# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Sec10 PF07393.11 AET37261.1 - 8.2e-41 140.2 1.9 8.7e-41 140.1 1.9 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 Homeobox_KN PF05920.11 AET37262.1 - 5.6e-08 32.6 0.5 1e-07 31.7 0.5 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 AET37262.1 - 2.5e-06 27.2 0.4 8.1e-06 25.6 0.3 1.9 2 0 0 2 2 2 1 Homeodomain Homez PF11569.8 AET37262.1 - 0.00063 19.2 0.0 0.0015 18.0 0.0 1.6 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez MATalpha_HMGbox PF04769.12 AET37263.1 - 8.4e-19 67.7 1.1 1.3e-18 67.1 1.1 1.3 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box SUI1 PF01253.22 AET37264.1 - 2.8e-26 91.8 0.1 3.6e-26 91.5 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2575 PF10837.8 AET37264.1 - 0.15 12.3 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) PALP PF00291.25 AET37265.1 - 3.7e-56 190.7 0.0 4.2e-56 190.5 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CoA_binding_2 PF13380.6 AET37265.1 - 0.086 13.3 0.0 0.67 10.5 0.0 2.2 2 0 0 2 2 2 0 CoA binding domain Vac17 PF17321.2 AET37266.1 - 1.6e-17 64.1 4.9 6.7e-17 62.1 4.9 2.0 1 1 0 1 1 1 1 Vacuole-related protein 17 MRC1 PF09444.10 AET37267.1 - 4.1e-36 124.7 4.7 4.1e-36 124.7 4.7 5.6 4 2 2 6 6 6 2 MRC1-like domain KH_8 PF17903.1 AET37268.1 - 1.4e-32 111.6 0.0 4.3e-32 110.0 0.0 1.9 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 AET37268.1 - 0.037 13.8 0.0 0.098 12.5 0.0 1.7 1 0 0 1 1 1 0 KH domain DUF543 PF04418.12 AET37269.1 - 3.3e-31 107.1 0.4 3.8e-31 106.9 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Peptidase_M3 PF01432.20 AET37270.1 - 9.3e-148 493.3 0.2 1.2e-147 492.9 0.2 1.1 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.6 AET37270.1 - 0.28 10.8 0.4 0.46 10.1 0.4 1.3 1 0 0 1 1 1 0 Peptidase M50B-like HisKA PF00512.25 AET37271.1 - 0.066 13.2 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain 2OG-FeII_Oxy_2 PF13532.6 AET37272.1 - 1.1e-20 74.6 0.1 1.5e-20 74.2 0.1 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF2225 PF09986.9 AET37272.1 - 0.021 14.5 0.4 0.034 13.8 0.4 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) 2OG-FeII_Oxy_3 PF13640.6 AET37272.1 - 0.06 14.2 0.4 0.51 11.3 0.0 2.7 2 2 1 3 3 3 0 2OG-Fe(II) oxygenase superfamily Zn_ribbon_recom PF13408.6 AET37272.1 - 0.3 11.6 4.0 0.85 10.2 4.0 1.7 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain SEO_C PF14577.6 AET37273.1 - 0.016 14.7 0.4 0.028 13.8 0.4 1.3 1 0 0 1 1 1 0 Sieve element occlusion C-terminus Tuberculin PF12198.8 AET37273.1 - 0.036 14.2 0.1 0.11 12.6 0.1 1.8 1 0 0 1 1 1 0 Theoretical tuberculin protein Voltage_CLC PF00654.20 AET37274.1 - 8.8e-80 268.6 17.5 8.8e-80 268.6 17.5 1.4 2 0 0 2 2 2 1 Voltage gated chloride channel Glyco_transf_56 PF07429.11 AET37275.1 - 0.014 14.5 0.0 1.5 7.8 0.0 2.4 2 0 0 2 2 2 0 4-alpha-L-fucosyltransferase glycosyl transferase group 56 MT-A70 PF05063.14 AET37276.1 - 7e-13 48.9 0.0 1e-12 48.3 0.0 1.2 1 0 0 1 1 1 1 MT-A70 CMAS PF02353.20 AET37277.1 - 1.2e-62 211.8 0.2 1.4e-62 211.5 0.2 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 AET37277.1 - 4.5e-11 43.3 0.0 1.1e-10 42.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AET37277.1 - 5.5e-10 39.3 0.0 9.3e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AET37277.1 - 1.5e-09 38.4 0.0 3.3e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AET37277.1 - 2.8e-07 31.2 0.0 5.4e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AET37277.1 - 0.0017 18.1 0.0 0.0038 17.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 AET37277.1 - 0.0069 16.5 0.1 0.015 15.4 0.0 1.6 2 0 0 2 2 2 1 FtsJ-like methyltransferase DOT1 PF08123.13 AET37277.1 - 0.045 13.3 0.0 0.093 12.2 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 MTS PF05175.14 AET37277.1 - 0.055 13.0 0.0 0.085 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 AET37277.1 - 0.12 12.1 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 AET37278.1 - 2.7e-54 183.9 0.1 5.7e-54 182.9 0.1 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase Spb1_C PF07780.12 AET37278.1 - 5.6e-53 179.7 10.7 5.6e-53 179.7 10.7 3.1 3 0 0 3 3 3 1 Spb1 C-terminal domain DUF3381 PF11861.8 AET37278.1 - 7.4e-46 156.0 17.3 7.4e-46 156.0 17.3 3.9 3 2 0 3 3 3 1 Domain of unknown function (DUF3381) SPATIAL PF15256.6 AET37278.1 - 0.34 11.2 4.9 0.24 11.7 1.2 2.4 2 0 0 2 2 2 0 SPATIAL EMP24_GP25L PF01105.24 AET37278.1 - 5.2 7.0 6.9 0.49 10.3 1.1 2.2 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD PIG-X PF08320.12 AET37279.1 - 1.5e-32 113.2 0.1 2.8e-32 112.4 0.1 1.4 1 0 0 1 1 1 1 PIG-X / PBN1 Toxin_4 PF00706.17 AET37280.1 - 0.13 12.7 0.1 0.25 11.8 0.1 1.5 1 0 0 1 1 1 0 Anenome neurotoxin MMU163 PF17119.5 AET37280.1 - 0.88 8.7 8.5 1.4 8.0 8.5 1.4 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Presenilin PF01080.17 AET37280.1 - 1.2 7.8 13.8 1.7 7.3 13.8 1.3 1 0 0 1 1 1 0 Presenilin NST1 PF13945.6 AET37280.1 - 1.5 8.9 39.2 2.4 8.2 39.2 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator Tim54 PF11711.8 AET37280.1 - 2.7 6.7 8.4 3.6 6.3 8.4 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Pex14_N PF04695.13 AET37280.1 - 2.7 8.6 5.6 5.9 7.5 5.6 1.7 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CPSF100_C PF13299.6 AET37280.1 - 2.8 8.1 9.7 5.2 7.2 9.7 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal NPR3 PF03666.13 AET37280.1 - 8.2 5.1 17.6 11 4.7 17.6 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Folliculin PF11704.8 AET37280.1 - 8.2 6.3 10.1 18 5.2 10.1 1.6 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport UCR_14kD PF02271.16 AET37281.1 - 2.9e-37 126.6 0.1 3.4e-37 126.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit ATP_transf PF09830.9 AET37282.1 - 1.7e-18 66.5 0.1 3.5e-18 65.5 0.1 1.6 1 0 0 1 1 1 1 ATP adenylyltransferase HIT PF01230.23 AET37282.1 - 9.4e-05 23.1 0.0 0.00031 21.4 0.0 1.9 1 0 0 1 1 1 1 HIT domain DUF4931 PF16285.5 AET37282.1 - 0.00016 21.1 0.0 0.00023 20.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4931) DUF4922 PF16269.5 AET37282.1 - 0.0098 15.7 0.0 0.023 14.5 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4922) Hormone_1 PF00103.20 AET37282.1 - 0.024 14.4 0.1 7 6.3 0.0 2.4 2 0 0 2 2 2 0 Somatotropin hormone family Fumble PF03630.14 AET37283.1 - 2.9e-109 365.2 3.6 6.2e-108 360.9 3.6 2.0 1 1 0 1 1 1 1 Fumble RPAP1_C PF08620.10 AET37284.1 - 6.2e-28 96.7 0.1 1.2e-27 95.8 0.1 1.5 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 AET37284.1 - 1.6e-16 59.7 1.4 2.2e-16 59.3 0.1 1.9 2 0 0 2 2 2 1 RPAP1-like, N-terminal LIN52 PF10044.9 AET37284.1 - 0.18 12.5 2.0 2.4 8.9 0.1 2.5 2 0 0 2 2 2 0 Retinal tissue protein Asp_Glu_race PF01177.22 AET37285.1 - 4.8e-05 23.3 0.0 0.03 14.2 0.0 2.4 3 0 0 3 3 3 2 Asp/Glu/Hydantoin racemase Fucose_iso_N1 PF07881.12 AET37286.1 - 0.048 13.5 1.3 0.056 13.3 1.3 1.1 1 0 0 1 1 1 0 L-fucose isomerase, first N-terminal domain Enamelin PF15362.6 AET37286.1 - 1.4 7.1 5.6 1.5 7.0 5.6 1.0 1 0 0 1 1 1 0 Enamelin ArfGap PF01412.18 AET37287.1 - 3.1e-29 101.4 0.7 1.1e-28 99.7 0.3 2.1 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.29 AET37287.1 - 2.9e-11 43.8 0.9 8.6e-10 39.1 0.3 2.9 2 0 0 2 2 2 1 PH domain BAR_3 PF16746.5 AET37287.1 - 0.00045 20.0 5.6 0.00074 19.3 4.7 1.7 2 0 0 2 2 2 1 BAR domain of APPL family PH_9 PF15410.6 AET37287.1 - 0.013 15.8 0.1 0.047 14.0 0.1 1.9 1 1 0 1 1 1 0 Pleckstrin homology domain DUF3730 PF12530.8 AET37287.1 - 0.027 14.0 0.4 0.027 14.0 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3730) PH_11 PF15413.6 AET37287.1 - 0.33 11.4 7.8 0.26 11.7 2.8 3.2 3 1 0 3 3 3 0 Pleckstrin homology domain Pkinase PF00069.25 AET37288.1 - 9.9e-70 234.9 0.0 1.3e-69 234.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET37288.1 - 9e-48 162.8 0.0 1.3e-47 162.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET37288.1 - 0.00049 19.5 0.0 0.0081 15.5 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 AET37288.1 - 0.013 14.3 0.0 0.022 13.5 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Recep_L_domain PF01030.24 AET37289.1 - 7.6e-09 35.7 8.8 0.0057 16.8 0.4 4.4 1 1 4 5 5 5 4 Receptor L domain LRR_4 PF12799.7 AET37289.1 - 0.17 12.4 13.1 4.4 7.8 0.1 5.5 3 1 0 4 4 4 0 Leucine Rich repeats (2 copies) Zn_clus PF00172.18 AET37290.1 - 7.2e-05 22.8 6.0 0.00016 21.7 6.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CTP_transf_like PF01467.26 AET37291.1 - 4.5e-07 30.1 0.2 1.3e-06 28.6 0.2 1.8 1 1 0 1 1 1 1 Cytidylyltransferase-like HIGH_NTase1 PF05636.11 AET37291.1 - 0.0045 16.3 0.9 0.28 10.3 0.1 2.1 2 0 0 2 2 2 2 HIGH Nucleotidyl Transferase ATP-sulfurylase PF01747.17 AET37291.1 - 0.035 13.6 0.3 0.29 10.6 0.3 2.0 1 1 0 1 1 1 0 ATP-sulfurylase Phage_integr_3 PF16795.5 AET37291.1 - 0.1 12.5 0.1 2 8.3 0.1 2.4 1 1 1 2 2 2 0 Archaeal phage integrase EMC1_C PF07774.13 AET37292.1 - 3.9e-63 213.0 0.6 3.9e-63 213.0 0.6 1.7 2 0 0 2 2 2 1 ER membrane protein complex subunit 1, C-terminal PQQ PF01011.21 AET37292.1 - 0.00025 20.8 0.0 0.0042 17.0 0.0 2.7 3 0 0 3 3 3 1 PQQ enzyme repeat PQQ_2 PF13360.6 AET37292.1 - 0.071 12.7 0.0 0.39 10.3 0.0 2.0 2 1 0 2 2 2 0 PQQ-like domain TGase_elicitor PF16683.5 AET37292.1 - 0.1 11.3 0.7 0.21 10.3 0.7 1.4 1 0 0 1 1 1 0 Transglutaminase elicitor Mgr1 PF08602.10 AET37293.1 - 1.9e-156 520.8 0.0 2.2e-156 520.6 0.0 1.0 1 0 0 1 1 1 1 Mgr1-like, i-AAA protease complex subunit DUF2922 PF11148.8 AET37293.1 - 0.045 13.5 0.1 0.11 12.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2922) Thioredoxin PF00085.20 AET37294.1 - 3.1e-53 178.1 0.5 2.7e-25 88.3 0.0 3.7 4 0 0 4 4 4 3 Thioredoxin Thioredoxin_6 PF13848.6 AET37294.1 - 1.2e-21 77.5 2.2 1.6e-17 64.0 0.3 3.6 3 1 1 4 4 4 3 Thioredoxin-like domain OST3_OST6 PF04756.13 AET37294.1 - 1.9e-10 40.6 0.1 1.7e-05 24.3 0.0 2.7 2 1 1 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 AET37294.1 - 1.3e-08 35.2 0.3 0.002 18.6 0.0 3.2 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 AET37294.1 - 1.7e-07 31.3 0.0 0.024 14.8 0.0 2.8 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 AET37294.1 - 5.2e-05 23.2 0.2 0.088 12.7 0.0 3.2 4 0 0 4 4 4 2 AhpC/TSA family Thioredoxin_8 PF13905.6 AET37294.1 - 0.0022 18.3 0.0 0.44 10.9 0.0 3.2 2 2 1 3 3 3 1 Thioredoxin-like Redoxin PF08534.10 AET37294.1 - 0.023 14.4 0.0 0.55 9.9 0.0 2.4 2 0 0 2 2 2 0 Redoxin Thioredoxin_9 PF14595.6 AET37294.1 - 0.04 13.7 0.0 7.3 6.4 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin GRASP55_65 PF04495.14 AET37295.1 - 6.5e-36 123.7 0.0 1.8e-34 119.0 0.0 2.1 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain Hexokinase_2 PF03727.16 AET37296.1 - 3.8e-77 259.0 0.0 5.1e-77 258.6 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 AET37296.1 - 1.3e-68 230.8 0.0 2.3e-68 230.0 0.0 1.4 1 0 0 1 1 1 1 Hexokinase T3SS_needle_E PF08988.10 AET37296.1 - 0.0096 16.0 0.4 0.02 15.0 0.4 1.5 1 0 0 1 1 1 1 Type III secretion system, cytoplasmic E component of needle RecG_N PF17190.4 AET37296.1 - 0.5 11.1 3.1 0.44 11.3 0.3 2.4 3 0 0 3 3 3 0 RecG N-terminal helical domain WD40 PF00400.32 AET37297.1 - 5.3e-16 58.7 7.8 0.0024 18.7 0.0 6.9 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET37297.1 - 5.2e-08 33.1 0.1 0.02 15.2 0.0 4.7 3 2 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_N PF14781.6 AET37297.1 - 0.025 14.5 1.3 7.5 6.5 0.1 3.7 2 2 0 2 2 2 0 Ciliary BBSome complex subunit 2, N-terminal Lactonase PF10282.9 AET37297.1 - 0.099 11.9 0.6 0.2 10.9 0.1 1.7 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller ATG22 PF11700.8 AET37298.1 - 1.1e-153 512.3 29.2 1.3e-153 512.1 29.2 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 AET37298.1 - 3.2e-08 32.9 17.0 3.2e-08 32.9 17.0 2.9 1 1 2 3 3 3 3 Major Facilitator Superfamily La PF05383.17 AET37299.1 - 4.4e-17 61.9 0.0 9.2e-17 60.9 0.0 1.6 1 0 0 1 1 1 1 La domain HSBP1 PF06825.12 AET37300.1 - 0.051 13.4 0.1 0.14 12.1 0.1 1.7 1 0 0 1 1 1 0 Heat shock factor binding protein 1 Apolipoprotein PF01442.18 AET37300.1 - 0.1 12.4 0.6 0.36 10.7 0.6 1.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Flocculin_t3 PF13928.6 AET37301.1 - 1.2e-17 64.2 52.0 1.8e-07 31.5 5.3 4.3 4 1 0 4 4 4 3 Flocculin type 3 repeat DUF5501 PF17605.2 AET37301.1 - 0.21 12.0 7.9 25 5.4 0.2 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5501) Glutaredoxin PF00462.24 AET37302.1 - 6.2e-16 58.4 0.0 9.3e-16 57.8 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.6 AET37302.1 - 0.015 15.7 0.0 0.023 15.2 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain GST_N_3 PF13417.6 AET37302.1 - 0.033 14.6 0.0 0.059 13.8 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GAT PF03127.14 AET37303.1 - 8e-05 22.9 0.5 0.00025 21.3 0.1 2.2 2 0 0 2 2 2 1 GAT domain VHS PF00790.19 AET37303.1 - 0.061 13.2 0.1 0.22 11.4 0.1 1.9 2 0 0 2 2 2 0 VHS domain DUF2381 PF09544.10 AET37303.1 - 0.099 12.2 0.4 0.16 11.5 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2381) SelR PF01641.18 AET37304.1 - 2.3e-47 160.1 0.1 2.8e-47 159.7 0.1 1.1 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.14 AET37304.1 - 0.0028 17.8 1.3 0.0043 17.2 1.3 1.4 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly NdhS PF11623.8 AET37304.1 - 0.088 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H dehydrogenase subunit S DUF3128 PF11326.8 AET37305.1 - 4.2e-25 87.9 1.2 4.6e-25 87.8 1.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) Peptidase_M15_3 PF08291.11 AET37305.1 - 0.033 14.3 0.0 0.041 14.0 0.0 1.3 1 1 0 1 1 1 0 Peptidase M15 RA PF00788.23 AET37306.1 - 2.1e-15 57.1 0.1 4.4e-15 56.1 0.1 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_Ste50p PF09235.10 AET37306.1 - 6.4e-14 51.9 1.7 7.4e-10 38.9 0.0 2.5 2 0 0 2 2 2 2 Ste50p, sterile alpha motif REPA_OB_2 PF16900.5 AET37306.1 - 0.056 13.4 0.2 0.21 11.6 0.1 2.0 2 0 0 2 2 2 0 Replication protein A OB domain SAM_2 PF07647.17 AET37306.1 - 0.085 13.0 0.7 4.4 7.5 0.0 2.8 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) RRM_Rrp7 PF17799.1 AET37307.1 - 5.1e-37 127.2 3.8 5.1e-37 127.2 3.8 1.6 2 0 0 2 2 2 1 Rrp7 RRM-like N-terminal domain RRP7 PF12923.7 AET37307.1 - 1e-25 90.2 10.1 2e-25 89.2 10.1 1.5 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Adenyl_cycl_N PF12633.7 AET37307.1 - 0.0086 16.0 0.1 0.024 14.5 0.1 1.7 1 0 0 1 1 1 1 Adenylate cyclase NT domain Complex1_LYR_2 PF13233.6 AET37308.1 - 6.8e-18 65.2 1.1 9.4e-18 64.8 0.2 1.8 2 1 0 2 2 2 1 Complex1_LYR-like Complex1_LYR PF05347.15 AET37308.1 - 3.2e-09 36.7 0.1 8.2e-09 35.4 0.0 1.8 2 0 0 2 2 2 1 Complex 1 protein (LYR family) DUF4028 PF13220.6 AET37308.1 - 0.037 13.8 0.0 0.085 12.6 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4028) Histidinol_dh PF00815.20 AET37309.1 - 2.5e-160 534.0 0.8 3.7e-160 533.4 0.8 1.3 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 AET37309.1 - 1.7e-25 88.6 0.0 3.5e-25 87.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 AET37309.1 - 1.6e-13 50.9 0.2 3.7e-13 49.7 0.2 1.6 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase MazG PF03819.17 AET37309.1 - 0.08 13.1 0.7 0.17 12.1 0.7 1.6 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain CAP_GLY PF01302.25 AET37310.1 - 4.3e-14 52.3 1.9 4.7e-14 52.2 0.3 1.9 2 0 0 2 2 2 1 CAP-Gly domain CLIP1_ZNF PF16641.5 AET37310.1 - 0.00018 21.3 0.8 0.00028 20.7 0.8 1.3 1 0 0 1 1 1 1 CLIP1 zinc knuckle Tropomyosin_1 PF12718.7 AET37310.1 - 0.002 18.3 13.5 0.002 18.3 13.5 2.5 1 1 1 2 2 1 1 Tropomyosin like GAS PF13851.6 AET37310.1 - 0.017 14.5 37.5 0.036 13.4 26.9 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding CCDC144C PF14915.6 AET37310.1 - 0.019 14.1 34.1 0.046 12.8 22.5 2.6 1 1 1 2 2 2 0 CCDC144C protein coiled-coil region MinE PF03776.14 AET37310.1 - 0.039 14.0 3.6 0.12 12.4 3.6 1.9 1 0 0 1 1 1 0 Septum formation topological specificity factor MinE HAUS-augmin3 PF14932.6 AET37310.1 - 0.053 13.1 26.3 0.43 10.1 8.8 2.3 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 UPF0242 PF06785.11 AET37310.1 - 0.1 12.7 44.4 0.085 13.0 7.4 3.2 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus zf-C2H2_aberr PF17017.5 AET37310.1 - 0.17 12.0 2.9 0.38 10.9 2.9 1.6 1 0 0 1 1 1 0 Aberrant zinc-finger MscS_porin PF12795.7 AET37310.1 - 0.18 11.3 33.8 0.11 12.0 29.4 2.2 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain DUF3584 PF12128.8 AET37310.1 - 1.1 6.6 33.9 0.76 7.2 23.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) HALZ PF02183.18 AET37310.1 - 5.2 7.4 20.3 0.067 13.4 3.3 4.4 4 0 0 4 4 4 0 Homeobox associated leucine zipper TPR_MLP1_2 PF07926.12 AET37310.1 - 5.2 7.1 33.4 13 5.9 11.3 4.2 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein Allexi_40kDa PF05549.11 AET37310.1 - 5.2 6.5 14.5 0.34 10.4 4.6 2.4 1 1 1 2 2 2 0 Allexivirus 40kDa protein PspA_IM30 PF04012.12 AET37310.1 - 6.7 6.2 26.7 2.6 7.6 19.8 3.0 1 1 1 2 2 2 0 PspA/IM30 family Med8 PF10232.9 AET37311.1 - 0.11 12.1 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 CAP PF00188.26 AET37312.1 - 9e-23 81.5 1.6 1.4e-22 80.9 1.6 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family SH3_9 PF14604.6 AET37313.1 - 4.7e-06 26.4 0.0 5.9e-05 22.9 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 AET37313.1 - 0.017 14.7 0.0 0.038 13.6 0.0 1.6 1 0 0 1 1 1 0 SH3 domain DUF1201 PF06716.11 AET37313.1 - 0.16 12.0 0.0 0.35 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1201) AA_permease PF00324.21 AET37314.1 - 8.3e-130 433.6 37.2 9.4e-130 433.4 37.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AET37314.1 - 1.3e-31 109.9 37.4 1.6e-31 109.6 37.4 1.1 1 0 0 1 1 1 1 Amino acid permease Pet100 PF09803.9 AET37314.1 - 0.57 10.7 1.8 2 9.0 0.1 2.3 2 0 0 2 2 2 0 Pet100 Rad60-SLD PF11976.8 AET37315.1 - 1.5e-18 66.4 0.0 2e-18 66.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 AET37315.1 - 2e-11 43.5 0.0 2.4e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Pkinase PF00069.25 AET37316.1 - 5.3e-72 242.3 0.0 2.2e-71 240.3 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Fungal_KA1 PF16797.5 AET37316.1 - 2.5e-35 120.7 1.8 6e-35 119.5 1.8 1.7 1 0 0 1 1 1 1 Fungal kinase associated-1 domain Pkinase_Tyr PF07714.17 AET37316.1 - 8.1e-34 117.1 0.0 2e-33 115.8 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET37316.1 - 5e-07 29.3 0.0 4.5e-06 26.2 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Cu-oxidase_2 PF07731.14 AET37317.1 - 5e-34 117.0 3.2 1.6e-27 95.9 1.5 3.5 3 0 0 3 3 3 3 Multicopper oxidase Cu-oxidase_3 PF07732.15 AET37317.1 - 3.3e-28 98.1 2.7 2.8e-27 95.1 0.6 3.0 3 1 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 AET37317.1 - 2.3e-24 86.3 1.1 2.6e-22 79.6 0.0 3.1 3 0 0 3 3 3 2 Multicopper oxidase PSP1 PF04468.12 AET37318.1 - 2e-43 146.5 0.0 2e-43 146.5 0.0 2.7 2 1 0 2 2 1 1 PSP1 C-terminal conserved region DDHD PF02862.17 AET37318.1 - 0.00062 20.0 5.2 0.00062 20.0 5.2 2.8 3 0 0 3 3 3 1 DDHD domain EPL1 PF10513.9 AET37318.1 - 0.0015 19.0 8.8 0.0015 19.0 8.8 2.7 3 0 0 3 3 3 1 Enhancer of polycomb-like Spem1 PF15670.5 AET37318.1 - 0.0045 16.6 13.4 0.01 15.4 13.4 1.6 1 0 0 1 1 1 1 Spermatid maturation protein 1 eIF-3_zeta PF05091.12 AET37318.1 - 0.05 12.6 19.3 0.086 11.8 19.3 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PAT1 PF09770.9 AET37318.1 - 0.16 10.2 31.9 0.25 9.6 31.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SpoIIP PF07454.11 AET37318.1 - 0.24 10.8 18.2 0.5 9.8 18.2 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Tim54 PF11711.8 AET37318.1 - 1 8.1 18.3 1.8 7.2 18.3 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RR_TM4-6 PF06459.12 AET37318.1 - 2.5 7.9 19.0 5.7 6.7 19.0 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Eapp_C PF10238.9 AET37318.1 - 3.1 7.9 18.9 4.4 7.4 16.8 2.2 2 0 0 2 2 2 0 E2F-associated phosphoprotein PepSY_TM PF03929.16 AET37318.1 - 3.3 7.3 7.1 6.3 6.4 7.1 1.4 1 0 0 1 1 1 0 PepSY-associated TM region SID-1_RNA_chan PF13965.6 AET37318.1 - 3.7 5.8 6.1 5.7 5.2 6.1 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF3408 PF11888.8 AET37318.1 - 5.4 7.2 17.8 18 5.5 17.8 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) CobT PF06213.12 AET37318.1 - 5.8 6.2 28.1 1.2 8.4 23.4 2.0 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Band_3_cyto PF07565.13 AET37318.1 - 7.9 6.2 18.8 23 4.7 18.8 1.7 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2828 PF11443.8 AET37318.1 - 7.9 4.4 16.8 13 3.7 16.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4407 PF14362.6 AET37318.1 - 9 5.6 17.6 16 4.7 17.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4638 PF15472.6 AET37318.1 - 9.7 5.8 14.8 19 4.9 14.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) PBP PF01161.20 AET37319.1 - 2e-16 60.5 0.0 2.7e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Cupin_3 PF05899.12 AET37319.1 - 0.00019 21.0 0.0 0.00041 20.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF861) MAF_flag10 PF01973.18 AET37319.1 - 0.22 11.2 0.0 0.3 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF115 PAP2 PF01569.21 AET37320.1 - 3.6e-23 81.9 3.2 3.6e-23 81.9 3.2 1.7 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 AET37320.1 - 5.3e-08 32.8 1.4 1.2e-07 31.6 1.1 1.8 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 AET37320.1 - 0.00034 21.1 1.0 0.0025 18.3 0.7 2.4 2 0 0 2 2 2 1 PAP2 superfamily C-terminal Androgen_recep PF02166.16 AET37320.1 - 2.7 6.8 6.5 4.1 6.1 6.5 1.1 1 0 0 1 1 1 0 Androgen receptor S-AdoMet_synt_C PF02773.16 AET37321.1 - 1.1e-63 213.4 0.0 1.9e-63 212.6 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_N PF00438.20 AET37321.1 - 2.5e-45 153.2 0.1 4.9e-45 152.3 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_M PF02772.16 AET37321.1 - 7.8e-45 152.0 0.0 1.8e-44 150.9 0.0 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain AdoMet_Synthase PF01941.19 AET37321.1 - 0.058 12.2 0.1 0.13 11.0 0.1 1.5 1 0 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) Vta1 PF04652.16 AET37322.1 - 1.1e-30 106.5 0.6 3.1e-30 105.1 0.1 1.8 2 0 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 AET37322.1 - 1.6e-15 56.5 3.1 1.6e-15 56.5 3.1 1.8 2 0 0 2 2 2 1 Vta1 C-terminal domain DUF1308 PF07000.11 AET37322.1 - 0.079 12.9 0.0 11 6.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1308) Swi6_N PF18530.1 AET37323.1 - 1.1e-13 51.3 2.6 2.1e-13 50.4 0.2 2.7 2 0 0 2 2 2 1 Swi6 N-terminal domain Ank_3 PF13606.6 AET37323.1 - 3.5e-10 39.2 0.7 0.0007 19.9 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 AET37323.1 - 1.1e-09 38.3 0.1 2.6e-05 24.4 0.1 3.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 AET37323.1 - 2.4e-09 37.6 0.1 0.0022 18.5 0.1 3.0 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 AET37323.1 - 3.6e-08 33.5 4.0 0.0019 18.5 0.1 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 AET37323.1 - 2.3e-07 31.2 0.3 0.024 15.2 0.0 3.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Phage_GPO PF05929.11 AET37323.1 - 0.00046 19.9 0.4 0.00046 19.9 0.4 1.8 3 0 0 3 3 2 1 Phage capsid scaffolding protein (GPO) serine peptidase Bac_RepA_C PF18008.1 AET37323.1 - 0.037 14.4 1.8 0.08 13.3 0.1 2.4 3 0 0 3 3 3 0 Replication initiator protein A C-terminal domain Atg14 PF10186.9 AET37323.1 - 0.065 12.3 8.1 0.014 14.5 3.7 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 OmpH PF03938.14 AET37323.1 - 0.11 12.8 10.0 0.15 12.4 4.2 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) KfrA_N PF11740.8 AET37323.1 - 0.14 12.8 3.6 0.23 12.1 0.8 2.7 3 0 0 3 3 2 0 Plasmid replication region DNA-binding N-term DUF4140 PF13600.6 AET37323.1 - 0.22 12.0 3.6 2.8 8.4 0.6 2.6 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF3552 PF12072.8 AET37323.1 - 0.52 9.7 12.1 0.54 9.7 6.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) DUF4615 PF15393.6 AET37323.1 - 6.1 7.4 10.7 0.39 11.3 0.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4615) FHA PF00498.26 AET37324.1 - 6.9e-07 29.5 1.2 9.9e-06 25.8 0.0 3.4 4 0 0 4 4 4 1 FHA domain Yop-YscD_cpl PF16697.5 AET37324.1 - 0.091 13.1 0.0 1.1 9.7 0.0 2.6 1 1 1 2 2 2 0 Inner membrane component of T3SS, cytoplasmic domain Ribosomal_L37e PF01907.19 AET37325.1 - 9.4e-29 99.4 11.2 1.5e-28 98.7 11.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 AET37325.1 - 0.0046 17.0 1.3 0.0068 16.4 1.3 1.2 1 0 0 1 1 1 1 Double zinc ribbon SelR PF01641.18 AET37325.1 - 0.013 15.5 0.4 0.015 15.3 0.4 1.2 1 0 0 1 1 1 0 SelR domain DUF1258 PF06869.12 AET37325.1 - 0.017 14.6 0.5 0.017 14.6 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) Zn-ribbon_8 PF09723.10 AET37325.1 - 0.19 11.9 2.0 0.34 11.0 2.0 1.5 1 1 0 1 1 1 0 Zinc ribbon domain HypA PF01155.19 AET37325.1 - 0.19 11.7 1.0 0.27 11.3 1.0 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.6 AET37325.1 - 0.24 10.9 3.2 0.58 9.7 3.2 1.7 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 AET37325.1 - 0.38 10.5 4.7 6.6 6.6 0.7 2.2 2 0 0 2 2 2 0 zinc-ribbon domain LCD1 PF09798.9 AET37326.1 - 2.7e-186 620.7 26.4 3.1e-186 620.6 26.4 1.0 1 0 0 1 1 1 1 DNA damage checkpoint protein EMG1 PF03587.14 AET37327.1 - 3.2e-77 258.6 0.0 3.8e-77 258.4 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase RP854 PF17460.2 AET37327.1 - 0.0054 16.5 0.0 0.0078 16.0 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein RP854 LapA_dom PF06305.11 AET37328.1 - 0.068 13.0 1.1 0.51 10.2 0.1 2.7 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DUF4834 PF16118.5 AET37328.1 - 0.14 13.1 0.0 25 5.9 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) SCIMP PF15050.6 AET37328.1 - 0.15 12.5 0.2 5.2 7.5 0.1 2.8 2 0 0 2 2 2 0 SCIMP protein DUF948 PF06103.11 AET37328.1 - 0.15 12.3 10.8 0.43 10.9 0.2 4.4 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) COX2_TM PF02790.15 AET37328.1 - 1.6 9.0 5.7 3.4 7.9 0.0 3.5 4 0 0 4 4 4 0 Cytochrome C oxidase subunit II, transmembrane domain SecE PF00584.20 AET37328.1 - 2.2 8.2 10.2 0.041 13.8 1.7 2.5 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex PH PF00169.29 AET37329.1 - 9.1e-06 26.1 0.1 0.0019 18.7 0.0 2.8 2 0 0 2 2 2 2 PH domain ABC_membrane PF00664.23 AET37330.1 - 7.6e-61 206.2 1.7 9.6e-61 205.8 1.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 AET37330.1 - 9.3e-30 103.9 0.0 2.1e-29 102.8 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 AET37330.1 - 1.4e-07 31.1 0.0 1.2e-06 28.1 0.0 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 AET37330.1 - 0.0038 16.1 0.1 0.0065 15.3 0.1 1.3 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_16 PF13191.6 AET37330.1 - 0.011 16.1 0.1 0.059 13.8 0.1 2.2 2 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 AET37330.1 - 0.02 15.1 0.1 0.25 11.6 0.1 2.5 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.17 AET37330.1 - 0.025 14.7 0.1 0.34 11.0 0.0 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_5 PF07728.14 AET37330.1 - 0.053 13.5 0.0 0.31 11.0 0.0 2.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 AET37330.1 - 0.093 13.3 0.0 0.59 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain 6PF2K PF01591.18 AET37330.1 - 0.11 11.8 0.0 0.27 10.5 0.0 1.6 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_29 PF13555.6 AET37330.1 - 0.12 12.2 0.1 0.37 10.6 0.1 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain DEAD PF00270.29 AET37330.1 - 0.13 12.1 0.0 22 4.7 0.0 2.5 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA PF00004.29 AET37330.1 - 0.13 12.7 0.5 1.9 8.9 0.3 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Abhydrolase_1 PF00561.20 AET37331.1 - 2.9e-58 197.5 0.1 4.3e-58 197.0 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AET37331.1 - 2.9e-06 28.0 0.3 4.5e-06 27.4 0.3 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AET37331.1 - 0.046 13.0 0.0 0.15 11.3 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 GRAM PF02893.20 AET37332.1 - 1.2e-31 108.9 1.4 3.7e-23 81.6 0.1 2.7 2 0 0 2 2 2 2 GRAM domain Glyco_transf_28 PF03033.20 AET37332.1 - 2.3e-28 98.9 0.0 5.1e-28 97.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain PH PF00169.29 AET37332.1 - 2.4e-07 31.2 0.3 2.5e-06 27.9 0.2 2.7 2 0 0 2 2 2 1 PH domain UDPGT PF00201.18 AET37332.1 - 0.00018 20.5 0.4 0.00048 19.1 0.4 1.6 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_11 PF15413.6 AET37332.1 - 0.0038 17.6 2.0 0.029 14.8 1.0 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain Exo_endo_phos PF03372.23 AET37333.1 - 1.3e-13 51.0 0.1 2e-13 50.4 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF21 PF01595.20 AET37333.1 - 0.5 10.0 3.2 0.47 10.1 2.1 1.4 1 1 0 1 1 1 0 Cyclin M transmembrane N-terminal domain Spindle_Spc25 PF08234.12 AET37334.1 - 2.6e-19 69.2 0.7 4.3e-19 68.5 0.1 1.7 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 GAS PF13851.6 AET37334.1 - 6.4e-05 22.4 21.0 0.00011 21.6 21.0 1.4 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Myosin_tail_1 PF01576.19 AET37334.1 - 0.0026 15.7 18.1 0.0034 15.3 18.1 1.1 1 0 0 1 1 1 1 Myosin tail Atg14 PF10186.9 AET37334.1 - 0.0036 16.4 14.9 0.0052 15.9 14.9 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 APG6_N PF17675.1 AET37334.1 - 0.0076 16.8 19.8 0.016 15.7 19.8 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region Spc7 PF08317.11 AET37334.1 - 0.021 13.7 14.2 0.032 13.1 14.2 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein UPF0184 PF03670.13 AET37334.1 - 0.025 14.9 6.2 0.11 12.9 3.9 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0184) KASH_CCD PF14662.6 AET37334.1 - 0.046 13.6 20.8 0.022 14.6 18.4 1.6 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH V_ATPase_I PF01496.19 AET37334.1 - 0.15 10.0 9.7 0.16 9.8 9.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FapA PF03961.13 AET37334.1 - 0.34 9.5 12.1 0.51 8.9 12.1 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A Exonuc_VII_L PF02601.15 AET37334.1 - 0.42 10.1 8.5 0.47 10.0 8.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit ERM PF00769.19 AET37334.1 - 0.47 10.2 21.5 0.21 11.4 18.2 1.5 1 1 0 1 1 1 0 Ezrin/radixin/moesin family YabA PF06156.13 AET37334.1 - 0.56 10.9 15.6 0.23 12.1 11.2 2.3 1 1 2 3 3 3 0 Initiation control protein YabA ADIP PF11559.8 AET37334.1 - 0.64 10.1 19.0 0.093 12.8 15.0 1.6 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.6 AET37334.1 - 0.8 9.0 10.2 1.2 8.4 10.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Jnk-SapK_ap_N PF09744.9 AET37334.1 - 4 7.7 23.3 2.3 8.4 21.4 1.6 2 0 0 2 2 1 0 JNK_SAPK-associated protein-1 DUF1664 PF07889.12 AET37334.1 - 4.2 7.4 10.2 1.1 9.3 6.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF3450 PF11932.8 AET37334.1 - 4.2 6.6 18.8 3.4 6.9 15.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) FAM76 PF16046.5 AET37334.1 - 5 6.4 12.2 6.7 6.0 12.2 1.2 1 0 0 1 1 1 0 FAM76 protein CHD5 PF04420.14 AET37334.1 - 5.6 6.8 11.3 10 6.0 11.3 1.3 1 0 0 1 1 1 0 CHD5-like protein AAA_11 PF13086.6 AET37334.1 - 6.1 6.6 11.2 9.6 5.9 11.2 1.4 1 0 0 1 1 1 0 AAA domain UPF0242 PF06785.11 AET37334.1 - 9.9 6.2 24.6 31 4.6 24.6 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Per1 PF04080.13 AET37335.1 - 1.4e-84 283.9 13.8 1.7e-84 283.6 13.8 1.0 1 0 0 1 1 1 1 Per1-like family HCO3_cotransp PF00955.21 AET37336.1 - 1.7e-75 254.8 11.5 7e-41 140.6 2.3 2.0 1 1 1 2 2 2 2 HCO3- transporter family DUF2615 PF11027.8 AET37337.1 - 0.11 12.6 0.0 14 5.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) Sad1_UNC PF07738.13 AET37338.1 - 3.5e-31 107.9 0.0 6.5e-31 107.1 0.0 1.5 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal PhaP_Bmeg PF09602.10 AET37338.1 - 0.031 14.2 4.1 0.12 12.3 0.6 2.8 2 1 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Cyclin_N PF00134.23 AET37339.1 - 3e-31 107.8 2.1 4.6e-31 107.2 1.2 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 AET37339.1 - 1.4e-06 28.4 0.2 3.5e-06 27.1 0.2 1.7 1 0 0 1 1 1 1 Cyclin, C-terminal domain TIMELESS PF04821.14 AET37340.1 - 2.3e-86 289.5 0.5 4.2e-86 288.6 0.0 1.7 2 0 0 2 2 2 1 Timeless protein DUF4775 PF16001.5 AET37340.1 - 1.8 7.9 7.5 0.12 11.7 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4775) FAM60A PF15396.6 AET37340.1 - 7 6.6 7.1 20 5.1 0.1 3.2 3 0 0 3 3 3 0 Protein Family FAM60A Aa_trans PF01490.18 AET37341.1 - 2.7e-84 283.3 31.1 3.1e-84 283.1 31.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF4199 PF13858.6 AET37341.1 - 0.0085 16.5 0.3 0.0085 16.5 0.3 4.7 4 1 1 5 5 5 2 Protein of unknown function (DUF4199) Sec2p PF06428.11 AET37342.1 - 2.1e-27 94.9 13.2 2.1e-27 94.9 13.2 3.3 2 1 0 2 2 2 1 GDP/GTP exchange factor Sec2p HMMR_N PF15905.5 AET37342.1 - 0.00063 19.3 27.3 0.00063 19.3 27.3 2.8 3 0 0 3 3 3 1 Hyaluronan mediated motility receptor N-terminal DUF745 PF05335.13 AET37342.1 - 1.8 8.3 20.5 1.1 8.9 1.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF5339 PF17274.2 AET37342.1 - 2.4 9.1 12.1 5.2 8.0 2.6 3.7 2 1 1 3 3 3 0 Family of unknown function (DUF5339) FH2 PF02181.23 AET37343.1 - 5.5e-87 292.3 10.7 5.5e-87 292.3 10.7 3.4 4 0 0 4 4 4 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 AET37343.1 - 5.3e-47 160.0 7.8 8.6e-46 156.0 0.1 3.6 3 0 0 3 3 3 2 Diaphanous FH3 Domain Drf_GBD PF06371.13 AET37343.1 - 5.5e-30 104.3 1.0 5.5e-30 104.3 1.0 3.7 4 0 0 4 4 4 1 Diaphanous GTPase-binding Domain TEX13 PF15186.6 AET37343.1 - 3.4 7.4 13.2 1.5 8.5 3.9 3.1 1 1 0 2 2 2 0 Testis-expressed sequence 13 protein family DUF2935 PF11155.8 AET37343.1 - 3.6 7.9 6.0 4.6 7.6 1.0 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) DUF148 PF02520.17 AET37343.1 - 4.4 7.5 9.6 0.91 9.7 3.1 3.3 3 0 0 3 3 3 0 Domain of unknown function DUF148 AA_permease PF00324.21 AET37344.1 - 2.1e-136 455.3 44.4 2.5e-136 455.1 44.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AET37344.1 - 2.5e-32 112.3 50.6 4e-32 111.6 50.5 1.4 1 1 0 1 1 1 1 Amino acid permease RhodobacterPufX PF11511.8 AET37344.1 - 1.9 8.2 9.3 0.23 11.1 0.3 3.2 3 0 0 3 3 3 0 Intrinsic membrane protein PufX AA_permease PF00324.21 AET37345.1 - 9.6e-135 449.9 46.7 1.1e-134 449.7 46.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AET37345.1 - 1.5e-37 129.4 51.0 2.1e-37 129.0 51.0 1.2 1 0 0 1 1 1 1 Amino acid permease RhodobacterPufX PF11511.8 AET37345.1 - 1.9 8.1 10.5 0.17 11.5 0.3 3.6 4 0 0 4 4 4 0 Intrinsic membrane protein PufX DUF3767 PF12597.8 AET37345.1 - 4.2 7.2 5.6 0.55 10.1 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3767) PI3_PI4_kinase PF00454.27 AET37346.1 - 4.9e-36 124.8 0.2 2.5e-35 122.5 0.2 2.0 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.8 AET37346.1 - 3.5e-20 71.7 1.9 1.2e-19 70.0 1.9 2.0 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 PI3Ka PF00613.20 AET37346.1 - 1.6e-06 27.6 0.7 4.7e-06 26.1 0.7 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 AET37346.1 - 0.011 15.1 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) DUF4600 PF15372.6 AET37346.1 - 0.069 13.6 0.1 0.19 12.1 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) U3snoRNP10 PF12397.8 AET37346.1 - 2.1 8.8 6.0 6.5 7.1 0.0 3.9 4 1 1 5 5 5 0 U3 small nucleolar RNA-associated protein 10 Tam41_Mmp37 PF09139.11 AET37347.1 - 7e-94 314.9 7.5 7.6e-87 291.8 0.9 2.1 1 1 1 2 2 2 2 Phosphatidate cytidylyltransferase, mitochondrial Ist1 PF03398.14 AET37348.1 - 4.6e-56 189.3 2.8 7.6e-56 188.5 2.8 1.4 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway DUF1664 PF07889.12 AET37348.1 - 0.13 12.3 7.6 2.3 8.3 1.3 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Snapin_Pallidin PF14712.6 AET37348.1 - 4.7 7.7 10.8 10 6.6 1.0 2.5 2 0 0 2 2 2 0 Snapin/Pallidin ADH_N PF08240.12 AET37349.1 - 1.1e-26 92.9 4.6 2.1e-26 91.9 4.6 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AET37349.1 - 6e-20 71.6 0.0 9.5e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 AET37349.1 - 6.2e-05 22.4 0.1 0.0001 21.7 0.1 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 AET37349.1 - 8.5e-05 22.0 0.1 0.00015 21.2 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 AET37349.1 - 0.00052 21.1 0.0 0.00083 20.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase GFO_IDH_MocA PF01408.22 AET37349.1 - 0.042 14.7 0.0 0.13 13.1 0.0 1.8 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Pyr_redox PF00070.27 AET37349.1 - 0.067 13.8 1.4 0.17 12.5 0.5 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF726 PF05277.12 AET37349.1 - 0.087 11.7 1.1 0.15 10.9 0.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF726) 3HCDH_N PF02737.18 AET37349.1 - 0.1 12.5 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UFD1 PF03152.14 AET37350.1 - 6.2e-68 227.6 0.0 7.9e-68 227.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 ArAE_2_N PF10337.9 AET37351.1 - 6.5e-52 177.1 0.9 6.5e-52 177.1 0.9 2.7 2 0 0 2 2 2 1 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 AET37351.1 - 3e-11 43.5 16.3 3e-11 43.5 16.3 2.6 2 1 0 2 2 2 1 Fusaric acid resistance protein-like ArAE_2 PF10334.9 AET37351.1 - 8.2e-05 22.5 0.0 0.00017 21.5 0.0 1.5 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 ALMT PF11744.8 AET37351.1 - 0.0029 16.5 9.8 0.055 12.3 5.5 2.3 2 0 0 2 2 2 2 Aluminium activated malate transporter CRAL_TRIO PF00650.20 AET37352.1 - 1.3e-38 132.2 0.0 2e-38 131.6 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 AET37352.1 - 3.4e-18 65.6 0.7 6.5e-18 64.7 0.7 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 AET37352.1 - 0.0016 18.6 0.0 0.0027 17.8 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain UBA_4 PF14555.6 AET37352.1 - 0.045 13.6 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 UBA-like domain DnaJ PF00226.31 AET37353.1 - 9.8e-16 57.6 1.0 1.8e-15 56.8 1.0 1.5 1 0 0 1 1 1 1 DnaJ domain Acyl-CoA_ox_N PF14749.6 AET37353.1 - 1.4 9.5 7.3 1.7 9.2 3.4 2.6 2 1 1 3 3 3 0 Acyl-coenzyme A oxidase N-terminal YIF1 PF03878.15 AET37354.1 - 2e-76 256.7 3.4 2.4e-76 256.4 3.4 1.1 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.17 AET37354.1 - 0.00081 19.1 0.7 0.00081 19.1 0.7 1.7 2 0 0 2 2 2 1 Yip1 domain DUF1744 PF08490.12 AET37355.1 - 2.1e-137 458.0 6.3 3.2e-137 457.4 6.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 AET37355.1 - 7.4e-79 265.3 3.8 2e-78 263.9 3.8 1.8 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 AET37355.1 - 2.5e-18 66.1 3.5 1.1e-13 50.7 0.2 3.7 4 1 0 4 4 4 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 AET37355.1 - 4.8e-07 29.7 0.5 2.4e-06 27.4 0.5 2.1 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 AET37355.1 - 0.00035 20.6 0.0 0.0018 18.3 0.0 2.3 1 0 0 1 1 1 1 RNase_H superfamily zinc_ribbon_10 PF10058.9 AET37355.1 - 0.31 10.8 1.6 1.1 9.0 1.6 1.9 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-CHY PF05495.12 AET37355.1 - 0.34 11.4 6.9 0.73 10.4 5.8 2.2 1 1 0 1 1 1 0 CHY zinc finger eIF-5_eIF-2B PF01873.17 AET37355.1 - 6.5 6.7 8.5 17 5.3 2.2 2.9 2 0 0 2 2 2 0 Domain found in IF2B/IF5 ORC5_C PF14630.6 AET37356.1 - 2e-60 204.8 0.3 2.5e-60 204.4 0.3 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 AET37356.1 - 5.5e-08 33.4 0.0 1.1e-07 32.3 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain CRAL_TRIO_2 PF13716.6 AET37356.1 - 0.0011 19.1 0.9 0.019 15.1 0.0 2.8 2 1 1 3 3 3 1 Divergent CRAL/TRIO domain AAA_22 PF13401.6 AET37356.1 - 0.13 12.5 0.0 0.35 11.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain GYF PF02213.16 AET37357.1 - 6.8e-08 32.1 2.4 6.8e-08 32.1 2.4 2.0 2 0 0 2 2 2 1 GYF domain Med15_fungi PF05397.12 AET37357.1 - 0.025 14.8 0.2 0.061 13.6 0.2 1.6 1 0 0 1 1 1 0 Mediator complex subunit 15 SID-1_RNA_chan PF13965.6 AET37357.1 - 2.7 6.3 6.2 0.098 11.1 0.3 1.6 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Yae1_N PF09811.9 AET37358.1 - 2.9e-07 30.0 5.1 1.4e-06 27.9 5.1 1.9 1 1 0 1 1 1 1 Essential protein Yae1, N terminal RTC4 PF14474.6 AET37359.1 - 4.2e-31 107.6 0.0 8.4e-31 106.6 0.0 1.5 1 0 0 1 1 1 1 RTC4-like domain HSP20 PF00011.21 AET37360.1 - 1.9e-20 72.9 0.1 2.9e-20 72.3 0.1 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 AET37360.1 - 1.7e-05 24.3 0.0 3.2e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 HSP20-like domain found in ArsA BON PF04972.17 AET37360.1 - 0.0047 17.2 0.1 1.2 9.5 0.0 2.4 2 0 0 2 2 2 2 BON domain MRP-L46 PF11788.8 AET37361.1 - 3e-39 134.4 0.7 4.1e-39 134.0 0.1 1.5 2 0 0 2 2 2 1 39S mitochondrial ribosomal protein L46 RRM_1 PF00076.22 AET37362.1 - 4.1e-07 29.7 0.0 8.5e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 AET37362.1 - 4.1e-05 24.3 0.0 0.00012 22.9 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RNA_bind PF08675.11 AET37362.1 - 0.0038 17.2 0.0 0.0083 16.1 0.0 1.5 1 0 0 1 1 1 1 RNA binding domain RRM_7 PF16367.5 AET37362.1 - 0.0087 16.2 0.0 0.15 12.2 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif CTK3 PF12243.8 AET37362.1 - 0.013 15.5 0.1 0.037 14.0 0.1 1.7 1 1 0 1 1 1 0 CTD kinase subunit gamma CTK3 Macoilin PF09726.9 AET37362.1 - 0.022 13.4 12.8 0.028 13.0 12.8 1.1 1 0 0 1 1 1 0 Macoilin family Lin-8 PF03353.15 AET37362.1 - 5.3 6.5 15.8 10 5.6 15.8 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Neur_chan_memb PF02932.16 AET37362.1 - 7.7 6.5 8.6 16 5.5 8.6 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AAA_23 PF13476.6 AET37363.1 - 8e-34 117.9 11.9 8e-34 117.9 11.9 8.5 1 1 0 4 4 2 1 AAA domain Rad50_zn_hook PF04423.14 AET37363.1 - 2.5e-15 56.1 3.3 2.5e-15 56.1 3.3 6.3 8 0 0 8 8 7 1 Rad50 zinc hook motif AAA_15 PF13175.6 AET37363.1 - 9.7e-11 42.0 0.1 9.7e-11 42.0 0.1 4.8 1 1 4 5 5 3 2 AAA ATPase domain AAA_21 PF13304.6 AET37363.1 - 2.2e-10 40.9 0.6 1.9e-06 27.9 0.1 4.9 4 1 0 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AET37363.1 - 3.2e-08 33.3 0.1 3.2e-08 33.3 0.1 3.1 2 1 0 2 2 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 AET37363.1 - 4.7e-06 26.7 0.0 1.2e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_13 PF13166.6 AET37363.1 - 0.0024 16.6 111.6 0.0068 15.1 0.0 6.7 4 1 2 6 6 6 4 AAA domain DUF1664 PF07889.12 AET37363.1 - 0.0026 17.8 3.4 0.0026 17.8 3.4 10.9 4 3 9 13 13 13 2 Protein of unknown function (DUF1664) AAA_29 PF13555.6 AET37363.1 - 0.0046 16.7 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Spectrin PF00435.21 AET37363.1 - 0.01 16.3 3.7 0.01 16.3 3.7 10.0 5 2 7 13 13 12 0 Spectrin repeat ABC_tran PF00005.27 AET37363.1 - 0.018 15.6 0.0 0.018 15.6 0.0 6.5 4 2 0 4 4 3 0 ABC transporter SCO1-SenC PF02630.14 AET37363.1 - 0.02 14.8 0.4 8.1 6.4 0.0 3.1 1 1 1 2 2 2 0 SCO1/SenC AAA_16 PF13191.6 AET37363.1 - 0.047 14.1 0.0 0.047 14.1 0.0 3.3 4 0 0 4 4 4 0 AAA ATPase domain AAA_25 PF13481.6 AET37363.1 - 0.23 11.0 1.3 4.4 6.8 0.0 3.4 3 0 0 3 3 3 0 AAA domain Laminin_II PF06009.12 AET37363.1 - 1.2 9.1 81.2 0.022 14.7 4.7 9.7 5 3 4 9 9 9 0 Laminin Domain II RNA_pol_I_A49 PF06870.12 AET37364.1 - 3.7e-118 394.7 1.0 4.3e-118 394.5 1.0 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor Zwint PF15556.6 AET37364.1 - 0.027 13.9 2.2 0.094 12.2 0.0 2.5 3 0 0 3 3 3 0 ZW10 interactor DnaJ PF00226.31 AET37365.1 - 1.3e-17 63.7 1.6 1.7e-17 63.3 1.6 1.2 1 0 0 1 1 1 1 DnaJ domain zf-CSL PF05207.13 AET37365.1 - 2.4e-17 62.4 0.3 4e-17 61.7 0.3 1.4 1 0 0 1 1 1 1 CSL zinc finger RPT PF13446.6 AET37365.1 - 0.00076 19.4 0.1 0.0023 17.8 0.0 1.7 1 1 1 2 2 2 1 A repeated domain in UCH-protein NAP PF00956.18 AET37366.1 - 3.4e-07 29.7 6.6 0.028 13.6 0.2 3.1 1 1 2 3 3 3 3 Nucleosome assembly protein (NAP) AHSA1 PF08327.11 AET37366.1 - 0.023 14.9 1.4 0.023 14.9 0.2 1.7 2 0 0 2 2 2 0 Activator of Hsp90 ATPase homolog 1-like protein SUI1 PF01253.22 AET37367.1 - 2.8e-26 91.8 0.1 3.6e-26 91.5 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2575 PF10837.8 AET37367.1 - 0.15 12.3 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) MATalpha_HMGbox PF04769.12 AET37368.1 - 8.4e-19 67.7 1.1 1.3e-18 67.1 1.1 1.3 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box Homeobox_KN PF05920.11 AET37369.1 - 5.6e-08 32.6 0.5 1e-07 31.7 0.5 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 AET37369.1 - 2.5e-06 27.2 0.4 8.1e-06 25.6 0.3 1.9 2 0 0 2 2 2 1 Homeodomain Homez PF11569.8 AET37369.1 - 0.00063 19.2 0.0 0.0015 18.0 0.0 1.6 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez Sec10 PF07393.11 AET37370.1 - 1.4e-55 189.0 8.2 1.7e-54 185.5 8.2 2.1 1 1 0 1 1 1 1 Exocyst complex component Sec10 PRP21_like_P PF12230.8 AET37371.1 - 5.5e-32 111.4 14.4 5.5e-32 111.4 14.4 2.5 2 1 0 2 2 2 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 AET37371.1 - 2.1e-07 30.8 5.2 6.3e-07 29.3 0.0 2.6 2 0 0 2 2 2 1 Surp module Plasmid_parti PF01672.16 AET37371.1 - 8.2 7.1 10.1 1.3 9.7 0.3 3.5 3 0 0 3 3 3 0 Putative plasmid partition protein zf-CCHC PF00098.23 AET37372.1 - 9.3e-52 170.9 55.7 2.1e-09 37.1 1.8 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 AET37372.1 - 1.9e-12 46.7 41.6 0.007 16.1 0.4 7.1 6 1 1 7 7 7 7 Zinc knuckle zf-CCHC_5 PF14787.6 AET37372.1 - 0.0002 21.0 36.0 0.19 11.4 1.0 7.0 4 1 3 7 7 7 4 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 AET37372.1 - 0.00022 21.1 42.3 2.6 8.1 1.2 7.1 1 1 5 6 6 6 6 Zinc knuckle zf-C2H2_10 PF16588.5 AET37372.1 - 0.011 15.4 2.7 0.011 15.4 2.7 6.5 7 0 0 7 7 7 0 C2H2 zinc-finger zf-CCHC_2 PF13696.6 AET37372.1 - 0.034 14.0 1.3 0.034 14.0 1.3 7.3 7 0 0 7 7 7 0 Zinc knuckle Pterin_bind PF00809.22 AET37373.1 - 2.2e-59 201.1 0.3 1.4e-58 198.5 0.3 2.0 1 1 0 1 1 1 1 Pterin binding enzyme FolB PF02152.18 AET37373.1 - 5.1e-35 120.4 1.7 1.8e-17 63.9 0.0 3.3 3 0 0 3 3 3 2 Dihydroneopterin aldolase HPPK PF01288.20 AET37373.1 - 2.5e-32 111.7 0.0 5.9e-32 110.5 0.0 1.7 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) FAD_binding_3 PF01494.19 AET37374.1 - 3.4e-17 62.7 0.1 1.4e-07 31.1 0.0 3.1 3 0 0 3 3 3 3 FAD binding domain Lycopene_cycl PF05834.12 AET37374.1 - 1.1e-05 24.8 0.1 0.0014 17.8 0.1 2.9 3 0 0 3 3 3 1 Lycopene cyclase protein Thi4 PF01946.17 AET37374.1 - 0.0049 16.1 0.0 0.013 14.7 0.0 1.6 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 AET37374.1 - 0.005 16.1 0.0 0.011 15.1 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 AET37374.1 - 0.0088 15.7 0.1 0.028 14.0 0.1 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 AET37374.1 - 0.012 15.8 0.1 0.023 14.9 0.1 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 AET37374.1 - 0.016 14.1 0.1 0.25 10.2 0.1 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 AET37374.1 - 0.017 14.4 0.0 0.044 13.0 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AET37374.1 - 0.024 13.7 0.1 0.042 12.9 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain SE PF08491.10 AET37374.1 - 0.059 12.4 0.0 0.086 11.9 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase HI0933_like PF03486.14 AET37374.1 - 0.16 10.7 0.0 0.24 10.1 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein RRM_1 PF00076.22 AET37375.1 - 8.2e-17 60.8 0.1 1.6e-16 59.9 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pro_isomerase PF00160.21 AET37375.1 - 7.8e-14 52.2 0.0 1.1e-13 51.8 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD NSs PF11073.8 AET37375.1 - 0.011 15.3 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 0 Rift valley fever virus non structural protein (NSs) like OB_RNB PF08206.11 AET37375.1 - 0.063 13.0 0.7 1.6 8.5 0.1 2.3 2 0 0 2 2 2 0 Ribonuclease B OB domain RRM_5 PF13893.6 AET37375.1 - 0.066 12.8 0.0 0.15 11.7 0.0 1.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 AET37375.1 - 0.16 12.0 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif PGAP1 PF07819.13 AET37376.1 - 2.6e-06 27.4 0.0 5.5e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 AET37376.1 - 2.2e-05 24.4 0.0 6.2e-05 23.0 0.0 1.8 1 1 0 1 1 1 1 Palmitoyl protein thioesterase DUF676 PF05057.14 AET37376.1 - 4.9e-05 22.9 0.0 8.6e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF915 PF06028.11 AET37376.1 - 9.3e-05 21.9 0.0 0.0011 18.4 0.0 2.6 4 0 0 4 4 4 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_1 PF00561.20 AET37376.1 - 0.00066 19.4 0.1 0.0023 17.6 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold LCAT PF02450.15 AET37376.1 - 0.0038 16.5 0.0 0.0064 15.7 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 AET37376.1 - 0.092 13.3 0.0 0.17 12.4 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family VASt PF16016.5 AET37377.1 - 8.5e-15 55.5 7.4 2.3e-14 54.0 0.6 3.4 4 0 0 4 4 4 1 VAD1 Analog of StAR-related lipid transfer domain BAR_3 PF16746.5 AET37377.1 - 2.8e-10 40.3 0.9 9.8e-10 38.5 0.9 2.0 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 AET37377.1 - 5.1e-08 33.4 1.2 2e-07 31.5 0.4 2.5 2 0 0 2 2 2 1 PH domain HMA PF00403.26 AET37378.1 - 4.7e-08 33.3 0.1 5.8e-08 33.1 0.1 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain Allantoicase PF03561.15 AET37379.1 - 9.7e-91 301.2 0.1 1.7e-46 157.8 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat BPS1 PF05633.11 AET37379.1 - 0.15 11.1 0.0 0.2 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein BYPASS1-related Methyltransf_16 PF10294.9 AET37380.1 - 2.5e-16 59.9 0.3 7.7e-16 58.3 0.0 1.8 2 0 0 2 2 2 1 Lysine methyltransferase Gly_acyl_tr_N PF06021.11 AET37381.1 - 0.22 11.6 8.7 0.043 13.9 3.1 2.1 2 0 0 2 2 2 0 Aralkyl acyl-CoA:amino acid N-acyltransferase DUF349 PF03993.12 AET37381.1 - 0.22 11.8 7.2 0.61 10.4 7.2 1.8 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) ssDNA-exonuc_C PF10141.9 AET37381.1 - 0.52 9.9 10.8 4.6 6.8 0.5 3.6 2 1 1 3 3 3 0 Single-strand DNA-specific exonuclease, C terminal domain DUF4407 PF14362.6 AET37381.1 - 1.1 8.6 8.4 0.092 12.1 3.9 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF5595 PF18077.1 AET37381.1 - 1.5 9.0 17.4 10 6.3 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5595) Phage_Mu_Gam PF07352.12 AET37381.1 - 1.5 8.7 10.5 3.7 7.4 10.0 1.8 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein GAS PF13851.6 AET37381.1 - 1.8 7.9 25.6 0.18 11.2 5.4 3.1 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 AET37381.1 - 3.3 7.8 7.3 4.6 7.3 5.2 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Cauli_AT PF03233.13 AET37381.1 - 3.6 7.5 10.8 0.18 11.7 4.2 2.2 2 1 1 3 3 3 0 Aphid transmission protein MCC-bdg_PDZ PF10506.9 AET37381.1 - 4.9 7.3 14.1 0.52 10.4 2.0 3.8 2 1 1 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome SOGA PF11365.8 AET37381.1 - 5.3 8.2 20.4 0.33 12.1 3.3 3.9 3 1 1 4 4 4 0 Protein SOGA Calici_MSP PF05752.11 AET37381.1 - 5.3 6.8 5.8 4.2 7.2 0.3 2.4 2 0 0 2 2 2 0 Calicivirus minor structural protein PRKG1_interact PF15898.5 AET37381.1 - 5.7 7.9 20.5 10 7.1 12.7 2.8 2 2 0 2 2 2 0 cGMP-dependent protein kinase interacting domain ADIP PF11559.8 AET37381.1 - 7.9 6.6 24.6 5.6 7.0 6.4 2.8 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Dus PF01207.17 AET37382.1 - 4.3e-80 269.1 0.0 5.5e-80 268.8 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Peptidase_M28 PF04389.17 AET37383.1 - 4.8e-20 72.1 0.0 8.6e-20 71.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.15 AET37383.1 - 3.2e-19 69.2 0.0 5.7e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.22 AET37383.1 - 3.3e-09 36.7 0.0 3.5e-08 33.3 0.0 2.4 1 1 0 1 1 1 1 PA domain DUF1415 PF07209.12 AET37383.1 - 0.0059 16.4 0.2 0.017 14.8 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1415) Peptidase_M20 PF01546.28 AET37383.1 - 0.0072 16.0 0.0 0.049 13.3 0.0 2.1 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 NumbF PF06311.12 AET37383.1 - 0.11 13.0 0.3 20 5.8 0.1 2.5 2 0 0 2 2 2 0 NUMB domain Pro_isomerase PF00160.21 AET37384.1 - 3.5e-47 160.6 0.1 4.2e-47 160.4 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.6 AET37384.1 - 0.15 12.1 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin domain ENTH PF01417.20 AET37385.1 - 1.8e-40 137.8 0.0 2.8e-40 137.2 0.0 1.3 1 0 0 1 1 1 1 ENTH domain Herpes_UL17 PF04559.12 AET37385.1 - 0.12 11.2 0.1 0.25 10.1 0.0 1.5 2 0 0 2 2 2 0 Herpesvirus UL17 protein Sybindin PF04099.12 AET37386.1 - 1.6e-20 73.5 0.1 1.9e-20 73.2 0.1 1.1 1 0 0 1 1 1 1 Sybindin-like family Zn_clus PF00172.18 AET37387.1 - 0.0025 17.9 7.9 0.0045 17.1 7.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HMG-CoA_red PF00368.18 AET37388.1 - 1.5e-142 475.0 0.1 1.9e-142 474.6 0.1 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 AET37388.1 - 2.2e-40 138.1 2.1 5.1e-40 136.9 2.1 1.7 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 AET37388.1 - 6.9e-08 32.5 7.3 6.9e-08 32.5 7.3 1.9 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation FKBP_C PF00254.28 AET37389.1 - 3.1e-28 97.9 0.7 8.9e-28 96.5 0.2 2.0 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 AET37389.1 - 1.9e-22 79.8 8.4 1.9e-22 79.8 8.4 3.0 2 1 0 2 2 2 1 Nucleoplasmin-like domain CPSF100_C PF13299.6 AET37389.1 - 0.31 11.2 23.0 1 9.5 8.3 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal GAGA_bind PF06217.12 AET37389.1 - 1.1 9.5 16.7 1.6 8.9 7.0 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family eIF3_subunit PF08597.10 AET37389.1 - 1.7 8.5 58.2 0.049 13.5 29.8 2.3 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit Tim54 PF11711.8 AET37389.1 - 1.7 7.3 27.4 0.088 11.6 10.5 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 RNA_pol_Rpc4 PF05132.14 AET37389.1 - 2.7 8.4 24.6 4.7 7.6 7.6 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 AAA_11 PF13086.6 AET37389.1 - 8.3 6.1 16.7 2.7 7.7 3.9 2.2 2 0 0 2 2 2 0 AAA domain DUF5308 PF17233.2 AET37389.1 - 8.8 6.5 6.7 8.5 6.6 0.8 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5308) Ribosomal_L6e PF01159.19 AET37390.1 - 3.1e-39 133.9 3.7 4.6e-39 133.4 3.7 1.3 1 0 0 1 1 1 1 Ribosomal protein L6e C2 PF00168.30 AET37391.1 - 2.9e-50 168.9 0.0 3.7e-20 72.1 0.0 5.9 6 0 0 6 6 6 5 C2 domain Dor1 PF04124.12 AET37392.1 - 1.2e-21 76.8 16.2 8.6e-20 70.7 16.2 2.1 1 1 0 1 1 1 1 Dor1-like family Sec5 PF15469.6 AET37392.1 - 0.00023 21.0 3.2 0.00041 20.2 0.5 2.5 1 1 1 2 2 2 1 Exocyst complex component Sec5 vATP-synt_AC39 PF01992.16 AET37393.1 - 1.4e-106 356.9 4.5 1.5e-106 356.7 4.5 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit OspD PF03207.13 AET37393.1 - 0.019 14.3 0.1 0.041 13.2 0.1 1.5 1 0 0 1 1 1 0 Borrelia outer surface protein D (OspD) cNMP_binding PF00027.29 AET37394.1 - 9.8e-37 124.9 0.1 1.1e-18 67.1 0.0 2.8 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain F-box PF00646.33 AET37394.1 - 6.3e-07 29.1 1.4 2.8e-06 27.1 1.4 2.2 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 AET37394.1 - 8.3e-06 25.6 0.5 2.7e-05 24.0 0.5 1.9 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 AET37394.1 - 0.00014 22.2 0.8 0.00014 22.2 0.8 6.1 6 1 1 7 7 7 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 AET37394.1 - 0.01 15.8 18.6 2.3 8.5 0.1 6.9 7 0 0 7 7 7 0 Leucine Rich repeat Dynamin_M PF01031.20 AET37394.1 - 0.012 14.9 0.5 0.026 13.7 0.1 1.7 2 0 0 2 2 2 0 Dynamin central region Cyt-b5 PF00173.28 AET37395.1 - 1e-06 28.8 0.0 2e-06 27.8 0.0 1.6 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Hexokinase_2 PF03727.16 AET37396.1 - 1.4e-12 47.6 0.0 3.8e-11 42.9 0.0 2.1 1 1 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 AET37396.1 - 3.4e-12 46.7 0.1 6.4e-12 45.8 0.1 1.4 1 0 0 1 1 1 1 Hexokinase CoA_binding_2 PF13380.6 AET37397.1 - 7e-23 81.3 0.0 1.1e-22 80.7 0.0 1.3 1 1 0 1 1 1 1 CoA binding domain Zn_clus PF00172.18 AET37398.1 - 1.2e-07 31.7 8.9 2.1e-07 31.0 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Med9 PF07544.13 AET37398.1 - 0.081 13.0 4.5 0.21 11.7 3.6 2.2 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 FeoB_Cyto PF17910.1 AET37398.1 - 0.11 13.1 2.3 3.3 8.3 0.2 3.4 2 1 0 2 2 2 0 FeoB cytosolic helical domain BAR PF03114.18 AET37399.1 - 9.1e-14 51.7 0.8 2.7e-13 50.1 0.8 1.7 1 1 0 1 1 1 1 BAR domain SH3_9 PF14604.6 AET37399.1 - 4.1e-13 49.0 0.1 9.8e-13 47.7 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 AET37399.1 - 1.8e-12 46.7 0.1 3.6e-12 45.7 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 AET37399.1 - 1.9e-10 40.3 0.0 3.3e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain TMPIT PF07851.13 AET37399.1 - 0.034 13.4 9.5 0.12 11.6 8.2 1.9 2 0 0 2 2 2 0 TMPIT-like protein DUF948 PF06103.11 AET37399.1 - 0.12 12.6 1.3 21 5.4 0.1 3.3 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) CREPT PF16566.5 AET37399.1 - 0.28 11.4 6.6 0.46 10.7 5.6 1.8 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Snapin_Pallidin PF14712.6 AET37399.1 - 7.8 7.0 9.1 14 6.2 6.4 2.7 2 1 1 3 3 3 0 Snapin/Pallidin Dak1 PF02733.17 AET37400.1 - 5.8e-110 367.0 0.2 7.6e-110 366.6 0.2 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 AET37400.1 - 2.1e-45 154.7 0.0 3.7e-45 154.0 0.0 1.4 1 0 0 1 1 1 1 DAK2 domain SSrecog PF03531.14 AET37401.1 - 1.7e-28 98.3 0.5 2e-26 91.7 0.0 3.1 3 0 0 3 3 3 1 Structure-specific recognition protein (SSRP1) POB3_N PF17292.2 AET37401.1 - 1.3e-27 96.0 0.1 3.3e-25 88.3 0.0 2.6 2 0 0 2 2 2 2 POB3-like N-terminal PH domain Rtt106 PF08512.12 AET37401.1 - 1.8e-26 92.4 0.1 6.8e-24 84.1 0.0 2.9 3 0 0 3 3 3 2 Histone chaperone Rttp106-like DUF4827 PF16109.5 AET37401.1 - 0.081 12.9 0.3 0.21 11.6 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4827) COPIIcoated_ERV PF07970.12 AET37402.1 - 2.5e-27 96.2 0.0 3.6e-27 95.6 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 AET37402.1 - 9.8e-25 86.7 1.1 1.2e-24 86.4 0.0 1.7 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) GpcrRhopsn4 PF10192.9 AET37403.1 - 0.033 13.6 7.8 0.057 12.8 2.8 2.7 3 1 0 3 3 3 0 Rhodopsin-like GPCR transmembrane domain Ninjurin PF04923.12 AET37403.1 - 0.64 10.0 4.1 1.9 8.5 2.2 2.4 2 0 0 2 2 2 0 Ninjurin SUR7 PF06687.12 AET37404.1 - 3.9e-10 39.7 8.6 6.7e-10 39.0 8.6 1.4 1 0 0 1 1 1 1 SUR7/PalI family Transp_cyt_pur PF02133.15 AET37404.1 - 0.00069 18.5 0.5 0.0013 17.6 0.5 1.5 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Orf78 PF06024.12 AET37404.1 - 0.41 11.0 5.1 0.14 12.5 0.5 2.3 1 1 1 2 2 2 0 Orf78 (ac78) AAA_lid_10 PF17872.1 AET37405.1 - 2.8e-33 114.0 0.0 8.5e-33 112.4 0.0 1.9 1 0 0 1 1 1 1 AAA lid domain AAA PF00004.29 AET37405.1 - 4.8e-20 72.3 0.0 1e-19 71.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AET37405.1 - 1e-08 35.5 0.0 6.6e-08 32.9 0.0 2.4 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 AET37405.1 - 1.1e-08 35.7 0.0 1.1e-07 32.4 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain BAH PF01426.18 AET37405.1 - 2.8e-06 27.2 0.2 1e-05 25.4 0.2 2.0 1 0 0 1 1 1 1 BAH domain ATPase_2 PF01637.18 AET37405.1 - 0.0001 22.3 0.1 0.0001 22.3 0.1 3.3 3 2 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_18 PF13238.6 AET37405.1 - 0.028 15.0 0.1 0.16 12.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 AET37405.1 - 0.029 14.4 0.5 0.27 11.3 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 AET37405.1 - 0.045 14.1 0.0 0.095 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 AET37405.1 - 0.085 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 AET37405.1 - 0.12 12.7 0.0 1.7 9.1 0.0 2.8 2 0 0 2 2 2 0 RNA helicase Ras PF00071.22 AET37406.1 - 6.3e-30 103.9 0.1 7.8e-30 103.6 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET37406.1 - 1.8e-21 76.6 0.0 1.2e-20 73.9 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET37406.1 - 8.6e-05 22.1 0.1 0.00011 21.7 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DLIC PF05783.11 AET37406.1 - 0.00029 19.8 0.1 0.4 9.4 0.1 2.1 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) Gtr1_RagA PF04670.12 AET37406.1 - 0.00061 19.2 0.1 0.00078 18.9 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AET37406.1 - 0.067 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 AET37406.1 - 0.08 12.7 0.3 0.6 9.9 0.3 2.2 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 AET37406.1 - 0.094 12.1 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Ribosomal_S3Ae PF01015.18 AET37407.1 - 3.8e-86 287.8 5.1 4.5e-86 287.6 5.1 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family DLP_helical PF18709.1 AET37407.1 - 0.0057 15.9 0.4 0.0089 15.3 0.4 1.3 1 0 0 1 1 1 1 Dynamin-like helical domain Abhydro_lipase PF04083.16 AET37407.1 - 0.033 13.8 0.0 0.14 11.8 0.0 2.0 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region THOC7 PF05615.13 AET37408.1 - 2.1e-05 24.8 1.4 2.1e-05 24.8 1.4 2.2 2 0 0 2 2 2 1 Tho complex subunit 7 Tsc35 PF15079.6 AET37408.1 - 0.037 13.6 0.6 0.037 13.6 0.6 2.3 1 1 0 2 2 2 0 Testis-specific protein 35 HIP1_clath_bdg PF16515.5 AET37408.1 - 0.043 14.4 2.0 0.043 14.4 2.0 2.9 3 1 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 UPF0242 PF06785.11 AET37408.1 - 0.23 11.5 8.6 0.14 12.3 2.2 2.8 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus DUF5082 PF16888.5 AET37408.1 - 1.7 8.9 7.4 4.9 7.4 2.6 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) Sec39 PF08314.11 AET37409.1 - 2.4e-84 284.3 2.3 2.2e-67 228.2 0.7 2.1 2 0 0 2 2 2 2 Secretory pathway protein Sec39 PIF1 PF05970.14 AET37410.1 - 1.4e-68 231.8 2.3 1.5e-52 179.0 0.3 2.2 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 AET37410.1 - 4.1e-18 65.8 0.0 6.9e-18 65.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AET37410.1 - 1.7e-09 38.2 0.0 5.1e-09 36.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AET37410.1 - 0.00021 21.6 0.0 0.00064 20.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 AET37410.1 - 0.00056 19.7 0.0 0.011 15.5 0.0 2.6 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain T2SSE PF00437.20 AET37410.1 - 0.0029 16.7 0.0 0.0051 15.9 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein Herpes_Helicase PF02689.14 AET37410.1 - 0.0034 15.4 0.1 0.014 13.4 0.0 1.8 2 0 0 2 2 2 1 Helicase AAA_7 PF12775.7 AET37410.1 - 0.014 14.9 0.0 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 AET37410.1 - 0.076 12.4 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA PF00004.29 AET37410.1 - 0.078 13.4 0.1 0.3 11.5 0.1 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 AET37410.1 - 0.08 13.3 0.0 0.33 11.4 0.0 2.1 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 AET37410.1 - 0.11 12.4 0.1 0.25 11.3 0.1 1.6 1 0 0 1 1 1 0 NACHT domain ATPase PF06745.13 AET37410.1 - 0.28 10.5 3.0 19 4.5 0.0 3.2 3 0 0 3 3 3 0 KaiC ATPase_2 PF01637.18 AET37410.1 - 0.45 10.4 0.0 0.45 10.4 0.0 2.9 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea MRP-L47 PF06984.13 AET37411.1 - 5.4e-24 84.1 2.7 1.5e-23 82.7 2.7 1.8 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) DUF4110 PF13422.6 AET37411.1 - 1.8 8.7 9.0 0.27 11.3 0.9 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4110) LSM PF01423.22 AET37412.1 - 7.7e-19 67.2 0.1 8.6e-19 67.0 0.1 1.1 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 AET37412.1 - 0.0016 18.5 0.0 0.0027 17.8 0.0 1.6 1 1 0 1 1 1 1 RimP C-terminal SH3 domain Hfq PF17209.3 AET37412.1 - 0.14 11.8 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Hfq protein cNMP_binding PF00027.29 AET37413.1 - 5.6e-26 90.4 0.3 6.3e-11 42.2 0.0 5.3 4 1 0 4 4 4 3 Cyclic nucleotide-binding domain Patatin PF01734.22 AET37413.1 - 4.8e-19 69.4 1.5 1.9e-12 47.8 1.1 2.7 2 0 0 2 2 2 2 Patatin-like phospholipase Fibrinogen_BP PF08017.11 AET37413.1 - 0.032 12.7 1.8 0.052 12.0 1.8 1.2 1 0 0 1 1 1 0 Fibrinogen binding protein Aminotran_3 PF00202.21 AET37414.1 - 7.5e-120 400.3 0.0 8.6e-120 400.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 AET37414.1 - 7.8e-05 22.1 0.0 0.00017 21.0 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase OAM_dimer PF16554.5 AET37414.1 - 0.18 12.3 0.1 1 9.8 0.0 2.2 3 0 0 3 3 3 0 Dimerisation domain of d-ornithine 4,5-aminomutase RNR_inhib PF08591.10 AET37415.1 - 1.1e-06 29.8 1.6 9.9e-06 26.8 0.0 2.4 2 1 1 3 3 3 1 Ribonucleotide reductase inhibitor UCH PF00443.29 AET37416.1 - 3.8e-31 108.5 4.7 1.5e-29 103.3 0.6 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase SH3_1 PF00018.28 AET37417.1 - 2.5e-24 84.6 0.0 6.2e-12 44.9 0.0 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 AET37417.1 - 1e-15 57.3 0.1 9.8e-11 41.4 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.24 AET37417.1 - 4.6e-14 52.4 0.0 7.8e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 AET37417.1 - 1.7e-10 40.4 0.0 1e-09 37.9 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain PB1 PF00564.24 AET37417.1 - 0.0039 17.1 0.0 0.0084 16.0 0.0 1.6 1 0 0 1 1 1 1 PB1 domain SelB-wing_2 PF09106.11 AET37417.1 - 0.0073 16.5 0.0 3 8.1 0.0 2.6 2 0 0 2 2 2 2 Elongation factor SelB, winged helix VPS9 PF02204.18 AET37419.1 - 1.3e-17 63.9 1.5 2.9e-17 62.8 1.5 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain polyprenyl_synt PF00348.17 AET37420.1 - 3.7e-56 190.0 0.0 4.6e-56 189.7 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase DER1 PF04511.15 AET37421.1 - 0.0018 18.3 6.7 0.0059 16.6 6.7 1.8 1 1 0 1 1 1 1 Der1-like family HILPDA PF15220.6 AET37421.1 - 4.3 7.5 5.3 37 4.6 0.6 2.9 2 1 1 3 3 3 0 Hypoxia-inducible lipid droplet-associated MCM PF00493.23 AET37423.1 - 4.6e-103 343.1 0.0 7.6e-103 342.4 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AET37423.1 - 2.3e-32 111.5 1.5 4.4e-32 110.6 1.5 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AET37423.1 - 3.5e-22 78.6 2.1 1.2e-21 76.9 2.1 2.0 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 AET37423.1 - 3.6e-15 56.4 0.2 1.2e-14 54.8 0.2 2.0 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 AET37423.1 - 4.2e-07 29.6 0.0 7.5e-05 22.2 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 AET37423.1 - 2.2e-06 27.7 0.0 1.6e-05 24.9 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_lid_2 PF17863.1 AET37423.1 - 0.0007 19.4 0.1 0.0016 18.2 0.1 1.6 1 0 0 1 1 1 1 AAA lid domain Mg_chelatase_C PF13335.6 AET37423.1 - 0.00091 19.8 1.3 0.003 18.1 0.6 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI C-terminal AAA_3 PF07726.11 AET37423.1 - 0.028 14.3 0.0 0.11 12.4 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AET37423.1 - 0.087 13.2 0.3 4.9 7.5 0.0 3.3 2 1 0 3 3 3 0 AAA ATPase domain CT_C_D PF02682.16 AET37423.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Carboxyltransferase domain, subdomain C and D zf-HYPF PF07503.12 AET37423.1 - 0.14 11.9 0.2 0.41 10.5 0.2 1.8 1 0 0 1 1 1 0 HypF finger VPS28 PF03997.12 AET37425.1 - 7.4e-75 250.8 1.9 8.6e-75 250.6 1.9 1.0 1 0 0 1 1 1 1 VPS28 protein Pro_isomerase PF00160.21 AET37426.1 - 3.2e-06 27.5 0.0 4e-05 23.9 0.0 2.5 2 2 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RNA_pol_Rpc82 PF05645.13 AET37426.1 - 0.02 14.6 0.1 0.024 14.4 0.1 1.2 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 NIF PF03031.18 AET37427.1 - 3.4e-39 134.1 0.0 6.6e-39 133.2 0.0 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase F-box PF00646.33 AET37428.1 - 0.043 13.7 0.0 0.19 11.7 0.0 2.2 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 AET37428.1 - 0.065 13.1 0.0 0.18 11.7 0.0 1.8 1 0 0 1 1 1 0 F-box-like Abhydrolase_6 PF12697.7 AET37429.1 - 4.8e-10 40.4 0.0 6.7e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AET37429.1 - 3.3e-09 36.4 0.0 6.8e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AET37429.1 - 3.1e-08 33.6 0.0 3.1e-08 33.6 0.0 3.2 3 0 0 3 3 3 1 alpha/beta hydrolase fold LIDHydrolase PF10230.9 AET37429.1 - 0.06 12.9 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Say1_Mug180 PF10340.9 AET37430.1 - 3.1e-36 125.0 0.1 3.4e-36 124.9 0.1 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 AET37430.1 - 8.2e-10 38.9 0.0 1.4e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold PGP_phosphatase PF09419.10 AET37430.1 - 0.098 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase Glyco_transf_15 PF01793.16 AET37431.1 - 1.5e-114 382.6 7.9 1.9e-114 382.3 7.9 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase CorA PF01544.18 AET37432.1 - 0.00031 20.2 6.3 0.00062 19.2 6.3 1.5 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF443 PF04276.12 AET37432.1 - 0.019 14.8 3.2 0.038 13.8 3.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF443) FTR1 PF03239.14 AET37433.1 - 2.1e-96 322.7 10.6 2.5e-96 322.5 10.6 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family TM231 PF10149.9 AET37433.1 - 0.071 12.4 1.3 7.5 5.8 0.1 2.5 2 0 0 2 2 2 0 Transmembrane protein 231 DUF3180 PF11377.8 AET37433.1 - 0.3 11.2 0.1 0.3 11.2 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3180) Amidase PF01425.21 AET37434.1 - 1.3e-92 311.1 0.0 2e-92 310.5 0.0 1.2 1 0 0 1 1 1 1 Amidase CT_A_B PF02626.15 AET37434.1 - 4e-85 285.6 0.0 6.8e-85 284.9 0.0 1.4 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B CPSase_L_D2 PF02786.17 AET37434.1 - 3.3e-64 216.3 0.0 6.5e-64 215.3 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CT_C_D PF02682.16 AET37434.1 - 2.4e-46 158.0 0.0 4.9e-46 157.0 0.0 1.5 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Biotin_carb_N PF00289.22 AET37434.1 - 1.2e-40 138.5 0.1 5.1e-40 136.4 0.0 2.2 2 0 0 2 2 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 AET37434.1 - 1.1e-33 115.5 0.0 3.4e-33 114.0 0.0 1.9 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 AET37434.1 - 1.8e-17 62.9 1.4 4.6e-17 61.6 1.4 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 AET37434.1 - 1.1e-11 44.6 0.0 2.7e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 AET37434.1 - 1.9e-05 24.3 0.0 4.1e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 AET37434.1 - 0.00039 20.2 0.2 1.3 8.9 0.0 3.0 1 1 1 2 2 2 2 Biotin-lipoyl like RnfC_N PF13375.6 AET37434.1 - 0.00086 19.2 0.1 0.0036 17.2 0.1 2.0 2 0 0 2 2 2 1 RnfC Barrel sandwich hybrid domain ATP-grasp_3 PF02655.14 AET37434.1 - 0.004 17.2 0.0 0.01 15.9 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain NUDIX_5 PF16705.5 AET37434.1 - 0.04 13.7 0.0 0.083 12.6 0.0 1.4 1 0 0 1 1 1 0 NUDIX, or N-terminal NPxY motif-rich, region of KRIT ATP-grasp_5 PF13549.6 AET37434.1 - 0.078 12.4 0.0 0.18 11.2 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain NQRA PF05896.11 AET37434.1 - 0.16 11.4 0.1 0.28 10.6 0.1 1.3 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) GCV_H PF01597.19 AET37434.1 - 0.2 11.6 0.7 1.5 8.7 0.1 2.4 2 0 0 2 2 2 0 Glycine cleavage H-protein AMP-binding PF00501.28 AET37435.1 - 8.6e-76 255.2 0.0 1.1e-75 254.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Glutaredoxin PF00462.24 AET37436.1 - 1.8e-17 63.3 0.0 3.2e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Exo5 PF09810.9 AET37437.1 - 1.7e-59 202.2 0.0 2.9e-59 201.4 0.0 1.3 1 0 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease Cas_Cas4 PF01930.17 AET37437.1 - 0.00081 19.5 1.3 0.036 14.2 0.0 2.7 2 1 0 2 2 2 1 Domain of unknown function DUF83 PDDEXK_1 PF12705.7 AET37437.1 - 0.011 15.7 2.5 2.7 7.8 0.2 3.0 3 0 0 3 3 3 0 PD-(D/E)XK nuclease superfamily UAA PF08449.11 AET37438.1 - 2.9e-12 46.4 19.0 3.6e-12 46.1 19.0 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 AET37438.1 - 1.2e-07 32.0 27.6 0.00075 19.7 9.1 2.1 2 0 0 2 2 2 2 EamA-like transporter family Multi_Drug_Res PF00893.19 AET37438.1 - 2.3 8.9 12.0 1.1 9.9 3.0 3.1 3 1 0 3 3 3 0 Small Multidrug Resistance protein Nse5 PF08691.10 AET37439.1 - 1.9e-27 96.2 15.5 2.4e-27 95.8 15.5 1.2 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 SieB PF14163.6 AET37439.1 - 0.083 12.4 0.1 0.24 10.9 0.1 1.7 1 0 0 1 1 1 0 Super-infection exclusion protein B Hydrolase PF00702.26 AET37440.1 - 9.9e-08 32.5 0.0 8.1e-07 29.5 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AET37440.1 - 2.8e-07 30.8 0.0 4.4e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Cas_DxTHG PF09455.10 AET37441.1 - 0.057 13.0 2.5 0.083 12.5 2.1 1.5 1 1 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family Mucin15 PF15672.5 AET37441.1 - 0.1 12.0 1.4 0.29 10.6 0.1 2.0 2 0 0 2 2 2 0 Cell-membrane associated Mucin15 ABC_tran PF00005.27 AET37442.1 - 1.6e-49 167.9 0.0 1.3e-24 87.3 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 AET37442.1 - 1.5e-22 79.4 1.0 1.5e-22 79.4 1.0 3.2 3 0 0 3 3 2 1 ABC transporter AAA_21 PF13304.6 AET37442.1 - 7.1e-19 68.7 6.8 1.5e-06 28.3 0.0 4.5 2 2 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AET37442.1 - 3.1e-08 33.3 7.8 0.76 9.2 0.0 5.4 4 1 1 6 6 6 4 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 AET37442.1 - 7.1e-08 32.1 0.0 0.0047 16.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 AET37442.1 - 1.9e-07 31.4 0.0 0.098 12.9 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 AET37442.1 - 5.1e-07 30.3 0.3 0.042 14.4 0.0 4.0 4 1 0 4 4 3 2 AAA domain RsgA_GTPase PF03193.16 AET37442.1 - 5.8e-07 29.6 0.3 0.001 19.0 0.0 3.0 3 0 0 3 3 3 1 RsgA GTPase AAA_33 PF13671.6 AET37442.1 - 1.8e-06 28.2 0.8 0.046 13.9 0.0 3.6 4 0 0 4 4 3 2 AAA domain AAA_23 PF13476.6 AET37442.1 - 3.3e-06 27.7 12.3 0.047 14.2 0.0 4.3 5 0 0 5 5 4 2 AAA domain MMR_HSR1 PF01926.23 AET37442.1 - 4.6e-06 26.7 0.1 0.014 15.4 0.0 3.4 3 0 0 3 3 3 1 50S ribosome-binding GTPase AAA_16 PF13191.6 AET37442.1 - 4.8e-06 27.1 0.0 0.01 16.2 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain NACHT PF05729.12 AET37442.1 - 3.1e-05 24.0 0.4 0.19 11.6 0.0 3.0 3 0 0 3 3 3 2 NACHT domain AAA_28 PF13521.6 AET37442.1 - 6.7e-05 23.2 0.1 0.29 11.4 0.0 2.9 3 0 0 3 3 3 2 AAA domain RNA_helicase PF00910.22 AET37442.1 - 9.6e-05 22.7 0.0 0.63 10.5 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 AET37442.1 - 0.00013 22.0 0.1 1.3 9.0 0.0 3.7 3 0 0 3 3 3 2 AAA domain AAA PF00004.29 AET37442.1 - 0.00013 22.4 2.7 0.27 11.7 0.1 3.6 4 2 0 4 4 2 2 ATPase family associated with various cellular activities (AAA) MCM PF00493.23 AET37442.1 - 0.00023 20.3 0.0 0.18 10.8 0.0 2.4 2 0 0 2 2 2 2 MCM P-loop domain NB-ARC PF00931.22 AET37442.1 - 0.00057 19.1 0.0 0.6 9.2 0.0 3.3 3 0 0 3 3 3 1 NB-ARC domain AAA_24 PF13479.6 AET37442.1 - 0.00066 19.5 1.0 0.6 9.8 0.0 3.2 4 0 0 4 4 3 1 AAA domain AAA_15 PF13175.6 AET37442.1 - 0.00079 19.2 11.1 0.094 12.4 0.0 3.5 3 1 1 4 4 4 2 AAA ATPase domain Rad17 PF03215.15 AET37442.1 - 0.0021 18.0 0.0 0.92 9.4 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain MeaB PF03308.16 AET37442.1 - 0.0022 17.1 0.0 0.2 10.6 0.0 2.6 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 AET37442.1 - 0.0026 18.0 0.4 1.8 8.8 0.0 3.4 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase DUF815 PF05673.13 AET37442.1 - 0.0052 16.0 1.6 2 7.5 0.0 3.3 4 0 0 4 4 3 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 AET37442.1 - 0.0061 16.6 0.1 2.6 8.1 0.2 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) G-alpha PF00503.20 AET37442.1 - 0.0098 15.1 0.2 1.7 7.8 0.0 2.9 2 1 0 3 3 3 1 G-protein alpha subunit IstB_IS21 PF01695.17 AET37442.1 - 0.01 15.6 0.0 0.18 11.5 0.0 2.6 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_7 PF12775.7 AET37442.1 - 0.011 15.2 0.1 0.87 9.1 0.0 2.7 3 0 0 3 3 2 0 P-loop containing dynein motor region NTPase_1 PF03266.15 AET37442.1 - 0.014 15.3 0.1 0.7 9.8 0.1 2.5 2 0 0 2 2 2 0 NTPase AAA_25 PF13481.6 AET37442.1 - 0.016 14.8 0.1 0.8 9.2 0.0 3.1 2 1 0 2 2 2 0 AAA domain VirE PF05272.11 AET37442.1 - 0.024 14.4 0.0 1.8 8.3 0.0 2.9 3 0 0 3 3 3 0 Virulence-associated protein E AAA_30 PF13604.6 AET37442.1 - 0.053 13.2 3.3 0.69 9.6 0.1 3.4 4 1 0 4 4 2 0 AAA domain TsaE PF02367.17 AET37442.1 - 0.075 13.0 5.0 3 7.9 0.0 3.6 3 1 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FeoB_N PF02421.18 AET37442.1 - 0.089 12.3 0.0 3 7.3 0.0 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B MobB PF03205.14 AET37442.1 - 0.1 12.5 0.3 0.84 9.5 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B CLP1_P PF16575.5 AET37442.1 - 0.1 12.4 1.1 10 5.8 0.0 3.6 4 0 0 4 4 4 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_17 PF13207.6 AET37442.1 - 0.1 13.0 1.6 27 5.2 0.0 3.5 3 0 0 3 3 3 0 AAA domain T2SSE PF00437.20 AET37442.1 - 0.11 11.6 0.0 0.63 9.1 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_27 PF13514.6 AET37442.1 - 0.18 11.3 6.9 1 8.9 0.0 3.3 4 0 0 4 4 3 0 AAA domain PduV-EutP PF10662.9 AET37442.1 - 0.21 11.4 1.4 25 4.6 0.0 3.4 4 0 0 4 4 3 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 AET37442.1 - 0.21 11.6 7.1 9.8 6.2 0.0 4.1 4 1 1 5 5 4 0 Dynamin family ATPase_2 PF01637.18 AET37442.1 - 0.42 10.5 3.9 8.3 6.2 0.0 3.0 4 0 0 4 4 3 0 ATPase domain predominantly from Archaea DUF87 PF01935.17 AET37442.1 - 0.96 9.5 9.9 20 5.2 0.0 4.3 4 1 1 5 5 5 0 Helicase HerA, central domain PNRC PF15365.6 AET37443.1 - 0.003 17.3 0.7 0.0087 15.8 0.7 1.9 1 0 0 1 1 1 1 Proline-rich nuclear receptor coactivator motif DUF5364 PF17322.2 AET37444.1 - 1.1e-38 133.5 13.5 5.1e-37 128.0 13.5 2.0 1 1 0 1 1 1 1 Family of unknown function (DUF5364) Peptidase_C10 PF01640.17 AET37444.1 - 0.23 11.7 0.8 0.32 11.3 0.8 1.2 1 0 0 1 1 1 0 Peptidase C10 family NIF3 PF01784.18 AET37445.1 - 1.9e-68 230.7 0.5 2.3e-68 230.5 0.5 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) BolA PF01722.18 AET37446.1 - 4.3e-16 59.0 0.0 4.9e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 BolA-like protein Kinesin PF00225.23 AET37448.1 - 2.2e-113 378.5 0.3 4.2e-113 377.7 0.3 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 AET37448.1 - 2.2e-25 89.4 0.0 5.9e-25 87.9 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding AAA_33 PF13671.6 AET37448.1 - 0.055 13.6 0.1 0.38 10.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain UvrD-helicase PF00580.21 AET37448.1 - 6.1 6.3 12.1 2.1 7.8 6.7 2.3 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain Cyclin_N PF00134.23 AET37449.1 - 0.0003 20.5 0.0 0.00059 19.6 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 AET37449.1 - 0.00069 20.0 0.0 0.0014 19.0 0.0 1.5 1 0 0 1 1 1 1 Cyclin EHN PF06441.12 AET37449.1 - 0.42 11.0 2.4 0.53 10.7 0.3 2.1 2 0 0 2 2 2 0 Epoxide hydrolase N terminus WD40 PF00400.32 AET37450.1 - 1.8e-11 44.4 14.8 0.00029 21.6 0.1 6.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET37450.1 - 5e-10 39.6 0.0 6.3e-06 26.4 0.0 3.1 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AET37450.1 - 0.067 12.1 0.2 2 7.3 0.0 3.0 1 1 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PX PF00787.24 AET37451.1 - 2.3e-10 40.5 0.2 7.7e-10 38.8 0.0 1.9 2 0 0 2 2 2 1 PX domain COMP PF11598.8 AET37451.1 - 0.083 13.4 5.5 0.48 10.9 1.7 2.9 3 0 0 3 3 3 0 Cartilage oligomeric matrix protein Fez1 PF06818.15 AET37451.1 - 0.11 13.0 9.4 0.087 13.3 7.8 1.7 2 0 0 2 2 2 0 Fez1 zn-ribbon_14 PF16503.5 AET37452.1 - 3.8e-17 61.5 4.2 3.8e-17 61.5 4.2 3.4 3 0 0 3 3 3 1 Zinc-ribbon ATP_bind_3 PF01171.20 AET37452.1 - 4.8e-16 59.0 0.0 8.6e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 PP-loop family tRNA_Me_trans PF03054.16 AET37452.1 - 0.052 12.3 0.0 0.098 11.4 0.0 1.4 1 1 0 1 1 1 0 tRNA methyl transferase Ras PF00071.22 AET37454.1 - 2.4e-60 202.8 0.3 2.9e-60 202.5 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET37454.1 - 1e-34 119.3 0.1 1.6e-34 118.7 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET37454.1 - 2.3e-13 50.0 0.0 3.1e-13 49.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AET37454.1 - 4e-07 30.1 0.1 6.5e-07 29.4 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AET37454.1 - 0.0001 21.9 0.1 0.00037 20.1 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AET37454.1 - 0.00066 19.6 0.1 0.01 15.7 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 AET37454.1 - 0.0011 18.4 0.0 0.0014 18.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 AET37454.1 - 0.0031 17.0 0.0 0.0051 16.3 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 AET37454.1 - 0.01 15.4 0.0 0.017 14.6 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.9 AET37454.1 - 0.021 14.6 0.0 0.035 13.8 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 AET37454.1 - 0.026 14.9 0.1 0.049 14.0 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 AET37454.1 - 0.034 14.4 0.1 0.078 13.2 0.1 1.9 1 1 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 AET37454.1 - 0.06 12.6 0.0 0.084 12.1 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain DUF1128 PF06569.11 AET37454.1 - 0.067 13.2 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1128) Septin PF00735.18 AET37454.1 - 0.071 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_24 PF13479.6 AET37454.1 - 0.088 12.5 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AET37454.1 - 0.09 13.3 0.5 0.14 12.7 0.5 1.6 1 1 0 1 1 1 0 ABC transporter AAA_21 PF13304.6 AET37454.1 - 0.13 12.0 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system CHZ PF09649.10 AET37455.1 - 3.6e-18 64.7 2.7 3.6e-18 64.7 2.7 3.6 4 0 0 4 4 4 1 Histone chaperone domain CHZ ORC6 PF05460.13 AET37455.1 - 0.06 12.6 2.4 0.07 12.4 2.4 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DNA_pol_phi PF04931.13 AET37455.1 - 9.2 4.2 25.1 11 3.9 25.1 1.0 1 0 0 1 1 1 0 DNA polymerase phi LSM PF01423.22 AET37456.1 - 3.9e-18 64.9 0.0 5.9e-18 64.3 0.0 1.3 1 0 0 1 1 1 1 LSM domain DUF3138 PF11336.8 AET37456.1 - 0.42 9.2 3.0 0.53 8.8 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) AMPK1_CBM PF16561.5 AET37457.1 - 7.7e-30 103.0 0.0 1.5e-29 102.0 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 AET37457.1 - 5.7e-27 93.8 2.0 1e-26 92.9 2.0 1.5 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain CBM53 PF16760.5 AET37457.1 - 0.15 12.7 0.0 0.38 11.4 0.0 1.7 1 0 0 1 1 1 0 Starch/carbohydrate-binding module (family 53) SPT16 PF08644.11 AET37458.1 - 1.5e-50 171.3 0.2 1.5e-50 171.3 0.2 2.1 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 AET37458.1 - 3.6e-50 169.9 2.2 9.5e-50 168.5 0.1 2.5 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 AET37458.1 - 1.4e-30 106.6 0.0 2.3e-30 105.8 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 AET37458.1 - 2.9e-13 50.0 0.1 3e-12 46.8 0.1 2.7 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Clathrin PF00637.20 AET37459.1 - 2.3e-187 614.4 50.1 4e-34 117.5 0.1 7.7 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 AET37459.1 - 3.1e-27 94.3 4.1 9.3e-27 92.7 0.4 3.2 3 0 0 3 3 3 1 Clathrin-H-link Clathrin_propel PF01394.20 AET37459.1 - 1.5e-19 69.3 4.5 0.00011 22.3 0.3 5.9 5 0 0 5 5 5 5 Clathrin propeller repeat Clathrin-link PF09268.10 AET37459.1 - 6.5e-09 35.0 2.9 1.3e-08 34.1 0.7 2.5 2 0 0 2 2 2 1 Clathrin, heavy-chain linker Vps39_1 PF10366.9 AET37459.1 - 0.011 16.0 16.4 0.25 11.6 0.3 7.2 9 0 0 9 9 9 0 Vacuolar sorting protein 39 domain 1 TPR_7 PF13176.6 AET37459.1 - 0.02 14.9 5.7 26 5.2 0.0 7.1 9 0 0 9 9 9 0 Tetratricopeptide repeat PPR PF01535.20 AET37459.1 - 0.25 11.7 4.5 35 4.9 0.1 4.7 3 1 1 4 4 4 0 PPR repeat TPR_8 PF13181.6 AET37459.1 - 0.28 11.5 8.6 2.9 8.3 0.0 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.28 AET37459.1 - 0.33 10.9 10.2 77 3.4 0.0 6.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_12 PF13424.6 AET37459.1 - 9.9 6.5 8.3 13 6.2 0.1 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat ACOX PF01756.19 AET37461.1 - 2.4e-43 147.8 0.0 4.1e-43 147.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 AET37461.1 - 1.9e-20 72.8 0.1 3.4e-20 72.1 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 AET37461.1 - 1.6e-09 38.3 0.0 3.7e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 AET37461.1 - 4.7e-05 23.6 0.0 0.00066 19.9 0.0 2.3 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain CLAMP PF14769.6 AET37461.1 - 0.15 12.6 0.6 11 6.5 0.0 2.6 2 0 0 2 2 2 0 Flagellar C1a complex subunit C1a-32 CDP-OH_P_transf PF01066.21 AET37462.1 - 8.6e-11 42.5 0.7 8.6e-11 42.5 0.7 1.8 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase GEP5 PF17053.5 AET37463.1 - 0.0063 16.4 2.3 0.0093 15.8 2.3 1.1 1 0 0 1 1 1 1 Genetic interactor of prohibitin 5 TetR_C_26 PF17934.1 AET37463.1 - 0.0087 16.4 0.3 0.015 15.6 0.3 1.5 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain Peptidase_S10 PF00450.22 AET37464.1 - 1.1e-105 354.5 0.0 1.3e-105 354.2 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Phosphorylase PF00343.20 AET37465.1 - 0 1015.7 0.0 0 1015.2 0.0 1.2 1 0 0 1 1 1 1 Carbohydrate phosphorylase MCM PF00493.23 AET37466.1 - 6.5e-104 345.9 0.5 9.8e-104 345.3 0.5 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AET37466.1 - 8.9e-39 132.2 0.1 1.8e-38 131.3 0.1 1.5 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 AET37466.1 - 1.5e-28 99.2 1.0 1.5e-28 99.2 1.0 2.0 2 0 0 2 2 2 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 AET37466.1 - 1.1e-26 93.1 2.4 2.6e-26 91.8 2.4 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 AET37466.1 - 8.9e-23 80.9 0.7 3.3e-22 79.0 0.7 2.1 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 AET37466.1 - 4.8e-07 29.4 0.0 1.6e-06 27.7 0.0 1.8 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI GIDA_assoc PF13932.6 AET37466.1 - 0.00026 21.3 0.8 0.00026 21.3 0.8 1.8 2 0 0 2 2 2 1 GidA associated domain Sigma54_activat PF00158.26 AET37466.1 - 0.0042 16.8 0.0 0.0084 15.8 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 AET37466.1 - 0.0048 16.8 0.0 0.013 15.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AET37466.1 - 0.016 15.2 0.0 0.071 13.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RE_SacI PF09566.10 AET37466.1 - 0.12 12.2 1.7 0.5 10.1 0.0 2.6 3 0 0 3 3 3 0 SacI restriction endonuclease Arc_PepC PF06819.11 AET37466.1 - 0.79 9.9 5.4 16 5.6 0.1 3.0 3 0 0 3 3 2 0 Archaeal Peptidase A24 C-terminal Domain SKN1 PF03935.15 AET37467.1 - 5.1e-254 843.3 4.1 5.9e-254 843.0 4.1 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) SIS PF01380.22 AET37468.1 - 2.7e-16 59.6 0.1 4.3e-16 58.9 0.1 1.3 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.6 AET37468.1 - 0.00026 21.0 0.3 0.32 11.0 0.0 2.6 1 1 1 2 2 2 2 SIS domain Tir_receptor_C PF07489.11 AET37468.1 - 0.07 13.1 1.4 0.12 12.3 1.4 1.3 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Inj_translocase PF16928.5 AET37468.1 - 0.18 11.3 0.0 0.26 10.7 0.0 1.2 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome ABC2_membrane PF01061.24 AET37469.1 - 2.5e-47 161.0 56.7 1.4e-25 90.0 23.9 2.9 4 0 0 4 4 3 2 ABC-2 type transporter PDR_CDR PF06422.12 AET37469.1 - 9.5e-24 83.1 5.2 9.7e-16 57.5 0.0 3.0 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.27 AET37469.1 - 3.3e-12 47.1 0.1 1.8e-11 44.7 0.0 2.2 3 0 0 3 3 3 1 ABC transporter AAA_21 PF13304.6 AET37469.1 - 7.6e-06 25.9 1.4 0.058 13.2 0.9 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 AET37469.1 - 0.0001 21.6 17.7 0.0001 21.6 17.7 3.2 3 0 0 3 3 3 1 ABC-2 family transporter protein AAA_23 PF13476.6 AET37469.1 - 0.00014 22.4 0.2 0.00027 21.5 0.2 1.4 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 AET37469.1 - 0.0011 18.9 0.1 0.0021 18.0 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 AET37469.1 - 0.0014 18.1 0.0 0.014 14.8 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 AET37469.1 - 0.015 15.0 0.9 0.035 13.8 0.3 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_22 PF13401.6 AET37469.1 - 0.026 14.8 0.2 0.078 13.2 0.2 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 AET37469.1 - 0.075 13.4 0.1 0.22 11.9 0.1 1.7 1 0 0 1 1 1 0 AAA ATPase domain SRP1_TIP1 PF00660.17 AET37470.1 - 3.6e-28 97.5 0.1 5.5e-28 96.9 0.1 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family CAP_N PF01213.19 AET37470.1 - 0.16 11.4 1.6 0.24 10.9 1.6 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal BASP1 PF05466.12 AET37470.1 - 0.99 9.4 13.8 1.4 8.9 13.8 1.2 1 0 0 1 1 1 0 Brain acid soluble protein 1 (BASP1 protein) Vps62 PF06101.11 AET37472.1 - 5.5e-05 21.7 5.2 9.4e-05 20.9 5.2 1.5 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 NDC10_II PF16787.5 AET37473.1 - 5.3e-58 196.6 9.4 5.3e-58 196.6 9.4 2.7 2 1 0 2 2 2 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GCR1_C PF12550.8 AET37473.1 - 1.2e-17 64.0 1.7 1.3e-17 63.9 0.2 1.9 2 0 0 2 2 2 1 Transcriptional activator of glycolytic enzymes CENP-Q PF13094.6 AET37473.1 - 3.8 7.7 13.6 3.8 7.7 11.0 2.2 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit NCA2 PF08637.10 AET37474.1 - 1.6e-94 316.3 1.6 2.3e-94 315.8 1.6 1.2 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 DUF1829 PF08862.10 AET37474.1 - 0.1 13.1 0.0 0.21 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF1829 SH3_1 PF00018.28 AET37475.1 - 7.7e-15 54.2 0.0 1.2e-14 53.6 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AET37475.1 - 5.5e-13 48.6 0.0 9.4e-13 47.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AET37475.1 - 6.8e-11 41.7 0.0 1.1e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain zf-C4H2 PF10146.9 AET37475.1 - 0.073 13.4 0.0 0.12 12.6 0.0 1.3 1 1 0 1 1 1 0 Zinc finger-containing protein Proteasome PF00227.26 AET37476.1 - 3.6e-58 196.2 0.3 4.5e-58 195.9 0.3 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AET37476.1 - 4.2e-12 45.5 0.9 8.1e-12 44.6 0.2 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature FF PF01846.19 AET37477.1 - 2.1e-10 40.6 2.1 2.1e-10 40.6 2.1 2.6 2 1 1 3 3 3 1 FF domain WW PF00397.26 AET37477.1 - 0.00013 22.0 2.8 0.00031 20.8 2.8 1.7 1 0 0 1 1 1 1 WW domain CENP-B_dimeris PF09026.10 AET37477.1 - 0.0018 18.6 12.0 0.36 11.3 6.1 2.4 2 0 0 2 2 2 2 Centromere protein B dimerisation domain FAM176 PF14851.6 AET37477.1 - 0.051 13.2 7.1 0.85 9.3 0.8 2.4 2 0 0 2 2 2 0 FAM176 family BLOC1S3 PF15753.5 AET37477.1 - 0.28 11.3 12.0 2.2 8.4 3.4 2.5 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 DUF3682 PF12446.8 AET37477.1 - 1.5 9.3 18.4 0.96 9.9 8.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) RXT2_N PF08595.11 AET37477.1 - 2.7 8.0 11.0 0.62 10.1 1.2 2.7 2 1 1 3 3 3 0 RXT2-like, N-terminal Vps39_1 PF10366.9 AET37477.1 - 3.9 7.8 7.3 0.65 10.3 1.9 2.4 2 1 1 3 3 3 0 Vacuolar sorting protein 39 domain 1 E7 PF00527.18 AET37477.1 - 4.8 7.5 11.4 2.5 8.3 1.8 3.1 3 0 0 3 3 3 0 E7 protein, Early protein Pet20 PF08692.10 AET37479.1 - 4.9e-16 59.6 0.0 5.2e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial protein Pet20 UQ_con PF00179.26 AET37480.1 - 5.5e-37 126.5 0.0 6.2e-37 126.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.11 AET37480.1 - 0.018 14.7 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 UEV PF05743.13 AET37480.1 - 0.033 14.1 0.1 0.052 13.4 0.1 1.3 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 AET37480.1 - 0.26 11.6 1.9 0.38 11.0 1.8 1.4 1 1 0 1 1 1 0 RWD domain Band_7 PF01145.25 AET37481.1 - 6.2e-23 81.7 5.5 1.1e-22 80.9 5.5 1.4 1 1 0 1 1 1 1 SPFH domain / Band 7 family Peptidase_S66 PF02016.15 AET37481.1 - 0.0018 18.4 0.4 0.0047 17.0 0.0 2.0 2 0 0 2 2 2 1 LD-carboxypeptidase N-terminal domain MARVEL PF01284.23 AET37482.1 - 1.5e-27 96.4 11.1 1.9e-27 96.0 11.1 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF2244 PF10003.9 AET37482.1 - 8.3 6.1 7.9 2.7 7.7 3.2 2.2 1 1 1 2 2 2 0 Integral membrane protein (DUF2244) FAM184 PF15665.5 AET37483.1 - 0.88 9.3 42.7 0.17 11.6 21.4 2.6 2 1 1 3 3 3 0 Family with sequence similarity 184, A and B Vac_Fusion PF02346.16 AET37483.1 - 2.6 7.8 4.7 4.6 7.0 0.1 3.0 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 DASH_Dam1 PF08653.10 AET37483.1 - 3.1 7.7 4.7 16 5.4 0.7 3.1 3 1 0 3 3 3 0 DASH complex subunit Dam1 Spc7 PF08317.11 AET37483.1 - 3.3 6.5 46.4 1.7 7.5 22.3 3.4 1 1 2 3 3 3 0 Spc7 kinetochore protein BAR_2 PF10455.9 AET37484.1 - 5.7e-95 317.8 12.4 5.7e-95 317.8 12.4 1.4 2 0 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 AET37484.1 - 3.8e-08 33.3 17.7 9.2e-06 25.5 13.2 3.9 2 2 1 3 3 3 2 BAR domain Med27 PF11571.8 AET37484.1 - 0.46 10.9 2.3 0.79 10.1 0.1 2.4 2 1 0 2 2 2 0 Mediator complex subunit 27 HIP1_clath_bdg PF16515.5 AET37484.1 - 0.55 10.9 11.9 2.2 8.9 4.9 3.0 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 SYF2 PF08231.12 AET37485.1 - 1.2e-11 45.2 10.4 1.1e-10 42.2 10.4 2.1 1 1 0 1 1 1 1 SYF2 splicing factor DUF3907 PF13047.6 AET37485.1 - 0.053 13.5 0.1 0.097 12.6 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3907) DUF2252 PF10009.9 AET37485.1 - 0.091 11.8 1.0 0.14 11.2 0.5 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) DUF4208 PF13907.6 AET37485.1 - 0.11 12.9 2.6 7.8 7.0 0.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4208) CART PF06373.11 AET37485.1 - 0.46 10.7 2.6 1.3 9.3 0.6 2.2 2 0 0 2 2 2 0 Cocaine and amphetamine regulated transcript protein (CART) LIDHydrolase PF10230.9 AET37486.1 - 2e-67 227.6 0.0 2.3e-67 227.4 0.0 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 AET37486.1 - 3.8e-05 23.1 0.0 5.1e-05 22.7 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AET37486.1 - 0.00021 21.1 0.0 0.0004 20.1 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 AET37486.1 - 0.14 12.0 0.0 0.72 9.7 0.0 1.9 2 0 0 2 2 2 0 Serine hydrolase TANGO2 PF05742.12 AET37487.1 - 7.8e-57 193.2 0.0 9.1e-57 193.0 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 Asn_synthase PF00733.21 AET37488.1 - 1.1e-94 318.1 0.4 9e-54 183.5 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 AET37488.1 - 5.1e-33 113.6 0.0 8.8e-33 112.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 AET37488.1 - 3.6e-25 88.7 0.0 9e-25 87.4 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.8 AET37488.1 - 0.00055 19.5 0.0 0.0011 18.4 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 AET37488.1 - 0.008 15.3 0.0 0.015 14.5 0.0 1.5 1 1 0 1 1 1 1 NAD synthase CBF PF03914.17 AET37489.1 - 2e-35 122.3 0.7 3.6e-35 121.5 0.7 1.4 1 0 0 1 1 1 1 CBF/Mak21 family CDP-OH_P_transf PF01066.21 AET37490.1 - 1.4e-13 51.4 0.1 1.4e-13 51.4 0.1 2.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF2838 PF10998.8 AET37490.1 - 8.4 6.7 11.7 2.3 8.5 0.1 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF2838) Mito_carr PF00153.27 AET37491.1 - 3.8e-57 190.2 3.5 3.4e-22 78.2 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Cyt_c_ox_IV PF12270.8 AET37491.1 - 0.071 13.3 0.1 0.93 9.6 0.1 2.3 1 1 1 2 2 2 0 Cytochrome c oxidase subunit IV RNase_PH PF01138.21 AET37492.1 - 6.2e-14 52.6 0.0 2.7e-13 50.5 0.0 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AET37492.1 - 0.0087 16.1 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 KH_9 PF17904.1 AET37492.1 - 0.058 13.8 0.0 0.092 13.1 0.0 1.4 1 0 0 1 1 1 0 FMRP KH0 domain TetR_C_24 PF17932.1 AET37492.1 - 0.099 12.9 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain tRNA-synt_1 PF00133.22 AET37493.1 - 1.2e-232 773.5 0.0 1.2e-232 773.5 0.0 2.5 2 1 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AET37493.1 - 1.9e-30 105.9 0.5 1.9e-30 105.9 0.5 2.5 3 0 0 3 3 3 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 AET37493.1 - 4.3e-14 52.1 5.6 3.3e-08 32.7 0.0 4.6 5 1 0 5 5 5 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 AET37493.1 - 3.7e-10 39.6 6.1 1.1e-06 28.3 0.0 3.4 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.9 AET37493.1 - 3.3e-05 24.1 5.6 3.3e-05 24.1 5.6 2.8 2 0 0 2 2 2 1 Valyl tRNA synthetase tRNA binding arm Lzipper-MIP1 PF14389.6 AET37493.1 - 0.0001 22.5 3.6 0.00025 21.3 3.6 1.6 1 0 0 1 1 1 1 Leucine-zipper of ternary complex factor MIP1 AAA_23 PF13476.6 AET37493.1 - 0.1 13.1 12.2 0.4 11.2 0.4 2.6 2 0 0 2 2 2 0 AAA domain tRNA-synt_1e PF01406.19 AET37493.1 - 0.11 11.8 7.0 0.35 10.2 0.0 3.4 4 1 0 4 4 4 0 tRNA synthetases class I (C) catalytic domain AAA_11 PF13086.6 AET37493.1 - 1 9.1 10.7 0.16 11.7 4.0 2.2 2 0 0 2 2 2 0 AAA domain DASH_Spc19 PF08287.11 AET37493.1 - 2.4 8.0 15.4 4.9 7.0 2.9 2.5 2 0 0 2 2 2 0 Spc19 LETM1 PF07766.13 AET37494.1 - 3.9e-97 324.8 4.1 3.9e-97 324.8 4.1 1.5 2 0 0 2 2 2 1 LETM1-like protein Ctr PF04145.15 AET37495.1 - 5.6e-20 72.5 0.2 1.3e-19 71.3 0.2 1.6 1 0 0 1 1 1 1 Ctr copper transporter family DUF4229 PF14012.6 AET37495.1 - 0.036 14.2 8.3 0.079 13.1 8.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4229) DASH_Dam1 PF08653.10 AET37496.1 - 1.5e-25 88.7 2.5 1.6e-25 88.7 0.5 1.9 2 0 0 2 2 2 1 DASH complex subunit Dam1 SURF1 PF02104.15 AET37497.1 - 2.3e-41 142.0 0.1 3.4e-41 141.4 0.1 1.2 1 0 0 1 1 1 1 SURF1 family Ribosomal_S5_C PF03719.15 AET37498.1 - 2.7e-24 84.4 0.0 5.1e-24 83.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 AET37498.1 - 5.5e-23 80.7 0.0 1.2e-22 79.7 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain HMG_box PF00505.19 AET37499.1 - 1.6e-11 44.5 6.2 1.6e-11 44.5 6.2 2.8 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 AET37499.1 - 6.7e-06 26.6 1.1 6.7e-06 26.6 1.1 2.0 2 0 0 2 2 2 1 HMG-box domain Enkurin PF13864.6 AET37499.1 - 0.15 12.5 7.6 0.4 11.2 1.0 2.7 2 0 0 2 2 2 0 Calmodulin-binding Peptidase_M41 PF01434.18 AET37500.1 - 1.6e-65 220.5 0.0 2.3e-65 220.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 AET37500.1 - 2.7e-41 141.1 0.0 8.3e-41 139.5 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AET37500.1 - 1.3e-13 50.5 0.1 4.7e-13 48.7 0.2 2.0 2 0 0 2 2 2 1 AAA+ lid domain FtsH_ext PF06480.15 AET37500.1 - 1.5e-09 38.1 0.0 3.3e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 FtsH Extracellular AAA_16 PF13191.6 AET37500.1 - 0.012 16.0 0.7 0.054 13.9 0.2 2.4 2 1 0 2 2 2 0 AAA ATPase domain TIP49 PF06068.13 AET37500.1 - 0.017 14.3 0.1 0.035 13.3 0.1 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain CARD PF00619.21 AET37500.1 - 0.029 14.4 0.1 0.059 13.4 0.1 1.5 1 0 0 1 1 1 0 Caspase recruitment domain AAA_5 PF07728.14 AET37500.1 - 0.041 13.9 0.1 0.16 12.0 0.1 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AET37500.1 - 0.072 13.4 0.3 2.1 8.6 0.1 2.7 3 0 0 3 3 3 0 AAA domain AAA_17 PF13207.6 AET37500.1 - 0.075 13.5 0.0 0.23 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 AET37500.1 - 0.089 12.5 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 AET37500.1 - 0.099 12.9 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain EB1 PF03271.17 AET37501.1 - 9.3e-16 57.8 0.3 1.7e-15 56.9 0.3 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 AET37501.1 - 4.5e-06 26.8 0.2 8.3e-06 25.9 0.2 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain CH_2 PF06294.11 AET37501.1 - 0.077 13.1 0.1 0.15 12.2 0.1 1.6 1 0 0 1 1 1 0 CH-like domain in sperm protein TolA_bind_tri PF16331.5 AET37501.1 - 0.082 13.0 0.4 0.28 11.3 0.1 2.0 2 0 0 2 2 2 0 TolA binding protein trimerisation CENP-Q PF13094.6 AET37501.1 - 0.13 12.4 0.0 0.23 11.7 0.0 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit GCR1_C PF12550.8 AET37502.1 - 1.8e-14 53.8 3.1 4.5e-14 52.5 3.1 1.7 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Viral_P18 PF04521.13 AET37502.1 - 0.00021 21.1 0.0 0.14 11.9 0.0 3.2 3 0 0 3 3 3 1 ssRNA positive strand viral 18kD cysteine rich protein Peptidase_M99_m PF17130.4 AET37502.1 - 0.078 12.9 0.2 0.21 11.5 0.2 1.7 1 0 0 1 1 1 0 beta-barrel domain of carboxypeptidase M99 SlyX PF04102.12 AET37502.1 - 0.81 10.3 3.5 7 7.4 3.5 2.7 1 1 0 1 1 1 0 SlyX SbsC_C PF18058.1 AET37502.1 - 4.1 7.7 8.7 0.51 10.6 0.5 3.0 4 0 0 4 4 4 0 SbsC C-terminal domain RRM_5 PF13893.6 AET37503.1 - 1.6e-08 34.2 0.0 1.8e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 AET37503.1 - 1.8e-08 34.1 0.1 3.6e-08 33.1 0.1 1.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ubiquitin_2 PF14560.6 AET37503.1 - 0.02 15.3 0.1 0.027 14.9 0.1 1.2 1 0 0 1 1 1 0 Ubiquitin-like domain Amino_oxidase PF01593.24 AET37504.1 - 4.5e-18 65.8 0.0 5.1e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 AET37504.1 - 5.7e-08 32.9 0.0 1.4e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 AET37504.1 - 1.5e-05 24.7 0.0 4.3e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 AET37504.1 - 0.00046 20.7 0.1 0.049 14.2 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 AET37504.1 - 0.00085 18.6 0.0 0.0015 17.8 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 AET37504.1 - 0.002 17.4 0.0 0.0068 15.7 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.15 AET37504.1 - 0.0023 16.6 0.0 0.089 11.3 0.0 2.3 2 0 0 2 2 2 1 Malate:quinone oxidoreductase (Mqo) NAD_binding_9 PF13454.6 AET37504.1 - 0.026 14.5 0.0 0.67 9.9 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 AET37504.1 - 0.028 13.7 0.0 0.21 10.9 0.0 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 AET37504.1 - 0.11 11.5 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein HA2 PF04408.23 AET37505.1 - 1.6e-24 86.3 0.0 6.4e-24 84.3 0.0 2.1 2 0 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 AET37505.1 - 5.3e-18 65.2 0.0 1.6e-17 63.6 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 AET37505.1 - 4.4e-14 52.8 0.0 1.6e-13 51.0 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.23 AET37505.1 - 2.3e-10 40.7 0.0 5.5e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 S1 RNA binding domain DEAD PF00270.29 AET37505.1 - 7.4e-06 25.8 0.2 1.9e-05 24.5 0.2 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AET37505.1 - 3.7e-05 24.0 0.1 0.00014 22.1 0.1 2.0 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 AET37505.1 - 0.00041 19.5 0.0 0.0049 16.0 0.0 2.5 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_30 PF13604.6 AET37505.1 - 0.00064 19.5 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AET37505.1 - 0.0022 18.4 0.1 0.0053 17.1 0.1 1.7 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 AET37505.1 - 0.0033 17.9 4.6 1.3 9.5 0.1 3.5 2 1 0 3 3 3 2 ABC transporter PWI PF01480.17 AET37505.1 - 0.0056 17.0 0.8 0.24 11.7 0.2 2.8 2 0 0 2 2 2 1 PWI domain AAA_14 PF13173.6 AET37505.1 - 0.024 14.7 0.1 0.37 10.8 0.1 2.8 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 AET37505.1 - 0.034 13.8 0.1 0.094 12.3 0.1 1.8 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain EF-hand_14 PF17959.1 AET37505.1 - 0.14 12.5 1.9 0.91 9.9 0.1 2.9 2 1 0 2 2 2 0 EF-hand domain AAA_23 PF13476.6 AET37505.1 - 0.62 10.5 0.0 0.62 10.5 0.0 3.7 4 0 0 4 4 4 0 AAA domain Proteasome PF00227.26 AET37506.1 - 2.1e-40 138.3 0.0 2.3e-40 138.1 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit MucBP_2 PF17965.1 AET37506.1 - 0.12 13.0 0.4 0.22 12.1 0.0 1.6 2 0 0 2 2 2 0 Mucin binding domain DNA_primase_S PF01896.19 AET37507.1 - 1e-66 224.3 2.0 1.4e-66 223.9 2.0 1.2 1 0 0 1 1 1 1 DNA primase small subunit Glyco_hydro_5_C PF18564.1 AET37508.1 - 2.2e-13 50.6 0.0 4.8e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 AET37508.1 - 2.4e-10 40.3 2.8 3.8e-05 23.3 1.1 2.7 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) LETM1 PF07766.13 AET37509.1 - 4.4e-99 331.2 6.8 4.4e-99 331.2 6.8 1.6 2 0 0 2 2 2 1 LETM1-like protein TAL_effector PF03377.13 AET37509.1 - 0.2 12.0 0.0 15 6.0 0.1 2.4 2 0 0 2 2 2 0 TAL effector repeat Rpr2 PF04032.16 AET37511.1 - 9.6e-19 67.5 2.3 1.3e-18 67.0 2.3 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain TOM13 PF08219.11 AET37512.1 - 1.2e-22 79.6 0.0 2.3e-22 78.8 0.0 1.5 1 0 0 1 1 1 1 Outer membrane protein TOM13 Proteasome PF00227.26 AET37513.1 - 7e-57 192.0 0.0 9e-57 191.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AET37513.1 - 1.2e-12 47.3 0.2 4.2e-12 45.5 0.0 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature ANAPC_CDC26 PF10471.9 AET37513.1 - 0.74 10.7 3.9 1.5 9.7 3.9 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 RNA_pol_Rpb1_3 PF04983.18 AET37514.1 - 0.0061 16.5 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 bZIP_2 PF07716.15 AET37515.1 - 1.9e-05 24.6 14.6 0.00012 22.0 11.8 2.9 1 1 1 2 2 2 2 Basic region leucine zipper bZIP_1 PF00170.21 AET37515.1 - 0.16 12.1 14.7 0.16 12.1 11.6 2.4 2 0 0 2 2 2 0 bZIP transcription factor Pkinase PF00069.25 AET37516.1 - 3e-72 243.2 0.0 5.6e-72 242.3 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET37516.1 - 2.2e-42 145.1 0.0 3e-42 144.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET37516.1 - 0.00074 18.9 1.0 0.0054 16.1 0.0 2.5 2 1 1 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 AET37516.1 - 0.00087 18.2 1.9 0.0018 17.2 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 AET37516.1 - 0.0097 15.3 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Glycogen_syn PF05693.13 AET37517.1 - 0 1102.0 0.0 0 1101.8 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 AET37517.1 - 6.5e-09 35.5 0.0 4e-06 26.5 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AET37517.1 - 1.6e-06 28.6 0.0 0.0032 17.9 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 AET37517.1 - 6.4e-05 23.4 0.2 0.00016 22.1 0.2 1.7 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 AET37517.1 - 0.00013 22.0 0.7 0.00054 20.0 0.3 2.0 1 1 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_transf_5 PF08323.11 AET37517.1 - 0.00018 21.3 0.1 0.00039 20.2 0.1 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain Phage_hub_GP28 PF11110.8 AET37517.1 - 0.13 12.1 0.0 2.7 7.9 0.0 2.3 2 0 0 2 2 2 0 Baseplate hub distal subunit SH3BGR PF04908.15 AET37519.1 - 0.0016 18.6 0.0 0.0065 16.6 0.0 2.1 2 0 0 2 2 2 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 AET37519.1 - 0.02 15.1 0.0 0.075 13.3 0.0 2.0 1 0 0 1 1 1 0 Glutaredoxin PYST-C1 PF09690.10 AET37519.1 - 0.8 9.5 5.2 3.7 7.4 2.4 2.6 2 0 0 2 2 2 0 Plasmodium yoelii subtelomeric region (PYST-C1) Citrate_synt PF00285.21 AET37520.1 - 2.1e-100 336.3 0.0 2.5e-100 336.1 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Cupin_8 PF13621.6 AET37521.1 - 7e-12 45.6 0.3 1.5e-11 44.5 0.3 1.5 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 AET37521.1 - 2.4e-11 44.0 0.1 9.5e-11 42.1 0.1 2.1 1 0 0 1 1 1 1 JmjC domain, hydroxylase Elongin_A PF06881.11 AET37521.1 - 0.00029 21.3 0.5 0.00088 19.8 0.5 1.8 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box-like PF12937.7 AET37521.1 - 0.0014 18.4 0.0 0.0014 18.4 0.0 2.4 3 0 0 3 3 3 1 F-box-like Cupin_2 PF07883.11 AET37521.1 - 0.02 14.6 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 Cupin domain Ribosomal_L32p PF01783.23 AET37522.1 - 2.7e-13 49.9 6.9 4.3e-13 49.3 6.9 1.3 1 0 0 1 1 1 1 Ribosomal L32p protein family RecR PF02132.15 AET37522.1 - 0.0064 16.0 0.7 0.012 15.2 0.7 1.4 1 0 0 1 1 1 1 RecR protein zf-ribbon_3 PF13248.6 AET37522.1 - 0.01 15.2 2.2 0.01 15.2 2.2 1.6 2 0 0 2 2 2 0 zinc-ribbon domain Symplekin_C PF12295.8 AET37522.1 - 0.14 12.3 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Symplekin tight junction protein C terminal Septin PF00735.18 AET37523.1 - 6.7e-105 350.4 1.9 7.9e-105 350.2 1.9 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 AET37523.1 - 2.3e-10 40.5 0.1 3.9e-10 39.8 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AET37523.1 - 6.1e-08 32.4 0.8 7.2e-06 25.7 0.3 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 AET37523.1 - 1.6e-06 27.7 0.6 4.9e-06 26.0 0.5 1.9 1 1 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 AET37523.1 - 3.7e-06 26.9 0.3 1.5e-05 25.0 0.1 2.0 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 AET37523.1 - 2.6e-05 24.3 1.8 0.032 14.3 0.4 2.4 1 1 1 2 2 2 2 Dynamin family AAA_16 PF13191.6 AET37523.1 - 0.0011 19.4 0.1 0.0017 18.8 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AET37523.1 - 0.0029 17.9 0.1 0.0071 16.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 AET37523.1 - 0.0037 17.8 1.2 0.0085 16.6 0.8 1.8 1 1 0 1 1 1 1 ABC transporter NB-ARC PF00931.22 AET37523.1 - 0.0057 15.9 0.2 0.01 15.0 0.2 1.5 1 1 0 1 1 1 1 NB-ARC domain AAA_33 PF13671.6 AET37523.1 - 0.0072 16.5 0.5 0.078 13.1 0.8 2.6 2 1 0 2 2 2 1 AAA domain IIGP PF05049.13 AET37523.1 - 0.015 14.4 0.0 0.023 13.8 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_29 PF13555.6 AET37523.1 - 0.017 14.9 0.0 0.041 13.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 AET37523.1 - 0.02 14.3 0.1 0.036 13.4 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_7 PF12775.7 AET37523.1 - 0.028 13.9 0.2 0.073 12.6 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region Roc PF08477.13 AET37523.1 - 0.031 14.5 0.0 0.066 13.4 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 AET37523.1 - 0.041 13.6 1.0 0.22 11.2 1.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AET37523.1 - 0.063 12.8 0.0 0.11 12.0 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 AET37523.1 - 0.069 13.2 0.1 0.22 11.6 0.1 1.9 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 AET37523.1 - 0.092 12.5 0.2 1.1 9.0 0.1 2.6 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 AET37523.1 - 0.094 13.1 0.0 0.24 11.8 0.0 1.7 2 0 0 2 2 1 0 RNA helicase eRF1_3 PF03465.15 AET37524.1 - 9.5e-27 93.7 0.1 2.8e-25 89.0 0.0 2.4 2 0 0 2 2 2 1 eRF1 domain 3 eRF1_2 PF03464.15 AET37524.1 - 3.1e-26 92.3 0.1 4.8e-26 91.6 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_1 PF03463.15 AET37524.1 - 1.3e-23 83.4 0.0 2.1e-23 82.7 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 Rer1 PF03248.13 AET37525.1 - 8.1e-75 250.3 8.8 9.4e-75 250.1 8.8 1.0 1 0 0 1 1 1 1 Rer1 family DUF2208 PF09973.9 AET37525.1 - 0.042 13.5 1.0 0.042 13.5 1.0 2.2 2 1 0 2 2 2 0 Predicted membrane protein (DUF2208) DUF1980 PF09323.10 AET37525.1 - 0.052 13.5 0.7 0.67 9.9 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) PLDc_2 PF13091.6 AET37526.1 - 9.2e-15 54.7 0.0 3e-06 27.1 0.0 2.6 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.22 AET37526.1 - 1.1e-12 47.6 0.5 3.3e-07 30.2 0.0 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif ATP_synt_H PF05493.13 AET37528.1 - 8.8e-20 70.9 4.9 1.1e-19 70.7 4.9 1.1 1 0 0 1 1 1 1 ATP synthase subunit H MFS_2 PF13347.6 AET37528.1 - 0.003 16.2 0.9 0.0032 16.1 0.9 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein Rhomboid PF01694.22 AET37528.1 - 0.02 14.9 0.6 0.023 14.7 0.6 1.0 1 0 0 1 1 1 0 Rhomboid family 7TM-7TMR_HD PF07698.11 AET37528.1 - 0.023 14.5 2.8 0.026 14.3 2.8 1.0 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase AzlD PF05437.12 AET37528.1 - 0.039 14.1 3.6 0.05 13.8 0.1 2.1 1 1 1 2 2 2 0 Branched-chain amino acid transport protein (AzlD) FixQ PF05545.11 AET37528.1 - 0.17 11.9 0.4 0.17 11.9 0.4 1.7 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ Na_H_antiport_1 PF06965.12 AET37528.1 - 0.68 8.7 5.1 0.73 8.6 5.1 1.0 1 0 0 1 1 1 0 Na+/H+ antiporter 1 Vps23_core PF09454.10 AET37529.1 - 5.5e-24 83.9 0.3 9.2e-24 83.2 0.3 1.4 1 0 0 1 1 1 1 Vps23 core domain UEV PF05743.13 AET37529.1 - 2.8e-23 82.1 0.1 1.5e-22 79.7 0.0 2.1 2 0 0 2 2 2 1 UEV domain CortBP2 PF09727.9 AET37529.1 - 0.0053 16.7 0.9 0.0089 15.9 0.9 1.3 1 0 0 1 1 1 1 Cortactin-binding protein-2 CCDC24 PF15669.5 AET37529.1 - 2.9 7.7 5.6 0.42 10.5 0.2 2.3 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 24 family DKCLD PF08068.12 AET37530.1 - 2.8e-32 110.6 0.3 3e-31 107.3 0.5 2.3 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 AET37530.1 - 1.4e-22 79.5 0.3 3.2e-22 78.4 0.3 1.6 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB_N PF01509.18 AET37530.1 - 3.2e-22 79.5 1.3 1.8e-19 70.6 0.0 3.6 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 AET37530.1 - 1.8e-20 72.6 1.5 4.3e-20 71.5 1.4 1.7 2 0 0 2 2 2 1 PUA domain UPF0113 PF03657.13 AET37530.1 - 0.02 15.1 0.0 0.049 13.9 0.0 1.6 1 0 0 1 1 1 0 UPF0113 PUA domain DUF4139 PF13598.6 AET37530.1 - 0.037 13.8 0.1 0.057 13.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4139) DnaJ_C PF01556.18 AET37531.1 - 4.7e-36 124.1 0.0 6.2e-36 123.7 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AET37531.1 - 4.1e-22 78.1 0.2 6.5e-22 77.4 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain WD40 PF00400.32 AET37532.1 - 4.2e-42 141.3 19.5 6.2e-11 42.7 0.1 8.0 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET37532.1 - 1e-12 48.2 2.8 0.0075 16.5 0.0 5.1 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AET37532.1 - 6.3e-11 41.6 9.4 0.0046 15.7 0.1 5.0 2 1 3 5 5 5 5 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 AET37532.1 - 1e-06 28.0 1.3 0.019 13.9 0.0 4.4 1 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 AET37532.1 - 2.5e-06 26.5 1.4 0.002 17.0 0.1 3.9 1 1 4 5 5 5 2 Nup133 N terminal like Frtz PF11768.8 AET37532.1 - 1.1e-05 24.0 0.0 5e-05 21.8 0.0 1.9 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 AET37532.1 - 0.00048 19.5 0.0 0.063 12.6 0.0 2.8 1 1 0 2 2 2 1 WD40-like domain Hira PF07569.11 AET37532.1 - 0.0022 17.8 1.9 0.077 12.7 0.2 3.7 2 1 2 4 4 4 2 TUP1-like enhancer of split DUF1513 PF07433.11 AET37532.1 - 0.0032 16.6 0.2 0.61 9.1 0.0 3.2 1 1 3 4 4 4 1 Protein of unknown function (DUF1513) PALB2_WD40 PF16756.5 AET37532.1 - 0.011 14.7 0.1 0.011 14.7 0.1 2.6 4 0 0 4 4 4 0 Partner and localizer of BRCA2 WD40 domain VID27 PF08553.10 AET37532.1 - 0.12 11.5 0.0 1 8.4 0.0 2.4 1 1 1 3 3 3 0 VID27 C-terminal WD40-like domain Ribosomal_L30 PF00327.20 AET37533.1 - 6.7e-11 41.9 1.0 1.4e-10 40.9 1.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Plasmodium_Vir PF05795.11 AET37533.1 - 0.42 10.0 2.4 1.3 8.3 2.2 1.7 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Iso_dh PF00180.20 AET37534.1 - 6.2e-123 410.4 0.0 7.1e-123 410.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase FAM25 PF15825.5 AET37534.1 - 0.092 13.1 0.6 0.092 13.1 0.6 1.8 2 0 0 2 2 2 0 FAM25 family Aminotran_5 PF00266.19 AET37535.1 - 4.4e-99 331.9 0.0 5.5e-99 331.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 AET37535.1 - 2.3e-08 33.7 0.7 9.1e-08 31.8 0.1 2.1 3 0 0 3 3 3 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 AET37535.1 - 6.5e-08 32.2 0.1 1e-07 31.5 0.1 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Pyridoxal_deC PF00282.19 AET37535.1 - 0.015 14.1 0.1 0.027 13.2 0.1 1.4 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain Mito_carr PF00153.27 AET37536.1 - 2e-51 171.9 3.6 3.4e-21 75.0 0.0 4.0 3 1 1 4 4 4 4 Mitochondrial carrier protein Dcc1 PF09724.9 AET37537.1 - 4.5e-73 246.4 0.0 5.2e-73 246.2 0.0 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 DUF3507 PF12015.8 AET37538.1 - 1.8e-64 216.8 0.0 3.7e-64 215.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) DUF2015 PF09435.10 AET37539.1 - 1.5e-34 118.2 0.0 1.9e-34 117.9 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) DUF3687 PF12459.8 AET37539.1 - 0.21 11.1 0.5 0.36 10.4 0.5 1.3 1 0 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein RRM_1 PF00076.22 AET37540.1 - 2.8e-43 145.6 0.1 1.3e-17 63.3 0.0 3.1 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_9 PF18444.1 AET37540.1 - 9.9e-05 22.1 0.1 0.71 9.8 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif DUF1325 PF07039.11 AET37541.1 - 1e-38 132.4 0.0 2e-38 131.5 0.0 1.5 2 0 0 2 2 2 1 SGF29 tudor-like domain Tudor_3 PF18115.1 AET37541.1 - 1.8e-05 24.4 0.0 4.9e-05 23.1 0.0 1.8 2 0 0 2 2 2 1 DNA repair protein Crb2 Tudor domain Agenet PF05641.12 AET37541.1 - 0.0002 21.7 0.1 0.078 13.5 0.0 2.3 2 0 0 2 2 2 2 Agenet domain DUF1474 PF07342.11 AET37541.1 - 0.019 15.5 0.1 0.033 14.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1474) DUF4537 PF15057.6 AET37541.1 - 0.019 15.0 0.0 0.042 13.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) Ribosomal_L27_C PF18471.1 AET37542.1 - 2.3e-84 282.6 12.2 2.7e-84 282.3 12.2 1.1 1 0 0 1 1 1 1 Ribosomal L27 protein C-terminal domain Ribosomal_L27 PF01016.19 AET37542.1 - 8.6e-32 109.0 0.0 1.5e-31 108.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal L27 protein Helicase_IV_N PF12462.8 AET37542.1 - 0.07 13.1 0.7 0.098 12.6 0.7 1.3 1 0 0 1 1 1 0 DNA helicase IV / RNA helicase N terminal ALS_ss_C PF10369.9 AET37543.1 - 7.1e-16 58.2 0.0 5.5e-15 55.3 0.0 2.3 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.25 AET37543.1 - 3.4e-10 39.5 0.1 6e-10 38.7 0.1 1.4 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 AET37543.1 - 4.1e-06 26.5 0.0 7.1e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 ACT domain Limkain-b1 PF11608.8 AET37543.1 - 0.0038 17.3 0.0 0.019 15.1 0.0 2.1 3 0 0 3 3 3 1 Limkain b1 Iso_dh PF00180.20 AET37544.1 - 1.6e-70 238.0 0.0 1.8e-70 237.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase HAD PF12710.7 AET37545.1 - 3e-20 73.4 0.0 3.9e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 AET37545.1 - 4.1e-09 36.2 0.5 5.9e-09 35.7 0.5 1.2 1 0 0 1 1 1 1 Putative Phosphatase UMPH-1 PF05822.12 AET37545.1 - 2.7e-08 33.6 0.0 3.1e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD_2 PF13419.6 AET37545.1 - 0.00019 21.6 0.1 0.041 14.0 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AET37545.1 - 0.02 15.2 0.3 0.96 9.7 0.0 2.7 1 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase UPF0052 PF01933.18 AET37546.1 - 4.5e-60 203.4 0.0 5.5e-60 203.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 DUF3842 PF12953.7 AET37546.1 - 0.0051 17.2 0.1 0.0099 16.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3842) EF-hand_7 PF13499.6 AET37547.1 - 4.5e-05 23.8 1.3 4.5e-05 23.8 1.3 2.5 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 AET37547.1 - 8.6e-05 22.2 3.9 0.019 14.9 0.3 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 AET37547.1 - 0.0012 18.2 4.2 0.024 14.1 0.6 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 AET37547.1 - 0.044 13.7 1.2 0.24 11.3 1.2 2.2 1 1 0 1 1 1 0 EF-hand domain pair LAL_C2 PF18603.1 AET37548.1 - 1.2 9.4 4.0 7.1 6.9 0.0 2.8 3 0 0 3 3 3 0 L-amino acid ligase C-terminal domain 2 PLA2_B PF01735.18 AET37549.1 - 1.1e-84 284.7 3.7 7e-79 265.5 0.7 2.1 2 0 0 2 2 2 2 Lysophospholipase catalytic domain CSF-1 PF05337.11 AET37549.1 - 0.49 10.5 2.7 0.68 10.0 0.2 2.3 2 1 1 3 3 3 0 Macrophage colony stimulating factor-1 (CSF-1) ABC_tran PF00005.27 AET37550.1 - 8.3e-44 149.4 0.0 8.4e-23 81.4 0.0 4.3 2 2 0 2 2 2 2 ABC transporter 4HB PF17947.1 AET37550.1 - 3.2e-27 94.4 0.0 1.3e-26 92.5 0.0 2.1 1 0 0 1 1 1 1 Four helical bundle domain AAA_21 PF13304.6 AET37550.1 - 2.5e-17 63.6 2.0 0.0043 16.9 0.0 4.5 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AET37550.1 - 1.8e-15 57.0 0.0 4.7e-06 26.2 0.0 4.1 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 AET37550.1 - 1.3e-09 38.8 5.8 0.00082 19.9 0.1 3.3 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 AET37550.1 - 2.1e-08 33.8 0.0 0.0082 15.9 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AET37550.1 - 3.7e-08 33.4 0.0 0.00084 19.3 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 AET37550.1 - 1.5e-07 31.5 0.0 0.0019 18.2 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 AET37550.1 - 1.6e-07 31.7 0.1 0.034 14.4 0.0 4.4 4 1 0 4 4 3 2 AAA domain Dynamin_N PF00350.23 AET37550.1 - 3.9e-07 30.3 0.0 1.1e-05 25.6 0.0 2.7 2 0 0 2 2 2 1 Dynamin family AAA_18 PF13238.6 AET37550.1 - 1.4e-06 28.9 0.0 0.065 13.8 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 AET37550.1 - 1.7e-06 28.4 0.0 0.011 15.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 AET37550.1 - 7.2e-06 26.5 0.1 0.7 10.3 0.0 4.1 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 AET37550.1 - 1.2e-05 25.7 0.0 0.13 12.7 0.0 2.9 2 0 0 2 2 2 2 RNA helicase MMS19_C PF12460.8 AET37550.1 - 1.3e-05 24.6 2.3 0.0098 15.0 0.1 3.2 3 0 0 3 3 3 1 RNAPII transcription regulator C-terminal MeaB PF03308.16 AET37550.1 - 1.6e-05 24.0 0.0 0.15 11.0 0.0 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 AET37550.1 - 2.4e-05 24.2 1.2 0.15 11.8 0.0 3.6 3 1 0 3 3 3 2 AAA ATPase domain AAA_33 PF13671.6 AET37550.1 - 3.3e-05 24.1 0.0 0.43 10.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain HEAT_2 PF13646.6 AET37550.1 - 0.00017 21.9 0.2 0.07 13.5 0.0 2.8 1 1 1 2 2 2 1 HEAT repeats AAA_27 PF13514.6 AET37550.1 - 0.00027 20.6 0.0 0.24 11.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 AET37550.1 - 0.00028 21.3 0.0 0.32 11.4 0.0 3.1 3 0 0 3 3 2 1 AAA ATPase domain DUF87 PF01935.17 AET37550.1 - 0.0011 19.2 1.4 0.35 10.9 0.0 3.7 4 0 0 4 4 3 1 Helicase HerA, central domain AAA_30 PF13604.6 AET37550.1 - 0.0015 18.2 0.2 2.7 7.6 0.0 3.3 4 0 0 4 4 3 1 AAA domain AAA_13 PF13166.6 AET37550.1 - 0.002 16.9 1.7 2.5 6.6 0.0 4.0 4 0 0 4 4 4 1 AAA domain AAA_24 PF13479.6 AET37550.1 - 0.002 17.9 0.3 1.7 8.3 0.0 3.3 4 0 0 4 4 2 1 AAA domain CLASP_N PF12348.8 AET37550.1 - 0.003 17.2 0.7 1.8 8.1 0.0 2.8 2 1 0 3 3 2 1 CLASP N terminal SbcCD_C PF13558.6 AET37550.1 - 0.0031 17.7 0.0 0.76 10.1 0.0 3.2 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit NACHT PF05729.12 AET37550.1 - 0.0032 17.4 0.0 1.5 8.7 0.0 2.9 3 0 0 3 3 2 1 NACHT domain Rad17 PF03215.15 AET37550.1 - 0.0053 16.7 0.0 2.6 7.9 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain PduV-EutP PF10662.9 AET37550.1 - 0.0059 16.3 0.0 0.25 11.1 0.0 2.8 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 AET37550.1 - 0.0059 16.2 0.4 3 7.4 0.0 3.2 4 0 0 4 4 2 1 CobW/HypB/UreG, nucleotide-binding domain ParcG PF10274.9 AET37550.1 - 0.006 16.7 0.3 3.8 7.6 0.0 3.0 2 1 0 3 3 3 0 Parkin co-regulated protein Vac14_Fab1_bd PF12755.7 AET37550.1 - 0.012 16.1 0.1 3.2 8.4 0.0 3.4 3 1 1 5 5 2 0 Vacuolar 14 Fab1-binding region ATPase_2 PF01637.18 AET37550.1 - 0.013 15.5 0.0 9.6 6.0 0.0 3.3 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 AET37550.1 - 0.015 15.3 0.0 8.9 6.4 0.0 3.1 3 0 0 3 3 2 0 AAA domain CLP1_P PF16575.5 AET37550.1 - 0.017 14.9 0.1 2 8.2 0.0 2.9 3 0 0 3 3 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Roc PF08477.13 AET37550.1 - 0.019 15.2 0.0 11 6.2 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 AET37550.1 - 0.021 14.6 0.0 7.9 6.2 0.0 3.3 3 0 0 3 3 3 0 IstB-like ATP binding protein Cytidylate_kin PF02224.18 AET37550.1 - 0.026 14.3 0.0 9.7 5.9 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase Mg_chelatase PF01078.21 AET37550.1 - 0.033 13.5 0.1 1.5 8.1 0.0 3.0 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 AET37550.1 - 0.046 13.6 0.0 14 5.5 0.0 3.0 2 0 0 2 2 2 0 NTPase IFRD PF05004.13 AET37550.1 - 0.046 12.8 0.3 0.12 11.4 0.2 1.7 1 1 0 1 1 1 0 Interferon-related developmental regulator (IFRD) UME PF08064.13 AET37550.1 - 0.05 13.5 0.3 1.2 9.0 0.3 2.8 2 1 1 3 3 2 0 UME (NUC010) domain G-alpha PF00503.20 AET37550.1 - 0.056 12.6 0.0 5.6 6.0 0.0 2.4 2 0 0 2 2 2 0 G-protein alpha subunit Ploopntkinase3 PF18751.1 AET37550.1 - 0.057 13.3 0.0 11 5.9 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 T2SSE PF00437.20 AET37550.1 - 0.065 12.3 0.0 0.67 9.0 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein HEAT_EZ PF13513.6 AET37550.1 - 0.07 13.7 8.7 5.4 7.6 0.1 4.9 5 1 1 6 6 3 0 HEAT-like repeat AAA_7 PF12775.7 AET37550.1 - 0.075 12.5 0.0 12 5.4 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region TsaE PF02367.17 AET37550.1 - 0.086 12.8 0.0 6.9 6.7 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 AET37550.1 - 0.09 12.0 0.2 21 4.3 0.0 3.2 3 0 0 3 3 3 0 Zeta toxin ATP_bind_1 PF03029.17 AET37550.1 - 0.094 12.5 1.6 7.7 6.2 0.1 3.0 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein MutS_V PF00488.21 AET37550.1 - 0.094 12.7 0.1 6.4 6.8 0.1 2.4 2 0 0 2 2 2 0 MutS domain V Adaptin_N PF01602.20 AET37550.1 - 0.1 11.1 6.0 0.96 7.9 1.2 2.9 1 1 1 3 3 3 0 Adaptin N terminal region Septin PF00735.18 AET37550.1 - 0.1 11.9 0.0 2.7 7.2 0.0 2.4 2 0 0 2 2 2 0 Septin MukB PF04310.12 AET37550.1 - 0.15 11.9 0.7 14 5.4 0.0 2.8 3 0 0 3 3 2 0 MukB N-terminal HEAT PF02985.22 AET37550.1 - 0.16 12.3 1.3 51 4.5 0.0 4.5 5 0 0 5 5 3 0 HEAT repeat AAA_17 PF13207.6 AET37550.1 - 0.7 10.3 3.6 27 5.2 0.3 3.7 3 1 0 3 3 2 0 AAA domain Pkinase PF00069.25 AET37551.1 - 4.5e-36 124.6 0.0 7.5e-36 123.8 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET37551.1 - 5.9e-11 42.1 0.0 1.1e-10 41.3 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET37551.1 - 0.0039 16.6 0.1 0.17 11.2 0.1 2.4 2 1 1 3 3 3 2 Kinase-like Sugar_tr PF00083.24 AET37552.1 - 2.1e-174 580.7 32.6 2.3e-174 580.5 32.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AET37552.1 - 4.5e-35 121.2 39.2 4.4e-28 98.2 14.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1772 PF08592.11 AET37552.1 - 0.28 11.5 12.3 1.3 9.4 1.7 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF1772) tRNA-synt_1d PF00750.19 AET37553.1 - 7e-122 406.7 7.6 8.9e-122 406.4 7.6 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 AET37553.1 - 1.4e-30 105.9 0.1 4.9e-29 100.9 0.0 2.5 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 AET37553.1 - 1.1e-06 29.1 0.0 2.7e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain Sugar_tr PF00083.24 AET37554.1 - 2.9e-174 580.2 34.0 3.3e-174 580.0 34.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AET37554.1 - 1.3e-35 123.0 43.2 2.5e-28 99.0 17.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1772 PF08592.11 AET37554.1 - 6 7.2 17.1 0.96 9.8 1.3 3.8 3 1 1 4 4 4 0 Domain of unknown function (DUF1772) Svf1_C PF17187.4 AET37555.1 - 7.7e-63 211.2 1.6 9e-63 211.0 0.2 1.8 2 1 0 2 2 2 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 AET37555.1 - 4.8e-61 205.6 0.3 7.9e-61 204.9 0.3 1.4 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain Sod_Fe_C PF02777.18 AET37556.1 - 7.1e-13 48.6 0.2 1.2e-09 38.3 0.2 2.3 1 1 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Pal1 PF08316.11 AET37557.1 - 3.2e-52 176.9 1.6 9.6e-52 175.4 1.6 1.9 1 0 0 1 1 1 1 Pal1 cell morphology protein Sec23_trunk PF04811.15 AET37558.1 - 5.2e-55 186.7 0.0 9.7e-55 185.8 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 AET37558.1 - 6.2e-19 67.7 0.3 1.3e-18 66.7 0.3 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 AET37558.1 - 3.1e-13 50.3 0.0 6.7e-13 49.2 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 AET37558.1 - 3.3e-11 43.0 8.8 7.5e-11 41.9 8.8 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 AET37558.1 - 2.1e-05 24.3 0.3 0.00015 21.6 0.0 2.5 3 0 0 3 3 3 1 Gelsolin repeat Asp PF00026.23 AET37559.1 - 1e-26 94.1 0.8 3.7e-26 92.3 0.8 1.9 1 1 0 1 1 1 1 Eukaryotic aspartyl protease FAT PF02259.23 AET37560.1 - 5.7e-72 242.8 8.7 1.3e-71 241.6 8.7 1.7 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 AET37560.1 - 1.1e-50 172.8 1.5 4.6e-50 170.8 1.5 2.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 AET37560.1 - 0.00066 19.4 0.0 0.0019 18.0 0.0 1.9 1 0 0 1 1 1 1 FATC domain PXA PF02194.15 AET37560.1 - 0.0063 16.5 4.9 1.4 8.9 0.1 4.3 3 0 0 3 3 3 2 PXA domain NusA_N PF08529.11 AET37560.1 - 0.089 13.1 0.1 6.8 7.1 0.0 3.1 2 0 0 2 2 2 0 NusA N-terminal domain TAN PF11640.8 AET37560.1 - 0.28 11.3 4.6 4.4 7.4 0.1 4.9 5 0 0 5 5 5 0 Telomere-length maintenance and DNA damage repair PGP_phosphatase PF09419.10 AET37561.1 - 7.9e-67 224.1 0.0 8.9e-67 223.9 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 AET37561.1 - 5.1e-06 26.5 0.0 8e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 AET37561.1 - 0.16 12.3 0.0 0.24 11.6 0.0 1.3 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase zf-C3HC4_3 PF13920.6 AET37562.1 - 2e-09 37.2 6.5 2e-09 37.2 6.5 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AET37562.1 - 4.8e-05 23.1 9.5 4.8e-05 23.1 9.5 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AET37562.1 - 0.0048 16.7 9.4 0.0048 16.7 9.4 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AET37562.1 - 0.0059 16.9 8.5 0.0059 16.9 8.5 3.3 3 1 0 3 3 3 1 Ring finger domain PBECR3 PF18812.1 AET37562.1 - 0.11 12.5 1.5 0.63 10.0 0.1 2.5 1 1 1 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 zf-Di19 PF05605.12 AET37562.1 - 0.24 11.7 0.1 0.24 11.7 0.1 4.4 4 1 1 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding Pex2_Pex12 PF04757.14 AET37563.1 - 7.3e-34 117.3 4.2 9.3e-34 117.0 4.2 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.6 AET37563.1 - 3.6e-08 33.6 18.1 6.2e-08 32.8 18.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 AET37563.1 - 3.2e-07 30.1 18.7 5e-07 29.5 18.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AET37563.1 - 1.6e-05 24.6 16.1 2.9e-05 23.8 16.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AET37563.1 - 4.4e-05 23.2 18.1 7.3e-05 22.5 18.1 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 AET37563.1 - 7.1e-05 22.6 17.2 0.00013 21.7 17.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AET37563.1 - 0.00095 19.1 11.3 0.00095 19.1 11.3 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 AET37563.1 - 0.0034 17.5 16.7 0.0072 16.5 16.7 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 AET37563.1 - 0.008 16.1 13.7 0.012 15.5 13.2 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 AET37563.1 - 0.013 15.8 14.9 0.025 14.9 14.9 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain MIX PF18529.1 AET37563.1 - 0.027 14.2 0.0 0.048 13.4 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial membrane-anchored proteins zf-RING_6 PF14835.6 AET37563.1 - 1.4 8.8 11.2 2.9 7.8 11.2 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein UNC45-central PF11701.8 AET37564.1 - 3e-21 76.0 2.0 3e-21 76.0 2.0 2.9 3 0 0 3 3 3 1 Myosin-binding striated muscle assembly central BK_channel_a PF03493.18 AET37564.1 - 0.013 15.7 0.0 0.54 10.5 0.0 2.5 2 0 0 2 2 2 0 Calcium-activated BK potassium channel alpha subunit AhpC-TSA_2 PF13911.6 AET37564.1 - 0.055 13.6 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme Ank_2 PF12796.7 AET37565.1 - 9.4e-28 96.6 0.0 4.5e-11 43.2 0.0 3.8 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) DHHC PF01529.20 AET37565.1 - 2.6e-22 79.4 10.1 2.6e-22 79.4 10.1 2.8 2 1 1 3 3 3 1 DHHC palmitoyltransferase Ank_3 PF13606.6 AET37565.1 - 2e-21 73.8 0.4 0.003 17.9 0.0 7.1 7 0 0 7 7 7 4 Ankyrin repeat Ank_4 PF13637.6 AET37565.1 - 3.4e-21 75.3 0.1 1.3e-05 25.6 0.0 5.5 4 1 1 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 AET37565.1 - 1.2e-20 72.9 0.0 0.0023 18.3 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 AET37565.1 - 3.3e-20 71.9 0.1 5.9e-05 23.3 0.0 4.5 3 1 1 4 4 4 4 Ankyrin repeats (many copies) XPG_N PF00752.17 AET37566.1 - 1.9e-24 86.1 0.0 3.9e-24 85.0 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 AET37566.1 - 2.3e-20 72.7 0.0 5e-20 71.7 0.0 1.6 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 AET37566.1 - 5.2e-05 23.8 0.0 0.0012 19.4 0.0 2.5 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_2 PF12826.7 AET37566.1 - 0.012 15.7 0.0 0.036 14.2 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Katanin_con80 PF13925.6 AET37566.1 - 0.033 14.2 0.6 9.5 6.2 0.0 3.3 3 0 0 3 3 3 0 con80 domain of Katanin XPG_I_2 PF12813.7 AET37566.1 - 0.095 12.2 0.0 0.22 11.0 0.0 1.6 1 0 0 1 1 1 0 XPG domain containing Sugar_tr PF00083.24 AET37567.1 - 9.6e-60 202.7 21.6 1.5e-58 198.7 21.6 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AET37567.1 - 5.4e-17 61.7 40.8 3.6e-08 32.7 20.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DMT_YdcZ PF04657.13 AET37567.1 - 0.058 13.7 14.0 0.026 14.8 4.1 3.5 3 0 0 3 3 3 0 Putative inner membrane exporter, YdcZ HLH PF00010.26 AET37568.1 - 4.1e-19 68.3 0.6 8.9e-19 67.2 0.6 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF1160 PF06648.11 AET37568.1 - 0.076 13.0 0.8 0.18 11.8 0.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1160) Fasciclin PF02469.22 AET37569.1 - 1e-06 29.0 0.0 1.9e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Fasciclin domain PDCD2_C PF04194.13 AET37570.1 - 5.4e-39 134.1 0.0 1.5e-36 126.1 0.0 2.5 2 0 0 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain GTP_EFTU PF00009.27 AET37571.1 - 1.9e-29 102.6 6.6 1.2e-27 96.7 6.6 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 AET37571.1 - 4.5e-24 84.6 1.7 5.5e-24 84.3 0.0 2.0 2 0 0 2 2 2 1 Translation-initiation factor 2 IF2_N PF04760.15 AET37571.1 - 5e-08 32.6 0.0 1.3e-07 31.3 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region MMR_HSR1 PF01926.23 AET37571.1 - 2.1e-07 31.0 0.5 2.1e-07 31.0 0.5 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AET37571.1 - 0.00056 19.9 4.8 0.0077 16.2 2.7 2.7 1 1 1 2 2 2 1 RsgA GTPase SRPRB PF09439.10 AET37571.1 - 0.011 15.2 0.3 0.011 15.2 0.3 1.8 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Roc PF08477.13 AET37571.1 - 0.014 15.6 0.1 0.031 14.5 0.1 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 AET37571.1 - 0.023 14.3 1.7 0.025 14.2 0.4 1.8 2 0 0 2 2 2 0 Ras family PduV-EutP PF10662.9 AET37571.1 - 0.047 13.4 1.7 0.19 11.5 1.7 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 AET37571.1 - 0.068 13.2 3.0 11 6.1 0.2 3.3 2 1 1 3 3 3 0 Dynamin family TauD PF02668.16 AET37572.1 - 3.3e-31 109.1 0.0 5.4e-31 108.4 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 AET37572.1 - 1.1e-09 38.8 1.5 1.7e-08 35.0 0.4 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF971) CsiD PF08943.10 AET37572.1 - 0.0017 17.6 0.0 0.49 9.4 0.0 2.2 2 0 0 2 2 2 2 CsiD PGK PF00162.19 AET37575.1 - 2.9e-150 500.4 0.1 3.3e-150 500.3 0.1 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DUF4162 PF13732.6 AET37575.1 - 0.16 12.7 0.0 0.94 10.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) DNA_pol_B_palm PF14792.6 AET37576.1 - 2.4e-15 56.7 0.1 1.1e-14 54.6 0.1 2.1 1 1 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 AET37576.1 - 3.3e-15 56.0 0.3 1.4e-14 54.0 0.0 2.1 2 0 0 2 2 2 1 DNA polymerase beta thumb HHH_8 PF14716.6 AET37576.1 - 4.9e-11 42.8 0.0 1.4e-10 41.4 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 AET37576.1 - 9e-11 41.4 0.4 2.5e-10 40.0 0.2 1.9 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda BRCT_2 PF16589.5 AET37576.1 - 7.8e-05 23.0 0.0 0.00033 21.0 0.0 2.1 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain NTP_transf_2 PF01909.23 AET37576.1 - 0.0082 16.4 0.0 0.035 14.4 0.0 2.1 2 0 0 2 2 2 1 Nucleotidyltransferase domain BRCT PF00533.26 AET37576.1 - 0.13 12.7 0.1 0.43 11.0 0.0 2.1 2 1 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain HAD PF12710.7 AET37577.1 - 7.3e-08 33.0 0.1 1.3e-07 32.2 0.1 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 AET37577.1 - 0.19 11.1 0.4 3.6 6.9 0.0 2.1 2 0 0 2 2 2 0 Putative Phosphatase DUF2373 PF10180.9 AET37578.1 - 7.7e-25 86.5 0.0 1.5e-24 85.6 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) Swm2 PF17083.5 AET37578.1 - 0.0076 16.3 0.1 0.028 14.4 0.1 2.0 2 1 0 2 2 2 1 Nucleolar protein Swm2 RNA_pol_Rpb4 PF03874.16 AET37578.1 - 0.12 12.7 0.1 20 5.5 0.0 2.6 2 1 1 3 3 3 0 RNA polymerase Rpb4 VP4_2 PF08935.10 AET37578.1 - 0.33 11.6 3.7 0.19 12.4 0.8 2.0 2 0 0 2 2 2 0 Viral protein VP4 subunit Sugar_tr PF00083.24 AET37579.1 - 2.6e-106 356.2 26.5 3.3e-106 355.9 26.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AET37579.1 - 3.7e-24 85.3 30.5 1.7e-23 83.1 22.1 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Frag1 PF10277.9 AET37580.1 - 1.6e-28 99.8 10.8 1.6e-28 99.8 10.8 4.3 4 2 0 4 4 4 1 Frag1/DRAM/Sfk1 family Exo_endo_phos PF03372.23 AET37580.1 - 0.023 14.2 0.0 0.043 13.3 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Alpha-amylase_C PF02806.18 AET37581.1 - 4.2e-26 91.2 0.1 1.2e-25 89.8 0.1 1.8 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 AET37581.1 - 6e-16 58.9 0.1 1e-14 54.8 0.1 2.3 1 1 1 2 2 2 1 Alpha amylase, catalytic domain CBM_48 PF02922.18 AET37581.1 - 1.9e-15 57.0 0.0 4.7e-15 55.7 0.0 1.8 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Glyco_hydro_66 PF13199.6 AET37581.1 - 0.0034 16.1 0.0 0.0057 15.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 66 Arm-DNA-bind_1 PF09003.10 AET37581.1 - 0.051 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage lambda integrase, Arm DNA-binding domain UQ_con PF00179.26 AET37582.1 - 7.7e-40 135.8 0.1 1e-39 135.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Snurportin1 PF11538.8 AET37583.1 - 0.54 10.5 5.4 1.5 9.1 5.4 1.8 1 1 1 2 2 2 0 Snurportin1 LSM PF01423.22 AET37584.1 - 2.3e-08 33.6 0.3 4.7e-08 32.6 0.1 1.6 2 0 0 2 2 2 1 LSM domain IPT PF01745.16 AET37584.1 - 0.12 11.7 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Isopentenyl transferase PfkB PF00294.24 AET37585.1 - 2.6e-05 23.7 0.0 4.4e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Arm PF00514.23 AET37586.1 - 1.1e-68 225.3 33.0 1.4e-11 44.0 0.0 11.1 12 1 1 13 13 13 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 AET37586.1 - 1e-22 80.1 13.1 0.00034 21.0 0.0 7.6 5 1 2 7 7 7 6 HEAT-like repeat HEAT_2 PF13646.6 AET37586.1 - 3.4e-16 59.4 6.4 0.0072 16.7 0.0 6.5 3 2 2 6 6 6 3 HEAT repeats HEAT PF02985.22 AET37586.1 - 4.9e-14 51.2 15.5 0.056 13.7 0.2 9.1 8 0 0 8 8 8 5 HEAT repeat Adaptin_N PF01602.20 AET37586.1 - 1.1e-12 47.4 10.5 2e-08 33.3 3.5 2.2 1 1 1 2 2 2 2 Adaptin N terminal region Arm_2 PF04826.13 AET37586.1 - 1.5e-11 44.3 7.4 2.9e-08 33.5 2.1 2.7 2 1 0 2 2 2 2 Armadillo-like KAP PF05804.12 AET37586.1 - 2.7e-08 32.5 1.5 2.7e-08 32.5 1.5 2.5 2 1 0 2 2 2 1 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.14 AET37586.1 - 1.2e-06 28.0 5.0 0.0068 15.7 0.9 3.6 1 1 1 2 2 2 2 V-ATPase subunit H V-ATPase_H_C PF11698.8 AET37586.1 - 6.2e-06 26.3 4.5 0.011 15.8 0.1 5.1 3 2 3 6 6 6 1 V-ATPase subunit H Cnd1 PF12717.7 AET37586.1 - 8e-06 26.0 9.3 0.056 13.5 0.3 5.0 2 2 2 5 5 5 3 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 AET37586.1 - 3.2e-05 23.9 8.3 0.0091 15.9 0.4 4.2 3 2 1 4 4 4 1 Domain of unknown function (DUF3361) Tti2 PF10521.9 AET37586.1 - 0.00025 20.7 0.0 0.11 12.1 0.0 3.3 3 0 0 3 3 3 1 Tti2 family Vac14_Fab1_bd PF12755.7 AET37586.1 - 0.00068 20.2 0.5 1.6 9.4 0.0 3.6 2 1 0 3 3 2 2 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 AET37586.1 - 0.097 12.9 3.4 71 3.6 0.0 5.2 4 2 3 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 YjeF_N PF03853.15 AET37587.1 - 3.1e-30 105.3 0.0 5e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 AET37587.1 - 2.7e-06 28.2 7.9 2.7e-06 28.2 7.9 2.5 1 1 1 2 2 2 1 FDF domain 40S_S4_C PF16121.5 AET37587.1 - 0.12 12.0 0.1 0.36 10.5 0.1 1.7 1 0 0 1 1 1 0 40S ribosomal protein S4 C-terminus CDK2AP PF09806.9 AET37587.1 - 6 6.9 9.3 0.58 10.2 3.8 2.0 2 1 1 3 3 3 0 Cyclin-dependent kinase 2-associated protein Phosphodiest PF01663.22 AET37588.1 - 1.5e-61 209.0 1.0 2.4e-61 208.3 1.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4573 PF15140.6 AET37588.1 - 9.5e-07 28.8 19.4 2e-06 27.7 19.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4573) Amelogenin PF02948.15 AET37588.1 - 0.076 13.7 45.6 0.17 12.5 6.7 4.0 2 1 2 4 4 4 0 Amelogenin Apq12 PF12716.7 AET37588.1 - 7.3 6.6 7.2 4 7.4 1.1 2.4 2 0 0 2 2 2 0 Nuclear pore assembly and biogenesis SR-25 PF10500.9 AET37589.1 - 0.0052 16.4 11.8 0.0074 15.9 11.8 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 AET37589.1 - 0.87 7.6 7.6 1.1 7.2 7.6 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TACC_C PF05010.14 AET37590.1 - 0.0039 17.0 0.5 0.047 13.5 0.1 2.2 2 0 0 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF87 PF01935.17 AET37590.1 - 0.074 13.1 1.4 0.1 12.7 1.4 1.2 1 0 0 1 1 1 0 Helicase HerA, central domain zf-Nse PF11789.8 AET37591.1 - 4.5e-19 68.0 0.2 9.6e-19 67.0 0.2 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 AET37591.1 - 9.6e-09 35.1 2.0 1.2e-08 34.9 0.8 1.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 AET37591.1 - 1.8e-05 24.5 0.2 3.9e-05 23.4 0.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) U-box PF04564.15 AET37591.1 - 8.2e-05 22.7 0.1 0.0003 20.9 0.1 1.9 2 0 0 2 2 2 1 U-box domain zf-RING_2 PF13639.6 AET37591.1 - 0.00089 19.5 0.4 0.00089 19.5 0.4 1.7 2 0 0 2 2 2 1 Ring finger domain zf-MIZ PF02891.20 AET37591.1 - 0.0013 18.4 0.3 0.0024 17.6 0.3 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger Rtf2 PF04641.12 AET37591.1 - 0.008 15.6 0.2 0.014 14.8 0.2 1.4 1 0 0 1 1 1 1 Rtf2 RING-finger zf-C3HC4 PF00097.25 AET37591.1 - 0.013 15.4 0.1 0.03 14.2 0.1 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 AET37591.1 - 0.046 14.0 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 AET37591.1 - 0.1 12.3 0.1 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Zn-ribbon_8 PF09723.10 AET37591.1 - 0.15 12.2 0.4 0.44 10.7 0.4 1.8 1 0 0 1 1 1 0 Zinc ribbon domain tRNA-synt_2 PF00152.20 AET37592.1 - 8.5e-77 258.3 0.0 1.1e-76 257.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AET37592.1 - 1.3e-07 31.5 0.0 2.4e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 AET37592.1 - 0.034 13.6 0.0 1.3 8.5 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.25 AET37592.1 - 0.051 13.6 0.0 0.28 11.1 0.0 2.2 1 1 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) TPP_enzyme_N PF02776.18 AET37593.1 - 3.6e-37 127.6 0.0 7e-37 126.7 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 AET37593.1 - 4.7e-25 87.9 0.0 1e-24 86.8 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 AET37593.1 - 4.8e-23 81.6 0.9 1.8e-22 79.7 0.2 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 AET37593.1 - 0.062 12.5 0.1 0.11 11.7 0.1 1.3 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase Sigma70_ner PF04546.13 AET37594.1 - 0.061 13.2 8.5 0.46 10.3 3.3 2.6 2 0 0 2 2 2 0 Sigma-70, non-essential region YL1 PF05764.13 AET37594.1 - 0.78 9.8 14.3 0.35 11.0 10.9 2.0 2 0 0 2 2 2 0 YL1 nuclear protein FAM176 PF14851.6 AET37594.1 - 3.8 7.2 7.4 4.6 6.9 4.6 2.4 2 0 0 2 2 2 0 FAM176 family zf-Tim10_DDP PF02953.15 AET37595.1 - 1.5e-21 75.8 6.9 2e-21 75.4 6.8 1.3 1 1 0 1 1 1 1 Tim10/DDP family zinc finger Phasin_2 PF09361.10 AET37595.1 - 0.019 15.3 0.1 0.23 11.8 0.0 2.0 1 1 1 2 2 2 0 Phasin protein DUF842 PF05811.13 AET37595.1 - 0.098 12.4 7.1 0.44 10.2 7.1 1.8 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) Tam41_Mmp37 PF09139.11 AET37595.1 - 0.098 12.1 0.5 0.11 12.0 0.5 1.0 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial OMPdecase PF00215.24 AET37596.1 - 1.6e-74 250.3 0.0 1.9e-74 250.1 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Mito_carr PF00153.27 AET37597.1 - 3.6e-10 39.6 3.0 9e-08 31.9 0.1 3.1 3 1 0 3 3 3 2 Mitochondrial carrier protein Sec7 PF01369.20 AET37598.1 - 3.5e-70 235.4 0.8 8.6e-70 234.1 0.8 1.7 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 AET37598.1 - 1.6e-14 54.1 0.6 1.6e-14 54.1 0.6 3.7 4 0 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 AET37598.1 - 3.7e-06 26.7 2.1 3.7e-06 26.7 2.1 3.4 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 DivIVA PF05103.13 AET37598.1 - 0.14 12.2 3.2 0.31 11.1 3.2 1.6 1 0 0 1 1 1 0 DivIVA protein Pro_isomerase PF00160.21 AET37599.1 - 2.5e-41 141.6 0.1 4e-41 140.9 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 AET37599.1 - 9.9e-09 34.7 14.6 1.7e-08 33.9 3.9 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 AET37599.1 - 3.8e-08 32.8 12.8 5.9e-06 26.0 1.9 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 AET37599.1 - 1.6e-05 25.1 0.4 0.02 15.2 0.2 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 AET37599.1 - 0.0005 20.7 0.0 0.0047 17.6 0.0 2.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 AET37599.1 - 0.0024 18.0 13.3 0.0033 17.5 1.1 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 AET37599.1 - 0.029 15.0 1.2 0.12 13.1 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 AET37599.1 - 0.75 9.9 6.0 1.2 9.2 0.6 2.6 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 AET37599.1 - 0.96 9.2 9.5 11 5.7 0.7 3.4 2 1 0 2 2 2 0 TPR repeat TPR_17 PF13431.6 AET37599.1 - 2 9.0 5.6 2.8 8.5 0.2 3.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Rav1p_C PF12234.8 AET37600.1 - 1.7e-237 789.9 8.8 1.7e-237 789.9 8.8 1.5 2 0 0 2 2 2 1 RAVE protein 1 C terminal WD40 PF00400.32 AET37600.1 - 0.026 15.4 8.2 0.96 10.4 0.2 5.5 5 0 0 5 5 5 0 WD domain, G-beta repeat Pet191_N PF10203.9 AET37601.1 - 3.2e-24 85.0 4.0 4.7e-24 84.5 4.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 AET37601.1 - 0.064 13.3 3.9 1 9.4 0.2 2.6 2 1 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 AET37601.1 - 1.7 8.7 5.7 12 6.0 0.3 3.2 1 1 2 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, SNF2_N PF00176.23 AET37602.1 - 1.3e-70 237.9 0.2 1.3e-70 237.9 0.2 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AET37602.1 - 1.3e-19 70.6 0.0 7.8e-19 68.1 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET37602.1 - 3.6e-08 33.6 2.5 5.4e-08 33.0 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UvsW PF11637.8 AET37602.1 - 0.0064 16.6 7.2 0.58 10.3 0.1 4.6 5 0 0 5 5 5 2 ATP-dependant DNA helicase UvsW DUF601 PF04642.12 AET37602.1 - 0.29 10.6 4.6 0.22 11.0 2.3 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF601 DUF2235 PF09994.9 AET37603.1 - 1.8e-80 270.4 0.0 2.8e-80 269.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) UCR_TM PF02921.14 AET37604.1 - 1.1e-11 45.1 0.4 3.2e-11 43.6 0.4 1.9 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.26 AET37604.1 - 3.4e-11 42.9 0.0 6.4e-11 42.1 0.0 1.4 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain DUF2516 PF10724.9 AET37604.1 - 0.062 13.6 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2516) Transp_cyt_pur PF02133.15 AET37604.1 - 0.12 11.1 0.1 0.15 10.8 0.1 1.1 1 0 0 1 1 1 0 Permease for cytosine/purines, uracil, thiamine, allantoin HECT PF00632.25 AET37605.1 - 9.2e-85 284.8 1.8 6e-84 282.1 0.3 2.3 2 0 0 2 2 2 2 HECT-domain (ubiquitin-transferase) Vfa1 PF08432.10 AET37606.1 - 0.012 15.9 0.0 0.026 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Ribosomal_L7Ae PF01248.26 AET37608.1 - 1.2e-27 95.5 0.0 1.4e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 AET37608.1 - 0.0011 18.8 0.0 0.0014 18.4 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 AET37608.1 - 0.012 15.6 0.0 0.013 15.6 0.0 1.1 1 0 0 1 1 1 0 RNase P subunit Pop3 Pico_P2B PF01552.17 AET37608.1 - 0.05 13.7 0.0 0.082 13.1 0.0 1.4 1 1 0 1 1 1 0 Picornavirus 2B protein Voltage_CLC PF00654.20 AET37609.1 - 3.7e-79 266.5 20.7 3.7e-79 266.5 20.7 1.7 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 AET37609.1 - 1.1e-12 48.2 0.0 2.2e-07 31.2 0.0 2.9 3 0 0 3 3 3 2 CBS domain Urb2 PF10441.9 AET37610.1 - 1.1e-59 201.8 4.0 1.1e-59 201.8 4.0 2.3 2 0 0 2 2 2 1 Urb2/Npa2 family Nucleopor_Nup85 PF07575.13 AET37611.1 - 8.1e-189 628.8 14.8 9.3e-189 628.6 14.8 1.0 1 0 0 1 1 1 1 Nup85 Nucleoporin ATP-synt_C PF00137.21 AET37612.1 - 6.1e-34 116.2 32.0 3.1e-22 78.7 13.4 2.2 2 0 0 2 2 2 2 ATP synthase subunit C DUF2970 PF11174.8 AET37612.1 - 0.42 10.5 7.7 0.41 10.5 0.7 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) CDC27 PF09507.10 AET37613.1 - 0.003 17.0 26.3 0.071 12.5 26.4 2.3 1 1 0 1 1 1 1 DNA polymerase subunit Cdc27 Caprin-1_dimer PF18293.1 AET37613.1 - 0.0076 16.7 1.3 0.017 15.6 1.3 1.5 1 0 0 1 1 1 1 Caprin-1 dimerization domain CTK3_C PF12350.8 AET37613.1 - 2.1 8.5 8.5 2.4 8.4 7.0 1.9 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 C-terminus SpoIIIAH PF12685.7 AET37613.1 - 5.5 6.8 15.6 0.07 12.9 7.3 2.0 2 1 0 2 2 2 0 SpoIIIAH-like protein zf-C2H2 PF00096.26 AET37614.1 - 9.7e-07 28.9 9.1 0.0071 16.7 0.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AET37614.1 - 0.00044 20.5 0.3 0.00044 20.5 0.3 3.5 3 0 0 3 3 3 1 Zinc-finger double domain FOXP-CC PF16159.5 AET37614.1 - 0.0005 20.6 2.0 0.0029 18.2 0.1 2.6 2 0 0 2 2 2 1 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 AET37614.1 - 0.0017 19.0 11.9 0.058 14.2 2.4 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger Nipped-B_C PF12830.7 AET37614.1 - 0.07 13.1 1.5 0.094 12.6 0.1 1.9 2 0 0 2 2 2 0 Sister chromatid cohesion C-terminus zf-C2H2_jaz PF12171.8 AET37614.1 - 0.14 12.5 3.2 0.2 12.0 0.3 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 AET37614.1 - 0.27 11.0 3.4 3.3 7.5 0.1 2.8 2 0 0 2 2 2 0 C2H2-type zinc-finger domain F-box-like PF12937.7 AET37615.1 - 1.6e-10 40.7 0.2 3.5e-10 39.6 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 AET37615.1 - 1.4e-09 37.6 0.2 3.1e-09 36.5 0.2 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 AET37615.1 - 0.00099 19.0 0.0 0.0023 17.8 0.0 1.7 1 0 0 1 1 1 1 F-box FAD_binding_6 PF00970.24 AET37616.1 - 9.4e-28 96.5 0.0 1.5e-27 95.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 AET37616.1 - 9.2e-27 93.9 0.0 1.5e-26 93.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 AET37616.1 - 6.5e-06 26.3 0.0 0.00024 21.3 0.0 2.2 1 1 1 2 2 2 1 Ferric reductase NAD binding domain DNA_pol3_a_NII PF11490.8 AET37616.1 - 0.14 12.0 0.2 3.9 7.4 0.0 2.2 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II ALO PF04030.14 AET37617.1 - 5.7e-105 350.8 0.9 5.7e-105 350.8 0.9 1.5 2 0 0 2 2 2 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 AET37617.1 - 9.4e-28 96.7 0.0 1.4e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain SIS_2 PF13580.6 AET37617.1 - 0.037 14.1 0.0 0.37 10.8 0.0 2.2 2 0 0 2 2 2 0 SIS domain BBE PF08031.12 AET37617.1 - 0.052 13.7 0.5 0.17 12.0 0.1 2.1 2 0 0 2 2 2 0 Berberine and berberine like Tubulin PF00091.25 AET37618.1 - 3.8e-67 226.3 0.0 5.9e-67 225.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 AET37618.1 - 1.6e-49 167.2 0.1 2.5e-49 166.6 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Sugar_tr PF00083.24 AET37619.1 - 6.2e-45 153.9 18.4 8.6e-45 153.4 18.4 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AET37619.1 - 2.5e-20 72.7 16.0 1.8e-11 43.6 12.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DMA PF03474.14 AET37619.1 - 0.18 11.4 0.1 3.7 7.2 0.0 2.5 2 0 0 2 2 2 0 DMRTA motif SQS_PSY PF00494.19 AET37620.1 - 4.3e-40 137.9 0.0 6.2e-40 137.4 0.0 1.3 1 0 0 1 1 1 1 Squalene/phytoene synthase GerD PF17898.1 AET37620.1 - 3.3 7.7 5.3 8.5 6.4 1.9 2.7 2 1 1 3 3 3 0 Spore germination GerD central core domain Pept_tRNA_hydro PF01195.19 AET37621.1 - 1.9e-32 112.6 0.0 2.3e-32 112.3 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase Gtr1_RagA PF04670.12 AET37622.1 - 7.6e-95 316.7 4.9 1.1e-94 316.1 1.6 2.0 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Ras PF00071.22 AET37622.1 - 6.6e-09 35.6 0.1 1.2e-08 34.7 0.1 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET37622.1 - 1.4e-08 34.9 0.0 3.3e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET37622.1 - 2.7e-08 33.5 0.7 4.5e-08 32.8 0.0 1.8 2 1 1 3 3 3 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AET37622.1 - 6.7e-08 32.6 0.0 2.1e-07 31.0 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 AET37622.1 - 0.006 17.1 0.3 0.014 15.9 0.1 1.9 2 1 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 AET37622.1 - 0.0081 16.1 0.9 0.33 10.9 0.1 2.5 2 0 0 2 2 2 1 RsgA GTPase Guanylate_kin PF00625.21 AET37622.1 - 0.023 14.4 2.6 0.062 13.0 0.4 2.6 2 1 0 2 2 2 0 Guanylate kinase AIG1 PF04548.16 AET37622.1 - 0.033 13.5 0.7 0.34 10.2 0.1 2.3 1 1 1 2 2 2 0 AIG1 family DUF815 PF05673.13 AET37622.1 - 0.036 13.2 0.2 0.092 11.9 0.0 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF815) CRISPR_Cas9_WED PF18061.1 AET37622.1 - 0.096 12.8 1.2 0.17 12.0 0.1 2.0 2 0 0 2 2 2 0 CRISPR-Cas9 WED domain AAA_29 PF13555.6 AET37622.1 - 0.14 11.9 0.2 0.3 10.9 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Pyr_redox_2 PF07992.14 AET37623.1 - 3.5e-46 157.8 0.0 4.4e-46 157.4 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AET37623.1 - 5.6e-13 49.3 0.1 2e-09 37.9 0.2 3.1 2 2 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AET37623.1 - 7.4e-06 25.4 0.3 0.87 8.8 0.0 3.1 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Mesothelin PF06060.12 AET37623.1 - 0.11 10.7 0.0 0.2 9.8 0.0 1.3 1 0 0 1 1 1 0 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) DUF1451 PF07295.11 AET37623.1 - 0.13 12.3 0.1 0.22 11.5 0.1 1.3 1 0 0 1 1 1 0 Zinc-ribbon containing domain Torus PF16131.5 AET37624.1 - 5.5e-33 113.9 0.8 8.1e-33 113.4 0.0 1.7 2 0 0 2 2 2 1 Torus domain RRM_1 PF00076.22 AET37624.1 - 4.3e-07 29.6 0.1 1.4e-06 28.0 0.2 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 AET37624.1 - 0.052 13.6 0.0 0.086 12.8 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 AET37624.1 - 0.061 13.4 3.5 0.38 10.8 3.5 2.2 1 1 0 1 1 1 0 RNA binding motif zf-CCCH_4 PF18044.1 AET37624.1 - 0.1 12.5 9.7 0.19 11.6 9.7 1.5 1 0 0 1 1 1 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 AET37624.1 - 9.7 6.4 9.2 5.3 7.2 7.0 1.8 2 0 0 2 2 2 0 Zinc finger domain DEAD PF00270.29 AET37625.1 - 4.9e-48 163.2 0.8 9.3e-47 159.0 0.0 2.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET37625.1 - 2.4e-33 114.8 0.0 8e-32 109.9 0.1 3.1 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET37625.1 - 1.5e-05 25.0 0.0 4.6e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 AET37625.1 - 0.03 13.1 0.1 0.093 11.5 0.1 1.9 2 1 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Tyr-DNA_phospho PF06087.12 AET37625.1 - 0.032 13.1 0.0 0.049 12.5 0.0 1.2 1 0 0 1 1 1 0 Tyrosyl-DNA phosphodiesterase TPR_1 PF00515.28 AET37626.1 - 2.4e-19 68.3 2.5 6.5e-06 25.7 0.0 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 AET37626.1 - 1.1e-16 59.5 4.5 9.9e-05 22.2 0.1 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 AET37626.1 - 2.4e-12 47.3 1.2 2.2e-05 25.0 0.4 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 AET37626.1 - 2.5e-12 46.3 5.1 2.9e-06 26.9 0.1 5.0 3 1 3 6 6 6 3 TPR repeat TPR_8 PF13181.6 AET37626.1 - 3.5e-11 42.4 1.2 0.0086 16.2 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 AET37626.1 - 3.8e-11 42.8 0.9 0.0011 19.7 0.1 4.8 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 AET37626.1 - 9e-11 42.1 2.4 0.0072 16.8 0.3 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 AET37626.1 - 2.3e-09 37.3 0.6 0.00012 22.2 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 AET37626.1 - 4.5e-08 32.9 1.7 1.4 9.4 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_20 PF14561.6 AET37626.1 - 9.7e-08 32.2 0.5 0.0077 16.5 0.1 3.7 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 AET37626.1 - 0.00028 21.1 2.6 0.01 16.1 1.1 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat HGD-D PF06050.13 AET37626.1 - 0.00095 19.0 0.1 0.0064 16.3 0.0 2.1 1 1 1 2 2 2 1 2-hydroxyglutaryl-CoA dehydratase, D-component TPR_15 PF13429.6 AET37626.1 - 0.0028 16.9 1.0 0.52 9.5 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 AET37626.1 - 0.0051 16.8 0.1 17 5.7 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 AET37626.1 - 0.0087 16.6 0.4 42 5.1 0.0 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 AET37626.1 - 0.028 14.6 1.9 0.81 10.0 0.3 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 AET37626.1 - 0.03 14.8 2.2 0.11 13.0 0.1 2.6 2 1 1 3 3 2 0 Bacterial transcriptional activator domain Big_11 PF18200.1 AET37626.1 - 0.1 12.5 0.0 0.45 10.5 0.0 2.0 2 0 0 2 2 2 0 Bacterial Ig-like domain MIT PF04212.18 AET37626.1 - 0.12 12.5 0.1 23 5.1 0.0 3.2 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain DUF1641 PF07849.11 AET37626.1 - 0.15 11.9 0.2 0.28 11.1 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) TPR_10 PF13374.6 AET37626.1 - 6.5 6.8 7.2 6 6.9 0.6 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat Glyco_transf_34 PF05637.12 AET37627.1 - 5.1e-75 252.3 0.0 6e-75 252.0 0.0 1.0 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family P-mevalo_kinase PF04275.14 AET37627.1 - 0.069 13.1 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 Phosphomevalonate kinase ARID PF01388.21 AET37628.1 - 6.2e-13 49.2 0.1 6.2e-13 49.2 0.1 2.4 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain MTHFR PF02219.17 AET37629.1 - 6.1e-102 340.8 0.0 8.4e-102 340.3 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase RMI1_N PF08585.12 AET37630.1 - 4.3e-12 46.3 0.0 5.1e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 RecQ mediated genome instability protein Sybindin PF04099.12 AET37631.1 - 4e-38 130.6 0.2 7.8e-24 84.2 0.1 2.1 2 0 0 2 2 2 2 Sybindin-like family Sedlin_N PF04628.13 AET37631.1 - 1.7e-09 37.9 0.1 2.8e-09 37.2 0.1 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Serglycin PF04360.12 AET37631.1 - 0.28 11.1 1.5 0.47 10.4 1.5 1.3 1 0 0 1 1 1 0 Serglycin Chorion_2 PF03964.15 AET37631.1 - 7 7.6 16.4 0.49 11.2 10.3 1.9 1 1 1 2 2 2 0 Chorion family 2 DUF3020 PF11223.8 AET37632.1 - 5.8e-21 74.7 8.8 5.8e-21 74.7 8.8 7.9 7 1 0 7 7 7 1 Protein of unknown function (DUF3020) Cornifin PF02389.15 AET37632.1 - 0.028 14.6 2.2 0.21 11.8 1.1 2.6 2 1 0 2 2 2 0 Cornifin (SPRR) family zf-C2HE PF16278.5 AET37633.1 - 0.00046 20.6 0.8 12 6.5 0.0 3.6 3 0 0 3 3 3 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2 PF00096.26 AET37633.1 - 0.00082 19.7 2.0 0.00082 19.7 2.0 4.3 4 1 0 4 4 4 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AET37633.1 - 0.0015 18.9 11.6 0.0034 17.7 0.6 3.7 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 AET37633.1 - 0.0022 18.7 17.5 0.036 14.9 0.8 4.2 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 AET37633.1 - 0.022 15.4 0.9 0.13 12.9 0.0 2.6 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats PyrI_C PF02748.15 AET37633.1 - 0.15 12.0 1.4 0.57 10.1 0.4 2.2 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.8 AET37633.1 - 0.56 10.5 6.3 16 6.0 0.3 3.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding TPT PF03151.16 AET37634.1 - 1.3e-17 64.1 16.9 5.3e-17 62.1 16.9 1.8 1 1 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 AET37634.1 - 1.3e-10 41.0 12.2 1.1e-08 34.6 1.0 2.3 2 0 0 2 2 2 2 UAA transporter family Nuc_sug_transp PF04142.15 AET37634.1 - 4.4e-06 26.1 0.6 0.041 13.1 0.0 2.2 2 0 0 2 2 2 2 Nucleotide-sugar transporter EamA PF00892.20 AET37634.1 - 0.00019 21.6 34.1 0.0018 18.5 15.9 3.7 2 2 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 AET37634.1 - 0.00043 19.6 13.3 0.0012 18.1 13.3 1.7 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport TMEM234 PF10639.9 AET37634.1 - 0.0032 17.5 9.1 0.43 10.6 0.1 3.3 3 1 0 3 3 3 2 Putative transmembrane family 234 MRP-L28 PF09812.9 AET37635.1 - 5.1e-37 127.5 2.6 6.2e-37 127.2 2.6 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 FYRC PF05965.14 AET37635.1 - 0.12 12.6 0.3 0.29 11.3 0.1 1.8 2 0 0 2 2 2 0 F/Y rich C-terminus Ras PF00071.22 AET37636.1 - 9.7e-51 171.6 0.0 1.2e-50 171.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET37636.1 - 5.5e-17 62.1 0.0 8.5e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET37636.1 - 8e-09 35.2 0.1 9.7e-09 34.9 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 AET37636.1 - 2.7e-05 23.8 0.0 6.9e-05 22.5 0.0 1.5 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AET37636.1 - 0.0019 18.1 0.0 2.2 8.1 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Gly_transf_sug PF04488.15 AET37637.1 - 1.1e-13 51.7 0.0 2.7e-13 50.3 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Isochorismatase PF00857.20 AET37638.1 - 5.7e-22 78.7 0.0 9.2e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 Isochorismatase family NUC153 PF08159.12 AET37640.1 - 3.9e-11 42.6 3.9 7.1e-11 41.7 3.9 1.5 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 AET37640.1 - 0.0057 17.5 1.2 42 5.2 0.1 4.0 4 0 0 4 4 4 1 WD domain, G-beta repeat Ecl1 PF12855.7 AET37642.1 - 3e-08 35.0 0.1 3.8e-08 34.7 0.1 1.3 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins zf-MYND PF01753.18 AET37642.1 - 0.021 14.9 2.2 0.051 13.7 2.2 1.7 1 0 0 1 1 1 0 MYND finger SSL_OB PF09199.10 AET37642.1 - 0.12 12.7 0.0 3.7 7.9 0.0 2.2 2 0 0 2 2 2 0 Staphylococcal superantigen-like OB-fold domain zf-C2H2 PF00096.26 AET37643.1 - 1.3e-06 28.5 10.3 0.00041 20.7 0.5 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AET37643.1 - 2.4e-05 24.6 17.6 5.3e-05 23.5 1.9 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 AET37643.1 - 0.024 15.4 8.6 0.041 14.7 2.5 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger PDGF_N PF04692.13 AET37643.1 - 2.8 8.8 8.4 0.71 10.7 2.7 2.9 3 0 0 3 3 3 0 Platelet-derived growth factor, N terminal region EI24 PF07264.11 AET37644.1 - 0.81 9.9 6.7 5.8 7.1 6.7 2.3 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) TBPIP PF07106.13 AET37646.1 - 7.5e-28 96.3 2.2 9.1e-28 96.0 0.3 2.0 2 0 0 2 2 2 1 TBPIP/Hop2 winged helix domain TMPIT PF07851.13 AET37646.1 - 0.05 12.8 2.6 0.066 12.5 2.6 1.2 1 0 0 1 1 1 0 TMPIT-like protein Atg14 PF10186.9 AET37646.1 - 0.085 11.9 2.7 0.092 11.8 2.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CdvA PF18822.1 AET37646.1 - 0.13 12.0 7.6 0.25 11.2 3.6 2.6 2 1 1 3 3 3 0 CdvA-like coiled-coil domain PhaP_Bmeg PF09602.10 AET37646.1 - 0.21 11.5 8.4 2.7 7.9 0.2 2.5 2 1 1 3 3 3 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Seryl_tRNA_N PF02403.22 AET37646.1 - 0.67 10.2 11.4 0.08 13.2 5.5 2.5 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Phage_GP20 PF06810.11 AET37646.1 - 3.6 7.4 11.7 0.54 10.0 6.7 2.2 2 1 1 3 3 3 0 Phage minor structural protein GP20 DUF1279 PF06916.13 AET37647.1 - 1.5e-25 89.6 0.0 2.2e-25 89.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) AGA2 PF17366.2 AET37648.1 - 8.2e-20 70.3 8.6 1.2e-19 69.7 8.6 1.3 1 0 0 1 1 1 1 A-agglutinin-binding subunit Aga2 Ribosomal_L24e PF01246.20 AET37649.1 - 1.7e-29 101.8 0.2 1.7e-29 101.8 0.2 2.0 2 0 0 2 2 2 1 Ribosomal protein L24e DUF775 PF05603.12 AET37649.1 - 0.086 12.4 2.0 0.11 12.0 2.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) DDHD PF02862.17 AET37649.1 - 3.4 7.8 6.4 4.1 7.5 6.4 1.1 1 0 0 1 1 1 0 DDHD domain Ribosomal_L7Ae PF01248.26 AET37650.1 - 3.3e-24 84.5 0.1 3.6e-24 84.3 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF2838 PF10998.8 AET37651.1 - 4.9e-40 136.2 14.6 4.9e-40 136.2 14.6 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF2838) MbeD_MobD PF04899.12 AET37651.1 - 0.045 13.9 0.3 0.18 11.9 0.1 2.0 2 0 0 2 2 2 0 MbeD/MobD like PPR_2 PF13041.6 AET37652.1 - 6.6e-15 55.0 2.8 1.3e-09 38.0 0.3 3.9 3 2 2 5 5 5 2 PPR repeat family PPR_3 PF13812.6 AET37652.1 - 6.2e-07 29.4 1.2 0.00014 21.9 0.1 3.3 3 0 0 3 3 3 1 Pentatricopeptide repeat domain PPR PF01535.20 AET37652.1 - 8.6e-05 22.5 4.4 0.00023 21.2 0.1 4.0 5 0 0 5 5 5 1 PPR repeat PPR_1 PF12854.7 AET37652.1 - 0.00061 19.4 0.5 0.0084 15.8 0.1 2.7 2 0 0 2 2 2 1 PPR repeat PPR_long PF17177.4 AET37652.1 - 0.0032 16.9 3.4 0.024 14.0 0.1 2.9 2 1 1 3 3 3 1 Pentacotripeptide-repeat region of PRORP Cgr1 PF03879.14 AET37653.1 - 2.7e-34 117.8 30.2 3e-34 117.6 30.2 1.0 1 0 0 1 1 1 1 Cgr1 family Type_III_YscX PF09474.10 AET37653.1 - 0.018 15.3 1.8 0.024 14.9 1.8 1.2 1 0 0 1 1 1 0 Type III secretion system YscX (type_III_YscX) DUF2048 PF09752.9 AET37653.1 - 0.026 13.6 3.9 0.029 13.5 3.9 1.1 1 0 0 1 1 1 0 Abhydrolase domain containing 18 FapA PF03961.13 AET37653.1 - 0.4 9.2 12.2 0.42 9.2 12.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A MIOX PF05153.15 AET37654.1 - 8.9e-119 395.6 6.2 1.3e-118 395.1 6.2 1.2 1 0 0 1 1 1 1 Myo-inositol oxygenase HD PF01966.22 AET37654.1 - 0.016 15.4 1.8 0.44 10.8 0.2 3.0 1 1 0 2 2 2 0 HD domain UBD PF16455.5 AET37654.1 - 0.09 13.0 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-binding domain Glyco_hydro_63 PF03200.16 AET37655.1 - 3.3e-159 530.8 3.5 3.3e-159 530.8 3.5 2.3 2 1 0 2 2 2 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 AET37655.1 - 3.5e-60 203.9 0.0 5.7e-60 203.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain UBN_AB PF14075.6 AET37655.1 - 0.089 12.5 0.5 0.28 10.9 0.5 1.7 1 1 0 1 1 1 0 Ubinuclein conserved middle domain Trp_syntA PF00290.20 AET37656.1 - 7.9e-90 300.2 0.1 1.1e-89 299.7 0.1 1.2 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 AET37656.1 - 5.1e-48 164.0 0.5 9.3e-48 163.1 0.5 1.4 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Med3 PF11593.8 AET37657.1 - 1.8e-33 116.3 34.4 4.7e-29 101.8 10.2 2.5 1 1 1 2 2 2 2 Mediator complex subunit 3 fungal HOOK PF05622.12 AET37657.1 - 0.024 12.8 0.3 0.03 12.5 0.3 1.1 1 0 0 1 1 1 0 HOOK protein DUF3867 PF12983.7 AET37657.1 - 0.024 14.7 0.2 0.038 14.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3867) Formyl_trans_N PF00551.19 AET37659.1 - 3.8e-30 105.0 0.1 6.2e-30 104.3 0.1 1.3 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 AET37659.1 - 5.1e-05 23.5 0.0 0.00011 22.4 0.0 1.6 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain Recombinase PF07508.13 AET37659.1 - 0.18 12.2 0.0 0.44 11.0 0.0 1.6 1 0 0 1 1 1 0 Recombinase Acyltransferase PF01553.21 AET37660.1 - 8e-09 35.2 0.0 5.3e-08 32.6 0.0 2.3 2 1 0 2 2 2 1 Acyltransferase FYVE PF01363.21 AET37661.1 - 3.7e-14 52.6 6.3 6.9e-14 51.7 6.3 1.5 1 0 0 1 1 1 1 FYVE zinc finger MBD_C PF14048.6 AET37661.1 - 0.41 11.4 4.4 0.89 10.3 1.4 2.6 2 0 0 2 2 2 0 C-terminal domain of methyl-CpG binding protein 2 and 3 STT3 PF02516.14 AET37662.1 - 5.1e-149 497.3 40.6 1.1e-145 486.3 38.6 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit Haspin_kinase PF12330.8 AET37663.1 - 3.8e-82 276.2 5.1 3.8e-82 276.2 5.1 2.2 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase PF00069.25 AET37663.1 - 0.00033 20.1 0.0 0.00063 19.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET37663.1 - 0.11 11.8 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein tyrosine kinase Telomerase_RBD PF12009.8 AET37664.1 - 2e-30 105.6 1.6 4.6e-30 104.4 0.5 2.3 2 0 0 2 2 2 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 AET37664.1 - 3.7e-11 43.0 1.9 5.7e-07 29.3 0.1 3.5 3 0 0 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) AIP3 PF03915.13 AET37665.1 - 4.7e-137 457.4 10.7 4.7e-137 457.4 10.7 2.0 2 0 0 2 2 2 1 Actin interacting protein 3 FliL PF03748.14 AET37665.1 - 0.11 13.1 6.6 0.59 10.7 0.1 3.8 4 0 0 4 4 4 0 Flagellar basal body-associated protein FliL HSBP1 PF06825.12 AET37665.1 - 0.34 10.8 2.9 0.53 10.2 0.4 2.7 3 0 0 3 3 3 0 Heat shock factor binding protein 1 DUF1640 PF07798.11 AET37665.1 - 0.42 10.6 5.8 0.11 12.6 0.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1640) DUF4298 PF14131.6 AET37665.1 - 2.4 8.2 8.0 0.16 12.0 0.5 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4298) Mus7 PF09462.10 AET37666.1 - 1.5e-36 126.5 20.2 1.9e-24 86.5 6.1 2.6 2 1 1 3 3 3 2 Mus7/MMS22 family SPACA7 PF15307.6 AET37666.1 - 0.08 13.2 0.4 0.26 11.6 0.4 1.9 1 0 0 1 1 1 0 Sperm acrosome-associated protein 7 SANT_DAMP1_like PF16282.5 AET37667.1 - 6.6e-26 90.3 7.8 6.6e-26 90.3 7.8 2.4 2 0 0 2 2 2 1 SANT/Myb-like domain of DAMP1 DMAP1 PF05499.12 AET37667.1 - 0.0026 17.7 17.1 0.78 9.6 17.1 2.6 1 1 0 1 1 1 1 DNA methyltransferase 1-associated protein 1 (DMAP1) TFIIA PF03153.13 AET37667.1 - 0.19 11.7 17.0 0.014 15.4 12.1 1.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Cullin PF00888.22 AET37668.1 - 2.5e-141 472.3 10.5 2.5e-141 472.3 10.5 1.7 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 AET37668.1 - 8.8e-16 57.7 2.5 4e-15 55.6 2.5 2.3 1 0 0 1 1 1 1 Cullin protein neddylation domain RYDR_ITPR PF01365.21 AET37668.1 - 0.00052 19.5 1.2 0.0011 18.5 0.4 1.9 2 0 0 2 2 2 1 RIH domain DUF3212 PF11486.8 AET37668.1 - 0.17 11.9 2.4 0.23 11.5 0.1 2.5 4 0 0 4 4 4 0 Protein of unknown function (DUF3212) zf-CCCH PF00642.24 AET37669.1 - 2.9e-10 39.8 3.2 7.1e-10 38.6 3.2 1.7 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 AET37669.1 - 9.3e-09 35.0 8.0 1.9e-08 34.0 8.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AET37669.1 - 2.9e-07 30.2 8.9 2.9e-07 30.2 8.9 2.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AET37669.1 - 5.7e-07 29.4 11.1 1.2e-06 28.4 11.1 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 AET37669.1 - 7e-07 29.2 7.2 3e-06 27.1 4.5 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 AET37669.1 - 1.7e-06 27.8 11.8 1.7e-06 27.8 11.8 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf_CCCH_4 PF18345.1 AET37669.1 - 4.1e-06 26.7 5.6 4.1e-06 26.7 5.6 1.9 2 0 0 2 2 2 1 Zinc finger domain zf-RING_2 PF13639.6 AET37669.1 - 6.9e-06 26.3 11.8 7e-06 26.3 9.5 2.2 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 AET37669.1 - 8.7e-06 25.5 7.6 1.9e-05 24.4 7.6 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 AET37669.1 - 9.7e-06 25.6 6.5 9.7e-06 25.6 6.5 2.0 3 0 0 3 3 2 1 zinc RING finger of MSL2 zf-CCCH_4 PF18044.1 AET37669.1 - 0.00011 21.9 1.8 0.00031 20.5 1.8 1.8 1 0 0 1 1 1 1 CCCH-type zinc finger zf-C3HC4_4 PF15227.6 AET37669.1 - 0.011 15.8 9.7 0.011 15.8 9.7 2.2 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-CCCH_2 PF14608.6 AET37669.1 - 0.038 14.5 2.9 0.12 12.9 2.9 1.9 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-RING_6 PF14835.6 AET37669.1 - 0.083 12.8 1.4 0.16 11.9 1.4 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-P11 PF03854.14 AET37669.1 - 0.11 12.1 5.1 0.26 11.0 5.1 1.5 1 0 0 1 1 1 0 P-11 zinc finger zf-rbx1 PF12678.7 AET37669.1 - 0.68 10.3 10.4 0.59 10.5 7.8 2.3 2 1 1 3 3 3 0 RING-H2 zinc finger domain C1_2 PF03107.16 AET37669.1 - 7.4 7.0 13.5 5.8 7.3 7.9 2.7 2 1 1 3 3 2 0 C1 domain Pex24p PF06398.11 AET37670.1 - 2e-98 329.7 9.2 2.6e-98 329.4 9.2 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Ribosomal_L38e PF01781.18 AET37671.1 - 2.9e-26 91.4 4.1 3.2e-26 91.2 4.1 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family TFIIF_beta_N PF17683.1 AET37672.1 - 4.5e-38 131.0 6.0 1.2e-37 129.6 6.0 1.8 1 0 0 1 1 1 1 TFIIF, beta subunit N-terminus TFIIF_beta PF02270.15 AET37672.1 - 1.7e-27 95.3 1.9 3.3e-27 94.4 1.9 1.5 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain Tau95 PF09734.9 AET37672.1 - 0.0074 17.1 1.0 0.0074 17.1 1.0 2.4 1 1 1 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Prp18 PF02840.15 AET37673.1 - 3.6e-31 108.1 0.0 6.8e-31 107.2 0.0 1.4 1 1 0 1 1 1 1 Prp18 domain SRA1 PF07304.11 AET37673.1 - 0.077 12.8 0.2 0.82 9.5 0.2 2.1 1 1 1 2 2 2 0 Steroid receptor RNA activator (SRA1) CTP_transf_like PF01467.26 AET37674.1 - 2.2e-27 96.0 0.1 1.5e-20 73.8 0.0 2.2 2 0 0 2 2 2 2 Cytidylyltransferase-like DUF4258 PF14076.6 AET37674.1 - 0.06 13.7 0.1 0.61 10.5 0.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4258) HABP4_PAI-RBP1 PF04774.15 AET37675.1 - 0.00089 20.1 0.1 0.0012 19.7 0.1 1.3 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family DnaJ PF00226.31 AET37676.1 - 1.7e-25 88.9 3.9 3.1e-25 88.1 3.9 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 AET37676.1 - 1.5e-24 86.8 0.0 2.5e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 AET37676.1 - 2.4e-11 43.8 19.7 4.6e-11 42.9 19.7 1.5 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 AET37676.1 - 0.48 10.5 6.8 0.97 9.5 2.0 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cytochrom_c3_2 PF14537.6 AET37676.1 - 5.7 7.5 8.3 62 4.2 8.7 2.2 1 1 1 2 2 2 0 Cytochrome c3 Anti-TRAP PF15777.5 AET37676.1 - 7.3 6.6 15.8 0.46 10.5 1.4 3.1 2 1 1 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein DUF2781 PF10914.8 AET37677.1 - 9.4e-34 116.9 8.2 1.1e-33 116.8 8.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Acetyltransf_1 PF00583.25 AET37679.1 - 1.2e-13 51.4 0.0 1.4e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AET37679.1 - 8.6e-09 35.7 0.0 1.2e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AET37679.1 - 8.3e-07 29.0 0.0 1.1e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TPR_11 PF13414.6 AET37679.1 - 0.026 14.2 0.0 0.044 13.5 0.0 1.4 1 0 0 1 1 1 0 TPR repeat Acetyltransf_9 PF13527.7 AET37679.1 - 0.073 13.1 0.0 0.13 12.3 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain LSM PF01423.22 AET37680.1 - 7.9e-18 63.9 0.0 8.6e-18 63.8 0.0 1.0 1 0 0 1 1 1 1 LSM domain Mannitol_dh_C PF08125.13 AET37680.1 - 0.15 11.5 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 Mannitol dehydrogenase C-terminal domain Pyr_redox_2 PF07992.14 AET37681.1 - 3.1e-65 220.3 3.5 3.8e-65 220.0 3.5 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 AET37681.1 - 2e-42 143.9 0.1 6e-42 142.4 0.1 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 AET37681.1 - 5.2e-20 71.8 4.9 1.6e-17 63.8 0.5 3.0 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AET37681.1 - 1.5e-12 47.5 0.8 2.7e-05 24.3 0.1 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 AET37681.1 - 1.2e-11 44.7 2.5 4.2e-10 39.5 0.2 2.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 AET37681.1 - 1.3e-10 41.1 3.6 4.9e-07 29.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 AET37681.1 - 2.2e-09 36.9 7.8 4.9e-08 32.5 3.8 2.9 2 1 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 AET37681.1 - 4e-07 29.5 1.7 4e-07 29.5 1.7 2.2 2 0 0 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.19 AET37681.1 - 4.9e-07 29.3 3.9 0.012 14.9 0.1 3.3 2 1 0 2 2 2 2 FAD binding domain AlaDh_PNT_C PF01262.21 AET37681.1 - 5.9e-07 29.0 1.7 0.015 14.6 0.3 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 AET37681.1 - 1e-05 24.5 11.6 0.00024 20.0 1.0 3.9 3 1 1 4 4 4 2 HI0933-like protein DAO PF01266.24 AET37681.1 - 1.5e-05 24.8 10.2 0.1 12.2 0.1 4.1 3 1 1 4 4 4 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 AET37681.1 - 0.0004 19.6 1.8 2.3 7.3 0.0 3.2 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 AET37681.1 - 0.00083 18.7 1.5 0.00083 18.7 1.5 2.3 1 1 1 2 2 2 1 Thi4 family 3HCDH_N PF02737.18 AET37681.1 - 0.0016 18.3 0.2 0.0016 18.3 0.2 2.8 3 0 0 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XdhC_C PF13478.6 AET37681.1 - 0.019 15.5 0.0 6.6 7.3 0.0 2.6 2 0 0 2 2 2 0 XdhC Rossmann domain UDPG_MGDP_dh_N PF03721.14 AET37681.1 - 0.048 13.2 0.1 0.048 13.2 0.1 2.7 3 0 0 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Lycopene_cycl PF05834.12 AET37681.1 - 0.065 12.3 1.4 1.6 7.7 0.0 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein Trp_halogenase PF04820.14 AET37681.1 - 0.86 8.4 4.2 2.3 7.0 0.5 2.2 2 0 0 2 2 2 0 Tryptophan halogenase GATA PF00320.27 AET37682.1 - 1.1e-16 60.1 3.3 1.1e-16 60.1 3.3 2.1 2 0 0 2 2 2 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 AET37682.1 - 0.061 12.8 0.4 0.18 11.3 0.4 1.8 1 0 0 1 1 1 0 TFIIB zinc-binding Fcf2 PF08698.11 AET37683.1 - 1.9e-33 114.7 0.3 4.5e-33 113.5 0.3 1.6 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing RINT1_TIP1 PF04437.13 AET37684.1 - 0.0063 15.5 0.0 0.0086 15.0 0.0 1.2 1 0 0 1 1 1 1 RINT-1 / TIP-1 family Thioredoxin_11 PF18078.1 AET37684.1 - 0.088 12.9 0.6 0.088 12.9 0.6 1.7 2 0 0 2 2 2 0 Thioredoxin-like SNTX domain tRNA-synt_2d PF01409.20 AET37685.1 - 7e-91 304.0 0.0 9.8e-91 303.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 AET37685.1 - 2e-13 50.4 1.2 6.5e-13 48.8 0.1 2.4 3 0 0 3 3 3 1 PheRS DNA binding domain 3 PheRS_DBD2 PF18554.1 AET37685.1 - 4.3e-11 42.6 1.6 1.1e-10 41.3 1.6 1.8 1 0 0 1 1 1 1 PheRS DNA binding domain 2 tRNA_synthFbeta PF17759.1 AET37685.1 - 3.7e-08 33.1 0.0 1.5e-05 24.6 0.0 2.3 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 AET37685.1 - 3.3e-06 26.4 0.1 0.00015 21.0 0.0 2.7 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 AET37685.1 - 3.7e-05 23.8 0.0 7.1e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) PaaX PF07848.12 AET37685.1 - 0.093 13.0 0.0 4.1 7.7 0.0 3.0 3 0 0 3 3 3 0 PaaX-like protein CDC45 PF02724.14 AET37687.1 - 0.00053 18.4 7.7 0.00053 18.4 7.7 2.2 2 0 0 2 2 2 1 CDC45-like protein DNA_pol_phi PF04931.13 AET37687.1 - 4.9 5.1 20.8 11 4.0 20.8 1.5 1 0 0 1 1 1 0 DNA polymerase phi GCR1_C PF12550.8 AET37688.1 - 6.5e-11 42.4 1.6 4e-10 39.9 1.6 2.2 1 1 0 1 1 1 1 Transcriptional activator of glycolytic enzymes AAA_32 PF13654.6 AET37688.1 - 0.089 11.6 0.3 0.13 11.0 0.3 1.2 1 0 0 1 1 1 0 AAA domain DUF3835 PF12927.7 AET37689.1 - 2.5e-18 66.7 0.1 2.5e-18 66.7 0.1 5.2 5 0 0 5 5 5 2 Domain of unknown function (DUF3835) Prefoldin PF02996.17 AET37689.1 - 5.2e-09 36.0 0.4 1.4e-07 31.4 0.0 3.2 4 0 0 4 4 4 1 Prefoldin subunit EPL1 PF10513.9 AET37690.1 - 3.6e-21 76.2 3.4 3.6e-21 76.2 3.4 3.3 3 1 0 3 3 3 1 Enhancer of polycomb-like DUF3788 PF12663.7 AET37690.1 - 0.026 14.5 0.5 0.12 12.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3788) PGAP1 PF07819.13 AET37691.1 - 9.5e-94 313.4 0.0 1.5e-93 312.8 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 AET37691.1 - 0.00047 20.1 0.0 0.00074 19.4 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 AET37691.1 - 0.0023 18.6 0.0 0.0048 17.5 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 AET37691.1 - 0.0049 16.6 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF676 PF05057.14 AET37691.1 - 0.0095 15.5 0.0 0.023 14.2 0.0 1.6 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PAC1 PF16094.5 AET37691.1 - 0.018 14.2 0.1 0.035 13.3 0.1 1.4 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 Lipase_3 PF01764.25 AET37691.1 - 0.02 14.8 0.0 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_5 PF12695.7 AET37691.1 - 0.027 14.2 0.0 0.055 13.2 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AET37691.1 - 0.031 13.6 0.0 0.058 12.6 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF2974 PF11187.8 AET37691.1 - 0.071 12.7 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Esterase PF00756.20 AET37691.1 - 0.22 11.2 0.0 0.44 10.2 0.0 1.4 1 0 0 1 1 1 0 Putative esterase STE2 PF02116.15 AET37692.1 - 3.9e-86 288.8 26.0 4.8e-86 288.6 26.0 1.1 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR CybS PF05328.12 AET37693.1 - 1.3e-51 173.8 0.0 1.5e-51 173.6 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Sdh_cyt PF01127.22 AET37693.1 - 0.063 13.3 0.5 1.8 8.6 0.5 2.3 1 1 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Phage_holin_3_1 PF05106.12 AET37693.1 - 0.12 12.8 0.2 0.19 12.2 0.2 1.3 1 0 0 1 1 1 0 Phage holin family (Lysis protein S) Acyltransferase PF01553.21 AET37694.1 - 0.00066 19.3 0.2 0.002 17.8 0.0 1.8 2 0 0 2 2 2 1 Acyltransferase Acyltransf_C PF16076.5 AET37694.1 - 0.0019 18.2 0.9 0.0046 17.0 0.3 1.9 2 0 0 2 2 2 1 Acyltransferase C-terminus LRR_6 PF13516.6 AET37695.1 - 7.5e-07 28.7 17.6 6.4 7.1 0.0 8.3 9 0 0 9 9 9 5 Leucine Rich repeat LRR_4 PF12799.7 AET37695.1 - 8.8e-05 22.8 37.4 0.3 11.6 1.0 7.8 4 2 5 10 10 10 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 AET37695.1 - 0.0004 20.5 13.6 45 5.2 0.0 7.7 7 1 0 7 7 7 1 Leucine Rich Repeat LRR_8 PF13855.6 AET37695.1 - 0.014 15.1 26.5 8.6 6.2 4.0 6.7 4 2 2 6 6 6 0 Leucine rich repeat MBF1 PF08523.10 AET37696.1 - 5.8e-22 77.9 1.3 9.8e-22 77.2 1.3 1.4 1 0 0 1 1 1 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 AET37696.1 - 9.3e-10 38.4 0.1 1.6e-09 37.6 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 AET37696.1 - 0.00076 19.8 0.0 0.0019 18.5 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.7 AET37696.1 - 0.053 13.5 0.1 0.084 12.9 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain hSH3 PF14603.6 AET37696.1 - 0.085 13.3 0.1 0.17 12.3 0.1 1.5 1 0 0 1 1 1 0 Helically-extended SH3 domain TFIID-31kDa PF02291.15 AET37697.1 - 4.5e-49 165.6 0.0 5.1e-49 165.4 0.0 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Get5_bdg PF16843.5 AET37697.1 - 0.098 12.2 0.0 0.43 10.1 0.0 1.9 2 0 0 2 2 2 0 Binding domain to Get4 on Get5, Golgi to ER traffic protein Rtt102p PF09510.10 AET37697.1 - 0.17 12.1 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 Rtt102p-like transcription regulator protein ChAPs PF09295.10 AET37698.1 - 2.1e-166 553.8 0.0 2.8e-166 553.4 0.0 1.2 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) ANAPC3 PF12895.7 AET37698.1 - 0.054 13.7 0.5 4.7 7.5 0.1 3.2 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Glyco_hydro_32N PF00251.20 AET37699.1 - 6.8e-85 285.3 12.6 1e-84 284.7 12.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 AET37699.1 - 5.4e-14 52.5 0.4 9.3e-14 51.7 0.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal CBM39 PF15886.5 AET37699.1 - 0.033 14.1 0.0 0.11 12.5 0.0 1.8 1 0 0 1 1 1 0 Carbohydrate binding domain (family 32) DUF4369 PF14289.6 AET37699.1 - 0.037 14.5 0.6 0.22 12.1 0.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4369) Glyco_hydro_76 PF03663.14 AET37700.1 - 1.9e-151 504.7 9.5 2.2e-151 504.5 9.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 AET37700.1 - 0.5 9.4 8.6 1.8 7.6 0.3 3.0 1 1 1 2 2 2 0 Glycosyl Hydrolase Family 88 zf-C2H2_4 PF13894.6 AET37701.1 - 8.5e-06 26.2 15.7 0.0012 19.5 1.6 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.26 AET37701.1 - 0.00016 21.9 2.2 0.00016 21.9 2.2 3.9 3 1 0 3 3 3 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AET37701.1 - 0.0021 18.4 10.9 0.014 15.8 1.0 3.2 3 1 0 3 3 3 2 Zinc-finger double domain zf-H2C2_5 PF13909.6 AET37701.1 - 0.0048 16.6 1.3 0.0048 16.6 1.3 2.9 3 0 0 3 3 3 1 C2H2-type zinc-finger domain Peptidase_MA_2 PF13485.6 AET37702.1 - 0.023 14.4 0.1 0.06 13.0 0.0 1.6 2 0 0 2 2 2 0 Peptidase MA superfamily RGS PF00615.19 AET37702.1 - 0.093 13.0 0.4 0.59 10.4 0.1 2.2 2 0 0 2 2 2 0 Regulator of G protein signaling domain Leader_CPA1 PF08252.11 AET37703.1 - 8.9e-17 60.2 7.6 9.5e-17 60.1 7.6 1.0 1 0 0 1 1 1 1 arg-2/CPA1 leader peptide GATase PF00117.28 AET37704.1 - 6e-43 146.8 0.0 9.5e-43 146.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 AET37704.1 - 2.2e-42 143.9 0.0 3.3e-42 143.3 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.13 AET37704.1 - 8.4e-05 22.4 0.1 0.0044 16.8 0.1 2.9 2 1 0 2 2 2 1 Peptidase C26 RCC1 PF00415.18 AET37705.1 - 2.1e-13 50.7 3.1 1e-05 26.1 0.2 4.3 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 AET37705.1 - 3e-09 36.5 12.1 1.5e-07 31.0 0.4 3.6 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 AET37705.1 - 3e-07 30.6 0.2 2.1e-06 27.9 0.1 2.4 2 0 0 2 2 2 1 BTB/POZ domain FAM76 PF16046.5 AET37705.1 - 0.074 12.4 0.4 0.14 11.5 0.4 1.4 1 0 0 1 1 1 0 FAM76 protein SNF2_N PF00176.23 AET37706.1 - 7.3e-72 242.0 0.5 1.4e-71 241.0 0.5 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 AET37706.1 - 2.2e-37 127.6 2.7 2.2e-37 127.6 2.7 2.6 2 0 0 2 2 1 1 SLIDE HAND PF09110.11 AET37706.1 - 1.5e-32 112.7 2.7 1.5e-32 112.7 2.7 3.0 2 0 0 2 2 2 1 HAND Helicase_C PF00271.31 AET37706.1 - 9.6e-20 71.0 0.0 4e-19 69.0 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET37706.1 - 3e-12 46.9 0.0 2.2e-11 44.1 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AET37706.1 - 0.00017 21.4 0.0 0.00055 19.8 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Myb_DNA-binding PF00249.31 AET37706.1 - 0.00027 21.1 0.0 0.0024 18.0 0.0 2.6 2 0 0 2 2 2 1 Myb-like DNA-binding domain HDA2-3 PF11496.8 AET37706.1 - 0.0011 18.2 4.4 0.0039 16.4 0.0 3.4 3 1 0 4 4 4 1 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 AET37706.1 - 0.0028 16.9 0.2 0.006 15.8 0.2 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DEAD_2 PF06733.15 AET37706.1 - 0.041 13.5 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 DEAD_2 AAA_14 PF13173.6 AET37706.1 - 0.08 13.0 1.2 0.26 11.3 0.1 2.5 2 0 0 2 2 2 0 AAA domain Condensin2nSMC PF12422.8 AET37706.1 - 0.082 13.1 0.9 0.62 10.2 0.2 2.4 2 0 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit NYD-SP28_assoc PF14775.6 AET37706.1 - 0.1 12.7 0.5 0.43 10.7 0.5 2.2 1 0 0 1 1 1 0 Sperm tail C-terminal domain RNase_3_N PF18497.1 AET37707.1 - 2.4e-41 140.3 0.5 7.2e-41 138.7 0.5 1.9 1 0 0 1 1 1 1 Ribonuclease III N-terminal domain Ribonuclease_3 PF00636.26 AET37707.1 - 3e-17 63.2 0.0 1.3e-16 61.1 0.0 2.1 3 0 0 3 3 3 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 AET37707.1 - 3.8e-12 46.5 0.0 7.7e-12 45.5 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.26 AET37707.1 - 0.00011 22.9 0.5 0.00096 19.8 0.0 2.6 3 0 0 3 3 3 1 Double-stranded RNA binding motif DUF382 PF04037.13 AET37708.1 - 3.8e-51 172.5 0.1 1.2e-50 170.9 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.16 AET37708.1 - 2.9e-19 68.6 2.1 5.5e-19 67.8 2.1 1.5 1 0 0 1 1 1 1 PSP DUF1664 PF07889.12 AET37709.1 - 0.016 15.3 1.1 0.017 15.2 1.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF2034 PF10356.9 AET37710.1 - 3.8e-59 199.2 0.2 4.4e-59 199.0 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 AET37710.1 - 0.00057 19.9 0.1 0.031 14.3 0.0 2.1 2 0 0 2 2 2 2 Restriction endonuclease Mito_carr PF00153.27 AET37711.1 - 7.2e-28 96.4 6.6 4.6e-13 48.9 0.1 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein SART-1 PF03343.13 AET37712.1 - 7.8e-61 206.4 31.6 1.1e-59 202.7 31.6 2.3 1 1 0 1 1 1 1 SART-1 family DEAD PF00270.29 AET37712.1 - 0.023 14.5 0.1 0.064 13.0 0.1 1.7 1 0 0 1 1 1 0 DEAD/DEAH box helicase PB1 PF00564.24 AET37712.1 - 0.058 13.3 1.3 0.46 10.5 0.2 2.5 1 1 1 2 2 2 0 PB1 domain Arm-DNA-bind_2 PF12167.8 AET37712.1 - 0.41 10.6 1.9 1.9 8.5 0.4 2.7 2 0 0 2 2 2 0 Arm DNA-binding domain Nop PF01798.18 AET37713.1 - 1.1e-81 273.8 0.1 1.1e-81 273.8 0.1 2.5 3 0 0 3 3 3 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 AET37713.1 - 1e-18 67.5 3.2 1e-18 67.5 3.2 2.5 2 1 0 2 2 2 1 NOP5NT (NUC127) domain YL1 PF05764.13 AET37713.1 - 0.014 15.5 40.6 0.025 14.7 40.6 1.4 1 0 0 1 1 1 0 YL1 nuclear protein DUF4604 PF15377.6 AET37713.1 - 0.081 13.3 40.2 0.16 12.4 40.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) PPP4R2 PF09184.11 AET37713.1 - 1.8 8.1 31.6 3.2 7.3 31.6 1.4 1 0 0 1 1 1 0 PPP4R2 GAGA_bind PF06217.12 AET37713.1 - 4.2 7.6 23.9 10 6.3 23.9 1.7 1 0 0 1 1 1 0 GAGA binding protein-like family RR_TM4-6 PF06459.12 AET37713.1 - 4.5 7.0 33.5 8.1 6.2 33.5 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ribosomal_L18A PF01775.17 AET37715.1 - 8.8e-54 180.8 0.7 1.1e-53 180.4 0.7 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A NTP_transf_3 PF12804.7 AET37716.1 - 0.15 12.4 0.1 0.52 10.7 0.0 1.9 3 0 0 3 3 3 0 MobA-like NTP transferase domain Cation_efflux PF01545.21 AET37718.1 - 4e-56 189.9 3.9 6.7e-56 189.2 3.9 1.3 1 0 0 1 1 1 1 Cation efflux family DUF2157 PF09925.9 AET37718.1 - 0.15 11.8 2.3 7 6.4 0.4 2.6 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) SUN PF03856.13 AET37719.1 - 2e-85 286.2 18.0 2.4e-85 285.9 18.0 1.1 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) Bac_rhodopsin PF01036.18 AET37720.1 - 4.9e-40 137.5 16.6 6e-40 137.2 16.6 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein COX6B PF02297.17 AET37721.1 - 1.3e-22 79.8 3.2 1.7e-22 79.4 3.2 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb RabGAP-TBC PF00566.18 AET37722.1 - 1.7e-17 63.8 6.7 1.1e-16 61.1 3.7 2.5 2 1 0 2 2 2 1 Rab-GTPase-TBC domain WD40 PF00400.32 AET37723.1 - 7.3e-07 29.8 4.8 9.3 7.3 0.0 6.8 7 0 0 7 7 7 3 WD domain, G-beta repeat SDA1 PF05285.12 AET37723.1 - 6.8e-05 22.5 21.8 6.8e-05 22.5 21.8 2.1 2 0 0 2 2 2 1 SDA1 ABC_tran PF00005.27 AET37724.1 - 4.9e-18 66.0 0.0 1.4e-17 64.5 0.0 1.8 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AET37724.1 - 8.3e-10 38.9 1.2 0.0003 20.7 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AET37724.1 - 4.4e-05 23.0 0.1 0.19 11.1 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 AET37724.1 - 6.3e-05 23.6 0.3 9.3e-05 23.0 0.1 1.5 2 0 0 2 2 1 1 AAA domain RsgA_GTPase PF03193.16 AET37724.1 - 0.0012 18.8 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 AET37724.1 - 0.0013 18.5 0.4 0.0026 17.5 0.4 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 AET37724.1 - 0.004 16.9 1.4 0.0075 16.0 0.2 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AET37724.1 - 0.0071 16.6 0.7 0.037 14.3 0.1 2.0 2 0 0 2 2 2 1 AAA domain AAA_13 PF13166.6 AET37724.1 - 0.051 12.2 0.4 0.68 8.5 0.3 2.0 1 1 1 2 2 2 0 AAA domain Rad17 PF03215.15 AET37724.1 - 0.083 12.8 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain DUF3584 PF12128.8 AET37724.1 - 0.083 10.4 0.1 0.11 10.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Zeta_toxin PF06414.12 AET37724.1 - 0.1 11.9 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin MMR_HSR1 PF01926.23 AET37724.1 - 0.11 12.6 0.1 0.21 11.7 0.1 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 AET37724.1 - 0.12 12.4 0.1 0.22 11.5 0.1 1.3 1 0 0 1 1 1 0 Dynamin family AAA_18 PF13238.6 AET37724.1 - 0.15 12.6 0.1 0.36 11.4 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 AET37724.1 - 0.18 12.0 0.1 0.33 11.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain FA_hydroxylase PF04116.13 AET37725.1 - 2.5e-20 73.2 16.9 2.5e-20 73.2 16.9 2.5 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Pkinase PF00069.25 AET37726.1 - 8.2e-32 110.6 0.8 4.1e-31 108.3 0.8 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET37726.1 - 1.5e-22 80.1 0.0 2.2e-22 79.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 AET37726.1 - 2e-06 27.3 0.1 3.4e-06 26.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AET37726.1 - 1.2e-05 25.3 0.0 2e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 AET37726.1 - 0.00088 18.2 0.2 0.0013 17.6 0.2 1.2 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 AET37726.1 - 0.011 15.3 0.2 0.026 14.2 0.2 1.6 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 AET37726.1 - 0.013 15.1 0.1 0.032 13.8 0.1 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase Glyco_hydro_47 PF01532.20 AET37727.1 - 8.9e-87 291.9 1.4 1.1e-86 291.6 1.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Myb_DNA-bind_4 PF13837.6 AET37728.1 - 2.3e-05 24.7 0.2 5.2e-05 23.5 0.2 1.6 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DUF573 PF04504.14 AET37728.1 - 0.067 13.8 0.3 0.2 12.3 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function, DUF573 CysG_dimeriser PF10414.9 AET37728.1 - 0.13 12.0 0.7 18 5.2 0.0 2.4 2 0 0 2 2 2 0 Sirohaem synthase dimerisation region SHMT PF00464.19 AET37729.1 - 6.1e-205 680.4 0.0 7.1e-205 680.2 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 AET37729.1 - 3.8e-06 26.3 0.0 9.3e-06 25.0 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 AET37729.1 - 0.00061 19.2 0.0 0.00093 18.6 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase HSA PF07529.13 AET37729.1 - 0.0091 16.3 0.1 0.054 13.8 0.1 2.1 2 0 0 2 2 2 1 HSA DUF4559 PF15112.6 AET37729.1 - 0.015 15.0 0.2 0.029 14.1 0.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4559) FR47 PF08445.10 AET37729.1 - 0.12 12.4 0.0 0.59 10.1 0.0 2.0 2 0 0 2 2 2 0 FR47-like protein Baculo_DNA_bind PF04786.12 AET37729.1 - 0.13 11.6 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 ssDNA binding protein bZIP_1 PF00170.21 AET37730.1 - 2.5e-05 24.3 5.8 4.4e-05 23.5 5.8 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 AET37730.1 - 0.00043 20.3 7.2 0.00043 20.3 7.2 1.7 1 1 0 1 1 1 1 Basic region leucine zipper RNase_T PF00929.24 AET37731.1 - 9.5e-33 114.1 0.1 1.4e-32 113.5 0.1 1.3 1 0 0 1 1 1 1 Exonuclease DUF4148 PF13663.6 AET37731.1 - 0.65 10.2 0.0 0.65 10.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) PT-VENN PF04829.13 AET37731.1 - 2.9 8.0 9.6 5.7 7.1 9.6 1.4 1 0 0 1 1 1 0 Pre-toxin domain with VENN motif IMUP PF15761.5 AET37731.1 - 5.2 7.8 14.2 7.1 7.4 2.1 2.5 2 0 0 2 2 2 0 Immortalisation up-regulated protein Pkinase PF00069.25 AET37732.1 - 2.6e-57 194.2 0.1 3.9e-36 124.8 0.4 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AET37732.1 - 2.4e-24 86.0 0.2 1.4e-19 70.4 0.1 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 AET37732.1 - 7.5e-05 22.2 0.0 0.00049 19.5 0.1 2.0 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 AET37732.1 - 0.00017 21.0 0.1 0.00035 20.0 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Response_reg PF00072.24 AET37732.1 - 0.0018 18.4 0.0 0.0044 17.2 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain PAS PF00989.25 AET37732.1 - 0.015 15.3 0.5 0.056 13.4 0.0 2.2 2 0 0 2 2 2 0 PAS fold APH PF01636.23 AET37732.1 - 0.024 14.5 0.1 0.16 11.9 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.22 AET37732.1 - 0.06 12.9 0.2 0.21 11.2 0.1 1.8 1 1 1 2 2 2 0 RIO1 family SUIM_assoc PF16619.5 AET37732.1 - 0.067 13.3 12.6 0.31 11.2 12.6 2.2 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 FTA2 PF13095.6 AET37732.1 - 0.081 12.5 0.3 2.1 7.9 0.0 2.5 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PAS_9 PF13426.7 AET37732.1 - 0.12 12.6 0.0 0.34 11.2 0.0 1.7 1 0 0 1 1 1 0 PAS domain tRNA_synthFbeta PF17759.1 AET37733.1 - 6.8e-39 133.5 0.0 1.2e-38 132.7 0.0 1.4 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 AET37733.1 - 3e-30 104.3 0.5 9.5e-30 102.7 0.2 1.9 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 AET37733.1 - 2.1e-29 102.4 0.0 3.2e-29 101.8 0.0 1.3 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 AET37733.1 - 2.3e-16 59.8 0.0 8.6e-15 54.8 0.0 2.7 2 1 1 3 3 3 1 tRNA synthetase B5 domain Herpes_V23 PF01802.17 AET37733.1 - 0.039 13.4 0.2 0.076 12.4 0.2 1.4 1 0 0 1 1 1 0 Herpesvirus VP23 like capsid protein Ribosomal_L22e PF01776.17 AET37734.1 - 4.9e-40 136.3 0.3 6.4e-40 135.9 0.3 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Methyltransf_34 PF11312.8 AET37735.1 - 2.7e-90 302.7 0.0 3.4e-90 302.4 0.0 1.1 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase NMT1 PF09084.11 AET37735.1 - 0.22 11.5 0.0 0.91 9.4 0.0 1.8 2 0 0 2 2 2 0 NMT1/THI5 like Mob1_phocein PF03637.17 AET37736.1 - 5.8e-66 221.7 1.2 7.5e-66 221.3 1.2 1.1 1 0 0 1 1 1 1 Mob1/phocein family RNA_pol PF00940.19 AET37737.1 - 1.2e-178 594.3 0.0 1.6e-178 593.8 0.0 1.2 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 AET37737.1 - 8.6e-104 347.5 0.4 1.5e-103 346.8 0.4 1.4 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal Tubulin PF00091.25 AET37738.1 - 9.5e-68 228.3 0.0 1.6e-67 227.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 AET37738.1 - 9.1e-43 145.4 0.0 1.6e-42 144.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 AET37738.1 - 0.0016 18.1 0.0 0.003 17.3 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 AET37738.1 - 0.0044 16.3 0.0 0.0095 15.2 0.0 1.5 1 0 0 1 1 1 1 Tubulin like Misat_Tub_SegII PF10644.9 AET37738.1 - 0.024 14.9 0.0 0.071 13.4 0.0 1.8 1 1 0 1 1 1 0 Misato Segment II tubulin-like domain UPF0121 PF03661.13 AET37739.1 - 1.8e-10 40.7 18.3 2.6e-10 40.1 18.3 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) YbaJ PF10757.9 AET37739.1 - 0.058 13.9 0.5 0.19 12.3 0.5 1.8 1 0 0 1 1 1 0 Biofilm formation regulator YbaJ Ras PF00071.22 AET37740.1 - 2.8e-63 212.4 0.6 3.3e-63 212.1 0.6 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET37740.1 - 1.3e-36 125.4 0.2 2.2e-36 124.7 0.2 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET37740.1 - 3.7e-18 65.6 0.2 4.7e-18 65.2 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AET37740.1 - 3.9e-06 26.4 0.2 5.9e-06 25.8 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AET37740.1 - 7.8e-05 22.3 0.4 0.00024 20.7 0.4 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 AET37740.1 - 0.00016 21.7 0.1 0.00031 20.8 0.1 1.5 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AET37740.1 - 0.00045 20.2 0.5 0.13 12.2 0.0 2.4 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 AET37740.1 - 0.00049 19.6 0.1 0.00079 18.9 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.29 AET37740.1 - 0.011 16.2 0.0 0.2 12.1 0.0 2.2 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) Septin PF00735.18 AET37740.1 - 0.025 13.9 0.1 0.11 11.8 0.0 1.9 2 0 0 2 2 2 0 Septin AAA_16 PF13191.6 AET37740.1 - 0.026 14.9 0.0 0.035 14.5 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 AET37740.1 - 0.045 13.5 0.0 0.15 11.8 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain CENP-M PF11111.8 AET37740.1 - 0.054 12.7 0.0 0.076 12.2 0.0 1.2 1 0 0 1 1 1 0 Centromere protein M (CENP-M) AAA_22 PF13401.6 AET37740.1 - 0.072 13.4 0.0 0.2 11.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AET37740.1 - 0.089 13.3 0.1 0.15 12.6 0.1 1.6 1 1 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 AET37740.1 - 0.096 12.7 0.0 0.14 12.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TniB PF05621.11 AET37740.1 - 0.11 11.9 0.0 0.24 10.8 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein TMEM208_SND2 PF05620.11 AET37741.1 - 4.9e-37 127.3 0.1 5.3e-37 127.2 0.1 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 Actin PF00022.19 AET37742.1 - 7.8e-151 502.3 0.0 2.2e-150 500.8 0.0 1.6 1 1 0 1 1 1 1 Actin Sugar_tr PF00083.24 AET37743.1 - 1.6e-70 238.2 32.2 1.9e-70 238.0 32.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AET37743.1 - 9.1e-18 64.3 33.4 2.6e-16 59.5 19.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SPC22 PF04573.12 AET37744.1 - 1.3e-57 194.1 0.3 1.5e-57 193.9 0.3 1.0 1 0 0 1 1 1 1 Signal peptidase subunit rRNA_processing PF08524.11 AET37745.1 - 2.1e-27 96.0 25.0 2.6e-27 95.7 25.0 1.1 1 0 0 1 1 1 1 rRNA processing DUF3535 PF12054.8 AET37745.1 - 0.072 12.3 5.2 0.093 11.9 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3535) Membralin PF09746.9 AET37745.1 - 0.48 9.4 4.6 0.57 9.2 4.6 1.0 1 0 0 1 1 1 0 Tumour-associated protein GTP_EFTU PF00009.27 AET37746.1 - 1.1e-62 211.1 0.2 2.2e-62 210.1 0.2 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 AET37746.1 - 6.6e-35 119.5 0.1 1.4e-34 118.4 0.1 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 AET37746.1 - 1.6e-32 111.4 0.0 4e-32 110.1 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 AET37746.1 - 3.9e-24 84.5 0.0 9.4e-24 83.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 AET37746.1 - 5.3e-14 52.4 0.4 1.5e-13 50.9 0.4 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 AET37746.1 - 3.9e-07 30.0 0.0 9.7e-07 28.7 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain AvrPtoB_bdg PF16847.5 AET37746.1 - 0.0036 17.7 0.0 0.037 14.5 0.0 2.3 2 0 0 2 2 2 1 Avirulence AvrPtoB, BAK1-binding domain MMR_HSR1 PF01926.23 AET37746.1 - 0.0063 16.6 0.1 0.019 15.1 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Cu-oxidase_2 PF07731.14 AET37747.1 - 7.8e-41 139.0 14.2 8.6e-38 129.2 1.0 2.8 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 AET37747.1 - 9.9e-41 138.5 6.0 1.2e-36 125.3 2.0 3.1 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 AET37747.1 - 2.5e-34 118.7 6.7 3.9e-30 105.1 0.1 3.4 3 0 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.6 AET37747.1 - 0.014 15.5 0.0 2.4 8.3 0.0 3.7 4 1 0 4 4 4 0 Cupredoxin-like domain MazE_antitoxin PF04014.18 AET37747.1 - 0.03 14.2 0.0 17 5.5 0.0 3.2 3 0 0 3 3 3 0 Antidote-toxin recognition MazE, bacterial antitoxin DUF4971 PF16341.5 AET37747.1 - 0.15 11.9 0.1 4.2 7.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4971) Med14 PF08638.11 AET37748.1 - 2.9e-56 189.9 1.6 6.7e-56 188.7 0.2 2.3 2 0 0 2 2 2 1 Mediator complex subunit MED14 USP8_dimer PF08969.11 AET37749.1 - 2.1e-06 27.9 0.7 4e-06 27.0 0.2 1.8 2 0 0 2 2 2 1 USP8 dimerisation domain OTU PF02338.19 AET37750.1 - 2.2e-06 28.2 0.0 3.6e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease Fer2_3 PF13085.6 AET37750.1 - 0.13 12.3 0.0 0.32 11.0 0.0 1.7 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain zf-C2H2_jaz PF12171.8 AET37751.1 - 2e-10 40.7 6.9 4.8e-10 39.5 4.0 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 AET37751.1 - 0.00016 21.9 0.1 0.00029 21.1 0.1 1.4 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-AD PF07776.15 AET37751.1 - 0.015 15.5 0.0 0.035 14.3 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) zf-C2H2_4 PF13894.6 AET37751.1 - 0.038 14.8 1.6 0.073 13.9 0.7 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-U1 PF06220.12 AET37751.1 - 0.049 13.4 1.4 0.084 12.7 1.4 1.3 1 0 0 1 1 1 0 U1 zinc finger zf-C2HE PF16278.5 AET37751.1 - 0.078 13.4 1.1 0.16 12.4 0.6 2.0 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 AET37751.1 - 0.083 13.3 2.4 0.083 13.3 2.4 1.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Ribosomal_L16 PF00252.18 AET37752.1 - 7.4e-43 145.7 0.1 9.1e-43 145.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e PMM PF03332.13 AET37753.1 - 6.6e-111 369.4 0.4 7.5e-111 369.2 0.4 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 AET37753.1 - 7e-07 29.2 0.0 6.7e-06 26.0 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AET37753.1 - 0.098 12.9 0.0 0.2 11.9 0.0 1.7 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF1640 PF07798.11 AET37754.1 - 2.7e-53 180.6 8.8 3.3e-53 180.3 8.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) T2SSM PF04612.12 AET37754.1 - 0.15 12.1 3.5 0.11 12.6 1.5 1.7 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein M XhlA PF10779.9 AET37754.1 - 0.17 12.1 3.0 0.21 11.8 0.1 2.4 2 0 0 2 2 2 0 Haemolysin XhlA Uso1_p115_C PF04871.13 AET37754.1 - 0.19 12.1 5.6 0.11 12.9 1.8 2.0 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region GCN5L1 PF06320.13 AET37754.1 - 0.22 11.7 9.1 3.7 7.7 0.2 3.1 1 1 1 3 3 3 0 GCN5-like protein 1 (GCN5L1) FlaC_arch PF05377.11 AET37754.1 - 0.44 11.0 2.8 8.6 6.8 0.2 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Fib_alpha PF08702.10 AET37754.1 - 2.9 8.1 10.1 3.6 7.8 5.9 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family RCC1 PF00415.18 AET37755.1 - 1e-27 96.4 7.8 2.5e-07 31.2 0.1 5.8 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 AET37755.1 - 2.6e-15 55.8 10.1 3.4e-09 36.3 0.2 4.6 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat V-SNARE_C PF12352.8 AET37756.1 - 6.9e-07 29.5 4.1 6.9e-07 29.5 4.1 3.2 4 0 0 4 4 4 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 AET37756.1 - 0.0042 17.0 0.8 0.0042 17.0 0.8 2.6 2 1 0 2 2 2 1 Sec20 V_ATPase_I PF01496.19 AET37756.1 - 0.013 13.4 9.6 0.0041 15.1 3.6 1.9 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family DUF3829 PF12889.7 AET37756.1 - 0.015 14.8 1.2 0.018 14.5 0.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3829) BBP1_C PF15272.6 AET37756.1 - 0.016 15.1 2.8 0.016 15.1 2.8 1.9 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal DUF4407 PF14362.6 AET37756.1 - 0.021 14.2 1.5 0.027 13.8 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF489 PF04356.12 AET37756.1 - 0.024 14.6 1.3 0.66 10.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF489) DUF745 PF05335.13 AET37756.1 - 1.3 8.7 3.6 9 6.0 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF745) Exonuc_VII_L PF02601.15 AET37756.1 - 2.5 7.6 10.9 6 6.3 10.9 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit Syntaxin-6_N PF09177.11 AET37756.1 - 2.7 8.6 7.1 7.5 7.2 0.3 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DEP PF00610.21 AET37758.1 - 1.4e-12 47.5 0.0 3.3e-12 46.3 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FCH PF00611.23 AET37758.1 - 3.1e-10 40.2 1.7 2.2e-09 37.5 0.0 2.7 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain RhoGAP PF00620.27 AET37758.1 - 1.7e-09 37.7 1.4 3.4e-09 36.7 0.1 2.2 2 0 0 2 2 2 1 RhoGAP domain TFIIA_gamma_N PF02268.16 AET37758.1 - 0.1 12.6 0.1 1.9 8.6 0.0 2.7 3 0 0 3 3 3 0 Transcription initiation factor IIA, gamma subunit, helical domain Rdx PF10262.9 AET37759.1 - 1.2e-27 95.9 0.0 1.6e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 Rdx family Lectin_leg-like PF03388.13 AET37760.1 - 2.1e-39 135.2 0.1 3.1e-39 134.7 0.1 1.1 1 0 0 1 1 1 1 Legume-like lectin family DUF5013 PF16405.5 AET37760.1 - 0.0075 16.5 0.0 0.018 15.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5013) Bact_lectin PF18483.1 AET37760.1 - 0.0092 16.0 0.3 0.016 15.3 0.3 1.5 1 1 0 1 1 1 1 Bacterial lectin CRC_subunit PF08624.10 AET37761.1 - 1.2e-41 142.3 0.1 2.1e-41 141.5 0.1 1.4 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit GFO_IDH_MocA PF01408.22 AET37762.1 - 1.2e-18 68.1 0.1 1.9e-18 67.4 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 AET37762.1 - 7.9e-09 35.5 0.0 1.3e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain F420_oxidored PF03807.17 AET37762.1 - 0.044 14.4 0.1 0.089 13.4 0.1 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent THF_DHG_CYH PF00763.23 AET37762.1 - 0.093 13.0 0.1 0.25 11.6 0.0 1.7 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain DCP1 PF06058.13 AET37763.1 - 7.1e-26 90.4 0.1 4.5e-25 87.8 0.1 2.1 1 1 0 1 1 1 1 Dcp1-like decapping family Spt20 PF12090.8 AET37764.1 - 2.9e-73 246.4 14.3 2.9e-73 246.4 14.3 3.3 3 0 0 3 3 3 1 Spt20 family Ribosomal_L44 PF00935.19 AET37764.1 - 0.056 13.9 2.8 0.27 11.7 2.8 2.2 1 0 0 1 1 1 0 Ribosomal protein L44 PEX11 PF05648.14 AET37765.1 - 8.6e-63 211.8 0.5 9.8e-63 211.6 0.5 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Sld5 PF05916.11 AET37766.1 - 1.8e-16 60.5 0.0 2.3e-16 60.2 0.0 1.1 1 0 0 1 1 1 1 GINS complex protein TPR_2 PF07719.17 AET37767.1 - 1.3e-25 87.4 28.3 0.0032 17.5 0.1 14.9 15 1 1 16 16 16 7 Tetratricopeptide repeat TPR_12 PF13424.6 AET37767.1 - 9e-23 80.4 16.3 1.5e-05 25.1 0.1 9.7 9 2 3 12 12 12 7 Tetratricopeptide repeat TPR_1 PF00515.28 AET37767.1 - 4.4e-22 76.9 27.3 0.00058 19.6 0.0 13.2 15 0 0 15 15 15 7 Tetratricopeptide repeat TPR_16 PF13432.6 AET37767.1 - 1.5e-18 67.1 0.1 0.00033 21.2 0.0 7.9 5 3 3 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 AET37767.1 - 3.5e-14 52.3 15.5 0.16 12.9 0.0 12.3 12 2 2 14 14 13 3 Tetratricopeptide repeat TPR_19 PF14559.6 AET37767.1 - 2.7e-11 43.8 17.1 0.0013 19.2 0.1 9.5 8 2 3 11 11 11 3 Tetratricopeptide repeat TPR_8 PF13181.6 AET37767.1 - 2e-10 40.0 31.0 0.11 12.8 0.0 13.9 16 0 0 16 16 14 3 Tetratricopeptide repeat ANAPC3 PF12895.7 AET37767.1 - 4.8e-09 36.3 15.5 1.1e-05 25.6 0.0 6.9 8 1 1 9 9 9 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 AET37767.1 - 1.6e-08 34.2 9.9 0.1 12.5 0.0 8.7 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_6 PF13174.6 AET37767.1 - 1.6e-08 34.6 25.7 0.21 12.3 0.0 12.9 13 1 0 13 13 13 2 Tetratricopeptide repeat TPR_11 PF13414.6 AET37767.1 - 1.6e-06 27.7 12.6 6.8 6.5 0.0 9.2 9 0 0 9 9 9 2 TPR repeat TPR_17 PF13431.6 AET37767.1 - 1.8e-05 24.8 7.3 0.98 9.9 0.0 9.4 11 0 0 11 11 10 1 Tetratricopeptide repeat PPR PF01535.20 AET37767.1 - 0.085 13.1 2.0 38 4.8 0.0 5.3 6 0 0 6 6 6 0 PPR repeat TPR_MalT PF17874.1 AET37767.1 - 0.088 12.2 10.4 0.64 9.3 0.0 4.6 3 2 1 4 4 4 0 MalT-like TPR region RRM_1 PF00076.22 AET37768.1 - 0.0002 21.1 0.0 0.00042 20.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) nsp8 PF08717.10 AET37768.1 - 0.043 13.7 0.7 0.27 11.1 0.3 2.2 2 0 0 2 2 2 0 nsp8 replicase DUF2889 PF11136.8 AET37768.1 - 0.18 12.1 0.2 0.75 10.1 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2889) DMRL_synthase PF00885.19 AET37769.1 - 8.7e-51 171.5 0.1 1e-50 171.2 0.1 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase Hist_deacetyl PF00850.19 AET37770.1 - 8.3e-84 281.7 0.1 1.7e-83 280.7 0.0 1.5 2 0 0 2 2 2 1 Histone deacetylase domain DnaJ PF00226.31 AET37771.1 - 0.0017 18.4 0.1 0.0035 17.4 0.1 1.6 1 0 0 1 1 1 1 DnaJ domain Pesticin PF16754.5 AET37771.1 - 0.0043 17.0 0.5 0.079 12.9 0.1 2.1 1 1 1 2 2 2 1 Bacterial toxin homologue of phage lysozyme, C-term Pam16 PF03656.13 AET37771.1 - 0.074 13.1 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 Pam16 Mtc PF03820.17 AET37772.1 - 0.36 9.8 7.5 0.53 9.3 7.5 1.3 1 0 0 1 1 1 0 Tricarboxylate carrier RIFIN PF02009.16 AET37772.1 - 0.68 9.8 11.7 0.023 14.6 0.7 2.0 1 1 1 2 2 2 0 Rifin DHHC PF01529.20 AET37773.1 - 6e-34 117.0 11.5 6e-34 117.0 11.5 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase KH_6 PF15985.5 AET37774.1 - 4.4e-13 49.4 0.0 7.7e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 AET37774.1 - 1.5e-08 34.5 0.0 2.7e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain E1_UFD PF09358.10 AET37774.1 - 0.0045 17.7 0.0 0.0085 16.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin fold domain Syja_N PF02383.18 AET37775.1 - 6.1e-77 259.1 0.1 6.1e-77 259.1 0.1 2.8 3 1 0 3 3 3 1 SacI homology domain DUF3533 PF12051.8 AET37776.1 - 1.7e-103 346.5 8.4 1.9e-103 346.3 8.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) CDC50 PF03381.15 AET37777.1 - 4.7e-81 272.4 0.0 6.5e-81 271.9 0.0 1.2 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Phage_holin_5_2 PF16079.5 AET37777.1 - 0.089 13.1 4.8 0.87 10.0 0.3 2.3 2 0 0 2 2 2 0 Phage holin family Hol44, in holin superfamily V Aminotran_3 PF00202.21 AET37778.1 - 1.8e-117 392.4 0.0 2.2e-117 392.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III KRE1 PF17056.5 AET37779.1 - 5.3e-23 80.5 3.5 5.3e-23 80.5 3.5 3.0 2 1 1 3 3 3 2 Killer toxin-resistance protein 1 Na_Ca_ex PF01699.24 AET37780.1 - 6.3e-19 68.4 38.5 1.1e-15 58.0 13.0 3.4 4 1 0 4 4 4 2 Sodium/calcium exchanger protein YccF PF03733.13 AET37780.1 - 1.7e-12 47.8 3.8 1.7e-12 47.8 3.8 5.4 6 1 0 6 6 6 1 Inner membrane component domain PepSY_TM PF03929.16 AET37780.1 - 0.0045 16.7 0.1 0.31 10.7 0.1 2.4 2 0 0 2 2 2 1 PepSY-associated TM region DUF4834 PF16118.5 AET37780.1 - 0.063 14.2 0.8 0.063 14.2 0.8 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Spt20 PF12090.8 AET37780.1 - 0.12 12.0 10.9 0.21 11.2 10.9 1.3 1 0 0 1 1 1 0 Spt20 family Ctr PF04145.15 AET37780.1 - 0.28 11.8 0.0 0.28 11.8 0.0 3.4 4 0 0 4 4 4 0 Ctr copper transporter family CHD5 PF04420.14 AET37780.1 - 0.73 9.7 3.6 19 5.1 1.2 2.7 2 0 0 2 2 2 0 CHD5-like protein TFIIA PF03153.13 AET37780.1 - 8.8 6.2 13.0 16 5.4 13.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit IF4E PF01652.18 AET37781.1 - 2.5e-53 180.1 0.1 3.8e-53 179.5 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Toprim_Crpt PF13342.6 AET37781.1 - 0.081 12.9 0.2 0.15 12.0 0.2 1.4 1 0 0 1 1 1 0 C-terminal repeat of topoisomerase Hydrolase_4 PF12146.8 AET37782.1 - 5.2e-15 55.4 0.0 2.6e-08 33.4 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AET37782.1 - 3.4e-10 40.0 0.1 1.2e-06 28.4 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 AET37782.1 - 1.4e-05 24.7 0.0 3.6e-05 23.3 0.0 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.13 AET37782.1 - 0.0078 15.9 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) BAAT_C PF08840.11 AET37782.1 - 0.043 13.7 0.0 0.66 9.9 0.0 2.4 2 1 1 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF818 PF05677.12 AET37782.1 - 0.13 11.2 0.3 0.19 10.6 0.3 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Zn_ribbon_17 PF17120.5 AET37783.1 - 2.1e-09 36.8 5.9 4.1e-09 35.9 5.9 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 AET37783.1 - 4.2e-09 36.9 11.5 0.00053 20.7 0.0 6.1 6 0 0 6 6 6 2 WD domain, G-beta repeat zf-rbx1 PF12678.7 AET37783.1 - 0.22 11.8 9.9 0.69 10.2 9.9 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_2 PF13639.6 AET37783.1 - 0.23 11.8 11.8 0.042 14.2 7.9 1.9 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4 PF00097.25 AET37783.1 - 1.6 8.6 8.6 0.49 10.3 3.5 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) MFS_1 PF07690.16 AET37784.1 - 1.3e-20 73.6 39.0 1.9e-12 46.8 19.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2721 PF11026.8 AET37784.1 - 3.5 7.5 5.8 6.7 6.6 2.8 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) WD40 PF00400.32 AET37785.1 - 2.1e-26 91.6 16.7 7.7e-06 26.6 0.1 6.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET37785.1 - 1.7e-16 60.3 0.5 0.088 13.1 0.0 6.0 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AET37785.1 - 5.4e-06 26.4 2.7 0.0012 18.8 1.0 3.7 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 AET37785.1 - 0.001 18.1 1.6 0.7 8.8 0.0 3.9 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein 6PF2K PF01591.18 AET37786.1 - 1.6e-47 161.7 0.2 2.5e-47 161.0 0.2 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.6 AET37786.1 - 0.00013 22.2 0.0 0.00021 21.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 AET37786.1 - 0.01 15.3 0.0 0.022 14.2 0.0 1.6 1 1 0 1 1 1 0 Chromatin associated protein KTI12 AAA_18 PF13238.6 AET37786.1 - 0.023 15.2 0.1 0.047 14.2 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AET37786.1 - 0.13 12.5 0.0 0.34 11.2 0.0 1.9 1 1 0 1 1 1 0 AAA domain Med7 PF05983.11 AET37787.1 - 9.6e-61 205.2 0.5 1.1e-60 205.0 0.5 1.0 1 0 0 1 1 1 1 MED7 protein SPECT1 PF18680.1 AET37787.1 - 0.019 14.6 1.1 2.1 8.0 0.2 2.1 2 0 0 2 2 2 0 Plasmodium host cell traversal SPECT1 zf-rbx1 PF12678.7 AET37788.1 - 2.3e-23 82.3 13.4 3.9e-23 81.5 13.4 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 AET37788.1 - 9e-17 60.9 10.7 1.1e-16 60.6 10.7 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 AET37788.1 - 4.4e-06 26.9 14.0 0.00018 21.8 14.0 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 AET37788.1 - 0.0003 20.5 3.8 0.0003 20.5 3.8 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AET37788.1 - 0.0016 18.2 12.0 0.0081 16.0 12.0 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 AET37788.1 - 0.0023 17.6 0.9 0.0023 17.6 0.9 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-HC5HC2H PF13771.6 AET37788.1 - 0.17 12.1 9.9 13 6.1 9.9 2.1 1 1 0 1 1 1 0 PHD-like zinc-binding domain zf-RING_UBOX PF13445.6 AET37788.1 - 0.67 10.0 8.8 3.2 7.9 8.8 2.0 1 1 0 1 1 1 0 RING-type zinc-finger FANCL_C PF11793.8 AET37788.1 - 1.7 8.9 10.1 7.9 6.7 10.4 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 AET37788.1 - 3.9 7.2 14.5 0.46 10.1 4.4 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 AET37788.1 - 6.4 6.8 11.4 31 4.7 11.4 2.1 1 1 0 1 1 1 0 zinc-RING finger domain PDT PF00800.18 AET37789.1 - 8.4e-49 165.9 0.0 1.1e-48 165.5 0.0 1.1 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 AET37789.1 - 0.00032 20.4 0.0 0.00069 19.3 0.0 1.6 1 0 0 1 1 1 1 ACT domain ATP11 PF06644.11 AET37790.1 - 2.3e-90 303.1 2.3 2.7e-90 302.8 2.3 1.0 1 0 0 1 1 1 1 ATP11 protein Nup54_57_C PF18570.1 AET37790.1 - 0.89 9.2 9.2 1 9.0 1.8 3.5 3 0 0 3 3 3 0 NUP57/Nup54 C-terminal domain TPR_8 PF13181.6 AET37791.1 - 8.9e-09 34.9 4.7 0.048 13.9 0.1 6.0 7 1 1 8 8 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 AET37791.1 - 5.9e-08 32.9 0.6 0.67 10.9 0.0 5.6 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 AET37791.1 - 7.8e-07 28.7 5.0 0.0037 17.3 0.0 6.2 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 AET37791.1 - 5.2e-06 26.9 0.6 0.14 12.7 0.0 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 AET37791.1 - 3.5e-05 24.0 1.5 0.053 13.8 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 AET37791.1 - 4.5e-05 23.1 2.2 0.13 12.1 0.0 5.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 AET37791.1 - 0.0004 20.2 0.8 0.52 10.5 0.0 4.0 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 AET37791.1 - 0.00061 19.9 1.0 1 9.6 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 AET37791.1 - 0.0055 17.3 2.5 73 4.1 0.0 4.7 3 2 1 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 AET37791.1 - 0.0062 16.8 4.1 0.38 11.3 0.0 4.8 6 1 0 6 6 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 AET37791.1 - 0.017 14.8 0.0 8.2 6.2 0.0 4.5 4 1 1 5 5 5 0 TPR repeat TPR_10 PF13374.6 AET37791.1 - 0.021 14.7 4.4 0.079 12.9 0.0 4.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_15 PF13429.6 AET37791.1 - 0.087 12.0 0.4 3.4 6.8 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat RPN7 PF10602.9 AET37791.1 - 0.14 11.9 0.3 23 4.6 0.0 2.8 3 0 0 3 3 3 0 26S proteasome subunit RPN7 ANAPC3 PF12895.7 AET37791.1 - 0.37 11.1 1.7 11 6.3 0.3 2.9 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 RPA_C PF08784.11 AET37792.1 - 6.6e-09 36.4 1.4 1.3e-08 35.5 0.0 2.1 3 0 0 3 3 3 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 AET37792.1 - 3.4e-07 30.1 0.3 5.9e-07 29.4 0.3 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Barwin PF00967.17 AET37792.1 - 0.029 14.2 0.1 0.054 13.3 0.1 1.6 1 0 0 1 1 1 0 Barwin family CDC24_OB3 PF17244.2 AET37792.1 - 0.065 12.9 0.4 0.16 11.6 0.0 1.7 2 0 0 2 2 2 0 Cell division control protein 24, OB domain 3 Glyco_hydro_72 PF03198.14 AET37793.1 - 6.6e-134 446.1 0.8 9e-134 445.7 0.8 1.2 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 AET37793.1 - 0.0049 16.3 0.2 0.049 13.1 0.2 2.5 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Thymosin PF01290.20 AET37793.1 - 0.094 12.5 0.5 0.21 11.4 0.5 1.6 1 0 0 1 1 1 0 Thymosin beta-4 family DUF5376 PF17346.2 AET37793.1 - 0.12 12.7 0.7 0.31 11.4 0.7 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5376) F-box-like PF12937.7 AET37794.1 - 6.8e-07 29.1 2.3 6.8e-07 29.1 2.3 2.4 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 AET37794.1 - 2.3e-05 24.1 6.0 9.9e-05 22.1 3.9 2.6 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 AET37794.1 - 0.00021 21.2 0.6 0.00055 19.8 0.6 1.7 1 0 0 1 1 1 1 F-box RGS12_usC PF16612.5 AET37794.1 - 0.13 12.7 0.7 0.77 10.2 0.1 2.2 2 0 0 2 2 2 0 C-terminal unstructured region of RGS12 zf-DNL PF05180.12 AET37795.1 - 1e-31 108.7 2.2 1.6e-31 108.0 2.2 1.3 1 0 0 1 1 1 1 DNL zinc finger UPF0167 PF03691.14 AET37795.1 - 0.065 13.0 0.0 0.079 12.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) zf-ZPR1 PF03367.13 AET37795.1 - 0.097 12.5 1.5 0.18 11.7 1.5 1.7 1 1 0 1 1 1 0 ZPR1 zinc-finger domain WW_FCH_linker PF16623.5 AET37795.1 - 0.12 13.1 3.5 12 6.8 0.0 2.6 3 0 0 3 3 3 0 Unstructured linker region between on GAS7 protein PHD PF00628.29 AET37795.1 - 0.19 11.7 2.8 3.3 7.7 0.9 2.6 2 1 0 2 2 2 0 PHD-finger zinc_ribbon_4 PF13717.6 AET37795.1 - 0.98 9.4 5.1 13 5.8 5.6 2.3 2 1 1 3 3 3 0 zinc-ribbon domain CorA PF01544.18 AET37797.1 - 3e-40 138.4 0.1 1.3e-22 80.5 0.0 2.2 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein Hydin_ADK PF17213.3 AET37797.1 - 1.4 9.1 3.8 1.1 9.5 0.1 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain UPF0220 PF05255.11 AET37798.1 - 9e-67 223.8 2.2 1e-66 223.6 2.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) Pkinase PF00069.25 AET37799.1 - 5.3e-58 196.5 0.0 6.5e-58 196.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET37799.1 - 1.5e-29 103.1 0.0 2e-29 102.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET37799.1 - 3.3e-07 29.9 0.0 4.8e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AET37799.1 - 0.00034 20.6 0.0 0.00059 19.8 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 AET37799.1 - 0.0017 17.8 0.0 0.0025 17.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 AET37799.1 - 0.028 14.0 0.0 0.044 13.4 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Ribosomal_S11 PF00411.19 AET37800.1 - 1.8e-06 28.3 0.0 3e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S11 Dicer_dimer PF03368.14 AET37800.1 - 0.044 14.0 0.0 0.074 13.2 0.0 1.3 1 0 0 1 1 1 0 Dicer dimerisation domain Ribosomal_L23eN PF03939.13 AET37801.1 - 2.6e-18 65.9 9.9 2.6e-18 65.9 9.9 2.0 2 1 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 AET37801.1 - 3.4e-16 59.4 4.0 3.4e-16 59.4 4.0 2.9 2 2 0 2 2 2 1 Ribosomal protein L23 DUF983 PF06170.12 AET37802.1 - 2.5 8.6 9.3 1.4 9.4 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF983) Ldh_1_N PF00056.23 AET37803.1 - 2.2e-39 134.7 0.5 3.7e-39 134.0 0.5 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 AET37803.1 - 4.3e-35 121.1 0.0 9.3e-35 120.0 0.0 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain TRM13 PF05206.14 AET37804.1 - 3.4e-79 266.0 0.0 7.8e-79 264.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase TRM13 zf-TRM13_CCCH PF11722.8 AET37804.1 - 3.5e-11 42.6 2.6 3.5e-11 42.6 2.6 2.2 2 0 0 2 2 2 1 CCCH zinc finger in TRM13 protein zf-U11-48K PF05253.12 AET37804.1 - 2.1e-10 40.3 6.0 1e-09 38.1 1.4 2.6 2 0 0 2 2 2 1 U11-48K-like CHHC zinc finger Methyltransf_32 PF13679.6 AET37804.1 - 0.0044 17.0 0.4 0.014 15.4 0.4 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ras PF00071.22 AET37805.1 - 2.5e-31 108.5 0.1 6.2e-27 94.2 0.1 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 AET37805.1 - 8e-18 64.8 0.0 6.1e-13 49.1 0.0 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET37805.1 - 6.2e-08 32.3 0.3 3.5e-07 29.9 0.1 2.1 3 0 0 3 3 3 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AET37805.1 - 0.0036 16.7 0.7 0.06 12.7 0.2 2.4 2 1 0 2 2 2 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AET37805.1 - 0.0074 15.8 0.1 0.014 14.9 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 AET37805.1 - 0.017 14.6 0.0 0.035 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 AET37805.1 - 0.063 13.6 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 AET37805.1 - 0.074 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) UPF0020 PF01170.18 AET37806.1 - 1.2e-10 41.4 0.0 2.7e-09 37.0 0.0 2.4 2 1 0 2 2 2 1 Putative RNA methylase family UPF0020 MethyltransfD12 PF02086.15 AET37806.1 - 0.012 15.3 0.6 5.5 6.6 0.1 2.8 2 1 1 3 3 3 0 D12 class N6 adenine-specific DNA methyltransferase N6_Mtase PF02384.16 AET37806.1 - 0.013 14.8 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 N-6 DNA Methylase Cons_hypoth95 PF03602.15 AET37806.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 RRM_1 PF00076.22 AET37807.1 - 2.2e-34 117.1 0.1 4.7e-17 61.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AET37807.1 - 1.2e-10 41.4 0.1 8.2e-05 22.7 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif ESAG1 PF03238.13 AET37807.1 - 0.081 12.4 1.1 0.16 11.4 1.1 1.4 1 0 0 1 1 1 0 ESAG protein RRM_3 PF08777.11 AET37807.1 - 0.21 11.7 1.0 0.89 9.6 0.0 2.4 3 0 0 3 3 3 0 RNA binding motif TFIIA PF03153.13 AET37807.1 - 1 9.3 40.1 2.3 8.1 14.3 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Nramp PF01566.18 AET37808.1 - 5.3e-82 275.6 25.2 3.3e-80 269.8 25.2 2.2 1 1 0 1 1 1 1 Natural resistance-associated macrophage protein PBP1_TM PF14812.6 AET37808.1 - 0.012 15.9 0.1 0.029 14.8 0.1 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ribosomal_S19e PF01090.19 AET37809.1 - 3.8e-54 182.1 0.0 4.3e-54 181.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Ribosomal_L18 PF17135.4 AET37810.1 - 3.3e-84 281.0 2.9 3.6e-84 280.8 2.9 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 AET37810.1 - 0.0071 17.0 0.6 0.0071 17.0 0.6 2.2 2 1 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Nudc_N PF14050.6 AET37810.1 - 0.12 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 N-terminal conserved domain of Nudc. MFS_1 PF07690.16 AET37811.1 - 2e-31 109.2 36.5 2e-31 109.2 36.5 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AET37811.1 - 0.00029 19.8 42.6 0.0012 17.8 13.9 3.6 1 1 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 AET37811.1 - 0.09 11.6 21.7 6.9 5.4 20.8 2.6 1 1 0 1 1 1 0 MFS_1 like family Redoxin PF08534.10 AET37812.1 - 2.3e-27 95.5 0.0 2.7e-27 95.3 0.0 1.0 1 0 0 1 1 1 1 Redoxin DUF285 PF03382.14 AET37813.1 - 0.012 15.3 1.2 0.035 13.8 0.8 1.9 2 0 0 2 2 2 0 Mycoplasma protein of unknown function, DUF285 TPR_2 PF07719.17 AET37813.1 - 0.021 14.9 0.0 0.051 13.7 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat PCI PF01399.27 AET37813.1 - 0.029 14.9 5.8 0.41 11.2 0.1 3.5 2 2 1 3 3 3 0 PCI domain DUF4077 PF13295.6 AET37813.1 - 0.03 14.3 0.2 0.1 12.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4077) YvbH_ext PF11724.8 AET37813.1 - 0.031 14.6 0.0 0.11 12.8 0.0 1.9 1 0 0 1 1 1 0 YvbH-like oligomerisation region TPR_7 PF13176.6 AET37813.1 - 0.082 13.0 0.0 0.33 11.1 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat GCR1_C PF12550.8 AET37815.1 - 1.1e-22 80.1 0.2 2.2e-22 79.2 0.2 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes TFIIA PF03153.13 AET37815.1 - 0.00047 20.3 32.2 0.012 15.6 12.8 2.1 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 AET37815.1 - 2.9 7.7 14.6 2.7 7.7 3.8 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 PepSY_TM PF03929.16 AET37815.1 - 3.7 7.2 6.6 2.5 7.7 0.8 2.2 2 0 0 2 2 2 0 PepSY-associated TM region Suf PF05843.14 AET37815.1 - 9.4 6.1 18.7 9 6.2 6.2 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) TFIIA PF03153.13 AET37816.1 - 0.01 15.9 11.2 0.011 15.8 11.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4404 PF14357.6 AET37816.1 - 0.049 14.3 3.6 0.049 14.3 3.6 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) Paralemmin PF03285.15 AET37816.1 - 0.38 10.3 8.2 0.8 9.2 8.2 1.5 1 0 0 1 1 1 0 Paralemmin TDA11 PF17084.5 AET37817.1 - 6.6e-38 130.8 0.5 1.4e-27 96.8 0.0 3.1 1 1 2 3 3 3 3 Topoisomerase I damage affected protein 11 Kelch_5 PF13854.6 AET37818.1 - 3.8e-30 103.3 6.8 9.1e-06 25.5 0.1 6.7 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 AET37818.1 - 4.3e-27 93.8 1.3 8.3e-05 22.8 0.0 5.9 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.6 AET37818.1 - 2.1e-26 91.6 6.8 8.5e-06 25.7 0.2 6.6 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 AET37818.1 - 8.1e-22 76.7 7.7 9.3e-06 25.8 0.1 6.6 5 1 1 6 6 6 5 Kelch motif Kelch_1 PF01344.25 AET37818.1 - 1.8e-16 59.4 0.2 9.7e-07 28.3 0.0 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 AET37818.1 - 6.1e-10 38.7 3.5 0.32 11.1 0.0 6.6 7 0 0 7 7 7 3 Kelch motif DUF948 PF06103.11 AET37818.1 - 5.6 7.3 9.8 9.1 6.6 0.4 3.6 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) REC104 PF17378.2 AET37819.1 - 9.3e-06 25.6 0.4 5.5e-05 23.1 0.0 2.1 2 1 0 2 2 2 1 Meiotic recombination protein REC104 ApoO PF09769.9 AET37822.1 - 4.2e-32 110.8 0.0 1.9e-31 108.7 0.0 1.9 2 0 0 2 2 2 1 Apolipoprotein O RTT107_BRCT_6 PF16771.5 AET37823.1 - 1.4e-40 138.0 0.6 5e-40 136.2 0.1 2.3 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain RTT107_BRCT_5 PF16770.5 AET37823.1 - 1.7e-25 88.8 0.1 1.3e-23 82.8 0.0 3.1 3 0 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain PTCB-BRCT PF12738.7 AET37823.1 - 1.5e-21 76.1 2.6 1.2e-14 54.0 0.2 4.2 4 0 0 4 4 4 2 twin BRCT domain BRCT PF00533.26 AET37823.1 - 1.7e-21 76.4 9.7 9.3e-06 25.9 0.0 6.3 6 0 0 6 6 6 5 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 AET37823.1 - 1.5e-11 44.5 3.0 0.017 15.5 0.0 5.1 5 0 0 5 5 5 4 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 AET37823.1 - 0.00013 22.1 0.2 0.23 11.8 0.0 3.6 3 0 0 3 3 3 1 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 AET37823.1 - 0.00017 21.6 0.1 0.48 10.5 0.0 4.7 5 0 0 5 5 5 1 BRCA1 C Terminus (BRCT) domain Siah-Interact_N PF09032.11 AET37823.1 - 1.2 9.5 6.2 0.13 12.6 0.9 2.1 2 0 0 2 2 2 0 Siah interacting protein, N terminal Cir_N PF10197.9 AET37824.1 - 0.0044 17.2 1.1 0.0044 17.2 1.1 2.3 2 0 0 2 2 2 1 N-terminal domain of CBF1 interacting co-repressor CIR CRM1_C PF08767.11 AET37825.1 - 3.2e-133 443.9 3.0 3.2e-133 443.9 3.0 3.1 3 0 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 AET37825.1 - 2.2e-37 128.4 5.9 2.2e-37 128.4 5.9 4.0 4 0 0 4 4 4 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 AET37825.1 - 1.2e-31 108.1 2.4 3.9e-31 106.5 2.4 2.0 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 AET37825.1 - 7.9e-30 102.7 0.4 6.7e-29 99.8 0.4 2.8 1 0 0 1 1 1 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 AET37825.1 - 1.7e-16 59.4 0.6 1.7e-16 59.4 0.6 2.2 2 0 0 2 2 2 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 AET37825.1 - 2.8e-15 56.0 0.4 1.4e-13 50.5 0.0 3.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain DUF3385 PF11865.8 AET37825.1 - 0.041 13.8 3.2 0.14 12.1 0.0 3.5 3 1 1 4 4 4 0 Domain of unknown function (DUF3385) V-ATPase_H_C PF11698.8 AET37825.1 - 0.096 12.8 4.3 1.2 9.3 0.2 3.8 3 0 0 3 3 3 0 V-ATPase subunit H PLN_propep PF16485.5 AET37825.1 - 0.13 12.0 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 Protealysin propeptide DUF507 PF04368.13 AET37825.1 - 1.3 8.9 8.2 3.4 7.6 0.2 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF507) Ribosomal_L3 PF00297.22 AET37826.1 - 3.6e-16 59.1 1.2 1.3e-13 50.7 0.2 2.1 1 1 1 2 2 2 2 Ribosomal protein L3 Ribosomal_L6 PF00347.23 AET37827.1 - 7.6e-20 71.4 0.4 2.4e-09 37.7 0.2 2.3 2 0 0 2 2 2 2 Ribosomal protein L6 Ribosomal_S4 PF00163.19 AET37828.1 - 1.3e-11 45.2 2.3 2e-11 44.6 1.9 1.5 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.25 AET37828.1 - 1.4e-11 43.9 0.0 3.4e-11 42.7 0.0 1.7 2 0 0 2 2 2 1 S4 domain Herpes_LAMP2 PF06126.11 AET37828.1 - 0.0047 15.6 0.0 0.0055 15.4 0.0 1.1 1 0 0 1 1 1 1 Herpesvirus Latent membrane protein 2 RRM_1 PF00076.22 AET37829.1 - 0.003 17.3 0.1 0.01 15.7 0.0 2.0 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 AET37831.1 - 5.1e-10 39.8 6.7 0.11 13.4 0.0 6.5 8 0 0 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET37831.1 - 0.0003 21.0 0.0 10 6.5 0.0 4.1 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AET37831.1 - 0.027 13.8 0.0 5.7 6.2 0.0 2.4 2 0 0 2 2 2 0 WD40-like domain Pex24p PF06398.11 AET37832.1 - 3.4e-77 259.9 0.8 4.4e-77 259.5 0.8 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Reticulon PF02453.17 AET37832.1 - 0.013 15.4 0.2 2.1 8.3 0.1 2.3 2 0 0 2 2 2 0 Reticulon NAAA-beta PF15508.6 AET37832.1 - 0.052 13.8 0.0 0.15 12.4 0.0 1.8 1 0 0 1 1 1 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase RTC4 PF14474.6 AET37832.1 - 0.14 12.3 0.1 0.54 10.4 0.1 1.9 2 0 0 2 2 2 0 RTC4-like domain Lectin_C PF00059.21 AET37833.1 - 0.00072 20.3 0.5 0.43 11.3 0.9 2.5 2 0 0 2 2 2 2 Lectin C-type domain DIE2_ALG10 PF04922.12 AET37834.1 - 2.3e-107 359.7 32.5 3e-107 359.3 32.5 1.1 1 0 0 1 1 1 1 DIE2/ALG10 family DUF4519 PF15012.6 AET37834.1 - 0.17 12.0 0.1 0.47 10.7 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) SMI1_KNR4 PF09346.10 AET37835.1 - 2e-35 122.1 0.1 1.3e-34 119.4 0.0 2.5 3 1 0 3 3 3 1 SMI1 / KNR4 family (SUKH-1) Spo12 PF05032.12 AET37836.1 - 4.6e-18 64.8 3.8 4.6e-18 64.8 3.8 2.1 2 0 0 2 2 2 1 Spo12 family Ank_2 PF12796.7 AET37837.1 - 6.1e-35 119.7 0.1 6.8e-11 42.6 0.0 4.0 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 AET37837.1 - 2.9e-31 107.4 3.6 8.8e-09 35.7 0.1 5.1 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 AET37837.1 - 1e-26 90.0 0.4 0.017 15.6 0.0 7.0 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 AET37837.1 - 2.8e-25 88.0 1.6 1.3e-06 28.6 0.0 5.8 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 AET37837.1 - 6.8e-20 70.6 0.7 1.3e-05 25.4 0.0 6.7 7 0 0 7 7 7 4 Ankyrin repeat Ion_trans PF00520.31 AET37838.1 - 8.4e-105 349.4 110.8 3.9e-38 131.1 21.1 5.0 4 1 0 4 4 4 4 Ion transport protein EF-hand_1 PF00036.32 AET37838.1 - 0.0027 17.1 0.2 0.014 14.9 0.2 2.3 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 AET37838.1 - 0.038 13.9 0.2 0.22 11.5 0.2 2.4 1 0 0 1 1 1 0 EF-hand domain Gpi1 PF05024.15 AET37839.1 - 4e-57 193.3 16.8 4e-57 193.3 16.8 2.3 2 0 0 2 2 2 1 N-acetylglucosaminyl transferase component (Gpi1) MRP-S33 PF08293.11 AET37840.1 - 3.4e-33 113.7 0.1 4.1e-33 113.5 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Ribosomal_S2 PF00318.20 AET37841.1 - 7.2e-25 87.5 0.1 4.9e-13 48.8 0.0 2.2 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 AET37841.1 - 7.2e-05 24.1 8.8 0.00015 23.1 8.8 1.5 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Glucan_synthase PF02364.15 AET37842.1 - 0 1104.6 0.4 0 1104.6 0.4 1.6 2 0 0 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 AET37842.1 - 1.5e-24 86.8 5.8 2e-23 83.2 5.8 2.5 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 TPR_1 PF00515.28 AET37843.1 - 5.5e-12 45.0 0.4 4.4e-07 29.5 0.2 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 AET37843.1 - 5.3e-10 38.6 0.1 4.3e-05 23.3 0.1 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 AET37843.1 - 1.4e-09 37.5 0.1 3.4e-09 36.2 0.1 1.7 1 1 1 2 2 2 1 TPR repeat ANAPC3 PF12895.7 AET37843.1 - 6.5e-08 32.7 0.2 9e-08 32.2 0.2 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 AET37843.1 - 1e-06 28.4 0.0 0.0016 18.3 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 AET37843.1 - 7.7e-06 25.7 0.3 0.00017 21.6 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 AET37843.1 - 2.5e-05 24.5 0.0 0.026 14.8 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 AET37843.1 - 4.3e-05 24.0 0.0 6.6e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 AET37843.1 - 0.00027 21.1 0.2 0.05 14.0 0.2 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 AET37843.1 - 0.0095 15.8 0.0 0.94 9.4 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat SRP_TPR_like PF17004.5 AET37843.1 - 0.018 15.1 0.1 0.1 12.6 0.0 2.0 1 1 1 2 2 2 0 Putative TPR-like repeat TPR_16 PF13432.6 AET37843.1 - 0.023 15.4 0.0 0.82 10.4 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 AET37843.1 - 0.034 14.9 0.0 2 9.5 0.0 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 AET37843.1 - 0.047 13.7 0.2 0.12 12.4 0.2 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat UPF0029 PF01205.19 AET37844.1 - 1.3e-31 109.0 0.0 2e-31 108.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 AET37844.1 - 9.1e-09 35.6 0.1 2e-08 34.5 0.1 1.6 1 1 0 1 1 1 1 RWD domain Sortase PF04203.13 AET37844.1 - 0.011 15.5 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 0 Sortase domain MPP6 PF10175.9 AET37845.1 - 5.6e-14 52.8 5.3 7.1e-14 52.4 5.3 1.2 1 0 0 1 1 1 1 M-phase phosphoprotein 6 WD40 PF00400.32 AET37846.1 - 2.1e-46 154.9 14.8 2.7e-09 37.5 0.2 12.6 13 0 0 13 13 13 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET37846.1 - 2.9e-30 104.4 0.1 0.0004 20.6 0.0 10.2 4 3 7 12 12 12 7 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 AET37846.1 - 2e-22 79.5 0.0 3.3e-22 78.8 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Ge1_WD40 PF16529.5 AET37846.1 - 6.5e-09 35.2 3.2 0.012 14.5 0.0 6.2 4 3 3 7 7 7 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 AET37846.1 - 2.1e-08 34.3 6.8 0.00048 20.1 0.2 5.7 5 2 3 8 8 8 3 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 AET37846.1 - 2e-06 27.3 0.4 2 7.7 0.0 4.5 3 1 1 4 4 4 3 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 AET37846.1 - 9.2e-06 24.6 2.2 0.77 8.3 0.0 4.5 3 1 1 5 5 5 2 Nucleoporin Nup120/160 WD40_like PF17005.5 AET37846.1 - 3e-05 23.5 6.3 2.1 7.6 0.0 5.3 3 1 3 6 6 6 2 WD40-like domain SGL PF08450.12 AET37846.1 - 0.0001 22.0 0.2 1.4 8.5 0.0 3.8 2 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region WD40_3 PF15911.5 AET37846.1 - 0.0002 21.3 0.0 0.00082 19.3 0.0 2.0 2 0 0 2 2 2 1 WD domain, G-beta repeat Utp8 PF10395.9 AET37846.1 - 0.036 12.6 0.3 4.7 5.6 0.0 3.3 3 1 1 4 4 4 0 Utp8 family PD40 PF07676.12 AET37846.1 - 0.043 13.8 3.4 7.7 6.6 0.1 3.9 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 AET37846.1 - 0.12 12.0 2.6 6.3 6.6 0.2 4.0 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Atx10homo_assoc PF09759.9 AET37847.1 - 1.8e-38 130.5 1.2 5.8e-38 128.9 1.2 1.9 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain Thr_synth_N PF14821.6 AET37848.1 - 1.1e-26 92.9 0.0 3.6e-26 91.2 0.0 2.0 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 AET37848.1 - 7.5e-13 48.5 0.0 1.2e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SWIB PF02201.18 AET37849.1 - 0.00012 21.9 2.2 0.00049 19.9 0.4 2.6 2 1 0 2 2 2 1 SWIB/MDM2 domain ACCA PF03255.14 AET37849.1 - 0.12 12.3 1.0 2.1 8.2 0.0 2.6 3 0 0 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Ribosomal_L9_N PF01281.19 AET37850.1 - 3.9e-06 26.3 0.1 6.9e-06 25.5 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain DUF1682 PF07946.14 AET37851.1 - 1.9e-74 250.8 9.5 2.3e-74 250.5 9.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF3140 PF11338.8 AET37851.1 - 0.018 15.4 3.7 0.029 14.8 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3140) Ank_5 PF13857.6 AET37852.1 - 5e-15 55.4 0.2 1.8e-10 40.9 0.2 3.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 AET37852.1 - 1.2e-11 45.0 0.2 5.1e-10 39.8 0.2 2.2 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 AET37852.1 - 6.4e-10 39.4 0.3 2.9e-06 27.7 0.2 3.4 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 AET37852.1 - 2.2e-07 31.0 0.4 0.00078 19.8 0.3 3.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 AET37852.1 - 6.8e-06 26.0 0.3 0.0055 17.1 0.1 4.2 4 1 0 4 4 4 1 Ankyrin repeat MRG PF05712.13 AET37852.1 - 0.064 12.6 0.4 2.1 7.6 0.3 2.3 2 0 0 2 2 2 0 MRG Peptidase_M76 PF09768.9 AET37853.1 - 1.5e-70 236.4 2.1 1.8e-70 236.2 2.1 1.1 1 0 0 1 1 1 1 Peptidase M76 family MBOAT PF03062.19 AET37854.1 - 1.8e-67 228.2 38.1 2.2e-67 227.9 38.1 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 AET37854.1 - 0.0032 17.7 4.2 0.0032 17.7 4.2 2.0 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family SUIM_assoc PF16619.5 AET37854.1 - 0.016 15.2 2.2 0.039 14.0 2.2 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Methyltransf_11 PF08241.12 AET37855.1 - 3.6e-13 50.0 0.0 8.7e-13 48.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain WBS_methylT PF12589.8 AET37855.1 - 9.4e-13 48.7 8.2 1.9e-12 47.8 8.2 1.5 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_25 PF13649.6 AET37855.1 - 2.4e-11 44.2 0.0 8.9e-11 42.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AET37855.1 - 8.7e-07 28.9 0.0 1.8e-06 27.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AET37855.1 - 1.1e-06 29.3 0.0 3.7e-06 27.