# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- DUF1689 PF07954.6 CCF31719.1 - 0.11 12.3 0.1 0.27 11.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1689) BBE PF08031.7 CCF31720.1 - 3.3e-07 30.1 0.2 1e-06 28.5 0.1 1.8 1 0 0 1 1 1 1 Berberine and berberine like CDP-OH_P_transf PF01066.16 CCF31721.1 - 1.3e-17 63.9 2.9 1.6e-17 63.6 1.5 1.4 1 1 0 1 1 1 1 CDP-alcohol phosphatidyltransferase Amidohydro_5 PF13594.1 CCF31723.1 - 7.1e-15 54.5 3.8 9.5e-15 54.1 0.2 2.7 3 1 0 3 3 3 1 Amidohydrolase Amidohydro_1 PF01979.15 CCF31723.1 - 3.1e-07 30.3 0.1 3.6e-07 30.1 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 CCF31723.1 - 0.002 18.2 0.1 0.003 17.6 0.1 1.4 1 0 0 1 1 1 1 Amidohydrolase T2SI PF02501.12 CCF31725.1 - 0.049 13.5 0.3 0.085 12.8 0.2 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein I CrtC PF07143.6 CCF31727.1 - 1.4e-17 63.9 1.4 2e-16 60.1 1.0 2.0 1 1 0 1 1 1 1 Hydroxyneurosporene synthase (CrtC) Chitin_bind_3 PF03067.10 CCF31728.1 - 5.2e-14 52.9 0.6 6.4e-14 52.6 0.4 1.1 1 0 0 1 1 1 1 Chitin binding domain GIY-YIG PF01541.19 CCF31730.1 - 4.8e-08 33.2 0.0 8.7e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 GIY-YIG catalytic domain zf-HC5HC2H PF13771.1 CCF31730.1 - 0.016 15.3 2.9 0.028 14.5 2.0 1.3 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.1 CCF31730.1 - 0.027 14.4 2.5 0.046 13.7 1.7 1.3 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-C2HC PF01530.13 CCF31730.1 - 0.055 13.2 1.2 0.055 13.2 0.9 1.8 2 0 0 2 2 2 0 Zinc finger, C2HC type T5orf172 PF10544.4 CCF31730.1 - 0.055 13.8 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 T5orf172 domain FANCL_C PF11793.3 CCF31730.1 - 0.35 10.8 4.8 0.87 9.5 3.3 1.6 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_2 PF13639.1 CCF31730.1 - 0.36 10.7 8.4 0.53 10.1 5.4 1.6 2 0 0 2 2 2 0 Ring finger domain PHD PF00628.24 CCF31730.1 - 0.56 9.9 7.6 0.85 9.3 5.3 1.3 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.1 CCF31730.1 - 0.56 9.9 4.8 0.93 9.2 1.7 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING-like PF08746.6 CCF31730.1 - 1.1 9.2 8.0 5.1 7.1 5.5 2.0 1 1 0 1 1 1 0 RING-like domain zf-C3HC4_2 PF13923.1 CCF31730.1 - 2.1 8.4 5.2 5.2 7.1 3.6 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Grp1_Fun34_YaaH PF01184.14 CCF31733.1 - 1.7e-29 102.6 0.7 2.3e-29 102.1 0.5 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family SCO1-SenC PF02630.9 CCF31735.1 - 5.8e-48 162.7 0.0 7.7e-48 162.3 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.16 CCF31735.1 - 1.8e-07 30.8 0.0 2.9e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.1 CCF31735.1 - 0.00013 21.9 0.0 0.00028 20.9 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.5 CCF31735.1 - 0.026 14.0 0.0 0.038 13.5 0.0 1.2 1 0 0 1 1 1 0 Redoxin Glyco_hydro_16 PF00722.16 CCF31738.1 - 7.2e-17 61.2 0.1 2.8e-16 59.3 0.1 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.10 CCF31738.1 - 1.1e-05 23.8 1.1 0.032 12.4 0.4 2.1 1 1 1 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) DUF2401 PF10287.4 CCF31738.1 - 0.041 13.3 0.4 0.1 12.0 0.3 1.7 1 1 0 1 1 1 0 Putative TOS1-like glycosyl hydrolase (DUF2401) Abhydrolase_9_N PF15420.1 CCF31739.1 - 6.1 6.5 6.4 11 5.6 4.5 1.4 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus NAD_binding_10 PF13460.1 CCF31741.1 - 4.5e-06 26.7 0.0 4.7e-06 26.7 0.0 1.0 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF31741.1 - 0.015 14.5 0.0 0.015 14.5 0.0 1.0 1 0 0 1 1 1 0 NmrA-like family HSP20 PF00011.16 CCF31743.1 - 5.6e-17 61.4 0.0 2.6e-11 43.2 0.0 2.3 2 0 0 2 2 2 2 Hsp20/alpha crystallin family LysM PF01476.15 CCF31744.1 - 8.1e-14 51.2 0.0 5.5e-07 29.3 0.0 2.4 2 0 0 2 2 2 2 LysM domain Glyco_hydro_71 PF03659.9 CCF31745.1 - 1.3e-52 178.5 0.1 2.6e-47 161.1 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolase family 71 Sugar_tr PF00083.19 CCF31746.1 - 5.5e-16 58.1 0.2 6.5e-16 57.9 0.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter SDH_beta PF03315.10 CCF31747.1 - 7.1e-36 123.6 0.0 1.1e-35 122.9 0.0 1.3 1 0 0 1 1 1 1 Serine dehydratase beta chain DUF1968 PF09291.5 CCF31749.1 - 0.062 13.1 0.0 0.091 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1968) YpzI PF14140.1 CCF31750.1 - 3.4 7.2 6.4 6.7 6.2 0.2 2.4 2 0 0 2 2 2 0 YpzI-like protein Ank_2 PF12796.2 CCF31751.1 - 5.9e-29 100.2 0.4 8.3e-16 58.1 0.1 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 CCF31751.1 - 8.1e-22 75.8 0.6 4.6e-07 29.3 0.0 3.2 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 CCF31751.1 - 2.5e-16 59.7 0.0 5.3e-08 33.1 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF31751.1 - 1.8e-15 55.4 0.1 0.00014 21.7 0.0 3.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 CCF31751.1 - 1.7e-12 47.1 0.1 0.0038 17.4 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Gas_vesicle PF00741.13 CCF31751.1 - 0.0073 16.1 1.0 5.1 7.0 0.0 2.6 3 0 0 3 3 3 2 Gas vesicle protein GCV_T PF01571.16 CCF31751.1 - 0.1 11.9 0.2 0.64 9.3 0.0 2.0 1 1 1 2 2 2 0 Aminomethyltransferase folate-binding domain Glyco_transf_28 PF03033.15 CCF31752.1 - 9.1e-17 61.1 0.0 2.2e-16 59.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.13 CCF31752.1 - 0.0001 21.0 0.0 0.00028 19.5 0.0 1.7 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 CCF31752.1 - 0.028 14.0 0.0 0.079 12.6 0.0 1.7 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain MIP-T3 PF10243.4 CCF31752.1 - 9.5 4.5 33.3 0.026 13.0 5.5 2.2 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 Kinetochor_Ybp2 PF08568.5 CCF31753.1 - 1.2e-95 321.1 0.0 1.5e-95 320.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin Pex24p PF06398.6 CCF31753.1 - 0.00028 19.8 0.0 0.00045 19.1 0.0 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF3704 PF12488.3 CCF31753.1 - 0.076 12.6 0.2 0.18 11.4 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) FANCI_S3 PF14677.1 CCF31753.1 - 0.086 12.2 0.0 0.22 10.8 0.0 1.7 1 1 0 1 1 1 0 FANCI solenoid 3 PBP1_TM PF14812.1 CCF31756.1 - 0.0018 18.5 0.4 0.0031 17.7 0.3 1.3 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal ATP-synt_D PF01813.12 CCF31756.1 - 0.045 13.3 0.0 0.064 12.8 0.0 1.3 1 0 0 1 1 1 0 ATP synthase subunit D 2OG-FeII_Oxy PF03171.15 CCF31757.1 - 2.6e-22 78.9 0.0 6.5e-22 77.6 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 CCF31757.1 - 7.8e-17 61.8 0.0 1.3e-16 61.1 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal DUF167 PF02594.11 CCF31758.1 - 2.9e-18 65.5 0.1 4.5e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 Ldh_1_N PF00056.18 CCF31758.1 - 0.097 12.4 0.1 0.11 12.2 0.1 1.3 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Glyco_hydro_28 PF00295.12 CCF31759.1 - 3.5e-40 137.9 6.0 5.6e-39 133.9 1.0 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 28 Beta_helix PF13229.1 CCF31759.1 - 0.96 9.1 17.0 0.067 12.9 3.3 2.8 1 1 1 2 2 2 0 Right handed beta helix region WWbp PF10349.4 CCF31761.1 - 1.2e-13 51.9 11.5 1.2e-13 51.9 8.0 2.2 2 2 0 2 2 2 1 WW-domain ligand protein Vps36_ESCRT-II PF11605.3 CCF31761.1 - 0.012 15.3 0.0 0.041 13.6 0.0 1.8 1 1 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 SPX PF03105.14 CCF31761.1 - 0.09 12.5 5.7 0.14 11.9 3.9 1.3 1 0 0 1 1 1 0 SPX domain Pterin_4a PF01329.14 CCF31762.1 - 3.8e-17 61.8 0.3 5.1e-17 61.4 0.2 1.2 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase CPSF73-100_C PF11718.3 CCF31762.1 - 0.058 12.7 0.0 0.058 12.7 0.0 1.0 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Complex1_LYR PF05347.10 CCF31764.1 - 3.3e-09 36.3 0.2 6.9e-09 35.3 0.0 1.6 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 CCF31764.1 - 1.3e-06 28.5 0.3 2e-06 27.8 0.2 1.5 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_2 PF13233.1 CCF31764.1 - 8.8e-05 22.9 0.2 0.00013 22.4 0.1 1.4 1 1 0 1 1 1 1 Complex1_LYR-like DMPK_coil PF08826.5 CCF31765.1 - 0.031 14.1 1.4 7.2 6.5 0.3 2.7 1 1 2 3 3 3 0 DMPK coiled coil domain like FAD_binding_3 PF01494.14 CCF31766.1 - 3e-21 75.8 0.1 1e-20 74.1 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain ADC PF06314.6 CCF31766.1 - 9.3e-17 61.1 0.0 1.7e-16 60.3 0.0 1.4 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) DAO PF01266.19 CCF31766.1 - 1.4e-08 34.0 2.9 4.8e-06 25.7 0.9 2.3 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF31766.1 - 9.6e-08 31.9 0.3 3.4e-07 30.1 0.2 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF31766.1 - 7.7e-05 22.6 0.4 0.00018 21.4 0.2 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF31766.1 - 0.00047 19.1 1.4 0.0006 18.7 0.4 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.1 CCF31766.1 - 0.0014 18.7 0.1 0.0032 17.5 0.1 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF31766.1 - 0.0015 18.3 0.5 0.0055 16.4 0.4 1.9 1 1 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox PF00070.22 CCF31766.1 - 0.0019 18.5 0.4 0.0069 16.7 0.2 2.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CCF31766.1 - 0.012 14.5 0.7 0.019 13.8 0.5 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A HI0933_like PF03486.9 CCF31766.1 - 0.022 13.2 0.1 0.034 12.6 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein AlaDh_PNT_C PF01262.16 CCF31766.1 - 0.03 13.8 0.0 0.064 12.8 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.12 CCF31766.1 - 0.06 12.4 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Thi4 family 3HCDH_N PF02737.13 CCF31766.1 - 0.069 12.8 0.1 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.18 CCF31766.1 - 0.083 12.6 0.1 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_oxidored PF12831.2 CCF31766.1 - 0.11 11.5 0.2 0.25 10.3 0.2 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 CCF31766.1 - 0.21 10.4 0.4 0.64 8.8 0.3 1.8 1 1 0 1 1 1 0 Lycopene cyclase protein Cupin_2 PF07883.6 CCF31767.1 - 3.1e-07 29.7 0.0 4.8e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.7 CCF31767.1 - 0.0016 17.8 0.0 0.0028 17.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_1 PF00190.17 CCF31767.1 - 0.0039 16.6 0.0 0.0054 16.1 0.0 1.2 1 0 0 1 1 1 1 Cupin FYVE PF01363.16 CCF31769.1 - 6e-21 74.1 0.6 6e-21 74.1 0.4 2.8 3 0 0 3 3 3 1 FYVE zinc finger Rad50_zn_hook PF04423.9 CCF31769.1 - 0.012 15.0 1.8 0.028 13.8 0.2 2.1 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-DHHC PF01529.15 CCF31769.1 - 0.042 13.2 0.4 0.12 11.7 0.1 1.9 2 0 0 2 2 2 0 DHHC palmitoyltransferase FYVE_2 PF02318.11 CCF31769.1 - 0.17 11.8 5.5 0.13 12.1 1.5 2.2 2 0 0 2 2 2 0 FYVE-type zinc finger zf-piccolo PF05715.8 CCF31769.1 - 0.64 10.0 9.4 5.9 6.9 2.9 2.8 2 0 0 2 2 2 0 Piccolo Zn-finger Elf1 PF05129.8 CCF31769.1 - 7.3 6.3 10.5 0.37 10.5 1.3 2.8 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like KR PF08659.5 CCF31771.1 - 8.3e-65 217.8 0.3 1.1e-64 217.3 0.2 1.2 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 CCF31771.1 - 2.6e-50 170.6 0.5 3.5e-50 170.1 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase ADH_zinc_N_2 PF13602.1 CCF31771.1 - 3.2e-05 24.8 0.0 0.00036 21.4 0.0 2.4 3 0 0 3 3 3 1 Zinc-binding dehydrogenase Polysacc_synt_2 PF02719.10 CCF31771.1 - 0.12 11.2 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein MC1 PF05854.6 CCF31773.1 - 0.092 12.7 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Non-histone chromosomal protein MC1 DUF2076 PF09849.4 CCF31777.1 - 0.0012 18.9 0.2 0.0012 18.9 0.2 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) HSF_DNA-bind PF00447.12 CCF31778.1 - 3.1e-09 36.9 0.0 4.8e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 HSF-type DNA-binding p450 PF00067.17 CCF31780.1 - 1.3e-10 40.3 0.0 1.3e-10 40.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Guanylate_kin PF00625.16 CCF31781.1 - 2.9e-62 209.3 0.0 3.3e-62 209.2 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.1 CCF31781.1 - 4.8e-06 26.5 0.0 1.9e-05 24.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CCF31781.1 - 5.3e-06 26.7 0.0 1.6e-05 25.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF31781.1 - 0.00022 21.2 0.0 0.00035 20.6 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 CCF31781.1 - 0.00057 20.6 0.1 0.0011 19.7 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CCF31781.1 - 0.00072 19.7 0.0 0.0026 17.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 CCF31781.1 - 0.0034 16.5 0.0 0.0067 15.6 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_14 PF13173.1 CCF31781.1 - 0.022 14.6 0.0 0.19 11.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.1 CCF31781.1 - 0.036 14.0 0.2 0.46 10.4 0.1 2.3 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 CCF31781.1 - 0.04 14.1 0.1 0.1 12.9 0.1 1.8 1 1 0 1 1 1 0 ABC transporter Arch_ATPase PF01637.13 CCF31781.1 - 0.046 13.4 0.3 2.2 7.9 0.0 2.1 2 0 0 2 2 2 0 Archaeal ATPase DUF1895 PF08988.5 CCF31781.1 - 0.083 12.9 0.3 0.15 12.1 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1895) AAA_24 PF13479.1 CCF31781.1 - 0.12 11.8 0.1 0.29 10.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain DPBB_1 PF03330.13 CCF31782.1 - 9.5e-11 41.5 2.8 1e-09 38.2 0.3 2.8 2 1 0 2 2 2 1 Rare lipoprotein A (RlpA)-like double-psi beta-barrel Barwin PF00967.12 CCF31782.1 - 5.1e-05 22.9 1.2 0.00015 21.4 0.1 2.0 2 0 0 2 2 2 1 Barwin family Pollen_allerg_1 PF01357.16 CCF31782.1 - 0.0072 16.1 2.3 0.012 15.3 1.6 1.3 1 0 0 1 1 1 1 Pollen allergen BNR PF02012.15 CCF31782.1 - 0.0079 15.8 0.1 0.029 14.1 0.1 2.1 1 0 0 1 1 1 1 BNR/Asp-box repeat Mo-co_dimer PF03404.11 CCF31782.1 - 0.017 14.7 0.1 0.038 13.6 0.1 1.6 1 1 0 1 1 1 0 Mo-co oxidoreductase dimerisation domain DUF4340 PF14238.1 CCF31782.1 - 0.024 14.3 0.1 0.037 13.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4340) Disintegrin PF00200.18 CCF31786.1 - 1e-18 67.3 32.0 1e-18 67.3 22.2 4.8 3 2 1 4 4 4 1 Disintegrin Reprolysin_2 PF13574.1 CCF31786.1 - 3e-15 56.7 2.6 3e-15 56.7 1.8 2.2 2 1 1 3 3 3 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 CCF31786.1 - 1.3e-12 48.0 5.5 1.3e-12 48.0 3.8 3.3 2 1 1 3 3 3 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.1 CCF31786.1 - 1.3e-10 41.1 1.5 1.3e-10 41.1 1.1 1.8 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Sensor PF13796.1 CCF31786.1 - 0.034 13.7 0.0 0.044 13.3 0.0 1.1 1 0 0 1 1 1 0 Putative sensor Synaptobrevin PF00957.16 CCF31786.1 - 1.5 8.5 3.6 2.5 7.7 2.5 1.3 1 0 0 1 1 1 0 Synaptobrevin GP41 PF00517.12 CCF31786.1 - 2.6 7.5 4.2 0.56 9.7 0.0 1.8 2 0 0 2 2 2 0 Retroviral envelope protein FLILHELTA PF10306.4 CCF31787.1 - 3.5e-26 91.0 0.0 5.3e-26 90.4 0.0 1.3 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA Pkinase PF00069.20 CCF31788.1 - 1.4e-15 57.1 0.0 3e-15 56.0 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF31788.1 - 1.4e-12 47.2 0.0 1.5e-11 43.8 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.9 CCF31788.1 - 3.5e-07 29.4 0.1 9.7e-07 28.0 0.1 1.6 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CCF31788.1 - 0.00058 19.6 0.1 0.00094 18.9 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 CCF31788.1 - 0.027 13.4 0.0 0.036 13.0 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.15 CCF31788.1 - 0.048 13.2 0.0 0.071 12.6 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.17 CCF31788.1 - 0.051 12.9 0.0 0.087 12.1 0.0 1.4 1 0 0 1 1 1 0 RIO1 family UPF0180 PF03698.8 CCF31789.1 - 0.0069 16.2 1.9 0.33 10.8 0.1 2.2 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0180) Msg2_C PF12373.3 CCF31789.1 - 0.64 9.2 4.1 20 4.5 0.1 3.3 1 1 2 3 3 3 0 Major surface glycoprotein 2 C terminal NOA36 PF06524.7 CCF31789.1 - 2.1 7.5 5.6 2.3 7.3 3.9 1.1 1 0 0 1 1 1 0 NOA36 protein Pyr_redox_3 PF13738.1 CCF31790.1 - 4.8e-25 88.8 0.0 7.3e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 CCF31790.1 - 8.2e-12 44.0 0.1 2.6e-11 42.4 0.0 1.8 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 CCF31790.1 - 1.8e-08 34.2 0.0 1.3e-07 31.5 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF31790.1 - 8.5e-06 25.7 0.0 0.045 13.6 0.0 2.7 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF31790.1 - 3.6e-05 22.9 0.0 0.0043 16.1 0.0 2.3 2 0 0 2 2 2 1 Thi4 family DAO PF01266.19 CCF31790.1 - 0.00022 20.2 1.6 0.0079 15.1 0.1 2.8 3 1 0 3 3 3 1 FAD dependent oxidoreductase Shikimate_DH PF01488.15 CCF31790.1 - 0.0029 17.7 0.0 0.32 11.0 0.0 3.4 4 0 0 4 4 4 1 Shikimate / quinate 5-dehydrogenase Lycopene_cycl PF05834.7 CCF31790.1 - 0.0041 16.0 0.1 0.043 12.7 0.0 2.5 2 1 0 2 2 2 1 Lycopene cyclase protein FAD_oxidored PF12831.2 CCF31790.1 - 0.024 13.7 0.0 0.057 12.4 0.0 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase Amino_oxidase PF01593.19 CCF31790.1 - 0.053 12.5 0.2 0.48 9.4 0.0 2.3 2 1 0 3 3 3 0 Flavin containing amine oxidoreductase K_oxygenase PF13434.1 CCF31790.1 - 0.065 12.1 0.0 0.6 8.9 0.0 2.3 3 0 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.17 CCF31790.1 - 0.068 12.0 0.9 4.1 6.1 0.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A FmdA_AmdA PF03069.10 CCF31791.1 - 2.2e-111 372.1 0.0 2.5e-111 371.9 0.0 1.0 1 0 0 1 1 1 1 Acetamidase/Formamidase family OTU PF02338.14 CCF31792.1 - 6.9e-13 49.2 0.0 1.1e-12 48.6 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Bromodomain PF00439.20 CCF31793.1 - 3.5e-42 142.1 1.7 4.9e-22 77.6 0.1 2.7 2 0 0 2 2 2 2 Bromodomain BAH PF01426.13 CCF31793.1 - 2.4e-16 59.5 0.3 6e-16 58.2 0.2 1.7 1 0 0 1 1 1 1 BAH domain Ribosomal_60s PF00428.14 CCF31793.1 - 0.00053 20.3 8.3 0.00053 20.3 5.8 3.9 4 1 0 4 4 4 1 60s Acidic ribosomal protein RR_TM4-6 PF06459.7 CCF31793.1 - 0.00083 19.3 11.5 0.00083 19.3 8.0 4.2 5 0 0 5 5 5 1 Ryanodine Receptor TM 4-6 MORN PF02493.15 CCF31794.1 - 0.023 14.3 0.4 0.055 13.2 0.3 1.7 1 0 0 1 1 1 0 MORN repeat PAS_9 PF13426.1 CCF31796.1 - 2.5e-32 111.3 0.0 6e-18 65.1 0.0 3.7 3 0 0 3 3 3 3 PAS domain PAS_3 PF08447.6 CCF31796.1 - 1.4e-18 66.8 0.0 3.8e-11 42.9 0.0 4.1 4 0 0 4 4 4 3 PAS fold PAS PF00989.19 CCF31796.1 - 5.6e-16 58.3 0.0 7.8e-07 28.8 0.0 4.0 3 1 0 3 3 3 3 PAS fold GATA PF00320.22 CCF31796.1 - 2.9e-15 55.3 7.4 6.3e-15 54.2 5.1 1.6 1 0 0 1 1 1 1 GATA zinc finger PAS_4 PF08448.5 CCF31796.1 - 1.1e-09 38.3 0.0 0.0029 17.6 0.0 3.5 3 0 0 3 3 3 2 PAS fold PAS_11 PF14598.1 CCF31796.1 - 1.3e-08 34.7 0.0 0.0063 16.4 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS_2 PF08446.6 CCF31796.1 - 9.7e-05 22.7 0.0 0.12 12.8 0.0 3.4 3 0 0 3 3 3 1 PAS fold CAS_CSE1 PF03378.10 CCF31798.1 - 1.8e-27 95.7 0.0 1.9e-27 95.6 0.0 1.0 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus DUF3094 PF11293.3 CCF31798.1 - 0.36 10.3 0.3 0.36 10.3 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) DIT1_PvcA PF05141.7 CCF31799.1 - 1.1e-46 159.4 0.0 1.2e-46 159.2 0.0 1.0 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein Tup_N PF08581.5 CCF31800.1 - 7.3e-19 67.7 7.7 9.4e-19 67.3 5.4 1.1 1 0 0 1 1 1 1 Tup N-terminal LXG PF04740.7 CCF31800.1 - 0.0011 18.7 0.6 0.0014 18.5 0.4 1.0 1 0 0 1 1 1 1 LXG domain of WXG superfamily DUF2465 PF10239.4 CCF31800.1 - 0.025 13.7 0.7 0.027 13.6 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2465) USP8_interact PF08941.5 CCF31800.1 - 0.092 12.0 2.3 0.11 11.8 1.6 1.1 1 0 0 1 1 1 0 USP8 interacting DUF724 PF05266.9 CCF31800.1 - 0.097 12.2 2.7 0.11 12.0 1.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TPX2 PF06886.6 CCF31800.1 - 1.1 9.4 4.1 10 6.2 2.9 2.2 1 1 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) COMP PF11598.3 CCF31800.1 - 4.6 7.3 6.8 14 5.8 4.7 1.8 1 1 0 1 1 1 0 Cartilage oligomeric matrix protein DUF1180 PF06679.7 CCF31801.1 - 2.8 7.7 4.3 1.1 9.1 1.4 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1180) Cas1_AcylT PF07779.7 CCF31802.1 - 9.1e-65 218.9 18.2 1.3e-63 215.2 12.6 2.4 1 1 0 1 1 1 1 10 TM Acyl Transferase domain found in Cas1p PC-Esterase PF13839.1 CCF31802.1 - 5.2e-19 69.0 0.0 7.4e-19 68.5 0.0 1.2 1 0 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Nuc_deoxyrib_tr PF05014.10 CCF31804.1 - 0.0017 18.1 0.0 0.0021 17.9 0.0 1.2 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase DUF2360 PF10152.4 CCF31805.1 - 9.2 6.5 7.2 12 6.1 5.0 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) SF3b1 PF08920.5 CCF31807.1 - 5.7e-39 133.4 10.4 2.8e-38 131.2 0.5 2.5 1 1 1 2 2 2 2 Splicing factor 3B subunit 1 HEAT PF02985.17 CCF31807.1 - 0.0028 17.5 1.9 0.54 10.4 0.0 4.1 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.1 CCF31807.1 - 0.0082 16.4 0.0 0.56 10.5 0.0 3.3 3 1 1 4 4 4 2 HEAT repeats HEAT_EZ PF13513.1 CCF31807.1 - 0.28 11.7 3.5 1.2e+02 3.3 0.0 4.8 3 2 2 5 5 5 0 HEAT-like repeat OGG_N PF07934.7 CCF31808.1 - 5.6e-16 58.5 0.1 1.6e-15 57.1 0.0 1.7 1 1 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.20 CCF31808.1 - 1.5e-11 44.4 0.0 3.2e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 CCF31808.1 - 0.0068 16.0 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif LSM PF01423.17 CCF31809.1 - 2.7e-15 55.6 0.9 3.7e-15 55.2 0.6 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 CCF31809.1 - 0.0013 18.6 0.0 0.0017 18.2 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain Gemin7 PF11095.3 CCF31809.1 - 0.051 13.3 0.0 0.082 12.6 0.0 1.4 1 1 0 1 1 1 0 Gem-associated protein 7 (Gemin7) DRMBL PF07522.9 CCF31810.1 - 2.3e-33 114.5 0.1 4.6e-33 113.5 0.0 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.2 CCF31810.1 - 4.1e-11 42.7 0.0 7.9e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Isochorismatase PF00857.15 CCF31811.1 - 5.8e-28 97.9 0.0 6.6e-28 97.8 0.0 1.0 1 0 0 1 1 1 1 Isochorismatase family TB PF00683.12 CCF31813.1 - 0.37 10.4 3.4 0.67 9.5 2.3 1.4 1 0 0 1 1 1 0 TB domain DUF3505 PF12013.3 CCF31814.1 - 0.021 15.0 0.3 0.023 14.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3505) HSBP1 PF06825.7 CCF31816.1 - 1.5e-15 56.5 0.1 1.7e-15 56.3 0.1 1.1 1 0 0 1 1 1 1 Heat shock factor binding protein 1 Baculo_PEP_C PF04513.7 CCF31816.1 - 0.0098 15.7 0.2 0.011 15.5 0.1 1.1 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus SF-assemblin PF06705.6 CCF31816.1 - 0.026 13.6 0.1 0.03 13.4 0.1 1.0 1 0 0 1 1 1 0 SF-assemblin/beta giardin CheX PF13690.1 CCF31816.1 - 0.045 13.6 0.1 0.05 13.4 0.0 1.2 1 0 0 1 1 1 0 Chemotaxis phosphatase CheX DUF1664 PF07889.7 CCF31816.1 - 0.057 13.2 0.0 0.068 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF2884 PF11101.3 CCF31816.1 - 0.067 12.5 0.1 0.073 12.4 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) Matrilin_ccoil PF10393.4 CCF31816.1 - 0.076 12.3 0.1 0.99 8.8 0.1 2.1 1 1 1 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin TipAS PF07739.8 CCF31816.1 - 0.079 13.2 0.0 0.12 12.7 0.0 1.4 1 1 0 1 1 1 0 TipAS antibiotic-recognition domain DUF2240 PF09999.4 CCF31816.1 - 0.079 12.3 0.0 0.079 12.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2240) Thiol_cytolysin PF01289.14 CCF31816.1 - 0.11 10.8 0.0 0.12 10.7 0.0 1.0 1 0 0 1 1 1 0 Thiol-activated cytolysin Erythro-docking PF09277.6 CCF31816.1 - 0.39 10.4 2.2 2.4 7.9 0.2 2.4 1 1 2 3 3 3 0 Erythronolide synthase, docking Thioredoxin PF00085.15 CCF31817.1 - 6.7e-61 202.4 0.0 4.7e-31 106.5 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.7 CCF31817.1 - 1.2e-25 89.9 0.8 4.2e-25 88.2 0.5 1.9 2 0 0 2 2 2 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.1 CCF31817.1 - 2.6e-17 63.0 0.0 6e-08 32.8 0.0 3.4 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.1 CCF31817.1 - 3.1e-12 46.3 0.0 1.5e-05 24.9 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.1 CCF31817.1 - 2.6e-11 43.4 0.0 2.1e-05 24.5 0.0 3.4 3 1 1 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.16 CCF31817.1 - 3.7e-07 29.8 0.0 0.0041 16.7 0.0 2.4 2 0 0 2 2 2 2 AhpC/TSA family Redoxin PF08534.5 CCF31817.1 - 7.1e-06 25.6 0.1 0.0063 16.0 0.0 2.3 2 0 0 2 2 2 2 Redoxin Thioredoxin_9 PF14595.1 CCF31817.1 - 9.2e-05 22.0 0.0 0.26 10.8 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_4 PF13462.1 CCF31817.1 - 0.00051 20.0 0.6 0.54 10.2 0.0 3.9 3 2 2 5 5 5 1 Thioredoxin Thioredoxin_3 PF13192.1 CCF31817.1 - 0.0013 18.5 0.0 0.38 10.5 0.0 2.6 2 0 0 2 2 2 1 Thioredoxin domain HyaE PF07449.6 CCF31817.1 - 0.017 14.9 0.0 0.12 12.2 0.0 2.2 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Glutaredoxin PF00462.19 CCF31817.1 - 0.076 13.0 0.0 22 5.1 0.0 2.8 2 0 0 2 2 2 0 Glutaredoxin DDE_Tnp_1_2 PF13586.1 CCF31817.1 - 0.14 12.3 0.0 0.42 10.8 0.0 1.8 2 0 0 2 2 1 0 Transposase DDE domain Ribosomal_S14 PF00253.16 CCF31818.1 - 3.5e-18 64.7 4.5 3.8e-18 64.6 3.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DUF4428 PF14471.1 CCF31818.1 - 0.11 12.2 1.1 0.13 12.0 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) ZZ PF00569.12 CCF31818.1 - 0.19 11.2 4.1 1.9 8.0 2.8 2.1 1 1 0 1 1 1 0 Zinc finger, ZZ type Prim_Zn_Ribbon PF08273.7 CCF31818.1 - 0.3 11.1 1.6 2 8.5 0.1 2.1 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase GTP_EFTU PF00009.22 CCF31820.1 - 8.6e-60 201.3 0.3 1.2e-59 200.9 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 CCF31820.1 - 3.5e-26 91.2 0.0 9.4e-26 89.8 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 CCF31820.1 - 2.9e-16 59.3 4.8 3e-16 59.2 2.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 CCF31820.1 - 6.4e-06 26.1 0.0 1.2e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.1 CCF31820.1 - 0.00047 19.7 0.9 0.0015 18.1 0.6 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Miro PF08477.8 CCF31820.1 - 0.00093 19.6 0.0 0.0017 18.8 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein PduV-EutP PF10662.4 CCF31820.1 - 0.09 12.2 0.2 9.3 5.7 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.7 CCF31820.1 - 0.09 11.9 0.1 0.3 10.1 0.1 1.7 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region cobW PF02492.14 CCF31820.1 - 0.11 11.9 0.5 0.87 9.0 0.0 2.4 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain DUF2011 PF09428.5 CCF31821.1 - 2.9e-22 78.9 22.5 7.4e-22 77.6 15.6 1.6 1 1 0 1 1 1 1 Fungal protein of unknown function (DUF2011) FMO-like PF00743.14 CCF31822.1 - 5.8e-05 21.4 0.0 6.6e-05 21.3 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like GMC_oxred_N PF00732.14 CCF31824.1 - 7.8e-33 113.8 0.0 1.6e-32 112.8 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF31824.1 - 5e-21 75.5 0.9 2e-20 73.5 0.6 1.9 2 0 0 2 2 2 1 GMC oxidoreductase DAO PF01266.19 CCF31824.1 - 1.4e-08 34.0 1.2 2.5e-05 23.3 0.2 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CCF31824.1 - 3e-05 23.0 7.1 0.0004 19.3 4.9 2.4 1 1 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 CCF31824.1 - 0.00021 19.8 0.9 0.00021 19.8 0.7 1.7 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.1 CCF31824.1 - 0.00022 21.1 0.2 0.00022 21.1 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF31824.1 - 0.0004 20.3 0.4 0.01 15.6 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 CCF31824.1 - 0.0019 17.3 2.2 0.0097 15.0 0.8 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.12 CCF31824.1 - 0.0042 16.2 0.2 0.018 14.1 0.4 1.8 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.14 CCF31824.1 - 0.0074 15.3 0.3 0.016 14.2 0.2 1.6 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.7 CCF31824.1 - 0.011 14.6 0.2 0.018 13.9 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Serglycin PF04360.7 CCF31824.1 - 0.012 15.3 0.9 0.026 14.2 0.6 1.5 1 0 0 1 1 1 0 Serglycin Pyr_redox PF00070.22 CCF31824.1 - 0.029 14.7 1.2 0.17 12.2 0.3 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase PS-DH PF14765.1 CCF31825.1 - 9.9e-16 57.7 0.8 1.1e-14 54.2 0.1 2.4 2 0 0 2 2 2 1 Polyketide synthase dehydratase Methyltransf_12 PF08242.7 CCF31825.1 - 1e-15 58.0 0.0 3.8e-15 56.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Acyl_transf_1 PF00698.16 CCF31825.1 - 7.4e-09 35.3 0.0 5.3e-08 32.5 0.0 2.2 1 1 0 1 1 1 1 Acyl transferase domain Methyltransf_11 PF08241.7 CCF31825.1 - 1.5e-07 31.8 0.0 4.9e-07 30.1 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF31825.1 - 2.8e-07 30.3 0.0 6e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF31825.1 - 1.2e-05 25.8 0.1 5.2e-05 23.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_16 PF10294.4 CCF31825.1 - 0.002 17.6 0.0 0.008 15.6 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_31 PF13847.1 CCF31825.1 - 0.25 10.9 0.0 0.51 9.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Spc24 PF08286.6 CCF31826.1 - 0.00055 19.6 6.4 0.0089 15.7 0.1 2.2 1 1 1 2 2 2 2 Spc24 subunit of Ndc80 Mod_r PF07200.8 CCF31826.1 - 0.0033 17.3 6.0 0.0036 17.2 4.2 1.0 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Abi_C PF14355.1 CCF31826.1 - 0.025 14.4 1.4 0.13 12.2 0.9 2.0 1 1 0 1 1 1 0 Abortive infection C-terminus Scaffolding_pro PF11418.3 CCF31826.1 - 0.028 14.7 1.9 0.039 14.2 1.3 1.3 1 0 0 1 1 1 0 Phi29 scaffolding protein Streptin-Immun PF11083.3 CCF31826.1 - 0.049 13.6 0.6 0.12 12.3 0.2 1.7 1 1 1 2 2 2 0 Lantibiotic streptin immunity protein TEX12 PF15219.1 CCF31826.1 - 0.05 13.5 0.4 0.063 13.2 0.3 1.3 1 0 0 1 1 1 0 Testis-expressed 12 HisKA_2 PF07568.7 CCF31826.1 - 0.066 13.0 2.1 0.1 12.4 1.3 1.5 1 1 0 1 1 1 0 Histidine kinase Peptidase_M55 PF04951.8 CCF31826.1 - 0.069 12.3 2.2 0.077 12.1 1.5 1.1 1 0 0 1 1 1 0 D-aminopeptidase Viral_P18 PF04521.8 CCF31826.1 - 0.082 12.3 4.9 0.057 12.8 2.3 1.5 1 1 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein V_ATPase_I PF01496.14 CCF31826.1 - 0.085 10.7 2.5 0.089 10.6 1.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EAP30 PF04157.11 CCF31826.1 - 0.11 11.6 6.5 0.13 11.4 4.5 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family Retrotrans_gag PF03732.12 CCF31826.1 - 0.12 12.4 1.2 0.18 11.9 0.4 1.5 1 1 0 1 1 1 0 Retrotransposon gag protein Remorin_C PF03763.8 CCF31826.1 - 0.24 10.9 5.5 0.32 10.5 3.8 1.2 1 0 0 1 1 1 0 Remorin, C-terminal region HAUS-augmin3 PF14932.1 CCF31826.1 - 0.27 10.3 7.3 0.36 9.9 5.1 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 IncA PF04156.9 CCF31826.1 - 0.73 9.3 8.7 1.2 8.6 6.0 1.4 1 1 0 1 1 1 0 IncA protein DUF3571 PF12095.3 CCF31826.1 - 0.84 9.9 3.7 0.59 10.4 0.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3571) APG6 PF04111.7 CCF31826.1 - 1.1 8.2 6.1 1.3 8.0 4.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4164 PF13747.1 CCF31826.1 - 1.1 9.3 13.0 0.91 9.6 4.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) Apc5 PF12862.2 CCF31826.1 - 1.5 8.6 7.3 3.6 7.4 3.9 1.9 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 5 Histone_HNS PF00816.16 CCF31826.1 - 1.8 9.1 5.6 2.2 8.8 3.4 1.6 1 1 1 2 2 2 0 H-NS histone family DUF607 PF04678.8 CCF31826.1 - 2 8.3 4.9 2.9 7.8 3.4 1.5 1 1 0 1 1 1 0 Protein of unknown function, DUF607 MbeD_MobD PF04899.7 CCF31826.1 - 2.5 8.0 7.0 1.5 8.7 2.0 2.0 1 1 1 2 2 2 0 MbeD/MobD like Integrase_AP2 PF14657.1 CCF31826.1 - 5.8 6.7 5.8 32 4.4 1.1 2.4 2 0 0 2 2 2 0 AP2-like DNA-binding integrase domain DUF2027 PF09640.5 CCF31827.1 - 0.065 12.5 0.0 0.1 11.9 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF2027) eIF3g PF12353.3 CCF31829.1 - 2.4e-25 88.9 0.6 3e-25 88.6 0.4 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G MFS_1 PF07690.11 CCF31830.1 - 2.8e-10 39.4 1.6 4.9e-10 38.6 1.1 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF31830.1 - 0.00011 20.9 0.1 0.00014 20.6 0.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter CLN3 PF02487.12 CCF31830.1 - 0.051 12.3 0.5 0.14 10.9 0.2 1.7 2 0 0 2 2 2 0 CLN3 protein Lipase_GDSL_2 PF13472.1 CCF31832.1 - 7.7e-13 48.9 0.0 1.1e-12 48.4 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 CCF31832.1 - 0.025 14.4 0.3 0.05 13.4 0.2 1.5 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase RasGEF PF00617.14 CCF31834.1 - 1.2e-62 210.9 0.1 2.1e-62 210.2 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 CCF31834.1 - 5.3e-28 97.1 0.8 1.2e-27 96.0 0.6 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif DUF3425 PF11905.3 CCF31835.1 - 5.7e-24 84.5 0.9 8.6e-24 83.9 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) PBP_sp32 PF07222.7 CCF31836.1 - 2 7.5 7.5 2.1 7.4 5.2 1.0 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF4336 PF14234.1 CCF31837.1 - 8.8e-14 51.3 0.0 1.1e-08 34.6 0.0 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF4336) BTB PF00651.26 CCF31838.1 - 9.8e-12 44.8 0.0 1.9e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain CNH PF00780.17 CCF31839.1 - 1.3e-83 280.5 0.0 4.6e-83 278.8 0.0 1.8 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.1 CCF31839.1 - 5.4e-45 152.6 0.0 1.3e-44 151.4 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.15 CCF31839.1 - 1.3e-36 126.1 0.0 2.7e-36 125.1 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.16 CCF31839.1 - 1.9e-14 53.1 0.0 3.7e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GMC_oxred_N PF00732.14 CCF31840.1 - 8.3e-37 126.9 0.0 9.1e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.7 CCF31840.1 - 0.00051 19.0 0.0 0.00072 18.5 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.19 CCF31840.1 - 0.0008 18.4 0.0 0.00091 18.2 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 CCF31840.1 - 0.0035 16.4 0.0 0.0053 15.8 0.0 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.9 CCF31840.1 - 0.0066 16.3 0.0 0.0066 16.3 0.0 1.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF31840.1 - 0.034 14.1 0.1 0.089 12.8 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.13 CCF31840.1 - 0.034 14.1 0.0 0.051 13.5 0.0 1.2 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox PF00070.22 CCF31840.1 - 0.055 13.8 0.0 0.096 13.1 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF31840.1 - 0.057 12.2 0.0 0.083 11.7 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain PSD1 PF07587.6 CCF31840.1 - 0.066 12.6 0.0 0.095 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1553) ApbA PF02558.11 CCF31840.1 - 0.068 12.6 0.1 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.17 CCF31840.1 - 0.14 10.9 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A HI0933_like PF03486.9 CCF31840.1 - 0.15 10.5 0.0 0.21 10.0 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein FAD_oxidored PF12831.2 CCF31840.1 - 0.17 10.9 0.1 0.27 10.2 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase DUF3060 PF11259.3 CCF31841.1 - 0.15 11.7 0.6 0.55 9.8 0.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3060) HMG_CoA_synt_C PF08540.5 CCF31844.1 - 5.1e-51 173.8 0.0 5.7e-51 173.6 0.0 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal NADH-u_ox-rdase PF10785.4 CCF31845.1 - 1.1e-33 115.3 0.3 2.1e-33 114.4 0.1 1.5 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.2 CCF31845.1 - 3.1e-32 110.1 0.1 4.5e-32 109.6 0.0 1.2 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit AAA PF00004.24 CCF31846.1 - 1.5e-15 57.5 0.0 2.8e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CCF31846.1 - 3e-05 24.1 0.3 0.0029 17.7 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_16 PF13191.1 CCF31846.1 - 0.00033 20.6 0.3 0.0011 18.9 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 CCF31846.1 - 0.0039 16.9 0.1 0.011 15.5 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 CCF31846.1 - 0.027 14.2 0.1 0.072 12.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 CCF31846.1 - 0.089 12.6 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Tannase PF07519.6 CCF31848.1 - 3.5e-53 180.9 0.4 4.7e-53 180.5 0.3 1.2 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_6 PF12697.2 CCF31848.1 - 0.00028 20.8 0.2 0.00064 19.6 0.1 1.6 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF31848.1 - 0.0044 16.6 0.0 0.0067 16.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF31848.1 - 0.028 14.1 0.3 0.042 13.6 0.2 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family MFS_1 PF07690.11 CCF31849.1 - 7.9e-19 67.5 8.2 9e-19 67.3 5.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF31849.1 - 6.9e-13 47.9 7.2 9e-13 47.5 4.8 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 CCF31849.1 - 6.1e-06 24.7 4.2 6.2e-06 24.6 2.9 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.1 CCF31849.1 - 1.2e-05 23.9 2.7 1.6e-05 23.4 1.8 1.4 1 1 0 1 1 1 1 MFS/sugar transport protein DUF202 PF02656.10 CCF31849.1 - 1.7 8.9 5.5 4.4 7.5 1.2 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF202) DUF3366 PF11846.3 CCF31850.1 - 0.027 14.3 0.1 0.035 13.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3366) Rubi_NSP_C PF12601.3 CCF31850.1 - 0.032 14.1 0.9 0.076 12.9 0.1 2.1 2 0 0 2 2 2 0 Rubivirus non-structural protein YqjK PF13997.1 CCF31850.1 - 0.49 10.5 3.3 0.79 9.9 0.7 2.1 1 1 1 2 2 2 0 YqjK-like protein TPR_11 PF13414.1 CCF31851.1 - 5.1e-15 54.8 5.5 1.1e-11 44.2 1.2 2.3 1 1 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 CCF31851.1 - 3.4e-13 48.5 2.2 0.0053 16.3 0.1 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 CCF31851.1 - 1.4e-12 46.4 4.2 0.0044 16.8 0.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.1 CCF31851.1 - 3e-08 33.2 0.9 0.00077 19.4 0.2 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 CCF31851.1 - 5.4e-07 30.1 8.2 9.1e-06 26.2 1.8 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 CCF31851.1 - 4.6e-06 26.7 5.2 0.078 13.6 0.1 3.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 CCF31851.1 - 1.6e-05 24.3 1.4 0.18 11.6 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 CCF31851.1 - 1.7e-05 25.0 3.2 0.00033 20.9 0.5 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 CCF31851.1 - 3.9e-05 23.1 0.1 0.74 9.7 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 CCF31851.1 - 8.3e-05 22.4 3.2 0.0014 18.5 0.6 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 CCF31851.1 - 0.0043 16.8 1.1 0.064 13.1 0.1 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat BTAD PF03704.12 CCF31851.1 - 0.0066 16.7 0.7 0.015 15.5 0.5 1.6 1 1 0 1 1 1 1 Bacterial transcriptional activator domain XPC-binding PF09280.6 CCF31851.1 - 0.017 14.5 2.6 0.017 14.5 1.8 2.1 2 0 0 2 2 2 0 XPC-binding domain Apc3 PF12895.2 CCF31851.1 - 0.18 11.9 1.1 0.84 9.8 0.7 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 CCF31851.1 - 0.26 11.8 4.1 2.9 8.5 0.3 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat ABC_tran PF00005.22 CCF31852.1 - 1.9e-32 112.4 0.0 3.5e-32 111.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 CCF31852.1 - 6.4e-19 68.4 3.3 6.4e-19 68.4 2.3 2.3 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.14 CCF31852.1 - 4.6e-05 22.7 0.0 0.00016 20.9 0.0 1.7 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF31852.1 - 0.00028 20.9 0.0 0.02 14.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain PAM2 PF07145.10 CCF31852.1 - 0.00031 20.0 0.4 0.012 15.1 0.1 2.6 2 0 0 2 2 2 1 Ataxin-2 C-terminal region DUF258 PF03193.11 CCF31852.1 - 0.004 16.3 0.0 0.0086 15.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_17 PF13207.1 CCF31852.1 - 0.017 15.9 0.0 0.043 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 CCF31852.1 - 0.017 14.5 0.4 0.048 13.1 0.2 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.1 CCF31852.1 - 0.018 14.6 0.1 0.061 12.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 CCF31852.1 - 0.021 13.7 0.1 0.5 9.2 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein Zeta_toxin PF06414.7 CCF31852.1 - 0.04 13.0 0.0 0.11 11.5 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin SbcCD_C PF13558.1 CCF31852.1 - 0.63 9.9 2.7 0.63 9.9 0.1 2.4 2 1 0 2 2 1 0 Putative exonuclease SbcCD, C subunit Acyl-CoA_ox_N PF14749.1 CCF31855.1 - 5.8e-16 58.9 0.1 7.5e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal DUF3425 PF11905.3 CCF31856.1 - 0.0048 16.7 0.9 0.016 15.0 0.6 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) HTH_Tnp_Tc5 PF03221.11 CCF31857.1 - 9.7e-11 41.3 0.0 1.5e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF31857.1 - 0.021 14.3 0.0 0.045 13.3 0.0 1.6 2 0 0 2 2 2 0 helix-turn-helix, Psq domain Glyco_hydro_61 PF03443.9 CCF31858.1 - 3.5e-36 125.0 0.0 4.2e-36 124.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Peptidase_C53 PF05550.6 CCF31858.1 - 0.1 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Pestivirus Npro endopeptidase C53 Glyco_hydro_61 PF03443.9 CCF31859.1 - 1.5e-37 129.5 0.0 8.4e-37 127.0 0.0 1.8 1 1 1 2 2 2 1 Glycosyl hydrolase family 61 SOCS PF12610.3 CCF31859.1 - 0.23 11.7 2.3 0.43 10.9 1.6 1.4 1 0 0 1 1 1 0 Suppressor of cytokine signalling bZIP_1 PF00170.16 CCF31860.1 - 1.6e-08 34.4 10.9 2.3e-08 33.8 7.6 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 CCF31860.1 - 0.0025 17.5 9.9 0.0025 17.5 6.9 1.5 2 0 0 2 2 2 1 Basic region leucine zipper PBP_sp32 PF07222.7 CCF31860.1 - 0.0085 15.2 2.6 0.011 14.9 1.8 1.2 1 0 0 1 1 1 1 Proacrosin binding protein sp32 PRP1_N PF06424.7 CCF31860.1 - 0.028 14.7 4.1 0.039 14.2 2.9 1.2 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal HrpA_pilin PF09589.5 CCF31860.1 - 0.09 13.2 4.2 0.14 12.5 2.9 1.3 1 0 0 1 1 1 0 HrpA pilus formation protein Matrilin_ccoil PF10393.4 CCF31860.1 - 0.092 12.1 0.9 0.15 11.4 0.7 1.3 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin CAF-1_p150 PF11600.3 CCF31860.1 - 0.14 11.5 11.5 0.19 11.1 7.9 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Ndc1_Nup PF09531.5 CCF31860.1 - 0.14 10.5 4.1 0.17 10.2 2.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup IncA PF04156.9 CCF31860.1 - 0.15 11.6 0.7 0.21 11.1 0.5 1.2 1 0 0 1 1 1 0 IncA protein Peptidase_S64 PF08192.6 CCF31860.1 - 0.48 8.7 4.4 0.58 8.4 3.0 1.0 1 0 0 1 1 1 0 Peptidase family S64 CDC45 PF02724.9 CCF31860.1 - 0.55 8.1 8.5 0.74 7.7 5.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF3359 PF11839.3 CCF31860.1 - 1.8 8.9 8.0 0.38 11.1 3.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3359) Presenilin PF01080.12 CCF31860.1 - 3.4 6.3 7.0 4.3 6.0 4.9 1.1 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.4 CCF31860.1 - 4.8 5.9 10.1 5.7 5.6 7.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Fork_head_N PF08430.7 CCF31860.1 - 8.4 6.7 19.6 5 7.5 1.5 2.1 2 0 0 2 2 2 0 Forkhead N-terminal region 2-Hacid_dh PF00389.25 CCF31862.1 - 2.5e-11 43.1 0.0 2.7e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain SMC_N PF02463.14 CCF31863.1 - 0.12 11.5 0.1 0.14 11.3 0.1 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Actin PF00022.14 CCF31864.1 - 1.2e-05 23.9 0.0 2.3e-05 23.0 0.0 1.7 1 1 0 1 1 1 1 Actin MFS_1 PF07690.11 CCF31867.1 - 3.7e-26 91.6 77.4 3.2e-25 88.5 34.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Flavodoxin_1 PF00258.20 CCF31868.1 - 1.3e-10 41.4 0.0 1.8e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin FMN_red PF03358.10 CCF31868.1 - 2.1e-08 33.8 0.0 2.8e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 CCF31868.1 - 3.9e-06 26.5 0.0 4.8e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.2 CCF31868.1 - 0.0031 17.5 0.0 0.12 12.4 0.0 2.1 1 1 1 2 2 2 1 Flavodoxin domain Flavodoxin_4 PF12682.2 CCF31868.1 - 0.044 13.1 0.2 0.37 10.1 0.1 2.0 1 1 0 1 1 1 0 Flavodoxin Methyltransf_22 PF13383.1 CCF31869.1 - 5.4e-25 88.3 0.0 7.2e-25 87.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_21 PF05050.7 CCF31869.1 - 2.6e-06 27.4 0.0 3.8e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain CoA_binding_3 PF13727.1 CCF31870.1 - 4.9 6.9 10.7 0.22 11.3 1.6 2.4 1 1 1 2 2 2 0 CoA-binding domain CTP_transf_2 PF01467.21 CCF31871.1 - 0.00038 20.5 0.9 0.004 17.2 0.6 2.5 1 1 0 1 1 1 1 Cytidylyltransferase FAD_syn PF06574.7 CCF31871.1 - 0.12 11.9 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 FAD synthetase MFS_1 PF07690.11 CCF31872.1 - 6.5e-24 84.2 41.0 2.7e-19 69.0 17.0 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily AMP-binding PF00501.23 CCF31878.1 - 7.7e-23 80.5 0.0 9.3e-23 80.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme D-aminoacyl_C PF07908.7 CCF31878.1 - 0.068 12.4 0.1 0.16 11.3 0.1 1.5 1 0 0 1 1 1 0 D-aminoacylase, C-terminal region DUF3328 PF11807.3 CCF31879.1 - 5.3e-25 88.3 1.7 6.3e-25 88.1 1.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) ADH_N PF08240.7 CCF31880.1 - 2.6e-10 40.0 0.0 5.5e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF31880.1 - 8.3e-09 35.0 0.0 1.7e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FSH1 PF03959.8 CCF31881.1 - 3.9e-32 111.4 0.0 4.9e-32 111.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.2 CCF31881.1 - 8.5e-06 25.8 1.8 0.012 15.4 0.6 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF31881.1 - 4.4e-05 23.2 0.2 7.2e-05 22.5 0.1 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 CCF31881.1 - 0.00013 21.4 0.1 0.0047 16.3 0.0 2.5 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase PhyH PF05721.8 CCF31882.1 - 5.4e-19 69.0 0.0 8.4e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) GGDN PF05165.7 CCF31882.1 - 0.13 11.2 0.1 0.21 10.6 0.1 1.2 1 0 0 1 1 1 0 GGDN family Atg8 PF02991.11 CCF31883.1 - 9.3e-39 131.5 0.1 1e-38 131.4 0.0 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.8 CCF31883.1 - 1.3e-06 28.5 0.0 1.5e-06 28.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Cu-oxidase_2 PF07731.9 CCF31885.1 - 2.2e-13 49.9 0.2 3e-13 49.4 0.2 1.2 1 0 0 1 1 1 1 Multicopper oxidase C1q PF00386.16 CCF31885.1 - 0.17 11.8 0.0 0.25 11.3 0.0 1.2 1 0 0 1 1 1 0 C1q domain TPR_12 PF13424.1 CCF31886.1 - 0.0028 17.5 0.0 0.4 10.6 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TauD PF02668.11 CCF31892.1 - 8.9e-52 176.3 0.3 1.1e-51 176.0 0.2 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Sld5 PF05916.6 CCF31893.1 - 5.4e-13 49.1 0.0 7.5e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 GINS complex protein Sod_Fe_C PF02777.13 CCF31894.1 - 8.5e-42 141.3 0.2 1.6e-41 140.3 0.1 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 CCF31894.1 - 8.6e-31 106.0 1.0 1.5e-30 105.2 0.7 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Zip PF02535.17 CCF31895.1 - 2.7 6.8 7.6 2.5 7.0 5.2 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter COesterase PF00135.23 CCF31898.1 - 3.2e-89 300.0 0.0 4.4e-89 299.5 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF31898.1 - 0.00015 21.4 0.4 0.00061 19.4 0.1 2.1 2 1 0 2 2 2 1 alpha/beta hydrolase fold La PF05383.12 CCF31899.1 - 1e-14 54.0 0.0 1.7e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 La domain RRM_1 PF00076.17 CCF31899.1 - 1.1e-09 37.8 0.2 2e-09 36.9 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF31899.1 - 2.9e-09 36.7 0.0 5.1e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF31899.1 - 4.4e-05 23.2 0.0 0.0001 22.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) S4 PF01479.20 CCF31900.1 - 1.6e-13 49.8 0.0 3.4e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.1 CCF31900.1 - 0.0036 16.8 0.0 0.0072 15.8 0.0 1.4 1 0 0 1 1 1 1 S4 domain Septin PF00735.13 CCF31901.1 - 8.4e-121 402.3 0.2 8.4e-121 402.3 0.1 1.8 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 CCF31901.1 - 6.5e-07 29.3 0.0 1.7e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CCF31901.1 - 6.3e-05 22.4 0.4 0.0038 16.6 0.0 2.9 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 CCF31901.1 - 8.7e-05 21.7 0.3 0.00061 19.0 0.2 2.2 1 1 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 CCF31901.1 - 0.00016 21.9 1.5 0.03 14.6 0.0 2.6 2 0 0 2 2 2 1 ABC transporter AAA_10 PF12846.2 CCF31901.1 - 0.00085 18.8 1.2 0.0023 17.3 0.8 1.9 1 1 0 1 1 1 1 AAA-like domain AIG1 PF04548.11 CCF31901.1 - 0.003 16.7 1.7 0.0059 15.7 0.0 2.2 2 0 0 2 2 2 1 AIG1 family Miro PF08477.8 CCF31901.1 - 0.0032 17.9 0.0 0.013 15.9 0.0 2.1 1 0 0 1 1 1 1 Miro-like protein AAA_22 PF13401.1 CCF31901.1 - 0.0051 16.9 0.1 0.037 14.1 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CCF31901.1 - 0.0052 16.8 0.1 0.017 15.0 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.18 CCF31901.1 - 0.0059 16.4 4.1 0.7 9.6 0.0 3.5 3 0 0 3 3 3 1 Dynamin family Ras PF00071.17 CCF31901.1 - 0.0071 15.7 0.1 0.043 13.2 0.0 2.2 2 0 0 2 2 2 1 Ras family AAA_29 PF13555.1 CCF31901.1 - 0.0092 15.4 0.0 0.018 14.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.13 CCF31901.1 - 0.03 13.8 0.0 0.03 13.8 0.0 2.2 3 0 0 3 3 2 0 FtsK/SpoIIIE family ATP_bind_1 PF03029.12 CCF31901.1 - 0.063 12.8 0.4 6.9 6.1 0.0 3.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein RNA_helicase PF00910.17 CCF31901.1 - 0.07 13.3 0.5 0.64 10.2 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_24 PF13479.1 CCF31901.1 - 0.079 12.5 0.4 0.22 11.0 0.0 2.0 2 0 0 2 2 1 0 AAA domain Exonuc_VII_L PF02601.10 CCF31901.1 - 0.14 11.3 7.7 0.27 10.3 5.3 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Strep_SA_rep PF06696.6 CCF31901.1 - 0.23 11.2 2.8 0.29 10.9 0.9 2.0 1 1 1 2 2 2 0 Streptococcal surface antigen repeat V_ATPase_I PF01496.14 CCF31901.1 - 0.23 9.2 5.7 3.9 5.2 6.0 1.4 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family MobB PF03205.9 CCF31901.1 - 0.29 10.8 0.1 0.29 10.8 0.0 2.6 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_32 PF13654.1 CCF31901.1 - 0.42 9.2 11.7 0.58 8.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain IncA PF04156.9 CCF31901.1 - 1.1 8.8 8.5 1.8 8.1 5.9 1.3 1 0 0 1 1 1 0 IncA protein Phage_GPO PF05929.6 CCF31901.1 - 1.5 7.9 7.9 0.99 8.6 4.0 1.7 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF87 PF01935.12 CCF31901.1 - 7.9 6.2 7.9 4 7.1 0.0 2.6 3 0 0 3 3 2 0 Domain of unknown function DUF87 adh_short PF00106.20 CCF31902.1 - 5.5e-15 55.6 4.7 1.1e-13 51.4 3.3 2.1 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF31902.1 - 4e-06 26.6 2.1 0.0019 17.9 0.3 2.2 2 0 0 2 2 2 2 KR domain adh_short_C2 PF13561.1 CCF31902.1 - 0.00019 21.3 0.5 0.0017 18.1 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 CCF31902.1 - 0.00048 20.1 1.8 0.00095 19.2 1.2 1.7 1 1 0 1 1 1 1 NADH(P)-binding Eno-Rase_NADH_b PF12242.3 CCF31902.1 - 0.0016 18.1 0.0 0.0037 17.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF2939 PF11159.3 CCF31902.1 - 0.0037 17.4 0.0 0.0082 16.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2939) Shikimate_DH PF01488.15 CCF31902.1 - 0.022 14.8 0.1 0.04 14.0 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.16 CCF31902.1 - 0.024 14.0 0.1 0.2 11.0 0.0 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.14 CCF31902.1 - 0.055 12.5 0.0 0.095 11.7 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain PALP PF00291.20 CCF31904.1 - 9.8e-28 97.2 0.0 2e-27 96.2 0.0 1.5 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Rhodanese PF00581.15 CCF31904.1 - 4.9e-11 42.9 0.0 2.8e-10 40.5 0.0 2.1 2 0 0 2 2 2 1 Rhodanese-like domain MFS_1 PF07690.11 CCF31905.1 - 3e-40 138.0 43.9 5.7e-40 137.1 29.3 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF31905.1 - 2.3e-18 65.7 22.8 3e-18 65.3 15.8 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 CCF31905.1 - 8e-18 64.2 6.6 8e-18 64.2 4.6 2.9 2 1 1 3 3 3 1 Sugar (and other) transporter Fungal_trans_2 PF11951.3 CCF31906.1 - 2.3e-08 33.0 0.3 8.7e-05 21.2 0.0 2.4 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF31906.1 - 0.0017 18.1 9.1 0.0041 16.9 6.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 5_nucleotid PF05761.9 CCF31906.1 - 0.26 9.7 0.0 0.38 9.2 0.0 1.2 1 0 0 1 1 1 0 5' nucleotidase family Septin PF00735.13 CCF31907.1 - 5.9e-104 347.0 0.1 5.9e-104 347.0 0.0 1.6 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 CCF31907.1 - 3e-05 23.9 0.0 6.5e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 CCF31907.1 - 3.1e-05 23.2 0.0 5.6e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 CCF31907.1 - 0.00015 21.6 0.9 0.56 9.9 0.0 2.8 2 1 1 3 3 3 2 Dynamin family AAA_17 PF13207.1 CCF31907.1 - 0.0079 17.0 2.8 0.041 14.7 0.1 2.7 1 1 1 2 2 2 1 AAA domain ABC_tran PF00005.22 CCF31907.1 - 0.017 15.3 0.0 0.22 11.8 0.0 2.5 2 1 0 2 2 2 0 ABC transporter Miro PF08477.8 CCF31907.1 - 0.023 15.1 0.1 0.077 13.4 0.0 2.0 2 0 0 2 2 2 0 Miro-like protein AAA_33 PF13671.1 CCF31907.1 - 0.042 13.7 0.1 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 CCF31907.1 - 0.078 13.1 0.2 0.31 11.1 0.0 2.2 2 2 0 2 2 2 0 AAA domain AAA_28 PF13521.1 CCF31907.1 - 0.84 9.5 5.4 1.7 8.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF1768 PF08719.6 CCF31908.1 - 1.3e-46 158.2 0.2 1.6e-46 157.9 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) DUF3574 PF12098.3 CCF31908.1 - 0.038 13.5 0.0 0.058 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3574) adh_short PF00106.20 CCF31909.1 - 4.9e-26 91.6 2.6 6.2e-26 91.2 1.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF31909.1 - 5.2e-15 55.8 0.0 6.9e-15 55.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF31909.1 - 4.7e-07 29.6 1.4 7.2e-07 29.0 1.0 1.3 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.13 CCF31909.1 - 0.00027 20.6 0.2 0.00044 19.9 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.16 CCF31909.1 - 0.0059 16.0 0.1 0.009 15.4 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.14 CCF31909.1 - 0.038 13.0 0.0 0.12 11.4 0.0 1.8 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Methyltransf_18 PF12847.2 CCF31909.1 - 0.05 14.1 0.0 0.19 12.3 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Polysacc_synt_2 PF02719.10 CCF31909.1 - 0.078 11.8 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein UDPG_MGDP_dh_N PF03721.9 CCF31909.1 - 0.081 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_12 PF08242.7 CCF31909.1 - 0.12 12.8 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Eno-Rase_NADH_b PF12242.3 CCF31909.1 - 1.5 8.6 4.6 0.77 9.5 0.6 2.3 3 0 0 3 3 3 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ICL PF00463.16 CCF31910.1 - 2.4e-202 672.7 0.0 2.8e-202 672.6 0.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.1 CCF31910.1 - 6e-13 48.5 0.1 3e-11 43.0 0.0 2.2 2 0 0 2 2 2 2 Phosphoenolpyruvate phosphomutase Arg_repressor_C PF02863.13 CCF31910.1 - 0.1 12.0 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 Arginine repressor, C-terminal domain Citrate_synt PF00285.16 CCF31911.1 - 2.7e-102 342.1 0.0 3.2e-102 341.9 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase Sulfotransfer_3 PF13469.1 CCF31912.1 - 0.11 13.4 5.4 0.27 12.1 3.8 1.7 1 1 0 1 1 1 0 Sulfotransferase family WSC PF01822.14 CCF31915.1 - 1.6e-06 27.9 8.3 3e-06 27.0 5.7 1.4 1 0 0 1 1 1 1 WSC domain Crisp PF08562.5 CCF31915.1 - 9.3 6.6 9.1 3.7 7.8 3.0 2.5 2 1 0 2 2 2 0 Crisp RIO1 PF01163.17 CCF31916.1 - 1.5e-69 233.1 0.2 3.1e-69 232.1 0.0 1.6 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 CCF31916.1 - 0.00022 21.0 0.1 0.13 11.9 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 CCF31916.1 - 0.0021 17.1 0.0 0.26 10.3 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Kelch_5 PF13854.1 CCF31917.1 - 3.2e-16 58.8 10.7 1.4e-09 37.6 0.2 5.7 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.1 CCF31917.1 - 6e-11 41.9 9.1 0.0027 17.4 0.2 5.0 4 1 0 4 4 4 4 Galactose oxidase, central domain Kelch_6 PF13964.1 CCF31917.1 - 2.2e-09 37.0 12.6 0.055 13.6 0.1 4.9 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.1 CCF31917.1 - 3.1e-05 23.9 9.5 0.12 12.5 0.1 5.0 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.20 CCF31917.1 - 5.2e-05 22.6 0.1 1.9 8.0 0.0 4.0 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.10 CCF31917.1 - 0.00026 20.6 10.7 0.21 11.3 0.1 4.9 6 0 0 6 6 6 2 Kelch motif SYF2 PF08231.7 CCF31919.1 - 8.5e-52 175.3 14.2 8.5e-52 175.3 9.8 1.8 2 0 0 2 2 2 1 SYF2 splicing factor ARD PF03079.9 CCF31919.1 - 6.7 6.6 8.8 0.36 10.7 0.5 2.6 1 1 1 2 2 2 0 ARD/ARD' family NAD_binding_10 PF13460.1 CCF31920.1 - 5.8e-12 45.9 0.0 9.6e-11 42.0 0.0 2.2 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF31920.1 - 1.5e-06 27.8 0.0 4.4e-06 26.2 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF31920.1 - 0.00032 19.5 0.0 0.0056 15.4 0.0 2.5 3 0 0 3 3 3 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 CCF31920.1 - 0.0061 16.4 0.0 0.047 13.6 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase YEATS PF03366.11 CCF31922.1 - 9.1e-29 99.0 0.1 1.4e-28 98.3 0.1 1.3 1 0 0 1 1 1 1 YEATS family L_lactis_ph-MCP PF06673.6 CCF31922.1 - 0.15 10.7 2.8 0.22 10.2 2.0 1.1 1 0 0 1 1 1 0 Lactococcus lactis bacteriophage major capsid protein MerR-DNA-bind PF09278.6 CCF31922.1 - 0.56 10.6 6.2 0.35 11.2 2.8 1.7 2 0 0 2 2 2 0 MerR, DNA binding DUF2404 PF10296.4 CCF31923.1 - 0.00011 22.2 0.0 0.00037 20.5 0.0 1.8 2 0 0 2 2 2 1 Putative integral membrane protein conserved region (DUF2404) Ins_P5_2-kin PF06090.7 CCF31924.1 - 1.7e-33 116.0 0.0 2e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Rubrerythrin PF02915.12 CCF31924.1 - 0.15 12.3 1.2 0.34 11.2 0.9 1.6 1 1 0 1 1 1 0 Rubrerythrin SET PF00856.23 CCF31925.1 - 9.2e-06 26.0 0.0 0.12 12.6 0.0 3.1 2 1 0 2 2 2 2 SET domain ABC_tran PF00005.22 CCF31927.1 - 1e-48 165.0 0.4 3.2e-27 95.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.2 CCF31927.1 - 2.2e-23 82.8 47.4 2.7e-15 56.2 15.2 2.9 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.1 CCF31927.1 - 2e-21 77.2 2.2 1.2e-05 25.4 0.0 4.7 4 1 1 5 5 4 4 AAA domain AAA_29 PF13555.1 CCF31927.1 - 1.2e-09 37.5 1.0 0.0003 20.2 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.14 CCF31927.1 - 7.2e-08 31.9 2.7 0.32 10.1 0.0 4.2 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 CCF31927.1 - 1.1e-07 32.4 0.4 0.017 15.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 CCF31927.1 - 2.7e-05 23.4 0.1 0.14 11.2 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 CCF31927.1 - 4.9e-05 23.3 0.6 0.51 10.2 0.0 2.9 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.1 CCF31927.1 - 0.00025 20.5 0.0 0.17 11.2 0.0 3.4 3 0 0 3 3 3 1 AAA domain Zeta_toxin PF06414.7 CCF31927.1 - 0.002 17.2 0.1 1 8.3 0.0 3.1 3 0 0 3 3 3 1 Zeta toxin AAA_22 PF13401.1 CCF31927.1 - 0.018 15.2 0.4 5.1 7.2 0.2 2.9 2 1 0 2 2 2 0 AAA domain AAA_15 PF13175.1 CCF31927.1 - 0.019 14.0 0.0 6.6 5.6 0.0 2.9 3 0 0 3 3 3 0 AAA ATPase domain RNA_helicase PF00910.17 CCF31927.1 - 0.037 14.2 0.0 1.9 8.7 0.0 2.5 2 0 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.12 CCF31927.1 - 0.043 13.2 0.0 54 3.1 0.0 3.8 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_30 PF13604.1 CCF31927.1 - 0.047 13.2 0.4 8.8 5.8 0.0 2.7 2 1 0 2 2 2 0 AAA domain SRP54 PF00448.17 CCF31927.1 - 0.051 13.0 1.0 8.8 5.7 0.3 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_10 PF12846.2 CCF31927.1 - 0.091 12.1 1.6 9.1 5.6 0.4 2.5 2 0 0 2 2 2 0 AAA-like domain G-alpha PF00503.15 CCF31927.1 - 0.1 11.2 0.0 1.4 7.5 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit DUF87 PF01935.12 CCF31927.1 - 0.11 12.2 1.4 3.3 7.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_33 PF13671.1 CCF31927.1 - 0.11 12.3 0.4 20 5.0 0.0 3.0 3 0 0 3 3 2 0 AAA domain AAA_19 PF13245.1 CCF31927.1 - 0.13 12.0 3.1 8.3 6.2 0.0 3.4 3 0 0 3 3 3 0 Part of AAA domain AAA_PrkA PF08298.6 CCF31927.1 - 0.14 10.8 0.0 5.9 5.4 0.0 2.2 2 0 0 2 2 2 0 PrkA AAA domain AAA_28 PF13521.1 CCF31927.1 - 0.49 10.3 4.1 54 3.7 1.6 3.2 3 0 0 3 3 3 0 AAA domain Rad17 PF03215.10 CCF31927.1 - 0.56 8.8 0.0 27 3.2 0.0 2.1 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein NB-ARC PF00931.17 CCF31927.1 - 0.74 8.6 0.9 36 3.0 0.0 2.9 2 1 1 3 3 3 0 NB-ARC domain AIG1 PF04548.11 CCF31927.1 - 1.5 7.9 3.2 2.1 7.4 0.5 2.2 2 0 0 2 2 2 0 AIG1 family AAA_13 PF13166.1 CCF31927.1 - 3.2 6.0 0.2 59 1.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain MutS_V PF00488.16 CCF31929.1 - 7.2e-99 329.9 0.1 1e-98 329.4 0.0 1.2 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 CCF31929.1 - 1.7e-40 139.0 0.4 3.4e-40 137.9 0.3 1.6 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.12 CCF31929.1 - 1.1e-22 80.5 0.8 1.2e-21 77.2 0.0 2.7 3 0 0 3 3 3 1 MutS domain II MutS_I PF01624.15 CCF31929.1 - 2.3e-20 72.7 0.0 1e-19 70.6 0.0 2.1 2 0 0 2 2 2 1 MutS domain I MutS_IV PF05190.13 CCF31929.1 - 1e-17 64.0 1.4 1e-17 64.0 1.0 2.2 2 0 0 2 2 2 1 MutS family domain IV tRNA_m1G_MT PF01746.16 CCF31930.1 - 2e-34 118.8 0.0 4.8e-25 88.2 0.0 2.3 2 0 0 2 2 2 2 tRNA (Guanine-1)-methyltransferase DNA_primase_S PF01896.14 CCF31931.1 - 1.1e-53 180.9 0.1 1.7e-53 180.3 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase small subunit Mem_trans PF03547.13 CCF31932.1 - 1.8e-16 59.4 6.0 2.3e-16 59.1 4.1 1.0 1 0 0 1 1 1 1 Membrane transport protein DUF1634 PF07843.6 CCF31932.1 - 0.021 14.4 0.2 0.054 13.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1634) RRM_1 PF00076.17 CCF31933.1 - 6.4e-15 54.5 0.0 8.9e-15 54.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF31933.1 - 3.5e-13 49.3 0.0 5e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF31933.1 - 6e-08 32.4 0.0 8.8e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1777 PF08648.7 CCF31933.1 - 0.00016 21.4 15.7 0.00016 21.4 10.9 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF1777) DUF650 PF04894.7 CCF31933.1 - 0.12 11.7 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Archaeal protein of unknown function (DUF650) RTA1 PF04479.8 CCF31935.1 - 1.1e-35 123.1 6.9 1.7e-35 122.5 4.8 1.2 1 0 0 1 1 1 1 RTA1 like protein DUF4401 PF14351.1 CCF31935.1 - 0.087 11.7 16.3 0.12 11.3 11.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4401) DUF2721 PF11026.3 CCF31935.1 - 2.3 7.8 10.5 3 7.4 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) DUF373 PF04123.8 CCF31935.1 - 4.9 6.0 9.4 12 4.8 6.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF373) Methyltransf_26 PF13659.1 CCF31936.1 - 0.13 12.2 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Pyrophosphatase PF00719.14 CCF31937.1 - 3.8e-38 130.3 0.3 5.6e-38 129.8 0.0 1.4 2 0 0 2 2 2 1 Inorganic pyrophosphatase DUF3237 PF11578.3 CCF31938.1 - 1.7e-28 98.8 0.1 9.8e-28 96.3 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3237) DUF2823 PF11034.3 CCF31939.1 - 3e-30 104.1 10.4 3.3e-30 103.9 7.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2823) DUF3756 PF12581.3 CCF31939.1 - 0.059 13.0 0.3 0.098 12.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3756) Abhydrolase_4 PF08386.5 CCF31941.1 - 2.9e-18 65.6 0.0 7.9e-18 64.2 0.0 1.7 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.15 CCF31941.1 - 5.2e-12 45.8 1.0 1.7e-07 31.0 0.4 3.3 2 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF31941.1 - 7.7e-10 39.0 0.5 6.3e-09 36.0 0.3 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF31941.1 - 0.0018 18.0 0.0 0.21 11.3 0.0 2.4 2 0 0 2 2 2 2 Alpha/beta hydrolase family Aldedh PF00171.17 CCF31942.1 - 4.9e-06 25.1 0.8 5.8e-06 24.9 0.5 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family CPSase_L_D2 PF02786.12 CCF31944.1 - 2.6e-68 229.4 0.0 3.7e-68 228.9 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.14 CCF31944.1 - 1.5e-28 98.8 0.0 2.7e-28 98.0 0.0 1.4 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain ATP-grasp_4 PF13535.1 CCF31944.1 - 1.6e-14 54.0 0.0 3.5e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.17 CCF31944.1 - 1.6e-11 43.8 0.1 3.7e-11 42.6 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 CCF31944.1 - 7.6e-11 41.7 0.3 2.5e-10 40.0 0.2 1.8 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus CPSase_L_chain PF00289.17 CCF31944.1 - 1.3e-08 34.8 0.0 3.7e-08 33.4 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain ATPgrasp_Ter PF15632.1 CCF31944.1 - 6.9e-08 31.5 0.0 1.5e-07 30.4 0.0 1.4 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.9 CCF31944.1 - 7.7e-08 32.3 0.0 1.4e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl PF00364.17 CCF31944.1 - 4.9e-07 29.3 3.1 1.1e-06 28.1 2.0 1.7 1 1 0 1 1 1 1 Biotin-requiring enzyme RimK PF08443.6 CCF31944.1 - 1.4e-05 24.6 0.0 2.4e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain SUI1 PF01253.17 CCF31944.1 - 0.014 15.1 0.0 0.033 13.9 0.0 1.5 1 0 0 1 1 1 0 Translation initiation factor SUI1 DUF3182 PF11379.3 CCF31944.1 - 0.11 11.1 0.0 0.18 10.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3182) Toxin_59 PF15537.1 CCF31944.1 - 0.13 12.3 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Putative toxin 59 Carboxyl_trans PF01039.17 CCF31945.1 - 4.7e-31 107.6 0.0 5.3e-31 107.5 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain Acetyltransf_3 PF13302.1 CCF31946.1 - 1.3e-06 28.6 0.0 1.9e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Amidase PF01425.16 CCF31947.1 - 5.4e-89 299.0 0.0 6.4e-89 298.8 0.0 1.1 1 0 0 1 1 1 1 Amidase Peptidase_S8 PF00082.17 CCF31948.1 - 3e-44 151.2 3.1 5.1e-44 150.5 2.1 1.4 1 0 0 1 1 1 1 Subtilase family DUF1034 PF06280.7 CCF31948.1 - 2.7e-14 53.5 0.5 5.4e-14 52.5 0.4 1.5 1 0 0 1 1 1 1 Fn3-like domain (DUF1034) DUF4066 PF13278.1 CCF31949.1 - 1.6e-10 40.5 0.0 2e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 Putative amidotransferase DJ-1_PfpI PF01965.19 CCF31949.1 - 7.7e-08 31.9 0.0 1e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family SH3_1 PF00018.23 CCF31950.1 - 0.0089 15.4 0.1 0.024 14.0 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 CCF31950.1 - 0.018 14.6 0.5 0.032 13.8 0.3 1.4 1 0 0 1 1 1 0 Variant SH3 domain Isochorismatase PF00857.15 CCF31952.1 - 4e-13 49.6 0.2 4e-13 49.6 0.1 1.1 1 0 0 1 1 1 1 Isochorismatase family Isochorismatase PF00857.15 CCF31953.1 - 5.7e-06 26.3 0.0 7.8e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family ADH_N PF08240.7 CCF31954.1 - 5.1e-27 93.7 2.1 1.1e-26 92.7 1.5 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF31954.1 - 9.8e-16 57.4 0.1 1.5e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase S1-like PF14444.1 CCF31954.1 - 0.021 14.5 0.1 0.34 10.6 0.0 2.5 2 0 0 2 2 2 0 S1-like ATP-synt_G PF04718.10 CCF31955.1 - 9.4e-23 80.8 0.0 1.9e-22 79.8 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit DDE_1 PF03184.14 CCF31956.1 - 2.2e-49 167.5 0.0 3.5e-49 166.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 CCF31956.1 - 6.7e-12 45.0 0.2 1.6e-11 43.8 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF31956.1 - 1e-11 44.1 0.2 1.9e-11 43.3 0.2 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.1 CCF31956.1 - 2.2e-07 30.7 0.0 4.7e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_28 PF13518.1 CCF31956.1 - 0.00067 19.6 1.0 0.0016 18.3 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 CCF31956.1 - 0.0019 17.7 0.1 0.0057 16.2 0.1 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.10 CCF31956.1 - 0.0082 15.9 0.6 0.016 15.0 0.4 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_Tnp_IS630 PF01710.11 CCF31956.1 - 0.017 14.7 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 Transposase HTH_29 PF13551.1 CCF31956.1 - 0.019 15.0 0.5 0.052 13.6 0.4 1.8 1 1 0 1 1 1 0 Winged helix-turn helix HTH_8 PF02954.14 CCF31956.1 - 0.022 14.3 0.1 0.062 12.8 0.1 1.8 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_Tnp_1 PF01527.15 CCF31956.1 - 0.11 12.4 0.2 0.39 10.7 0.0 2.0 3 0 0 3 3 3 0 Transposase Bclx_interact PF08945.5 CCF31957.1 - 0.03 13.8 0.6 1 8.9 0.2 2.3 2 0 0 2 2 2 0 Bcl-x interacting, BH3 domain RNHCP PF12647.2 CCF31957.1 - 0.36 10.6 3.7 0.63 9.8 2.5 1.6 1 1 0 1 1 1 0 RNHCP domain Clp1 PF06807.9 CCF31958.1 - 8.8e-10 38.6 0.0 7.8e-09 35.5 0.0 2.2 1 1 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 MobB PF03205.9 CCF31958.1 - 0.0014 18.3 0.0 0.0034 17.0 0.0 1.6 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B RNA_polI_A34 PF08208.6 CCF31960.1 - 1.1e-29 103.5 3.6 1.1e-29 103.5 2.5 6.4 3 2 3 6 6 6 1 DNA-directed RNA polymerase I subunit RPA34.5 Peptidase_M3 PF01432.15 CCF31961.1 - 2.9e-105 352.9 0.0 3.3e-105 352.7 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M3 Cir_N PF10197.4 CCF31962.1 - 1.6e-06 28.0 2.0 2.2e-06 27.6 1.4 1.2 1 0 0 1 1 1 1 N-terminal domain of CBF1 interacting co-repressor CIR ERM PF00769.14 CCF31962.1 - 0.017 14.6 1.8 0.019 14.5 1.3 1.0 1 0 0 1 1 1 0 Ezrin/radixin/moesin family AAA PF00004.24 CCF31963.1 - 8.7e-48 161.8 0.0 7.4e-38 129.7 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 CCF31963.1 - 9.3e-12 44.9 0.0 4.2e-07 29.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 CCF31963.1 - 2e-08 34.4 0.1 0.0018 18.4 0.0 4.1 2 2 0 2 2 2 2 AAA domain TIP49 PF06068.8 CCF31963.1 - 1.7e-07 30.3 0.0 0.016 13.9 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus AAA_17 PF13207.1 CCF31963.1 - 1.6e-06 28.9 0.0 0.0065 17.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.9 CCF31963.1 - 3e-06 27.2 0.0 4e-05 23.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 CCF31963.1 - 3.7e-06 26.7 0.0 0.0016 18.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 CCF31963.1 - 1e-05 25.2 0.3 0.034 13.9 0.0 2.6 2 0 0 2 2 2 2 Part of AAA domain AAA_18 PF13238.1 CCF31963.1 - 1.3e-05 25.4 0.0 0.0035 17.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 CCF31963.1 - 2.2e-05 23.6 0.1 0.0035 16.5 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.1 CCF31963.1 - 7.5e-05 22.7 0.1 0.053 13.5 0.0 2.7 2 1 1 3 3 2 1 AAA ATPase domain RuvB_N PF05496.7 CCF31963.1 - 8.3e-05 21.7 0.1 0.058 12.4 0.0 3.1 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus RNA_helicase PF00910.17 CCF31963.1 - 0.00011 22.2 0.0 0.23 11.6 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_33 PF13671.1 CCF31963.1 - 0.00014 21.7 0.0 0.18 11.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain CDC48_N PF02359.13 CCF31963.1 - 0.00026 20.8 0.0 0.00075 19.4 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_25 PF13481.1 CCF31963.1 - 0.00028 20.3 0.9 0.64 9.3 0.0 3.5 2 2 1 4 4 4 1 AAA domain Arch_ATPase PF01637.13 CCF31963.1 - 0.00034 20.3 0.9 4.5 6.9 0.1 4.0 2 2 1 3 3 3 1 Archaeal ATPase NB-ARC PF00931.17 CCF31963.1 - 0.00059 18.7 0.1 0.74 8.6 0.0 3.0 3 0 0 3 3 3 1 NB-ARC domain IstB_IS21 PF01695.12 CCF31963.1 - 0.00081 18.8 0.2 0.023 14.1 0.0 2.7 3 0 0 3 3 3 1 IstB-like ATP binding protein KaiC PF06745.8 CCF31963.1 - 0.0013 17.9 0.2 0.11 11.6 0.1 2.6 2 1 0 2 2 2 1 KaiC Zeta_toxin PF06414.7 CCF31963.1 - 0.0033 16.5 0.0 0.23 10.5 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin Sigma54_activat PF00158.21 CCF31963.1 - 0.0065 15.9 0.0 0.62 9.5 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain KTI12 PF08433.5 CCF31963.1 - 0.0073 15.5 0.0 0.47 9.6 0.0 2.4 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_11 PF13086.1 CCF31963.1 - 0.0082 15.7 0.0 1.1 8.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.22 CCF31963.1 - 0.01 16.1 0.1 0.048 13.9 0.1 2.2 2 0 0 2 2 1 0 ABC transporter AAA_28 PF13521.1 CCF31963.1 - 0.013 15.5 0.0 0.48 10.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain CPT PF07931.7 CCF31963.1 - 0.013 15.1 0.0 0.18 11.3 0.0 2.4 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_24 PF13479.1 CCF31963.1 - 0.027 14.0 0.0 0.7 9.4 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.6 CCF31963.1 - 0.034 13.7 0.1 0.36 10.4 0.0 2.5 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.11 CCF31963.1 - 0.051 12.7 0.0 0.72 9.0 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein Parvo_NS1 PF01057.12 CCF31963.1 - 0.061 12.1 0.0 1.3 7.8 0.0 2.1 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 NACHT PF05729.7 CCF31963.1 - 0.062 12.9 0.0 13 5.4 0.0 2.8 3 0 0 3 3 3 0 NACHT domain UPF0079 PF02367.12 CCF31963.1 - 0.13 11.9 0.0 1.2 8.7 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 ubiquitin PF00240.18 CCF31964.1 - 0.00047 19.4 0.0 0.0007 18.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family YukD PF08817.5 CCF31964.1 - 0.011 16.2 0.0 0.018 15.5 0.0 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD DUF1923 PF09083.5 CCF31964.1 - 0.1 12.0 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1923) Pro-rich PF15240.1 CCF31964.1 - 0.72 9.9 11.3 0.98 9.4 7.9 1.1 1 0 0 1 1 1 0 Proline-rich DNA_binding_1 PF01035.15 CCF31965.1 - 5.5e-26 90.1 0.0 7.3e-26 89.7 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain FAD_binding_4 PF01565.18 CCF31967.1 - 4.7e-16 58.5 1.5 4.7e-16 58.5 1.0 1.7 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.7 CCF31967.1 - 1.3e-13 50.6 0.6 1.3e-13 50.6 0.4 1.9 2 0 0 2 2 2 1 Berberine and berberine like Cytokin-bind PF09265.5 CCF31967.1 - 0.13 11.3 0.1 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding ARGLU PF15346.1 CCF31969.1 - 0.031 14.0 8.5 0.1 12.3 5.9 1.9 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 DUF4404 PF14357.1 CCF31969.1 - 5.5 7.4 11.7 9.4 6.7 4.0 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) AAA_23 PF13476.1 CCF31969.1 - 5.9 7.1 12.3 10 6.3 8.5 1.3 1 0 0 1 1 1 0 AAA domain PNP_UDP_1 PF01048.15 CCF31970.1 - 7.9e-10 38.1 0.1 1.5e-09 37.2 0.1 1.4 1 1 0 1 1 1 1 Phosphorylase superfamily Polyketide_cyc2 PF10604.4 CCF31971.1 - 6.4e-08 32.8 0.3 7.1e-08 32.7 0.2 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Amidase_6 PF12671.2 CCF31971.1 - 0.046 13.7 0.4 0.054 13.5 0.3 1.2 1 0 0 1 1 1 0 Putative amidase domain DUF4520 PF15016.1 CCF31971.1 - 0.046 13.2 0.0 0.081 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4520) FAD_binding_3 PF01494.14 CCF31972.1 - 3.5e-82 276.2 0.0 5.1e-82 275.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.7 CCF31972.1 - 9.7e-39 132.6 0.0 1.6e-38 131.9 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Thi4 PF01946.12 CCF31972.1 - 0.00044 19.4 0.0 0.00077 18.6 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.19 CCF31972.1 - 0.00046 19.1 0.1 0.0013 17.6 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.19 CCF31972.1 - 0.0016 17.3 0.8 0.008 15.1 0.2 2.0 1 1 1 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 CCF31972.1 - 0.0036 16.4 0.2 0.0059 15.7 0.2 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase SE PF08491.5 CCF31972.1 - 0.0091 14.8 0.0 0.046 12.5 0.0 1.8 1 1 0 1 1 1 1 Squalene epoxidase Tagatose_6_P_K PF08013.6 CCF31972.1 - 0.012 14.0 0.0 0.019 13.4 0.0 1.1 1 0 0 1 1 1 0 Tagatose 6 phosphate kinase NAD_binding_8 PF13450.1 CCF31972.1 - 0.078 13.0 0.2 0.22 11.5 0.1 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.16 CCF31972.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.9 CCF31972.1 - 0.1 12.4 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.11 CCF31972.1 - 0.15 11.5 0.4 0.39 10.1 0.1 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA SSF PF00474.12 CCF31973.1 - 2.3e-17 62.7 18.5 5.5e-17 61.5 12.9 1.6 1 1 0 1 1 1 1 Sodium:solute symporter family LysM PF01476.15 CCF31974.1 - 5.1e-21 74.3 0.1 1.4e-09 37.6 0.0 2.2 2 0 0 2 2 2 2 LysM domain F-box-like PF12937.2 CCF31976.1 - 7.6e-10 38.3 0.5 1.4e-09 37.4 0.3 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF31976.1 - 1.9e-06 27.3 0.7 4.3e-06 26.2 0.5 1.6 1 0 0 1 1 1 1 F-box domain Myosin_head PF00063.16 CCF31977.1 - 1.8e-47 161.8 0.1 2e-47 161.6 0.1 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.1 CCF31977.1 - 0.00069 19.7 0.0 0.0015 18.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 CCF31977.1 - 0.0021 17.1 0.0 0.0035 16.4 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_17 PF13207.1 CCF31977.1 - 0.011 16.5 0.2 0.029 15.1 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 CCF31977.1 - 0.015 15.0 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain NACHT PF05729.7 CCF31977.1 - 0.017 14.7 0.0 0.027 14.1 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Sigma54_activat PF00158.21 CCF31977.1 - 0.022 14.2 0.0 0.035 13.5 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.1 CCF31977.1 - 0.029 14.3 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.1 CCF31977.1 - 0.03 14.6 0.3 0.095 13.0 0.1 1.8 2 0 0 2 2 2 0 AAA domain DUF552 PF04472.7 CCF31977.1 - 0.034 14.0 0.1 0.067 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF552) RNA_helicase PF00910.17 CCF31977.1 - 0.037 14.2 0.1 0.11 12.7 0.0 1.8 1 0 0 1 1 1 0 RNA helicase UPF0079 PF02367.12 CCF31977.1 - 0.042 13.4 0.0 0.065 12.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_30 PF13604.1 CCF31977.1 - 0.062 12.8 0.0 0.096 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 CCF31977.1 - 0.075 12.2 0.1 1.1 8.4 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein DUF258 PF03193.11 CCF31977.1 - 0.082 12.0 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ABC_tran PF00005.22 CCF31977.1 - 0.09 13.0 0.1 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Hpr_kinase_C PF07475.7 CCF31977.1 - 0.11 11.7 0.1 0.4 9.9 0.0 1.7 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain Mg_chelatase PF01078.16 CCF31977.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TrwB_AAD_bind PF10412.4 CCF31977.1 - 0.12 10.9 0.0 0.17 10.5 0.0 1.1 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain His_Phos_2 PF00328.17 CCF31980.1 - 1.2e-12 47.8 0.2 1.7e-10 40.8 0.1 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF3336 PF11815.3 CCF31982.1 - 7.7e-39 132.5 0.5 1.7e-38 131.4 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 CCF31982.1 - 6.8e-24 84.9 0.0 1.5e-23 83.7 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase Abhydrolase_6 PF12697.2 CCF31983.1 - 0.0032 17.3 0.1 0.017 15.0 0.0 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF31983.1 - 0.0092 15.7 0.3 0.15 11.8 0.2 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Adeno_PIX PF03955.9 CCF31983.1 - 0.055 13.9 1.3 0.23 12.0 0.0 2.5 2 1 0 3 3 3 0 Adenovirus hexon-associated protein (IX) Arylesterase PF01731.15 CCF31984.1 - 0.00061 19.7 0.0 0.0051 16.7 0.0 2.4 1 1 0 1 1 1 1 Arylesterase Abi_C PF14355.1 CCF31984.1 - 0.044 13.7 0.1 0.099 12.5 0.1 1.5 1 0 0 1 1 1 0 Abortive infection C-terminus Fungal_trans PF04082.13 CCF31985.1 - 1.7e-08 33.6 0.3 2.7e-08 32.9 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Complex1_LYR PF05347.10 CCF31986.1 - 0.00015 21.4 3.1 0.00015 21.4 2.2 2.3 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 CCF31986.1 - 0.022 14.9 6.7 0.022 14.9 4.7 2.7 2 1 0 2 2 2 0 Complex1_LYR-like Acetyltransf_1 PF00583.19 CCF31987.1 - 1.3e-13 50.7 0.1 1.9e-13 50.2 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 CCF31987.1 - 1.5e-08 34.2 0.0 2.6e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.1 CCF31987.1 - 3.5e-07 30.2 0.0 5.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CCF31987.1 - 8.4e-05 22.6 0.0 0.00011 22.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 CCF31987.1 - 0.00054 20.1 0.0 0.00083 19.5 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 CCF31987.1 - 0.035 14.0 0.0 0.12 12.2 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF3749 PF12568.3 CCF31987.1 - 0.083 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF4349 PF14257.1 CCF31987.1 - 0.089 12.0 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) 2-Hacid_dh_C PF02826.14 CCF31988.1 - 1.5e-40 138.2 0.0 1.4e-26 92.7 0.0 2.1 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 CCF31988.1 - 0.12 12.0 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MFS_1 PF07690.11 CCF31989.1 - 4.8e-21 74.8 39.1 2.6e-20 72.4 22.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Utp14 PF04615.8 CCF31990.1 - 0.36 8.9 27.3 0.44 8.6 18.9 1.0 1 0 0 1 1 1 0 Utp14 protein SAPS PF04499.10 CCF31990.1 - 1.3 7.6 10.5 1.4 7.5 7.