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AET37855.1 - 2.1e-06 27.6 0.0 3e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 AET37855.1 - 6.2e-05 22.8 0.0 0.00086 19.1 0.0 2.1 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 AET37855.1 - 0.00014 21.2 0.0 0.00038 19.8 0.0 1.7 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 AET37855.1 - 0.00048 19.6 0.4 0.0056 16.1 0.1 2.2 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 AET37855.1 - 0.0027 17.3 0.0 0.0078 15.8 0.0 1.7 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW AdoMet_MTase PF07757.13 AET37855.1 - 0.0066 16.8 0.0 0.015 15.6 0.0 1.6 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 AET37855.1 - 0.0072 16.3 0.4 0.4 10.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain TPMT PF05724.11 AET37855.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Ribosomal_L19 PF01245.20 AET37856.1 - 1.1e-11 44.6 0.3 1.8e-11 44.0 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L19 HIG_1_N PF04588.13 AET37857.1 - 4.5e-05 23.6 0.7 9.3e-05 22.6 0.7 1.5 1 0 0 1 1 1 1 Hypoxia induced protein conserved region DUF454 PF04304.13 AET37857.1 - 1.7 8.7 5.2 1.3 9.1 1.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF454) Peptidase_S8 PF00082.22 AET37858.1 - 1.4e-30 106.6 4.0 1.4e-30 106.6 4.0 1.9 1 1 0 1 1 1 1 Subtilase family CDC45 PF02724.14 AET37858.1 - 2.4 6.4 7.6 3.4 5.9 7.6 1.2 1 0 0 1 1 1 0 CDC45-like protein Tim17 PF02466.19 AET37859.1 - 1.7e-26 92.7 3.4 2.2e-26 92.4 3.4 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family ACC_central PF08326.12 AET37860.1 - 1.4e-263 876.6 0.1 1.9e-263 876.1 0.1 1.2 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 AET37860.1 - 8.9e-184 611.7 0.0 1.2e-183 611.3 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 AET37860.1 - 9.1e-51 172.3 0.0 1.9e-50 171.3 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 AET37860.1 - 3.9e-29 101.4 0.0 8e-29 100.4 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 AET37860.1 - 2.8e-20 72.4 0.0 6.8e-20 71.2 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 AET37860.1 - 3.6e-15 55.6 0.0 9.8e-15 54.2 0.0 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_3 PF02655.14 AET37860.1 - 0.00011 22.3 0.0 0.00059 19.9 0.0 2.3 2 0 0 2 2 2 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 AET37860.1 - 0.0055 16.3 0.0 0.015 14.9 0.0 1.7 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus GxGYxYP_N PF16216.5 AET37860.1 - 0.02 15.0 0.0 0.053 13.7 0.0 1.6 1 0 0 1 1 1 0 GxGYxY sequence motif in domain of unknown function N-terminal ATPgrasp_Ter PF15632.6 AET37860.1 - 0.067 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon ABC_tran_CTD PF16326.5 AET37860.1 - 0.076 13.3 2.1 0.25 11.6 2.1 1.9 1 0 0 1 1 1 0 ABC transporter C-terminal domain Dus PF01207.17 AET37861.1 - 2.5e-53 181.2 0.0 1.6e-52 178.6 0.0 1.9 1 1 1 2 2 2 2 Dihydrouridine synthase (Dus) DUF1708 PF08101.11 AET37862.1 - 2.5e-83 280.6 4.7 2.5e-83 280.6 4.7 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1708) DUF4667 PF15700.5 AET37863.1 - 3.3e-15 56.9 0.0 3.6e-13 50.2 0.0 2.9 3 0 0 3 3 3 2 Domain of unknown function (DUF4667) SPX PF03105.19 AET37864.1 - 3.2e-34 119.5 11.6 1.5e-20 74.5 3.8 2.9 1 1 1 2 2 2 2 SPX domain Na_sulph_symp PF00939.19 AET37864.1 - 5.5e-29 101.5 41.1 7.5e-29 101.1 41.1 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 AET37864.1 - 4.3e-23 82.0 71.4 4.8e-22 78.5 40.8 2.3 1 1 1 2 2 2 2 Citrate transporter BLI1 PF17324.2 AET37864.1 - 0.054 14.2 1.7 0.92 10.2 0.6 2.3 2 0 0 2 2 2 0 BLOC-1 interactor 1 PRK PF00485.18 AET37865.1 - 4.1e-66 222.5 0.0 6e-66 221.9 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 AET37865.1 - 9.6e-34 116.6 0.1 2.3e-33 115.4 0.1 1.6 2 0 0 2 2 2 1 Uracil phosphoribosyltransferase AAA_18 PF13238.6 AET37865.1 - 2.2e-05 25.0 0.0 5.4e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 AET37865.1 - 0.003 17.4 0.0 0.0062 16.4 0.0 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 AET37865.1 - 0.0032 16.8 0.0 0.006 15.9 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_17 PF13207.6 AET37865.1 - 0.0035 17.8 0.1 5.2 7.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain CoaE PF01121.20 AET37865.1 - 0.033 13.8 0.1 8 6.1 0.0 2.6 3 0 0 3 3 3 0 Dephospho-CoA kinase AAA_33 PF13671.6 AET37865.1 - 0.076 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 AET37865.1 - 0.078 12.7 0.1 0.38 10.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain CbiA PF01656.23 AET37865.1 - 0.099 12.7 0.5 0.26 11.4 0.6 1.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain HA2 PF04408.23 AET37866.1 - 3.5e-16 59.4 0.0 1e-15 57.9 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 AET37866.1 - 4.7e-16 59.1 0.1 1.8e-15 57.3 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 AET37866.1 - 3.7e-12 46.4 0.0 7.9e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 AET37866.1 - 1.1e-06 28.5 0.1 2.3e-06 27.5 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AET37866.1 - 0.00027 21.2 0.1 0.00086 19.6 0.1 1.8 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 AET37866.1 - 0.00053 19.1 0.0 0.001 18.2 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 AET37866.1 - 0.00066 20.0 0.2 0.0015 18.9 0.2 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AET37866.1 - 0.0016 18.2 0.0 0.0033 17.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 AET37866.1 - 0.0067 16.4 0.1 0.014 15.3 0.1 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain ATPase PF06745.13 AET37866.1 - 0.016 14.5 0.0 0.33 10.3 0.0 2.7 2 0 0 2 2 2 0 KaiC SRP54 PF00448.22 AET37866.1 - 0.051 13.2 0.2 0.095 12.3 0.2 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ResIII PF04851.15 AET37866.1 - 0.058 13.4 0.2 2.2 8.3 0.3 2.9 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit PhoH PF02562.16 AET37866.1 - 0.067 12.6 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 AET37866.1 - 0.07 13.6 0.3 0.73 10.3 0.0 2.5 2 0 0 2 2 2 0 ABC transporter PFK PF00365.20 AET37867.1 - 1.2e-180 599.0 2.6 1.1e-100 336.6 1.9 2.3 2 0 0 2 2 2 2 Phosphofructokinase UVR PF02151.19 AET37867.1 - 0.76 9.6 2.1 0.78 9.6 0.2 2.0 2 0 0 2 2 2 0 UvrB/uvrC motif Inp1 PF12634.7 AET37868.1 - 1.5e-24 86.5 0.2 4e-24 85.2 0.1 1.8 2 0 0 2 2 2 1 Inheritance of peroxisomes protein 1 Porin_3 PF01459.22 AET37869.1 - 6.1e-88 294.8 0.2 7.1e-88 294.6 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic porin Med9 PF07544.13 AET37870.1 - 3.8e-21 75.0 0.2 5.3e-21 74.5 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Peptidase_M9_N PF08453.10 AET37870.1 - 0.094 12.4 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M9 N-terminal ERG2_Sigma1R PF04622.12 AET37871.1 - 9e-92 306.1 0.1 1.1e-91 305.8 0.1 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Whi5 PF08528.11 AET37872.1 - 1.2e-10 40.8 0.6 1.9e-10 40.1 0.6 1.4 1 0 0 1 1 1 1 Whi5 like LCAT PF02450.15 AET37873.1 - 5.4e-122 407.7 0.0 6.7e-122 407.4 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF726 PF05277.12 AET37873.1 - 0.041 12.8 0.0 0.076 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF726) Abhydrolase_6 PF12697.7 AET37873.1 - 0.13 12.9 0.0 0.23 12.1 0.0 1.7 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF900 PF05990.12 AET37873.1 - 0.15 11.5 0.1 1.6 8.2 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Autophagy_N PF03986.13 AET37874.1 - 7.9e-43 145.7 0.6 7.9e-43 145.7 0.6 1.7 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_C PF10381.9 AET37874.1 - 2.4e-15 55.7 1.0 4.3e-15 54.9 1.0 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Autophagy_act_C PF03987.15 AET37874.1 - 2.3e-14 53.7 0.3 5.3e-14 52.5 0.1 1.8 2 0 0 2 2 2 1 Autophagocytosis associated protein, active-site domain 5_nucleotid_C PF02872.18 AET37874.1 - 0.037 14.3 0.1 0.071 13.3 0.1 1.4 1 0 0 1 1 1 0 5'-nucleotidase, C-terminal domain XPA_C PF05181.12 AET37875.1 - 1.1e-20 73.3 0.1 2.5e-20 72.2 0.1 1.7 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 AET37875.1 - 0.01 15.9 0.3 0.03 14.4 0.3 1.8 1 0 0 1 1 1 0 XPA protein N-terminal VHS PF00790.19 AET37876.1 - 1.6e-38 131.7 0.1 3.9e-38 130.5 0.1 1.7 1 0 0 1 1 1 1 VHS domain FYVE PF01363.21 AET37876.1 - 1.7e-18 66.5 1.7 1.7e-18 66.5 1.7 2.2 2 1 0 2 2 2 1 FYVE zinc finger UIM PF02809.20 AET37876.1 - 5e-05 22.9 4.5 0.00056 19.7 0.7 4.0 4 0 0 4 4 4 2 Ubiquitin interaction motif FYVE_2 PF02318.16 AET37876.1 - 0.001 19.2 1.9 0.001 19.2 1.9 2.9 3 0 0 3 3 3 1 FYVE-type zinc finger GAT PF03127.14 AET37876.1 - 0.0025 18.1 1.6 0.01 16.2 1.6 2.1 1 0 0 1 1 1 1 GAT domain OAD_gamma PF04277.13 AET37876.1 - 0.35 11.5 2.4 9 7.0 2.4 2.5 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Rot1 PF10681.9 AET37877.1 - 2.2e-93 311.6 0.0 2.5e-93 311.4 0.0 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal Cyclin_N PF00134.23 AET37878.1 - 2.4e-39 134.0 0.0 4.9e-39 133.0 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain COBRA PF04833.15 AET37878.1 - 0.11 12.3 1.8 0.11 12.3 0.4 1.7 2 0 0 2 2 2 0 COBRA-like protein 40S_S4_C PF16121.5 AET37879.1 - 0.037 13.7 0.1 0.083 12.5 0.1 1.5 1 0 0 1 1 1 0 40S ribosomal protein S4 C-terminus I-EGF_1 PF18372.1 AET37879.1 - 1.6 8.9 3.3 3.3 7.9 3.3 1.6 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 BBP1_C PF15272.6 AET37880.1 - 1.6e-29 103.1 29.7 1.1e-28 100.4 26.9 2.6 2 1 0 2 2 2 1 Spindle pole body component BBP1, C-terminal BBP1_N PF15271.6 AET37880.1 - 6.5e-26 91.9 0.3 6.5e-26 91.9 0.3 2.8 2 1 0 2 2 2 1 Spindle pole body component BBP1, Mps2-binding protein Microtub_bd PF16796.5 AET37881.1 - 3.6e-23 82.1 1.3 3.6e-23 82.1 1.3 3.2 2 1 1 3 3 3 1 Microtubule binding Polysacc_deac_2 PF04748.13 AET37881.1 - 0.022 14.0 3.2 0.14 11.3 1.2 2.3 1 1 1 2 2 2 0 Divergent polysaccharide deacetylase GAS PF13851.6 AET37881.1 - 9.6 5.5 56.7 1.2 8.5 20.6 3.2 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Fer2 PF00111.27 AET37882.1 - 7.9e-13 48.2 2.6 1.1e-12 47.8 2.6 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain PH_14 PF17787.1 AET37882.1 - 0.088 12.7 0.0 8 6.3 0.0 2.1 1 1 1 2 2 2 0 PH domain V-SNARE_C PF12352.8 AET37883.1 - 9.6e-16 57.8 3.2 9.6e-16 57.8 3.2 3.2 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.15 AET37883.1 - 3.1e-15 56.3 1.4 3.1e-15 56.3 1.4 2.1 2 1 1 3 3 3 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.13 AET37883.1 - 6.1e-05 22.9 7.0 0.00081 19.3 0.4 3.1 2 1 1 3 3 3 1 Sec20 DUF1744 PF08490.12 AET37883.1 - 0.0029 16.3 0.9 0.55 8.7 0.2 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF1744) Phage_Mu_Gam PF07352.12 AET37883.1 - 0.028 14.3 1.2 0.038 13.9 0.2 1.7 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein MCPsignal PF00015.21 AET37883.1 - 0.05 13.4 1.0 8.7 6.1 0.1 2.2 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain RasGAP_C PF03836.15 AET37883.1 - 0.065 13.4 5.5 0.069 13.3 0.6 2.5 2 1 0 2 2 2 0 RasGAP C-terminus YqjK PF13997.6 AET37883.1 - 0.071 13.4 0.7 0.34 11.2 0.0 2.5 2 0 0 2 2 2 0 YqjK-like protein Fzo_mitofusin PF04799.13 AET37883.1 - 0.097 12.2 3.4 0.092 12.3 0.8 2.0 2 0 0 2 2 2 0 fzo-like conserved region DUF5089 PF17002.5 AET37883.1 - 0.23 11.3 3.4 0.64 9.9 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5089) Nsp1_C PF05064.13 AET37883.1 - 0.31 10.9 7.1 0.28 11.0 0.2 3.1 2 1 2 4 4 4 0 Nsp1-like C-terminal region TPR_MLP1_2 PF07926.12 AET37883.1 - 0.97 9.5 6.6 1.2 9.3 0.9 2.3 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.10 AET37883.1 - 1.6 8.9 9.7 9.3 6.4 3.6 3.0 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF745 PF05335.13 AET37883.1 - 2.5 7.8 5.7 1.1 8.9 0.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) APG6_N PF17675.1 AET37883.1 - 3.5 8.1 7.3 2.2 8.8 3.7 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF948 PF06103.11 AET37883.1 - 6.6 7.1 7.0 12 6.2 3.8 3.0 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Glyco_hydro_63 PF03200.16 AET37884.1 - 3.9e-06 25.9 11.0 9.7e-05 21.3 0.1 4.5 5 1 0 5 5 5 2 Glycosyl hydrolase family 63 C-terminal domain DUF4357 PF14267.6 AET37885.1 - 0.6 10.1 4.0 10 6.2 0.1 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4357) MTCP1 PF08991.10 AET37886.1 - 2.6e-20 72.4 4.7 2.6e-20 72.4 4.7 2.0 2 0 0 2 2 2 1 Mature-T-Cell Proliferation I type Ribosomal_L36e PF01158.18 AET37887.1 - 1.3e-37 128.0 3.2 1.4e-37 127.8 3.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e DUF2207 PF09972.9 AET37887.1 - 0.1 11.3 0.1 0.11 11.3 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TetR_C_9 PF14514.6 AET37887.1 - 0.15 12.2 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Ribosomal_L28 PF00830.19 AET37888.1 - 1.3e-20 73.4 1.0 3.2e-20 72.1 1.0 1.7 1 0 0 1 1 1 1 Ribosomal L28 family RabGAP-TBC PF00566.18 AET37889.1 - 1.7e-49 168.4 0.3 1.7e-49 168.4 0.3 2.7 3 0 0 3 3 3 1 Rab-GTPase-TBC domain DivIC PF04977.15 AET37889.1 - 0.22 11.3 23.9 2.5 7.9 2.6 4.6 2 1 1 3 3 3 0 Septum formation initiator CENP-F_leu_zip PF10473.9 AET37889.1 - 1.5 8.9 34.2 0.28 11.2 12.1 4.0 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1192 PF06698.11 AET37889.1 - 5.7 7.1 8.7 0.22 11.6 0.6 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) RQC PF09382.10 AET37890.1 - 1.2e-28 99.2 0.1 2.5e-28 98.1 0.1 1.6 1 0 0 1 1 1 1 RQC domain Helicase_C PF00271.31 AET37890.1 - 6.2e-23 81.3 0.6 3e-17 63.0 0.0 3.8 4 0 0 4 4 4 2 Helicase conserved C-terminal domain DEAD PF00270.29 AET37890.1 - 9.9e-23 80.8 0.0 3e-22 79.2 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 AET37890.1 - 3.4e-17 62.9 9.3 1.2e-16 61.2 9.3 2.1 1 0 0 1 1 1 1 RecQ zinc-binding Helicase_Sgs1 PF11408.8 AET37890.1 - 2.4e-06 27.5 0.0 8e-06 25.8 0.0 1.9 1 0 0 1 1 1 1 Sgs1 RecQ helicase ResIII PF04851.15 AET37890.1 - 4.1e-06 26.9 0.0 1.7e-05 24.9 0.0 2.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Rhodanese PF00581.20 AET37890.1 - 0.039 14.5 0.2 0.29 11.7 0.0 2.5 2 0 0 2 2 2 0 Rhodanese-like domain WD40 PF00400.32 AET37891.1 - 5e-13 49.3 12.3 0.00051 20.8 0.1 6.2 7 0 0 7 7 7 4 WD domain, G-beta repeat Ribosomal_S17 PF00366.20 AET37892.1 - 4e-23 81.3 0.5 7.7e-23 80.4 0.5 1.5 1 0 0 1 1 1 1 Ribosomal protein S17 DHQS PF01959.16 AET37892.1 - 0.078 11.9 3.8 0.27 10.1 3.8 1.8 1 1 0 1 1 1 0 3-dehydroquinate synthase II Rhomboid PF01694.22 AET37893.1 - 2.3e-20 73.1 7.2 3.7e-20 72.4 7.2 1.2 1 0 0 1 1 1 1 Rhomboid family TIM21 PF08294.11 AET37893.1 - 0.04 13.8 0.4 0.076 12.9 0.4 1.4 1 0 0 1 1 1 0 TIM21 UAA PF08449.11 AET37894.1 - 5.5e-40 137.5 13.8 6.4e-40 137.2 13.8 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 AET37894.1 - 1.1e-08 35.4 8.0 1.1e-08 35.4 8.0 3.1 2 1 1 3 3 3 1 EamA-like transporter family TPT PF03151.16 AET37894.1 - 0.00012 21.5 8.6 0.00049 19.5 1.6 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family SRP68 PF16969.5 AET37895.1 - 4.3e-58 197.7 16.8 5.3e-58 197.4 16.8 1.1 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 Bac_rhamnosid6H PF17389.2 AET37895.1 - 0.05 12.8 0.0 0.12 11.6 0.0 1.6 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain TRAF6_Z2 PF18048.1 AET37896.1 - 0.0036 17.4 0.1 0.0079 16.3 0.1 1.5 1 0 0 1 1 1 1 TNF receptor-associated factor 6 zinc finger 2 RINGv PF12906.7 AET37896.1 - 0.0046 17.1 8.3 0.013 15.7 8.3 1.8 1 0 0 1 1 1 1 RING-variant domain FANCL_C PF11793.8 AET37896.1 - 0.075 13.2 9.6 0.048 13.9 5.5 2.4 2 0 0 2 2 2 0 FANCL C-terminal domain zf-RING_2 PF13639.6 AET37896.1 - 2.8 8.3 9.6 1.3 9.4 5.1 2.6 2 0 0 2 2 2 0 Ring finger domain RasGAP_C PF03836.15 AET37898.1 - 8.1e-29 100.5 1.4 8.1e-29 100.5 1.4 2.6 2 0 0 2 2 2 1 RasGAP C-terminus RasGAP PF00616.19 AET37898.1 - 4.3e-13 49.5 1.7 4.3e-13 49.5 1.7 2.2 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase CH PF00307.31 AET37898.1 - 1.3e-12 47.8 0.1 7.9e-12 45.3 0.0 2.5 2 0 0 2 2 2 1 Calponin homology (CH) domain IQ PF00612.27 AET37898.1 - 4.4e-05 22.9 16.7 6.4 6.9 0.0 7.2 7 0 0 7 7 7 3 IQ calmodulin-binding motif DUF2280 PF10045.9 AET37898.1 - 0.05 13.9 0.0 0.72 10.2 0.0 2.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2280) PXA PF02194.15 AET37898.1 - 0.058 13.4 0.9 15 5.5 0.3 3.0 2 0 0 2 2 2 0 PXA domain TBCC PF07986.12 AET37899.1 - 0.00022 20.9 5.8 0.00075 19.2 5.8 1.9 1 1 0 1 1 1 1 Tubulin binding cofactor C HSP90 PF00183.18 AET37900.1 - 2e-218 726.5 30.9 2.9e-218 726.0 30.9 1.2 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 AET37900.1 - 6.2e-14 52.5 0.1 1.3e-13 51.5 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 AET37900.1 - 4.5e-09 36.2 0.0 1.3e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cofac_haem_bdg PF04187.13 AET37900.1 - 0.049 13.6 0.1 0.15 12.0 0.1 1.9 1 0 0 1 1 1 0 Haem-binding uptake, Tiki superfamily, ChaN Tau95 PF09734.9 AET37900.1 - 1.6 9.5 4.2 2.4 8.9 0.9 2.8 3 0 0 3 3 3 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain RTP1_C1 PF10363.9 AET37901.1 - 2e-32 111.7 4.2 1.8e-31 108.6 0.0 4.0 5 0 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 AET37901.1 - 0.15 12.5 0.1 0.84 10.1 0.0 2.4 2 0 0 2 2 2 0 HEAT repeats Ank_2 PF12796.7 AET37902.1 - 1.2e-16 61.1 0.1 2.7e-16 59.9 0.1 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 AET37902.1 - 1.8e-16 59.9 0.8 2.7e-08 33.9 0.2 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 AET37902.1 - 4.6e-14 52.6 0.1 1.1e-13 51.4 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 AET37902.1 - 1.1e-13 50.9 0.1 2.2e-06 27.8 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 AET37902.1 - 7.9e-13 47.4 0.1 2.4e-05 24.4 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat eIF-5_eIF-2B PF01873.17 AET37903.1 - 7.8e-39 132.2 0.2 1.7e-38 131.1 0.2 1.5 1 0 0 1 1 1 1 Domain found in IF2B/IF5 IF2_N PF04760.15 AET37903.1 - 0.0063 16.3 1.6 0.053 13.3 0.0 3.1 3 1 1 4 4 4 1 Translation initiation factor IF-2, N-terminal region TF_Zn_Ribbon PF08271.12 AET37903.1 - 0.028 13.9 0.2 0.069 12.7 0.2 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding Prok-RING_2 PF14445.6 AET37903.1 - 0.1 12.8 0.1 2.3 8.4 0.0 2.5 2 1 0 2 2 2 0 Prokaryotic RING finger family 2 DUF2752 PF10825.8 AET37903.1 - 0.2 11.7 0.0 0.33 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2752) Arc_trans_TRASH PF08394.10 AET37903.1 - 3.1 8.2 6.2 31 5.0 2.4 2.8 1 1 1 2 2 2 0 Archaeal TRASH domain Pkinase PF00069.25 AET37905.1 - 6.4e-23 81.5 0.0 3.3e-12 46.3 0.0 2.4 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AET37905.1 - 2.4e-10 40.1 0.0 9.7e-05 21.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase TIP49 PF06068.13 AET37906.1 - 3.5e-156 519.8 1.4 4.3e-156 519.5 1.4 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 AET37906.1 - 2.9e-25 88.2 1.5 7.7e-25 86.8 1.3 1.9 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 AET37906.1 - 1.3e-08 35.4 0.5 6.9e-05 23.3 0.1 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 AET37906.1 - 1.9e-07 30.9 0.7 0.002 17.9 0.0 2.6 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain DnaB_C PF03796.15 AET37906.1 - 1e-05 25.0 0.1 2.1e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 AET37906.1 - 0.00034 21.0 0.2 0.0019 18.6 0.2 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AET37906.1 - 0.00061 20.1 0.0 0.3 11.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 AET37906.1 - 0.0047 17.2 0.1 0.013 15.7 0.1 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AET37906.1 - 0.0055 17.0 0.7 0.034 14.5 0.1 2.4 2 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 AET37906.1 - 0.0061 16.0 0.9 0.15 11.4 0.3 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 AET37906.1 - 0.0094 16.0 0.2 2 8.4 0.0 3.1 2 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 AET37906.1 - 0.015 14.8 0.1 0.032 13.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 AET37906.1 - 0.051 13.3 0.0 9 6.0 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_18 PF13238.6 AET37906.1 - 0.059 13.9 0.2 0.25 11.9 0.0 2.1 3 0 0 3 3 2 0 AAA domain ATP-synt_C PF00137.21 AET37907.1 - 2.3e-31 107.9 31.0 5.7e-19 68.2 9.8 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Mis14 PF08641.12 AET37908.1 - 1.1e-29 103.4 3.6 1.1e-29 103.4 3.6 1.8 2 0 0 2 2 2 1 Kinetochore protein Mis14 like Erp_C PF06780.11 AET37908.1 - 0.0076 16.3 4.2 0.3 11.1 1.3 2.2 1 1 1 2 2 2 2 Erp protein C-terminus PXB PF12828.7 AET37908.1 - 0.072 13.1 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 PX-associated HWE_HK PF07536.14 AET37908.1 - 0.16 12.7 1.0 23 5.8 0.1 3.2 2 1 1 3 3 3 0 HWE histidine kinase Syntaxin PF00804.25 AET37909.1 - 3.5e-20 72.5 17.1 3.5e-20 72.5 17.1 2.4 1 1 1 2 2 2 1 Syntaxin SNARE PF05739.19 AET37909.1 - 4.2e-14 52.3 3.3 4.2e-14 52.3 3.3 2.0 2 0 0 2 2 1 1 SNARE domain Synaptobrevin PF00957.21 AET37909.1 - 0.00034 20.4 3.2 0.00034 20.4 3.2 2.1 2 0 0 2 2 2 1 Synaptobrevin Thr_dehydrat_C PF00585.18 AET37909.1 - 0.0044 16.8 3.0 0.03 14.1 0.0 3.1 3 0 0 3 3 3 1 C-terminal regulatory domain of Threonine dehydratase SKA1 PF07160.12 AET37909.1 - 0.0057 16.5 4.0 0.0057 16.5 4.0 2.1 2 0 0 2 2 2 1 Spindle and kinetochore-associated protein 1 DUF2277 PF10041.9 AET37909.1 - 0.033 14.5 1.2 1.4 9.3 0.9 2.9 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2277) DUF948 PF06103.11 AET37909.1 - 0.036 14.3 3.4 0.036 14.3 3.4 3.8 3 1 1 4 4 3 0 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.12 AET37909.1 - 0.062 13.3 9.5 0.37 10.8 2.1 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Herpes_US9 PF06072.11 AET37909.1 - 0.065 13.1 0.3 0.12 12.2 0.3 1.4 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 DUF2207 PF09972.9 AET37909.1 - 0.15 10.8 1.9 0.13 11.0 0.2 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) LZ_Tnp_IS66 PF13007.7 AET37909.1 - 0.25 12.1 7.9 1.2e+02 3.5 7.9 2.8 1 1 0 1 1 1 0 Transposase C of IS166 homeodomain PBP1_TM PF14812.6 AET37909.1 - 0.3 11.5 0.1 0.3 11.5 0.1 2.6 2 1 1 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2116 PF09889.9 AET37909.1 - 0.47 10.5 1.9 1.2 9.1 1.9 1.7 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Allexi_40kDa PF05549.11 AET37909.1 - 0.51 9.8 7.8 1.5 8.3 0.5 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein OppC_N PF12911.7 AET37909.1 - 1 9.4 2.7 2 8.4 2.7 1.4 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C HOIP-UBA PF16678.5 AET37909.1 - 1.9 8.5 11.6 1.7 8.6 4.2 2.8 2 1 0 2 2 2 0 HOIP UBA domain pair DUF745 PF05335.13 AET37909.1 - 3.2 7.4 22.2 0.015 15.0 10.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) T2SSF PF00482.23 AET37909.1 - 5.2 7.0 10.3 0.66 9.9 4.9 2.3 2 2 1 3 3 3 0 Type II secretion system (T2SS), protein F SlyX PF04102.12 AET37909.1 - 6.2 7.5 18.5 0.085 13.5 6.1 2.7 2 1 0 2 2 2 0 SlyX DUF2115 PF09888.9 AET37909.1 - 6.4 7.3 8.1 1.7 9.2 0.2 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) DUF1664 PF07889.12 AET37909.1 - 9.5 6.3 11.5 0.88 9.6 3.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Fas_alpha_ACP PF18325.1 AET37910.1 - 9.7e-73 243.8 0.7 4.9e-72 241.6 0.0 2.3 2 0 0 2 2 2 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 AET37910.1 - 9.8e-67 224.5 1.1 1.6e-66 223.8 0.2 1.9 2 0 0 2 2 2 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 AET37910.1 - 3.8e-18 66.0 0.0 7e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 AET37910.1 - 1.2e-15 57.6 0.1 6.4e-15 55.3 0.0 2.3 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 AET37910.1 - 2.1e-11 43.9 0.0 4.7e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 AET37910.1 - 2.2e-07 30.5 0.0 5.6e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 AET37910.1 - 0.0018 18.2 0.0 0.0047 16.8 0.0 1.7 1 0 0 1 1 1 1 KR domain zf-C2H2 PF00096.26 AET37911.1 - 2.3e-10 40.3 8.3 5e-05 23.5 1.4 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AET37911.1 - 1.9e-09 37.5 6.5 3.1e-09 36.8 2.1 2.6 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 AET37911.1 - 0.0031 18.2 0.8 0.0031 18.2 0.8 3.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 AET37911.1 - 0.014 15.8 0.3 0.014 15.8 0.3 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 AET37911.1 - 0.016 15.2 0.0 0.016 15.2 0.0 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AET37911.1 - 0.067 13.5 0.5 0.067 13.5 0.5 3.4 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 AET37911.1 - 0.11 12.3 2.1 2.1 8.2 0.3 3.0 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2HE PF16278.5 AET37911.1 - 0.4 11.2 7.0 0.073 13.5 1.9 2.4 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_3rep PF18868.1 AET37911.1 - 1.8 9.2 11.3 0.21 12.2 0.3 3.0 3 0 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats Cauli_DNA-bind PF03310.13 AET37911.1 - 9 6.4 8.0 33 4.6 0.4 2.8 3 0 0 3 3 3 0 Caulimovirus DNA-binding protein Tuberin PF03542.16 AET37912.1 - 0.16 11.0 2.1 0.29 10.2 2.1 1.3 1 0 0 1 1 1 0 Tuberin Pex14_N PF04695.13 AET37912.1 - 1.4 9.6 12.2 0.2 12.3 4.7 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.8 AET37912.1 - 4 7.0 21.9 2.4 7.7 3.1 2.2 2 0 0 2 2 2 0 Spt20 family mRNA_triPase PF02940.15 AET37913.1 - 1.2e-64 218.1 1.2 1.7e-64 217.6 1.2 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Glycos_transf_2 PF00535.26 AET37914.1 - 5.2e-26 91.5 0.0 6.9e-26 91.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AET37914.1 - 2.9e-06 27.3 0.0 4.2e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 AET37914.1 - 0.0014 18.2 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 AET37914.1 - 0.0054 17.2 0.0 0.0094 16.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 ABC_tran PF00005.27 AET37916.1 - 2.6e-47 160.8 0.2 5.8e-26 91.6 0.0 4.5 3 2 0 3 3 2 2 ABC transporter AAA_21 PF13304.6 AET37916.1 - 7e-15 55.6 1.0 9.7e-05 22.3 0.2 4.5 3 1 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AET37916.1 - 4.1e-12 46.0 0.0 0.003 17.0 0.0 4.1 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain Chromo PF00385.24 AET37916.1 - 3.2e-09 36.6 3.4 6.5e-09 35.6 3.4 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_23 PF13476.6 AET37916.1 - 1.2e-08 35.8 0.5 0.00097 19.7 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 AET37916.1 - 3.4e-07 29.9 1.0 0.0045 16.7 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 AET37916.1 - 4.4e-07 30.0 0.1 0.0048 17.0 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AET37916.1 - 1e-06 28.7 0.3 0.0098 15.8 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 AET37916.1 - 9.8e-06 25.9 0.0 0.24 11.7 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 AET37916.1 - 8.6e-05 22.4 0.0 0.09 12.5 0.0 2.9 2 0 0 2 2 2 1 AAA ATPase domain DUF87 PF01935.17 AET37916.1 - 0.00026 21.2 2.0 0.1 12.7 0.1 3.6 3 0 0 3 3 3 1 Helicase HerA, central domain MeaB PF03308.16 AET37916.1 - 0.00041 19.4 0.3 0.83 8.6 0.1 2.7 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 AET37916.1 - 0.00069 20.0 0.0 1.4 9.3 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_18 PF13238.6 AET37916.1 - 0.00091 19.8 0.0 0.33 11.5 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 AET37916.1 - 0.0024 18.1 0.0 0.11 12.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 AET37916.1 - 0.0027 17.9 0.0 1.9 8.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 AET37916.1 - 0.0037 17.7 0.3 0.35 11.2 0.0 3.1 3 1 1 4 4 3 1 AAA ATPase domain NACHT PF05729.12 AET37916.1 - 0.0067 16.4 0.1 5.1 7.0 0.0 2.7 2 0 0 2 2 2 0 NACHT domain AAA_13 PF13166.6 AET37916.1 - 0.009 14.7 0.0 1.5 7.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 AET37916.1 - 0.0091 15.7 0.2 0.74 9.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AET37916.1 - 0.01 15.6 0.0 4 7.1 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 AET37916.1 - 0.013 16.0 0.0 4.6 7.7 0.0 3.4 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 AET37916.1 - 0.014 14.6 0.1 0.72 9.0 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain NTPase_1 PF03266.15 AET37916.1 - 0.014 15.3 0.1 4.6 7.1 0.1 3.2 3 0 0 3 3 3 0 NTPase AAA_27 PF13514.6 AET37916.1 - 0.017 14.8 0.0 8.1 6.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain DRIM PF07539.12 AET37916.1 - 0.048 12.0 5.6 0.31 9.3 5.3 2.4 2 1 0 2 2 2 0 Down-regulated in metastasis DUF3584 PF12128.8 AET37916.1 - 0.055 11.0 0.8 4.5 4.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DUF815 PF05673.13 AET37916.1 - 0.062 12.5 0.5 3.4 6.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Roc PF08477.13 AET37916.1 - 0.068 13.4 0.0 11 6.2 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 AET37916.1 - 0.076 13.1 1.7 0.79 9.8 0.0 3.1 4 0 0 4 4 3 0 Dynamin family Rad17 PF03215.15 AET37916.1 - 0.083 12.8 0.3 0.6 10.0 0.0 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain TsaE PF02367.17 AET37916.1 - 0.092 12.7 0.1 23 5.0 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 AET37916.1 - 0.11 12.0 0.1 12 5.4 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region PduV-EutP PF10662.9 AET37916.1 - 0.13 12.0 0.2 13 5.6 0.0 2.8 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation CLP1_P PF16575.5 AET37916.1 - 0.16 11.8 0.2 9.3 6.0 0.0 2.9 3 0 0 3 3 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop HEAT PF02985.22 AET37916.1 - 0.2 12.0 0.8 41 4.8 0.0 3.4 3 0 0 3 3 3 0 HEAT repeat cobW PF02492.19 AET37916.1 - 0.22 11.1 0.8 27 4.3 0.0 3.3 4 0 0 4 4 2 0 CobW/HypB/UreG, nucleotide-binding domain Thymidylate_kin PF02223.17 AET37916.1 - 1.1 8.9 0.0 1.1 8.9 0.0 2.9 4 0 0 4 4 2 0 Thymidylate kinase ABC_tran_Xtn PF12848.7 AET37916.1 - 2.4 8.2 8.2 0.12 12.4 0.6 2.5 2 0 0 2 2 2 0 ABC transporter MoCF_biosynth PF00994.24 AET37917.1 - 9.5e-28 96.7 0.0 1.5e-27 96.0 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain Polysacc_synt_4 PF04669.13 AET37918.1 - 9.6e-18 64.4 1.1 4.9e-16 58.8 1.1 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis ArdA PF07275.11 AET37918.1 - 0.071 13.7 0.9 0.21 12.2 0.9 1.7 1 1 0 1 1 1 0 Antirestriction protein (ArdA) NitrOD1 PF18549.1 AET37918.1 - 0.083 12.9 0.2 0.2 11.6 0.2 1.6 1 0 0 1 1 1 0 Nitrosopumilus output domain 1 Cation_efflux PF01545.21 AET37919.1 - 1.5e-49 168.4 11.5 1.9e-49 168.1 11.5 1.1 1 0 0 1 1 1 1 Cation efflux family GCR1_C PF12550.8 AET37922.1 - 1.5e-22 79.7 0.9 8.2e-22 77.3 1.3 2.2 2 0 0 2 2 1 1 Transcriptional activator of glycolytic enzymes PAT1 PF09770.9 AET37922.1 - 5.6e-05 21.7 40.9 9.7e-05 20.9 40.9 1.5 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 DUF4175 PF13779.6 AET37922.1 - 0.0017 16.4 46.1 0.0027 15.7 46.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) TFIIA PF03153.13 AET37922.1 - 0.0037 17.3 76.8 0.0037 17.3 76.8 1.9 1 1 1 2 2 2 1 Transcription factor IIA, alpha/beta subunit Rtf2 PF04641.12 AET37922.1 - 0.12 11.8 20.9 0.25 10.7 20.9 1.5 1 0 0 1 1 1 0 Rtf2 RING-finger Med19 PF10278.9 AET37922.1 - 0.17 11.8 14.6 0.4 10.6 14.6 1.6 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 RR_TM4-6 PF06459.12 AET37922.1 - 0.94 9.3 31.3 0.033 14.0 22.5 2.5 3 0 0 3 3 3 0 Ryanodine Receptor TM 4-6 Borrelia_P83 PF05262.11 AET37922.1 - 1.1 7.7 25.8 1.6 7.1 25.8 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein SID-1_RNA_chan PF13965.6 AET37922.1 - 1.1 7.5 9.8 1.6 7.0 9.8 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Otopetrin PF03189.13 AET37922.1 - 1.8 7.3 11.3 3.1 6.5 11.3 1.4 1 0 0 1 1 1 0 Otopetrin DUF4045 PF13254.6 AET37922.1 - 4.2 6.9 35.8 0.16 11.6 27.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) Band_3_cyto PF07565.13 AET37922.1 - 6.6 6.5 25.5 19 4.9 25.5 1.8 1 0 0 1 1 1 0 Band 3 cytoplasmic domain CDC45 PF02724.14 AET37922.1 - 6.7 4.9 28.9 0.94 7.7 20.8 2.1 2 0 0 2 2 2 0 CDC45-like protein DUF4746 PF15928.5 AET37922.1 - 9 5.6 26.9 3.8 6.9 19.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) UPF0061 PF02696.14 AET37923.1 - 8.2e-151 502.9 0.1 9.7e-151 502.7 0.1 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Lon_C PF05362.13 AET37925.1 - 4.7e-39 134.1 0.0 8e-39 133.3 0.0 1.3 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 AET37925.1 - 4.3e-19 69.3 0.0 9.4e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AET37925.1 - 1.9e-08 34.4 0.0 1.2e-07 31.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 AET37925.1 - 2e-05 24.4 0.0 4.7e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase LON_substr_bdg PF02190.16 AET37925.1 - 3.2e-05 23.9 0.4 8.7e-05 22.5 0.4 1.8 1 1 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA_16 PF13191.6 AET37925.1 - 9.2e-05 22.9 0.0 0.00024 21.5 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 AET37925.1 - 0.00017 21.3 0.1 0.0022 17.7 0.0 2.5 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 AET37925.1 - 0.001 18.9 0.0 0.0025 17.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SMC_N PF02463.19 AET37925.1 - 0.0027 17.2 0.0 0.067 12.6 0.0 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_2 PF07724.14 AET37925.1 - 0.0029 17.7 0.0 0.011 15.8 0.0 1.9 2 1 0 2 2 1 1 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 AET37925.1 - 0.015 15.7 0.0 0.099 13.0 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_22 PF13401.6 AET37925.1 - 0.017 15.4 0.0 0.21 11.9 0.0 2.4 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 AET37925.1 - 0.023 14.6 0.1 0.081 12.8 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase Mg_chelatase PF01078.21 AET37925.1 - 0.038 13.4 0.0 0.19 11.1 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 AET37925.1 - 0.061 12.6 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_7 PF12775.7 AET37925.1 - 0.093 12.2 0.1 0.65 9.5 0.0 2.3 3 0 0 3 3 3 0 P-loop containing dynein motor region Rad17 PF03215.15 AET37925.1 - 0.097 12.6 0.0 0.26 11.2 0.0 1.8 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_33 PF13671.6 AET37925.1 - 0.15 12.3 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 AET37925.1 - 0.15 12.6 0.0 0.5 10.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 AET37925.1 - 0.18 11.5 0.1 0.94 9.2 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein TRP PF06011.12 AET37926.1 - 1.4e-153 511.7 34.8 1.7e-153 511.4 34.8 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 AET37926.1 - 2.1e-41 141.6 0.1 3.3e-41 140.9 0.1 1.3 1 0 0 1 1 1 1 ML-like domain TMEMspv1-c74-12 PF11044.8 AET37926.1 - 0.0032 17.4 0.0 0.0032 17.4 0.0 3.5 4 0 0 4 4 4 1 Plectrovirus spv1-c74 ORF 12 transmembrane protein FtsJ PF01728.19 AET37928.1 - 3e-51 174.0 0.0 8.7e-51 172.5 0.0 1.6 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 AET37928.1 - 0.0013 18.5 0.0 0.14 12.0 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 AET37928.1 - 0.0038 17.1 0.0 0.01 15.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AET37928.1 - 0.0061 17.2 0.0 0.66 10.7 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain Ribosomal_L1 PF00687.21 AET37929.1 - 3.1e-41 141.4 0.8 3.9e-41 141.0 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Cyclin PF08613.11 AET37930.1 - 8.3e-14 52.3 0.5 2e-13 51.0 0.4 1.9 1 1 0 1 1 1 1 Cyclin Ste5_C PF12194.8 AET37930.1 - 0.017 15.1 0.1 0.052 13.5 0.1 1.8 1 1 0 1 1 1 0 Protein kinase Fus3-binding Arf PF00025.21 AET37931.1 - 3e-65 218.9 0.0 3.4e-65 218.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 AET37931.1 - 3.7e-09 36.2 0.4 5.4e-06 25.8 0.0 2.6 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 AET37931.1 - 1.6e-07 31.0 0.0 2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 AET37931.1 - 3.5e-07 29.8 0.0 4.6e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 AET37931.1 - 1.5e-06 28.4 0.0 4.7e-06 26.8 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 AET37931.1 - 9.1e-06 25.7 0.0 1.2e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 AET37931.1 - 0.00021 20.7 0.0 0.00024 20.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AET37931.1 - 0.054 13.0 0.0 0.72 9.4 0.0 2.0 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 AET37931.1 - 0.15 11.8 0.0 0.46 10.2 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation WAC_Acf1_DNA_bd PF10537.9 AET37932.1 - 4.9e-34 116.9 0.5 4.9e-34 116.9 0.5 2.2 2 0 0 2 2 2 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 AET37932.1 - 3.7e-09 36.9 0.0 8e-08 32.7 0.0 3.2 2 1 0 2 2 2 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 AET37932.1 - 1.1e-07 32.0 1.1 4.8e-06 26.8 0.2 2.7 2 0 0 2 2 2 1 DDT domain MEA1 PF06910.11 AET37932.1 - 0.42 11.2 0.0 0.42 11.2 0.0 3.3 3 0 0 3 3 3 0 Male enhanced antigen 1 (MEA1) Ubiq_cyt_C_chap PF03981.12 AET37933.1 - 5.6e-42 143.2 0.2 8.6e-42 142.6 0.2 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone HK PF02110.15 AET37934.1 - 8e-66 221.9 0.8 1.3e-65 221.2 0.8 1.3 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 AET37934.1 - 2.8e-57 193.0 0.0 4.2e-57 192.4 0.0 1.3 1 0 0 1 1 1 1 Thiamine monophosphate synthase Carb_kinase PF01256.17 AET37934.1 - 0.072 12.5 0.2 8.6 5.7 0.0 2.4 2 0 0 2 2 2 0 Carbohydrate kinase LRR_9 PF14580.6 AET37935.1 - 1e-09 38.2 0.2 2.1e-09 37.1 0.1 1.6 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 AET37935.1 - 0.002 18.5 13.4 0.057 13.9 2.0 3.6 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) DUF4277 PF14104.6 AET37935.1 - 0.11 12.8 0.9 1.8 9.0 0.1 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4277) BAH PF01426.18 AET37936.1 - 6.4e-15 55.1 0.1 2e-14 53.5 0.1 1.8 1 0 0 1 1 1 1 BAH domain zf-HC5HC2H_2 PF13832.6 AET37936.1 - 3.7e-13 49.6 1.5 3.7e-13 49.6 1.5 5.5 5 0 0 5 5 5 2 PHD-zinc-finger like domain PHD PF00628.29 AET37936.1 - 2.3e-11 43.4 56.4 6.2e-08 32.4 8.8 6.9 6 1 1 7 7 7 3 PHD-finger zf-HC5HC2H PF13771.6 AET37936.1 - 1.3e-08 35.0 2.4 1.3e-08 35.0 2.4 6.0 6 0 0 6 6 6 2 PHD-like zinc-binding domain PHD_2 PF13831.6 AET37936.1 - 3.3e-07 29.7 20.6 0.00024 20.6 3.0 5.5 4 0 0 4 4 4 3 PHD-finger Myb_DNA-binding PF00249.31 AET37936.1 - 0.0065 16.6 0.0 0.016 15.4 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain PSY3 PF16836.5 AET37936.1 - 0.02 14.4 5.7 0.015 14.9 3.4 1.9 1 1 1 2 2 2 0 Shu complex component Psy3, DNA-binding description DUF16 PF01519.16 AET37936.1 - 0.11 13.0 5.1 4.5 7.8 2.3 3.1 2 0 0 2 2 2 0 Protein of unknown function DUF16 C1_1 PF00130.22 AET37936.1 - 0.25 11.2 48.7 0.16 11.9 5.4 6.1 6 0 0 6 6 6 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Med21 PF11221.8 AET37936.1 - 3.6 7.8 8.5 0.29 11.4 1.7 2.4 2 0 0 2 2 2 0 Subunit 21 of Mediator complex mRNA_cap_enzyme PF01331.19 AET37937.1 - 2.7e-60 203.5 0.0 4e-60 203.0 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 AET37937.1 - 2e-32 112.1 0.2 3.5e-32 111.3 0.2 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 AET37937.1 - 2.3e-07 30.6 0.0 2.4e-05 24.1 0.0 2.4 1 1 0 1 1 1 1 ATP dependent DNA ligase domain DAP3 PF10236.9 AET37938.1 - 4.5e-82 275.7 0.1 5.7e-82 275.4 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 AET37938.1 - 0.0005 20.5 0.0 0.0009 19.7 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AET37938.1 - 0.0012 19.1 0.1 0.0066 16.7 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_29 PF13555.6 AET37938.1 - 0.0018 18.0 0.1 0.0051 16.5 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_24 PF13479.6 AET37938.1 - 0.0037 17.0 0.0 0.0068 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 AET37938.1 - 0.0048 16.8 0.1 0.011 15.7 0.1 1.5 1 0 0 1 1 1 1 NTPase AAA_33 PF13671.6 AET37938.1 - 0.0082 16.3 0.0 0.034 14.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 AET37938.1 - 0.014 15.8 0.1 0.043 14.2 0.0 1.9 2 0 0 2 2 1 0 RNA helicase ATPase_2 PF01637.18 AET37938.1 - 0.02 14.8 0.9 0.46 10.4 0.1 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 AET37938.1 - 0.025 14.3 0.1 0.11 12.2 0.0 2.1 3 0 0 3 3 3 0 IstB-like ATP binding protein RsgA_GTPase PF03193.16 AET37938.1 - 0.026 14.4 0.0 0.079 12.9 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 AET37938.1 - 0.04 13.6 0.2 0.11 12.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 AET37938.1 - 0.041 12.9 0.0 0.087 11.8 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DNA_pol3_a_NI PF14480.6 AET37938.1 - 0.054 13.5 1.6 0.25 11.3 0.4 2.5 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus I NACHT PF05729.12 AET37938.1 - 0.072 13.0 0.5 0.21 11.5 0.2 2.0 2 0 0 2 2 1 0 NACHT domain ABC_tran PF00005.27 AET37938.1 - 0.097 13.2 0.0 0.24 11.9 0.0 1.6 1 0 0 1 1 1 0 ABC transporter NB-ARC PF00931.22 AET37938.1 - 0.11 11.7 0.0 0.22 10.6 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_5 PF07728.14 AET37938.1 - 0.11 12.5 0.0 0.3 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 AET37938.1 - 0.13 12.6 0.1 0.25 11.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 AET37938.1 - 0.2 10.7 0.0 0.33 10.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein PseudoU_synth_1 PF01416.20 AET37939.1 - 3.5e-11 43.5 0.0 5.2e-10 39.8 0.0 2.4 2 0 0 2 2 2 1 tRNA pseudouridine synthase UPF0113_N PF17833.1 AET37940.1 - 3e-27 95.0 0.0 4.3e-27 94.5 0.0 1.2 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 AET37940.1 - 1e-24 86.6 0.0 2.1e-24 85.6 0.0 1.5 1 0 0 1 1 1 1 UPF0113 PUA domain PUA PF01472.20 AET37940.1 - 0.13 12.3 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 PUA domain SRP72 PF08492.12 AET37941.1 - 4.5e-12 46.2 0.3 4.5e-12 46.2 0.3 2.8 3 0 0 3 3 1 1 SRP72 RNA-binding domain TPR_2 PF07719.17 AET37941.1 - 4.1e-06 26.5 4.6 0.37 11.0 0.0 4.8 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 AET37941.1 - 9.5e-05 22.9 0.0 26 6.0 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 AET37941.1 - 0.00015 22.2 3.8 27 5.4 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 AET37941.1 - 0.0018 18.1 0.6 5.7 7.2 0.0 4.6 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 AET37941.1 - 0.0019 18.4 2.5 7.1 7.0 0.1 4.1 4 1 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 AET37941.1 - 0.0028 17.4 1.9 7.8 6.5 0.0 4.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 AET37941.1 - 0.015 14.9 0.7 1.4 8.7 0.0 3.0 2 0 0 2 2 2 0 TPR repeat TPR_MalT PF17874.1 AET37941.1 - 0.022 14.2 0.1 0.051 12.9 0.1 1.6 1 0 0 1 1 1 0 MalT-like TPR region SRP_TPR_like PF17004.5 AET37941.1 - 0.029 14.4 8.9 0.053 13.5 2.4 4.0 3 2 0 3 3 3 0 Putative TPR-like repeat TPR_10 PF13374.6 AET37941.1 - 0.033 14.1 0.5 0.85 9.6 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 AET37941.1 - 0.048 13.9 0.8 2 8.7 0.2 3.1 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 AET37941.1 - 0.33 11.3 9.3 9.9 6.7 0.0 4.7 5 1 0 5 5 5 0 Tetratricopeptide repeat DEAD PF00270.29 AET37942.1 - 2.2e-31 109.0 0.1 4.5e-31 108.0 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET37942.1 - 4.8e-16 59.1 1.4 2.9e-15 56.6 0.3 2.7 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET37942.1 - 5.4e-10 39.5 0.1 2.6e-09 37.3 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 AET37942.1 - 0.033 14.5 1.4 1.2 9.4 0.8 3.0 2 1 0 2 2 2 0 AAA domain Pkinase PF00069.25 AET37943.1 - 8.5e-71 238.4 0.1 1.3e-70 237.7 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET37943.1 - 4.8e-44 150.6 0.0 6.6e-44 150.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET37943.1 - 0.0015 17.9 0.0 0.0029 17.0 0.0 1.5 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 AET37943.1 - 0.03 13.9 0.1 0.059 13.0 0.1 1.5 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 AET37943.1 - 0.061 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1461 PF07314.11 AET37943.1 - 0.078 12.9 0.1 0.13 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) Pkinase_fungal PF17667.1 AET37943.1 - 0.081 11.7 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase SET PF00856.28 AET37944.1 - 1.8e-10 41.5 0.0 3.5e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 SET domain Wyosine_form PF08608.12 AET37945.1 - 2.2e-22 79.1 0.0 4.6e-22 78.1 0.0 1.6 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 AET37945.1 - 1.1e-19 71.5 0.0 2.4e-19 70.3 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Flavodoxin_1 PF00258.25 AET37945.1 - 1.1e-12 48.4 0.0 2.4e-12 47.2 0.0 1.7 1 0 0 1 1 1 1 Flavodoxin Guanylate_kin PF00625.21 AET37945.1 - 0.043 13.5 0.1 0.78 9.4 0.0 2.2 2 0 0 2 2 2 0 Guanylate kinase AAA_23 PF13476.6 AET37945.1 - 0.072 13.6 0.1 0.14 12.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain Glycos_transf_1 PF00534.20 AET37946.1 - 6.9e-33 113.6 0.0 2.8e-32 111.6 0.0 2.0 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 AET37946.1 - 9.8e-14 51.7 0.0 1.9e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 AET37946.1 - 3.2e-09 37.3 0.0 1.8e-08 34.9 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 AET37946.1 - 0.0069 16.8 0.0 0.014 15.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_5 PF16994.5 AET37946.1 - 0.02 14.5 0.0 0.15 11.7 0.0 2.2 2 0 0 2 2 2 0 Glycosyl-transferase family 4 SCA7 PF08313.12 AET37947.1 - 4.5e-30 103.4 1.1 2e-29 101.3 1.1 2.2 1 0 0 1 1 1 1 SCA7, zinc-binding domain zf_C2H2_13 PF18508.1 AET37947.1 - 2.9e-13 49.1 0.9 6.2e-13 48.1 0.4 1.8 2 0 0 2 2 2 1 Zinc finger domain Sgf11 PF08209.11 AET37947.1 - 0.17 11.5 0.5 0.35 10.5 0.5 1.5 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) GDPD PF03009.17 AET37948.1 - 3e-30 105.8 0.0 5.4e-30 105.0 0.0 1.4 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 AET37948.1 - 5.6e-06 26.6 0.1 9.5e-05 22.7 0.0 2.9 3 0 0 3 3 3 1 Glycerophosphoryl diester phosphodiesterase family GLEYA PF10528.9 AET37949.1 - 1.3e-22 80.0 0.8 1.3e-22 80.0 0.8 2.1 3 0 0 3 3 3 1 GLEYA domain PA14 PF07691.12 AET37949.1 - 3.1e-10 40.1 0.0 5.3e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 PA14 domain Flocculin PF00624.18 AET37949.1 - 0.045 14.0 14.5 0.045 14.0 14.5 2.1 2 0 0 2 2 2 0 Flocculin repeat C1q PF00386.21 AET37949.1 - 0.062 13.5 0.1 0.16 12.2 0.1 1.7 1 0 0 1 1 1 0 C1q domain DUF5010_C PF18099.1 AET37949.1 - 0.087 13.0 0.3 0.24 11.6 0.0 1.8 2 0 0 2 2 2 0 DUF5010 C-terminal domain GLEYA PF10528.9 AET37950.1 - 1e-22 80.3 0.8 1e-22 80.3 0.8 1.8 2 0 0 2 2 2 1 GLEYA domain PA14 PF07691.12 AET37950.1 - 2.8e-10 40.2 0.0 4.1e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 PA14 domain C1q PF00386.21 AET37950.1 - 0.066 13.4 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 C1q domain DUF5010_C PF18099.1 AET37950.1 - 0.11 12.6 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 DUF5010 C-terminal domain Pkinase PF00069.25 AET37951.1 - 3.4e-23 82.3 0.0 7.2e-23 81.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET37951.1 - 3e-14 53.0 0.0 7.3e-14 51.7 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AET37951.1 - 4e-08 32.5 0.1 4e-08 32.5 0.1 2.7 2 1 0 3 3 3 1 Fungal protein kinase APH PF01636.23 AET37951.1 - 0.0028 17.6 0.4 0.081 12.8 0.0 2.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family ABC1 PF03109.16 AET37951.1 - 0.04 14.1 0.0 0.86 9.8 0.0 2.6 2 0 0 2 2 2 0 ABC1 family Pkinase PF00069.25 AET37952.1 - 5.8e-71 238.9 0.0 7.1e-71 238.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET37952.1 - 2.2e-39 135.3 0.0 2.9e-39 134.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET37952.1 - 1.5e-05 24.5 0.0 3.2e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.9 AET37952.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.5 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Haspin_kinase PF12330.8 AET37952.1 - 0.17 10.8 0.5 0.34 9.8 0.5 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Ribosomal_L12 PF00542.19 AET37953.1 - 5.7e-23 81.0 9.2 6.1e-22 77.8 7.7 2.3 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 AET37953.1 - 4.7e-14 51.8 1.7 1e-12 47.5 0.1 2.3 2 0 0 2 2 2 1 Ribosomal protein L7/L12 dimerisation domain Ribosomal_60s PF00428.19 AET37953.1 - 0.012 16.2 2.5 0.012 16.2 2.5 2.2 1 1 1 2 2 2 0 60s Acidic ribosomal protein RNA_POL_M_15KD PF02150.16 AET37954.1 - 8.1e-16 57.6 3.4 8.1e-16 57.6 3.4 2.9 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 AET37954.1 - 2.7e-14 52.7 15.0 4.4e-14 52.0 1.8 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) DUF2387 PF09526.10 AET37954.1 - 0.0036 17.4 4.4 0.68 10.1 0.5 2.4 2 1 0 2 2 2 2 Probable metal-binding protein (DUF2387) zinc_ribbon_10 PF10058.9 AET37954.1 - 0.007 16.1 4.6 0.091 12.5 0.1 2.4 2 0 0 2 2 2 1 Predicted integral membrane zinc-ribbon metal-binding protein DZR PF12773.7 AET37954.1 - 0.11 12.5 7.5 1.2 9.3 0.5 2.6 2 1 0 2 2 2 0 Double zinc ribbon zf-UBP PF02148.19 AET37954.1 - 0.14 12.5 4.0 0.53 10.7 0.5 2.3 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein Zn_Tnp_IS1595 PF12760.7 AET37954.1 - 0.33 11.0 11.1 0.95 9.5 2.4 2.6 2 1 0 2 2 2 0 Transposase zinc-ribbon domain HypA PF01155.19 AET37954.1 - 0.77 9.8 6.2 1.5 8.8 3.0 2.7 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Lar_restr_allev PF14354.6 AET37954.1 - 1.1 9.6 6.6 0.5 10.8 0.3 2.6 2 1 0 2 2 2 0 Restriction alleviation protein Lar Zn-ribbon_8 PF09723.10 AET37954.1 - 2.1 8.5 12.3 2.5 8.3 0.1 3.6 3 1 1 4 4 4 0 Zinc ribbon domain Cytochrome_C7 PF14522.6 AET37954.1 - 6.6 6.8 9.0 76 3.4 9.0 2.5 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c AFT PF08731.11 AET37955.1 - 4.9e-47 158.9 1.0 3.2e-45 153.1 0.0 2.6 2 0 0 2 2 2 1 Transcription factor AFT DBD_Tnp_Mut PF03108.15 AET37955.1 - 0.055 13.5 0.2 17 5.5 0.0 2.5 2 0 0 2 2 2 0 MuDR family transposase COX16 PF14138.6 AET37955.1 - 0.069 13.7 0.3 3.7 8.1 0.0 2.6 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 Menin PF05053.13 AET37955.1 - 1.5 7.1 7.1 2.5 6.4 7.1 1.3 1 0 0 1 1 1 0 Menin PQQ_3 PF13570.6 AET37956.1 - 0.0077 16.7 3.5 16 6.1 0.5 4.5 3 1 0 3 3 3 1 PQQ-like domain eIF2A PF08662.11 AET37956.1 - 0.048 13.5 0.0 0.091 12.6 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A US22 PF02393.16 AET37956.1 - 0.071 13.4 0.4 0.21 11.9 0.4 1.8 1 1 0 1 1 1 0 US22 like MMS1_N PF10433.9 AET37956.1 - 0.13 10.9 0.0 0.85 8.2 0.0 1.9 2 0 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term WDCP PF15390.6 AET37956.1 - 0.14 10.5 0.0 0.2 10.0 0.0 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family HSF_DNA-bind PF00447.17 AET37957.1 - 2.2e-32 111.5 2.3 2.2e-32 111.5 2.3 1.7 2 0 0 2 2 2 1 HSF-type DNA-binding MPS2 PF17060.5 AET37958.1 - 1.1e-32 113.7 11.8 1e-16 61.2 6.4 2.3 1 1 1 2 2 2 2 Monopolar spindle protein 2 Mod_r PF07200.13 AET37958.1 - 0.04 14.0 4.5 0.097 12.8 4.1 1.8 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein EF-hand_7 PF13499.6 AET37958.1 - 0.052 14.0 1.1 0.076 13.5 0.2 2.0 2 1 0 2 2 2 0 EF-hand domain pair DUF1771 PF08590.10 AET37959.1 - 6.7e-21 74.4 13.1 1.1e-20 73.7 13.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.21 AET37959.1 - 8.7e-12 45.2 0.6 2.8e-11 43.6 0.0 2.1 2 1 0 2 2 2 1 Smr domain Seryl_tRNA_N PF02403.22 AET37959.1 - 0.12 12.6 4.6 0.21 11.8 4.6 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain HemY_N PF07219.13 AET37959.1 - 0.5 10.6 4.2 0.89 9.8 4.2 1.3 1 0 0 1 1 1 0 HemY protein N-terminus DUF4407 PF14362.6 AET37959.1 - 1 8.7 6.2 1.3 8.3 6.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2203 PF09969.9 AET37959.1 - 2.2 9.0 5.7 9.1 7.0 5.7 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF4337 PF14235.6 AET37959.1 - 3.9 7.6 8.4 5.9 7.0 8.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) PTS_IIA PF02255.16 AET37959.1 - 8 6.6 7.1 3.8 7.6 3.2 2.1 1 1 1 2 2 2 0 PTS system, Lactose/Cellobiose specific IIA subunit Ribosomal_L30_N PF08079.12 AET37960.1 - 3.6e-20 72.0 16.9 7.2e-20 71.0 16.9 1.5 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 AET37960.1 - 7.3e-19 67.4 2.0 1.5e-18 66.4 2.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e AA_permease_2 PF13520.6 AET37961.1 - 3.7e-51 174.3 43.9 4.3e-51 174.1 43.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AET37961.1 - 9e-20 70.7 40.4 1.4e-19 70.1 40.4 1.3 1 1 0 1 1 1 1 Amino acid permease Herpes_UL20 PF04544.12 AET37961.1 - 0.88 9.9 11.8 3.3 8.0 2.1 3.0 2 1 0 2 2 2 0 Herpesvirus egress protein UL20 DEAD PF00270.29 AET37962.1 - 2.5e-52 177.2 0.1 1.3e-51 174.9 0.0 2.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET37962.1 - 2e-35 121.5 0.7 1.4e-31 109.1 0.1 3.3 2 1 1 3 3 3 2 Helicase conserved C-terminal domain UTP25 PF06862.12 AET37962.1 - 0.023 13.5 0.2 0.023 13.5 0.2 3.4 3 1 1 4 4 3 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 HTH_7 PF02796.15 AET37962.1 - 0.037 14.1 0.0 0.099 12.7 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase DDHD PF02862.17 AET37962.1 - 0.045 13.9 4.4 0.1 12.8 4.4 1.6 1 0 0 1 1 1 0 DDHD domain CMS1 PF14617.6 AET37962.1 - 0.085 12.2 0.0 0.085 12.2 0.0 3.3 2 1 0 2 2 1 0 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 AET37962.1 - 0.2 11.9 1.1 1.8 8.8 1.1 2.4 1 1 0 1 1 1 0 AAA domain CPSF100_C PF13299.6 AET37962.1 - 0.73 10.0 14.7 2 8.6 13.4 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF3807 PF12720.7 AET37962.1 - 2.3 8.5 24.8 4.5 7.5 24.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) TMEM51 PF15345.6 AET37962.1 - 2.4 8.0 9.9 4.9 6.9 9.9 1.5 1 0 0 1 1 1 0 Transmembrane protein 51 MMU163 PF17119.5 AET37962.1 - 3.5 6.7 14.0 5.8 6.0 14.0 1.3 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis RPN2_C PF18004.1 AET37962.1 - 3.6 7.5 31.5 8.5 6.3 31.5 1.6 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Rtf2 PF04641.12 AET37962.1 - 4.7 6.5 28.2 10 5.4 28.2 1.6 1 0 0 1 1 1 0 Rtf2 RING-finger Tim54 PF11711.8 AET37962.1 - 5.3 5.7 19.6 8.9 5.0 19.6 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NPR3 PF03666.13 AET37962.1 - 7.3 5.3 21.2 12 4.5 21.2 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CobT PF06213.12 AET37962.1 - 9.4 5.5 17.3 15 4.9 17.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FA_desaturase PF00487.24 AET37963.1 - 2.6e-30 106.1 20.4 3.6e-30 105.6 20.4 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 AET37963.1 - 1.5e-11 44.3 0.0 4.6e-11 42.7 0.0 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DUF3821 PF12863.7 AET37963.1 - 0.021 14.7 0.5 6.9 6.5 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3821) TLD PF07534.16 AET37964.1 - 9.2e-28 97.2 0.0 1.5e-26 93.3 0.0 2.1 1 1 0 1 1 1 1 TLD KxDL PF10241.9 AET37965.1 - 1.7e-22 79.5 0.2 2.4e-22 79.0 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein Sec34 PF04136.15 AET37965.1 - 0.011 15.6 0.2 0.018 15.0 0.2 1.4 1 0 0 1 1 1 0 Sec34-like family Adaptin_N PF01602.20 AET37966.1 - 6.8e-112 374.7 17.8 9.6e-112 374.2 17.8 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 AET37966.1 - 3.5e-10 40.2 8.8 6.4e-10 39.3 0.5 3.1 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 AET37966.1 - 0.00015 21.7 0.4 25 5.5 0.0 5.5 5 0 0 5 5 5 0 HEAT repeat HEAT_2 PF13646.6 AET37966.1 - 0.00078 19.8 0.1 0.14 12.5 0.0 3.6 3 1 0 3 3 3 1 HEAT repeats Cnd3 PF12719.7 AET37966.1 - 0.0048 16.1 4.0 0.028 13.6 0.2 3.3 2 1 1 3 3 3 1 Nuclear condensing complex subunits, C-term domain DBD_HTH PF18430.1 AET37966.1 - 0.01 15.6 0.1 0.03 14.1 0.1 1.8 1 0 0 1 1 1 0 Putative DNA-binding domain RTP1_C1 PF10363.9 AET37966.1 - 0.043 14.0 1.6 12 6.1 0.1 3.5 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.7 AET37966.1 - 0.39 11.3 5.2 0.19 12.3 0.2 3.1 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Rad9 PF04139.13 AET37967.1 - 1.4e-10 41.1 0.4 1.2e-05 24.9 0.1 2.3 2 1 0 2 2 2 2 Rad9 Hus1 PF04005.12 AET37967.1 - 0.013 14.6 0.8 0.049 12.7 0.2 2.1 2 0 0 2 2 2 0 Hus1-like protein MPC PF03650.13 AET37968.1 - 1.1e-39 134.9 0.0 1.4e-39 134.7 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers KCH PF16944.5 AET37968.1 - 0.049 13.4 0.0 0.06 13.1 0.0 1.1 1 0 0 1 1 1 0 Fungal potassium channel NUFIP1 PF10453.9 AET37969.1 - 1.1e-16 60.4 3.7 2.5e-16 59.3 3.7 1.6 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) DUF4449 PF14613.6 AET37970.1 - 0.0073 16.4 1.1 0.15 12.1 0.8 2.0 1 1 0 2 2 2 2 Protein of unknown function (DUF4449) FHA PF00498.26 AET37971.1 - 7e-06 26.3 0.1 2e-05 24.9 0.1 1.7 1 0 0 1 1 1 1 FHA domain Zip PF02535.22 AET37971.1 - 2.8 7.1 7.2 5.2 6.2 7.2 1.5 1 1 0 1 1 1 0 ZIP Zinc transporter MINDY_DUB PF04424.13 AET37972.1 - 2.3e-28 98.6 0.0 4.4e-28 97.7 0.0 1.5 1 0 0 1 1 1 1 MINDY deubiquitinase RRM_1 PF00076.22 AET37973.1 - 4.3e-09 36.1 0.4 9.3e-09 35.0 0.4 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AET37973.1 - 1.8e-06 27.6 0.0 1.7e-05 24.4 0.0 2.6 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) COA2 PF17051.5 AET37974.1 - 4.3e-17 61.9 0.1 4.7e-17 61.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome C oxidase assembly factor 2 NOPS PF08075.11 AET37974.1 - 0.036 14.2 0.1 0.045 13.9 0.1 1.1 1 0 0 1 1 1 0 NOPS (NUC059) domain MBOAT PF03062.19 AET37975.1 - 2.3e-69 234.4 22.6 5.6e-69 233.1 21.4 1.9 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family SNase PF00565.17 AET37976.1 - 6.9e-20 71.5 0.0 1.4e-19 70.6 0.0 1.4 1 0 0 1 1 1 1 Staphylococcal nuclease homologue UQ_con PF00179.26 AET37977.1 - 1.4e-18 66.9 0.0 1.6e-18 66.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 AET37977.1 - 0.024 14.5 0.0 0.031 14.1 0.0 1.2 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 AET37977.1 - 0.025 14.9 0.0 0.027 14.8 0.0 1.2 1 0 0 1 1 1 0 RWD domain NAD_kinase PF01513.21 AET37978.1 - 1.7e-52 178.4 0.0 2.3e-52 178.0 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 AET37978.1 - 0.016 14.9 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain DUF1116 PF06545.11 AET37978.1 - 0.054 12.9 0.0 0.083 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1116) MF_alpha PF04648.12 AET37979.1 - 2.1e-28 97.4 34.3 9.8e-07 28.8 2.8 4.2 4 0 0 4 4 4 4 Yeast mating factor alpha hormone MF_alpha_N PF05436.11 AET37979.1 - 7.4e-27 93.1 0.3 9.6e-27 92.7 0.3 1.1 1 0 0 1 1 1 1 Mating factor alpha precursor N-terminus Secapin PF17521.2 AET37979.1 - 0.014 15.1 0.0 53 3.7 0.0 3.2 3 0 0 3 3 3 0 Honey bee peptides DUF5550 PF17704.1 AET37979.1 - 0.021 14.9 0.4 23 5.1 0.0 3.2 1 1 3 4 4 4 0 Family of unknown function (DUF5550) Cu_amine_oxidN2 PF02727.16 AET37979.1 - 0.024 14.9 4.8 22 5.4 0.1 3.3 1 1 2 3 3 3 0 Copper amine oxidase, N2 domain zf-H2C2 PF09337.10 AET37979.1 - 0.031 14.5 0.3 1.3e+02 2.9 0.0 3.9 4 0 0 4 4 4 0 H2C2 zinc finger NAPRTase PF04095.16 AET37979.1 - 0.084 12.5 1.7 16 5.0 0.1 3.0 1 1 2 3 3 3 0 Nicotinate phosphoribosyltransferase (NAPRTase) family DUF287 PF03384.14 AET37979.1 - 0.17 12.3 5.2 40 4.7 0.0 3.9 1 1 3 4 4 4 0 Drosophila protein of unknown function, DUF287 RRM_1 PF00076.22 AET37980.1 - 6.7e-28 96.3 2.6 1.3e-06 28.1 0.1 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AET37980.1 - 4.2e-12 45.8 0.1 0.014 15.2 0.0 4.4 4 0 0 4 4 4 4 Occluded RNA-recognition motif RRM_5 PF13893.6 AET37980.1 - 0.00033 20.2 0.1 1.9 8.1 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 AET37980.1 - 0.027 14.5 0.1 1.3 9.1 0.0 2.7 3 0 0 3 3 3 0 RNA binding motif Nup35_RRM_2 PF14605.6 AET37980.1 - 0.15 12.1 0.0 4.1 7.5 0.0 2.9 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif NYD-SP28 PF14772.6 AET37981.1 - 0.041 13.9 0.6 0.084 12.9 0.5 1.5 2 0 0 2 2 2 0 Sperm tail ParA PF10609.9 AET37982.1 - 1e-91 306.8 0.0 1.2e-91 306.6 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 AET37982.1 - 1.4e-09 38.1 0.0 3.3e-09 36.9 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 AET37982.1 - 1.1e-07 32.0 0.2 1.1e-06 28.7 0.2 2.0 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 AET37982.1 - 7.5e-05 22.1 0.0 0.00012 21.5 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 AET37982.1 - 0.00041 19.6 2.4 0.0026 17.0 0.4 2.5 1 1 1 3 3 3 1 Anion-transporting ATPase RsgA_GTPase PF03193.16 AET37982.1 - 0.0046 16.9 0.1 0.013 15.4 0.1 1.7 1 0 0 1 1 1 1 RsgA GTPase Rad17 PF03215.15 AET37982.1 - 0.0087 16.0 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain CBP_BcsQ PF06564.12 AET37982.1 - 0.019 14.5 0.1 0.048 13.1 0.1 1.8 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ AAA_25 PF13481.6 AET37982.1 - 0.067 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Fer4_NifH PF00142.18 AET37982.1 - 0.095 12.1 0.0 1.2 8.6 0.0 2.4 2 1 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_15 PF13175.6 AET37982.1 - 0.19 11.4 0.0 0.23 11.1 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 AET37982.1 - 0.21 10.8 0.0 0.32 10.2 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain zf_Rg PF17915.1 AET37982.1 - 4.2 6.9 7.1 3.5 7.1 0.1 2.4 2 0 0 2 2 2 0 Reverse gyrase zinc finger Nucleoporin2 PF04096.14 AET37983.1 - 1.1e-45 155.4 0.0 2.1e-45 154.5 0.0 1.5 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nup96 PF12110.8 AET37983.1 - 6.4e-40 137.1 0.1 1.9e-39 135.5 0.1 1.8 1 1 0 1 1 1 1 Nuclear protein 96 Nucleoporin_FG PF13634.6 AET37983.1 - 3.1e-06 27.9 68.0 1.3e-05 25.9 26.7 4.5 1 1 3 4 4 4 4 Nucleoporin FG repeat region Spc7 PF08317.11 AET37984.1 - 2.4e-76 256.6 11.7 4.7e-76 255.6 11.7 1.5 1 0 0 1 1 1 1 Spc7 kinetochore protein Spc7_C2 PF15577.6 AET37984.1 - 0.036 14.2 0.8 0.48 10.5 0.1 2.7 2 0 0 2 2 2 0 Spc7_C2 BLOC1_2 PF10046.9 AET37984.1 - 0.1 12.9 0.2 0.1 12.9 0.2 3.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1319 PF07028.11 AET37984.1 - 0.84 9.9 8.3 0.71 10.1 2.6 3.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1319) THOC7 PF05615.13 AET37984.1 - 4.1 7.7 14.0 0.57 10.5 1.7 3.7 4 0 0 4 4 4 0 Tho complex subunit 7 DUF1664 PF07889.12 AET37984.1 - 8.6 6.4 8.6 2.2 8.3 1.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Ribosomal_L36 PF00444.18 AET37985.1 - 1.9e-20 72.7 11.3 2.9e-20 72.2 11.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L36 Crust_neurohorm PF01147.17 AET37985.1 - 0.01 15.6 1.6 0.016 15.0 1.6 1.3 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family WD40 PF00400.32 AET37986.1 - 1.1e-20 73.5 17.3 3.3e-07 30.9 0.0 10.1 10 0 0 10 10 10 3 WD domain, G-beta repeat Nup160 PF11715.8 AET37986.1 - 0.00036 19.3 8.0 0.081 11.6 0.1 4.1 5 0 0 5 5 5 3 Nucleoporin Nup120/160 Str_synth PF03088.16 AET37986.1 - 0.032 14.3 0.0 0.36 11.0 0.0 2.8 3 0 0 3 3 3 0 Strictosidine synthase DUF4989 PF16379.5 AET37986.1 - 0.033 13.5 0.0 0.25 10.6 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4989) YmzC PF14157.6 AET37986.1 - 0.041 14.0 0.0 4.6 7.4 0.0 3.0 2 0 0 2 2 2 0 YmzC-like protein UCH_1 PF13423.6 AET37987.1 - 2.8e-74 250.6 2.2 3.9e-74 250.1 2.2 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 AET37987.1 - 7.4e-24 85.2 0.0 2.8e-23 83.3 0.0 2.1 2 0 0 2 2 2 1 Exonuclease UCH PF00443.29 AET37987.1 - 4.5e-06 26.3 0.8 7.3e-05 22.4 0.8 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ANAPC4_WD40 PF12894.7 AET37987.1 - 0.035 14.4 0.0 3.1 8.2 0.0 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Acetyltransf_11 PF13720.6 AET37987.1 - 0.05 14.1 0.0 3.3 8.2 0.0 2.9 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 TCO89 PF10452.9 AET37988.1 - 3.2e-115 386.4 39.2 5.1e-113 379.1 39.2 2.1 1 1 0 1 1 1 1 TORC1 subunit TCO89 FNIP_C PF14638.6 AET37988.1 - 0.028 14.0 0.1 0.05 13.2 0.1 1.4 1 0 0 1 1 1 0 Folliculin-interacting protein C-terminus Sec1 PF00995.23 AET37989.1 - 1.2e-114 384.7 14.3 1.4e-114 384.5 14.3 1.0 1 0 0 1 1 1 1 Sec1 family L27 PF02828.16 AET37989.1 - 0.0059 16.3 0.1 0.018 14.8 0.1 1.9 1 0 0 1 1 1 1 L27 domain DUF4201 PF13870.6 AET37989.1 - 1.3 8.7 8.6 0.39 10.4 4.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) SIX1_SD PF16878.5 AET37989.1 - 1.8 9.1 5.2 1.3 9.6 1.5 2.6 2 1 0 2 2 2 0 Transcriptional regulator, SIX1, N-terminal SD domain DUF1836 PF08876.11 AET37989.1 - 8.5 6.5 11.3 1.5 8.9 0.3 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF1836) PHD PF00628.29 AET37990.1 - 6.4e-10 38.8 6.4 1.2e-09 37.9 6.4 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 AET37990.1 - 0.41 10.2 6.1 0.74 9.4 6.1 1.5 1 0 0 1 1 1 0 PHD-finger Metallophos PF00149.28 AET37991.1 - 3.8e-36 125.5 0.1 7e-36 124.7 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 AET37991.1 - 5.1e-16 58.9 0.0 1e-15 57.8 0.0 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain RRM_1 PF00076.22 AET37992.1 - 1.1e-14 54.0 0.0 1.7e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SelP_N PF04592.14 AET37992.1 - 0.34 10.3 20.1 0.5 9.7 20.1 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PDGF_N PF04692.13 AET37992.1 - 2.1 9.2 8.5 4 8.3 8.5 1.4 1 0 0 1 1 1 0 Platelet-derived growth factor, N terminal region Homeobox_KN PF05920.11 AET37993.1 - 6.6e-19 67.5 0.8 1.6e-18 66.3 0.8 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 AET37993.1 - 2.5e-06 27.2 0.3 6.2e-06 26.0 0.3 1.7 1 0 0 1 1 1 1 Homeodomain Arrestin_N PF00339.29 AET37994.1 - 0.014 15.4 0.1 0.034 14.2 0.0 1.7 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain DAHP_synth_1 PF00793.20 AET37995.1 - 1.7e-104 348.5 0.0 2.1e-104 348.3 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family His_biosynth PF00977.21 AET37996.1 - 1.2e-46 159.1 0.4 4.5e-46 157.2 0.4 2.0 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 AET37996.1 - 2e-20 73.4 0.0 3.2e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 AET37996.1 - 1e-07 31.8 0.0 2.1e-07 30.8 0.0 1.5 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 AET37996.1 - 3.6e-07 30.2 0.0 7.9e-05 22.6 0.0 2.2 2 0 0 2 2 2 2 SNO glutamine amidotransferase family UPRTase PF14681.6 AET37996.1 - 0.0085 15.6 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DJ-1_PfpI PF01965.24 AET37996.1 - 0.025 14.4 0.0 0.067 13.0 0.0 1.7 1 0 0 1 1 1 0 DJ-1/PfpI family Dus PF01207.17 AET37996.1 - 0.026 13.6 0.0 0.059 12.4 0.0 1.5 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) NMO PF03060.15 AET37996.1 - 0.11 11.8 0.4 1.5 8.1 0.0 2.2 2 0 0 2 2 2 0 Nitronate monooxygenase ThiG PF05690.14 AET37996.1 - 0.18 11.1 0.0 0.32 10.3 0.0 1.4 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG RCC1 PF00415.18 AET37997.1 - 8.5e-64 212.0 1.0 6.7e-13 49.1 0.0 7.4 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 AET37997.1 - 4.9e-42 140.9 20.9 1.8e-09 37.1 0.1 6.7 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat SUKH-3 PF14433.6 AET37997.1 - 0.055 13.9 2.1 7 7.1 0.0 3.7 5 0 0 5 5 5 0 SUKH-3 immunity protein Bystin PF05291.11 AET37998.1 - 1.1e-123 412.2 0.0 1.4e-123 411.9 0.0 1.1 1 0 0 1 1 1 1 Bystin Use1 PF09753.9 AET37999.1 - 5.7e-10 39.3 3.3 1.1e-09 38.5 3.3 1.5 1 1 0 1 1 1 1 Membrane fusion protein Use1 MethyTransf_Reg PF10119.9 AET37999.1 - 0.025 15.3 0.2 2.7 8.8 0.2 3.2 3 1 0 3 3 3 0 Predicted methyltransferase regulatory domain Ald_Xan_dh_C PF01315.22 AET37999.1 - 0.058 13.7 0.0 7.8 6.9 0.0 2.3 2 0 0 2 2 2 0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain DUF2939 PF11159.8 AET37999.1 - 0.086 13.3 3.3 0.13 12.6 0.5 2.6 2 2 1 3 3 3 0 Protein of unknown function (DUF2939) Rho_GDI PF02115.17 AET37999.1 - 1.5 8.5 7.4 0.82 9.4 4.2 1.9 1 1 1 2 2 2 0 RHO protein GDP dissociation inhibitor MMR_HSR1 PF01926.23 AET38000.1 - 1.3e-16 60.7 0.1 6.3e-15 55.3 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AET38000.1 - 1.5e-08 34.3 0.1 3.6e-06 26.6 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AET38000.1 - 9.1e-06 25.7 0.2 0.013 15.4 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 AET38000.1 - 0.0036 16.7 0.1 0.009 15.4 0.1 1.6 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 AET38000.1 - 0.81 9.7 10.0 0.069 13.2 0.7 3.2 3 1 0 3 3 3 0 Dynamin family WD40 PF00400.32 AET38001.1 - 5.8e-05 23.8 2.9 4.2 8.4 0.2 5.9 6 0 0 6 6 6 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET38001.1 - 0.00033 20.9 0.0 0.0035 17.6 0.0 2.5 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 AET38001.1 - 0.00046 20.0 1.2 2.4 8.2 0.0 3.6 4 0 0 4 4 4 2 PQQ enzyme repeat AraC_N PF06719.13 AET38001.1 - 0.19 11.4 0.0 0.33 10.6 0.0 1.3 1 0 0 1 1 1 0 AraC-type transcriptional regulator N-terminus SNF2_N PF00176.23 AET38002.1 - 2.4e-73 246.9 0.1 4.5e-73 246.0 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 AET38002.1 - 2.9e-38 130.4 1.8 2.9e-38 130.4 1.8 3.1 3 0 0 3 3 3 1 SLIDE HAND PF09110.11 AET38002.1 - 1.3e-28 99.9 0.6 1.3e-28 99.9 0.6 4.8 5 1 0 5 5 3 1 HAND Helicase_C PF00271.31 AET38002.1 - 1.1e-19 70.8 0.0 3e-19 69.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET38002.1 - 3.1e-12 46.8 0.0 2.4e-11 44.0 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 AET38002.1 - 1.1e-09 37.9 0.0 3.2e-09 36.4 0.0 1.8 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 AET38002.1 - 5.5e-06 26.3 0.0 1.5e-05 24.8 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Myb_DNA-binding PF00249.31 AET38002.1 - 0.00038 20.6 0.1 0.52 10.5 0.0 3.7 3 0 0 3 3 3 1 Myb-like DNA-binding domain ERCC3_RAD25_C PF16203.5 AET38002.1 - 0.0014 17.9 0.1 0.0014 17.9 0.1 1.9 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 AET38002.1 - 0.0043 16.7 0.0 0.012 15.3 0.0 1.8 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DEAD_2 PF06733.15 AET38002.1 - 0.015 14.9 0.1 0.036 13.7 0.1 1.6 1 0 0 1 1 1 0 DEAD_2 AAA_14 PF13173.6 AET38002.1 - 0.04 14.0 0.7 0.29 11.2 0.1 2.7 2 0 0 2 2 2 0 AAA domain GSHPx PF00255.19 AET38003.1 - 4e-47 158.3 0.5 5.3e-47 157.9 0.5 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 AET38003.1 - 1.6e-07 31.3 0.1 6.2e-07 29.4 0.1 1.8 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AET38003.1 - 2.3e-05 24.1 0.0 7.4e-05 22.5 0.0 1.8 1 1 0 1 1 1 1 Redoxin WD40 PF00400.32 AET38004.1 - 1.5e-20 73.1 18.3 8.6e-05 23.2 1.0 5.6 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET38004.1 - 3.9e-09 36.7 0.2 0.034 14.4 0.1 3.9 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain YmzC PF14157.6 AET38004.1 - 0.015 15.4 0.0 0.68 10.1 0.0 2.6 2 0 0 2 2 2 0 YmzC-like protein Rav1p_C PF12234.8 AET38004.1 - 0.1 11.0 0.0 0.15 10.4 0.0 1.2 1 0 0 1 1 1 0 RAVE protein 1 C terminal Glycos_transf_4 PF00953.21 AET38005.1 - 4.7e-34 117.7 10.1 4.7e-34 117.7 10.1 2.3 2 1 0 2 2 2 1 Glycosyl transferase family 4 HD_3 PF13023.6 AET38006.1 - 8.4e-35 120.1 0.1 1.1e-34 119.8 0.1 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 AET38006.1 - 5.6e-10 39.3 0.1 7.7e-10 38.8 0.1 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 AET38006.1 - 8.5e-06 26.0 0.1 0.00012 22.3 0.1 2.2 1 1 0 1 1 1 1 HD domain Ribosomal_L27A PF00828.19 AET38007.1 - 1.4e-22 80.7 0.1 2.4e-22 80.0 0.0 1.4 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Sugar_tr PF00083.24 AET38008.1 - 2.7e-99 333.1 19.7 3.3e-99 332.8 19.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AET38008.1 - 2.3e-27 95.9 58.9 3.7e-26 91.9 31.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 AET38008.1 - 1.1e-07 31.5 10.5 3.5e-07 29.9 6.7 2.5 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 AET38008.1 - 4.3e-07 28.7 1.7 4.3e-07 28.7 1.7 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MCM_bind PF09739.9 AET38008.1 - 0.23 9.9 0.0 0.32 9.4 0.0 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Zn_clus PF00172.18 AET38009.1 - 9.2e-11 41.7 6.1 9.2e-11 41.7 6.1 2.4 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain S_100 PF01023.19 AET38009.1 - 0.11 12.2 0.1 0.31 10.8 0.1 1.8 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain tRNA_bind PF01588.20 AET38010.1 - 3.7e-28 97.5 0.4 1e-27 96.1 0.1 1.9 2 0 0 2 2 2 1 Putative tRNA binding domain Peptidase_U32_C PF16325.5 AET38010.1 - 0.019 15.2 0.3 0.064 13.5 0.1 2.0 2 0 0 2 2 2 0 Peptidase family U32 C-terminal domain PAS PF00989.25 AET38011.1 - 3.1e-15 56.2 0.0 1.3e-14 54.2 0.0 2.0 2 0 0 2 2 2 1 PAS fold Zn_clus PF00172.18 AET38011.1 - 1.2e-06 28.5 10.9 2.3e-06 27.6 10.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EF-hand_7 PF13499.6 AET38012.1 - 1.6e-10 41.3 0.7 2.4e-07 31.1 0.6 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AET38012.1 - 5.3e-10 38.4 1.4 0.00014 21.5 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_9 PF14658.6 AET38012.1 - 1.5e-08 34.9 0.0 0.0013 19.0 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 AET38012.1 - 2.6e-06 26.6 5.2 0.00083 18.7 0.1 3.0 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 AET38012.1 - 8.2e-06 25.6 0.7 3.8e-05 23.4 0.3 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_14 PF17959.1 AET38012.1 - 0.0068 16.7 0.0 0.48 10.8 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_11 PF08976.11 AET38012.1 - 0.015 16.1 0.0 0.024 15.5 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain TPR_19 PF14559.6 AET38013.1 - 0.11 13.1 0.2 0.32 11.5 0.1 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat DEAD PF00270.29 AET38015.1 - 4e-44 150.5 0.0 8e-44 149.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET38015.1 - 5.1e-21 75.1 0.0 2.2e-20 73.0 0.0 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET38015.1 - 1.3e-06 28.5 0.1 1e-05 25.6 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 AET38015.1 - 0.019 15.2 0.0 0.072 13.4 0.0 2.0 1 1 0 1 1 1 0 AAA domain TTRAP PF14203.6 AET38015.1 - 0.041 13.9 1.9 0.087 12.8 0.1 2.4 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein Fis1_TPR_N PF14852.6 AET38015.1 - 0.38 10.5 1.8 3.4 7.4 0.1 2.7 3 0 0 3 3 3 0 Fis1 N-terminal tetratricopeptide repeat Pox_MCEL PF03291.16 AET38016.1 - 2.4e-100 335.9 0.3 3.2e-100 335.5 0.3 1.1 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 AET38016.1 - 5.7e-11 43.0 0.0 1.3e-10 41.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AET38016.1 - 5.2e-08 32.9 0.1 1.2e-07 31.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 AET38016.1 - 6.5e-08 33.2 0.3 2.4e-07 31.4 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AET38016.1 - 2.1e-07 31.5 0.1 7e-07 29.8 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AET38016.1 - 2.3e-06 27.5 0.1 7.1e-06 25.9 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 AET38016.1 - 0.0016 17.7 0.0 0.0045 16.2 0.0 1.7 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family CMAS PF02353.20 AET38016.1 - 0.0064 15.8 1.3 0.023 14.0 0.0 2.2 2 1 0 3 3 3 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 AET38016.1 - 0.022 14.5 0.1 0.048 13.4 0.1 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CagY_I PF14585.6 AET38016.1 - 0.068 13.3 0.6 0.26 11.4 0.6 1.9 2 0 0 2 2 2 0 CagY type 1 repeat Ret2_MD PF18528.1 AET38016.1 - 0.11 12.8 0.8 0.31 11.5 0.8 1.7 1 0 0 1 1 1 0 RNA editing 3' terminal uridylyl transferase 2 middle domain AA_permease PF00324.21 AET38017.1 - 1.4e-45 155.8 40.2 1.4e-45 155.8 40.2 1.5 2 0 0 2 2 2 1 Amino acid permease SLC12 PF03522.15 AET38017.1 - 1.9e-17 63.4 2.4 3.2e-08 33.1 0.0 3.1 3 0 0 3 3 3 3 Solute carrier family 12 CUE PF02845.16 AET38018.1 - 1e-08 34.7 0.1 2.9e-08 33.3 0.1 1.8 1 0 0 1 1 1 1 CUE domain PRP1_N PF06424.12 AET38019.1 - 0.083 13.3 2.1 0.18 12.2 2.1 1.5 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal WD40 PF00400.32 AET38020.1 - 2.4e-10 40.8 9.0 0.0023 18.7 0.1 5.8 5 2 2 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET38020.1 - 3.7e-10 39.9 2.3 0.0059 16.9 0.0 4.3 2 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AET38020.1 - 0.00067 19.6 0.5 0.078 12.8 0.2 2.8 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Hira PF07569.11 AET38020.1 - 0.083 12.6 0.1 0.16 11.7 0.1 1.4 1 0 0 1 1 1 0 TUP1-like enhancer of split DASH_Dad3 PF08656.10 AET38021.1 - 1.5e-24 85.8 1.3 1.6e-24 85.7 1.3 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad3 FlxA PF14282.6 AET38021.1 - 0.089 12.8 0.1 0.11 12.5 0.1 1.1 1 0 0 1 1 1 0 FlxA-like protein bPH_6 PF10756.9 AET38021.1 - 0.15 12.2 0.1 0.2 11.8 0.1 1.2 1 0 0 1 1 1 0 Bacterial PH domain TAF6_C PF07571.13 AET38022.1 - 3.2e-30 104.3 0.0 7.8e-30 103.1 0.0 1.7 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 AET38022.1 - 3.5e-28 97.6 0.3 7.4e-28 96.5 0.3 1.6 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 AET38022.1 - 0.0013 19.1 2.1 0.063 13.6 0.2 2.4 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 AET38022.1 - 0.0014 18.7 0.0 0.004 17.2 0.0 1.7 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit DUF348 PF03990.14 AET38022.1 - 0.02 14.6 0.0 0.057 13.2 0.0 1.7 1 0 0 1 1 1 0 G5-linked-Ubiquitin-like domain CAF1 PF04857.20 AET38022.1 - 0.024 13.8 0.2 0.033 13.4 0.2 1.3 1 0 0 1 1 1 0 CAF1 family ribonuclease CLASP_N PF12348.8 AET38022.1 - 0.036 13.6 2.8 0.12 11.9 0.5 2.4 2 1 0 3 3 3 0 CLASP N terminal Sec7_N PF12783.7 AET38022.1 - 0.05 13.5 6.2 6.2 6.7 0.1 3.4 1 1 1 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal TAF4 PF05236.14 AET38022.1 - 0.053 13.3 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family CBFD_NFYB_HMF PF00808.23 AET38022.1 - 0.16 12.2 0.5 0.56 10.5 0.1 2.2 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Pyr_redox_3 PF13738.6 AET38022.1 - 0.22 10.7 0.7 0.36 10.0 0.2 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase CENP-S PF15630.6 AET38022.1 - 0.32 11.4 4.8 2.8 8.4 0.1 3.3 4 0 0 4 4 4 0 CENP-S protein SLD3 PF08639.10 AET38023.1 - 3e-40 138.5 27.0 1.8e-29 103.0 24.0 3.3 2 1 0 2 2 2 2 DNA replication regulator SLD3 Sld3_N PF18523.1 AET38023.1 - 1.8e-31 108.7 0.2 4.3e-31 107.4 0.2 1.7 1 0 0 1 1 1 1 Sld3 N-terminal domain KH_1 PF00013.29 AET38024.1 - 1.5e-35 120.8 10.7 1.1e-11 44.3 3.6 4.0 4 0 0 4 4 4 3 KH domain KH_2 PF07650.17 AET38024.1 - 6.2e-11 42.0 1.5 0.049 13.5 0.0 3.6 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 AET38024.1 - 0.00019 21.3 0.4 0.96 9.4 0.0 3.0 2 1 0 2 2 2 2 KH domain KH_5 PF13184.6 AET38024.1 - 0.049 13.7 4.0 25 5.1 0.2 3.7 3 0 0 3 3 3 0 NusA-like KH domain BCNT PF07572.12 AET38025.1 - 1e-23 83.2 1.9 3.8e-23 81.3 0.1 2.3 2 0 0 2 2 2 1 Bucentaur or craniofacial development Carbpep_Y_N PF05388.11 AET38025.1 - 2.1 8.9 4.7 0.86 10.2 0.2 2.6 3 1 1 4 4 4 0 Carboxypeptidase Y pro-peptide CBS PF00571.28 AET38026.1 - 2.1e-24 85.7 3.3 2.1e-10 40.9 0.1 4.2 4 0 0 4 4 4 4 CBS domain dCache_1 PF02743.18 AET38026.1 - 0.08 12.7 0.1 0.21 11.4 0.1 1.7 1 1 0 1 1 1 0 Cache domain WD40 PF00400.32 AET38027.1 - 1.9e-13 50.6 14.7 6.2e-05 23.7 0.2 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET38027.1 - 6.1e-12 45.7 8.6 0.015 15.5 0.3 4.9 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AET38027.1 - 2.4e-07 30.0 0.1 3.8e-05 22.8 0.0 2.9 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 AET38027.1 - 3e-05 24.0 1.5 0.015 15.2 0.2 2.8 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 AET38027.1 - 0.04 13.2 0.4 21 4.3 0.0 3.0 2 1 0 2 2 2 0 WD40-like domain CheD PF03975.13 AET38028.1 - 0.095 12.8 0.0 0.92 9.6 0.0 2.2 1 1 1 2 2 2 0 CheD chemotactic sensory transduction GAF_2 PF13185.6 AET38029.1 - 1.1e-10 41.9 0.0 1.6e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 AET38029.1 - 0.00012 22.7 0.0 0.00016 22.3 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 AET38029.1 - 0.056 13.8 0.0 0.081 13.3 0.0 1.5 1 1 0 1 1 1 0 GAF domain BOP1NT PF08145.12 AET38030.1 - 1.8e-103 346.0 6.5 2.9e-103 345.3 6.5 1.3 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 AET38030.1 - 1.1e-25 89.4 4.5 2.1e-10 41.0 0.2 5.9 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET38030.1 - 4.7e-08 33.2 0.4 0.0027 18.0 0.0 4.9 5 1 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Swi3 PF07962.12 AET38031.1 - 7.5e-27 93.1 0.6 1.3e-26 92.3 0.6 1.4 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 Takusan PF04822.13 AET38031.1 - 0.11 12.4 0.2 0.21 11.5 0.2 1.5 1 0 0 1 1 1 0 Takusan Nucleoporin_FG PF13634.6 AET38033.1 - 4.1e-43 146.2 376.8 1.3e-13 51.6 34.4 13.3 3 2 10 13 13 13 11 Nucleoporin FG repeat region Nucleoporin2 PF04096.14 AET38033.1 - 3e-36 124.8 0.0 5.3e-36 124.0 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin autopeptidase SRF-TF PF00319.18 AET38034.1 - 7.9e-21 73.3 0.1 1.2e-20 72.7 0.1 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) TFIIE-A_C PF11521.8 AET38034.1 - 0.046 14.0 2.6 0.046 14.0 2.6 2.4 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha DNA_pol_phi PF04931.13 AET38034.1 - 1.2 7.2 3.3 1.6 6.7 3.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi PWWP PF00855.17 AET38035.1 - 2.7e-21 75.8 0.4 2.7e-21 75.8 0.4 2.3 3 0 0 3 3 3 1 PWWP domain NDK PF00334.19 AET38036.1 - 8.8e-55 184.4 0.0 1e-54 184.2 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Bap31 PF05529.12 AET38037.1 - 3.2e-26 91.8 2.4 4.6e-26 91.3 2.4 1.2 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region SSF PF00474.17 AET38037.1 - 0.061 12.2 0.2 0.061 12.2 0.2 1.2 1 0 0 1 1 1 0 Sodium:solute symporter family APG6_N PF17675.1 AET38037.1 - 0.1 13.2 6.4 0.16 12.5 6.4 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region Xan_ur_permease PF00860.20 AET38037.1 - 0.15 10.8 0.1 0.15 10.8 0.1 1.5 2 0 0 2 2 2 0 Permease family DivIC PF04977.15 AET38037.1 - 0.45 10.3 4.9 0.48 10.2 3.0 2.0 1 1 1 2 2 2 0 Septum formation initiator LapA_dom PF06305.11 AET38037.1 - 5.6 6.9 6.0 7.1 6.5 0.9 3.3 2 1 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Aldo_ket_red PF00248.21 AET38038.1 - 3.4e-51 174.2 0.0 4.3e-51 173.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PC4 PF02229.16 AET38039.1 - 1.6e-23 82.1 0.1 3.2e-23 81.1 0.1 1.6 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) CorA PF01544.18 AET38040.1 - 1.7e-38 132.6 2.7 3.3e-22 79.2 0.5 3.4 3 0 0 3 3 3 3 CorA-like Mg2+ transporter protein HMA PF00403.26 AET38041.1 - 7.7e-14 51.9 0.2 1.4e-13 51.1 0.2 1.4 1 0 0 1 1 1 1 Heavy-metal-associated domain Sod_Cu PF00080.20 AET38041.1 - 6.9e-06 26.3 0.3 3.7e-05 23.9 0.3 2.0 1 1 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) GHMP_kinases_C PF08544.13 AET38042.1 - 8.1 6.9 13.9 0.21 12.0 0.8 2.3 1 1 1 2 2 2 0 GHMP kinases C terminal zf-C2H2 PF00096.26 AET38043.1 - 6.2e-13 48.4 13.2 4.2e-06 26.9 3.3 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AET38043.1 - 3.8e-09 36.6 12.3 0.00013 22.5 1.7 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AET38043.1 - 1.2e-06 28.6 8.9 0.0015 18.8 2.2 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 AET38043.1 - 1.4e-06 28.4 19.5 1.9e-05 24.9 3.3 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-BED PF02892.15 AET38043.1 - 5.4e-05 23.1 5.4 0.057 13.4 1.0 2.9 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_6 PF13912.6 AET38043.1 - 0.00014 21.7 12.1 0.00047 20.1 3.3 2.8 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2HE PF16278.5 AET38043.1 - 0.004 17.6 8.6 0.5 10.9 1.0 2.7 1 1 1 2 2 2 2 C2HE / C2H2 / C2HC zinc-binding finger zf-AN1 PF01428.16 AET38043.1 - 0.14 12.4 7.5 23 5.3 0.3 3.5 3 0 0 3 3 3 0 AN1-like Zinc finger zf-C2H2_2 PF12756.7 AET38043.1 - 0.33 11.3 6.3 1 9.7 0.7 2.5 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF4518 PF15008.6 AET38043.1 - 0.68 9.1 3.5 0.39 9.9 1.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) zf-C2H2_11 PF16622.5 AET38043.1 - 0.93 9.3 4.5 3.1 7.6 0.3 2.6 2 0 0 2 2 2 0 zinc-finger C2H2-type FidL_like PF15941.5 AET38043.1 - 1.3 9.5 4.7 4.8 7.7 0.1 3.0 3 0 0 3 3 3 0 FidL-like putative membrane protein zf-H2C2_5 PF13909.6 AET38043.1 - 1.8 8.4 20.2 0.18 11.6 3.2 3.5 2 1 0 2 2 2 0 C2H2-type zinc-finger domain Pkinase PF00069.25 AET38044.1 - 1e-32 113.5 0.1 2.7e-18 66.3 0.0 3.1 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 AET38044.1 - 1.5e-19 70.3 0.0 4.2e-12 45.9 0.0 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase Kinase-like PF14531.6 AET38044.1 - 0.00013 21.3 0.1 0.073 12.4 0.0 3.0 3 1 0 3 3 3 2 Kinase-like APH PF01636.23 AET38044.1 - 0.015 15.2 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 AET38044.1 - 0.036 13.7 0.0 0.47 10.0 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Rhodanese PF00581.20 AET38045.1 - 1e-09 38.9 0.0 2.3e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain Peptidase_S24 PF00717.23 AET38046.1 - 6.4e-09 35.6 0.2 1.8e-08 34.2 0.2 1.7 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 AET38046.1 - 7.4e-05 22.6 0.0 0.0015 18.4 0.0 2.1 1 1 1 2 2 2 1 Signal peptidase, peptidase S26 SBF_like PF13593.6 AET38047.1 - 2.9e-108 361.9 19.9 3.4e-108 361.7 19.9 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.16 AET38047.1 - 2.7e-13 50.1 10.5 2.7e-13 50.1 10.5 2.0 1 1 1 2 2 2 1 Sodium Bile acid symporter family Actin PF00022.19 AET38048.1 - 5.7e-22 77.9 0.0 5.9e-20 71.3 0.0 2.7 2 1 0 2 2 2 1 Actin MreB_Mbl PF06723.13 AET38048.1 - 0.012 14.4 0.0 5.5 5.7 0.0 3.0 3 0 0 3 3 3 0 MreB/Mbl protein FtsA PF14450.6 AET38048.1 - 0.072 13.5 0.2 0.17 12.3 0.2 1.6 1 1 0 1 1 1 0 Cell division protein FtsA Actin_micro PF17003.5 AET38048.1 - 0.09 11.9 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Putative actin-like family Histone PF00125.24 AET38049.1 - 2.3e-38 131.5 7.5 2.3e-38 131.5 7.5 2.0 1 1 1 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 AET38049.1 - 0.0044 17.1 1.3 0.0059 16.7 0.1 1.8 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 AET38049.1 - 0.0092 16.3 0.1 0.02 15.2 0.1 1.5 1 0 0 1 1 1 1 CENP-S protein DUF2459 PF09601.10 AET38049.1 - 0.19 11.5 1.4 0.2 11.5 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2459) Atg14 PF10186.9 AET38049.1 - 3.6 6.6 11.8 4.9 6.2 11.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FCH PF00611.23 AET38050.1 - 4.3e-11 43.0 0.3 4.3e-11 43.0 0.3 2.5 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.6 AET38050.1 - 2.2e-08 33.8 0.0 4.1e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AET38050.1 - 1.5e-07 31.0 0.0 3e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 AET38050.1 - 1.8e-07 30.6 0.0 4.1e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 SH3 domain PFK PF00365.20 AET38050.1 - 0.061 12.6 0.0 0.14 11.4 0.0 1.6 1 0 0 1 1 1 0 Phosphofructokinase GH97_C PF14509.6 AET38050.1 - 0.1 12.8 0.1 0.56 10.5 0.0 2.2 2 0 0 2 2 2 0 Glycosyl-hydrolase 97 C-terminal, oligomerisation CBP4 PF07960.11 AET38050.1 - 0.48 10.3 0.0 0.48 10.3 0.0 4.1 3 1 1 4 4 4 0 CBP4 LLC1 PF14945.6 AET38050.1 - 0.52 10.9 3.3 0.49 11.0 0.5 2.4 1 1 1 2 2 2 0 Normal lung function maintenance, Low in Lung Cancer 1 protein Eisosome1 PF12757.7 AET38051.1 - 3.2e-28 98.5 5.1 3.2e-28 98.5 5.1 3.7 2 0 0 2 2 2 1 Eisosome protein 1 Frag1 PF10277.9 AET38052.1 - 8.6e-73 244.5 23.9 1e-72 244.3 23.9 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Actin PF00022.19 AET38053.1 - 5.3e-22 78.0 0.0 1.5e-15 56.7 0.0 3.6 3 1 0 3 3 3 3 Actin Actin_micro PF17003.5 AET38053.1 - 3.3e-12 46.3 1.4 4.5e-05 22.8 0.1 2.4 2 0 0 2 2 2 2 Putative actin-like family MreB_Mbl PF06723.13 AET38053.1 - 2.6e-06 26.5 0.1 6.2e-05 22.0 0.0 2.5 2 1 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 AET38053.1 - 0.001 19.4 0.3 0.0045 17.4 0.3 2.3 1 1 0 1 1 1 1 Cell division protein FtsA HSF_DNA-bind PF00447.17 AET38054.1 - 5.7e-30 103.8 2.1 5.7e-30 103.8 2.1 2.1 2 0 0 2 2 2 1 HSF-type DNA-binding Iso_dh PF00180.20 AET38055.1 - 1.2e-104 350.3 0.0 1.3e-104 350.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase ThiF PF00899.21 AET38056.1 - 3.7e-66 223.0 0.0 5.2e-66 222.5 0.0 1.1 1 0 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.9 AET38056.1 - 1.6e-08 34.8 4.0 3.7e-05 23.8 1.7 2.5 1 1 0 2 2 2 2 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.20 AET38056.1 - 0.013 15.6 0.1 0.027 14.5 0.1 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 AET38056.1 - 0.029 14.8 0.0 0.081 13.4 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding RhoGAP PF00620.27 AET38057.1 - 1.6e-31 109.1 0.1 2.4e-18 66.4 0.0 2.6 2 0 0 2 2 2 2 RhoGAP domain BAR PF03114.18 AET38058.1 - 5.9e-60 202.9 8.1 8.3e-60 202.4 8.1 1.2 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 AET38058.1 - 1.8e-12 46.7 0.0 3e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AET38058.1 - 3e-11 43.0 0.0 5.6e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AET38058.1 - 3.3e-06 26.7 0.0 6.9e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain IFP_35_N PF07334.13 AET38058.1 - 0.85 9.7 2.7 3 8.0 0.3 2.4 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Sugar_tr PF00083.24 AET38059.1 - 3.2e-79 266.9 27.3 1.3e-45 156.1 5.6 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 AET38059.1 - 1e-22 80.6 19.8 1e-22 80.6 19.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily ERCC4 PF02732.15 AET38060.1 - 1e-22 81.0 0.2 2.3e-22 79.9 0.2 1.6 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.6 AET38060.1 - 0.00027 21.3 0.1 0.0018 18.6 0.0 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix domain HTH_45 PF14947.6 AET38060.1 - 0.055 13.5 0.0 0.17 11.9 0.0 1.9 1 0 0 1 1 1 0 Winged helix-turn-helix GTP_EFTU PF00009.27 AET38061.1 - 4.2e-68 228.7 0.1 6.1e-68 228.2 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 AET38061.1 - 1.7e-31 108.5 0.0 6.7e-31 106.6 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 AET38061.1 - 4e-22 78.1 0.0 1.5e-21 76.2 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G C-terminus EFG_II PF14492.6 AET38061.1 - 2.2e-13 50.1 0.0 7.4e-13 48.4 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 AET38061.1 - 8.9e-13 48.4 0.0 2.6e-12 46.9 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AET38061.1 - 0.0001 22.4 0.3 0.0002 21.4 0.3 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase PX PF00787.24 AET38062.1 - 3.3e-11 43.2 0.0 1.4e-10 41.2 0.0 2.1 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 AET38062.1 - 0.00024 20.7 12.6 0.00044 19.9 12.6 1.3 1 0 0 1 1 1 1 Vps5 C terminal like Arfaptin PF06456.13 AET38062.1 - 0.00038 20.1 0.9 0.013 15.0 0.0 2.5 2 0 0 2 2 2 1 Arfaptin-like domain Flexi_CP_N PF08358.10 AET38062.1 - 0.003 17.5 0.0 0.31 11.0 0.0 3.2 3 1 0 3 3 3 1 Carlavirus coat Seryl_tRNA_N PF02403.22 AET38062.1 - 0.19 11.9 5.2 1.3 9.3 2.2 3.2 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Gpr1_Fun34_YaaH PF01184.19 AET38063.1 - 3e-70 236.0 21.2 3.8e-70 235.7 21.2 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family WHIM1 PF15612.6 AET38064.1 - 8.3e-07 28.4 0.0 2.6e-06 26.8 0.0 2.0 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 TcdB_N PF12918.7 AET38064.1 - 0.067 13.5 1.8 0.21 11.9 1.8 1.9 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain PI-PLC-X PF00388.19 AET38065.1 - 4.4e-18 65.3 0.0 1.6e-17 63.4 0.0 1.8 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain WD40 PF00400.32 AET38066.1 - 0.0011 19.7 0.5 1.7 9.6 0.1 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat BPL_LplA_LipB PF03099.19 AET38067.1 - 2e-07 30.9 0.1 5.1e-07 29.7 0.1 1.6 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family DUF4815 PF16075.5 AET38067.1 - 0.09 11.1 0.0 0.13 10.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4815) MapZ_EC1 PF18041.1 AET38067.1 - 0.098 12.9 0.2 0.49 10.6 0.1 2.1 2 0 0 2 2 2 0 MapZ extracellular domain 1 UPF0086 PF01868.16 AET38068.1 - 2.3e-22 78.7 0.0 5.1e-22 77.6 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function UPF0086 COMPASS-Shg1 PF05205.12 AET38069.1 - 3.7e-20 72.5 1.5 4.5e-20 72.2 1.5 1.1 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 SecY PF00344.20 AET38071.1 - 6.8e-38 130.6 19.3 1e-37 130.0 19.3 1.2 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 AET38071.1 - 2.1e-09 37.0 0.1 8.2e-09 35.2 0.1 2.1 1 0 0 1 1 1 1 Plug domain of Sec61p AIM5 PF17050.5 AET38072.1 - 1.2e-07 32.4 0.1 1.6e-07 32.0 0.1 1.2 1 0 0 1 1 1 1 Altered inheritance of mitochondria 5 Methyltransf_PK PF05891.12 AET38073.1 - 9.4e-88 293.4 0.0 1.1e-87 293.2 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 AET38073.1 - 2.7e-07 31.2 0.0 4.9e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AET38073.1 - 0.0018 18.9 0.0 0.0032 18.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AET38073.1 - 0.0062 16.4 0.0 0.013 15.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Bin3 PF06859.12 AET38073.1 - 0.054 14.1 0.0 0.093 13.4 0.0 1.3 1 0 0 1 1 1 0 Bicoid-interacting protein 3 (Bin3) RhoGAP PF00620.27 AET38074.1 - 3e-40 137.5 0.2 3e-39 134.3 0.0 2.3 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 AET38074.1 - 4.7e-06 26.8 2.3 2.7e-05 24.4 2.3 2.3 1 1 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Sec34 PF04136.15 AET38074.1 - 0.029 14.3 3.1 0.15 12.0 1.3 2.8 4 0 0 4 4 4 0 Sec34-like family FliJ PF02050.16 AET38074.1 - 0.59 10.4 4.6 1.1 9.5 3.9 1.9 1 1 0 1 1 1 0 Flagellar FliJ protein MSV199 PF10553.9 AET38074.1 - 1.3 9.3 5.5 3 8.1 0.4 2.5 2 0 0 2 2 2 0 MSV199 domain Cullin_Nedd8 PF10557.9 AET38075.1 - 0.097 12.7 0.8 1.6 8.8 0.0 3.4 4 0 0 4 4 4 0 Cullin protein neddylation domain EMP24_GP25L PF01105.24 AET38076.1 - 1.4e-44 152.3 0.0 1.7e-44 152.0 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD PH_3 PF14593.6 AET38076.1 - 0.06 13.5 0.1 0.087 12.9 0.1 1.2 1 0 0 1 1 1 0 PH domain Metallophos PF00149.28 AET38077.1 - 3.1e-40 138.9 0.0 4e-40 138.5 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 AET38077.1 - 1.5e-22 79.8 2.0 1.9e-22 79.4 0.7 1.9 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Kelch_4 PF13418.6 AET38078.1 - 2.4e-15 56.2 1.5 3.2e-05 23.9 0.0 5.3 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.6 AET38078.1 - 7.2e-14 51.5 0.5 2.3e-06 27.7 0.0 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 AET38078.1 - 4.2e-10 39.0 2.5 0.0014 18.1 0.0 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 AET38078.1 - 2.3e-06 27.4 0.2 0.00062 19.7 0.1 3.0 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 AET38078.1 - 0.00017 21.4 1.3 0.034 14.1 0.1 3.7 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 AET38078.1 - 0.031 14.6 3.8 2.8 8.3 0.0 4.8 6 0 0 6 6 6 0 Galactose oxidase, central domain BPS1 PF05633.11 AET38078.1 - 3.1 6.7 4.7 6.3 5.7 4.7 1.4 1 0 0 1 1 1 0 Protein BYPASS1-related HEAT_EZ PF13513.6 AET38079.1 - 8e-30 102.9 22.1 0.00015 22.2 0.0 16.1 13 5 4 17 17 16 7 HEAT-like repeat HEAT PF02985.22 AET38079.1 - 5.7e-29 97.7 26.1 0.033 14.4 0.0 21.3 24 0 0 24 24 22 5 HEAT repeat Gcn1_N PF12074.8 AET38079.1 - 9.9e-27 94.2 11.5 2.6e-15 56.6 0.2 4.9 5 0 0 5 5 5 2 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT_2 PF13646.6 AET38079.1 - 7.9e-26 90.3 18.6 0.0004 20.7 1.2 12.3 9 4 4 13 13 13 6 HEAT repeats CLASP_N PF12348.8 AET38079.1 - 8e-19 68.1 0.1 3.1e-05 23.6 0.0 7.5 6 2 1 7 7 7 4 CLASP N terminal Cnd1 PF12717.7 AET38079.1 - 1.2e-15 57.9 26.6 0.061 13.4 0.3 11.4 7 3 6 13 13 13 6 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 AET38079.1 - 3.6e-10 40.3 2.3 0.13 12.9 0.0 8.5 7 2 1 8 8 7 2 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 AET38079.1 - 0.007 16.3 16.0 1.4 8.8 0.0 8.6 7 1 0 8 8 8 1 Domain of unknown function (DUF3385) Alpha_Helical PF18489.1 AET38079.1 - 0.018 15.2 0.1 0.095 12.9 0.1 2.3 1 0 0 1 1 1 0 Alpha helical domain Nipped-B_C PF12830.7 AET38079.1 - 0.043 13.7 0.8 11 5.9 0.0 5.0 4 1 1 5 5 5 0 Sister chromatid cohesion C-terminus NUC173 PF08161.12 AET38079.1 - 0.086 12.5 1.0 27 4.3 0.0 4.9 5 1 0 5 5 5 0 NUC173 domain FPL PF09758.9 AET38079.1 - 0.11 12.5 6.7 2.8 8.0 0.7 4.5 4 0 0 4 4 4 0 Uncharacterised conserved protein MSP7_C PF12948.7 AET38079.1 - 0.29 11.8 3.7 1 10.1 0.3 3.6 2 1 1 3 3 3 0 MSP7-like protein C-terminal domain rhaM PF05336.13 AET38079.1 - 0.38 10.8 1.4 2 8.5 0.4 2.4 2 0 0 2 2 2 0 L-rhamnose mutarotase RTP1_C1 PF10363.9 AET38079.1 - 1.3 9.2 14.6 27 5.0 0.4 7.3 8 1 0 8 8 8 0 Required for nuclear transport of RNA pol II C-terminus 1 FANCI_S2 PF14676.6 AET38079.1 - 2.1 8.6 10.0 7.5 6.8 0.3 5.3 5 0 0 5 5 5 0 FANCI solenoid 2 Zn_clus PF00172.18 AET38080.1 - 7.6e-08 32.4 10.1 1.7e-07 31.3 10.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Siva PF05458.12 AET38080.1 - 0.56 9.9 7.0 0.62 9.7 4.8 1.9 2 0 0 2 2 2 0 Cd27 binding protein (Siva) Hist_deacetyl PF00850.19 AET38081.1 - 4.5e-84 282.5 0.0 5.8e-84 282.2 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain RPAP2_Rtr1 PF04181.13 AET38083.1 - 1.1e-17 64.1 1.4 1.8e-17 63.4 1.4 1.4 1 0 0 1 1 1 1 Rtr1/RPAP2 family DUF2574 PF10836.8 AET38083.1 - 0.03 14.2 0.0 0.052 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2574) DUF747 PF05346.11 AET38084.1 - 4.1e-85 286.1 19.6 7.6e-85 285.2 19.6 1.3 1 1 0 1 1 1 1 Eukaryotic membrane protein family DUF5345 PF17280.2 AET38084.1 - 3 7.9 9.7 1.1 9.3 0.2 3.7 3 0 0 3 3 3 0 Family of unknown function (DUF5345) zf-UBR PF02207.20 AET38085.1 - 1.3e-10 41.3 14.2 1.3e-10 41.3 14.2 3.4 2 1 1 3 3 3 2 Putative zinc finger in N-recognin (UBR box) MCM PF00493.23 AET38086.1 - 3.9e-102 340.1 0.1 5.8e-102 339.5 0.1 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AET38086.1 - 1.3e-36 125.2 0.0 2.3e-36 124.4 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AET38086.1 - 1.5e-25 89.4 0.2 4e-25 88.0 0.2 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM2_N PF12619.8 AET38086.1 - 3.1e-25 89.3 30.2 3.1e-25 89.3 30.2 3.6 4 0 0 4 4 4 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.6 AET38086.1 - 8.7e-12 45.6 0.1 2.5e-11 44.1 0.1 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 AET38086.1 - 5.4e-09 35.7 0.0 5.5e-07 29.2 0.0 2.5 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 AET38086.1 - 6.2e-07 29.5 0.0 1.3e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 AET38086.1 - 0.00091 19.1 0.0 0.0036 17.2 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 AET38086.1 - 0.0019 17.9 0.1 0.011 15.4 0.1 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA PF00004.29 AET38086.1 - 0.018 15.5 0.0 0.069 13.6 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 AET38086.1 - 0.056 13.1 0.2 0.11 12.2 0.2 1.4 1 0 0 1 1 1 0 AAA domain SelR PF01641.18 AET38086.1 - 0.1 12.7 0.1 3.6 7.7 0.1 2.5 2 0 0 2 2 2 0 SelR domain Yippee-Mis18 PF03226.14 AET38086.1 - 0.17 12.1 0.1 0.39 10.9 0.1 1.5 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Methyltr_RsmB-F PF01189.17 AET38087.1 - 6.2e-42 143.5 0.0 3.3e-41 141.1 0.0 2.0 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 AET38087.1 - 0.0013 18.9 0.0 0.0024 18.0 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase UAF_Rrn10 PF05234.11 AET38088.1 - 8.7e-27 93.8 0.0 1.1e-26 93.5 0.0 1.1 1 0 0 1 1 1 1 UAF complex subunit Rrn10 V_ATPase_I PF01496.19 AET38089.1 - 4.1e-300 997.5 3.0 4.8e-300 997.3 3.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family WD40 PF00400.32 AET38090.1 - 8e-18 64.5 19.3 0.00021 22.0 1.3 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat Nup160 PF11715.8 AET38090.1 - 0.002 16.9 1.2 0.57 8.8 0.1 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 LPP PF04728.13 AET38090.1 - 0.04 14.3 0.1 0.076 13.4 0.1 1.4 1 0 0 1 1 1 0 Lipoprotein leucine-zipper Pkinase PF00069.25 AET38091.1 - 2.7e-47 161.4 0.1 1.2e-43 149.4 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AET38091.1 - 1.2e-19 70.6 0.2 2.9e-19 69.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 AET38091.1 - 0.063 13.2 0.3 0.4 10.6 0.0 2.3 3 0 0 3 3 3 0 Phosphotransferase enzyme family NEMP PF10225.9 AET38091.1 - 0.83 9.3 3.4 0.36 10.4 0.2 1.9 2 0 0 2 2 2 0 NEMP family TBCA PF02970.16 AET38093.1 - 1.6e-24 86.1 6.1 1.9e-24 85.8 6.1 1.1 1 0 0 1 1 1 1 Tubulin binding cofactor A MA-Mit PF09245.10 AET38093.1 - 0.01 15.4 0.8 0.014 14.9 0.7 1.4 1 1 0 1 1 1 0 Mycoplasma arthritidis-derived mitogen Hemagglutinin PF00509.18 AET38093.1 - 0.038 12.4 0.8 0.047 12.1 0.8 1.0 1 0 0 1 1 1 0 Haemagglutinin PdaC PF13739.6 AET38093.1 - 0.18 12.8 3.9 0.21 12.6 0.7 2.0 1 1 1 2 2 2 0 Deacetylase PdaC DUF2353 PF09789.9 AET38093.1 - 0.18 11.1 7.0 0.43 9.9 7.0 1.6 1 1 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) DUF3450 PF11932.8 AET38093.1 - 0.43 9.8 6.4 1.4 8.1 6.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) ATP_bind_1 PF03029.17 AET38095.1 - 1.7e-78 263.7 0.1 2.2e-78 263.4 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 AET38095.1 - 0.0094 15.0 0.0 0.019 13.9 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 AET38095.1 - 0.046 13.9 0.2 0.12 12.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain KTI12 PF08433.10 AET38095.1 - 0.064 12.7 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_31 PF13614.6 AET38095.1 - 0.13 12.2 0.0 18 5.2 0.0 2.4 1 1 0 2 2 2 0 AAA domain CbiA PF01656.23 AET38095.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain MitMem_reg PF13012.6 AET38096.1 - 5.8e-32 110.4 0.4 1.2e-31 109.4 0.4 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 AET38096.1 - 1.5e-31 108.8 0.0 2.5e-31 108.1 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UbiA PF01040.18 AET38097.1 - 1.2e-48 165.6 16.3 1.2e-48 165.6 16.3 1.3 1 1 0 1 1 1 1 UbiA prenyltransferase family NicO PF03824.16 AET38097.1 - 0.094 12.0 1.5 1.5 8.1 0.5 2.2 2 0 0 2 2 2 0 High-affinity nickel-transport protein AAA PF00004.29 AET38098.1 - 1.2e-42 145.5 0.0 2.3e-42 144.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AET38098.1 - 2e-09 37.1 0.1 4.6e-09 35.9 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 AET38098.1 - 2.6e-08 34.4 0.1 1.5e-05 25.5 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 AET38098.1 - 1e-06 28.8 0.1 3e-05 24.1 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Prot_ATP_ID_OB PF16450.5 AET38098.1 - 4.1e-06 26.6 0.3 4.1e-06 26.6 0.3 1.7 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 AET38098.1 - 3e-05 24.2 0.0 0.0001 22.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 AET38098.1 - 5.7e-05 22.9 0.0 0.00013 21.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 AET38098.1 - 0.00015 21.8 0.0 0.00027 20.9 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 AET38098.1 - 0.0015 18.8 0.1 0.027 14.7 0.1 2.4 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 AET38098.1 - 0.0016 17.7 0.1 0.0031 16.8 0.1 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain RNA_helicase PF00910.22 AET38098.1 - 0.0019 18.6 0.0 0.0049 17.2 0.0 1.7 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 AET38098.1 - 0.0048 16.3 0.1 0.01 15.2 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 AET38098.1 - 0.0066 17.0 0.1 0.028 15.0 0.0 2.2 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 AET38098.1 - 0.0076 16.0 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 AET38098.1 - 0.011 16.0 0.0 0.024 14.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 AET38098.1 - 0.013 15.2 0.6 0.029 14.1 0.0 1.9 3 0 0 3 3 2 0 AAA domain ATPase PF06745.13 AET38098.1 - 0.016 14.6 1.0 0.045 13.1 0.0 2.3 3 0 0 3 3 3 0 KaiC AAA_28 PF13521.6 AET38098.1 - 0.021 15.1 0.1 0.065 13.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 AET38098.1 - 0.031 14.1 3.4 0.52 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 AET38098.1 - 0.036 13.6 0.0 0.083 12.4 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region Fib_alpha PF08702.10 AET38098.1 - 0.037 14.2 1.1 0.091 13.0 1.1 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family PhoH PF02562.16 AET38098.1 - 0.038 13.4 0.1 0.077 12.4 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_14 PF13173.6 AET38098.1 - 0.05 13.6 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AET38098.1 - 0.058 13.0 0.1 0.19 11.3 0.1 1.8 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 AET38098.1 - 0.075 12.7 0.2 0.32 10.7 0.0 2.0 2 1 0 2 2 2 0 Sigma-54 interaction domain GAS PF13851.6 AET38098.1 - 0.082 12.3 6.8 0.16 11.3 6.8 1.5 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Parvo_NS1 PF01057.17 AET38098.1 - 0.085 11.9 0.1 0.17 10.9 0.1 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_3 PF07726.11 AET38098.1 - 0.1 12.4 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Atg14 PF10186.9 AET38098.1 - 1.8 7.6 6.0 2.6 7.0 6.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 OmpH PF03938.14 AET38098.1 - 2 8.7 11.6 1.1 9.6 7.9 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) AAA_23 PF13476.6 AET38098.1 - 5.3 7.5 12.0 12 6.3 0.1 2.6 2 1 0 2 2 2 0 AAA domain EF-hand_1 PF00036.32 AET38100.1 - 5.7e-26 88.1 16.2 4.3e-08 32.1 0.2 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 AET38100.1 - 6.3e-26 90.6 12.4 5.8e-16 58.7 1.7 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AET38100.1 - 2e-20 70.9 12.7 3.2e-07 29.7 0.3 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 AET38100.1 - 3.9e-18 65.0 15.2 1.4e-10 40.9 0.6 3.9 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 AET38100.1 - 2.7e-14 51.9 7.7 2.6e-05 23.5 0.1 3.8 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.7 AET38100.1 - 6.6e-09 35.7 1.5 0.00018 21.4 0.1 2.2 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 AET38100.1 - 1.3e-08 35.1 1.0 5.9e-05 23.3 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_14 PF17959.1 AET38100.1 - 0.00021 21.6 0.7 0.13 12.6 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain Dockerin_1 PF00404.18 AET38100.1 - 0.0028 17.8 0.4 3.1 8.1 0.1 2.4 2 0 0 2 2 2 2 Dockerin type I domain SPARC_Ca_bdg PF10591.9 AET38100.1 - 0.0074 16.6 0.6 1.1 9.6 0.0 2.1 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region SUB1_ProdP9 PF18213.1 AET38100.1 - 0.015 15.2 0.3 0.033 14.0 0.3 1.6 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 DUF1296 PF06972.11 AET38100.1 - 0.025 14.7 0.4 2.4 8.3 0.1 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1296) Caleosin PF05042.13 AET38100.1 - 0.04 13.9 1.2 2 8.3 0.1 3.0 1 1 3 4 4 4 0 Caleosin related protein MgtE_N PF03448.17 AET38100.1 - 0.05 14.2 2.7 0.092 13.4 0.2 2.4 3 0 0 3 3 3 0 MgtE intracellular N domain VCBS PF13517.6 AET38100.1 - 0.082 13.5 0.9 1.7 9.3 0.0 2.3 2 1 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PhetRS_B1 PF18262.1 AET38100.1 - 0.1 12.8 0.5 0.1 12.8 0.5 2.0 2 1 0 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain CAP_GLY PF01302.25 AET38101.1 - 3.7e-21 74.9 0.8 5.9e-21 74.3 0.8 1.3 1 0 0 1 1 1 1 CAP-Gly domain ATG16 PF08614.11 AET38101.1 - 1.1 9.5 47.5 2.4 8.3 10.3 2.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) GAS PF13851.6 AET38101.1 - 1.4 8.2 46.1 0.32 10.3 14.2 3.5 1 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding DUF1216 PF06746.11 AET38101.1 - 2.4 8.2 17.5 5.5 7.0 6.5 3.9 2 1 2 4 4 4 0 Protein of unknown function (DUF1216) DUF4201 PF13870.6 AET38101.1 - 5.9 6.6 41.1 26 4.5 16.3 4.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) MSV199 PF10553.9 AET38101.1 - 7.9 6.7 12.3 0.81 9.9 4.0 2.8 2 1 0 2 2 2 0 MSV199 domain Spc7 PF08317.11 AET38101.1 - 9.7 5.0 47.6 1.3 7.9 20.7 3.4 1 1 2 3 3 3 0 Spc7 kinetochore protein PIGA PF08288.12 AET38102.1 - 4.5e-45 152.2 3.6 1.7e-44 150.3 3.6 2.1 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 AET38102.1 - 3.3e-30 105.3 3.6 3.8e-30 105.1 1.5 2.0 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 AET38102.1 - 1.8e-27 96.0 0.0 2.8e-27 95.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AET38102.1 - 7.7e-20 71.7 0.1 1.6e-19 70.7 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 AET38102.1 - 6.4e-12 46.2 0.0 1.5e-11 45.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 AET38102.1 - 0.023 15.1 0.0 0.047 14.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 TFR_dimer PF04253.15 AET38103.1 - 1.2e-29 102.9 0.1 2.1e-29 102.1 0.1 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Cyt-b5 PF00173.28 AET38104.1 - 1.3e-14 54.1 0.1 2.3e-14 53.3 0.1 1.5 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain RRM_9 PF18444.1 AET38106.1 - 3.1e-29 100.6 0.1 7e-29 99.5 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif TAP_C PF03943.13 AET38106.1 - 1e-12 47.5 1.8 2.1e-12 46.4 0.0 2.4 2 0 0 2 2 2 1 TAP C-terminal domain LRR_9 PF14580.6 AET38106.1 - 3e-09 36.6 0.9 5.5e-09 35.8 0.9 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 AET38106.1 - 0.00037 20.8 5.6 0.0042 17.5 2.8 2.7 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) Desmo_N PF06771.11 AET38106.1 - 0.099 13.0 0.1 0.27 11.6 0.1 1.7 1 0 0 1 1 1 0 Viral Desmoplakin N-terminus DnaJ PF00226.31 AET38107.1 - 1.3e-14 54.1 0.3 3.5e-14 52.7 0.3 1.8 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 AET38107.1 - 0.0092 15.2 0.2 0.091 11.9 0.1 2.2 1 1 1 2 2 2 1 Sec63 Brl domain Acetyltransf_1 PF00583.25 AET38108.1 - 4.6e-15 55.9 0.0 6.7e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AET38108.1 - 6.8e-13 48.7 0.0 9.1e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AET38108.1 - 3.2e-11 43.5 0.1 4.2e-11 43.1 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 AET38108.1 - 7e-05 23.0 0.0 8.4e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AET38108.1 - 0.00093 19.1 0.0 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_15 PF17013.5 AET38108.1 - 0.053 13.0 0.1 0.065 12.7 0.1 1.3 1 0 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_9 PF13527.7 AET38108.1 - 0.086 12.9 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 AET38108.1 - 0.087 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Tma16 PF11176.8 AET38110.1 - 3e-48 163.4 5.0 3.5e-48 163.2 5.0 1.0 1 0 0 1 1 1 1 Translation machinery-associated protein 16 Mit_ribos_Mrp51 PF11709.8 AET38110.1 - 0.15 11.6 5.7 0.19 11.3 5.7 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit DNA_pol_B PF00136.21 AET38111.1 - 2.2e-104 349.8 1.4 2.9e-104 349.3 1.4 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 AET38111.1 - 2.7e-19 69.5 0.3 1.9e-11 43.7 0.2 2.7 2 1 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 AET38111.1 - 1.6e-10 41.3 7.3 3.4e-10 40.2 7.3 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta Atg29_N PF18388.1 AET38112.1 - 5.3e-19 67.8 1.3 9.6e-19 67.0 1.3 1.5 1 0 0 1 1 1 1 Atg29 N-terminal domain SET PF00856.28 AET38113.1 - 7.1e-11 42.8 3.3 3.3e-10 40.6 3.3 1.9 1 1 0 1 1 1 1 SET domain SmpA_OmlA PF04355.13 AET38113.1 - 0.16 11.8 0.0 0.75 9.6 0.0 1.9 2 0 0 2 2 2 0 SmpA / OmlA family Rhodanese PF00581.20 AET38114.1 - 1.2e-18 67.6 0.0 3.4e-08 34.0 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain CLP1_P PF16575.5 AET38115.1 - 2.4e-32 112.3 0.0 3.8e-32 111.6 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 AET38115.1 - 4.6e-27 94.8 0.1 7.8e-27 94.0 0.1 1.4 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_N PF16573.5 AET38115.1 - 5.1e-23 81.1 0.0 1.3e-22 79.8 0.0 1.7 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor AAA_16 PF13191.6 AET38115.1 - 0.0012 19.3 0.0 0.0023 18.3 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 AET38115.1 - 0.0078 16.6 0.0 0.018 15.4 0.0 1.6 1 0 0 1 1 1 1 RNA helicase MMR_HSR1 PF01926.23 AET38115.1 - 0.0089 16.1 0.1 0.047 13.8 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 AET38115.1 - 0.011 15.5 0.1 0.018 14.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AET38115.1 - 0.013 16.0 0.1 0.029 14.9 0.1 1.6 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 AET38115.1 - 0.015 14.9 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Septin PF00735.18 AET38115.1 - 0.025 13.9 0.0 0.053 12.8 0.0 1.5 1 0 0 1 1 1 0 Septin PduV-EutP PF10662.9 AET38115.1 - 0.026 14.3 0.0 0.06 13.1 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 AET38115.1 - 0.034 13.9 0.0 0.085 12.6 0.0 1.6 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 AET38115.1 - 0.043 14.0 0.2 0.12 12.6 0.2 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 AET38115.1 - 0.077 12.8 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 AET38115.1 - 0.078 13.2 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 AET38115.1 - 0.11 13.0 0.1 0.27 11.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 AET38115.1 - 0.12 11.8 0.0 0.4 10.1 0.0 1.8 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit G-alpha PF00503.20 AET38115.1 - 0.15 11.2 0.0 0.32 10.1 0.0 1.4 2 0 0 2 2 2 0 G-protein alpha subunit AAA_28 PF13521.6 AET38115.1 - 0.18 12.0 0.1 0.39 10.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain ANAPC5 PF12862.7 AET38116.1 - 1.7e-19 69.7 0.1 1.7e-19 69.7 0.1 2.9 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 5 CM1 PF03026.15 AET38116.1 - 0.08 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Influenza C virus M1 protein HATPase_c_3 PF13589.6 AET38117.1 - 5.1e-11 42.5 0.0 1.2e-10 41.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.11 AET38117.1 - 3.1e-09 36.7 0.0 2.3e-07 30.7 0.0 2.4 1 1 1 2 2 2 2 MutL C terminal dimerisation domain HATPase_c PF02518.26 AET38117.1 - 5.4e-08 33.3 0.1 1.2e-07 32.2 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase T4-gp15_tss PF16724.5 AET38118.1 - 0.0071 16.1 0.7 0.025 14.4 0.2 1.9 1 1 1 2 2 2 1 T4-like virus Myoviridae tail sheath stabiliser A_deaminase PF00962.22 AET38118.1 - 0.29 10.4 2.5 0.37 10.1 1.2 1.7 1 1 1 2 2 2 0 Adenosine/AMP deaminase STIMATE PF12400.8 AET38119.1 - 2.2e-43 147.7 8.1 2.2e-43 147.7 8.1 1.7 2 0 0 2 2 2 1 STIMATE family DUF2208 PF09973.9 AET38119.1 - 0.059 13.0 2.0 0.11 12.1 2.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) DUF4168 PF13767.6 AET38119.1 - 0.12 13.5 0.2 0.21 12.8 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4168) DUF4728 PF15860.5 AET38119.1 - 0.34 11.6 5.9 6.5 7.5 0.4 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4728) BP28CT PF08146.12 AET38120.1 - 0.014 15.2 0.1 0.24 11.3 0.1 2.8 2 0 0 2 2 2 0 BP28CT (NUC211) domain Nse4_C PF08743.10 AET38120.1 - 0.11 12.8 0.3 0.24 11.7 0.3 1.5 1 0 0 1 1 1 0 Nse4 C-terminal adh_short PF00106.25 AET38121.1 - 7.9e-25 87.5 0.1 6.7e-12 45.3 0.0 3.1 2 1 1 3 3 3 3 short chain dehydrogenase adh_short_C2 PF13561.6 AET38121.1 - 1.5e-13 50.9 0.0 1.9e-09 37.4 0.0 3.0 2 1 1 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AET38121.1 - 0.0043 17.0 0.0 0.0087 16.0 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AET38121.1 - 0.091 12.2 0.0 0.15 11.5 0.0 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family tRNA-synt_1 PF00133.22 AET38122.1 - 2.1e-45 155.1 0.0 1.2e-36 126.1 0.0 2.7 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 AET38122.1 - 4.9e-17 61.8 0.3 1.9e-09 36.7 0.0 3.7 4 0 0 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 AET38122.1 - 3.8e-11 43.2 0.0 1.5e-10 41.3 0.0 2.0 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 AET38122.1 - 1.5e-06 27.8 0.0 3.1e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Pet20 PF08692.10 AET38123.1 - 1.5e-09 38.6 9.5 0.00034 21.3 0.0 3.5 3 1 1 4 4 4 2 Mitochondrial protein Pet20 G2BR PF18442.1 AET38123.1 - 0.059 13.0 1.3 0.14 11.9 1.3 1.6 1 0 0 1 1 1 0 E3 gp78 Ube2g2-binding region (G2BR) Abhydrolase_1 PF00561.20 AET38124.1 - 1.5e-14 54.3 0.0 3.6e-14 53.0 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AET38124.1 - 2e-07 30.5 0.0 3.9e-07 29.6 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Lipase_3 PF01764.25 AET38124.1 - 0.0021 17.9 0.0 0.0064 16.4 0.0 1.8 2 0 0 2 2 2 1 Lipase (class 3) Abhydrolase_6 PF12697.7 AET38124.1 - 0.012 16.3 0.0 0.018 15.7 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Lipase PF00151.19 AET38124.1 - 0.022 14.1 0.0 0.058 12.7 0.0 1.5 2 0 0 2 2 2 0 Lipase DUF915 PF06028.11 AET38124.1 - 0.11 11.8 0.0 0.26 10.6 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Cutinase PF01083.22 AET38124.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Cutinase Methyltransf_15 PF09445.10 AET38126.1 - 1.9e-61 206.4 0.0 2.5e-61 206.0 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_31 PF13847.6 AET38126.1 - 8.7e-05 22.4 0.0 0.00013 21.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AET38126.1 - 0.0001 22.9 0.0 0.0002 22.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AET38126.1 - 0.00032 20.3 0.0 0.00057 19.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain UPF0020 PF01170.18 AET38126.1 - 0.0013 18.5 0.2 0.0053 16.5 0.2 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 MethyltransfD12 PF02086.15 AET38126.1 - 0.0024 17.6 0.0 0.0049 16.6 0.0 1.5 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase Methyltr_RsmB-F PF01189.17 AET38126.1 - 0.008 15.8 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Cons_hypoth95 PF03602.15 AET38126.1 - 0.013 15.2 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 DNA_methylase PF00145.17 AET38126.1 - 0.059 12.7 0.0 0.099 12.0 0.0 1.3 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase tRNA_U5-meth_tr PF05958.11 AET38126.1 - 0.12 11.3 0.0 0.18 10.7 0.0 1.3 1 1 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Kinesin PF00225.23 AET38128.1 - 4.8e-105 351.2 0.7 4.8e-105 351.2 0.7 1.6 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 AET38128.1 - 1.8e-26 92.8 0.1 5.5e-26 91.3 0.1 1.8 1 0 0 1 1 1 1 Microtubule binding TMF_DNA_bd PF12329.8 AET38128.1 - 1.3 9.1 15.7 1.2 9.2 2.9 4.5 4 0 0 4 4 4 0 TATA element modulatory factor 1 DNA binding DUF722 PF05263.11 AET38128.1 - 1.5 9.1 10.4 5.5 7.2 2.6 3.0 2 2 1 3 3 3 0 Protein of unknown function (DUF722) AAA_17 PF13207.6 AET38128.1 - 3.2 8.2 5.9 9.3 6.7 0.0 3.4 2 1 1 3 3 3 0 AAA domain Asp PF00026.23 AET38129.1 - 1.4e-98 330.2 0.2 1.7e-98 330.0 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AET38129.1 - 2.4e-13 50.7 1.0 2.3e-10 41.0 0.5 2.6 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 AET38129.1 - 2e-06 27.7 0.0 0.00055 19.8 0.0 2.6 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 AET38129.1 - 2.9e-05 24.6 0.0 0.025 15.2 0.0 3.2 2 2 0 2 2 2 2 Aspartyl protease Pkinase PF00069.25 AET38130.1 - 3.4e-78 262.7 0.0 4.9e-78 262.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38130.1 - 2.6e-38 131.8 0.0 4.1e-38 131.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 AET38130.1 - 5.3e-25 87.6 3.5 1.9e-13 50.5 0.2 3.0 3 0 0 3 3 3 2 FHA domain Yop-YscD_cpl PF16697.5 AET38130.1 - 5.4e-11 42.6 0.1 1.9e-08 34.5 0.0 2.7 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Kinase-like PF14531.6 AET38130.1 - 1.3e-08 34.6 0.0 2.5e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like FHA_2 PF17913.1 AET38130.1 - 4.8e-07 29.9 0.2 0.056 13.7 0.0 3.6 3 0 0 3 3 3 2 FHA domain APH PF01636.23 AET38130.1 - 1.8e-05 24.8 0.8 0.016 15.1 0.0 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 AET38130.1 - 1.9e-05 24.1 0.0 3.4e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 AET38130.1 - 0.0029 17.2 0.0 0.0055 16.3 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 AET38130.1 - 0.059 12.3 0.6 0.094 11.6 0.0 1.6 2 0 0 2 2 2 0 Haspin like kinase domain Mucin PF01456.17 AET38130.1 - 2.6 8.0 19.9 5.7 6.9 19.9 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein DAGAT PF03982.13 AET38131.1 - 5.3e-84 281.6 3.9 4.9e-75 252.2 0.2 2.1 2 0 0 2 2 2 2 Diacylglycerol acyltransferase PTPA PF03095.15 AET38132.1 - 1.8e-117 392.1 0.5 2.1e-117 391.9 0.5 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein MOZ_SAS PF01853.18 AET38133.1 - 5.4e-82 273.8 0.2 7.8e-82 273.3 0.2 1.2 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.8 AET38133.1 - 1.1e-22 79.7 0.1 2.2e-22 78.7 0.1 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain zf-MYST PF17772.1 AET38133.1 - 9.7e-21 73.1 0.2 2.6e-20 71.8 0.2 1.8 1 0 0 1 1 1 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 AET38133.1 - 0.0015 19.0 0.0 0.0039 17.6 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 AET38133.1 - 0.0073 16.5 0.0 0.021 15.1 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family WD40 PF00400.32 AET38134.1 - 8.7e-32 108.7 18.6 1.6e-06 28.7 1.1 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET38134.1 - 1.7e-07 31.4 1.0 0.26 11.6 0.2 4.6 3 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 AET38134.1 - 5.6e-05 22.1 3.3 0.46 9.2 0.0 4.6 1 1 2 4 4 4 3 Nup133 N terminal like Nup160 PF11715.8 AET38134.1 - 0.0054 15.4 6.5 1.3 7.6 0.1 4.3 1 1 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 AET38134.1 - 0.0058 16.0 0.0 0.077 12.3 0.0 2.3 2 0 0 2 2 2 1 WD40-like domain TruD PF01142.18 AET38135.1 - 2.6e-78 263.7 0.4 5e-72 243.0 0.1 3.2 2 2 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) SEA PF01390.20 AET38135.1 - 0.75 9.9 3.1 6.5 6.9 0.0 3.3 4 0 0 4 4 4 0 SEA domain Dehydratase_SU PF02287.15 AET38135.1 - 1 9.5 4.4 1.4 9.0 0.0 3.1 3 1 1 4 4 4 0 Dehydratase small subunit DUF2971 PF11185.8 AET38135.1 - 3.6 8.8 5.3 1.9 9.7 0.2 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF2971) RRM_1 PF00076.22 AET38136.1 - 0.011 15.5 0.0 0.046 13.5 0.0 2.0 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mur_ligase_M PF08245.12 AET38137.1 - 4.2e-06 26.9 1.2 0.0055 16.7 0.0 2.9 2 1 1 3 3 3 2 Mur ligase middle domain Mur_ligase_C PF02875.21 AET38137.1 - 0.01 16.0 0.0 0.027 14.7 0.0 1.7 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain MCRA PF06100.11 AET38137.1 - 0.019 13.8 0.2 0.75 8.5 0.1 2.1 2 0 0 2 2 2 0 MCRA family Pkinase PF00069.25 AET38138.1 - 1.3e-63 214.8 0.0 2.1e-63 214.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38138.1 - 7.5e-35 120.5 0.0 1.2e-34 119.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET38138.1 - 1.9e-08 34.0 0.0 4e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 AET38138.1 - 0.0045 16.0 0.0 0.0045 16.0 0.0 3.0 3 0 0 3 3 3 1 Haspin like kinase domain Kdo PF06293.14 AET38138.1 - 0.02 14.3 0.0 0.076 12.3 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family PAP_assoc PF03828.19 AET38138.1 - 0.051 13.8 0.1 0.22 11.7 0.1 2.1 1 0 0 1 1 1 0 Cid1 family poly A polymerase APH PF01636.23 AET38138.1 - 0.23 11.3 0.0 0.43 10.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family SGT1 PF07093.11 AET38139.1 - 7.1e-12 44.6 0.1 7.1e-12 44.6 0.1 2.1 2 0 0 2 2 2 2 SGT1 protein APG5 PF04106.12 AET38140.1 - 2.7e-44 151.4 0.2 3.4e-44 151.1 0.2 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 ACPS PF01648.20 AET38141.1 - 9.3e-14 51.5 0.0 1.6e-13 50.7 0.0 1.5 1 1 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily ABC_membrane_2 PF06472.15 AET38142.1 - 1.2e-83 280.6 7.6 1.2e-83 280.6 7.6 1.8 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 AET38142.1 - 1.1e-14 55.1 0.0 3.3e-14 53.6 0.0 1.9 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.19 AET38142.1 - 0.00032 20.2 0.3 0.036 13.5 0.0 2.2 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 AET38142.1 - 0.71 10.3 4.2 4.4 7.7 4.2 2.1 1 1 0 1 1 1 0 AAA domain Nop53 PF07767.11 AET38144.1 - 3.7e-98 329.6 36.3 4.3e-98 329.3 36.3 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) ZapD PF07072.11 AET38144.1 - 1.5 8.5 8.7 1.1 9.0 4.3 2.4 3 0 0 3 3 3 0 Cell division protein Oxysterol_BP PF01237.18 AET38145.1 - 3.2e-63 213.8 3.6 5e-61 206.6 3.6 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein DUF2746 PF10874.8 AET38145.1 - 0.2 12.1 0.2 91 3.6 0.0 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2746) DHFR_1 PF00186.19 AET38146.1 - 1.9e-25 89.5 0.0 2.9e-25 88.9 0.0 1.4 1 0 0 1 1 1 1 Dihydrofolate reductase POC3_POC4 PF10448.9 AET38147.1 - 8.6e-12 45.3 0.1 9.3e-12 45.2 0.1 1.1 1 0 0 1 1 1 1 20S proteasome chaperone assembly proteins 3 and 4 PAC4 PF16093.5 AET38147.1 - 4.9e-06 26.6 0.0 7e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 Pyr_redox_3 PF13738.6 AET38148.1 - 7.5e-27 94.4 0.0 1.5e-23 83.5 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 AET38148.1 - 2e-21 76.0 0.8 3.3e-15 55.5 0.1 2.4 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 AET38148.1 - 4.9e-16 58.8 0.0 1.3e-13 50.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 AET38148.1 - 1.5e-14 53.9 0.1 9.2e-12 44.8 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 AET38148.1 - 7.5e-06 25.4 0.1 0.00018 20.9 0.1 2.2 2 0 0 2 2 2 1 FAD binding domain NAD_binding_7 PF13241.6 AET38148.1 - 0.00027 21.3 0.0 0.52 10.8 0.0 2.6 2 1 0 2 2 2 2 Putative NAD(P)-binding NAD_binding_8 PF13450.6 AET38148.1 - 0.00032 20.9 1.7 0.0018 18.4 0.1 2.8 3 0 0 3 3 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 AET38148.1 - 0.00059 19.5 0.1 0.26 10.8 0.1 3.1 3 0 0 3 3 3 1 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 AET38148.1 - 0.00076 18.9 0.1 0.027 13.8 0.0 2.2 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 AET38148.1 - 0.0021 18.6 0.5 0.78 10.3 0.1 3.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 AET38148.1 - 0.0026 17.8 0.0 3.6 7.7 0.0 2.6 3 0 0 3 3 2 2 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 AET38148.1 - 0.0067 15.5 0.2 0.017 14.2 0.2 1.6 2 0 0 2 2 2 1 FAD binding domain Amino_oxidase PF01593.24 AET38148.1 - 0.049 12.9 0.0 7.8 5.7 0.0 2.4 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 AET38148.1 - 0.079 12.0 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein adh_short PF00106.25 AET38148.1 - 0.092 12.2 0.1 11 5.4 0.0 2.4 2 0 0 2 2 2 0 short chain dehydrogenase NAD_binding_9 PF13454.6 AET38148.1 - 0.13 12.3 0.2 40 4.1 0.0 3.2 3 0 0 3 3 3 0 FAD-NAD(P)-binding TrkA_N PF02254.18 AET38148.1 - 0.13 12.6 0.1 0.39 11.0 0.0 1.8 2 0 0 2 2 1 0 TrkA-N domain Ribosomal_S25 PF03297.15 AET38149.1 - 4.5e-40 135.9 5.8 5.1e-40 135.8 5.8 1.0 1 0 0 1 1 1 1 S25 ribosomal protein FtsK_gamma PF09397.10 AET38149.1 - 0.00079 19.2 0.0 0.0013 18.5 0.0 1.3 1 0 0 1 1 1 1 Ftsk gamma domain EAP30 PF04157.16 AET38149.1 - 0.018 14.3 0.0 0.023 14.0 0.0 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family HTH_CodY PF08222.11 AET38149.1 - 0.048 13.2 0.1 0.074 12.6 0.1 1.2 1 0 0 1 1 1 0 CodY helix-turn-helix domain UPF0121 PF03661.13 AET38150.1 - 0.0055 16.1 17.6 0.006 16.0 8.6 2.9 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0121) Thg1 PF04446.12 AET38151.1 - 4.8e-50 168.8 0.5 6.5e-50 168.3 0.5 1.2 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 AET38151.1 - 2.3e-36 124.6 0.8 4.4e-36 123.7 0.2 1.7 2 0 0 2 2 2 1 Thg1 C terminal domain Imm6 PF14434.6 AET38152.1 - 0.037 14.0 0.5 0.12 12.3 0.1 2.0 2 0 0 2 2 2 0 Immunity protein Imm6 Cu-oxidase PF00394.22 AET38152.1 - 0.062 13.4 0.0 6.2 6.9 0.0 2.3 2 0 0 2 2 2 0 Multicopper oxidase RNA_pol_Rpb2_6 PF00562.28 AET38153.1 - 1.3e-114 383.3 0.0 2.9e-114 382.2 0.0 1.6 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 AET38153.1 - 6.2e-46 156.5 0.1 8.7e-46 156.0 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 AET38153.1 - 1.7e-34 119.1 0.0 9e-34 116.8 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.16 AET38153.1 - 6.7e-28 96.7 0.0 1.7e-27 95.4 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.12 AET38153.1 - 1.5e-22 79.4 0.0 3e-22 78.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.20 AET38153.1 - 3.3e-16 59.5 0.0 9.6e-15 54.8 0.0 2.7 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 DUF572 PF04502.13 AET38155.1 - 1.9e-44 152.6 25.3 7.4e-44 150.7 25.3 1.7 1 1 0 1 1 1 1 Family of unknown function (DUF572) TF_Zn_Ribbon PF08271.12 AET38155.1 - 0.054 13.0 0.2 0.16 11.5 0.2 1.8 1 0 0 1 1 1 0 TFIIB zinc-binding Mut7-C PF01927.16 AET38155.1 - 0.12 12.5 0.2 0.12 12.5 0.2 1.9 2 0 0 2 2 2 0 Mut7-C RNAse domain zf_UBZ PF18439.1 AET38155.1 - 0.14 11.8 2.9 1.8 8.2 0.2 2.6 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Mu-like_Com PF10122.9 AET38155.1 - 0.23 10.9 0.8 0.56 9.7 0.1 2.0 2 0 0 2 2 2 0 Mu-like prophage protein Com zf-ACC PF17848.1 AET38155.1 - 0.34 11.0 2.4 0.41 10.8 0.3 2.2 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain MBR1 PF17058.5 AET38156.1 - 2e-47 162.2 5.4 2e-47 162.2 5.4 2.3 3 0 0 3 3 3 1 Mitochondrial biogenesis regulation protein 1 FYVE_2 PF02318.16 AET38156.1 - 0.6 10.3 6.7 8.9 6.6 1.3 2.3 2 0 0 2 2 2 0 FYVE-type zinc finger GRP PF07172.11 AET38156.1 - 2 9.2 7.4 0.1 13.3 1.4 1.8 2 0 0 2 2 2 0 Glycine rich protein family UPF1_Zn_bind PF09416.10 AET38157.1 - 4e-62 208.7 11.9 4e-62 208.7 11.9 2.2 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 AET38157.1 - 3e-57 193.5 0.0 7.9e-57 192.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 AET38157.1 - 2.8e-48 165.0 10.1 1.6e-25 90.4 0.6 2.8 2 1 1 3 3 3 2 AAA domain DUF5599 PF18141.1 AET38157.1 - 9.1e-28 96.3 0.0 2.2e-27 95.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 AET38157.1 - 3.7e-16 59.4 0.1 1.6e-15 57.4 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AET38157.1 - 2.8e-13 50.4 0.1 5.9e-13 49.4 0.1 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 AET38157.1 - 3e-06 27.4 0.0 8.2e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 AET38157.1 - 0.00055 19.8 0.0 0.0014 18.5 0.0 1.7 1 0 0 1 1 1 1 Helicase PhoH PF02562.16 AET38157.1 - 0.0023 17.4 0.0 0.005 16.3 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein DUF2075 PF09848.9 AET38157.1 - 0.0038 16.5 4.4 0.0077 15.5 0.0 3.3 3 2 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 AET38157.1 - 0.0063 16.3 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase PIF1 PF05970.14 AET38157.1 - 0.0088 15.2 0.1 2 7.5 0.1 2.3 1 1 1 2 2 2 1 PIF1-like helicase AAA_23 PF13476.6 AET38157.1 - 0.019 15.5 2.6 0.47 10.9 1.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 AET38157.1 - 0.022 15.0 0.0 0.059 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 AET38157.1 - 0.032 13.3 0.0 0.059 12.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_10 PF12846.7 AET38157.1 - 0.057 12.3 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain SRP54 PF00448.22 AET38157.1 - 0.068 12.8 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Ribosomal_S13_N PF08069.12 AET38157.1 - 0.1 12.7 0.0 0.38 10.8 0.0 2.0 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain ATPase PF06745.13 AET38157.1 - 0.1 11.9 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 KaiC ARF7EP_C PF14949.6 AET38157.1 - 5 7.8 9.7 0.21 12.2 1.9 2.7 3 0 0 3 3 2 0 ARF7 effector protein C-terminus CRAL_TRIO PF00650.20 AET38158.1 - 3.5e-35 121.1 0.0 4.7e-35 120.7 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 AET38158.1 - 2.9e-09 37.0 0.9 6.6e-09 35.8 0.9 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 AET38158.1 - 0.0009 19.4 0.0 0.0014 18.8 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DUF3303 PF11746.8 AET38158.1 - 0.0029 17.8 0.2 0.012 15.9 0.2 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3303) DUF1769 PF08588.10 AET38158.1 - 0.08 13.2 0.1 0.26 11.5 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1769) BACK PF07707.15 AET38158.1 - 0.092 12.8 0.2 0.22 11.7 0.2 1.5 1 0 0 1 1 1 0 BTB And C-terminal Kelch SCAN PF02023.17 AET38158.1 - 0.19 11.6 1.0 1 9.2 0.0 2.5 3 0 0 3 3 3 0 SCAN domain ATP-synt_ab_C PF00306.27 AET38158.1 - 0.2 12.0 0.7 0.69 10.2 0.4 1.9 2 0 0 2 2 2 0 ATP synthase alpha/beta chain, C terminal domain AAA PF00004.29 AET38159.1 - 6.8e-12 45.9 0.2 4.4e-11 43.3 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 AET38159.1 - 1.5e-05 25.0 0.1 0.00013 21.9 0.0 2.3 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 AET38159.1 - 4e-05 24.1 0.0 0.00011 22.6 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 AET38159.1 - 0.00034 20.8 0.0 0.00089 19.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 AET38159.1 - 0.00067 19.4 0.0 0.0019 18.0 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 AET38159.1 - 0.0011 19.3 0.0 0.0027 18.0 0.0 1.7 1 0 0 1 1 1 1 AAA C-terminal domain AAA_14 PF13173.6 AET38159.1 - 0.0012 18.9 0.0 0.0031 17.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AET38159.1 - 0.004 17.4 0.0 0.011 16.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 AET38159.1 - 0.006 16.4 0.4 0.016 15.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_8 PF12780.7 AET38159.1 - 0.035 13.4 0.1 0.58 9.4 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 AAA_5 PF07728.14 AET38159.1 - 0.07 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 AET38159.1 - 0.1 13.1 0.0 0.46 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain IPT PF01745.16 AET38159.1 - 0.13 11.6 0.1 0.23 10.8 0.1 1.3 1 0 0 1 1 1 0 Isopentenyl transferase bZIP_1 PF00170.21 AET38160.1 - 2.5e-08 33.9 16.7 5e-08 32.9 16.7 1.5 1 0 0 1 1 1 1 bZIP transcription factor V_ATPase_I PF01496.19 AET38160.1 - 0.00087 17.4 3.6 0.0011 17.0 3.6 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Glutaredoxin2_C PF04399.13 AET38160.1 - 0.012 15.5 2.1 0.012 15.5 2.1 1.7 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain DUF4201 PF13870.6 AET38160.1 - 0.014 15.2 7.6 0.021 14.6 7.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) CASP_C PF08172.12 AET38160.1 - 0.015 14.6 4.5 0.021 14.2 4.5 1.2 1 0 0 1 1 1 0 CASP C terminal PSI_PsaF PF02507.15 AET38160.1 - 0.016 15.1 0.2 0.026 14.4 0.2 1.2 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III IATP PF04568.12 AET38160.1 - 0.028 14.8 1.4 0.045 14.2 1.4 1.3 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP RIC3 PF15361.6 AET38160.1 - 0.038 14.4 1.1 0.079 13.3 1.1 1.5 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 bHLH-MYC_N PF14215.6 AET38160.1 - 0.042 14.1 0.1 0.059 13.6 0.1 1.2 1 0 0 1 1 1 0 bHLH-MYC and R2R3-MYB transcription factors N-terminal DUF4407 PF14362.6 AET38160.1 - 0.17 11.2 1.7 0.37 10.1 2.2 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) bZIP_2 PF07716.15 AET38160.1 - 0.21 11.7 20.1 0.44 10.7 20.1 1.5 1 0 0 1 1 1 0 Basic region leucine zipper DUF4140 PF13600.6 AET38160.1 - 0.27 11.7 3.6 0.56 10.7 1.9 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) bZIP_Maf PF03131.17 AET38160.1 - 0.3 11.6 9.6 0.52 10.9 9.6 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF349 PF03993.12 AET38160.1 - 0.54 10.6 10.5 0.98 9.8 10.5 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) 2OG-FeII_Oxy_3 PF13640.6 AET38161.1 - 1.2e-09 39.0 0.1 1.8e-09 38.3 0.1 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 AET38161.1 - 0.028 14.9 0.0 0.046 14.2 0.0 1.3 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily CUE PF02845.16 AET38162.1 - 1.6e-13 50.1 0.5 2.6e-09 36.6 0.0 2.8 2 0 0 2 2 2 2 CUE domain DMA PF03474.14 AET38162.1 - 3.1e-08 33.1 0.0 0.014 15.0 0.0 3.7 4 0 0 4 4 4 3 DMRTA motif Smr PF01713.21 AET38162.1 - 1.5e-05 25.2 0.0 3.1e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Smr domain CENP-C_C PF11699.8 AET38163.1 - 2.9e-27 94.7 1.2 6.2e-27 93.6 1.2 1.6 1 0 0 1 1 1 1 Mif2/CENP-C like Mif2_N PF15624.6 AET38163.1 - 1.9e-06 28.6 0.8 1.9e-06 28.6 0.8 3.4 4 1 0 4 4 4 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cupin_2 PF07883.11 AET38163.1 - 0.00058 19.5 0.0 0.0012 18.5 0.0 1.5 1 0 0 1 1 1 1 Cupin domain Dehydrin PF00257.19 AET38163.1 - 0.02 15.5 1.5 0.062 13.9 1.5 1.9 1 0 0 1 1 1 0 Dehydrin AT_hook PF02178.19 AET38163.1 - 0.028 14.3 4.1 0.087 12.7 4.1 1.9 1 0 0 1 1 1 0 AT hook motif Cupin_1 PF00190.22 AET38163.1 - 0.12 12.0 0.1 0.23 11.1 0.1 1.4 1 0 0 1 1 1 0 Cupin Pkinase PF00069.25 AET38164.1 - 4.1e-73 246.0 0.0 1.2e-72 244.5 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38164.1 - 7.4e-47 159.8 0.0 1.5e-46 158.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 AET38164.1 - 1.2e-22 80.0 0.1 1.2e-22 80.0 0.1 2.5 2 0 0 2 2 2 1 P21-Rho-binding domain Kinase-like PF14531.6 AET38164.1 - 1.6e-06 27.7 0.1 2.3e-05 23.8 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 AET38164.1 - 0.2 11.6 0.0 0.2 11.6 0.0 2.9 3 1 1 4 4 4 0 Phosphotransferase enzyme family DSHCT PF08148.12 AET38164.1 - 0.23 11.1 1.5 0.83 9.3 0.0 2.6 3 0 0 3 3 3 0 DSHCT (NUC185) domain HECT PF00632.25 AET38165.1 - 1.7e-71 241.3 0.0 3.1e-71 240.4 0.0 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DNA_pol_phi PF04931.13 AET38165.1 - 2.4e-05 22.7 3.7 2.4e-05 22.7 3.7 2.4 2 0 0 2 2 2 1 DNA polymerase phi CCDC14 PF15254.6 AET38165.1 - 0.021 13.5 3.0 0.038 12.6 3.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 RL10P_insert PF17777.1 AET38166.1 - 7.8e-19 67.5 0.0 1.2e-18 66.8 0.0 1.3 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 AET38166.1 - 3.1e-16 59.3 0.1 4.6e-16 58.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_S2 PF00318.20 AET38168.1 - 3.6e-66 222.5 1.5 1.4e-65 220.6 0.1 2.3 2 1 0 2 2 2 1 Ribosomal protein S2 DUF4574 PF15141.6 AET38168.1 - 0.95 9.4 2.9 1.8 8.5 0.0 2.8 4 0 0 4 4 4 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 TRAM_LAG1_CLN8 PF03798.16 AET38169.1 - 7.7e-41 140.0 23.1 7.7e-41 140.0 23.1 2.3 2 1 0 2 2 2 1 TLC domain TRAM1 PF08390.11 AET38169.1 - 2e-23 81.8 1.9 5.7e-23 80.4 1.9 1.8 1 0 0 1 1 1 1 TRAM1-like protein VHS PF00790.19 AET38170.1 - 1.7e-28 99.3 2.1 2.4e-28 98.7 0.6 2.0 2 0 0 2 2 2 1 VHS domain SH3_9 PF14604.6 AET38170.1 - 3.9e-14 52.2 0.0 6.5e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 AET38170.1 - 4.1e-14 51.9 0.0 7.1e-14 51.2 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 AET38170.1 - 7.8e-12 44.7 0.0 1.5e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 AET38170.1 - 2.2e-07 31.1 0.4 6.8e-07 29.5 0.4 1.9 1 0 0 1 1 1 1 GAT domain DivIVA PF05103.13 AET38170.1 - 0.0011 19.1 7.6 0.042 13.9 2.9 2.6 2 0 0 2 2 2 2 DivIVA protein YabA PF06156.13 AET38170.1 - 0.35 11.5 4.4 3.9 8.2 0.0 2.9 2 1 0 2 2 2 0 Initiation control protein YabA SUIM_assoc PF16619.5 AET38170.1 - 1.8 8.7 12.2 2.7 8.1 8.3 2.6 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 LMBR1 PF04791.16 AET38170.1 - 5.7 5.7 5.5 3.2 6.5 1.7 1.9 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF3682 PF12446.8 AET38170.1 - 5.9 7.4 7.9 13 6.3 7.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) DUF489 PF04356.12 AET38170.1 - 8.9 6.3 10.2 0.45 10.5 0.8 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF489) F-actin_cap_A PF01267.17 AET38171.1 - 1.1e-69 234.9 0.6 1.2e-69 234.7 0.6 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit DUF5342 PF17277.2 AET38171.1 - 0.02 15.2 0.2 0.049 14.0 0.2 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5342) Mis12 PF05859.12 AET38171.1 - 0.022 14.8 0.2 0.041 13.9 0.0 1.5 2 0 0 2 2 2 0 Mis12 protein NOD2_WH PF17779.1 AET38171.1 - 0.17 12.2 0.6 0.65 10.4 0.1 2.1 2 0 0 2 2 2 0 NOD2 winged helix domain Synaptobrevin PF00957.21 AET38172.1 - 0.2 11.5 2.3 0.53 10.1 2.3 1.8 1 1 0 1 1 1 0 Synaptobrevin Ribosomal_L14e PF01929.17 AET38173.1 - 2e-31 108.3 0.8 3.8e-31 107.4 0.8 1.5 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 AET38173.1 - 3.9e-05 23.4 0.5 7.2e-05 22.6 0.5 1.5 1 0 0 1 1 1 1 KOW motif Ribosomal_S6 PF01250.17 AET38174.1 - 5.1e-24 84.4 0.0 6.5e-24 84.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 Snf7 PF03357.21 AET38175.1 - 6.2e-29 100.8 21.2 7.3e-29 100.6 20.5 1.4 2 0 0 2 2 2 1 Snf7 Ist1 PF03398.14 AET38175.1 - 3.9e-07 30.1 8.2 4.9e-07 29.8 8.2 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Remorin_C PF03763.13 AET38175.1 - 0.36 10.7 11.9 0.77 9.7 11.9 1.6 1 0 0 1 1 1 0 Remorin, C-terminal region Hpt PF01627.23 AET38175.1 - 0.56 10.5 5.5 0.15 12.3 1.6 2.1 2 1 0 2 2 2 0 Hpt domain DUF3958 PF13125.6 AET38175.1 - 1.5 9.1 13.4 0.29 11.3 8.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) Syntaxin-6_N PF09177.11 AET38175.1 - 9.3 6.9 10.6 2.8 8.6 6.1 2.4 2 1 0 3 3 3 0 Syntaxin 6, N-terminal APS_kinase PF01583.20 AET38176.1 - 2.4e-71 238.8 0.0 2.9e-71 238.5 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 AET38176.1 - 2.4e-06 27.8 0.0 5.3e-06 26.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 AET38176.1 - 0.00071 19.1 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 AET38176.1 - 0.007 16.9 0.0 0.01 16.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 AET38176.1 - 0.013 15.2 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.20 AET38176.1 - 0.017 14.3 0.1 0.043 13.0 0.0 1.4 1 1 0 1 1 1 0 G-protein alpha subunit AAA_16 PF13191.6 AET38176.1 - 0.034 14.5 0.0 0.04 14.3 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 AET38176.1 - 0.035 13.4 0.0 0.05 12.9 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin CPT PF07931.12 AET38176.1 - 0.063 13.1 0.1 0.21 11.4 0.1 2.0 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein CbiA PF01656.23 AET38176.1 - 0.067 13.3 0.0 0.074 13.1 0.0 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ABC_tran PF00005.27 AET38176.1 - 0.07 13.7 0.0 0.13 12.7 0.0 1.4 1 1 0 1 1 1 0 ABC transporter Dynamin_M PF01031.20 AET38177.1 - 5.6e-98 327.7 0.2 2.3e-97 325.7 0.0 2.1 3 0 0 3 3 3 1 Dynamin central region Dynamin_N PF00350.23 AET38177.1 - 3.3e-57 193.2 0.1 7.1e-57 192.1 0.1 1.6 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 AET38177.1 - 3.7e-28 97.5 3.3 3.7e-28 97.5 3.3 1.9 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 AET38177.1 - 0.00012 22.1 0.2 0.00062 19.8 0.2 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase HTH_9 PF08221.11 AET38177.1 - 0.16 12.1 0.1 0.59 10.3 0.1 2.0 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain AA_permease_2 PF13520.6 AET38178.1 - 2.8e-84 283.4 46.1 3.3e-84 283.2 46.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AET38178.1 - 6.8e-16 57.9 42.7 1.2e-15 57.1 42.7 1.3 1 1 0 1 1 1 1 Amino acid permease DUF5090 PF17009.5 AET38178.1 - 4.5 7.2 11.1 1.9 8.4 2.5 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF5090) Bromodomain PF00439.25 AET38179.1 - 2e-30 104.7 2.9 1.4e-14 53.9 0.2 2.5 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 AET38179.1 - 2.2e-25 88.9 1.0 4.5e-25 87.9 0.2 2.0 2 0 0 2 2 2 1 BAH domain Lyase_1 PF00206.20 AET38180.1 - 1.2e-22 80.7 0.0 1.9e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 AET38180.1 - 1.7e-18 66.9 0.0 9.4e-18 64.5 0.0 2.3 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus AsiA PF09010.10 AET38180.1 - 0.099 12.8 0.0 0.31 11.2 0.0 1.8 2 0 0 2 2 2 0 Anti-Sigma Factor A Folliculin PF11704.8 AET38181.1 - 3.2e-42 144.5 0.2 5.3e-42 143.8 0.2 1.4 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport Metallophos PF00149.28 AET38182.1 - 2.9e-19 70.4 0.6 1.7e-18 67.9 0.4 2.0 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Pkinase PF00069.25 AET38184.1 - 8.4e-67 225.3 0.2 4.2e-65 219.7 0.2 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38184.1 - 2.1e-48 164.9 0.1 1.5e-47 162.0 0.1 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 AET38184.1 - 6.6e-35 119.5 0.1 1.9e-34 118.0 0.1 1.9 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.17 AET38184.1 - 2.9e-10 40.1 0.2 1.1e-09 38.2 0.1 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 AET38184.1 - 1.2e-08 35.2 0.0 4.5e-08 33.4 0.1 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Pkinase_fungal PF17667.1 AET38184.1 - 0.00027 19.8 0.2 0.00065 18.6 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 AET38184.1 - 0.00042 19.7 0.0 0.0029 17.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like VPS11_C PF12451.8 AET38185.1 - 3.3e-11 43.2 0.2 3.3e-11 43.2 0.2 2.4 2 1 1 3 3 2 1 Vacuolar protein sorting protein 11 C terminal zf-RING_UBOX PF13445.6 AET38185.1 - 3.1e-05 23.9 4.0 9.8e-05 22.3 4.0 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3H2C3 PF17122.5 AET38185.1 - 4.1e-05 23.5 3.9 0.00011 22.2 3.9 1.8 1 1 0 1 1 1 1 Zinc-finger zf-RING_5 PF14634.6 AET38185.1 - 0.00053 19.9 5.7 0.00053 19.9 5.7 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 AET38185.1 - 0.00082 19.5 4.5 0.0063 16.7 4.7 2.5 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 AET38185.1 - 0.0012 18.5 2.6 0.0031 17.1 2.6 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 AET38185.1 - 0.0017 18.7 6.0 0.0017 18.7 6.0 2.0 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 AET38185.1 - 0.0037 17.1 6.5 0.0037 17.1 6.5 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 AET38185.1 - 0.0076 16.1 4.6 0.0076 16.1 4.6 2.4 2 0 0 2 2 1 1 PHD-finger zf-rbx1 PF12678.7 AET38185.1 - 0.011 16.0 4.0 0.034 14.4 4.0 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 AET38185.1 - 0.016 15.3 1.5 0.036 14.1 1.5 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 AET38185.1 - 0.051 13.4 10.5 0.021 14.7 6.9 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 AET38185.1 - 3 7.7 10.7 1.1 9.1 6.8 2.5 2 0 0 2 2 2 0 RING-like zinc finger Prok-RING_4 PF14447.6 AET38185.1 - 8.8 6.3 9.5 0.7 9.8 4.4 1.9 2 0 0 2 2 1 0 Prokaryotic RING finger family 4 ANAPC8 PF04049.13 AET38186.1 - 0.15 12.1 2.3 0.24 11.5 0.2 2.2 2 0 0 2 2 2 0 Anaphase promoting complex subunit 8 / Cdc23 RRS1 PF04939.12 AET38187.1 - 1.7e-59 200.3 3.6 2e-59 200.1 3.6 1.0 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) TCL1_MTCP1 PF01840.17 AET38187.1 - 0.02 14.6 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 TCL1/MTCP1 family Membr_traf_MHD PF10540.9 AET38188.1 - 1.9e-53 180.7 0.0 9.7e-53 178.3 0.0 2.3 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 AET38188.1 - 7.6e-11 42.2 0.4 2.1e-10 40.8 0.0 1.9 2 0 0 2 2 2 1 C2 domain DUF810 PF05664.11 AET38188.1 - 1.3e-05 24.0 0.2 0.00027 19.6 0.1 2.2 2 0 0 2 2 2 1 Plant family of unknown function (DUF810) FlaC_arch PF05377.11 AET38188.1 - 1.6 9.2 4.7 0.88 10.0 0.1 3.1 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Cauli_VI PF01693.16 AET38189.1 - 3.3e-24 84.9 7.2 4.9e-13 49.1 2.3 2.7 2 0 0 2 2 2 2 Caulimovirus viroplasmin RNase_H PF00075.24 AET38189.1 - 3.6e-23 82.3 0.0 1.1e-22 80.7 0.0 1.8 2 0 0 2 2 2 1 RNase H AMP-binding PF00501.28 AET38190.1 - 4.1e-82 276.0 0.2 6.6e-82 275.3 0.2 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AET38190.1 - 0.032 15.2 0.1 0.077 14.0 0.1 1.7 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain DUF1106 PF06523.11 AET38190.1 - 0.051 13.6 0.2 0.14 12.2 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1106) Abhydrolase_1 PF00561.20 AET38191.1 - 1.9e-18 67.1 0.5 7.2e-18 65.1 0.5 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AET38191.1 - 1.5e-13 51.9 0.0 2.1e-13 51.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AET38191.1 - 2.6e-10 40.0 0.0 3.6e-09 36.3 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 AET38191.1 - 0.00084 19.2 0.0 0.0015 18.5 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase zf-MYND PF01753.18 AET38192.1 - 9.4e-06 25.6 23.9 3.1e-05 24.0 23.9 1.9 1 1 0 1 1 1 1 MYND finger Vma12 PF11712.8 AET38193.1 - 5.3e-32 110.8 0.0 6.6e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase Prenyltransf PF01255.19 AET38194.1 - 4.6e-62 209.5 0.2 6.4e-62 209.0 0.2 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase PRESAN PF09687.10 AET38194.1 - 1 10.0 3.8 0.66 10.5 0.1 2.4 3 0 0 3 3 3 0 Plasmodium RESA N-terminal Mito_carr PF00153.27 AET38195.1 - 1.2e-52 175.8 3.9 3.7e-18 65.2 0.3 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein HMD PF03201.16 AET38195.1 - 0.041 14.1 0.1 7.9 6.8 0.0 2.9 2 1 1 3 3 3 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase SRP9-21 PF05486.12 AET38196.1 - 5.5e-16 58.7 0.2 7.2e-15 55.2 0.2 2.2 1 1 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) SPRY PF00622.28 AET38197.1 - 6e-12 45.7 0.1 1.8e-11 44.2 0.1 1.9 1 0 0 1 1 1 1 SPRY domain RRN3 PF05327.11 AET38198.1 - 4e-183 610.0 11.1 4.9e-183 609.7 11.1 1.1 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 AET38198.1 - 5.5e-05 21.6 3.2 9.4e-05 20.8 3.2 1.3 1 0 0 1 1 1 1 Nop14-like family F1F0-ATPsyn_F PF10791.9 AET38198.1 - 0.0072 16.8 0.1 0.019 15.5 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi DUF1539 PF07560.11 AET38198.1 - 0.18 11.9 1.8 0.97 9.5 0.1 2.9 2 2 1 3 3 3 0 Domain of Unknown Function (DUF1539) CDC45 PF02724.14 AET38198.1 - 0.33 9.2 7.3 0.48 8.7 7.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Nop53 PF07767.11 AET38198.1 - 1.5 8.2 7.0 2.3 7.5 7.0 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) SDA1 PF05285.12 AET38198.1 - 1.9 7.8 16.3 3.2 7.1 16.3 1.3 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 AET38198.1 - 4.6 6.5 10.8 8.3 5.6 10.8 1.4 1 0 0 1 1 1 0 BUD22 PGM_PMM_I PF02878.16 AET38199.1 - 7e-33 113.3 0.2 1.1e-32 112.6 0.2 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 AET38199.1 - 2e-25 89.2 0.0 4.1e-25 88.2 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 AET38199.1 - 1.4e-12 48.1 0.0 3.4e-12 46.9 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 AET38199.1 - 4.5e-06 26.8 0.0 1.3e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain CBM_4_9 PF02018.17 AET38199.1 - 0.12 12.6 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain NAD_kinase PF01513.21 AET38199.1 - 0.12 11.5 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 ATP-NAD kinase Fer4_12 PF13353.6 AET38199.1 - 0.19 12.0 0.1 0.6 10.4 0.0 1.8 2 0 0 2 2 2 0 4Fe-4S single cluster domain Ku PF02735.16 AET38200.1 - 3.3e-37 128.2 0.1 5.8e-37 127.4 0.1 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 AET38200.1 - 6.7e-13 48.9 0.7 1.1e-12 48.2 0.7 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain CLASP_N PF12348.8 AET38201.1 - 3e-07 30.2 0.1 8e-07 28.8 0.1 1.7 1 0 0 1 1 1 1 CLASP N terminal APG6_N PF17675.1 AET38201.1 - 0.001 19.6 7.7 0.001 19.6 7.7 2.5 3 0 0 3 3 1 1 Apg6 coiled-coil region DUF641 PF04859.12 AET38201.1 - 0.0013 19.1 3.7 0.0013 19.1 3.7 2.4 3 0 0 3 3 2 1 Plant protein of unknown function (DUF641) Tti2 PF10521.9 AET38201.1 - 0.0016 18.1 0.8 1.1 8.8 0.0 3.6 2 1 0 3 3 3 1 Tti2 family HEAT PF02985.22 AET38201.1 - 0.0033 17.6 0.0 1 9.8 0.0 4.0 3 0 0 3 3 3 1 HEAT repeat PIN_4 PF13638.6 AET38201.1 - 0.006 16.9 1.6 0.018 15.3 1.6 1.8 1 0 0 1 1 1 1 PIN domain DUF1411 PF07199.11 AET38201.1 - 0.0072 16.0 0.3 0.016 14.9 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1411) HAUS-augmin3 PF14932.6 AET38201.1 - 0.017 14.7 7.6 0.053 13.1 7.6 1.8 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 FemAB PF02388.16 AET38201.1 - 0.02 13.8 0.5 0.033 13.1 0.5 1.3 1 0 0 1 1 1 0 FemAB family Leu_zip PF15294.6 AET38201.1 - 0.032 13.7 6.1 0.082 12.4 6.1 1.6 1 0 0 1 1 1 0 Leucine zipper Striatin PF08232.12 AET38201.1 - 0.033 14.8 3.6 0.21 12.2 0.5 2.7 2 0 0 2 2 2 0 Striatin family Golgin_A5 PF09787.9 AET38201.1 - 0.047 13.1 6.0 0.16 11.4 6.0 1.9 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF3450 PF11932.8 AET38201.1 - 0.055 12.8 10.8 0.021 14.2 7.3 2.1 2 0 0 2 2 1 0 Protein of unknown function (DUF3450) Myosin_tail_1 PF01576.19 AET38201.1 - 0.062 11.1 5.8 0.095 10.5 5.8 1.1 1 0 0 1 1 1 0 Myosin tail CENP-F_leu_zip PF10473.9 AET38201.1 - 0.082 12.9 13.2 5.3 7.1 9.0 2.9 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 AET38201.1 - 0.11 11.3 8.7 0.25 10.2 8.7 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein PIN_9 PF18477.1 AET38201.1 - 0.35 11.2 2.0 0.8 10.0 0.4 2.4 2 0 0 2 2 2 0 PIN like domain SOGA PF11365.8 AET38201.1 - 0.41 11.8 8.9 1.7 9.8 6.2 2.7 2 0 0 2 2 2 0 Protein SOGA HAUS2 PF15003.6 AET38201.1 - 0.54 10.0 6.1 2.2 8.0 0.0 2.7 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 2 FAM76 PF16046.5 AET38201.1 - 0.96 8.7 9.4 0.022 14.1 2.0 2.0 3 0 0 3 3 3 0 FAM76 protein Atg14 PF10186.9 AET38201.1 - 1.1 8.2 9.1 0.44 9.6 5.9 1.9 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 IZUMO PF15005.6 AET38201.1 - 1.3 9.5 4.3 16 6.0 3.8 2.9 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated DUF3209 PF11483.8 AET38201.1 - 2 8.9 5.4 5.9 7.4 0.0 3.8 4 1 0 4 4 2 0 Protein of unknown function (DUF3209) OmpH PF03938.14 AET38201.1 - 2.5 8.4 9.9 0.61 10.4 5.5 2.2 2 0 0 2 2 1 0 Outer membrane protein (OmpH-like) HalX PF08663.10 AET38201.1 - 3.3 8.1 4.9 27 5.2 0.4 3.4 2 1 1 3 3 3 0 HalX domain ATG16 PF08614.11 AET38201.1 - 5.6 7.1 19.6 0.025 14.8 6.9 3.0 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) PCRF PF03462.18 AET38201.1 - 8.6 6.2 9.5 0.92 9.3 4.2 2.1 3 0 0 3 3 1 0 PCRF domain TPP_enzyme_N PF02776.18 AET38202.1 - 4.3e-33 114.3 0.1 6.5e-33 113.7 0.1 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 AET38202.1 - 2e-27 95.6 0.0 1.7e-26 92.6 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 AET38202.1 - 6.9e-15 55.1 0.0 1.2e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain AA_permease PF00324.21 AET38203.1 - 2.8e-121 405.4 38.7 3.4e-121 405.2 38.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AET38203.1 - 3.8e-29 101.8 43.9 5.1e-29 101.3 40.7 1.9 1 1 1 2 2 2 2 Amino acid permease MMR_HSR1_C PF08438.10 AET38204.1 - 7.6e-35 119.9 0.0 1.3e-34 119.1 0.0 1.4 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 AET38204.1 - 7.7e-21 74.3 0.0 2e-20 73.0 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AET38204.1 - 5.3e-07 29.3 0.1 8.9e-06 25.3 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 AET38204.1 - 0.00019 21.0 0.0 0.075 12.6 0.0 2.5 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 AET38204.1 - 0.012 15.7 0.2 0.068 13.2 0.1 2.2 2 0 0 2 2 2 0 Dynamin family ABC_tran PF00005.27 AET38204.1 - 0.061 13.8 0.0 0.7 10.4 0.0 2.2 2 0 0 2 2 2 0 ABC transporter ATP_bind_1 PF03029.17 AET38204.1 - 0.1 12.4 0.2 13 5.5 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 AET38204.1 - 0.17 11.8 0.3 5.4 6.9 0.1 2.3 2 0 0 2 2 2 0 RsgA GTPase zf-ZPR1 PF03367.13 AET38205.1 - 5.8e-113 374.0 5.1 8.4e-58 194.7 0.2 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain HypA PF01155.19 AET38205.1 - 0.0046 16.9 3.2 1.8 8.6 0.6 2.6 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Gal4_dimer PF03902.13 AET38205.1 - 0.014 15.5 0.0 4.9 7.4 0.0 2.5 2 0 0 2 2 2 0 Gal4-like dimerisation domain DUF4435 PF14491.6 AET38205.1 - 0.043 13.7 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4435) DnaJ_CXXCXGXG PF00684.19 AET38205.1 - 0.046 14.1 6.1 0.15 12.5 0.1 2.8 2 1 0 2 2 2 0 DnaJ central domain Cytochrom_C_2 PF01322.20 AET38205.1 - 0.35 11.8 2.1 25 5.8 0.3 2.9 3 0 0 3 3 3 0 Cytochrome C' zinc-ribbons_6 PF07191.12 AET38205.1 - 0.57 10.2 3.5 2.9 7.9 0.6 2.6 2 0 0 2 2 2 0 zinc-ribbons CIAPIN1 PF05093.13 AET38205.1 - 0.84 10.2 4.7 0.99 9.9 0.7 2.6 2 0 0 2 2 2 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis OrfB_Zn_ribbon PF07282.11 AET38205.1 - 0.91 9.5 4.9 14 5.6 0.0 3.2 4 0 0 4 4 4 0 Putative transposase DNA-binding domain zinc_ribbon_4 PF13717.6 AET38205.1 - 1.2 9.1 5.0 14 5.7 0.1 3.6 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 AET38205.1 - 9.4 6.1 14.0 19 5.1 0.3 4.0 4 0 0 4 4 4 0 zinc-ribbon domain AATase PF07247.12 AET38206.1 - 2.5e-46 158.3 0.0 8e-46 156.6 0.0 1.6 1 1 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.20 AET38206.1 - 0.0011 17.7 0.0 0.0018 17.0 0.0 1.2 1 0 0 1 1 1 1 Condensation domain Transferase PF02458.15 AET38206.1 - 0.0065 15.2 0.0 0.054 12.1 0.0 1.9 2 0 0 2 2 2 1 Transferase family Tri3 PF07428.11 AET38206.1 - 0.22 10.4 0.0 0.35 9.7 0.0 1.2 1 0 0 1 1 1 0 15-O-acetyltransferase Tri3 LicD PF04991.13 AET38207.1 - 9.1e-13 48.9 0.6 9.1e-13 48.9 0.6 3.5 3 1 0 3 3 3 1 LicD family Ferric_reduct PF01794.19 AET38208.1 - 2e-19 69.9 12.7 2e-19 69.9 12.7 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 AET38208.1 - 0.00077 19.5 0.1 0.0018 18.3 0.1 1.6 1 0 0 1 1 1 1 FAD-binding domain Ytp1 PF10355.9 AET38209.1 - 1.6e-112 375.2 8.3 1.6e-112 375.2 8.3 1.6 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 AET38209.1 - 2e-23 82.2 5.8 2e-23 82.2 5.8 3.1 3 1 1 4 4 4 1 Domain of unknown function (DUF2427) G10 PF01125.17 AET38210.1 - 1.5e-57 193.5 4.0 1.7e-57 193.3 4.0 1.1 1 0 0 1 1 1 1 G10 protein Forkhead PF00250.18 AET38211.1 - 2.7e-33 114.1 0.0 6.3e-33 112.9 0.0 1.7 1 0 0 1 1 1 1 Forkhead domain MAGE_N PF12440.8 AET38211.1 - 1.2 9.9 4.8 5.8 7.7 0.0 3.3 3 0 0 3 3 3 0 Melanoma associated antigen family N terminal zf-C3HC4_2 PF13923.6 AET38212.1 - 2.5e-11 43.2 15.2 4.8e-11 42.3 10.5 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AET38212.1 - 4.5e-09 36.0 15.3 1.4e-08 34.5 10.8 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SAP PF02037.27 AET38212.1 - 1e-08 34.7 0.0 1.9e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 SAP domain zf-RING_UBOX PF13445.6 AET38212.1 - 3e-08 33.6 15.1 8.9e-08 32.0 9.2 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 AET38212.1 - 7.5e-08 32.1 13.2 5.1e-07 29.4 7.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 AET38212.1 - 1.8e-07 30.9 4.9 8.7e-06 25.5 4.4 2.7 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 AET38212.1 - 2.2e-07 30.9 12.2 6.5e-07 29.4 9.7 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 AET38212.1 - 2.3e-06 27.8 15.3 1.3e-05 25.4 9.8 2.6 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 AET38212.1 - 4e-06 26.6 12.1 0.00022 21.0 7.9 2.5 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 AET38212.1 - 4.3e-06 26.6 14.8 1.9e-05 24.5 10.7 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 AET38212.1 - 7.1e-06 26.2 10.7 8.4e-06 26.0 5.9 2.8 2 0 0 2 2 2 1 RING-H2 zinc finger domain RNF220 PF15926.5 AET38212.1 - 0.00012 21.8 2.4 0.00028 20.6 2.4 1.6 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 zf-RING_4 PF14570.6 AET38212.1 - 0.013 15.3 5.4 0.038 13.8 2.0 2.6 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 AET38212.1 - 0.018 15.1 5.8 0.018 15.1 5.8 2.0 2 0 0 2 2 2 0 zinc RING finger of MSL2 U-box PF04564.15 AET38212.1 - 0.03 14.5 0.0 0.9 9.8 0.0 2.7 2 0 0 2 2 2 0 U-box domain Zn-C2H2_12 PF18112.1 AET38212.1 - 0.033 14.7 3.1 0.15 12.6 0.5 2.7 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-ANAPC11 PF12861.7 AET38212.1 - 0.086 12.9 4.4 0.13 12.4 2.8 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf_UBZ PF18439.1 AET38212.1 - 0.11 12.0 0.1 0.39 10.4 0.1 2.0 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger zf-C2HC_2 PF13913.6 AET38212.1 - 0.12 12.4 0.2 0.12 12.4 0.2 3.5 5 0 0 5 5 3 0 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.6 AET38212.1 - 0.16 12.9 0.5 0.16 12.9 0.5 4.1 2 1 1 3 3 2 0 C2H2-type zinc finger zf-Di19 PF05605.12 AET38212.1 - 0.18 12.1 7.3 0.68 10.3 0.1 3.2 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook PF04423.14 AET38212.1 - 2.4 8.0 8.5 13 5.8 0.1 3.9 4 0 0 4 4 4 0 Rad50 zinc hook motif IBR PF01485.21 AET38212.1 - 3.5 7.9 7.4 25 5.2 0.1 2.8 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain UBZ_FAAP20 PF15750.5 AET38212.1 - 3.7 7.6 7.2 8 6.5 0.2 3.2 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger zf-H2C2_2 PF13465.6 AET38212.1 - 4.7 7.8 7.8 0.82 10.2 0.2 3.2 2 1 0 2 2 2 0 Zinc-finger double domain FYVE PF01363.21 AET38212.1 - 8.6 6.6 11.3 8.3 6.6 0.3 2.8 2 1 0 2 2 2 0 FYVE zinc finger ANAPC4_WD40 PF12894.7 AET38213.1 - 1.4e-06 28.5 0.0 0.046 14.0 0.0 3.1 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AET38213.1 - 1.9e-06 28.5 0.2 0.7 10.9 0.1 4.8 4 0 0 4 4 4 2 WD domain, G-beta repeat DUF643 PF04867.12 AET38213.1 - 0.025 15.2 0.5 14 6.3 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF643) Phos_pyr_kin PF08543.12 AET38214.1 - 2.2e-12 46.9 0.0 3e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 AET38214.1 - 0.092 12.0 0.0 0.17 11.1 0.0 1.4 1 1 0 1 1 1 0 pfkB family carbohydrate kinase Lipase_3 PF01764.25 AET38215.1 - 2.5e-05 24.2 0.0 5.1e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 AET38215.1 - 0.014 14.7 0.4 0.38 10.0 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 AET38215.1 - 0.031 14.9 0.2 0.097 13.3 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase family UPF0227 PF05728.12 AET38215.1 - 0.056 13.4 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Pro_isomerase PF00160.21 AET38216.1 - 2.6e-29 102.6 0.1 4e-29 101.9 0.1 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD cobW PF02492.19 AET38217.1 - 4.6e-44 150.1 0.1 7e-44 149.5 0.1 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 AET38217.1 - 0.0015 18.4 0.0 0.0028 17.6 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_29 PF13555.6 AET38217.1 - 0.0027 17.4 0.0 0.0065 16.2 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AET38217.1 - 0.0029 17.5 0.8 0.72 9.7 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 AET38217.1 - 0.0089 16.5 0.0 0.02 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 AET38217.1 - 0.014 15.0 0.0 0.34 10.4 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain ATPase_2 PF01637.18 AET38217.1 - 0.015 15.2 0.1 0.029 14.3 0.1 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 AET38217.1 - 0.034 13.3 0.6 1.3 8.1 0.1 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_18 PF13238.6 AET38217.1 - 0.072 13.6 0.1 0.38 11.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 AET38217.1 - 0.08 13.0 0.0 0.34 11.0 0.0 2.2 1 1 1 2 2 2 0 50S ribosome-binding GTPase DAP3 PF10236.9 AET38217.1 - 0.12 11.6 0.1 0.19 10.8 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_22 PF13401.6 AET38217.1 - 0.12 12.7 0.0 0.36 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 AET38217.1 - 0.15 12.0 0.1 0.3 11.0 0.1 1.5 1 0 0 1 1 1 0 NACHT domain Glyco_transf_22 PF03901.17 AET38218.1 - 1.1e-30 107.2 22.7 1.7e-30 106.6 22.7 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Img2 PF05046.14 AET38219.1 - 1.5e-21 76.5 0.0 2.3e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) WD40 PF00400.32 AET38220.1 - 5.1e-59 194.8 39.5 6.2e-11 42.7 0.2 9.2 9 0 0 9 9 9 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET38220.1 - 8.5e-21 74.1 3.5 1.6e-05 25.1 0.2 5.1 3 1 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 AET38220.1 - 1.6e-08 35.0 0.1 3.3e-08 33.9 0.1 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain eIF2A PF08662.11 AET38220.1 - 3e-08 33.8 1.1 0.00099 19.0 0.0 3.7 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 AET38220.1 - 5.2e-06 25.7 1.5 0.095 11.6 0.5 4.3 2 2 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 AET38220.1 - 0.00017 20.4 9.0 3.1 6.3 0.6 5.6 3 3 3 6 6 6 2 Nucleoporin Nup120/160 WD40_like PF17005.5 AET38220.1 - 0.00076 18.9 0.0 2.7 7.2 0.0 3.6 4 0 0 4 4 4 1 WD40-like domain Nucleoporin_N PF08801.11 AET38220.1 - 0.0018 17.1 1.6 0.17 10.6 0.4 3.3 2 1 0 2 2 2 1 Nup133 N terminal like Nbas_N PF15492.6 AET38220.1 - 0.0053 16.1 2.8 0.72 9.1 0.1 3.2 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 AET38220.1 - 0.0066 16.4 0.1 2.8 8.0 0.0 3.8 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 AET38220.1 - 0.014 14.0 0.1 0.29 9.6 0.1 2.6 2 1 1 3 3 3 0 Cytochrome D1 heme domain PQQ_3 PF13570.6 AET38220.1 - 0.028 14.9 0.1 7.7 7.2 0.0 3.0 2 0 0 2 2 2 0 PQQ-like domain Pkinase PF00069.25 AET38221.1 - 6.5e-66 222.4 0.0 1.4e-65 221.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38221.1 - 8.8e-35 120.2 0.0 1.8e-34 119.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET38221.1 - 0.019 14.3 0.0 0.049 12.9 0.0 1.7 1 0 0 1 1 1 0 Kinase-like Metallophos PF00149.28 AET38222.1 - 1.4e-34 120.4 0.4 4.8e-34 118.6 0.2 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase ubiquitin PF00240.23 AET38223.1 - 1.5e-07 31.1 0.3 1.7e-07 30.8 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 AET38223.1 - 2.4e-05 24.1 0.1 2.6e-05 23.9 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 AET38223.1 - 0.0084 16.5 0.3 0.047 14.2 0.3 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Chorismate_bind PF00425.18 AET38224.1 - 1.9e-65 221.0 0.0 3.1e-65 220.3 0.0 1.4 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 AET38224.1 - 5.1e-32 111.2 0.0 1.1e-31 110.1 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 AET38224.1 - 9.2e-16 58.3 0.1 5.3e-15 55.9 0.0 2.2 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 AET38224.1 - 4.6e-08 33.1 0.0 1.1e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase C26 Glucosamine_iso PF01182.20 AET38225.1 - 9.7e-54 182.6 0.0 3.1e-53 181.0 0.0 1.7 2 0 0 2 2 2 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase BCDHK_Adom3 PF10436.9 AET38226.1 - 9.3e-58 194.6 0.1 1.4e-57 194.0 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 AET38226.1 - 2.8e-11 43.9 0.0 6.9e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Imm42 PF15593.6 AET38226.1 - 0.021 15.3 0.1 0.06 13.8 0.0 1.7 1 1 0 1 1 1 0 Immunity protein 42 HATPase_c_3 PF13589.6 AET38226.1 - 0.025 14.4 0.0 0.1 12.4 0.0 2.0 2 1 1 3 3 3 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Sorb PF02208.16 AET38226.1 - 0.066 13.1 0.2 0.25 11.2 0.2 2.0 1 0 0 1 1 1 0 Sorbin homologous domain CPSase_L_D3 PF02787.19 AET38226.1 - 0.13 12.6 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain LMBR1 PF04791.16 AET38227.1 - 8.1e-31 107.5 19.4 3.4e-30 105.4 19.4 1.8 1 1 0 1 1 1 1 LMBR1-like membrane protein UPF0093 PF03653.13 AET38227.1 - 0.065 13.5 0.3 0.065 13.5 0.3 2.7 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0093) DUF3215 PF11503.8 AET38228.1 - 4.6e-30 103.3 0.2 5.1e-30 103.1 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3215) PI31_Prot_C PF08577.11 AET38229.1 - 8.6e-10 39.7 10.7 8.6e-10 39.7 10.7 1.8 2 0 0 2 2 2 1 PI31 proteasome regulator PAT1 PF09770.9 AET38230.1 - 1.7e-80 271.5 66.6 1e-77 262.3 66.6 3.7 1 1 0 1 1 1 1 Topoisomerase II-associated protein PAT1 JAB PF01398.21 AET38230.1 - 0.35 10.8 4.9 1.4 8.9 0.0 3.3 3 0 0 3 3 3 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF1840 PF08895.11 AET38230.1 - 4.1 7.8 8.2 1.6 9.1 3.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) P34-Arc PF04045.14 AET38231.1 - 4e-92 308.3 0.3 5.1e-92 307.9 0.3 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Ribosom_S12_S23 PF00164.25 AET38232.1 - 1.8e-33 114.5 0.9 2.4e-33 114.1 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 PP2C PF00481.21 AET38233.1 - 4e-31 108.6 0.0 7.9e-27 94.5 0.0 2.7 1 1 1 2 2 2 2 Protein phosphatase 2C Ribosomal_S19 PF00203.21 AET38234.1 - 1.8e-25 88.6 0.0 2.3e-25 88.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 DEAD PF00270.29 AET38235.1 - 8.9e-41 139.6 0.7 1.7e-40 138.6 0.7 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET38235.1 - 2.2e-22 79.5 2.5 1.3e-21 77.0 0.4 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET38235.1 - 1.3e-08 35.0 0.8 2.8e-08 34.0 0.1 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 AET38235.1 - 0.0015 18.6 0.5 0.0048 16.9 0.1 2.2 2 1 0 2 2 2 1 Flavivirus DEAD domain PDCD2_C PF04194.13 AET38235.1 - 0.28 11.2 3.1 0.52 10.4 3.1 1.5 1 0 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain Med12 PF09497.10 AET38236.1 - 4.1e-24 84.7 0.3 1.2e-23 83.2 0.2 1.9 2 0 0 2 2 2 1 Transcription mediator complex subunit Med12 Cation_efflux PF01545.21 AET38237.1 - 0.049 13.4 11.6 0.13 12.0 11.6 1.7 1 1 0 1 1 1 0 Cation efflux family Thioredoxin PF00085.20 AET38239.1 - 1.5e-29 102.0 0.0 1.8e-29 101.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 AET38239.1 - 2.5e-07 31.0 0.3 2.4e-05 24.6 0.1 2.6 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_9 PF14595.6 AET38239.1 - 6.5e-07 29.2 0.0 7.7e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 AET38239.1 - 1.9e-06 28.3 0.2 2.7e-05 24.6 0.1 2.3 2 1 0 2 2 2 1 Thioredoxin-like domain AhpC-TSA PF00578.21 AET38239.1 - 1.4e-05 25.0 0.1 3.7e-05 23.6 0.1 1.7 1 1 1 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 AET38239.1 - 0.0003 20.5 0.0 0.00035 20.3 0.0 1.2 1 0 0 1 1 1 1 Redoxin TraF PF13728.6 AET38239.1 - 0.00038 20.4 0.0 0.00044 20.1 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein OST3_OST6 PF04756.13 AET38239.1 - 0.00058 19.3 0.1 0.00063 19.2 0.1 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 AET38239.1 - 0.0048 17.1 0.1 0.011 16.0 0.1 1.7 1 1 0 1 1 1 1 Thioredoxin-like HyaE PF07449.11 AET38239.1 - 0.014 15.3 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE KaiB PF07689.12 AET38239.1 - 0.029 14.1 0.0 0.047 13.4 0.0 1.3 1 0 0 1 1 1 0 KaiB domain DUF2847 PF11009.8 AET38239.1 - 0.15 12.0 0.1 0.65 9.9 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2847) TMEM223 PF14640.6 AET38240.1 - 0.038 14.2 0.0 0.059 13.5 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 223 UbiA PF01040.18 AET38241.1 - 5.5e-47 160.2 13.0 7.4e-47 159.8 13.0 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family MDD_C PF18376.1 AET38242.1 - 1.9e-66 223.4 0.2 2.5e-66 223.0 0.2 1.1 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 AET38242.1 - 3e-11 43.4 0.8 5.7e-11 42.5 0.8 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain Zn_clus PF00172.18 AET38243.1 - 2.1e-08 34.1 9.0 2.1e-08 34.1 9.0 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Presenilin PF01080.17 AET38243.1 - 1.4 7.6 12.4 2.5 6.8 12.4 1.3 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 AET38243.1 - 2.5 6.5 10.4 4.3 5.8 10.4 1.3 1 0 0 1 1 1 0 Macoilin family Auxin_canalis PF05703.11 AET38243.1 - 3 7.7 4.4 5.5 6.9 4.4 1.5 1 0 0 1 1 1 0 Auxin canalisation WD40 PF00400.32 AET38244.1 - 4.1e-50 166.7 15.9 2.6e-08 34.4 0.0 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 AET38244.1 - 4.3e-30 103.8 13.0 6.6e-30 103.2 13.0 1.3 1 0 0 1 1 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 AET38244.1 - 2.6e-15 56.5 0.0 5e-05 23.5 0.0 5.8 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AET38244.1 - 1.3e-07 30.7 0.4 0.15 10.7 0.0 4.1 2 1 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 AET38244.1 - 7.5e-05 22.2 0.1 0.25 10.7 0.0 4.1 3 1 1 4 4 4 1 WD40-like domain Ge1_WD40 PF16529.5 AET38244.1 - 0.0013 17.8 0.1 1.6 7.6 0.0 3.8 2 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 AET38244.1 - 0.006 15.2 0.6 2.4 6.6 0.3 2.8 2 1 1 3 3 3 2 Cytochrome D1 heme domain UPF0016 PF01169.19 AET38244.1 - 0.2 12.0 2.1 0.42 11.0 2.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein family UPF0016 Ribosomal_60s PF00428.19 AET38244.1 - 0.42 11.2 6.9 1.5 9.5 6.9 1.9 1 0 0 1 1 1 0 60s Acidic ribosomal protein FmiP_Thoc5 PF09766.9 AET38244.1 - 0.58 9.4 8.1 0.88 8.8 8.1 1.1 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 DUF724 PF05266.14 AET38244.1 - 5.5 6.8 6.5 8.9 6.1 6.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Csm1_N PF18504.1 AET38245.1 - 2.3e-27 95.1 8.0 2.3e-27 95.1 8.0 1.7 2 0 0 2 2 2 1 Csm1 N-terminal domain Csm1 PF12539.8 AET38245.1 - 2.4e-23 82.5 0.0 4.4e-23 81.7 0.0 1.4 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 CENP-Q PF13094.6 AET38245.1 - 0.009 16.2 1.9 0.012 15.8 1.9 1.3 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit DUF16 PF01519.16 AET38245.1 - 0.064 13.8 2.1 0.13 12.8 2.1 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 Spc24 PF08286.11 AET38245.1 - 0.069 13.4 4.2 0.099 12.9 3.5 1.7 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 HTH_39 PF14090.6 AET38245.1 - 0.076 12.8 0.0 0.22 11.3 0.1 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain GvpL_GvpF PF06386.11 AET38245.1 - 0.083 12.8 1.6 0.12 12.3 1.6 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF TolA_bind_tri PF16331.5 AET38245.1 - 0.24 11.5 8.8 1.2 9.3 9.4 1.9 2 0 0 2 2 2 0 TolA binding protein trimerisation TMF_DNA_bd PF12329.8 AET38245.1 - 0.38 10.8 10.8 0.067 13.2 7.0 1.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding zf-LYAR PF08790.11 AET38246.1 - 3.2e-13 49.3 5.6 6.7e-13 48.3 5.6 1.6 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger zf-met PF12874.7 AET38246.1 - 0.0026 18.1 2.3 1.5 9.4 0.2 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type UPF0223 PF05256.12 AET38246.1 - 0.044 14.1 0.7 0.18 12.1 0.4 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0223) zf_UBZ PF18439.1 AET38246.1 - 0.077 12.6 1.4 7.5 6.2 0.1 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_4 PF13894.6 AET38246.1 - 0.47 11.4 4.0 16 6.7 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger XPA_N PF01286.18 AET38246.1 - 6.4 6.9 8.5 15 5.7 0.4 2.8 2 1 1 3 3 3 0 XPA protein N-terminal Cofilin_ADF PF00241.20 AET38247.1 - 1e-19 70.5 0.0 2.6e-19 69.2 0.0 1.7 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_1 PF00018.28 AET38247.1 - 5.9e-17 61.0 0.7 1.5e-16 59.7 0.7 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AET38247.1 - 9.5e-15 54.2 0.3 2.3e-14 53.0 0.3 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AET38247.1 - 5.9e-07 29.1 0.0 1.2e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF866 PF05907.13 AET38248.1 - 5.3e-45 153.1 2.4 8.4e-45 152.4 2.4 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) SUV3_C PF12513.8 AET38250.1 - 1.5e-13 50.5 1.8 3.9e-13 49.1 1.8 1.8 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 AET38250.1 - 6.5e-11 42.6 0.0 2.1e-10 40.9 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 AET38250.1 - 0.0043 16.8 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AdoMet_MTase PF07757.13 AET38251.1 - 1.1e-42 144.9 0.4 2e-42 144.0 0.4 1.4 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 AET38251.1 - 0.015 15.3 0.1 0.69 9.9 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 AET38251.1 - 0.12 12.1 0.1 0.38 10.6 0.1 1.8 1 0 0 1 1 1 0 Methyltransferase domain Pkinase PF00069.25 AET38252.1 - 1.1e-73 247.9 0.0 1.3e-73 247.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38252.1 - 1.5e-35 122.7 0.0 2.1e-35 122.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET38252.1 - 0.0023 17.3 0.0 0.0033 16.8 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 AET38252.1 - 0.0041 17.1 0.1 0.035 14.0 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 AET38252.1 - 0.012 14.6 0.0 0.055 12.4 0.0 2.1 1 1 0 1 1 1 0 Haspin like kinase domain ApbA_C PF08546.11 AET38254.1 - 0.00018 21.7 0.0 0.00034 20.8 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal DivIC PF04977.15 AET38254.1 - 0.00044 20.0 6.7 0.027 14.2 1.8 2.4 2 0 0 2 2 2 2 Septum formation initiator CCDC106 PF15794.5 AET38254.1 - 0.076 12.7 1.9 0.093 12.4 0.0 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 YabA PF06156.13 AET38254.1 - 0.12 13.0 5.5 7 7.3 0.4 3.2 2 1 1 3 3 3 0 Initiation control protein YabA Glyco_transf_24 PF18404.1 AET38254.1 - 0.13 11.7 0.6 0.36 10.2 0.6 1.7 1 1 0 1 1 1 0 Glucosyltransferase 24 Ax_dynein_light PF10211.9 AET38254.1 - 0.18 11.8 4.2 0.4 10.6 4.2 1.6 1 0 0 1 1 1 0 Axonemal dynein light chain ZapB PF06005.12 AET38254.1 - 1.5 9.3 7.6 0.48 10.9 2.0 2.4 1 1 1 2 2 2 0 Cell division protein ZapB HALZ PF02183.18 AET38254.1 - 3.3 8.0 8.2 0.48 10.7 0.4 2.7 3 0 0 3 3 3 0 Homeobox associated leucine zipper NAC PF01849.18 AET38255.1 - 4.3e-17 61.8 0.2 8.6e-17 60.9 0.2 1.5 1 0 0 1 1 1 1 NAC domain Glyco_hydro_20b PF02838.15 AET38255.1 - 0.028 15.2 0.1 0.036 14.8 0.1 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 zf-C2H2 PF00096.26 AET38256.1 - 1.8e-08 34.3 6.9 0.002 18.5 2.3 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AET38256.1 - 3.8e-08 33.5 5.5 0.002 18.8 0.1 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 AET38256.1 - 0.0052 17.1 0.9 0.24 11.8 0.0 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_3rep PF18868.1 AET38256.1 - 0.01 16.5 0.5 0.12 13.0 0.1 2.1 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 AET38256.1 - 0.017 15.4 3.0 0.044 14.1 0.2 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 AET38256.1 - 0.029 14.8 7.2 0.39 11.2 0.7 3.3 3 1 0 3 3 3 0 Zinc-finger double domain zf-C2H2_6 PF13912.6 AET38256.1 - 0.03 14.3 4.3 1.8 8.7 0.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 AET38256.1 - 0.036 13.8 4.7 0.97 9.3 0.2 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type Cript PF10235.9 AET38256.1 - 0.16 12.6 1.6 0.62 10.7 1.6 1.9 1 1 0 1 1 1 0 Microtubule-associated protein CRIPT tRNA-synt_1 PF00133.22 AET38258.1 - 6.3e-148 493.7 0.0 4.7e-147 490.8 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AET38258.1 - 1.3e-20 73.9 0.3 7.4e-20 71.5 0.3 2.2 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 AET38258.1 - 6e-17 61.5 0.1 4.3e-10 38.9 0.0 3.4 3 0 0 3 3 3 3 tRNA synthetases class I (M) Asp_protease_2 PF13650.6 AET38258.1 - 0.04 14.6 0.0 0.099 13.3 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease OrfB_Zn_ribbon PF07282.11 AET38258.1 - 0.15 12.0 0.8 0.33 10.9 0.8 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain FLILHELTA PF10306.9 AET38259.1 - 2.2e-19 69.6 0.0 8.1e-19 67.8 0.0 1.9 2 0 0 2 2 2 1 Hypothetical protein FLILHELTA DUF1279 PF06916.13 AET38259.1 - 0.0035 17.9 0.4 0.0071 16.9 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1279) Pkinase PF00069.25 AET38260.1 - 7e-57 192.8 0.0 5.3e-56 189.9 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38260.1 - 1.9e-27 96.2 0.0 7.4e-26 91.0 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AET38260.1 - 0.00073 18.6 0.3 0.0015 17.5 0.3 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Imm7 PF15585.6 AET38260.1 - 0.11 12.8 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 7 RRM_1 PF00076.22 AET38261.1 - 2.7e-53 177.7 0.3 7.2e-16 57.8 0.1 5.4 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AET38261.1 - 1.4e-05 25.1 0.1 0.064 13.4 0.0 4.1 4 0 0 4 4 4 1 RNA recognition motif PHM7_cyt PF14703.6 AET38261.1 - 3e-05 24.3 8.7 1.2 9.3 0.0 5.7 4 3 1 5 5 5 3 Cytosolic domain of 10TM putative phosphate transporter RRM_Rrp7 PF17799.1 AET38261.1 - 0.0003 20.6 0.1 0.37 10.6 0.0 3.2 2 0 0 2 2 2 2 Rrp7 RRM-like N-terminal domain OB_RNB PF08206.11 AET38261.1 - 0.58 9.9 3.6 14 5.4 0.1 3.3 3 0 0 3 3 3 0 Ribonuclease B OB domain CENP-N PF05238.13 AET38262.1 - 4.2e-71 240.5 0.0 8.7e-71 239.4 0.0 1.4 1 1 0 1 1 1 1 Kinetochore protein CHL4 like Vps16_C PF04840.12 AET38263.1 - 1.6e-83 280.5 11.8 2.8e-83 279.6 11.8 1.3 1 0 0 1 1 1 1 Vps16, C-terminal region Vps16_N PF04841.13 AET38263.1 - 1.5e-59 201.8 1.0 2.7e-59 201.0 1.0 1.4 1 0 0 1 1 1 1 Vps16, N-terminal region Skp1_POZ PF03931.15 AET38264.1 - 4.5e-15 55.6 0.3 7e-15 54.9 0.3 1.3 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain BTB PF00651.31 AET38264.1 - 0.052 13.8 0.4 0.11 12.7 0.4 1.6 1 1 0 1 1 1 0 BTB/POZ domain HLH PF00010.26 AET38264.1 - 0.16 12.0 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain CLTH PF10607.9 AET38265.1 - 1.8e-11 44.2 7.9 3.4e-11 43.2 3.4 2.6 2 1 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 AET38265.1 - 0.00089 19.2 3.7 0.0032 17.4 3.7 2.1 1 0 0 1 1 1 1 RING-type zinc-finger Acyltransf_C PF16076.5 AET38265.1 - 0.012 15.7 0.0 0.038 14.1 0.0 1.9 1 0 0 1 1 1 0 Acyltransferase C-terminus DUF4083 PF13314.6 AET38265.1 - 0.12 12.4 0.7 0.24 11.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) IPP-2 PF04979.14 AET38265.1 - 0.49 11.1 3.0 0.87 10.3 3.0 1.3 1 0 0 1 1 1 0 Protein phosphatase inhibitor 2 (IPP-2) zf-RING_2 PF13639.6 AET38265.1 - 0.55 10.6 6.2 0.39 11.1 3.8 2.0 2 0 0 2 2 2 0 Ring finger domain zf-RING_5 PF14634.6 AET38265.1 - 2.5 8.1 8.4 0.23 11.4 2.7 2.2 2 0 0 2 2 2 0 zinc-RING finger domain Sgf11_N PF18519.1 AET38266.1 - 7.4e-22 76.6 3.7 1.1e-21 76.1 3.7 1.3 1 0 0 1 1 1 1 SAGA-associated factor 11 N-terminal domain Sgf11 PF08209.11 AET38266.1 - 4.4e-17 61.3 3.1 6.5e-17 60.8 3.1 1.3 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) zf-CpG_bind_C PF12269.8 AET38266.1 - 0.046 13.5 0.0 0.046 13.5 0.0 1.1 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain Catalase PF00199.19 AET38267.1 - 3.3e-182 605.8 0.2 4.6e-182 605.3 0.2 1.2 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 AET38267.1 - 7.6e-12 45.3 0.2 2.3e-11 43.7 0.1 1.9 2 0 0 2 2 2 1 Catalase-related immune-responsive GST_C PF00043.25 AET38268.1 - 6.7e-13 48.7 0.1 1.1e-12 48.0 0.1 1.3 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 AET38268.1 - 1.3e-06 28.7 0.0 2.5e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 AET38268.1 - 1.7e-06 28.1 0.2 2.4e-06 27.6 0.2 1.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 AET38268.1 - 4.9e-05 23.3 0.3 9.9e-05 22.3 0.3 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 AET38268.1 - 0.034 14.6 0.0 0.081 13.3 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain TPR_12 PF13424.6 AET38268.1 - 0.12 12.7 1.0 0.24 11.7 1.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Anp1 PF03452.14 AET38270.1 - 1e-103 346.3 0.1 1.2e-103 346.1 0.1 1.1 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 AET38270.1 - 0.0093 15.8 0.1 0.019 14.8 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 IlvC PF01450.19 AET38270.1 - 0.047 14.0 0.2 0.13 12.6 0.2 1.7 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain NFACT-R_2 PF18297.1 AET38270.1 - 0.055 13.7 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 NFACT protein RNA binding domain Alk_phosphatase PF00245.20 AET38271.1 - 1.7e-106 356.7 0.1 2e-106 356.4 0.1 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 AET38271.1 - 0.0053 16.2 0.0 0.011 15.1 0.0 1.5 1 0 0 1 1 1 1 Metalloenzyme superfamily Arf PF00025.21 AET38272.1 - 6.2e-46 156.0 0.1 8.6e-46 155.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 AET38272.1 - 1.1e-12 47.8 0.0 1.3e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET38272.1 - 2.4e-12 47.1 0.0 3.6e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 AET38272.1 - 6.6e-12 45.3 0.3 3.6e-06 26.4 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 AET38272.1 - 3.1e-11 43.0 0.0 3.8e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 AET38272.1 - 2.6e-06 27.0 0.1 3.3e-06 26.6 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AET38272.1 - 1.9e-05 24.7 0.0 3e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AET38272.1 - 2.4e-05 24.0 0.0 0.0014 18.2 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 AET38272.1 - 0.015 15.3 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain MeaB PF03308.16 AET38272.1 - 0.068 12.1 0.0 0.22 10.4 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 AET38272.1 - 0.087 13.1 0.0 0.35 11.1 0.0 2.1 1 1 1 2 2 2 0 AAA domain AAA_18 PF13238.6 AET38272.1 - 0.18 12.4 0.1 0.5 10.9 0.1 2.0 1 1 0 1 1 1 0 AAA domain cwf21 PF08312.12 AET38274.1 - 2.6e-11 43.5 7.6 2.6e-11 43.5 7.6 1.6 2 0 0 2 2 2 1 cwf21 domain GCK PF07802.11 AET38274.1 - 0.054 13.9 0.1 0.1 13.0 0.1 1.4 1 0 0 1 1 1 0 GCK domain DUF4404 PF14357.6 AET38274.1 - 0.52 11.0 3.3 0.55 10.9 1.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) Nbl1_Borealin_N PF10444.9 AET38274.1 - 0.79 9.4 4.0 1.4 8.6 0.3 2.3 2 0 0 2 2 2 0 Nbl1 / Borealin N terminal ODC_AZ PF02100.17 AET38275.1 - 6.5e-08 32.6 0.0 8.9e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme MIP PF00230.20 AET38276.1 - 1e-44 152.9 14.1 1.2e-44 152.7 14.1 1.0 1 0 0 1 1 1 1 Major intrinsic protein HXXEE PF13787.6 AET38276.1 - 8.6 7.2 13.0 1.4e+02 3.3 10.1 3.0 1 1 1 2 2 2 0 Protein of unknown function with HXXEE motif Glyco_transf_15 PF01793.16 AET38277.1 - 3.6e-134 447.1 11.2 4.4e-134 446.8 11.2 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase TPR_1 PF00515.28 AET38278.1 - 2.2e-11 43.1 8.5 0.00041 20.0 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 AET38278.1 - 1.3e-08 34.3 4.5 0.014 15.4 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 AET38278.1 - 0.00017 21.7 4.6 0.0011 19.1 4.1 2.3 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 AET38278.1 - 0.00045 20.2 4.4 0.022 14.9 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 AET38278.1 - 0.00048 19.7 0.2 0.13 12.0 0.1 2.7 2 0 0 2 2 2 1 TPR repeat TPR_12 PF13424.6 AET38278.1 - 0.0017 18.6 0.7 0.73 10.2 0.1 3.0 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 AET38278.1 - 0.012 16.0 0.1 0.28 11.7 0.1 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 AET38278.1 - 0.062 14.0 1.1 0.27 12.0 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Pept_S41_N PF18294.1 AET38278.1 - 0.11 12.5 0.1 0.38 10.8 0.1 2.0 1 0 0 1 1 1 0 Peptidase S41 N-terminal domain Fis1_TPR_C PF14853.6 AET38278.1 - 0.37 10.9 2.3 5.3 7.2 0.1 3.0 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat INCENP_ARK-bind PF03941.15 AET38279.1 - 7.4e-16 57.8 1.0 1.8e-15 56.6 1.0 1.7 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region DDE_Tnp_1 PF01609.21 AET38279.1 - 0.037 13.7 0.2 0.098 12.3 0.2 1.7 1 0 0 1 1 1 0 Transposase DDE domain Tox-REase-3 PF15647.6 AET38279.1 - 0.089 13.1 1.4 0.43 10.9 0.1 2.7 2 1 1 3 3 3 0 Restriction endonuclease fold toxin 3 zf-CCCH PF00642.24 AET38281.1 - 6.3e-11 41.9 12.2 2.9e-06 27.0 2.9 3.0 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AET38281.1 - 4.5e-10 39.2 15.9 2.5e-05 24.2 3.7 2.7 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 AET38281.1 - 3.6e-08 33.0 10.4 0.00052 19.7 0.8 2.7 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 AET38281.1 - 2.6e-05 24.9 14.8 0.0061 17.2 0.5 3.5 2 1 1 3 3 3 2 Torus domain SUIM_assoc PF16619.5 AET38281.1 - 3e-05 24.0 0.0 0.00042 20.3 0.0 3.0 2 1 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 zf-CCCH_3 PF15663.5 AET38281.1 - 0.00029 21.0 0.8 0.00029 21.0 0.8 2.2 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 AET38281.1 - 0.0012 19.3 13.5 0.15 12.6 2.1 2.6 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger TFIIA PF03153.13 AET38281.1 - 1.5 8.8 16.6 0.06 13.3 8.7 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Lge1 PF11488.8 AET38282.1 - 1.1e-20 73.5 9.0 2.3e-20 72.5 9.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein LGE1 FAM76 PF16046.5 AET38282.1 - 3.8 6.8 8.3 5.2 6.3 8.3 1.2 1 0 0 1 1 1 0 FAM76 protein adh_short PF00106.25 AET38283.1 - 1.3e-34 119.3 0.1 1.8e-34 118.9 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AET38283.1 - 5.7e-22 78.4 0.0 7.7e-22 78.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AET38283.1 - 8.2e-08 32.4 0.1 1.3e-07 31.7 0.1 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 AET38283.1 - 0.0014 17.8 0.7 0.002 17.3 0.7 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 AET38283.1 - 0.079 12.8 0.0 0.25 11.2 0.0 1.7 1 1 1 2 2 2 0 NAD(P)H-binding Pkinase PF00069.25 AET38284.1 - 4e-74 249.3 0.0 4.6e-74 249.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38284.1 - 1.9e-34 119.2 0.0 2.4e-34 118.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET38284.1 - 1.3e-05 24.6 0.0 2.4e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 AET38284.1 - 0.00046 19.2 0.1 0.0032 16.5 0.1 2.0 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 AET38284.1 - 0.0024 17.8 0.3 0.027 14.4 0.1 2.0 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 AET38284.1 - 0.0056 16.0 0.3 0.037 13.4 0.2 2.2 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 AET38284.1 - 0.12 11.4 0.1 0.19 10.8 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 DUF2401 PF10287.9 AET38285.1 - 2.5e-91 305.3 1.4 2.5e-91 305.3 1.4 2.4 3 0 0 3 3 3 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 AET38285.1 - 1.3e-28 99.2 0.1 3.3e-28 97.9 0.1 1.7 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) GATA PF00320.27 AET38286.1 - 9.3e-16 57.1 4.6 1.9e-15 56.1 4.6 1.6 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 AET38286.1 - 0.16 11.5 0.6 0.3 10.7 0.6 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding XPG_I PF00867.18 AET38287.1 - 5.4e-22 78.0 0.0 1.6e-21 76.4 0.0 1.9 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 AET38287.1 - 6.5e-05 22.5 0.0 0.00017 21.2 0.0 1.6 1 0 0 1 1 1 1 XPG domain containing XPG_N PF00752.17 AET38287.1 - 0.028 14.9 0.0 0.086 13.3 0.0 1.9 1 0 0 1 1 1 0 XPG N-terminal domain PMSR PF01625.21 AET38288.1 - 2.7e-51 173.8 0.4 3.4e-51 173.4 0.4 1.1 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase COX4 PF02936.14 AET38289.1 - 9.7e-10 38.6 0.1 1.2e-09 38.3 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV Pox_A9 PF04835.12 AET38289.1 - 0.0091 16.1 0.4 0.014 15.5 0.4 1.2 1 0 0 1 1 1 1 A9 protein conserved region UCR_6-4kD PF08997.10 AET38289.1 - 0.4 10.6 0.0 0.4 10.6 0.0 1.9 3 0 0 3 3 3 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein SPRY PF00622.28 AET38290.1 - 2.2e-24 85.9 0.1 4.8e-24 84.8 0.1 1.6 1 0 0 1 1 1 1 SPRY domain CLTH PF10607.9 AET38290.1 - 6.1e-12 45.7 2.7 1e-11 44.9 2.7 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 AET38290.1 - 0.017 15.1 0.0 0.061 13.3 0.0 2.0 2 0 0 2 2 2 0 LisH AdoHcyase PF05221.17 AET38291.1 - 2.5e-131 437.3 0.0 1.2e-74 251.2 0.2 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 AET38291.1 - 1.2e-85 285.5 2.1 1.9e-85 284.9 2.1 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 AET38291.1 - 4.4e-08 32.7 0.1 1.2e-07 31.3 0.1 1.7 1 1 1 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 AET38291.1 - 0.00041 19.9 0.1 0.0007 19.2 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 AET38291.1 - 0.0062 16.8 0.1 0.013 15.7 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain Oxidored_nitro PF00148.19 AET38291.1 - 0.032 13.0 0.1 0.19 10.4 0.0 2.1 2 0 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase ELFV_dehydrog PF00208.21 AET38291.1 - 0.078 12.7 0.1 0.16 11.7 0.1 1.5 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase FPL PF09758.9 AET38291.1 - 0.19 11.7 0.0 0.49 10.4 0.0 1.6 1 1 0 1 1 1 0 Uncharacterised conserved protein Tn7_Tnp_TnsA_C PF08721.11 AET38292.1 - 0.00021 21.9 1.8 0.091 13.4 0.1 3.7 4 0 0 4 4 4 2 TnsA endonuclease C terminal Herpes_UL69 PF05459.12 AET38292.1 - 0.056 12.8 1.4 2.1 7.6 0.2 2.3 2 0 0 2 2 2 0 Herpesvirus transcriptional regulator family PuR_N PF09182.10 AET38292.1 - 0.29 11.1 2.1 1.5 8.8 0.1 2.7 3 0 0 3 3 3 0 Bacterial purine repressor, N-terminal DUF1759 PF03564.15 AET38292.1 - 0.41 10.6 5.7 0.85 9.6 0.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1759) SAPS PF04499.15 AET38293.1 - 1.8e-164 548.1 8.9 1.8e-164 548.1 8.9 2.4 2 1 0 2 2 2 1 SIT4 phosphatase-associated protein Imm59 PF15597.6 AET38293.1 - 0.079 13.4 1.6 0.2 12.2 1.6 1.6 1 0 0 1 1 1 0 Immunity protein 59 DUF3246 PF11596.8 AET38293.1 - 2 7.8 11.6 0.064 12.7 4.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) Myc_N PF01056.18 AET38293.1 - 4.5 7.1 11.8 0.1 12.5 1.1 2.8 3 0 0 3 3 3 0 Myc amino-terminal region DnaJ PF00226.31 AET38294.1 - 1.4e-13 50.7 3.3 9.3e-13 48.1 3.3 2.1 2 0 0 2 2 2 1 DnaJ domain Innexin PF00876.18 AET38294.1 - 0.0036 16.7 0.0 0.0062 15.9 0.0 1.3 1 0 0 1 1 1 1 Innexin Adaptin_binding PF10199.9 AET38296.1 - 2.1e-05 25.1 6.0 0.047 14.3 0.2 2.7 2 1 1 3 3 3 2 Alpha and gamma adaptin binding protein p34 Ku_N PF03731.15 AET38296.1 - 0.023 14.4 0.6 0.037 13.8 0.6 1.4 1 1 0 1 1 1 0 Ku70/Ku80 N-terminal alpha/beta domain FERM_N_2 PF18038.1 AET38296.1 - 0.026 15.3 0.0 0.3 11.9 0.0 2.2 2 0 0 2 2 2 0 FERM N-terminal domain DUF1077 PF06417.12 AET38297.1 - 8.5e-43 145.1 3.3 1.1e-42 144.8 3.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) THUMP PF02926.17 AET38298.1 - 1.6e-20 73.7 1.2 7.5e-20 71.5 0.1 2.1 1 1 1 2 2 2 1 THUMP domain DUF2043 PF09740.9 AET38298.1 - 0.063 14.0 0.8 0.22 12.2 0.1 2.2 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2043) MbeB_N PF04837.12 AET38298.1 - 0.074 13.4 1.4 0.26 11.6 1.4 1.9 1 0 0 1 1 1 0 MbeB-like, N-term conserved region Sec15 PF04091.12 AET38299.1 - 2.1e-100 336.2 11.7 2.1e-100 336.2 11.7 2.9 3 0 0 3 3 3 2 Exocyst complex subunit Sec15-like Mito_carr PF00153.27 AET38300.1 - 5.9e-39 131.9 6.8 2.9e-18 65.6 0.2 4.3 2 2 1 3 3 3 3 Mitochondrial carrier protein GARS_A PF01071.19 AET38301.1 - 9.7e-81 270.2 0.0 1.7e-80 269.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain AIRS_C PF02769.22 AET38301.1 - 3.5e-34 118.2 0.0 2.9e-33 115.2 0.0 2.3 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain GARS_N PF02844.15 AET38301.1 - 1.2e-31 109.4 0.0 5.2e-31 107.3 0.0 2.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 AET38301.1 - 2.9e-27 94.8 0.3 7.5e-27 93.4 0.3 1.8 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 AET38301.1 - 1.6e-17 63.9 1.6 1.7e-16 60.7 2.1 2.4 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain ATP-grasp PF02222.22 AET38301.1 - 2.2e-06 27.4 0.0 4.3e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 AET38301.1 - 6.6e-05 23.0 0.1 0.00027 21.0 0.0 2.1 2 1 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.17 AET38301.1 - 0.0021 17.6 0.0 0.0037 16.8 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain RimK PF08443.11 AET38301.1 - 0.025 14.2 0.0 0.094 12.3 0.0 2.0 1 0 0 1 1 1 0 RimK-like ATP-grasp domain ATP-grasp_4 PF13535.6 AET38301.1 - 0.15 11.7 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain GIDA PF01134.22 AET38302.1 - 4.6e-158 526.4 0.0 5.6e-158 526.1 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 AET38302.1 - 4.5e-66 223.0 0.0 7.4e-66 222.3 0.0 1.4 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 AET38302.1 - 2.4e-05 23.9 0.3 3.8e-05 23.2 0.3 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 AET38302.1 - 5.2e-05 22.6 3.8 0.00028 20.2 3.0 2.3 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AET38302.1 - 0.0016 17.6 1.9 0.0016 17.6 1.9 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 AET38302.1 - 0.078 13.5 0.5 0.23 12.1 0.5 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 AET38302.1 - 0.15 11.4 0.0 0.71 9.2 0.0 1.9 2 0 0 2 2 2 0 ThiF family AlaDh_PNT_C PF01262.21 AET38302.1 - 0.16 11.2 0.4 0.31 10.3 0.4 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 AET38302.1 - 2.2 6.9 6.4 6 5.4 1.9 2.5 3 0 0 3 3 3 0 HI0933-like protein CENP-T_C PF15511.6 AET38303.1 - 0.0028 17.7 0.0 0.0053 16.9 0.0 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFB_NFYA PF02045.15 AET38304.1 - 1.6e-26 92.7 9.7 1.6e-26 92.7 9.7 2.1 2 0 0 2 2 2 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Cse1 PF08506.10 AET38305.1 - 1.9e-173 576.5 6.7 1.9e-173 576.5 6.7 2.1 2 0 0 2 2 2 1 Cse1 CAS_CSE1 PF03378.15 AET38305.1 - 1.4e-108 363.2 7.5 2.9e-108 362.2 7.5 1.5 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 AET38305.1 - 8.1e-16 57.7 3.5 3.8e-15 55.6 0.1 3.7 5 0 0 5 5 5 1 Importin-beta N-terminal domain Xpo1 PF08389.12 AET38305.1 - 0.47 10.5 5.5 3.3 7.8 0.2 4.5 2 2 1 3 3 3 0 Exportin 1-like protein Vac14_Fab1_bd PF12755.7 AET38305.1 - 0.98 10.1 3.4 2 9.1 0.1 3.1 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region ANAPC10 PF03256.16 AET38306.1 - 2.7e-42 144.5 0.0 3.2e-42 144.3 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 AET38306.1 - 0.00064 19.8 0.0 0.0014 18.7 0.0 1.6 1 1 0 1 1 1 1 F5/8 type C domain QRPTase_C PF01729.19 AET38307.1 - 6.2e-58 195.3 0.0 7.7e-58 195.0 0.0 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 AET38307.1 - 1.9e-17 63.1 0.0 6.8e-17 61.3 0.0 1.9 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain IBN_N PF03810.19 AET38308.1 - 3.4e-06 26.9 0.0 2.3e-05 24.2 0.0 2.5 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.12 AET38308.1 - 0.45 10.6 12.8 3.2 7.8 0.0 5.7 5 2 2 7 7 7 0 Exportin 1-like protein Ank_3 PF13606.6 AET38309.1 - 1.1e-08 34.6 0.1 0.0049 17.3 0.0 4.0 4 1 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 AET38309.1 - 1.2e-08 35.1 0.0 8.4e-05 22.8 0.0 4.0 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 AET38309.1 - 5.9e-08 32.8 0.3 0.1 13.1 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 AET38309.1 - 2e-07 31.4 0.3 0.00024 21.6 0.2 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 AET38309.1 - 1.5e-06 28.7 0.0 7.2e-06 26.5 0.0 2.0 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) A_deamin PF02137.18 AET38310.1 - 5.8e-27 95.0 0.0 8.3e-27 94.5 0.0 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain APOBEC_N PF08210.11 AET38310.1 - 0.0068 16.3 0.1 0.023 14.6 0.0 1.8 2 0 0 2 2 2 1 APOBEC-like N-terminal domain APOBEC2 PF18772.1 AET38310.1 - 0.05 13.7 1.1 0.35 10.9 0.2 2.5 2 1 0 2 2 2 0 APOBEC2 SNAD4 PF18750.1 AET38310.1 - 0.077 13.1 0.5 0.45 10.6 0.5 2.2 1 1 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 NAD1 PF18778.1 AET38310.1 - 0.11 12.6 1.5 0.99 9.5 0.5 2.7 2 1 0 2 2 2 0 Novel AID APOBEC clade 1 Plus-3 PF03126.18 AET38311.1 - 5.3e-27 94.5 0.0 1.8e-26 92.8 0.0 2.0 1 0 0 1 1 1 1 Plus-3 domain DUF155 PF02582.14 AET38312.1 - 1.2e-53 181.9 0.2 2.5e-53 180.7 0.2 1.6 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Spt20 PF12090.8 AET38312.1 - 0.00068 19.3 6.2 0.0013 18.4 6.2 1.5 1 0 0 1 1 1 1 Spt20 family Roughex PF06020.11 AET38312.1 - 1.1 8.3 4.2 1.7 7.7 4.2 1.2 1 0 0 1 1 1 0 Drosophila roughex protein RAI1 PF08652.11 AET38313.1 - 1.1e-25 89.5 0.3 2.1e-25 88.7 0.3 1.5 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease Brr6_like_C_C PF10104.9 AET38314.1 - 2.4e-41 140.7 1.5 2.7e-41 140.4 1.5 1.0 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain PAPS_reduct PF01507.19 AET38315.1 - 6.8e-42 143.5 0.0 8.3e-42 143.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Med10 PF09748.9 AET38316.1 - 2.6e-39 133.9 0.3 3.3e-39 133.6 0.3 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex NPV_P10 PF05531.12 AET38316.1 - 0.084 13.4 1.2 0.57 10.7 0.5 2.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein PBS_linker_poly PF00427.21 AET38316.1 - 0.085 12.9 0.1 0.085 12.9 0.1 1.5 2 0 0 2 2 2 0 Phycobilisome Linker polypeptide Occludin_ELL PF07303.13 AET38316.1 - 0.09 13.5 0.1 0.62 10.8 0.0 2.1 1 1 1 2 2 2 0 Occludin homology domain ANAPC4_WD40 PF12894.7 AET38317.1 - 6.9e-05 23.1 1.3 0.29 11.5 0.1 4.3 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AET38317.1 - 0.0022 18.8 0.0 12 7.0 0.0 5.1 5 0 0 5 5 5 1 WD domain, G-beta repeat PQQ_3 PF13570.6 AET38317.1 - 0.11 13.0 0.6 25 5.5 0.0 3.2 4 0 0 4 4 4 0 PQQ-like domain ICAP-1_inte_bdg PF10480.9 AET38317.1 - 0.36 10.8 4.7 0.7 9.8 4.7 1.4 1 0 0 1 1 1 0 Beta-1 integrin binding protein DUF4149 PF13664.6 AET38318.1 - 9.1e-18 64.5 2.1 9.1e-18 64.5 2.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) MAS20 PF02064.15 AET38319.1 - 5.1e-36 123.6 0.4 6.5e-36 123.3 0.4 1.1 1 0 0 1 1 1 1 MAS20 protein import receptor SLX9 PF15341.6 AET38320.1 - 1.6e-24 86.8 5.7 2.6e-24 86.1 5.7 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 DUF3818 PF12825.7 AET38321.1 - 1.7e-116 388.9 5.8 1.7e-116 388.9 5.8 1.9 2 0 0 2 2 2 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 AET38321.1 - 1.9e-37 128.2 0.6 4.3e-37 127.0 0.6 1.6 1 0 0 1 1 1 1 PX-associated PX PF00787.24 AET38321.1 - 3.4e-11 43.1 0.3 4.2e-10 39.6 0.1 3.1 2 1 0 2 2 2 1 PX domain Peptidase_C65 PF10275.9 AET38321.1 - 0.012 15.1 0.5 0.042 13.3 0.5 1.9 1 0 0 1 1 1 0 Peptidase C65 Otubain L51_S25_CI-B8 PF05047.16 AET38322.1 - 7.5e-14 51.4 0.1 1.3e-13 50.6 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain IF-2B PF01008.17 AET38323.1 - 9.2e-97 323.6 0.0 1.5e-96 322.9 0.0 1.4 1 0 0 1 1 1 1 Initiation factor 2 subunit family ATP13 PF12921.7 AET38323.1 - 0.039 13.8 0.0 0.12 12.2 0.0 1.9 1 1 0 1 1 1 0 Mitochondrial ATPase expression BCAS2 PF05700.11 AET38325.1 - 1.1e-10 41.5 11.8 2.2e-09 37.3 11.8 2.0 1 1 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Ribosomal_L5_C PF00673.21 AET38326.1 - 9.3e-22 77.0 0.0 1.4e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 AET38326.1 - 5.7e-19 68.2 0.0 1.5e-18 66.9 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L5 HTH_ABP1_N PF18107.1 AET38326.1 - 0.0071 16.0 0.1 0.015 15.0 0.1 1.5 1 0 0 1 1 1 1 Fission yeast centromere protein N-terminal domain Proteasome PF00227.26 AET38327.1 - 3.8e-47 160.3 0.2 4.6e-47 160.0 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Forkhead PF00250.18 AET38328.1 - 9.4e-26 89.9 0.1 9.4e-26 89.9 0.1 2.1 2 0 0 2 2 2 1 Forkhead domain FHA PF00498.26 AET38328.1 - 8.3e-12 45.3 0.1 2e-11 44.0 0.1 1.7 1 0 0 1 1 1 1 FHA domain DUF4407 PF14362.6 AET38328.1 - 1.2 8.4 9.8 2.8 7.2 9.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) COG4 PF08318.12 AET38329.1 - 1.7e-84 283.8 2.9 4e-84 282.6 2.9 1.6 1 0 0 1 1 1 1 COG4 transport protein Vps54_N PF10475.9 AET38329.1 - 0.0038 16.6 7.5 0.013 14.9 7.5 1.9 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Tnp_22_trimer PF17489.2 AET38329.1 - 0.029 14.3 0.1 16 5.6 0.0 3.1 2 0 0 2 2 2 0 L1 transposable element trimerization domain Baculo_PEP_C PF04513.12 AET38329.1 - 0.81 9.7 14.7 1.8 8.6 4.2 3.6 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus HIP1_clath_bdg PF16515.5 AET38329.1 - 4.5 7.9 9.3 4.3 8.0 7.1 2.2 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Pil1 PF13805.6 AET38330.1 - 9.8e-124 412.1 0.2 1.2e-123 411.8 0.2 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 Pkinase PF00069.25 AET38331.1 - 1.3e-15 57.5 0.1 4.7e-15 55.7 0.1 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38331.1 - 3.4e-07 29.8 0.0 4.4e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 AET38331.1 - 0.0018 18.3 0.3 0.0031 17.5 0.3 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family zf-CCCH PF00642.24 AET38332.1 - 9.8e-14 50.9 27.7 0.00039 20.2 0.8 5.5 4 2 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AET38332.1 - 2.3e-12 46.5 36.7 6.5e-06 26.0 2.5 5.6 6 0 0 6 6 6 5 Zinc finger domain Torus PF16131.5 AET38332.1 - 5.7e-11 43.1 20.8 0.0022 18.7 0.3 5.0 1 1 4 5 5 5 3 Torus domain zf-CCCH_3 PF15663.5 AET38332.1 - 1.3e-05 25.4 6.7 1.3e-05 25.4 6.7 2.3 1 1 1 2 2 2 1 Zinc-finger containing family zf-CCCH_4 PF18044.1 AET38332.1 - 0.029 14.2 1.3 0.029 14.2 1.3 5.2 5 3 0 5 5 5 0 CCCH-type zinc finger CBM_19 PF03427.13 AET38332.1 - 0.25 11.4 3.1 2.6 8.1 0.1 2.4 2 0 0 2 2 2 0 Carbohydrate binding domain (family 19) FUN14 PF04930.15 AET38333.1 - 3e-07 30.8 0.8 7.1e-07 29.6 0.8 1.7 1 1 0 1 1 1 1 FUN14 family MadL PF03817.13 AET38333.1 - 0.089 12.8 0.5 0.14 12.2 0.5 1.2 1 0 0 1 1 1 0 Malonate transporter MadL subunit B56 PF01603.20 AET38334.1 - 9.5e-173 574.9 7.9 1.5e-172 574.3 7.9 1.3 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Spo7 PF03907.13 AET38335.1 - 6.7e-72 241.5 8.7 9e-72 241.1 8.7 1.2 1 0 0 1 1 1 1 Spo7-like protein OPT PF03169.15 AET38335.1 - 0.0062 15.2 0.1 0.0091 14.7 0.1 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein MDM10 PF12519.8 AET38336.1 - 3e-146 488.0 15.3 3.4e-146 487.8 15.3 1.0 1 0 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 SMC_N PF02463.19 AET38338.1 - 2e-23 83.0 6.8 8.8e-23 80.9 6.8 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 AET38338.1 - 1.1e-16 62.0 17.6 1.1e-16 62.0 17.6 6.1 3 2 1 4 4 2 1 AAA domain AAA_15 PF13175.6 AET38338.1 - 5.4e-06 26.4 22.2 5.4e-06 26.4 22.2 4.1 3 2 1 4 4 3 1 AAA ATPase domain AAA_29 PF13555.6 AET38338.1 - 3.9e-05 23.3 0.0 8.8e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 AET38338.1 - 0.011 15.6 0.1 0.011 15.6 0.1 3.9 3 2 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Laminin_II PF06009.12 AET38338.1 - 0.024 14.7 1.0 0.024 14.7 1.0 6.5 2 2 3 6 6 6 0 Laminin Domain II NPV_P10 PF05531.12 AET38338.1 - 0.06 13.8 0.5 0.06 13.8 0.5 5.8 5 3 1 6 6 5 0 Nucleopolyhedrovirus P10 protein NACHT PF05729.12 AET38338.1 - 0.081 12.8 0.0 0.27 11.1 0.0 1.9 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 AET38338.1 - 0.15 11.7 0.0 1.2 8.6 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_27 PF13514.6 AET38338.1 - 0.16 11.5 0.0 0.16 11.5 0.0 3.3 3 1 0 3 3 3 0 AAA domain ABC_tran PF00005.27 AET38338.1 - 0.24 11.9 0.1 0.24 11.9 0.1 5.3 3 2 1 4 4 2 0 ABC transporter tRNA-synt_1c PF00749.21 AET38339.1 - 2.6e-104 348.5 0.0 3.5e-104 348.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain DUF775 PF05603.12 AET38340.1 - 8.7e-61 204.9 0.4 1e-60 204.7 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) EF-hand_12 PF17901.1 AET38340.1 - 0.13 12.7 0.9 0.26 11.7 0.2 1.8 2 0 0 2 2 2 0 EF-hand fold domain SIL1 PF16782.5 AET38341.1 - 2.2e-86 289.7 3.8 2.6e-86 289.5 3.8 1.0 1 0 0 1 1 1 1 Nucleotide exchange factor SIL1 Cys_Met_Meta_PP PF01053.20 AET38342.1 - 3.2e-141 470.3 0.1 3.6e-141 470.1 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 AET38342.1 - 9.5e-07 28.3 0.1 1.5e-06 27.7 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Met_gamma_lyase PF06838.11 AET38342.1 - 3.5e-05 22.5 0.0 5.3e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase Aminotran_5 PF00266.19 AET38342.1 - 0.011 14.7 0.1 0.016 14.2 0.1 1.3 1 0 0 1 1 1 0 Aminotransferase class-V Ribosomal_S19 PF00203.21 AET38343.1 - 1.7e-34 117.6 0.5 3.7e-34 116.4 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein S19 FliH PF02108.16 AET38343.1 - 0.12 12.5 0.0 0.14 12.2 0.0 1.1 1 0 0 1 1 1 0 Flagellar assembly protein FliH Sds3 PF08598.11 AET38344.1 - 4.3e-51 174.0 2.2 4.3e-51 174.0 2.2 2.7 2 1 0 2 2 2 1 Sds3-like RRM_1 PF00076.22 AET38345.1 - 7.8e-14 51.2 0.1 1.7e-11 43.8 0.0 3.2 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AET38345.1 - 0.0022 18.1 0.6 0.083 13.0 0.0 3.0 2 1 0 2 2 2 1 RNA recognition motif Nup35_RRM_2 PF14605.6 AET38345.1 - 0.031 14.3 0.0 0.068 13.2 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif SNARE PF05739.19 AET38346.1 - 2.3e-06 27.5 0.2 9.6e-06 25.5 0.2 1.8 2 0 0 2 2 2 1 SNARE domain Exo_endo_phos PF03372.23 AET38348.1 - 5.7e-10 39.1 0.0 1.7e-09 37.5 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HhH-GPD PF00730.25 AET38349.1 - 3.8e-20 72.3 0.0 6e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 AET38349.1 - 0.00046 19.9 0.0 0.00093 19.0 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif IMS_HHH PF11798.8 AET38349.1 - 0.15 12.5 0.0 0.37 11.2 0.0 1.7 1 0 0 1 1 1 0 IMS family HHH motif HEAT PF02985.22 AET38350.1 - 1.7e-41 136.7 20.4 0.0016 18.5 0.0 12.8 13 0 0 13 13 13 10 HEAT repeat HEAT_2 PF13646.6 AET38350.1 - 2.4e-33 114.4 0.7 9e-10 38.8 0.0 7.6 3 3 5 8 8 8 8 HEAT repeats Vac14_Fab1_bd PF12755.7 AET38350.1 - 1.1e-15 57.9 4.5 0.034 14.7 0.0 8.9 3 3 6 9 9 9 4 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 AET38350.1 - 8.1e-12 45.4 8.5 0.33 11.5 0.0 8.6 8 1 1 9 9 9 3 HEAT-like repeat Cnd1 PF12717.7 AET38350.1 - 1.1e-11 45.0 13.9 0.0016 18.5 1.5 6.7 1 1 6 7 7 7 5 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 AET38350.1 - 2.2e-09 36.5 6.8 0.0045 15.6 0.2 3.9 2 1 2 4 4 4 4 Adaptin N terminal region Ecm29 PF13001.7 AET38350.1 - 0.00041 19.2 5.9 0.0019 17.0 0.1 4.1 1 1 1 4 4 4 1 Proteasome stabiliser API5 PF05918.11 AET38350.1 - 0.0083 15.0 9.1 0.019 13.8 0.7 3.5 3 1 1 4 4 4 2 Apoptosis inhibitory protein 5 (API5) M11L PF11099.8 AET38350.1 - 0.036 14.3 3.0 3.5 7.9 0.0 3.6 2 1 1 4 4 4 0 Apoptosis regulator M11L like Arm PF00514.23 AET38350.1 - 0.37 10.9 7.0 7.6 6.7 0.0 5.9 8 1 0 8 8 8 0 Armadillo/beta-catenin-like repeat Pkinase PF00069.25 AET38352.1 - 3.5e-60 203.6 0.0 8.9e-60 202.3 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38352.1 - 3.4e-22 79.0 0.3 7.4e-22 77.9 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 AET38352.1 - 2.8e-06 26.9 0.0 7.9e-06 25.4 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 AET38352.1 - 0.0053 15.6 0.3 0.011 14.5 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 AET38352.1 - 0.0084 15.5 0.0 0.019 14.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AET38352.1 - 0.0092 15.9 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 AET38352.1 - 0.046 13.3 0.1 0.093 12.3 0.1 1.4 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.6 AET38352.1 - 0.35 10.4 1.8 0.41 10.2 0.0 2.0 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 EI24 PF07264.11 AET38353.1 - 0.0016 18.8 17.9 0.012 15.8 17.9 2.0 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) EI24 PF07264.11 AET38354.1 - 0.00012 22.4 14.9 0.00016 22.0 14.9 1.1 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DUF3439 PF11921.8 AET38354.1 - 0.96 9.4 4.7 5.7 6.9 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Piezo_RRas_bdg PF12166.8 AET38354.1 - 7.5 5.7 5.4 1.2 8.3 0.1 1.9 2 0 0 2 2 2 0 Piezo non-specific cation channel, R-Ras-binding domain GSH_synth_ATP PF03917.17 AET38355.1 - 2.1e-125 418.4 0.0 2.4e-125 418.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 AET38355.1 - 2.6e-32 111.3 0.2 4.7e-32 110.5 0.2 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Med15_fungi PF05397.12 AET38356.1 - 2.4e-34 118.0 6.4 2.4e-34 118.0 6.4 9.2 6 3 2 9 9 9 1 Mediator complex subunit 15 KIX_2 PF16987.5 AET38356.1 - 2e-16 59.7 2.2 2e-16 59.7 2.2 5.5 4 1 0 4 4 4 1 KIX domain SUIM_assoc PF16619.5 AET38356.1 - 0.067 13.3 0.0 0.067 13.3 0.0 19.0 6 5 1 7 7 7 0 Unstructured region C-term to UIM in Ataxin3 SNF2_N PF00176.23 AET38357.1 - 4.4e-60 203.2 0.9 4.6e-59 199.9 0.1 2.4 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AET38357.1 - 6e-22 78.1 0.7 1.2e-17 64.3 0.1 3.7 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 AET38357.1 - 3.4e-12 46.7 1.2 1.6e-11 44.5 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AET38357.1 - 1.1e-07 31.8 0.0 4e-07 30.0 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 AET38357.1 - 3.6e-05 23.1 0.2 3.6e-05 23.1 0.2 2.0 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase CUE PF02845.16 AET38357.1 - 0.0036 17.0 0.0 0.013 15.2 0.0 2.1 1 0 0 1 1 1 1 CUE domain ECH_2 PF16113.5 AET38358.1 - 9.9e-87 291.5 0.0 1.4e-86 291.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 AET38358.1 - 2.1e-23 83.0 0.6 2.9e-23 82.5 0.0 1.6 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Topoisom_I_N PF02919.15 AET38358.1 - 0.00057 19.5 1.6 0.0013 18.3 1.6 1.5 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Lipid_DES PF08557.10 AET38359.1 - 3.4e-18 64.8 1.5 5.9e-18 64.1 1.5 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) FA_desaturase PF00487.24 AET38359.1 - 4.7e-18 66.0 12.3 7.2e-18 65.3 12.3 1.3 1 0 0 1 1 1 1 Fatty acid desaturase NDUF_B6 PF09782.9 AET38360.1 - 0.089 12.9 1.3 0.11 12.6 1.3 1.1 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit Pkinase PF00069.25 AET38361.1 - 4.2e-40 137.8 0.1 4.2e-40 137.8 0.1 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38361.1 - 2.2e-27 96.0 0.0 4.2e-27 95.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AET38361.1 - 0.00027 20.0 0.2 0.00027 20.0 0.2 2.3 2 1 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 AET38361.1 - 0.024 14.5 0.0 0.29 11.0 0.0 2.1 1 1 0 2 2 2 0 Phosphotransferase enzyme family ORC2 PF04084.14 AET38362.1 - 1.5e-103 346.3 5.9 1.8e-103 346.0 5.9 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 TFIIS_C PF01096.18 AET38363.1 - 6.2e-22 77.2 2.2 6.2e-22 77.2 2.2 2.8 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 AET38363.1 - 1.4e-11 44.1 4.2 6.8e-11 41.9 1.5 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 AET38363.1 - 0.032 14.2 7.2 0.77 9.8 0.3 3.0 2 1 1 3 3 3 0 Transposase zinc-ribbon domain Terminase_GpA PF05876.12 AET38363.1 - 0.033 12.7 0.4 0.14 10.7 0.4 1.8 1 1 0 1 1 1 0 Phage terminase large subunit (GpA) DZR PF12773.7 AET38363.1 - 0.054 13.5 6.8 0.15 12.1 0.3 2.6 2 1 0 2 2 2 0 Double zinc ribbon IBR PF01485.21 AET38363.1 - 0.078 13.2 0.4 0.078 13.2 0.4 2.8 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain zf-ribbon_3 PF13248.6 AET38363.1 - 0.31 10.5 12.2 0.85 9.1 0.0 4.1 4 0 0 4 4 4 0 zinc-ribbon domain PhnA_Zn_Ribbon PF08274.12 AET38363.1 - 0.48 10.4 7.2 3.4 7.7 0.1 3.2 3 0 0 3 3 3 0 PhnA Zinc-Ribbon TF_Zn_Ribbon PF08271.12 AET38363.1 - 0.58 9.7 9.1 3.7 7.1 1.2 3.0 2 2 0 2 2 2 0 TFIIB zinc-binding Zn_ribbon_SprT PF17283.2 AET38363.1 - 0.65 10.0 7.6 24 4.9 0.1 3.4 3 0 0 3 3 3 0 SprT-like zinc ribbon domain Coprogen_oxidas PF01218.18 AET38364.1 - 5.7e-138 458.6 0.0 6.5e-138 458.4 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase zf-C2H2 PF00096.26 AET38365.1 - 4.7e-05 23.6 21.0 0.0004 20.7 3.6 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AET38365.1 - 0.00021 21.6 13.2 0.0047 17.3 3.7 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 AET38365.1 - 0.12 12.7 0.2 0.12 12.7 0.2 2.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 AET38365.1 - 0.21 12.0 0.2 0.21 12.0 0.2 2.9 2 1 1 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 AET38365.1 - 0.36 11.8 16.4 1.7 9.7 1.9 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 AET38365.1 - 2.3 8.0 7.4 0.11 12.2 1.5 1.9 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-RING_2 PF13639.6 AET38369.1 - 5.1e-09 36.3 11.1 7.5e-09 35.8 11.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 AET38369.1 - 5.6e-08 32.9 11.5 2.3e-07 31.0 11.5 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 AET38369.1 - 9.2e-06 25.6 5.8 2.3e-05 24.3 5.8 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 AET38369.1 - 0.00014 21.6 11.8 0.00022 21.0 11.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AET38369.1 - 0.00058 19.7 12.0 0.0011 18.8 12.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AET38369.1 - 0.055 13.5 9.3 0.1 12.7 9.3 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 AET38369.1 - 0.15 11.9 10.0 0.27 11.1 10.0 1.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AET38369.1 - 0.2 11.6 7.6 0.41 10.6 7.6 1.5 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-P11 PF03854.14 AET38369.1 - 0.33 10.7 10.5 1.1 9.0 9.1 2.1 1 1 1 2 2 2 0 P-11 zinc finger zf-RING_5 PF14634.6 AET38369.1 - 0.44 10.6 9.3 0.66 10.0 9.3 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-Nse PF11789.8 AET38369.1 - 0.6 10.0 5.2 1 9.2 5.2 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_11 PF17123.5 AET38369.1 - 0.61 9.9 10.5 0.068 12.9 6.1 1.7 2 0 0 2 2 2 0 RING-like zinc finger FANCL_C PF11793.8 AET38369.1 - 3.5 7.9 14.5 1.3 9.3 9.1 2.5 2 1 0 2 2 2 0 FANCL C-terminal domain Ribosomal_S10 PF00338.22 AET38370.1 - 1.8e-31 108.2 0.0 9.3e-31 106.0 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein S10p/S20e FtsJ PF01728.19 AET38371.1 - 2e-67 226.7 0.0 2.4e-67 226.4 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase AA_permease PF00324.21 AET38372.1 - 4.7e-125 417.9 37.6 5.9e-125 417.6 37.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AET38372.1 - 4e-34 118.2 33.7 5e-34 117.9 33.7 1.1 1 0 0 1 1 1 1 Amino acid permease COX16 PF14138.6 AET38372.1 - 0.18 12.3 0.0 5 7.7 0.0 2.4 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 AA_permease PF00324.21 AET38373.1 - 6.2e-119 397.7 36.9 8.1e-119 397.3 36.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AET38373.1 - 2e-25 89.5 36.9 2.4e-25 89.3 36.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AET38374.1 - 3.1e-134 448.2 38.1 3.7e-134 447.9 38.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AET38374.1 - 3.7e-38 131.5 38.1 4.3e-38 131.2 38.1 1.0 1 0 0 1 1 1 1 Amino acid permease Pet100 PF09803.9 AET38374.1 - 0.084 13.4 0.1 0.18 12.3 0.1 1.5 1 0 0 1 1 1 0 Pet100 TIM PF00121.18 AET38376.1 - 7.2e-89 297.3 0.0 8.1e-89 297.2 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase Alg14 PF08660.11 AET38377.1 - 4.8e-54 182.9 0.2 6.1e-54 182.6 0.2 1.1 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Maff2 PF12750.7 AET38377.1 - 0.049 13.5 0.3 0.11 12.3 0.3 1.7 1 1 0 1 1 1 0 Maff2 family UQ_con PF00179.26 AET38379.1 - 7e-44 148.9 0.0 9e-44 148.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AET38379.1 - 0.014 15.1 0.0 0.049 13.3 0.0 1.8 1 1 0 1 1 1 0 Prokaryotic E2 family B AMNp_N PF10423.9 AET38379.1 - 0.064 12.9 0.0 0.099 12.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus SLM4 PF16818.5 AET38380.1 - 1e-60 204.4 0.7 1.1e-60 204.2 0.7 1.0 1 0 0 1 1 1 1 Protein SLM4 Dfp1_Him1_M PF08630.10 AET38381.1 - 1.5e-43 148.0 1.7 2.2e-43 147.5 0.0 2.2 3 0 0 3 3 3 1 Dfp1/Him1, central region zf-DBF PF07535.12 AET38381.1 - 7.5e-20 70.8 1.4 1.5e-19 69.8 1.4 1.5 1 0 0 1 1 1 1 DBF zinc finger Pheromone PF08015.11 AET38381.1 - 0.012 16.6 0.2 0.04 15.0 0.2 1.9 1 0 0 1 1 1 0 Fungal mating-type pheromone Fungal_trans_2 PF11951.8 AET38382.1 - 6.1e-11 41.7 2.2 3.6e-10 39.2 2.2 2.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET38382.1 - 2.4e-05 24.3 9.6 2.4e-05 24.3 9.6 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.26 AET38383.1 - 3.2e-11 43.0 8.5 1.5e-05 25.1 0.2 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AET38383.1 - 1.7e-06 28.3 7.1 0.006 17.3 0.1 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AET38383.1 - 7.7e-06 26.1 0.5 7.7e-06 26.1 0.5 2.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 AET38383.1 - 0.0094 15.9 1.8 0.039 14.0 0.1 2.3 2 0 0 2 2 2 1 C2H2-type zinc finger SUIM_assoc PF16619.5 AET38383.1 - 0.027 14.5 0.2 0.11 12.6 0.2 2.0 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 zf-C2H2_8 PF15909.5 AET38383.1 - 0.028 14.7 1.1 0.1 12.9 0.8 2.0 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 AET38383.1 - 0.047 14.0 0.1 0.32 11.4 0.0 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 AET38383.1 - 0.27 11.2 1.3 1.7 8.6 0.0 2.6 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-met PF12874.7 AET38383.1 - 0.29 11.6 3.3 2.1 8.8 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Zn_ribbon_SprT PF17283.2 AET38383.1 - 0.3 11.0 3.1 0.15 12.0 0.8 1.7 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Glyco_hydro81C PF17652.1 AET38384.1 - 5.6e-143 476.4 6.9 7.1e-143 476.1 6.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 AET38384.1 - 2.8e-78 263.3 0.1 3.9e-78 262.9 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain Peptidase_M28 PF04389.17 AET38385.1 - 5.8e-37 127.3 0.0 9.8e-37 126.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 AET38385.1 - 2.2e-05 24.3 0.0 2.7e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 AET38385.1 - 0.00049 19.2 0.0 0.001 18.1 0.0 1.4 1 0 0 1 1 1 1 M42 glutamyl aminopeptidase URO-D PF01208.17 AET38386.1 - 2.9e-125 418.0 0.0 3.3e-125 417.8 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) bVLRF1 PF18826.1 AET38387.1 - 1.5e-59 200.2 0.1 3.5e-59 198.9 0.1 1.7 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 AET38387.1 - 0.021 15.1 0.0 0.046 14.1 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Lysozyme_like PF13702.6 AET38387.1 - 0.054 13.2 0.2 0.11 12.2 0.2 1.5 1 0 0 1 1 1 0 Lysozyme-like DUF2570 PF10828.8 AET38387.1 - 0.44 10.4 7.0 13 5.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) SNF2_N PF00176.23 AET38388.1 - 7.3e-58 195.9 0.1 1.2e-57 195.3 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AET38388.1 - 6.7e-15 55.4 0.0 2.2e-14 53.7 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET38388.1 - 1.9e-12 47.5 0.3 1.2e-11 44.9 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 AET38388.1 - 1.3e-07 31.0 0.1 8.3e-05 21.9 0.1 2.3 2 0 0 2 2 2 2 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 AET38388.1 - 7.4e-05 22.6 0.0 0.00015 21.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 AET38388.1 - 0.017 14.3 0.0 0.034 13.4 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase MFS_1 PF07690.16 AET38389.1 - 4.4e-30 104.8 23.5 4.4e-30 104.8 23.5 2.4 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AET38389.1 - 7.2e-06 25.1 6.2 7.2e-06 25.1 6.2 2.6 2 0 0 2 2 2 2 Sugar (and other) transporter DUF1772 PF08592.11 AET38389.1 - 0.00036 20.8 0.2 0.035 14.4 0.0 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF1772) GFD1 PF17331.2 AET38391.1 - 2.9e-06 27.3 8.7 2.9e-06 27.3 8.7 2.2 2 0 0 2 2 2 1 GFD1 mRNA transport factor COX7a PF02238.15 AET38393.1 - 4.7e-23 81.3 0.3 5.2e-23 81.2 0.3 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII zf-C3HC4_4 PF15227.6 AET38394.1 - 1.8e-07 31.2 4.0 1.8e-07 31.2 4.0 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 AET38394.1 - 7.3e-07 29.0 4.4 7.3e-07 29.0 4.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AET38394.1 - 2.3e-06 27.8 2.8 2.3e-06 27.8 2.8 2.3 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 AET38394.1 - 2.3e-05 24.6 2.6 2.3e-05 24.6 2.6 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 AET38394.1 - 2.5e-05 24.1 2.3 2.5e-05 24.1 2.3 2.5 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 AET38394.1 - 2.6e-05 24.0 2.3 2.6e-05 24.0 2.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AET38394.1 - 2.8e-05 24.1 0.4 7.5e-05 22.7 0.4 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 AET38394.1 - 3.2e-05 23.7 7.1 0.0014 18.4 0.8 2.4 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 AET38394.1 - 7.2e-05 22.6 1.7 7.2e-05 22.6 1.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 AET38394.1 - 8.9e-05 22.5 3.1 0.00031 20.7 0.5 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger DZR PF12773.7 AET38394.1 - 0.013 15.5 8.0 0.74 9.9 0.4 2.5 2 0 0 2 2 2 0 Double zinc ribbon DUF3802 PF12290.8 AET38394.1 - 0.05 14.1 0.1 0.15 12.6 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3802) zinc_ribbon_4 PF13717.6 AET38394.1 - 0.12 12.3 4.6 30 4.6 0.1 3.6 3 0 0 3 3 3 0 zinc-ribbon domain zf-RING_4 PF14570.6 AET38394.1 - 0.17 11.7 12.2 0.062 13.1 3.7 2.6 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 AET38394.1 - 0.29 11.1 6.4 4.4 7.3 0.9 2.7 2 1 1 3 3 3 0 zf-RING of BARD1-type protein HypA PF01155.19 AET38394.1 - 0.36 10.9 8.7 0.26 11.3 0.8 2.5 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA WHEP-TRS PF00458.20 AET38395.1 - 0.024 14.8 1.0 0.13 12.4 0.8 2.2 2 0 0 2 2 2 0 WHEP-TRS domain F-box-like PF12937.7 AET38396.1 - 0.017 15.0 0.1 0.057 13.3 0.1 1.9 1 0 0 1 1 1 0 F-box-like DUF2428 PF10350.9 AET38397.1 - 1.2e-51 175.6 0.3 2.3e-51 174.7 0.3 1.5 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 AET38397.1 - 0.0055 16.9 3.7 0.044 14.0 0.1 4.1 4 0 0 4 4 4 1 HEAT repeat Mg_trans_NIPA PF05653.14 AET38398.1 - 1.1e-108 362.8 17.2 1.4e-108 362.5 17.2 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 AET38398.1 - 2.7e-05 24.4 8.4 2.7e-05 24.4 8.4 3.9 3 1 0 3 3 3 2 EamA-like transporter family Acyl_transf_3 PF01757.22 AET38398.1 - 0.0061 15.7 12.6 0.12 11.5 4.3 2.2 1 1 1 2 2 2 2 Acyltransferase family DUF4131 PF13567.6 AET38398.1 - 0.05 13.3 0.3 6 6.5 0.0 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) DUF4536 PF15055.6 AET38398.1 - 0.072 13.3 0.0 0.27 11.5 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4536) DUF5085 PF16895.5 AET38398.1 - 0.11 12.9 1.3 0.24 11.7 1.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5085) eIF-1a PF01176.19 AET38399.1 - 4e-20 71.4 0.1 5.9e-20 70.8 0.1 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Glyco_transf_20 PF00982.21 AET38400.1 - 8.5e-160 532.5 0.4 4.6e-159 530.1 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 AET38400.1 - 4e-34 117.8 0.0 7.9e-34 116.8 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase TatD_DNase PF01026.21 AET38401.1 - 5.5e-36 124.2 0.0 9.1e-36 123.5 0.0 1.3 1 1 0 1 1 1 1 TatD related DNase SAP30_Sin3_bdg PF13867.6 AET38402.1 - 3.4e-13 49.7 0.1 8.3e-09 35.7 0.0 2.4 2 0 0 2 2 2 2 Sin3 binding region of histone deacetylase complex subunit SAP30 NAGLU_N PF12971.7 AET38402.1 - 0.003 17.3 0.2 0.0062 16.3 0.0 1.6 2 0 0 2 2 2 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Cue1_U7BR PF18499.1 AET38403.1 - 1.2e-21 76.5 3.1 2.3e-21 75.6 3.1 1.5 1 0 0 1 1 1 1 Ubc7p-binding region of Cue1 CUE PF02845.16 AET38403.1 - 4.6e-11 42.2 0.0 1e-10 41.1 0.0 1.7 1 0 0 1 1 1 1 CUE domain WD40 PF00400.32 AET38404.1 - 4.7e-20 71.5 3.1 3.2e-06 27.8 0.0 5.8 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET38404.1 - 4.3e-13 49.4 0.1 2.1e-05 24.7 0.0 4.6 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AET38404.1 - 7.1e-05 22.8 0.1 0.0019 18.1 0.0 2.8 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A HPS3_N PF14761.6 AET38404.1 - 0.2 11.2 0.0 0.48 9.9 0.0 1.6 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 RSN1_7TM PF02714.15 AET38405.1 - 7.5e-81 271.4 26.4 7.5e-81 271.4 26.4 1.9 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 AET38405.1 - 2.1e-39 134.8 3.5 2.1e-39 134.8 3.5 2.7 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 AET38405.1 - 1.5e-32 113.2 0.1 2.3e-32 112.6 0.1 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 AET38405.1 - 2.4e-26 91.7 0.0 9.9e-26 89.7 0.0 2.0 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter DUF4618 PF15397.6 AET38405.1 - 0.12 11.8 0.1 0.18 11.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Pyrophosphatase PF00719.19 AET38406.1 - 8.6e-52 175.2 0.0 1.1e-51 174.8 0.0 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase RRM_1 PF00076.22 AET38407.1 - 1.6e-35 120.7 2.9 1.8e-12 46.9 0.1 4.4 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AET38407.1 - 2.5e-34 117.0 1.7 1e-27 95.8 0.3 4.6 4 1 0 4 4 4 2 Occluded RNA-recognition motif Lsm_interact PF05391.11 AET38407.1 - 2e-06 27.1 1.4 5.6e-06 25.7 1.4 1.8 1 0 0 1 1 1 1 Lsm interaction motif Nup35_RRM_2 PF14605.6 AET38407.1 - 0.00033 20.6 0.1 0.39 10.7 0.0 2.5 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 AET38407.1 - 0.00085 18.9 0.5 0.007 16.0 0.0 2.8 3 1 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 AET38407.1 - 0.0038 17.5 2.2 0.11 12.7 0.0 3.2 3 1 0 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 AET38407.1 - 0.011 15.8 0.0 0.043 13.9 0.0 2.0 1 1 0 1 1 1 0 RNA recognition motif SGT1 PF07093.11 AET38407.1 - 0.017 13.6 0.0 0.029 12.8 0.0 1.3 1 0 0 1 1 1 0 SGT1 protein G-patch PF01585.23 AET38408.1 - 0.0094 15.8 1.6 0.033 14.1 1.6 1.9 1 1 0 1 1 1 1 G-patch domain PXA PF02194.15 AET38409.1 - 2.1e-33 115.8 0.8 2.1e-33 115.8 0.8 2.4 2 1 0 2 2 2 1 PXA domain Nexin_C PF08628.12 AET38409.1 - 2.6e-21 76.3 2.3 4.6e-21 75.5 0.1 2.5 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.24 AET38409.1 - 3e-12 46.5 4.6 1.5e-11 44.2 1.9 2.8 2 0 0 2 2 2 1 PX domain RGS PF00615.19 AET38409.1 - 1.1e-06 29.0 2.1 2.1e-06 28.0 0.7 2.4 2 0 0 2 2 2 1 Regulator of G protein signaling domain DUF724 PF05266.14 AET38409.1 - 0.23 11.2 3.6 0.37 10.6 1.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF16 PF01519.16 AET38409.1 - 1.6 9.2 8.4 3.9 8.0 2.2 3.5 3 0 0 3 3 3 0 Protein of unknown function DUF16 RRN9 PF10680.9 AET38410.1 - 6.6e-16 58.4 1.0 2.5e-15 56.5 0.6 2.1 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor NOA36 PF06524.12 AET38410.1 - 0.012 14.9 15.8 0.018 14.3 15.8 1.2 1 0 0 1 1 1 0 NOA36 protein SDA1 PF05285.12 AET38410.1 - 0.028 13.9 13.4 0.052 13.0 13.4 1.4 1 0 0 1 1 1 0 SDA1 Cwf_Cwc_15 PF04889.12 AET38410.1 - 0.046 13.4 17.3 0.097 12.4 17.3 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2457 PF10446.9 AET38410.1 - 0.16 11.1 20.5 0.26 10.4 20.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF3295 PF11702.8 AET38410.1 - 0.57 9.5 8.6 0.97 8.7 8.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) RNA_pol_3_Rpc31 PF11705.8 AET38410.1 - 0.67 10.2 18.5 0.27 11.5 15.9 1.7 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 CDC45 PF02724.14 AET38410.1 - 2.6 6.2 14.4 3.8 5.7 14.4 1.2 1 0 0 1 1 1 0 CDC45-like protein SRP19 PF01922.17 AET38411.1 - 7.9e-32 110.1 0.0 1.4e-31 109.3 0.0 1.4 1 0 0 1 1 1 1 SRP19 protein Pribosyltran PF00156.27 AET38412.1 - 1.1e-18 67.3 0.5 1.8e-18 66.5 0.2 1.5 2 0 0 2 2 2 1 Phosphoribosyl transferase domain zf-C3HC PF07967.13 AET38413.1 - 2.5e-09 37.3 3.3 1.1e-07 31.9 1.0 3.0 2 1 1 3 3 3 2 C3HC zinc finger-like SUN PF03856.13 AET38414.1 - 8.2e-83 277.6 15.2 9.3e-83 277.4 15.2 1.0 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) Integrin_b_cyt PF08725.11 AET38414.1 - 2.6 7.8 5.8 1.7 8.4 0.6 2.3 2 0 0 2 2 2 0 Integrin beta cytoplasmic domain CPBP PF02517.16 AET38415.1 - 2.7e-14 53.3 7.0 2.7e-14 53.3 7.0 2.6 3 0 0 3 3 3 1 CPBP intramembrane metalloprotease DUF4029 PF13221.6 AET38415.1 - 1.3 9.7 4.7 0.65 10.7 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4029) Zds_C PF08632.10 AET38416.1 - 1.6e-29 101.4 2.3 3.2e-29 100.4 2.3 1.5 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term DUF1892 PF08987.10 AET38417.1 - 6.5e-44 148.6 1.8 8.2e-44 148.3 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1892) PP1_inhibitor PF05361.12 AET38417.1 - 0.11 12.5 0.1 0.22 11.5 0.1 1.5 1 1 1 2 2 2 0 PKC-activated protein phosphatase-1 inhibitor Cyt-b5 PF00173.28 AET38418.1 - 2.5e-14 53.2 0.7 1.2e-13 51.0 0.0 2.1 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 AET38418.1 - 1.8e-12 47.8 12.3 1.8e-12 47.8 12.3 1.8 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.13 AET38418.1 - 0.0033 17.6 0.2 0.0073 16.5 0.2 1.5 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region ABC_tran PF00005.27 AET38419.1 - 8.3e-45 152.7 4.9 1e-22 81.1 0.0 3.4 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 AET38419.1 - 2.1e-19 69.3 9.3 2.1e-19 69.3 9.3 3.3 4 0 0 4 4 2 1 ABC transporter AAA_21 PF13304.6 AET38419.1 - 3.3e-16 60.0 16.7 4.6e-05 23.4 0.0 5.4 3 2 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AET38419.1 - 3.2e-11 43.1 0.0 0.00018 21.1 0.1 3.5 3 0 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 AET38419.1 - 1.3e-06 28.8 0.1 0.052 13.8 0.0 3.1 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.6 AET38419.1 - 2.3e-06 27.9 1.0 0.15 12.3 0.1 3.6 3 1 0 3 3 3 2 AAA domain AAA_23 PF13476.6 AET38419.1 - 2.6e-06 28.1 32.5 0.25 11.8 0.0 5.3 5 0 0 5 5 5 3 AAA domain AAA_18 PF13238.6 AET38419.1 - 3e-06 27.8 5.4 0.075 13.6 0.1 4.3 5 0 0 5 5 3 2 AAA domain AAA_14 PF13173.6 AET38419.1 - 7.3e-06 26.1 0.1 0.14 12.2 0.1 3.3 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 AET38419.1 - 7.4e-06 26.4 1.9 0.12 12.7 0.1 3.1 3 1 0 3 3 3 2 AAA ATPase domain AAA PF00004.29 AET38419.1 - 1.1e-05 25.8 1.1 0.14 12.5 0.0 4.2 5 1 0 5 5 3 2 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 AET38419.1 - 2e-05 24.5 28.7 0.013 15.2 0.0 4.5 3 1 1 4 4 4 2 AAA ATPase domain NACHT PF05729.12 AET38419.1 - 2.1e-05 24.5 0.2 0.1 12.5 0.1 2.6 2 0 0 2 2 2 2 NACHT domain AAA_29 PF13555.6 AET38419.1 - 9.2e-05 22.1 6.4 0.097 12.4 0.0 3.1 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_24 PF13479.6 AET38419.1 - 0.00012 21.9 0.0 0.39 10.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain ATP-synt_ab PF00006.25 AET38419.1 - 0.00015 21.5 0.0 0.039 13.6 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain RsgA_GTPase PF03193.16 AET38419.1 - 0.00016 21.6 5.3 0.046 13.6 0.2 3.2 3 1 1 4 4 3 2 RsgA GTPase PduV-EutP PF10662.9 AET38419.1 - 0.00027 20.7 0.3 0.45 10.2 0.1 2.6 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 AET38419.1 - 0.00028 21.2 0.6 0.6 10.5 0.0 3.0 3 0 0 3 3 2 1 RNA helicase AAA_33 PF13671.6 AET38419.1 - 0.00034 20.8 2.5 0.17 12.0 0.0 3.3 3 1 0 3 3 3 1 AAA domain MMR_HSR1 PF01926.23 AET38419.1 - 0.00037 20.6 4.0 0.18 11.9 0.2 3.8 4 1 1 5 5 3 1 50S ribosome-binding GTPase NB-ARC PF00931.22 AET38419.1 - 0.00063 19.0 0.1 0.76 8.9 0.0 2.7 2 0 0 2 2 2 2 NB-ARC domain AAA_30 PF13604.6 AET38419.1 - 0.00071 19.4 0.0 4.7 6.9 0.0 4.5 4 1 0 4 4 4 0 AAA domain Roc PF08477.13 AET38419.1 - 0.0011 19.2 0.9 1.7 8.8 0.0 2.9 3 0 0 3 3 2 2 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.15 AET38419.1 - 0.0016 18.4 0.0 0.76 9.7 0.0 2.8 2 0 0 2 2 2 1 NTPase Rad17 PF03215.15 AET38419.1 - 0.0026 17.7 0.0 0.85 9.5 0.0 2.8 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_7 PF12775.7 AET38419.1 - 0.0036 16.8 0.0 1.3 8.5 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region DUF815 PF05673.13 AET38419.1 - 0.0044 16.2 0.1 1.6 7.9 0.1 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 AET38419.1 - 0.0051 16.8 0.1 5.8 6.9 0.0 2.8 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 AET38419.1 - 0.0052 16.8 0.0 0.78 9.7 0.0 2.8 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE MeaB PF03308.16 AET38419.1 - 0.0054 15.7 0.1 0.9 8.5 0.0 2.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 AET38419.1 - 0.0082 15.4 0.0 2.7 7.2 0.0 2.9 2 0 0 2 2 2 1 Zeta toxin FeoB_N PF02421.18 AET38419.1 - 0.011 15.3 0.0 6.2 6.3 0.0 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B MobB PF03205.14 AET38419.1 - 0.012 15.5 0.1 0.56 10.1 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Pox_A32 PF04665.12 AET38419.1 - 0.017 14.6 0.3 0.85 9.0 0.0 2.7 3 0 0 3 3 2 0 Poxvirus A32 protein SRP54 PF00448.22 AET38419.1 - 0.027 14.1 0.2 2.8 7.5 0.1 2.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_25 PF13481.6 AET38419.1 - 0.031 13.8 0.0 1.9 8.0 0.0 2.8 2 0 0 2 2 2 0 AAA domain DUF1409 PF07197.12 AET38419.1 - 0.04 13.8 0.0 0.15 12.0 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1409) Septin PF00735.18 AET38419.1 - 0.042 13.1 8.0 1.3 8.3 0.1 3.4 3 1 0 3 3 3 0 Septin Ras PF00071.22 AET38419.1 - 0.043 13.4 2.4 15 5.2 0.0 3.6 3 0 0 3 3 3 0 Ras family cobW PF02492.19 AET38419.1 - 0.045 13.3 0.4 8.2 6.0 0.1 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SbcCD_C PF13558.6 AET38419.1 - 0.047 13.9 0.1 29 5.0 0.1 3.3 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Viral_helicase1 PF01443.18 AET38419.1 - 0.085 12.6 0.0 3.1 7.5 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_17 PF13207.6 AET38419.1 - 0.93 9.9 6.3 21 5.5 0.1 3.8 3 1 0 3 3 3 0 AAA domain T3SSipB PF16535.5 AET38419.1 - 1.6 9.2 9.8 3.8 8.0 1.7 3.4 3 0 0 3 3 3 0 Type III cell invasion protein SipB Dynamin_N PF00350.23 AET38419.1 - 2.3 8.3 14.7 0.063 13.3 1.5 3.7 3 1 1 4 4 4 0 Dynamin family DUF87 PF01935.17 AET38419.1 - 2.6 8.1 0.0 2.6 8.1 0.0 5.5 5 2 1 6 6 5 0 Helicase HerA, central domain LAMTOR PF15454.6 AET38419.1 - 5.4 7.7 10.7 2.9 8.6 2.6 2.8 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator RNB PF00773.19 AET38420.1 - 2.2e-99 332.9 0.8 3.6e-99 332.2 0.8 1.4 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.3 AET38420.1 - 1.2e-68 229.5 0.1 2.8e-68 228.3 0.1 1.7 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 AET38420.1 - 3.3e-27 94.3 0.4 1.1e-26 92.6 0.4 1.9 1 0 0 1 1 1 1 S1 domain OB_Dis3 PF17849.1 AET38420.1 - 2e-17 63.0 0.0 5e-17 61.7 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 AET38420.1 - 1.8e-16 60.6 0.9 4.8e-16 59.2 0.9 1.7 1 0 0 1 1 1 1 PIN domain CSD2 PF17876.1 AET38420.1 - 4.3e-06 26.8 0.0 0.0088 16.2 0.0 3.0 2 0 0 2 2 2 2 Cold shock domain Dis3l2_C_term PF17877.1 AET38420.1 - 0.048 14.0 0.5 0.13 12.6 0.0 2.0 2 0 0 2 2 2 0 DIS3-like exonuclease 2 C terminal PIN_12 PF16289.5 AET38420.1 - 0.048 14.1 0.1 0.18 12.3 0.1 2.0 1 0 0 1 1 1 0 PIN domain OB_RNB PF08206.11 AET38420.1 - 0.13 12.0 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 Ribonuclease B OB domain Acid_phosphat_B PF03767.14 AET38420.1 - 0.14 11.8 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) AA_permease PF00324.21 AET38421.1 - 1.3e-115 386.7 39.0 1.6e-115 386.5 39.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AET38421.1 - 2.3e-32 112.4 38.1 2.8e-32 112.1 38.1 1.1 1 0 0 1 1 1 1 Amino acid permease UCH PF00443.29 AET38422.1 - 8.7e-50 169.6 0.1 1.2e-49 169.1 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AET38422.1 - 2.1e-11 44.0 3.4 2.2e-09 37.3 3.4 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 AET38422.1 - 0.0025 17.5 0.0 0.012 15.4 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin family RNase_H2-Ydr279 PF09468.10 AET38422.1 - 0.033 14.4 0.0 0.65 10.2 0.0 2.5 2 1 0 2 2 2 0 Ydr279p protein family (RNase H2 complex component) wHTH domain DUF1690 PF07956.11 AET38423.1 - 1.7e-36 125.7 5.1 1.9e-36 125.5 5.1 1.0 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) Trimer_CC PF08954.11 AET38423.1 - 0.015 14.9 0.3 0.047 13.2 0.1 1.9 2 0 0 2 2 2 0 Trimerisation motif DUF2564 PF10819.8 AET38423.1 - 0.21 12.0 4.2 0.71 10.3 0.4 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2564) SUR7 PF06687.12 AET38424.1 - 5.5e-18 65.4 11.3 7.9e-18 64.9 11.3 1.2 1 0 0 1 1 1 1 SUR7/PalI family FA_desaturase PF00487.24 AET38424.1 - 0.0023 17.8 1.9 0.0023 17.8 1.9 1.8 2 0 0 2 2 2 1 Fatty acid desaturase DuoxA PF10204.9 AET38424.1 - 0.041 12.9 1.1 0.072 12.1 1.1 1.3 1 0 0 1 1 1 0 Dual oxidase maturation factor ABC2_membrane_3 PF12698.7 AET38424.1 - 5.7 6.0 7.9 0.12 11.4 0.8 1.7 2 0 0 2 2 2 0 ABC-2 family transporter protein Clat_adaptor_s PF01217.20 AET38426.1 - 1.5e-53 180.5 1.1 1.8e-53 180.3 1.1 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TP_methylase PF00590.20 AET38427.1 - 2.2e-29 102.9 0.0 3.1e-29 102.5 0.0 1.2 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF4434 PF14488.6 AET38427.1 - 0.008 16.2 0.1 0.043 13.8 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4434) Gemini_AC4_5 PF04807.12 AET38428.1 - 1 9.1 3.0 7 6.4 0.2 2.7 2 0 0 2 2 2 0 Geminivirus AC4/5 conserved region DUF733 PF05306.11 AET38429.1 - 0.019 15.3 0.3 0.074 13.4 0.3 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF733) CENP-H PF05837.12 AET38429.1 - 0.026 14.9 1.6 0.97 9.9 0.3 2.7 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Mpv17_PMP22 PF04117.12 AET38430.1 - 1.2e-22 79.8 4.2 2.1e-22 79.1 4.2 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family ABC1 PF03109.16 AET38431.1 - 4.6e-32 110.7 0.0 1e-31 109.5 0.0 1.6 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 AET38431.1 - 0.0018 17.9 0.0 0.0056 16.3 0.0 1.8 1 0 0 1 1 1 1 RIO1 family PSII_Pbs27 PF13326.6 AET38432.1 - 0.025 14.9 0.2 0.043 14.1 0.2 1.3 1 0 0 1 1 1 0 Photosystem II Pbs27 V_ATPase_I PF01496.19 AET38432.1 - 0.025 12.5 1.3 0.026 12.5 1.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ycf1 PF05758.12 AET38432.1 - 0.029 12.3 2.7 0.036 12.0 2.7 1.0 1 0 0 1 1 1 0 Ycf1 CC2-LZ PF16516.5 AET38432.1 - 0.043 14.2 11.4 0.074 13.4 8.4 2.0 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator ZapB PF06005.12 AET38432.1 - 0.049 14.1 17.3 0.42 11.1 12.0 2.9 1 1 1 2 2 2 0 Cell division protein ZapB Baculo_PEP_C PF04513.12 AET38432.1 - 0.072 13.1 2.6 0.13 12.3 2.6 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cas_DxTHG PF09455.10 AET38432.1 - 0.1 12.1 2.4 0.14 11.8 2.4 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family Golgin_A5 PF09787.9 AET38432.1 - 0.19 11.2 11.4 0.27 10.7 11.4 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 Fzo_mitofusin PF04799.13 AET38432.1 - 0.22 11.1 3.6 0.48 10.0 3.6 1.6 1 0 0 1 1 1 0 fzo-like conserved region MamL-1 PF09596.10 AET38432.1 - 0.42 10.9 3.0 3.6 7.9 1.2 2.4 2 0 0 2 2 2 0 MamL-1 domain DUF1635 PF07795.11 AET38432.1 - 0.61 9.9 7.5 0.79 9.5 7.