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF1510 PF07423.6 CCF31990.1 - 1.4 8.2 24.2 2 7.7 16.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF3807 PF12720.2 CCF31990.1 - 2.1 8.4 20.4 3.6 7.7 14.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Daxx PF03344.10 CCF31990.1 - 3.6 5.9 16.8 4 5.7 11.6 1.0 1 0 0 1 1 1 0 Daxx Family Parvo_coat PF00740.13 CCF31990.1 - 5.9 5.7 14.2 7.2 5.4 9.9 1.1 1 0 0 1 1 1 0 Parvovirus coat protein VP2 Hid1 PF12722.2 CCF31990.1 - 9 3.8 13.7 10 3.6 9.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein E1_dh PF00676.15 CCF31991.1 - 3.2e-111 370.8 0.3 4e-111 370.5 0.2 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 CCF31991.1 - 0.0022 16.9 0.1 0.0042 16.0 0.0 1.5 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase WD40 PF00400.27 CCF31992.1 - 5.3e-18 64.1 0.9 4.3e-08 32.7 0.1 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat Nucleoporin_N PF08801.6 CCF31992.1 - 0.016 14.0 0.0 0.019 13.7 0.0 1.2 1 0 0 1 1 1 0 Nup133 N terminal like Nup160 PF11715.3 CCF31992.1 - 0.019 13.1 0.2 0.78 7.7 0.1 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 PQQ_3 PF13570.1 CCF31992.1 - 0.02 15.1 0.6 21 5.5 0.0 3.6 5 0 0 5 5 5 0 PQQ-like domain PQQ_2 PF13360.1 CCF31992.1 - 0.055 12.9 0.3 4.6 6.6 0.0 2.5 1 1 1 2 2 2 0 PQQ-like domain F-box-like PF12937.2 CCF31993.1 - 4.4e-13 48.7 0.9 9.2e-13 47.6 0.6 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF31993.1 - 1.9e-06 27.3 2.5 3.6e-06 26.4 1.7 1.5 1 0 0 1 1 1 1 F-box domain WD40 PF00400.27 CCF31993.1 - 1.1e-05 25.0 0.0 0.00015 21.4 0.0 2.7 3 0 0 3 3 3 1 WD domain, G-beta repeat F-box-like_2 PF13013.1 CCF31993.1 - 0.0069 16.0 0.0 0.018 14.7 0.0 1.6 1 1 0 1 1 1 1 F-box-like domain Nol1_Nop2_Fmu PF01189.12 CCF31994.1 - 1.7e-76 257.3 0.0 2.6e-76 256.6 0.0 1.2 1 0 0 1 1 1 1 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 CCF31994.1 - 4.2e-05 23.5 0.3 0.00049 20.1 0.0 2.7 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF31994.1 - 0.00091 18.8 0.0 0.0015 18.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF31994.1 - 0.001 19.6 0.1 0.0052 17.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 CCF31994.1 - 0.0024 17.8 0.0 0.0045 17.0 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.14 CCF31994.1 - 0.0072 15.8 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) XRCC4 PF06632.7 CCF31996.1 - 2.9e-07 29.6 17.8 2.4e-06 26.6 12.4 1.9 1 1 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 Spc7 PF08317.6 CCF31996.1 - 0.23 10.1 5.8 0.34 9.5 4.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Mnd1 PF03962.10 CCF31996.1 - 1.7 8.3 11.5 0.051 13.2 3.4 1.7 2 0 0 2 2 2 0 Mnd1 family Metal_resist PF13801.1 CCF31996.1 - 2.5 8.0 13.2 2.7 8.0 7.9 2.0 1 1 1 2 2 2 0 Heavy-metal resistance WBS_methylT PF12589.3 CCF31996.1 - 6.9 7.2 8.8 10 6.7 0.1 2.5 2 0 0 2 2 2 0 Methyltransferase involved in Williams-Beuren syndrome Aldo_ket_red PF00248.16 CCF31997.1 - 1.9e-50 171.3 0.0 2.2e-50 171.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family UPF0061 PF02696.9 CCF31998.1 - 8.1e-124 413.5 0.0 1e-123 413.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Molybdopterin PF00384.17 CCF31999.1 - 4.2e-75 253.1 0.0 2.4e-73 247.3 0.0 2.1 1 1 0 1 1 1 1 Molybdopterin oxidoreductase NADH-G_4Fe-4S_3 PF10588.4 CCF31999.1 - 1.6e-18 65.6 0.1 4.6e-18 64.1 0.1 1.8 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region DUF1982 PF09326.6 CCF31999.1 - 5.4e-15 55.2 0.0 1.5e-14 53.8 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1982) Fer2_4 PF13510.1 CCF31999.1 - 8.9e-15 54.2 0.2 2.8e-14 52.6 0.1 1.9 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2 PF00111.22 CCF31999.1 - 0.0001 21.9 2.7 0.0001 21.9 0.2 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.17 CCF31999.1 - 0.0066 16.2 0.0 0.17 11.6 0.0 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.22 CCF31999.1 - 0.11 12.1 1.1 3.1 7.5 0.2 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_19 PF06902.6 CCF31999.1 - 0.26 11.1 2.0 3 7.7 1.4 2.4 1 1 0 1 1 1 0 Divergent 4Fe-4S mono-cluster Fer4_6 PF12837.2 CCF31999.1 - 0.36 10.7 3.2 0.46 10.4 0.9 2.1 2 0 0 2 2 2 0 4Fe-4S binding domain RRM_1 PF00076.17 CCF32001.1 - 5.7e-19 67.5 0.0 8.1e-19 67.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF32001.1 - 1.5e-15 56.9 0.0 2.2e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF32001.1 - 6.7e-07 29.0 0.0 9.2e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 CCF32001.1 - 0.14 12.0 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 RNA binding motif SRP14 PF02290.10 CCF32002.1 - 1.7e-22 79.1 0.0 2.6e-22 78.5 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle 14kD protein MIF4G PF02854.14 CCF32003.1 - 2.7e-22 79.2 0.0 6.7e-21 74.6 0.0 2.2 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.12 CCF32003.1 - 4.4e-11 42.4 0.0 1.7e-10 40.5 0.0 2.1 1 0 0 1 1 1 1 MA3 domain Sporozoite_P67 PF05642.6 CCF32003.1 - 2.3 5.9 11.5 3.8 5.2 8.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pyr_redox_dim PF02852.17 CCF32004.1 - 5.1e-40 135.9 0.1 1.7e-39 134.2 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.9 CCF32004.1 - 1.4e-38 132.8 14.0 1.6e-28 99.9 1.5 4.0 1 1 2 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF32004.1 - 9.3e-25 86.8 11.9 3.1e-21 75.5 0.8 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF32004.1 - 2.4e-11 43.5 3.1 4.4e-06 26.6 0.3 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF32004.1 - 3e-10 40.4 1.0 3.3e-05 24.0 0.4 2.5 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 CCF32004.1 - 3.5e-10 39.5 8.0 1.2e-09 37.8 0.2 2.5 2 1 1 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.17 CCF32004.1 - 2.8e-09 36.3 13.6 5.8e-08 31.9 3.0 2.8 2 2 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.19 CCF32004.1 - 1.1e-08 34.3 9.5 3.2e-07 29.5 2.3 2.9 3 0 0 3 3 3 2 FAD binding domain DAO PF01266.19 CCF32004.1 - 1.3e-08 34.1 19.3 0.0001 21.3 0.7 4.2 3 1 1 4 4 4 3 FAD dependent oxidoreductase Thi4 PF01946.12 CCF32004.1 - 4.7e-07 29.1 4.2 0.0001 21.4 0.2 2.4 2 0 0 2 2 2 2 Thi4 family HI0933_like PF03486.9 CCF32004.1 - 4.9e-07 28.5 13.2 4.1e-05 22.2 1.1 4.1 4 0 0 4 4 4 2 HI0933-like protein K_oxygenase PF13434.1 CCF32004.1 - 2.6e-05 23.3 0.2 0.22 10.3 0.0 2.8 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) AlaDh_PNT_C PF01262.16 CCF32004.1 - 7.9e-05 22.2 2.4 0.21 11.1 0.1 2.7 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.7 CCF32004.1 - 0.00021 20.3 1.8 0.0084 15.0 0.0 2.5 3 0 0 3 3 3 1 Lycopene cyclase protein FAD_binding_3 PF01494.14 CCF32004.1 - 0.0056 15.7 11.2 0.25 10.3 1.0 3.3 3 1 0 3 3 3 2 FAD binding domain Amino_oxidase PF01593.19 CCF32004.1 - 0.01 14.9 0.0 0.02 14.0 0.0 1.4 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase 3HCDH_N PF02737.13 CCF32004.1 - 0.033 13.8 8.7 0.031 13.9 0.7 2.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FMO-like PF00743.14 CCF32004.1 - 0.087 11.0 0.6 0.16 10.1 0.4 1.4 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Trp_halogenase PF04820.9 CCF32004.1 - 0.18 10.3 6.4 0.12 10.9 0.5 2.2 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_7 PF13241.1 CCF32004.1 - 0.29 11.4 7.6 7.5 6.8 0.5 3.1 2 2 0 3 3 3 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.9 CCF32004.1 - 1.6 8.1 5.7 3.2 7.1 0.2 2.4 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Tyrosinase PF00264.15 CCF32005.1 - 6.5e-37 127.8 0.3 4.8e-36 124.9 0.2 2.1 1 1 0 1 1 1 1 Common central domain of tyrosinase Abhydrolase_1 PF00561.15 CCF32006.1 - 4.4e-19 68.9 0.0 8e-18 64.8 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.5 CCF32006.1 - 4.7e-16 58.5 0.0 1e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_6 PF12697.2 CCF32006.1 - 4.1e-11 43.2 0.0 1e-10 41.9 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF32006.1 - 0.0039 16.9 0.1 0.028 14.1 0.1 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 CCF32007.1 - 4.6e-30 104.7 0.0 7.4e-30 104.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 CCF32007.1 - 6e-08 31.8 0.0 3.1e-07 29.4 0.0 1.8 2 0 0 2 2 2 1 Carboxylesterase family AXE1 PF05448.7 CCF32007.1 - 0.00017 20.1 0.0 0.00043 18.8 0.0 1.6 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.16 CCF32007.1 - 0.00099 18.3 0.0 0.0017 17.6 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 CCF32007.1 - 0.0023 17.8 0.0 0.0039 17.0 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF32007.1 - 0.0087 15.8 0.0 0.017 14.8 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 CCF32007.1 - 0.08 13.1 0.0 0.17 12.0 0.0 1.6 1 1 1 2 2 2 0 Thioesterase domain DUF2424 PF10340.4 CCF32007.1 - 0.09 11.3 0.1 0.23 10.0 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2424) AAA PF00004.24 CCF32008.1 - 7.8e-17 61.7 0.0 1.5e-16 60.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CCF32008.1 - 0.0018 17.9 0.0 0.0052 16.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 CCF32008.1 - 0.0041 17.9 0.1 0.023 15.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CCF32008.1 - 0.0073 16.4 0.2 0.038 14.1 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.1 CCF32008.1 - 0.014 15.3 0.0 0.063 13.2 0.0 2.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.1 CCF32008.1 - 0.045 13.5 0.1 0.15 11.8 0.1 1.9 1 0 0 1 1 1 0 Part of AAA domain AAA_18 PF13238.1 CCF32008.1 - 0.097 12.9 0.0 0.3 11.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 CCF32008.1 - 0.15 11.5 0.7 0.33 10.4 0.1 1.8 2 0 0 2 2 2 0 AAA domain HSP70 PF00012.15 CCF32009.1 - 1e-09 36.9 5.7 1.2e-09 36.6 4.0 1.0 1 0 0 1 1 1 1 Hsp70 protein NigD PF12667.2 CCF32009.1 - 0.051 13.3 0.1 0.062 13.0 0.1 1.1 1 0 0 1 1 1 0 NigD-like protein Erythro_esteras PF05139.9 CCF32009.1 - 0.09 11.9 2.8 0.1 11.7 2.0 1.1 1 0 0 1 1 1 0 Erythromycin esterase DUF4363 PF14276.1 CCF32009.1 - 0.11 12.1 1.0 0.16 11.7 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) Lipoprotein_6 PF01441.14 CCF32009.1 - 0.5 10.1 10.3 0.14 11.9 0.8 2.0 1 1 1 2 2 2 0 Lipoprotein DUF4175 PF13779.1 CCF32009.1 - 0.59 7.7 7.3 0.69 7.5 5.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) UVR PF02151.14 CCF32009.1 - 0.6 9.7 5.1 0.26 10.8 1.3 2.2 2 0 0 2 2 2 0 UvrB/uvrC motif OmpH PF03938.9 CCF32009.1 - 3.2 7.6 7.6 4.4 7.2 5.2 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) PMEI PF04043.10 CCF32010.1 - 0.056 13.3 0.5 0.056 13.3 0.4 2.5 3 1 0 3 3 3 0 Plant invertase/pectin methylesterase inhibitor PPR PF01535.15 CCF32011.1 - 1.5e-11 43.4 1.4 0.0025 17.6 0.1 7.2 8 0 0 8 8 8 3 PPR repeat PPR_2 PF13041.1 CCF32011.1 - 6.7e-11 41.9 0.1 0.16 11.9 0.0 6.6 7 1 1 8 8 8 3 PPR repeat family PPR_3 PF13812.1 CCF32011.1 - 1.6e-08 34.1 12.2 0.0039 17.3 0.0 8.0 9 0 0 9 9 9 2 Pentatricopeptide repeat domain PPR_1 PF12854.2 CCF32011.1 - 1.3e-07 30.9 0.8 0.07 12.6 0.0 4.4 4 0 0 4 4 4 3 PPR repeat TPR_14 PF13428.1 CCF32011.1 - 0.00014 22.1 15.4 2.4 9.0 0.0 8.0 8 1 0 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.1 CCF32011.1 - 0.022 15.0 9.9 0.093 13.0 0.0 5.5 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.1 CCF32011.1 - 0.65 10.7 9.1 21 5.9 0.2 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 CCF32011.1 - 4.5 7.4 12.0 7.3 6.7 0.0 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat Cutinase PF01083.17 CCF32012.1 - 1.8e-43 148.3 0.0 2.4e-43 147.9 0.0 1.2 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.6 CCF32012.1 - 0.001 18.5 0.0 0.002 17.6 0.0 1.5 1 0 0 1 1 1 1 PE-PPE domain DUF2974 PF11187.3 CCF32012.1 - 0.0018 17.7 0.0 0.0029 17.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Lipase_3 PF01764.20 CCF32012.1 - 0.0078 15.8 0.1 0.014 15.0 0.1 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 CCF32012.1 - 0.072 12.8 0.1 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_8 PF06259.7 CCF32012.1 - 0.082 12.4 0.2 0.17 11.4 0.2 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase VirJ PF06057.6 CCF32012.1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Ribosomal_60s PF00428.14 CCF32013.1 - 0.68 10.3 9.3 2.5 8.5 4.2 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Cnl2_NKP2 PF09447.5 CCF32014.1 - 1.1e-22 79.5 0.2 2.6e-22 78.2 0.1 1.7 1 0 0 1 1 1 1 Cnl2/NKP2 family protein DUF2365 PF10157.4 CCF32014.1 - 0.00078 19.3 0.2 0.0015 18.4 0.1 1.5 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2365) Snf7 PF03357.16 CCF32014.1 - 0.007 15.7 0.2 0.44 9.9 0.1 2.2 2 0 0 2 2 2 1 Snf7 Prefoldin_2 PF01920.15 CCF32014.1 - 0.018 14.7 3.1 0.023 14.4 0.5 2.0 1 1 0 2 2 2 0 Prefoldin subunit Cep57_MT_bd PF06657.8 CCF32014.1 - 0.021 14.7 1.0 3.4 7.6 0.1 2.7 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Peptidase_M75 PF09375.5 CCF32014.1 - 0.025 13.9 0.5 0.07 12.4 0.0 1.6 1 1 0 1 1 1 0 Imelysin DUF4618 PF15397.1 CCF32014.1 - 0.035 13.4 0.5 1.7 7.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) RGCC PF15151.1 CCF32014.1 - 0.037 14.4 0.2 0.084 13.3 0.1 1.6 1 1 0 1 1 1 0 Response gene to complement 32 protein family DASH_Spc19 PF08287.6 CCF32014.1 - 0.041 13.5 0.5 0.041 13.5 0.3 2.0 1 1 0 1 1 1 0 Spc19 TMCO5 PF14992.1 CCF32014.1 - 0.044 12.9 3.6 0.062 12.4 1.2 1.9 1 1 1 2 2 2 0 TMCO5 family DUF1843 PF08898.5 CCF32014.1 - 0.049 13.6 1.1 0.14 12.1 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) Herpes_BLRF2 PF05812.7 CCF32014.1 - 0.061 13.1 1.3 0.13 12.0 0.1 2.0 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein DivIC PF04977.10 CCF32014.1 - 0.1 12.0 4.0 0.9 9.0 0.1 2.3 2 0 0 2 2 2 0 Septum formation initiator SlyX PF04102.7 CCF32014.1 - 0.18 12.1 3.0 1.8 8.9 0.1 2.4 2 0 0 2 2 2 0 SlyX V_ATPase_I PF01496.14 CCF32014.1 - 0.21 9.4 0.8 0.25 9.1 0.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Viral_P18 PF04521.8 CCF32014.1 - 0.23 10.8 3.8 0.73 9.2 0.1 2.2 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein PspA_IM30 PF04012.7 CCF32014.1 - 0.43 9.8 9.3 0.41 9.9 0.4 2.1 1 1 0 2 2 2 0 PspA/IM30 family TMF_DNA_bd PF12329.3 CCF32014.1 - 0.52 10.1 4.4 0.9 9.3 0.3 2.3 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Phage_Gp19 PF09355.5 CCF32014.1 - 1.1 9.1 3.8 1.5 8.7 0.6 2.0 1 1 0 2 2 2 0 Phage protein Gp19/Gp15/Gp42 Tudor-knot PF11717.3 CCF32016.1 - 4.1e-09 36.0 0.8 5.8e-09 35.5 0.2 1.5 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Chromo PF00385.19 CCF32016.1 - 0.0021 17.6 0.3 0.0034 17.0 0.2 1.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain MRG PF05712.8 CCF32017.1 - 9.5e-50 168.2 0.2 1.1e-49 167.9 0.2 1.0 1 0 0 1 1 1 1 MRG Ribosomal_L30 PF00327.15 CCF32018.1 - 2.5e-16 59.0 0.0 3.2e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e CN_hydrolase PF00795.17 CCF32019.1 - 4.9e-07 29.2 0.0 5.1e-05 22.7 0.0 2.1 1 1 1 2 2 2 2 Carbon-nitrogen hydrolase Fungal_trans PF04082.13 CCF32020.1 - 4.2e-39 133.9 0.0 8.4e-39 133.0 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF32021.1 - 1.8e-10 40.5 12.9 3.4e-10 39.6 9.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Clusterin PF01093.12 CCF32021.1 - 0.044 12.5 5.5 0.071 11.9 3.8 1.2 1 0 0 1 1 1 0 Clusterin PAP_PilO PF06864.7 CCF32021.1 - 0.051 11.9 0.1 0.095 11.0 0.1 1.3 1 0 0 1 1 1 0 Pilin accessory protein (PilO) Crystall_2 PF09076.5 CCF32022.1 - 0.0006 19.5 0.3 0.0036 17.0 0.1 2.3 2 1 0 2 2 2 1 Beta/Gamma crystallin Kinesin PF00225.18 CCF32025.1 - 2.1e-105 352.1 1.8 2.1e-105 352.1 1.2 1.6 2 0 0 2 2 2 1 Kinesin motor domain WEMBL PF05701.6 CCF32025.1 - 0.00088 17.8 40.8 0.033 12.6 28.3 2.4 1 1 0 1 1 1 1 Weak chloroplast movement under blue light TRCF PF03461.10 CCF32025.1 - 0.005 16.7 1.1 0.02 14.8 0.2 2.4 1 1 1 2 2 2 1 TRCF domain Striatin PF08232.7 CCF32025.1 - 0.01 16.1 8.5 0.01 16.1 5.9 3.7 2 1 2 4 4 4 0 Striatin family Reo_sigmaC PF04582.7 CCF32025.1 - 0.1 11.7 8.4 0.67 9.0 1.5 2.8 1 1 2 3 3 3 0 Reovirus sigma C capsid protein CENP-F_leu_zip PF10473.4 CCF32025.1 - 3.8 7.3 46.7 0.14 12.0 10.5 4.4 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 LPP PF04728.8 CCF32025.1 - 4.8 7.0 7.0 0.43 10.3 0.1 2.8 3 0 0 3 3 3 0 Lipoprotein leucine-zipper bZIP_1 PF00170.16 CCF32025.1 - 5.5 7.0 23.0 0.54 10.2 0.2 4.9 3 2 2 5 5 5 0 bZIP transcription factor IMS PF00817.15 CCF32028.1 - 3.3e-15 56.1 0.0 3.6e-15 56.0 0.0 1.0 1 0 0 1 1 1 1 impB/mucB/samB family CUE PF02845.11 CCF32028.1 - 0.013 14.9 1.0 0.31 10.5 0.0 2.7 3 0 0 3 3 3 0 CUE domain Carb_anhydrase PF00194.16 CCF32029.1 - 4.1e-05 22.6 0.0 5.6e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase adh_short PF00106.20 CCF32030.1 - 1.1e-06 28.6 0.0 2.3e-06 27.6 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 CCF32030.1 - 0.0028 17.3 0.0 0.005 16.5 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF32030.1 - 0.074 13.0 0.0 0.17 11.8 0.0 1.6 2 0 0 2 2 2 0 NADH(P)-binding LysM PF01476.15 CCF32032.1 - 0.00085 19.1 0.0 0.89 9.4 0.0 2.6 2 0 0 2 2 2 2 LysM domain Glyco_hydro_18 PF00704.23 CCF32032.1 - 0.007 15.8 0.0 0.0094 15.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 APH PF01636.18 CCF32033.1 - 9.4e-11 41.8 0.0 5.1e-10 39.4 0.0 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CCF32033.1 - 2.9e-06 27.0 0.0 4.3e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.6 CCF32033.1 - 0.0015 17.2 0.0 0.0021 16.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) RIO1 PF01163.17 CCF32033.1 - 0.019 14.2 0.0 5.6 6.2 0.0 2.1 2 0 0 2 2 2 0 RIO1 family Fructosamin_kin PF03881.9 CCF32033.1 - 0.025 13.5 0.0 0.81 8.6 0.0 2.3 1 1 1 2 2 2 0 Fructosamine kinase EcKinase PF02958.15 CCF32033.1 - 0.16 11.0 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase AzlC PF03591.9 CCF32036.1 - 4.4 7.2 16.2 0.028 14.3 2.2 3.2 3 1 0 3 3 3 0 AzlC protein SIR2 PF02146.12 CCF32037.1 - 5.1e-22 78.4 0.0 6.7e-22 78.0 0.0 1.1 1 0 0 1 1 1 1 Sir2 family Peptidase_S8 PF00082.17 CCF32041.1 - 1.7e-43 148.8 1.6 2.4e-43 148.2 1.1 1.2 1 0 0 1 1 1 1 Subtilase family DUF1034 PF06280.7 CCF32041.1 - 1.8e-08 34.7 0.7 2.8e-07 30.9 0.0 2.7 3 0 0 3 3 3 1 Fn3-like domain (DUF1034) PA PF02225.17 CCF32041.1 - 0.019 14.6 0.0 0.072 12.7 0.0 2.0 1 0 0 1 1 1 0 PA domain Opi1 PF08618.5 CCF32042.1 - 2.5e-83 280.4 10.0 5.5e-51 173.8 0.5 4.8 3 2 2 5 5 5 3 Transcription factor Opi1 AA_permease_N PF08403.5 CCF32042.1 - 0.015 14.6 0.8 0.047 12.9 0.6 1.8 1 0 0 1 1 1 0 Amino acid permease N-terminal Ribosomal_S7 PF00177.16 CCF32043.1 - 6.4e-41 139.3 1.2 7.9e-41 139.0 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Acetyltransf_1 PF00583.19 CCF32044.1 - 1.1e-05 25.3 1.4 0.00018 21.4 1.0 2.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF32044.1 - 0.0026 17.8 0.0 0.0088 16.1 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_5 PF13444.1 CCF32044.1 - 0.0048 17.4 0.0 1.2 9.7 0.0 2.9 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain HMA PF00403.21 CCF32045.1 - 1.2e-15 57.4 0.6 1.2e-15 57.4 0.4 1.6 2 0 0 2 2 2 1 Heavy-metal-associated domain DUF1280 PF06918.9 CCF32045.1 - 0.11 11.7 0.1 0.12 11.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1280) Tcf25 PF04910.9 CCF32046.1 - 8.2e-70 235.5 0.1 8.2e-70 235.5 0.0 1.6 2 0 0 2 2 2 1 Transcriptional repressor TCF25 NIF PF03031.13 CCF32047.1 - 4.2e-51 172.7 0.0 5.8e-51 172.3 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase IF-2B PF01008.12 CCF32048.1 - 1.6e-39 135.5 0.0 6.1e-39 133.7 0.0 1.8 1 1 0 1 1 1 1 Initiation factor 2 subunit family DUF605 PF04652.11 CCF32049.1 - 9.2 5.5 18.9 11 5.3 13.1 1.0 1 0 0 1 1 1 0 Vta1 like EST1_DNA_bind PF10373.4 CCF32050.1 - 2.3e-16 59.8 0.0 4.4e-16 58.9 0.0 1.5 1 1 0 1 1 1 1 Est1 DNA/RNA binding domain ApoL PF05461.6 CCF32051.1 - 0.021 14.1 0.5 0.025 13.8 0.4 1.1 1 0 0 1 1 1 0 Apolipoprotein L Ribosomal_L18e PF00828.14 CCF32051.1 - 0.068 13.5 2.4 0.1 12.9 1.7 1.2 1 0 0 1 1 1 0 Ribosomal protein L18e/L15 PX PF00787.19 CCF32052.1 - 3.1e-17 62.3 0.1 6e-17 61.4 0.0 1.5 1 0 0 1 1 1 1 PX domain Drf_GBD PF06371.8 CCF32055.1 - 4.6e-66 221.7 0.5 1.3e-65 220.3 0.0 1.9 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.11 CCF32055.1 - 3e-53 180.1 3.3 1.3e-52 178.0 1.9 2.2 1 1 1 2 2 2 1 Diaphanous FH3 Domain zf-RING_2 PF13639.1 CCF32058.1 - 1.6e-08 34.2 5.8 1.6e-08 34.2 4.0 2.6 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.2 CCF32058.1 - 8.7e-07 28.9 5.6 1.7e-06 27.9 2.6 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 CCF32058.1 - 4.3e-06 26.2 0.5 4.3e-06 26.2 0.4 2.5 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CCF32058.1 - 7.7e-06 25.8 1.4 7.7e-06 25.8 1.0 3.2 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF32058.1 - 2.8e-05 23.6 1.5 2.8e-05 23.6 1.0 2.5 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF32058.1 - 0.00046 19.8 7.0 0.0011 18.6 1.9 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-Apc11 PF12861.2 CCF32058.1 - 0.002 17.9 4.5 0.002 17.9 3.1 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 CCF32058.1 - 0.029 14.1 0.2 0.029 14.1 0.1 3.4 2 1 1 3 3 3 0 RING-type zinc-finger NDUF_B12 PF08122.7 CCF32058.1 - 0.068 12.9 3.4 1.6 8.5 1.1 2.6 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B12 subunit family zf-C3HC4_4 PF15227.1 CCF32058.1 - 0.076 12.8 0.2 0.076 12.8 0.2 3.2 4 0 0 4 4 4 0 zinc finger of C3HC4-type, RING Zn_ribbon_recom PF13408.1 CCF32058.1 - 4.7 7.5 8.5 14 5.9 1.6 3.0 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain RRM_1 PF00076.17 CCF32059.1 - 1.8e-11 43.5 0.1 8.2e-10 38.1 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF32059.1 - 2.5e-08 33.7 0.1 4.1e-07 29.8 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF32059.1 - 0.1 12.4 0.1 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAD_binding_1 PF00667.15 CCF32060.1 - 5.4e-59 199.2 0.0 8.4e-59 198.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 CCF32060.1 - 9.2e-32 110.0 0.8 2.1e-31 108.8 0.5 1.7 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 CCF32060.1 - 2.3e-22 79.6 0.0 2.3e-21 76.4 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.2 CCF32060.1 - 0.011 15.7 0.1 0.046 13.7 0.0 2.1 2 0 0 2 2 2 0 Flavodoxin domain Pkinase PF00069.20 CCF32061.1 - 8.4e-64 215.2 0.0 1.7e-63 214.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF32061.1 - 4.9e-36 124.1 0.0 1.2e-30 106.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 CCF32061.1 - 9.6e-06 24.7 0.1 0.0094 14.9 0.0 2.2 1 1 1 2 2 2 2 Kinase-like APH PF01636.18 CCF32061.1 - 0.00097 18.9 0.0 0.002 17.8 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 CCF32061.1 - 0.0084 15.4 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 CCF32061.1 - 0.021 13.8 0.0 0.039 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sel1 PF08238.7 CCF32062.1 - 2.5e-39 132.8 34.5 4.3e-07 30.3 0.0 8.3 8 0 0 8 8 8 7 Sel1 repeat TPR_20 PF14561.1 CCF32062.1 - 0.062 13.4 0.2 0.18 11.9 0.2 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat PfkB PF00294.19 CCF32063.1 - 1.1e-52 179.0 1.0 1.3e-52 178.8 0.7 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase DDDD PF10161.4 CCF32065.1 - 0.089 12.4 0.9 2 8.1 0.0 2.3 1 1 1 2 2 2 0 Putative mitochondrial precursor protein UQ_con PF00179.21 CCF32066.1 - 9.4e-10 38.0 0.0 1.4e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme BRE PF06113.7 CCF32066.1 - 0.0094 15.0 0.1 0.014 14.5 0.1 1.1 1 0 0 1 1 1 1 Brain and reproductive organ-expressed protein (BRE) RWD PF05773.17 CCF32066.1 - 0.14 12.1 0.1 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 RWD domain DUF1014 PF06244.7 CCF32067.1 - 1.4e-22 80.1 6.6 1.4e-22 80.1 4.5 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF1014) DUF4552 PF15089.1 CCF32067.1 - 0.046 12.6 0.1 0.062 12.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4552) Fzo_mitofusin PF04799.8 CCF32067.1 - 0.048 13.0 0.2 0.081 12.3 0.2 1.2 1 0 0 1 1 1 0 fzo-like conserved region DUF2894 PF11445.3 CCF32067.1 - 3.2 7.9 13.7 0.62 10.3 2.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2894) DUF1835 PF08874.5 CCF32067.1 - 5.6 6.9 6.9 8.4 6.3 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF1835) Hamartin PF04388.7 CCF32067.1 - 5.9 5.4 8.7 3.5 6.1 5.0 1.3 1 1 0 1 1 1 0 Hamartin protein A_amylase_inhib PF01356.14 CCF32068.1 - 0.017 14.9 0.2 0.72 9.6 0.0 2.5 2 1 0 2 2 2 0 Alpha amylase inhibitor adh_short PF00106.20 CCF32069.1 - 2e-14 53.8 0.1 3.4e-14 53.0 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF32069.1 - 1.5e-05 24.7 0.1 2.3e-05 24.1 0.1 1.5 1 1 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF32069.1 - 0.011 15.5 0.0 0.015 15.1 0.0 1.4 1 1 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Pkinase PF00069.20 CCF32070.1 - 8.5e-32 110.3 0.0 1.4e-31 109.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF32070.1 - 0.00032 19.8 0.0 0.042 12.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase adh_short PF00106.20 CCF32071.1 - 2.6e-14 53.4 0.6 6.8e-14 52.1 0.4 1.6 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 CCF32071.1 - 1.7e-05 24.5 0.2 3.2e-05 23.6 0.1 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF32071.1 - 0.00013 21.4 0.0 0.00021 20.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 CCF32071.1 - 0.032 13.9 0.0 0.046 13.4 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase AdoHcyase_NAD PF00670.16 CCF32071.1 - 0.14 12.0 0.4 0.22 11.3 0.2 1.2 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_kinase PF01513.16 CCF32073.1 - 3.5e-68 229.4 0.0 5.5e-68 228.8 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DUF3402 PF11882.3 CCF32074.1 - 6.8e-157 522.7 0.0 9.1e-157 522.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) N1221 PF07923.8 CCF32074.1 - 1.7e-75 253.6 0.0 2.9e-75 252.8 0.0 1.4 1 0 0 1 1 1 1 N1221-like protein MARVEL PF01284.18 CCF32075.1 - 0.00056 19.7 18.0 0.0047 16.7 12.7 2.0 1 1 0 1 1 1 1 Membrane-associating domain DUF3422 PF11902.3 CCF32075.1 - 0.45 9.3 1.2 3 6.6 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3422) GRP PF07172.6 CCF32075.1 - 2.7 8.5 9.2 76 3.8 0.0 2.6 2 1 1 3 3 3 0 Glycine rich protein family DUF4233 PF14017.1 CCF32075.1 - 8.8 6.3 10.1 6 6.8 4.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4233) WSC PF01822.14 CCF32076.1 - 4.9e-75 247.4 72.6 3.3e-19 68.6 7.8 5.2 4 0 0 4 4 4 4 WSC domain peroxidase PF00141.18 CCF32076.1 - 3.6e-20 72.4 0.1 7.6e-20 71.3 0.1 1.4 1 0 0 1 1 1 1 Peroxidase DUF605 PF04652.11 CCF32076.1 - 5.5 6.2 21.6 10 5.4 15.0 1.3 1 0 0 1 1 1 0 Vta1 like Sec7 PF01369.15 CCF32077.1 - 3.3e-44 150.8 0.0 6.5e-44 149.8 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.1 CCF32077.1 - 2.8e-16 59.7 0.0 6.6e-16 58.5 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PRKCSH PF07915.8 CCF32078.1 - 2.3e-19 69.9 0.2 2.3e-19 69.9 0.2 2.2 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.1 CCF32078.1 - 0.025 14.0 0.0 2 7.8 0.0 2.3 2 0 0 2 2 2 0 Glucosidase II beta subunit-like protein ArfGap PF01412.13 CCF32080.1 - 1.7e-32 111.6 0.0 1.7e-32 111.6 0.0 2.3 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf PH PF00169.24 CCF32080.1 - 5.6e-13 48.9 1.4 1e-12 48.1 0.2 2.0 2 0 0 2 2 2 1 PH domain EMP24_GP25L PF01105.19 CCF32080.1 - 0.11 12.1 2.3 0.26 10.9 1.6 1.6 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD PH_9 PF15410.1 CCF32080.1 - 0.2 11.8 5.1 0.5 10.5 0.8 3.2 2 1 0 2 2 2 0 Pleckstrin homology domain Pkinase PF00069.20 CCF32081.1 - 1e-77 260.8 0.0 1.5e-77 260.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF32081.1 - 5.6e-38 130.4 0.0 7.7e-38 130.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 CCF32081.1 - 3.2e-18 65.6 0.2 7.2e-18 64.4 0.1 1.7 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.1 CCF32081.1 - 5.5e-10 38.6 0.0 3.7e-08 32.6 0.0 2.6 3 0 0 3 3 3 1 Kinase-like Kdo PF06293.9 CCF32081.1 - 4.1e-05 22.7 0.1 0.00029 19.9 0.0 2.2 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.6 CCF32081.1 - 0.013 14.3 0.1 0.024 13.4 0.1 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase YrbL-PhoP_reg PF10707.4 CCF32081.1 - 0.055 12.8 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DnaJ PF00226.26 CCF32082.1 - 3.5e-21 74.7 2.0 8.1e-21 73.5 1.4 1.7 1 0 0 1 1 1 1 DnaJ domain MFS_1 PF07690.11 CCF32084.1 - 9.4e-07 27.8 8.5 9.8e-07 27.7 5.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF32084.1 - 0.072 11.6 2.6 0.079 11.5 1.8 1.0 1 0 0 1 1 1 0 Sugar (and other) transporter DUF4212 PF13937.1 CCF32084.1 - 0.17 11.9 1.4 0.19 11.7 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4212) DUF3142 PF11340.3 CCF32085.1 - 0.027 14.1 0.0 0.045 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3142) Ferritin_2 PF13668.1 CCF32086.1 - 2.5e-05 24.2 0.0 4.1e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Ferritin-like domain DUF1658 PF07871.6 CCF32087.1 - 0.027 14.0 0.0 0.049 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1658) GyrI-like PF06445.10 CCF32088.1 - 0.042 13.8 0.0 0.046 13.7 0.0 1.1 1 0 0 1 1 1 0 GyrI-like small molecule binding domain MaoC_dehydratas PF01575.14 CCF32092.1 - 8.3e-20 70.3 0.0 1.4e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.1 CCF32092.1 - 7e-08 32.3 0.0 8e-07 28.9 0.0 2.1 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase ERp29_N PF07912.8 CCF32092.1 - 0.01 15.7 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 ERp29, N-terminal domain CAP_GLY PF01302.20 CCF32093.1 - 1.5e-20 72.6 0.0 2.5e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain Gly_transf_sug PF04488.10 CCF32095.1 - 4.5e-12 46.2 0.1 7.9e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.7 CCF32095.1 - 0.0021 17.2 0.1 0.0038 16.4 0.0 1.4 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein TcdA_TcdB PF12919.2 CCF32095.1 - 0.013 14.0 0.8 0.053 11.9 0.1 2.1 3 0 0 3 3 3 0 TcdA/TcdB catalytic glycosyltransferase domain Transp_cyt_pur PF02133.10 CCF32096.1 - 4.4e-57 193.5 12.0 5.5e-57 193.2 8.3 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin NADH_dehy_S2_C PF06444.6 CCF32096.1 - 0.014 15.6 2.0 0.028 14.7 1.4 1.5 1 0 0 1 1 1 0 NADH dehydrogenase subunit 2 C-terminus ketoacyl-synt PF00109.21 CCF32097.1 - 6.2e-45 153.6 0.0 8.1e-45 153.2 0.0 1.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain DUF963 PF06131.6 CCF32097.1 - 3 7.2 9.5 0.047 12.9 1.6 1.9 2 0 0 2 2 2 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) MFS_1 PF07690.11 CCF32098.1 - 1e-25 90.2 53.7 4.9e-24 84.7 35.1 3.6 2 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF32098.1 - 1.4e-09 36.7 8.1 2.2e-09 36.0 5.6 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) TauD PF02668.11 CCF32099.1 - 8.1e-38 130.5 1.1 9.9e-38 130.2 0.8 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family 2OG-FeII_Oxy_3 PF13640.1 CCF32099.1 - 0.0056 17.1 0.1 1.7 9.1 0.1 2.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily FSH1 PF03959.8 CCF32100.1 - 1.3e-30 106.4 0.0 1.5e-30 106.2 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.2 CCF32100.1 - 1.2e-07 31.8 0.0 0.0014 18.5 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 CCF32100.1 - 2.7e-06 26.9 0.0 8.2e-06 25.4 0.0 1.8 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 CCF32100.1 - 0.00033 20.4 0.0 0.00061 19.5 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family UDPGT PF00201.13 CCF32101.1 - 0.019 13.5 0.0 0.053 12.0 0.0 1.7 2 0 0 2 2 2 0 UDP-glucoronosyl and UDP-glucosyl transferase AA_permease_N PF08403.5 CCF32101.1 - 0.04 13.2 0.3 0.18 11.1 0.0 2.0 2 0 0 2 2 2 0 Amino acid permease N-terminal Glyco_tran_WecB PF03808.8 CCF32101.1 - 0.12 11.7 0.0 1 8.7 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family Sugar_tr PF00083.19 CCF32102.1 - 3.5e-113 378.5 27.1 4.1e-113 378.3 18.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF32102.1 - 4.4e-25 88.1 26.3 4.3e-23 81.5 15.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1201 PF06716.6 CCF32102.1 - 6.9 6.5 10.9 0.57 10.0 3.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) CN_hydrolase PF00795.17 CCF32103.1 - 1e-37 129.3 0.0 1.3e-37 128.9 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase CIA30 PF08547.7 CCF32104.1 - 6.7e-35 120.2 0.0 8.1e-35 119.9 0.0 1.0 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) DUF3328 PF11807.3 CCF32105.1 - 2.2e-27 96.1 5.9 2.7e-27 95.8 4.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) MFS_1 PF07690.11 CCF32106.1 - 6.5e-14 51.4 10.5 2.4e-08 33.0 6.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF32106.1 - 5.9e-06 24.7 7.2 7.2e-06 24.4 5.0 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3154 PF11351.3 CCF32106.1 - 0.067 12.9 0.2 0.28 10.9 0.0 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3154) Ribonuc_P_40 PF08584.6 CCF32107.1 - 2.1e-65 220.5 0.0 2.9e-65 220.0 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit Ank_5 PF13857.1 CCF32108.1 - 5e-11 42.4 0.1 3.1e-09 36.7 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 CCF32108.1 - 1.4e-08 35.0 0.0 2.2e-05 24.8 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 CCF32108.1 - 3.1e-06 26.7 0.3 0.0022 17.7 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 CCF32108.1 - 9.7e-06 25.8 1.6 0.00095 19.4 0.1 2.4 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 CCF32108.1 - 9.1e-05 22.3 0.4 0.0054 16.8 0.1 2.7 2 0 0 2 2 2 1 Ankyrin repeat RNA_lig_T4_1 PF09511.5 CCF32109.1 - 1.6e-79 266.5 0.0 4e-79 265.1 0.0 1.7 2 0 0 2 2 2 1 RNA ligase tRNA_lig_CPD PF08302.6 CCF32109.1 - 2.8e-76 256.1 0.0 4e-76 255.6 0.0 1.3 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain tRNA_lig_kinase PF08303.6 CCF32109.1 - 5.8e-53 179.2 0.0 1.3e-52 178.0 0.0 1.6 1 0 0 1 1 1 1 tRNA ligase kinase domain AAA_17 PF13207.1 CCF32109.1 - 0.012 16.4 0.0 0.068 13.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain Ish1 PF10281.4 CCF32110.1 - 1e-74 246.0 26.6 1.5e-12 47.3 0.1 8.5 8 0 0 8 8 8 8 Putative stress-responsive nuclear envelope protein SAP PF02037.22 CCF32110.1 - 8.5e-10 37.8 0.0 2.1 7.9 0.0 7.6 8 0 0 8 8 8 3 SAP domain HeH PF12949.2 CCF32110.1 - 1.2e-05 24.7 0.0 6.2 6.4 0.0 6.1 7 1 0 7 7 7 1 HeH/LEM domain Slx4 PF09494.5 CCF32110.1 - 5.4e-05 22.8 2.0 19 5.0 0.0 6.0 7 0 0 7 7 7 1 Slx4 endonuclease Peptidase_U57 PF05582.7 CCF32110.1 - 0.013 14.5 0.0 0.03 13.2 0.0 1.6 1 0 0 1 1 1 0 YabG peptidase U57 SAM_2 PF07647.12 CCF32110.1 - 0.038 13.8 1.2 1.7 8.5 0.1 3.7 4 0 0 4 4 4 0 SAM domain (Sterile alpha motif) Thioredoxin_6 PF13848.1 CCF32110.1 - 0.047 13.4 0.0 17 5.1 0.0 3.3 2 1 1 3 3 3 0 Thioredoxin-like domain Hydrophobin_2 PF06766.6 CCF32111.1 - 3.6e-26 90.6 8.8 4.5e-26 90.3 6.1 1.1 1 0 0 1 1 1 1 Fungal hydrophobin AAA PF00004.24 CCF32112.1 - 8.9e-40 135.9 0.0 1.8e-39 134.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF32112.1 - 0.00017 21.6 0.6 0.012 15.5 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.9 CCF32112.1 - 0.0002 21.1 1.6 0.00078 19.1 0.0 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 CCF32112.1 - 0.00028 20.0 0.0 0.00064 18.8 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 CCF32112.1 - 0.00053 20.1 0.6 0.019 15.1 0.0 2.8 2 1 1 3 3 2 1 AAA domain AAA_2 PF07724.9 CCF32112.1 - 0.0014 18.5 0.3 0.0089 15.9 0.0 2.3 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) PhoH PF02562.11 CCF32112.1 - 0.0044 16.2 0.3 0.045 12.9 0.1 2.3 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.16 CCF32112.1 - 0.0069 15.5 0.0 0.017 14.3 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.8 CCF32112.1 - 0.008 15.1 0.0 0.017 14.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_33 PF13671.1 CCF32112.1 - 0.01 15.7 0.0 0.025 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 CCF32112.1 - 0.017 14.8 0.4 0.044 13.5 0.3 1.6 1 0 0 1 1 1 0 Part of AAA domain IstB_IS21 PF01695.12 CCF32112.1 - 0.022 14.1 0.1 0.047 13.1 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.1 CCF32112.1 - 0.032 13.6 1.3 0.32 10.3 0.2 2.4 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.1 CCF32112.1 - 0.047 13.2 0.1 0.14 11.7 0.1 1.8 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 CCF32112.1 - 0.087 13.6 0.1 0.087 13.6 0.1 2.8 2 2 0 2 2 2 0 AAA domain AAA_11 PF13086.1 CCF32112.1 - 0.092 12.3 0.1 0.61 9.6 0.0 2.3 2 1 0 2 2 2 0 AAA domain hDGE_amylase PF14701.1 CCF32113.1 - 1e-176 587.9 0.0 1.3e-176 587.6 0.0 1.1 1 0 0 1 1 1 1 glucanotransferase domain of human glycogen debranching enzyme GDE_C PF06202.9 CCF32113.1 - 1e-110 369.9 0.0 2.1e-110 368.9 0.0 1.5 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.1 CCF32113.1 - 1.3e-89 299.8 0.0 6.3e-89 297.5 0.0 2.0 2 0 0 2 2 2 1 central domain of human glycogen debranching enzyme hGDE_N PF14699.1 CCF32113.1 - 4.1e-27 93.8 0.0 9.8e-27 92.6 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.19 CCF32113.1 - 0.00012 21.6 0.0 0.36 10.1 0.0 2.3 2 0 0 2 2 2 2 Alpha amylase, catalytic domain ATG27 PF09451.5 CCF32114.1 - 0.05 12.8 0.2 0.061 12.5 0.1 1.1 1 0 0 1 1 1 0 Autophagy-related protein 27 Trep_Strep PF09605.5 CCF32114.1 - 0.083 12.5 0.0 0.098 12.3 0.0 1.2 1 0 0 1 1 1 0 Hypothetical bacterial integral membrane protein (Trep_Strep) UPF0370 PF13980.1 CCF32114.1 - 0.39 10.5 2.9 0.61 9.9 2.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) Cu-oxidase_2 PF07731.9 CCF32115.1 - 6.5e-25 87.2 10.4 1.8e-23 82.5 1.9 3.1 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.10 CCF32115.1 - 4.5e-20 71.5 0.1 4.5e-20 71.5 0.0 2.6 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.17 CCF32115.1 - 2.8e-06 27.3 0.1 6.2e-05 22.9 0.0 3.0 4 0 0 4 4 4 1 Multicopper oxidase F-box-like PF12937.2 CCF32117.1 - 0.0035 17.0 0.3 0.013 15.2 0.2 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF32117.1 - 0.012 15.2 0.2 0.068 12.8 0.1 2.4 1 0 0 1 1 1 0 F-box domain DUF4246 PF14033.1 CCF32118.1 - 0.7 8.4 15.5 1.6 7.2 3.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4246) HAP1_N PF04849.8 CCF32119.1 - 0.0091 14.9 2.0 0.016 14.1 1.4 1.3 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Prefoldin_2 PF01920.15 CCF32119.1 - 0.021 14.5 1.5 0.021 14.5 1.0 2.0 1 1 1 2 2 2 0 Prefoldin subunit DUF972 PF06156.8 CCF32119.1 - 1.4 9.3 6.0 1 9.7 1.4 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF972) BSP_II PF05432.6 CCF32121.1 - 0.095 11.9 2.1 0.13 11.5 1.4 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Spt5_N PF11942.3 CCF32121.1 - 0.13 12.8 5.5 0.22 12.1 3.8 1.3 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Cullin PF00888.17 CCF32122.1 - 9.6e-128 427.2 10.1 1.5e-127 426.6 7.0 1.3 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 CCF32122.1 - 4.6e-27 93.6 1.7 1.8e-26 91.7 1.2 2.1 1 0 0 1 1 1 1 Cullin protein neddylation domain Rrf2 PF02082.15 CCF32122.1 - 0.087 12.9 0.1 0.57 10.3 0.0 2.4 3 0 0 3 3 3 0 Transcriptional regulator DPPIV_N PF00930.16 CCF32123.1 - 5.3e-105 350.8 0.3 8.1e-105 350.2 0.2 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.16 CCF32123.1 - 6.6e-53 179.0 2.2 1.3e-52 178.1 1.5 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CCF32123.1 - 1.8e-09 37.4 0.2 3.9e-09 36.4 0.1 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.13 CCF32123.1 - 3.7e-07 29.8 2.2 5.1e-06 26.1 0.4 2.4 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.2 CCF32123.1 - 2.3e-06 27.6 0.8 3.1e-05 23.9 0.5 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.7 CCF32123.1 - 0.088 11.2 0.1 2.7 6.4 0.0 2.2 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) YbjQ_1 PF01906.12 CCF32124.1 - 7.9e-26 90.5 0.0 9.4e-26 90.2 0.0 1.1 1 0 0 1 1 1 1 Putative heavy-metal-binding DUF3328 PF11807.3 CCF32125.1 - 9.2e-18 64.7 1.1 9.7e-18 64.6 0.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.3 CCF32126.1 - 0.0011 18.7 0.0 0.0014 18.3 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) NapE PF06796.6 CCF32126.1 - 0.044 13.0 1.1 0.078 12.3 0.7 1.3 1 0 0 1 1 1 0 Periplasmic nitrate reductase protein NapE Pex14_N PF04695.8 CCF32127.1 - 0.001 19.1 1.1 0.0016 18.5 0.8 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region FimP PF09766.4 CCF32127.1 - 0.0024 17.0 2.2 0.0032 16.5 1.5 1.2 1 0 0 1 1 1 1 Fms-interacting protein Cadherin_C PF01049.12 CCF32127.1 - 0.0034 17.4 2.5 0.0069 16.4 1.8 1.4 1 0 0 1 1 1 1 Cadherin cytoplasmic region Med15 PF09606.5 CCF32127.1 - 0.03 12.5 11.3 0.037 12.2 7.8 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Scs3p PF10261.4 CCF32127.1 - 0.034 13.1 0.0 0.051 12.5 0.0 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Coiled-coil_56 PF09813.4 CCF32127.1 - 0.034 14.1 1.3 0.063 13.2 0.9 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 DUF2407_C PF13373.1 CCF32127.1 - 0.053 13.4 0.0 0.089 12.7 0.0 1.3 1 0 0 1 1 1 0 DUF2407 C-terminal domain 7tm_1 PF00001.16 CCF32127.1 - 0.069 12.2 0.3 0.11 11.5 0.2 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF3525 PF12039.3 CCF32127.1 - 0.12 10.8 0.0 0.17 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3525) DUF2722 PF10846.3 CCF32127.1 - 0.44 9.5 8.0 0.64 8.9 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) FCP1_C PF09309.5 CCF32127.1 - 0.55 9.4 5.9 0.96 8.7 4.1 1.3 1 0 0 1 1 1 0 FCP1, C-terminal Phostensin_N PF13916.1 CCF32127.1 - 2.5 8.1 9.4 5.3 7.0 6.5 1.6 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal DUF4175 PF13779.1 CCF32127.1 - 5.3 4.6 15.5 7 4.2 10.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF3328 PF11807.3 CCF32128.1 - 1.7e-21 76.9 0.1 4.7e-21 75.4 0.1 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) 2OG-FeII_Oxy PF03171.15 CCF32129.1 - 0.0083 16.4 0.0 0.027 14.7 0.0 1.9 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Abhydrolase_6 PF12697.2 CCF32130.1 - 1.4e-07 31.6 0.0 1.5e-07 31.5 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF32130.1 - 0.11 12.0 0.0 0.11 12.0 0.0 1.0 1 0 0 1 1 1 0 alpha/beta hydrolase fold LEP503 PF15221.1 CCF32130.1 - 0.17 11.6 0.3 0.35 10.5 0.1 1.7 1 1 1 2 2 2 0 Lens epithelial cell protein LEP503 UTP15_C PF09384.5 CCF32131.1 - 5.6e-40 136.4 0.0 1.1e-39 135.5 0.0 1.4 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.27 CCF32131.1 - 1.1e-26 91.6 10.6 2.5e-10 39.8 0.2 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat BBS2_Mid PF14783.1 CCF32131.1 - 0.0082 15.9 0.0 0.55 10.0 0.0 3.3 1 1 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Pinin_SDK_memA PF04696.8 CCF32131.1 - 0.12 11.9 1.0 0.2 11.2 0.7 1.3 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region Gln-synt_C PF00120.19 CCF32132.1 - 4.4e-61 206.2 0.0 5.1e-61 206.0 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.14 CCF32132.1 - 1.1e-15 56.9 0.0 2.7e-15 55.7 0.0 1.7 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain DUF2781 PF10914.3 CCF32134.1 - 1e-30 106.5 11.0 1.2e-30 106.3 7.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) EBP PF05241.7 CCF32134.1 - 0.086 11.8 3.1 0.13 11.2 2.2 1.2 1 0 0 1 1 1 0 Emopamil binding protein DUF1049 PF06305.6 CCF32135.1 - 7.7 6.0 6.9 0.42 10.1 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) Hydrolase_4 PF12146.3 CCF32136.1 - 0.13 12.1 0.1 0.22 11.3 0.1 1.5 1 1 0 1 1 1 0 Putative lysophospholipase RRM_6 PF14259.1 CCF32139.1 - 0.12 12.3 0.0 0.35 10.8 0.0 1.7 1 1 1 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.20 CCF32140.1 - 2e-42 145.1 0.0 2e-38 132.0 0.0 3.0 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CCF32140.1 - 6.4e-15 54.9 0.0 1.1e-08 34.5 0.0 3.7 4 0 0 4 4 4 2 Protein tyrosine kinase APH PF01636.18 CCF32140.1 - 0.00027 20.7 0.1 0.1 12.3 0.0 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.1 CCF32140.1 - 0.0064 15.4 0.0 0.26 10.2 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 CCF32140.1 - 0.028 13.4 0.0 1.3 7.9 0.0 2.7 3 0 0 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family CDC45 PF02724.9 CCF32140.1 - 7.9 4.3 6.5 11 3.9 4.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_L18e PF00828.14 CCF32141.1 - 1.2e-34 119.5 0.1 1.6e-34 119.0 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 Helicase_C_2 PF13307.1 CCF32142.1 - 4.6e-59 199.1 0.2 1.6e-58 197.3 0.0 2.1 3 0 0 3 3 3 1 Helicase C-terminal domain DEAD_2 PF06733.10 CCF32142.1 - 3e-46 156.9 0.0 5.4e-46 156.1 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 GCV_T PF01571.16 CCF32143.1 - 1.9e-57 194.0 0.1 2.7e-57 193.5 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 CCF32143.1 - 1.7e-23 82.4 1.3 4.1e-23 81.2 0.6 1.9 2 0 0 2 2 2 1 Glycine cleavage T-protein C-terminal barrel domain Pkinase PF00069.20 CCF32144.1 - 1.5e-67 227.4 0.0 2.8e-67 226.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF32144.1 - 9.2e-37 126.5 0.0 1.7e-36 125.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF32144.1 - 7.9e-08 31.5 0.0 1.6e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CCF32144.1 - 0.025 14.3 0.0 0.094 12.4 0.0 2.0 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 CCF32144.1 - 0.058 12.2 0.0 0.1 11.3 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Peptidase_S66 PF02016.10 CCF32145.1 - 3e-52 177.3 0.0 4e-52 176.9 0.0 1.2 1 0 0 1 1 1 1 LD-carboxypeptidase Peptidase_S8 PF00082.17 CCF32146.1 - 9.6e-18 64.3 0.0 1.5e-17 63.6 0.0 1.2 1 0 0 1 1 1 1 Subtilase family Glyco_transf_25 PF01755.12 CCF32147.1 - 2.7e-15 56.5 0.0 3e-10 40.0 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase family 25 (LPS biosynthesis protein) DLH PF01738.13 CCF32148.1 - 8.9e-09 34.9 0.0 1.1e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Chlorophyllase2 PF12740.2 CCF32148.1 - 0.061 12.2 0.0 0.079 11.8 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Asp PF00026.18 CCF32149.1 - 8.8e-19 67.8 2.0 3.2e-13 49.6 0.8 2.7 1 1 1 2 2 2 2 Eukaryotic aspartyl protease TAXi_C PF14541.1 CCF32149.1 - 0.029 13.9 0.0 0.055 13.0 0.0 1.4 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal Glyco_hydro_75 PF07335.6 CCF32150.1 - 2e-44 151.2 0.1 2.5e-44 150.9 0.1 1.1 1 0 0 1 1 1 1 Fungal chitosanase of glycosyl hydrolase group 75 Chitin_bind_3 PF03067.10 CCF32152.1 - 6.4e-05 23.2 0.0 0.00011 22.4 0.0 1.5 1 0 0 1 1 1 1 Chitin binding domain Glyco_hydro_61 PF03443.9 CCF32152.1 - 0.00012 21.9 0.0 0.00021 21.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 RPA_interact_N PF14766.1 CCF32153.1 - 0.32 10.4 2.6 0.43 10.0 0.5 2.1 2 0 0 2 2 2 0 Replication protein A interacting N-terminal DAO PF01266.19 CCF32155.1 - 8.9e-38 130.1 0.0 1.1e-37 129.7 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF32155.1 - 9.3e-07 28.7 0.0 2.9e-06 27.1 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF32155.1 - 0.00046 20.3 0.0 0.0013 18.7 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CCF32155.1 - 0.0028 17.5 0.0 1.9 8.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.16 CCF32155.1 - 0.017 14.9 0.0 0.038 13.8 0.0 1.5 1 0 0 1 1 1 0 ThiF family Thi4 PF01946.12 CCF32155.1 - 0.033 13.2 0.0 0.059 12.4 0.0 1.3 1 0 0 1 1 1 0 Thi4 family FAD_binding_3 PF01494.14 CCF32155.1 - 0.036 13.1 0.0 0.063 12.3 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.1 CCF32155.1 - 0.042 13.6 0.1 0.21 11.3 0.0 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.7 CCF32155.1 - 0.13 11.1 0.1 3.3 6.5 0.0 2.6 2 1 1 3 3 3 0 Lycopene cyclase protein Fungal_trans PF04082.13 CCF32156.1 - 5.9e-18 64.6 0.3 1.1e-17 63.8 0.2 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Aa_trans PF01490.13 CCF32157.1 - 2.1e-26 92.3 12.2 2.4e-26 92.1 8.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 CCF32157.1 - 0.0042 15.9 15.1 0.005 15.7 10.2 1.4 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family Pirin PF02678.11 CCF32158.1 - 6.5e-25 87.0 1.1 2e-24 85.5 0.8 1.8 1 1 0 1 1 1 1 Pirin Cupin_2 PF07883.6 CCF32158.1 - 0.00054 19.4 2.6 0.049 13.1 0.4 3.0 2 1 0 2 2 2 2 Cupin domain AraC_binding_2 PF14525.1 CCF32158.1 - 0.044 13.3 0.0 0.085 12.4 0.0 1.4 1 0 0 1 1 1 0 AraC-binding-like domain MelC1 PF06236.6 CCF32158.1 - 0.099 12.6 0.1 0.38 10.7 0.0 1.9 2 0 0 2 2 2 0 Tyrosinase co-factor MelC1 Yae1_N PF09811.4 CCF32159.1 - 5.5e-12 45.0 1.6 1.2e-11 43.9 1.1 1.6 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Bacteriocin_IIc PF10439.4 CCF32159.1 - 1 9.5 4.1 0.38 10.9 1.2 1.5 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide ABC2_membrane PF01061.19 CCF32164.1 - 1.4e-79 266.1 48.9 3.2e-43 147.3 16.9 3.3 4 0 0 4 4 3 2 ABC-2 type transporter ABC_tran PF00005.22 CCF32164.1 - 1.2e-33 116.2 0.0 2.9e-16 60.0 0.0 2.4 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.7 CCF32164.1 - 4.1e-32 109.9 11.1 2.1e-31 107.6 0.0 3.5 4 0 0 4 4 3 2 CDR ABC transporter ABC_trans_N PF14510.1 CCF32164.1 - 2.2e-18 66.0 0.0 7.1e-18 64.4 0.0 1.9 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_25 PF13481.1 CCF32164.1 - 6.2e-07 29.0 0.0 0.00029 20.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain ABC2_membrane_3 PF12698.2 CCF32164.1 - 1.8e-06 27.2 41.4 0.0036 16.3 12.2 3.1 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_29 PF13555.1 CCF32164.1 - 7.8e-05 22.1 0.9 0.026 14.0 0.1 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_33 PF13671.1 CCF32164.1 - 0.00024 21.0 1.1 0.01 15.6 0.0 3.1 3 0 0 3 3 3 1 AAA domain DUF258 PF03193.11 CCF32164.1 - 0.00027 20.1 0.0 0.0076 15.4 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 CCF32164.1 - 0.00031 20.7 0.3 0.075 13.0 0.1 2.5 2 0 0 2 2 2 1 AAA ATPase domain cobW PF02492.14 CCF32164.1 - 0.0016 17.8 3.3 0.0048 16.3 0.1 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SMC_N PF02463.14 CCF32164.1 - 0.0017 17.6 0.0 0.1 11.7 0.0 2.9 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 CCF32164.1 - 0.0025 17.9 0.2 1.3 9.1 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_21 PF13304.1 CCF32164.1 - 0.0058 16.6 0.3 1.8 8.4 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CCF32164.1 - 0.0091 15.7 2.7 1.9 8.2 0.1 2.7 2 0 0 2 2 2 1 Part of AAA domain NACHT PF05729.7 CCF32164.1 - 0.016 14.8 0.7 2.7 7.6 0.1 2.8 2 0 0 2 2 2 0 NACHT domain PDR_assoc PF08370.6 CCF32164.1 - 0.017 14.6 6.3 4.6 6.8 0.2 3.7 3 0 0 3 3 3 0 Plant PDR ABC transporter associated AAA_18 PF13238.1 CCF32164.1 - 0.021 15.1 0.1 0.33 11.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 CCF32164.1 - 0.025 15.4 0.0 0.59 10.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 CCF32164.1 - 0.072 13.2 0.1 8.5 6.5 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) T2SE PF00437.15 CCF32164.1 - 0.073 11.9 0.2 5.5 5.7 0.1 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein Miro PF08477.8 CCF32164.1 - 0.074 13.5 0.0 14 6.1 0.0 2.7 3 0 0 3 3 2 0 Miro-like protein AAA_23 PF13476.1 CCF32164.1 - 0.095 13.0 0.1 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 CCF32164.1 - 0.097 12.6 1.2 0.17 11.8 0.0 2.1 2 0 0 2 2 1 0 AAA domain UPF0079 PF02367.12 CCF32164.1 - 0.1 12.2 1.8 0.29 10.7 0.2 2.3 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 MMR_HSR1 PF01926.18 CCF32164.1 - 0.1 12.5 0.0 12 5.8 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_30 PF13604.1 CCF32164.1 - 0.2 11.2 0.5 2.7 7.5 0.1 2.3 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 CCF32164.1 - 0.22 11.1 0.0 24 4.5 0.0 2.2 2 0 0 2 2 2 0 Archaeal ATPase AAA_10 PF12846.2 CCF32164.1 - 0.51 9.7 1.0 17 4.7 0.0 2.6 2 0 0 2 2 2 0 AAA-like domain PduV-EutP PF10662.4 CCF32164.1 - 0.68 9.4 1.2 2.1 7.8 0.1 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF87 PF01935.12 CCF32164.1 - 3.1 7.5 3.2 1.9 8.2 0.5 1.8 2 0 0 2 2 1 0 Domain of unknown function DUF87 Bac_luciferase PF00296.15 CCF32165.1 - 3.5e-50 170.8 0.0 4.1e-50 170.6 0.0 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase TIP49 PF06068.8 CCF32166.1 - 2.3e-21 76.0 0.3 2.5e-21 75.8 0.2 1.0 1 0 0 1 1 1 1 TIP49 C-terminus HALZ PF02183.13 CCF32167.1 - 3.6e-05 23.3 27.9 0.043 13.5 0.3 7.0 5 1 1 6 6 6 3 Homeobox associated leucine zipper AAA_13 PF13166.1 CCF32167.1 - 0.00062 18.3 5.4 0.00062 18.3 3.7 3.3 2 1 1 3 3 3 2 AAA domain DUF2968 PF11180.3 CCF32167.1 - 0.0011 18.3 5.8 0.0011 18.3 4.0 5.8 4 2 1 5 5 5 1 Protein of unknown function (DUF2968) BLOC1_2 PF10046.4 CCF32167.1 - 0.0011 19.0 29.7 0.021 14.9 0.1 7.3 5 2 2 7 7 7 3 Biogenesis of lysosome-related organelles complex-1 subunit 2 Myosin_tail_1 PF01576.14 CCF32167.1 - 0.0016 16.3 44.2 0.024 12.4 18.7 3.0 1 1 0 2 2 2 2 Myosin tail WEMBL PF05701.6 CCF32167.1 - 0.0025 16.3 10.1 0.0025 16.3 7.0 3.7 2 2 1 3 3 3 1 Weak chloroplast movement under blue light Pox_A_type_inc PF04508.7 CCF32167.1 - 0.0039 16.8 0.4 0.77 9.6 0.0 4.3 2 0 0 2 2 2 1 Viral A-type inclusion protein repeat Reo_sigmaC PF04582.7 CCF32167.1 - 0.0067 15.6 32.4 0.0094 15.1 6.5 5.7 1 1 5 6 6 6 1 Reovirus sigma C capsid protein DUF972 PF06156.8 CCF32167.1 - 0.028 14.7 34.0 0.8 10.0 3.1 5.9 4 2 1 5 5 5 0 Protein of unknown function (DUF972) DUF782 PF05614.6 CCF32167.1 - 0.13 12.4 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Circovirus protein of unknown function (DUF782) DUF869 PF05911.6 CCF32167.1 - 0.14 10.3 38.0 0.11 10.6 15.9 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF869) bZIP_1 PF00170.16 CCF32167.1 - 1.1 9.2 25.6 6.5 6.7 2.5 7.0 5 2 2 7 7 7 0 bZIP transcription factor CENP-F_leu_zip PF10473.4 CCF32167.1 - 1.3 8.9 50.1 0.28 11.0 1.7 5.8 2 2 3 6 6 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CALCOCO1 PF07888.6 CCF32167.1 - 1.9 6.6 51.0 0.049 11.9 5.7 3.8 3 2 0 4 4 4 0 Calcium binding and coiled-coil domain (CALCOCO1) like Hemerythrin PF01814.18 CCF32167.1 - 2.4 8.3 10.5 2 8.5 0.1 4.9 3 1 1 5 5 5 0 Hemerythrin HHE cation binding domain HisKA PF00512.20 CCF32167.1 - 2.4 8.1 8.0 4.1 7.4 0.0 4.3 4 1 1 5 5 5 0 His Kinase A (phospho-acceptor) domain HOOK PF05622.7 CCF32167.1 - 4.7 4.8 42.2 0.055 11.2 8.6 3.3 1 1 0 3 3 3 0 HOOK protein DUF2935 PF11155.3 CCF32167.1 - 5.3 7.1 15.9 7.5 6.6 0.1 4.5 4 1 0 4 4 4 0 Domain of unknown function (DUF2935) Tropomyosin_1 PF12718.2 CCF32167.1 - 6.5 6.5 55.4 0.029 14.2 1.9 6.8 5 3 0 5 5 5 0 Tropomyosin like Syntaxin-6_N PF09177.6 CCF32167.1 - 9.6 6.6 33.5 2.3 8.7 0.4 7.0 2 2 6 9 9 9 0 Syntaxin 6, N-terminal Barttin PF15462.1 CCF32168.1 - 0.041 13.5 1.3 0.048 13.3 0.9 1.1 1 0 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) Pellino PF04710.9 CCF32168.1 - 0.082 11.5 0.5 0.11 11.1 0.4 1.1 1 0 0 1 1 1 0 Pellino Glyco_hydro_18 PF00704.23 CCF32170.1 - 2.2e-49 168.7 0.1 3.5e-49 168.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.15 CCF32170.1 - 8e-12 44.8 0.1 0.0073 16.1 0.0 4.0 3 0 0 3 3 3 3 LysM domain Chitin_bind_1 PF00187.14 CCF32170.1 - 5.3e-05 23.1 4.6 5.3e-05 23.1 3.2 3.0 2 0 0 2 2 2 1 Chitin recognition protein DUF3142 PF11340.3 CCF32170.1 - 0.0011 18.7 0.0 0.0022 17.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3142) Peptidase_S8 PF00082.17 CCF32172.1 - 2.8e-24 85.7 0.9 4.1e-24 85.2 0.6 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 CCF32172.1 - 0.11 13.0 0.0 0.28 11.7 0.0 1.7 1 0 0 1 1 1 0 Peptidase inhibitor I9 zf-RING_2 PF13639.1 CCF32173.1 - 6.4e-09 35.5 5.9 6.4e-09 35.5 4.1 1.8 2 0 0 2 2 2 1 Ring finger domain FANCL_C PF11793.3 CCF32173.1 - 3.8e-05 23.5 11.2 0.00019 21.3 5.6 2.5 2 1 0 2 2 2 1 FANCL C-terminal domain zf-rbx1 PF12678.2 CCF32173.1 - 0.0002 21.4 3.1 0.0002 21.4 2.2 1.8 2 0 0 2 2 2 1 RING-H2 zinc finger zf-RING_5 PF14634.1 CCF32173.1 - 0.0016 18.0 6.7 0.0016 18.0 4.6 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-Apc11 PF12861.2 CCF32173.1 - 0.0027 17.5 2.2 0.0027 17.5 1.5 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.1 CCF32173.1 - 0.0097 15.9 7.0 0.0097 15.9 4.8 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF32173.1 - 0.012 15.2 3.4 0.012 15.2 2.4 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SWIM PF04434.12 CCF32173.1 - 0.052 13.0 0.7 0.11 11.9 0.5 1.6 1 0 0 1 1 1 0 SWIM zinc finger Pkinase PF00069.20 CCF32174.1 - 4.1e-11 42.5 0.0 6.3e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF32174.1 - 3.2e-07 29.6 0.0 5.3e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FAD_binding_4 PF01565.18 CCF32176.1 - 8.7e-21 73.8 3.0 2.3e-20 72.5 2.1 1.8 1 1 0 1 1 1 1 FAD binding domain BBE PF08031.7 CCF32176.1 - 0.00049 19.9 0.4 0.0034 17.2 0.1 2.3 2 0 0 2 2 2 1 Berberine and berberine like Sugar_tr PF00083.19 CCF32177.1 - 4.5e-80 269.4 20.7 5.3e-80 269.2 14.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF32177.1 - 1.2e-35 122.8 40.2 2.4e-28 98.8 19.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_2 PF04550.7 CCF32177.1 - 0.013 15.6 0.0 0.044 13.8 0.0 1.9 1 0 0 1 1 1 0 Phage holin family 2 FMO-like PF00743.14 CCF32178.1 - 2e-21 75.8 0.0 1e-09 37.1 0.0 3.1 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 CCF32178.1 - 8.2e-15 55.4 0.0 1.2e-13 51.6 0.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF32178.1 - 1.3e-08 34.8 1.1 0.0071 16.1 0.0 3.2 3 0 0 3 3 3 2 FAD-NAD(P)-binding K_oxygenase PF13434.1 CCF32178.1 - 2.4e-06 26.7 0.9 0.00029 19.8 0.0 3.2 3 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 CCF32178.1 - 0.0018 18.2 0.0 0.0046 16.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Sugar_tr PF00083.19 CCF32179.1 - 4e-81 272.8 27.5 4.5e-81 272.7 19.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF32179.1 - 6.1e-16 58.0 42.6 5.5e-12 45.0 14.8 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.8 CCF32179.1 - 0.014 13.5 0.1 0.014 13.5 0.1 2.2 2 1 0 2 2 2 0 Transmembrane secretion effector Glyco_hydro_43 PF04616.9 CCF32180.1 - 4.4e-24 85.0 0.0 5.4e-24 84.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 HeLo PF14479.1 CCF32181.1 - 1.8e-23 83.3 0.0 3.5e-23 82.4 0.0 1.4 1 1 0 1 1 1 1 Prion-inhibition and propagation Chromo PF00385.19 CCF32185.1 - 0.035 13.7 0.6 0.13 11.9 0.1 2.1 2 0 0 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain Methyltransf_23 PF13489.1 CCF32188.1 - 2.7e-21 75.9 0.0 4.6e-21 75.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF32188.1 - 1.2e-08 35.5 0.0 1.3e-07 32.1 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF32188.1 - 1.3e-07 31.2 0.0 1.8e-06 27.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF32188.1 - 8.2e-05 23.0 0.0 0.00018 21.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.13 CCF32188.1 - 0.0016 17.7 0.0 0.0029 16.9 0.0 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_12 PF08242.7 CCF32188.1 - 0.0078 16.6 0.0 0.062 13.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain DDE_1 PF03184.14 CCF32189.1 - 6.2e-53 179.1 0.0 9e-53 178.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 CCF32189.1 - 4.9e-08 32.8 0.1 5e-07 29.5 0.0 2.2 2 0 0 2 2 2 1 DDE superfamily endonuclease Pyr_redox_3 PF13738.1 CCF32190.1 - 6.3e-45 153.7 0.0 9.6e-45 153.1 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 CCF32190.1 - 0.0024 17.9 0.0 0.19 11.8 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase K_oxygenase PF13434.1 CCF32190.1 - 0.0078 15.1 0.0 0.016 14.1 0.0 1.5 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 CCF32190.1 - 0.0099 15.8 0.0 0.11 12.5 0.0 2.6 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain DDE_1 PF03184.14 CCF32191.1 - 2.2e-17 62.9 0.0 4e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 CCF32191.1 - 4e-12 45.7 0.2 1e-11 44.4 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF32191.1 - 6.6e-12 44.7 0.2 1.3e-11 43.8 0.2 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_28 PF13518.1 CCF32191.1 - 0.00034 20.5 0.9 0.0011 18.9 0.1 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 CCF32191.1 - 0.0014 18.2 0.1 0.0037 16.8 0.1 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.10 CCF32191.1 - 0.0056 16.5 0.6 0.011 15.6 0.4 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_8 PF02954.14 CCF32191.1 - 0.013 15.0 0.1 0.039 13.4 0.1 1.9 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_29 PF13551.1 CCF32191.1 - 0.014 15.5 0.9 0.033 14.3 0.4 1.9 1 1 0 1 1 1 0 Winged helix-turn helix HTH_Tnp_IS630 PF01710.11 CCF32191.1 - 0.014 15.0 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Transposase HTH_Tnp_1 PF01527.15 CCF32191.1 - 0.062 13.2 0.2 0.26 11.2 0.0 2.1 3 0 0 3 3 3 0 Transposase Methyltransf_11 PF08241.7 CCF32192.1 - 2.3e-11 44.0 0.0 4e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF32192.1 - 1.5e-10 41.5 0.0 7.4e-09 36.1 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF32192.1 - 1.8e-06 27.7 0.0 4.2e-06 26.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF32192.1 - 1.1e-05 25.0 0.0 1.9e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF32192.1 - 1.2e-05 25.7 0.0 2.5e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF32192.1 - 0.00012 21.2 0.0 0.00016 20.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 CCF32192.1 - 0.0021 18.0 0.2 0.1 12.6 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain DREV PF05219.7 CCF32192.1 - 0.0045 15.9 0.0 0.006 15.4 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase RrnaAD PF00398.15 CCF32192.1 - 0.009 15.0 0.0 0.013 14.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MTS PF05175.9 CCF32192.1 - 0.014 14.8 0.0 0.025 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Suf PF05843.9 CCF32194.1 - 9.2e-13 48.5 8.4 0.005 16.6 0.0 5.3 3 1 1 5 5 5 4 Suppressor of forked protein (Suf) TPR_12 PF13424.1 CCF32194.1 - 2.9e-12 46.3 0.7 0.27 11.1 0.0 6.9 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.1 CCF32194.1 - 9.8e-10 38.2 16.4 0.25 12.0 0.0 10.0 9 4 4 13 13 11 2 Tetratricopeptide repeat TPR_11 PF13414.1 CCF32194.1 - 6.1e-08 32.1 4.3 0.87 9.2 0.0 7.1 7 3 1 8 8 8 2 TPR repeat TPR_15 PF13429.1 CCF32194.1 - 1.1e-06 27.9 5.3 0.00012 21.2 0.9 3.6 3 1 1 4 4 4 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.7 CCF32194.1 - 2.4e-05 24.1 6.1 1.1 8.9 0.1 5.8 6 0 0 6 6 6 2 Mad3/BUB1 homology region 1 TPR_16 PF13432.1 CCF32194.1 - 4.3e-05 24.0 11.7 0.0071 16.9 0.0 6.3 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_8 PF13181.1 CCF32194.1 - 8e-05 22.1 0.9 1.6 8.6 0.0 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.12 CCF32194.1 - 8.2e-05 22.2 18.2 0.011 15.5 0.0 7.6 10 0 0 10 10 10 1 Tetratricopeptide repeat RPN7 PF10602.4 CCF32194.1 - 0.0007 19.0 1.0 0.0077 15.6 0.2 2.9 2 2 0 2 2 2 1 26S proteasome subunit RPN7 TPR_7 PF13176.1 CCF32194.1 - 0.0022 17.6 8.5 0.22 11.3 0.0 6.6 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_4 PF07721.9 CCF32194.1 - 0.01 16.1 0.2 0.75 10.3 0.0 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 CCF32194.1 - 0.015 14.8 0.1 0.75 9.5 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 CCF32194.1 - 0.027 14.8 5.3 34 5.1 0.0 6.5 5 1 1 6 6 6 0 Tetratricopeptide repeat PPR_3 PF13812.1 CCF32194.1 - 0.05 13.8 0.0 1.1 9.6 0.0 3.4 2 0 0 2 2 1 0 Pentatricopeptide repeat domain TPR_17 PF13431.1 CCF32194.1 - 0.27 11.5 6.8 25 5.3 0.0 5.9 8 0 0 8 8 7 0 Tetratricopeptide repeat DUF3129 PF11327.3 CCF32196.1 - 2.8e-60 203.2 10.9 3.5e-60 202.9 7.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3129) DDE_1 PF03184.14 CCF32197.1 - 8.4e-26 90.4 0.0 1e-25 90.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease IBR PF01485.16 CCF32198.1 - 5.6e-11 42.1 46.5 9e-07 28.6 4.0 4.0 4 0 0 4 4 4 3 IBR domain Reprolysin_2 PF13574.1 CCF32198.1 - 0.068 13.2 0.0 0.23 11.4 0.0 1.9 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like GHMP_kinases_N PF00288.21 CCF32199.1 - 1.8e-15 56.7 1.5 3.9e-15 55.6 1.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 CCF32199.1 - 1.6e-06 28.1 0.1 4.4e-06 26.8 0.1 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal Rib_5-P_isom_A PF06026.9 CCF32200.1 - 6.8e-37 126.4 0.0 1.9e-33 115.2 0.0 2.1 2 0 0 2 2 2 2 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.17 CCF32200.1 - 0.033 13.8 0.0 6.9 6.2 0.0 2.2 2 0 0 2 2 2 0 DeoR C terminal sensor domain PPR_2 PF13041.1 CCF32201.1 - 1.5e-29 101.6 8.3 2.3e-09 37.1 0.0 10.0 5 2 6 11 11 11 6 PPR repeat family PPR_3 PF13812.1 CCF32201.1 - 1.7e-17 62.1 13.9 0.0018 18.3 0.0 10.8 11 0 0 11 11 11 4 Pentatricopeptide repeat domain PPR_1 PF12854.2 CCF32201.1 - 7.6e-16 57.3 0.0 8.6e-09 34.7 0.0 6.2 6 0 0 6 6 6 3 PPR repeat PPR PF01535.15 CCF32201.1 - 8.8e-16 56.7 21.6 0.00015 21.4 0.0 10.3 11 1 0 11 11 11 4 PPR repeat TPR_7 PF13176.1 CCF32201.1 - 0.064 13.0 0.5 1.9 8.4 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TMEM51 PF15345.1 CCF32202.1 - 0.0068 16.1 0.2 0.0068 16.1 0.1 1.2 1 0 0 1 1 1 1 Transmembrane protein 51 PepSY_TM PF03929.11 CCF32202.1 - 0.016 15.5 0.2 0.019 15.2 0.1 1.2 1 0 0 1 1 1 0 PepSY-associated TM helix Herpes_gE PF02480.11 CCF32202.1 - 0.055 11.7 1.1 0.054 11.7 0.8 1.0 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Ni_hydr_CYTB PF01292.15 CCF32202.1 - 0.063 12.6 0.0 0.063 12.6 0.0 1.1 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 DUF1469 PF07332.6 CCF32202.1 - 0.08 12.6 1.4 0.084 12.6 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) Ninjurin PF04923.7 CCF32202.1 - 0.13 11.9 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Ninjurin Shisa PF13908.1 CCF32202.1 - 0.15 12.2 0.2 0.15 12.2 0.1 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator PepSY_TM_1 PF13172.1 CCF32202.1 - 0.8 9.5 3.5 1.2 8.9 2.4 1.3 1 0 0 1 1 1 0 PepSY-associated TM helix Aminotran_5 PF00266.14 CCF32203.1 - 4.3e-31 107.9 0.0 6.5e-21 74.4 0.0 2.3 1 1 2 3 3 3 2 Aminotransferase class-V DnaJ PF00226.26 CCF32203.1 - 0.14 11.9 0.2 0.34 10.6 0.1 1.8 1 1 0 1 1 1 0 DnaJ domain Sulfate_transp PF00916.15 CCF32204.1 - 1.4e-07 30.8 4.9 2.9e-07 29.8 3.1 1.8 1 1 0 1 1 1 1 Sulfate transporter family Methyltransf_26 PF13659.1 CCF32206.1 - 1e-11 44.8 0.1 4.8e-11 42.7 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF32206.1 - 1.3e-07 31.3 0.0 3.3e-07 30.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF32206.1 - 9.6e-06 26.1 0.0 1.8e-05 25.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF32206.1 - 1.7e-05 24.2 0.0 4.6e-05 22.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain N6_Mtase PF02384.11 CCF32206.1 - 0.0096 15.0 0.0 0.014 14.4 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_32 PF13679.1 CCF32206.1 - 0.0098 15.5 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 CCF32206.1 - 0.01 14.9 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.1 CCF32206.1 - 0.014 15.7 0.0 0.037 14.3 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain UPF0020 PF01170.13 CCF32206.1 - 0.13 11.8 0.0 0.35 10.4 0.0 1.6 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_23 PF13489.1 CCF32206.1 - 0.16 11.6 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain WD40 PF00400.27 CCF32207.1 - 5.5e-24 83.1 5.5 1.1e-05 25.0 0.0 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat PQQ_2 PF13360.1 CCF32207.1 - 0.0016 17.9 3.7 0.38 10.1 0.0 2.6 1 1 1 2 2 2 2 PQQ-like domain PQQ_3 PF13570.1 CCF32207.1 - 0.054 13.7 9.0 2.3 8.6 0.2 4.3 4 0 0 4 4 4 0 PQQ-like domain PQQ PF01011.16 CCF32207.1 - 0.076 12.5 0.3 10 5.8 0.0 3.6 4 0 0 4 4 4 0 PQQ enzyme repeat Glyco_transf_15 PF01793.11 CCF32208.1 - 3.8e-138 459.9 9.9 4.6e-138 459.6 6.9 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Transferase PF02458.10 CCF32210.1 - 4.5e-05 22.0 0.0 0.0019 16.6 0.0 2.5 2 1 0 2 2 2 2 Transferase family tRNA-synt_2 PF00152.15 CCF32211.1 - 1.1e-75 254.4 0.0 1.9e-75 253.7 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.4 CCF32211.1 - 1.7e-14 53.3 0.2 2.6e-14 52.7 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2156) tRNA_anti-codon PF01336.20 CCF32211.1 - 7.4e-09 35.3 0.0 2.1e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain SR-25 PF10500.4 CCF32211.1 - 0.93 8.9 23.9 0.018 14.5 12.0 1.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SOBP PF15279.1 CCF32211.1 - 1.1 9.5 6.1 1.9 8.7 4.2 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein CRC_subunit PF08624.5 CCF32212.1 - 4.6e-54 182.1 0.0 6.4e-54 181.6 0.0 1.2 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Actin PF00022.14 CCF32213.1 - 3.5e-101 338.4 0.0 4.2e-101 338.2 0.0 1.0 1 0 0 1 1 1 1 Actin Cupin_1 PF00190.17 CCF32214.1 - 2.7e-12 46.3 0.0 3.9e-12 45.8 0.0 1.1 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.6 CCF32214.1 - 3.3e-05 23.3 0.0 6.9e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 Cupin domain F-box PF00646.28 CCF32215.1 - 0.095 12.3 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 F-box domain DPM3 PF08285.6 CCF32217.1 - 3.1e-33 113.4 0.2 3.5e-33 113.3 0.1 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) RhgB_N PF09284.5 CCF32218.1 - 2.1e-97 325.3 0.0 2.8e-97 324.9 0.0 1.2 1 0 0 1 1 1 1 Rhamnogalacturonase B, N-terminal CBM-like PF14683.1 CCF32218.1 - 1.8e-49 167.5 0.0 3.3e-49 166.7 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.1 CCF32218.1 - 8.7e-14 51.4 0.6 2.1e-13 50.1 0.4 1.7 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.1 CCF32218.1 - 0.0085 16.1 1.1 0.0085 16.1 0.8 2.3 3 1 0 3 3 3 1 Carboxypeptidase regulatory-like domain DUF3823 PF12866.2 CCF32218.1 - 0.11 12.0 0.1 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3823) Acylphosphatase PF00708.13 CCF32218.1 - 0.14 12.3 0.0 0.91 9.6 0.0 2.2 2 0 0 2 2 2 0 Acylphosphatase WSC PF01822.14 CCF32219.1 - 4.5e-55 183.5 51.2 1.2e-19 70.0 5.4 5.0 4 0 0 4 4 4 4 WSC domain PQQ_3 PF13570.1 CCF32219.1 - 1.9 8.8 10.5 7.2 7.0 0.0 5.2 5 0 0 5 5 5 0 PQQ-like domain DUF605 PF04652.11 CCF32219.1 - 4.6 6.5 31.3 0.16 11.2 8.6 2.2 2 0 0 2 2 2 0 Vta1 like Peptidase_M20 PF01546.23 CCF32220.1 - 4.3e-19 68.7 0.0 4.3e-10 39.4 0.0 2.2 2 0 0 2 2 2 2 Peptidase family M20/M25/M40 M20_dimer PF07687.9 CCF32220.1 - 7.4e-06 25.6 0.0 1.6e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain ELMO_CED12 PF04727.8 CCF32221.1 - 4.2e-49 166.3 0.1 1.4e-48 164.6 0.0 1.8 2 0 0 2 2 2 1 ELMO/CED-12 family DUF3361 PF11841.3 CCF32221.1 - 0.00059 19.5 0.1 0.047 13.4 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF3361) zf-GRF PF06839.7 CCF32222.1 - 2.4e-09 36.9 6.2 3.8e-09 36.3 4.3 1.3 1 0 0 1 1 1 1 GRF zinc finger Prefoldin_2 PF01920.15 CCF32222.1 - 0.0023 17.6 0.3 0.0044 16.7 0.2 1.4 1 0 0 1 1 1 1 Prefoldin subunit TMF_DNA_bd PF12329.3 CCF32222.1 - 0.0043 16.8 0.6 0.0043 16.8 0.4 1.8 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding bZIP_1 PF00170.16 CCF32222.1 - 0.026 14.4 0.4 0.026 14.4 0.3 1.8 2 0 0 2 2 2 0 bZIP transcription factor Med9 PF07544.8 CCF32222.1 - 0.031 14.0 0.3 0.076 12.7 0.2 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DivIC PF04977.10 CCF32222.1 - 0.12 11.8 0.6 0.3 10.6 0.4 1.6 1 0 0 1 1 1 0 Septum formation initiator Nucleo_P87 PF07267.6 CCF32222.1 - 8.1 4.9 7.4 0.65 8.6 1.3 1.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 DUF3818 PF12825.2 CCF32223.1 - 1.4e-135 451.3 3.5 2.1e-135 450.8 2.4 1.2 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.2 CCF32223.1 - 7.2e-43 145.4 1.7 1.1e-42 144.9 0.3 1.9 2 0 0 2 2 2 1 PX-associated PX PF00787.19 CCF32223.1 - 2.6e-14 52.9 0.0 1.4e-13 50.6 0.0 2.3 2 1 0 2 2 2 1 PX domain Myc_N PF01056.13 CCF32223.1 - 0.00077 18.7 2.3 0.0014 17.9 1.6 1.3 1 0 0 1 1 1 1 Myc amino-terminal region DUF1514 PF07438.6 CCF32224.1 - 0.03 14.2 0.2 0.07 13.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1514) DUF2077 PF09850.4 CCF32224.1 - 0.075 12.4 1.0 0.18 11.2 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2077) Fib_alpha PF08702.5 CCF32224.1 - 0.1 12.7 0.3 0.42 10.7 0.2 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Cgr1 PF03879.9 CCF32225.1 - 7.8e-39 132.2 33.7 9.3e-39 131.9 23.4 1.0 1 0 0 1 1 1 1 Cgr1 family TROVE PF05731.6 CCF32225.1 - 2.5 6.7 15.8 2.6 6.6 11.0 1.0 1 0 0 1 1 1 0 TROVE domain RR_TM4-6 PF06459.7 CCF32225.1 - 2.5 7.9 17.6 2.6 7.8 12.2 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PRP1_N PF06424.7 CCF32225.1 - 5.6 7.2 17.3 7 6.9 12.0 1.3 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal Silic_transp PF03842.8 CCF32225.1 - 8.7 4.2 6.4 8.3 4.3 4.4 1.1 1 0 0 1 1 1 0 Silicon transporter Sulfatase PF00884.18 CCF32226.1 - 3.9e-17 62.3 0.0 7.3e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.17 CCF32226.1 - 3e-05 23.4 0.0 5.4e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.12 CCF32226.1 - 0.048 12.0 0.0 0.078 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Glyco_hydro_11 PF00457.12 CCF32229.1 - 9.4e-78 259.7 23.9 1.1e-77 259.5 16.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 HAD_2 PF13419.1 CCF32230.1 - 3.4e-23 82.7 0.0 4.3e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CCF32230.1 - 0.001 19.5 0.0 0.057 13.8 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.1 CCF32230.1 - 0.031 14.1 0.0 7.5 6.5 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DAO PF01266.19 CCF32231.1 - 1.6e-49 168.7 0.1 1.9e-49 168.4 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 CCF32231.1 - 0.00013 22.1 0.0 0.12 12.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF32231.1 - 0.0018 18.0 1.3 0.22 11.2 0.1 2.6 3 0 0 3 3 3 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 CCF32231.1 - 0.079 13.0 0.1 0.18 11.8 0.1 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DUF4243 PF14027.1 CCF32232.1 - 3.4e-71 240.3 0.5 4.9e-71 239.8 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4243) MFS_1 PF07690.11 CCF32233.1 - 3.6e-43 147.6 35.6 3.6e-43 147.6 24.7 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily RskA PF10099.4 CCF32233.1 - 0.047 13.4 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 Anti-sigma-K factor rskA OATP PF03137.15 CCF32233.1 - 0.097 10.6 10.0 0.44 8.5 0.7 3.1 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF2583 PF10762.4 CCF32233.1 - 0.51 10.5 2.7 0.87 9.7 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2583) Peptidase_S15 PF02129.13 CCF32234.1 - 1.5e-29 103.2 0.1 5.3e-25 88.3 0.0 3.1 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.5 CCF32234.1 - 6.1e-10 39.3 0.8 1.1e-05 25.4 0.0 2.8 3 0 0 3 3 3 2 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain HSP70 PF00012.15 CCF32235.1 - 1.6e-07 29.6 0.0 2.5e-05 22.4 0.0 2.4 2 1 0 2 2 2 2 Hsp70 protein FGGY_C PF02782.11 CCF32235.1 - 0.00011 21.9 0.0 0.00044 19.9 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain MreB_Mbl PF06723.8 CCF32235.1 - 0.022 13.3 0.0 0.1 11.1 0.0 1.9 1 1 0 1 1 1 0 MreB/Mbl protein AIG1 PF04548.11 CCF32236.1 - 1.5e-10 40.5 0.0 3.1e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 CCF32236.1 - 1.9e-07 31.0 0.1 5.2e-07 29.6 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase Septin PF00735.13 CCF32236.1 - 4e-05 22.7 0.0 8.4e-05 21.7 0.0 1.5 1 0 0 1 1 1 1 Septin DUF258 PF03193.11 CCF32236.1 - 0.00082 18.5 0.2 0.0028 16.8 0.1 1.9 1 1 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 CCF32236.1 - 0.00095 19.0 3.0 1.9 8.2 0.0 3.8 3 1 1 4 4 4 2 Dynamin family SRPRB PF09439.5 CCF32236.1 - 0.0014 17.9 2.3 0.0029 16.8 0.0 2.3 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_30 PF13604.1 CCF32236.1 - 0.0037 16.8 0.0 0.0096 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CCF32236.1 - 0.0052 16.9 0.0 0.019 15.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CCF32236.1 - 0.006 17.3 0.2 0.11 13.3 0.2 2.5 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 CCF32236.1 - 0.0068 15.9 0.0 0.14 11.6 0.0 2.2 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase FtsK_SpoIIIE PF01580.13 CCF32236.1 - 0.0089 15.5 1.0 0.23 10.9 0.0 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_33 PF13671.1 CCF32236.1 - 0.0089 15.9 0.1 0.19 11.6 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_14 PF13173.1 CCF32236.1 - 0.03 14.2 0.0 0.1 12.5 0.0 1.9 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 CCF32236.1 - 0.044 14.0 0.7 0.44 10.8 0.0 2.3 2 1 0 2 2 2 0 ABC transporter AAA_16 PF13191.1 CCF32236.1 - 0.047 13.6 0.2 0.12 12.3 0.0 1.8 2 1 0 2 2 2 0 AAA ATPase domain GBP PF02263.14 CCF32236.1 - 0.052 12.5 2.7 0.098 11.6 0.0 2.3 3 0 0 3 3 3 0 Guanylate-binding protein, N-terminal domain Miro PF08477.8 CCF32236.1 - 0.063 13.7 0.2 0.41 11.1 0.0 2.3 2 0 0 2 2 2 0 Miro-like protein AAA_10 PF12846.2 CCF32236.1 - 0.1 12.0 0.3 0.21 10.9 0.2 1.9 1 1 0 1 1 1 0 AAA-like domain DUF87 PF01935.12 CCF32236.1 - 0.63 9.8 6.3 0.72 9.6 0.1 3.0 1 1 2 3 3 3 0 Domain of unknown function DUF87 AAA_23 PF13476.1 CCF32236.1 - 1.8 8.8 10.9 1.4e+02 2.6 7.5 2.4 1 1 0 1 1 1 0 AAA domain XPG_N PF00752.12 CCF32237.1 - 5.7e-05 23.3 0.0 0.00016 21.8 0.0 1.7 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.13 CCF32237.1 - 0.072 13.1 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 XPG I-region DNMT1-RFD PF12047.3 CCF32238.1 - 0.014 15.0 0.0 0.028 14.1 0.0 1.6 1 0 0 1 1 1 0 Cytosine specific DNA methyltransferase replication foci domain TruB_N PF01509.13 CCF32239.1 - 2.1e-45 154.5 0.0 6e-45 153.0 0.0 1.7 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) Sec2p PF06428.6 CCF32240.1 - 7.2e-12 45.0 9.1 9.1e-12 44.7 6.3 1.2 1 0 0 1 1 1 1 GDP/GTP exchange factor Sec2p UPF0449 PF15136.1 CCF32240.1 - 0.0075 16.4 0.2 0.013 15.7 0.2 1.3 1 0 0 1 1 1 1 Uncharacterised protein family UPF0449 SlyX PF04102.7 CCF32240.1 - 0.17 12.2 5.8 0.35 11.2 3.1 2.2 1 1 1 2 2 2 0 SlyX Lzipper-MIP1 PF14389.1 CCF32240.1 - 0.19 11.8 9.5 0.39 10.8 0.8 2.2 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 MbeD_MobD PF04899.7 CCF32240.1 - 0.27 11.1 7.7 1.6 8.6 4.6 2.1 1 1 1 2 2 2 0 MbeD/MobD like FliT PF05400.8 CCF32240.1 - 0.29 11.5 11.2 0.49 10.8 0.0 3.0 1 1 2 3 3 3 0 Flagellar protein FliT IncA PF04156.9 CCF32240.1 - 0.8 9.2 8.8 0.98 8.9 6.1 1.2 1 0 0 1 1 1 0 IncA protein Latarcin PF10279.4 CCF32240.1 - 2.6 8.2 6.9 5.1 7.3 4.8 1.8 1 1 0 1 1 1 0 Latarcin precursor HR1 PF02185.11 CCF32240.1 - 3.6 7.4 10.9 2.4 7.9 4.1 2.4 2 1 0 2 2 2 0 Hr1 repeat Fungal_trans PF04082.13 CCF32241.1 - 6.9e-16 57.8 0.1 1.2e-15 57.1 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 CCF32241.1 - 4e-09 36.2 13.6 0.00017 21.7 1.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CCF32241.1 - 5.8e-06 26.3 7.4 5.8e-06 26.3 5.2 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 CCF32241.1 - 0.0085 16.3 18.8 0.11 12.8 2.2 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.2 CCF32241.1 - 0.08 13.1 1.3 0.23 11.7 0.9 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 CCF32241.1 - 9.6 6.2 8.3 2.7 8.0 0.7 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger TPR_19 PF14559.1 CCF32242.1 - 7.5e-05 22.9 0.5 0.0093 16.2 0.1 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat NPV_P10 PF05531.7 CCF32242.1 - 0.0033 17.6 2.1 0.008 16.3 0.7 2.3 2 0 0 2 2 2 1 Nucleopolyhedrovirus P10 protein TPR_12 PF13424.1 CCF32242.1 - 0.0057 16.5 0.3 0.2 11.6 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat Big_3_3 PF13750.1 CCF32242.1 - 0.01 15.2 0.7 0.14 11.5 0.0 2.4 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) DUF948 PF06103.6 CCF32242.1 - 0.15 11.8 1.2 0.49 10.2 0.8 1.9 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) NACHT PF05729.7 CCF32243.1 - 3e-13 49.7 0.4 6.9e-13 48.5 0.3 1.6 1 0 0 1 1 1 1 NACHT domain PNP_UDP_1 PF01048.15 CCF32243.1 - 1.6e-11 43.6 1.0 5.3e-11 41.9 0.7 1.8 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_16 PF13191.1 CCF32243.1 - 4.3e-07 30.1 0.0 1e-06 28.8 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.17 CCF32243.1 - 2.2e-06 26.7 0.0 3.5e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain Arch_ATPase PF01637.13 CCF32243.1 - 1e-05 25.3 0.0 1.7e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase AAA_22 PF13401.1 CCF32243.1 - 1.5e-05 25.1 0.0 3.5e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.9 CCF32243.1 - 0.0032 16.5 0.4 0.21 10.5 0.0 2.2 1 1 1 2 2 2 1 KAP family P-loop domain APS_kinase PF01583.15 CCF32243.1 - 0.042 13.5 0.0 0.099 12.2 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_33 PF13671.1 CCF32243.1 - 0.054 13.3 0.0 0.14 12.