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1635) DUF4407 PF14362.6 AET38432.1 - 0.85 8.9 3.8 1.3 8.3 3.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Prominin PF05478.11 AET38432.1 - 1.1 7.1 4.8 1.3 6.8 4.8 1.1 1 0 0 1 1 1 0 Prominin ACCA PF03255.14 AET38432.1 - 2 8.3 5.9 2.1 8.2 4.2 1.8 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit LMBR1 PF04791.16 AET38432.1 - 3.3 6.5 4.4 4.3 6.1 4.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Csm1_N PF18504.1 AET38432.1 - 3.5 8.0 13.4 12 6.3 0.2 3.4 2 1 1 3 3 3 0 Csm1 N-terminal domain DUF1664 PF07889.12 AET38432.1 - 6.9 6.7 8.0 8.6 6.4 5.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) HalX PF08663.10 AET38432.1 - 8.4 6.8 10.6 0.87 10.0 5.9 1.8 2 0 0 2 2 2 0 HalX domain OCD_Mu_crystall PF02423.15 AET38433.1 - 1.2e-09 37.5 0.0 1.9e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 AET38433.1 - 0.05 13.7 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Zn_clus PF00172.18 AET38434.1 - 1.4e-08 34.7 8.0 3.4e-08 33.5 8.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 AET38434.1 - 1.7e-08 33.9 3.0 3.3e-08 32.9 3.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ferric_reduct PF01794.19 AET38435.1 - 2.8e-18 66.2 12.6 6.9e-18 65.0 12.6 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 AET38435.1 - 2e-12 47.1 0.0 4.2e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 AET38435.1 - 2.2e-09 37.6 0.0 4.2e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain TraL PF07178.11 AET38435.1 - 0.045 14.2 0.8 1.2 9.7 0.1 2.9 2 0 0 2 2 2 0 TraL protein CrgA PF06781.12 AET38435.1 - 1.8 8.7 5.9 48 4.1 4.8 2.6 2 0 0 2 2 2 0 Cell division protein CrgA Peptidase_M28 PF04389.17 AET38436.1 - 5.4e-40 137.2 0.0 7.6e-40 136.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 ABC2_membrane PF01061.24 AET38437.1 - 9.7e-37 126.4 17.4 9.7e-37 126.4 17.4 1.8 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 AET38437.1 - 5.3e-26 91.8 0.0 9.6e-26 90.9 0.0 1.5 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 AET38437.1 - 0.00027 20.9 0.3 0.00052 20.0 0.3 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 AET38437.1 - 0.13 12.1 0.2 0.31 10.8 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_pol_Rpc34 PF05158.12 AET38438.1 - 8.5e-115 383.7 1.1 9.8e-115 383.5 1.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit RPA_C PF08784.11 AET38438.1 - 0.056 14.1 0.2 0.46 11.2 0.0 2.3 1 1 0 2 2 2 0 Replication protein A C terminal Rrf2 PF02082.20 AET38438.1 - 0.06 13.7 0.7 0.13 12.6 0.1 1.8 2 0 0 2 2 2 0 Transcriptional regulator B-block_TFIIIC PF04182.12 AET38438.1 - 0.16 12.2 2.2 0.69 10.1 0.2 2.4 1 1 1 2 2 2 0 B-block binding subunit of TFIIIC OPT PF03169.15 AET38439.1 - 5.1e-138 461.4 40.2 5.9e-138 461.2 40.2 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Gpr1_Fun34_YaaH PF01184.19 AET38441.1 - 1.5e-86 289.3 19.4 1.9e-86 289.0 19.4 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF2955 PF11168.8 AET38441.1 - 0.004 17.0 4.8 0.01 15.7 4.8 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2955) CoA_binding_3 PF13727.6 AET38441.1 - 2.3 8.2 5.0 4.2 7.3 5.0 1.4 1 0 0 1 1 1 0 CoA-binding domain BAR PF03114.18 AET38442.1 - 1.2e-54 185.5 1.2 1.5e-54 185.2 1.2 1.1 1 0 0 1 1 1 1 BAR domain DUF1496 PF07383.12 AET38442.1 - 0.0052 16.3 0.3 0.01 15.4 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1496) DUF4164 PF13747.6 AET38442.1 - 0.013 15.8 0.4 0.013 15.8 0.4 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) NADH_4Fe-4S PF10589.9 AET38442.1 - 0.06 13.4 0.0 0.21 11.7 0.0 1.9 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Jnk-SapK_ap_N PF09744.9 AET38442.1 - 4 7.7 8.3 0.33 11.2 1.3 2.4 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 Sterol-sensing PF12349.8 AET38443.1 - 0.00034 20.5 14.8 0.00074 19.4 13.1 2.6 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Pkinase PF00069.25 AET38444.1 - 2.9e-48 164.5 0.0 5e-48 163.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38444.1 - 2.7e-25 89.1 0.0 3.9e-25 88.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET38444.1 - 0.0061 15.9 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AET38444.1 - 0.15 12.0 0.2 0.38 10.6 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 AET38444.1 - 0.16 11.3 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RRM_1 PF00076.22 AET38445.1 - 4.8e-48 160.9 7.0 3.5e-17 62.0 0.5 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 AET38445.1 - 6.9e-05 22.8 0.2 1.2 9.3 0.0 3.9 3 0 0 3 3 3 2 RNA binding motif RRM_5 PF13893.6 AET38445.1 - 0.00032 20.3 0.0 8.5 6.0 0.0 3.5 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 AET38445.1 - 0.0006 19.7 0.0 1.7 8.7 0.1 3.2 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 AET38445.1 - 0.021 14.9 0.2 59 3.8 0.0 3.8 3 1 0 3 3 3 0 Limkain b1 RRM_7 PF16367.5 AET38445.1 - 0.065 13.4 0.1 1.6 8.9 0.0 3.2 3 1 0 3 3 3 0 RNA recognition motif Ysc84 PF04366.12 AET38446.1 - 6.8e-42 142.2 0.4 1.2e-41 141.5 0.4 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 AET38446.1 - 7.1e-16 57.5 0.1 1.4e-15 56.6 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AET38446.1 - 1.8e-12 46.9 0.1 4.7e-12 45.6 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AET38446.1 - 1.9e-11 43.5 0.0 3.7e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF3104 PF11302.8 AET38446.1 - 0.11 12.3 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) SAP25 PF15476.6 AET38446.1 - 0.22 11.1 1.0 0.58 9.8 0.0 2.0 2 0 0 2 2 2 0 Histone deacetylase complex subunit SAP25 DUF1776 PF08643.10 AET38447.1 - 1e-70 238.5 0.1 3.2e-70 236.9 0.0 1.7 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) adh_short PF00106.25 AET38447.1 - 0.025 14.0 0.0 0.042 13.3 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase DUF4110 PF13422.6 AET38447.1 - 0.036 14.1 0.0 0.068 13.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4110) Lyase_1 PF00206.20 AET38448.1 - 1.4e-96 323.6 0.0 2e-96 323.1 0.0 1.3 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 AET38448.1 - 4.7e-22 78.5 0.0 1.1e-21 77.4 0.0 1.6 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal tRNA-synt_2 PF00152.20 AET38449.1 - 2.6e-90 302.7 0.0 4.1e-90 302.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AET38449.1 - 5.4e-12 45.5 0.1 1.4e-11 44.2 0.1 1.8 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Ins134_P3_kin PF05770.11 AET38449.1 - 0.013 15.0 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain ProRS-C_1 PF09180.11 AET38450.1 - 5.2e-25 87.4 1.0 9.8e-25 86.6 1.0 1.5 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 AET38450.1 - 3.4e-18 65.6 0.0 1.2e-17 63.8 0.0 2.0 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 AET38450.1 - 6.1e-16 58.9 0.0 1.2e-15 58.0 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA_edit PF04073.15 AET38450.1 - 0.025 14.7 0.1 0.049 13.7 0.1 1.4 1 0 0 1 1 1 0 Aminoacyl-tRNA editing domain PHP PF02811.19 AET38451.1 - 1.4e-10 41.7 0.2 2.7e-10 40.8 0.2 1.5 1 1 0 1 1 1 1 PHP domain Translat_reg PF01818.17 AET38451.1 - 0.093 12.7 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 Bacteriophage translational regulator Flo11 PF10182.9 AET38452.1 - 8e-50 168.9 0.1 1.7e-49 167.8 0.1 1.6 1 0 0 1 1 1 1 Flo11 domain Collagen PF01391.18 AET38452.1 - 0.00014 21.6 17.8 0.00028 20.6 5.5 2.8 2 1 0 2 2 2 2 Collagen triple helix repeat (20 copies) Acetyltransf_13 PF13880.6 AET38453.1 - 2.2e-22 78.8 0.0 3.8e-22 78.0 0.0 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 AET38453.1 - 6.5e-08 32.3 0.3 1.1e-07 31.6 0.3 1.4 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_7 PF13508.7 AET38453.1 - 0.0031 17.9 0.0 0.0063 16.9 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 AET38453.1 - 0.0059 16.8 0.0 0.01 16.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AET38453.1 - 0.048 13.6 0.0 0.18 11.8 0.0 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DSPn PF14671.6 AET38454.1 - 2.2e-45 154.6 0.0 5.5e-45 153.3 0.0 1.7 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 AET38454.1 - 2.7e-23 82.2 0.0 5.3e-22 78.1 0.0 2.4 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AET38454.1 - 0.00033 20.3 0.0 0.00067 19.3 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 AET38454.1 - 0.0099 15.6 0.1 0.018 14.7 0.1 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) DTHCT PF08070.11 AET38454.1 - 1 10.2 6.2 36 5.2 0.0 2.4 2 0 0 2 2 2 0 DTHCT (NUC029) region Glutaredoxin PF00462.24 AET38456.1 - 1.2e-06 28.6 0.0 2.5e-06 27.6 0.0 1.6 1 1 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.6 AET38456.1 - 0.0019 18.6 0.1 0.0026 18.2 0.1 1.3 1 1 0 1 1 1 1 Thioredoxin-like domain DUF953 PF06110.11 AET38456.1 - 0.0022 17.6 0.8 0.0041 16.7 0.8 1.7 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_9 PF14595.6 AET38456.1 - 0.078 12.7 0.0 0.09 12.5 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Prd1-P2 PF09214.11 AET38456.1 - 0.18 10.5 0.0 0.19 10.4 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage Prd1, adsorption protein P2 MFS_1 PF07690.16 AET38457.1 - 4e-18 65.5 20.1 1.1e-17 64.1 15.9 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily 7TMR-DISM_7TM PF07695.11 AET38457.1 - 0.095 12.6 20.4 0.026 14.4 10.4 2.6 2 0 0 2 2 2 0 7TM diverse intracellular signalling Ribosomal_S8 PF00410.19 AET38458.1 - 3.6e-24 85.1 0.2 5.9e-24 84.4 0.2 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 zf-C2H2 PF00096.26 AET38459.1 - 5.4e-06 26.6 16.1 8.2e-05 22.8 2.6 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AET38459.1 - 0.00019 21.7 4.7 0.00019 21.7 4.7 3.5 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 AET38459.1 - 0.0068 17.2 19.7 0.018 15.8 2.6 4.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 AET38459.1 - 0.29 10.9 1.7 0.7 9.7 1.7 1.7 1 0 0 1 1 1 0 C2H2-type zinc-finger domain Arrestin_C PF02752.22 AET38460.1 - 4.5e-17 62.8 1.8 3.2e-16 60.0 1.8 2.3 1 1 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 AET38460.1 - 0.0003 20.9 0.2 0.015 15.4 0.0 2.7 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain F-box PF00646.33 AET38461.1 - 0.00037 20.3 4.1 0.00064 19.5 1.0 3.0 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 AET38461.1 - 0.0043 16.9 3.8 0.015 15.2 3.8 1.9 1 0 0 1 1 1 1 F-box-like Sgf11_N PF18519.1 AET38461.1 - 0.078 12.5 0.2 0.31 10.6 0.2 2.1 2 0 0 2 2 2 0 SAGA-associated factor 11 N-terminal domain HSP70 PF00012.20 AET38462.1 - 1.1e-216 720.8 6.7 1.2e-216 720.6 6.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AET38462.1 - 3.1e-19 69.0 1.9 4.8e-16 58.5 0.3 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 AET38462.1 - 2.9e-07 30.4 0.0 9e-07 28.8 0.0 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 AET38462.1 - 0.0038 16.8 0.1 0.11 12.0 0.0 2.5 2 1 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family NLRC4_HD PF17889.1 AET38462.1 - 0.085 13.2 0.2 0.37 11.2 0.2 2.0 1 0 0 1 1 1 0 NLRC4 helical domain FtsA PF14450.6 AET38462.1 - 0.59 10.6 3.5 28 5.2 0.1 3.6 3 2 0 3 3 3 0 Cell division protein FtsA GlutR_dimer PF00745.20 AET38462.1 - 1 9.9 4.6 5.9 7.4 0.1 3.4 5 0 0 5 5 5 0 Glutamyl-tRNAGlu reductase, dimerisation domain P21-Arc PF04062.14 AET38463.1 - 1.6e-71 239.9 0.0 1.8e-71 239.7 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit CNH PF00780.22 AET38464.1 - 7.3e-78 261.9 0.2 7.3e-78 261.9 0.2 1.5 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.6 AET38464.1 - 4.7e-36 123.9 0.0 4.7e-36 123.9 0.0 2.7 2 1 0 2 2 2 1 Pleckstrin homology domain RhoGEF PF00621.20 AET38464.1 - 3.3e-30 105.7 0.1 3.3e-30 105.7 0.1 2.8 2 1 1 3 3 3 1 RhoGEF domain DEP PF00610.21 AET38464.1 - 5.9e-15 55.1 0.0 1.5e-14 53.7 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ELO PF01151.18 AET38465.1 - 2.1e-61 207.6 21.0 2.7e-61 207.2 21.0 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family zf-BED PF02892.15 AET38466.1 - 0.0084 16.1 9.0 0.0084 16.1 9.0 2.0 2 0 0 2 2 2 1 BED zinc finger Crystallin PF00525.18 AET38466.1 - 0.034 14.3 0.0 1.1 9.4 0.0 2.6 2 0 0 2 2 2 0 Alpha crystallin A chain, N terminal Menin PF05053.13 AET38466.1 - 0.11 10.8 4.5 0.074 11.4 2.4 1.6 2 0 0 2 2 2 0 Menin zf-C2H2_6 PF13912.6 AET38467.1 - 0.00015 21.6 1.9 0.00015 21.6 1.9 3.8 3 1 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 AET38467.1 - 0.0004 21.0 1.6 0.0004 21.0 1.6 6.0 5 1 0 5 5 5 3 C2H2-type zinc finger zf-C2H2 PF00096.26 AET38467.1 - 0.00076 19.8 2.8 0.00076 19.8 2.8 6.1 5 1 0 5 5 5 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 AET38467.1 - 0.0064 16.7 0.1 0.0064 16.7 0.1 4.7 5 0 0 5 5 5 1 Zinc-finger double-stranded RNA-binding TFIIA PF03153.13 AET38467.1 - 0.046 13.7 5.4 0.059 13.4 5.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit zf-H2C2_2 PF13465.6 AET38467.1 - 0.089 13.3 0.8 0.089 13.3 0.8 5.8 4 1 1 5 5 5 0 Zinc-finger double domain zf-C2HC_2 PF13913.6 AET38467.1 - 0.65 10.0 11.9 0.55 10.2 1.3 3.4 3 0 0 3 3 3 0 zinc-finger of a C2HC-type MSP1_C PF07462.11 AET38467.1 - 4.6 5.8 4.9 6.9 5.2 4.9 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus FA_desaturase PF00487.24 AET38468.1 - 7.3e-21 75.1 29.3 1.5e-20 74.1 29.3 1.4 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 AET38468.1 - 0.0043 17.3 0.0 0.0076 16.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) KRE9 PF05390.11 AET38469.1 - 1.5e-41 141.2 4.8 1.5e-41 141.2 4.8 1.7 2 0 0 2 2 2 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.9 AET38469.1 - 8.3e-05 23.3 0.6 0.00018 22.2 0.0 1.8 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family La PF05383.17 AET38470.1 - 5.2e-22 77.6 0.1 1.7e-21 76.0 0.1 1.9 2 0 0 2 2 2 1 La domain BRAP2 PF07576.12 AET38470.1 - 0.0055 16.9 0.2 0.011 15.9 0.2 1.5 1 0 0 1 1 1 1 BRCA1-associated protein 2 PSY3 PF16836.5 AET38471.1 - 3.1e-66 223.0 0.0 3.5e-66 222.8 0.0 1.0 1 0 0 1 1 1 1 Shu complex component Psy3, DNA-binding description Acyltransferase PF01553.21 AET38472.1 - 1.5e-33 115.3 0.0 2.3e-33 114.7 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase FBPase PF00316.20 AET38473.1 - 4.1e-82 274.3 0.4 5.3e-82 273.9 0.4 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 AET38473.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Inositol monophosphatase family FAM199X PF15814.5 AET38474.1 - 5.6 5.9 10.4 1.9 7.5 7.7 1.7 1 1 0 1 1 1 0 Protein family FAM199X MFS_1 PF07690.16 AET38475.1 - 5.1e-10 38.8 37.2 4.4e-07 29.1 18.1 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily SecY PF00344.20 AET38476.1 - 5.2e-61 206.6 11.5 6.4e-61 206.3 11.5 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 AET38476.1 - 9.4e-18 63.8 0.2 3.6e-17 61.9 0.2 2.1 1 0 0 1 1 1 1 Plug domain of Sec61p SdpI PF13630.6 AET38476.1 - 0.044 13.9 0.3 0.044 13.9 0.3 2.4 2 0 0 2 2 2 0 SdpI/YhfL protein family Glyco_hydro_85 PF03644.13 AET38477.1 - 7.8e-74 248.8 4.0 1.1e-73 248.4 4.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 DUF553 PF04473.12 AET38478.1 - 0.082 12.4 0.1 0.11 12.0 0.1 1.2 1 0 0 1 1 1 0 Transglutaminase-like domain Transp_cyt_pur PF02133.15 AET38479.1 - 5.5e-151 503.3 34.8 6.5e-151 503.0 34.8 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin NTP_transferase PF00483.23 AET38480.1 - 8.8e-53 179.4 0.0 1.1e-52 179.1 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 AET38480.1 - 3.7e-10 40.4 0.0 4.7e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 AET38480.1 - 1.2e-09 37.5 7.3 4.6e-08 32.5 2.9 3.3 1 1 2 3 3 3 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 AET38480.1 - 0.001 17.3 0.5 0.0015 16.8 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 AET38480.1 - 0.0028 16.7 0.2 0.02 13.8 0.2 2.0 2 0 0 2 2 2 1 L-fucokinase Hexapep_2 PF14602.6 AET38480.1 - 0.018 14.8 3.8 0.42 10.4 0.7 3.3 4 0 0 4 4 4 0 Hexapeptide repeat of succinyl-transferase IspD PF01128.19 AET38480.1 - 0.11 12.2 0.0 0.55 9.9 0.0 2.0 2 0 0 2 2 2 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Ank_4 PF13637.6 AET38481.1 - 3.3e-17 62.6 0.6 3.7e-07 30.6 0.2 3.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 AET38481.1 - 1.6e-14 54.2 0.1 7e-06 26.5 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 AET38481.1 - 2.8e-11 43.3 0.4 0.0033 17.8 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 AET38481.1 - 1.7e-09 37.1 0.1 0.0076 16.7 0.1 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 AET38481.1 - 1.3e-07 31.7 0.2 0.028 14.7 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) KilA-N PF04383.13 AET38481.1 - 5.7e-07 29.4 2.3 1.4e-06 28.1 0.3 2.7 2 1 0 2 2 2 1 KilA-N domain Flu_NS2 PF00601.19 AET38481.1 - 0.011 16.0 4.8 0.011 16.0 4.8 1.8 2 0 0 2 2 2 0 Influenza non-structural protein (NS2) TFIID_20kDa PF03847.13 AET38481.1 - 0.022 15.3 2.8 2 9.0 0.0 3.6 3 0 0 3 3 3 0 Transcription initiation factor TFIID subunit A ALMT PF11744.8 AET38481.1 - 0.098 11.5 4.7 0.17 10.7 4.7 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Baculo_PEP_C PF04513.12 AET38481.1 - 0.13 12.2 6.4 0.06 13.4 1.3 2.7 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMPIT PF07851.13 AET38481.1 - 8.7 5.5 9.2 5.3 6.2 4.7 2.4 2 1 0 2 2 2 0 TMPIT-like protein Y_phosphatase3 PF13350.6 AET38482.1 - 3.7e-38 131.8 0.0 7.5e-38 130.8 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Hydrolase_4 PF12146.8 AET38482.1 - 2.3e-08 33.6 0.5 4.6e-08 32.6 0.3 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AET38482.1 - 0.0027 17.4 0.3 0.031 13.9 0.1 2.2 1 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AET38482.1 - 0.0038 17.9 0.0 0.029 15.0 0.0 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Y_phosphatase2 PF03162.13 AET38482.1 - 0.013 15.1 0.0 0.031 13.9 0.0 1.7 1 1 0 1 1 1 0 Tyrosine phosphatase family DHBP_synthase PF00926.19 AET38483.1 - 2.4e-80 268.6 0.1 2.8e-80 268.4 0.1 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase tRNA-synt_1b PF00579.25 AET38484.1 - 1.3e-16 60.7 0.0 5e-11 42.5 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (W and Y) Snf7 PF03357.21 AET38485.1 - 5.1e-37 127.1 18.6 6.1e-37 126.9 18.6 1.1 1 0 0 1 1 1 1 Snf7 APG17 PF04108.12 AET38485.1 - 0.0057 15.8 6.7 0.0077 15.4 6.7 1.3 1 0 0 1 1 1 1 Autophagy protein Apg17 YlqD PF11068.8 AET38485.1 - 0.007 16.7 8.3 0.007 16.7 8.3 2.3 1 1 1 2 2 2 1 YlqD protein FliJ PF02050.16 AET38485.1 - 0.013 15.7 6.7 0.013 15.7 6.7 2.5 1 1 2 3 3 3 0 Flagellar FliJ protein Seryl_tRNA_N PF02403.22 AET38485.1 - 0.057 13.6 11.7 0.92 9.8 3.3 2.8 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Cep57_MT_bd PF06657.13 AET38485.1 - 0.1 13.0 12.4 0.11 13.0 2.9 2.5 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Spc7 PF08317.11 AET38485.1 - 0.19 10.6 15.5 0.29 10.0 8.9 2.0 1 1 0 1 1 1 0 Spc7 kinetochore protein Fib_alpha PF08702.10 AET38485.1 - 0.2 11.9 15.4 1.9 8.7 1.7 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family 5_3_exonuc PF01367.20 AET38485.1 - 2.6 8.7 5.9 12 6.6 1.2 3.1 2 1 1 3 3 3 0 5'-3' exonuclease, C-terminal SAM fold Atg14 PF10186.9 AET38485.1 - 4.5 6.2 12.7 8.5 5.4 12.7 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.12 AET38485.1 - 5 7.2 13.1 2.3 8.3 3.2 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Methyltransf_23 PF13489.6 AET38486.1 - 1.8e-20 73.4 0.0 2.8e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AET38486.1 - 4.6e-14 52.5 0.0 7.3e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AET38486.1 - 1.5e-13 51.2 0.0 3.9e-13 49.9 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AET38486.1 - 2.9e-12 47.2 0.0 6.5e-12 46.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AET38486.1 - 3.2e-12 47.0 0.0 8.1e-12 45.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 AET38486.1 - 3.9e-07 29.7 0.0 6e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 AET38486.1 - 1.4e-06 27.9 0.0 1.9e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.11 AET38486.1 - 1.4e-06 28.1 0.0 2e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) DREV PF05219.12 AET38486.1 - 1.8e-06 27.2 0.0 2.5e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase MTS PF05175.14 AET38486.1 - 3.2e-05 23.6 0.0 8.5e-05 22.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 AET38486.1 - 0.0015 18.6 0.0 0.0025 17.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 AET38486.1 - 0.0022 17.6 0.4 0.0067 16.0 0.0 1.9 2 1 0 2 2 2 1 Methionine biosynthesis protein MetW Methyltransf_18 PF12847.7 AET38486.1 - 0.032 14.2 0.0 0.061 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain YL1 PF05764.13 AET38487.1 - 1.4e-49 169.5 28.9 1.4e-49 169.5 28.9 2.6 2 1 0 2 2 2 1 YL1 nuclear protein YL1_C PF08265.11 AET38487.1 - 4.5e-10 39.1 0.1 4.5e-10 39.1 0.1 1.6 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain UvrD-helicase PF00580.21 AET38488.1 - 5.8e-34 118.0 0.6 6e-18 65.4 0.0 3.0 2 1 1 3 3 3 2 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 AET38488.1 - 5.7e-27 95.0 0.2 1.5e-25 90.4 0.1 2.8 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 AET38488.1 - 1.3e-26 93.7 0.0 6.2e-26 91.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 AET38488.1 - 2.1e-10 40.3 0.0 4.3e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_11 PF13086.6 AET38488.1 - 4.2e-08 33.3 0.0 2.6e-07 30.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 AET38488.1 - 1.6e-07 31.3 0.0 0.082 12.6 0.0 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_12 PF13087.6 AET38488.1 - 4e-05 23.3 0.2 0.029 14.0 0.0 3.7 2 2 1 3 3 3 1 AAA domain AAA_30 PF13604.6 AET38488.1 - 0.0089 15.8 0.0 0.33 10.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain Vps52 PF04129.12 AET38489.1 - 6.9e-136 454.0 14.9 9.2e-136 453.6 14.9 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family ComX PF05952.12 AET38489.1 - 0.082 12.9 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 Bacillus competence pheromone ComX Mer2 PF09074.10 AET38489.1 - 7.5 6.3 8.7 0.5 10.1 1.0 2.8 3 1 0 3 3 3 0 Mer2 Rep_fac_C PF08542.11 AET38490.1 - 2.6e-22 79.0 0.2 9.4e-22 77.2 0.0 2.1 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA PF00004.29 AET38490.1 - 7.9e-14 52.2 0.0 1.5e-13 51.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 AET38490.1 - 3.3e-13 49.7 0.1 1e-10 41.6 0.1 2.3 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA_14 PF13173.6 AET38490.1 - 1.1e-06 28.8 0.0 2e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AET38490.1 - 1.9e-06 28.4 0.0 0.00022 21.7 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AET38490.1 - 1.1e-05 25.7 0.3 0.12 12.7 0.1 3.0 2 1 1 3 3 3 2 AAA domain RuvB_N PF05496.12 AET38490.1 - 1.9e-05 24.5 0.0 5.9e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 AET38490.1 - 2.4e-05 24.2 0.0 4.7e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 AET38490.1 - 5.2e-05 23.1 0.0 8.4e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase Rad17 PF03215.15 AET38490.1 - 0.00018 21.5 0.0 0.00082 19.3 0.0 1.9 1 1 1 2 2 2 1 Rad17 P-loop domain Mg_chelatase PF01078.21 AET38490.1 - 0.00067 19.1 0.0 0.0099 15.3 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_assoc_2 PF16193.5 AET38490.1 - 0.0057 17.0 0.0 0.022 15.1 0.0 2.1 2 0 0 2 2 2 1 AAA C-terminal domain AAA_19 PF13245.6 AET38490.1 - 0.0059 17.0 0.1 0.02 15.2 0.1 2.0 1 1 0 1 1 1 1 AAA domain TniB PF05621.11 AET38490.1 - 0.0066 15.9 0.0 4.3 6.7 0.0 2.4 2 0 0 2 2 2 2 Bacterial TniB protein NTPase_1 PF03266.15 AET38490.1 - 0.0077 16.2 0.1 0.08 12.8 0.1 2.3 1 1 1 2 2 2 1 NTPase MeaB PF03308.16 AET38490.1 - 0.016 14.2 0.0 0.11 11.4 0.0 2.1 1 1 1 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DNA_pol3_delta PF06144.13 AET38490.1 - 0.019 14.8 0.2 0.031 14.1 0.2 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_24 PF13479.6 AET38490.1 - 0.027 14.2 0.0 0.075 12.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain MCM PF00493.23 AET38490.1 - 0.048 12.8 0.0 0.088 11.9 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_11 PF13086.6 AET38490.1 - 0.083 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 AET38490.1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DEAD PF00270.29 AET38490.1 - 0.12 12.2 0.1 1.2 8.9 0.0 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_30 PF13604.6 AET38490.1 - 0.13 12.0 0.0 0.44 10.2 0.0 1.9 1 1 0 1 1 1 0 AAA domain tRNA_m1G_MT PF01746.21 AET38491.1 - 4.1e-38 131.1 0.2 6.5e-38 130.4 0.2 1.3 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase PQ-loop PF04193.14 AET38492.1 - 3e-43 145.4 11.4 4.7e-24 83.9 0.9 2.8 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 AET38492.1 - 0.025 14.6 9.5 1.5 8.9 0.4 3.5 2 1 1 3 3 3 0 Sugar efflux transporter for intercellular exchange PUB_1 PF18486.1 AET38492.1 - 0.15 11.9 0.3 55 3.7 0.0 3.2 3 0 0 3 3 3 0 PNGase/UBA- or UBX-containing domain DUF2530 PF10745.9 AET38492.1 - 2.3 8.5 4.4 7.3 6.9 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2530) DUF1664 PF07889.12 AET38493.1 - 0.077 13.0 30.1 1.1 9.4 3.0 4.5 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) CALCOCO1 PF07888.11 AET38493.1 - 1.7 7.4 42.7 0.29 9.9 30.4 2.5 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like NPV_P10 PF05531.12 AET38493.1 - 6.1 7.4 18.7 11 6.5 0.2 5.3 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein MutS_V PF00488.21 AET38494.1 - 4.4e-83 277.9 0.3 9.2e-83 276.9 0.3 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 AET38494.1 - 1.8e-33 116.4 2.0 1.8e-33 116.4 2.0 2.3 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 AET38494.1 - 2.7e-18 66.1 1.0 2.7e-18 66.1 1.0 2.6 3 0 0 3 3 3 1 MutS family domain IV MutS_II PF05188.17 AET38494.1 - 1e-16 61.4 0.1 3.5e-16 59.7 0.1 2.0 1 0 0 1 1 1 1 MutS domain II MutS_I PF01624.20 AET38494.1 - 2.2e-07 31.1 0.0 8.5e-07 29.2 0.0 2.0 2 0 0 2 2 2 1 MutS domain I Rad17 PF03215.15 AET38494.1 - 0.0068 16.3 0.5 0.23 11.4 0.0 3.0 3 0 0 3 3 3 1 Rad17 P-loop domain Vmethyltransf_C PF08456.10 AET38494.1 - 0.13 11.8 1.5 0.31 10.6 0.2 2.3 3 0 0 3 3 3 0 Viral methyltransferase C-terminal AAA_23 PF13476.6 AET38494.1 - 5.8 7.4 17.7 12 6.3 2.2 4.2 3 1 0 3 3 3 0 AAA domain V-SNARE PF05008.15 AET38494.1 - 7.1 7.1 8.5 18 5.8 0.2 3.8 3 0 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus Sugar_tr PF00083.24 AET38495.1 - 2.1e-119 399.3 37.0 2.5e-119 399.1 37.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AET38495.1 - 7.5e-19 67.9 42.2 2.1e-17 63.1 30.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sod_Fe_C PF02777.18 AET38496.1 - 9.9e-35 118.8 0.1 1.6e-34 118.1 0.1 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 AET38496.1 - 1.2e-25 89.7 0.7 2.1e-25 89.0 0.7 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain HHH_2 PF12826.7 AET38496.1 - 0.18 12.0 0.0 0.38 10.9 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif PWWP PF00855.17 AET38499.1 - 1.5e-16 60.6 0.1 3.2e-16 59.5 0.1 1.6 1 0 0 1 1 1 1 PWWP domain Putative_PNPOx PF01243.20 AET38500.1 - 7.9e-15 54.8 0.0 2.1e-14 53.5 0.0 1.7 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 AET38500.1 - 0.00079 19.4 0.0 0.034 14.1 0.0 2.1 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyrid_oxidase_2 PF13883.6 AET38500.1 - 0.0045 17.0 0.1 0.0093 15.9 0.1 1.5 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 AET38500.1 - 0.0073 15.9 0.0 2.3 7.8 0.0 2.2 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase like AAA PF00004.29 AET38501.1 - 1.2e-43 148.7 0.0 2e-43 148.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 AET38501.1 - 1.1e-30 105.4 0.1 4.6e-30 103.4 0.3 2.0 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 AET38501.1 - 2.2e-22 78.9 2.0 5.6e-22 77.6 2.0 1.8 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 AET38501.1 - 2.9e-06 27.0 0.0 3.9e-05 23.4 0.0 2.6 2 0 0 2 2 2 1 AAA+ lid domain RuvB_N PF05496.12 AET38501.1 - 5.8e-06 26.1 0.0 9.7e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AET38501.1 - 6.7e-06 26.6 0.1 6.6e-05 23.3 0.0 2.4 2 1 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.6 AET38501.1 - 1e-05 25.8 0.1 0.00085 19.6 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AET38501.1 - 2.5e-05 24.3 0.0 9.2e-05 22.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 AET38501.1 - 6.9e-05 22.6 0.0 0.00013 21.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 AET38501.1 - 8.7e-05 22.9 0.1 0.0091 16.4 0.0 3.1 3 0 0 3 3 3 1 RNA helicase DUF815 PF05673.13 AET38501.1 - 9e-05 21.8 0.0 0.00039 19.7 0.0 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF815) TIP49 PF06068.13 AET38501.1 - 0.00011 21.6 0.0 0.00019 20.8 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 AET38501.1 - 0.00011 22.2 0.1 0.00034 20.6 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 AET38501.1 - 0.00089 19.8 0.0 0.0023 18.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 AET38501.1 - 0.0011 19.1 0.0 0.0026 17.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 AET38501.1 - 0.0021 18.2 0.0 0.0053 16.9 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_24 PF13479.6 AET38501.1 - 0.0043 16.8 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 AET38501.1 - 0.0083 15.7 0.1 0.29 10.7 0.1 2.2 1 1 1 2 2 2 1 AAA domain ATPase PF06745.13 AET38501.1 - 0.0088 15.4 0.0 2.9 7.2 0.0 2.2 1 1 1 2 2 2 1 KaiC AAA_17 PF13207.6 AET38501.1 - 0.012 16.1 0.0 0.034 14.6 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_7 PF12775.7 AET38501.1 - 0.033 13.7 0.0 0.096 12.2 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 AET38501.1 - 0.037 13.4 0.0 0.082 12.3 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Torsin PF06309.11 AET38501.1 - 0.045 13.9 0.0 0.089 12.9 0.0 1.4 1 0 0 1 1 1 0 Torsin Use1 PF09753.9 AET38501.1 - 0.057 13.1 0.2 0.12 12.1 0.2 1.4 1 0 0 1 1 1 0 Membrane fusion protein Use1 PhoH PF02562.16 AET38501.1 - 0.081 12.4 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein Zeta_toxin PF06414.12 AET38501.1 - 0.094 12.0 0.2 1.2 8.4 0.1 2.4 1 1 2 3 3 3 0 Zeta toxin Sigma54_activat PF00158.26 AET38501.1 - 0.095 12.4 0.0 0.29 10.8 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain Parvo_NS1 PF01057.17 AET38501.1 - 0.097 11.7 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NACHT PF05729.12 AET38501.1 - 0.13 12.2 0.0 0.55 10.1 0.0 2.0 1 1 0 1 1 1 0 NACHT domain ATPase_2 PF01637.18 AET38501.1 - 0.15 11.9 1.2 2.3 8.1 0.0 2.6 2 1 1 3 3 2 0 ATPase domain predominantly from Archaea CPT PF07931.12 AET38501.1 - 0.18 11.6 0.0 0.35 10.7 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein NBP1 PF08537.10 AET38502.1 - 4.1e-112 375.0 27.2 4.8e-112 374.7 27.2 1.0 1 0 0 1 1 1 1 Fungal Nap binding protein NBP1 Pox_VERT_large PF04441.13 AET38502.1 - 0.044 12.0 0.1 0.063 11.5 0.1 1.1 1 0 0 1 1 1 0 Poxvirus early transcription factor (VETF), large subunit DUF4140 PF13600.6 AET38502.1 - 5.4 7.5 8.5 1.4 9.4 1.6 2.6 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DNA_pol_E_B PF04042.16 AET38503.1 - 2.8e-45 154.3 2.2 4.6e-45 153.6 2.2 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B S1_2 PF13509.6 AET38503.1 - 0.1 12.7 0.0 9.4 6.4 0.0 2.7 2 0 0 2 2 2 0 S1 domain Prenyltrans PF00432.21 AET38504.1 - 4.4e-63 208.7 5.0 7.6e-13 48.0 0.0 6.1 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 AET38504.1 - 1.2e-06 27.9 0.0 6.8e-05 22.1 0.0 2.7 1 1 2 3 3 3 1 Squalene-hopene cyclase C-terminal domain TED_complement PF07678.14 AET38504.1 - 0.00051 19.2 0.0 0.042 12.9 0.0 3.1 3 1 1 4 4 4 1 A-macroglobulin TED domain SQHop_cyclase_N PF13249.6 AET38504.1 - 0.0018 17.4 0.0 9.4 5.2 0.0 4.2 1 1 4 5 5 5 2 Squalene-hopene cyclase N-terminal domain WD40 PF00400.32 AET38505.1 - 8.5e-34 115.0 15.9 1.3e-08 35.3 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET38505.1 - 7.1e-17 61.5 1.0 0.0015 18.8 0.0 6.3 2 1 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AET38505.1 - 0.00017 21.5 0.0 0.075 12.9 0.0 2.7 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 AET38505.1 - 0.0002 20.0 0.0 0.46 8.9 0.0 2.2 2 0 0 2 2 2 2 Cytochrome D1 heme domain WD40_like PF17005.5 AET38505.1 - 0.0036 16.7 0.1 3.6 6.8 0.0 3.6 2 1 2 4 4 4 1 WD40-like domain Ge1_WD40 PF16529.5 AET38505.1 - 0.033 13.2 0.0 1.3 7.9 0.0 2.6 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein HDA2-3 PF11496.8 AET38506.1 - 4.1e-96 321.6 1.4 4.1e-96 321.6 1.4 2.2 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 CtIP_N PF10482.9 AET38506.1 - 0.13 12.4 14.4 0.033 14.2 8.7 2.4 1 1 1 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain Tsg PF04668.12 AET38506.1 - 0.26 12.0 0.8 0.67 10.6 0.8 1.8 1 0 0 1 1 1 0 Twisted gastrulation (Tsg) protein conserved region GLE1 PF07817.13 AET38506.1 - 0.54 9.4 6.1 6.4 5.9 1.2 2.3 2 0 0 2 2 2 0 GLE1-like protein DUF4407 PF14362.6 AET38506.1 - 3.9 6.7 11.1 6 6.1 11.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.12 AET38506.1 - 4.4 7.3 8.2 1 9.4 2.4 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 AET38506.1 - 9.6 6.3 8.9 6 6.9 5.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Sec23_trunk PF04811.15 AET38507.1 - 5.7e-73 245.5 0.0 7.7e-73 245.0 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 AET38507.1 - 1.8e-28 99.1 0.0 3.3e-28 98.3 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 AET38507.1 - 2e-27 95.0 0.0 4.5e-27 93.9 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 AET38507.1 - 5.1e-14 52.0 2.3 8.8e-14 51.3 2.3 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 AET38507.1 - 9.7e-12 44.6 0.0 1.9e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 AET38507.1 - 0.075 12.4 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain MHC_I PF00129.18 AET38507.1 - 0.077 12.5 0.0 0.3 10.6 0.0 1.9 2 0 0 2 2 2 0 Class I Histocompatibility antigen, domains alpha 1 and 2 Pterin_4a PF01329.19 AET38507.1 - 0.09 13.0 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Pterin 4 alpha carbinolamine dehydratase PIG-U PF06728.13 AET38508.1 - 5.5e-102 341.7 42.5 7.8e-102 341.2 42.5 1.2 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U LSM PF01423.22 AET38509.1 - 4.2e-16 58.4 0.3 4.8e-16 58.2 0.3 1.0 1 0 0 1 1 1 1 LSM domain Peptidase_M26_C PF07580.14 AET38509.1 - 0.017 13.6 0.0 0.021 13.4 0.0 1.0 1 0 0 1 1 1 0 M26 IgA1-specific Metallo-endopeptidase C-terminal region Glycos_transf_2 PF00535.26 AET38510.1 - 8.8e-34 116.8 0.0 1.1e-33 116.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AET38510.1 - 1.7e-09 37.9 0.0 2.8e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 AET38510.1 - 0.00094 18.7 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 DUF3961 PF13106.6 AET38510.1 - 0.42 10.3 3.3 0.66 9.7 1.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3961) hDGE_amylase PF14701.6 AET38511.1 - 2.1e-167 557.7 0.3 2.8e-167 557.3 0.3 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 AET38511.1 - 7.8e-120 400.3 0.0 1.1e-119 399.8 0.0 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 AET38511.1 - 3.8e-74 249.5 0.0 7.3e-74 248.6 0.0 1.5 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 AET38511.1 - 2.3e-23 82.1 0.0 6.5e-23 80.7 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.24 AET38511.1 - 6.2e-06 26.0 0.1 2.5e-05 24.0 0.1 1.8 2 0 0 2 2 2 1 Alpha amylase, catalytic domain DUF4038 PF13204.6 AET38511.1 - 0.013 15.2 0.0 0.049 13.3 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4038) ATG13 PF10033.9 AET38512.1 - 2.6e-68 230.3 0.1 4.9e-68 229.4 0.1 1.5 1 0 0 1 1 1 1 Autophagy-related protein 13 zf-C2H2 PF00096.26 AET38513.1 - 5.3e-32 108.5 56.6 4.8e-05 23.6 0.5 9.3 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AET38513.1 - 5.4e-22 76.6 58.6 0.0012 19.5 4.5 9.4 9 0 0 9 9 9 9 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AET38513.1 - 1.3e-10 41.2 62.5 0.00058 20.2 0.2 9.8 10 0 0 10 10 10 5 Zinc-finger double domain zf-C2H2_jaz PF12171.8 AET38513.1 - 5.5e-08 32.9 32.4 0.032 14.5 0.5 8.5 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 AET38513.1 - 3.1e-06 27.4 36.4 0.49 10.8 0.3 9.2 9 0 0 9 9 9 4 Zinc-finger of C2H2 type FOXP-CC PF16159.5 AET38513.1 - 0.00026 21.5 28.8 0.18 12.4 1.8 6.2 4 2 3 7 7 7 4 FOXP coiled-coil domain Zn-ribbon_8 PF09723.10 AET38513.1 - 0.39 10.9 17.9 0.15 12.2 2.1 4.0 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2H2_8 PF15909.5 AET38513.1 - 0.68 10.3 31.2 2.6 8.4 0.1 4.9 2 1 4 6 6 6 0 C2H2-type zinc ribbon zf-LYAR PF08790.11 AET38513.1 - 0.81 9.7 17.4 1.3 9.0 0.1 5.8 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger RNA_pol_Rpb6 PF01192.22 AET38514.1 - 8.3e-17 60.9 0.1 1.2e-16 60.3 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 DUF4778 PF16008.5 AET38514.1 - 0.071 13.2 0.2 0.08 13.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) EF-hand_6 PF13405.6 AET38515.1 - 4.8e-06 26.1 3.6 0.00035 20.3 0.2 3.9 3 2 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 AET38515.1 - 1.1e-05 24.6 1.5 0.00063 19.1 0.2 3.6 3 1 1 4 4 4 1 EF hand EF-hand_7 PF13499.6 AET38515.1 - 3.5e-05 24.2 0.5 7.1e-05 23.2 0.1 1.8 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 AET38515.1 - 0.00032 20.1 2.6 0.00032 20.1 2.6 2.1 2 0 0 2 2 2 1 EF hand DUF1877 PF08974.10 AET38515.1 - 0.018 15.1 0.0 0.035 14.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1877) EF-hand_8 PF13833.6 AET38515.1 - 0.043 13.7 1.6 2.4 8.1 0.1 3.0 1 1 2 3 3 3 0 EF-hand domain pair DUF4925 PF16272.5 AET38515.1 - 0.062 12.8 0.0 0.083 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4925) TPR_22 PF18833.1 AET38516.1 - 5.2e-38 129.0 2.2 1.1e-37 128.0 0.8 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 AET38516.1 - 2.3e-22 79.3 8.0 8.1e-06 26.3 0.0 8.4 6 3 3 9 9 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 AET38516.1 - 7.1e-21 72.6 20.7 0.00014 21.7 0.0 13.0 15 0 0 15 15 11 4 Tetratricopeptide repeat TPR_14 PF13428.6 AET38516.1 - 1.7e-18 65.7 2.4 0.0036 18.0 0.0 10.0 7 2 4 11 11 10 3 Tetratricopeptide repeat TPR_1 PF00515.28 AET38516.1 - 6.6e-18 63.7 19.5 3.6e-05 23.4 0.0 11.6 13 1 0 13 13 13 4 Tetratricopeptide repeat TPR_16 PF13432.6 AET38516.1 - 9.6e-17 61.4 0.5 0.0003 21.4 0.0 8.8 7 2 2 9 9 9 4 Tetratricopeptide repeat TPR_17 PF13431.6 AET38516.1 - 2.3e-15 55.8 10.5 0.026 14.9 0.0 10.4 11 0 0 11 11 10 3 Tetratricopeptide repeat TPR_6 PF13174.6 AET38516.1 - 6.8e-13 48.3 0.1 0.029 15.0 0.0 8.6 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 AET38516.1 - 2.8e-12 45.8 7.6 0.00017 21.5 0.0 8.4 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 AET38516.1 - 1.1e-10 41.0 12.9 0.0028 17.3 0.0 7.9 8 0 0 8 8 8 2 TPR repeat TPR_12 PF13424.6 AET38516.1 - 3.8e-10 39.9 9.1 1 9.7 0.1 8.2 5 2 2 8 8 8 3 Tetratricopeptide repeat TPR_7 PF13176.6 AET38516.1 - 1.3e-07 31.1 0.6 10 6.4 0.0 7.6 9 0 0 9 9 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 AET38516.1 - 6e-07 29.6 12.5 0.0013 18.9 0.3 5.6 6 1 1 7 7 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 AET38516.1 - 2e-05 24.1 0.7 0.11 11.8 0.0 3.8 4 0 0 4 4 4 2 MalT-like TPR region TPR_9 PF13371.6 AET38516.1 - 0.00077 19.6 0.1 1.6 8.9 0.1 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat RPN7 PF10602.9 AET38516.1 - 0.0017 18.1 0.7 6.9 6.3 0.0 4.6 4 0 0 4 4 4 1 26S proteasome subunit RPN7 TPR_20 PF14561.6 AET38516.1 - 0.0021 18.3 5.2 2.2 8.7 0.0 5.7 5 2 1 6 6 6 1 Tetratricopeptide repeat Coatomer_E PF04733.14 AET38516.1 - 0.0072 15.8 0.0 0.039 13.4 0.0 2.2 2 0 0 2 2 2 1 Coatomer epsilon subunit Alkyl_sulf_dimr PF14863.6 AET38516.1 - 0.015 15.8 0.9 4.3 7.8 0.0 3.6 3 1 1 4 4 4 0 Alkyl sulfatase dimerisation TPR_10 PF13374.6 AET38516.1 - 0.017 14.9 0.3 11 6.1 0.0 5.1 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_5 PF12688.7 AET38516.1 - 0.043 14.0 0.3 0.59 10.4 0.0 2.8 2 0 0 2 2 2 0 Tetratrico peptide repeat BTAD PF03704.17 AET38516.1 - 0.071 13.6 0.0 2.1 8.8 0.0 3.1 3 0 0 3 3 3 0 Bacterial transcriptional activator domain YhdB PF14148.6 AET38516.1 - 0.19 11.8 1.9 0.59 10.3 0.0 2.8 3 0 0 3 3 2 0 YhdB-like protein RNA_pol_Rpc82 PF05645.13 AET38517.1 - 2.4e-62 211.0 0.2 4.4e-62 210.2 0.0 1.5 2 0 0 2 2 2 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 AET38517.1 - 2e-23 82.2 1.7 8.8e-20 70.6 0.2 3.3 4 0 0 4 4 4 2 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 AET38517.1 - 1.7e-08 34.2 0.1 0.0072 16.2 0.1 2.7 2 0 0 2 2 2 2 TFIIE alpha subunit Rio2_N PF09202.11 AET38517.1 - 0.034 14.3 0.5 0.78 10.0 0.0 2.8 2 0 0 2 2 2 0 Rio2, N-terminal Peptidase_M16 PF00675.20 AET38518.1 - 1e-23 84.0 0.0 1.7e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 AET38518.1 - 3.3e-07 30.5 0.0 2.9e-06 27.4 0.0 2.3 2 1 0 2 2 2 1 Peptidase M16 inactive domain PTR2 PF00854.21 AET38519.1 - 9e-54 182.8 6.9 1.2e-53 182.3 6.9 1.1 1 0 0 1 1 1 1 POT family Fungal_trans_2 PF11951.8 AET38520.1 - 3.4e-11 42.6 2.0 6e-11 41.8 2.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET38520.1 - 3.4e-09 36.7 11.6 6.2e-09 35.8 11.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pyocin_S PF06958.12 AET38520.1 - 0.13 12.8 0.3 0.24 11.9 0.3 1.3 1 0 0 1 1 1 0 S-type Pyocin DUF917 PF06032.12 AET38521.1 - 3.1e-101 338.7 0.0 5.9e-101 337.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydant_A_N PF05378.13 AET38521.1 - 1.7e-30 106.1 2.2 1.6e-29 102.9 0.0 2.6 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.18 AET38521.1 - 1.1e-26 93.8 2.0 1.8e-22 79.9 1.9 3.2 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase MutL PF13941.6 AET38521.1 - 0.031 12.9 0.1 0.25 9.9 0.0 2.1 2 0 0 2 2 2 0 MutL protein StbA PF06406.11 AET38521.1 - 0.09 12.0 0.0 12 5.0 0.0 2.6 2 0 0 2 2 2 0 StbA protein RrnaAD PF00398.20 AET38522.1 - 1.1e-71 241.0 0.0 1.4e-71 240.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 AET38522.1 - 5.4e-08 33.4 0.0 2.1e-07 31.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AET38522.1 - 1.5e-05 25.5 0.0 4e-05 24.2 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain PCMT PF01135.19 AET38522.1 - 8.7e-05 22.4 0.0 0.00014 21.7 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 AET38522.1 - 0.00078 20.1 0.0 0.0018 19.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 AET38522.1 - 0.0022 17.4 0.0 0.0043 16.4 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Met_10 PF02475.16 AET38522.1 - 0.0036 17.1 0.0 0.006 16.4 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_2 PF00891.18 AET38522.1 - 0.0041 16.4 0.0 0.0072 15.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain PRMT5 PF05185.16 AET38522.1 - 0.0069 16.2 0.1 0.051 13.4 0.0 2.2 2 0 0 2 2 2 1 PRMT5 arginine-N-methyltransferase MTS PF05175.14 AET38522.1 - 0.014 15.0 0.0 0.026 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.6 AET38522.1 - 0.034 14.0 0.0 0.049 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_28 PF02636.17 AET38522.1 - 0.039 13.6 0.0 0.065 12.8 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_31 PF13847.6 AET38522.1 - 0.044 13.6 0.0 0.071 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 AET38522.1 - 0.061 13.3 0.0 4 7.4 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.18 AET38522.1 - 0.063 12.6 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family PI-PLC-X PF00388.19 AET38524.1 - 1.9e-49 167.0 0.0 3.8e-49 166.0 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 AET38524.1 - 1.1e-38 132.1 0.2 2.3e-38 131.1 0.2 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.11 AET38524.1 - 1.5e-06 28.6 0.1 1.1e-05 25.9 0.1 2.3 1 1 1 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_1 PF00036.32 AET38524.1 - 0.00026 20.3 0.1 0.00079 18.8 0.1 1.9 1 0 0 1 1 1 1 EF hand EF-hand_10 PF14788.6 AET38524.1 - 0.0008 19.2 0.4 0.0027 17.5 0.4 2.0 1 0 0 1 1 1 1 EF hand C2 PF00168.30 AET38524.1 - 0.0017 18.6 0.0 0.0077 16.5 0.0 2.2 3 0 0 3 3 2 1 C2 domain EF-hand_7 PF13499.6 AET38524.1 - 0.007 16.8 0.3 0.03 14.8 0.3 2.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 AET38524.1 - 0.016 15.1 0.3 0.016 15.1 0.3 2.3 2 0 0 2 2 2 0 EF-hand domain DUF1473 PF07341.11 AET38524.1 - 0.073 12.8 1.2 0.23 11.2 1.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1473) EF-hand_5 PF13202.6 AET38524.1 - 0.17 11.4 0.3 0.47 10.0 0.3 1.8 1 0 0 1 1 1 0 EF hand G6B PF15096.6 AET38524.1 - 0.19 11.5 0.0 0.49 10.2 0.0 1.7 2 0 0 2 2 2 0 G6B family KAR9 PF08580.10 AET38525.1 - 1.8e-101 340.8 24.2 3e-101 340.1 24.2 1.2 1 0 0 1 1 1 1 Yeast cortical protein KAR9 DUF948 PF06103.11 AET38525.1 - 2.1 8.6 10.3 16 5.9 1.0 4.3 4 2 0 4 4 4 0 Bacterial protein of unknown function (DUF948) ABC_membrane PF00664.23 AET38526.1 - 7.6e-56 189.8 4.5 1e-55 189.4 4.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 AET38526.1 - 1.4e-35 122.8 0.0 1.1e-34 119.9 0.0 2.5 3 0 0 3 3 3 1 ABC transporter SMC_N PF02463.19 AET38526.1 - 0.00043 19.8 0.0 0.032 13.7 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 AET38526.1 - 0.0032 17.2 0.1 0.014 15.2 0.1 2.1 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 AET38526.1 - 0.0047 16.7 0.0 0.019 14.7 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 AET38526.1 - 0.0065 16.2 0.0 0.24 11.1 0.0 3.1 2 1 1 3 3 3 1 IstB-like ATP binding protein AAA_5 PF07728.14 AET38526.1 - 0.011 15.7 0.6 0.079 13.0 0.0 2.7 3 1 1 4 4 4 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 AET38526.1 - 0.018 15.6 0.2 0.66 10.4 0.2 2.5 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 AET38526.1 - 0.026 14.8 0.0 0.25 11.6 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 AET38526.1 - 0.031 14.7 0.0 0.1 13.0 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 AET38526.1 - 0.05 13.1 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Peptidase_C58 PF03543.14 AET38526.1 - 0.15 11.7 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen ATP-synt_Eps PF04627.13 AET38527.1 - 8.8e-21 73.6 1.7 1e-20 73.4 1.7 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain DNA_pol_phi PF04931.13 AET38528.1 - 5.2e-210 699.4 12.2 6.4e-210 699.2 12.2 1.1 1 0 0 1 1 1 1 DNA polymerase phi PLN_propep PF16485.5 AET38530.1 - 0.013 15.2 0.3 0.026 14.2 0.3 1.5 1 0 0 1 1 1 0 Protealysin propeptide CAF1C_H4-bd PF12265.8 AET38531.1 - 3.9e-22 78.3 1.9 7.6e-22 77.4 0.5 2.2 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 AET38531.1 - 1.6e-17 63.5 1.5 3e-05 24.7 0.2 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET38531.1 - 0.012 15.9 0.1 9.6 6.6 0.0 3.9 2 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain PGM_PMM_I PF02878.16 AET38532.1 - 2e-16 60.0 0.0 5.1e-08 32.7 0.0 2.6 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 AET38532.1 - 7e-09 35.8 0.0 1.7e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 AET38532.1 - 0.004 17.7 0.1 0.018 15.6 0.1 2.2 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Mitochondr_Som1 PF11093.8 AET38533.1 - 6.8e-14 51.6 2.1 4.5e-13 49.0 2.1 1.9 1 1 0 1 1 1 1 Mitochondrial export protein Som1 Lyase_1 PF00206.20 AET38534.1 - 1.3e-114 382.8 0.0 2e-114 382.2 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 AET38534.1 - 6.7e-24 84.1 0.0 2.9e-23 82.0 0.0 2.2 2 0 0 2 2 2 1 Fumarase C C-terminus Peptidase_S8 PF00082.22 AET38535.1 - 4.2e-32 111.6 10.0 7.5e-32 110.8 9.8 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 AET38535.1 - 0.00071 20.2 0.0 0.0013 19.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 Fcf1 PF04900.12 AET38536.1 - 3.1e-34 117.3 1.0 5e-34 116.6 1.0 1.4 1 0 0 1 1 1 1 Fcf1 Kinesin PF00225.23 AET38537.1 - 6.4e-98 327.8 5.6 6.4e-98 327.8 5.6 3.5 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 AET38537.1 - 8.6e-19 67.9 0.0 8.6e-19 67.9 0.0 2.8 4 0 0 4 4 4 1 Microtubule binding NPR2 PF06218.11 AET38538.1 - 6.6e-137 456.9 9.9 2.5e-135 451.7 5.1 2.1 2 0 0 2 2 2 2 Nitrogen permease regulator 2 FlgT_M PF16539.5 AET38538.1 - 0.12 12.5 0.7 0.27 11.3 0.7 1.6 1 0 0 1 1 1 0 Flagellar assembly protein T, middle domain Ribo_biogen_C PF04034.13 AET38539.1 - 2.8e-51 172.5 0.0 4.1e-51 172.0 0.0 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 AET38539.1 - 1.2e-14 53.8 0.2 2.6e-14 52.7 0.2 1.6 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI VPS9 PF02204.18 AET38540.1 - 8.6e-18 64.5 0.5 7e-16 58.3 0.0 3.1 3 0 0 3 3 3 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.6 AET38540.1 - 7.5e-08 32.5 0.6 0.00091 19.5 0.0 3.9 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 AET38540.1 - 3.2e-06 27.6 0.6 0.011 16.4 0.1 3.3 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 AET38540.1 - 0.016 15.8 1.2 20 5.9 0.1 3.5 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 AET38540.1 - 0.11 13.2 4.0 48 5.0 0.0 4.7 5 0 0 5 5 5 0 Ankyrin repeat Ank PF00023.30 AET38540.1 - 0.15 12.6 0.1 1.7 9.2 0.0 2.8 3 0 0 3 3 3 0 Ankyrin repeat SGTA_dimer PF16546.5 AET38541.1 - 4.1e-20 71.3 1.3 7.8e-20 70.4 1.3 1.5 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_1 PF00515.28 AET38541.1 - 1.4e-16 59.5 10.9 1e-06 28.3 0.1 4.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 AET38541.1 - 8.2e-16 56.8 11.4 5.1e-05 23.1 0.1 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 AET38541.1 - 6.6e-15 54.5 2.8 8.8e-06 25.3 0.3 3.5 2 1 1 3 3 3 3 TPR repeat TPR_12 PF13424.6 AET38541.1 - 2.9e-08 33.9 1.0 0.01 16.1 0.0 3.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 AET38541.1 - 3.2e-08 33.1 11.0 0.00017 21.5 0.1 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 AET38541.1 - 1.7e-07 31.5 0.1 0.022 15.6 0.0 3.5 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 AET38541.1 - 3.2e-07 30.7 2.6 0.0096 16.4 0.0 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 AET38541.1 - 5.3e-07 29.6 0.2 0.0012 19.1 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 AET38541.1 - 7.8e-07 28.8 0.5 0.043 13.7 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 AET38541.1 - 1e-06 29.3 1.3 0.0022 18.6 0.2 2.5 1 1 0 2 2 2 2 Tetratricopeptide repeat BTAD PF03704.17 AET38541.1 - 5.2e-05 23.7 0.9 0.0042 17.5 0.1 2.4 1 1 1 2 2 2 1 Bacterial transcriptional activator domain STI1 PF17830.1 AET38541.1 - 0.00027 20.8 6.9 0.00027 20.8 6.9 2.2 2 0 0 2 2 2 1 STI1 domain TPR_6 PF13174.6 AET38541.1 - 0.00042 20.8 1.1 0.022 15.4 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 AET38541.1 - 0.0027 17.6 0.2 2.9 8.1 0.0 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 AET38541.1 - 0.0055 16.8 0.0 0.024 14.8 0.0 2.0 1 1 1 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 AET38541.1 - 0.61 10.2 8.9 1.5 8.9 0.0 4.1 4 2 1 5 5 5 0 MIT (microtubule interacting and transport) domain Alg6_Alg8 PF03155.15 AET38542.1 - 1.2e-140 469.7 28.7 1.6e-140 469.4 28.7 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Ras PF00071.22 AET38543.1 - 6.1e-58 195.0 0.2 7.2e-58 194.8 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET38543.1 - 4.6e-34 117.2 0.1 9.1e-34 116.2 0.1 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET38543.1 - 2.5e-15 56.4 0.0 2.9e-15 56.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AET38543.1 - 4.5e-08 32.7 0.0 5.5e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AET38543.1 - 1.6e-06 28.2 0.0 3.3e-06 27.2 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AET38543.1 - 2.5e-06 27.2 0.2 0.00014 21.5 0.2 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 AET38543.1 - 4.7e-05 22.9 0.0 6.4e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 AET38543.1 - 0.00014 21.8 0.1 0.034 14.1 0.0 2.4 1 1 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 AET38543.1 - 0.0027 18.0 0.0 0.0044 17.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 AET38543.1 - 0.0056 16.6 0.1 0.023 14.6 0.0 1.9 2 0 0 2 2 2 1 NTPase cobW PF02492.19 AET38543.1 - 0.0059 16.2 0.0 0.018 14.6 0.0 1.7 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 AET38543.1 - 0.0068 16.8 0.0 0.011 16.1 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 AET38543.1 - 0.014 14.8 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.9 AET38543.1 - 0.017 14.9 0.3 0.075 12.8 0.1 2.0 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 AET38543.1 - 0.02 14.8 0.0 0.047 13.6 0.0 1.6 2 0 0 2 2 2 0 NACHT domain AAA_7 PF12775.7 AET38543.1 - 0.03 13.9 0.1 0.044 13.3 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 AET38543.1 - 0.033 13.9 0.1 0.089 12.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 AET38543.1 - 0.034 13.4 0.1 0.35 10.1 0.0 2.1 2 0 0 2 2 2 0 Septin AAA_33 PF13671.6 AET38543.1 - 0.068 13.3 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 AET38543.1 - 0.14 11.3 0.1 0.53 9.4 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain AAA_5 PF07728.14 AET38543.1 - 0.18 11.8 0.0 0.5 10.4 0.0 1.8 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Cyclin PF08613.11 AET38544.1 - 3.4e-35 121.8 1.0 3.4e-35 121.8 1.0 1.9 2 1 1 3 3 3 1 Cyclin Cyclin_N PF00134.23 AET38544.1 - 0.00092 19.0 0.1 0.0015 18.3 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain DNA_pol_A_exo1 PF01612.20 AET38545.1 - 1.1e-46 158.7 1.7 1.8e-46 158.1 0.1 2.0 2 0 0 2 2 2 1 3'-5' exonuclease PMC2NT PF08066.12 AET38545.1 - 2.9e-19 69.5 1.9 2.9e-19 69.5 1.9 3.4 4 1 0 4 4 4 1 PMC2NT (NUC016) domain HRDC PF00570.23 AET38545.1 - 2.2e-10 40.3 0.0 4.6e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 HRDC domain HlyIII PF03006.20 AET38546.1 - 2.6e-53 181.0 20.1 3.1e-53 180.8 20.1 1.1 1 0 0 1 1 1 1 Haemolysin-III related SdpI PF13630.6 AET38546.1 - 2.4 8.4 0.0 2.4 8.4 0.0 4.0 1 1 0 2 2 2 0 SdpI/YhfL protein family DUF2964 PF11177.8 AET38546.1 - 3.7 7.8 6.6 34 4.7 0.1 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2964) DHHC PF01529.20 AET38547.1 - 1e-27 96.8 15.3 1e-27 96.8 15.3 1.6 2 0 0 2 2 2 1 DHHC palmitoyltransferase Sin3a_C PF16879.5 AET38548.1 - 8.1e-77 258.7 7.3 8.1e-77 258.7 7.3 3.2 3 0 0 3 3 3 1 C-terminal domain of Sin3a protein PAH PF02671.21 AET38548.1 - 7.4e-49 163.7 8.8 7.4e-18 64.4 2.1 4.2 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 AET38548.1 - 4.3e-43 145.4 0.2 2.5e-42 142.9 0.1 2.5 2 0 0 2 2 2 1 Sin3 family co-repressor PRD PF00874.20 AET38548.1 - 0.16 12.3 1.9 1.1 9.7 0.4 3.1 2 1 0 2 2 2 0 PRD domain UMP1 PF05348.11 AET38548.1 - 8.5 6.6 9.5 5.5 7.2 6.6 2.2 2 0 0 2 2 2 0 Proteasome maturation factor UMP1 Pkinase PF00069.25 AET38549.1 - 3.9e-76 255.9 0.0 6.4e-76 255.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38549.1 - 2.8e-39 135.0 0.0 4.3e-39 134.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 AET38549.1 - 4.5e-27 94.0 0.1 1.6e-13 50.6 0.0 2.7 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 AET38549.1 - 5.2e-11 42.4 0.0 7.2e-10 38.7 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 AET38549.1 - 0.0016 17.3 0.1 0.0025 16.7 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 AET38549.1 - 0.002 17.5 0.2 0.0056 16.1 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family SH3_3 PF08239.11 AET38549.1 - 0.0045 17.2 0.1 0.0087 16.3 0.1 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain Haspin_kinase PF12330.8 AET38549.1 - 0.035 13.1 0.1 0.093 11.7 0.1 1.6 1 1 0 1 1 1 0 Haspin like kinase domain Peptidase_A21 PF03566.13 AET38549.1 - 0.096 10.9 0.5 0.14 10.4 0.5 1.1 1 0 0 1 1 1 0 Peptidase family A21 Topoisom_I_N PF02919.15 AET38550.1 - 1.2e-96 322.3 0.1 1.2e-96 322.3 0.1 2.5 2 1 0 2 2 2 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.20 AET38550.1 - 2.1e-96 321.7 0.5 2.1e-96 321.7 0.5 2.7 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.6 AET38550.1 - 1e-30 105.5 0.9 2.6e-30 104.1 0.9 1.8 1 0 0 1 1 1 1 C-terminal topoisomerase domain Carot_N PF09150.10 AET38550.1 - 0.065 13.1 0.2 0.16 11.9 0.2 1.6 1 0 0 1 1 1 0 Orange carotenoid protein, N-terminal CHCH PF06747.13 AET38552.1 - 1e-05 25.5 3.7 1.5e-05 25.0 3.7 1.3 1 0 0 1 1 1 1 CHCH domain DUF2076 PF09849.9 AET38552.1 - 3.1e-05 24.2 7.5 3.7e-05 23.9 7.5 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CX9C PF16860.5 AET38552.1 - 0.0043 17.0 2.9 0.0071 16.3 2.9 1.3 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, SAP PF02037.27 AET38553.1 - 3.5e-10 39.4 0.0 5.8e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 SAP domain Polyketide_cyc PF03364.20 AET38554.1 - 7.7e-15 55.3 0.0 9.7e-15 54.9 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport MMM1 PF10296.9 AET38555.1 - 6.1e-12 45.2 0.2 7.7e-12 44.9 0.2 1.1 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 PX PF00787.24 AET38556.1 - 5.1e-20 71.6 0.1 1.4e-19 70.1 0.1 1.8 1 0 0 1 1 1 1 PX domain Latarcin PF10279.9 AET38556.1 - 2.5 8.5 5.4 14 6.2 0.9 3.0 3 0 0 3 3 3 0 Latarcin precursor RTC PF01137.21 AET38557.1 - 1.2e-44 152.2 0.0 1.4e-44 152.0 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 AET38557.1 - 3.1e-31 107.9 0.0 5.1e-31 107.3 0.0 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain TAF4 PF05236.14 AET38558.1 - 2.7e-53 181.5 7.8 2.7e-53 181.5 7.8 2.4 2 1 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family Suf PF05843.14 AET38558.1 - 0.17 11.8 2.7 0.26 11.2 2.7 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Histone PF00125.24 AET38559.1 - 2.2e-16 60.4 0.0 2.8e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 AET38559.1 - 5.1e-14 51.7 0.3 8.3e-14 51.0 0.3 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 AET38559.1 - 9.6e-05 22.6 0.0 0.00013 22.2 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone OPA3 PF07047.12 AET38560.1 - 1.3e-41 141.3 0.8 1.5e-41 141.1 0.8 1.0 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) NYD-SP28_assoc PF14775.6 AET38560.1 - 0.009 16.1 0.7 0.009 16.1 0.7 2.1 2 0 0 2 2 2 1 Sperm tail C-terminal domain THOC7 PF05615.13 AET38560.1 - 0.045 14.0 4.1 0.78 10.0 0.3 2.1 2 0 0 2 2 2 0 Tho complex subunit 7 HAUS5 PF14817.6 AET38560.1 - 0.06 12.1 4.0 0.05 12.4 2.7 1.5 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 5 SLATT_1 PF18181.1 AET38560.1 - 0.079 12.9 0.2 0.39 10.7 0.0 1.9 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 HBS1_N PF08938.10 AET38560.1 - 0.16 12.3 0.5 0.33 11.3 0.3 1.7 1 1 1 2 2 2 0 HBS1 N-terminus ABC_tran_CTD PF16326.5 AET38560.1 - 0.26 11.6 3.9 0.33 11.2 2.2 1.9 2 0 0 2 2 2 0 ABC transporter C-terminal domain zf-RING_2 PF13639.6 AET38561.1 - 6.4e-11 42.4 4.7 1.5e-10 41.2 4.7 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 AET38561.1 - 1.2e-07 31.9 5.2 4.6e-07 30.0 5.2 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 AET38561.1 - 1.7e-07 31.0 2.7 4.2e-07 29.7 2.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AET38561.1 - 6.3e-06 25.9 3.2 1.7e-05 24.6 3.2 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 AET38561.1 - 7e-06 25.8 5.4 7e-06 25.8 5.4 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AET38561.1 - 1.6e-05 24.8 3.6 1.6e-05 24.8 3.6 2.0 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 AET38561.1 - 5.1e-05 23.2 1.7 5.1e-05 23.2 1.7 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_11 PF17123.5 AET38561.1 - 5.7e-05 22.8 1.1 0.0005 19.8 1.1 2.5 1 1 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 AET38561.1 - 0.00056 19.7 9.5 0.00056 19.7 9.5 2.3 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 AET38561.1 - 0.011 15.4 2.1 0.026 14.2 2.1 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 AET38561.1 - 0.014 15.5 2.6 0.047 13.9 2.6 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain Pox_A_type_inc PF04508.12 AET38561.1 - 0.017 15.0 3.8 0.04 13.8 3.8 1.7 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat zf-ANAPC11 PF12861.7 AET38561.1 - 0.018 15.1 2.1 0.077 13.1 2.1 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Rtf2 PF04641.12 AET38561.1 - 0.33 10.3 23.3 0.014 14.8 3.7 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger RINGv PF12906.7 AET38561.1 - 0.84 9.8 3.6 2.8 8.1 3.6 1.9 1 1 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 AET38561.1 - 1.2 9.0 4.3 2.4 8.0 4.3 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain eIF-3_zeta PF05091.12 AET38561.1 - 1.9 7.3 34.7 0.67 8.9 8.7 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF1764 PF08576.10 AET38561.1 - 2.2 9.2 20.1 1.4 9.8 5.5 2.7 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) SpoIIP PF07454.11 AET38561.1 - 8.2 5.8 26.6 5.6 6.3 11.0 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF702 PF05142.12 AET38561.1 - 9.1 6.8 22.1 1.6 9.2 4.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF702) RNA_pol_I_TF PF04090.12 AET38562.1 - 9.7e-66 221.1 0.7 1.7e-65 220.3 0.7 1.4 1 0 0 1 1 1 1 RNA polymerase I specific initiation factor La PF05383.17 AET38563.1 - 2.7e-15 56.1 0.2 5.2e-15 55.2 0.2 1.4 1 0 0 1 1 1 1 La domain ABC1 PF03109.16 AET38564.1 - 1.3e-34 118.9 0.0 2.6e-34 117.9 0.0 1.6 1 0 0 1 1 1 1 ABC1 family Abhydrolase_8 PF06259.12 AET38564.1 - 0.027 14.1 0.1 0.045 13.4 0.1 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase OB_NTP_bind PF07717.16 AET38565.1 - 1.1e-22 80.2 0.0 2.9e-22 78.8 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 AET38565.1 - 1.6e-21 76.6 0.0 4.3e-21 75.2 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 AET38565.1 - 8.6e-12 45.4 0.0 3.1e-11 43.6 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 AET38565.1 - 3.1e-09 36.8 0.2 7.9e-09 35.5 0.1 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AET38565.1 - 3.3e-07 30.6 0.3 1.1e-06 28.9 0.1 2.0 2 0 0 2 2 1 1 AAA domain Flavi_DEAD PF07652.14 AET38565.1 - 0.00013 21.9 0.1 0.00033 20.7 0.1 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_19 PF13245.6 AET38565.1 - 0.00023 21.5 0.1 0.00045 20.6 0.1 1.4 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 AET38565.1 - 0.00029 20.5 0.2 0.00077 19.1 0.2 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_30 PF13604.6 AET38565.1 - 0.00038 20.2 0.0 0.00072 19.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 AET38565.1 - 0.0057 17.2 0.0 0.024 15.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 AET38565.1 - 0.0078 16.2 0.2 0.46 10.5 0.2 2.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_7 PF12775.7 AET38565.1 - 0.028 13.9 0.0 0.17 11.4 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region T2SSE PF00437.20 AET38565.1 - 0.047 12.7 0.0 0.097 11.7 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2075 PF09848.9 AET38565.1 - 0.065 12.5 0.0 0.095 11.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.22 AET38565.1 - 0.089 12.0 0.0 1.1 8.4 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain IstB_IS21 PF01695.17 AET38565.1 - 0.12 12.1 0.1 3.1 7.5 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein LSM PF01423.22 AET38566.1 - 0.066 12.9 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 LSM domain Nab2 PF11517.8 AET38567.1 - 8.8e-45 151.2 0.8 1.4e-44 150.5 0.8 1.3 1 0 0 1 1 1 1 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) Nab2p_Zf1 PF18260.1 AET38567.1 - 2.3e-16 59.4 8.5 2.3e-16 59.4 8.5 2.8 2 0 0 2 2 2 1 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 zf-CCCH_2 PF14608.6 AET38567.1 - 4e-15 55.7 67.0 3.1e-05 24.3 4.1 6.7 7 0 0 7 7 7 6 RNA-binding, Nab2-type zinc finger Imm19 PF15563.6 AET38567.1 - 0.22 11.0 0.0 0.31 10.5 0.0 1.2 1 0 0 1 1 1 0 Immunity protein 19 Ribosomal_S5 PF00333.20 AET38568.1 - 7.4e-27 93.1 3.9 4.6e-26 90.6 2.7 2.4 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 AET38568.1 - 2.9e-22 77.9 0.0 4.9e-22 77.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain CoA_binding_3 PF13727.6 AET38568.1 - 0.16 11.9 0.0 0.61 10.1 0.0 1.8 1 1 1 2 2 2 0 CoA-binding domain DUF5353 PF17304.2 AET38569.1 - 0.0016 18.1 0.4 0.0032 17.2 0.4 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5353) DUF883 PF05957.13 AET38569.1 - 0.14 12.8 2.6 0.94 10.1 2.6 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) SLD3 PF08639.10 AET38569.1 - 0.28 9.9 2.0 0.34 9.6 2.0 1.1 1 0 0 1 1 1 0 DNA replication regulator SLD3 YtxH PF12732.7 AET38569.1 - 0.61 10.7 7.0 26 5.5 7.0 2.5 1 1 0 1 1 1 0 YtxH-like protein Mon1 PF03164.14 AET38570.1 - 6.4e-138 460.2 0.9 8.4e-138 459.8 0.9 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 GATA PF00320.27 AET38571.1 - 2.8e-10 39.6 4.1 2.8e-10 39.6 4.1 1.8 2 0 0 2 2 2 1 GATA zinc finger Zn_peptidase_2 PF04298.12 AET38571.1 - 0.13 11.6 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase Glyco_hydro_31 PF01055.26 AET38572.1 - 9.6e-130 433.7 1.6 1.6e-129 433.0 1.6 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 AET38572.1 - 1.5e-23 82.9 4.1 2.1e-23 82.4 0.5 2.9 3 0 0 3 3 3 1 Galactose mutarotase-like DUF5110 PF17137.4 AET38572.1 - 4.8e-08 33.2 0.2 4.8e-08 33.2 0.2 2.8 4 0 0 4 4 4 1 Domain of unknown function (DUF5110) GIY-YIG PF01541.24 AET38573.1 - 1.3e-11 44.6 0.4 3.1e-11 43.4 0.0 1.8 2 0 0 2 2 2 1 GIY-YIG catalytic domain WASH_WAHD PF11945.8 AET38573.1 - 0.032 13.7 0.0 0.06 12.9 0.0 1.3 1 0 0 1 1 1 0 WAHD domain of WASH complex C1_2 PF03107.16 AET38573.1 - 2 8.8 8.4 0.63 10.4 5.1 1.9 2 0 0 2 2 2 0 C1 domain Methyltransf_11 PF08241.12 AET38574.1 - 0.00021 21.9 0.0 0.00044 20.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AET38574.1 - 0.067 13.9 0.0 0.15 12.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MTHFR PF02219.17 AET38575.1 - 1.6e-116 388.7 0.0 2.2e-116 388.2 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Tyr-DNA_phospho PF06087.12 AET38576.1 - 4.6e-85 286.1 0.0 5.9e-85 285.7 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase AMP-binding PF00501.28 AET38577.1 - 8.4e-77 258.5 0.0 1e-76 258.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AET38577.1 - 4.3e-15 56.5 0.3 1e-14 55.2 0.3 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain RTX_C PF08339.10 AET38577.1 - 0.027 14.6 0.0 0.058 13.5 0.0 1.5 1 0 0 1 1 1 0 RTX C-terminal domain Transket_pyr PF02779.24 AET38578.1 - 1.2e-46 158.6 0.1 2.1e-46 157.8 0.1 1.4 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 AET38578.1 - 1.1e-35 122.2 0.0 2.2e-35 121.2 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain Acatn PF13000.7 AET38579.1 - 2.7e-262 871.2 18.8 3.1e-262 871.0 18.8 1.0 1 0 0 1 1 1 1 Acetyl-coenzyme A transporter 1 Scs3p PF10261.9 AET38580.1 - 1.9e-69 233.9 9.4 2.5e-69 233.5 9.4 1.1 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Med31 PF05669.12 AET38581.1 - 2.5e-25 88.3 1.7 2.9e-25 88.1 1.7 1.1 1 0 0 1 1 1 1 SOH1 MF_alpha_N PF05436.11 AET38582.1 - 5.2e-27 93.6 0.5 6.5e-27 93.3 0.5 1.1 1 0 0 1 1 1 1 Mating factor alpha precursor N-terminus MF_alpha PF04648.12 AET38582.1 - 1.2e-22 79.3 23.1 7.2e-08 32.4 3.0 3.2 3 0 0 3 3 3 3 Yeast mating factor alpha hormone Vac_ImportDeg PF09783.9 AET38582.1 - 0.15 11.9 2.7 14 5.5 3.1 2.7 1 1 1 2 2 2 0 Vacuolar import and degradation protein Cytochrome_P460 PF16694.5 AET38582.1 - 2.5 8.5 6.2 11 6.4 0.2 2.9 1 1 2 3 3 3 0 Cytochrome P460 CPSase_L_D2 PF02786.17 AET38583.1 - 1.9e-83 279.1 0.2 3e-83 278.5 0.2 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 AET38583.1 - 2.8e-68 229.6 0.0 5.4e-68 228.6 0.0 1.5 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 AET38583.1 - 4.2e-39 133.5 0.1 7.9e-39 132.6 0.1 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 AET38583.1 - 1.4e-29 102.3 0.0 3.9e-29 100.9 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 AET38583.1 - 5e-26 91.8 0.0 8.8e-26 91.0 0.0 1.4 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 AET38583.1 - 7e-19 67.4 3.5 7e-19 67.4 3.5 2.2 3 0 0 3 3 3 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 AET38583.1 - 8.5e-07 28.7 0.0 1.8e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 AET38583.1 - 2.1e-06 27.5 3.5 0.0041 16.9 0.3 2.6 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp PF02222.22 AET38583.1 - 1.5e-05 24.7 0.0 3e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 AET38583.1 - 2.4e-05 23.7 0.7 0.0027 17.0 0.1 2.4 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATP-grasp_3 PF02655.14 AET38583.1 - 0.00015 21.8 0.2 0.00051 20.1 0.0 2.0 2 1 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 AET38583.1 - 0.00058 19.7 0.0 0.0055 16.5 0.0 2.2 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_ST PF14397.6 AET38583.1 - 0.0017 17.7 0.0 0.0036 16.6 0.0 1.5 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp HlyD_3 PF13437.6 AET38583.1 - 0.0093 16.7 1.6 4.2 8.1 0.1 3.0 2 0 0 2 2 2 1 HlyD family secretion protein ATP-grasp_4 PF13535.6 AET38583.1 - 0.03 13.9 0.0 0.062 12.9 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain RnfC_N PF13375.6 AET38583.1 - 0.23 11.5 1.2 4.9 7.2 0.6 2.6 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain DASH_Duo1 PF08651.10 AET38584.1 - 8.6e-24 83.1 1.4 1.9e-23 82.0 1.4 1.6 1 0 0 1 1 1 1 DASH complex subunit Duo1 DASH_Dad2 PF08654.10 AET38584.1 - 0.026 15.0 1.5 0.06 13.8 1.5 1.6 1 1 0 1 1 1 0 DASH complex subunit Dad2 LRRC37AB_C PF14914.6 AET38584.1 - 0.033 14.1 1.9 0.049 13.5 1.9 1.2 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain STN1_2 PF09170.10 AET38584.1 - 0.061 13.5 0.6 0.15 12.3 0.4 1.7 1 1 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 FlgN PF05130.12 AET38584.1 - 0.54 10.7 3.5 1.4 9.4 0.1 2.1 1 1 1 2 2 2 0 FlgN protein GA PF01468.17 AET38584.1 - 0.78 10.1 6.3 18 5.7 0.0 3.1 3 0 0 3 3 3 0 GA module APG12 PF04110.13 AET38585.1 - 1.5e-26 92.6 0.0 2.5e-26 91.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Kinetochor_Ybp2 PF08568.10 AET38586.1 - 7.3e-125 417.9 13.4 8.7e-125 417.6 13.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin Mei4 PF13971.6 AET38586.1 - 0.0077 15.8 0.2 0.0077 15.8 0.2 2.2 2 0 0 2 2 2 1 Meiosis-specific protein Mei4 TBK1_CCD1 PF18394.1 AET38586.1 - 0.2 11.2 5.3 0.052 13.1 1.1 2.0 2 0 0 2 2 2 0 TANK-binding kinase 1 coiled-coil domain 1 HUN PF08729.10 AET38587.1 - 2.8e-07 30.4 0.0 2.8e-07 30.4 0.0 2.3 2 0 0 2 2 2 1 HPC2 and ubinuclein domain CENP-B_dimeris PF09026.10 AET38587.1 - 3.6 8.0 9.6 8.8 6.8 9.6 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain BCDHK_Adom3 PF10436.9 AET38588.1 - 5.4e-31 107.6 0.8 9.5e-31 106.8 0.8 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 AET38588.1 - 4.5e-05 23.9 0.1 0.22 12.0 0.0 2.7 3 0 0 3 3 3 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 AET38588.1 - 0.053 13.3 0.0 0.15 11.9 0.0 1.8 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase UQ_con PF00179.26 AET38589.1 - 4.2e-51 172.3 0.1 4.9e-51 172.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AET38589.1 - 0.011 15.4 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 AET38589.1 - 0.032 14.5 0.1 0.077 13.3 0.1 1.7 1 1 0 1 1 1 0 RWD domain UEV PF05743.13 AET38589.1 - 0.064 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 UEV domain Leuk-A4-hydro_C PF09127.11 AET38589.1 - 0.067 13.3 0.1 0.92 9.6 0.1 2.1 1 1 0 1 1 1 0 Leukotriene A4 hydrolase, C-terminal COX4 PF02936.14 AET38590.1 - 0.049 13.7 0.0 0.085 12.9 0.0 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV CBS PF00571.28 AET38591.1 - 1.9e-20 73.1 2.5 0.00053 20.4 0.1 5.3 5 0 0 5 5 5 5 CBS domain ASCH PF04266.14 AET38591.1 - 0.095 13.3 0.0 3.6 8.2 0.0 2.9 3 0 0 3 3 3 0 ASCH domain Pro-rich_19 PF15455.6 AET38591.1 - 0.12 11.5 2.5 0.22 10.6 2.5 1.3 1 0 0 1 1 1 0 Proline-rich 19 FA_desaturase PF00487.24 AET38592.1 - 8.4e-19 68.4 23.9 8.4e-19 68.4 23.9 1.9 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 AET38592.1 - 1.8e-15 56.8 0.0 4.1e-15 55.7 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_7 PF13241.6 AET38593.1 - 1.8e-26 92.6 0.0 3.7e-26 91.6 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.6 AET38593.1 - 1.5e-11 43.5 0.2 3.6e-11 42.3 0.2 1.6 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Sirohm_synth_C PF14823.6 AET38593.1 - 5.1e-11 42.1 0.2 9.5e-11 41.2 0.2 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal ThiF PF00899.21 AET38593.1 - 0.0093 15.3 0.0 0.026 13.9 0.0 1.6 2 0 0 2 2 2 1 ThiF family 2-Hacid_dh_C PF02826.19 AET38593.1 - 0.16 11.3 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 AET38593.1 - 0.23 11.5 0.0 0.58 10.2 0.0 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase RRM_1 PF00076.22 AET38594.1 - 4.5e-40 135.3 0.0 1.1e-16 60.4 0.0 4.2 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AET38594.1 - 0.00072 19.4 0.1 0.19 11.6 0.0 2.8 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.5 AET38594.1 - 0.0055 16.8 0.0 0.041 14.0 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif Nup35_RRM_2 PF14605.6 AET38594.1 - 0.071 13.1 0.0 0.3 11.1 0.0 2.0 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 AET38594.1 - 0.092 12.8 0.0 0.092 12.8 0.0 2.8 4 0 0 4 4 4 0 RNA binding motif BEX PF04538.12 AET38595.1 - 0.11 13.1 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 Brain expressed X-linked like family Cornichon PF03311.14 AET38596.1 - 1.8e-46 157.4 9.7 2e-46 157.3 9.7 1.0 1 0 0 1 1 1 1 Cornichon protein SNF2_N PF00176.23 AET38597.1 - 8.1e-55 185.9 4.3 1e-54 185.6 0.1 2.5 2 1 1 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AET38597.1 - 1.1e-15 57.9 0.0 3.8e-15 56.2 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 AET38597.1 - 6e-06 26.1 2.5 1.4e-05 24.9 2.5 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 AET38597.1 - 2.4e-05 24.3 2.6 6e-05 23.0 2.6 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 AET38597.1 - 0.00026 20.8 1.1 0.00026 20.8 1.1 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AET38597.1 - 0.00036 20.3 2.7 0.00082 19.2 2.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AET38597.1 - 0.00038 20.7 3.1 0.00095 19.5 3.1 1.8 1 0 0 1 1 1 1 Ring finger domain ResIII PF04851.15 AET38597.1 - 0.0027 17.7 3.0 0.0039 17.2 0.1 2.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-C3HC4_2 PF13923.6 AET38597.1 - 0.0069 16.2 3.9 0.024 14.5 3.9 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AET38597.1 - 0.096 12.6 8.0 0.026 14.4 4.4 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Patched PF02460.18 AET38597.1 - 0.15 10.1 0.4 0.29 9.1 0.4 1.4 1 0 0 1 1 1 0 Patched family Cellulase PF00150.18 AET38598.1 - 4.4e-12 46.0 0.0 9.1e-12 45.0 0.0 1.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) INO80_Ies4 PF08193.11 AET38599.1 - 0.045 13.7 2.4 0.045 13.7 2.4 2.8 1 1 2 3 3 3 0 INO80 complex subunit Ies4 Tic110 PF16940.5 AET38599.1 - 0.61 8.5 1.8 0.64 8.4 1.8 1.0 1 0 0 1 1 1 0 Chloroplast envelope transporter Pax7 PF12360.8 AET38599.1 - 0.92 9.8 9.6 5.7 7.2 0.3 2.6 2 0 0 2 2 2 0 Paired box protein 7 DUF1708 PF08101.11 AET38600.1 - 1.7e-128 429.4 0.7 1.2e-126 423.4 0.7 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF1708) G_glu_transpept PF01019.21 AET38601.1 - 1.5e-144 482.6 0.0 1.9e-144 482.3 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase GTP_EFTU PF00009.27 AET38602.1 - 2.2e-59 200.3 0.5 2.9e-59 199.9 0.5 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 AET38602.1 - 3e-27 95.1 0.0 5.8e-27 94.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 AET38602.1 - 1.3e-20 73.6 0.9 3.2e-20 72.3 0.9 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AET38602.1 - 2.5e-05 24.3 0.1 6.5e-05 23.0 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 AET38602.1 - 0.011 15.4 0.4 3.5 7.4 0.1 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 AET38602.1 - 0.014 15.3 0.1 0.043 13.7 0.0 1.8 1 1 1 2 2 2 0 RsgA GTPase V-set_2 PF15910.5 AET38602.1 - 0.022 14.9 0.0 0.05 13.7 0.0 1.5 1 0 0 1 1 1 0 ICOS V-set domain cobW PF02492.19 AET38602.1 - 0.048 13.3 1.3 0.058 13.0 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Peptidase_U32_C PF16325.5 AET38602.1 - 0.058 13.7 0.3 0.22 11.8 0.1 2.0 2 0 0 2 2 2 0 Peptidase family U32 C-terminal domain zf-U1 PF06220.12 AET38603.1 - 3.8e-18 64.9 5.7 8.5e-18 63.8 5.7 1.6 1 0 0 1 1 1 1 U1 zinc finger ALMS_repeat PF18727.1 AET38603.1 - 0.087 12.7 0.9 0.22 11.5 0.2 2.1 2 1 0 2 2 2 0 Alstrom syndrome repeat ATP_sub_h PF10775.9 AET38604.1 - 1.9e-23 82.2 0.0 2.6e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase complex subunit h Angiomotin_C PF12240.8 AET38605.1 - 0.00011 21.8 0.6 0.00019 21.1 0.2 1.6 2 0 0 2 2 2 1 Angiomotin C terminal ADIP PF11559.8 AET38605.1 - 0.00095 19.3 0.1 0.00095 19.3 0.1 2.1 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding SlyX PF04102.12 AET38605.1 - 5 7.8 8.2 15 6.3 2.4 2.8 2 0 0 2 2 2 0 SlyX Ras PF00071.22 AET38606.1 - 1.2e-50 171.3 0.0 1.5e-50 171.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET38606.1 - 1e-30 106.4 0.1 2.7e-30 105.1 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET38606.1 - 2.1e-11 43.6 0.0 2.9e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AET38606.1 - 0.00075 19.6 0.0 0.0016 18.5 0.0 1.5 1 1 1 2 2 2 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 AET38606.1 - 0.00098 19.5 0.1 0.0065 16.8 0.1 2.1 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.12 AET38606.1 - 0.0015 17.9 0.0 0.0021 17.4 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 AET38606.1 - 0.017 14.6 0.0 0.029 13.8 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Pox_A32 PF04665.12 AET38606.1 - 0.019 14.4 0.1 0.036 13.5 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein G-alpha PF00503.20 AET38606.1 - 0.02 14.0 2.3 2.1 7.4 0.1 2.8 2 1 1 3 3 3 0 G-protein alpha subunit GTP_EFTU PF00009.27 AET38606.1 - 0.024 14.2 0.5 0.11 12.0 0.0 2.0 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AET38606.1 - 0.024 14.5 0.1 8.2 6.3 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase ATPase PF06745.13 AET38606.1 - 0.026 13.9 0.2 0.041 13.2 0.2 1.2 1 0 0 1 1 1 0 KaiC AAA_7 PF12775.7 AET38606.1 - 0.032 13.7 0.0 0.055 13.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 AET38606.1 - 0.054 13.2 0.1 0.09 12.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 AET38606.1 - 0.091 12.8 0.1 0.21 11.6 0.1 1.6 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 AET38606.1 - 0.097 12.8 0.2 0.22 11.7 0.2 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 AET38606.1 - 0.13 12.7 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 AET38606.1 - 0.14 11.4 0.3 0.27 10.5 0.0 1.6 2 0 0 2 2 2 0 Septin IF-2B PF01008.17 AET38607.1 - 4.5e-81 272.1 0.6 1.4e-80 270.6 0.6 1.7 1 1 0 1 1 1 1 Initiation factor 2 subunit family DUF4795 PF16043.5 AET38607.1 - 0.083 12.5 0.7 0.22 11.1 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Amj PF10997.8 AET38607.1 - 0.14 11.5 0.1 0.25 10.6 0.1 1.3 1 0 0 1 1 1 0 Alternate to MurJ NAD_binding_10 PF13460.6 AET38608.1 - 5.1e-06 26.5 0.0 3e-05 24.0 0.0 2.1 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 AET38608.1 - 0.0001 21.5 0.0 0.0002 20.4 0.0 1.5 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 AET38608.1 - 0.0037 16.7 0.0 0.0059 16.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 AET38608.1 - 0.016 15.2 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 KR domain GTP_EFTU PF00009.27 AET38609.1 - 1.1e-47 162.1 0.0 2.2e-47 161.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 AET38609.1 - 3.7e-41 139.6 6.6 6.5e-41 138.8 6.6 1.4 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 AET38609.1 - 2.6e-18 65.8 0.0 6.8e-18 64.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 AET38609.1 - 7.5e-06 26.0 0.2 5.1e-05 23.3 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 AET38609.1 - 3.6e-05 24.1 0.2 9.3e-05 22.7 0.2 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ras PF00071.22 AET38609.1 - 0.0011 18.6 0.0 0.0025 17.4 0.0 1.5 1 0 0 1 1 1 1 Ras family RF3_C PF16658.5 AET38609.1 - 0.0081 16.0 0.0 0.051 13.4 0.0 2.1 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain SRPRB PF09439.10 AET38609.1 - 0.029 13.8 0.0 0.082 12.3 0.0 1.8 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit DUF1931 PF09123.11 AET38609.1 - 0.038 14.1 0.4 0.78 9.9 0.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1931) EFG_II PF14492.6 AET38609.1 - 0.044 13.9 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 Elongation Factor G, domain II Roc PF08477.13 AET38609.1 - 0.11 12.7 0.0 1.8 8.8 0.0 2.5 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Hus1 PF04005.12 AET38610.1 - 4.8e-26 91.5 0.1 9.6e-26 90.6 0.1 1.4 1 1 0 1 1 1 1 Hus1-like protein Aminotran_5 PF00266.19 AET38611.1 - 2.9e-34 118.6 0.0 3.6e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Ribosomal_S30 PF04758.14 AET38612.1 - 7.6e-30 102.9 6.6 8.3e-30 102.8 6.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 GCIP PF13324.6 AET38613.1 - 1.6e-37 129.5 3.1 1.9e-37 129.3 3.1 1.1 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting DASH_Dad4 PF08650.10 AET38613.1 - 0.065 13.2 5.6 3.8 7.6 0.4 3.9 4 0 0 4 4 4 0 DASH complex subunit Dad4 WH1 PF00568.23 AET38614.1 - 1.7e-31 108.4 0.0 2.5e-31 107.9 0.0 1.2 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.20 AET38614.1 - 0.00025 20.8 1.6 0.0018 18.1 0.7 2.4 2 0 0 2 2 2 1 WH2 motif Glyco_hydro_18 PF00704.28 AET38615.1 - 1.7e-26 93.7 0.1 1.3e-25 90.8 0.1 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 AET38615.1 - 6.1e-06 26.1 5.2 6.1e-06 26.1 5.2 3.2 2 0 0 2 2 2 1 Carbohydrate binding domain (family 19) Mitofilin PF09731.9 AET38615.1 - 0.8 8.5 5.0 1.4 7.7 5.0 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Methyltransf_16 PF10294.9 AET38616.1 - 1.3e-11 44.5 0.0 1.3e-10 41.3 0.0 2.0 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 AET38616.1 - 0.00023 21.0 0.0 0.00035 20.5 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AET38616.1 - 0.094 13.4 0.0 0.19 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain ECH_1 PF00378.20 AET38617.1 - 1.1e-16 60.9 0.0 1.7e-16 60.3 0.0 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 AET38617.1 - 2.7e-08 33.7 0.0 3.5e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Syndecan PF01034.20 AET38617.1 - 0.047 13.6 0.0 0.099 12.6 0.0 1.6 1 0 0 1 1 1 0 Syndecan domain DUF1640 PF07798.11 AET38618.1 - 3.9e-21 75.9 1.8 6.1e-21 75.3 1.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) RF-1 PF00472.20 AET38619.1 - 1.8e-20 73.0 3.5 3.3e-20 72.2 3.5 1.4 1 0 0 1 1 1 1 RF-1 domain Fungal_trans PF04082.18 AET38620.1 - 8.9e-15 54.4 3.3 2.1e-14 53.2 3.3 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET38620.1 - 2.3e-05 24.4 10.1 6e-05 23.1 10.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TMEM107 PF14995.6 AET38620.1 - 0.11 12.9 1.2 0.24 11.9 0.6 1.8 2 0 0 2 2 2 0 Transmembrane protein CPSF73-100_C PF11718.8 AET38621.1 - 1e-55 188.7 1.6 1.6e-55 188.0 1.6 1.3 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 AET38621.1 - 8.2e-31 106.6 0.0 1.9e-30 105.4 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.27 AET38621.1 - 7.6e-22 78.3 0.6 1.3e-21 77.5 0.6 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 AET38621.1 - 7.2e-20 71.2 0.0 1.6e-19 70.1 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 AET38621.1 - 5.4e-17 61.5 0.0 1.3e-16 60.3 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 AET38621.1 - 9.6e-06 25.2 0.1 0.00038 20.0 0.2 2.6 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AET38621.1 - 3e-05 24.0 0.1 0.00014 21.8 0.1 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 AET38621.1 - 0.095 11.9 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Putative beta-lactamase-like family LSM PF01423.22 AET38622.1 - 3.1e-18 65.2 0.2 4e-18 64.9 0.2 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 AET38622.1 - 0.0086 15.7 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 Hfq protein MCM PF00493.23 AET38623.1 - 1.5e-102 341.4 0.1 3.4e-102 340.3 0.0 1.6 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 AET38623.1 - 2e-35 121.4 0.1 4e-35 120.4 0.1 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AET38623.1 - 3.7e-29 101.0 2.0 1e-28 99.6 2.0 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 AET38623.1 - 8.8e-14 52.0 0.0 2.2e-13 50.7 0.0 1.7 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 AET38623.1 - 1.4e-05 25.1 0.0 3.7e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 AET38623.1 - 2.2e-05 24.0 0.0 0.0037 16.7 0.0 2.4 1 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 AET38623.1 - 0.0012 18.7 0.0 0.0043 16.9 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 AET38623.1 - 0.055 13.2 0.0 1.7 8.3 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase_C PF13335.6 AET38623.1 - 0.21 12.2 2.6 1.8 9.3 0.2 2.7 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI C-terminal Phage_GP20 PF06810.11 AET38624.1 - 7.7e-05 22.5 15.7 0.00013 21.8 8.2 2.6 1 1 2 3 3 3 1 Phage minor structural protein GP20 Jnk-SapK_ap_N PF09744.9 AET38624.1 - 0.00014 22.1 10.7 0.00027 21.2 10.7 1.5 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 DUF724 PF05266.14 AET38624.1 - 0.00015 21.7 6.8 0.00028 20.8 6.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF724) Golgin_A5 PF09787.9 AET38624.1 - 0.009 15.5 10.5 0.012 15.1 10.5 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 5 UPF0242 PF06785.11 AET38624.1 - 0.0091 16.1 15.3 0.022 14.9 15.3 1.6 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus FAM76 PF16046.5 AET38624.1 - 0.014 14.7 7.1 0.023 14.1 7.1 1.4 1 0 0 1 1 1 0 FAM76 protein bZIP_1 PF00170.21 AET38624.1 - 0.014 15.4 10.6 0.13 12.4 1.1 3.6 2 1 1 3 3 3 0 bZIP transcription factor HALZ PF02183.18 AET38624.1 - 0.038 14.2 11.1 3.7 7.8 0.0 4.8 3 2 2 5 5 4 0 Homeobox associated leucine zipper TMF_TATA_bd PF12325.8 AET38624.1 - 0.062 13.5 10.2 0.078 13.2 3.5 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding ATG16 PF08614.11 AET38624.1 - 0.067 13.4 16.5 0.043 14.0 5.9 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 AET38624.1 - 0.077 13.0 14.9 0.4 10.7 2.9 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HAUS-augmin3 PF14932.6 AET38624.1 - 0.082 12.5 10.8 0.02 14.5 6.2 1.9 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Cep57_CLD_2 PF14197.6 AET38624.1 - 0.1 12.7 10.1 1.3 9.2 0.7 2.5 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 KASH_CCD PF14662.6 AET38624.1 - 0.23 11.2 15.5 7.2 6.4 15.6 2.4 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DUF272 PF03312.15 AET38624.1 - 0.25 11.6 2.2 0.51 10.6 2.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF272) Spc7 PF08317.11 AET38624.1 - 0.3 9.9 15.6 1.4 7.8 15.0 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein BST2 PF16716.5 AET38624.1 - 0.31 11.6 13.4 0.62 10.7 3.3 2.4 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF5082 PF16888.5 AET38624.1 - 0.33 11.3 11.9 2.1 8.6 6.2 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) Rootletin PF15035.6 AET38624.1 - 0.35 10.9 12.6 2.2 8.3 0.7 2.5 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion YabA PF06156.13 AET38624.1 - 0.35 11.5 14.0 0.76 10.4 3.1 2.9 1 1 2 3 3 3 0 Initiation control protein YabA SlyX PF04102.12 AET38624.1 - 0.38 11.4 8.0 0.19 12.4 1.9 2.6 1 1 1 2 2 2 0 SlyX DivIC PF04977.15 AET38624.1 - 0.44 10.4 15.3 1.5 8.7 1.7 3.4 2 1 1 3 3 3 0 Septum formation initiator Cnn_1N PF07989.11 AET38624.1 - 0.51 10.5 17.4 6.8 6.9 12.6 3.1 1 1 2 3 3 3 0 Centrosomin N-terminal motif 1 DUF641 PF04859.12 AET38624.1 - 0.61 10.4 8.8 1.8 8.9 1.7 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) CENP-H PF05837.12 AET38624.1 - 0.67 10.4 14.2 0.34 11.3 2.2 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF3450 PF11932.8 AET38624.1 - 0.78 9.0 13.0 0.71 9.1 5.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Tup_N PF08581.10 AET38624.1 - 0.79 10.1 10.7 0.17 12.2 2.5 2.6 1 1 1 2 2 2 0 Tup N-terminal ZapB PF06005.12 AET38624.1 - 0.95 10.0 20.9 13 6.3 9.5 2.9 1 1 1 2 2 2 0 Cell division protein ZapB Mod_r PF07200.13 AET38624.1 - 1.3 9.2 14.5 1.3 9.2 10.7 2.2 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein XRCC4 PF06632.12 AET38624.1 - 1.3 7.8 13.9 2.2 7.0 13.5 1.4 1 1 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 TPR_MLP1_2 PF07926.12 AET38624.1 - 1.4 8.9 14.5 0.53 10.3 4.2 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 AET38624.1 - 1.6 9.3 12.2 4.6 7.8 3.3 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF4407 PF14362.6 AET38624.1 - 1.7 7.9 6.3 2.5 7.4 6.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CREPT PF16566.5 AET38624.1 - 2.9 8.0 11.6 3.1 8.0 2.6 2.6 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour KELK PF15796.5 AET38624.1 - 8.2 7.0 12.9 3.6 8.1 6.2 2.4 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase BRE1 PF08647.11 AET38624.1 - 9.7 6.3 17.4 51 4.0 12.0 2.6 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Cnd1 PF12717.7 AET38625.1 - 1.3e-51 174.9 9.3 4e-44 150.5 0.6 4.4 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.7 AET38625.1 - 4e-44 150.4 1.1 4e-44 150.4 1.1 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT PF02985.22 AET38625.1 - 3.2e-10 39.4 3.0 0.75 10.2 0.0 6.7 6 0 0 6 6 6 4 HEAT repeat HEAT_2 PF13646.6 AET38625.1 - 1.5e-09 38.1 0.0 0.0082 16.5 0.0 4.5 3 2 1 4 4 4 3 HEAT repeats Cnd3 PF12719.7 AET38625.1 - 3.5e-08 33.0 8.4 1.9e-06 27.3 0.8 3.4 3 1 0 3 3 3 2 Nuclear condensing complex subunits, C-term domain HEAT_EZ PF13513.6 AET38625.1 - 4.2e-05 23.9 2.5 0.91 10.1 0.0 5.2 5 0 0 5 5 5 1 HEAT-like repeat RTP1_C1 PF10363.9 AET38625.1 - 0.046 13.9 4.6 3.8 7.7 0.1 4.6 4 1 1 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 F-protein PF00469.20 AET38625.1 - 0.56 9.8 2.3 0.67 9.5 0.1 2.0 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef Ferrochelatase PF00762.19 AET38626.1 - 1.2e-92 310.4 0.0 1.4e-92 310.2 0.0 1.1 1 0 0 1 1 1 1 Ferrochelatase MBOAT PF03062.19 AET38627.1 - 7.1e-69 232.8 15.0 1.2e-68 232.0 15.0 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Med4 PF10018.9 AET38628.1 - 3.3e-32 111.7 4.5 3.3e-32 111.7 4.5 1.6 2 0 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 DUF4187 PF13821.6 AET38629.1 - 2e-18 65.9 3.1 5.8e-18 64.4 3.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 AET38629.1 - 5.5e-06 26.2 1.2 9.9e-06 25.4 1.2 1.5 1 0 0 1 1 1 1 G-patch domain DcpS PF05652.12 AET38630.1 - 5.2e-37 126.9 0.3 8.2e-37 126.2 0.3 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.8 AET38630.1 - 2.9e-33 114.7 0.6 9.1e-33 113.1 0.1 1.9 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding Longin PF13774.6 AET38631.1 - 5.5e-19 68.0 0.3 9.5e-19 67.2 0.3 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 AET38631.1 - 1.1e-14 53.9 0.0 2e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 Synaptobrevin DUF1664 PF07889.12 AET38631.1 - 0.0057 16.7 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) NUDIX PF00293.28 AET38632.1 - 3.5e-20 72.4 0.1 4.2e-20 72.1 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain Gon7 PF08738.10 AET38632.1 - 0.099 12.7 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Gon7 family DUF410 PF04190.13 AET38633.1 - 2e-70 237.5 0.5 2.4e-70 237.3 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) SNAP PF14938.6 AET38633.1 - 0.0061 16.0 0.5 1.1 8.6 0.4 2.2 2 0 0 2 2 2 2 Soluble NSF attachment protein, SNAP RHD3 PF05879.12 AET38634.1 - 4.8e-227 755.7 15.1 5.8e-227 755.4 15.1 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.23 AET38634.1 - 2.4e-05 24.5 0.5 7.7e-05 22.8 0.0 2.1 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 AET38634.1 - 2.7e-05 24.2 0.0 8.1e-05 22.7 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase GBP PF02263.19 AET38634.1 - 4.3e-05 22.9 0.4 4.3e-05 22.9 0.4 1.9 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain Septin PF00735.18 AET38634.1 - 0.0042 16.4 0.0 0.014 14.7 0.0 1.8 1 0 0 1 1 1 1 Septin SecA_SW PF07516.13 AET38634.1 - 0.024 14.7 2.0 0.053 13.6 1.4 1.9 1 1 0 1 1 1 0 SecA Wing and Scaffold domain Roc PF08477.13 AET38634.1 - 0.047 13.9 0.7 0.17 12.1 0.1 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 AET38634.1 - 0.073 13.3 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 AET38634.1 - 0.12 12.8 0.2 1.2 9.5 0.0 2.7 3 1 0 3 3 3 0 AAA ATPase domain AAA_23 PF13476.6 AET38634.1 - 1.2 9.6 0.0 1.2 9.6 0.0 3.2 3 1 0 3 3 3 0 AAA domain PdaC PF13739.6 AET38634.1 - 7.1 7.7 5.9 21 6.2 0.2 3.4 2 1 0 2 2 2 0 Deacetylase PdaC DinB PF05163.12 AET38635.1 - 0.016 15.1 0.1 0.027 14.4 0.1 1.3 1 0 0 1 1 1 0 DinB family PIN_4 PF13638.6 AET38636.1 - 5.7e-30 104.3 1.7 6e-30 104.2 0.1 1.9 2 0 0 2 2 2 1 PIN domain PIN_9 PF18477.1 AET38636.1 - 0.02 15.2 0.2 0.51 10.7 0.0 2.4 1 1 1 2 2 2 0 PIN like domain DUF4116 PF13475.6 AET38636.1 - 0.14 11.9 1.0 0.73 9.6 1.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4116) Ribosomal_S28e PF01200.18 AET38637.1 - 1.6e-32 111.2 2.0 1.8e-32 111.1 2.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e S_layer_C PF05124.12 AET38637.1 - 0.11 12.5 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 S-layer like family, C-terminal region Red1 PF07964.11 AET38638.1 - 1e-260 867.2 34.7 1.2e-260 867.0 34.7 1.0 1 0 0 1 1 1 1 Rec10 / Red1 tRNA-synt_1c PF00749.21 AET38639.1 - 1.6e-113 378.7 0.0 3e-113 377.9 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.15 AET38639.1 - 2.4e-49 167.5 0.9 3.6e-49 166.9 0.9 1.3 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.18 AET38639.1 - 1.2e-31 109.9 0.0 1.2e-30 106.7 0.0 2.3 1 1 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.15 AET38639.1 - 2.9e-14 53.7 0.7 8.7e-14 52.2 0.7 1.8 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 TMA7 PF09072.10 AET38640.1 - 4.4e-22 78.7 20.0 4.8e-22 78.5 20.0 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 DUF3987 PF13148.6 AET38640.1 - 0.31 10.0 1.9 0.32 10.0 1.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Ras PF00071.22 AET38641.1 - 2.8e-55 186.3 0.3 3.3e-55 186.1 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET38641.1 - 4e-37 127.1 0.1 6.1e-37 126.5 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET38641.1 - 3e-16 59.3 0.2 4.1e-16 58.9 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AET38641.1 - 1.2e-05 24.8 0.3 1.5e-05 24.5 0.3 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AET38641.1 - 1.6e-05 24.9 0.0 2.7e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AET38641.1 - 2.4e-05 24.0 0.1 0.00026 20.6 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 AET38641.1 - 2.8e-05 23.6 0.0 4.1e-05 23.1 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 AET38641.1 - 7.2e-05 22.8 0.1 0.072 13.0 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_7 PF12775.7 AET38641.1 - 0.0058 16.2 0.0 0.0094 15.5 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region ATPase_2 PF01637.18 AET38641.1 - 0.007 16.3 0.2 0.016 15.2 0.2 1.5 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 AET38641.1 - 0.016 14.9 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 AET38641.1 - 0.016 14.9 0.3 0.045 13.5 0.3 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 AET38641.1 - 0.032 14.6 0.0 0.053 13.9 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 AET38641.1 - 0.039 14.2 0.0 0.098 12.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain DLIC PF05783.11 AET38641.1 - 0.048 12.5 0.0 0.073 11.9 0.0 1.4 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) NACHT PF05729.12 AET38641.1 - 0.082 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain DAGK_cat PF00781.24 AET38642.1 - 7.1e-26 90.3 0.0 1.2e-25 89.6 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain ATG22 PF11700.8 AET38643.1 - 1.4e-120 403.1 19.8 1.7e-120 402.9 19.8 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like Caroten_synth PF04240.12 AET38643.1 - 0.0041 17.0 0.9 0.0041 17.0 0.9 2.9 4 0 0 4 4 4 1 Carotenoid biosynthesis protein Cpn60_TCP1 PF00118.24 AET38644.1 - 7.4e-85 285.4 11.7 6.4e-84 282.3 11.7 1.9 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Mito_fiss_Elm1 PF06258.11 AET38644.1 - 0.077 12.1 0.1 0.5 9.4 0.1 2.0 1 1 1 2 2 2 0 Mitochondrial fission ELM1 DUF1542 PF07564.11 AET38644.1 - 5.8 7.1 11.6 1.4 9.0 1.7 3.1 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1542) Glyco_hydro_125 PF06824.11 AET38645.1 - 4.5e-165 549.6 0.0 5.4e-165 549.3 0.0 1.1 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) EMC3_TMCO1 PF01956.16 AET38646.1 - 7.3e-52 175.5 1.6 8.7e-52 175.3 1.6 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like ATP_bind_1 PF03029.17 AET38647.1 - 1.7e-80 270.3 0.1 2.4e-80 269.8 0.1 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 AET38647.1 - 1.8e-07 30.9 0.2 3.8e-06 26.6 0.2 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 AET38647.1 - 6.8e-05 22.0 0.0 0.062 12.3 0.0 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 AET38647.1 - 0.00011 22.1 0.0 0.00023 20.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 AET38647.1 - 0.0002 21.4 0.0 0.007 16.4 0.0 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 AET38647.1 - 0.00029 20.6 0.1 0.011 15.5 0.0 2.5 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 AET38647.1 - 0.00055 20.1 0.0 0.0022 18.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AET38647.1 - 0.00056 20.2 0.1 0.0036 17.6 0.0 2.4 3 0 0 3 3 2 1 AAA domain RsgA_GTPase PF03193.16 AET38647.1 - 0.0012 18.8 0.5 3.4 7.6 0.2 3.3 2 1 0 2 2 2 2 RsgA GTPase NACHT PF05729.12 AET38647.1 - 0.0013 18.7 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 NACHT domain CLP1_P PF16575.5 AET38647.1 - 0.0013 18.5 0.0 0.61 9.8 0.0 2.4 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop FeoB_N PF02421.18 AET38647.1 - 0.0014 18.2 0.1 0.032 13.8 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B cobW PF02492.19 AET38647.1 - 0.0024 17.5 0.1 0.022 14.4 0.1 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 AET38647.1 - 0.0025 17.3 0.0 0.0049 16.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_18 PF13238.6 AET38647.1 - 0.0031 18.0 0.3 0.016 15.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain SRP54 PF00448.22 AET38647.1 - 0.0037 16.9 0.2 0.038 13.6 0.0 2.5 3 0 0 3 3 2 1 SRP54-type protein, GTPase domain SRPRB PF09439.10 AET38647.1 - 0.0085 15.5 0.2 0.63 9.4 0.0 2.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 AET38647.1 - 0.01 16.0 0.1 1 9.6 0.0 2.8 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_30 PF13604.6 AET38647.1 - 0.013 15.2 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 AET38647.1 - 0.014 15.8 0.0 0.03 14.7 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 AET38647.1 - 0.02 14.1 0.0 0.044 13.0 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain CbiA PF01656.23 AET38647.1 - 0.03 14.4 0.0 0.063 13.3 0.0 1.6 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain KTI12 PF08433.10 AET38647.1 - 0.035 13.5 0.0 0.075 12.5 0.0 1.6 1 0 0 1 1 1 0 Chromatin associated protein KTI12 PRK PF00485.18 AET38647.1 - 0.054 13.2 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Arf PF00025.21 AET38647.1 - 0.064 12.7 0.0 4.9 6.6 0.0 2.5 2 1 0 2 2 2 0 ADP-ribosylation factor family MobB PF03205.14 AET38647.1 - 0.083 12.8 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Pox_D5 PF03288.16 AET38647.1 - 0.09 13.3 0.2 7.5 7.1 0.0 3.0 3 0 0 3 3 2 0 Poxvirus D5 protein-like AAA_31 PF13614.6 AET38647.1 - 0.11 12.5 0.0 4.6 7.1 0.0 2.3 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 AET38647.1 - 0.12 12.1 0.0 0.33 10.7 0.0 1.7 2 0 0 2 2 1 0 Viral (Superfamily 1) RNA helicase DUF87 PF01935.17 AET38647.1 - 0.13 12.3 1.5 1.6 8.8 0.0 2.5 2 1 0 2 2 2 0 Helicase HerA, central domain AAA_5 PF07728.14 AET38647.1 - 0.13 12.2 0.0 1.1 9.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PAC2 PF09754.9 AET38648.1 - 2.2e-24 86.6 0.0 2.9e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 PAC2 family HEAT_2 PF13646.6 AET38649.1 - 6.2e-33 113.1 0.6 7.5e-16 58.3 0.0 3.1 2 1 1 3 3 3 2 HEAT repeats HEAT_PBS PF03130.16 AET38649.1 - 1e-16 59.9 0.3 0.00049 20.5 0.0 6.3 6 0 0 6 6 6 4 PBS lyase HEAT-like repeat HEAT PF02985.22 AET38649.1 - 3.7e-15 54.7 0.1 0.015 15.5 0.0 5.7 6 0 0 6 6 6 4 HEAT repeat HEAT_EZ PF13513.6 AET38649.1 - 6.4e-08 32.9 0.5 0.08 13.5 0.1 5.1 4 1 1 5 5 5 3 HEAT-like repeat Arm PF00514.23 AET38649.1 - 0.00066 19.6 0.5 3.1 8.0 0.0 4.2 2 2 2 4 4 4 1 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 AET38649.1 - 0.0043 17.1 1.2 0.94 9.5 0.1 3.5 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 NblA PF04485.12 AET38649.1 - 0.05 14.0 0.5 4.2 7.8 0.1 2.9 2 0 0 2 2 2 0 Phycobilisome degradation protein nblA Cohesin_HEAT PF12765.7 AET38649.1 - 0.12 12.7 2.1 5.9 7.3 0.4 3.2 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Ham1p_like PF01725.16 AET38650.1 - 6.3e-50 169.7 0.0 7.1e-50 169.5 0.0 1.0 1 0 0 1 1 1 1 Ham1 family SEF14_adhesin PF06443.11 AET38650.1 - 0.019 14.8 0.0 0.029 14.2 0.0 1.2 1 0 0 1 1 1 0 SEF14-like adhesin Xpo1 PF08389.12 AET38651.1 - 3.4e-40 137.5 2.4 1.2e-39 135.7 0.6 2.8 2 0 0 2 2 2 1 Exportin 1-like protein BEN PF10523.9 AET38651.1 - 0.09 13.0 0.1 0.5 10.6 0.0 2.2 2 0 0 2 2 2 0 BEN domain Rep_fac_C PF08542.11 AET38653.1 - 7.3e-17 61.6 0.0 1.8e-16 60.3 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 AET38653.1 - 1.1e-16 61.4 0.0 6e-16 59.1 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 AET38653.1 - 5.4e-14 52.3 0.0 5.1e-13 49.1 0.0 2.1 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 AET38653.1 - 3.9e-09 36.7 0.1 8e-09 35.7 0.1 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 AET38653.1 - 1.6e-05 24.7 0.0 4.6e-05 23.2 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 AET38653.1 - 2.6e-05 24.5 0.0 0.00023 21.4 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AET38653.1 - 9.7e-05 22.8 0.0 0.0056 17.1 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_assoc_2 PF16193.5 AET38653.1 - 0.0001 22.5 0.1 0.0003 21.1 0.1 1.9 1 0 0 1 1 1 1 AAA C-terminal domain AAA_11 PF13086.6 AET38653.1 - 0.00012 22.0 0.1 0.00026 20.8 0.0 1.4 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 AET38653.1 - 0.00024 20.5 0.0 0.0056 16.1 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 AET38653.1 - 0.0015 18.5 0.0 0.0041 17.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AET38653.1 - 0.0024 18.2 0.0 0.011 16.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 AET38653.1 - 0.0025 17.0 0.0 0.004 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 AET38653.1 - 0.0025 17.6 0.0 0.005 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 AET38653.1 - 0.0039 16.7 0.0 0.0067 16.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_30 PF13604.6 AET38653.1 - 0.0049 16.6 0.0 0.0096 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 AET38653.1 - 0.0084 15.9 0.0 0.026 14.3 0.0 1.8 1 0 0 1 1 1 1 DNA polymerase III, delta subunit ResIII PF04851.15 AET38653.1 - 0.0091 16.0 0.0 0.049 13.6 0.0 2.0 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_5 PF07728.14 AET38653.1 - 0.014 15.4 0.2 0.11 12.5 0.1 2.5 2 1 0 2 2 1 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 AET38653.1 - 0.017 15.7 0.0 0.042 14.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 AET38653.1 - 0.02 14.2 0.0 0.059 12.6 0.0 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 AET38653.1 - 0.044 13.5 0.1 0.28 10.9 0.0 2.1 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_3 PF07726.11 AET38653.1 - 0.046 13.6 0.0 0.35 10.7 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 AET38653.1 - 0.078 12.9 0.0 0.21 11.5 0.0 1.7 2 0 0 2 2 1 0 RsgA GTPase TIP49_C PF17856.1 AET38653.1 - 0.093 12.9 0.2 0.24 11.6 0.2 1.7 1 0 0 1 1 1 0 TIP49 AAA-lid domain Propeptide_C1 PF08127.13 AET38653.1 - 0.098 12.6 0.0 1.4 8.9 0.1 2.4 2 0 0 2 2 2 0 Peptidase family C1 propeptide AAA_28 PF13521.6 AET38653.1 - 0.099 12.9 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 AET38653.1 - 0.11 13.0 0.2 0.51 10.9 0.0 2.2 2 2 0 2 2 2 0 AAA domain Yae1_N PF09811.9 AET38654.1 - 4.5e-12 45.5 0.3 6.1e-12 45.0 0.3 1.2 1 0 0 1 1 1 1 Essential protein Yae1, N terminal FAT PF02259.23 AET38655.1 - 6.8e-141 469.5 1.7 6.8e-141 469.5 1.7 2.7 3 0 0 3 3 3 1 FAT domain PI3_PI4_kinase PF00454.27 AET38655.1 - 5.1e-73 245.9 0.0 1e-72 244.9 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 AET38655.1 - 3e-69 232.0 21.2 5.4e-66 221.5 0.9 5.9 6 1 1 7 7 7 2 Domain of unknown function (DUF3385) FRB_dom PF08771.11 AET38655.1 - 2.6e-43 146.5 5.0 2.8e-43 146.3 0.5 3.4 3 0 0 3 3 2 1 FKBP12-rapamycin binding domain FATC PF02260.20 AET38655.1 - 3.7e-17 61.8 0.4 9.3e-17 60.5 0.4 1.8 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.6 AET38655.1 - 1e-09 38.6 5.7 0.19 12.1 0.0 8.1 8 1 0 8 8 8 2 HEAT repeats HEAT PF02985.22 AET38655.1 - 1.2e-08 34.5 6.0 0.0089 16.2 0.0 7.5 8 0 0 8 8 7 2 HEAT repeat HEAT_EZ PF13513.6 AET38655.1 - 7.7e-08 32.7 0.7 0.0049 17.3 0.0 7.1 6 1 1 7 7 7 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 AET38655.1 - 0.0093 16.6 8.6 2.5 8.8 0.0 6.4 6 0 0 6 6 6 1 Vacuolar 14 Fab1-binding region DUF3437 PF11919.8 AET38655.1 - 0.046 13.6 0.1 1.6 8.7 0.0 3.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) MOR2-PAG1_C PF14225.6 AET38655.1 - 0.069 13.0 1.5 21 4.8 0.4 3.6 2 1 1 3 3 3 0 Cell morphogenesis C-terminal HrpB1_HrpK PF09613.10 AET38655.1 - 0.091 12.4 0.2 1 9.0 0.0 2.8 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) DUF727 PF05303.12 AET38655.1 - 0.11 12.6 0.5 0.45 10.6 0.5 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF727) Actin PF00022.19 AET38656.1 - 9.8e-89 297.8 0.0 2.6e-86 289.8 0.0 2.1 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 AET38656.1 - 0.00013 20.9 0.0 0.021 13.7 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 AET38656.1 - 0.0007 20.0 0.0 0.0022 18.4 0.0 1.9 2 1 0 2 2 2 1 Cell division protein FtsA DUF5474 PF17568.2 AET38656.1 - 0.086 12.9 0.1 2.4 8.3 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5474) Cpn60_TCP1 PF00118.24 AET38657.1 - 5.2e-151 503.6 3.8 5.9e-151 503.4 3.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cation_ATPase PF13246.6 AET38657.1 - 0.041 14.0 0.0 0.16 12.1 0.0 2.0 2 0 0 2 2 2 0 Cation transport ATPase (P-type) Resolvase PF00239.21 AET38657.1 - 0.08 13.0 0.1 2.5 8.2 0.1 2.5 2 0 0 2 2 2 0 Resolvase, N terminal domain CPT PF07931.12 AET38657.1 - 0.091 12.6 1.8 8.7 6.2 0.2 2.7 2 1 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein TFIIS_C PF01096.18 AET38658.1 - 7.1e-18 64.2 7.3 1e-17 63.7 1.9 2.9 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 AET38658.1 - 1.3e-10 40.9 10.7 2.6e-09 36.8 0.8 2.9 2 1 0 2 2 2 2 RNA polymerases M/15 Kd subunit DZR PF12773.7 AET38658.1 - 0.0013 18.7 7.8 0.1 12.6 0.2 3.0 2 1 0 2 2 2 2 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 AET38658.1 - 0.011 15.7 2.4 0.07 13.1 0.2 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain TackOD1 PF18551.1 AET38658.1 - 0.017 14.8 5.7 1.2 8.8 0.2 2.4 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 IBR PF01485.21 AET38658.1 - 0.029 14.6 6.2 1.5 9.1 2.1 2.4 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain C1_1 PF00130.22 AET38658.1 - 0.034 14.0 2.1 2.3 8.2 0.0 2.6 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-H2C2_2 PF13465.6 AET38658.1 - 0.05 14.1 3.9 0.75 10.3 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger double domain TF_Zn_Ribbon PF08271.12 AET38658.1 - 0.1 12.1 13.3 0.63 9.6 3.4 3.1 2 2 1 3 3 3 0 TFIIB zinc-binding zinc_ribbon_4 PF13717.6 AET38658.1 - 0.1 12.5 8.8 4.4 7.3 0.2 3.6 4 0 0 4 4 4 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 AET38658.1 - 0.12 12.5 10.1 11 6.3 1.1 3.3 3 0 0 3 3 3 0 Zinc ribbon domain GATA PF00320.27 AET38658.1 - 0.15 11.7 0.2 0.15 11.7 0.2 2.9 3 1 0 3 3 3 0 GATA zinc finger DUF3716 PF12511.8 AET38658.1 - 0.19 11.8 3.7 0.53 10.4 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3716) zf-C4_Topoisom PF01396.19 AET38658.1 - 0.23 11.3 7.4 0.14 11.9 1.2 3.0 2 1 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Baculo_LEF5_C PF11792.8 AET38658.1 - 0.31 10.8 4.8 0.1 12.3 0.9 2.4 2 1 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain zf-TFIIB PF13453.6 AET38658.1 - 0.32 10.4 4.9 0.14 11.6 0.9 2.2 2 0 0 2 2 2 0 Transcription factor zinc-finger Stc1 PF12898.7 AET38658.1 - 0.32 11.6 7.3 2.7 8.6 0.5 2.3 1 1 1 2 2 2 0 Stc1 domain zinc_ribbon_2 PF13240.6 AET38658.1 - 0.39 10.5 12.5 17 5.3 1.6 4.1 3 1 0 3 3 3 0 zinc-ribbon domain Zn_Tnp_IS1 PF03811.13 AET38658.1 - 0.56 10.0 4.0 2.5 7.9 0.0 3.0 3 0 0 3 3 3 0 InsA N-terminal domain CpXC PF14353.6 AET38658.1 - 0.77 9.8 7.4 1.9 8.5 0.2 3.1 1 1 1 3 3 3 0 CpXC protein zf-RRN7 PF11781.8 AET38658.1 - 2 8.2 9.7 5.2 6.8 0.0 3.7 4 0 0 4 4 4 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-ribbon_3 PF13248.6 AET38658.1 - 3.5 7.2 14.1 13 5.4 0.3 4.2 4 0 0 4 4 4 0 zinc-ribbon domain Nudix_N_2 PF14803.6 AET38658.1 - 7.5 6.6 9.6 26 4.8 1.8 3.7 3 1 0 3 3 3 0 Nudix N-terminal PRCC PF10253.9 AET38659.1 - 0.0002 22.3 4.9 0.0002 22.3 4.9 1.7 2 0 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting SSP160 PF06933.11 AET38659.1 - 0.41 8.8 4.5 0.51 8.5 4.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3439 PF11921.8 AET38659.1 - 3.2 7.7 8.1 5.4 7.0 8.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) LicD PF04991.13 AET38660.1 - 4.9e-45 154.4 0.5 4.9e-45 154.4 0.5 3.3 3 1 0 3 3 3 1 LicD family CAF-1_p150 PF11600.8 AET38660.1 - 1.1 9.0 56.0 0.015 15.0 47.1 2.0 1 1 1 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal HSP70 PF00012.20 AET38660.1 - 8.5 4.4 23.0 12 3.9 23.0 1.2 1 0 0 1 1 1 0 Hsp70 protein K_trans PF02705.16 AET38661.1 - 2.1e-172 574.4 23.7 2.5e-172 574.1 23.7 1.0 1 0 0 1 1 1 1 K+ potassium transporter HLH PF00010.26 AET38662.1 - 4.6e-12 45.7 3.5 8.8e-12 44.8 3.5 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Ribosomal_60s PF00428.19 AET38662.1 - 0.00075 20.0 6.6 0.00075 20.0 6.6 4.4 3 2 2 5 5 5 1 60s Acidic ribosomal protein DUF2465 PF10239.9 AET38662.1 - 0.017 14.4 6.0 0.024 13.9 6.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2465) UPF0175 PF03683.13 AET38662.1 - 0.023 14.4 0.1 0.089 12.5 0.1 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0175) Sec66 PF09802.9 AET38662.1 - 0.023 14.3 3.3 0.042 13.4 3.3 1.4 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 RasGEF PF00617.19 AET38662.1 - 0.06 13.5 0.4 0.55 10.4 1.3 1.8 2 0 0 2 2 2 0 RasGEF domain L27 PF02828.16 AET38662.1 - 0.096 12.5 0.5 0.26 11.1 0.5 1.8 1 0 0 1 1 1 0 L27 domain CDC45 PF02724.14 AET38662.1 - 0.15 10.3 12.7 0.19 10.0 12.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.25 AET38663.1 - 1.3e-36 126.4 0.0 1.9e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38663.1 - 5.2e-11 42.3 0.0 1.1e-10 41.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 AET38663.1 - 0.00071 19.3 0.0 0.29 10.7 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 AET38663.1 - 0.00084 18.8 0.0 0.002 17.5 0.0 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 AET38663.1 - 0.0015 17.9 0.0 0.0031 16.9 0.0 1.6 1 1 0 1 1 1 1 Kinase-like AAA PF00004.29 AET38664.1 - 5.8e-57 191.8 0.0 6.9e-43 146.2 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 AET38664.1 - 4.7e-25 87.8 0.1 1.2e-24 86.6 0.1 1.7 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 AET38664.1 - 4.1e-17 61.7 0.1 4.1e-11 42.5 0.0 2.5 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 AET38664.1 - 1.8e-09 38.2 0.2 0.05 14.0 0.0 3.9 2 2 2 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 AET38664.1 - 8e-09 35.9 0.2 0.068 13.5 0.0 3.9 2 2 1 3 3 3 2 AAA domain IstB_IS21 PF01695.17 AET38664.1 - 3.1e-07 30.3 0.0 0.0022 17.8 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein NACHT PF05729.12 AET38664.1 - 7.3e-06 26.0 0.1 0.11 12.4 0.0 3.4 3 0 0 3 3 3 2 NACHT domain AAA_25 PF13481.6 AET38664.1 - 3e-05 23.7 0.6 1.3 8.6 0.0 4.2 3 1 1 4 4 4 1 AAA domain AAA_24 PF13479.6 AET38664.1 - 9e-05 22.3 0.0 0.038 13.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 AET38664.1 - 9.4e-05 22.6 0.0 0.0052 16.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 AET38664.1 - 9.5e-05 22.6 0.0 0.0015 18.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 AET38664.1 - 0.00011 22.3 0.0 0.12 12.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 AET38664.1 - 0.00014 21.9 0.0 0.084 12.9 0.0 3.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 AET38664.1 - 0.00015 22.1 0.0 1 9.8 0.0 2.8 2 0 0 2 2 2 2 RNA helicase ABC_tran PF00005.27 AET38664.1 - 0.00026 21.5 0.3 0.26 11.8 0.1 3.4 3 1 0 3 3 2 1 ABC transporter RuvB_N PF05496.12 AET38664.1 - 0.00026 20.7 0.0 0.0025 17.6 0.0 2.6 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain ATPase_2 PF01637.18 AET38664.1 - 0.0023 17.9 0.3 0.94 9.3 0.0 3.4 3 1 1 4 4 4 1 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 AET38664.1 - 0.0024 17.3 0.7 0.19 11.1 0.1 3.7 4 0 0 4 4 4 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 AET38664.1 - 0.0026 17.7 0.0 0.2 11.6 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 AET38664.1 - 0.0066 16.0 0.0 2.1 7.8 0.0 2.9 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_28 PF13521.6 AET38664.1 - 0.014 15.6 0.0 0.4 10.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 AET38664.1 - 0.02 14.6 0.0 0.074 12.8 0.0 1.9 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 AET38664.1 - 0.021 14.0 0.0 3.6 6.7 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain DUF2075 PF09848.9 AET38664.1 - 0.037 13.3 0.0 3.7 6.7 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.6 AET38664.1 - 0.044 14.3 0.0 0.25 11.9 0.0 2.3 2 0 0 2 2 1 0 AAA domain Bac_DnaA PF00308.18 AET38664.1 - 0.052 13.4 0.0 3.2 7.5 0.0 2.6 2 0 0 2 2 2 0 Bacterial dnaA protein AAA_17 PF13207.6 AET38664.1 - 0.084 13.3 3.3 0.85 10.0 0.0 3.4 4 0 0 4 4 3 0 AAA domain Fer4_NifH PF00142.18 AET38664.1 - 0.088 12.2 0.0 0.24 10.8 0.0 1.7 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family DNA_pol3_delta2 PF13177.6 AET38664.1 - 0.11 12.2 0.2 7.5 6.3 0.0 3.3 3 0 0 3 3 3 0 DNA polymerase III, delta subunit AAA_3 PF07726.11 AET38664.1 - 0.13 12.1 0.0 0.41 10.5 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rrp44_CSD1 PF17216.3 AET38664.1 - 0.14 11.9 0.0 0.38 10.5 0.0 1.7 1 0 0 1 1 1 0 Rrp44-like cold shock domain Zeta_toxin PF06414.12 AET38664.1 - 0.17 11.2 0.0 1.7 7.8 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin Cytidylate_kin2 PF13189.6 AET38664.1 - 0.18 11.9 0.0 0.9 9.6 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase-like family Clat_adaptor_s PF01217.20 AET38665.1 - 6.3e-47 159.1 0.3 7e-47 158.9 0.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Str_synth PF03088.16 AET38665.1 - 0.11 12.6 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Strictosidine synthase Thymidylate_kin PF02223.17 AET38666.1 - 1.5e-38 132.3 0.0 1.7e-38 132.2 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase AAA_33 PF13671.6 AET38666.1 - 0.017 15.3 0.0 0.061 13.5 0.0 1.9 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.10 AET38666.1 - 0.02 14.4 0.0 0.24 10.8 0.0 2.1 1 1 0 1 1 1 0 Chromatin associated protein KTI12 AAA_22 PF13401.6 AET38666.1 - 0.12 12.7 0.0 0.61 10.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 AET38666.1 - 0.12 12.7 0.0 0.16 12.3 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain SUR7 PF06687.12 AET38667.1 - 3.7e-39 134.5 13.2 4.8e-39 134.2 13.2 1.1 1 0 0 1 1 1 1 SUR7/PalI family SLATT_5 PF18160.1 AET38667.1 - 0.18 11.1 1.0 0.62 9.4 0.0 2.0 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Fig1 PF12351.8 AET38667.1 - 1 9.3 14.5 4.8 7.0 14.5 2.2 1 1 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 Hit1_C PF18268.1 AET38668.1 - 1.6e-35 121.1 1.0 1.6e-35 121.1 1.0 1.6 2 0 0 2 2 2 1 Hit1 C-terminal zf-HIT PF04438.16 AET38668.1 - 3.2e-11 42.9 12.1 3.2e-11 42.9 12.1 2.0 2 0 0 2 2 2 1 HIT zinc finger YL1_C PF08265.11 AET38668.1 - 0.0042 16.8 0.0 0.0089 15.8 0.0 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Cyc-maltodext_C PF10438.9 AET38668.1 - 0.0082 16.2 0.1 0.013 15.5 0.1 1.3 1 0 0 1 1 1 1 Cyclo-malto-dextrinase C-terminal domain zf-B_box PF00643.24 AET38668.1 - 0.1 12.7 14.0 0.6 10.3 9.4 2.3 2 0 0 2 2 2 0 B-box zinc finger zf-MYND PF01753.18 AET38668.1 - 0.43 10.7 14.7 0.15 12.2 11.7 1.7 2 0 0 2 2 2 0 MYND finger Suc_Fer-like PF06999.12 AET38669.1 - 1.2e-36 126.4 0.0 1.5e-36 126.1 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like MMS1_N PF10433.9 AET38670.1 - 6.1e-85 285.7 1.7 5.7e-84 282.5 0.3 2.9 3 0 0 3 3 3 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 AET38670.1 - 2.2e-52 178.4 0.7 2.8e-51 174.7 0.3 2.7 2 1 0 2 2 2 1 CPSF A subunit region Gsf2 PF11055.8 AET38671.1 - 1.5e-175 583.4 0.3 1.7e-175 583.2 0.3 1.0 1 0 0 1 1 1 1 Glucose signalling factor 2 DUF2087 PF09860.9 AET38672.1 - 0.0069 16.5 0.1 0.49 10.6 0.0 2.5 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2087) TetR_C_3 PF08362.11 AET38672.1 - 0.13 12.1 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 YcdC-like protein, C-terminal region DUF836 PF05768.14 AET38673.1 - 2.7e-16 59.7 0.5 3.4e-16 59.4 0.5 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 AET38673.1 - 0.04 14.4 0.3 0.052 14.0 0.3 1.3 1 1 0 1 1 1 0 Thioredoxin-like domain Glutaredoxin PF00462.24 AET38673.1 - 0.073 13.3 0.1 0.12 12.6 0.1 1.6 1 1 0 1 1 1 0 Glutaredoxin CALCOCO1 PF07888.11 AET38674.1 - 0.0004 19.4 12.0 0.0004 19.4 12.0 3.3 2 1 1 3 3 3 3 Calcium binding and coiled-coil domain (CALCOCO1) like APG6_N PF17675.1 AET38674.1 - 0.0073 16.8 7.6 0.0073 16.8 7.6 7.3 3 2 4 7 7 7 2 Apg6 coiled-coil region Rootletin PF15035.6 AET38674.1 - 0.0086 16.1 5.2 0.0086 16.1 5.2 6.1 3 2 2 5 5 5 1 Ciliary rootlet component, centrosome cohesion HrpB7 PF09486.10 AET38674.1 - 0.024 15.0 1.3 0.024 15.0 1.3 5.3 5 1 2 7 7 7 0 Bacterial type III secretion protein (HrpB7) TrbI_Ftype PF09677.10 AET38674.1 - 2.5 8.4 5.2 22 5.4 0.0 3.7 3 1 1 4 4 4 0 Type-F conjugative transfer system protein (TrbI_Ftype) PAP2 PF01569.21 AET38675.1 - 1.9e-25 89.2 0.3 3.9e-25 88.2 0.3 1.5 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 AET38675.1 - 0.0051 16.5 3.7 0.024 14.3 3.7 2.0 1 1 0 1 1 1 1 PAP2 superfamily DUF4131 PF13567.6 AET38675.1 - 0.054 13.1 2.7 2.9 7.5 0.4 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) NiFe_hyd_3_EhaA PF17367.2 AET38675.1 - 0.22 11.7 2.1 2 8.6 0.0 2.6 3 0 0 3 3 3 0 NiFe-hydrogenase-type-3 Eha complex subunit A Halogen_Hydrol PF10112.9 AET38675.1 - 0.22 11.5 0.1 17 5.4 0.0 2.1 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Med20 PF08612.11 AET38676.1 - 7.4e-49 166.1 0.7 8.2e-49 166.0 0.7 1.0 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex CTD_bind PF04818.13 AET38677.1 - 3.9e-18 66.0 1.1 1.3e-17 64.3 0.7 2.3 2 0 0 2 2 2 1 RNA polymerase II-binding domain. GCFC PF07842.12 AET38677.1 - 0.0012 18.5 0.2 0.0021 17.7 0.2 1.5 1 1 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein CTK3 PF12243.8 AET38677.1 - 0.017 15.1 0.2 0.13 12.3 0.1 2.2 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 MFMR_assoc PF16596.5 AET38677.1 - 0.11 12.9 7.2 0.26 11.8 3.7 2.2 2 0 0 2 2 2 0 Disordered region downstream of MFMR DEAD PF00270.29 AET38678.1 - 2.6e-24 85.9 0.0 7.2e-24 84.5 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF1998 PF09369.10 AET38678.1 - 1.7e-19 70.3 0.1 4.8e-19 68.9 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 AET38678.1 - 1.8e-12 47.6 0.4 1.9e-11 44.3 0.1 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET38678.1 - 2e-07 31.2 0.1 2e-07 31.2 0.1 2.5 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit CDT1 PF08839.11 AET38678.1 - 0.013 15.8 0.2 0.035 14.4 0.2 1.8 1 0 0 1 1 1 0 DNA replication factor CDT1 like SRX PF09201.10 AET38679.1 - 7e-56 188.2 4.2 1.9e-55 186.8 4.2 1.8 1 0 0 1 1 1 1 SRX, signal recognition particle receptor alpha subunit SRP54 PF00448.22 AET38679.1 - 6.9e-47 159.6 0.1 3.1e-44 151.0 0.1 2.5 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 AET38679.1 - 2.2e-08 34.4 4.2 4.7e-08 33.3 4.2 1.5 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.19 AET38679.1 - 9.5e-05 22.5 0.0 0.00033 20.8 0.0 1.9 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 AET38679.1 - 0.00013 21.0 0.1 0.00059 18.9 0.0 2.1 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ArsA_ATPase PF02374.15 AET38679.1 - 0.0014 17.8 0.2 0.056 12.6 0.2 2.4 1 1 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 AET38679.1 - 0.0028 17.6 0.0 0.016 15.1 0.0 2.3 1 1 0 1 1 1 1 AAA domain Fer4_NifH PF00142.18 AET38679.1 - 0.005 16.3 0.0 0.0082 15.6 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CbiA PF01656.23 AET38679.1 - 0.0073 16.4 0.0 0.029 14.4 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 AET38679.1 - 0.0086 15.8 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 AET38679.1 - 0.017 14.9 0.4 0.15 11.8 0.0 2.7 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 AET38679.1 - 0.044 13.9 2.4 1.2 9.3 0.2 3.4 2 2 1 3 3 3 0 50S ribosome-binding GTPase AAA_25 PF13481.6 AET38679.1 - 0.08 12.5 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 AET38679.1 - 0.082 13.3 0.2 5 7.5 0.2 2.9 1 1 0 1 1 1 0 AAA domain Cyt-b5 PF00173.28 AET38680.1 - 4.5e-13 49.1 0.0 9.7e-13 48.1 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.24 AET38680.1 - 1.1e-07 32.0 17.6 1.8e-07 31.3 17.6 1.3 1 0 0 1 1 1 1 Fatty acid desaturase V-ATPase_G PF03179.15 AET38681.1 - 8.4e-31 106.6 14.3 9.4e-31 106.5 14.3 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF3552 PF12072.8 AET38681.1 - 0.00031 20.2 8.9 0.00031 20.2 8.9 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF3552) DUF16 PF01519.16 AET38681.1 - 0.0058 17.1 5.2 0.0075 16.7 5.0 1.3 1 1 0 1 1 1 1 Protein of unknown function DUF16 V-ATPase_G_2 PF16999.5 AET38681.1 - 0.014 15.8 14.6 0.018 15.5 14.6 1.2 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit S_layer_C PF05124.12 AET38681.1 - 0.029 14.3 2.9 0.03 14.3 2.9 1.0 1 0 0 1 1 1 0 S-layer like family, C-terminal region MitMem_reg PF13012.6 AET38681.1 - 0.05 14.0 1.3 0.067 13.6 1.3 1.2 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function ASL_C2 PF14698.6 AET38681.1 - 0.057 14.2 2.4 0.18 12.6 2.4 1.9 1 1 0 1 1 1 0 Argininosuccinate lyase C-terminal ATP-synt_B PF00430.18 AET38681.1 - 0.17 11.9 17.3 0.65 10.1 17.3 1.8 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) Tho2 PF11262.8 AET38681.1 - 0.31 10.2 6.2 0.37 9.9 6.2 1.0 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Aldedh PF00171.22 AET38682.1 - 6.3e-128 427.2 0.0 7.4e-128 426.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family SPC25 PF06703.11 AET38682.1 - 0.023 14.5 0.1 0.041 13.7 0.1 1.3 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) RRF PF01765.19 AET38683.1 - 5.7e-40 136.9 4.8 8.2e-40 136.4 4.8 1.2 1 0 0 1 1 1 1 Ribosome recycling factor TPP_enzyme_N PF02776.18 AET38684.1 - 2.9e-33 114.9 0.0 4.2e-33 114.4 0.0 1.2 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 AET38684.1 - 2e-23 82.7 0.0 6.3e-23 81.0 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 AET38684.1 - 2.3e-14 53.4 0.0 8e-14 51.7 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain RNB PF00773.19 AET38685.1 - 1.2e-52 179.2 0.0 1.2e-52 179.2 0.0 1.7 2 0 0 2 2 2 1 RNB domain OB_Dis3 PF17849.1 AET38685.1 - 1.8e-24 85.5 0.1 5.9e-24 83.9 0.1 2.0 2 0 0 2 2 2 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 AET38685.1 - 2.8e-21 75.6 0.0 8.2e-21 74.1 0.0 1.9 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal CSD2 PF17876.1 AET38685.1 - 7.1e-07 29.3 0.0 0.00033 20.8 0.0 3.1 3 0 0 3 3 3 2 Cold shock domain Rrp44_CSD1 PF17216.3 AET38685.1 - 0.0024 17.6 0.1 0.0059 16.3 0.1 1.6 1 0 0 1 1 1 1 Rrp44-like cold shock domain OB_RNB PF08206.11 AET38685.1 - 0.0045 16.6 0.1 0.64 9.7 0.1 2.7 2 0 0 2 2 2 1 Ribonuclease B OB domain Aldedh PF00171.22 AET38686.1 - 6.5e-99 331.5 0.0 7.9e-99 331.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Brr6_like_C_C PF10104.9 AET38687.1 - 5.8e-42 142.6 0.1 7.9e-42 142.2 0.1 1.2 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain HDA2-3 PF11496.8 AET38688.1 - 5.9e-70 235.7 0.4 5.9e-70 235.7 0.4 1.9 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ABC_tran_CTD PF16326.5 AET38688.1 - 0.013 15.7 6.9 0.013 15.7 6.9 3.5 2 2 1 3 3 3 0 ABC transporter C-terminal domain GAS PF13851.6 AET38688.1 - 4.5 6.6 33.4 7.8 5.8 14.4 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Mhr1 PF12829.7 AET38689.1 - 8.1e-25 86.7 0.3 1.5e-24 85.9 0.3 1.5 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination FA_hydroxylase PF04116.13 AET38690.1 - 8.9e-20 71.4 13.2 8.9e-20 71.4 13.2 2.0 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily OSCP PF00213.18 AET38691.1 - 3.1e-41 141.3 3.3 3.6e-41 141.1 3.3 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit TRAUB PF08164.12 AET38692.1 - 1.5e-23 83.1 4.2 3.2e-23 82.1 0.1 3.2 3 0 0 3 3 3 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 AET38692.1 - 3.4e-22 79.6 3.3 3.4e-22 79.6 3.3 2.5 3 0 0 3 3 3 1 Apoptosis antagonizing transcription factor MatE PF01554.18 AET38693.1 - 5.4e-52 175.7 27.4 8.1e-30 103.6 11.1 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 AET38693.1 - 1.5e-07 31.6 8.5 1.5e-07 31.6 8.5 4.8 3 2 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain Pih1_fungal_CS PF18482.1 AET38694.1 - 9.8e-28 96.5 2.1 1.6e-27 95.9 0.7 2.1 2 0 0 2 2 2 1 Fungal Pih1 CS domain PIH1 PF08190.12 AET38694.1 - 8e-23 80.7 0.9 1.3e-22 80.0 0.9 1.3 1 0 0 1 1 1 1 PIH1 N-terminal domain AA_kinase PF00696.28 AET38695.1 - 1e-31 110.4 0.1 1.9e-31 109.5 0.1 1.4 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 AET38695.1 - 3.6e-18 65.3 0.0 8.5e-18 64.1 0.0 1.7 1 0 0 1 1 1 1 PUA domain CPSF_A PF03178.15 AET38696.1 - 1.2e-92 310.7 0.5 6e-92 308.4 0.1 2.2 2 0 0 2 2 2 1 CPSF A subunit region HPS3_N PF14761.6 AET38696.1 - 0.026 14.1 3.0 5.3 6.5 0.1 3.2 4 0 0 4 4 4 0 Hermansky-Pudlak syndrome 3 Coilin_N PF15862.5 AET38696.1 - 0.067 13.0 0.1 0.19 11.5 0.1 1.7 1 0 0 1 1 1 0 Coilin N-terminus PIG-F PF06699.11 AET38697.1 - 3.5e-25 89.2 18.3 4e-24 85.8 18.3 2.0 1 1 0 1 1 1 1 GPI biosynthesis protein family Pig-F TauE PF01925.19 AET38697.1 - 0.0026 17.4 2.1 0.0033 17.1 2.1 1.2 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE AIM24 PF01987.17 AET38698.1 - 6.1e-09 36.0 0.0 8.3e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 Zn_clus PF00172.18 AET38699.1 - 7.2e-08 32.4 7.1 1.7e-07 31.3 7.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3770 PF12603.8 AET38699.1 - 0.0011 18.6 0.0 0.002 17.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3770) Pro_isomerase PF00160.21 AET38700.1 - 2.7e-45 154.5 0.0 3.2e-45 154.2 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Med6 PF04934.14 AET38701.1 - 5e-54 181.7 2.7 6.3e-54 181.4 2.7 1.1 1 0 0 1 1 1 1 MED6 mediator sub complex component IGR PF09597.10 AET38702.1 - 5.2e-24 84.1 0.4 9.6e-24 83.2 0.4 1.5 1 0 0 1 1 1 1 IGR protein motif HIT PF01230.23 AET38703.1 - 1.1e-26 93.4 0.2 2e-26 92.6 0.2 1.4 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 AET38703.1 - 3.3e-07 30.8 0.4 5.2e-07 30.1 0.4 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding NAT PF04768.13 AET38703.1 - 0.0017 18.1 0.0 0.0024 17.6 0.0 1.2 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase CwfJ_C_1 PF04677.15 AET38703.1 - 0.0066 16.3 0.1 0.011 15.6 0.1 1.4 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Mob_Pre PF01076.19 AET38703.1 - 0.02 14.7 0.1 0.029 14.2 0.1 1.2 1 0 0 1 1 1 0 Plasmid recombination enzyme DUF4834 PF16118.5 AET38705.1 - 0.0011 19.9 0.4 0.0043 18.0 0.4 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) TFIIA PF03153.13 AET38705.1 - 0.0036 17.4 15.4 0.0063 16.6 15.4 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 AET38705.1 - 0.0038 16.3 13.2 0.006 15.6 13.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF2203 PF09969.9 AET38705.1 - 0.0062 17.3 2.5 0.019 15.7 2.1 2.0 2 0 0 2 2 1 1 Uncharacterized conserved protein (DUF2203) MPM1 PF17234.2 AET38705.1 - 0.02 15.1 8.8 0.058 13.7 8.8 1.7 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Neur_chan_memb PF02932.16 AET38705.1 - 0.046 13.8 0.2 0.12 12.5 0.2 1.7 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_C58 PF03543.14 AET38705.1 - 0.054 13.2 9.4 0.095 12.4 9.4 1.4 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen O-antigen_lig PF13425.6 AET38705.1 - 0.076 11.8 0.5 0.12 11.2 0.5 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Spt20 PF12090.8 AET38705.1 - 0.09 12.4 25.9 0.2 11.3 25.9 1.5 1 0 0 1 1 1 0 Spt20 family Exonuc_VII_L PF02601.15 AET38705.1 - 0.095 12.3 6.0 0.17 11.4 3.5 2.0 2 0 0 2 2 2 0 Exonuclease VII, large subunit RED_N PF07808.13 AET38705.1 - 0.19 11.3 11.1 1.9 8.0 9.4 2.4 2 0 0 2 2 2 0 RED-like protein N-terminal region EPL1 PF10513.9 AET38705.1 - 0.45 10.9 10.1 1 9.7 7.6 2.4 2 0 0 2 2 2 0 Enhancer of polycomb-like TERB2 PF15101.6 AET38705.1 - 0.46 10.5 9.8 0.89 9.6 9.8 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Presenilin PF01080.17 AET38705.1 - 0.74 8.5 6.4 1.2 7.8 6.4 1.3 1 0 0 1 1 1 0 Presenilin UPF0560 PF10577.9 AET38705.1 - 1.8 6.9 14.6 0.24 9.8 9.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 RBM39linker PF15519.6 AET38705.1 - 2.7 9.1 9.8 6.5 7.9 9.8 1.6 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein TMEM51 PF15345.6 AET38705.1 - 2.8 7.7 14.2 5.9 6.7 14.2 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 DUF3276 PF11680.8 AET38705.1 - 4.8 7.3 10.4 12 6.1 10.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) Pex26 PF07163.12 AET38705.1 - 5.9 6.1 10.4 11 5.3 10.4 1.3 1 0 0 1 1 1 0 Pex26 protein DUF4199 PF13858.6 AET38705.1 - 8.8 6.7 9.9 16 5.9 8.7 2.0 2 1 0 2 2 1 0 Protein of unknown function (DUF4199) PMT PF02366.18 AET38706.1 - 6.7e-21 75.0 18.5 6.7e-21 75.0 18.5 2.8 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.19 AET38706.1 - 4.2e-09 36.5 0.0 8.2e-09 35.6 0.0 1.5 1 1 0 1 1 1 1 MIR domain DUF2207 PF09972.9 AET38706.1 - 0.034 12.9 0.1 0.034 12.9 0.1 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Ins145_P3_rec PF08709.11 AET38706.1 - 0.083 12.1 0.0 0.2 10.8 0.0 1.6 1 1 0 1 1 1 0 Inositol 1,4,5-trisphosphate/ryanodine receptor DUF4131 PF13567.6 AET38706.1 - 8.6 6.0 8.6 0.26 10.9 0.5 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) Med21 PF11221.8 AET38707.1 - 8.2e-40 136.4 7.2 1e-39 136.1 7.2 1.1 1 0 0 1 1 1 1 Subunit 21 of Mediator complex Med9 PF07544.13 AET38707.1 - 0.0017 18.4 2.4 0.0043 17.1 0.3 2.7 1 1 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 Katanin_con80 PF13925.6 AET38707.1 - 0.035 14.1 0.2 0.19 11.7 0.1 1.9 2 0 0 2 2 2 0 con80 domain of Katanin Spectrin PF00435.21 AET38707.1 - 0.038 14.5 4.2 0.46 11.0 0.6 2.1 2 0 0 2 2 2 0 Spectrin repeat FliD_N PF02465.18 AET38707.1 - 0.077 13.7 1.5 0.26 12.0 0.2 2.1 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Dynamin_N PF00350.23 AET38707.1 - 0.35 10.9 2.4 0.52 10.4 2.5 1.3 1 1 0 1 1 1 0 Dynamin family Fib_alpha PF08702.10 AET38707.1 - 0.52 10.5 4.4 0.83 9.8 1.7 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family RNase_P_p30 PF01876.16 AET38710.1 - 3.5e-71 239.1 0.1 4.3e-71 238.8 0.1 1.1 1 0 0 1 1 1 1 RNase P subunit p30 Corona_S2 PF01601.16 AET38711.1 - 0.04 12.4 0.6 0.062 11.8 0.6 1.2 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Synaptobrevin PF00957.21 AET38711.1 - 0.049 13.4 0.0 0.48 10.2 0.0 2.6 2 0 0 2 2 2 0 Synaptobrevin Lectin_N PF03954.14 AET38711.1 - 2.8 7.7 5.0 1.3 8.8 0.4 2.4 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain HSP70 PF00012.20 AET38712.1 - 2.6e-75 253.8 3.2 1.9e-74 251.0 1.1 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 AET38712.1 - 1.9e-09 36.8 0.0 2.9e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein Robl_LC7 PF03259.17 AET38712.1 - 0.0028 17.4 0.5 2.2 8.1 0.1 2.7 2 0 0 2 2 2 2 Roadblock/LC7 domain DUF2603 PF10788.9 AET38712.1 - 0.006 16.6 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2603) BSD PF03909.17 AET38713.1 - 8.9e-22 76.9 4.4 2e-11 43.7 0.6 3.1 3 0 0 3 3 3 2 BSD domain PH_TFIIH PF08567.11 AET38713.1 - 1.6e-19 70.0 0.2 4e-19 68.7 0.2 1.7 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain UvrA_DNA-bind PF17755.1 AET38713.1 - 0.057 13.8 0.0 0.21 11.9 0.0 2.0 1 0 0 1 1 1 0 UvrA DNA-binding domain DEAD PF00270.29 AET38714.1 - 7e-50 169.2 0.0 1.5e-49 168.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET38714.1 - 3.7e-30 104.5 0.1 2e-29 102.1 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET38714.1 - 1.1e-06 28.8 0.0 3.5e-06 27.1 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 AET38714.1 - 0.00011 22.0 0.0 0.00036 20.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 AET38714.1 - 0.00075 19.9 0.0 0.0042 17.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain GLTP PF08718.11 AET38714.1 - 0.56 10.5 2.8 0.89 9.8 0.0 2.6 3 1 0 3 3 3 0 Glycolipid transfer protein (GLTP) Brix PF04427.18 AET38715.1 - 8.5e-51 172.8 0.4 1.4e-50 172.1 0.4 1.3 1 0 0 1 1 1 1 Brix domain DUF2514 PF10721.9 AET38715.1 - 0.0026 17.8 2.5 0.0043 17.1 2.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2514) ATP-synt_E PF05680.12 AET38715.1 - 1.4 9.3 9.0 4.5 7.7 9.0 1.9 1 0 0 1 1 1 0 ATP synthase E chain FYVE PF01363.21 AET38716.1 - 1.1e-17 64.0 12.0 1.1e-17 64.0 12.0 3.3 3 1 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.6 AET38716.1 - 1.7e-08 34.6 3.2 1.7e-08 34.6 3.2 4.3 4 1 1 5 5 5 1 Ring finger domain zf-RING_11 PF17123.5 AET38716.1 - 7.8e-06 25.5 5.2 7.8e-06 25.5 5.2 2.6 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_UBOX PF13445.6 AET38716.1 - 5.7e-05 23.1 1.4 5.7e-05 23.1 1.4 3.7 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 AET38716.1 - 7.2e-05 22.6 3.2 7.2e-05 22.6 3.2 4.7 4 1 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AET38716.1 - 0.00058 19.7 3.1 0.00058 19.7 3.1 5.1 5 1 0 5 5 4 1 Zinc finger, C3HC4 type (RING finger) Mut7-C PF01927.16 AET38716.1 - 0.0037 17.4 0.3 0.0037 17.4 0.3 3.4 4 0 0 4 4 4 1 Mut7-C RNAse domain zf-rbx1 PF12678.7 AET38716.1 - 0.01 16.1 5.6 0.01 16.1 5.6 3.7 3 2 0 3 3 2 0 RING-H2 zinc finger domain FANCL_C PF11793.8 AET38716.1 - 0.012 15.8 2.9 0.012 15.8 2.9 3.4 3 1 1 4 4 4 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.6 AET38716.1 - 0.034 14.3 2.0 0.034 14.3 2.0 4.6 4 1 1 5 5 5 0 zinc finger of C3HC4-type, RING zf-C2H2_9 PF16293.5 AET38716.1 - 0.078 12.8 2.1 1.4 8.8 0.4 2.8 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) Gp138_N PF18352.1 AET38716.1 - 0.11 12.5 0.0 0.38 10.8 0.0 1.9 1 1 0 1 1 1 0 Phage protein Gp138 N-terminal domain MaoC_dehydrat_N PF13452.6 AET38717.1 - 0.00027 21.1 0.0 0.051 13.7 0.0 2.6 3 0 0 3 3 3 2 N-terminal half of MaoC dehydratase MaoC_dehydratas PF01575.19 AET38717.1 - 0.043 13.4 0.0 0.083 12.5 0.0 1.6 1 0 0 1 1 1 0 MaoC like domain Ins_P5_2-kin PF06090.12 AET38718.1 - 5.4e-18 65.5 1.7 3.9e-16 59.4 1.7 2.1 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Thioredoxin_11 PF18078.1 AET38718.1 - 0.11 12.6 0.3 1.6 8.8 0.0 2.8 3 1 1 4 4 4 0 Thioredoxin-like SNTX domain DS PF01916.17 AET38719.1 - 3.7e-132 439.9 0.1 4.2e-132 439.7 0.1 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Methyltransf_23 PF13489.6 AET38720.1 - 7.1e-23 81.2 0.0 1.3e-22 80.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AET38720.1 - 8e-11 42.5 0.0 5e-08 33.6 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AET38720.1 - 1.3e-10 41.9 0.1 1e-09 39.0 0.0 2.6 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 AET38720.1 - 6.1e-09 36.4 0.0 0.00095 19.8 0.0 2.5 1 1 0 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 AET38720.1 - 7.8e-09 35.2 0.0 0.0014 18.0 0.0 2.3 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 AET38720.1 - 1.9e-05 24.5 0.0 6e-05 22.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain YrhC PF14143.6 AET38720.1 - 0.099 12.7 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 YrhC-like protein ECR1_N PF14382.6 AET38721.1 - 2.4e-16 59.2 0.3 5e-16 58.2 0.3 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 AET38721.1 - 1.9e-10 40.9 0.6 4e-10 39.9 0.6 1.6 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 AET38721.1 - 0.09 13.4 0.2 29 5.3 0.0 3.3 3 1 0 3 3 3 0 Exosome component EXOSC1/CSL4 Met_10 PF02475.16 AET38722.1 - 8.4e-71 237.8 0.0 1.6e-70 236.9 0.0 1.5 1 0 0 1 1 1 1 Met-10+ like-protein MethyltransfD12 PF02086.15 AET38722.1 - 0.00031 20.5 0.0 0.00056 19.7 0.0 1.3 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase TRM PF02005.16 AET38722.1 - 0.0069 15.6 0.0 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Cyclin_N PF00134.23 AET38723.1 - 9.6e-11 41.5 0.6 1.6e-10 40.8 0.6 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 AET38723.1 - 6.8e-05 23.3 0.2 6.8e-05 23.3 0.2 1.8 2 0 0 2 2 2 1 Cyclin Tenui_NS4 PF03300.13 AET38723.1 - 0.049 13.0 0.0 0.075 12.4 0.0 1.2 1 0 0 1 1 1 0 Tenuivirus non-structural, movement protein NS4 HSF_DNA-bind PF00447.17 AET38723.1 - 0.092 13.4 1.2 0.15 12.7 0.4 1.9 2 0 0 2 2 2 0 HSF-type DNA-binding DUF5341 PF17276.2 AET38724.1 - 0.0073 16.5 1.2 0.011 15.9 1.2 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5341) Vps36_ESCRT-II PF11605.8 AET38725.1 - 2.3e-31 107.8 0.6 5.1e-31 106.7 0.6 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 EAP30 PF04157.16 AET38725.1 - 4.5e-20 71.9 0.3 1.8e-19 70.0 0.3 1.9 1 1 0 1 1 1 1 EAP30/Vps36 family Vps36-NZF-N PF16988.5 AET38725.1 - 1e-15 56.9 1.8 1e-15 56.9 1.8 2.9 3 1 0 3 3 3 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain PH_TFIIH PF08567.11 AET38725.1 - 0.00017 21.8 0.0 0.00054 20.2 0.0 1.8 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain GRAM PF02893.20 AET38725.1 - 0.0015 18.4 0.1 0.012 15.5 0.0 2.3 2 0 0 2 2 2 1 GRAM domain OrfB_Zn_ribbon PF07282.11 AET38725.1 - 0.0016 18.3 3.5 0.005 16.7 0.1 2.6 1 1 1 2 2 2 1 Putative transposase DNA-binding domain bPH_3 PF14470.6 AET38725.1 - 0.0069 16.7 0.2 0.017 15.5 0.2 1.6 1 0 0 1 1 1 1 Bacterial PH domain DZR PF12773.7 AET38725.1 - 0.0079 16.2 5.0 0.045 13.8 0.8 2.4 2 0 0 2 2 2 1 Double zinc ribbon zinc_ribbon_15 PF17032.5 AET38725.1 - 0.057 14.2 3.8 0.13 13.0 3.8 1.6 1 0 0 1 1 1 0 zinc-ribbon family zf-Sec23_Sec24 PF04810.15 AET38725.1 - 0.15 12.2 0.1 0.15 12.2 0.1 3.0 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger zf-RanBP PF00641.18 AET38725.1 - 0.35 10.2 15.3 0.33 10.3 3.4 2.8 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others Ima1_N PF09779.9 AET38725.1 - 0.52 11.2 3.1 1 10.2 3.1 1.4 1 0 0 1 1 1 0 Ima1 N-terminal domain ABC_membrane_2 PF06472.15 AET38726.1 - 1.3e-58 198.5 5.8 7.8e-38 130.4 0.2 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region 2 ABC_tran PF00005.27 AET38726.1 - 1.9e-17 64.1 0.0 4.3e-17 62.9 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AET38726.1 - 8.8e-06 25.7 0.1 0.00026 20.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 AET38726.1 - 0.00035 21.1 3.0 0.011 16.3 3.0 2.8 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 AET38726.1 - 0.015 15.2 0.2 0.076 12.9 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain Phage_holin_2_1 PF04971.12 AET38726.1 - 0.017 15.1 0.7 0.42 10.6 0.2 2.5 2 0 0 2 2 2 0 Bacteriophage P21 holin S AAA_29 PF13555.6 AET38726.1 - 0.028 14.2 0.0 0.072 12.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 AET38726.1 - 0.034 13.6 0.2 0.12 11.8 0.1 1.8 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 AET38726.1 - 0.095 12.4 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 AET38726.1 - 0.097 12.9 0.0 0.33 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 AET38726.1 - 0.1 12.5 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase Mg_chelatase PF01078.21 AET38726.1 - 0.15 11.4 0.0 0.34 10.3 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI SUR7 PF06687.12 AET38727.1 - 6.1e-14 52.2 0.0 1.4e-12 47.7 0.0 2.2 1 1 0 1 1 1 1 SUR7/PalI family MscL PF01741.18 AET38727.1 - 0.025 14.9 0.0 2.2 8.6 0.0 2.6 2 0 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL GAT PF03127.14 AET38727.1 - 0.41 11.0 5.5 0.64 10.4 0.9 3.2 2 1 1 3 3 3 0 GAT domain Syndecan PF01034.20 AET38727.1 - 0.83 9.6 0.0 0.83 9.6 0.0 2.8 4 0 0 4 4 4 0 Syndecan domain Fig1 PF12351.8 AET38727.1 - 1 9.2 9.9 0.54 10.2 5.8 2.5 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 CTV_P6 PF06706.11 AET38727.1 - 1.9 8.2 4.0 35 4.2 0.1 2.7 2 0 0 2 2 2 0 Citrus tristeza virus 6-kDa protein Mtr2 PF10429.9 AET38729.1 - 2.5e-73 245.4 0.3 2.8e-73 245.2 0.3 1.0 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 GATA PF00320.27 AET38730.1 - 3.9e-08 32.8 11.4 1.2e-07 31.2 11.4 1.9 1 0 0 1 1 1 1 GATA zinc finger Orn_Arg_deC_N PF02784.16 AET38731.1 - 1.2e-75 254.1 0.0 1.7e-75 253.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 AET38731.1 - 7.8e-18 64.5 0.0 1.1e-17 64.0 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain DUF1027 PF06265.11 AET38731.1 - 0.14 12.2 0.3 0.5 10.4 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1027) Voldacs PF03517.13 AET38732.1 - 8.7e-24 84.2 0.4 8.7e-24 84.2 0.4 1.6 2 0 0 2 2 2 1 Regulator of volume decrease after cellular swelling DUF1712 PF08217.11 AET38732.1 - 0.079 11.4 0.7 0.11 11.0 0.7 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1712) DUF1729 PF08354.10 AET38733.1 - 8.5e-155 515.0 0.0 1.3e-154 514.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 AET38733.1 - 5.9e-101 338.1 0.4 5.9e-100 334.9 0.0 2.8 5 0 0 5 5 5 1 Acyl transferase domain FAS_meander PF17951.1 AET38733.1 - 2.2e-39 134.6 0.0 5.6e-39 133.3 0.0 1.8 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 AET38733.1 - 1.5e-36 126.3 0.0 5.2e-36 124.6 0.0 1.8 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydratas PF01575.19 AET38733.1 - 1.4e-35 121.5 0.0 2.9e-35 120.5 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain FAS_N PF17828.1 AET38733.1 - 2e-31 108.7 0.5 4.5e-31 107.5 0.5 1.6 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydrat_N PF13452.6 AET38733.1 - 9.5e-12 45.2 0.0 2.6e-11 43.8 0.0 1.8 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase NMO PF03060.15 AET38733.1 - 0.0096 15.3 0.0 0.094 12.1 0.0 2.4 1 1 0 1 1 1 1 Nitronate monooxygenase SRR1 PF07985.12 AET38734.1 - 2.5e-18 65.8 0.0 1.8e-17 63.1 0.0 2.2 2 0 0 2 2 2 1 SRR1 Pribosyl_synth PF14572.6 AET38735.1 - 3.9e-42 144.3 1.6 1.8e-33 116.2 0.2 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 AET38735.1 - 9.3e-40 135.2 0.1 3.1e-39 133.5 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 AET38735.1 - 9.6e-08 31.7 0.0 0.00022 20.8 0.0 2.3 2 0 0 2 2 2 2 Phosphoribosyl transferase domain UPRTase PF14681.6 AET38735.1 - 0.12 11.8 0.0 0.24 10.8 0.0 1.5 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Utp21 PF04192.12 AET38736.1 - 6.4e-73 245.1 0.0 1e-72 244.4 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain ANAPC4_WD40 PF12894.7 AET38736.1 - 7.7e-15 55.0 0.0 0.0035 17.6 0.0 6.8 4 1 2 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AET38736.1 - 1.7e-10 41.3 23.5 3.8e-07 30.7 1.3 8.3 9 0 0 9 9 9 2 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 AET38736.1 - 3.6e-05 22.5 0.0 0.00025 19.7 0.0 2.0 2 0 0 2 2 2 1 Cytochrome D1 heme domain CPSF_A PF03178.15 AET38736.1 - 0.00061 19.2 0.1 0.028 13.7 0.1 2.7 2 0 0 2 2 2 1 CPSF A subunit region eIF2A PF08662.11 AET38736.1 - 0.00092 19.1 0.0 0.019 14.8 0.0 2.8 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 AET38736.1 - 0.13 10.9 0.0 1 7.9 0.0 2.3 2 0 0 2 2 2 0 Nucleoporin Nup120/160 CBM_2 PF00553.19 AET38736.1 - 0.28 11.5 1.6 0.62 10.4 1.6 1.5 1 0 0 1 1 1 0 Cellulose binding domain Vps39_1 PF10366.9 AET38737.1 - 1.2e-34 118.8 4.2 1.2e-34 118.8 4.2 3.3 2 1 1 3 3 3 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 AET38737.1 - 1e-16 61.3 0.8 2.4e-16 60.1 0.0 2.0 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 AET38737.1 - 4.9e-06 26.5 14.8 0.0088 15.9 1.8 3.6 2 1 0 2 2 2 2 Region in Clathrin and VPS DUF496 PF04363.12 AET38737.1 - 0.021 14.8 0.4 0.021 14.8 0.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF496) GCN5L1 PF06320.13 AET38738.1 - 5.1e-08 33.1 1.2 7.2e-08 32.6 1.2 1.3 1 1 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) Syntaxin-6_N PF09177.11 AET38738.1 - 0.3 11.7 2.2 0.63 10.6 1.2 2.0 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF4050 PF13259.6 AET38739.1 - 3.9e-13 50.1 9.1 1e-10 42.2 0.4 2.6 2 1 1 3 3 3 2 Protein of unknown function (DUF4050) Rxt3 PF08642.10 AET38740.1 - 1.2e-22 81.0 0.1 3.2e-21 76.4 0.0 2.3 2 0 0 2 2 2 1 Histone deacetylation protein Rxt3 Ribosomal_L31e PF01198.19 AET38741.1 - 4.8e-40 135.7 1.0 5.9e-40 135.4 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e Dus PF01207.17 AET38742.1 - 2.4e-78 263.4 0.0 2.9e-78 263.1 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) BRE1 PF08647.11 AET38743.1 - 3.5e-27 94.3 18.9 3.5e-27 94.3 18.9 5.7 3 2 1 4 4 3 1 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.6 AET38743.1 - 2e-07 30.7 10.5 3.8e-07 29.9 10.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AET38743.1 - 7.9e-07 28.8 9.4 1.6e-06 27.9 9.4 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 AET38743.1 - 1.2e-06 28.3 11.9 2.4e-06 27.3 11.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AET38743.1 - 1.3e-05 25.0 12.6 2.7e-05 23.9 12.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AET38743.1 - 3.4e-05 23.7 12.4 6.7e-05 22.8 12.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 AET38743.1 - 0.00092 19.5 11.5 0.00092 19.5 11.5 1.8 2 0 0 2 2 2 1 Ring finger domain DUF1137 PF06587.11 AET38743.1 - 0.0039 17.2 0.2 0.024 14.7 0.5 2.3 2 0 0 2 2 1 1 Protein of unknown function (DUF1137) zf-C2H2 PF00096.26 AET38743.1 - 0.0047 17.3 0.1 0.0047 17.3 0.1 2.7 4 0 0 4 4 1 1 Zinc finger, C2H2 type zf-RING_UBOX PF13445.6 AET38743.1 - 0.0052 16.8 9.7 0.012 15.6 9.7 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C2H2_4 PF13894.6 AET38743.1 - 0.013 16.3 1.3 0.49 11.4 0.1 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger Pox_A_type_inc PF04508.12 AET38743.1 - 0.018 14.9 4.4 0.38 10.7 0.0 3.8 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat zf-C2H2_jaz PF12171.8 AET38743.1 - 0.024 14.9 1.6 0.65 10.4 0.0 2.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-RING_4 PF14570.6 AET38743.1 - 0.44 10.4 10.3 0.86 9.4 10.3 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 AET38743.1 - 2.8 8.2 9.2 7 6.9 9.2 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING SlyX PF04102.12 AET38743.1 - 3.1 8.5 0.0 0.31 11.7 2.9 6.7 6 1 1 7 7 6 0 SlyX Vir_act_alpha_C PF10400.9 AET38743.1 - 3.2 8.5 9.5 7.3 7.4 3.8 4.2 3 1 0 3 3 3 0 Virulence activator alpha C-term FYVE PF01363.21 AET38743.1 - 5.5 7.2 13.7 1.2e+02 2.9 13.8 2.8 1 1 0 1 1 1 0 FYVE zinc finger DUF1765 PF08578.10 AET38744.1 - 2.3e-21 76.5 7.0 2.3e-21 76.5 7.0 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF1765) MPM1 PF17234.2 AET38744.1 - 1.1 9.5 3.8 1 9.6 0.3 2.5 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Seipin PF06775.14 AET38745.1 - 0.053 13.6 0.2 0.35 10.9 0.1 2.2 2 1 0 2 2 2 0 Putative adipose-regulatory protein (Seipin) zf-C2H2_aberr PF17017.5 AET38746.1 - 3.5e-05 24.0 6.1 0.0021 18.3 0.4 2.6 2 0 0 2 2 2 2 Aberrant zinc-finger zf-C2H2 PF00096.26 AET38746.1 - 0.00064 20.0 17.3 0.03 14.8 1.4 4.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AET38746.1 - 0.052 14.4 0.6 0.052 14.4 0.6 5.3 5 0 0 5 5 5 0 C2H2-type zinc finger zf-met PF12874.7 AET38746.1 - 0.1 13.0 3.1 3.1 8.3 0.1 3.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 AET38746.1 - 0.18 12.3 19.3 0.2 12.1 1.7 3.7 3 0 0 3 3 3 0 Zinc-finger double domain CENP-B_dimeris PF09026.10 AET38746.1 - 0.91 10.0 14.8 2.1 8.8 14.8 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PBP1_TM PF14812.6 AET38746.1 - 2 8.8 13.3 0.37 11.2 9.4 1.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3245 PF11595.8 AET38746.1 - 4.5 7.7 13.1 3.3 8.2 5.4 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) zf-C2H2_6 PF13912.6 AET38746.1 - 5.4 7.1 10.1 3.4 7.8 1.8 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger Dus PF01207.17 AET38747.1 - 9.9e-46 156.2 0.0 7.8e-44 150.0 0.0 2.2 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-CCCH_4 PF18044.1 AET38747.1 - 0.0002 21.0 6.2 0.03 14.1 0.2 2.8 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH PF00642.24 AET38747.1 - 0.0026 17.6 0.2 0.0026 17.6 0.2 2.9 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AET38747.1 - 0.0081 16.2 4.8 0.012 15.7 0.2 2.7 2 0 0 2 2 2 1 Zinc finger domain Lustrin_cystein PF14625.6 AET38747.1 - 0.86 10.0 3.7 28 5.2 0.1 3.0 2 1 0 2 2 2 0 Lustrin, cysteine-rich repeated domain zf-CCCH_2 PF14608.6 AET38747.1 - 1.1 9.8 3.9 4.2 8.0 0.1 2.8 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Torus PF16131.5 AET38747.1 - 1.7 9.4 12.5 0.15 12.7 0.5 3.1 2 1 1 3 3 3 0 Torus domain Bap31 PF05529.12 AET38748.1 - 1.4e-38 131.8 2.3 1.8e-38 131.5 2.3 1.1 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bromodomain PF00439.25 AET38749.1 - 1e-40 137.7 0.1 4.6e-20 71.5 0.0 2.5 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 AET38749.1 - 6.4e-20 71.1 0.2 1.7e-19 69.7 0.2 1.8 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation BRCC36_C PF18110.1 AET38749.1 - 0.13 12.4 1.0 0.46 10.7 1.0 1.9 1 0 0 1 1 1 0 BRCC36 C-terminal helical domain DSHCT PF08148.12 AET38750.1 - 2.1e-45 154.3 0.4 4.6e-45 153.2 0.4 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain Ski2_N PF17911.1 AET38750.1 - 4.8e-37 126.8 0.0 1.3e-36 125.4 0.0 1.7 1 0 0 1 1 1 1 Ski2 N-terminal region DEAD PF00270.29 AET38750.1 - 8.7e-21 74.5 0.0 1.9e-20 73.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase rRNA_proc-arch PF13234.6 AET38750.1 - 4.7e-14 53.0 1.3 9.2e-14 52.0 1.3 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain Helicase_C PF00271.31 AET38750.1 - 5.6e-08 33.1 0.0 5.2e-07 30.0 0.0 2.7 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET38750.1 - 5.2e-06 26.6 0.5 1.3e-05 25.2 0.1 1.9 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit Pesticin PF16754.5 AET38750.1 - 0.23 11.4 0.6 0.75 9.7 0.1 2.1 2 0 0 2 2 2 0 Bacterial toxin homologue of phage lysozyme, C-term Ribonucleas_3_3 PF14622.6 AET38751.1 - 0.023 14.9 0.0 0.038 14.1 0.0 1.4 1 1 0 1 1 1 0 Ribonuclease-III-like AAA PF00004.29 AET38752.1 - 7.6e-88 291.7 0.0 9.6e-43 145.8 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AET38752.1 - 4.1e-18 64.9 2.5 3.3e-10 39.6 0.7 2.6 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 AET38752.1 - 1.1e-13 51.2 0.0 1.8e-05 24.6 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AET38752.1 - 6.8e-11 42.8 0.1 5.5e-05 23.6 0.0 4.0 2 2 0 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 AET38752.1 - 3.6e-10 40.2 0.0 0.00035 20.7 0.0 3.0 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 AET38752.1 - 7.6e-10 38.9 1.0 0.0013 18.7 0.0 4.2 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AET38752.1 - 1.2e-09 38.6 4.7 0.0003 21.1 0.0 5.4 3 2 2 5 5 5 2 AAA domain Rad17 PF03215.15 AET38752.1 - 6.8e-09 35.9 0.0 0.0041 17.1 0.0 2.8 2 1 0 2 2 2 2 Rad17 P-loop domain AAA_14 PF13173.6 AET38752.1 - 6.1e-08 32.8 0.0 0.00063 19.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 AET38752.1 - 1.9e-07 31.3 0.0 0.00071 19.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain CDC48_N PF02359.18 AET38752.1 - 1.5e-06 28.3 0.0 4e-06 26.9 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain Bac_DnaA PF00308.18 AET38752.1 - 7.8e-06 25.9 0.0 0.005 16.7 0.0 2.5 2 0 0 2 2 2 1 Bacterial dnaA protein Mg_chelatase PF01078.21 AET38752.1 - 2.9e-05 23.6 0.3 0.092 12.1 0.1 2.7 3 0 0 3 3 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 AET38752.1 - 3.1e-05 24.3 0.0 0.2 12.0 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.6 AET38752.1 - 6.5e-05 23.2 0.0 0.3 11.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_11 PF13086.6 AET38752.1 - 0.00012 22.0 0.1 0.13 12.1 0.0 2.9 3 0 0 3 3 3 1 AAA domain TIP49 PF06068.13 AET38752.1 - 0.00014 21.2 0.0 0.22 10.7 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain NACHT PF05729.12 AET38752.1 - 0.00014 21.8 0.2 0.14 12.0 0.0 3.9 4 0 0 4 4 4 1 NACHT domain TniB PF05621.11 AET38752.1 - 0.00026 20.5 0.0 6.8 6.0 0.0 4.4 4 1 1 5 5 5 0 Bacterial TniB protein AAA_24 PF13479.6 AET38752.1 - 0.00045 20.0 0.0 0.3 10.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 AET38752.1 - 0.00047 20.0 0.0 1.8 8.4 0.0 3.4 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 AET38752.1 - 0.00049 20.6 0.0 0.4 11.2 0.0 3.0 3 1 0 3 3 2 1 AAA domain AAA_25 PF13481.6 AET38752.1 - 0.00052 19.6 5.7 2.6 7.6 0.0 4.3 2 2 0 4 4 4 1 AAA domain ATPase_2 PF01637.18 AET38752.1 - 0.00094 19.2 0.3 2.5 7.9 0.1 3.5 2 2 0 2 2 2 1 ATPase domain predominantly from Archaea ABC_tran PF00005.27 AET38752.1 - 0.0014 19.2 0.0 0.066 13.7 0.0 2.8 2 0 0 2 2 2 1 ABC transporter TsaE PF02367.17 AET38752.1 - 0.0022 18.0 0.0 0.29 11.2 0.0 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 AET38752.1 - 0.0024 17.6 0.0 1 9.0 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_19 PF13245.6 AET38752.1 - 0.0029 18.0 0.6 0.11 12.8 0.0 2.8 2 2 0 2 2 2 1 AAA domain Vps4_C PF09336.10 AET38752.1 - 0.01 15.8 0.1 2.9 8.0 0.0 2.8 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain AAA_7 PF12775.7 AET38752.1 - 0.012 15.1 0.0 3 7.3 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 AET38752.1 - 0.013 15.2 0.0 0.33 10.6 0.0 2.6 2 1 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 AET38752.1 - 0.017 14.9 0.0 0.12 12.1 0.0 2.3 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase ATPase PF06745.13 AET38752.1 - 0.032 13.6 1.2 6.4 6.0 0.0 3.8 3 1 0 4 4 4 0 KaiC Sigma54_activ_2 PF14532.6 AET38752.1 - 0.032 14.3 0.0 1.8 8.7 0.0 2.9 3 0 0 3 3 2 0 Sigma-54 interaction domain Sigma54_activat PF00158.26 AET38752.1 - 0.055 13.2 0.0 17 5.1 0.0 3.8 3 1 0 3 3 3 0 Sigma-54 interaction domain AFG1_ATPase PF03969.16 AET38752.1 - 0.056 12.3 0.0 0.39 9.6 0.0 2.1 2 0 0 2 2 2 0 AFG1-like ATPase DUF815 PF05673.13 AET38752.1 - 0.064 12.4 0.0 2.9 7.0 0.0 2.7 2 2 1 3 3 3 0 Protein of unknown function (DUF815) Sec1 PF00995.23 AET38753.1 - 7.9e-79 266.4 5.6 1.2e-78 265.8 5.6 1.2 1 1 0 1 1 1 1 Sec1 family COX7C PF02935.16 AET38755.1 - 4.9e-24 84.4 1.8 5.8e-24 84.1 1.8 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc zf-RING_5 PF14634.6 AET38756.1 - 5.9e-09 35.7 6.1 5.9e-09 35.7 6.1 2.0 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 AET38756.1 - 0.00084 19.2 10.0 0.0037 17.1 6.7 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 THOC7 PF05615.13 AET38756.1 - 0.0091 16.3 0.1 0.018 15.4 0.1 1.4 1 0 0 1 1 1 1 Tho complex subunit 7 zf-RING_6 PF14835.6 AET38756.1 - 0.18 11.7 1.8 0.39 10.6 1.8 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.6 AET38756.1 - 0.25 11.4 4.9 2.8 8.0 2.0 3.1 2 1 1 3 3 3 0 RING-type zinc-finger zinc_ribbon_4 PF13717.6 AET38756.1 - 0.48 10.4 4.1 2.2 8.3 0.8 2.8 2 0 0 2 2 2 0 zinc-ribbon domain zf-C3HC4_3 PF13920.6 AET38756.1 - 6.7 6.7 10.4 1.1 9.1 5.5 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Aldo_ket_red PF00248.21 AET38757.1 - 7.9e-30 104.1 0.1 6e-29 101.2 0.1 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family Iso_dh PF00180.20 AET38758.1 - 1.1e-68 232.0 0.0 1.3e-68 231.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase NTP_transf_6 PF06042.11 AET38758.1 - 0.097 12.5 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 Nucleotidyltransferase ATP-synt_10 PF05176.14 AET38759.1 - 2.3e-101 338.4 0.0 2.6e-101 338.2 0.0 1.0 1 0 0 1 1 1 1 ATP10 protein Arrestin_N PF00339.29 AET38760.1 - 4.4e-06 26.8 0.1 1.3e-05 25.2 0.1 1.8 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Leg1 PF05612.12 AET38760.1 - 0.078 12.1 0.1 0.12 11.5 0.1 1.2 1 0 0 1 1 1 0 Leg1 CFEM PF05730.11 AET38761.1 - 2.1e-09 37.3 11.2 4.6e-09 36.2 11.2 1.6 1 0 0 1 1 1 1 CFEM domain Toxin_3 PF00537.18 AET38761.1 - 0.0043 17.2 3.4 0.049 13.8 1.2 2.3 2 0 0 2 2 2 1 Scorpion toxin-like domain DUF3924 PF13062.6 AET38761.1 - 1.3 9.0 3.8 1 9.4 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3924) Tmemb_cc2 PF10267.9 AET38761.1 - 2.8 7.0 8.6 3.4 6.7 8.6 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Apt1 PF10351.9 AET38761.1 - 2.9 6.6 12.3 3.5 6.4 12.3 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Hamartin PF04388.12 AET38761.1 - 8 5.0 15.2 8.7 4.9 15.2 1.0 1 0 0 1 1 1 0 Hamartin protein Pex19 PF04614.12 AET38762.1 - 1.4e-59 201.8 19.8 2.1e-59 201.3 19.8 1.2 1 0 0 1 1 1 1 Pex19 protein family NACHT_N PF17100.5 AET38762.1 - 0.032 14.1 1.0 0.032 14.1 1.0 2.2 1 1 0 2 2 2 0 N-terminal domain of NWD NACHT-NTPase Helo_like_N PF17111.5 AET38762.1 - 0.046 13.1 6.3 0.045 13.1 1.1 3.0 3 1 0 3 3 3 0 Fungal N-terminal domain of STAND proteins phage_tail_N PF08400.10 AET38762.1 - 0.056 13.4 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 Prophage tail fibre N-terminal DASH_Dad4 PF08650.10 AET38762.1 - 0.26 11.3 5.8 1 9.3 0.2 3.3 3 1 0 3 3 3 0 DASH complex subunit Dad4 GET2 PF08690.10 AET38762.1 - 1.8 8.2 24.0 0.65 9.6 11.0 2.5 1 1 2 3 3 3 0 GET complex subunit GET2 PP2C_C PF07830.13 AET38762.1 - 3.1 8.3 6.3 1.7 9.2 0.9 3.2 3 2 0 3 3 3 0 Protein serine/threonine phosphatase 2C, C-terminal domain UQ_con PF00179.26 AET38763.1 - 4.3e-45 152.8 0.2 4.8e-45 152.6 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AET38763.1 - 5.9e-05 22.8 0.0 6.8e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 AET38763.1 - 0.11 12.7 1.6 0.18 12.1 1.6 1.7 1 1 0 1 1 1 0 RWD domain Laminin_II PF06009.12 AET38764.1 - 0.13 12.3 2.6 0.42 10.6 2.6 1.9 1 0 0 1 1 1 0 Laminin Domain II FeoB_N PF02421.18 AET38764.1 - 0.88 9.1 5.3 1.3 8.6 3.8 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B Beta-lactamase PF00144.24 AET38765.1 - 0.066 12.4 0.0 0.076 12.2 0.0 1.1 1 0 0 1 1 1 0 Beta-lactamase Peptidase_M16_M PF16187.5 AET38766.1 - 1.5e-89 300.0 3.3 1.5e-89 300.0 3.3 1.7 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 AET38766.1 - 1.2e-38 132.4 1.7 5.5e-38 130.3 0.1 2.5 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 AET38766.1 - 1.3e-31 110.1 4.3 6.6e-19 68.6 0.1 3.3 3 0 0 3 3 3 2 Peptidase M16 inactive domain Ribosomal_S14 PF00253.21 AET38767.1 - 4.5e-17 61.6 2.1 4.9e-17 61.4 2.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e RIBIOP_C PF04950.12 AET38768.1 - 1.3e-103 346.5 0.0 2e-103 345.9 0.0 1.3 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 AET38768.1 - 2.1e-19 69.4 0.0 4e-19 68.5 0.0 1.5 1 0 0 1 1 1 1 AARP2CN (NUC121) domain zf-C2H2_2 PF12756.7 AET38769.1 - 1.2e-29 102.6 12.0 1.9e-29 102.0 0.2 2.9 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 AET38769.1 - 0.088 13.1 6.1 0.29 11.5 1.2 3.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 AET38769.1 - 7.2 7.7 10.7 2.7 9.1 0.5 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger Vac14_Fig4_bd PF11916.8 AET38770.1 - 3e-68 229.0 4.3 8e-68 227.6 4.3 1.8 1 0 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 AET38770.1 - 5.2e-45 152.0 6.7 6e-39 132.6 0.2 4.3 5 0 0 5 5 4 2 Vacuolar 14 Fab1-binding region HEAT PF02985.22 AET38770.1 - 1.9e-12 46.3 3.1 0.0013 18.8 0.0 6.8 6 0 0 6 6 6 3 HEAT repeat CLASP_N PF12348.8 AET38770.1 - 3.1e-08 33.5 2.9 0.0013 18.4 0.3 4.3 3 1 1 4 4 4 3 CLASP N terminal HEAT_2 PF13646.6 AET38770.1 - 8.8e-08 32.4 0.0 0.13 12.7 0.0 5.8 4 3 3 7 7 7 1 HEAT repeats Cnd1 PF12717.7 AET38770.1 - 4.5e-05 23.5 8.7 0.23 11.5 0.9 4.2 3 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Tti2 PF10521.9 AET38770.1 - 0.0002 21.0 5.5 3.2 7.2 0.1 4.6 4 1 0 4 4 4 2 Tti2 family HEAT_EZ PF13513.6 AET38770.1 - 0.00042 20.7 3.9 0.17 12.4 0.1 4.7 6 1 1 7 7 6 1 HEAT-like repeat Arm PF00514.23 AET38770.1 - 0.0059 16.6 4.3 5.6 7.2 0.0 4.7 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat RIX1 PF08167.12 AET38770.1 - 0.015 15.1 4.8 0.052 13.3 0.2 3.3 3 1 0 3 3 3 0 rRNA processing/ribosome biogenesis Thioredoxin_4 PF13462.6 AET38770.1 - 0.017 15.3 1.8 0.034 14.3 0.4 2.2 3 0 0 3 3 3 0 Thioredoxin DUF3361 PF11841.8 AET38770.1 - 0.03 14.2 1.8 2.4 8.1 0.2 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF3361) RTP1_C1 PF10363.9 AET38770.1 - 0.1 12.8 7.2 8.4 6.6 0.1 4.9 4 2 1 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 RasGEF_N_2 PF14663.6 AET38770.1 - 1.4 9.4 6.7 2 8.8 0.1 4.1 4 1 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain TAF6_C PF07571.13 AET38770.1 - 1.8 9.0 3.6 3.6 8.0 0.1 3.4 4 1 0 4 4 3 0 TAF6 C-terminal HEAT repeat domain SWC7 PF17330.2 AET38771.1 - 1.3e-40 137.4 0.8 1.7e-40 137.0 0.8 1.2 1 0 0 1 1 1 1 SWR1 chromatin-remodelling complex, sub-unit Swc7 IKI3 PF04762.12 AET38772.1 - 0 1125.3 0.8 0 1125.0 0.1 1.5 2 0 0 2 2 2 1 IKI3 family ANAPC4_WD40 PF12894.7 AET38772.1 - 0.005 17.1 1.2 3.8 7.9 0.2 4.0 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain SWIB PF02201.18 AET38772.1 - 0.063 13.2 1.1 6.4 6.7 0.1 2.7 2 0 0 2 2 2 0 SWIB/MDM2 domain Rad52_Rad22 PF04098.15 AET38773.1 - 9.5e-41 139.3 0.2 1.2e-40 139.0 0.2 1.1 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein RC-P840_PscD PF10657.9 AET38773.1 - 0.011 15.8 0.1 4.7 7.3 0.0 2.2 2 0 0 2 2 2 0 Photosystem P840 reaction centre protein PscD DnaJ_C PF01556.18 AET38774.1 - 2.7e-40 137.9 0.2 3.4e-40 137.5 0.2 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AET38774.1 - 7e-25 86.9 3.0 1.2e-24 86.2 3.0 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 AET38774.1 - 4.8e-16 58.9 18.2 1e-15 57.8 18.2 1.6 1 0 0 1 1 1 1 DnaJ central domain Malate_DH PF12434.8 AET38774.1 - 0.041 13.9 0.4 0.093 12.8 0.4 1.6 1 0 0 1 1 1 0 Malate dehydrogenase enzyme LprI PF07007.12 AET38774.1 - 0.096 13.4 0.0 0.22 12.2 0.0 1.5 1 0 0 1 1 1 0 Lysozyme inhibitor LprI HypA PF01155.19 AET38774.1 - 0.23 11.5 10.8 1.1 9.2 1.6 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Anti-TRAP PF15777.5 AET38774.1 - 0.34 10.9 17.2 0.23 11.4 3.6 2.5 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein RseC_MucC PF04246.12 AET38774.1 - 2.3 8.2 7.1 0.53 10.2 1.1 2.3 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC MTS PF05175.14 AET38775.1 - 1.2e-09 38.0 0.0 2e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 AET38775.1 - 8.5e-08 32.8 0.0 1.7e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AET38775.1 - 2.8e-07 30.5 0.0 4.8e-07 29.7 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 AET38775.1 - 0.00021 20.8 0.2 0.00033 20.2 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 AET38775.1 - 0.0012 18.7 0.0 0.0018 18.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 AET38775.1 - 0.0026 17.4 0.0 0.0041 16.8 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 AET38775.1 - 0.0069 17.0 0.0 0.017 15.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AET38775.1 - 0.01 16.6 0.0 0.018 15.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_10 PF05971.12 AET38775.1 - 0.01 15.2 0.0 0.015 14.7 0.0 1.1 1 0 0 1 1 1 0 RNA methyltransferase Ubie_methyltran PF01209.18 AET38775.1 - 0.058 12.7 0.0 0.12 11.7 0.0 1.4 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family UPF0020 PF01170.18 AET38775.1 - 0.08 12.6 0.0 0.36 10.5 0.0 1.8 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 Methyltr_RsmB-F PF01189.17 AET38775.1 - 0.18 11.4 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F AviRa PF11599.8 AET38775.1 - 0.2 11.1 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Gcd10p PF04189.13 AET38776.1 - 6.2e-97 324.3 0.2 1e-96 323.6 0.2 1.3 1 0 0 1 1 1 1 Gcd10p family CNP_C_terminal PF17839.1 AET38776.1 - 8.6 7.1 7.9 0.32 11.8 0.3 2.6 3 1 0 3 3 3 0 C-terminal domain of cyclic nucleotide phosphodiesterase Methyltr_RsmB-F PF01189.17 AET38777.1 - 5.7e-82 274.2 0.0 1.2e-81 273.2 0.0 1.6 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 AET38777.1 - 3.6e-08 33.8 0.0 2.3e-07 31.2 0.0 2.4 2 0 0 2 2 2 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 AET38777.1 - 0.0086 16.2 0.0 0.021 15.0 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase Actin PF00022.19 AET38778.1 - 2.3e-46 158.3 0.3 7.5e-27 94.0 0.0 2.3 2 0 0 2 2 2 2 Actin MreB_Mbl PF06723.13 AET38778.1 - 0.0033 16.3 0.0 0.016 14.1 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Nop25 PF09805.9 AET38778.1 - 0.02 15.4 8.8 0.02 15.4 8.8 3.4 2 1 1 3 3 3 0 Nucleolar protein 12 (25kDa) Ras PF00071.22 AET38779.1 - 1.6e-56 190.3 0.0 1.9e-56 190.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET38779.1 - 1.3e-22 80.3 0.0 1.8e-22 79.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET38779.1 - 1.5e-08 34.3 0.0 2.6e-08 33.5 0.0 1.3 2 0 0 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.10 AET38779.1 - 0.0013 18.2 0.0 0.0018 17.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 AET38779.1 - 0.0054 15.9 0.0 0.0055 15.9 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit MMR_HSR1 PF01926.23 AET38779.1 - 0.0084 16.2 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 AET38779.1 - 0.0094 15.3 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 AET38779.1 - 0.026 13.4 0.1 0.043 12.7 0.1 1.5 1 1 0 1 1 1 0 Dynein light intermediate chain (DLIC) ABC_tran PF00005.27 AET38779.1 - 0.067 13.7 0.0 0.097 13.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter PMP1_2 PF08114.11 AET38780.1 - 0.14 11.9 0.2 0.24 11.2 0.2 1.3 1 0 0 1 1 1 0 ATPase proteolipid family Y_phosphatase2 PF03162.13 AET38782.1 - 4.5e-53 179.2 0.0 5.2e-53 179.0 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 AET38782.1 - 6.7e-06 26.2 0.0 8.3e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 AET38782.1 - 0.028 14.2 0.0 0.04 13.7 0.0 1.2 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Arginase PF00491.21 AET38782.1 - 0.098 12.1 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Arginase family Aminotran_1_2 PF00155.21 AET38783.1 - 3.5e-55 187.6 0.0 4.2e-55 187.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 AET38783.1 - 0.0011 17.8 0.0 0.0017 17.2 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase NUP214 PF16755.5 AET38784.1 - 1.2e-78 264.9 0.8 1.2e-78 264.9 0.8 1.9 2 0 0 2 2 2 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 GAS PF13851.6 AET38784.1 - 0.0056 16.1 2.8 0.015 14.7 1.8 2.2 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding Porin_3 PF01459.22 AET38785.1 - 6.4e-70 235.7 0.3 7.2e-70 235.5 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic porin Vac7 PF12751.7 AET38786.1 - 5.1e-30 105.2 9.8 7.4e-21 75.0 1.0 3.7 3 0 0 3 3 3 2 Vacuolar segregation subunit 7 DSPc PF00782.20 AET38787.1 - 4.8e-37 126.7 0.7 4.8e-37 126.7 0.7 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AET38787.1 - 0.00052 19.6 3.7 0.0015 18.1 0.0 2.6 3 0 0 3 3 3 1 Protein-tyrosine phosphatase DSPn PF14671.6 AET38787.1 - 0.0034 17.9 0.1 0.0034 17.9 0.1 1.8 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half PTPlike_phytase PF14566.6 AET38787.1 - 0.079 13.1 0.5 0.76 9.9 0.0 2.3 2 0 0 2 2 2 0 Inositol hexakisphosphate Init_tRNA_PT PF04179.12 AET38787.1 - 0.14 12.4 1.7 0.14 12.4 0.1 1.8 2 0 0 2 2 2 0 Rit1 DUSP-like domain Wax2_C PF12076.8 AET38787.1 - 0.14 11.8 0.1 0.29 10.9 0.1 1.4 1 0 0 1 1 1 0 WAX2 C-terminal domain COX4 PF02936.14 AET38788.1 - 5.1e-35 120.5 0.4 5.9e-35 120.3 0.4 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV B12D PF06522.11 AET38788.1 - 0.092 12.6 2.3 10 6.0 0.0 3.1 3 1 0 3 3 3 0 NADH-ubiquinone reductase complex 1 MLRQ subunit Methyltransf_16 PF10294.9 AET38789.1 - 0.016 15.0 0.1 0.72 9.6 0.0 2.3 2 0 0 2 2 2 0 Lysine methyltransferase COG5 PF10392.9 AET38790.1 - 1.6e-38 131.9 2.8 1.6e-38 131.9 2.8 2.7 3 1 0 3 3 3 1 Golgi transport complex subunit 5 DUF2011 PF09428.10 AET38791.1 - 6.1e-17 61.6 0.1 9.8e-17 61.0 0.1 1.3 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2011) Sec23_trunk PF04811.15 AET38792.1 - 9.5e-71 238.2 0.0 2.1e-70 237.0 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 AET38792.1 - 2.1e-19 69.2 0.0 5.2e-19 68.0 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 AET38792.1 - 3.3e-17 62.2 2.4 7.1e-17 61.2 2.4 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 AET38792.1 - 1.2e-16 61.3 1.5 1.8e-15 57.4 0.0 3.2 4 0 0 4 4 4 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 AET38792.1 - 1.2e-10 41.1 0.0 2.5e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 AET38792.1 - 0.11 11.9 0.0 0.25 10.7 0.0 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Metallopep PF12044.8 AET38793.1 - 2.7e-166 553.5 0.0 4.4e-166 552.7 0.0 1.3 2 0 0 2 2 2 1 Putative peptidase family Jacalin PF01419.17 AET38793.1 - 9.4e-07 28.8 0.4 7.1e-06 26.0 0.1 2.5 2 1 0 2 2 2 1 Jacalin-like lectin domain Reprolysin_3 PF13582.6 AET38793.1 - 0.026 15.0 0.0 0.062 13.8 0.0 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 AET38793.1 - 0.046 13.3 0.0 0.083 12.5 0.0 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Reprolysin_5 PF13688.6 AET38793.1 - 0.064 13.4 0.1 0.12 12.5 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M66 PF10462.9 AET38793.1 - 0.14 11.1 0.0 0.29 10.0 0.0 1.5 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M10 PF00413.24 AET38793.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Matrixin Mob1_phocein PF03637.17 AET38794.1 - 1.2e-66 223.9 0.8 1.6e-66 223.5 0.8 1.1 1 0 0 1 1 1 1 Mob1/phocein family ALG11_N PF15924.5 AET38795.1 - 2e-79 266.5 0.3 2.9e-79 266.0 0.3 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 AET38795.1 - 3e-13 49.7 0.0 7.2e-13 48.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AET38795.1 - 4.4e-05 23.9 0.0 9.2e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 AET38795.1 - 0.0043 17.1 0.1 0.0074 16.3 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 PH PF00169.29 AET38796.1 - 5.3e-11 43.0 0.8 1.1e-10 42.0 0.8 1.6 1 0 0 1 1 1 1 PH domain RTT107_BRCT_5 PF16770.5 AET38796.1 - 0.063 13.2 0.4 0.44 10.5 0.0 2.2 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain Peptidase_M1 PF01433.20 AET38797.1 - 1.4e-35 122.8 0.4 2.2e-35 122.2 0.4 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 AET38797.1 - 2.2e-18 67.1 0.1 3.4e-18 66.5 0.1 1.2 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Leuk-A4-hydro_C PF09127.11 AET38797.1 - 2.8e-13 50.0 0.5 8.7e-13 48.3 0.1 2.1 2 0 0 2 2 2 1 Leukotriene A4 hydrolase, C-terminal PRA1 PF03208.19 AET38798.1 - 2.8e-40 137.2 3.8 3.4e-40 137.0 3.8 1.0 1 0 0 1 1 1 1 PRA1 family protein DUF2207 PF09972.9 AET38798.1 - 0.27 10.0 7.4 1.3 7.7 7.4 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2722 PF10846.8 AET38799.1 - 8.1e-54 183.3 21.2 8.7e-33 114.0 0.2 3.2 2 1 1 3 3 3 3 Protein of unknown function (DUF2722) SHQ1 PF04925.15 AET38800.1 - 7.6e-70 234.0 1.1 1.2e-69 233.3 1.1 1.3 1 0 0 1 1 1 1 SHQ1 protein Diphthamide_syn PF01866.17 AET38801.1 - 8.1e-113 376.8 0.0 1e-112 376.5 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein COG6 PF06419.11 AET38802.1 - 1.2e-143 479.6 20.3 1.2e-143 479.6 20.3 1.4 2 0 0 2 2 2 1 Conserved oligomeric complex COG6 MLD PF11647.8 AET38802.1 - 0.082 13.2 3.0 2.9 8.2 0.1 4.0 3 1 1 4 4 4 0 Membrane Localization Domain DASH_Dad3 PF08656.10 AET38802.1 - 1.8 8.7 4.6 25 5.0 0.0 4.0 3 1 0 3 3 3 0 DASH complex subunit Dad3 DUF2573 PF10835.8 AET38803.1 - 0.16 12.3 0.1 5.9 7.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2573) Pro_CA PF00484.19 AET38804.1 - 4.5e-37 127.7 0.1 6.1e-37 127.3 0.1 1.2 1 0 0 1 1 1 1 Carbonic anhydrase Glyco_hydro_15 PF00723.21 AET38805.1 - 1.4e-50 172.4 0.0 2.1e-50 171.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Complex1_LYR_2 PF13233.6 AET38806.1 - 3.3e-17 63.0 3.4 2.6e-16 60.1 3.4 2.1 1 1 0 1 1 1 1 Complex1_LYR-like DUF1804 PF08822.11 AET38806.1 - 0.0037 17.3 0.9 0.0054 16.7 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1804) Iso_dh PF00180.20 AET38807.1 - 3.7e-82 276.3 0.1 4.2e-82 276.1 0.1 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Pim PF16765.5 AET38807.1 - 0.06 13.5 0.1 18 5.6 0.0 2.3 2 0 0 2 2 2 0 Pesticin immunity protein CLTH PF10607.9 AET38808.1 - 5.1e-29 101.1 2.4 5.1e-29 101.1 2.4 2.2 3 1 0 3 3 3 1 CTLH/CRA C-terminal to LisH motif domain U-box PF04564.15 AET38808.1 - 0.022 14.9 0.0 0.064 13.4 0.0 1.8 1 0 0 1 1 1 0 U-box domain DUF2431 PF10354.9 AET38809.1 - 7.7e-52 175.9 0.1 1.1e-51 175.5 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) PIG-H PF10181.9 AET38810.1 - 1.7e-22 79.1 0.5 2.6e-22 78.5 0.5 1.3 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component Myb_DNA-bind_7 PF15963.5 AET38811.1 - 5.7e-28 96.6 0.2 5.7e-28 96.6 0.2 2.8 3 0 0 3 3 3 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 AET38811.1 - 4.1e-09 36.5 0.0 1.3e-08 34.9 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AET38811.1 - 0.041 14.1 0.8 0.11 12.8 0.1 2.1 2 0 0 2 2 2 0 Myb-like DNA-binding domain WD40 PF00400.32 AET38812.1 - 8e-07 29.7 7.3 0.0096 16.8 0.4 4.7 4 1 1 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET38812.1 - 0.0021 18.3 0.1 17 5.8 0.0 3.9 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.25 AET38813.1 - 1.3e-38 132.9 0.0 1.9e-38 132.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38813.1 - 1.7e-28 99.6 0.0 2.3e-28 99.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AET38813.1 - 0.0045 16.0 0.1 0.0089 15.0 0.1 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 AET38813.1 - 0.0046 16.3 0.0 0.0079 15.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AET38813.1 - 0.21 11.5 0.0 0.73 9.7 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Arb2 PF09757.9 AET38814.1 - 9.6e-91 303.5 0.0 1.3e-90 303.0 0.0 1.2 1 0 0 1 1 1 1 Arb2 domain Hist_deacetyl PF00850.19 AET38814.1 - 1.4e-88 297.4 0.0 1.8e-88 297.0 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Methyltr_RsmB-F PF01189.17 AET38815.1 - 2.6e-21 76.2 0.0 1e-13 51.4 0.0 2.3 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Iso_dh PF00180.20 AET38816.1 - 8e-103 344.2 0.0 9.8e-103 343.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Pox_C4_C10 PF03336.13 AET38816.1 - 0.041 13.0 0.1 0.059 12.5 0.1 1.1 1 0 0 1 1 1 0 Poxvirus C4/C10 protein R3H PF01424.22 AET38817.1 - 5.8e-19 67.8 0.1 1.1e-18 67.0 0.1 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 AET38817.1 - 5.3e-07 29.6 60.3 8.3e-05 22.6 14.2 11.0 8 1 0 8 8 8 3 NF-X1 type zinc finger Glutaminase PF04960.15 AET38817.1 - 0.12 11.5 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Glutaminase Methyltransf_16 PF10294.9 AET38818.1 - 4.6e-50 169.8 0.0 5.9e-50 169.4 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 AET38818.1 - 0.013 15.1 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain MRP-S25 PF13741.6 AET38819.1 - 1.2e-94 316.2 0.5 1.4e-94 316.0 0.5 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 AET38819.1 - 7.7e-07 29.4 0.2 0.00087 19.6 0.0 2.5 2 0 0 2 2 2 2 Mitochondrial ribosomal protein S23 DUF1242 PF06842.12 AET38820.1 - 1.9e-13 50.0 0.9 2.5e-13 49.6 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) UTP25 PF06862.12 AET38821.1 - 1.1e-197 657.5 12.9 1.4e-197 657.2 12.9 1.1 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 AET38821.1 - 0.00018 21.3 0.1 0.79 9.5 0.1 2.6 2 0 0 2 2 2 2 DEAD/DEAH box helicase ICE2 PF08426.10 AET38822.1 - 4.3e-152 506.9 33.5 5.1e-152 506.7 33.5 1.0 1 0 0 1 1 1 1 ICE2 Cyclin_N PF00134.23 AET38823.1 - 4.7e-17 61.9 0.4 2.5e-16 59.6 0.1 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 AET38823.1 - 1e-05 25.9 0.2 2.9e-05 24.4 0.2 1.8 1 1 0 1 1 1 1 Cyclin C-terminal domain TRAM_LAG1_CLN8 PF03798.16 AET38824.1 - 1e-43 149.4 28.0 1e-43 149.4 28.0 1.8 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 AET38824.1 - 1.2e-15 56.9 1.0 1.2e-15 56.9 1.0 2.7 2 0 0 2 2 2 1 TRAM1-like protein Aa_trans PF01490.18 AET38825.1 - 1.7e-95 320.1 18.6 2e-95 319.9 18.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PepSY_TM PF03929.16 AET38825.1 - 0.0022 17.7 1.2 0.0022 17.7 1.2 1.9 2 0 0 2 2 2 1 PepSY-associated TM region Y_phosphatase2 PF03162.13 AET38826.1 - 5.1e-63 211.6 0.5 6.5e-63 211.2 0.1 1.4 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 AET38826.1 - 2.9e-06 27.4 0.0 5.1e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 AET38826.1 - 0.0011 18.8 0.1 0.0028 17.5 0.0 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AET38826.1 - 0.003 17.2 0.9 0.0068 16.0 0.0 1.8 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Aim19 PF10315.9 AET38827.1 - 1e-37 129.0 2.5 1.2e-37 128.8 2.5 1.0 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 19 Histone PF00125.24 AET38828.1 - 3.1e-49 166.7 3.4 3.4e-49 166.5 3.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 AET38828.1 - 2e-06 28.1 0.0 3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 AET38828.1 - 5.5e-05 23.8 1.3 6.9e-05 23.5 1.3 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 AET38828.1 - 0.00011 22.3 0.8 0.00015 21.9 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 AET38828.1 - 0.0018 18.5 0.9 0.0023 18.2 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 AET38828.1 - 0.035 14.2 0.2 0.058 13.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 AET38829.1 - 1.5e-09 37.9 0.1 1.9e-09 37.6 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 AET38829.1 - 2e-05 24.9 0.1 2.4e-05 24.7 0.1 1.2 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 AET38829.1 - 4.5e-05 23.5 0.2 6.7e-05 23.0 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 AET38829.1 - 0.0001 22.5 0.1 0.00019 21.6 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 AET38829.1 - 0.00019 21.7 0.1 0.00027 21.3 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 AET38829.1 - 0.003 17.6 0.0 0.0036 17.4 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 AET38829.1 - 0.0066 16.4 0.0 0.0097 15.9 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.13 AET38829.1 - 0.04 14.4 0.2 0.069 13.7 0.1 1.4 1 1 0 1 1 1 0 Transcription initiation factor TFIID subunit A zf-C2H2 PF00096.26 AET38830.1 - 3.4e-13 49.3 13.6 1.5e-06 28.3 2.7 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AET38830.1 - 6.6e-12 45.3 10.0 2.5e-06 27.6 0.4 4.0 3 1 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 AET38830.1 - 8.3e-08 32.4 14.3 0.00077 20.1 1.5 4.1 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.7 AET38830.1 - 5.2e-06 26.7 4.5 3.2e-05 24.2 0.7 2.8 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 AET38830.1 - 8.2e-06 25.7 5.8 0.0018 18.2 0.3 3.6 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AET38830.1 - 4.2e-05 23.7 7.0 0.0055 17.0 0.7 3.3 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding Zn_ribbon_recom PF13408.6 AET38830.1 - 0.0017 18.8 2.5 0.0017 18.8 2.5 2.0 2 0 0 2 2 2 1 Recombinase zinc beta ribbon domain Ino80_Iec3 PF14612.6 AET38830.1 - 0.025 15.3 0.4 0.025 15.3 0.4 2.1 2 1 0 2 2 2 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling FYVE PF01363.21 AET38830.1 - 0.095 12.9 4.4 0.22 11.7 4.4 1.6 1 0 0 1 1 1 0 FYVE zinc finger zf_UBZ PF18439.1 AET38830.1 - 0.11 12.1 3.3 3.8 7.2 0.3 3.0 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-C2H2_11 PF16622.5 AET38830.1 - 0.31 10.8 3.3 36 4.2 0.3 3.5 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-BED PF02892.15 AET38830.1 - 0.53 10.3 5.3 3 7.9 0.4 3.0 2 1 1 3 3 3 0 BED zinc finger Zn-ribbon_8 PF09723.10 AET38830.1 - 0.62 10.2 2.1 1.4 9.0 0.9 2.3 2 1 1 3 3 3 0 Zinc ribbon domain zf-AN1 PF01428.16 AET38830.1 - 1 9.6 5.2 4.9 7.4 1.2 2.4 2 0 0 2 2 2 0 AN1-like Zinc finger Bac_surface_Ag PF01103.23 AET38831.1 - 8.4e-50 170.1 5.8 1.1e-49 169.7 5.8 1.1 1 0 0 1 1 1 1 Surface antigen DFP PF04127.15 AET38832.1 - 6.3e-16 58.7 0.0 2.3e-06 27.6 0.0 3.1 2 1 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein RRM_1 PF00076.22 AET38833.1 - 9e-51 169.6 0.7 2.2e-18 65.8 0.2 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AET38833.1 - 1.4e-08 34.5 0.0 0.00087 19.1 0.0 2.5 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_5 PF13893.6 AET38833.1 - 0.0004 20.0 0.0 0.0016 18.0 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AET38833.1 - 0.0029 17.7 0.6 0.24 11.5 0.1 3.5 3 1 1 4 4 4 1 RNA recognition motif PHM7_cyt PF14703.6 AET38833.1 - 0.011 16.0 0.6 5.7 7.1 0.0 3.0 3 1 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM_2 PF14605.6 AET38833.1 - 0.042 13.9 0.2 0.85 9.7 0.1 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Frataxin_Cyay PF01491.16 AET38835.1 - 2.2e-36 124.2 0.0 6.5e-36 122.7 0.0 1.6 2 0 0 2 2 2 1 Frataxin-like domain CPSase_sm_chain PF00988.22 AET38835.1 - 0.0074 16.1 0.0 0.016 15.0 0.0 1.5 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain Inhibitor_I9 PF05922.16 AET38836.1 - 0.032 14.9 0.2 1.9 9.2 0.2 2.5 1 1 0 1 1 1 0 Peptidase inhibitor I9 Glyco_hydro_38N PF01074.22 AET38837.1 - 5.4e-77 259.0 1.6 1.1e-75 254.7 0.6 2.2 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 AET38837.1 - 2e-51 175.1 0.6 3e-51 174.5 0.6 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 AET38837.1 - 4.5e-24 84.4 0.0 9.1e-24 83.4 0.0 1.5 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 AET38837.1 - 9.1e-09 35.3 0.1 5.1e-08 32.9 0.1 2.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain DUF4968 PF16338.5 AET38837.1 - 0.018 15.3 0.1 0.043 14.1 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4968) Prenyltrans PF00432.21 AET38838.1 - 2.1e-32 110.5 0.3 7.9e-07 28.7 0.0 4.7 4 0 0 4 4 4 4 Prenyltransferase and squalene oxidase repeat MsyB PF13984.6 AET38838.1 - 0.0092 16.3 0.0 0.016 15.5 0.0 1.3 1 0 0 1 1 1 1 MsyB protein Mito_carr PF00153.27 AET38839.1 - 1.1e-48 163.0 8.1 4.7e-19 68.1 0.1 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 AET38839.1 - 0.0015 17.7 2.7 0.01 15.0 0.2 2.8 2 1 1 3 3 3 1 Gammaproteobacterial serine protease DUF3433 PF11915.8 AET38839.1 - 0.12 12.9 0.1 0.31 11.5 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3433) ACPS PF01648.20 AET38840.1 - 2.3e-12 47.1 0.0 3.7e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Pex14_N PF04695.13 AET38841.1 - 9.6e-27 94.6 3.0 9.6e-27 94.6 3.0 3.3 2 2 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF812 PF05667.11 AET38841.1 - 0.0013 17.7 3.5 0.0018 17.2 3.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF1043 PF06295.12 AET38841.1 - 0.0022 18.0 5.8 0.0022 18.0 5.8 3.6 3 1 1 4 4 4 1 Protein of unknown function (DUF1043) ALIX_LYPXL_bnd PF13949.6 AET38841.1 - 0.0031 16.8 5.0 0.006 15.9 5.0 1.6 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV COR PF16095.5 AET38841.1 - 0.0034 17.2 0.3 0.0063 16.4 0.0 1.6 2 0 0 2 2 1 1 C-terminal of Roc, COR, domain Exonuc_VII_L PF02601.15 AET38841.1 - 0.011 15.3 1.4 0.014 15.0 1.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spc7 PF08317.11 AET38841.1 - 0.017 14.0 12.4 0.043 12.7 12.4 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 AET38841.1 - 0.026 13.9 0.2 0.032 13.6 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Laminin_II PF06009.12 AET38841.1 - 0.03 14.3 7.6 0.064 13.3 6.7 2.0 2 0 0 2 2 2 0 Laminin Domain II DUF1664 PF07889.12 AET38841.1 - 0.044 13.8 6.4 2.2 8.3 5.7 2.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) GTP-bdg_M PF16360.5 AET38841.1 - 0.075 13.6 6.5 0.6 10.7 0.7 3.0 2 1 0 2 2 2 0 GTP-binding GTPase Middle Region MbeD_MobD PF04899.12 AET38841.1 - 0.076 13.1 1.3 0.24 11.5 1.3 1.9 1 0 0 1 1 1 0 MbeD/MobD like Acyltransf_C PF16076.5 AET38841.1 - 0.13 12.4 1.1 0.35 11.0 1.1 1.7 1 0 0 1 1 1 0 Acyltransferase C-terminus ECH_2 PF16113.5 AET38841.1 - 0.17 11.3 3.0 0.32 10.5 1.7 2.0 1 1 1 2 2 2 0 Enoyl-CoA hydratase/isomerase Phage_GPO PF05929.11 AET38841.1 - 0.47 10.0 7.3 0.9 9.1 7.3 1.4 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase UPF0242 PF06785.11 AET38841.1 - 0.54 10.3 10.6 0.18 11.9 7.6 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus HAP1_N PF04849.13 AET38841.1 - 0.79 8.9 13.9 1.4 8.0 14.0 1.4 1 1 0 1 1 1 0 HAP1 N-terminal conserved region Atg14 PF10186.9 AET38841.1 - 0.9 8.6 7.8 1.8 7.6 7.8 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Occludin_ELL PF07303.13 AET38841.1 - 0.97 10.2 8.1 4 8.2 8.1 2.0 1 1 0 1 1 1 0 Occludin homology domain FliJ PF02050.16 AET38841.1 - 1.2 9.4 11.7 0.68 10.2 7.5 2.5 2 1 1 3 3 3 0 Flagellar FliJ protein FapA PF03961.13 AET38841.1 - 4.2 5.9 10.6 9 4.8 0.5 1.7 1 1 1 2 2 2 0 Flagellar Assembly Protein A PRP1_N PF06424.12 AET38841.1 - 6.8 7.1 8.5 57 4.1 8.5 2.4 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal Med5 PF08689.10 AET38842.1 - 0 1379.2 42.0 0 1379.0 42.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit Med5 SNF2_N PF00176.23 AET38843.1 - 5.8e-68 229.2 0.3 1.8e-67 227.5 0.3 2.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.6 AET38843.1 - 4.9e-48 162.9 20.8 4.9e-48 162.9 20.8 5.6 6 0 0 6 6 6 1 DNA-binding domain Helicase_C PF00271.31 AET38843.1 - 1.1e-17 64.3 0.2 6e-17 62.0 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Fe_hyd_lg_C PF02906.14 AET38843.1 - 0.23 11.1 3.1 0.12 12.0 0.3 2.0 2 0 0 2 2 2 0 Iron only hydrogenase large subunit, C-terminal domain Spc7 PF08317.11 AET38844.1 - 0.00077 18.4 2.7 0.00088 18.2 2.7 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein Exonuc_VII_L PF02601.15 AET38844.1 - 0.0013 18.4 0.2 0.0015 18.2 0.2 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit HIP1_clath_bdg PF16515.5 AET38844.1 - 0.0093 16.6 7.0 0.015 15.9 7.0 1.3 1 0 0 1 1 1 1 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4407 PF14362.6 AET38844.1 - 0.026 13.9 0.9 0.03 13.7 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1974 PF09317.11 AET38844.1 - 0.058 13.0 0.1 0.068 12.7 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1974) VPR PF00522.18 AET38844.1 - 0.061 13.4 0.1 0.098 12.7 0.1 1.4 1 0 0 1 1 1 0 VPR/VPX protein Prominin PF05478.11 AET38844.1 - 0.24 9.3 1.3 0.39 8.6 1.0 1.4 1 1 0 1 1 1 0 Prominin FUSC PF04632.12 AET38844.1 - 0.32 9.5 0.6 0.34 9.4 0.6 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Fib_alpha PF08702.10 AET38844.1 - 0.68 10.1 4.9 0.99 9.6 4.9 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 AET38844.1 - 1.5 8.9 4.2 2 8.5 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) EMP24_GP25L PF01105.24 AET38845.1 - 1.5e-05 25.0 0.2 0.0056 16.6 0.0 2.2 2 0 0 2 2 2 2 emp24/gp25L/p24 family/GOLD RNase_PH PF01138.21 AET38846.1 - 7.1e-09 36.3 0.0 1.3e-08 35.4 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AET38846.1 - 0.00016 21.6 0.0 0.00029 20.8 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 SpoU_methylase PF00588.19 AET38847.1 - 7.4e-26 91.0 0.0 2.2e-25 89.5 0.0 1.9 1 0 0 1 1 1 1 SpoU rRNA Methylase family Pas_Saposin PF09016.10 AET38847.1 - 0.033 14.5 0.2 1.7 9.0 0.0 3.3 3 0 0 3 3 3 0 Pas factor saposin fold Vitellogenin_N PF01347.22 AET38847.1 - 0.12 10.8 0.1 0.18 10.2 0.1 1.2 1 0 0 1 1 1 0 Lipoprotein amino terminal region adh_short PF00106.25 AET38848.1 - 2e-37 128.5 0.0 1.1e-35 122.8 0.0 2.4 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 AET38848.1 - 6.5e-22 78.2 0.0 4.6e-20 72.2 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AET38848.1 - 2.3e-08 34.2 0.0 0.00016 21.7 0.0 2.2 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 AET38848.1 - 0.0071 15.8 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 AET38848.1 - 0.0093 15.1 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Iwr1 PF08574.10 AET38849.1 - 1.6e-15 57.8 11.0 1.6e-15 57.8 11.0 3.4 3 0 0 3 3 3 1 Transcription factor Iwr1 Ribosomal_L6 PF00347.23 AET38850.1 - 5.6e-32 110.3 9.5 4.3e-18 65.8 3.9 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 SLS PF14611.6 AET38850.1 - 0.041 13.7 0.4 0.059 13.2 0.4 1.5 1 1 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator YbbR PF07949.12 AET38850.1 - 0.17 12.2 4.5 0.5 10.7 0.4 3.1 2 2 0 2 2 2 0 YbbR-like protein WSC PF01822.19 AET38851.1 - 3.2e-10 40.1 7.5 3.9e-10 39.8 7.5 1.1 1 0 0 1 1 1 1 WSC domain SUR7 PF06687.12 AET38851.1 - 0.057 13.0 1.0 0.069 12.8 1.0 1.2 1 0 0 1 1 1 0 SUR7/PalI family Nup84_Nup100 PF04121.13 AET38852.1 - 1.4e-182 608.6 7.8 1.7e-182 608.3 7.8 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 SH3_1 PF00018.28 AET38853.1 - 6.7e-08 32.0 0.0 2.1e-07 30.5 0.0 1.9 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AET38853.1 - 0.0079 16.0 0.1 0.017 15.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AET38853.1 - 0.018 14.7 0.0 0.037 13.7 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Transglut_core PF01841.19 AET38853.1 - 0.19 12.2 0.0 0.48 10.9 0.0 1.6 1 0 0 1 1 1 0 Transglutaminase-like superfamily Chorismate_synt PF01264.21 AET38854.1 - 9.1e-140 465.0 0.0 1e-139 464.8 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase RINT1_TIP1 PF04437.13 AET38855.1 - 5.1e-84 283.0 28.1 5.1e-84 283.0 28.1 2.2 2 1 0 2 2 2 1 RINT-1 / TIP-1 family baeRF_family6 PF18848.1 AET38855.1 - 0.02 15.3 0.1 0.085 13.3 0.0 2.1 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 6 SRP54_N PF02881.19 AET38855.1 - 0.14 12.4 2.1 1.1 9.5 0.5 3.5 3 0 0 3 3 3 0 SRP54-type protein, helical bundle domain Snapin_Pallidin PF14712.6 AET38855.1 - 0.42 11.1 8.5 0.2 12.1 0.6 3.0 1 1 1 2 2 2 0 Snapin/Pallidin DUF676 PF05057.14 AET38856.1 - 6.3e-57 192.6 0.0 1e-56 191.9 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.25 AET38856.1 - 0.00066 19.6 0.0 0.0014 18.5 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Palm_thioest PF02089.15 AET38856.1 - 0.0014 18.5 0.0 0.0024 17.8 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 AET38856.1 - 0.049 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.7 AET38856.1 - 0.063 13.0 0.0 0.16 11.7 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase family PCRF PF03462.18 AET38857.1 - 6.6e-52 176.2 0.1 5.1e-51 173.3 0.0 2.1 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 AET38857.1 - 3.7e-38 130.0 3.1 3.7e-38 130.0 3.1 1.8 2 0 0 2 2 2 1 RF-1 domain Pkinase PF00069.25 AET38858.1 - 8.5e-71 238.4 0.0 9.6e-71 238.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38858.1 - 4.8e-30 104.7 0.0 6.1e-30 104.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET38858.1 - 0.00032 20.1 0.0 0.00043 19.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AET38858.1 - 0.0076 16.2 0.1 0.019 14.9 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family DAO PF01266.24 AET38859.1 - 4.2e-55 187.7 0.0 4.7e-55 187.6 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 AET38859.1 - 1.7e-07 31.4 0.0 3.7e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 AET38859.1 - 4.5e-05 22.8 0.1 0.003 16.8 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AET38859.1 - 0.0013 18.1 0.6 0.0044 16.3 0.3 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AET38859.1 - 0.019 15.5 0.1 0.048 14.2 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 AET38859.1 - 0.082 13.2 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_9 PF13454.6 AET38859.1 - 0.13 12.2 0.1 0.34 10.9 0.1 1.7 1 0 0 1 1 1 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 AET38859.1 - 0.22 10.5 0.3 0.4 9.7 0.3 1.3 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 AET38859.1 - 0.23 10.1 0.1 0.56 8.8 0.1 1.6 2 0 0 2 2 2 0 HI0933-like protein Sel1 PF08238.12 AET38860.1 - 0.0039 17.8 2.9 3.9 8.3 0.0 4.2 5 0 0 5 5 5 2 Sel1 repeat TPR_8 PF13181.6 AET38860.1 - 0.63 10.4 8.2 14 6.2 0.1 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat Glyco_transf_22 PF03901.17 AET38861.1 - 9.7e-95 318.2 43.4 1.2e-94 317.9 43.4 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family HECT PF00632.25 AET38862.1 - 2.3e-81 273.6 0.4 4.5e-81 272.7 0.4 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 AET38863.1 - 6.4e-12 45.6 0.1 1.3e-11 44.7 0.1 1.5 1 0 0 1 1 1 1 SPRY domain Homeodomain PF00046.29 AET38865.1 - 6.8e-20 70.7 2.7 1.2e-19 69.9 2.7 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 AET38865.1 - 0.00091 19.1 1.4 0.0025 17.7 1.4 1.8 1 0 0 1 1 1 1 Homeobox KN domain L_protein_N PF15518.6 AET38865.1 - 0.14 12.0 0.2 0.14 12.0 0.2 1.9 2 0 0 2 2 2 0 L protein N-terminus Aldedh PF00171.22 AET38868.1 - 1.3e-161 538.3 0.0 1.4e-161 538.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 AET38868.1 - 0.017 14.6 0.0 0.17 11.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) LuxC PF05893.14 AET38868.1 - 0.024 13.7 0.0 0.047 12.7 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) Cep3 PF16846.5 AET38869.1 - 1.5e-204 680.3 23.1 1.8e-204 680.0 23.1 1.1 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit B Zn_clus PF00172.18 AET38869.1 - 1e-07 31.9 10.1 1.8e-07 31.1 10.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PUL PF08324.11 AET38869.1 - 0.068 12.4 0.2 0.21 10.8 0.2 1.8 1 1 0 1 1 1 0 PUL domain Mlh1_C PF16413.5 AET38870.1 - 3.9e-82 275.6 0.0 7.1e-82 274.8 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 AET38870.1 - 1.8e-31 108.3 1.3 2.7e-31 107.7 0.2 1.9 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 AET38870.1 - 2.1e-12 47.0 1.8 2.2e-12 47.0 0.1 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 AET38870.1 - 7.9e-07 29.6 0.1 3.2e-06 27.6 0.1 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GM_CSF PF01109.17 AET38870.1 - 0.067 13.3 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Granulocyte-macrophage colony-stimulating factor TIG PF01833.24 AET38871.1 - 6.9e-13 48.5 0.4 4.5e-10 39.5 0.1 2.8 2 0 0 2 2 2 2 IPT/TIG domain Ank_2 PF12796.7 AET38871.1 - 1e-11 45.2 0.1 4.5e-11 43.2 0.1 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 AET38871.1 - 2e-10 40.6 0.1 0.00017 21.9 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 AET38871.1 - 1.3e-09 37.4 0.1 0.00068 19.9 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 AET38871.1 - 4.4e-08 33.5 0.1 1.2e-07 32.2 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 AET38871.1 - 2e-07 31.1 0.0 5.6e-05 23.3 0.0 2.9 1 1 2 3 3 3 1 Ankyrin repeats (many copies) RHD_dimer PF16179.5 AET38871.1 - 0.017 15.1 0.0 0.041 13.9 0.0 1.6 1 0 0 1 1 1 0 Rel homology dimerisation domain PPTA PF01239.22 AET38872.1 - 2.8e-36 122.2 14.2 7e-08 32.0 0.2 5.4 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat DSPc PF00782.20 AET38873.1 - 4.5e-25 88.0 1.6 5.2e-24 84.5 1.6 2.1 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AET38873.1 - 0.0051 16.4 0.0 0.008 15.8 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Elf1 PF05129.13 AET38873.1 - 0.037 14.1 0.7 1.4 9.0 0.1 2.6 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like Yippee-Mis18 PF03226.14 AET38873.1 - 0.084 13.1 0.6 0.39 11.0 0.6 2.1 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PTPlike_phytase PF14566.6 AET38873.1 - 0.1 12.7 0.0 0.28 11.3 0.0 1.8 1 1 0 1 1 1 0 Inositol hexakisphosphate TerY_C PF15616.6 AET38873.1 - 0.17 12.0 1.7 1.8 8.7 0.1 2.4 2 1 0 2 2 2 0 TerY-C metal binding domain Apc15p PF05841.11 AET38874.1 - 4.9e-18 66.1 0.4 9.6e-18 65.2 0.4 1.5 1 0 0 1 1 1 1 Apc15p protein DUF1748 PF08520.10 AET38875.1 - 1.1e-22 79.7 0.1 1.7e-22 79.1 0.1 1.3 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) IRK_C PF17655.1 AET38875.1 - 0.061 12.9 0.0 0.067 12.8 0.0 1.1 1 0 0 1 1 1 0 Inward rectifier potassium channel C-terminal domain WD40 PF00400.32 AET38876.1 - 8.3e-12 45.4 1.2 0.002 18.9 0.0 5.3 4 1 1 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET38876.1 - 1.4e-06 28.5 0.0 0.032 14.5 0.0 4.1 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AET38876.1 - 3.4e-05 23.8 0.0 0.021 14.7 0.0 2.9 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 AET38876.1 - 0.047 12.2 0.0 2.2 6.7 0.0 2.7 2 2 0 2 2 2 0 Cytochrome D1 heme domain Nbas_N PF15492.6 AET38876.1 - 0.12 11.7 0.1 7.9 5.7 0.0 3.1 2 2 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal AAA_12 PF13087.6 AET38877.1 - 2.3e-58 197.1 0.1 5.4e-58 195.9 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 AET38877.1 - 7.6e-54 183.2 0.1 1.8e-53 182.0 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AET38877.1 - 6.8e-14 52.4 0.1 3.9e-12 46.7 0.0 3.5 3 1 0 3 3 3 1 AAA domain AAA_30 PF13604.6 AET38877.1 - 1e-10 41.7 0.0 6.3e-09 35.8 0.0 2.7 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 AET38877.1 - 6e-08 32.6 0.0 1.9e-07 31.0 0.0 1.9 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 AET38877.1 - 8.5e-07 28.9 0.2 0.45 10.2 0.0 3.4 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 AET38877.1 - 4.8e-06 26.2 0.0 0.00014 21.4 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein ResIII PF04851.15 AET38877.1 - 3.2e-05 24.0 0.0 0.00012 22.1 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AET38877.1 - 3.4e-05 23.7 0.4 0.00098 18.9 0.1 2.3 1 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AET38877.1 - 4.6e-05 23.7 0.1 0.00076 19.8 0.0 2.8 2 1 0 2 2 2 1 AAA domain Helicase_RecD PF05127.14 AET38877.1 - 0.00011 22.1 0.0 0.00089 19.2 0.0 2.5 2 0 0 2 2 2 1 Helicase IstB_IS21 PF01695.17 AET38877.1 - 0.0025 17.6 0.0 0.01 15.6 0.0 2.1 1 0 0 1 1 1 1 IstB-like ATP binding protein Rad17 PF03215.15 AET38877.1 - 0.0035 17.3 0.7 1.2 9.0 0.0 3.1 2 1 1 3 3 3 1 Rad17 P-loop domain UvrD_C_2 PF13538.6 AET38877.1 - 0.0056 16.5 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain PIF1 PF05970.14 AET38877.1 - 0.0086 15.3 0.0 0.25 10.4 0.0 2.4 2 0 0 2 2 2 1 PIF1-like helicase T2SSE PF00437.20 AET38877.1 - 0.012 14.8 0.0 0.024 13.7 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein TrwB_AAD_bind PF10412.9 AET38877.1 - 0.013 14.4 0.0 0.028 13.4 0.0 1.5 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_16 PF13191.6 AET38877.1 - 0.015 15.7 0.0 0.033 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 AET38877.1 - 0.017 15.5 0.0 0.088 13.2 0.0 2.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IL2 PF00715.17 AET38877.1 - 0.022 14.7 0.4 4.5 7.2 0.0 3.1 2 0 0 2 2 2 0 Interleukin 2 NB-ARC PF00931.22 AET38877.1 - 0.023 13.9 0.0 0.053 12.7 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain DUF2075 PF09848.9 AET38877.1 - 0.036 13.3 1.6 0.064 12.5 0.0 2.2 3 0 0 3 3 2 0 Uncharacterized conserved protein (DUF2075) AAA_24 PF13479.6 AET38877.1 - 0.037 13.8 1.9 0.1 12.3 0.2 2.4 2 1 0 2 2 2 0 AAA domain AAA_14 PF13173.6 AET38877.1 - 0.05 13.6 0.6 1.5 8.8 0.0 3.4 2 1 1 3 3 3 0 AAA domain DUF853 PF05872.12 AET38877.1 - 0.071 11.7 0.0 0.12 10.9 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Zot PF05707.12 AET38877.1 - 0.073 12.7 0.0 0.22 11.2 0.0 1.8 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) RsgA_GTPase PF03193.16 AET38877.1 - 0.074 13.0 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_25 PF13481.6 AET38877.1 - 0.086 12.4 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 AET38877.1 - 0.1 12.5 0.1 3.5 7.5 0.0 3.2 4 0 0 4 4 3 0 Adenylylsulphate kinase NACHT PF05729.12 AET38877.1 - 0.12 12.3 0.0 0.4 10.6 0.0 1.9 1 0 0 1 1 1 0 NACHT domain Flavi_DEAD PF07652.14 AET38877.1 - 0.18 11.7 0.0 0.47 10.4 0.0 1.7 1 0 0 1 1 1 0 Flavivirus DEAD domain UvrD_C PF13361.6 AET38877.1 - 0.68 9.2 5.8 1.8 7.9 5.7 2.0 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain Mt_ATP-synt_D PF05873.12 AET38878.1 - 2.7e-17 63.1 5.0 3.6e-17 62.7 5.0 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) DUF2408 PF10303.9 AET38878.1 - 0.026 15.1 3.6 0.068 13.7 3.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) LTXXQ PF07813.12 AET38878.1 - 0.12 13.1 2.3 1.9 9.3 0.7 2.1 2 0 0 2 2 2 0 LTXXQ motif family protein Tropomyosin_1 PF12718.7 AET38878.1 - 0.46 10.6 7.7 2.8 8.1 7.7 1.9 1 1 0 1 1 1 0 Tropomyosin like Fungal_trans PF04082.18 AET38879.1 - 9.3e-14 51.1 0.2 1.8e-13 50.2 0.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET38879.1 - 2.6e-10 40.2 7.0 5.4e-10 39.2 7.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BT1 PF03092.16 AET38879.1 - 0.0033 15.7 0.1 0.0051 15.1 0.1 1.2 1 0 0 1 1 1 1 BT1 family Spc24 PF08286.11 AET38879.1 - 0.4 10.9 4.1 9.1 6.6 0.2 2.5 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 CLZ PF16526.5 AET38879.1 - 2.2 8.7 6.9 4 7.9 0.7 2.6 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Npa1 PF11707.8 AET38880.1 - 2.3e-91 306.7 5.3 2.3e-91 306.7 5.3 2.5 2 0 0 2 2 2 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 AET38880.1 - 7.9e-55 185.6 0.2 3.4e-54 183.5 0.2 2.2 1 0 0 1 1 1 1 Nucleolar pre-ribosomal-associated protein 1 DUF5100 PF17029.5 AET38880.1 - 0.19 11.6 6.4 0.16 11.9 2.1 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF5100) DUF5321 PF17254.2 AET38881.1 - 3.7e-06 26.5 0.0 3.7e-06 26.5 0.0 2.0 2 1 0 2 2 2 1 Family of unknown function (DUF5321) Fungal_trans PF04082.18 AET38882.1 - 4.1e-22 78.5 2.1 4.1e-22 78.5 2.1 2.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET38882.1 - 0.0001 22.3 7.1 0.00021 21.3 7.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain YusW PF14039.6 AET38882.1 - 0.011 16.2 0.3 0.082 13.4 0.2 2.3 2 0 0 2 2 2 0 YusW-like protein Lar_restr_allev PF14354.6 AET38882.1 - 0.2 12.1 3.0 0.46 10.9 3.0 1.6 1 0 0 1 1 1 0 Restriction alleviation protein Lar ARPC4 PF05856.12 AET38883.1 - 7.2e-70 233.9 7.4 8.1e-70 233.8 7.4 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) FF PF01846.19 AET38884.1 - 1.1e-38 131.1 13.5 3.9e-14 52.5 0.0 5.8 5 0 0 5 5 5 4 FF domain WW PF00397.26 AET38884.1 - 2.1e-19 69.3 17.3 1.7e-12 47.2 1.2 3.2 3 0 0 3 3 3 2 WW domain Glyco_hyd_101C PF17451.2 AET38884.1 - 0.00063 20.0 6.3 0.032 14.5 0.5 3.0 1 1 1 2 2 2 2 Glycosyl hydrolase 101 beta sandwich domain Allexi_40kDa PF05549.11 AET38884.1 - 0.0056 16.2 3.8 0.013 15.0 0.1 2.3 2 0 0 2 2 2 1 Allexivirus 40kDa protein SATase_N PF06426.14 AET38884.1 - 0.033 14.6 0.2 0.25 11.7 0.1 2.4 1 1 1 2 2 2 0 Serine acetyltransferase, N-terminal Pox_polyA_pol_N PF12630.7 AET38884.1 - 5.3 7.4 7.1 3.4 8.1 0.3 3.3 3 1 0 3 3 3 0 Poxvirus poly(A) polymerase N-terminal domain Peptidase_S24 PF00717.23 AET38885.1 - 1.6e-08 34.3 0.1 2.8e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 Peptidase S24-like NAD_binding_10 PF13460.6 AET38886.1 - 8.5e-39 133.3 0.0 9.9e-39 133.1 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 AET38886.1 - 1.5e-09 37.7 0.0 9.9e-09 35.1 0.0 1.8 1 1 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 AET38886.1 - 6.1e-08 32.0 0.1 8.3e-08 31.6 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 AET38886.1 - 3.7e-05 24.1 0.0 6.5e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 AET38886.1 - 0.00012 22.4 0.0 0.00022 21.5 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 AET38886.1 - 0.0011 18.4 0.0 0.0022 17.5 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 AET38886.1 - 0.0021 17.5 0.0 0.0077 15.7 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 AET38886.1 - 0.0051 16.9 0.0 0.01 15.9 0.0 1.6 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Glycos_transf_1 PF00534.20 AET38886.1 - 0.14 11.7 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferases group 1 Ydc2-catalyt PF09159.10 AET38887.1 - 1.3e-43 149.8 0.1 3.8e-43 148.2 0.1 1.7 1 1 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Pox_A22 PF04848.13 AET38887.1 - 0.1 12.7 0.7 2.7 8.1 0.1 2.9 2 1 0 2 2 2 0 Poxvirus A22 protein zf-Tim10_DDP PF02953.15 AET38889.1 - 2e-20 72.2 3.2 2.5e-20 71.9 3.2 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Phage_DsbA PF11126.8 AET38889.1 - 0.031 14.5 0.2 0.085 13.1 0.1 1.7 1 1 1 2 2 2 0 Transcriptional regulator DsbA Tom5 PF10642.9 AET38889.1 - 0.19 11.8 1.0 0.33 11.0 1.0 1.3 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase Cyto_heme_lyase PF01265.17 AET38890.1 - 6.4e-44 150.7 1.6 3.5e-42 145.0 1.6 2.0 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase G-alpha PF00503.20 AET38891.1 - 2e-111 372.6 1.7 2.7e-111 372.2 1.7 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 AET38891.1 - 5.3e-15 55.3 1.4 4.4e-10 39.3 0.0 2.7 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AET38891.1 - 0.0016 17.9 2.4 0.024 14.0 0.1 2.3 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AET38891.1 - 0.029 14.4 0.0 2.4 8.3 0.0 2.9 4 0 0 4 4 4 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AET38891.1 - 0.042 13.4 0.0 0.62 9.6 0.0 2.4 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain FtsK_SpoIIIE PF01580.18 AET38891.1 - 0.097 12.0 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Roc PF08477.13 AET38891.1 - 0.1 12.9 1.8 4.9 7.4 0.0 3.0 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase ParBc PF02195.18 AET38892.1 - 1.2e-14 54.4 0.0 1.4e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 ParB-like nuclease domain NPIP PF06409.11 AET38892.1 - 0.13 11.3 0.0 0.17 10.9 0.0 1.1 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) Ldh_1_C PF02866.18 AET38893.1 - 7.7e-55 185.3 0.0 1.6e-54 184.3 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 AET38893.1 - 1.6e-43 148.2 0.0 2.2e-43 147.7 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 AET38893.1 - 4.2e-05 22.7 0.0 5.8e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.16 AET38893.1 - 0.001 18.6 0.0 0.15 11.6 0.0 2.3 1 1 1 2 2 2 2 Family 4 glycosyl hydrolase THF_DHG_CYH_C PF02882.19 AET38893.1 - 0.0071 15.7 1.0 0.28 10.5 0.3 2.9 2 1 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain zf-CHY PF05495.12 AET38894.1 - 5.5e-12 46.0 14.3 6.8e-12 45.7 13.6 1.5 1 1 0 1 1 1 1 CHY zinc finger Rad50_zn_hook PF04423.14 AET38894.1 - 1.8 8.5 8.6 4.5 7.2 2.7 2.6 2 0 0 2 2 2 0 Rad50 zinc hook motif Ank_2 PF12796.7 AET38895.1 - 3.7e-26 91.5 1.3 3.3e-09 37.2 0.0 3.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 AET38895.1 - 5.9e-19 68.2 3.4 1.1e-07 32.2 0.5 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 AET38895.1 - 1.1e-13 50.0 5.3 0.0097 16.4 0.0 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 AET38895.1 - 2.5e-13 49.8 9.8 0.00025 21.4 0.0 4.8 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 AET38895.1 - 8.1e-12 45.1 0.3 0.00029 21.0 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeats (many copies) TUG-UBL1 PF11470.8 AET38896.1 - 5.2e-18 65.0 0.2 1.6e-17 63.5 0.2 1.9 1 0 0 1 1 1 1 TUG ubiquitin-like domain UBX PF00789.20 AET38896.1 - 1.9e-11 44.0 0.1 6.3e-11 42.3 0.1 2.0 1 0 0 1 1 1 1 UBX domain PPR_3 PF13812.6 AET38897.1 - 0.00021 21.3 0.1 5.4 7.2 0.0 4.5 4 0 0 4 4 4 2 Pentatricopeptide repeat domain PPR_long PF17177.4 AET38897.1 - 0.027 13.8 0.1 0.11 11.8 0.0 2.1 2 0 0 2 2 2 0 Pentacotripeptide-repeat region of PRORP PPR_2 PF13041.6 AET38897.1 - 0.04 14.1 2.6 26 5.1 0.0 5.1 6 0 0 6 6 6 0 PPR repeat family SURF6 PF04935.12 AET38898.1 - 7.8e-47 159.6 49.9 7.8e-47 159.6 49.9 2.4 2 1 0 2 2 2 1 Surfeit locus protein 6 RRP14 PF15459.6 AET38898.1 - 9.3e-12 45.4 7.1 9.3e-12 45.4 7.1 7.2 5 2 1 6 6 6 1 60S ribosome biogenesis protein Rrp14 SlyX PF04102.12 AET38898.1 - 8.9 7.0 12.7 5.3 7.7 1.5 3.6 3 0 0 3 3 3 0 SlyX EF1G PF00647.19 AET38899.1 - 8.6e-45 151.2 0.1 1.5e-44 150.4 0.1 1.4 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 AET38899.1 - 9.5e-09 35.4 0.0 9.5e-09 35.4 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 AET38899.1 - 1.7e-08 34.7 0.1 4.6e-08 33.3 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 AET38899.1 - 0.00032 21.0 0.0 0.00082 19.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 AET38899.1 - 0.077 13.0 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain V-ATPase_C PF03223.15 AET38900.1 - 3.2e-118 395.4 4.5 3.6e-118 395.2 4.5 1.0 1 0 0 1 1 1 1 V-ATPase subunit C Kinesin PF00225.23 AET38901.1 - 1e-101 340.3 1.7 1.5e-101 339.7 1.7 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 AET38901.1 - 1.5e-24 86.6 0.0 3.6e-24 85.4 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding GOLGA2L5 PF15070.6 AET38901.1 - 0.00036 19.3 18.1 0.00053 18.8 18.1 1.1 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 Endonuclease_NS PF01223.23 AET38902.1 - 5.6e-64 216.0 0.0 6.7e-64 215.8 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Toxin_22 PF08092.11 AET38902.1 - 0.16 12.1 0.2 0.27 11.3 0.2 1.4 1 0 0 1 1 1 0 Magi peptide toxin family Tht1 PF04163.12 AET38903.1 - 1.1e-40 140.0 15.2 1.7e-38 132.7 15.2 2.2 1 1 0 1 1 1 1 Tht1-like nuclear fusion protein Apolipoprotein PF01442.18 AET38903.1 - 3.4e-05 23.8 0.1 0.0027 17.6 0.2 2.2 2 0 0 2 2 2 1 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.11 AET38903.1 - 0.00016 21.8 5.1 0.12 12.5 3.1 2.6 2 0 0 2 2 2 2 Apolipophorin-III precursor (apoLp-III) Spc7 PF08317.11 AET38903.1 - 0.0012 17.8 3.1 0.0025 16.7 2.4 1.8 2 0 0 2 2 2 1 Spc7 kinetochore protein Filament PF00038.21 AET38903.1 - 0.0013 18.4 3.3 0.0013 18.4 3.3 1.6 2 0 0 2 2 1 1 Intermediate filament protein DUF812 PF05667.11 AET38903.1 - 0.0014 17.6 1.7 0.0035 16.3 0.6 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF812) Phasin PF05597.11 AET38903.1 - 0.003 17.6 2.8 0.23 11.5 0.8 2.5 2 0 0 2 2 2 1 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF4618 PF15397.6 AET38903.1 - 0.0033 16.9 1.5 0.27 10.6 0.6 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4618) TMPIT PF07851.13 AET38903.1 - 0.0072 15.6 0.8 0.019 14.2 0.7 1.7 2 0 0 2 2 1 1 TMPIT-like protein BLOC1S3 PF15753.5 AET38903.1 - 0.0082 16.3 3.3 0.12 12.5 0.7 2.5 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex 1 subunit 3 Syntaxin-6_N PF09177.11 AET38903.1 - 0.01 16.4 3.5 0.053 14.1 1.4 2.6 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF1664 PF07889.12 AET38903.1 - 0.012 15.7 6.1 0.38 10.8 2.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Muted PF14942.6 AET38903.1 - 0.012 16.0 7.7 0.16 12.3 5.5 2.4 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein KxDL PF10241.9 AET38903.1 - 0.014 15.6 2.1 0.16 12.3 1.5 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein CLZ PF16526.5 AET38903.1 - 0.021 15.2 4.3 8.8 6.8 0.0 2.7 2 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DASH_Dam1 PF08653.10 AET38903.1 - 0.027 14.3 1.2 6.8 6.6 0.0 3.1 2 0 0 2 2 2 0 DASH complex subunit Dam1 Baculo_PEP_C PF04513.12 AET38903.1 - 0.029 14.4 11.6 0.16 12.0 1.5 3.5 2 1 2 4 4 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus s48_45 PF07422.13 AET38903.1 - 0.03 14.9 0.3 0.067 13.8 0.3 1.6 1 0 0 1 1 1 0 Sexual stage antigen s48/45 domain DUF1043 PF06295.12 AET38903.1 - 0.03 14.3 1.0 0.84 9.6 2.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) EspB PF05802.11 AET38903.1 - 0.031 14.3 1.0 0.11 12.4 0.0 2.1 2 0 0 2 2 2 0 Enterobacterial EspB protein AAA_32 PF13654.6 AET38903.1 - 0.033 13.0 2.2 0.056 12.2 2.2 1.3 1 0 0 1 1 1 0 AAA domain DGCR6 PF07324.11 AET38903.1 - 0.034 13.8 1.9 0.066 12.8 1.9 1.4 1 0 0 1 1 1 0 DiGeorge syndrome critical region 6 (DGCR6) protein PI3K_P85_iSH2 PF16454.5 AET38903.1 - 0.035 13.7 4.5 0.057 13.0 3.2 1.9 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF4795 PF16043.5 AET38903.1 - 0.046 13.3 8.5 0.11 12.1 4.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Laminin_II PF06009.12 AET38903.1 - 0.082 12.9 1.4 0.65 10.0 0.6 2.4 2 0 0 2 2 2 0 Laminin Domain II FapA PF03961.13 AET38903.1 - 0.086 11.4 1.9 0.093 11.3 0.9 1.5 2 0 0 2 2 2 0 Flagellar Assembly Protein A Glutaredoxin2_C PF04399.13 AET38903.1 - 0.097 12.5 1.6 17 5.2 0.5 3.0 3 1 0 3 3 2 0 Glutaredoxin 2, C terminal domain Prominin PF05478.11 AET38903.1 - 0.1 10.6 5.4 0.072 11.0 1.9 1.9 1 1 0 2 2 2 0 Prominin TPR_MLP1_2 PF07926.12 AET38903.1 - 0.11 12.5 5.6 0.24 11.4 4.0 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein FlaC_arch PF05377.11 AET38903.1 - 0.15 12.5 10.4 1.3 9.4 0.2 3.2 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF1104 PF06518.11 AET38903.1 - 0.18 12.2 4.4 0.36 11.2 4.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1104) Exonuc_VII_L PF02601.15 AET38903.1 - 0.27 10.7 1.3 0.47 10.0 1.2 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit Cep57_MT_bd PF06657.13 AET38903.1 - 0.3 11.6 6.4 0.63 10.5 2.5 2.8 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Matrilin_ccoil PF10393.9 AET38903.1 - 0.3 11.0 4.1 10 6.1 4.1 2.8 1 1 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF16 PF01519.16 AET38903.1 - 0.32 11.5 7.4 29 5.2 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function DUF16 HIP1_clath_bdg PF16515.5 AET38903.1 - 0.33 11.6 5.5 0.28 11.8 3.7 1.8 2 0 0 2 2 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF848 PF05852.11 AET38903.1 - 0.37 10.9 9.6 0.54 10.4 5.0 2.6 2 1 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Fib_alpha PF08702.10 AET38903.1 - 0.43 10.8 7.6 2.3 8.4 4.1 2.7 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Fzo_mitofusin PF04799.13 AET38903.1 - 0.44 10.1 3.1 3.1 7.3 1.8 2.6 3 0 0 3 3 3 0 fzo-like conserved region AIP3 PF03915.13 AET38903.1 - 0.46 9.5 9.2 11 5.0 9.2 2.1 1 1 0 1 1 1 0 Actin interacting protein 3 YtxH PF12732.7 AET38903.1 - 0.66 10.6 6.8 1.9 9.1 3.6 3.0 2 1 0 2 2 2 0 YtxH-like protein DASH_Duo1 PF08651.10 AET38903.1 - 0.84 9.5 5.5 18 5.2 0.8 3.5 2 1 1 3 3 3 0 DASH complex subunit Duo1 MIP-T3_C PF17749.1 AET38903.1 - 1.2 9.1 9.3 3.2 7.7 0.1 2.9 2 1 0 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region MCPsignal PF00015.21 AET38903.1 - 1.6 8.5 4.6 0.78 9.5 0.4 2.4 3 0 0 3 3 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF5082 PF16888.5 AET38903.1 - 2.3 8.5 10.2 41 4.5 7.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) SlyX PF04102.12 AET38903.1 - 5.4 7.7 6.0 13 6.5 0.3 3.1 3 1 0 3 3 2 0 SlyX TRPM_tetra PF16519.5 AET38903.1 - 6.7 6.9 12.5 23 5.2 4.5 3.5 3 2 0 3 3 2 0 Tetramerisation domain of TRPM XhlA PF10779.9 AET38903.1 - 8.8 6.6 11.1 58 4.0 6.2 3.1 2 1 1 3 3 3 0 Haemolysin XhlA SUR7 PF06687.12 AET38904.1 - 6.1e-30 104.4 17.4 8.3e-30 104.0 17.4 1.1 1 0 0 1 1 1 1 SUR7/PalI family CobD_Cbib PF03186.13 AET38904.1 - 0.041 13.1 0.7 0.061 12.5 0.7 1.2 1 0 0 1 1 1 0 CobD/Cbib protein HA2 PF04408.23 AET38905.1 - 1.3e-19 70.4 0.0 2.9e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 AET38905.1 - 2.9e-13 50.1 0.0 1.6e-12 47.7 0.0 2.2 3 0 0 3 3 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 AET38905.1 - 6.7e-12 45.6 0.0 1.7e-11 44.3 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 AET38905.1 - 2.5e-09 37.1 0.3 1e-08 35.2 0.1 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AET38905.1 - 3.8e-05 24.0 0.1 9.5e-05 22.7 0.1 1.6 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 AET38905.1 - 0.00086 19.0 0.1 0.0042 16.7 0.1 1.9 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_30 PF13604.6 AET38905.1 - 0.0019 17.9 0.0 0.0034 17.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AET38905.1 - 0.0037 17.6 0.1 0.0068 16.7 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 AET38905.1 - 0.0096 15.6 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AET38905.1 - 0.034 14.0 0.0 0.071 13.0 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 AET38905.1 - 0.038 14.5 0.3 0.13 12.7 0.3 1.9 1 1 0 1 1 1 0 ABC transporter AAA_25 PF13481.6 AET38905.1 - 0.11 12.0 0.0 0.42 10.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 AET38905.1 - 0.11 11.7 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_24 PF13479.6 AET38905.1 - 0.12 12.1 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 AET38905.1 - 0.17 11.4 0.1 0.54 9.7 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region Flavi_DEAD PF07652.14 AET38905.1 - 0.19 11.7 0.0 0.39 10.7 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain Sugar_tr PF00083.24 AET38906.1 - 6.5e-124 414.2 16.5 8.1e-124 413.9 16.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AET38906.1 - 1.2e-29 103.4 21.7 5e-23 81.6 3.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 AET38906.1 - 0.00017 20.1 0.5 0.00044 18.8 0.5 1.6 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OppC_N PF12911.7 AET38906.1 - 0.013 15.5 0.5 0.29 11.1 0.2 3.2 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C ArgJ PF01960.18 AET38907.1 - 8.4e-142 472.3 2.7 9.6e-142 472.1 2.7 1.0 1 0 0 1 1 1 1 ArgJ family ECD PF18432.1 AET38907.1 - 0.16 11.9 1.3 0.36 10.8 0.2 2.1 2 0 0 2 2 2 0 Extracellular Cadherin domain Suf PF05843.14 AET38908.1 - 1.3e-57 196.1 20.2 1.1e-52 179.9 7.2 4.3 4 1 1 5 5 5 2 Suppressor of forked protein (Suf) TPR_17 PF13431.6 AET38908.1 - 0.0029 17.9 0.6 0.17 12.3 0.0 4.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 AET38908.1 - 0.061 14.2 0.0 28 5.9 0.0 4.1 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF5332 PF17266.2 AET38908.1 - 0.083 12.6 2.3 8.6 6.0 0.1 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5332) Tom37_C PF11801.8 AET38909.1 - 1.8e-46 157.8 0.2 2.6e-46 157.2 0.2 1.3 1 0 0 1 1 1 1 Tom37 C-terminal domain Tom37 PF10568.9 AET38909.1 - 2.4e-28 99.0 0.9 6.2e-28 97.6 0.9 1.8 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 AET38909.1 - 0.0022 18.7 0.1 0.019 15.7 0.0 2.6 2 1 0 2 2 2 1 Glutathione S-transferase N-terminal domain Sen15 PF09631.10 AET38910.1 - 3.7e-26 91.3 0.0 5.1e-26 90.9 0.0 1.2 1 0 0 1 1 1 1 Sen15 protein DUF4448 PF14610.6 AET38911.1 - 5e-53 179.7 0.4 9.2e-53 178.8 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF5390 PF17365.2 AET38911.1 - 0.019 15.2 0.1 0.036 14.3 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5390) His_Phos_2 PF00328.22 AET38912.1 - 0.081 12.2 3.4 0.5 9.7 3.4 2.0 1 1 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) PRA-PH PF01503.17 AET38912.1 - 0.13 12.8 0.1 0.4 11.1 0.1 1.9 1 0 0 1 1 1 0 Phosphoribosyl-ATP pyrophosphohydrolase TryThrA_C PF12319.8 AET38912.1 - 0.2 11.1 4.0 0.34 10.3 4.0 1.3 1 0 0 1 1 1 0 Tryptophan-Threonine-rich plasmodium antigen C terminal Cu-oxidase_2 PF07731.14 AET38913.1 - 6.7e-49 165.2 7.5 2.4e-42 143.9 0.7 2.9 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 AET38913.1 - 5.3e-42 142.6 2.3 1.2e-38 131.7 0.2 3.6 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 AET38913.1 - 6e-33 114.2 7.2 3.4e-32 111.7 0.9 3.8 4 1 1 5 5 5 1 Multicopper oxidase C1q PF00386.21 AET38913.1 - 0.058 13.6 0.0 0.18 12.0 0.0 1.8 1 0 0 1 1 1 0 C1q domain RabGAP-TBC PF00566.18 AET38914.1 - 5.6e-36 124.2 0.0 7.5e-36 123.8 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain RRM_1 PF00076.22 AET38915.1 - 0.087 12.7 0.0 0.3 10.9 0.0 2.0 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2824 PF11039.8 AET38915.1 - 0.2 11.6 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2824) AA_permease PF00324.21 AET38916.1 - 1.2e-121 406.7 30.0 1.4e-121 406.5 30.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AET38916.1 - 1.2e-21 77.1 29.9 1.5e-21 76.8 29.5 1.3 1 1 0 1 1 1 1 Amino acid permease CtIP_N PF10482.9 AET38916.1 - 0.12 12.4 0.1 0.19 11.8 0.1 1.2 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain DUF1712 PF08217.11 AET38918.1 - 7.2e-173 576.3 9.4 9e-173 576.0 9.4 1.1 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) SRP54 PF00448.22 AET38919.1 - 4.2e-78 261.5 0.5 4.2e-78 261.5 0.5 2.2 3 0 0 3 3 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 AET38919.1 - 1.5e-29 102.5 8.1 1.5e-29 102.5 8.1 4.0 3 1 1 4 4 2 1 Signal peptide binding domain SRP54_N PF02881.19 AET38919.1 - 9.3e-13 48.2 5.5 2.9e-12 46.6 5.5 1.9 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 AET38919.1 - 5.2e-05 22.9 2.6 0.00041 20.0 0.8 2.9 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 AET38919.1 - 0.00012 22.2 0.0 0.00058 19.9 0.0 2.3 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_33 PF13671.6 AET38919.1 - 0.00024 21.3 0.0 0.00095 19.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 AET38919.1 - 0.0014 19.1 0.5 0.0058 17.0 0.1 2.3 2 0 0 2 2 2 1 AAA domain MobB PF03205.14 AET38919.1 - 0.0026 17.6 0.4 0.0069 16.3 0.0 2.0 2 0 0 2 2 1 1 Molybdopterin guanine dinucleotide synthesis protein B VirE PF05272.11 AET38919.1 - 0.0049 16.6 0.1 0.013 15.3 0.1 1.8 1 0 0 1 1 1 1 Virulence-associated protein E AAA_18 PF13238.6 AET38919.1 - 0.006 17.1 0.1 0.042 14.4 0.0 2.4 2 1 0 2 2 2 1 AAA domain APS_kinase PF01583.20 AET38919.1 - 0.016 15.1 0.0 0.038 13.9 0.0 1.7 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_30 PF13604.6 AET38919.1 - 0.019 14.7 0.0 0.05 13.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 AET38919.1 - 0.021 14.3 6.8 1.7 8.1 0.2 4.1 3 2 1 4 4 4 0 Signal recognition particle receptor beta subunit AAA_31 PF13614.6 AET38919.1 - 0.022 14.7 0.0 0.022 14.7 0.0 2.5 3 0 0 3 3 3 0 AAA domain ATP_bind_1 PF03029.17 AET38919.1 - 0.026 14.3 0.1 0.087 12.6 0.1 1.9 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 AET38919.1 - 0.031 14.7 0.0 0.059 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain MeaB PF03308.16 AET38919.1 - 0.034 13.1 0.0 0.034 13.1 0.0 2.3 3 1 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Arf PF00025.21 AET38919.1 - 0.036 13.5 0.1 0.78 9.2 0.0 2.9 2 1 1 3 3 3 0 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AET38919.1 - 0.036 14.2 1.0 0.15 12.2 0.1 2.5 3 1 0 3 3 2 0 50S ribosome-binding GTPase MipZ PF09140.11 AET38919.1 - 0.036 13.4 0.3 0.89 8.8 0.2 2.6 2 1 0 2 2 2 0 ATPase MipZ CLP1_P PF16575.5 AET38919.1 - 0.048 13.5 0.3 14 5.5 0.0 2.8 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_24 PF13479.6 AET38919.1 - 0.064 13.0 0.2 0.23 11.2 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 AET38919.1 - 0.11 12.8 0.3 0.46 10.8 0.3 2.3 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AET38919.1 - 0.16 11.5 0.2 1.1 8.8 0.1 2.3 2 0 0 2 2 2 0 AAA domain ArsA_ATPase PF02374.15 AET38919.1 - 0.52 9.4 13.3 0.34 10.1 0.2 3.9 4 0 0 4 4 4 0 Anion-transporting ATPase NTPase_1 PF03266.15 AET38919.1 - 0.83 9.5 6.8 2.7 7.9 2.2 3.2 2 1 0 2 2 2 0 NTPase G-alpha PF00503.20 AET38919.1 - 0.9 8.6 7.5 0.92 8.6 0.1 2.8 2 1 1 3 3 3 0 G-protein alpha subunit ResIII PF04851.15 AET38919.1 - 1.8 8.6 5.4 2 8.4 1.8 2.6 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit SHE3 PF17078.5 AET38920.1 - 5.9e-82 274.8 31.2 8e-82 274.4 31.2 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 TMF_DNA_bd PF12329.8 AET38920.1 - 0.00043 20.2 6.6 0.00043 20.2 6.6 3.3 1 1 1 3 3 3 1 TATA element modulatory factor 1 DNA binding Spc7 PF08317.11 AET38920.1 - 0.017 14.0 21.4 0.013 14.4 19.7 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF3450 PF11932.8 AET38920.1 - 0.039 13.3 18.6 0.017 14.4 7.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Synaptobrevin PF00957.21 AET38920.1 - 0.066 13.0 0.8 0.2 11.5 0.2 2.1 1 1 0 2 2 2 0 Synaptobrevin GAS PF13851.6 AET38920.1 - 0.12 11.7 23.1 0.23 10.8 22.4 1.7 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 AET38920.1 - 0.2 11.7 10.4 0.27 11.3 2.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 AET38920.1 - 0.32 11.0 21.7 0.78 9.8 14.9 2.6 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein ADIP PF11559.8 AET38920.1 - 0.76 9.9 22.9 0.041 14.0 8.9 2.7 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Jnk-SapK_ap_N PF09744.9 AET38920.1 - 0.84 9.9 21.7 1.5 9.0 10.6 2.6 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 bZIP_1 PF00170.21 AET38920.1 - 1.2 9.3 20.4 1.2 9.3 0.1 4.7 3 1 2 5 5 5 0 bZIP transcription factor APG6_N PF17675.1 AET38920.1 - 1.4 9.5 24.0 4.6 7.8 13.5 2.7 1 1 1 2 2 2 0 Apg6 coiled-coil region Csm1_N PF18504.1 AET38920.1 - 2.5 8.5 18.4 0.34 11.3 1.9 4.0 1 1 3 4 4 4 0 Csm1 N-terminal domain YkyA PF10368.9 AET38920.1 - 4 7.1 24.8 3.4 7.3 17.0 2.7 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein DHR10 PF18595.1 AET38920.1 - 4.1 7.5 19.1 0.82 9.7 5.1 3.1 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain FlaC_arch PF05377.11 AET38920.1 - 4.7 7.7 8.3 64 4.0 0.1 4.1 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) UPF0242 PF06785.11 AET38920.1 - 9.2 6.3 24.8 0.48 10.5 13.6 2.7 1 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus THOC7 PF05615.13 AET38920.1 - 10 6.4 16.7 8 6.7 4.0 2.6 1 1 1 2 2 2 0 Tho complex subunit 7 PH PF00169.29 AET38921.1 - 1.4e-13 51.3 6.0 4.3e-06 27.2 0.2 2.7 2 1 0 2 2 2 2 PH domain PH_11 PF15413.6 AET38921.1 - 6.9e-05 23.2 11.6 0.0011 19.4 0.2 4.2 2 2 0 3 3 3 1 Pleckstrin homology domain PH_6 PF15406.6 AET38921.1 - 0.00026 21.2 0.0 1.1 9.6 0.0 2.5 2 1 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 AET38921.1 - 0.093 13.0 0.5 0.49 10.7 0.0 2.3 2 1 0 2 2 2 0 Pleckstrin homology domain PH_3 PF14593.6 AET38921.1 - 0.49 10.5 4.6 2.7 8.1 0.3 2.6 2 1 0 2 2 2 0 PH domain Pox_A32 PF04665.12 AET38922.1 - 0.0072 15.8 0.0 0.014 14.9 0.0 1.4 1 0 0 1 1 1 1 Poxvirus A32 protein AAA_28 PF13521.6 AET38922.1 - 0.034 14.4 0.2 0.068 13.4 0.2 1.7 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 AET38922.1 - 0.12 12.5 0.2 2.1 8.5 0.2 2.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase Atg14 PF10186.9 AET38923.1 - 2.7e-14 53.0 4.6 1.7e-12 47.1 4.5 2.1 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 ATP-synt_ab PF00006.25 AET38924.1 - 1.8e-66 223.9 0.0 2.4e-66 223.4 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 AET38924.1 - 5.3e-15 55.7 1.0 1.1e-14 54.7 1.0 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF3533 PF12051.8 AET38924.1 - 0.054 12.4 0.0 0.086 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) RVT_1 PF00078.27 AET38925.1 - 0.0065 16.0 0.1 0.89 9.0 0.0 2.6 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5595 PF18077.1 AET38925.1 - 4.9 7.3 7.6 2.1 8.5 0.6 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF5595) Glyco_transf_20 PF00982.21 AET38927.1 - 1.9e-199 663.3 0.1 2.2e-199 663.1 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_trans_1_4 PF13692.6 AET38927.1 - 7.9e-05 23.1 0.0 0.00039 20.9 0.0 2.1 1 1 1 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 AET38927.1 - 0.0024 17.4 0.3 0.047 13.2 0.1 2.7 2 1 0 2 2 2 1 Glycosyl transferases group 1 PP2C PF00481.21 AET38928.1 - 3.5e-63 213.7 0.0 1.2e-62 211.9 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C Tau95 PF09734.9 AET38929.1 - 1.1e-30 107.2 0.7 2.9e-30 105.9 0.7 1.7 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 AET38929.1 - 4.3e-21 75.4 0.0 7.5e-21 74.6 0.0 1.4 1 0 0 1 1 1 1 Tau95 Triple barrel domain Ribosomal_L31 PF01197.18 AET38930.1 - 0.00011 22.3 0.0 0.0002 21.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L31 Me-amine-dh_H PF06433.11 AET38930.1 - 0.083 11.7 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Methylamine dehydrogenase heavy chain (MADH) DIM1 PF02966.16 AET38931.1 - 2.8e-67 224.5 0.7 3.2e-67 224.4 0.7 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 HGTP_anticodon PF03129.20 AET38932.1 - 1.3e-21 76.5 0.1 3.3e-21 75.2 0.1 1.8 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 AET38932.1 - 1.7e-08 34.7 0.2 9.2e-08 32.3 0.2 2.3 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) RRM_1 PF00076.22 AET38934.1 - 2.1e-07 30.6 0.1 8.9e-06 25.4 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pex14_N PF04695.13 AET38934.1 - 0.0091 16.7 1.8 0.02 15.6 0.4 2.0 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region RecX PF02631.16 AET38934.1 - 0.22 12.0 1.7 0.6 10.6 0.4 2.3 1 1 1 2 2 2 0 RecX family GTP_EFTU PF00009.27 AET38935.1 - 1e-54 185.1 0.0 1.4e-54 184.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 AET38935.1 - 1.8e-40 137.7 0.0 4.3e-40 136.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 AET38935.1 - 1.5e-14 54.1 3.3 1.8e-14 53.8 1.2 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AET38935.1 - 0.00053 20.0 0.1 0.012 15.7 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 AET38935.1 - 0.043 13.7 0.7 0.043 13.7 0.7 2.3 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Opy2 PF09463.10 AET38937.1 - 7e-10 39.1 21.2 1e-09 38.5 21.2 1.2 1 0 0 1 1 1 1 Opy2 protein CbtA PF09490.10 AET38937.1 - 0.026 14.3 0.4 5 6.8 0.0 2.3 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) Gly-zipper_Omp PF13488.6 AET38937.1 - 0.03 14.3 14.4 0.038 14.0 3.4 2.4 2 0 0 2 2 2 0 Glycine zipper Yip1 PF04893.17 AET38937.1 - 0.033 13.9 0.0 0.055 13.2 0.0 1.3 1 0 0 1 1 1 0 Yip1 domain Adeno_E3_CR2 PF02439.15 AET38937.1 - 0.041 13.7 0.1 0.088 12.6 0.1 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Trp_oprn_chp PF09534.10 AET38937.1 - 0.062 13.1 0.9 6.1 6.6 0.0 2.4 2 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Gly-zipper_YMGG PF13441.6 AET38937.1 - 0.2 11.4 15.0 0.67 9.7 2.2 2.4 2 0 0 2 2 2 0 YMGG-like Gly-zipper Bacteriocin_IIc PF10439.9 AET38937.1 - 0.25 11.5 8.0 0.87 9.7 0.8 2.3 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide Syndecan PF01034.20 AET38937.1 - 0.52 10.3 0.1 0.52 10.3 0.1 1.9 2 0 0 2 2 2 0 Syndecan domain Rick_17kDa_Anti PF05433.15 AET38937.1 - 7.3 6.6 19.1 0.49 10.3 2.5 2.7 3 0 0 3 3 3 0 Glycine zipper 2TM domain Transketolase_N PF00456.21 AET38938.1 - 6.4e-155 515.2 0.0 8.6e-155 514.7 0.0 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 AET38938.1 - 5.9e-46 156.4 0.0 1.1e-45 155.5 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 AET38938.1 - 1.9e-12 47.1 0.0 4.3e-12 46.0 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 AET38938.1 - 0.011 14.9 0.0 0.094 11.9 0.0 2.2 1 1 1 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase LMWPc PF01451.21 AET38939.1 - 6.7e-44 149.7 0.0 7.5e-44 149.6 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Not3 PF04065.15 AET38940.1 - 3.6e-65 219.6 31.9 5e-49 166.8 20.7 2.2 1 1 1 2 2 2 2 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 AET38940.1 - 5.8e-38 130.0 2.4 6.3e-38 129.8 0.4 2.2 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family Erythro_esteras PF05139.14 AET38940.1 - 0.21 11.4 2.1 0.19 11.5 0.5 1.7 1 1 1 2 2 2 0 Erythromycin esterase L31 PF09784.9 AET38940.1 - 0.3 11.5 6.6 6.8 7.2 6.4 2.8 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L31 CoA_transf_3 PF02515.17 AET38940.1 - 0.33 10.0 1.1 0.86 8.7 0.1 1.9 1 1 1 2 2 2 0 CoA-transferase family III Fib_alpha PF08702.10 AET38940.1 - 8.3 6.6 12.4 2.6 8.2 1.6 2.7 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF2203 PF09969.9 AET38940.1 - 9.4 7.0 9.8 4.8 7.9 1.6 2.5 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) NAD_binding_4 PF07993.12 AET38941.1 - 2.2e-70 236.8 0.0 3.1e-70 236.3 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 AET38941.1 - 2.1e-67 227.6 0.0 2.8e-67 227.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 AET38941.1 - 8.5e-15 54.9 0.0 2.5e-14 53.4 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 AET38941.1 - 2.7e-11 43.4 0.0 5.2e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 AET38941.1 - 9e-09 34.7 0.0 1.8e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family AMP-binding_C PF13193.6 AET38941.1 - 0.00014 22.7 0.0 0.00089 20.2 0.0 2.3 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain GDP_Man_Dehyd PF16363.5 AET38941.1 - 0.0069 15.8 0.1 0.011 15.1 0.1 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 AET38941.1 - 0.011 15.7 0.0 0.051 13.5 0.0 2.1 1 1 0 1 1 1 0 NAD(P)H-binding Condensation PF00668.20 AET38941.1 - 0.089 11.4 0.2 1.6 7.3 0.0 2.1 2 0 0 2 2 2 0 Condensation domain SNF2_N PF00176.23 AET38942.1 - 3.4e-55 187.2 0.5 3.1e-54 184.0 0.5 2.4 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AET38942.1 - 4.1e-14 52.9 0.0 1.1e-13 51.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET38942.1 - 3.8e-08 33.5 0.0 8.5e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 AET38942.1 - 1.4e-07 31.3 10.0 1.4e-07 31.3 10.0 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.29 AET38942.1 - 9.2e-06 25.5 0.0 1.8e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_2 PF13923.6 AET38942.1 - 0.0015 18.3 9.4 0.0015 18.3 9.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AET38942.1 - 0.0022 18.0 6.6 0.0064 16.5 6.6 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 AET38942.1 - 0.0039 17.0 8.0 0.0039 17.0 8.0 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 AET38942.1 - 0.0055 16.8 9.4 0.0055 16.8 9.4 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 AET38942.1 - 0.021 15.2 10.4 0.021 15.2 10.4 2.4 2 0 0 2 2 2 0 Ring finger domain MH2 PF03166.14 AET38942.1 - 0.054 13.7 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 MH2 domain Prok-RING_4 PF14447.6 AET38942.1 - 0.065 13.1 8.8 0.16 11.8 8.8 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Zn_Tnp_IS91 PF14319.6 AET38942.1 - 0.074 13.1 11.7 0.12 12.4 3.6 2.5 2 0 0 2 2 2 0 Transposase zinc-binding domain zf-rbx1 PF12678.7 AET38942.1 - 0.074 13.3 6.2 0.2 12.0 6.2 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain Shugoshin_C PF07557.11 AET38942.1 - 0.31 10.9 1.4 0.77 9.6 1.4 1.6 1 0 0 1 1 1 0 Shugoshin C terminus zf-ANAPC11 PF12861.7 AET38942.1 - 0.6 10.2 6.4 0.14 12.2 1.4 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 AET38942.1 - 0.63 9.9 6.0 1.9 8.4 6.0 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain SRF-TF PF00319.18 AET38942.1 - 3.4 7.2 5.2 26 4.4 0.0 2.6 2 0 0 2 2 2 0 SRF-type transcription factor (DNA-binding and dimerisation domain) Spt4 PF06093.13 AET38942.1 - 8.9 6.5 10.0 0.92 9.7 3.8 2.3 2 0 0 2 2 2 0 Spt4/RpoE2 zinc finger TPR_1 PF00515.28 AET38943.1 - 4.5e-48 159.2 19.3 3e-07 30.0 0.0 10.2 10 1 0 10 10 10 8 Tetratricopeptide repeat TPR_2 PF07719.17 AET38943.1 - 5.6e-42 138.5 22.6 0.00018 21.3 0.0 10.0 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_17 PF13431.6 AET38943.1 - 3.7e-29 99.0 23.3 0.00047 20.3 0.3 11.9 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_8 PF13181.6 AET38943.1 - 5.7e-27 91.6 14.3 0.15 12.4 0.0 10.1 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_11 PF13414.6 AET38943.1 - 4.7e-22 77.4 24.4 6e-05 22.6 0.0 9.6 5 3 5 10 10 10 5 TPR repeat TPR_16 PF13432.6 AET38943.1 - 1.5e-21 76.7 21.8 8.2e-05 23.2 5.0 6.8 4 3 4 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.6 AET38943.1 - 6.6e-20 70.1 24.6 0.005 17.5 0.0 10.1 4 3 6 10 10 10 7 Tetratricopeptide repeat TPR_7 PF13176.6 AET38943.1 - 8e-18 63.1 17.6 0.0019 18.1 0.2 9.1 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_12 PF13424.6 AET38943.1 - 3.9e-17 62.3 39.0 0.00043 20.5 0.2 8.2 4 3 3 7 7 7 7 Tetratricopeptide repeat TPR_9 PF13371.6 AET38943.1 - 1.1e-16 60.7 19.8 0.00021 21.3 0.0 6.4 3 1 3 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 AET38943.1 - 3e-15 56.5 32.1 0.0003 21.2 2.0 7.3 4 3 2 7 7 6 4 Tetratricopeptide repeat TPR_6 PF13174.6 AET38943.1 - 7.1e-13 48.3 26.3 0.98 10.2 0.0 10.1 10 0 0 10 10 9 5 Tetratricopeptide repeat ANAPC3 PF12895.7 AET38943.1 - 3.7e-11 43.1 10.7 0.00022 21.4 0.1 3.8 4 0 0 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 AET38943.1 - 3e-05 23.7 19.4 0.086 12.7 0.5 7.4 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_15 PF13429.6 AET38943.1 - 0.00079 18.7 36.9 0.0036 16.6 0.1 5.8 2 1 0 5 5 4 3 Tetratricopeptide repeat RPN7 PF10602.9 AET38943.1 - 0.088 12.5 3.7 13 5.4 0.2 4.1 4 1 0 4 4 4 0 26S proteasome subunit RPN7 DevR PF01905.16 AET38943.1 - 0.15 11.1 0.6 0.33 10.0 0.6 1.5 1 0 0 1 1 1 0 CRISPR-associated negative auto-regulator DevR/Csa2 EnY2 PF10163.9 AET38944.1 - 6.1e-26 90.6 1.4 7.1e-26 90.4 1.4 1.0 1 0 0 1 1 1 1 Transcription factor e(y)2 DUF2247 PF10004.9 AET38944.1 - 0.036 13.9 0.9 0.043 13.6 0.9 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2247) DUF3987 PF13148.6 AET38944.1 - 0.07 12.1 0.9 0.083 11.9 0.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) DEP PF00610.21 AET38944.1 - 0.084 12.9 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) NUDIX PF00293.28 AET38945.1 - 1.3e-16 60.8 0.0 2.7e-16 59.8 0.0 1.5 2 0 0 2 2 2 1 NUDIX domain Med1 PF10744.9 AET38946.1 - 4.3e-24 85.3 0.6 9.8e-24 84.2 0.3 1.5 1 1 1 2 2 2 1 Mediator of RNA polymerase II transcription subunit 1 Spermine_synth PF01564.17 AET38947.1 - 7.8e-68 227.6 0.0 1.1e-67 227.1 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 AET38947.1 - 1.2e-23 82.8 0.0 2e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 AET38947.1 - 0.035 14.8 0.0 0.072 13.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_30 PF05430.11 AET38947.1 - 0.066 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_12 PF08242.12 AET38947.1 - 0.1 13.4 0.0 0.19 12.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Hist_deacetyl PF00850.19 AET38948.1 - 7.7e-70 235.8 0.0 1e-69 235.4 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Glycos_transf_1 PF00534.20 AET38949.1 - 2e-10 40.5 0.0 3.4e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AET38949.1 - 2.6e-06 27.9 0.0 5e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 AET38949.1 - 0.00024 21.2 0.1 0.00049 20.1 0.0 1.5 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 AET38949.1 - 0.027 14.8 0.0 0.059 13.8 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 DUF2227 PF09988.9 AET38949.1 - 0.092 12.6 1.3 0.12 12.2 0.2 1.8 2 0 0 2 2 2 0 Uncharacterized metal-binding protein (DUF2227) EF-hand_1 PF00036.32 AET38950.1 - 5.9e-30 100.6 3.5 2e-08 33.2 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 AET38950.1 - 3.7e-26 91.4 0.2 1.4e-13 51.1 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AET38950.1 - 2.2e-25 86.4 2.7 5.5e-08 32.1 0.0 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 AET38950.1 - 2e-17 61.8 3.7 4.9e-07 29.0 0.0 4.2 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 AET38950.1 - 8e-16 57.6 4.6 2.8e-07 30.3 0.0 3.9 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 AET38950.1 - 1.6e-12 47.6 0.0 1.5e-08 34.8 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 AET38950.1 - 5.6e-06 26.6 0.1 0.0044 17.3 0.0 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 AET38950.1 - 1.5e-05 25.2 0.1 0.25 11.7 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain UPF0154 PF03672.13 AET38950.1 - 0.00031 20.7 0.0 0.3 11.1 0.0 3.1 4 0 0 4 4 4 1 Uncharacterised protein family (UPF0154) Dockerin_1 PF00404.18 AET38950.1 - 0.005 17.0 0.2 1.3 9.3 0.1 2.5 1 1 2 3 3 3 2 Dockerin type I domain EF-hand_4 PF12763.7 AET38950.1 - 0.0066 16.4 0.2 0.02 14.9 0.1 1.7 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand DUF3349 PF11829.8 AET38950.1 - 0.0067 17.2 0.5 4.8 8.0 0.0 2.7 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) Caleosin PF05042.13 AET38950.1 - 0.0075 16.2 0.0 1.9 8.4 0.0 2.7 1 1 2 3 3 3 1 Caleosin related protein TerB PF05099.13 AET38950.1 - 0.0075 16.2 0.1 0.15 12.0 0.0 2.2 2 1 0 2 2 2 1 Tellurite resistance protein TerB DUF853 PF05872.12 AET38950.1 - 0.015 13.9 0.2 0.043 12.4 0.2 1.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF853) SurA_N_3 PF13624.6 AET38950.1 - 0.049 13.4 0.4 1.2 8.9 0.1 2.0 1 1 1 2 2 2 0 SurA N-terminal domain RNA_pol_Rpb4 PF03874.16 AET38950.1 - 0.056 13.8 1.0 0.7 10.2 0.1 2.5 2 1 1 3 3 3 0 RNA polymerase Rpb4 Glycos_trans_3N PF02885.17 AET38950.1 - 0.087 12.7 3.8 3.2 7.7 0.1 3.4 1 1 1 3 3 3 0 Glycosyl transferase family, helical bundle domain GPHH PF16905.5 AET38950.1 - 0.088 12.6 0.0 0.98 9.2 0.0 2.3 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated AIM3 PF17096.5 AET38951.1 - 7e-26 91.0 3.4 7e-26 91.0 3.4 6.2 6 1 0 6 6 6 2 Altered inheritance of mitochondria protein 3 Dscam_C PF12355.8 AET38951.1 - 0.11 13.4 0.3 0.11 13.4 0.3 6.1 3 1 2 6 6 6 0 Down syndrome cell adhesion molecule C terminal P3A PF08727.11 AET38951.1 - 0.13 11.7 1.4 1.2 8.6 0.3 2.9 2 0 0 2 2 2 0 Poliovirus 3A protein like Fe-S_biosyn PF01521.20 AET38953.1 - 1.2e-14 54.4 0.1 4e-13 49.5 0.1 2.2 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis ThiF PF00899.21 AET38954.1 - 5.8e-55 186.3 0.0 7.2e-55 186.0 0.0 1.1 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 AET38954.1 - 0.012 15.6 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 AET38954.1 - 0.08 13.5 0.1 0.13 12.8 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PAZ PF02170.22 AET38954.1 - 0.22 11.4 0.0 0.33 10.7 0.0 1.2 1 0 0 1 1 1 0 PAZ domain Pho88 PF10032.9 AET38955.1 - 8.7e-76 253.2 2.7 9.8e-76 253.1 2.7 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) DUF3278 PF11683.8 AET38955.1 - 0.92 9.6 5.2 0.63 10.1 2.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3278) HMG_box PF00505.19 AET38956.1 - 1.4e-13 51.0 5.4 7.1e-13 48.8 5.4 2.3 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 AET38956.1 - 3.5e-08 33.9 1.2 3.5e-08 33.9 1.2 3.1 3 0 0 3 3 3 1 HMG-box domain LMBR1 PF04791.16 AET38956.1 - 3.9 6.3 7.1 4.8 6.0 7.1 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Vac_ImportDeg PF09783.9 AET38957.1 - 1.1e-59 200.8 1.1 1.5e-59 200.4 1.1 1.1 1 0 0 1 1 1 1 Vacuolar import and degradation protein UPF0139 PF03669.13 AET38958.1 - 7.9e-05 22.5 1.8 0.00016 21.5 1.8 1.5 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0139) DUF1345 PF07077.11 AET38958.1 - 0.049 13.3 0.1 0.059 13.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1345) DUF5331 PF17265.2 AET38958.1 - 0.14 11.9 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5331) DnaJ PF00226.31 AET38959.1 - 1.9e-14 53.5 0.6 1.9e-07 31.1 0.0 2.3 2 0 0 2 2 2 2 DnaJ domain CM_2 PF01817.21 AET38960.1 - 0.037 14.4 0.0 0.52 10.7 0.1 2.3 2 0 0 2 2 2 0 Chorismate mutase type II SIP1 PF04938.12 AET38961.1 - 3.7e-09 36.6 1.2 1.3e-08 34.8 1.2 1.9 1 1 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) zf-C2H2 PF00096.26 AET38962.1 - 0.035 14.5 0.1 0.035 14.5 0.1 2.3 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AET38962.1 - 0.2 12.6 0.1 0.2 12.6 0.1 2.5 2 1 0 2 2 2 0 C2H2-type zinc finger Tfb4 PF03850.14 AET38963.1 - 1.6e-105 352.5 0.3 1.9e-105 352.3 0.3 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 Rad50_zn_hook PF04423.14 AET38963.1 - 0.14 12.0 0.4 0.14 12.0 0.4 2.3 2 0 0 2 2 2 0 Rad50 zinc hook motif WD40 PF00400.32 AET38964.1 - 1.1e-22 79.8 11.8 9.6e-05 23.1 0.0 7.7 7 1 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET38964.1 - 1.3e-13 51.1 2.8 7.3e-07 29.4 0.1 5.1 4 3 3 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 AET38964.1 - 9.3e-09 34.9 0.2 1.8e-08 34.1 0.2 1.5 1 0 0 1 1 1 1 LisH WD40_like PF17005.5 AET38964.1 - 6.8e-06 25.6 0.3 0.0025 17.2 0.2 2.5 2 1 0 2 2 2 2 WD40-like domain eIF2A PF08662.11 AET38964.1 - 0.00036 20.5 1.9 0.0038 17.1 0.2 3.2 4 1 0 4 4 4 1 Eukaryotic translation initiation factor eIF2A Exo84_C PF16528.5 AET38965.1 - 9e-64 215.1 13.7 1.4e-63 214.4 6.2 2.5 2 0 0 2 2 2 2 Exocyst component 84 C-terminal Vps51 PF08700.11 AET38965.1 - 1.1e-10 41.4 0.9 1.1e-10 41.4 0.9 2.2 2 0 0 2 2 2 1 Vps51/Vps67 COG2 PF06148.11 AET38965.1 - 0.025 14.7 0.2 0.025 14.7 0.2 3.0 3 1 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 APG6_N PF17675.1 AET38965.1 - 0.048 14.2 9.0 0.91 10.0 2.8 2.9 2 0 0 2 2 2 0 Apg6 coiled-coil region CusF_Ec PF11604.8 AET38965.1 - 0.15 12.1 0.0 19 5.3 0.0 2.5 2 0 0 2 2 2 0 Copper binding periplasmic protein CusF NUDE_C PF04880.13 AET38965.1 - 0.75 10.2 10.2 0.16 12.5 3.3 2.5 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region UFD1 PF03152.14 AET38966.1 - 6.7e-08 32.2 0.0 4.5e-05 23.0 0.0 2.9 2 1 0 2 2 2 1 Ubiquitin fusion degradation protein UFD1 AZUL PF16558.5 AET38966.1 - 1.6e-05 25.0 0.0 1.6e-05 25.0 0.0 2.7 3 0 0 3 3 3 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A zf_UBZ PF18439.1 AET38966.1 - 0.0099 15.5 10.3 0.57 9.8 0.1 4.8 4 0 0 4 4 4 1 Ubiquitin-Binding Zinc Finger zf-C2H2 PF00096.26 AET38966.1 - 0.044 14.3 0.2 0.044 14.3 0.2 6.7 7 1 0 7 7 7 0 Zinc finger, C2H2 type Sgf11 PF08209.11 AET38966.1 - 0.58 9.8 0.0 0.58 9.8 0.0 2.9 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) Fes1 PF08609.10 AET38967.1 - 6.5e-24 84.6 0.7 2.5e-23 82.7 0.7 2.1 1 0 0 1 1 1 1 Nucleotide exchange factor Fes1 DUF4704 PF15787.5 AET38967.1 - 0.0029 16.9 2.5 0.0082 15.4 2.5 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4704) HEAT_2 PF13646.6 AET38967.1 - 0.0087 16.4 0.0 0.89 10.0 0.0 2.7 2 1 0 2 2 2 1 HEAT repeats Atx10homo_assoc PF09759.9 AET38967.1 - 0.15 12.1 1.1 1.2 9.2 0.1 2.7 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain ERCC4 PF02732.15 AET38968.1 - 2.8e-10 40.6 2.2 2.8e-10 40.6 2.2 2.3 2 1 0 2 2 2 1 ERCC4 domain Sec8_exocyst PF04048.14 AET38969.1 - 5e-47 159.4 0.6 5e-47 159.4 0.6 2.4 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain DUF2451 PF10474.9 AET38969.1 - 1.6e-06 28.1 4.5 9.3e-06 25.6 1.8 3.0 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) Vps54_N PF10475.9 AET38969.1 - 0.00011 21.7 0.1 0.00011 21.7 0.1 2.5 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex DUF1192 PF06698.11 AET38969.1 - 0.1 12.7 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Pkinase PF00069.25 AET38970.1 - 1.7e-22 80.0 0.0 3.3e-22 79.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 AET38970.1 - 1.4e-10 40.4 7.9 0.0026 17.8 0.4 5.6 6 0 0 6 6 6 3 HEAT repeat Pkinase_Tyr PF07714.17 AET38970.1 - 2.4e-09 36.8 0.0 5.8e-09 35.6 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase HEAT_2 PF13646.6 AET38970.1 - 4.5e-07 30.2 0.0 0.074 13.5 0.0 3.3 2 1 1 3 3 3 2 HEAT repeats Cnd1 PF12717.7 AET38970.1 - 0.00014 21.9 3.2 0.13 12.3 0.7 4.0 2 2 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Kinase-like PF14531.6 AET38970.1 - 0.0023 17.3 0.0 0.0095 15.3 0.0 1.9 1 1 1 2 2 2 1 Kinase-like M11L PF11099.8 AET38970.1 - 0.0072 16.6 5.3 0.22 11.8 1.0 3.0 2 0 0 2 2 2 1 Apoptosis regulator M11L like WD40 PF00400.32 AET38970.1 - 0.014 16.3 5.7 6.9 7.7 0.1 4.9 4 0 0 4 4 4 0 WD domain, G-beta repeat HEAT_EZ PF13513.6 AET38970.1 - 0.023 15.2 0.3 1.2 9.8 0.1 3.5 3 0 0 3 3 3 0 HEAT-like repeat APH PF01636.23 AET38970.1 - 0.15 12.0 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 AET38971.1 - 1.5e-62 211.4 0.0 1.9e-62 211.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET38971.1 - 1.6e-29 103.0 0.0 2.2e-29 102.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AET38971.1 - 0.0023 16.9 0.2 0.0036 16.3 0.2 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 AET38971.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like RXT2_N PF08595.11 AET38972.1 - 1.4e-36 125.9 1.2 2.6e-36 125.0 0.0 2.0 2 0 0 2 2 2 1 RXT2-like, N-terminal zf-Tim10_DDP PF02953.15 AET38973.1 - 4e-15 55.2 0.2 5.9e-15 54.7 0.2 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger LCCL PF03815.19 AET38974.1 - 2.3e-08 34.0 0.1 4e-08 33.2 0.1 1.4 1 0 0 1 1 1 1 LCCL domain Sec6 PF06046.13 AET38975.1 - 1.2e-168 562.1 19.1 2.1e-168 561.3 19.1 1.4 1 0 0 1 1 1 1 Exocyst complex component Sec6 FadR_C PF07840.12 AET38975.1 - 0.0031 17.4 0.4 0.46 10.4 0.0 3.1 2 0 0 2 2 2 1 FadR C-terminal domain Baculo_PEP_C PF04513.12 AET38975.1 - 0.2 11.7 5.0 6.7 6.8 0.6 3.9 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus MitMem_reg PF13012.6 AET38975.1 - 0.48 10.9 10.6 51 4.3 4.6 4.8 4 2 0 4 4 4 0 Maintenance of mitochondrial structure and function Tctex-1 PF03645.13 AET38976.1 - 6.1e-08 32.8 0.0 1.5e-07 31.6 0.0 1.6 1 1 0 1 1 1 1 Tctex-1 family DUF202 PF02656.15 AET38977.1 - 4.6e-14 52.6 4.5 4.6e-14 52.6 4.5 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Herpes_UL43 PF05072.13 AET38977.1 - 0.018 14.1 0.2 0.022 13.8 0.2 1.1 1 0 0 1 1 1 0 Herpesvirus UL43 protein DUF5337 PF17272.2 AET38977.1 - 0.4 10.5 6.2 1.4 8.8 6.2 2.0 1 1 0 1 1 1 0 Family of unknown function (DUF5337) Ribosomal_S24e PF01282.19 AET38978.1 - 2.6e-36 123.4 0.1 4.1e-36 122.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e Yos1 PF08571.10 AET38979.1 - 1.5e-33 114.9 2.0 1.7e-33 114.7 2.0 1.0 1 0 0 1 1 1 1 Yos1-like Y_phosphatase PF00102.27 AET38980.1 - 1.7e-52 178.3 0.1 3e-52 177.6 0.1 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 AET38980.1 - 3.1e-09 37.3 0.0 2.1e-08 34.6 0.0 2.4 2 0 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.20 AET38980.1 - 0.00051 19.9 0.0 0.0017 18.1 0.0 1.9 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 AET38980.1 - 0.043 13.8 0.6 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 Tyrosine phosphatase family DUF2205 PF10224.9 AET38981.1 - 0.00057 19.8 1.4 0.00069 19.6 0.7 1.5 1 1 0 1 1 1 1 Short coiled-coil protein Rootletin PF15035.6 AET38981.1 - 0.017 15.2 1.3 0.02 14.9 1.3 1.0 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Actin PF00022.19 AET38983.1 - 2.4e-23 82.4 0.1 1.2e-10 40.6 0.0 2.3 1 1 1 2 2 2 2 Actin Serinc PF03348.15 AET38984.1 - 3.6e-138 461.1 20.3 4.2e-138 460.9 20.3 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) Rad51 PF08423.11 AET38985.1 - 4e-113 376.9 0.3 5.4e-113 376.5 0.0 1.3 2 0 0 2 2 2 1 Rad51 RecA PF00154.21 AET38985.1 - 1.1e-10 41.4 0.0 1.6e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 AET38985.1 - 5.3e-07 29.4 0.0 7.7e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 AET38985.1 - 2.4e-06 27.1 0.6 2e-05 24.1 0.3 2.4 2 1 0 2 2 2 1 KaiC HHH_5 PF14520.6 AET38985.1 - 9.3e-05 23.0 0.3 0.00032 21.2 0.1 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain PAXNEB PF05625.11 AET38985.1 - 0.069 12.3 0.1 0.21 10.7 0.1 1.6 2 0 0 2 2 2 0 PAXNEB protein RNA_pol_A_CTD PF03118.15 AET38985.1 - 0.12 12.2 0.2 0.3 10.9 0.2 1.6 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain Peptidase_M24 PF00557.24 AET38986.1 - 7.3e-06 25.8 0.0 1.4e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 Metallopeptidase family M24 E1_dh PF00676.20 AET38987.1 - 4.2e-122 406.8 0.3 5.1e-122 406.5 0.3 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 AET38987.1 - 0.0085 15.3 0.0 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase KRTAP7 PF15034.6 AET38987.1 - 0.23 12.4 7.3 0.33 12.0 0.2 3.4 2 2 1 3 3 3 0 KRTAP type 7 family Ste5_C PF12194.8 AET38988.1 - 7.7e-76 254.3 0.2 1.3e-75 253.5 0.2 1.4 1 0 0 1 1 1 1 Protein kinase Fus3-binding zf-RING_2 PF13639.6 AET38988.1 - 0.03 14.7 7.1 0.085 13.2 7.0 1.9 1 0 0 1 1 1 0 Ring finger domain Zn_ribbon_17 PF17120.5 AET38988.1 - 0.042 13.5 3.4 0.096 12.3 3.4 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 AET38988.1 - 0.18 11.8 3.7 0.45 10.6 3.7 1.7 1 0 0 1 1 1 0 RING-type zinc-finger PH_4 PF15404.6 AET38989.1 - 1.5e-71 240.0 0.0 3e-71 239.0 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Spo7_2_N PF15407.6 AET38989.1 - 9.6e-23 79.6 0.2 2.9e-22 78.1 0.2 1.9 1 0 0 1 1 1 1 Sporulation protein family 7 PH_12 PF16457.5 AET38989.1 - 0.0024 18.4 1.5 0.0078 16.8 1.4 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 AET38989.1 - 0.0078 16.7 4.6 2.6 8.6 0.0 4.0 5 0 0 5 5 5 2 PH domain PH_13 PF16652.5 AET38989.1 - 0.045 13.6 1.9 3.7 7.3 1.5 2.7 2 0 0 2 2 2 0 Pleckstrin homology domain COPI_assoc PF08507.10 AET38990.1 - 1.2e-28 99.7 8.1 1.5e-28 99.5 8.1 1.0 1 0 0 1 1 1 1 COPI associated protein Reticulon PF02453.17 AET38990.1 - 0.056 13.4 6.6 0.83 9.6 1.2 2.1 2 0 0 2 2 2 0 Reticulon 14-3-3 PF00244.20 AET38991.1 - 2.2e-106 354.4 4.5 2.5e-106 354.2 4.5 1.0 1 0 0 1 1 1 1 14-3-3 protein FlaF PF07309.11 AET38991.1 - 0.0032 17.5 0.1 0.0079 16.2 0.1 1.6 1 0 0 1 1 1 1 Flagellar protein FlaF SF3A2 PF16835.5 AET38991.1 - 0.11 12.9 0.1 0.26 11.7 0.1 1.6 1 0 0 1 1 1 0 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) Glutaredoxin PF00462.24 AET38992.1 - 2.7e-17 62.7 0.0 4.5e-16 58.8 0.0 2.4 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 AET38992.1 - 5.7e-12 45.5 0.0 1.1e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 AET38992.1 - 4.7e-05 23.6 0.6 0.00034 20.9 0.0 2.4 2 1 1 3 3 3 1 Thioredoxin-like AhpC-TSA PF00578.21 AET38992.1 - 0.0013 18.7 0.0 0.0024 17.8 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 AET38992.1 - 0.0092 16.4 0.0 0.088 13.3 0.1 2.4 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 AET38992.1 - 0.092 12.9 0.0 0.26 11.5 0.0 1.7 2 0 0 2 2 2 0 Thioredoxin-like DIM1 PF02966.16 AET38992.1 - 0.2 11.5 0.0 0.32 10.8 0.0 1.3 1 0 0 1 1 1 0 Mitosis protein DIM1 Rad17 PF03215.15 AET38993.1 - 2.2e-40 138.6 0.0 4.7e-39 134.2 0.0 2.3 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 AET38993.1 - 0.00034 21.1 0.0 0.0007 20.0 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 AET38993.1 - 0.042 14.4 0.0 0.15 12.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 AET38993.1 - 0.044 14.2 0.0 0.15 12.5 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Rsa3 PF14615.6 AET38993.1 - 0.051 13.1 0.0 0.27 10.8 0.0 2.3 3 0 0 3 3 3 0 Ribosome-assembly protein 3 AAA_22 PF13401.6 AET38993.1 - 0.058 13.7 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sec63 PF02889.16 AET38994.1 - 1.8e-141 469.7 8.8 5.6e-78 261.6 0.4 2.4 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 AET38994.1 - 1.1e-43 149.1 0.0 9.4e-27 93.9 0.1 2.7 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 AET38994.1 - 1.6e-25 90.1 0.1 3.1e-16 59.8 0.0 2.8 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_PWI PF18149.1 AET38994.1 - 1.5e-18 67.0 0.7 6.6e-18 64.9 0.7 2.2 1 0 0 1 1 1 1 N-terminal helicase PWI domain Helicase_C PF00271.31 AET38994.1 - 1.5e-10 41.4 0.0 1e-08 35.5 0.0 4.0 3 1 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 AET38994.1 - 3.4e-09 37.1 0.3 0.00095 19.4 0.0 3.7 3 1 0 3 3 3 2 AAA domain AAA PF00004.29 AET38994.1 - 0.011 16.1 0.5 1.8 9.0 0.0 3.6 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) TDH PF03347.13 AET38994.1 - 0.04 13.5 0.0 0.099 12.2 0.0 1.6 1 0 0 1 1 1 0 Vibrio thermostable direct hemolysin IstB_IS21 PF01695.17 AET38994.1 - 0.3 10.8 3.0 5.8 6.6 0.0 4.0 6 0 0 6 6 6 0 IstB-like ATP binding protein DEAD_2 PF06733.15 AET38995.1 - 6.3e-55 185.5 6.7 6.3e-55 185.5 6.7 2.3 3 0 0 3 3 3 1 DEAD_2 Helicase_C_2 PF13307.6 AET38995.1 - 7.3e-44 150.0 0.0 2.2e-43 148.4 0.0 1.9 1 0 0 1 1 1 1 Helicase C-terminal domain HBB PF06777.11 AET38995.1 - 1.8e-41 141.9 1.6 5.3e-37 127.3 0.3 2.7 2 0 0 2 2 2 2 Helical and beta-bridge domain ResIII PF04851.15 AET38995.1 - 0.0001 22.4 0.1 0.0028 17.7 0.1 2.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit YtxC PF08812.11 AET38995.1 - 0.026 14.1 3.4 0.18 11.4 0.1 3.1 3 1 0 3 3 3 0 YtxC-like family PhoH PF02562.16 AET38995.1 - 0.16 11.4 0.0 7.8 5.9 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein ADK PF00406.22 AET38996.1 - 2.2e-41 141.4 0.0 2.7e-41 141.2 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 AET38996.1 - 9.2e-19 68.2 0.0 1.5e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 AET38996.1 - 2e-13 50.1 0.0 4e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 AET38996.1 - 1.1e-05 26.0 0.0 2.5e-05 24.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AET38996.1 - 0.12 12.6 0.3 1.3 9.1 0.1 2.3 2 1 0 2 2 2 0 AAA domain MutS_V PF00488.21 AET38997.1 - 3.1e-66 223.0 0.3 7e-66 221.8 0.3 1.6 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 AET38997.1 - 1.3e-33 115.5 0.0 5.1e-33 113.7 0.0 2.0 2 0 0 2 2 2 1 MutS domain I MutS_III PF05192.18 AET38997.1 - 6.9e-32 111.2 0.1 1.6e-31 110.0 0.1 1.7 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 AET38997.1 - 3.7e-15 56.0 0.5 8.2e-15 54.9 0.5 1.6 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 AET38997.1 - 3.1e-11 43.7 0.0 9.8e-11 42.1 0.0 1.8 1 0 0 1 1 1 1 MutS domain II AAA_27 PF13514.6 AET38997.1 - 0.033 13.8 0.0 0.072 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 AET38997.1 - 0.072 12.8 0.0 0.23 11.2 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 AET38997.1 - 0.72 10.3 0.0 0.72 10.3 0.0 2.7 3 0 0 3 3 3 0 AAA domain JmjC PF02373.22 AET38998.1 - 6.4e-41 139.4 1.5 1.5e-40 138.2 1.5 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.17 AET38998.1 - 2.5e-16 59.3 1.5 9.7e-16 57.4 1.5 2.1 1 0 0 1 1 1 1 jmjN domain zf-H2C2_2 PF13465.6 AET38998.1 - 1.3e-06 28.6 7.2 1.3e-06 28.6 7.2 2.0 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 AET38998.1 - 3.5e-05 24.0 14.9 0.0088 16.5 2.6 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AET38998.1 - 6.4e-05 23.5 14.5 0.04 14.8 4.5 3.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 AET38998.1 - 0.0014 18.5 4.8 0.0014 18.5 4.8 2.9 3 0 0 3 3 3 1 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 AET38998.1 - 0.0022 18.1 3.5 0.0053 16.9 3.5 1.7 1 0 0 1 1 1 1 Zinc ribbon domain DZR PF12773.7 AET38998.1 - 0.051 13.6 1.2 0.12 12.4 1.2 1.6 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_5 PF13719.6 AET38998.1 - 0.27 11.0 1.4 0.69 9.7 1.4 1.7 1 0 0 1 1 1 0 zinc-ribbon domain zf_UBZ PF18439.1 AET38998.1 - 0.38 10.4 3.8 10 5.8 0.3 2.6 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-met PF12874.7 AET38998.1 - 4 8.0 8.2 12 6.5 0.8 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-BED PF02892.15 AET38998.1 - 4.3 7.5 6.7 19 5.4 1.6 2.8 2 0 0 2 2 2 0 BED zinc finger zf-C2H2_jaz PF12171.8 AET38998.1 - 4.3 7.7 16.8 0.094 13.0 4.3 2.9 2 1 1 3 3 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 AET38998.1 - 4.7 7.1 9.2 1 9.2 3.6 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type ANTH PF07651.16 AET38999.1 - 7.9e-59 198.9 0.1 7.9e-59 198.9 0.1 1.7 2 0 0 2 2 2 1 ANTH domain ENTH PF01417.20 AET38999.1 - 2.9e-06 27.3 0.2 1.6e-05 25.0 0.0 2.2 2 0 0 2 2 2 1 ENTH domain PFK PF00365.20 AET39000.1 - 2.4e-186 617.7 1.5 3.1e-104 348.3 0.2 2.2 2 0 0 2 2 2 2 Phosphofructokinase Pfk_N PF18468.1 AET39000.1 - 5.8e-32 110.0 0.1 1.2e-31 109.0 0.1 1.6 1 0 0 1 1 1 1 Phosphofructokinase N-terminal domain yeast DAGK_cat PF00781.24 AET39000.1 - 0.0044 16.6 0.2 0.055 13.1 0.1 2.5 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain UVR PF02151.19 AET39000.1 - 0.15 11.8 0.1 0.15 11.8 0.1 2.6 3 0 0 3 3 3 0 UvrB/uvrC motif NTP_transf_2 PF01909.23 AET39001.1 - 1.7e-18 66.7 0.1 6.7e-18 64.8 0.0 2.1 2 0 0 2 2 2 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 AET39001.1 - 1.9e-14 53.6 0.1 5.4e-14 52.2 0.1 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase DNA_pol_B_palm PF14792.6 AET39001.1 - 0.11 12.7 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 DNA polymerase beta palm RF-1 PF00472.20 AET39002.1 - 2e-17 63.1 0.0 3.2e-17 62.5 0.0 1.2 1 0 0 1 1 1 1 RF-1 domain DUF3719 PF12516.8 AET39002.1 - 0.11 12.2 0.0 0.44 10.3 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3719) Pkinase PF00069.25 AET39003.1 - 4.3e-66 223.0 0.3 6.5e-65 219.1 0.2 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET39003.1 - 6.4e-51 173.1 0.1 9.9e-51 172.5 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 AET39003.1 - 6.8e-23 80.8 0.3 1.7e-22 79.5 0.3 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain PH PF00169.29 AET39003.1 - 1.5e-10 41.5 0.3 3e-10 40.5 0.3 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 AET39003.1 - 1e-06 28.3 0.0 1.7e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 AET39003.1 - 2.5e-06 26.6 1.6 4.4e-06 25.7 1.2 1.7 1 1 0 1 1 1 1 Fungal protein kinase PH_11 PF15413.6 AET39003.1 - 3.4e-06 27.4 0.4 9.6e-06 26.0 0.4 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain APH PF01636.23 AET39003.1 - 0.083 12.8 0.3 0.083 12.8 0.3 2.1 2 1 1 3 3 3 0 Phosphotransferase enzyme family DCB PF16213.5 AET39004.1 - 9.9e-48 162.1 2.1 9.9e-48 162.1 2.1 4.9 4 1 0 4 4 4 2 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 AET39004.1 - 8.6e-36 123.2 8.9 8.6e-36 123.2 8.9 5.2 4 1 1 5 5 5 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Mon2_C PF16206.5 AET39004.1 - 9.2e-15 53.9 0.6 3.9e-11 41.9 0.1 2.5 2 1 0 2 2 2 2 C-terminal region of Mon2 protein DUF1981 PF09324.10 AET39004.1 - 0.0053 16.6 0.1 0.11 12.4 0.0 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) Pet20 PF08692.10 AET39005.1 - 6.8e-05 23.6 1.8 0.00011 23.0 0.0 2.3 3 0 0 3 3 3 1 Mitochondrial protein Pet20 SH3-RhoG_link PF16609.5 AET39005.1 - 0.079 12.7 2.1 0.14 11.8 2.1 1.3 1 0 0 1 1 1 0 SH3-RhoGEF linking unstructured region PalH PF08733.10 AET39006.1 - 1.1e-78 264.6 6.1 1.5e-78 264.2 6.1 1.1 1 0 0 1 1 1 1 PalH/RIM21 Get5_bdg PF16843.5 AET39007.1 - 4.3e-26 90.2 0.7 8.3e-26 89.3 0.7 1.5 1 0 0 1 1 1 1 Binding domain to Get4 on Get5, Golgi to ER traffic protein Get5_C PF18514.1 AET39007.1 - 1.7e-12 46.9 0.9 2.4e-11 43.1 0.1 2.6 2 0 0 2 2 2 1 Get5 C-terminal domain ubiquitin PF00240.23 AET39007.1 - 2.3e-05 24.1 0.2 3.7e-05 23.4 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 AET39007.1 - 0.015 15.4 0.3 0.025 14.7 0.3 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Erf4 PF10256.9 AET39008.1 - 2.2e-30 105.1 0.0 2.9e-30 104.8 0.0 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family TruB_N PF01509.18 AET39009.1 - 2.8e-42 144.6 0.0 1.4e-39 135.9 0.0 2.4 1 1 0 2 2 2 2 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 AET39009.1 - 0.00064 19.8 0.0 0.0018 18.4 0.0 1.8 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain DNA_pol_B_thumb PF14791.6 AET39009.1 - 0.021 15.0 0.4 0.33 11.1 0.0 2.7 3 0 0 3 3 3 0 DNA polymerase beta thumb Mid1 PF12929.7 AET39010.1 - 4.6e-125 418.2 10.7 5.4e-125 417.9 10.7 1.0 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 AET39010.1 - 0.0004 21.0 3.4 0.016 15.8 3.4 2.6 1 1 0 1 1 1 1 Fz domain DUF4754 PF15946.5 AET39010.1 - 0.1 12.8 0.1 0.25 11.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4754) AAA PF00004.29 AET39011.1 - 1.4e-18 67.6 0.0 2.3e-18 66.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 AET39011.1 - 5.4e-17 62.0 0.1 1.4e-16 60.6 0.1 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 AET39011.1 - 3.1e-16 59.6 0.0 1e-11 44.9 0.1 2.3 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA_assoc_2 PF16193.5 AET39011.1 - 4.2e-09 36.6 0.1 1.3e-08 35.1 0.1 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_16 PF13191.6 AET39011.1 - 4.7e-07 30.4 0.2 1.5e-06 28.7 0.2 2.1 1 1 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 AET39011.1 - 1.2e-06 28.6 0.0 3.2e-06 27.2 0.0 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 AET39011.1 - 5.5e-06 26.2 0.0 1.1e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 AET39011.1 - 6.6e-06 26.4 0.4 0.17 12.2 0.1 2.6 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 AET39011.1 - 9.1e-06 25.5 0.1 0.00014 21.6 0.0 2.4 2 1 0 2 2 2 1 AAA domain DUF815 PF05673.13 AET39011.1 - 2.5e-05 23.6 0.0 4.2e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ResIII PF04851.15 AET39011.1 - 5.2e-05 23.3 0.0 0.013 15.5 0.0 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_14 PF13173.6 AET39011.1 - 5.4e-05 23.2 0.0 0.00012 22.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 AET39011.1 - 5.9e-05 22.9 0.0 0.00012 21.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AET39011.1 - 9.8e-05 22.4 0.0 0.0005 20.1 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_11 PF13086.6 AET39011.1 - 0.00011 22.0 0.1 0.00032 20.6 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_3 PF07726.11 AET39011.1 - 0.00032 20.6 0.0 0.00069 19.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 AET39011.1 - 0.00054 19.5 0.0 0.0011 18.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region DEAD PF00270.29 AET39011.1 - 0.00063 19.6 0.1 0.0025 17.6 0.1 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase DNA_pol3_delta PF06144.13 AET39011.1 - 0.00065 19.5 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_19 PF13245.6 AET39011.1 - 0.0007 20.0 0.6 0.2 12.0 0.0 3.1 2 1 1 3 3 3 1 AAA domain AAA_18 PF13238.6 AET39011.1 - 0.00094 19.7 0.0 0.0024 18.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 AET39011.1 - 0.002 17.6 0.1 0.026 13.9 0.0 2.3 2 1 0 2 2 1 1 Bacterial TniB protein Mg_chelatase PF01078.21 AET39011.1 - 0.0026 17.2 0.0 0.013 14.9 0.0 2.0 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 AET39011.1 - 0.0058 16.9 0.0 0.014 15.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 AET39011.1 - 0.0078 16.0 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 AET39011.1 - 0.0079 15.9 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 AET39011.1 - 0.0096 16.3 0.0 0.017 15.5 0.0 1.6 1 0 0 1 1 1 1 RNA helicase PhoH PF02562.16 AET39011.1 - 0.0097 15.4 0.1 3.5 7.0 0.0 2.3 1 1 0 2 2 2 1 PhoH-like protein DUF4442 PF14539.6 AET39011.1 - 0.0097 16.0 0.0 0.44 10.7 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4442) ATPase_2 PF01637.18 AET39011.1 - 0.024 14.6 0.0 0.052 13.5 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 AET39011.1 - 0.033 13.8 0.1 0.71 9.4 0.0 2.3 1 1 1 2 2 2 0 AAA domain SRP54 PF00448.22 AET39011.1 - 0.036 13.7 0.0 0.067 12.8 0.0 1.5 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 AET39011.1 - 0.055 13.6 0.3 0.17 12.0 0.3 2.0 1 1 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.9 AET39011.1 - 0.073 12.0 0.0 0.22 10.4 0.0 1.7 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain T2SSE PF00437.20 AET39011.1 - 0.081 12.0 0.2 2.9 6.9 0.0 2.2 1 1 0 2 2 2 0 Type II/IV secretion system protein MeaB PF03308.16 AET39011.1 - 0.085 11.8 0.0 1.2 8.0 0.0 2.4 2 1 1 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB HAD_2 PF13419.6 AET39011.1 - 0.1 12.7 0.1 0.57 10.2 0.1 2.4 2 2 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF2075 PF09848.9 AET39011.1 - 0.11 11.7 0.1 0.34 10.1 0.1 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) SNF2_N PF00176.23 AET39011.1 - 0.12 11.1 0.0 0.18 10.5 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain Cyclin_N PF00134.23 AET39012.1 - 1.1e-18 67.2 0.0 1.9e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 AET39012.1 - 1.1e-07 32.4 0.0 1.6e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 Cyclin Rcd1 PF04078.13 AET39014.1 - 5.6e-116 386.4 5.2 7.2e-116 386.0 5.2 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like TFIIA PF03153.13 AET39014.1 - 1 9.3 13.3 1.8 8.5 13.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Adaptin_N PF01602.20 AET39015.1 - 1e-104 351.0 7.7 1.3e-104 350.7 7.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 AET39015.1 - 1.6e-48 164.7 2.1 3.6e-48 163.5 2.1 1.7 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 AET39015.1 - 7.6e-26 90.5 0.1 1.8e-25 89.3 0.1 1.7 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 AET39015.1 - 1.2e-11 44.8 0.0 0.00011 22.5 0.0 4.6 3 1 1 4 4 4 3 HEAT repeats HEAT PF02985.22 AET39015.1 - 0.0022 18.1 3.4 55 4.4 0.0 6.2 6 0 0 6 6 6 0 HEAT repeat HAMP_N3 PF18575.1 AET39015.1 - 0.16 11.6 0.0 13 5.5 0.0 2.5 2 0 0 2 2 2 0 HAMP N-terminal domain 3 Ribosomal_L27A PF00828.19 AET39016.1 - 2.3e-32 112.3 0.4 3.7e-32 111.7 0.4 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A HLH PF00010.26 AET39017.1 - 0.00011 22.1 0.2 0.00023 21.1 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Bac_GDH PF05088.12 AET39017.1 - 0.011 13.3 0.4 0.011 13.2 0.4 1.0 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase ADH_zinc_N PF00107.26 AET39018.1 - 3.3e-09 36.8 0.0 5.6e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF4974 PF16344.5 AET39018.1 - 0.0043 17.0 0.0 0.01 15.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4974) FIBP PF05427.11 AET39018.1 - 0.021 14.2 0.0 0.03 13.6 0.0 1.2 1 0 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) Mannosyl_trans3 PF11051.8 AET39019.1 - 4.1e-57 193.6 0.0 1.9e-56 191.4 0.0 2.0 2 0 0 2 2 2 1 Mannosyltransferase putative MtN3_slv PF03083.16 AET39019.1 - 0.018 15.1 0.1 0.045 13.8 0.1 1.6 1 0 0 1 1 1 0 Sugar efflux transporter for intercellular exchange Pkinase PF00069.25 AET39021.1 - 8.8e-60 202.3 0.0 5.1e-59 199.8 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET39021.1 - 6.5e-32 110.8 0.0 7.5e-31 107.4 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET39021.1 - 0.0014 18.0 0.0 0.048 13.0 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_C PF00433.24 AET39021.1 - 0.31 11.8 4.4 1.2 9.9 4.4 2.1 1 1 0 1 1 1 0 Protein kinase C terminal domain CTP_transf_1 PF01148.20 AET39022.1 - 5.8e-79 265.6 18.1 8.2e-79 265.1 18.1 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family DUF3449 PF11931.8 AET39023.1 - 2.8e-68 229.3 0.1 2.8e-68 229.3 0.1 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF3449) PRP9_N PF16958.5 AET39023.1 - 7e-50 169.0 14.3 1.9e-49 167.6 14.3 1.7 1 0 0 1 1 1 1 Pre-mRNA-splicing factor PRP9 N-terminus SF3A3 PF16837.5 AET39023.1 - 2.1e-15 57.0 1.4 2.1e-15 57.0 1.4 2.5 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-met PF12874.7 AET39023.1 - 0.00017 21.8 6.5 0.00034 20.9 0.1 3.5 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AET39023.1 - 0.00048 20.3 0.1 0.00048 20.3 0.1 4.1 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 AET39023.1 - 0.0013 19.0 2.9 0.059 13.7 0.1 3.1 2 1 0 2 2 2 1 C2H2 type zinc-finger (2 copies) Anillin_N PF16018.5 AET39023.1 - 0.04 14.5 0.0 0.11 13.1 0.0 1.8 1 0 0 1 1 1 0 Anillin N-terminus DUF3450 PF11932.8 AET39023.1 - 0.38 10.0 0.0 0.38 10.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF2175 PF09943.9 AET39023.1 - 3.6 7.9 6.7 9.6 6.6 0.0 3.4 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) UpxZ PF06603.11 AET39023.1 - 3.8 7.9 6.0 3.4 8.0 0.3 3.0 3 0 0 3 3 3 0 UpxZ family of transcription anti-terminator antagonists tRNA_Me_trans PF03054.16 AET39024.1 - 5.2e-116 387.3 0.0 5.9e-116 387.1 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.17 AET39024.1 - 0.0087 15.2 0.0 0.17 10.9 0.0 2.4 2 1 0 2 2 2 1 NAD synthase Asn_synthase PF00733.21 AET39024.1 - 0.12 12.0 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase Inositol_P PF00459.25 AET39025.1 - 2.1e-48 165.2 0.0 3e-48 164.7 0.0 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family EF_assoc_1 PF08355.12 AET39025.1 - 0.054 13.1 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 EF hand associated Exo_endo_phos PF03372.23 AET39026.1 - 3e-06 26.9 0.0 5.5e-06 26.1 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Inv-AAD PF18785.1 AET39027.1 - 3.8e-37 127.0 0.0 7.8e-37 126.0 0.0 1.6 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase PseudoU_synth_2 PF00849.22 AET39027.1 - 1.4e-31 109.7 0.0 2.4e-31 109.0 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase dCMP_cyt_deam_1 PF00383.23 AET39027.1 - 7.5e-19 67.5 0.0 1.8e-18 66.3 0.0 1.7 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 AET39027.1 - 0.0001 22.1 0.0 0.00018 21.3 0.0 1.4 1 0 0 1 1 1 1 MafB19-like deaminase NARP1 PF12569.8 AET39028.1 - 2.1e-111 373.4 28.6 3.6e-78 263.8 8.7 3.0 3 0 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 AET39028.1 - 7.2e-13 47.6 13.7 0.00036 20.4 0.1 6.8 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 AET39028.1 - 2.1e-11 43.6 0.3 0.0088 16.8 0.0 5.5 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 AET39028.1 - 1.4e-09 37.4 7.9 0.0042 16.8 0.1 5.9 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 AET39028.1 - 3e-08 34.2 0.2 0.41 11.3 0.0 5.4 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 AET39028.1 - 6e-08 32.3 14.7 0.035 14.3 0.0 7.5 8 0 0 8 8 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 AET39028.1 - 5.8e-07 29.7 14.1 0.0078 16.4 0.1 4.8 5 0 0 5 5 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 AET39028.1 - 3.1e-06 27.6 2.3 0.41 11.2 0.1 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 AET39028.1 - 4.1e-05 23.8 3.9 2.4 8.5 0.1 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 AET39028.1 - 0.00024 20.9 3.3 16 5.8 0.0 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.6 AET39028.1 - 0.00033 20.8 5.4 0.13 12.7 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 AET39028.1 - 0.0067 17.0 7.4 0.52 11.1 0.0 5.5 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 AET39028.1 - 0.021 14.5 0.1 0.021 14.5 0.1 3.5 5 0 0 5 5 5 0 TPR repeat Fis1_TPR_C PF14853.6 AET39028.1 - 0.036 14.2 8.7 0.35 11.0 0.4 4.3 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 AET39028.1 - 0.38 10.7 3.2 9.2 6.3 0.0 4.1 5 0 0 5 5 3 0 Tetratricopeptide repeat Arrestin_C PF02752.22 AET39029.1 - 5.5e-23 81.9 0.0 1.6e-22 80.4 0.0 1.8 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 AET39029.1 - 7.4e-10 39.1 0.0 2.2e-08 34.3 0.0 2.4 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 AET39029.1 - 0.0071 16.1 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 Arrestin_N terminal like Memo PF01875.17 AET39029.1 - 0.084 12.0 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Memo-like protein WD40 PF00400.32 AET39030.1 - 1.9e-07 31.7 0.0 0.034 15.0 0.0 2.9 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET39030.1 - 8.4e-06 26.0 0.0 0.068 13.5 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AET39030.1 - 0.013 14.5 0.2 0.06 12.3 0.0 2.0 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF676 PF05057.14 AET39031.1 - 1.9e-41 142.0 0.1 2.7e-41 141.5 0.1 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 AET39031.1 - 3.3e-07 30.4 0.0 5.9e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 AET39031.1 - 0.00056 19.7 0.1 0.00099 18.9 0.1 1.4 1 0 0 1 1 1 1 PGAP1-like protein CBP_BcsG PF11658.8 AET39031.1 - 0.042 12.3 0.3 0.061 11.7 0.3 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG LRR19-TM PF15176.6 AET39031.1 - 0.08 12.9 0.1 18 5.4 0.0 2.4 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain Sedlin_N PF04628.13 AET39032.1 - 8.1e-07 29.2 0.1 1e-06 28.9 0.1 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region FAD_binding_2 PF00890.24 AET39033.1 - 2e-71 241.3 0.0 2.3e-71 241.1 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 AET39033.1 - 1.1e-07 31.8 0.1 2e-06 27.6 0.1 2.5 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 AET39033.1 - 1.2e-07 31.8 0.0 3.2e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 AET39033.1 - 2e-05 24.0 1.2 0.0001 21.7 0.3 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 AET39033.1 - 0.00019 20.3 2.9 0.02 13.6 0.2 3.2 2 1 0 3 3 3 2 HI0933-like protein Thi4 PF01946.17 AET39033.1 - 0.00021 20.6 1.1 0.01 15.1 0.1 2.3 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 AET39033.1 - 0.0011 18.1 0.2 0.69 8.9 0.2 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_binding_3 PF01494.19 AET39033.1 - 0.0019 17.5 0.4 0.0036 16.6 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 AET39033.1 - 0.0051 16.2 0.0 0.012 15.0 0.0 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 AET39033.1 - 0.01 15.1 0.1 1.5 8.0 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 AET39033.1 - 0.044 12.9 1.1 0.15 11.1 0.0 2.3 3 0 0 3 3 3 0 Glucose inhibited division protein A Beta_elim_lyase PF01212.21 AET39034.1 - 7.5e-80 268.3 0.0 8.9e-80 268.1 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase YL1_C PF08265.11 AET39035.1 - 1.2e-14 53.7 0.7 1.7e-13 50.1 0.1 2.2 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain DUF3536 PF12055.8 AET39035.1 - 0.14 11.4 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3536) fn3 PF00041.21 AET39036.1 - 0.0012 19.1 0.2 0.0053 17.1 0.0 2.2 2 0 0 2 2 2 1 Fibronectin type III domain RNase_HII PF01351.18 AET39036.1 - 0.068 13.0 3.2 0.16 11.8 3.2 1.7 1 0 0 1 1 1 0 Ribonuclease HII V_ATPase_I PF01496.19 AET39036.1 - 0.21 9.4 8.9 0.33 8.8 8.6 1.5 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Syntaxin-6_N PF09177.11 AET39036.1 - 2.6 8.7 12.6 0.37 11.4 1.8 3.7 3 0 0 3 3 3 0 Syntaxin 6, N-terminal DASH_Dad4 PF08650.10 AET39036.1 - 3.6 7.6 10.4 5.6 7.0 0.6 3.2 2 1 1 3 3 3 0 DASH complex subunit Dad4 Isy1 PF06246.12 AET39037.1 - 1.6e-55 188.4 17.3 9.2e-55 186.0 17.3 1.8 1 1 0 1 1 1 1 Isy1-like splicing family SAM_DrpA PF18255.1 AET39037.1 - 0.0023 18.1 0.0 0.0056 16.9 0.0 1.6 1 0 0 1 1 1 1 DNA processing protein A sterile alpha motif domain DivIC PF04977.15 AET39037.1 - 0.093 12.5 5.2 0.94 9.3 0.9 2.9 3 0 0 3 3 3 0 Septum formation initiator TssO PF17561.2 AET39037.1 - 4.2 7.5 9.6 0.74 9.9 1.4 2.4 2 0 0 2 2 2 0 Type VI secretion system, TssO Snf7 PF03357.21 AET39037.1 - 5 6.7 9.5 4.1 7.0 0.0 2.5 2 1 0 2 2 2 0 Snf7 GDA1_CD39 PF01150.17 AET39038.1 - 2e-109 366.1 0.0 2.6e-109 365.7 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family RNA_pol_Rpb1_4 PF05000.17 AET39038.1 - 0.017 15.0 0.0 0.034 14.1 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 4 NAD_kinase PF01513.21 AET39039.1 - 4e-84 282.3 0.0 5.5e-84 281.8 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 AET39039.1 - 0.00062 19.4 0.0 0.0024 17.5 0.0 1.9 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain Spot_14 PF07084.12 AET39039.1 - 0.086 13.0 0.6 0.35 11.0 0.1 2.0 2 0 0 2 2 2 0 Thyroid hormone-inducible hepatic protein Spot 14 Cytochrom_C PF00034.21 AET39040.1 - 1.8e-09 38.6 0.4 3.2e-09 37.8 0.4 1.3 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 AET39040.1 - 1.3e-06 28.6 3.3 9.8e-06 25.8 3.3 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 AET39040.1 - 0.025 14.3 0.5 0.19 11.5 0.1 2.1 2 0 0 2 2 2 0 Cytochrome c-550 domain Hydrolase PF00702.26 AET39041.1 - 0.0007 19.9 0.1 0.0094 16.3 0.1 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AET39041.1 - 0.076 13.1 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase UBA PF00627.31 AET39042.1 - 4.9e-26 90.2 1.7 4.5e-15 55.2 0.4 2.5 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.23 AET39042.1 - 2.7e-15 55.8 0.5 4.7e-15 55.1 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin family XPC-binding PF09280.11 AET39042.1 - 7.5e-10 38.4 0.3 1.3e-09 37.6 0.3 1.3 1 0 0 1 1 1 1 XPC-binding domain Rad60-SLD PF11976.8 AET39042.1 - 1.3e-05 25.0 0.4 1.3e-05 25.0 0.4 1.6 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 AET39042.1 - 0.0002 21.9 0.0 0.0004 20.9 0.0 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 AET39042.1 - 0.00024 21.2 0.1 0.00051 20.1 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 AET39042.1 - 0.0016 18.7 0.5 0.0029 17.9 0.5 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain DUF1421 PF07223.11 AET39042.1 - 0.0022 17.8 0.1 0.58 10.0 0.0 3.0 3 0 0 3 3 3 1 UBA-like domain (DUF1421) CUE PF02845.16 AET39042.1 - 0.012 15.3 1.3 5.4 6.8 0.0 3.8 3 1 0 3 3 3 0 CUE domain UBA_3 PF09288.10 AET39042.1 - 0.079 12.8 0.0 5.2 7.0 0.0 2.4 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain HEAT PF02985.22 AET39042.1 - 0.16 12.3 0.0 0.45 10.9 0.0 1.8 1 0 0 1 1 1 0 HEAT repeat Anp1 PF03452.14 AET39043.1 - 7.4e-113 376.3 0.0 1.3e-112 375.5 0.0 1.4 1 0 0 1 1 1 1 Anp1 eIF-5a PF01287.20 AET39044.1 - 1e-29 102.4 0.5 1.4e-29 102.0 0.5 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 AET39044.1 - 0.0029 17.6 0.0 0.0049 16.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain MCM PF00493.23 AET39045.1 - 7.6e-96 319.5 0.2 1.1e-95 319.0 0.2 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AET39045.1 - 9.8e-31 106.2 0.0 1.9e-30 105.3 0.0 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AET39045.1 - 8.5e-25 87.0 0.8 1.7e-24 86.1 0.8 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 AET39045.1 - 4.3e-08 32.8 0.0 1.9e-06 27.4 0.0 3.0 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 AET39045.1 - 0.00035 21.1 0.0 0.0027 18.3 0.0 2.4 1 1 0 1 1 1 1 MCM N-terminal domain AAA_3 PF07726.11 AET39045.1 - 0.0024 17.8 0.0 0.0052 16.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 AET39045.1 - 0.0076 16.0 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 AET39045.1 - 0.14 12.1 0.0 0.42 10.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) E1-E2_ATPase PF00122.20 AET39046.1 - 6.8e-17 61.6 0.1 6.8e-17 61.6 0.1 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 AET39046.1 - 8.4e-17 62.2 0.0 1.6e-10 41.6 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AET39046.1 - 0.00017 21.6 0.0 0.0004 20.4 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 AET39046.1 - 0.0086 15.8 0.0 0.064 13.0 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase CDT1_C PF16679.5 AET39047.1 - 1.3e-07 32.0 0.1 3.5e-07 30.6 0.1 1.8 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain Med10 PF09748.9 AET39047.1 - 0.038 13.9 0.3 0.73 9.8 0.2 2.6 1 1 1 2 2 2 0 Transcription factor subunit Med10 of Mediator complex HupF_HypC PF01455.18 AET39047.1 - 0.14 12.3 0.0 0.32 11.2 0.0 1.5 1 0 0 1 1 1 0 HupF/HypC family HSP70 PF00012.20 AET39048.1 - 1e-263 876.0 15.7 1.1e-263 875.9 15.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AET39048.1 - 3.9e-16 58.8 5.7 1.6e-14 53.5 2.7 2.4 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 AET39048.1 - 0.00052 19.8 0.0 0.0016 18.2 0.0 1.8 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Syntaxin_2 PF14523.6 AET39048.1 - 0.01 16.2 6.4 0.016 15.6 4.3 2.3 1 1 1 2 2 2 0 Syntaxin-like protein ALO PF04030.14 AET39048.1 - 0.18 11.6 0.0 0.35 10.6 0.0 1.4 1 0 0 1 1 1 0 D-arabinono-1,4-lactone oxidase YlbD_coat PF14071.6 AET39048.1 - 0.19 12.0 5.1 0.6 10.4 5.1 1.9 1 0 0 1 1 1 0 Putative coat protein FtsA PF14450.6 AET39048.1 - 0.26 11.7 8.2 0.84 10.1 0.4 4.1 3 2 0 3 3 3 0 Cell division protein FtsA Mnd1 PF03962.15 AET39048.1 - 0.53 10.6 1.8 6.6 7.1 0.7 2.7 2 0 0 2 2 2 0 Mnd1 HTH domain DUF948 PF06103.11 AET39048.1 - 1.9 8.8 4.7 2.3 8.6 2.3 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Vps55 PF04133.14 AET39049.1 - 1.6e-38 131.2 4.4 1.9e-38 131.0 4.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF2614 PF11023.8 AET39049.1 - 0.77 9.9 5.0 1.5 8.9 0.6 2.1 2 0 0 2 2 2 0 Zinc-ribbon containing domain WD40 PF00400.32 AET39050.1 - 0.0047 17.7 0.6 2.2 9.3 0.1 3.9 3 0 0 3 3 3 1 WD domain, G-beta repeat PID PF00640.23 AET39050.1 - 0.083 12.9 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Cupin_4 PF08007.12 AET39050.1 - 0.16 11.4 0.1 0.27 10.6 0.1 1.3 1 0 0 1 1 1 0 Cupin superfamily protein SLD5_C PF16922.5 AET39051.1 - 1e-19 70.4 0.0 2.2e-19 69.4 0.0 1.6 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 AET39051.1 - 3.6e-08 33.8 1.5 1.3e-07 32.1 1.4 2.0 2 1 0 2 2 2 1 GINS complex protein Peptidase_M16_C PF05193.21 AET39052.1 - 3.1e-20 73.0 0.0 1.3e-17 64.4 0.0 3.6 4 0 0 4 4 4 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 AET39052.1 - 4.9e-07 29.8 0.0 1.2e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) UPF0180 PF03698.13 AET39052.1 - 0.089 13.0 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0180) RQC PF09382.10 AET39052.1 - 0.18 11.6 0.0 0.45 10.3 0.0 1.6 1 0 0 1 1 1 0 RQC domain Pkinase PF00069.25 AET39053.1 - 4.2e-62 209.9 0.1 6.3e-62 209.3 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET39053.1 - 1.4e-33 116.3 0.0 2.5e-33 115.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET39053.1 - 1.5e-07 31.1 0.0 2.3e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 AET39053.1 - 0.0001 21.2 0.4 0.0013 17.5 0.0 2.3 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 AET39053.1 - 0.00014 21.3 0.0 0.00027 20.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 AET39053.1 - 0.0015 18.2 0.3 0.46 10.1 0.0 2.6 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 AET39053.1 - 0.0038 16.2 0.2 0.0038 16.2 0.2 1.6 2 0 0 2 2 2 1 Haspin like kinase domain Peptidase_M35 PF02102.15 AET39053.1 - 0.019 13.8 3.8 0.031 13.2 3.8 1.2 1 0 0 1 1 1 0 Deuterolysin metalloprotease (M35) family APH PF01636.23 AET39053.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family HlyIII PF03006.20 AET39055.1 - 2.1e-52 178.1 23.6 2.5e-52 177.8 23.6 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF3493 PF11998.8 AET39055.1 - 0.56 10.4 2.5 1.5 9.0 2.5 1.8 1 1 0 1 1 1 0 Low psii accumulation1 / Rep27 PTS_2-RNA PF01885.16 AET39056.1 - 2.2e-57 194.0 1.0 2.9e-57 193.7 1.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family PARP PF00644.20 AET39056.1 - 0.0079 15.8 0.1 0.013 15.1 0.1 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Vps39_2 PF10367.9 AET39058.1 - 1.5 9.3 3.4 1.9 9.0 0.4 2.8 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 CPL PF08144.11 AET39059.1 - 1.3e-47 161.7 3.2 1.4e-44 151.9 0.0 4.6 4 2 2 6 6 6 1 CPL (NUC119) domain PUF PF00806.19 AET39059.1 - 7.7e-07 28.5 2.4 0.43 10.4 0.0 5.9 6 0 0 6 6 6 2 Pumilio-family RNA binding repeat DUF2294 PF10057.9 AET39059.1 - 0.013 15.6 0.7 2.1 8.5 0.1 3.8 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2294) SAC3 PF12209.8 AET39059.1 - 0.073 13.3 4.2 13 6.0 0.0 4.3 3 1 1 4 4 4 0 Leucine permease transcriptional regulator helical domain 3H PF02829.14 AET39059.1 - 0.32 11.3 2.6 0.85 10.0 0.3 2.8 3 0 0 3 3 3 0 3H domain YL1 PF05764.13 AET39059.1 - 1.6 8.8 10.6 3.4 7.7 10.6 1.5 1 0 0 1 1 1 0 YL1 nuclear protein Sec20 PF03908.13 AET39060.1 - 3.8e-23 81.2 1.9 3.8e-23 81.2 1.9 2.5 2 0 0 2 2 2 1 Sec20 V-SNARE_C PF12352.8 AET39060.1 - 0.0021 18.3 10.4 0.16 12.3 0.1 3.5 2 1 0 2 2 2 2 Snare region anchored in the vesicle membrane C-terminus SRI PF08236.11 AET39061.1 - 0.098 12.8 2.3 2.7 8.2 0.2 2.8 3 0 0 3 3 3 0 SRI (Set2 Rpb1 interacting) domain ERG4_ERG24 PF01222.17 AET39062.1 - 5.5e-162 539.4 17.2 6.2e-162 539.2 17.2 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 AET39062.1 - 0.00037 20.1 0.6 0.00095 18.7 0.6 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PPTA PF01239.22 AET39062.1 - 0.18 11.5 3.0 1.1 9.0 0.0 2.7 2 0 0 2 2 2 0 Protein prenyltransferase alpha subunit repeat Aha1_N PF09229.11 AET39063.1 - 3e-29 102.0 0.5 4.5e-29 101.4 0.5 1.3 1 1 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal RNase_P_pop3 PF08228.11 AET39064.1 - 2.9e-43 147.6 0.0 3.5e-43 147.4 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 SieB PF14163.6 AET39064.1 - 0.051 13.1 0.0 0.071 12.6 0.0 1.2 1 0 0 1 1 1 0 Super-infection exclusion protein B WSC PF01822.19 AET39065.1 - 8.9e-10 38.6 11.3 8.9e-10 38.6 11.3 2.7 2 1 0 2 2 2 1 WSC domain Podoplanin PF05808.11 AET39065.1 - 0.00027 21.1 9.8 0.00027 21.1 9.8 2.6 1 1 1 2 2 2 1 Podoplanin Mid2 PF04478.12 AET39065.1 - 0.032 14.1 1.0 0.032 14.1 1.0 2.7 2 1 1 3 3 3 0 Mid2 like cell wall stress sensor GREB1 PF15782.5 AET39065.1 - 0.39 7.8 19.1 0.46 7.6 19.1 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hid1 PF12722.7 AET39065.1 - 5.4 5.0 12.7 6.9 4.7 12.7 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Transp_cyt_pur PF02133.15 AET39066.1 - 8.7e-152 505.9 36.3 1e-151 505.7 36.3 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin ABC2_membrane PF01061.24 AET39067.1 - 3e-63 213.1 57.8 1.8e-36 125.6 17.6 2.6 3 0 0 3 3 2 2 ABC-2 type transporter ABC_tran PF00005.27 AET39067.1 - 1.6e-40 138.8 0.0 2.5e-19 70.1 0.0 3.1 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 AET39067.1 - 1.1e-33 115.0 9.7 1.2e-30 105.2 0.0 3.2 3 0 0 3 3 2 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 AET39067.1 - 1.1e-07 31.3 37.5 3.6e-06 26.3 16.3 3.3 2 2 1 3 3 3 2 ABC-2 family transporter protein RsgA_GTPase PF03193.16 AET39067.1 - 1.5e-06 28.3 0.1 0.00048 20.1 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 AET39067.1 - 5.6e-05 23.6 0.1 0.034 14.5 0.1 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 AET39067.1 - 6.6e-05 22.9 0.0 0.14 11.9 0.0 2.5 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC_trans_N PF14510.6 AET39067.1 - 8.2e-05 23.1 0.0 0.00021 21.9 0.0 1.6 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_22 PF13401.6 AET39067.1 - 0.0011 19.2 0.0 0.023 15.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 AET39067.1 - 0.0012 18.9 1.8 0.17 11.9 0.2 2.9 3 0 0 3 3 2 1 50S ribosome-binding GTPase SMC_N PF02463.19 AET39067.1 - 0.0017 17.8 0.0 0.096 12.1 0.0 3.0 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 AET39067.1 - 0.0044 16.7 0.1 0.23 11.2 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 AET39067.1 - 0.0057 17.2 0.0 0.07 13.7 0.0 2.7 3 0 0 3 3 2 1 AAA domain HalX PF08663.10 AET39067.1 - 0.01 16.1 3.0 0.27 11.6 1.0 2.6 2 0 0 2 2 2 0 HalX domain Dynamin_N PF00350.23 AET39067.1 - 0.014 15.4 1.2 0.092 12.8 0.0 2.6 3 0 0 3 3 3 0 Dynamin family cobW PF02492.19 AET39067.1 - 0.017 14.7 0.7 0.042 13.4 0.1 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 AET39067.1 - 0.036 13.6 0.1 0.091 12.3 0.1 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 AET39067.1 - 0.055 13.4 0.6 0.49 10.3 0.1 2.3 2 0 0 2 2 2 0 NACHT domain Septin PF00735.18 AET39067.1 - 0.11 11.7 1.7 0.28 10.4 0.1 2.3 2 0 0 2 2 2 0 Septin AAA_24 PF13479.6 AET39067.1 - 0.13 11.9 0.0 0.5 10.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 AET39067.1 - 0.15 12.3 0.1 0.41 10.9 0.1 1.7 1 0 0 1 1 1 0 AAA domain TrpP PF17099.5 AET39067.1 - 0.18 11.6 4.5 4.3 7.1 0.0 3.0 3 0 0 3 3 2 0 Tryptophan transporter TrpP ABC_ATPase PF09818.9 AET39067.1 - 0.2 10.4 0.2 0.34 9.6 0.2 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_30 PF13604.6 AET39067.1 - 0.23 11.2 0.3 3.9 7.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 AET39067.1 - 0.42 11.1 8.0 0.67 10.4 0.3 2.6 3 0 0 3 3 2 0 AAA domain DASH_Spc34 PF08657.10 AET39067.1 - 0.48 10.2 2.4 1.2 8.9 2.4 1.5 1 0 0 1 1 1 0 DASH complex subunit Spc34 TMIE PF16038.5 AET39067.1 - 1.4 8.9 3.8 0.72 9.7 0.4 2.4 2 0 0 2 2 1 0 TMIE protein ABC2_membrane PF01061.24 AET39068.1 - 5.1e-82 274.4 62.2 1.6e-46 158.4 22.7 3.0 4 0 0 4 4 4 2 ABC-2 type transporter PDR_CDR PF06422.12 AET39068.1 - 9.2e-33 112.0 0.2 9.2e-33 112.0 0.2 4.2 4 0 0 4 4 4 2 CDR ABC transporter ABC_tran PF00005.27 AET39068.1 - 1.4e-29 103.3 0.0 8.1e-16 58.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_trans_N PF14510.6 AET39068.1 - 8.3e-15 55.2 0.1 3.9e-14 53.0 0.0 2.2 2 0 0 2 2 2 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 AET39068.1 - 1.5e-05 25.0 0.0 0.0037 17.2 0.0 2.9 3 0 0 3 3 3 1 RsgA GTPase ABC2_membrane_3 PF12698.7 AET39068.1 - 1.5e-05 24.3 50.9 0.0042 16.3 14.0 3.6 2 2 1 3 3 3 2 ABC-2 family transporter protein AAA_16 PF13191.6 AET39068.1 - 5.3e-05 23.7 0.0 0.0075 16.7 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 AET39068.1 - 0.00087 19.8 0.0 0.019 15.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 AET39068.1 - 0.00092 19.5 0.1 0.18 12.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AET39068.1 - 0.0011 19.3 0.1 0.075 13.3 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_25 PF13481.6 AET39068.1 - 0.002 17.7 1.4 0.0042 16.7 0.3 2.1 2 1 1 3 3 3 1 AAA domain dNK PF01712.19 AET39068.1 - 0.0028 17.6 0.0 1.6 8.6 0.0 2.5 2 0 0 2 2 2 2 Deoxynucleoside kinase AAA_29 PF13555.6 AET39068.1 - 0.0058 16.3 0.3 0.059 13.1 0.1 2.6 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_21 PF13304.6 AET39068.1 - 0.055 13.3 0.4 7.5 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system cobW PF02492.19 AET39068.1 - 0.06 12.9 0.4 0.24 11.0 0.1 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 AET39068.1 - 0.09 12.5 0.3 5.5 6.7 0.3 2.4 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 AET39068.1 - 0.1 12.7 0.2 6.3 6.9 0.1 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.12 AET39068.1 - 0.11 12.4 0.5 3.1 7.7 0.0 3.0 3 0 0 3 3 3 0 NACHT domain SMC_N PF02463.19 AET39068.1 - 0.13 11.7 0.0 2 7.8 0.0 2.4 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Chitin_synth_2 PF03142.15 AET39069.1 - 1.4e-273 908.4 0.4 2.4e-273 907.6 0.4 1.3 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 AET39069.1 - 1.3e-12 48.1 1.3 5.4e-12 46.0 1.3 2.1 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 AET39069.1 - 1.7e-11 44.4 0.0 5.8e-10 39.5 0.0 2.4 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 AET39069.1 - 0.00041 19.9 0.0 0.0014 18.1 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 AET39069.1 - 0.001 18.9 0.0 0.025 14.4 0.0 2.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 SCO1-SenC PF02630.14 AET39070.1 - 4.9e-47 159.2 0.0 7.1e-47 158.7 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 AET39070.1 - 0.016 15.1 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family YchF-GTPase_C PF06071.13 AET39071.1 - 1.3e-36 124.6 1.1 2.5e-36 123.7 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 AET39071.1 - 2.5e-17 63.0 0.0 1.3e-16 60.7 0.0 2.1 1 1 1 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.21 AET39071.1 - 0.0011 19.0 0.0 0.0026 17.8 0.0 1.6 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 AET39071.1 - 0.0061 16.1 0.0 0.017 14.7 0.0 1.7 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 AET39071.1 - 0.27 11.8 1.4 32 5.1 0.4 2.9 3 0 0 3 3 3 0 AAA domain PEMT PF04191.13 AET39072.1 - 1.5e-31 108.9 3.4 1.5e-31 108.9 3.4 1.6 2 0 0 2 2 2 1 Phospholipid methyltransferase ABC_membrane PF00664.23 AET39073.1 - 1e-96 323.8 27.0 5e-52 177.2 6.8 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 AET39073.1 - 1.1e-58 197.6 1.8 2.4e-28 99.4 0.0 3.2 4 0 0 4 4 3 2 ABC transporter SMC_N PF02463.19 AET39073.1 - 1.8e-15 57.0 4.8 1.1e-05 25.0 0.0 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 AET39073.1 - 1.3e-09 37.7 0.2 0.00044 19.9 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.9 AET39073.1 - 1.7e-08 33.7 0.8 0.0068 15.2 0.0 3.3 3 0 0 3 3 3 2 Predicted ATPase of the ABC class IstB_IS21 PF01695.17 AET39073.1 - 4.4e-06 26.5 0.4 3.1 7.5 0.0 4.8 5 0 0 5 5 5 2 IstB-like ATP binding protein AAA_22 PF13401.6 AET39073.1 - 5.1e-06 26.8 2.4 0.0094 16.2 0.2 3.6 3 1 0 3 3 3 2 AAA domain AAA_23 PF13476.6 AET39073.1 - 6.3e-06 26.8 0.7 0.078 13.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 AET39073.1 - 1.5e-05 24.9 0.0 0.0095 15.8 0.0 2.8 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 AET39073.1 - 5.6e-05 23.6 0.6 0.047 14.1 0.0 2.9 3 0 0 3 3 2 1 AAA ATPase domain CbiA PF01656.23 AET39073.1 - 0.00011 22.2 0.2 0.62 10.1 0.0 2.5 2 0 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain DUF87 PF01935.17 AET39073.1 - 0.00014 22.1 1.9 0.11 12.6 0.0 2.8 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_5 PF07728.14 AET39073.1 - 0.0014 18.6 0.0 0.74 9.8 0.0 2.8 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 AET39073.1 - 0.0015 19.1 0.1 0.097 13.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 AET39073.1 - 0.0016 18.2 3.0 0.15 11.8 0.3 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_24 PF13479.6 AET39073.1 - 0.0018 18.0 0.2 1.8 8.3 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_13 PF13166.6 AET39073.1 - 0.0019 16.9 0.3 0.54 8.8 0.1 2.5 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 AET39073.1 - 0.0025 17.9 0.9 0.25 11.4 0.1 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase NB-ARC PF00931.22 AET39073.1 - 0.0026 17.0 0.2 0.19 10.9 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain DUF3987 PF13148.6 AET39073.1 - 0.0036 16.4 0.0 0.14 11.2 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3987) FtsK_SpoIIIE PF01580.18 AET39073.1 - 0.0052 16.2 0.0 1.7 7.9 0.0 2.6 2 0 0 2 2 2 1 FtsK/SpoIIIE family RNA_helicase PF00910.22 AET39073.1 - 0.0058 17.0 0.1 0.58 10.6 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_30 PF13604.6 AET39073.1 - 0.0085 15.8 0.0 1.4 8.6 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 AET39073.1 - 0.011 15.9 0.1 0.46 10.6 0.1 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 AET39073.1 - 0.014 14.7 0.0 0.24 10.6 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_21 PF13304.6 AET39073.1 - 0.062 13.1 7.7 1.3 8.8 0.1 3.5 3 1 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 AET39073.1 - 0.071 13.0 1.0 10 6.0 0.0 3.4 3 0 0 3 3 3 0 NACHT domain ATPase PF06745.13 AET39073.1 - 0.075 12.4 0.4 14 4.9 0.0 2.5 2 0 0 2 2 2 0 KaiC Pox_A32 PF04665.12 AET39073.1 - 0.16 11.4 2.0 6.6 6.1 0.2 2.5 2 0 0 2 2 2 0 Poxvirus A32 protein ThiF PF00899.21 AET39074.1 - 1.3e-103 345.7 0.0 4.9e-73 245.5 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 AET39074.1 - 5.2e-86 288.7 0.2 7.8e-86 288.1 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 AET39074.1 - 7.4e-34 116.3 0.1 2.1e-33 114.9 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.5 AET39074.1 - 3.2e-26 91.3 0.2 6.9e-26 90.2 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 AET39074.1 - 6.8e-25 87.1 0.1 1.8e-24 85.7 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle Mog1 PF04603.12 AET39075.1 - 1.4e-38 132.4 0.1 1.7e-38 132.1 0.1 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein Gly_transf_sug PF04488.15 AET39076.1 - 4.9e-12 46.3 0.2 2.7e-11 43.9 0.1 2.2 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif Pinin_SDK_memA PF04696.13 AET39076.1 - 0.006 16.7 7.1 0.0096 16.0 7.1 1.3 1 0 0 1 1 1 1 pinin/SDK/memA/ protein conserved region TMEM192 PF14802.6 AET39076.1 - 0.034 13.2 1.8 0.052 12.6 1.8 1.2 1 0 0 1 1 1 0 TMEM192 family TMCO5 PF14992.6 AET39076.1 - 0.1 12.2 4.4 0.17 11.4 4.4 1.3 1 0 0 1 1 1 0 TMCO5 family KxDL PF10241.9 AET39076.1 - 0.14 12.5 2.0 0.31 11.4 2.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein IMD PF08397.11 AET39076.1 - 0.17 11.2 2.6 0.27 10.6 2.6 1.2 1 0 0 1 1 1 0 IRSp53/MIM homology domain Fib_alpha PF08702.10 AET39076.1 - 0.28 11.4 1.3 0.52 10.5 1.3 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Septin PF00735.18 AET39077.1 - 6.8e-108 360.2 0.0 6.8e-108 360.2 0.0 1.6 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 AET39077.1 - 6.1e-07 29.5 0.0 1.4e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 AET39077.1 - 2.6e-05 24.4 9.5 0.0045 17.1 0.2 3.0 2 1 1 3 3 3 2 Dynamin family ABC_tran PF00005.27 AET39077.1 - 0.00022 21.8 1.4 0.00037 21.0 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AIG1 PF04548.16 AET39077.1 - 0.00027 20.4 0.1 0.00027 20.4 0.1 2.1 2 0 0 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 AET39077.1 - 0.00066 19.6 1.6 0.00066 19.6 1.6 2.8 3 1 0 3 3 3 1 RsgA GTPase IIGP PF05049.13 AET39077.1 - 0.0018 17.4 0.1 0.0041 16.2 0.1 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Macoilin PF09726.9 AET39077.1 - 0.029 12.9 5.8 0.039 12.5 5.8 1.1 1 0 0 1 1 1 0 Macoilin family AAA_22 PF13401.6 AET39077.1 - 0.032 14.5 0.2 0.083 13.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 AET39077.1 - 0.059 12.9 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 AET39077.1 - 0.065 13.4 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 AET39077.1 - 0.077 12.1 4.3 0.11 11.6 0.1 2.9 4 0 0 4 4 4 0 G-protein alpha subunit AAA_29 PF13555.6 AET39077.1 - 0.082 12.7 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain PduV-EutP PF10662.9 AET39077.1 - 0.2 11.4 0.3 5.1 6.8 0.1 2.4 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.6 AET39077.1 - 0.33 11.4 10.8 1.5 9.2 6.2 2.5 2 1 0 2 2 2 0 AAA domain IGPS PF00218.21 AET39078.1 - 6.3e-87 290.9 0.0 8.2e-87 290.6 0.0 1.1 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase GATase PF00117.28 AET39078.1 - 1.2e-47 162.2 0.0 1.7e-47 161.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AET39078.1 - 3.1e-05 23.8 0.9 0.00012 21.9 0.9 1.9 1 1 0 1 1 1 1 Peptidase C26 QRPTase_C PF01729.19 AET39078.1 - 0.039 13.7 0.1 0.11 12.3 0.1 1.8 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain Peripla_BP_2 PF01497.18 AET39078.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Periplasmic binding protein Syja_N PF02383.18 AET39079.1 - 2.7e-81 273.4 1.8 3.7e-81 272.9 1.8 1.2 1 0 0 1 1 1 1 SacI homology domain DUF4314 PF14192.6 AET39079.1 - 0.14 12.0 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4314) PFU PF09070.11 AET39080.1 - 4.4e-40 136.5 0.1 1e-39 135.3 0.1 1.6 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) PUL PF08324.11 AET39080.1 - 2e-33 115.8 0.1 2.8e-33 115.3 0.1 1.2 1 0 0 1 1 1 1 PUL domain WD40 PF00400.32 AET39080.1 - 4.2e-33 112.8 12.2 1.7e-08 35.0 0.0 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat BBS2_Mid PF14783.6 AET39080.1 - 0.0017 18.3 0.2 3.8 7.6 0.0 3.5 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region FoP_duplication PF13865.6 AET39081.1 - 1.6e-07 31.7 2.8 2.7e-07 31.0 2.8 1.4 1 0 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 RRM_1 PF00076.22 AET39081.1 - 0.019 14.8 0.0 0.028 14.3 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mito_carr PF00153.27 AET39082.1 - 4.9e-47 157.8 6.4 4.9e-19 68.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein NMT1 PF09084.11 AET39083.1 - 1.8e-77 260.1 0.0 2.2e-77 259.8 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 AET39083.1 - 0.0049 16.6 0.0 0.25 11.0 0.0 2.1 2 0 0 2 2 2 1 NMT1-like family MHB PF16525.5 AET39083.1 - 0.046 14.0 0.1 0.14 12.4 0.0 1.8 2 0 0 2 2 2 0 Haemophore, haem-binding PBP_like PF12727.7 AET39083.1 - 0.049 12.7 0.0 0.12 11.5 0.0 1.6 1 1 0 1 1 1 0 PBP superfamily domain Arm-DNA-bind_4 PF14657.6 AET39084.1 - 0.075 12.8 1.5 0.14 12.0 0.4 1.9 2 0 0 2 2 2 0 Arm DNA-binding domain RTA1 PF04479.13 AET39085.1 - 1.3e-59 201.3 17.3 1.3e-59 201.3 17.3 1.7 2 0 0 2 2 2 1 RTA1 like protein Caveolin PF01146.17 AET39085.1 - 0.19 11.7 0.2 0.19 11.7 0.2 2.4 3 0 0 3 3 3 0 Caveolin Thiolase_N PF00108.23 AET39087.1 - 4.5e-84 281.9 0.4 6.5e-84 281.3 0.4 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 AET39087.1 - 1.5e-46 157.0 0.5 2.7e-46 156.2 0.5 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 AET39087.1 - 0.00017 21.2 3.2 0.00017 21.2 0.8 2.1 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 AET39087.1 - 0.48 10.3 5.7 4.9 7.1 0.2 2.9 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III FH2 PF02181.23 AET39088.1 - 2.4e-70 237.5 8.4 2.4e-70 237.5 8.4 2.3 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 AET39088.1 - 3.1e-07 30.2 0.0 3.1e-07 30.2 0.0 3.0 3 0 0 3 3 3 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 AET39088.1 - 3.7e-05 23.4 1.3 3.7e-05 23.4 1.3 4.3 4 1 0 4 4 4 1 Diaphanous FH3 Domain ssDNA_DBD PF18333.1 AET39088.1 - 0.17 12.0 5.2 0.099 12.7 0.3 2.9 2 0 0 2 2 2 0 Non-canonical single-stranded DNA-binding domain CHDCT2 PF08074.11 AET39088.1 - 3.1 8.0 7.6 17 5.6 1.5 2.8 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain Adhesin_P1 PF03257.13 AET39089.1 - 0.02 15.4 1.5 0.06 13.9 1.5 1.8 1 0 0 1 1 1 0 Mycoplasma adhesin P1 Coa1 PF08695.10 AET39090.1 - 1.8e-36 124.5 0.1 2.2e-36 124.1 0.1 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 DUF1748 PF08520.10 AET39091.1 - 1.4e-28 98.6 0.1 1.5e-28 98.5 0.1 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Myb_DNA-bind_6 PF13921.6 AET39092.1 - 2.7e-29 101.2 1.4 3.3e-11 43.3 0.1 3.7 2 1 1 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 AET39092.1 - 1.5e-28 98.7 9.2 1.4e-11 44.4 0.4 3.5 3 0 0 3 3 3 3 Myb-like DNA-binding domain SLIDE PF09111.10 AET39092.1 - 6.8e-05 22.9 0.6 1.2 9.2 0.0 3.8 2 1 2 4 4 4 2 SLIDE Rap1_C PF11626.8 AET39092.1 - 1.9 8.7 5.6 17 5.6 1.7 3.4 1 1 1 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain UCH PF00443.29 AET39093.1 - 3.1e-56 190.7 5.2 6.6e-56 189.6 5.2 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AET39093.1 - 5.1e-17 62.4 4.8 5.1e-17 62.4 4.8 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 AET39093.1 - 0.0025 18.3 0.0 0.0068 16.9 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain DAO PF01266.24 AET39094.1 - 2.8e-48 165.3 0.0 4.3e-48 164.7 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 AET39094.1 - 4.1e-40 136.6 0.0 8.1e-40 135.6 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 AET39094.1 - 9.7e-13 48.0 1.9 4.5e-12 45.8 1.9 1.8 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 AET39094.1 - 1.2e-08 34.8 0.2 1.1e-05 25.0 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.22 AET39094.1 - 3.8e-06 26.2 0.3 0.001 18.2 0.1 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 AET39094.1 - 9.3e-06 25.1 0.1 0.00015 21.1 0.1 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 AET39094.1 - 0.00031 20.1 0.1 0.054 12.7 0.0 2.4 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 AET39094.1 - 0.00075 18.3 0.2 0.0012 17.6 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 AET39094.1 - 0.00089 18.6 0.1 1.2 8.3 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 AET39094.1 - 0.001 19.2 0.3 0.0027 17.9 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 AET39094.1 - 0.019 14.3 0.0 0.095 11.9 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 AET39094.1 - 0.02 14.2 0.0 0.058 12.7 0.0 1.8 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 AET39094.1 - 0.069 13.0 0.9 0.29 11.0 0.4 2.1 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_34 PF11312.8 AET39094.1 - 0.14 11.4 0.1 0.72 9.0 0.0 2.1 3 0 0 3 3 3 0 Putative SAM-dependent methyltransferase PTPA PF03095.15 AET39096.1 - 5.1e-98 328.3 0.0 5.8e-98 328.1 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein PEPCK_ATP PF01293.20 AET39097.1 - 8.5e-216 717.1 0.0 1e-215 716.8 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase DUF4914 PF16260.5 AET39097.1 - 0.0012 17.1 0.0 0.0055 14.9 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4914) AAA_33 PF13671.6 AET39097.1 - 0.015 15.4 0.0 0.071 13.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 AET39097.1 - 0.074 12.4 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 KaiC AAA_29 PF13555.6 AET39097.1 - 0.12 12.2 0.1 0.31 10.8 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.6 AET39097.1 - 0.17 11.5 0.1 0.33 10.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain Pirin_C_2 PF17954.1 AET39098.1 - 0.12 12.6 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 Quercetinase C-terminal cupin domain PIN_4 PF13638.6 AET39099.1 - 4.9e-14 52.7 0.1 1.6e-13 51.1 0.1 1.9 1 0 0 1 1 1 1 PIN domain Menin PF05053.13 AET39099.1 - 2 6.6 7.6 4.1 5.7 7.6 1.4 1 0 0 1 1 1 0 Menin NPR3 PF03666.13 AET39099.1 - 2.9 6.6 9.8 6.2 5.5 9.8 1.5 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Pcc1 PF09341.10 AET39100.1 - 2.3e-17 62.9 0.0 4.1e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 Transcription factor Pcc1 DUF1582 PF07621.11 AET39100.1 - 0.16 11.9 0.6 2 8.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1582) TPR_MLP1_2 PF07926.12 AET39101.1 - 1.4e-31 109.2 27.6 1.4e-31 109.2 27.6 16.7 6 4 9 16 16 16 6 TPR/MLP1/MLP2-like protein DUF2477 PF10631.9 AET39101.1 - 8.5 7.0 5.5 16 6.1 0.1 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2477) ubiquitin PF00240.23 AET39102.1 - 1.5e-34 117.6 0.5 1.9e-34 117.2 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 AET39102.1 - 5.6e-31 106.2 10.9 8.5e-31 105.6 10.9 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 AET39102.1 - 3.2e-16 58.9 0.6 4.5e-16 58.4 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 AET39102.1 - 2.1e-05 24.9 0.1 7.7e-05 23.1 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 AET39102.1 - 0.0048 16.8 0.0 0.0063 16.4 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 AET39102.1 - 0.0048 17.0 0.1 0.0096 16.0 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 AET39102.1 - 0.0057 17.0 0.0 0.0084 16.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 AET39102.1 - 0.014 15.4 1.1 4 7.5 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 AET39102.1 - 0.026 15.1 0.0 0.032 14.8 0.0 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Response_reg PF00072.24 AET39103.1 - 9.1e-28 96.7 0.3 1.9e-27 95.7 0.3 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 AET39103.1 - 1.3e-26 93.3 1.4 6.9e-20 71.6 0.1 2.5 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 AET39103.1 - 5.9e-13 48.7 0.3 1.8e-12 47.1 0.3 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 AET39103.1 - 0.00011 22.5 0.5 0.15 12.5 0.0 2.7 2 0 0 2 2 2 2 HAMP domain TFIIE-A_C PF11521.8 AET39104.1 - 0.059 13.7 0.6 0.14 12.4 0.6 1.7 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha RE_HaeII PF09554.10 AET39104.1 - 0.082 12.1 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 HaeII restriction endonuclease DMAP_binding PF06464.11 AET39104.1 - 0.085 13.7 0.3 0.18 12.6 0.3 1.5 1 0 0 1 1 1 0 DMAP1-binding Domain DUF1910 PF08928.10 AET39104.1 - 0.14 12.2 0.1 8.5 6.4 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1910) EKLF_TAD1 PF16832.5 AET39104.1 - 3.8 7.5 7.7 0.21 11.5 2.3 1.8 2 0 0 2 2 2 0 Erythroid krueppel-like transcription factor, transactivation 1 MFA1_2 PF17317.2 AET39105.1 - 4.4e-21 74.3 3.1 4.7e-21 74.3 3.1 1.0 1 0 0 1 1 1 1 Mating hormone A-factor 1&2 Malate_DH PF12434.8 AET39105.1 - 0.15 12.1 1.9 0.19 11.8 1.9 1.2 1 0 0 1 1 1 0 Malate dehydrogenase enzyme Pantoate_ligase PF02569.15 AET39106.1 - 9.6e-90 300.4 0.0 1.1e-89 300.2 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase CTP_transf_like PF01467.26 AET39106.1 - 0.024 14.8 0.0 0.042 14.0 0.0 1.4 1 0 0 1 1 1 0 Cytidylyltransferase-like FAD_syn PF06574.12 AET39106.1 - 0.19 11.6 0.0 0.32 10.9 0.0 1.3 1 0 0 1 1 1 0 FAD synthetase Ndc80_HEC PF03801.13 AET39107.1 - 7.2e-51 171.8 0.2 7.2e-51 171.8 0.2 2.2 3 0 0 3 3 3 1 HEC/Ndc80p family DUF5595 PF18077.1 AET39107.1 - 2e-24 85.4 3.5 2e-24 85.4 3.5 4.4 3 1 0 4 4 4 1 Domain of unknown function (DUF5595) Spc7 PF08317.11 AET39107.1 - 0.0025 16.7 40.4 0.0083 15.0 18.0 3.0 3 0 0 3 3 3 2 Spc7 kinetochore protein MPS2 PF17060.5 AET39107.1 - 0.0028 17.0 10.7 0.0028 17.0 10.7 2.9 2 1 1 3 3 3 1 Monopolar spindle protein 2 Cluap1 PF10234.9 AET39107.1 - 0.15 11.4 35.1 0.11 11.9 11.6 3.9 3 1 1 4 4 4 0 Clusterin-associated protein-1 OmpH PF03938.14 AET39107.1 - 0.22 11.9 26.2 1.6 9.0 13.0 2.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) FIVAR PF07554.13 AET39107.1 - 0.27 12.0 8.0 0.55 11.0 0.9 3.6 2 1 0 2 2 2 0 FIVAR domain Glyco_transf_28 PF03033.20 AET39107.1 - 1.8 8.6 3.5 12 5.9 0.0 3.1 2 1 1 3 3 3 0 Glycosyltransferase family 28 N-terminal domain TPR_MLP1_2 PF07926.12 AET39107.1 - 8.3 6.5 42.8 0.85 9.7 19.1 3.6 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein ERCC3_RAD25_C PF16203.5 AET39108.1 - 3.4e-125 416.2 1.0 5.6e-125 415.5 1.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 AET39108.1 - 1.2e-35 122.5 0.0 2.7e-35 121.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET39108.1 - 1.6e-15 57.6 0.0 3e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 AET39108.1 - 3.6e-12 46.6 0.1 8.8e-12 45.4 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 AET39108.1 - 8.8e-09 34.5 0.0 1.1e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 AET39108.1 - 0.00038 20.3 0.0 0.00072 19.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SBP_bac_6 PF13343.6 AET39108.1 - 0.015 14.7 0.0 0.039 13.4 0.0 1.6 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein Cas_Csm6 PF09659.10 AET39108.1 - 0.094 11.5 1.1 2.3 6.9 0.6 2.2 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csm6) SRP40_C PF05022.12 AET39109.1 - 1.5e-24 86.6 4.5 5.1e-24 84.9 4.5 2.0 1 0 0 1 1 1 1 SRP40, C-terminal domain LAP1C PF05609.12 AET39109.1 - 0.25 10.4 35.8 0.36 9.9 35.8 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Abhydrolase_6 PF12697.7 AET39110.1 - 1.2e-14 55.5 0.0 1.5e-14 55.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AET39110.1 - 4.3e-09 36.0 0.0 6.9e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AET39110.1 - 1.1e-07 31.8 0.0 3.2e-07 30.3 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 AET39110.1 - 3.5e-06 26.9 0.0 5.7e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 AET39110.1 - 0.037 13.5 0.1 0.1 12.0 0.1 1.8 2 1 0 2 2 2 0 Prolyl oligopeptidase family DUF4572 PF15139.6 AET39110.1 - 0.059 13.3 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4572) Lipase_3 PF01764.25 AET39110.1 - 0.22 11.4 0.9 5.9 6.8 0.2 2.5 1 1 1 2 2 2 0 Lipase (class 3) LIM PF00412.22 AET39111.1 - 8.2e-16 58.0 25.7 3.6e-09 36.7 8.6 2.3 2 0 0 2 2 2 2 LIM domain DUF3336 PF11815.8 AET39112.1 - 2e-33 115.0 5.8 4.9e-33 113.8 5.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 AET39112.1 - 8.3e-25 88.2 0.0 1.4e-24 87.4 0.0 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase F-box PF00646.33 AET39113.1 - 1.9e-05 24.4 2.5 6.8e-05 22.6 2.5 2.0 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 AET39113.1 - 0.00052 19.9 1.2 0.00052 19.9 1.2 2.4 3 0 0 3 3 3 1 F-box-like LRR_1 PF00560.33 AET39113.1 - 0.0077 16.6 5.0 3.4 8.6 0.2 5.0 3 1 0 3 3 3 1 Leucine Rich Repeat TPR_2 PF07719.17 AET39113.1 - 0.0096 16.0 11.2 0.12 12.5 0.5 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 AET39113.1 - 0.047 13.5 0.2 0.047 13.5 0.2 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 AET39113.1 - 0.075 13.3 0.3 1.4 9.2 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat LRR_4 PF12799.7 AET39113.1 - 0.1 13.0 14.0 5.9 7.5 0.5 5.5 2 2 3 5 5 5 0 Leucine Rich repeats (2 copies) TPR_7 PF13176.6 AET39113.1 - 0.6 10.3 2.3 1.4 9.1 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat U3_snoRNA_assoc PF08297.11 AET39114.1 - 3.3e-18 66.2 5.6 3.3e-18 66.2 5.6 3.0 2 1 0 2 2 2 1 U3 snoRNA associated SNARE_assoc PF09335.11 AET39116.1 - 1.1e-13 51.7 7.7 1.1e-13 51.7 7.7 2.5 3 1 0 3 3 3 1 SNARE associated Golgi protein SeqA_N PF17206.3 AET39116.1 - 0.14 11.5 0.0 0.29 10.5 0.0 1.5 1 0 0 1 1 1 0 SeqA protein N-terminal domain DUF4191 PF13829.6 AET39116.1 - 0.16 11.3 2.6 0.098 12.0 0.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) Kin17_mid PF10357.9 AET39117.1 - 3e-43 146.8 7.0 4.4e-43 146.2 7.0 1.3 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.8 AET39117.1 - 7.6e-06 26.1 3.0 7.6e-06 26.1 3.0 1.9 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 AET39117.1 - 4.2e-05 23.8 2.9 0.0001 22.5 2.9 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 AET39117.1 - 0.0032 17.8 1.2 0.0032 17.8 1.2 2.5 1 1 0 2 2 2 1 C2H2 type zinc-finger (2 copies) TFIID_NTD2 PF04494.15 AET39117.1 - 0.0069 16.6 0.8 0.014 15.6 0.8 1.6 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain RNA_pol_Rpb2_6 PF00562.28 AET39117.1 - 0.022 13.8 1.1 0.028 13.5 1.1 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 6 Prenyltrans PF00432.21 AET39117.1 - 0.05 13.4 0.0 2.4 8.0 0.0 2.4 2 0 0 2 2 2 0 Prenyltransferase and squalene oxidase repeat RL PF17797.1 AET39117.1 - 0.088 12.8 0.2 0.25 11.3 0.1 1.8 1 1 0 1 1 1 0 RL domain Mersacidin PF16934.5 AET39117.1 - 0.18 11.6 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 Two-component Enterococcus faecalis cytolysin (EFC) AKAP95 PF04988.12 AET39117.1 - 0.68 10.1 9.5 0.18 12.0 5.7 1.9 2 0 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) Peptidase_M48 PF01435.18 AET39118.1 - 7.3e-31 107.5 0.0 1.2e-30 106.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M48 PriCT_2 PF08707.11 AET39118.1 - 0.037 14.4 0.2 3.1 8.2 0.0 2.4 2 0 0 2 2 2 0 Primase C terminal 2 (PriCT-2) HA2 PF04408.23 AET39119.1 - 1.9e-19 69.9 0.4 2.4e-18 66.4 0.0 2.9 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 AET39119.1 - 9.4e-18 64.4 0.0 2.7e-17 62.9 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 AET39119.1 - 8.2e-16 58.3 0.4 2.9e-15 56.6 0.0 2.1 2 0 0 2 2 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 AET39119.1 - 1.7e-06 27.9 0.1 3.9e-06 26.7 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AET39119.1 - 1.7e-05 25.1 0.3 7.8e-05 23.0 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 AET39119.1 - 0.0067 16.8 0.5 0.039 14.3 0.0 2.4 3 0 0 3 3 3 1 AAA domain Peptidase_M17_N PF02789.17 AET39119.1 - 0.0078 16.1 0.1 0.02 14.7 0.1 1.7 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain DUF2075 PF09848.9 AET39119.1 - 0.011 15.0 0.0 0.021 14.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Flavi_DEAD PF07652.14 AET39119.1 - 0.012 15.6 0.0 0.022 14.8 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_30 PF13604.6 AET39119.1 - 0.016 14.9 0.0 0.034 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 AET39119.1 - 0.046 12.8 0.1 0.11 11.5 0.1 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.16 AET39119.1 - 0.051 13.0 0.4 0.21 11.0 0.0 2.2 3 0 0 3 3 3 0 PhoH-like protein ATPase PF06745.13 AET39119.1 - 0.062 12.6 0.6 0.17 11.2 0.0 2.0 2 0 0 2 2 2 0 KaiC RsgA_GTPase PF03193.16 AET39119.1 - 0.063 13.2 0.6 0.13 12.2 0.1 1.7 2 0 0 2 2 1 0 RsgA GTPase AAA_23 PF13476.6 AET39119.1 - 0.097 13.2 0.4 0.097 13.2 0.4 4.1 3 2 0 3 3 3 0 AAA domain ABC_tran PF00005.27 AET39119.1 - 0.11 13.1 0.0 0.63 10.5 0.0 2.4 2 0 0 2 2 1 0 ABC transporter AAA_29 PF13555.6 AET39119.1 - 0.13 12.0 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.6 AET39119.1 - 2.7 8.1 6.6 3.8 7.5 0.8 3.2 2 1 0 2 2 2 0 AAA domain MRP-L20 PF12824.7 AET39120.1 - 1.5e-48 165.1 3.9 1.7e-48 164.9 3.9 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Syntaxin-18_N PF10496.9 AET39122.1 - 8.3e-15 54.8 2.4 1.1e-14 54.4 0.0 2.3 2 1 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 AET39122.1 - 0.00021 21.2 0.3 0.0013 18.6 0.1 2.2 2 0 0 2 2 2 1 SNARE domain NinG PF05766.12 AET39122.1 - 0.034 14.1 2.0 0.63 10.0 0.1 2.4 2 0 0 2 2 2 0 Bacteriophage Lambda NinG protein DUF919 PF06034.11 AET39122.1 - 0.4 10.5 10.8 1.8 8.5 2.1 3.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) TipAS PF07739.13 AET39122.1 - 1 10.0 6.0 0.78 10.3 2.7 2.2 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain Nop PF01798.18 AET39122.1 - 1.6 8.2 10.4 0.19 11.2 4.4 2.1 2 1 0 2 2 2 0 snoRNA binding domain, fibrillarin RecG_N PF17190.4 AET39122.1 - 4.1 8.2 20.0 2.3 9.0 5.7 2.9 2 2 0 2 2 2 0 RecG N-terminal helical domain DUF948 PF06103.11 AET39122.1 - 7.4 6.9 12.1 3.4 8.0 5.6 2.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Thymidylat_synt PF00303.19 AET39123.1 - 4e-114 380.3 0.0 4.5e-114 380.1 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase Shugoshin_N PF07558.11 AET39124.1 - 3.6e-17 62.0 4.7 1.1e-16 60.4 4.7 2.0 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.11 AET39124.1 - 2.3e-11 43.3 4.3 5.9e-11 42.0 4.3 1.8 1 0 0 1 1 1 1 Shugoshin C terminus TSC22 PF01166.18 AET39124.1 - 0.01 16.2 0.8 0.074 13.4 0.3 2.9 1 1 1 2 2 2 0 TSC-22/dip/bun family DASH_Dad2 PF08654.10 AET39125.1 - 2.1e-31 108.2 0.7 2.4e-31 108.1 0.7 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad2 Rogdi_lz PF10259.9 AET39125.1 - 0.0034 16.9 0.3 0.0039 16.7 0.3 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein DASH_Duo1 PF08651.10 AET39125.1 - 0.033 13.9 1.2 0.049 13.4 1.2 1.2 1 0 0 1 1 1 0 DASH complex subunit Duo1 Lipoprotein_2 PF00921.17 AET39125.1 - 0.063 12.8 0.0 0.076 12.6 0.0 1.0 1 0 0 1 1 1 0 Borrelia lipoprotein FAP206 PF12018.8 AET39125.1 - 0.064 12.7 1.5 0.1 12.1 1.0 1.5 1 1 1 2 2 2 0 Domain of unknown function Nucleoporin_N PF08801.11 AET39126.1 - 1.4e-65 221.8 1.0 2.6e-65 220.9 1.0 1.5 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 AET39126.1 - 1.6e-38 132.9 4.0 3e-38 131.9 4.0 1.3 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Brix PF04427.18 AET39127.1 - 2.5e-37 128.8 0.2 3.4e-37 128.4 0.2 1.2 1 0 0 1 1 1 1 Brix domain THF_DHG_CYH PF00763.23 AET39128.1 - 5.1e-25 88.0 0.0 1e-24 87.0 0.0 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 AET39128.1 - 1.9e-17 63.0 0.0 4.8e-11 42.2 0.0 2.6 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain FTP PF07504.13 AET39128.1 - 0.038 13.8 1.1 0.082 12.8 1.1 1.6 1 0 0 1 1 1 0 Fungalysin/Thermolysin Propeptide Motif RabGAP-TBC PF00566.18 AET39129.1 - 1.7e-52 178.2 2.0 3.6e-52 177.1 2.0 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Lactamase_B_4 PF13691.6 AET39130.1 - 6e-25 86.7 0.0 1.3e-24 85.6 0.0 1.6 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 AET39130.1 - 2.7e-08 33.6 0.0 0.0066 16.0 0.0 2.7 3 0 0 3 3 3 2 Beta-lactamase superfamily domain Vps5 PF09325.10 AET39131.1 - 1.5e-78 263.6 11.2 1.5e-78 263.6 11.2 1.7 2 0 0 2 2 2 1 Vps5 C terminal like PX PF00787.24 AET39131.1 - 7.3e-25 87.2 1.0 7.3e-25 87.2 1.0 2.3 2 0 0 2 2 2 1 PX domain DUF1664 PF07889.12 AET39131.1 - 0.23 11.5 12.5 0.28 11.2 1.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Alg6_Alg8 PF03155.15 AET39132.1 - 3.1e-160 534.3 38.5 3.6e-160 534.1 38.5 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family HTH_53 PF18606.1 AET39133.1 - 0.21 11.3 0.0 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 Zap helix turn helix N-terminal domain Cytochrom_C1 PF02167.15 AET39134.1 - 1.6e-95 319.0 0.0 2e-95 318.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 AET39134.1 - 0.00077 19.7 0.0 0.0016 18.7 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 AET39134.1 - 0.0018 19.4 0.1 0.0042 18.2 0.1 1.9 1 1 0 1 1 1 1 Cytochrome c CREPT PF16566.5 AET39135.1 - 0.0085 16.3 0.6 0.014 15.6 0.6 1.3 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour zf-HC5HC2H PF13771.6 AET39135.1 - 0.013 15.7 1.8 0.013 15.7 1.8 1.8 2 1 0 2 2 2 0 PHD-like zinc-binding domain Sec8_exocyst PF04048.14 AET39135.1 - 0.024 14.5 0.3 0.042 13.7 0.3 1.3 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain HAUS6_N PF14661.6 AET39135.1 - 0.17 11.4 3.4 0.24 11.0 3.4 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus REV1_C PF16727.5 AET39135.1 - 0.5 10.8 4.1 1.1 9.7 4.1 1.5 1 1 0 1 1 1 0 DNA repair protein REV1 C-terminal domain Ribosomal_L3 PF00297.22 AET39136.1 - 2e-191 635.8 11.2 2.2e-191 635.7 11.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 Pkinase PF00069.25 AET39137.1 - 9.4e-57 192.4 0.0 1.1e-56 192.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET39137.1 - 4.3e-15 55.7 0.0 6.1e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 AET39137.1 - 4.1e-07 30.2 0.1 1e-06 28.9 0.1 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 AET39137.1 - 0.019 14.6 0.0 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 AET39137.1 - 0.044 12.6 0.0 0.064 12.0 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 AET39137.1 - 0.097 12.0 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sld7_N PF18636.1 AET39138.1 - 8.3e-34 116.6 0.0 1.8e-33 115.5 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial morphogenesis protein SLD7 N-terminal domain Sld7_C PF18596.1 AET39138.1 - 1.5e-18 66.7 0.1 3.3e-18 65.6 0.1 1.6 1 0 0 1 1 1 1 Sld7 C-terminal domain Med3 PF11593.8 AET39138.1 - 0.94 8.6 18.9 1.3 8.2 18.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF676 PF05057.14 AET39139.1 - 2.9e-48 164.3 0.1 4.4e-48 163.7 0.1 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 AET39139.1 - 0.0016 18.2 0.0 0.0032 17.2 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Lipase_2 PF01674.18 AET39139.1 - 0.013 15.0 0.0 0.026 14.0 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 2) Palm_thioest PF02089.15 AET39139.1 - 0.052 13.4 0.0 0.089 12.6 0.0 1.5 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Sugar_tr PF00083.24 AET39142.1 - 2e-30 106.0 24.4 7.4e-20 71.2 7.0 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 AET39142.1 - 2.1e-19 69.7 41.5 1.1e-11 44.3 17.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sterol_MT_C PF08498.10 AET39143.1 - 3.4e-25 88.1 1.3 6.9e-25 87.2 1.3 1.5 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 AET39143.1 - 3.4e-18 66.1 0.0 6.9e-18 65.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AET39143.1 - 1.4e-15 57.7 0.0 2.9e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AET39143.1 - 1.5e-11 44.3 0.0 2.2e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AET39143.1 - 5.8e-10 38.9 0.0 8.7e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 AET39143.1 - 1.5e-09 37.9 0.0 2.3e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 AET39143.1 - 3.2e-09 36.5 0.1 4.7e-09 35.9 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 AET39143.1 - 1.3e-06 29.1 0.0 3.7e-06 27.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 AET39143.1 - 0.00036 20.1 0.1 0.00058 19.5 0.1 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase RrnaAD PF00398.20 AET39143.1 - 0.054 12.5 0.0 0.093 11.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase bZIP_1 PF00170.21 AET39144.1 - 6.7e-07 29.3 16.8 1.7e-06 28.0 16.8 1.7 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 AET39144.1 - 0.077 13.1 22.2 0.48 10.5 21.3 2.4 1 1 0 1 1 1 0 Basic region leucine zipper Frigida PF07899.11 AET39144.1 - 0.31 10.2 3.4 0.52 9.5 3.4 1.3 1 0 0 1 1 1 0 Frigida-like protein bZIP_Maf PF03131.17 AET39144.1 - 0.84 10.2 22.3 0.1 13.2 14.8 2.4 2 0 0 2 2 2 0 bZIP Maf transcription factor AMPKBI PF04739.15 AET39145.1 - 6e-20 71.3 0.2 2.1e-19 69.6 0.2 1.9 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM PF16561.5 AET39145.1 - 5e-08 33.1 0.0 1.6e-07 31.4 0.0 1.9 2 0 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase ANAPC_CDC26 PF10471.9 AET39145.1 - 5.6 7.9 13.1 2.5 9.0 0.6 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Kinesin PF00225.23 AET39146.1 - 1.4e-100 336.4 3.7 1.4e-100 336.4 3.7 1.5 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 AET39146.1 - 1.6e-26 93.1 1.0 1.6e-26 93.1 1.0 2.5 2 1 0 2 2 2 1 Microtubule binding EzrA PF06160.12 AET39146.1 - 0.0028 15.9 8.7 0.0031 15.8 7.6 1.6 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA Med22 PF06179.12 AET39146.1 - 0.0055 16.9 2.1 0.2 11.9 1.7 3.0 3 0 0 3 3 3 1 Surfeit locus protein 5 subunit 22 of Mediator complex DUF3686 PF12458.8 AET39146.1 - 0.017 13.7 0.2 0.031 12.8 0.2 1.3 1 0 0 1 1 1 0 ATPase involved in DNA repair DUF5420 PF17457.2 AET39146.1 - 0.06 13.2 0.6 0.34 10.8 0.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5420) IpaB_EvcA PF03278.13 AET39146.1 - 0.065 12.9 1.8 0.85 9.3 0.2 2.7 2 0 0 2 2 2 0 IpaB/EvcA family Carbpep_Y_N PF05388.11 AET39146.1 - 0.47 11.0 5.0 0.2 12.2 2.1 1.8 2 0 0 2 2 2 0 Carboxypeptidase Y pro-peptide FlxA PF14282.6 AET39146.1 - 1.2 9.2 16.4 0.83 9.7 10.3 2.7 2 0 0 2 2 2 0 FlxA-like protein YabA PF06156.13 AET39146.1 - 4 8.1 11.5 3.5 8.3 0.1 3.6 2 1 0 3 3 3 0 Initiation control protein YabA DUF16 PF01519.16 AET39146.1 - 7.8 7.0 11.5 2.7 8.5 4.2 3.1 3 0 0 3 3 3 0 Protein of unknown function DUF16 Dynein_light PF01221.18 AET39147.1 - 3.2e-34 117.1 0.0 3.5e-34 117.0 0.0 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 PX PF00787.24 AET39148.1 - 1.8e-14 53.7 1.8 3.2e-14 52.9 0.1 2.3 3 0 0 3 3 3 1 PX domain DUF489 PF04356.12 AET39148.1 - 0.062 13.3 6.1 1.8 8.5 3.4 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF489) Helitron_like_N PF14214.6 AET39148.1 - 0.1 12.8 2.5 0.27 11.4 2.5 1.6 1 0 0 1 1 1 0 Helitron helicase-like domain at N-terminus Metal_resist PF13801.6 AET39148.1 - 0.23 11.6 5.9 6.2 7.0 6.2 2.4 2 0 0 2 2 2 0 Heavy-metal resistance YqzL PF14006.6 AET39148.1 - 0.62 10.5 5.0 0.14 12.5 0.4 2.3 2 0 0 2 2 2 0 YqzL-like protein FliJ PF02050.16 AET39148.1 - 4.2 7.6 20.2 11 6.3 11.1 3.3 3 0 0 3 3 3 0 Flagellar FliJ protein DUF2433 PF10360.9 AET39148.1 - 5.1 7.2 6.7 11 6.1 1.8 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2433) Rpn9_C PF18261.1 AET39149.1 - 1.2e-18 66.3 4.1 3.1e-18 65.0 4.1 1.8 1 0 0 1 1 1 1 Rpn9 C-terminal helix PCI PF01399.27 AET39149.1 - 6e-11 42.8 0.3 1.7e-10 41.3 0.3 1.8 1 0 0 1 1 1 1 PCI domain Glyco_transf_7N PF13733.6 AET39149.1 - 0.066 12.8 0.0 0.2 11.3 0.0 1.7 1 0 0 1 1 1 0 N-terminal region of glycosyl transferase group 7 Spo0A_C PF08769.11 AET39149.1 - 0.081 13.0 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Sporulation initiation factor Spo0A C terminal DUF2800 PF10926.8 AET39149.1 - 0.11 11.8 0.1 0.17 11.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2800) Abhydrolase_3 PF07859.13 AET39150.1 - 1e-09 38.6 0.0 1.4e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold LIDHydrolase PF10230.9 AET39150.1 - 0.0016 18.1 0.5 0.0061 16.2 0.1 1.9 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase DUF915 PF06028.11 AET39150.1 - 0.017 14.4 0.0 0.43 9.9 0.0 2.3 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_1 PF00561.20 AET39150.1 - 0.026 14.2 0.0 0.041 13.5 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 AET39150.1 - 0.048 13.5 0.0 0.092 12.6 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) Hydrolase_4 PF12146.8 AET39150.1 - 0.091 12.0 0.0 0.51 9.5 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 AET39150.1 - 0.1 13.2 0.0 0.1 13.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF900 PF05990.12 AET39150.1 - 0.11 12.0 0.1 0.23 10.9 0.1 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) eIF3g PF12353.8 AET39151.1 - 2.5e-39 134.5 0.4 4.5e-39 133.7 0.4 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 AET39151.1 - 6.4e-11 41.9 0.0 1.2e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC_2 PF13696.6 AET39151.1 - 0.00079 19.2 0.4 0.0013 18.5 0.4 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 AET39151.1 - 0.12 12.5 2.1 0.21 11.7 2.1 1.3 1 0 0 1 1 1 0 Zinc knuckle Ribosomal_L33 PF00471.20 AET39152.1 - 0.001 19.5 0.3 0.0023 18.3 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L33 Spt5-NGN PF03439.13 AET39153.1 - 5.7e-22 77.4 0.0 1.2e-21 76.4 0.0 1.6 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.8 AET39153.1 - 2.5e-20 73.3 15.3 2.5e-20 73.3 15.3 3.2 2 1 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.29 AET39153.1 - 4.2e-18 64.6 5.1 0.002 18.0 0.0 4.8 4 0 0 4 4 4 4 KOW motif CTD PF12815.7 AET39153.1 - 0.0083 16.7 29.4 0.0083 16.7 29.4 3.3 1 1 1 2 2 2 1 Spt5 C-terminal nonapeptide repeat binding Spt4 BUD22 PF09073.10 AET39153.1 - 9.5 5.4 35.4 18 4.5 35.4 1.4 1 0 0 1 1 1 0 BUD22 Rad33 PF08730.10 AET39154.1 - 6.2e-13 49.1 1.3 6.2e-06 26.3 0.2 2.1 1 1 1 2 2 2 2 Rad33 EMP24_GP25L PF01105.24 AET39155.1 - 6.6e-39 133.7 0.8 8.1e-39 133.4 0.8 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Spc24 PF08286.11 AET39155.1 - 0.033 14.4 0.1 0.36 11.1 0.1 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF2418 PF10332.9 AET39155.1 - 0.078 13.5 0.4 0.27 11.8 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2418) DUF4164 PF13747.6 AET39155.1 - 0.2 12.0 3.3 0.33 11.3 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) M16C_assoc PF08367.11 AET39156.1 - 1.4e-71 240.6 0.6 2.1e-71 240.0 0.6 1.3 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 AET39156.1 - 1.5e-23 83.8 0.0 5.4e-16 59.1 0.0 2.8 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 AET39156.1 - 8.6e-07 29.0 0.0 4.6e-06 26.7 0.0 2.2 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) RRM_1 PF00076.22 AET39157.1 - 4.5e-28 96.9 0.5 3.4e-16 58.8 0.2 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AET39157.1 - 0.00079 19.0 0.0 0.0015 18.2 0.0 1.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 AET39157.1 - 0.048 13.7 0.0 3.4 7.8 0.0 2.3 2 0 0 2 2 2 0 Limkain b1 RRM_9 PF18444.1 AET39157.1 - 0.057 13.3 0.0 3.8 7.4 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif RNA_bind PF08675.11 AET39157.1 - 0.063 13.3 0.0 0.098 12.7 0.0 1.3 1 0 0 1 1 1 0 RNA binding domain RRM_7 PF16367.5 AET39157.1 - 0.064 13.4 0.0 0.43 10.7 0.0 2.0 1 1 1 2 2 2 0 RNA recognition motif DbpA PF03880.15 AET39157.1 - 0.073 13.1 0.0 6.1 6.9 0.0 2.2 2 0 0 2 2 2 0 DbpA RNA binding domain UBA_4 PF14555.6 AET39158.1 - 1.5e-11 43.9 0.0 3.5e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 AET39158.1 - 2.9e-11 43.4 0.0 3.5e-09 36.8 0.0 3.1 2 1 0 2 2 2 1 UBX domain AAA_15 PF13175.6 AET39158.1 - 0.014 15.1 7.4 0.024 14.4 7.4 1.4 1 0 0 1 1 1 0 AAA ATPase domain MDM10 PF12519.8 AET39158.1 - 0.06 12.2 3.0 0.093 11.6 3.0 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Rsa3 PF14615.6 AET39158.1 - 0.11 12.0 0.1 1.4 8.5 0.0 2.6 2 0 0 2 2 2 0 Ribosome-assembly protein 3 PIG-S PF10510.9 AET39159.1 - 5.1e-128 428.1 7.8 5.9e-128 427.9 7.8 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein TAFII28 PF04719.14 AET39160.1 - 3.1e-27 94.5 0.4 1.7e-22 79.3 0.1 2.7 2 0 0 2 2 2 2 hTAFII28-like protein conserved region MCM6_C PF18263.1 AET39160.1 - 0.0095 16.2 0.9 0.0095 16.2 0.9 3.2 4 0 0 4 4 4 1 MCM6 C-terminal winged-helix domain PBP1_TM PF14812.6 AET39160.1 - 7.3 7.0 8.6 0.92 9.9 0.2 2.6 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal LCM PF04072.14 AET39161.1 - 4.2e-21 75.7 0.0 6.4e-21 75.2 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Metallophos PF00149.28 AET39162.1 - 2.4e-36 126.2 0.1 5.2e-36 125.1 0.1 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 AET39162.1 - 5.5e-19 68.3 0.2 1.2e-18 67.3 0.2 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain PIG-P PF08510.12 AET39163.1 - 4.5e-34 117.0 1.3 5.2e-34 116.8 1.3 1.0 1 0 0 1 1 1 1 PIG-P MFS_1 PF07690.16 AET39163.1 - 0.022 13.7 0.5 0.027 13.4 0.5 1.0 1 0 0 1 1 1 0 Major Facilitator Superfamily DUF485 PF04341.12 AET39163.1 - 0.05 13.5 0.4 6 6.9 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function, DUF485 DUF3341 PF11821.8 AET39163.1 - 0.057 13.1 0.1 0.21 11.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3341) TMEMspv1-c74-12 PF11044.8 AET39163.1 - 0.16 11.9 0.2 0.16 11.9 0.2 1.7 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein EamA PF00892.20 AET39165.1 - 2.6e-10 40.6 40.2 1.9e-07 31.3 15.3 3.1 3 0 0 3 3 3 2 EamA-like transporter family DUF3955 PF13127.6 AET39165.1 - 3.7e-08 33.1 2.6 3.7e-08 33.1 2.6 5.2 6 0 0 6 6 6 1 Protein of unknown function (DUF3955) OST3_OST6 PF04756.13 AET39166.1 - 2.5e-66 224.0 3.5 2.9e-66 223.8 3.5 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.20 AET39166.1 - 0.028 14.4 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin DUF2157 PF09925.9 AET39166.1 - 3.3 7.5 8.1 0.99 9.2 1.9 2.7 3 0 0 3 3 3 0 Predicted membrane protein (DUF2157) LRS4 PF10422.9 AET39167.1 - 9.3e-26 90.9 15.2 2.4e-25 89.6 15.2 1.7 1 1 0 1 1 1 1 Monopolin complex subunit LRS4 FUSC PF04632.12 AET39167.1 - 0.034 12.7 0.1 0.038 12.5 0.1 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF2756 PF10956.8 AET39167.1 - 2.4 8.7 6.8 7.2 7.2 6.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2756) DivIC PF04977.15 AET39167.1 - 3.1 7.6 8.5 4.6 7.1 7.3 1.9 1 1 0 1 1 1 0 Septum formation initiator Abhydrolase_1 PF00561.20 AET39168.1 - 0.89 9.1 5.9 0.44 10.2 0.1 2.8 2 2 1 3 3 3 0 alpha/beta hydrolase fold UDG PF03167.19 AET39169.1 - 6.9e-22 78.1 0.0 1.1e-21 77.4 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily DOT1 PF08123.13 AET39170.1 - 6.5e-86 287.1 0.7 1.8e-85 285.6 0.0 2.0 2 1 0 2 2 2 1 Histone methylation protein DOT1 Ima1_N PF09779.9 AET39170.1 - 3 8.7 5.2 4.9 8.0 4.0 2.0 1 1 1 2 2 2 0 Ima1 N-terminal domain Pribosyltran PF00156.27 AET39171.1 - 5.1e-14 52.1 0.0 6e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AET39171.1 - 0.009 15.5 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Nse5 PF08691.10 AET39172.1 - 8.7e-99 331.5 4.4 1.1e-98 331.2 4.4 1.0 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 Med13_N PF11597.8 AET39173.1 - 2e-68 231.1 2.2 4e-68 230.1 2.2 1.5 1 0 0 1 1 1 1 Mediator complex subunit 13 N-terminal Med13_C PF06333.12 AET39173.1 - 7.4e-24 84.6 10.9 5e-19 68.7 0.2 3.3 3 1 1 4 4 4 2 Mediator complex subunit 13 C-terminal domain DUF676 PF05057.14 AET39174.1 - 1.6e-48 165.1 0.0 2.5e-48 164.5 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF915 PF06028.11 AET39174.1 - 0.0019 17.6 0.0 0.0042 16.4 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Lipase_3 PF01764.25 AET39174.1 - 0.0042 17.0 0.0 0.0078 16.1 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 AET39174.1 - 0.016 15.8 0.2 0.034 14.7 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 AET39174.1 - 0.12 12.0 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 AET39174.1 - 0.17 11.6 0.1 0.37 10.5 0.1 1.5 1 0 0 1 1 1 0 PGAP1-like protein FAD-oxidase_C PF02913.19 AET39175.1 - 1.8e-52 178.5 0.0 2.9e-52 177.8 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 AET39175.1 - 1.1e-34 119.2 0.1 2.4e-34 118.0 0.1 1.7 1 0 0 1 1 1 1 FAD binding domain ECM11 PF15463.6 AET39176.1 - 1.7e-18 67.5 2.3 3.5e-18 66.5 2.3 1.5 1 0 0 1 1 1 1 Extracellular mutant protein 11 CREPT PF16566.5 AET39176.1 - 0.0094 16.1 2.5 0.02 15.0 2.5 1.7 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour Ribosomal_S17e PF00833.18 AET39177.1 - 1.9e-54 182.8 0.2 2.3e-54 182.5 0.2 1.1 1 0 0 1 1 1 1 Ribosomal S17 ZZ PF00569.17 AET39178.1 - 2.1e-15 56.3 8.2 2.1e-15 56.3 8.2 1.8 2 0 0 2 2 2 1 Zinc finger, ZZ type SWIRM PF04433.17 AET39178.1 - 2.6e-10 40.5 0.1 2.5e-07 30.9 0.0 2.9 2 0 0 2 2 2 2 SWIRM domain Myb_DNA-binding PF00249.31 AET39178.1 - 3.4e-08 33.5 0.0 8.1e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AET39178.1 - 0.00052 20.2 0.0 0.0013 18.9 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain U3_assoc_6 PF08640.11 AET39179.1 - 1.4e-29 101.9 11.4 1.7e-29 101.7 3.3 3.5 3 1 1 4 4 4 1 U3 small nucleolar RNA-associated protein 6 NRDE-2 PF08424.10 AET39179.1 - 4.5e-05 22.7 4.6 0.0005 19.3 0.8 2.2 1 1 1 2 2 2 2 NRDE-2, necessary for RNA interference TPR_14 PF13428.6 AET39179.1 - 0.0015 19.1 0.0 4.1 8.5 0.0 3.0 1 1 2 3 3 3 2 Tetratricopeptide repeat Suf PF05843.14 AET39179.1 - 0.0089 16.0 9.9 0.023 14.7 3.8 3.8 3 1 0 3 3 3 1 Suppressor of forked protein (Suf) HAT PF02184.16 AET39179.1 - 0.074 13.0 1.3 0.73 9.8 0.3 2.4 2 0 0 2 2 2 0 HAT (Half-A-TPR) repeat Ribosomal_L4 PF00573.22 AET39180.1 - 4e-50 170.2 0.0 4.8e-50 169.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribosomal_S13 PF00416.22 AET39181.1 - 3.9e-57 192.1 2.4 4.5e-57 192.0 2.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 AET39181.1 - 0.0003 19.7 0.0 0.00036 19.4 0.0 1.2 1 1 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) HHH_6 PF14579.6 AET39181.1 - 0.049 13.9 0.1 0.25 11.6 0.1 2.1 1 1 1 2 2 2 0 Helix-hairpin-helix motif FTA4 PF13093.6 AET39181.1 - 0.05 13.5 0.1 0.065 13.1 0.1 1.1 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Homeodomain PF00046.29 AET39182.1 - 4.4e-17 61.7 7.1 8.6e-17 60.7 7.1 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 AET39182.1 - 0.0013 18.6 0.4 0.0031 17.4 0.4 1.6 1 0 0 1 1 1 1 Homeobox KN domain AhpC-TSA PF00578.21 AET39183.1 - 4.3e-33 113.9 0.0 3.2e-32 111.0 0.0 1.9 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 AET39183.1 - 4.1e-18 65.5 0.0 1.3e-17 63.8 0.0 1.6 2 0 0 2 2 2 1 Redoxin 1-cysPrx_C PF10417.9 AET39183.1 - 4.5e-06 26.4 0.0 8.3e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin ubiquitin PF00240.23 AET39184.1 - 0.012 15.3 0.0 0.044 13.5 0.0 1.9 1 0 0 1 1 1 0 Ubiquitin family HIG_1_N PF04588.13 AET39185.1 - 4.1e-17 62.1 0.4 7.6e-17 61.3 0.4 1.4 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Citrate_bind PF16114.5 AET39185.1 - 0.11 12.0 0.2 0.72 9.3 0.0 1.9 1 1 0 2 2 2 0 ATP citrate lyase citrate-binding Pox_A51 PF04948.13 AET39185.1 - 0.18 10.6 0.0 0.23 10.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus A51 protein TssC PF17541.2 AET39185.1 - 1.8 7.3 6.4 2.3 7.0 6.4 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssC, VipB DUF4485 PF14846.6 AET39185.1 - 4 7.6 7.0 3.9 7.6 4.2 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4485) Guanylate_kin PF00625.21 AET39186.1 - 5.5e-69 231.5 0.0 6.3e-69 231.3 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 AET39186.1 - 1.5e-06 28.7 0.0 4.2e-06 27.2 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 AET39186.1 - 2.1e-05 25.1 0.0 3.3e-05 24.4 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AET39186.1 - 7.1e-05 23.0 0.0 0.00042 20.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AET39186.1 - 7.4e-05 23.0 0.0 0.00017 21.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 AET39186.1 - 9e-05 22.5 0.1 0.00035 20.6 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 AET39186.1 - 0.0001 22.7 0.1 0.00028 21.2 0.1 1.8 2 1 0 2 2 2 1 RNA helicase AAA PF00004.29 AET39186.1 - 0.0016 18.8 0.2 0.0033 17.8 0.2 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 AET39186.1 - 0.0023 18.2 0.1 0.0059 16.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 AET39186.1 - 0.0023 17.7 0.1 0.0039 16.9 0.1 1.7 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 AET39186.1 - 0.005 15.9 0.0 0.009 15.1 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_tran PF00005.27 AET39186.1 - 0.0054 17.2 0.0 0.0066 17.0 0.0 1.6 1 1 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 AET39186.1 - 0.0055 16.6 0.0 0.0096 15.8 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_7 PF12775.7 AET39186.1 - 0.0077 15.8 0.1 0.015 14.9 0.0 1.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_30 PF13604.6 AET39186.1 - 0.0084 15.9 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 AET39186.1 - 0.0086 16.0 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain NACHT PF05729.12 AET39186.1 - 0.0093 15.9 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 1 NACHT domain KRTDAP PF15200.6 AET39186.1 - 0.0095 15.7 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 Keratinocyte differentiation-associated AAA_14 PF13173.6 AET39186.1 - 0.01 15.9 0.0 0.02 14.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 AET39186.1 - 0.013 15.2 0.2 0.041 13.6 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF2075 PF09848.9 AET39186.1 - 0.027 13.7 0.0 0.041 13.1 0.0 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 AET39186.1 - 0.033 14.1 0.1 0.052 13.5 0.1 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 AET39186.1 - 0.035 14.0 0.2 0.052 13.5 0.2 1.5 1 1 0 1 1 1 0 NTPase AAA_19 PF13245.6 AET39186.1 - 0.07 13.5 0.1 0.32 11.3 0.0 2.0 1 1 1 2 2 2 0 AAA domain MobB PF03205.14 AET39186.1 - 0.086 12.7 0.0 0.51 10.2 0.0 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Viral_helicase1 PF01443.18 AET39186.1 - 0.12 12.1 0.1 0.23 11.2 0.1 1.6 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase cobW PF02492.19 AET39186.1 - 0.13 11.8 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Phage_Arf PF17585.2 AET39186.1 - 0.14 12.2 0.5 0.53 10.3 0.1 2.0 2 0 0 2 2 2 0 Accessory recombination function protein Na_H_Exchanger PF00999.21 AET39187.1 - 1e-67 228.6 38.3 1.2e-67 228.3 38.3 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Myc_target_1 PF15179.6 AET39187.1 - 0.043 13.7 0.4 0.091 12.7 0.4 1.5 1 0 0 1 1 1 0 Myc target protein 1 K1 PF02960.14 AET39187.1 - 0.63 10.2 3.0 0.8 9.8 0.2 2.5 2 0 0 2 2 2 0 K1 glycoprotein Wzy_C PF04932.15 AET39187.1 - 0.88 9.2 0.0 0.88 9.2 0.0 3.3 3 1 0 3 3 3 0 O-Antigen ligase Ndc1_Nup PF09531.10 AET39188.1 - 1.2e-96 324.8 28.4 4.9e-96 322.8 28.4 1.8 1 1 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Rad52_Rad22 PF04098.15 AET39189.1 - 2.6e-56 189.8 0.0 3.8e-56 189.3 0.0 1.3 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein HECT PF00632.25 AET39190.1 - 4.2e-89 299.1 0.1 1.9e-88 296.9 0.0 2.3 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) DUF908 PF06012.12 AET39190.1 - 1.4e-57 195.7 7.3 1.4e-57 195.7 7.3 3.5 3 1 0 3 3 3 1 Domain of Unknown Function (DUF908) DUF913 PF06025.12 AET39190.1 - 1.4e-50 172.4 10.1 3.9e-50 170.9 0.0 3.8 3 0 0 3 3 3 2 Domain of Unknown Function (DUF913) UBM PF14377.6 AET39190.1 - 7.9e-17 60.1 6.2 1.1e-08 34.2 0.1 2.7 2 0 0 2 2 2 2 Ubiquitin binding region MSC PF09402.10 AET39191.1 - 6.4e-111 371.1 6.5 1.6e-110 369.7 6.5 1.7 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.7 AET39191.1 - 5.4e-13 48.4 0.1 1.4e-12 47.1 0.1 1.8 1 0 0 1 1 1 1 HeH/LEM domain EF-hand_1 PF00036.32 AET39191.1 - 0.12 12.0 0.2 4.3 7.1 0.0 2.9 2 0 0 2 2 2 0 EF hand A_deaminase PF00962.22 AET39192.1 - 2.1e-127 425.0 0.0 3.1e-127 424.5 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase DHHC PF01529.20 AET39193.1 - 9.4e-27 93.7 9.7 9.4e-27 93.7 9.7 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase ABC2_membrane_3 PF12698.7 AET39193.1 - 0.0033 16.6 8.1 0.0033 16.6 8.1 1.7 2 0 0 2 2 2 1 ABC-2 family transporter protein EI24 PF07264.11 AET39193.1 - 0.056 13.7 8.8 0.14 12.4 8.1 1.9 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) DUF805 PF05656.14 AET39193.1 - 3.3 8.1 7.3 0.7 10.3 1.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF805) DUF4149 PF13664.6 AET39193.1 - 6.4 7.2 9.0 0.22 11.9 2.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) MAT1 PF06391.13 AET39194.1 - 1.5e-63 214.3 27.6 2e-63 213.9 27.6 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 AET39194.1 - 9.8e-29 99.0 7.7 1.8e-28 98.1 7.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AET39194.1 - 0.00029 20.6 5.0 0.00067 19.4 5.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AET39194.1 - 0.0003 21.0 6.1 0.00055 20.2 6.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 AET39194.1 - 0.00083 19.2 5.2 0.0015 18.3 5.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AET39194.1 - 0.0035 17.2 4.3 0.013 15.4 4.3 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FliS PF02561.14 AET39194.1 - 0.0067 16.7 1.7 0.0067 16.7 1.7 2.3 1 1 1 2 2 2 1 Flagellar protein FliS zf-RING_UBOX PF13445.6 AET39194.1 - 0.03 14.3 6.3 0.064 13.3 6.3 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Zn_ribbon_17 PF17120.5 AET39194.1 - 0.045 13.4 1.2 0.092 12.4 1.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 AET39194.1 - 0.087 12.8 9.1 1.2 9.1 9.2 2.3 1 1 1 2 2 2 0 zinc-RING finger domain UPF0160 PF03690.13 AET39194.1 - 0.13 11.9 5.5 0.16 11.6 5.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0160) 3HCDH_N PF02737.18 AET39194.1 - 0.29 11.0 4.0 0.49 10.3 4.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3H PF02829.14 AET39194.1 - 0.99 9.7 5.0 0.28 11.5 0.6 2.3 2 1 0 3 3 2 0 3H domain zf-RING_4 PF14570.6 AET39194.1 - 1.1 9.1 9.6 9.9 6.1 9.6 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 AET39194.1 - 1.1 9.2 8.7 4.8 7.1 3.0 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 DUF3797 PF12677.7 AET39194.1 - 3.3 7.7 6.0 1.5 8.7 2.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) CGI-121 PF08617.10 AET39195.1 - 5.8e-35 120.8 0.7 7.1e-35 120.5 0.7 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 Sel1 PF08238.12 AET39196.1 - 1.2e-32 111.6 5.1 5.7e-05 23.6 0.0 7.2 8 0 0 8 8 8 6 Sel1 repeat TPR_2 PF07719.17 AET39196.1 - 5.4 7.4 8.6 31 5.0 0.5 5.6 6 1 0 6 6 6 0 Tetratricopeptide repeat DUF3767 PF12597.8 AET39197.1 - 4.6e-35 119.5 0.4 6e-35 119.1 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) CPP1-like PF11833.8 AET39197.1 - 0.034 13.8 0.0 0.04 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like LigB PF02900.18 AET39198.1 - 1.3e-26 93.3 0.0 1.2e-19 70.4 0.0 2.1 2 0 0 2 2 2 2 Catalytic LigB subunit of aromatic ring-opening dioxygenase Ribosomal_L10 PF00466.20 AET39200.1 - 9.3e-08 32.1 0.0 1.7e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 Methyltransf_4 PF02390.17 AET39201.1 - 9.4e-60 201.0 0.1 1.2e-59 200.6 0.1 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 AET39201.1 - 4.1e-05 24.2 0.0 0.00038 21.1 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 AET39201.1 - 0.0042 16.6 0.0 0.015 14.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 AET39201.1 - 0.0049 17.6 0.0 0.016 15.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AET39201.1 - 0.0089 15.8 0.0 0.018 14.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AET39201.1 - 0.0095 15.3 0.0 0.032 13.6 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 AET39201.1 - 0.048 14.3 0.0 1.6 9.5 0.0 2.9 2 1 0 2 2 2 0 Methyltransferase domain Mito_carr PF00153.27 AET39202.1 - 1.4e-30 105.0 0.8 1.4e-14 53.7 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein CFIA_Pcf11 PF11526.8 AET39203.1 - 7.7e-22 77.6 3.0 7.7e-22 77.6 3.0 2.5 2 0 0 2 2 2 1 Subunit of cleavage factor IA Pcf11 CTD_bind PF04818.13 AET39203.1 - 0.034 15.0 0.0 0.18 12.7 0.0 2.3 1 0 0 1 1 1 0 RNA polymerase II-binding domain. SIR4_SID PF16991.5 AET39204.1 - 3.5e-16 59.7 2.1 3.5e-16 59.7 2.1 4.2 5 1 0 5 5 5 1 Sir4 SID domain TTRAP PF14203.6 AET39204.1 - 0.2 11.7 7.2 0.065 13.2 2.0 2.4 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein DUF5600 PF18150.1 AET39204.1 - 0.41 11.3 5.0 3.2 8.4 0.9 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5600) SIR4_SID PF16991.5 AET39205.1 - 5.3e-39 133.9 1.4 5.3e-39 133.9 1.4 4.7 5 0 0 5 5 5 1 Sir4 SID domain ADK PF00406.22 AET39206.1 - 1.8e-61 206.7 0.0 2.1e-61 206.4 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 AET39206.1 - 6.8e-24 84.8 0.2 2e-23 83.3 0.1 1.7 1 1 1 2 2 2 1 AAA domain ADK_lid PF05191.14 AET39206.1 - 5.6e-16 58.2 0.0 1.4e-15 57.0 0.0 1.7 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 AET39206.1 - 9.6e-07 29.1 0.0 3.3e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 AET39206.1 - 2.4e-05 24.9 0.0 5.7e-05 23.7 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 AET39206.1 - 0.017 14.8 0.0 0.027 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 AET39206.1 - 0.16 11.6 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase Thymidylate_kin PF02223.17 AET39206.1 - 0.17 11.5 0.0 2.7 7.6 0.0 2.4 1 1 1 3 3 3 0 Thymidylate kinase zf-C2H2 PF00096.26 AET39207.1 - 8.2e-10 38.6 13.6 2.1e-05 24.7 0.3 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AET39207.1 - 2.9e-07 30.8 12.1 0.0011 19.6 0.3 3.2 3 0 0 3 3 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AET39207.1 - 1.3e-06 28.6 16.4 8e-05 22.9 0.6 4.2 4 0 0 4 4 4 3 Zinc-finger double domain zf-met PF12874.7 AET39207.1 - 9.6e-06 25.8 5.5 0.0031 17.8 0.1 3.3 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AET39207.1 - 0.0003 21.0 2.3 0.58 10.5 0.0 2.8 3 0 0 3 3 2 2 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 AET39207.1 - 0.014 15.2 3.9 0.62 10.0 0.1 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 AET39207.1 - 0.029 14.4 5.7 2.1 8.5 1.7 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Zn-C2H2_12 PF18112.1 AET39207.1 - 0.077 13.5 1.8 0.093 13.2 0.0 2.2 2 0 0 2 2 1 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_2 PF12756.7 AET39207.1 - 0.13 12.6 4.3 17 5.8 0.0 3.3 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) DUF2256 PF10013.9 AET39207.1 - 0.17 12.0 5.9 0.18 12.0 0.2 2.6 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-Di19 PF05605.12 AET39207.1 - 0.33 11.3 6.2 0.2 11.9 2.4 2.5 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.10 AET39207.1 - 0.49 10.5 2.8 24 5.1 0.2 3.0 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2H2_11 PF16622.5 AET39207.1 - 0.72 9.7 4.5 15 5.4 0.1 2.6 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-BED PF02892.15 AET39207.1 - 3.6 7.7 8.2 19 5.4 0.2 3.3 2 1 1 3 3 3 0 BED zinc finger Histone_H2A_C PF16211.5 AET39209.1 - 3e-21 74.8 1.0 5.1e-21 74.1 1.0 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 AET39209.1 - 5.8e-18 65.5 0.0 7.7e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AET39209.1 - 3.3e-06 27.3 0.0 5.1e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone LcrG PF07216.12 AET39209.1 - 0.066 13.1 0.0 0.099 12.6 0.0 1.3 1 0 0 1 1 1 0 LcrG protein Histone PF00125.24 AET39210.1 - 1e-20 74.4 3.1 1.3e-20 74.1 3.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AET39210.1 - 3.3e-06 27.3 0.1 7.4e-06 26.2 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 AET39210.1 - 0.002 18.6 0.0 0.0036 17.8 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CENP-W PF15510.6 AET39210.1 - 0.015 15.5 0.0 0.023 14.9 0.0 1.2 1 0 0 1 1 1 0 CENP-W protein YscO-like PF16789.5 AET39210.1 - 0.068 13.2 0.1 0.079 13.0 0.1 1.1 1 0 0 1 1 1 0 YscO-like protein VIT1 PF01988.19 AET39211.1 - 1.8e-60 204.5 0.1 2.2e-60 204.2 0.1 1.1 1 0 0 1 1 1 1 VIT family T3RM_EcoP15I_C PF18273.1 AET39211.1 - 0.066 13.5 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 Type III R-M EcoP15I C-terminal domain Pannexin_like PF12534.8 AET39211.1 - 0.23 10.5 0.5 0.34 10.0 0.5 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Rsa3 PF14615.6 AET39212.1 - 4.3e-20 71.0 0.4 7.8e-20 70.2 0.4 1.4 1 0 0 1 1 1 1 Ribosome-assembly protein 3 SR-25 PF10500.9 AET39212.1 - 0.075 12.6 12.7 0.098 12.3 12.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3827 PF12877.7 AET39212.1 - 1.3 7.3 10.1 1.5 7.1 10.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) NPR3 PF03666.13 AET39212.1 - 6.5 5.4 11.0 8.5 5.0 11.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Utp13 PF08625.11 AET39213.1 - 1.9e-52 177.0 0.4 3.2e-52 176.2 0.4 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain WD40 PF00400.32 AET39213.1 - 1.7e-45 152.1 23.0 2.3e-06 28.2 0.0 10.8 10 1 1 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET39213.1 - 2.2e-23 82.4 7.2 0.00011 22.4 0.0 7.5 5 3 1 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AET39213.1 - 1.5e-07 31.0 5.6 0.031 13.6 0.1 5.2 4 3 1 6 6 6 3 WD40-like domain Nup160 PF11715.8 AET39213.1 - 8.3e-07 28.0 10.0 1.3 7.6 0.1 6.5 2 2 3 6 6 6 4 Nucleoporin Nup120/160 eIF2A PF08662.11 AET39213.1 - 0.00047 20.1 0.9 3.8 7.3 0.0 4.1 2 2 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 AET39213.1 - 0.0057 15.4 2.3 1.6 7.4 0.0 4.0 2 1 2 4 4 4 1 Nup133 N terminal like Utp12 PF04003.12 AET39213.1 - 0.036 14.4 0.1 0.07 13.5 0.1 1.5 1 0 0 1 1 1 0 Dip2/Utp12 Family CRF1 PF10380.9 AET39214.1 - 3.1e-34 117.7 2.0 3.1e-34 117.7 2.0 3.5 3 2 0 3 3 3 1 Transcription factor CRF1 PRKCSH-like PF12999.7 AET39215.1 - 7.8e-46 156.1 5.6 7.8e-46 156.1 5.6 2.7 1 1 2 3 3 3 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 AET39215.1 - 2.7e-22 79.1 9.7 9e-22 77.4 0.5 3.9 3 1 0 3 3 3 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 AET39215.1 - 0.0022 19.0 0.0 0.0077 17.2 0.0 2.0 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Speriolin_C PF15059.6 AET39215.1 - 0.0051 16.9 2.0 0.78 9.9 0.1 3.2 2 1 1 3 3 3 1 Speriolin C-terminus Caps_synth_GfcC PF06251.11 AET39215.1 - 0.017 14.8 0.5 0.36 10.4 0.1 2.5 2 0 0 2 2 2 0 Capsule biosynthesis GfcC Phasin_2 PF09361.10 AET39215.1 - 0.17 12.1 0.5 23 5.3 0.0 3.2 3 0 0 3 3 3 0 Phasin protein Seryl_tRNA_N PF02403.22 AET39215.1 - 0.18 12.0 2.8 6.3 7.1 0.0 3.4 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain ApoLp-III PF07464.11 AET39215.1 - 0.2 11.8 6.7 17 5.5 0.1 3.8 4 0 0 4 4 4 0 Apolipophorin-III precursor (apoLp-III) DUF4208 PF13907.6 AET39215.1 - 0.23 11.9 1.0 4.3 7.8 0.0 3.3 2 1 0 3 3 3 0 Domain of unknown function (DUF4208) DUF1664 PF07889.12 AET39215.1 - 0.39 10.8 5.3 6.7 6.8 0.0 2.7 3 0 0 3 3 2 0 Protein of unknown function (DUF1664) TBCC_N PF16752.5 AET39215.1 - 0.71 10.3 4.8 2.1 8.8 0.2 3.0 3 0 0 3 3 3 0 Tubulin-specific chaperone C N-terminal domain APG6_N PF17675.1 AET39215.1 - 0.72 10.4 13.5 0.068 13.7 2.3 2.9 3 1 0 3 3 2 0 Apg6 coiled-coil region TF_AP-2 PF03299.14 AET39215.1 - 0.79 9.6 3.5 8.1 6.4 0.5 3.0 3 1 1 4 4 4 0 Transcription factor AP-2 Apolipoprotein PF01442.18 AET39215.1 - 0.97 9.3 6.2 6.9 6.5 0.9 3.1 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF3958 PF13125.6 AET39215.1 - 1.1 9.5 4.8 6.2 7.1 0.6 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3958) DUF1002 PF06207.11 AET39215.1 - 1.1 8.7 7.0 5.1 6.6 1.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1002) F-box-like PF12937.7 AET39216.1 - 2.4e-05 24.2 0.0 5.8e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 AET39216.1 - 0.00016 21.5 0.0 0.00035 20.4 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 AET39216.1 - 0.014 15.3 0.1 0.014 15.3 0.1 1.6 2 0 0 2 2 2 0 F-box PRANC PF09372.10 AET39216.1 - 0.29 11.5 3.1 1 9.7 0.0 2.9 3 1 1 4 4 4 0 PRANC domain Septin PF00735.18 AET39218.1 - 8.6e-79 264.7 3.6 4.3e-78 262.4 3.6 1.9 1 1 0 1 1 1 1 Septin Dynamin_N PF00350.23 AET39218.1 - 0.00049 20.2 0.1 0.0016 18.5 0.0 1.9 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 AET39218.1 - 0.00095 19.2 0.0 0.0023 18.0 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 AET39218.1 - 0.0018 18.0 0.0 0.045 13.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 AET39218.1 - 0.0021 18.0 0.0 0.32 10.9 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 AET39218.1 - 0.0025 18.1 0.0 0.0055 17.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain Pox_A32 PF04665.12 AET39218.1 - 0.003 17.1 0.4 0.0057 16.2 0.0 1.6 2 0 0 2 2 2 1 Poxvirus A32 protein G-alpha PF00503.20 AET39218.1 - 0.0036 16.5 7.8 0.097 11.8 0.0 3.8 2 1 1 4 4 4 1 G-protein alpha subunit T2SSE PF00437.20 AET39218.1 - 0.0054 15.8 0.0 0.01 14.9 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_tran PF00005.27 AET39218.1 - 0.0066 17.0 1.6 0.026 15.1 0.1 2.4 2 1 0 2 2 2 1 ABC transporter FtsK_SpoIIIE PF01580.18 AET39218.1 - 0.0091 15.4 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family PduV-EutP PF10662.9 AET39218.1 - 0.0094 15.7 0.2 0.16 11.7 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Microtub_bd PF16796.5 AET39218.1 - 0.012 15.5 0.0 0.034 14.1 0.0 1.7 1 0 0 1 1 1 0 Microtubule binding Roc PF08477.13 AET39218.1 - 0.014 15.6 0.0 0.066 13.4 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 AET39218.1 - 0.017 15.7 1.3 0.026 15.1 0.2 1.9 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 AET39218.1 - 0.031 14.4 0.0 0.11 12.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 AET39218.1 - 0.033 13.7 0.0 4.2 6.9 0.0 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain cobW PF02492.19 AET39218.1 - 0.036 13.7 0.2 0.13 11.8 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 AET39218.1 - 0.036 14.0 0.0 0.11 12.5 0.0 1.7 2 0 0 2 2 1 0 NACHT domain IIGP PF05049.13 AET39218.1 - 0.054 12.5 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) ATPase_2 PF01637.18 AET39218.1 - 0.057 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 AET39218.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 AET39218.1 - 0.12 12.8 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Rad9_Rad53_bind PF08605.10 AET39220.1 - 1.4e-43 148.1 0.2 3.4e-43 146.9 0.2 1.7 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding BRCT PF00533.26 AET39220.1 - 1.6e-09 38.0 0.4 6.8e-09 36.0 0.4 2.2 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 AET39220.1 - 0.0018 18.1 0.0 0.0054 16.6 0.0 1.8 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 AET39220.1 - 0.002 18.5 0.5 0.019 15.4 0.1 2.8 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain Aha1_N PF09229.11 AET39221.1 - 1.9e-33 115.6 0.0 3e-33 114.9 0.0 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 AET39221.1 - 3.2e-10 40.3 0.0 4.9e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Fungal_trans_2 PF11951.8 AET39222.1 - 1.1e-11 44.1 0.8 1.1e-11 44.1 0.8 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET39222.1 - 1.9e-06 27.9 18.4 3.4e-06 27.1 18.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Band_3_cyto PF07565.13 AET39222.1 - 0.15 11.8 22.9 0.47 10.2 22.9 1.9 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SID-1_RNA_chan PF13965.6 AET39222.1 - 4.4 5.6 6.3 6.5 5.0 6.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CLN3 PF02487.17 AET39222.1 - 9.1 5.2 13.4 18 4.2 13.4 1.5 1 0 0 1 1 1 0 CLN3 protein Cpn60_TCP1 PF00118.24 AET39223.1 - 1.3e-149 499.0 12.0 1.6e-149 498.7 12.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ras PF00071.22 AET39224.1 - 2.6e-51 173.5 0.0 3e-51 173.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET39224.1 - 1.6e-18 67.0 0.0 2.3e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET39224.1 - 1.7e-07 30.8 0.0 2.3e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family W2 PF02020.18 AET39225.1 - 2.5e-13 50.0 0.1 9.3e-13 48.1 0.1 2.0 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon NTP_transferase PF00483.23 AET39225.1 - 5.4e-11 42.6 0.0 2e-10 40.7 0.0 2.0 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.24 AET39225.1 - 1.5e-08 34.1 15.6 0.012 15.3 2.3 3.7 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 AET39225.1 - 0.00012 20.3 11.2 0.00066 17.9 1.2 2.0 2 1 1 3 3 3 2 Domain of unknown function (DUF4954) NTP_transf_3 PF12804.7 AET39225.1 - 0.0075 16.6 0.0 0.015 15.7 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 AET39225.1 - 0.034 13.1 1.7 0.07 12.1 1.7 1.4 1 1 0 1 1 1 0 L-fucokinase Hexapep_2 PF14602.6 AET39225.1 - 0.035 13.9 17.1 0.043 13.6 1.2 3.4 2 1 2 4 4 4 0 Hexapeptide repeat of succinyl-transferase PIP5K PF01504.18 AET39226.1 - 5.5e-93 311.2 0.2 8.8e-93 310.5 0.2 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase FAM199X PF15814.5 AET39226.1 - 1 8.4 4.2 1.7 7.6 4.2 1.4 1 0 0 1 1 1 0 Protein family FAM199X E1-E2_ATPase PF00122.20 AET39227.1 - 4.2e-33 114.4 22.3 4.6e-28 98.0 0.3 3.7 4 0 0 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 AET39227.1 - 2.5e-29 102.3 3.5 2.5e-29 102.3 3.5 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 AET39227.1 - 2.4e-20 72.4 0.1 5.1e-20 71.4 0.1 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 AET39227.1 - 6.8e-20 72.3 0.1 9.1e-16 58.8 0.0 2.6 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 AET39227.1 - 2.2e-12 46.5 0.0 5.4e-12 45.2 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 AET39227.1 - 0.0011 18.8 0.8 0.0065 16.2 1.2 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Aminotran_5 PF00266.19 AET39228.1 - 3.1e-15 56.0 0.0 4.3e-15 55.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V EST1_DNA_bind PF10373.9 AET39229.1 - 2.7e-56 191.1 0.3 2.7e-56 191.1 0.3 2.1 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.9 AET39229.1 - 5e-22 79.0 1.9 5e-22 79.0 1.9 2.6 2 1 0 2 2 2 1 Telomerase activating protein Est1 PAT1 PF09770.9 AET39229.1 - 0.28 9.4 4.4 0.39 8.9 4.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Zn_clus PF00172.18 AET39230.1 - 4.1e-11 42.8 7.5 7.1e-11 42.1 7.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Topoisom_bac PF01131.20 AET39231.1 - 2e-104 349.9 0.0 2.3e-104 349.7 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 AET39231.1 - 2.7e-17 62.9 0.0 7.8e-17 61.4 0.0 1.8 1 0 0 1 1 1 1 Toprim domain Cation_efflux PF01545.21 AET39232.1 - 7e-40 136.9 15.5 7e-40 136.9 15.5 2.7 2 1 0 2 2 2 1 Cation efflux family Zip PF02535.22 AET39232.1 - 0.0049 16.1 6.6 0.0049 16.1 6.6 3.2 3 1 0 3 3 3 1 ZIP Zinc transporter MFMR_assoc PF16596.5 AET39232.1 - 0.046 14.2 4.4 0.079 13.4 4.4 1.3 1 0 0 1 1 1 0 Disordered region downstream of MFMR EOS1 PF12326.8 AET39232.1 - 3.2 7.7 12.1 1 9.2 2.0 2.6 3 0 0 3 3 3 0 N-glycosylation protein Coq4 PF05019.13 AET39233.1 - 9.5e-84 280.1 0.1 1.2e-83 279.9 0.1 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Rogdi_lz PF10259.9 AET39234.1 - 7.1e-61 206.0 0.4 8.1e-61 205.8 0.4 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein TPD52 PF04201.15 AET39234.1 - 0.07 12.7 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Tumour protein D52 family DASH_Spc19 PF08287.11 AET39235.1 - 4.2e-38 130.7 13.3 5.7e-38 130.3 13.3 1.2 1 0 0 1 1 1 1 Spc19 DUF4515 PF14988.6 AET39235.1 - 0.0053 16.6 8.2 0.0053 16.6 8.2 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4515) Baculo_F PF12259.8 AET39235.1 - 0.032 12.8 1.0 0.047 12.2 0.6 1.5 1 1 1 2 2 2 0 Baculovirus F protein Hid1 PF12722.7 AET39235.1 - 0.036 12.2 1.8 0.042 12.0 1.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4140 PF13600.6 AET39235.1 - 0.039 14.4 2.6 4.7 7.7 0.0 2.7 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Spc7 PF08317.11 AET39235.1 - 0.12 11.2 8.3 0.086 11.7 5.7 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein Tropomyosin_1 PF12718.7 AET39235.1 - 0.32 11.1 13.0 0.2 11.8 5.4 2.1 2 0 0 2 2 2 0 Tropomyosin like Helo_like_N PF17111.5 AET39235.1 - 0.39 10.0 7.8 0.12 11.7 3.8 1.8 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins Laminin_II PF06009.12 AET39235.1 - 0.49 10.4 7.4 0.61 10.1 1.9 2.4 2 1 0 2 2 2 0 Laminin Domain II CLZ PF16526.5 AET39235.1 - 0.57 10.6 14.8 0.38 11.1 2.7 3.4 2 1 2 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Fib_alpha PF08702.10 AET39235.1 - 0.57 10.4 8.6 2.8 8.1 3.6 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Prefoldin_2 PF01920.20 AET39235.1 - 0.69 9.9 14.4 5.3 7.0 5.0 3.0 2 1 0 2 2 2 0 Prefoldin subunit FapA PF03961.13 AET39235.1 - 0.75 8.3 4.9 1.1 7.8 4.9 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A BLOC1_2 PF10046.9 AET39235.1 - 0.81 10.0 7.6 0.82 10.0 0.5 2.9 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SKA2 PF16740.5 AET39235.1 - 0.97 9.2 9.4 0.71 9.7 0.3 2.9 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 TolA_bind_tri PF16331.5 AET39235.1 - 1 9.5 14.8 1.9 8.6 1.8 3.4 3 0 0 3 3 3 0 TolA binding protein trimerisation Exonuc_VII_L PF02601.15 AET39235.1 - 2.3 7.7 6.2 2.9 7.4 6.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit CENP-H PF05837.12 AET39235.1 - 2.4 8.6 9.8 0.91 10.0 3.5 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DASH_Duo1 PF08651.10 AET39235.1 - 3.3 7.6 8.5 4.7 7.1 0.2 3.0 3 0 0 3 3 3 0 DASH complex subunit Duo1 Prefoldin PF02996.17 AET39235.1 - 7.6 6.5 9.5 3.1 7.8 0.4 3.0 3 0 0 3 3 3 0 Prefoldin subunit DASH_Dad2 PF08654.10 AET39235.1 - 9.8 6.7 9.1 4.7 7.7 1.4 2.8 3 0 0 3 3 3 0 DASH complex subunit Dad2 FHA PF00498.26 AET39236.1 - 5.9e-19 68.2 1.3 6.2e-18 64.9 0.4 2.9 3 0 0 3 3 3 1 FHA domain Yop-YscD_cpl PF16697.5 AET39236.1 - 3.9e-05 23.9 0.2 0.00018 21.8 0.0 2.1 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain DUF948 PF06103.11 AET39236.1 - 0.093 13.0 1.4 0.27 11.5 1.4 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) LMBR1 PF04791.16 AET39236.1 - 0.57 9.0 3.1 0.74 8.6 3.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Exonuc_VII_L PF02601.15 AET39236.1 - 0.76 9.3 9.2 1.2 8.6 9.2 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Herpes_BLRF2 PF05812.12 AET39236.1 - 1.7 8.8 8.4 0.54 10.4 4.6 2.1 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein BPL_LplA_LipB PF03099.19 AET39237.1 - 1.7e-20 73.2 0.1 3.3e-20 72.3 0.1 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family SET PF00856.28 AET39238.1 - 0.024 15.0 0.0 0.073 13.4 0.0 1.7 1 1 0 1 1 1 0 SET domain ApbA_C PF08546.11 AET39239.1 - 4.6e-20 72.1 0.1 6.8e-20 71.5 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal CoaE PF01121.20 AET39240.1 - 1.6e-60 203.8 0.0 2.4e-60 203.3 0.0 1.2 1 0 0 1 1 1 1 Dephospho-CoA kinase Cytidylate_kin2 PF13189.6 AET39240.1 - 0.0012 19.0 1.1 0.14 12.3 0.0 3.0 3 0 0 3 3 3 1 Cytidylate kinase-like family AAA_17 PF13207.6 AET39240.1 - 0.019 15.4 1.0 0.13 12.7 0.0 2.5 3 0 0 3 3 3 0 AAA domain PRK PF00485.18 AET39240.1 - 0.043 13.5 0.6 0.085 12.6 0.0 1.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 AET39240.1 - 0.045 14.3 0.5 0.25 11.9 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_28 PF13521.6 AET39240.1 - 0.1 12.8 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain P4Ha_N PF08336.11 AET39241.1 - 0.0047 16.9 1.1 0.011 15.7 1.1 1.6 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region NPV_P10 PF05531.12 AET39241.1 - 0.044 14.3 0.3 0.11 13.0 0.3 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein PhaC_N PF07167.13 AET39241.1 - 0.11 12.1 0.4 0.29 10.8 0.4 1.6 1 0 0 1 1 1 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus DEAD PF00270.29 AET39242.1 - 1.5e-41 142.0 0.5 2.1e-40 138.3 0.2 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET39242.1 - 2.8e-23 82.4 0.1 6.4e-22 78.0 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET39242.1 - 6.4e-06 26.3 0.5 2.4e-05 24.4 0.3 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 AET39242.1 - 0.0004 19.7 0.0 0.0013 18.0 0.0 1.8 1 1 1 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase AAA_30 PF13604.6 AET39242.1 - 0.043 13.5 0.0 0.079 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain PI3Ka PF00613.20 AET39243.1 - 9.1e-67 224.0 1.1 1.5e-66 223.3 1.1 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 AET39243.1 - 7.6e-49 166.8 0.0 9.6e-33 114.0 0.0 2.5 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 AET39243.1 - 7.9e-24 84.2 0.1 1.9e-23 82.9 0.1 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 RSN1_7TM PF02714.15 AET39244.1 - 1e-78 264.4 22.9 1e-78 264.4 22.9 1.6 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 AET39244.1 - 1.5e-36 125.5 0.3 1.5e-36 125.5 0.3 2.7 2 1 1 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 AET39244.1 - 4.2e-31 108.5 0.0 8.4e-31 107.6 0.0 1.5 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Arv1 PF04161.13 AET39245.1 - 2e-62 211.1 11.8 2e-62 211.1 11.8 1.6 2 0 0 2 2 2 1 Arv1-like family zf_CCCH_4 PF18345.1 AET39246.1 - 9e-06 25.6 8.3 2e-05 24.5 8.3 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 AET39246.1 - 1.1e-05 25.2 3.8 2.1e-05 24.3 3.8 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 AET39246.1 - 0.00038 20.2 2.8 0.00078 19.2 2.8 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 AET39246.1 - 0.002 18.8 0.6 0.002 18.8 0.6 1.9 2 0 0 2 2 2 1 Torus domain zf-CCCH_2 PF14608.6 AET39246.1 - 0.055 14.0 5.5 0.12 12.9 5.5 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger DUF4200 PF13863.6 AET39246.1 - 0.074 13.5 0.8 0.13 12.7 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) zf-CCCH_3 PF15663.5 AET39246.1 - 0.41 10.9 2.6 0.27 11.5 0.6 1.7 2 0 0 2 2 2 0 Zinc-finger containing family ATP_bind_1 PF03029.17 AET39247.1 - 8.6e-89 297.4 0.0 9.8e-89 297.3 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 AET39247.1 - 0.00066 19.3 0.0 0.37 10.3 0.0 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain CLP1_P PF16575.5 AET39247.1 - 0.0025 17.7 0.0 0.016 15.0 0.0 2.2 2 1 1 3 3 3 1 mRNA cleavage and polyadenylation factor CLP1 P-loop cobW PF02492.19 AET39247.1 - 0.0026 17.4 0.0 0.16 11.6 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 AET39247.1 - 0.0029 17.4 0.0 0.0052 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AET39247.1 - 0.0038 17.6 0.0 0.014 15.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 AET39247.1 - 0.0041 16.2 0.0 0.01 14.8 0.0 1.6 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 AET39247.1 - 0.006 16.5 0.5 0.29 11.0 0.1 2.6 2 1 1 3 3 3 1 RsgA GTPase AAA_18 PF13238.6 AET39247.1 - 0.007 16.9 0.0 0.019 15.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 AET39247.1 - 0.0095 16.4 0.0 0.02 15.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_31 PF13614.6 AET39247.1 - 0.01 15.8 0.0 0.54 10.2 0.0 2.3 1 1 1 2 2 2 1 AAA domain T2SSE PF00437.20 AET39247.1 - 0.011 14.8 0.0 0.017 14.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.6 AET39247.1 - 0.011 15.4 0.0 0.028 14.1 0.0 1.5 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.14 AET39247.1 - 0.012 14.9 0.0 0.028 13.7 0.0 1.5 2 0 0 2 2 2 0 KAP family P-loop domain AAA_16 PF13191.6 AET39247.1 - 0.015 15.7 0.2 0.07 13.5 0.0 2.0 1 1 1 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 AET39247.1 - 0.016 15.6 0.0 0.06 13.7 0.0 2.0 2 0 0 2 2 1 0 RNA helicase AAA_7 PF12775.7 AET39247.1 - 0.017 14.7 0.0 0.055 13.0 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region ABC_tran PF00005.27 AET39247.1 - 0.022 15.3 0.0 0.063 13.8 0.0 1.8 2 1 0 2 2 1 0 ABC transporter AAA_22 PF13401.6 AET39247.1 - 0.027 14.8 0.0 0.064 13.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 AET39247.1 - 0.028 14.3 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ATPase_2 PF01637.18 AET39247.1 - 0.032 14.1 0.0 0.17 11.7 0.0 2.2 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 AET39247.1 - 0.032 14.3 0.0 0.14 12.3 0.0 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF87 PF01935.17 AET39247.1 - 0.036 14.2 0.0 0.077 13.1 0.0 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain SRP54 PF00448.22 AET39247.1 - 0.037 13.6 0.0 0.059 13.0 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RuvB_N PF05496.12 AET39247.1 - 0.039 13.7 0.0 0.068 12.9 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain NB-ARC PF00931.22 AET39247.1 - 0.044 13.0 0.1 0.072 12.3 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_14 PF13173.6 AET39247.1 - 0.057 13.5 0.0 0.12 12.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain CbiA PF01656.23 AET39247.1 - 0.071 13.2 0.0 0.085 12.9 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Septin PF00735.18 AET39247.1 - 0.1 11.9 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Septin NTPase_1 PF03266.15 AET39247.1 - 0.1 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 NTPase DUF463 PF04317.12 AET39247.1 - 0.11 11.4 0.0 0.2 10.5 0.0 1.4 1 0 0 1 1 1 0 YcjX-like family, DUF463 ArsA_ATPase PF02374.15 AET39247.1 - 0.11 11.6 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Anion-transporting ATPase TsaE PF02367.17 AET39247.1 - 0.12 12.3 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fer4_NifH PF00142.18 AET39247.1 - 0.15 11.5 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family PduV-EutP PF10662.9 AET39247.1 - 0.15 11.8 0.0 1.8 8.3 0.0 2.4 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation RecA PF00154.21 AET39247.1 - 0.16 11.4 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 recA bacterial DNA recombination protein Sigma54_activat PF00158.26 AET39247.1 - 0.16 11.6 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain Thymidylate_kin PF02223.17 AET39247.1 - 0.17 11.5 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 Thymidylate kinase TrwB_AAD_bind PF10412.9 AET39247.1 - 0.18 10.7 0.0 0.27 10.1 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain SIR2 PF02146.17 AET39248.1 - 9.7e-31 107.1 0.0 2.4e-30 105.8 0.0 1.6 1 1 0 1 1 1 1 Sir2 family zinc-ribbons_6 PF07191.12 AET39248.1 - 0.05 13.6 1.3 0.05 13.6 1.3 2.3 2 0 0 2 2 2 0 zinc-ribbons zf-RRPl_C4 PF17026.5 AET39248.1 - 0.1 12.7 0.4 0.1 12.7 0.4 2.2 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type DUF3039 PF11238.8 AET39248.1 - 0.72 9.6 4.2 2.3 8.0 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3039) TIP49 PF06068.13 AET39249.1 - 4.5e-167 555.6 0.2 5.6e-167 555.3 0.2 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 AET39249.1 - 2.4e-20 72.4 0.1 6.3e-20 71.1 0.1 1.8 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 AET39249.1 - 4.6e-08 33.6 0.2 6.9e-05 23.3 0.1 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 AET39249.1 - 2.6e-07 30.5 0.1 8.7e-05 22.3 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 AET39249.1 - 0.0013 19.0 0.1 0.0023 18.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AET39249.1 - 0.0033 17.8 0.9 3.2 8.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain DnaB_C PF03796.15 AET39249.1 - 0.012 15.0 0.0 0.025 13.9 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Zeta_toxin PF06414.12 AET39249.1 - 0.013 14.7 0.1 0.042 13.1 0.1 1.8 2 0 0 2 2 2 0 Zeta toxin AAA_16 PF13191.6 AET39249.1 - 0.035 14.5 0.3 0.24 11.8 0.0 2.3 3 0 0 3 3 3 0 AAA ATPase domain CPT PF07931.12 AET39249.1 - 0.041 13.7 0.0 0.089 12.6 0.0 1.6 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Mg_chelatase PF01078.21 AET39249.1 - 0.055 12.8 0.1 6.7 6.0 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 AET39249.1 - 0.063 13.0 0.0 6.8 6.4 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_5 PF07728.14 AET39249.1 - 0.12 12.4 0.2 2.4 8.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Sec1 PF00995.23 AET39250.1 - 8.9e-118 395.0 4.3 1e-117 394.8 4.3 1.0 1 0 0 1 1 1 1 Sec1 family HTH_25 PF13413.6 AET39250.1 - 0.0014 18.5 0.1 0.0039 17.0 0.1 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain DUF2780 PF11075.8 AET39250.1 - 0.026 14.7 0.8 0.07 13.3 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function VcgC/VcgE (DUF2780) Cpn60_TCP1 PF00118.24 AET39251.1 - 3.4e-157 524.0 1.0 3.9e-157 523.8 1.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family dCMP_cyt_deam_1 PF00383.23 AET39252.1 - 4.7e-14 52.1 0.5 6.1e-14 51.7 0.5 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 AET39252.1 - 2.8e-13 50.2 0.5 5.6e-09 36.3 0.0 2.1 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 AET39252.1 - 0.09 12.4 2.7 3.4 7.2 0.1 2.1 1 1 0 2 2 2 0 A distinct subfamily of CDD/CDA-like deaminases Nop14 PF04147.12 AET39253.1 - 0.86 7.7 16.1 1.4 7.0 16.1 1.3 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 AET39253.1 - 3.1 7.1 13.6 5.8 6.2 13.6 1.4 1 0 0 1 1 1 0 SDA1 DNA_pol_phi PF04931.13 AET39253.1 - 5.3 5.0 20.0 11 4.0 20.0 1.5 1 0 0 1 1 1 0 DNA polymerase phi DHHC PF01529.20 AET39254.1 - 6e-32 110.6 12.6 6e-32 110.6 12.6 2.5 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF2645 PF10840.8 AET39254.1 - 0.03 15.0 2.6 0.03 15.0 2.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2645) PRELI PF04707.14 AET39255.1 - 2.1e-56 190.1 0.5 2.9e-56 189.7 0.5 1.1 1 0 0 1 1 1 1 PRELI-like family CCDC85 PF10226.9 AET39256.1 - 0.014 15.1 0.7 0.033 13.9 0.7 1.5 1 0 0 1 1 1 0 CCDC85 family ubiquitin PF00240.23 AET39257.1 - 2.5e-34 116.8 0.4 7.7e-34 115.3 0.6 1.7 2 0 0 2 2 2 1 Ubiquitin family Ribosomal_S27 PF01599.19 AET39257.1 - 4e-24 84.5 1.7 4e-24 84.5 1.7 1.8 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 AET39257.1 - 4.7e-16 58.4 0.7 4.7e-16 58.4 0.7 1.9 2 1 1 3 3 3 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 AET39257.1 - 2.5e-05 24.6 0.4 0.00012 22.4 0.1 2.1 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 AET39257.1 - 0.0011 19.1 0.6 0.0029 17.7 0.6 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 AET39257.1 - 0.0032 17.8 0.5 0.0077 16.6 0.0 1.8 1 1 1 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 AET39257.1 - 0.0052 16.7 0.0 0.008 16.1 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain IBR PF01485.21 AET39257.1 - 0.012 15.9 0.2 0.02 15.1 0.2 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain DUF2407 PF10302.9 AET39257.1 - 0.013 16.0 0.4 0.019 15.5 0.4 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 AET39257.1 - 0.019 15.0 1.0 5.7 7.1 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 AET39257.1 - 0.085 12.7 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain Fer2_3 PF13085.6 AET39257.1 - 0.11 12.5 0.4 0.18 11.8 0.4 1.5 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Phosducin PF02114.16 AET39258.1 - 5.2e-08 32.2 0.1 6.3e-08 31.9 0.1 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 AET39258.1 - 0.0013 18.7 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Sec10 PF07393.11 AET39259.1 - 1.1e-188 629.0 25.5 1.4e-188 628.7 25.5 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 RB_B PF01857.20 AET39259.1 - 0.01 15.9 0.6 0.053 13.5 0.6 2.3 1 0 0 1 1 1 0 Retinoblastoma-associated protein B domain Metallophos PF00149.28 AET39260.1 - 1.4e-13 51.9 1.3 2.3e-13 51.1 1.3 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase SAS4 PF15460.6 AET39261.1 - 1.1e-27 96.0 8.2 1.1e-27 96.0 8.2 2.0 2 0 0 2 2 2 1 Something about silencing, SAS, complex subunit 4 Nipped-B_C PF12830.7 AET39262.1 - 3.4e-41 141.3 5.3 3.6e-40 138.0 0.4 3.4 3 0 0 3 3 3 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 AET39262.1 - 6.7e-14 51.9 2.0 3.5e-13 49.6 0.3 2.9 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion PRP9_N PF16958.5 AET39262.1 - 0.027 14.5 0.7 0.26 11.3 0.1 2.9 2 0 0 2 2 2 0 Pre-mRNA-splicing factor PRP9 N-terminus HEAT PF02985.22 AET39262.1 - 0.043 14.1 1.3 39 4.9 0.0 5.0 5 0 0 5 5 5 0 HEAT repeat PseudoU_synth_2 PF00849.22 AET39263.1 - 3e-17 63.2 0.1 1.3e-15 57.8 0.1 2.3 1 1 0 1 1 1 1 RNA pseudouridylate synthase Phage_GPL PF05926.11 AET39263.1 - 0.085 12.9 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Phage head completion protein (GPL) PXA PF02194.15 AET39264.1 - 9.6e-11 42.0 0.9 4.7e-10 39.7 0.9 2.2 1 1 0 1 1 1 1 PXA domain Nexin_C PF08628.12 AET39264.1 - 0.033 14.8 0.0 0.13 12.8 0.0 2.0 2 0 0 2 2 2 0 Sorting nexin C terminal CybS PF05328.12 AET39266.1 - 2.6e-49 166.3 0.0 3e-49 166.1 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit DUF4405 PF14358.6 AET39266.1 - 0.12 13.0 0.1 0.12 13.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4405) Peptidase_M16 PF00675.20 AET39267.1 - 5.2e-52 175.8 0.0 1.5e-51 174.3 0.0 1.8 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 AET39267.1 - 3.4e-33 115.2 0.0 1.3e-32 113.3 0.0 1.8 2 0 0 2 2 2 1 Peptidase M16 inactive domain M16C_assoc PF08367.11 AET39267.1 - 0.092 11.9 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase M16C associated MRP-S28 PF10213.9 AET39268.1 - 3.3e-49 166.5 2.9 6.9e-49 165.5 2.9 1.6 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein DUF3896 PF13035.6 AET39268.1 - 0.02 15.1 0.6 0.07 13.3 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) DUF4665 PF15679.5 AET39268.1 - 0.25 12.0 3.4 0.85 10.3 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4665) HMG_box PF00505.19 AET39269.1 - 1.1e-11 44.9 2.2 1.1e-11 44.9 2.2 2.3 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 AET39269.1 - 1.1e-07 32.4 1.8 1.1e-07 32.4 1.8 2.2 2 0 0 2 2 2 1 HMG-box domain AP3D1 PF06375.11 AET39269.1 - 0.00035 20.9 5.7 0.00035 20.9 5.7 1.7 1 1 0 1 1 1 1 AP-3 complex subunit delta-1 Transketolase_N PF00456.21 AET39269.1 - 0.15 11.0 0.4 0.21 10.5 0.4 1.2 1 0 0 1 1 1 0 Transketolase, thiamine diphosphate binding domain Zip PF02535.22 AET39270.1 - 4.1e-71 239.9 10.1 5.3e-71 239.6 10.1 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF4728 PF15860.5 AET39270.1 - 3.4 8.4 0.0 3.4 8.4 0.0 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4728) IPK PF03770.16 AET39271.1 - 2.2e-55 187.6 1.3 2.9e-55 187.2 1.3 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase HSP20 PF00011.21 AET39272.1 - 6.5e-11 42.3 0.0 1.1e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 AET39272.1 - 0.00014 21.4 0.0 0.00034 20.1 0.0 1.7 2 0 0 2 2 2 1 HSP20-like domain found in ArsA Sec7 PF01369.20 AET39273.1 - 1.4e-66 223.7 0.3 4.8e-66 221.9 0.3 2.0 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 AET39273.1 - 3.4e-42 144.0 1.1 3.4e-42 144.0 1.1 3.8 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 AET39273.1 - 8.6e-29 99.2 6.1 2.5e-27 94.6 0.3 4.8 4 0 0 4 4 4 1 Domain of unknown function (DUF1981) DCB PF16213.5 AET39273.1 - 3.6e-15 56.1 13.6 9.9e-15 54.7 1.5 3.9 4 0 0 4 4 4 2 Dimerisation and cyclophilin-binding domain of Mon2 AMP-binding PF00501.28 AET39274.1 - 7.4e-84 281.8 0.0 9.2e-84 281.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AET39274.1 - 8.5e-25 87.5 0.3 1.9e-24 86.4 0.3 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 AET39274.1 - 2.5e-20 72.1 0.5 5.1e-20 71.2 0.5 1.6 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Mem_trans PF03547.18 AET39275.1 - 4e-33 114.4 0.0 6.1e-33 113.8 0.0 1.3 1 1 0 1 1 1 1 Membrane transport protein DUF3481 PF11980.8 AET39275.1 - 0.063 13.0 0.1 0.17 11.6 0.1 1.7 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein Dicty_REP PF05086.12 AET39275.1 - 0.26 9.2 2.4 0.39 8.6 2.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein NUDIX PF00293.28 AET39276.1 - 2.9e-13 50.0 0.0 5.2e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Stm1_N PF09598.10 AET39277.1 - 2.1e-10 41.3 5.3 2.1e-10 41.3 5.3 4.7 4 1 1 5 5 5 2 Stm1 HABP4_PAI-RBP1 PF04774.15 AET39277.1 - 0.0014 19.5 6.7 0.0014 19.5 6.7 2.6 3 0 0 3 3 3 1 Hyaluronan / mRNA binding family Stb3 PF10330.9 AET39278.1 - 4.1e-30 103.7 0.1 8.1e-30 102.7 0.1 1.5 1 0 0 1 1 1 1 Putative Sin3 binding protein TFIIA PF03153.13 AET39278.1 - 0.006 16.6 1.2 0.006 16.6 1.2 2.3 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Cwf_Cwc_15 PF04889.12 AET39278.1 - 0.033 13.9 8.3 0.077 12.7 8.3 1.6 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.11 AET39278.1 - 0.12 12.4 5.1 0.33 11.0 5.1 1.8 1 0 0 1 1 1 0 RXT2-like, N-terminal FAM176 PF14851.6 AET39278.1 - 0.28 10.9 4.3 0.65 9.6 4.3 1.7 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 AET39278.1 - 0.52 9.6 9.7 0.85 8.9 9.7 1.3 1 0 0 1 1 1 0 NOA36 protein RNA_pol_3_Rpc31 PF11705.8 AET39278.1 - 1.1 9.5 11.7 1.1 9.5 9.6 2.0 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 DUF2415 PF10313.9 AET39279.1 - 1.6e-20 72.8 1.5 3e-20 71.8 1.5 1.5 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) CDC37_N PF03234.14 AET39280.1 - 5e-44 150.3 7.7 5e-44 150.3 7.7 3.8 3 1 1 4 4 4 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 AET39280.1 - 6.2e-42 142.3 1.9 6.2e-42 142.3 1.9 2.2 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 AET39280.1 - 3.1e-32 110.7 6.4 3.1e-32 110.7 6.4 2.6 2 1 1 3 3 3 1 Cdc37 C terminal domain MPM1 PF17234.2 AET39280.1 - 0.046 14.0 0.8 0.046 14.0 0.8 3.4 3 1 0 3 3 3 0 Mitochondrial peculiar membrane protein 1 SAP30_Sin3_bdg PF13867.6 AET39280.1 - 0.048 14.0 0.3 0.56 10.6 0.0 2.7 2 0 0 2 2 2 0 Sin3 binding region of histone deacetylase complex subunit SAP30 HrpB_C PF08482.10 AET39280.1 - 0.52 10.7 0.1 0.52 10.7 0.1 2.6 4 0 0 4 4 4 0 ATP-dependent helicase C-terminal TFIID_30kDa PF03540.13 AET39281.1 - 6.8e-25 86.8 0.0 1.2e-24 86.0 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Formyl_trans_N PF00551.19 AET39281.1 - 0.11 12.2 0.2 1.1 8.9 0.0 2.0 2 0 0 2 2 2 0 Formyl transferase CBFD_NFYB_HMF PF00808.23 AET39281.1 - 0.13 12.6 0.1 1.8 8.9 0.0 2.5 2 1 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Pep3_Vps18 PF05131.14 AET39282.1 - 1.9e-34 118.6 0.0 5.4e-34 117.2 0.0 1.9 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 AET39282.1 - 3.5e-08 33.4 2.5 3.5e-08 33.4 2.5 4.2 2 2 3 5 5 5 1 Region in Clathrin and VPS zf-RING_UBOX PF13445.6 AET39282.1 - 8.9e-05 22.4 0.8 0.00019 21.4 0.8 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 AET39282.1 - 0.00024 21.0 1.1 0.00024 21.0 1.1 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 AET39282.1 - 0.00031 21.0 1.7 0.00031 21.0 1.7 2.0 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 AET39282.1 - 0.0011 18.8 1.7 0.0011 18.8 1.7 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Vps39_2 PF10367.9 AET39282.1 - 0.002 18.5 3.3 0.0022 18.4 0.2 2.6 2 1 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 zf-C3H2C3 PF17122.5 AET39282.1 - 0.0025 17.8 1.0 0.005 16.9 1.0 1.5 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4 PF00097.25 AET39282.1 - 0.005 16.7 1.8 0.016 15.0 1.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 AET39282.1 - 0.0058 16.3 4.2 0.021 14.6 4.2 2.0 1 0 0 1 1 1 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 AET39282.1 - 0.084 12.5 0.2 0.084 12.5 0.2 2.1 3 0 0 3 3 2 0 Zinc-ribbon, C4HC2 type LSM PF01423.22 AET39283.1 - 4.9e-17 61.4 0.1 5.8e-17 61.1 0.1 1.1 1 0 0 1 1 1 1 LSM domain Tail_tube PF10618.9 AET39283.1 - 0.0022 17.9 0.1 0.06 13.2 0.0 2.0 1 1 1 2 2 2 1 Phage tail tube protein SM-ATX PF14438.6 AET39283.1 - 0.05 13.8 0.0 0.071 13.3 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Sec5 PF15469.6 AET39284.1 - 3.7e-55 186.7 8.5 3.7e-55 186.7 8.5 3.3 5 0 0 5 5 5 1 Exocyst complex component Sec5 Tudor-knot PF11717.8 AET39284.1 - 0.15 12.0 0.9 1.5 8.7 0.0 2.6 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain zf-CRD PF17979.1 AET39284.1 - 6.1 6.9 8.6 1.3 9.1 0.0 3.7 3 2 1 5 5 5 0 Cysteine rich domain with multizinc binding regions WD40 PF00400.32 AET39285.1 - 0.0037 18.1 0.9 3.8 8.5 0.4 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat DUF4477 PF14780.6 AET39286.1 - 0.11 12.1 2.9 6.2 6.4 0.1 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4477) Glyco_hydro81C PF17652.1 AET39287.1 - 5.2e-150 499.5 4.5 6.5e-150 499.2 4.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 AET39287.1 - 2.7e-95 319.3 3.3 3.7e-95 318.8 3.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain DUF11 PF01345.18 AET39287.1 - 0.041 14.2 1.2 0.17 12.2 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF11 Sec1 PF00995.23 AET39288.1 - 6.3e-91 306.3 6.2 7.5e-91 306.1 6.2 1.0 1 0 0 1 1 1 1 Sec1 family Diphthami_syn_2 PF01902.17 AET39290.1 - 1.4e-35 122.8 0.0 1.2e-34 119.8 0.0 2.3 1 1 0 1 1 1 1 Diphthamide synthase Ribonuc_L-PSP PF01042.21 AET39290.1 - 1.5e-13 50.8 0.0 1.8e-08 34.4 0.0 2.8 2 1 0 2 2 2 2 Endoribonuclease L-PSP Pro_dh PF01619.18 AET39291.1 - 4.5e-58 197.1 0.0 5.6e-58 196.8 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase LD_cluster2 PF18163.1 AET39291.1 - 0.13 11.7 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 SLOG cluster2 SLS PF14611.6 AET39293.1 - 3e-47 161.3 1.5 3e-47 161.3 1.5 1.8 2 0 0 2 2 2 1 Mitochondrial inner-membrane-bound regulator SAP30_Sin3_bdg PF13867.6 AET39293.1 - 0.015 15.6 0.0 0.037 14.3 0.0 1.7 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 RPW8 PF05659.11 AET39293.1 - 0.31 10.7 5.1 0.96 9.1 5.1 1.8 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Cwf_Cwc_15 PF04889.12 AET39294.1 - 9.7e-20 71.3 8.6 1.8e-12 47.5 0.6 2.0 1 1 1 2 2 2 2 Cwf15/Cwc15 cell cycle control protein SH3_1 PF00018.28 AET39295.1 - 4.6e-14 51.7 0.1 1.1e-13 50.6 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AET39295.1 - 1.1e-13 50.7 0.2 2.4e-13 49.7 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AET39295.1 - 1.3e-09 37.6 0.1 3.1e-09 36.4 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain TPR_8 PF13181.6 AET39296.1 - 2.3e-09 36.7 0.3 0.0061 16.7 0.0 4.0 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 AET39296.1 - 1.2e-08 34.4 0.0 0.011 15.8 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 AET39296.1 - 5.5e-08 32.3 0.1 0.016 15.0 0.0 3.6 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 AET39296.1 - 4.3e-07 30.2 0.1 0.027 15.3 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 AET39296.1 - 4.4e-07 30.3 0.5 0.0015 19.0 0.5 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 AET39296.1 - 6.6e-07 28.9 1.7 0.031 14.0 0.2 4.2 4 0 0 4 4 4 2 TPR repeat TPR_17 PF13431.6 AET39296.1 - 0.00019 21.6 0.4 0.081 13.3 0.2 3.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 AET39296.1 - 0.00079 19.7 0.2 1.5 9.1 0.0 3.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 AET39296.1 - 0.00082 19.2 0.0 0.058 13.4 0.0 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AET39296.1 - 0.001 19.2 0.3 0.1 12.8 0.1 3.2 3 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 SNAP PF14938.6 AET39296.1 - 0.011 15.2 0.2 0.36 10.2 0.1 2.1 2 0 0 2 2 2 0 Soluble NSF attachment protein, SNAP TPR_15 PF13429.6 AET39296.1 - 0.023 13.9 0.4 1.2 8.2 0.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat RcsC PF09456.10 AET39296.1 - 0.093 12.7 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 RcsC Alpha-Beta-Loop (ABL) AA_permease PF00324.21 AET39297.1 - 7.1e-74 249.1 46.2 4.3e-73 246.5 46.2 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AET39297.1 - 9.1e-31 107.1 45.1 3.8e-30 105.1 45.1 1.8 1 1 0 1 1 1 1 Amino acid permease Na_H_Exchanger PF00999.21 AET39298.1 - 4.8e-87 292.2 24.8 5.8e-87 292.0 24.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Nha1_C PF08619.10 AET39298.1 - 8.5e-64 216.5 25.8 8.5e-57 193.4 16.3 2.1 1 1 1 2 2 2 2 Alkali metal cation/H+ antiporter Nha1 C terminus YrhC PF14143.6 AET39298.1 - 0.19 11.8 0.2 0.75 9.9 0.2 2.0 1 0 0 1 1 1 0 YrhC-like protein SAC3_GANP PF03399.16 AET39299.1 - 1.8e-100 336.1 1.2 3.4e-100 335.2 1.2 1.5 1 0 0 1 1 1 1 SAC3/GANP family SAC3 PF12209.8 AET39299.1 - 3.9e-21 75.0 1.1 1.5e-20 73.1 1.1 2.1 1 0 0 1 1 1 1 Leucine permease transcriptional regulator helical domain KIP1 PF07765.12 AET39299.1 - 5.5 7.2 6.7 0.67 10.1 0.4 2.9 3 0 0 3 3 3 0 KIP1-like protein Methyltransf_16 PF10294.9 AET39300.1 - 1.7e-06 27.9 1.4 0.0081 15.9 0.2 2.4 1 1 1 2 2 2 2 Lysine methyltransferase Enkurin PF13864.6 AET39300.1 - 0.0095 16.4 0.2 0.022 15.2 0.2 1.5 1 0 0 1 1 1 1 Calmodulin-binding Semialdhyde_dhC PF02774.18 AET39301.1 - 4.6e-45 154.0 0.0 6.6e-45 153.5 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 AET39301.1 - 1.3e-31 109.5 0.0 2.4e-31 108.7 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 AET39301.1 - 0.019 15.2 0.0 0.037 14.3 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DXP_reductoisom PF02670.16 AET39301.1 - 0.069 13.9 0.1 0.28 11.9 0.0 2.0 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase RNA_polI_A14 PF08203.11 AET39302.1 - 4.2e-24 85.1 0.0 9e-24 84.0 0.0 1.5 1 0 0 1 1 1 1 Yeast RNA polymerase I subunit RPA14 Pro_isomerase PF00160.21 AET39303.1 - 2.1e-48 164.6 0.1 2.4e-48 164.4 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rgp1 PF08737.10 AET39304.1 - 2.7e-90 303.6 6.0 2.7e-90 303.6 6.0 1.4 2 0 0 2 2 2 1 Rgp1 Avl9 PF09794.9 AET39305.1 - 2.4e-148 493.9 1.3 2.9e-148 493.6 1.3 1.1 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.10 AET39305.1 - 1.1e-09 38.2 0.1 0.00014 21.8 0.0 2.7 3 0 0 3 3 3 2 Stabilization of polarity axis DUF2347 PF09804.9 AET39305.1 - 7.2e-09 35.6 0.2 6.1e-07 29.3 0.2 2.6 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) Afi1 PF07792.12 AET39305.1 - 0.00071 20.1 0.7 0.0016 18.9 0.0 1.9 2 0 0 2 2 2 1 Docking domain of Afi1 for Arf3 in vesicle trafficking DENN PF02141.21 AET39305.1 - 0.002 18.1 2.1 0.21 11.5 0.9 2.9 2 1 0 2 2 2 1 DENN (AEX-3) domain efThoc1 PF11957.8 AET39306.1 - 1.6e-106 356.9 18.8 1.6e-106 356.9 18.8 1.6 1 1 1 2 2 2 1 THO complex subunit 1 transcription elongation factor SF3a60_bindingd PF12108.8 AET39306.1 - 1.2 9.1 4.7 7.6 6.5 1.2 2.9 2 0 0 2 2 2 0 Splicing factor SF3a60 binding domain SF1-HH PF16275.5 AET39307.1 - 6.2e-41 139.3 1.9 1.2e-40 138.4 1.9 1.5 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain zf-CCHC PF00098.23 AET39307.1 - 1.3e-08 34.5 9.7 2.2e-06 27.5 0.7 2.3 2 0 0 2 2 2 2 Zinc knuckle KH_1 PF00013.29 AET39307.1 - 4.6e-07 29.6 0.1 9.7e-07 28.5 0.1 1.5 1 0 0 1 1 1 1 KH domain zf-CCHC_3 PF13917.6 AET39307.1 - 0.0004 20.3 5.7 0.017 15.1 0.4 2.5 2 0 0 2 2 2 2 Zinc knuckle UPF0167 PF03691.14 AET39307.1 - 0.026 14.3 0.2 0.041 13.7 0.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) zf-CCHC_4 PF14392.6 AET39307.1 - 0.045 13.5 2.8 1.3 8.8 0.4 2.3 2 0 0 2 2 2 0 Zinc knuckle Lar_restr_allev PF14354.6 AET39307.1 - 0.15 12.5 4.2 0.27 11.6 4.2 1.4 1 0 0 1 1 1 0 Restriction alleviation protein Lar Prim_Zn_Ribbon PF08273.12 AET39307.1 - 0.57 10.5 3.6 1.1 9.7 3.6 1.4 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase zf-CCHC_2 PF13696.6 AET39307.1 - 1.9 8.4 13.3 0.68 9.8 1.2 2.5 2 0 0 2 2 2 0 Zinc knuckle HAT PF02184.16 AET39308.1 - 1.1e-17 63.7 29.8 1e-05 25.3 0.0 9.4 9 1 0 9 9 9 4 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 AET39308.1 - 4.6e-16 58.1 0.1 0.063 14.1 0.0 9.0 4 2 7 11 11 11 5 Tetratricopeptide repeat Suf PF05843.14 AET39308.1 - 5.5e-14 52.8 24.8 0.0021 18.1 0.0 7.4 2 2 4 6 6 6 3 Suppressor of forked protein (Suf) TPR_19 PF14559.6 AET39308.1 - 6.6e-08 33.0 0.0 0.0022 18.4 0.0 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 AET39308.1 - 0.00073 19.7 5.3 0.017 15.5 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 AET39308.1 - 0.0028 17.6 4.3 30 5.1 0.0 6.4 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_16 PF13432.6 AET39308.1 - 0.027 15.1 0.1 2 9.1 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Babuvirus_MP PF07234.11 AET39308.1 - 0.076 13.2 0.8 4.1 7.6 0.0 3.1 3 0 0 3 3 3 0 Movement and RNA silencing protein U3_assoc_6 PF08640.11 AET39308.1 - 3.1 7.9 23.8 0.029 14.4 2.1 5.3 4 2 2 6 6 6 0 U3 small nucleolar RNA-associated protein 6 ubiquitin PF00240.23 AET39309.1 - 6e-17 61.2 0.1 6.5e-17 61.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 AET39309.1 - 1.8e-09 37.3 0.0 1.9e-09 37.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 AET39309.1 - 0.0015 18.4 0.0 0.0015 18.4 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 AET39309.1 - 0.015 15.7 0.0 0.015 15.7 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin-like domain MTS PF05175.14 AET39310.1 - 3.1e-06 26.9 0.0 4.9e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain DUF938 PF06080.12 AET39310.1 - 0.0034 17.2 0.0 0.0055 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF938) PrmA PF06325.13 AET39310.1 - 0.062 12.7 0.0 0.091 12.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 AET39310.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_23 PF13489.6 AET39310.1 - 0.15 11.9 0.0 0.32 10.8 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Dopey_N PF04118.14 AET39311.1 - 2.1e-112 375.2 2.3 2.1e-112 375.2 2.3 3.1 3 1 0 3 3 3 1 Dopey, N-terminal Abhydrolase_2 PF02230.16 AET39312.1 - 1.6e-54 185.0 0.0 1.8e-54 184.9 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 AET39312.1 - 1.1e-08 35.0 0.0 2.3e-08 34.0 0.0 1.5 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 AET39312.1 - 7e-07 29.0 0.0 7.2e-06 25.7 0.0 1.9 2 0 0 2 2 2 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 AET39312.1 - 2.1e-06 27.2 0.0 0.0024 17.2 0.0 2.9 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 AET39312.1 - 4.2e-06 27.5 0.0 4.7e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 AET39312.1 - 0.0012 18.5 0.2 0.0074 16.0 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 AET39312.1 - 0.01 15.4 0.0 0.94 8.9 0.0 2.6 2 1 1 3 3 3 0 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 AET39312.1 - 0.013 15.3 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2974 PF11187.8 AET39312.1 - 0.15 11.6 0.0 0.29 10.7 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Mod_r PF07200.13 AET39313.1 - 4.7e-21 75.4 10.7 6.5e-21 75.0 10.7 1.2 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein FapA PF03961.13 AET39313.1 - 0.45 9.1 4.1 0.44 9.1 1.2 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A DHR10 PF18595.1 AET39313.1 - 0.47 10.5 5.3 6.1 6.9 0.2 2.4 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain PCRF PF03462.18 AET39313.1 - 1.6 8.5 5.3 3.7 7.4 1.8 2.0 1 1 1 2 2 2 0 PCRF domain WD40 PF00400.32 AET39314.1 - 1.9e-14 53.8 11.7 0.0037 18.1 0.1 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat zf-RING_2 PF13639.6 AET39315.1 - 2.5e-10 40.5 9.9 6.9e-09 35.9 5.7 2.3 2 0 0 2 2 2 2 Ring finger domain zf-rbx1 PF12678.7 AET39315.1 - 7.8e-08 32.5 6.1 2.3e-07 31.0 4.0 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 AET39315.1 - 2.4e-06 27.3 2.7 2.4e-06 27.3 2.7 1.8 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 AET39315.1 - 7.2e-05 22.5 9.9 7.9e-05 22.4 5.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AET39315.1 - 0.00012 21.9 7.9 0.00014 21.7 4.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AET39315.1 - 0.00013 21.9 9.6 0.00051 20.0 3.4 2.8 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 AET39315.1 - 0.0002 21.2 6.1 0.00034 20.4 3.4 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 AET39315.1 - 0.00032 20.8 3.5 0.00032 20.8 3.5 1.7 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 AET39315.1 - 0.0037 17.2 7.1 0.015 15.2 3.9 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 AET39315.1 - 0.007 16.1 6.4 0.15 11.8 0.6 3.0 3 0 0 3 3 3 2 RING-like zinc finger zf-ANAPC11 PF12861.7 AET39315.1 - 0.022 14.8 3.2 0.045 13.8 0.9 2.5 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 AET39315.1 - 2.1 8.2 7.7 1.5 8.6 3.3 2.2 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Asp PF00026.23 AET39316.1 - 5.3e-70 236.3 0.3 6.8e-70 236.0 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AET39316.1 - 1.8e-11 44.6 0.1 3.7e-11 43.6 0.1 1.6 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 AET39316.1 - 0.0077 16.9 0.9 18 6.0 0.0 3.6 3 0 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 AET39316.1 - 0.011 16.3 0.1 11 6.6 0.0 3.6 3 1 0 3 3 3 0 gag-polyprotein putative aspartyl protease RPA_C PF08784.11 AET39317.1 - 0.053 14.2 0.0 0.13 12.9 0.0 1.7 1 0 0 1 1 1 0 Replication protein A C terminal Cullin_binding PF03556.15 AET39318.1 - 9.9e-30 103.5 3.5 9.9e-30 103.5 3.5 1.9 2 1 1 3 3 3 1 Cullin binding UBA_4 PF14555.6 AET39318.1 - 2.8e-08 33.5 0.0 5.6e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 AET39318.1 - 0.00053 19.6 0.1 0.0013 18.3 0.1 1.6 1 0 0 1 1 1 1 TAP C-terminal domain TFIID_20kDa PF03847.13 AET39319.1 - 3.3e-32 110.8 2.4 3.9e-32 110.6 0.6 2.0 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A TFIID-31kDa PF02291.15 AET39319.1 - 0.0015 18.6 0.0 0.0074 16.3 0.0 2.2 2 0 0 2 2 2 1 Transcription initiation factor IID, 31kD subunit Syntaxin PF00804.25 AET39319.1 - 0.0075 16.0 4.8 0.0075 16.0 4.8 2.0 2 0 0 2 2 2 1 Syntaxin Histone PF00125.24 AET39319.1 - 0.0086 16.4 0.0 0.0086 16.4 0.0 3.7 3 1 0 4 4 4 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AET39319.1 - 0.06 13.6 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Fzo_mitofusin PF04799.13 AET39319.1 - 1 8.9 4.7 1.8 8.1 4.1 1.7 1 1 0 1 1 1 0 fzo-like conserved region FapA PF03961.13 AET39319.1 - 3.7 6.1 9.1 7 5.1 9.1 1.5 1 0 0 1 1 1 0 Flagellar Assembly Protein A WD40 PF00400.32 AET39320.1 - 9.5e-53 175.0 26.7 1.7e-06 28.6 0.2 11.5 11 0 0 11 11 11 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET39320.1 - 6.4e-21 74.5 7.6 0.00082 19.6 0.0 8.6 3 2 6 9 9 9 6 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 AET39320.1 - 7.5e-18 64.8 0.2 1.6e-17 63.8 0.2 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40_like PF17005.5 AET39320.1 - 2.3e-10 40.3 3.1 0.0011 18.4 0.2 4.0 3 1 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 AET39320.1 - 2.3e-07 29.9 8.5 0.0028 16.4 0.0 5.3 5 2 2 7 7 7 3 Nucleoporin Nup120/160 eIF2A PF08662.11 AET39320.1 - 1.9e-05 24.6 3.6 3.9 7.3 0.0 5.4 3 2 2 5 5 5 2 Eukaryotic translation initiation factor eIF2A Hira PF07569.11 AET39320.1 - 0.00011 22.0 9.2 0.73 9.5 0.0 5.1 5 0 0 5 5 5 2 TUP1-like enhancer of split ELYS-bb PF16687.5 AET39320.1 - 0.0074 14.9 0.0 0.066 11.8 0.0 2.3 2 0 0 2 2 2 1 beta-propeller of ELYS nucleoporin PALB2_WD40 PF16756.5 AET39320.1 - 0.028 13.4 9.6 1.2 8.0 0.0 4.7 4 2 2 6 6 6 0 Partner and localizer of BRCA2 WD40 domain HVSL PF09749.9 AET39321.1 - 2.8e-24 85.9 3.0 3.8e-24 85.5 3.0 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein TFIIE_beta PF02186.15 AET39321.1 - 0.013 15.8 0.1 0.035 14.4 0.1 1.8 1 0 0 1 1 1 0 TFIIE beta subunit core domain Choline_kinase PF01633.20 AET39322.1 - 1.2e-61 208.0 0.0 1.7e-61 207.5 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.14 AET39322.1 - 1.4e-12 47.1 0.3 3.7e-12 45.7 0.1 1.8 2 0 0 2 2 2 1 Choline kinase N terminus APH PF01636.23 AET39322.1 - 5.2e-08 33.1 0.0 0.00052 20.0 0.0 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family 2-oxoacid_dh PF00198.23 AET39323.1 - 1.9e-78 263.1 0.1 2.5e-78 262.7 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 AET39323.1 - 4.4e-15 55.3 0.2 8.1e-15 54.4 0.2 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme HlyD_3 PF13437.6 AET39323.1 - 2.5e-05 24.9 0.2 0.0024 18.5 0.0 2.5 1 1 1 2 2 2 1 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 AET39323.1 - 0.00012 21.8 0.1 0.0047 16.7 0.0 2.4 1 1 1 2 2 2 1 Biotin-lipoyl like GCV_H PF01597.19 AET39323.1 - 0.00034 20.5 0.1 0.00073 19.4 0.1 1.6 1 0 0 1 1 1 1 Glycine cleavage H-protein HlyD_D23 PF16576.5 AET39323.1 - 0.023 13.9 0.5 0.1 11.8 0.0 2.1 2 1 1 3 3 3 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion RnfC_N PF13375.6 AET39323.1 - 0.036 14.0 0.0 0.14 12.1 0.0 1.9 1 1 1 2 2 2 0 RnfC Barrel sandwich hybrid domain Slx4 PF09494.10 AET39324.1 - 5.9e-13 48.6 0.0 1.6e-12 47.2 0.0 1.8 1 0 0 1 1 1 1 Slx4 endonuclease Mcp5_PH PF12814.7 AET39325.1 - 4.4e-41 139.8 0.2 1.6e-40 138.0 0.0 2.2 2 0 0 2 2 2 1 Meiotic cell cortex C-terminal pleckstrin homology PH_2 PF08458.10 AET39325.1 - 0.1 13.0 0.0 0.44 10.9 0.0 2.2 1 0 0 1 1 1 0 Plant pleckstrin homology-like region bZIP_1 PF00170.21 AET39325.1 - 0.29 11.2 25.9 0.031 14.4 2.8 5.3 2 1 0 3 3 3 0 bZIP transcription factor AMP-binding_C_2 PF14535.6 AET39325.1 - 0.95 9.8 7.7 1.3 9.3 0.8 4.4 4 0 0 4 4 4 0 AMP-binding enzyme C-terminal domain NPV_P10 PF05531.12 AET39325.1 - 1.6 9.2 11.8 3.1 8.3 1.0 5.0 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4472 PF14739.6 AET39325.1 - 2.6 8.8 22.3 0.29 11.9 2.7 4.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) DUF3450 PF11932.8 AET39325.1 - 4.2 6.6 22.7 0.95 8.7 2.5 3.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) ADIP PF11559.8 AET39325.1 - 5.1 7.2 37.6 0.0054 16.8 11.8 4.7 2 1 4 6 6 6 0 Afadin- and alpha -actinin-Binding TPR_MLP1_2 PF07926.12 AET39325.1 - 7.4 6.7 42.2 0.28 11.3 16.1 5.1 2 1 0 4 4 4 0 TPR/MLP1/MLP2-like protein Noelin-1 PF12308.8 AET39325.1 - 10 6.2 7.5 4.1 7.4 2.6 3.1 2 0 0 2 2 2 0 Neurogenesis glycoprotein zf-CCCH PF00642.24 AET39326.1 - 2.2e-17 62.5 17.9 1.1e-08 34.7 2.2 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AET39326.1 - 1.1e-05 25.3 20.3 0.00038 20.4 2.9 2.4 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 AET39326.1 - 0.017 14.9 14.1 0.48 10.3 7.0 2.4 2 0 0 2 2 2 0 CCCH-type zinc finger zf-CCCH_2 PF14608.6 AET39326.1 - 0.13 12.8 13.3 2.1 8.9 0.8 2.3 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Torus PF16131.5 AET39326.1 - 0.85 10.3 13.2 0.82 10.4 2.5 2.4 1 1 1 2 2 2 0 Torus domain RWD PF05773.22 AET39327.1 - 2.1e-24 86.0 1.9 3.8e-24 85.2 1.9 1.4 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.5 AET39327.1 - 0.00027 21.4 1.2 0.00027 21.4 1.2 2.1 2 1 1 3 3 3 1 DRG Family Regulatory Proteins, Tma46 DUF4207 PF13904.6 AET39327.1 - 0.0012 18.6 0.7 0.0017 18.1 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) ENTH PF01417.20 AET39328.1 - 2.9e-31 108.1 0.4 4.7e-31 107.4 0.4 1.3 1 0 0 1 1 1 1 ENTH domain DSS1_SEM1 PF05160.13 AET39328.1 - 0.018 15.1 0.7 5.1 7.2 0.1 2.5 2 0 0 2 2 2 0 DSS1/SEM1 family ABC_membrane PF00664.23 AET39329.1 - 2.2e-90 303.0 52.6 1.2e-52 179.3 19.3 3.2 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 AET39329.1 - 6.8e-48 162.7 0.0 2.3e-28 99.4 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 AET39329.1 - 8.9e-10 38.4 5.8 0.00063 19.2 0.1 4.2 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 AET39329.1 - 6.8e-06 26.1 0.5 0.14 12.3 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 AET39329.1 - 0.00013 21.6 0.1 0.44 10.3 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AET39329.1 - 0.00031 20.7 0.0 0.26 11.2 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_7 PF12775.7 AET39329.1 - 0.0076 15.8 0.1 2.1 7.8 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region DUF87 PF01935.17 AET39329.1 - 0.012 15.7 4.1 0.061 13.4 0.0 2.9 3 0 0 3 3 3 0 Helicase HerA, central domain IstB_IS21 PF01695.17 AET39329.1 - 0.012 15.3 1.0 10 5.8 0.0 3.6 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_21 PF13304.6 AET39329.1 - 0.014 15.3 0.5 0.91 9.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 AET39329.1 - 0.018 15.5 0.0 8.5 6.7 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 AET39329.1 - 0.024 14.9 1.1 4.3 7.6 0.1 3.2 2 1 0 2 2 2 0 AAA domain Roc PF08477.13 AET39329.1 - 0.029 14.6 0.9 4 7.7 0.0 3.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TrwB_AAD_bind PF10412.9 AET39329.1 - 0.041 12.8 0.3 1.1 8.1 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain HTH_45 PF14947.6 AET39329.1 - 0.044 13.8 0.1 0.2 11.7 0.1 2.2 2 0 0 2 2 1 0 Winged helix-turn-helix AAA_30 PF13604.6 AET39329.1 - 0.07 12.8 0.5 15 5.2 0.1 3.0 3 0 0 3 3 3 0 AAA domain AAA_10 PF12846.7 AET39329.1 - 0.072 12.0 0.3 8.2 5.2 0.0 3.3 3 0 0 3 3 3 0 AAA-like domain RNA_helicase PF00910.22 AET39329.1 - 0.11 12.9 0.0 12 6.4 0.0 2.7 2 0 0 2 2 2 0 RNA helicase MeaB PF03308.16 AET39329.1 - 0.13 11.2 0.0 14 4.5 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 AET39329.1 - 0.14 11.8 0.0 14 5.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 AET39329.1 - 0.51 10.8 0.0 0.51 10.8 0.0 3.3 5 0 0 5 5 3 0 AAA domain AIG1 PF04548.16 AET39329.1 - 2.4 7.4 4.6 6.5 6.0 0.0 2.9 3 0 0 3 3 3 0 AIG1 family Pkinase PF00069.25 AET39330.1 - 3.5e-67 226.5 0.1 8.4e-67 225.3 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET39330.1 - 2.9e-31 108.7 0.0 5.2e-31 107.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AET39330.1 - 3.2e-06 26.3 0.1 5.4e-06 25.6 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 AET39330.1 - 0.00017 21.0 0.2 0.00068 19.1 0.2 1.9 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AET39330.1 - 0.0014 18.6 5.1 0.0017 18.4 0.0 2.5 2 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 AET39330.1 - 0.036 13.6 0.0 0.087 12.4 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Neur_chan_memb PF02932.16 AET39330.1 - 0.066 13.3 1.8 0.081 13.0 1.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FTA2 PF13095.6 AET39330.1 - 0.077 12.6 0.0 0.077 12.6 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 SRP-alpha_N PF04086.13 AET39330.1 - 0.12 12.3 11.8 0.17 11.8 11.8 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal eIF-3_zeta PF05091.12 AET39330.1 - 0.2 10.6 10.6 0.26 10.2 10.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Pkinase_fungal PF17667.1 AET39330.1 - 0.25 10.1 7.4 0.42 9.3 0.0 2.1 2 0 0 2 2 2 0 Fungal protein kinase RR_TM4-6 PF06459.12 AET39330.1 - 0.35 10.6 10.8 0.5 10.2 10.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 VIR_N PF15912.5 AET39330.1 - 1.7 8.1 12.2 2.6 7.6 12.2 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal Rtf2 PF04641.12 AET39330.1 - 3.4 7.0 12.1 5.9 6.2 12.1 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger Presenilin PF01080.17 AET39330.1 - 3.6 6.2 15.3 5 5.8 15.3 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 AET39330.1 - 3.7 5.7 11.4 5.1 5.3 11.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Spt20 PF12090.8 AET39330.1 - 6.7 6.2 28.5 11 5.5 28.5 1.3 1 0 0 1 1 1 0 Spt20 family Med19 PF10278.9 AET39330.1 - 6.8 6.6 10.6 12 5.8 10.6 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Flocculin_t3 PF13928.6 AET39333.1 - 1.4e-12 47.9 18.4 1.4e-12 47.9 18.4 2.9 3 0 0 3 3 3 1 Flocculin type 3 repeat BTB_2 PF02214.22 AET39334.1 - 3.8e-08 33.6 0.0 0.00089 19.6 0.0 2.7 2 1 0 2 2 2 2 BTB/POZ domain FIN1 PF17300.2 AET39335.1 - 3e-70 236.5 15.0 3.5e-70 236.3 15.0 1.0 1 0 0 1 1 1 1 Filaments in between nuclei protein-1 EloA-BP1 PF15870.5 AET39336.1 - 0.015 15.6 1.1 5.8 7.1 0.3 2.3 1 1 1 2 2 2 0 ElonginA binding-protein 1 KIX_2 PF16987.5 AET39336.1 - 0.016 15.1 0.1 0.04 13.9 0.1 1.6 1 0 0 1 1 1 0 KIX domain CHORD PF04968.12 AET39336.1 - 0.017 15.9 3.4 0.043 14.5 3.4 1.7 1 0 0 1 1 1 0 CHORD DNA_pol_A_exo1 PF01612.20 AET39336.1 - 0.073 12.8 0.2 0.65 9.7 0.1 2.6 2 1 0 2 2 2 0 3'-5' exonuclease AAA_5 PF07728.14 AET39337.1 - 2.1e-125 413.2 1.2 7.9e-22 77.7 0.0 10.3 10 0 0 10 10 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 AET39337.1 - 3.6e-53 178.3 1.0 5.4e-21 74.8 0.0 5.1 4 0 0 4 4 4 3 Midasin AAA lid domain AAA_lid_5 PF17865.1 AET39337.1 - 4.1e-33 113.6 0.0 2.6e-30 104.6 0.0 4.3 3 0 0 3 3 2 1 Midasin AAA lid domain AAA_7 PF12775.7 AET39337.1 - 4.8e-32 110.9 13.0 3.5e-08 33.2 0.1 7.4 7 0 0 7 7 7 6 P-loop containing dynein motor region AAA_3 PF07726.11 AET39337.1 - 6.5e-32 110.1 0.0 6.4e-10 39.0 0.0 7.7 7 0 0 7 7 7 3 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 AET39337.1 - 3.5e-29 101.9 0.4 0.00035 21.0 0.1 7.3 6 0 0 6 6 6 6 ATPase family associated with various cellular activities (AAA) AAA_6 PF12774.7 AET39337.1 - 1.8e-23 83.0 3.0 0.0053 15.8 0.0 9.6 9 1 0 9 9 9 5 Hydrolytic ATP binding site of dynein motor region Dynein_heavy PF03028.15 AET39337.1 - 3.8e-22 78.6 0.0 5.4e-05 23.3 0.0 8.1 7 1 0 7 7 7 3 Dynein heavy chain region D6 P-loop domain Sigma54_activat PF00158.26 AET39337.1 - 4.8e-20 71.9 0.7 0.0024 17.6 0.1 6.4 7 0 0 7 7 6 3 Sigma-54 interaction domain AAA_16 PF13191.6 AET39337.1 - 1.3e-19 71.2 11.4 0.00074 19.9 0.1 8.4 6 2 0 6 6 6 4 AAA ATPase domain AAA_30 PF13604.6 AET39337.1 - 1.3e-17 64.1 0.0 0.037 13.7 0.1 7.7 7 1 0 7 7 7 3 AAA domain TsaE PF02367.17 AET39337.1 - 5e-16 58.8 2.1 0.092 12.7 0.1 6.8 6 0 0 6 6 6 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 AET39337.1 - 2.6e-15 56.9 0.2 0.045 14.0 0.0 7.4 6 0 0 6 6 6 2 AAA domain AAA_18 PF13238.6 AET39337.1 - 1.4e-14 54.7 18.7 0.16 12.5 0.0 9.2 9 0 0 9 9 6 4 AAA domain Sigma54_activ_2 PF14532.6 AET39337.1 - 3.4e-14 53.2 0.7 0.0031 17.6 0.0 6.2 5 0 0 5 5 5 2 Sigma-54 interaction domain AAA_14 PF13173.6 AET39337.1 - 6.3e-13 48.9 6.6 0.038 14.0 0.0 9.2 10 1 1 11 11 8 3 AAA domain T2SSE PF00437.20 AET39337.1 - 1.5e-12 47.2 2.9 0.077 12.0 0.0 6.4 6 0 0 6 6 6 3 Type II/IV secretion system protein RsgA_GTPase PF03193.16 AET39337.1 - 1.8e-12 47.5 6.2 0.34 10.8 0.0 6.4 6 0 0 6 6 6 4 RsgA GTPase Zeta_toxin PF06414.12 AET39337.1 - 5.3e-12 45.4 3.0 0.2 10.9 0.0 8.0 7 0 0 7 7 7 2 Zeta toxin ABC_tran PF00005.27 AET39337.1 - 5.1e-11 43.2 19.9 0.00058 20.4 0.0 7.4 8 0 0 8 8 6 3 ABC transporter RNA_helicase PF00910.22 AET39337.1 - 6.9e-11 42.5 2.5 0.77 10.2 0.0 7.7 7 0 0 7 7 6 1 RNA helicase AAA_33 PF13671.6 AET39337.1 - 2.8e-10 40.5 0.3 0.28 11.3 0.0 6.9 6 0 0 6 6 6 1 AAA domain RuvB_N PF05496.12 AET39337.1 - 7.2e-10 38.8 4.1 0.053 13.3 0.0 6.6 7 0 0 7 7 7 3 Holliday junction DNA helicase RuvB P-loop domain PduV-EutP PF10662.9 AET39337.1 - 1.1e-09 38.1 2.1 0.026 14.3 0.1 6.3 6 0 0 6 6 6 1 Ethanolamine utilisation - propanediol utilisation AAA_19 PF13245.6 AET39337.1 - 2.4e-09 37.7 3.5 0.11 12.8 0.2 5.9 6 0 0 6 6 4 1 AAA domain Mg_chelatase PF01078.21 AET39337.1 - 4.6e-09 36.0 5.4 4.2 6.7 0.1 8.5 9 1 1 10 10 9 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 AET39337.1 - 5.1e-08 33.3 3.1 4 7.7 0.0 7.3 7 0 0 7 7 6 0 AAA domain IstB_IS21 PF01695.17 AET39337.1 - 8.2e-08 32.2 0.2 1.6 8.4 0.0 6.1 6 0 0 6 6 6 1 IstB-like ATP binding protein MMR_HSR1 PF01926.23 AET39337.1 - 1.5e-07 31.4 1.9 8.4 6.5 0.0 6.7 6 0 0 6 6 6 0 50S ribosome-binding GTPase Roc PF08477.13 AET39337.1 - 1.6e-07 31.6 3.4 6.3 7.0 0.0 6.7 6 0 0 6 6 6 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 AET39337.1 - 1.7e-07 30.9 0.4 2.8 7.8 0.0 6.2 6 0 0 6 6 6 1 P-loop containing region of AAA domain DUF815 PF05673.13 AET39337.1 - 1.9e-07 30.5 1.8 0.04 13.1 0.0 5.2 5 0 0 5 5 5 1 Protein of unknown function (DUF815) AAA_25 PF13481.6 AET39337.1 - 2.1e-07 30.7 0.2 0.32 10.5 0.0 5.4 5 0 0 5 5 5 1 AAA domain Rad17 PF03215.15 AET39337.1 - 3.7e-07 30.2 8.1 0.6 10.0 0.0 7.2 7 0 0 7 7 6 1 Rad17 P-loop domain TniB PF05621.11 AET39337.1 - 4.1e-07 29.6 5.5 0.19 11.1 0.0 6.8 7 0 0 7 7 7 2 Bacterial TniB protein NACHT PF05729.12 AET39337.1 - 4.3e-07 30.0 9.1 0.39 10.6 0.0 6.2 6 0 0 6 6 4 1 NACHT domain KAP_NTPase PF07693.14 AET39337.1 - 3.5e-06 26.5 0.5 0.57 9.4 0.0 5.0 5 0 0 5 5 5 1 KAP family P-loop domain MCM PF00493.23 AET39337.1 - 5.2e-06 25.7 1.8 5.3 6.1 0.1 5.4 5 0 0 5 5 5 0 MCM P-loop domain SRPRB PF09439.10 AET39337.1 - 1.5e-05 24.5 1.9 7.6 5.9 0.0 6.2 6 0 0 6 6 6 0 Signal recognition particle receptor beta subunit VWA PF00092.28 AET39337.1 - 1.6e-05 25.2 1.3 4.8e-05 23.7 1.3 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain Viral_helicase1 PF01443.18 AET39337.1 - 5.2e-05 23.1 0.7 7.8 6.2 0.0 5.7 5 0 0 5 5 5 0 Viral (Superfamily 1) RNA helicase AAA_24 PF13479.6 AET39337.1 - 7.4e-05 22.5 3.3 2.5 7.8 0.1 6.5 7 1 0 7 7 6 1 AAA domain PhoH PF02562.16 AET39337.1 - 8.7e-05 22.1 1.0 7.8 5.9 0.0 4.8 5 0 0 5 5 5 0 PhoH-like protein Microtub_bd PF16796.5 AET39337.1 - 0.00069 19.6 3.0 2.1 8.2 0.2 4.4 4 0 0 4 4 3 1 Microtubule binding ATP-synt_ab PF00006.25 AET39337.1 - 0.00081 19.1 0.0 5 6.7 0.0 3.8 3 1 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain ATPase PF06745.13 AET39337.1 - 0.0011 18.3 0.6 4.4 6.6 0.0 4.9 5 0 0 5 5 5 0 KaiC CPT PF07931.12 AET39337.1 - 0.0012 18.8 0.4 20 5.0 0.0 5.7 5 1 0 5 5 5 0 Chloramphenicol phosphotransferase-like protein SRP54 PF00448.22 AET39337.1 - 0.0012 18.5 13.2 1.3 8.6 0.1 6.2 7 0 0 7 7 5 1 SRP54-type protein, GTPase domain dNK PF01712.19 AET39337.1 - 0.0016 18.3 5.8 20 5.0 0.0 6.5 6 0 0 6 6 6 0 Deoxynucleoside kinase PIF1 PF05970.14 AET39337.1 - 0.012 14.8 3.3 2.5 7.2 0.0 4.9 5 0 0 5 5 4 0 PIF1-like helicase ATP_bind_1 PF03029.17 AET39337.1 - 0.014 15.2 10.1 2.5 7.8 0.1 5.9 5 0 0 5 5 5 0 Conserved hypothetical ATP binding protein AAA_17 PF13207.6 AET39337.1 - 0.017 15.6 2.6 25 5.3 0.0 5.1 4 0 0 4 4 4 0 AAA domain cobW PF02492.19 AET39337.1 - 0.019 14.5 7.9 10 5.7 0.0 5.2 6 0 0 6 6 5 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 AET39337.1 - 0.028 14.4 13.6 3.4 7.5 0.2 6.3 7 0 0 7 7 5 0 NTPase FtsK_SpoIIIE PF01580.18 AET39337.1 - 0.33 10.3 1.6 25 4.1 0.1 3.6 3 0 0 3 3 3 0 FtsK/SpoIIIE family MobB PF03205.14 AET39337.1 - 1.3 8.9 9.7 75 3.2 0.1 5.2 6 0 0 6 6 4 0 Molybdopterin guanine dinucleotide synthesis protein B tRNA_int_endo PF01974.17 AET39338.1 - 1.6e-20 73.0 0.3 4e-20 71.7 0.3 1.7 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 AET39338.1 - 0.0004 20.0 0.0 0.96 9.2 0.0 2.6 2 0 0 2 2 2 2 tRNA intron endonuclease, N-terminal domain Lantibiotic_a PF14867.6 AET39339.1 - 0.11 12.3 1.3 0.33 10.7 1.3 1.9 1 0 0 1 1 1 0 Lantibiotic alpha CDC45 PF02724.14 AET39340.1 - 1.9e-199 664.1 1.3 2.3e-198 660.5 1.3 1.9 1 1 0 1 1 1 1 CDC45-like protein ANAPC9 PF12856.7 AET39341.1 - 2.7e-08 34.0 0.0 5.3e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 9 CH PF00307.31 AET39342.1 - 3.2e-81 268.6 0.8 1.5e-21 76.6 0.0 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 AET39342.1 - 5.6e-05 23.5 0.1 0.00037 20.9 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain pair CAMSAP_CH PF11971.8 AET39342.1 - 0.0028 17.5 0.0 2.1 8.2 0.0 3.9 4 0 0 4 4 4 1 CAMSAP CH domain CH_2 PF06294.11 AET39342.1 - 0.018 15.1 0.3 5.8 7.1 0.0 3.7 5 0 0 5 5 5 0 CH-like domain in sperm protein EF-hand_1 PF00036.32 AET39342.1 - 0.086 12.4 2.0 16 5.3 0.0 3.7 2 1 0 3 3 3 0 EF hand adh_short PF00106.25 AET39343.1 - 1.7e-07 30.9 0.0 7.1e-07 28.9 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase Zn_ribbon_17 PF17120.5 AET39344.1 - 5.3e-20 70.8 12.4 5.3e-20 70.8 12.4 2.0 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 AET39344.1 - 1.1e-07 32.4 17.0 0.012 16.4 0.0 5.7 5 0 0 5 5 5 3 WD domain, G-beta repeat RWD PF05773.22 AET39344.1 - 3.5e-05 24.1 0.0 0.0001 22.6 0.0 1.8 1 0 0 1 1 1 1 RWD domain C1_2 PF03107.16 AET39344.1 - 0.0035 17.6 2.4 0.0085 16.4 2.4 1.6 1 0 0 1 1 1 1 C1 domain OrfB_Zn_ribbon PF07282.11 AET39344.1 - 0.0039 17.1 1.6 0.0097 15.8 1.6 1.6 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf-RING_2 PF13639.6 AET39344.1 - 0.0077 16.6 7.5 0.024 15.0 7.5 1.9 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 AET39344.1 - 0.0084 16.4 6.9 0.0084 16.4 6.9 1.8 2 0 0 2 2 1 1 RING-H2 zinc finger domain C1_1 PF00130.22 AET39344.1 - 0.19 11.6 6.9 0.43 10.5 6.9 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-ANAPC11 PF12861.7 AET39344.1 - 0.26 11.4 6.5 0.77 9.9 6.5 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 AET39344.1 - 0.33 10.8 8.6 0.54 10.2 6.9 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_16 PF17034.5 AET39344.1 - 0.42 10.8 8.3 0.74 10.0 7.4 1.9 2 0 0 2 2 2 0 Zinc-ribbon like family DHHC PF01529.20 AET39345.1 - 3.4e-26 91.9 13.6 3.4e-26 91.9 13.6 2.8 2 2 1 3 3 3 1 DHHC palmitoyltransferase HEPN_Cthe2314 PF18730.1 AET39345.1 - 0.039 14.0 1.5 0.062 13.3 1.5 1.3 1 0 0 1 1 1 0 Cthe_2314-like HEPN Abhydrolase_1 PF00561.20 AET39348.1 - 4.6e-13 49.4 0.0 4.7e-11 42.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AET39348.1 - 1.6e-12 47.2 0.0 8.2e-08 31.8 0.0 2.5 2 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 AET39348.1 - 7.5e-11 43.0 0.0 1.2e-10 42.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.11 AET39348.1 - 0.00036 19.9 0.0 0.058 12.7 0.0 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) LIDHydrolase PF10230.9 AET39348.1 - 0.0019 17.8 0.0 0.034 13.7 0.0 2.1 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase Thioesterase PF00975.20 AET39348.1 - 0.0046 17.1 0.0 0.01 15.9 0.0 1.6 1 0 0 1 1 1 1 Thioesterase domain Esterase PF00756.20 AET39348.1 - 0.006 16.3 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Ndr PF03096.14 AET39348.1 - 0.0073 15.0 0.0 0.042 12.5 0.0 1.9 2 0 0 2 2 2 1 Ndr family PGAP1 PF07819.13 AET39348.1 - 0.18 11.5 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Fungal_trans PF04082.18 AET39349.1 - 8.2e-37 126.7 1.7 1.8e-36 125.5 1.7 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET39349.1 - 3.1e-09 36.8 9.3 5.8e-09 35.9 9.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2841 PF11001.8 AET39350.1 - 9.4e-37 125.8 2.2 2e-36 124.8 2.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) TPR_11 PF13414.6 AET39351.1 - 0.00036 20.1 0.0 0.00066 19.3 0.0 1.4 1 0 0 1 1 1 1 TPR repeat F-box-like PF12937.7 AET39351.1 - 0.00048 20.0 0.2 0.0015 18.4 0.2 1.8 1 0 0 1 1 1 1 F-box-like TPR_1 PF00515.28 AET39351.1 - 0.001 18.8 0.0 0.0025 17.6 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 AET39351.1 - 0.0019 18.2 0.0 0.0046 17.0 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 AET39351.1 - 0.13 12.5 0.0 0.49 10.7 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat SUIM_assoc PF16619.5 AET39353.1 - 0.0029 17.6 0.1 0.16 12.1 0.0 2.4 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 Pkinase PF00069.25 AET39354.1 - 3.4e-68 229.9 0.8 1.5e-62 211.4 0.2 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AET39354.1 - 5.4e-39 134.0 0.3 2e-37 128.9 0.3 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 AET39354.1 - 8.1e-18 64.0 0.0 1.6e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 AET39354.1 - 7.4e-07 28.8 0.0 1.2e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 AET39354.1 - 0.00013 21.4 0.1 0.00027 20.4 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AET39354.1 - 0.0015 18.5 0.0 0.014 15.3 0.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 AET39354.1 - 0.0016 17.5 1.1 0.0051 15.8 0.1 2.3 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 AET39354.1 - 0.0035 16.2 0.0 0.0035 16.2 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 AET39354.1 - 0.077 12.6 0.3 0.24 11.0 0.3 1.8 1 0 0 1 1 1 0 RIO1 family PHD PF00628.29 AET39355.1 - 0.028 14.3 3.5 0.081 12.8 3.5 1.8 1 0 0 1 1 1 0 PHD-finger DUF3915 PF13054.6 AET39355.1 - 0.068 13.2 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) MTP18 PF10558.9 AET39355.1 - 0.32 11.0 3.1 0.89 9.5 0.2 2.4 2 0 0 2 2 2 0 Mitochondrial 18 KDa protein (MTP18) SurE PF01975.17 AET39356.1 - 0.028 14.2 2.9 0.5 10.1 1.6 2.3 2 0 0 2 2 2 0 Survival protein SurE Nyv1_N PF09426.10 AET39357.1 - 3.7e-55 185.7 0.8 5.7e-55 185.1 0.8 1.3 1 0 0 1 1 1 1 Vacuolar R-SNARE Nyv1 N terminal Synaptobrevin PF00957.21 AET39357.1 - 4.6e-27 93.6 3.5 7.5e-27 93.0 3.5 1.3 1 0 0 1 1 1 1 Synaptobrevin IKBKB_SDD PF18397.1 AET39357.1 - 0.00092 18.6 0.3 0.00096 18.5 0.3 1.1 1 0 0 1 1 1 1 IQBAL scaffold dimerization domain Helicase_IV_N PF12462.8 AET39357.1 - 0.0094 15.9 0.9 0.015 15.3 0.9 1.3 1 0 0 1 1 1 1 DNA helicase IV / RNA helicase N terminal MCU PF04678.13 AET39357.1 - 0.057 13.5 0.6 0.062 13.4 0.6 1.4 1 1 0 1 1 1 0 Mitochondrial calcium uniporter DUF2158 PF09926.9 AET39357.1 - 0.069 12.9 0.4 0.16 11.7 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized small protein (DUF2158) Coronavirus_5 PF05528.11 AET39357.1 - 0.12 12.4 0.0 0.33 11.0 0.0 1.7 1 0 0 1 1 1 0 Coronavirus gene 5 protein CBFD_NFYB_HMF PF00808.23 AET39358.1 - 2.9e-06 27.5 0.4 5.5e-06 26.6 0.4 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 AET39358.1 - 0.0012 19.0 0.2 0.0016 18.5 0.2 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 AET39358.1 - 0.041 14.2 0.2 0.041 14.2 0.2 1.8 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 TRM PF02005.16 AET39359.1 - 2.4e-137 458.1 0.0 2.9e-137 457.8 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 AET39359.1 - 4.8e-05 23.2 0.0 0.0001 22.2 0.0 1.5 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 AET39359.1 - 0.18 11.4 0.0 0.34 10.5 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 MFS_1 PF07690.16 AET39361.1 - 7.8e-41 140.2 44.6 5.7e-40 137.3 44.6 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AET39361.1 - 1.3e-13 50.7 20.0 1.3e-13 50.7 20.0 3.7 3 1 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 AET39361.1 - 8.2e-06 24.5 6.9 8.2e-06 24.5 6.9 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 AET39361.1 - 0.084 11.2 4.6 0.15 10.4 4.6 1.4 1 0 0 1 1 1 0 Transmembrane secretion effector Sulfate_transp PF00916.20 AET39362.1 - 5.1e-113 377.7 18.9 7e-113 377.2 18.9 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 AET39362.1 - 0.0072 16.0 0.0 0.019 14.6 0.0 1.7 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 AET39362.1 - 0.0095 16.3 1.1 0.0095 16.3 1.1 3.2 2 1 1 3 3 3 1 Molybdate transporter of MFS superfamily ANAPC4 PF12896.7 AET39363.1 - 1e-29 103.5 3.1 2.1e-29 102.5 3.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 HTH_25 PF13413.6 AET39363.1 - 0.19 11.6 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain SUI1 PF01253.22 AET39364.1 - 8.7e-18 64.6 0.6 3.1e-17 62.8 0.0 2.2 2 0 0 2 2 2 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 AET39364.1 - 2.6e-10 40.8 0.9 2.6e-10 40.8 0.9 2.6 3 0 0 3 3 3 1 Pre-PUA-like domain SWIB PF02201.18 AET39364.1 - 0.0009 19.1 0.1 0.0053 16.6 0.0 2.2 2 0 0 2 2 2 1 SWIB/MDM2 domain Kin17_mid PF10357.9 AET39364.1 - 0.021 14.7 0.3 0.055 13.4 0.3 1.7 1 0 0 1 1 1 0 Domain of Kin17 curved DNA-binding protein Uricase PF01014.18 AET39364.1 - 0.059 13.6 0.1 0.17 12.1 0.0 1.8 1 1 0 1 1 1 0 Uricase Ribosomal_L1 PF00687.21 AET39365.1 - 2.6e-27 95.9 0.3 3.1e-27 95.6 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Phytochelatin PF05023.14 AET39365.1 - 0.066 12.4 0.0 3.8 6.7 0.0 2.3 2 0 0 2 2 2 0 Phytochelatin synthase Ribosomal_L34 PF00468.17 AET39366.1 - 3.2e-18 65.4 7.8 3.2e-18 65.4 7.8 1.8 1 1 1 2 2 2 1 Ribosomal protein L34 DUF2418 PF10332.9 AET39366.1 - 0.029 14.9 0.1 0.037 14.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2418) GEP5 PF17053.5 AET39367.1 - 1.7e-83 279.9 0.3 2e-83 279.6 0.3 1.1 1 0 0 1 1 1 1 Genetic interactor of prohibitin 5 Securin PF04856.13 AET39368.1 - 8.5e-30 104.4 5.9 1.2e-29 104.0 5.9 1.1 1 0 0 1 1 1 1 Securin sister-chromatid separation inhibitor Trypan_PARP PF05887.11 AET39368.1 - 0.14 12.2 2.0 0.13 12.2 0.7 1.6 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DnaJ_C PF01556.18 AET39369.1 - 3e-32 111.7 0.0 4.1e-32 111.3 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AET39369.1 - 7.6e-25 86.8 1.8 1.5e-24 85.9 1.8 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 AET39369.1 - 5.6e-10 39.4 14.8 1.1e-09 38.5 14.8 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 AET39369.1 - 0.00072 19.5 12.6 0.012 15.5 1.9 2.5 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein Cytochrom_c3_2 PF14537.6 AET39369.1 - 1.4 9.4 5.6 0.65 10.5 0.7 2.4 2 0 0 2 2 2 0 Cytochrome c3 zinc_ribbon_6 PF14599.6 AET39369.1 - 3.5 7.7 6.7 6.3 6.9 0.9 2.5 2 0 0 2 2 2 0 Zinc-ribbon Aminotran_1_2 PF00155.21 AET39370.1 - 2.3e-38 132.3 0.0 3.5e-38 131.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 AET39370.1 - 0.056 12.7 0.0 0.1 11.8 0.0 1.4 2 0 0 2 2 2 0 Beta-eliminating lyase Get5_C PF18514.1 AET39371.1 - 0.17 11.7 0.0 0.44 10.3 0.0 1.7 1 0 0 1 1 1 0 Get5 C-terminal domain Gaa1 PF04114.14 AET39372.1 - 1.3e-120 403.8 18.8 2.5e-120 402.8 18.8 1.5 1 1 0 1 1 1 1 Gaa1-like, GPI transamidase component SMC_N PF02463.19 AET39374.1 - 1.5e-71 240.3 42.5 2.2e-40 138.5 1.2 3.4 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 AET39374.1 - 8.1e-26 90.6 0.0 2.9e-25 88.9 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 AET39374.1 - 8.1e-12 45.6 8.5 2.4e-05 24.3 0.0 3.6 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 AET39374.1 - 2.2e-05 24.4 31.0 2.2e-05 24.4 31.0 4.6 2 2 2 4 4 4 1 AAA ATPase domain AAA_29 PF13555.6 AET39374.1 - 0.00013 21.6 0.0 0.00031 20.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Seryl_tRNA_N PF02403.22 AET39374.1 - 0.011 16.0 12.1 0.011 16.0 12.1 8.0 3 3 5 9 9 9 0 Seryl-tRNA synthetase N-terminal domain Leucyl-specific PF14795.6 AET39374.1 - 0.41 10.8 4.9 4.8 7.3 0.1 4.3 3 0 0 3 3 3 0 Leucine-tRNA synthetase-specific domain ABC_tran PF00005.27 AET39374.1 - 0.78 10.2 0.0 0.78 10.2 0.0 6.3 3 2 0 3 3 3 0 ABC transporter Actin PF00022.19 AET39375.1 - 3.9e-53 180.5 0.0 5.3e-52 176.8 0.0 1.9 1 1 0 1 1 1 1 Actin FGGY_C PF02782.16 AET39376.1 - 2.1e-45 154.9 0.0 3.2e-45 154.3 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 AET39376.1 - 2.2e-23 83.1 0.0 1.2e-22 80.7 0.0 2.2 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Hexokinase_1 PF00349.21 AET39376.1 - 0.0032 17.4 0.0 0.0069 16.3 0.0 1.5 1 0 0 1 1 1 1 Hexokinase GCR1_C PF12550.8 AET39377.1 - 1.1e-09 38.5 0.1 2.3e-09 37.4 0.1 1.6 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Rax2 PF12768.7 AET39378.1 - 8.4e-53 179.0 0.4 8.4e-53 179.0 0.4 3.8 5 0 0 5 5 5 1 Cortical protein marker for cell polarity TRAPPC-Trs85 PF12739.7 AET39379.1 - 2e-95 320.2 0.1 4.7e-95 318.9 0.1 1.6 1 1 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit EMP70 PF02990.16 AET39380.1 - 5.8e-168 559.8 21.2 7.9e-168 559.3 21.2 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 Tmpp129 PF10272.9 AET39380.1 - 0.19 11.0 2.0 0.15 11.3 0.5 1.5 1 1 0 1 1 1 0 Putative transmembrane protein precursor Ribonuc_red_lgC PF02867.15 AET39381.1 - 1.2e-185 618.0 0.0 1.6e-185 617.6 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 AET39381.1 - 2.7e-24 85.0 0.4 8e-24 83.5 0.0 2.0 2 0 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 AET39381.1 - 1.2e-16 61.0 0.5 4.3e-16 59.3 0.1 2.2 2 0 0 2 2 2 1 ATP cone domain Fis1_TPR_C PF14853.6 AET39382.1 - 2.6e-21 75.4 1.1 4.8e-21 74.6 1.1 1.4 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 AET39382.1 - 2.8e-17 62.1 0.1 1.2e-16 60.1 0.0 1.9 2 0 0 2 2 2 1 Fis1 N-terminal tetratricopeptide repeat TPR_19 PF14559.6 AET39382.1 - 0.044 14.3 0.2 0.43 11.1 0.2 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat Methyltransf_31 PF13847.6 AET39383.1 - 3.3e-23 82.2 0.0 5.1e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AET39383.1 - 9.2e-11 42.3 0.1 1.8e-10 41.4 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AET39383.1 - 9.9e-11 42.3 0.0 1.5e-10 41.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AET39383.1 - 1e-10 42.1 0.1 1.9e-10 41.2 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 AET39383.1 - 1.7e-06 28.1 0.0 4e-06 26.9 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AET39383.1 - 1.8e-05 24.7 0.0 2.4e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 AET39383.1 - 2.8e-05 24.0 0.0 3.8e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.13 AET39383.1 - 0.00023 20.8 0.2 0.00042 19.9 0.2 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 CMAS PF02353.20 AET39383.1 - 0.0003 20.2 0.4 0.00042 19.7 0.4 1.3 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 AET39383.1 - 0.00031 20.7 0.0 0.00046 20.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AET39383.1 - 0.00097 18.7 0.0 0.0014 18.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Spermine_synth PF01564.17 AET39383.1 - 0.014 14.8 0.1 0.071 12.5 0.0 1.8 1 1 1 2 2 2 0 Spermine/spermidine synthase domain Methyltransf_9 PF08003.11 AET39383.1 - 0.055 12.4 0.0 0.074 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) MetW PF07021.12 AET39383.1 - 0.057 13.0 0.1 0.097 12.3 0.1 1.6 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Ubie_methyltran PF01209.18 AET39383.1 - 0.06 12.7 0.0 0.079 12.3 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF1797 PF08796.10 AET39383.1 - 0.068 13.3 1.8 0.51 10.5 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1797) PrmA PF06325.13 AET39383.1 - 0.082 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) GidB PF02527.15 AET39383.1 - 0.14 11.4 0.0 2 7.7 0.0 2.1 2 0 0 2 2 2 0 rRNA small subunit methyltransferase G RrnaAD PF00398.20 AET39383.1 - 0.2 10.7 0.0 0.33 10.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Ran_BP1 PF00638.18 AET39384.1 - 6.9e-30 103.8 0.0 1.5e-29 102.7 0.0 1.6 1 0 0 1 1 1 1 RanBP1 domain P16-Arc PF04699.14 AET39385.1 - 9.9e-44 149.4 0.0 1.1e-43 149.3 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Sigma70_r4 PF04545.16 AET39385.1 - 0.13 11.9 0.1 0.37 10.4 0.1 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 NAT PF04768.13 AET39386.1 - 4.7e-52 176.1 0.0 1e-51 174.9 0.0 1.6 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Semialdhyde_dh PF01118.24 AET39386.1 - 5.1e-30 104.4 0.0 9.7e-30 103.5 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.28 AET39386.1 - 5.4e-23 81.8 0.0 8.2e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 Amino acid kinase family Semialdhyde_dhC PF02774.18 AET39386.1 - 1.2e-07 32.0 0.0 3.2e-07 30.6 0.0 1.8 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain DapB_N PF01113.20 AET39386.1 - 0.0097 16.0 0.0 0.02 15.0 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus U1snRNP70_N PF12220.8 AET39387.1 - 3.9e-20 72.3 3.2 9.1e-20 71.1 3.2 1.6 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 AET39387.1 - 3e-15 55.8 0.1 5.6e-15 54.9 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AET39387.1 - 0.00015 21.8 0.0 0.00035 20.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif PHM7_cyt PF14703.6 AET39387.1 - 0.072 13.3 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter zf-RING_4 PF14570.6 AET39388.1 - 3e-20 71.7 13.1 5.7e-20 70.8 13.1 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 AET39388.1 - 1.6e-08 34.2 0.0 3.8e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 AET39388.1 - 4.2e-07 29.7 8.1 4.2e-07 29.7 8.1 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Baculo_IE-1 PF05290.11 AET39388.1 - 3.1e-06 27.2 3.7 6.6e-06 26.1 3.7 1.5 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) SET_assoc PF11767.8 AET39388.1 - 0.00043 19.9 0.2 0.01 15.5 0.0 2.6 2 0 0 2 2 2 1 Histone lysine methyltransferase SET associated zf-RING_2 PF13639.6 AET39388.1 - 0.00059 20.1 9.5 0.00059 20.1 9.5 1.8 2 0 0 2 2 1 1 Ring finger domain Prok-RING_4 PF14447.6 AET39388.1 - 0.00068 19.4 7.2 0.024 14.5 7.8 2.5 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 Rtf2 PF04641.12 AET39388.1 - 0.00086 18.7 3.2 0.00086 18.7 3.2 2.2 2 0 0 2 2 2 1 Rtf2 RING-finger zf-C3HC4 PF00097.25 AET39388.1 - 0.0049 16.7 10.8 0.011 15.6 10.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3H1 PF10650.9 AET39388.1 - 0.17 11.7 2.5 0.19 11.5 0.1 2.3 2 0 0 2 2 2 0 Putative zinc-finger domain zf-RING_UBOX PF13445.6 AET39388.1 - 0.46 10.5 9.0 1.5 8.9 9.0 2.0 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 AET39388.1 - 0.57 10.1 9.9 1.3 8.9 9.9 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AET39388.1 - 0.59 10.1 9.8 1.4 9.0 9.8 1.7 1 0 0 1 1 1 0 zinc-RING finger domain Peptidase_S49_N PF08496.10 AET39388.1 - 0.65 10.0 9.9 0.33 11.0 0.5 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal PocR PF10114.9 AET39388.1 - 0.88 9.3 6.1 0.25 11.1 2.2 2.0 2 0 0 2 2 2 0 Sensory domain found in PocR zf-C3HC4_4 PF15227.6 AET39388.1 - 4.8 7.4 10.2 25 5.1 10.2 2.3 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING RGI1 PF10843.8 AET39389.1 - 9.2e-35 120.1 10.1 2e-34 119.0 10.1 1.5 1 1 0 1 1 1 1 Respiratory growth induced protein 1 DUF5100 PF17029.5 AET39389.1 - 0.092 12.6 2.0 0.16 11.8 2.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5100) ICL PF00463.21 AET39390.1 - 2.2e-276 917.4 0.2 2.6e-276 917.2 0.2 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 AET39390.1 - 2.5e-10 40.2 0.7 1.1e-09 38.2 0.0 2.2 2 1 1 3 3 3 1 Phosphoenolpyruvate phosphomutase Vhr1 PF04001.13 AET39391.1 - 5.2e-46 154.9 1.7 1.5e-45 153.4 1.7 1.8 1 0 0 1 1 1 1 Transcription factor Vhr1 DUF2407 PF10302.9 AET39391.1 - 0.19 12.3 1.5 1.9 9.1 0.0 3.0 3 0 0 3 3 3 0 DUF2407 ubiquitin-like domain Tho1_MOS11_C PF18592.1 AET39393.1 - 1.6e-24 85.4 0.6 3.1e-24 84.5 0.6 1.5 1 0 0 1 1 1 1 Tho1/MOS11 C-terminal domain SAP PF02037.27 AET39393.1 - 1.6e-14 53.2 0.3 4.6e-14 51.8 0.1 1.9 2 0 0 2 2 2 1 SAP domain PASTA PF03793.19 AET39393.1 - 0.06 13.2 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 PASTA domain DUF5634_N PF18672.1 AET39393.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5634) DUF4333 PF14230.6 AET39393.1 - 0.34 11.2 2.0 0.75 10.1 1.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4333) DUF4719 PF15843.5 AET39393.1 - 1.3 9.1 5.9 1.9 8.6 5.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) HAD_2 PF13419.6 AET39394.1 - 2.4e-14 53.8 0.0 3.2e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AET39394.1 - 9.8e-10 39.1 0.0 1.4e-06 28.8 0.0 2.2 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AET39394.1 - 0.00052 20.0 0.0 0.001 19.1 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like ADH_zinc_N PF00107.26 AET39394.1 - 0.0018 18.2 0.1 0.004 17.1 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase HAD PF12710.7 AET39394.1 - 0.073 13.5 0.0 0.086 13.2 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase ketoacyl-synt PF00109.26 AET39395.1 - 1.8e-49 168.6 0.0 2.5e-49 168.2 0.0 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 AET39395.1 - 2.3e-30 105.1 0.1 3.9e-30 104.3 0.1 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 AET39395.1 - 0.021 14.2 0.0 0.045 13.1 0.0 1.5 1 0 0 1 1 1 0 Thiolase, N-terminal domain Steroid_dh PF02544.16 AET39396.1 - 1e-13 51.6 1.7 1e-13 51.6 1.7 2.0 1 1 1 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase Transp_cyt_pur PF02133.15 AET39397.1 - 7.3e-79 265.6 40.9 8.8e-79 265.3 40.9 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Cyclin PF08613.11 AET39398.1 - 2.6e-46 157.9 1.5 4.3e-46 157.2 1.2 1.4 1 1 0 1 1 1 1 Cyclin PET117 PF15786.5 AET39399.1 - 1.8e-30 105.0 4.1 3.3e-30 104.1 4.1 1.4 1 1 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial DUF3035 PF11233.8 AET39399.1 - 0.0094 16.2 1.7 0.01 16.1 1.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3035) Sugar_tr PF00083.24 AET39399.1 - 0.015 14.2 0.0 0.016 14.1 0.0 1.0 1 0 0 1 1 1 0 Sugar (and other) transporter HJURP_mid PF12346.8 AET39399.1 - 0.03 14.8 0.2 0.04 14.4 0.2 1.3 1 0 0 1 1 1 0 Holliday junction recognition protein-associated repeat Asp-B-Hydro_N PF05279.11 AET39399.1 - 0.11 12.6 5.1 0.12 12.4 5.1 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CLN3 PF02487.17 AET39399.1 - 0.36 9.8 0.4 0.44 9.6 0.4 1.0 1 0 0 1 1 1 0 CLN3 protein Ribosomal_L34e PF01199.18 AET39400.1 - 1.9e-42 143.5 4.0 1.9e-42 143.5 4.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L34e PhoLip_ATPase_C PF16212.5 AET39401.1 - 3.7e-52 177.5 14.5 3.7e-52 177.5 14.5 2.3 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 AET39401.1 - 2.2e-18 65.7 2.8 6e-18 64.3 2.8 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 AET39401.1 - 5.5e-13 48.8 0.0 1.8e-12 47.1 0.0 1.9 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 AET39401.1 - 5.7e-10 39.8 0.4 2.9e-05 24.5 0.1 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AET39401.1 - 5.9e-10 39.1 0.0 1.5e-08 34.6 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Prot_ATP_ID_OB PF16450.5 AET39401.1 - 7e-05 22.7 0.0 0.00019 21.3 0.0 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain Hydrolase_3 PF08282.12 AET39401.1 - 0.0093 15.7 0.0 0.035 13.8 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Internalin_N PF12354.8 AET39401.1 - 0.1 12.7 0.5 2.4 8.3 0.0 3.0 2 0 0 2 2 2 0 Bacterial adhesion/invasion protein N terminal EXS PF03124.14 AET39402.1 - 2.6e-84 283.4 33.5 3.7e-84 282.9 33.5 1.2 1 0 0 1 1 1 1 EXS family SPX PF03105.19 AET39402.1 - 9e-37 127.9 12.5 8e-24 85.3 0.3 2.8 2 1 1 3 3 3 2 SPX domain HSF_DNA-bind PF00447.17 AET39402.1 - 0.013 16.1 1.6 0.12 13.0 1.0 2.4 2 0 0 2 2 2 0 HSF-type DNA-binding HisG PF01634.18 AET39403.1 - 7.7e-54 182.0 0.2 1.1e-53 181.4 0.2 1.3 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 AET39403.1 - 1.3e-25 89.3 0.0 2.5e-25 88.4 0.0 1.5 1 0 0 1 1 1 1 HisG, C-terminal domain NMT1 PF09084.11 AET39403.1 - 0.0025 17.8 0.1 0.0045 17.0 0.1 1.4 1 1 0 1 1 1 1 NMT1/THI5 like WD40 PF00400.32 AET39404.1 - 6.7e-38 128.0 29.9 1.2e-06 29.1 1.0 8.2 7 1 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 AET39404.1 - 6.8e-15 54.7 0.4 1.9e-14 53.3 0.4 1.8 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 AET39404.1 - 3.4e-10 39.2 14.7 0.0055 15.4 0.2 5.5 4 2 2 6 6 6 4 Nucleoporin Nup120/160 F-box PF00646.33 AET39404.1 - 1.3e-09 37.7 0.4 3.7e-09 36.2 0.4 1.9 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 AET39404.1 - 2.4e-07 30.9 0.8 2.6 8.4 0.0 5.3 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AET39404.1 - 0.00031 20.2 0.7 0.082 12.2 0.3 3.2 2 2 0 2 2 2 1 WD40-like domain BBS2_Mid PF14783.6 AET39404.1 - 0.00041 20.4 0.0 0.86 9.7 0.0 4.2 3 1 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region F-box_4 PF15966.5 AET39404.1 - 0.0084 16.0 0.3 0.032 14.1 0.0 2.2 2 0 0 2 2 2 1 F-box eIF2A PF08662.11 AET39404.1 - 0.04 13.8 0.3 15 5.4 0.0 3.1 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A CBM_21 PF03370.13 AET39405.1 - 4.9e-27 94.3 0.2 1.2e-26 93.1 0.2 1.7 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 AET39405.1 - 4.6e-12 46.4 0.4 9.6e-12 45.3 0.4 1.6 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) ArfGap PF01412.18 AET39406.1 - 1.2e-36 125.3 0.1 2e-36 124.6 0.1 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Cyt-b5 PF00173.28 AET39407.1 - 2.6e-19 69.1 0.0 4.3e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain AA_kinase PF00696.28 AET39408.1 - 2.4e-40 138.7 0.0 5.3e-40 137.5 0.0 1.6 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.25 AET39408.1 - 1.7e-12 46.9 0.4 6.3e-05 22.7 0.0 2.7 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.6 AET39408.1 - 2e-08 33.9 2.3 7.8e-06 25.6 0.4 2.6 2 0 0 2 2 2 2 ACT domain DUF1368 PF07112.11 AET39408.1 - 0.019 13.8 1.4 0.029 13.2 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1368) NAD_binding_1 PF00175.21 AET39409.1 - 2.3e-29 102.3 0.0 3.4e-29 101.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 AET39409.1 - 3.4e-28 97.9 0.0 5.8e-28 97.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 AET39409.1 - 0.00011 22.3 0.0 0.0044 17.1 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Iron_permease PF04120.12 AET39409.1 - 0.17 11.7 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 Low affinity iron permease Cupin_8 PF13621.6 AET39410.1 - 1.9e-07 31.1 0.1 1.8e-06 27.9 0.1 2.1 1 1 0 1 1 1 1 Cupin-like domain PHD PF00628.29 AET39410.1 - 2.6e-06 27.2 5.2 2.6e-06 27.2 5.2 1.9 2 0 0 2 2 2 1 PHD-finger C1_1 PF00130.22 AET39410.1 - 0.0021 17.9 2.1 0.0057 16.5 2.1 1.8 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_Oberon PF07227.11 AET39410.1 - 0.0094 15.8 1.1 0.021 14.7 1.1 1.5 1 0 0 1 1 1 1 PHD - plant homeodomain finger protein DUF810 PF05664.11 AET39410.1 - 0.01 14.5 0.0 0.015 13.9 0.0 1.2 1 0 0 1 1 1 1 Plant family of unknown function (DUF810) JmjC PF02373.22 AET39410.1 - 0.015 15.7 0.0 0.23 11.9 0.0 2.7 2 1 0 2 2 2 0 JmjC domain, hydroxylase Cupin_4 PF08007.12 AET39410.1 - 0.015 14.7 0.0 0.04 13.4 0.0 1.6 1 0 0 1 1 1 0 Cupin superfamily protein JHD PF17811.1 AET39410.1 - 0.032 14.8 0.1 0.084 13.4 0.0 1.8 2 0 0 2 2 2 0 Jumonji helical domain zf-HC5HC2H_2 PF13832.6 AET39410.1 - 0.062 13.5 2.4 0.15 12.3 2.4 1.7 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 AET39410.1 - 0.15 12.4 4.7 0.094 13.0 2.5 1.9 2 0 0 2 2 2 0 PHD-like zinc-binding domain Cupin_1 PF00190.22 AET39410.1 - 0.15 11.7 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Cupin Peptidase_C48 PF02902.19 AET39411.1 - 4.7e-34 118.1 5.3 9.6e-34 117.1 5.3 1.6 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain RINGv PF12906.7 AET39412.1 - 7.5e-15 54.8 6.7 1.3e-14 54.0 6.7 1.4 1 0 0 1 1 1 1 RING-variant domain FANCL_C PF11793.8 AET39412.1 - 3.9 7.7 6.2 13 6.0 6.2 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain SDA1 PF05285.12 AET39412.1 - 7.8 5.8 15.4 11 5.3 15.4 1.1 1 0 0 1 1 1 0 SDA1 ANAPC_CDC26 PF10471.9 AET39413.1 - 1.8e-19 70.4 7.0 3.2e-19 69.5 7.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex APC subunit CDC26 DUF1454 PF07305.12 AET39413.1 - 0.012 15.0 0.1 0.014 14.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1454) MMgT PF10270.9 AET39414.1 - 1.6e-27 95.8 1.4 1.8e-26 92.4 1.4 2.0 1 1 0 1 1 1 1 Membrane magnesium transporter STAG PF08514.11 AET39415.1 - 5.4e-29 100.4 3.3 5.4e-29 100.4 3.3 2.9 2 0 0 2 2 2 1 STAG domain HEAT PF02985.22 AET39415.1 - 0.13 12.6 0.5 2.1 8.8 0.0 3.3 3 0 0 3 3 3 0 HEAT repeat AMPK1_CBM PF16561.5 AET39416.1 - 0.00082 19.5 0.7 0.0021 18.2 0.7 1.6 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 AET39416.1 - 0.013 15.8 0.1 0.025 14.9 0.1 1.4 1 0 0 1 1 1 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) SR-25 PF10500.9 AET39416.1 - 0.013 15.1 11.8 0.022 14.4 11.8 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Nop14 PF04147.12 AET39416.1 - 0.92 7.6 11.3 1.1 7.4 11.3 1.0 1 0 0 1 1 1 0 Nop14-like family Menin PF05053.13 AET39416.1 - 1.8 6.8 6.0 2.3 6.5 6.0 1.1 1 0 0 1 1 1 0 Menin Macoilin PF09726.9 AET39416.1 - 4.5 5.7 10.3 5.2 5.5 10.3 1.1 1 0 0 1 1 1 0 Macoilin family MFS_1 PF07690.16 AET39417.1 - 1.6e-30 106.3 57.0 7.7e-27 94.1 31.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 AET39417.1 - 6.6e-07 28.5 34.6 0.00036 19.5 14.4 2.4 1 1 1 2 2 2 2 Sugar (and other) transporter Zip PF02535.22 AET39418.1 - 1.7e-49 168.9 1.5 7.4e-40 137.2 0.3 2.0 1 1 1 2 2 2 2 ZIP Zinc transporter SWIRM PF04433.17 AET39419.1 - 2.5e-28 98.3 0.3 7e-28 96.8 0.3 1.8 1 0 0 1 1 1 1 SWIRM domain ZZ PF00569.17 AET39419.1 - 1.6e-09 37.4 2.3 2.5e-09 36.8 2.3 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.31 AET39419.1 - 2.2e-09 37.3 0.0 1.8e-08 34.4 0.1 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain SWIRM-assoc_1 PF16495.5 AET39419.1 - 3.5e-08 33.3 3.6 3.5e-08 33.3 3.6 2.4 3 0 0 3 3 3 1 SWIRM-associated region 1 Myb_DNA-bind_6 PF13921.6 AET39419.1 - 1.3e-07 31.7 0.1 8.5e-06 25.9 0.0 3.1 3 0 0 3 3 3 1 Myb-like DNA-binding domain zf-UBR PF02207.20 AET39419.1 - 0.0076 16.4 1.3 0.014 15.5 1.3 1.4 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Elf1 PF05129.13 AET39419.1 - 0.048 13.7 0.2 0.11 12.5 0.2 1.5 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zf-CCHC_2 PF13696.6 AET39419.1 - 0.58 10.0 3.0 0.68 9.8 0.2 2.1 2 0 0 2 2 2 0 Zinc knuckle Erg28 PF03694.13 AET39420.1 - 7.3e-43 145.4 2.7 9.8e-43 145.0 2.7 1.2 1 0 0 1 1 1 1 Erg28 like protein DUF308 PF03729.13 AET39420.1 - 0.02 15.2 2.3 0.024 15.0 0.4 2.1 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) CoA_binding_3 PF13727.6 AET39420.1 - 0.22 11.5 1.9 0.31 11.0 1.9 1.4 1 0 0 1 1 1 0 CoA-binding domain F_actin_cap_B PF01115.17 AET39421.1 - 6.7e-87 291.1 0.1 7.7e-87 290.9 0.1 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit Pkinase PF00069.25 AET39422.1 - 5.5e-61 206.2 8.4 4.6e-54 183.6 0.9 2.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AET39422.1 - 2.6e-20 72.8 3.1 9.4e-16 57.9 0.1 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.23 AET39422.1 - 2.2e-06 27.8 0.0 1.3e-05 25.2 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 AET39422.1 - 0.0086 14.9 0.8 0.017 13.9 0.0 1.8 3 0 0 3 3 3 1 Fungal protein kinase Kdo PF06293.14 AET39422.1 - 0.013 14.9 0.3 0.024 14.0 0.3 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 AET39422.1 - 0.027 14.1 0.7 0.07 12.7 0.1 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase DUF496 PF04363.12 AET39422.1 - 0.14 12.2 3.2 0.55 10.3 0.7 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF496) bZIP_1 PF00170.21 AET39424.1 - 1e-15 57.5 11.5 1e-15 57.5 11.5 2.1 3 0 0 3 3 3 1 bZIP transcription factor bZIP_2 PF07716.15 AET39424.1 - 7.3e-08 32.4 8.9 7.3e-08 32.4 8.9 1.6 2 0 0 2 2 2 1 Basic region leucine zipper TFIIA PF03153.13 AET39424.1 - 0.01 15.9 13.5 0.012 15.7 13.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit bZIP_Maf PF03131.17 AET39424.1 - 0.032 14.7 6.1 0.032 14.7 6.1 2.3 2 0 0 2 2 2 0 bZIP Maf transcription factor SMYLE_N PF18615.1 AET39425.1 - 4.8 6.6 8.7 7.6 6.0 8.7 1.4 1 1 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Toxin_trans PF07952.12 AET39426.1 - 0.0046 16.1 0.3 0.0083 15.3 0.3 1.4 1 0 0 1 1 1 1 Clostridium neurotoxin, Translocation domain KTI12 PF08433.10 AET39426.1 - 0.088 12.2 2.6 0.078 12.4 0.7 1.9 2 0 0 2 2 2 0 Chromatin associated protein KTI12 NPCC PF08058.11 AET39426.1 - 0.3 11.2 2.4 0.42 10.7 0.7 2.2 2 1 0 2 2 2 0 Nuclear pore complex component DnaJ-X PF14308.6 AET39428.1 - 3.5e-52 176.9 4.1 8.4e-52 175.7 4.1 1.6 1 0 0 1 1 1 1 X-domain of DnaJ-containing DnaJ PF00226.31 AET39428.1 - 3e-26 91.3 5.0 5.6e-26 90.5 2.0 2.7 2 0 0 2 2 2 1 DnaJ domain DUF3939 PF13075.6 AET39428.1 - 0.024 14.7 0.1 0.044 13.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3939) Apq12 PF12716.7 AET39429.1 - 0.025 14.5 12.1 0.046 13.7 12.1 1.5 1 0 0 1 1 1 0 Nuclear pore assembly and biogenesis TNFR_16_TM PF18422.1 AET39429.1 - 5.2 7.1 8.6 26 4.9 1.4 3.3 3 0 0 3 3 3 0 Tumor necrosis factor receptor member 16 trans-membrane domain Complex1_LYR PF05347.15 AET39430.1 - 3.3e-15 55.9 0.5 3.9e-15 55.6 0.5 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 AET39430.1 - 0.006 17.3 0.2 0.0068 17.1 0.2 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 AET39430.1 - 0.029 15.0 0.0 0.034 14.8 0.0 1.2 1 0 0 1 1 1 0 Complex1_LYR-like Ofd1_CTDD PF10637.9 AET39431.1 - 1.2e-87 293.5 0.4 1.8e-86 289.7 0.3 2.1 2 0 0 2 2 2 1 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 AET39431.1 - 2e-26 92.5 0.0 5e-26 91.2 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 AET39431.1 - 7.5e-15 55.6 0.2 3.6e-14 53.4 0.1 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 AET39431.1 - 0.039 14.4 0.1 0.11 13.0 0.1 1.8 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily BAR_2 PF10455.9 AET39432.1 - 1.2e-71 241.2 16.0 1.2e-71 241.2 16.0 2.1 2 1 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 AET39432.1 - 2.4e-13 50.3 13.2 2.4e-13 50.3 13.2 2.8 1 1 1 2 2 2 1 BAR domain ATP-synt_ab PF00006.25 AET39432.1 - 0.015 14.9 0.5 0.032 13.9 0.2 1.8 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Macscav_rec PF03523.13 AET39432.1 - 0.46 10.4 3.6 3.5 7.6 1.3 3.3 2 1 0 2 2 2 0 Macrophage scavenger receptor DUF1090 PF06476.12 AET39432.1 - 4 7.6 9.9 25 5.0 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1090) YtxH PF12732.7 AET39432.1 - 6.7 7.3 10.3 21 5.7 3.2 3.7 2 2 0 2 2 2 0 YtxH-like protein BCDHK_Adom3 PF10436.9 AET39433.1 - 3.2e-22 79.1 0.2 5e-22 78.5 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 AET39433.1 - 2.2e-15 57.1 0.0 5.1e-15 55.9 0.0 1.6 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 AET39433.1 - 0.0014 18.5 0.0 0.0024 17.7 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_S18 PF01084.20 AET39434.1 - 7.6e-20 70.9 0.0 1.6e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S18 Tim44 PF04280.15 AET39435.1 - 7.4e-37 126.7 0.0 1.6e-36 125.6 0.0 1.6 1 0 0 1 1 1 1 Tim44-like domain RNA_pol_A_bac PF01000.26 AET39437.1 - 7.3e-33 113.3 0.4 4.4e-32 110.8 0.1 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 AET39437.1 - 7.7e-19 66.9 0.0 1e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain His_biosynth PF00977.21 AET39438.1 - 2.8e-22 79.3 0.0 3.3e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 Histidine biosynthesis protein Dynein_heavy PF03028.15 AET39438.1 - 0.14 12.3 0.2 1.8 8.6 0.0 2.4 2 1 1 3 3 3 0 Dynein heavy chain region D6 P-loop domain DUF4602 PF15375.6 AET39439.1 - 3.9 7.8 24.1 2.3 8.6 14.4 4.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4602) Secretin_N_2 PF07655.13 AET39439.1 - 5.5 7.6 9.2 14 6.3 2.5 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain HLH PF00010.26 AET39440.1 - 1.1e-13 50.9 0.1 2.3e-13 49.9 0.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF2423 PF10338.9 AET39440.1 - 0.012 15.8 2.6 0.024 14.9 2.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2423) UCR_hinge PF02320.16 AET39441.1 - 1.9e-25 88.8 4.6 3.9e-25 87.8 4.6 1.5 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein Nop14 PF04147.12 AET39441.1 - 0.00082 17.7 19.5 0.00097 17.5 19.5 1.0 1 0 0 1 1 1 1 Nop14-like family DNA_pol_phi PF04931.13 AET39441.1 - 0.0013 16.9 27.9 0.0015 16.7 27.9 1.1 1 0 0 1 1 1 1 DNA polymerase phi Sigma70_ner PF04546.13 AET39441.1 - 0.0047 16.8 16.4 0.007 16.3 16.4 1.3 1 0 0 1 1 1 1 Sigma-70, non-essential region PPL5 PF18168.1 AET39441.1 - 0.0054 16.1 0.7 0.0067 15.8 0.7 1.1 1 0 0 1 1 1 1 Prim-pol family 5 RRN3 PF05327.11 AET39441.1 - 0.0063 15.1 18.7 0.0072 14.9 18.7 1.1 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 RPN2_C PF18004.1 AET39441.1 - 0.0082 16.1 4.5 0.012 15.6 4.5 1.2 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain SAPS PF04499.15 AET39441.1 - 0.0083 15.0 4.9 0.0091 14.8 4.9 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein SGT1 PF07093.11 AET39441.1 - 0.011 14.2 9.0 0.012 14.0 9.0 1.1 1 0 0 1 1 1 0 SGT1 protein Cwf_Cwc_15 PF04889.12 AET39441.1 - 0.028 14.2 23.2 0.038 13.7 23.2 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 AET39441.1 - 0.037 12.3 15.0 0.041 12.2 15.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Mpp10 PF04006.12 AET39441.1 - 0.051 12.0 19.3 0.059 11.8 19.3 1.0 1 0 0 1 1 1 0 Mpp10 protein Paf1 PF03985.13 AET39441.1 - 0.062 12.3 12.9 0.087 11.8 12.9 1.2 1 0 0 1 1 1 0 Paf1 CobT PF06213.12 AET39441.1 - 0.08 12.3 15.2 0.09 12.2 15.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Vfa1 PF08432.10 AET39441.1 - 0.12 12.7 8.6 0.16 12.3 8.6 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Cnd2 PF05786.14 AET39441.1 - 0.18 10.4 11.9 0.19 10.3 11.9 1.0 1 0 0 1 1 1 0 Condensin complex subunit 2 RNA_pol_Rpc4 PF05132.14 AET39441.1 - 0.19 12.2 2.6 0.25 11.7 2.6 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 FYDLN_acid PF09538.10 AET39441.1 - 0.22 12.2 24.8 0.42 11.3 24.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF3381 PF11861.8 AET39441.1 - 0.24 11.2 16.0 0.13 12.0 12.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) NOA36 PF06524.12 AET39441.1 - 0.26 10.6 23.3 0.39 10.0 23.3 1.3 1 0 0 1 1 1 0 NOA36 protein DUF913 PF06025.12 AET39441.1 - 0.28 10.1 3.2 0.32 9.9 3.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PDDEXK_6 PF04720.12 AET39441.1 - 0.3 11.0 8.4 0.43 10.5 8.4 1.2 1 0 0 1 1 1 0 PDDEXK-like family of unknown function LAP1C PF05609.12 AET39441.1 - 0.34 10.0 9.3 0.39 9.7 9.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) BUD22 PF09073.10 AET39441.1 - 0.4 10.0 19.0 0.46 9.8 19.0 1.1 1 0 0 1 1 1 0 BUD22 Sporozoite_P67 PF05642.11 AET39441.1 - 0.66 8.0 10.0 0.75 7.8 10.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Afi1 PF07792.12 AET39441.1 - 0.72 10.3 12.0 1 9.9 12.0 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Nop53 PF07767.11 AET39441.1 - 0.72 9.2 12.7 0.85 8.9 12.7 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Tom22 PF04281.13 AET39441.1 - 1 9.2 20.5 1.7 8.4 20.5 1.3 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 SDA1 PF05285.12 AET39441.1 - 1.1 8.6 23.2 1.3 8.3 23.2 1.1 1 0 0 1 1 1 0 SDA1 Dicty_REP PF05086.12 AET39441.1 - 1.6 6.6 16.9 2.2 6.1 16.9 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Tim54 PF11711.8 AET39441.1 - 2.8 6.6 6.6 3.4 6.4 6.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 IFT57 PF10498.9 AET39441.1 - 3.2 6.6 13.4 4.1 6.3 13.4 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Utp14 PF04615.13 AET39441.1 - 3.9 5.9 16.5 5.3 5.5 16.5 1.2 1 0 0 1 1 1 0 Utp14 protein Pes-10 PF07149.11 AET39441.1 - 4.1 6.4 16.6 5 6.1 16.6 1.3 1 0 0 1 1 1 0 Pes-10 PPP4R2 PF09184.11 AET39441.1 - 5.2 6.6 19.2 7.1 6.1 19.2 1.3 1 0 0 1 1 1 0 PPP4R2 V_ATPase_I PF01496.19 AET39441.1 - 6.8 4.5 6.2 8.7 4.1 6.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TRAP_alpha PF03896.16 AET39441.1 - 7.4 5.7 15.3 9.7 5.3 15.3 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2722 PF10846.8 AET39441.1 - 8.8 5.1 13.0 11 4.9 13.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Ribosomal_L29e PF01779.17 AET39442.1 - 7.6e-23 80.6 10.6 9.9e-23 80.2 10.6 1.2 1 0 0 1 1 1 1 Ribosomal L29e protein family Ribosomal_L2_C PF03947.18 AET39443.1 - 6e-44 149.3 3.6 1.1e-43 148.5 3.6 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 AET39443.1 - 1.5e-13 50.5 0.1 4.1e-13 49.1 0.1 1.8 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain SMC_N PF02463.19 AET39444.1 - 2e-71 239.9 1.3 1.3e-70 237.3 1.3 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 AET39444.1 - 1.3e-17 64.2 0.8 2.8e-17 63.1 0.1 2.0 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 AET39444.1 - 8.1e-08 32.4 11.1 0.00038 20.4 0.2 3.5 3 2 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 AET39444.1 - 1.2e-07 31.8 20.8 1.2e-07 31.8 20.8 4.6 2 2 1 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 AET39444.1 - 0.00043 20.0 0.1 0.0013 18.4 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain Fez1 PF06818.15 AET39444.1 - 0.0017 18.9 14.5 0.0017 18.9 14.5 5.6 2 2 3 5 5 5 2 Fez1 MscS_porin PF12795.7 AET39444.1 - 0.0042 16.7 34.8 0.0064 16.1 16.0 6.9 4 2 3 7 7 7 3 Mechanosensitive ion channel porin domain GAS PF13851.6 AET39444.1 - 0.0048 16.3 8.7 0.0048 16.3 8.7 7.5 3 2 4 7 7 7 2 Growth-arrest specific micro-tubule binding DUF4407 PF14362.6 AET39444.1 - 0.64 9.3 63.6 0.071 12.4 7.6 5.3 2 2 3 5 5 5 0 Domain of unknown function (DUF4407) FAD_binding_1 PF00667.20 AET39445.1 - 2.1e-65 220.4 0.0 4.2e-65 219.4 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 AET39445.1 - 5.4e-08 33.5 0.0 1.1e-07 32.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain POR PF01558.18 AET39445.1 - 0.0047 17.0 0.0 0.01 15.9 0.0 1.5 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase HEAT PF02985.22 AET39446.1 - 0.027 14.7 0.0 0.5 10.8 0.0 2.8 2 0 0 2 2 2 0 HEAT repeat BAG PF02179.16 AET39447.1 - 4.8e-16 59.0 2.5 1e-15 57.9 2.5 1.6 1 0 0 1 1 1 1 BAG domain SNN_transmemb PF09049.10 AET39447.1 - 0.29 11.1 1.4 0.53 10.3 1.4 1.4 1 0 0 1 1 1 0 Stannin transmembrane Asp PF00026.23 AET39448.1 - 7.8e-66 222.6 0.1 7.8e-66 222.6 0.1 1.5 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AET39448.1 - 7.7e-13 49.1 0.0 3.3e-12 47.0 0.1 2.0 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 AET39448.1 - 0.0013 19.3 4.7 0.16 12.6 0.0 3.8 4 0 0 4 4 4 1 Aspartyl protease gag-asp_proteas PF13975.6 AET39448.1 - 0.047 14.3 3.0 0.57 10.8 0.0 3.4 4 0 0 4 4 4 0 gag-polyprotein putative aspartyl protease Lum_binding PF00677.17 AET39449.1 - 3.3e-43 145.6 1.6 7.8e-22 77.1 0.1 2.2 2 0 0 2 2 2 2 Lumazine binding domain ANAPC4_WD40 PF12894.7 AET39450.1 - 1.8e-07 31.3 2.1 0.00039 20.7 0.2 4.1 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 AET39450.1 - 0.0032 17.3 0.0 0.16 12.0 0.0 2.9 2 0 0 2 2 2 1 PQQ enzyme repeat WD40 PF00400.32 AET39450.1 - 0.016 16.1 8.9 38 5.4 0.0 5.8 7 0 0 7 7 7 0 WD domain, G-beta repeat RAB3GAP2_N PF14655.6 AET39450.1 - 0.017 14.4 0.1 0.096 11.9 0.1 1.9 1 1 1 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus PQQ_3 PF13570.6 AET39450.1 - 0.067 13.7 0.6 32 5.2 0.0 3.5 3 0 0 3 3 3 0 PQQ-like domain PQQ_2 PF13360.6 AET39450.1 - 0.1 12.1 0.0 19 4.7 0.0 3.0 2 1 0 2 2 2 0 PQQ-like domain Cut8 PF08559.10 AET39451.1 - 1.5e-66 224.5 0.0 1.7e-66 224.3 0.0 1.1 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein DUF19 PF01579.18 AET39453.1 - 0.62 9.8 5.7 1.3 8.8 3.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF19) Sedlin_N PF04628.13 AET39454.1 - 9.4e-53 177.8 0.7 1.2e-52 177.4 0.7 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 AET39454.1 - 1.3e-05 25.2 0.4 2.9e-05 24.0 0.2 1.7 2 0 0 2 2 2 1 Sybindin-like family MIS13 PF08202.11 AET39455.1 - 1.2e-66 225.0 6.0 1.2e-66 225.0 6.0 1.7 2 0 0 2 2 2 1 Mis12-Mtw1 protein family Med22 PF06179.12 AET39456.1 - 5.4e-20 71.6 0.6 7.4e-20 71.1 0.6 1.2 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex dUTPase PF00692.19 AET39457.1 - 8.9e-46 154.8 0.0 1e-45 154.6 0.0 1.0 1 0 0 1 1 1 1 dUTPase Peptidase_M16 PF00675.20 AET39458.1 - 5e-31 107.7 0.2 1.5e-30 106.1 0.2 1.8 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 AET39458.1 - 2.5e-18 66.4 0.2 7.6e-18 64.8 0.0 2.0 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 AET39458.1 - 8.1e-09 35.7 0.1 2e-06 27.9 0.0 3.3 3 0 0 3 3 3 1 Peptidase M16 inactive domain Rrp15p PF07890.12 AET39459.1 - 1.9e-31 109.1 11.9 1.9e-31 109.1 11.9 1.8 3 0 0 3 3 3 1 Rrp15p Kinesin PF00225.23 AET39460.1 - 1.4e-100 336.5 2.8 3.2e-100 335.3 2.8 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 AET39460.1 - 1.7e-54 183.8 0.1 6e-54 182.0 0.1 2.0 1 0 0 1 1 1 1 Microtubule binding PhoH PF02562.16 AET39460.1 - 0.03 13.8 1.6 0.51 9.8 0.1 3.1 2 1 0 2 2 2 0 PhoH-like protein Acyltransferase PF01553.21 AET39461.1 - 2.1e-17 63.0 0.0 4e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase PaaX_C PF08223.11 AET39461.1 - 0.037 14.3 0.1 0.077 13.3 0.1 1.5 1 0 0 1 1 1 0 PaaX-like protein C-terminal domain Ammonium_transp PF00909.21 AET39463.1 - 3.1e-116 388.4 25.5 3.6e-116 388.1 25.5 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family PAP2_3 PF14378.6 AET39463.1 - 0.017 14.8 9.3 0.053 13.2 0.6 3.6 3 1 1 4 4 4 0 PAP2 superfamily Metallophos PF00149.28 AET39464.1 - 5.4e-32 112.0 0.1 8.1e-32 111.4 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 AET39464.1 - 3.4e-16 59.3 0.0 1.1e-15 57.7 0.0 1.9 2 1 1 3 3 3 1 PPP5 TPR repeat region TPR_1 PF00515.28 AET39464.1 - 1.1e-12 47.2 0.6 0.00053 19.7 0.4 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 AET39464.1 - 1.3e-11 43.6 0.7 0.011 15.8 0.2 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 AET39464.1 - 1.9e-09 37.0 0.2 0.00026 20.6 0.1 2.7 1 1 1 2 2 2 2 TPR repeat TPR_8 PF13181.6 AET39464.1 - 2.6e-08 33.4 0.2 0.12 12.7 0.1 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.6 AET39464.1 - 5.7e-05 23.2 0.9 0.001 19.2 0.1 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 AET39464.1 - 0.00073 19.8 0.1 0.99 9.9 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 AET39464.1 - 0.023 15.0 0.6 7.5 6.9 0.1 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TRAM_LAG1_CLN8 PF03798.16 AET39465.1 - 5.1e-26 91.6 19.1 5.1e-26 91.6 19.1 1.4 2 0 0 2 2 2 1 TLC domain Flavin_Reduct PF01613.18 AET39466.1 - 6.3e-25 88.0 0.4 3.3e-24 85.7 0.4 1.8 1 1 0 1 1 1 1 Flavin reductase like domain RRG8 PF17068.5 AET39467.1 - 1.8e-73 247.4 0.7 2.1e-73 247.1 0.7 1.0 1 0 0 1 1 1 1 Required for respiratory growth protein 8 mitochondrial Telomere_reg-2 PF10193.9 AET39468.1 - 9.5e-23 80.7 0.7 9.5e-23 80.7 0.7 2.7 2 1 0 2 2 2 1 Telomere length regulation protein Rhomboid PF01694.22 AET39469.1 - 5.6e-31 107.6 19.0 6.7e-31 107.3 17.5 1.8 2 0 0 2 2 2 1 Rhomboid family Glu-tRNAGln PF02686.15 AET39470.1 - 0.053 13.8 0.4 0.14 12.4 0.1 2.0 2 1 0 2 2 2 0 Glu-tRNAGln amidotransferase C subunit Pescadillo_N PF06732.11 AET39471.1 - 1.2e-119 398.9 0.7 1.2e-119 398.9 0.7 2.1 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 AET39471.1 - 2.3e-10 40.7 0.0 5.5e-10 39.5 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 AET39471.1 - 0.0025 18.2 0.0 0.0073 16.7 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Med18 PF09637.10 AET39472.1 - 2.8e-58 197.7 0.1 3.1e-58 197.5 0.1 1.0 1 0 0 1 1 1 1 Med18 protein VMA21 PF09446.10 AET39473.1 - 9.7e-10 38.4 15.7 9.3e-09 35.3 15.7 1.9 1 1 0 1 1 1 1 VMA21-like domain PqiA PF04403.13 AET39473.1 - 0.037 13.9 2.8 0.043 13.6 2.8 1.0 1 0 0 1 1 1 0 Paraquat-inducible protein A DUF1430 PF07242.11 AET39473.1 - 0.12 12.6 2.3 0.15 12.4 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1430) LptF_LptG PF03739.14 AET39473.1 - 0.36 9.6 3.3 0.37 9.6 3.3 1.0 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG ATP-synt_S1 PF05827.12 AET39474.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 Vacuolar ATP synthase subunit S1 (ATP6S1) IF-2B PF01008.17 AET39475.1 - 1.8e-80 270.2 0.0 2.2e-80 269.9 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Cyclin_N PF00134.23 AET39476.1 - 6.7e-40 135.8 0.1 1.8e-39 134.4 0.1 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 AET39476.1 - 7.7e-30 103.4 0.0 7.7e-30 103.4 0.0 2.7 3 0 0 3 3 3 1 Cyclin, C-terminal domain Cyclin_N PF00134.23 AET39477.1 - 2.9e-37 127.3 1.7 2.9e-37 127.3 1.7 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 AET39477.1 - 7.1e-15 55.1 0.1 7.1e-15 55.1 0.1 2.2 3 0 0 3 3 3 1 Cyclin, C-terminal domain Sporozoite_P67 PF05642.11 AET39477.1 - 0.41 8.7 6.4 0.66 8.0 6.4 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CAML PF14963.6 AET39477.1 - 3 7.9 5.7 4.5 7.3 5.7 1.3 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand RR_TM4-6 PF06459.12 AET39477.1 - 6.8 6.4 9.4 10 5.8 9.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MTBP_C PF14920.6 AET39477.1 - 8.8 6.0 14.5 18 5.0 0.1 2.2 2 0 0 2 2 2 0 MDM2-binding WD40 PF00400.32 AET39479.1 - 1.2e-18 67.1 0.4 2.4e-05 25.0 0.0 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 AET39479.1 - 0.01 14.4 1.0 0.18 10.3 0.2 2.5 2 1 0 2 2 2 0 Cytochrome D1 heme domain WD40_like PF17005.5 AET39479.1 - 0.012 14.9 0.0 0.25 10.7 0.0 2.4 2 0 0 2 2 2 0 WD40-like domain ANAPC4_WD40 PF12894.7 AET39479.1 - 0.018 15.4 0.1 0.74 10.1 0.0 3.2 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Mcl1_mid PF12341.8 AET39480.1 - 2.5e-85 286.4 0.0 1.8e-84 283.6 0.0 2.1 2 0 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 PF12894.7 AET39480.1 - 0.00097 19.4 0.0 5 7.5 0.0 3.6 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain COG2 PF06148.11 AET39481.1 - 8.1e-11 42.1 4.7 2.1e-10 40.8 3.9 1.9 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Syntaxin_2 PF14523.6 AET39481.1 - 0.0097 16.3 5.9 5.8 7.3 1.7 4.1 1 1 1 2 2 2 2 Syntaxin-like protein Ribosomal_L29 PF00831.23 AET39481.1 - 0.021 14.8 0.4 5.6 7.0 0.1 2.7 2 0 0 2 2 2 0 Ribosomal L29 protein Mating_N PF12731.7 AET39481.1 - 0.048 13.7 4.0 0.095 12.8 1.8 2.3 2 0 0 2 2 2 0 Mating-type protein beta 1 Mst1_SARAH PF11629.8 AET39481.1 - 0.11 12.5 0.6 0.88 9.7 0.4 2.5 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 Importin_rep_2 PF18786.1 AET39481.1 - 0.21 11.5 2.7 1.4 8.8 0.1 2.9 2 0 0 2 2 2 0 Importin 13 repeat Nup54 PF13874.6 AET39482.1 - 1.8e-36 125.3 4.1 1.8e-36 125.3 4.1 2.9 3 0 0 3 3 1 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.6 AET39482.1 - 6.9e-06 26.8 77.1 0.00014 22.6 38.4 5.2 1 1 3 4 4 3 2 Nucleoporin FG repeat region SpoIIP PF07454.11 AET39482.1 - 0.055 12.9 13.8 0.098 12.1 13.8 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Ndc1_Nup PF09531.10 AET39482.1 - 0.086 11.5 12.1 0.11 11.2 12.1 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RR_TM4-6 PF06459.12 AET39482.1 - 0.13 12.1 13.3 0.24 11.2 13.3 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 eIF-3_zeta PF05091.12 AET39482.1 - 0.31 10.0 23.8 0.46 9.4 23.8 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EOS1 PF12326.8 AET39482.1 - 0.41 10.6 5.7 0.91 9.4 5.7 1.6 1 0 0 1 1 1 0 N-glycosylation protein TERB2 PF15101.6 AET39482.1 - 0.78 9.8 21.4 1.7 8.7 21.4 1.6 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Presenilin PF01080.17 AET39482.1 - 1.1 7.9 19.6 1.6 7.4 19.6 1.2 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 AET39482.1 - 1.6 7.5 15.1 2.5 6.8 15.1 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 FAM176 PF14851.6 AET39482.1 - 3.7 7.2 9.0 8 6.1 9.0 1.6 1 0 0 1 1 1 0 FAM176 family PAT1 PF09770.9 AET39482.1 - 4 5.6 42.1 5.6 5.1 42.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Connexin PF00029.19 AET39482.1 - 5.2 6.8 11.2 8.7 6.0 11.2 1.3 1 0 0 1 1 1 0 Connexin GOLD_2 PF13897.6 AET39482.1 - 5.4 7.5 5.4 11 6.5 5.4 1.5 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking AIF_C PF14721.6 AET39482.1 - 5.4 7.4 12.8 14 6.1 12.8 1.7 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RED_N PF07808.13 AET39482.1 - 5.7 6.5 22.4 12 5.4 22.4 1.5 1 0 0 1 1 1 0 RED-like protein N-terminal region Folate_carrier PF01770.18 AET39482.1 - 5.8 5.5 11.5 8.8 4.9 11.5 1.1 1 0 0 1 1 1 0 Reduced folate carrier PRC2_HTH_1 PF18118.1 AET39482.1 - 6.9 7.5 13.2 20 6.1 13.2 1.7 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain CobT PF06213.12 AET39482.1 - 8.2 5.7 24.4 16 4.8 24.4 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Cyclin PF08613.11 AET39482.1 - 8.4 6.7 7.9 18 5.7 7.9 1.5 1 0 0 1 1 1 0 Cyclin CPSF100_C PF13299.6 AET39482.1 - 8.7 6.5 14.3 19 5.4 14.3 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Tom5 PF10642.9 AET39484.1 - 5.3e-20 71.2 0.3 5.7e-20 71.1 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase Med26 PF08711.11 AET39485.1 - 3.2e-13 49.5 0.6 4.1e-12 45.9 0.0 2.6 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Phasin PF05597.11 AET39485.1 - 0.77 9.8 8.2 0.11 12.5 1.5 2.5 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Ribosom_S12_S23 PF00164.25 AET39486.1 - 4.6e-52 174.5 0.4 5.8e-52 174.1 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Acetyltransf_1 PF00583.25 AET39488.1 - 3.2e-08 33.8 0.0 4.4e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AET39488.1 - 2.4e-05 24.7 0.0 3.5e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AET39488.1 - 4.1e-05 23.5 0.0 6.2e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AET39488.1 - 0.00011 22.1 0.0 0.00019 21.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 AET39488.1 - 0.02 15.0 0.0 0.028 14.5 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain LSM14 PF12701.7 AET39489.1 - 4.3e-26 90.8 0.0 7.6e-26 90.0 0.0 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 AET39489.1 - 1.3e-07 32.4 15.6 9.7e-06 26.4 15.6 2.5 1 1 0 1 1 1 1 FDF domain SM-ATX PF14438.6 AET39489.1 - 8.9e-06 25.8 0.0 2e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain Mito_carr PF00153.27 AET39490.1 - 6.1e-51 170.3 5.4 9.6e-19 67.1 0.1 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein HSP90 PF00183.18 AET39490.1 - 0.25 10.2 0.3 0.9 8.4 0.1 1.8 2 0 0 2 2 2 0 Hsp90 protein RRM_1 PF00076.22 AET39491.1 - 2.1e-70 232.5 11.8 1.7e-17 63.0 0.1 6.2 5 1 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AET39491.1 - 1.4e-06 28.0 0.0 0.48 10.3 0.0 4.9 5 1 0 5 5 5 2 Occluded RNA-recognition motif RRM_5 PF13893.6 AET39491.1 - 2.4e-06 27.1 0.0 0.0018 17.9 0.0 3.9 4 1 1 5 5 5 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AET39491.1 - 0.00038 20.5 0.3 5 7.3 0.0 4.6 5 0 0 5 5 5 2 RNA recognition motif Nup35_RRM_2 PF14605.6 AET39491.1 - 0.00088 19.2 0.1 3.2 7.8 0.0 3.7 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 AET39491.1 - 0.017 15.2 0.1 35 4.6 0.0 4.3 5 0 0 5 5 5 0 Limkain b1 CwfJ_C_1 PF04677.15 AET39492.1 - 4.4e-31 107.3 0.9 9.2e-31 106.3 0.9 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 AET39492.1 - 5.6e-17 62.5 2.8 2.3e-16 60.5 1.6 2.4 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 PFU PF09070.11 AET39492.1 - 0.065 13.5 0.0 0.52 10.6 0.0 2.4 2 0 0 2 2 2 0 PFU (PLAA family ubiquitin binding) Zap1_zf2 PF18217.1 AET39492.1 - 0.094 12.7 0.2 0.31 11.1 0.2 1.9 1 0 0 1 1 1 0 Zap1 zinc finger 2 Pkinase PF00069.25 AET39493.1 - 3.3e-56 190.6 0.0 2e-55 188.0 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET39493.1 - 6.3e-28 97.8 0.1 9.8e-19 67.