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 CCF32243.1 - 0.06 13.5 0.0 0.17 12.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase NOZZLE PF08744.5 CCF32243.1 - 0.071 12.4 0.1 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Plant transcription factor NOZZLE Synaptobrevin PF00957.16 CCF32244.1 - 2.8e-33 113.3 0.7 3.3e-33 113.1 0.5 1.0 1 0 0 1 1 1 1 Synaptobrevin AA_kinase PF00696.23 CCF32245.1 - 1.1e-27 97.1 0.0 1.9e-27 96.4 0.0 1.3 1 0 0 1 1 1 1 Amino acid kinase family DUF619 PF04768.8 CCF32245.1 - 1.8e-10 40.5 0.1 1.5e-09 37.5 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF619) Glyco_hydro_16 PF00722.16 CCF32246.1 - 1.3e-44 151.7 1.0 1.9e-44 151.1 0.7 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Topoisom_I_N PF02919.10 CCF32247.1 - 5.1e-96 320.0 4.7 5.1e-96 320.0 3.3 2.7 4 0 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.15 CCF32247.1 - 5.2e-84 281.0 7.2 5.2e-84 281.0 5.0 2.0 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.1 CCF32247.1 - 2.2e-30 104.1 0.4 6.1e-30 102.7 0.3 1.8 1 0 0 1 1 1 1 C-terminal topoisomerase domain RolB_RolC PF02027.12 CCF32247.1 - 0.046 12.8 0.1 0.1 11.7 0.1 1.5 1 0 0 1 1 1 0 RolB/RolC glucosidase family ATP-synt PF00231.14 CCF32248.1 - 1.8e-51 175.2 0.3 2e-51 175.0 0.2 1.0 1 0 0 1 1 1 1 ATP synthase MFS_1 PF07690.11 CCF32249.1 - 6.8e-25 87.5 59.1 1e-18 67.2 32.8 3.2 1 1 1 2 2 2 2 Major Facilitator Superfamily ATP-synt_J PF04911.7 CCF32249.1 - 0.11 11.9 0.1 0.56 9.7 0.0 2.3 2 0 0 2 2 2 0 ATP synthase j chain AMP-binding PF00501.23 CCF32250.1 - 1.2e-82 277.5 0.1 1.7e-82 277.0 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF32250.1 - 2.9e-07 31.3 0.0 6.9e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain adh_short PF00106.20 CCF32251.1 - 2.6e-08 33.9 0.0 4.8e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.16 CCF32251.1 - 1.1e-06 28.2 0.0 1.9e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 CCF32251.1 - 1.1e-05 25.3 0.0 1.3e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF32251.1 - 0.00036 20.2 0.0 0.00053 19.6 0.0 1.4 1 1 0 1 1 1 1 KR domain Semialdhyde_dh PF01118.19 CCF32251.1 - 0.12 12.6 0.0 3.2 8.0 0.0 2.5 2 1 0 3 3 3 0 Semialdehyde dehydrogenase, NAD binding domain Fungal_trans_2 PF11951.3 CCF32252.1 - 6.9e-21 74.2 3.7 1.3e-19 70.0 2.5 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF32252.1 - 8.8e-06 25.5 8.0 1.5e-05 24.7 5.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_S8 PF00082.17 CCF32253.1 - 2.5e-29 102.3 17.1 2.8e-28 98.8 10.8 2.1 1 1 1 2 2 2 2 Subtilase family Inhibitor_I9 PF05922.11 CCF32253.1 - 2.7e-12 47.0 0.0 4.8e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Pyr_redox_2 PF07992.9 CCF32254.1 - 4.5e-18 65.8 0.0 4.6e-17 62.5 0.0 3.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF32254.1 - 1.2e-09 38.3 0.1 7.5e-09 35.8 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF32254.1 - 0.016 15.1 0.0 8.8 6.4 0.0 3.3 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CCF32254.1 - 0.031 13.1 0.1 0.46 9.2 0.0 2.5 3 0 0 3 3 3 0 FAD binding domain p450 PF00067.17 CCF32256.1 - 2.4e-30 105.5 0.0 1.6e-29 102.7 0.0 1.9 1 1 0 1 1 1 1 Cytochrome P450 DUF3328 PF11807.3 CCF32257.1 - 1.8e-15 57.2 3.1 3e-15 56.5 2.1 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) ADH_zinc_N PF00107.21 CCF32258.1 - 6.8e-12 45.0 0.1 1e-11 44.4 0.1 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF32258.1 - 0.0039 18.0 0.1 0.016 16.1 0.0 2.0 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Herpes_UL45 PF05473.7 CCF32259.1 - 0.0001 21.8 0.0 0.00011 21.7 0.0 1.0 1 0 0 1 1 1 1 UL45 protein AAA_25 PF13481.1 CCF32260.1 - 0.022 14.1 0.1 0.075 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain Macro PF01661.16 CCF32261.1 - 2.4e-23 82.2 0.0 5e-23 81.2 0.0 1.5 2 0 0 2 2 2 1 Macro domain Fungal_trans PF04082.13 CCF32262.1 - 2.9e-09 36.1 0.1 8.4e-09 34.6 0.1 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain HET PF06985.6 CCF32263.1 - 2.3e-22 79.6 0.1 2.3e-22 79.6 0.1 2.4 3 0 0 3 3 3 1 Heterokaryon incompatibility protein (HET) Lipase_GDSL_2 PF13472.1 CCF32264.1 - 4.2e-11 43.3 0.0 1.4e-10 41.6 0.0 1.9 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family fn3 PF00041.16 CCF32264.1 - 2.5e-10 40.3 4.7 0.0011 19.0 0.0 3.7 3 2 0 3 3 3 3 Fibronectin type III domain Lipase_GDSL PF00657.17 CCF32264.1 - 0.00016 21.6 0.0 0.0013 18.5 0.0 2.2 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase ChitinaseA_N PF08329.5 CCF32264.1 - 0.002 17.9 0.2 1 9.1 0.1 2.5 1 1 1 2 2 2 2 Chitinase A, N-terminal domain PP2C PF00481.16 CCF32265.1 - 0.00048 19.5 0.0 0.00068 19.1 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C BTB PF00651.26 CCF32266.1 - 0.0018 18.2 0.2 1 9.4 0.0 2.8 2 0 0 2 2 2 2 BTB/POZ domain FTR1 PF03239.9 CCF32267.1 - 5.8e-82 275.0 8.5 7e-82 274.7 5.9 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family BioY PF02632.9 CCF32267.1 - 0.016 14.8 3.3 0.016 14.8 2.3 2.9 1 1 2 3 3 3 0 BioY family Chs3p PF12271.3 CCF32267.1 - 0.022 13.7 1.7 0.038 12.9 1.2 1.5 1 0 0 1 1 1 0 Chitin synthase III catalytic subunit DUF4231 PF14015.1 CCF32267.1 - 2.7 8.0 6.9 0.16 11.9 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Cu-oxidase_3 PF07732.10 CCF32268.1 - 1.7e-41 140.6 4.5 4.1e-41 139.4 0.7 2.7 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.17 CCF32268.1 - 8.1e-41 139.5 1.6 8.5e-36 123.2 0.1 2.7 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.9 CCF32268.1 - 3.1e-24 85.0 4.5 4.3e-19 68.3 0.0 3.3 3 1 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.1 CCF32268.1 - 0.011 15.5 0.0 1.7 8.5 0.0 3.1 3 1 0 3 3 3 0 Cupredoxin-like domain Med3 PF11593.3 CCF32269.1 - 2.3 7.3 12.8 3.3 6.8 8.9 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF2196 PF09962.4 CCF32271.1 - 1.9e-22 78.7 3.2 2.8e-22 78.2 2.2 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2196) TOBE_2 PF08402.5 CCF32271.1 - 0.019 14.9 1.2 0.034 14.1 0.8 1.5 1 0 0 1 1 1 0 TOBE domain SSrecog PF03531.9 CCF32272.1 - 9.1e-77 257.3 0.2 8.2e-76 254.2 0.1 2.1 1 1 0 1 1 1 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.7 CCF32272.1 - 1.3e-24 86.0 0.1 2e-23 82.1 0.0 2.7 3 0 0 3 3 3 1 Histone chaperone Rttp106-like DUF2201_N PF13203.1 CCF32272.1 - 0.16 11.1 0.0 0.16 11.1 0.0 2.1 2 0 0 2 2 2 0 Putative metallopeptidase domain BUD22 PF09073.5 CCF32272.1 - 2.9 6.8 23.4 4.7 6.1 16.2 1.3 1 0 0 1 1 1 0 BUD22 AMP-binding PF00501.23 CCF32273.1 - 1.5e-70 237.6 0.0 1.9e-70 237.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF32273.1 - 4.8e-17 62.6 0.0 9.4e-17 61.7 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Glyco_hydro_76 PF03663.9 CCF32275.1 - 9.6e-22 77.8 4.4 1.4e-20 74.0 0.4 3.0 2 1 0 2 2 2 1 Glycosyl hydrolase family 76 DUF4175 PF13779.1 CCF32276.1 - 0.34 8.5 11.0 0.42 8.2 7.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Ribophorin_II PF05817.9 CCF32277.1 - 1.2e-26 93.1 0.0 1.5e-26 92.8 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II Peptidase_M28 PF04389.12 CCF32278.1 - 2.4e-26 92.5 0.0 3.1e-26 92.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 GTP_EFTU_D2 PF03144.20 CCF32279.1 - 0.041 13.9 0.2 0.34 11.0 0.0 2.5 3 0 0 3 3 3 0 Elongation factor Tu domain 2 Rab5ip PF07019.7 CCF32280.1 - 1.5e-22 79.5 5.4 1.8e-22 79.2 3.7 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) P5-ATPase PF12409.3 CCF32280.1 - 0.8 9.5 2.5 0.63 9.9 0.4 1.7 2 0 0 2 2 2 0 P5-type ATPase cation transporter Vezatin PF12632.2 CCF32281.1 - 2e-55 187.6 0.0 3.2e-55 186.9 0.0 1.4 1 0 0 1 1 1 1 Mysoin-binding motif of peroxisomes DUF4231 PF14015.1 CCF32281.1 - 0.00046 20.1 2.2 0.0094 15.9 1.1 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF4231) PCNA_N PF00705.13 CCF32282.1 - 4.2e-53 178.2 4.9 7.7e-53 177.3 2.3 2.0 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.10 CCF32282.1 - 4.8e-49 165.5 0.1 7.6e-49 164.8 0.0 1.3 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.8 CCF32282.1 - 2.7e-10 39.8 0.0 3.3e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 Rad9 Hus1 PF04005.7 CCF32282.1 - 6.8e-05 21.9 0.2 0.0032 16.4 0.0 2.2 2 1 0 2 2 2 1 Hus1-like protein DNA_pol3_beta_3 PF02768.10 CCF32282.1 - 0.15 11.6 0.4 0.57 9.7 0.0 2.2 3 1 0 3 3 3 0 DNA polymerase III beta subunit, C-terminal domain Phos_pyr_kin PF08543.7 CCF32283.1 - 2.4e-08 33.4 0.0 3.2e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.19 CCF32283.1 - 3.5e-08 32.9 0.4 6.4e-07 28.8 0.2 2.1 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Leader_CPA1 PF08252.6 CCF32284.1 - 8.1e-16 56.8 0.0 1.6e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 arg-2/CPA1 leader peptide GATase PF00117.23 CCF32285.1 - 3.2e-47 160.4 0.0 4.4e-47 160.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.17 CCF32285.1 - 6.1e-46 155.1 0.0 9.1e-46 154.5 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.8 CCF32285.1 - 1.7e-06 27.6 0.1 0.00022 20.7 0.1 2.6 1 1 0 1 1 1 1 Peptidase C26 SAP PF02037.22 CCF32286.1 - 1.7e-11 43.3 0.4 3e-11 42.5 0.3 1.5 1 0 0 1 1 1 1 SAP domain DUF719 PF05334.8 CCF32286.1 - 0.068 13.2 3.9 0.17 11.9 1.4 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF719) TPT PF03151.11 CCF32288.1 - 1.3e-26 93.0 12.9 1.3e-26 93.0 8.9 2.1 2 0 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 CCF32288.1 - 0.091 11.6 18.8 2.1 7.1 13.0 2.1 1 1 0 1 1 1 0 UAA transporter family EamA PF00892.15 CCF32288.1 - 2 8.4 31.6 0.33 10.9 8.5 3.0 3 1 0 3 3 3 0 EamA-like transporter family TENA_THI-4 PF03070.11 CCF32289.1 - 2.3e-10 40.5 0.0 0.00024 20.9 0.0 2.2 2 0 0 2 2 2 2 TENA/THI-4/PQQC family UCH PF00443.24 CCF32290.1 - 2.3e-38 131.8 0.0 3.3e-38 131.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CCF32290.1 - 3.9e-05 23.2 0.0 9e-05 22.0 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Alb1 PF09135.6 CCF32291.1 - 7.1e-23 81.3 19.1 7.1e-23 81.3 13.2 1.6 2 0 0 2 2 2 1 Alb1 Peptidase_M90 PF06167.7 CCF32291.1 - 0.043 13.1 0.6 0.055 12.8 0.4 1.2 1 0 0 1 1 1 0 Glucose-regulated metallo-peptidase M90 Tho2 PF11262.3 CCF32291.1 - 0.61 9.0 3.8 0.77 8.7 2.6 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 ABC_tran_2 PF12848.2 CCF32291.1 - 2.7 7.8 10.0 5.1 7.0 6.9 1.5 1 0 0 1 1 1 0 ABC transporter DUF4570 PF15134.1 CCF32291.1 - 4.3 7.2 8.3 2.5 8.0 3.9 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4570) DUF4551 PF15087.1 CCF32291.1 - 5 5.3 8.8 5.6 5.2 6.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) LysM PF01476.15 CCF32292.1 - 0.00023 21.0 0.0 0.0016 18.3 0.0 2.0 2 0 0 2 2 2 1 LysM domain EB PF01683.13 CCF32292.1 - 0.047 13.7 0.7 12 6.1 0.0 2.6 3 0 0 3 3 3 0 EB module Lamp PF01299.12 CCF32292.1 - 0.067 12.3 1.0 0.073 12.1 0.7 1.1 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) Tom37 PF10568.4 CCF32292.1 - 0.29 11.4 1.2 4.6 7.5 0.1 2.6 3 0 0 3 3 3 0 Outer mitochondrial membrane transport complex protein Sporozoite_P67 PF05642.6 CCF32292.1 - 2.1 6.1 4.4 2.5 5.8 3.1 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen His_Phos_1 PF00300.17 CCF32293.1 - 2.8e-15 56.7 0.0 4.9e-15 55.9 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) CTP_transf_2 PF01467.21 CCF32294.1 - 1.5e-18 67.3 0.0 1.1e-14 54.7 0.0 3.9 3 1 0 3 3 3 2 Cytidylyltransferase Aminotran_4 PF01063.14 CCF32295.1 - 1.2e-21 77.3 0.0 1.6e-21 76.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class IV DEK_C PF08766.6 CCF32295.1 - 0.16 11.7 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 DEK C terminal domain SPC25 PF06703.6 CCF32297.1 - 0.82 9.2 12.4 1.1 8.8 0.2 2.8 2 1 1 3 3 3 0 Microsomal signal peptidase 25 kDa subunit (SPC25) PalH PF08733.5 CCF32297.1 - 0.91 8.2 11.1 1.5 7.5 4.2 2.1 1 1 1 2 2 2 0 PalH/RIM21 MFS_1 PF07690.11 CCF32297.1 - 4.2 5.9 15.1 0.087 11.5 2.7 2.1 1 1 0 2 2 2 0 Major Facilitator Superfamily DUF4149 PF13664.1 CCF32297.1 - 7.2 6.7 15.0 1.1 9.3 2.9 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4149) PBP1_TM PF14812.1 CCF32298.1 - 2.9 8.2 10.6 0.057 13.7 2.5 1.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Peptidase_M49 PF03571.10 CCF32300.1 - 2e-230 765.5 0.0 2.4e-230 765.3 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M49 Ribosomal_L6e PF01159.14 CCF32301.1 - 5.1e-38 129.6 0.4 8.6e-38 128.9 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L6e Gmx_para_CXXCG PF09535.5 CCF32301.1 - 0.092 11.7 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (Gmx_para_CXXCG) AAA_2 PF07724.9 CCF32302.1 - 1.6e-32 112.7 0.0 6.8e-30 104.2 0.0 3.4 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.4 CCF32302.1 - 1.1e-15 57.2 0.0 4.3e-15 55.3 0.0 2.0 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.24 CCF32302.1 - 3.1e-15 56.5 0.1 8.8e-10 38.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF32302.1 - 1.3e-10 41.5 5.0 0.00083 19.3 0.0 4.0 3 1 1 4 4 4 3 AAA ATPase domain AAA_22 PF13401.1 CCF32302.1 - 1.2e-07 31.9 1.1 0.0011 19.0 0.0 3.0 3 0 0 3 3 2 2 AAA domain Arch_ATPase PF01637.13 CCF32302.1 - 1.4e-06 28.1 5.7 0.018 14.7 0.2 4.3 3 1 0 3 3 3 1 Archaeal ATPase AAA_5 PF07728.9 CCF32302.1 - 8.8e-05 22.2 0.2 0.17 11.5 0.0 3.2 4 0 0 4 4 2 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 CCF32302.1 - 9.3e-05 23.2 3.9 0.045 14.5 0.0 3.5 3 1 0 3 3 3 1 AAA domain AAA_18 PF13238.1 CCF32302.1 - 0.00011 22.5 5.0 0.14 12.5 0.0 3.3 3 0 0 3 3 3 2 AAA domain NACHT PF05729.7 CCF32302.1 - 0.00026 20.7 0.3 0.077 12.6 0.1 2.8 2 1 0 2 2 2 1 NACHT domain AAA_19 PF13245.1 CCF32302.1 - 0.00041 20.0 0.0 0.043 13.5 0.0 2.6 2 0 0 2 2 2 1 Part of AAA domain MobB PF03205.9 CCF32302.1 - 0.00044 19.9 0.1 0.23 11.1 0.0 2.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 CCF32302.1 - 0.00046 20.0 0.0 0.47 10.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 CCF32302.1 - 0.00071 19.0 0.0 0.65 9.3 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein ABC_tran PF00005.22 CCF32302.1 - 0.0017 18.6 2.0 0.4 10.9 0.0 3.4 3 0 0 3 3 3 1 ABC transporter Sigma54_activat PF00158.21 CCF32302.1 - 0.0029 17.0 0.4 2.1 7.7 0.0 2.7 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_25 PF13481.1 CCF32302.1 - 0.0029 17.0 0.1 1 8.7 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 CCF32302.1 - 0.0032 17.3 0.0 3.4 7.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 CCF32302.1 - 0.007 16.5 0.0 1.1 9.4 0.0 2.7 2 0 0 2 2 2 1 RNA helicase PhoH PF02562.11 CCF32302.1 - 0.0078 15.4 0.1 0.18 11.0 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein AAA_28 PF13521.1 CCF32302.1 - 0.01 15.7 0.6 10 6.0 0.0 3.4 3 1 0 3 3 3 0 AAA domain Miro PF08477.8 CCF32302.1 - 0.012 16.1 0.1 0.78 10.2 0.0 2.6 2 0 0 2 2 2 0 Miro-like protein SRP54 PF00448.17 CCF32302.1 - 0.016 14.6 0.0 0.4 10.0 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF258 PF03193.11 CCF32302.1 - 0.022 13.9 0.0 2.8 7.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 TrwB_AAD_bind PF10412.4 CCF32302.1 - 0.024 13.2 0.1 2.1 6.8 0.0 2.6 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain V_ATPase_I PF01496.14 CCF32302.1 - 0.032 12.1 3.2 0.043 11.6 2.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_24 PF13479.1 CCF32302.1 - 0.035 13.7 0.2 3.9 6.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 CCF32302.1 - 0.037 13.5 0.0 0.94 8.9 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_10 PF12846.2 CCF32302.1 - 0.048 13.0 0.6 0.84 9.0 0.0 2.9 2 1 1 3 3 3 0 AAA-like domain Mg_chelatase PF01078.16 CCF32302.1 - 0.067 12.3 0.0 2.1 7.4 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ResIII PF04851.10 CCF32302.1 - 0.07 12.9 4.4 6.7 6.4 0.0 3.4 3 1 1 4 4 4 0 Type III restriction enzyme, res subunit ATP_bind_1 PF03029.12 CCF32302.1 - 0.08 12.4 0.1 1.5 8.2 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein HlyD_2 PF12700.2 CCF32302.1 - 0.094 11.8 1.8 0.16 11.0 1.3 1.3 1 0 0 1 1 1 0 HlyD family secretion protein UvrD-helicase PF00580.16 CCF32302.1 - 0.094 12.0 4.1 0.18 11.0 0.1 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain Mnd1 PF03962.10 CCF32302.1 - 0.17 11.5 11.9 0.31 10.6 8.2 1.3 1 0 0 1 1 1 0 Mnd1 family Cortex-I_coil PF09304.5 CCF32302.1 - 0.33 11.0 10.9 1 9.4 7.6 1.8 1 0 0 1 1 1 0 Cortexillin I, coiled coil CENP-F_leu_zip PF10473.4 CCF32302.1 - 0.37 10.6 13.9 1.2 8.9 9.6 1.9 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GrpE PF01025.14 CCF32302.1 - 0.64 9.5 8.1 1.9 7.9 5.6 1.9 1 0 0 1 1 1 0 GrpE DUF3584 PF12128.3 CCF32302.1 - 0.69 7.1 10.3 1.1 6.4 7.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Atg14 PF10186.4 CCF32302.1 - 1 8.2 6.6 2.2 7.1 4.6 1.5 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 APG6 PF04111.7 CCF32302.1 - 1.1 8.2 8.8 2.1 7.2 6.1 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 CR6_interact PF10147.4 CCF32302.1 - 2.6 7.2 10.6 4.5 6.5 7.4 1.2 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 IncA PF04156.9 CCF32302.1 - 3.5 7.1 14.5 2.5 7.6 8.8 1.6 2 0 0 2 2 1 0 IncA protein Seryl_tRNA_N PF02403.17 CCF32302.1 - 3.8 7.5 17.2 0.59 10.1 6.5 2.9 3 1 0 3 3 1 0 Seryl-tRNA synthetase N-terminal domain AAA_23 PF13476.1 CCF32302.1 - 4.4 7.5 18.6 2.6e+02 1.7 0.0 3.1 2 1 0 2 2 2 0 AAA domain Ribosomal_L28e PF01778.12 CCF32303.1 - 2.6e-15 56.8 0.1 3.2e-15 56.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family DUF2015 PF09435.5 CCF32305.1 - 6.6e-48 161.7 0.0 7.3e-48 161.5 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) FA_hydroxylase PF04116.8 CCF32306.1 - 3.2e-13 50.0 17.8 3.2e-13 50.0 12.3 2.4 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Acyltransferase PF01553.16 CCF32307.1 - 1.2e-25 89.4 0.0 1.7e-25 88.9 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase LCCL PF03815.14 CCF32309.1 - 5.4e-19 67.9 0.1 7.9e-19 67.4 0.1 1.2 1 0 0 1 1 1 1 LCCL domain AMP-binding PF00501.23 CCF32310.1 - 3.5e-80 269.4 0.0 6.1e-80 268.6 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.7 CCF32310.1 - 1.3e-60 204.4 0.0 9e-60 201.6 0.0 2.2 2 0 0 2 2 2 1 Male sterility protein adh_short PF00106.20 CCF32310.1 - 4.4e-38 130.8 7.5 3.1e-34 118.3 2.4 2.9 3 0 0 3 3 3 2 short chain dehydrogenase KR PF08659.5 CCF32310.1 - 7.7e-22 77.8 4.2 1.5e-16 60.5 1.6 2.6 2 0 0 2 2 2 2 KR domain adh_short_C2 PF13561.1 CCF32310.1 - 3.2e-18 66.3 0.2 7.1e-18 65.2 0.2 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 CCF32310.1 - 2.2e-15 56.7 0.6 1e-08 34.8 0.0 3.3 3 1 0 3 3 3 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF32310.1 - 2.5e-11 43.9 0.6 2e-05 24.7 0.6 3.5 2 1 0 2 2 2 2 NADH(P)-binding PP-binding PF00550.20 CCF32310.1 - 3.5e-10 39.9 0.0 1.1e-09 38.4 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.14 CCF32310.1 - 1.7e-07 30.2 0.6 0.0002 20.1 0.0 3.0 2 1 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family AMP-binding_C PF13193.1 CCF32310.1 - 2.6e-07 31.4 0.1 2.9e-06 28.1 0.1 2.7 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Polysacc_synt_2 PF02719.10 CCF32310.1 - 4e-05 22.6 1.9 0.23 10.2 0.2 3.3 3 1 0 3 3 3 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.12 CCF32310.1 - 7.5e-05 21.7 4.4 0.0074 15.2 0.0 3.9 5 0 0 5 5 5 1 RmlD substrate binding domain THF_DHG_CYH_C PF02882.14 CCF32310.1 - 0.014 14.4 0.3 0.036 13.1 0.2 1.7 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DFP PF04127.10 CCF32310.1 - 0.016 14.8 1.1 0.036 13.6 0.8 1.5 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein NmrA PF05368.8 CCF32310.1 - 0.018 14.2 3.2 5.2 6.2 0.0 2.6 2 0 0 2 2 2 0 NmrA-like family Eno-Rase_NADH_b PF12242.3 CCF32310.1 - 0.16 11.8 2.2 0.43 10.3 1.5 1.7 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase RNA_pol_Rpb1_5 PF04998.12 CCF32312.1 - 1.9e-103 345.5 0.1 3e-103 344.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_6 PF04992.9 CCF32312.1 - 4.1e-54 183.1 4.4 7.1e-54 182.3 3.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.7 CCF32312.1 - 2.4e-44 150.3 5.7 8.5e-44 148.5 3.9 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.12 CCF32312.1 - 2.3e-37 127.0 0.1 5.2e-37 125.8 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_3 PF04983.13 CCF32312.1 - 1.2e-26 93.3 0.0 3.5e-26 91.8 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 Upf2 PF04050.9 CCF32312.1 - 0.02 14.6 1.2 0.045 13.5 0.8 1.5 1 0 0 1 1 1 0 Up-frameshift suppressor 2 DUF1236 PF06823.7 CCF32312.1 - 0.063 13.0 0.0 11 5.8 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1236) RNA_pol_Rpb1_R PF05001.8 CCF32312.1 - 2 8.7 200.1 0.039 14.0 9.2 13.7 9 2 3 13 13 13 0 RNA polymerase Rpb1 C-terminal repeat PRK PF00485.13 CCF32313.1 - 7.6e-55 185.4 0.0 1.1e-54 185.0 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.1 CCF32313.1 - 1.1e-41 142.3 0.0 1.6e-41 141.7 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_17 PF13207.1 CCF32313.1 - 1.3e-08 35.7 0.0 3.8e-08 34.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CCF32313.1 - 1.1e-06 28.9 0.0 3e-06 27.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CCF32313.1 - 3.8e-05 23.5 0.0 0.00058 19.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain CPT PF07931.7 CCF32313.1 - 5.8e-05 22.7 0.0 0.00011 21.8 0.0 1.5 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein ABC_tran PF00005.22 CCF32313.1 - 0.0026 18.0 0.2 0.0077 16.5 0.1 1.7 2 0 0 2 2 2 1 ABC transporter Pribosyltran PF00156.22 CCF32313.1 - 0.0038 16.9 0.2 0.027 14.1 0.0 2.3 3 0 0 3 3 3 1 Phosphoribosyl transferase domain AAA_29 PF13555.1 CCF32313.1 - 0.0062 16.0 0.1 0.015 14.8 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain MobB PF03205.9 CCF32313.1 - 0.012 15.3 0.0 0.04 13.6 0.0 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.7 CCF32313.1 - 0.014 14.4 0.0 0.028 13.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.1 CCF32313.1 - 0.019 14.9 0.6 0.11 12.4 0.1 2.2 2 1 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.17 CCF32313.1 - 0.02 13.7 0.0 0.032 13.0 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain DUF87 PF01935.12 CCF32313.1 - 0.049 13.4 0.0 0.097 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF87 Phasin_2 PF09361.5 CCF32313.1 - 0.06 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Phasin protein FtsK_SpoIIIE PF01580.13 CCF32313.1 - 0.098 12.1 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family APS_kinase PF01583.15 CCF32313.1 - 0.15 11.7 0.1 0.36 10.4 0.0 1.7 2 0 0 2 2 2 0 Adenylylsulphate kinase CLTH PF10607.4 CCF32315.1 - 5.1e-32 110.5 0.0 6.9e-32 110.1 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.6 CCF32315.1 - 1.3e-09 37.4 0.0 2.4e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 LisH ETC_C1_NDUFA4 PF04800.7 CCF32316.1 - 4.5e-36 122.7 0.9 7.3e-36 122.0 0.6 1.3 1 0 0 1 1 1 1 ETC complex I subunit conserved region Copper-bind PF00127.15 CCF32316.1 - 0.048 13.8 0.0 0.1 12.8 0.0 1.5 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family F1F0-ATPsyn_F PF10791.4 CCF32317.1 - 1.2e-42 144.0 0.2 1.4e-42 143.8 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.4 CCF32317.1 - 0.013 15.4 0.0 0.016 15.2 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f DUF3736 PF12540.3 CCF32322.1 - 0.42 10.8 3.3 0.92 9.7 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3736) PIP5K PF01504.13 CCF32326.1 - 2.1e-36 125.3 0.0 2.7e-36 124.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Acetyltransf_1 PF00583.19 CCF32327.1 - 8.6e-08 32.1 0.0 2e-07 30.9 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF32327.1 - 4.1e-05 23.6 0.0 9.3e-05 22.5 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CCF32327.1 - 0.00054 20.0 0.3 0.01 15.9 0.0 2.4 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 CCF32327.1 - 0.022 14.6 0.0 6.3 6.6 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain SUR7 PF06687.7 CCF32328.1 - 4.7e-14 52.4 2.0 5.9e-14 52.1 1.4 1.1 1 0 0 1 1 1 1 SUR7/PalI family Lactamase_B_2 PF12706.2 CCF32334.1 - 3.6e-39 134.3 0.1 4.7e-39 133.9 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 CCF32334.1 - 6.5e-09 35.7 0.0 9.3e-09 35.1 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 CCF32334.1 - 0.0011 18.6 1.0 0.0037 16.9 0.2 2.2 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily DUF1494 PF07379.6 CCF32335.1 - 0.047 13.6 0.1 0.047 13.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1494) Mst1_SARAH PF11629.3 CCF32335.1 - 0.33 10.7 3.5 0.34 10.7 0.4 2.0 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 DUF2207 PF09972.4 CCF32337.1 - 0.038 12.5 3.3 0.044 12.3 2.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) YlaC PF10777.4 CCF32337.1 - 0.075 12.5 1.0 0.11 12.0 0.7 1.3 1 0 0 1 1 1 0 Inner membrane protein YlaC SUR7 PF06687.7 CCF32337.1 - 7.2 6.1 11.9 9.9 5.6 8.2 1.3 1 0 0 1 1 1 0 SUR7/PalI family TRAM_LAG1_CLN8 PF03798.11 CCF32338.1 - 3.3e-37 127.9 11.4 5.5e-37 127.2 7.9 1.4 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.6 CCF32338.1 - 4.1e-19 67.8 0.0 8.8e-19 66.7 0.0 1.6 1 0 0 1 1 1 1 TRAM1-like protein Tubulin PF00091.20 CCF32339.1 - 5.1e-62 209.4 0.0 9.5e-62 208.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 CCF32339.1 - 7e-43 145.6 0.1 1.1e-42 145.0 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 CCF32339.1 - 0.0016 17.9 0.0 0.0029 17.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain DnaJ PF00226.26 CCF32340.1 - 8.2e-13 47.8 0.8 8.2e-13 47.8 0.5 2.7 2 1 0 2 2 2 1 DnaJ domain DUF4613 PF15390.1 CCF32340.1 - 0.043 12.0 3.8 0.054 11.6 2.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) DUF3037 PF11236.3 CCF32340.1 - 5.3 7.1 7.9 4.8 7.2 1.4 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3037) GCV_T PF01571.16 CCF32341.1 - 1.2e-14 54.2 0.1 4.5e-14 52.3 0.0 1.9 2 0 0 2 2 2 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 CCF32341.1 - 0.0079 16.1 0.0 0.019 14.9 0.0 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Kelch_5 PF13854.1 CCF32342.1 - 2.9e-10 39.8 4.4 3.3e-09 36.5 0.0 4.0 4 0 0 4 4 4 1 Kelch motif SKG6 PF08693.5 CCF32342.1 - 1.6e-06 27.3 0.8 2.9e-06 26.4 0.6 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Kelch_3 PF13415.1 CCF32342.1 - 6.5e-05 22.9 11.0 0.044 13.9 0.1 4.6 5 1 0 5 5 4 2 Galactose oxidase, central domain RCR PF12273.3 CCF32342.1 - 0.00034 21.1 0.0 0.0012 19.3 0.0 1.9 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red Kelch_6 PF13964.1 CCF32342.1 - 0.0015 18.5 6.9 0.58 10.4 0.4 4.7 3 2 1 4 4 4 1 Kelch motif Kelch_2 PF07646.10 CCF32342.1 - 0.013 15.2 4.0 2.8 7.8 0.6 4.1 4 2 0 4 4 4 0 Kelch motif DUF1191 PF06697.7 CCF32342.1 - 0.04 12.7 0.0 0.063 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) Kelch_4 PF13418.1 CCF32342.1 - 0.043 13.5 17.4 2.4 7.9 0.0 6.2 5 1 1 6 6 6 0 Galactose oxidase, central domain EphA2_TM PF14575.1 CCF32342.1 - 0.12 12.7 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.15 CCF32342.1 - 0.13 11.9 0.5 0.25 11.0 0.3 1.4 1 0 0 1 1 1 0 Syndecan domain Adeno_E3_CR2 PF02439.10 CCF32342.1 - 0.25 10.9 1.4 0.48 10.0 1.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Kelch_1 PF01344.20 CCF32342.1 - 0.3 10.6 3.3 11 5.6 1.1 3.8 3 1 0 3 3 3 0 Kelch motif SMC_N PF02463.14 CCF32343.1 - 7.7e-66 221.4 3.3 1.3e-65 220.7 2.3 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 CCF32343.1 - 1.8e-27 95.6 0.0 1.5e-26 92.7 0.0 2.7 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 CCF32343.1 - 2e-16 60.8 1.0 2.1e-07 31.2 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.1 CCF32343.1 - 4.1e-06 27.2 54.4 4.1e-06 27.2 37.7 7.8 2 2 1 3 3 3 1 AAA domain SbcCD_C PF13558.1 CCF32343.1 - 5.8e-05 22.9 0.5 0.00038 20.3 0.0 2.7 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 CCF32343.1 - 0.0005 19.5 0.0 0.0013 18.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.22 CCF32343.1 - 0.23 11.7 0.0 0.23 11.7 0.0 6.6 4 2 0 4 4 4 0 ABC transporter DUF948 PF06103.6 CCF32343.1 - 1.5 8.7 40.9 1.9 8.3 0.2 7.9 6 2 2 8 8 8 0 Bacterial protein of unknown function (DUF948) Reo_sigmaC PF04582.7 CCF32343.1 - 2.1 7.4 26.7 2.6 7.1 0.6 4.9 4 1 2 6 6 6 0 Reovirus sigma C capsid protein AAA_13 PF13166.1 CCF32343.1 - 3.3 6.0 94.6 0.45 8.9 10.7 5.4 4 1 1 5 5 5 0 AAA domain Complex1_LYR PF05347.10 CCF32344.1 - 6.1e-07 29.1 0.2 1.4e-06 27.9 0.0 1.6 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 CCF32344.1 - 4.1e-05 23.7 0.2 6.5e-05 23.0 0.2 1.6 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_2 PF13233.1 CCF32344.1 - 0.00047 20.5 0.1 0.00077 19.9 0.0 1.4 1 1 0 1 1 1 1 Complex1_LYR-like PMT_C PF11647.3 CCF32344.1 - 0.14 11.8 0.1 1.4 8.6 0.0 2.0 2 0 0 2 2 2 0 C-terminal region of Pasteurella multocida toxin residues 569-1285 OB_NTP_bind PF07717.11 CCF32345.1 - 1.5e-16 60.2 0.0 4.2e-16 58.7 0.0 1.7 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 CCF32345.1 - 5e-15 55.3 0.0 1.4e-14 53.9 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 CCF32345.1 - 6.1e-13 48.4 0.0 3.6e-12 45.9 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 CCF32345.1 - 3.3e-07 29.9 0.0 1.4e-06 27.8 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 CCF32345.1 - 0.0018 18.3 0.0 0.0054 16.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 CCF32345.1 - 0.0021 17.5 0.0 0.0049 16.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 CCF32345.1 - 0.0073 16.3 0.2 0.071 13.0 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain T2SE PF00437.15 CCF32345.1 - 0.019 13.8 0.0 0.034 13.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.22 CCF32345.1 - 0.023 15.0 0.0 0.11 12.8 0.0 2.2 2 0 0 2 2 2 0 ABC transporter Zeta_toxin PF06414.7 CCF32345.1 - 0.027 13.5 0.1 0.11 11.6 0.0 2.0 3 0 0 3 3 3 0 Zeta toxin G-alpha PF00503.15 CCF32345.1 - 0.061 11.9 0.4 0.15 10.6 0.3 1.6 1 0 0 1 1 1 0 G-protein alpha subunit AAA_23 PF13476.1 CCF32345.1 - 0.52 10.5 3.3 3.3 7.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain CBM_25 PF03423.8 CCF32346.1 - 0.13 12.3 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) SNARE PF05739.14 CCF32347.1 - 5.7e-05 22.7 3.3 5.7e-05 22.7 2.3 2.6 2 0 0 2 2 2 1 SNARE domain Usp PF00582.21 CCF32347.1 - 7 6.8 7.2 1.1 9.4 1.0 2.2 1 1 1 2 2 2 0 Universal stress protein family CAP_GLY PF01302.20 CCF32349.1 - 2.6e-18 65.4 0.6 3.5e-18 65.0 0.4 1.2 1 0 0 1 1 1 1 CAP-Gly domain HEAT_2 PF13646.1 CCF32350.1 - 0.057 13.7 0.0 0.17 12.1 0.0 1.7 1 1 0 1 1 1 0 HEAT repeats Nop14 PF04147.7 CCF32351.1 - 4.3e-251 835.4 36.9 5.4e-251 835.1 25.5 1.1 1 0 0 1 1 1 1 Nop14-like family G-patch PF01585.18 CCF32352.1 - 8.4e-08 31.8 4.5 1.6e-07 30.9 3.1 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 CCF32352.1 - 1.1 9.1 7.9 0.18 11.7 2.1 2.3 2 1 0 2 2 2 0 DExH-box splicing factor binding site Ank_2 PF12796.2 CCF32354.1 - 3.1e-26 91.5 1.2 7.8e-16 58.1 0.4 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 CCF32354.1 - 1.4e-17 62.4 0.4 5.3e-09 35.4 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 CCF32354.1 - 8.2e-17 61.2 0.3 6.9e-08 32.8 0.0 2.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF32354.1 - 1.9e-15 56.4 0.5 2.3e-07 30.8 0.1 3.1 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF32354.1 - 3.8e-13 48.2 0.1 0.00012 21.9 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Phe_tRNA-synt_N PF02912.13 CCF32354.1 - 0.0015 18.1 0.0 0.042 13.5 0.0 2.2 2 0 0 2 2 2 1 Aminoacyl tRNA synthetase class II, N-terminal domain TP6A_N PF04406.9 CCF32355.1 - 2.3e-20 72.0 0.1 3.7e-20 71.3 0.0 1.3 1 0 0 1 1 1 1 Type IIB DNA topoisomerase Prenyltrans PF00432.16 CCF32356.1 - 8.5e-24 82.8 13.6 1.1e-09 37.6 0.2 5.6 6 0 0 6 6 6 3 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 CCF32356.1 - 3.2e-21 75.8 2.8 4.1e-14 52.9 0.1 4.3 4 2 1 5 5 5 3 Prenyltransferase-like Prenyltrans_1 PF13243.1 CCF32356.1 - 7.9e-21 74.1 1.1 1.8e-10 40.8 0.1 5.1 4 2 2 6 6 6 3 Prenyltransferase-like Pec_lyase PF09492.5 CCF32356.1 - 0.00013 21.2 1.5 0.15 11.1 0.0 4.0 4 1 0 5 5 5 2 Pectic acid lyase Chromadorea_ALT PF05535.7 CCF32356.1 - 0.025 14.6 0.0 0.078 13.0 0.0 1.9 1 0 0 1 1 1 0 Chromadorea ALT protein SGS PF05002.10 CCF32357.1 - 2.8e-21 75.0 1.5 8e-21 73.5 1.0 1.9 1 0 0 1 1 1 1 SGS domain CS PF04969.11 CCF32357.1 - 7.6e-09 36.0 0.0 1.9e-08 34.6 0.0 1.8 1 1 0 1 1 1 1 CS domain TPR_11 PF13414.1 CCF32357.1 - 6.1e-07 28.9 1.8 1.4e-05 24.6 0.0 2.4 1 1 1 2 2 2 1 TPR repeat TPR_2 PF07719.12 CCF32357.1 - 0.00057 19.6 2.2 1.3 9.0 0.2 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 CCF32357.1 - 0.22 11.1 2.6 0.9 9.2 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4611 PF15387.1 CCF32357.1 - 0.29 11.2 3.1 0.3 11.2 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) PH_6 PF15406.1 CCF32358.1 - 3.5e-47 159.0 5.8 3.5e-47 159.0 4.0 2.4 2 1 1 3 3 3 1 Pleckstrin homology domain PH PF00169.24 CCF32358.1 - 0.004 17.3 0.0 0.0099 16.0 0.0 1.8 1 1 0 1 1 1 1 PH domain TPR_8 PF13181.1 CCF32360.1 - 3e-06 26.6 0.7 4.5 7.2 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.1 CCF32360.1 - 1.6e-05 24.3 2.9 0.32 10.8 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 CCF32360.1 - 0.0018 17.8 0.3 13 5.5 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat INT_SG_DDX_CT_C PF15300.1 CCF32360.1 - 0.015 14.7 0.0 0.044 13.2 0.0 1.8 1 0 0 1 1 1 0 INTS6/SAGE1/DDX26B/CT45 C-terminus TPR_16 PF13432.1 CCF32360.1 - 0.016 15.8 6.9 0.97 10.1 0.4 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 CCF32360.1 - 0.022 15.3 7.1 12 6.8 0.0 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.9 CCF32360.1 - 0.039 14.3 0.0 0.56 10.8 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 CCF32360.1 - 0.041 13.8 4.3 14 5.8 0.0 4.6 4 1 0 4 4 4 0 Tetratricopeptide repeat WD40 PF00400.27 CCF32361.1 - 2.7e-38 128.4 15.2 6.3e-10 38.5 0.0 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat Sof1 PF04158.9 CCF32361.1 - 3.3e-29 100.7 11.6 6.8e-29 99.7 8.1 1.5 1 0 0 1 1 1 1 Sof1-like domain BBS2_Mid PF14783.1 CCF32361.1 - 3.6e-05 23.5 0.0 9 6.1 0.0 4.5 3 2 2 5 5 5 3 Ciliary BBSome complex subunit 2, middle region Cytochrom_D1 PF02239.11 CCF32361.1 - 0.013 13.7 0.0 1.5 6.9 0.0 2.8 2 1 1 3 3 3 0 Cytochrome D1 heme domain DUF3312 PF11768.3 CCF32361.1 - 0.046 11.9 0.0 0.38 8.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3312) adh_short PF00106.20 CCF32362.1 - 1.5e-29 103.0 1.9 2.6e-29 102.2 1.3 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF32362.1 - 2.4e-11 43.8 0.0 3.2e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF32362.1 - 3.1e-11 43.2 4.2 1.8e-10 40.8 2.9 2.0 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF32362.1 - 0.016 14.6 0.3 0.027 13.9 0.2 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF32362.1 - 0.036 14.0 0.2 0.067 13.2 0.2 1.4 1 0 0 1 1 1 0 NADH(P)-binding GFA PF04828.9 CCF32363.1 - 2.4e-07 30.5 0.7 2.4e-07 30.5 0.5 1.6 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme A2L_zn_ribbon PF08792.5 CCF32363.1 - 0.12 11.9 0.1 0.12 11.9 0.1 2.5 3 0 0 3 3 3 0 A2L zinc ribbon domain Cys_rich_CWC PF14375.1 CCF32363.1 - 0.17 11.7 2.2 0.28 11.1 0.3 2.0 2 0 0 2 2 2 0 Cysteine-rich CWC Auto_anti-p27 PF06677.7 CCF32363.1 - 0.67 9.7 0.1 0.67 9.7 0.1 2.6 2 1 1 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) MFS_1 PF07690.11 CCF32364.1 - 2e-37 128.7 39.2 2e-37 128.7 27.2 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF32364.1 - 3.1e-13 49.1 13.3 3.1e-13 49.1 9.2 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter Pkinase PF00069.20 CCF32365.1 - 4.1e-48 163.7 0.1 6.6e-48 163.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF32365.1 - 1.1e-29 103.2 0.0 1.7e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1777 PF08648.7 CCF32365.1 - 0.00012 21.9 32.3 0.00012 21.9 22.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1777) Kinase-like PF14531.1 CCF32365.1 - 0.00037 19.5 0.1 0.001 18.0 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 CCF32365.1 - 0.002 17.2 0.0 0.002 17.2 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family PIP49_C PF12260.3 CCF32365.1 - 0.13 11.7 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 CDC45 PF02724.9 CCF32365.1 - 3 5.7 13.8 6 4.7 9.5 1.4 1 0 0 1 1 1 0 CDC45-like protein Glycogen_syn PF05693.8 CCF32366.1 - 0 1144.9 0.0 0 1144.6 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_5 PF08323.6 CCF32366.1 - 6e-06 25.9 0.1 1.1e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.15 CCF32366.1 - 1.1e-05 24.8 0.0 0.017 14.5 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 CCF32366.1 - 3e-05 24.2 0.1 6.9e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain F-box-like PF12937.2 CCF32367.1 - 1.8e-09 37.1 1.0 5.8e-09 35.5 0.7 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF32367.1 - 0.0058 16.2 6.5 0.0074 15.9 1.2 3.1 2 1 0 2 2 2 1 F-box domain adh_short PF00106.20 CCF32369.1 - 2.4e-21 76.3 0.1 3.9e-21 75.6 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF32369.1 - 2.6e-12 47.0 0.2 3.2e-12 46.7 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.5 CCF32369.1 - 3.8e-05 22.9 0.0 9e-05 21.7 0.0 1.6 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) KR PF08659.5 CCF32369.1 - 0.00014 21.6 0.0 0.0003 20.5 0.0 1.6 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF32369.1 - 0.0034 17.4 0.1 0.0076 16.2 0.0 1.7 1 1 0 1 1 1 1 NADH(P)-binding ubiquitin PF00240.18 CCF32369.1 - 0.06 12.7 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family NACHT PF05729.7 CCF32370.1 - 2.7e-06 27.1 0.0 9e-06 25.4 0.0 1.9 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.17 CCF32370.1 - 3.4e-06 26.1 0.1 1.5e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 NB-ARC domain AAA_22 PF13401.1 CCF32370.1 - 1e-05 25.6 0.0 5e-05 23.