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 AET39493.1 - 4.7e-05 22.5 0.6 9.5e-05 21.5 0.6 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_C PF00433.24 AET39493.1 - 0.00066 20.3 0.9 0.002 18.8 0.9 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 AET39493.1 - 0.0012 18.2 0.0 0.013 14.9 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 AET39493.1 - 0.019 14.3 0.0 0.045 13.1 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AET39493.1 - 0.084 12.8 0.0 0.35 10.8 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Nop PF01798.18 AET39494.1 - 2.6e-61 207.0 0.6 4.5e-61 206.2 0.6 1.4 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 AET39494.1 - 7.8e-24 84.9 3.3 1.6e-23 83.9 3.3 1.6 1 0 0 1 1 1 1 Prp31 C terminal domain RNA_pol_A_bac PF01000.26 AET39495.1 - 1.3e-28 99.6 0.0 3.1e-28 98.4 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 AET39495.1 - 2.5e-21 74.9 0.0 3.4e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DUF1746 PF08508.10 AET39496.1 - 8.8e-06 26.0 0.7 0.0002 21.7 0.7 2.6 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1746) Nrap_D5 PF17406.2 AET39497.1 - 1.1e-52 178.0 0.0 2.2e-52 177.1 0.0 1.5 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D2 PF17403.2 AET39497.1 - 8.4e-49 165.2 0.7 4.1e-46 156.5 0.1 3.0 3 0 0 3 3 3 2 Nrap protein PAP/OAS-like domain Nrap_D4 PF17405.2 AET39497.1 - 2.9e-47 160.8 0.1 4.6e-47 160.1 0.1 1.3 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap PF03813.14 AET39497.1 - 1.4e-43 148.5 4.2 1.7e-43 148.3 0.8 2.4 2 0 0 2 2 2 1 Nrap protein domain 1 Nrap_D3 PF17404.2 AET39497.1 - 1.1e-39 136.1 0.0 2.1e-39 135.2 0.0 1.5 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 AET39497.1 - 3.8e-30 104.9 0.2 1e-29 103.4 0.2 1.8 1 0 0 1 1 1 1 Nrap protein domain 6 T3SS_needle_F PF09392.10 AET39498.1 - 2.4 8.4 6.3 0.64 10.2 1.5 2.5 2 0 0 2 2 2 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF EMP24_GP25L PF01105.24 AET39499.1 - 2.1e-35 122.3 0.4 2.4e-35 122.1 0.4 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2569 PF10754.9 AET39499.1 - 0.042 14.3 0.2 0.078 13.4 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) Herpes_BTRF1 PF04682.12 AET39499.1 - 0.11 11.9 0.1 0.16 11.3 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus BTRF1 protein conserved region TP6A_N PF04406.14 AET39500.1 - 3.6e-14 52.5 1.1 3.6e-14 52.5 1.1 2.0 2 0 0 2 2 2 1 Type IIB DNA topoisomerase E3_UbLigase_EDD PF11547.8 AET39500.1 - 0.0087 15.7 0.3 0.025 14.3 0.3 1.7 1 0 0 1 1 1 1 E3 ubiquitin ligase EDD DUF2399 PF09664.10 AET39500.1 - 0.052 13.5 0.0 0.083 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2399) TauD PF02668.16 AET39501.1 - 1.5e-44 152.8 0.0 2.2e-44 152.3 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 AET39501.1 - 0.00066 20.3 0.0 0.0019 18.8 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.10 AET39501.1 - 0.1 11.7 0.0 0.23 10.5 0.0 1.5 1 0 0 1 1 1 0 CsiD Pet127 PF08634.10 AET39502.1 - 1.9e-108 362.1 0.6 2.9e-108 361.5 0.6 1.3 1 0 0 1 1 1 1 Mitochondrial protein Pet127 PQ-loop PF04193.14 AET39503.1 - 3e-10 39.7 14.2 9.5e-09 34.9 1.6 3.7 3 1 1 4 4 4 2 PQ loop repeat Rhomboid PF01694.22 AET39503.1 - 3.4 7.6 9.7 0.73 9.8 0.5 2.8 3 0 0 3 3 3 0 Rhomboid family ARD PF03079.14 AET39504.1 - 1.9e-44 151.6 1.2 2.1e-44 151.4 1.2 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 AET39504.1 - 5.4e-10 38.9 0.1 9.2e-10 38.1 0.1 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 AET39504.1 - 4.4e-08 33.1 0.0 6e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 AET39504.1 - 0.00059 19.5 0.0 0.00083 19.0 0.0 1.2 1 0 0 1 1 1 1 Cupin JmjC PF02373.22 AET39504.1 - 0.07 13.6 0.0 0.19 12.2 0.0 1.7 1 1 0 1 1 1 0 JmjC domain, hydroxylase Cupin_3 PF05899.12 AET39504.1 - 0.072 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Cupin_8 PF13621.6 AET39504.1 - 0.088 12.5 0.1 0.41 10.3 0.0 1.8 1 1 0 2 2 2 0 Cupin-like domain SRP1_TIP1 PF00660.17 AET39505.1 - 1.2e-33 115.1 0.3 1.8e-33 114.5 0.3 1.2 1 0 0 1 1 1 1 Seripauperin and TIP1 family Apt1 PF10351.9 AET39505.1 - 2 7.2 13.4 2.4 6.9 13.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOG2 PF10428.9 AET39505.1 - 2.5 7.2 17.2 2.7 7.1 17.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Plasmodium_Vir PF05795.11 AET39505.1 - 2.5 7.4 5.9 3.4 7.0 5.9 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein EF-hand_4 PF12763.7 AET39506.1 - 5.4e-25 87.4 0.0 1.1e-12 47.8 0.0 2.7 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand DUF1720 PF08226.11 AET39506.1 - 6.8e-09 36.0 57.9 1.1e-06 29.0 32.6 9.8 5 2 3 8 8 8 3 Domain of unknown function (DUF1720) EF-hand_1 PF00036.32 AET39506.1 - 3.9e-08 32.3 0.0 0.0013 18.1 0.0 3.7 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 AET39506.1 - 1e-07 32.3 0.0 0.0026 18.2 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AET39506.1 - 2.3e-06 27.1 0.1 0.1 12.6 0.0 4.6 4 0 0 4 4 4 1 EF-hand domain DUF4407 PF14362.6 AET39506.1 - 0.0017 17.8 1.3 0.0017 17.8 1.3 4.0 2 2 1 3 3 3 1 Domain of unknown function (DUF4407) NBD94 PF16830.5 AET39506.1 - 0.065 13.6 2.9 4.6 7.7 1.1 2.8 2 0 0 2 2 2 0 Nucleotide-Binding Domain 94 of RH EF-hand_8 PF13833.6 AET39506.1 - 0.15 11.9 0.0 0.46 10.4 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain pair E3_binding PF02817.17 AET39506.1 - 0.2 12.1 0.0 0.45 10.9 0.0 1.6 1 0 0 1 1 1 0 e3 binding domain RRM_1 PF00076.22 AET39507.1 - 1e-15 57.3 0.0 1.7e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RraA-like PF03737.15 AET39508.1 - 2e-32 112.4 0.0 2.6e-32 112.1 0.0 1.1 1 0 0 1 1 1 1 Aldolase/RraA ILEI PF15711.5 AET39508.1 - 0.012 16.1 0.1 4.8 7.7 0.0 2.3 2 0 0 2 2 2 0 Interleukin-like EMT inducer DnaJ-X PF14308.6 AET39509.1 - 4.6e-76 255.0 1.1 4.6e-76 255.0 1.1 2.7 1 1 1 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 AET39509.1 - 4.6e-23 81.1 1.5 4.6e-23 81.1 1.5 2.4 2 0 0 2 2 2 1 DnaJ domain DUF4532 PF15046.6 AET39509.1 - 0.015 14.5 0.0 0.027 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4532) PSD5 PF07637.11 AET39509.1 - 0.041 14.2 0.1 0.13 12.6 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1595) WDCP PF15390.6 AET39509.1 - 0.18 10.1 5.8 0.26 9.6 5.8 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family CDC45 PF02724.14 AET39509.1 - 1.4 7.1 12.7 1.7 6.9 10.1 1.9 2 0 0 2 2 2 0 CDC45-like protein DUF4661 PF15576.6 AET39509.1 - 4.5 7.1 8.3 10 6.0 8.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) Presenilin PF01080.17 AET39509.1 - 5 5.8 11.5 7.9 5.1 11.5 1.3 1 0 0 1 1 1 0 Presenilin Dsh_C PF12316.8 AET39509.1 - 5.3 7.4 8.5 8.4 6.7 8.5 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Aim21 PF11489.8 AET39510.1 - 1.8e-19 70.2 11.6 1.8e-19 70.2 11.6 3.8 4 0 0 4 4 4 2 Altered inheritance of mitochondria protein 21 Lant_dehydr_C PF14028.6 AET39510.1 - 0.26 10.8 0.8 0.43 10.1 0.8 1.2 1 0 0 1 1 1 0 Lantibiotic biosynthesis dehydratase C-term DNA_ligase_A_C PF04679.15 AET39510.1 - 0.9 10.2 0.0 0.9 10.2 0.0 2.7 3 0 0 3 3 3 0 ATP dependent DNA ligase C terminal region NTF2 PF02136.20 AET39511.1 - 1.7e-36 125.4 0.5 1.9e-36 125.2 0.5 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4518 PF15008.6 AET39511.1 - 0.00062 19.0 0.1 0.0015 17.8 0.1 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4518) DUF4440 PF14534.6 AET39511.1 - 0.13 12.6 0.0 0.17 12.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Omp28 PF11551.8 AET39511.1 - 0.15 11.9 0.0 0.19 11.6 0.0 1.1 1 0 0 1 1 1 0 Outer membrane protein Omp28 Sec3_C PF09763.9 AET39512.1 - 5.9e-171 570.4 25.2 8.9e-171 569.8 25.2 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 AET39512.1 - 8.6e-25 86.7 1.0 8.6e-25 86.7 1.0 2.6 3 1 0 3 3 3 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Vps52 PF04129.12 AET39512.1 - 1.8e-11 43.5 5.0 1.8e-11 43.5 5.0 2.0 3 0 0 3 3 3 1 Vps52 / Sac2 family THOC7 PF05615.13 AET39512.1 - 0.024 14.9 5.7 1.4 9.2 0.5 3.1 1 1 1 2 2 2 0 Tho complex subunit 7 Sec3_C_2 PF15278.6 AET39512.1 - 0.024 15.0 0.0 0.096 13.0 0.0 2.2 1 0 0 1 1 1 0 Sec3 exocyst complex subunit K-box PF01486.17 AET39512.1 - 0.097 12.9 2.6 0.13 12.4 0.7 2.3 2 0 0 2 2 2 0 K-box region HD_3 PF13023.6 AET39512.1 - 0.13 12.2 0.7 1.2 9.1 0.0 2.6 3 0 0 3 3 3 0 HD domain ResIII PF04851.15 AET39513.1 - 5.6e-21 75.3 0.0 5.6e-21 75.3 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 AET39513.1 - 2e-20 73.2 0.6 1.6e-19 70.2 0.2 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 AET39513.1 - 3.1e-19 69.4 0.1 2.3e-18 66.6 0.0 2.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase SNF2_N PF00176.23 AET39513.1 - 1.7e-05 23.7 0.1 3.1e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain SWI2_SNF2 PF18766.1 AET39513.1 - 5.7e-05 22.9 0.1 5.7e-05 22.9 0.1 1.9 2 0 0 2 2 2 1 SWI2/SNF2 ATPase PhoH PF02562.16 AET39513.1 - 0.014 14.8 0.1 0.058 12.8 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein AAA_22 PF13401.6 AET39513.1 - 0.13 12.6 0.0 0.75 10.1 0.0 2.4 2 1 0 2 2 2 0 AAA domain SPG4 PF17325.2 AET39513.1 - 2.2 9.4 5.2 1.5 10.0 1.6 2.6 2 0 0 2 2 2 0 Stationary phase protein 4 SmAKAP PF15127.6 AET39513.1 - 2.5 9.4 4.9 56 5.0 0.0 3.6 3 0 0 3 3 3 0 Small membrane A-kinase anchor protein Pre-PUA PF17832.1 AET39514.1 - 1.3e-25 89.9 1.6 2.1e-25 89.2 1.6 1.3 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 AET39514.1 - 1.1e-20 73.3 0.0 1.7e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 PUA domain DUF1947 PF09183.10 AET39514.1 - 0.00055 20.2 0.5 0.0015 18.8 0.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1947) DUF1133 PF06576.11 AET39514.1 - 0.14 11.5 0.1 0.2 11.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1133) LRR_4 PF12799.7 AET39515.1 - 7.4e-14 51.6 20.7 0.0038 17.6 1.1 6.4 4 1 2 6 6 6 5 Leucine Rich repeats (2 copies) CAP_GLY PF01302.25 AET39515.1 - 7e-11 42.0 0.0 1.1e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain LRR_8 PF13855.6 AET39515.1 - 2.7e-10 39.9 18.5 0.00056 19.6 2.6 5.8 3 2 3 6 6 6 3 Leucine rich repeat LRR_6 PF13516.6 AET39515.1 - 2.5e-09 36.4 13.2 0.59 10.3 0.2 7.8 8 0 0 8 8 8 3 Leucine Rich repeat LRR_9 PF14580.6 AET39515.1 - 3.2e-05 23.5 4.0 0.00015 21.3 1.1 3.0 1 1 2 3 3 3 1 Leucine-rich repeat LRR_1 PF00560.33 AET39515.1 - 0.0072 16.7 17.0 2.5 9.0 0.0 7.4 6 2 1 7 7 7 1 Leucine Rich Repeat DUF3340 PF11818.8 AET39515.1 - 0.02 15.1 0.0 0.036 14.2 0.0 1.4 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) Syntaxin-6_N PF09177.11 AET39515.1 - 0.13 12.8 0.0 25 5.5 0.0 2.6 2 0 0 2 2 2 0 Syntaxin 6, N-terminal AP4E_app_platf PF14807.6 AET39515.1 - 0.15 12.5 0.2 6.2 7.2 0.1 2.4 2 0 0 2 2 2 0 Adaptin AP4 complex epsilon appendage platform GN3L_Grn1 PF08701.11 AET39516.1 - 2e-23 82.3 13.2 5.7e-23 80.8 13.2 1.9 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 AET39516.1 - 2.5e-18 66.2 0.2 3.6e-14 52.8 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 AET39516.1 - 3.4e-09 36.4 0.1 1.6e-07 31.0 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AET39516.1 - 1.2e-05 25.3 0.2 0.00052 20.0 0.2 2.3 1 1 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 AET39516.1 - 4.1e-05 23.2 0.8 0.048 13.2 0.0 3.3 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 AET39516.1 - 5.1e-05 23.4 3.0 0.2 11.7 0.1 3.4 2 2 1 3 3 3 2 Dynamin family AIG1 PF04548.16 AET39516.1 - 0.0041 16.5 0.1 0.027 13.8 0.0 2.1 2 0 0 2 2 2 1 AIG1 family AAA_18 PF13238.6 AET39516.1 - 0.023 15.2 0.9 0.055 14.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 AET39516.1 - 0.026 14.1 0.2 1.7 8.2 0.0 2.6 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 AET39516.1 - 0.032 14.4 0.1 3.9 7.7 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 AET39516.1 - 0.035 13.1 0.1 0.082 11.9 0.1 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TFIIB PF00382.19 AET39517.1 - 2.8e-51 171.5 2.3 2e-26 91.8 0.6 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 AET39517.1 - 4.1e-13 48.6 0.8 7e-13 47.9 0.8 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding zf-ribbon_3 PF13248.6 AET39517.1 - 0.035 13.5 1.0 1.5 8.3 0.0 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Poxvirus PF06227.12 AET39517.1 - 0.081 12.7 0.2 0.12 12.2 0.2 1.4 1 0 0 1 1 1 0 dsDNA Poxvirus GDA1_CD39 PF01150.17 AET39518.1 - 5.3e-129 430.6 1.5 7.7e-129 430.0 1.5 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family HIM1 PF08732.10 AET39519.1 - 1.8e-11 43.8 0.0 2.5e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 HIM1 Epimerase PF01370.21 AET39519.1 - 2.7e-06 27.0 0.0 3.1e-05 23.6 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 AET39519.1 - 4.2e-05 23.5 0.0 6.9e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 AET39519.1 - 0.00015 21.4 0.0 0.00021 20.9 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family Semialdhyde_dh PF01118.24 AET39519.1 - 0.023 15.1 0.0 0.053 14.0 0.0 1.7 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Hexapep PF00132.24 AET39520.1 - 8.5e-06 25.3 11.6 0.00047 19.8 3.2 4.4 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 AET39520.1 - 0.013 15.2 12.9 0.14 11.9 4.8 3.7 3 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase DUF2190 PF09956.9 AET39520.1 - 0.051 14.1 0.0 0.075 13.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2190) PMI_typeI PF01238.21 AET39521.1 - 1.6e-146 488.3 0.0 1.8e-146 488.1 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.19 AET39521.1 - 0.014 15.3 0.0 8.2 6.3 0.0 2.7 3 0 0 3 3 3 0 AraC-like ligand binding domain FliG_N PF14842.6 AET39521.1 - 0.024 15.2 0.1 0.051 14.1 0.1 1.4 1 0 0 1 1 1 0 FliG N-terminal domain Nop16 PF09420.10 AET39522.1 - 2.5e-66 223.7 13.7 3.2e-66 223.4 13.7 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 BTHB PF18410.1 AET39522.1 - 0.018 14.8 0.3 0.06 13.2 0.3 1.9 1 0 0 1 1 1 0 Basic tilted helix bundle domain RRM_1 PF00076.22 AET39523.1 - 4e-17 61.8 0.1 8.2e-17 60.8 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AET39523.1 - 0.0042 16.9 0.0 0.0083 16.0 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 AET39523.1 - 0.067 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif BTB PF00651.31 AET39524.1 - 4.5e-22 78.4 0.8 5.1e-12 46.0 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain Ank_4 PF13637.6 AET39524.1 - 5.9e-08 33.1 0.2 1.7e-07 31.7 0.2 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 AET39524.1 - 1.5e-07 31.9 0.0 5.3e-07 30.1 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 AET39524.1 - 4.1e-05 23.8 0.4 0.034 14.6 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 AET39524.1 - 9.7e-05 22.6 0.1 0.00089 19.5 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 AET39524.1 - 0.00018 21.7 0.7 0.064 13.8 0.0 3.7 2 0 0 2 2 2 1 Ankyrin repeat G-alpha PF00503.20 AET39524.1 - 0.03 13.5 0.2 0.055 12.6 0.2 1.4 1 0 0 1 1 1 0 G-protein alpha subunit Syja_N PF02383.18 AET39525.1 - 2.4e-48 165.1 0.0 4.8e-48 164.1 0.0 1.5 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 AET39525.1 - 5.3e-12 45.8 0.0 7.9e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BLOC1_2 PF10046.9 AET39526.1 - 0.003 17.8 0.7 0.0034 17.7 0.7 1.1 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 T2SSF PF00482.23 AET39526.1 - 0.0062 16.5 0.4 0.0073 16.3 0.4 1.0 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein F UPF0184 PF03670.13 AET39526.1 - 0.015 15.7 0.9 0.017 15.5 0.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) UPF0449 PF15136.6 AET39526.1 - 0.077 13.5 0.5 0.095 13.2 0.4 1.3 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 DUF4349 PF14257.6 AET39526.1 - 0.08 12.4 1.3 0.092 12.2 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) DDOST_48kD PF03345.14 AET39527.1 - 2.7e-126 421.8 1.4 3.2e-126 421.5 1.4 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Prefoldin_2 PF01920.20 AET39528.1 - 1.9e-22 79.2 7.5 2.1e-22 79.1 7.5 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF2383 PF09537.10 AET39528.1 - 0.033 14.5 0.1 0.064 13.6 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF2383) VasL PF12486.8 AET39528.1 - 0.034 14.0 2.5 0.85 9.5 0.5 2.1 2 0 0 2 2 2 0 Type VI secretion system, EvfB, or VasL FlaC_arch PF05377.11 AET39528.1 - 0.086 13.2 6.5 0.098 13.1 0.5 2.4 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Prefoldin PF02996.17 AET39528.1 - 0.12 12.3 6.2 1.2 9.1 0.9 2.1 1 1 1 2 2 2 0 Prefoldin subunit FapA PF03961.13 AET39528.1 - 0.14 10.7 7.4 0.2 10.2 7.4 1.3 1 1 0 1 1 1 0 Flagellar Assembly Protein A Spc24 PF08286.11 AET39528.1 - 0.22 11.8 5.8 0.76 10.0 5.7 1.8 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 ApoLp-III PF07464.11 AET39529.1 - 0.015 15.4 4.4 1 9.4 0.2 2.4 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) NPV_P10 PF05531.12 AET39529.1 - 0.061 13.8 9.2 0.98 9.9 2.3 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 AET39529.1 - 0.21 11.6 4.3 0.81 9.7 4.2 1.9 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus LOH1CR12 PF10158.9 AET39529.1 - 0.24 11.4 4.9 0.65 10.0 4.9 1.7 1 1 1 2 2 2 0 Tumour suppressor protein Golgin_A5 PF09787.9 AET39529.1 - 0.24 10.8 8.3 0.38 10.2 8.3 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 Exonuc_VII_L PF02601.15 AET39529.1 - 0.4 10.2 4.1 0.53 9.8 4.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF724 PF05266.14 AET39529.1 - 0.51 10.1 4.9 0.84 9.4 4.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF1664 PF07889.12 AET39529.1 - 0.54 10.3 6.7 4.2 7.4 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TMPIT PF07851.13 AET39529.1 - 0.63 9.2 3.8 0.89 8.7 3.8 1.2 1 0 0 1 1 1 0 TMPIT-like protein CorA PF01544.18 AET39529.1 - 0.96 8.7 6.0 1.5 8.1 6.0 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF948 PF06103.11 AET39529.1 - 1.2 9.5 4.6 3 8.2 1.1 2.3 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Syntaxin_2 PF14523.6 AET39529.1 - 1.5 9.2 9.2 2.8 8.4 8.2 1.9 1 1 1 2 2 2 0 Syntaxin-like protein DUF16 PF01519.16 AET39529.1 - 2.6 8.6 8.3 1.2e+02 3.3 7.7 2.6 1 1 1 2 2 2 0 Protein of unknown function DUF16 Fib_alpha PF08702.10 AET39529.1 - 5.1 7.3 10.5 3.4 7.8 1.5 1.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family ParA PF10609.9 AET39530.1 - 4e-95 317.9 0.0 4.5e-95 317.8 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 AET39530.1 - 8.6e-10 38.8 0.0 4e-09 36.6 0.0 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 AET39530.1 - 1.8e-06 28.0 1.2 1.7e-05 24.8 1.2 2.1 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 AET39530.1 - 3.5e-06 26.5 0.0 2.1e-05 24.0 0.0 2.0 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 AET39530.1 - 2.6e-05 23.6 1.4 0.00018 20.8 0.4 2.2 2 1 0 2 2 2 1 Anion-transporting ATPase MeaB PF03308.16 AET39530.1 - 0.0014 17.7 0.3 0.0021 17.1 0.3 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Fer4_NifH PF00142.18 AET39530.1 - 0.013 15.0 0.1 0.099 12.1 0.1 2.0 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.12 AET39530.1 - 0.027 13.9 0.0 0.051 13.0 0.0 1.4 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ AAA_25 PF13481.6 AET39530.1 - 0.058 13.0 0.6 0.095 12.3 0.6 1.2 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 AET39530.1 - 0.12 12.3 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_26 PF13500.6 AET39530.1 - 0.21 11.4 1.1 1.9 8.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain Use1 PF09753.9 AET39531.1 - 4.7e-05 23.2 0.1 6.6e-05 22.7 0.1 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 Synaptobrevin PF00957.21 AET39531.1 - 0.016 15.0 2.0 0.031 14.0 2.0 1.6 1 1 0 1 1 1 0 Synaptobrevin Thioredoxin PF00085.20 AET39532.1 - 3.1e-17 62.5 0.6 4.6e-15 55.5 0.0 3.0 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 AET39532.1 - 5.2e-06 26.5 7.4 0.00058 19.8 1.4 4.5 3 2 1 4 4 4 2 Thioredoxin-like domain Mito_carr PF00153.27 AET39533.1 - 4.9e-67 221.9 4.9 2.3e-24 85.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Gti1_Pac2 PF09729.9 AET39535.1 - 1.5e-54 184.9 17.9 2.7e-54 184.0 0.0 2.9 2 2 0 2 2 2 1 Gti1/Pac2 family Presenilin PF01080.17 AET39535.1 - 2.5 6.8 14.6 3.6 6.2 14.6 1.2 1 0 0 1 1 1 0 Presenilin ASD2 PF08687.11 AET39535.1 - 2.5 7.6 12.4 4.5 6.7 12.4 1.5 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Hid1 PF12722.7 AET39535.1 - 3.6 5.6 12.8 4.5 5.3 12.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Macoilin PF09726.9 AET39535.1 - 8.4 4.8 13.4 13 4.2 13.4 1.2 1 0 0 1 1 1 0 Macoilin family bZIP_2 PF07716.15 AET39536.1 - 6.7e-12 45.3 9.7 1.2e-11 44.5 9.7 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 AET39536.1 - 3.9e-10 39.7 10.1 8.1e-10 38.7 10.1 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 AET39536.1 - 0.01 16.4 4.3 0.02 15.4 4.3 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor Nas2_N PF18265.1 AET39537.1 - 2.5e-21 75.4 0.3 4.5e-21 74.5 0.3 1.4 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ PF00595.24 AET39537.1 - 1.2e-05 25.5 0.1 1.8e-05 25.0 0.1 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 AET39537.1 - 7.9e-05 22.4 0.0 0.00014 21.7 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 AET39537.1 - 0.00068 19.9 0.0 0.0011 19.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 AET39537.1 - 0.0015 18.8 0.0 0.0023 18.3 0.0 1.2 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain Urm1 PF09138.11 AET39538.1 - 8.2e-36 122.3 0.5 9.2e-36 122.1 0.5 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 AET39538.1 - 0.0095 16.6 0.0 0.012 16.3 0.0 1.2 1 0 0 1 1 1 1 ThiS family SWIB PF02201.18 AET39538.1 - 0.14 12.1 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 SWIB/MDM2 domain ATP-synt PF00231.19 AET39539.1 - 1.8e-77 260.8 7.0 2e-77 260.6 7.0 1.0 1 0 0 1 1 1 1 ATP synthase Fig1 PF12351.8 AET39540.1 - 1.6e-52 178.2 1.3 1.6e-52 178.2 1.3 1.7 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SH3_6 PF12913.7 AET39540.1 - 0.027 14.0 0.0 0.045 13.3 0.0 1.4 1 0 0 1 1 1 0 SH3 domain (SH3b1 type) TssO PF17561.2 AET39540.1 - 0.24 11.5 0.0 0.24 11.5 0.0 2.8 3 0 0 3 3 3 0 Type VI secretion system, TssO CCSMST1 PF15013.6 AET39540.1 - 0.47 10.7 2.2 0.95 9.7 0.2 2.5 2 0 0 2 2 2 0 CCSMST1 family DUF1189 PF06691.11 AET39540.1 - 2.7 7.5 14.2 0.43 10.1 9.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1189) SUR7 PF06687.12 AET39540.1 - 3.6 7.2 18.0 23 4.5 18.0 2.2 1 1 0 1 1 1 0 SUR7/PalI family AMP-binding PF00501.28 AET39541.1 - 2.5e-53 181.2 0.0 3.1e-53 180.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AET39541.1 - 0.0044 18.0 0.0 0.0084 17.1 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Acyltransferase PF01553.21 AET39542.1 - 1.1e-28 99.5 0.0 1.9e-28 98.8 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 AET39542.1 - 1.9e-13 50.3 0.0 4.5e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase C-terminus MFS_1 PF07690.16 AET39543.1 - 7.6e-39 133.6 29.5 1e-38 133.2 24.8 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 AET39543.1 - 1.7e-05 24.3 0.6 1.7e-05 24.3 0.6 2.1 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB VIT1 PF01988.19 AET39543.1 - 0.057 13.3 0.1 0.057 13.3 0.1 2.2 2 0 0 2 2 2 0 VIT family Pex14_N PF04695.13 AET39544.1 - 0.084 13.5 0.0 0.099 13.3 0.0 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3258 PF11646.8 AET39544.1 - 0.1 12.8 0.2 0.25 11.5 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF3258 SpoOE-like PF09388.10 AET39544.1 - 0.13 12.2 0.3 0.23 11.4 0.3 1.5 1 0 0 1 1 1 0 Spo0E like sporulation regulatory protein DUF3446 PF11928.8 AET39545.1 - 0.0021 18.3 0.1 0.0025 18.1 0.1 1.1 1 0 0 1 1 1 1 Early growth response N-terminal domain YCII PF03795.14 AET39546.1 - 7.5e-07 29.5 0.0 9.7e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain Profilin PF00235.19 AET39547.1 - 3.6e-44 150.1 0.3 4e-44 149.9 0.3 1.0 1 0 0 1 1 1 1 Profilin Leo1 PF04004.13 AET39548.1 - 2e-47 161.1 1.0 4.4e-47 160.0 0.0 2.1 2 0 0 2 2 2 1 Leo1-like protein Kinase-PolyVal PF18762.1 AET39548.1 - 0.019 14.9 0.2 0.036 14.0 0.2 1.4 1 0 0 1 1 1 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins Glyco_hydro_18 PF00704.28 AET39549.1 - 1.6e-70 238.3 2.2 1.9e-70 238.1 2.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 GPP34 PF05719.11 AET39550.1 - 2.9e-64 216.8 0.0 3.6e-64 216.6 0.0 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) UCH PF00443.29 AET39551.1 - 2.1e-56 191.3 0.0 7.2e-55 186.3 0.0 2.7 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 AET39551.1 - 2.4e-43 145.8 8.6 1.3e-16 60.2 0.1 4.8 4 0 0 4 4 4 4 A repeated domain in UCH-protein UCH_1 PF13423.6 AET39551.1 - 0.00021 21.0 8.7 0.026 14.1 1.0 3.0 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase PUB PF09409.10 AET39551.1 - 0.018 14.9 0.0 0.053 13.5 0.0 1.7 1 0 0 1 1 1 0 PUB domain DnaJ PF00226.31 AET39551.1 - 0.025 14.7 0.8 7.4 6.8 0.0 3.5 3 0 0 3 3 3 0 DnaJ domain EF-hand_1 PF00036.32 AET39552.1 - 1.3e-28 96.3 5.9 9.3e-08 31.1 0.3 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 AET39552.1 - 2.3e-26 92.0 5.9 1.6e-17 63.7 0.3 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 AET39552.1 - 2.8e-25 86.0 5.6 9e-07 28.3 0.1 4.9 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 AET39552.1 - 4.5e-18 64.8 7.1 1.5e-09 37.5 0.1 4.1 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 AET39552.1 - 7.7e-18 63.1 9.7 2.8e-05 23.4 0.2 5.1 5 1 0 5 5 5 3 EF hand SPARC_Ca_bdg PF10591.9 AET39552.1 - 9e-06 26.0 1.3 0.25 11.7 0.1 3.0 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 AET39552.1 - 4.3e-05 23.4 5.5 0.53 10.3 0.1 3.7 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 AET39552.1 - 0.00058 20.1 0.3 0.074 13.4 0.1 2.8 1 1 1 2 2 2 1 EF-hand domain S10_plectin PF03501.15 AET39552.1 - 0.096 12.8 0.0 0.21 11.7 0.0 1.7 1 1 0 1 1 1 0 Plectin/S10 domain DUF5552 PF17706.1 AET39552.1 - 0.097 12.4 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5552) COQ7 PF03232.13 AET39553.1 - 2.8e-73 245.3 0.0 3.3e-73 245.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 AET39553.1 - 0.063 13.7 0.0 0.15 12.5 0.0 1.7 2 0 0 2 2 2 0 Rubrerythrin YTH PF04146.15 AET39554.1 - 9.2e-31 107.0 1.1 2.5e-30 105.6 1.1 1.7 1 1 0 1 1 1 1 YT521-B-like domain RE_AspBHI_N PF18062.1 AET39554.1 - 0.00044 19.9 0.1 0.00075 19.1 0.1 1.3 1 0 0 1 1 1 1 Restriction endonuclease AspBHI N-terminal Sel1 PF08238.12 AET39555.1 - 1.6e-14 54.0 13.0 8.2e-05 23.1 0.3 6.1 7 0 0 7 7 7 4 Sel1 repeat TPR_2 PF07719.17 AET39555.1 - 0.001 19.0 9.5 0.26 11.5 0.4 5.7 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 AET39555.1 - 0.0051 16.6 6.4 2.1 8.3 0.4 4.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 AET39555.1 - 0.0057 16.6 2.2 0.19 11.9 0.1 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AET39555.1 - 0.0072 16.5 0.1 0.0072 16.5 0.1 2.4 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 AET39555.1 - 0.0078 16.3 6.5 8.9 6.8 0.2 5.6 4 1 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 AET39555.1 - 0.023 15.3 6.6 13 6.7 0.0 5.0 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 AET39555.1 - 0.055 14.0 0.3 0.055 14.0 0.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 AET39555.1 - 0.48 10.7 3.5 11 6.4 0.9 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 AET39555.1 - 0.53 11.0 8.7 0.64 10.7 0.4 3.7 2 1 0 3 3 3 0 Tetratricopeptide repeat Dynactin_p62 PF05502.13 AET39556.1 - 1.8e-13 50.1 24.7 1.1e-06 27.7 0.2 2.1 1 1 0 2 2 2 2 Dynactin p62 family MANEC PF07502.14 AET39556.1 - 0.00068 19.9 9.0 0.00068 19.9 9.0 2.0 1 1 1 2 2 2 1 MANEC domain zf_UBZ PF18439.1 AET39556.1 - 0.44 10.2 9.9 0.7 9.5 0.1 3.3 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-Mss51 PF13824.6 AET39556.1 - 0.57 10.3 11.5 0.83 9.8 6.7 2.7 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 Elf1 PF05129.13 AET39556.1 - 1.9 8.6 17.0 0.67 10.0 3.5 3.0 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like CENP-X PF09415.10 AET39557.1 - 1.9e-24 85.8 0.1 2.1e-24 85.6 0.1 1.0 1 0 0 1 1 1 1 CENP-S associating Centromere protein X MMR_HSR1_Xtn PF16897.5 AET39558.1 - 1.4e-35 121.5 0.9 2.6e-35 120.6 0.9 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 AET39558.1 - 4e-23 81.7 0.1 1e-22 80.4 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 AET39558.1 - 4.9e-20 71.3 0.0 1.1e-19 70.2 0.0 1.7 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 AET39558.1 - 1.6e-15 57.0 0.0 2.9e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 AET39558.1 - 2e-05 24.7 0.7 0.0031 17.6 0.0 2.4 1 1 1 2 2 2 1 Dynamin family AIG1 PF04548.16 AET39558.1 - 0.0013 18.1 0.1 0.0023 17.3 0.1 1.4 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.10 AET39558.1 - 0.0023 17.4 0.7 0.01 15.3 0.1 2.1 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 AET39558.1 - 0.0054 16.9 0.3 0.11 12.7 0.0 2.7 2 1 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 AET39558.1 - 0.0086 15.2 0.0 0.025 13.7 0.0 1.7 1 0 0 1 1 1 1 MCM P-loop domain Ras PF00071.22 AET39558.1 - 0.025 14.2 0.3 0.62 9.7 0.0 2.3 2 0 0 2 2 2 0 Ras family GTP_EFTU PF00009.27 AET39558.1 - 0.039 13.5 0.8 1.5 8.4 0.2 2.9 2 1 1 3 3 3 0 Elongation factor Tu GTP binding domain YchF-GTPase_C PF06071.13 AET39558.1 - 0.057 13.6 0.1 0.33 11.2 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF933) AAA_16 PF13191.6 AET39558.1 - 0.067 13.6 0.2 0.17 12.3 0.2 1.8 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 AET39558.1 - 0.18 11.7 1.0 1.5 8.7 0.1 2.7 3 0 0 3 3 3 0 RsgA GTPase Yip1 PF04893.17 AET39559.1 - 1.5e-07 31.3 17.7 4.2e-05 23.3 12.0 2.2 2 0 0 2 2 2 2 Yip1 domain DUF5325 PF17259.2 AET39559.1 - 0.0092 15.8 0.7 0.0092 15.8 0.7 1.9 2 0 0 2 2 2 1 Family of unknown function (DUF5325) DUF5090 PF17009.5 AET39559.1 - 0.034 14.1 3.4 0.076 13.0 3.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) Pkinase PF00069.25 AET39560.1 - 2e-65 220.8 0.0 3e-65 220.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET39560.1 - 4.1e-29 101.6 0.0 9.2e-29 100.5 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET39560.1 - 7.3e-09 35.4 0.0 8.2e-08 31.9 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 AET39560.1 - 0.00047 20.2 0.1 0.0053 16.7 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 AET39560.1 - 0.0056 16.1 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 AET39560.1 - 0.016 14.2 0.0 0.035 13.1 0.0 1.5 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 AET39560.1 - 0.055 13.1 0.0 2.6 7.6 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DAO PF01266.24 AET39561.1 - 1.3e-82 278.2 0.0 1.6e-82 278.0 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 AET39561.1 - 6.6e-07 29.5 0.1 1.7e-06 28.1 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 AET39561.1 - 0.00011 21.5 0.1 0.00019 20.8 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 AET39561.1 - 0.0013 18.1 0.0 0.094 11.9 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 AET39561.1 - 0.0035 17.6 0.1 0.0071 16.6 0.1 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_9 PF13454.6 AET39561.1 - 0.013 15.5 0.1 0.032 14.2 0.1 1.7 1 0 0 1 1 1 0 FAD-NAD(P)-binding MCRA PF06100.11 AET39561.1 - 0.014 14.3 0.1 0.021 13.7 0.1 1.2 1 0 0 1 1 1 0 MCRA family Trp_halogenase PF04820.14 AET39561.1 - 0.08 11.8 0.1 0.13 11.1 0.1 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox PF00070.27 AET39561.1 - 0.14 12.8 0.1 0.33 11.5 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AET39561.1 - 0.14 11.2 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Syntaxin-6_N PF09177.11 AET39562.1 - 1.3e-05 25.7 11.6 0.0006 20.3 7.5 3.1 2 1 0 2 2 2 1 Syntaxin 6, N-terminal Use1 PF09753.9 AET39562.1 - 0.0016 18.2 9.2 0.0035 17.1 9.2 1.5 1 1 0 1 1 1 1 Membrane fusion protein Use1 IL2 PF00715.17 AET39562.1 - 0.0018 18.2 4.1 0.21 11.5 1.9 2.3 1 1 1 2 2 2 1 Interleukin 2 TFA2_Winged_2 PF18121.1 AET39562.1 - 0.0038 16.9 0.8 0.0081 15.8 0.8 1.5 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 BLUF PF04940.12 AET39562.1 - 0.0091 16.1 2.6 2.6 8.2 0.2 2.6 2 1 0 2 2 2 1 Sensors of blue-light using FAD MPS2 PF17060.5 AET39562.1 - 0.015 14.6 0.1 0.015 14.6 0.1 2.0 1 1 1 2 2 2 0 Monopolar spindle protein 2 SNARE PF05739.19 AET39562.1 - 0.037 14.0 0.3 0.037 14.0 0.3 3.1 5 0 0 5 5 2 0 SNARE domain SKA1 PF07160.12 AET39562.1 - 0.041 13.7 8.1 0.28 11.0 0.2 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Noelin-1 PF12308.8 AET39562.1 - 0.053 13.5 10.4 0.9 9.6 1.7 2.8 2 1 1 3 3 3 0 Neurogenesis glycoprotein ABC2_membrane_3 PF12698.7 AET39562.1 - 0.066 12.3 0.3 0.085 12.0 0.3 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Sec20 PF03908.13 AET39562.1 - 0.068 13.1 0.2 0.068 13.1 0.2 2.8 2 1 1 3 3 3 0 Sec20 DUF4635 PF15466.6 AET39562.1 - 0.081 12.4 3.4 2.2 7.8 1.8 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4635) Troponin PF00992.20 AET39562.1 - 0.088 13.1 8.0 0.057 13.7 5.5 1.9 1 1 1 2 2 2 0 Troponin Reprolysin PF01421.19 AET39562.1 - 0.089 12.7 1.3 0.12 12.2 1.3 1.2 1 0 0 1 1 1 0 Reprolysin (M12B) family zinc metalloprotease DUF1664 PF07889.12 AET39562.1 - 0.13 12.4 10.8 1.4 9.0 0.5 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) TMPIT PF07851.13 AET39562.1 - 0.13 11.5 4.8 0.22 10.7 3.4 1.9 1 1 0 1 1 1 0 TMPIT-like protein DUF4201 PF13870.6 AET39562.1 - 0.16 11.7 13.3 0.82 9.4 6.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Nup88 PF10168.9 AET39562.1 - 0.2 9.4 12.1 0.21 9.4 0.2 2.0 1 1 1 2 2 2 0 Nuclear pore component Laminin_II PF06009.12 AET39562.1 - 0.27 11.3 10.4 2.6 8.0 0.1 2.2 2 0 0 2 2 2 0 Laminin Domain II DUF948 PF06103.11 AET39562.1 - 0.3 11.4 5.2 14 6.0 1.2 3.1 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) HrpB7 PF09486.10 AET39562.1 - 0.51 10.7 8.3 1.4 9.2 2.5 2.2 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Atg14 PF10186.9 AET39562.1 - 0.52 9.3 10.3 0.77 8.8 10.3 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 LMBR1 PF04791.16 AET39562.1 - 0.53 9.1 7.3 0.78 8.6 7.3 1.3 1 1 0 1 1 1 0 LMBR1-like membrane protein Occludin_ELL PF07303.13 AET39562.1 - 0.9 10.3 8.5 5.7 7.7 3.2 3.3 2 1 0 2 2 2 0 Occludin homology domain RIG-I_C PF18119.1 AET39562.1 - 0.91 9.5 6.1 3.7 7.6 0.1 2.7 2 1 0 2 2 2 0 RIG-I receptor C-terminal domain KxDL PF10241.9 AET39562.1 - 0.93 9.8 6.5 1.6 9.0 0.3 2.7 2 1 1 3 3 3 0 Uncharacterized conserved protein ZapD PF07072.11 AET39562.1 - 0.94 9.2 8.8 4 7.1 1.2 2.6 1 1 0 2 2 2 0 Cell division protein FlaC_arch PF05377.11 AET39562.1 - 1.1 9.7 12.3 29 5.1 2.9 4.1 2 2 1 4 4 4 0 Flagella accessory protein C (FlaC) BST2 PF16716.5 AET39562.1 - 1.1 9.9 12.1 0.33 11.6 0.3 2.8 2 1 0 2 2 2 0 Bone marrow stromal antigen 2 YabA PF06156.13 AET39562.1 - 1.1 9.9 13.1 4.4 8.0 0.5 2.9 2 1 0 2 2 2 0 Initiation control protein YabA Baculo_PEP_C PF04513.12 AET39562.1 - 1.3 9.1 10.4 2e+02 2.0 10.5 2.4 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 AET39562.1 - 1.3 7.9 16.4 4 6.2 10.9 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein MCU PF04678.13 AET39562.1 - 1.3 9.1 7.3 11 6.0 3.3 2.1 1 1 1 2 2 2 0 Mitochondrial calcium uniporter Phage_GPO PF05929.11 AET39562.1 - 1.3 8.5 9.5 0.92 9.1 3.6 2.0 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase APG6_N PF17675.1 AET39562.1 - 1.5 9.4 13.6 2.8 8.5 8.3 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF745 PF05335.13 AET39562.1 - 1.6 8.5 10.9 3 7.5 1.4 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF745) DASH_Dad1 PF08649.10 AET39562.1 - 1.7 8.9 5.6 12 6.2 0.1 3.6 2 2 2 4 4 4 0 DASH complex subunit Dad1 Golgin_A5 PF09787.9 AET39562.1 - 2 7.8 19.1 0.35 10.3 10.7 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 5 Tweety PF04906.13 AET39562.1 - 2 7.0 7.4 0.34 9.5 0.3 2.4 2 1 0 2 2 2 0 Tweety AAA_13 PF13166.6 AET39562.1 - 2.1 6.9 11.0 5.6 5.5 6.8 1.9 1 1 1 2 2 2 0 AAA domain ING PF12998.7 AET39562.1 - 2.2 8.9 11.4 0.76 10.4 5.9 2.2 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Exonuc_VII_L PF02601.15 AET39562.1 - 3.6 7.1 12.8 21 4.5 12.8 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF4200 PF13863.6 AET39562.1 - 3.7 8.0 12.2 1.9 8.9 6.5 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) WXG100 PF06013.12 AET39562.1 - 4.2 7.7 9.3 6.1 7.2 1.0 3.4 2 2 1 3 3 3 0 Proteins of 100 residues with WXG Baculo_p24 PF05073.12 AET39562.1 - 5.9 6.6 8.9 6.1 6.6 2.7 2.1 1 1 1 2 2 2 0 Baculovirus P24 capsid protein Cluap1 PF10234.9 AET39562.1 - 6.8 6.0 12.1 10 5.4 0.5 2.1 1 1 1 2 2 2 0 Clusterin-associated protein-1 Dpy-30 PF05186.13 AET39563.1 - 2.4e-14 52.8 0.0 3.1e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Dpy-30 motif Mito_carr PF00153.27 AET39564.1 - 5.8e-13 48.6 0.0 0.00033 20.5 0.0 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein Laminin_II PF06009.12 AET39565.1 - 0.031 14.3 13.2 0.59 10.1 0.5 2.6 2 1 0 2 2 2 0 Laminin Domain II DUF3734 PF12536.8 AET39565.1 - 0.11 12.8 1.1 0.26 11.6 0.8 1.7 1 1 0 1 1 1 0 Patatin phospholipase PCRF PF03462.18 AET39565.1 - 0.26 11.1 13.4 0.78 9.6 0.7 2.4 1 1 2 3 3 3 0 PCRF domain Mod_r PF07200.13 AET39565.1 - 0.45 10.6 21.2 2.5 8.2 8.9 2.9 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DUF4407 PF14362.6 AET39565.1 - 0.8 9.0 6.6 1.3 8.4 6.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Atg14 PF10186.9 AET39565.1 - 1.3 8.1 13.5 0.64 9.1 11.2 1.6 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Phage_GP20 PF06810.11 AET39565.1 - 2.5 7.9 16.7 0.1 12.4 4.8 2.6 1 1 1 2 2 2 0 Phage minor structural protein GP20 Fib_alpha PF08702.10 AET39565.1 - 5.8 7.1 11.6 26 5.0 0.4 3.1 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family KxDL PF10241.9 AET39565.1 - 6 7.2 13.0 0.34 11.2 3.6 2.9 1 1 2 3 3 3 0 Uncharacterized conserved protein Seryl_tRNA_N PF02403.22 AET39565.1 - 6.5 7.0 16.8 4 7.7 5.3 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain NPV_P10 PF05531.12 AET39565.1 - 7.7 7.1 11.6 9.6 6.8 3.3 4.0 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Ribosomal_L27e PF01777.18 AET39566.1 - 3.9e-36 123.3 7.2 6.2e-36 122.6 7.2 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 AET39566.1 - 0.005 16.8 1.1 0.009 15.9 1.1 1.5 1 0 0 1 1 1 1 KOW motif tRNA-synt_2b PF00587.25 AET39567.1 - 3.2e-22 79.4 0.0 7.1e-22 78.2 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 AET39567.1 - 7e-05 23.0 8.7 0.00013 22.2 8.7 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain GAS PF13851.6 AET39567.1 - 0.011 15.2 8.7 0.02 14.2 8.7 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Lebercilin PF15619.6 AET39567.1 - 0.027 14.2 7.9 0.048 13.3 7.9 1.3 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF3014 PF11219.8 AET39567.1 - 0.033 14.5 0.1 0.33 11.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3014) PhaP_Bmeg PF09602.10 AET39567.1 - 0.061 13.3 3.4 0.1 12.5 3.4 1.3 1 0 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) FapA PF03961.13 AET39567.1 - 0.068 11.8 3.3 0.19 10.3 3.7 1.5 2 0 0 2 2 2 0 Flagellar Assembly Protein A DUF3450 PF11932.8 AET39567.1 - 0.07 12.4 5.5 0.11 11.8 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) tRNA-synt_His PF13393.6 AET39567.1 - 0.089 12.0 3.2 5.4 6.2 0.0 2.1 2 0 0 2 2 2 0 Histidyl-tRNA synthetase Tho2 PF11262.8 AET39567.1 - 0.22 10.7 5.0 0.33 10.1 5.0 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 rRNA_proc-arch PF13234.6 AET39567.1 - 0.23 11.4 6.2 0.46 10.4 6.2 1.5 1 0 0 1 1 1 0 rRNA-processing arch domain Sec2p PF06428.11 AET39567.1 - 0.23 11.4 6.7 0.49 10.4 6.7 1.6 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p APG6_N PF17675.1 AET39567.1 - 0.27 11.8 9.4 0.62 10.6 9.4 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region V_ATPase_I PF01496.19 AET39567.1 - 0.32 8.9 2.0 0.41 8.5 2.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fib_alpha PF08702.10 AET39567.1 - 0.48 10.6 7.6 0.88 9.8 7.6 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family AAA_23 PF13476.6 AET39567.1 - 0.81 10.2 7.6 1.5 9.3 7.6 1.3 1 0 0 1 1 1 0 AAA domain Med9 PF07544.13 AET39567.1 - 2.7 8.1 10.5 5.5 7.1 10.5 1.4 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Metallophos_2 PF12850.7 AET39568.1 - 4.1e-07 30.3 0.0 5.8e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain CENP-B_dimeris PF09026.10 AET39568.1 - 0.034 14.5 0.4 0.059 13.8 0.4 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Acetyltransf_1 PF00583.25 AET39569.1 - 3.7e-13 49.7 0.0 6.3e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AET39569.1 - 4.4e-06 26.7 0.1 6.1e-06 26.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AET39569.1 - 7.8e-06 26.2 0.0 1.3e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AET39569.1 - 2.3e-05 24.3 0.0 4.2e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_15 PF17013.5 AET39569.1 - 0.0035 16.8 0.2 0.0046 16.5 0.2 1.3 1 1 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_9 PF13527.7 AET39569.1 - 0.0065 16.5 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 AET39569.1 - 0.068 13.3 0.0 0.3 11.2 0.0 2.1 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase TRAPP PF04051.16 AET39570.1 - 9.1e-44 148.7 0.0 1.1e-43 148.4 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Ribosomal_L23 PF00276.20 AET39573.1 - 4.4e-13 49.4 0.0 1.3e-12 47.8 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L23 RNA_pol_Rpb2_6 PF00562.28 AET39574.1 - 1.3e-124 416.3 0.1 1.9e-124 415.7 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 AET39574.1 - 3.2e-69 232.5 0.1 5.6e-69 231.7 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 AET39574.1 - 1.8e-51 174.5 0.0 3.2e-51 173.7 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 AET39574.1 - 3.8e-34 116.9 0.1 8.6e-34 115.8 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 AET39574.1 - 2.3e-25 88.6 0.8 6.2e-25 87.3 0.8 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 AET39574.1 - 3.2e-24 84.9 1.0 6.4e-24 83.9 0.1 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 AET39574.1 - 1.6e-19 70.2 1.0 1.6e-19 70.2 1.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 MRNIP PF15749.5 AET39574.1 - 0.087 13.6 0.1 0.17 12.6 0.1 1.5 1 0 0 1 1 1 0 MRN-interacting protein RNA_pol_Rpb2_45 PF10385.9 AET39574.1 - 0.16 12.2 0.6 1.7 9.0 0.1 2.5 2 0 0 2 2 2 0 RNA polymerase beta subunit external 1 domain Ribosomal_L13 PF00572.18 AET39575.1 - 7.5e-47 158.7 0.3 9.3e-47 158.4 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L13 SHS2_Rpb7-N PF03876.17 AET39576.1 - 1.4e-18 67.0 0.0 2.4e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 AET39576.1 - 3.9e-13 49.6 0.0 5.8e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.12 AET39576.1 - 0.001 19.3 0.0 0.002 18.3 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 DIT1_PvcA PF05141.12 AET39577.1 - 1.4e-99 333.1 0.0 1.9e-99 332.6 0.0 1.2 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein Spt4 PF06093.13 AET39577.1 - 0.15 12.2 0.1 0.61 10.2 0.0 2.1 2 0 0 2 2 2 0 Spt4/RpoE2 zinc finger DUF5348 PF17295.2 AET39577.1 - 0.17 11.8 4.6 0.33 10.9 0.7 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF5348) IU_nuc_hydro PF01156.19 AET39578.1 - 4.3e-66 223.6 0.0 5e-66 223.3 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Utp12 PF04003.12 AET39579.1 - 1.1e-18 67.5 2.6 2e-18 66.6 2.6 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 AET39579.1 - 0.00076 19.7 0.0 0.027 14.8 0.0 3.1 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain CBFD_NFYB_HMF PF00808.23 AET39580.1 - 4.7e-14 52.4 1.5 8.2e-14 51.6 1.5 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Lig_C PF18330.1 AET39580.1 - 0.029 14.4 1.1 0.037 14.0 1.1 1.3 1 0 0 1 1 1 0 Ligase Pab1020 C-terminal region DUF2795 PF11387.8 AET39580.1 - 0.11 12.7 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2795) Hydrolase_like PF13242.6 AET39580.1 - 0.14 12.2 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like Histone PF00125.24 AET39580.1 - 0.18 12.2 0.2 0.18 12.2 0.2 2.0 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 IBN_N PF03810.19 AET39581.1 - 2.4e-11 43.4 3.6 2.6e-11 43.3 0.6 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain DUF445 PF04286.12 AET39581.1 - 0.018 14.9 0.8 0.24 11.2 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF445) Telomerase_RBD PF12009.8 AET39581.1 - 0.034 14.2 0.3 0.13 12.4 0.1 2.1 2 0 0 2 2 2 0 Telomerase ribonucleoprotein complex - RNA binding domain RIX1 PF08167.12 AET39581.1 - 0.11 12.3 0.2 0.62 9.8 0.1 2.3 1 1 1 2 2 2 0 rRNA processing/ribosome biogenesis Vac14_Fab1_bd PF12755.7 AET39581.1 - 0.2 12.2 1.3 0.98 10.1 0.2 2.9 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region P_C10 PF14974.6 AET39581.1 - 0.2 11.7 1.2 1.2 9.3 0.1 3.0 2 0 0 2 2 2 0 Protein C10 Glyco_transf_22 PF03901.17 AET39582.1 - 2.7e-59 201.5 19.9 2.7e-59 201.5 19.9 1.3 2 0 0 2 2 2 1 Alg9-like mannosyltransferase family AAA PF00004.29 AET39583.1 - 3.5e-46 156.9 0.0 1e-45 155.4 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 AET39583.1 - 3e-09 36.7 0.2 1.4e-08 34.5 0.0 2.3 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 AET39583.1 - 2.9e-08 34.0 0.0 5.5e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 AET39583.1 - 1.5e-07 32.0 0.0 2.7e-05 24.6 0.0 3.1 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 AET39583.1 - 2.9e-07 30.6 0.1 1.1e-06 28.6 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AET39583.1 - 2.6e-05 24.5 0.7 0.0039 17.5 0.0 2.6 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 AET39583.1 - 6.9e-05 22.1 0.0 0.00012 21.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 AET39583.1 - 0.00023 21.0 0.0 0.00074 19.3 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 AET39583.1 - 0.00069 19.6 0.1 0.0028 17.6 0.0 2.0 3 0 0 3 3 2 1 NTPase TIP49 PF06068.13 AET39583.1 - 0.0014 17.9 0.0 0.0024 17.1 0.0 1.4 1 1 0 1 1 1 1 TIP49 P-loop domain TsaE PF02367.17 AET39583.1 - 0.0015 18.5 0.0 0.0028 17.7 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 AET39583.1 - 0.0015 18.3 0.0 0.004 16.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_lid_3 PF17862.1 AET39583.1 - 0.0015 18.3 0.1 0.0033 17.2 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_18 PF13238.6 AET39583.1 - 0.0017 18.9 0.0 0.0079 16.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 AET39583.1 - 0.002 18.5 0.0 0.0039 17.6 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_7 PF12775.7 AET39583.1 - 0.0027 17.2 0.0 0.022 14.3 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_14 PF13173.6 AET39583.1 - 0.0033 17.4 0.0 0.0076 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 AET39583.1 - 0.0034 17.1 0.0 0.0057 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 AET39583.1 - 0.0039 17.0 0.0 0.011 15.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 AET39583.1 - 0.0052 16.2 0.0 0.3 10.5 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein AAA_33 PF13671.6 AET39583.1 - 0.0062 16.7 0.0 0.014 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 AET39583.1 - 0.0065 16.2 0.1 0.17 11.6 0.0 2.5 2 1 0 2 2 2 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 AET39583.1 - 0.0074 15.7 0.1 0.018 14.4 0.0 1.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 AET39583.1 - 0.013 15.8 0.0 0.034 14.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 AET39583.1 - 0.016 15.2 0.1 0.12 12.3 0.0 2.2 1 1 1 2 2 2 0 NACHT domain IstB_IS21 PF01695.17 AET39583.1 - 0.025 14.3 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase_2 PF01637.18 AET39583.1 - 0.03 14.3 0.1 0.41 10.5 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 AET39583.1 - 0.036 13.9 0.0 0.079 12.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 AET39583.1 - 0.082 12.5 0.4 0.48 10.0 0.1 2.1 1 1 0 2 2 2 0 AAA domain AFG1_ATPase PF03969.16 AET39583.1 - 0.092 11.6 0.0 0.15 10.9 0.0 1.4 1 0 0 1 1 1 0 AFG1-like ATPase AAA_19 PF13245.6 AET39583.1 - 0.13 12.6 0.1 0.35 11.2 0.0 1.7 2 0 0 2 2 1 0 AAA domain She9_MDM33 PF05546.11 AET39584.1 - 4.9e-83 277.8 13.4 4.9e-83 277.8 13.4 2.1 2 0 0 2 2 2 1 She9 / Mdm33 family HU-CCDC81_bac_2 PF18175.1 AET39584.1 - 0.055 13.4 0.2 0.27 11.1 0.2 2.3 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 zf-RING_9 PF13901.6 AET39584.1 - 0.28 11.1 4.8 0.095 12.7 1.4 1.9 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon DASH_Dad4 PF08650.10 AET39584.1 - 0.38 10.7 9.6 0.63 10.0 0.1 3.5 3 0 0 3 3 3 0 DASH complex subunit Dad4 SKA1 PF07160.12 AET39584.1 - 0.77 9.6 24.6 0.31 10.9 7.5 3.0 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 1 G-patch_2 PF12656.7 AET39585.1 - 4.7e-19 68.2 0.5 4.7e-19 68.2 0.5 2.0 3 0 0 3 3 3 1 G-patch domain MDM31_MDM32 PF08118.11 AET39586.1 - 4.6e-95 319.3 14.0 5.6e-43 147.4 0.7 4.0 2 1 2 4 4 4 4 Yeast mitochondrial distribution and morphology (MDM) proteins KH_8 PF17903.1 AET39587.1 - 8.1e-06 25.9 0.0 1.7e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 AET39587.1 - 0.064 13.1 0.4 0.14 12.0 0.4 1.6 1 0 0 1 1 1 0 KH domain AAA PF00004.29 AET39588.1 - 3e-06 27.7 0.7 0.00014 22.2 0.0 3.4 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) HTH_Tnp_Tc3_1 PF11427.8 AET39588.1 - 0.022 14.6 0.1 0.11 12.4 0.0 2.1 2 0 0 2 2 2 0 Tc3 transposase GED PF02212.18 AET39588.1 - 0.11 12.6 0.5 0.95 9.7 0.5 2.5 3 0 0 3 3 3 0 Dynamin GTPase effector domain TFIID-18kDa PF02269.16 AET39589.1 - 3.2e-36 123.2 0.4 1.8e-35 120.8 0.2 2.1 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit Ribosomal_60s PF00428.19 AET39589.1 - 0.035 14.7 0.4 0.096 13.3 0.4 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein TPK_catalytic PF04263.16 AET39590.1 - 2.5e-32 111.5 0.3 7.6e-32 109.9 0.3 1.8 1 1 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 AET39590.1 - 2.9e-14 52.5 0.1 7.3e-14 51.2 0.1 1.6 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain CoA_binding PF02629.19 AET39591.1 - 1.6e-25 89.6 3.2 1.8e-25 89.4 0.9 2.1 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 AET39591.1 - 1.1e-24 87.0 0.8 1.7e-24 86.4 0.8 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 AET39591.1 - 3e-10 40.0 0.1 5e-10 39.3 0.1 1.3 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 AET39591.1 - 5.1e-06 27.0 0.2 1.7e-05 25.3 0.0 1.9 2 0 0 2 2 2 1 CoA binding domain DASH_Ask1 PF08655.10 AET39592.1 - 1.4e-30 104.9 0.6 3.1e-30 103.9 0.6 1.6 1 0 0 1 1 1 1 DASH complex subunit Ask1 UPF0203 PF05254.12 AET39593.1 - 9.8e-28 96.2 2.4 1.1e-27 96.0 2.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.16 AET39593.1 - 0.00093 19.4 2.7 0.0017 18.5 2.7 1.5 1 1 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein Cmc1 PF08583.10 AET39593.1 - 0.001 19.0 1.7 0.13 12.3 0.1 2.1 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like EcoEI_R_C PF08463.10 AET39593.1 - 0.0013 18.9 0.0 0.0014 18.8 0.0 1.0 1 0 0 1 1 1 1 EcoEI R protein C-terminal Pet191_N PF10203.9 AET39593.1 - 0.091 13.1 2.8 1.7 9.0 0.4 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 CHCH PF06747.13 AET39593.1 - 0.14 12.4 3.8 0.17 12.0 0.7 2.1 2 0 0 2 2 2 0 CHCH domain COX17 PF05051.13 AET39593.1 - 0.15 12.5 1.7 0.65 10.4 1.8 1.8 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) adh_short PF00106.25 AET39594.1 - 1.3e-29 103.1 0.1 3.8e-21 75.4 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 AET39594.1 - 2.9e-16 59.8 0.0 5.3e-15 55.6 0.0 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 AET39594.1 - 0.0075 15.4 0.1 0.016 14.4 0.1 1.5 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 AET39594.1 - 0.011 15.7 0.1 0.081 12.8 0.0 2.2 2 0 0 2 2 2 0 KR domain Epimerase PF01370.21 AET39594.1 - 0.26 10.7 1.0 1.6 8.2 0.0 2.4 1 1 2 3 3 3 0 NAD dependent epimerase/dehydratase family TCTP PF00838.17 AET39595.1 - 2.6e-72 242.6 1.6 2.9e-72 242.4 1.6 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein RcbX PF02341.15 AET39595.1 - 0.14 12.5 0.0 0.24 11.7 0.0 1.4 1 1 0 1 1 1 0 RbcX protein Striatin PF08232.12 AET39596.1 - 2.1e-20 73.9 6.5 3.4e-20 73.2 0.6 3.1 3 0 0 3 3 3 1 Striatin family Mto2_bdg PF12808.7 AET39596.1 - 0.21 11.9 1.5 0.47 10.8 1.5 1.5 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region TPR_3 PF07720.12 AET39597.1 - 0.045 13.7 0.1 0.23 11.5 0.1 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat IKKbetaNEMObind PF12179.8 AET39597.1 - 0.073 13.1 0.2 0.46 10.6 0.2 2.5 1 0 0 1 1 1 0 I-kappa-kinase-beta NEMO binding domain DUF3916 PF13079.6 AET39597.1 - 0.13 12.1 3.5 0.7 9.8 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3916) TAP42 PF04177.12 AET39598.1 - 1.2e-78 264.4 8.7 1.4e-78 264.2 8.7 1.0 1 0 0 1 1 1 1 TAP42-like family DUF1932 PF09130.11 AET39598.1 - 0.14 12.1 0.2 0.56 10.2 0.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1932) Focal_AT PF03623.13 AET39598.1 - 0.26 11.3 2.4 2.8 7.9 0.2 2.2 2 0 0 2 2 2 0 Focal adhesion targeting region TFIIA_gamma_C PF02751.14 AET39599.1 - 6.4e-24 83.8 1.8 9.5e-24 83.3 1.8 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 AET39599.1 - 4.6e-22 77.8 0.2 6.1e-22 77.4 0.2 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain DWNN PF08783.11 AET39600.1 - 2.8e-28 98.0 0.8 4.8e-28 97.2 0.1 1.8 2 0 0 2 2 2 1 DWNN domain zf-CCHC_2 PF13696.6 AET39600.1 - 1.1e-07 31.5 8.2 4.2e-07 29.7 7.0 2.1 2 0 0 2 2 2 1 Zinc knuckle U-box PF04564.15 AET39600.1 - 0.00049 20.2 0.0 0.0061 16.7 0.0 2.4 2 0 0 2 2 2 1 U-box domain zf-CCHC PF00098.23 AET39600.1 - 0.001 19.0 3.3 0.002 18.1 3.3 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 AET39600.1 - 0.023 14.6 0.1 0.044 13.7 0.1 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-Nse PF11789.8 AET39600.1 - 0.11 12.4 0.2 0.3 11.0 0.2 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Rubredoxin PF00301.20 AET39600.1 - 0.18 11.9 4.2 7.7 6.6 0.0 2.8 3 0 0 3 3 3 0 Rubredoxin DUF89 PF01937.19 AET39601.1 - 8.8e-114 380.1 0.0 9.9e-114 380.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 F_bP_aldolase PF01116.20 AET39602.1 - 6.7e-91 304.6 0.1 7.6e-91 304.5 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Pex2_Pex12 PF04757.14 AET39603.1 - 4.4e-34 118.0 4.6 5.4e-34 117.7 4.6 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 AET39603.1 - 1e-05 25.3 0.4 1.6e-05 24.6 0.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AET39603.1 - 0.0037 17.1 0.5 0.0061 16.4 0.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AET39603.1 - 0.029 14.4 2.4 0.056 13.5 2.4 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_2 PF13639.6 AET39603.1 - 0.076 13.4 0.6 0.13 12.6 0.6 1.3 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.25 AET39603.1 - 0.088 12.7 0.6 0.14 12.0 0.6 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 AET39603.1 - 0.16 12.2 4.1 0.27 11.4 4.1 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING ISPD_C PF18706.1 AET39604.1 - 0.00052 19.7 1.0 0.00072 19.2 0.1 1.6 2 0 0 2 2 2 1 D-ribitol-5-phosphate cytidylyltransferase C-terminal domain dsrm PF00035.26 AET39605.1 - 1.7e-07 31.8 0.0 3.7e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.26 AET39605.1 - 0.00019 22.0 0.0 0.00046 20.8 0.0 1.7 1 1 0 1 1 1 1 Ribonuclease III domain MnmE_helical PF12631.7 AET39607.1 - 9.3e-42 143.5 1.4 1.2e-41 143.1 1.4 1.2 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 AET39607.1 - 2.7e-35 121.2 0.0 6.9e-35 119.8 0.0 1.7 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 AET39607.1 - 1.6e-23 83.0 0.4 1.6e-23 83.0 0.4 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AET39607.1 - 1.7e-14 53.7 1.9 1.8e-14 53.5 1.0 1.5 2 0 0 2 2 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AET39607.1 - 4.8e-08 33.1 4.0 0.0012 18.8 0.2 2.4 2 1 0 2 2 2 2 RsgA GTPase Ras PF00071.22 AET39607.1 - 1.6e-06 27.8 0.0 4.2e-06 26.5 0.0 1.7 1 1 0 1 1 1 1 Ras family Arf PF00025.21 AET39607.1 - 3.5e-06 26.6 0.8 5.8e-05 22.6 0.8 2.4 1 1 0 1 1 1 1 ADP-ribosylation factor family Dynamin_N PF00350.23 AET39607.1 - 5e-05 23.4 1.9 0.0037 17.4 0.1 2.4 1 1 1 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 AET39607.1 - 7.2e-05 22.4 0.2 0.016 14.8 0.4 2.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Roc PF08477.13 AET39607.1 - 0.0005 20.3 0.0 0.0032 17.7 0.0 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1_Xtn PF16897.5 AET39607.1 - 0.00057 19.9 0.7 0.00057 19.9 0.7 2.0 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain PduV-EutP PF10662.9 AET39607.1 - 0.001 18.8 0.1 0.024 14.4 0.1 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AIG1 PF04548.16 AET39607.1 - 0.0026 17.1 0.3 0.0047 16.3 0.3 1.4 1 0 0 1 1 1 1 AIG1 family G-alpha PF00503.20 AET39607.1 - 0.015 14.5 2.3 0.55 9.3 0.1 2.4 1 1 1 2 2 2 0 G-protein alpha subunit ABC_tran PF00005.27 AET39607.1 - 0.016 15.7 1.1 0.038 14.5 1.1 1.8 1 1 0 1 1 1 0 ABC transporter cobW PF02492.19 AET39607.1 - 0.029 14.0 1.1 2.3 7.8 0.4 2.4 1 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NOG1 PF06858.14 AET39607.1 - 0.14 11.9 0.4 0.52 10.1 0.4 2.0 1 1 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) PPV_E1_C PF00519.17 AET39607.1 - 0.17 10.7 0.0 0.56 9.0 0.0 1.7 2 0 0 2 2 2 0 Papillomavirus helicase BLI1 PF17324.2 AET39608.1 - 4.5e-28 98.1 2.5 5.2e-28 97.9 2.5 1.0 1 0 0 1 1 1 1 BLOC-1 interactor 1 BLOC1_2 PF10046.9 AET39608.1 - 0.0012 19.1 0.9 0.0023 18.2 0.8 1.7 1 1 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 AFP_2 PF18815.1 AET39608.1 - 0.1 12.8 0.1 0.28 11.4 0.0 1.8 1 1 0 1 1 1 0 Bacterial antifreeze protein repeat DUF2347 PF09804.9 AET39609.1 - 1.1e-74 251.6 0.1 1.5e-74 251.2 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.6 AET39609.1 - 4.8e-10 39.8 6.1 8.1e-06 26.0 0.0 3.2 1 1 2 3 3 3 3 Domain of unknown function (DUF4484) Avl9 PF09794.9 AET39609.1 - 2.4e-06 26.5 0.0 0.00079 18.2 0.0 2.8 3 0 0 3 3 3 2 Transport protein Avl9 SPA PF08616.10 AET39609.1 - 0.0021 18.0 0.0 0.0047 16.9 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Glyco_hydro_76 PF03663.14 AET39610.1 - 8.5e-153 509.2 11.4 9.8e-153 509.0 11.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 AET39610.1 - 0.98 8.4 10.7 16 4.4 8.5 2.9 1 1 1 2 2 2 0 Glycosyl Hydrolase Family 88 UQ_con PF00179.26 AET39611.1 - 3.3e-48 162.9 0.0 3.7e-48 162.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Copper-fist PF00649.18 AET39612.1 - 2.1e-20 71.9 2.1 5.8e-20 70.5 2.1 1.8 1 0 0 1 1 1 1 Copper fist DNA binding domain DUF4696 PF15767.5 AET39612.1 - 0.044 12.4 0.0 0.065 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4696) MRI PF15325.6 AET39612.1 - 0.2 12.7 0.0 0.2 12.7 0.0 2.5 2 1 1 3 3 3 0 Modulator of retrovirus infection Amino_oxidase PF01593.24 AET39613.1 - 1.6e-48 166.1 0.0 3.5e-48 165.0 0.0 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 AET39613.1 - 2.8e-10 40.3 0.1 6e-10 39.2 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 AET39613.1 - 1.7e-05 24.2 0.2 0.012 14.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AET39613.1 - 0.00014 21.2 0.7 0.078 12.2 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 AET39613.1 - 0.00081 19.1 1.3 0.003 17.2 1.3 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 AET39613.1 - 0.0026 17.1 0.2 0.0047 16.2 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 AET39613.1 - 0.0065 15.6 0.3 0.013 14.6 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 AET39613.1 - 0.061 13.3 0.2 13 5.8 0.1 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding DNA_primase_lrg PF04104.14 AET39614.1 - 3.7e-80 269.1 0.0 5.9e-80 268.5 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Mrr_N PF14338.6 AET39614.1 - 0.14 12.3 0.5 0.6 10.3 0.3 2.2 2 0 0 2 2 2 0 Mrr N-terminal domain KilA-N PF04383.13 AET39617.1 - 0.00093 19.0 0.0 0.00093 19.0 0.0 2.8 2 1 0 2 2 2 1 KilA-N domain Spc42p PF11544.8 AET39618.1 - 1e-23 83.1 4.7 1e-23 83.1 4.7 4.2 3 1 1 4 4 4 2 Spindle pole body component Spc42p PhoU PF01895.19 AET39618.1 - 0.013 15.9 4.5 3.1 8.3 0.1 3.2 3 0 0 3 3 3 0 PhoU domain DivIVA PF05103.13 AET39618.1 - 0.017 15.2 5.1 0.017 15.2 5.1 2.5 1 1 1 2 2 2 0 DivIVA protein V_ATPase_I PF01496.19 AET39618.1 - 1 7.2 13.4 0.64 7.9 11.0 1.5 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family LMBR1 PF04791.16 AET39618.1 - 1.9 7.3 14.1 0.34 9.8 10.7 1.4 1 1 0 1 1 1 0 LMBR1-like membrane protein BUD22 PF09073.10 AET39619.1 - 6.4e-86 289.4 29.6 6.4e-86 289.4 29.6 1.3 2 0 0 2 2 2 1 BUD22 Phycoerythr_ab PF02972.14 AET39619.1 - 0.13 12.1 0.9 11 5.9 0.2 2.9 2 0 0 2 2 2 0 Phycoerythrin, alpha/beta chain CTP_transf_1 PF01148.20 AET39620.1 - 1.1 8.9 22.8 0.028 14.2 6.5 3.2 1 1 0 3 3 3 0 Cytidylyltransferase family Snf7 PF03357.21 AET39621.1 - 5.3e-27 94.5 29.2 2.4e-26 92.4 29.1 1.8 1 1 0 1 1 1 1 Snf7 CRR7 PF12095.8 AET39621.1 - 0.07 13.6 0.1 0.07 13.6 0.1 3.3 2 1 2 4 4 4 0 Protein CHLORORESPIRATORY REDUCTION 7 DNA_photolyase PF00875.18 AET39621.1 - 0.28 11.2 2.1 0.28 11.2 0.1 2.0 2 1 0 2 2 2 0 DNA photolyase Opi1 PF08618.10 AET39622.1 - 1.2e-33 117.0 1.1 2.4e-21 76.5 0.1 3.1 2 1 1 3 3 3 3 Transcription factor Opi1 DUF4615 PF15393.6 AET39622.1 - 0.023 15.3 2.0 0.023 15.3 2.0 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4615) bact-PGI_C PF10432.9 AET39622.1 - 0.035 14.1 0.7 4.5 7.3 0.0 3.1 3 0 0 3 3 3 0 Bacterial phospho-glucose isomerase C-terminal SIS domain Ribosomal_S13 PF00416.22 AET39622.1 - 0.036 14.4 0.6 0.036 14.4 0.6 2.8 3 0 0 3 3 3 0 Ribosomal protein S13/S18 Adap_comp_sub PF00928.21 AET39623.1 - 5.6e-63 212.8 0.3 8.2e-63 212.2 0.3 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Pterin_4a PF01329.19 AET39624.1 - 3.2e-25 88.1 0.0 4e-25 87.8 0.0 1.1 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase NifU PF01106.17 AET39625.1 - 1e-25 89.7 0.0 1.7e-25 88.9 0.0 1.4 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.11 AET39625.1 - 3.2e-24 84.8 0.0 2e-23 82.2 0.0 2.2 3 0 0 3 3 3 1 Scaffold protein Nfu/NifU N terminal YojJ PF10372.9 AET39625.1 - 0.0071 16.4 2.9 0.0071 16.4 2.9 1.6 2 0 0 2 2 2 1 Bacterial membrane-spanning protein N-terminus Lung_7-TM_R PF06814.13 AET39626.1 - 3.2e-67 226.9 19.5 4.2e-67 226.5 19.5 1.2 1 0 0 1 1 1 1 Lung seven transmembrane receptor SSF PF00474.17 AET39627.1 - 1.6e-16 60.2 32.2 1.6e-16 60.2 32.2 2.0 2 0 0 2 2 2 1 Sodium:solute symporter family DUF3087 PF11286.8 AET39627.1 - 0.12 11.9 0.8 0.58 9.6 0.8 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3087) Ribosomal_S10 PF00338.22 AET39628.1 - 6.6e-25 87.2 0.3 7.8e-25 87.0 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Sipho_Gp157 PF05565.11 AET39628.1 - 0.014 15.5 0.1 0.023 14.7 0.1 1.3 1 1 0 1 1 1 0 Siphovirus Gp157 GBR2_CC PF18455.1 AET39628.1 - 0.034 14.3 0.1 0.1 12.8 0.1 1.7 1 0 0 1 1 1 0 Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain Retrotrans_gag PF03732.17 AET39628.1 - 0.065 13.5 0.0 0.1 12.9 0.0 1.5 1 1 0 1 1 1 0 Retrotransposon gag protein YchF-GTPase_C PF06071.13 AET39629.1 - 6.8e-32 109.5 0.0 1.6e-31 108.3 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 AET39629.1 - 1.7e-15 57.1 0.0 5.7e-15 55.4 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AET39629.1 - 0.00023 20.7 0.0 0.00044 19.8 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B TGS PF02824.21 AET39629.1 - 0.0062 16.6 0.0 0.016 15.3 0.0 1.6 1 0 0 1 1 1 1 TGS domain DUF4609 PF15382.6 AET39629.1 - 0.13 12.2 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4609) OTU PF02338.19 AET39630.1 - 1.6e-22 80.4 2.5 2.4e-22 79.8 0.3 2.3 2 1 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 AET39630.1 - 0.00094 18.7 0.8 0.083 12.3 0.0 2.8 3 0 0 3 3 3 2 Peptidase C65 Otubain Cep57_MT_bd PF06657.13 AET39630.1 - 0.0036 17.7 5.3 0.011 16.1 5.3 1.9 1 0 0 1 1 1 1 Centrosome microtubule-binding domain of Cep57 RepB-RCR_reg PF10723.9 AET39630.1 - 0.069 13.1 0.8 0.16 11.9 0.0 1.9 2 0 0 2 2 2 0 Replication regulatory protein RepB DUF810 PF05664.11 AET39631.1 - 0.18 10.3 2.0 0.49 8.9 1.2 1.7 1 1 1 2 2 2 0 Plant family of unknown function (DUF810) RPM2 PF08579.11 AET39632.1 - 2.2e-48 163.6 3.5 2.1e-47 160.4 1.1 3.2 2 0 0 2 2 2 1 Mitochondrial ribonuclease P subunit (RPM2) PPR_2 PF13041.6 AET39632.1 - 0.00088 19.4 0.4 2 8.7 0.0 5.0 6 0 0 6 6 6 1 PPR repeat family PPR PF01535.20 AET39632.1 - 0.018 15.3 0.1 0.27 11.6 0.1 3.2 2 0 0 2 2 2 0 PPR repeat IL3 PF02059.15 AET39632.1 - 0.056 13.5 0.4 3.7 7.7 0.0 3.1 2 0 0 2 2 2 0 Interleukin-3 PPR_3 PF13812.6 AET39632.1 - 0.12 12.5 7.1 0.16 12.1 0.1 4.3 6 0 0 6 6 6 0 Pentatricopeptide repeat domain PPR_1 PF12854.7 AET39632.1 - 0.3 10.8 1.1 3.7 7.3 0.0 3.3 4 0 0 4 4 4 0 PPR repeat RST PF12174.8 AET39632.1 - 0.41 10.6 1.7 45 4.1 0.0 3.2 3 0 0 3 3 3 0 RCD1-SRO-TAF4 (RST) plant domain HMG_CoA_synt_C PF08540.10 AET39633.1 - 7e-110 367.0 0.8 8.6e-110 366.8 0.8 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 AET39633.1 - 2e-95 317.6 0.5 2.8e-95 317.1 0.5 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal Ubie_methyltran PF01209.18 AET39634.1 - 4.1e-91 304.5 0.1 4.8e-91 304.2 0.1 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 AET39634.1 - 2.8e-11 44.0 0.0 5.6e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AET39634.1 - 1.3e-09 38.0 0.0 6.3e-09 35.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AET39634.1 - 1.7e-09 38.2 0.0 3e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AET39634.1 - 3.3e-08 34.2 0.0 5.4e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AET39634.1 - 0.00012 22.0 0.0 0.0002 21.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 AET39634.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Hypothetical methyltransferase CTK3_C PF12350.8 AET39635.1 - 3.3e-16 59.2 4.6 7.8e-16 58.0 4.6 1.6 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 C-terminus CTK3 PF12243.8 AET39635.1 - 8.8e-06 25.7 0.1 5.8e-05 23.1 0.0 2.3 2 1 0 2 2 2 1 CTD kinase subunit gamma CTK3 XPG_N PF00752.17 AET39635.1 - 0.053 14.0 0.3 0.45 11.0 0.1 2.2 2 0 0 2 2 2 0 XPG N-terminal domain NDUFB11 PF17250.2 AET39635.1 - 0.14 12.8 0.9 0.34 11.6 0.4 1.8 1 1 0 1 1 1 0 NADH-ubiquinone oxidoreductase 11 kDa subunit ubiquitin PF00240.23 AET39637.1 - 5e-22 77.4 0.0 8.1e-22 76.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 AET39637.1 - 4.1e-10 39.3 0.0 6.5e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.31 AET39637.1 - 8.4e-07 28.8 0.2 2.5e-06 27.3 0.2 1.9 1 0 0 1 1 1 1 UBA/TS-N domain Ubiquitin_2 PF14560.6 AET39637.1 - 0.00071 20.0 0.0 0.0016 18.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 AET39637.1 - 0.0092 16.1 0.0 0.02 15.0 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like HOIP-UBA PF16678.5 AET39637.1 - 0.012 15.6 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 HOIP UBA domain pair DUF2407 PF10302.9 AET39637.1 - 0.11 13.1 0.0 0.2 12.2 0.0 1.4 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain TAF8_C PF10406.9 AET39638.1 - 4.8e-18 65.5 0.2 4.8e-18 65.5 0.2 2.4 2 0 0 2 2 2 1 Transcription factor TFIID complex subunit 8 C-term NIF PF03031.18 AET39639.1 - 1.2e-22 80.3 0.1 4.9e-22 78.4 0.0 2.1 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase BRCT PF00533.26 AET39639.1 - 2.2e-12 47.2 0.6 5.8e-12 45.8 0.3 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 AET39639.1 - 1.1e-05 25.3 0.0 2.5e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 AET39639.1 - 0.00011 22.6 0.0 0.0003 21.1 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Biotin_lipoyl_2 PF13533.6 AET39639.1 - 0.00021 21.1 0.0 0.2 11.5 0.0 2.6 2 0 0 2 2 2 2 Biotin-lipoyl like HlyD_3 PF13437.6 AET39639.1 - 0.03 15.0 0.0 2.9 8.6 0.0 2.8 2 0 0 2 2 2 0 HlyD family secretion protein LIG3_BRCT PF16759.5 AET39639.1 - 0.061 13.6 0.2 0.26 11.6 0.0 2.2 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain PGM_PMM_I PF02878.16 AET39640.1 - 6.2e-38 129.6 0.1 1.6e-37 128.3 0.1 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 AET39640.1 - 6.9e-20 71.6 0.0 1.6e-19 70.4 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 AET39640.1 - 3e-16 59.6 0.0 5.7e-16 58.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 AET39640.1 - 2.1e-05 24.6 0.0 5.3e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Usp PF00582.26 AET39640.1 - 0.2 12.2 0.0 1.5 9.3 0.0 2.2 2 0 0 2 2 2 0 Universal stress protein family S-methyl_trans PF02574.16 AET39641.1 - 3.8e-58 197.4 0.0 4.4e-58 197.2 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Anp1 PF03452.14 AET39642.1 - 1.9e-117 391.4 0.1 2.8e-117 390.8 0.1 1.2 1 0 0 1 1 1 1 Anp1 Asp PF00026.23 AET39643.1 - 2.5e-46 158.6 0.9 3.3e-46 158.2 0.9 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AET39643.1 - 2.9e-06 27.6 0.1 0.00053 20.3 0.1 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 AET39643.1 - 5e-06 26.4 0.0 1.4e-05 25.0 0.0 1.7 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 AET39643.1 - 0.093 13.4 0.0 2.5 8.8 0.0 2.8 2 1 0 2 2 2 0 Aspartyl protease Nab6_mRNP_bdg PF10567.9 AET39644.1 - 7.8e-66 222.7 10.0 4.1e-65 220.3 10.0 2.3 1 1 0 1 1 1 1 RNA-recognition motif RRM PF10378.9 AET39644.1 - 7.1e-21 73.7 10.6 4.3e-20 71.2 10.6 2.5 1 0 0 1 1 1 1 Putative RRM domain RRM_1 PF00076.22 AET39644.1 - 8.3e-06 25.5 0.4 0.034 13.9 0.0 3.9 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fungal_trans PF04082.18 AET39645.1 - 1.7e-41 142.0 0.5 1.7e-41 142.0 0.5 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET39645.1 - 2e-10 40.6 13.0 3.8e-10 39.7 13.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Spt20 PF12090.8 AET39645.1 - 0.0026 17.4 4.0 0.0026 17.4 4.0 5.6 8 0 0 8 8 8 1 Spt20 family SUIM_assoc PF16619.5 AET39645.1 - 0.0031 17.5 8.6 0.0031 17.5 8.6 4.9 5 0 0 5 5 5 1 Unstructured region C-term to UIM in Ataxin3 PIG-L PF02585.17 AET39646.1 - 6.9e-24 85.0 0.2 9.9e-24 84.4 0.2 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase baeRF_family2 PF18844.1 AET39646.1 - 0.035 14.2 1.0 0.045 13.8 1.0 1.3 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 2 TMEM107 PF14995.6 AET39646.1 - 0.14 12.6 4.6 0.099 13.1 1.4 2.1 2 0 0 2 2 2 0 Transmembrane protein ATP13 PF12921.7 AET39647.1 - 4.2e-31 107.2 0.0 1.9e-30 105.0 0.0 2.3 2 0 0 2 2 2 1 Mitochondrial ATPase expression BaffR-Tall_bind PF09256.10 AET39647.1 - 0.024 14.4 0.0 0.043 13.6 0.0 1.4 1 0 0 1 1 1 0 BAFF-R, TALL-1 binding Exo_endo_phos PF03372.23 AET39648.1 - 6.9e-28 97.7 0.0 8.9e-28 97.4 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Corona_S1 PF01600.16 AET39648.1 - 0.057 12.2 0.0 0.1 11.4 0.0 1.3 1 0 0 1 1 1 0 Coronavirus S1 glycoprotein Ku PF02735.16 AET39649.1 - 1.6e-29 103.1 0.1 3.5e-29 102.0 0.1 1.5 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 AET39649.1 - 4.9e-11 42.8 2.3 1.1e-10 41.6 2.3 1.6 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain TMEM251 PF15190.6 AET39649.1 - 0.079 12.9 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 Transmembrane protein 251 DUF465 PF04325.13 AET39649.1 - 2.6 8.2 5.0 5.5 7.1 0.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF465) AA_permease_2 PF13520.6 AET39650.1 - 1.1e-58 199.1 61.2 1.4e-58 198.8 61.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AET39650.1 - 8.9e-14 50.9 52.0 1.4e-13 50.3 52.0 1.2 1 0 0 1 1 1 1 Amino acid permease Glycophorin_A PF01102.18 AET39650.1 - 0.16 12.2 0.2 0.16 12.2 0.2 1.8 2 0 0 2 2 2 0 Glycophorin A SCIMP PF15050.6 AET39650.1 - 0.18 12.3 0.1 0.54 10.7 0.1 1.8 1 0 0 1 1 1 0 SCIMP protein Rit1_C PF17184.4 AET39651.1 - 2.3e-95 319.1 0.0 4.1e-95 318.3 0.0 1.4 1 0 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 AET39651.1 - 5.7e-27 94.2 0.6 5.7e-27 94.2 0.6 2.3 2 0 0 2 2 2 1 Rit1 DUSP-like domain DUF3567 PF12091.8 AET39651.1 - 0.12 12.5 0.0 0.32 11.1 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3567) Ribosomal_L30 PF00327.20 AET39652.1 - 6.3e-16 58.0 0.1 8.3e-16 57.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Phi29_Phage_SSB PF17427.2 AET39652.1 - 0.06 13.5 0.0 0.06 13.5 0.0 1.1 1 0 0 1 1 1 0 Phage Single-stranded DNA-binding protein Ribosomal_60s PF00428.19 AET39653.1 - 9.3e-27 93.5 10.8 1.1e-26 93.3 10.8 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein Mito_carr PF00153.27 AET39654.1 - 2.5e-59 197.2 5.6 1.6e-22 79.2 0.3 3.2 3 1 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.27 AET39655.1 - 2.5e-49 165.1 5.9 2.6e-16 59.3 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein AIRC PF00731.20 AET39657.1 - 1.4e-63 212.9 1.2 3e-63 211.8 1.2 1.6 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 AET39657.1 - 7.3e-59 198.2 0.0 1.2e-58 197.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 AET39657.1 - 1.5e-17 63.0 0.0 3.5e-17 61.8 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain AlaDh_PNT_C PF01262.21 AET39657.1 - 0.00049 19.4 0.9 0.0013 18.1 0.9 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 AET39657.1 - 0.0041 16.5 0.1 0.008 15.6 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CPSase_L_D2 PF02786.17 AET39657.1 - 0.036 13.6 0.0 0.061 12.8 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 AET39657.1 - 0.069 12.7 0.0 0.36 10.3 0.0 2.0 1 1 0 1 1 1 0 D-ala D-ala ligase C-terminus PALP PF00291.25 AET39657.1 - 0.083 12.3 2.0 0.68 9.3 0.2 2.3 2 0 0 2 2 2 0 Pyridoxal-phosphate dependent enzyme Zn_clus PF00172.18 AET39658.1 - 5e-09 36.1 6.2 1.2e-08 35.0 6.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_transf_21 PF13506.6 AET39659.1 - 1.5e-20 73.4 0.0 4.1e-16 58.9 0.0 2.5 2 1 0 2 2 2 2 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 AET39659.1 - 5.2e-11 42.9 0.0 1.1e-09 38.5 0.0 2.1 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 AET39659.1 - 2.4e-05 24.2 0.0 4.1e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Complex1_LYR PF05347.15 AET39660.1 - 8.1e-14 51.4 0.6 9.4e-14 51.2 0.6 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 AET39660.1 - 0.13 13.1 0.2 0.15 12.9 0.2 1.2 1 0 0 1 1 1 0 Complex1_LYR-like RhoGAP PF00620.27 AET39661.1 - 9.1e-43 145.7 0.2 2.3e-42 144.4 0.2 1.7 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 AET39661.1 - 1.1e-12 48.0 26.2 3.7e-06 27.1 9.7 2.7 2 0 0 2 2 2 2 LIM domain PDDEXK_6 PF04720.12 AET39661.1 - 0.35 10.8 2.1 0.98 9.3 2.1 1.8 1 0 0 1 1 1 0 PDDEXK-like family of unknown function Rhabdo_ncap PF00945.18 AET39661.1 - 0.46 9.3 2.4 0.71 8.7 2.4 1.2 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein DNA_pol_phi PF04931.13 AET39661.1 - 0.54 8.3 10.7 0.89 7.6 10.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 AET39661.1 - 0.69 9.6 5.8 1.8 8.2 5.8 1.7 1 0 0 1 1 1 0 FAM176 family RRN3 PF05327.11 AET39661.1 - 6.6 5.1 11.2 15 4.0 11.2 1.5 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 LSM PF01423.22 AET39662.1 - 1.2e-16 60.1 0.0 1.4e-16 59.9 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AET39662.1 - 0.00019 21.5 0.1 0.00022 21.3 0.1 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 AET39662.1 - 0.002 18.2 0.0 0.0026 17.8 0.0 1.3 1 1 0 1 1 1 1 Scd6-like Sm domain F1F0-ATPsyn_F PF10791.9 AET39663.1 - 1.4e-40 137.6 0.2 1.6e-40 137.4 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi Pyr_redox_2 PF07992.14 AET39664.1 - 6.7e-09 35.4 0.0 2.5e-06 27.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AET39664.1 - 4.6e-05 23.6 0.0 0.00013 22.1 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 AET39664.1 - 0.0011 19.0 0.0 0.0031 17.5 0.0 1.8 2 0 0 2 2 2 1 FAD-NAD(P)-binding Shikimate_DH PF01488.20 AET39664.1 - 0.035 14.2 0.0 2.3 8.3 0.0 2.8 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase DAO PF01266.24 AET39664.1 - 0.11 12.0 0.0 0.29 10.7 0.0 1.7 1 1 0 1 1 1 0 FAD dependent oxidoreductase Lipase_GDSL_2 PF13472.6 AET39665.1 - 4.9e-22 79.2 0.0 6.4e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 AET39665.1 - 9.5e-16 58.4 0.0 1.7e-15 57.6 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase BCS1_N PF08740.11 AET39666.1 - 1.6e-46 158.6 0.1 2.4e-46 158.1 0.1 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 AET39666.1 - 5.7e-20 72.1 0.0 5.4e-19 68.9 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AET39666.1 - 0.0012 19.3 0.0 0.0032 17.9 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 AET39666.1 - 0.0046 16.7 0.0 0.0081 15.9 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 AET39666.1 - 0.0047 16.9 0.0 0.01 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 AET39666.1 - 0.005 16.4 0.0 0.031 13.8 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_18 PF13238.6 AET39666.1 - 0.0083 16.7 0.0 0.017 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 AET39666.1 - 0.021 14.6 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 AET39666.1 - 0.027 14.2 0.0 0.067 12.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 AET39666.1 - 0.032 14.4 0.0 0.071 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AET39666.1 - 0.041 14.2 0.0 0.099 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AET39666.1 - 0.046 14.2 0.0 0.093 13.2 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_25 PF13481.6 AET39666.1 - 0.051 13.2 0.0 0.25 10.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 AET39666.1 - 0.058 13.4 0.0 0.36 10.9 0.0 2.4 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 AET39666.1 - 0.061 13.7 0.0 0.14 12.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_21 PF13304.6 AET39666.1 - 0.064 13.1 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system ATPase PF06745.13 AET39666.1 - 0.069 12.5 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 KaiC ATP_bind_1 PF03029.17 AET39666.1 - 0.071 12.9 0.1 1.1 9.0 0.1 2.2 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein NACHT PF05729.12 AET39666.1 - 0.097 12.6 0.0 0.33 10.9 0.0 1.9 1 0 0 1 1 1 0 NACHT domain Gram_pos_anchor PF00746.21 AET39666.1 - 0.15 12.1 0.3 0.28 11.2 0.3 1.4 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Rad17 PF03215.15 AET39666.1 - 0.15 12.0 0.0 0.55 10.1 0.0 2.0 1 1 1 2 2 2 0 Rad17 P-loop domain TsaE PF02367.17 AET39666.1 - 0.17 11.9 0.0 0.36 10.8 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 AET39666.1 - 0.24 11.2 0.0 0.39 10.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain WD40 PF00400.32 AET39667.1 - 5e-18 65.1 19.3 0.0002 22.1 0.5 6.7 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET39667.1 - 1.1e-05 25.6 3.9 0.39 11.1 0.5 4.5 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain PNP_UDP_1 PF01048.20 AET39668.1 - 3e-45 154.3 0.0 3.5e-45 154.1 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily DEAD PF00270.29 AET39669.1 - 1.1e-44 152.3 0.0 1.7e-44 151.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET39669.1 - 4.7e-30 104.2 0.3 7.5e-29 100.3 0.4 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Phage_integrase PF00589.22 AET39669.1 - 0.13 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Phage integrase family Pkinase PF00069.25 AET39670.1 - 9e-66 221.9 0.0 1.3e-65 221.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET39670.1 - 2.8e-39 135.0 0.0 3.8e-39 134.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AET39670.1 - 0.00046 19.1 0.0 0.00046 19.1 0.0 2.2 3 0 0 3 3 3 1 Fungal protein kinase Haspin_kinase PF12330.8 AET39670.1 - 0.0013 17.7 2.2 0.0013 17.7 2.2 2.6 2 1 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 AET39670.1 - 0.0014 18.1 0.0 0.003 16.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like WD40 PF00400.32 AET39672.1 - 1e-09 38.8 1.0 0.19 12.7 0.0 5.8 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET39672.1 - 2.7e-05 24.4 0.0 0.047 14.0 0.0 2.9 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain zf-HC5HC2H_2 PF13832.6 AET39673.1 - 1.4e-30 105.7 7.1 1.4e-30 105.7 7.1 2.8 3 0 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 AET39673.1 - 3.5e-27 94.5 4.8 3.5e-27 94.5 4.8 3.2 2 1 1 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 AET39673.1 - 5e-14 51.6 3.6 5e-14 51.6 3.6 2.3 2 0 0 2 2 2 1 PHD-finger EPL1 PF10513.9 AET39673.1 - 2.1e-13 50.9 0.1 4.5e-13 49.9 0.1 1.6 1 0 0 1 1 1 1 Enhancer of polycomb-like PHD PF00628.29 AET39673.1 - 2.7e-11 43.2 18.9 4.4e-11 42.5 4.0 2.8 2 0 0 2 2 2 2 PHD-finger zf-RING-like PF08746.11 AET39673.1 - 0.038 14.3 17.3 0.2 12.0 8.7 2.6 2 0 0 2 2 2 0 RING-like domain HEPN_Swt1 PF18731.1 AET39673.1 - 0.087 13.2 0.8 0.22 11.9 0.2 1.9 2 0 0 2 2 2 0 Swt1-like HEPN C1_1 PF00130.22 AET39673.1 - 0.099 12.5 0.2 0.099 12.5 0.2 2.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 AET39673.1 - 0.13 12.2 19.6 0.054 13.4 4.6 3.0 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 C1_2 PF03107.16 AET39673.1 - 9 6.7 22.0 0.29 11.5 2.8 3.2 3 0 0 3 3 3 0 C1 domain Pkinase PF00069.25 AET39674.1 - 1.2e-60 205.1 2.2 2.8e-60 203.9 0.0 2.4 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET39674.1 - 1.2e-35 123.1 0.0 2.7e-35 121.9 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase HR1 PF02185.16 AET39674.1 - 2.1e-20 72.6 28.9 3.2e-13 49.6 5.7 3.4 4 0 0 4 4 4 2 Hr1 repeat C1_1 PF00130.22 AET39674.1 - 6.1e-19 67.6 36.2 5.1e-11 42.3 15.2 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 AET39674.1 - 2.2e-11 44.3 0.4 9.2e-11 42.3 0.4 2.2 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 AET39674.1 - 0.011 15.1 6.4 0.026 13.9 0.0 3.4 3 1 0 4 4 4 0 Kinase-like YrbL-PhoP_reg PF10707.9 AET39674.1 - 0.063 12.8 0.0 10 5.6 0.0 2.7 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Methyltr_RsmB-F PF01189.17 AET39674.1 - 0.067 12.8 0.2 0.15 11.7 0.2 1.6 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Pkinase_fungal PF17667.1 AET39674.1 - 0.08 11.7 0.0 0.08 11.7 0.0 2.3 4 0 0 4 4 4 0 Fungal protein kinase C1_2 PF03107.16 AET39674.1 - 4.6 7.6 29.1 2.3 8.6 6.8 2.6 2 0 0 2 2 2 0 C1 domain Lgl_C PF08596.10 AET39675.1 - 5.6e-119 397.3 0.2 1.2e-118 396.3 0.1 1.6 2 0 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal ANAPC4_WD40 PF12894.7 AET39675.1 - 1.2e-05 25.5 0.5 0.2 12.0 0.0 5.9 5 2 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AET39675.1 - 0.0038 18.0 0.3 21 6.2 0.0 5.2 5 0 0 5 5 5 1 WD domain, G-beta repeat LLGL PF08366.13 AET39675.1 - 0.011 16.1 0.6 0.65 10.4 0.0 3.2 2 1 0 2 2 2 0 LLGL2 Utp8 PF10395.9 AET39675.1 - 0.036 12.6 3.3 0.038 12.5 0.4 2.2 2 0 0 2 2 2 0 Utp8 family Cid2 PF09774.9 AET39676.1 - 9.5e-33 113.9 0.1 1.2e-32 113.5 0.1 1.1 1 0 0 1 1 1 1 Caffeine-induced death protein 2 IDO PF01231.18 AET39677.1 - 7.4e-141 469.8 0.0 8.7e-141 469.6 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase tRNA-synt_His PF13393.6 AET39678.1 - 1.5e-36 126.2 0.0 1.2e-35 123.3 0.0 2.0 1 1 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 AET39678.1 - 2.1e-15 56.6 0.0 4.3e-15 55.6 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 AET39678.1 - 0.019 14.5 0.2 0.075 12.5 0.0 1.9 2 0 0 2 2 2 0 Anticodon binding domain of tRNAs AIM24 PF01987.17 AET39679.1 - 4.5e-37 127.8 0.0 6.1e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 NuA4 PF09340.10 AET39680.1 - 8.3e-23 80.1 1.7 1.1e-22 79.7 1.7 1.2 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 RNase_J_C PF17770.1 AET39680.1 - 0.19 12.8 1.5 0.29 12.2 1.5 1.4 1 0 0 1 1 1 0 Ribonuclease J C-terminal domain Thioredoxin_4 PF13462.6 AET39681.1 - 2e-07 31.3 0.0 3.3e-07 30.6 0.0 1.3 1 1 0 1 1 1 1 Thioredoxin Ribosomal_S17_N PF16205.5 AET39681.1 - 0.087 13.2 0.0 2.1 8.8 0.0 2.4 2 0 0 2 2 2 0 Ribosomal_S17 N-terminal Gln-synt_C PF00120.24 AET39682.1 - 1.8e-20 73.2 0.0 4.7e-15 55.4 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 AET39682.1 - 7.9e-13 47.9 0.0 1.4e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain V-ATPase_H_N PF03224.14 AET39683.1 - 1.1e-69 235.2 11.3 1.1e-69 235.2 11.3 1.9 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 AET39683.1 - 4.9e-40 136.3 8.3 7.4e-40 135.7 1.9 2.8 2 0 0 2 2 2 1 V-ATPase subunit H Sec23_helical PF04815.15 AET39683.1 - 0.094 12.5 0.4 0.42 10.4 0.4 2.2 1 0 0 1 1 1 0 Sec23/Sec24 helical domain Exotox-A_cataly PF09009.10 AET39683.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Exotoxin A catalytic HEAT PF02985.22 AET39683.1 - 0.15 12.4 1.2 17 6.0 0.0 4.1 5 0 0 5 5 5 0 HEAT repeat Sec2p PF06428.11 AET39684.1 - 1.2 9.1 8.7 2.5 8.1 0.7 3.4 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p PCI PF01399.27 AET39685.1 - 1.1e-06 29.1 0.0 2.1e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 PCI domain ABC2_membrane_6 PF06182.11 AET39685.1 - 0.0069 16.2 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein Tmemb_14 PF03647.13 AET39687.1 - 9.6e-23 80.7 5.3 1.1e-22 80.6 5.3 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C Aim19 PF10315.9 AET39687.1 - 0.0012 19.1 1.2 0.0017 18.6 1.2 1.3 1 1 0 1 1 1 1 Altered inheritance of mitochondria protein 19 DUF4131 PF13567.6 AET39687.1 - 0.0082 15.8 0.1 0.01 15.5 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) ATPase_gene1 PF09527.10 AET39687.1 - 1.7 8.8 8.6 0.46 10.7 1.6 2.8 2 1 1 3 3 3 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter G-gamma PF00631.22 AET39688.1 - 8.5e-27 93.0 0.0 9.8e-27 92.8 0.0 1.1 1 0 0 1 1 1 1 GGL domain Evr1_Alr PF04777.13 AET39689.1 - 2.7e-24 85.5 0.1 4.2e-24 84.9 0.1 1.3 1 0 0 1 1 1 1 Erv1 / Alr family APOBEC1 PF18769.1 AET39689.1 - 0.11 12.8 0.1 0.18 12.0 0.1 1.4 1 0 0 1 1 1 0 APOBEC1 TIP41 PF04176.13 AET39690.1 - 7.2e-68 227.4 1.7 1.3e-67 226.6 1.4 1.5 2 0 0 2 2 2 1 TIP41-like family TPR_2 PF07719.17 AET39691.1 - 3.2e-06 26.8 2.5 0.0002 21.3 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 AET39691.1 - 0.0012 18.9 1.2 0.34 11.2 0.0 4.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 AET39691.1 - 0.0021 17.8 0.1 0.2 11.5 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 AET39691.1 - 0.0046 17.7 0.3 1.8 9.6 0.0 3.8 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 AET39691.1 - 0.017 15.3 0.4 0.049 13.8 0.1 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 AET39691.1 - 0.022 15.4 0.3 21 6.0 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 AET39691.1 - 0.046 14.1 0.2 23 5.7 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 AET39691.1 - 0.055 13.8 0.5 6.4 7.1 0.0 3.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 AET39691.1 - 0.087 13.4 0.0 4.5 7.9 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 AET39691.1 - 0.15 12.0 0.9 2.3 8.2 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat eIF-5_eIF-2B PF01873.17 AET39692.1 - 1.6e-38 131.1 0.0 2.9e-38 130.3 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 AET39692.1 - 2.9e-21 75.4 0.0 9e-20 70.6 0.0 2.5 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon UPF0231 PF06062.11 AET39692.1 - 0.18 12.1 2.0 3.1 8.1 0.2 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0231) Zn-ribbon_8 PF09723.10 AET39692.1 - 0.19 11.9 0.8 0.48 10.6 0.8 1.7 1 0 0 1 1 1 0 Zinc ribbon domain LRR_4 PF12799.7 AET39694.1 - 2.4e-05 24.6 13.0 3.1 8.3 0.2 7.2 5 2 2 7 7 7 4 Leucine Rich repeats (2 copies) F-box-like PF12937.7 AET39694.1 - 2.9e-05 23.9 0.1 6.5e-05 22.7 0.1 1.6 1 0 0 1 1 1 1 F-box-like Preseq_ALAS PF09029.10 AET39694.1 - 0.015 15.8 0.3 0.087 13.3 0.0 2.5 2 0 0 2 2 2 0 5-aminolevulinate synthase presequence F-box PF00646.33 AET39694.1 - 0.035 14.0 0.5 0.11 12.4 0.0 2.2 2 0 0 2 2 2 0 F-box domain SPAM PF02090.15 AET39694.1 - 0.15 11.9 2.3 0.46 10.3 2.3 1.9 1 0 0 1 1 1 0 Salmonella surface presentation of antigen gene type M protein Nucleoporin_C PF03177.14 AET39695.1 - 5.9e-131 438.1 6.5 2.2e-129 432.9 6.5 2.2 1 1 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 AET39695.1 - 6.1e-131 437.2 12.8 1.2e-130 436.2 12.8 1.5 1 0 0 1 1 1 1 Nup133 N terminal like SUIM_assoc PF16619.5 AET39695.1 - 0.13 12.4 15.2 0.47 10.6 6.4 3.1 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 AET39695.1 - 0.28 11.1 12.2 0.51 10.3 12.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hydin_ADK PF17213.3 AET39695.1 - 0.84 9.9 7.1 1.7 8.9 7.1 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Atg8 PF02991.16 AET39696.1 - 1.1e-47 160.5 0.1 1.2e-47 160.3 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 AET39696.1 - 1.3e-07 31.9 0.0 1.7e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 tRNA-synt_1 PF00133.22 AET39698.1 - 2.3e-235 782.5 0.1 9.7e-235 780.4 0.1 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AET39698.1 - 9.5e-27 93.8 0.8 3.3e-26 92.1 0.3 2.1 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 AET39698.1 - 4.4e-15 55.3 1.1 4.6e-05 22.3 0.2 3.5 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 AET39698.1 - 9.2e-05 21.9 0.0 0.0013 18.2 0.0 2.6 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain Intron_maturas2 PF01348.21 AET39698.1 - 0.092 12.7 0.0 0.36 10.8 0.0 2.0 1 0 0 1 1 1 0 Type II intron maturase HSP70 PF00012.20 AET39699.1 - 1.3e-259 862.5 8.8 1.5e-259 862.3 8.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AET39699.1 - 2.7e-17 62.6 0.0 3.2e-16 59.0 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 AET39699.1 - 0.00026 20.8 0.0 0.00092 19.0 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 AET39699.1 - 0.023 13.7 0.4 0.66 8.9 0.1 2.4 2 1 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain BcrAD_BadFG PF01869.20 AET39699.1 - 0.038 13.5 0.0 4.3 6.7 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Hydantoinase_A PF01968.18 AET39699.1 - 0.083 12.1 0.2 0.25 10.6 0.2 1.8 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase Raco_middle PF17651.1 AET39699.1 - 0.11 12.2 0.0 18 5.0 0.0 2.9 3 0 0 3 3 3 0 RACo middle region Cnd1_N PF12922.7 AET39699.1 - 0.38 10.6 3.1 0.79 9.6 3.1 1.6 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term Golgin_A5 PF09787.9 AET39699.1 - 2.3 7.6 12.1 0.71 9.3 7.3 2.0 2 0 0 2 2 2 0 Golgin subfamily A member 5 SWI-SNF_Ssr4 PF08549.10 AET39699.1 - 3.8 6.0 9.9 1.9 7.0 0.1 2.1 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1750) AAR2 PF05282.11 AET39700.1 - 7.7e-31 107.8 0.1 1e-30 107.3 0.1 1.1 1 0 0 1 1 1 1 AAR2 protein Ribosomal_S8e PF01201.22 AET39701.1 - 1.6e-57 193.5 1.7 1.9e-57 193.3 1.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e zf-CSL PF05207.13 AET39702.1 - 4.4e-21 74.4 0.6 5.9e-21 74.0 0.6 1.2 1 0 0 1 1 1 1 CSL zinc finger ADH_zinc_N_2 PF13602.6 AET39703.1 - 1e-11 46.0 0.0 2e-11 45.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 AET39703.1 - 4.3e-06 26.6 0.0 7e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain UQ_con PF00179.26 AET39704.1 - 7.2e-22 77.5 0.6 1.3e-21 76.7 0.1 1.7 1 1 1 2 2 2 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AET39704.1 - 0.015 15.0 0.0 0.045 13.4 0.0 1.7 1 1 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 AET39704.1 - 0.018 15.4 0.4 0.018 15.4 0.4 2.4 1 1 1 2 2 2 0 RWD domain DUF4337 PF14235.6 AET39704.1 - 0.081 13.0 0.9 0.13 12.4 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Pribosyltran_N PF13793.6 AET39705.1 - 1.3e-44 150.9 0.7 1.1e-42 144.6 0.1 2.3 2 1 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 AET39705.1 - 1.4e-35 123.0 1.9 3.6e-30 105.4 1.4 2.4 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 AET39705.1 - 8.9e-17 61.1 0.7 1.5e-15 57.1 0.4 2.3 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AET39705.1 - 0.024 14.1 0.1 0.041 13.3 0.1 1.4 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase UCH PF00443.29 AET39706.1 - 5.8e-60 202.9 0.0 1.2e-59 201.9 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AET39706.1 - 4.7e-21 75.7 12.0 4.8e-19 69.1 12.0 2.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase L1R_F9L PF02442.17 AET39706.1 - 0.96 9.3 7.9 2.3 8.0 0.3 3.0 3 0 0 3 3 3 0 Lipid membrane protein of large eukaryotic DNA viruses Fungal_trans PF04082.18 AET39707.1 - 4.4e-18 65.3 3.5 8.6e-18 64.3 3.5 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET39707.1 - 5e-08 32.9 10.6 8.2e-08 32.3 10.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AhpC-TSA PF00578.21 AET39708.1 - 1.4e-30 105.8 0.0 1.9e-30 105.3 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.9 AET39708.1 - 7.9e-15 54.4 0.1 1.4e-14 53.7 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.10 AET39708.1 - 1.9e-10 40.6 0.0 2.8e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 Redoxin Kinesin PF00225.23 AET39709.1 - 8.8e-108 360.2 3.1 8.8e-108 360.2 3.1 2.7 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 AET39709.1 - 1.7e-26 92.9 0.4 1.7e-26 92.9 0.4 3.7 4 0 0 4 4 4 2 Microtubule binding FliD_N PF02465.18 AET39709.1 - 0.019 15.7 16.9 5.3 7.8 1.3 5.5 4 0 0 4 4 4 0 Flagellar hook-associated protein 2 N-terminus DUF371 PF04027.13 AET39709.1 - 0.038 13.9 1.4 0.21 11.6 0.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF371) NPV_P10 PF05531.12 AET39709.1 - 1.3 9.6 13.9 9.5 6.8 3.2 5.8 4 2 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Sel1 PF08238.12 AET39710.1 - 1.8e-45 152.4 12.6 8.6e-07 29.4 0.7 7.5 7 0 0 7 7 7 7 Sel1 repeat Rad51 PF08423.11 AET39711.1 - 7.7e-128 425.1 0.0 1.3e-127 424.4 0.0 1.3 2 0 0 2 2 2 1 Rad51 RecA PF00154.21 AET39711.1 - 1.1e-11 44.8 0.0 1.5e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 AET39711.1 - 6.7e-10 38.9 0.0 1.3e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 AET39711.1 - 5.8e-09 36.4 0.0 1.3e-08 35.3 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain ATPase PF06745.13 AET39711.1 - 8.5e-05 22.0 0.0 0.00022 20.6 0.0 1.7 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 AET39711.1 - 0.0031 16.9 0.1 0.015 14.7 0.0 2.0 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain HHH PF00633.23 AET39711.1 - 0.051 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif AAA_24 PF13479.6 AET39711.1 - 0.054 13.2 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AET39711.1 - 0.14 12.5 0.1 0.44 10.8 0.1 1.8 1 1 0 1 1 1 0 AAA domain Sec7 PF01369.20 AET39712.1 - 3.3e-13 49.7 0.6 7.4e-13 48.6 0.6 1.5 1 0 0 1 1 1 1 Sec7 domain AnfO_nitrog PF09582.10 AET39712.1 - 0.03 13.7 0.5 0.095 12.0 0.1 2.0 2 0 0 2 2 2 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) DUF2206 PF09971.9 AET39712.1 - 0.15 10.8 1.9 0.84 8.3 0.2 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2206) Proteasome PF00227.26 AET39713.1 - 1.1e-36 126.1 0.0 1.3e-36 125.9 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Cmc1 PF08583.10 AET39714.1 - 1.4e-18 66.7 9.1 1.9e-18 66.2 9.1 1.4 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.13 AET39714.1 - 0.014 15.1 3.4 0.02 14.6 3.4 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF1088 PF06469.11 AET39714.1 - 0.081 12.6 3.0 0.055 13.2 1.3 1.5 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1088) CX9C PF16860.5 AET39714.1 - 0.12 12.4 3.4 1.8 8.7 0.2 2.4 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, SLATT_5 PF18160.1 AET39714.1 - 1.6 8.0 5.5 2.1 7.6 5.5 1.1 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 YgaB PF14182.6 AET39714.1 - 5.3 7.5 9.4 28 5.2 9.4 2.0 1 1 0 1 1 1 0 YgaB-like protein RICTOR_N PF14664.6 AET39715.1 - 1.6e-94 317.0 19.3 4.5e-94 315.5 16.3 2.7 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.6 AET39715.1 - 1.4e-29 101.9 10.5 1.1e-28 99.1 0.0 5.9 7 0 0 7 7 7 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 AET39715.1 - 3.9e-28 97.5 2.1 2.1e-26 91.9 0.0 4.2 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.6 AET39715.1 - 2.3e-24 85.9 0.1 2.3e-24 85.9 0.1 4.3 5 1 0 5 5 5 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEAT PF02985.22 AET39715.1 - 5.8e-05 23.0 0.0 2 8.9 0.0 4.3 4 0 0 4 4 2 2 HEAT repeat HEAT_2 PF13646.6 AET39715.1 - 6.1e-05 23.3 0.0 0.015 15.6 0.0 3.9 4 0 0 4 4 4 1 HEAT repeats Cnd1 PF12717.7 AET39715.1 - 0.0035 17.4 1.1 0.0035 17.4 1.1 4.4 6 0 0 6 6 6 2 non-SMC mitotic condensation complex subunit 1 TAF6_C PF07571.13 AET39715.1 - 0.012 15.9 0.4 0.95 9.8 0.0 3.2 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain Vac14_Fab1_bd PF12755.7 AET39715.1 - 0.021 15.4 0.0 1.6 9.4 0.1 3.1 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region Repressor_Mnt PF11423.8 AET39715.1 - 0.98 9.2 3.0 3.4 7.5 3.0 1.9 1 0 0 1 1 1 0 Regulatory protein Mnt MitMem_reg PF13012.6 AET39715.1 - 1.2 9.5 8.0 3.8 8.0 0.2 4.1 5 0 0 5 5 3 0 Maintenance of mitochondrial structure and function IES5 PF17335.2 AET39716.1 - 1.3e-40 138.2 6.8 1.6e-40 138.0 6.8 1.1 1 0 0 1 1 1 1 Ino80 complex subunit 5 MAP65_ASE1 PF03999.12 AET39716.1 - 0.0024 16.7 4.5 0.0027 16.5 4.5 1.1 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) PEPcase PF00311.17 AET39716.1 - 0.04 12.0 1.1 0.042 11.9 1.1 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Rx_N PF18052.1 AET39716.1 - 0.071 13.4 2.4 0.23 11.8 2.3 1.9 1 1 0 1 1 1 0 Rx N-terminal domain HALZ PF02183.18 AET39716.1 - 0.13 12.6 0.4 0.13 12.6 0.4 2.3 2 0 0 2 2 2 0 Homeobox associated leucine zipper Meth_synt_2 PF01717.18 AET39717.1 - 8.6e-149 495.2 0.0 1.1e-142 475.1 0.0 2.8 3 0 0 3 3 3 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 AET39717.1 - 1.5e-123 412.3 0.0 1.8e-116 389.1 0.0 2.7 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain SEP PF08059.13 AET39718.1 - 2.9e-22 79.0 2.2 3.7e-22 78.7 0.1 2.3 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 AET39718.1 - 1e-13 51.3 0.0 1.9e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 AET39718.1 - 2.8e-12 46.3 0.5 6.2e-12 45.1 0.5 1.6 1 0 0 1 1 1 1 UBA-like domain PTH2 PF01981.16 AET39719.1 - 7e-46 155.3 0.0 9.8e-46 154.9 0.0 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Chorismate_bind PF00425.18 AET39720.1 - 1.2e-92 310.2 0.0 1.7e-92 309.6 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 AET39720.1 - 2.2e-23 83.0 0.0 3e-22 79.4 0.0 2.4 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region PP2C PF00481.21 AET39721.1 - 1.4e-78 264.1 0.0 1.9e-78 263.7 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C DUF3873 PF12989.7 AET39721.1 - 0.018 15.4 2.0 0.041 14.2 1.0 2.1 1 1 1 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3873) TatD_DNase PF01026.21 AET39722.1 - 2.1e-37 128.9 0.0 6.2e-37 127.3 0.0 1.6 1 1 0 1 1 1 1 TatD related DNase Myb_DNA-binding PF00249.31 AET39723.1 - 6.9e-12 45.4 3.7 9.8e-11 41.7 0.3 2.5 2 1 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AET39723.1 - 2.5e-10 40.5 2.5 7e-09 35.8 0.7 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain MOZ_SAS PF01853.18 AET39724.1 - 6.6e-74 247.4 0.2 1.1e-73 246.7 0.2 1.4 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 AET39724.1 - 1.1e-17 63.3 7.6 1.1e-17 63.3 7.6 1.9 2 0 0 2 2 2 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 AET39724.1 - 0.00066 20.1 0.0 0.0015 18.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 AET39724.1 - 0.019 15.2 0.0 0.055 13.7 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family RRM_1 PF00076.22 AET39725.1 - 2.9e-06 27.0 0.1 6.9e-06 25.8 0.1 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SelP_N PF04592.14 AET39725.1 - 0.063 12.7 17.1 0.15 11.4 17.1 1.6 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF3915 PF13054.6 AET39725.1 - 0.081 12.9 0.2 0.25 11.3 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Zip PF02535.22 AET39725.1 - 2.9 7.0 6.9 0.37 10.0 2.4 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter DAG_kinase_N PF14513.6 AET39725.1 - 9.7 6.4 13.0 0.54 10.4 2.6 2.8 3 0 0 3 3 3 0 Diacylglycerol kinase N-terminus Sec61_beta PF03911.16 AET39726.1 - 6.6e-18 64.5 0.8 8.3e-18 64.1 0.8 1.1 1 0 0 1 1 1 1 Sec61beta family DUF2897 PF11446.8 AET39726.1 - 4.8 7.1 5.6 6.5 6.7 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2897) tRNA-synt_2b PF00587.25 AET39727.1 - 2.3e-30 105.9 0.0 3.2e-30 105.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 AET39727.1 - 0.026 14.7 0.0 0.057 13.6 0.0 1.5 1 0 0 1 1 1 0 Anticodon binding domain PALP PF00291.25 AET39728.1 - 4.6e-75 252.8 0.2 6e-75 252.4 0.2 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 AET39728.1 - 3.8e-36 122.7 0.1 1.5e-23 82.4 0.0 2.5 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase GARS_N PF02844.15 AET39728.1 - 0.068 14.0 0.9 0.45 11.3 0.9 2.3 1 1 0 1 1 1 0 Phosphoribosylglycinamide synthetase, N domain MMR1 PF08505.10 AET39729.1 - 8.7e-10 39.3 8.7 8.7e-10 39.3 8.7 3.0 2 2 0 2 2 2 1 Mitochondrial Myo2 receptor-related protein Peroxin-13_N PF04088.13 AET39730.1 - 7.5e-48 162.5 0.3 1.1e-47 162.0 0.3 1.2 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_1 PF00018.28 AET39730.1 - 2.1e-10 40.0 0.1 5e-10 38.8 0.0 1.7 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 AET39730.1 - 1.8e-08 34.0 0.0 4.5e-08 32.7 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 AET39730.1 - 5.2e-07 29.4 0.0 9.1e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 AET39730.1 - 0.00051 20.3 0.1 0.00084 19.6 0.1 1.3 1 0 0 1 1 1 1 Bacterial SH3 domain Keratin_2_head PF16208.5 AET39730.1 - 0.023 14.8 24.8 0.046 13.9 24.8 1.5 1 0 0 1 1 1 0 Keratin type II head eIF3_subunit PF08597.10 AET39731.1 - 2.4e-45 155.4 27.5 8.4e-44 150.3 27.5 2.0 1 1 0 1 1 1 1 Translation initiation factor eIF3 subunit DUF3602 PF12223.8 AET39732.1 - 3.8e-20 72.3 9.1 2.1e-10 41.0 0.1 3.1 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) GTP1_OBG PF01018.22 AET39732.1 - 3.2 7.3 8.3 1.4 8.4 0.1 2.9 2 1 0 3 3 3 0 GTP1/OBG GATase_2 PF00310.21 AET39733.1 - 2.2e-168 560.3 0.0 3.2e-168 559.8 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 AET39733.1 - 4.4e-154 513.1 0.0 3e-153 510.3 0.0 2.2 2 0 0 2 2 2 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 AET39733.1 - 1.6e-113 378.8 0.0 4.6e-110 367.5 0.0 2.4 2 0 0 2 2 2 2 Glutamate synthase central domain GXGXG PF01493.19 AET39733.1 - 6.6e-70 234.6 1.6 1.3e-69 233.6 1.6 1.6 1 0 0 1 1 1 1 GXGXG motif Fer4_20 PF14691.6 AET39733.1 - 9.5e-23 80.1 0.0 1.8e-22 79.2 0.0 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.14 AET39733.1 - 1e-19 70.9 0.3 1.2e-18 67.3 0.3 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AET39733.1 - 1.2e-09 38.5 1.5 9e-08 32.6 0.1 3.5 3 1 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AET39733.1 - 3.8e-09 36.6 0.0 1.1e-08 35.1 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 AET39733.1 - 8.4e-06 25.3 0.0 1.6e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 AET39733.1 - 2.7e-05 23.6 3.7 0.0037 16.6 0.0 3.5 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 AET39733.1 - 3.2e-05 22.8 1.5 3.4e-05 22.7 0.1 1.8 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 AET39733.1 - 6.2e-05 22.7 0.2 0.00034 20.3 0.1 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 AET39733.1 - 0.00016 20.9 0.0 0.0003 20.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 AET39733.1 - 0.00027 20.3 0.0 0.00064 19.1 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 AET39733.1 - 0.00042 19.8 0.0 0.00094 18.6 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 AET39733.1 - 0.0014 17.9 0.0 0.0038 16.5 0.0 1.6 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.22 AET39733.1 - 0.0062 15.7 0.3 0.045 12.8 0.0 2.3 2 0 0 2 2 2 1 Glucose inhibited division protein A FMN_dh PF01070.18 AET39733.1 - 0.04 12.9 0.2 0.22 10.5 0.7 2.0 2 0 0 2 2 2 0 FMN-dependent dehydrogenase AlaDh_PNT_C PF01262.21 AET39733.1 - 0.051 12.9 0.1 4.1 6.6 0.0 2.5 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain GATase_6 PF13522.6 AET39733.1 - 0.064 13.4 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 Glutamine amidotransferase domain NAD_binding_9 PF13454.6 AET39733.1 - 0.067 13.2 0.3 0.31 11.0 0.0 2.3 2 0 0 2 2 1 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 AET39733.1 - 0.071 12.2 0.1 0.13 11.3 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_7 PF13241.6 AET39733.1 - 0.11 12.9 1.4 6.5 7.3 0.0 2.8 2 0 0 2 2 2 0 Putative NAD(P)-binding AdoHcyase_NAD PF00670.21 AET39733.1 - 0.4 10.7 5.2 12 6.0 0.8 3.3 2 1 1 3 3 3 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain TIP120 PF08623.10 AET39733.1 - 0.57 9.9 2.7 0.36 10.6 0.5 1.7 2 0 0 2 2 1 0 TATA-binding protein interacting (TIP20) MADF_DNA_bdg PF10545.9 AET39733.1 - 5.5 7.4 6.5 0.78 10.1 0.6 2.3 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like PRELI PF04707.14 AET39734.1 - 2.1e-45 154.4 0.1 2.4e-45 154.2 0.1 1.0 1 0 0 1 1 1 1 PRELI-like family Ribosomal_S6 PF01250.17 AET39734.1 - 0.094 13.0 0.2 0.46 10.8 0.1 2.0 2 1 0 2 2 2 0 Ribosomal protein S6 NMT_C PF02799.15 AET39736.1 - 2.8e-78 262.2 0.1 2.8e-78 262.2 0.1 1.5 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 AET39736.1 - 5.5e-75 250.6 0.0 1.1e-74 249.6 0.0 1.5 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 AET39736.1 - 0.00038 20.5 0.0 0.0019 18.3 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 AET39736.1 - 0.0012 19.1 0.0 0.0051 17.0 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family WD40 PF00400.32 AET39737.1 - 1.3e-09 38.5 9.6 0.00086 20.1 0.3 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat Nup160 PF11715.8 AET39737.1 - 0.00037 19.3 3.9 0.0004 19.2 1.4 1.9 2 0 0 2 2 2 1 Nucleoporin Nup120/160 WD40_like PF17005.5 AET39737.1 - 0.012 15.0 0.2 0.027 13.8 0.2 1.7 1 1 0 1 1 1 0 WD40-like domain Frankia_peptide PF14407.6 AET39737.1 - 0.026 14.5 1.1 0.062 13.3 1.1 1.6 1 0 0 1 1 1 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. Nop PF01798.18 AET39739.1 - 4.7e-84 281.4 0.1 4.7e-84 281.4 0.1 2.1 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 AET39739.1 - 3.7e-20 72.1 0.1 3.7e-20 72.1 0.1 2.6 2 1 0 2 2 2 1 NOP5NT (NUC127) domain RR_TM4-6 PF06459.12 AET39739.1 - 0.52 10.1 24.1 0.78 9.5 24.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MCM_bind PF09739.9 AET39739.1 - 1.7 7.0 17.7 2.2 6.6 17.7 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor GAGA_bind PF06217.12 AET39739.1 - 2.4 8.4 19.7 3.7 7.8 19.7 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family RNA_polI_A34 PF08208.11 AET39739.1 - 2.5 8.2 45.3 4.2 7.4 45.3 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF1943 PF09172.11 AET39739.1 - 4.7 6.4 13.5 9.9 5.3 13.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) POC1 PF10450.9 AET39740.1 - 1.2e-37 129.4 0.3 1.3e-37 129.3 0.3 1.0 1 0 0 1 1 1 1 POC1 chaperone DUF3284 PF11687.8 AET39740.1 - 0.074 12.9 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3284) Prefoldin_2 PF01920.20 AET39741.1 - 2.8e-24 85.1 13.9 3.4e-24 84.8 13.9 1.0 1 0 0 1 1 1 1 Prefoldin subunit Rh5 PF18515.1 AET39741.1 - 0.0013 18.1 0.8 0.0015 17.9 0.8 1.2 1 0 0 1 1 1 1 Rh5 coiled-coil domain DUF1192 PF06698.11 AET39741.1 - 0.005 16.9 0.8 0.083 13.0 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1192) Prefoldin PF02996.17 AET39741.1 - 0.026 14.4 8.8 3.2 7.7 8.8 2.2 1 1 0 1 1 1 0 Prefoldin subunit DUF4671 PF15710.5 AET39741.1 - 0.027 13.3 0.2 0.03 13.2 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4671) Bcr-Abl_Oligo PF09036.10 AET39741.1 - 0.056 13.5 0.4 0.056 13.5 0.4 2.1 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain NBP1 PF08537.10 AET39741.1 - 0.14 11.5 5.5 0.17 11.3 5.5 1.0 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 HalX PF08663.10 AET39741.1 - 0.26 11.6 6.9 0.68 10.3 2.4 2.3 2 0 0 2 2 2 0 HalX domain DUF4200 PF13863.6 AET39741.1 - 0.28 11.6 13.7 0.47 10.9 4.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) FliJ PF02050.16 AET39741.1 - 0.34 11.1 12.9 0.59 10.4 0.5 2.1 2 0 0 2 2 2 0 Flagellar FliJ protein DUF641 PF04859.12 AET39741.1 - 0.45 10.9 7.3 4.6 7.6 7.3 2.0 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) HSCB_C PF07743.13 AET39741.1 - 0.79 10.2 6.9 3.9 8.0 5.5 2.3 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain Spc24 PF08286.11 AET39741.1 - 0.83 9.9 12.5 1.4 9.2 4.3 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 JIP_LZII PF16471.5 AET39741.1 - 0.88 9.8 11.5 0.67 10.2 0.8 3.1 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II OmpH PF03938.14 AET39741.1 - 1.1 9.6 12.2 2.5 8.4 12.2 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) ATG16 PF08614.11 AET39741.1 - 2.4 8.3 13.0 37 4.5 13.0 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) MRPL52 PF18699.1 AET39741.1 - 3.1 8.0 10.3 0.45 10.7 0.8 2.3 2 1 0 2 2 2 0 Mitoribosomal protein mL52 FlaC_arch PF05377.11 AET39741.1 - 3.4 8.1 7.9 7.7 7.0 0.2 2.7 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) ZapB PF06005.12 AET39741.1 - 5.3 7.6 18.5 0.72 10.3 10.2 2.2 1 1 1 2 2 2 0 Cell division protein ZapB Ly49 PF08391.10 AET39741.1 - 6.5 7.1 7.8 5.4 7.4 0.6 2.1 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region COQ9 PF08511.11 AET39742.1 - 2.2e-23 81.8 0.1 4.2e-23 80.9 0.1 1.5 1 0 0 1 1 1 1 COQ9 ADH_N PF08240.12 AET39743.1 - 7.3e-24 83.8 2.8 7.3e-24 83.8 2.8 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AET39743.1 - 1.8e-19 70.0 1.2 2.5e-19 69.5 0.1 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Sacchrp_dh_NADP PF03435.18 AET39743.1 - 0.0016 18.7 0.1 0.0043 17.3 0.0 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_C PF01262.21 AET39743.1 - 0.0051 16.1 0.4 0.0087 15.4 0.4 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 AET39743.1 - 0.013 15.0 0.1 0.023 14.2 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 AET39743.1 - 0.029 14.6 0.0 0.066 13.5 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain 2-Hacid_dh_C PF02826.19 AET39743.1 - 0.034 13.5 0.1 0.059 12.7 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 AET39743.1 - 0.093 13.2 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF4722 PF15849.5 AET39743.1 - 0.17 11.6 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4722) AAA_18 PF13238.6 AET39744.1 - 3.1e-33 115.1 0.6 5e-33 114.4 0.1 1.6 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 AET39744.1 - 9.6e-08 32.5 0.0 2.5e-07 31.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 AET39744.1 - 7.5e-05 23.0 0.0 0.00021 21.6 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AET39744.1 - 0.00021 21.5 0.0 0.00045 20.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AET39744.1 - 0.00054 20.4 0.0 0.00082 19.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 AET39744.1 - 0.001 19.3 0.0 0.52 10.5 0.0 2.3 1 1 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 AET39744.1 - 0.001 19.5 0.0 0.0027 18.1 0.0 1.7 1 0 0 1 1 1 1 RNA helicase dNK PF01712.19 AET39744.1 - 0.0011 18.8 0.0 1.5 8.7 0.0 2.3 2 0 0 2 2 2 2 Deoxynucleoside kinase AAA PF00004.29 AET39744.1 - 0.0013 19.2 0.0 0.0032 17.9 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 AET39744.1 - 0.0063 16.4 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 NTPase Thymidylate_kin PF02223.17 AET39744.1 - 0.0067 16.1 0.0 1.8 8.2 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase Zeta_toxin PF06414.12 AET39744.1 - 0.0084 15.4 0.0 0.016 14.5 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin KTI12 PF08433.10 AET39744.1 - 0.01 15.3 0.0 0.026 14.0 0.0 1.6 2 0 0 2 2 2 0 Chromatin associated protein KTI12 ADK PF00406.22 AET39744.1 - 0.013 15.6 0.0 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 Adenylate kinase AAA_14 PF13173.6 AET39744.1 - 0.016 15.2 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 AET39744.1 - 0.017 14.8 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase T2SSE PF00437.20 AET39744.1 - 0.029 13.4 0.0 0.065 12.3 0.0 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_5 PF07728.14 AET39744.1 - 0.029 14.4 0.0 0.045 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 AET39744.1 - 0.03 14.7 0.0 0.064 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 AET39744.1 - 0.075 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain NOT2_3_5 PF04153.18 AET39745.1 - 1.8e-30 105.7 0.3 2.3e-30 105.3 0.3 1.1 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family zf-Mss51 PF13824.6 AET39746.1 - 2.2e-17 62.9 0.4 5.7e-17 61.6 0.4 1.7 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 DUF1713 PF08213.11 AET39747.1 - 1.4e-12 47.3 23.2 2.4e-12 46.6 23.2 1.4 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) Casc1 PF12366.8 AET39747.1 - 0.02 14.4 0.6 0.022 14.3 0.6 1.1 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 Heme_oxygenase PF01126.20 AET39748.1 - 2.3e-13 50.4 0.1 6.5e-13 48.9 0.1 1.8 1 1 0 1 1 1 1 Heme oxygenase ENTH PF01417.20 AET39749.1 - 2.6e-43 147.0 0.0 5.2e-43 146.1 0.0 1.5 1 0 0 1 1 1 1 ENTH domain AAA_23 PF13476.6 AET39749.1 - 0.016 15.7 5.6 0.016 15.7 5.6 2.4 2 0 0 2 2 2 0 AAA domain tRNA-synt_1g PF09334.11 AET39750.1 - 3.3e-88 296.1 0.0 4.3e-88 295.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 AET39750.1 - 8.1e-25 87.1 0.0 7.8e-10 37.6 0.0 3.6 3 1 1 4 4 4 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 AET39750.1 - 8.2e-09 35.2 0.0 5e-05 22.8 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 AET39750.1 - 0.0035 16.3 0.0 0.0072 15.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (K) Anticodon_1 PF08264.13 AET39750.1 - 0.0045 17.0 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA Hira PF07569.11 AET39750.1 - 0.11 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 TUP1-like enhancer of split DNA_pol_E_B PF04042.16 AET39751.1 - 1.2e-37 129.3 0.0 1.8e-37 128.8 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 AET39751.1 - 7e-37 126.4 0.2 1.2e-36 125.7 0.2 1.4 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain MAJIN PF15077.6 AET39752.1 - 1.8 8.3 8.1 2.1 8.1 8.1 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein HSP20 PF00011.21 AET39754.1 - 1.8e-19 69.8 0.0 2.2e-19 69.5 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 AET39754.1 - 0.00082 18.9 0.0 0.0013 18.2 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Peptidase_M1 PF01433.20 AET39755.1 - 9.4e-88 293.4 1.9 9.4e-88 293.4 1.9 1.7 2 0 0 2 2 2 1 Peptidase family M1 domain ERAP1_C PF11838.8 AET39755.1 - 1e-79 268.4 1.0 8.4e-78 262.1 0.4 2.4 2 0 0 2 2 2 2 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 AET39755.1 - 3.5e-54 183.8 2.0 4.8e-54 183.4 0.5 1.9 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF5011 PF16403.5 AET39755.1 - 0.16 12.1 0.2 9.8 6.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5011) RNase_H2-Ydr279 PF09468.10 AET39757.1 - 2e-19 70.3 0.1 7.6e-19 68.4 0.1 1.9 1 1 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 AET39757.1 - 7.3e-13 48.6 0.2 1.3e-12 47.8 0.2 1.4 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain Dcc1 PF09724.9 AET39757.1 - 0.03 13.6 0.0 0.048 13.0 0.0 1.3 1 0 0 1 1 1 0 Sister chromatid cohesion protein Dcc1 RNase_PH PF01138.21 AET39758.1 - 6.9e-20 71.9 0.0 1.7e-19 70.7 0.0 1.6 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AET39758.1 - 2.1e-18 66.1 0.1 6.1e-18 64.6 0.0 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 TIG PF01833.24 AET39758.1 - 0.0069 16.4 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 IPT/TIG domain HAD_2 PF13419.6 AET39759.1 - 1.9e-15 57.4 0.0 4.9e-15 56.1 0.0 1.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AET39759.1 - 1.9e-10 41.4 0.3 3.7e-08 33.9 0.3 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase CDC45 PF02724.14 AET39759.1 - 0.86 7.8 9.5 0.32 9.2 6.8 1.7 2 0 0 2 2 2 0 CDC45-like protein RRN3 PF05327.11 AET39759.1 - 5.5 5.4 14.9 7.5 5.0 14.9 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 NOA36 PF06524.12 AET39759.1 - 9.4 5.5 18.7 15 4.8 18.7 1.3 1 0 0 1 1 1 0 NOA36 protein DUF155 PF02582.14 AET39760.1 - 6.5e-45 153.4 0.4 1e-44 152.8 0.4 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 FAD_binding_1 PF00667.20 AET39761.1 - 2.5e-72 243.1 0.0 3.9e-72 242.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 AET39761.1 - 5.3e-31 107.8 0.4 1.1e-30 106.8 0.4 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 AET39761.1 - 5.9e-21 75.2 0.0 1.5e-20 73.9 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Spore_IV_A PF09547.10 AET39761.1 - 0.001 18.2 0.0 0.0019 17.2 0.0 1.4 1 0 0 1 1 1 1 Stage IV sporulation protein A (spore_IV_A) Flavodoxin_5 PF12724.7 AET39761.1 - 0.048 13.9 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 Flavodoxin domain MAGE PF01454.19 AET39762.1 - 1e-38 133.2 0.1 1.2e-38 132.9 0.1 1.1 1 0 0 1 1 1 1 MAGE family Metallophos PF00149.28 AET39763.1 - 3.5e-10 40.7 6.1 3.5e-09 37.5 6.1 2.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Ribosomal_S18 PF01084.20 AET39765.1 - 0.096 12.9 0.2 9.9 6.5 0.0 2.7 2 0 0 2 2 2 0 Ribosomal protein S18 LRR_4 PF12799.7 AET39766.1 - 0.0017 18.7 19.3 0.7 10.4 1.1 6.5 4 2 2 6 6 6 3 Leucine Rich repeats (2 copies) L_biotic_typeA PF04604.13 AET39766.1 - 0.017 15.0 0.1 0.045 13.6 0.1 1.7 1 0 0 1 1 1 0 Type-A lantibiotic HNF-1_N PF04814.13 AET39766.1 - 0.033 14.8 5.6 0.065 13.9 5.6 1.4 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Mersacidin PF16934.5 AET39766.1 - 0.11 12.3 0.6 13 5.7 0.1 2.6 2 0 0 2 2 2 0 Two-component Enterococcus faecalis cytolysin (EFC) BChl_A PF02327.17 AET39766.1 - 0.19 10.5 0.0 0.33 9.7 0.0 1.3 1 0 0 1 1 1 0 Bacteriochlorophyll A protein LRR_6 PF13516.6 AET39766.1 - 0.34 11.1 0.0 0.34 11.1 0.0 6.2 8 0 0 8 8 8 0 Leucine Rich repeat Atg31 PF09795.9 AET39767.1 - 4.9e-24 85.1 5.4 2.2e-23 83.0 5.4 1.8 1 1 0 1 1 1 1 Autophagy-related protein 31 DEAD PF00270.29 AET39768.1 - 2.5e-43 147.9 2.7 2.5e-43 147.9 2.7 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET39768.1 - 5.7e-33 113.6 0.0 1e-30 106.3 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 AET39768.1 - 1.2e-05 25.7 0.5 0.00048 20.5 0.6 2.3 1 1 1 2 2 2 1 AAA domain ResIII PF04851.15 AET39768.1 - 1.3e-05 25.3 0.1 2.4e-05 24.4 0.1 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 AET39768.1 - 8.8e-05 22.3 0.2 0.00015 21.5 0.2 1.3 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 AET39768.1 - 0.0036 17.2 0.0 0.009 15.9 0.0 1.6 1 0 0 1 1 1 1 Helicase AAA_22 PF13401.6 AET39768.1 - 0.025 14.8 1.3 0.13 12.5 1.3 2.1 1 1 0 1 1 1 0 AAA domain SWI2_SNF2 PF18766.1 AET39768.1 - 0.096 12.3 0.1 0.096 12.3 0.1 1.6 2 0 0 2 2 2 0 SWI2/SNF2 ATPase UvrD-helicase PF00580.21 AET39768.1 - 0.46 9.9 2.4 0.74 9.3 2.4 1.7 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain PRK PF00485.18 AET39769.1 - 3.5e-13 49.7 0.0 4.9e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AA_permease PF00324.21 AET39771.1 - 9.9e-105 350.9 41.1 1.2e-104 350.6 41.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AET39771.1 - 3.2e-36 125.1 40.6 4e-36 124.8 40.6 1.1 1 0 0 1 1 1 1 Amino acid permease Bac_surface_Ag PF01103.23 AET39772.1 - 1.7e-24 86.9 2.3 2.2e-24 86.5 2.3 1.1 1 0 0 1 1 1 1 Surface antigen FHA PF00498.26 AET39773.1 - 4e-05 23.9 0.4 0.00037 20.8 0.0 2.5 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 AET39773.1 - 0.00017 21.9 0.0 0.00071 19.9 0.0 2.1 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain BRCT PF00533.26 AET39773.1 - 0.0055 17.1 0.1 0.47 10.9 0.0 2.8 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain FHA_2 PF17913.1 AET39773.1 - 0.013 15.7 0.1 0.04 14.1 0.1 1.8 1 0 0 1 1 1 0 FHA domain NIBRIN_BRCT_II PF16508.5 AET39773.1 - 0.048 14.0 0.1 0.77 10.1 0.0 2.5 2 0 0 2 2 2 0 Second BRCT domain on Nijmegen syndrome breakage protein Kei1 PF08552.11 AET39774.1 - 8e-41 140.0 4.0 1.3e-40 139.3 4.0 1.3 1 1 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 RIO1 PF01163.22 AET39775.1 - 1.8e-68 229.9 2.6 1.8e-68 229.9 2.6 2.2 2 0 0 2 2 2 1 RIO1 family CDC45 PF02724.14 AET39775.1 - 1.2 7.3 21.6 2 6.6 21.6 1.2 1 0 0 1 1 1 0 CDC45-like protein TLD PF07534.16 AET39776.1 - 5.6e-28 97.9 0.3 3.7e-26 92.0 0.2 2.6 1 1 1 2 2 2 2 TLD Efg1 PF10153.9 AET39777.1 - 7.9e-32 110.0 10.1 7.9e-32 110.0 10.1 2.1 2 0 0 2 2 2 1 rRNA-processing protein Efg1 SF3A2 PF16835.5 AET39777.1 - 0.064 13.6 0.1 0.16 12.3 0.0 1.7 1 1 0 1 1 1 0 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) RNA_pol_3_Rpc31 PF11705.8 AET39777.1 - 0.13 12.4 10.5 0.26 11.5 10.5 1.6 1 1 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 E7 PF00527.18 AET39777.1 - 2.3 8.5 5.9 3.9 7.7 1.9 2.9 3 0 0 3 3 3 0 E7 protein, Early protein Sec63 PF02889.16 AET39778.1 - 7.3e-119 395.6 1.5 3.9e-78 262.2 0.1 2.5 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 AET39778.1 - 1.4e-49 168.3 1.2 4.1e-25 88.6 0.6 3.9 4 0 0 4 4 4 2 DEAD/DEAH box helicase ResIII PF04851.15 AET39778.1 - 2.3e-29 102.6 0.2 7.6e-14 52.1 0.0 2.9 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 AET39778.1 - 7.8e-20 71.3 0.7 5.5e-09 36.4 0.0 4.1 3 2 0 3 3 3 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 AET39778.1 - 6.8e-07 29.6 0.9 0.042 14.1 0.1 4.2 3 2 0 3 3 3 2 AAA domain AAA PF00004.29 AET39778.1 - 3.8e-05 24.1 0.2 0.48 10.8 0.0 3.7 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 AET39778.1 - 0.00023 21.5 0.2 0.03 14.6 0.2 2.8 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 AET39778.1 - 0.00066 19.5 0.1 3.9 7.2 0.0 4.3 4 0 0 4 4 4 1 IstB-like ATP binding protein PhoH PF02562.16 AET39778.1 - 0.00073 19.1 0.0 0.065 12.7 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein T2SSE PF00437.20 AET39778.1 - 0.0015 17.6 0.0 2.2 7.3 0.0 2.7 3 0 0 3 3 3 2 Type II/IV secretion system protein SAS-6_N PF16531.5 AET39778.1 - 0.037 14.6 2.9 8.7 7.0 0.2 4.1 4 0 0 4 4 4 0 Centriolar protein SAS N-terminal Helicase_PWI PF18149.1 AET39778.1 - 0.037 14.2 0.1 0.14 12.4 0.1 1.9 1 0 0 1 1 1 0 N-terminal helicase PWI domain AAA_7 PF12775.7 AET39778.1 - 0.08 12.4 0.3 12 5.4 0.0 3.5 5 0 0 5 5 5 0 P-loop containing dynein motor region UvrD-helicase PF00580.21 AET39778.1 - 0.55 9.7 2.3 4.4 6.7 0.0 3.3 4 0 0 4 4 4 0 UvrD/REP helicase N-terminal domain TniB PF05621.11 AET39778.1 - 0.63 9.4 2.9 16 4.8 0.3 3.4 2 1 1 3 3 3 0 Bacterial TniB protein Dynamitin PF04912.14 AET39779.1 - 9.8e-31 107.4 21.4 4.8e-24 85.4 6.7 2.1 1 1 0 2 2 2 2 Dynamitin Jnk-SapK_ap_N PF09744.9 AET39779.1 - 0.00081 19.6 4.0 0.00081 19.6 4.0 3.3 3 1 1 4 4 4 1 JNK_SAPK-associated protein-1 HrpB7 PF09486.10 AET39779.1 - 0.029 14.7 1.6 0.085 13.3 0.0 2.4 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) Baculo_PEP_C PF04513.12 AET39779.1 - 0.14 12.2 5.2 0.3 11.1 0.3 3.2 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1993 PF09351.10 AET39779.1 - 0.2 11.8 3.9 0.3 11.2 0.4 2.9 2 2 0 2 2 2 0 Domain of unknown function (DUF1993) DHC PF09626.10 AET39779.1 - 0.43 11.5 6.8 2.6 9.0 0.1 2.7 2 1 0 3 3 3 0 Dihaem cytochrome c CHASE3 PF05227.13 AET39779.1 - 0.97 9.3 10.8 1.2 9.0 0.2 3.2 2 1 0 3 3 3 0 CHASE3 domain Laminin_II PF06009.12 AET39779.1 - 1.3 9.1 14.9 0.22 11.5 1.6 3.7 3 1 1 4 4 4 0 Laminin Domain II Occludin_ELL PF07303.13 AET39779.1 - 1.6 9.5 16.9 0.17 12.6 4.1 3.7 3 1 0 3 3 3 0 Occludin homology domain DUF4795 PF16043.5 AET39779.1 - 1.6 8.2 20.1 0.086 12.4 5.9 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4795) DASH_Duo1 PF08651.10 AET39779.1 - 1.9 8.3 14.9 0.041 13.7 1.5 4.1 5 0 0 5 5 5 0 DASH complex subunit Duo1 BAR_3 PF16746.5 AET39779.1 - 2 8.1 17.1 0.034 13.9 4.4 2.8 2 1 0 2 2 2 0 BAR domain of APPL family TPR_MLP1_2 PF07926.12 AET39779.1 - 2.5 8.2 18.9 0.031 14.3 5.5 3.1 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF745 PF05335.13 AET39779.1 - 2.6 7.7 5.5 1.4 8.6 0.4 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF745) DUF1664 PF07889.12 AET39779.1 - 3.2 7.8 15.5 0.66 10.0 3.1 4.1 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) U1snRNP70_N PF12220.8 AET39779.1 - 3.2 8.5 10.4 4.6 8.0 0.1 3.1 2 2 1 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal FlxA PF14282.6 AET39779.1 - 3.2 7.8 14.5 0.67 10.0 7.1 2.7 2 0 0 2 2 2 0 FlxA-like protein Exonuc_VII_L PF02601.15 AET39779.1 - 6.6 6.2 15.7 7.6e+02 -0.6 15.7 2.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit Amidase PF01425.21 AET39780.1 - 6.7e-124 414.3 0.0 7.7e-124 414.1 0.0 1.0 1 0 0 1 1 1 1 Amidase AAA PF00004.29 AET39781.1 - 3.8e-48 163.2 0.0 7.5e-42 142.9 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AET39781.1 - 2.3e-10 40.1 0.0 6.7e-10 38.6 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain Sigma54_activ_2 PF14532.6 AET39781.1 - 6.5e-08 32.8 0.0 0.00064 19.9 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain IstB_IS21 PF01695.17 AET39781.1 - 9.7e-06 25.4 0.0 6.3e-05 22.8 0.0 2.2 3 0 0 3 3 2 1 IstB-like ATP binding protein AAA_2 PF07724.14 AET39781.1 - 2e-05 24.8 0.0 6.6e-05 23.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 AET39781.1 - 0.00015 22.2 0.0 0.00083 19.8 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 AET39781.1 - 0.00019 21.4 0.1 0.0015 18.5 0.0 2.6 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) ResIII PF04851.15 AET39781.1 - 0.004 17.2 0.0 0.016 15.2 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Sigma54_activat PF00158.26 AET39781.1 - 0.0046 16.7 0.0 1.4 8.6 0.0 3.1 2 1 0 2 2 2 1 Sigma-54 interaction domain ABC_tran PF00005.27 AET39781.1 - 0.0089 16.5 0.3 0.15 12.6 0.0 3.2 4 0 0 4 4 3 1 ABC transporter PhoH PF02562.16 AET39781.1 - 0.0092 15.5 0.1 0.082 12.3 0.0 2.1 2 0 0 2 2 2 1 PhoH-like protein TIP49 PF06068.13 AET39781.1 - 0.011 15.0 0.0 0.023 13.9 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain Bromodomain PF00439.25 AET39781.1 - 0.031 14.3 0.1 0.13 12.3 0.0 2.1 2 0 0 2 2 1 0 Bromodomain AAA_14 PF13173.6 AET39781.1 - 0.036 14.1 0.0 0.14 12.2 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 AET39781.1 - 0.039 14.1 0.0 0.11 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 AET39781.1 - 0.04 13.4 0.0 0.29 10.6 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 AET39781.1 - 0.041 13.3 0.1 0.19 11.1 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 AET39781.1 - 0.042 14.4 0.0 1.2 9.7 0.0 3.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 AET39781.1 - 0.044 13.4 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AET39781.1 - 0.051 13.9 1.1 0.73 10.1 0.2 3.1 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 AET39781.1 - 0.056 13.8 0.0 0.16 12.4 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 AET39781.1 - 0.084 12.7 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 AET39781.1 - 0.11 12.3 0.0 0.34 10.6 0.0 1.7 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 AET39781.1 - 0.73 9.6 0.0 0.73 9.6 0.0 3.2 4 0 0 4 4 3 0 AAA domain Got1 PF04178.12 AET39782.1 - 1.9e-14 54.1 17.4 6.8e-14 52.3 16.9 1.8 1 1 1 2 2 2 2 Got1/Sft2-like family DUF2157 PF09925.9 AET39782.1 - 2 8.2 24.3 2 8.2 3.2 3.6 1 1 2 3 3 3 0 Predicted membrane protein (DUF2157) SdpI PF13630.6 AET39782.1 - 6.1 7.0 8.6 11 6.2 1.1 2.4 2 0 0 2 2 2 0 SdpI/YhfL protein family DnaJ_CXXCXGXG PF00684.19 AET39783.1 - 3.2e-05 24.2 7.1 0.013 15.8 0.6 2.5 2 0 0 2 2 2 2 DnaJ central domain zinc-ribbons_6 PF07191.12 AET39783.1 - 0.016 15.2 3.7 0.16 12.0 0.8 2.4 2 0 0 2 2 2 0 zinc-ribbons Zn_Tnp_IS1595 PF12760.7 AET39783.1 - 0.34 10.9 8.5 2.3 8.2 5.0 2.6 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Cytochrom_c3_2 PF14537.6 AET39783.1 - 0.92 10.0 6.2 6.3 7.3 0.0 3.1 2 1 0 2 2 2 0 Cytochrome c3 GTP_cyclohydroI PF01227.22 AET39784.1 - 3.2e-75 251.5 0.5 3.8e-75 251.2 0.5 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 AET39784.1 - 0.0001 22.4 0.0 0.00027 21.0 0.0 1.7 1 0 0 1 1 1 1 QueF-like protein OmpH PF03938.14 AET39784.1 - 0.019 15.3 0.8 2.1 8.7 0.1 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Pkinase PF00069.25 AET39785.1 - 4e-52 177.2 0.2 2.3e-42 145.2 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AET39785.1 - 1e-23 83.9 0.8 1.4e-19 70.4 0.0 2.6 2 1 1 3 3 3 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 AET39785.1 - 0.00015 20.7 0.0 0.00049 19.0 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 AET39785.1 - 0.008 15.5 0.1 0.046 13.0 0.1 2.1 1 1 0 1 1 1 1 Kinase-like SRP1_TIP1 PF00660.17 AET39786.1 - 1.6e-09 37.7 0.0 2.7e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Seripauperin and TIP1 family Trypan_PARP PF05887.11 AET39786.1 - 1.2e-05 25.3 6.6 2e-05 24.5 6.6 1.4 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Glycophorin_A PF01102.18 AET39786.1 - 0.029 14.6 0.4 0.055 13.7 0.1 1.7 2 1 0 2 2 2 0 Glycophorin A PRIMA1 PF16101.5 AET39786.1 - 0.031 14.3 2.6 0.046 13.8 2.6 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 NESP55 PF06390.12 AET39786.1 - 0.12 11.9 7.4 0.18 11.4 7.4 1.3 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) MSA-2c PF12238.8 AET39786.1 - 0.15 12.0 6.4 0.19 11.7 6.4 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c Pheromone PF08015.11 AET39786.1 - 0.3 12.2 2.7 1.1 10.3 2.7 2.1 1 1 0 1 1 1 0 Fungal mating-type pheromone DUF4366 PF14283.6 AET39786.1 - 1.5 8.9 3.8 1.7 8.7 2.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) SPATA3 PF15662.5 AET39786.1 - 8.7 6.9 8.4 13 6.3 8.4 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated protein 3 family DEAD PF00270.29 AET39787.1 - 4.4e-46 156.8 1.5 5.4e-46 156.6 0.1 1.9 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET39787.1 - 2.1e-24 86.0 0.0 1.6e-23 83.2 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 AET39787.1 - 7.1e-18 64.6 0.2 1.3e-17 63.8 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 AET39787.1 - 1.7e-06 28.2 0.1 3.1e-06 27.3 0.1 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 AET39787.1 - 0.00018 20.8 0.1 0.00058 19.1 0.0 1.8 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase SecA_DEAD PF07517.14 AET39787.1 - 0.0037 16.6 0.0 0.012 14.9 0.0 1.6 1 1 0 1 1 1 1 SecA DEAD-like domain AAA_30 PF13604.6 AET39787.1 - 0.071 12.8 0.0 0.81 9.4 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AET39787.1 - 0.19 12.0 2.3 0.59 10.4 1.2 2.5 2 1 0 2 2 2 0 AAA domain tRNA-synt_1g PF09334.11 AET39788.1 - 1.9e-155 517.4 0.0 2.6e-155 517.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) MetRS-N PF09635.10 AET39788.1 - 2.7e-40 137.7 0.1 6e-40 136.6 0.1 1.6 1 0 0 1 1 1 1 MetRS-N binding domain tRNA-synt_1 PF00133.22 AET39788.1 - 2.1e-10 39.5 0.6 0.00018 19.9 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Mpt_N PF09176.11 AET39788.1 - 0.069 13.3 0.0 16 5.7 0.0 2.9 3 0 0 3 3 3 0 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal Anticodon_1 PF08264.13 AET39788.1 - 0.1 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA Kdo PF06293.14 AET39789.1 - 6.1e-09 35.5 0.0 1.2e-08 34.6 0.0 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AET39789.1 - 1.2e-05 25.4 0.0 0.0002 21.3 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 AET39789.1 - 0.00015 21.3 0.0 0.00019 20.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 AET39789.1 - 0.00041 20.0 0.0 0.00058 19.5 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.17 AET39789.1 - 0.0024 17.2 0.0 0.0032 16.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EcKinase PF02958.20 AET39789.1 - 0.0055 16.1 0.5 0.011 15.1 0.2 1.6 2 1 0 2 2 2 1 Ecdysteroid kinase Choline_kinase PF01633.20 AET39789.1 - 0.041 13.5 0.1 0.061 12.9 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF1679 PF07914.11 AET39789.1 - 0.052 12.4 0.1 0.067 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Aminotran_4 PF01063.19 AET39790.1 - 2e-16 60.5 0.1 4.7e-16 59.3 0.1 1.5 1 1 0 1 1 1 1 Amino-transferase class IV TetR_C_8 PF14278.6 AET39790.1 - 0.055 13.6 0.0 0.16 12.1 0.0 1.8 2 0 0 2 2 2 0 Transcriptional regulator C-terminal region NAD_binding_6 PF08030.12 AET39791.1 - 5e-21 75.4 0.0 8.5e-21 74.7 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 AET39791.1 - 4e-19 69.0 18.1 1.2e-18 67.4 18.1 1.9 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 AET39791.1 - 4.8e-18 65.2 0.0 1e-17 64.2 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Med24_N PF11277.8 AET39791.1 - 0.066 11.3 0.1 0.092 10.8 0.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal Candida_ALS_N PF11766.8 AET39792.1 - 1.4e-65 221.0 6.1 1.4e-65 221.0 6.1 2.4 3 0 0 3 3 3 1 Cell-wall agglutinin N-terminal ligand-sugar binding Big_8 PF17961.1 AET39792.1 - 0.00037 20.6 1.5 0.00085 19.4 0.0 2.4 2 0 0 2 2 2 1 Bacterial Ig domain Mito_carr PF00153.27 AET39793.1 - 1.1e-50 169.5 4.0 2.8e-18 65.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein SPC12 PF06645.13 AET39795.1 - 5.8e-22 77.6 0.4 6.7e-22 77.4 0.4 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) Tetraspanin PF00335.20 AET39795.1 - 0.0014 18.3 0.3 0.0016 18.2 0.3 1.0 1 0 0 1 1 1 1 Tetraspanin family Biotin_lipoyl PF00364.22 AET39796.1 - 1.9e-17 62.9 2.4 3.6e-17 61.9 0.6 2.2 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.17 AET39796.1 - 8.4e-06 26.0 0.0 2.2e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 e3 binding domain ATP-sulfurylase PF01747.17 AET39797.1 - 9e-86 286.7 0.0 1.2e-85 286.3 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 AET39797.1 - 1.6e-51 174.1 0.0 2.9e-51 173.3 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain Memo PF01875.17 AET39798.1 - 2.5e-80 269.5 0.0 3e-80 269.3 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Acyl-CoA_dh_C PF12806.7 AET39798.1 - 0.21 11.7 0.0 0.36 11.0 0.0 1.3 1 0 0 1 1 1 0 Acetyl-CoA dehydrogenase C-terminal like EIF_2_alpha PF07541.12 AET39799.1 - 1e-39 135.2 0.9 2e-39 134.3 0.3 1.8 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 AET39799.1 - 1.9e-15 56.9 2.1 1.9e-15 56.9 2.1 1.7 2 0 0 2 2 2 1 S1 RNA binding domain AA_permease PF00324.21 AET39800.1 - 1.1e-132 443.0 38.4 1.4e-132 442.7 38.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AET39800.1 - 4.8e-31 108.0 42.2 6.1e-31 107.7 42.2 1.1 1 0 0 1 1 1 1 Amino acid permease Pet100 PF09803.9 AET39800.1 - 0.13 12.8 0.2 0.28 11.7 0.2 1.4 1 0 0 1 1 1 0 Pet100 NUC153 PF08159.12 AET39801.1 - 4.5e-14 51.9 4.1 4.5e-14 51.9 4.1 3.9 4 0 0 4 4 4 2 NUC153 domain DUF2406 PF10295.9 AET39802.1 - 1.2e-28 99.5 0.3 2.5e-28 98.5 0.3 1.6 1 0 0 1 1 1 1 Uncharacterised protein (DUF2406) Aminotran_1_2 PF00155.21 AET39803.1 - 4.1e-61 207.2 0.0 5.4e-61 206.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Fungal_trans_2 PF11951.8 AET39804.1 - 1.9e-13 50.0 2.1 1.1e-11 44.2 2.1 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET39804.1 - 4.3e-07 29.9 11.5 1e-06 28.7 11.5 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Alb1 PF09135.11 AET39805.1 - 2.5e-24 86.2 9.9 4.2e-24 85.4 9.9 1.4 1 0 0 1 1 1 1 Alb1 AA_permease PF00324.21 AET39806.1 - 0.12 11.0 0.0 0.14 10.7 0.0 1.1 1 0 0 1 1 1 0 Amino acid permease Aldedh PF00171.22 AET39807.1 - 3.9e-180 599.3 1.2 4.4e-180 599.1 1.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LRR_4 PF12799.7 AET39808.1 - 8.6e-16 57.8 46.3 4.7e-06 26.8 1.9 7.9 4 3 2 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AET39808.1 - 5.5e-08 32.4 34.5 2.6e-05 23.9 2.4 6.1 3 1 4 7 7 7 5 Leucine rich repeat LRR_9 PF14580.6 AET39808.1 - 6e-05 22.6 12.9 0.0025 17.3 0.1 4.2 3 1 1 4 4 4 2 Leucine-rich repeat LRR_6 PF13516.6 AET39808.1 - 0.00036 20.3 29.9 2.7 8.3 0.0 9.1 10 0 0 10 10 10 4 Leucine Rich repeat Vps39_1 PF10366.9 AET39809.1 - 0.73 10.1 5.7 2.6 8.3 4.6 2.3 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 Kelch_5 PF13854.6 AET39810.1 - 5.6e-10 39.0 6.5 0.17 11.9 0.0 6.5 7 0 0 7 7 7 4 Kelch motif Kelch_3 PF13415.6 AET39810.1 - 5.7e-10 39.2 0.0 0.0004 20.6 0.1 5.0 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.6 AET39810.1 - 1.3e-07 31.6 7.6 0.081 13.2 0.2 6.0 7 0 0 7 7 7 3 Kelch motif Kelch_4 PF13418.6 AET39810.1 - 4.2e-07 29.9 1.5 0.00051 20.0 0.2 4.2 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 AET39810.1 - 9.1e-07 28.6 2.8 0.02 14.8 0.1 5.0 6 0 0 6 6 6 2 Kelch motif Kelch_1 PF01344.25 AET39810.1 - 1.2e-06 28.0 4.1 0.011 15.3 0.5 4.2 4 0 0 4 4 4 2 Kelch motif GDI PF00996.18 AET39811.1 - 2.5e-42 144.9 0.0 7.6e-42 143.3 0.0 1.7 1 1 0 1 1 1 1 GDP dissociation inhibitor Ribosomal_L7Ae PF01248.26 AET39812.1 - 2.6e-23 81.6 0.2 3.2e-23 81.3 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF1269 PF06897.12 AET39812.1 - 0.051 13.9 0.1 0.095 13.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1269) Rad1 PF02144.16 AET39813.1 - 2.4e-70 236.7 0.7 3e-70 236.4 0.7 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Peroxin-22 PF12827.7 AET39814.1 - 4e-18 65.4 0.1 5.1e-18 65.1 0.1 1.1 1 0 0 1 1 1 1 Peroxisomal biogenesis protein family FixQ PF05545.11 AET39814.1 - 0.052 13.5 0.1 0.1 12.6 0.1 1.4 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ OPA3 PF07047.12 AET39814.1 - 0.075 12.8 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) EpuA PF11772.8 AET39814.1 - 0.12 12.1 1.6 0.3 10.8 0.0 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase subunit beta CH PF00307.31 AET39815.1 - 3.9e-18 65.6 0.0 5.6e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain TENA_THI-4 PF03070.16 AET39815.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 TENA/THI-4/PQQC family AMP-binding PF00501.28 AET39816.1 - 4.9e-90 302.1 0.0 5.9e-90 301.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AET39816.1 - 2.7e-22 79.5 0.2 1.1e-21 77.6 0.1 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 AET39816.1 - 2.1e-15 56.4 0.4 2.1e-15 56.4 0.4 1.8 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus Zn_clus PF00172.18 AET39817.1 - 1.1e-09 38.3 10.2 1.1e-09 38.3 10.2 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Wtap PF17098.5 AET39817.1 - 0.022 14.7 1.0 0.19 11.7 0.1 2.5 3 0 0 3 3 3 0 WTAP/Mum2p family Zn_clus PF00172.18 AET39818.1 - 1.6e-10 40.9 14.3 3.2e-10 39.9 14.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 AET39818.1 - 0.00045 19.3 3.0 0.024 13.7 0.1 3.1 3 1 0 3 3 3 2 Fungal specific transcription factor domain EF_assoc_1 PF08355.12 AET39819.1 - 2.9e-27 94.1 1.1 6.1e-27 93.0 1.1 1.5 1 0 0 1 1 1 1 EF hand associated EF_assoc_2 PF08356.12 AET39819.1 - 1.1e-25 89.4 0.0 4.1e-25 87.6 0.0 2.0 2 0 0 2 2 2 1 EF hand associated Ras PF00071.22 AET39819.1 - 3e-24 85.4 0.0 4.8e-11 42.5 0.0 3.0 2 1 0 2 2 2 2 Ras family Roc PF08477.13 AET39819.1 - 1.7e-15 57.3 0.0 0.00015 22.0 0.0 3.4 3 0 0 3 3 3 3 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 AET39819.1 - 2.4e-08 34.0 0.0 0.00089 19.3 0.0 3.0 2 1 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_1 PF00036.32 AET39819.1 - 1.5e-07 30.5 7.5 0.0027 17.1 1.2 3.6 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 AET39819.1 - 7.8e-07 28.5 3.9 0.0059 16.5 0.5 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 AET39819.1 - 7.9e-07 29.4 1.0 0.0075 16.7 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair Dynamin_N PF00350.23 AET39819.1 - 4.8e-06 26.7 0.0 0.015 15.3 0.0 2.5 2 0 0 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 AET39819.1 - 2.8e-05 23.7 0.0 1.9 8.0 0.0 3.3 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 AET39819.1 - 6.4e-05 23.3 0.0 0.34 11.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain EF-hand_5 PF13202.6 AET39819.1 - 0.00039 19.8 7.0 0.02 14.3 2.2 2.7 2 0 0 2 2 2 2 EF hand AAA_16 PF13191.6 AET39819.1 - 0.00093 19.6 0.0 1.7 9.0 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain NACHT PF05729.12 AET39819.1 - 0.0011 18.9 0.0 0.11 12.4 0.0 2.7 3 0 0 3 3 3 1 NACHT domain RNA_helicase PF00910.22 AET39819.1 - 0.0016 18.8 0.0 0.31 11.4 0.0 2.5 2 0 0 2 2 2 1 RNA helicase RsgA_GTPase PF03193.16 AET39819.1 - 0.0039 17.1 0.0 0.017 15.0 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase TniB PF05621.11 AET39819.1 - 0.0064 15.9 0.0 0.25 10.8 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein Septin PF00735.18 AET39819.1 - 0.0067 15.7 0.0 0.12 11.6 0.0 2.2 2 0 0 2 2 2 1 Septin AAA_7 PF12775.7 AET39819.1 - 0.0092 15.5 0.0 0.26 10.8 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_24 PF13479.6 AET39819.1 - 0.014 15.2 0.0 3.4 7.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 AET39819.1 - 0.018 15.6 0.3 2 9.0 0.0 3.3 3 2 0 3 3 2 0 AAA domain PduV-EutP PF10662.9 AET39819.1 - 0.019 14.7 0.0 19 5.0 0.0 3.4 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 AET39819.1 - 0.036 14.6 0.0 1.1 9.7 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_33 PF13671.6 AET39819.1 - 0.036 14.2 0.0 11 6.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 AET39819.1 - 0.037 13.8 0.0 2.4 7.9 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain FeoB_N PF02421.18 AET39819.1 - 0.13 11.8 0.0 17 4.9 0.0 2.7 2 1 0 2 2 2 0 Ferrous iron transport protein B EF-hand_10 PF14788.6 AET39819.1 - 0.43 10.5 1.6 2.9 7.8 0.1 2.7 2 0 0 2 2 2 0 EF hand Proteasome PF00227.26 AET39820.1 - 6.9e-52 175.7 0.0 8.4e-52 175.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AET39820.1 - 6e-12 45.0 0.0 6e-12 45.0 0.0 2.4 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature NOA36 PF06524.12 AET39820.1 - 5.7 6.2 8.5 7.8 5.7 8.5 1.2 1 0 0 1 1 1 0 NOA36 protein Mto2_bdg PF12808.7 AET39821.1 - 0.0011 19.2 7.5 0.0011 19.2 7.5 4.0 3 1 0 3 3 3 1 Micro-tubular organiser Mto1 C-term Mto2-binding region eIF2A PF08662.11 AET39822.1 - 4.8e-29 101.6 0.3 4.4e-25 88.7 0.5 4.2 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 AET39822.1 - 6.5e-09 35.5 0.2 1.9e-08 34.0 0.1 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lac_bphage_repr PF06543.12 AET39822.1 - 0.064 13.2 0.4 0.064 13.2 0.4 2.1 2 0 0 2 2 2 0 Lactococcus bacteriophage repressor BolA PF01722.18 AET39823.1 - 2.6e-12 46.8 0.0 8e-12 45.3 0.0 1.7 1 1 0 1 1 1 1 BolA-like protein BolA PF01722.18 AET39824.1 - 3.2e-26 91.4 0.4 4.5e-26 90.9 0.4 1.2 1 0 0 1 1 1 1 BolA-like protein PDEase_I PF00233.19 AET39825.1 - 1.4e-54 185.3 0.2 2.2e-54 184.7 0.2 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 AET39825.1 - 0.095 12.9 0.0 0.2 11.9 0.0 1.7 1 0 0 1 1 1 0 HD domain SAM_2 PF07647.17 AET39826.1 - 1.3e-06 28.4 0.1 3.2e-06 27.2 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 AET39826.1 - 2.7e-05 24.5 0.3 0.00015 22.2 0.1 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DUF3453 PF11935.8 AET39827.1 - 2e-50 171.6 0.1 4e-50 170.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) GGDEF_2 PF17853.1 AET39827.1 - 0.067 13.4 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 GGDEF-like domain NuiA PF07924.11 AET39827.1 - 0.093 13.1 0.0 0.29 11.5 0.0 1.9 1 0 0 1 1 1 0 Nuclease A inhibitor-like protein Histone PF00125.24 AET39828.1 - 6.1e-26 91.3 0.0 7e-26 91.1 0.0 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AET39828.1 - 1.7e-22 79.5 2.1 2.8e-22 78.8 2.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAFII28 PF04719.14 AET39828.1 - 0.0052 16.8 0.1 0.0069 16.5 0.1 1.2 1 0 0 1 1 1 1 hTAFII28-like protein conserved region CENP-X PF09415.10 AET39828.1 - 0.011 16.0 0.3 0.021 15.1 0.3 1.4 1 0 0 1 1 1 0 CENP-S associating Centromere protein X DUF3791 PF12668.7 AET39828.1 - 0.032 14.3 0.0 0.059 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3791) ISP3_C PF18045.1 AET39828.1 - 0.042 13.7 0.2 1.4 8.8 0.0 2.1 1 1 1 2 2 2 0 ISP3 C-terminal TAF PF02969.17 AET39828.1 - 0.095 12.9 0.2 0.17 12.1 0.2 1.4 1 1 0 1 1 1 0 TATA box binding protein associated factor (TAF) PX PF00787.24 AET39829.1 - 1.7e-21 76.3 0.1 2.5e-21 75.7 0.1 1.3 1 0 0 1 1 1 1 PX domain COPIIcoated_ERV PF07970.12 AET39830.1 - 1.3e-78 263.8 0.9 1.6e-78 263.5 0.9 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 AET39830.1 - 1.9e-26 92.2 0.1 3.9e-26 91.2 0.1 1.6 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) ATPase-cat_bd PF12156.8 AET39830.1 - 0.23 12.2 3.8 0.57 10.9 3.8 1.7 1 0 0 1 1 1 0 Putative metal-binding domain of cation transport ATPase CDC24 PF06395.11 AET39831.1 - 8.8e-35 118.8 1.7 1.7e-34 117.9 0.5 2.2 2 0 0 2 2 2 1 CDC24 Calponin RhoGEF PF00621.20 AET39831.1 - 1.6e-33 116.5 4.8 5e-33 114.9 4.8 1.9 1 0 0 1 1 1 1 RhoGEF domain PH_10 PF15411.6 AET39831.1 - 1e-29 103.3 0.3 3e-29 101.8 0.3 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PB1 PF00564.24 AET39831.1 - 1.6e-06 27.9 0.9 5.4e-06 26.2 0.4 2.2 2 0 0 2 2 2 1 PB1 domain PH PF00169.29 AET39831.1 - 0.0075 16.8 1.7 0.053 14.0 1.7 2.6 1 1 0 1 1 1 1 PH domain ETF_QO PF05187.13 AET39832.1 - 5.8e-45 151.7 0.4 1.1e-44 150.8 0.4 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 AET39832.1 - 5.4e-10 39.4 0.0 6.1e-05 22.8 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 AET39832.1 - 4.2e-06 26.9 0.1 9.9e-06 25.7 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 AET39832.1 - 1.1e-05 24.7 0.4 0.021 13.9 0.5 2.1 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 AET39832.1 - 7.8e-05 22.0 0.0 0.23 10.7 0.1 2.2 2 0 0 2 2 2 2 Thi4 family HI0933_like PF03486.14 AET39832.1 - 7.9e-05 21.5 0.3 0.0013 17.5 0.2 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 AET39832.1 - 0.00014 21.2 0.0 0.0057 15.9 0.0 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 AET39832.1 - 0.0029 16.9 0.4 0.01 15.1 0.4 1.8 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 AET39832.1 - 0.0094 16.5 0.8 5.1 7.7 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 AET39832.1 - 0.011 15.7 0.2 0.042 13.8 0.2 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding Fer4_7 PF12838.7 AET39832.1 - 0.021 15.4 0.5 0.051 14.2 0.5 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain Pyr_redox_3 PF13738.6 AET39832.1 - 0.03 13.6 0.2 0.053 12.8 0.2 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fer4_2 PF12797.7 AET39832.1 - 0.077 13.1 0.3 0.23 11.7 0.3 1.8 1 0 0 1 1 1 0 4Fe-4S binding domain GMC_oxred_N PF00732.19 AET39832.1 - 0.1 11.9 0.0 0.3 10.4 0.0 1.7 2 0 0 2 2 2 0 GMC oxidoreductase FAD_oxidored PF12831.7 AET39832.1 - 0.17 11.2 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 AET39832.1 - 0.26 10.1 0.4 0.71 8.6 0.1 1.8 2 0 0 2 2 2 0 Tryptophan halogenase Cupin_8 PF13621.6 AET39834.1 - 6.7e-37 127.6 0.0 5e-35 121.4 0.0 2.2 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 AET39834.1 - 0.0023 18.3 0.0 0.0046 17.4 0.0 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 AET39834.1 - 0.11 12.0 0.0 1.2 8.5 0.0 2.2 2 0 0 2 2 2 0 Cupin superfamily protein Cyto_heme_lyase PF01265.17 AET39835.1 - 1.1e-98 330.5 2.1 5.1e-98 328.3 2.1 1.8 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase TFB6 PF17110.5 AET39836.1 - 1.7e-25 89.8 0.0 1.6e-24 86.6 0.0 2.1 1 1 0 1 1 1 1 Subunit 11 of the general transcription factor TFIIH Adeno_E3_CR1 PF02440.15 AET39836.1 - 0.076 12.8 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR1 MNE1 PF13762.6 AET39837.1 - 1.9e-22 79.9 2.4 1.9e-22 79.9 2.4 2.8 3 0 0 3 3 3 1 Mitochondrial splicing apparatus component RPA43_OB PF17875.1 AET39838.1 - 1.9e-27 96.3 0.1 5.2e-27 94.9 0.1 1.8 1 0 0 1 1 1 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 AET39838.1 - 4.8e-13 49.3 0.0 9e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 LPD13 PF18825.1 AET39838.1 - 0.052 13.3 0.2 2.5 7.8 0.1 2.3 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 13 FNIP PF05725.12 AET39838.1 - 0.16 12.2 0.4 0.88 9.8 0.1 2.1 2 0 0 2 2 2 0 FNIP Repeat Fungal_trans PF04082.18 AET39839.1 - 1.2e-10 40.9 1.6 2.7e-10 39.7 1.6 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET39839.1 - 0.00014 21.9 8.6 0.00031 20.8 8.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CagX PF03524.15 AET39839.1 - 0.3 10.8 3.4 0.55 9.9 3.4 1.3 1 0 0 1 1 1 0 Conjugal transfer protein Lin-8 PF03353.15 AET39839.1 - 6.8 6.1 16.1 0.37 10.3 9.8 1.8 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist MMR_HSR1_Xtn PF16897.5 AET39840.1 - 1.1e-38 131.4 0.0 2.3e-38 130.5 0.0 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 AET39840.1 - 2.4e-22 78.7 0.0 4.5e-22 77.9 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 AET39840.1 - 4.2e-19 68.7 0.0 9.5e-19 67.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AET39840.1 - 6.8e-09 35.4 0.0 1.9e-08 34.0 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 AET39840.1 - 0.012 14.7 0.2 0.025 13.6 0.2 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 AET39840.1 - 0.022 14.8 0.4 5.8 6.9 0.3 2.4 1 1 1 2 2 2 0 Dynamin family AAA_22 PF13401.6 AET39840.1 - 0.064 13.5 0.0 11 6.3 0.0 2.7 3 0 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 AET39840.1 - 0.32 10.9 2.3 4.3 7.2 0.6 3.0 3 1 0 3 3 3 0 RsgA GTPase FRG2 PF15315.6 AET39841.1 - 0.052 13.7 0.8 0.083 13.1 0.8 1.3 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 HLH PF00010.26 AET39842.1 - 1.7e-19 69.5 0.0 2.9e-19 68.7 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Mersacidin PF16934.5 AET39842.1 - 0.091 12.5 0.2 0.18 11.6 0.2 1.5 1 0 0 1 1 1 0 Two-component Enterococcus faecalis cytolysin (EFC) Ribosomal_60s PF00428.19 AET39842.1 - 0.13 12.8 3.7 6.4 7.4 0.3 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein CDC45 PF02724.14 AET39842.1 - 0.31 9.3 8.3 0.44 8.8 8.3 1.1 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.6 AET39842.1 - 0.65 10.4 9.8 1.3 9.4 9.8 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal IMS PF00817.20 AET39843.1 - 1.4e-33 116.0 0.1 2.6e-33 115.1 0.1 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 AET39843.1 - 1.2e-12 48.5 0.0 7.1e-12 46.1 0.0 2.3 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain BRCT_2 PF16589.5 AET39843.1 - 4.1e-11 43.1 0.0 9e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 AET39843.1 - 4.8e-09 36.5 0.0 2.5e-08 34.2 0.0 2.3 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 AET39843.1 - 1.3e-06 28.2 0.0 4.9e-06 26.4 0.0 2.1 2 0 0 2 2 2 1 twin BRCT domain REV1_C PF16727.5 AET39843.1 - 0.00034 21.0 0.0 0.0017 18.7 0.0 2.1 2 0 0 2 2 2 1 DNA repair protein REV1 C-terminal domain IMS_HHH PF11798.8 AET39843.1 - 0.021 15.2 0.0 0.19 12.1 0.0 2.4 2 0 0 2 2 2 0 IMS family HHH motif HHH PF00633.23 AET39843.1 - 0.053 13.4 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif DUF1805 PF08827.11 AET39843.1 - 0.085 13.2 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) NLRC4_HD2 PF17776.1 AET39843.1 - 0.13 12.8 1.0 0.91 10.1 0.1 2.7 3 0 0 3 3 3 0 NLRC4 helical domain HD2 PK PF00224.21 AET39844.1 - 1.1e-169 563.8 0.4 1.4e-169 563.5 0.4 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 AET39844.1 - 7.9e-34 116.4 0.0 2.2e-33 115.0 0.0 1.8 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 AET39844.1 - 9.5e-06 24.9 0.1 2.9e-05 23.3 0.1 1.8 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family Mis12 PF05859.12 AET39845.1 - 4.1e-41 140.2 0.4 9.3e-41 139.0 0.4 1.5 1 0 0 1 1 1 1 Mis12 protein CorA PF01544.18 AET39845.1 - 1.3 8.3 4.1 0.63 9.3 0.6 2.2 2 1 1 3 3 3 0 CorA-like Mg2+ transporter protein SWIRM PF04433.17 AET39846.1 - 8.8e-09 35.6 0.0 1.9e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 SWIRM domain MelC1 PF06236.11 AET39846.1 - 0.0079 16.3 0.3 0.014 15.4 0.3 1.4 1 0 0 1 1 1 1 Tyrosinase co-factor MelC1 Glyco_transf_24 PF18404.1 AET39847.1 - 7.8e-30 104.2 3.3 7.8e-30 104.2 3.3 1.8 2 0 0 2 2 2 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 AET39847.1 - 8.7e-19 68.5 3.5 9.1e-16 58.6 2.8 3.5 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 AET39847.1 - 1.2e-10 41.4 0.5 4.2e-10 39.7 0.2 2.0 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 AET39847.1 - 4.1e-08 33.3 0.0 1e-07 32.0 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like domain DUF3605 PF12239.8 AET39847.1 - 0.047 14.0 0.9 0.12 12.7 0.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3605) RNase_P_Rpp14 PF01900.19 AET39848.1 - 1.1e-33 115.6 0.1 1.3e-33 115.3 0.1 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family SKIP_SNW PF02731.15 AET39849.1 - 2.7e-55 186.4 1.5 2.7e-55 186.4 1.5 1.9 2 0 0 2 2 2 1 SKIP/SNW domain DUF4640 PF15480.6 AET39849.1 - 0.39 10.4 9.8 0.55 9.9 9.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4640) CorA PF01544.18 AET39851.1 - 6.6e-09 35.5 1.4 9.2e-09 35.0 1.4 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein vATP-synt_E PF01991.18 AET39852.1 - 1.9e-58 197.1 12.8 2.3e-58 196.9 12.8 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Folliculin PF11704.8 AET39852.1 - 0.66 9.8 3.0 1.1 9.1 3.0 1.4 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DNApol_Exo PF18136.1 AET39853.1 - 1.6e-95 319.5 0.1 3.6e-95 318.3 0.1 1.6 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 AET39853.1 - 1e-53 182.8 0.0 1.9e-53 181.9 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 AET39853.1 - 7e-06 25.9 0.3 0.0012 18.6 0.6 2.5 1 1 0 2 2 2 2 3'-5' exonuclease DUF2040 PF09745.9 AET39854.1 - 6.1e-07 29.5 17.4 3.9e-06 26.9 17.4 2.2 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 55 (DUF2040) NLRC4_HD2 PF17776.1 AET39854.1 - 0.015 15.8 4.9 0.29 11.7 1.0 2.5 1 1 1 2 2 2 0 NLRC4 helical domain HD2 TERB2 PF15101.6 AET39855.1 - 0.019 15.0 13.7 0.2 11.7 11.4 2.4 2 0 0 2 2 2 0 Telomere-associated protein TERB2 TMEM51 PF15345.6 AET39855.1 - 0.031 14.1 7.2 0.081 12.8 7.2 1.7 1 0 0 1 1 1 0 Transmembrane protein 51 Band_3_cyto PF07565.13 AET39855.1 - 0.068 13.0 6.2 0.18 11.6 6.2 1.7 1 0 0 1 1 1 0 Band 3 cytoplasmic domain eIF-3_zeta PF05091.12 AET39855.1 - 0.29 10.1 13.7 1 8.3 11.3 2.4 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PepSY_TM PF03929.16 AET39855.1 - 0.95 9.1 6.5 2.8 7.5 6.5 1.8 1 0 0 1 1 1 0 PepSY-associated TM region Ureide_permease PF07168.11 AET39855.1 - 1.1 8.0 2.6 1.8 7.2 2.6 1.2 1 0 0 1 1 1 0 Ureide permease Tim54 PF11711.8 AET39855.1 - 1.1 8.0 9.4 2.6 6.8 9.4 1.6 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 AET39855.1 - 1.6 7.8 4.5 3.7 6.7 4.5 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter RuvC_III PF18541.1 AET39855.1 - 1.6 8.6 11.3 2 8.4 9.4 2.1 2 0 0 2 2 2 0 RuvC endonuclease subdomain 3 Baculo_PP31 PF05311.11 AET39855.1 - 2.1 7.8 11.1 0.61 9.5 7.8 1.7 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) EMC3_TMCO1 PF01956.16 AET39855.1 - 2.6 7.7 9.6 5.9 6.6 9.6 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Connexin PF00029.19 AET39855.1 - 3.9 7.2 7.2 8.2 6.1 7.2 1.5 1 0 0 1 1 1 0 Connexin FAM76 PF16046.5 AET39855.1 - 4.1 6.7 14.5 0.23 10.8 6.9 2.2 2 0 0 2 2 2 0 FAM76 protein EIIBC-GUT_N PF03612.14 AET39855.1 - 4.3 7.0 10.3 11 5.7 10.3 1.6 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus BRF1 PF07741.13 AET39855.1 - 4.7 7.6 13.4 0.39 11.1 6.9 2.4 2 0 0 2 2 2 0 Brf1-like TBP-binding domain YABBY PF04690.13 AET39855.1 - 5 7.7 10.5 13 6.4 9.4 2.2 2 0 0 2 2 2 0 YABBY protein DUF4407 PF14362.6 AET39855.1 - 5 6.4 7.6 11 5.3 7.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Presenilin PF01080.17 AET39855.1 - 5.9 5.6 14.7 0.3 9.8 8.2 2.0 2 0 0 2 2 2 0 Presenilin DUF4770 PF15994.5 AET39855.1 - 6.2 7.0 15.4 1.1 9.5 10.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Spt20 PF12090.8 AET39855.1 - 8.4 5.9 39.5 0.14 11.7 31.9 1.9 2 0 0 2 2 1 0 Spt20 family Synaptobrevin PF00957.21 AET39856.1 - 2.9e-31 107.1 1.5 3.3e-31 106.9 1.5 1.0 1 0 0 1 1 1 1 Synaptobrevin Prominin PF05478.11 AET39856.1 - 0.023 12.7 0.2 0.026 12.5 0.2 1.0 1 0 0 1 1 1 0 Prominin TRP PF06011.12 AET39856.1 - 0.025 13.3 0.0 0.026 13.3 0.0 1.0 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF3671 PF12420.8 AET39856.1 - 0.039 14.0 0.0 0.05 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF3619 PF12279.8 AET39856.1 - 0.11 12.8 0.1 0.13 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) Myosin_head PF00063.21 AET39857.1 - 1.3e-279 929.1 12.8 2.1e-279 928.5 12.8 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) DIL PF01843.19 AET39857.1 - 1.2e-24 86.5 1.8 1.2e-24 86.5 1.8 3.3 3 0 0 3 3 3 1 DIL domain DivIC PF04977.15 AET39857.1 - 0.00021 21.0 26.3 0.18 11.6 0.5 6.2 4 1 1 5 5 5 3 Septum formation initiator DUF3194 PF11419.8 AET39857.1 - 0.00084 19.6 1.1 0.0064 16.8 1.1 2.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3194) Tup_N PF08581.10 AET39857.1 - 0.0011 19.2 2.8 0.0011 19.2 2.8 4.4 4 0 0 4 4 4 1 Tup N-terminal Myosin_N PF02736.19 AET39857.1 - 0.0019 18.0 0.2 0.0058 16.4 0.2 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain ADIP PF11559.8 AET39857.1 - 0.0025 17.9 7.2 0.0025 17.9 7.2 3.4 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding IQ PF00612.27 AET39857.1 - 0.0036 17.0 20.3 0.4 10.6 0.1 6.2 7 0 0 7 7 6 2 IQ calmodulin-binding motif AAA_22 PF13401.6 AET39857.1 - 0.011 16.1 1.8 0.04 14.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 AET39857.1 - 0.03 14.7 0.9 0.48 10.8 0.0 2.9 2 0 0 2 2 2 0 AAA ATPase domain DUF1843 PF08898.10 AET39857.1 - 0.54 10.8 3.2 2.8 8.5 0.2 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) YabA PF06156.13 AET39857.1 - 1.6 9.4 22.9 2 9.1 1.6 4.5 3 1 0 4 4 3 0 Initiation control protein YabA ABC_tran PF00005.27 AET39857.1 - 1.7 9.2 5.7 0.8 10.2 0.0 3.1 2 1 0 2 2 2 0 ABC transporter SseC PF04888.12 AET39857.1 - 1.8 8.1 7.6 4.6 6.7 7.6 1.6 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Fib_alpha PF08702.10 AET39857.1 - 5.5 7.2 18.0 3.5 7.8 6.6 3.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family HIP1_clath_bdg PF16515.5 AET39857.1 - 6.9 7.4 26.5 0.12 13.0 7.1 4.0 3 1 1 4 4 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Hph PF13694.6 AET39858.1 - 6.7e-07 29.8 0.2 4.7e-05 23.8 0.2 2.3 1 1 0 1 1 1 1 Sec63/Sec62 complex-interacting family HrpB7 PF09486.10 AET39858.1 - 0.46 10.9 4.3 0.5 10.7 0.6 2.2 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Saw1 PF11561.8 AET39859.1 - 6e-80 268.3 0.0 6.7e-80 268.1 0.0 1.0 1 0 0 1 1 1 1 Single strand annealing-weakened 1 Aldedh PF00171.22 AET39860.1 - 4.6e-11 41.9 1.1 1.7e-07 30.2 0.2 2.2 2 0 0 2 2 2 2 Aldehyde dehydrogenase family DUF1542 PF07564.11 AET39860.1 - 0.018 15.1 2.9 1.3 9.2 1.5 2.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) PhoLip_ATPase_C PF16212.5 AET39861.1 - 3.4e-84 282.5 25.8 3.4e-84 282.5 25.8 2.9 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 AET39861.1 - 1.3e-23 82.4 7.2 3.8e-23 81.0 7.2 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 AET39861.1 - 5.5e-10 39.9 2.8 3.1e-05 24.4 0.5 3.6 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AET39861.1 - 1.9e-09 37.5 0.0 6.3e-09 35.8 0.0 1.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 AET39861.1 - 5.8e-06 25.9 1.5 7.3e-06 25.6 0.1 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 AET39861.1 - 0.002 17.9 0.8 0.02 14.6 0.8 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Ribosomal_L28e PF01778.17 AET39862.1 - 2.6e-40 137.7 2.4 2.6e-40 137.7 2.4 1.7 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 AET39862.1 - 1.2e-29 102.8 15.1 1.2e-29 102.8 15.1 2.7 2 1 1 3 3 3 1 Mak16 protein C-terminal region Ribosomal_L24e PF01246.20 AET39862.1 - 0.0029 17.8 0.3 0.0085 16.3 0.3 1.9 1 0 0 1 1 1 1 Ribosomal protein L24e BUD22 PF09073.10 AET39862.1 - 0.003 17.0 16.1 0.0036 16.7 16.1 1.1 1 0 0 1 1 1 1 BUD22 PYC_OADA PF02436.18 AET39862.1 - 0.033 13.9 2.7 0.062 13.0 2.7 1.5 1 1 0 1 1 1 0 Conserved carboxylase domain DUF789 PF05623.12 AET39862.1 - 0.76 9.4 4.8 1.2 8.7 4.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF789) Ribosomal_L24e PF01246.20 AET39864.1 - 3e-32 110.6 3.8 3e-32 110.6 3.8 2.6 3 0 0 3 3 3 1 Ribosomal protein L24e Pam16 PF03656.13 AET39865.1 - 1e-05 25.6 0.0 1.3e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Pam16 DnaJ PF00226.31 AET39865.1 - 0.0023 18.0 0.1 0.0035 17.4 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain SMC_Nse1 PF07574.13 AET39866.1 - 5.2e-50 170.0 0.6 7.5e-50 169.5 0.6 1.2 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 AET39866.1 - 2e-09 37.6 10.0 2e-09 37.6 10.0 1.8 2 0 0 2 2 2 1 RING-like domain Response_reg PF00072.24 AET39867.1 - 1.1e-19 70.7 0.0 1.9e-12 47.4 0.1 2.4 2 0 0 2 2 2 2 Response regulator receiver domain Adaptin_N PF01602.20 AET39868.1 - 1.7e-85 287.6 22.2 2.1e-85 287.3 22.2 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 AET39868.1 - 1.3e-19 70.8 3.8 1.3e-19 70.8 3.8 3.9 3 2 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 AET39868.1 - 0.012 15.7 0.9 40 4.4 0.0 4.6 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat TIP120 PF08623.10 AET39868.1 - 0.039 13.7 0.7 0.16 11.7 0.1 2.3 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) WASH-7_C PF14746.6 AET39868.1 - 0.049 13.3 1.1 0.18 11.5 0.2 2.3 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal CMS1 PF14617.6 AET39869.1 - 1.9e-15 56.9 6.8 1.4e-14 54.1 6.8 2.4 1 1 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Glyco_hydro_92 PF07971.12 AET39870.1 - 1.2e-122 410.1 2.9 1.6e-122 409.7 2.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 AET39870.1 - 1.3e-44 152.8 1.1 2.2e-44 152.1 1.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Bac_rhamnosid6H PF17389.2 AET39870.1 - 0.016 14.5 0.2 0.029 13.6 0.2 1.4 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain MFS_1 PF07690.16 AET39871.1 - 2.6e-29 102.3 18.0 2.6e-29 102.3 18.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TMEM234 PF10639.9 AET39871.1 - 1.4 9.0 5.7 3.3 7.8 0.9 2.8 3 0 0 3 3 3 0 Putative transmembrane family 234 Adaptin_N PF01602.20 AET39872.1 - 5.9e-90 302.3 12.8 6.9e-90 302.1 12.8 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 AET39872.1 - 1.6e-11 44.5 5.6 2.4e-09 37.4 0.1 4.1 3 2 3 6 6 6 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 AET39872.1 - 9.6e-08 31.7 2.6 0.048 13.9 0.1 5.6 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 AET39872.1 - 2.1e-07 31.2 0.4 0.00014 22.2 0.1 3.9 3 2 1 4 4 4 2 HEAT repeats UNC45-central PF11701.8 AET39872.1 - 0.00014 21.9 0.6 0.0056 16.7 0.1 3.0 3 0 0 3 3 3 1 Myosin-binding striated muscle assembly central HEAT_EZ PF13513.6 AET39872.1 - 0.00086 19.8 0.5 9.7 6.8 0.1 4.8 4 1 1 5 5 5 1 HEAT-like repeat Gpi16 PF04113.14 AET39873.1 - 2e-186 620.8 0.0 2.7e-186 620.4 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Elong_Iki1 PF10483.9 AET39874.1 - 8.2e-73 245.5 0.3 9.3e-73 245.3 0.3 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 CRT10 PF08728.10 AET39875.1 - 7e-176 586.5 8.2 8.3e-176 586.2 8.2 1.0 1 0 0 1 1 1 1 CRT10 Pico_P2A PF00947.19 AET39875.1 - 0.1 12.7 0.0 1.2 9.2 0.0 2.4 2 0 0 2 2 2 0 Picornavirus core protein 2A ANAPC8 PF04049.13 AET39876.1 - 7.2e-37 126.6 4.7 1.4e-36 125.6 4.7 1.5 1 0 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.28 AET39876.1 - 4.4e-25 86.4 15.3 4.3e-05 23.1 0.1 6.2 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 AET39876.1 - 4.5e-22 76.4 14.3 0.00031 20.7 0.1 6.9 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 AET39876.1 - 1.7e-20 71.4 14.2 0.00031 20.6 0.0 7.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 AET39876.1 - 3.1e-16 58.7 1.9 0.0054 17.5 0.0 5.5 4 1 1 5 5 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 AET39876.1 - 9e-13 47.7 4.5 2.4e-07 30.3 0.0 5.4 3 3 2 5 5 5 2 TPR repeat TPR_12 PF13424.6 AET39876.1 - 2e-08 34.4 10.0 0.037 14.3 1.2 5.3 2 1 4 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 AET39876.1 - 2.9e-08 34.2 3.1 1.1e-05 25.9 0.0 4.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 AET39876.1 - 3e-08 34.0 1.3 0.0028 18.1 0.3 5.2 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 AET39876.1 - 9.4e-08 31.6 1.1 0.094 12.8 0.0 4.7 3 1 1 4 4 4 2 Tetratricopeptide repeat ChAPs PF09295.10 AET39876.1 - 4.9e-07 29.1 0.1 1.7e-06 27.3 0.0 1.8 2 1 1 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_17 PF13431.6 AET39876.1 - 7.5e-07 29.1 16.0 0.0096 16.2 0.1 6.5 7 0 0 7 7 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 AET39876.1 - 1.2e-06 28.7 21.5 0.0068 16.6 1.9 5.3 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 AET39876.1 - 6.2e-06 26.7 0.8 0.00019 21.9 0.4 2.8 2 1 0 2 2 2 1 Bacterial transcriptional activator domain TPR_15 PF13429.6 AET39876.1 - 9.5e-06 25.0 1.7 0.00025 20.4 0.4 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 AET39876.1 - 0.00016 21.8 0.9 0.091 12.9 0.1 3.3 2 1 2 4 4 4 2 Tetratricopeptide repeat Sel1 PF08238.12 AET39876.1 - 0.00036 21.1 5.9 20 6.1 0.4 5.1 5 0 0 5 5 4 0 Sel1 repeat TPR_6 PF13174.6 AET39876.1 - 0.00076 20.0 10.8 5.7 7.8 0.0 7.1 7 0 0 7 7 7 1 Tetratricopeptide repeat THP2 PF09432.10 AET39877.1 - 3e-45 153.4 2.7 3e-45 153.4 2.7 1.9 2 0 0 2 2 2 1 Tho complex subunit THP2 Mod_r PF07200.13 AET39877.1 - 0.01 16.0 5.4 0.014 15.5 0.4 2.5 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Erp_C PF06780.11 AET39877.1 - 0.092 12.8 4.5 0.12 12.3 0.4 2.7 2 1 1 3 3 3 0 Erp protein C-terminus GTP1_OBG PF01018.22 AET39878.1 - 7e-37 126.4 1.7 4.8e-27 94.5 2.3 2.2 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 AET39878.1 - 6.2e-22 77.8 0.0 1.2e-21 76.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 AET39878.1 - 9.4e-13 48.0 0.0 1.8e-12 47.0 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family FeoB_N PF02421.18 AET39878.1 - 1.1e-10 41.3 0.0 3.2e-10 39.8 0.0 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 AET39878.1 - 0.0088 16.0 0.2 0.051 13.6 0.3 2.1 1 1 1 2 2 2 1 C-terminal region of MMR_HSR1 domain MeaB PF03308.16 AET39878.1 - 0.011 14.8 0.0 2.2 7.2 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Ras PF00071.22 AET39878.1 - 0.029 13.9 0.0 0.1 12.2 0.0 1.8 2 0 0 2 2 2 0 Ras family SRPRB PF09439.10 AET39878.1 - 0.037 13.5 0.0 0.14 11.5 0.0 1.9 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 AET39878.1 - 0.05 13.1 0.0 0.65 9.5 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 AET39878.1 - 0.09 12.8 0.0 2.2 8.3 0.0 2.5 1 1 1 2 2 2 0 Dynamin family RsgA_GTPase PF03193.16 AET39878.1 - 0.11 12.4 0.1 15 5.5 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase DEAD PF00270.29 AET39879.1 - 3.5e-40 137.6 0.2 4.3e-39 134.1 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET39879.1 - 2.2e-31 108.5 0.2 5.4e-31 107.2 0.1 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET39879.1 - 0.0074 16.3 0.1 0.027 14.5 0.0 2.0 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Phage_integrase PF00589.22 AET39879.1 - 0.079 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Phage integrase family NOP19 PF10863.8 AET39880.1 - 1.5e-51 174.0 9.8 1.5e-51 174.0 9.8 1.7 2 0 0 2 2 2 1 Nucleolar protein 19 PRA-CH PF01502.18 AET39880.1 - 0.18 11.7 1.1 1.9 8.4 0.1 2.3 2 0 0 2 2 2 0 Phosphoribosyl-AMP cyclohydrolase Rotamase PF00639.21 AET39880.1 - 2.3 9.3 12.1 0.23 12.4 2.2 2.9 2 1 1 3 3 3 0 PPIC-type PPIASE domain NMD3 PF04981.13 AET39881.1 - 1.9e-84 283.0 1.3 3.6e-84 282.0 1.3 1.5 1 0 0 1 1 1 1 NMD3 family HypA PF01155.19 AET39881.1 - 0.56 10.2 5.3 11 6.1 0.0 2.6 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 AET39881.1 - 1.7 8.7 7.3 84 3.3 7.3 2.7 1 1 0 1 1 1 0 Double zinc ribbon FYVE PF01363.21 AET39881.1 - 4.8 7.4 6.3 5.2 7.3 3.1 2.5 2 1 0 2 2 2 0 FYVE zinc finger Bromodomain PF00439.25 AET39882.1 - 5.8e-26 90.4 1.8 1.3e-25 89.3 1.8 1.6 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 AET39882.1 - 2.3e-09 37.5 0.1 4.4e-09 36.6 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AET39882.1 - 6.5e-06 26.1 0.0 1.3e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AET39882.1 - 0.00052 20.4 0.2 0.001 19.5 0.2 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Proteasome PF00227.26 AET39883.1 - 2.5e-54 183.6 0.1 3.2e-54 183.3 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AET39883.1 - 2.9e-12 46.0 0.0 5.3e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature GCP_N_terminal PF17681.1 AET39884.1 - 2.7e-44 152.0 0.3 4.2e-43 148.1 0.0 2.6 2 1 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 AET39884.1 - 1.2e-25 90.6 4.3 6e-25 88.4 4.3 1.9 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal Enolase_C PF00113.22 AET39885.1 - 1.3e-151 503.9 0.0 1.8e-151 503.4 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 AET39885.1 - 8.8e-59 197.4 0.4 1.6e-58 196.6 0.4 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 AET39885.1 - 1.5e-05 24.7 0.0 2.5e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 AET39885.1 - 0.051 12.7 0.7 0.12 11.6 0.2 1.9 2 1 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus Ctr PF04145.15 AET39886.1 - 3.6e-19 69.8 12.9 4.5e-12 46.8 4.5 2.1 1 1 1 2 2 2 2 Ctr copper transporter family TctB PF07331.11 AET39886.1 - 0.00087 19.6 0.0 0.00098 19.4 0.0 1.1 1 0 0 1 1 1 1 Tripartite tricarboxylate transporter TctB family DUF1286 PF06939.11 AET39886.1 - 0.87 9.9 7.1 1.3 9.3 4.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1286) DUF3899 PF13038.6 AET39886.1 - 8.7 6.9 9.7 1.7 9.2 1.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3899) FMO-like PF00743.19 AET39887.1 - 6.4e-38 130.5 0.2 5.2e-32 111.0 0.0 2.2 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 AET39887.1 - 2.3e-17 63.2 0.0 2.1e-15 56.8 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 AET39887.1 - 3.8e-16 59.2 0.0 5.5e-15 55.4 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 AET39887.1 - 3.1e-15 56.5 0.3 2.2e-12 47.2 0.0 3.5 2 2 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 AET39887.1 - 5.4e-11 42.7 0.2 5.9e-05 22.8 0.0 3.0 3 1 0 4 4 4 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 AET39887.1 - 1.4e-08 34.3 0.5 0.0002 20.7 0.1 3.1 1 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Amino_oxidase PF01593.24 AET39887.1 - 3.5e-08 33.2 0.0 0.0024 17.2 0.0 2.5 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 AET39887.1 - 5e-08 33.1 0.1 1.7e-07 31.3 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 AET39887.1 - 8.3e-06 25.2 0.1 0.00013 21.3 0.0 2.1 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 AET39887.1 - 3.9e-05 24.1 0.7 0.18 12.4 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 AET39887.1 - 6.2e-05 21.9 0.0 0.0036 16.1 0.0 2.4 3 0 0 3 3 3 1 HI0933-like protein Shikimate_DH PF01488.20 AET39887.1 - 0.0021 18.1 0.0 0.95 9.5 0.0 2.5 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 AET39887.1 - 0.015 14.7 0.0 0.11 11.9 0.0 2.0 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 AET39887.1 - 0.029 13.4 0.0 0.23 10.5 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein IlvN PF07991.12 AET39887.1 - 0.03 13.9 0.2 1.1 8.8 0.1 2.2 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain 3HCDH_N PF02737.18 AET39887.1 - 0.03 14.2 0.5 3.8 7.3 0.1 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glu_dehyd_C PF16912.5 AET39887.1 - 0.037 13.5 0.1 7.1 6.0 0.0 2.2 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus FAD_binding_3 PF01494.19 AET39887.1 - 0.058 12.6 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Latrotoxin_C PF15658.6 AET39887.1 - 0.065 13.0 0.0 0.38 10.5 0.0 2.1 1 1 1 2 2 2 0 Latrotoxin C-terminal domain TrkA_N PF02254.18 AET39887.1 - 0.085 13.1 0.1 8.8 6.6 0.0 2.4 2 0 0 2 2 2 0 TrkA-N domain Trp_halogenase PF04820.14 AET39887.1 - 0.11 11.4 1.1 9.9 4.9 0.1 2.5 3 0 0 3 3 3 0 Tryptophan halogenase GIDA PF01134.22 AET39887.1 - 0.2 10.7 0.0 13 4.7 0.0 2.9 3 0 0 3 3 3 0 Glucose inhibited division protein A Erv26 PF04148.13 AET39888.1 - 1.2e-79 266.9 4.4 1.5e-79 266.6 4.4 1.1 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 PhoR PF11808.8 AET39888.1 - 0.031 14.7 0.5 0.031 14.7 0.5 3.1 3 1 1 4 4 4 0 Phosphate regulon sensor protein PhoR DUF996 PF06195.13 AET39888.1 - 0.28 11.5 4.8 0.051 13.9 1.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF996) UbiA PF01040.18 AET39888.1 - 0.92 8.8 9.7 2.7 7.2 9.7 1.8 1 1 0 1 1 1 0 UbiA prenyltransferase family PI_PP_I PF18363.1 AET39889.1 - 3.1 8.1 7.0 1.1 9.5 2.2 2.6 3 0 0 3 3 3 0 Phosphoinositide phosphatase insertion domain 6PGD PF00393.19 AET39890.1 - 1.2e-125 418.7 0.0 1.5e-125 418.4 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 AET39890.1 - 2.9e-46 157.5 0.0 4.2e-46 157.0 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 AET39890.1 - 0.053 13.8 0.2 0.22 11.8 0.0 2.1 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Mito_carr PF00153.27 AET39891.1 - 1e-58 195.3 1.9 5e-23 80.8 0.1 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 AET39891.1 - 0.073 12.2 0.3 0.3 10.2 0.0 2.1 3 0 0 3 3 3 0 Gammaproteobacterial serine protease XPG_N PF00752.17 AET39893.1 - 6.3e-32 110.1 0.0 1.8e-31 108.6 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 AET39893.1 - 5.4e-24 84.4 0.3 2.4e-23 82.3 0.0 2.4 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 AET39893.1 - 0.0064 17.1 0.0 0.035 14.7 0.0 2.3 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold 5_3_exonuc_N PF02739.16 AET39893.1 - 0.067 13.1 0.3 0.38 10.6 0.1 2.1 2 0 0 2 2 2 0 5'-3' exonuclease, N-terminal resolvase-like domain Ribosomal_L7Ae PF01248.26 AET39894.1 - 3.6e-28 97.1 0.7 5.3e-28 96.6 0.7 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Citrate_synt PF00285.21 AET39894.1 - 0.01 14.9 0.0 0.014 14.5 0.0 1.1 1 0 0 1 1 1 0 Citrate synthase, C-terminal domain DUF3519 PF12033.8 AET39895.1 - 0.87 10.0 7.7 0.63 10.5 5.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3519) Adaptin_N PF01602.20 AET39897.1 - 5.5e-103 345.3 14.4 8e-103 344.8 14.4 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Coatamer_beta_C PF07718.12 AET39897.1 - 1.5e-52 177.2 2.2 2.3e-52 176.6 0.3 2.4 2 0 0 2 2 2 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 AET39897.1 - 3.1e-50 169.5 0.0 7.4e-50 168.2 0.0 1.7 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform HEAT_2 PF13646.6 AET39897.1 - 3e-07 30.7 2.6 1.3 9.5 0.0 4.8 1 1 3 4 4 4 3 HEAT repeats Cnd1 PF12717.7 AET39897.1 - 4.7e-06 26.7 15.1 2.7e-05 24.3 0.1 4.7 3 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 DUF5578 PF17741.1 AET39897.1 - 3.1e-05 23.5 9.1 0.025 14.0 0.9 4.0 3 1 1 4 4 4 2 Family of unknown function (DUF5578) Alpha_adaptinC2 PF02883.20 AET39897.1 - 0.0065 16.8 0.0 0.023 15.0 0.0 1.9 2 0 0 2 2 1 1 Adaptin C-terminal domain HEAT PF02985.22 AET39897.1 - 0.009 16.2 0.0 8.1 7.0 0.0 4.1 4 0 0 4 4 3 1 HEAT repeat NolV PF06635.12 AET39897.1 - 0.027 13.8 0.1 0.26 10.7 0.0 2.3 2 1 1 3 3 3 0 Nodulation protein NolV Peptidase_M99 PF17033.5 AET39897.1 - 0.086 12.3 0.0 0.26 10.7 0.0 1.7 2 0 0 2 2 2 0 Carboxypeptidase controlling helical cell shape catalytic Vac14_Fab1_bd PF12755.7 AET39897.1 - 0.097 13.3 0.1 0.42 11.2 0.1 2.1 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region AP4E_app_platf PF14807.6 AET39897.1 - 0.16 12.3 1.7 1.4 9.3 0.0 3.2 3 0 0 3 3 3 0 Adaptin AP4 complex epsilon appendage platform IZUMO PF15005.6 AET39897.1 - 0.57 10.7 4.8 1.3 9.6 0.4 3.2 3 0 0 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated Ribosomal_L5_C PF00673.21 AET39898.1 - 8.2e-26 90.0 0.0 4.4e-25 87.7 0.0 2.0 2 0 0 2 2 2 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 AET39898.1 - 5.6e-11 42.6 0.0 1.6e-10 41.2 0.0 1.8 1 0 0 1 1 1 1 Ribosomal protein L5 GLE1 PF07817.13 AET39899.1 - 8.8e-86 287.2 0.0 1.3e-85 286.6 0.0 1.3 1 0 0 1 1 1 1 GLE1-like protein Caldesmon PF02029.15 AET39899.1 - 0.37 9.5 32.3 0.49 9.1 32.3 1.1 1 0 0 1 1 1 0 Caldesmon DUF572 PF04502.13 AET39899.1 - 0.48 10.0 24.2 0.65 9.6 24.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) CDC45 PF02724.14 AET39899.1 - 0.92 7.7 13.8 1.3 7.3 13.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DDHD PF02862.17 AET39899.1 - 3.1 7.9 7.1 5.4 7.1 7.1 1.5 1 0 0 1 1 1 0 DDHD domain GAGA_bind PF06217.12 AET39899.1 - 5.8 7.1 15.4 8.3 6.6 15.4 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Flavokinase PF01687.17 AET39900.1 - 3.8e-29 101.2 0.0 4.9e-29 100.9 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase Porphobil_deam PF01379.20 AET39901.1 - 4.8e-72 241.8 0.0 6e-72 241.4 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 AET39901.1 - 3.5e-21 75.4 0.3 6e-21 74.6 0.3 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Aconitase PF00330.20 AET39902.1 - 1.8e-108 363.5 0.1 3.1e-107 359.5 0.1 2.5 2 1 0 2 2 2 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 AET39902.1 - 7.9e-28 97.4 0.0 1.4e-27 96.6 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Reticulon PF02453.17 AET39903.1 - 4.6e-36 124.2 2.8 6.2e-36 123.7 2.8 1.2 1 0 0 1 1 1 1 Reticulon DUF2547 PF10818.8 AET39903.1 - 0.019 15.9 0.1 0.05 14.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2547) Aminotran_1_2 PF00155.21 AET39904.1 - 3.7e-74 250.1 0.0 1.7e-73 247.9 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 AET39904.1 - 7e-08 31.4 0.0 1.1e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 AET39904.1 - 9.8e-05 21.5 0.0 0.00021 20.4 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 AET39904.1 - 0.0068 15.8 0.1 0.25 10.6 0.0 2.2 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 AET39904.1 - 0.045 13.0 0.2 0.096 11.9 0.2 1.5 1 1 0 1 1 1 0 Beta-eliminating lyase Preseq_ALAS PF09029.10 AET39904.1 - 0.079 13.4 0.5 0.21 12.1 0.5 1.7 1 0 0 1 1 1 0 5-aminolevulinate synthase presequence Wtap PF17098.5 AET39905.1 - 7.5e-09 35.7 14.7 2.5e-08 34.0 14.6 1.9 1 1 0 1 1 1 1 WTAP/Mum2p family Lzipper-MIP1 PF14389.6 AET39905.1 - 0.43 10.9 12.7 1.1 9.5 0.4 3.8 4 1 0 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 Noggin PF05806.12 AET39905.1 - 0.83 9.5 2.4 1.3 8.9 0.2 2.2 2 0 0 2 2 2 0 Noggin ABC_tran_CTD PF16326.5 AET39905.1 - 3.2 8.1 15.5 0.5 10.7 3.9 3.5 3 1 0 3 3 3 0 ABC transporter C-terminal domain DAHP_synth_1 PF00793.20 AET39906.1 - 9.2e-101 336.3 0.0 1.1e-100 336.1 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Cellulase PF00150.18 AET39907.1 - 2.6e-12 46.8 5.4 4.4e-12 46.0 5.4 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) PRP1_N PF06424.12 AET39908.1 - 7.7e-29 101.0 1.7 1.4e-28 100.1 0.2 2.3 2 0 0 2 2 2 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 AET39908.1 - 3.3e-25 86.6 0.1 0.02 15.7 0.0 9.9 6 4 4 10 10 10 7 Tetratricopeptide repeat TPR_19 PF14559.6 AET39908.1 - 1.6e-14 54.1 0.0 0.02 15.4 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 AET39908.1 - 3.4e-07 29.9 0.6 0.037 14.1 0.0 6.1 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 AET39908.1 - 1.6e-06 28.7 0.0 1.5 9.6 0.0 6.0 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 AET39908.1 - 7.2e-05 22.9 1.4 3.4 8.3 0.1 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 AET39908.1 - 0.0019 18.4 0.0 1.9 8.8 0.0 4.2 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 AET39908.1 - 0.002 17.4 10.7 0.46 9.6 0.0 5.9 3 2 3 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 AET39908.1 - 0.01 16.4 1.1 3.7 8.4 0.0 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 AET39908.1 - 0.019 14.6 0.0 2.2 8.0 0.0 3.6 4 0 0 4 4 4 0 TPR repeat TPR_8 PF13181.6 AET39908.1 - 0.024 14.8 3.5 5.2 7.5 0.0 5.5 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 AET39908.1 - 0.025 14.4 0.1 0.37 10.7 0.0 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat ARTD15_N PF18084.1 AET39908.1 - 0.043 14.1 0.4 2.3 8.5 0.0 3.3 2 1 1 3 3 3 0 ARTD15 N-terminal domain DUF413 PF04219.12 AET39908.1 - 0.07 13.2 0.1 0.29 11.2 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function, DUF TPR_7 PF13176.6 AET39908.1 - 0.14 12.2 0.0 2.7 8.2 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Fungal_trans_2 PF11951.8 AET39909.1 - 4.8e-23 81.6 0.7 2.4e-22 79.3 0.7 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET39909.1 - 1.3e-06 28.4 12.0 2.6e-06 27.5 12.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SGL PF08450.12 AET39910.1 - 8.9e-60 202.3 0.0 1.6e-59 201.5 0.0 1.4 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 AET39910.1 - 1.6e-09 37.8 0.0 0.012 15.8 0.0 4.0 3 1 1 4 4 4 3 Arylesterase CX9C PF16860.5 AET39911.1 - 3.8e-32 110.0 8.9 1.9e-19 69.4 0.7 2.1 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 AET39911.1 - 6e-06 26.3 10.4 0.0017 18.5 0.6 2.7 2 1 0 2 2 2 2 CHCH domain COX6B PF02297.17 AET39911.1 - 9.1e-05 22.6 6.5 0.0012 19.0 0.3 2.1 1 1 1 2 2 2 2 Cytochrome oxidase c subunit VIb UPF0203 PF05254.12 AET39911.1 - 0.00011 22.4 6.8 0.0055 16.9 1.6 2.9 1 1 2 3 3 3 2 Uncharacterised protein family (UPF0203) Cmc1 PF08583.10 AET39911.1 - 0.0096 15.9 11.4 0.11 12.5 4.1 2.3 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like ALMT PF11744.8 AET39911.1 - 0.028 13.3 0.1 0.031 13.1 0.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Pet191_N PF10203.9 AET39911.1 - 0.042 14.2 11.6 0.19 12.0 6.8 2.9 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 GCK PF07802.11 AET39911.1 - 0.26 11.8 8.7 0.14 12.6 1.7 2.3 2 1 0 2 2 2 0 GCK domain NDUF_B7 PF05676.13 AET39911.1 - 0.37 10.5 7.8 0.72 9.6 1.6 2.4 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF1752 PF08550.10 AET39912.1 - 1.4e-13 50.4 1.5 3.5e-13 49.1 1.5 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) MCD PF05292.11 AET39912.1 - 0.75 9.3 12.3 1.5 8.3 12.3 1.4 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase C-terminal domain DUF4770 PF15994.5 AET39912.1 - 8.1 6.6 24.2 35 4.6 24.2 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) LMBR1 PF04791.16 AET39912.1 - 8.1 5.2 13.3 15 4.4 13.3 1.5 1 0 0 1 1 1 0 LMBR1-like membrane protein CPSF100_C PF13299.6 AET39912.1 - 10 6.3 25.8 5.2 7.2 18.3 3.4 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Pex2_Pex12 PF04757.14 AET39913.1 - 2.5e-20 73.0 11.0 4.7e-20 72.2 11.0 1.4 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.6 AET39913.1 - 1.1 9.1 8.5 3.1 7.7 3.9 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Vps54 PF07928.12 AET39914.1 - 1.8e-05 25.2 0.3 9.2e-05 22.9 0.3 2.3 1 0 0 1 1 1 1 Vps54-like protein NOA36 PF06524.12 AET39914.1 - 5.2 6.3 10.7 14 4.9 10.7 1.6 1 0 0 1 1 1 0 NOA36 protein Menin PF05053.13 AET39914.1 - 9.3 4.5 16.4 17 3.6 16.4 1.3 1 0 0 1 1 1 0 Menin Myb_DNA-binding PF00249.31 AET39915.1 - 1.8e-19 69.7 27.3 2.2e-11 43.8 1.0 5.8 6 1 0 6 6 6 4 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AET39915.1 - 3e-19 69.0 16.4 3.1e-15 56.1 2.0 4.3 3 1 1 4 4 4 2 Myb-like DNA-binding domain DUF1376 PF07120.11 AET39915.1 - 0.034 14.4 0.2 0.12 12.7 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1376) RHH_6 PF16762.5 AET39915.1 - 0.077 13.6 4.5 3.3 8.4 0.2 3.6 3 0 0 3 3 3 0 Ribbon-helix-helix domain Myb_DNA-bind_4 PF13837.6 AET39915.1 - 0.32 11.4 11.0 0.82 10.1 1.2 4.4 3 1 1 4 4 4 0 Myb/SANT-like DNA-binding domain RskA PF10099.9 AET39915.1 - 0.87 9.9 5.7 1.5 9.1 5.7 1.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA MADF_DNA_bdg PF10545.9 AET39915.1 - 1.1 9.6 11.5 17 5.8 0.5 4.4 2 2 2 4 4 4 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Ribosomal_S17_N PF16205.5 AET39916.1 - 2.3e-32 111.2 0.7 4e-32 110.4 0.7 1.4 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 AET39916.1 - 2.1e-27 95.0 2.8 4.6e-27 93.9 2.8 1.6 1 0 0 1 1 1 1 Ribosomal protein S17 FMP23 PF17315.2 AET39917.1 - 8.5e-56 188.3 8.7 3.1e-55 186.5 8.7 1.8 1 1 0 1 1 1 1 Found in mitochondrial proteome tRNA-synt_2b PF00587.25 AET39919.1 - 1.6e-32 112.9 0.0 2.8e-32 112.1 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 AET39919.1 - 2.9e-21 75.7 10.0 2.9e-21 75.7 10.0 1.7 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain FapA PF03961.13 AET39919.1 - 0.14 10.7 6.1 0.21 10.1 6.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A PRP38 PF03371.15 AET39920.1 - 0.024 14.5 0.2 0.059 13.2 0.2 1.6 1 0 0 1 1 1 0 PRP38 family Mgm101p PF06420.12 AET39921.1 - 1.5e-84 281.7 0.0 2.1e-84 281.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 PMT PF02366.18 AET39922.1 - 2.8e-83 279.3 22.8 5e-83 278.4 22.8 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 AET39922.1 - 5.9e-60 202.3 5.1 5.9e-60 202.3 5.1 3.3 2 1 0 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 AET39922.1 - 3.5e-26 92.2 0.1 6.7e-26 91.3 0.1 1.4 1 0 0 1 1 1 1 MIR domain DUF3403 PF11883.8 AET39922.1 - 0.17 12.1 0.7 0.36 11.0 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3403) DHHA2 PF02833.14 AET39923.1 - 3e-23 82.6 0.1 5.2e-23 81.8 0.1 1.3 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 AET39923.1 - 7.8e-11 42.1 0.6 2e-10 40.8 0.1 1.9 2 0 0 2 2 2 1 DHH family HECT_2 PF09814.9 AET39924.1 - 7e-60 202.9 1.0 7.8e-60 202.7 1.0 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Ppnp PF06865.11 AET39924.1 - 0.013 15.9 0.0 0.025 15.0 0.0 1.4 1 0 0 1 1 1 0 Pyrimidine/purine nucleoside phosphorylase Homoserine_dh PF00742.19 AET39926.1 - 6.7e-54 182.4 0.0 8.5e-54 182.1 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 AET39926.1 - 5.7e-19 68.9 0.0 9.4e-19 68.2 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Nif11 PF07862.11 AET39926.1 - 0.035 14.4 0.0 8.4 6.8 0.0 3.2 3 0 0 3 3 3 0 Nif11 domain RBP_receptor PF14752.6 AET39926.1 - 0.16 10.5 0.0 0.23 10.0 0.0 1.1 1 0 0 1 1 1 0 Retinol binding protein receptor IML1 PF12257.8 AET39927.1 - 2e-102 342.2 0.0 3e-102 341.6 0.0 1.3 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 AET39927.1 - 4.6e-25 87.5 0.1 1.2e-24 86.1 0.1 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) NIR_SIR PF01077.22 AET39928.1 - 1.1e-50 171.3 0.0 5.6e-48 162.4 0.0 2.3 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain Flavodoxin_1 PF00258.25 AET39928.1 - 2.7e-27 95.7 0.0 8.1e-27 94.2 0.0 1.9 2 0 0 2 2 2 1 Flavodoxin NIR_SIR_ferr PF03460.17 AET39928.1 - 6.9e-26 89.9 0.1 1.7e-11 43.8 0.1 2.5 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain RHH_7 PF16777.5 AET39928.1 - 0.01 16.2 0.1 0.055 13.9 0.0 2.1 2 0 0 2 2 2 0 Transcriptional regulator, RHH-like, CopG Chalcone_2 PF16035.5 AET39929.1 - 1.1e-59 201.6 0.0 1.4e-59 201.4 0.0 1.1 1 0 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 AET39929.1 - 0.0032 17.6 0.3 1.1 9.4 0.2 2.2 1 1 1 2 2 2 2 Chalcone isomerase-like Tti2 PF10521.9 AET39930.1 - 3.8e-58 197.2 3.7 4.9e-58 196.9 3.7 1.2 1 0 0 1 1 1 1 Tti2 family Sybindin PF04099.12 AET39930.1 - 0.1 12.5 0.1 0.24 11.3 0.1 1.6 1 0 0 1 1 1 0 Sybindin-like family zf-Tim10_DDP PF02953.15 AET39931.1 - 3e-19 68.4 6.5 3.5e-19 68.2 6.5 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF3336 PF11815.8 AET39931.1 - 0.0086 15.8 0.5 0.0097 15.6 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) INTS5_N PF14837.6 AET39931.1 - 0.041 13.5 3.2 0.049 13.2 3.2 1.0 1 0 0 1 1 1 0 Integrator complex subunit 5 N-terminus SlyX PF04102.12 AET39932.1 - 0.097 13.3 1.2 0.19 12.4 0.0 2.0 2 0 0 2 2 2 0 SlyX RIX1 PF08167.12 AET39933.1 - 9.7e-49 165.7 3.7 9.7e-49 165.7 3.7 2.1 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis Pribosyltran PF00156.27 AET39934.1 - 7.7e-11 41.8 0.1 1.2e-10 41.2 0.1 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain SGL PF08450.12 AET39935.1 - 0.0054 16.3 0.0 0.025 14.1 0.0 2.1 1 1 1 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region IBN_N PF03810.19 AET39936.1 - 9.3e-18 63.9 0.0 1.8e-15 56.6 0.0 3.4 2 0 0 2 2 2 2 Importin-beta N-terminal domain Cse1 PF08506.10 AET39936.1 - 8.7e-05 21.5 3.2 8.7e-05 21.5 3.2 2.6 2 1 1 3 3 3 1 Cse1 ABC2_membrane_2 PF12679.7 AET39937.1 - 0.81 8.9 7.4 1.4 8.2 7.4 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein MDM31_MDM32 PF08118.11 AET39938.1 - 6e-222 738.0 5.9 4.9e-221 735.0 5.9 1.9 1 1 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins PIR PF00399.19 AET39939.1 - 1.4e-07 30.8 16.7 0.00025 20.5 3.3 2.9 2 0 0 2 2 2 2 Yeast PIR protein repeat PIR PF00399.19 AET39940.1 - 9.6e-48 158.8 92.5 9.5e-09 34.6 3.3 8.1 8 0 0 8 8 8 7 Yeast PIR protein repeat Fimbrial_PilY2 PF14481.6 AET39940.1 - 0.0056 16.3 1.2 6.3 6.5 0.1 2.9 1 1 3 4 4 4 4 Type 4 fimbrial biogenesis protein PilY2 HTH_37 PF13744.6 AET39940.1 - 0.0074 16.2 1.3 43 4.2 0.0 3.6 1 1 4 5 5 5 4 Helix-turn-helix domain DUF637 PF04830.13 AET39940.1 - 3.5 7.4 13.2 9.1 6.1 4.6 2.9 1 1 1 2 2 2 0 Possible hemagglutinin (DUF637) ATP-synt_J PF04911.12 AET39942.1 - 3.1e-28 97.1 0.6 3.4e-28 97.0 0.6 1.0 1 0 0 1 1 1 1 ATP synthase j chain CsgF PF10614.9 AET39942.1 - 0.094 12.9 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Type VIII secretion system (T8SS), CsgF protein Cys_Met_Meta_PP PF01053.20 AET39943.1 - 1.9e-23 82.7 0.0 2.2e-22 79.1 0.0 2.1 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 AET39943.1 - 0.019 14.1 0.0 0.045 12.9 0.0 1.6 1 0 0 1 1 1 0 Aminotransferase class I and II Glyco_hydro_47 PF01532.20 AET39944.1 - 2.1e-137 458.8 0.2 2.5e-137 458.5 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Ctf8 PF09696.10 AET39945.1 - 9.9e-21 74.6 0.1 1.4e-18 67.6 0.1 2.1 1 1 0 1 1 1 1 Ctf8 zinc_ribbon_10 PF10058.9 AET39946.1 - 6.4e-17 61.0 1.4 1e-16 60.3 1.4 1.3 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein LGT PF01790.18 AET39946.1 - 0.011 15.0 0.2 0.015 14.5 0.2 1.2 1 0 0 1 1 1 0 Prolipoprotein diacylglyceryl transferase Neur_chan_memb PF02932.16 AET39946.1 - 0.017 15.2 0.1 0.027 14.5 0.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DASH_Duo1 PF08651.10 AET39946.1 - 0.036 13.8 4.9 4.6 7.1 0.0 3.2 2 1 1 3 3 3 0 DASH complex subunit Duo1 GARP PF16731.5 AET39946.1 - 0.038 13.7 3.2 0.28 10.8 0.3 2.2 2 0 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma Exonuc_VII_L PF02601.15 AET39946.1 - 0.092 12.3 2.4 0.13 11.9 2.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit HemX PF04375.14 AET39946.1 - 0.1 11.9 4.3 0.14 11.4 4.3 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase HypA PF01155.19 AET39946.1 - 0.13 12.3 0.4 0.22 11.6 0.4 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CENP-Q PF13094.6 AET39946.1 - 0.24 11.6 8.6 0.42 10.8 8.6 1.6 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit zf-ribbon_3 PF13248.6 AET39946.1 - 0.27 10.7 1.7 0.45 10.0 0.2 2.0 2 0 0 2 2 2 0 zinc-ribbon domain Zn_ribbon_SprT PF17283.2 AET39946.1 - 0.35 10.8 6.0 0.74 9.8 1.1 2.3 2 0 0 2 2 2 0 SprT-like zinc ribbon domain V-SNARE PF05008.15 AET39946.1 - 1.1 9.7 11.4 0.12 12.7 5.6 2.4 3 1 0 3 3 1 0 Vesicle transport v-SNARE protein N-terminus FliD_N PF02465.18 AET39946.1 - 1.1 10.0 6.5 0.52 11.0 3.3 2.0 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Csm1_N PF18504.1 AET39946.1 - 2.7 8.4 9.1 0.6 10.5 4.2 2.2 2 0 0 2 2 2 0 Csm1 N-terminal domain SlyX PF04102.12 AET39946.1 - 4.6 7.9 12.7 4 8.1 1.1 3.6 3 1 1 4 4 4 0 SlyX Seryl_tRNA_N PF02403.22 AET39946.1 - 8.4 6.7 11.3 1.4e+02 2.8 11.3 2.3 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain NAC PF01849.18 AET39947.1 - 2.9e-20 72.0 1.1 4.4e-20 71.4 0.4 1.7 2 0 0 2 2 2 1 NAC domain TGFb_propeptide PF00688.18 AET39947.1 - 0.024 14.4 0.1 0.03 14.1 0.1 1.3 1 1 0 1 1 1 0 TGF-beta propeptide BRE1 PF08647.11 AET39947.1 - 3.4 7.8 6.4 2.9 8.0 0.1 2.9 3 1 0 3 3 3 0 BRE1 E3 ubiquitin ligase RVT_1 PF00078.27 AET39948.1 - 1.3e-28 100.1 0.0 2.7e-28 99.0 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 AET39948.1 - 4.2e-27 94.5 0.0 1.2e-26 93.0 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 AET39948.1 - 8.3e-26 89.9 0.0 2.4e-25 88.5 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 AET39948.1 - 1.4e-22 79.5 0.7 3.2e-22 78.4 0.7 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 AET39948.1 - 1.2e-13 51.2 0.0 3.5e-13 49.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 AET39948.1 - 9.5e-07 28.6 1.5 1.9e-06 27.7 1.5 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-H2C2 PF09337.10 AET39948.1 - 3.6e-05 23.9 0.5 0.00029 21.0 0.0 2.8 3 0 0 3 3 3 1 H2C2 zinc finger Peptidase_A2B PF12384.8 AET39948.1 - 0.00023 20.8 0.5 0.00062 19.4 0.1 1.9 2 0 0 2 2 2 1 Ty3 transposon peptidase gag-asp_proteas PF13975.6 AET39948.1 - 0.016 15.8 0.0 0.039 14.5 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 AET39948.1 - 0.039 14.6 0.0 0.089 13.4 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease PIR PF00399.19 AET39949.1 - 6.1e-07 28.8 3.2 2.1e-06 27.1 3.2 2.0 1 0 0 1 1 1 1 Yeast PIR protein repeat zf-RING_2 PF13639.6 AET39950.1 - 0.011 16.1 2.1 0.019 15.3 1.5 1.8 1 1 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.25 AET39950.1 - 0.014 15.3 2.4 0.035 14.0 2.4 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PH_10 PF15411.6 AET39950.1 - 0.024 14.9 0.0 0.061 13.6 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain PaREP1 PF05942.11 AET39950.1 - 0.061 13.3 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Archaeal PaREP1/PaREP8 family Tropomodulin PF03250.14 AET39950.1 - 0.1 12.7 0.0 0.3 11.1 0.0 1.8 1 0 0 1 1 1 0 Tropomodulin zf-RING_11 PF17123.5 AET39950.1 - 3.5 7.5 6.5 0.26 11.0 1.1 2.0 2 0 0 2 2 2 0 RING-like zinc finger Peptidase_S64 PF08192.11 AET39951.1 - 1e-276 920.0 0.2 1.2e-276 919.7 0.2 1.0 1 0 0 1 1 1 1 Peptidase family S64 6PF2K PF01591.18 AET39952.1 - 3.9e-80 268.3 0.0 5.5e-80 267.8 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 AET39952.1 - 2.2e-36 125.4 0.0 2.9e-36 125.0 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 AET39952.1 - 0.00082 19.6 0.0 0.0031 17.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain DUF844 PF05815.11 AET39952.1 - 0.12 11.5 0.1 0.43 9.7 0.1 1.8 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF844) Vps35 PF03635.17 AET39953.1 - 6.3e-278 924.2 23.3 7.4e-278 924.0 23.3 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Pam17 PF08566.10 AET39954.1 - 4.3e-64 215.3 0.0 6.2e-64 214.8 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 MFS_1 PF07690.16 AET39954.1 - 0.0078 15.2 0.1 0.0099 14.8 0.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily LapA_dom PF06305.11 AET39954.1 - 0.23 11.3 0.5 1.8 8.5 0.1 2.4 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain F-box-like PF12937.7 AET39955.1 - 3.1e-08 33.4 0.8 1.1e-07 31.6 0.3 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 AET39955.1 - 2.4e-06 27.3 0.2 1.3e-05 24.9 0.2 2.4 1 0 0 1 1 1 1 F-box domain Zn_clus PF00172.18 AET39956.1 - 1.4e-09 37.9 7.1 3.1e-09 36.8 7.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RNA_polI_A34 PF08208.11 AET39957.1 - 2.7e-31 109.3 17.1 3.9e-31 108.7 17.1 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 VIR_N PF15912.5 AET39957.1 - 0.98 9.0 7.8 9.4 5.7 9.4 1.7 2 0 0 2 2 2 0 Virilizer, N-terminal Presenilin PF01080.17 AET39957.1 - 1.9 7.2 4.1 1.9 7.1 4.1 1.2 1 0 0 1 1 1 0 Presenilin TFA2_Winged_2 PF18121.1 AET39958.1 - 1.1e-17 63.5 0.0 2.5e-17 62.3 0.0 1.7 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 AET39958.1 - 2.5e-13 50.1 0.1 7e-13 48.7 0.1 1.8 1 0 0 1 1 1 1 TFIIE beta subunit core domain Pfk_N PF18468.1 AET39958.1 - 0.11 12.9 0.1 0.51 10.8 0.0 2.0 2 0 0 2 2 2 0 Phosphofructokinase N-terminal domain yeast CRAL_TRIO PF00650.20 AET39961.1 - 2.4e-26 92.3 0.2 1.1e-25 90.3 0.1 1.8 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 AET39961.1 - 0.01 16.0 0.1 0.019 15.1 0.1 1.5 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 AET39961.1 - 0.09 13.0 0.7 0.23 11.7 0.3 2.0 2 0 0 2 2 2 0 CRAL/TRIO, N-terminal domain Tim17 PF02466.19 AET39963.1 - 1.4e-31 109.1 6.1 1.9e-31 108.7 6.1 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family RNA_pol_Rpb4 PF03874.16 AET39964.1 - 1.3e-35 122.3 5.3 2.4e-35 121.6 5.3 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb4 Glyco_transf_15 PF01793.16 AET39965.1 - 1.4e-113 379.5 12.0 1.6e-113 379.2 12.0 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Ribosomal_L1 PF00687.21 AET39966.1 - 1.6e-44 152.1 0.4 2e-44 151.8 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family TUDOR PF00567.24 AET39966.1 - 0.2 11.7 2.6 5.9 6.9 0.0 2.8 2 1 1 3 3 3 0 Tudor domain DEAD PF00270.29 AET39967.1 - 9.9e-47 159.0 1.0 1.4e-46 158.5 0.2 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET39967.1 - 1.2e-31 109.3 0.3 3.3e-30 104.7 0.1 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET39967.1 - 6.3e-07 29.6 0.0 1.2e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 AET39967.1 - 0.00091 19.6 0.1 0.015 15.6 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AET39967.1 - 0.0031 17.3 0.0 0.0055 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain UTP25 PF06862.12 AET39967.1 - 0.0093 14.8 0.2 2 7.1 0.0 2.2 2 0 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 AET39967.1 - 0.014 14.7 0.0 0.033 13.5 0.0 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit UvsW PF11637.8 AET39967.1 - 0.097 12.8 0.1 0.49 10.5 0.0 2.2 2 0 0 2 2 2 0 ATP-dependant DNA helicase UvsW Glyco_transf_8 PF01501.20 AET39968.1 - 4.3e-24 85.4 0.3 2.5e-23 83.0 0.3 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 8 ARL2_Bind_BART PF11527.8 AET39968.1 - 0.43 10.7 1.8 0.73 10.0 0.8 1.8 2 0 0 2 2 2 0 The ARF-like 2 binding protein BART Ribosomal_S21e PF01249.18 AET39969.1 - 6.3e-40 135.2 0.0 7.1e-40 135.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e tRNA_U5-meth_tr PF05958.11 AET39970.1 - 7.5e-22 77.8 0.1 1.3e-20 73.7 0.1 2.2 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase TRAM PF01938.20 AET39970.1 - 3.6e-10 39.7 0.0 7.1e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 TRAM domain Methyltransf_31 PF13847.6 AET39970.1 - 1.5e-07 31.4 0.1 3.6e-07 30.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 AET39970.1 - 4.2e-06 27.4 0.0 1.1e-05 26.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 AET39970.1 - 6.3e-06 25.8 0.1 1.2e-05 24.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.10 AET39970.1 - 2.5e-05 23.9 1.0 4.4e-05 23.1 0.1 1.9 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.15 AET39970.1 - 6.6e-05 22.6 0.4 0.00024 20.8 0.0 2.1 3 0 0 3 3 3 1 Conserved hypothetical protein 95 MTS PF05175.14 AET39970.1 - 0.00059 19.4 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.16 AET39970.1 - 0.0038 17.0 0.9 0.0094 15.7 0.2 2.2 3 1 0 3 3 3 1 Met-10+ like-protein Ubie_methyltran PF01209.18 AET39970.1 - 0.0039 16.6 0.0 0.0082 15.5 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 AET39970.1 - 0.018 15.7 0.0 0.079 13.6 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_4 PF02390.17 AET39970.1 - 0.047 13.2 0.1 0.17 11.3 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase PAP2 PF01569.21 AET39971.1 - 1e-17 64.2 1.1 1e-17 64.2 1.1 2.0 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 AET39971.1 - 0.0012 18.6 1.7 0.0012 18.6 1.7 2.1 2 0 0 2 2 2 1 PAP2 superfamily Mito_carr PF00153.27 AET39972.1 - 2.6e-61 203.6 2.1 2.6e-21 75.3 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein AhpC-TSA_2 PF13911.6 AET39972.1 - 0.075 13.2 0.0 0.095 12.8 0.0 1.4 1 1 0 1 1 1 0 AhpC/TSA antioxidant enzyme Solute_trans_a PF03619.16 AET39973.1 - 1.2e-71 241.4 15.6 1.4e-71 241.1 15.6 1.0 1 0 0 1 1 1 1 Organic solute transporter Ostalpha mIF3 PF14877.6 AET39974.1 - 4.2e-58 195.9 6.9 4.2e-58 195.9 6.9 1.5 2 0 0 2 2 2 1 Mitochondrial translation initiation factor CPSase_L_D2 PF02786.17 AET39975.1 - 2.1e-116 386.8 0.4 3.2e-83 278.4 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 AET39975.1 - 2.4e-49 166.4 0.0 6.5e-49 165.0 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 AET39975.1 - 1.8e-45 155.0 0.0 4.4e-45 153.8 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase class-I OTCace_N PF02729.21 AET39975.1 - 7.8e-45 152.5 0.0 2.1e-44 151.1 0.0 1.8 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 AET39975.1 - 2.7e-38 131.1 0.1 6.8e-38 129.8 0.1 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 AET39975.1 - 1.2e-26 93.7 0.0 1.3e-25 90.4 0.0 2.9 4 0 0 4 4 3 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 AET39975.1 - 1.1e-20 73.5 0.0 6.8e-20 71.1 0.0 2.5 2 0 0 2 2 2 1 MGS-like domain Dala_Dala_lig_C PF07478.13 AET39975.1 - 6.6e-18 65.0 1.4 5.9e-11 42.3 0.2 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 AET39975.1 - 1.2e-14 54.2 0.2 2.1e-07 30.7 0.1 2.6 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 AET39975.1 - 1.1e-11 44.6 0.0 1e-06 28.5 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 AET39975.1 - 4.5e-06 26.8 0.6 0.0029 17.7 0.1 2.7 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.13 AET39975.1 - 9.5e-05 22.2 0.0 0.019 14.7 0.0 2.7 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 AET39975.1 - 0.0015 18.3 0.3 0.051 13.4 0.0 3.4 5 0 0 5 5 5 1 DJ-1/PfpI family GARS_A PF01071.19 AET39975.1 - 0.0035 17.1 0.5 1 9.1 0.1 2.9 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_5 PF13549.6 AET39975.1 - 0.054 12.9 0.1 6.8 6.1 0.0 2.4 2 0 0 2 2 2 0 ATP-grasp domain TrkA_N PF02254.18 AET39975.1 - 0.071 13.4 0.1 0.48 10.7 0.1 2.5 1 0 0 1 1 1 0 TrkA-N domain NBD_C PF17042.5 AET39975.1 - 0.081 13.4 0.0 20 5.6 0.0 3.4 3 0 0 3 3 3 0 Nucleotide-binding C-terminal domain HMG_box PF00505.19 AET39976.1 - 2.6e-31 107.8 4.3 7.4e-15 55.1 0.8 2.2 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 AET39976.1 - 1.3e-22 80.2 3.4 3.1e-12 46.9 0.9 2.4 2 0 0 2 2 2 2 HMG-box domain CHDNT PF08073.12 AET39976.1 - 7.9e-09 35.4 0.2 6.8e-06 25.9 0.0 2.8 2 1 1 3 3 3 2 CHDNT (NUC034) domain Ccdc124 PF06244.12 AET39976.1 - 0.0016 18.9 1.4 0.73 10.4 0.1 2.3 2 0 0 2 2 2 2 Coiled-coil domain-containing protein 124 /Oxs1 Protamine_like PF06382.11 AET39976.1 - 0.035 14.3 0.1 0.085 13.0 0.0 1.7 1 1 0 1 1 1 0 Protamine and protamine like TrkH PF02386.16 AET39977.1 - 4.1e-169 563.2 16.1 4e-168 560.0 5.4 2.1 2 0 0 2 2 2 2 Cation transport protein Pkinase PF00069.25 AET39978.1 - 3.9e-60 203.4 0.1 9.5e-60 202.2 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET39978.1 - 2.7e-37 128.5 0.0 4.5e-37 127.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF5310 PF17237.2 AET39979.1 - 2.9e-20 71.8 2.1 2.9e-20 71.8 2.1 1.7 2 0 0 2 2 2 1 Family of unknown function (DUF5310) PNGaseA PF12222.8 AET39980.1 - 5.6e-75 252.8 1.6 5.6e-75 252.8 1.6 1.9 1 1 1 2 2 2 2 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A zf-H2C2 PF09337.10 AET39981.1 - 2.6e-15 56.3 1.7 5.9e-15 55.2 1.7 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Integrase_H2C2 PF17921.1 AET39981.1 - 1.2e-10 41.4 0.4 2.5e-10 40.3 0.4 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain Acetyltransf_1 PF00583.25 AET39981.1 - 6.7e-05 23.1 0.0 0.00021 21.5 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_CG PF14542.6 AET39981.1 - 0.076 13.2 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase CCD PF07860.11 AET39981.1 - 0.19 11.8 0.5 0.45 10.6 0.2 1.8 2 0 0 2 2 2 0 WisP family C-Terminal Region G6B PF15096.6 AET39981.1 - 0.59 9.9 3.8 0.14 11.9 0.3 1.7 2 0 0 2 2 2 0 G6B family GCD14 PF08704.10 AET39982.1 - 3.8e-77 259.3 0.0 3.8e-42 144.7 0.1 2.4 2 0 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit GCD14_N PF14801.6 AET39982.1 - 1.1e-05 25.1 0.1 3.9e-05 23.4 0.0 2.1 2 0 0 2 2 2 1 tRNA methyltransferase complex GCD14 subunit N-term Methyltransf_25 PF13649.6 AET39982.1 - 0.012 16.3 0.0 0.027 15.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 AET39982.1 - 0.023 14.5 0.0 0.053 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain FeoA PF04023.14 AET39982.1 - 0.025 14.8 0.1 0.14 12.4 0.0 2.1 2 0 0 2 2 2 0 FeoA domain PCMT PF01135.19 AET39982.1 - 0.05 13.3 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) ABC_tran_Xtn PF12848.7 AET39982.1 - 0.11 12.5 0.3 0.11 12.5 0.3 1.9 2 0 0 2 2 2 0 ABC transporter Acyl-CoA_dh_1 PF00441.24 AET39983.1 - 4.4e-18 65.9 0.1 1e-17 64.7 0.0 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 AET39983.1 - 7.6e-10 38.9 0.3 1.9e-09 37.6 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 AET39983.1 - 0.00061 20.4 0.0 0.001 19.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 AET39983.1 - 0.15 12.3 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain LSM PF01423.22 AET39984.1 - 3.2e-15 55.6 0.2 6e-15 54.7 0.2 1.4 1 0 0 1 1 1 1 LSM domain PUF PF00806.19 AET39984.1 - 0.052 13.3 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 Pumilio-family RNA binding repeat Kazal_3 PF18434.1 AET39984.1 - 0.056 13.2 0.3 0.098 12.4 0.3 1.3 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain DUF1687 PF07955.11 AET39985.1 - 1.4e-21 77.3 0.0 2.1e-21 76.7 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1687) DUF5427 PF10310.9 AET39986.1 - 2.1e-85 287.4 11.6 3.1e-85 286.9 11.6 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5427) Alb1 PF09135.11 AET39987.1 - 1.2e-17 64.7 6.8 1.2e-17 64.7 6.8 1.6 2 0 0 2 2 2 1 Alb1 RGI1 PF10843.8 AET39987.1 - 0.02 14.5 1.0 0.088 12.5 0.1 2.0 2 0 0 2 2 2 0 Respiratory growth induced protein 1 Ribul_P_3_epim PF00834.19 AET39988.1 - 2.9e-68 229.2 0.0 3.8e-68 228.8 0.0 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family OMPdecase PF00215.24 AET39988.1 - 0.015 14.9 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family QRPTase_C PF01729.19 AET39988.1 - 0.18 11.6 0.0 0.44 10.3 0.0 1.6 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain NAP PF00956.18 AET39989.1 - 7.5e-89 297.5 6.7 7.5e-89 297.5 6.7 1.7 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) BUD22 PF09073.10 AET39989.1 - 0.3 10.4 24.7 2.5 7.4 18.7 2.2 2 0 0 2 2 2 0 BUD22 PET10 PF17316.2 AET39990.1 - 1.8e-66 224.2 4.1 4.3e-65 219.7 4.1 2.6 1 1 0 1 1 1 1 Petite colonies protein 10 DUF4125 PF13526.6 AET39990.1 - 0.038 13.6 0.1 0.059 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4125) Glyco_hydro_28 PF00295.17 AET39992.1 - 6.6e-87 291.6 17.5 8.2e-87 291.3 17.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 AET39992.1 - 3.3e-11 43.3 19.2 3.3e-11 43.3 19.2 2.3 2 2 0 2 2 2 1 Right handed beta helix region NosD PF05048.13 AET39992.1 - 8.2e-05 22.0 17.2 0.00018 20.8 17.2 1.7 1 1 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Pho86 PF11124.8 AET39994.1 - 3.3e-102 341.9 1.0 3.7e-102 341.7 1.0 1.0 1 0 0 1 1 1 1 Inorganic phosphate transporter Pho86 Abi_2 PF07751.11 AET39994.1 - 0.11 12.7 0.1 0.19 12.0 0.1 1.3 1 0 0 1 1 1 0 Abi-like protein Methyltransf_13 PF08421.11 AET39994.1 - 0.16 12.2 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 Putative zinc binding domain Lectin_leg-like PF03388.13 AET39995.1 - 2.2e-16 59.9 0.2 2.2e-08 33.7 0.0 2.1 2 0 0 2 2 2 2 Legume-like lectin family Bact_lectin PF18483.1 AET39995.1 - 0.00079 19.5 0.1 0.0012 18.9 0.1 1.3 1 0 0 1 1 1 1 Bacterial lectin DUF4119 PF13494.6 AET39995.1 - 0.044 13.9 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF4119) His_Phos_1 PF00300.22 AET39996.1 - 6.2e-34 117.4 0.0 8.1e-34 117.0 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) SUN PF03856.13 AET39997.1 - 6.5e-94 314.0 10.4 9.4e-94 313.4 10.4 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) zf-MYND PF01753.18 AET39997.1 - 0.11 12.6 1.7 0.23 11.6 1.7 1.5 1 0 0 1 1 1 0 MYND finger SSTK-IP PF15836.5 AET39998.1 - 0.095 12.8 1.9 0.17 12.0 1.9 1.3 1 0 0 1 1 1 0 SSTK-interacting protein, TSSK6-activating co-chaperone protein Mg_trans_NIPA PF05653.14 AET39999.1 - 4.2e-11 42.5 12.5 6.5e-11 41.9 12.5 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA RE_R_Pab1 PF09522.10 AET39999.1 - 0.026 14.7 0.1 0.044 13.9 0.1 1.4 1 0 0 1 1 1 0 R.Pab1 restriction endonuclease Trp_oprn_chp PF09534.10 AET39999.1 - 6.5 6.5 8.3 12 5.6 0.3 2.8 2 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Multi_Drug_Res PF00893.19 AET39999.1 - 7.3 7.3 10.1 0.56 10.9 2.2 2.7 2 0 0 2 2 2 0 Small Multidrug Resistance protein ASF1_hist_chap PF04729.13 AET40000.1 - 2.6e-71 238.6 0.0 4e-71 237.9 0.0 1.3 1 0 0 1 1 1 1 ASF1 like histone chaperone PA26 PF04636.13 AET40000.1 - 0.3 9.9 1.6 0.37 9.6 1.6 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) BUD22 PF09073.10 AET40000.1 - 3.3 7.0 38.0 3.8 6.7 38.0 1.1 1 0 0 1 1 1 0 BUD22 Spore_YabQ PF09578.10 AET40002.1 - 0.012 15.8 0.1 0.026 14.7 0.1 1.4 1 0 0 1 1 1 0 Spore cortex protein YabQ (Spore_YabQ) Sec63 PF02889.16 AET40002.1 - 0.014 14.6 0.0 1.8 7.6 0.0 2.0 2 0 0 2 2 2 0 Sec63 Brl domain Pkinase PF00069.25 AET40003.1 - 1.3e-50 172.2 0.0 3.1e-50 171.0 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40003.1 - 3e-20 72.6 0.0 8.2e-20 71.2 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 AET40003.1 - 0.0001 22.0 0.0 0.089 12.4 0.0 2.6 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 AET40003.1 - 0.00029 20.8 0.0 1.2 9.0 0.0 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family RIO1 PF01163.22 AET40003.1 - 0.0042 16.7 1.4 0.014 15.0 0.8 2.1 1 1 1 2 2 2 1 RIO1 family Actin PF00022.19 AET40004.1 - 4.6e-110 368.0 0.0 1.5e-109 366.4 0.0 1.6 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 AET40004.1 - 0.0016 17.3 0.0 0.0053 15.6 0.0 1.7 1 1 0 1 1 1 1 MreB/Mbl protein Actin_micro PF17003.5 AET40004.1 - 0.19 10.8 0.6 0.43 9.7 0.1 1.7 2 0 0 2 2 2 0 Putative actin-like family PRIMA1 PF16101.5 AET40005.1 - 0.056 13.5 0.1 0.093 12.8 0.1 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Adap_comp_sub PF00928.21 AET40006.1 - 5.9e-76 255.3 0.3 7.4e-76 255.0 0.3 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Pribosyl_synth PF14572.6 AET40007.1 - 7e-40 137.0 0.1 1.2e-39 136.2 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 AET40007.1 - 1.6e-37 128.0 0.1 5e-37 126.4 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 AET40007.1 - 1.4e-11 44.1 0.7 1.3e-10 41.0 0.7 2.2 1 1 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AET40007.1 - 0.016 14.6 0.1 0.029 13.8 0.1 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Pkinase PF00069.25 AET40008.1 - 2.9e-50 171.1 0.0 4.5e-50 170.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40008.1 - 7.8e-22 77.8 0.0 1.3e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET40008.1 - 0.0014 18.0 0.0 0.0086 15.4 0.0 2.1 2 0 0 2 2 2 1 Kinase-like DUF21 PF01595.20 AET40009.1 - 2.2e-34 118.7 0.2 4.2e-34 117.8 0.2 1.4 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 AET40009.1 - 0.00037 20.9 0.1 0.65 10.5 0.0 2.9 3 0 0 3 3 3 2 CBS domain NAD_Gly3P_dh_N PF01210.23 AET40010.1 - 7.9e-52 175.4 0.0 1.4e-51 174.6 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 AET40010.1 - 7.8e-41 139.7 0.1 1.6e-40 138.6 0.1 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 AET40010.1 - 0.024 15.2 0.0 4.5 7.9 0.0 2.6 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.24 AET40010.1 - 0.046 14.2 0.0 0.19 12.2 0.0 2.1 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Arginosuc_synth PF00764.19 AET40011.1 - 5e-164 546.2 0.0 5.7e-164 546.0 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 AET40011.1 - 0.0002 20.9 0.0 0.00037 20.1 0.0 1.4 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 AET40011.1 - 0.00068 18.5 0.1 0.0011 17.9 0.1 1.3 1 0 0 1 1 1 1 tRNA methyl transferase Peptidase_M49 PF03571.15 AET40012.1 - 1.2e-227 756.8 0.0 1.5e-227 756.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M49 His_Phos_1 PF00300.22 AET40013.1 - 1.7e-30 106.2 0.0 1.6e-13 50.8 0.0 3.1 1 1 2 3 3 3 3 Histidine phosphatase superfamily (branch 1) Phos_pyr_kin PF08543.12 AET40014.1 - 2.3e-75 253.2 1.0 2.6e-75 253.0 1.0 1.0 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 AET40014.1 - 0.00021 20.7 0.6 0.033 13.5 0.1 2.4 2 1 0 2 2 2 2 pfkB family carbohydrate kinase HK PF02110.15 AET40014.1 - 0.31 10.4 5.3 0.25 10.7 0.7 2.6 1 1 1 2 2 2 0 Hydroxyethylthiazole kinase family Oxysterol_BP PF01237.18 AET40015.1 - 1.3e-133 445.5 0.0 3.2e-133 444.2 0.0 1.7 1 0 0 1 1 1 1 Oxysterol-binding protein PH PF00169.29 AET40015.1 - 1.4e-11 44.9 0.3 3.3e-11 43.6 0.3 1.7 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 AET40015.1 - 7.4e-09 35.8 0.1 2.5e-08 34.1 0.1 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain Ank_5 PF13857.6 AET40015.1 - 9.5e-08 32.2 0.0 0.019 15.3 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 AET40015.1 - 5.4e-07 30.1 0.0 0.018 15.6 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 AET40015.1 - 2.7e-06 27.9 0.0 0.079 13.6 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 AET40015.1 - 8.2e-06 25.8 0.2 0.18 12.5 0.0 4.0 4 0 0 4 4 3 2 Ankyrin repeat PH_11 PF15413.6 AET40015.1 - 0.00041 20.7 6.1 0.0026 18.2 1.0 3.4 2 1 0 2 2 2 1 Pleckstrin homology domain Ank PF00023.30 AET40015.1 - 0.012 16.1 0.0 0.4 11.2 0.1 3.2 2 0 0 2 2 2 0 Ankyrin repeat SIX1_SD PF16878.5 AET40015.1 - 0.11 13.0 1.5 5.4 7.6 0.0 3.5 2 1 1 3 3 3 0 Transcriptional regulator, SIX1, N-terminal SD domain DUF3761 PF12587.8 AET40015.1 - 4.1 7.9 7.9 0.19 12.1 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3761) Carn_acyltransf PF00755.20 AET40016.1 - 7.9e-202 672.0 0.0 8.9e-202 671.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Antimicrobial11 PF08106.11 AET40016.1 - 3.4 7.9 6.8 4.8 7.4 1.6 2.5 2 0 0 2 2 2 0 Formaecin family Pkinase PF00069.25 AET40017.1 - 3.1e-71 239.8 0.4 6.1e-71 238.9 0.4 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40017.1 - 5.4e-52 176.6 0.2 8.5e-52 176.0 0.2 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET40017.1 - 1.5e-07 31.0 0.2 4.9e-06 26.1 0.0 2.3 1 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 AET40017.1 - 0.0031 16.3 0.0 0.0049 15.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 AET40017.1 - 0.032 13.6 0.0 0.067 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 AET40017.1 - 0.1 12.1 0.7 0.22 11.0 0.7 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pkinase PF00069.25 AET40018.1 - 1.9e-58 197.9 0.0 7.7e-58 195.9 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40018.1 - 6e-34 117.5 0.0 3.2e-33 115.1 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AET40018.1 - 0.00019 20.4 0.0 0.0003 19.7 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 AET40018.1 - 0.03 14.2 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family SAICAR_synt PF01259.18 AET40019.1 - 2.6e-99 331.9 0.0 3.1e-99 331.7 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase UPF0086 PF01868.16 AET40019.1 - 0.16 11.9 0.1 2.2 8.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function UPF0086 SH3_1 PF00018.28 AET40020.1 - 2.5e-08 33.4 0.2 7.1e-08 31.9 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 AET40020.1 - 0.0011 18.8 0.1 0.0034 17.2 0.1 1.9 1 0 0 1 1 1 1 Variant SH3 domain DUF4228 PF14009.6 AET40020.1 - 0.0085 16.5 0.0 0.085 13.2 0.0 2.3 1 1 0 2 2 2 1 Domain of unknown function (DUF4228) DUF1179 PF06678.11 AET40020.1 - 0.46 10.5 3.5 0.32 11.0 1.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1179) Adaptin_binding PF10199.9 AET40020.1 - 4.6 7.9 12.6 2.7 8.6 1.2 3.4 2 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Jnk-SapK_ap_N PF09744.9 AET40020.1 - 8.4 6.6 7.7 30 4.8 0.0 2.6 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 HEAT PF02985.22 AET40021.1 - 7.5e-23 78.6 6.4 3.7e-05 23.6 0.0 8.4 8 0 0 8 8 8 4 HEAT repeat HEAT_EZ PF13513.6 AET40021.1 - 3.7e-22 78.4 4.0 1.5e-11 44.5 0.0 8.0 8 1 1 9 9 9 2 HEAT-like repeat HEAT_2 PF13646.6 AET40021.1 - 7.6e-17 61.5 0.0 4.4e-06 27.0 0.0 4.8 3 1 1 4 4 4 4 HEAT repeats Cnd1 PF12717.7 AET40021.1 - 1.4e-14 54.4 3.3 6.1e-05 23.1 0.0 3.7 3 0 0 3 3 3 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 AET40021.1 - 0.00036 21.1 1.5 5.2 7.7 0.0 4.8 4 1 2 6 6 6 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 AET40021.1 - 0.001 17.7 8.0 0.04 12.5 0.3 3.8 3 1 0 3 3 3 2 Adaptin N terminal region MMS19_C PF12460.8 AET40021.1 - 0.0011 18.2 6.5 1.3 8.1 0.4 4.5 4 1 1 5 5 5 2 RNAPII transcription regulator C-terminal TAF6_C PF07571.13 AET40021.1 - 0.044 14.1 0.0 7.1 7.0 0.0 3.9 3 1 1 4 4 4 0 TAF6 C-terminal HEAT repeat domain DUF3437 PF11919.8 AET40021.1 - 0.076 12.9 0.0 2.9 7.8 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) RasGEF_N_2 PF14663.6 AET40021.1 - 0.27 11.6 1.9 6.8 7.1 0.1 3.5 2 1 1 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain EGF_MSP1_1 PF12946.7 AET40021.1 - 0.36 10.9 1.2 0.51 10.4 0.2 1.9 2 0 0 2 2 2 0 MSP1 EGF domain 1 Amidohydro_1 PF01979.20 AET40022.1 - 2e-36 126.0 0.0 2.5e-36 125.7 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 AET40022.1 - 1.3e-10 41.4 0.2 7.5e-06 25.7 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family EMP24_GP25L PF01105.24 AET40023.1 - 5.6e-30 104.6 0.5 6.5e-30 104.4 0.5 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF3847 PF12958.7 AET40023.1 - 0.0066 16.5 0.3 0.011 15.9 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3847) Pkinase PF00069.25 AET40024.1 - 1.3e-37 129.6 0.0 4.7e-19 68.8 0.0 3.5 2 2 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AET40024.1 - 9.1e-13 48.1 0.0 2.3e-07 30.4 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 AET40024.1 - 0.011 14.5 0.0 0.02 13.7 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 AET40024.1 - 0.018 15.0 0.0 0.17 11.8 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family PapG_C PF03628.13 AET40024.1 - 0.051 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 PapG chaperone-binding domain FTA2 PF13095.6 AET40024.1 - 0.1 12.2 0.0 0.38 10.4 0.0 1.8 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 AET40024.1 - 0.12 11.7 0.0 14 4.9 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Steroid_dh PF02544.16 AET40025.1 - 1.3e-32 112.8 9.5 2.5e-32 112.0 9.5 1.4 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase Fibrillarin PF01269.17 AET40026.1 - 5.1e-106 352.9 0.0 6.2e-106 352.6 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 AET40026.1 - 1.2e-06 28.4 0.0 2e-06 27.7 0.0 1.3 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit FtsJ PF01728.19 AET40026.1 - 0.0068 16.5 0.0 0.0086 16.2 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.19 AET40026.1 - 0.026 14.3 0.0 0.043 13.6 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltr_RsmB-F PF01189.17 AET40026.1 - 0.055 13.1 0.0 0.11 12.2 0.0 1.5 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F Nuc_sug_transp PF04142.15 AET40027.1 - 1.3e-10 41.0 2.5 2.2e-10 40.2 2.5 1.4 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 AET40027.1 - 1.7e-09 37.3 15.0 2.5e-09 36.8 15.0 1.4 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 AET40027.1 - 6.5e-08 32.8 30.1 2.1e-05 24.7 14.5 2.8 2 2 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 AET40027.1 - 1.3e-07 31.3 13.3 1.3e-07 31.3 13.3 1.8 1 1 0 2 2 2 1 Triose-phosphate Transporter family SLC35F PF06027.12 AET40027.1 - 0.0088 15.6 18.8 0.045 13.2 18.8 1.9 1 1 0 1 1 1 1 Solute carrier family 35 Multi_Drug_Res PF00893.19 AET40027.1 - 0.17 12.6 8.6 0.11 13.2 1.4 2.8 2 0 0 2 2 2 0 Small Multidrug Resistance protein PUNUT PF16913.5 AET40027.1 - 0.29 10.3 16.6 0.0058 15.9 5.1 2.1 1 1 1 2 2 2 0 Purine nucleobase transmembrane transport TMEM234 PF10639.9 AET40027.1 - 0.73 9.9 9.9 0.072 13.1 2.8 2.8 3 0 0 3 3 3 0 Putative transmembrane family 234 CYSTM PF12734.7 AET40028.1 - 0.00092 19.5 65.3 0.25 11.7 43.0 5.3 1 1 1 2 2 2 1 Cysteine-rich TM module stress tolerance APOC4 PF15119.6 AET40029.1 - 0.045 14.0 0.2 0.099 12.9 0.2 1.5 1 0 0 1 1 1 0 Apolipoprotein C4 IRF-2BP1_2 PF11261.8 AET40029.1 - 0.13 11.9 0.5 0.38 10.3 0.5 1.7 1 0 0 1 1 1 0 Interferon regulatory factor 2-binding protein zinc finger Secretin_N_2 PF07655.13 AET40029.1 - 0.32 11.6 13.8 0.24 12.0 10.8 2.5 2 0 0 2 2 2 0 Secretin N-terminal domain Prefoldin PF02996.17 AET40030.1 - 1e-32 112.5 0.4 1.6e-32 111.9 0.4 1.3 1 0 0 1 1 1 1 Prefoldin subunit Pox_A_type_inc PF04508.12 AET40030.1 - 0.0001 22.0 1.7 0.00016 21.3 0.0 2.3 3 0 0 3 3 3 1 Viral A-type inclusion protein repeat UPF0242 PF06785.11 AET40030.1 - 0.03 14.4 1.4 0.35 11.0 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus SNAD4 PF18750.1 AET40030.1 - 0.046 13.8 0.1 0.11 12.6 0.1 1.6 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC_C PF05240.14 AET40030.1 - 0.05 13.6 0.1 4.7 7.2 0.0 2.3 2 0 0 2 2 2 0 APOBEC-like C-terminal domain DUF5475 PF17569.2 AET40030.1 - 0.12 12.7 1.0 1.6 9.1 0.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5475) SOGA PF11365.8 AET40030.1 - 0.32 12.2 2.8 4.4 8.5 0.4 2.3 2 0 0 2 2 2 0 Protein SOGA Mitoc_mL59 PF18126.1 AET40032.1 - 1.8e-27 96.2 0.1 2.8e-27 95.6 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein mL59 PRP38 PF03371.15 AET40033.1 - 3.5e-50 170.3 0.5 4e-50 170.1 0.5 1.0 1 0 0 1 1 1 1 PRP38 family AstE_AspA PF04952.14 AET40033.1 - 0.22 10.6 0.0 0.3 10.1 0.0 1.1 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family LSM PF01423.22 AET40034.1 - 5.4e-22 77.3 0.1 1.3e-21 76.1 0.1 1.6 1 1 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AET40034.1 - 0.0008 19.5 0.0 0.0015 18.7 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain Leu_zip PF15294.6 AET40035.1 - 0.0079 15.7 12.1 0.0079 15.7 12.1 1.6 1 1 1 2 2 2 1 Leucine zipper Scaffolding_pro PF11418.8 AET40035.1 - 0.013 16.1 0.9 0.026 15.1 0.9 1.6 1 0 0 1 1 1 0 Phi29 scaffolding protein Lzipper-MIP1 PF14389.6 AET40035.1 - 0.029 14.6 6.8 1.2 9.5 3.1 2.4 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 DivIVA PF05103.13 AET40035.1 - 0.27 11.3 9.5 0.82 9.8 0.3 3.0 3 0 0 3 3 3 0 DivIVA protein CENP-Q PF13094.6 AET40035.1 - 0.47 10.6 9.3 1.8 8.8 9.3 2.0 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit YabA PF06156.13 AET40035.1 - 0.51 11.0 13.0 1.7 9.3 2.0 2.9 1 1 1 2 2 2 0 Initiation control protein YabA PV-1 PF06637.11 AET40035.1 - 0.86 8.4 10.7 0.98 8.2 2.1 2.0 1 1 1 2 2 2 0 PV-1 protein (PLVAP) Syntaxin_2 PF14523.6 AET40035.1 - 2.1 8.8 16.0 1.5 9.2 11.5 2.2 2 0 0 2 2 2 0 Syntaxin-like protein APG6_N PF17675.1 AET40035.1 - 2.5 8.6 17.6 13 6.3 13.9 2.7 2 1 0 2 2 2 0 Apg6 coiled-coil region ZapB PF06005.12 AET40035.1 - 2.9 8.4 19.6 0.75 10.3 3.2 3.5 2 1 2 4 4 4 0 Cell division protein ZapB CENP-F_leu_zip PF10473.9 AET40035.1 - 3 7.9 19.3 2.9 7.9 14.8 2.6 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Bcr-Abl_Oligo PF09036.10 AET40035.1 - 3.3 7.8 5.7 2.3 8.3 0.4 2.6 1 1 1 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain PCI PF01399.27 AET40036.1 - 1.6e-13 51.0 0.3 1.6e-13 51.0 0.3 2.5 3 1 0 3 3 3 1 PCI domain DUF410 PF04190.13 AET40036.1 - 0.019 14.8 0.1 0.039 13.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF410) Metallophos PF00149.28 AET40037.1 - 1.2e-38 133.7 0.1 1.6e-38 133.3 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 AET40037.1 - 0.00067 20.1 0.2 0.0014 19.0 0.2 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Glyco_hydro_65N PF03636.15 AET40037.1 - 0.089 12.4 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain E1_DerP2_DerF2 PF02221.15 AET40038.1 - 8.5e-26 91.0 0.0 2.2e-25 89.6 0.0 1.7 2 0 0 2 2 2 1 ML domain Y_Y_Y PF07495.13 AET40038.1 - 0.07 13.1 0.1 0.82 9.7 0.0 2.5 2 0 0 2 2 2 0 Y_Y_Y domain Alph_Pro_TM PF09608.10 AET40038.1 - 0.14 12.0 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Putative transmembrane protein (Alph_Pro_TM) Sdh5 PF03937.16 AET40039.1 - 3.1e-25 87.9 0.1 4.6e-25 87.4 0.1 1.3 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase CHCH PF06747.13 AET40040.1 - 2e-06 27.8 0.2 2.7e-06 27.4 0.2 1.2 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.10 AET40040.1 - 0.011 15.7 0.2 0.013 15.5 0.2 1.1 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like PAPS_reduct PF01507.19 AET40041.1 - 2.5e-26 92.8 0.0 6.8e-26 91.3 0.0 1.7 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family SBDS_C PF09377.10 AET40042.1 - 0.02 14.9 2.5 0.032 14.3 0.2 2.5 2 1 0 2 2 2 0 SBDS protein C-terminal domain Closter_coat PF01785.17 AET40042.1 - 0.26 10.5 3.9 0.16 11.2 0.4 2.2 2 0 0 2 2 2 0 Closterovirus coat protein PPR_2 PF13041.6 AET40042.1 - 0.33 11.2 3.6 0.18 12.0 0.4 2.3 2 0 0 2 2 2 0 PPR repeat family FMO-like PF00743.19 AET40043.1 - 2.4e-15 55.9 3.1 1.3e-05 23.9 0.1 3.2 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 AET40043.1 - 0.00061 19.1 2.8 0.024 13.9 0.0 3.1 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 AET40043.1 - 0.0094 15.2 0.0 0.24 10.6 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 AET40043.1 - 0.012 14.8 0.1 0.31 10.2 0.0 2.9 3 1 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 AET40043.1 - 0.031 14.3 2.3 0.092 12.7 0.4 2.6 2 1 1 3 3 3 0 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 AET40043.1 - 0.13 12.5 2.0 0.2 11.9 0.2 2.3 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Nuf2 PF03800.14 AET40044.1 - 2.1e-40 138.1 0.3 2.1e-40 138.1 0.3 3.1 3 0 0 3 3 3 1 Nuf2 family DHR10 PF18595.1 AET40044.1 - 3e-08 33.7 18.1 3e-08 33.7 18.1 4.0 2 1 1 3 3 3 1 Designed helical repeat protein 10 domain Spc7 PF08317.11 AET40044.1 - 1.4 7.7 42.6 0.33 9.8 22.9 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein HMMR_N PF15905.5 AET40044.1 - 2 7.8 42.3 3.3 7.1 20.4 2.2 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF725 PF05267.12 AET40044.1 - 6.9 6.7 10.1 0.6 10.1 0.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF725) SF3A2 PF16835.5 AET40045.1 - 3.9e-21 75.2 0.0 7.7e-21 74.3 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 AET40045.1 - 4.9e-07 29.9 1.7 9.5e-07 29.0 1.7 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Csm4_C PF17953.1 AET40045.1 - 0.011 15.6 0.1 0.073 12.9 0.0 2.1 2 0 0 2 2 2 0 CRISPR Csm4 C-terminal domain zf-C2H2_2 PF12756.7 AET40045.1 - 0.03 14.7 0.1 0.066 13.5 0.1 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) DUF592 PF04574.13 AET40046.1 - 2.1e-66 222.5 0.4 3.9e-66 221.6 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF592) SIR2 PF02146.17 AET40046.1 - 1.8e-64 216.9 0.0 3e-64 216.2 0.0 1.4 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 AET40046.1 - 0.00072 19.3 0.0 0.19 11.5 0.0 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Paired_CXXCH_1 PF09699.10 AET40046.1 - 0.12 12.1 0.2 0.25 11.1 0.2 1.5 1 0 0 1 1 1 0 Doubled CXXCH motif (Paired_CXXCH_1) HLH PF00010.26 AET40047.1 - 9.1e-16 57.6 0.0 1.4e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Ku_C PF03730.14 AET40047.1 - 0.071 13.8 0.5 1.3 9.7 0.1 2.2 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm MbeD_MobD PF04899.12 AET40047.1 - 0.15 12.2 1.3 1.3 9.2 0.1 2.2 2 0 0 2 2 2 0 MbeD/MobD like AAA PF00004.29 AET40048.1 - 1.7e-40 138.5 0.0 2.8e-40 137.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AET40048.1 - 9.4e-10 38.1 0.1 1.9e-09 37.2 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 AET40048.1 - 3.8e-09 36.4 0.0 7.4e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 AET40048.1 - 7.8e-06 26.1 0.0 2e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 AET40048.1 - 1.5e-05 24.3 0.0 2.6e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 AET40048.1 - 1.8e-05 25.0 0.2 0.017 15.4 0.1 2.6 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.14 AET40048.1 - 7.1e-05 22.8 0.3 0.00038 20.5 0.0 2.4 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AET40048.1 - 0.00012 22.5 0.1 0.0031 17.9 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 AET40048.1 - 0.00082 19.2 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 AET40048.1 - 0.0029 17.8 0.1 0.0077 16.5 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 AET40048.1 - 0.0078 16.8 0.4 0.027 15.0 0.0 2.1 3 0 0 3 3 2 1 AAA domain AAA_14 PF13173.6 AET40048.1 - 0.011 15.8 0.0 0.024 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 AET40048.1 - 0.015 15.2 0.1 0.039 13.8 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 AET40048.1 - 0.016 15.4 0.0 0.031 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 AET40048.1 - 0.017 14.9 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 AET40048.1 - 0.021 14.1 0.1 0.053 12.7 0.1 1.7 1 1 0 1 1 1 0 TIP49 P-loop domain NTPase_1 PF03266.15 AET40048.1 - 0.021 14.8 0.4 0.26 11.2 0.0 2.6 3 0 0 3 3 3 0 NTPase ATPase PF06745.13 AET40048.1 - 0.035 13.5 0.1 0.49 9.7 0.1 2.4 1 1 0 2 2 2 0 KaiC RNA_helicase PF00910.22 AET40048.1 - 0.036 14.4 0.0 0.1 13.0 0.0 1.9 2 0 0 2 2 1 0 RNA helicase Mg_chelatase PF01078.21 AET40048.1 - 0.056 12.8 0.1 0.11 11.8 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 AET40048.1 - 0.057 13.0 1.3 0.46 10.0 0.3 2.3 1 1 1 2 2 2 0 AAA domain Zeta_toxin PF06414.12 AET40048.1 - 0.092 12.0 0.1 0.18 11.1 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 AET40048.1 - 0.096 12.6 0.1 0.59 10.0 0.1 2.1 1 1 1 2 2 2 0 NACHT domain AAA_24 PF13479.6 AET40048.1 - 0.13 12.0 1.3 0.27 10.9 0.3 2.2 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 AET40048.1 - 1.9 7.9 4.1 0.5 9.9 0.1 2.1 2 1 0 2 2 2 0 P-loop containing dynein motor region PP2C PF00481.21 AET40049.1 - 1.1e-72 244.8 0.2 1.9e-72 244.0 0.2 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C T2SS-T3SS_pil_N PF13629.6 AET40049.1 - 0.064 13.0 0.2 14 5.5 0.0 3.0 3 0 0 3 3 3 0 Pilus formation protein N terminal region Med2 PF11214.8 AET40050.1 - 1e-35 121.9 3.6 1e-35 121.9 3.6 2.3 2 1 0 2 2 2 1 Mediator complex subunit 2 DUF3232 PF11554.8 AET40050.1 - 0.002 18.5 0.1 0.0037 17.6 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3232) Med29 PF11568.8 AET40050.1 - 0.0024 18.1 2.1 0.0024 18.1 2.1 2.0 2 0 0 2 2 2 1 Mediator complex subunit 29 DUF3038 PF11237.8 AET40050.1 - 0.0034 17.4 0.6 0.0078 16.3 0.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3038) ATP-synt_DE_N PF02823.16 AET40051.1 - 1.8e-16 59.8 0.4 2.7e-16 59.2 0.4 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Granin PF01271.17 AET40051.1 - 0.073 12.0 0.1 0.089 11.7 0.1 1.1 1 0 0 1 1 1 0 Granin (chromogranin or secretogranin) Rad21_Rec8_N PF04825.13 AET40052.1 - 2.8e-21 75.7 0.2 5.2e-21 74.9 0.2 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 AET40052.1 - 1.6e-06 27.3 0.0 3.4e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein DRIM PF07539.12 AET40053.1 - 3.9e-161 537.5 9.0 3.9e-161 537.5 9.0 4.6 3 2 0 4 4 4 2 Down-regulated in metastasis UNC45-central PF11701.8 AET40053.1 - 0.1 12.5 14.4 3.8 7.4 0.0 6.8 7 1 0 7 7 7 0 Myosin-binding striated muscle assembly central HMG_box PF00505.19 AET40054.1 - 3.9e-15 56.0 2.8 7.4e-15 55.1 2.8 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 AET40054.1 - 9.1e-13 48.6 1.5 1.9e-12 47.6 1.5 1.6 1 0 0 1 1 1 1 HMG-box domain DUF155 PF02582.14 AET40055.1 - 1.3e-56 191.5 1.5 1.8e-56 191.0 1.5 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 UPF0449 PF15136.6 AET40055.1 - 0.029 14.8 0.0 0.077 13.5 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Bromo_TP_like PF17027.5 AET40055.1 - 0.062 13.5 0.5 0.39 10.9 0.0 2.4 3 0 0 3 3 3 0 Histone-fold protein Histone_H2A_C PF16211.5 AET40056.1 - 3.1e-21 74.8 1.0 5.1e-21 74.1 1.0 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 AET40056.1 - 4.1e-18 66.0 0.0 5.6e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AET40056.1 - 3.1e-06 27.4 0.0 5.1e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone LcrG PF07216.12 AET40056.1 - 0.065 13.2 0.0 0.099 12.6 0.0 1.4 1 0 0 1 1 1 0 LcrG protein Histone PF00125.24 AET40057.1 - 7.7e-20 71.6 2.8 1e-19 71.2 2.8 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AET40057.1 - 4.4e-06 26.9 0.9 6.7e-06 26.3 0.1 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 AET40057.1 - 0.0018 18.7 0.0 0.0033 17.9 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CENP-W PF15510.6 AET40057.1 - 0.0062 16.7 0.0 0.0092 16.2 0.0 1.2 1 0 0 1 1 1 1 CENP-W protein YscO-like PF16789.5 AET40057.1 - 0.053 13.6 0.2 0.064 13.3 0.2 1.1 1 0 0 1 1 1 0 YscO-like protein Thiamine_BP PF01910.17 AET40058.1 - 4e-27 93.9 0.0 4.7e-27 93.7 0.0 1.0 1 0 0 1 1 1 1 Thiamine-binding protein HTH_21 PF13276.6 AET40058.1 - 0.0016 18.6 0.0 0.0023 18.0 0.0 1.3 1 0 0 1 1 1 1 HTH-like domain ACT_6 PF13740.6 AET40058.1 - 0.068 13.2 0.0 7.9 6.6 0.0 2.4 1 1 1 2 2 2 0 ACT domain Trehalase PF01204.18 AET40059.1 - 3.2e-187 623.4 0.0 3.8e-187 623.2 0.0 1.0 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 AET40059.1 - 8.6e-17 60.6 0.5 1.6e-16 59.7 0.5 1.5 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain Ran_BP1 PF00638.18 AET40060.1 - 1.2e-52 177.3 0.5 1.6e-52 176.9 0.5 1.2 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 AET40060.1 - 7e-05 22.7 0.3 0.0018 18.2 0.3 2.2 1 1 0 1 1 1 1 WH1 domain VID27_PH PF17747.1 AET40060.1 - 0.03 14.6 0.0 0.047 14.0 0.0 1.4 1 0 0 1 1 1 0 VID27 PH-like domain Ig_3 PF13927.6 AET40060.1 - 0.094 13.3 0.0 0.45 11.2 0.0 2.2 1 1 0 1 1 1 0 Immunoglobulin domain Prenyltransf PF01255.19 AET40061.1 - 1.4e-73 247.1 0.0 1.7e-73 246.9 0.0 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase polyprenyl_synt PF00348.17 AET40062.1 - 4.1e-67 225.9 0.0 3.1e-65 219.8 0.0 2.8 1 1 0 1 1 1 1 Polyprenyl synthetase Mannosyl_trans2 PF04188.13 AET40063.1 - 3e-61 208.1 52.7 2.2e-41 142.6 37.0 2.3 1 1 1 2 2 2 2 Mannosyltransferase (PIG-V) RCR PF12273.8 AET40064.1 - 4.2e-30 104.9 3.9 4.2e-30 104.9 3.9 1.7 2 0 0 2 2 2 1 Chitin synthesis regulation, resistance to Congo red Aldedh PF00171.22 AET40065.1 - 1.2e-157 525.2 0.1 1.3e-157 525.0 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 AET40065.1 - 0.036 13.5 0.1 0.13 11.7 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) SelA PF03841.13 AET40065.1 - 0.13 11.2 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 L-seryl-tRNA selenium transferase Rad51 PF08423.11 AET40066.1 - 4.9e-46 157.1 0.1 1.1e-39 136.3 0.0 2.2 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.6 AET40066.1 - 1.9e-06 27.6 0.0 5.4e-06 26.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain RecA PF00154.21 AET40066.1 - 5.7e-05 22.7 0.8 0.0004 19.9 0.8 2.0 1 1 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 AET40066.1 - 0.0035 16.7 1.1 0.024 14.0 0.8 2.2 1 1 1 2 2 2 1 KaiC CobU PF02283.16 AET40066.1 - 0.0036 16.9 0.1 0.032 13.8 0.0 2.2 2 0 0 2 2 2 1 Cobinamide kinase / cobinamide phosphate guanyltransferase AAA_24 PF13479.6 AET40066.1 - 0.083 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AET40066.1 - 0.099 12.9 0.1 0.29 11.4 0.1 1.7 1 1 0 1 1 1 0 AAA domain Maf1 PF09174.10 AET40067.1 - 8.2e-41 140.0 18.0 8.7e-37 126.9 18.0 3.3 1 1 0 1 1 1 1 Maf1 regulator API5 PF05918.11 AET40067.1 - 0.47 9.2 11.0 0.77 8.5 11.0 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Spt20 PF12090.8 AET40067.1 - 0.81 9.3 27.1 1.5 8.4 27.1 1.4 1 0 0 1 1 1 0 Spt20 family GREB1 PF15782.5 AET40067.1 - 0.99 6.4 14.3 1.3 6.1 14.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ndc1_Nup PF09531.10 AET40067.1 - 2.1 6.9 11.2 3 6.4 11.2 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4407 PF14362.6 AET40067.1 - 5.2 6.3 9.5 9.2 5.5 9.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ALMT PF11744.8 AET40067.1 - 5.6 5.7 11.3 8.3 5.1 11.3 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter EIIBC-GUT_N PF03612.14 AET40067.1 - 6.5 6.5 6.9 13 5.5 6.9 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Tcp11 PF05794.13 AET40068.1 - 2.8e-143 478.2 0.4 2.8e-143 478.2 0.4 2.2 2 0 0 2 2 2 1 T-complex protein 11 DUF3511 PF12023.8 AET40068.1 - 0.47 10.3 1.4 1.4 8.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3511) GHL13 PF14883.6 AET40068.1 - 2.4 7.1 5.4 0.37 9.8 0.1 2.2 3 0 0 3 3 3 0 Hypothetical glycosyl hydrolase family 13 CENP-T_C PF15511.6 AET40069.1 - 1.5e-09 37.9 0.1 1.9e-09 37.6 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 AET40069.1 - 2e-05 24.9 0.1 2.4e-05 24.7 0.1 1.2 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 AET40069.1 - 4.5e-05 23.5 0.2 6.7e-05 23.0 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 AET40069.1 - 0.0001 22.5 0.1 0.00019 21.6 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 AET40069.1 - 0.00019 21.7 0.1 0.00027 21.3 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 AET40069.1 - 0.003 17.6 0.0 0.0036 17.4 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 AET40069.1 - 0.0066 16.4 0.0 0.0097 15.9 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.13 AET40069.1 - 0.04 14.4 0.2 0.069 13.7 0.1 1.4 1 1 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.24 AET40070.1 - 3.1e-49 166.7 3.4 3.4e-49 166.5 3.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 AET40070.1 - 2e-06 28.1 0.0 3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 AET40070.1 - 5.5e-05 23.8 1.3 6.9e-05 23.5 1.3 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 AET40070.1 - 0.00011 22.3 0.8 0.00015 21.9 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 AET40070.1 - 0.0018 18.5 0.9 0.0023 18.2 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 AET40070.1 - 0.035 14.2 0.2 0.058 13.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit PRAI PF00697.22 AET40071.1 - 2.7e-55 187.2 0.0 3.5e-55 186.8 0.0 1.1 1 0 0 1 1 1 1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Reprolysin PF01421.19 AET40071.1 - 0.11 12.3 0.0 0.31 10.9 0.0 1.7 2 0 0 2 2 2 0 Reprolysin (M12B) family zinc metalloprotease Pyrophosphatase PF00719.19 AET40072.1 - 1.3e-58 197.4 0.1 1.7e-58 197.0 0.1 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase zf-ANAPC11 PF12861.7 AET40073.1 - 2e-41 140.0 7.1 2.6e-41 139.6 7.1 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 AET40073.1 - 2.8e-20 72.3 11.9 2.8e-20 72.3 11.9 1.7 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 AET40073.1 - 2e-05 24.8 22.1 3.2e-05 24.2 18.5 2.8 2 1 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.6 AET40073.1 - 0.0021 18.0 13.4 0.041 13.8 14.4 2.3 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 AET40073.1 - 0.0072 16.3 11.3 0.033 14.2 8.1 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_4 PF14570.6 AET40073.1 - 0.011 15.5 14.7 0.012 15.3 1.9 3.2 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain zf-HIT PF04438.16 AET40073.1 - 0.013 15.4 3.0 0.013 15.4 3.0 2.2 2 0 0 2 2 2 0 HIT zinc finger zf-C3HC4_2 PF13923.6 AET40073.1 - 0.053 13.4 17.2 1.9 8.4 17.2 2.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 AET40073.1 - 0.066 12.6 0.8 0.1 11.9 0.8 1.4 1 1 0 1 1 1 0 Rtf2 RING-finger zf-HC5HC2H_2 PF13832.6 AET40073.1 - 0.19 11.9 8.2 0.11 12.6 5.3 2.0 1 1 1 2 2 2 0 PHD-zinc-finger like domain zf-C3HC4 PF00097.25 AET40073.1 - 0.21 11.5 19.6 0.34 10.8 17.2 2.5 2 1 0 2 2 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AET40073.1 - 0.23 11.3 13.7 0.62 10.0 8.9 2.4 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 AET40073.1 - 0.24 11.6 18.9 0.38 11.0 15.7 3.2 2 1 0 2 2 2 0 FANCL C-terminal domain zf-HC5HC2H PF13771.6 AET40073.1 - 0.82 10.0 10.1 3.7 7.9 10.1 2.1 1 1 1 2 2 2 0 PHD-like zinc-binding domain Zn_ribbon_17 PF17120.5 AET40073.1 - 1.1 8.9 14.4 0.6 9.8 10.4 2.3 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type Opy2 PF09463.10 AET40073.1 - 3.5 8.0 12.5 0.67 10.3 7.1 2.3 2 0 0 2 2 2 0 Opy2 protein zf-RING-like PF08746.11 AET40073.1 - 3.7 7.9 13.0 16 5.9 12.0 2.3 1 1 1 2 2 2 0 RING-like domain Glutaredoxin PF00462.24 AET40074.1 - 9.4e-12 45.0 0.0 1.5e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Mannosyl_trans3 PF11051.8 AET40075.1 - 7.2e-84 281.4 0.0 3.2e-83 279.3 0.0 1.9 2 0 0 2 2 2 1 Mannosyltransferase putative Nyv1_N PF09426.10 AET40075.1 - 0.097 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Vacuolar R-SNARE Nyv1 N terminal NatB_MDM20 PF09797.9 AET40077.1 - 1.9e-40 139.0 6.2 1.9e-40 139.0 6.2 2.6 3 1 0 3 3 3 1 N-acetyltransferase B complex (NatB) non catalytic subunit ANAPC16 PF17256.2 AET40077.1 - 0.098 13.0 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex, subunit 16 TPR_19 PF14559.6 AET40077.1 - 0.12 12.9 0.1 2.1 8.9 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat SapB_1 PF05184.15 AET40077.1 - 1.8 8.6 4.5 2.7 8.1 0.3 3.3 3 0 0 3 3 3 0 Saposin-like type B, region 1 ATP19 PF11022.8 AET40078.1 - 2.2e-18 66.4 0.0 2.5e-18 66.2 0.0 1.1 1 0 0 1 1 1 1 ATP synthase subunit K Sugar_tr PF00083.24 AET40079.1 - 1.1e-116 390.4 29.0 1.2e-116 390.2 29.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AET40079.1 - 1.7e-26 93.0 43.9 3.5e-20 72.2 24.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_S10 PF00450.22 AET40080.1 - 1.8e-127 426.2 1.0 2.2e-127 426.0 1.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Calici_coat_C PF08435.11 AET40080.1 - 0.012 15.1 0.2 0.024 14.2 0.2 1.4 1 0 0 1 1 1 0 Calicivirus coat protein C-terminal CRIM PF16978.5 AET40081.1 - 4.8e-37 127.2 0.7 5.7e-36 123.7 0.0 2.6 2 0 0 2 2 2 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 AET40081.1 - 1.9e-29 102.1 0.3 8.5e-29 100.0 0.3 2.2 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology TUG-UBL1 PF11470.8 AET40081.1 - 0.063 13.5 0.3 1.6 9.0 0.1 2.6 2 0 0 2 2 2 0 TUG ubiquitin-like domain RNase_T PF00929.24 AET40082.1 - 3.6e-17 63.4 0.0 1.5e-16 61.4 0.0 1.9 2 0 0 2 2 2 1 Exonuclease DNA_pol_A_exo1 PF01612.20 AET40082.1 - 8.5e-05 22.3 0.0 0.00036 20.3 0.0 1.9 1 1 0 1 1 1 1 3'-5' exonuclease RasGAP PF00616.19 AET40083.1 - 8.1e-23 81.2 2.5 3.3e-17 62.9 0.1 3.7 3 1 1 4 4 4 2 GTPase-activator protein for Ras-like GTPase Consortin_C PF15281.6 AET40083.1 - 0.025 14.6 0.1 0.067 13.2 0.1 1.7 1 0 0 1 1 1 0 Consortin C-terminus CNOT11 PF10155.9 AET40083.1 - 1.6 8.9 7.3 0.28 11.3 0.1 3.6 4 0 0 4 4 4 0 CCR4-NOT transcription complex subunit 11 Bmt2 PF11968.8 AET40084.1 - 2.9e-79 266.0 0.2 3.8e-79 265.6 0.2 1.1 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 AET40084.1 - 0.06 13.2 0.0 0.093 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DEAD PF00270.29 AET40085.1 - 4.3e-39 134.1 0.0 8.9e-39 133.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET40085.1 - 3.8e-30 104.5 0.0 8.2e-28 97.0 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET40085.1 - 8.4e-09 35.6 0.5 2e-08 34.4 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 AET40085.1 - 0.047 14.0 0.4 0.19 12.0 0.4 2.1 1 1 0 1 1 1 0 AAA domain Mig-14 PF07395.11 AET40085.1 - 0.051 12.9 0.2 0.12 11.7 0.2 1.6 1 0 0 1 1 1 0 Mig-14 AAA PF00004.29 AET40085.1 - 0.37 11.2 1.8 1.4 9.4 0.1 2.6 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) eRF1_2 PF03464.15 AET40086.1 - 8.1e-46 155.6 0.1 1.3e-45 154.9 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 AET40086.1 - 1.4e-38 131.8 0.5 3e-38 130.8 0.5 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 AET40086.1 - 1e-20 74.1 0.0 1.7e-20 73.4 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 AET40086.1 - 1e-09 38.8 0.1 1.7e-09 38.1 0.1 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 AET40086.1 - 1.6e-08 34.9 0.3 2.8e-08 34.1 0.1 1.5 2 0 0 2 2 2 1 Bacterial archaeo-eukaryotic release factor family 10 ATG19_autophagy PF12744.7 AET40087.1 - 3.4e-20 72.3 1.1 6.4e-20 71.4 1.1 1.5 1 0 0 1 1 1 1 Autophagy protein Atg19, Atg8-binding ZZ PF00569.17 AET40087.1 - 3.1e-17 62.1 44.7 2.5e-06 27.2 4.3 6.4 5 1 1 6 6 6 3 Zinc finger, ZZ type NKAIN PF05640.14 AET40087.1 - 0.16 11.2 0.0 0.37 10.0 0.0 1.5 1 0 0 1 1 1 0 Na,K-Atpase Interacting protein CENP-B_dimeris PF09026.10 AET40087.1 - 6.3 7.2 13.0 20 5.7 13.0 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RSN1_7TM PF02714.15 AET40088.1 - 1.5e-87 293.4 22.9 1.5e-87 293.4 22.9 2.3 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 AET40088.1 - 6.8e-40 136.4 4.2 6.8e-40 136.4 4.2 2.4 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_ext PF12621.8 AET40088.1 - 5.1e-24 84.3 0.2 1.1e-23 83.2 0.2 1.6 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter PHM7_cyt PF14703.6 AET40088.1 - 2.3e-23 83.3 0.0 4.1e-23 82.5 0.0 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter FCH PF00611.23 AET40088.1 - 0.069 13.4 0.2 0.15 12.3 0.2 1.5 1 0 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain RRM_1 PF00076.22 AET40088.1 - 0.16 11.8 0.0 0.53 10.1 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Gp_dh_C PF02800.20 AET40089.1 - 2.6e-71 238.3 0.0 4.9e-71 237.4 0.0 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 AET40089.1 - 7.1e-40 135.4 0.0 1.6e-39 134.3 0.0 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 AET40089.1 - 0.0023 18.1 0.2 0.007 16.5 0.2 2.0 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus ADH_N PF08240.12 AET40090.1 - 1.4e-29 102.1 0.1 3e-29 101.1 0.1 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AET40090.1 - 1e-25 90.2 0.9 1.6e-25 89.5 0.9 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AET40090.1 - 4.5e-06 27.7 0.2 7.7e-06 27.0 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Epimerase PF01370.21 AET40090.1 - 0.056 12.9 0.1 0.079 12.4 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Ribosomal_S9 PF00380.19 AET40091.1 - 1.3e-43 148.4 0.4 1.8e-43 147.9 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S9/S16 CENP-S PF15630.6 AET40092.1 - 1.4e-25 89.5 0.0 1.8e-25 89.1 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 AET40092.1 - 2.3e-06 27.7 0.0 2.9e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID-18kDa PF02269.16 AET40092.1 - 0.12 12.5 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit DUF3337 PF11816.8 AET40093.1 - 2.5e-28 99.1 0.8 4.8e-28 98.2 0.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 AET40093.1 - 0.00013 22.6 3.1 0.044 14.7 0.0 5.0 5 0 0 5 5 5 1 WD domain, G-beta repeat RAWUL PF16207.5 AET40093.1 - 0.011 16.4 0.1 0.034 14.8 0.1 1.8 1 0 0 1 1 1 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like Rad60-SLD_2 PF13881.6 AET40093.1 - 0.028 14.5 0.1 0.072 13.2 0.1 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like RNA_pol_Rpb5_C PF01191.19 AET40094.1 - 2.3e-32 110.7 0.4 4.5e-32 109.7 0.4 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 AET40094.1 - 7.8e-29 100.1 0.2 1.5e-28 99.2 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Sof1 PF04158.14 AET40094.1 - 0.0085 16.3 0.2 0.016 15.5 0.2 1.4 1 0 0 1 1 1 1 Sof1-like domain RibD_C PF01872.17 AET40095.1 - 3.6e-30 105.3 0.0 4e-30 105.1 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain MFAP1 PF06991.11 AET40096.1 - 3.5e-05 23.8 7.7 3.5e-05 23.8 7.7 1.9 1 1 1 2 2 2 1 Microfibril-associated/Pre-mRNA processing TM231 PF10149.9 AET40096.1 - 0.11 11.9 1.0 0.14 11.5 1.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 231 LMBR1 PF04791.16 AET40096.1 - 3.8 6.3 5.8 4 6.2 5.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Pyrid_oxidase_2 PF13883.6 AET40097.1 - 1.8e-35 122.4 0.1 2.4e-35 122.0 0.1 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Gemin6 PF06372.12 AET40097.1 - 0.11 12.1 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Gemin6 protein Thioredoxin PF00085.20 AET40098.1 - 4.3e-14 52.4 0.1 1.5e-13 50.6 0.1 1.8 2 0 0 2 2 2 1 Thioredoxin Thr_dehydrat_C PF00585.18 AET40098.1 - 0.0095 15.7 0.1 0.12 12.1 0.0 2.3 2 0 0 2 2 2 1 C-terminal regulatory domain of Threonine dehydratase OST3_OST6 PF04756.13 AET40098.1 - 0.013 14.9 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 AET40098.1 - 0.026 14.8 0.1 0.11 12.9 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin-like Suc_Fer-like PF06999.12 AET40099.1 - 5e-48 163.6 0.0 6.2e-48 163.3 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like DUF1284 PF06935.11 AET40099.1 - 0.063 13.7 0.3 0.1 13.1 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1284) CRAL_TRIO PF00650.20 AET40100.1 - 1.3e-42 145.2 0.1 2.8e-42 144.1 0.0 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 AET40100.1 - 2.7e-12 46.7 0.1 9.8e-12 44.9 0.1 2.0 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 AET40100.1 - 1.3e-05 25.4 0.0 2.4e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain COMPASS-Shg1 PF05205.12 AET40101.1 - 0.075 13.7 0.0 0.27 11.9 0.0 2.0 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 tRNA-synt_1 PF00133.22 AET40102.1 - 1.5e-49 168.8 0.3 1.7e-29 102.6 0.4 5.9 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 AET40102.1 - 5.2e-40 136.9 0.0 1.1e-39 135.8 0.0 1.6 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 AET40102.1 - 1.5e-25 89.8 0.4 6.6e-20 71.2 0.0 5.0 4 1 1 5 5 5 4 tRNA synthetases class I (M) Anticodon_1 PF08264.13 AET40102.1 - 0.00012 22.0 0.3 0.00012 22.0 0.3 2.3 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA zf-ribbon_3 PF13248.6 AET40102.1 - 0.0017 17.7 2.9 1 8.8 0.3 2.4 2 0 0 2 2 2 2 zinc-ribbon domain DNA_ligase_ZBD PF03119.16 AET40102.1 - 0.012 15.6 0.0 0.038 14.0 0.0 1.9 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain tRNA-synt_1c PF00749.21 AET40102.1 - 0.016 14.1 0.4 4.5 6.1 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain Zn-ribbon_8 PF09723.10 AET40102.1 - 0.021 14.9 1.8 0.17 12.0 0.1 2.7 3 0 0 3 3 3 0 Zinc ribbon domain DZR PF12773.7 AET40102.1 - 0.18 11.9 0.1 0.43 10.7 0.1 1.6 1 1 0 1 1 1 0 Double zinc ribbon SMC_N PF02463.19 AET40103.1 - 9.5e-18 64.4 31.5 7.7e-17 61.5 31.5 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 AET40103.1 - 6.8e-10 39.2 29.4 6.8e-10 39.2 29.4 3.7 2 2 0 2 2 1 1 AAA ATPase domain AAA_23 PF13476.6 AET40103.1 - 2e-09 38.3 33.6 2e-09 38.3 33.6 5.2 2 2 0 2 2 1 1 AAA domain AAA_21 PF13304.6 AET40103.1 - 3e-07 30.5 6.5 0.00011 22.1 0.2 3.5 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_hinge PF06470.13 AET40103.1 - 7.5e-06 26.2 0.0 3.6e-05 24.0 0.0 2.2 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_29 PF13555.6 AET40103.1 - 0.00023 20.9 0.0 0.0005 19.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.6 AET40103.1 - 0.0004 19.2 15.1 0.0004 19.2 15.1 5.2 3 2 2 5 5 5 3 AAA domain AAA_27 PF13514.6 AET40103.1 - 0.013 15.1 0.1 0.013 15.1 0.1 4.2 4 2 1 6 6 6 0 AAA domain DUF948 PF06103.11 AET40103.1 - 0.076 13.3 0.2 0.076 13.3 0.2 6.6 5 1 0 6 6 6 0 Bacterial protein of unknown function (DUF948) ABC_tran PF00005.27 AET40103.1 - 0.11 13.0 0.0 0.11 13.0 0.0 5.7 4 2 0 4 4 2 0 ABC transporter Atg14 PF10186.9 AET40103.1 - 1.2 8.1 57.9 0.024 13.7 13.0 4.6 2 2 2 4 4 4 0 Vacuolar sorting 38 and autophagy-related subunit 14 GAS PF13851.6 AET40103.1 - 5.9 6.2 85.1 0.0091 15.4 6.8 6.4 4 2 1 5 5 5 0 Growth-arrest specific micro-tubule binding DASH_Duo1 PF08651.10 AET40103.1 - 6.6 6.6 9.3 6.4 6.6 0.2 5.0 4 1 0 4 4 4 0 DASH complex subunit Duo1 Uso1_p115_head PF04869.14 AET40104.1 - 5.8e-99 331.1 2.2 5.8e-99 331.1 2.2 2.8 2 1 1 3 3 3 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 AET40104.1 - 7.2e-13 49.0 20.2 7.2e-13 49.0 20.2 7.7 2 2 5 7 7 7 3 Uso1 / p115 like vesicle tethering protein, C terminal region Spc7 PF08317.11 AET40104.1 - 5e-05 22.3 116.3 0.12 11.3 22.5 6.1 1 1 3 5 5 5 4 Spc7 kinetochore protein DUF3584 PF12128.8 AET40104.1 - 5.8e-05 20.8 45.3 5.8e-05 20.8 45.3 3.5 1 1 2 3 3 3 2 Protein of unknown function (DUF3584) Arm_vescicular PF18770.1 AET40104.1 - 0.00011 22.1 0.0 0.00031 20.6 0.0 1.9 1 0 0 1 1 1 1 Armadillo tether-repeat of vescicular transport factor GAS PF13851.6 AET40104.1 - 0.0011 18.4 121.2 0.0018 17.7 15.6 7.4 1 1 6 7 7 7 4 Growth-arrest specific micro-tubule binding Filament PF00038.21 AET40104.1 - 0.005 16.5 35.7 0.005 16.5 35.7 5.7 1 1 2 4 4 4 2 Intermediate filament protein ATG16 PF08614.11 AET40104.1 - 0.19 11.9 112.1 0.014 15.6 17.8 5.8 1 1 5 6 6 6 0 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 AET40104.1 - 0.24 11.4 127.6 0.23 11.5 15.3 7.8 1 1 6 7 7 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4407 PF14362.6 AET40104.1 - 3.5 6.9 70.4 0.66 9.3 16.0 5.1 1 1 3 4 4 3 0 Domain of unknown function (DUF4407) Myosin_tail_1 PF01576.19 AET40104.1 - 4.3 5.0 115.7 0.092 10.5 57.8 2.2 1 1 1 2 2 2 0 Myosin tail MAD PF05557.13 AET40104.1 - 4.8 5.4 108.0 0.0038 15.7 9.9 4.6 1 1 3 4 4 4 0 Mitotic checkpoint protein Shisa PF13908.6 AET40105.1 - 0.0027 18.0 0.3 0.0054 17.0 0.2 1.7 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator Podoplanin PF05808.11 AET40105.1 - 0.1 12.7 1.6 0.15 12.2 0.9 1.5 2 0 0 2 2 2 0 Podoplanin TMEM52 PF14979.6 AET40105.1 - 1.5 8.7 5.3 5.2 7.0 1.4 2.4 2 0 0 2 2 2 0 Transmembrane 52 Y_phosphatase2 PF03162.13 AET40106.1 - 2.7e-56 189.7 0.0 3.4e-56 189.4 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 AET40106.1 - 1.8e-05 24.8 0.0 5.7e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 AET40106.1 - 0.039 13.8 0.0 0.057 13.2 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AET40106.1 - 0.17 11.4 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DAD PF02109.16 AET40107.1 - 7.3e-37 126.0 3.6 8.6e-37 125.8 3.6 1.1 1 0 0 1 1 1 1 DAD family PalH PF08733.10 AET40107.1 - 0.0041 16.2 1.4 0.0047 16.0 1.4 1.0 1 0 0 1 1 1 1 PalH/RIM21 Cytochrom_B_C PF00032.17 AET40107.1 - 0.063 13.6 4.6 0.18 12.1 1.0 2.1 1 1 1 2 2 2 0 Cytochrome b(C-terminal)/b6/petD Ras PF00071.22 AET40108.1 - 1.2e-55 187.5 0.2 1.5e-55 187.2 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET40108.1 - 1.9e-19 70.0 0.0 2.7e-19 69.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET40108.1 - 1.4e-09 37.6 0.0 1.7e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 AET40108.1 - 0.00024 20.7 0.2 0.0012 18.5 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AET40108.1 - 0.00076 19.4 0.1 0.41 10.5 0.0 2.5 2 1 1 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 AET40108.1 - 0.0024 17.9 0.0 0.0038 17.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 AET40108.1 - 0.11 12.6 0.1 0.32 11.0 0.0 1.8 1 1 1 2 2 2 0 C-terminal region of MMR_HSR1 domain ING PF12998.7 AET40109.1 - 1.7e-24 86.3 1.5 2.7e-24 85.7 0.0 2.0 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 AET40109.1 - 2.5e-05 24.1 8.6 4.9e-05 23.1 8.6 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 AET40109.1 - 0.0023 18.1 1.1 0.0057 16.9 1.1 1.7 1 0 0 1 1 1 1 PHD-like zinc-binding domain PHD_2 PF13831.6 AET40109.1 - 0.017 14.7 2.2 0.039 13.5 2.2 1.6 1 0 0 1 1 1 0 PHD-finger TSP9 PF11493.8 AET40109.1 - 0.079 13.6 1.2 0.24 12.1 1.2 1.8 1 0 0 1 1 1 0 Thylakoid soluble phosphoprotein TSP9 BST2 PF16716.5 AET40109.1 - 0.081 13.5 0.2 0.081 13.5 0.2 2.4 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 DUF3371 PF11851.8 AET40109.1 - 0.4 11.8 4.8 0.88 10.7 4.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3371) Macoilin PF09726.9 AET40109.1 - 0.95 7.9 7.8 1.1 7.7 7.8 1.1 1 0 0 1 1 1 0 Macoilin family Serglycin PF04360.12 AET40109.1 - 2.1 8.3 8.6 99 2.9 8.4 3.0 1 1 1 2 2 2 0 Serglycin Mito_carr PF00153.27 AET40110.1 - 7.1e-53 176.5 3.9 2.8e-18 65.6 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_transf_15 PF01793.16 AET40111.1 - 2e-126 421.7 17.9 2.4e-126 421.4 17.9 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Ribosomal_S7e PF01251.18 AET40112.1 - 6.8e-81 270.4 1.7 8.1e-81 270.2 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Rib_5-P_isom_A PF06026.14 AET40113.1 - 3.3e-59 199.4 0.0 4e-59 199.1 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Arf PF00025.21 AET40114.1 - 9.7e-71 236.8 0.1 1.1e-70 236.6 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 AET40114.1 - 1.5e-15 57.4 0.0 2.1e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 AET40114.1 - 1.3e-13 50.9 0.0 1.5e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 AET40114.1 - 4.4e-13 49.1 0.7 2.4e-08 33.6 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 AET40114.1 - 3e-12 46.4 0.0 3.7e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 AET40114.1 - 3.5e-10 39.6 0.0 4.5e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AET40114.1 - 1.1e-05 25.5 0.0 1.6e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AMP-binding PF00501.28 AET40115.1 - 3.8e-39 134.5 0.0 1.8e-12 46.6 0.0 5.1 5 0 0 5 5 5 5 AMP-binding enzyme DMAP_binding PF06464.11 AET40115.1 - 4.3e-05 24.3 0.6 0.00046 21.0 0.2 2.7 2 0 0 2 2 2 1 DMAP1-binding Domain Mem_trans PF03547.18 AET40116.1 - 4.6e-22 77.9 4.4 6.4e-22 77.5 4.4 1.2 1 0 0 1 1 1 1 Membrane transport protein DUF2183 PF09949.9 AET40117.1 - 2.6e-31 107.9 0.1 1.2e-30 105.7 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) DUF148 PF02520.17 AET40117.1 - 0.0013 18.8 0.0 0.25 11.5 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function DUF148 Carbam_trans_C PF16861.5 AET40117.1 - 0.62 9.6 2.3 0.72 9.4 0.4 1.9 2 0 0 2 2 2 0 Carbamoyltransferase C-terminus DFRP_C PF16543.5 AET40118.1 - 5.4e-23 81.3 10.2 5.4e-23 81.3 10.2 3.5 3 1 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH PF00642.24 AET40118.1 - 5.2e-05 23.0 0.3 5.2e-05 23.0 0.3 2.5 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 AET40118.1 - 6.3e-05 22.7 7.2 0.004 16.9 1.1 3.4 3 0 0 3 3 3 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 AET40118.1 - 8.3e-05 22.5 3.6 8.3e-05 22.5 3.6 3.1 3 0 0 3 3 3 1 Zinc finger domain Torus PF16131.5 AET40118.1 - 0.00023 21.8 12.1 0.00077 20.1 1.8 3.4 2 1 1 3 3 3 2 Torus domain zf-CCCH_2 PF14608.6 AET40118.1 - 0.0041 17.5 9.7 0.55 10.8 1.6 2.7 2 1 0 2 2 2 2 RNA-binding, Nab2-type zinc finger Lipoprotein_2 PF00921.17 AET40118.1 - 0.0067 16.0 2.0 0.0067 16.0 2.0 2.2 2 0 0 2 2 2 1 Borrelia lipoprotein zf-CCCH_3 PF15663.5 AET40118.1 - 2.3 8.5 6.9 2.3 8.4 0.4 2.8 2 1 1 3 3 3 0 Zinc-finger containing family PP2C PF00481.21 AET40119.1 - 1.3e-45 156.1 0.0 2.1e-45 155.4 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C Ras PF00071.22 AET40120.1 - 1.3e-59 200.5 0.0 1.5e-59 200.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET40120.1 - 6.2e-36 123.2 0.0 8.9e-36 122.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET40120.1 - 2e-17 63.2 0.0 2.3e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AET40120.1 - 5.3e-08 32.5 0.0 6.9e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AET40120.1 - 1.1e-05 25.5 0.0 1.9e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AET40120.1 - 2.8e-05 24.1 0.1 0.025 14.5 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 AET40120.1 - 4.4e-05 23.1 0.0 5.5e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 AET40120.1 - 0.07 13.5 0.1 0.13 12.6 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain Ion_trans PF00520.31 AET40121.1 - 1.5e-05 24.4 16.5 3.5e-05 23.2 16.5 1.6 1 1 0 1 1 1 1 Ion transport protein EMC3_TMCO1 PF01956.16 AET40121.1 - 0.0053 16.5 1.2 1.1 9.0 0.3 2.8 2 1 0 2 2 2 2 Integral membrane protein EMC3/TMCO1-like DivIC PF04977.15 AET40121.1 - 0.057 13.2 1.4 0.18 11.6 0.0 2.6 3 0 0 3 3 3 0 Septum formation initiator NST1 PF13945.6 AET40122.1 - 7.7e-10 39.2 5.9 7.7e-10 39.2 5.9 5.4 5 3 1 6 6 6 1 Salt tolerance down-regulator Ras PF00071.22 AET40123.1 - 6.4e-51 172.2 0.0 7.3e-51 172.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET40123.1 - 6.6e-23 81.2 0.0 9.1e-23 80.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET40123.1 - 4.4e-09 36.0 0.0 5.7e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 AET40123.1 - 0.00011 22.0 0.0 0.15 11.8 0.0 2.4 3 0 0 3 3 3 2 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 AET40123.1 - 0.036 13.5 0.0 0.053 12.9 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF1310 PF07006.11 AET40123.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1310) Glyco_hydro_61 PF03443.14 AET40123.1 - 0.12 12.2 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 61 G-alpha PF00503.20 AET40123.1 - 0.17 11.0 0.0 0.21 10.7 0.0 1.3 1 1 0 1 1 1 0 G-protein alpha subunit AAA_21 PF13304.6 AET40123.1 - 0.18 11.5 0.0 0.23 11.2 0.0 1.1 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system C2 PF00168.30 AET40124.1 - 1.5e-66 221.1 1.8 1.4e-19 70.3 0.0 4.4 4 0 0 4 4 4 4 C2 domain SMP_LBD PF17047.5 AET40124.1 - 0.00083 18.9 0.1 0.0015 18.1 0.1 1.3 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain Snapin_Pallidin PF14712.6 AET40125.1 - 1.2e-05 25.7 2.9 1.4e-05 25.4 2.9 1.1 1 0 0 1 1 1 1 Snapin/Pallidin Tmemb_cc2 PF10267.9 AET40125.1 - 0.00049 19.4 0.6 0.00054 19.2 0.6 1.0 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein BLOC1_2 PF10046.9 AET40125.1 - 0.02 15.2 2.3 0.025 14.9 2.3 1.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 COG2 PF06148.11 AET40125.1 - 0.15 12.1 2.7 0.19 11.8 2.7 1.1 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 YabA PF06156.13 AET40125.1 - 0.19 12.4 1.9 2.2 9.0 1.2 2.0 1 1 1 2 2 2 0 Initiation control protein YabA OST3_OST6 PF04756.13 AET40126.1 - 7.2e-84 281.6 1.0 8.2e-84 281.4 1.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family LMBR1 PF04791.16 AET40126.1 - 0.002 17.1 0.6 0.0037 16.3 0.6 1.4 1 0 0 1 1 1 1 LMBR1-like membrane protein Thioredoxin PF00085.20 AET40126.1 - 0.027 14.5 0.0 0.072 13.1 0.0 1.7 1 1 0 1 1 1 0 Thioredoxin DHHC PF01529.20 AET40126.1 - 7.4 6.7 6.7 1.1 9.3 1.3 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase MKT1_C PF12246.8 AET40127.1 - 1.1e-57 195.1 1.3 4e-57 193.2 1.5 1.8 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 AET40127.1 - 8e-29 99.8 0.1 3.3e-28 97.9 0.1 2.2 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 AET40127.1 - 2.6e-17 63.2 0.0 1.1e-16 61.2 0.0 2.1 2 0 0 2 2 2 1 XPG N-terminal domain Cpn60_TCP1 PF00118.24 AET40128.1 - 4.1e-146 487.5 11.1 4.7e-146 487.3 11.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF2264 PF10022.9 AET40128.1 - 0.11 11.6 0.0 0.22 10.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2264) CRM1_repeat PF18777.1 AET40128.1 - 0.16 11.5 0.0 0.34 10.5 0.0 1.5 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat EF-hand_4 PF12763.7 AET40129.1 - 1.5e-50 169.5 1.9 9.3e-49 163.7 0.9 2.4 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand End3 PF12761.7 AET40129.1 - 8.5e-47 159.9 0.0 1.2e-46 159.4 0.0 1.2 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_1 PF00036.32 AET40129.1 - 0.0093 15.5 0.9 0.031 13.8 0.9 2.0 1 0 0 1 1 1 1 EF hand Lzipper-MIP1 PF14389.6 AET40129.1 - 0.019 15.3 3.1 0.071 13.4 1.3 2.7 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Ig_3 PF13927.6 AET40129.1 - 0.12 13.0 0.1 0.33 11.6 0.0 1.8 2 0 0 2 2 2 0 Immunoglobulin domain ABC_tran_CTD PF16326.5 AET40129.1 - 0.14 12.4 3.4 8.9 6.6 0.3 2.4 1 1 0 2 2 2 0 ABC transporter C-terminal domain Spc24 PF08286.11 AET40129.1 - 0.14 12.4 2.1 12 6.2 0.2 2.6 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 FlaC_arch PF05377.11 AET40129.1 - 0.26 11.7 3.7 9.8 6.7 0.2 2.9 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) GIT_CC PF16559.5 AET40129.1 - 2.9 7.8 7.2 18 5.3 1.4 3.2 3 1 1 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor He_PIG PF05345.12 AET40130.1 - 2.8e-09 37.0 10.6 0.0074 16.5 0.0 5.8 6 0 0 6 6 6 2 Putative Ig domain TMEM154 PF15102.6 AET40130.1 - 2.7e-05 24.1 0.1 0.0001 22.2 0.1 2.0 1 0 0 1 1 1 1 TMEM154 protein family SKG6 PF08693.10 AET40130.1 - 0.0026 17.1 0.1 0.0069 15.8 0.1 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain RIFIN PF02009.16 AET40130.1 - 0.0074 16.2 0.1 0.014 15.3 0.1 1.4 1 0 0 1 1 1 1 Rifin Stevor PF17410.2 AET40130.1 - 0.12 11.9 0.2 0.23 11.0 0.2 1.4 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Orf78 PF06024.12 AET40130.1 - 0.12 12.7 0.1 0.43 10.9 0.0 1.9 2 0 0 2 2 2 0 Orf78 (ac78) BACON PF13004.7 AET40130.1 - 0.27 11.2 7.1 0.05 13.6 0.6 3.0 3 0 0 3 3 3 0 Putative binding domain, N-terminal 4HBT PF03061.22 AET40131.1 - 5.1e-07 30.0 0.4 0.023 15.0 0.1 2.8 2 1 1 3 3 3 2 Thioesterase superfamily Mito_carr PF00153.27 AET40132.1 - 3.2e-60 200.1 3.1 2.2e-20 72.4 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 AET40132.1 - 1.7e-15 57.2 4.0 1.1e-10 41.8 0.9 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AET40132.1 - 2.5e-12 45.6 3.6 0.001 18.9 0.2 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 AET40132.1 - 2.9e-11 42.1 5.1 0.005 16.3 0.2 4.1 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.6 AET40132.1 - 0.00044 19.6 3.1 0.0072 15.8 0.2 3.2 3 0 0 3 3 3 1 EF hand SPARC_Ca_bdg PF10591.9 AET40132.1 - 0.021 15.1 0.2 0.046 14.0 0.2 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 AET40132.1 - 0.022 14.6 3.4 4.4 7.2 0.1 3.1 2 1 1 3 3 3 0 EF-hand domain pair EF-hand_9 PF14658.6 AET40132.1 - 0.11 12.8 0.1 14 6.1 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain HORMA PF02301.18 AET40133.1 - 9.3e-05 22.1 0.0 0.00016 21.4 0.0 1.4 1 1 0 1 1 1 1 HORMA domain DNA_mis_repair PF01119.19 AET40134.1 - 1e-25 89.7 0.0 4.6e-25 87.6 0.0 2.1 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.11 AET40134.1 - 9.5e-24 83.8 0.0 2.4e-23 82.6 0.0 1.7 1 0 0 1 1 1 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.6 AET40134.1 - 8.8e-14 51.5 0.1 2.7e-13 49.9 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 AET40134.1 - 2.4e-05 24.8 0.2 0.00026 21.5 0.0 2.5 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_S13 PF00416.22 AET40135.1 - 6.2e-19 68.6 0.6 7.8e-17 61.9 0.6 2.2 1 1 0 1 1 1 1 Ribosomal protein S13/S18 IMS_HHH PF11798.8 AET40135.1 - 0.0013 18.9 0.1 0.015 15.6 0.0 2.3 2 0 0 2 2 2 1 IMS family HHH motif CheX PF13690.6 AET40135.1 - 0.056 13.6 0.0 0.075 13.2 0.0 1.3 1 0 0 1 1 1 0 Chemotaxis phosphatase CheX FbpA PF05833.11 AET40135.1 - 0.069 11.9 0.0 0.069 11.9 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) EOS1 PF12326.8 AET40136.1 - 5.7e-63 212.0 7.5 1e-62 211.1 5.5 2.1 2 0 0 2 2 2 1 N-glycosylation protein PLD_C PF12357.8 AET40136.1 - 0.0052 16.7 0.0 0.042 13.8 0.0 2.1 2 0 0 2 2 2 1 Phospholipase D C terminal MLIP PF15274.6 AET40136.1 - 0.12 12.3 0.7 0.23 11.3 0.7 1.4 1 0 0 1 1 1 0 Muscular LMNA-interacting protein Tropomyosin_1 PF12718.7 AET40137.1 - 5.2e-38 130.4 25.1 6.1e-38 130.2 25.1 1.1 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 AET40137.1 - 1.9e-05 24.2 22.6 7.5e-05 22.2 22.6 1.8 1 1 0 1 1 1 1 Tropomyosin CENP-F_leu_zip PF10473.9 AET40137.1 - 0.00011 22.2 4.6 0.00011 22.2 4.6 2.2 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CLZ PF16526.5 AET40137.1 - 0.00019 21.7 18.6 0.015 15.7 0.4 2.6 1 1 1 2 2 2 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TMF_TATA_bd PF12325.8 AET40137.1 - 0.0015 18.7 24.5 0.015 15.5 19.4 2.0 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding DUF1664 PF07889.12 AET40137.1 - 0.0023 18.0 11.6 0.0053 16.8 4.8 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) bZIP_1 PF00170.21 AET40137.1 - 0.003 17.6 23.2 0.44 10.7 0.2 3.6 1 1 1 3 3 3 2 bZIP transcription factor KIP1 PF07765.12 AET40137.1 - 0.0031 17.6 6.1 0.0031 17.6 6.1 2.5 1 1 1 2 2 2 1 KIP1-like protein MscS_porin PF12795.7 AET40137.1 - 0.0035 16.9 21.0 0.0043 16.6 21.0 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain DUF4200 PF13863.6 AET40137.1 - 0.0048 17.3 21.9 0.09 13.2 12.1 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF4200) DUF4201 PF13870.6 AET40137.1 - 0.0062 16.3 17.4 0.0085 15.8 17.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) Spectrin PF00435.21 AET40137.1 - 0.0078 16.7 17.7 0.26 11.8 11.9 2.1 1 1 1 2 2 2 2 Spectrin repeat GAS PF13851.6 AET40137.1 - 0.013 14.8 23.9 0.096 12.0 14.9 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Jnk-SapK_ap_N PF09744.9 AET40137.1 - 0.014 15.7 22.4 0.018 15.3 22.4 1.1 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Spc24 PF08286.11 AET40137.1 - 0.019 15.2 23.3 0.49 10.7 0.1 3.0 1 1 1 2 2 1 0 Spc24 subunit of Ndc80 Mod_r PF07200.13 AET40137.1 - 0.022 14.8 22.9 0.29 11.2 15.9 2.6 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein KLRAQ PF10205.9 AET40137.1 - 0.026 14.7 17.4 0.086 13.1 6.8 2.1 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein ATG16 PF08614.11 AET40137.1 - 0.029 14.6 23.0 0.33 11.1 22.6 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) ADIP PF11559.8 AET40137.1 - 0.029 14.5 20.9 0.18 11.9 1.2 2.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding BLOC1_2 PF10046.9 AET40137.1 - 0.035 14.4 17.4 0.084 13.2 6.6 2.4 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TPR_MLP1_2 PF07926.12 AET40137.1 - 0.038 14.1 24.8 1 9.4 13.9 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.10 AET40137.1 - 0.044 14.0 11.6 0.33 11.1 11.6 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.8 AET40137.1 - 0.044 13.8 29.6 0.09 12.8 6.5 3.1 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding Sec2p PF06428.11 AET40137.1 - 0.047 13.7 23.9 0.27 11.2 6.6 3.4 1 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p FlaC_arch PF05377.11 AET40137.1 - 0.047 14.1 16.8 0.22 12.0 0.2 3.5 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Fzo_mitofusin PF04799.13 AET40137.1 - 0.061 12.9 13.9 0.13 11.8 4.9 2.1 1 1 1 2 2 2 0 fzo-like conserved region APG17 PF04108.12 AET40137.1 - 0.062 12.4 14.7 1.6 7.8 14.6 2.6 1 1 0 1 1 1 0 Autophagy protein Apg17 GrpE PF01025.19 AET40137.1 - 0.063 12.9 20.7 8.1 6.1 9.3 2.4 1 1 1 2 2 2 0 GrpE Spc7 PF08317.11 AET40137.1 - 0.072 12.0 22.4 0.11 11.4 22.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein FliD_C PF07195.12 AET40137.1 - 0.076 12.4 12.3 0.76 9.1 0.1 2.8 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 C-terminus MRPL52 PF18699.1 AET40137.1 - 0.077 13.2 0.3 0.077 13.2 0.3 2.2 1 1 1 2 2 2 0 Mitoribosomal protein mL52 Snapin_Pallidin PF14712.6 AET40137.1 - 0.1 13.0 18.0 0.31 11.5 5.5 2.3 1 1 1 2 2 2 0 Snapin/Pallidin T2SSM PF04612.12 AET40137.1 - 0.11 12.5 4.6 0.19 11.8 2.1 1.9 1 1 0 2 2 2 0 Type II secretion system (T2SS), protein M Prefoldin_2 PF01920.20 AET40137.1 - 0.12 12.4 24.3 1.6 8.8 4.5 3.1 1 1 2 3 3 3 0 Prefoldin subunit Rho_Binding PF08912.11 AET40137.1 - 0.12 13.2 29.0 0.99 10.3 10.6 3.0 1 1 2 3 3 3 0 Rho Binding Arfaptin PF06456.13 AET40137.1 - 0.12 11.9 10.0 0.31 10.6 2.9 2.3 1 1 1 2 2 2 0 Arfaptin-like domain Lectin_N PF03954.14 AET40137.1 - 0.15 11.8 12.6 0.56 10.0 4.9 2.3 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain HCMV_UL139 PF12507.8 AET40137.1 - 0.16 12.3 4.2 0.28 11.6 0.7 2.1 1 1 1 2 2 2 0 Human Cytomegalovirus UL139 protein IZUMO PF15005.6 AET40137.1 - 0.17 12.4 7.7 0.21 12.1 7.7 1.2 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated IFT57 PF10498.9 AET40137.1 - 0.18 10.8 16.6 0.25 10.3 16.6 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Nup54 PF13874.6 AET40137.1 - 0.2 11.8 14.4 0.64 10.1 2.1 2.1 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Ax_dynein_light PF10211.9 AET40137.1 - 0.2 11.6 21.5 0.52 10.2 0.9 2.5 1 1 1 2 2 2 0 Axonemal dynein light chain ZapB PF06005.12 AET40137.1 - 0.22 12.0 28.9 8.8 6.9 20.9 3.0 1 1 1 2 2 2 0 Cell division protein ZapB Fmp27_WPPW PF10359.9 AET40137.1 - 0.23 10.3 13.2 0.31 9.9 13.2 1.3 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain WXG100 PF06013.12 AET40137.1 - 0.25 11.6 7.7 13 6.1 3.5 3.2 2 1 0 2 2 2 0 Proteins of 100 residues with WXG DASH_Spc19 PF08287.11 AET40137.1 - 0.28 11.1 19.8 4.3 7.2 0.1 2.1 1 1 1 2 2 2 0 Spc19 Prominin PF05478.11 AET40137.1 - 0.29 9.0 9.7 0.31 9.0 9.7 1.0 1 0 0 1 1 1 0 Prominin HetR_C PF18460.1 AET40137.1 - 0.31 11.0 3.8 0.42 10.6 0.6 2.4 1 1 2 3 3 3 0 Heterocyst differentiation regulator C-terminal Hood domain OmpH PF03938.14 AET40137.1 - 0.31 11.4 17.7 0.14 12.5 11.1 2.0 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF812 PF05667.11 AET40137.1 - 0.34 9.8 19.9 0.41 9.5 19.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) SOGA PF11365.8 AET40137.1 - 0.35 12.0 18.3 2.3 9.4 17.3 2.3 1 1 0 1 1 1 0 Protein SOGA MCRS_N PF13325.6 AET40137.1 - 0.35 10.9 12.4 0.55 10.2 12.4 1.3 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein LPP PF04728.13 AET40137.1 - 0.44 11.0 6.9 6.5 7.2 0.1 2.9 2 1 0 2 2 2 0 Lipoprotein leucine-zipper DUF724 PF05266.14 AET40137.1 - 0.47 10.3 15.6 0.7 9.7 15.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Laminin_II PF06009.12 AET40137.1 - 0.47 10.5 13.4 2.7 8.0 4.5 2.5 1 1 1 2 2 2 0 Laminin Domain II DHR10 PF18595.1 AET40137.1 - 0.55 10.3 23.4 1.2 9.2 10.6 2.2 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain Swi5 PF07061.11 AET40137.1 - 0.56 10.3 21.5 1.9 8.6 4.9 3.1 1 1 2 3 3 3 0 Swi5 DUF1640 PF07798.11 AET40137.1 - 0.58 10.2 19.4 2.3 8.2 16.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) ERM PF00769.19 AET40137.1 - 0.62 9.8 23.4 1.5 8.6 23.4 1.5 1 1 0 1 1 1 0 Ezrin/radixin/moesin family STAT_alpha PF01017.20 AET40137.1 - 0.69 9.8 16.3 1 9.3 15.7 1.5 1 1 1 2 2 2 0 STAT protein, all-alpha domain KASH_CCD PF14662.6 AET40137.1 - 0.7 9.7 26.2 0.89 9.4 26.2 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH GIDA_assoc PF13932.6 AET40137.1 - 0.75 9.9 8.0 0.92 9.7 8.0 1.1 1 0 0 1 1 1 0 GidA associated domain DUF3450 PF11932.8 AET40137.1 - 0.78 9.0 18.6 2.6 7.3 3.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) KxDL PF10241.9 AET40137.1 - 0.79 10.0 16.9 1.6 9.1 6.4 2.8 1 1 2 3 3 3 0 Uncharacterized conserved protein Seryl_tRNA_N PF02403.22 AET40137.1 - 0.81 9.9 17.8 5.2 7.3 0.3 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Rootletin PF15035.6 AET40137.1 - 0.91 9.5 23.1 5.3 7.0 20.3 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Phage_GP20 PF06810.11 AET40137.1 - 0.93 9.3 19.2 3.3 7.5 18.0 2.0 1 1 0 1 1 1 0 Phage minor structural protein GP20 DivIVA PF05103.13 AET40137.1 - 0.95 9.6 18.8 2 8.5 3.2 3.0 1 1 1 2 2 2 0 DivIVA protein LprI PF07007.12 AET40137.1 - 1.1 10.0 6.9 2 9.1 2.5 2.4 1 1 2 3 3 2 0 Lysozyme inhibitor LprI DUF2203 PF09969.9 AET40137.1 - 1.1 10.0 11.7 4.8 7.9 0.8 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) MPS2 PF17060.5 AET40137.1 - 1.2 8.3 15.5 1.9 7.6 4.4 2.0 1 1 1 2 2 2 0 Monopolar spindle protein 2 RPW8 PF05659.11 AET40137.1 - 1.2 8.8 10.0 4.8 6.9 9.0 2.1 1 1 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF4407 PF14362.6 AET40137.1 - 1.2 8.4 9.9 1.7 7.9 9.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FPP PF05911.11 AET40137.1 - 1.2 7.2 23.4 1.6 6.9 23.4 1.2 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil Tweety PF04906.13 AET40137.1 - 1.3 7.7 5.5 1.1 7.8 4.3 1.4 1 1 0 1 1 1 0 Tweety APG6_N PF17675.1 AET40137.1 - 1.3 9.5 29.8 35 4.9 29.8 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region Exonuc_VII_L PF02601.15 AET40137.1 - 1.3 8.5 10.9 1.5 8.3 10.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF572 PF04502.13 AET40137.1 - 1.4 8.5 16.1 1.5 8.4 16.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) DivIC PF04977.15 AET40137.1 - 1.6 8.6 21.0 2.8 7.8 6.0 3.5 1 1 2 3 3 3 0 Septum formation initiator CorA PF01544.18 AET40137.1 - 1.7 7.9 8.8 2.1 7.6 8.8 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein YabA PF06156.13 AET40137.1 - 1.9 9.2 18.3 15 6.2 13.5 2.3 1 1 1 2 2 2 0 Initiation control protein YabA Cnn_1N PF07989.11 AET40137.1 - 1.9 8.7 21.1 4.2 7.6 15.9 2.6 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 HemX PF04375.14 AET40137.1 - 2 7.6 16.8 14 4.9 16.8 1.9 1 1 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Remorin_C PF03763.13 AET40137.1 - 2.1 8.3 14.7 3.8 7.4 7.9 2.3 1 1 1 2 2 2 0 Remorin, C-terminal region AAA_13 PF13166.6 AET40137.1 - 2.3 6.7 16.2 4.4 5.8 16.2 1.5 1 1 0 1 1 1 0 AAA domain CENP-K PF11802.8 AET40137.1 - 2.5 7.6 21.3 1.4 8.4 9.8 1.9 1 1 1 2 2 2 0 Centromere-associated protein K Arm-DNA-bind_5 PF17293.2 AET40137.1 - 2.8 8.4 9.2 1.7 9.1 4.5 2.1 1 1 1 2 2 2 0 Arm DNA-binding domain bZIP_2 PF07716.15 AET40137.1 - 3 8.0 21.8 3.6 7.8 3.4 3.7 3 2 1 4 4 4 0 Basic region leucine zipper UPF0242 PF06785.11 AET40137.1 - 3.4 7.7 25.3 12 5.9 25.2 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FemAB PF02388.16 AET40137.1 - 3.8 6.3 13.5 4.3 6.1 12.9 1.4 1 1 0 1 1 1 0 FemAB family XhlA PF10779.9 AET40137.1 - 4.6 7.5 15.9 19 5.6 0.1 3.3 1 1 2 3 3 3 0 Haemolysin XhlA FapA PF03961.13 AET40137.1 - 4.7 5.7 18.0 30 3.1 18.0 1.9 1 1 0 1 1 1 0 Flagellar Assembly Protein A ACCA PF03255.14 AET40137.1 - 5.2 6.9 11.7 7.9 6.4 8.5 2.1 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF745 PF05335.13 AET40137.1 - 5.4 6.7 11.4 16 5.2 11.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF745) DUF5595 PF18077.1 AET40137.1 - 5.8 7.1 19.7 0.62 10.2 2.8 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF5595) Herpes_UL6 PF01763.16 AET40137.1 - 6.2 5.2 13.4 21 3.5 13.4 1.9 1 1 0 1 1 1 0 Herpesvirus UL6 like MCU PF04678.13 AET40137.1 - 6.4 6.8 12.3 5.4 7.1 1.8 2.3 1 1 1 2 2 2 0 Mitochondrial calcium uniporter THOC7 PF05615.13 AET40137.1 - 7.4 6.9 18.8 6.8 7.0 7.6 2.3 1 1 1 2 2 2 0 Tho complex subunit 7 Med4 PF10018.9 AET40137.1 - 8.4 6.0 18.4 4.7 6.8 5.3 2.1 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Tho2 PF11262.8 AET40137.1 - 9 5.4 12.0 10 5.2 11.8 1.3 1 1 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF16 PF01519.16 AET40137.1 - 9.1 6.8 15.5 2.8e+03 -1.1 15.5 2.2 1 1 0 1 1 0 0 Protein of unknown function DUF16 DnaJ_C PF01556.18 AET40139.1 - 2.1e-27 96.0 0.0 2.8e-27 95.6 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AET40139.1 - 4.2e-22 78.0 0.7 8.9e-22 77.0 0.7 1.6 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 AET40139.1 - 2.2e-11 43.9 16.6 4.8e-11 42.9 16.6 1.6 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 AET40139.1 - 2.3 8.2 9.8 4.3 7.4 1.0 2.9 2 1 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf-RING_10 PF16685.5 AET40139.1 - 4.3 7.6 6.2 38 4.5 3.7 2.7 1 1 1 2 2 2 0 zinc RING finger of MSL2 HypA PF01155.19 AET40139.1 - 5.1 7.2 6.1 24 5.0 0.5 2.5 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DegS PF05384.11 AET40140.1 - 0.0073 15.8 0.8 0.019 14.5 0.8 1.7 1 0 0 1 1 1 1 Sensor protein DegS Apolipoprotein PF01442.18 AET40140.1 - 0.0097 15.8 7.4 0.064 13.1 7.3 2.2 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain YtxH PF12732.7 AET40140.1 - 0.01 16.4 11.8 2.1 8.9 0.6 4.3 4 0 0 4 4 4 0 YtxH-like protein ZnuA PF01297.17 AET40140.1 - 0.03 13.7 0.2 0.048 13.1 0.2 1.3 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic Rogdi_lz PF10259.9 AET40140.1 - 0.083 12.3 0.1 0.13 11.7 0.1 1.3 1 0 0 1 1 1 0 Rogdi leucine zipper containing protein Sec8_exocyst PF04048.14 AET40140.1 - 0.096 12.6 2.1 0.16 11.8 0.5 2.1 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain DUF2508 PF10704.9 AET40140.1 - 0.11 12.7 1.4 0.27 11.4 1.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2508) DUF883 PF05957.13 AET40140.1 - 0.51 11.0 9.8 1.6 9.4 1.9 3.4 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) Exonuc_VII_L PF02601.15 AET40140.1 - 0.57 9.7 8.2 1.1 8.8 8.2 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit Phasin PF05597.11 AET40140.1 - 2 8.4 6.7 3.5 7.7 0.5 2.7 3 0 0 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Rotamase PF00639.21 AET40140.1 - 2.8 9.0 7.7 1 10.4 0.6 3.0 1 1 1 2 2 2 0 PPIC-type PPIASE domain DUF1451 PF07295.11 AET40140.1 - 4.9 7.2 6.6 4.3 7.4 2.4 2.7 2 1 1 3 3 3 0 Zinc-ribbon containing domain DUF1752 PF08550.10 AET40141.1 - 5.5e-10 38.9 0.3 1.9e-09 37.2 0.3 2.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Brix PF04427.18 AET40142.1 - 1e-30 107.3 0.4 1.3e-30 106.9 0.4 1.1 1 0 0 1 1 1 1 Brix domain CTU2 PF10288.9 AET40143.1 - 0.042 14.1 1.6 0.14 12.4 0.2 2.3 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 SUIM_assoc PF16619.5 AET40143.1 - 0.25 11.5 9.6 0.26 11.4 0.5 2.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Med3 PF11593.8 AET40143.1 - 1.2 8.2 14.1 0.55 9.4 0.5 2.5 1 1 1 2 2 2 0 Mediator complex subunit 3 fungal tRNA-synt_2 PF00152.20 AET40144.1 - 2.4e-61 207.6 0.0 3.2e-61 207.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AET40144.1 - 9.5e-07 28.7 0.0 1.8e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 AET40144.1 - 1.4e-06 27.9 0.2 0.00025 20.6 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) RNase_HII PF01351.18 AET40145.1 - 5.9e-65 218.8 0.0 7.3e-65 218.5 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII 2-oxoacid_dh PF00198.23 AET40146.1 - 8.9e-76 254.4 0.1 1.1e-75 254.0 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 AET40146.1 - 5.3e-17 61.4 0.1 1e-16 60.5 0.1 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 AET40146.1 - 1.2e-14 54.4 0.2 1.2e-14 54.4 0.2 3.1 3 0 0 3 3 3 1 e3 binding domain Tom7 PF08038.12 AET40147.1 - 5.5e-18 64.3 0.0 7.7e-18 63.9 0.0 1.2 1 0 0 1 1 1 1 TOM7 family Mito_carr PF00153.27 AET40148.1 - 1.4e-57 191.6 2.5 4.4e-20 71.4 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L13 PF00572.18 AET40149.1 - 7e-12 45.7 1.0 1.2e-08 35.3 0.0 2.5 2 1 1 3 3 3 2 Ribosomal protein L13 CSM2 PF16834.5 AET40150.1 - 3.5e-62 209.6 0.0 4.1e-62 209.4 0.0 1.0 1 0 0 1 1 1 1 Shu complex component Csm2, DNA-binding Forkhead PF00250.18 AET40151.1 - 9.4e-34 115.5 1.0 4.4e-33 113.4 0.1 2.3 2 0 0 2 2 2 1 Forkhead domain FHA PF00498.26 AET40151.1 - 8.1e-13 48.5 0.5 2.6e-12 46.9 0.1 2.2 2 0 0 2 2 2 1 FHA domain Linker_histone PF00538.19 AET40151.1 - 0.00043 20.6 0.0 0.001 19.4 0.0 1.6 1 0 0 1 1 1 1 linker histone H1 and H5 family Fungal_trans PF04082.18 AET40152.1 - 1.4e-26 93.1 2.0 1.9e-26 92.7 0.8 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET40152.1 - 9.7e-11 41.6 12.3 1.9e-10 40.7 12.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Presenilin PF01080.17 AET40153.1 - 0.032 13.0 7.5 0.057 12.2 7.5 1.4 1 0 0 1 1 1 0 Presenilin SelP_N PF04592.14 AET40153.1 - 0.1 12.0 21.5 0.26 10.7 21.5 1.7 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Tim54 PF11711.8 AET40153.1 - 0.39 9.5 8.9 0.63 8.8 8.9 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 AET40153.1 - 0.91 8.7 6.0 1.5 7.9 6.0 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter RR_TM4-6 PF06459.12 AET40153.1 - 1.6 8.5 7.8 2.8 7.7 7.8 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CPSF100_C PF13299.6 AET40153.1 - 1.9 8.7 4.5 6.2 7.0 4.5 1.9 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Neur_chan_memb PF02932.16 AET40153.1 - 1.9 8.5 13.1 0.87 9.6 10.1 1.8 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Connexin PF00029.19 AET40153.1 - 2.2 8.0 4.5 3.6 7.3 4.5 1.3 1 0 0 1 1 1 0 Connexin eIF-3_zeta PF05091.12 AET40153.1 - 4.2 6.2 11.4 6.9 5.5 11.4 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CobT PF06213.12 AET40153.1 - 5.4 6.3 13.4 12 5.2 13.4 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT ANAPC_CDC26 PF10471.9 AET40153.1 - 6.3 7.7 0.0 6.3 7.7 0.0 3.6 3 1 1 4 4 3 0 Anaphase-promoting complex APC subunit CDC26 Hid1 PF12722.7 AET40153.1 - 9.4 4.2 11.9 16 3.5 11.9 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SUN PF03856.13 AET40154.1 - 1.1e-94 316.5 7.5 1.5e-94 316.0 7.5 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) Zip PF02535.22 AET40154.1 - 0.13 11.4 0.5 0.25 10.5 0.5 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter PRCC PF10253.9 AET40154.1 - 0.35 11.6 14.4 0.55 11.0 14.4 1.4 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Apt1 PF10351.9 AET40154.1 - 0.43 9.4 11.2 0.63 8.8 11.2 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain adh_short PF00106.25 AET40155.1 - 3.1e-44 150.8 0.7 4.2e-44 150.3 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AET40155.1 - 6.2e-27 94.7 0.0 7.8e-27 94.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AET40155.1 - 8.5e-11 42.1 0.1 1.2e-10 41.5 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AET40155.1 - 5.5e-07 29.3 0.1 1.1e-06 28.3 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 AET40155.1 - 9.7e-05 21.9 0.1 0.00076 18.9 0.1 2.3 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 AET40155.1 - 0.032 14.1 0.1 0.08 12.8 0.0 1.6 2 0 0 2 2 2 0 NAD(P)H-binding RmlD_sub_bind PF04321.17 AET40155.1 - 0.098 11.7 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain Transket_pyr PF02779.24 AET40156.1 - 3.5e-63 212.5 0.0 5.4e-63 211.9 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 AET40156.1 - 2.5e-58 197.4 0.0 3.3e-58 197.0 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 AET40156.1 - 1.3e-47 161.3 0.0 2.1e-47 160.6 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 AET40156.1 - 1.4e-18 66.1 1.1 1.4e-18 66.1 1.1 2.0 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus Ribosomal_L6 PF00347.23 AET40157.1 - 5.8e-30 103.8 9.6 1.2e-15 57.9 3.7 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 NPHI_C PF08469.10 AET40157.1 - 0.037 14.0 0.7 0.15 12.1 0.3 2.0 1 1 1 2 2 2 0 Nucleoside triphosphatase I C-terminal YbbR PF07949.12 AET40157.1 - 0.097 13.0 2.9 0.73 10.2 0.1 2.9 1 1 2 3 3 3 0 YbbR-like protein SLS PF14611.6 AET40157.1 - 0.11 12.3 0.4 0.15 11.8 0.4 1.5 1 1 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator SNF2_N PF00176.23 AET40158.1 - 6.3e-76 255.4 0.7 1.6e-75 254.0 0.7 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AET40158.1 - 1.3e-23 83.4 1.7 4.7e-19 68.8 0.0 3.7 3 0 0 3 3 3 2 Helicase conserved C-terminal domain Bromodomain PF00439.25 AET40158.1 - 1.6e-17 63.4 0.6 4.4e-17 61.9 0.6 1.8 1 0 0 1 1 1 1 Bromodomain HSA PF07529.13 AET40158.1 - 9.1e-12 45.1 11.9 9.1e-12 45.1 11.9 2.9 2 0 0 2 2 2 1 HSA ResIII PF04851.15 AET40158.1 - 1e-09 38.6 0.1 1e-09 38.6 0.1 2.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SnAC PF14619.6 AET40158.1 - 4.6e-08 33.5 0.2 4.6e-08 33.5 0.2 4.4 5 1 1 6 6 6 1 Snf2-ATP coupling, chromatin remodelling complex DEAD PF00270.29 AET40158.1 - 2e-05 24.4 0.1 0.00013 21.8 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase QLQ PF08880.11 AET40158.1 - 0.032 14.0 0.0 0.12 12.2 0.0 2.0 1 0 0 1 1 1 0 QLQ RRT14 PF17075.5 AET40159.1 - 2e-26 93.4 0.0 2.4e-26 93.1 0.0 1.0 1 0 0 1 1 1 1 Regular of rDNA transcription protein 14 DUF1003 PF06210.11 AET40159.1 - 1.6 8.9 8.5 3.2 7.9 8.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) MMS19_C PF12460.8 AET40160.1 - 2.9e-92 310.0 23.6 2.9e-92 310.0 23.6 2.6 3 1 0 3 3 3 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 AET40160.1 - 2.4e-80 269.9 10.9 3e-79 266.3 1.5 3.6 4 0 0 4 4 4 2 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_EZ PF13513.6 AET40160.1 - 0.0036 17.8 3.2 7.1 7.2 0.4 4.7 3 1 2 5 5 5 2 HEAT-like repeat RTP1_C1 PF10363.9 AET40160.1 - 0.0083 16.3 8.4 0.14 12.3 0.4 3.8 4 0 0 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 AET40160.1 - 0.047 14.0 0.6 24 5.5 0.1 4.7 5 0 0 5 5 5 0 HEAT repeat Epsilon_antitox PF08998.11 AET40160.1 - 0.093 13.0 2.5 1.7 9.0 0.8 3.3 2 0 0 2 2 2 0 Bacterial epsilon antitoxin PIN7 PF18475.1 AET40160.1 - 0.2 12.3 1.7 0.57 10.8 0.2 2.5 3 0 0 3 3 3 0 PIN domain Telomere_reg-2 PF10193.9 AET40160.1 - 0.28 11.7 10.3 0.34 11.4 0.7 4.3 4 0 0 4 4 4 0 Telomere length regulation protein Ipi1_N PF12333.8 AET40160.1 - 0.71 10.5 4.0 10 6.8 0.0 4.2 4 0 0 4 4 4 0 Rix1 complex component involved in 60S ribosome maturation Cnd1 PF12717.7 AET40160.1 - 0.99 9.4 15.4 0.33 11.0 0.5 4.4 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 VHS PF00790.19 AET40160.1 - 3.3 7.6 8.4 4 7.3 0.0 4.4 6 0 0 6 6 6 0 VHS domain Aa_trans PF01490.18 AET40162.1 - 1.3e-94 317.2 40.2 1.6e-94 317.0 40.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 AET40162.1 - 6.5e-06 25.2 46.4 2.2e-05 23.5 46.4 1.6 1 1 0 1 1 1 1 Amino acid permease DNA_pol_B PF00136.21 AET40163.1 - 1e-117 393.7 4.5 2.1e-117 392.7 4.5 1.5 1 1 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 AET40163.1 - 4.4e-65 218.9 3.8 8.8e-65 217.9 3.8 1.6 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 AET40163.1 - 2.3e-39 135.5 0.1 6.4e-39 134.0 0.0 1.8 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 AET40163.1 - 6.3e-18 64.6 2.3 2.3e-17 62.8 2.3 2.1 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal zinc_ribbon_4 PF13717.6 AET40163.1 - 0.31 11.0 1.8 22 5.1 0.1 2.7 2 0 0 2 2 2 0 zinc-ribbon domain SNARE PF05739.19 AET40164.1 - 7.7e-11 41.8 2.6 2.5e-10 40.2 2.6 2.0 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 AET40164.1 - 0.00011 22.6 26.1 0.0041 17.5 6.2 3.3 2 2 1 3 3 3 2 Syntaxin-like protein Synaptobrevin PF00957.21 AET40164.1 - 0.00013 21.6 3.4 0.00013 21.6 3.4 2.1 2 0 0 2 2 2 1 Synaptobrevin Occludin_ELL PF07303.13 AET40164.1 - 0.0059 17.3 0.3 0.0059 17.3 0.3 3.0 1 1 2 3 3 3 1 Occludin homology domain Prominin PF05478.11 AET40164.1 - 0.018 13.0 15.1 0.025 12.6 15.1 1.2 1 0 0 1 1 1 0 Prominin Noelin-1 PF12308.8 AET40164.1 - 0.029 14.3 8.4 0.47 10.5 3.4 2.6 2 0 0 2 2 2 0 Neurogenesis glycoprotein Rx_N PF18052.1 AET40164.1 - 0.03 14.6 2.0 0.05 13.9 0.1 2.4 2 1 1 3 3 3 0 Rx N-terminal domain DUF5345 PF17280.2 AET40164.1 - 0.056 13.4 2.5 0.16 12.0 0.0 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5345) PHtD_u1 PF16645.5 AET40164.1 - 0.068 13.6 2.4 2.2 8.8 0.8 2.8 2 0 0 2 2 2 0 Unstructured region on Pneumococcal histidine triad protein T2SSF PF00482.23 AET40164.1 - 0.071 13.1 0.1 1.9 8.5 0.0 2.5 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein F DUF2207 PF09972.9 AET40164.1 - 0.15 10.8 1.6 0.17 10.6 0.1 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Laminin_II PF06009.12 AET40164.1 - 0.54 10.3 13.1 0.048 13.7 6.4 2.4 2 1 1 3 3 3 0 Laminin Domain II DUF4988 PF16378.5 AET40164.1 - 0.76 9.4 5.6 0.26 10.9 1.3 2.1 2 0 0 2 2 2 0 Domain of unknown function MCU PF04678.13 AET40164.1 - 1.4 9.0 6.1 0.15 12.2 0.8 1.9 2 1 0 2 2 2 0 Mitochondrial calcium uniporter DUF1664 PF07889.12 AET40164.1 - 9.7 6.3 9.0 2.1 8.4 3.7 2.6 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) bZIP_2 PF07716.15 AET40165.1 - 6.4e-06 26.2 0.8 6.4e-06 26.2 0.8 2.0 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 AET40165.1 - 0.002 18.2 3.6 0.0047 17.0 3.6 1.6 1 0 0 1 1 1 1 bZIP transcription factor PspB PF06667.12 AET40165.1 - 0.3 11.2 2.3 0.75 9.9 2.3 1.6 1 0 0 1 1 1 0 Phage shock protein B RGS PF00615.19 AET40166.1 - 5.2e-15 55.7 0.4 1.4e-14 54.4 0.4 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF3091 PF11291.8 AET40166.1 - 0.063 13.5 0.6 0.17 12.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3091) DUF1579 PF07617.11 AET40166.1 - 0.15 11.9 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1579) HMGL-like PF00682.19 AET40167.1 - 1.2e-87 293.9 0.0 1.7e-87 293.3 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 AET40167.1 - 6.3e-26 90.8 1.1 1.5e-25 89.6 0.3 2.0 2 0 0 2 2 2 1 LeuA allosteric (dimerisation) domain Syja_N PF02383.18 AET40168.1 - 4.4e-76 256.2 0.2 8.4e-76 255.3 0.2 1.5 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 AET40168.1 - 3e-13 49.8 0.0 4.8e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family YEATS PF03366.16 AET40170.1 - 5.1e-35 119.3 1.5 8.5e-35 118.6 1.5 1.4 1 0 0 1 1 1 1 YEATS family THOC7 PF05615.13 AET40170.1 - 0.02 15.2 1.1 0.091 13.0 0.6 1.9 2 0 0 2 2 2 0 Tho complex subunit 7 Phage-A118_gp45 PF10653.9 AET40170.1 - 0.097 12.7 0.2 22 5.2 0.0 2.6 2 0 0 2 2 2 0 Protein gp45 of Bacteriophage A118 TFIIIC_sub6 PF10419.9 AET40171.1 - 2.8e-24 84.8 0.3 4.4e-24 84.2 0.3 1.3 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain His_Phos_1 PF00300.22 AET40171.1 - 9.9e-20 71.1 0.0 1.9e-19 70.2 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Maf PF02545.14 AET40172.1 - 1.4e-35 122.6 0.0 1.7e-35 122.3 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein PGM_PMM_II PF02879.16 AET40172.1 - 0.16 12.6 0.0 0.32 11.6 0.0 1.5 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II RRM_1 PF00076.22 AET40173.1 - 7.9e-18 64.1 0.4 2.8e-17 62.3 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 AET40173.1 - 0.06 13.3 0.4 0.19 11.7 0.1 2.1 2 1 0 2 2 2 0 RL domain Cyt-b5 PF00173.28 AET40174.1 - 2.1e-22 79.0 0.1 2.9e-22 78.6 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain CLASP_N PF12348.8 AET40175.1 - 0.016 14.8 0.1 0.087 12.4 0.1 2.2 1 1 0 1 1 1 0 CLASP N terminal DFF-C PF09033.10 AET40175.1 - 0.059 13.3 0.1 0.16 11.8 0.1 1.7 1 0 0 1 1 1 0 DNA Fragmentation factor 45kDa, C terminal domain PGAP1 PF07819.13 AET40175.1 - 0.079 12.7 0.1 0.39 10.4 0.1 2.1 1 1 1 2 2 2 0 PGAP1-like protein DEAD PF00270.29 AET40176.1 - 3.1e-49 167.1 0.0 1.2e-48 165.2 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET40176.1 - 1.3e-32 112.5 0.0 3e-31 108.0 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET40176.1 - 0.00018 21.6 0.0 0.00033 20.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF5335 PF17269.2 AET40176.1 - 0.039 13.8 0.1 0.083 12.7 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5335) AAA_19 PF13245.6 AET40176.1 - 0.15 12.4 0.0 19 5.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain UTP25 PF06862.12 AET40176.1 - 0.21 10.3 0.1 4.9 5.8 0.0 2.5 3 0 0 3 3 3 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 RNA_pol_L_2 PF13656.6 AET40177.1 - 4.3e-34 116.1 0.0 5.6e-34 115.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 AET40177.1 - 2.5e-16 58.9 0.0 3.5e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain zf-C2H2 PF00096.26 AET40178.1 - 8.2e-23 79.5 30.2 1.4e-06 28.4 0.4 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AET40178.1 - 1.5e-22 79.0 28.3 4.9e-09 36.2 0.8 4.5 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 AET40178.1 - 5e-14 51.8 26.2 0.0004 21.0 0.2 4.7 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 AET40178.1 - 0.0016 18.4 28.0 0.016 15.2 0.6 4.4 4 0 0 4 4 4 2 C2H2-type zinc finger zf-Di19 PF05605.12 AET40178.1 - 0.042 14.1 10.6 0.16 12.3 0.6 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 AET40178.1 - 0.071 13.5 15.4 9.3 6.8 0.1 4.6 4 0 0 4 4 4 0 Zinc-finger of C2H2 type DZR PF12773.7 AET40178.1 - 0.53 10.3 6.5 3.4 7.8 6.6 2.1 1 1 1 2 2 2 0 Double zinc ribbon zf-C2H2_2 PF12756.7 AET40178.1 - 3.6 8.0 17.1 23 5.4 3.2 3.6 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf_UBZ PF18439.1 AET40178.1 - 8.4 6.1 11.9 2.2 7.9 0.0 3.8 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger TRAPP PF04051.16 AET40179.1 - 1.4e-34 118.9 0.1 1.9e-34 118.5 0.1 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component SH3_9 PF14604.6 AET40180.1 - 5.5e-26 90.2 0.1 2.2e-13 49.8 0.1 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 AET40180.1 - 3.3e-25 87.4 0.1 4.3e-12 45.4 0.0 2.8 3 0 0 3 3 3 2 SH3 domain FCH PF00611.23 AET40180.1 - 1e-19 70.6 3.0 3.5e-19 68.9 0.3 2.8 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.17 AET40180.1 - 5.1e-17 61.3 0.6 4.4e-10 39.1 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.11 AET40180.1 - 0.001 19.3 0.6 0.029 14.7 0.1 2.4 2 0 0 2 2 2 1 Bacterial SH3 domain DUF2417 PF10329.9 AET40181.1 - 4.4e-59 199.8 10.1 5.9e-59 199.3 10.1 1.1 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Abhydrolase_1 PF00561.20 AET40181.1 - 1.9e-14 53.9 0.1 5.8e-14 52.4 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AET40181.1 - 5.9e-09 36.9 0.0 9.5e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AET40181.1 - 0.0015 17.8 0.0 0.0022 17.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 AET40181.1 - 0.0096 15.7 0.0 0.023 14.5 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2569 PF10754.9 AET40181.1 - 2.3 8.7 10.8 0.17 12.3 5.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) FHA PF00498.26 AET40182.1 - 2.2e-15 56.8 0.0 4.3e-15 55.8 0.0 1.6 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 AET40182.1 - 6.5e-11 41.8 11.6 1.2e-10 40.9 11.6 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 AET40182.1 - 1.1e-06 28.8 14.2 1.8e-06 28.1 14.2 1.3 1 0 0 1 1 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 AET40182.1 - 5e-05 23.5 0.0 0.00014 22.1 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-ANAPC11 PF12861.7 AET40182.1 - 0.0044 17.0 5.6 0.0087 16.1 5.6 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 AET40182.1 - 0.0047 16.9 12.1 0.0077 16.2 12.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 AET40182.1 - 0.0073 16.2 14.4 0.012 15.4 14.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 AET40182.1 - 0.0075 16.5 9.9 0.016 15.5 9.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain Sec_GG PF07549.14 AET40182.1 - 0.083 12.4 0.2 0.15 11.5 0.2 1.5 1 0 0 1 1 1 0 SecD/SecF GG Motif zf-C3HC4_2 PF13923.6 AET40182.1 - 0.084 12.7 13.7 0.14 12.0 13.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AET40182.1 - 0.55 10.3 12.4 1.1 9.4 12.4 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Malate_synthase PF01274.22 AET40183.1 - 8.8e-218 723.8 0.0 1.1e-217 723.6 0.0 1.0 1 0 0 1 1 1 1 Malate synthase HpcH_HpaI PF03328.14 AET40183.1 - 0.015 14.4 0.0 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family RNA_pol_Rpb4 PF03874.16 AET40184.1 - 4.2e-32 111.1 1.9 4.8e-32 110.9 1.9 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb4 CENP-K PF11802.8 AET40184.1 - 0.13 11.8 3.9 0.43 10.1 0.7 2.0 1 1 1 2 2 2 0 Centromere-associated protein K AF0941-like PF14591.6 AET40184.1 - 0.15 12.6 1.1 9.3 6.9 0.2 2.1 2 0 0 2 2 2 0 AF0941-like Glyco_hydro_16 PF00722.21 AET40185.1 - 3.6e-46 156.9 2.1 3.6e-46 156.9 2.1 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 CDC45 PF02724.14 AET40185.1 - 0.19 10.0 0.4 0.2 9.9 0.4 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 AET40185.1 - 0.44 9.9 5.3 0.54 9.6 5.3 1.1 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 AET40185.1 - 1.6 8.0 7.5 2 7.6 7.5 1.1 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 AET40185.1 - 8.2 4.5 8.8 11 4.1 8.8 1.1 1 0 0 1 1 1 0 Nop14-like family JIP_LZII PF16471.5 AET40186.1 - 1.2 9.3 13.0 2.1 8.6 1.0 3.7 3 1 1 4 4 4 0 JNK-interacting protein leucine zipper II Lectin_N PF03954.14 AET40187.1 - 0.024 14.4 0.9 0.024 14.4 0.9 2.8 3 1 0 3 3 3 0 Hepatic lectin, N-terminal domain KASH_CCD PF14662.6 AET40187.1 - 0.042 13.7 3.2 0.08 12.8 3.2 1.4 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Lebercilin PF15619.6 AET40187.1 - 0.064 12.9 3.5 0.13 12.0 3.5 1.4 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Nup54 PF13874.6 AET40187.1 - 0.13 12.3 1.2 0.52 10.4 1.6 1.7 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 YojJ PF10372.9 AET40187.1 - 0.15 12.1 1.0 1.8 8.7 0.1 2.6 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus CENP-F_leu_zip PF10473.9 AET40187.1 - 0.26 11.3 4.0 0.23 11.5 1.8 1.9 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 AET40187.1 - 0.28 11.2 1.5 0.81 9.7 1.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) LPP PF04728.13 AET40187.1 - 3.7 8.0 6.6 6 7.3 0.5 3.4 4 0 0 4 4 4 0 Lipoprotein leucine-zipper V_ATPase_I PF01496.19 AET40188.1 - 3.2e-296 984.6 9.4 3.7e-296 984.4 9.4 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Streptin-Immun PF11083.8 AET40188.1 - 0.032 14.6 1.1 2.3 8.7 0.1 2.9 3 0 0 3 3 3 0 Lantibiotic streptin immunity protein BLOC1_2 PF10046.9 AET40188.1 - 0.034 14.4 0.4 6.3 7.2 0.0 3.0 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Sec8_exocyst PF04048.14 AET40188.1 - 0.049 13.5 1.0 1.5 8.7 0.1 3.1 2 1 0 3 3 3 0 Sec8 exocyst complex component specific domain DASH_Dad4 PF08650.10 AET40188.1 - 0.16 12.0 0.0 1.7 8.7 0.0 2.5 2 0 0 2 2 2 0 DASH complex subunit Dad4 Helo_like_N PF17111.5 AET40188.1 - 0.78 9.1 3.9 6.1 6.2 0.0 2.7 3 0 0 3 3 3 0 Fungal N-terminal domain of STAND proteins HSP70 PF00012.20 AET40189.1 - 2.9e-45 154.6 0.2 5.6e-45 153.6 0.2 1.4 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AET40189.1 - 0.0026 16.6 0.1 0.04 12.7 0.2 2.1 2 0 0 2 2 2 1 MreB/Mbl protein DUF3896 PF13035.6 AET40189.1 - 0.024 14.8 2.3 0.14 12.4 2.3 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3896) ParcG PF10274.9 AET40189.1 - 0.05 13.7 0.4 0.22 11.6 0.0 2.3 3 0 0 3 3 3 0 Parkin co-regulated protein DIL PF01843.19 AET40190.1 - 9.5e-20 70.8 6.3 8.5e-19 67.8 3.6 3.2 2 1 0 2 2 2 1 DIL domain Ank_5 PF13857.6 AET40190.1 - 0.011 16.0 0.2 0.023 15.0 0.2 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) PRMT5_C PF17286.2 AET40191.1 - 2.8e-64 216.2 0.1 5.6e-64 215.3 0.1 1.5 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5_TIM PF17285.2 AET40191.1 - 1.1e-63 214.9 0.1 1.7e-63 214.2 0.1 1.3 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 AET40191.1 - 4.2e-61 205.8 0.1 7.3e-61 205.0 0.1 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase CKS PF01111.19 AET40192.1 - 8.1e-34 115.7 0.1 1.3e-33 115.1 0.1 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit eIF-1a PF01176.19 AET40192.1 - 0.18 11.6 0.0 0.98 9.3 0.0 1.9 2 0 0 2 2 2 0 Translation initiation factor 1A / IF-1 MMM1 PF10296.9 AET40193.1 - 4e-10 39.3 0.6 1e-09 38.0 0.6 1.7 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 PH_11 PF15413.6 AET40193.1 - 3.2e-05 24.3 0.0 9.5e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 AET40193.1 - 4e-05 24.1 0.5 0.00018 22.0 0.1 2.5 2 0 0 2 2 2 1 PH domain Cofilin_ADF PF00241.20 AET40195.1 - 1.2e-25 89.6 0.1 6e-15 55.1 0.1 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein DUF2340 PF10209.9 AET40195.1 - 0.04 14.4 0.1 0.078 13.4 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2340) zf-RING_2 PF13639.6 AET40196.1 - 4e-11 43.1 31.2 5.7e-11 42.6 8.5 2.8 3 0 0 3 3 3 2 Ring finger domain zf-C3HC4 PF00097.25 AET40196.1 - 2.1e-08 33.9 6.5 2.1e-08 33.9 6.5 3.0 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 AET40196.1 - 3.4e-07 30.4 6.8 3.4e-07 30.4 6.8 3.3 3 1 0 3 3 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 AET40196.1 - 7.6e-07 28.9 6.4 7.6e-07 28.9 6.4 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 AET40196.1 - 1.1e-06 28.3 3.6 1.1e-06 28.3 3.6 2.9 2 1 0 2 2 1 1 RING-like zinc finger zf-ANAPC11 PF12861.7 AET40196.1 - 5.4e-06 26.4 2.7 5.4e-06 26.4 2.7 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 AET40196.1 - 0.00021 21.2 6.7 0.00021 21.2 6.7 2.7 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 AET40196.1 - 0.0014 18.7 4.9 0.0014 18.7 4.9 2.6 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 AET40196.1 - 0.002 18.0 4.5 0.002 18.0 4.5 3.5 2 1 1 3 3 2 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 AET40196.1 - 0.0021 17.6 6.1 0.0021 17.6 6.1 3.0 2 2 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 AET40196.1 - 0.005 16.6 5.4 0.005 16.6 5.4 3.1 2 1 0 2 2 2 1 RING/Ubox like zinc-binding domain Zf_RING PF16744.5 AET40196.1 - 0.054 13.6 19.2 0.048 13.8 9.1 3.3 2 2 0 2 2 2 0 KIAA1045 RING finger FANCL_C PF11793.8 AET40196.1 - 1.9 8.8 27.0 0.78 10.0 7.2 3.2 3 1 0 3 3 2 0 FANCL C-terminal domain PHF5 PF03660.14 AET40197.1 - 1.8e-50 169.4 10.8 2.1e-50 169.3 10.8 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 AET40197.1 - 3.4 5.4 9.4 3.7 5.3 9.4 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Sec7 PF01369.20 AET40198.1 - 6.4e-27 94.4 6.2 1.2e-26 93.6 6.2 1.4 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 AET40198.1 - 0.00021 21.7 0.1 0.00063 20.2 0.1 1.9 1 1 0 1 1 1 1 PH domain PH_13 PF16652.5 AET40198.1 - 0.037 13.8 0.0 0.15 11.9 0.0 2.0 1 0 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.6 AET40198.1 - 0.043 14.2 0.1 0.36 11.2 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain ISN1 PF06437.11 AET40200.1 - 2.7e-168 560.2 0.0 3.7e-168 559.7 0.0 1.2 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase Choline_transpo PF04515.12 AET40201.1 - 3.1e-81 273.1 21.6 3.1e-81 273.1 21.6 2.4 2 1 0 2 2 2 1 Plasma-membrane choline transporter Xpo1 PF08389.12 AET40203.1 - 2.2e-27 96.0 7.7 3.7e-27 95.2 1.6 4.1 4 0 0 4 4 4 1 Exportin 1-like protein IBN_N PF03810.19 AET40203.1 - 6.5e-07 29.2 0.9 4.3e-06 26.5 0.3 2.8 1 1 1 2 2 2 1 Importin-beta N-terminal domain zf-Sec23_Sec24 PF04810.15 AET40203.1 - 0.056 13.5 1.2 0.24 11.5 0.2 2.5 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger HEAT PF02985.22 AET40203.1 - 0.078 13.3 0.2 8 7.0 0.0 4.1 4 0 0 4 4 4 0 HEAT repeat DUF285 PF03382.14 AET40203.1 - 0.13 12.0 0.4 0.41 10.4 0.4 1.9 1 0 0 1 1 1 0 Mycoplasma protein of unknown function, DUF285 RNA_POL_M_15KD PF02150.16 AET40203.1 - 1.1 9.2 6.1 4 7.4 0.1 3.0 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit LSM PF01423.22 AET40204.1 - 1.8e-13 49.9 0.0 2.1e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 AET40204.1 - 0.027 14.1 0.1 0.044 13.4 0.1 1.4 1 0 0 1 1 1 0 Hfq protein MRP-S26 PF14943.6 AET40205.1 - 0.27 11.1 15.6 0.051 13.5 5.2 2.4 1 1 1 2 2 2 0 Mitochondrial ribosome subunit S26 LMBR1 PF04791.16 AET40205.1 - 2.2 7.1 3.8 3.5 6.4 3.8 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein TRAPPC9-Trs120 PF08626.11 AET40206.1 - 7.9e-296 984.1 17.8 9.4e-296 983.9 17.8 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TPR_12 PF13424.6 AET40206.1 - 0.025 14.9 0.2 0.064 13.6 0.2 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Pneumo_M2 PF07380.11 AET40206.1 - 0.059 13.7 0.2 5.2 7.4 0.0 2.8 2 0 0 2 2 2 0 Pneumovirus M2 protein Proteasome PF00227.26 AET40207.1 - 7.6e-48 162.5 0.1 1e-47 162.1 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 AET40207.1 - 4.9e-12 45.0 0.1 4.9e-12 45.0 0.1 1.7 2 0 0 2 2 2 1 Proteasome beta subunits C terminal Formyl_trans_N PF00551.19 AET40208.1 - 2.4e-49 167.5 0.0 2.8e-49 167.3 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase PINIT PF14324.6 AET40209.1 - 2.1e-34 118.9 0.0 6.7e-34 117.3 0.0 1.9 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 AET40209.1 - 9.8e-19 66.8 5.8 1.7e-18 66.1 5.8 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.27 AET40209.1 - 1.2e-12 47.3 0.0 2.1e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 SAP domain zf-Nse PF11789.8 AET40209.1 - 2.9e-07 30.2 3.3 7.9e-07 28.8 3.3 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 AET40209.1 - 0.032 14.2 1.9 0.048 13.7 0.6 2.0 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 AET40209.1 - 0.16 11.9 2.7 0.29 11.0 2.7 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AET40209.1 - 0.29 11.0 6.2 0.35 10.7 5.0 1.8 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AET40209.1 - 0.76 9.7 3.7 1.6 8.7 3.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 AET40209.1 - 0.91 9.7 5.0 1.8 8.8 5.0 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING ICMT PF04140.14 AET40210.1 - 3.1e-30 104.4 0.3 3.1e-30 104.4 0.3 1.9 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 AET40210.1 - 1.3e-11 44.8 1.9 1.3e-11 44.8 1.9 2.2 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 AET40210.1 - 1.8e-06 27.7 2.3 2.6e-06 27.2 2.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) NnrU PF07298.11 AET40210.1 - 0.011 15.3 1.1 0.02 14.4 1.1 1.6 1 1 0 1 1 1 0 NnrU protein zf-HIT PF04438.16 AET40211.1 - 0.0016 18.2 12.1 0.0033 17.2 12.1 1.5 1 0 0 1 1 1 1 HIT zinc finger PB1-F2 PF11986.8 AET40211.1 - 0.031 14.5 0.0 0.068 13.4 0.0 1.6 1 0 0 1 1 1 0 Influenza A Proapoptotic protein Carn_acyltransf PF00755.20 AET40212.1 - 2.5e-176 587.8 0.0 2.9e-176 587.6 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Thioredoxin PF00085.20 AET40213.1 - 3.1e-25 88.1 0.0 5.6e-25 87.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin DER1 PF04511.15 AET40213.1 - 6.8e-18 65.3 17.3 1e-17 64.7 17.3 1.2 1 0 0 1 1 1 1 Der1-like family Thioredoxin_2 PF13098.6 AET40213.1 - 6.1e-05 23.4 0.3 0.00064 20.1 0.3 2.3 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 AET40213.1 - 7.9e-05 22.9 0.1 0.0076 16.6 0.0 2.4 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_9 PF14595.6 AET40213.1 - 0.00047 19.9 0.0 0.00076 19.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 AET40213.1 - 0.0017 18.3 0.0 0.01 15.8 0.0 2.1 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 AET40213.1 - 0.097 12.4 0.0 0.27 10.9 0.0 1.6 1 1 0 1 1 1 0 Redoxin DUF2955 PF11168.8 AET40213.1 - 0.3 10.9 16.4 1 9.2 3.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2955) EXS PF03124.14 AET40214.1 - 6.1e-68 229.6 30.7 7e-68 229.4 30.7 1.0 1 0 0 1 1 1 1 EXS family Ribosomal_L2_C PF03947.18 AET40215.1 - 1.1e-52 177.5 1.5 3.2e-52 176.0 1.5 1.8 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 AET40215.1 - 1e-28 99.1 0.4 2.6e-28 97.8 0.2 1.8 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain ATP-synt_D PF01813.17 AET40216.1 - 3.1e-68 229.5 3.0 4.3e-68 229.0 3.0 1.2 1 0 0 1 1 1 1 ATP synthase subunit D SYCE1 PF15233.6 AET40216.1 - 0.072 13.1 4.2 0.12 12.5 0.8 2.3 2 0 0 2 2 2 0 Synaptonemal complex central element protein 1 AFG1_ATPase PF03969.16 AET40217.1 - 6.9e-79 265.4 0.0 1.5e-74 251.1 0.0 3.0 2 1 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 AET40217.1 - 1.2e-05 25.8 0.1 0.00031 21.2 0.1 2.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AET40217.1 - 0.0019 18.5 0.0 0.004 17.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 AET40217.1 - 0.0052 17.2 0.0 0.013 16.0 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AET40217.1 - 0.006 16.6 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 AET40217.1 - 0.023 14.6 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 AET40217.1 - 0.056 13.8 0.0 0.23 11.9 0.0 2.1 2 1 1 3 3 3 0 RNA helicase TsaE PF02367.17 AET40217.1 - 0.087 12.8 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mak10 PF04112.13 AET40218.1 - 4.1e-44 150.0 0.4 8.8e-44 149.0 0.4 1.6 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Ribosomal_L11_N PF03946.14 AET40219.1 - 2e-21 75.6 1.1 4.5e-21 74.4 0.4 1.9 2 0 0 2 2 2 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 AET40219.1 - 1.6e-15 57.3 1.3 2.1e-15 57.0 0.3 1.7 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain ACBP PF00887.19 AET40220.1 - 1.8e-20 72.9 0.1 3.9e-20 71.9 0.1 1.6 1 0 0 1 1 1 1 Acyl CoA binding protein MAP65_ASE1 PF03999.12 AET40221.1 - 1.6e-99 334.2 34.1 1.6e-99 334.2 34.1 1.9 2 1 0 2 2 2 1 Microtubule associated protein (MAP65/ASE1 family) FeS_assembly_P PF01883.19 AET40221.1 - 0.033 14.4 0.2 0.76 10.0 0.0 2.9 3 0 0 3 3 3 0 Iron-sulfur cluster assembly protein Spore_III_AB PF09548.10 AET40221.1 - 0.16 12.1 12.5 0.55 10.3 0.5 3.5 2 1 1 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) V-SNARE PF05008.15 AET40221.1 - 3.4 8.1 8.2 0.48 10.8 0.8 3.4 3 0 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus DUF2203 PF09969.9 AET40221.1 - 4.6 8.0 7.3 4.1 8.2 0.1 3.9 3 1 2 5 5 5 0 Uncharacterized conserved protein (DUF2203) SGS PF05002.15 AET40222.1 - 8.5e-29 99.5 2.9 8.5e-29 99.5 2.9 2.6 3 0 0 3 3 3 1 SGS domain CS PF04969.16 AET40222.1 - 2e-09 38.3 0.2 5.4e-09 36.9 0.2 1.8 1 0 0 1 1 1 1 CS domain TPR_2 PF07719.17 AET40222.1 - 0.00076 19.4 2.7 0.13 12.5 0.4 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 AET40222.1 - 0.0021 17.8 3.1 0.11 12.4 0.5 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 AET40222.1 - 0.0025 18.5 0.4 0.017 15.9 0.1 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 AET40222.1 - 0.15 12.8 1.0 2.4 9.0 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 AET40222.1 - 0.16 12.4 2.1 0.29 11.6 0.5 2.3 1 1 1 2 2 2 0 Alkyl sulfatase dimerisation TPR_19 PF14559.6 AET40222.1 - 0.21 12.1 2.4 0.6 10.7 0.3 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat PIN_6 PF17146.4 AET40223.1 - 1.1e-31 109.2 0.0 3e-31 107.7 0.0 1.8 1 0 0 1 1 1 1 PIN domain of ribonuclease NOB1_Zn_bind PF08772.11 AET40223.1 - 9.9e-26 89.7 0.6 2.4e-25 88.5 0.6 1.7 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like Ocular_alb PF02101.15 AET40223.1 - 1.2 8.0 3.0 1.9 7.3 3.0 1.3 1 0 0 1 1 1 0 Ocular albinism type 1 protein Ima1_N PF09779.9 AET40223.1 - 4.2 8.2 8.2 0.62 10.9 1.8 2.4 2 0 0 2 2 2 0 Ima1 N-terminal domain Flavoprotein PF02441.19 AET40224.1 - 4.4e-49 166.3 0.6 8.4e-49 165.3 0.6 1.5 1 0 0 1 1 1 1 Flavoprotein BSP_II PF05432.11 AET40224.1 - 0.0027 17.5 27.3 0.0027 17.5 27.3 2.0 3 0 0 3 3 3 1 Bone sialoprotein II (BSP-II) Nop14 PF04147.12 AET40224.1 - 0.0028 15.9 34.7 0.0041 15.4 34.7 1.1 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 AET40224.1 - 0.057 12.8 39.5 0.087 12.2 39.5 1.2 1 0 0 1 1 1 0 SDA1 RR_TM4-6 PF06459.12 AET40224.1 - 0.61 9.9 9.0 1.2 8.8 9.0 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tim54 PF11711.8 AET40224.1 - 0.65 8.7 6.3 1.3 7.8 6.3 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SAPS PF04499.15 AET40224.1 - 1.9 7.2 13.8 1.5 7.5 12.4 1.5 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Hid1 PF12722.7 AET40224.1 - 3.1 5.8 7.2 5.7 4.9 7.2 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BUD22 PF09073.10 AET40224.1 - 4.2 6.6 38.8 9.6 5.4 38.8 1.5 1 0 0 1 1 1 0 BUD22 DUF4746 PF15928.5 AET40224.1 - 5.2 6.4 13.3 9.5 5.6 13.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CIAPIN1 PF05093.13 AET40225.1 - 3.1e-39 133.5 2.7 3.1e-39 133.5 2.7 2.1 2 0 0 2 2 2 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 AET40225.1 - 2.2e-30 105.6 0.1 4.6e-30 104.5 0.1 1.5 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus FAM198 PF15051.6 AET40225.1 - 0.017 14.0 0.1 0.027 13.4 0.1 1.2 1 0 0 1 1 1 0 FAM198 protein zf-CSL PF05207.13 AET40225.1 - 0.87 9.4 4.3 4.2 7.2 4.3 2.2 1 1 0 1 1 1 0 CSL zinc finger zf-AN1 PF01428.16 AET40226.1 - 3.2e-08 33.6 15.9 3.2e-08 33.6 15.9 2.7 2 1 0 2 2 2 1 AN1-like Zinc finger DUF2722 PF10846.8 AET40226.1 - 0.0083 15.1 8.6 0.011 14.8 8.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF3506 PF12014.8 AET40226.1 - 0.024 14.7 0.7 0.034 14.2 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3506) TFIIA PF03153.13 AET40226.1 - 0.23 11.4 13.2 0.26 11.2 13.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit UPF0560 PF10577.9 AET40226.1 - 0.24 9.8 9.3 0.32 9.5 9.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF853 PF05872.12 AET40226.1 - 0.35 9.4 3.4 0.44 9.1 3.4 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Presenilin PF01080.17 AET40226.1 - 0.58 8.9 5.5 0.58 8.9 5.5 1.1 1 0 0 1 1 1 0 Presenilin DUF4175 PF13779.6 AET40226.1 - 1.7 6.5 10.7 1.6 6.6 10.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Connexin PF00029.19 AET40226.1 - 1.9 8.2 7.2 2.3 7.9 7.2 1.2 1 0 0 1 1 1 0 Connexin BAT2_N PF07001.11 AET40226.1 - 2.1 8.8 13.3 1.6 9.1 12.1 1.4 1 1 0 1 1 1 0 BAT2 N-terminus TP_methylase PF00590.20 AET40227.1 - 9.1e-41 140.1 0.1 1.2e-40 139.7 0.1 1.2 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Sirohm_synth_M PF14824.6 AET40227.1 - 1.3e-07 30.9 0.0 2.4e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central NAD_binding_7 PF13241.6 AET40227.1 - 0.0005 20.5 0.0 0.0012 19.3 0.0 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 AET40227.1 - 0.014 15.0 0.0 0.8 9.4 0.0 2.4 2 0 0 2 2 2 0 Sirohaem biosynthesis protein C-terminal TRAPP PF04051.16 AET40228.1 - 6.5e-32 110.3 0.0 8.1e-32 110.0 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Dsl1_N PF11988.8 AET40228.1 - 0.0077 15.3 0.1 0.019 13.9 0.0 1.6 2 0 0 2 2 2 1 Retrograde transport protein Dsl1 N terminal DUF111 PF01969.17 AET40228.1 - 0.18 10.9 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF111 Acyltransferase PF01553.21 AET40229.1 - 1.7e-08 34.2 0.0 8e-08 32.0 0.0 2.1 1 1 0 1 1 1 1 Acyltransferase LIN52 PF10044.9 AET40229.1 - 0.11 13.2 0.2 1.6 9.5 0.1 2.3 2 0 0 2 2 2 0 Retinal tissue protein Nuclease_act PF08133.11 AET40229.1 - 2.9 8.2 4.7 0.95 9.7 1.2 2.1 2 0 0 2 2 2 0 Anticodon nuclease activator family Methyltransf_28 PF02636.17 AET40230.1 - 8.8e-06 25.5 0.1 1.3e-05 25.0 0.1 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase XRN_M PF17846.1 AET40231.1 - 1.2e-131 439.8 0.0 2.7e-129 432.0 0.0 2.4 1 1 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 AET40231.1 - 8.2e-98 326.7 0.0 5.9e-97 323.8 0.0 2.3 3 0 0 3 3 3 1 XRN 5'-3' exonuclease N-terminus Rubella_E2 PF05749.11 AET40231.1 - 0.12 11.8 3.6 0.2 11.1 3.6 1.2 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 Mucin PF01456.17 AET40231.1 - 0.4 10.7 10.6 0.74 9.8 10.6 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein STD1 PF17235.2 AET40232.1 - 1.5e-69 233.8 0.0 2.2e-69 233.2 0.0 1.2 1 0 0 1 1 1 1 STD1/MTH1 DEAD PF00270.29 AET40233.1 - 8.2e-36 123.4 0.4 1.5e-35 122.5 0.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET40233.1 - 1.3e-28 99.5 0.0 2.7e-28 98.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET40233.1 - 3.5e-07 30.4 0.0 6.3e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 AET40233.1 - 0.01 15.6 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain CMS1 PF14617.6 AET40233.1 - 0.052 12.9 0.1 0.68 9.2 0.1 2.2 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Pmp3 PF01679.17 AET40234.1 - 9.8e-17 60.9 10.7 1.1e-16 60.8 10.7 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Tom6 PF17112.5 AET40235.1 - 6.3e-27 92.8 3.2 7.9e-27 92.5 3.2 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom6, fungal CUE PF02845.16 AET40237.1 - 2.3e-05 24.0 0.0 4e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 CUE domain Spem1 PF15670.5 AET40237.1 - 2.8 7.4 5.8 1.2 8.6 3.1 1.8 1 1 1 2 2 2 0 Spermatid maturation protein 1 HAGH_C PF16123.5 AET40238.1 - 1.3e-17 64.1 0.3 2.6e-17 63.1 0.3 1.5 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 AET40238.1 - 6.3e-13 49.2 0.0 2.6e-12 47.2 0.0 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 AET40238.1 - 0.0097 15.4 0.2 0.018 14.6 0.2 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain BcrAD_BadFG PF01869.20 AET40238.1 - 0.16 11.5 0.1 0.26 10.8 0.1 1.3 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family E1-E2_ATPase PF00122.20 AET40239.1 - 4.8e-48 163.1 0.3 9.5e-48 162.1 0.3 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 AET40239.1 - 6.5e-28 98.4 0.0 1.2e-27 97.6 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 AET40239.1 - 1.6e-25 89.3 11.4 2.1e-13 50.5 0.8 2.5 2 0 0 2 2 2 2 Heavy-metal-associated domain Hydrolase_3 PF08282.12 AET40239.1 - 1.3e-07 31.6 0.1 0.0016 18.2 0.1 2.7 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase GP41 PF00517.17 AET40239.1 - 0.045 13.7 0.5 0.099 12.5 0.1 1.7 2 0 0 2 2 2 0 Retroviral envelope protein Fer2_BFD PF04324.15 AET40239.1 - 0.16 12.4 0.7 19 5.7 0.0 3.0 2 0 0 2 2 2 0 BFD-like [2Fe-2S] binding domain DUF1677 PF07911.13 AET40239.1 - 0.22 11.9 2.8 7.4 7.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1677) Adhesin_Dr PF04619.12 AET40239.1 - 0.39 10.6 3.0 0.5 10.3 0.3 2.3 2 0 0 2 2 2 0 Dr-family adhesin CK_II_beta PF01214.18 AET40240.1 - 7.7e-71 237.7 0.0 9.5e-71 237.4 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit RecG_N PF17190.4 AET40240.1 - 0.015 16.0 0.6 0.033 14.9 0.6 1.5 1 0 0 1 1 1 0 RecG N-terminal helical domain Hira PF07569.11 AET40241.1 - 6e-85 284.5 0.0 3e-84 282.2 0.0 2.1 2 0 0 2 2 2 1 TUP1-like enhancer of split WD40 PF00400.32 AET40241.1 - 0.014 16.3 0.4 4.1 8.4 0.0 3.4 3 0 0 3 3 3 0 WD domain, G-beta repeat tRNA-synt_1b PF00579.25 AET40242.1 - 4.2e-75 252.8 0.1 5e-75 252.5 0.1 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) FAD_binding_6 PF00970.24 AET40243.1 - 1.8e-06 28.2 0.0 1.4e-05 25.4 0.0 2.3 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain WD40 PF00400.32 AET40244.1 - 8.2e-37 124.6 25.6 5.5e-07 30.2 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET40244.1 - 6.2e-14 52.1 6.5 7.9e-06 26.1 0.1 4.7 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain CRT10 PF08728.10 AET40244.1 - 0.026 12.7 1.1 1.3 7.1 0.0 2.9 3 0 0 3 3 3 0 CRT10 Coatomer_WDAD PF04053.14 AET40244.1 - 0.049 12.7 3.7 0.12 11.4 0.8 2.5 2 1 1 3 3 3 0 Coatomer WD associated region Mcl1_mid PF12341.8 AET40244.1 - 0.051 12.9 0.5 0.13 11.6 0.1 1.9 2 1 1 3 3 3 0 Minichromosome loss protein, Mcl1, middle region IKI3 PF04762.12 AET40244.1 - 0.056 11.4 2.8 0.14 10.1 0.3 2.2 1 1 0 2 2 2 0 IKI3 family Syntaxin_2 PF14523.6 AET40245.1 - 9.8e-18 64.4 6.3 9.8e-18 64.4 6.3 2.4 2 0 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 AET40245.1 - 8.7e-15 54.5 0.7 2.1e-14 53.2 0.7 1.7 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 AET40245.1 - 5.8e-08 32.7 10.5 8.9e-08 32.0 10.5 1.3 1 0 0 1 1 1 1 Syntaxin Spc110_C PF18520.1 AET40247.1 - 0.027 14.0 0.0 0.078 12.6 0.0 1.7 1 0 0 1 1 1 0 Spindle pole body component 110 C-terminal domain DUF1236 PF06823.12 AET40247.1 - 0.042 13.7 0.0 6.3 6.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1236) Pkinase PF00069.25 AET40248.1 - 2.1e-66 224.0 0.0 3.6e-66 223.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40248.1 - 3.8e-52 177.1 0.0 6.1e-52 176.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AET40248.1 - 9.8e-07 27.9 0.0 5.5e-05 22.1 0.0 2.4 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 AET40248.1 - 5.5e-05 22.6 0.1 0.0061 15.9 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 AET40248.1 - 0.01 14.8 0.3 1.2 8.0 0.1 2.4 2 0 0 2 2 2 0 Haspin like kinase domain APH PF01636.23 AET40248.1 - 0.012 15.5 0.1 3.5 7.5 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family SBE2 PF17076.5 AET40249.1 - 5.1e-191 636.9 39.0 2.8e-190 634.5 39.0 2.0 1 1 0 1 1 1 1 SBE2, cell-wall formation PQ-loop PF04193.14 AET40250.1 - 9.2e-30 102.2 14.8 1.7e-16 59.7 1.5 2.6 3 0 0 3 3 3 2 PQ loop repeat CAP_N PF01213.19 AET40250.1 - 0.0059 16.1 0.2 0.008 15.7 0.2 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 AET40250.1 - 0.3 11.2 3.6 0.4 10.7 3.6 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator PRIMA1 PF16101.5 AET40250.1 - 0.49 10.4 4.2 1.1 9.3 4.2 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Aldo_ket_red PF00248.21 AET40251.1 - 2.9e-46 158.0 0.0 3.9e-46 157.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family PX PF00787.24 AET40252.1 - 1.4e-13 50.8 0.1 1.9e-13 50.3 0.1 1.2 1 0 0 1 1 1 1 PX domain Pyr_redox_2 PF07992.14 AET40253.1 - 5.8e-49 166.9 0.1 6.7e-49 166.7 0.1 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AET40253.1 - 4.2e-17 62.5 0.4 1.6e-14 54.2 0.1 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AET40253.1 - 3.8e-15 55.9 0.0 1e-13 51.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 AET40253.1 - 1.9e-05 24.0 0.5 0.93 8.5 0.2 4.0 3 1 0 4 4 4 2 Glucose inhibited division protein A NAD_binding_7 PF13241.6 AET40253.1 - 0.00022 21.6 0.0 0.14 12.6 0.0 2.4 2 0 0 2 2 2 2 Putative NAD(P)-binding FAD_binding_2 PF00890.24 AET40253.1 - 0.00056 19.1 1.9 0.73 8.8 0.1 2.9 3 1 0 3 3 3 2 FAD binding domain NAD_binding_8 PF13450.6 AET40253.1 - 0.00068 19.8 0.1 0.035 14.3 0.1 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 AET40253.1 - 0.002 17.3 0.0 1.3 8.1 0.0 2.9 2 1 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 AET40253.1 - 0.0026 17.0 0.0 0.011 15.0 0.0 1.9 2 0 0 2 2 2 1 Thi4 family Shikimate_DH PF01488.20 AET40253.1 - 0.0084 16.2 0.1 2.8 8.0 0.0 2.7 2 1 1 3 3 3 1 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.19 AET40253.1 - 0.015 14.6 0.0 4.3 6.5 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain DAO PF01266.24 AET40253.1 - 0.047 13.3 0.0 3.4 7.2 0.0 2.4 2 0 0 2 2 2 0 FAD dependent oxidoreductase Glycos_transf_3 PF00591.21 AET40254.1 - 2e-74 250.4 0.0 2.7e-74 250.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 AET40254.1 - 0.0041 16.9 0.1 0.0076 16.1 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain Methyltransf_16 PF10294.9 AET40255.1 - 1.1e-21 77.4 0.0 2.2e-21 76.4 0.0 1.5 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 AET40255.1 - 3.4e-08 33.5 0.0 5.3e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AET40255.1 - 3.4e-07 30.2 0.0 7.1e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AET40255.1 - 0.0015 18.1 0.0 0.0025 17.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 AET40255.1 - 0.0022 17.7 0.0 0.0037 16.9 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 AET40255.1 - 0.0042 17.8 0.0 0.008 16.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AET40255.1 - 0.01 16.5 0.0 0.038 14.7 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Met_10 PF02475.16 AET40255.1 - 0.21 11.3 0.0 0.35 10.6 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Spc110_C PF18520.1 AET40256.1 - 3e-29 100.4 2.0 5.2e-28 96.4 0.8 3.2 2 0 0 2 2 2 1 Spindle pole body component 110 C-terminal domain T7SS_ESX_EspC PF10824.8 AET40256.1 - 0.00016 22.1 1.4 0.027 14.9 0.2 3.7 3 0 0 3 3 3 1 Excreted virulence factor EspC, type VII ESX diderm DHR10 PF18595.1 AET40256.1 - 0.00026 21.0 14.8 0.00026 21.0 14.8 9.6 2 2 6 9 9 8 1 Designed helical repeat protein 10 domain Cnn_1N PF07989.11 AET40256.1 - 0.0017 18.5 6.4 0.0017 18.5 6.4 9.7 5 1 2 9 9 9 2 Centrosomin N-terminal motif 1 M PF02370.16 AET40256.1 - 0.045 14.3 0.5 0.045 14.3 0.5 9.4 9 1 1 10 10 8 0 M protein repeat Fez1 PF06818.15 AET40256.1 - 0.053 14.0 99.3 0.15 12.5 17.9 6.4 1 1 5 6 6 6 0 Fez1 Mac PF12464.8 AET40256.1 - 0.73 10.1 8.3 2 8.7 0.7 3.8 3 0 0 3 3 3 0 Maltose acetyltransferase Syntaxin-6_N PF09177.11 AET40256.1 - 2.4 8.8 64.7 0.97 10.0 2.7 7.3 1 1 4 7 7 7 0 Syntaxin 6, N-terminal PACT_coil_coil PF10495.9 AET40256.1 - 2.4 8.8 0.0 2.4 8.8 0.0 4.3 3 1 0 3 3 2 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein NPV_P10 PF05531.12 AET40256.1 - 2.7 8.5 30.5 6.1 7.4 8.0 7.9 3 2 3 6 6 6 0 Nucleopolyhedrovirus P10 protein Spc7 PF08317.11 AET40256.1 - 7.9 5.3 107.7 0.18 10.7 14.5 6.4 2 1 4 7 7 7 0 Spc7 kinetochore protein BORCS6 PF10157.9 AET40257.1 - 0.048 13.9 0.2 0.31 11.3 0.1 2.0 1 1 1 2 2 2 0 BLOC-1-related complex sub-unit 6 VHS PF00790.19 AET40258.1 - 6.1e-47 159.0 0.1 4.7e-46 156.2 0.0 2.2 2 0 0 2 2 2 1 VHS domain Alpha_adaptinC2 PF02883.20 AET40258.1 - 2.2e-20 73.0 0.0 4.6e-20 72.0 0.0 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain GAT PF03127.14 AET40258.1 - 6.7e-18 64.8 0.5 4.4e-17 62.2 0.5 2.5 2 0 0 2 2 2 1 GAT domain GGA_N-GAT PF18308.1 AET40258.1 - 1.2e-06 28.0 0.2 5e-06 26.0 0.2 2.1 1 0 0 1 1 1 1 GGA N-GAT domain DUF5344 PF17279.2 AET40258.1 - 0.044 14.4 0.6 0.14 12.8 0.6 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5344) DUF3829 PF12889.7 AET40258.1 - 0.045 13.2 2.6 0.08 12.4 2.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) Muted PF14942.6 AET40258.1 - 0.51 10.7 6.0 0.99 9.7 6.0 1.5 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein HSA PF07529.13 AET40259.1 - 4.1e-13 49.5 0.6 4.1e-13 49.5 0.6 3.1 3 0 0 3 3 3 1 HSA Myb_DNA-bind_6 PF13921.6 AET40259.1 - 1.6e-08 34.7 0.6 1.6e-08 34.7 0.6 2.8 2 1 1 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 AET40259.1 - 0.0005 20.2 0.1 0.0036 17.5 0.0 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain BTB_3 PF16017.5 AET40259.1 - 0.16 12.1 0.0 0.44 10.7 0.0 1.7 1 0 0 1 1 1 0 BTB/POZ domain BCIP PF13862.6 AET40260.1 - 3.6e-49 167.4 0.8 4.8e-49 167.0 0.8 1.2 1 0 0 1 1 1 1 p21-C-terminal region-binding protein PBP1_TM PF14812.6 AET40260.1 - 2.1 8.8 12.2 1.1 9.7 4.5 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal EMP24_GP25L PF01105.24 AET40261.1 - 3.8e-38 131.3 0.6 4.3e-38 131.1 0.6 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD ThiF PF00899.21 AET40262.1 - 1.4e-59 201.4 0.0 2.3e-59 200.7 0.0 1.2 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 AET40262.1 - 1.8e-11 44.5 0.0 4.1e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Shikimate_DH PF01488.20 AET40262.1 - 0.00019 21.5 0.0 0.0014 18.7 0.0 2.3 2 1 1 3 3 3 1 Shikimate / quinate 5-dehydrogenase Prp19 PF08606.11 AET40262.1 - 0.075 13.0 2.0 0.26 11.3 2.0 1.9 1 0 0 1 1 1 0 Prp19/Pso4-like NAD_binding_7 PF13241.6 AET40262.1 - 0.17 12.3 0.0 0.37 11.2 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding APG6_N PF17675.1 AET40262.1 - 0.19 12.2 8.6 0.55 10.8 6.0 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region CCDC144C PF14915.6 AET40262.1 - 0.65 9.0 7.5 0.59 9.2 3.8 2.1 2 0 0 2 2 2 0 CCDC144C protein coiled-coil region WD40 PF00400.32 AET40263.1 - 0.44 11.5 5.0 5.1 8.1 0.7 4.1 4 1 0 4 4 4 0 WD domain, G-beta repeat Cys_Met_Meta_PP PF01053.20 AET40264.1 - 3.1e-63 213.6 0.0 9e-63 212.1 0.0 1.7 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 AET40264.1 - 0.0015 17.6 0.0 0.0029 16.6 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 AET40264.1 - 0.011 15.0 0.0 0.016 14.4 0.0 1.4 1 1 0 1 1 1 0 Aminotransferase class I and II Rad60-SLD PF11976.8 AET40265.1 - 3.2e-21 74.9 2.8 1.4e-20 72.8 0.2 2.7 2 1 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 AET40265.1 - 0.014 15.1 0.1 0.045 13.5 0.1 1.8 1 0 0 1 1 1 0 Ubiquitin family RNA_pol_Rpb1_1 PF04997.12 AET40266.1 - 2.9e-82 276.5 0.0 8.3e-82 275.0 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 AET40266.1 - 2e-81 273.4 0.2 2.8e-81 272.9 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 AET40266.1 - 2.2e-76 255.7 0.1 4.7e-76 254.6 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 AET40266.1 - 7.9e-39 133.1 0.0 2.1e-38 131.7 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 AET40266.1 - 1.8e-30 105.1 0.0 4.3e-30 103.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 DSS1_SEM1 PF05160.13 AET40267.1 - 7.8e-20 70.7 14.0 8.8e-20 70.5 14.0 1.0 1 0 0 1 1 1 1 DSS1/SEM1 family AAA PF00004.29 AET40268.1 - 6.3e-41 139.9 0.0 1.2e-40 139.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 AET40268.1 - 1.9e-18 66.2 0.1 4.4e-18 65.0 0.1 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 AET40268.1 - 1.4e-07 31.2 0.0 3.2e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 AET40268.1 - 1.6e-05 25.4 0.1 0.016 15.6 0.0 2.5 1 1 1 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 AET40268.1 - 2.5e-05 24.5 0.0 0.00022 21.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 AET40268.1 - 6.1e-05 23.0 0.1 0.00036 20.6 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 AET40268.1 - 0.00066 19.5 0.0 0.0017 18.1 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 AET40268.1 - 0.0008 19.7 0.2 0.077 13.3 0.0 2.6 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 AET40268.1 - 0.0056 16.8 0.0 0.024 14.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 AET40268.1 - 0.0066 15.9 0.2 0.041 13.3 0.1 2.1 2 0 0 2 2 2 1 PhoH-like protein DUF815 PF05673.13 AET40268.1 - 0.011 14.9 0.0 0.022 13.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 AET40268.1 - 0.014 14.8 0.2 0.038 13.4 0.1 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TolA_bind_tri PF16331.5 AET40268.1 - 0.019 15.0 2.1 0.072 13.2 0.7 2.5 2 0 0 2 2 2 0 TolA binding protein trimerisation IstB_IS21 PF01695.17 AET40268.1 - 0.025 14.3 0.2 0.058 13.1 0.0 1.7 2 0 0 2 2 1 0 IstB-like ATP binding protein ExbD PF02472.16 AET40268.1 - 0.047 13.8 0.7 0.15 12.2 0.0 2.1 2 1 0 2 2 2 0 Biopolymer transport protein ExbD/TolR AAA_11 PF13086.6 AET40268.1 - 0.048 13.4 0.3 0.18 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 AET40268.1 - 0.062 13.6 0.5 0.15 12.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 AET40268.1 - 0.065 12.7 0.0 0.14 11.7 0.0 1.5 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 AET40268.1 - 0.093 12.4 0.1 0.31 10.7 0.1 2.1 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 AET40268.1 - 0.21 10.9 1.1 0.46 9.8 0.0 2.0 3 0 0 3 3 3 0 KaiC ThylakoidFormat PF11264.8 AET40268.1 - 0.28 10.8 3.2 0.57 9.8 3.2 1.5 1 0 0 1 1 1 0 Thylakoid formation protein WD40 PF00400.32 AET40269.1 - 5.3e-25 87.2 11.6 4.1e-07 30.6 0.1 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET40269.1 - 1.7e-09 37.9 0.0 0.21 11.9 0.0 4.3 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AET40269.1 - 1.7e-05 24.8 1.9 0.012 15.5 0.3 3.3 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A RAB3GAP2_N PF14655.6 AET40269.1 - 0.086 12.1 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF846 PF05832.12 AET40270.1 - 3.7e-45 153.4 5.7 4.4e-45 153.1 5.7 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Serglycin PF04360.12 AET40270.1 - 0.037 14.0 0.3 0.037 14.0 0.3 1.7 2 0 0 2 2 2 0 Serglycin TraL PF07178.11 AET40270.1 - 7.7 7.1 8.0 14 6.2 2.3 2.1 2 0 0 2 2 2 0 TraL protein Methyltransf_8 PF05148.15 AET40271.1 - 1.6e-66 224.3 2.5 1.3e-64 218.1 0.5 2.4 1 1 1 2 2 2 2 Hypothetical methyltransferase Methyltransf_11 PF08241.12 AET40271.1 - 5.5e-07 30.1 0.0 1.7e-06 28.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AET40271.1 - 5.5e-06 27.0 0.0 2.4e-05 24.9 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 AET40271.1 - 0.00023 20.7 0.8 0.22 11.0 0.2 2.5 2 0 0 2 2 2 2 Putative methyltransferase Methyltransf_31 PF13847.6 AET40271.1 - 0.0008 19.2 0.1 0.0077 16.0 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AET40271.1 - 0.024 14.2 0.0 0.48 9.9 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_32 PF13679.6 AET40271.1 - 0.82 9.6 0.0 0.82 9.6 0.0 2.5 3 0 0 3 3 3 0 Methyltransferase domain Stn1 PF10451.9 AET40272.1 - 6.4e-46 156.4 0.5 1.2e-45 155.5 0.5 1.4 1 0 0 1 1 1 1 Telomere regulation protein Stn1 Stn1_C PF12659.7 AET40272.1 - 2.2e-30 105.1 3.3 2.2e-30 105.1 3.3 2.7 3 0 0 3 3 3 1 Telomere capping C-terminal wHTH tRNA_anti-codon PF01336.25 AET40272.1 - 0.011 15.7 0.0 0.023 14.7 0.0 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain DDE_1 PF03184.19 AET40273.1 - 1.5e-58 197.3 0.4 2.7e-58 196.5 0.4 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 AET40273.1 - 1.1e-12 47.7 0.1 3.3e-12 46.2 0.1 1.9 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_ABP1_N PF18107.1 AET40273.1 - 0.00069 19.3 0.0 0.002 17.8 0.0 1.8 1 0 0 1 1 1 1 Fission yeast centromere protein N-terminal domain KCT2 PF17818.1 AET40273.1 - 0.14 12.3 2.6 0.19 11.9 1.1 1.9 2 0 0 2 2 2 0 Keratinocyte-associated gene product Clathrin PF00637.20 AET40274.1 - 3.8e-29 101.4 10.5 6.6e-29 100.6 0.6 2.8 2 1 0 2 2 2 2 Region in Clathrin and VPS Vps39_1 PF10366.9 AET40274.1 - 0.0012 19.2 2.5 0.0027 17.9 0.0 2.7 2 1 1 3 3 3 1 Vacuolar sorting protein 39 domain 1 WD40 PF00400.32 AET40274.1 - 0.0039 18.0 0.0 0.017 16.0 0.0 2.2 1 0 0 1 1 1 1 WD domain, G-beta repeat Tfb5 PF06331.12 AET40275.1 - 3e-26 91.2 0.0 3.3e-26 91.0 0.0 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 Sec34 PF04136.15 AET40276.1 - 2.2e-41 141.2 9.1 2.2e-41 141.2 9.1 3.6 5 0 0 5 5 5 1 Sec34-like family DrrA_P4M PF14860.6 AET40276.1 - 7.7 6.4 7.6 2 8.3 0.2 3.3 4 0 0 4 4 4 0 DrrA phosphatidylinositol 4-phosphate binding domain Fib_alpha PF08702.10 AET40276.1 - 7.9 6.7 16.8 2.6 8.2 1.2 4.2 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family Pet100 PF09803.9 AET40277.1 - 1.8e-09 38.0 1.1 2e-09 37.8 0.1 1.6 2 0 0 2 2 2 1 Pet100 HU-CCDC81_bac_2 PF18175.1 AET40277.1 - 0.078 12.9 0.5 9.4 6.2 0.2 2.2 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 UPF0160 PF03690.13 AET40278.1 - 9.2e-126 419.8 0.0 1e-125 419.6 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) RhoGAP PF00620.27 AET40279.1 - 4.7e-40 136.9 0.2 2.2e-39 134.7 0.2 2.3 1 0 0 1 1 1 1 RhoGAP domain RasGEF_N PF00618.20 AET40279.1 - 6.4e-19 68.1 4.1 2.4e-18 66.3 1.2 3.5 2 0 0 2 2 2 1 RasGEF N-terminal motif RasGEF PF00617.19 AET40279.1 - 4.1e-15 56.4 8.2 1.1e-13 51.7 0.4 4.1 3 0 0 3 3 3 2 RasGEF domain PH PF00169.29 AET40279.1 - 0.00011 22.6 0.1 0.00056 20.4 0.0 2.3 2 0 0 2 2 2 1 PH domain DUF2959 PF11172.8 AET40279.1 - 0.7 10.0 5.7 0.19 11.8 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2959) 60KD_IMP PF02096.20 AET40280.1 - 2.8e-19 69.6 1.1 2.8e-19 69.6 1.1 1.7 2 0 0 2 2 2 1 60Kd inner membrane protein PET122 PF05476.11 AET40281.1 - 1e-71 241.3 8.5 1.3e-71 240.9 8.5 1.0 1 0 0 1 1 1 1 PET122 Aminotran_1_2 PF00155.21 AET40282.1 - 1.4e-19 70.5 0.0 1.9e-19 70.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 AET40282.1 - 0.01 14.6 0.0 0.018 13.8 0.0 1.3 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase SWIM PF04434.17 AET40283.1 - 0.036 13.7 1.2 0.79 9.5 0.1 2.4 2 0 0 2 2 2 0 SWIM zinc finger UCH PF00443.29 AET40284.1 - 9.1e-49 166.3 0.9 2.7e-48 164.7 0.9 1.8 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AET40284.1 - 7.1e-07 29.1 2.7 2e-05 24.4 0.9 2.6 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase MgtE_N PF03448.17 AET40284.1 - 0.031 14.9 0.1 0.065 13.8 0.1 1.5 1 0 0 1 1 1 0 MgtE intracellular N domain DUF5039 PF16442.5 AET40285.1 - 4.4e-05 23.1 0.6 40 3.7 0.0 4.9 5 0 0 5 5 5 4 Domain of unknown function (DUF5039) E1-E2_ATPase PF00122.20 AET40285.1 - 0.84 9.1 24.7 11 5.5 0.4 5.2 5 0 0 5 5 5 0 E1-E2 ATPase YobH PF13996.6 AET40285.1 - 3.3 7.8 13.6 85 3.3 0.2 5.0 5 0 0 5 5 5 0 YobH-like protein ATPase PF06745.13 AET40286.1 - 6.6e-09 35.5 0.0 1.3e-08 34.5 0.0 1.4 1 1 0 1 1 1 1 KaiC Rad51 PF08423.11 AET40286.1 - 1.7e-07 30.8 0.3 1.5e-06 27.7 0.0 2.1 2 0 0 2 2 2 1 Rad51 RecA PF00154.21 AET40286.1 - 0.00041 19.9 0.1 0.0013 18.3 0.1 1.8 1 1 0 1 1 1 1 recA bacterial DNA recombination protein ATPase_2 PF01637.18 AET40286.1 - 0.0017 18.3 0.1 0.0033 17.4 0.1 1.5 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea DnaB_C PF03796.15 AET40286.1 - 0.0019 17.6 0.0 0.0051 16.2 0.0 1.8 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_24 PF13479.6 AET40286.1 - 0.0025 17.5 0.0 0.0042 16.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 AET40286.1 - 0.0063 16.9 0.0 0.015 15.8 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AET40286.1 - 0.0096 16.2 0.0 0.022 15.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 AET40286.1 - 0.015 15.1 0.0 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain nec1 PF10379.9 AET40286.1 - 0.046 13.2 0.0 0.086 12.3 0.0 1.4 1 0 0 1 1 1 0 Virulence protein nec1 AAA_18 PF13238.6 AET40286.1 - 0.12 12.9 0.0 0.21 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Metallophos PF00149.28 AET40287.1 - 1.6e-37 130.0 0.2 2e-37 129.7 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AET40287.1 - 0.00044 20.5 0.0 0.00062 20.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Glyco_hydro_65N PF03636.15 AET40287.1 - 0.13 11.9 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain BBP1_C PF15272.6 AET40288.1 - 0.001 18.9 4.2 0.001 18.9 4.2 2.6 3 0 0 3 3 3 1 Spindle pole body component BBP1, C-terminal BRE1 PF08647.11 AET40288.1 - 0.02 14.9 4.0 0.02 14.9 4.0 2.7 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase APC_N_CC PF16689.5 AET40288.1 - 0.024 14.7 6.8 0.024 14.7 6.8 3.2 2 1 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain Herpes_UL6 PF01763.16 AET40288.1 - 0.18 10.3 8.0 0.12 10.8 3.9 2.0 1 1 1 2 2 2 0 Herpesvirus UL6 like Cnn_1N PF07989.11 AET40288.1 - 0.71 10.1 14.6 0.037 14.2 6.5 2.7 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 DUF4140 PF13600.6 AET40288.1 - 0.81 10.2 8.3 0.3 11.6 2.0 2.6 1 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) TBP PF00352.21 AET40289.1 - 6.1e-68 224.8 0.1 1.1e-32 111.8 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 AET40289.1 - 2.1e-05 24.6 0.1 0.21 11.8 0.0 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 AET40289.1 - 0.037 13.8 0.2 0.26 11.1 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) Cohesin_load PF10345.9 AET40290.1 - 1.4e-79 268.2 23.2 1.8e-79 267.8 23.2 1.1 1 0 0 1 1 1 1 Cohesin loading factor CAAX_1 PF15895.5 AET40290.1 - 0.18 11.7 0.0 0.45 10.4 0.0 1.6 2 0 0 2 2 2 0 CAAX box cerebral protein 1 Hormone_3 PF00159.18 AET40290.1 - 1.5 8.9 3.2 13 5.9 0.8 2.7 2 0 0 2 2 2 0 Pancreatic hormone peptide Glyco_transf_20 PF00982.21 AET40291.1 - 6.3e-149 496.7 0.2 8.3e-149 496.3 0.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 AET40291.1 - 2.6e-77 259.1 0.0 4.1e-77 258.4 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase PAP2_3 PF14378.6 AET40293.1 - 1.9e-11 44.0 13.6 1.5e-10 41.1 4.8 3.0 3 1 1 4 4 4 2 PAP2 superfamily PAP2 PF01569.21 AET40293.1 - 2.2e-06 27.5 17.1 2.6e-06 27.2 1.3 3.3 4 1 0 4 4 4 2 PAP2 superfamily TMEM190 PF15431.6 AET40293.1 - 0.56 10.4 2.3 8.9 6.5 0.8 2.6 2 0 0 2 2 2 0 Transmembrane protein 190 LSM PF01423.22 AET40294.1 - 9.1e-20 70.1 0.4 1e-19 70.0 0.4 1.0 1 0 0 1 1 1 1 LSM domain BPL_C PF02237.17 AET40294.1 - 0.032 14.1 0.0 0.074 13.0 0.0 1.7 2 0 0 2 2 2 0 Biotin protein ligase C terminal domain FTR1 PF03239.14 AET40295.1 - 1.7e-93 313.2 12.6 2e-93 312.9 12.6 1.1 1 0 0 1 1 1 1 Iron permease FTR1 family DUF1218 PF06749.12 AET40295.1 - 2.7 8.6 7.6 10 6.7 0.1 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1218) Acetyltransf_1 PF00583.25 AET40296.1 - 5.1e-18 65.4 0.0 8.7e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AET40296.1 - 7.6e-09 35.6 0.0 1.3e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AET40296.1 - 9.3e-06 26.0 0.0 1.5e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 AET40296.1 - 1.3e-05 25.3 0.0 0.0063 16.6 0.0 2.1 1 1 1 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 AET40296.1 - 0.0075 16.4 0.0 0.012 15.7 0.0 1.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 AET40296.1 - 0.027 14.6 0.0 0.047 13.8 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase FR47 PF08445.10 AET40296.1 - 0.093 12.7 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein ABC_tran PF00005.27 AET40297.1 - 1.1e-21 77.8 0.0 6.5e-12 46.1 0.0 2.6 2 1 0 2 2 2 2 ABC transporter SbcCD_C PF13558.6 AET40297.1 - 4.3e-06 26.9 0.1 0.00029 21.0 0.0 2.3 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 AET40297.1 - 8.2e-06 25.8 0.1 0.15 11.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AET40297.1 - 0.0013 18.4 0.1 0.0042 16.8 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain SMC_N PF02463.19 AET40297.1 - 0.0048 16.4 0.4 2.5 7.5 0.0 3.0 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain Ploopntkinase1 PF18748.1 AET40297.1 - 0.0098 15.4 0.0 0.033 13.7 0.0 1.8 2 0 0 2 2 2 1 P-loop Nucleotide Kinase1 AAA_22 PF13401.6 AET40297.1 - 0.063 13.6 0.2 2.7 8.2 0.1 2.8 2 1 0 2 2 2 0 AAA domain Aminotran_1_2 PF00155.21 AET40298.1 - 8.8e-66 222.5 0.0 1.1e-65 222.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AET40298.1 - 0.001 18.1 0.0 0.0015 17.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cullin_Nedd8 PF10557.9 AET40298.1 - 0.04 14.0 0.1 11 6.1 0.0 3.0 3 0 0 3 3 3 0 Cullin protein neddylation domain OKR_DC_1 PF01276.20 AET40298.1 - 0.084 11.6 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Phosphodiest PF01663.22 AET40299.1 - 1.8e-14 54.1 2.6 3.2e-14 53.3 2.6 1.4 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 AET40299.1 - 0.0058 16.1 0.1 0.011 15.2 0.1 1.4 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 AET40299.1 - 0.0068 15.8 1.1 0.0068 15.8 1.1 1.6 2 0 0 2 2 2 1 Metalloenzyme superfamily CotH PF08757.11 AET40299.1 - 0.044 13.3 0.1 0.082 12.4 0.1 1.3 1 0 0 1 1 1 0 CotH kinase protein DUF2976 PF11190.8 AET40299.1 - 7.6 6.4 9.5 0.41 10.5 1.7 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF2976) ABC_tran PF00005.27 AET40300.1 - 4e-34 118.1 0.0 5.1e-16 59.4 0.0 2.4 2 0 0 2 2 2 2 ABC transporter RLI PF04068.15 AET40300.1 - 4.4e-15 55.2 5.8 9.8e-15 54.1 5.8 1.6 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.6 AET40300.1 - 4.8e-11 43.0 9.0 0.074 12.9 0.1 4.2 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AET40300.1 - 2e-08 33.9 2.6 0.015 14.7 0.2 3.8 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain Fer4 PF00037.27 AET40300.1 - 3.1e-08 33.1 2.9 3.1e-08 33.1 2.9 3.0 3 0 0 3 3 3 1 4Fe-4S binding domain AAA_16 PF13191.6 AET40300.1 - 6.2e-07 29.9 0.0 0.0027 18.1 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 AET40300.1 - 3.5e-06 27.0 0.0 0.055 13.4 0.0 2.7 3 0 0 3 3 2 2 RsgA GTPase Fer4_6 PF12837.7 AET40300.1 - 5.7e-06 26.2 12.3 4.1e-05 23.5 2.0 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain AAA PF00004.29 AET40300.1 - 6.4e-06 26.6 0.0 0.023 15.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 AET40300.1 - 9.2e-06 25.6 0.4 0.095 12.4 0.0 3.1 3 0 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 AET40300.1 - 5.2e-05 23.5 0.0 0.015 15.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 AET40300.1 - 0.00015 21.4 0.8 0.45 10.3 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Fer4_21 PF14697.6 AET40300.1 - 0.00037 20.6 12.6 0.00082 19.5 12.6 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Rad17 PF03215.15 AET40300.1 - 0.00047 20.1 0.3 0.81 9.6 0.1 2.8 2 1 0 3 3 3 1 Rad17 P-loop domain Fer4_7 PF12838.7 AET40300.1 - 0.00093 19.7 0.4 0.00093 19.7 0.4 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain AAA_30 PF13604.6 AET40300.1 - 0.0014 18.4 0.3 0.1 12.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 AET40300.1 - 0.0024 17.1 0.0 0.6 9.3 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain AAA_24 PF13479.6 AET40300.1 - 0.0025 17.5 0.1 0.88 9.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 AET40300.1 - 0.0028 17.9 0.0 1.6 8.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 AET40300.1 - 0.0041 17.3 0.0 0.95 9.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain Fer4_10 PF13237.6 AET40300.1 - 0.0041 17.2 1.6 0.0041 17.2 1.6 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 AET40300.1 - 0.0045 17.1 11.7 0.0091 16.1 11.7 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain RNA_helicase PF00910.22 AET40300.1 - 0.0046 17.3 0.0 2 8.9 0.0 3.0 3 0 0 3 3 2 1 RNA helicase Fer4_2 PF12797.7 AET40300.1 - 0.0048 16.9 1.0 0.0048 16.9 1.0 2.6 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_23 PF13476.6 AET40300.1 - 0.0067 16.9 7.0 0.052 14.1 0.0 3.1 2 1 0 3 3 3 1 AAA domain NACHT PF05729.12 AET40300.1 - 0.0087 16.0 1.4 0.74 9.7 0.0 2.5 2 0 0 2 2 2 1 NACHT domain Fer4_16 PF13484.6 AET40300.1 - 0.01 16.7 0.2 0.01 16.7 0.2 2.9 2 1 1 3 3 1 0 4Fe-4S double cluster binding domain SRP54 PF00448.22 AET40300.1 - 0.015 14.9 2.8 0.74 9.4 0.1 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_5 PF07728.14 AET40300.1 - 0.016 15.2 0.8 0.19 11.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 AET40300.1 - 0.019 15.5 0.0 10 6.7 0.0 2.9 3 0 0 3 3 2 0 AAA domain TsaE PF02367.17 AET40300.1 - 0.03 14.3 0.1 0.39 10.7 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MMR_HSR1 PF01926.23 AET40300.1 - 0.03 14.4 0.0 6 7.0 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase TniB PF05621.11 AET40300.1 - 0.038 13.4 0.1 1.3 8.4 0.0 2.7 3 0 0 3 3 3 0 Bacterial TniB protein Fer4_17 PF13534.6 AET40300.1 - 0.042 14.4 0.1 0.042 14.4 0.1 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain AAA_14 PF13173.6 AET40300.1 - 0.057 13.5 0.1 17 5.4 0.0 3.1 3 0 0 3 3 2 0 AAA domain SbcCD_C PF13558.6 AET40300.1 - 0.084 13.1 0.0 14 6.0 0.0 2.8 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_7 PF12775.7 AET40300.1 - 0.093 12.2 0.2 0.93 9.0 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region VirE PF05272.11 AET40300.1 - 0.11 12.3 0.0 4.8 6.9 0.0 2.5 2 0 0 2 2 2 0 Virulence-associated protein E DUF815 PF05673.13 AET40300.1 - 0.11 11.6 0.0 3.8 6.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Fer4_8 PF13183.6 AET40300.1 - 0.15 12.6 0.1 0.15 12.6 0.1 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain DLIC PF05783.11 AET40300.1 - 0.15 10.9 0.0 0.3 9.8 0.0 1.4 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_13 PF13166.6 AET40300.1 - 0.19 10.4 0.3 0.77 8.3 0.0 2.1 3 0 0 3 3 3 0 AAA domain Fer4_4 PF12800.7 AET40300.1 - 0.69 10.6 14.7 0.26 11.9 2.8 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain RRM_1 PF00076.22 AET40301.1 - 7.2e-84 275.6 4.4 5e-20 71.1 0.1 4.8 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 AET40301.1 - 4.2e-18 65.3 7.8 9e-18 64.2 1.8 3.4 3 0 0 3 3 3 1 Poly-adenylate binding protein, unique domain RRM_3 PF08777.11 AET40301.1 - 1.4e-07 31.5 7.0 0.35 11.0 0.1 5.1 5 1 0 5 5 5 3 RNA binding motif RRM_occluded PF16842.5 AET40301.1 - 2.7e-06 27.1 0.0 0.0012 18.7 0.0 3.5 4 0 0 4 4 4 1 Occluded RNA-recognition motif RRM_7 PF16367.5 AET40301.1 - 0.00051 20.1 0.9 7.1 6.8 0.0 5.0 4 3 0 4 4 4 1 RNA recognition motif DUF4523 PF15023.6 AET40301.1 - 0.0013 18.6 0.0 0.67 9.8 0.0 3.2 2 1 1 3 3 3 1 Protein of unknown function (DUF4523) NleF_casp_inhib PF16809.5 AET40301.1 - 0.012 15.6 0.5 0.03 14.2 0.5 1.6 1 0 0 1 1 1 0 NleF caspase inhibitor Nup35_RRM_2 PF14605.6 AET40301.1 - 0.017 15.1 0.3 18 5.4 0.0 3.9 5 0 0 5 5 5 0 Nup53/35/40-type RNA recognition motif SET_assoc PF11767.8 AET40301.1 - 0.022 14.4 0.1 55 3.5 0.0 3.9 4 0 0 4 4 4 0 Histone lysine methyltransferase SET associated YflT PF11181.8 AET40301.1 - 0.29 11.7 13.8 3 8.4 0.4 3.7 3 1 1 4 4 3 0 Heat induced stress protein YflT PNPase PF03726.14 AET40301.1 - 0.35 11.4 5.8 0.22 12.1 0.3 3.1 3 0 0 3 3 3 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain UQ_con PF00179.26 AET40302.1 - 7.1e-47 158.6 0.0 8.3e-47 158.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AET40302.1 - 0.0025 17.5 0.0 0.0033 17.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 AET40302.1 - 0.021 14.7 0.1 0.041 13.7 0.1 1.4 1 1 0 1 1 1 0 UEV domain Prok-E2_A PF14457.6 AET40302.1 - 0.037 13.7 0.1 0.12 12.0 0.1 1.8 1 1 0 1 1 1 0 Prokaryotic E2 family A RWD PF05773.22 AET40302.1 - 0.062 13.6 0.0 0.084 13.2 0.0 1.3 1 0 0 1 1 1 0 RWD domain PhoLip_ATPase_C PF16212.5 AET40303.1 - 1.7e-79 267.1 33.0 1.7e-79 267.1 33.0 2.5 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 AET40303.1 - 3.7e-20 71.4 0.7 1.1e-19 69.9 0.7 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 AET40303.1 - 5.8e-12 45.5 0.0 2.4e-11 43.6 0.0 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 AET40303.1 - 6.4e-09 36.4 3.3 0.00017 22.0 0.6 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 AET40303.1 - 6.1e-05 22.6 0.0 6.1e-05 22.6 0.0 2.6 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 AET40303.1 - 0.0048 16.7 0.3 0.0048 16.7 0.3 2.4 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase PolyA_pol PF01743.20 AET40304.1 - 2.3e-25 89.4 0.0 4e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 AET40304.1 - 1.9e-07 30.7 0.0 4.7e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 AET40304.1 - 0.015 15.3 0.0 0.028 14.4 0.0 1.5 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative MPC PF03650.13 AET40305.1 - 5.7e-48 161.6 0.1 6.4e-48 161.5 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers ATP-grasp_2 PF08442.10 AET40306.1 - 1.8e-72 243.1 1.0 2.9e-72 242.5 1.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 AET40306.1 - 4.3e-25 88.3 0.3 1.8e-24 86.3 0.1 2.2 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_5 PF13549.6 AET40306.1 - 7e-07 28.9 0.2 1.2e-06 28.1 0.2 1.3 1 0 0 1 1 1 1 ATP-grasp domain SDA1 PF05285.12 AET40307.1 - 4.3e-92 309.2 32.6 2.6e-91 306.7 28.9 2.2 2 0 0 2 2 2 2 SDA1 NUC130_3NT PF08158.12 AET40307.1 - 9.4e-19 67.5 0.2 2.6e-18 66.1 0.2 1.8 1 0 0 1 1 1 1 NUC130/3NT domain YL1 PF05764.13 AET40307.1 - 0.035 14.2 29.1 0.18 11.9 21.1 2.4 2 0 0 2 2 2 0 YL1 nuclear protein TFIIB PF00382.19 AET40308.1 - 2.5e-56 187.6 0.8 1.8e-28 98.4 0.1 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 AET40308.1 - 9e-30 103.0 0.0 9e-30 103.0 0.0 2.5 2 1 0 2 2 2 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 AET40308.1 - 3.2e-13 48.9 3.2 5.8e-13 48.1 3.2 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 AET40308.1 - 0.00037 20.2 0.3 0.67 9.7 0.1 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Zn-ribbon_8 PF09723.10 AET40308.1 - 0.17 12.0 1.4 0.39 10.9 1.4 1.6 1 0 0 1 1 1 0 Zinc ribbon domain OrfB_Zn_ribbon PF07282.11 AET40308.1 - 0.31 11.0 1.5 0.69 9.9 1.5 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Vps36-NZF-N PF16988.5 AET40308.1 - 1.3 8.5 3.9 14 5.1 3.1 2.4 1 1 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain CPDase PF07823.11 AET40309.1 - 5e-74 248.3 0.0 5.9e-74 248.1 0.0 1.1 1 0 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.6 AET40309.1 - 0.00035 20.5 0.0 0.45 10.4 0.0 2.1 2 0 0 2 2 2 2 2'-5' RNA ligase superfamily Glucosamine_iso PF01182.20 AET40310.1 - 4.5e-58 196.8 0.0 5.1e-58 196.6 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase HSF_DNA-bind PF00447.17 AET40311.1 - 1.1e-21 77.2 0.0 1.1e-21 77.2 0.0 2.1 2 0 0 2 2 1 1 HSF-type DNA-binding Peptidase_S49_N PF08496.10 AET40311.1 - 0.53 10.3 2.1 1.2 9.2 2.1 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Synuclein PF01387.17 AET40311.1 - 0.61 10.3 2.0 1.3 9.3 2.0 1.4 1 0 0 1 1 1 0 Synuclein YABBY PF04690.13 AET40311.1 - 1.7 9.2 10.7 0.76 10.3 7.7 2.0 2 0 0 2 2 2 0 YABBY protein DUF4175 PF13779.6 AET40311.1 - 2.4 6.0 21.7 3.3 5.5 21.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) EIIBC-GUT_N PF03612.14 AET40311.1 - 2.6 7.8 4.7 4.7 6.9 4.7 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus PepSY_TM PF03929.16 AET40311.1 - 3 7.4 8.4 13 5.4 5.2 2.5 2 0 0 2 2 2 0 PepSY-associated TM region EOS1 PF12326.8 AET40311.1 - 3.8 7.4 5.5 10 6.0 5.5 1.7 1 0 0 1 1 1 0 N-glycosylation protein CPSF100_C PF13299.6 AET40311.1 - 4.7 7.4 7.5 9.9 6.3 7.5 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Menin PF05053.13 AET40311.1 - 4.7 5.4 7.6 6.8 4.9 7.6 1.2 1 0 0 1 1 1 0 Menin Ctr PF04145.15 AET40311.1 - 5.5 7.6 8.3 0.68 10.6 3.6 1.9 2 0 0 2 2 2 0 Ctr copper transporter family Tim54 PF11711.8 AET40311.1 - 8.4 5.1 10.8 14 4.4 10.8 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RRM_1 PF00076.22 AET40312.1 - 3.7e-35 119.6 0.1 7.2e-15 54.6 0.0 5.5 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 AET40312.1 - 0.0037 17.2 0.0 8.4 6.5 0.0 3.5 3 0 0 3 3 3 1 RNA binding domain RRM_7 PF16367.5 AET40312.1 - 0.15 12.2 0.3 26 5.0 0.0 3.5 3 1 0 3 3 3 0 RNA recognition motif Dna2 PF08696.11 AET40313.1 - 3.8e-57 193.4 1.0 8.2e-57 192.3 1.0 1.6 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.6 AET40313.1 - 4.2e-50 170.2 0.0 8.5e-50 169.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 AET40313.1 - 1.6e-31 110.1 7.7 6.1e-17 62.3 0.0 3.6 4 1 1 5 5 5 2 AAA domain AAA_30 PF13604.6 AET40313.1 - 3.3e-14 53.1 0.0 6.5e-14 52.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AET40313.1 - 1.8e-10 41.4 0.0 3.6e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain PDDEXK_1 PF12705.7 AET40313.1 - 2.6e-06 27.6 0.0 4.5e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Viral_helicase1 PF01443.18 AET40313.1 - 8.4e-06 25.7 0.3 0.88 9.3 0.0 3.7 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase Cas_Cas4 PF01930.17 AET40313.1 - 6.1e-05 23.2 0.4 0.00037 20.6 0.2 2.5 1 1 0 2 2 2 1 Domain of unknown function DUF83 SRP54 PF00448.22 AET40313.1 - 0.00037 20.2 0.1 0.00077 19.1 0.1 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 AET40313.1 - 0.00066 20.1 0.0 0.0015 18.9 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain CbiA PF01656.23 AET40313.1 - 0.0048 17.0 0.4 0.018 15.1 0.4 1.9 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_18 PF13238.6 AET40313.1 - 0.014 16.0 0.0 0.05 14.1 0.0 2.0 1 0 0 1 1 1 0 AAA domain Helicase_RecD PF05127.14 AET40313.1 - 0.016 15.1 0.0 0.044 13.6 0.0 1.8 1 0 0 1 1 1 0 Helicase ResIII PF04851.15 AET40313.1 - 0.017 15.2 1.3 0.064 13.3 0.1 2.6 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit PIF1 PF05970.14 AET40313.1 - 0.017 14.3 0.0 0.79 8.8 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase NTPase_1 PF03266.15 AET40313.1 - 0.021 14.8 0.6 0.28 11.1 0.3 2.8 2 0 0 2 2 2 0 NTPase AAA_5 PF07728.14 AET40313.1 - 0.028 14.4 0.1 0.12 12.3 0.1 2.1 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) MobB PF03205.14 AET40313.1 - 0.033 14.1 0.1 0.083 12.8 0.1 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_7 PF12775.7 AET40313.1 - 0.034 13.6 0.0 0.078 12.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 AET40313.1 - 0.061 13.5 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 AET40313.1 - 0.062 13.1 0.4 0.2 11.4 0.1 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA PF00004.29 AET40313.1 - 0.072 13.5 0.0 0.21 12.0 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) UvrD-helicase PF00580.21 AET40313.1 - 0.083 12.4 0.0 0.083 12.4 0.0 3.1 3 1 0 3 3 2 0 UvrD/REP helicase N-terminal domain T2SSE PF00437.20 AET40313.1 - 0.11 11.5 0.0 0.3 10.1 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2075 PF09848.9 AET40313.1 - 0.13 11.5 0.0 0.41 9.8 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) MeaB PF03308.16 AET40313.1 - 0.15 11.0 0.0 0.28 10.1 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB PalH PF08733.10 AET40314.1 - 1.3e-87 293.9 21.4 1.6e-87 293.6 21.4 1.1 1 0 0 1 1 1 1 PalH/RIM21 Yip1 PF04893.17 AET40314.1 - 0.0049 16.6 7.6 0.31 10.7 2.7 2.6 2 1 0 2 2 2 2 Yip1 domain DUF808 PF05661.12 AET40314.1 - 0.08 12.0 0.4 0.13 11.3 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF808) DUF2142 PF09913.9 AET40314.1 - 0.44 9.4 17.6 0.062 12.2 7.2 2.3 1 1 1 2 2 2 0 Predicted membrane protein (DUF2142) HXXEE PF13787.6 AET40314.1 - 0.83 10.5 19.2 1.4 9.7 0.3 3.5 2 1 0 2 2 2 0 Protein of unknown function with HXXEE motif Abhydrolase_1 PF00561.20 AET40315.1 - 2e-25 89.9 0.0 8.2e-25 87.9 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AET40315.1 - 8.4e-15 56.0 0.0 1.9e-14 54.8 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AET40315.1 - 5.7e-14 52.0 0.0 1.3e-12 47.5 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 LIDHydrolase PF10230.9 AET40315.1 - 1.5e-05 24.7 0.0 2.8e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Ndr PF03096.14 AET40315.1 - 3e-05 22.9 0.0 0.00011 21.0 0.0 1.9 2 0 0 2 2 2 1 Ndr family Abhydrolase_5 PF12695.7 AET40315.1 - 0.00018 21.3 0.0 0.00044 20.1 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 AET40315.1 - 0.001 18.9 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase Abhydrolase_3 PF07859.13 AET40315.1 - 0.0019 18.1 0.0 0.015 15.2 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Esterase PF00756.20 AET40315.1 - 0.002 17.8 0.0 0.0031 17.2 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Lipase_3 PF01764.25 AET40315.1 - 0.0086 15.9 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Peptidase_S9 PF00326.21 AET40315.1 - 0.015 14.8 0.0 0.15 11.5 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family UPF0227 PF05728.12 AET40315.1 - 0.041 13.8 0.0 0.098 12.6 0.0 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) PGAP1 PF07819.13 AET40315.1 - 0.041 13.6 0.0 0.07 12.8 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DLH PF01738.18 AET40315.1 - 0.12 11.9 0.0 0.64 9.5 0.0 1.9 2 0 0 2 2 2 0 Dienelactone hydrolase family Cellulase PF00150.18 AET40316.1 - 5.1e-13 49.1 4.2 5.1e-13 49.1 4.2 2.1 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) bZIP_1 PF00170.21 AET40318.1 - 1.4e-08 34.7 17.1 3e-07 30.4 17.1 2.3 1 1 0 1 1 1 1 bZIP transcription factor TFIIA PF03153.13 AET40318.1 - 1.9 8.4 15.3 2.5 8.0 15.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AAA_2 PF07724.14 AET40319.1 - 8.3e-51 172.5 0.0 2e-48 164.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 AET40319.1 - 1.5e-35 121.2 0.7 1.5e-35 121.2 0.7 2.7 1 1 0 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 AET40319.1 - 1.1e-26 92.7 2.1 2.3e-26 91.6 0.3 2.4 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 AET40319.1 - 8.5e-22 78.0 0.0 6.3e-11 42.8 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AET40319.1 - 7.5e-17 61.6 0.2 1.6e-11 44.3 0.0 3.8 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AET40319.1 - 4.8e-11 43.3 1.7 0.00035 21.0 0.1 3.9 3 2 1 5 5 3 2 AAA ATPase domain Sigma54_activat PF00158.26 AET40319.1 - 1.7e-07 31.1 0.1 3.2e-05 23.7 0.0 2.5 2 1 0 2 2 2 1 Sigma-54 interaction domain ATPase_2 PF01637.18 AET40319.1 - 8.8e-07 29.1 5.1 0.28 11.1 0.1 4.1 4 1 0 4 4 4 2 ATPase domain predominantly from Archaea AAA_22 PF13401.6 AET40319.1 - 1.1e-06 29.0 0.2 0.037 14.3 0.1 3.3 2 2 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 AET40319.1 - 1.5e-06 28.1 0.0 0.024 14.4 0.0 2.8 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_14 PF13173.6 AET40319.1 - 7.4e-06 26.0 0.0 0.056 13.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 AET40319.1 - 8.2e-06 25.5 0.2 0.035 13.6 0.0 3.0 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_18 PF13238.6 AET40319.1 - 1e-05 26.1 0.5 0.44 11.1 0.0 3.6 3 0 0 3 3 3 2 AAA domain TniB PF05621.11 AET40319.1 - 1.9e-05 24.2 0.1 0.0065 15.9 0.0 3.4 2 1 0 2 2 2 1 Bacterial TniB protein NACHT PF05729.12 AET40319.1 - 6.9e-05 22.8 0.0 0.09 12.7 0.0 2.5 2 0 0 2 2 2 1 NACHT domain TsaE PF02367.17 AET40319.1 - 0.00013 21.9 0.0 0.64 10.0 0.0 2.6 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_21 PF13304.6 AET40319.1 - 0.00018 21.4 0.2 0.46 10.2 0.0 3.6 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.27 AET40319.1 - 0.00018 22.0 1.1 0.37 11.3 0.0 3.5 3 0 0 3 3 3 1 ABC transporter RsgA_GTPase PF03193.16 AET40319.1 - 0.00019 21.4 1.2 0.042 13.8 0.1 3.0 3 0 0 3 3 2 1 RsgA GTPase AAA_28 PF13521.6 AET40319.1 - 0.0003 21.1 0.0 0.35 11.1 0.0 3.2 3 0 0 3 3 2 1 AAA domain AAA_30 PF13604.6 AET40319.1 - 0.00033 20.5 0.0 0.25 11.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 AET40319.1 - 0.00042 20.7 0.1 1 9.8 0.0 3.2 2 1 0 2 2 2 1 RNA helicase AAA_29 PF13555.6 AET40319.1 - 0.00044 19.9 0.0 0.17 11.6 0.0 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain Roc PF08477.13 AET40319.1 - 0.00078 19.7 0.0 1.1 9.5 0.0 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase DUF815 PF05673.13 AET40319.1 - 0.00081 18.6 0.9 0.51 9.5 0.3 3.6 2 2 0 2 2 2 1 Protein of unknown function (DUF815) PduV-EutP PF10662.9 AET40319.1 - 0.00082 19.1 0.0 0.38 10.5 0.0 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_6 PF12774.7 AET40319.1 - 0.0015 17.5 0.2 0.058 12.4 0.0 3.0 3 1 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region ResIII PF04851.15 AET40319.1 - 0.0023 17.9 0.2 0.82 9.6 0.0 3.6 3 1 1 4 4 3 1 Type III restriction enzyme, res subunit Zeta_toxin PF06414.12 AET40319.1 - 0.0037 16.6 0.0 0.059 12.6 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin Mg_chelatase PF01078.21 AET40319.1 - 0.0044 16.4 0.2 0.96 8.8 0.0 3.1 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI SRP54 PF00448.22 AET40319.1 - 0.0062 16.2 0.0 1.9 8.1 0.0 2.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_25 PF13481.6 AET40319.1 - 0.012 15.2 0.0 0.58 9.7 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA_19 PF13245.6 AET40319.1 - 0.012 16.0 1.4 6.5 7.1 0.3 3.8 2 2 0 2 2 2 0 AAA domain AAA_33 PF13671.6 AET40319.1 - 0.015 15.5 0.1 4 7.6 0.0 3.1 3 0 0 3 3 3 0 AAA domain ATP_bind_1 PF03029.17 AET40319.1 - 0.027 14.3 0.0 4.7 6.9 0.0 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein PhoH PF02562.16 AET40319.1 - 0.033 13.7 0.0 2 7.8 0.0 2.6 2 0 0 2 2 2 0 PhoH-like protein MMR_HSR1 PF01926.23 AET40319.1 - 0.034 14.2 0.3 3.1 7.9 0.1 3.4 2 2 0 2 2 2 0 50S ribosome-binding GTPase DUF87 PF01935.17 AET40319.1 - 0.035 14.2 4.0 4.9 7.2 0.0 3.6 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_3 PF07726.11 AET40319.1 - 0.052 13.4 0.1 0.94 9.4 0.0 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Torsin PF06309.11 AET40319.1 - 0.06 13.5 0.0 0.29 11.2 0.0 2.0 2 0 0 2 2 2 0 Torsin RuvB_N PF05496.12 AET40319.1 - 0.062 13.0 0.1 9.8 5.9 0.0 3.2 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 AET40319.1 - 0.066 12.9 0.0 11 5.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain LacI PF00356.21 AET40319.1 - 0.088 12.6 0.0 6.2 6.7 0.0 2.7 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family HIP1_clath_bdg PF16515.5 AET40319.1 - 0.11 13.1 6.1 0.42 11.3 6.1 2.0 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 AAA_23 PF13476.6 AET40319.1 - 0.7 10.4 18.9 1.4 9.4 0.2 4.4 3 2 1 4 4 2 0 AAA domain V-SNARE PF05008.15 AET40319.1 - 4.3 7.8 8.1 0.69 10.3 2.4 2.7 4 0 0 4 4 1 0 Vesicle transport v-SNARE protein N-terminus TPR_1 PF00515.28 AET40320.1 - 3.3e-42 140.6 25.6 4.1e-09 35.9 0.1 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 AET40320.1 - 9.6e-36 119.0 23.7 1.3e-07 31.1 0.2 9.3 9 0 0 9 9 9 8 Tetratricopeptide repeat STI1 PF17830.1 AET40320.1 - 2.3e-34 117.1 15.5 2.8e-17 62.4 2.0 2.7 2 0 0 2 2 2 2 STI1 domain TPR_11 PF13414.6 AET40320.1 - 1.9e-18 65.9 28.4 0.0037 16.9 0.6 8.4 6 2 2 8 8 8 6 TPR repeat TPR_12 PF13424.6 AET40320.1 - 1.4e-17 63.7 18.2 1.8e-08 34.5 2.1 5.8 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 AET40320.1 - 4.2e-17 60.9 28.1 4.8e-06 26.4 0.1 8.4 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_14 PF13428.6 AET40320.1 - 2e-15 56.2 7.6 0.013 16.3 0.1 8.3 5 3 3 8 8 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 AET40320.1 - 8.9e-15 55.1 16.5 0.023 15.3 1.2 6.5 4 3 2 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 AET40320.1 - 2.5e-14 53.5 20.5 0.0021 18.6 0.1 7.1 4 3 4 8 8 8 5 Tetratricopeptide repeat TPR_10 PF13374.6 AET40320.1 - 1.1e-12 47.4 14.6 0.015 15.1 0.0 6.9 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 AET40320.1 - 1.2e-11 43.8 14.8 0.00056 19.8 0.0 7.4 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_9 PF13371.6 AET40320.1 - 7.7e-07 29.2 4.7 0.0011 19.1 0.0 4.7 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 AET40320.1 - 3.4e-06 27.1 7.6 0.36 11.3 0.0 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AET40320.1 - 0.00048 20.3 15.2 0.77 10.0 2.4 5.4 3 3 3 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.9 AET40320.1 - 0.00063 19.5 17.3 0.18 11.5 0.2 5.4 2 2 3 5 5 5 2 26S proteasome subunit RPN7 SHNi-TPR PF10516.9 AET40320.1 - 0.0014 18.1 10.5 0.45 10.0 0.1 6.1 7 0 0 7 7 7 1 SHNi-TPR TPR_6 PF13174.6 AET40320.1 - 0.0048 17.5 22.0 0.52 11.1 0.1 7.7 8 0 0 8 8 7 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 AET40320.1 - 0.039 14.0 7.5 4.7 7.4 0.2 5.3 6 0 0 6 6 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.6 AET40320.1 - 0.045 14.1 9.0 4.5 7.7 0.0 4.7 4 2 0 4 4 4 0 Tetratricopeptide repeat PPR_2 PF13041.6 AET40320.1 - 0.27 11.5 2.7 47 4.3 0.0 4.6 5 0 0 5 5 5 0 PPR repeat family PPR PF01535.20 AET40320.1 - 2 8.8 10.2 62 4.2 0.1 6.2 8 0 0 8 8 6 0 PPR repeat MIT PF04212.18 AET40320.1 - 3.5 7.7 19.1 29 4.8 0.2 6.7 7 0 0 7 7 7 0 MIT (microtubule interacting and transport) domain SET PF00856.28 AET40321.1 - 1.6e-13 51.4 0.1 4.8e-13 49.8 0.0 1.8 2 1 0 2 2 2 1 SET domain WD40 PF00400.32 AET40322.1 - 5.8e-08 33.3 1.1 0.00019 22.2 0.0 3.9 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET40322.1 - 0.00083 19.6 0.2 2.9 8.2 0.0 4.4 2 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 AET40322.1 - 0.035 12.4 0.4 0.21 9.9 0.1 2.2 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz BBS2_N PF14781.6 AET40322.1 - 0.046 13.6 0.2 0.34 10.8 0.0 2.4 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, N-terminal Cu-oxidase_2 PF07731.14 AET40322.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Multicopper oxidase Pex24p PF06398.11 AET40323.1 - 1e-76 258.3 8.0 1.3e-76 258.0 8.0 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF799 PF05643.11 AET40323.1 - 0.07 12.7 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Putative bacterial lipoprotein (DUF799) DUF4241 PF14025.6 AET40323.1 - 0.11 12.8 0.1 0.19 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4241) Rpr2 PF04032.16 AET40324.1 - 9.1e-12 45.1 1.4 2.9e-11 43.5 0.0 2.1 2 0 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF4080 PF13311.6 AET40324.1 - 0.015 15.5 0.1 0.016 15.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4080) SIR2 PF02146.17 AET40325.1 - 5.7e-38 130.6 0.0 1.1e-36 126.4 0.0 2.4 1 1 0 1 1 1 1 Sir2 family DUF2256 PF10013.9 AET40325.1 - 0.026 14.7 0.3 0.066 13.3 0.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) Zn-ribbon_8 PF09723.10 AET40325.1 - 0.14 12.3 1.2 0.43 10.7 0.4 2.2 2 0 0 2 2 2 0 Zinc ribbon domain Pkinase PF00069.25 AET40326.1 - 8.8e-76 254.7 0.1 1.4e-75 254.1 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain AdenylateSensor PF16579.5 AET40326.1 - 1.1e-58 196.8 0.3 3.4e-57 192.0 0.1 2.7 2 0 0 2 2 2 1 Adenylate sensor of SNF1-like protein kinase Pkinase_Tyr PF07714.17 AET40326.1 - 4.3e-38 131.1 0.0 6.7e-38 130.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase UBA_2 PF08587.11 AET40326.1 - 6.8e-19 67.7 3.4 6.8e-19 67.7 3.4 2.2 2 0 0 2 2 2 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 AET40326.1 - 1.4e-09 37.7 0.0 3.7e-09 36.3 0.0 1.7 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 AET40326.1 - 8.6e-05 22.2 0.5 0.00019 21.1 0.5 1.6 1 0 0 1 1 1 1 RIO1 family YukC PF10140.9 AET40326.1 - 0.00016 20.6 0.6 0.0003 19.7 0.6 1.4 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC Haspin_kinase PF12330.8 AET40326.1 - 0.00027 20.0 0.6 0.00047 19.2 0.6 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 AET40326.1 - 0.0032 16.8 0.2 0.0063 15.9 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AET40326.1 - 0.028 14.4 0.2 0.66 9.9 0.2 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF2470 PF10615.9 AET40327.1 - 6e-19 68.5 0.3 8.6e-19 67.9 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) Adeno_E3_CR2 PF02439.15 AET40327.1 - 0.055 13.2 0.3 2 8.2 0.0 2.3 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 APP_E2 PF12925.7 AET40327.1 - 0.8 9.4 2.5 2.6 7.7 0.3 2.0 1 1 1 2 2 2 0 E2 domain of amyloid precursor protein SDA1 PF05285.12 AET40328.1 - 0.25 10.7 10.7 0.47 9.8 10.7 1.4 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 AET40328.1 - 0.81 7.9 9.6 1.6 6.9 9.6 1.4 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 AET40328.1 - 3.1 5.8 16.8 4.7 5.2 16.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF4611 PF15387.6 AET40328.1 - 6 7.2 12.8 1.9 8.8 8.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) RRN3 PF05327.11 AET40328.1 - 8.2 4.8 12.1 12 4.2 12.1 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2457 PF10446.9 AET40328.1 - 9.9 5.2 25.2 0.56 9.3 17.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) PRP3 PF08572.10 AET40329.1 - 8.2e-56 189.2 21.1 8.2e-56 189.2 21.1 1.5 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 AET40329.1 - 6.4e-31 107.4 0.2 6.4e-31 107.4 0.2 3.6 3 1 1 4 4 4 1 Protein of unknown function (DUF1115) Cpn10 PF00166.21 AET40330.1 - 2.3e-28 98.1 0.1 2.5e-28 97.9 0.1 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit ATP19 PF11022.8 AET40331.1 - 2e-19 69.7 0.1 2.2e-19 69.6 0.1 1.0 1 0 0 1 1 1 1 ATP synthase subunit K RNA_Me_trans PF04252.13 AET40332.1 - 8.8e-78 260.5 0.0 9.8e-78 260.3 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase DDHD PF02862.17 AET40333.1 - 2.1e-36 126.1 1.2 8.6e-26 91.5 0.1 2.8 2 1 1 3 3 3 2 DDHD domain LCAT PF02450.15 AET40333.1 - 2.6e-07 30.2 0.0 7.7e-06 25.3 0.0 2.2 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase DUF676 PF05057.14 AET40333.1 - 2e-05 24.2 0.0 0.0035 16.9 0.0 2.4 2 0 0 2 2 2 2 Putative serine esterase (DUF676) Palm_thioest PF02089.15 AET40333.1 - 6.8e-05 22.8 0.0 0.00022 21.1 0.0 1.8 2 1 0 2 2 2 1 Palmitoyl protein thioesterase WWE PF02825.20 AET40333.1 - 0.023 15.3 0.2 0.1 13.2 0.0 2.3 2 0 0 2 2 2 0 WWE domain PGAP1 PF07819.13 AET40333.1 - 0.059 13.1 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_6 PF12697.7 AET40333.1 - 0.18 12.4 0.0 0.3 11.7 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF1890 PF09001.11 AET40334.1 - 0.15 12.5 0.3 0.31 11.4 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1890) 4F5 PF04419.14 AET40335.1 - 5e-10 40.1 8.9 5e-10 40.1 8.9 2.6 2 1 0 2 2 2 1 4F5 protein family WD40 PF00400.32 AET40336.1 - 2.3e-17 63.0 4.7 0.01 16.7 0.1 6.7 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET40336.1 - 1.4e-08 34.9 0.1 0.0014 18.9 0.0 4.7 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 AET40336.1 - 0.0044 16.6 0.1 0.052 13.1 0.1 2.2 1 1 0 1 1 1 1 PQQ-like domain RAB3GAP2_N PF14655.6 AET40336.1 - 0.049 12.9 0.1 0.23 10.7 0.0 1.9 1 1 1 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus PQQ_3 PF13570.6 AET40336.1 - 0.32 11.5 4.8 0.96 10.0 0.1 3.6 3 1 1 4 4 4 0 PQQ-like domain DLH PF01738.18 AET40337.1 - 7.5e-22 77.9 0.0 9.6e-22 77.6 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 AET40337.1 - 0.009 15.5 0.1 0.02 14.4 0.0 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family LIDHydrolase PF10230.9 AET40337.1 - 0.025 14.1 0.0 0.036 13.6 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase BAAT_C PF08840.11 AET40337.1 - 0.086 12.8 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Osw5 PF17062.5 AET40339.1 - 4.2e-22 78.0 9.0 5.7e-22 77.6 9.0 1.2 1 0 0 1 1 1 1 Outer spore wall 5 DUF1682 PF07946.14 AET40339.1 - 0.8 8.8 4.3 1.1 8.4 4.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Ribophorin_II PF05817.14 AET40340.1 - 2.8e-08 32.8 0.7 3.5e-08 32.5 0.7 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II Peptidase_S24 PF00717.23 AET40341.1 - 3.8e-06 26.8 0.1 2.3e-05 24.3 0.1 2.2 2 0 0 2 2 2 1 Peptidase S24-like Peptidase_S26 PF10502.9 AET40341.1 - 0.00028 20.7 0.0 0.00042 20.1 0.0 1.3 1 0 0 1 1 1 1 Signal peptidase, peptidase S26 adh_short PF00106.25 AET40342.1 - 1.5e-09 37.6 0.0 1.9e-08 34.0 0.0 2.3 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 AET40342.1 - 0.0023 17.5 0.0 0.0038 16.8 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase LUC7 PF03194.15 AET40343.1 - 5.7e-57 193.3 6.1 7e-57 193.0 6.1 1.0 1 0 0 1 1 1 1 LUC7 N_terminus EzrA PF06160.12 AET40343.1 - 0.0088 14.3 4.4 0.0068 14.6 3.0 1.5 2 0 0 2 2 2 1 Septation ring formation regulator, EzrA DUF4686 PF15742.5 AET40343.1 - 0.016 14.4 7.8 0.046 12.8 7.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4686) DnaG_DnaB_bind PF08278.11 AET40343.1 - 0.098 13.3 2.7 0.1 13.2 1.0 1.9 2 0 0 2 2 2 0 DNA primase DnaG DnaB-binding Med4 PF10018.9 AET40343.1 - 0.72 9.5 5.5 1.2 8.7 0.6 2.4 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 FlaC_arch PF05377.11 AET40343.1 - 2.2 8.7 5.9 1.3 9.5 0.3 3.3 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Nup35_RRM PF05172.13 AET40344.1 - 3.1e-32 110.6 0.1 8.3e-32 109.2 0.0 1.8 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 AET40344.1 - 0.002 18.1 0.2 0.01 15.8 0.0 2.3 2 1 0 2 2 2 1 Nup53/35/40-type RNA recognition motif GATase_6 PF13522.6 AET40344.1 - 0.014 15.6 0.1 0.029 14.6 0.1 1.4 1 0 0 1 1 1 0 Glutamine amidotransferase domain Copper-bind PF00127.20 AET40344.1 - 0.087 13.3 1.2 0.24 11.8 1.2 1.7 1 0 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family DUF2418 PF10332.9 AET40345.1 - 8.4e-22 77.5 1.3 8.4e-22 77.5 1.3 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF2418) DUF1106 PF06523.11 AET40346.1 - 0.076 13.1 2.4 0.45 10.6 0.2 3.2 3 1 1 4 4 4 0 Protein of unknown function (DUF1106) Prenyltrans PF00432.21 AET40347.1 - 1.1e-32 111.4 2.6 2.9e-12 46.1 0.3 5.6 5 1 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat APP_N PF02177.16 AET40347.1 - 0.18 12.2 0.7 0.42 11.0 0.2 1.8 2 0 0 2 2 2 0 Amyloid A4 N-terminal heparin-binding UBX PF00789.20 AET40348.1 - 3.6e-15 55.9 0.0 1.4e-14 54.0 0.0 2.0 2 0 0 2 2 2 1 UBX domain SMP_2 PF10144.9 AET40348.1 - 0.012 15.3 1.3 0.2 11.3 0.0 2.4 2 0 0 2 2 2 0 Bacterial virulence factor haemolysin SRP14 PF02290.15 AET40349.1 - 8.2e-19 67.8 1.0 1.3e-18 67.1 0.0 1.7 1 1 1 2 2 2 1 Signal recognition particle 14kD protein DUF325 PF03804.13 AET40349.1 - 0.096 12.7 0.2 0.53 10.3 0.2 2.1 1 1 0 1 1 1 0 Viral proteins of unknown function Nodulin-like PF06813.13 AET40350.1 - 4e-12 46.2 1.7 4e-12 46.2 1.7 2.6 2 1 0 2 2 2 1 Nodulin-like DUF5510 PF17629.2 AET40350.1 - 0.06 13.3 2.4 0.18 11.7 2.4 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5510) PMT PF02366.18 AET40351.1 - 1.4e-85 286.8 18.1 2.9e-85 285.8 18.1 1.6 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 AET40351.1 - 6.9e-61 205.3 17.3 6.9e-61 205.3 17.3 1.9 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 AET40351.1 - 2.5e-51 174.2 0.8 4.5e-51 173.4 0.8 1.3 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 AET40351.1 - 9.7e-05 22.6 13.0 9.7e-05 22.6 13.0 3.2 3 1 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase RPN6_N PF18055.1 AET40352.1 - 2.1e-38 131.2 2.6 2.1e-38 131.2 2.6 2.8 3 1 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 AET40352.1 - 2.2e-18 66.7 0.1 1.2e-17 64.3 0.0 2.4 2 0 0 2 2 2 1 PCI domain RPN6_C_helix PF18503.1 AET40352.1 - 3.6e-12 45.8 0.1 8e-12 44.7 0.1 1.6 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_12 PF13424.6 AET40352.1 - 0.0081 16.4 8.1 0.64 10.3 0.5 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat DDRGK PF09756.9 AET40352.1 - 0.032 13.8 0.1 0.078 12.6 0.1 1.6 1 0 0 1 1 1 0 DDRGK domain TPR_MalT PF17874.1 AET40352.1 - 0.057 12.8 1.4 0.079 12.3 0.7 1.6 1 1 0 1 1 1 0 MalT-like TPR region TPR_16 PF13432.6 AET40352.1 - 0.14 12.9 2.1 1.9 9.2 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat SbsC_C PF18058.1 AET40352.1 - 4.9 7.4 7.5 0.42 10.8 1.7 2.1 2 0 0 2 2 2 0 SbsC C-terminal domain zf-met PF12874.7 AET40353.1 - 6.3e-06 26.4 0.6 1.4e-05 25.3 0.6 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AET40353.1 - 4.9e-05 23.5 1.0 4.9e-05 23.5 1.0 2.0 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 AET40353.1 - 0.045 14.1 1.1 0.077 13.3 1.1 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) SNRNP27 PF08648.12 AET40353.1 - 0.047 13.8 1.6 0.055 13.5 0.1 1.9 2 0 0 2 2 2 0 U4/U6.U5 small nuclear ribonucleoproteins zf-C2H2 PF00096.26 AET40353.1 - 0.088 13.3 1.5 0.25 11.9 1.5 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AET40353.1 - 0.13 13.1 0.5 0.35 11.8 0.5 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger Methyltransf_2 PF00891.18 AET40354.1 - 0.03 13.6 0.0 0.099 11.9 0.0 1.8 2 0 0 2 2 2 0 O-methyltransferase domain Ribosomal_S8 PF00410.19 AET40355.1 - 2.3e-10 40.5 0.0 1.5e-09 37.8 0.0 1.9 1 1 0 1 1 1 1 Ribosomal protein S8 DUF848 PF05852.11 AET40356.1 - 9.2e-05 22.6 4.6 9.2e-05 22.6 4.6 2.3 2 0 0 2 2 2 1 Gammaherpesvirus protein of unknown function (DUF848) Tho2 PF11262.8 AET40356.1 - 0.00018 20.8 2.3 0.00018 20.8 2.3 2.1 2 0 0 2 2 2 1 Transcription factor/nuclear export subunit protein 2 Lebercilin PF15619.6 AET40356.1 - 0.00068 19.3 4.4 0.00068 19.3 4.4 2.3 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease MscS_porin PF12795.7 AET40356.1 - 0.0011 18.6 8.9 0.0011 18.6 8.9 2.2 2 0 0 2 2 2 1 Mechanosensitive ion channel porin domain SlyX PF04102.12 AET40356.1 - 0.0019 18.7 17.2 0.0029 18.2 2.0 3.4 2 1 1 3 3 3 1 SlyX TMF_DNA_bd PF12329.8 AET40356.1 - 0.002 18.1 13.9 0.002 18.1 13.9 2.7 3 0 0 3 3 2 1 TATA element modulatory factor 1 DNA binding Tropomyosin_1 PF12718.7 AET40356.1 - 0.0078 16.4 6.6 0.0078 16.4 6.6 2.3 2 1 0 2 2 2 1 Tropomyosin like ACCA PF03255.14 AET40356.1 - 0.02 14.8 1.8 0.02 14.8 1.8 3.1 2 1 2 4 4 4 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit ZapB PF06005.12 AET40356.1 - 0.1 13.1 19.8 0.16 12.4 6.9 2.5 2 0 0 2 2 2 0 Cell division protein ZapB DUF148 PF02520.17 AET40356.1 - 0.16 12.0 23.8 0.29 11.2 5.8 3.2 1 1 1 3 3 3 0 Domain of unknown function DUF148 LPP PF04728.13 AET40356.1 - 0.21 12.0 8.0 0.84 10.1 1.5 3.1 1 1 1 2 2 2 0 Lipoprotein leucine-zipper Seryl_tRNA_N PF02403.22 AET40356.1 - 0.21 11.8 17.8 0.14 12.4 6.0 2.5 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FlxA PF14282.6 AET40356.1 - 0.32 11.0 27.4 0.22 11.6 15.4 2.8 2 1 0 2 2 2 0 FlxA-like protein DASH_Hsk3 PF08227.11 AET40356.1 - 0.33 11.3 1.9 6.9 7.1 0.2 2.5 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like YvrJ PF12841.7 AET40356.1 - 0.66 9.5 4.1 4.9 6.8 1.0 2.5 2 0 0 2 2 2 0 YvrJ protein family FAM76 PF16046.5 AET40356.1 - 0.75 9.1 23.2 1 8.6 23.2 1.2 1 0 0 1 1 1 0 FAM76 protein Mod_r PF07200.13 AET40356.1 - 1.6 8.8 20.2 0.089 12.9 8.6 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Herpes_UL6 PF01763.16 AET40356.1 - 1.6 7.1 19.7 0.024 13.2 10.2 1.9 1 1 1 2 2 2 0 Herpesvirus UL6 like DUF812 PF05667.11 AET40356.1 - 2.1 7.1 26.8 2.7 6.8 26.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) CP12 PF02672.15 AET40356.1 - 2.4 9.0 11.4 8.2 7.3 2.4 2.7 2 1 0 2 2 2 0 CP12 domain Leu_zip PF15294.6 AET40356.1 - 2.8 7.4 27.6 0.049 13.2 13.1 2.1 1 1 1 2 2 2 0 Leucine zipper NPV_P10 PF05531.12 AET40356.1 - 3.3 8.2 11.6 0.23 11.9 4.5 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein HemX PF04375.14 AET40356.1 - 3.7 6.7 17.8 0.23 10.7 7.1 2.1 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF4094 PF13334.6 AET40356.1 - 4.2 7.9 15.2 1.7 9.1 3.8 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4094) TMPIT PF07851.13 AET40356.1 - 4.2 6.5 17.5 0.81 8.9 7.4 2.1 2 0 0 2 2 2 0 TMPIT-like protein SPT16 PF08644.11 AET40356.1 - 4.8 7.3 21.4 1.4 9.1 6.9 2.5 2 1 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) Cast PF10174.9 AET40356.1 - 5.8 5.0 29.3 1.5e+02 0.4 28.9 2.0 1 1 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone FlaC_arch PF05377.11 AET40356.1 - 6.8 7.2 13.5 0.85 10.1 1.3 3.7 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Gly_acyl_tr_N PF06021.11 AET40356.1 - 9.1 6.3 16.6 0.18 11.9 7.1 2.3 1 1 1 2 2 2 0 Aralkyl acyl-CoA:amino acid N-acyltransferase Macoilin PF09726.9 AET40356.1 - 9.8 4.6 20.9 12 4.3 20.9 1.0 1 0 0 1 1 1 0 Macoilin family ArsA_ATPase PF02374.15 AET40357.1 - 2.7e-115 384.7 0.2 3.2e-115 384.5 0.2 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 AET40357.1 - 4.3e-11 43.0 0.6 2.4e-10 40.6 0.0 2.3 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 AET40357.1 - 4.9e-08 33.1 0.0 1.7e-07 31.3 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 AET40357.1 - 0.00069 19.1 0.6 0.0067 15.9 0.3 2.3 2 1 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase SRP54 PF00448.22 AET40357.1 - 0.0015 18.2 0.0 0.45 10.1 0.0 2.4 2 1 0 2 2 2 2 SRP54-type protein, GTPase domain Fer4_NifH PF00142.18 AET40357.1 - 0.0018 17.8 0.0 0.0038 16.7 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_25 PF13481.6 AET40357.1 - 0.035 13.7 0.0 0.13 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF5344 PF17279.2 AET40357.1 - 0.08 13.5 0.1 0.3 11.7 0.1 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5344) AAA_24 PF13479.6 AET40357.1 - 0.091 12.5 0.1 0.78 9.4 0.1 2.3 1 1 0 1 1 1 0 AAA domain ATG16 PF08614.11 AET40358.1 - 1.4e-10 41.8 12.1 3.1e-10 40.6 7.8 2.1 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Fez1 PF06818.15 AET40358.1 - 0.00039 20.9 2.0 0.00056 20.4 2.0 1.2 1 0 0 1 1 1 1 Fez1 GAS PF13851.6 AET40358.1 - 0.0032 16.8 4.4 0.0054 16.1 4.4 1.4 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding HIP1_clath_bdg PF16515.5 AET40358.1 - 0.0048 17.5 1.7 0.0095 16.5 0.6 1.9 1 1 1 2 2 2 1 Clathrin-binding domain of Huntingtin-interacting protein 1 TMF_TATA_bd PF12325.8 AET40358.1 - 0.0055 16.9 1.4 0.011 16.0 1.4 1.5 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding MetOD2 PF18548.1 AET40358.1 - 0.012 15.7 1.6 0.022 14.9 1.6 1.4 1 0 0 1 1 1 0 Metanogen output domain 2 KLRAQ PF10205.9 AET40358.1 - 0.015 15.5 1.5 0.027 14.7 1.5 1.5 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Macoilin PF09726.9 AET40358.1 - 0.027 13.1 1.7 0.03 12.9 1.7 1.0 1 0 0 1 1 1 0 Macoilin family UPF0767 PF15990.5 AET40358.1 - 0.31 11.2 1.4 1.9 8.7 1.0 2.2 2 1 0 2 2 2 0 UPF0767 family Bap31_Bap29_C PF18035.1 AET40358.1 - 0.86 9.7 10.6 43 4.2 7.6 3.4 2 1 1 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain Pkinase PF00069.25 AET40360.1 - 3.8e-69 233.0 0.0 4.9e-69 232.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40360.1 - 8e-35 120.4 0.0 1e-34 120.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 AET40360.1 - 6.7e-18 64.8 0.4 1.6e-17 63.6 0.4 1.7 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 AET40360.1 - 7.3e-07 29.4 0.0 2.1e-06 28.0 0.0 1.7 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Pkinase_fungal PF17667.1 AET40360.1 - 1.9e-05 23.6 0.0 2.6e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 AET40360.1 - 0.00035 20.0 0.1 0.00056 19.3 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 AET40360.1 - 0.0094 15.5 0.8 0.02 14.4 0.8 1.5 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL Pyr_excise PF03013.14 AET40360.1 - 0.088 12.8 0.1 0.19 11.7 0.1 1.5 1 0 0 1 1 1 0 Pyrimidine dimer DNA glycosylase DNA_pol_B PF00136.21 AET40361.1 - 5.5e-145 483.6 0.2 7.2e-145 483.2 0.2 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 AET40361.1 - 1.2e-83 281.1 0.0 2.2e-83 280.2 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 AET40361.1 - 4.8e-18 65.4 4.7 9.7e-18 64.4 4.7 1.5 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 AET40361.1 - 0.0001 21.3 0.3 0.0016 17.4 0.0 2.3 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral DNA_pol_B_exo2 PF10108.9 AET40361.1 - 0.0089 15.7 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 AET40361.1 - 0.0089 16.0 0.2 0.05 13.6 0.2 2.1 1 1 0 1 1 1 1 RNase_H superfamily DnaJ PF00226.31 AET40362.1 - 1.4e-24 85.9 3.2 2.3e-24 85.3 3.2 1.3 1 0 0 1 1 1 1 DnaJ domain PhoLip_ATPase_C PF16212.5 AET40363.1 - 6.6e-66 222.6 27.5 6.6e-66 222.6 27.5 2.4 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 AET40363.1 - 3.1e-22 78.0 3.5 3.1e-22 78.0 3.5 2.7 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 AET40363.1 - 6.2e-13 48.6 0.0 3e-12 46.4 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 AET40363.1 - 1e-11 44.7 0.0 4e-11 42.8 0.0 2.0 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 AET40363.1 - 3.1e-11 44.0 0.2 0.001 19.4 0.0 3.5 2 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AET40363.1 - 0.0062 16.3 0.5 0.0062 16.3 0.5 3.0 2 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase UDPGP PF01704.18 AET40364.1 - 4.9e-53 180.2 0.0 6.6e-53 179.8 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 AET40364.1 - 0.012 16.0 0.0 0.03 14.7 0.0 1.6 2 0 0 2 2 2 0 MobA-like NTP transferase domain Catalase-rel PF06628.12 AET40364.1 - 0.057 13.6 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 Catalase-related immune-responsive Vezatin PF12632.7 AET40365.1 - 2.2e-07 30.6 8.3 1.2e-06 28.2 8.3 2.1 1 1 0 1 1 1 1 Mysoin-binding motif of peroxisomes LisH PF08513.11 AET40366.1 - 6.5e-08 32.3 0.7 1.1e-07 31.6 0.7 1.4 1 0 0 1 1 1 1 LisH LNS2 PF08235.13 AET40367.1 - 2.8e-96 321.4 0.0 4.4e-96 320.7 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 AET40367.1 - 2.9e-42 142.8 0.0 6.9e-42 141.6 0.0 1.7 1 0 0 1 1 1 1 lipin, N-terminal conserved region Acid_phosphat_B PF03767.14 AET40367.1 - 0.0071 16.0 0.3 0.027 14.0 0.0 2.0 3 0 0 3 3 3 1 HAD superfamily, subfamily IIIB (Acid phosphatase) DUF2608 PF11019.8 AET40367.1 - 0.037 13.5 0.0 0.069 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) Hydrolase_6 PF13344.6 AET40367.1 - 0.058 13.5 0.0 0.19 11.9 0.0 1.9 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Mito_carr PF00153.27 AET40368.1 - 2.9e-63 209.8 2.4 1.4e-22 79.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 AET40368.1 - 0.1 11.7 2.2 2.4 7.2 0.2 2.7 2 2 0 2 2 2 0 Gammaproteobacterial serine protease Peptidase_M22 PF00814.25 AET40369.1 - 4.4e-68 229.9 0.0 5.2e-68 229.7 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Hs1pro-1_N PF07231.12 AET40369.1 - 0.025 14.4 0.0 0.038 13.7 0.0 1.2 1 0 0 1 1 1 0 Hs1pro-1 N-terminus BcrAD_BadFG PF01869.20 AET40369.1 - 0.1 12.1 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family DUF2526 PF10735.9 AET40369.1 - 0.17 12.1 0.1 25 5.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2526) Nse4_C PF08743.10 AET40370.1 - 1.7e-27 95.5 0.7 3.1e-27 94.7 0.0 1.8 2 0 0 2 2 2 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 AET40370.1 - 8.4e-15 54.6 0.8 1.7e-14 53.7 0.8 1.5 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE WD40 PF00400.32 AET40371.1 - 8.4e-24 83.4 6.4 9.2e-07 29.5 0.3 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET40371.1 - 2.2e-09 37.5 1.4 1.1 9.6 0.2 5.1 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AET40371.1 - 3.5e-07 29.3 1.1 0.0023 16.6 0.1 2.9 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 AET40371.1 - 5.4e-06 25.4 1.4 0.43 9.2 0.0 4.3 1 1 3 5 5 5 3 Nup133 N terminal like PALB2_WD40 PF16756.5 AET40371.1 - 0.00015 20.8 0.5 0.0016 17.4 0.0 2.7 2 1 1 3 3 3 1 Partner and localizer of BRCA2 WD40 domain AlaDh_PNT_N PF05222.15 AET40372.1 - 2.9e-31 108.6 0.0 4.5e-31 108.0 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 AET40372.1 - 0.0061 15.9 0.1 0.017 14.4 0.0 1.8 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain PS_pyruv_trans PF04230.13 AET40372.1 - 0.024 14.6 0.0 0.085 12.8 0.0 1.7 2 0 0 2 2 2 0 Polysaccharide pyruvyl transferase TPR_1 PF00515.28 AET40373.1 - 6e-42 139.8 9.2 8.6e-06 25.4 0.0 10.3 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_2 PF07719.17 AET40373.1 - 4.3e-36 120.1 6.6 0.00022 21.1 0.0 10.2 10 0 0 10 10 10 7 Tetratricopeptide repeat ANAPC3 PF12895.7 AET40373.1 - 4e-31 107.1 16.3 4.5e-25 87.7 0.1 5.4 5 2 1 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 AET40373.1 - 1.2e-26 90.7 9.3 4.5e-05 23.3 0.1 10.0 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_12 PF13424.6 AET40373.1 - 3.3e-25 88.2 4.3 2.1e-07 31.2 0.0 8.9 6 2 1 7 7 7 6 Tetratricopeptide repeat TPR_19 PF14559.6 AET40373.1 - 3.8e-20 72.1 0.8 0.0031 18.0 0.0 7.3 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 AET40373.1 - 4e-19 67.6 3.8 0.0051 17.1 0.0 9.0 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 AET40373.1 - 3.1e-15 55.5 0.9 0.07 12.8 0.0 7.2 5 2 2 7 7 7 4 TPR repeat TPR_14 PF13428.6 AET40373.1 - 3.2e-15 55.5 0.0 0.27 12.2 0.0 8.2 5 2 3 8 8 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 AET40373.1 - 1.6e-13 51.1 0.3 0.024 15.3 0.0 6.4 4 2 3 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 AET40373.1 - 1.7e-13 49.5 4.6 0.0038 17.1 0.0 7.6 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_10 PF13374.6 AET40373.1 - 2.2e-13 49.6 2.0 0.023 14.5 0.0 7.5 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 AET40373.1 - 1.6e-11 44.1 9.4 1.4 9.7 0.1 8.7 10 0 0 10 10 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 AET40373.1 - 3.9e-07 30.1 0.5 0.13 12.5 0.0 5.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_15 PF13429.6 AET40373.1 - 2.3e-06 27.1 0.2 3.2 6.9 0.0 5.2 2 2 3 6 6 6 1 Tetratricopeptide repeat SRP_TPR_like PF17004.5 AET40373.1 - 2.3e-05 24.4 4.1 0.11 12.5 0.1 4.4 3 1 1 4 4 4 2 Putative TPR-like repeat TPR_3 PF07720.12 AET40373.1 - 6.4e-05 22.8 3.2 0.29 11.2 0.0 4.4 6 0 0 6 6 4 2 Tetratricopeptide repeat ChAPs PF09295.10 AET40373.1 - 0.00026 20.1 0.6 0.084 11.9 0.1 3.6 3 1 0 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_MalT PF17874.1 AET40373.1 - 0.00045 19.7 2.5 2.4 7.4 0.0 3.9 5 0 0 5 5 5 2 MalT-like TPR region Fis1_TPR_C PF14853.6 AET40373.1 - 0.00058 19.9 7.0 6.4 6.9 0.1 5.6 5 0 0 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.6 AET40373.1 - 0.01 16.1 0.7 10 6.5 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat SNAP PF14938.6 AET40373.1 - 0.033 13.6 3.4 12 5.2 0.1 3.9 3 2 0 3 3 3 0 Soluble NSF attachment protein, SNAP TPR_21 PF09976.9 AET40373.1 - 0.97 9.1 3.8 8.4 6.0 0.0 3.7 3 2 1 4 4 4 0 Tetratricopeptide repeat-like domain ADK PF00406.22 AET40374.1 - 4.7e-45 153.4 0.0 6.4e-45 152.9 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 AET40374.1 - 2.3e-36 125.2 0.0 3.3e-36 124.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AET40374.1 - 2.6e-09 37.7 0.0 4.1e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AET40374.1 - 1.6e-06 28.3 0.0 3.3e-06 27.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 AET40374.1 - 0.00016 21.4 0.2 0.15 11.7 0.0 2.2 1 1 1 2 2 2 2 Thymidylate kinase Zeta_toxin PF06414.12 AET40374.1 - 0.0064 15.8 0.0 0.0092 15.3 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin adh_short PF00106.25 AET40375.1 - 2.1e-46 157.9 0.2 2.7e-46 157.5 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AET40375.1 - 7.8e-31 107.4 0.1 8.8e-31 107.3 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AET40375.1 - 2.3e-10 40.7 0.1 3.3e-10 40.2 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AET40375.1 - 0.0012 18.4 0.1 0.0084 15.6 0.1 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 AET40375.1 - 0.011 15.6 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding TrkA_N PF02254.18 AET40375.1 - 0.033 14.4 0.1 0.068 13.4 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain Polysacc_synt_2 PF02719.15 AET40375.1 - 0.15 11.1 0.1 0.22 10.6 0.1 1.5 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Pan3_PK PF18101.1 AET40376.1 - 9e-54 181.2 0.4 1.3e-53 180.6 0.4 1.3 1 0 0 1 1 1 1 Pan3 Pseudokinase domain HIGH_NTase1 PF05636.11 AET40376.1 - 0.064 12.5 0.1 0.098 11.8 0.1 1.2 1 0 0 1 1 1 0 HIGH Nucleotidyl Transferase Peptidase_S10 PF00450.22 AET40377.1 - 1.7e-125 419.7 0.3 2.2e-125 419.3 0.3 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.11 AET40377.1 - 3.8e-11 43.6 1.0 1.5e-10 41.6 1.6 1.7 2 0 0 2 2 2 1 Carboxypeptidase Y pro-peptide Baculo_DNA_bind PF04786.12 AET40377.1 - 0.14 11.5 0.1 0.23 10.8 0.1 1.3 1 0 0 1 1 1 0 ssDNA binding protein Cbl_N3 PF02762.14 AET40378.1 - 0.015 15.1 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain DUF3591 PF12157.8 AET40379.1 - 1.5e-176 587.4 1.4 1.5e-176 587.4 1.4 1.7 3 0 0 3 3 3 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.6 AET40379.1 - 8.4e-08 31.9 0.8 1.9e-07 30.8 0.8 1.6 1 0 0 1 1 1 1 Zinc knuckle SAP30_Sin3_bdg PF13867.6 AET40379.1 - 0.075 13.4 0.1 0.23 11.8 0.1 1.9 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 Rtt102p PF09510.10 AET40380.1 - 6.3e-24 84.7 3.0 1.7e-22 80.1 3.0 2.4 1 1 0 1 1 1 1 Rtt102p-like transcription regulator protein RNase_T PF00929.24 AET40381.1 - 2.3e-07 31.5 0.0 5e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 Exonuclease Methyltransf_22 PF13383.6 AET40381.1 - 0.083 12.4 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain DLIC PF05783.11 AET40382.1 - 1.1e-05 24.5 0.0 2.3e-05 23.4 0.0 1.4 1 1 0 1 1 1 1 Dynein light intermediate chain (DLIC) GATase_6 PF13522.6 AET40383.1 - 9.7e-14 51.7 0.0 2.1e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 AET40383.1 - 1.7e-10 40.8 0.0 3e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 AET40383.1 - 1.6e-08 34.2 0.0 2.6e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 AET40383.1 - 0.0023 16.9 0.0 0.0036 16.3 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Pribosyl_synth PF14572.6 AET40383.1 - 0.11 12.6 0.2 0.26 11.3 0.2 1.6 1 1 0 1 1 1 0 Phosphoribosyl synthetase-associated domain ABC_membrane PF00664.23 AET40384.1 - 3.9e-44 151.4 17.8 5e-44 151.0 17.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 AET40384.1 - 5e-34 117.7 0.0 9.5e-34 116.9 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 AET40384.1 - 1.4e-09 37.7 0.2 1.4e-05 24.6 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 AET40384.1 - 0.00027 20.6 0.2 0.00065 19.4 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 AET40384.1 - 0.00061 20.2 0.0 0.0012 19.2 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 AET40384.1 - 0.00098 18.9 0.0 0.0035 17.1 0.0 1.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AET40384.1 - 0.0022 18.3 0.0 0.012 15.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.6 AET40384.1 - 0.0022 17.9 0.4 0.016 15.0 0.0 2.4 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 AET40384.1 - 0.0085 16.6 1.1 0.024 15.1 0.2 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AET40384.1 - 0.021 14.5 0.0 0.051 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AET40384.1 - 0.091 12.3 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 AET40384.1 - 0.17 11.1 0.0 0.38 10.0 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin SbcCD_C PF13558.6 AET40384.1 - 0.31 11.3 1.2 1.3 9.3 0.2 2.5 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Proteasome PF00227.26 AET40385.1 - 1e-46 158.9 0.1 1.2e-46 158.6 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AET40385.1 - 7e-12 44.8 0.1 1.3e-11 43.9 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF3336 PF11815.8 AET40386.1 - 6.3e-26 90.7 0.0 1.2e-25 89.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 AET40386.1 - 4.8e-08 33.4 0.0 9e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase DUF2535 PF10751.9 AET40386.1 - 0.0066 16.9 0.3 0.024 15.1 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2535) ELP6 PF09807.9 AET40387.1 - 0.0058 16.1 0.0 0.0076 15.7 0.0 1.3 1 0 0 1 1 1 1 Elongation complex protein 6 SURF4 PF02077.15 AET40388.1 - 6.6e-94 314.4 12.2 7.5e-94 314.2 12.2 1.0 1 0 0 1 1 1 1 SURF4 family IPP-2 PF04979.14 AET40389.1 - 6.9e-22 78.6 13.0 6.9e-22 78.6 13.0 2.0 2 0 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) Glyco_hydro_17 PF00332.18 AET40390.1 - 4e-83 279.6 0.2 4.5e-83 279.4 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 eIF-3c_N PF05470.12 AET40391.1 - 1.5e-157 525.5 1.7 1.8e-121 406.4 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 AET40391.1 - 6.7e-09 36.2 2.3 2.4e-08 34.4 0.4 3.0 4 1 0 4 4 4 1 PCI domain Ribosomal_L27_C PF18471.1 AET40391.1 - 0.0065 15.9 1.1 0.017 14.5 1.1 1.7 1 0 0 1 1 1 1 Ribosomal L27 protein C-terminal domain Vma12 PF11712.8 AET40392.1 - 0.025 14.7 1.1 0.065 13.3 1.1 1.7 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase HMG_box PF00505.19 AET40392.1 - 0.16 12.4 8.3 2.2 8.7 0.0 3.1 3 0 0 3 3 3 0 HMG (high mobility group) box DUF4825 PF16107.5 AET40392.1 - 1.3 9.2 4.5 5.8 7.1 4.5 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4825) ABC_membrane PF00664.23 AET40393.1 - 3.3e-64 217.2 46.5 4.5e-40 138.0 18.9 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 AET40393.1 - 7.4e-50 169.0 0.4 4e-29 101.9 0.1 4.2 2 2 0 2 2 2 2 ABC transporter SMC_N PF02463.19 AET40393.1 - 1e-08 34.9 0.0 0.015 14.8 0.2 4.2 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 AET40393.1 - 9.3e-08 32.2 2.1 0.00071 19.5 0.3 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 AET40393.1 - 1.5e-07 31.0 1.4 0.0037 17.0 0.3 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 AET40393.1 - 3.5e-06 27.0 0.4 0.71 9.6 0.0 4.0 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.20 AET40393.1 - 3.8e-05 22.9 0.4 0.033 13.2 0.0 2.6 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_18 PF13238.6 AET40393.1 - 6.8e-05 23.4 3.9 0.49 10.9 0.2 3.7 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 AET40393.1 - 7.6e-05 22.8 2.1 0.049 13.7 0.2 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 AET40393.1 - 0.00019 21.9 0.4 0.054 13.9 0.0 3.2 3 0 0 3 3 3 1 AAA ATPase domain AAA_15 PF13175.6 AET40393.1 - 0.00022 21.1 0.1 0.15 11.7 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 AET40393.1 - 0.00045 20.8 14.1 0.13 12.7 0.1 3.3 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.6 AET40393.1 - 0.00063 20.0 2.0 1.1 9.6 0.1 3.5 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.6 AET40393.1 - 0.0015 18.8 1.3 0.038 14.2 0.1 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AET40393.1 - 0.0024 17.6 6.5 0.22 11.2 0.0 3.5 3 0 0 3 3 3 1 AAA domain ATP-synt_ab PF00006.25 AET40393.1 - 0.0053 16.4 0.0 2.1 8.0 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain Dynamin_N PF00350.23 AET40393.1 - 0.006 16.6 3.0 1.5 8.8 0.0 3.2 3 0 0 3 3 3 1 Dynamin family FtsK_SpoIIIE PF01580.18 AET40393.1 - 0.008 15.6 0.2 5 6.4 0.1 2.6 2 0 0 2 2 2 1 FtsK/SpoIIIE family TsaE PF02367.17 AET40393.1 - 0.0088 16.0 0.5 2.6 8.1 0.1 3.2 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 AET40393.1 - 0.0098 15.6 5.7 0.49 10.1 0.0 3.3 4 0 0 4 4 3 1 IstB-like ATP binding protein ATP_bind_1 PF03029.17 AET40393.1 - 0.035 13.9 1.1 3.2 7.5 0.1 3.1 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 AET40393.1 - 0.038 13.6 0.6 3.6 7.1 0.0 3.2 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 AET40393.1 - 0.049 14.0 0.2 8.2 6.9 0.0 3.2 2 0 0 2 2 2 0 RNA helicase AAA_7 PF12775.7 AET40393.1 - 0.059 12.9 0.3 10 5.6 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region NTPase_1 PF03266.15 AET40393.1 - 0.079 12.9 2.3 6.5 6.6 0.3 2.5 2 0 0 2 2 2 0 NTPase AAA_27 PF13514.6 AET40393.1 - 0.079 12.5 0.1 2.4 7.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 AET40393.1 - 0.085 12.1 0.3 8 5.7 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin MeaB PF03308.16 AET40393.1 - 0.14 11.1 0.7 0.55 9.2 0.1 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB APS_kinase PF01583.20 AET40393.1 - 0.17 11.7 0.8 2.7 7.8 0.1 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase cobW PF02492.19 AET40393.1 - 0.18 11.4 2.9 0.45 10.1 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 AET40393.1 - 0.31 11.5 1.5 6.2 7.2 0.1 3.3 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) dNK PF01712.19 AET40393.1 - 0.38 10.6 2.9 5.8 6.7 0.3 2.5 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_19 PF13245.6 AET40393.1 - 7.2 6.9 6.7 4.6 7.6 0.1 3.1 3 0 0 3 3 3 0 AAA domain CBS PF00571.28 AET40394.1 - 3.8e-21 75.3 4.7 5e-05 23.7 0.1 5.7 6 0 0 6 6 6 4 CBS domain Fungal_trans PF04082.18 AET40395.1 - 2.1e-17 63.0 0.4 6.7e-17 61.4 0.4 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Nucleocap_ssRNA PF11128.8 AET40395.1 - 0.09 12.5 0.0 0.29 10.8 0.0 1.9 2 0 0 2 2 2 0 Plant viral coat protein nucleocapsid Importin_rep_6 PF18829.1 AET40396.1 - 7.3e-51 170.9 1.5 7.3e-51 170.9 1.5 4.0 4 0 0 4 4 4 1 Importin repeat 6 Importin_rep_4 PF18808.1 AET40396.1 - 1.1e-31 108.9 1.4 1.1e-31 108.9 1.4 3.7 4 1 1 5 5 4 1 Importin repeat Importin_rep_5 PF18816.1 AET40396.1 - 1.4e-23 82.9 1.2 1.4e-23 82.9 1.2 2.6 3 0 0 3 3 3 1 Importin repeat HEAT_EZ PF13513.6 AET40396.1 - 5.1e-21 74.8 1.6 7.7e-10 39.1 0.0 7.3 6 1 1 7 7 6 3 HEAT-like repeat HEAT_2 PF13646.6 AET40396.1 - 1.6e-14 54.0 0.0 1.2e-05 25.6 0.0 6.7 4 2 3 7 7 7 3 HEAT repeats HEAT PF02985.22 AET40396.1 - 7.7e-12 44.4 4.8 0.014 15.6 0.0 8.9 10 0 0 10 10 10 2 HEAT repeat Adaptin_N PF01602.20 AET40396.1 - 9.7e-08 31.0 3.3 0.71 8.3 0.0 4.7 3 1 1 4 4 4 4 Adaptin N terminal region Arm PF00514.23 AET40396.1 - 1.4e-06 28.1 0.1 5.1 7.3 0.1 5.6 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat RIX1 PF08167.12 AET40396.1 - 4.7e-06 26.5 1.6 0.00028 20.7 0.5 3.7 3 1 1 4 4 4 1 rRNA processing/ribosome biogenesis DUF3385 PF11865.8 AET40396.1 - 5.7e-06 26.3 2.9 0.006 16.5 0.7 5.4 4 3 1 5 5 5 1 Domain of unknown function (DUF3385) IFRD PF05004.13 AET40396.1 - 1.2e-05 24.6 6.7 0.013 14.6 0.9 3.9 4 0 0 4 4 4 2 Interferon-related developmental regulator (IFRD) Vac14_Fab1_bd PF12755.7 AET40396.1 - 1.5e-05 25.5 0.1 0.16 12.6 0.0 5.5 5 1 2 7 7 6 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 AET40396.1 - 1.7e-05 24.9 0.9 0.85 9.6 0.0 5.5 4 3 2 6 6 6 1 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 AET40396.1 - 0.00011 21.5 16.2 0.00075 18.7 4.4 3.8 4 0 0 4 4 4 2 RNAPII transcription regulator C-terminal CLASP_N PF12348.8 AET40396.1 - 0.00016 21.3 1.0 0.027 14.0 0.8 4.4 3 2 2 5 5 5 1 CLASP N terminal RTP1_C1 PF10363.9 AET40396.1 - 0.014 15.6 0.6 8.5 6.6 0.1 4.2 3 1 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 DNA_alkylation PF08713.11 AET40396.1 - 0.031 14.0 0.0 0.16 11.7 0.0 2.3 2 1 0 2 2 2 0 DNA alkylation repair enzyme G-patch PF01585.23 AET40397.1 - 4.5e-10 39.3 0.1 9.6e-10 38.2 0.1 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 AET40397.1 - 0.0013 18.8 0.0 0.0013 18.8 0.0 3.8 2 1 0 2 2 2 1 G-patch domain SLC12 PF03522.15 AET40397.1 - 1.4 7.9 22.4 1.8 7.5 22.4 1.3 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 AET40397.1 - 1.6 6.9 28.0 2.1 6.6 28.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.16 AET40397.1 - 3.6 7.6 11.8 5.3 7.0 11.8 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Glyco_hydro_72 PF03198.14 AET40398.1 - 9.8e-144 478.4 4.9 1.3e-143 478.0 4.9 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 AET40398.1 - 4.3e-26 91.4 5.2 1.4e-25 89.8 5.2 1.9 1 0 0 1 1 1 1 X8 domain Cellulase PF00150.18 AET40398.1 - 0.00036 20.0 0.0 0.0028 17.1 0.0 2.0 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 AET40398.1 - 0.0058 15.8 0.1 0.015 14.4 0.1 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain DUF1180 PF06679.12 AET40398.1 - 0.29 11.5 3.1 8.1 6.8 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Glyco_hydro_72 PF03198.14 AET40399.1 - 2.7e-140 467.1 6.9 3.6e-140 466.7 6.9 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 AET40399.1 - 2e-23 82.9 3.6 2e-23 82.9 3.6 2.4 2 0 0 2 2 2 1 X8 domain Cellulase PF00150.18 AET40399.1 - 0.0017 17.9 0.0 0.017 14.6 0.0 2.4 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_17 PF00332.18 AET40400.1 - 1.9e-08 34.3 0.1 5.1e-08 32.9 0.1 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 PhageMin_Tail PF10145.9 AET40400.1 - 0.083 12.7 0.7 0.17 11.7 0.6 1.5 1 1 0 1 1 1 0 Phage-related minor tail protein SPX PF03105.19 AET40400.1 - 4.4 7.1 11.6 5.9 6.7 11.6 1.1 1 0 0 1 1 1 0 SPX domain SOG2 PF10428.9 AET40400.1 - 5.3 6.1 7.2 7 5.7 7.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein MA3 PF02847.17 AET40401.1 - 2.6e-22 78.9 0.7 6.3e-21 74.5 0.1 2.7 2 0 0 2 2 2 1 MA3 domain CTP_transf_like PF01467.26 AET40402.1 - 2.1e-09 37.7 0.0 3.3e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like USP7_C2 PF14533.6 AET40403.1 - 1.9e-57 194.3 5.3 6.6e-56 189.3 2.1 3.3 3 0 0 3 3 3 1 Ubiquitin-specific protease C-terminal UCH PF00443.29 AET40403.1 - 2.1e-46 158.5 1.5 4e-46 157.6 1.5 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.8 AET40403.1 - 6.2e-34 117.4 0.1 6.2e-34 117.4 0.1 3.0 3 0 0 3 3 3 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH_1 PF13423.6 AET40403.1 - 2.4e-23 83.2 0.0 2e-22 80.2 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 AET40403.1 - 1.5e-05 25.1 0.0 7.2e-05 22.9 0.0 2.3 1 0 0 1 1 1 1 MATH domain ADH_N_2 PF16884.5 AET40404.1 - 1.5e-18 66.7 0.0 2.4e-18 66.0 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 AET40404.1 - 1.1e-17 64.2 0.1 1.8e-17 63.5 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AET40404.1 - 0.0042 18.1 0.0 0.014 16.5 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase LAB_N PF07578.11 AET40404.1 - 0.1 12.7 0.9 0.28 11.3 0.2 2.0 2 0 0 2 2 2 0 Lipid A Biosynthesis N-terminal domain Fungal_trans_2 PF11951.8 AET40405.1 - 8.1e-08 31.5 0.4 1.3e-07 30.8 0.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET40405.1 - 1.4e-07 31.5 7.9 3e-07 30.4 7.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Transp_cyt_pur PF02133.15 AET40406.1 - 5.8e-73 246.2 29.5 7.5e-73 245.8 29.5 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin FH2 PF02181.23 AET40408.1 - 2.5e-68 230.9 8.5 2.5e-68 230.9 8.5 1.8 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 AET40408.1 - 3.1e-08 33.5 3.5 5e-07 29.5 2.0 2.8 2 0 0 2 2 2 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 AET40408.1 - 9.6e-08 31.8 0.5 9.6e-08 31.8 0.5 2.3 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain ssDNA_DBD PF18333.1 AET40408.1 - 0.017 15.2 0.1 0.12 12.5 0.1 2.5 1 0 0 1 1 1 0 Non-canonical single-stranded DNA-binding domain MqsR_toxin PF15723.5 AET40408.1 - 0.11 12.9 0.1 0.39 11.1 0.1 2.0 1 0 0 1 1 1 0 Motility quorum-sensing regulator, toxin of MqsA Hexokinase_2 PF03727.16 AET40409.1 - 1.4e-78 263.6 0.0 1.8e-78 263.3 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 AET40409.1 - 3.5e-68 229.4 0.0 4.5e-68 229.1 0.0 1.1 1 0 0 1 1 1 1 Hexokinase FGGY_N PF00370.21 AET40409.1 - 0.023 14.2 0.0 0.036 13.6 0.0 1.3 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain CSN8_PSD8_EIF3K PF10075.9 AET40410.1 - 7.4e-19 68.2 0.7 1.2e-18 67.5 0.7 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 AET40410.1 - 5.1e-05 22.8 0.4 7.2e-05 22.3 0.4 1.2 1 0 0 1 1 1 1 SAC3/GANP family Ppx-GppA PF02541.16 AET40411.1 - 9.6e-64 215.5 0.0 1.3e-63 215.1 0.0 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family RRM_3 PF08777.11 AET40411.1 - 0.1 12.7 0.0 1.6 8.8 0.0 2.6 2 0 0 2 2 2 0 RNA binding motif TSCPD PF12637.7 AET40411.1 - 0.15 12.3 0.1 1.8 8.9 0.0 2.5 2 0 0 2 2 2 0 TSCPD domain Sec63 PF02889.16 AET40412.1 - 4.2e-29 101.5 2.4 1.2e-28 100.0 1.1 2.4 2 0 0 2 2 2 1 Sec63 Brl domain DEAD PF00270.29 AET40412.1 - 8.5e-24 84.3 0.2 7.8e-23 81.1 0.0 2.6 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET40412.1 - 4.6e-13 49.5 0.1 6.3e-12 45.8 0.1 2.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET40412.1 - 3.8e-10 40.0 1.2 5.8e-10 39.4 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 AET40412.1 - 0.0046 17.2 0.0 0.021 15.1 0.0 2.1 1 0 0 1 1 1 1 AAA domain Alba PF01918.21 AET40412.1 - 0.02 14.7 0.0 0.22 11.4 0.0 2.7 2 0 0 2 2 2 0 Alba T2SSE PF00437.20 AET40412.1 - 0.021 13.9 0.0 0.057 12.5 0.0 1.8 1 0 0 1 1 1 0 Type II/IV secretion system protein TniB PF05621.11 AET40412.1 - 0.035 13.5 0.5 0.97 8.8 0.0 2.7 3 0 0 3 3 3 0 Bacterial TniB protein AAA_19 PF13245.6 AET40412.1 - 0.12 12.7 0.0 0.37 11.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 AET40412.1 - 0.14 11.7 0.0 0.14 11.7 0.0 2.5 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain DUF2420 PF10336.9 AET40413.1 - 1.9e-34 117.9 1.9 3.1e-34 117.3 1.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Adap_comp_sub PF00928.21 AET40415.1 - 6.4e-13 48.7 0.3 1.3e-12 47.7 0.3 1.5 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 AET40415.1 - 6.2e-06 26.2 0.8 1.2e-05 25.2 0.8 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Proteasome PF00227.26 AET40416.1 - 4.1e-25 88.4 0.1 5e-25 88.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit PDEase_II PF02112.15 AET40417.1 - 8.9e-62 209.1 0.0 1.3e-61 208.6 0.0 1.2 1 0 0 1 1 1 1 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.7 AET40417.1 - 2.1e-06 27.4 0.0 3e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 AET40417.1 - 0.26 11.3 1.7 0.6 10.1 0.4 2.1 2 1 0 2 2 2 0 Metallo-beta-lactamase superfamily S36_mt PF10937.8 AET40418.1 - 5.3e-22 79.6 0.0 7e-22 79.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial Ribonuc_red_sm PF00268.21 AET40419.1 - 2.3e-117 391.4 0.8 2.9e-117 391.1 0.8 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF4744 PF15918.5 AET40419.1 - 0.12 13.2 0.0 0.31 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4744) PRA1 PF03208.19 AET40419.1 - 0.21 11.2 0.1 0.43 10.2 0.0 1.6 2 0 0 2 2 2 0 PRA1 family protein Thi4 PF01946.17 AET40420.1 - 4.7e-104 346.8 0.1 5.7e-104 346.5 0.1 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 AET40420.1 - 3.8e-07 30.0 2.1 7e-07 29.2 1.2 1.7 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 AET40420.1 - 1.5e-06 28.3 0.5 1.4e-05 25.2 0.2 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 AET40420.1 - 1.4e-05 25.2 0.2 0.00013 22.0 0.1 2.4 3 0 0 3 3 3 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 AET40420.1 - 1.5e-05 24.3 1.9 0.00065 18.9 1.1 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 AET40420.1 - 0.00041 19.7 0.1 0.00055 19.3 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 AET40420.1 - 0.00043 19.4 0.5 0.00078 18.6 0.5 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 AET40420.1 - 0.0025 17.1 0.0 0.0049 16.2 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 AET40420.1 - 0.0033 16.8 1.2 0.0053 16.2 1.2 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 AET40420.1 - 0.013 14.2 0.5 0.026 13.3 0.5 1.5 1 0 0 1 1 1 0 HI0933-like protein FAD_binding_3 PF01494.19 AET40420.1 - 0.023 13.9 0.1 0.037 13.3 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.14 AET40420.1 - 0.03 13.2 0.3 0.046 12.6 0.3 1.2 1 0 0 1 1 1 0 Tryptophan halogenase GIDA PF01134.22 AET40420.1 - 0.037 13.1 0.3 0.1 11.6 0.2 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A K_oxygenase PF13434.6 AET40420.1 - 0.088 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Speriolin_C PF15059.6 AET40421.1 - 0.079 13.1 2.2 0.36 10.9 0.7 2.3 1 1 2 3 3 3 0 Speriolin C-terminus TMIE PF16038.5 AET40421.1 - 0.51 10.2 2.0 1.3 8.9 0.6 2.3 2 0 0 2 2 2 0 TMIE protein Bravo_FIGEY PF13882.6 AET40421.1 - 1.7 10.1 6.1 4.4 8.7 1.4 3.1 1 1 1 3 3 3 0 Bravo-like intracellular region LsmAD PF06741.13 AET40422.1 - 1.5e-27 95.9 0.1 1.5e-27 95.9 0.1 2.4 2 1 0 2 2 2 1 LsmAD domain SM-ATX PF14438.6 AET40422.1 - 7.6e-16 58.0 1.0 1.6e-15 57.0 0.1 2.1 2 0 0 2 2 2 1 Ataxin 2 SM domain LSM14 PF12701.7 AET40422.1 - 0.064 13.4 0.1 0.13 12.4 0.1 1.6 1 0 0 1 1 1 0 Scd6-like Sm domain zf-RRN7 PF11781.8 AET40423.1 - 6.1e-10 38.6 1.1 9.8e-10 38.0 1.1 1.3 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 SE PF08491.10 AET40424.1 - 1.8e-113 378.2 0.1 2.3e-113 377.8 0.1 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 AET40424.1 - 5.2e-15 55.6 0.0 1.1e-14 54.5 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 AET40424.1 - 2.7e-07 30.5 0.1 9.8e-06 25.4 0.2 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 AET40424.1 - 0.00012 22.3 0.1 0.00041 20.5 0.1 2.0 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 AET40424.1 - 0.00029 20.3 0.6 0.00079 18.9 0.2 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 AET40424.1 - 0.0004 19.6 0.3 0.00072 18.8 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain Shikimate_DH PF01488.20 AET40424.1 - 0.00096 19.2 0.0 0.0018 18.4 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 AET40424.1 - 0.0011 19.5 1.8 0.0012 19.4 0.2 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 AET40424.1 - 0.0011 18.2 0.0 0.0021 17.3 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 AET40424.1 - 0.0023 17.2 0.1 0.0046 16.2 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 AET40424.1 - 0.0025 17.7 0.2 0.0041 17.0 0.2 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GDI PF00996.18 AET40424.1 - 0.015 13.9 0.1 0.041 12.4 0.0 1.6 2 0 0 2 2 2 0 GDP dissociation inhibitor GIDA PF01134.22 AET40424.1 - 0.021 13.9 0.7 0.047 12.8 0.2 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A HI0933_like PF03486.14 AET40424.1 - 0.023 13.4 0.1 0.035 12.8 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein ApbA PF02558.16 AET40424.1 - 0.037 13.7 0.0 0.094 12.4 0.0 1.7 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.12 AET40424.1 - 0.037 13.1 0.3 0.35 9.9 0.2 2.2 3 0 0 3 3 3 0 Lycopene cyclase protein Trp_halogenase PF04820.14 AET40424.1 - 0.084 11.7 1.6 0.28 10.0 0.4 2.2 3 0 0 3 3 3 0 Tryptophan halogenase UDPG_MGDP_dh_N PF03721.14 AET40424.1 - 0.15 11.6 0.3 0.31 10.6 0.1 1.6 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 AET40424.1 - 0.19 12.0 0.2 0.39 11.0 0.2 1.5 1 0 0 1 1 1 0 TrkA-N domain CBP4 PF07960.11 AET40425.1 - 3.2e-55 185.5 0.8 3.8e-55 185.3 0.8 1.0 1 0 0 1 1 1 1 CBP4 Fez1 PF06818.15 AET40425.1 - 0.0074 16.8 5.3 0.0089 16.5 5.3 1.1 1 0 0 1 1 1 1 Fez1 DUF600 PF04634.12 AET40425.1 - 0.0085 16.2 0.2 0.055 13.5 0.0 2.0 1 1 0 2 2 2 1 Protein of unknown function, DUF600 DUF4574 PF15141.6 AET40425.1 - 0.011 15.6 0.8 0.048 13.6 0.0 2.1 2 1 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 Jnk-SapK_ap_N PF09744.9 AET40425.1 - 8.5 6.6 12.4 1.8e+02 2.3 12.4 2.0 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Clat_adaptor_s PF01217.20 AET40426.1 - 1.2e-54 184.1 0.4 1.6e-54 183.7 0.4 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain AA_permease PF00324.21 AET40427.1 - 7.3e-152 506.3 35.2 9e-152 506.0 35.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AET40427.1 - 1.8e-40 139.1 35.8 2.4e-40 138.7 35.8 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4389 PF14333.6 AET40427.1 - 0.12 12.3 0.2 0.12 12.3 0.2 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4389) SET PF00856.28 AET40428.1 - 1.8e-09 38.2 0.0 6.6e-07 29.9 0.0 2.5 2 0 0 2 2 2 2 SET domain Sugar_tr PF00083.24 AET40429.1 - 1.7e-30 106.3 26.2 2.4e-30 105.8 26.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AET40429.1 - 6.7e-30 104.2 23.4 6.6e-29 100.9 23.7 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily SMK-1 PF04802.15 AET40429.1 - 0.044 13.6 0.0 0.1 12.4 0.0 1.5 1 1 0 1 1 1 0 Component of IIS longevity pathway SMK-1 CbtB PF09489.10 AET40429.1 - 0.42 10.8 0.1 0.42 10.8 0.1 3.2 3 0 0 3 3 3 0 Probable cobalt transporter subunit (CbtB) Ribosomal_L4 PF00573.22 AET40430.1 - 1.3e-43 148.9 0.8 2.2e-43 148.2 0.8 1.4 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 AET40430.1 - 3.2e-31 107.2 4.8 6.7e-31 106.2 0.8 2.6 2 1 1 3 3 3 1 60S ribosomal protein L4 C-terminal domain Methyltransf_25 PF13649.6 AET40431.1 - 8.9e-13 48.8 0.0 1.4e-11 45.0 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 AET40431.1 - 1.4e-11 44.3 1.3 1.7e-11 44.1 0.2 1.7 2 1 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 AET40431.1 - 1.5e-10 41.1 0.0 4.8e-10 39.4 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AET40431.1 - 5.2e-09 36.6 0.0 3.2e-08 34.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AET40431.1 - 1e-07 32.0 0.0 1.7e-07 31.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 AET40431.1 - 9e-07 28.1 0.1 1.2e-06 27.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 AET40431.1 - 8.4e-06 25.3 0.0 1.2e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 AET40431.1 - 2.7e-05 23.8 0.5 5.8e-05 22.7 0.1 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_18 PF12847.7 AET40431.1 - 5.8e-05 23.1 0.1 9.7e-05 22.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AET40431.1 - 0.00015 22.5 0.0 0.0006 20.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_2 PF00891.18 AET40431.1 - 0.00035 19.9 0.0 0.0007 18.9 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_16 PF10294.9 AET40431.1 - 0.00048 19.9 0.1 0.00076 19.3 0.1 1.3 1 0 0 1 1 1 1 Lysine methyltransferase FtsJ PF01728.19 AET40431.1 - 0.0012 19.0 0.0 0.0026 17.9 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.19 AET40431.1 - 0.0058 16.4 0.1 0.008 15.9 0.1 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 AET40431.1 - 0.0069 15.8 0.1 0.012 15.0 0.1 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_32 PF13679.6 AET40431.1 - 0.015 15.3 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PRMT5 PF05185.16 AET40431.1 - 0.054 13.3 0.1 0.13 12.1 0.1 1.6 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Methyltransf_24 PF13578.6 AET40431.1 - 0.073 14.1 0.0 0.14 13.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain DOT1 PF08123.13 AET40431.1 - 0.075 12.5 0.2 0.15 11.6 0.2 1.5 1 1 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_4 PF02390.17 AET40431.1 - 0.12 11.8 0.8 0.21 11.1 0.1 1.7 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_10 PF05971.12 AET40432.1 - 7.9e-43 146.9 0.0 1e-42 146.6 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase Methyltransf_31 PF13847.6 AET40432.1 - 0.00068 19.4 0.1 0.0017 18.2 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AET40432.1 - 0.00074 19.1 0.0 0.002 17.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 AET40432.1 - 0.0011 18.4 0.1 0.002 17.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 AET40432.1 - 0.0067 16.4 0.2 0.029 14.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Sterile PF03015.19 AET40432.1 - 0.028 14.6 0.7 0.41 10.9 0.4 2.3 2 0 0 2 2 2 0 Male sterility protein PCMT PF01135.19 AET40432.1 - 0.041 13.6 0.0 0.064 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 AET40432.1 - 0.048 14.4 0.0 0.097 13.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Sld5 PF05916.11 AET40433.1 - 8.9e-08 32.6 0.1 1.5e-07 31.8 0.1 1.4 1 1 0 1 1 1 1 GINS complex protein PIF1 PF05970.14 AET40433.1 - 0.02 14.1 0.0 0.023 13.9 0.0 1.2 1 1 0 1 1 1 0 PIF1-like helicase DASH_Dad3 PF08656.10 AET40433.1 - 0.084 13.0 0.5 0.42 10.7 0.0 2.3 2 1 0 2 2 2 0 DASH complex subunit Dad3 SLD5_C PF16922.5 AET40433.1 - 0.14 12.4 0.1 0.43 10.8 0.0 1.9 2 0 0 2 2 2 0 DNA replication complex GINS protein SLD5 C-terminus Wap1 PF16997.5 AET40434.1 - 5.4e-117 391.2 17.5 7.3e-117 390.7 17.5 1.2 1 0 0 1 1 1 1 Wap1 domain Flavi_NS5 PF00972.20 AET40434.1 - 0.048 11.8 0.1 0.07 11.3 0.1 1.1 1 0 0 1 1 1 0 Flavivirus RNA-directed RNA polymerase PNP_phzG_C PF10590.9 AET40435.1 - 7.7e-19 67.5 1.2 2.1e-18 66.1 1.2 1.8 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 AET40435.1 - 7.4e-17 61.3 0.0 1.2e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 AET40435.1 - 0.0017 18.9 0.1 0.0047 17.5 0.1 1.7 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 AET40435.1 - 0.01 15.5 0.1 0.56 9.8 0.0 2.3 1 1 1 2 2 2 1 Pyridoxamine 5'-phosphate oxidase like DnaA_N PF11638.8 AET40435.1 - 0.042 13.6 0.1 1.4 8.8 0.0 2.3 2 0 0 2 2 2 0 DnaA N-terminal domain CRCB PF02537.15 AET40436.1 - 2.1e-23 82.4 13.5 1.1e-15 57.6 3.8 2.3 2 0 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) DctQ PF04290.12 AET40436.1 - 0.027 14.4 5.4 0.079 12.9 0.1 3.0 2 1 1 3 3 3 0 Tripartite ATP-independent periplasmic transporters, DctQ component DASH_Dad1 PF08649.10 AET40437.1 - 2.2e-24 85.4 0.6 3.9e-24 84.6 0.6 1.4 1 0 0 1 1 1 1 DASH complex subunit Dad1 Mso1_Sec1_bdg PF14475.6 AET40438.1 - 7.7e-20 70.2 0.1 2e-19 68.9 0.1 1.7 1 0 0 1 1 1 1 Sec1-binding region of Mso1 Hydantoinase_B PF02538.14 AET40439.1 - 2.4e-203 676.2 0.2 3.6e-203 675.6 0.2 1.3 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 AET40439.1 - 3.6e-102 341.6 1.4 4.5e-102 341.2 0.1 1.8 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 AET40439.1 - 1e-58 198.0 0.7 1.1e-56 191.3 0.0 2.6 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Not1 PF04054.15 AET40440.1 - 4.5e-127 424.0 1.8 4.5e-127 424.0 1.8 3.6 3 0 0 3 3 3 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 AET40440.1 - 1.1e-87 293.2 7.6 1.1e-87 293.2 7.6 2.5 3 0 0 3 3 2 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_HEAT_N PF16419.5 AET40440.1 - 2.1e-84 282.8 8.2 2.1e-84 282.8 8.2 3.3 4 0 0 4 4 3 1 CCR4-NOT transcription complex subunit 1 HEAT repeat CNOT1_TTP_bind PF16417.5 AET40440.1 - 5.8e-42 143.0 0.2 5.8e-42 143.0 0.2 4.3 4 0 0 4 4 3 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.7 AET40440.1 - 8.4e-42 142.6 4.8 8.4e-42 142.6 4.8 3.3 2 0 0 2 2 1 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.5 AET40440.1 - 6.2e-16 58.8 0.1 6.2e-16 58.8 0.1 4.6 4 0 0 4 4 3 1 CCR4-NOT transcription complex subunit 1 HEAT repeat DUF2420 PF10336.9 AET40440.1 - 0.00086 19.3 2.1 0.0055 16.7 0.2 3.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2420) TFIIA PF03153.13 AET40440.1 - 0.03 14.3 51.5 0.045 13.8 27.2 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 AET40440.1 - 0.55 10.4 11.4 0.21 11.7 3.7 2.6 2 0 0 2 2 2 0 DDHD domain Gti1_Pac2 PF09729.9 AET40440.1 - 0.86 9.7 10.7 1.9 8.6 2.3 2.4 2 0 0 2 2 2 0 Gti1/Pac2 family YjbH PF06082.11 AET40440.1 - 3 6.6 16.2 0.049 12.4 4.3 2.2 2 0 0 2 2 2 0 Exopolysaccharide biosynthesis protein YbjH DUF1764 PF08576.10 AET40440.1 - 5.9 7.9 13.4 0.26 12.2 7.3 1.9 2 0 0 2 2 1 0 Eukaryotic protein of unknown function (DUF1764) Presenilin PF01080.17 AET40440.1 - 8.8 5.0 17.9 0.035 12.9 6.4 2.3 2 0 0 2 2 2 0 Presenilin CDC50 PF03381.15 AET40441.1 - 4.2e-94 315.2 1.6 5e-94 314.9 1.6 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family UQ_con PF00179.26 AET40442.1 - 6.3e-44 149.0 0.0 7.8e-44 148.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 AET40442.1 - 1.7e-25 88.6 0.7 2.7e-25 87.9 0.7 1.3 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.6 AET40442.1 - 0.025 14.3 0.0 0.037 13.7 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B UBA_6 PF18039.1 AET40442.1 - 0.038 13.9 0.1 0.07 13.1 0.1 1.5 1 0 0 1 1 1 0 UBA-like domain DUF1421 PF07223.11 AET40442.1 - 0.057 13.3 0.1 0.098 12.5 0.1 1.4 1 0 0 1 1 1 0 UBA-like domain (DUF1421) Calsarcin PF05556.11 AET40442.1 - 0.084 12.4 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Calcineurin-binding protein (Calsarcin) RWD PF05773.22 AET40442.1 - 0.11 12.8 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 RWD domain RGS12_usC PF16612.5 AET40442.1 - 0.12 12.8 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 C-terminal unstructured region of RGS12 MutS_V PF00488.21 AET40443.1 - 1.7e-68 230.4 0.2 7.4e-68 228.3 0.0 2.1 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 AET40443.1 - 1.8e-34 119.6 3.6 2.2e-34 119.3 0.9 2.3 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 AET40443.1 - 9.9e-28 96.6 0.2 2.2e-27 95.6 0.2 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 AET40443.1 - 5e-08 33.3 0.3 4.5e-07 30.2 0.1 2.9 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 AET40443.1 - 1.2e-05 25.5 0.3 1.2e-05 25.5 0.3 2.7 2 0 0 2 2 2 1 MutS family domain IV COMP PF11598.8 AET40443.1 - 0.079 13.4 0.3 0.36 11.4 0.2 2.2 2 0 0 2 2 2 0 Cartilage oligomeric matrix protein NPV_P10 PF05531.12 AET40443.1 - 7.3 7.1 8.3 17 6.0 0.2 4.1 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Pkinase PF00069.25 AET40444.1 - 1.6e-77 260.4 0.0 3e-77 259.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40444.1 - 6.3e-31 107.6 0.0 2.5e-29 102.3 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET40444.1 - 6.7e-06 25.6 0.2 0.0026 17.1 0.0 2.6 1 1 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 AET40444.1 - 0.0027 16.6 0.0 0.0027 16.6 0.0 2.7 2 1 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 AET40444.1 - 0.031 13.6 0.0 0.055 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Trm112p PF03966.16 AET40445.1 - 1.4e-18 67.2 0.1 2.5e-18 66.4 0.1 1.4 1 0 0 1 1 1 1 Trm112p-like protein Tic110 PF16940.5 AET40445.1 - 0.023 13.2 0.1 0.03 12.8 0.1 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter Thiolase_N PF00108.23 AET40446.1 - 1.1e-98 329.8 3.8 1.3e-98 329.5 3.8 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 AET40446.1 - 1.1e-44 151.0 0.3 1.1e-44 151.0 0.3 2.1 2 1 1 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 AET40446.1 - 0.00011 21.8 3.1 0.0002 21.0 2.8 1.7 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 AET40446.1 - 0.042 13.7 0.1 1.6 8.7 0.2 2.5 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Pkinase PF00069.25 AET40447.1 - 1.2e-46 159.2 0.1 5.2e-40 137.5 0.1 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AET40447.1 - 1e-20 74.1 0.1 6.7e-19 68.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 AET40447.1 - 2.8e-06 26.9 0.0 5.3e-06 25.9 0.0 1.4 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 AET40447.1 - 0.024 14.0 0.5 0.039 13.3 0.5 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AET40447.1 - 0.04 13.8 0.2 0.088 12.7 0.2 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family p450 PF00067.22 AET40448.1 - 6.4e-95 318.6 0.0 7.4e-95 318.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pyr_redox_2 PF07992.14 AET40450.1 - 1.2e-46 159.2 0.0 1.5e-46 158.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AET40450.1 - 8.4e-10 39.1 0.0 1.7e-08 34.9 0.0 2.8 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AET40450.1 - 0.0032 16.8 0.0 1.4 8.1 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pox_Ag35 PF03286.14 AET40451.1 - 0.0074 16.1 3.2 0.015 15.1 3.2 1.5 1 0 0 1 1 1 1 Pox virus Ag35 surface protein DUF455 PF04305.14 AET40451.1 - 0.017 14.7 0.1 0.037 13.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF455) CENP-B_dimeris PF09026.10 AET40451.1 - 0.041 14.3 2.2 0.079 13.4 2.2 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain WW_FCH_linker PF16623.5 AET40451.1 - 0.078 13.7 2.0 0.28 12.0 1.4 2.1 2 0 0 2 2 2 0 Unstructured linker region between on GAS7 protein DEAD PF00270.29 AET40452.1 - 1.9e-35 122.2 0.1 3.4e-35 121.4 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET40452.1 - 3.2e-27 95.1 0.2 5.7e-25 87.8 0.1 2.6 2 1 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 AET40452.1 - 3.9e-09 36.7 0.0 8.7e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Ribosomal_S9 PF00380.19 AET40454.1 - 7.9e-33 113.5 0.4 9e-33 113.4 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ribosomal_L13e PF01294.18 AET40455.1 - 1.9e-66 223.3 4.4 3.2e-66 222.6 4.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L13e Ribosomal_60s PF00428.19 AET40456.1 - 1.6e-21 76.6 10.3 2e-21 76.3 10.3 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein zf-C3HC4_3 PF13920.6 AET40457.1 - 0.28 11.1 8.9 0.18 11.7 3.2 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TPP_enzyme_N PF02776.18 AET40458.1 - 1.1e-25 90.3 0.0 1.8e-25 89.6 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 AET40458.1 - 2.1e-21 76.1 0.0 4e-21 75.2 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 AET40458.1 - 3.9e-13 49.5 0.0 1.1e-12 47.9 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Pkinase PF00069.25 AET40459.1 - 1.7e-62 211.2 0.0 2.3e-62 210.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40459.1 - 1.5e-25 90.0 0.0 2.3e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 AET40459.1 - 0.019 14.9 0.0 0.054 13.4 0.0 1.5 1 1 0 2 2 2 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 AET40459.1 - 0.023 14.3 0.1 0.023 14.3 0.1 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase RICTOR_M PF14666.6 AET40459.1 - 0.034 13.9 0.4 0.069 12.9 0.4 1.5 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, middle domain POX PF07526.11 AET40459.1 - 0.3 11.6 1.7 0.96 10.0 1.7 2.0 1 1 0 1 1 1 0 Associated with HOX Macoilin PF09726.9 AET40459.1 - 2.1 6.8 8.9 2.6 6.5 8.9 1.1 1 0 0 1 1 1 0 Macoilin family DRMBL PF07522.14 AET40460.1 - 7.2e-25 87.3 1.0 1.4e-24 86.4 1.0 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 AET40460.1 - 0.00015 21.4 0.0 0.00026 20.6 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain GATA PF00320.27 AET40461.1 - 2e-14 52.9 3.6 3.6e-14 52.1 3.6 1.5 1 0 0 1 1 1 1 GATA zinc finger eIF-3_zeta PF05091.12 AET40461.1 - 0.19 10.7 32.8 0.35 9.8 32.8 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ABC2_membrane_2 PF12679.7 AET40461.1 - 0.22 10.8 2.0 0.45 9.7 2.0 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein GramPos_pilinD1 PF16555.5 AET40461.1 - 0.58 10.3 14.7 1.5 9.0 14.7 1.7 1 0 0 1 1 1 0 Gram-positive pilin subunit D1, N-terminal domain RR_TM4-6 PF06459.12 AET40461.1 - 1.6 8.5 27.1 3.2 7.5 27.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4746 PF15928.5 AET40461.1 - 3 7.2 16.8 6.6 6.1 16.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Tim54 PF11711.8 AET40461.1 - 3.5 6.3 21.7 6.1 5.5 21.7 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Mem_trans PF03547.18 AET40461.1 - 5.2 5.3 4.4 7.7 4.8 4.4 1.2 1 0 0 1 1 1 0 Membrane transport protein FAM176 PF14851.6 AET40461.1 - 8.4 6.0 13.6 23 4.6 13.6 1.8 1 0 0 1 1 1 0 FAM176 family CLTH PF10607.9 AET40462.1 - 1.3e-25 90.0 2.4 1.3e-25 90.0 2.4 1.7 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain Meiotic_rec114 PF03525.14 AET40465.1 - 1.5e-08 34.1 2.4 1.8e-08 33.7 2.4 1.2 1 0 0 1 1 1 1 Meiotic recombination protein rec114 NFACT-R_1 PF05670.13 AET40466.1 - 5.4e-32 110.7 0.0 9.8e-32 109.9 0.0 1.4 1 0 0 1 1 1 1 NFACT protein RNA binding domain Glyco_hydro_17 PF00332.18 AET40466.1 - 0.062 12.9 0.0 0.093 12.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 17 DUF1682 PF07946.14 AET40466.1 - 0.7 9.0 10.0 0.91 8.7 10.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1682) CAF1C_H4-bd PF12265.8 AET40467.1 - 7.4e-14 51.8 0.1 2e-13 50.4 0.1 1.8 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 AET40467.1 - 2.5e-08 34.4 9.7 0.0022 18.8 0.1 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET40467.1 - 1e-05 25.8 1.2 0.13 12.6 0.2 2.8 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ammonium_transp PF00909.21 AET40467.1 - 0.15 10.7 0.0 0.23 10.1 0.0 1.2 1 0 0 1 1 1 0 Ammonium Transporter Family RIC1 PF07064.13 AET40468.1 - 3.2e-15 56.2 0.2 1.2e-14 54.3 0.2 2.0 1 1 0 1 1 1 1 RIC1 COX6B PF02297.17 AET40469.1 - 1e-20 73.8 4.1 1.2e-20 73.5 4.1 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 AET40469.1 - 0.069 13.2 1.5 0.11 12.5 1.5 1.4 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, APOBEC_C PF05240.14 AET40469.1 - 0.085 12.8 0.3 0.11 12.5 0.3 1.3 1 0 0 1 1 1 0 APOBEC-like C-terminal domain HATPase_c_3 PF13589.6 AET40470.1 - 2.1e-10 40.6 0.4 2.4e-09 37.1 0.0 2.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_mis_repair PF01119.19 AET40470.1 - 8.9e-07 28.6 0.1 2.5e-06 27.2 0.1 1.7 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c PF02518.26 AET40470.1 - 0.0008 19.9 0.0 0.0018 18.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Flexi_CP_N PF08358.10 AET40470.1 - 0.36 10.8 1.7 17 5.5 0.2 2.6 2 0 0 2 2 2 0 Carlavirus coat DUF3715 PF12509.8 AET40471.1 - 0.19 11.7 1.3 0.52 10.3 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3715) Y_Y_Y PF07495.13 AET40471.1 - 0.76 9.8 3.7 17 5.4 0.0 3.3 3 0 0 3 3 3 0 Y_Y_Y domain Nramp PF01566.18 AET40472.1 - 1.6e-96 323.4 18.9 2.2e-96 322.9 18.9 1.1 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Bromodomain PF00439.25 AET40473.1 - 8.3e-06 25.8 0.0 2.7e-05 24.2 0.0 1.9 1 0 0 1 1 1 1 Bromodomain HA2 PF04408.23 AET40474.1 - 1.7e-29 102.3 0.0 1.7e-29 102.3 0.0 2.9 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 AET40474.1 - 1.1e-12 48.3 0.2 4.9e-11 43.0 0.0 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 AET40474.1 - 5.3e-11 42.7 0.0 2.2e-10 40.7 0.0 2.1 2 0 0 2 2 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 AET40474.1 - 1.5e-09 37.9 0.0 4.1e-09 36.5 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AET40474.1 - 0.0026 18.0 0.1 0.011 16.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 AET40474.1 - 0.0042 16.2 0.2 0.011 14.8 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein ATPase PF06745.13 AET40474.1 - 0.0072 15.7 0.0 0.0072 15.7 0.0 2.9 4 0 0 4 4 4 1 KaiC AAA_19 PF13245.6 AET40474.1 - 0.0085 16.4 0.0 0.019 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AET40474.1 - 0.017 14.8 0.0 0.047 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 AET40474.1 - 0.034 13.6 0.0 0.097 12.1 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein HTH_37 PF13744.6 AET40474.1 - 0.74 9.8 3.1 0.98 9.4 0.4 2.6 3 0 0 3 3 3 0 Helix-turn-helix domain MOZ_SAS PF01853.18 AET40475.1 - 1.2e-57 194.5 0.1 1.5e-57 194.1 0.1 1.1 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 AET40475.1 - 1.1e-05 24.9 3.6 0.00015 21.3 1.8 2.6 2 0 0 2 2 2 1 MYST family zinc finger domain Acetyltransf_1 PF00583.25 AET40475.1 - 0.0036 17.5 0.0 0.01 16.0 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AET40475.1 - 0.0043 17.4 0.0 0.0083 16.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AET40475.1 - 0.074 13.0 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF4129 PF13559.6 AET40476.1 - 0.00094 19.4 0.0 0.0017 18.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4129) NICE-3 PF07406.11 AET40476.1 - 0.015 15.3 1.1 0.022 14.7 0.1 1.7 2 0 0 2 2 2 0 NICE-3 protein Asp4 PF16996.5 AET40476.1 - 0.13 12.1 0.4 0.26 11.1 0.4 1.4 1 0 0 1 1 1 0 Accessory secretory protein Sec Asp4 MIF4G_like PF09088.11 AET40477.1 - 6.5e-54 182.6 1.8 1.2e-53 181.7 0.6 2.1 2 0 0 2 2 2 1 MIF4G like MIF4G_like_2 PF09090.11 AET40477.1 - 4e-50 170.8 3.4 2.1e-48 165.2 3.4 2.4 1 1 0 1 1 1 1 MIF4G like MIF4G PF02854.19 AET40477.1 - 3.5e-11 43.2 3.0 5.6e-11 42.5 1.6 2.1 2 0 0 2 2 2 1 MIF4G domain Pkr1 PF08636.10 AET40478.1 - 1.2e-28 99.0 7.7 1.5e-28 98.7 7.7 1.1 1 0 0 1 1 1 1 ER protein Pkr1 Kei1 PF08552.11 AET40478.1 - 0.18 11.6 3.4 0.38 10.6 3.4 1.6 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 SSP160 PF06933.11 AET40479.1 - 0.25 9.5 22.2 0.27 9.4 22.2 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF515 PF04415.12 AET40479.1 - 0.54 8.6 9.2 0.59 8.5 9.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF515) FSA_C PF10479.9 AET40479.1 - 2.8 6.0 12.7 3 5.9 12.7 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Macoilin PF09726.9 AET40479.1 - 5.9 5.3 5.1 6.2 5.3 5.1 1.0 1 0 0 1 1 1 0 Macoilin family Ribosomal_L15e PF00827.17 AET40480.1 - 5.9e-89 296.9 13.7 7.3e-89 296.6 13.7 1.0 1 0 0 1 1 1 1 Ribosomal L15 AICARFT_IMPCHas PF01808.18 AET40481.1 - 3.1e-94 315.8 0.0 4.6e-94 315.2 0.0 1.2 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 AET40481.1 - 4.5e-24 84.5 0.9 2.3e-23 82.2 0.0 2.4 3 0 0 3 3 3 1 MGS-like domain zf-C3HC4_3 PF13920.6 AET40482.1 - 2.2e-09 37.0 11.4 5.6e-09 35.7 11.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Cation_ATPase_C PF00689.21 AET40482.1 - 0.012 15.3 1.9 0.012 15.3 1.9 2.0 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus Prok-RING_4 PF14447.6 AET40482.1 - 0.11 12.4 10.7 0.23 11.3 10.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Aminotran_1_2 PF00155.21 AET40483.1 - 5.9e-73 246.1 0.0 7e-73 245.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II SNARE PF05739.19 AET40484.1 - 2.1e-15 56.4 0.6 5.6e-15 55.1 0.6 1.8 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 AET40484.1 - 9.8e-09 35.2 11.9 0.00039 20.1 1.6 2.4 2 0 0 2 2 2 2 Syntaxin DUF1664 PF07889.12 AET40484.1 - 0.0022 18.0 9.7 0.14 12.2 1.1 3.4 2 1 1 3 3 3 2 Protein of unknown function (DUF1664) Syntaxin-18_N PF10496.9 AET40484.1 - 0.0055 16.9 1.5 0.014 15.6 0.5 2.1 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus Syntaxin-5_N PF11416.8 AET40484.1 - 0.0078 15.4 0.0 0.026 13.8 0.0 2.0 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain DUF16 PF01519.16 AET40484.1 - 0.0083 16.6 1.9 0.0083 16.6 1.9 2.3 2 1 0 2 2 2 1 Protein of unknown function DUF16 MCPsignal PF00015.21 AET40484.1 - 0.0085 15.9 0.7 0.0085 15.9 0.7 3.0 2 1 1 3 3 3 1 Methyl-accepting chemotaxis protein (MCP) signalling domain Cluap1 PF10234.9 AET40484.1 - 0.028 13.8 0.7 0.028 13.8 0.7 2.3 2 1 0 2 2 2 0 Clusterin-associated protein-1 V-SNARE PF05008.15 AET40484.1 - 0.06 13.7 3.3 0.13 12.7 1.3 2.6 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Prominin PF05478.11 AET40484.1 - 0.061 11.3 5.9 0.022 12.7 2.8 1.8 1 1 1 2 2 2 0 Prominin DUF3985 PF13153.6 AET40484.1 - 0.17 11.9 1.5 0.29 11.2 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3985) Serine_rich PF08824.10 AET40484.1 - 0.19 11.7 3.8 3.7 7.5 0.1 2.7 2 1 1 3 3 3 0 Serine rich protein interaction domain UPF0242 PF06785.11 AET40484.1 - 0.27 11.3 13.5 0.06 13.4 4.8 2.5 1 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus DUF724 PF05266.14 AET40484.1 - 0.29 10.9 7.0 3.7 7.3 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Corona_S2 PF01601.16 AET40484.1 - 0.7 8.3 5.7 0.11 11.0 2.2 1.6 2 0 0 2 2 2 0 Coronavirus S2 glycoprotein HrpB7 PF09486.10 AET40484.1 - 1 9.8 8.9 0.77 10.1 1.8 2.9 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) Snf7 PF03357.21 AET40485.1 - 3e-52 176.7 12.5 3e-52 176.7 12.5 1.8 2 0 0 2 2 2 1 Snf7 HALZ PF02183.18 AET40486.1 - 0.0017 18.5 1.4 0.0035 17.5 1.4 1.5 1 0 0 1 1 1 1 Homeobox associated leucine zipper ZapB PF06005.12 AET40486.1 - 0.087 13.3 0.9 0.087 13.3 0.9 1.9 3 0 0 3 3 3 0 Cell division protein ZapB DivIC PF04977.15 AET40486.1 - 0.13 12.0 1.2 0.28 11.0 1.2 1.5 1 0 0 1 1 1 0 Septum formation initiator FlaC_arch PF05377.11 AET40486.1 - 0.14 12.5 2.0 0.2 12.1 0.9 1.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) LAMTOR PF15454.6 AET40486.1 - 0.65 10.7 4.1 2.6 8.7 0.1 2.5 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Sdh_cyt PF01127.22 AET40487.1 - 4.9e-28 97.6 1.7 6.1e-28 97.3 1.7 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Pkinase PF00069.25 AET40488.1 - 8e-75 251.6 0.1 1.1e-74 251.2 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40488.1 - 2.4e-33 115.5 0.0 3.3e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AET40488.1 - 2.3e-08 33.4 1.0 6.4e-08 31.9 1.0 1.6 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 AET40488.1 - 2e-05 24.1 0.0 5.1e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 AET40488.1 - 0.0041 16.0 0.2 0.0041 16.0 0.2 1.8 2 1 1 3 3 3 1 Fungal protein kinase APH PF01636.23 AET40488.1 - 0.027 14.4 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family DASH_Hsk3 PF08227.11 AET40489.1 - 4.1e-19 68.6 5.2 5.9e-19 68.2 5.2 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like FAP206 PF12018.8 AET40489.1 - 0.0053 16.3 1.6 0.0061 16.1 1.6 1.0 1 0 0 1 1 1 1 Domain of unknown function FTA4 PF13093.6 AET40489.1 - 0.0092 15.9 0.2 0.01 15.8 0.2 1.2 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF2205 PF10224.9 AET40489.1 - 0.014 15.3 2.5 0.024 14.6 2.6 1.4 1 1 0 1 1 1 0 Short coiled-coil protein Transposase_24 PF03004.14 AET40489.1 - 0.017 15.2 0.1 0.018 15.2 0.1 1.1 1 0 0 1 1 1 0 Plant transposase (Ptta/En/Spm family) TerB_C PF15615.6 AET40489.1 - 0.045 14.0 0.1 0.053 13.8 0.1 1.1 1 0 0 1 1 1 0 TerB-C domain FliD_N PF02465.18 AET40489.1 - 0.058 14.1 2.5 0.064 14.0 2.5 1.1 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus CorA PF01544.18 AET40489.1 - 0.18 11.1 1.3 0.21 10.9 1.3 1.0 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Spc24 PF08286.11 AET40490.1 - 1.2e-19 70.4 2.1 1.2e-19 70.4 2.1 2.3 1 1 1 2 2 2 1 Spc24 subunit of Ndc80 Seryl_tRNA_N PF02403.22 AET40490.1 - 0.26 11.5 13.8 6.1 7.1 11.6 2.8 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FapA PF03961.13 AET40490.1 - 4.6 5.7 7.8 5.7 5.4 7.8 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A LMBR1 PF04791.16 AET40490.1 - 8.3 5.2 7.0 11 4.8 7.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein L31 PF09784.9 AET40491.1 - 6.9e-41 138.8 4.3 1.4e-40 137.8 4.3 1.4 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L31 DUF1639 PF07797.14 AET40491.1 - 0.019 14.9 0.3 0.037 14.0 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1639) Cmc1 PF08583.10 AET40492.1 - 1.2e-20 73.3 2.8 1.6e-20 72.9 2.8 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like COX17 PF05051.13 AET40492.1 - 0.11 12.9 1.3 5.9 7.3 0.1 2.3 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) DUF3128 PF11326.8 AET40492.1 - 0.52 10.7 5.4 17 5.9 5.4 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) Adaptin_N PF01602.20 AET40493.1 - 1.2e-110 370.6 14.7 1.6e-110 370.1 14.7 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 AET40493.1 - 3.8e-48 163.6 4.2 3.8e-48 163.6 4.2 2.7 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 AET40493.1 - 1.5e-10 41.3 1.3 0.0006 20.2 0.0 5.9 5 1 1 6 6 6 3 HEAT repeats HEAT PF02985.22 AET40493.1 - 3.7e-07 29.9 3.7 0.022 15.0 0.0 5.8 6 0 0 6 6 6 2 HEAT repeat Atypical_Card PF18461.1 AET40493.1 - 0.029 14.6 0.3 2 8.7 0.0 3.5 2 1 1 3 3 3 0 Atypical caspase recruitment domain HEAT_EZ PF13513.6 AET40493.1 - 0.87 10.2 5.4 3.3 8.3 0.0 4.6 7 1 1 8 8 8 0 HEAT-like repeat WD40 PF00400.32 AET40494.1 - 9.3e-43 143.4 14.8 3.1e-07 31.0 0.6 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET40494.1 - 9.2e-09 35.5 1.0 0.076 13.3 0.0 4.4 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AET40494.1 - 1.3e-05 24.0 8.7 0.092 11.4 0.2 4.8 2 1 2 5 5 5 2 Nucleoporin Nup120/160 eIF2A PF08662.11 AET40494.1 - 0.00013 21.9 0.4 0.0073 16.2 0.0 2.8 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 AET40494.1 - 0.00015 20.9 0.7 1.4 7.8 0.0 3.8 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 AET40494.1 - 0.11 12.5 0.1 9.9 6.2 0.0 3.5 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Peptidase_M3 PF01432.20 AET40495.1 - 3.1e-131 438.8 0.0 4.7e-131 438.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M91 PF14891.6 AET40495.1 - 0.14 12.5 0.0 0.3 11.4 0.0 1.5 1 0 0 1 1 1 0 Effector protein Peptidase_M50B PF13398.6 AET40495.1 - 0.22 11.2 0.1 0.36 10.4 0.1 1.2 1 0 0 1 1 1 0 Peptidase M50B-like SRAP PF02586.14 AET40496.1 - 1.7e-61 207.6 0.1 2.3e-61 207.1 0.1 1.2 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) DKCLD PF08068.12 AET40496.1 - 0.008 16.2 0.0 0.025 14.6 0.0 1.8 1 0 0 1 1 1 1 DKCLD (NUC011) domain Lipocalin PF00061.23 AET40496.1 - 0.021 15.0 0.2 0.03 14.5 0.2 1.3 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family MxiM PF11441.8 AET40496.1 - 0.091 13.1 0.1 0.17 12.2 0.1 1.4 1 0 0 1 1 1 0 Pilot protein MxiM Mur_ligase_M PF08245.12 AET40497.1 - 4.9e-07 29.9 0.0 7.6e-06 26.0 0.0 2.7 1 1 0 1 1 1 1 Mur ligase middle domain GCR1_C PF12550.8 AET40498.1 - 3.5e-26 91.3 1.2 1.1e-25 89.8 1.2 1.9 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Seryl_tRNA_N PF02403.22 AET40498.1 - 0.013 15.8 3.4 0.04 14.1 3.4 1.9 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Swi5 PF07061.11 AET40498.1 - 0.03 14.4 1.4 0.091 12.9 1.4 1.8 1 0 0 1 1 1 0 Swi5 DUF4061 PF13270.6 AET40498.1 - 0.043 14.1 2.4 0.16 12.3 2.4 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4061) DASH_Dad3 PF08656.10 AET40498.1 - 0.1 12.7 3.7 7.9 6.6 1.0 3.0 1 1 1 2 2 2 0 DASH complex subunit Dad3 FapA PF03961.13 AET40498.1 - 0.11 11.0 3.2 0.17 10.5 3.2 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A BLOC1_2 PF10046.9 AET40498.1 - 0.21 11.9 6.7 8.2 6.8 2.2 2.8 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 She2p PF11435.8 AET40499.1 - 4e-81 271.5 5.6 6.6e-81 270.8 5.6 1.3 1 0 0 1 1 1 1 RNA binding protein She2p Fimbrial_K88 PF02432.15 AET40499.1 - 0.013 15.5 0.0 0.28 11.2 0.0 2.1 2 0 0 2 2 2 0 Fimbrial, major and minor subunit Ku_PK_bind PF08785.11 AET40499.1 - 1.9 8.6 5.7 0.99 9.6 0.5 2.7 2 2 1 3 3 3 0 Ku C terminal domain like Myosin_head PF00063.21 AET40500.1 - 1.1e-232 774.1 5.2 1.3e-232 773.9 5.2 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 AET40500.1 - 1.7e-46 158.2 0.0 3.2e-46 157.4 0.0 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 AET40500.1 - 4.4e-12 45.4 0.0 8.3e-12 44.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AET40500.1 - 2e-08 33.9 0.0 4.1e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AET40500.1 - 5.8e-05 22.7 0.0 0.00013 21.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain AAA_22 PF13401.6 AET40500.1 - 0.04 14.2 0.0 0.14 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 AET40500.1 - 0.064 13.6 0.0 0.19 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 AET40500.1 - 0.087 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Sigma54_activat PF00158.26 AET40500.1 - 0.11 12.2 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Hpr_kinase_C PF07475.12 AET40500.1 - 0.11 12.0 0.1 8.3 5.9 0.0 2.4 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain IQ PF00612.27 AET40500.1 - 8.4 6.5 14.4 1.8 8.5 5.9 2.6 1 1 1 2 2 2 0 IQ calmodulin-binding motif TPP_enzyme_N PF02776.18 AET40501.1 - 6.6e-56 188.6 0.0 7.5e-55 185.2 0.0 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 AET40501.1 - 4.1e-48 163.0 0.4 1.6e-46 157.9 0.1 2.9 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 AET40501.1 - 1.1e-39 135.4 1.5 2.5e-39 134.1 1.5 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain CO_dh PF02552.16 AET40501.1 - 0.017 14.9 0.0 0.031 14.0 0.0 1.3 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit Glyco_tran_WecB PF03808.13 AET40501.1 - 0.077 13.0 0.1 0.75 9.7 0.0 2.5 2 1 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family POR_N PF01855.19 AET40501.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg His_Phos_1 PF00300.22 AET40502.1 - 3.2e-07 30.2 0.2 0.027 14.2 0.0 2.8 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Glyco_hydro_17 PF00332.18 AET40504.1 - 1e-06 28.6 0.1 2.5e-06 27.3 0.1 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 DUF1908 PF08926.11 AET40504.1 - 1.4 7.9 5.2 2 7.4 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1908) SSP160 PF06933.11 AET40504.1 - 7.1 4.7 23.3 11 4.1 23.3 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Mid2 PF04478.12 AET40505.1 - 1.5e-45 154.7 3.0 1.5e-45 154.7 3.0 2.8 3 0 0 3 3 3 1 Mid2 like cell wall stress sensor DUF2407_C PF13373.6 AET40505.1 - 0.14 12.4 0.0 0.31 11.2 0.0 1.6 1 0 0 1 1 1 0 DUF2407 C-terminal domain Stevor PF17410.2 AET40505.1 - 4.4 6.8 5.5 0.55 9.7 0.6 1.9 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame Hid1 PF12722.7 AET40505.1 - 7.8 4.5 10.8 5.7 4.9 9.6 1.3 1 1 0 1 1 1 0 High-temperature-induced dauer-formation protein E1-E2_ATPase PF00122.20 AET40506.1 - 6.4e-48 162.7 0.1 6.4e-48 162.7 0.1 2.3 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 AET40506.1 - 9.5e-46 155.8 0.4 9.5e-46 155.8 0.4 2.4 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 AET40506.1 - 1.9e-20 74.1 0.3 1.5e-19 71.2 0.3 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AET40506.1 - 8.8e-17 61.0 0.0 1.7e-16 60.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 AET40506.1 - 4.8e-13 48.6 0.0 9.8e-13 47.6 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 AET40506.1 - 2e-05 24.5 1.6 0.00029 20.6 1.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 AET40506.1 - 0.11 12.9 0.0 0.27 11.6 0.0 1.7 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase RDD PF06271.12 AET40506.1 - 0.65 10.2 6.3 0.64 10.2 0.2 3.1 3 0 0 3 3 3 0 RDD family Sua5_yciO_yrdC PF01300.18 AET40507.1 - 4.6e-51 172.8 0.0 2.3e-50 170.6 0.0 1.8 2 0 0 2 2 2 1 Telomere recombination SUA5 PF03481.13 AET40507.1 - 3.1e-28 99.0 0.0 4.3e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding FTR1 PF03239.14 AET40508.1 - 2e-90 303.1 10.7 2.3e-90 302.9 10.7 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family DUF4293 PF14126.6 AET40508.1 - 0.012 15.8 7.3 0.62 10.3 2.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4293) Copper-fist PF00649.18 AET40509.1 - 6.7e-21 73.5 0.9 6.7e-21 73.5 0.9 2.0 1 1 0 1 1 1 1 Copper fist DNA binding domain Ran-binding PF05508.11 AET40510.1 - 8.9e-103 343.5 2.8 1.3e-102 343.0 2.8 1.2 1 0 0 1 1 1 1 RanGTP-binding protein CFIA_Pcf11 PF11526.8 AET40510.1 - 0.12 12.9 0.7 0.33 11.5 0.7 1.7 1 0 0 1 1 1 0 Subunit of cleavage factor IA Pcf11 SNF2_N PF00176.23 AET40511.1 - 1.2e-58 198.5 0.0 1.7e-58 198.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 AET40511.1 - 2.9e-41 141.6 0.0 1.3e-40 139.5 0.0 1.9 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.31 AET40511.1 - 8.5e-17 61.5 0.0 7.3e-16 58.5 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET40511.1 - 3.4e-06 27.1 0.0 6.4e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 AET40511.1 - 6.8e-05 22.2 0.0 0.00039 19.7 0.0 2.0 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Zn_clus PF00172.18 AET40515.1 - 0.0012 19.0 11.9 0.002 18.2 2.5 2.4 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain RNA_pol_I_TF PF04090.12 AET40517.1 - 0.016 14.7 0.1 0.031 13.8 0.1 1.4 1 0 0 1 1 1 0 RNA polymerase I specific initiation factor PBECR5 PF18814.1 AET40517.1 - 0.082 12.8 1.0 0.1 12.5 1.0 1.2 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease5 Csm2_III-A PF03750.13 AET40517.1 - 1.3 9.9 6.0 0.87 10.4 0.4 2.3 2 1 0 2 2 2 0 Csm2 Type III-A Rad21_Rec8_N PF04825.13 AET40518.1 - 5.8e-15 55.4 0.0 1.3e-14 54.2 0.0 1.6 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Bromodomain PF00439.25 AET40519.1 - 1.2e-32 111.8 8.7 4.7e-24 84.3 1.6 2.6 2 0 0 2 2 2 2 Bromodomain DUF1810 PF08837.11 AET40519.1 - 0.0023 17.7 0.1 0.0064 16.3 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1810) LAMTOR PF15454.6 AET40520.1 - 2.1e-21 76.3 4.3 2.7e-21 75.9 4.3 1.2 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Ribosomal_L50 PF10501.9 AET40521.1 - 1.8e-27 95.6 0.2 4.5e-27 94.4 0.1 1.7 2 0 0 2 2 2 1 Ribosomal subunit 39S DUF4042 PF13251.6 AET40523.1 - 0.044 13.5 0.2 0.42 10.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4042) Oxysterol_BP PF01237.18 AET40524.1 - 1.1e-81 274.5 0.0 9.8e-80 268.2 0.0 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein eIF2A PF08662.11 AET40525.1 - 8.3e-74 247.7 0.0 2.3e-72 243.0 0.0 2.3 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 AET40525.1 - 0.01 16.7 0.0 11 7.0 0.1 4.2 3 1 1 4 4 4 0 WD domain, G-beta repeat MMU163 PF17119.5 AET40526.1 - 1.6e-09 37.3 1.5 5e-07 29.1 1.5 2.7 1 1 0 1 1 1 1 Mitochondrial protein up-regulated during meiosis Pkinase PF00069.25 AET40527.1 - 1.1e-51 175.7 0.0 1.7e-51 175.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40527.1 - 3e-32 111.9 0.0 4.4e-32 111.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET40527.1 - 8.5e-09 35.1 0.0 4.9e-07 29.3 0.0 2.2 1 1 1 2 2 2 2 Kinase-like Kdo PF06293.14 AET40527.1 - 0.0051 16.2 0.0 0.0088 15.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AET40527.1 - 0.014 15.3 0.0 0.04 13.8 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family IlvN PF07991.12 AET40529.1 - 2.7e-45 153.9 0.0 3.8e-45 153.4 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 AET40529.1 - 2.7e-41 141.2 0.0 6.7e-41 139.9 0.0 1.6 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.15 AET40529.1 - 0.012 15.7 0.0 0.03 14.5 0.0 1.6 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 AET40529.1 - 0.11 13.0 0.0 0.26 11.9 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent TatD_DNase PF01026.21 AET40529.1 - 0.21 10.9 0.0 0.47 9.8 0.0 1.5 2 0 0 2 2 2 0 TatD related DNase AhpC-TSA PF00578.21 AET40530.1 - 9.3e-28 96.6 0.0 1.2e-27 96.3 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AET40530.1 - 9.1e-10 38.4 0.0 1.3e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 AET40530.1 - 4.6e-05 23.2 0.0 8.2e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin TAL_FSA PF00923.19 AET40531.1 - 1.5e-99 333.0 0.1 1.7e-99 332.8 0.1 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Zn_clus PF00172.18 AET40532.1 - 8.2e-09 35.5 10.2 8.2e-09 35.5 10.2 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2439 PF10382.9 AET40533.1 - 7.6e-22 77.4 0.3 1.3e-21 76.6 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) LRR_4 PF12799.7 AET40535.1 - 0.0027 18.1 8.8 0.034 14.6 0.4 4.9 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) F-box-like PF12937.7 AET40535.1 - 0.0033 17.3 0.4 0.35 10.8 0.0 2.7 2 0 0 2 2 2 1 F-box-like LRR_1 PF00560.33 AET40535.1 - 0.085 13.5 3.1 68 4.6 0.0 5.6 4 1 0 4 4 4 0 Leucine Rich Repeat F-box PF00646.33 AET40535.1 - 0.094 12.6 0.2 11 6.0 0.0 3.0 3 0 0 3 3 3 0 F-box domain LRR_8 PF13855.6 AET40535.1 - 0.17 11.7 2.3 0.87 9.4 0.6 3.0 3 0 0 3 3 3 0 Leucine rich repeat Pkinase PF00069.25 AET40536.1 - 3.3e-69 233.2 0.0 4.2e-69 232.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40536.1 - 1.4e-33 116.3 0.0 2.1e-33 115.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 AET40536.1 - 1.4e-05 24.5 0.1 2.4e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 AET40536.1 - 2.7e-05 23.6 0.0 4.9e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 AET40536.1 - 0.00018 20.6 0.1 0.00027 20.0 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 AET40536.1 - 0.0087 15.7 0.1 0.017 14.7 0.1 1.6 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 AET40536.1 - 0.016 15.1 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family CN_hydrolase PF00795.22 AET40537.1 - 1.4e-57 195.1 0.0 1.5e-57 194.9 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF763 PF05559.11 AET40537.1 - 0.085 12.0 0.0 0.23 10.6 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF763) DUF1415 PF07209.12 AET40537.1 - 0.18 11.6 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1415) ORMDL PF04061.14 AET40538.1 - 9.9e-56 187.3 4.9 1.2e-55 187.1 4.9 1.0 1 0 0 1 1 1 1 ORMDL family ACBP PF00887.19 AET40539.1 - 7.4e-29 99.8 1.0 8.3e-29 99.6 1.0 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein FERM_M PF00373.18 AET40539.1 - 0.0067 16.8 0.1 0.28 11.6 0.0 2.0 1 1 1 2 2 2 2 FERM central domain HEAT PF02985.22 AET40540.1 - 1.1e-14 53.2 18.4 0.00033 20.7 0.1 10.6 11 0 0 11 11 10 3 HEAT repeat IBN_N PF03810.19 AET40540.1 - 1.4e-10 40.9 1.0 1.4e-10 40.9 1.0 3.3 4 0 0 4 4 4 1 Importin-beta N-terminal domain HEAT_EZ PF13513.6 AET40540.1 - 8.2e-10 39.0 11.5 1.2e-07 32.0 0.0 7.2 6 2 2 8 8 7 1 HEAT-like repeat DUF3385 PF11865.8 AET40540.1 - 6.3e-06 26.2 3.3 1.1 9.1 0.7 5.1 2 2 1 3 3 3 3 Domain of unknown function (DUF3385) Cnd1 PF12717.7 AET40540.1 - 6.7e-06 26.2 14.5 0.26 11.3 0.0 5.6 3 2 2 5 5 5 3 non-SMC mitotic condensation complex subunit 1 SIL1 PF16782.5 AET40540.1 - 5.2e-05 22.6 0.9 0.00016 21.0 0.9 1.8 1 0 0 1 1 1 1 Nucleotide exchange factor SIL1 CLASP_N PF12348.8 AET40540.1 - 8.2e-05 22.3 5.1 0.34 10.4 0.0 5.0 6 0 0 6 6 6 2 CLASP N terminal HEAT_2 PF13646.6 AET40540.1 - 0.00012 22.4 7.5 1.4 9.4 0.0 6.9 4 2 6 10 10 10 1 HEAT repeats Arm PF00514.23 AET40540.1 - 0.00019 21.3 9.7 0.0071 16.4 0.1 5.4 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat DUF3347 PF11827.8 AET40540.1 - 0.008 16.4 1.0 0.008 16.4 1.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3347) Caskin-tail PF16632.5 AET40540.1 - 0.033 14.6 0.0 2.5 8.6 0.0 3.6 4 0 0 4 4 4 0 C-terminal region of Caskin RICTOR_V PF14668.6 AET40540.1 - 0.054 13.7 0.1 9.2 6.6 0.0 4.0 4 0 0 4 4 3 0 Rapamycin-insensitive companion of mTOR, domain 5 Sec7_N PF12783.7 AET40540.1 - 0.06 13.3 4.2 0.18 11.7 1.3 3.1 2 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal RTP1_C1 PF10363.9 AET40540.1 - 0.1 12.8 6.8 28 4.9 0.4 5.7 5 1 2 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 PAP2 PF01569.21 AET40541.1 - 7.9e-19 67.8 2.6 1.6e-18 66.8 2.6 1.5 1 0 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.14 AET40541.1 - 0.14 12.2 0.5 3.1 7.9 0.0 2.4 1 1 1 2 2 2 0 Divergent PAP2 family 6PF2K PF01591.18 AET40542.1 - 1.6e-62 210.7 1.0 2.3e-62 210.2 1.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 AET40542.1 - 4.8e-17 62.3 0.0 5.1e-16 58.9 0.0 2.4 1 1 1 2 2 2 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 AET40542.1 - 0.066 13.4 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain Ribosomal_L26 PF16906.5 AET40543.1 - 6.9e-37 125.8 2.5 9.2e-37 125.4 2.5 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 AET40543.1 - 0.0002 21.2 1.4 0.00025 20.9 0.3 1.7 2 0 0 2 2 2 1 KOW motif TIM21 PF08294.11 AET40544.1 - 1.8e-56 190.1 0.7 2.6e-56 189.5 0.1 1.5 2 0 0 2 2 2 1 TIM21 SPRY PF00622.28 AET40544.1 - 0.0026 17.9 0.1 2.6 8.2 0.0 2.2 2 0 0 2 2 2 2 SPRY domain DUF374 PF04028.13 AET40544.1 - 0.088 12.4 0.6 14 5.3 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF374) Glyco_hydro_72 PF03198.14 AET40545.1 - 7.6e-138 459.0 0.8 1e-137 458.6 0.8 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 AET40545.1 - 1.2e-12 48.3 0.4 2.9e-12 47.1 0.4 1.6 1 0 0 1 1 1 1 X8 domain Glucan_synthase PF02364.15 AET40546.1 - 0 1353.2 0.1 0 1352.3 0.0 1.5 2 0 0 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 AET40546.1 - 3.9e-42 143.6 0.3 1.1e-41 142.2 0.3 1.8 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 YMF19 PF02326.15 AET40546.1 - 0.35 11.7 0.1 0.35 11.7 0.1 3.7 5 0 0 5 5 5 0 Plant ATP synthase F0 Ribosomal_L10 PF00466.20 AET40547.1 - 3.8e-25 87.9 0.1 7.2e-25 87.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 AET40547.1 - 7.7e-22 77.1 0.0 1.3e-21 76.4 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 AET40547.1 - 1.4e-17 64.0 2.3 1.4e-17 64.0 2.3 1.8 2 0 0 2 2 2 1 60s Acidic ribosomal protein Alba PF01918.21 AET40548.1 - 6.3e-06 25.9 0.0 1.1e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Alba tRNA_int_endo PF01974.17 AET40549.1 - 3.9e-12 46.1 0.0 9.5e-12 44.8 0.0 1.6 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain Cation_ATPase_C PF00689.21 AET40550.1 - 1.8e-42 145.1 5.5 1.8e-42 145.1 5.5 2.4 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 AET40550.1 - 7.3e-36 123.4 0.6 7.3e-36 123.4 0.6 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 AET40550.1 - 1.1e-18 67.1 0.1 2.7e-18 65.8 0.1 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 AET40550.1 - 8.9e-15 55.5 0.1 1.3e-13 51.7 0.1 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 AET40550.1 - 1.1e-10 41.1 0.0 2.9e-10 39.7 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 AET40550.1 - 5.9e-05 22.9 0.8 0.00044 20.1 0.5 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase COG5 PF10392.9 AET40551.1 - 0.00098 19.3 6.8 0.001 19.3 3.3 2.5 2 1 0 2 2 2 1 Golgi transport complex subunit 5 CENP-F_leu_zip PF10473.9 AET40551.1 - 0.037 14.1 4.4 0.1 12.6 3.3 2.3 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Vps4_C PF09336.10 AET40551.1 - 0.15 12.1 0.2 0.47 10.5 0.2 2.0 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain MscS_porin PF12795.7 AET40551.1 - 0.64 9.5 5.0 0.41 10.2 0.1 2.1 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain DUF1878 PF08963.10 AET40551.1 - 2 9.0 7.6 3.2 8.3 0.1 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF1878) WD40 PF00400.32 AET40552.1 - 2.1e-13 50.5 5.8 4.6e-06 27.3 0.0 5.0 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET40552.1 - 5.8e-05 23.3 0.0 0.32 11.3 0.0 4.0 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AET40552.1 - 0.035 14.0 0.0 2.5 7.9 0.0 2.5 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Rep_fac-A_C PF08646.10 AET40553.1 - 3.9e-61 205.1 1.5 4.9e-58 195.0 1.1 2.5 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 AET40553.1 - 8.3e-34 115.4 1.2 2.4e-29 101.1 0.0 4.0 4 0 0 4 4 4 2 Replication protein A OB domain tRNA_anti-codon PF01336.25 AET40553.1 - 1.6e-20 72.8 1.7 7.9e-10 38.6 0.0 5.0 5 0 0 5 5 5 4 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 AET40553.1 - 1.9e-06 27.8 0.5 0.0012 18.6 0.1 3.4 4 0 0 4 4 4 1 Cell division control protein 24, OB domain 3 Rep-A_N PF04057.12 AET40553.1 - 0.00063 19.7 0.2 0.0025 17.8 0.0 2.1 2 0 0 2 2 2 1 Replication factor-A protein 1, N-terminal domain WD40 PF00400.32 AET40554.1 - 1.7e-20 72.9 10.0 0.0011 19.7 0.0 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET40554.1 - 1.6e-18 66.8 6.1 2.2e-10 40.7 0.4 3.9 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AET40554.1 - 0.00016 21.7 0.1 0.0099 15.8 0.1 2.7 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 AET40554.1 - 0.02 13.9 0.0 0.58 9.1 0.0 2.5 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 AET40555.1 - 9.4e-12 45.3 5.9 0.0002 22.1 0.7 5.3 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET40555.1 - 2.7e-07 30.8 0.1 0.0044 17.3 0.0 3.5 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 AET40555.1 - 0.0043 15.6 0.0 0.009 14.6 0.0 1.5 1 0 0 1 1 1 1 Cytochrome D1 heme domain Lgl_C PF08596.10 AET40555.1 - 0.008 14.9 0.1 0.17 10.6 0.0 2.3 2 0 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal EMP24_GP25L PF01105.24 AET40556.1 - 2.9e-45 154.4 1.4 3.4e-45 154.2 1.4 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SdrD_B PF17210.3 AET40556.1 - 0.032 14.5 0.1 0.048 13.9 0.1 1.4 1 0 0 1 1 1 0 SdrD B-like domain B-block_TFIIIC PF04182.12 AET40559.1 - 2.8e-17 62.6 0.0 7.1e-17 61.3 0.0 1.8 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC AAA_assoc PF14363.6 AET40559.1 - 0.003 17.9 0.0 0.91 9.9 0.0 3.0 2 0 0 2 2 2 1 Domain associated at C-terminal with AAA PheRS_DBD1 PF18552.1 AET40559.1 - 0.11 12.2 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 PheRS DNA binding domain 1 TA_inhibitor PF17574.2 AET40559.1 - 2.4 8.2 6.4 3.5 7.7 0.1 3.2 3 0 0 3 3 3 0 Inhibitor of toxin/antitoxin system (Gp4.5) N6-adenineMlase PF10237.9 AET40560.1 - 2.1e-56 190.2 0.1 3e-56 189.7 0.1 1.2 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase 3Beta_HSD PF01073.19 AET40561.1 - 4.9e-85 284.9 0.0 5.9e-85 284.7 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 AET40561.1 - 3.2e-25 89.0 0.0 4.2e-25 88.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 AET40561.1 - 2e-15 57.0 0.0 6.8e-15 55.3 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 AET40561.1 - 1.7e-12 47.1 0.0 2.8e-11 43.1 0.0 2.3 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 AET40561.1 - 4.8e-08 32.4 0.0 7.6e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 AET40561.1 - 3.2e-07 30.4 0.0 4.8e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 AET40561.1 - 3.3e-06 26.5 0.0 8.2e-06 25.2 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 AET40561.1 - 0.00095 19.1 0.0 0.0041 17.1 0.0 1.9 1 1 0 1 1 1 1 KR domain Phage_TAC_6 PF09550.10 AET40561.1 - 0.12 12.8 0.1 1.5 9.3 0.0 2.2 2 0 0 2 2 2 0 Phage tail assembly chaperone protein, TAC Bradykinin PF06753.12 AET40561.1 - 1.8 8.4 4.7 0.29 10.9 0.3 2.0 2 0 0 2 2 2 0 Bradykinin Vps8 PF12816.7 AET40562.1 - 3.8e-54 183.2 4.2 2.6e-53 180.5 4.4 2.3 2 0 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 zf-C3HC4 PF00097.25 AET40562.1 - 0.0038 17.1 2.3 0.0038 17.1 2.3 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) PPR PF01535.20 AET40562.1 - 0.0053 16.9 0.5 8.4 6.9 0.0 4.1 4 0 0 4 4 3 1 PPR repeat ANAPC4_WD40 PF12894.7 AET40562.1 - 0.014 15.7 1.0 4.6 7.6 0.0 2.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain zf-C3HC4_2 PF13923.6 AET40562.1 - 0.02 14.7 2.8 0.099 12.5 2.8 2.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Clathrin PF00637.20 AET40562.1 - 0.047 13.6 10.8 0.93 9.4 0.2 4.2 5 0 0 5 5 5 0 Region in Clathrin and VPS PHD PF00628.29 AET40562.1 - 0.049 13.5 1.8 0.18 11.7 1.8 1.9 1 0 0 1 1 1 0 PHD-finger zf-RING_UBOX PF13445.6 AET40562.1 - 0.075 13.1 1.9 0.36 10.9 0.4 2.6 2 0 0 2 2 2 0 RING-type zinc-finger C1_1 PF00130.22 AET40562.1 - 0.29 11.0 2.6 20 5.1 1.0 2.8 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-rbx1 PF12678.7 AET40562.1 - 1.7 9.0 4.7 1.1 9.6 1.8 2.2 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_2 PF13639.6 AET40562.1 - 1.8 8.9 9.3 0.061 13.7 1.6 2.7 3 0 0 3 3 2 0 Ring finger domain zf-RING_5 PF14634.6 AET40562.1 - 2 8.4 10.9 0.15 12.0 5.5 2.1 2 1 0 2 2 2 0 zinc-RING finger domain EF1_GNE PF00736.19 AET40563.1 - 8.2e-31 106.0 0.8 1.6e-30 105.1 0.8 1.5 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 AET40563.1 - 2.1e-12 47.2 6.1 2.1e-12 47.2 6.1 2.8 3 0 0 3 3 3 1 Eukaryotic elongation factor 1 beta central acidic region IFT57 PF10498.9 AET40563.1 - 0.0058 15.7 1.9 0.0078 15.2 1.9 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 GST_C_2 PF13410.6 AET40563.1 - 0.019 15.0 0.2 0.39 10.8 0.2 2.5 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 AET40563.1 - 0.24 11.6 5.4 0.66 10.2 0.7 3.0 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain SNF5 PF04855.12 AET40564.1 - 9e-51 173.0 2.0 2.4e-29 102.8 0.1 2.4 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 zf-ribbon_3 PF13248.6 AET40565.1 - 1.3 8.6 4.8 13 5.4 0.2 2.5 2 0 0 2 2 2 0 zinc-ribbon domain CHD5 PF04420.14 AET40566.1 - 1.4e-34 119.2 0.8 1.9e-34 118.8 0.8 1.1 1 0 0 1 1 1 1 CHD5-like protein UCH PF00443.29 AET40567.1 - 2.6e-61 207.4 2.2 2.6e-61 207.4 2.2 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AET40567.1 - 3.2e-17 63.1 5.8 2.1e-16 60.4 5.8 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 AET40567.1 - 2.4e-06 28.0 0.0 5.2e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain zf-MIZ PF02891.20 AET40567.1 - 0.021 14.5 0.6 0.021 14.5 0.6 2.1 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger BSD PF03909.17 AET40568.1 - 2.2e-11 43.6 4.5 5.1e-11 42.4 0.0 3.1 2 1 0 2 2 2 1 BSD domain FliT PF05400.13 AET40568.1 - 0.082 13.7 7.0 1.2 10.0 0.8 3.4 3 0 0 3 3 3 0 Flagellar protein FliT Y_phosphatase2 PF03162.13 AET40569.1 - 4e-54 182.6 0.5 4.9e-54 182.4 0.5 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 AET40569.1 - 0.0065 16.3 0.1 0.0085 15.9 0.1 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Asp_protease PF09668.10 AET40570.1 - 1.1e-53 180.3 0.1 1.8e-53 179.5 0.1 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 AET40570.1 - 1.4e-20 73.6 0.4 3.1e-20 72.5 0.1 1.8 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 AET40570.1 - 4.1e-10 40.2 0.1 8.9e-10 39.1 0.1 1.6 1 0 0 1 1 1 1 Aspartyl protease UBA PF00627.31 AET40570.1 - 1.2e-05 25.0 0.1 3.2e-05 23.7 0.1 1.8 1 0 0 1 1 1 1 UBA/TS-N domain RVP PF00077.20 AET40570.1 - 4.2e-05 23.8 0.2 0.00014 22.2 0.1 1.9 2 0 0 2 2 2 1 Retroviral aspartyl protease RVP_2 PF08284.11 AET40570.1 - 0.00024 20.9 0.0 0.00044 20.0 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RNA_pol_Rpb5_C PF01191.19 AET40570.1 - 0.049 13.5 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase Rpb5, C-terminal domain UBA_2 PF08587.11 AET40570.1 - 0.091 12.9 0.1 3.7 7.7 0.0 2.6 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) Glyco_hydro_6 PF01341.17 AET40570.1 - 0.13 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 6 HhH-GPD PF00730.25 AET40571.1 - 1.7e-11 44.5 0.0 2.7e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Pre-PUA PF17832.1 AET40571.1 - 0.073 13.8 0.1 3.7 8.3 0.0 2.7 2 1 0 2 2 2 0 Pre-PUA-like domain COX15-CtaA PF02628.15 AET40572.1 - 2e-117 391.9 1.5 2.4e-117 391.6 1.5 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein ExoD PF06055.12 AET40572.1 - 0.058 12.8 3.0 0.079 12.3 1.1 2.2 2 0 0 2 2 2 0 Exopolysaccharide synthesis, ExoD DUF2427 PF10348.9 AET40572.1 - 0.1 12.4 0.6 0.36 10.7 0.6 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) Lon_C PF05362.13 AET40573.1 - 5.3e-67 225.3 0.0 1.7e-66 223.7 0.0 1.9 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 AET40573.1 - 1.3e-35 123.2 1.2 1.3e-35 123.2 1.2 2.1 3 0 0 3 3 3 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 AET40573.1 - 5.6e-23 81.8 0.0 2e-22 80.0 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 AET40573.1 - 2.6e-06 27.7 0.0 8.3e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ChlI PF13541.6 AET40573.1 - 9e-06 25.5 0.0 2.5e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 AET40573.1 - 9.4e-06 25.7 0.0 2.1e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AET40573.1 - 8.2e-05 22.9 0.1 0.0021 18.3 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AET40573.1 - 0.0008 19.8 0.1 0.01 16.2 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 AET40573.1 - 0.0011 18.7 0.2 0.01 15.6 0.0 2.7 4 1 0 4 4 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_PrkA PF08298.11 AET40573.1 - 0.0022 17.0 0.0 0.0042 16.0 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain AAA_14 PF13173.6 AET40573.1 - 0.0027 17.7 0.0 0.013 15.6 0.0 2.2 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 AET40573.1 - 0.0051 17.4 0.0 0.025 15.2 0.0 2.3 1 0 0 1 1 1 1 AAA domain ClpB_D2-small PF10431.9 AET40573.1 - 0.0069 16.4 0.2 0.0069 16.4 0.2 2.3 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein RNA_helicase PF00910.22 AET40573.1 - 0.0083 16.5 0.0 0.1 13.0 0.0 2.7 2 0 0 2 2 2 1 RNA helicase IstB_IS21 PF01695.17 AET40573.1 - 0.011 15.5 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_30 PF13604.6 AET40573.1 - 0.031 14.0 0.0 0.18 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 AET40573.1 - 0.037 13.9 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase SKI PF01202.22 AET40573.1 - 0.059 13.5 1.6 0.095 12.8 0.0 2.2 2 0 0 2 2 2 0 Shikimate kinase AAA_7 PF12775.7 AET40573.1 - 0.069 12.7 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 AET40573.1 - 0.099 12.7 1.6 6.2 6.9 0.0 3.3 3 0 0 3 3 3 0 50S ribosome-binding GTPase TsaE PF02367.17 AET40573.1 - 0.15 12.1 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.18 AET40573.1 - 0.21 11.3 1.0 3.3 7.4 0.0 2.3 1 1 1 2 2 2 0 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.27 AET40573.1 - 2.1 8.9 4.9 1 9.9 0.1 2.8 3 0 0 3 3 3 0 ABC transporter CBFD_NFYB_HMF PF00808.23 AET40574.1 - 7.5e-26 90.2 0.1 1.1e-25 89.6 0.1 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 AET40574.1 - 1.6e-05 25.3 0.1 1.6e-05 25.3 0.1 2.2 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 LepB_N PF18640.1 AET40574.1 - 0.018 14.6 0.2 0.034 13.8 0.2 1.3 1 1 0 1 1 1 0 LepB N-terminal domain Bromo_TP PF07524.13 AET40574.1 - 0.026 14.5 0.0 0.26 11.3 0.0 2.2 2 0 0 2 2 2 0 Bromodomain associated CENP-T_C PF15511.6 AET40574.1 - 0.044 13.9 0.0 0.074 13.2 0.0 1.4 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold TFIID_20kDa PF03847.13 AET40574.1 - 0.063 13.8 0.4 0.16 12.5 0.1 1.8 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A CENP-X PF09415.10 AET40574.1 - 0.17 12.2 1.9 0.47 10.8 0.0 2.3 2 0 0 2 2 2 0 CENP-S associating Centromere protein X Rft-1 PF04506.13 AET40575.1 - 2e-205 683.4 36.1 2.3e-205 683.2 36.1 1.0 1 0 0 1 1 1 1 Rft protein YpmT PF17431.2 AET40575.1 - 0.89 9.6 9.3 8.1 6.6 2.4 3.4 2 0 0 2 2 2 0 Uncharacterized YmpT-like Exo_endo_phos PF03372.23 AET40576.1 - 1.3e-12 47.8 0.0 2.3e-12 46.9 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Sortilin-Vps10 PF15902.5 AET40578.1 - 5.7e-195 648.3 12.9 1.2e-134 449.4 1.7 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 AET40578.1 - 4.4e-60 202.9 12.9 1.2e-36 126.6 2.3 2.5 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 AET40578.1 - 1.4e-11 42.5 35.4 0.78 10.0 0.1 11.6 12 0 0 12 12 12 6 BNR/Asp-box repeat BNR_2 PF13088.6 AET40578.1 - 1e-05 25.0 0.1 3.5 6.9 0.0 4.8 3 1 3 6 6 6 3 BNR repeat-like domain PSII_BNR PF14870.6 AET40578.1 - 0.00033 20.0 3.5 0.49 9.6 0.0 4.8 5 1 1 6 6 6 1 Photosynthesis system II assembly factor YCF48 CHB_HEX_C PF03174.13 AET40578.1 - 0.062 13.3 6.3 0.32 11.0 0.1 4.4 6 0 0 6 6 6 0 Chitobiase/beta-hexosaminidase C-terminal domain BNR_6 PF15899.5 AET40578.1 - 0.34 11.1 8.8 1.9 8.8 0.0 5.4 6 0 0 6 6 6 0 BNR-Asp box repeat Pkinase PF00069.25 AET40579.1 - 2.6e-68 230.2 0.0 3.1e-68 230.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40579.1 - 4e-32 111.5 0.0 5e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AET40579.1 - 0.00051 19.1 1.6 0.0017 17.4 1.6 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 AET40579.1 - 0.03 13.7 0.2 0.055 12.8 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family AcetylCoA_hydro PF02550.15 AET40580.1 - 1.3e-63 214.6 0.0 2e-63 214.0 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.6 AET40580.1 - 1.7e-40 138.5 0.0 2.8e-40 137.8 0.0 1.4 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain CitF PF04223.12 AET40580.1 - 0.0011 18.0 0.1 0.0073 15.3 0.1 1.9 2 0 0 2 2 2 1 Citrate lyase, alpha subunit (CitF) CoA_trans PF01144.23 AET40580.1 - 0.019 14.3 0.0 0.091 12.2 0.0 2.1 2 0 0 2 2 2 0 Coenzyme A transferase Acid_PPase PF12689.7 AET40581.1 - 9.4e-40 136.2 0.0 2.5e-39 134.8 0.0 1.6 1 1 0 1 1 1 1 Acid Phosphatase DUF2046 PF09755.9 AET40582.1 - 0.019 14.2 0.2 0.031 13.5 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) Macoilin PF09726.9 AET40582.1 - 0.94 8.0 2.4 1.3 7.5 2.4 1.2 1 0 0 1 1 1 0 Macoilin family FANCL_C PF11793.8 AET40583.1 - 9.3e-05 22.5 11.1 6.7 7.0 0.1 5.4 5 0 0 5 5 5 4 FANCL C-terminal domain CxC4 PF18717.1 AET40583.1 - 0.0033 17.3 23.4 1.2 9.0 0.2 6.5 5 1 0 6 6 6 3 CxC4 like cysteine cluster associated with KDZ transposases VP_N-CPKC PF11475.8 AET40583.1 - 0.012 15.5 18.9 2.2 8.3 0.2 5.6 6 0 0 6 6 6 0 Virion protein N terminal domain RRM_1 PF00076.22 AET40584.1 - 3.2e-44 148.6 0.0 4.7e-21 74.