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CCF32370.1 - 0.0003 20.8 0.1 0.0013 18.7 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.12 CCF32370.1 - 0.042 13.2 0.0 0.094 12.1 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein PRK PF00485.13 CCF32370.1 - 0.07 12.6 0.0 7.6 6.0 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family FtsK_SpoIIIE PF01580.13 CCF32370.1 - 0.092 12.2 0.1 0.37 10.2 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family Ank_2 PF12796.2 CCF32371.1 - 1.1e-32 112.1 2.2 2e-12 47.2 0.0 7.7 6 3 1 7 7 7 5 Ankyrin repeats (3 copies) Ank PF00023.25 CCF32371.1 - 1.9e-17 62.1 18.1 7.3e-06 25.5 0.0 11.4 12 1 0 12 12 12 3 Ankyrin repeat Ank_4 PF13637.1 CCF32371.1 - 1.1e-16 60.8 8.7 5.3e-07 29.9 0.0 8.7 7 2 2 9 9 9 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF32371.1 - 1.3e-10 40.4 17.6 0.015 15.5 0.0 12.3 17 0 0 17 17 17 2 Ankyrin repeat Ank_5 PF13857.1 CCF32371.1 - 1e-08 35.1 12.9 0.0055 16.9 0.0 9.3 7 3 3 10 10 10 3 Ankyrin repeats (many copies) ketoacyl-synt PF00109.21 CCF32372.1 - 5.9e-71 238.9 0.2 1.5e-70 237.6 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 CCF32372.1 - 2.4e-35 120.9 0.1 5.4e-35 119.8 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.16 CCF32372.1 - 1.8e-26 93.2 0.0 1.5e-23 83.6 0.0 2.5 2 0 0 2 2 2 2 Acyl transferase domain PS-DH PF14765.1 CCF32372.1 - 2.6e-22 79.3 0.0 6.5e-22 78.0 0.0 1.7 2 0 0 2 2 2 1 Polyketide synthase dehydratase PP-binding PF00550.20 CCF32372.1 - 2.8e-09 37.0 0.6 6.8e-09 35.8 0.4 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.18 CCF32372.1 - 1.6e-05 24.0 0.0 3.7e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain NAD_binding_4 PF07993.7 CCF32373.1 - 2e-23 82.6 0.0 3e-23 82.0 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.16 CCF32373.1 - 3.1e-10 39.8 0.0 2e-09 37.2 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.20 CCF32373.1 - 0.00014 22.0 0.2 0.00079 19.6 0.1 2.2 1 1 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding PF00501.23 CCF32373.1 - 0.0007 18.0 0.0 0.0013 17.2 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme adh_short PF00106.20 CCF32373.1 - 0.0035 17.2 0.1 0.0035 17.2 0.1 2.8 2 1 0 2 2 2 1 short chain dehydrogenase Glyco_hydro_3_C PF01915.17 CCF32373.1 - 0.02 14.3 0.6 0.12 11.8 0.1 2.2 2 1 0 2 2 2 0 Glycosyl hydrolase family 3 C-terminal domain Polysacc_synt_2 PF02719.10 CCF32373.1 - 0.04 12.8 0.0 0.76 8.6 0.0 2.3 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein KR PF08659.5 CCF32373.1 - 0.045 13.4 0.0 0.15 11.7 0.0 1.9 2 0 0 2 2 2 0 KR domain DUF192 PF02643.10 CCF32374.1 - 0.038 13.6 0.0 0.069 12.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized ACR, COG1430 DUF3741 PF12552.3 CCF32374.1 - 0.12 12.0 0.1 2.9 7.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3741) Methyltransf_6 PF03737.10 CCF32375.1 - 6.6e-17 61.7 0.6 8.8e-17 61.3 0.4 1.1 1 0 0 1 1 1 1 Demethylmenaquinone methyltransferase Glyco_hydro_2_N PF02837.13 CCF32377.1 - 2.1e-29 102.2 0.3 7.8e-29 100.3 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.12 CCF32377.1 - 6.1e-14 51.6 0.1 1.8e-13 50.0 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.16 CCF32377.1 - 1.2e-08 35.3 0.0 2.6e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 SnoaL PF07366.7 CCF32378.1 - 5.2e-13 48.6 0.0 1.2e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.2 CCF32378.1 - 0.00012 22.4 0.3 0.00045 20.5 0.0 2.0 2 1 0 2 2 2 1 SnoaL-like domain zf-CCCH_2 PF14608.1 CCF32380.1 - 0.026 14.5 0.3 0.026 14.5 0.2 2.4 2 1 1 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type HA2 PF04408.18 CCF32381.1 - 4.2e-17 62.0 1.0 8.3e-17 61.0 0.0 2.1 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.26 CCF32381.1 - 4.2e-12 45.7 0.1 1.1e-11 44.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 CCF32381.1 - 1.2e-09 37.8 0.1 2.7e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 CCF32381.1 - 1.7e-08 34.7 0.1 6.3e-08 32.8 0.1 2.0 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 CCF32381.1 - 0.0021 18.3 0.5 0.008 16.4 0.0 2.2 2 0 0 2 2 2 1 ABC transporter AAA_29 PF13555.1 CCF32381.1 - 0.0029 17.1 0.0 0.0069 15.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 CCF32381.1 - 0.067 12.3 0.0 0.2 10.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function, DUF258 KaiC PF06745.8 CCF32381.1 - 0.081 12.0 0.0 0.18 10.9 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_23 PF13476.1 CCF32381.1 - 1.1 9.5 0.0 1.1 9.5 0.0 2.9 4 0 0 4 4 4 0 AAA domain RRM_6 PF14259.1 CCF32382.1 - 3.3e-44 148.7 0.0 1.2e-14 53.9 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CCF32382.1 - 5.5e-42 141.2 0.0 1.5e-12 46.9 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF32382.1 - 3.7e-23 81.1 0.0 1.9e-10 40.4 0.0 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CCF32382.1 - 1.2e-10 40.9 0.0 0.00037 20.2 0.0 3.9 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.8 CCF32382.1 - 2.5e-05 23.9 0.0 0.042 13.5 0.0 3.4 3 1 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Gly_transf_sug PF04488.10 CCF32384.1 - 1.8e-05 25.0 0.0 3.5e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 CCF32384.1 - 0.0069 14.9 0.1 0.033 12.6 0.0 1.8 1 1 1 2 2 2 1 TcdA/TcdB catalytic glycosyltransferase domain PCI PF01399.22 CCF32386.1 - 7.9e-21 74.3 0.1 2.3e-20 72.8 0.1 1.8 1 0 0 1 1 1 1 PCI domain PCI_Csn8 PF10075.4 CCF32386.1 - 0.024 14.4 0.0 0.085 12.6 0.0 1.9 1 0 0 1 1 1 0 COP9 signalosome, subunit CSN8 CLTH PF10607.4 CCF32386.1 - 1.1 8.9 6.1 4.4 6.9 2.1 3.0 2 1 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain FSH1 PF03959.8 CCF32387.1 - 6.5e-25 87.8 0.0 7.3e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.2 CCF32387.1 - 0.0001 22.2 0.0 0.00016 21.6 0.0 1.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF32387.1 - 0.017 14.8 0.0 0.02 14.6 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family GRIP PF01465.15 CCF32388.1 - 4.4e-17 61.3 0.0 9.2e-17 60.2 0.0 1.6 1 0 0 1 1 1 1 GRIP domain CENP-F_leu_zip PF10473.4 CCF32388.1 - 0.00025 20.8 43.0 0.034 14.0 13.8 3.3 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Baculo_PEP_C PF04513.7 CCF32388.1 - 0.00045 20.0 4.6 0.6 9.9 0.8 3.2 1 1 2 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_13 PF13166.1 CCF32388.1 - 0.00059 18.4 19.1 0.00078 18.0 13.2 1.1 1 0 0 1 1 1 1 AAA domain Filament PF00038.16 CCF32388.1 - 0.0017 17.9 36.9 0.037 13.5 12.5 3.0 1 1 2 3 3 3 2 Intermediate filament protein DUF3584 PF12128.3 CCF32388.1 - 0.002 15.5 33.3 0.003 14.9 20.9 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3584) Myosin_tail_1 PF01576.14 CCF32388.1 - 0.0041 14.9 40.4 0.0054 14.5 28.0 1.2 1 0 0 1 1 1 1 Myosin tail Laminin_I PF06008.9 CCF32388.1 - 0.0067 15.7 28.6 0.015 14.6 19.8 1.7 1 1 0 1 1 1 1 Laminin Domain I IncA PF04156.9 CCF32388.1 - 0.0085 15.7 42.9 0.041 13.4 17.4 2.4 1 1 1 2 2 2 1 IncA protein IFT57 PF10498.4 CCF32388.1 - 0.018 13.7 25.3 0.59 8.8 11.8 2.4 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 GAS PF13851.1 CCF32388.1 - 0.024 13.8 34.9 0.047 12.8 7.1 3.2 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding LXG PF04740.7 CCF32388.1 - 0.028 14.2 18.0 0.3 10.8 4.3 2.5 1 1 1 2 2 2 0 LXG domain of WXG superfamily Reo_sigmaC PF04582.7 CCF32388.1 - 0.031 13.4 8.0 0.042 13.0 1.4 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein NPV_P10 PF05531.7 CCF32388.1 - 0.072 13.3 7.6 0.41 10.9 0.3 3.7 1 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein FH2 PF02181.18 CCF32388.1 - 0.11 11.3 22.4 0.012 14.4 6.3 2.7 1 1 2 3 3 3 0 Formin Homology 2 Domain Bacillus_HBL PF05791.6 CCF32388.1 - 0.12 11.7 11.5 1 8.6 0.8 3.3 1 1 2 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) TBPIP PF07106.8 CCF32388.1 - 0.16 11.5 29.5 0.45 10.0 4.6 3.3 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) FlaC_arch PF05377.6 CCF32388.1 - 0.3 11.0 17.8 1.2 9.0 0.8 4.5 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) ALIX_LYPXL_bnd PF13949.1 CCF32388.1 - 0.31 9.9 32.5 0.25 10.2 2.2 2.6 1 1 1 2 2 2 0 ALIX V-shaped domain binding to HIV Spc7 PF08317.6 CCF32388.1 - 0.78 8.3 31.8 0.21 10.2 11.9 2.6 1 1 2 3 3 3 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.7 CCF32388.1 - 0.8 9.4 36.7 5.8 6.6 5.2 3.1 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein DUF948 PF06103.6 CCF32388.1 - 0.86 9.5 8.9 6.5 6.6 0.9 3.4 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.7 CCF32388.1 - 0.88 9.3 18.3 4.8 7.0 2.3 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) TMF_DNA_bd PF12329.3 CCF32388.1 - 0.94 9.3 39.5 0.81 9.5 6.2 3.8 1 1 3 4 4 4 0 TATA element modulatory factor 1 DNA binding Lectin_N PF03954.9 CCF32388.1 - 1 8.7 12.9 0.85 9.0 1.9 3.0 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain EzrA PF06160.7 CCF32388.1 - 1 7.4 28.2 3.2 5.8 18.1 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA DUF745 PF05335.8 CCF32388.1 - 1.5 8.2 21.9 0.19 11.2 6.5 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF745) BLOC1_2 PF10046.4 CCF32388.1 - 1.7 8.8 16.9 3.6 7.7 2.1 3.7 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fib_alpha PF08702.5 CCF32388.1 - 2.1 8.4 17.0 7.3 6.7 4.5 2.6 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Sigma70_ner PF04546.8 CCF32388.1 - 2.3 7.7 26.6 0.63 9.6 2.7 2.2 1 1 1 2 2 2 0 Sigma-70, non-essential region Seryl_tRNA_N PF02403.17 CCF32388.1 - 2.7 8.0 36.0 1 9.4 9.6 3.4 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Tropomyosin_1 PF12718.2 CCF32388.1 - 2.8 7.7 42.2 18 5.1 17.5 2.9 1 1 0 2 2 2 0 Tropomyosin like Syntaxin-6_N PF09177.6 CCF32388.1 - 2.8 8.3 27.4 2.2 8.7 3.0 3.2 2 1 1 3 3 3 0 Syntaxin 6, N-terminal Prefoldin_2 PF01920.15 CCF32388.1 - 3.3 7.4 34.8 1.9 8.2 1.6 4.9 2 1 2 4 4 4 0 Prefoldin subunit CALCOCO1 PF07888.6 CCF32388.1 - 3.5 5.7 34.9 0.074 11.3 5.9 2.7 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF972 PF06156.8 CCF32388.1 - 3.7 7.9 27.9 12 6.2 2.5 4.0 1 1 3 4 4 4 0 Protein of unknown function (DUF972) Lebercilin PF15619.1 CCF32388.1 - 4.5 6.6 39.6 20 4.5 1.3 2.3 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DivIC PF04977.10 CCF32388.1 - 4.8 6.7 31.3 0.57 9.7 5.8 4.3 1 1 2 4 4 4 0 Septum formation initiator TMPIT PF07851.8 CCF32388.1 - 8.1 5.4 20.2 0.26 10.3 6.1 2.2 1 1 1 2 2 2 0 TMPIT-like protein AATF-Che1 PF13339.1 CCF32388.1 - 8.2 6.5 28.9 3.7 7.7 7.9 2.5 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor Tnp_P_element PF12017.3 CCF32388.1 - 8.7 5.4 17.3 2.6 7.2 1.2 3.1 2 1 1 3 3 3 0 Transposase protein adh_short PF00106.20 CCF32389.1 - 3.3e-21 75.9 3.8 2.4e-20 73.1 2.6 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF32389.1 - 1.7e-17 64.0 2.5 3e-16 59.9 1.7 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF32389.1 - 3.9e-08 33.1 1.8 1e-07 31.7 0.3 2.0 2 0 0 2 2 2 1 KR domain ADH_zinc_N PF00107.21 CCF32389.1 - 0.00016 21.2 0.1 0.00034 20.1 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Shikimate_DH PF01488.15 CCF32389.1 - 0.0019 18.3 0.6 0.0045 17.1 0.4 1.7 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.16 CCF32389.1 - 0.003 17.0 0.7 0.056 12.8 0.5 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.12 CCF32389.1 - 0.0032 17.8 0.4 0.0076 16.6 0.3 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_10 PF13460.1 CCF32389.1 - 0.0077 16.2 0.3 0.026 14.5 0.1 2.0 2 0 0 2 2 2 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 CCF32389.1 - 0.021 13.7 0.1 0.037 12.9 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NAD_binding_7 PF13241.1 CCF32389.1 - 0.033 14.4 0.1 0.085 13.1 0.1 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding AdoHcyase_NAD PF00670.16 CCF32389.1 - 0.059 13.2 1.2 0.11 12.3 0.9 1.6 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Pyr_redox PF00070.22 CCF32389.1 - 0.13 12.6 0.8 4.5 7.7 0.2 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 CCF32389.1 - 0.37 10.4 2.7 2.5 7.7 0.7 2.6 2 1 1 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Dynamin_N PF00350.18 CCF32390.1 - 1.1e-22 80.6 0.0 2.2e-22 79.6 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 CCF32390.1 - 1.1e-12 47.3 0.0 1.1e-08 34.2 0.0 2.3 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.18 CCF32390.1 - 1.3e-05 25.0 0.0 5e-05 23.2 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.1 CCF32390.1 - 0.0064 15.9 0.1 0.02 14.3 0.0 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.1 CCF32390.1 - 0.0067 16.7 0.0 0.38 11.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain GED PF02212.13 CCF32390.1 - 0.039 13.8 0.2 0.15 12.0 0.1 1.9 2 0 0 2 2 2 0 Dynamin GTPase effector domain Miro PF08477.8 CCF32390.1 - 0.044 14.2 0.0 0.1 13.0 0.0 1.7 1 1 0 1 1 1 0 Miro-like protein AAA_21 PF13304.1 CCF32390.1 - 0.051 13.5 0.0 0.077 12.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF3342 PF11822.3 CCF32390.1 - 0.3 10.1 0.1 0.88 8.6 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) Peptidase_S10 PF00450.17 CCF32391.1 - 5.3e-07 29.1 0.0 6.4e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase DUF676 PF05057.9 CCF32392.1 - 3.6e-51 173.5 0.0 5.3e-51 172.9 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.2 CCF32392.1 - 4.9e-06 26.5 0.1 9.8e-06 25.6 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF32392.1 - 9.2e-06 25.4 0.0 1.6e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 CCF32392.1 - 0.00026 20.6 0.0 0.00049 19.7 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.20 CCF32392.1 - 0.032 13.8 0.0 0.059 12.9 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Chromate_transp PF02417.10 CCF32392.1 - 0.066 12.8 0.6 0.14 11.7 0.4 1.5 1 0 0 1 1 1 0 Chromate transporter Dispanin PF04505.7 CCF32392.1 - 0.12 11.9 0.2 0.25 10.9 0.1 1.4 1 0 0 1 1 1 0 Interferon-induced transmembrane protein RNase_T PF00929.19 CCF32393.1 - 2.2e-08 34.5 0.0 0.0054 17.0 0.0 2.4 2 0 0 2 2 2 2 Exonuclease Oligomerisation PF02410.10 CCF32394.1 - 1.2e-06 28.4 0.0 0.0066 16.4 0.0 2.9 3 0 0 3 3 3 2 Oligomerisation domain RNA_pol PF00940.14 CCF32395.1 - 4.9e-162 539.0 0.0 7.6e-162 538.4 0.0 1.3 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.1 CCF32395.1 - 1.8e-77 260.7 0.9 4.9e-77 259.3 0.8 1.6 2 0 0 2 2 2 1 DNA-directed RNA polymerase N-terminal DHHA2 PF02833.9 CCF32396.1 - 8.5e-15 55.0 0.0 9.4e-15 54.9 0.0 1.0 1 0 0 1 1 1 1 DHHA2 domain DUF1168 PF06658.7 CCF32397.1 - 3 7.3 10.9 3.7 7.0 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1168) Seipin PF06775.9 CCF32398.1 - 5.2e-35 120.7 0.0 6.3e-35 120.4 0.0 1.1 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) FCH PF00611.18 CCF32399.1 - 7.2e-21 74.1 0.1 2.1e-20 72.6 0.0 1.9 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Not1 PF04054.10 CCF32400.1 - 1.1e-106 356.8 0.0 4.1e-106 355.0 0.0 1.9 2 0 0 2 2 2 1 CCR4-Not complex component, Not1 DUF3819 PF12842.2 CCF32400.1 - 8.2e-49 165.0 1.6 8.2e-49 165.0 1.1 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3819) FKBP_C PF00254.23 CCF32401.1 - 8.6e-33 112.2 0.0 1.3e-32 111.6 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Cytomega_UL20A PF05984.7 CCF32401.1 - 0.0059 16.7 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Cytomegalovirus UL20A protein Pkinase PF00069.20 CCF32402.1 - 1.5e-29 102.9 0.0 2.7e-29 102.0 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF32402.1 - 1e-05 24.7 0.0 0.003 16.6 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase AhpC-TSA PF00578.16 CCF32407.1 - 4.2e-25 87.8 0.0 7e-25 87.1 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 CCF32407.1 - 8.8e-15 54.5 0.1 1.4e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.1 CCF32407.1 - 0.00015 21.6 0.0 0.00082 19.2 0.0 2.0 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme HMG14_17 PF01101.13 CCF32407.1 - 0.48 11.1 21.6 3.4 8.4 7.0 2.4 2 0 0 2 2 2 0 HMG14 and HMG17 Mito_carr PF00153.22 CCF32408.1 - 6.6e-70 230.9 0.0 2.9e-23 81.4 0.0 3.3 2 1 1 3 3 3 3 Mitochondrial carrier protein SIT PF15330.1 CCF32410.1 - 0.011 15.8 0.0 0.014 15.5 0.0 1.4 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Tyrosinase PF00264.15 CCF32411.1 - 1.4e-42 146.3 0.0 1.8e-42 146.0 0.0 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase Glyco_tranf_2_2 PF10111.4 CCF32412.1 - 0.027 13.5 0.0 0.04 13.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 DUF1541 PF07563.6 CCF32412.1 - 0.12 12.0 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1541) VacA2 PF03077.9 CCF32412.1 - 0.13 11.9 0.1 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Putative vacuolating cytotoxin PMI_typeI PF01238.16 CCF32413.1 - 3.1e-22 79.0 0.0 3.6e-22 78.8 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.6 CCF32413.1 - 1.5e-07 30.7 0.1 0.0013 18.2 0.1 2.3 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.14 CCF32413.1 - 5.4e-05 22.8 0.0 0.0042 16.7 0.0 2.2 2 0 0 2 2 2 2 AraC-like ligand binding domain Cupin_3 PF05899.7 CCF32413.1 - 0.00021 20.6 0.1 0.015 14.6 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF861) Cupin_4 PF08007.7 CCF32413.1 - 0.072 12.3 0.0 0.081 12.1 0.0 1.1 1 0 0 1 1 1 0 Cupin superfamily protein Ank_2 PF12796.2 CCF32414.1 - 5.4e-24 84.3 0.4 5.5e-08 33.0 0.0 5.0 4 1 0 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 CCF32414.1 - 9.1e-24 82.0 7.6 1.2e-06 28.0 0.1 6.7 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.1 CCF32414.1 - 2.4e-18 64.3 9.1 0.0036 17.4 0.0 8.7 9 0 0 9 9 9 5 Ankyrin repeat Ank_4 PF13637.1 CCF32414.1 - 1.4e-16 60.4 1.2 6.6e-07 29.6 0.0 6.3 6 1 1 7 7 7 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF32414.1 - 2.1e-12 46.8 14.6 0.00043 20.4 0.0 7.6 7 0 0 7 7 7 3 Ankyrin repeats (many copies) Glyoxalase_4 PF13669.1 CCF32414.1 - 0.11 12.4 0.1 0.72 9.8 0.0 2.2 2 0 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily GLTP PF08718.6 CCF32415.1 - 5.4e-48 162.8 0.0 7.6e-48 162.3 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) MatE PF01554.13 CCF32417.1 - 6.6e-33 113.6 24.3 2.4e-23 82.5 5.0 2.3 2 0 0 2 2 2 2 MatE Sod_Cu PF00080.15 CCF32418.1 - 6.3e-15 55.5 0.0 7.9e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) ADK_lid PF05191.9 CCF32418.1 - 0.13 11.9 0.1 0.29 10.8 0.1 1.6 1 0 0 1 1 1 0 Adenylate kinase, active site lid Sdh_cyt PF01127.17 CCF32420.1 - 9.2e-07 28.7 0.2 1.2e-06 28.4 0.1 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit PLU-1 PF08429.6 CCF32421.1 - 5.2e-99 331.3 15.9 9.1e-97 323.9 10.3 2.2 2 0 0 2 2 2 2 PLU-1-like protein JmjC PF02373.17 CCF32421.1 - 1.3e-42 144.5 0.1 3e-42 143.4 0.1 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase ARID PF01388.16 CCF32421.1 - 5.2e-26 90.3 0.0 1.8e-25 88.5 0.0 2.0 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain PHD PF00628.24 CCF32421.1 - 5.4e-16 58.0 43.3 9.9e-09 34.7 7.8 4.5 4 0 0 4 4 4 2 PHD-finger JmjN PF02375.12 CCF32421.1 - 1.5e-15 56.3 1.7 3.3e-15 55.2 1.2 1.6 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.11 CCF32421.1 - 9.6e-14 51.2 2.9 9.6e-14 51.2 2.0 2.0 2 0 0 2 2 2 1 C5HC2 zinc finger zf-PHD-like PF15446.1 CCF32421.1 - 0.02 14.1 13.1 0.019 14.2 2.3 2.6 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain zf-HC5HC2H PF13771.1 CCF32421.1 - 0.028 14.5 18.4 0.066 13.3 1.0 3.4 3 0 0 3 3 3 0 PHD-like zinc-binding domain zf-RING_2 PF13639.1 CCF32421.1 - 1.9 8.3 24.9 5.4 6.9 4.0 2.8 2 0 0 2 2 2 0 Ring finger domain DUF663 PF04950.7 CCF32423.1 - 1.9e-88 296.2 0.1 1.9e-88 296.2 0.1 1.9 2 0 0 2 2 1 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 CCF32423.1 - 4.8e-26 90.1 0.0 3.5e-25 87.3 0.0 2.4 2 0 0 2 2 2 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.22 CCF32423.1 - 6.2e-06 25.7 0.0 0.0023 17.3 0.0 2.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 CCF32423.1 - 1.7e-05 24.9 0.0 4.7e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF32423.1 - 1.8e-05 24.8 1.0 4.3e-05 23.5 0.0 2.2 3 0 0 3 3 1 1 AAA ATPase domain NACHT PF05729.7 CCF32423.1 - 0.00017 21.3 0.0 0.00042 20.0 0.0 1.8 1 1 0 1 1 1 1 NACHT domain AAA PF00004.24 CCF32423.1 - 0.00029 21.0 0.0 0.0009 19.4 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 CCF32423.1 - 0.00036 20.2 0.4 0.0016 18.1 0.0 2.1 2 0 0 2 2 2 1 Part of AAA domain AAA_25 PF13481.1 CCF32423.1 - 0.00066 19.1 0.0 0.0024 17.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 CCF32423.1 - 0.00067 19.6 0.0 0.0023 17.8 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.22 CCF32423.1 - 0.00074 19.8 2.1 0.0031 17.8 0.0 3.0 3 0 0 3 3 3 1 ABC transporter DUF258 PF03193.11 CCF32423.1 - 0.00091 18.4 0.0 0.056 12.6 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Miro PF08477.8 CCF32423.1 - 0.0011 19.4 0.0 0.0049 17.3 0.0 2.1 1 0 0 1 1 1 1 Miro-like protein AAA_33 PF13671.1 CCF32423.1 - 0.0013 18.6 0.7 0.0055 16.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 CCF32423.1 - 0.0013 19.5 0.0 0.0013 19.5 0.0 5.0 3 1 1 4 4 2 1 AAA domain PduV-EutP PF10662.4 CCF32423.1 - 0.0021 17.5 0.0 0.0073 15.7 0.0 1.8 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.1 CCF32423.1 - 0.0032 17.3 0.0 0.0088 15.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 CCF32423.1 - 0.0036 16.7 0.0 0.0098 15.3 0.0 1.7 2 0 0 2 2 2 1 AAA-like domain RNA_helicase PF00910.17 CCF32423.1 - 0.0052 16.9 0.0 0.014 15.5 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.1 CCF32423.1 - 0.0059 16.9 0.0 0.0059 16.9 0.0 4.6 4 2 1 5 5 3 1 AAA domain NTPase_1 PF03266.10 CCF32423.1 - 0.0096 15.6 0.2 0.024 14.3 0.1 1.7 1 0 0 1 1 1 1 NTPase cobW PF02492.14 CCF32423.1 - 0.011 15.2 0.0 0.03 13.7 0.0 1.7 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.9 CCF32423.1 - 0.011 15.4 0.2 0.011 15.4 0.1 2.4 2 1 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.1 CCF32423.1 - 0.027 14.0 0.1 0.027 14.0 0.0 2.6 3 0 0 3 3 2 0 AAA domain AAA_5 PF07728.9 CCF32423.1 - 0.049 13.3 1.1 0.17 11.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_21 PF13304.1 CCF32423.1 - 0.24 11.3 2.2 1.7 8.5 0.0 3.0 2 1 0 2 2 2 0 AAA domain WD40 PF00400.27 CCF32424.1 - 5e-19 67.3 1.6 7.6e-05 22.4 0.0 4.8 4 0 0 4 4 4 4 WD domain, G-beta repeat GMC_oxred_C PF05199.8 CCF32427.1 - 4.9e-17 62.5 0.0 5.3e-17 62.4 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase Epimerase PF01370.16 CCF32428.1 - 1.2e-17 64.1 0.0 2e-17 63.4 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 CCF32428.1 - 6.7e-11 41.5 0.1 4.7e-10 38.8 0.1 2.1 2 1 0 2 2 2 1 Male sterility protein 3Beta_HSD PF01073.14 CCF32428.1 - 1.9e-09 36.6 0.0 3.1e-09 35.9 0.0 1.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 CCF32428.1 - 7.7e-08 32.5 0.1 1.5e-07 31.6 0.1 1.5 1 1 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 CCF32428.1 - 6e-05 23.0 0.0 0.00024 21.0 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF32428.1 - 0.00067 19.3 0.0 0.0014 18.3 0.0 1.6 1 0 0 1 1 1 1 KR domain NmrA PF05368.8 CCF32428.1 - 0.0024 17.1 0.0 0.0081 15.4 0.0 1.8 2 0 0 2 2 2 1 NmrA-like family MFS_1 PF07690.11 CCF32429.1 - 8.2e-29 100.4 23.9 4e-28 98.1 17.3 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF4381 PF14316.1 CCF32429.1 - 0.0012 19.0 0.1 0.015 15.4 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4381) Aldedh PF00171.17 CCF32430.1 - 3.7e-127 424.4 0.0 4.3e-127 424.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 CCF32430.1 - 2.6e-05 23.5 0.0 4.1e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1487) Mhr1 PF12829.2 CCF32430.1 - 0.17 11.7 0.0 8.4 6.2 0.0 2.3 2 0 0 2 2 2 0 Transcriptional regulation of mitochondrial recombination Mito_carr PF00153.22 CCF32431.1 - 9.7e-30 102.1 0.3 1.8e-15 56.3 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Sugar_tr PF00083.19 CCF32432.1 - 3.3e-105 352.2 15.3 3.9e-105 352.0 10.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF32432.1 - 4.1e-29 101.4 45.9 7e-27 94.0 14.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CCF32432.1 - 9.2e-09 34.1 22.4 4.1e-06 25.4 2.2 3.0 3 0 0 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.2 CCF32432.1 - 0.00019 21.1 0.4 0.0013 18.4 0.1 2.5 2 0 0 2 2 2 1 MFS_1 like family Tmemb_18A PF09771.4 CCF32432.1 - 6.6 6.7 6.2 12 5.8 0.1 3.5 3 1 1 4 4 4 0 Transmembrane protein 188 Septin PF00735.13 CCF32433.1 - 1.3e-90 303.2 0.2 1.5e-90 303.0 0.1 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 CCF32433.1 - 9e-07 28.8 0.0 1.4e-06 28.2 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.11 CCF32433.1 - 1.5e-06 27.4 0.0 2.5e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.22 CCF32433.1 - 1e-05 25.1 0.4 0.00047 19.6 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 CCF32433.1 - 1.8e-05 23.9 0.0 3.1e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 CCF32433.1 - 0.00051 19.8 0.4 0.84 9.4 0.1 2.5 1 1 1 2 2 2 2 Dynamin family AAA_10 PF12846.2 CCF32433.1 - 0.0032 16.9 0.0 0.004 16.6 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain AAA_22 PF13401.1 CCF32433.1 - 0.0036 17.4 0.0 0.0067 16.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.22 CCF32433.1 - 0.0052 17.0 0.2 0.0082 16.4 0.1 1.6 1 1 0 1 1 1 1 ABC transporter Gtr1_RagA PF04670.7 CCF32433.1 - 0.0063 15.6 0.1 0.046 12.8 0.0 2.0 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region NB-ARC PF00931.17 CCF32433.1 - 0.01 14.6 0.0 0.017 14.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain T2SE PF00437.15 CCF32433.1 - 0.024 13.5 0.0 0.048 12.5 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.1 CCF32433.1 - 0.025 14.5 0.0 0.03 14.3 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.1 CCF32433.1 - 0.029 14.7 0.0 0.058 13.7 0.0 1.4 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 CCF32433.1 - 0.03 13.7 0.0 0.056 12.9 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Ras PF00071.17 CCF32433.1 - 0.051 12.9 0.0 0.18 11.2 0.0 1.9 2 1 0 2 2 2 0 Ras family AAA_29 PF13555.1 CCF32433.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.7 CCF32433.1 - 0.13 11.3 0.1 7.5 5.5 0.0 2.5 1 1 1 2 2 2 0 Zeta toxin Ribosomal_L32p PF01783.18 CCF32434.1 - 2.3e-13 50.0 6.7 3.4e-13 49.5 4.7 1.2 1 0 0 1 1 1 1 Ribosomal L32p protein family DUF3654 PF12376.3 CCF32434.1 - 0.082 12.7 0.4 0.097 12.4 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3654) Stc1 PF12898.2 CCF32434.1 - 0.32 11.1 3.4 0.45 10.6 2.3 1.2 1 0 0 1 1 1 0 Stc1 domain zf-ribbon_3 PF13248.1 CCF32434.1 - 0.43 9.8 5.4 0.78 9.0 3.7 1.4 1 0 0 1 1 1 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 CCF32434.1 - 6.7 6.7 6.9 3.3 7.7 0.8 2.2 1 1 1 2 2 2 0 Zinc ribbon domain WD40 PF00400.27 CCF32435.1 - 7.3e-22 76.3 16.2 5e-11 42.0 0.1 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat eIF2A PF08662.6 CCF32435.1 - 0.00077 19.2 0.3 0.0052 16.5 0.0 2.4 2 2 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.1 CCF32435.1 - 0.0027 16.8 0.1 0.46 9.5 0.0 2.9 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Lactonase PF10282.4 CCF32435.1 - 0.016 14.2 0.0 0.12 11.4 0.0 2.1 1 1 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Coatomer_WDAD PF04053.9 CCF32435.1 - 0.056 12.2 0.0 0.058 12.1 0.0 1.2 1 0 0 1 1 1 0 Coatomer WD associated region FG-GAP_2 PF14312.1 CCF32435.1 - 0.41 10.6 3.5 6.8 6.7 0.8 2.9 2 1 0 2 2 2 0 FG-GAP repeat DNA_pol_delta_4 PF04081.8 CCF32436.1 - 7.6e-30 103.7 0.6 1.1e-29 103.1 0.4 1.3 1 0 0 1 1 1 1 DNA polymerase delta, subunit 4 DUF2419 PF10343.4 CCF32437.1 - 6.8e-133 442.3 0.0 8.1e-133 442.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2419) DUF1563 PF07599.6 CCF32437.1 - 0.033 14.0 0.1 0.063 13.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1563) ThiF PF00899.16 CCF32438.1 - 2.9e-40 137.2 0.6 6.7e-40 136.0 0.1 1.9 2 0 0 2 2 2 1 ThiF family UBACT PF02134.16 CCF32438.1 - 1.1e-29 101.7 0.1 1.1e-29 101.7 0.1 2.5 3 0 0 3 3 2 1 Repeat in ubiquitin-activating (UBA) protein UAE_UbL PF14732.1 CCF32438.1 - 3.5e-23 81.4 1.2 2.8e-22 78.6 0.3 2.3 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.4 CCF32438.1 - 1.7e-18 65.7 1.1 1.7e-18 65.7 0.8 2.2 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.1 CCF32438.1 - 0.00082 19.5 0.1 0.0028 17.9 0.1 1.9 1 0 0 1 1 1 1 Putative NAD(P)-binding Pex14_N PF04695.8 CCF32438.1 - 0.011 15.7 6.3 0.029 14.4 4.4 1.7 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Shikimate_DH PF01488.15 CCF32438.1 - 0.015 15.4 0.0 0.037 14.1 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NotI PF12183.3 CCF32438.1 - 0.081 11.9 0.3 0.16 11.0 0.0 1.6 2 0 0 2 2 2 0 Restriction endonuclease NotI DUF2652 PF10851.3 CCF32438.1 - 0.085 12.8 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2652) DUF3753 PF12575.3 CCF32438.1 - 0.12 12.1 0.2 0.3 10.9 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) DASH_Dam1 PF08653.5 CCF32438.1 - 0.17 11.6 0.2 7 6.5 0.1 2.5 2 0 0 2 2 2 0 DASH complex subunit Dam1 PRCC PF10253.4 CCF32438.1 - 0.55 10.9 11.9 0.026 15.2 1.5 2.7 3 1 0 3 3 2 0 Mitotic checkpoint regulator, MAD2B-interacting adh_short PF00106.20 CCF32439.1 - 5.2e-21 75.2 4.9 2.4e-19 69.8 3.4 2.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF32439.1 - 5.2e-18 65.6 0.0 8.2e-18 65.0 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF32439.1 - 3.2e-07 30.1 0.4 1.6e-06 27.9 0.1 2.0 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.1 CCF32439.1 - 0.00074 19.5 0.1 0.0022 18.0 0.0 1.8 2 0 0 2 2 2 1 NADH(P)-binding Epimerase PF01370.16 CCF32439.1 - 0.0097 15.3 1.7 0.068 12.5 0.3 2.7 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.15 CCF32439.1 - 0.043 13.9 0.0 0.11 12.5 0.0 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 CCF32439.1 - 0.071 12.7 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1194 PF06707.6 CCF32439.1 - 0.073 12.0 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1194) ApbA PF02558.11 CCF32439.1 - 0.1 12.0 0.2 0.25 10.7 0.1 1.8 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA PAP2 PF01569.16 CCF32440.1 - 6.6e-17 61.3 4.0 6.6e-17 61.3 2.8 2.0 2 0 0 2 2 2 1 PAP2 superfamily zf-C3HC4_3 PF13920.1 CCF32441.1 - 1.3e-05 24.7 11.8 1.3e-05 24.7 8.2 2.5 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF32441.1 - 6.9e-05 22.4 9.7 6.9e-05 22.4 6.7 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CCF32441.1 - 0.00014 21.7 12.0 0.00014 21.7 8.3 2.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF32441.1 - 0.00016 21.4 10.7 0.00016 21.4 7.4 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.1 CCF32441.1 - 0.0073 16.0 3.6 0.018 14.7 2.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.2 CCF32441.1 - 8.2 6.6 9.9 1 9.5 3.7 1.8 2 0 0 2 2 2 0 RING-H2 zinc finger DnaJ PF00226.26 CCF32442.1 - 0.069 12.8 0.2 0.86 9.3 0.0 2.2 2 0 0 2 2 2 0 DnaJ domain zf-B_box PF00643.19 CCF32442.1 - 9.1 6.2 12.7 0.43 10.4 4.6 2.0 2 0 0 2 2 2 0 B-box zinc finger Fungal_trans PF04082.13 CCF32443.1 - 1.4e-17 63.4 0.5 5.1e-17 61.5 0.1 2.0 2 1 1 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF32443.1 - 5.5e-10 38.9 8.3 1.1e-09 38.0 5.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3373 PF11853.3 CCF32443.1 - 0.14 10.7 0.1 0.2 10.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) BTB PF00651.26 CCF32444.1 - 7.2e-08 32.4 0.0 1.6e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Glyco_transf_90 PF05686.7 CCF32447.1 - 2.4e-11 42.9 2.6 2.5e-10 39.6 1.5 2.5 2 1 0 2 2 2 1 Glycosyl transferase family 90 Pkinase PF00069.20 CCF32448.1 - 9.7e-59 198.6 0.0 1.3e-58 198.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF32448.1 - 8.6e-38 129.8 0.0 7.3e-37 126.8 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF32448.1 - 9.3e-05 21.5 0.0 0.00017 20.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like NCA2 PF08637.5 CCF32448.1 - 0.0029 16.5 0.0 0.0074 15.2 0.0 1.6 2 0 0 2 2 2 1 ATP synthase regulation protein NCA2 APH PF01636.18 CCF32448.1 - 0.029 14.0 0.0 0.11 12.2 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family BTB PF00651.26 CCF32449.1 - 4.4e-23 81.4 0.2 3.7e-13 49.4 0.3 2.6 2 0 0 2 2 2 2 BTB/POZ domain Ank_2 PF12796.2 CCF32449.1 - 3.1e-11 43.4 0.0 7e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 CCF32449.1 - 6e-11 41.5 0.6 2e-05 24.1 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 CCF32449.1 - 5.7e-09 36.2 0.0 1.5e-08 34.9 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF32449.1 - 2.5e-07 30.7 0.0 1.7e-06 28.0 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF32449.1 - 3.4e-07 29.8 0.1 0.026 14.7 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat SAICAR_synt PF01259.13 CCF32450.1 - 8.5e-88 293.6 0.0 1e-87 293.3 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase Asp PF00026.18 CCF32451.1 - 2.2e-63 214.4 2.2 2.7e-63 214.1 1.5 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CCF32451.1 - 9e-08 32.2 0.0 3.4e-07 30.3 0.0 2.0 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 CCF32451.1 - 0.0085 15.6 0.1 3.6 7.1 0.0 2.4 2 0 0 2 2 2 2 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 CCF32451.1 - 0.057 13.9 0.9 30 5.1 0.0 3.6 3 0 0 3 3 3 0 Aspartyl protease Transket_pyr PF02779.19 CCF32454.1 - 6.7e-58 195.1 0.0 1.1e-57 194.4 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 CCF32454.1 - 5.1e-50 169.8 0.0 7.4e-50 169.3 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component 2-oxoacid_dh PF00198.18 CCF32455.1 - 9e-75 250.8 0.1 1.3e-74 250.3 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 CCF32455.1 - 6.8e-19 67.2 5.0 1.1e-18 66.5 3.4 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme HlyD_2 PF12700.2 CCF32455.1 - 5.2e-07 29.1 7.3 3.6e-06 26.3 0.7 2.3 1 1 1 2 2 2 2 HlyD family secretion protein HlyD PF00529.15 CCF32455.1 - 0.00018 20.9 1.3 0.00018 20.9 0.9 2.1 2 0 0 2 2 2 1 HlyD family secretion protein Biotin_lipoyl_2 PF13533.1 CCF32455.1 - 0.00051 19.6 1.1 0.0029 17.2 0.1 2.3 1 1 1 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.1 CCF32455.1 - 0.0017 18.6 0.9 0.3 11.4 0.0 2.7 1 1 1 2 2 2 1 HlyD family secretion protein DUF2118 PF09891.4 CCF32455.1 - 0.0033 17.1 0.8 0.019 14.6 0.1 2.1 1 1 1 2 2 2 2 Uncharacterized protein conserved in archaea (DUF2118) GCV_H PF01597.14 CCF32455.1 - 0.0039 16.8 3.2 0.011 15.3 1.7 2.0 1 1 1 2 2 2 1 Glycine cleavage H-protein RnfC_N PF13375.1 CCF32455.1 - 0.0043 16.7 1.4 1.3 8.7 0.1 2.6 1 1 1 2 2 2 2 RnfC Barrel sandwich hybrid domain Trypan_PARP PF05887.6 CCF32455.1 - 0.024 14.4 19.3 0.043 13.6 13.4 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Neisseria_TspB PF05616.8 CCF32455.1 - 6.3 5.0 13.0 9.8 4.4 9.0 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Beta_helix PF13229.1 CCF32456.1 - 2.7e-14 53.2 11.2 7.7e-12 45.2 3.6 2.3 1 1 1 2 2 2 2 Right handed beta helix region Chondroitinas_B PF14592.1 CCF32456.1 - 1.9e-06 26.9 0.0 8.4e-06 24.8 0.0 2.0 2 0 0 2 2 2 1 Chondroitinase B DUF1565 PF07602.6 CCF32456.1 - 0.0033 16.5 1.8 0.028 13.5 0.1 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF1565) SGL PF08450.7 CCF32457.1 - 3.2e-25 88.9 1.6 7.4e-25 87.7 1.0 1.5 1 1 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Str_synth PF03088.11 CCF32457.1 - 4.8e-06 26.5 0.0 1.9e-05 24.5 0.0 1.9 1 1 0 1 1 1 1 Strictosidine synthase Arylesterase PF01731.15 CCF32457.1 - 0.0014 18.5 0.2 0.014 15.3 0.0 2.5 2 1 1 3 3 3 1 Arylesterase NHL PF01436.16 CCF32457.1 - 0.076 13.0 3.9 3 7.9 0.0 3.6 3 0 0 3 3 3 0 NHL repeat AAA_25 PF13481.1 CCF32458.1 - 8.7e-05 22.0 0.1 0.36 10.1 0.0 2.8 2 1 0 2 2 2 2 AAA domain KaiC PF06745.8 CCF32458.1 - 0.00041 19.5 0.1 0.00097 18.3 0.0 1.6 2 0 0 2 2 2 1 KaiC DnaB_C PF03796.10 CCF32458.1 - 0.0079 15.1 0.0 0.24 10.2 0.0 2.1 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain RecA PF00154.16 CCF32458.1 - 0.071 12.1 0.0 0.29 10.1 0.0 1.9 2 0 0 2 2 2 0 recA bacterial DNA recombination protein RXT2_N PF08595.6 CCF32458.1 - 3.5 7.3 5.4 2.1 8.1 0.1 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF4611 PF15387.1 CCF32458.1 - 4.1 7.6 8.9 5.5 7.2 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) UNC-93 PF05978.11 CCF32464.1 - 1.3e-08 34.4 7.9 1.3e-08 34.4 5.5 3.3 3 1 1 4 4 4 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.11 CCF32464.1 - 1.1e-06 27.6 44.6 1.1e-06 27.6 30.9 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF2761 PF10959.3 CCF32464.1 - 0.012 15.1 0.0 0.69 9.5 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2761) Pex14_N PF04695.8 CCF32465.1 - 2.9e-31 108.3 1.0 2.9e-31 108.3 0.7 3.9 2 2 1 3 3 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region zf-C4H2 PF10146.4 CCF32465.1 - 0.0012 18.9 3.5 0.0012 18.9 2.4 1.9 2 0 0 2 2 2 1 Zinc finger-containing protein CR6_interact PF10147.4 CCF32465.1 - 0.015 14.5 1.4 0.022 14.0 0.9 1.3 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 HLH PF00010.21 CCF32465.1 - 0.022 14.4 2.8 7.7 6.3 0.5 3.1 1 1 1 2 2 2 0 Helix-loop-helix DNA-binding domain Baculo_PEP_C PF04513.7 CCF32465.1 - 0.036 13.8 8.1 0.87 9.4 1.8 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus YPEB PF14620.1 CCF32465.1 - 0.041 12.9 2.7 0.063 12.2 1.9 1.3 1 0 0 1 1 1 0 YpeB sporulation DUF188 PF02639.9 CCF32465.1 - 0.075 12.4 1.3 1.1 8.7 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized BCR, YaiI/YqxD family COG1671 DUF244 PF03112.9 CCF32465.1 - 0.25 10.9 2.9 0.38 10.2 2.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein family (ORF7) DUF Orbi_VP5 PF00901.12 CCF32465.1 - 0.25 9.4 4.3 0.18 9.9 1.8 1.4 1 1 0 1 1 1 0 Orbivirus outer capsid protein VP5 DUF848 PF05852.6 CCF32465.1 - 0.92 9.3 9.7 1.7 8.4 6.7 1.4 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) DUF1664 PF07889.7 CCF32465.1 - 5.2 6.8 7.0 12 5.6 3.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) IncA PF04156.9 CCF32465.1 - 8.6 5.9 13.0 30 4.1 9.2 1.6 1 1 0 1 1 1 0 IncA protein Abhydrolase_3 PF07859.8 CCF32466.1 - 1.3e-42 145.7 0.0 3.6e-42 144.3 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF32466.1 - 3.2e-05 23.7 0.0 0.00015 21.5 0.0 1.9 1 1 1 2 2 2 1 Alpha/beta hydrolase family DUF2424 PF10340.4 CCF32466.1 - 5.1e-05 22.0 0.1 0.00022 20.0 0.1 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF2424) FAD_binding_4 PF01565.18 CCF32467.1 - 2.3e-16 59.5 0.0 4e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain ARPC4 PF05856.7 CCF32468.1 - 3.7e-75 250.9 2.9 4.3e-75 250.7 2.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) UCH PF00443.24 CCF32469.1 - 6.9e-52 176.2 0.0 9.2e-52 175.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CCF32469.1 - 1.1e-16 61.1 0.0 2.9e-16 59.7 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.18 CCF32469.1 - 4.8e-11 41.9 0.8 8.7e-10 37.8 0.1 2.4 2 0 0 2 2 2 1 Ubiquitin family Ubiquitin_2 PF14560.1 CCF32469.1 - 0.0072 16.5 0.1 0.086 13.1 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin-like domain DNA_gyraseB PF00204.20 CCF32469.1 - 0.15 11.2 2.1 2.1 7.5 0.0 2.6 2 1 0 2 2 2 0 DNA gyrase B His_Phos_1 PF00300.17 CCF32471.1 - 2.6e-31 108.8 0.0 3.1e-31 108.6 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Methyltransf_23 PF13489.1 CCF32472.1 - 8.8e-06 25.5 0.0 1.2e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF32472.1 - 0.0011 19.3 0.0 0.0021 18.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF32472.1 - 0.0027 18.2 0.0 0.0038 17.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF32472.1 - 0.0042 17.5 0.0 0.0084 16.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF32472.1 - 0.076 12.1 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Thiolase_N PF00108.18 CCF32473.1 - 4.7e-71 238.8 0.2 7.4e-71 238.2 0.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 CCF32473.1 - 2.6e-40 136.6 0.2 6e-40 135.4 0.1 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain Glyco_hydro_cc PF11790.3 CCF32474.1 - 1.1e-64 218.0 0.5 1.3e-64 217.8 0.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core EF1G PF00647.14 CCF32474.1 - 0.088 12.5 0.1 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 Elongation factor 1 gamma, conserved domain Fip1 PF05182.8 CCF32474.1 - 0.09 12.0 0.6 0.2 10.9 0.5 1.5 1 0 0 1 1 1 0 Fip1 motif Carb_anhydrase PF00194.16 CCF32475.1 - 3.7e-18 65.4 0.2 9.3e-18 64.1 0.1 1.6 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase DUF3548 PF12068.3 CCF32477.1 - 0.058 12.6 0.1 0.071 12.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3548) G-alpha PF00503.15 CCF32478.1 - 5.2e-117 390.8 0.3 6e-117 390.6 0.