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AET40584.1 - 0.00039 20.0 0.0 0.65 9.6 0.0 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AET40584.1 - 0.0021 18.2 0.0 4.3 7.5 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif DbpA PF03880.15 AET40584.1 - 0.0082 16.1 0.0 0.76 9.8 0.0 2.3 2 0 0 2 2 2 1 DbpA RNA binding domain Nup35_RRM_2 PF14605.6 AET40584.1 - 0.014 15.4 0.1 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Arrestin_N PF00339.29 AET40585.1 - 7.2e-22 78.0 0.0 1.4e-21 77.1 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 AET40585.1 - 1.1e-06 29.1 0.2 6.5e-06 26.6 0.0 2.3 2 2 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain RNase_PH PF01138.21 AET40586.1 - 6.5e-21 75.2 0.0 1e-20 74.6 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 PEMT PF04191.13 AET40587.1 - 2.2e-54 182.4 19.0 1e-31 109.4 2.9 3.4 3 0 0 3 3 3 2 Phospholipid methyltransferase HECW_N PF16562.5 AET40587.1 - 0.0037 17.1 0.1 0.01 15.6 0.1 1.7 1 0 0 1 1 1 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 SKICH PF17751.1 AET40587.1 - 0.023 15.2 0.7 0.51 10.9 0.7 2.6 1 1 0 1 1 1 0 SKICH domain ICMT PF04140.14 AET40587.1 - 1.3 9.5 8.0 1.6 9.2 0.5 3.3 3 0 0 3 3 3 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Septin PF00735.18 AET40588.1 - 4.7e-109 364.0 9.5 5.4e-101 337.6 0.2 2.6 3 0 0 3 3 3 2 Septin MMR_HSR1 PF01926.23 AET40588.1 - 0.00018 21.5 5.0 0.031 14.4 0.1 3.1 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_16 PF13191.6 AET40588.1 - 0.0033 17.8 0.5 0.018 15.4 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain Exonuc_VII_L PF02601.15 AET40588.1 - 0.04 13.5 12.8 0.064 12.8 12.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_22 PF13401.6 AET40588.1 - 0.052 13.8 1.7 0.12 12.6 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 AET40588.1 - 0.11 12.7 0.0 0.27 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 AET40588.1 - 0.95 9.5 11.8 6.6 6.8 0.1 3.7 3 1 0 3 3 3 0 Dynamin family Strep_SA_rep PF06696.11 AET40588.1 - 0.98 9.5 8.6 0.17 11.9 1.6 2.4 2 0 0 2 2 2 0 Streptococcal surface antigen repeat AIG1 PF04548.16 AET40588.1 - 1 8.7 7.4 1.6 8.0 0.0 3.1 3 0 0 3 3 3 0 AIG1 family FapA PF03961.13 AET40588.1 - 1.2 7.6 14.9 2.2 6.8 14.9 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF2852 PF11014.8 AET40588.1 - 5.6 7.2 7.2 0.85 9.8 1.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2852) ABC_tran PF00005.27 AET40588.1 - 6.2 7.3 9.5 1.9 9.0 0.9 2.9 2 1 0 2 2 2 0 ABC transporter SHNi-TPR PF10516.9 AET40589.1 - 2.8e-20 71.5 4.9 5.1e-18 64.2 1.9 2.6 2 0 0 2 2 2 2 SHNi-TPR TPR_12 PF13424.6 AET40589.1 - 0.00048 20.4 11.5 0.021 15.1 0.3 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 AET40589.1 - 0.004 17.0 1.1 0.32 10.9 0.0 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 AET40589.1 - 0.0096 16.1 6.7 0.23 11.7 0.1 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 AET40589.1 - 0.073 13.2 0.1 0.073 13.2 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 AET40589.1 - 0.097 12.5 5.4 0.31 10.9 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat SURF6 PF04935.12 AET40589.1 - 0.1 12.4 1.3 0.19 11.5 1.3 1.4 1 0 0 1 1 1 0 Surfeit locus protein 6 TPR_6 PF13174.6 AET40589.1 - 3.1 8.6 4.8 27 5.7 0.6 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 AET40589.1 - 4.6 7.4 12.1 1.2 9.2 3.1 3.2 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_7 PF13176.6 AET40589.1 - 5.7 7.2 7.1 3.1 8.0 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat UPF0121 PF03661.13 AET40590.1 - 4.6e-24 85.1 10.1 1.2e-23 83.8 10.1 1.5 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0121) PAP2_C PF14360.6 AET40590.1 - 7.2 7.2 10.5 0.98 10.0 4.6 2.4 2 0 0 2 2 2 0 PAP2 superfamily C-terminal HSP70 PF00012.20 AET40591.1 - 3.3e-262 871.0 7.4 3.7e-262 870.9 7.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AET40591.1 - 8.9e-18 64.2 0.0 1.7e-16 60.0 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 AET40591.1 - 0.0031 17.2 0.0 0.0082 15.9 0.0 1.7 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 AET40591.1 - 0.021 14.1 1.7 0.022 14.0 0.1 1.9 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase BcrAD_BadFG PF01869.20 AET40591.1 - 0.05 13.1 0.0 7.4 6.0 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family DDE_Tnp_ISL3 PF01610.17 AET40591.1 - 0.71 9.5 4.6 0.97 9.1 0.7 2.2 2 0 0 2 2 2 0 Transposase PMBR PF09373.10 AET40591.1 - 1 9.7 0.0 1 9.7 0.0 2.4 3 0 0 3 3 3 0 Pseudomurein-binding repeat COX6A PF02046.15 AET40592.1 - 1e-37 129.0 0.6 1.1e-37 129.0 0.6 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa WD40 PF00400.32 AET40593.1 - 3.2e-14 53.1 3.7 0.0022 18.8 0.1 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat Eapp_C PF10238.9 AET40593.1 - 0.048 13.7 2.8 0.096 12.8 2.8 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein TFIIA PF03153.13 AET40593.1 - 1.8 8.5 19.9 2.8 7.9 19.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 AET40593.1 - 3.4 6.4 6.9 4.9 5.8 6.9 1.1 1 0 0 1 1 1 0 Presenilin Ribosomal_S26e PF01283.19 AET40594.1 - 1.8e-51 173.1 10.3 2e-51 172.9 10.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e PLL PF18587.1 AET40594.1 - 0.1 12.7 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 PTX/LNS-Like (PLL) domain COX5B PF01215.19 AET40595.1 - 2.5e-62 208.3 0.0 2.9e-62 208.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb WSC PF01822.19 AET40597.1 - 1.3e-08 34.9 10.8 1.3e-08 34.9 10.8 3.2 3 1 0 3 3 2 1 WSC domain TMEM154 PF15102.6 AET40597.1 - 3.4e-06 27.0 0.3 3.4e-06 27.0 0.3 5.3 1 1 1 2 2 1 1 TMEM154 protein family SIT PF15330.6 AET40597.1 - 0.011 16.1 0.2 0.011 16.1 0.2 3.0 3 1 0 3 3 2 0 SHP2-interacting transmembrane adaptor protein, SIT Asp5 PF17000.5 AET40597.1 - 0.015 15.4 0.9 0.043 13.9 0.9 1.8 1 0 0 1 1 1 0 Accessory secretory protein Sec, Asp5 DUF4233 PF14017.6 AET40597.1 - 0.024 15.0 0.2 0.066 13.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4233) Peptidase_U32 PF01136.19 AET40597.1 - 0.025 13.7 1.8 0.065 12.4 1.8 1.6 1 0 0 1 1 1 0 Peptidase family U32 Toxin_38 PF14866.6 AET40597.1 - 0.058 13.7 1.0 0.11 12.8 1.0 1.3 1 0 0 1 1 1 0 Potassium channel toxin DUF4381 PF14316.6 AET40597.1 - 0.072 13.3 0.1 0.13 12.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) EphA2_TM PF14575.6 AET40597.1 - 0.076 13.9 0.0 0.41 11.6 0.0 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Vpu PF00558.19 AET40597.1 - 0.12 12.1 0.1 0.25 11.1 0.1 1.4 1 0 0 1 1 1 0 Vpu protein Baculo_11_kDa PF06143.11 AET40597.1 - 0.17 11.4 0.6 0.45 10.1 0.6 1.7 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF3328 PF11807.8 AET40597.1 - 1.2 8.8 0.0 1.2 8.8 0.0 2.9 3 1 0 3 3 2 0 Domain of unknown function (DUF3328) YajC PF02699.15 AET40597.1 - 6 6.8 6.0 1.8 8.5 1.0 2.2 2 0 0 2 2 2 0 Preprotein translocase subunit zf-C2H2 PF00096.26 AET40598.1 - 1.3e-06 28.5 19.6 0.0001 22.5 2.9 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_8 PF15909.5 AET40598.1 - 0.00012 22.3 3.6 0.00029 21.1 3.6 1.6 1 0 0 1 1 1 1 C2H2-type zinc ribbon TFIIA PF03153.13 AET40598.1 - 0.0016 18.5 4.4 0.0025 17.9 4.4 1.5 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit zf-C2H2_4 PF13894.6 AET40598.1 - 0.0039 17.9 2.1 0.0039 17.9 2.1 4.0 4 0 0 4 4 4 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AET40598.1 - 0.014 15.8 2.4 0.014 15.8 2.4 3.1 3 0 0 3 3 3 0 Zinc-finger double domain SUIM_assoc PF16619.5 AET40598.1 - 0.91 9.6 12.4 0.086 12.9 7.1 2.2 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Pex14_N PF04695.13 AET40598.1 - 3.2 8.4 14.8 0.43 11.2 10.2 1.9 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ANAPC_CDC26 PF10471.9 AET40598.1 - 8.6 7.3 16.2 4.7 8.1 12.9 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 zf-C2HE PF16278.5 AET40598.1 - 10 6.7 11.6 0.52 10.8 5.2 2.5 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger CLP1_P PF16575.5 AET40599.1 - 2.3e-22 79.7 0.6 4.7e-21 75.5 0.1 2.4 2 1 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop G-alpha PF00503.20 AET40599.1 - 0.021 14.0 0.0 0.039 13.1 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 AET40599.1 - 0.078 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA PF00004.29 AET40600.1 - 6.1e-93 308.2 0.0 2e-46 157.7 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AET40600.1 - 4.3e-20 71.2 0.4 9.1e-09 35.0 0.1 2.8 2 1 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 AET40600.1 - 4.1e-14 52.6 0.0 5.9e-07 29.4 0.0 2.9 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AET40600.1 - 7.2e-13 49.3 0.2 0.00014 22.3 0.0 3.8 2 2 0 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 AET40600.1 - 9.6e-11 42.1 0.0 0.00066 19.8 0.0 3.1 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 AET40600.1 - 1.9e-09 37.8 0.0 0.00018 21.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 AET40600.1 - 2.5e-09 37.5 0.1 0.085 13.1 0.0 5.2 2 2 3 5 5 5 2 AAA domain AAA_5 PF07728.14 AET40600.1 - 7e-09 35.8 0.6 0.0051 16.8 0.0 3.9 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) Vps4_C PF09336.10 AET40600.1 - 1.4e-08 34.6 0.5 0.00041 20.3 0.0 3.0 3 0 0 3 3 2 2 Vps4 C terminal oligomerisation domain TIP49 PF06068.13 AET40600.1 - 1.7e-08 34.0 0.0 0.00098 18.4 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_18 PF13238.6 AET40600.1 - 6e-08 33.3 0.0 0.0024 18.4 0.0 3.3 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 AET40600.1 - 2.1e-07 31.3 0.0 0.017 15.5 0.0 3.2 3 0 0 3 3 2 2 RNA helicase ABC_tran PF00005.27 AET40600.1 - 1.2e-06 29.1 0.1 0.041 14.4 0.0 3.2 3 0 0 3 3 2 2 ABC transporter AAA_14 PF13173.6 AET40600.1 - 1.4e-06 28.4 0.0 0.077 13.0 0.0 2.9 3 0 0 3 3 2 2 AAA domain Zeta_toxin PF06414.12 AET40600.1 - 7e-06 25.5 0.0 0.043 13.1 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin Mg_chelatase PF01078.21 AET40600.1 - 7.2e-06 25.5 0.3 0.066 12.6 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 AET40600.1 - 9e-06 25.7 0.0 0.052 13.5 0.0 2.5 2 0 0 2 2 2 2 Rad17 P-loop domain IstB_IS21 PF01695.17 AET40600.1 - 1.1e-05 25.2 0.0 0.1 12.3 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_28 PF13521.6 AET40600.1 - 2e-05 24.9 0.0 0.078 13.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.6 AET40600.1 - 2.9e-05 24.5 0.6 0.11 12.9 0.1 3.7 3 1 0 3 3 2 1 AAA domain Cytidylate_kin2 PF13189.6 AET40600.1 - 4.4e-05 23.7 0.0 0.006 16.7 0.0 2.5 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_3 PF07726.11 AET40600.1 - 4.8e-05 23.2 0.0 0.44 10.4 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 AET40600.1 - 0.00011 21.8 0.0 0.46 10.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region SKI PF01202.22 AET40600.1 - 0.00012 22.3 0.0 0.27 11.3 0.0 2.7 2 0 0 2 2 2 2 Shikimate kinase AAA_11 PF13086.6 AET40600.1 - 0.00047 20.0 3.6 0.93 9.2 0.0 3.3 3 0 0 3 3 3 2 AAA domain TsaE PF02367.17 AET40600.1 - 0.00059 19.8 0.0 1.7 8.6 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 AET40600.1 - 0.00071 18.8 0.1 1.3 8.1 0.0 2.4 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 AET40600.1 - 0.00074 19.1 0.1 3.5 7.2 0.0 4.1 4 0 0 4 4 4 0 AAA domain Sigma54_activat PF00158.26 AET40600.1 - 0.00087 19.0 0.0 0.22 11.2 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain Viral_helicase1 PF01443.18 AET40600.1 - 0.00088 19.1 0.0 1.3 8.7 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase NACHT PF05729.12 AET40600.1 - 0.0013 18.6 0.0 2 8.3 0.0 3.3 3 0 0 3 3 3 1 NACHT domain DUF815 PF05673.13 AET40600.1 - 0.0018 17.5 0.0 0.19 10.8 0.0 3.0 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NB-ARC PF00931.22 AET40600.1 - 0.0026 17.0 0.0 1.4 8.0 0.0 2.9 3 0 0 3 3 3 1 NB-ARC domain AAA_24 PF13479.6 AET40600.1 - 0.0032 17.2 0.3 1.5 8.5 0.0 3.0 3 0 0 3 3 3 1 AAA domain Sigma54_activ_2 PF14532.6 AET40600.1 - 0.0042 17.2 0.1 1.6 8.9 0.0 2.9 3 0 0 3 3 2 1 Sigma-54 interaction domain CPT PF07931.12 AET40600.1 - 0.006 16.5 0.0 0.21 11.4 0.0 2.4 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein Cytidylate_kin PF02224.18 AET40600.1 - 0.0069 16.1 0.1 1 9.1 0.0 2.8 2 0 0 2 2 2 1 Cytidylate kinase ATPase PF06745.13 AET40600.1 - 0.0085 15.5 0.1 2.6 7.3 0.0 3.2 3 0 0 3 3 3 1 KaiC SRPRB PF09439.10 AET40600.1 - 0.015 14.7 0.0 2 7.8 0.0 2.7 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit IPT PF01745.16 AET40600.1 - 0.023 14.1 1.6 23 4.3 0.1 3.2 3 0 0 3 3 3 0 Isopentenyl transferase ATPase_2 PF01637.18 AET40600.1 - 0.023 14.6 0.2 11 5.9 0.0 3.6 3 1 1 4 4 4 0 ATPase domain predominantly from Archaea PhoH PF02562.16 AET40600.1 - 0.029 13.8 0.2 4.6 6.6 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein Phage_Gp17 PF17549.2 AET40600.1 - 0.029 14.4 3.0 0.1 12.6 3.0 2.0 1 0 0 1 1 1 0 Gene Product 17 PduV-EutP PF10662.9 AET40600.1 - 0.037 13.8 0.0 8.3 6.1 0.0 3.1 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_19 PF13245.6 AET40600.1 - 0.079 13.3 0.0 16 5.9 0.1 2.7 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 AET40600.1 - 0.08 12.8 0.0 0.61 10.0 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase AFG1_ATPase PF03969.16 AET40600.1 - 0.089 11.7 0.1 19 4.0 0.0 3.0 3 0 0 3 3 3 0 AFG1-like ATPase Hydin_ADK PF17213.3 AET40600.1 - 0.098 12.9 4.4 1.4 9.2 0.0 3.3 4 0 0 4 4 3 0 Hydin Adenylate kinase-like domain ResIII PF04851.15 AET40600.1 - 0.1 12.6 0.1 17 5.4 0.0 3.2 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit TniB PF05621.11 AET40600.1 - 0.11 11.9 0.0 6.9 6.0 0.0 2.6 2 0 0 2 2 2 0 Bacterial TniB protein NTPase_1 PF03266.15 AET40600.1 - 0.31 10.9 3.5 16 5.3 0.0 3.6 4 0 0 4 4 3 0 NTPase AAA_23 PF13476.6 AET40600.1 - 0.7 10.4 0.0 0.7 10.4 0.0 3.8 3 1 1 4 4 2 0 AAA domain KH_1 PF00013.29 AET40602.1 - 1.4e-12 47.3 0.1 3.4e-05 23.6 0.1 4.9 5 0 0 5 5 5 3 KH domain Phlebovirus_G2 PF07245.11 AET40602.1 - 0.0057 15.2 0.0 0.0085 14.6 0.0 1.1 1 0 0 1 1 1 1 Phlebovirus glycoprotein G2 LMBR1 PF04791.16 AET40603.1 - 2.1 7.2 5.7 2.7 6.8 5.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein ChaC PF04752.12 AET40604.1 - 5.7e-52 176.4 0.0 6.5e-52 176.2 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein GDI PF00996.18 AET40605.1 - 2.5e-226 751.2 0.4 2.9e-226 751.0 0.4 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 AET40605.1 - 0.009 16.2 0.0 0.018 15.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain LSM PF01423.22 AET40606.1 - 2.3e-18 65.7 0.4 2.9e-18 65.3 0.4 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 AET40606.1 - 0.02 14.5 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 Hfq protein Phage_prot_Gp6 PF05133.14 AET40606.1 - 0.035 13.2 0.2 0.039 13.1 0.2 1.0 1 0 0 1 1 1 0 Phage portal protein, SPP1 Gp6-like Gemin7 PF11095.8 AET40606.1 - 0.046 13.6 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) DUF3080 PF11279.8 AET40606.1 - 0.063 12.5 0.0 0.077 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3080) zf-C2H2_10 PF16588.5 AET40607.1 - 1.3e-13 50.4 3.6 1.9e-13 49.8 3.6 1.3 1 0 0 1 1 1 1 C2H2 zinc-finger zf-C2HE PF16278.5 AET40607.1 - 0.15 12.5 0.3 0.36 11.3 0.0 1.7 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-CCHC_4 PF14392.6 AET40607.1 - 0.22 11.3 1.6 0.56 10.0 1.6 1.6 2 0 0 2 2 2 0 Zinc knuckle GHMP_kinases_N PF00288.26 AET40608.1 - 2.9e-19 69.1 0.6 5.8e-19 68.1 0.6 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 AET40608.1 - 3.6e-05 24.0 0.2 0.00022 21.5 0.1 2.4 2 1 1 3 3 3 1 GHMP kinases C terminal Mtc PF03820.17 AET40609.1 - 3.1e-126 420.7 0.8 3.4e-126 420.5 0.8 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier DUF1180 PF06679.12 AET40609.1 - 0.12 12.8 0.4 0.21 12.0 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) NLE PF08154.12 AET40610.1 - 6.4e-23 81.0 0.2 1.3e-22 80.1 0.2 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain WD40 PF00400.32 AET40610.1 - 1e-22 79.9 11.2 4e-07 30.6 0.1 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat Nup160 PF11715.8 AET40610.1 - 3.3e-07 29.3 2.6 0.0053 15.5 0.1 2.8 4 0 0 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 AET40610.1 - 0.0094 15.3 0.3 1.7 7.9 0.1 3.3 2 1 0 2 2 2 1 WD40-like domain ANAPC4_WD40 PF12894.7 AET40610.1 - 0.017 15.4 0.1 0.13 12.5 0.0 2.5 2 1 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain MFS_1 PF07690.16 AET40611.1 - 2e-27 96.1 40.2 2e-27 96.1 40.2 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Tubulin_3 PF14881.6 AET40612.1 - 1.1e-21 77.3 0.0 2.1e-21 76.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 AET40612.1 - 1.6e-12 47.7 0.0 2.8e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 AET40612.1 - 0.093 12.9 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Tubulin/FtsZ family, GTPase domain DUF5054 PF16477.5 AET40612.1 - 0.13 12.0 0.1 0.2 11.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5054) IPPT PF01715.17 AET40613.1 - 5.4e-66 222.7 0.5 8.3e-66 222.1 0.5 1.2 1 0 0 1 1 1 1 IPP transferase IPT PF01745.16 AET40613.1 - 1.4e-05 24.6 0.1 0.00063 19.2 0.0 2.9 3 0 0 3 3 3 1 Isopentenyl transferase AAA_33 PF13671.6 AET40613.1 - 6.1e-05 23.2 0.0 0.0016 18.6 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 AET40613.1 - 0.00031 21.3 0.2 0.0044 17.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 AET40613.1 - 0.00065 19.0 0.0 0.0014 18.0 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin RsgA_GTPase PF03193.16 AET40613.1 - 0.0072 16.2 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase Cytidylate_kin PF02224.18 AET40613.1 - 0.038 13.7 0.0 0.072 12.8 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase Hpr_kinase_C PF07475.12 AET40613.1 - 0.042 13.4 0.0 0.12 11.9 0.0 1.7 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain DnaB_C PF03796.15 AET40613.1 - 0.066 12.5 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain RNA_helicase PF00910.22 AET40613.1 - 0.084 13.3 0.0 0.21 12.0 0.0 1.8 1 1 0 1 1 1 0 RNA helicase AAA_28 PF13521.6 AET40613.1 - 0.1 12.8 0.0 0.29 11.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AET40613.1 - 0.13 12.5 0.0 2.4 8.4 0.1 2.4 1 1 1 2 2 2 0 AAA domain AAA_16 PF13191.6 AET40613.1 - 0.14 12.5 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 AET40613.1 - 0.16 12.5 0.4 0.52 10.8 0.1 2.1 2 1 0 2 2 2 0 ABC transporter BRO1 PF03097.18 AET40614.1 - 1.1e-86 291.2 4.5 1.1e-86 291.2 4.5 1.6 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 AET40614.1 - 3.6e-30 105.3 17.0 6.3e-28 97.9 17.0 2.5 1 1 0 1 1 1 1 ALIX V-shaped domain binding to HIV Fib_alpha PF08702.10 AET40614.1 - 1.8 8.8 20.1 6.2 7.0 2.0 3.7 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family YgaB PF14182.6 AET40614.1 - 2.2 8.7 8.9 0.32 11.4 1.5 2.9 2 0 0 2 2 2 0 YgaB-like protein RecG_N PF17190.4 AET40614.1 - 6.6 7.5 18.7 7.4 7.4 1.6 5.1 3 1 1 4 4 4 0 RecG N-terminal helical domain DUF1664 PF07889.12 AET40614.1 - 7.4 6.6 10.1 10 6.2 4.3 3.4 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) Auxin_repressed PF05564.12 AET40615.1 - 0.11 13.2 1.4 0.28 11.9 1.4 1.6 1 0 0 1 1 1 0 Dormancy/auxin associated protein RIH_assoc PF08454.11 AET40615.1 - 9.7 6.1 8.0 62 3.5 1.0 4.2 3 2 0 3 3 3 0 RyR and IP3R Homology associated Myb_DNA-binding PF00249.31 AET40616.1 - 1.7e-22 79.4 2.5 9.7e-12 44.9 0.6 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AET40616.1 - 1.2e-18 67.0 3.6 2.9e-12 46.6 2.7 2.7 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_Cef PF11831.8 AET40616.1 - 2.2e-05 24.2 0.7 2.2e-05 24.2 0.7 3.4 3 1 0 3 3 3 1 pre-mRNA splicing factor component Rap1_C PF11626.8 AET40616.1 - 0.0012 18.9 0.3 0.0042 17.1 0.0 2.2 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain SLIDE PF09111.10 AET40616.1 - 0.039 14.0 0.9 2.3 8.3 0.0 3.7 2 1 1 3 3 3 0 SLIDE CAF20 PF17052.5 AET40617.1 - 2.8e-44 151.1 1.7 6.1e-44 150.0 1.7 1.5 1 1 0 1 1 1 1 Cap associated factor RRP7 PF12923.7 AET40617.1 - 0.0044 17.2 0.9 0.82 9.8 0.2 2.1 1 1 1 2 2 2 2 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DUF2383 PF09537.10 AET40617.1 - 0.071 13.5 0.1 0.11 12.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) DnaJ PF00226.31 AET40618.1 - 4.7e-27 93.9 0.5 7.5e-27 93.2 0.5 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 AET40618.1 - 4.6e-25 88.5 0.1 5.9e-25 88.1 0.1 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 AET40618.1 - 3.7e-14 52.8 21.3 7.3e-14 51.9 21.3 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 AET40618.1 - 0.0014 18.5 12.6 0.05 13.6 2.9 2.4 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein GP38 PF05268.11 AET40618.1 - 0.14 11.8 7.5 0.22 11.1 7.5 1.3 1 0 0 1 1 1 0 Phage tail fibre adhesin Gp38 Cytochrome_CBB3 PF13442.6 AET40618.1 - 0.27 11.6 0.1 0.27 11.6 0.1 2.5 1 1 2 3 3 3 0 Cytochrome C oxidase, cbb3-type, subunit III HypA PF01155.19 AET40618.1 - 0.4 10.7 12.0 3.2 7.8 0.9 2.2 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_10 PF16685.5 AET40618.1 - 2.2 8.5 7.7 0.12 12.5 2.1 1.7 2 0 0 2 2 2 0 zinc RING finger of MSL2 TackOD1 PF18551.1 AET40618.1 - 4.4 6.9 9.1 0.79 9.4 2.5 2.1 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 Glyco_hydro_72 PF03198.14 AET40620.1 - 5.4e-126 420.1 1.2 5.5e-125 416.8 0.6 2.0 2 0 0 2 2 2 1 Glucanosyltransferase Glyco_hydro_2_C PF02836.17 AET40620.1 - 8.6e-08 31.6 0.0 1.6e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Cellulase PF00150.18 AET40620.1 - 7.9e-06 25.5 0.1 0.00011 21.7 0.1 2.2 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Pkinase PF00069.25 AET40621.1 - 1.3e-40 139.4 0.3 1.4e-18 67.2 0.0 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 AET40621.1 - 1.6e-09 37.5 1.1 0.0079 15.5 0.3 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase NOA36 PF06524.12 AET40621.1 - 8.7 5.6 11.0 0.42 9.9 4.8 1.8 2 0 0 2 2 2 0 NOA36 protein RRM_1 PF00076.22 AET40622.1 - 7.9e-10 38.4 0.0 1.4e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 AET40622.1 - 1.4e-08 34.6 0.0 2.7e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif PsaN PF05479.11 AET40622.1 - 0.1 12.8 0.1 0.15 12.2 0.1 1.2 1 0 0 1 1 1 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) GMP_synt_C PF00958.22 AET40623.1 - 5.7e-45 151.3 0.0 1.3e-44 150.1 0.0 1.7 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 AET40623.1 - 1.5e-41 142.2 0.0 2.7e-41 141.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 AET40623.1 - 6.1e-08 32.1 0.0 1.3e-05 24.5 0.1 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 AET40623.1 - 5.7e-06 26.2 0.1 9.2e-05 22.3 0.1 2.4 1 1 0 1 1 1 1 Peptidase C26 PAPS_reduct PF01507.19 AET40623.1 - 0.0034 17.4 0.0 0.0058 16.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family QueC PF06508.13 AET40623.1 - 0.004 16.7 0.0 0.1 12.1 0.0 2.1 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 AET40623.1 - 0.0055 15.5 0.1 0.013 14.3 0.1 1.6 2 0 0 2 2 2 1 tRNA methyl transferase Arginosuc_synth PF00764.19 AET40623.1 - 0.0081 15.5 0.1 0.014 14.7 0.1 1.3 1 0 0 1 1 1 1 Arginosuccinate synthase ThiI PF02568.14 AET40623.1 - 0.041 13.5 0.0 0.1 12.2 0.0 1.7 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) HEM4 PF02602.15 AET40624.1 - 3e-45 154.4 0.0 3.4e-45 154.2 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD MAF_flag10 PF01973.18 AET40624.1 - 0.029 14.1 0.4 0.26 11.0 0.0 2.4 2 2 1 3 3 3 0 Protein of unknown function DUF115 TRAPPC10 PF12584.8 AET40625.1 - 9.5e-12 44.9 0.0 2.1e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Foie-gras_1 PF11817.8 AET40625.1 - 0.0081 15.8 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Foie gras liver health family 1 GRDP-like PF07173.12 AET40626.1 - 0.036 14.7 0.2 0.036 14.7 0.2 3.5 4 1 1 5 5 5 0 Glycine-rich domain-containing protein-like GHMP_kinases_N PF00288.26 AET40627.1 - 2e-15 56.7 0.3 4.8e-15 55.6 0.3 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 AET40627.1 - 0.0098 16.2 0.0 0.02 15.3 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal FSH1 PF03959.13 AET40629.1 - 9.5e-66 221.5 0.0 1.1e-65 221.3 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 AET40629.1 - 0.0016 18.3 0.0 0.0055 16.5 0.0 1.8 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 AET40629.1 - 0.022 14.0 0.0 0.082 12.2 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 UCH PF00443.29 AET40630.1 - 3.6e-52 177.4 5.6 4.5e-52 177.1 5.6 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AET40630.1 - 5.6e-19 68.9 10.9 5.6e-19 68.9 10.9 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 AET40630.1 - 4.9e-11 42.8 11.1 4.9e-11 42.8 11.1 4.2 3 1 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein DUF4874 PF16173.5 AET40630.1 - 0.23 11.2 0.5 0.67 9.6 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4874) Phosducin PF02114.16 AET40631.1 - 1.7e-12 46.9 7.9 4.2e-11 42.3 7.9 2.0 1 1 0 1 1 1 1 Phosducin Mre11_DNA_bind PF04152.14 AET40632.1 - 8.2e-44 149.9 0.1 2.1e-43 148.6 0.1 1.7 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 AET40632.1 - 7.1e-13 49.5 0.5 1.4e-12 48.6 0.5 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase His_Phos_1 PF00300.22 AET40633.1 - 1e-37 129.7 0.0 1.2e-37 129.6 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Rhodanese PF00581.20 AET40634.1 - 2e-14 54.0 0.0 6.3e-14 52.4 0.0 1.8 1 1 1 2 2 2 1 Rhodanese-like domain Phage_Mu_Gp45 PF06890.12 AET40634.1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage Mu Gp45 protein Rhodanese PF00581.20 AET40635.1 - 7.1e-11 42.6 0.0 8.6e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain RRP36 PF06102.12 AET40636.1 - 9.8e-38 129.7 26.0 9.8e-38 129.7 26.0 2.3 2 1 0 2 2 2 1 rRNA biogenesis protein RRP36 MRP_L53 PF10780.9 AET40637.1 - 1.6e-19 69.8 1.3 2.2e-19 69.4 1.3 1.2 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 Thioredoxin PF00085.20 AET40638.1 - 1.8e-23 82.5 0.1 4.2e-22 78.1 0.1 2.2 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 AET40638.1 - 1.2e-06 29.0 0.1 2.5e-06 27.9 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 AET40638.1 - 8.3e-05 22.1 0.0 0.00014 21.3 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 AET40638.1 - 0.0004 20.5 0.1 0.00098 19.3 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin-like TraF PF13728.6 AET40638.1 - 0.011 15.6 0.1 0.019 14.8 0.1 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_6 PF13848.6 AET40638.1 - 0.011 15.6 0.1 2.1 8.2 0.0 3.2 2 2 1 3 3 3 0 Thioredoxin-like domain Thioredoxin_8 PF13905.6 AET40638.1 - 0.032 14.5 0.0 0.8 10.1 0.0 2.5 1 1 1 2 2 2 0 Thioredoxin-like Thioredoxin_3 PF13192.6 AET40638.1 - 0.15 12.1 0.1 0.33 11.0 0.1 1.5 1 0 0 1 1 1 0 Thioredoxin domain DUF5641 PF18701.1 AET40638.1 - 0.62 10.3 2.4 54 4.0 0.0 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5641) AMMECR1 PF01871.17 AET40639.1 - 1.1e-36 125.9 0.0 1.5e-36 125.5 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 SNF2_N PF00176.23 AET40640.1 - 5.3e-70 235.9 0.4 1.5e-69 234.4 0.4 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AET40640.1 - 1.4e-21 76.9 0.8 4.8e-19 68.7 0.0 3.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain SnAC PF14619.6 AET40640.1 - 3.8e-14 53.0 0.9 3.8e-14 53.0 0.9 3.4 3 0 0 3 3 3 1 Snf2-ATP coupling, chromatin remodelling complex Bromodomain PF00439.25 AET40640.1 - 7.3e-12 45.2 0.5 2.7e-11 43.4 0.5 2.0 1 0 0 1 1 1 1 Bromodomain QLQ PF08880.11 AET40640.1 - 2.1e-10 40.2 2.5 2.1e-10 40.2 2.5 2.8 2 0 0 2 2 2 1 QLQ ResIII PF04851.15 AET40640.1 - 1.2e-07 31.9 3.0 2.2e-07 31.0 0.0 3.0 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HSA PF07529.13 AET40640.1 - 1.5e-06 28.4 8.8 1.5e-06 28.4 8.8 3.6 3 0 0 3 3 3 1 HSA SUIM_assoc PF16619.5 AET40640.1 - 0.0012 18.8 6.4 0.0012 18.8 6.4 3.5 2 1 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 AAA_22 PF13401.6 AET40640.1 - 0.53 10.6 7.3 15 5.8 0.0 4.1 4 0 0 4 4 4 0 AAA domain Tau95_N PF17682.1 AET40640.1 - 0.66 10.2 4.1 11 6.3 0.0 3.5 4 0 0 4 4 4 0 Tau95 Triple barrel domain TAFII55_N PF04658.13 AET40641.1 - 9e-50 168.5 0.1 9e-50 168.5 0.1 3.0 3 1 0 3 3 3 1 TAFII55 protein conserved region Cupredoxin_1 PF13473.6 AET40641.1 - 0.17 12.0 2.4 0.96 9.6 0.4 2.5 2 0 0 2 2 2 0 Cupredoxin-like domain RrnaAD PF00398.20 AET40642.1 - 7.1e-44 149.9 0.0 8.4e-44 149.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase S1 PF00575.23 AET40644.1 - 1.8e-58 194.8 18.3 5.2e-12 45.9 0.6 12.3 10 2 1 11 11 11 10 S1 RNA binding domain Suf PF05843.14 AET40644.1 - 1.3e-05 25.4 8.1 0.00013 22.1 2.3 2.9 1 1 0 2 2 2 2 Suppressor of forked protein (Suf) TPR_19 PF14559.6 AET40644.1 - 5.2e-05 23.7 0.0 0.54 10.8 0.0 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 AET40644.1 - 0.00038 20.4 2.9 0.14 12.2 0.3 2.7 2 0 0 2 2 2 2 Mad3/BUB1 homology region 1 TPR_14 PF13428.6 AET40644.1 - 0.013 16.2 0.0 6.4 7.9 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_15 PF13429.6 AET40644.1 - 0.25 10.5 1.5 9.4 5.3 0.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat PSD4 PF07631.11 AET40644.1 - 0.26 11.9 1.2 0.6 10.7 1.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1592) RNA_pol_Rbc25 PF08292.12 AET40644.1 - 1.5 9.1 7.4 2.7 8.3 0.0 4.9 6 0 0 6 6 6 0 RNA polymerase III subunit Rpc25 P5-ATPase PF12409.8 AET40645.1 - 1.1e-35 122.4 4.4 1.7e-35 121.8 1.7 2.4 2 0 0 2 2 2 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.20 AET40645.1 - 1.6e-28 99.4 0.1 3.7e-28 98.3 0.1 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 AET40645.1 - 1.6e-14 54.7 0.0 1.8e-07 31.7 0.0 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AET40645.1 - 1.1e-05 25.4 0.0 2.3e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 AET40645.1 - 0.016 14.8 0.0 0.045 13.5 0.0 1.8 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 AET40645.1 - 0.063 13.0 0.1 2.4 7.8 0.0 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Mpv17_PMP22 PF04117.12 AET40646.1 - 1e-18 67.3 0.7 3.6e-18 65.5 0.7 2.0 1 0 0 1 1 1 1 Mpv17 / PMP22 family Tetraspanin PF00335.20 AET40646.1 - 0.011 15.5 0.1 0.017 14.9 0.1 1.2 1 0 0 1 1 1 0 Tetraspanin family S10_plectin PF03501.15 AET40647.1 - 3e-41 139.4 0.1 3.4e-41 139.2 0.1 1.0 1 0 0 1 1 1 1 Plectin/S10 domain DUF4364 PF14277.6 AET40647.1 - 0.02 14.7 0.1 0.028 14.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) HTH_45 PF14947.6 AET40647.1 - 0.081 12.9 0.3 0.13 12.2 0.3 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix Septin PF00735.18 AET40648.1 - 3.8e-94 315.1 0.1 5.8e-94 314.5 0.1 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 AET40648.1 - 1.6e-06 28.2 0.0 3.9e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 AET40648.1 - 0.00027 20.3 0.1 0.00071 19.0 0.1 1.7 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 AET40648.1 - 0.0004 20.3 0.5 0.0013 18.7 0.1 2.0 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 AET40648.1 - 0.00079 19.5 2.1 0.13 12.3 0.1 3.0 2 1 1 3 3 3 1 Dynamin family FtsK_SpoIIIE PF01580.18 AET40648.1 - 0.037 13.4 0.0 0.068 12.5 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_16 PF13191.6 AET40648.1 - 0.06 13.7 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 AET40648.1 - 0.062 12.8 0.1 0.12 11.8 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region T2SSE PF00437.20 AET40648.1 - 0.075 12.1 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_24 PF13479.6 AET40648.1 - 0.092 12.5 0.4 0.26 11.0 0.0 1.9 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.6 AET40648.1 - 0.13 12.5 0.0 0.32 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 AET40648.1 - 0.14 12.3 0.1 3.4 7.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 AET40648.1 - 0.16 12.1 1.2 1.1 9.3 0.1 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain GTP_EFTU PF00009.27 AET40648.1 - 0.17 11.4 1.4 6.8 6.2 0.4 2.9 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain TsaE PF02367.17 AET40648.1 - 0.32 11.0 1.3 1.3 9.1 0.1 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PIN_4 PF13638.6 AET40649.1 - 0.069 13.4 0.0 0.15 12.3 0.0 1.7 1 1 0 1 1 1 0 PIN domain FA_hydroxylase PF04116.13 AET40650.1 - 3.9e-26 92.0 20.1 3.9e-26 92.0 20.1 1.9 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily GATase_5 PF13507.6 AET40651.1 - 2.3e-98 328.5 0.0 3.3e-98 327.9 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 AET40651.1 - 1.1e-45 155.5 0.0 2.7e-31 108.8 0.0 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 AET40651.1 - 9.4e-27 93.3 0.0 1.7e-26 92.5 0.0 1.4 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 AET40651.1 - 1.5e-21 76.6 0.0 4.3e-21 75.2 0.0 1.9 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain DUF2462 PF09495.10 AET40652.1 - 4.7e-13 49.7 9.9 4.7e-13 49.7 9.9 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2462) 60KD_IMP PF02096.20 AET40653.1 - 2.6e-08 33.9 7.2 4.3e-08 33.2 1.9 2.1 2 0 0 2 2 2 2 60Kd inner membrane protein PDZ_3 PF17815.1 AET40653.1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 PDZ domain Spt4 PF06093.13 AET40654.1 - 1.7e-28 98.5 0.5 2e-28 98.3 0.5 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger zf-TFIIB PF13453.6 AET40654.1 - 0.07 12.5 0.9 0.14 11.5 0.9 1.5 1 0 0 1 1 1 0 Transcription factor zinc-finger MRP-L27 PF09809.9 AET40655.1 - 2.4e-32 111.1 0.4 3.4e-32 110.6 0.4 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 WD40 PF00400.32 AET40656.1 - 1.3e-14 54.3 0.0 0.00056 20.7 0.0 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET40656.1 - 1.8e-10 41.0 0.0 0.038 14.3 0.0 5.1 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain RCC1_2 PF13540.6 AET40657.1 - 1.4e-19 69.3 10.6 8.1e-08 31.9 0.3 6.3 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 AET40657.1 - 1.7e-15 57.3 2.5 1.4e-05 25.6 0.0 6.6 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.7 AET40657.1 - 0.00013 21.8 0.1 0.00026 20.8 0.1 1.5 1 0 0 1 1 1 1 F-box-like Esterase PF00756.20 AET40658.1 - 1e-54 185.8 0.0 1.2e-54 185.7 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Paf1 PF03985.13 AET40659.1 - 5.7e-96 322.1 13.5 6.3e-96 321.9 13.5 1.0 1 0 0 1 1 1 1 Paf1 MPM1 PF17234.2 AET40660.1 - 8e-55 185.7 3.6 1.3e-54 185.1 3.6 1.3 1 0 0 1 1 1 1 Mitochondrial peculiar membrane protein 1 CBFD_NFYB_HMF PF00808.23 AET40661.1 - 5.4e-06 26.6 0.1 9.9e-06 25.8 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF5479 PF17575.2 AET40661.1 - 0.076 13.6 0.0 0.13 12.8 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5479) DSPc PF00782.20 AET40662.1 - 1.7e-27 95.8 0.5 2.9e-21 75.7 0.2 3.6 3 0 0 3 3 3 3 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AET40662.1 - 9.6e-06 25.3 0.1 0.0012 18.4 0.1 2.4 2 0 0 2 2 2 2 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 AET40662.1 - 0.032 14.3 0.2 0.94 9.6 0.1 2.3 2 0 0 2 2 2 0 Inositol hexakisphosphate YhfH PF14149.6 AET40662.1 - 2.1 8.4 5.4 0.26 11.3 0.6 2.0 2 0 0 2 2 2 0 YhfH-like protein PALP PF00291.25 AET40663.1 - 7e-65 219.3 0.0 8.6e-65 219.0 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Mrpl_C PF18502.1 AET40664.1 - 2.6e-35 121.1 1.4 3.1e-35 120.8 0.3 1.7 2 1 0 2 2 2 1 54S ribosomal protein L8 C-terminal domain Ribosomal_L17 PF01196.19 AET40664.1 - 1.9e-27 96.0 0.1 3.8e-27 95.0 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L17 Gag_p10 PF02337.17 AET40664.1 - 0.13 12.2 0.0 0.84 9.6 0.0 2.2 2 0 0 2 2 2 0 Retroviral GAG p10 protein adh_short PF00106.25 AET40666.1 - 1.6e-23 83.2 0.0 3.4e-23 82.1 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 AET40666.1 - 3.3e-16 59.7 0.0 4.5e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 AET40666.1 - 1.8e-09 37.5 0.0 3.1e-09 36.7 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 AET40666.1 - 2.1e-06 27.1 0.0 3.2e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 AET40666.1 - 0.00026 20.5 0.0 0.0018 17.8 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PMT_4TMC PF16192.5 AET40666.1 - 0.017 14.7 0.2 0.029 14.0 0.2 1.4 1 0 0 1 1 1 0 C-terminal four TMM region of protein-O-mannosyltransferase Shikimate_DH PF01488.20 AET40666.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase zf-C2H2_2 PF12756.7 AET40667.1 - 5.2e-35 119.8 4.2 5e-33 113.5 2.3 2.5 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) LAS2 PF15792.5 AET40667.1 - 0.0084 16.6 0.3 0.018 15.5 0.3 1.5 1 0 0 1 1 1 1 Lung adenoma susceptibility protein 2 zf-C2H2 PF00096.26 AET40667.1 - 0.16 12.5 0.2 0.16 12.5 0.2 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type PGC7_Stella PF15549.6 AET40667.1 - 0.31 11.0 3.0 0.92 9.5 0.2 2.3 2 0 0 2 2 2 0 PGC7/Stella/Dppa3 domain Phosphodiest PF01663.22 AET40668.1 - 1.4e-12 47.9 2.8 8.1e-09 35.5 0.4 2.1 1 1 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 AET40668.1 - 0.0013 18.2 0.1 0.0023 17.4 0.1 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 AET40668.1 - 0.091 12.1 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 Sulfatase Vpu PF00558.19 AET40668.1 - 0.89 9.4 3.5 23 4.8 0.0 3.0 3 0 0 3 3 3 0 Vpu protein Ribosomal_L37 PF08561.10 AET40669.1 - 8e-22 78.0 5.8 2.5e-16 60.3 0.2 2.1 1 1 1 2 2 2 2 Mitochondrial ribosomal protein L37 Nup88 PF10168.9 AET40670.1 - 2.2e-06 25.8 3.2 5.2e-06 24.6 0.0 2.2 2 0 0 2 2 2 1 Nuclear pore component Nup54 PF13874.6 AET40670.1 - 0.036 14.2 1.5 0.077 13.1 1.5 1.5 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 DUF1674 PF07896.12 AET40671.1 - 7.4e-20 71.2 1.2 1.3e-19 70.4 1.2 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) JHY PF15261.6 AET40671.1 - 0.053 14.2 0.0 0.069 13.9 0.0 1.2 1 0 0 1 1 1 0 Jhy protein Aminotran_1_2 PF00155.21 AET40672.1 - 2.3e-56 191.5 0.0 2.6e-56 191.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AET40672.1 - 0.0021 17.1 0.0 0.015 14.2 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 AET40672.1 - 0.0043 15.6 0.0 0.014 14.0 0.0 1.7 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Alliinase_C PF04864.13 AET40672.1 - 0.037 12.9 0.0 0.063 12.1 0.0 1.3 1 0 0 1 1 1 0 Allinase HbrB PF08539.11 AET40673.1 - 1.9e-26 93.1 1.6 7.4e-25 87.9 0.2 3.1 2 1 0 2 2 2 1 HbrB-like DED PF01335.21 AET40673.1 - 0.015 15.6 0.0 0.071 13.4 0.0 2.1 2 0 0 2 2 2 0 Death effector domain Fumerase_C PF05683.12 AET40673.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Fumarase C-terminus Pkinase PF00069.25 AET40674.1 - 2.8e-30 105.6 0.0 3.4e-29 102.0 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40674.1 - 1.1e-18 67.4 0.0 2.3e-17 63.2 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AET40674.1 - 0.0012 17.7 0.0 0.0016 17.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 AET40674.1 - 0.039 13.6 0.0 2.9 7.5 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 zf-C2H2 PF00096.26 AET40675.1 - 1.5e-24 85.0 59.9 8e-06 26.0 3.0 9.5 9 0 0 9 9 8 7 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AET40675.1 - 3.7e-24 84.0 48.3 1.6e-08 34.6 0.7 7.6 8 0 0 8 8 7 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 AET40675.1 - 1.4e-18 66.0 62.1 4.2e-05 24.0 1.9 9.6 9 0 0 9 9 8 6 C2H2-type zinc finger Zap1_zf2 PF18217.1 AET40675.1 - 5.1e-12 45.6 4.2 5.1e-12 45.6 4.2 4.7 4 0 0 4 4 4 1 Zap1 zinc finger 2 zf-C2H2_jaz PF12171.8 AET40675.1 - 1.1e-07 31.9 41.6 0.00013 22.1 0.4 7.1 9 0 0 9 9 8 4 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 AET40675.1 - 1.7e-07 31.7 30.3 0.0056 17.3 3.2 6.5 4 2 2 6 6 6 4 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 AET40675.1 - 2.8e-07 30.4 29.5 0.032 14.3 0.5 6.4 5 1 1 6 6 6 3 C2H2-type zinc finger zf-met PF12874.7 AET40675.1 - 2.2e-06 27.9 32.5 0.027 14.8 0.6 6.9 7 0 0 7 7 6 4 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 AET40675.1 - 5.9e-06 26.5 34.6 0.0059 16.9 2.3 6.0 3 1 3 6 6 6 4 C2H2-type zinc ribbon zf-C2HC_2 PF13913.6 AET40675.1 - 2.6e-05 24.0 18.5 0.77 9.7 0.3 5.5 4 0 0 4 4 4 3 zinc-finger of a C2HC-type zf-H2C2_5 PF13909.6 AET40675.1 - 0.00015 21.4 8.1 0.0018 18.0 1.1 7.8 8 0 0 8 8 6 4 C2H2-type zinc-finger domain zf-Di19 PF05605.12 AET40675.1 - 0.00043 20.5 8.1 0.0011 19.2 1.3 6.3 3 3 2 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.10 AET40675.1 - 1.5 9.0 23.4 0.33 11.1 0.7 5.2 4 2 0 4 4 4 0 Zinc ribbon domain zf-CHCC PF10276.9 AET40675.1 - 3.1 7.9 9.3 24 5.1 0.0 4.0 4 0 0 4 4 4 0 Zinc-finger domain DUF2225 PF09986.9 AET40675.1 - 3.9 7.1 14.7 0.47 10.1 1.3 3.3 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-C2H2_9 PF16293.5 AET40675.1 - 6.4 6.7 18.3 0.74 9.7 1.2 5.2 6 1 1 7 7 7 0 C2H2 type zinc-finger (1 copy) Lysine_decarbox PF03641.14 AET40676.1 - 1.3e-43 148.2 0.1 2.6e-43 147.3 0.1 1.5 1 1 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 AET40676.1 - 1.7e-10 40.7 0.3 3e-10 39.9 0.3 1.5 1 1 0 1 1 1 1 SLOG cluster4 family Myb_DNA-binding PF00249.31 AET40678.1 - 2.8e-23 81.8 2.5 5.2e-14 52.2 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AET40678.1 - 5.3e-19 68.2 4.8 7e-15 55.0 0.1 2.6 2 1 1 3 3 3 2 Myb-like DNA-binding domain SLIDE PF09111.10 AET40678.1 - 0.0039 17.2 0.0 0.016 15.2 0.0 2.0 2 0 0 2 2 2 1 SLIDE Myb_DNA-bind_7 PF15963.5 AET40678.1 - 0.012 15.4 0.1 0.32 10.9 0.0 2.2 1 1 1 2 2 2 0 Myb DNA-binding like Tim54 PF11711.8 AET40679.1 - 6.3e-129 430.0 1.6 7.4e-129 429.8 1.6 1.0 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 BNIP3 PF06553.12 AET40679.1 - 0.1 12.3 1.9 0.16 11.6 1.1 1.7 2 0 0 2 2 2 0 BNIP3 Vps26 PF03643.15 AET40680.1 - 4.6e-112 373.5 1.2 5.3e-112 373.3 1.2 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 AET40680.1 - 0.0021 18.1 0.6 0.08 13.0 0.3 2.8 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Imm19 PF15563.6 AET40680.1 - 0.023 14.2 0.2 0.033 13.7 0.2 1.2 1 0 0 1 1 1 0 Immunity protein 19 DUF1947 PF09183.10 AET40680.1 - 0.084 13.2 0.1 0.34 11.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1947) Pkinase PF00069.25 AET40681.1 - 1.7e-38 132.5 0.0 2.7e-38 131.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40681.1 - 1.6e-21 76.7 0.0 2.1e-21 76.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 AET40681.1 - 2e-09 37.3 0.1 3.1e-09 36.7 0.1 1.2 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 AET40681.1 - 0.00031 20.1 0.0 0.00059 19.2 0.0 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 AET40681.1 - 0.024 14.5 0.1 0.051 13.5 0.1 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family rRNA_proc-arch PF13234.6 AET40683.1 - 1.3e-80 271.2 0.9 2.8e-80 270.1 0.9 1.6 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 AET40683.1 - 1.4e-53 180.9 0.7 2.8e-53 180.0 0.7 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 AET40683.1 - 3.4e-18 66.0 0.0 3.8e-17 62.6 0.0 2.6 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET40683.1 - 1.4e-06 28.6 0.0 1.3e-05 25.5 0.0 2.5 1 1 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 AET40683.1 - 0.083 13.2 0.0 0.39 11.0 0.0 2.2 1 0 0 1 1 1 0 AAA domain Peptidase_M24_C PF16188.5 AET40683.1 - 0.23 11.6 1.1 0.77 9.9 1.1 1.9 1 1 0 1 1 1 0 C-terminal region of peptidase_M24 HSM3_N PF18795.1 AET40684.1 - 3.8e-64 216.4 20.5 3.8e-64 216.4 20.5 1.6 2 0 0 2 2 2 1 DNA mismatch repair protein HSM3, N terminal domain HSM3_C PF18794.1 AET40684.1 - 1.2e-58 197.6 9.3 1.6e-58 197.2 2.9 2.3 2 0 0 2 2 2 2 DNA mismatch repair protein HSM3, C terminal domain Snf7 PF03357.21 AET40685.1 - 8.4e-16 58.0 11.3 1.3e-15 57.4 11.3 1.2 1 0 0 1 1 1 1 Snf7 Tox-SHH PF15652.6 AET40685.1 - 0.48 11.4 2.0 44 5.1 0.4 3.2 3 0 0 3 3 3 0 HNH/Endo VII superfamily toxin with a SHH signature Allexi_40kDa PF05549.11 AET40685.1 - 5.7 6.4 10.5 1.8 8.0 0.7 2.4 1 1 1 2 2 2 0 Allexivirus 40kDa protein UBX PF00789.20 AET40686.1 - 9.8e-17 60.9 0.0 1.8e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 UBX domain DUF682 PF05081.12 AET40686.1 - 0.00053 19.7 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF682) Pkinase PF00069.25 AET40687.1 - 2.8e-60 203.9 0.0 4e-60 203.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40687.1 - 2e-35 122.3 0.0 2.8e-35 121.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET40687.1 - 2.6e-06 27.0 0.0 4.5e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 AET40687.1 - 2.5e-05 23.2 0.0 9.1e-05 21.4 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 AET40687.1 - 0.012 14.9 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 AET40687.1 - 0.016 14.2 0.1 0.03 13.3 0.1 1.4 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 AET40687.1 - 0.026 14.1 0.1 0.043 13.4 0.1 1.4 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.11 AET40687.1 - 0.054 12.6 0.0 0.093 11.8 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Choline_kinase PF01633.20 AET40687.1 - 0.12 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Ras PF00071.22 AET40688.1 - 1.1e-41 142.2 0.4 7.3e-41 139.5 0.4 1.9 1 1 0 1 1 1 1 Ras family Roc PF08477.13 AET40688.1 - 3.3e-32 111.2 0.3 4.8e-32 110.7 0.3 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET40688.1 - 6.9e-18 64.7 1.6 9.8e-17 60.9 1.6 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AET40688.1 - 2.3e-08 34.1 0.1 3.4e-08 33.6 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 AET40688.1 - 4.2e-07 29.6 0.0 6e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AET40688.1 - 2e-05 24.3 0.0 0.00014 21.5 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain TniB PF05621.11 AET40688.1 - 0.0014 18.1 0.0 0.0028 17.1 0.0 1.6 1 1 0 1 1 1 1 Bacterial TniB protein RsgA_GTPase PF03193.16 AET40688.1 - 0.0018 18.2 1.5 0.3 11.0 0.2 2.4 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 AET40688.1 - 0.0028 17.1 0.2 0.0068 15.9 0.2 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 AET40688.1 - 0.0083 15.3 0.5 1.1 8.4 0.3 2.2 1 1 1 2 2 2 2 G-protein alpha subunit AAA_16 PF13191.6 AET40688.1 - 0.012 16.0 0.0 0.019 15.3 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain MnmE_helical PF12631.7 AET40688.1 - 0.037 14.2 0.1 0.053 13.7 0.1 1.2 1 0 0 1 1 1 0 MnmE helical domain SHMT PF00464.19 AET40689.1 - 1.2e-200 666.2 0.0 1.4e-200 666.0 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase NAT PF04768.13 AET40690.1 - 1.4e-46 158.3 0.1 4.1e-46 156.7 0.0 1.7 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Sld5 PF05916.11 AET40691.1 - 1.8e-19 70.2 0.2 3e-19 69.5 0.2 1.4 1 0 0 1 1 1 1 GINS complex protein Drf_FH1 PF06346.12 AET40693.1 - 0.0018 18.1 8.5 0.39 10.4 0.0 4.8 2 1 1 3 3 3 2 Formin Homology Region 1 EI24 PF07264.11 AET40694.1 - 0.0011 19.3 17.1 0.0029 17.9 17.1 1.7 1 1 1 2 2 2 1 Etoposide-induced protein 2.4 (EI24) Sigma70_ner PF04546.13 AET40694.1 - 0.018 15.0 2.7 0.027 14.3 2.7 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region FAM176 PF14851.6 AET40694.1 - 0.025 14.2 0.7 0.025 14.2 0.7 1.7 2 0 0 2 2 2 0 FAM176 family DUF4611 PF15387.6 AET40694.1 - 0.079 13.2 6.7 0.14 12.4 6.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Myc_N PF01056.18 AET40694.1 - 0.91 9.4 5.3 1.2 8.9 5.3 1.1 1 0 0 1 1 1 0 Myc amino-terminal region NOA36 PF06524.12 AET40694.1 - 2.7 7.3 14.3 3.7 6.8 14.3 1.1 1 0 0 1 1 1 0 NOA36 protein RXT2_N PF08595.11 AET40694.1 - 2.7 8.0 6.3 4.2 7.4 6.3 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF2457 PF10446.9 AET40694.1 - 3.2 6.8 16.3 4.3 6.4 16.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PBP1_TM PF14812.6 AET40694.1 - 7.2 7.1 11.5 13 6.2 11.5 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4199 PF13858.6 AET40694.1 - 7.8 6.9 12.7 36 4.7 7.2 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF4199) CDC45 PF02724.14 AET40694.1 - 9 4.5 9.6 12 4.0 9.6 1.1 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.10 AET40694.1 - 9.6 6.7 22.9 21 5.6 22.9 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Peptidase_M28 PF04389.17 AET40695.1 - 1.3e-37 129.4 0.1 1.9e-37 128.9 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 AET40695.1 - 2.8e-08 33.6 0.0 6.5e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 AET40695.1 - 0.00022 21.0 0.0 0.00037 20.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 AET40695.1 - 0.013 14.5 0.0 0.02 13.9 0.0 1.4 1 0 0 1 1 1 0 M42 glutamyl aminopeptidase DnaJ PF00226.31 AET40696.1 - 4e-19 68.5 4.7 1.4e-18 66.8 4.7 2.0 1 0 0 1 1 1 1 DnaJ domain TFIIA PF03153.13 AET40696.1 - 0.019 15.0 16.3 0.032 14.3 16.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peroxin-13_N PF04088.13 AET40696.1 - 0.22 11.8 3.7 0.69 10.2 3.7 1.8 1 0 0 1 1 1 0 Peroxin 13, N-terminal region CNOT1_HEAT PF16418.5 AET40696.1 - 0.26 11.4 9.1 0.18 11.9 6.5 2.0 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 1 HEAT repeat DUF4834 PF16118.5 AET40696.1 - 4.2 8.4 10.0 15 6.6 10.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Aminotran_1_2 PF00155.21 AET40697.1 - 2.6e-62 211.1 0.0 3.1e-62 210.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AET40697.1 - 0.0032 16.5 0.0 0.022 13.7 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 AET40697.1 - 0.0038 15.8 0.0 0.011 14.3 0.0 1.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_3 PF00202.21 AET40697.1 - 0.11 11.1 0.0 0.18 10.4 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-III SMC_N PF02463.19 AET40698.1 - 9.1e-57 192.0 31.5 1.8e-56 191.0 31.5 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 AET40698.1 - 1.1e-28 99.8 0.1 1.2e-27 96.6 0.0 2.8 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 AET40698.1 - 3.1e-15 56.8 6.9 8.5e-09 35.6 0.4 3.1 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 AET40698.1 - 0.0024 17.6 99.2 0.014 15.1 42.1 4.7 2 2 1 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 AET40698.1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SAD_SRA PF02182.17 AET40698.1 - 0.26 11.0 4.5 0.46 10.2 0.0 3.2 3 0 0 3 3 3 0 SAD/SRA domain DUF1192 PF06698.11 AET40698.1 - 0.82 9.8 10.7 9 6.4 0.1 5.4 3 1 1 4 4 4 0 Protein of unknown function (DUF1192) BRCT PF00533.26 AET40698.1 - 1.1 9.7 8.9 74 3.8 0.0 5.9 7 0 0 7 7 7 0 BRCA1 C Terminus (BRCT) domain AAA_23 PF13476.6 AET40698.1 - 4 7.9 129.6 0.023 15.2 55.1 7.1 2 2 3 5 5 5 0 AAA domain Cytokin_check_N PF10407.9 AET40699.1 - 1.4e-33 114.7 2.7 3.1e-33 113.5 2.7 1.6 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus Csm1_N PF18504.1 AET40699.1 - 1.4 9.3 8.7 0.16 12.3 0.4 3.5 3 0 0 3 3 3 0 Csm1 N-terminal domain CAP PF00188.26 AET40701.1 - 8.8e-19 68.6 1.0 1.9e-18 67.5 1.0 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family CAP PF00188.26 AET40702.1 - 1.5e-20 74.3 9.7 3.5e-20 73.1 9.7 1.6 1 1 0 1 1 1 1 Cysteine-rich secretory protein family KH_1 PF00013.29 AET40703.1 - 2.4e-74 245.1 31.0 3.5e-12 46.0 0.4 12.4 12 0 0 12 12 12 8 KH domain KH_2 PF07650.17 AET40703.1 - 5.3e-08 32.6 19.4 0.0048 16.7 0.3 6.6 5 1 1 6 6 6 4 KH domain KH_4 PF13083.6 AET40703.1 - 0.00011 21.9 4.8 0.56 10.1 0.0 5.9 6 0 0 6 6 6 1 KH domain SLS PF14611.6 AET40703.1 - 0.0016 18.3 16.4 0.067 13.0 0.2 6.6 6 3 1 7 7 7 2 Mitochondrial inner-membrane-bound regulator MOEP19 PF16005.5 AET40703.1 - 0.021 14.8 0.0 0.6 10.1 0.0 3.3 3 0 0 3 3 3 0 KH-like RNA-binding domain DUF4974 PF16344.5 AET40703.1 - 0.52 10.3 2.4 21 5.2 0.0 4.4 5 0 0 5 5 5 0 Domain of unknown function (DUF4974) KH_5 PF13184.6 AET40703.1 - 0.87 9.7 14.5 1.5 9.0 0.0 6.9 8 0 0 8 8 8 0 NusA-like KH domain Ras PF00071.22 AET40704.1 - 4.6e-54 182.4 0.3 5.4e-54 182.2 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET40704.1 - 1.5e-36 125.3 0.1 2e-36 124.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET40704.1 - 1.5e-15 57.1 0.1 1.9e-15 56.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AET40704.1 - 8.1e-07 28.6 0.1 1.1e-06 28.2 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AET40704.1 - 4.1e-06 26.9 0.0 6.6e-06 26.2 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AET40704.1 - 0.00044 20.2 0.6 0.88 9.5 0.1 2.6 1 1 2 3 3 3 2 RsgA GTPase GTP_EFTU PF00009.27 AET40704.1 - 0.00067 19.3 0.1 0.0012 18.5 0.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain TniB PF05621.11 AET40704.1 - 0.026 13.9 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_16 PF13191.6 AET40704.1 - 0.026 14.9 0.0 0.041 14.3 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Mitofilin PF09731.9 AET40705.1 - 1.4e-41 143.1 29.5 1.4e-32 113.4 28.1 2.1 1 1 0 2 2 2 2 Mitochondrial inner membrane protein DUF365 PF04033.12 AET40705.1 - 1.9 8.8 5.3 37 4.7 4.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF365) Actin PF00022.19 AET40706.1 - 1.2e-95 320.5 0.0 9.2e-95 317.6 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 AET40706.1 - 0.12 11.2 0.0 1.4 7.6 0.0 2.0 2 0 0 2 2 2 0 MreB/Mbl protein IBR PF01485.21 AET40707.1 - 1.4e-16 60.4 45.3 1.3e-09 38.2 12.4 4.3 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 AET40707.1 - 0.00013 21.8 13.8 0.00013 21.8 13.8 4.7 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AET40707.1 - 0.017 15.4 10.9 0.017 15.4 10.9 5.1 2 1 2 4 4 4 0 Ring finger domain zf-C3HC4_2 PF13923.6 AET40707.1 - 0.019 14.8 6.9 0.019 14.8 6.9 4.8 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) DUF3808 PF10300.9 AET40708.1 - 4.2e-115 385.2 0.0 5e-115 385.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) DUF4692 PF15763.5 AET40708.1 - 0.1 13.1 0.2 0.19 12.2 0.2 1.3 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) EF-hand_4 PF12763.7 AET40709.1 - 8.7e-06 25.6 0.1 2.5e-05 24.2 0.1 1.8 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Vps51 PF08700.11 AET40710.1 - 1.2e-11 44.5 5.8 5.4e-11 42.4 1.3 2.1 2 0 0 2 2 2 2 Vps51/Vps67 CEND1 PF15677.5 AET40710.1 - 0.12 12.9 2.1 0.15 12.6 2.1 1.1 1 0 0 1 1 1 0 Cell cycle exit and neuronal differentiation protein 1 Hep_59 PF07052.11 AET40710.1 - 0.18 12.6 3.3 0.26 12.1 3.3 1.2 1 0 0 1 1 1 0 Hepatocellular carcinoma-associated antigen 59 Arrestin_C PF02752.22 AET40711.1 - 4.6e-16 59.5 0.1 2.3e-14 54.0 0.0 2.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 AET40711.1 - 4.9e-07 29.9 0.0 3.5e-05 23.9 0.1 2.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Exo70 PF03081.15 AET40712.1 - 3e-79 266.8 2.8 3e-79 266.8 2.8 2.4 3 0 0 3 3 3 2 Exo70 exocyst complex subunit phiKZ_IP PF12699.7 AET40712.1 - 0.01 15.0 5.8 0.45 9.6 0.1 3.5 4 0 0 4 4 4 0 phiKZ-like phage internal head proteins DUF573 PF04504.14 AET40712.1 - 0.053 14.2 0.3 0.28 11.8 0.3 2.4 1 0 0 1 1 1 0 Protein of unknown function, DUF573 DUF5344 PF17279.2 AET40712.1 - 0.16 12.6 3.4 3.1 8.4 0.0 4.0 3 1 1 4 4 4 0 Family of unknown function (DUF5344) Laminin_II PF06009.12 AET40712.1 - 8.8 6.3 9.3 15 5.6 3.5 3.0 2 1 1 3 3 3 0 Laminin Domain II RNA_lig_T4_1 PF09511.10 AET40713.1 - 7.8e-80 267.8 0.2 7.8e-80 267.8 0.2 2.1 3 0 0 3 3 3 1 RNA ligase tRNA_lig_kinase PF08303.11 AET40713.1 - 4.2e-71 238.4 1.1 8.2e-71 237.5 1.1 1.5 1 0 0 1 1 1 1 tRNA ligase kinase domain tRNA_lig_CPD PF08302.11 AET40713.1 - 1.1e-52 179.0 0.0 1.8e-52 178.3 0.0 1.3 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain ABC_tran PF00005.27 AET40713.1 - 0.0035 17.9 0.0 0.0086 16.6 0.0 1.6 1 0 0 1 1 1 1 ABC transporter PRK PF00485.18 AET40713.1 - 0.0063 16.3 0.2 0.02 14.6 0.0 1.9 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 AET40713.1 - 0.015 15.9 0.2 0.065 13.8 0.2 2.2 1 1 0 1 1 1 0 AAA domain CPT PF07931.12 AET40713.1 - 0.015 15.1 0.0 0.044 13.6 0.0 1.7 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_5 PF07728.14 AET40713.1 - 0.16 12.0 0.1 2.6 8.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Vta1_C PF18097.1 AET40713.1 - 7.2 6.4 5.8 2.2 8.1 0.1 2.8 3 0 0 3 3 3 0 Vta1 C-terminal domain OTCace PF00185.24 AET40714.1 - 4.4e-48 163.3 1.3 6.4e-48 162.8 1.3 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 AET40714.1 - 3.1e-41 140.9 0.2 1.8e-40 138.4 0.0 2.0 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Zn_clus PF00172.18 AET40716.1 - 6.1e-10 39.1 11.9 1e-09 38.4 11.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BRCT PF00533.26 AET40717.1 - 3.2e-15 56.2 0.3 0.0052 17.1 0.0 4.4 4 0 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 AET40717.1 - 9.3e-11 41.5 1.3 0.0002 21.2 0.0 4.2 4 0 0 4 4 4 2 twin BRCT domain BRCT_2 PF16589.5 AET40717.1 - 2.7e-08 34.1 0.1 0.00033 21.0 0.0 3.4 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 AET40717.1 - 0.019 15.1 0.0 0.053 13.6 0.0 1.7 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain GWT1 PF06423.12 AET40718.1 - 3.1e-40 137.7 4.6 3.1e-40 137.7 4.6 2.5 2 1 0 2 2 2 1 GWT1 DUF4818 PF16089.5 AET40718.1 - 0.023 15.1 0.0 0.023 15.1 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4818) UvrD-helicase PF00580.21 AET40719.1 - 1.4e-61 208.8 0.0 1.4e-61 208.8 0.0 3.1 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 AET40719.1 - 4.6e-44 151.2 0.0 3.9e-43 148.2 0.0 2.7 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 AET40719.1 - 9.1e-27 94.2 0.0 2e-26 93.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 AET40719.1 - 1.2e-08 34.6 0.1 0.0006 19.6 0.0 2.5 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 AET40719.1 - 0.0012 18.6 0.0 0.049 13.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 AET40719.1 - 0.031 13.9 0.7 0.39 10.3 0.0 2.8 3 0 0 3 3 3 0 AAA domain Arif-1 PF06770.11 AET40719.1 - 0.08 12.6 0.2 0.15 11.8 0.2 1.3 1 0 0 1 1 1 0 Actin-rearrangement-inducing factor (Arif-1) Helicase_RecD PF05127.14 AET40719.1 - 0.13 12.1 0.0 0.34 10.7 0.0 1.7 1 0 0 1 1 1 0 Helicase PBP1_TM PF14812.6 AET40719.1 - 8.2 6.9 8.2 0.69 10.3 2.3 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pkinase PF00069.25 AET40720.1 - 6.9e-66 222.3 0.0 1.2e-65 221.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40720.1 - 9.5e-44 149.6 0.0 1.8e-43 148.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET40720.1 - 2.8e-09 36.7 0.0 5.6e-06 25.9 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 AET40720.1 - 0.0027 16.5 1.1 0.0042 15.9 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 AET40720.1 - 0.011 15.6 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ribosomal_L21p PF00829.21 AET40721.1 - 3.7e-12 46.4 0.1 4.4e-12 46.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein PTPLA PF04387.14 AET40722.1 - 1.3e-46 158.4 8.6 1.3e-46 158.4 8.6 1.4 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA SAPS PF04499.15 AET40723.1 - 3.8e-184 613.0 0.1 3.8e-184 613.0 0.1 2.9 3 0 0 3 3 3 1 SIT4 phosphatase-associated protein ChAPs PF09295.10 AET40724.1 - 3.4e-53 181.1 0.8 2.3e-43 148.7 0.1 2.1 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_2 PF07719.17 AET40724.1 - 5.7e-07 29.2 6.3 0.0028 17.7 0.7 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 AET40724.1 - 6.5e-07 29.1 2.6 0.005 16.9 0.4 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 AET40724.1 - 6.9e-06 26.5 0.6 2.9e-05 24.5 0.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AET40724.1 - 1.1e-05 25.6 0.8 0.00015 21.9 0.1 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 AET40724.1 - 5.3e-05 22.8 5.5 0.00025 20.7 0.9 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 AET40724.1 - 0.00019 22.0 0.0 0.00046 20.8 0.0 1.6 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_9 PF13371.6 AET40724.1 - 0.00049 20.2 0.2 0.0041 17.2 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 AET40724.1 - 0.0036 17.6 0.5 0.0036 17.6 0.5 2.2 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 AET40724.1 - 0.04 14.2 3.1 0.066 13.5 0.9 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 AET40724.1 - 0.048 14.3 0.2 0.16 12.6 0.2 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 AET40724.1 - 0.15 11.8 3.7 0.61 9.8 0.3 2.9 2 1 1 3 3 3 0 TPR repeat TPR_7 PF13176.6 AET40724.1 - 0.48 10.6 4.1 3.9 7.7 0.4 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat PI3_PI4_kinase PF00454.27 AET40725.1 - 5.8e-56 190.1 0.0 8.3e-56 189.6 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase GCS PF03074.16 AET40726.1 - 6.9e-139 463.3 0.0 9e-139 462.9 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase GTP_EFTU PF00009.27 AET40727.1 - 6e-59 198.9 0.1 1.1e-58 198.0 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 AET40727.1 - 1.6e-28 98.6 0.0 1.9e-27 95.1 0.0 2.4 2 0 0 2 2 2 1 Elongation Factor G, domain II EFG_C PF00679.24 AET40727.1 - 9.2e-15 54.5 0.0 8.3e-07 29.0 0.0 2.6 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 AET40727.1 - 6.6e-09 36.0 0.2 1.9e-08 34.6 0.1 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RF3_C PF16658.5 AET40727.1 - 1.5e-05 24.8 0.0 3.1e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 AET40727.1 - 0.014 15.5 0.1 0.036 14.1 0.1 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase NTS_2 PF15448.6 AET40727.1 - 0.017 15.5 0.0 0.046 14.1 0.0 1.8 1 0 0 1 1 1 0 N-terminal segments of P. falciparum erythrocyte membrane protein IF-2B PF01008.17 AET40728.1 - 1.9e-70 237.3 0.0 2.2e-70 237.1 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family Sin_N PF04801.13 AET40729.1 - 2.6e-18 66.5 1.6 5.7e-18 65.4 1.6 1.5 1 1 0 1 1 1 1 Sin-like protein conserved region DEAD PF00270.29 AET40730.1 - 4.6e-38 130.7 0.0 7.6e-38 130.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET40730.1 - 1.4e-18 67.3 0.0 3.1e-18 66.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 AET40730.1 - 2.5e-18 66.0 0.1 6.9e-18 64.6 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 AET40730.1 - 0.00022 21.3 0.0 0.00061 19.8 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Zn_clus PF00172.18 AET40731.1 - 5.2e-07 29.7 10.7 9.6e-07 28.8 10.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 AET40731.1 - 5.2e-05 23.2 0.0 0.00012 22.0 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 AET40731.1 - 0.15 12.3 0.0 0.5 10.6 0.0 1.9 1 0 0 1 1 1 0 PAS domain zf-C2HC5 PF06221.13 AET40732.1 - 3.6e-21 74.9 10.0 6.1e-21 74.2 10.0 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type MqsA_antitoxin PF15731.5 AET40732.1 - 0.19 11.8 2.0 0.75 9.9 0.2 2.6 2 0 0 2 2 2 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA Apis_Csd PF11671.8 AET40732.1 - 4 7.5 9.8 11 6.0 4.2 2.8 3 0 0 3 3 3 0 Complementary sex determiner protein Pam16 PF03656.13 AET40733.1 - 1.1e-44 151.5 0.6 1.2e-44 151.4 0.6 1.0 1 0 0 1 1 1 1 Pam16 SET PF00856.28 AET40734.1 - 7.8e-10 39.4 0.1 3e-09 37.5 0.0 2.2 2 1 0 2 2 2 1 SET domain PHD PF00628.29 AET40734.1 - 1.9e-09 37.2 10.0 4.7e-09 36.0 10.0 1.7 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 AET40734.1 - 0.0006 19.3 4.2 0.0014 18.2 4.2 1.6 1 0 0 1 1 1 1 PHD-finger zf-CW PF07496.15 AET40734.1 - 0.37 10.9 2.4 1 9.4 2.4 1.8 1 0 0 1 1 1 0 CW-type Zinc Finger Pkinase PF00069.25 AET40735.1 - 3e-51 174.3 0.1 2.4e-49 168.1 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AET40735.1 - 1.3e-26 93.4 0.4 7.1e-26 91.0 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 AET40735.1 - 0.0024 17.3 0.2 0.004 16.5 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DNA_pol_phi PF04931.13 AET40735.1 - 0.24 9.5 17.1 0.51 8.4 17.1 1.5 1 0 0 1 1 1 0 DNA polymerase phi PPP4R2 PF09184.11 AET40735.1 - 0.28 10.7 43.9 0.036 13.7 24.9 2.3 2 0 0 2 2 2 0 PPP4R2 RRN3 PF05327.11 AET40735.1 - 9 4.7 9.3 18 3.7 9.3 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 ThrE PF06738.12 AET40736.1 - 8.4e-71 238.1 16.6 6.2e-64 215.7 4.8 2.3 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 AET40736.1 - 9.7e-14 51.6 9.4 9.7e-14 51.6 9.4 2.3 2 0 0 2 2 2 2 Threonine/Serine exporter, ThrE Ribosomal_60s PF00428.19 AET40736.1 - 2.9 8.6 12.5 0.051 14.2 4.7 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein BP28CT PF08146.12 AET40737.1 - 1.1e-38 132.6 5.4 3.2e-38 131.1 4.1 2.7 2 0 0 2 2 2 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 AET40737.1 - 3.7e-20 72.4 3.2 3.7e-20 72.4 3.2 4.8 5 0 0 5 5 5 1 U3 small nucleolar RNA-associated protein 10 HEAT PF02985.22 AET40737.1 - 0.0057 16.8 0.1 8.8 6.9 0.0 4.3 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.6 AET40737.1 - 0.085 13.3 0.1 19 5.7 0.0 3.8 3 0 0 3 3 3 0 HEAT repeats ACDC PF14733.6 AET40737.1 - 9.1 6.7 11.3 3.7 7.9 0.1 5.2 3 1 1 4 4 4 0 AP2-coincident C-terminal UNC-50 PF05216.13 AET40738.1 - 8.2e-85 283.9 21.0 9.4e-85 283.7 21.0 1.0 1 0 0 1 1 1 1 UNC-50 family PLDc PF00614.22 AET40740.1 - 1.7e-17 62.8 1.9 2.2e-08 33.9 0.3 3.8 3 0 0 3 3 3 2 Phospholipase D Active site motif PLDc_2 PF13091.6 AET40740.1 - 9e-12 45.0 1.7 1e-07 31.9 0.1 4.0 3 1 0 3 3 3 2 PLD-like domain PX PF00787.24 AET40740.1 - 3e-06 27.2 3.0 0.021 14.8 0.2 3.6 3 0 0 3 3 3 2 PX domain DUF3316 PF11777.8 AET40740.1 - 0.071 13.2 0.1 0.58 10.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3316) GATA PF00320.27 AET40741.1 - 3.3e-15 55.4 3.4 6.2e-15 54.5 3.4 1.5 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 AET40741.1 - 0.0043 16.5 0.3 0.0089 15.5 0.3 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Snf7 PF03357.21 AET40742.1 - 2e-10 40.5 19.5 2e-10 40.5 19.5 1.4 1 1 0 1 1 1 1 Snf7 BORCS7 PF16088.5 AET40742.1 - 0.012 15.9 0.8 0.012 15.9 0.8 2.4 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 7 DUF948 PF06103.11 AET40742.1 - 0.22 11.8 11.4 0.31 11.3 1.1 3.3 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DMSP_lyase PF16867.5 AET40742.1 - 0.37 10.4 0.1 0.37 10.4 0.1 2.1 3 0 0 3 3 3 0 Dimethlysulfonioproprionate lyase ECH_2 PF16113.5 AET40742.1 - 0.58 9.6 9.6 0.29 10.6 7.5 1.5 1 1 0 1 1 1 0 Enoyl-CoA hydratase/isomerase APG6_N PF17675.1 AET40742.1 - 1.9 9.0 18.2 1.5 9.3 3.1 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region H-kinase_dim PF02895.14 AET40742.1 - 3.5 8.1 14.2 0.31 11.5 0.5 3.4 3 2 0 3 3 3 0 Signal transducing histidine kinase, homodimeric domain CHDCT2 PF08074.11 AET40742.1 - 5 7.3 9.2 0.68 10.1 3.1 2.2 1 1 1 2 2 2 0 CHDCT2 (NUC038) domain Cpn60_TCP1 PF00118.24 AET40743.1 - 4.4e-159 530.2 4.2 5e-159 530.0 4.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pyr_redox_2 PF07992.14 AET40743.1 - 0.019 14.2 0.3 0.25 10.5 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Dak2 PF02734.17 AET40743.1 - 0.075 12.9 0.7 1.1 9.1 0.0 2.7 2 1 0 2 2 2 0 DAK2 domain ADH_zinc_N PF00107.26 AET40744.1 - 4.2e-09 36.5 0.0 6.7e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 AET40744.1 - 2.3e-05 24.2 0.1 0.00012 21.9 0.1 1.9 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 AET40744.1 - 0.00053 21.0 0.0 0.0028 18.7 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase PIR PF00399.19 AET40745.1 - 3.6e-07 29.6 8.3 1.2e-06 28.0 8.3 1.9 1 0 0 1 1 1 1 Yeast PIR protein repeat FKBP_C PF00254.28 AET40747.1 - 5.5e-33 113.2 0.0 6.4e-33 112.9 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Eaf7 PF07904.13 AET40748.1 - 6.2e-33 113.4 0.1 6.2e-33 113.4 0.1 2.6 3 0 0 3 3 3 1 Chromatin modification-related protein EAF7 TFIIF_alpha PF05793.12 AET40748.1 - 0.072 11.7 28.9 0.099 11.2 28.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Merozoite_SPAM PF07133.11 AET40748.1 - 2.1 8.3 26.7 0.36 10.8 20.1 2.1 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) DAP PF15228.6 AET40748.1 - 5.8 8.2 10.4 1.2 10.3 6.5 1.9 2 0 0 2 2 2 0 Death-associated protein S4 PF01479.25 AET40749.1 - 9.5e-17 60.5 0.0 1.9e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 AET40749.1 - 0.00058 19.6 0.0 0.0014 18.4 0.0 1.6 1 0 0 1 1 1 1 S4 domain GN3L_Grn1 PF08701.11 AET40749.1 - 0.025 14.6 1.0 0.057 13.5 1.0 1.6 1 0 0 1 1 1 0 GNL3L/Grn1 putative GTPase TGT PF01702.18 AET40749.1 - 0.15 11.2 0.0 0.26 10.4 0.0 1.4 1 0 0 1 1 1 0 Queuine tRNA-ribosyltransferase CAP_N PF01213.19 AET40750.1 - 6.2e-108 361.0 0.3 6.2e-108 361.0 0.3 1.6 1 1 1 2 2 2 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 AET40750.1 - 1.3e-57 193.8 3.5 1.9e-57 193.3 3.5 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 AET40750.1 - 0.57 9.9 3.8 1.1 9.0 3.8 1.5 1 0 0 1 1 1 0 Tubulin binding cofactor C SF3b10 PF07189.11 AET40752.1 - 1.2e-28 99.1 1.0 1.3e-28 98.9 1.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) THOC2_N PF16134.5 AET40753.1 - 6.2e-147 490.9 7.3 6.2e-147 490.9 7.3 2.2 3 0 0 3 3 3 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 AET40753.1 - 1.3e-37 129.6 5.1 1.3e-37 129.6 5.1 3.8 3 1 0 3 3 3 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 AET40753.1 - 8.2e-19 67.5 0.1 2.9e-18 65.7 0.1 2.1 1 0 0 1 1 1 1 Transcription- and export-related complex subunit CHDCT2 PF08074.11 AET40753.1 - 0.8 9.9 8.7 5.8 7.1 0.0 3.1 3 0 0 3 3 3 0 CHDCT2 (NUC038) domain C2 PF00168.30 AET40754.1 - 3.4e-13 49.8 0.0 5.5e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 C2 domain RNA_pol_3_Rpc31 PF11705.8 AET40755.1 - 3.3e-49 168.2 9.8 4.7e-49 167.7 9.8 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 CNDH2_C PF16858.5 AET40755.1 - 0.1 12.5 3.4 0.12 12.2 3.4 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term PTPA PF03095.15 AET40755.1 - 0.18 11.2 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotyrosyl phosphate activator (PTPA) protein Cnd2 PF05786.14 AET40755.1 - 0.2 10.3 12.0 0.22 10.1 12.0 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 BUD22 PF09073.10 AET40755.1 - 4.3 6.6 10.2 4.9 6.4 10.2 1.1 1 0 0 1 1 1 0 BUD22 PGA2 PF07543.12 AET40756.1 - 2.6e-12 46.9 7.1 1.2e-09 38.3 7.1 2.0 1 1 0 1 1 1 1 Protein trafficking PGA2 DNA_primase_lrg PF04104.14 AET40756.1 - 0.11 11.9 1.3 0.24 10.7 1.2 1.6 1 1 1 2 2 2 0 Eukaryotic and archaeal DNA primase, large subunit LapA_dom PF06305.11 AET40756.1 - 1.1 9.2 3.3 5.1 7.0 0.1 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain CAP_GLY PF01302.25 AET40757.1 - 3.6e-18 65.3 1.1 7.7e-18 64.3 1.1 1.6 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 AET40757.1 - 8e-05 23.0 0.0 0.00013 22.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain LSM PF01423.22 AET40758.1 - 1.1e-19 69.9 0.6 1.4e-19 69.6 0.6 1.1 1 0 0 1 1 1 1 LSM domain UPRTase PF14681.6 AET40759.1 - 1.9e-75 252.9 0.0 2.4e-75 252.5 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 AET40759.1 - 0.0021 17.6 0.0 0.0029 17.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain CoA_binding_2 PF13380.6 AET40759.1 - 0.14 12.7 0.0 0.2 12.1 0.0 1.2 1 0 0 1 1 1 0 CoA binding domain Actin PF00022.19 AET40760.1 - 5e-120 400.8 0.0 2.3e-119 398.7 0.0 1.7 1 1 0 1 1 1 1 Actin DUF2009 PF09418.10 AET40761.1 - 2.4e-206 686.2 0.1 2.9e-206 685.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) zf-B_box PF00643.24 AET40761.1 - 0.00022 21.3 2.9 0.00042 20.4 2.9 1.5 1 0 0 1 1 1 1 B-box zinc finger CEBP_ZZ PF16366.5 AET40761.1 - 0.0027 17.9 3.2 0.0057 16.9 3.2 1.5 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain zf-C3HC4_3 PF13920.6 AET40761.1 - 0.75 9.7 5.4 1.4 8.9 5.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) IBR PF01485.21 AET40761.1 - 3.9 7.8 7.9 3.8 7.8 5.3 2.2 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain GAPT PF11770.8 AET40762.1 - 0.054 13.3 1.2 3.1 7.7 0.1 2.9 3 0 0 3 3 3 0 GRB2-binding adapter (GAPT) Pga1 PF10333.9 AET40764.1 - 1.4e-63 213.9 0.9 1.6e-63 213.7 0.9 1.0 1 0 0 1 1 1 1 GPI-Mannosyltransferase II co-activator Endosulfine PF04667.17 AET40765.1 - 5e-31 106.7 0.1 7.6e-31 106.1 0.1 1.3 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region INSIG PF07281.12 AET40766.1 - 2.5e-17 63.3 11.2 1e-15 58.0 7.5 3.0 1 1 1 2 2 2 2 Insulin-induced protein (INSIG) WLM PF08325.10 AET40767.1 - 1.3e-53 181.9 1.7 3.6e-53 180.5 1.7 1.7 1 1 0 1 1 1 1 WLM domain DUF45 PF01863.17 AET40767.1 - 0.032 14.3 0.0 0.064 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF45 zf-AN1 PF01428.16 AET40768.1 - 6.4e-10 39.0 11.9 9.9e-10 38.4 11.9 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger Prefoldin_2 PF01920.20 AET40770.1 - 1.9e-20 72.8 12.2 2.3e-20 72.5 12.2 1.1 1 0 0 1 1 1 1 Prefoldin subunit sCache_like PF16736.5 AET40770.1 - 0.05 13.7 3.3 0.088 12.9 3.2 1.5 1 1 0 1 1 1 0 Single Cache-like ABC_tran_CTD PF16326.5 AET40770.1 - 0.087 13.1 1.7 0.087 13.1 1.7 2.8 2 1 1 3 3 3 0 ABC transporter C-terminal domain Glucodextran_N PF09137.11 AET40770.1 - 0.17 11.4 0.4 0.24 10.9 0.3 1.3 1 1 0 1 1 1 0 Glucodextranase, domain N DUF16 PF01519.16 AET40770.1 - 0.49 10.9 8.5 1.2 9.7 8.5 1.7 1 1 0 1 1 1 0 Protein of unknown function DUF16 FTA4 PF13093.6 AET40770.1 - 2.3 8.1 9.7 1.7 8.5 3.5 2.0 1 1 1 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Rimk_N PF18030.1 AET40771.1 - 0.077 13.4 0.0 0.097 13.1 0.0 1.2 1 0 0 1 1 1 0 RimK PreATP-grasp domain Ammonium_transp PF00909.21 AET40772.1 - 1.1e-123 412.9 26.6 1.3e-123 412.7 26.6 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Far-17a_AIG1 PF04750.14 AET40773.1 - 7e-14 51.6 7.8 9.3e-14 51.2 7.8 1.1 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Pkinase PF00069.25 AET40774.1 - 6.6e-61 206.0 3.6 9.3e-42 143.2 0.2 2.6 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 AET40774.1 - 8.6e-27 94.0 2.0 2.2e-20 73.1 0.0 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase Haspin_kinase PF12330.8 AET40774.1 - 5.8e-05 22.2 0.1 5.8e-05 22.2 0.1 2.8 3 0 0 3 3 3 1 Haspin like kinase domain Kdo PF06293.14 AET40774.1 - 0.0017 17.7 0.9 0.0067 15.8 0.0 2.2 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AET40774.1 - 0.013 15.4 3.6 0.71 9.7 0.1 3.1 2 1 1 3 3 3 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 AET40774.1 - 0.049 12.7 0.0 0.078 12.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 AET40774.1 - 0.072 11.8 0.0 0.072 11.8 0.0 2.1 2 0 0 2 2 2 0 Fungal protein kinase DNA_pol_D_N PF18018.1 AET40774.1 - 0.079 13.1 0.9 0.24 11.5 0.1 2.1 1 1 1 2 2 2 0 DNA polymerase delta subunit OB-fold domain Ribosomal_L44 PF00935.19 AET40775.1 - 1.3e-34 118.4 13.0 2.1e-34 117.9 13.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 Chs7 PF12271.8 AET40776.1 - 1.3e-106 356.2 18.4 1.5e-106 356.0 18.4 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone SRTM1 PF15872.5 AET40776.1 - 0.19 11.9 2.4 0.49 10.6 0.5 2.4 2 0 0 2 2 2 0 Serine-rich and transmembrane domain-containing protein 1 Stevor PF17410.2 AET40776.1 - 1.3 8.5 3.3 1.1 8.8 0.1 2.0 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame TRAF6_Z2 PF18048.1 AET40777.1 - 0.00013 21.9 1.0 0.37 10.9 0.4 2.2 2 0 0 2 2 2 2 TNF receptor-associated factor 6 zinc finger 2 Lar_restr_allev PF14354.6 AET40777.1 - 0.027 14.8 0.4 0.032 14.6 0.4 1.2 1 0 0 1 1 1 0 Restriction alleviation protein Lar Ogr_Delta PF04606.12 AET40777.1 - 3 7.9 7.0 70 3.5 5.5 2.5 2 1 0 2 2 2 0 Ogr/Delta-like zinc finger GTP_EFTU PF00009.27 AET40778.1 - 4.5e-58 196.0 0.0 7.4e-58 195.3 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 AET40778.1 - 1.1e-15 57.4 0.2 7.2e-15 54.8 0.0 2.4 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 AET40778.1 - 2.1e-11 44.0 0.0 5.5e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 AET40778.1 - 1.4e-07 31.5 0.0 3.7e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 AET40778.1 - 0.0012 18.6 0.0 0.0075 16.0 0.0 2.3 2 0 0 2 2 2 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 AET40778.1 - 0.026 14.6 0.0 0.085 12.9 0.0 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase BORCS6 PF10157.9 AET40781.1 - 0.066 13.4 0.5 0.066 13.4 0.5 2.7 3 0 0 3 3 3 0 BLOC-1-related complex sub-unit 6 PDGLE PF13190.6 AET40781.1 - 0.48 10.3 1.9 3.8 7.5 0.0 2.8 2 1 0 2 2 2 0 PDGLE domain DNA_RNApol_7kD PF03604.13 AET40782.1 - 4.3e-17 61.5 1.7 5.7e-17 61.1 1.7 1.2 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit DZR PF12773.7 AET40782.1 - 0.0017 18.4 0.5 0.0023 17.9 0.5 1.3 1 0 0 1 1 1 1 Double zinc ribbon TFIIS_C PF01096.18 AET40782.1 - 0.0062 16.4 0.8 2.4 8.1 0.1 2.3 2 0 0 2 2 2 2 Transcription factor S-II (TFIIS) HypA PF01155.19 AET40782.1 - 0.008 16.2 0.2 0.008 16.2 0.2 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_10 PF10058.9 AET40782.1 - 0.01 15.5 0.4 0.31 10.8 0.0 2.1 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein zf_UBZ PF18439.1 AET40782.1 - 0.011 15.3 0.7 4.2 7.0 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger MCM_OB PF17207.3 AET40782.1 - 0.02 14.7 0.3 0.024 14.5 0.3 1.1 1 0 0 1 1 1 0 MCM OB domain Zn_ribbon_SprT PF17283.2 AET40782.1 - 0.032 14.1 2.4 0.048 13.6 2.1 1.5 1 1 0 1 1 1 0 SprT-like zinc ribbon domain zinc-ribbon_6 PF10005.9 AET40782.1 - 0.04 14.6 0.3 0.053 14.2 0.3 1.2 1 0 0 1 1 1 0 zinc-ribbon domain DUF2318 PF10080.9 AET40782.1 - 0.049 13.8 0.1 0.053 13.6 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) Ribosomal_L40e PF01020.17 AET40782.1 - 0.084 12.8 2.9 0.12 12.3 2.9 1.3 1 0 0 1 1 1 0 Ribosomal L40e family FYDLN_acid PF09538.10 AET40782.1 - 0.091 13.5 0.4 0.1 13.3 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF951 PF06107.11 AET40782.1 - 0.12 12.3 1.8 1.1 9.3 0.4 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF951) TF_Zn_Ribbon PF08271.12 AET40782.1 - 0.13 11.9 2.0 4.3 6.9 2.6 2.1 1 1 2 3 3 3 0 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 AET40782.1 - 0.2 11.8 3.0 0.78 9.9 2.9 1.9 1 1 2 3 3 3 0 Zinc ribbon domain Rubredoxin_2 PF18073.1 AET40782.1 - 0.27 11.0 3.5 3.3 7.5 0.6 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain zinc_ribbon_4 PF13717.6 AET40782.1 - 0.35 10.8 5.2 2.5 8.1 5.3 2.2 1 1 0 1 1 1 0 zinc-ribbon domain bZIP_1 PF00170.21 AET40783.1 - 1.2e-08 34.9 3.0 3.3e-08 33.5 3.0 1.7 1 0 0 1 1 1 1 bZIP transcription factor Aft1_OSA PF11785.8 AET40783.1 - 1.9e-06 28.2 1.5 4.1e-06 27.1 0.3 2.2 2 0 0 2 2 2 1 Aft1 osmotic stress response (OSM) domain bZIP_2 PF07716.15 AET40783.1 - 0.00027 20.9 6.1 0.00096 19.2 6.1 2.0 1 1 0 1 1 1 1 Basic region leucine zipper Aft1_HRA PF11786.8 AET40783.1 - 0.00035 20.9 14.7 0.00035 20.9 14.7 3.6 1 1 2 3 3 3 1 Aft1 HRA domain SR-25 PF10500.9 AET40783.1 - 2.1 7.9 21.0 0.036 13.7 10.5 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein dCMP_cyt_deam_1 PF00383.23 AET40784.1 - 4e-27 94.0 0.9 5.7e-27 93.5 0.9 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 AET40784.1 - 1.5e-14 53.9 0.0 2.3e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase PS_Dcarbxylase PF02666.15 AET40785.1 - 2e-71 239.7 0.0 8.7e-70 234.3 0.0 2.1 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase SAP18 PF06487.12 AET40785.1 - 0.17 12.1 0.0 0.38 10.9 0.0 1.6 1 0 0 1 1 1 0 Sin3 associated polypeptide p18 (SAP18) ANAPC1 PF12859.7 AET40786.1 - 1.1e-07 32.5 4.8 1.6e-06 28.7 4.8 2.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 1 AMPK1_CBM PF16561.5 AET40787.1 - 1.5e-09 37.9 0.1 8.5e-05 22.7 0.0 2.4 2 0 0 2 2 2 2 Glycogen recognition site of AMP-activated protein kinase RRM_1 PF00076.22 AET40788.1 - 2.7e-23 81.6 0.2 4e-15 55.4 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 AET40788.1 - 0.022 14.7 0.1 0.12 12.3 0.0 2.1 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Ribosomal_L22 PF00237.19 AET40790.1 - 2.6e-19 69.4 0.0 3.9e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e SHR3_chaperone PF08229.11 AET40791.1 - 3.1e-74 248.0 1.1 3.7e-74 247.8 1.1 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 Ribosomal_S3_C PF00189.20 AET40792.1 - 2.5e-23 82.4 0.1 1.3e-22 80.1 0.2 2.1 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 AET40792.1 - 7.4e-12 44.9 0.0 4e-11 42.6 0.1 2.2 2 0 0 2 2 2 1 KH domain Ras PF00071.22 AET40793.1 - 3.4e-45 153.6 0.0 4.7e-45 153.1 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET40793.1 - 3.4e-20 72.5 0.0 1.4e-19 70.5 0.0 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET40793.1 - 1e-06 28.3 0.0 2.4e-06 27.1 0.0 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 AET40793.1 - 0.0038 16.8 0.0 0.016 14.8 0.0 2.0 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 AET40793.1 - 0.052 13.6 0.0 0.095 12.8 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase adh_short PF00106.25 AET40794.1 - 1.9e-08 34.0 0.0 1.3e-07 31.3 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 AET40794.1 - 2e-07 30.8 0.0 4.7e-07 29.6 0.0 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AET40794.1 - 1.5e-05 25.0 0.0 2.4e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 KR domain ANAPC4_WD40 PF12894.7 AET40795.1 - 0.00032 20.9 0.0 0.015 15.6 0.0 2.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AET40795.1 - 0.013 14.8 0.2 0.61 9.4 0.0 2.6 2 0 0 2 2 2 0 WD40-like domain WD40 PF00400.32 AET40795.1 - 0.018 15.9 0.2 3 8.9 0.0 3.7 3 0 0 3 3 3 0 WD domain, G-beta repeat FTA4 PF13093.6 AET40795.1 - 0.15 11.9 0.7 0.27 11.1 0.7 1.4 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 RRM_1 PF00076.22 AET40796.1 - 8.5e-06 25.5 0.0 1.6e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AET40796.1 - 0.012 15.8 0.0 0.03 14.5 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif Pkinase PF00069.25 AET40797.1 - 8.5e-49 166.3 0.0 1.3e-48 165.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET40797.1 - 4.4e-23 81.9 0.0 6.9e-23 81.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AET40797.1 - 0.012 14.6 0.1 0.012 14.6 0.1 2.4 3 0 0 3 3 3 0 Haspin like kinase domain Ribosomal_L11 PF00298.19 AET40798.1 - 2.6e-28 98.3 0.3 3.7e-28 97.8 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 AET40798.1 - 9.3e-28 95.9 0.3 1.5e-27 95.2 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain JAB PF01398.21 AET40799.1 - 2.2e-28 98.6 0.3 1.3e-27 96.1 0.2 2.3 1 1 1 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UPF0172 PF03665.13 AET40799.1 - 0.0002 21.4 0.0 0.00041 20.4 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) Prok-JAB PF14464.6 AET40799.1 - 0.00064 19.5 0.0 0.0015 18.3 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Tim17 PF02466.19 AET40801.1 - 1.9e-38 131.3 3.9 2.3e-38 131.0 3.9 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Gly-zipper_Omp PF13488.6 AET40801.1 - 0.82 9.7 8.3 0.26 11.3 1.5 2.3 2 0 0 2 2 2 0 Glycine zipper Cortex-I_coil PF09304.10 AET40802.1 - 0.043 14.0 3.0 0.64 10.3 0.1 2.8 3 0 0 3 3 3 0 Cortexillin I, coiled coil Arm PF00514.23 AET40803.1 - 4.1e-88 287.0 14.8 1.9e-13 49.9 0.3 8.6 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 AET40803.1 - 1.4e-27 96.0 9.4 4.2e-27 94.4 9.2 2.0 2 0 0 2 2 1 1 Importin beta binding domain Arm_3 PF16186.5 AET40803.1 - 1.3e-21 75.9 2.9 2.9e-20 71.6 4.2 2.5 3 0 0 3 3 3 1 Atypical Arm repeat HEAT_EZ PF13513.6 AET40803.1 - 2.8e-18 66.0 4.2 3.6e-05 24.2 0.0 6.5 5 2 3 8 8 7 3 HEAT-like repeat HEAT_2 PF13646.6 AET40803.1 - 2.8e-15 56.5 0.2 0.0003 21.1 0.0 5.0 2 1 4 6 6 6 5 HEAT repeats HEAT PF02985.22 AET40803.1 - 2.7e-13 48.9 0.0 0.027 14.7 0.0 6.4 6 0 0 6 6 6 2 HEAT repeat RICTOR_V PF14668.6 AET40803.1 - 2.3e-06 27.7 2.9 0.055 13.7 0.0 5.2 3 3 3 6 6 6 1 Rapamycin-insensitive companion of mTOR, domain 5 V-ATPase_H_C PF11698.8 AET40803.1 - 1.2e-05 25.4 1.1 0.31 11.2 0.0 4.4 4 2 2 6 6 6 3 V-ATPase subunit H Arm_2 PF04826.13 AET40803.1 - 1.8e-05 24.3 1.0 6 6.2 0.2 4.0 2 1 1 4 4 4 4 Armadillo-like NopRA1 PF16201.5 AET40803.1 - 2.6e-05 23.9 0.0 0.91 9.1 0.0 5.0 2 1 1 4 4 4 2 Nucleolar pre-ribosomal-associated protein 1 Adaptin_N PF01602.20 AET40803.1 - 3.4e-05 22.6 1.0 0.0025 16.5 0.4 2.6 1 1 0 2 2 2 1 Adaptin N terminal region Atx10homo_assoc PF09759.9 AET40803.1 - 0.00057 19.9 0.1 1.1 9.4 0.0 4.1 4 0 0 4 4 4 1 Spinocerebellar ataxia type 10 protein domain FAST_1 PF06743.15 AET40803.1 - 0.02 14.8 1.3 1.2 9.2 0.0 3.3 4 0 0 4 4 4 0 FAST kinase-like protein, subdomain 1 PUL PF08324.11 AET40803.1 - 1 8.5 4.7 5.6 6.1 0.1 3.1 2 1 1 3 3 3 0 PUL domain GATase_4 PF13230.6 AET40805.1 - 2.7e-16 59.3 0.0 3.7e-14 52.3 0.0 2.1 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.6 AET40805.1 - 7e-11 42.5 0.0 1.2e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 AET40805.1 - 0.12 12.3 0.0 0.32 10.9 0.0 1.7 2 0 0 2 2 2 0 Glutamine amidotransferase domain Tyr_Deacylase PF02580.16 AET40806.1 - 9.2e-47 159.2 0.1 1e-46 159.0 0.1 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase DUF2121 PF09894.9 AET40806.1 - 0.0085 15.7 0.6 0.01 15.4 0.6 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2121) Peptidase_C15 PF01470.17 AET40806.1 - 0.035 14.3 0.0 0.041 14.0 0.0 1.1 1 0 0 1 1 1 0 Pyroglutamyl peptidase Chitin_synth_1 PF01644.17 AET40807.1 - 2.3e-70 235.8 0.1 3.6e-70 235.1 0.1 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 AET40807.1 - 7e-28 96.4 0.2 2.6e-27 94.6 0.1 2.0 2 0 0 2 2 2 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 AET40807.1 - 1.7e-17 63.2 7.5 1.2e-14 53.8 0.2 2.6 1 1 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 AET40807.1 - 5.8e-10 39.4 4.9 5.8e-10 39.4 4.9 2.6 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 AET40807.1 - 0.0035 17.2 0.0 1.5 8.6 0.0 2.6 2 0 0 2 2 2 2 Glycosyl transferase family 2 DUF2207 PF09972.9 AET40807.1 - 3.2 6.4 14.2 0.05 12.4 0.3 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) CDC13_N PF16853.5 AET40809.1 - 1.7e-70 236.8 7.6 4.4e-70 235.4 7.6 1.8 1 0 0 1 1 1 1 Cell division control protein 13 N-terminus Cdc13_OB4_dimer PF18233.1 AET40809.1 - 1.2e-45 154.3 0.0 3.4e-45 152.8 0.0 1.9 1 0 0 1 1 1 1 Cdc13 OB4 dimerization domain POT1 PF02765.17 AET40809.1 - 3.3e-09 36.7 2.1 8.6e-09 35.4 2.1 1.8 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 Cdc13_OB2 PF18691.1 AET40809.1 - 0.00032 20.8 3.5 0.00033 20.7 1.0 2.3 2 0 0 2 2 2 1 Cell division control protein 13, OB2 domain SUR7 PF06687.12 AET40810.1 - 8.4e-32 110.5 7.2 1.2e-31 110.0 7.2 1.2 1 0 0 1 1 1 1 SUR7/PalI family ABC2_membrane_3 PF12698.7 AET40810.1 - 0.03 13.5 7.8 0.085 11.9 7.8 1.7 1 0 0 1 1 1 0 ABC-2 family transporter protein Wzy_C_2 PF11846.8 AET40810.1 - 0.2 11.6 2.6 0.14 12.1 0.3 1.8 1 1 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal MARVEL PF01284.23 AET40810.1 - 0.35 10.9 10.5 0.036 14.1 5.1 2.0 2 1 0 2 2 2 0 Membrane-associating domain DUF4278 PF14105.6 AET40810.1 - 1.9 9.0 7.1 41 4.7 6.9 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4278) DUF3328 PF11807.8 AET40810.1 - 7.3 6.3 14.7 3.4 7.4 0.2 3.4 2 1 0 3 3 3 0 Domain of unknown function (DUF3328) RRM_1 PF00076.22 AET40812.1 - 2.1e-17 62.7 0.0 8.4e-16 57.6 0.0 2.9 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CobN-Mg_chel PF02514.16 AET40812.1 - 0.0065 14.3 7.6 0.0089 13.8 7.6 1.1 1 0 0 1 1 1 1 CobN/Magnesium Chelatase Membralin PF09746.9 AET40812.1 - 0.049 12.7 9.7 0.082 11.9 9.7 1.3 1 0 0 1 1 1 0 Tumour-associated protein CCSAP PF15748.5 AET40812.1 - 0.13 12.4 26.1 0.32 11.1 26.1 1.6 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF4746 PF15928.5 AET40812.1 - 0.18 11.2 9.2 0.29 10.5 9.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) eIF-3_zeta PF05091.12 AET40812.1 - 0.18 10.7 23.6 0.28 10.1 23.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF2828 PF11443.8 AET40812.1 - 0.42 8.6 13.3 0.59 8.2 13.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Tim54 PF11711.8 AET40812.1 - 0.96 8.2 18.3 1.5 7.5 18.3 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Paf1 PF03985.13 AET40812.1 - 0.98 8.3 22.7 1.5 7.8 22.7 1.2 1 0 0 1 1 1 0 Paf1 DUF4471 PF14740.6 AET40812.1 - 1.3 8.1 11.9 1.8 7.7 7.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) DUF4407 PF14362.6 AET40812.1 - 1.8 7.8 17.5 3 7.1 17.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RR_TM4-6 PF06459.12 AET40812.1 - 4 7.2 22.4 7.1 6.4 22.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SID-1_RNA_chan PF13965.6 AET40812.1 - 4.7 5.5 10.1 7.7 4.8 10.1 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Hid1 PF12722.7 AET40812.1 - 7.1 4.6 22.2 13 3.8 22.2 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PIP5K PF01504.18 AET40812.1 - 7.1 5.8 15.3 14 4.8 15.3 1.5 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase CLN3 PF02487.17 AET40812.1 - 7.4 5.5 16.6 12 4.8 16.6 1.3 1 0 0 1 1 1 0 CLN3 protein Baculo_PP31 PF05311.11 AET40812.1 - 7.9 5.9 20.2 16 4.9 20.2 1.4 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Septin PF00735.18 AET40813.1 - 2.9e-76 256.4 3.3 6.6e-69 232.3 0.1 2.7 3 0 0 3 3 3 2 Septin AAA_33 PF13671.6 AET40813.1 - 0.00032 20.9 0.3 0.00096 19.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 AET40813.1 - 0.00049 19.9 0.0 0.0011 18.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AET40813.1 - 0.00073 20.0 0.6 0.0098 16.3 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AET40813.1 - 0.00094 19.5 0.1 0.0053 17.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 AET40813.1 - 0.0033 17.5 0.1 0.027 14.5 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_5 PF07728.14 AET40813.1 - 0.0033 17.4 0.0 0.0087 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AIG1 PF04548.16 AET40813.1 - 0.0034 16.8 2.1 0.0041 16.5 0.0 2.1 2 0 0 2 2 2 1 AIG1 family AAA_7 PF12775.7 AET40813.1 - 0.0034 16.9 0.0 0.0069 15.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region GTP_EFTU PF00009.27 AET40813.1 - 0.0035 16.9 0.6 0.014 14.9 0.0 2.2 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain AAA_18 PF13238.6 AET40813.1 - 0.0045 17.5 0.0 0.013 16.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 AET40813.1 - 0.0065 16.9 0.3 0.016 15.7 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 AET40813.1 - 0.013 15.4 0.6 0.049 13.5 0.0 2.2 3 0 0 3 3 3 0 RsgA GTPase Sigma54_activat PF00158.26 AET40813.1 - 0.016 14.9 0.1 0.056 13.2 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain RNA_helicase PF00910.22 AET40813.1 - 0.017 15.5 0.0 0.062 13.7 0.0 2.0 2 0 0 2 2 1 0 RNA helicase Roc PF08477.13 AET40813.1 - 0.02 15.1 0.0 0.059 13.6 0.0 1.9 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 AET40813.1 - 0.024 14.7 0.8 0.17 11.9 0.0 2.6 3 0 0 3 3 3 0 Dynamin family Mg_chelatase PF01078.21 AET40813.1 - 0.025 14.0 0.0 0.061 12.7 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Pox_A32 PF04665.12 AET40813.1 - 0.052 13.0 0.0 0.052 13.0 0.0 1.8 3 0 0 3 3 2 0 Poxvirus A32 protein AAA_25 PF13481.6 AET40813.1 - 0.058 13.0 0.0 0.21 11.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 AET40813.1 - 0.067 12.3 4.4 0.084 12.0 0.0 2.3 2 2 0 2 2 2 0 G-protein alpha subunit AAA_23 PF13476.6 AET40813.1 - 0.072 13.6 9.0 2.6 8.5 3.5 2.7 3 0 0 3 3 2 0 AAA domain MobB PF03205.14 AET40813.1 - 0.1 12.5 0.1 3.7 7.5 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.17 AET40813.1 - 0.1 12.6 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 AET40813.1 - 0.11 12.4 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 NACHT domain LMBR1 PF04791.16 AET40813.1 - 0.14 11.0 1.2 0.2 10.5 1.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Sigma54_activ_2 PF14532.6 AET40813.1 - 0.18 11.9 1.1 0.32 11.1 0.0 1.9 2 0 0 2 2 1 0 Sigma-54 interaction domain AAA_28 PF13521.6 AET40813.1 - 0.2 11.9 1.4 0.23 11.7 0.0 1.8 2 0 0 2 2 1 0 AAA domain NB-ARC PF00931.22 AET40813.1 - 0.23 10.6 2.2 0.59 9.3 0.0 2.4 2 1 0 2 2 2 0 NB-ARC domain ABC_tran PF00005.27 AET40813.1 - 0.25 11.9 0.1 0.25 11.9 0.1 2.5 2 1 0 2 2 2 0 ABC transporter PKcGMP_CC PF16808.5 AET40814.1 - 0.018 14.9 7.3 0.018 14.9 7.3 2.4 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase YjeF_N PF03853.15 AET40815.1 - 4.3e-37 127.6 0.0 5.3e-37 127.3 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus DUF429 PF04250.13 AET40815.1 - 0.071 12.9 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF429) SMK-1 PF04802.15 AET40816.1 - 9.8e-58 195.1 5.0 9.8e-58 195.1 5.0 2.2 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 WH1 PF00568.23 AET40816.1 - 0.0014 18.5 0.0 0.0036 17.2 0.0 1.7 1 0 0 1 1 1 1 WH1 domain adh_short_C2 PF13561.6 AET40817.1 - 2.4e-46 158.2 3.2 2.8e-46 158.0 3.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 AET40817.1 - 8.4e-35 120.0 3.8 1.1e-34 119.7 3.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 AET40817.1 - 1.8e-11 44.3 2.2 2.7e-11 43.7 2.2 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 AET40817.1 - 0.032 13.6 0.0 0.08 12.3 0.0 1.4 1 1 0 2 2 2 0 Fungal family of unknown function (DUF1776) ArfGap PF01412.18 AET40818.1 - 2.1e-31 108.4 0.0 5.7e-31 107.0 0.0 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf ADD_DNMT3 PF17980.1 AET40818.1 - 0.032 14.2 1.7 8.2 6.5 0.0 2.4 2 0 0 2 2 2 0 Cysteine rich ADD domain in DNMT3 PH_18 PF18469.1 AET40819.1 - 8.3e-48 161.9 0.4 8.3e-48 161.9 0.4 2.1 2 1 0 2 2 2 1 Pleckstrin homology domain Rtt106 PF08512.12 AET40819.1 - 5.9e-30 103.5 0.6 5.9e-30 103.5 0.6 1.9 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Rtt106_N PF18215.1 AET40819.1 - 1.3e-06 28.1 0.0 3.3e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 Histone chaperone Rtt106 N-terminal domain Topoisom_I_N PF02919.15 AET40819.1 - 1.5 8.3 5.2 0.7 9.4 2.4 1.9 2 0 0 2 2 2 0 Eukaryotic DNA topoisomerase I, DNA binding fragment RIO1 PF01163.22 AET40820.1 - 7.3e-43 146.4 0.2 1.1e-42 145.8 0.2 1.2 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 AET40820.1 - 2.2e-31 107.9 0.2 5.1e-31 106.7 0.2 1.6 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 AET40820.1 - 2.6e-08 34.1 0.6 0.00064 19.7 0.0 2.8 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 AET40820.1 - 0.00025 20.5 0.1 0.0099 15.2 0.1 2.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 AET40820.1 - 0.0017 17.8 0.1 0.003 17.0 0.1 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 AET40820.1 - 0.089 11.6 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase VID27 PF08553.10 AET40822.1 - 7.5e-159 528.5 1.8 1.2e-158 527.9 1.8 1.3 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 AET40822.1 - 2e-55 187.3 1.0 5.4e-55 185.9 1.0 1.8 1 0 0 1 1 1 1 VID27 N-terminal region VID27_PH PF17747.1 AET40822.1 - 2.9e-25 88.7 0.1 6.1e-24 84.4 0.2 2.6 2 0 0 2 2 2 1 VID27 PH-like domain Mrx7 PF10906.8 AET40823.1 - 5.3e-28 97.1 0.4 6.6e-28 96.8 0.4 1.1 1 0 0 1 1 1 1 MIOREX complex component 7 Ost4 PF10215.9 AET40824.1 - 4e-15 55.3 2.8 4.4e-15 55.2 2.8 1.0 1 0 0 1 1 1 1 Oligosaccaryltransferase UcrQ PF02939.16 AET40824.1 - 0.072 13.0 0.0 0.075 13.0 0.0 1.1 1 0 0 1 1 1 0 UcrQ family FUSC_2 PF13515.6 AET40825.1 - 2.3e-06 27.7 25.0 4.3e-06 26.9 5.7 2.8 2 0 0 2 2 2 2 Fusaric acid resistance protein-like ArAE_2 PF10334.9 AET40825.1 - 5.3e-05 23.2 0.0 0.00013 21.9 0.0 1.6 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 FUSC PF04632.12 AET40825.1 - 0.059 11.9 6.1 5.4 5.4 2.0 3.1 2 1 1 3 3 3 0 Fusaric acid resistance protein family ArAE_2_N PF10337.9 AET40825.1 - 0.073 12.1 10.5 0.094 11.7 3.2 3.1 4 0 0 4 4 4 0 Putative ER transporter, 6TM, N-terminal Y_phosphatase PF00102.27 AET40826.1 - 5e-53 180.1 0.0 8.5e-53 179.3 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 AET40826.1 - 0.0011 18.8 0.0 0.0026 17.6 0.0 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 AET40826.1 - 0.0026 17.7 0.0 0.0057 16.6 0.0 1.6 2 0 0 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 AET40826.1 - 0.027 14.6 0.0 0.08 13.1 0.0 1.8 2 0 0 2 2 2 0 Inositol hexakisphosphate KH_1 PF00013.29 AET40827.1 - 2.2e-07 30.6 0.9 3e-07 30.2 0.1 1.7 2 0 0 2 2 2 1 KH domain HSP70 PF00012.20 AET40828.1 - 1.8e-230 766.3 7.9 2e-230 766.1 7.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AET40828.1 - 2.1e-17 63.0 1.0 6e-16 58.2 0.4 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 AET40828.1 - 0.00017 21.4 0.0 0.00034 20.4 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 AET40828.1 - 0.32 11.4 6.8 4.9 7.6 0.2 3.6 3 2 0 3 3 3 0 Cell division protein FtsA Flagellin_N PF00669.20 AET40828.1 - 0.57 10.3 3.6 1.4 9.0 3.6 1.6 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region ATP-synt_DE PF00401.20 AET40828.1 - 7.9 6.8 8.1 9 6.6 0.3 3.5 2 1 1 3 3 3 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain Neugrin PF06413.11 AET40829.1 - 1e-08 35.5 0.4 1e-08 35.5 0.4 1.5 2 0 0 2 2 2 1 Neugrin Sigma70_r4 PF04545.16 AET40829.1 - 0.005 16.3 0.1 0.0098 15.4 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_32 PF13565.6 AET40829.1 - 0.027 15.1 0.9 0.035 14.7 0.0 1.7 2 0 0 2 2 2 0 Homeodomain-like domain HTH_Crp_2 PF13545.6 AET40829.1 - 0.059 13.4 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Autoind_synth PF00765.17 AET40829.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 Autoinducer synthase HTH_11 PF08279.12 AET40829.1 - 0.12 12.4 0.0 0.34 10.9 0.0 1.8 1 0 0 1 1 1 0 HTH domain Lactamase_B_6 PF16661.5 AET40829.1 - 0.14 11.6 0.0 0.6 9.5 0.0 1.9 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily domain Baculo_11_kDa PF06143.11 AET40830.1 - 0.14 11.7 0.0 0.34 10.5 0.0 1.6 1 0 0 1 1 1 0 Baculovirus 11 kDa family SHE3 PF17078.5 AET40830.1 - 0.4 10.4 5.2 0.51 10.0 3.2 2.0 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 LIM_bind PF01803.16 AET40831.1 - 2.9e-66 223.4 0.0 2.9e-66 223.4 0.0 2.5 2 1 0 2 2 2 1 LIM-domain binding protein PAPA-1 PF04795.12 AET40832.1 - 1.1e-19 71.0 6.5 1.1e-19 71.0 6.5 3.6 2 1 0 2 2 2 1 PAPA-1-like conserved region RabGAP-TBC PF00566.18 AET40833.1 - 9.4e-35 120.2 9.9 1.5e-30 106.5 5.4 2.4 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Rap1-DNA-bind PF09197.10 AET40834.1 - 2.3e-49 166.5 4.1 1.5e-45 154.3 0.5 2.9 2 0 0 2 2 2 2 Rap1, DNA-binding Rap1_C PF11626.8 AET40834.1 - 7.5e-23 80.4 0.0 9.2e-22 76.9 0.0 2.6 3 0 0 3 3 3 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-binding PF00249.31 AET40834.1 - 4.4e-15 55.6 0.1 9.8e-12 44.9 0.0 4.2 4 0 0 4 4 4 1 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.11 AET40834.1 - 1.3e-08 34.9 0.8 9.3e-05 22.5 0.0 2.7 2 0 0 2 2 2 2 Rap1 Myb domain BRCT_2 PF16589.5 AET40834.1 - 8.5e-07 29.3 0.1 6e-06 26.6 0.0 2.5 3 0 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 AET40834.1 - 0.00065 20.0 0.4 0.0037 17.6 0.0 2.5 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain Myb_DNA-bind_6 PF13921.6 AET40834.1 - 0.015 15.5 0.2 0.32 11.3 0.0 2.9 3 0 0 3 3 3 0 Myb-like DNA-binding domain SLIDE PF09111.10 AET40834.1 - 0.021 14.9 0.1 0.15 12.1 0.0 2.5 2 0 0 2 2 2 0 SLIDE MiaE_2 PF13794.6 AET40834.1 - 0.92 9.2 3.4 3.1 7.5 0.0 2.7 3 0 0 3 3 3 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like Metallophos PF00149.28 AET40835.1 - 2.6e-12 47.7 0.0 1e-11 45.7 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AET40835.1 - 8.8e-05 22.8 0.0 0.00042 20.5 0.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Hpt PF01627.23 AET40836.1 - 2.4e-11 43.7 0.1 3.1e-11 43.4 0.1 1.2 1 0 0 1 1 1 1 Hpt domain Glyco_hydro_10 PF00331.20 AET40836.1 - 0.14 11.3 0.0 0.25 10.5 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 MgsA_C PF12002.8 AET40837.1 - 5.8e-53 179.2 0.3 1.3e-52 178.1 0.3 1.6 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 AET40837.1 - 1.1e-21 77.0 0.1 3.2e-21 75.5 0.1 1.9 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 AET40837.1 - 3.5e-15 56.6 0.0 7.4e-15 55.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 AET40837.1 - 2.9e-14 53.1 0.0 1.1e-13 51.3 0.0 1.9 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AET40837.1 - 4.7e-07 30.4 0.0 7.5e-05 23.2 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 AET40837.1 - 5.6e-07 29.6 0.1 2.2e-06 27.7 0.1 2.1 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AET40837.1 - 3.5e-05 24.1 0.6 0.00054 20.2 0.2 2.9 2 1 0 2 2 1 1 AAA domain Sigma54_activat PF00158.26 AET40837.1 - 5.7e-05 22.9 0.1 0.0025 17.5 0.1 2.5 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_14 PF13173.6 AET40837.1 - 7.7e-05 22.7 0.0 0.00019 21.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 AET40837.1 - 0.0002 20.8 0.1 0.064 12.6 0.0 2.3 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 AET40837.1 - 0.00085 19.7 0.0 0.0029 18.0 0.0 2.0 1 0 0 1 1 1 1 RNA helicase AAA_19 PF13245.6 AET40837.1 - 0.0014 18.9 0.0 2 8.7 0.0 2.4 1 1 1 2 2 2 2 AAA domain DNA_pol3_delta2 PF13177.6 AET40837.1 - 0.0019 18.0 0.1 0.36 10.6 0.3 2.7 2 1 1 3 3 3 2 DNA polymerase III, delta subunit AAA_2 PF07724.14 AET40837.1 - 0.0034 17.5 0.0 0.0074 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 AET40837.1 - 0.0036 17.8 0.0 0.0096 16.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 AET40837.1 - 0.0037 17.0 0.0 0.0081 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 AET40837.1 - 0.0041 17.0 0.0 0.0087 15.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 AET40837.1 - 0.0067 16.4 1.4 0.16 12.0 0.2 2.7 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit IstB_IS21 PF01695.17 AET40837.1 - 0.015 15.0 0.0 0.035 13.8 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein TniB PF05621.11 AET40837.1 - 0.016 14.6 0.0 0.54 9.6 0.0 2.4 1 1 1 2 2 2 0 Bacterial TniB protein ABC_tran PF00005.27 AET40837.1 - 0.018 15.6 0.0 0.058 13.9 0.0 1.9 1 0 0 1 1 1 0 ABC transporter DUF815 PF05673.13 AET40837.1 - 0.019 14.2 0.2 0.039 13.1 0.0 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF815) Bac_DnaA PF00308.18 AET40837.1 - 0.02 14.8 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_7 PF12775.7 AET40837.1 - 0.022 14.3 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 AET40837.1 - 0.023 14.4 0.0 0.07 12.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.13 AET40837.1 - 0.027 13.7 0.0 0.06 12.5 0.0 1.6 1 0 0 1 1 1 0 TIP49 P-loop domain zf_UBZ PF18439.1 AET40837.1 - 0.036 13.7 0.1 0.097 12.3 0.1 1.8 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger KTI12 PF08433.10 AET40837.1 - 0.052 13.0 0.2 0.18 11.2 0.0 1.9 2 0 0 2 2 2 0 Chromatin associated protein KTI12 T2SSE PF00437.20 AET40837.1 - 0.078 12.0 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Viral_helicase1 PF01443.18 AET40837.1 - 0.085 12.6 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RNA_pol_Rpb5_N PF03871.14 AET40837.1 - 0.17 12.5 0.7 2.1 9.0 0.1 2.6 2 0 0 2 2 2 0 RNA polymerase Rpb5, N-terminal domain RusA PF05866.11 AET40837.1 - 0.22 12.1 1.0 0.6 10.7 0.1 2.1 2 0 0 2 2 2 0 Endodeoxyribonuclease RusA Hydrolase_6 PF13344.6 AET40838.1 - 7.6e-30 103.0 0.0 4.2e-29 100.6 0.0 2.0 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AET40838.1 - 2.1e-15 56.5 0.0 3.5e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 AET40838.1 - 4.6e-12 46.7 0.0 1.4e-11 45.1 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AET40838.1 - 2.3e-06 27.8 0.1 0.0015 18.6 0.0 2.5 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Glyco_transf_22 PF03901.17 AET40839.1 - 5.9e-91 305.8 28.3 7.3e-91 305.5 28.3 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF996 PF06195.13 AET40839.1 - 0.53 10.6 14.2 0.56 10.5 0.9 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF996) Adenylsucc_synt PF00709.21 AET40840.1 - 6.6e-176 585.3 0.0 7.5e-176 585.1 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase POP1 PF06978.11 AET40841.1 - 5.9e-78 261.6 13.6 5.9e-78 261.6 13.6 1.6 2 0 0 2 2 2 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 AET40841.1 - 3.2e-29 101.1 0.4 9.6e-29 99.6 0.4 1.9 1 0 0 1 1 1 1 POPLD (NUC188) domain GCV_T_C PF08669.11 AET40841.1 - 0.036 14.0 0.0 0.077 12.9 0.0 1.5 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain T4SS PF07996.11 AET40841.1 - 0.12 12.7 0.8 0.39 11.1 0.8 1.8 1 0 0 1 1 1 0 Type IV secretion system proteins GDPD_2 PF13653.6 AET40843.1 - 0.036 14.5 0.5 0.072 13.6 0.5 1.5 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family GDPD PF03009.17 AET40843.1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Ssu72 PF04722.13 AET40844.1 - 5.3e-84 280.5 0.0 6e-84 280.4 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein Peptidase_C54 PF03416.19 AET40845.1 - 3e-85 286.0 0.0 3.8e-85 285.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 G-patch PF01585.23 AET40846.1 - 4.2e-12 45.8 0.7 8.4e-12 44.8 0.7 1.5 1 0 0 1 1 1 1 G-patch domain R3H PF01424.22 AET40846.1 - 0.13 12.3 0.0 0.49 10.4 0.0 2.0 2 0 0 2 2 2 0 R3H domain SID PF11778.8 AET40847.1 - 9.5e-55 184.4 7.2 9.5e-55 184.4 7.2 2.6 3 0 0 3 3 2 1 Septation initiation UPF0242 PF06785.11 AET40847.1 - 4.9e-05 23.5 109.0 5.9e-05 23.3 17.0 5.5 2 2 2 4 4 4 3 Uncharacterised protein family (UPF0242) N-terminus TMF_DNA_bd PF12329.8 AET40847.1 - 0.0019 18.2 9.1 0.0019 18.2 9.1 9.2 2 2 6 9 9 7 2 TATA element modulatory factor 1 DNA binding ATG16 PF08614.11 AET40847.1 - 0.0044 17.3 94.7 0.093 12.9 15.6 6.0 2 2 2 4 4 4 2 Autophagy protein 16 (ATG16) SlyX PF04102.12 AET40847.1 - 0.048 14.3 0.9 0.048 14.3 0.9 7.3 5 2 4 9 9 8 0 SlyX CALCOCO1 PF07888.11 AET40847.1 - 0.063 12.1 85.6 0.15 10.9 47.0 2.5 2 1 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.11 AET40847.1 - 0.082 11.8 105.2 0.038 12.9 25.7 5.0 2 2 3 5 5 5 0 Spc7 kinetochore protein Atg14 PF10186.9 AET40847.1 - 0.27 10.3 91.7 0.038 13.1 23.5 4.2 1 1 4 5 5 5 0 Vacuolar sorting 38 and autophagy-related subunit 14 HMMR_N PF15905.5 AET40847.1 - 0.84 9.0 107.0 5.5 6.4 10.0 4.4 2 1 2 4 4 4 0 Hyaluronan mediated motility receptor N-terminal Dala_Dala_lig_N PF01820.21 AET40847.1 - 1.2 9.6 0.0 1.2 9.6 0.0 3.3 3 1 0 3 3 3 0 D-ala D-ala ligase N-terminus DUF3584 PF12128.8 AET40847.1 - 1.7 6.1 79.4 0.57 7.6 23.6 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3584) HTH_26 PF13443.6 AET40847.1 - 4.2 7.9 8.7 2.3 8.7 0.2 3.9 3 1 0 3 3 3 0 Cro/C1-type HTH DNA-binding domain DUF4407 PF14362.6 AET40847.1 - 5.9 6.1 58.4 2.3 7.5 12.8 4.3 2 2 2 4 4 4 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 AET40847.1 - 7.6 6.9 91.4 0.21 12.0 20.6 5.3 2 2 3 5 5 4 0 Fez1 GST_C PF00043.25 AET40848.1 - 7.6e-24 83.8 0.0 1.7e-23 82.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 AET40848.1 - 4.5e-18 65.4 0.0 1.7e-17 63.5 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 AET40848.1 - 4.6e-10 39.8 0.0 4.8e-09 36.5 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 AET40848.1 - 6.4e-08 32.8 0.0 3.9e-07 30.3 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 AET40848.1 - 3.9e-06 27.0 0.0 8.5e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 AET40848.1 - 0.015 15.3 0.0 0.031 14.3 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain MFA1_2 PF17317.2 AET40849.1 - 7e-20 70.5 1.4 7.5e-20 70.4 1.4 1.0 1 0 0 1 1 1 1 Mating hormone A-factor 1&2 Elongin_A PF06881.11 AET40850.1 - 4.4e-17 62.5 23.0 1e-16 61.4 11.2 3.5 3 1 0 3 3 3 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Rrf2 PF02082.20 AET40850.1 - 0.13 12.6 4.3 10 6.6 0.1 3.2 3 0 0 3 3 3 0 Transcriptional regulator YqfD PF06898.11 AET40850.1 - 0.6 8.9 5.9 0.92 8.3 5.9 1.3 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD CRAL_TRIO PF00650.20 AET40851.1 - 3.2e-41 140.7 0.0 4.7e-41 140.2 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 AET40851.1 - 2.3e-15 56.5 0.6 5.2e-15 55.4 0.1 1.9 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 AET40851.1 - 0.11 12.6 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain EXOSC1 PF10447.9 AET40852.1 - 1.5e-38 131.8 1.8 1.1e-37 129.0 0.1 2.1 2 0 0 2 2 2 1 Exosome component EXOSC1/CSL4 Globin PF00042.22 AET40853.1 - 6.7e-07 29.8 0.0 3.1e-06 27.7 0.0 2.1 2 0 0 2 2 2 1 Globin Peptidase_S8 PF00082.22 AET40854.1 - 2.9e-33 115.4 2.3 2.9e-33 115.4 2.3 1.7 2 0 0 2 2 2 1 Subtilase family P_proprotein PF01483.20 AET40854.1 - 4.2e-25 87.6 0.6 8.1e-25 86.7 0.6 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain Peptidase_C1_2 PF03051.15 AET40855.1 - 2.1e-161 537.6 0.3 2.5e-161 537.4 0.3 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 AET40855.1 - 5.4e-08 33.2 0.1 0.00031 20.9 0.3 2.4 2 0 0 2 2 2 2 Papain family cysteine protease Fe_hyd_lg_C PF02906.14 AET40856.1 - 1.6e-63 214.6 0.0 2.2e-63 214.1 0.0 1.2 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain G6PD_C PF02781.16 AET40857.1 - 3.3e-109 364.6 0.0 4.5e-109 364.1 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 AET40857.1 - 3.5e-58 197.1 0.0 1e-57 195.6 0.0 1.7 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain RhoGAP PF00620.27 AET40858.1 - 2.5e-33 115.1 0.4 1.2e-32 112.8 0.1 2.2 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 AET40858.1 - 7.3e-23 80.6 59.2 4.8e-09 36.3 10.7 4.8 5 0 0 5 5 5 4 LIM domain ATG2_CAD PF13329.6 AET40859.1 - 2.1e-34 118.5 1.7 2.1e-34 118.5 1.7 3.0 3 0 0 3 3 3 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.11 AET40859.1 - 2e-30 105.0 0.9 9.6e-30 102.8 0.3 2.2 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 AET40859.1 - 0.019 14.8 0.0 0.077 12.8 0.0 2.1 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal SNO PF01174.19 AET40860.1 - 3.3e-71 239.0 0.0 3.8e-71 238.8 0.0 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 AET40860.1 - 8.1e-09 35.3 0.0 1.8e-08 34.2 0.0 1.5 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 AET40860.1 - 0.00033 20.5 0.1 0.001 18.9 0.1 1.7 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_S51 PF03575.17 AET40860.1 - 0.00076 19.2 0.1 0.0015 18.2 0.0 1.5 2 0 0 2 2 2 1 Peptidase family S51 BPL_N PF09825.9 AET40860.1 - 0.0021 17.2 0.1 0.0095 15.1 0.0 1.8 2 0 0 2 2 2 1 Biotin-protein ligase, N terminal ThiJ_like PF17124.5 AET40860.1 - 0.014 15.1 0.0 0.034 13.9 0.0 1.6 1 1 0 2 2 2 0 ThiJ/PfpI family-like DJ-1_PfpI PF01965.24 AET40860.1 - 0.02 14.7 0.0 0.036 13.9 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family SOR_SNZ PF01680.17 AET40861.1 - 9.3e-102 339.1 2.4 1.2e-101 338.8 2.4 1.1 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 AET40861.1 - 1.3e-09 37.8 3.8 1.3e-06 27.9 0.1 2.5 2 1 0 2 2 2 2 Thiazole biosynthesis protein ThiG NanE PF04131.14 AET40861.1 - 0.0027 16.9 2.3 0.41 9.8 0.0 3.3 3 1 0 3 3 3 2 Putative N-acetylmannosamine-6-phosphate epimerase IGPS PF00218.21 AET40861.1 - 0.0065 15.7 0.0 0.18 11.0 0.0 2.3 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase Dus PF01207.17 AET40861.1 - 0.0067 15.6 0.5 4.1 6.4 0.0 2.8 2 1 1 3 3 3 2 Dihydrouridine synthase (Dus) TetR_C_27 PF17935.1 AET40861.1 - 0.0085 16.1 0.0 0.019 15.0 0.0 1.5 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain NMO PF03060.15 AET40861.1 - 0.023 14.1 0.9 0.47 9.8 0.0 2.2 2 0 0 2 2 2 0 Nitronate monooxygenase Peptidase_S66C PF17676.1 AET40861.1 - 0.076 13.5 0.0 0.25 11.9 0.0 1.9 2 0 0 2 2 2 0 LD-carboxypeptidase C-terminal domain TMP-TENI PF02581.17 AET40861.1 - 0.085 12.2 0.6 0.53 9.6 0.0 2.5 3 1 1 4 4 4 0 Thiamine monophosphate synthase RRM_1 PF00076.22 AET40862.1 - 0.00043 20.0 0.0 0.026 14.3 0.0 2.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PilN PF05137.13 AET40862.1 - 0.13 12.4 0.4 0.28 11.3 0.4 1.6 1 0 0 1 1 1 0 Fimbrial assembly protein (PilN) CAF1 PF04857.20 AET40863.1 - 1.3e-14 54.2 0.5 1.3e-09 37.7 0.1 2.1 2 0 0 2 2 2 2 CAF1 family ribonuclease RnlB_antitoxin PF15933.5 AET40863.1 - 0.039 14.2 0.2 1.9 8.8 0.0 2.4 1 1 1 2 2 2 0 Antitoxin to bacterial toxin RNase LS or RnlA NTF2 PF02136.20 AET40864.1 - 9.1e-21 74.6 0.3 2e-20 73.6 0.3 1.6 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 AET40864.1 - 0.085 12.7 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MCD PF05292.11 AET40864.1 - 3.1 7.3 10.9 36 3.8 0.0 2.5 2 1 0 2 2 2 0 Malonyl-CoA decarboxylase C-terminal domain Y_phosphatase2 PF03162.13 AET40865.1 - 1.3e-32 112.7 2.1 1.4e-30 106.1 2.1 2.3 1 1 0 1 1 1 1 Tyrosine phosphatase family DUF3750 PF12570.8 AET40865.1 - 0.14 12.9 0.0 5.9 7.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3750) Sacchrp_dh_C PF16653.5 AET40866.1 - 9.3e-95 317.7 0.0 1.3e-94 317.2 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 AET40866.1 - 1.2e-25 90.3 0.9 1.7e-25 89.8 0.9 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 AET40866.1 - 1.1e-09 38.5 1.0 6.2e-09 36.0 0.1 2.1 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 AET40866.1 - 1.3e-07 31.7 0.8 2.1e-07 31.1 0.2 1.7 2 0 0 2 2 2 1 NAD(P)H-binding 3Beta_HSD PF01073.19 AET40866.1 - 0.0006 18.9 0.2 0.001 18.2 0.2 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family F420_oxidored PF03807.17 AET40866.1 - 0.00064 20.3 0.3 0.0012 19.3 0.3 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 AET40866.1 - 0.0012 18.5 0.9 0.0059 16.2 0.3 2.1 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Semialdhyde_dh PF01118.24 AET40866.1 - 0.0013 19.2 0.2 0.0037 17.7 0.1 1.8 1 1 1 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 AET40866.1 - 0.0082 15.5 1.0 0.017 14.5 0.8 1.6 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NmrA PF05368.13 AET40866.1 - 0.011 15.3 0.5 0.018 14.6 0.5 1.3 1 0 0 1 1 1 0 NmrA-like family NAD_binding_3 PF03447.16 AET40866.1 - 0.012 16.3 0.6 0.02 15.6 0.6 1.3 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 AET40866.1 - 0.013 16.4 0.1 0.026 15.4 0.1 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Methyltransf_11 PF08241.12 AET40866.1 - 0.027 15.1 0.0 12 6.6 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Helicase_C PF00271.31 AET40867.1 - 2.6e-14 53.5 0.2 8.1e-14 51.9 0.2 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 AET40867.1 - 2.3e-13 50.3 0.0 6.8e-13 48.8 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold RWD PF05773.22 AET40867.1 - 8.5e-12 45.4 4.2 1.7e-11 44.4 0.5 3.2 3 0 0 3 3 3 1 RWD domain DEAD PF00270.29 AET40867.1 - 8.1e-11 42.0 0.1 2.5e-10 40.4 0.1 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase HA2 PF04408.23 AET40867.1 - 3.6e-08 33.7 1.3 6.5e-08 32.8 0.0 2.2 2 0 0 2 2 1 1 Helicase associated domain (HA2) AAA_22 PF13401.6 AET40867.1 - 0.00065 20.0 0.0 0.0028 17.9 0.0 2.1 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 AET40867.1 - 0.00097 18.3 0.0 0.0018 17.4 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.6 AET40867.1 - 0.0014 18.3 0.0 0.0035 17.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ATPase PF06745.13 AET40867.1 - 0.011 15.1 2.1 0.014 14.7 0.0 2.3 3 0 0 3 3 3 0 KaiC FtsK_SpoIIIE PF01580.18 AET40867.1 - 0.018 14.4 0.0 0.035 13.5 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family TniB PF05621.11 AET40867.1 - 0.021 14.3 0.4 0.31 10.4 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein PhoH PF02562.16 AET40867.1 - 0.029 13.8 0.7 0.38 10.2 0.2 2.9 3 1 0 3 3 3 0 PhoH-like protein AAA_19 PF13245.6 AET40867.1 - 0.046 14.1 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 AET40867.1 - 0.075 12.7 0.0 0.22 11.2 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_14 PF13173.6 AET40867.1 - 0.092 12.8 0.4 3.5 7.7 0.4 3.4 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 AET40867.1 - 0.096 12.6 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 AET40867.1 - 0.2 11.2 0.0 0.47 10.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 AET40867.1 - 0.25 11.8 0.0 0.25 11.8 0.0 5.0 3 1 1 4 4 3 0 AAA domain CDC73_C PF05179.14 AET40868.1 - 4.1e-52 176.0 3.1 4.1e-52 176.0 3.1 1.6 2 0 0 2 2 2 1 RNA pol II accessory factor, Cdc73 family, C-terminal CDC73_N PF16050.5 AET40868.1 - 0.092 12.1 0.1 0.57 9.4 0.0 2.1 2 0 0 2 2 2 0 Paf1 complex subunit CDC73 N-terminal EF-hand_1 PF00036.32 AET40869.1 - 4e-26 88.6 10.5 8.7e-06 24.9 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 AET40869.1 - 3.1e-22 78.8 6.1 5e-13 49.3 2.1 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AET40869.1 - 1.3e-20 71.5 4.7 0.00015 21.4 0.2 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 AET40869.1 - 7.8e-18 63.1 11.9 0.00029 20.2 0.2 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 AET40869.1 - 1.3e-11 44.2 11.7 0.0089 15.9 0.2 4.4 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.7 AET40869.1 - 6.6e-07 29.2 9.4 0.006 16.5 0.3 3.9 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 AET40869.1 - 1.1e-06 28.9 0.1 0.042 14.2 0.1 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 AET40869.1 - 0.0062 16.8 0.1 2.5 8.5 0.0 2.8 2 1 1 3 3 3 1 EF-hand domain Nse4-Nse3_bdg PF15412.6 AET40869.1 - 0.4 10.8 5.9 1.6 8.9 0.8 2.9 2 2 0 2 2 2 0 Binding domain of Nse4/EID3 to Nse3-MAGE Diphthamide_syn PF01866.17 AET40870.1 - 3.1e-68 230.5 0.1 5.1e-68 229.7 0.1 1.4 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Amidohydro_2 PF04909.14 AET40871.1 - 1.7e-05 24.8 0.1 3.1e-05 23.9 0.0 1.5 2 0 0 2 2 2 1 Amidohydrolase DUF1071 PF06378.11 AET40871.1 - 0.15 11.7 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1071) Proteasom_Rpn13 PF04683.13 AET40872.1 - 3.7e-22 78.6 0.0 6.4e-22 77.9 0.0 1.4 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor DHR-2 PF06920.13 AET40873.1 - 3.2e-45 154.8 0.3 3.2e-45 154.8 0.3 2.0 2 0 0 2 2 2 1 Dock homology region 2 DOCK_N PF16172.5 AET40873.1 - 1.5e-12 47.2 0.1 4.7e-12 45.5 0.1 1.8 1 1 0 1 1 1 1 DOCK N-terminus DUF3973 PF13119.6 AET40873.1 - 0.0081 16.2 0.7 0.12 12.5 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3973) KKLCAg1 PF15204.6 AET40873.1 - 0.051 13.7 2.3 0.099 12.8 0.6 2.4 2 0 0 2 2 2 0 Kita-kyushu lung cancer antigen 1 zf-C2H2_assoc PF16606.5 AET40873.1 - 0.65 10.3 2.6 1.5 9.1 2.6 1.5 1 0 0 1 1 1 0 Unstructured conserved, between two C2H2-type zinc-fingers PP-binding PF00550.25 AET40874.1 - 1.5e-12 47.7 0.7 2.1e-12 47.2 0.7 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 AET40874.1 - 2.1e-06 27.9 1.4 3.3e-06 27.2 1.4 1.4 1 1 0 1 1 1 1 Acyl-carrier DUF1493 PF07377.12 AET40874.1 - 0.016 15.7 0.4 0.021 15.3 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) DUF5024 PF16427.5 AET40874.1 - 0.07 13.5 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5024) LRR_4 PF12799.7 AET40875.1 - 9.7e-33 111.7 33.1 9.6e-09 35.4 1.7 7.6 2 2 9 11 11 11 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AET40875.1 - 4.9e-27 93.5 26.2 2.7e-09 36.7 0.9 6.4 4 1 1 6 6 6 5 Leucine rich repeat LRR_9 PF14580.6 AET40875.1 - 1.6e-17 63.6 19.5 1.3e-08 34.6 5.9 4.5 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 AET40875.1 - 1.2e-08 34.3 22.9 0.61 10.8 0.2 10.1 9 2 0 9 9 9 2 Leucine Rich Repeat LRR_6 PF13516.6 AET40875.1 - 1.6e-05 24.5 16.2 7.3 6.9 0.1 7.8 7 0 0 7 7 7 3 Leucine Rich repeat DUF4897 PF16238.5 AET40875.1 - 0.0085 15.9 3.8 0.45 10.4 0.3 2.6 3 0 0 3 3 3 2 Domain of unknown function (DUF4897) tRNA-synt_2b PF00587.25 AET40876.1 - 2.4e-44 151.5 0.0 3.8e-44 150.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 AET40876.1 - 4.7e-15 55.5 0.1 8.5e-15 54.7 0.1 1.4 1 0 0 1 1 1 1 Anticodon binding domain APG17 PF04108.12 AET40877.1 - 4.1e-87 292.9 22.4 4.7e-87 292.7 22.4 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 Med30 PF11315.8 AET40877.1 - 0.0052 17.0 2.2 0.0052 17.0 2.2 3.9 1 1 1 3 3 3 1 Mediator complex subunit 30 Herpes_UL36 PF03586.13 AET40877.1 - 0.021 14.1 1.2 0.45 9.8 0.1 2.5 2 0 0 2 2 2 0 Herpesvirus UL36 tegument protein Band_3_cyto PF07565.13 AET40877.1 - 0.53 10.0 6.0 0.26 11.0 3.4 1.7 1 1 0 1 1 1 0 Band 3 cytoplasmic domain Lip_prot_lig_C PF10437.9 AET40877.1 - 0.6 10.1 5.8 1.5 8.8 0.1 4.0 2 2 1 4 4 4 0 Bacterial lipoate protein ligase C-terminus RhoGEF PF00621.20 AET40877.1 - 1.1 9.4 21.6 2.1 8.6 12.1 3.4 2 2 1 3 3 3 0 RhoGEF domain Cbl_N PF02262.16 AET40877.1 - 3.4 7.7 12.2 4.2 7.4 0.5 3.3 2 2 0 3 3 3 0 CBL proto-oncogene N-terminal domain 1 zf-RING_9 PF13901.6 AET40877.1 - 5.2 7.0 14.5 4.4 7.2 0.6 3.3 2 2 1 3 3 3 0 Putative zinc-RING and/or ribbon WXG100 PF06013.12 AET40877.1 - 7 7.0 7.1 24 5.3 0.1 3.7 3 1 0 4 4 4 0 Proteins of 100 residues with WXG G-patch PF01585.23 AET40878.1 - 2.2e-13 49.9 5.9 4.3e-13 48.9 5.9 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 AET40878.1 - 4.2e-06 26.8 1.4 8.2e-06 25.8 1.4 1.4 1 0 0 1 1 1 1 G-patch domain GCFC PF07842.12 AET40878.1 - 1.5e-05 24.8 0.1 2.7e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein Snapin_Pallidin PF14712.6 AET40878.1 - 0.018 15.4 1.0 0.046 14.1 1.0 1.6 1 0 0 1 1 1 0 Snapin/Pallidin CHCH PF06747.13 AET40879.1 - 2.6e-08 33.8 3.7 4.9e-08 32.9 3.7 1.5 1 0 0 1 1 1 1 CHCH domain GCK PF07802.11 AET40879.1 - 0.0057 17.0 3.5 0.01 16.2 3.5 1.4 1 0 0 1 1 1 1 GCK domain Pik1 PF11522.8 AET40879.1 - 0.035 14.0 0.3 0.076 13.0 0.3 1.6 1 0 0 1 1 1 0 Yeast phosphatidylinositol-4-OH kinase Pik1 Synaptobrevin PF00957.21 AET40880.1 - 4.4e-15 55.2 0.8 7.3e-15 54.5 0.8 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 AET40880.1 - 5.3e-10 39.2 0.0 9.9e-10 38.3 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Herpes_teg_N PF04843.12 AET40880.1 - 0.095 12.4 0.1 0.34 10.6 0.0 1.8 2 0 0 2 2 2 0 Herpesvirus tegument protein, N-terminal conserved region CNH PF00780.22 AET40881.1 - 1e-15 58.1 1.3 3.6e-15 56.3 1.3 1.8 1 1 0 1 1 1 1 CNH domain RhoGEF PF00621.20 AET40881.1 - 4.5e-09 36.8 0.8 9.2e-09 35.8 0.1 2.0 2 0 0 2 2 2 1 RhoGEF domain PH_5 PF15405.6 AET40881.1 - 9e-05 22.6 2.6 0.00039 20.5 2.6 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 AET40881.1 - 0.012 16.1 2.9 0.019 15.5 0.1 2.8 3 0 0 3 3 3 0 PH domain adh_short PF00106.25 AET40882.1 - 8.2e-29 100.5 0.0 1.1e-28 100.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AET40882.1 - 1.9e-19 70.2 0.0 2.6e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AET40882.1 - 1.7e-05 24.8 0.6 0.00035 20.5 0.6 2.1 1 1 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 AET40882.1 - 0.0061 15.6 0.1 0.014 14.4 0.1 1.6 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family SPC25 PF06703.11 AET40883.1 - 6.2e-31 107.4 1.1 7e-31 107.2 1.1 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF3139 PF11337.8 AET40883.1 - 0.05 14.3 1.3 0.081 13.6 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) zf-RING_UBOX PF13445.6 AET40884.1 - 6.2e-08 32.5 1.2 1.1e-07 31.7 0.5 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 AET40884.1 - 2.4e-07 30.5 2.3 8.1e-07 28.8 2.3 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AET40884.1 - 1.5e-05 25.2 5.5 3.3e-05 24.1 4.6 2.0 1 1 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 AET40884.1 - 3.5e-05 23.7 6.6 0.00013 21.8 6.7 2.0 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 AET40884.1 - 0.00015 21.5 6.0 0.00034 20.4 2.2 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AET40884.1 - 0.00051 19.9 6.5 0.011 15.6 6.5 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 AET40884.1 - 0.00055 20.0 5.0 0.0025 18.0 5.0 2.1 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 AET40884.1 - 0.012 15.5 10.6 0.22 11.4 5.5 2.9 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 Prefoldin PF02996.17 AET40884.1 - 0.034 14.1 0.9 35 4.3 2.0 3.5 2 1 0 2 2 2 0 Prefoldin subunit Lar_restr_allev PF14354.6 AET40884.1 - 0.63 10.5 5.3 1.7 9.1 0.6 2.6 2 0 0 2 2 2 0 Restriction alleviation protein Lar FYVE PF01363.21 AET40884.1 - 1.4 9.1 4.9 1.4 9.1 2.5 2.2 1 1 1 2 2 2 0 FYVE zinc finger zf-rbx1 PF12678.7 AET40884.1 - 2.9 8.3 4.9 18 5.7 4.9 2.3 1 1 0 1 1 1 0 RING-H2 zinc finger domain DUF1899 PF08953.11 AET40885.1 - 8.6e-31 105.6 0.4 1.9e-30 104.5 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 AET40885.1 - 4.1e-20 71.4 0.1 1.1e-19 70.0 0.1 1.7 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 AET40885.1 - 1.2e-18 67.0 6.0 2.8e-06 28.0 0.0 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.8 AET40885.1 - 3.2e-08 32.7 0.3 0.0016 17.2 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 AET40885.1 - 2.5e-06 27.7 0.0 0.036 14.4 0.0 4.0 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AET40885.1 - 0.0027 17.6 0.1 0.28 11.0 0.0 2.7 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 AET40885.1 - 0.0029 16.6 0.0 0.52 9.2 0.0 2.3 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein SEN1_N PF12726.7 AET40886.1 - 8.9e-186 619.4 9.3 1.4e-185 618.8 9.3 1.3 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 AET40886.1 - 1.3e-70 238.2 0.7 1.3e-70 238.2 0.7 1.9 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 AET40886.1 - 7.9e-64 215.0 0.8 2.8e-63 213.2 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 AET40886.1 - 4.7e-09 36.7 0.0 9.9e-08 32.4 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AET40886.1 - 9.8e-09 35.2 0.0 0.00026 20.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain UvrD-helicase PF00580.21 AET40886.1 - 8e-08 32.2 0.7 1e-05 25.2 0.0 3.3 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 AET40886.1 - 4.1e-05 23.4 0.9 0.3 10.8 0.0 4.4 5 0 0 5 5 5 2 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 AET40886.1 - 0.046 13.6 0.0 0.18 11.7 0.0 2.1 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain KNTase_C PF07827.11 AET40886.1 - 0.12 12.2 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 KNTase C-terminal domain ZapB PF06005.12 AET40886.1 - 3.4 8.2 5.5 4.8 7.7 3.4 2.4 2 0 0 2 2 2 0 Cell division protein ZapB TFA2_Winged_2 PF18121.1 AET40887.1 - 0.079 12.7 1.0 0.26 11.0 0.1 2.4 2 1 1 3 3 3 0 TFA2 Winged helix domain 2 DUF1664 PF07889.12 AET40887.1 - 2.5 8.2 8.4 0.43 10.6 1.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) IMPDH PF00478.25 AET40888.1 - 1.9e-135 451.4 3.5 2.1e-135 451.2 3.5 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 AET40888.1 - 2.8e-16 59.7 0.0 2e-07 31.3 0.0 2.5 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 AET40888.1 - 1.5e-07 30.8 3.5 3.1e-07 29.7 3.5 1.5 1 1 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 AET40888.1 - 1.2e-06 28.2 7.1 0.0031 17.0 4.8 2.6 2 1 1 3 3 3 2 Nitronate monooxygenase His_biosynth PF00977.21 AET40888.1 - 5.1e-05 22.8 1.6 0.00036 20.1 1.6 2.0 1 1 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.14 AET40888.1 - 0.0037 16.6 1.5 0.0072 15.7 0.6 1.9 1 1 1 2 2 2 1 Thiazole biosynthesis protein ThiG YL1_C PF08265.11 AET40888.1 - 0.017 14.9 0.1 0.035 13.9 0.1 1.6 1 0 0 1 1 1 0 YL1 nuclear protein C-terminal domain Aldolase PF01081.19 AET40888.1 - 0.025 14.0 0.7 0.11 12.0 0.1 2.3 2 0 0 2 2 2 0 KDPG and KHG aldolase PcrB PF01884.17 AET40888.1 - 0.047 13.1 1.6 4.2 6.8 0.0 3.3 2 1 0 3 3 3 0 PcrB family IGPS PF00218.21 AET40888.1 - 0.11 11.7 0.0 0.73 8.9 0.0 2.1 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase Metallophos PF00149.28 AET40889.1 - 4e-36 125.4 0.0 7e-36 124.6 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase WGG PF10273.9 AET40890.1 - 1.1e-25 90.0 0.5 2.4e-25 89.0 0.5 1.6 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 RRP7 PF12923.7 AET40890.1 - 0.05 13.7 0.6 0.088 12.9 0.6 1.4 1 0 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Glyco_transf_15 PF01793.16 AET40891.1 - 4.4e-104 348.3 12.9 5.4e-104 348.0 12.9 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase PAN_2 PF08276.11 AET40891.1 - 0.43 10.7 3.0 0.62 10.2 1.0 2.2 3 0 0 3 3 3 0 PAN-like domain AAA PF00004.29 AET40892.1 - 1.9e-39 135.1 0.0 5e-39 133.8 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AET40892.1 - 1.2e-09 37.8 0.2 6.4e-09 35.5 0.0 2.3 2 0 0 2 2 2 1 AAA+ lid domain RuvB_N PF05496.12 AET40892.1 - 1.8e-05 24.5 0.0 3.6e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 AET40892.1 - 1.9e-05 24.8 1.0 0.00048 20.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 AET40892.1 - 0.00012 21.4 3.5 0.0014 18.0 0.0 2.4 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_22 PF13401.6 AET40892.1 - 0.00015 22.0 0.1 0.0047 17.2 0.1 2.6 1 1 0 1 1 1 1 AAA domain Vps4_C PF09336.10 AET40892.1 - 0.00025 21.0 0.0 0.0009 19.2 0.0 2.0 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_5 PF07728.14 AET40892.1 - 0.0003 20.8 1.6 0.0029 17.6 0.0 3.4 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) TniB PF05621.11 AET40892.1 - 0.0022 17.4 0.0 2.4 7.5 0.0 2.6 1 1 0 2 2 2 2 Bacterial TniB protein AAA_16 PF13191.6 AET40892.1 - 0.0036 17.7 3.2 0.032 14.6 0.0 3.1 2 1 0 3 3 3 1 AAA ATPase domain Mg_chelatase PF01078.21 AET40892.1 - 0.0054 16.1 0.1 0.012 15.0 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 AET40892.1 - 0.007 16.4 0.0 0.022 14.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AET40892.1 - 0.0072 16.5 0.0 0.025 14.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 AET40892.1 - 0.0097 15.7 0.0 0.029 14.1 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_7 PF12775.7 AET40892.1 - 0.033 13.7 0.0 0.097 12.2 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 AET40892.1 - 0.058 13.0 0.0 0.46 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 AET40892.1 - 0.095 13.2 0.1 0.095 13.2 0.1 2.5 3 1 0 3 3 2 0 AAA domain AAA_24 PF13479.6 AET40892.1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 AET40892.1 - 0.18 11.5 2.5 1.5 8.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 AET40892.1 - 0.19 11.5 0.0 0.19 11.5 0.0 3.1 2 1 0 2 2 1 0 AAA domain NACHT PF05729.12 AET40892.1 - 0.19 11.6 0.6 3.1 7.7 0.0 2.9 2 1 1 3 3 3 0 NACHT domain AAA_17 PF13207.6 AET40892.1 - 0.49 10.8 5.1 0.59 10.5 0.0 2.9 2 1 1 3 3 2 0 AAA domain GCR1_C PF12550.8 AET40893.1 - 1.2e-25 89.7 1.2 2.5e-25 88.6 1.2 1.6 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes IQCJ-SCHIP1 PF15157.6 AET40893.1 - 0.06 13.2 3.4 1 9.2 0.0 3.3 3 0 0 3 3 3 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif WD40 PF00400.32 AET40894.1 - 2.6e-56 186.3 20.1 2.1e-10 41.0 0.1 6.9 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 AET40894.1 - 1.5e-41 141.7 1.7 2.4e-41 141.0 1.7 1.4 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 AET40894.1 - 1.3e-16 60.6 0.1 0.28 11.5 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AET40894.1 - 2.3e-07 30.4 0.0 0.002 17.5 0.0 3.7 4 0 0 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 AET40894.1 - 2.7e-06 26.6 0.1 0.26 10.2 0.0 3.6 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein LisH PF08513.11 AET40894.1 - 8.5e-06 25.5 0.0 1.8e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 LisH Nup160 PF11715.8 AET40894.1 - 9.3e-05 21.3 1.5 0.05 12.3 0.1 3.6 3 2 3 6 6 6 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 AET40894.1 - 0.035 12.6 0.2 1.1 7.7 0.1 2.5 1 1 0 2 2 2 0 Cytochrome D1 heme domain PD40 PF07676.12 AET40894.1 - 0.079 12.9 0.2 20 5.3 0.0 3.2 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat nos_propeller PF18764.1 AET40894.1 - 0.11 12.4 0.0 26 4.8 0.0 3.3 3 0 0 3 3 3 0 Nitrous oxide reductase propeller repeat Rep_Org_C PF06926.11 AET40894.1 - 0.16 12.3 0.2 0.34 11.2 0.2 1.5 1 0 0 1 1 1 0 Putative replisome organiser protein C-terminus GPI2 PF06432.11 AET40895.1 - 9e-54 182.8 28.8 3.3e-53 181.0 28.8 1.7 1 1 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase DUF5315 PF17242.2 AET40896.1 - 7.7e-25 86.5 0.2 1.2e-24 86.0 0.2 1.3 1 0 0 1 1 1 1 Disordered region of unknown function (DUF5315) 4HB_MCP_1 PF12729.7 AET40896.1 - 0.029 13.9 0.4 0.034 13.7 0.4 1.2 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction PGI PF00342.19 AET40897.1 - 7.4e-241 799.9 2.2 8.5e-241 799.7 2.2 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase CAF1C_H4-bd PF12265.8 AET40898.1 - 1.1e-17 64.0 1.3 2e-17 63.2 0.5 2.0 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 AET40898.1 - 5e-12 46.1 20.9 0.001 19.9 2.9 5.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET40898.1 - 1.1e-06 28.8 1.5 0.25 11.7 0.0 4.5 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Mt_ATP-synt_B PF05405.14 AET40899.1 - 2.9e-52 176.6 8.2 3.5e-52 176.3 8.2 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) rve_3 PF13683.6 AET40899.1 - 0.11 12.3 0.3 0.59 10.0 0.0 2.1 2 0 0 2 2 2 0 Integrase core domain DUF5623 PF18536.1 AET40899.1 - 0.24 11.7 1.5 0.95 9.8 0.4 2.1 1 1 2 3 3 3 0 Domain of unknown function (DUF5623) Med8 PF10232.9 AET40900.1 - 6.7e-16 58.6 0.1 7.9e-16 58.4 0.1 1.2 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 G10 PF01125.17 AET40900.1 - 0.029 14.1 0.0 0.13 12.0 0.0 1.8 2 0 0 2 2 2 0 G10 protein NPV_P10 PF05531.12 AET40900.1 - 0.053 14.0 0.3 0.46 11.0 0.3 2.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DASH_Hsk3 PF08227.11 AET40900.1 - 0.14 12.6 4.0 0.44 11.0 1.6 2.4 2 1 0 2 2 2 0 DASH complex subunit Hsk3 like Mito_carr PF00153.27 AET40901.1 - 5.4e-76 250.6 0.6 1.1e-26 92.6 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 AET40901.1 - 0.0012 18.0 0.7 3.1 6.9 0.0 3.8 1 1 2 4 4 4 3 Gammaproteobacterial serine protease Ribosomal_L21e PF01157.18 AET40902.1 - 7.5e-48 160.6 4.9 7.5e-48 160.6 4.9 1.6 2 0 0 2 2 2 1 Ribosomal protein L21e LRS4 PF10422.9 AET40902.1 - 0.00083 19.0 0.1 0.00099 18.8 0.1 1.1 1 0 0 1 1 1 1 Monopolin complex subunit LRS4 SIMPL PF04402.14 AET40902.1 - 0.02 15.3 0.0 0.025 15.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF541) MarR_2 PF12802.7 AET40902.1 - 0.17 11.8 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 MarR family S4 PF01479.25 AET40903.1 - 9.2e-13 47.7 1.7 1.1e-12 47.4 0.2 2.0 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 AET40903.1 - 6.7e-05 23.7 0.3 0.00011 23.1 0.2 1.4 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain DUF3535 PF12054.8 AET40904.1 - 4.6e-117 391.9 8.5 5.7e-117 391.6 2.1 3.9 5 0 0 5 5 5 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 AET40904.1 - 8.8e-67 225.3 0.0 1.6e-66 224.4 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AET40904.1 - 2e-18 66.7 0.0 1e-17 64.5 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HEAT PF02985.22 AET40904.1 - 5.1e-16 57.4 1.8 0.56 10.6 0.0 9.1 9 0 0 9 9 7 4 HEAT repeat Vac14_Fab1_bd PF12755.7 AET40904.1 - 1.4e-07 32.0 0.2 0.39 11.3 0.0 5.3 4 1 1 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 AET40904.1 - 1.3e-05 25.5 0.7 2.7 8.4 0.0 6.6 5 3 2 8 8 8 1 HEAT repeats HEAT_EZ PF13513.6 AET40904.1 - 1.7e-05 25.2 9.2 3 8.5 0.0 8.0 9 1 0 9 9 9 1 HEAT-like repeat ResIII PF04851.15 AET40904.1 - 8.5e-05 22.6 0.0 0.012 15.7 0.0 3.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 AET40904.1 - 0.0053 16.0 0.0 0.016 14.4 0.0 1.8 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase TAF6_C PF07571.13 AET40904.1 - 0.069 13.5 0.1 4.9 7.5 0.0 4.1 3 0 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain TAFH PF07531.14 AET40904.1 - 1.1 9.4 3.8 7.3 6.8 0.1 3.7 3 0 0 3 3 3 0 NHR1 homology to TAF NOA36 PF06524.12 AET40904.1 - 5.7 6.2 11.2 13 5.0 11.2 1.5 1 0 0 1 1 1 0 NOA36 protein cwf18 PF08315.12 AET40905.1 - 1.3e-21 77.7 5.4 1.5e-21 77.4 5.4 1.1 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor DUF1492 PF07374.11 AET40905.1 - 0.021 15.0 0.3 0.053 13.7 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1492) Mac PF12464.8 AET40905.1 - 2.2 8.6 4.1 1.6 9.0 0.6 2.3 2 1 0 2 2 2 0 Maltose acetyltransferase UPF0016 PF01169.19 AET40906.1 - 1.4e-40 137.4 22.5 4.7e-21 74.9 6.2 2.2 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 OFeT_1 PF16955.5 AET40906.1 - 0.0018 18.0 2.0 0.0026 17.5 0.1 1.9 2 0 0 2 2 2 1 Ferrous iron uptake permease, iron-lead transporter LysE PF01810.18 AET40906.1 - 0.0045 16.5 12.0 0.021 14.3 2.8 2.6 2 1 0 2 2 2 2 LysE type translocator DUF308 PF03729.13 AET40906.1 - 0.11 12.9 12.2 1.3 9.4 4.2 2.9 2 1 0 2 2 2 0 Short repeat of unknown function (DUF308) DUF4131 PF13567.6 AET40906.1 - 0.76 9.4 2.8 7.7 6.1 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) DUF2627 PF11118.8 AET40906.1 - 0.88 10.2 4.3 2.1 9.0 1.5 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2627) AAA PF00004.29 AET40907.1 - 2.1e-32 112.3 0.0 3.9e-32 111.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AET40907.1 - 2.5e-08 34.3 0.0 8.5e-08 32.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AET40907.1 - 3.9e-07 30.6 0.3 4.4e-06 27.2 0.1 2.5 2 1 0 2 2 1 1 AAA ATPase domain AAA_30 PF13604.6 AET40907.1 - 2e-05 24.4 0.0 3.3e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 AET40907.1 - 5e-05 23.2 0.0 0.00015 21.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AET40907.1 - 6e-05 23.4 0.3 0.014 15.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 AET40907.1 - 0.00014 21.9 0.3 0.00063 19.8 0.3 2.2 1 1 0 1 1 1 1 AAA domain DUF1633 PF07794.11 AET40907.1 - 0.00019 19.8 0.0 0.00039 18.8 0.0 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1633) AAA_18 PF13238.6 AET40907.1 - 0.00026 21.5 1.5 0.0008 20.0 0.1 2.8 3 2 1 4 4 3 1 AAA domain Rad17 PF03215.15 AET40907.1 - 0.00053 20.0 0.0 0.0019 18.2 0.0 1.9 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_24 PF13479.6 AET40907.1 - 0.00063 19.5 0.0 0.0012 18.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AET40907.1 - 0.0012 19.0 0.1 0.0023 18.1 0.1 1.6 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 AET40907.1 - 0.0012 19.2 0.0 0.005 17.2 0.0 2.1 1 0 0 1 1 1 1 RNA helicase NACHT PF05729.12 AET40907.1 - 0.0012 18.7 0.2 0.0033 17.4 0.2 1.9 1 1 0 1 1 1 1 NACHT domain ABC_tran PF00005.27 AET40907.1 - 0.0013 19.2 0.4 0.0051 17.3 0.0 2.1 2 1 0 2 2 2 1 ABC transporter ATPase_2 PF01637.18 AET40907.1 - 0.0028 17.6 0.3 3.2 7.6 0.2 2.8 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_5 PF07728.14 AET40907.1 - 0.0035 17.3 1.1 0.11 12.5 0.1 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 AET40907.1 - 0.004 16.7 0.0 0.015 14.9 0.0 2.0 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF2075 PF09848.9 AET40907.1 - 0.0074 15.6 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 AET40907.1 - 0.008 16.1 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 NTPase RuvB_N PF05496.12 AET40907.1 - 0.0097 15.7 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_23 PF13476.6 AET40907.1 - 0.016 15.7 1.7 0.016 15.7 1.7 2.5 2 1 0 2 2 2 0 AAA domain AAA_17 PF13207.6 AET40907.1 - 0.017 15.6 0.9 0.082 13.3 0.1 2.5 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 AET40907.1 - 0.018 14.8 0.1 0.064 13.0 0.0 2.0 2 0 0 2 2 1 0 Cytidylate kinase TsaE PF02367.17 AET40907.1 - 0.022 14.8 0.0 0.046 13.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TniB PF05621.11 AET40907.1 - 0.026 14.0 0.0 0.1 12.0 0.0 2.0 1 1 0 1 1 1 0 Bacterial TniB protein T2SSE PF00437.20 AET40907.1 - 0.026 13.6 0.0 0.058 12.4 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein Sigma54_activ_2 PF14532.6 AET40907.1 - 0.032 14.4 0.3 0.2 11.8 0.1 2.5 2 1 0 2 2 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 AET40907.1 - 0.04 13.7 0.0 0.093 12.5 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.6 AET40907.1 - 0.041 13.5 0.0 0.1 12.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 AET40907.1 - 0.047 13.7 0.1 0.55 10.2 0.1 2.5 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Mg_chelatase PF01078.21 AET40907.1 - 0.055 12.9 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 AET40907.1 - 0.056 12.8 0.1 0.7 9.2 0.0 2.2 2 0 0 2 2 2 0 KaiC Viral_helicase1 PF01443.18 AET40907.1 - 0.082 12.6 0.6 0.22 11.3 0.5 1.9 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.26 AET40907.1 - 0.083 12.6 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.6 AET40907.1 - 0.084 13.1 0.2 0.17 12.1 0.2 1.5 1 0 0 1 1 1 0 AAA domain MBA1 PF07961.11 AET40908.1 - 4.2e-99 330.4 0.0 5e-99 330.1 0.0 1.0 1 0 0 1 1 1 1 MBA1-like protein Glyco_transf_20 PF00982.21 AET40908.1 - 0.061 12.0 0.0 0.085 11.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 20 Sec16_C PF12931.7 AET40909.1 - 2e-71 241.1 0.1 3.4e-71 240.4 0.1 1.4 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 AET40909.1 - 3.9e-08 33.9 0.0 3.1e-07 31.0 0.0 2.7 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Sec16_N PF12935.7 AET40909.1 - 0.00018 21.8 25.0 0.00018 21.8 25.0 3.2 2 0 0 2 2 2 1 Vesicle coat trafficking protein Sec16 N-terminus PAC1 PF16094.5 AET40909.1 - 0.061 12.5 4.5 0.13 11.4 4.5 1.5 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 Nup96 PF12110.8 AET40909.1 - 0.062 12.4 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Nuclear protein 96 Cecropin PF00272.19 AET40909.1 - 0.63 9.8 2.1 16 5.3 0.3 2.4 2 0 0 2 2 2 0 Cecropin family Radical_SAM_C PF16199.5 AET40910.1 - 8.1e-33 112.3 0.0 1.6e-32 111.3 0.0 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 AET40910.1 - 9.7e-20 71.6 0.1 3.6e-19 69.8 0.1 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 AET40910.1 - 8.7e-10 38.9 0.1 1.6e-09 38.0 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AET40910.1 - 6.1e-06 26.2 0.0 1.4e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AET40910.1 - 0.022 15.2 0.0 0.047 14.1 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Beta_elim_lyase PF01212.21 AET40911.1 - 4.5e-52 177.1 0.0 5.7e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 AET40911.1 - 0.061 12.3 0.0 0.091 11.7 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Ceramidase PF05875.12 AET40912.1 - 1.3e-88 296.9 18.6 1.5e-88 296.6 18.6 1.0 1 0 0 1 1 1 1 Ceramidase DUF2391 PF09622.10 AET40912.1 - 0.035 13.4 0.3 0.064 12.6 0.3 1.4 1 0 0 1 1 1 0 Putative integral membrane protein (DUF2391) SRF-TF PF00319.18 AET40913.1 - 3.3e-20 71.3 0.1 6.5e-20 70.4 0.1 1.5 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Ribosomal_S6e PF01092.19 AET40914.1 - 5.4e-58 194.4 0.3 1.1e-57 193.4 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e Pyr_redox_2 PF07992.14 AET40915.1 - 3e-58 197.4 0.4 4.4e-58 196.8 0.4 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 AET40915.1 - 4.1e-34 117.1 0.3 3.3e-33 114.2 0.2 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 AET40915.1 - 1.2e-17 64.2 2.3 9.8e-17 61.3 0.2 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AET40915.1 - 1.9e-13 50.3 3.2 1.6e-12 47.3 3.2 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 AET40915.1 - 2.9e-06 26.9 0.0 4.5e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 AET40915.1 - 7.9e-06 25.2 0.0 1.2e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 AET40915.1 - 0.00028 20.1 3.1 0.00094 18.4 0.5 2.7 3 0 0 3 3 3 1 Glucose inhibited division protein A HI0933_like PF03486.14 AET40915.1 - 0.00031 19.6 1.7 0.28 9.8 0.4 3.1 3 0 0 3 3 3 1 HI0933-like protein AlaDh_PNT_C PF01262.21 AET40915.1 - 0.003 16.9 0.2 0.96 8.7 0.0 2.4 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 AET40915.1 - 0.0077 15.6 0.2 0.64 9.4 0.0 2.9 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 AET40915.1 - 0.021 14.1 2.0 1.4 8.1 0.1 2.3 2 0 0 2 2 2 0 FAD binding domain ApbA PF02558.16 AET40915.1 - 0.024 14.3 0.1 0.043 13.4 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.23 AET40915.1 - 0.23 11.4 0.8 0.32 11.0 0.0 1.7 2 0 0 2 2 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 AET40915.1 - 0.28 11.1 0.0 0.28 11.1 0.0 2.1 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 AET40915.1 - 0.31 10.1 3.6 0.25 10.4 1.6 1.8 2 0 0 2 2 2 0 FAD binding domain MFS_1 PF07690.16 AET40916.1 - 9.5e-44 149.8 23.9 1.4e-43 149.2 23.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AET40916.1 - 2.4e-16 59.6 24.2 1e-13 51.0 2.3 3.2 2 1 0 2 2 2 2 Sugar (and other) transporter NOG1_N PF17835.1 AET40917.1 - 1.5e-50 171.3 2.1 1.8e-50 171.0 0.1 2.2 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOGCT PF08155.11 AET40917.1 - 7.8e-26 89.8 2.0 1.9e-25 88.6 2.0 1.7 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 AET40917.1 - 4.4e-25 87.2 0.1 3.9e-24 84.2 0.2 2.5 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 AET40917.1 - 9.4e-16 57.9 0.0 2.1e-15 56.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AET40917.1 - 4.9e-08 32.7 0.0 1.1e-07 31.5 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 AET40917.1 - 0.0011 18.4 0.2 0.0019 17.6 0.2 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Dynamin_N PF00350.23 AET40917.1 - 0.048 13.7 0.0 10 6.1 0.0 2.8 1 1 1 2 2 2 0 Dynamin family AAA_16 PF13191.6 AET40917.1 - 0.049 14.0 0.0 0.14 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 AET40917.1 - 0.5 10.8 6.4 5 7.6 6.4 2.6 1 1 0 1 1 1 0 AAA domain Sec62 PF03839.16 AET40918.1 - 4.5e-72 242.1 0.1 5.7e-72 241.7 0.1 1.0 1 0 0 1 1 1 1 Translocation protein Sec62 Dynamin_N PF00350.23 AET40919.1 - 2.8e-17 63.3 0.2 2.8e-17 63.3 0.2 1.9 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 AET40919.1 - 6.5e-11 42.3 0.3 5.5e-10 39.3 0.1 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AET40919.1 - 1e-09 38.2 0.7 1.4e-08 34.5 0.5 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain cobW PF02492.19 AET40919.1 - 0.00014 21.5 0.4 0.021 14.4 0.3 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 AET40919.1 - 0.003 17.3 0.3 3.1 7.5 0.2 2.6 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 AET40919.1 - 0.014 15.9 0.0 0.18 12.4 0.0 2.8 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 AET40919.1 - 0.022 14.8 0.1 0.092 12.7 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TniB PF05621.11 AET40919.1 - 0.047 13.1 0.1 0.21 11.0 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein AAA_29 PF13555.6 AET40919.1 - 0.065 13.0 0.0 0.21 11.4 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain FeoB_N PF02421.18 AET40919.1 - 0.086 12.4 1.2 9.7 5.7 0.0 3.0 3 0 0 3 3 3 0 Ferrous iron transport protein B Abhydrolase_1 PF00561.20 AET40920.1 - 9.5e-19 68.0 0.0 6.5e-18 65.3 0.0 2.1 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AET40920.1 - 2.2e-07 30.4 0.0 6.5e-07 28.9 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 AET40920.1 - 0.0023 18.6 0.0 0.0042 17.7 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 AET40920.1 - 0.16 12.1 0.0 0.34 11.1 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein Rad4 PF03835.15 AET40921.1 - 6.7e-14 51.8 1.6 6.7e-14 51.8 1.6 1.6 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 AET40921.1 - 3.5e-10 40.3 0.1 6.7e-10 39.4 0.1 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily PAW PF04721.17 AET40921.1 - 0.071 12.9 1.4 0.17 11.7 1.4 1.7 1 0 0 1 1 1 0 PNGase C-terminal domain, mannose-binding module PAW zf-TFIIB PF13453.6 AET40921.1 - 0.37 10.2 7.0 0.31 10.4 3.1 2.6 3 0 0 3 3 3 0 Transcription factor zinc-finger tRNA-synt_1b PF00579.25 AET40922.1 - 9.8e-73 245.0 0.0 1.4e-72 244.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 AET40922.1 - 0.0086 15.9 0.8 0.16 11.8 0.8 2.3 1 1 0 1 1 1 1 Tyrosyl-tRNA synthetase C-terminal domain Romo1 PF10247.9 AET40923.1 - 6.6e-29 100.1 9.0 8.4e-29 99.7 9.0 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Nucleoporin_N PF08801.11 AET40925.1 - 3.5e-09 35.9 0.2 0.033 13.0 0.0 3.3 1 1 2 3 3 3 3 Nup133 N terminal like WD40 PF00400.32 AET40925.1 - 4.4e-05 24.2 0.1 0.019 15.9 0.0 3.3 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET40925.1 - 0.00011 22.5 0.0 1.3 9.3 0.0 3.7 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Plasmod_Pvs28 PF06247.11 AET40925.1 - 4.7 7.6 6.8 29 5.1 0.5 3.3 3 0 0 3 3 3 0 Pvs28 EGF domain PAXNEB PF05625.11 AET40926.1 - 6.2e-89 298.7 0.5 7.3e-89 298.5 0.5 1.1 1 0 0 1 1 1 1 PAXNEB protein GNAT_acetyltran PF12746.7 AET40926.1 - 0.16 11.5 0.0 1.2 8.7 0.0 1.9 2 0 0 2 2 2 0 GNAT acetyltransferase Lactamase_B_2 PF12706.7 AET40927.1 - 4.9e-31 107.8 0.0 7.3e-31 107.2 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AET40927.1 - 3.1e-13 49.9 0.0 6.1e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 AET40927.1 - 0.053 13.5 0.9 0.11 12.5 0.3 1.8 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily Pantoate_transf PF02548.15 AET40928.1 - 1.7e-92 309.5 0.0 2e-92 309.3 0.0 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 AET40928.1 - 0.0042 16.6 0.1 0.0086 15.6 0.0 1.5 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase YmzC PF14157.6 AET40928.1 - 0.12 12.4 0.1 0.29 11.2 0.1 1.6 1 1 0 1 1 1 0 YmzC-like protein Abhydrolase_1 PF00561.20 AET40929.1 - 6.7e-17 62.0 0.0 1.5e-16 60.8 0.0 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AET40929.1 - 4.1e-13 50.4 0.0 4.9e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AET40929.1 - 1.4e-10 40.8 0.0 3.4e-10 39.6 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 AET40929.1 - 3.4e-05 24.1 0.0 7.5e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_3 PF07859.13 AET40929.1 - 0.0007 19.5 0.0 0.001 19.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 AET40929.1 - 0.0011 18.7 0.0 0.0028 17.4 0.0 1.7 1 1 0 1 1 1 1 Putative esterase PGAP1 PF07819.13 AET40929.1 - 0.0012 18.7 0.1 0.024 14.3 0.1 2.2 1 1 0 1 1 1 1 PGAP1-like protein DUF915 PF06028.11 AET40929.1 - 0.014 14.7 1.1 0.06 12.7 0.1 2.4 2 1 1 3 3 3 0 Alpha/beta hydrolase of unknown function (DUF915) PAF-AH_p_II PF03403.13 AET40929.1 - 0.015 13.8 0.1 4.3 5.8 0.0 3.0 2 1 1 3 3 3 0 Platelet-activating factor acetylhydrolase, isoform II DLH PF01738.18 AET40929.1 - 0.019 14.5 0.0 0.084 12.4 0.0 2.0 2 1 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 AET40929.1 - 0.024 14.4 0.0 0.36 10.6 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Lipase_2 PF01674.18 AET40929.1 - 0.026 14.1 0.0 0.048 13.2 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 2) DUF2048 PF09752.9 AET40929.1 - 0.027 13.6 0.0 0.074 12.1 0.1 1.3 1 1 0 1 1 1 0 Abhydrolase domain containing 18 Ndr PF03096.14 AET40929.1 - 0.12 11.0 0.0 0.23 10.1 0.0 1.4 1 0 0 1 1 1 0 Ndr family Palm_thioest PF02089.15 AET40929.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF676 PF05057.14 AET40929.1 - 0.14 11.7 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) tRNA-synt_2 PF00152.20 AET40930.1 - 1.2e-94 316.9 0.0 1.6e-94 316.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AET40930.1 - 7.6e-06 25.8 0.2 1.4e-05 24.9 0.2 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2b PF00587.25 AET40930.1 - 0.0044 17.0 0.0 0.0082 16.1 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.20 AET40930.1 - 0.15 11.5 0.1 1 8.8 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) WD40 PF00400.32 AET40931.1 - 3.3e-21 75.2 16.9 3.7e-05 24.4 0.3 6.6 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET40931.1 - 6e-17 61.7 0.1 1.3e-06 28.6 0.0 4.9 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AET40931.1 - 0.00062 18.5 0.1 6.2 5.3 0.0 3.9 1 1 3 4 4 4 2 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 AET40931.1 - 0.00094 18.3 0.0 0.036 13.1 0.0 2.2 2 1 0 2 2 2 1 Coatomer WD associated region eIF2A PF08662.11 AET40931.1 - 0.0091 15.9 0.0 1.2 9.0 0.0 3.1 2 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A PQQ_3 PF13570.6 AET40931.1 - 0.021 15.3 0.0 0.35 11.4 0.0 2.7 2 0 0 2 2 2 0 PQQ-like domain WD40_like PF17005.5 AET40931.1 - 0.04 13.2 0.6 0.2 10.9 0.0 2.1 2 1 1 3 3 3 0 WD40-like domain UMP1 PF05348.11 AET40932.1 - 4.5e-41 139.8 0.0 5.3e-41 139.6 0.0 1.0 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 IIGP PF05049.13 AET40932.1 - 0.028 13.5 0.0 0.033 13.3 0.0 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) GYF PF02213.16 AET40933.1 - 1.3e-10 40.8 1.2 2.8e-10 39.7 1.2 1.5 1 0 0 1 1 1 1 GYF domain Sec66 PF09802.9 AET40934.1 - 1.6e-71 239.6 0.7 1.9e-71 239.4 0.7 1.1 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 Oxidored_q5_N PF01059.17 AET40934.1 - 0.012 15.6 0.0 0.02 15.0 0.0 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus Adeno_E3_CR2 PF02439.15 AET40934.1 - 0.047 13.5 0.1 0.069 12.9 0.1 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 CdvA PF18822.1 AET40934.1 - 0.061 13.2 1.0 0.09 12.6 1.0 1.3 1 0 0 1 1 1 0 CdvA-like coiled-coil domain NPL4 PF05021.15 AET40935.1 - 1.5e-131 438.3 0.0 2e-131 438.0 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 AET40935.1 - 5.1e-67 224.5 0.8 9.6e-67 223.6 0.8 1.5 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 AET40935.1 - 0.00048 20.6 0.1 0.0021 18.5 0.0 2.2 1 1 1 2 2 2 1 Nuclear pore localisation protein NPL4 Sulfate_transp PF00916.20 AET40936.1 - 1.8e-72 244.2 14.0 2.4e-72 243.8 14.0 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 AET40936.1 - 2e-17 62.9 0.0 3.4e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 STAS domain HopW1-1 PF15457.6 AET40936.1 - 0.17 11.1 0.0 0.27 10.5 0.0 1.2 1 0 0 1 1 1 0 Type III T3SS secreted effector HopW1-1/HopPmaA MFS_MOT1 PF16983.5 AET40936.1 - 1.9 8.9 20.2 0.47 10.9 2.9 2.8 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily Oxidored-like PF09791.9 AET40937.1 - 8.9e-23 79.7 0.5 1.9e-22 78.7 0.5 1.6 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal Pex24p PF06398.11 AET40938.1 - 1.8e-40 139.1 10.1 2.2e-40 138.8 10.1 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Rpp20 PF12328.8 AET40939.1 - 4.2e-28 98.0 4.8 1.5e-26 93.0 4.8 2.0 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 AET40939.1 - 3.7e-11 42.7 1.3 3.9e-11 42.6 0.4 1.5 2 0 0 2 2 2 1 Alba Ribosomal_L18 PF17135.4 AET40939.1 - 0.013 14.9 0.2 0.016 14.6 0.2 1.1 1 0 0 1 1 1 0 Ribosomal protein 60S L18 and 50S L18e BAAT_C PF08840.11 AET40939.1 - 0.058 13.3 0.0 0.07 13.0 0.0 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Ureidogly_lyase PF04115.12 AET40941.1 - 2.3e-53 180.7 0.0 2.7e-53 180.5 0.0 1.0 1 0 0 1 1 1 1 Ureidoglycolate lyase CSF-1 PF05337.11 AET40941.1 - 0.066 13.3 0.1 0.1 12.7 0.1 1.3 1 0 0 1 1 1 0 Macrophage colony stimulating factor-1 (CSF-1) PDH PF02153.17 AET40942.1 - 1.5e-10 40.5 0.0 2.4e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.17 AET40942.1 - 7.1e-05 23.3 0.0 0.00016 22.2 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 AET40942.1 - 0.00017 21.8 0.0 0.00031 21.0 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 AET40942.1 - 0.00065 19.4 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 AET40942.1 - 0.00093 18.6 0.0 0.0019 17.6 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 AET40942.1 - 0.0015 18.6 0.0 0.003 17.6 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 AET40942.1 - 0.0033 17.3 0.0 0.0052 16.7 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 AET40942.1 - 0.0061 16.1 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Arf PF00025.21 AET40944.1 - 1.5e-76 255.7 0.1 1.7e-76 255.5 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 AET40944.1 - 1.7e-15 57.3 0.1 2.2e-15 56.9 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 AET40944.1 - 3.5e-11 43.0 0.0 4e-11 42.8 0.0 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 AET40944.1 - 4.3e-11 42.6 0.0 4.9e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 AET40944.1 - 6.3e-10 38.8 0.0 7.7e-10 38.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 AET40944.1 - 1.2e-09 37.9 0.3 5.9e-06 25.7 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 AET40944.1 - 7e-05 22.9 0.0 0.00014 21.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AET40944.1 - 0.00041 19.9 0.2 0.0037 16.8 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 AET40944.1 - 0.00043 20.8 0.5 0.0018 18.8 0.5 1.8 1 1 0 1 1 1 1 ABC transporter MeaB PF03308.16 AET40944.1 - 0.003 16.6 0.9 0.13 11.2 0.3 2.7 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 AET40944.1 - 0.055 14.0 0.1 0.11 13.1 0.1 1.6 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 AET40944.1 - 0.11 12.1 0.4 0.67 9.5 0.1 2.0 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 AET40944.1 - 0.14 12.0 0.1 8.2 6.3 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 AET40944.1 - 0.17 11.5 1.1 8.9 5.9 0.2 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC1 PF03109.16 AET40945.1 - 2.2e-18 66.5 0.0 5.5e-18 65.3 0.0 1.7 1 0 0 1 1 1 1 ABC1 family GDPD PF03009.17 AET40946.1 - 1e-75 254.8 0.0 4e-75 252.9 0.0 2.0 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 AET40946.1 - 1.5e-27 96.0 0.0 5.9e-13 49.2 0.0 3.9 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) SPX PF03105.19 AET40946.1 - 3.8e-18 66.6 24.3 4.6e-12 46.6 1.6 4.6 4 1 1 5 5 5 3 SPX domain Ank_3 PF13606.6 AET40946.1 - 7.7e-17 59.7 1.5 0.37 11.5 0.1 7.2 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 AET40946.1 - 6.2e-15 54.9 1.2 0.018 15.5 0.0 6.3 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 AET40946.1 - 1.1e-14 54.6 0.0 5.4e-05 23.7 0.0 4.9 2 2 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 AET40946.1 - 1.2e-14 54.1 0.0 0.0017 18.7 0.0 5.1 3 1 2 5 5 5 5 Ankyrin repeats (many copies) Arginase PF00491.21 AET40948.1 - 2.3e-73 247.1 0.0 2.7e-73 246.9 0.0 1.0 1 0 0 1 1 1 1 Arginase family SKG6 PF08693.10 AET40949.1 - 1.1e-05 24.8 1.4 1.6e-05 24.2 1.4 1.2 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM154 PF15102.6 AET40949.1 - 0.0091 15.9 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 TMEM154 protein family Endomucin PF07010.12 AET40949.1 - 0.024 14.6 0.0 0.028 14.4 0.0 1.1 1 0 0 1 1 1 0 Endomucin Mid2 PF04478.12 AET40949.1 - 0.061 13.2 0.0 0.083 12.7 0.0 1.2 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF4448 PF14610.6 AET40949.1 - 0.069 12.9 0.0 0.092 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) SSPI PF14098.6 AET40949.1 - 0.12 12.6 0.3 0.2 11.9 0.3 1.4 1 1 0 1 1 1 0 Small, acid-soluble spore protein I DUF3827 PF12877.7 AET40949.1 - 0.13 10.6 0.0 0.16 10.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) 7tm_1 PF00001.21 AET40949.1 - 0.13 11.6 0.0 0.13 11.6 0.0 1.0 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Insulin_TMD PF17870.1 AET40949.1 - 0.27 11.3 1.1 0.35 11.0 0.1 1.7 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment FixS PF03597.15 AET40949.1 - 0.42 10.4 2.5 0.74 9.6 2.5 1.4 1 1 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type FeoB_associated PF12669.7 AET40949.1 - 6.1 7.3 5.5 0.61 10.5 0.4 1.8 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein PEX11 PF05648.14 AET40950.1 - 6.5e-06 25.8 6.2 0.0025 17.3 1.5 2.7 3 1 0 3 3 3 2 Peroxisomal biogenesis factor 11 (PEX11) Rab5-bind PF09311.11 AET40950.1 - 0.062 12.7 1.3 0.099 12.0 1.3 1.2 1 0 0 1 1 1 0 Rabaptin-like protein 2-Hacid_dh_C PF02826.19 AET40951.1 - 1.5e-34 118.9 0.0 2.8e-34 118.0 0.0 1.4 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TFIIA PF03153.13 AET40952.1 - 1.1e-51 177.2 18.9 5.6e-29 102.4 14.4 2.0 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit Fungal_TACC PF12709.7 AET40953.1 - 4.2e-32 110.4 15.1 4.2e-32 110.4 15.1 8.4 3 1 4 7 7 7 1 Fungal Transforming acidic coiled-coil (TACC) proteins HAP1_N PF04849.13 AET40953.1 - 0.00093 18.5 40.9 0.00093 18.5 40.9 4.9 1 1 3 5 5 5 1 HAP1 N-terminal conserved region Bcr-Abl_Oligo PF09036.10 AET40953.1 - 0.0041 17.1 0.9 0.0041 17.1 0.9 5.5 5 3 2 7 7 7 1 Bcr-Abl oncoprotein oligomerisation domain DUF724 PF05266.14 AET40953.1 - 0.0043 16.9 9.7 0.0043 16.9 9.7 6.1 1 1 3 6 6 6 2 Protein of unknown function (DUF724) SlyX PF04102.12 AET40953.1 - 0.01 16.4 7.3 0.01 16.4 7.3 9.3 6 3 3 9 9 9 0 SlyX GPHR_N PF12537.8 AET40953.1 - 0.62 10.2 2.8 15 5.7 0.2 3.6 2 0 0 2 2 2 0 The Golgi pH Regulator (GPHR) Family N-terminal DUF4407 PF14362.6 AET40953.1 - 0.89 8.8 73.0 0.87 8.9 4.9 5.1 1 1 4 5 5 5 0 Domain of unknown function (DUF4407) ATG16 PF08614.11 AET40953.1 - 2.6 8.2 103.7 0.025 14.8 35.1 5.9 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) RhoGAP PF00620.27 AET40954.1 - 8.7e-34 116.5 0.0 1.9e-33 115.4 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 AET40954.1 - 3e-08 34.1 0.1 7.1e-08 32.9 0.1 1.7 1 0 0 1 1 1 1 PH domain PX PF00787.24 AET40954.1 - 2.3e-05 24.3 0.0 5.1e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 PX domain DUF1708 PF08101.11 AET40954.1 - 0.00034 19.9 0.0 0.00072 18.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) LIAS_N PF16881.5 AET40955.1 - 1.5e-22 80.1 0.0 3e-22 79.1 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 AET40955.1 - 1.2e-11 45.3 0.0 2e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Spore_GerAC PF05504.11 AET40955.1 - 0.026 14.8 0.0 0.044 14.0 0.0 1.3 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal NIF PF03031.18 AET40956.1 - 7.5e-53 178.5 0.1 1.3e-52 177.7 0.1 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Sof1 PF04158.14 AET40957.1 - 6e-29 100.2 15.3 1.8e-28 98.6 15.3 1.9 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 AET40957.1 - 5.8e-24 83.9 6.7 1.6e-05 25.5 0.0 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET40957.1 - 7.8e-06 26.1 0.3 1.2 9.4 0.0 4.4 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AET40957.1 - 0.00065 18.8 0.3 0.72 8.8 0.1 3.1 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 AET40957.1 - 0.0055 16.7 1.1 3.9 7.6 0.0 3.7 4 1 1 5 5 5 2 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 AET40957.1 - 0.0069 15.8 0.2 0.036 13.4 0.1 2.2 3 0 0 3 3 3 1 WD40-like domain Abhydro_lipase PF04083.16 AET40958.1 - 1e-14 53.8 0.0 2.1e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 AET40958.1 - 3.7e-09 36.6 0.0 6.2e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AET40958.1 - 9.3e-05 21.8 0.0 0.00017 20.9 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Lipase_2 PF01674.18 AET40958.1 - 0.0083 15.7 0.0 0.019 14.5 0.0 1.6 1 1 0 1 1 1 1 Lipase (class 2) DUF900 PF05990.12 AET40958.1 - 0.025 14.1 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) POC3_POC4 PF10448.9 AET40959.1 - 3.5e-30 104.9 0.0 4e-30 104.7 0.0 1.0 1 0 0 1 1 1 1 20S proteasome chaperone assembly proteins 3 and 4 SBDS PF01172.18 AET40960.1 - 1.9e-32 111.2 0.4 3.5e-32 110.3 0.4 1.5 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 AET40960.1 - 3.7e-30 104.3 0.8 7.1e-30 103.4 0.8 1.5 1 0 0 1 1 1 1 SBDS protein C-terminal domain HlyIII PF03006.20 AET40961.1 - 5e-55 186.7 15.1 5e-55 186.7 15.1 1.4 2 0 0 2 2 2 1 Haemolysin-III related Saf_2TM PF18303.1 AET40961.1 - 1.5 8.4 3.5 1.6 8.3 0.4 2.3 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain PUF PF00806.19 AET40962.1 - 1.5e-53 175.5 13.2 7.9e-08 31.6 0.1 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat DUF2483 PF10656.9 AET40962.1 - 0.038 14.2 0.0 0.081 13.1 0.0 1.6 1 0 0 1 1 1 0 Hypothetical protein of unknown function (DUF2483) Membralin PF09746.9 AET40962.1 - 0.44 9.5 10.6 0.77 8.7 10.6 1.5 1 0 0 1 1 1 0 Tumour-associated protein FAM60A PF15396.6 AET40962.1 - 0.9 9.5 19.6 2.5 8.0 19.6 1.9 1 0 0 1 1 1 0 Protein Family FAM60A PAT1 PF09770.9 AET40962.1 - 2.6 6.2 46.2 5.3 5.2 46.2 1.5 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 LAP1C PF05609.12 AET40962.1 - 3.4 6.7 30.7 6.4 5.7 30.7 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Rab5ip PF07019.12 AET40963.1 - 9.1e-25 87.1 3.6 1.1e-24 86.8 3.6 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF383 PF04063.14 AET40964.1 - 1.3e-64 217.4 1.0 3e-63 213.0 0.2 2.6 2 1 1 3 3 3 1 Domain of unknown function (DUF383) DUF384 PF04064.13 AET40964.1 - 3e-22 78.2 0.2 3e-22 78.2 0.2 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF384) Adaptin_N PF01602.20 AET40964.1 - 0.0018 16.9 0.7 0.0032 16.1 0.7 1.5 1 0 0 1 1 1 1 Adaptin N terminal region TFIIF_alpha PF05793.12 AET40965.1 - 3.2e-09 35.9 0.4 3.2e-09 35.9 0.4 3.5 3 1 1 4 4 4 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Vac7 PF12751.7 AET40965.1 - 0.32 10.4 4.6 0.25 10.7 2.5 1.6 1 1 0 1 1 1 0 Vacuolar segregation subunit 7 tRNA-synt_1b PF00579.25 AET40966.1 - 1e-73 248.2 0.0 1.3e-73 247.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) zf-UBR PF02207.20 AET40967.1 - 2e-12 47.1 8.2 2e-12 47.1 8.2 2.9 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) zf-B_box PF00643.24 AET40967.1 - 0.011 15.9 6.4 0.049 13.8 6.4 2.2 1 0 0 1 1 1 0 B-box zinc finger PHD_Oberon PF07227.11 AET40967.1 - 4.3 7.2 14.9 4.3 7.2 1.8 2.8 2 0 0 2 2 2 0 PHD - plant homeodomain finger protein UCR_UQCRX_QCR9 PF05365.12 AET40968.1 - 1.2e-26 92.4 2.6 1.4e-26 92.1 2.6 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like DUF2976 PF11190.8 AET40968.1 - 0.026 14.3 0.2 0.03 14.1 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) T6SS_HCP PF05638.12 AET40968.1 - 0.028 14.8 0.0 0.032 14.6 0.0 1.1 1 0 0 1 1 1 0 Type VI secretion system effector, Hcp zf-Tim10_DDP PF02953.15 AET40969.1 - 2.9e-18 65.3 0.5 4.2e-18 64.7 0.5 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger NES_C_h PF18208.1 AET40969.1 - 0.029 14.7 0.3 0.043 14.1 0.3 1.2 1 0 0 1 1 1 0 Nicking enzyme C-terminal middle helical domain Myb_DNA-bind_6 PF13921.6 AET40969.1 - 0.19 12.0 0.5 21 5.4 0.2 2.2 1 1 0 2 2 2 0 Myb-like DNA-binding domain Glyco_hydro_65m PF03632.15 AET40970.1 - 9.9e-35 120.1 2.7 2.1e-32 112.4 0.3 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65N PF03636.15 AET40970.1 - 8.5e-16 58.3 0.7 1.2e-14 54.6 0.7 2.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65C PF03633.15 AET40970.1 - 0.00016 21.5 0.0 0.00084 19.2 0.0 2.2 2 0 0 2 2 2 1 Glycosyl hydrolase family 65, C-terminal domain ATP-synt_ab PF00006.25 AET40971.1 - 1.4e-71 240.5 0.0 2e-71 240.0 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 AET40971.1 - 2.5e-47 160.3 1.0 4.8e-47 159.4 1.0 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 AET40971.1 - 4.1e-17 62.5 1.9 1.3e-16 60.9 1.9 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Tex_N PF09371.10 AET40971.1 - 0.049 13.3 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 Tex-like protein N-terminal domain AAA_22 PF13401.6 AET40971.1 - 0.096 13.0 0.0 0.39 11.0 0.0 2.0 3 0 0 3 3 3 0 AAA domain Cyclin_C_2 PF16899.5 AET40972.1 - 4.3e-31 107.4 0.2 1.4e-28 99.4 0.0 2.5 2 0 0 2 2 2 2 Cyclin C-terminal domain Cyclin_N PF00134.23 AET40972.1 - 2.1e-09 37.2 0.5 5.5e-09 35.8 0.5 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain TFIIB PF00382.19 AET40972.1 - 0.0017 18.4 0.0 0.0059 16.6 0.0 1.9 2 0 0 2 2 2 1 Transcription factor TFIIB repeat BBP2_2 PF10082.9 AET40972.1 - 0.031 13.1 0.0 0.057 12.2 0.0 1.3 1 0 0 1 1 1 0 Putative beta-barrel porin 2 Peptidase_M41 PF01434.18 AET40973.1 - 1e-60 204.9 0.1 1.9e-60 204.0 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 AET40973.1 - 1.1e-40 139.1 0.0 4.6e-40 137.1 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AET40973.1 - 1e-06 28.4 0.0 3e-06 26.9 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 AET40973.1 - 1.4e-05 25.6 0.7 0.00023 21.6 0.3 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AET40973.1 - 5.9e-05 23.4 0.2 0.13 12.5 0.0 3.6 3 1 1 4 4 4 1 AAA domain TIP49 PF06068.13 AET40973.1 - 0.00053 19.3 0.0 0.0013 18.0 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 AET40973.1 - 0.0016 18.2 0.1 0.0081 15.9 0.0 2.2 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 AET40973.1 - 0.004 17.1 0.1 0.014 15.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 AET40973.1 - 0.0083 15.7 0.6 1 8.9 0.3 2.6 1 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 AET40973.1 - 0.025 14.3 0.0 0.045 13.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 AET40973.1 - 0.049 13.0 0.2 0.12 11.8 0.2 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 AET40973.1 - 0.067 13.4 0.0 0.17 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 AET40973.1 - 0.098 12.7 0.0 0.29 11.1 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 AET40973.1 - 0.11 13.0 0.2 0.35 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 AET40973.1 - 0.16 11.3 0.4 0.58 9.5 0.0 2.0 3 0 0 3 3 3 0 KaiC Cnd2 PF05786.14 AET40974.1 - 1.9e-135 453.4 47.4 4.8e-133 445.5 47.4 2.7 1 1 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 AET40974.1 - 0.00032 20.9 3.9 0.00066 19.9 0.0 3.0 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal FAD_binding_3 PF01494.19 AET40975.1 - 3.5e-17 62.7 0.0 1.1e-16 61.1 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain SE PF08491.10 AET40975.1 - 1.5e-05 24.2 0.1 0.0012 18.0 0.0 2.2 2 0 0 2 2 2 1 Squalene epoxidase NAD_binding_8 PF13450.6 AET40975.1 - 4.1e-05 23.7 0.1 9.5e-05 22.6 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 AET40975.1 - 5.4e-05 22.5 0.0 7.3e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 AET40975.1 - 5.6e-05 23.6 0.0 0.00014 22.3 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 AET40975.1 - 0.001 18.7 0.0 0.0047 16.6 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 AET40975.1 - 0.003 16.9 0.0 0.0051 16.1 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 AET40975.1 - 0.012 14.5 0.1 0.55 9.0 0.0 2.4 3 0 0 3 3 3 0 Tryptophan halogenase FAD_binding_2 PF00890.24 AET40975.1 - 0.013 14.6 0.0 0.019 14.1 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain 3HCDH_N PF02737.18 AET40975.1 - 0.015 15.2 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 AET40975.1 - 0.016 13.9 0.0 0.025 13.3 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein ApbA PF02558.16 AET40975.1 - 0.021 14.4 0.0 0.037 13.7 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.14 AET40975.1 - 0.081 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 AET40975.1 - 0.086 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 4HBT PF03061.22 AET40976.1 - 5.4e-06 26.7 0.0 8.1e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily ArfGap PF01412.18 AET40977.1 - 4.8e-34 116.9 0.5 1.1e-33 115.8 0.5 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Rox3 PF08633.10 AET40978.1 - 3.3e-39 135.3 0.1 4.2e-39 135.0 0.1 1.1 1 0 0 1 1 1 1 Rox3 mediator complex subunit RgpF PF05045.12 AET40978.1 - 0.079 11.7 0.2 0.12 11.1 0.2 1.2 1 0 0 1 1 1 0 Rhamnan synthesis protein F Ribosomal_L32e PF01655.18 AET40979.1 - 9.1e-47 157.9 2.2 1.1e-46 157.7 2.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 Motile_Sperm PF00635.26 AET40980.1 - 2.9e-25 88.2 0.2 6.7e-25 87.1 0.0 1.7 1 1 1 2 2 2 1 MSP (Major sperm protein) domain TMEM131_like PF12371.8 AET40980.1 - 0.0021 18.2 0.1 0.0045 17.2 0.1 1.5 1 0 0 1 1 1 1 Transmembrane protein 131-like DUF4693 PF15764.5 AET40980.1 - 0.019 14.6 0.0 0.024 14.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4693) ASH PF15780.5 AET40980.1 - 0.038 14.2 0.1 0.078 13.2 0.1 1.5 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF5001 PF16392.5 AET40980.1 - 0.049 13.6 0.2 0.12 12.3 0.0 1.6 2 0 0 2 2 2 0 Ig-like domain Peptidase_M24 PF00557.24 AET40981.1 - 3.9e-49 167.2 0.0 5.2e-49 166.8 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 RPN2_C PF18004.1 AET40981.1 - 0.28 11.1 6.0 0.46 10.4 6.0 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Ribosomal_S21 PF01165.20 AET40982.1 - 3.6e-11 42.6 0.6 6.6e-11 41.8 0.6 1.5 1 0 0 1 1 1 1 Ribosomal protein S21 Ysc84 PF04366.12 AET40982.1 - 0.12 12.1 0.0 0.34 10.7 0.0 1.7 1 1 1 2 2 2 0 Las17-binding protein actin regulator Aa_trans PF01490.18 AET40983.1 - 4.1e-102 341.9 28.0 4.7e-102 341.7 28.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Wzy_C PF04932.15 AET40983.1 - 0.46 10.1 0.0 0.46 10.1 0.0 3.4 3 2 1 4 4 4 0 O-Antigen ligase SH3_1 PF00018.28 AET40984.1 - 2.1e-11 43.2 0.1 3.6e-11 42.5 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AET40984.1 - 3.5e-11 42.8 0.1 6.2e-11 42.0 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AET40984.1 - 3.3e-08 33.1 0.0 5.9e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Ribosomal_L14 PF00238.19 AET40985.1 - 7.8e-33 113.1 0.0 9.3e-33 112.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e zf-C3HC4 PF00097.25 AET40986.1 - 1.8e-10 40.5 5.2 2.8e-10 39.9 5.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AET40986.1 - 1.7e-09 37.4 4.9 2.4e-09 36.9 4.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AET40986.1 - 3.7e-08 33.3 3.9 6.5e-08 32.5 3.9 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 AET40986.1 - 4.1e-07 29.9 6.0 6.3e-07 29.3 6.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 AET40986.1 - 2.3e-06 27.9 5.9 3.6e-06 27.2 5.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 AET40986.1 - 1.2e-05 25.1 7.1 2.9e-05 23.8 7.3 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AET40986.1 - 3.6e-05 23.5 4.2 0.00019 21.2 4.7 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 AET40986.1 - 0.004 17.3 7.5 0.007 16.5 7.5 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING FBP_C PF16571.5 AET40986.1 - 0.014 14.9 0.2 0.024 14.2 0.2 1.4 1 0 0 1 1 1 0 FBP C-terminal treble-clef zinc-finger zf-ANAPC11 PF12861.7 AET40986.1 - 0.099 12.7 2.3 0.16 12.0 2.3 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 AET40986.1 - 0.12 12.2 5.6 0.87 9.4 0.5 3.2 3 0 0 3 3 3 0 RING-like zinc finger zf-rbx1 PF12678.7 AET40986.1 - 0.3 11.4 3.3 0.66 10.3 3.3 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 AET40986.1 - 0.46 10.3 7.0 6.7 6.6 7.7 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain NT-C2 PF10358.9 AET40988.1 - 6e-42 142.8 0.9 4.5e-41 140.0 1.1 2.0 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins NAGPA PF09992.9 AET40989.1 - 0.0057 16.9 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 Phosphodiester glycosidase PH PF00169.29 AET40990.1 - 3.1e-17 63.0 0.0 7.2e-17 61.8 0.0 1.6 1 0 0 1 1 1 1 PH domain SAM_2 PF07647.17 AET40990.1 - 2.5e-12 46.7 0.0 4.1e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_1 PF00018.28 AET40990.1 - 9.7e-12 44.3 0.2 2.4e-11 43.1 0.2 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AET40990.1 - 1.9e-08 34.0 0.1 3.8e-08 33.1 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_1 PF00536.30 AET40990.1 - 3.7e-05 24.1 0.0 6.3e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_8 PF15409.6 AET40990.1 - 7.7e-05 22.9 0.0 0.0024 18.1 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 AET40990.1 - 0.0015 18.9 0.2 0.015 15.7 0.2 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain BORCS8 PF10167.9 AET40990.1 - 0.062 13.2 3.8 0.26 11.2 0.1 2.6 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 8 SH3_2 PF07653.17 AET40990.1 - 0.065 12.9 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain SAM_3 PF18016.1 AET40990.1 - 0.13 12.1 0.1 0.44 10.4 0.1 1.9 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 AET40990.1 - 0.16 12.0 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain TPR_2 PF07719.17 AET40991.1 - 3.3e-42 139.2 12.1 1.7e-07 30.8 0.1 10.2 10 0 0 10 10 10 7 Tetratricopeptide repeat ANAPC3 PF12895.7 AET40991.1 - 4.9e-35 119.6 23.0 1.1e-20 73.6 2.7 5.2 4 1 1 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 AET40991.1 - 1.8e-34 116.1 22.8 4.2e-08 32.7 0.1 9.2 10 0 0 10 10 9 6 Tetratricopeptide repeat TPR_8 PF13181.6 AET40991.1 - 2.4e-31 105.3 7.2 6.9e-05 22.8 0.4 8.7 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_11 PF13414.6 AET40991.1 - 3.3e-25 87.5 15.5 6.5e-06 25.7 0.2 7.6 2 1 6 8 8 8 5 TPR repeat TPR_12 PF13424.6 AET40991.1 - 2.9e-19 69.1 10.4 0.0002 21.6 0.5 8.2 7 1 0 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 AET40991.1 - 1e-18 66.3 19.9 7.1e-05 22.9 0.4 8.5 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 AET40991.1 - 2e-18 66.8 0.4 4.3e-05 24.1 0.0 6.2 5 2 2 7 7 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 AET40991.1 - 4.3e-18 64.5 4.9 0.058 14.2 0.0 8.3 5 3 4 9 9 8 5 Tetratricopeptide repeat TPR_19 PF14559.6 AET40991.1 - 2.7e-16 59.8 2.1 4.9e-05 23.8 0.0 5.9 6 1 1 7 7 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 AET40991.1 - 1e-13 50.3 3.9 0.79 9.9 0.1 7.9 6 2 2 8 8 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 AET40991.1 - 1.1e-11 44.5 18.5 0.076 13.7 0.0 9.6 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_15 PF13429.6 AET40991.1 - 5.9e-11 42.1 0.4 0.0007 18.9 0.0 4.6 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 AET40991.1 - 4.7e-06 26.6 0.0 0.027 14.6 0.0 3.6 2 2 2 4 4 4 2 Tetratricopeptide repeat DUF3856 PF12968.7 AET40991.1 - 0.00024 21.2 0.4 0.65 10.1 0.1 4.7 3 1 1 4 4 3 1 Domain of Unknown Function (DUF3856) BTAD PF03704.17 AET40991.1 - 0.0015 19.0 0.0 0.7 10.3 0.0 2.9 2 1 1 3 3 2 1 Bacterial transcriptional activator domain TPR_4 PF07721.14 AET40991.1 - 0.0027 18.2 0.3 4.5 8.2 0.0 4.6 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 AET40991.1 - 0.0043 16.9 5.5 12 5.9 0.0 6.7 8 0 0 8 8 8 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 AET40991.1 - 0.013 15.5 2.2 0.21 11.6 0.0 3.5 3 1 0 3 3 3 0 Putative TPR-like repeat TPR_21 PF09976.9 AET40991.1 - 0.025 14.3 0.2 1.4 8.5 0.1 2.8 1 1 2 3 3 3 0 Tetratricopeptide repeat-like domain TPR_20 PF14561.6 AET40991.1 - 0.042 14.2 0.3 18 5.7 0.0 3.7 4 1 1 5 5 3 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 AET40991.1 - 0.048 13.3 0.0 63 3.2 0.0 3.7 1 1 2 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_3 PF07720.12 AET40991.1 - 0.086 12.9 16.4 1.4 9.0 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat Menin PF05053.13 AET40991.1 - 0.24 9.7 5.8 0.44 8.9 5.8 1.3 1 0 0 1 1 1 0 Menin IlvGEDA_leader PF08046.11 AET40991.1 - 0.32 10.5 0.9 0.66 9.5 0.9 1.5 1 0 0 1 1 1 0 IlvGEDA operon leader peptide PPR PF01535.20 AET40991.1 - 2.8 8.4 7.5 34 5.0 0.0 4.5 5 0 0 5 5 4 0 PPR repeat EMP70 PF02990.16 AET40992.1 - 2.8e-98 329.8 17.6 4.8e-98 329.1 17.6 1.4 1 1 0 1 1 1 1 Endomembrane protein 70 Sec62 PF03839.16 AET40992.1 - 0.31 10.5 3.4 0.67 9.4 3.4 1.5 1 0 0 1 1 1 0 Translocation protein Sec62 LSM PF01423.22 AET40993.1 - 7.1e-15 54.5 0.7 9.9e-15 54.0 0.7 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AET40993.1 - 0.00052 20.1 0.0 0.00083 19.4 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 AET40993.1 - 0.015 15.4 0.1 0.024 14.7 0.1 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain KilA-N PF04383.13 AET40994.1 - 6.4e-07 29.2 0.3 7.8e-06 25.7 0.3 2.7 1 1 0 1 1 1 1 KilA-N domain Ank_2 PF12796.7 AET40994.1 - 2e-06 28.3 0.4 0.17 12.5 0.0 2.7 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 AET40994.1 - 2.3e-05 24.8 1.7 0.013 16.1 0.2 3.9 2 1 2 4 4 4 1 Ankyrin repeats (many copies) Ank PF00023.30 AET40994.1 - 0.0045 17.4 2.2 1.5 9.4 0.2 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 AET40994.1 - 0.026 14.8 2.0 2 8.8 0.1 3.2 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 AET40994.1 - 0.053 14.1 5.4 1.4 9.7 0.1 4.2 5 0 0 5 5 5 0 Ankyrin repeat HEAT_EZ PF13513.6 AET40995.1 - 1.8e-16 60.2 0.1 0.0003 21.2 0.0 7.7 8 0 0 8 8 8 3 HEAT-like repeat IBN_N PF03810.19 AET40995.1 - 4.6e-13 48.9 8.0 5.1e-12 45.5 0.1 4.5 5 0 0 5 5 5 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 AET40995.1 - 9.6e-12 45.1 1.0 0.2 12.1 0.0 6.8 5 3 1 6 6 6 2 HEAT repeats HEAT PF02985.22 AET40995.1 - 2.4e-10 39.8 3.8 0.87 10.0 0.0 7.7 8 0 0 8 8 7 3 HEAT repeat Cnd1 PF12717.7 AET40995.1 - 1e-08 35.4 8.8 0.00065 19.8 0.6 5.4 5 2 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 AET40995.1 - 1.4e-07 32.0 4.5 13 6.4 0.0 6.8 5 2 2 7 7 7 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 AET40995.1 - 2.9e-05 23.8 3.0 1.4 8.4 0.0 5.0 5 0 0 5 5 5 2 CLASP N terminal DUF3385 PF11865.8 AET40995.1 - 0.00083 19.3 8.0 3.2 7.6 0.0 6.3 6 3 0 7 7 7 2 Domain of unknown function (DUF3385) RTP1_C1 PF10363.9 AET40995.1 - 0.01 16.0 0.9 2.7 8.2 0.1 4.1 3 1 1 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Ipi1_N PF12333.8 AET40995.1 - 0.22 12.1 0.9 97 3.6 0.0 4.8 6 0 0 6 6 5 0 Rix1 complex component involved in 60S ribosome maturation HEAT_PBS PF03130.16 AET40995.1 - 0.25 12.1 1.2 1e+02 4.0 0.0 4.9 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat ALG3 PF05208.13 AET40996.1 - 7.2e-127 423.7 29.2 9e-127 423.4 29.2 1.1 1 0 0 1 1 1 1 ALG3 protein LisH PF08513.11 AET40997.1 - 1.4e-07 31.2 0.3 2.2e-07 30.6 0.3 1.3 1 0 0 1 1 1 1 LisH WD40 PF00400.32 AET40998.1 - 2.5e-19 69.2 8.2 1.6e-05 25.5 0.4 4.8 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET40998.1 - 6.3e-10 39.2 0.0 0.025 14.9 0.0 4.6 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AET40998.1 - 8.2e-07 28.0 0.7 0.006 15.3 0.0 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 AET40998.1 - 0.00067 18.7 0.3 0.013 14.4 0.1 2.7 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 AET40998.1 - 0.0014 18.0 0.0 0.0027 17.1 0.0 1.5 1 0 0 1 1 1 1 WD40-like domain Frtz PF11768.8 AET40998.1 - 0.039 12.3 0.0 0.15 10.4 0.0 1.7 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF5349 PF17298.2 AET40999.1 - 7.4e-37 128.0 53.0 4.1e-36 125.5 53.0 1.8 1 1 0 1 1 1 1 Family of unknown function (DUF5349) GatB_N PF02934.15 AET41000.1 - 6e-90 301.3 0.0 7.5e-90 301.0 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 AET41000.1 - 2.4e-27 95.6 0.0 4e-27 94.9 0.0 1.4 1 0 0 1 1 1 1 GatB domain PUF PF00806.19 AET41001.1 - 3e-28 95.9 4.6 0.00011 21.7 0.0 7.2 7 0 0 7 7 7 6 Pumilio-family RNA binding repeat RRM_1 PF00076.22 AET41001.1 - 4.4e-07 29.6 0.0 1e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fip1 PF05182.13 AET41003.1 - 4.1e-22 77.4 0.5 4.1e-22 77.4 0.5 1.7 2 0 0 2 2 2 1 Fip1 motif DNA_pol_phi PF04931.13 AET41003.1 - 3 5.8 13.4 4.5 5.3 13.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi SUIM_assoc PF16619.5 AET41004.1 - 0.005 16.9 1.8 0.005 16.9 1.8 2.1 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Ribosomal_L37ae PF01780.19 AET41005.1 - 2.2e-40 136.6 8.9 2.5e-40 136.4 8.9 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 AET41005.1 - 0.0035 17.4 2.4 0.0066 16.6 2.4 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Zn_Tnp_IS1595 PF12760.7 AET41005.1 - 0.011 15.7 3.1 0.023 14.6 3.1 1.6 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Rep_fac-A_C PF08646.10 AET41005.1 - 0.013 15.3 0.4 0.015 15.0 0.4 1.2 1 0 0 1 1 1 0 Replication factor-A C terminal domain zf-H2C2_2 PF13465.6 AET41005.1 - 0.022 15.2 0.8 2.6 8.6 0.2 2.3 2 0 0 2 2 2 0 Zinc-finger double domain zf-ribbon_3 PF13248.6 AET41005.1 - 0.049 13.1 2.1 2 8.0 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain C1_2 PF03107.16 AET41005.1 - 0.055 13.8 2.8 0.77 10.1 3.0 2.1 1 1 1 2 2 2 0 C1 domain CarbpepA_inh PF02977.15 AET41005.1 - 0.1 12.4 3.0 0.65 9.8 3.0 2.2 1 1 0 1 1 1 0 Carboxypeptidase A inhibitor zf-C4_ClpX PF06689.13 AET41005.1 - 0.33 10.9 0.2 0.33 10.9 0.2 2.6 3 0 0 3 3 3 0 ClpX C4-type zinc finger Mito_carr PF00153.27 AET41006.1 - 6.5e-71 234.3 1.1 2.4e-23 81.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Aldo_ket_red PF00248.21 AET41008.1 - 2e-42 145.4 0.1 7.2e-40 137.0 0.1 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family PX PF00787.24 AET41009.1 - 2.3e-10 40.5 0.0 5.1e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 AET41009.1 - 0.0029 17.3 0.1 0.008 15.8 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 AET41009.1 - 0.0058 16.2 0.0 0.019 14.6 0.0 1.9 2 0 0 2 2 2 1 SH3 domain Peptidase_C12 PF01088.21 AET41010.1 - 2.8e-44 151.4 0.0 3.2e-44 151.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 SAC3_GANP PF03399.16 AET41011.1 - 2e-20 73.4 8.8 2.9e-18 66.3 8.8 2.4 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 AET41011.1 - 0.00089 19.3 0.6 0.0022 18.0 0.6 1.6 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Sod_Fe_C PF02777.18 AET41012.1 - 1.3e-13 50.9 1.5 8.5e-12 45.1 1.5 2.3 1 1 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain RecO_N_2 PF13114.6 AET41012.1 - 0.083 12.6 0.0 1.2 8.9 0.0 2.5 3 0 0 3 3 3 0 RecO N terminal ESCRT-II PF05871.12 AET41013.1 - 1e-38 132.8 1.1 1.3e-38 132.4 0.7 1.3 2 0 0 2 2 2 1 ESCRT-II complex subunit DUF2724 PF10893.8 AET41013.1 - 0.03 14.1 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2724) CTP_synth_N PF06418.14 AET41015.1 - 3.3e-124 413.5 0.1 4.5e-124 413.0 0.1 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 AET41015.1 - 2.6e-58 197.0 0.0 3.9e-58 196.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AET41015.1 - 0.022 14.5 0.1 0.24 11.1 0.1 2.3 1 1 0 1 1 1 0 Peptidase C26 CbiA PF01656.23 AET41015.1 - 0.12 12.5 0.0 0.59 10.2 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Sod_Cu PF00080.20 AET41016.1 - 5.3e-48 162.8 3.7 6.3e-48 162.6 3.7 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Thioredoxin PF00085.20 AET41017.1 - 5.5e-16 58.4 0.0 3.4e-12 46.3 0.0 2.8 3 0 0 3 3 3 2 Thioredoxin OST3_OST6 PF04756.13 AET41017.1 - 1.2e-06 28.1 0.0 1.9e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 AET41017.1 - 0.00049 20.4 0.0 0.072 13.4 0.0 3.2 2 1 1 3 3 3 1 Thioredoxin-like TraF PF13728.6 AET41017.1 - 0.00092 19.1 0.0 0.0019 18.0 0.0 1.4 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_2 PF13098.6 AET41017.1 - 0.047 14.1 0.1 6.4 7.3 0.0 3.1 2 1 0 2 2 2 0 Thioredoxin-like domain MtrB PF05440.12 AET41017.1 - 0.058 13.8 0.0 1.1 9.8 0.0 2.3 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase subunit B Thioredoxin_6 PF13848.6 AET41017.1 - 0.16 11.9 0.0 0.52 10.2 0.0 1.7 2 0 0 2 2 2 0 Thioredoxin-like domain ER_lumen_recept PF00810.18 AET41018.1 - 2.3e-49 168.0 12.2 2.3e-49 168.0 12.2 1.5 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.14 AET41018.1 - 0.036 13.8 0.6 0.036 13.8 0.6 3.3 4 0 0 4 4 4 0 PQ loop repeat Proteasome PF00227.26 AET41019.1 - 5.4e-38 130.4 0.1 3.1e-37 127.9 0.1 1.8 1 1 0 1 1 1 1 Proteasome subunit Peptidase_M20 PF01546.28 AET41020.1 - 1.9e-25 89.8 0.0 3e-25 89.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 AET41020.1 - 2.3e-10 40.3 0.0 4.9e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain AF-4 PF05110.13 AET41021.1 - 0.016 13.4 6.1 0.015 13.4 6.1 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein IMUP PF15761.5 AET41021.1 - 0.036 14.7 4.8 0.066 13.9 4.8 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein SDA1 PF05285.12 AET41021.1 - 7.3 5.9 12.4 7.1 5.9 11.7 1.3 1 1 0 1 1 1 0 SDA1 Peptidase_M16_C PF05193.21 AET41022.1 - 1.4e-21 77.4 0.0 3.4e-21 76.1 0.0 1.6 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 AET41022.1 - 2e-15 57.1 2.6 6.3e-15 55.5 2.6 1.8 1 1 0 1 1 1 1 Insulinase (Peptidase family M16) DUF3110 PF11360.8 AET41022.1 - 0.0044 17.2 0.1 0.017 15.3 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3110) EAP30 PF04157.16 AET41022.1 - 0.059 12.7 0.1 0.14 11.4 0.0 1.7 1 1 0 1 1 1 0 EAP30/Vps36 family PPP4R2 PF09184.11 AET41023.1 - 1.6e-47 162.5 14.0 1.6e-47 162.5 14.0 2.0 1 1 2 3 3 3 1 PPP4R2 SID-1_RNA_chan PF13965.6 AET41023.1 - 0.24 9.8 1.6 0.28 9.6 1.6 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TEX19 PF15553.6 AET41023.1 - 0.29 11.1 5.8 0.66 9.9 5.8 1.6 1 0 0 1 1 1 0 Testis-expressed protein 19 SDA1 PF05285.12 AET41023.1 - 0.32 10.4 17.2 0.39 10.1 17.2 1.3 1 0 0 1 1 1 0 SDA1 NOA36 PF06524.12 AET41023.1 - 0.93 8.8 21.9 1.6 8.0 21.9 1.4 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 AET41023.1 - 1.8 6.6 25.4 2.4 6.3 25.4 1.1 1 0 0 1 1 1 0 Nop14-like family YL1 PF05764.13 AET41023.1 - 5.4 7.1 17.4 8.7 6.4 17.4 1.4 1 0 0 1 1 1 0 YL1 nuclear protein Ribosomal_S7 PF00177.21 AET41024.1 - 1.1e-35 122.5 0.7 1.8e-35 121.7 0.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e VanZ PF04892.12 AET41025.1 - 4.5e-08 33.8 0.0 8.3e-08 32.9 0.0 1.5 1 1 0 1 1 1 1 VanZ like family EF-hand_4 PF12763.7 AET41026.1 - 5e-32 110.0 0.1 3.8e-09 36.4 0.0 4.4 4 0 0 4 4 4 3 Cytoskeletal-regulatory complex EF hand UBA PF00627.31 AET41026.1 - 6.9e-11 41.8 0.1 2.2e-10 40.2 0.1 1.9 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_7 PF13499.6 AET41026.1 - 7.3e-09 36.0 0.1 0.06 13.8 0.0 4.5 4 1 1 5 5 5 3 EF-hand domain pair EF-hand_6 PF13405.6 AET41026.1 - 9.7e-08 31.4 0.2 0.26 11.3 0.0 4.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 AET41026.1 - 2.1e-07 30.0 0.0 0.11 12.1 0.0 4.0 3 0 0 3 3 3 2 EF hand UBA_4 PF14555.6 AET41026.1 - 0.0003 20.6 0.2 0.0008 19.2 0.2 1.7 1 0 0 1 1 1 1 UBA-like domain ComC PF03047.14 AET41026.1 - 0.013 15.2 0.2 0.78 9.6 0.0 2.9 2 0 0 2 2 2 0 COMC family THOC7 PF05615.13 AET41026.1 - 0.64 10.3 52.2 0.36 11.1 13.2 4.2 1 1 2 3 3 3 0 Tho complex subunit 7 DUF1515 PF07439.11 AET41026.1 - 2.5 8.2 7.4 2.4 8.2 0.1 3.2 2 1 0 3 3 3 0 Protein of unknown function (DUF1515) DUF1359 PF07097.11 AET41026.1 - 3.8 7.8 12.9 0.2 11.9 0.5 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1359) KASH_CCD PF14662.6 AET41026.1 - 4.9 6.9 58.8 0.021 14.7 29.7 2.5 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Spc7 PF08317.11 AET41026.1 - 5.7 5.7 60.6 2.6 6.8 30.3 3.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Nnf1 PF03980.14 AET41027.1 - 1.3e-25 89.9 5.0 1.3e-25 89.9 5.0 1.8 1 1 1 2 2 2 1 Nnf1 bZIP_1 PF00170.21 AET41027.1 - 0.00071 19.6 2.0 0.00071 19.6 2.0 2.4 2 0 0 2 2 2 1 bZIP transcription factor Baculo_PEP_C PF04513.12 AET41027.1 - 0.026 14.6 1.3 0.041 13.9 0.1 2.0 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlaC_arch PF05377.11 AET41027.1 - 0.04 14.3 0.6 0.16 12.4 0.6 2.0 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF4164 PF13747.6 AET41027.1 - 0.1 12.9 0.3 0.1 12.9 0.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) Exonuc_VII_L PF02601.15 AET41027.1 - 4.5 6.8 5.6 22 4.5 5.6 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit CMD PF02627.20 AET41028.1 - 6.1e-05 23.0 0.0 0.00039 20.4 0.0 2.3 3 0 0 3 3 3 1 Carboxymuconolactone decarboxylase family Myotub-related PF06602.14 AET41029.1 - 1.3e-141 471.7 2.4 1.7e-141 471.2 2.4 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 AET41029.1 - 0.0069 16.0 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 AET41029.1 - 0.013 15.3 0.0 0.033 14.0 0.0 1.7 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain GRAM PF02893.20 AET41029.1 - 0.021 14.7 0.0 0.069 13.0 0.0 1.9 1 0 0 1 1 1 0 GRAM domain Y_phosphatase3 PF13350.6 AET41029.1 - 0.1 12.5 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Yippee-Mis18 PF03226.14 AET41030.1 - 7.5e-16 58.2 1.5 8.8e-16 58.0 1.5 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 AET41030.1 - 0.0036 17.5 1.7 0.0054 16.9 1.7 1.2 1 0 0 1 1 1 1 C-terminal domain of RIG-I NAD_binding_6 PF08030.12 AET41031.1 - 3.6e-23 82.4 0.0 6e-23 81.7 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 AET41031.1 - 3.7e-20 72.0 0.3 1.4e-19 70.2 0.1 2.1 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.19 AET41031.1 - 1e-19 70.9 16.6 1e-19 70.9 16.6 2.1 2 0 0 2 2 2 1 Ferric reductase like transmembrane component SNAP PF14938.6 AET41032.1 - 3.8e-106 354.6 11.5 4.3e-106 354.5 11.5 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.17 AET41032.1 - 2.8e-05 23.9 8.2 1.8 8.8 0.0 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 AET41032.1 - 0.00031 21.2 7.9 2.8 8.8 0.2 5.9 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 AET41032.1 - 0.0029 17.9 11.4 1.4 9.3 0.6 4.5 1 1 4 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 AET41032.1 - 0.0031 18.1 1.9 0.13 12.9 0.3 3.3 2 2 1 3 3 3 1 Tetratricopeptide repeat FRB_dom PF08771.11 AET41032.1 - 0.028 14.8 0.7 0.095 13.1 0.1 2.0 2 0 0 2 2 2 0 FKBP12-rapamycin binding domain TPR_14 PF13428.6 AET41032.1 - 0.05 14.4 6.4 0.37 11.7 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 AET41032.1 - 0.052 14.1 1.3 0.052 14.1 1.3 4.0 4 2 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 AET41032.1 - 0.38 10.6 14.2 2 8.4 0.1 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 AET41032.1 - 1.6 8.7 4.7 5.6 7.0 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat OPT PF03169.15 AET41033.1 - 2.9e-183 610.8 55.2 3.4e-183 610.7 55.2 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein CPSase_L_D2 PF02786.17 AET41034.1 - 9.4e-108 358.5 0.0 3.3e-83 278.4 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 AET41034.1 - 5.8e-40 136.4 0.1 1.1e-39 135.6 0.1 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 AET41034.1 - 5.6e-19 68.3 0.0 9.7e-09 35.0 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 AET41034.1 - 3e-15 56.3 0.1 3.2e-07 30.1 0.0 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 AET41034.1 - 1.2e-14 54.2 0.0 2.4e-06 27.3 0.0 2.9 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon RimK PF08443.11 AET41034.1 - 1.3e-05 24.9 0.0 0.025 14.2 0.0 2.5 2 0 0 2 2 2 2 RimK-like ATP-grasp domain ATP-grasp_5 PF13549.6 AET41034.1 - 3.8e-05 23.2 0.4 0.0077 15.7 0.1 2.4 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.22 AET41034.1 - 0.00019 21.5 0.0 0.001 19.2 0.0 2.2 2 0 0 2 2 2 1 MGS-like domain GARS_A PF01071.19 AET41034.1 - 0.0007 19.4 0.1 0.49 10.1 0.0 2.7 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Epimerase PF01370.21 AET41034.1 - 0.14 11.6 0.0 0.72 9.3 0.0 2.0 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family G-alpha PF00503.20 AET41035.1 - 7.4e-103 344.4 0.0 9.9e-103 344.0 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 AET41035.1 - 3.3e-14 52.7 1.0 5.5e-10 39.0 0.2 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AET41035.1 - 2e-05 24.1 1.4 0.0016 17.8 0.1 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 AET41035.1 - 0.00074 19.7 0.4 1.1 9.5 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase SMP_C2CD2L PF18696.1 AET41035.1 - 0.09 12.6 0.1 0.69 9.7 0.0 2.1 2 0 0 2 2 2 0 Synaptotagmin-like, mitochondrial and lipid-binding domain Ras PF00071.22 AET41035.1 - 0.14 11.7 0.4 15 5.2 0.1 2.6 2 1 0 2 2 2 0 Ras family Lipase_3 PF01764.25 AET41036.1 - 1.1e-37 129.1 0.0 2.2e-37 128.1 0.0 1.5 2 0 0 2 2 2 1 Lipase (class 3) Hydrolase_4 PF12146.8 AET41036.1 - 0.038 13.2 0.0 0.066 12.5 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF2974 PF11187.8 AET41036.1 - 0.049 13.2 0.0 9.8 5.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 AET41036.1 - 0.12 12.9 0.0 0.3 11.7 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 AET41036.1 - 0.17 11.6 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Na_Ca_ex PF01699.24 AET41037.1 - 1.1e-46 158.5 42.6 8.9e-26 90.7 12.9 3.0 3 0 0 3 3 3 2 Sodium/calcium exchanger protein FA_desaturase PF00487.24 AET41037.1 - 0.44 10.3 4.2 0.55 10.0 0.1 2.4 2 0 0 2 2 2 0 Fatty acid desaturase PfkB PF00294.24 AET41038.1 - 2.1e-70 237.4 0.1 2.4e-70 237.2 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 AET41038.1 - 0.014 14.8 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase TRAM_LAG1_CLN8 PF03798.16 AET41039.1 - 8.3e-30 104.0 21.1 8.3e-30 104.0 21.1 1.8 2 0 0 2 2 2 1 TLC domain DUF3611 PF12263.8 AET41039.1 - 0.00092 19.2 1.7 0.00092 19.2 1.7 2.2 2 1 1 3 3 3 1 Protein of unknown function (DUF3611) Peptidase_M48_N PF16491.5 AET41040.1 - 7.6e-47 159.5 4.2 7.6e-47 159.5 4.2 1.8 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 AET41040.1 - 3.6e-38 131.3 0.0 6.4e-38 130.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M43 PF05572.13 AET41040.1 - 0.067 13.1 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A SprT-like PF10263.9 AET41040.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 SprT-like family PCI PF01399.27 AET41041.1 - 1.6e-19 70.4 0.2 1.6e-19 70.4 0.2 2.4 2 1 1 3 3 3 1 PCI domain Rpn3_C PF08375.11 AET41041.1 - 1.8e-19 69.9 0.4 6.2e-19 68.2 0.2 2.0 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal TPR_2 PF07719.17 AET41041.1 - 0.34 11.1 1.8 9.2 6.7 0.5 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Med17 PF10156.9 AET41042.1 - 1.6e-162 541.4 12.3 2e-162 541.1 12.3 1.1 1 0 0 1 1 1 1 Subunit 17 of Mediator complex Ribosomal_L27A PF00828.19 AET41042.1 - 0.019 15.6 0.4 0.069 13.8 0.0 2.1 2 0 0 2 2 2 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ilm1 PF10311.9 AET41043.1 - 5.2e-13 49.0 12.6 2e-10 40.6 8.3 2.0 1 1 1 2 2 2 2 Increased loss of mitochondrial DNA protein 1 DUF3487 PF11990.8 AET41043.1 - 0.087 12.7 0.9 0.59 10.0 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3487) EbsA PF17255.2 AET41043.1 - 0.5 10.7 4.9 0.064 13.6 0.9 1.5 2 0 0 2 2 2 0 EbsA-like protein JmjC PF02373.22 AET41044.1 - 2e-39 134.6 0.9 4.4e-39 133.4 0.9 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 AET41044.1 - 1e-09 38.1 5.9 1e-09 38.1 5.9 2.2 2 0 0 2 2 2 1 PHD-finger JmjN PF02375.17 AET41044.1 - 5.7e-09 35.8 0.2 4e-08 33.1 0.0 2.4 2 0 0 2 2 2 1 jmjN domain PHD_2 PF13831.6 AET41044.1 - 0.025 14.1 5.1 0.023 14.3 1.8 2.6 2 0 0 2 2 2 0 PHD-finger C1_1 PF00130.22 AET41044.1 - 0.12 12.2 6.1 0.27 11.1 1.3 2.8 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-HC5HC2H_2 PF13832.6 AET41044.1 - 0.14 12.3 2.2 0.25 11.5 1.0 2.0 1 1 0 1 1 1 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 AET41044.1 - 0.22 11.8 5.5 0.11 12.7 1.9 2.3 2 0 0 2 2 2 0 PHD-like zinc-binding domain zf-RING_2 PF13639.6 AET41044.1 - 0.62 10.4 8.8 3.2 8.1 8.8 2.4 1 0 0 1 1 1 0 Ring finger domain P5CR_dimer PF14748.6 AET41045.1 - 1.4e-32 112.0 0.4 2.4e-32 111.3 0.4 1.4 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 AET41045.1 - 1.7e-11 44.5 0.1 4.6e-11 43.2 0.1 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent PDH PF02153.17 AET41045.1 - 0.0028 16.7 0.3 0.0091 15.0 0.2 1.8 1 1 0 2 2 2 1 Prephenate dehydrogenase ApbA PF02558.16 AET41045.1 - 0.0036 17.0 1.2 0.0075 15.9 0.4 1.9 2 1 0 2 2 2 1 Ketopantoate reductase PanE/ApbA ATP-synt_ab PF00006.25 AET41046.1 - 1.6e-62 210.9 0.0 2.5e-62 210.3 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 AET41046.1 - 4.5e-25 88.0 1.8 1.4e-24 86.4 1.8 1.9 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 AET41046.1 - 0.0021 17.5 0.2 0.0033 16.8 0.2 1.3 1 0 0 1 1 1 1 KaiC NB-ARC PF00931.22 AET41046.1 - 0.0053 16.0 0.8 0.077 12.2 0.1 2.1 2 0 0 2 2 2 1 NB-ARC domain NACHT PF05729.12 AET41046.1 - 0.034 14.0 0.1 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 NACHT domain RsgA_GTPase PF03193.16 AET41046.1 - 0.047 13.6 0.1 0.1 12.5 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA PF00004.29 AET41046.1 - 0.063 13.7 0.1 0.68 10.4 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AET41046.1 - 0.092 13.1 0.6 0.3 11.4 0.2 2.2 2 1 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.6 AET41046.1 - 0.1 12.9 1.2 0.48 10.7 0.2 2.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 AET41046.1 - 0.13 12.6 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase T3SS_ATPase_C PF18269.1 AET41046.1 - 0.14 12.0 0.7 0.85 9.5 0.7 2.1 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain GCV_T PF01571.21 AET41047.1 - 0.069 12.5 0.0 8.7 5.6 0.0 2.3 2 0 0 2 2 2 0 Aminomethyltransferase folate-binding domain Ribosomal_S7 PF00177.21 AET41048.1 - 4.2e-37 127.1 2.2 5.9e-37 126.6 2.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Carn_acyltransf PF00755.20 AET41049.1 - 2.3e-108 363.4 0.0 5.3e-108 362.2 0.0 1.5 1 1 0 1 1 1 1 Choline/Carnitine o-acyltransferase MFS_1 PF07690.16 AET41050.1 - 8.4e-25 87.4 27.6 6.9e-16 58.1 3.9 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 AET41050.1 - 1.6e-07 30.2 23.8 9.1e-05 21.2 6.1 2.5 1 1 1 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 AET41050.1 - 8.5e-07 28.2 9.5 8.5e-07 28.2 9.5 2.6 1 1 2 3 3 3 1 MFS_1 like family OATP PF03137.20 AET41050.1 - 6e-05 21.5 3.8 6e-05 21.5 3.8 3.5 3 2 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family Zn_clus PF00172.18 AET41051.1 - 3e-08 33.7 9.5 5.8e-08 32.7 9.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain eIF2_C PF09173.11 AET41052.1 - 1e-34 118.6 0.3 2.7e-34 117.3 0.3 1.8 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 AET41052.1 - 1.2e-23 83.7 0.1 1.3e-22 80.3 0.1 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 AET41052.1 - 4.6e-10 39.7 0.3 4.6e-10 39.7 0.3 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 AET41052.1 - 0.002 18.1 0.1 0.089 12.7 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 AET41052.1 - 0.003 17.6 0.0 0.0068 16.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 AET41052.1 - 0.033 14.2 0.0 0.11 12.5 0.0 1.8 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain RGS PF00615.19 AET41053.1 - 8.1e-18 64.8 0.3 8.9e-11 42.1 0.1 2.8 2 0 0 2 2 2 2 Regulator of G protein signaling domain DEP PF00610.21 AET41053.1 - 2.2e-13 50.0 0.0 8.5e-12 45.0 0.0 2.6 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Pkinase PF00069.25 AET41054.1 - 8.7e-74 248.2 0.0 1.1e-73 247.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET41054.1 - 7.3e-31 107.4 0.0 6.7e-30 104.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AET41054.1 - 2e-08 33.6 0.0 3.4e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain ORC4_C PF14629.6 AET41055.1 - 6.9e-37 126.9 4.9 1.4e-36 125.9 4.9 1.5 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus Centro_C10orf90 PF17730.1 AET41055.1 - 0.0095 14.8 0.3 0.015 14.2 0.3 1.2 1 0 0 1 1 1 1 Centrosomal C10orf90 AAA_22 PF13401.6 AET41055.1 - 0.0098 16.2 0.7 0.044 14.1 0.1 2.4 1 1 1 2 2 2 1 AAA domain AAA PF00004.29 AET41055.1 - 0.026 14.9 0.0 0.026 14.9 0.0 3.0 4 1 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) Glyco_tran_28_C PF04101.16 AET41055.1 - 0.033 14.2 3.3 1.7 8.6 0.3 2.7 1 1 1 2 2 2 0 Glycosyltransferase family 28 C-terminal domain TrwB_AAD_bind PF10412.9 AET41055.1 - 0.19 10.6 2.9 8.3 5.2 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain RRM_1 PF00076.22 AET41056.1 - 9.3e-09 35.0 0.0 1.7e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Herpes_UL7 PF01677.16 AET41056.1 - 0.037 13.7 0.0 0.059 13.1 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL7 like Ras PF00071.22 AET41058.1 - 1.5e-53 180.7 0.0 1.8e-53 180.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET41058.1 - 6.9e-21 74.7 0.0 1e-20 74.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET41058.1 - 6.2e-08 32.3 0.0 9.5e-08 31.7 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 AET41059.1 - 4.1e-55 185.8 0.0 4.9e-55 185.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET41059.1 - 3e-21 75.9 0.0 4.6e-21 75.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET41059.1 - 8.7e-07 28.6 0.0 1.3e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 AET41059.1 - 8.3e-05 22.2 0.1 0.00022 20.8 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AET41059.1 - 0.072 13.0 0.0 0.29 11.0 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase Gtr1_RagA PF04670.12 AET41059.1 - 0.079 12.3 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Ribosomal_S14 PF00253.21 AET41060.1 - 5.8e-23 80.4 0.5 8.8e-23 79.8 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e QLQ PF08880.11 AET41060.1 - 0.074 12.8 0.4 0.14 11.9 0.2 1.7 1 1 0 1 1 1 0 QLQ SSF PF00474.17 AET41062.1 - 5.1e-10 38.8 29.0 1.2e-09 37.6 29.0 1.6 1 1 0 1 1 1 1 Sodium:solute symporter family Ycf70 PF17382.2 AET41062.1 - 0.1 13.0 0.3 11 6.5 0.0 2.8 2 0 0 2 2 2 0 Uncharacterized Ycf70-like CBFD_NFYB_HMF PF00808.23 AET41063.1 - 4e-12 46.2 0.2 7e-12 45.5 0.2 1.4 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Acetone_carb_G PF08882.11 AET41063.1 - 0.11 12.7 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Acetone carboxylase gamma subunit SecE PF00584.20 AET41064.1 - 1.2e-11 44.4 0.1 1.3e-11 44.3 0.1 1.0 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Nop52 PF05997.12 AET41065.1 - 1.1e-70 237.8 3.8 1.3e-70 237.5 3.8 1.1 1 0 0 1 1 1 1 Nucleolar protein,Nop52 Arm PF00514.23 AET41065.1 - 0.069 13.2 0.1 4.4 7.5 0.0 2.4 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Slu7 PF11708.8 AET41066.1 - 4.6e-15 56.1 8.2 4.6e-15 56.1 8.2 2.5 2 1 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor OCRE PF17780.1 AET41066.1 - 0.056 13.5 0.1 8.9 6.4 0.0 2.5 2 0 0 2 2 2 0 OCRE domain zf-CCHC_4 PF14392.6 AET41066.1 - 0.11 12.3 2.7 0.24 11.2 2.7 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 AET41066.1 - 1.1 9.5 7.7 2.1 8.6 7.7 1.5 1 0 0 1 1 1 0 Zinc knuckle SPX PF03105.19 AET41067.1 - 0.00036 20.6 0.0 0.00036 20.6 0.0 3.9 3 1 1 5 5 5 1 SPX domain Cation_ATPase_C PF00689.21 AET41067.1 - 7.3 6.3 9.7 13 5.5 9.7 1.3 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus SPT2 PF08243.11 AET41068.1 - 1.4e-24 86.8 23.2 1.4e-24 86.8 23.2 2.4 2 0 0 2 2 2 1 SPT2 chromatin protein COX6C PF02937.15 AET41068.1 - 0.048 13.8 0.9 0.14 12.3 0.9 1.7 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIc Rad4 PF03835.15 AET41069.1 - 2.8e-37 127.7 0.9 2.8e-37 127.7 0.9 2.4 4 0 0 4 4 4 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 AET41069.1 - 1.4e-24 86.2 0.1 3.4e-24 85.0 0.1 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 AET41069.1 - 5.6e-17 61.3 0.0 1.2e-16 60.3 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 AET41069.1 - 8e-07 29.9 1.5 1.4e-05 25.9 1.5 3.1 1 1 0 1 1 1 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 AET41069.1 - 0.00048 20.5 0.1 0.0017 18.8 0.0 2.0 2 0 0 2 2 2 1 Transglutaminase-like superfamily CK_II_beta PF01214.18 AET41070.1 - 1.3e-69 233.7 0.0 1.7e-69 233.3 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit HSCB_C PF07743.13 AET41071.1 - 1.7e-21 76.5 2.5 3.3e-21 75.5 2.5 1.5 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 AET41071.1 - 2.3e-06 27.6 0.1 9.7e-06 25.6 0.0 2.0 3 0 0 3 3 3 1 DnaJ domain Wbp11 PF09429.10 AET41071.1 - 0.011 16.1 1.8 0.029 14.8 1.0 2.0 2 0 0 2 2 2 0 WW domain binding protein 11 AbiJ_NTD5 PF18865.1 AET41071.1 - 0.028 14.2 0.7 0.056 13.3 0.1 1.8 2 0 0 2 2 2 0 AbiJ N-terminal domain 5 JAKMIP_CC3 PF16034.5 AET41071.1 - 0.31 11.0 4.1 0.47 10.4 3.6 1.5 1 1 0 1 1 1 0 JAKMIP CC3 domain ATE_C PF04377.15 AET41072.1 - 2.3e-43 148.0 0.9 4.9e-43 147.0 0.9 1.6 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 AET41072.1 - 1.2e-23 83.3 0.3 2.8e-23 82.1 0.3 1.7 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus zf-CRD PF17979.1 AET41073.1 - 0.11 12.5 0.2 0.4 10.8 0.2 1.9 1 0 0 1 1 1 0 Cysteine rich domain with multizinc binding regions Urb2 PF10441.9 AET41073.1 - 0.18 11.7 3.4 0.37 10.7 0.2 2.6 2 0 0 2 2 2 0 Urb2/Npa2 family Aminotran_1_2 PF00155.21 AET41074.1 - 2.4e-17 63.2 0.0 3.2e-17 62.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 AET41074.1 - 0.17 11.1 0.0 0.27 10.5 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family WD40 PF00400.32 AET41075.1 - 3.4e-30 103.6 18.0 4.4e-08 33.6 0.0 7.8 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET41075.1 - 5.6e-16 58.6 0.4 0.058 13.7 0.0 7.1 3 1 3 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 AET41075.1 - 9.9e-11 41.8 0.1 1.8e-09 37.6 0.1 2.5 2 0 0 2 2 2 1 TUP1-like enhancer of split HIRA_B PF09453.10 AET41075.1 - 7.5e-07 28.9 0.0 1.9e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 HIRA B motif WD40_like PF17005.5 AET41075.1 - 0.0015 17.9 0.5 0.75 9.1 0.0 3.5 4 0 0 4 4 4 1 WD40-like domain PD40 PF07676.12 AET41075.1 - 0.024 14.6 0.0 12 6.0 0.0 3.4 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat IKI3 PF04762.12 AET41075.1 - 0.024 12.6 0.2 0.18 9.7 0.0 2.3 2 1 0 2 2 2 0 IKI3 family Toxin_37 PF11415.8 AET41075.1 - 1.9 8.4 5.9 2.4 8.1 0.9 2.6 2 0 0 2 2 2 0 Antifungal peptide termicin Aconitase PF00330.20 AET41076.1 - 2.1e-159 531.4 0.0 2.6e-159 531.1 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 AET41076.1 - 1.8e-43 148.0 0.0 6.6e-43 146.2 0.0 2.0 2 0 0 2 2 2 1 Aconitase C-terminal domain SH3_1 PF00018.28 AET41077.1 - 1e-35 121.1 5.3 1.8e-11 43.4 0.2 4.5 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.6 AET41077.1 - 1.2e-32 111.5 5.5 1.5e-11 43.9 0.4 4.7 4 0 0 4 4 4 3 Variant SH3 domain SHD1 PF03983.12 AET41077.1 - 1.4e-30 104.9 0.1 4.3e-30 103.3 0.1 1.9 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_2 PF07653.17 AET41077.1 - 5.4e-26 90.0 0.8 1.7e-06 27.6 0.0 4.5 4 0 0 4 4 4 4 Variant SH3 domain hSH3 PF14603.6 AET41077.1 - 0.051 14.0 0.6 0.45 11.0 0.0 2.8 4 0 0 4 4 4 0 Helically-extended SH3 domain SAM_4 PF18017.1 AET41077.1 - 0.06 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF962 PF06127.11 AET41078.1 - 7.5e-22 77.2 6.6 2.7e-21 75.4 6.6 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF962) Proteasome PF00227.26 AET41079.1 - 1.2e-46 158.6 0.0 1.8e-46 158.0 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AET41079.1 - 2.1e-15 56.1 0.1 3.7e-15 55.3 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature SAP30_Sin3_bdg PF13867.6 AET41079.1 - 0.012 15.9 0.0 0.026 14.8 0.0 1.5 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 Rsc14 PF08586.10 AET41080.1 - 3.3e-36 124.1 0.1 4.5e-36 123.6 0.1 1.2 1 0 0 1 1 1 1 RSC complex, Rsc14/Ldb7 subunit Gag_p17 PF00540.18 AET41080.1 - 0.036 14.0 0.0 0.068 13.2 0.0 1.5 1 0 0 1 1 1 0 gag gene protein p17 (matrix protein) Fungal_trans PF04082.18 AET41081.1 - 1.5e-14 53.7 2.6 2.8e-14 52.8 2.6 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET41081.1 - 2.5e-06 27.5 15.3 6.8e-06 26.1 15.3 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TetR_C_17 PF17922.1 AET41081.1 - 0.025 14.6 0.0 0.075 13.1 0.0 1.7 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain PUF PF00806.19 AET41082.1 - 3.5e-62 202.7 9.5 1.6e-08 33.8 0.5 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Dpoe2NT PF12213.8 AET41082.1 - 0.065 13.5 0.1 2.1 8.7 0.0 2.7 2 1 0 2 2 2 0 DNA polymerases epsilon N terminal Toxin_17 PF08086.11 AET41082.1 - 0.26 11.6 2.6 0.65 10.3 2.6 1.6 1 0 0 1 1 1 0 Ergtoxin family Zip PF02535.22 AET41082.1 - 2.6 7.2 5.1 3.9 6.6 5.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter AF-4 PF05110.13 AET41082.1 - 4.3 5.3 5.1 5.9 4.8 5.1 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SelP_N PF04592.14 AET41082.1 - 6.2 6.2 16.2 15 4.9 16.2 1.7 1 0 0 1 1 1 0 Selenoprotein P, N terminal region E1-E2_ATPase PF00122.20 AET41083.1 - 4.6e-48 163.1 5.5 1.4e-47 161.6 4.0 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 AET41083.1 - 1.1e-18 68.3 0.1 3.1e-18 66.8 0.1 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 AET41083.1 - 4.8e-12 45.4 0.1 1.8e-11 43.5 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 AET41083.1 - 0.002 17.9 0.1 0.0043 16.8 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AET41083.1 - 0.012 15.7 0.0 0.023 14.8 0.0 1.4 1 0 0 1 1 1 0 Cation transport ATPase (P-type) Zn_clus PF00172.18 AET41084.1 - 5.7e-07 29.6 13.5 1.1e-06 28.6 13.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4176 PF13780.6 AET41084.1 - 0.096 12.7 0.1 0.24 11.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4176) UDPGP PF01704.18 AET41085.1 - 7.9e-185 614.4 0.0 1e-184 614.0 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DUF4301 PF14134.6 AET41085.1 - 0.016 14.0 0.1 0.086 11.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4301) zf-rbx1 PF12678.7 AET41086.1 - 3.8e-09 36.7 5.2 7e-09 35.9 5.2 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 AET41086.1 - 1.6e-08 34.8 7.5 4.6e-08 33.3 7.5 1.8 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 AET41086.1 - 6.3e-07 29.1 2.8 6.3e-07 29.1 2.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AET41086.1 - 7.6e-07 29.0 3.5 1.3e-06 28.3 3.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 AET41086.1 - 3.3e-06 26.9 6.4 6.5e-06 25.9 6.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AET41086.1 - 8.2e-06 25.7 4.0 2e-05 24.5 4.0 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 AET41086.1 - 1.5e-05 24.8 2.8 3e-05 23.8 2.8 1.5 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 AET41086.1 - 4.1e-05 23.2 6.1 0.0024 17.6 0.7 2.6 2 0 0 2 2 2 2 RING-like zinc finger zf-C3HC4_3 PF13920.6 AET41086.1 - 0.00027 20.7 5.3 0.00088 19.1 5.3 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 AET41086.1 - 0.0037 17.3 1.2 0.008 16.2 1.2 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 AET41086.1 - 0.0039 16.8 1.5 0.0039 16.8 1.5 1.9 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 AET41086.1 - 0.048 13.8 5.1 0.19 11.9 5.1 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain zf-P11 PF03854.14 AET41086.1 - 0.43 10.3 2.5 1.5 8.6 2.5 1.9 1 0 0 1 1 1 0 P-11 zinc finger HAD_2 PF13419.6 AET41087.1 - 7.9e-24 84.7 0.0 1e-23 84.3 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AET41087.1 - 6.1e-13 49.5 0.0 1.1e-12 48.6 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 AET41087.1 - 5.5e-06 26.4 0.0 4.3e-05 23.6 0.0 2.3 3 0 0 3 3 3 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 AET41087.1 - 0.00033 21.1 0.0 0.00042 20.8 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Pribosyl_synth PF14572.6 AET41088.1 - 2.3e-40 138.6 3.3 4e-35 121.5 2.5 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 AET41088.1 - 9.4e-40 135.2 1.1 3e-39 133.5 0.0 2.2 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 AET41088.1 - 3.9e-17 62.2 1.6 2.5e-16 59.6 0.7 2.1 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AET41088.1 - 0.006 16.1 0.2 0.01 15.3 0.2 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase ISPD_C PF18706.1 AET41088.1 - 0.065 12.9 0.6 0.15 11.7 0.6 1.6 1 0 0 1 1 1 0 D-ribitol-5-phosphate cytidylyltransferase C-terminal domain BRAP2 PF07576.12 AET41089.1 - 2.3e-31 107.9 0.1 5.6e-31 106.7 0.1 1.6 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 AET41089.1 - 8.3e-22 77.3 8.5 4.3e-21 75.0 8.5 2.3 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 AET41089.1 - 9.8e-09 35.4 9.2 9.8e-09 35.4 9.2 2.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 AET41089.1 - 1.7e-06 27.8 9.5 1.7e-06 27.8 9.5 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 AET41089.1 - 1.1e-05 25.6 6.9 7.2e-05 23.0 6.9 2.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 AET41089.1 - 1.8e-05 24.6 7.8 1.8e-05 24.6 7.8 2.8 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 AET41089.1 - 2.7e-05 23.8 4.2 2.7e-05 23.8 4.2 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 AET41089.1 - 3.7e-05 23.5 16.2 0.0015 18.4 5.9 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AET41089.1 - 5.4e-05 23.1 4.3 5.4e-05 23.1 4.3 3.0 1 1 1 2 2 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 AET41089.1 - 0.0005 20.1 4.4 0.0019 18.2 4.4 2.0 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 AET41089.1 - 0.00071 19.4 7.8 0.00071 19.4 7.8 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 AET41089.1 - 0.011 15.5 7.6 0.011 15.5 7.6 2.0 2 0 0 2 2 1 0 RING/Ubox like zinc-binding domain HALZ PF02183.18 AET41089.1 - 0.023 14.9 4.2 0.33 11.2 0.6 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper PhoQ_Sensor PF08918.10 AET41089.1 - 0.058 13.2 1.0 0.1 12.4 1.0 1.3 1 0 0 1 1 1 0 PhoQ Sensor Prok-RING_4 PF14447.6 AET41089.1 - 0.081 12.8 20.6 0.31 10.9 9.5 3.5 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 Rootletin PF15035.6 AET41089.1 - 0.15 12.0 9.1 0.28 11.2 9.1 1.4 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF4407 PF14362.6 AET41089.1 - 0.24 10.7 2.5 0.38 10.1 2.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 AET41089.1 - 0.25 11.4 5.5 0.2 11.7 3.1 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 AET41089.1 - 0.25 11.3 9.3 0.67 10.0 2.7 2.2 1 1 1 2 2 2 0 Laminin Domain II TMF_TATA_bd PF12325.8 AET41089.1 - 0.85 9.9 13.1 0.65 10.2 3.5 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Atg14 PF10186.9 AET41089.1 - 1.2 8.2 9.2 2.1 7.4 9.2 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DivIC PF04977.15 AET41089.1 - 1.2 8.9 5.4 2.5 7.9 1.1 2.5 2 0 0 2 2 2 0 Septum formation initiator Uso1_p115_C PF04871.13 AET41089.1 - 3.3 8.1 12.6 3.4 8.1 0.4 2.6 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4404 PF14357.6 AET41089.1 - 4.9 7.9 8.3 0.48 11.1 3.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Form_Nir_trans PF01226.17 AET41090.1 - 2.2e-59 200.7 26.6 3.1e-59 200.2 26.6 1.2 1 0 0 1 1 1 1 Formate/nitrite transporter Val_tRNA-synt_C PF10458.9 AET41090.1 - 0.067 13.5 0.0 0.18 12.1 0.0 1.7 1 0 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm HEAT PF02985.22 AET41091.1 - 0.0019 18.3 0.0 15 6.2 0.0 4.8 4 0 0 4 4 4 1 HEAT repeat CTD_bind PF04818.13 AET41091.1 - 0.029 15.2 0.1 0.81 10.6 0.0 3.7 2 0 0 2 2 2 0 RNA polymerase II-binding domain. FANCI_S2 PF14676.6 AET41091.1 - 0.038 14.3 0.6 1.6 9.0 0.0 3.5 4 0 0 4 4 4 0 FANCI solenoid 2 Cnd1 PF12717.7 AET41091.1 - 0.16 12.0 3.5 2.4 8.2 0.4 4.1 4 0 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 PHD PF00628.29 AET41092.1 - 1.1e-15 57.2 19.5 4.2e-10 39.4 7.6 3.1 2 1 1 3 3 3 2 PHD-finger PHD_2 PF13831.6 AET41092.1 - 0.0074 15.8 10.3 0.61 9.7 0.2 3.7 3 0 0 3 3 3 2 PHD-finger zf-HC5HC2H PF13771.6 AET41092.1 - 0.01 16.0 5.6 0.082 13.2 1.6 2.8 2 0 0 2 2 2 0 PHD-like zinc-binding domain C1_1 PF00130.22 AET41092.1 - 1.5 8.8 11.0 5.9 6.9 0.8 2.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_4 PF16866.5 AET41092.1 - 4.4 7.5 18.1 0.039 14.0 3.4 3.0 2 1 0 2 2 2 0 PHD-finger zf-RING-like PF08746.11 AET41092.1 - 4.9 7.6 9.3 2.4 8.5 0.5 2.6 2 0 0 2 2 2 0 RING-like domain dsDNA_bind PF01984.20 AET41093.1 - 2.3e-23 82.6 8.3 6.2e-22 78.0 8.3 2.0 1 1 0 1 1 1 1 Double-stranded DNA-binding domain Transket_pyr PF02779.24 AET41093.1 - 0.0095 15.6 0.0 0.011 15.4 0.0 1.1 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Cu_amine_oxid PF01179.20 AET41094.1 - 4.1e-144 480.5 0.1 5e-144 480.2 0.1 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 AET41094.1 - 0.055 13.7 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 Copper amine oxidase, N2 domain Cyt-b5 PF00173.28 AET41095.1 - 3.4e-13 49.5 0.0 6.3e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain HMG_box PF00505.19 AET41096.1 - 3.5e-33 113.8 12.7 1.4e-17 63.9 4.6 2.7 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 AET41096.1 - 2.4e-17 63.3 8.2 1.2e-10 41.8 3.1 3.5 4 0 0 4 4 4 2 HMG-box domain CHDNT PF08073.12 AET41096.1 - 1.1e-07 31.6 0.0 0.012 15.5 0.0 2.7 2 0 0 2 2 2 2 CHDNT (NUC034) domain zinc_ribbon_6 PF14599.6 AET41097.1 - 1.1e-22 79.8 3.5 1.1e-22 79.8 3.5 3.5 3 0 0 3 3 3 1 Zinc-ribbon zf-CHY PF05495.12 AET41097.1 - 1.8e-15 57.2 17.8 1.8e-15 57.2 17.8 3.7 2 1 1 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.6 AET41097.1 - 5.2e-08 33.1 8.6 5.2e-08 33.1 8.6 5.1 4 1 1 5 5 5 1 Ring finger domain zf-RING_UBOX PF13445.6 AET41097.1 - 0.00021 21.3 7.5 0.00021 21.3 7.5 4.5 5 0 0 5 5 5 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 AET41097.1 - 0.00031 20.5 9.9 0.00031 20.5 9.9 4.6 3 2 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AET41097.1 - 0.0005 20.0 11.3 0.0005 20.0 11.3 6.3 4 3 1 5 5 5 1 zinc-RING finger domain Prok-RING_4 PF14447.6 AET41097.1 - 0.0012 18.6 4.8 0.0012 18.6 4.8 5.5 4 2 1 5 5 5 2 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 AET41097.1 - 6.5 6.6 12.4 0.14 11.9 4.0 2.7 3 0 0 3 3 3 0 RING-like zinc finger Cg6151-P PF10233.9 AET41098.1 - 6.8e-36 123.0 12.9 8.4e-36 122.7 12.9 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P Jiraiya PF15038.6 AET41098.1 - 0.28 10.6 6.1 0.12 11.8 3.8 1.5 1 1 0 1 1 1 0 Jiraiya PhrC_PhrF PF11131.8 AET41098.1 - 1.8 8.2 4.3 0.56 9.8 0.6 2.0 2 0 0 2 2 2 0 Rap-phr extracellular signalling PRA1 PF03208.19 AET41098.1 - 2.2 7.9 11.0 3.3 7.3 11.0 1.3 1 1 0 1 1 1 0 PRA1 family protein DUF5325 PF17259.2 AET41098.1 - 2.7 7.9 10.2 1.9 8.4 0.3 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5325) zf-C2H2 PF00096.26 AET41099.1 - 0.00045 20.5 6.1 0.00045 20.5 6.1 3.6 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AET41099.1 - 0.045 14.6 6.4 0.045 14.6 6.4 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger PyrI_C PF02748.15 AET41099.1 - 0.18 11.7 0.5 1 9.3 0.1 2.1 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-H2C2_2 PF13465.6 AET41099.1 - 0.32 11.5 19.1 0.39 11.2 1.5 3.6 3 0 0 3 3 3 0 Zinc-finger double domain zf-H2C2_5 PF13909.6 AET41099.1 - 5.7 6.8 21.4 1.5 8.7 6.8 2.9 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Acetyltransf_1 PF00583.25 AET41100.1 - 1.7e-08 34.7 0.0 4.9e-08 33.2 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AET41100.1 - 7.6e-07 29.5 0.0 4.2e-06 27.1 0.0 2.3 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AET41100.1 - 0.00012 22.0 0.0 0.00045 20.2 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AET41100.1 - 0.0021 18.0 0.0 0.0062 16.5 0.0 1.8 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 AET41100.1 - 0.086 13.5 0.0 0.22 12.2 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain NIF PF03031.18 AET41101.1 - 1.1e-49 168.1 0.1 1.5e-49 167.8 0.1 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase MFS_1 PF07690.16 AET41102.1 - 9.8e-37 126.7 18.0 1.2e-36 126.4 17.4 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AET41102.1 - 2.8e-13 49.5 8.5 2.8e-13 49.5 8.5 2.8 2 1 0 2 2 2 1 Sugar (and other) transporter Malic_M PF03949.15 AET41103.1 - 1.5e-82 276.7 0.0 2e-82 276.3 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 AET41103.1 - 2.9e-61 206.5 0.0 4.5e-61 205.8 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain eRF1_2 PF03464.15 AET41103.1 - 0.19 12.0 0.1 0.41 10.9 0.1 1.5 1 0 0 1 1 1 0 eRF1 domain 2 TFIIE_alpha PF02002.17 AET41104.1 - 2.4e-30 104.5 0.9 5.3e-30 103.4 0.1 2.0 2 0 0 2 2 2 1 TFIIE alpha subunit TF_Zn_Ribbon PF08271.12 AET41104.1 - 3.8e-09 35.9 0.2 9.1e-09 34.7 0.2 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding GntR PF00392.21 AET41104.1 - 0.05 13.3 0.0 0.26 11.0 0.0 2.2 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family zf-CHY PF05495.12 AET41104.1 - 0.08 13.4 0.3 0.16 12.5 0.3 1.4 1 0 0 1 1 1 0 CHY zinc finger HTH_37 PF13744.6 AET41104.1 - 0.085 12.8 1.9 2.2 8.3 0.0 3.2 3 0 0 3 3 3 0 Helix-turn-helix domain DUF4192 PF13830.6 AET41104.1 - 2.2 8.3 9.6 0.36 10.8 1.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4192) ThiF PF00899.21 AET41105.1 - 2.2e-42 145.1 0.0 3.3e-42 144.5 0.0 1.1 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 AET41105.1 - 0.00065 19.8 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 AET41105.1 - 0.00084 19.6 0.0 0.0022 18.2 0.0 1.7 1 0 0 1 1 1 1 TrkA-N domain Sacchrp_dh_NADP PF03435.18 AET41105.1 - 0.0047 17.2 1.4 0.036 14.3 1.4 2.3 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain UDPG_MGDP_dh_N PF03721.14 AET41105.1 - 0.014 15.0 0.4 0.014 15.0 0.4 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 AET41105.1 - 0.039 13.6 0.0 0.072 12.7 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.6 AET41105.1 - 0.12 12.9 0.1 0.39 11.2 0.0 2.0 2 0 0 2 2 2 0 Putative NAD(P)-binding Mito_carr PF00153.27 AET41106.1 - 2.3e-58 194.1 1.9 2.3e-19 69.1 0.1 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.27 AET41107.1 - 2.1e-58 194.2 3.1 3.4e-21 75.0 1.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2370 PF10176.9 AET41108.1 - 1.1e-80 270.5 0.7 3.7e-80 268.8 0.0 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF2370) DUF202 PF02656.15 AET41108.1 - 0.15 12.5 0.1 3.7 8.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF202) SNF5 PF04855.12 AET41109.1 - 1.3e-50 172.5 1.8 2.8e-33 115.7 0.0 4.3 3 1 1 4 4 4 2 SNF5 / SMARCB1 / INI1 Tim54 PF11711.8 AET41109.1 - 0.081 11.7 15.3 0.14 11.0 15.3 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Mem_trans PF03547.18 AET41109.1 - 0.13 10.6 1.1 0.15 10.4 1.1 1.2 1 0 0 1 1 1 0 Membrane transport protein Presenilin PF01080.17 AET41109.1 - 0.45 9.2 25.7 0.74 8.5 25.7 1.4 1 0 0 1 1 1 0 Presenilin SpoIIP PF07454.11 AET41109.1 - 0.61 9.5 17.9 1.3 8.4 17.9 1.6 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CDC45 PF02724.14 AET41109.1 - 0.65 8.2 16.6 1.1 7.5 16.6 1.2 1 0 0 1 1 1 0 CDC45-like protein eIF-3_zeta PF05091.12 AET41109.1 - 2.2 7.2 26.6 3.7 6.4 26.6 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SLC12 PF03522.15 AET41109.1 - 4.3 6.3 24.2 7.2 5.5 24.2 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Adap_comp_sub PF00928.21 AET41110.1 - 7.8e-32 110.7 0.0 1.1e-31 110.2 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 AET41110.1 - 0.0057 16.6 0.0 0.01 15.8 0.0 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain FSA_C PF10479.9 AET41110.1 - 0.11 10.6 5.0 1.8 6.6 0.0 2.3 2 0 0 2 2 2 0 Fragile site-associated protein C-terminus adh_short PF00106.25 AET41111.1 - 4.2e-87 290.6 13.5 2.9e-46 157.4 2.2 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 AET41111.1 - 6e-69 232.2 7.7 6.2e-37 127.4 0.7 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AET41111.1 - 2.1e-33 115.8 6.6 2.5e-16 60.1 1.0 2.3 2 0 0 2 2 2 2 KR domain MaoC_dehydratas PF01575.19 AET41111.1 - 4.5e-25 87.6 0.0 1.1e-24 86.4 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain DUF1776 PF08643.10 AET41111.1 - 0.081 12.3 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) PglL_A PF15864.5 AET41111.1 - 0.6 9.9 6.5 5.4 6.8 1.0 2.6 2 0 0 2 2 2 0 Protein glycosylation ligase 3HCDH_N PF02737.18 AET41111.1 - 3.9 7.3 6.8 3.9 7.3 0.2 3.0 4 0 0 4 4 4 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain QCR10 PF09796.9 AET41112.1 - 5.4e-28 96.9 0.8 7.6e-28 96.4 0.8 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) BLOC1_2 PF10046.9 AET41113.1 - 0.02 15.1 0.9 0.02 15.1 0.9 4.0 4 1 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TolA_bind_tri PF16331.5 AET41113.1 - 1.6 8.9 20.2 2.9 8.0 8.2 4.2 3 1 1 4 4 4 0 TolA binding protein trimerisation DHR10 PF18595.1 AET41113.1 - 5.2 7.2 41.2 0.05 13.6 13.1 4.1 3 2 0 3 3 3 0 Designed helical repeat protein 10 domain SDA1 PF05285.12 AET41114.1 - 0.0071 15.8 14.4 0.011 15.2 14.4 1.2 1 0 0 1 1 1 1 SDA1 NOA36 PF06524.12 AET41114.1 - 0.015 14.6 26.8 0.029 13.7 26.8 1.4 1 0 0 1 1 1 0 NOA36 protein DUF913 PF06025.12 AET41114.1 - 0.032 13.2 0.7 0.053 12.5 0.7 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PPP4R2 PF09184.11 AET41114.1 - 0.034 13.7 13.4 0.065 12.8 13.4 1.6 1 0 0 1 1 1 0 PPP4R2 CDC45 PF02724.14 AET41114.1 - 0.042 12.2 9.9 0.057 11.7 9.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 AET41114.1 - 0.069 11.4 19.1 0.093 10.9 19.1 1.1 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 AET41114.1 - 0.3 9.8 3.2 0.38 9.5 3.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BUD22 PF09073.10 AET41114.1 - 0.79 9.0 18.4 1.3 8.2 18.4 1.3 1 0 0 1 1 1 0 BUD22 RXT2_N PF08595.11 AET41114.1 - 1.2 9.2 13.4 2.4 8.1 13.4 1.6 1 0 0 1 1 1 0 RXT2-like, N-terminal ETF PF01012.21 AET41115.1 - 1.1e-32 113.4 0.5 1.7e-32 112.8 0.5 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 AET41115.1 - 1.1e-32 111.9 0.3 2e-32 111.0 0.3 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain Transcrip_reg PF01709.20 AET41116.1 - 3.4e-78 262.4 1.4 4.1e-78 262.1 1.4 1.1 1 0 0 1 1 1 1 Transcriptional regulator DUF3656 PF12392.8 AET41116.1 - 0.0045 17.6 0.1 0.019 15.6 0.0 2.0 2 0 0 2 2 2 1 Collagenase DUF5059 PF16502.5 AET41116.1 - 0.092 11.5 0.0 0.18 10.5 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5059) ATP-synt_F PF01990.17 AET41117.1 - 1.8e-32 111.5 0.2 2.1e-32 111.3 0.2 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DUF1882 PF08966.11 AET41117.1 - 0.015 15.5 0.2 0.027 14.7 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1882) fn3_2 PF16893.5 AET41118.1 - 1.6e-38 130.7 0.2 3.7e-38 129.5 0.2 1.6 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 AET41118.1 - 1.9e-24 85.3 0.2 3.4e-24 84.5 0.2 1.4 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus BRCT PF00533.26 AET41118.1 - 1.2e-09 38.4 0.0 3.7e-09 36.8 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 AET41118.1 - 1.6e-05 24.7 0.0 3.4e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain fn3 PF00041.21 AET41118.1 - 0.00015 22.0 0.0 0.00062 20.1 0.0 2.0 2 0 0 2 2 2 1 Fibronectin type III domain DUF3006 PF11213.8 AET41118.1 - 0.00082 19.6 0.1 0.00082 19.6 0.1 3.6 4 0 0 4 4 4 1 Protein of unknown function (DUF3006) LIG3_BRCT PF16759.5 AET41118.1 - 0.033 14.5 0.0 0.11 12.8 0.0 1.9 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain BRCT_2 PF16589.5 AET41118.1 - 0.048 14.1 0.2 0.18 12.2 0.0 2.0 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain B12D PF06522.11 AET41119.1 - 0.041 13.7 0.0 0.053 13.3 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit Mito_carr PF00153.27 AET41120.1 - 2e-69 229.6 3.0 7e-25 86.8 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 AET41120.1 - 0.026 13.7 0.1 9.2 5.3 0.0 3.1 3 0 0 3 3 3 0 Gammaproteobacterial serine protease Gtr1_RagA PF04670.12 AET41121.1 - 1.8e-67 227.1 0.2 2.6e-67 226.6 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 AET41121.1 - 0.0025 17.3 0.1 0.0082 15.6 0.0 2.0 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_14 PF13173.6 AET41121.1 - 0.046 13.7 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain GTP_cyclohydro2 PF00925.20 AET41121.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 GTP cyclohydrolase II TYW3 PF02676.14 AET41122.1 - 5.1e-63 212.3 0.0 5.7e-63 212.1 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase TYW3 Glyco_tran_28_C PF04101.16 AET41123.1 - 3.7e-22 79.1 0.0 6.9e-22 78.2 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain E1-E2_ATPase PF00122.20 AET41124.1 - 2.9e-44 150.7 0.0 2.9e-44 150.7 0.0 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 AET41124.1 - 8.7e-32 111.1 0.0 1.4e-31 110.4 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 AET41124.1 - 8.1e-10 39.0 6.5 9.1e-07 29.2 0.5 4.8 4 0 0 4 4 4 1 Heavy-metal-associated domain HAD PF12710.7 AET41124.1 - 2.3e-06 28.1 0.0 5.9e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AET41124.1 - 6.6e-05 22.8 0.2 0.09 12.5 0.1 2.7 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase SCVP PF17619.2 AET41124.1 - 0.079 13.8 1.2 56 4.7 0.1 3.5 3 0 0 3 3 3 0 Secreted clade V proteins ELFV_dehydrog PF00208.21 AET41125.1 - 2.1e-62 211.0 0.0 4.2e-62 210.0 0.0 1.5 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 AET41125.1 - 8.6e-19 66.7 0.0 1.6e-12 45.9 0.0 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 AET41125.1 - 0.0095 15.8 0.0 0.031 14.2 0.0 1.8 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain GAS PF13851.6 AET41125.1 - 0.5 9.7 4.9 0.39 10.0 1.3 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding NPR3 PF03666.13 AET41126.1 - 2.8e-163 544.0 0.0 2.8e-163 544.0 0.0 2.2 3 0 0 3 3 3 1 Nitrogen Permease regulator of amino acid transport activity 3 NPR2 PF06218.11 AET41126.1 - 0.091 11.5 2.5 2.2 6.9 0.0 2.8 2 1 0 2 2 2 0 Nitrogen permease regulator 2 RRM_1 PF00076.22 AET41127.1 - 6.3e-31 106.0 4.2 1.6e-14 53.5 0.4 4.1 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Myc_N PF01056.18 AET41127.1 - 0.00022 21.3 2.2 0.00022 21.3 2.2 2.3 2 0 0 2 2 2 1 Myc amino-terminal region RRM_3 PF08777.11 AET41127.1 - 0.00023 21.1 0.3 0.71 9.9 0.0 2.6 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM PF05172.13 AET41127.1 - 0.0015 18.4 0.0 0.16 12.0 0.0 3.1 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 AET41127.1 - 0.011 15.3 0.0 0.18 11.4 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 AET41127.1 - 0.043 13.8 0.6 17 5.5 0.0 3.2 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 AET41127.1 - 0.12 12.3 0.0 10 6.1 0.0 2.6 2 0 0 2 2 2 0 Occluded RNA-recognition motif TFIIE-A_C PF11521.8 AET41127.1 - 4.7 7.6 16.5 2 8.8 4.0 2.5 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha FAM176 PF14851.6 AET41127.1 - 5.7 6.6 10.7 8.6 6.0 2.5 2.5 2 0 0 2 2 2 0 FAM176 family CENP-B_dimeris PF09026.10 AET41127.1 - 9.3 6.7 20.9 5 7.6 4.7 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain AAA_2 PF07724.14 AET41128.1 - 1.2e-45 155.7 0.0 8.7e-45 152.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 AET41128.1 - 1.2e-28 99.1 0.5 1.2e-28 99.1 0.5 3.0 1 1 1 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 AET41128.1 - 1.8e-23 82.4 0.2 8.3e-23 80.3 0.2 2.3 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 AET41128.1 - 1.9e-21 76.9 0.0 2.2e-12 47.6 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AET41128.1 - 5e-16 58.9 0.0 2.2e-09 37.4 0.0 3.2 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 AET41128.1 - 2.5e-12 46.8 0.0 3.9e-08 33.2 0.0 2.6 2 1 0 2 2 2 2 Sigma-54 interaction domain Clp_N PF02861.20 AET41128.1 - 2.6e-12 46.7 1.9 2.4e-06 27.5 0.0 3.4 2 1 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component AAA_16 PF13191.6 AET41128.1 - 2.6e-10 41.0 4.9 0.00023 21.6 0.0 4.3 4 1 1 5 5 4 2 AAA ATPase domain AAA_22 PF13401.6 AET41128.1 - 4.8e-08 33.4 0.3 0.012 15.9 0.0 4.2 2 2 0 2 2 2 2 AAA domain AAA_14 PF13173.6 AET41128.1 - 2.1e-06 27.8 0.0 0.069 13.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain TniB PF05621.11 AET41128.1 - 3.5e-05 23.3 0.0 0.039 13.4 0.0 4.1 2 1 1 3 3 3 1 Bacterial TniB protein TIP49 PF06068.13 AET41128.1 - 4.9e-05 22.7 0.2 0.46 9.6 0.0 3.2 3 0 0 3 3 3 2 TIP49 P-loop domain AAA_7 PF12775.7 AET41128.1 - 0.00011 21.7 0.0 0.17 11.4 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region Mg_chelatase PF01078.21 AET41128.1 - 0.00027 20.4 0.1 0.7 9.2 0.0 3.3 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 AET41128.1 - 0.00034 20.5 0.0 0.13 12.1 0.0 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 AET41128.1 - 0.0006 19.6 0.0 0.23 11.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 AET41128.1 - 0.0012 18.7 0.0 0.48 10.3 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA_33 PF13671.6 AET41128.1 - 0.0013 18.9 0.0 0.11 12.6 0.0 3.1 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 AET41128.1 - 0.0054 16.0 0.3 0.28 10.4 0.0 3.0 3 0 0 3 3 3 1 Zeta toxin AAA_30 PF13604.6 AET41128.1 - 0.0055 16.4 0.0 0.5 10.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain Torsin PF06309.11 AET41128.1 - 0.0063 16.6 0.0 0.033 14.3 0.0 2.3 2 0 0 2 2 1 1 Torsin ATPase_2 PF01637.18 AET41128.1 - 0.011 15.7 0.9 13 5.6 0.1 3.8 3 1 1 4 4 3 0 ATPase domain predominantly from Archaea TsaE PF02367.17 AET41128.1 - 0.013 15.4 0.0 1.1 9.3 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 AET41128.1 - 0.017 15.7 0.1 0.51 10.9 0.0 3.0 2 0 0 2 2 2 0 AAA domain GAS PF13851.6 AET41128.1 - 0.018 14.4 11.4 0.04 13.3 11.4 1.5 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding AAA_19 PF13245.6 AET41128.1 - 0.02 15.2 0.2 0.97 9.8 0.0 3.0 2 2 1 3 3 3 0 AAA domain IstB_IS21 PF01695.17 AET41128.1 - 0.022 14.5 0.0 1.8 8.3 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein Viral_helicase1 PF01443.18 AET41128.1 - 0.029 14.1 0.0 1.4 8.6 0.0 2.6 2 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Roc PF08477.13 AET41128.1 - 0.032 14.4 0.0 13 6.1 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase APS_kinase PF01583.20 AET41128.1 - 0.053 13.4 0.0 0.17 11.8 0.0 1.8 2 0 0 2 2 1 0 Adenylylsulphate kinase SRPRB PF09439.10 AET41128.1 - 0.056 12.9 0.2 2.7 7.4 0.0 2.8 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit ResIII PF04851.15 AET41128.1 - 0.059 13.4 0.0 14 5.7 0.0 3.7 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit SRP54 PF00448.22 AET41128.1 - 0.11 12.1 0.0 1.5 8.4 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 AET41128.1 - 0.12 12.7 0.2 21 5.6 0.0 3.0 3 0 0 3 3 3 0 RNA helicase PEPCK_ATP PF01293.20 AET41128.1 - 0.19 10.3 0.0 0.37 9.4 0.0 1.4 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase AAA_23 PF13476.6 AET41128.1 - 0.37 11.3 11.4 0.54 10.7 3.0 3.9 4 0 0 4 4 3 0 AAA domain Spc7 PF08317.11 AET41128.1 - 1.6 7.6 15.1 2.7 6.8 15.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein UPF0242 PF06785.11 AET41128.1 - 2.4 8.2 10.3 5.7 7.0 10.3 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Fe-S_biosyn PF01521.20 AET41130.1 - 3.4e-18 65.9 0.0 7.2e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF3853 PF12964.7 AET41130.1 - 0.065 13.4 0.3 0.2 11.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3853) Creatinase_N_2 PF16189.5 AET41131.1 - 6.1e-45 153.2 0.2 3.2e-44 150.9 0.1 2.2 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 AET41131.1 - 3.2e-41 141.3 0.0 5.4e-41 140.6 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 AET41131.1 - 1.9e-20 72.7 0.1 5.1e-20 71.3 0.1 1.8 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 AET41131.1 - 5e-11 43.4 0.0 2e-10 41.4 0.0 2.0 2 1 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Cofilin_ADF PF00241.20 AET41132.1 - 3.8e-15 55.7 0.0 4.6e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Ribosomal_S13_N PF08069.12 AET41133.1 - 2e-24 85.4 0.2 3.6e-24 84.6 0.2 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 AET41133.1 - 1.5e-14 53.9 0.5 2.7e-14 53.1 0.2 1.5 2 0 0 2 2 2 1 Ribosomal protein S15 USP19_linker PF16602.5 AET41135.1 - 0.05 14.1 0.6 0.05 14.1 0.6 2.4 3 1 0 3 3 3 0 Linker region of USP19 deubiquitinase Chorion_2 PF03964.15 AET41135.1 - 0.34 11.8 10.9 0.054 14.3 1.1 2.4 2 0 0 2 2 2 0 Chorion family 2 Macoilin PF09726.9 AET41135.1 - 2.1 6.8 13.7 0.12 10.9 1.1 2.1 2 0 0 2 2 2 0 Macoilin family DUF3446 PF11928.8 AET41135.1 - 5 7.5 16.9 0.49 10.7 11.6 2.1 2 0 0 2 2 2 0 Early growth response N-terminal domain Ndc1_Nup PF09531.10 AET41135.1 - 8.2 5.0 14.7 3.7 6.1 1.2 2.2 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup MFS_1 PF07690.16 AET41137.1 - 1.3e-31 109.8 21.1 1.9e-31 109.3 21.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Jagunal PF07086.12 AET41137.1 - 0.0046 17.1 0.7 0.0046 17.1 0.7 1.9 2 0 0 2 2 2 1 Jagunal, ER re-organisation during oogenesis WW PF00397.26 AET41138.1 - 3.1e-08 33.6 0.7 5.8e-08 32.7 0.7 1.5 1 0 0 1 1 1 1 WW domain G_path_suppress PF15991.5 AET41138.1 - 0.16 12.1 8.1 0.2 11.8 8.1 1.1 1 0 0 1 1 1 0 G-protein pathway suppressor DUF2076 PF09849.9 AET41138.1 - 2.9 7.9 28.9 17 5.4 28.6 2.0 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) WD40 PF00400.32 AET41139.1 - 2e-34 117.1 14.2 1.1e-05 26.0 0.4 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat CDC4_D PF16856.5 AET41139.1 - 1.7e-18 66.2 2.5 1.7e-18 66.2 2.5 1.9 2 0 0 2 2 2 1 Cell division control protein 4 dimerisation domain F-box-like PF12937.7 AET41139.1 - 2.7e-08 33.6 0.1 6.3e-08 32.4 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 AET41139.1 - 2.1e-07 30.6 1.4 4.6e-07 29.6 0.4 2.1 1 1 1 2 2 2 1 F-box domain ANAPC4_WD40 PF12894.7 AET41139.1 - 0.00031 21.0 1.1 0.24 11.7 0.1 4.7 3 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AET41139.1 - 0.0019 17.6 1.4 2 7.7 0.6 3.2 2 1 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 AET41139.1 - 0.027 13.1 5.8 0.89 8.1 0.1 4.2 2 2 1 4 4 4 0 Nucleoporin Nup120/160 PRANC PF09372.10 AET41139.1 - 0.031 14.6 0.1 0.1 13.0 0.1 1.9 1 0 0 1 1 1 0 PRANC domain DED PF01335.21 AET41139.1 - 0.049 13.9 3.7 0.23 11.8 0.9 2.4 2 0 0 2 2 2 0 Death effector domain SMC_N PF02463.19 AET41141.1 - 5.1e-52 176.5 41.8 2.3e-51 174.4 41.8 2.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 AET41141.1 - 3.1e-25 88.7 0.0 1.6e-24 86.4 0.0 2.3 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 AET41141.1 - 3.1e-10 40.3 15.7 4.7e-06 26.6 0.1 3.8 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 AET41141.1 - 1.5e-08 34.8 14.8 1.5e-08 34.8 14.8 4.3 2 2 2 4 4 2 1 AAA ATPase domain AAA_29 PF13555.6 AET41141.1 - 5.9e-08 32.3 0.1 1.2e-07 31.3 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.6 AET41141.1 - 0.00071 18.4 10.7 0.00071 18.4 10.7 5.5 3 2 3 6 6 6 2 AAA domain CENP-F_leu_zip PF10473.9 AET41141.1 - 0.0054 16.8 28.5 0.0054 16.8 28.5 8.6 3 3 5 8 8 5 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FliJ PF02050.16 AET41141.1 - 0.0056 16.9 4.1 0.0056 16.9 4.1 7.2 4 3 4 8 8 8 1 Flagellar FliJ protein Mce4_CUP1 PF11887.8 AET41141.1 - 0.016 14.7 2.6 0.41 10.0 0.1 2.9 3 0 0 3 3 3 0 Cholesterol uptake porter CUP1 of Mce4, putative DUF4407 PF14362.6 AET41141.1 - 0.032 13.6 50.8 0.036 13.4 1.3 5.0 3 2 1 4 4 4 0 Domain of unknown function (DUF4407) DUF2393 PF09624.10 AET41141.1 - 0.059 13.4 3.0 0.35 10.8 3.0 2.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2393) ABC_tran PF00005.27 AET41141.1 - 0.068 13.7 0.0 0.068 13.7 0.0 6.1 4 3 0 4 4 2 0 ABC transporter SbcCD_C PF13558.6 AET41141.1 - 0.087 13.1 0.0 0.32 11.3 0.0 2.0 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF1192 PF06698.11 AET41141.1 - 1.1 9.4 8.5 4.7 7.3 1.0 4.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) Ras PF00071.22 AET41142.1 - 1.1e-63 213.7 0.5 1.2e-63 213.5 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AET41142.1 - 4.8e-37 126.8 0.3 6.7e-37 126.4 0.3 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET41142.1 - 2.9e-18 65.9 0.1 3.6e-18 65.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AET41142.1 - 3.6e-07 29.8 0.1 4.1e-07 29.6 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 AET41142.1 - 8.3e-07 28.6 0.1 1e-06 28.3 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 AET41142.1 - 1.8e-06 28.0 0.1 3.2e-06 27.2 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AET41142.1 - 1.9e-06 27.9 0.2 0.052 13.4 0.0 2.2 2 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 AET41142.1 - 8e-06 25.5 0.3 5.6e-05 22.8 0.2 2.0 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 AET41142.1 - 0.0013 18.3 0.0 0.012 15.2 0.0 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B MCM PF00493.23 AET41142.1 - 0.0033 16.5 0.0 0.024 13.7 0.0 2.0 2 0 0 2 2 2 1 MCM P-loop domain AAA_7 PF12775.7 AET41142.1 - 0.006 16.1 0.0 0.019 14.5 0.0 1.7 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 AET41142.1 - 0.018 15.3 0.1 0.38 11.0 0.1 2.6 1 1 1 2 2 2 0 AAA domain AAA PF00004.29 AET41142.1 - 0.038 14.4 0.0 0.88 10.0 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.20 AET41142.1 - 0.045 12.9 1.8 2.1 7.4 0.3 2.6 1 1 1 2 2 2 0 G-protein alpha subunit AAA_29 PF13555.6 AET41142.1 - 0.046 13.5 0.1 0.15 11.8 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_16 PF13191.6 AET41142.1 - 0.071 13.5 0.1 0.11 12.9 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain DUF815 PF05673.13 AET41142.1 - 0.075 12.2 0.0 0.19 10.9 0.0 1.6 1 1 0 2 2 2 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 AET41142.1 - 0.091 13.3 0.2 0.31 11.6 0.2 2.0 1 1 0 1 1 1 0 ABC transporter TniB PF05621.11 AET41142.1 - 0.16 11.3 0.0 0.3 10.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein VTC PF09359.10 AET41143.1 - 2.5e-88 296.0 0.0 4.3e-88 295.3 0.0 1.4 1 0 0 1 1 1 1 VTC domain SPX PF03105.19 AET41143.1 - 2.8e-11 44.0 24.2 0.00042 20.4 2.1 4.2 2 1 2 4 4 4 3 SPX domain DUF202 PF02656.15 AET41143.1 - 1.8e-10 41.1 5.2 1.8e-10 41.1 5.2 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF202) MtrG PF04210.13 AET41143.1 - 0.19 11.6 0.2 1.3 9.0 0.0 2.5 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G Peptidase_C48 PF02902.19 AET41144.1 - 2.4e-36 125.6 0.8 5.8e-36 124.4 0.8 1.6 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain APOBEC4_like PF18774.1 AET41144.1 - 0.018 15.0 0.1 0.058 13.3 0.1 1.8 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase Propeptide_C1 PF08127.13 AET41144.1 - 0.52 10.2 2.2 2.2 8.3 0.4 2.8 3 0 0 3 3 3 0 Peptidase family C1 propeptide MutS_V PF00488.21 AET41145.1 - 2e-57 194.3 0.2 5.8e-57 192.8 0.2 1.8 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 AET41145.1 - 3.8e-26 92.5 7.5 3.8e-26 92.5 7.5 2.5 2 1 0 2 2 2 1 MutS domain III MutS_II PF05188.17 AET41145.1 - 4e-15 56.3 0.1 1.3e-14 54.6 0.1 2.0 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 AET41145.1 - 4e-14 52.7 0.5 4.4e-13 49.4 0.2 2.7 2 0 0 2 2 2 1 MutS family domain IV Helicase_C PF00271.31 AET41145.1 - 0.091 13.1 0.0 0.48 10.8 0.0 2.3 1 0 0 1 1 1 0 Helicase conserved C-terminal domain ApoLp-III PF07464.11 AET41145.1 - 0.53 10.4 0.0 0.53 10.4 0.0 2.6 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) SIR2 PF02146.17 AET41146.1 - 1.3e-49 168.5 0.0 1.8e-49 168.0 0.0 1.2 1 0 0 1 1 1 1 Sir2 family Clat_adaptor_s PF01217.20 AET41147.1 - 4.4e-17 62.3 0.7 5.8e-17 61.9 0.7 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Bromo_TP PF07524.13 AET41148.1 - 1e-05 25.4 0.1 2.7e-05 24.1 0.0 1.7 2 0 0 2 2 2 1 Bromodomain associated TFIID-31kDa PF02291.15 AET41148.1 - 0.057 13.5 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit NUC173 PF08161.12 AET41149.1 - 7.1e-74 247.9 0.7 2e-70 236.6 0.1 4.2 4 0 0 4 4 4 1 NUC173 domain UME PF08064.13 AET41149.1 - 0.00038 20.3 12.0 0.076 12.9 0.5 5.1 4 1 0 4 4 4 2 UME (NUC010) domain DIL PF01843.19 AET41149.1 - 0.063 13.6 0.3 0.37 11.1 0.0 2.6 2 0 0 2 2 2 0 DIL domain RTP1_C1 PF10363.9 AET41149.1 - 0.089 13.0 0.7 30 4.8 0.0 3.6 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 AET41149.1 - 0.17 12.3 0.3 31 5.2 0.0 4.4 4 0 0 4 4 4 0 HEAT repeat Ribosomal_S16 PF00886.19 AET41150.1 - 9.5e-25 86.4 0.1 1.3e-24 86.0 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S16 PDR_assoc PF08370.11 AET41150.1 - 0.053 13.3 0.0 0.096 12.4 0.0 1.4 1 0 0 1 1 1 0 Plant PDR ABC transporter associated zf-TFIIIC PF12660.7 AET41153.1 - 1.5e-08 34.5 0.0 3.5e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex ANAPC4_WD40 PF12894.7 AET41153.1 - 0.0032 17.7 0.0 0.033 14.5 0.0 2.8 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain NPC1_N PF16414.5 AET41154.1 - 3.4e-77 259.3 16.8 5.4e-77 258.7 16.8 1.3 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.18 AET41154.1 - 1.6e-56 191.9 22.1 2.8e-32 111.7 1.1 2.3 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 AET41154.1 - 4.6e-40 137.0 8.5 4.6e-40 137.0 8.5 3.0 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Folate_rec PF03024.14 AET41154.1 - 0.00017 21.5 3.1 0.00049 20.0 3.1 1.7 1 0 0 1 1 1 1 Folate receptor family TMEM18 PF14770.6 AET41154.1 - 0.12 12.3 0.1 0.12 12.3 0.1 3.2 4 1 1 5 5 5 0 Transmembrane protein 18 PPR_2 PF13041.6 AET41155.1 - 1.6e-14 53.8 7.5 2e-06 27.9 0.4 4.3 4 0 0 4 4 4 2 PPR repeat family PPR_3 PF13812.6 AET41155.1 - 3.5e-08 33.4 1.4 0.0029 17.6 0.3 3.2 3 0 0 3 3 3 2 Pentatricopeptide repeat domain PPR_long PF17177.4 AET41155.1 - 0.0003 20.2 0.0 0.23 10.8 0.0 2.4 2 0 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 AET41155.1 - 0.0045 16.7 1.4 1.3 8.7 0.0 3.1 2 1 0 2 2 2 2 PPR repeat PPR PF01535.20 AET41155.1 - 0.09 13.1 8.6 2.1 8.8 0.0 5.3 5 0 0 5 5 5 0 PPR repeat Pil1 PF13805.6 AET41156.1 - 5.8e-122 406.3 0.0 7.2e-122 406.0 0.0 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 DUF2385 PF09539.10 AET41156.1 - 0.15 12.6 1.7 1.6 9.3 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2385) Nop10p PF04135.12 AET41156.1 - 0.46 10.6 3.9 4.6 7.4 0.1 2.4 2 0 0 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family ThiF PF00899.21 AET41157.1 - 8.8e-12 44.9 0.0 4.3e-05 23.0 2.5 2.3 2 1 0 2 2 2 2 ThiF family DEAD PF00270.29 AET41158.1 - 1.5e-40 138.8 0.0 7.1e-40 136.6 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET41158.1 - 2.6e-23 82.5 0.0 2.3e-22 79.4 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 AET41158.1 - 2.5e-15 56.5 0.0 5e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 AET41158.1 - 4.2e-05 23.6 2.4 0.00044 20.3 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 AET41158.1 - 0.00037 19.8 0.0 0.00037 19.8 0.0 2.3 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase PseudoU_synth_1 PF01416.20 AET41159.1 - 4.1e-29 101.2 0.0 2.1e-26 92.5 0.0 2.5 2 1 0 2 2 2 2 tRNA pseudouridine synthase SinI PF08671.10 AET41159.1 - 0.066 13.0 0.1 0.2 11.5 0.0 1.9 2 0 0 2 2 2 0 Anti-repressor SinI DUF2312 PF10073.9 AET41159.1 - 0.11 12.1 2.1 1.7 8.3 2.4 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) EAP30 PF04157.16 AET41160.1 - 1.3e-56 191.5 0.0 1.5e-56 191.4 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Hat1_N PF10394.9 AET41161.1 - 7.4e-44 149.8 0.8 7.4e-44 149.8 0.8 1.9 2 0 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 AET41161.1 - 0.0016 18.7 0.0 0.0031 17.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Tox-ODYAM1 PF15642.6 AET41162.1 - 0.058 12.4 11.7 0.07 12.1 11.7 1.1 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus MmgE_PrpD PF03972.14 AET41163.1 - 3.6e-147 490.5 0.0 4.3e-147 490.2 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family PPI_Ypi1 PF07491.11 AET41164.1 - 2.6e-24 84.8 4.3 5.5e-24 83.8 4.3 1.5 1 0 0 1 1 1 1 Protein phosphatase inhibitor Dehydrin PF00257.19 AET41164.1 - 0.00067 20.3 3.6 0.00085 19.9 3.6 1.4 1 1 0 1 1 1 1 Dehydrin Big_4 PF07532.11 AET41164.1 - 0.83 9.4 2.8 2.2 8.1 2.8 1.7 1 1 0 1 1 1 0 Bacterial Ig-like domain (group 4) JAB PF01398.21 AET41165.1 - 6.2e-32 110.0 0.2 1.4e-31 108.9 0.2 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 AET41165.1 - 1.3e-12 48.1 1.2 1.3e-12 48.1 1.2 1.8 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 AET41165.1 - 2.3e-07 30.6 0.0 3.8e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 AET41165.1 - 0.031 14.3 0.6 0.11 12.5 0.0 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0172) UCH PF00443.29 AET41166.1 - 2.9e-18 66.3 1.8 5.9e-18 65.3 1.8 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 AET41166.1 - 3.2e-10 40.2 0.0 7.3e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein Peptidase_M24 PF00557.24 AET41167.1 - 1.3e-61 208.0 0.0 1.7e-61 207.5 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 AET41167.1 - 5.3e-22 77.8 0.0 2e-21 76.0 0.0 2.0 2 0 0 2 2 2 1 Aminopeptidase P, N-terminal domain PITH PF06201.13 AET41168.1 - 8e-37 126.8 0.2 1e-36 126.4 0.2 1.1 1 0 0 1 1 1 1 PITH domain ALAD PF00490.21 AET41169.1 - 3e-115 384.7 0.0 3.6e-115 384.5 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Snf7 PF03357.21 AET41170.1 - 9.2e-34 116.5 7.0 1.2e-33 116.1 7.0 1.1 1 0 0 1 1 1 1 Snf7 PALP PF00291.25 AET41171.1 - 6.5e-62 209.6 0.0 8.3e-62 209.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 AET41171.1 - 6.9e-18 64.8 0.2 1.3e-11 44.8 0.1 2.6 2 0 0 2 2 2 2 CBS domain GHMP_kinases_C PF08544.13 AET41171.1 - 0.018 15.4 0.1 1.4 9.3 0.1 2.8 2 0 0 2 2 2 0 GHMP kinases C terminal ComZ PF10815.8 AET41172.1 - 0.00098 19.1 0.3 0.002 18.1 0.3 1.5 1 0 0 1 1 1 1 ComZ TFIIS_M PF07500.14 AET41173.1 - 2.4e-27 95.6 0.2 2.4e-27 95.6 0.2 2.3 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 AET41173.1 - 1.2e-17 63.5 6.7 2.3e-17 62.5 6.7 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 AET41173.1 - 4.5e-10 39.4 2.7 1.2e-09 38.0 2.7 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain SR-25 PF10500.9 AET41173.1 - 0.0071 16.0 2.9 0.012 15.2 2.9 1.4 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein E3_UbLigase_R4 PF13764.6 AET41173.1 - 0.014 13.6 1.2 0.018 13.2 1.2 1.1 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 COMPASS-Shg1 PF05205.12 AET41173.1 - 0.26 12.0 4.9 0.4 11.4 0.9 2.9 2 1 1 3 3 3 0 COMPASS (Complex proteins associated with Set1p) component shg1 TnpW PF14202.6 AET41173.1 - 0.57 10.1 2.6 0.39 10.6 0.2 2.0 2 0 0 2 2 2 0 Transposon-encoded protein TnpW HypA PF01155.19 AET41173.1 - 1.3 9.0 5.8 0.56 10.3 2.2 2.1 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF1104 PF06518.11 AET41173.1 - 2.5 8.5 7.1 2.9 8.3 0.7 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1104) RRM_1 PF00076.22 AET41174.1 - 1.2e-19 69.9 0.0 2e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 AET41174.1 - 1.4e-11 43.8 0.3 3.7e-11 42.4 0.3 1.8 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal CSTF2_hinge PF14327.6 AET41174.1 - 3.9e-09 36.9 1.5 3.9e-09 36.9 1.5 1.6 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_occluded PF16842.5 AET41174.1 - 0.0017 18.2 0.0 0.0031 17.4 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_7 PF16367.5 AET41174.1 - 0.18 12.0 0.0 0.64 10.2 0.0 1.9 1 1 0 1 1 1 0 RNA recognition motif CSTF2_hinge PF14327.6 AET41175.1 - 2.2e-21 76.1 3.9 5.4e-21 74.8 2.6 2.3 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 CSTF_C PF14304.6 AET41175.1 - 2.5e-07 30.2 2.4 6.4e-07 28.9 2.4 1.7 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal DUF4149 PF13664.6 AET41177.1 - 0.17 12.2 2.3 0.7 10.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) PWI PF01480.17 AET41179.1 - 0.0014 18.9 0.2 0.0039 17.5 0.2 1.8 1 0 0 1 1 1 1 PWI domain PALP PF00291.25 AET41180.1 - 1.4e-70 238.1 0.1 1.6e-70 237.9 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme AlaDh_PNT_C PF01262.21 AET41180.1 - 0.038 13.3 0.1 0.038 13.3 0.1 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain CTP_transf_like PF01467.26 AET41181.1 - 2.1e-28 99.3 0.0 3e-28 98.8 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like RCC1 PF00415.18 AET41182.1 - 3.3e-23 82.1 14.2 0.0015 19.1 0.2 6.6 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 AET41182.1 - 6.7e-17 60.8 28.2 3.1e-08 33.2 0.6 5.6 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat Exo_endo_phos PF03372.23 AET41183.1 - 2.2e-22 79.8 0.0 3.5e-22 79.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.7 AET41183.1 - 1.2e-10 41.4 9.7 5.2e-07 29.9 2.0 3.1 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AET41183.1 - 2.9e-09 36.6 12.1 1.6e-05 24.5 6.1 2.5 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 AET41183.1 - 0.00051 20.2 4.3 1.7 9.5 0.1 4.5 4 0 0 4 4 4 2 Leucine Rich Repeat GPCR_chapero_1 PF11904.8 AET41183.1 - 0.22 10.9 1.7 0.17 11.3 0.1 1.6 2 0 0 2 2 2 0 GPCR-chaperone LRR_6 PF13516.6 AET41183.1 - 1.6 8.9 3.8 3.4 7.9 0.3 2.6 2 0 0 2 2 2 0 Leucine Rich repeat PMT PF02366.18 AET41184.1 - 1.6e-94 316.1 14.0 1.6e-94 316.1 14.0 2.1 3 1 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 AET41184.1 - 1.4e-57 194.5 12.2 1.4e-57 194.5 12.2 2.3 2 1 1 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 AET41184.1 - 1.3e-26 93.6 0.5 2.1e-26 92.9 0.5 1.2 1 0 0 1 1 1 1 MIR domain LDB19 PF13002.7 AET41185.1 - 9.1e-71 237.6 0.0 1.4e-70 236.9 0.0 1.3 1 0 0 1 1 1 1 Arrestin_N terminal like RasGEF PF00617.19 AET41186.1 - 2.4e-40 138.6 3.2 2.4e-40 138.6 3.2 3.2 4 0 0 4 4 4 1 RasGEF domain RasGEF_N PF00618.20 AET41186.1 - 9.4e-15 54.7 0.8 8.1e-14 51.7 0.2 2.8 2 0 0 2 2 2 1 RasGEF N-terminal motif Pkinase PF00069.25 AET41188.1 - 4.7e-64 216.3 0.0 6.7e-64 215.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET41188.1 - 1.4e-31 109.7 0.0 2.2e-31 109.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AET41188.1 - 0.00036 19.6 0.5 0.00073 18.6 0.2 1.6 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 AET41188.1 - 0.0048 16.3 0.0 0.0079 15.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AET41188.1 - 0.045 13.7 0.1 0.16 11.9 0.1 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family PIF1 PF05970.14 AET41189.1 - 1.7e-54 185.4 0.1 1e-51 176.3 0.1 2.3 1 1 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 AET41189.1 - 1.2e-21 77.3 0.0 2.6e-21 76.2 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AET41189.1 - 4.6e-07 30.3 0.0 9.5e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 AET41189.1 - 9.4e-05 22.0 0.1 0.00027 20.5 0.1 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region Herpes_Helicase PF02689.14 AET41189.1 - 0.0001 20.4 0.1 0.00033 18.7 0.0 1.7 2 0 0 2 2 2 1 Helicase AAA_22 PF13401.6 AET41189.1 - 0.00015 22.0 0.1 0.0061 16.8 0.1 2.9 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 AET41189.1 - 0.00051 20.5 0.1 0.0012 19.3 0.1 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AET41189.1 - 0.0046 17.0 0.9 0.041 13.9 0.2 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 AET41189.1 - 0.015 15.0 0.4 5.3 6.7 0.2 2.9 2 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 AET41189.1 - 0.022 15.2 0.3 0.078 13.3 0.2 1.9 1 1 0 1 1 1 0 AAA ATPase domain UvrD_C_2 PF13538.6 AET41189.1 - 0.036 13.9 0.4 0.19 11.6 0.4 2.2 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain PhoH PF02562.16 AET41189.1 - 0.042 13.3 0.0 0.1 12.0 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.12 AET41189.1 - 0.044 13.7 0.1 0.089 12.7 0.1 1.6 1 0 0 1 1 1 0 NACHT domain DUF2075 PF09848.9 AET41189.1 - 0.052 12.8 0.2 0.31 10.2 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) TrwB_AAD_bind PF10412.9 AET41189.1 - 0.068 12.1 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain T2SSE PF00437.20 AET41189.1 - 0.081 12.0 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein RNA_helicase PF00910.22 AET41189.1 - 0.13 12.7 0.0 0.62 10.5 0.0 2.1 1 1 0 1 1 1 0 RNA helicase Helicase_RecD PF05127.14 AET41189.1 - 0.18 11.7 1.0 1.3 8.8 1.0 2.1 1 1 0 1 1 1 0 Helicase Ribosomal_L12_N PF16320.5 AET41189.1 - 0.18 11.5 0.3 0.45 10.3 0.3 1.6 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain GCR1_C PF12550.8 AET41190.1 - 1.6e-12 47.6 0.5 3.1e-12 46.6 0.5 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes SelP_N PF04592.14 AET41190.1 - 0.14 11.6 15.0 0.03 13.7 10.0 2.0 2 0 0 2 2 2 0 Selenoprotein P, N terminal region ALF PF03752.13 AET41190.1 - 0.16 12.0 0.4 0.34 10.9 0.4 1.5 1 0 0 1 1 1 0 Short repeats of unknown function Ribosomal_L1 PF00687.21 AET41191.1 - 4.2e-35 121.3 4.8 1.1e-34 120.0 4.8 1.8 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF4263 PF14082.6 AET41191.1 - 0.38 11.0 4.6 0.13 12.6 0.9 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4263) Elf1 PF05129.13 AET41192.1 - 1.1e-29 102.3 3.1 1.4e-29 102.0 3.1 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Ribosomal_L37ae PF01780.19 AET41192.1 - 0.12 12.5 1.7 0.27 11.3 1.7 1.5 1 0 0 1 1 1 0 Ribosomal L37ae protein family zf-C2H2_2 PF12756.7 AET41192.1 - 0.25 11.7 3.2 3.6 8.0 0.4 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) COX5A PF02284.16 AET41193.1 - 8.9e-39 131.6 1.1 1.2e-38 131.2 1.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va DUF488 PF04343.13 AET41193.1 - 0.02 15.5 0.3 0.092 13.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF488 DUF4286 PF14114.6 AET41193.1 - 0.035 14.6 0.2 11 6.6 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4286) VPS28 PF03997.12 AET41193.1 - 0.04 13.6 0.1 0.094 12.4 0.1 1.6 1 1 0 1 1 1 0 VPS28 protein GerPC PF10737.9 AET41193.1 - 0.048 13.7 0.3 1.5 8.9 0.1 2.0 2 0 0 2 2 2 0 Spore germination protein GerPC Calcipressin PF04847.12 AET41194.1 - 4.5e-11 42.8 0.2 6.3e-11 42.4 0.2 1.4 1 1 0 1 1 1 1 Calcipressin SUI1 PF01253.22 AET41195.1 - 3.4e-20 72.4 0.9 7.3e-20 71.3 0.9 1.6 1 0 0 1 1 1 1 Translation initiation factor SUI1 Svf1 PF08622.10 AET41195.1 - 0.047 13.7 0.2 0.064 13.3 0.2 1.4 1 1 0 1 1 1 0 Svf1-like N-terminal lipocalin domain TPR_17 PF13431.6 AET41196.1 - 0.03 14.7 3.8 0.58 10.7 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Lipase_3 PF01764.25 AET41197.1 - 2.8e-28 98.6 0.0 4e-28 98.1 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 AET41197.1 - 0.00019 20.8 0.0 0.0003 20.1 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 AET41197.1 - 0.0043 17.2 0.1 0.0074 16.4 0.1 1.3 1 0 0 1 1 1 1 Thioesterase domain PMT PF02366.18 AET41198.1 - 2.2e-65 220.6 13.4 2.2e-65 220.6 13.4 1.8 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 AET41198.1 - 3.9e-51 173.5 12.6 3.9e-51 173.5 12.6 2.1 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 AET41198.1 - 1.3e-09 38.2 0.0 2.6e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 AET41198.1 - 0.00061 20.0 8.7 0.00061 20.0 8.7 3.4 3 2 1 4 4 4 1 Dolichyl-phosphate-mannose-protein mannosyltransferase WD40 PF00400.32 AET41199.1 - 4.4e-33 112.8 9.9 2.9e-05 24.8 0.0 9.8 10 0 0 10 10 10 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET41199.1 - 7e-09 35.9 5.0 0.7 10.2 0.1 7.2 6 3 1 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 AET41199.1 - 9.1e-05 22.5 0.0 0.0067 16.5 0.0 3.7 4 0 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 AET41199.1 - 0.00074 18.9 0.0 0.0083 15.5 0.0 2.4 3 0 0 3 3 3 1 WD40-like domain ILVD_EDD PF00920.21 AET41200.1 - 1.1e-208 694.0 0.0 1.3e-208 693.9 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family CTP_transf_like PF01467.26 AET41201.1 - 3.1e-34 118.2 0.0 5.1e-34 117.5 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like CTNNBL PF08216.11 AET41201.1 - 0.0079 16.4 0.6 0.017 15.3 0.6 1.5 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear Trefoil PF00088.18 AET41201.1 - 0.031 14.2 0.1 0.057 13.3 0.1 1.4 1 0 0 1 1 1 0 Trefoil (P-type) domain Rhodanese PF00581.20 AET41202.1 - 3.3e-09 37.2 0.0 4.3e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain AA_kinase PF00696.28 AET41202.1 - 0.07 12.7 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Amino acid kinase family Mei4 PF13971.6 AET41202.1 - 0.08 12.4 0.0 0.095 12.2 0.0 1.1 1 0 0 1 1 1 0 Meiosis-specific protein Mei4 Rotamase PF00639.21 AET41203.1 - 1.3e-24 86.9 0.0 1.8e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 AET41203.1 - 4.6e-20 72.3 0.0 6.6e-20 71.8 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 AET41203.1 - 2.6e-08 33.8 0.1 3.9e-08 33.3 0.1 1.3 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.6 AET41203.1 - 8.9e-06 26.5 0.0 1.3e-05 26.0 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain RNaseH_C PF09293.10 AET41203.1 - 0.01 16.2 0.1 0.015 15.6 0.1 1.2 1 0 0 1 1 1 1 T4 RNase H, C terminal Glyco_hyd_101C PF17451.2 AET41203.1 - 0.029 14.7 0.2 0.058 13.7 0.1 1.5 2 0 0 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain FKBP_C PF00254.28 AET41203.1 - 0.13 12.6 0.1 0.29 11.5 0.1 1.5 1 1 0 1 1 1 0 FKBP-type peptidyl-prolyl cis-trans isomerase FTHFS PF01268.19 AET41204.1 - 5.3e-247 820.5 0.3 6.7e-247 820.1 0.3 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 AET41204.1 - 7.1e-60 200.9 0.3 2.3e-59 199.3 0.1 2.0 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 AET41204.1 - 1.3e-36 125.4 0.1 3e-36 124.2 0.1 1.7 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain AdoHcyase_NAD PF00670.21 AET41204.1 - 0.026 14.6 2.8 2.9 7.9 0.7 3.2 2 1 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain CbiA PF01656.23 AET41204.1 - 0.042 13.9 0.0 0.21 11.7 0.0 2.2 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain 4HBT_3 PF13622.6 AET41205.1 - 3.1e-24 86.6 0.0 5.5e-24 85.8 0.0 1.3 1 1 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 AET41205.1 - 6.4e-22 77.8 0.2 3.3e-14 52.9 0.2 3.1 2 1 0 2 2 2 2 Acyl-CoA thioesterase Zeta_toxin PF06414.12 AET41206.1 - 0.0016 17.7 0.0 0.0026 17.1 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 AET41206.1 - 0.0031 17.9 0.0 0.006 17.0 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain SRP54 PF00448.22 AET41206.1 - 0.0053 16.4 0.0 0.012 15.2 0.0 1.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 AET41206.1 - 0.0081 16.5 0.0 0.016 15.6 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA PF00004.29 AET41206.1 - 0.011 16.2 0.0 0.019 15.4 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 AET41206.1 - 0.024 14.8 0.0 0.038 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 AET41206.1 - 0.035 14.1 0.0 0.06 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AET41206.1 - 0.037 14.3 0.0 0.17 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 AET41206.1 - 0.056 13.4 0.0 0.088 12.8 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ATPase_2 PF01637.18 AET41206.1 - 0.077 12.9 0.0 0.63 9.9 0.0 2.0 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Sigma54_activ_2 PF14532.6 AET41206.1 - 0.14 12.3 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_11 PF13086.6 AET41206.1 - 0.19 11.5 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Mer2 PF09074.10 AET41207.1 - 2.1e-31 109.3 7.5 2.6e-31 109.0 7.5 1.1 1 0 0 1 1 1 1 Mer2 Occludin_ELL PF07303.13 AET41207.1 - 0.035 14.8 5.8 0.37 11.6 0.7 2.3 2 0 0 2 2 2 0 Occludin homology domain Viral_P18 PF04521.13 AET41207.1 - 0.082 12.7 0.2 0.082 12.7 0.2 1.7 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein DUF3206 PF11472.8 AET41207.1 - 0.14 12.1 1.1 0.32 11.0 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3206) Sec34 PF04136.15 AET41207.1 - 0.18 11.7 8.2 0.23 11.3 0.6 2.3 2 0 0 2 2 2 0 Sec34-like family CENP-H PF05837.12 AET41207.1 - 0.41 11.1 6.6 4.8 7.6 1.6 2.3 2 0 0 2 2 2 0 Centromere protein H (CENP-H) DUF2203 PF09969.9 AET41207.1 - 0.55 11.0 5.0 0.75 10.5 0.6 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF1664 PF07889.12 AET41207.1 - 0.72 9.9 8.4 2.7 8.1 2.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 AET41207.1 - 0.96 9.0 9.9 0.28 10.7 1.5 2.1 1 1 1 2 2 2 0 Exonuclease VII, large subunit Nsp1_C PF05064.13 AET41207.1 - 6.9 6.5 11.7 0.27 11.0 1.9 2.6 2 1 0 2 2 2 0 Nsp1-like C-terminal region LSM PF01423.22 AET41208.1 - 3.1e-12 46.0 0.1 5.3e-12 45.2 0.0 1.4 2 0 0 2 2 2 1 LSM domain Aldolase_II PF00596.21 AET41209.1 - 4.1e-44 150.7 0.0 4.9e-44 150.5 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain DUF2202 PF09968.9 AET41209.1 - 0.054 13.3 0.0 0.083 12.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein domain (DUF2202) 3-HAO PF06052.12 AET41210.1 - 8.9e-67 223.4 0.0 1e-66 223.2 0.0 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 AET41210.1 - 3.9e-06 26.5 0.0 5.9e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 AET41210.1 - 0.00065 19.3 0.0 0.0009 18.9 0.0 1.2 1 0 0 1 1 1 1 Cupin zf-B_box PF00643.24 AET41210.1 - 0.034 14.3 3.8 0.04 14.1 0.6 2.2 2 0 0 2 2 2 0 B-box zinc finger Mvb12 PF09452.10 AET41211.1 - 7.9e-32 109.6 0.4 8.8e-32 109.4 0.4 1.0 1 0 0 1 1 1 1 ESCRT-I subunit Mvb12 CSN7a_helixI PF18392.1 AET41211.1 - 0.047 13.6 0.2 0.069 13.1 0.2 1.2 1 0 0 1 1 1 0 COP9 signalosome complex subunit 7a helix I domain DUF1759 PF03564.15 AET41211.1 - 0.068 13.1 0.0 0.076 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) ETF PF01012.21 AET41212.1 - 3.4e-38 131.3 0.4 4.3e-38 131.0 0.4 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Hydrolase PF00702.26 AET41213.1 - 1.3e-19 71.3 2.5 1.7e-19 70.9 1.1 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 AET41213.1 - 1.9e-16 61.0 0.0 3.6e-16 60.1 0.0 1.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AET41213.1 - 1.5e-10 41.3 0.5 3.9e-09 36.6 0.0 2.4 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AET41213.1 - 3.8e-05 23.8 0.2 0.035 14.2 0.1 2.4 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 AET41213.1 - 4.9e-05 22.8 0.0 8.8e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Putative Phosphatase S6PP PF05116.13 AET41213.1 - 0.00073 19.1 0.0 0.011 15.3 0.0 2.1 2 0 0 2 2 2 1 Sucrose-6F-phosphate phosphohydrolase DUF705 PF05152.12 AET41213.1 - 0.071 12.6 0.0 0.18 11.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF705) Thioredoxin PF00085.20 AET41214.1 - 7.5e-29 99.7 0.2 8.8e-29 99.5 0.2 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 AET41214.1 - 1.3e-05 25.4 0.1 4.2e-05 23.8 0.1 1.7 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 AET41214.1 - 3.3e-05 24.3 0.4 0.00022 21.7 0.4 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 AET41214.1 - 3.8e-05 23.6 0.1 4.3e-05 23.4 0.1 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AET41214.1 - 0.00016 21.4 0.0 0.00017 21.3 0.0 1.2 1 0 0 1 1 1 1 Redoxin Thioredoxin_9 PF14595.6 AET41214.1 - 0.00085 19.1 0.1 0.001 18.9 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin DIM1 PF02966.16 AET41214.1 - 0.0053 16.5 0.2 0.006 16.4 0.2 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 Phosducin PF02114.16 AET41214.1 - 0.0061 15.5 0.1 0.0069 15.4 0.1 1.0 1 0 0 1 1 1 1 Phosducin Thioredoxin_7 PF13899.6 AET41214.1 - 0.01 16.0 0.1 0.02 15.1 0.1 1.6 1 1 0 1 1 1 0 Thioredoxin-like Glutaredoxin PF00462.24 AET41214.1 - 0.019 15.2 0.0 0.031 14.5 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin OST3_OST6 PF04756.13 AET41214.1 - 0.03 13.7 0.0 0.034 13.5 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family TraF PF13728.6 AET41214.1 - 0.042 13.7 0.0 0.057 13.2 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein DUF4290 PF14123.6 AET41214.1 - 0.073 12.6 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4290) Utp11 PF03998.13 AET41216.1 - 5.9e-69 232.7 25.4 6.9e-69 232.5 25.4 1.0 1 0 0 1 1 1 1 Utp11 protein PAS_10 PF13596.6 AET41216.1 - 0.018 15.7 1.0 0.018 15.7 1.0 2.6 2 1 0 2 2 2 0 PAS domain TfuA PF07812.12 AET41216.1 - 0.029 14.1 0.0 0.057 13.1 0.0 1.6 1 1 0 1 1 1 0 TfuA-like protein SLATT_5 PF18160.1 AET41216.1 - 0.059 12.7 0.2 0.13 11.6 0.2 1.6 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 ADH_N PF08240.12 AET41217.1 - 6.2e-30 103.3 0.5 1.4e-29 102.2 0.5 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AET41217.1 - 2.1e-25 89.2 0.6 3.4e-25 88.5 0.6 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AET41217.1 - 1.5e-06 29.3 0.0 2.8e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Pkinase PF00069.25 AET41218.1 - 4.6e-74 249.1 0.0 8.1e-74 248.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET41218.1 - 2.3e-39 135.2 0.5 4.7e-39 134.2 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 AET41218.1 - 0.0051 16.2 0.0 0.01 15.2 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Mrr_N PF14338.6 AET41218.1 - 0.008 16.3 0.0 0.098 12.8 0.0 2.8 2 0 0 2 2 2 1 Mrr N-terminal domain Kdo PF06293.14 AET41218.1 - 0.013 14.9 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 AET41218.1 - 0.033 13.8 0.1 0.096 12.3 0.1 1.8 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 AET41218.1 - 0.064 13.2 0.0 0.21 11.5 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Peptidase_M18 PF02127.15 AET41219.1 - 6e-138 460.3 0.0 7.2e-138 460.0 0.0 1.1 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Sprouty PF05210.13 AET41220.1 - 0.065 13.6 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Sprouty protein (Spry) YtfJ_HI0045 PF09695.10 AET41220.1 - 0.14 11.8 0.0 0.22 11.2 0.0 1.3 1 1 0 1 1 1 0 Bacterial protein of unknown function (YtfJ_HI0045) SIS PF01380.22 AET41221.1 - 6.3e-63 210.5 0.1 1.3e-32 112.4 0.2 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 AET41221.1 - 4.5e-16 59.3 0.0 9.1e-16 58.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 AET41221.1 - 8.8e-11 41.8 0.0 1.7e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 AET41221.1 - 1.1e-06 27.7 0.1 1.9e-06 27.0 0.1 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II MYO10_CC PF16735.5 AET41221.1 - 0.0015 18.6 1.4 4.7 7.4 1.3 3.3 3 0 0 3 3 3 2 Unconventional myosin-X coiled coil domain GATase_2 PF00310.21 AET41221.1 - 0.19 10.4 0.0 0.36 9.5 0.0 1.4 1 1 0 1 1 1 0 Glutamine amidotransferases class-II Aminotran_1_2 PF00155.21 AET41223.1 - 3.3e-75 253.5 0.0 3.8e-75 253.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Macro_2 PF14519.6 AET41224.1 - 2.5e-67 227.2 0.0 3e-67 226.9 0.0 1.0 1 0 0 1 1 1 1 Macro-like domain Macro PF01661.21 AET41224.1 - 0.00037 20.5 0.0 0.00064 19.7 0.0 1.4 1 0 0 1 1 1 1 Macro domain MFS_1 PF07690.16 AET41225.1 - 7.6e-36 123.8 32.7 3.7e-35 121.5 32.7 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AET41225.1 - 1.2e-11 44.1 7.4 1.2e-11 44.1 7.4 2.5 3 0 0 3 3 3 1 Sugar (and other) transporter OATP PF03137.20 AET41225.1 - 0.73 8.0 16.1 0.089 11.1 1.6 3.2 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Peptidase_M41 PF01434.18 AET41226.1 - 5.7e-65 218.7 0.0 1.3e-64 217.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 AET41226.1 - 2.6e-42 144.4 0.0 7.5e-42 142.9 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AET41226.1 - 1.4e-15 56.8 0.0 6.2e-15 54.7 0.1 2.2 2 0 0 2 2 2 1 AAA+ lid domain FtsH_ext PF06480.15 AET41226.1 - 1.1e-06 29.0 0.2 3.2e-06 27.5 0.2 1.9 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.14 AET41226.1 - 0.00086 19.3 0.1 0.0052 16.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 AET41226.1 - 0.0034 16.7 0.0 0.0067 15.7 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 AET41226.1 - 0.0068 16.2 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_17 PF13207.6 AET41226.1 - 0.0072 16.7 0.0 0.0072 16.7 0.0 3.2 3 1 0 3 3 3 1 AAA domain AAA_2 PF07724.14 AET41226.1 - 0.016 15.4 1.5 0.032 14.3 0.0 2.3 2 1 0 2 2 1 0 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 AET41226.1 - 0.018 15.3 0.1 0.77 10.0 0.1 2.9 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 AET41226.1 - 0.021 15.2 2.7 0.067 13.6 0.2 2.9 2 1 0 2 2 2 0 AAA ATPase domain IstB_IS21 PF01695.17 AET41226.1 - 0.036 13.8 0.0 0.096 12.4 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 AET41226.1 - 0.066 13.4 0.9 0.63 10.2 0.0 2.8 3 0 0 3 3 2 0 AAA domain RP-C_C PF11800.8 AET41226.1 - 0.29 11.2 4.8 0.57 10.2 4.8 1.5 1 0 0 1 1 1 0 Replication protein C C-terminal region AAA_18 PF13238.6 AET41226.1 - 0.49 11.0 2.5 1.5 9.3 0.0 3.0 2 1 0 3 3 3 0 AAA domain DUF4337 PF14235.6 AET41226.1 - 1 9.5 6.6 2.8 8.0 6.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF4407 PF14362.6 AET41226.1 - 1.7 8.0 4.6 3.2 7.0 4.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SMBP PF16785.5 AET41226.1 - 5 7.4 6.7 3 8.1 3.6 2.3 2 0 0 2 2 2 0 Small metal-binding protein Presenilin PF01080.17 AET41226.1 - 6.7 5.4 8.0 9.5 4.9 8.0 1.1 1 0 0 1 1 1 0 Presenilin CRC_subunit PF08624.10 AET41227.1 - 1.1e-52 178.1 0.1 2e-52 177.2 0.1 1.5 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit YL1 PF05764.13 AET41227.1 - 0.085 13.0 18.0 0.15 12.2 18.0 1.4 1 0 0 1 1 1 0 YL1 nuclear protein Nop14 PF04147.12 AET41227.1 - 0.16 10.1 19.1 0.2 9.8 19.1 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 AET41227.1 - 1.4 8.2 19.4 1.8 7.8 19.4 1.1 1 0 0 1 1 1 0 BUD22 TFIIF_alpha PF05793.12 AET41227.1 - 2.7 6.5 21.3 3.8 6.0 21.3 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SDA1 PF05285.12 AET41227.1 - 6.9 6.0 22.0 10 5.5 22.0 1.2 1 0 0 1 1 1 0 SDA1 WD40 PF00400.32 AET41228.1 - 4.7e-15 55.7 26.2 0.34 11.9 0.1 10.4 10 0 0 10 10 10 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET41228.1 - 1.8e-10 40.9 6.2 0.0055 17.0 0.1 7.0 5 2 2 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AET41228.1 - 0.00021 20.8 0.2 0.0043 16.4 0.1 2.4 2 0 0 2 2 2 1 WD40-like domain RAB3GAP2_N PF14655.6 AET41228.1 - 0.00072 18.9 0.0 0.0015 17.9 0.0 1.5 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Nup160 PF11715.8 AET41228.1 - 0.0085 14.8 0.8 0.071 11.7 0.0 2.5 2 1 0 2 2 2 1 Nucleoporin Nup120/160 UTP15_C PF09384.10 AET41229.1 - 2.5e-44 150.5 0.1 5.1e-44 149.5 0.1 1.5 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 AET41229.1 - 3.5e-16 59.3 3.2 0.00081 20.2 0.0 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET41229.1 - 2.6e-05 24.4 0.0 0.021 15.1 0.0 4.0 1 1 3 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain CPSF_A PF03178.15 AET41229.1 - 0.09 12.1 0.0 0.54 9.5 0.0 2.1 2 1 1 3 3 3 0 CPSF A subunit region IreB PF06135.12 AET41229.1 - 0.11 12.7 0.2 0.33 11.2 0.0 1.9 2 0 0 2 2 2 0 IreB regulatory phosphoprotein DUF5122 PF17164.4 AET41229.1 - 0.12 12.7 0.3 0.82 10.0 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5122) beta-propeller Drc1-Sld2 PF11719.8 AET41230.1 - 1.5e-39 136.9 30.3 1.2e-23 84.4 20.1 2.3 1 1 1 2 2 2 2 DNA replication and checkpoint protein MbeB_N PF04837.12 AET41230.1 - 0.042 14.2 0.4 2.3 8.6 0.0 3.1 3 0 0 3 3 3 0 MbeB-like, N-term conserved region Glyco_transf_34 PF05637.12 AET41231.1 - 0.079 12.7 0.3 0.21 11.3 0.1 1.7 2 0 0 2 2 2 0 galactosyl transferase GMA12/MNN10 family Hap4_Hap_bind PF10297.9 AET41232.1 - 3.1e-08 33.5 8.4 5.9e-08 32.6 8.4 1.5 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 Herpes_BLRF2 PF05812.12 AET41232.1 - 0.2 11.8 0.2 0.2 11.8 0.2 1.9 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein Prothymosin PF03247.14 AET41232.1 - 0.27 11.7 9.0 0.049 14.1 3.4 2.3 2 0 0 2 2 2 0 Prothymosin/parathymosin family bZIP_1 PF00170.21 AET41232.1 - 2.6 8.2 8.1 1.6 8.9 4.6 2.1 2 0 0 2 2 2 0 bZIP transcription factor Cwf_Cwc_15 PF04889.12 AET41232.1 - 4.8 6.8 17.4 0.065 13.0 6.2 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein MMR_HSR1 PF01926.23 AET41233.1 - 1.5e-14 54.1 0.0 3.9e-14 52.7 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AET41233.1 - 4.1e-05 23.6 0.1 0.0018 18.2 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 AET41233.1 - 0.0005 19.6 0.2 0.0023 17.5 0.2 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 AET41233.1 - 0.0067 17.0 0.0 0.017 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 AET41233.1 - 0.0072 16.0 0.2 0.016 14.9 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Septin PF00735.18 AET41233.1 - 0.021 14.1 0.1 0.046 13.0 0.0 1.5 2 0 0 2 2 2 0 Septin MeaB PF03308.16 AET41233.1 - 0.023 13.7 0.0 0.037 13.0 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NTPase_1 PF03266.15 AET41233.1 - 0.026 14.5 0.0 0.044 13.7 0.0 1.4 1 0 0 1 1 1 0 NTPase GTP_EFTU PF00009.27 AET41233.1 - 0.047 13.2 0.0 0.17 11.4 0.0 1.8 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_25 PF13481.6 AET41233.1 - 0.064 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 AET41233.1 - 0.068 13.2 0.0 10 6.2 0.0 2.9 2 1 1 3 3 3 0 Dynamin family ABC_tran PF00005.27 AET41233.1 - 0.091 13.3 0.0 0.23 12.0 0.0 1.6 1 0 0 1 1 1 0 ABC transporter KTI12 PF08433.10 AET41234.1 - 1.5e-95 319.8 0.8 1.6e-95 319.6 0.8 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 AET41234.1 - 1.3e-06 28.6 0.0 9.8e-06 25.8 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 AET41234.1 - 0.00012 22.6 0.1 0.011 16.3 0.0 2.8 1 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 AET41234.1 - 0.0079 16.6 0.1 0.072 13.5 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain ATP_bind_1 PF03029.17 AET41234.1 - 0.0099 15.7 0.0 0.039 13.7 0.0 1.9 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein APS_kinase PF01583.20 AET41234.1 - 0.011 15.7 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase Miff PF05644.11 AET41234.1 - 0.032 13.9 0.5 0.054 13.1 0.5 1.3 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff CPT PF07931.12 AET41234.1 - 0.037 13.9 0.1 0.14 12.0 0.0 1.8 2 1 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_22 PF13401.6 AET41234.1 - 0.05 13.9 0.1 0.45 10.8 0.1 2.7 1 1 1 2 2 2 0 AAA domain Mg_chelatase PF01078.21 AET41234.1 - 0.054 12.9 0.0 0.45 9.9 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA PF00004.29 AET41234.1 - 0.14 12.6 0.0 0.86 10.0 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) mRNA_stabil PF13929.6 AET41235.1 - 4.2e-50 170.4 5.6 6e-50 169.9 5.6 1.2 1 0 0 1 1 1 1 mRNA stabilisation RsfS PF02410.15 AET41235.1 - 1.2e-17 64.2 0.0 2.9e-17 62.9 0.0 1.7 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation XPG_N PF00752.17 AET41236.1 - 2.5e-35 121.0 0.0 4.9e-35 120.0 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 AET41236.1 - 4.6e-28 97.4 0.0 1.1e-27 96.2 0.0 1.7 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 AET41236.1 - 9.8e-07 29.3 1.3 8.3e-06 26.3 0.0 2.5 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 AET41236.1 - 0.003 18.1 0.3 0.011 16.4 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain DUF4910 PF16254.5 AET41236.1 - 0.045 12.6 0.0 0.071 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4910) Transposase_20 PF02371.16 AET41236.1 - 0.12 12.7 0.0 0.32 11.3 0.0 1.7 1 0 0 1 1 1 0 Transposase IS116/IS110/IS902 family AP_endonuc_2 PF01261.24 AET41238.1 - 3.9e-32 111.4 0.0 5.1e-32 111.0 0.0 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Ku_C PF03730.14 AET41238.1 - 0.066 13.9 0.6 0.21 12.3 0.6 1.8 1 0 0 1 1 1 0 Ku70/Ku80 C-terminal arm Pkinase PF00069.25 AET41239.1 - 6.4e-43 147.0 0.2 3.2e-42 144.7 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET41239.1 - 1.9e-22 79.8 0.0 1.2e-21 77.2 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase PAT1 PF09770.9 AET41239.1 - 0.0023 16.3 5.8 0.0033 15.8 5.8 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 APH PF01636.23 AET41239.1 - 0.012 15.6 0.8 0.34 10.8 0.0 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family BORG_CEP PF14957.6 AET41239.1 - 0.13 13.5 4.4 0.38 11.9 4.4 1.7 1 0 0 1 1 1 0 Cdc42 effector PBP_sp32 PF07222.12 AET41239.1 - 3.3 7.1 13.1 5.7 6.3 13.1 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 FlxA PF14282.6 AET41239.1 - 4 7.5 21.9 7.4 6.6 21.9 1.4 1 0 0 1 1 1 0 FlxA-like protein MscS_TM PF12794.7 AET41239.1 - 4.3 6.1 5.1 6.6 5.5 5.1 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Aldose_epim PF01263.20 AET41240.1 - 9.4e-49 166.3 0.3 1.1e-48 166.1 0.3 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase AntA PF08346.12 AET41241.1 - 0.073 13.6 0.1 9.5 6.9 0.0 2.4 2 0 0 2 2 2 0 AntA/AntB antirepressor zf-RING_2 PF13639.6 AET41242.1 - 3.2e-07 30.6 7.5 7.1e-07 29.5 7.5 1.6 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 AET41242.1 - 8.6e-06 25.8 3.5 2.4e-05 24.4 3.5 1.8 1 0 0 1 1 1 1 FANCL C-terminal domain zf-rbx1 PF12678.7 AET41242.1 - 0.0001 22.5 5.8 0.00026 21.2 5.8 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 AET41242.1 - 0.001 19.1 1.6 0.0024 17.9 1.6 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 AET41242.1 - 0.016 15.1 6.6 0.036 13.9 6.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 AET41242.1 - 0.017 15.4 6.3 0.036 14.4 6.3 1.6 1 0 0 1 1 1 0 RING-like domain RINGv PF12906.7 AET41242.1 - 0.042 14.0 4.6 0.085 13.0 4.6 1.6 1 0 0 1 1 1 0 RING-variant domain zf-C3HC4 PF00097.25 AET41242.1 - 0.063 13.2 7.1 0.14 12.1 7.1 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 AET41242.1 - 0.068 12.8 3.4 0.15 11.7 3.4 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 AET41242.1 - 0.52 10.2 5.6 1.7 8.6 5.6 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.6 AET41242.1 - 1.6 8.9 3.4 38 4.5 1.0 2.4 1 1 1 2 2 2 0 Zinc-binding RING-finger PHD PF00628.29 AET41242.1 - 2.2 8.2 4.9 4.1 7.4 4.9 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.6 AET41242.1 - 4.1 7.3 6.5 74 3.3 6.3 2.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 AET41243.1 - 2.4e-26 91.3 1.5 2.2e-14 53.0 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AET41243.1 - 4.2e-05 23.1 0.2 0.0012 18.5 0.1 2.1 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Stb3 PF10330.9 AET41243.1 - 0.18 11.9 0.0 0.57 10.3 0.0 1.8 2 0 0 2 2 2 0 Putative Sin3 binding protein DUF2672 PF10878.8 AET41243.1 - 2.6 8.1 5.5 35 4.5 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2672) SAM_decarbox PF01536.16 AET41244.1 - 3.9e-126 420.9 2.3 4.5e-126 420.6 2.3 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase Recep_L_domain PF01030.24 AET41246.1 - 2.4e-10 40.5 11.8 0.014 15.5 0.1 4.6 1 1 3 4 4 4 4 Receptor L domain LRR_9 PF14580.6 AET41246.1 - 0.0012 18.4 3.0 0.0025 17.3 0.7 2.1 1 1 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 AET41246.1 - 0.0089 16.4 2.5 0.0089 16.4 2.5 5.1 5 2 0 5 5 5 2 Leucine Rich repeats (2 copies) Response_reg PF00072.24 AET41246.1 - 0.066 13.4 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Response regulator receiver domain LRR_5 PF13306.6 AET41246.1 - 0.12 12.4 10.0 0.12 12.3 0.4 2.9 1 1 2 3 3 3 0 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 AET41246.1 - 0.25 11.1 8.0 0.21 11.4 1.4 3.5 3 1 0 3 3 3 0 Leucine rich repeat Bacteriocin_IIc PF10439.9 AET41246.1 - 0.59 10.3 6.3 4.3 7.5 5.1 3.3 2 1 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide GLTP PF08718.11 AET41247.1 - 5e-46 156.7 0.0 1.2e-45 155.5 0.0 1.6 2 0 0 2 2 2 1 Glycolipid transfer protein (GLTP) PCI PF01399.27 AET41248.1 - 7.6e-05 23.2 3.5 0.00012 22.5 0.1 3.0 3 0 0 3 3 3 1 PCI domain DUF2064 PF09837.9 AET41248.1 - 0.12 12.2 0.4 0.37 10.6 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2064) AAA PF00004.29 AET41249.1 - 1.8e-51 174.0 0.0 1.8e-38 132.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_2 PF02933.17 AET41249.1 - 2.9e-12 46.2 1.2 1.5e-11 43.9 0.2 2.6 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_lid_3 PF17862.1 AET41249.1 - 1.5e-10 40.7 0.1 5.7e-10 38.8 0.0 2.0 1 1 1 2 2 2 1 AAA+ lid domain AAA_22 PF13401.6 AET41249.1 - 2.6e-09 37.5 0.2 0.00027 21.2 0.1 3.3 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.6 AET41249.1 - 5.3e-09 36.7 0.3 0.0016 18.8 0.0 2.6 2 1 0 2 2 2 2 AAA ATPase domain TIP49 PF06068.13 AET41249.1 - 2.6e-08 33.5 0.1 0.0017 17.6 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain Mg_chelatase PF01078.21 AET41249.1 - 6.6e-07 28.9 0.1 0.0019 17.6 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 AET41249.1 - 1.3e-06 28.4 0.0 0.0024 17.9 0.0 3.5 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) NACHT PF05729.12 AET41249.1 - 5e-06 26.5 2.1 0.041 13.8 0.0 3.6 4 0 0 4 4 3 1 NACHT domain AAA_33 PF13671.6 AET41249.1 - 6.1e-06 26.5 0.0 0.07 13.3 0.0 2.7 3 0 0 3 3 2 2 AAA domain AAA_2 PF07724.14 AET41249.1 - 6.4e-06 26.4 0.0 0.002 18.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 AET41249.1 - 6.8e-06 25.9 0.4 0.068 12.9 0.1 3.1 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain PhoH PF02562.16 AET41249.1 - 1.4e-05 24.7 0.0 0.015 14.7 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_24 PF13479.6 AET41249.1 - 1.5e-05 24.8 0.2 0.097 12.4 0.0 3.1 2 1 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 AET41249.1 - 4.2e-05 23.3 0.0 0.25 11.1 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein CDC48_N PF02359.18 AET41249.1 - 6.1e-05 23.1 0.0 0.00035 20.7 0.0 2.3 2 1 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain TsaE PF02367.17 AET41249.1 - 8.7e-05 22.5 0.1 0.6 10.1 0.0 2.9 3 0 0 3 3 3 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 AET41249.1 - 8.7e-05 22.9 0.0 0.13 12.7 0.0 2.9 2 0 0 2 2 2 1 RNA helicase Sigma54_activat PF00158.26 AET41249.1 - 9.3e-05 22.2 0.1 0.26 11.0 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain NB-ARC PF00931.22 AET41249.1 - 0.00015 21.0 0.1 0.13 11.5 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain ABC_tran PF00005.27 AET41249.1 - 0.00019 21.9 0.8 0.081 13.4 0.1 2.7 2 0 0 2 2 2 1 ABC transporter AAA_7 PF12775.7 AET41249.1 - 0.00025 20.6 0.1 0.078 12.5 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region ResIII PF04851.15 AET41249.1 - 0.00025 21.1 0.0 0.55 10.2 0.0 2.8 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_30 PF13604.6 AET41249.1 - 0.00025 20.8 0.1 0.82 9.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.9 AET41249.1 - 0.00043 19.6 0.1 0.54 9.4 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.6 AET41249.1 - 0.00081 19.9 0.0 0.48 11.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 AET41249.1 - 0.0016 18.4 0.6 2.6 7.9 0.0 3.7 2 2 0 3 3 3 1 ATPase domain predominantly from Archaea ATPase PF06745.13 AET41249.1 - 0.0036 16.7 0.6 0.3 10.4 0.1 2.9 3 0 0 3 3 3 1 KaiC AAA_19 PF13245.6 AET41249.1 - 0.0038 17.6 0.2 1.2 9.5 0.1 3.0 3 0 0 3 3 2 1 AAA domain AAA_11 PF13086.6 AET41249.1 - 0.0043 16.9 0.0 0.51 10.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain Parvo_NS1 PF01057.17 AET41249.1 - 0.0046 16.1 0.0 3.1 6.8 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Sigma54_activ_2 PF14532.6 AET41249.1 - 0.0047 17.1 0.7 27 4.9 0.1 4.2 2 1 1 3 3 3 0 Sigma-54 interaction domain AAA_23 PF13476.6 AET41249.1 - 0.0048 17.4 1.2 3 8.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain Bac_DnaA PF00308.18 AET41249.1 - 0.0063 16.4 0.0 2 8.2 0.0 2.9 3 0 0 3 3 3 1 Bacterial dnaA protein TniB PF05621.11 AET41249.1 - 0.0071 15.8 0.1 4.4 6.7 0.1 3.1 2 1 0 2 2 2 0 Bacterial TniB protein T2SSE PF00437.20 AET41249.1 - 0.0099 15.0 0.0 1.3 8.0 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein DEAD PF00270.29 AET41249.1 - 0.019 14.8 0.7 11 5.8 0.0 3.9 3 1 0 4 4 4 0 DEAD/DEAH box helicase AAA_25 PF13481.6 AET41249.1 - 0.024 14.2 1.6 4.7 6.7 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_3 PF07726.11 AET41249.1 - 0.025 14.4 0.0 0.25 11.2 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 AET41249.1 - 0.038 14.0 0.1 0.51 10.4 0.0 2.6 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain AAA_29 PF13555.6 AET41249.1 - 0.059 13.1 0.3 4.4 7.1 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_28 PF13521.6 AET41249.1 - 0.06 13.6 0.0 6.2 7.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 AET41249.1 - 0.098 12.6 0.1 28 4.5 0.1 3.0 2 1 0 2 2 2 0 Rad17 P-loop domain Cytidylate_kin PF02224.18 AET41249.1 - 0.12 12.0 0.1 7.8 6.2 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase AAA_17 PF13207.6 AET41249.1 - 0.14 12.5 0.1 31 5.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 AET41249.1 - 0.19 11.5 0.0 1.1 8.9 0.0 2.1 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase TcdB_N PF12918.7 AET41250.1 - 0.022 15.1 0.1 0.067 13.5 0.0 1.8 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain Mt_ATP-synt_B PF05405.14 AET41250.1 - 0.15 11.7 0.3 0.53 9.9 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) PRKCSH PF07915.13 AET41251.1 - 0.0038 18.2 0.1 0.014 16.4 0.1 2.0 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein TIP41 PF04176.13 AET41251.1 - 0.099 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 TIP41-like family UQ_con PF00179.26 AET41252.1 - 2e-52 176.6 0.0 2.2e-52 176.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 AET41252.1 - 0.0011 19.2 0.0 0.0017 18.7 0.0 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 AET41252.1 - 0.005 16.5 0.0 0.0063 16.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 AET41252.1 - 0.019 14.8 0.0 0.029 14.2 0.0 1.3 1 0 0 1 1 1 0 UEV domain CBF PF03914.17 AET41253.1 - 2.4e-48 164.4 2.0 2.4e-48 164.4 2.0 3.2 3 1 0 3 3 3 1 CBF/Mak21 family APC_N_CC PF16689.5 AET41253.1 - 0.0083 16.2 0.2 2.8 8.1 0.0 2.7 2 0 0 2 2 2 2 Coiled-coil N-terminus of APC, dimerisation domain Cnd1 PF12717.7 AET41253.1 - 0.083 12.9 1.6 0.17 11.9 0.3 2.2 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 TEA PF01285.18 AET41255.1 - 1.3e-23 82.8 0.4 1.3e-23 82.8 0.4 2.8 2 0 0 2 2 2 1 TEA/ATTS domain FTHFS PF01268.19 AET41256.1 - 2e-250 831.8 0.9 2.7e-250 831.3 0.9 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 AET41256.1 - 4e-65 218.0 0.2 4e-65 218.0 0.2 2.0 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 AET41256.1 - 7.9e-34 116.4 0.6 2e-33 115.1 0.2 2.0 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain PBP-Tp47_a PF14889.6 AET41256.1 - 0.1 12.3 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 Penicillin-binding protein Tp47 domain a Ribosomal_L19e PF01280.20 AET41257.1 - 2e-59 199.8 10.7 2e-59 199.8 10.7 1.7 2 0 0 2 2 2 1 Ribosomal protein L19e BAF1_ABF1 PF04684.13 AET41258.1 - 1.5 7.8 7.2 0.21 10.6 0.8 2.0 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor CENP-B_dimeris PF09026.10 AET41258.1 - 4.4 7.7 8.6 12 6.4 8.6 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain zinc_ribbon_15 PF17032.5 AET41259.1 - 0.022 15.5 0.9 0.029 15.1 0.9 1.2 1 0 0 1 1 1 0 zinc-ribbon family RecR PF02132.15 AET41259.1 - 0.073 12.7 0.4 0.073 12.7 0.4 1.9 2 0 0 2 2 2 0 RecR protein Fungal_trans PF04082.18 AET41260.1 - 1.3e-12 47.3 2.0 3.3e-12 46.0 2.0 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET41260.1 - 1.5e-09 37.8 11.8 2.9e-09 36.9 11.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sporozoite_P67 PF05642.11 AET41260.1 - 0.048 11.8 3.5 0.067 11.3 3.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4611 PF15387.6 AET41260.1 - 0.13 12.5 2.3 0.32 11.2 2.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Myc_N PF01056.18 AET41260.1 - 0.14 12.0 0.9 0.28 11.0 0.9 1.4 1 0 0 1 1 1 0 Myc amino-terminal region CENP-B_dimeris PF09026.10 AET41260.1 - 1.8 9.0 8.3 3.6 8.0 8.3 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 AET41260.1 - 1.8 6.6 4.2 2.9 5.9 4.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi Mito_carr PF00153.27 AET41261.1 - 1.1e-68 227.3 4.5 1.9e-24 85.4 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Msap1 PF17077.5 AET41262.1 - 2.8e-25 89.2 26.6 1.6e-23 83.4 17.2 3.1 1 1 0 2 2 2 2 Mitotic spindle associated protein SHE1 KH_1 PF00013.29 AET41263.1 - 9.3e-37 124.7 5.9 1.6e-14 53.4 0.0 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 AET41263.1 - 2.3e-08 33.8 1.7 0.059 13.2 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 AET41263.1 - 0.024 14.7 1.2 26 5.0 0.1 3.3 3 0 0 3 3 3 0 NusA-like KH domain KH_4 PF13083.6 AET41263.1 - 0.17 11.7 3.4 3.5 7.6 0.0 3.4 3 1 0 3 3 3 0 KH domain GTP_cyclohydro2 PF00925.20 AET41265.1 - 9.4e-57 191.2 0.0 2e-56 190.1 0.0 1.5 1 1 0 1 1 1 1 GTP cyclohydrolase II CLASP_N PF12348.8 AET41267.1 - 6.2e-71 238.6 11.8 2.1e-70 236.9 1.3 2.9 3 0 0 3 3 3 2 CLASP N terminal Pol_alpha_B_N PF08418.10 AET41268.1 - 8.2e-60 202.8 0.0 1.4e-59 202.1 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 AET41268.1 - 4.2e-46 157.0 0.8 5.8e-46 156.5 0.8 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B PsbU PF06514.11 AET41268.1 - 0.073 13.1 0.0 0.35 10.9 0.0 2.1 2 0 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) Ala_racemase_N PF01168.20 AET41269.1 - 3.2e-20 72.7 0.0 4e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Adaptin_N PF01602.20 AET41270.1 - 3.3e-88 296.5 15.2 4.1e-88 296.2 15.2 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 AET41270.1 - 0.00071 19.7 0.0 0.0022 18.1 0.0 1.9 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Adenine_glyco PF03352.13 AET41270.1 - 0.046 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Methyladenine glycosylase DNA_pol3_delta2 PF13177.6 AET41271.1 - 1.1e-10 41.6 0.1 3e-10 40.1 0.1 1.7 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 AET41271.1 - 7.8e-06 26.3 0.1 2.2e-05 24.9 0.1 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 AET41271.1 - 0.0059 16.4 0.1 0.01 15.6 0.1 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_assoc_2 PF16193.5 AET41271.1 - 0.0071 16.7 0.1 0.035 14.4 0.0 2.1 2 0 0 2 2 2 1 AAA C-terminal domain RuvB_N PF05496.12 AET41271.1 - 0.084 12.6 0.0 0.36 10.6 0.0 2.0 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AET41271.1 - 0.14 12.5 0.0 0.31 11.4 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Ribosomal_L16 PF00252.18 AET41272.1 - 4.2e-37 127.1 0.5 5.4e-37 126.7 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e tRNA-synt_2d PF01409.20 AET41273.1 - 8.4e-45 153.2 0.2 6.2e-25 88.1 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 AET41273.1 - 8.9e-26 90.1 0.0 5.4e-25 87.6 0.0 2.3 2 0 0 2 2 2 1 Ferredoxin-fold anticodon binding domain Phage_connector PF05352.12 AET41273.1 - 0.0089 15.5 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Phage Connector (GP10) FAD_binding_1 PF00667.20 AET41274.1 - 3.7e-29 101.9 0.0 6.7e-29 101.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 AET41274.1 - 1.2e-19 71.0 0.0 2.4e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 AET41274.1 - 7.1e-12 45.9 0.0 1.3e-11 45.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain ATG11 PF10377.9 AET41275.1 - 1.5e-38 131.8 5.1 1.5e-38 131.7 0.0 3.3 3 1 0 3 3 3 1 Autophagy-related protein 11 REV1_C PF16727.5 AET41275.1 - 0.028 14.8 0.4 0.14 12.6 0.0 2.4 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain PX PF00787.24 AET41275.1 - 0.16 11.9 7.0 2.9 7.9 0.1 3.5 3 0 0 3 3 3 0 PX domain CENP-F_leu_zip PF10473.9 AET41275.1 - 2.1 8.3 32.2 0.34 10.9 16.8 4.3 3 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Acetyltransf_1 PF00583.25 AET41276.1 - 5.2e-18 65.4 0.0 6.4e-18 65.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AET41276.1 - 5.2e-12 46.0 0.0 6.9e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AET41276.1 - 7.6e-11 42.0 0.0 1.1e-10 41.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AET41276.1 - 3.4e-08 33.3 0.1 5.6e-08 32.7 0.1 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 AET41276.1 - 0.00014 21.5 0.0 0.00019 21.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 AET41276.1 - 0.00031 20.8 0.0 0.00057 20.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 AET41276.1 - 0.0031 17.6 0.1 0.0054 16.8 0.1 1.5 1 1 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 AET41276.1 - 0.0062 16.0 0.3 0.021 14.3 0.3 2.1 1 1 0 1 1 1 1 Putative acetyl-transferase GNAT_acetyltran PF12746.7 AET41276.1 - 0.0062 16.1 0.0 0.0089 15.6 0.0 1.2 1 0 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_3 PF13302.7 AET41276.1 - 0.011 16.5 0.0 0.013 16.2 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 AET41276.1 - 0.058 13.5 0.2 0.14 12.3 0.1 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PCNA_N PF00705.18 AET41277.1 - 1.1e-49 167.4 2.0 2.3e-49 166.3 1.2 1.8 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 AET41277.1 - 5.4e-49 165.6 0.5 7.3e-48 162.0 0.1 2.1 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 AET41277.1 - 3.1e-07 29.7 0.6 3.8e-06 26.2 0.6 2.0 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 AET41277.1 - 8e-05 22.2 0.1 0.0001 21.9 0.1 1.1 1 0 0 1 1 1 1 Rad9 FOP_dimer PF09398.10 AET41277.1 - 0.055 13.7 0.1 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 FOP N terminal dimerisation domain HMG_box PF00505.19 AET41278.1 - 2.4e-26 91.9 0.9 2.4e-26 91.9 0.9 1.6 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 AET41278.1 - 3e-19 69.4 1.3 3e-19 69.4 1.3 1.4 2 0 0 2 2 2 1 HMG-box domain Ccdc124 PF06244.12 AET41278.1 - 0.00037 21.1 2.2 0.00058 20.4 0.0 1.9 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 CHDNT PF08073.12 AET41278.1 - 0.0093 15.9 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 CHDNT (NUC034) domain YABBY PF04690.13 AET41278.1 - 0.088 13.4 1.4 0.088 13.4 0.6 1.4 1 1 1 2 2 2 0 YABBY protein zf-CCHC PF00098.23 AET41279.1 - 3.5e-06 26.9 16.3 0.00023 21.1 3.1 5.2 5 1 0 5 5 5 3 Zinc knuckle zf-C2H2_10 PF16588.5 AET41279.1 - 0.01 15.5 5.9 0.01 15.5 5.9 5.1 5 1 1 6 6 6 0 C2H2 zinc-finger zf-CCHC_2 PF13696.6 AET41279.1 - 0.015 15.1 7.0 0.015 15.1 7.0 5.4 5 0 0 5 5 5 0 Zinc knuckle tRNA-synt_2b PF00587.25 AET41280.1 - 8e-36 123.7 0.0 1.4e-35 122.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 AET41280.1 - 3.4e-17 62.4 0.7 7.7e-17 61.2 0.7 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 AET41280.1 - 2.3e-13 50.0 0.0 4.4e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 AET41280.1 - 1.6e-10 40.9 0.0 3.3e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 TGS domain DUF1689 PF07954.11 AET41281.1 - 3.4e-53 180.0 2.3 4.5e-53 179.6 2.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1689) Coatomer_E PF04733.14 AET41282.1 - 7.2e-09 35.5 10.4 2.2e-08 33.9 10.4 2.0 1 1 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 AET41282.1 - 0.00016 22.1 4.3 0.12 12.9 0.1 3.5 4 1 1 5 5 5 3 Tetratricopeptide repeat PknG_TPR PF16918.5 AET41282.1 - 0.011 14.5 0.0 0.091 11.5 0.1 2.0 2 0 0 2 2 2 0 Protein kinase G tetratricopeptide repeat GET2 PF08690.10 AET41283.1 - 1.3e-84 284.5 0.6 1.6e-84 284.2 0.6 1.1 1 0 0 1 1 1 1 GET complex subunit GET2 Ribosomal_S15 PF00312.22 AET41284.1 - 1.7e-31 108.2 0.4 1.7e-31 108.2 0.4 2.2 2 0 0 2 2 2 1 Ribosomal protein S15 SAM_DrpA PF18255.1 AET41284.1 - 0.1 12.9 0.1 21 5.4 0.0 3.1 2 0 0 2 2 2 0 DNA processing protein A sterile alpha motif domain Abhydrolase_1 PF00561.20 AET41285.1 - 1.9e-39 135.8 0.0 4.7e-39 134.6 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AET41285.1 - 0.0089 15.3 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 AET41285.1 - 0.016 14.9 0.0 0.024 14.3 0.0 1.2 1 0 0 1 1 1 0 Putative esterase ING PF12998.7 AET41286.1 - 1.4e-20 73.8 3.5 3.1e-20 72.6 3.5 1.6 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 AET41286.1 - 1.1e-06 28.4 8.6 1.9e-06 27.7 8.6 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 AET41286.1 - 0.00083 19.6 1.8 0.0021 18.3 1.8 1.7 1 0 0 1 1 1 1 PHD-like zinc-binding domain Phage_min_cap2 PF06152.11 AET41286.1 - 0.16 10.9 1.7 0.23 10.3 0.6 1.9 2 1 0 2 2 2 0 Phage minor capsid protein 2 zinc_ribbon_10 PF10058.9 AET41286.1 - 0.17 11.6 2.8 0.4 10.4 2.8 1.6 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-C4_Topoisom PF01396.19 AET41286.1 - 0.97 9.3 7.9 4.2 7.2 0.8 2.7 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger DUF4112 PF13430.6 AET41287.1 - 2.2e-30 105.0 1.9 2.8e-30 104.7 1.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) Fcf1 PF04900.12 AET41288.1 - 2.9e-33 114.2 0.2 5e-33 113.5 0.2 1.4 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 AET41288.1 - 8.8e-14 51.8 0.0 1.6e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 PIN like domain Imm-NTF2 PF15655.6 AET41288.1 - 0.031 14.5 0.0 0.069 13.4 0.0 1.5 1 0 0 1 1 1 0 NTF2 fold immunity protein Ribosomal_S4e PF00900.20 AET41289.1 - 2.5e-37 126.6 0.6 1.4e-36 124.2 0.7 2.0 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 AET41289.1 - 3.8e-26 90.5 0.1 6.9e-26 89.6 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 AET41289.1 - 1.1e-19 70.3 6.3 2.4e-19 69.1 6.3 1.6 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 AET41289.1 - 2.5e-08 33.5 0.9 8.5e-08 31.8 0.0 2.1 2 0 0 2 2 2 1 S4 domain KOW PF00467.29 AET41289.1 - 1.1e-05 25.1 1.5 1.1e-05 25.1 1.5 3.4 4 0 0 4 4 4 1 KOW motif dCache_2 PF08269.11 AET41289.1 - 0.048 12.8 0.0 0.23 10.6 0.0 1.9 1 1 1 2 2 2 0 Cache domain Pkinase PF00069.25 AET41290.1 - 4.3e-67 226.3 0.0 7.5e-67 225.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET41290.1 - 1.6e-30 106.3 0.0 2.5e-30 105.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase C2 PF00168.30 AET41290.1 - 9.3e-11 41.9 0.2 1.1e-06 28.9 0.1 2.7 1 1 1 2 2 2 2 C2 domain Pkinase_C PF00433.24 AET41290.1 - 3.5e-10 40.4 2.2 1.4e-09 38.5 2.2 2.2 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 AET41290.1 - 2.8e-09 36.7 0.0 1.4e-08 34.5 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 AET41290.1 - 0.00086 18.4 0.6 0.0051 15.8 0.0 2.2 2 0 0 2 2 2 1 Haspin like kinase domain YrbL-PhoP_reg PF10707.9 AET41290.1 - 0.025 14.1 0.5 0.087 12.3 0.0 2.1 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 AET41290.1 - 0.027 14.1 0.1 0.85 9.2 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 HSF_DNA-bind PF00447.17 AET41291.1 - 6.4e-32 110.0 4.1 1.4e-31 109.0 4.1 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.24 AET41291.1 - 5.6e-29 100.6 0.4 1.4e-28 99.2 0.4 1.7 1 0 0 1 1 1 1 Response regulator receiver domain Ets PF00178.22 AET41291.1 - 0.028 14.9 0.8 0.053 14.0 0.1 1.9 2 0 0 2 2 2 0 Ets-domain 3HCDH_RFF PF18321.1 AET41291.1 - 0.042 14.3 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain VacA2 PF03077.14 AET41291.1 - 0.042 13.7 0.9 0.098 12.5 0.9 1.6 1 0 0 1 1 1 0 Putative vacuolating cytotoxin HALZ PF02183.18 AET41291.1 - 0.067 13.4 2.7 0.16 12.2 2.7 1.7 1 0 0 1 1 1 0 Homeobox associated leucine zipper GIT_CC PF16559.5 AET41291.1 - 0.31 10.9 3.1 0.65 9.9 3.1 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor SET PF00856.28 AET41292.1 - 9e-12 45.7 1.6 2.8e-11 44.1 1.6 1.9 1 1 0 1 1 1 1 SET domain Myticin-prepro PF10690.9 AET41292.1 - 0.34 11.2 12.4 1.8 8.9 3.0 2.7 2 1 0 2 2 2 0 Myticin pre-proprotein from the mussel Cytochrom_C_asm PF01578.20 AET41293.1 - 0.064 13.0 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Cytochrome C assembly protein 5-FTHF_cyc-lig PF01812.20 AET41294.1 - 3.5e-35 121.5 0.0 4.1e-35 121.3 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Aminotran_4 PF01063.19 AET41295.1 - 4.7e-34 118.2 0.0 5.8e-34 117.9 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV TauD PF02668.16 AET41296.1 - 4.3e-56 190.7 2.2 5.3e-56 190.4 2.2 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 AET41297.1 - 3.3e-16 59.2 19.9 5e-16 58.6 19.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sas10_Utp3 PF04000.15 AET41298.1 - 9e-10 39.1 3.9 9e-10 39.1 3.9 1.9 2 1 0 2 2 2 1 Sas10/Utp3/C1D family Cnd1 PF12717.7 AET41298.1 - 0.036 14.1 4.4 0.84 9.7 4.4 2.1 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 VGPC1_C PF16799.5 AET41298.1 - 0.16 12.0 3.7 2.3 8.3 0.3 3.0 2 0 0 2 2 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 Rpp20 PF12328.8 AET41298.1 - 2.6 8.0 8.9 3.5 7.6 6.3 2.3 2 1 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P Thioredoxin_7 PF13899.6 AET41299.1 - 8e-23 80.4 0.2 1.8e-22 79.3 0.2 1.6 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.20 AET41299.1 - 3.5e-14 52.7 0.1 6.9e-14 51.8 0.1 1.5 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 AET41299.1 - 1.2e-11 44.3 0.0 5.2e-11 42.2 0.0 2.0 2 0 0 2 2 2 1 UBA-like domain Thioredox_DsbH PF03190.15 AET41299.1 - 0.055 13.4 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Thioredoxin_2 PF13098.6 AET41299.1 - 0.11 12.9 0.0 0.24 11.9 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain Peptidase_C13 PF01650.18 AET41300.1 - 3.8e-46 157.7 2.9 3.8e-46 157.7 1.7 1.5 2 0 0 2 2 2 1 Peptidase C13 family HTH_38 PF13936.6 AET41300.1 - 0.094 12.5 0.0 0.26 11.1 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HAUS4 PF14735.6 AET41300.1 - 0.33 10.6 2.0 15 5.2 0.2 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 4 Pkinase PF00069.25 AET41301.1 - 1.7e-47 162.0 0.1 2.4e-42 145.1 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AET41301.1 - 1.3e-24 86.9 0.1 1.7e-23 83.2 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 AET41301.1 - 8.8e-07 28.5 0.0 1.5e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 AET41301.1 - 0.011 14.5 0.3 0.037 12.8 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase Kdo PF06293.14 AET41301.1 - 0.093 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ResIII PF04851.15 AET41302.1 - 6.4e-23 81.6 0.0 2e-22 80.0 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AET41302.1 - 1.1e-15 57.8 0.0 2.5e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET41302.1 - 5.3e-12 46.1 0.2 4.5e-11 43.1 0.2 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 AET41302.1 - 0.00022 21.5 0.0 0.00079 19.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 AET41302.1 - 0.012 14.8 0.0 0.027 13.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF1128 PF06569.11 AET41302.1 - 0.032 14.2 0.1 0.091 12.8 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1128) ERCC3_RAD25_C PF16203.5 AET41302.1 - 0.032 13.4 0.0 0.061 12.5 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase SAM35 PF10806.8 AET41303.1 - 4.2e-46 156.3 1.1 8.1e-46 155.4 1.1 1.5 1 0 0 1 1 1 1 SAM35, subunit of SAM coomplex STE PF02200.16 AET41304.1 - 6.1e-60 200.4 1.3 1e-59 199.7 1.3 1.4 1 0 0 1 1 1 1 STE like transcription factor Tcf25 PF04910.14 AET41305.1 - 1.1e-76 258.2 2.9 1.5e-76 257.7 2.9 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 TPR_2 PF07719.17 AET41305.1 - 0.065 13.4 4.5 0.1 12.8 0.6 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 AET41305.1 - 0.13 12.5 0.0 1 9.8 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat IFRD PF05004.13 AET41305.1 - 0.16 11.0 3.8 1.2 8.2 1.6 2.3 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) TPR_1 PF00515.28 AET41305.1 - 2.1 8.3 5.4 0.45 10.4 0.6 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Ipi1_N PF12333.8 AET41306.1 - 1.3e-24 86.7 0.1 2.6e-24 85.7 0.1 1.5 1 0 0 1 1 1 1 Rix1 complex component involved in 60S ribosome maturation Dopey_N PF04118.14 AET41306.1 - 0.036 13.2 0.1 0.057 12.5 0.1 1.3 1 0 0 1 1 1 0 Dopey, N-terminal RRM_1 PF00076.22 AET41307.1 - 3e-44 148.7 0.0 1.3e-17 63.4 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AET41307.1 - 0.00022 21.3 0.1 0.033 14.3 0.0 3.6 3 1 0 3 3 3 1 RNA recognition motif RRM_3 PF08777.11 AET41307.1 - 0.0038 17.3 0.0 0.0089 16.1 0.0 1.7 1 1 0 1 1 1 1 RNA binding motif RRM_occluded PF16842.5 AET41307.1 - 0.013 15.4 0.0 0.31 10.9 0.0 2.4 2 0 0 2 2 2 0 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 AET41307.1 - 0.015 15.3 0.0 0.039 14.0 0.0 1.8 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif API5 PF05918.11 AET41307.1 - 0.074 11.8 8.9 0.11 11.3 8.9 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Tubulin_3 PF14881.6 AET41307.1 - 3.3 7.4 4.9 6.9 6.3 0.0 2.4 2 0 0 2 2 2 0 Tubulin domain SelP_N PF04592.14 AET41307.1 - 3.7 6.9 13.2 6.1 6.2 13.2 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region zf-C2H2 PF00096.26 AET41308.1 - 2.4e-07 30.8 15.1 0.00015 22.0 2.7 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AET41308.1 - 3.4e-05 24.3 12.1 0.0085 16.9 1.8 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AET41308.1 - 0.00056 20.2 3.9 0.00056 20.2 3.9 2.8 3 0 0 3 3 3 1 Zinc-finger double domain zf-met PF12874.7 AET41308.1 - 0.0022 18.3 2.4 0.17 12.4 0.4 3.0 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AET41308.1 - 0.041 14.2 2.7 0.47 10.8 0.2 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding RhoGEF PF00621.20 AET41309.1 - 1.1e-12 48.6 0.1 2.1e-12 47.7 0.1 1.5 1 0 0 1 1 1 1 RhoGEF domain ABC2_membrane PF01061.24 AET41310.1 - 1.7e-82 275.9 53.0 1.5e-42 145.4 25.0 3.0 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.12 AET41310.1 - 2.8e-36 123.3 0.3 1.7e-30 104.7 0.0 3.5 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.27 AET41310.1 - 2.6e-35 121.9 0.0 2.6e-16 60.4 0.0 3.7 4 0 0 4 4 3 2 ABC transporter ABC_trans_N PF14510.6 AET41310.1 - 4.3e-18 65.7 0.0 2e-17 63.5 0.0 2.2 2 0 0 2 2 2 1 ABC-transporter N-terminal AAA_25 PF13481.6 AET41310.1 - 2.3e-07 30.6 0.6 3.5e-06 26.7 0.1 2.5 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 AET41310.1 - 1.8e-06 28.5 0.1 0.00032 21.1 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 AET41310.1 - 6.2e-05 23.0 0.1 0.0024 17.8 0.0 2.7 3 0 0 3 3 3 1 RsgA GTPase AAA_29 PF13555.6 AET41310.1 - 0.00019 21.1 1.9 0.0063 16.2 0.3 3.2 3 0 0 3 3 3 1 P-loop containing region of AAA domain ABC2_membrane_3 PF12698.7 AET41310.1 - 0.00022 20.5 42.2 0.004 16.3 11.2 3.9 3 1 0 3 3 3 2 ABC-2 family transporter protein AAA_21 PF13304.6 AET41310.1 - 0.00026 20.9 0.1 0.094 12.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 AET41310.1 - 0.00052 20.0 0.2 0.51 10.2 0.0 2.7 2 0 0 2 2 2 2 NACHT domain AAA_18 PF13238.6 AET41310.1 - 0.00063 20.3 0.2 0.2 12.2 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_33 PF13671.6 AET41310.1 - 0.003 17.7 0.2 1.3 9.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 AET41310.1 - 0.0094 16.5 2.9 0.013 16.0 0.0 2.7 4 0 0 4 4 2 1 AAA domain SMC_N PF02463.19 AET41310.1 - 0.0098 15.4 0.0 1.7 8.1 0.0 3.1 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 AET41310.1 - 0.012 15.9 0.7 0.39 11.0 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 AET41310.1 - 0.031 14.6 3.0 0.76 10.0 0.2 3.0 3 0 0 3 3 2 0 AAA domain AAA_30 PF13604.6 AET41310.1 - 0.069 12.9 1.3 8.2 6.1 0.7 2.5 2 0 0 2 2 2 0 AAA domain Phage_holin_1 PF04531.13 AET41310.1 - 0.13 12.8 0.6 0.74 10.4 0.6 2.3 1 0 0 1 1 1 0 Bacteriophage holin cobW PF02492.19 AET41310.1 - 0.27 10.8 4.4 9.2 5.8 0.8 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Brix PF04427.18 AET41311.1 - 5.1e-26 92.0 0.7 9.3e-26 91.1 0.7 1.4 1 0 0 1 1 1 1 Brix domain Xpo1 PF08389.12 AET41312.1 - 0.048 13.7 2.0 7.5 6.6 0.5 3.4 2 0 0 2 2 2 0 Exportin 1-like protein MMR_HSR1 PF01926.23 AET41313.1 - 6.8e-17 61.6 0.0 1.3e-16 60.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AET41313.1 - 8.3e-06 25.8 0.0 0.002 18.1 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 AET41313.1 - 2e-05 24.2 0.0 3.5e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 AET41313.1 - 3.4e-05 23.3 0.1 9.6e-05 21.9 0.0 1.8 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 AET41313.1 - 6.7e-05 23.0 0.2 0.13 12.3 0.0 2.7 2 1 1 3 3 3 2 Dynamin family GTP_EFTU PF00009.27 AET41313.1 - 0.00016 21.3 0.0 0.0017 17.9 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Ploopntkinase3 PF18751.1 AET41313.1 - 0.046 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_29 PF13555.6 AET41313.1 - 0.13 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Gar1 PF04410.14 AET41314.1 - 8e-41 139.4 0.0 9.5e-41 139.1 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region DHO_dh PF01180.21 AET41315.1 - 6.6e-97 324.3 0.1 7.8e-97 324.0 0.1 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 AET41315.1 - 9.7e-06 24.8 0.1 0.015 14.4 0.1 2.8 2 1 0 2 2 2 2 FMN-dependent dehydrogenase BING4CT PF08149.11 AET41316.1 - 3.7e-37 126.0 0.0 2.3e-34 117.0 0.0 3.4 3 0 0 3 3 3 1 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 AET41316.1 - 3.7e-07 30.4 0.0 4.2 7.7 0.0 4.6 2 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AET41316.1 - 5.1e-06 27.1 0.2 0.0071 17.2 0.0 4.7 5 1 0 5 5 5 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 AET41316.1 - 0.0073 15.4 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 Coatomer WD associated region PQQ_2 PF13360.6 AET41316.1 - 0.043 13.4 0.0 0.21 11.1 0.0 1.8 1 1 1 2 2 2 0 PQQ-like domain RPN2_C PF18004.1 AET41317.1 - 9.3e-52 175.2 8.0 9.3e-52 175.2 8.0 1.8 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 AET41317.1 - 7.8e-41 136.5 23.2 1.1e-06 28.7 1.5 9.1 9 0 0 9 9 9 7 Proteasome/cyclosome repeat HEAT_2 PF13646.6 AET41317.1 - 1.5e-21 76.6 1.8 1.4e-14 54.2 0.0 4.9 4 1 1 5 5 5 3 HEAT repeats HEAT PF02985.22 AET41317.1 - 6e-08 32.3 0.3 0.79 10.2 0.0 5.6 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 AET41317.1 - 0.0021 18.5 3.7 0.57 10.8 0.0 4.3 3 1 1 4 4 3 1 HEAT-like repeat RICTOR_V PF14668.6 AET41317.1 - 0.047 13.9 0.2 1.2 9.5 0.0 3.3 2 1 1 3 3 2 0 Rapamycin-insensitive companion of mTOR, domain 5 Arm PF00514.23 AET41317.1 - 0.077 13.1 0.3 42 4.4 0.0 3.6 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat PBP_sp32 PF07222.12 AET41317.1 - 0.11 11.9 1.2 0.19 11.2 1.2 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 TPR_2 PF07719.17 AET41317.1 - 0.21 11.8 2.4 1 9.6 1.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 AET41317.1 - 1.9 8.9 6.1 1.1 9.7 1.4 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat HEAT_PBS PF03130.16 AET41317.1 - 3.2 8.7 4.9 48 5.0 0.0 4.1 5 0 0 5 5 4 0 PBS lyase HEAT-like repeat 2-Hacid_dh_C PF02826.19 AET41318.1 - 2.3e-53 180.2 0.0 3.7e-53 179.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 AET41318.1 - 6.4e-38 129.5 0.0 8.2e-38 129.1 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ACT PF01842.25 AET41318.1 - 5.5e-05 22.9 0.0 0.00022 20.9 0.0 2.0 2 0 0 2 2 2 1 ACT domain NAD_binding_2 PF03446.15 AET41318.1 - 0.0005 20.3 1.0 0.0011 19.1 0.2 2.0 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 AET41318.1 - 0.0066 16.5 0.1 0.015 15.3 0.1 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Rossmann-like PF10727.9 AET41318.1 - 0.071 13.0 0.3 0.26 11.2 0.4 2.0 1 1 0 1 1 1 0 Rossmann-like domain XdhC_C PF13478.6 AET41318.1 - 0.15 12.6 0.0 0.39 11.2 0.0 1.7 2 0 0 2 2 2 0 XdhC Rossmann domain SPO22 PF08631.10 AET41319.1 - 5.8e-60 203.1 23.0 6.4e-57 193.1 2.6 4.5 4 1 0 4 4 4 3 Meiosis protein SPO22/ZIP4 like TPR_2 PF07719.17 AET41319.1 - 0.017 15.2 0.4 11 6.4 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat Med25 PF11232.8 AET41319.1 - 0.074 13.0 0.8 0.98 9.4 0.1 2.7 2 0 0 2 2 2 0 Mediator complex subunit 25 PTOV activation and synapsin 2 TPR_1 PF00515.28 AET41319.1 - 0.34 10.8 2.0 42 4.2 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat PPR PF01535.20 AET41319.1 - 0.34 11.2 1.6 22 5.6 0.2 4.1 4 0 0 4 4 4 0 PPR repeat APH PF01636.23 AET41320.1 - 3.2e-10 40.3 0.0 1.8e-09 37.9 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 AET41320.1 - 0.0028 17.0 0.0 0.28 10.5 0.0 2.7 3 0 0 3 3 3 2 Lipopolysaccharide kinase (Kdo/WaaP) family HORMA PF02301.18 AET41322.1 - 4.2e-61 206.2 0.1 8.4e-61 205.2 0.1 1.5 1 0 0 1 1 1 1 HORMA domain PHD_2 PF13831.6 AET41322.1 - 0.27 10.8 4.8 0.69 9.5 4.8 1.7 1 0 0 1 1 1 0 PHD-finger Peptidase_M24 PF00557.24 AET41323.1 - 1.5e-53 181.6 0.0 2.2e-53 181.1 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 AET41323.1 - 6.9e-38 129.1 0.0 1.5e-37 128.0 0.0 1.6 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain NAD_binding_8 PF13450.6 AET41323.1 - 0.032 14.5 0.0 0.11 12.8 0.0 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain RasGAP_C PF03836.15 AET41324.1 - 0.079 13.1 1.9 0.13 12.4 1.9 1.3 1 0 0 1 1 1 0 RasGAP C-terminus Tnp_22_dsRBD PF17490.2 AET41324.1 - 0.12 12.4 0.0 0.4 10.7 0.0 1.9 1 0 0 1 1 1 0 L1 transposable element dsRBD-like domain PPR_2 PF13041.6 AET41325.1 - 4.9e-11 42.6 5.0 3.4e-09 36.8 0.1 4.4 4 1 1 5 5 5 1 PPR repeat family Sec8_exocyst PF04048.14 AET41325.1 - 0.045 13.6 2.6 0.16 11.8 2.6 2.0 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain PPR_1 PF12854.7 AET41325.1 - 2.2 8.1 4.4 15 5.4 0.0 3.5 4 0 0 4 4 4 0 PPR repeat MAM33 PF02330.16 AET41326.1 - 3.1e-57 194.0 3.5 3.5e-57 193.8 3.5 1.0 1 0 0 1 1 1 1 Mitochondrial glycoprotein Cons_hypoth95 PF03602.15 AET41326.1 - 0.02 14.6 0.0 0.047 13.3 0.0 1.7 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Pmp3 PF01679.17 AET41327.1 - 1.1e-18 67.2 6.3 1.4e-18 66.8 6.3 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator UPF0029 PF01205.19 AET41329.1 - 2.6e-30 104.9 0.0 3.6e-30 104.4 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 VitD-bind_III PF09164.10 AET41329.1 - 0.071 13.1 0.2 0.35 10.9 0.1 2.0 1 1 1 2 2 2 0 Vitamin D binding protein, domain III FAD-oxidase_C PF02913.19 AET41330.1 - 4.6e-61 206.6 0.0 6.3e-61 206.2 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 AET41330.1 - 1e-35 122.5 0.1 1.8e-35 121.7 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain AA_permease PF00324.21 AET41331.1 - 1.3e-123 413.2 33.7 1.6e-123 412.9 33.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AET41331.1 - 7.2e-32 110.7 33.4 8.9e-32 110.5 33.4 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3367 PF11847.8 AET41331.1 - 0.042 11.7 0.3 0.067 11.1 0.3 1.2 1 0 0 1 1 1 0 Alpha-(1->3)-arabinofuranosyltransferase HIT PF01230.23 AET41332.1 - 2.8e-24 85.7 0.2 3.8e-24 85.3 0.2 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 AET41332.1 - 9e-11 42.3 0.4 1.7e-10 41.4 0.4 1.5 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 AET41332.1 - 0.1 12.5 1.5 0.25 11.2 1.5 1.7 1 1 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 AAA PF00004.29 AET41333.1 - 3.1e-98 325.3 0.0 2.8e-48 163.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AET41333.1 - 1.7e-25 88.5 5.4 2.5e-13 49.6 0.4 2.8 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 AET41333.1 - 3.1e-16 59.3 1.4 5.6e-16 58.5 0.6 2.0 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 AET41333.1 - 8.2e-14 51.6 0.0 1.3e-05 25.0 0.0 2.9 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 AET41333.1 - 1.9e-13 50.9 0.2 5.6e-07 29.8 0.0 2.9 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 AET41333.1 - 3.5e-13 50.3 0.3 0.00012 22.5 0.0 5.0 3 2 0 3 3 3 2 AAA ATPase domain AAA_33 PF13671.6 AET41333.1 - 2.5e-11 43.9 0.0 1.3e-05 25.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 AET41333.1 - 3e-11 43.5 1.7 1e-05 25.6 0.1 3.9 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) CDC48_2 PF02933.17 AET41333.1 - 2.4e-10 40.0 0.1 1e-09 38.0 0.1 2.1 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 TIP49 PF06068.13 AET41333.1 - 2.6e-09 36.7 0.0 0.0018 17.5 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 AET41333.1 - 1.1e-08 35.5 0.9 0.072 13.4 0.0 4.0 2 2 2 4 4 4 2 AAA domain Vps4_C PF09336.10 AET41333.1 - 2.2e-07 30.8 1.4 2.6e-05 24.1 0.1 3.0 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain RNA_helicase PF00910.22 AET41333.1 - 2.7e-07 30.9 0.0 0.012 16.0 0.0 3.0 3 0 0 3 3 2 2 RNA helicase AAA_14 PF13173.6 AET41333.1 - 3.4e-07 30.4 0.0 0.021 14.9 0.0 3.0 3 0 0 3 3 3 2 AAA domain Mg_chelatase PF01078.21 AET41333.1 - 4.1e-07 29.6 0.4 0.032 13.6 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 AET41333.1 - 7.9e-07 29.0 0.0 0.03 14.0 0.0 2.8 2 0 0 2 2 2 2 IstB-like ATP binding protein ATPase PF06745.13 AET41333.1 - 2.1e-06 27.3 1.0 0.35 10.2 0.0 3.7 2 1 0 3 3 3 2 KaiC AAA_7 PF12775.7 AET41333.1 - 4.7e-06 26.2 0.1 0.059 12.9 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 AET41333.1 - 4.8e-06 26.4 0.1 0.079 12.7 0.0 3.1 3 1 0 3 3 2 2 AAA domain AAA_18 PF13238.6 AET41333.1 - 6.4e-06 26.7 0.0 0.22 12.1 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 AET41333.1 - 7.9e-06 25.6 4.2 0.04 13.5 0.2 4.2 2 2 0 3 3 3 1 AAA domain ABC_tran PF00005.27 AET41333.1 - 1.3e-05 25.7 0.1 0.027 15.0 0.0 3.7 3 1 0 3 3 2 1 ABC transporter Sigma54_activat PF00158.26 AET41333.1 - 1.6e-05 24.7 0.1 0.18 11.5 0.0 3.4 3 1 0 3 3 2 2 Sigma-54 interaction domain PhoH PF02562.16 AET41333.1 - 2.7e-05 23.7 0.2 0.17 11.4 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein Parvo_NS1 PF01057.17 AET41333.1 - 3.8e-05 22.9 0.1 0.13 11.3 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_28 PF13521.6 AET41333.1 - 4.5e-05 23.8 0.2 0.57 10.4 0.0 3.0 3 0 0 3 3 2 2 AAA domain Bac_DnaA PF00308.18 AET41333.1 - 5.5e-05 23.1 0.0 0.12 12.2 0.0 3.0 3 0 0 3 3 3 1 Bacterial dnaA protein AAA_11 PF13086.6 AET41333.1 - 5.5e-05 23.1 0.6 0.74 9.6 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_3 PF07726.11 AET41333.1 - 0.00017 21.5 0.0 0.8 9.6 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 AET41333.1 - 0.00017 20.8 0.0 0.22 10.6 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF815) TsaE PF02367.17 AET41333.1 - 0.00031 20.7 0.0 0.7 9.9 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ResIII PF04851.15 AET41333.1 - 0.00047 20.2 0.0 0.095 12.7 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 AET41333.1 - 0.00069 18.9 0.0 1.1 8.5 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_17 PF13207.6 AET41333.1 - 0.0013 19.2 4.1 0.57 10.6 0.0 3.5 5 0 0 5 5 2 2 AAA domain NACHT PF05729.12 AET41333.1 - 0.0019 18.2 0.2 2.2 8.1 0.0 3.3 3 0 0 3 3 3 1 NACHT domain AAA_19 PF13245.6 AET41333.1 - 0.0021 18.4 0.6 2.9 8.2 0.0 3.1 2 1 1 3 3 2 1 AAA domain AAA_30 PF13604.6 AET41333.1 - 0.0023 17.7 0.7 2.7 7.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 AET41333.1 - 0.0048 16.8 2.3 6 6.7 0.0 3.8 3 1 1 4 4 3 0 ATPase domain predominantly from Archaea Zeta_toxin PF06414.12 AET41333.1 - 0.0076 15.6 0.1 2 7.6 0.1 2.7 2 0 0 2 2 2 1 Zeta toxin Sigma54_activ_2 PF14532.6 AET41333.1 - 0.013 15.6 0.0 1.4 9.0 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain IPT PF01745.16 AET41333.1 - 0.018 14.5 0.1 2.2 7.6 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase NB-ARC PF00931.22 AET41333.1 - 0.024 13.8 0.1 5 6.2 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain Zot PF05707.12 AET41333.1 - 0.036 13.7 0.0 2.8 7.5 0.0 3.3 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) KAP_NTPase PF07693.14 AET41333.1 - 0.04 13.2 0.2 1.9 7.6 0.0 2.8 2 2 0 2 2 2 0 KAP family P-loop domain NTPase_1 PF03266.15 AET41333.1 - 0.069 13.1 1.3 8.3 6.3 0.0 3.7 4 0 0 4 4 3 0 NTPase AAA_6 PF12774.7 AET41333.1 - 0.12 11.4 0.4 5.6 5.8 0.0 2.5 3 0 0 3 3 2 0 Hydrolytic ATP binding site of dynein motor region Cyclin_N PF00134.23 AET41334.1 - 8.1e-17 61.2 0.1 1.4e-16 60.4 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 AET41334.1 - 5.8e-06 26.8 1.0 1.4e-05 25.6 0.0 1.9 2 0 0 2 2 2 1 Cyclin Na_Ca_ex PF01699.24 AET41335.1 - 4.8e-46 156.4 41.2 4.6e-24 85.1 13.4 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Ribosomal_60s PF00428.19 AET41338.1 - 3.1e-22 79.0 10.4 4.1e-22 78.6 10.4 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein IATP PF04568.12 AET41339.1 - 4.9e-13 49.3 0.2 6.5e-13 48.9 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP Fib_alpha PF08702.10 AET41339.1 - 0.025 14.8 1.7 0.029 14.6 1.7 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF16 PF01519.16 AET41339.1 - 0.03 14.8 2.3 0.037 14.5 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF16 CorA PF01544.18 AET41339.1 - 0.063 12.6 2.1 0.073 12.4 2.1 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein XhlA PF10779.9 AET41339.1 - 0.069 13.4 2.7 0.088 13.0 2.7 1.2 1 0 0 1 1 1 0 Haemolysin XhlA WD40 PF00400.32 AET41340.1 - 1.4e-08 35.2 13.4 0.19 12.6 0.3 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET41340.1 - 2.9e-05 24.3 0.2 0.36 11.2 0.0 3.9 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 AET41340.1 - 0.031 13.2 0.4 0.058 12.3 0.2 1.5 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain PQQ PF01011.21 AET41340.1 - 0.043 13.7 0.1 0.24 11.4 0.0 2.3 2 0 0 2 2 2 0 PQQ enzyme repeat SUN PF03856.13 AET41340.1 - 0.058 12.8 0.5 0.1 12.1 0.5 1.4 1 0 0 1 1 1 0 Beta-glucosidase (SUN family) HMGL-like PF00682.19 AET41341.1 - 1e-84 284.2 0.2 1.8e-84 283.4 0.2 1.4 1 0 0 1 1 1 1 HMGL-like Trp_syntA PF00290.20 AET41341.1 - 0.089 11.6 0.0 8.3 5.2 0.0 2.4 2 0 0 2 2 2 0 Tryptophan synthase alpha chain FliG_N PF14842.6 AET41341.1 - 0.11 13.1 0.0 0.23 12.0 0.0 1.5 1 0 0 1 1 1 0 FliG N-terminal domain Cullin PF00888.22 AET41342.1 - 1.4e-145 486.4 16.5 1.7e-145 486.1 16.5 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 AET41342.1 - 2.1e-23 82.1 2.1 4.3e-23 81.1 0.6 2.5 2 0 0 2 2 2 1 Cullin protein neddylation domain ANAPC4 PF12896.7 AET41342.1 - 0.026 14.0 1.0 0.21 11.0 1.1 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 MARVEL PF01284.23 AET41343.1 - 0.00076 19.5 2.5 0.0012 18.9 2.5 1.3 1 0 0 1 1 1 1 Membrane-associating domain Vma12 PF11712.8 AET41343.1 - 0.11 12.5 0.0 0.28 11.3 0.0 1.7 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase T4SS_CagC PF16943.5 AET41343.1 - 0.15 12.2 0.2 0.15 12.2 0.2 1.7 2 0 0 2 2 2 0 Cag pathogenicity island, type IV secretory system DUF4131 PF13567.6 AET41343.1 - 0.95 9.1 4.3 3.2 7.4 0.1 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) SHP PF03579.13 AET41343.1 - 2.6 8.1 4.9 5.1 7.1 0.0 3.0 3 0 0 3 3 3 0 Small hydrophobic protein DUF4271 PF14093.6 AET41343.1 - 3.2 7.6 8.4 1.1 9.1 3.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4271) Mit_KHE1 PF10173.9 AET41344.1 - 9e-55 185.7 0.8 1.2e-54 185.3 0.8 1.2 1 0 0 1 1 1 1 Mitochondrial K+-H+ exchange-related Colicin_K PF17500.2 AET41344.1 - 0.021 15.4 0.1 0.049 14.2 0.1 1.6 1 0 0 1 1 1 0 Colicin-K Etmic-2 PF06670.11 AET41344.1 - 0.1 11.5 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 Microneme protein Etmic-2 Ribosomal_L41 PF05162.13 AET41345.1 - 1.3e-11 44.4 25.6 1.3e-11 44.3 25.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L41 ATP-synt_ab PF00006.25 AET41346.1 - 3.3e-113 376.6 0.1 6.4e-113 375.6 0.1 1.6 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain Hom_end_hint PF05203.16 AET41346.1 - 1.9e-74 250.5 0.0 3.2e-74 249.7 0.0 1.4 1 0 0 1 1 1 1 Hom_end-associated Hint ATP-synt_ab_Xtn PF16886.5 AET41346.1 - 3.8e-44 149.4 0.0 8e-44 148.4 0.0 1.6 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 AET41346.1 - 1.3e-15 57.6 2.5 3.3e-15 56.3 2.5 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Hom_end PF05204.14 AET41346.1 - 8.9e-15 54.8 0.2 1e-12 48.2 0.1 3.2 2 1 0 2 2 2 1 Homing endonuclease Hint PF01079.20 AET41346.1 - 0.0015 18.1 0.0 0.0037 16.8 0.0 1.6 1 0 0 1 1 1 1 Hint module Cas_St_Csn2 PF16813.5 AET41346.1 - 0.11 11.5 0.1 0.24 10.5 0.1 1.5 1 0 0 1 1 1 0 CRISPR-associated protein Csn2 subfamily St Metallophos PF00149.28 AET41348.1 - 1.2e-33 117.4 0.4 2.1e-33 116.6 0.4 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Rho_GDI PF02115.17 AET41349.1 - 3e-60 203.3 1.2 3.5e-60 203.1 1.2 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor R3H PF01424.22 AET41350.1 - 3.5e-11 42.9 0.0 3.5e-11 42.9 0.0 1.9 2 0 0 2 2 2 1 R3H domain DUF3413 PF11893.8 AET41350.1 - 7.3 5.7 5.3 12 5.0 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) Ufd2P_core PF10408.9 AET41351.1 - 4.4e-201 669.8 10.2 5.6e-201 669.4 10.2 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 AET41351.1 - 7.4e-27 93.3 1.3 2e-26 91.9 1.3 1.8 1 0 0 1 1 1 1 U-box domain Ribosomal_L29 PF00831.23 AET41352.1 - 1.7e-16 59.9 11.2 2.7e-16 59.3 4.1 2.2 2 0 0 2 2 2 2 Ribosomal L29 protein PilJ PF13675.6 AET41352.1 - 0.017 15.1 4.5 0.043 13.8 0.9 2.0 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Annexin PF00191.20 AET41352.1 - 0.049 13.7 0.2 0.11 12.6 0.0 1.7 2 0 0 2 2 2 0 Annexin Phage_sheath_1C PF17482.2 AET41352.1 - 0.062 13.3 0.4 0.096 12.7 0.4 1.3 1 0 0 1 1 1 0 Phage tail sheath C-terminal domain MRP-L47 PF06984.13 AET41352.1 - 0.16 12.1 3.3 0.21 11.7 1.1 2.3 1 1 1 2 2 2 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) FlxA PF14282.6 AET41352.1 - 2.8 8.0 9.6 0.23 11.5 4.2 1.8 1 1 1 2 2 2 0 FlxA-like protein Arf PF00025.21 AET41353.1 - 1.9e-79 265.1 0.0 2.2e-79 264.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 AET41353.1 - 5.9e-15 55.2 0.0 7.3e-15 54.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 AET41353.1 - 2.4e-14 53.6 0.0 3.2e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 AET41353.1 - 9.3e-14 51.3 0.0 1e-13 51.2 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 AET41353.1 - 1.6e-13 50.5 1.0 9.3e-10 38.2 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 AET41353.1 - 6.5e-11 42.0 0.0 8.1e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AET41353.1 - 1.1e-05 25.5 0.0 1.7e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRP54 PF00448.22 AET41353.1 - 0.0078 15.9 0.5 0.015 14.9 0.2 1.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 AET41353.1 - 0.014 15.3 0.1 2.4 8.1 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 AET41353.1 - 0.026 14.1 0.4 6.4 6.3 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 AET41353.1 - 0.042 14.0 0.3 0.066 13.4 0.3 1.6 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 AET41353.1 - 0.05 12.9 1.3 0.37 10.1 1.3 2.0 1 1 0 1 1 1 0 6-phosphofructo-2-kinase NACHT PF05729.12 AET41353.1 - 0.11 12.4 0.6 9.6 6.1 0.0 2.1 2 0 0 2 2 2 0 NACHT domain Thymidylate_kin PF02223.17 AET41353.1 - 0.13 11.9 1.0 0.97 9.1 0.3 2.0 2 0 0 2 2 2 0 Thymidylate kinase ABC_tran PF00005.27 AET41353.1 - 0.14 12.7 0.1 0.31 11.6 0.1 1.7 1 1 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 AET41353.1 - 0.15 12.6 0.1 0.22 12.1 0.1 1.4 1 1 0 1 1 1 0 AAA domain Arf PF00025.21 AET41354.1 - 3.5e-36 124.3 0.0 4e-36 124.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 AET41354.1 - 3e-07 30.0 0.0 5.9e-07 29.1 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 AET41354.1 - 0.0005 20.3 0.0 0.0015 18.8 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 AET41354.1 - 0.0048 16.5 0.0 0.039 13.5 0.0 2.0 1 1 0 1 1 1 1 Ras family G-alpha PF00503.20 AET41354.1 - 0.0054 15.9 0.3 0.014 14.6 0.1 1.6 2 0 0 2 2 2 1 G-protein alpha subunit cobW PF02492.19 AET41354.1 - 0.043 13.4 0.2 4.8 6.7 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 AET41354.1 - 0.046 13.2 0.1 1 8.8 0.0 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 AET41354.1 - 0.23 10.8 0.1 1.4 8.2 0.1 1.9 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF5099 PF17025.5 AET41355.1 - 0.024 15.1 0.0 0.043 14.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5099) CD52 PF15116.6 AET41355.1 - 0.15 12.1 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 CAMPATH-1 antigen Sugar_tr PF00083.24 AET41356.1 - 7.1e-118 394.3 26.6 8.7e-118 394.0 26.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AET41356.1 - 2.6e-13 49.6 39.6 8.2e-11 41.4 9.7 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily Sec31 PF11549.8 AET41357.1 - 2.4e-21 75.4 0.7 8.3e-21 73.6 0.7 2.0 1 0 0 1 1 1 1 Protein transport protein SEC31 ANAPC4_WD40 PF12894.7 AET41357.1 - 2.5e-09 37.3 0.8 0.0052 17.0 0.0 4.2 3 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Sec16_C PF12931.7 AET41357.1 - 3.2e-08 33.6 1.5 9.9e-08 32.0 1.5 1.8 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 SRA1 PF07304.11 AET41357.1 - 1e-07 31.8 0.0 1e-07 31.8 0.0 3.5 2 1 1 3 3 3 1 Steroid receptor RNA activator (SRA1) WD40 PF00400.32 AET41357.1 - 1.5e-07 32.0 5.7 0.0055 17.5 0.2 6.0 5 0 0 5 5 5 2 WD domain, G-beta repeat Prp18 PF02840.15 AET41357.1 - 0.0039 17.3 0.8 0.019 15.0 0.0 2.4 2 1 0 2 2 2 1 Prp18 domain BBS2_Mid PF14783.6 AET41357.1 - 0.059 13.4 0.5 0.18 11.8 0.1 2.1 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Scm3 PF10384.9 AET41359.1 - 2.5e-22 78.3 2.6 7.1e-22 76.9 1.5 2.1 2 0 0 2 2 2 1 Centromere protein Scm3 Pro_isomerase PF00160.21 AET41360.1 - 1.1e-46 159.0 0.3 4e-46 157.2 0.1 1.8 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 AET41360.1 - 2.4e-06 27.2 1.3 0.00058 19.8 1.2 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 AET41360.1 - 1.5e-05 24.6 1.5 3.5e-05 23.4 0.6 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 AET41360.1 - 0.015 15.5 0.4 0.045 14.0 0.4 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_9 PF13371.6 AET41360.1 - 0.019 15.1 0.3 0.038 14.1 0.3 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 AET41360.1 - 0.046 14.4 0.9 0.18 12.5 0.2 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat RNA_pol_Rpb1_1 PF04997.12 AET41361.1 - 4.5e-116 387.5 0.0 9.2e-116 386.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 AET41361.1 - 8.6e-108 359.8 0.2 1.3e-107 359.3 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 AET41361.1 - 2.3e-78 262.1 0.1 6e-78 260.8 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 AET41361.1 - 1.9e-62 210.5 0.4 5.1e-62 209.1 0.4 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 AET41361.1 - 1.4e-49 168.1 0.1 2.9e-48 163.8 0.0 2.6 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 AET41361.1 - 3.3e-48 163.1 4.0 7.9e-48 161.9 4.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 AET41361.1 - 1.4e-35 121.4 0.1 3.8e-35 120.1 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 AET41361.1 - 2.5e-14 52.8 321.2 0.38 11.2 10.3 16.1 3 1 26 29 29 29 27 RNA polymerase Rpb1 C-terminal repeat Chorion_1 PF01723.16 AET41361.1 - 5.3 7.0 6.7 13 5.7 6.7 1.6 1 0 0 1 1 1 0 Chorion protein BPL_N PF09825.9 AET41362.1 - 2.9e-118 395.2 0.0 3.5e-118 395.0 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 AET41362.1 - 1e-20 74.0 0.4 4e-20 72.0 0.4 1.9 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 AET41362.1 - 1.5e-12 47.2 0.0 2.6e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain DJ-1_PfpI PF01965.24 AET41362.1 - 0.0096 15.7 0.0 0.025 14.4 0.0 1.6 2 0 0 2 2 2 1 DJ-1/PfpI family CDP-OH_P_transf PF01066.21 AET41363.1 - 2.5e-14 53.8 1.2 5.3e-14 52.7 0.4 2.0 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Cpn60_TCP1 PF00118.24 AET41364.1 - 9.2e-143 476.4 13.3 1e-142 476.2 13.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family D123 PF07065.14 AET41365.1 - 4.9e-108 360.9 0.2 5.8e-108 360.7 0.2 1.1 1 0 0 1 1 1 1 D123 MHCassoc_trimer PF08831.10 AET41365.1 - 0.025 14.6 0.1 0.064 13.3 0.1 1.7 1 0 0 1 1 1 0 Class II MHC-associated invariant chain trimerisation domain R2K_3 PF14243.6 AET41365.1 - 0.19 11.7 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 FAD_binding_8 PF08022.12 AET41366.1 - 3.2e-22 78.7 0.0 6.3e-22 77.7 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 AET41366.1 - 1.9e-21 76.4 18.7 3.1e-21 75.8 12.9 2.5 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 AET41366.1 - 2.7e-15 56.8 0.0 5.5e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain CFEM PF05730.11 AET41366.1 - 0.21 11.7 1.7 0.62 10.2 1.7 1.8 1 0 0 1 1 1 0 CFEM domain Glyco_hydro_16 PF00722.21 AET41367.1 - 6.4e-46 156.0 0.2 9.6e-46 155.5 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Chitin_bind_1 PF00187.19 AET41367.1 - 2.3 8.7 10.9 4.4 7.9 10.9 1.4 1 0 0 1 1 1 0 Chitin recognition protein Coatomer_WDAD PF04053.14 AET41368.1 - 1.8e-133 445.9 4.2 2.7e-133 445.3 4.2 1.3 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 AET41368.1 - 9e-79 265.1 0.0 1.3e-78 264.6 0.0 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 AET41368.1 - 2.5e-41 138.9 17.9 1.7e-07 31.8 0.2 8.3 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET41368.1 - 1.5e-11 44.4 0.3 1.2e-05 25.5 0.0 5.8 3 2 6 9 9 9 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AET41368.1 - 5.1e-05 23.2 0.2 0.89 9.4 0.0 3.8 3 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A CNH PF00780.22 AET41368.1 - 0.001 18.7 0.1 0.0027 17.4 0.1 1.7 2 0 0 2 2 2 1 CNH domain Nup160 PF11715.8 AET41368.1 - 0.018 13.7 7.1 3.8 6.0 0.0 4.1 2 1 1 4 4 4 0 Nucleoporin Nup120/160 ENTH PF01417.20 AET41368.1 - 0.095 12.7 0.4 1.4 8.9 0.1 2.6 2 0 0 2 2 2 0 ENTH domain Ribosomal_L32e PF01655.18 AET41368.1 - 0.17 12.3 0.0 0.41 11.1 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L32 Tubulin PF00091.25 AET41369.1 - 1.5e-65 221.1 0.0 3.2e-65 220.0 0.0 1.6 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 AET41369.1 - 9.6e-29 100.1 0.1 2.4e-28 98.8 0.1 1.6 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 AET41369.1 - 9.2e-06 26.0 0.0 2.1e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 AET41369.1 - 0.03 13.5 0.0 0.048 12.8 0.0 1.3 1 0 0 1 1 1 0 Tubulin like Tubulin_3 PF14881.6 AET41369.1 - 0.11 12.2 0.0 0.27 10.9 0.0 1.7 1 0 0 1 1 1 0 Tubulin domain DUF2935 PF11155.8 AET41369.1 - 0.2 12.0 0.4 3.6 7.9 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF2935) DUF2013 PF09431.10 AET41370.1 - 2.9e-39 134.4 12.9 2.9e-39 134.4 12.9 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2013) DUF4018 PF13210.6 AET41370.1 - 0.01 15.6 0.2 0.01 15.6 0.2 1.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4018) HALZ PF02183.18 AET41371.1 - 0.035 14.3 5.6 0.036 14.3 0.1 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper GD_AH_C PF04295.13 AET41371.1 - 0.053 12.3 1.2 0.28 9.9 0.0 2.1 2 0 0 2 2 2 0 D-galactarate dehydratase / Altronate hydrolase, C terminus PilJ PF13675.6 AET41371.1 - 0.061 13.3 8.2 0.49 10.4 3.5 2.2 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Ribosomal_S8 PF00410.19 AET41371.1 - 0.25 11.3 1.8 0.25 11.3 0.4 1.8 2 0 0 2 2 2 0 Ribosomal protein S8 DUF1465 PF07323.12 AET41371.1 - 0.29 10.9 4.7 0.21 11.4 1.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1465) GIT_CC PF16559.5 AET41371.1 - 0.49 10.3 7.2 0.41 10.6 1.8 3.0 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Speriolin_N PF15058.6 AET41371.1 - 0.91 9.6 8.2 0.58 10.2 1.5 2.7 2 1 0 2 2 2 0 Speriolin N terminus bZIP_1 PF00170.21 AET41371.1 - 1.8 8.7 12.4 1.3 9.2 1.9 2.9 2 1 0 2 2 2 0 bZIP transcription factor YtxH PF12732.7 AET41371.1 - 2.6 8.6 5.8 14 6.3 0.3 2.7 2 1 1 3 3 3 0 YtxH-like protein FlaC_arch PF05377.11 AET41371.1 - 4.3 7.8 6.8 1.4 9.3 0.2 3.2 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) PCI PF01399.27 AET41372.1 - 1.4e-22 80.2 1.8 2.8e-22 79.2 0.0 2.4 3 0 0 3 3 3 1 PCI domain RPN5_C PF18098.1 AET41372.1 - 2.7e-15 56.2 3.3 8.9e-15 54.5 3.3 2.0 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain TPR_MalT PF17874.1 AET41372.1 - 0.024 14.0 0.2 0.06 12.7 0.0 1.7 2 0 0 2 2 2 0 MalT-like TPR region Nop14 PF04147.12 AET41373.1 - 1.2e-182 609.4 36.8 7.8e-101 338.7 5.1 2.0 1 1 1 2 2 2 2 Nop14-like family APG9 PF04109.16 AET41374.1 - 1.2e-194 647.8 18.0 1.4e-194 647.6 18.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 Sas10 PF09368.10 AET41375.1 - 8.4e-29 99.9 10.9 8.4e-29 99.9 10.9 2.6 3 0 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 AET41375.1 - 2.4e-05 24.9 0.6 0.0001 22.8 0.0 2.5 2 0 0 2 2 2 1 Sas10/Utp3/C1D family MutS_V PF00488.21 AET41376.1 - 1.3e-46 159.0 0.4 2.2e-46 158.3 0.4 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 AET41376.1 - 2.4e-25 89.9 1.2 6.3e-25 88.5 1.2 1.8 1 0 0 1 1 1 1 MutS domain III AAA_29 PF13555.6 AET41376.1 - 0.061 13.1 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF3785 PF12653.7 AET41376.1 - 0.26 11.4 5.7 0.35 11.0 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3785) Cyclin_N PF00134.23 AET41377.1 - 2.5e-42 143.6 1.7 3.3e-42 143.2 0.6 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 AET41377.1 - 3.4e-34 117.5 0.2 1.1e-33 115.8 0.1 2.0 2 0 0 2 2 2 1 Cyclin, C-terminal domain HLH PF00010.26 AET41378.1 - 8.5e-13 48.1 1.2 8.5e-13 48.1 1.2 2.5 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain Phage_int_SAM_1 PF02899.17 AET41378.1 - 0.1 12.9 0.2 0.49 10.7 0.0 2.2 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Got1 PF04178.12 AET41379.1 - 5e-32 110.7 13.7 5e-32 110.7 13.7 1.4 2 0 0 2 2 2 1 Got1/Sft2-like family Arrestin_C PF02752.22 AET41380.1 - 8e-10 39.3 6.7 1e-08 35.7 3.5 3.1 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Adaptin_N PF01602.20 AET41381.1 - 8.6e-99 331.5 17.7 1.4e-98 330.8 17.7 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 AET41381.1 - 2.1e-08 34.4 1.8 5.3e-08 33.1 1.8 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain DUF3385 PF11865.8 AET41381.1 - 0.38 10.6 7.2 0.21 11.5 0.4 3.5 2 2 0 2 2 2 0 Domain of unknown function (DUF3385) TB2_DP1_HVA22 PF03134.19 AET41382.1 - 5.3e-27 93.6 7.9 7.7e-27 93.0 7.9 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Peptidase_M22 PF00814.25 AET41383.1 - 3e-85 286.2 0.0 3.7e-85 285.9 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 AET41383.1 - 0.013 15.2 0.0 0.04 13.6 0.0 1.7 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus DASH_Spc34 PF08657.10 AET41384.1 - 1.2e-84 284.2 1.5 1.2e-84 284.2 1.5 1.4 2 0 0 2 2 2 1 DASH complex subunit Spc34 Lzipper-MIP1 PF14389.6 AET41384.1 - 0.015 15.6 2.4 0.04 14.2 2.4 1.8 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 Occludin_ELL PF07303.13 AET41384.1 - 0.12 13.1 4.5 0.091 13.5 1.7 2.3 2 1 0 2 2 2 0 Occludin homology domain PaaX_C PF08223.11 AET41384.1 - 0.13 12.5 0.2 0.27 11.5 0.2 1.5 1 0 0 1 1 1 0 PaaX-like protein C-terminal domain HALZ PF02183.18 AET41384.1 - 1.9 8.8 5.6 0.59 10.4 0.6 2.8 3 0 0 3 3 3 0 Homeobox associated leucine zipper WD40 PF00400.32 AET41385.1 - 1.2e-30 105.1 11.4 2.6e-06 28.0 0.4 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET41385.1 - 1.4e-08 34.9 0.0 0.046 14.0 0.0 4.9 3 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AET41385.1 - 6.5e-08 31.7 5.1 0.0028 16.4 0.1 4.8 2 2 3 5 5 5 3 Nucleoporin Nup120/160 Caf4 PF11615.8 AET41385.1 - 5.7e-05 23.0 0.0 0.34 10.9 0.0 2.6 2 0 0 2 2 2 2 CCR4-associated factor 4 Mdv1 PF11542.8 AET41385.1 - 8.1e-05 22.5 0.1 0.00016 21.6 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial division protein 1 BBS2_Mid PF14783.6 AET41385.1 - 9.7e-05 22.4 0.3 0.0054 16.7 0.0 3.0 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 AET41385.1 - 0.023 14.1 0.1 0.29 10.4 0.0 2.3 2 1 0 2 2 2 0 WD40-like domain UPF0489 PF12640.7 AET41385.1 - 0.085 13.1 0.1 0.32 11.2 0.1 2.0 1 0 0 1 1 1 0 UPF0489 domain DUF16 PF01519.16 AET41385.1 - 0.15 12.6 4.8 0.14 12.7 1.7 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 Nefa_Nip30_N PF10187.9 AET41386.1 - 1.9e-05 25.0 8.5 1.9e-05 25.0 8.5 1.7 1 1 1 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 MtlR PF05068.12 AET41386.1 - 0.012 15.6 0.3 0.017 15.1 0.3 1.3 1 0 0 1 1 1 0 Mannitol repressor Phage_lysis PF03245.13 AET41386.1 - 0.079 13.1 1.0 0.098 12.8 1.0 1.2 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein DnaJ PF00226.31 AET41387.1 - 3e-18 65.7 0.9 6.2e-18 64.7 0.9 1.6 1 0 0 1 1 1 1 DnaJ domain PigN PF04987.14 AET41388.1 - 8.8e-125 417.1 48.1 1.2e-124 416.7 48.1 1.2 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 AET41388.1 - 5.4e-12 46.0 1.9 3.4e-09 36.8 0.3 2.2 1 1 1 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 AET41388.1 - 6.6e-11 42.1 0.1 1.1e-10 41.4 0.1 1.5 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 AET41388.1 - 0.0001 21.8 0.0 0.00017 21.1 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Pkinase PF00069.25 AET41389.1 - 4.6e-71 239.3 0.0 5.5e-71 239.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET41389.1 - 2.1e-39 135.4 0.0 2.7e-39 135.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET41389.1 - 8.2e-06 25.3 0.0 1.7e-05 24.3 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 AET41389.1 - 0.026 13.9 0.0 0.042 13.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 AET41389.1 - 0.05 12.5 0.0 0.062 12.2 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 AET41389.1 - 0.079 12.0 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 AET41389.1 - 0.16 11.9 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family L51_S25_CI-B8 PF05047.16 AET41390.1 - 1.9e-12 46.9 0.3 3e-12 46.3 0.3 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Peripla_BP_7 PF18610.1 AET41390.1 - 0.014 15.5 0.0 0.028 14.6 0.0 1.6 1 0 0 1 1 1 0 Periplasmic binding protein domain LrgB PF04172.16 AET41391.1 - 2.6e-45 154.6 3.1 2.6e-45 154.6 3.1 2.9 3 1 0 3 3 3 1 LrgB-like family LrgA PF03788.14 AET41391.1 - 0.00079 19.3 3.4 0.00079 19.3 3.4 2.9 3 0 0 3 3 3 1 LrgA family Pkinase PF00069.25 AET41392.1 - 3.2e-43 148.0 0.0 1.2e-42 146.1 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET41392.1 - 2e-18 66.6 0.0 1.3e-17 63.9 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 AET41392.1 - 0.092 12.0 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Ribosomal_L14 PF00238.19 AET41393.1 - 2.8e-43 146.9 1.7 3.2e-43 146.7 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Mitoc_L55 PF09776.9 AET41393.1 - 0.078 12.7 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L55 Pkinase PF00069.25 AET41394.1 - 2e-35 122.4 0.0 7e-22 78.0 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AET41394.1 - 2.3e-21 76.2 0.0 6.5e-18 64.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 AET41394.1 - 0.007 15.7 0.0 0.48 9.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 AET41394.1 - 0.049 13.0 0.1 0.094 12.1 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family UcrQ PF02939.16 AET41395.1 - 2.7e-31 107.3 0.8 4.1e-31 106.7 0.8 1.3 1 0 0 1 1 1 1 UcrQ family Crl PF07417.12 AET41395.1 - 0.059 13.4 0.8 0.61 10.1 0.0 2.2 2 0 0 2 2 2 0 Sigma factor-binding transcriptional regulator Crl polyprenyl_synt PF00348.17 AET41396.1 - 7.1e-93 310.4 0.0 8.5e-93 310.1 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Ebp2 PF05890.12 AET41397.1 - 3.7e-85 285.7 31.2 3.7e-85 285.7 31.2 2.2 1 1 1 2 2 2 1 Eukaryotic rRNA processing protein EBP2 Cbl_N PF02262.16 AET41397.1 - 0.015 15.3 1.1 0.04 13.9 1.1 1.7 1 0 0 1 1 1 0 CBL proto-oncogene N-terminal domain 1 PP28 PF10252.9 AET41397.1 - 0.016 15.7 9.7 0.016 15.7 9.7 3.1 3 0 0 3 3 3 0 Casein kinase substrate phosphoprotein PP28 GTP_EFTU PF00009.27 AET41398.1 - 2.3e-33 115.4 0.0 3.3e-33 114.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 AET41398.1 - 6.4e-19 67.8 0.0 1.4e-18 66.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 AET41398.1 - 2.2e-14 53.3 0.0 7.8e-14 51.5 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV EFTUD2 PF16004.5 AET41398.1 - 2.5e-08 34.6 9.7 2.1e-06 28.3 9.7 2.3 1 1 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus GTP_EFTU_D2 PF03144.25 AET41398.1 - 1e-06 29.0 0.1 2.3e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 AET41398.1 - 8.6e-06 25.8 0.0 2.4e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 AET41398.1 - 0.0057 16.7 0.1 0.025 14.7 0.0 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase DUF4909 PF16253.5 AET41398.1 - 0.056 13.3 0.2 0.15 11.9 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4909) AA_permease PF00324.21 AET41399.1 - 4.3e-53 180.6 39.3 5.6e-53 180.2 39.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AET41399.1 - 6.5e-31 107.6 39.5 7.8e-31 107.3 39.5 1.0 1 0 0 1 1 1 1 Amino acid permease Zip PF02535.22 AET41400.1 - 5.1e-21 75.3 5.9 9.5e-21 74.4 5.3 1.8 1 1 0 1 1 1 1 ZIP Zinc transporter H_PPase PF03030.16 AET41400.1 - 0.054 12.1 0.9 0.16 10.6 0.1 1.9 2 0 0 2 2 2 0 Inorganic H+ pyrophosphatase Metaviral_G PF09595.10 AET41400.1 - 0.086 12.9 0.2 0.15 12.1 0.2 1.3 1 0 0 1 1 1 0 Metaviral_G glycoprotein Longin_2 PF18639.1 AET41401.1 - 2.6e-58 196.5 0.0 5e-58 195.6 0.0 1.5 1 0 0 1 1 1 1 Yeast longin domain SRI PF08236.11 AET41402.1 - 2.3e-24 85.4 4.1 2.3e-24 85.4 4.1 2.6 3 1 0 3 3 3 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.28 AET41402.1 - 1.3e-18 68.0 0.9 1.3e-18 68.0 0.9 4.1 3 2 0 3 3 3 1 SET domain AWS PF17907.1 AET41402.1 - 4.1e-15 55.5 9.8 4.1e-15 55.5 9.8 3.1 3 0 0 3 3 3 1 AWS domain Med26 PF08711.11 AET41402.1 - 9.1e-06 25.6 0.6 3e-05 24.0 0.6 1.9 1 0 0 1 1 1 1 TFIIS helical bundle-like domain CCDC66 PF15236.6 AET41402.1 - 1.8 8.4 32.1 11 5.8 31.7 2.1 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 66 DUF2252 PF10009.9 AET41402.1 - 2.6 7.0 9.6 3 6.8 8.1 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2252) CemA PF03040.14 AET41402.1 - 4.2 7.2 15.5 4 7.3 10.9 2.3 2 0 0 2 2 2 0 CemA family Laps PF10169.9 AET41402.1 - 6.7 7.3 28.3 2.9 8.5 22.8 2.5 2 0 0 2 2 2 0 Learning-associated protein 7tm_1 PF00001.21 AET41403.1 - 0.0074 15.6 0.7 0.0074 15.6 0.7 1.6 1 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) GrpB PF04229.14 AET41403.1 - 0.02 15.1 0.1 0.027 14.7 0.1 1.1 1 0 0 1 1 1 0 GrpB protein DUF2401 PF10287.9 AET41404.1 - 1.2e-78 263.9 0.0 1.6e-78 263.5 0.0 1.1 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 AET41404.1 - 1.1e-21 77.1 0.0 2.3e-21 76.0 0.0 1.6 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) STE3 PF02076.15 AET41405.1 - 9.6e-84 281.0 23.4 1.2e-83 280.7 23.4 1.1 1 0 0 1 1 1 1 Pheromone A receptor Peptidase_M20 PF01546.28 AET41406.1 - 5.8e-31 107.8 0.0 9.1e-31 107.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 AET41406.1 - 2.6e-13 49.8 0.0 4.3e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain PX PF00787.24 AET41406.1 - 0.061 13.3 0.2 0.16 11.9 0.2 1.7 2 0 0 2 2 2 0 PX domain DnaJ-X PF14308.6 AET41406.1 - 0.14 11.6 0.1 0.34 10.3 0.1 1.6 1 0 0 1 1 1 0 X-domain of DnaJ-containing Rep_fac-A_3 PF08661.11 AET41408.1 - 1.1e-28 99.6 0.0 1.2e-28 99.5 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 KRE9 PF05390.11 AET41409.1 - 7.1e-37 126.3 6.9 1.4e-36 125.3 6.9 1.5 1 0 0 1 1 1 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.9 AET41409.1 - 1.3e-07 32.2 0.0 7.6e-07 29.8 0.0 2.1 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SWIRM PF04433.17 AET41410.1 - 3e-28 98.0 0.3 7.4e-28 96.7 0.3 1.7 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 AET41410.1 - 8.5e-24 83.3 5.4 8.5e-24 83.3 5.4 2.1 3 0 0 3 3 3 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 AET41410.1 - 6.8e-11 42.2 0.1 1.4e-10 41.2 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AET41410.1 - 7.8e-10 38.9 0.1 2.6e-09 37.2 0.1 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF743 PF05332.11 AET41410.1 - 0.00046 20.2 0.9 0.0013 18.8 0.9 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF743) SANT_DAMP1_like PF16282.5 AET41410.1 - 0.13 12.4 0.2 0.94 9.7 0.0 2.4 2 0 0 2 2 2 0 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_7 PF15963.5 AET41410.1 - 0.18 11.7 0.0 0.18 11.7 0.0 3.0 4 0 0 4 4 4 0 Myb DNA-binding like Prefoldin_2 PF01920.20 AET41411.1 - 1.2e-15 57.4 9.2 1.4e-15 57.1 9.2 1.1 1 0 0 1 1 1 1 Prefoldin subunit DUF4510 PF14971.6 AET41411.1 - 0.15 12.4 0.6 0.15 12.4 0.6 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4510) ATP12 PF07542.11 AET41412.1 - 4.6e-30 104.3 0.0 9.4e-30 103.3 0.0 1.5 1 0 0 1 1 1 1 ATP12 chaperone protein DUF1664 PF07889.12 AET41413.1 - 0.13 12.3 0.3 0.26 11.4 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Glyco_transf_34 PF05637.12 AET41414.1 - 2.8e-42 145.1 0.1 3.5e-42 144.8 0.1 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF3989 PF13150.6 AET41414.1 - 0.15 11.8 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) Gon7 PF08738.10 AET41415.1 - 9e-42 141.6 2.5 1.1e-41 141.3 2.5 1.0 1 0 0 1 1 1 1 Gon7 family SSB PF00436.25 AET41416.1 - 7.3e-19 67.7 0.0 8.8e-19 67.5 0.0 1.1 1 0 0 1 1 1 1 Single-strand binding protein family MLD PF11647.8 AET41417.1 - 0.034 14.4 0.0 0.13 12.6 0.0 2.0 1 0 0 1 1 1 0 Membrane Localization Domain muHD PF10291.9 AET41418.1 - 2.1e-68 230.6 0.3 6.4e-68 229.0 0.0 1.9 2 0 0 2 2 2 1 Muniscin C-terminal mu homology domain Baculo_PEP_C PF04513.12 AET41418.1 - 0.027 14.5 0.1 0.086 12.9 0.1 1.9 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Occludin_ELL PF07303.13 AET41418.1 - 0.32 11.7 3.1 0.25 12.1 0.4 2.3 2 0 0 2 2 2 0 Occludin homology domain Mannosyl_trans3 PF11051.8 AET41419.1 - 1.5e-79 267.2 0.0 2.3e-79 266.6 0.0 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative Pkinase PF00069.25 AET41420.1 - 3.5e-47 161.0 0.0 5.4e-47 160.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET41420.1 - 2.1e-27 96.1 0.0 3.2e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TetR_C_37 PF18665.1 AET41420.1 - 0.02 15.5 0.2 0.041 14.5 0.2 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF4299 PF14132.6 AET41420.1 - 0.089 12.2 0.1 0.14 11.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4299) MOZART2 PF12926.7 AET41420.1 - 0.12 12.0 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated Ribosomal_L39 PF00832.20 AET41421.1 - 4.1e-22 77.5 11.2 4.9e-22 77.3 11.2 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein PI_PP_I PF18363.1 AET41421.1 - 0.0051 17.0 0.1 0.0051 17.0 0.1 1.1 1 0 0 1 1 1 1 Phosphoinositide phosphatase insertion domain Ribosomal_S8 PF00410.19 AET41422.1 - 6.6e-24 84.3 0.2 1.1e-23 83.6 0.2 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 Ribosomal_S11 PF00411.19 AET41423.1 - 2e-45 153.7 2.2 2.5e-45 153.4 2.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 BKACE PF05853.12 AET41423.1 - 0.088 12.1 0.4 0.14 11.5 0.4 1.3 1 0 0 1 1 1 0 beta-keto acid cleavage enzyme SOP4 PF17081.5 AET41424.1 - 1.1e-91 306.0 0.2 1.3e-91 305.8 0.2 1.0 1 0 0 1 1 1 1 Suppressor of PMA 1-7 protein DUF2012 PF09430.10 AET41424.1 - 0.099 12.8 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2012) Beach PF02138.18 AET41425.1 - 4.6e-118 393.6 1.6 1.4e-117 392.0 0.0 2.2 2 0 0 2 2 2 1 Beige/BEACH domain PH_BEACH PF14844.6 AET41425.1 - 1.2e-08 35.0 0.0 3.1e-08 33.6 0.0 1.8 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 AET41425.1 - 0.004 17.3 0.0 0.014 15.5 0.0 1.8 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Cdc6_C PF09079.11 AET41426.1 - 5.2e-11 42.4 0.2 1.2e-10 41.2 0.2 1.6 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain AAA PF00004.29 AET41426.1 - 2.1e-10 41.1 0.2 6.3e-10 39.6 0.2 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AET41426.1 - 3.2e-10 40.4 0.0 1.1e-09 38.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AET41426.1 - 7.2e-08 33.0 0.0 2.3e-07 31.4 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 AET41426.1 - 0.013 14.8 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 AET41426.1 - 0.015 15.6 0.9 0.13 12.6 0.9 2.3 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 AET41426.1 - 0.017 15.1 0.0 0.051 13.5 0.0 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea PIF1 PF05970.14 AET41426.1 - 0.028 13.6 0.5 0.42 9.7 0.1 2.1 2 0 0 2 2 2 0 PIF1-like helicase T2SSE PF00437.20 AET41426.1 - 0.029 13.5 0.0 0.065 12.3 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_7 PF12775.7 AET41426.1 - 0.035 13.6 0.1 11 5.5 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_11 PF13086.6 AET41426.1 - 0.036 13.8 2.7 0.08 12.7 2.7 1.9 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 AET41426.1 - 0.039 13.7 1.9 0.41 10.4 0.7 2.7 2 1 0 2 2 2 0 DEAD/DEAH box helicase RNA_helicase PF00910.22 AET41426.1 - 0.042 14.2 0.1 0.65 10.4 0.1 2.7 1 1 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 AET41426.1 - 0.074 12.8 0.2 0.18 11.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain sCache_3_2 PF17203.4 AET41426.1 - 0.14 12.2 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Single cache domain 3 NACHT PF05729.12 AET41426.1 - 0.19 11.6 0.7 29 4.5 0.1 2.9 2 1 1 3 3 3 0 NACHT domain Myb_DNA-binding PF00249.31 AET41427.1 - 2.4e-16 59.7 0.0 9.9e-07 28.9 0.0 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AET41427.1 - 3e-05 24.2 1.8 0.029 14.6 0.1 3.5 3 0 0 3 3 3 2 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 AET41427.1 - 0.089 13.0 0.1 0.43 10.8 0.1 2.2 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 ELO PF01151.18 AET41428.1 - 2e-63 214.3 24.3 2.4e-63 214.0 24.3 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family RNase_PH PF01138.21 AET41429.1 - 1.2e-23 84.1 0.6 2.3e-22 79.9 0.2 2.6 2 1 0 2 2 2 1 3' exoribonuclease family, domain 1 PfkB PF00294.24 AET41430.1 - 1.4e-44 152.6 0.1 6.9e-44 150.4 0.1 1.8 1 1 0 1 1 1 1 pfkB family carbohydrate kinase UCH PF00443.29 AET41431.1 - 2.3e-78 263.2 0.7 5.6e-78 262.0 0.7 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AET41431.1 - 3.4e-14 53.2 1.6 2e-06 27.6 0.5 3.4 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 AET41431.1 - 2.7e-05 24.7 6.6 0.00073 20.1 0.2 4.5 3 1 0 3 3 3 1 DUSP domain CW_binding_1 PF01473.20 AET41431.1 - 0.42 11.0 2.7 1.4 9.3 2.7 2.0 1 0 0 1 1 1 0 Putative cell wall binding repeat SPX PF03105.19 AET41432.1 - 3.7e-41 142.3 19.8 5.1e-39 135.3 19.8 2.7 1 1 0 1 1 1 1 SPX domain Na_sulph_symp PF00939.19 AET41432.1 - 8.7e-23 81.1 47.1 1.2e-22 80.7 47.1 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 AET41432.1 - 4.9e-22 78.5 67.6 1.1e-19 70.7 36.8 2.2 1 1 1 2 2 2 2 Citrate transporter Mt_ATP-synt_B PF05405.14 AET41432.1 - 1.8 8.2 7.5 0.98 9.0 0.1 2.9 3 0 0 3 3 3 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Aconitase PF00330.20 AET41433.1 - 2.4e-148 495.0 0.0 3.1e-148 494.6 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 AET41433.1 - 1e-42 145.6 0.0 1.7e-42 144.9 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain RasGEF PF00617.19 AET41434.1 - 4.9e-42 144.1 2.5 1.5e-40 139.3 0.9 2.8 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 AET41434.1 - 8.9e-15 54.8 0.5 5.4e-14 52.3 0.5 2.4 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 AET41434.1 - 0.0011 18.5 0.1 0.0035 16.9 0.0 1.9 2 0 0 2 2 2 1 SH3 domain KHA PF11834.8 AET41434.1 - 0.0092 16.0 0.1 4.9 7.3 0.0 2.7 2 0 0 2 2 2 2 KHA, dimerisation domain of potassium ion channel Ish1 PF10281.9 AET41435.1 - 1.5e-38 130.8 31.9 4.4e-13 49.3 2.9 7.0 6 0 0 6 6 6 6 Putative stress-responsive nuclear envelope protein HeH PF12949.7 AET41435.1 - 0.00023 20.8 0.0 1.5 8.6 0.0 3.8 4 0 0 4 4 4 2 HeH/LEM domain YtxH PF12732.7 AET41435.1 - 0.0019 18.7 14.7 0.66 10.5 2.6 5.4 4 2 0 4 4 4 2 YtxH-like protein SAP PF02037.27 AET41435.1 - 0.0026 17.5 0.0 26 4.7 0.0 4.9 5 0 0 5 5 5 0 SAP domain Apolipoprotein PF01442.18 AET41435.1 - 0.022 14.6 2.9 0.095 12.6 0.0 3.0 3 0 0 3 3 3 0 Apolipoprotein A1/A4/E domain DUF4230 PF14014.6 AET41435.1 - 0.42 10.9 4.5 5.1 7.4 0.0 4.0 3 2 2 5 5 5 0 Protein of unknown function (DUF4230) DUF883 PF05957.13 AET41435.1 - 0.72 10.5 3.7 12 6.6 0.2 3.4 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) COX14 PF14880.6 AET41436.1 - 7.7e-25 86.5 2.9 8.2e-25 86.4 2.9 1.0 1 0 0 1 1 1 1 Cytochrome oxidase c assembly Rtf2 PF04641.12 AET41437.1 - 6e-19 68.4 2.8 3e-18 66.1 2.8 1.8 1 1 0 1 1 1 1 Rtf2 RING-finger Vinculin PF01044.19 AET41437.1 - 0.047 11.9 0.1 0.062 11.5 0.1 1.1 1 0 0 1 1 1 0 Vinculin family zf-CCCH PF00642.24 AET41438.1 - 2.6e-08 33.6 13.8 8.7e-06 25.5 3.2 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AET41438.1 - 8.9e-08 31.9 10.2 0.00025 21.0 2.4 2.5 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 AET41438.1 - 8.1e-05 23.3 2.3 0.055 14.2 0.2 2.4 2 0 0 2 2 2 2 Torus domain RRM_1 PF00076.22 AET41438.1 - 0.00057 19.7 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_3 PF15663.5 AET41438.1 - 0.00076 19.7 3.6 0.58 10.4 0.3 2.4 2 0 0 2 2 2 2 Zinc-finger containing family zf-CCCH_4 PF18044.1 AET41438.1 - 0.00091 19.0 9.8 0.013 15.3 1.2 2.7 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 AET41438.1 - 0.38 11.3 6.8 1.5 9.4 1.2 2.6 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Proteasome PF00227.26 AET41439.1 - 3.4e-59 199.5 0.0 4.3e-59 199.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AET41439.1 - 2.1e-09 36.8 0.7 5e-09 35.7 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Utp14 PF04615.13 AET41440.1 - 2.1e-196 654.9 71.4 2.1e-196 654.9 71.4 1.8 2 0 0 2 2 2 1 Utp14 protein Prefoldin PF02996.17 AET41441.1 - 5.1e-28 97.4 1.1 7.7e-28 96.8 1.1 1.3 1 0 0 1 1 1 1 Prefoldin subunit GIT_CC PF16559.5 AET41441.1 - 0.018 14.9 3.6 3.7 7.5 0.0 2.5 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4241 PF14025.6 AET41441.1 - 0.023 15.0 0.7 0.035 14.4 0.3 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4241) Uds1 PF15456.6 AET41441.1 - 0.066 13.4 8.6 0.33 11.1 6.2 2.1 1 1 1 2 2 2 0 Up-regulated During Septation Fib_alpha PF08702.10 AET41441.1 - 0.072 13.3 9.3 0.2 11.9 0.3 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family PHM7_cyt PF14703.6 AET41441.1 - 0.27 11.5 8.3 0.13 12.5 4.1 1.9 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter DUF1664 PF07889.12 AET41441.1 - 0.56 10.3 6.7 1.2 9.2 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) E2F_CC-MB PF16421.5 AET41441.1 - 0.75 10.2 8.5 3 8.3 0.0 2.2 2 0 0 2 2 2 0 E2F transcription factor CC-MB domain Plk4_PB2 PF18409.1 AET41441.1 - 1 10.1 7.1 1.4 9.7 2.2 2.1 2 0 0 2 2 2 0 Polo-like Kinase 4 Polo Box 2 PRKCSH-like PF12999.7 AET41441.1 - 1.4 8.6 5.3 0.34 10.7 2.0 1.7 2 0 0 2 2 2 0 Glucosidase II beta subunit-like ISG65-75 PF11727.8 AET41441.1 - 2 7.5 9.9 0.34 10.1 5.7 1.7 2 0 0 2 2 2 0 Invariant surface glycoprotein Rad10 PF03834.14 AET41442.1 - 1e-37 128.6 0.1 1.5e-37 128.1 0.1 1.2 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) CNOT1_HEAT PF16418.5 AET41442.1 - 0.095 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 HEAT repeat Asn_synthase PF00733.21 AET41443.1 - 7.4e-20 71.9 0.0 2.8e-10 40.4 0.0 2.3 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 AET41443.1 - 2.8e-10 40.2 0.3 1.3e-07 31.5 0.1 3.7 2 2 1 3 3 3 1 Glutamine amidotransferase domain GATase_6 PF13522.6 AET41443.1 - 1.8e-08 34.7 0.2 1.3e-06 28.6 0.0 3.2 3 1 0 3 3 3 1 Glutamine amidotransferase domain DUF3700 PF12481.8 AET41443.1 - 0.013 14.9 0.0 0.029 13.8 0.0 1.5 1 0 0 1 1 1 0 Aluminium induced protein ERO1 PF04137.15 AET41444.1 - 4.8e-122 407.6 0.1 6.6e-122 407.1 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) TFIID-18kDa PF02269.16 AET41445.1 - 1.8e-30 104.8 0.0 2.9e-30 104.2 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Histone PF00125.24 AET41445.1 - 0.057 13.8 1.4 0.28 11.6 0.0 2.5 3 0 0 3 3 3 0 Core histone H2A/H2B/H3/H4 TAF PF02969.17 AET41445.1 - 0.1 12.8 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) Fungal_trans_2 PF11951.8 AET41446.1 - 5.3e-105 351.4 3.4 7.4e-105 350.9 3.4 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AET41446.1 - 2e-12 47.0 6.2 4.7e-12 45.8 6.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peroxin-3 PF04882.12 AET41448.1 - 4.6e-106 355.6 13.4 5.6e-85 286.1 4.7 2.0 1 1 1 2 2 2 2 Peroxin-3 Foamy_BEL PF03274.14 AET41448.1 - 0.05 12.9 0.0 0.083 12.2 0.0 1.3 1 0 0 1 1 1 0 Foamy virus BEL 1/2 protein Skp1 PF01466.19 AET41449.1 - 4.2e-24 84.4 0.3 4.2e-24 84.4 0.3 1.9 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 AET41449.1 - 7.2e-14 51.7 0.2 1.2e-06 28.6 0.1 2.5 2 0 0 2 2 2 2 Skp1 family, tetramerisation domain VASt PF16016.5 AET41450.1 - 5.9e-68 228.1 0.9 1.1e-33 116.8 0.0 3.1 3 0 0 3 3 3 2 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 AET41450.1 - 8.6e-28 96.5 0.0 9.3e-27 93.2 0.0 2.4 2 0 0 2 2 2 1 GRAM domain Ribonuc_2-5A PF06479.12 AET41451.1 - 6e-43 146.1 0.3 1.4e-42 144.8 0.3 1.7 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.25 AET41451.1 - 2.8e-39 135.1 0.0 1.8e-29 103.0 0.1 2.7 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AET41451.1 - 3.2e-20 72.5 0.0 1.2e-17 64.1 0.0 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase PQQ PF01011.21 AET41451.1 - 8.3e-06 25.5 0.8 0.11 12.5 0.1 3.0 3 0 0 3 3 3 2 PQQ enzyme repeat Kdo PF06293.14 AET41451.1 - 0.00029 20.2 0.1 0.00053 19.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PQQ_2 PF13360.6 AET41451.1 - 0.00083 19.0 0.0 0.029 14.0 0.0 2.2 1 1 1 2 2 2 2 PQQ-like domain Zip PF02535.22 AET41451.1 - 0.13 11.5 0.5 0.26 10.4 0.5 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 AET41451.1 - 1.5 7.0 9.7 2.3 6.4 9.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 AET41451.1 - 2.5 6.8 6.8 4.5 5.9 6.8 1.3 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 AET41451.1 - 3.4 7.4 14.2 6.3 6.5 14.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Cnd3 PF12719.7 AET41452.1 - 2.6e-94 315.7 3.7 2.6e-94 315.7 3.7 2.9 3 1 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 AET41452.1 - 4e-10 40.0 0.1 3.4e-06 27.4 0.0 3.8 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.22 AET41452.1 - 1.3e-08 34.4 2.9 0.36 11.2 0.0 5.8 6 0 0 6 6 6 3 HEAT repeat Cnd1 PF12717.7 AET41452.1 - 1.6e-05 25.0 10.8 0.00068 19.7 0.3 4.5 3 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 AET41452.1 - 0.067 13.8 0.6 1.6 9.4 0.0 3.5 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region CNOT11 PF10155.9 AET41452.1 - 0.82 9.8 6.8 50 4.1 0.2 4.6 3 1 1 4 4 4 0 CCR4-NOT transcription complex subunit 11 ABA_GPCR PF12430.8 AET41453.1 - 2.2e-58 197.0 3.7 2.2e-58 197.0 3.7 2.3 2 1 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 AET41453.1 - 3.7e-15 55.8 0.7 1.2e-14 54.1 0.7 1.9 1 0 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal DUF3810 PF12725.7 AET41453.1 - 2.5 7.4 5.9 2.2 7.6 3.9 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) FYVE PF01363.21 AET41454.1 - 3.5e-20 71.9 21.8 9.8e-16 57.7 2.3 2.7 3 0 0 3 3 3 2 FYVE zinc finger Rbsn PF11464.8 AET41454.1 - 4.3e-15 55.2 1.3 8.8e-15 54.2 1.3 1.6 1 0 0 1 1 1 1 Rabenosyn Rab binding domain zf-C2H2_2 PF12756.7 AET41454.1 - 1.9 8.9 9.9 0.73 10.2 2.1 3.2 2 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Rad50_zn_hook PF04423.14 AET41454.1 - 4 7.4 8.7 1.9 8.4 0.1 4.0 4 0 0 4 4 4 0 Rad50 zinc hook motif Elf1 PF05129.13 AET41454.1 - 6 7.0 10.3 12 6.0 0.9 3.6 3 1 0 3 3 3 0 Transcription elongation factor Elf1 like MIF4G PF02854.19 AET41455.1 - 1.3e-35 123.0 31.7 1.2e-18 67.6 0.1 3.8 4 1 0 4 4 4 3 MIF4G domain Upf2 PF04050.14 AET41455.1 - 1.5e-26 93.7 5.1 1.5e-26 93.7 5.1 2.5 1 1 0 2 2 2 1 Up-frameshift suppressor 2 Mt_ATP-synt_D PF05873.12 AET41455.1 - 0.036 13.9 0.1 0.036 13.9 0.1 2.4 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) Nop14 PF04147.12 AET41455.1 - 0.087 11.0 34.5 0.2 9.8 34.5 1.6 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 AET41455.1 - 2.5 7.5 41.3 0.34 10.3 37.0 1.7 2 0 0 2 2 2 0 SDA1 CDC45 PF02724.14 AET41455.1 - 4.5 5.4 32.7 7.4 4.7 32.7 1.2 1 0 0 1 1 1 0 CDC45-like protein SpoIIE PF07228.12 AET41456.1 - 5.1e-30 104.8 0.0 6.9e-30 104.4 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 AET41456.1 - 2.5e-05 24.0 0.3 0.0029 17.3 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PPC PF04151.15 AET41456.1 - 0.87 10.7 5.2 1.6 9.9 0.2 2.5 2 0 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain ATP-synt_E PF05680.12 AET41457.1 - 1.8e-19 69.9 0.1 2e-19 69.7 0.1 1.0 1 0 0 1 1 1 1 ATP synthase E chain PBP PF01161.20 AET41458.1 - 1.9e-06 28.2 0.1 3.6e-06 27.3 0.1 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Peptidase_M1 PF01433.20 AET41459.1 - 2.8e-72 242.8 0.5 4.4e-72 242.2 0.5 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 AET41459.1 - 1.3e-47 162.4 0.2 3.3e-46 157.8 0.1 2.4 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain ERAP1_C PF11838.8 AET41459.1 - 4e-44 151.4 0.0 6.9e-44 150.7 0.0 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Abhydrolase_6 PF12697.7 AET41460.1 - 4.9e-16 60.0 0.0 9.3e-16 59.1 0.0 1.4 2 0 0 2 2 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 AET41460.1 - 3e-12 46.7 0.0 4.3e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AET41460.1 - 1.4e-08 34.3 0.0 2.1e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PAF-AH_p_II PF03403.13 AET41460.1 - 0.00016 20.4 0.2 0.039 12.5 0.1 2.2 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II LIDHydrolase PF10230.9 AET41460.1 - 0.00027 20.6 0.1 0.00041 20.0 0.1 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase BAAT_C PF08840.11 AET41460.1 - 0.0042 17.0 0.0 1 9.2 0.1 2.6 3 0 0 3 3 3 1 BAAT / Acyl-CoA thioester hydrolase C terminal Lipase_3 PF01764.25 AET41460.1 - 0.0045 16.9 0.1 0.021 14.7 0.1 2.0 2 1 0 2 2 2 1 Lipase (class 3) DUF676 PF05057.14 AET41460.1 - 0.0055 16.2 0.0 0.0095 15.5 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Thioesterase PF00975.20 AET41460.1 - 0.0081 16.3 0.1 0.26 11.4 0.1 2.3 1 1 0 1 1 1 1 Thioesterase domain VirJ PF06057.11 AET41460.1 - 0.014 15.3 0.0 0.088 12.7 0.0 1.9 2 0 0 2 2 2 0 Bacterial virulence protein (VirJ) Ser_hydrolase PF06821.13 AET41460.1 - 0.014 15.2 0.0 0.16 11.8 0.1 2.1 2 0 0 2 2 2 0 Serine hydrolase PGAP1 PF07819.13 AET41460.1 - 0.021 14.5 0.4 0.053 13.2 0.4 1.7 1 1 0 1 1 1 0 PGAP1-like protein Lactamase_B_6 PF16661.5 AET41460.1 - 0.038 13.4 0.1 0.08 12.4 0.0 1.5 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily domain DUF2974 PF11187.8 AET41460.1 - 0.069 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) CN_hydrolase PF00795.22 AET41461.1 - 8.2e-42 143.3 0.0 1.1e-41 142.9 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 AET41461.1 - 4.8e-21 75.0 0.0 1.2e-20 73.7 0.0 1.6 1 1 0 1 1 1 1 NAD synthase Asparaginase PF00710.20 AET41462.1 - 6.1e-54 182.5 0.1 1.7e-53 181.0 0.0 1.8 2 0 0 2 2 2 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 AET41462.1 - 1.6e-20 73.5 0.0 3.4e-20 72.4 0.0 1.6 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ribosomal_L19 PF01245.20 AET41462.1 - 0.011 15.7 0.0 24 4.9 0.0 3.4 3 0 0 3 3 3 0 Ribosomal protein L19 Oxysterol_BP PF01237.18 AET41463.1 - 9.3e-103 343.9 1.0 9.3e-102 340.6 1.0 2.2 1 1 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 AET41463.1 - 8.1e-32 109.4 0.4 2.7e-31 107.7 0.4 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 AET41463.1 - 0.007 16.9 0.8 0.024 15.2 0.8 2.0 1 0 0 1 1 1 1 PH domain DASH_Dad4 PF08650.10 AET41464.1 - 6.8e-32 109.3 6.1 7.6e-32 109.1 6.1 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 DUF3251 PF11622.8 AET41464.1 - 0.0044 16.7 0.2 0.0051 16.5 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3251) NPV_P10 PF05531.12 AET41464.1 - 0.019 15.4 0.1 0.021 15.2 0.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Prenyltransf PF01255.19 AET41464.1 - 0.024 14.2 0.2 0.024 14.1 0.2 1.1 1 0 0 1 1 1 0 Putative undecaprenyl diphosphate synthase DASH_Dam1 PF08653.10 AET41464.1 - 0.04 13.7 0.2 0.059 13.2 0.2 1.3 1 0 0 1 1 1 0 DASH complex subunit Dam1 DivIC PF04977.15 AET41464.1 - 0.05 13.4 0.5 0.073 12.9 0.5 1.2 1 0 0 1 1 1 0 Septum formation initiator WD40_alt PF14077.6 AET41464.1 - 0.12 12.2 0.3 0.25 11.2 0.3 1.5 1 0 0 1 1 1 0 Alternative WD40 repeat motif Nop10p PF04135.12 AET41465.1 - 3.5e-21 75.0 0.2 3.9e-21 74.8 0.2 1.0 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family PD40 PF07676.12 AET41465.1 - 0.24 11.4 0.8 5.9 7.0 0.0 2.4 2 1 0 2 2 2 0 WD40-like Beta Propeller Repeat zf-SAP30 PF13866.6 AET41466.1 - 0.13 12.3 0.7 0.31 11.2 0.4 1.7 1 1 1 2 2 2 0 SAP30 zinc-finger TORC_M PF12885.7 AET41466.1 - 0.23 11.4 0.1 0.35 10.8 0.1 1.2 1 0 0 1 1 1 0 Transducer of regulated CREB activity middle domain TPR_12 PF13424.6 AET41467.1 - 0.00046 20.4 0.0 0.062 13.6 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 AET41467.1 - 0.0023 17.9 0.5 5.2 7.4 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 AET41467.1 - 0.0052 16.5 0.5 17 5.4 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat DnaJ PF00226.31 AET41467.1 - 0.046 13.8 0.0 0.2 11.8 0.0 2.1 1 0 0 1 1 1 0 DnaJ domain ANAPC3 PF12895.7 AET41467.1 - 0.054 13.7 0.9 4.9 7.4 0.0 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 SQHop_cyclase_C PF13243.6 AET41468.1 - 4.3e-43 147.6 0.1 4.7e-42 144.2 0.0 2.2 2 1 0 2 2 2 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 AET41468.1 - 2.8e-34 118.6 0.0 3.8e-30 105.0 0.0 3.3 3 0 0 3 3 3 2 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 AET41468.1 - 1.7e-20 72.5 2.4 2.2e-07 30.5 0.7 4.6 5 0 0 5 5 5 3 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.10 AET41468.1 - 0.00031 20.2 1.7 0.025 13.9 0.0 3.8 3 2 1 4 4 4 1 Pectic acid lyase NLPC_P60 PF00877.19 AET41468.1 - 0.18 11.9 0.5 0.48 10.5 0.0 1.9 2 0 0 2 2 2 0 NlpC/P60 family Scs3p PF10261.9 AET41469.1 - 1.1e-16 61.1 19.7 4.2e-11 42.8 4.0 2.5 1 1 1 2 2 2 2 Inositol phospholipid synthesis and fat-storage-inducing TM PAP2 PF01569.21 AET41469.1 - 0.064 13.0 4.3 0.14 12.0 4.3 1.7 1 0 0 1 1 1 0 PAP2 superfamily DUF2721 PF11026.8 AET41469.1 - 0.19 11.6 4.1 0.23 11.4 2.4 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2721) S_4TM PF18159.1 AET41469.1 - 0.22 10.8 3.5 0.43 9.8 3.5 1.4 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain CENP-O PF09496.10 AET41470.1 - 3.4e-14 53.3 0.1 1.2e-13 51.6 0.1 1.8 1 1 0 1 1 1 1 Cenp-O kinetochore centromere component HIM1 PF08732.10 AET41471.1 - 9.5e-57 191.2 1.3 1.1e-56 191.0 0.0 1.7 2 0 0 2 2 2 1 HIM1 REPA_OB_2 PF16900.5 AET41471.1 - 0.04 13.8 0.0 0.13 12.2 0.0 1.8 1 0 0 1 1 1 0 Replication protein A OB domain NDT80_PhoG PF05224.12 AET41472.1 - 3.8e-67 226.1 0.7 3.8e-67 226.1 0.7 2.5 2 0 0 2 2 2 1 NDT80 / PhoG like DNA-binding family PBP1_TM PF14812.6 AET41472.1 - 1.3 9.5 5.8 4.2 7.8 5.8 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DTHCT PF08070.11 AET41472.1 - 7 7.4 10.5 0.3 11.8 3.0 2.5 2 0 0 2 2 2 0 DTHCT (NUC029) region GNAT_acetyltr_2 PF13718.6 AET41473.1 - 3.6e-98 327.5 0.3 1.1e-97 325.9 0.0 2.1 2 0 0 2 2 2 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 AET41473.1 - 3.1e-85 285.6 4.4 7.1e-85 284.4 4.4 1.6 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 AET41473.1 - 3.9e-66 222.3 0.2 2.6e-65 219.6 0.0 2.4 2 1 0 2 2 2 1 Helicase DUF1726 PF08351.11 AET41473.1 - 2.9e-33 113.7 0.8 1.1e-32 111.8 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) AAA_22 PF13401.6 AET41473.1 - 0.0015 18.8 0.0 0.26 11.5 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 AET41473.1 - 0.0029 17.4 0.0 0.099 12.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 AET41473.1 - 0.0049 16.7 0.3 0.012 15.4 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_19 PF13245.6 AET41473.1 - 0.028 14.7 0.0 0.13 12.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain FumaraseC_C PF10415.9 AET41473.1 - 0.05 14.0 0.0 13 6.3 0.0 2.8 2 0 0 2 2 2 0 Fumarase C C-terminus DUF2443 PF10398.9 AET41473.1 - 1.7 8.8 3.9 4.5 7.4 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2443) Tom22 PF04281.13 AET41474.1 - 1e-45 154.9 0.7 1.2e-45 154.7 0.7 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 CDP-OH_P_transf PF01066.21 AET41475.1 - 5.2e-15 56.0 0.1 5.2e-15 56.0 0.1 3.6 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase FeS_assembly_P PF01883.19 AET41476.1 - 6.1e-07 29.5 0.0 1.2e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein Smoothelin PF12510.8 AET41476.1 - 0.012 15.6 1.3 0.029 14.4 0.3 2.2 2 0 0 2 2 2 0 Smoothelin cytoskeleton protein AAA_18 PF13238.6 AET41477.1 - 0.0014 19.2 0.1 0.012 16.2 0.1 2.1 1 1 0 1 1 1 1 AAA domain PRK PF00485.18 AET41477.1 - 0.046 13.4 0.4 0.14 11.9 0.4 1.8 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family DUF4988 PF16378.5 AET41477.1 - 0.084 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DSPc PF00782.20 AET41478.1 - 3.2e-10 40.0 0.0 8e-10 38.7 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PRP8_domainIV PF12134.8 AET41478.1 - 0.017 14.8 0.0 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 PRP8 domain IV core Y_phosphatase PF00102.27 AET41478.1 - 0.019 14.5 0.0 0.042 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 AET41478.1 - 0.035 14.2 0.0 0.07 13.2 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 AET41478.1 - 0.044 13.7 0.0 0.074 13.0 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family AD PF09793.9 AET41479.1 - 3.8e-23 81.4 0.2 5.5e-23 80.9 0.2 1.2 1 0 0 1 1 1 1 Anticodon-binding domain N1221 PF07923.13 AET41480.1 - 2e-66 224.1 1.4 2e-66 224.1 1.4 1.5 2 0 0 2 2 2 1 N1221-like protein DUF3402 PF11882.8 AET41480.1 - 2.3e-56 191.8 16.1 4.4e-22 78.8 0.2 3.5 2 1 2 4 4 4 3 Domain of unknown function (DUF3402) GCP_C_terminal PF04130.13 AET41481.1 - 2.2e-37 129.2 7.6 2.2e-37 129.2 7.6 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 AET41481.1 - 4.3e-31 108.7 11.8 4.4e-31 108.6 3.7 2.4 2 0 0 2 2 2 2 Gamma tubulin complex component N-terminal IL11 PF07400.11 AET41481.1 - 0.0015 18.3 1.8 0.014 15.0 0.1 2.8 2 0 0 2 2 2 1 Interleukin 11 Cas_VVA1548 PF09652.10 AET41481.1 - 0.056 13.7 0.0 0.19 12.0 0.0 1.9 1 0 0 1 1 1 0 Putative CRISPR-associated protein (Cas_VVA1548) Gar1 PF04410.14 AET41482.1 - 3e-42 144.0 1.1 3e-42 144.0 1.1 3.1 4 1 0 4 4 4 1 Gar1/Naf1 RNA binding region SMYLE_N PF18615.1 AET41482.1 - 0.053 13.1 0.2 0.053 13.1 0.2 3.4 3 1 1 4 4 4 0 Short myomegalin-like EB1 binding proteins, N-terminal domain T2SSC PF11356.8 AET41482.1 - 3.1 7.7 8.6 14 5.6 8.6 2.1 1 0 0 1 1 1 0 Type II secretion system protein C MutS_V PF00488.21 AET41483.1 - 5.2e-69 232.0 0.0 1e-68 231.1 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 AET41483.1 - 2.6e-32 112.6 4.1 5.8e-32 111.5 4.1 1.6 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 AET41483.1 - 1.8e-27 95.8 0.1 5.3e-27 94.3 0.1 1.9 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 AET41483.1 - 2e-08 34.6 0.3 9.3e-08 32.4 0.0 2.3 2 0 0 2 2 2 1 MutS domain II AAA_14 PF13173.6 AET41483.1 - 0.0057 16.7 0.6 0.28 11.2 0.0 3.5 4 0 0 4 4 4 1 AAA domain Vault PF01505.18 AET41483.1 - 0.19 11.9 0.0 0.92 9.7 0.0 2.1 2 0 0 2 2 2 0 Major Vault Protein repeat domain AAA_23 PF13476.6 AET41483.1 - 0.34 11.4 0.0 0.34 11.4 0.0 3.8 2 1 0 2 2 2 0 AAA domain N-SET PF11764.8 AET41484.1 - 4.8e-51 173.3 5.2 4.8e-51 173.3 5.2 2.4 3 0 0 3 3 3 1 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.8 AET41484.1 - 2.6e-19 68.6 0.1 7.2e-19 67.2 0.1 1.7 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated SET PF00856.28 AET41484.1 - 8.9e-19 68.5 0.1 8.9e-19 68.5 0.1 2.8 2 1 0 2 2 2 1 SET domain CENP-X PF09415.10 AET41484.1 - 0.062 13.6 0.1 0.72 10.2 0.0 2.6 2 0 0 2 2 2 0 CENP-S associating Centromere protein X ORC6 PF05460.13 AET41485.1 - 1.7e-99 333.5 0.8 2.1e-99 333.2 0.8 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) PDZ_1 PF12812.7 AET41486.1 - 7.7e-54 179.6 0.0 5.9e-37 125.5 0.0 3.0 2 0 0 2 2 2 2 PDZ-like domain Trypsin_2 PF13365.6 AET41486.1 - 1.5e-23 84.4 0.4 9.7e-20 72.0 0.0 2.6 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ PF00595.24 AET41486.1 - 1.7e-11 44.3 0.2 8.5e-07 29.2 0.0 3.8 4 0 0 4 4 4 2 PDZ domain PDZ_6 PF17820.1 AET41486.1 - 2.8e-11 43.1 3.4 5.9e-08 32.4 0.1 3.5 5 0 0 5 5 5 2 PDZ domain PDZ_2 PF13180.6 AET41486.1 - 5.9e-11 42.5 0.2 0.00018 21.8 0.0 3.9 3 0 0 3 3 3 2 PDZ domain Trypsin PF00089.26 AET41486.1 - 0.00024 21.0 0.0 0.0021 17.9 0.0 2.4 2 0 0 2 2 2 1 Trypsin Tricorn_PDZ PF14685.6 AET41486.1 - 0.00049 20.0 0.8 0.16 11.9 0.1 3.2 3 0 0 3 3 3 1 Tricorn protease PDZ domain DUF31 PF01732.16 AET41486.1 - 0.014 15.0 0.2 0.023 14.2 0.2 1.3 1 0 0 1 1 1 0 Putative peptidase (DUF31) Rad9_Rad53_bind PF08605.10 AET41486.1 - 0.12 12.5 0.1 0.5 10.6 0.0 2.1 2 0 0 2 2 2 0 Fungal Rad9-like Rad53-binding Peptidase_S7 PF00949.21 AET41486.1 - 0.14 11.9 0.1 0.38 10.6 0.1 1.6 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Peptidase_S46 PF10459.9 AET41486.1 - 0.23 10.1 0.0 0.39 9.3 0.0 1.3 1 0 0 1 1 1 0 Peptidase S46 Ribosomal_L35p PF01632.19 AET41487.1 - 7e-14 52.1 6.2 9.2e-14 51.7 6.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L35 TPR_2 PF07719.17 AET41489.1 - 7.3e-25 85.0 31.5 0.0014 18.6 0.0 11.5 11 1 1 12 12 11 6 Tetratricopeptide repeat TPR_1 PF00515.28 AET41489.1 - 2.6e-24 84.0 29.9 1.9e-06 27.4 0.5 11.2 10 1 1 11 11 11 4 Tetratricopeptide repeat TPR_16 PF13432.6 AET41489.1 - 9.9e-21 74.1 3.6 5.5e-05 23.7 0.7 6.4 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 AET41489.1 - 2.8e-16 59.8 20.4 1.1e-07 32.3 3.2 7.7 7 1 1 8 8 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 AET41489.1 - 1.5e-15 56.5 16.4 0.00067 20.3 0.1 8.9 6 3 4 10 10 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 AET41489.1 - 7.9e-15 54.9 18.0 0.0072 16.6 0.7 8.2 6 2 1 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 AET41489.1 - 1.7e-12 46.5 30.3 0.13 12.6 0.1 9.7 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_11 PF13414.6 AET41489.1 - 2e-12 46.6 16.3 0.004 16.8 0.1 7.7 6 2 2 8 8 8 3 TPR repeat TPR_17 PF13431.6 AET41489.1 - 4.7e-11 42.3 10.6 0.02 15.2 0.0 7.5 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 AET41489.1 - 1.4e-06 28.3 0.2 1.2 9.4 0.0 5.4 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_MalT PF17874.1 AET41489.1 - 1.4e-06 27.9 2.6 6.6e-05 22.4 1.7 2.5 1 1 0 2 2 2 1 MalT-like TPR region TPR_6 PF13174.6 AET41489.1 - 2.1e-06 28.0 17.7 0.57 10.9 0.2 8.9 8 0 0 8 8 8 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AET41489.1 - 4e-06 26.9 15.2 0.0014 18.8 0.2 5.3 4 1 3 7 7 6 3 Anaphase-promoting complex, cyclosome, subunit 3 HrpB1_HrpK PF09613.10 AET41489.1 - 6.2e-06 25.9 0.0 0.063 12.9 0.2 3.1 2 1 1 3 3 3 2 Bacterial type III secretion protein (HrpB1_HrpK) TPR_21 PF09976.9 AET41489.1 - 0.0039 16.9 14.6 0.032 14.0 1.3 4.7 3 1 1 5 5 5 2 Tetratricopeptide repeat-like domain NARP1 PF12569.8 AET41489.1 - 0.0061 15.5 0.1 0.0061 15.5 0.1 3.8 3 1 1 5 5 5 1 NMDA receptor-regulated protein 1 TPR_7 PF13176.6 AET41489.1 - 0.0095 15.9 10.5 6.9 6.9 0.2 6.2 6 0 0 6 6 5 0 Tetratricopeptide repeat PknG_TPR PF16918.5 AET41489.1 - 0.016 13.9 0.2 0.86 8.3 0.2 2.2 1 1 0 1 1 1 0 Protein kinase G tetratricopeptide repeat Exonuc_VII_S PF02609.16 AET41489.1 - 0.023 14.7 1.1 0.023 14.7 1.1 3.9 4 0 0 4 4 4 0 Exonuclease VII small subunit DUF5113 PF17140.4 AET41489.1 - 0.034 13.9 0.9 5.5 6.8 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5113) TPR_20 PF14561.6 AET41489.1 - 0.12 12.7 8.9 0.09 13.1 2.2 3.9 4 1 0 4 4 4 0 Tetratricopeptide repeat PPR_2 PF13041.6 AET41489.1 - 0.13 12.4 3.7 33 4.8 0.0 4.9 6 0 0 6 6 5 0 PPR repeat family SPO22 PF08631.10 AET41489.1 - 0.28 10.6 6.7 2.4 7.6 0.4 3.5 3 1 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like TPR_3 PF07720.12 AET41489.1 - 0.32 11.0 8.9 0.46 10.5 0.2 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 AET41489.1 - 1 9.3 13.0 6.5 6.8 0.3 5.6 6 0 0 6 6 5 0 Tetratricopeptide repeat ANAPC5 PF12862.7 AET41489.1 - 1.5 8.9 6.1 3.4 7.8 0.4 3.4 2 2 1 3 3 3 0 Anaphase-promoting complex subunit 5 YfdX PF10938.8 AET41489.1 - 5.8 6.8 9.1 1.2 9.1 3.0 3.0 4 0 0 4 4 2 0 YfdX protein CHCH PF06747.13 AET41490.1 - 4e-07 30.0 7.5 5.7e-07 29.5 7.5 1.3 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.10 AET41490.1 - 0.00024 21.3 2.2 0.00037 20.7 2.2 1.3 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type Pet191_N PF10203.9 AET41490.1 - 0.062 13.6 2.5 0.097 13.0 2.5 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 PASTA PF03793.19 AET41490.1 - 0.15 11.9 0.5 0.25 11.2 0.5 1.3 1 0 0 1 1 1 0 PASTA domain CTU2 PF10288.9 AET41491.1 - 4.6e-22 78.4 0.1 9.4e-22 77.4 0.1 1.6 1 0 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 zinc_ribbon_9 PF14369.6 AET41491.1 - 5.6 7.3 7.8 3.1 8.1 4.0 2.5 2 0 0 2 2 2 0 zinc-ribbon DCP2 PF05026.13 AET41492.1 - 3.4e-24 85.0 0.6 8.8e-24 83.6 0.6 1.8 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 AET41492.1 - 3.1e-12 46.7 0.0 8.3e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 NUDIX domain TFIIA PF03153.13 AET41492.1 - 0.001 19.2 32.7 0.001 19.2 32.7 2.4 1 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit NOA36 PF06524.12 AET41492.1 - 2.7 7.3 9.4 5.1 6.3 9.4 1.4 1 0 0 1 1 1 0 NOA36 protein NMT1 PF09084.11 AET41493.1 - 1.6e-15 57.7 0.0 4.1e-15 56.3 0.0 1.7 1 1 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 AET41493.1 - 1.9e-09 37.6 0.0 3.6e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 NMT1-like family Phosphonate-bd PF12974.7 AET41493.1 - 5.6e-05 22.8 0.0 7.7e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 AET41493.1 - 0.00011 21.7 0.0 0.00023 20.7 0.0 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 LysR_substrate PF03466.20 AET41493.1 - 0.00011 21.6 0.0 0.0002 20.8 0.0 1.4 1 0 0 1 1 1 1 LysR substrate binding domain VTC PF09359.10 AET41494.1 - 4.3e-99 331.4 0.2 7.4e-99 330.6 0.2 1.4 1 0 0 1 1 1 1 VTC domain SPX PF03105.19 AET41494.1 - 1.5e-11 44.9 13.7 2.1e-05 24.6 2.2 3.8 3 1 1 4 4 4 3 SPX domain DUF202 PF02656.15 AET41494.1 - 8.3e-08 32.6 5.7 2.2e-07 31.2 5.7 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF202) Mad3_BUB1_I PF08311.12 AET41495.1 - 1.4e-42 144.5 1.1 3.7e-42 143.2 1.1 1.8 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_II PF08171.11 AET41495.1 - 3.8e-31 107.0 0.4 3.6e-29 100.7 0.1 2.9 2 0 0 2 2 2 1 Mad3/BUB1 homology region 2 Pkinase PF00069.25 AET41495.1 - 1.4e-18 67.2 0.0 2.5e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Mad3_BUB1_I_2 PF17014.5 AET41495.1 - 2.7e-05 24.3 0.9 7.5e-05 22.9 0.1 2.1 2 0 0 2 2 2 1 Putative Mad3/BUB1 like region 1 protein Pkinase_Tyr PF07714.17 AET41495.1 - 0.0012 18.2 0.0 0.0024 17.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET41495.1 - 0.04 13.2 0.0 0.074 12.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like UPF0180 PF03698.13 AET41495.1 - 0.058 13.6 0.1 0.57 10.4 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) Cpn60_TCP1 PF00118.24 AET41496.1 - 4.6e-162 540.1 2.1 5.3e-162 539.9 2.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Blt1_C PF17183.4 AET41498.1 - 0.0069 16.0 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 Get5 carboxyl domain Sad1_UNC PF07738.13 AET41499.1 - 5e-09 36.3 0.0 2.5e-08 34.0 0.0 2.1 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal DUF1664 PF07889.12 AET41499.1 - 0.0055 16.7 6.4 0.009 16.0 2.5 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 AET41499.1 - 0.01 15.8 2.0 0.01 15.8 2.0 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus LPP PF04728.13 AET41499.1 - 0.076 13.4 1.2 9.2 6.7 0.1 2.9 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Sds3 PF08598.11 AET41499.1 - 0.23 11.4 11.2 0.026 14.5 4.3 2.2 2 0 0 2 2 2 0 Sds3-like ABC_tran_CTD PF16326.5 AET41499.1 - 0.28 11.5 6.2 0.15 12.4 0.7 2.8 3 0 0 3 3 3 0 ABC transporter C-terminal domain SlyX PF04102.12 AET41499.1 - 2 9.1 6.0 2 9.1 0.3 3.1 3 0 0 3 3 3 0 SlyX YlqD PF11068.8 AET41499.1 - 3 8.2 13.0 4.8 7.6 6.5 2.6 2 0 0 2 2 2 0 YlqD protein Lzipper-MIP1 PF14389.6 AET41499.1 - 3.5 8.0 8.6 0.17 12.2 1.9 2.2 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 FapA PF03961.13 AET41499.1 - 4.2 5.9 7.3 0.33 9.5 2.7 1.4 2 0 0 2 2 2 0 Flagellar Assembly Protein A Bot1p PF12298.8 AET41500.1 - 2.7e-54 183.9 4.8 2.7e-54 183.9 4.8 1.5 2 0 0 2 2 2 1 Eukaryotic mitochondrial regulator protein DNA_pol3_alpha PF07733.12 AET41500.1 - 0.05 13.2 0.7 0.091 12.3 0.7 1.3 1 0 0 1 1 1 0 Bacterial DNA polymerase III alpha NTPase domain Actin_micro PF17003.5 AET41500.1 - 0.057 12.6 1.0 0.087 12.0 1.0 1.2 1 0 0 1 1 1 0 Putative actin-like family Trs65 PF12735.7 AET41501.1 - 8.4e-25 87.8 2.9 1.7e-12 47.4 0.2 2.2 1 1 1 2 2 2 2 TRAPP trafficking subunit Trs65 Clathrin_lg_ch PF01086.17 AET41502.1 - 1.9e-38 132.8 14.7 2.1e-38 132.7 14.7 1.0 1 0 0 1 1 1 1 Clathrin light chain Lsr2 PF11774.8 AET41502.1 - 0.045 13.9 2.2 0.045 13.9 2.2 1.7 1 1 0 1 1 1 0 Lsr2 Urm1 PF09138.11 AET41502.1 - 0.069 13.5 0.4 0.15 12.4 0.2 1.7 1 1 0 1 1 1 0 Urm1 (Ubiquitin related modifier) O-antigen_lig PF13425.6 AET41502.1 - 0.25 10.1 3.9 0.29 9.9 3.9 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein TMPIT PF07851.13 AET41502.1 - 0.97 8.6 3.2 1.2 8.4 3.2 1.0 1 0 0 1 1 1 0 TMPIT-like protein PBP_sp32 PF07222.12 AET41502.1 - 1.3 8.4 6.9 1.6 8.1 6.9 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 SH3_2 PF07653.17 AET41504.1 - 4.5e-07 29.5 2.2 7.3e-07 28.8 0.1 2.5 3 0 0 3 3 3 1 Variant SH3 domain SH3_1 PF00018.28 AET41504.1 - 5.8e-07 29.0 0.1 1.7e-06 27.5 0.1 1.9 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AET41504.1 - 0.0018 18.1 0.0 0.0038 17.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Ntox15 PF15604.6 AET41504.1 - 0.63 10.1 9.7 1.2 9.3 9.7 1.3 1 0 0 1 1 1 0 Novel toxin 15 DUF4519 PF15012.6 AET41504.1 - 1.6 9.0 3.8 3.9 7.7 3.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) PseudoU_synth_2 PF00849.22 AET41505.1 - 1.3e-29 103.3 0.0 2e-29 102.7 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase DUF3419 PF11899.8 AET41506.1 - 4.5e-146 486.9 0.0 5.8e-146 486.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_25 PF13649.6 AET41506.1 - 9.6e-13 48.7 0.0 1.8e-10 41.3 0.0 3.5 4 0 0 4 4 4 1 Methyltransferase domain Methyltransf_11 PF08241.12 AET41506.1 - 2.5e-11 44.1 0.0 2.7e-09 37.6 0.0 3.3 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 AET41506.1 - 7.6e-10 39.4 0.0 6.6e-08 33.2 0.0 3.0 3 0 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 AET41506.1 - 9e-10 38.3 0.0 1.6e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 AET41506.1 - 9e-10 38.6 0.0 2.9e-09 37.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AET41506.1 - 5e-07 29.6 0.0 8.4e-06 25.6 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 AET41506.1 - 0.0075 16.0 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_28 PF02636.17 AET41506.1 - 0.046 13.3 0.0 0.6 9.7 0.0 2.1 1 1 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase FSH1 PF03959.13 AET41508.1 - 1.5e-59 201.3 0.0 1.6e-59 201.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 AET41508.1 - 0.03 14.1 1.1 6.1 6.6 0.9 3.0 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase dCMP_cyt_deam_1 PF00383.23 AET41509.1 - 2.1e-22 78.9 0.5 3.1e-22 78.4 0.5 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 AET41509.1 - 2.4e-16 59.7 0.0 3.7e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase APOBEC_N PF08210.11 AET41509.1 - 0.0021 18.0 0.0 0.0033 17.3 0.0 1.3 1 0 0 1 1 1 1 APOBEC-like N-terminal domain SNAD4 PF18750.1 AET41509.1 - 0.0044 17.1 0.0 0.0085 16.2 0.0 1.4 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 Inv-AAD PF18785.1 AET41509.1 - 0.019 14.8 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase NAD1 PF18778.1 AET41509.1 - 0.026 14.6 0.0 0.054 13.6 0.0 1.5 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 Bd3614-deam PF14439.6 AET41509.1 - 0.041 14.0 0.7 0.16 12.0 0.1 1.9 1 1 1 2 2 2 0 Bd3614-like deaminase APOBEC2 PF18772.1 AET41509.1 - 0.059 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 APOBEC2 APOBEC3 PF18771.1 AET41509.1 - 0.06 13.5 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 APOBEC3 DUF5535 PF17687.1 AET41509.1 - 0.11 12.7 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5535) PX PF00787.24 AET41510.1 - 1.1e-23 83.4 0.1 3.4e-23 81.8 0.1 1.8 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 AET41510.1 - 3.6e-05 23.4 17.1 0.0029 17.2 8.6 2.4 1 1 0 2 2 2 2 Vps5 C terminal like DUF5129 PF17173.4 AET41510.1 - 0.047 12.8 1.0 0.081 12.0 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5129) Baculo_PEP_C PF04513.12 AET41510.1 - 0.056 13.5 0.9 0.4 10.7 0.0 2.4 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.12 AET41510.1 - 0.059 13.8 2.6 8 7.0 0.2 3.2 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein LPP PF04728.13 AET41510.1 - 0.11 12.9 2.7 1 9.8 0.2 3.6 3 1 0 3 3 3 0 Lipoprotein leucine-zipper Cytochrom_B562 PF07361.11 AET41510.1 - 0.44 11.2 7.1 2.1 9.0 0.0 3.9 2 2 2 4 4 4 0 Cytochrome b562 Laminin_II PF06009.12 AET41510.1 - 0.45 10.5 7.1 5.7 6.9 1.1 2.6 2 1 1 3 3 3 0 Laminin Domain II DASH_Dam1 PF08653.10 AET41510.1 - 0.61 9.9 2.5 19 5.1 0.0 3.9 4 0 0 4 4 4 0 DASH complex subunit Dam1 T3SSipB PF16535.5 AET41510.1 - 0.93 10.0 5.9 6 7.3 0.1 2.6 2 1 0 2 2 2 0 Type III cell invasion protein SipB bZIP_1 PF00170.21 AET41510.1 - 1.2 9.3 4.7 10 6.3 1.1 3.5 3 0 0 3 3 3 0 bZIP transcription factor FlaC_arch PF05377.11 AET41510.1 - 1.7 9.1 7.7 14 6.1 0.1 4.0 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) Ax_dynein_light PF10211.9 AET41510.1 - 2.3 8.1 11.3 5.1 7.0 5.7 2.5 2 1 0 2 2 2 0 Axonemal dynein light chain APG6_N PF17675.1 AET41510.1 - 2.6 8.6 15.8 1.6 9.3 0.8 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region ZYG-11_interact PF05884.12 AET41510.1 - 3.4 7.0 5.8 15 4.8 0.0 3.1 2 1 1 3 3 3 0 Interactor of ZYG-11 LOH1CR12 PF10158.9 AET41510.1 - 8.3 6.5 10.4 6.3 6.8 0.3 3.6 3 1 1 4 4 4 0 Tumour suppressor protein DPPIV_N PF00930.21 AET41511.1 - 8.9e-97 324.0 3.3 1.2e-96 323.6 3.3 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 AET41511.1 - 3.2e-54 183.6 0.9 5.4e-54 182.9 0.9 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 AET41511.1 - 0.00068 20.3 0.0 0.069 13.8 0.0 2.8 2 1 1 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 AET41511.1 - 0.054 13.3 0.5 3.3 7.5 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase COesterase PF00135.28 AET41511.1 - 0.075 11.9 0.1 0.14 11.0 0.1 1.3 1 0 0 1 1 1 0 Carboxylesterase family PAF-AH_p_II PF03403.13 AET41511.1 - 0.14 10.6 0.0 0.25 9.8 0.0 1.3 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II RPN1_RPN2_N PF17781.1 AET41512.1 - 6.7e-115 383.7 0.9 1.3e-114 382.8 0.9 1.5 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 AET41512.1 - 1.3e-28 98.8 0.1 2.3e-28 98.0 0.1 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 AET41512.1 - 1.4e-26 91.5 15.2 1.5e-07 31.5 0.3 8.5 8 0 0 8 8 8 6 Proteasome/cyclosome repeat ATP-synt_C PF00137.21 AET41513.1 - 3.9e-23 81.6 38.9 5e-16 58.8 11.1 2.6 3 0 0 3 3 3 2 ATP synthase subunit C GHMP_kinases_N PF00288.26 AET41514.1 - 2.6e-09 37.2 0.0 5.4e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 AET41514.1 - 4.1e-05 23.9 0.0 0.00011 22.5 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal Peptidase_M16_C PF05193.21 AET41515.1 - 2.8e-40 138.3 0.1 1.1e-39 136.4 0.0 2.0 2 1 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 AET41515.1 - 1.7e-34 118.9 0.5 2.2e-33 115.3 0.0 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) AAA_lid_2 PF17863.1 AET41515.1 - 0.04 13.7 0.0 0.086 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA lid domain Myosin_head PF00063.21 AET41516.1 - 3.7e-263 874.8 16.8 3.7e-263 874.8 16.8 3.1 2 0 0 2 2 2 1 Myosin head (motor domain) ERM PF00769.19 AET41516.1 - 0.00025 21.0 30.8 0.00025 21.0 30.8 7.8 2 1 4 7 7 7 1 Ezrin/radixin/moesin family Sigma54_activat PF00158.26 AET41516.1 - 0.00053 19.7 0.0 0.0019 18.0 0.0 1.9 1 0 0 1 1 1 1 Sigma-54 interaction domain Myosin_N PF02736.19 AET41516.1 - 0.007 16.2 0.8 0.031 14.1 0.8 2.2 1 1 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_16 PF13191.6 AET41516.1 - 0.12 12.8 0.0 0.12 12.8 0.0 4.0 4 2 0 4 4 4 0 AAA ATPase domain AAA_22 PF13401.6 AET41516.1 - 0.2 11.9 0.0 0.2 11.9 0.0 4.1 3 0 0 3 3 3 0 AAA domain F-box-like PF12937.7 AET41517.1 - 1.5e-07 31.2 0.2 5.6e-07 29.4 0.0 2.1 2 0 0 2 2 2 1 F-box-like F-box_4 PF15966.5 AET41517.1 - 7.3e-05 22.6 0.0 0.00021 21.1 0.0 1.8 1 0 0 1 1 1 1 F-box F-box PF00646.33 AET41517.1 - 0.00026 20.8 0.0 0.001 18.9 0.0 2.0 1 0 0 1 1 1 1 F-box domain PRANC PF09372.10 AET41517.1 - 0.023 15.0 0.3 0.1 13.0 0.0 2.2 3 0 0 3 3 3 0 PRANC domain LRR_4 PF12799.7 AET41517.1 - 1.6 9.3 10.9 1.8 9.1 0.0 4.8 5 2 1 6 6 6 0 Leucine Rich repeats (2 copies) Ras PF00071.22 AET41518.1 - 1.5e-23 83.2 0.1 8.6e-18 64.5 0.1 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 AET41518.1 - 3e-07 30.7 0.0 0.004 17.4 0.0 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AET41518.1 - 0.0078 15.7 0.0 4.3 6.7 0.0 2.5 2 1 1 3 3 3 2 ADP-ribosylation factor family SRPRB PF09439.10 AET41518.1 - 0.013 14.9 0.3 0.22 10.9 0.0 2.7 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 AET41518.1 - 0.034 13.7 0.1 0.32 10.5 0.1 2.3 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain MobB PF03205.14 AET41518.1 - 0.16 11.8 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Ribosomal_S27e PF01667.17 AET41519.1 - 3e-30 103.7 2.8 4e-30 103.3 2.8 1.2 1 0 0 1 1 1 1 Ribosomal protein S27 IBR PF01485.21 AET41519.1 - 0.0026 17.9 1.0 0.0032 17.7 1.0 1.2 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain TF_Zn_Ribbon PF08271.12 AET41519.1 - 0.024 14.1 4.2 0.035 13.6 4.2 1.2 1 0 0 1 1 1 0 TFIIB zinc-binding zf-ACC PF17848.1 AET41519.1 - 3.2 7.9 6.4 19 5.4 0.2 2.3 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Rsm22 PF09243.10 AET41520.1 - 4.1e-30 105.0 0.3 6.6e-14 51.8 0.7 3.8 2 2 0 2 2 2 2 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.6 AET41520.1 - 0.0025 17.7 0.0 0.0088 15.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain SRPRB PF09439.10 AET41521.1 - 1.8e-62 210.0 0.0 2.3e-62 209.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 AET41521.1 - 6.1e-08 32.3 0.0 7.8e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AET41521.1 - 9.1e-07 28.5 0.0 1.2e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AET41521.1 - 3.4e-06 27.1 0.0 5.4e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_21 PF13304.6 AET41521.1 - 0.03 14.1 0.2 0.058 13.2 0.2 1.6 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Roc PF08477.13 AET41521.1 - 0.13 12.5 0.0 0.22 11.8 0.0 1.6 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 AET41521.1 - 0.4 10.4 1.6 0.8 9.5 0.1 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain DPM2 PF07297.12 AET41522.1 - 2.3e-12 47.1 4.3 2.6e-12 46.8 4.3 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF4229 PF14012.6 AET41522.1 - 0.052 13.7 5.3 0.18 11.9 5.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4229) LapA_dom PF06305.11 AET41522.1 - 0.2 11.5 2.4 0.37 10.6 2.4 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Nup192 PF11894.8 AET41523.1 - 0 1730.7 56.7 0 1730.5 56.7 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 DUF1344 PF07076.11 AET41523.1 - 0.01 15.7 0.1 0.038 13.9 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) Nsp1_C PF05064.13 AET41524.1 - 1.5e-41 140.9 6.4 1.5e-41 140.9 6.4 2.2 1 1 1 2 2 2 1 Nsp1-like C-terminal region NAM-associated PF14303.6 AET41524.1 - 0.0038 18.0 0.0 0.071 13.8 0.0 2.9 2 1 0 2 2 2 1 No apical meristem-associated C-terminal domain DNA_primase_lrg PF04104.14 AET41524.1 - 0.17 11.2 1.6 0.28 10.5 1.1 1.5 1 1 0 1 1 1 0 Eukaryotic and archaeal DNA primase, large subunit Caudo_TAP PF02413.17 AET41524.1 - 0.2 11.8 3.3 0.8 9.9 2.2 2.4 2 1 0 2 2 2 0 Caudovirales tail fibre assembly protein, lambda gpK FAM76 PF16046.5 AET41524.1 - 0.93 8.8 13.1 0.017 14.5 1.9 2.2 1 1 1 2 2 2 0 FAM76 protein LRR_4 PF12799.7 AET41525.1 - 0.024 15.1 14.7 2.1 8.9 2.9 5.9 6 1 2 8 8 8 0 Leucine Rich repeats (2 copies) ImcF-related_N PF14331.6 AET41525.1 - 0.16 11.3 0.8 0.28 10.5 0.2 1.7 2 0 0 2 2 2 0 ImcF-related N-terminal domain LRR_1 PF00560.33 AET41525.1 - 4.1 8.3 4.8 17 6.4 1.6 3.9 2 2 0 2 2 2 0 Leucine Rich Repeat RabGAP-TBC PF00566.18 AET41527.1 - 2.8e-18 66.4 4.1 3.4e-18 66.1 3.1 1.6 1 1 1 2 2 2 1 Rab-GTPase-TBC domain His_Phos_1 PF00300.22 AET41528.1 - 1.1e-35 123.1 0.0 4.6e-29 101.5 0.1 2.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Tnp_22_dsRBD PF17490.2 AET41528.1 - 0.15 12.0 0.0 0.38 10.8 0.0 1.6 1 0 0 1 1 1 0 L1 transposable element dsRBD-like domain Carb_kinase PF01256.17 AET41529.1 - 1.1e-52 179.0 0.1 1.4e-52 178.6 0.1 1.1 1 0 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.12 AET41529.1 - 0.00016 21.1 0.4 0.0019 17.6 0.0 2.3 2 1 0 2 2 2 1 Phosphomethylpyrimidine kinase NAD_binding_1 PF00175.21 AET41530.1 - 1e-28 100.1 0.0 1.7e-28 99.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 AET41530.1 - 7.3e-26 90.4 0.0 1.2e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 AET41530.1 - 2.5e-06 27.7 0.0 0.00095 19.3 0.0 2.4 1 1 1 2 2 2 2 Ferric reductase NAD binding domain SLT_L PF14718.6 AET41530.1 - 0.0093 16.1 1.3 0.025 14.7 1.2 1.8 1 1 1 2 2 2 1 Soluble lytic murein transglycosylase L domain FAD_binding_2 PF00890.24 AET41531.1 - 4e-122 408.3 4.3 5.2e-122 407.9 4.3 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 AET41531.1 - 6.8e-43 145.7 0.1 1.1e-42 145.1 0.1 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.22 AET41531.1 - 8.1e-06 25.2 0.6 0.00076 18.7 0.4 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.17 AET41531.1 - 5.5e-05 22.5 0.1 0.0041 16.4 0.0 2.5 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 AET41531.1 - 8.8e-05 21.9 0.1 0.00033 20.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 AET41531.1 - 0.0024 17.2 0.3 0.0057 15.9 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 AET41531.1 - 0.054 13.1 4.4 0.42 10.1 4.3 2.1 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 AET41531.1 - 0.08 11.6 1.2 0.2 10.4 0.3 2.0 3 0 0 3 3 3 0 HI0933-like protein Aa_trans PF01490.18 AET41532.1 - 2.4e-90 303.2 28.8 2.9e-90 302.9 28.8 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AAA PF00004.29 AET41533.1 - 2.7e-40 137.8 0.0 6.1e-40 136.7 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AET41533.1 - 4.2e-07 29.7 0.0 1.2e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 AET41533.1 - 6.2e-05 23.0 0.0 0.00021 21.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AET41533.1 - 6.4e-05 23.3 0.0 0.0029 17.9 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 AET41533.1 - 0.00017 22.0 0.1 0.0035 17.7 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 AET41533.1 - 0.00039 20.6 0.0 0.00079 19.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 AET41533.1 - 0.0008 18.6 0.0 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 AET41533.1 - 0.0048 16.7 0.0 0.0089 15.8 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 AET41533.1 - 0.013 15.8 0.0 0.022 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 AET41533.1 - 0.023 14.9 0.0 0.055 13.6 0.0 1.7 2 0 0 2 2 1 0 AAA domain ATPase_2 PF01637.18 AET41533.1 - 0.032 14.2 0.7 5.6 6.8 0.0 2.8 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 AET41533.1 - 0.032 14.8 0.0 0.077 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 AET41533.1 - 0.036 13.8 0.2 0.087 12.5 0.1 1.8 2 1 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 AET41533.1 - 0.038 14.4 0.0 0.085 13.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 AET41533.1 - 0.041 13.4 0.0 0.098 12.2 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 AET41533.1 - 0.043 13.2 0.0 0.11 11.8 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 AET41533.1 - 0.05 13.5 0.0 0.09 12.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 AET41533.1 - 0.057 12.6 0.0 0.097 11.9 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain IstB_IS21 PF01695.17 AET41533.1 - 0.098 12.4 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_pol_Rbc25 PF08292.12 AET41534.1 - 4.6e-49 165.9 0.1 6.1e-49 165.5 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 AET41534.1 - 5.9e-20 71.4 0.0 2e-19 69.7 0.0 1.9 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 AET41534.1 - 0.074 13.4 0.0 0.2 12.0 0.0 1.7 1 1 0 1 1 1 0 S1 RNA binding domain LTV PF04180.14 AET41535.1 - 1.2e-112 377.4 25.0 1.4e-112 377.2 25.0 1.0 1 0 0 1 1 1 1 Low temperature viability protein DUF3294 PF07957.11 AET41536.1 - 1.7e-91 305.8 1.4 1.9e-91 305.6 1.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3294) CCDC32 PF14989.6 AET41536.1 - 0.0075 16.3 1.0 0.016 15.2 0.1 1.9 2 0 0 2 2 2 1 Coiled-coil domain containing 32 Snf7 PF03357.21 AET41536.1 - 0.047 13.3 0.5 0.047 13.3 0.5 2.2 2 0 0 2 2 2 0 Snf7 DUF1367 PF07105.11 AET41536.1 - 0.068 12.8 0.1 0.16 11.6 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1367) PUF PF00806.19 AET41537.1 - 1.6e-31 106.2 11.0 0.00036 20.0 0.0 8.9 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat Cpn60_TCP1 PF00118.24 AET41538.1 - 7.1e-151 503.2 5.5 8.1e-151 503.0 5.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Nitro_FeMo-Co PF02579.17 AET41538.1 - 0.0049 17.2 0.1 0.39 11.1 0.0 2.9 2 0 0 2 2 2 1 Dinitrogenase iron-molybdenum cofactor Vps53_N PF04100.12 AET41539.1 - 3e-85 286.5 9.3 3e-85 286.5 9.3 2.1 2 0 0 2 2 2 1 Vps53-like, N-terminal VPS53_C PF16854.5 AET41539.1 - 2e-72 243.4 2.9 2.6e-72 243.0 1.0 2.2 2 0 0 2 2 2 1 Vacuolar protein sorting-associated protein 53 C-terminus Glypican PF01153.19 AET41539.1 - 0.029 13.2 0.2 0.072 11.9 0.1 1.6 2 0 0 2 2 2 0 Glypican DUF3724 PF12521.8 AET41539.1 - 0.18 11.8 0.1 0.4 10.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3724) ArdA PF07275.11 AET41539.1 - 2.6 8.6 6.2 20 5.7 0.0 3.4 3 2 1 4 4 4 0 Antirestriction protein (ArdA) Baculo_PEP_C PF04513.12 AET41539.1 - 3.6 7.6 7.3 7 6.7 0.7 3.1 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HORMA PF02301.18 AET41540.1 - 1.7e-25 89.9 0.1 2.4e-25 89.4 0.1 1.2 1 0 0 1 1 1 1 HORMA domain ATG13 PF10033.9 AET41540.1 - 0.0011 18.8 0.0 0.0024 17.6 0.0 1.5 1 1 0 1 1 1 1 Autophagy-related protein 13 bacHORMA_2 PF18173.1 AET41540.1 - 0.0038 17.1 0.2 0.3 10.9 0.1 2.2 2 0 0 2 2 2 2 Bacterial HORMA domain 2 ATG101 PF07855.12 AET41540.1 - 0.0053 16.7 1.2 0.086 12.8 1.2 2.1 1 1 0 1 1 1 1 Autophagy-related protein 101 V-set_CD47 PF08204.11 AET41540.1 - 0.012 15.6 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain PPTA PF01239.22 AET41541.1 - 2.6e-34 116.0 17.0 1.8e-08 33.9 1.3 6.0 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat SYCP2_ARLD PF18581.1 AET41541.1 - 0.016 15.2 0.6 0.024 14.6 0.6 1.3 1 0 0 1 1 1 0 Synaptonemal complex 2 armadillo-repeat-like domain Phage_TAC_5 PF08890.11 AET41541.1 - 0.048 13.7 0.0 0.5 10.4 0.0 2.4 1 1 1 2 2 2 0 Phage XkdN-like tail assembly chaperone protein, TAC Cyclin_N PF00134.23 AET41542.1 - 6.9e-14 51.7 2.8 6.9e-14 51.7 2.8 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Endonuc-MspI PF09208.10 AET41542.1 - 0.044 13.2 0.6 0.17 11.3 0.0 1.9 2 0 0 2 2 2 0 Restriction endonuclease MspI DEAD PF00270.29 AET41543.1 - 5.6e-47 159.8 0.0 1.7e-46 158.2 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET41543.1 - 2.2e-24 85.9 0.0 1e-23 83.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 AET41543.1 - 2e-21 76.0 0.0 4.3e-21 74.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 AET41543.1 - 4.7e-08 33.2 0.1 2.1e-07 31.1 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit FHA PF00498.26 AET41544.1 - 7.5e-16 58.2 0.0 2.3e-14 53.5 0.0 2.2 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 AET41544.1 - 0.0099 16.2 0.0 0.23 11.8 0.0 2.4 3 0 0 3 3 3 1 Inner membrane component of T3SS, cytoplasmic domain HSP70 PF00012.20 AET41545.1 - 6.2e-260 863.5 10.8 7.1e-260 863.3 10.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AET41545.1 - 2.9e-18 65.8 1.4 7e-17 61.2 0.2 2.1 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 AET41545.1 - 0.0013 19.1 3.9 0.98 9.9 0.2 3.7 3 2 0 3 3 3 2 Cell division protein FtsA Radial_spoke_3 PF06098.11 AET41545.1 - 0.0034 16.7 3.4 0.007 15.7 3.4 1.4 1 0 0 1 1 1 1 Radial spoke protein 3 Hydantoinase_A PF01968.18 AET41545.1 - 0.013 14.8 0.7 0.33 10.2 0.0 2.6 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase Nramp PF01566.18 AET41546.1 - 1.8e-91 306.8 17.0 2.9e-91 306.1 17.0 1.3 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Mpv17_PMP22 PF04117.12 AET41546.1 - 0.72 10.1 5.0 0.69 10.2 0.7 2.6 2 0 0 2 2 2 0 Mpv17 / PMP22 family HEAT_EZ PF13513.6 AET41547.1 - 0.2 12.2 0.1 2.6 8.6 0.1 2.5 2 0 0 2 2 2 0 HEAT-like repeat RNase_PH PF01138.21 AET41548.1 - 2.2e-28 99.4 0.0 3e-28 99.0 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AET41548.1 - 4.8e-07 29.7 0.2 2.3e-06 27.5 0.1 2.1 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 DHQS PF01959.16 AET41548.1 - 0.0081 15.1 0.0 0.011 14.6 0.0 1.2 1 0 0 1 1 1 1 3-dehydroquinate synthase II Mannosyl_trans PF05007.13 AET41549.1 - 4.6e-78 262.7 30.0 4.6e-78 262.7 30.0 1.7 2 0 0 2 2 2 1 Mannosyltransferase (PIG-M) GT87 PF09594.10 AET41549.1 - 2e-08 34.2 9.9 2e-08 34.2 9.9 2.0 1 1 1 2 2 2 1 Glycosyltransferase family 87 PIG-U PF06728.13 AET41549.1 - 0.00012 21.3 30.3 0.00081 18.6 30.3 2.0 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U DUF5572 PF17733.1 AET41550.1 - 2.8e-10 39.9 0.1 4.2e-10 39.3 0.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5572) NOC3p PF07540.11 AET41552.1 - 5.7e-27 94.0 0.7 5.7e-27 94.0 0.7 3.0 3 1 0 3 3 3 1 Nucleolar complex-associated protein CBF PF03914.17 AET41552.1 - 2.1e-25 89.7 0.3 2.1e-25 89.7 0.3 2.2 2 0 0 2 2 2 1 CBF/Mak21 family DUF1943 PF09172.11 AET41552.1 - 0.33 10.1 3.4 0.14 11.4 0.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) Mpp10 PF04006.12 AET41553.1 - 7.3e-141 470.6 63.7 8.9e-141 470.3 63.7 1.0 1 0 0 1 1 1 1 Mpp10 protein Peptidase_C13 PF01650.18 AET41553.1 - 0.0014 18.2 0.1 0.0027 17.3 0.1 1.5 1 0 0 1 1 1 1 Peptidase C13 family Aa_trans PF01490.18 AET41554.1 - 1.6e-76 257.6 27.0 1.9e-76 257.4 27.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Fasciclin PF02469.22 AET41555.1 - 2.6e-25 89.1 0.1 6.3e-05 23.2 0.1 5.8 5 1 0 5 5 5 5 Fasciclin domain Dynamin_M PF01031.20 AET41556.1 - 1.7e-108 362.2 0.0 3.5e-108 361.1 0.0 1.6 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 AET41556.1 - 5e-54 182.9 0.0 5e-54 182.9 0.0 3.0 3 1 0 3 3 3 1 Dynamin family GED PF02212.18 AET41556.1 - 1.1e-30 105.6 1.1 4e-30 103.8 1.1 2.1 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 AET41556.1 - 1.9e-05 24.7 0.2 0.0009 19.3 0.2 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase HAT_KAT11 PF08214.11 AET41557.1 - 9.5e-97 324.4 0.0 1.7e-96 323.6 0.0 1.4 1 1 0 1 1 1 1 Histone acetylation protein Tugs PF17840.1 AET41557.1 - 0.057 13.6 0.0 3.1 8.1 0.0 2.5 2 0 0 2 2 2 0 Tethering Ubl4a to BAGS domain Proteasome PF00227.26 AET41558.1 - 5.6e-47 159.7 0.6 6.4e-47 159.5 0.6 1.0 1 0 0 1 1 1 1 Proteasome subunit Sfi1_C PF10638.9 AET41559.1 - 2.8e-37 127.7 1.7 2.8e-37 127.7 1.7 3.1 4 0 0 4 4 4 1 Spindle body associated protein C-terminus Sfi1 PF08457.10 AET41559.1 - 4.2e-33 114.7 63.9 4.2e-28 98.2 48.8 3.2 1 1 2 3 3 3 3 Sfi1 spindle body protein Ribophorin_I PF04597.14 AET41560.1 - 3.3e-120 402.3 3.8 3.8e-120 402.1 3.8 1.0 1 0 0 1 1 1 1 Ribophorin I ORC_WH_C PF18137.1 AET41561.1 - 6.3e-23 81.4 0.0 1.3e-22 80.4 0.0 1.6 1 0 0 1 1 1 1 Origin recognition complex winged helix C-terminal ORC3_N PF07034.11 AET41561.1 - 3e-05 23.3 2.2 0.00067 18.9 3.2 2.5 2 1 0 2 2 2 1 Origin recognition complex (ORC) subunit 3 N-terminus COX16 PF14138.6 AET41562.1 - 3.2e-30 104.5 0.1 4.9e-30 103.9 0.1 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 RSN1_7TM PF02714.15 AET41563.1 - 9.6e-78 261.2 25.9 9.6e-78 261.2 25.9 2.8 4 0 0 4 4 4 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 AET41563.1 - 2.2e-29 102.2 2.3 2.2e-29 102.2 2.3 2.9 3 1 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_ext PF12621.8 AET41563.1 - 8.1e-08 32.3 0.0 1.8e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter PHM7_cyt PF14703.6 AET41563.1 - 0.0015 18.8 0.1 0.011 16.0 0.1 2.2 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter MMM1 PF10296.9 AET41564.1 - 3.5e-143 476.6 0.3 4.2e-143 476.4 0.3 1.1 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 CRR7 PF12095.8 AET41564.1 - 0.077 13.5 0.0 7.2 7.1 0.0 2.6 2 0 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 SYS1 PF09801.9 AET41565.1 - 2e-49 167.5 13.9 2.3e-49 167.2 13.9 1.1 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network PP2C PF00481.21 AET41566.1 - 5.3e-41 141.0 0.1 1e-40 140.0 0.1 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 AET41566.1 - 1.2e-39 133.9 83.8 3.9e-12 45.8 4.9 10.5 10 1 0 10 10 10 7 Leucine rich repeat LRR_4 PF12799.7 AET41566.1 - 1.2e-27 95.5 92.5 1.3e-07 31.8 2.5 12.4 9 2 3 12 12 12 7 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 AET41566.1 - 5.5e-25 88.1 0.0 1.3e-24 86.8 0.0 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_9 PF14580.6 AET41566.1 - 1.1e-06 28.3 32.8 0.0038 16.7 6.1 5.1 3 1 2 5 5 5 4 Leucine-rich repeat DUF3161 PF11362.8 AET41566.1 - 0.34 10.9 2.2 0.53 10.3 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3161) LRR_5 PF13306.6 AET41566.1 - 3.5 7.6 16.6 1.2 9.1 6.5 4.2 4 1 0 4 4 4 0 BspA type Leucine rich repeat region (6 copies) COX17 PF05051.13 AET41567.1 - 3.7e-22 78.4 6.3 4.4e-22 78.2 6.3 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.13 AET41567.1 - 0.00099 19.2 2.3 0.0013 18.8 2.3 1.3 1 0 0 1 1 1 1 CHCH domain PNP_UDP_1 PF01048.20 AET41568.1 - 3.1e-34 118.3 0.0 3.7e-34 118.0 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Hist_deacetyl PF00850.19 AET41569.1 - 7.3e-52 176.8 0.1 1.5e-51 175.8 0.1 1.5 1 0 0 1 1 1 1 Histone deacetylase domain SelP_N PF04592.14 AET41569.1 - 0.39 10.1 8.1 0.66 9.3 8.1 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Prok-TraM PF09228.10 AET41569.1 - 0.71 10.3 2.8 4.5 7.7 2.1 2.3 2 0 0 2 2 2 0 Prokaryotic Transcriptional repressor TraM Peptidase_C14 PF00656.22 AET41570.1 - 4.1e-62 210.4 0.0 5.1e-62 210.0 0.0 1.1 1 0 0 1 1 1 1 Caspase domain FapA PF03961.13 AET41571.1 - 8.4e-05 21.4 12.2 8.4e-05 21.4 12.2 4.1 2 1 2 4 4 4 1 Flagellar Assembly Protein A Baculo_PEP_C PF04513.12 AET41571.1 - 0.13 12.3 19.4 1.2 9.2 4.1 4.9 2 1 3 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus NUDIX PF00293.28 AET41572.1 - 5e-29 101.0 0.0 7.6e-29 100.4 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain SpoU_methylase PF00588.19 AET41573.1 - 8.2e-27 94.1 0.0 1.6e-26 93.2 0.0 1.5 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 AET41573.1 - 2.6e-15 56.4 0.1 4.6e-15 55.7 0.1 1.4 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding IGPD PF00475.18 AET41574.1 - 1.3e-59 200.7 1.6 2e-59 200.0 1.3 1.5 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase Mit_ribos_Mrp51 PF11709.8 AET41575.1 - 1.7e-64 218.7 4.0 3.3e-63 214.5 4.0 2.5 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit AA_permease PF00324.21 AET41576.1 - 3.9e-115 385.2 42.6 4.7e-115 384.9 42.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AET41576.1 - 1.1e-35 123.4 42.2 1.3e-35 123.1 42.2 1.0 1 0 0 1 1 1 1 Amino acid permease DEAD PF00270.29 AET41577.1 - 3.6e-48 163.6 0.0 1e-47 162.2 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET41577.1 - 2.2e-30 105.2 0.0 6.9e-30 103.7 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AET41577.1 - 0.0023 18.0 0.0 0.0069 16.4 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 AET41577.1 - 0.0038 16.5 0.0 0.006 15.8 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 AET41577.1 - 0.17 11.2 0.0 0.33 10.2 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit RNA_pol_Rpb2_6 PF00562.28 AET41578.1 - 9.7e-125 416.6 0.1 9.7e-125 416.6 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 AET41578.1 - 1.5e-59 200.9 2.2 2.6e-59 200.2 2.2 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 AET41578.1 - 5e-40 137.2 5.2 1.3e-39 135.8 4.9 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 AET41578.1 - 8.5e-34 115.8 0.3 5.5e-33 113.2 0.2 2.5 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 AET41578.1 - 1.4e-25 89.3 1.1 1.4e-25 89.3 1.1 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 AET41578.1 - 2.7e-18 65.9 0.0 5.9e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 AET41578.1 - 8.8e-11 42.2 0.7 3.5e-10 40.3 0.7 2.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Mei5 PF10376.9 AET41579.1 - 2.4e-21 76.5 14.2 3.1e-21 76.2 14.2 1.1 1 0 0 1 1 1 1 Double-strand recombination repair protein PBP5_C PF07943.13 AET41579.1 - 0.037 14.3 1.1 0.037 14.3 1.1 2.1 2 0 0 2 2 2 0 Penicillin-binding protein 5, C-terminal domain Fungal_trans_2 PF11951.8 AET41579.1 - 0.19 10.5 2.2 0.44 9.3 0.1 1.9 2 0 0 2 2 2 0 Fungal specific transcription factor domain BACK PF07707.15 AET41579.1 - 0.82 9.8 6.2 0.47 10.6 4.2 1.7 2 0 0 2 2 2 0 BTB And C-terminal Kelch DUF4407 PF14362.6 AET41579.1 - 1.9 7.8 9.8 3.2 7.0 9.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Noc2 PF03715.13 AET41580.1 - 1.7e-125 418.3 1.7 1.7e-125 418.3 1.7 2.1 2 0 0 2 2 2 1 Noc2p family DUF5081 PF16887.5 AET41580.1 - 0.015 14.4 2.0 0.029 13.4 2.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5081) MMR_HSR1 PF01926.23 AET41581.1 - 2.2e-08 34.1 0.0 1.3e-07 31.7 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AET41581.1 - 0.00034 20.6 0.0 0.00075 19.4 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 AET41581.1 - 0.0022 17.5 0.0 0.048 13.2 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 AET41581.1 - 0.013 15.6 0.0 0.059 13.4 0.0 2.1 2 0 0 2 2 2 0 Dynamin family RNA_helicase PF00910.22 AET41581.1 - 0.075 13.4 0.1 10 6.5 0.0 2.8 2 0 0 2 2 2 0 RNA helicase GTP_EFTU PF00009.27 AET41581.1 - 0.14 11.6 0.0 1.2 8.6 0.0 2.3 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 AET41581.1 - 0.16 12.1 0.0 0.32 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain APG6 PF04111.12 AET41582.1 - 5.1e-63 212.3 0.2 1e-62 211.3 0.2 1.5 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 AET41582.1 - 3.6e-22 79.3 17.0 8.3e-22 78.1 17.0 1.6 1 0 0 1 1 1 1 Apg6 coiled-coil region RNF220 PF15926.5 AET41582.1 - 0.034 13.8 2.0 0.075 12.6 2.0 1.5 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 ORC_WH_C PF18137.1 AET41582.1 - 0.096 12.8 2.3 0.2 11.7 2.3 1.4 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal FAM76 PF16046.5 AET41582.1 - 0.36 10.1 6.0 0.59 9.4 6.0 1.4 1 0 0 1 1 1 0 FAM76 protein YabA PF06156.13 AET41582.1 - 4.3 8.0 10.9 2.8 8.6 7.1 2.7 2 1 1 3 3 3 0 Initiation control protein YabA Ribonuc_red_lgC PF02867.15 AET41583.1 - 1.7e-178 594.4 0.0 2.1e-178 594.2 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 AET41583.1 - 1.9e-23 82.2 0.0 4.9e-23 80.9 0.0 1.7 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 AET41583.1 - 0.013 16.1 0.0 0.036 14.6 0.0 1.8 2 0 0 2 2 2 0 ATP cone domain Ribonuclease_T2 PF00445.18 AET41584.1 - 8.6e-42 143.4 0.0 1e-41 143.1 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family Spc29 PF17082.5 AET41585.1 - 4.1e-51 174.2 2.1 7.1e-51 173.4 2.1 1.4 1 1 0 1 1 1 1 Spindle Pole Component 29 Fez1 PF06818.15 AET41585.1 - 0.01 16.3 4.6 0.068 13.6 0.3 2.1 2 0 0 2 2 2 0 Fez1 MCR_gamma PF02240.16 AET41585.1 - 0.02 14.2 0.0 2.2 7.4 0.0 2.2 2 0 0 2 2 2 0 Methyl-coenzyme M reductase gamma subunit Phage_HK97_TLTM PF06120.11 AET41585.1 - 0.023 13.9 0.4 0.023 13.9 0.4 1.5 2 0 0 2 2 2 0 Tail length tape measure protein DUF2576 PF10845.8 AET41585.1 - 0.66 9.6 0.1 0.66 9.6 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2576) DUF2951 PF11166.8 AET41585.1 - 1.5 9.1 4.8 0.28 11.4 1.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) Y_phosphatase PF00102.27 AET41586.1 - 4.6e-58 196.6 1.8 2.7e-57 194.0 1.8 2.1 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 AET41586.1 - 0.0036 17.3 0.0 0.0081 16.1 0.0 1.6 1 0 0 1 1 1 1 Tyrosine phosphatase family HBD PF18534.1 AET41586.1 - 0.022 14.9 0.1 9.5 6.4 0.1 2.6 2 0 0 2 2 2 0 Helical bundle domain DSPc PF00782.20 AET41586.1 - 0.061 13.1 0.1 0.49 10.2 0.0 2.5 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain BLI1 PF17324.2 AET41586.1 - 0.08 13.6 0.5 17 6.1 0.1 2.9 2 0 0 2 2 2 0 BLOC-1 interactor 1 IBN_N PF03810.19 AET41587.1 - 1.3e-13 50.6 0.5 1.2e-12 47.6 0.2 2.9 3 0 0 3 3 3 1 Importin-beta N-terminal domain ACDC PF14733.6 AET41587.1 - 0.021 15.2 0.0 0.11 12.8 0.0 2.4 1 0 0 1 1 1 0 AP2-coincident C-terminal HEAT_2 PF13646.6 AET41587.1 - 0.053 13.9 0.0 30 5.1 0.0 3.5 3 0 0 3 3 3 0 HEAT repeats NAPRTase PF04095.16 AET41588.1 - 1.6e-69 234.2 0.0 2e-69 233.8 0.0 1.1 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 AET41588.1 - 1.7e-34 118.9 0.7 2.8e-34 118.2 0.7 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain DUF2729 PF10870.8 AET41589.1 - 4.5 7.2 7.4 0.19 11.6 1.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2729) ANAPC4_WD40 PF12894.7 AET41590.1 - 0.00013 22.2 0.2 27 5.2 0.0 5.5 5 0 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AET41590.1 - 0.00033 21.4 8.0 0.24 12.3 0.2 6.1 6 1 1 7 7 7 1 WD domain, G-beta repeat Cyc-maltodext_C PF10438.9 AET41590.1 - 3.9 7.6 5.3 37 4.5 0.2 3.3 3 0 0 3 3 3 0 Cyclo-malto-dextrinase C-terminal domain RNA_pol_N PF01194.17 AET41591.1 - 4.2e-30 103.8 0.5 4.8e-30 103.6 0.5 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 AET41591.1 - 0.036 14.3 0.2 0.047 13.9 0.2 1.3 1 0 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Dynamin_N PF00350.23 AET41592.1 - 3.3e-41 141.1 0.0 1.2e-40 139.3 0.0 2.1 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 AET41592.1 - 5.3e-05 23.3 0.0 0.00031 20.8 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_M PF01031.20 AET41592.1 - 9.3e-05 21.8 9.1 0.037 13.2 0.0 3.0 2 1 0 2 2 2 2 Dynamin central region AAA_16 PF13191.6 AET41592.1 - 0.019 15.4 0.6 0.11 12.8 0.0 2.5 3 1 0 3 3 3 0 AAA ATPase domain AKAP7_RIRII_bdg PF10470.9 AET41592.1 - 0.072 13.2 0.4 0.24 11.5 0.1 2.1 2 0 0 2 2 2 0 PKA-RI-RII subunit binding domain of A-kinase anchor protein Linker_histone PF00538.19 AET41593.1 - 8.5e-23 80.5 0.0 8.5e-23 80.5 0.0 3.1 1 1 2 3 3 3 1 linker histone H1 and H5 family HC2 PF07382.11 AET41593.1 - 5.4e-06 26.6 49.7 9.6e-06 25.8 49.7 1.4 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 TRF PF08558.10 AET41594.1 - 1.3e-72 244.2 0.0 2e-72 243.7 0.0 1.2 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 AET41594.1 - 4.9e-06 26.6 1.0 2.1e-05 24.6 1.0 2.1 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AET41594.1 - 0.069 13.4 0.1 0.16 12.2 0.1 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF5559 PF17714.1 AET41594.1 - 0.098 12.5 0.3 0.17 11.8 0.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5559) Med3 PF11593.8 AET41594.1 - 5.8 6.0 12.8 9.9 5.2 12.8 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal WD40 PF00400.32 AET41595.1 - 6e-30 102.9 23.2 4.3e-06 27.4 0.1 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AET41595.1 - 4.1e-15 55.9 0.2 0.062 13.6 0.1 5.5 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AET41595.1 - 1.1e-05 24.6 2.8 1.4 7.8 0.1 4.1 3 1 1 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 AET41595.1 - 0.0022 17.4 2.7 0.67 9.2 0.3 3.0 3 1 1 4 4 4 2 WD40-like domain YEATS PF03366.16 AET41596.1 - 1.2e-16 60.4 0.1 2.3e-16 59.5 0.1 1.5 1 0 0 1 1 1 1 YEATS family YEATS PF03366.16 AET41597.1 - 1e-20 73.4 0.0 2.2e-20 72.4 0.0 1.5 2 0 0 2 2 2 1 YEATS family BET PF17035.5 AET41597.1 - 1.1e-06 28.7 0.0 2e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation YqeY PF09424.10 AET41598.1 - 2.1e-22 79.8 3.1 2.8e-22 79.3 3.1 1.1 1 0 0 1 1 1 1 Yqey-like protein tRNA_NucTran2_2 PF13735.6 AET41598.1 - 0.0022 18.0 3.0 0.0037 17.3 3.0 1.5 1 1 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative SDH_sah PF01972.16 AET41598.1 - 0.014 14.4 1.4 0.017 14.2 1.4 1.1 1 0 0 1 1 1 0 Serine dehydrogenase proteinase Staphylokinase PF02821.16 AET41598.1 - 0.046 14.2 3.4 0.069 13.6 3.4 1.2 1 0 0 1 1 1 0 Staphylokinase/Streptokinase family Na_Ca_ex_C PF16494.5 AET41598.1 - 0.18 12.3 4.0 1.1 9.7 4.0 2.2 1 1 0 1 1 1 0 C-terminal extension of sodium/calcium exchanger domain GRAB PF10375.9 AET41599.1 - 9e-07 28.5 6.0 1.3e-06 28.0 2.3 2.4 2 0 0 2 2 2 1 GRIP-related Arf-binding domain AAA_13 PF13166.6 AET41599.1 - 0.0011 17.8 28.8 0.0011 17.8 28.8 2.3 1 1 1 2 2 2 1 AAA domain TMF_DNA_bd PF12329.8 AET41599.1 - 0.0013 18.7 9.6 0.0013 18.7 9.6 5.5 2 1 2 5 5 4 1 TATA element modulatory factor 1 DNA binding Atg14 PF10186.9 AET41599.1 - 0.018 14.1 45.0 0.0071 15.5 17.6 3.4 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Med9 PF07544.13 AET41599.1 - 0.026 14.6 37.2 0.62 10.2 5.7 4.6 2 2 3 5 5 5 0 RNA polymerase II transcription mediator complex subunit 9 Spc7 PF08317.11 AET41599.1 - 0.044 12.7 59.2 0.2 10.5 21.6 3.5 1 1 2 3 3 3 0 Spc7 kinetochore protein HMMR_N PF15905.5 AET41599.1 - 0.094 12.2 63.9 0.28 10.6 27.7 3.1 1 1 2 3 3 3 0 Hyaluronan mediated motility receptor N-terminal ERM PF00769.19 AET41599.1 - 0.12 12.1 56.0 0.037 13.8 23.2 3.1 1 1 1 3 3 3 0 Ezrin/radixin/moesin family ATG16 PF08614.11 AET41599.1 - 0.14 12.4 53.3 0.6 10.3 20.4 4.0 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) DUF3584 PF12128.8 AET41599.1 - 0.14 9.6 47.2 0.31 8.5 47.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) FPP PF05911.11 AET41599.1 - 0.18 10.0 61.2 0.49 8.5 27.7 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil TACC_C PF05010.14 AET41599.1 - 0.21 11.4 48.0 0.77 9.5 22.2 2.8 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ADIP PF11559.8 AET41599.1 - 0.23 11.5 52.1 0.059 13.4 16.5 4.3 1 1 4 5 5 5 0 Afadin- and alpha -actinin-Binding DUF1664 PF07889.12 AET41599.1 - 0.26 11.3 38.1 0.29 11.2 12.2 4.4 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) Tiam_CC_Ex PF18385.1 AET41599.1 - 0.36 11.2 3.7 1.5 9.2 3.7 2.1 1 0 0 1 1 1 0 T-lymphoma invasion and metastasis CC-Ex domain M_domain PF12938.7 AET41599.1 - 0.44 10.3 12.0 0.9 9.3 12.0 1.4 1 0 0 1 1 1 0 M domain of GW182 SlyX PF04102.12 AET41599.1 - 0.45 11.2 43.5 4.6 7.9 0.0 6.8 1 1 6 7 7 7 0 SlyX LPP PF04728.13 AET41599.1 - 1.2 9.6 0.0 1.2 9.6 0.0 5.8 4 2 3 7 7 7 0 Lipoprotein leucine-zipper KR PF08659.10 AET41599.1 - 2.5 8.0 5.8 13 5.6 1.0 2.6 2 0 0 2 2 2 0 KR domain DUF4201 PF13870.6 AET41599.1 - 2.5 7.8 51.0 2 8.1 15.7 3.7 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) MbeD_MobD PF04899.12 AET41599.1 - 3 8.0 20.0 0.64 10.2 3.7 3.5 3 1 0 3 3 3 0 MbeD/MobD like IFT57 PF10498.9 AET41599.1 - 5.7 5.8 48.1 0.42 9.5 22.6 2.5 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 GAS PF13851.6 AET41599.1 - 5.8 6.2 60.7 7 5.9 7.2 4.3 1 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding FliJ PF02050.16 AET41599.1 - 6 7.1 44.5 0.39 10.9 17.0 4.3 1 1 3 4 4 4 0 Flagellar FliJ protein Jnk-SapK_ap_N PF09744.9 AET41599.1 - 6.9 6.9 60.0 1.3 9.2 19.3 3.8 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 TMF_TATA_bd PF12325.8 AET41599.1 - 8.2 6.7 58.3 0.38 11.0 6.2 4.8 1 1 4 5 5 5 0 TATA element modulatory factor 1 TATA binding RFC1 PF08519.12 AET41600.1 - 1.1e-55 188.1 1.6 2e-55 187.2 0.2 2.1 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain AAA PF00004.29 AET41600.1 - 1.6e-12 48.0 0.0 4.7e-12 46.5 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.26 AET41600.1 - 2.8e-11 43.6 0.0 8.6e-11 42.1 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Rad17 PF03215.15 AET41600.1 - 1.1e-05 25.5 0.0 2.6e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 AET41600.1 - 3.9e-05 23.4 0.0 8.9e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AET41600.1 - 0.00019 21.9 0.0 0.00084 19.8 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 AET41600.1 - 0.00033 20.8 0.0 0.00093 19.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 AET41600.1 - 0.00033 21.1 1.9 0.016 15.7 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 AET41600.1 - 0.00083 19.6 0.0 0.011 16.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_assoc_2 PF16193.5 AET41600.1 - 0.0015 18.9 0.0 0.0062 16.9 0.0 2.1 1 0 0 1 1 1 1 AAA C-terminal domain AAA_18 PF13238.6 AET41600.1 - 0.0035 17.9 0.0 0.012 16.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 AET41600.1 - 0.0036 17.7 0.0 0.011 16.1 0.0 1.9 1 0 0 1 1 1 1 RNA helicase DUF4355 PF14265.6 AET41600.1 - 0.0051 17.0 4.2 0.0051 17.0 4.2 2.6 2 0 0 2 2 1 1 Domain of unknown function (DUF4355) AAA_14 PF13173.6 AET41600.1 - 0.0072 16.4 0.0 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AET41600.1 - 0.028 14.4 0.0 0.13 12.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 AET41600.1 - 0.033 13.9 0.0 0.1 12.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 AET41600.1 - 0.053 13.4 0.0 0.54 10.1 0.0 2.6 3 0 0 3 3 3 0 NACHT domain NTPase_1 PF03266.15 AET41600.1 - 0.068 13.1 0.1 0.39 10.6 0.0 2.3 1 1 0 2 2 2 0 NTPase PTCB-BRCT PF12738.7 AET41600.1 - 0.15 12.1 0.2 0.57 10.2 0.0 2.1 2 0 0 2 2 2 0 twin BRCT domain DPPIV_N PF00930.21 AET41601.1 - 6.5e-88 294.8 2.9 8.8e-88 294.4 2.9 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 AET41601.1 - 9.9e-48 162.4 0.2 1.8e-47 161.6 0.1 1.5 2 0 0 2 2 2 1 Prolyl oligopeptidase family PAF-AH_p_II PF03403.13 AET41601.1 - 0.0022 16.6 0.0 0.045 12.3 0.0 2.1 2 0 0 2 2 2 1 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_6 PF12697.7 AET41601.1 - 0.0024 18.5 0.0 0.42 11.2 0.0 2.4 1 1 1 2 2 2 2 Alpha/beta hydrolase family Esterase PF00756.20 AET41601.1 - 0.07 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Putative esterase EFP_N PF08207.12 AET41601.1 - 0.094 12.8 0.0 10 6.3 0.0 2.5 2 0 0 2 2 2 0 Elongation factor P (EF-P) KOW-like domain Ribosomal_L5e PF17144.4 AET41602.1 - 8.8e-83 276.2 1.3 2.6e-82 274.7 0.0 2.0 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 AET41602.1 - 3e-31 108.2 5.4 3e-31 108.2 5.4 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Ribosomal_L18p PF00861.22 AET41602.1 - 0.026 14.9 0.7 0.056 13.8 0.0 1.8 2 0 0 2 2 2 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast DAG_kinase_N PF14513.6 AET41602.1 - 0.037 14.2 0.4 0.08 13.2 0.4 1.5 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus Thr_synth_N PF14821.6 AET41602.1 - 0.038 14.2 0.2 0.86 9.9 0.0 2.7 3 0 0 3 3 3 0 Threonine synthase N terminus CtaG_Cox11 PF04442.14 AET41604.1 - 6.4e-61 204.8 0.1 1.1e-60 204.0 0.1 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 Zn_clus PF00172.18 AET41605.1 - 9.5e-05 22.4 9.4 0.00021 21.3 9.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Acyl_transf_1 PF00698.21 AET41606.1 - 0.055 13.0 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Acyl transferase domain Mito_carr PF00153.27 AET41607.1 - 2e-62 207.1 0.2 1.7e-23 82.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2407_C PF13373.6 AET41608.1 - 3.7e-37 127.6 0.5 7.6e-37 126.6 0.5 1.5 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 AET41608.1 - 6.3e-16 58.8 1.7 2.8e-13 50.3 0.1 2.4 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain TMEM65 PF10507.9 AET41608.1 - 0.054 13.4 0.5 0.092 12.7 0.1 1.6 2 0 0 2 2 2 0 Transmembrane protein 65 Deltameth_res PF16020.5 AET41608.1 - 0.43 10.5 1.4 0.56 10.1 0.0 1.9 2 0 0 2 2 2 0 Deltamethrin resistance RNA_pol_Rpb8 PF03870.15 AET41609.1 - 2.2e-45 154.3 0.0 2.8e-45 153.9 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 AET41609.1 - 0.014 15.4 0.3 1.8 8.6 0.0 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase, subunit G NifU_N PF01592.16 AET41610.1 - 2.4e-57 192.6 0.1 2.8e-57 192.4 0.1 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain TSCPD PF12637.7 AET41610.1 - 0.038 14.2 0.1 0.071 13.4 0.1 1.4 1 0 0 1 1 1 0 TSCPD domain Sensor PF13796.6 AET41612.1 - 0.0072 16.4 0.2 0.012 15.7 0.2 1.4 1 0 0 1 1 1 1 Putative sensor PHD PF00628.29 AET41613.1 - 1.7e-11 43.8 4.2 1.7e-11 43.8 4.2 3.0 3 0 0 3 3 3 1 PHD-finger WD40 PF00400.32 AET41614.1 - 2.1e-07 31.5 4.9 0.057 14.3 0.1 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat Pkinase PF00069.25 AET41615.1 - 5.5e-72 242.3 0.0 7.6e-72 241.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET41615.1 - 3e-37 128.3 0.0 5e-37 127.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET41615.1 - 6.3e-07 29.0 0.0 1.2e-06 28.0 0.0 1.5 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.6 AET41615.1 - 8.4e-06 25.6 0.1 0.046 13.3 0.0 2.3 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 AET41615.1 - 6.5e-05 21.9 0.0 0.00012 21.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 AET41615.1 - 0.001 18.4 0.0 0.0018 17.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AET41615.1 - 0.013 15.4 0.0 0.13 12.1 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family GrpE PF01025.19 AET41616.1 - 3.3e-49 166.8 4.2 4.1e-49 166.4 4.2 1.1 1 0 0 1 1 1 1 GrpE PKcGMP_CC PF16808.5 AET41616.1 - 0.0018 18.1 2.9 0.0046 16.8 2.9 1.6 1 0 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase TACC_C PF05010.14 AET41616.1 - 0.017 14.9 7.0 0.26 11.1 0.2 2.1 1 1 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Pkinase PF00069.25 AET41617.1 - 2.5e-64 217.2 0.0 4.2e-64 216.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET41617.1 - 1.4e-37 129.4 0.0 2.3e-37 128.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AET41617.1 - 2e-08 33.9 0.0 3.7e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AET41617.1 - 0.12 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ribosomal_L35Ae PF01247.18 AET41618.1 - 3.4e-42 142.5 0.6 3.8e-42 142.4 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 AET41618.1 - 0.00022 21.4 0.0 0.13 12.4 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain Ran_BP1 PF00638.18 AET41619.1 - 6.4e-34 116.8 0.4 1.5e-33 115.6 0.4 1.7 1 0 0 1 1 1 1 RanBP1 domain NUP50 PF08911.11 AET41619.1 - 4.5e-14 52.9 0.4 4.2e-13 49.7 0.4 2.8 1 0 0 1 1 1 1 NUP50 (Nucleoporin 50 kDa) AAA PF00004.29 AET41620.1 - 1.1e-37 129.4 0.0 1.7e-37 128.8 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AET41620.1 - 3.9e-10 39.4 0.0 8.3e-10 38.3 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_14 PF13173.6 AET41620.1 - 9.9e-07 28.9 0.0 2.7e-06 27.4 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 AET41620.1 - 2e-06 28.3 0.9 0.00022 21.7 0.1 3.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 AET41620.1 - 2.8e-06 27.4 0.0 2.1e-05 24.5 0.0 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 AET41620.1 - 5.7e-06 26.2 0.0 1.2e-05 25.1 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 AET41620.1 - 9.3e-06 26.0 0.2 0.012 15.8 0.0 3.2 1 1 2 3 3 3 1 AAA domain Sigma54_activ_2 PF14532.6 AET41620.1 - 4.9e-05 23.5 0.0 8.5e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_2 PF07724.14 AET41620.1 - 8.7e-05 22.7 0.0 0.00018 21.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) TniB PF05621.11 AET41620.1 - 8.9e-05 22.0 0.0 0.38 10.1 0.0 2.7 2 1 1 3 3 3 2 Bacterial TniB protein IstB_IS21 PF01695.17 AET41620.1 - 0.00018 21.3 0.0 0.00033 20.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 AET41620.1 - 0.0004 20.9 0.0 0.00097 19.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 AET41620.1 - 0.00058 19.1 0.0 0.00089 18.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 AET41620.1 - 0.00092 18.6 0.2 0.0025 17.2 0.1 1.6 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 AET41620.1 - 0.0014 19.0 0.0 0.0041 17.5 0.0 2.0 1 1 0 1 1 1 1 RNA helicase AAA_24 PF13479.6 AET41620.1 - 0.0014 18.3 0.0 0.0024 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 AET41620.1 - 0.0018 17.9 0.2 0.037 13.6 0.1 2.2 1 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 AET41620.1 - 0.0021 17.6 0.0 0.0085 15.6 0.0 1.9 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_33 PF13671.6 AET41620.1 - 0.0042 17.2 0.0 0.013 15.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 AET41620.1 - 0.0095 15.9 0.1 0.025 14.5 0.0 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain Zeta_toxin PF06414.12 AET41620.1 - 0.011 15.0 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Hydin_ADK PF17213.3 AET41620.1 - 0.015 15.6 0.2 0.97 9.7 0.0 2.4 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain AAA_17 PF13207.6 AET41620.1 - 0.019 15.4 0.0 0.053 13.9 0.0 1.8 2 0 0 2 2 1 0 AAA domain Sigma54_activat PF00158.26 AET41620.1 - 0.02 14.6 0.0 0.063 13.0 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain Parvo_NS1 PF01057.17 AET41620.1 - 0.022 13.9 0.0 0.039 13.1 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TIP49 PF06068.13 AET41620.1 - 0.026 13.7 0.1 0.073 12.3 0.0 1.7 1 1 1 2 2 2 0 TIP49 P-loop domain NACHT PF05729.12 AET41620.1 - 0.029 14.3 0.0 0.088 12.7 0.0 1.8 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.6 AET41620.1 - 0.03 14.6 0.1 0.08 13.2 0.0 1.8 2 0 0 2 2 1 0 AAA domain Bac_DnaA PF00308.18 AET41620.1 - 0.04 13.8 0.0 0.083 12.7 0.0 1.5 1 1 0 1 1 1 0 Bacterial dnaA protein ABC_tran PF00005.27 AET41620.1 - 0.041 14.4 0.0 0.087 13.3 0.0 1.9 1 1 0 1 1 1 0 ABC transporter SMC_N PF02463.19 AET41620.1 - 0.048 13.1 0.1 6.9 6.0 0.0 2.2 1 1 1 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_3 PF07726.11 AET41620.1 - 0.059 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_6 PF12774.7 AET41620.1 - 0.098 11.6 0.0 0.16 10.9 0.0 1.3 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region tRNA_lig_kinase PF08303.11 AET41620.1 - 0.1 12.7 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 tRNA ligase kinase domain FCH PF00611.23 AET41620.1 - 0.11 12.8 0.0 0.67 10.3 0.0 2.2 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain Viral_helicase1 PF01443.18 AET41620.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TsaE PF02367.17 AET41620.1 - 0.12 12.4 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE KAP_NTPase PF07693.14 AET41620.1 - 0.14 11.4 1.4 6.8 5.8 0.0 2.7 2 1 1 3 3 3 0 KAP family P-loop domain ATPase_2 PF01637.18 AET41620.1 - 0.15 12.0 0.1 0.83 9.5 0.0 2.1 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea Evr1_Alr PF04777.13 AET41621.1 - 4.6e-30 104.0 2.9 4.6e-30 104.0 2.9 1.5 2 0 0 2 2 2 1 Erv1 / Alr family LolA_2 PF16584.5 AET41621.1 - 0.12 12.3 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA WH2 PF02205.20 AET41622.1 - 7.9e-12 44.6 0.2 1.5e-09 37.3 0.5 2.7 2 0 0 2 2 2 2 WH2 motif Adap_comp_sub PF00928.21 AET41623.1 - 4.7e-91 304.8 0.8 5.9e-91 304.5 0.8 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 AET41623.1 - 5e-07 29.8 1.0 9.3e-07 28.9 1.0 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain HBB PF06777.11 AET41623.1 - 0.063 12.9 0.2 0.1 12.3 0.2 1.3 1 0 0 1 1 1 0 Helical and beta-bridge domain AhpC-TSA PF00578.21 AET41624.1 - 2.4e-29 101.7 0.1 3.2e-29 101.4 0.1 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AET41624.1 - 3.8e-20 72.1 0.0 4.9e-20 71.7 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 AET41624.1 - 0.0012 18.9 0.0 0.002 18.3 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme DUF1644 PF07800.12 AET41624.1 - 0.035 14.2 0.0 0.061 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1644) DUF2408 PF10303.9 AET41625.1 - 2.5e-61 206.1 12.4 1.7e-42 145.2 0.3 5.1 3 2 1 4 4 4 3 Protein of unknown function (DUF2408) SPAM PF02090.15 AET41625.1 - 0.01 15.7 2.9 1.4 8.7 0.1 3.4 3 0 0 3 3 3 2 Salmonella surface presentation of antigen gene type M protein Vac_Fusion PF02346.16 AET41625.1 - 0.037 13.7 1.7 0.17 11.6 0.2 2.8 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 GTP-bdg_M PF16360.5 AET41625.1 - 0.19 12.3 0.6 3.8 8.2 0.1 2.9 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region DED PF01335.21 AET41625.1 - 0.27 11.6 3.0 1 9.7 0.1 3.5 4 0 0 4 4 4 0 Death effector domain Baculo_p24 PF05073.12 AET41625.1 - 5.4 6.8 8.1 4.9 6.9 0.1 3.8 4 1 0 5 5 5 0 Baculovirus P24 capsid protein WSC PF01822.19 AET41626.1 - 1.1e-08 35.1 13.3 1.1e-08 35.1 13.3 1.9 2 1 0 2 2 2 1 WSC domain DUF5305 PF17231.2 AET41626.1 - 0.0038 16.7 0.1 0.0058 16.1 0.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5305) Podoplanin PF05808.11 AET41626.1 - 0.011 15.9 7.0 0.026 14.7 7.0 1.6 1 0 0 1 1 1 0 Podoplanin Yip1 PF04893.17 AET41626.1 - 0.019 14.7 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 Yip1 domain DUF2207 PF09972.9 AET41626.1 - 0.029 13.2 0.0 0.036 12.8 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TMEM51 PF15345.6 AET41626.1 - 0.031 14.1 1.8 0.038 13.8 0.1 1.8 1 1 0 1 1 1 0 Transmembrane protein 51 DUF2062 PF09835.9 AET41626.1 - 0.035 14.0 0.0 0.054 13.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) MscL PF01741.18 AET41626.1 - 0.14 12.5 0.0 0.23 11.8 0.0 1.2 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL DUF4064 PF13273.6 AET41626.1 - 0.15 12.4 1.9 1.4 9.3 0.0 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF4064) DUF5122 PF17164.4 AET41626.1 - 0.4 11.0 3.0 1.3 9.4 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5122) beta-propeller Macoilin PF09726.9 AET41626.1 - 1.6 7.2 3.9 1.9 6.9 3.9 1.2 1 0 0 1 1 1 0 Macoilin family TMEM154 PF15102.6 AET41626.1 - 6 6.8 11.3 5.9 6.8 0.3 2.5 1 1 1 2 2 2 0 TMEM154 protein family Hap4_Hap_bind PF10297.9 AET41627.1 - 2.5e-07 30.6 4.8 5.7e-07 29.4 4.8 1.6 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.21 AET41627.1 - 1.3e-06 28.4 21.5 0.00034 20.6 13.7 2.5 1 1 1 2 2 2 2 bZIP transcription factor GBR2_CC PF18455.1 AET41627.1 - 0.064 13.4 1.6 0.19 11.8 1.6 1.8 1 0 0 1 1 1 0 Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain Tox-ODYAM1 PF15642.6 AET41627.1 - 0.08 11.9 3.8 0.15 11.0 3.8 1.4 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus bZIP_2 PF07716.15 AET41627.1 - 0.081 13.0 22.3 3.4 7.8 4.5 2.8 1 1 1 2 2 2 0 Basic region leucine zipper KLRAQ PF10205.9 AET41627.1 - 0.11 12.8 2.9 0.24 11.6 2.9 1.7 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein CLZ PF16526.5 AET41627.1 - 0.46 10.9 6.6 0.35 11.2 4.3 2.1 2 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels UPF0242 PF06785.11 AET41627.1 - 1.1 9.3 5.6 1.9 8.5 5.6 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_Maf PF03131.17 AET41627.1 - 4 8.0 14.7 1 9.9 8.6 2.3 1 1 1 2 2 2 0 bZIP Maf transcription factor DMPK_coil PF08826.10 AET41627.1 - 7.3 6.8 10.4 7.1 6.8 6.3 2.7 2 0 0 2 2 2 0 DMPK coiled coil domain like Glyco_hydro_72 PF03198.14 AET41628.1 - 1.1e-139 465.0 3.3 1.4e-139 464.8 3.3 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 AET41628.1 - 0.00035 20.1 0.0 0.0014 18.1 0.0 1.9 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 AET41628.1 - 0.054 12.6 0.1 0.11 11.5 0.1 1.6 1 1 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain GIT_SHD PF08518.11 AET41629.1 - 1.6e-25 88.4 8.4 3.2e-13 49.1 0.7 3.3 3 0 0 3 3 3 2 Spa2 homology domain (SHD) of GIT GIT1_C PF12205.8 AET41629.1 - 8.5e-05 22.6 0.9 8.5e-05 22.6 0.9 3.4 2 1 2 4 4 4 1 G protein-coupled receptor kinase-interacting protein 1 C term TMF_DNA_bd PF12329.8 AET41629.1 - 0.00025 21.0 6.8 0.00025 21.0 6.8 5.0 2 2 1 3 3 3 1 TATA element modulatory factor 1 DNA binding DUF1664 PF07889.12 AET41629.1 - 0.0083 16.2 3.9 0.0083 16.2 3.9 4.1 2 1 1 3 3 3 1 Protein of unknown function (DUF1664) HalX PF08663.10 AET41629.1 - 0.32 11.3 4.9 3.5 8.0 0.1 3.4 2 0 0 2 2 2 0 HalX domain HOOK PF05622.12 AET41629.1 - 1.9 6.5 30.4 3.3 5.7 6.8 3.0 1 1 1 2 2 2 0 HOOK protein GvpG PF05120.12 AET41629.1 - 3.3 7.8 6.6 6.8 6.8 0.5 2.8 2 0 0 2 2 2 0 Gas vesicle protein G YabA PF06156.13 AET41629.1 - 3.5 8.3 32.7 0.31 11.7 3.5 5.9 2 1 3 5 5 5 0 Initiation control protein YabA LPP PF04728.13 AET41629.1 - 5.2 7.5 12.5 0.51 10.8 1.5 4.7 2 1 1 4 4 4 0 Lipoprotein leucine-zipper Ribonucleas_3_3 PF14622.6 AET41630.1 - 4.3e-16 59.2 0.0 7e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 AET41630.1 - 0.062 13.9 0.0 0.16 12.6 0.0 1.7 1 1 0 1 1 1 0 Ribonuclease III domain DEAD PF00270.29 AET41631.1 - 4.6e-41 140.5 1.0 1e-40 139.4 0.1 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AET41631.1 - 4.5e-32 110.7 5.5 7.3e-29 100.3 0.0 3.2 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 AET41631.1 - 2.6e-07 30.8 0.8 5e-07 29.9 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 AET41631.1 - 0.045 14.0 1.1 0.48 10.7 1.1 2.4 1 1 0 1 1 1 0 AAA domain ATP-synt_G PF04718.15 AET41632.1 - 2.3e-25 89.3 0.0 2.7e-25 89.1 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit MCM PF00493.23 AET41633.1 - 9.8e-101 335.5 0.0 1.6e-100 334.9 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AET41633.1 - 1.2e-37 128.6 0.4 2.6e-37 127.5 0.4 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AET41633.1 - 2.9e-29 101.3 3.4 7.8e-29 99.9 1.8 2.4 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 AET41633.1 - 1.9e-19 70.2 1.3 7e-19 68.4 1.3 2.1 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 AET41633.1 - 4.5e-06 26.2 0.0 0.00018 20.9 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 AET41633.1 - 8.8e-06 25.8 0.0 3.5e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 AET41633.1 - 0.00057 19.8 0.0 0.0076 16.1 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF3465 PF11948.8 AET41633.1 - 0.022 14.7 0.6 0.068 13.1 0.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3465) AAA_16 PF13191.6 AET41633.1 - 0.025 15.0 0.3 1.4 9.2 0.1 3.1 2 1 0 2 2 2 0 AAA ATPase domain Sigma54_activat PF00158.26 AET41633.1 - 0.11 12.2 0.1 3 7.5 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain EI24 PF07264.11 AET41634.1 - 8e-06 26.2 11.6 1.2e-05 25.7 11.6 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) RICTOR_V PF14668.6 AET41634.1 - 0.011 16.0 0.5 0.066 13.5 0.1 2.4 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 CAF1A PF12253.8 AET41635.1 - 3.9e-22 78.2 9.1 3.9e-22 78.2 9.1 3.8 2 1 0 2 2 2 1 Chromatin assembly factor 1 subunit A Borrelia_P83 PF05262.11 AET41635.1 - 0.91 7.9 30.0 1.5 7.3 30.0 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein GREB1 PF15782.5 AET41635.1 - 4.9 4.1 10.9 6.7 3.7 10.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CAF-1_p150 PF11600.8 AET41635.1 - 5.2 6.7 65.2 0.06 13.1 57.1 1.9 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal SHE3 PF17078.5 AET41636.1 - 0.0042 16.8 0.4 0.01 15.6 0.4 1.6 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 eIF-6 PF01912.18 AET41637.1 - 1.7e-81 272.3 0.9 2.2e-81 272.0 0.9 1.1 1 0 0 1 1 1 1 eIF-6 family Cys_Met_Meta_PP PF01053.20 AET41638.1 - 8.2e-135 449.2 0.0 9.7e-135 449.0 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 AET41638.1 - 9.5e-09 35.0 0.0 2.9e-08 33.4 0.0 1.7 3 0 0 3 3 3 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 AET41638.1 - 3e-08 33.2 0.0 4.7e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AET41638.1 - 8.5e-08 31.5 0.1 1.3e-07 30.9 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 AET41638.1 - 2.3e-05 23.8 0.0 4.2e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.16 AET41638.1 - 0.00015 20.8 0.0 0.00024 20.1 0.0 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein Met_gamma_lyase PF06838.11 AET41638.1 - 0.021 13.4 0.4 0.13 10.8 0.4 1.9 1 1 0 1 1 1 0 Methionine gamma-lyase Aconitase PF00330.20 AET41639.1 - 1.6e-150 502.2 0.0 2e-150 501.9 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 AET41639.1 - 1.1e-46 158.3 0.0 2.3e-46 157.3 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain PI3_PI4_kinase PF00454.27 AET41640.1 - 2.8e-41 142.0 0.3 4.2e-38 131.6 0.0 3.8 3 1 0 3 3 3 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 AET41640.1 - 3.9e-27 94.8 0.8 7e-27 94.0 0.2 1.8 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) UQ_con PF00179.26 AET41642.1 - 6.8e-33 113.3 0.0 1e-32 112.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Polysacc_deac_1 PF01522.21 AET41644.1 - 1.1e-24 86.6 0.0 1.9e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase GRIP PF01465.20 AET41645.1 - 3.9e-13 49.1 0.2 9.4e-13 47.8 0.2 1.7 1 0 0 1 1 1 1 GRIP domain TMF_TATA_bd PF12325.8 AET41645.1 - 0.0037 17.5 10.7 0.0037 17.5 10.7 9.1 3 2 5 8 8 8 2 TATA element modulatory factor 1 TATA binding WXG100 PF06013.12 AET41645.1 - 0.0085 16.3 1.8 0.0085 16.3 1.8 5.8 4 3 1 5 5 5 1 Proteins of 100 residues with WXG SlyX PF04102.12 AET41645.1 - 0.012 16.2 0.6 0.012 16.2 0.6 10.7 4 4 8 12 12 12 0 SlyX T2SSF PF00482.23 AET41645.1 - 1 9.4 3.4 9.9 6.1 0.6 3.1 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F tRNA-synt_2 PF00152.20 AET41646.1 - 2.6e-80 269.8 0.7 4.4e-80 269.1 0.7 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AET41646.1 - 5.9e-06 26.2 0.1 1.3e-05 25.1 0.1 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 AET41646.1 - 0.1 12.1 1.0 2.2 7.7 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) zf-C2H2 PF00096.26 AET41647.1 - 5.4e-08 32.9 12.8 0.0014 19.0 4.9 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AET41647.1 - 0.00017 22.1 10.9 0.096 13.6 3.3 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 AET41647.1 - 0.00044 20.6 10.2 0.036 14.5 0.9 3.1 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 AET41647.1 - 0.00057 20.2 0.2 0.00057 20.2 0.2 3.3 4 0 0 4 4 4 1 Zinc-finger double domain FOXP-CC PF16159.5 AET41647.1 - 0.0014 19.3 0.1 0.0034 18.0 0.1 1.6 1 0 0 1 1 1 1 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 AET41647.1 - 0.012 15.9 5.6 0.94 9.8 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 AET41647.1 - 0.015 15.0 6.4 0.24 11.2 0.1 2.8 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.7 AET41647.1 - 3.7 7.9 6.5 11 6.4 1.1 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) CHCH PF06747.13 AET41648.1 - 0.0026 17.8 0.6 0.007 16.5 0.6 1.7 1 1 0 1 1 1 1 CHCH domain Pet191_N PF10203.9 AET41648.1 - 0.066 13.5 2.5 0.12 12.6 2.5 1.4 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 COX17 PF05051.13 AET41648.1 - 0.25 11.7 1.9 7.6 7.0 0.3 2.1 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) CX9C PF16860.5 AET41648.1 - 0.48 10.5 3.4 1.2 9.2 3.3 1.6 1 1 1 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, zf-C2H2 PF00096.26 AET41649.1 - 2.4e-09 37.1 8.1 1.9e-05 24.9 0.1 3.7 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AET41649.1 - 6.4e-07 29.7 6.9 0.00032 21.3 0.1 3.9 4 0 0 4 4 4 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AET41649.1 - 0.00039 20.7 0.9 0.00039 20.7 0.9 4.6 4 0 0 4 4 4 1 Zinc-finger double domain zf-met PF12874.7 AET41649.1 - 0.0011 19.3 5.3 0.016 15.6 0.0 3.2 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 AET41649.1 - 0.012 15.6 1.3 0.16 12.0 0.0 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AET41649.1 - 0.014 15.7 0.0 0.014 15.7 0.0 3.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 AET41649.1 - 0.061 13.3 4.7 4.4 7.4 4.7 2.7 1 1 0 1 1 1 0 BED zinc finger Pkinase PF00069.25 AET41650.1 - 1.3e-43 149.3 0.0 6.2e-43 147.1 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET41650.1 - 4.9e-19 68.6 0.0 1.2e-18 67.4 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Vir_act_alpha_C PF10400.9 AET41650.1 - 0.16 12.6 0.2 0.66 10.7 0.0 2.1 2 0 0 2 2 2 0 Virulence activator alpha C-term Nucleoporin_FG PF13634.6 AET41652.1 - 0.0011 19.7 92.7 0.0049 17.7 38.4 4.1 2 1 2 4 4 4 2 Nucleoporin FG repeat region DUF1664 PF07889.12 AET41652.1 - 0.2 11.7 2.4 4.2 7.4 0.5 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF4600 PF15372.6 AET41652.1 - 0.43 11.0 4.3 1.5 9.3 1.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4600) XRN_N PF03159.18 AET41653.1 - 3.8e-92 308.1 0.0 7.1e-92 307.2 0.0 1.5 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 AET41653.1 - 4.5e-83 279.7 10.6 4.5e-83 279.7 10.6 2.1 2 1 0 2 2 2 1 Xrn1 helical domain XRN1_D1 PF18332.1 AET41653.1 - 3.2e-56 190.2 1.2 4.2e-56 189.8 0.0 1.8 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D1 domain XRN1_D2_D3 PF18334.1 AET41653.1 - 2.1e-29 101.6 0.0 7.1e-29 99.9 0.0 2.0 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain SH3_12 PF18129.1 AET41653.1 - 1.5e-20 73.0 0.3 3.1e-20 72.0 0.3 1.6 1 0 0 1 1 1 1 Xrn1 SH3-like domain Xrn1_D3 PF18194.1 AET41653.1 - 2.4e-19 69.2 0.8 2e-18 66.2 0.1 2.9 2 0 0 2 2 2 1 Exoribonuclease 1 Domain-3 Bud13 PF09736.9 AET41654.1 - 8.8e-24 84.5 3.6 9e-20 71.5 0.3 2.6 2 0 0 2 2 2 2 Pre-mRNA-splicing factor of RES complex SAE2 PF08573.10 AET41655.1 - 0.41 11.8 2.9 1.8 9.7 0.9 2.7 2 1 0 2 2 2 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Mito_carr PF00153.27 AET41656.1 - 2.7e-71 235.6 0.2 3.8e-25 87.6 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein CDC73_N PF16050.5 AET41656.1 - 0.032 13.5 0.2 0.057 12.7 0.2 1.3 1 0 0 1 1 1 0 Paf1 complex subunit CDC73 N-terminal EF-hand_8 PF13833.6 AET41656.1 - 0.088 12.7 0.1 2.4 8.1 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain pair Serine_protease PF18405.1 AET41656.1 - 0.14 11.3 0.2 9.2 5.3 0.0 3.0 2 1 1 3 3 3 0 Gammaproteobacterial serine protease zf-C2H2 PF00096.26 AET41657.1 - 4.8e-10 39.3 11.6 9.3e-06 25.8 2.0 2.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AET41657.1 - 7.6e-08 32.6 6.8 0.0047 17.6 0.4 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 AET41657.1 - 1.3e-05 25.4 3.4 0.0093 16.3 0.2 2.8 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 AET41657.1 - 1.4e-05 25.3 9.3 0.2 12.1 0.5 3.7 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_6 PF13912.6 AET41657.1 - 7e-05 22.7 5.6 0.0094 15.9 0.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 AET41657.1 - 0.035 13.9 3.5 1.6 8.6 0.4 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_9 PF16293.5 AET41657.1 - 0.044 13.6 0.5 1 9.3 0.0 2.2 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) Zn_ribbon_SprT PF17283.2 AET41657.1 - 0.055 13.4 0.9 0.15 12.0 0.6 1.9 1 1 1 2 2 2 0 SprT-like zinc ribbon domain FOXP-CC PF16159.5 AET41657.1 - 0.088 13.5 0.5 0.22 12.2 0.0 1.8 2 0 0 2 2 2 0 FOXP coiled-coil domain zf-Di19 PF05605.12 AET41657.1 - 0.16 12.3 2.6 0.34 11.2 2.6 1.6 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 AET41658.1 - 6.3e-08 32.6 18.7 0.00011 22.4 3.6 2.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AET41658.1 - 2.9e-06 27.4 10.8 5.8e-05 23.3 1.1 3.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 AET41658.1 - 1.3e-05 25.6 16.1 0.0041 17.8 2.3 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 AET41658.1 - 0.0072 16.7 1.3 0.0072 16.7 1.3 3.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type C1_4 PF07975.12 AET41658.1 - 0.008 16.4 2.8 0.029 14.6 2.8 2.0 1 0 0 1 1 1 1 TFIIH C1-like domain zf-C2H2_6 PF13912.6 AET41658.1 - 0.027 14.5 6.9 0.036 14.1 1.3 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Peptidase_S15 PF02129.18 AET41658.1 - 0.083 12.5 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DUF3740 PF12548.8 AET41658.1 - 0.13 12.7 5.7 0.2 12.1 5.7 1.2 1 0 0 1 1 1 0 Sulfatase protein zf-C2H2_3rep PF18868.1 AET41658.1 - 0.15 12.8 7.7 0.26 12.0 1.4 2.3 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2 PF00096.26 AET41659.1 - 3.6e-06 27.1 8.8 0.0028 18.0 0.5 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AET41659.1 - 0.00028 21.2 12.3 0.0079 16.6 0.4 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 AET41659.1 - 0.00053 20.6 7.4 0.073 13.9 0.3 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger Zn-C2H2_12 PF18112.1 AET41659.1 - 0.01 16.3 0.2 0.031 14.8 0.2 1.8 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain zf-met PF12874.7 AET41659.1 - 0.19 12.1 2.5 2.2 8.8 0.3 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type FMN_red PF03358.15 AET41660.1 - 4.7e-07 29.7 0.0 6.1e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 AET41660.1 - 0.084 12.6 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Flavodoxin-like fold MRG PF05712.13 AET41661.1 - 1.5e-40 138.7 0.0 2.5e-40 137.9 0.0 1.3 2 0 0 2 2 2 1 MRG Tudor-knot PF11717.8 AET41661.1 - 1e-05 25.3 0.8 2e-05 24.4 0.8 1.5 1 1 0 1 1 1 1 RNA binding activity-knot of a chromodomain Pkinase PF00069.25 AET41662.1 - 1.7e-19 70.2 0.0 1.9e-18 66.8 0.0 2.2 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET41662.1 - 6.1e-09 35.5 0.0 9.1e-09 35.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AET41662.1 - 2.1e-06 26.8 1.9 3.3e-06 26.2 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 AET41662.1 - 0.084 12.8 0.0 8.7 6.2 0.0 2.5 1 1 1 2 2 2 0 Phosphotransferase enzyme family TFIIA PF03153.13 AET41662.1 - 6.5 6.6 16.9 9.2 6.1 16.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1997 PF09366.10 AET41663.1 - 0.15 12.2 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1997) WD40 PF00400.32 AET41663.1 - 0.36 11.8 5.2 0.24 12.3 0.7 3.1 4 0 0 4 4 4 0 WD domain, G-beta repeat HECT PF00632.25 AET41664.1 - 9.6e-94 314.3 0.0 1.3e-93 313.9 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 AET41664.1 - 4.1e-34 116.3 23.8 2.9e-12 46.4 1.9 4.0 4 0 0 4 4 4 3 WW domain C2 PF00168.30 AET41664.1 - 6.7e-19 68.1 0.1 2.7e-18 66.1 0.1 2.1 2 0 0 2 2 2 1 C2 domain PUF PF00806.19 AET41665.1 - 5.8e-54 176.9 31.6 2.1e-08 33.4 0.1 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Ribosomal_S8e PF01201.22 AET41666.1 - 1.5e-46 157.9 0.1 3.1e-46 157.0 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein S8e DUF3746 PF12562.8 AET41666.1 - 0.11 12.4 0.2 0.28 11.1 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3746) Sas10_Utp3 PF04000.15 AET41667.1 - 1.3e-09 38.6 0.7 4.4e-09 36.8 0.7 2.0 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Vfa1 PF08432.10 AET41668.1 - 1.4e-34 120.0 3.7 1.6e-34 119.8 3.7 1.1 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 Enterotoxin_ST PF02048.16 AET41668.1 - 0.091 13.2 0.3 0.27 11.7 0.3 1.8 1 0 0 1 1 1 0 Heat-stable enterotoxin ST V-set_2 PF15910.5 AET41668.1 - 0.18 11.9 3.1 0.32 11.1 0.3 2.1 2 0 0 2 2 2 0 ICOS V-set domain Pkinase PF00069.25 AET41669.1 - 1.4e-55 188.5 0.0 4.3e-55 186.9 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET41669.1 - 4.3e-27 95.0 0.1 1.2e-25 90.3 0.1 2.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AET41669.1 - 0.00062 18.6 0.0 0.0013 17.6 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 AET41669.1 - 0.0018 17.7 0.1 0.24 10.7 0.0 3.1 2 1 0 2 2 2 1 Kinase-like DUF3543 PF12063.8 AET41670.1 - 4.7e-88 294.8 0.1 4.7e-88 294.8 0.1 4.0 2 1 1 3 3 3 1 Domain of unknown function (DUF3543) Pkinase PF00069.25 AET41670.1 - 1.2e-56 192.0 0.0 1.2e-56 192.0 0.0 3.1 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AET41670.1 - 1.1e-42 146.2 0.0 1.1e-42 146.2 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase Dapper PF15268.6 AET41670.1 - 0.04 12.8 63.8 0.059 12.2 63.8 1.2 1 0 0 1 1 1 0 Dapper Pkinase_fungal PF17667.1 AET41670.1 - 1.5 7.5 0.0 1.5 7.5 0.0 3.9 3 1 0 3 3 3 0 Fungal protein kinase ArfGap PF01412.18 AET41671.1 - 7e-29 100.3 0.7 7e-29 100.3 0.7 3.0 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf GTSE1_N PF15259.6 AET41671.1 - 0.003 17.7 3.4 0.003 17.7 3.4 2.6 2 0 0 2 2 2 1 G-2 and S-phase expressed 1 UBA PF00627.31 AET41671.1 - 0.015 15.2 0.0 0.015 15.2 0.0 2.1 2 0 0 2 2 2 0 UBA/TS-N domain HNH_2 PF13391.6 AET41671.1 - 0.15 12.2 0.0 0.47 10.6 0.0 1.8 1 0 0 1 1 1 0 HNH endonuclease HypA PF01155.19 AET41671.1 - 2 8.5 4.9 0.34 11.0 0.6 1.9 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Mnd1 PF03962.15 AET41672.1 - 8.1e-26 90.1 0.3 8.1e-26 90.1 0.3 2.0 2 0 0 2 2 1 1 Mnd1 HTH domain Wtap PF17098.5 AET41672.1 - 4e-05 23.6 6.4 8.4e-05 22.5 6.4 1.4 1 0 0 1 1 1 1 WTAP/Mum2p family PHM7_cyt PF14703.6 AET41672.1 - 0.012 15.9 11.7 0.013 15.7 1.4 2.2 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Nsp1_C PF05064.13 AET41672.1 - 0.013 15.3 1.6 0.013 15.3 1.6 2.3 2 0 0 2 2 2 0 Nsp1-like C-terminal region DUF4407 PF14362.6 AET41672.1 - 0.024 14.0 2.5 0.03 13.7 2.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HIP1_clath_bdg PF16515.5 AET41672.1 - 0.06 13.9 9.4 1.3 9.6 2.6 2.4 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fib_alpha PF08702.10 AET41672.1 - 0.062 13.5 7.0 0.51 10.5 0.5 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.12 AET41672.1 - 0.079 13.4 5.1 0.9 10.0 0.5 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Tho2 PF11262.8 AET41672.1 - 0.088 12.0 7.6 0.13 11.5 7.6 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 GAS PF13851.6 AET41672.1 - 0.17 11.2 17.9 2.2 7.6 17.9 2.1 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding IL11 PF07400.11 AET41672.1 - 0.18 11.5 2.1 0.2 11.3 0.2 1.9 2 0 0 2 2 2 0 Interleukin 11 OmpH PF03938.14 AET41672.1 - 0.19 12.1 16.8 0.51 10.7 16.8 1.7 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) KASH_CCD PF14662.6 AET41672.1 - 0.21 11.4 11.5 0.48 10.2 11.5 1.6 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Succ_DH_flav_C PF02910.20 AET41672.1 - 0.33 11.0 4.4 2.3 8.2 0.3 2.3 2 0 0 2 2 2 0 Fumarate reductase flavoprotein C-term Uso1_p115_C PF04871.13 AET41672.1 - 0.39 11.1 10.9 2.9 8.3 0.7 2.2 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Rho_Binding PF08912.11 AET41672.1 - 0.4 11.5 12.7 0.94 10.3 3.8 2.6 2 1 0 2 2 2 0 Rho Binding Jnk-SapK_ap_N PF09744.9 AET41672.1 - 0.62 10.3 12.7 1.4 9.1 12.4 1.7 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Occludin_ELL PF07303.13 AET41672.1 - 1.2 9.9 13.5 41 5.0 13.5 2.4 1 1 0 1 1 1 0 Occludin homology domain KxDL PF10241.9 AET41672.1 - 1.3 9.4 12.4 2.2 8.6 3.6 2.7 2 1 0 2 2 2 0 Uncharacterized conserved protein BLOC1_2 PF10046.9 AET41672.1 - 1.5 9.2 14.6 7.9 6.9 2.0 2.8 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tropomyosin_1 PF12718.7 AET41672.1 - 2.2 8.4 15.7 14 5.9 15.4 2.0 1 1 0 1 1 1 0 Tropomyosin like COG2 PF06148.11 AET41672.1 - 4.7 7.3 9.1 11 6.1 1.5 2.3 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF16 PF01519.16 AET41672.1 - 4.9 7.7 16.9 3.8 8.0 4.2 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 ZapB PF06005.12 AET41672.1 - 5 7.6 14.2 3.7 8.1 1.4 2.8 2 1 0 2 2 2 0 Cell division protein ZapB bZIP_1 PF00170.21 AET41672.1 - 6.2 7.0 11.0 8.5 6.6 1.4 3.3 3 0 0 3 3 3 0 bZIP transcription factor UPF0242 PF06785.11 AET41672.1 - 9.9 6.2 16.1 32 4.5 16.1 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus zf-C2H2 PF00096.26 AET41673.1 - 6.7e-11 42.0 13.5 5.4e-06 26.6 0.5 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AET41673.1 - 2.5e-08 34.0 12.7 1.5e-06 28.4 1.2 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 AET41673.1 - 3.1e-08 33.8 12.1 0.00025 21.6 0.2 3.1 3 0 0 3 3 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AET41673.1 - 9.1e-07 29.0 3.8 0.015 15.5 0.3 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 AET41673.1 - 7.3e-06 26.2 3.7 0.11 13.0 0.5 3.0 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-Di19 PF05605.12 AET41673.1 - 0.00053 20.2 1.3 0.0011 19.3 1.3 1.5 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 AET41673.1 - 0.0017 18.3 0.4 0.0017 18.3 0.4 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-BED PF02892.15 AET41673.1 - 0.036 14.1 5.3 0.53 10.3 2.2 2.5 1 1 1 2 2 2 0 BED zinc finger zf-H2C2_5 PF13909.6 AET41673.1 - 0.2 11.5 5.9 0.92 9.3 0.5 2.7 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Caldesmon PF02029.15 AET41673.1 - 1.5 7.5 13.3 2.4 6.8 13.3 1.2 1 0 0 1 1 1 0 Caldesmon zf-C2HC_2 PF13913.6 AET41673.1 - 3.7 7.6 10.7 4.6 7.3 0.1 2.7 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Zn_clus PF00172.18 AET41674.1 - 1.6e-08 34.5 9.8 1.6e-08 34.5 9.8 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 AET41674.1 - 5.9e-06 25.5 0.8 1.3e-05 24.4 0.8 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Cys_Met_Meta_PP PF01053.20 AET41675.1 - 7.2e-120 400.0 0.0 8.3e-120 399.8 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Prp19 PF08606.11 AET41676.1 - 2.2e-30 104.4 1.1 3.8e-30 103.7 1.1 1.4 1 0 0 1 1 1 1 Prp19/Pso4-like U-box PF04564.15 AET41676.1 - 0.0011 19.0 0.0 0.003 17.7 0.0 1.7 1 0 0 1 1 1 1 U-box domain GIT_CC PF16559.5 AET41676.1 - 0.11 12.4 1.3 0.29 11.0 0.4 2.1 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor ANAPC4_WD40 PF12894.7 AET41676.1 - 0.13 12.6 0.0 0.83 10.0 0.0 2.3 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain ENTH PF01417.20 AET41677.1 - 1.9e-29 102.2 0.6 2.8e-29 101.7 0.6 1.2 1 0 0 1 1 1 1 ENTH domain SAP18 PF06487.12 AET41677.1 - 0.031 14.5 0.0 0.071 13.3 0.0 1.7 1 0 0 1 1 1 0 Sin3 associated polypeptide p18 (SAP18) Stk19 PF10494.9 AET41677.1 - 0.084 12.5 0.1 0.11 12.2 0.1 1.2 1 0 0 1 1 1 0 Serine-threonine protein kinase 19 ubiquitin PF00240.23 AET41678.1 - 9.6e-69 227.1 6.2 7.8e-34 115.3 0.6 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 AET41678.1 - 3.9e-33 113.1 6.5 4.8e-16 58.3 0.7 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 AET41678.1 - 1.5e-12 47.8 1.8 0.00011 22.5 0.1 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain Ubiquitin_5 PF18037.1 AET41678.1 - 1.9e-08 34.6 0.4 0.0076 16.6 0.0 2.1 1 1 1 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 AET41678.1 - 2.3e-08 33.8 0.3 0.0077 16.1 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 AET41678.1 - 2e-07 31.1 0.4 0.034 14.3 0.1 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 AET41678.1 - 2.5e-06 28.0 0.1 0.11 13.1 0.0 2.2 1 1 0 2 2 2 2 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 AET41678.1 - 1.4e-05 25.0 0.1 0.16 11.8 0.0 2.1 1 1 1 2 2 2 2 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 AET41678.1 - 3e-05 24.0 8.0 5.8 7.0 0.2 4.0 4 0 0 4 4 4 4 Ubiquitin-like domain DUF3861 PF12977.7 AET41678.1 - 0.0044 17.1 0.2 3.2 8.0 0.0 2.2 1 1 1 2 2 2 2 Domain of Unknown Function with PDB structure (DUF3861) ACT_5 PF13710.6 AET41678.1 - 0.0055 16.5 0.5 3.8 7.4 0.0 2.4 2 0 0 2 2 2 2 ACT domain DUF2870 PF11069.8 AET41678.1 - 0.015 15.7 0.0 11 6.5 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) YcgR_2 PF12945.7 AET41678.1 - 0.027 14.6 0.4 9.7 6.4 0.1 2.3 2 0 0 2 2 2 0 Flagellar protein YcgR Big_7 PF17957.1 AET41678.1 - 0.046 14.5 0.0 17 6.3 0.0 2.2 2 0 0 2 2 2 0 Bacterial Ig domain UN_NPL4 PF11543.8 AET41678.1 - 0.069 13.6 0.2 16 6.0 0.0 2.3 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 DUF969 PF06149.12 AET41678.1 - 0.16 11.4 0.0 6.9 6.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF969) Tash_PEST PF07708.11 AET41678.1 - 0.18 12.0 9.6 2.7 8.2 1.5 2.3 2 0 0 2 2 2 0 Tash protein PEST motif FERM_f0 PF16511.5 AET41678.1 - 0.2 12.0 1.3 37 4.7 0.1 3.2 2 2 0 2 2 2 0 N-terminal or F0 domain of Talin-head FERM Plexin_cytopl PF08337.12 AET41678.1 - 0.46 9.1 5.4 4.8 5.7 0.4 2.9 2 1 0 3 3 3 0 Plexin cytoplasmic RasGAP domain SHR-BD PF06650.12 AET41679.1 - 7.9e-94 314.0 4.7 8.9e-90 300.7 0.0 4.4 5 0 0 5 5 5 2 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_mid_rpt PF16910.5 AET41679.1 - 2.1e-79 266.3 14.6 3.7e-79 265.5 0.2 5.9 6 0 0 6 6 6 1 Repeating coiled region of VPS13 VPS13_C PF16909.5 AET41679.1 - 1.2e-75 253.2 6.8 7.4e-70 234.3 1.1 3.6 3 0 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 AET41679.1 - 4.2e-74 249.3 9.6 5.6e-73 245.6 2.0 4.1 4 0 0 4 4 4 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 AET41679.1 - 1.2e-36 125.3 0.2 6.3e-36 123.0 0.0 2.4 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 AET41679.1 - 0.066 13.6 0.1 0.17 12.3 0.1 1.6 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain Rio2_N PF09202.11 AET41679.1 - 0.1 12.8 0.0 0.45 10.8 0.0 2.1 1 0 0 1 1 1 0 Rio2, N-terminal Fer2_3 PF13085.6 AET41680.1 - 7.6e-35 119.2 0.1 1.2e-34 118.5 0.1 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 AET41680.1 - 1.3e-09 38.4 7.9 1.3e-09 38.4 7.9 2.4 2 1 1 3 3 3 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 AET41680.1 - 4.6e-08 33.4 9.7 4.6e-08 33.4 9.7 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 AET41680.1 - 1.2e-07 31.7 4.9 1.2e-07 31.7 4.9 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 AET41680.1 - 0.0036 17.2 1.3 0.0036 17.2 1.3 2.4 2 1 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.7 AET41680.1 - 0.019 15.5 9.7 0.019 15.5 9.7 2.7 2 2 0 2 2 2 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 AET41680.1 - 0.023 14.9 9.3 0.023 14.9 9.3 2.6 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 AET41680.1 - 0.16 12.1 6.5 0.45 10.7 0.1 2.5 3 0 0 3 3 3 0 4Fe-4S dicluster domain Autophagy_act_C PF03987.15 AET41681.1 - 5.5e-07 30.1 0.0 1.6e-06 28.6 0.0 1.8 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain VID27_PH PF17747.1 AET41681.1 - 0.089 13.1 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 VID27 PH-like domain V-SNARE_C PF12352.8 AET41682.1 - 1.1e-17 64.1 1.0 1.1e-17 64.1 1.0 2.5 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus MCU PF04678.13 AET41682.1 - 0.0056 16.8 3.1 0.21 11.7 3.1 2.1 1 1 0 1 1 1 1 Mitochondrial calcium uniporter DUF4854 PF16146.5 AET41682.1 - 0.11 12.8 1.2 11 6.4 0.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4854) Jnk-SapK_ap_N PF09744.9 AET41682.1 - 0.87 9.8 11.8 0.041 14.1 1.8 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.6 AET41682.1 - 2.3 7.5 6.8 3 7.1 6.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) PMC2NT PF08066.12 AET41682.1 - 3.6 8.3 6.8 2.2 9.0 0.3 2.4 2 1 0 2 2 2 0 PMC2NT (NUC016) domain Exonuc_VII_L PF02601.15 AET41682.1 - 5.7 6.4 11.5 11 5.5 11.5 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit UPF0242 PF06785.11 AET41682.1 - 7.3 6.6 13.6 0.37 10.9 3.5 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus MIP PF00230.20 AET41683.1 - 2e-58 197.8 1.4 2.7e-58 197.4 1.4 1.2 1 0 0 1 1 1 1 Major intrinsic protein DUF4944 PF16302.5 AET41683.1 - 0.041 13.9 0.0 0.21 11.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4944) FGGY_C PF02782.16 AET41684.1 - 3e-70 236.0 0.3 8.8e-70 234.5 0.1 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 AET41684.1 - 4.5e-50 170.5 0.1 2e-42 145.4 0.0 2.5 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 AET41684.1 - 0.0099 15.4 0.2 0.13 11.7 0.1 2.5 3 0 0 3 3 3 1 BadF/BadG/BcrA/BcrD ATPase family Ribosomal_L7Ae PF01248.26 AET41685.1 - 1.3e-23 82.5 0.5 2.2e-23 81.8 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RRM_1 PF00076.22 AET41686.1 - 1.2e-16 60.3 3.8 1.6e-09 37.4 0.4 3.4 2 2 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ABC_tran PF00005.27 AET41687.1 - 1.3e-57 194.2 0.0 5.5e-34 117.6 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 AET41687.1 - 1.7e-53 182.0 35.9 6.5e-34 117.8 16.7 3.3 3 0 0 3 3 3 3 ABC transporter transmembrane region AAA_23 PF13476.6 AET41687.1 - 4.2e-10 40.5 1.9 7.2e-05 23.4 0.5 2.5 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.19 AET41687.1 - 1e-08 34.9 4.7 0.00096 18.6 0.7 4.1 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 AET41687.1 - 3.1e-08 33.8 1.6 0.021 14.6 0.1 3.7 3 1 0 4 4 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AET41687.1 - 8.2e-07 28.7 1.5 0.0021 17.8 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AET41687.1 - 7.6e-06 25.9 0.8 0.098 12.6 0.2 2.7 2 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 AET41687.1 - 2.3e-05 24.4 0.1 0.01 15.9 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_15 PF13175.6 AET41687.1 - 7.1e-05 22.7 5.4 0.08 12.6 0.1 2.5 3 0 0 3 3 2 2 AAA ATPase domain AAA_16 PF13191.6 AET41687.1 - 0.00011 22.7 0.1 0.27 11.6 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain T2SSE PF00437.20 AET41687.1 - 0.00023 20.3 0.3 0.036 13.1 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_22 PF13401.6 AET41687.1 - 0.00051 20.3 0.4 1.2 9.4 0.1 3.2 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 AET41687.1 - 0.00085 18.9 0.2 0.58 9.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 AET41687.1 - 0.0023 17.7 0.4 0.094 12.4 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AET41687.1 - 0.0034 17.1 0.0 3.4 7.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 AET41687.1 - 0.013 15.6 2.5 0.51 10.4 0.0 3.0 3 0 0 3 3 3 0 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 AET41687.1 - 0.019 14.3 0.5 4.6 6.5 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.19 AET41687.1 - 0.026 14.1 0.8 0.68 9.5 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.12 AET41687.1 - 0.031 13.6 0.0 2.4 7.4 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_33 PF13671.6 AET41687.1 - 0.036 14.2 0.1 6.3 7.0 0.1 2.9 3 0 0 3 3 3 0 AAA domain ATP_bind_1 PF03029.17 AET41687.1 - 0.051 13.4 0.7 21 4.8 0.0 3.5 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 AET41687.1 - 0.075 12.6 0.0 2 7.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 AET41687.1 - 0.094 11.6 0.0 5.8 5.7 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain ResIII PF04851.15 AET41687.1 - 0.11 12.5 0.0 7.2 6.6 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Roc PF08477.13 AET41687.1 - 0.11 12.7 1.2 18 5.6 0.1 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 AET41687.1 - 0.13 12.3 0.2 22 5.1 0.0 2.6 2 0 0 2 2 2 0 Dynamin family ATPase_2 PF01637.18 AET41687.1 - 0.13 12.2 0.0 0.66 9.9 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Adeno_IVa2 PF02456.15 AET41687.1 - 0.14 10.9 0.1 1.7 7.4 0.0 2.1 2 0 0 2 2 2 0 Adenovirus IVa2 protein NB-ARC PF00931.22 AET41687.1 - 0.16 11.2 0.5 1.1 8.4 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain AAA_5 PF07728.14 AET41687.1 - 0.17 11.9 0.1 16 5.5 0.0 2.8 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) Pox_A32 PF04665.12 AET41687.1 - 0.17 11.3 0.7 5.9 6.3 0.1 2.8 3 0 0 3 3 3 0 Poxvirus A32 protein AAA_14 PF13173.6 AET41687.1 - 0.18 11.8 0.2 30 4.7 0.0 3.4 3 0 0 3 3 3 0 AAA domain AA_permease_2 PF13520.6 AET41688.1 - 2.6e-61 207.8 40.4 3.3e-61 207.4 40.4 1.1 1 0 0 1 1 1 1 Amino acid permease UPF0093 PF03653.13 AET41688.1 - 0.53 10.5 4.5 7.3 6.8 0.1 3.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0093) DUF4811 PF16069.5 AET41689.1 - 0.0049 16.8 0.1 0.012 15.5 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4811) DUF2497 PF10691.9 AET41690.1 - 0.026 14.9 0.0 0.044 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2497) Cofilin_ADF PF00241.20 AET41691.1 - 3.8e-40 136.5 0.2 4.3e-40 136.3 0.2 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein HTH_Tnp_Tc5 PF03221.16 AET41692.1 - 6.7e-14 51.7 1.2 1.8e-13 50.3 0.2 2.2 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DUF4817 PF16087.5 AET41692.1 - 0.031 14.1 0.1 0.11 12.3 0.1 2.0 1 0 0 1 1 1 0 Helix-turn-helix domain (DUF4817) HTH_32 PF13565.6 AET41692.1 - 0.049 14.2 0.0 0.12 13.0 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain CENP-B_N PF04218.13 AET41692.1 - 0.081 12.6 0.1 0.18 11.4 0.1 1.7 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Phosphoesterase PF04185.14 AET41693.1 - 3.3e-39 135.1 1.7 3.5e-37 128.4 1.5 2.8 1 1 1 2 2 2 2 Phosphoesterase family Cu-oxidase PF00394.22 AET41694.1 - 1.1e-34 119.9 0.3 2.8e-32 112.0 0.1 2.6 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 AET41694.1 - 3.8e-32 110.9 18.8 4.1e-32 110.8 0.5 3.7 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 AET41694.1 - 9.4e-31 106.3 3.3 9.9e-31 106.2 0.3 2.6 4 0 0 4 4 4 1 Multicopper oxidase # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Eremothecium_cymbalariae_DBVPG7215-ASM23536v1/GCA_000235365.1_ASM23536v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Eremothecium_cymbalariae_DBVPG7215-ASM23536v1/GCA_000235365.1_ASM23536v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Eremothecium_cymbalariae_DBVPG7215-ASM23536v1/GCA_000235365.1_ASM23536v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Eremothecium_cymbalariae_DBVPG7215-ASM23536v1/GCA_000235365.1_ASM23536v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 18:55:49 2019 # [ok]