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 CCF32478.1 - 1.1e-13 50.7 0.6 2.4e-08 33.4 0.1 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CCF32478.1 - 0.001 18.2 0.9 0.12 11.4 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.1 CCF32478.1 - 0.057 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.1 CCF32478.1 - 0.059 12.7 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain CN_hydrolase PF00795.17 CCF32479.1 - 2.4e-30 105.2 0.0 3.2e-30 104.8 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Pectate_lyase_3 PF12708.2 CCF32480.1 - 5e-18 66.0 0.3 7e-18 65.5 0.2 1.2 1 0 0 1 1 1 1 Pectate lyase superfamily protein TPR_12 PF13424.1 CCF32482.1 - 1.8e-10 40.6 25.3 0.00046 20.0 0.4 8.2 8 1 1 9 9 9 4 Tetratricopeptide repeat AAA_16 PF13191.1 CCF32482.1 - 4e-08 33.4 0.1 1.7e-07 31.4 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 CCF32482.1 - 2.6e-06 27.6 0.0 2.3e-05 24.5 0.0 2.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 CCF32482.1 - 4.2e-06 26.5 0.0 1.5e-05 24.7 0.0 2.0 1 0 0 1 1 1 1 NACHT domain Arch_ATPase PF01637.13 CCF32482.1 - 2.3e-05 24.2 0.0 0.0001 22.0 0.0 2.2 2 0 0 2 2 2 1 Archaeal ATPase TPR_7 PF13176.1 CCF32482.1 - 0.00011 21.7 11.3 2.6 8.0 0.1 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.23 CCF32482.1 - 0.00051 19.5 2.4 21 4.9 0.0 5.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 CCF32482.1 - 0.019 15.5 8.1 52 4.8 0.0 7.2 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_2 PF07719.12 CCF32482.1 - 1.8 8.6 13.5 9.2 6.4 0.2 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.1 CCF32482.1 - 2 9.0 11.2 13 6.5 0.1 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Methyltransf_33 PF10017.4 CCF32483.1 - 3.5e-20 72.1 0.0 5e-20 71.6 0.0 1.3 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent Fungal_trans_2 PF11951.3 CCF32484.1 - 1.2e-25 89.9 1.3 1.2e-24 86.6 0.9 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain TFIIB PF00382.14 CCF32484.1 - 0.014 15.2 0.0 0.035 13.9 0.0 1.7 1 0 0 1 1 1 0 Transcription factor TFIIB repeat ELFV_dehydrog PF00208.16 CCF32485.1 - 1.7e-59 201.3 0.0 3e-59 200.5 0.0 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.7 CCF32485.1 - 7.6e-20 70.0 0.1 1.4e-14 52.6 0.0 2.7 2 1 1 3 3 3 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.13 CCF32485.1 - 0.0012 18.4 0.1 0.0047 16.5 0.0 1.9 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain DUF2937 PF11157.3 CCF32485.1 - 0.1 11.9 0.9 1 8.6 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) zf-HIT PF04438.11 CCF32487.1 - 2.5e-09 36.6 9.2 3.8e-09 36.0 6.3 1.3 1 0 0 1 1 1 1 HIT zinc finger DENN PF02141.16 CCF32488.1 - 5.5e-40 137.0 0.1 9.4e-40 136.3 0.0 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.13 CCF32488.1 - 1.1e-05 25.2 0.9 3.2e-05 23.8 0.0 2.4 3 0 0 3 3 3 1 uDENN domain DUF4113 PF13438.1 CCF32488.1 - 0.0054 16.3 0.2 1.5 8.5 0.0 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF4113) Elongin_A PF06881.6 CCF32488.1 - 0.012 15.9 5.7 0.012 15.9 4.0 2.3 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A PCRF PF03462.13 CCF32488.1 - 0.16 11.6 2.8 1.3 8.6 0.1 2.5 2 0 0 2 2 2 0 PCRF domain V_ATPase_I PF01496.14 CCF32488.1 - 1.5 6.6 8.2 2.1 6.1 5.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family zf-H2C2_2 PF13465.1 CCF32489.1 - 2.8e-07 30.4 7.8 1.3e-05 25.2 0.8 2.7 2 0 0 2 2 2 2 Zinc-finger double domain Fungal_trans PF04082.13 CCF32489.1 - 7.8e-07 28.2 5.4 5.2e-06 25.5 3.7 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2_4 PF13894.1 CCF32489.1 - 3.1e-05 23.9 14.2 0.0015 18.6 4.3 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.7 CCF32489.1 - 0.0015 18.6 3.8 0.0031 17.6 2.6 1.5 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 CCF32489.1 - 0.018 15.3 16.8 0.052 13.9 4.7 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 CCF32489.1 - 0.64 10.2 3.6 8.1 6.7 0.5 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.10 CCF32489.1 - 1.7 8.4 7.2 0.79 9.5 0.7 2.4 2 0 0 2 2 2 0 BED zinc finger DUF945 PF06097.6 CCF32490.1 - 0.14 10.8 0.0 0.17 10.6 0.0 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) Nucleoporin_C PF03177.9 CCF32492.1 - 1.3e-133 446.6 6.5 1.7e-133 446.2 4.5 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.6 CCF32492.1 - 6.8e-85 285.3 0.0 9.3e-85 284.9 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Phasin_2 PF09361.5 CCF32492.1 - 0.019 14.9 0.5 0.056 13.4 0.2 2.0 2 0 0 2 2 2 0 Phasin protein YihI PF04220.7 CCF32492.1 - 0.27 10.5 0.6 0.49 9.7 0.4 1.3 1 0 0 1 1 1 0 Der GTPase activator (YihI) adh_short PF00106.20 CCF32493.1 - 3.8e-23 82.2 0.0 5.2e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF32493.1 - 7.3e-14 52.1 0.0 1e-13 51.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF32493.1 - 6.2e-07 29.2 0.0 1.5e-06 28.0 0.0 1.6 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF32493.1 - 0.0029 17.6 0.0 0.0061 16.5 0.0 1.5 1 1 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 CCF32493.1 - 0.0077 15.1 0.0 0.01 14.7 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.15 CCF32493.1 - 0.015 15.3 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 CCF32493.1 - 0.17 11.5 0.4 0.26 10.9 0.0 1.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Erg28 PF03694.8 CCF32494.1 - 3.6e-39 133.2 0.2 4.7e-39 132.8 0.2 1.1 1 0 0 1 1 1 1 Erg28 like protein GalP_UDP_tr_C PF02744.12 CCF32495.1 - 2.3e-54 183.4 0.1 2.6e-54 183.2 0.1 1.0 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain HIT PF01230.18 CCF32495.1 - 1.7e-06 28.4 0.2 2.5e-06 27.9 0.1 1.3 1 1 0 1 1 1 1 HIT domain DcpS_C PF11969.3 CCF32495.1 - 0.11 12.6 0.3 0.25 11.5 0.2 1.6 1 1 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding Sugar_tr PF00083.19 CCF32497.1 - 6.4e-107 357.9 23.2 7.7e-107 357.6 16.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF32497.1 - 8.5e-21 74.0 28.0 4.6e-15 55.1 1.9 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF1228 PF06779.9 CCF32497.1 - 0.043 13.8 7.6 0.29 11.1 0.5 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1228) Fungal_trans PF04082.13 CCF32498.1 - 5.7e-16 58.1 2.6 1.8e-15 56.4 1.5 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zip PF02535.17 CCF32498.1 - 2.6 6.9 7.8 2.9 6.7 0.1 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter FAD_binding_3 PF01494.14 CCF32499.1 - 2.3e-79 267.0 0.0 2.9e-79 266.6 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF32499.1 - 3.2e-06 26.3 0.2 1.8e-05 23.8 0.0 2.2 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF32499.1 - 2.4e-05 24.2 0.0 9.5e-05 22.3 0.0 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.2 CCF32499.1 - 5.1e-05 22.5 0.0 0.00069 18.8 0.0 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 CCF32499.1 - 0.0014 17.7 0.0 0.0027 16.8 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.22 CCF32499.1 - 0.0028 18.0 0.0 0.084 13.2 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF32499.1 - 0.0079 15.0 0.0 0.014 14.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 CCF32499.1 - 0.011 14.2 0.0 0.016 13.6 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_2 PF07992.9 CCF32499.1 - 0.012 15.4 0.1 0.086 12.7 0.1 2.4 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF32499.1 - 0.043 12.4 0.0 0.11 11.1 0.0 1.6 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox_3 PF13738.1 CCF32499.1 - 0.076 13.0 0.0 0.26 11.3 0.0 1.9 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 CCF32499.1 - 0.11 12.5 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GIDA PF01134.17 CCF32499.1 - 0.18 10.6 0.0 0.32 9.7 0.0 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A Amidohydro_1 PF01979.15 CCF32500.1 - 1.7e-29 103.5 0.2 2e-29 103.3 0.2 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 CCF32500.1 - 1.4e-14 54.8 0.4 7.7e-12 45.8 0.3 2.8 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 CCF32500.1 - 2.1e-09 37.1 5.4 8.5e-08 31.8 0.3 2.5 1 1 0 2 2 2 2 Amidohydrolase family Amidohydro_5 PF13594.1 CCF32500.1 - 6.7e-07 29.0 0.2 2.8e-06 27.0 0.1 2.2 2 0 0 2 2 2 1 Amidohydrolase FtsQ PF03799.10 CCF32500.1 - 0.13 12.4 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Cell division protein FtsQ Pterin_4a PF01329.14 CCF32501.1 - 9.2e-29 99.0 0.1 1.2e-28 98.6 0.1 1.1 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase CPSF73-100_C PF11718.3 CCF32501.1 - 0.15 11.3 0.0 0.2 11.0 0.0 1.1 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term FA_hydroxylase PF04116.8 CCF32502.1 - 2.8e-15 56.7 17.0 2.8e-15 56.7 11.8 2.2 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily AAA PF00004.24 CCF32503.1 - 1.9e-45 154.2 0.6 6.1e-45 152.6 0.0 2.1 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CCF32503.1 - 9e-09 35.1 0.6 2.9e-08 33.5 0.1 2.1 2 2 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 CCF32503.1 - 4.7e-08 33.1 0.0 9.9e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 CCF32503.1 - 4.6e-07 29.9 0.0 1.5e-06 28.3 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CCF32503.1 - 7.7e-07 29.3 0.6 0.001 19.1 0.0 2.8 1 1 1 2 2 2 2 AAA domain DUF815 PF05673.8 CCF32503.1 - 2.9e-06 26.3 0.0 6.3e-06 25.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.1 CCF32503.1 - 0.00021 21.1 0.0 0.00083 19.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.7 CCF32503.1 - 0.00036 19.6 0.0 0.00085 18.4 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_28 PF13521.1 CCF32503.1 - 0.0004 20.3 0.0 0.00081 19.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 CCF32503.1 - 0.00054 19.6 1.0 0.057 13.0 0.0 3.3 3 1 0 4 4 4 1 NACHT domain AAA_17 PF13207.1 CCF32503.1 - 0.00068 20.4 0.2 0.0025 18.6 0.0 2.0 2 1 0 2 2 1 1 AAA domain TIP49 PF06068.8 CCF32503.1 - 0.0011 17.7 0.0 0.0021 16.8 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus Zeta_toxin PF06414.7 CCF32503.1 - 0.0013 17.8 0.1 0.0038 16.3 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin AAA_19 PF13245.1 CCF32503.1 - 0.0013 18.3 0.2 0.0035 17.0 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain RNA_helicase PF00910.17 CCF32503.1 - 0.0018 18.4 0.0 0.0038 17.3 0.0 1.6 1 0 0 1 1 1 1 RNA helicase NTPase_1 PF03266.10 CCF32503.1 - 0.0027 17.4 0.0 0.0089 15.7 0.0 1.9 2 0 0 2 2 1 1 NTPase AAA_3 PF07726.6 CCF32503.1 - 0.0037 16.8 0.0 0.011 15.2 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.1 CCF32503.1 - 0.0046 16.5 0.8 0.015 14.9 0.0 2.1 2 1 1 3 3 3 1 AAA domain AAA_33 PF13671.1 CCF32503.1 - 0.0053 16.6 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain UPF0079 PF02367.12 CCF32503.1 - 0.0054 16.3 0.0 0.041 13.5 0.0 2.1 1 1 1 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_23 PF13476.1 CCF32503.1 - 0.0055 17.0 1.3 0.83 9.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 CCF32503.1 - 0.006 15.7 0.2 0.013 14.6 0.1 1.7 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.1 CCF32503.1 - 0.0063 16.1 0.1 0.021 14.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 CCF32503.1 - 0.0082 16.4 0.0 0.025 14.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 CCF32503.1 - 0.0086 15.7 0.8 0.058 13.0 0.0 2.5 2 1 0 2 2 2 1 Archaeal ATPase IstB_IS21 PF01695.12 CCF32503.1 - 0.01 15.2 0.5 0.024 14.0 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_24 PF13479.1 CCF32503.1 - 0.011 15.3 0.5 0.03 13.9 0.1 1.8 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.13 CCF32503.1 - 0.016 14.9 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein Viral_Hsp90 PF03225.9 CCF32503.1 - 0.016 13.5 0.0 0.024 12.9 0.0 1.2 1 0 0 1 1 1 0 Viral heat shock protein Hsp90 homologue AAA_25 PF13481.1 CCF32503.1 - 0.018 14.4 2.5 0.07 12.5 0.1 2.4 2 1 1 3 3 3 0 AAA domain KaiC PF06745.8 CCF32503.1 - 0.028 13.5 1.3 0.45 9.5 0.0 2.6 3 0 0 3 3 3 0 KaiC Sigma54_activat PF00158.21 CCF32503.1 - 0.04 13.3 0.1 1.3 8.4 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain AFG1_ATPase PF03969.11 CCF32503.1 - 0.046 12.5 0.0 0.13 11.0 0.0 1.7 2 0 0 2 2 2 0 AFG1-like ATPase Sigma54_activ_2 PF14532.1 CCF32503.1 - 0.056 13.4 0.1 0.37 10.8 0.0 2.4 2 1 0 2 2 2 0 Sigma-54 interaction domain Cast PF10174.4 CCF32503.1 - 0.065 11.2 2.2 0.11 10.4 0.9 1.7 2 0 0 2 2 2 0 RIM-binding protein of the cytomatrix active zone NB-ARC PF00931.17 CCF32503.1 - 0.11 11.2 0.0 0.2 10.4 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Parvo_NS1 PF01057.12 CCF32503.1 - 0.17 10.7 0.0 0.31 9.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 CENP-U PF13097.1 CCF32504.1 - 0.0056 16.6 1.1 0.0072 16.2 0.7 1.1 1 0 0 1 1 1 1 CENP-A nucleosome associated complex (NAC) subunit Mis14 PF08641.7 CCF32505.1 - 3.4e-09 36.8 0.3 4.9e-09 36.3 0.2 1.3 1 0 0 1 1 1 1 Kinetochore protein Mis14 like UPF0075 PF03702.9 CCF32505.1 - 0.13 11.1 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0075) CRAL_TRIO PF00650.15 CCF32506.1 - 4.7e-36 123.6 0.0 7e-36 123.1 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 CCF32506.1 - 2.7e-10 40.2 1.8 4.6e-10 39.4 0.2 2.2 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 CCF32506.1 - 0.0018 18.1 0.0 0.016 15.1 0.0 2.2 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain Prefoldin PF02996.12 CCF32507.1 - 9.1e-35 118.9 0.0 1.4e-34 118.3 0.0 1.3 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.15 CCF32507.1 - 0.00053 19.7 5.5 0.0018 17.9 0.0 2.8 3 1 0 3 3 3 1 Prefoldin subunit Filament PF00038.16 CCF32507.1 - 0.012 15.1 1.7 0.49 9.8 0.1 2.1 2 0 0 2 2 2 0 Intermediate filament protein HR1 PF02185.11 CCF32507.1 - 0.018 14.7 0.2 0.071 12.8 0.0 1.9 2 0 0 2 2 2 0 Hr1 repeat End3 PF12761.2 CCF32507.1 - 0.031 13.8 0.5 0.22 11.1 0.2 2.2 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 FlaC_arch PF05377.6 CCF32507.1 - 0.036 13.9 1.4 1.7 8.5 0.1 3.0 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF4201 PF13870.1 CCF32507.1 - 0.32 10.4 4.4 0.54 9.6 0.2 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) Mito_carr PF00153.22 CCF32508.1 - 8.6e-61 201.6 3.2 4.6e-21 74.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein RINT1_TIP1 PF04437.8 CCF32509.1 - 1.7e-94 317.1 0.0 2.9e-94 316.3 0.0 1.4 1 0 0 1 1 1 1 RINT-1 / TIP-1 family Myosin_tail_1 PF01576.14 CCF32509.1 - 0.0067 14.2 4.5 0.011 13.5 3.1 1.2 1 0 0 1 1 1 1 Myosin tail DUF883 PF05957.8 CCF32509.1 - 0.014 15.8 3.9 9.3 6.7 0.5 3.8 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Gluconate_2-dh3 PF13618.1 CCF32509.1 - 0.23 11.6 3.7 0.45 10.6 0.9 2.6 2 0 0 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 DUF4164 PF13747.1 CCF32509.1 - 0.37 10.9 9.9 0.16 12.1 3.2 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) COG2 PF06148.6 CCF32509.1 - 1.8 8.4 7.0 44 3.9 3.2 3.4 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Ank_5 PF13857.1 CCF32511.1 - 5.5e-12 45.5 0.0 1e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 CCF32511.1 - 1.2e-10 40.6 0.8 7.5e-08 31.8 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 CCF32511.1 - 8.9e-10 38.7 0.0 1.6e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF32511.1 - 4.1e-08 33.5 0.3 5.8e-07 29.8 0.0 2.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF32511.1 - 2.3e-05 24.2 0.1 0.00022 21.1 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat Trypsin_2 PF13365.1 CCF32512.1 - 0.0021 18.0 0.0 0.0058 16.6 0.0 1.8 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S3 PF00944.14 CCF32512.1 - 0.025 14.0 0.1 0.043 13.2 0.0 1.3 1 0 0 1 1 1 0 Alphavirus core protein Atg14 PF10186.4 CCF32512.1 - 0.053 12.4 0.2 0.077 11.9 0.1 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 HAD PF12710.2 CCF32514.1 - 4.3e-14 53.1 0.0 5.1e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 CCF32514.1 - 0.00029 21.1 0.0 0.0004 20.6 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase UMPH-1 PF05822.7 CCF32514.1 - 0.016 14.5 0.0 0.032 13.5 0.0 1.6 1 1 1 2 2 2 0 Pyrimidine 5'-nucleotidase (UMPH-1) NACHT PF05729.7 CCF32515.1 - 1.9e-09 37.3 0.1 4.3e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 CCF32515.1 - 3.1e-06 27.2 0.9 1.1e-05 25.4 0.1 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 CCF32515.1 - 0.00024 21.2 0.1 0.0014 18.8 0.0 2.4 2 1 0 2 2 1 1 AAA domain AAA PF00004.24 CCF32515.1 - 0.005 17.0 0.0 0.021 15.0 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 CCF32515.1 - 0.0061 16.4 0.0 0.037 13.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 CCF32515.1 - 0.0084 15.8 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Archaeal ATPase RNA_helicase PF00910.17 CCF32515.1 - 0.0085 16.2 0.0 0.02 15.0 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_19 PF13245.1 CCF32515.1 - 0.015 15.0 0.0 0.043 13.5 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain NTPase_1 PF03266.10 CCF32515.1 - 0.022 14.4 0.0 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 NTPase APS_kinase PF01583.15 CCF32515.1 - 0.023 14.3 0.0 0.053 13.1 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_17 PF13207.1 CCF32515.1 - 0.04 14.7 1.7 0.11 13.3 0.2 2.7 2 2 0 2 2 2 0 AAA domain AAA_30 PF13604.1 CCF32515.1 - 0.055 13.0 0.0 0.14 11.7 0.0 1.6 2 0 0 2 2 1 0 AAA domain MobB PF03205.9 CCF32515.1 - 0.077 12.7 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B IstB_IS21 PF01695.12 CCF32515.1 - 0.1 11.9 0.0 0.26 10.6 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_29 PF13555.1 CCF32515.1 - 0.1 12.1 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain PIF1 PF05970.9 CCF32515.1 - 0.11 11.4 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase Mg_chelatase PF01078.16 CCF32515.1 - 0.13 11.4 0.0 0.48 9.5 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 CCF32515.1 - 0.14 11.9 0.0 0.35 10.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) MFS_1 PF07690.11 CCF32516.1 - 7.5e-19 67.6 33.7 2.1e-10 39.8 11.4 3.0 1 1 2 3 3 3 3 Major Facilitator Superfamily Fungal_trans PF04082.13 CCF32517.1 - 2.9e-25 88.6 0.1 4.7e-25 87.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF32517.1 - 0.01 15.7 10.4 0.019 14.8 7.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Amidohydro_4 PF13147.1 CCF32518.1 - 1e-11 45.4 0.1 1.4e-11 45.0 0.1 1.2 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 CCF32518.1 - 7.5e-11 42.2 0.0 9.9e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 CCF32518.1 - 9.9e-08 31.5 0.0 1.5e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase family Acyl_transf_1 PF00698.16 CCF32519.1 - 1.5e-50 172.3 0.0 3e-50 171.3 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.21 CCF32519.1 - 2.1e-49 168.3 0.2 4.1e-49 167.3 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.5 CCF32519.1 - 4.6e-44 150.2 0.0 2.8e-43 147.7 0.0 2.3 2 0 0 2 2 2 1 KR domain PS-DH PF14765.1 CCF32519.1 - 9.5e-41 139.8 0.1 1.8e-40 138.9 0.1 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.20 CCF32519.1 - 8.3e-34 116.9 0.0 4.3e-33 114.5 0.0 2.3 2 0 0 2 2 2 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 CCF32519.1 - 1.6e-28 98.9 0.0 5e-28 97.3 0.0 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.7 CCF32519.1 - 1.2e-18 67.3 0.0 2.7e-18 66.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF32519.1 - 5.8e-12 45.6 0.0 1.4e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF32519.1 - 2.2e-10 41.1 0.0 7.4e-10 39.4 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF32519.1 - 3.4e-09 36.4 0.0 6.8e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF32519.1 - 6.6e-09 36.1 0.0 1.4e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.18 CCF32519.1 - 1.2e-07 30.9 0.0 2.2e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Ubie_methyltran PF01209.13 CCF32519.1 - 1.4e-05 24.2 0.0 3e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 CCF32519.1 - 2.4e-05 24.6 0.0 6e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.20 CCF32519.1 - 6e-05 23.2 0.1 0.00018 21.6 0.1 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_16 PF10294.4 CCF32519.1 - 0.0013 18.2 0.0 0.0025 17.3 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_28 PF02636.12 CCF32519.1 - 0.022 14.1 0.0 0.044 13.1 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase RrnaAD PF00398.15 CCF32519.1 - 0.031 13.3 0.0 0.05 12.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase NUMOD1 PF07453.8 CCF32519.1 - 0.66 9.9 0.0 1.4 8.8 0.0 1.5 1 0 0 1 1 1 0 NUMOD1 domain OPT PF03169.10 CCF32521.1 - 9.7e-175 582.5 51.7 1.1e-174 582.3 35.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein RAMP4 PF06624.7 CCF32521.1 - 0.27 10.7 2.2 11 5.6 0.3 2.7 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 PPR_2 PF13041.1 CCF32523.1 - 4.4e-24 84.2 0.0 1.2e-07 31.5 0.0 4.6 4 1 1 5 5 5 4 PPR repeat family PPR_3 PF13812.1 CCF32523.1 - 4.9e-17 60.7 0.6 0.00019 21.4 0.0 6.0 6 0 0 6 6 6 4 Pentatricopeptide repeat domain PPR_1 PF12854.2 CCF32523.1 - 1.5e-15 56.3 0.0 1.7e-05 24.1 0.0 5.4 5 0 0 5 5 5 4 PPR repeat PPR PF01535.15 CCF32523.1 - 7e-15 53.8 0.0 7.2e-05 22.5 0.0 5.4 5 1 0 5 5 5 3 PPR repeat EMP24_GP25L PF01105.19 CCF32524.1 - 1.6e-54 184.4 0.0 1.8e-54 184.2 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD HXXSHH PF07586.6 CCF32524.1 - 0.072 12.0 0.1 0.1 11.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) DUF809 PF05663.6 CCF32525.1 - 0.00069 19.5 0.3 0.00069 19.5 0.2 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF809) Myb_DNA-bind_6 PF13921.1 CCF32525.1 - 0.071 13.2 0.3 0.22 11.6 0.0 2.0 2 0 0 2 2 2 0 Myb-like DNA-binding domain Pkinase PF00069.20 CCF32527.1 - 4e-42 144.1 0.3 4.2e-25 88.3 0.1 2.6 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CCF32527.1 - 3.2e-15 55.9 0.2 2e-10 40.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Spore-coat_CotD PF11122.3 CCF32527.1 - 0.12 12.7 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 Inner spore coat protein D Aldo_ket_red PF00248.16 CCF32529.1 - 5e-21 74.7 0.0 1.1e-19 70.3 0.0 2.1 1 1 0 1 1 1 1 Aldo/keto reductase family GFO_IDH_MocA PF01408.17 CCF32530.1 - 3.4e-18 66.3 0.2 5.4e-18 65.6 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold OpuAC PF04069.7 CCF32530.1 - 0.044 13.1 0.0 1.9 7.7 0.0 2.4 2 0 0 2 2 2 0 Substrate binding domain of ABC-type glycine betaine transport system Semialdhyde_dh PF01118.19 CCF32530.1 - 0.067 13.5 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Glyco_hydro_61 PF03443.9 CCF32531.1 - 6.4e-23 81.7 0.1 6.7e-23 81.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 fn3 PF00041.16 CCF32531.1 - 0.11 12.6 0.0 0.13 12.4 0.0 1.1 1 0 0 1 1 1 0 Fibronectin type III domain DEAD PF00270.24 CCF32532.1 - 8.4e-37 126.2 0.1 1.4e-36 125.5 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF32532.1 - 8e-24 83.3 0.0 6.1e-23 80.4 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF32532.1 - 3.3e-05 23.8 0.1 9.2e-05 22.3 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.1 CCF32532.1 - 0.015 14.3 0.2 0.11 11.4 0.1 2.1 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Rpr2 PF04032.11 CCF32533.1 - 2.4e-20 72.1 0.6 3.4e-20 71.6 0.4 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Pyridoxal_deC PF00282.14 CCF32534.1 - 1.6e-63 214.3 0.0 2.3e-63 213.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.14 CCF32534.1 - 0.00056 18.7 0.0 0.00098 17.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V CBF PF03914.12 CCF32538.1 - 6.3e-43 146.0 0.4 1.9e-42 144.5 0.1 2.0 2 0 0 2 2 2 1 CBF/Mak21 family DIOX_N PF14226.1 CCF32539.1 - 5.4e-12 46.2 0.0 7.4e-12 45.8 0.0 1.1 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal OPT PF03169.10 CCF32541.1 - 1.2e-133 446.8 53.2 1.3e-133 446.6 36.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein MFS_1 PF07690.11 CCF32545.1 - 6.6e-19 67.8 59.7 9.9e-15 54.0 30.6 3.4 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF32545.1 - 6e-13 47.8 25.1 9.1e-13 47.2 17.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.11 CCF32546.1 - 1.1e-08 34.2 33.1 1.1e-08 34.2 22.9 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 CCF32546.1 - 2.6e-06 27.0 2.6 2.6e-06 27.0 1.8 2.5 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 CVNH PF08881.5 CCF32547.1 - 5.2e-09 36.2 0.0 6.9e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 CVNH domain DUF1968 PF09291.5 CCF32547.1 - 0.0084 15.8 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1968) GCC2_GCC3 PF07699.8 CCF32547.1 - 0.029 13.9 0.4 0.12 12.0 0.2 2.0 1 0 0 1 1 1 0 GCC2 and GCC3 Fungal_trans_2 PF11951.3 CCF32548.1 - 3e-07 29.3 0.1 2.6e-06 26.2 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF32548.1 - 1.6e-05 24.7 4.1 1.6e-05 24.7 2.8 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SEN1_N PF12726.2 CCF32548.1 - 0.047 11.7 0.3 1.1 7.1 0.0 2.4 3 0 0 3 3 3 0 SEN1 N terminal Beta-lactamase PF00144.19 CCF32549.1 - 2e-37 128.9 0.1 3.2e-37 128.2 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase Hydantoinase_A PF01968.13 CCF32549.1 - 0.0059 15.7 0.0 0.97 8.4 0.0 2.1 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase FAT PF02259.18 CCF32550.1 - 1.2e-127 425.6 9.7 2.5e-127 424.6 6.7 1.6 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.22 CCF32550.1 - 1.1e-62 211.5 0.4 2.4e-62 210.5 0.2 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.3 CCF32550.1 - 3.9e-62 208.9 0.2 3e-60 202.7 0.1 3.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3385) Rapamycin_bind PF08771.6 CCF32550.1 - 1e-43 147.4 0.3 1e-43 147.4 0.2 3.1 3 0 0 3 3 3 1 Rapamycin binding domain HEAT_2 PF13646.1 CCF32550.1 - 1.2e-16 60.7 14.5 0.00014 22.0 0.4 8.9 6 3 4 10 10 10 4 HEAT repeats FATC PF02260.15 CCF32550.1 - 1.7e-14 52.9 0.1 4e-14 51.7 0.1 1.7 1 0 0 1 1 1 1 FATC domain HEAT PF02985.17 CCF32550.1 - 8.2e-13 47.2 23.2 0.002 18.0 0.0 11.2 11 0 0 11 11 11 2 HEAT repeat HEAT_EZ PF13513.1 CCF32550.1 - 1.3e-09 38.2 21.5 0.00026 21.3 0.3 11.7 10 2 2 12 12 12 2 HEAT-like repeat Vac14_Fab1_bd PF12755.2 CCF32550.1 - 6.8e-06 26.3 0.8 64 4.0 0.0 7.6 7 2 1 8 8 7 0 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.15 CCF32550.1 - 5e-05 21.8 8.6 0.007 14.7 0.1 4.0 3 1 0 4 4 4 3 Adaptin N terminal region Baculo_PEP_C PF04513.7 CCF32550.1 - 0.012 15.4 0.8 0.12 12.2 0.1 3.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Rtf2 PF04641.7 CCF32551.1 - 1.7e-51 174.9 0.2 2.1e-51 174.6 0.2 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_UBOX PF13445.1 CCF32551.1 - 2.2e-05 24.0 0.1 8.3e-05 22.2 0.0 2.1 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.1 CCF32551.1 - 0.0023 17.5 0.1 0.0038 16.9 0.1 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 CCF32551.1 - 0.0071 16.1 0.1 0.021 14.6 0.1 1.7 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 CCF32551.1 - 0.022 14.7 0.6 0.043 13.8 0.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF32551.1 - 0.051 13.2 0.1 0.088 12.4 0.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.3 CCF32551.1 - 0.054 13.0 0.1 0.33 10.4 0.2 2.0 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit UPF0547 PF10571.4 CCF32551.1 - 0.18 11.5 3.0 11 5.8 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 PRKCSH-like PF12999.2 CCF32552.1 - 3.9e-41 140.5 5.1 1.1e-22 80.4 0.4 3.0 3 0 0 3 3 3 2 Glucosidase II beta subunit-like PRKCSH_1 PF13015.1 CCF32552.1 - 3.9e-31 107.5 7.5 4.4e-31 107.4 0.5 2.6 3 0 0 3 3 2 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.8 CCF32552.1 - 7e-10 39.5 1.8 1.1e-09 38.8 0.5 2.0 2 0 0 2 2 1 1 Glucosidase II beta subunit-like protein IncA PF04156.9 CCF32552.1 - 0.00099 18.7 14.1 0.032 13.8 4.0 3.0 3 0 0 3 3 3 2 IncA protein NPV_P10 PF05531.7 CCF32552.1 - 0.0011 19.1 1.2 0.47 10.7 0.0 2.5 2 0 0 2 2 2 1 Nucleopolyhedrovirus P10 protein Snapin_Pallidin PF14712.1 CCF32552.1 - 0.0041 17.3 3.7 0.069 13.4 0.0 2.5 2 0 0 2 2 2 1 Snapin/Pallidin OmpH PF03938.9 CCF32552.1 - 0.0095 15.8 2.5 0.083 12.8 0.3 2.4 2 1 0 2 2 2 1 Outer membrane protein (OmpH-like) NuA4 PF09340.5 CCF32552.1 - 0.01 15.4 9.4 0.25 11.0 0.0 3.9 3 0 0 3 3 3 0 Histone acetyltransferase subunit NuA4 Prominin PF05478.6 CCF32552.1 - 0.013 13.0 0.5 0.019 12.5 0.3 1.1 1 0 0 1 1 1 0 Prominin DUF4559 PF15112.1 CCF32552.1 - 0.015 14.4 3.6 0.033 13.3 2.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) TPR_MLP1_2 PF07926.7 CCF32552.1 - 0.017 14.8 17.9 0.28 10.9 4.9 3.3 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF641 PF04859.7 CCF32552.1 - 0.042 13.6 7.6 1.1 8.9 3.6 2.4 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) DUF3086 PF11285.3 CCF32552.1 - 0.096 11.4 0.0 0.096 11.4 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3086) PilJ PF13675.1 CCF32552.1 - 0.15 12.4 5.0 4.3 7.6 0.3 3.0 3 0 0 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Filament PF00038.16 CCF32552.1 - 0.21 11.0 19.5 0.39 10.1 3.9 3.0 2 1 1 3 3 3 0 Intermediate filament protein DUF1664 PF07889.7 CCF32552.1 - 0.21 11.3 5.5 0.87 9.3 1.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4407 PF14362.1 CCF32552.1 - 0.24 10.3 7.8 0.23 10.3 3.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) BLOC1_2 PF10046.4 CCF32552.1 - 0.52 10.4 6.1 0.99 9.5 1.3 2.5 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4047 PF13256.1 CCF32552.1 - 0.57 10.1 5.0 2.7 7.9 2.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4047) Herpes_UL6 PF01763.11 CCF32552.1 - 0.64 8.1 4.8 1.8 6.6 3.2 1.7 1 1 1 2 2 2 0 Herpesvirus UL6 like Fib_alpha PF08702.5 CCF32552.1 - 0.69 10.0 6.5 6.6 6.8 2.4 2.8 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Syntaxin-6_N PF09177.6 CCF32552.1 - 0.85 10.0 7.6 2.7 8.4 0.8 3.3 3 0 0 3 3 3 0 Syntaxin 6, N-terminal Mod_r PF07200.8 CCF32552.1 - 1.1 9.2 11.3 5.1 6.9 0.0 3.0 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Fzo_mitofusin PF04799.8 CCF32552.1 - 1.4 8.2 8.2 5.1 6.4 0.8 2.8 3 0 0 3 3 3 0 fzo-like conserved region DUF3450 PF11932.3 CCF32552.1 - 1.5 8.0 5.8 2 7.6 2.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) Phe_tRNA-synt_N PF02912.13 CCF32552.1 - 1.8 8.3 10.6 0.12 12.1 2.6 2.4 2 0 0 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain GAS PF13851.1 CCF32552.1 - 2.9 7.0 16.4 0.48 9.6 4.5 2.8 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Prefoldin_2 PF01920.15 CCF32552.1 - 5.5 6.8 16.3 4.2 7.1 4.0 3.5 3 1 0 3 3 3 0 Prefoldin subunit Apolipoprotein PF01442.13 CCF32552.1 - 8.1 5.8 12.4 36 3.7 8.5 1.9 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF3435 PF11917.3 CCF32552.1 - 8.3 5.0 8.4 2.2 6.8 2.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3435) FadA PF09403.5 CCF32552.1 - 9.4 6.2 13.9 4.1 7.4 0.1 3.1 3 0 0 3 3 3 0 Adhesion protein FadA GCIP PF13324.1 CCF32553.1 - 2.4e-05 23.6 0.2 7.5e-05 22.0 0.1 1.8 2 0 0 2 2 2 1 Grap2 and cyclin-D-interacting GYF PF02213.11 CCF32555.1 - 1.3e-19 69.5 0.1 2.7e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 GYF domain DUF2605 PF10792.4 CCF32555.1 - 4 7.1 4.7 0.86 9.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2605) TPR_2 PF07719.12 CCF32556.1 - 0.014 15.2 0.0 0.041 13.8 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.1 CCF32556.1 - 0.044 13.7 0.1 0.14 12.1 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.1 CCF32556.1 - 0.12 12.2 0.0 0.28 11.0 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF771 PF05595.6 CCF32556.1 - 0.16 11.9 0.0 0.45 10.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF771) Trp_DMAT PF11991.3 CCF32557.1 - 8.5e-68 229.1 0.0 1e-67 228.9 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Pro_isomerase PF00160.16 CCF32560.1 - 4e-40 137.5 0.0 7e-40 136.7 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD HSF_DNA-bind PF00447.12 CCF32561.1 - 1.9e-28 98.6 0.1 4.3e-28 97.5 0.1 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding Ets PF00178.17 CCF32561.1 - 0.092 12.8 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Ets-domain Cullin_binding PF03556.10 CCF32562.1 - 2e-32 111.7 4.6 2.5e-32 111.4 3.2 1.1 1 0 0 1 1 1 1 Cullin binding Ribosomal_S6 PF01250.12 CCF32563.1 - 4e-12 45.8 0.0 4.8e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 SQS_PSY PF00494.14 CCF32564.1 - 5.3e-53 180.0 1.7 6.5e-53 179.7 1.2 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase SNF2_N PF00176.18 CCF32565.1 - 5.7e-73 245.3 0.0 9.3e-73 244.6 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.6 CCF32565.1 - 1.1e-24 86.3 0.0 2.1e-24 85.4 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.26 CCF32565.1 - 1.5e-13 50.3 0.0 4.6e-13 48.8 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.1 CCF32565.1 - 5.4e-07 29.5 10.1 1.1e-06 28.5 7.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF32565.1 - 1.7e-06 27.5 11.3 3.2e-06 26.6 7.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.10 CCF32565.1 - 2.2e-06 27.6 0.0 1.6e-05 24.7 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit zf-RING_2 PF13639.1 CCF32565.1 - 8.5e-06 25.5 9.9 2.1e-05 24.2 6.8 1.7 1 0 0 1 1 1 1 Ring finger domain DEAD PF00270.24 CCF32565.1 - 2e-05 24.1 0.0 4.8e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_3 PF13920.1 CCF32565.1 - 3.3e-05 23.4 8.1 6.2e-05 22.5 5.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF32565.1 - 0.0095 15.6 8.7 0.022 14.4 6.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain PLU-1 PF08429.6 CCF32565.1 - 0.012 14.5 3.1 0.03 13.2 2.1 1.6 1 0 0 1 1 1 0 PLU-1-like protein UBA_4 PF14555.1 CCF32565.1 - 0.05 13.1 0.0 0.17 11.4 0.0 1.9 1 0 0 1 1 1 0 UBA-like domain Zn-ribbon_8 PF09723.5 CCF32565.1 - 0.68 9.9 4.1 9.3 6.2 0.7 2.8 2 0 0 2 2 2 0 Zinc ribbon domain zf-C3HC4_4 PF15227.1 CCF32565.1 - 3.4 7.6 9.0 7.1 6.5 6.2 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.1 CCF32565.1 - 7.5 6.2 10.5 55 3.4 7.1 2.3 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain PX PF00787.19 CCF32568.1 - 4e-21 74.9 0.0 5.6e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 PX domain p450 PF00067.17 CCF32569.1 - 3.5e-24 85.1 0.0 4.8e-24 84.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Fungal_trans_2 PF11951.3 CCF32570.1 - 7.9e-17 60.9 0.1 1e-16 60.5 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF32570.1 - 0.0004 20.2 7.0 0.0004 20.2 4.8 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2039 PF10217.4 CCF32570.1 - 0.21 11.6 2.1 0.52 10.3 1.5 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) PALP PF00291.20 CCF32571.1 - 8.1e-20 71.2 0.2 8.1e-20 71.2 0.1 1.5 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Methyltransf_28 PF02636.12 CCF32572.1 - 9.1e-41 139.9 0.0 1.4e-40 139.2 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PRMT5 PF05185.11 CCF32572.1 - 0.011 14.6 0.0 0.017 14.0 0.0 1.2 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase tRNA-synt_2c PF01411.14 CCF32573.1 - 1e-210 700.7 0.0 1.7e-210 700.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 CCF32573.1 - 5.1e-17 61.4 0.4 1.6e-16 59.9 0.3 1.9 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.14 CCF32573.1 - 5.3e-05 22.8 0.4 0.00017 21.2 0.3 2.0 1 0 0 1 1 1 1 DHHA1 domain RseA_C PF03873.8 CCF32574.1 - 3.1 7.7 6.0 2.1 8.2 1.8 2.1 2 0 0 2 2 2 0 Anti sigma-E protein RseA, C-terminal domain YrhK PF14145.1 CCF32575.1 - 0.013 15.1 23.1 0.91 9.2 1.0 5.1 4 1 1 5 5 5 0 YrhK-like protein CD20 PF04103.10 CCF32575.1 - 5.9 6.8 15.1 2.1 8.2 0.5 2.8 2 1 1 3 3 3 0 CD20-like family Caleosin PF05042.8 CCF32576.1 - 5.5e-58 195.3 0.0 6.7e-58 195.0 0.0 1.1 1 0 0 1 1 1 1 Caleosin related protein EF-hand_6 PF13405.1 CCF32576.1 - 0.073 12.9 0.5 27 5.0 0.1 3.2 3 0 0 3 3 3 0 EF-hand domain Glyco_hydro_3 PF00933.16 CCF32578.1 - 1.1e-60 205.1 0.0 1.6e-60 204.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain MaoC_dehydratas PF01575.14 CCF32579.1 - 2.1e-06 27.1 0.0 3.1e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.1 CCF32579.1 - 0.12 12.1 0.0 4.5 7.0 0.0 2.4 2 0 0 2 2 2 0 N-terminal half of MaoC dehydratase eRF1_2 PF03464.10 CCF32580.1 - 1.6e-45 154.6 0.0 2.9e-45 153.8 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 CCF32580.1 - 6.4e-41 139.1 0.6 1.3e-40 138.2 0.4 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.10 CCF32580.1 - 1.1e-28 99.3 0.2 2.2e-28 98.4 0.0 1.5 2 0 0 2 2 2 1 eRF1 domain 1 DUF1770 PF08589.5 CCF32581.1 - 4e-30 104.3 1.4 5.1e-30 104.0 0.9 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1770) Daxx PF03344.10 CCF32582.1 - 3 6.2 14.9 0.12 10.8 6.4 1.5 2 0 0 2 2 2 0 Daxx Family Nop14 PF04147.7 CCF32582.1 - 4 5.2 12.8 6.5 4.5 8.9 1.3 1 0 0 1 1 1 0 Nop14-like family Glyco_hydro_18 PF00704.23 CCF32583.1 - 4.6e-92 309.1 1.2 7e-92 308.5 0.9 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LRR_6 PF13516.1 CCF32584.1 - 5.1e-10 38.3 1.5 7.9 6.8 0.0 7.7 8 0 0 8 8 8 3 Leucine Rich repeat LRR_4 PF12799.2 CCF32584.1 - 5.6e-09 35.4 9.8 0.046 13.3 0.0 5.8 5 2 1 6 6 6 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 CCF32584.1 - 9.3e-07 28.0 1.6 6.1 7.2 0.0 6.5 6 2 1 7 7 7 2 Leucine Rich Repeat LRR_7 PF13504.1 CCF32584.1 - 0.0018 18.1 1.2 85 4.0 0.0 6.0 6 0 0 6 6 6 0 Leucine rich repeat LRR_8 PF13855.1 CCF32584.1 - 0.0035 17.0 9.9 4.1 7.2 1.6 5.1 4 2 2 6 6 6 2 Leucine rich repeat LETM1 PF07766.8 CCF32584.1 - 0.0041 16.1 0.0 0.0075 15.3 0.0 1.4 1 0 0 1 1 1 1 LETM1-like protein zf-H2C2_2 PF13465.1 CCF32585.1 - 4.8e-07 29.7 8.6 5.1e-06 26.5 0.9 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 CCF32585.1 - 4.7e-05 23.4 6.5 0.00024 21.1 0.3 3.0 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF32585.1 - 6.3e-05 23.0 0.5 6.3e-05 23.0 0.4 3.7 3 1 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 CCF32585.1 - 1 9.5 7.8 1.3 9.2 0.4 3.1 3 1 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Cytochrom_B_N PF00033.14 CCF32586.1 - 0.00023 20.5 0.1 0.0019 17.5 0.1 1.9 2 0 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB PepSY_TM PF03929.11 CCF32586.1 - 1.5 9.3 6.5 6.2 7.4 0.8 2.6 2 0 0 2 2 2 0 PepSY-associated TM helix Fe_hyd_lg_C PF02906.9 CCF32587.1 - 8.8e-62 208.9 0.0 2.4e-61 207.4 0.0 1.7 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain SUZ PF12752.2 CCF32588.1 - 0.001 19.5 5.5 0.001 19.5 3.8 3.9 3 2 0 3 3 3 1 SUZ domain CRF PF00473.12 CCF32588.1 - 0.14 12.2 3.6 0.27 11.3 0.0 2.2 2 0 0 2 2 2 0 Corticotropin-releasing factor family API5 PF05918.6 CCF32588.1 - 0.39 9.1 3.6 0.54 8.6 2.5 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) DUF4658 PF15555.1 CCF32591.1 - 0.043 13.6 0.1 0.093 12.6 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4658) SQS_PSY PF00494.14 CCF32592.1 - 6.5e-39 133.8 0.0 2.7e-38 131.7 0.0 1.8 2 0 0 2 2 2 1 Squalene/phytoene synthase RmlD_sub_bind PF04321.12 CCF32593.1 - 1.3e-15 57.0 0.0 3.3e-15 55.7 0.0 1.6 1 1 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.16 CCF32593.1 - 1.3e-11 44.3 0.0 2.9e-11 43.2 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 CCF32593.1 - 0.0014 17.5 0.0 0.0022 16.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 CCF32593.1 - 0.019 14.8 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase 3Beta_HSD PF01073.14 CCF32593.1 - 0.023 13.4 0.1 0.14 10.8 0.0 1.9 1 1 1 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Macro PF01661.16 CCF32593.1 - 0.09 12.6 0.1 0.33 10.8 0.0 2.0 2 1 0 2 2 2 0 Macro domain C2-set_2 PF08205.7 CCF32593.1 - 0.1 12.5 0.2 0.24 11.3 0.1 1.6 1 1 0 1 1 1 0 CD80-like C2-set immunoglobulin domain DnaJ PF00226.26 CCF32594.1 - 1.8e-28 98.0 1.1 3.5e-28 97.1 0.8 1.5 1 0 0 1 1 1 1 DnaJ domain Sigma70_ner PF04546.8 CCF32594.1 - 0.3 10.6 3.2 0.74 9.3 0.0 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region Arm PF00514.18 CCF32595.1 - 1e-94 307.4 14.9 1.9e-13 49.6 0.1 8.4 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 CCF32595.1 - 5.2e-28 97.1 1.7 7.8e-10 38.9 0.0 5.9 1 1 6 7 7 7 6 HEAT repeats HEAT_EZ PF13513.1 CCF32595.1 - 1.6e-21 76.1 14.4 1.2e-09 38.3 0.1 6.5 6 1 2 8 8 7 4 HEAT-like repeat HEAT PF02985.17 CCF32595.1 - 8.9e-21 72.0 1.5 4.4e-06 26.3 0.0 7.1 7 0 0 7 7 7 4 HEAT repeat IBB PF01749.15 CCF32595.1 - 1.4e-19 69.9 0.5 2.7e-19 69.1 0.4 1.4 1 0 0 1 1 1 1 Importin beta binding domain Arm_2 PF04826.8 CCF32595.1 - 2.3e-10 40.0 0.0 0.014 14.5 0.0 4.1 2 1 2 4 4 4 3 Armadillo-like Adaptin_N PF01602.15 CCF32595.1 - 1.5e-05 23.5 0.0 0.0015 16.9 0.0 2.8 1 1 0 2 2 2 1 Adaptin N terminal region V-ATPase_H_C PF11698.3 CCF32595.1 - 0.00029 20.7 0.0 1.6 8.6 0.0 4.4 2 1 4 6 6 6 2 V-ATPase subunit H HEAT_PBS PF03130.11 CCF32595.1 - 0.00062 19.9 0.2 1.4 9.5 0.0 4.5 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat Proteasom_PSMB PF10508.4 CCF32595.1 - 0.0016 16.8 0.1 0.25 9.5 0.0 2.9 2 1 1 3 3 3 2 Proteasome non-ATPase 26S subunit Glycos_trans_3N PF02885.12 CCF32595.1 - 0.074 12.6 0.0 18 4.9 0.0 3.4 3 0 0 3 3 3 0 Glycosyl transferase family, helical bundle domain Med5 PF08689.5 CCF32596.1 - 3.2e-243 809.7 0.0 3.7e-243 809.4 0.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit Med5 SSF PF00474.12 CCF32596.1 - 0.0033 16.1 0.2 0.0056 15.3 0.1 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family LigB PF02900.13 CCF32597.1 - 3.4e-13 49.2 0.1 7.5e-13 48.0 0.1 1.6 1 1 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase RicinB_lectin_2 PF14200.1 CCF32598.1 - 0.018 15.4 0.0 0.07 13.5 0.0 2.0 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like P33MONOX PF15302.1 CCF32598.1 - 0.057 13.0 2.0 0.5 9.9 0.2 2.0 1 1 0 2 2 2 0 P33 mono-oxygenase HSDR_N_2 PF13588.1 CCF32599.1 - 0.00026 20.7 0.0 0.00026 20.7 0.0 1.1 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) LysM PF01476.15 CCF32599.1 - 0.039 13.8 0.0 0.056 13.3 0.0 1.3 1 0 0 1 1 1 0 LysM domain Fungal_trans_2 PF11951.3 CCF32600.1 - 0.00012 20.7 4.3 0.00012 20.7 2.9 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Peptidase_M24 PF00557.19 CCF32602.1 - 7.6e-49 166.1 0.0 1.1e-48 165.5 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 CCF32602.1 - 7.1e-37 125.7 0.0 1.3e-36 124.9 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain HLH PF00010.21 CCF32603.1 - 7.4e-10 38.3 0.0 1.4e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain LysM PF01476.15 CCF32604.1 - 0.0026 17.6 0.0 0.0046 16.8 0.0 1.4 1 0 0 1 1 1 1 LysM domain TRP PF06011.7 CCF32605.1 - 1.9e-93 313.4 25.7 5.9e-93 311.8 17.8 1.7 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 CCF32605.1 - 4.5e-29 101.2 0.1 7.6e-29 100.5 0.0 1.3 1 0 0 1 1 1 1 ML-like domain Semialdhyde_dhC PF02774.13 CCF32606.1 - 5.8e-30 104.5 0.1 1.9e-25 89.7 0.0 2.2 1 1 1 2 2 2 2 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.19 CCF32606.1 - 4.5e-22 78.6 0.0 1.9e-20 73.3 0.0 2.8 2 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 CCF32606.1 - 0.00049 20.0 0.0 0.0014 18.5 0.0 1.7 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Gp_dh_C PF02800.15 CCF32606.1 - 0.011 15.2 0.0 0.022 14.2 0.0 1.5 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain SET_assoc PF11767.3 CCF32606.1 - 0.046 13.0 0.0 0.09 12.0 0.0 1.4 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated dCMP_cyt_deam_1 PF00383.17 CCF32607.1 - 1.4e-07 31.0 0.0 3.7e-07 29.7 0.0 1.7 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Fungal_trans PF04082.13 CCF32608.1 - 4.7e-26 91.2 0.0 8.5e-26 90.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF32608.1 - 2.8e-07 30.3 12.6 5.1e-07 29.4 8.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BatA PF07584.6 CCF32608.1 - 0.039 14.1 2.8 23 5.2 0.1 4.2 4 0 0 4 4 4 0 Aerotolerance regulator N-terminal Aminotran_1_2 PF00155.16 CCF32611.1 - 7.2e-08 31.7 0.0 1.7e-05 23.9 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class I and II Ribosomal_L4 PF00573.17 CCF32612.1 - 5.1e-38 130.3 0.6 7e-38 129.9 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.1 CCF32612.1 - 1.1e-26 92.5 1.9 1.1e-26 92.5 1.3 1.8 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain AA_permease_2 PF13520.1 CCF32613.1 - 5.5e-43 147.0 37.9 7.9e-43 146.5 26.3 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF32613.1 - 2.9e-24 85.2 24.1 2.9e-24 85.2 16.7 2.3 2 0 0 2 2 2 2 Amino acid permease DUF4538 PF15061.1 CCF32613.1 - 8.5 5.7 5.8 1.8 7.9 0.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4538) Glyco_hydro_76 PF03663.9 CCF32615.1 - 2.4e-151 504.3 11.9 2.9e-151 504.0 8.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Dak1 PF02733.12 CCF32616.1 - 9.8e-112 372.7 5.3 1.3e-111 372.3 3.7 1.1 1 0 0 1 1 1 1 Dak1 domain DUF159 PF02586.9 CCF32617.1 - 9.9e-54 182.0 0.0 1.6e-53 181.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, COG2135 RNA_pol_Rpb1_1 PF04997.7 CCF32618.1 - 2.8e-86 289.8 0.0 4.6e-86 289.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.12 CCF32618.1 - 7.8e-85 284.4 0.2 1.3e-84 283.7 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 CCF32618.1 - 1.6e-67 226.6 0.0 3.2e-67 225.6 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 CCF32618.1 - 8e-40 136.1 0.0 2.6e-39 134.4 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 CCF32618.1 - 5.9e-29 99.9 0.1 2.1e-28 98.2 0.1 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 DEAD PF00270.24 CCF32621.1 - 1e-46 158.5 0.1 3.2e-44 150.3 0.0 2.1 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF32621.1 - 4.2e-10 39.3 0.0 2.1e-09 37.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF32621.1 - 5.3e-05 23.1 0.0 8.2e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.9 CCF32621.1 - 0.0027 17.3 0.0 0.0045 16.6 0.0 1.3 1 0 0 1 1 1 1 Helicase AAA_19 PF13245.1 CCF32621.1 - 0.0043 16.7 0.6 0.016 14.9 0.2 2.2 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 CCF32621.1 - 0.0095 15.5 0.0 0.02 14.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 CCF32621.1 - 0.02 14.5 0.0 1.3 8.5 0.0 2.3 1 1 0 2 2 2 0 AAA domain AAA_22 PF13401.1 CCF32621.1 - 0.068 13.3 1.0 0.31 11.1 0.7 2.0 1 1 0 1 1 1 0 AAA domain SecA_DEAD PF07517.9 CCF32621.1 - 0.15 11.3 0.0 0.27 10.4 0.0 1.4 1 0 0 1 1 1 0 SecA DEAD-like domain DUF2075 PF09848.4 CCF32621.1 - 0.15 11.0 0.0 0.45 9.4 0.0 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) A_deaminase PF00962.17 CCF32623.1 - 2.4e-32 112.1 0.0 3.3e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase TatD_DNase PF01026.16 CCF32623.1 - 0.022 13.9 0.0 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 TatD related DNase Tom22 PF04281.8 CCF32625.1 - 1.6e-38 131.3 0.0 2e-38 131.0 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 MFS_1 PF07690.11 CCF32626.1 - 3.6e-10 39.0 19.9 4.4e-10 38.8 13.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4291 PF14124.1 CCF32627.1 - 1.3e-59 200.8 0.1 2.1e-59 200.2 0.1 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4291) Git3 PF11710.3 CCF32628.1 - 3.3e-16 59.4 6.5 3.3e-16 59.4 4.5 1.7 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.16 CCF32628.1 - 5.8e-09 35.4 6.8 1.1e-08 34.6 4.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dicty_CAR PF05462.6 CCF32628.1 - 0.0018 17.2 7.2 0.0034 16.3 5.0 1.4 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Git3_C PF11970.3 CCF32628.1 - 0.05 13.3 0.0 0.05 13.3 0.0 2.1 3 0 0 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term YjgP_YjgQ PF03739.9 CCF32628.1 - 0.078 11.7 0.1 0.078 11.7 0.1 2.4 2 0 0 2 2 2 0 Predicted permease YjgP/YjgQ family TMEM169 PF15052.1 CCF32628.1 - 1.4 8.7 8.7 16 5.3 3.8 2.6 2 0 0 2 2 2 0 TMEM169 protein family Abhydro_lipase PF04083.11 CCF32629.1 - 4.6e-21 73.9 0.1 1e-20 72.8 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.15 CCF32629.1 - 2.1e-18 66.7 0.0 4.7e-18 65.5 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF32629.1 - 5.9e-07 29.5 0.0 1.4e-06 28.3 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 CCF32629.1 - 7.8e-05 22.2 0.1 0.08 12.3 0.0 2.2 2 0 0 2 2 2 2 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 CCF32629.1 - 0.0001 22.1 0.0 0.00048 19.9 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 CCF32629.1 - 0.085 12.2 0.1 7.8 5.8 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Pet191_N PF10203.4 CCF32630.1 - 3.7e-28 97.3 5.3 4.7e-28 97.0 3.7 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 PAN_3 PF08277.7 CCF32630.1 - 0.081 12.5 0.6 0.14 11.7 0.4 1.4 1 0 0 1 1 1 0 PAN-like domain Clusterin PF01093.12 CCF32630.1 - 0.35 9.6 2.7 0.41 9.3 1.9 1.1 1 0 0 1 1 1 0 Clusterin MFS_1 PF07690.11 CCF32631.1 - 3.5e-35 121.3 74.3 1.2e-28 99.8 30.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CCF32631.1 - 1e-11 43.9 16.9 1e-11 43.9 11.7 2.1 1 1 1 2 2 2 1 MFS/sugar transport protein Sugar_tr PF00083.19 CCF32631.1 - 0.0014 17.2 17.0 0.0014 17.2 11.8 3.7 2 2 1 4 4 4 2 Sugar (and other) transporter MFS_1_like PF12832.2 CCF32631.1 - 0.002 17.8 2.9 0.011 15.4 2.0 2.3 1 0 0 1 1 1 1 MFS_1 like family Alpha_GJ PF03229.8 CCF32631.1 - 0.033 14.5 1.8 0.067 13.5 0.6 2.0 2 0 0 2 2 2 0 Alphavirus glycoprotein J AIM24 PF01987.12 CCF32632.1 - 3.8e-50 170.3 0.0 5.2e-50 169.8 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 DUF4402 PF14352.1 CCF32632.1 - 0.091 13.2 0.2 0.23 11.8 0.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4402) Kinesin PF00225.18 CCF32633.1 - 1.4e-81 273.7 0.0 1.4e-81 273.7 0.0 1.6 2 0 0 2 2 2 1 Kinesin motor domain HHH_3 PF12836.2 CCF32633.1 - 0.0001 22.1 0.2 0.0012 18.7 0.0 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH PF00633.18 CCF32633.1 - 0.072 12.8 0.0 6 6.7 0.0 2.9 2 0 0 2 2 2 0 Helix-hairpin-helix motif Methyltransf_32 PF13679.1 CCF32634.1 - 3.5e-18 65.6 0.0 6.9e-18 64.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Syntaxin-6_N PF09177.6 CCF32635.1 - 9.1e-26 90.1 0.1 4.6e-25 87.8 0.0 2.0 2 0 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.14 CCF32635.1 - 1e-13 50.7 8.1 3.1e-13 49.2 2.3 3.0 3 0 0 3 3 3 1 SNARE domain DUF869 PF05911.6 CCF32635.1 - 0.017 13.3 0.0 0.022 13.0 0.0 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) NPV_P10 PF05531.7 CCF32635.1 - 0.23 11.7 1.3 24 5.2 0.1 3.2 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein CK2S PF15011.1 CCF32635.1 - 0.23 11.2 4.2 0.98 9.1 0.6 2.5 2 1 1 3 3 3 0 Casein Kinase 2 substrate COG2 PF06148.6 CCF32635.1 - 0.23 11.3 3.0 7.4 6.4 0.0 3.1 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1470 PF07336.6 CCF32635.1 - 0.28 11.5 2.8 2.9 8.2 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1470) Vps5 PF09325.5 CCF32635.1 - 0.33 10.1 4.0 0.78 8.9 0.1 2.8 3 0 0 3 3 3 0 Vps5 C terminal like GLE1 PF07817.8 CCF32636.1 - 5.9e-25 87.6 0.0 4.2e-24 84.8 0.0 2.2 2 1 0 2 2 2 1 GLE1-like protein Arrestin_C PF02752.17 CCF32637.1 - 7e-16 58.5 0.1 1.4e-14 54.3 0.1 2.1 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Trs65 PF12735.2 CCF32637.1 - 0.024 13.9 0.2 0.11 11.8 0.1 1.9 1 1 1 2 2 2 0 TRAPP trafficking subunit Trs65 adh_short PF00106.20 CCF32638.1 - 5.1e-14 52.5 0.2 1e-13 51.5 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase Epimerase PF01370.16 CCF32638.1 - 0.00043 19.7 0.0 0.00062 19.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.5 CCF32638.1 - 0.0013 18.4 0.0 0.0023 17.6 0.0 1.4 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF32638.1 - 0.04 13.6 0.0 0.052 13.3 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase p450 PF00067.17 CCF32640.1 - 5.8e-76 255.8 0.0 7.3e-76 255.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 YjgP_YjgQ PF03739.9 CCF32640.1 - 0.16 10.6 1.0 0.26 9.9 0.7 1.2 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family DUF3074 PF11274.3 CCF32641.1 - 7.3e-42 143.0 0.1 1.1e-41 142.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) IncA PF04156.9 CCF32642.1 - 0.0058 16.2 2.9 0.0088 15.6 2.0 1.3 1 0 0 1 1 1 1 IncA protein Allexi_40kDa PF05549.6 CCF32642.1 - 0.45 9.7 2.4 0.78 8.9 0.6 1.9 1 1 1 2 2 2 0 Allexivirus 40kDa protein TMF_DNA_bd PF12329.3 CCF32642.1 - 1.8 8.4 5.5 0.91 9.3 1.1 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Glutaredoxin PF00462.19 CCF32643.1 - 2e-18 66.1 0.0 3.1e-17 62.2 0.0 2.3 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.15 CCF32643.1 - 1.9e-14 53.1 0.0 4.3e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 CCF32643.1 - 0.01 15.9 0.0 3.9 7.6 0.0 2.5 1 1 1 2 2 2 0 Thioredoxin-like HyaE PF07449.6 CCF32643.1 - 0.02 14.8 0.0 0.072 12.9 0.0 1.9 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_2 PF13098.1 CCF32643.1 - 0.034 14.3 0.0 0.7 10.1 0.0 2.8 2 2 1 3 3 3 0 Thioredoxin-like domain Thioredoxin_3 PF13192.1 CCF32643.1 - 0.12 12.2 0.0 0.55 10.0 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin domain Zds_C PF08632.5 CCF32644.1 - 5.8e-29 99.2 0.9 1.1e-28 98.3 0.7 1.5 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term DUF2433 PF10360.4 CCF32645.1 - 1.9e-55 186.7 0.0 3.4e-55 185.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) DUF2360 PF10152.4 CCF32645.1 - 7.9e-05 22.9 2.8 0.00023 21.4 2.0 1.8 1 1 0 1 1 1 1 Predicted coiled-coil domain-containing protein (DUF2360) Metallophos PF00149.23 CCF32645.1 - 0.016 14.5 0.0 0.035 13.5 0.0 1.6 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CCF32645.1 - 0.021 14.6 0.0 0.048 13.4 0.0 1.7 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain PRCC PF10253.4 CCF32645.1 - 0.16 12.6 1.7 0.4 11.3 1.2 1.6 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF605 PF04652.11 CCF32645.1 - 6.2 6.1 17.1 10 5.3 11.8 1.3 1 0 0 1 1 1 0 Vta1 like Ubie_methyltran PF01209.13 CCF32646.1 - 1.2e-79 266.6 0.0 2.9e-79 265.4 0.0 1.5 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 CCF32646.1 - 1.2e-13 51.3 0.0 3.9e-13 49.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF32646.1 - 2.2e-13 50.0 0.0 3.1e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF32646.1 - 1.4e-12 47.9 0.0 2.3e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF32646.1 - 7.4e-11 42.3 0.0 1.2e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF32646.1 - 1.2e-10 41.3 0.0 1.8e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF32646.1 - 2.2e-08 34.6 0.0 4.1e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF32646.1 - 7.1e-05 22.8 0.0 0.00025 21.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 CCF32646.1 - 0.0057 16.3 0.0 0.027 14.0 0.0 2.1 3 0 0 3 3 3 1 Hypothetical methyltransferase Aminotran_4 PF01063.14 CCF32648.1 - 2.4e-34 118.7 0.0 3.3e-34 118.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class IV MFS_1 PF07690.11 CCF32649.1 - 2.6e-33 115.1 26.9 2.6e-33 115.1 18.7 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily EIIBC-GUT_C PF07663.6 CCF32649.1 - 0.0092 16.0 0.6 0.039 14.0 0.0 2.3 2 0 0 2 2 2 1 Sorbitol phosphotransferase enzyme II C-terminus DSRB PF10781.4 CCF32649.1 - 0.0093 15.4 0.4 0.028 13.9 0.0 1.9 2 0 0 2 2 2 1 Dextransucrase DSRB PAS_3 PF08447.6 CCF32652.1 - 1.5e-12 47.4 0.0 3.6e-12 46.1 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.1 CCF32652.1 - 9.7e-11 41.9 0.0 2.3e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS PF00989.19 CCF32652.1 - 1.2e-07 31.5 0.1 4.9e-07 29.5 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.1 CCF32652.1 - 3.8e-05 23.6 0.0 0.00017 21.5 0.0 1.9 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.5 CCF32652.1 - 0.0015 18.5 0.0 0.0029 17.6 0.0 1.5 1 0 0 1 1 1 1 PAS fold DUF4428 PF14471.1 CCF32652.1 - 0.03 14.0 1.7 0.099 12.3 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) AAA_23 PF13476.1 CCF32653.1 - 9e-28 97.9 0.5 9e-28 97.9 0.3 4.3 1 1 1 2 2 1 1 AAA domain SMC_N PF02463.14 CCF32653.1 - 3.2e-09 36.3 0.1 3.2e-09 36.3 0.1 2.3 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_13 PF13166.1 CCF32653.1 - 0.00047 18.7 0.1 0.00047 18.7 0.1 4.0 2 1 2 4 4 4 2 AAA domain AAA_29 PF13555.1 CCF32653.1 - 0.001 18.5 0.0 0.0022 17.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.1 CCF32653.1 - 0.0049 16.8 1.2 0.018 14.9 0.8 2.2 1 1 0 1 1 1 1 AAA domain MobB PF03205.9 CCF32653.1 - 0.0089 15.7 0.3 0.12 12.0 0.0 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.22 CCF32653.1 - 0.043 14.1 0.0 0.043 14.1 0.0 3.9 2 1 0 2 2 1 0 ABC transporter AAA_22 PF13401.1 CCF32653.1 - 0.1 12.7 0.1 0.1 12.7 0.1 3.4 3 2 1 4 4 4 0 AAA domain AAA_16 PF13191.1 CCF32653.1 - 0.1 12.5 0.0 0.1 12.5 0.0 3.8 2 1 0 2 2 1 0 AAA ATPase domain DUF948 PF06103.6 CCF32653.1 - 0.33 10.8 20.7 1 9.2 0.3 5.7 5 1 0 5 5 5 0 Bacterial protein of unknown function (DUF948) AAA_33 PF13671.1 CCF32653.1 - 1 9.2 0.0 1 9.2 0.0 3.7 4 1 0 4 4 4 0 AAA domain AAA_15 PF13175.1 CCF32653.1 - 2 7.3 29.6 0.85 8.5 15.9 2.8 1 1 1 2 2 2 0 AAA ATPase domain Strep_SA_rep PF06696.6 CCF32653.1 - 4.3 7.2 12.6 16 5.4 1.7 4.3 3 0 0 3 3 3 0 Streptococcal surface antigen repeat Reo_sigmaC PF04582.7 CCF32653.1 - 5.2 6.1 8.7 0.61 9.2 0.3 3.0 3 1 0 3 3 3 0 Reovirus sigma C capsid protein DUF1754 PF08555.5 CCF32656.1 - 2.3e-10 40.9 21.4 6.5e-09 36.2 14.8 2.3 1 1 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) AA_permease_2 PF13520.1 CCF32657.1 - 2.6e-62 210.7 41.8 3.4e-62 210.3 29.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF32657.1 - 2.2e-28 98.8 41.9 8e-28 97.0 29.1 1.8 1 1 0 1 1 1 1 Amino acid permease DUF4405 PF14358.1 CCF32657.1 - 0.084 13.0 0.4 0.084 13.0 0.3 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4405) 2-Hacid_dh_C PF02826.14 CCF32658.1 - 8e-53 178.2 0.0 9.3e-53 177.9 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.10 CCF32658.1 - 5.1e-05 23.1 0.0 8.9e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.7 CCF32658.1 - 0.093 12.0 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain FAD_binding_3 PF01494.14 CCF32661.1 - 4.4e-75 252.9 0.0 5.8e-75 252.5 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.7 CCF32661.1 - 2.1e-43 147.8 0.0 3.9e-43 146.9 0.0 1.5 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox PF00070.22 CCF32661.1 - 3.2e-05 24.2 0.0 0.001 19.4 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase XdhC_C PF13478.1 CCF32661.1 - 0.0056 16.9 0.0 0.015 15.6 0.0 1.7 1 0 0 1 1 1 1 XdhC Rossmann domain Thi4 PF01946.12 CCF32661.1 - 0.0061 15.6 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.9 CCF32661.1 - 0.0099 15.7 0.0 0.029 14.2 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF32661.1 - 0.013 14.4 0.0 0.081 11.8 0.0 2.2 3 0 0 3 3 3 0 Lycopene cyclase protein DAO PF01266.19 CCF32661.1 - 0.037 12.9 0.0 0.6 8.9 0.0 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF32661.1 - 0.038 14.0 0.0 0.098 12.6 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 CCF32661.1 - 0.04 12.4 0.0 0.074 11.5 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein GDI PF00996.13 CCF32661.1 - 0.18 10.0 0.0 0.3 9.3 0.0 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor CAP_N PF01213.14 CCF32662.1 - 0.11 11.7 1.6 0.15 11.3 1.1 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal WSC PF01822.14 CCF32663.1 - 2.1e-17 62.8 6.7 2.7e-17 62.4 4.7 1.2 1 0 0 1 1 1 1 WSC domain IMS PF00817.15 CCF32664.1 - 1.4e-39 135.3 0.0 2.7e-39 134.3 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 CCF32664.1 - 3.4e-18 65.8 0.0 9e-18 64.4 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain DUF4414 PF14377.1 CCF32664.1 - 6e-12 45.4 10.1 6.4e-07 29.2 1.0 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF4414) HHH_5 PF14520.1 CCF32664.1 - 0.0014 18.7 0.0 0.0073 16.4 0.0 2.2 1 0 0 1 1 1 1 Helix-hairpin-helix domain IMS_HHH PF11798.3 CCF32664.1 - 0.0038 17.1 1.5 0.013 15.5 0.0 2.7 3 0 0 3 3 3 1 IMS family HHH motif DUF1805 PF08827.6 CCF32664.1 - 0.012 15.3 0.0 0.26 11.1 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1805) MgtE_N PF03448.12 CCF32664.1 - 0.035 14.4 0.1 3.1 8.1 0.0 3.1 2 0 0 2 2 2 0 MgtE intracellular N domain RED_N PF07808.8 CCF32665.1 - 2.3e-13 49.9 3.3 3.1e-13 49.5 2.3 1.2 1 0 0 1 1 1 1 RED-like protein N-terminal region DUF4607 PF15380.1 CCF32665.1 - 0.0086 15.5 1.6 0.01 15.3 1.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4607) INO80_Ies4 PF08193.6 CCF32665.1 - 0.08 12.8 5.8 0.12 12.3 4.0 1.3 1 0 0 1 1 1 0 INO80 complex subunit Ies4 Abhydrolase_6 PF12697.2 CCF32667.1 - 4.8e-23 82.2 0.1 6e-23 81.9 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF32667.1 - 1.3e-10 41.1 0.0 3.6e-10 39.7 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CCF32667.1 - 9.9e-07 28.5 0.0 2.1e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_1 PF00561.15 CCF32667.1 - 1.1e-06 28.3 0.0 1.4e-06 28.0 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Lipase_3 PF01764.20 CCF32667.1 - 0.0097 15.5 0.0 0.024 14.2 0.0 1.7 2 0 0 2 2 2 1 Lipase (class 3) DLH PF01738.13 CCF32667.1 - 0.01 15.1 0.0 0.11 11.7 0.0 2.4 2 1 0 2 2 2 0 Dienelactone hydrolase family tRNA-synt_2d PF01409.15 CCF32669.1 - 6.3e-49 166.4 0.2 6.3e-25 87.8 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.9 CCF32669.1 - 9.3e-25 86.6 0.0 1.9e-24 85.6 0.0 1.5 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain TFIIIC_delta PF12657.2 CCF32670.1 - 0.16 11.6 0.2 0.18 11.4 0.1 1.1 1 0 0 1 1 1 0 Transcription factor IIIC subunit delta N-term Calcipressin PF04847.7 CCF32671.1 - 2.7e-51 173.7 0.1 3.2e-51 173.5 0.1 1.1 1 0 0 1 1 1 1 Calcipressin MFS_1 PF07690.11 CCF32674.1 - 2.6e-30 105.3 34.3 3.3e-19 68.8 8.6 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily DUF4187 PF13821.1 CCF32675.1 - 1.1e-19 69.7 5.4 3.9e-19 68.0 3.7 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) Hex_IIIa PF02455.11 CCF32675.1 - 0.77 8.3 8.1 0.98 8.0 5.6 1.2 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) BTV_NS2 PF04514.7 CCF32675.1 - 1.2 7.8 19.0 1.6 7.4 13.2 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 DUF4484 PF14831.1 CCF32675.1 - 5.4 7.0 7.9 11 6.1 5.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4484) PPR_2 PF13041.1 CCF32676.1 - 1.8e-12 46.9 0.0 4.6e-06 26.5 0.0 4.7 4 0 0 4 4 4 3 PPR repeat family PPR PF01535.15 CCF32676.1 - 3.3e-06 26.7 0.1 0.23 11.4 0.0 4.7 4 0 0 4 4 4 2 PPR repeat PPR_3 PF13812.1 CCF32676.1 - 2.3e-05 24.2 2.6 15 6.2 0.0 6.7 7 0 0 7 7 7 1 Pentatricopeptide repeat domain PPR_1 PF12854.2 CCF32676.1 - 0.0023 17.3 0.1 3.2 7.3 0.0 3.6 4 0 0 4 4 4 2 PPR repeat TPR_14 PF13428.1 CCF32676.1 - 0.018 15.6 4.1 3.1 8.7 0.0 5.3 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.1 CCF32676.1 - 0.12 13.1 1.5 12 6.6 0.2 3.4 2 1 0 2 2 2 0 Tetratricopeptide repeat RTC PF01137.16 CCF32677.1 - 3e-30 104.7 0.1 3.9e-30 104.3 0.1 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.8 CCF32677.1 - 6.2e-30 103.2 0.1 1.1e-29 102.4 0.0 1.5 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain tRNA-synt_2d PF01409.15 CCF32679.1 - 6.6e-86 287.5 0.0 9.1e-86 287.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.15 CCF32679.1 - 6.3e-06 25.1 4.8 0.00011 21.1 0.1 3.7 3 1 1 4 4 4 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.20 CCF32679.1 - 0.0002 21.0 0.0 0.0005 19.6 0.0 1.7 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) MFS_1 PF07690.11 CCF32680.1 - 3.7e-33 114.7 60.5 1.5e-24 86.3 27.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pex14_N PF04695.8 CCF32680.1 - 0.096 12.7 1.2 0.18 11.8 0.8 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Glyco_hydro_67M PF07488.7 CCF32681.1 - 3e-143 476.6 0.0 4e-143 476.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 middle domain Glyco_hydro_67C PF07477.7 CCF32681.1 - 1.1e-94 316.0 1.9 1.6e-94 315.5 1.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 C-terminus Glyco_hydro_67N PF03648.9 CCF32681.1 - 8.6e-25 87.1 0.0 1.5e-24 86.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 N-terminus Glyco_hydro_20b PF02838.10 CCF32681.1 - 0.0079 16.7 0.1 0.023 15.2 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Ribul_P_3_epim PF00834.14 CCF32681.1 - 0.13 11.3 0.0 0.28 10.2 0.0 1.5 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family Methyltransf_26 PF13659.1 CCF32682.1 - 1.2e-17 63.9 0.1 1.6e-17 63.5 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF32682.1 - 0.00034 20.0 0.0 0.00057 19.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 CCF32682.1 - 0.078 13.3 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain LSM PF01423.17 CCF32683.1 - 1.2e-16 60.0 0.0 1.5e-16 59.6 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 CCF32683.1 - 0.0002 21.1 0.0 0.0003 20.6 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF2763 PF10961.3 CCF32683.1 - 0.14 12.5 6.4 0.22 11.9 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2763) Tyrosinase PF00264.15 CCF32684.1 - 1.6e-50 172.3 2.4 3.1e-50 171.4 1.7 1.5 1 0 0 1 1 1 1 Common central domain of tyrosinase RNA_pol_Rpb2_6 PF00562.23 CCF32685.1 - 7.6e-113 377.1 0.0 9.9e-113 376.7 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 CCF32685.1 - 2.2e-31 108.3 0.0 3e-31 107.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 CCF32685.1 - 7.2e-26 90.7 0.0 1.2e-25 90.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.11 CCF32685.1 - 4.6e-25 87.1 0.0 1.2e-24 85.8 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.7 CCF32685.1 - 4e-23 81.1 0.0 8.5e-23 80.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.15 CCF32685.1 - 1.9e-14 53.6 0.0 1.1e-13 51.2 0.0 2.2 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_5 PF04567.12 CCF32685.1 - 0.011 15.6 0.2 0.025 14.5 0.1 1.7 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 5 Rpr2 PF04032.11 CCF32685.1 - 0.073 12.9 0.7 0.15 11.9 0.5 1.5 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain DZR PF12773.2 CCF32685.1 - 0.29 10.9 1.2 0.62 9.9 0.8 1.4 1 0 0 1 1 1 0 Double zinc ribbon zf-rbx1 PF12678.2 CCF32686.1 - 1.3e-12 47.6 1.2 1.9e-12 47.1 0.9 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 CCF32686.1 - 0.00025 20.8 1.2 0.00034 20.4 0.8 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger PNRC PF15365.1 CCF32688.1 - 6.3e-08 32.5 12.6 2.2e-05 24.3 5.4 3.4 2 0 0 2 2 2 2 Proline-rich nuclear receptor coactivator DUF320 PF03777.8 CCF32688.1 - 0.78 9.5 4.1 12 5.7 0.1 2.9 2 0 0 2 2 2 0 Small secreted domain (DUF320) Tyr-DNA_phospho PF06087.7 CCF32689.1 - 4.7e-74 249.6 0.0 6.6e-74 249.1 0.0 1.3 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.1 CCF32689.1 - 6.9e-05 22.5 0.0 0.0017 18.0 0.0 2.3 2 0 0 2 2 2 1 PLD-like domain UIM PF02809.15 CCF32689.1 - 0.00018 20.7 2.8 0.00018 20.7 1.9 2.2 2 0 0 2 2 2 1 Ubiquitin interaction motif p450 PF00067.17 CCF32690.1 - 3.5e-18 65.3 0.0 3.7e-18 65.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NST1 PF13945.1 CCF32691.1 - 0.31 11.0 7.6 0.36 10.8 5.2 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator TFIIF_alpha PF05793.7 CCF32691.1 - 0.76 8.0 11.6 0.85 7.9 8.1 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BLVR PF06375.6 CCF32691.1 - 1.8 8.3 10.2 1.9 8.2 7.1 1.2 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) DUF755 PF05501.6 CCF32691.1 - 8.6 6.4 15.0 12 5.9 10.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF755) RNA_pol_Rpb4 PF03874.11 CCF32692.1 - 4.9e-28 97.4 5.0 6e-28 97.1 3.5 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 DUF2312 PF10073.4 CCF32692.1 - 0.24 10.7 1.2 1.3 8.4 0.1 2.3 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) CPL PF08144.6 CCF32694.1 - 1e-24 87.0 0.4 1.3e-23 83.5 0.0 2.9 4 0 0 4 4 4 1 CPL (NUC119) domain TraH_2 PF06871.6 CCF32694.1 - 0.091 12.1 0.2 0.091 12.1 0.1 2.0 2 0 0 2 2 2 0 TraH_2 PAP_central PF04928.12 CCF32694.1 - 1.6 7.4 5.7 1.1 8.0 0.6 2.7 2 1 0 2 2 2 0 Poly(A) polymerase central domain RWD PF05773.17 CCF32695.1 - 3.6e-23 81.6 0.4 3.6e-23 81.6 0.3 1.6 2 0 0 2 2 2 1 RWD domain GN3L_Grn1 PF08701.6 CCF32695.1 - 0.48 10.3 12.4 1.1 9.2 1.0 3.1 3 0 0 3 3 3 0 GNL3L/Grn1 putative GTPase DUF3886 PF13025.1 CCF32695.1 - 1.3 9.0 17.5 0.5 10.3 3.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) TPR_16 PF13432.1 CCF32696.1 - 1.6e-05 25.4 4.9 0.046 14.4 0.2 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 CCF32696.1 - 0.00048 20.5 4.6 1.3 9.8 0.0 4.1 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.1 CCF32696.1 - 0.00049 19.9 0.2 0.098 12.6 0.0 3.0 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 CCF32696.1 - 0.0021 18.3 3.2 1.4 9.2 0.5 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 CCF32696.1 - 0.0022 17.6 0.0 0.0077 15.8 0.0 2.0 2 0 0 2 2 2 1 TPR repeat Med9 PF07544.8 CCF32696.1 - 0.042 13.5 0.0 0.14 11.9 0.0 1.9 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 TPR_2 PF07719.12 CCF32696.1 - 0.29 11.1 4.5 0.54 10.2 0.0 3.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Cyt-b5 PF00173.23 CCF32697.1 - 1.2e-20 73.1 0.1 1.3e-20 72.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Kelch_2 PF07646.10 CCF32697.1 - 0.083 12.6 0.4 0.12 12.1 0.3 1.3 1 0 0 1 1 1 0 Kelch motif p450 PF00067.17 CCF32698.1 - 7.6e-70 235.7 0.0 9.5e-70 235.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 CorA PF01544.13 CCF32699.1 - 8.1e-10 38.2 0.0 1.1e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein efThoc1 PF11957.3 CCF32700.1 - 6.7e-117 390.9 4.7 1e-116 390.3 3.2 1.2 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Guanylate_kin PF00625.16 CCF32700.1 - 1.1e-29 103.1 0.0 2.7e-29 101.9 0.0 1.7 1 1 0 1 1 1 1 Guanylate kinase AAA_18 PF13238.1 CCF32700.1 - 0.0017 18.6 0.0 0.0072 16.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CCF32700.1 - 0.0059 16.4 0.0 0.069 13.0 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 CCF32700.1 - 0.017 15.0 0.0 0.13 12.1 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA_17 PF13207.1 CCF32700.1 - 0.021 15.6 1.3 0.06 14.1 0.1 2.5 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.1 CCF32700.1 - 0.081 12.6 0.1 0.31 10.8 0.0 2.0 2 0 0 2 2 2 0 Part of AAA domain DUF1220 PF06758.8 CCF32700.1 - 0.46 10.3 6.5 0.32 10.8 3.1 1.8 2 0 0 2 2 2 0 Repeat of unknown function (DUF1220) Cellulase PF00150.13 CCF32701.1 - 1.2e-15 57.4 0.0 3e-15 56.1 0.0 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) PH PF00169.24 CCF32702.1 - 5.9e-25 87.4 1.7 5.4e-15 55.4 0.1 2.2 2 0 0 2 2 2 2 PH domain PH_11 PF15413.1 CCF32702.1 - 1.1e-09 38.5 6.3 4.7e-06 26.8 0.2 3.6 2 2 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.1 CCF32702.1 - 7e-08 32.6 1.9 3.1e-05 24.1 0.3 3.5 2 2 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.1 CCF32702.1 - 0.00015 21.7 0.2 0.00033 20.6 0.2 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.1 CCF32702.1 - 0.0085 15.9 1.3 0.023 14.5 0.2 2.3 2 2 1 3 3 3 1 PH domain Mog1 PF04603.7 CCF32702.1 - 0.1 12.5 0.0 1 9.3 0.0 2.1 2 0 0 2 2 2 0 Ran-interacting Mog1 protein Arc PF03869.9 CCF32704.1 - 0.027 14.0 2.9 2.7 7.7 0.0 3.0 2 0 0 2 2 2 0 Arc-like DNA binding domain Lip_prot_lig_C PF10437.4 CCF32704.1 - 0.052 13.2 1.3 6.3 6.5 0.1 3.4 3 0 0 3 3 3 0 Bacterial lipoate protein ligase C-terminus DUF3142 PF11340.3 CCF32704.1 - 0.42 10.2 6.8 0.69 9.5 0.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3142) Metallophos_2 PF12850.2 CCF32705.1 - 4.8e-07 29.7 0.0 5.9e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 CCF32705.1 - 0.00017 21.0 0.0 0.00027 20.3 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Chitin_synth_1 PF01644.12 CCF32707.1 - 4.9e-81 270.3 0.5 7.4e-81 269.7 0.4 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 CCF32707.1 - 1.3e-31 108.1 0.1 3.7e-31 106.6 0.0 1.8 2 0 0 2 2 2 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 CCF32707.1 - 1.1e-22 80.2 3.1 6.4e-18 64.4 0.0 2.5 3 0 0 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.1 CCF32707.1 - 1.7e-07 31.1 8.7 1.7e-07 31.1 6.0 2.5 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 CCF32707.1 - 2.2e-06 27.6 0.0 8.4e-06 25.7 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 IGR PF09597.5 CCF32708.1 - 0.11 12.3 0.4 0.66 9.9 0.3 2.1 1 1 1 2 2 2 0 IGR protein motif DUF4611 PF15387.1 CCF32708.1 - 3.1 8.0 5.9 0.9 9.7 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) WCCH PF03716.9 CCF32710.1 - 0.064 12.7 3.0 0.11 11.9 2.1 1.3 1 0 0 1 1 1 0 WCCH motif p450 PF00067.17 CCF32711.1 - 8.3e-66 222.3 0.0 1e-65 222.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 AA_permease PF00324.16 CCF32712.1 - 2.2e-115 385.7 42.8 2.5e-115 385.5 29.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF32712.1 - 9.7e-37 126.4 49.3 1.4e-36 126.0 34.1 1.1 1 0 0 1 1 1 1 Amino acid permease DUF2101 PF09874.4 CCF32712.1 - 0.024 14.1 0.1 0.064 12.7 0.1 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2101) Med1 PF10744.4 CCF32713.1 - 1.5e-40 139.2 0.0 3e-40 138.1 0.0 1.5 1 1 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 Ribosomal_S3Ae PF01015.13 CCF32714.1 - 3.9e-16 58.9 0.4 4.8e-16 58.6 0.3 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydrolase_6 PF12697.2 CCF32715.1 - 7.4e-18 65.2 0.0 9.4e-18 64.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF32715.1 - 9.2e-16 58.0 0.0 7.6e-15 55.0 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF32715.1 - 1.1e-05 25.2 0.0 1.9e-05 24.4 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 CCF32715.1 - 0.00027 20.4 0.0 0.00034 20.1 0.0 1.2 1 0 0 1 1 1 1 Putative esterase PGAP1 PF07819.8 CCF32715.1 - 0.01 15.4 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Ndr PF03096.9 CCF32715.1 - 0.048 12.1 0.0 0.069 11.6 0.0 1.2 1 0 0 1 1 1 0 Ndr family DUF2048 PF09752.4 CCF32715.1 - 0.075 11.8 0.0 0.11 11.3 0.0 1.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) Bromodomain PF00439.20 CCF32720.1 - 4.7e-10 39.2 0.0 1e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Bromodomain FimP PF09766.4 CCF32720.1 - 0.072 12.1 10.7 0.13 11.3 7.4 1.3 1 0 0 1 1 1 0 Fms-interacting protein DASH_Dad1 PF08649.5 CCF32722.1 - 3.7e-24 84.1 1.3 4.7e-24 83.8 0.9 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad1 WVELL PF14043.1 CCF32722.1 - 0.091 12.3 0.1 0.15 11.6 0.1 1.5 1 1 0 1 1 1 0 WVELL protein ATP-synt_E_2 PF08112.6 CCF32722.1 - 0.13 12.3 0.1 0.21 11.6 0.1 1.3 1 0 0 1 1 1 0 ATP synthase epsilon subunit PB1-F2 PF11986.3 CCF32723.1 - 0.047 13.7 0.2 0.14 12.2 0.1 1.7 1 0 0 1 1 1 0 Influenza A Proapoptotic protein DASH_Dam1 PF08653.5 CCF32723.1 - 0.14 11.9 0.1 16 5.3 0.0 3.2 3 0 0 3 3 3 0 DASH complex subunit Dam1 RNA_pol_Rpb5_C PF01191.14 CCF32725.1 - 1.2e-35 120.8 0.4 1.9e-35 120.3 0.3 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain DAO PF01266.19 CCF32726.1 - 4e-16 58.8 3.4 2.7e-14 52.8 2.4 2.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.19 CCF32726.1 - 6.1e-15 55.2 0.2 1.2e-14 54.2 0.0 1.7 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 CCF32726.1 - 5.7e-14 51.8 0.1 1.5e-13 50.5 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CCF32726.1 - 3.3e-08 32.7 2.3 1.7e-05 23.8 1.1 2.2 2 0 0 2 2 2 2 FAD binding domain HI0933_like PF03486.9 CCF32726.1 - 1e-07 30.7 0.3 0.0017 16.9 0.6 2.1 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_3 PF13738.1 CCF32726.1 - 2.3e-06 27.8 0.0 0.00047 20.2 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 CCF32726.1 - 2.9e-06 26.6 0.0 0.00039 19.6 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF32726.1 - 3.7e-05 23.6 0.0 0.00012 22.0 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF32726.1 - 0.002 18.4 2.1 0.071 13.5 0.7 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF32726.1 - 0.005 15.9 0.1 0.0088 15.1 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.14 CCF32726.1 - 0.0063 15.6 0.7 0.011 14.8 0.5 1.3 1 0 0 1 1 1 1 FAD binding domain ApbA PF02558.11 CCF32726.1 - 0.036 13.5 0.7 0.071 12.5 0.5 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.7 CCF32726.1 - 0.037 12.9 2.5 0.045 12.6 0.4 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein GMC_oxred_N PF00732.14 CCF32726.1 - 0.042 13.0 0.3 1.7 7.6 0.0 2.2 2 0 0 2 2 2 0 GMC oxidoreductase NAD_binding_9 PF13454.1 CCF32726.1 - 0.046 13.4 2.5 0.19 11.5 0.1 2.7 3 0 0 3 3 3 0 FAD-NAD(P)-binding Trp_halogenase PF04820.9 CCF32726.1 - 0.054 12.1 0.4 5 5.6 0.0 2.4 2 0 0 2 2 2 0 Tryptophan halogenase 3HCDH_N PF02737.13 CCF32726.1 - 0.076 12.6 0.8 0.13 11.9 0.5 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.18 CCF32726.1 - 0.12 12.1 0.4 0.24 11.0 0.1 1.6 2 0 0 2 2 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GIDA PF01134.17 CCF32726.1 - 0.13 11.1 3.0 0.18 10.6 1.3 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A XdhC_C PF13478.1 CCF32726.1 - 0.13 12.5 0.1 1.1 9.5 0.0 2.2 2 0 0 2 2 2 0 XdhC Rossmann domain DASH_Hsk3 PF08227.6 CCF32727.1 - 1.4e-20 73.1 3.0 1.9e-20 72.7 2.1 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like BBS2_C PF14782.1 CCF32727.1 - 0.042 12.4 0.0 0.045 12.3 0.0 1.0 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal ApbA_C PF08546.6 CCF32729.1 - 9.3e-24 83.8 0.0 1.4e-23 83.2 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 CCF32729.1 - 4.9e-23 81.2 0.0 7.4e-23 80.6 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA SPRY PF00622.23 CCF32730.1 - 2e-28 98.9 0.2 3.4e-28 98.2 0.1 1.4 1 0 0 1 1 1 1 SPRY domain CLTH PF10607.4 CCF32730.1 - 1.6e-27 96.0 0.2 3e-27 95.1 0.1 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.6 CCF32730.1 - 6e-06 25.8 0.5 1.3e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 LisH INO80_Ies4 PF08193.6 CCF32732.1 - 5.9e-65 219.3 22.2 1.2e-64 218.3 15.4 1.5 1 1 0 1 1 1 1 INO80 complex subunit Ies4 ketoacyl-synt PF00109.21 CCF32733.1 - 2.9e-72 243.1 0.1 1.7e-71 240.6 0.0 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 CCF32733.1 - 2e-46 158.7 0.0 2.9e-46 158.2 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.17 CCF32733.1 - 4.3e-41 139.4 0.1 9.5e-41 138.3 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.1 CCF32733.1 - 2.9e-36 125.1 0.0 1.5e-35 122.7 0.0 1.9 2 0 0 2 2 2 1 Polyketide synthase dehydratase Thiolase_N PF00108.18 CCF32733.1 - 0.00051 19.1 0.0 0.0011 18.0 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 CCF32733.1 - 0.025 14.2 0.1 0.063 12.9 0.1 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III p450 PF00067.17 CCF32734.1 - 5.5e-51 173.5 0.0 7.8e-51 173.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 UPF0542 PF15086.1 CCF32734.1 - 0.14 11.9 0.8 0.29 10.8 0.5 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 Pol_alpha_B_N PF08418.5 CCF32735.1 - 0.23 10.9 7.8 0.45 10.0 5.4 1.4 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal CHASE3 PF05227.8 CCF32735.1 - 1.1 8.9 6.1 1.3 8.6 0.1 3.1 4 0 0 4 4 4 0 CHASE3 domain Actin PF00022.14 CCF32736.1 - 1e-140 468.6 0.0 1.2e-140 468.4 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 CCF32736.1 - 0.024 15.0 0.0 0.074 13.4 0.0 1.8 1 1 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) RF-1 PF00472.15 CCF32737.1 - 7.3e-27 93.4 2.8 9.8e-27 93.0 1.9 1.1 1 0 0 1 1 1 1 RF-1 domain DUF3317 PF11779.3 CCF32738.1 - 4.1e-17 61.3 5.8 5.5e-17 60.9 4.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3317) Ion_trans_N PF08412.5 CCF32738.1 - 0.054 12.8 1.3 0.08 12.2 0.9 1.2 1 0 0 1 1 1 0 Ion transport protein N-terminal Pex24p PF06398.6 CCF32738.1 - 0.21 10.3 1.3 0.21 10.3 0.9 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Cytochrome-c551 PF10643.4 CCF32738.1 - 0.26 10.5 2.7 0.33 10.2 1.8 1.3 1 1 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 WD40 PF00400.27 CCF32739.1 - 1.4e-57 189.6 13.1 2.2e-07 30.4 0.0 11.2 12 0 0 12 12 12 9 WD domain, G-beta repeat BBS2_Mid PF14783.1 CCF32739.1 - 0.0083 15.8 0.0 2.2 8.1 0.0 4.4 5 1 0 5 5 5 1 Ciliary BBSome complex subunit 2, middle region Nucleoporin_N PF08801.6 CCF32739.1 - 0.19 10.4 0.0 2.2 6.9 0.0 2.6 2 1 0 2 2 2 0 Nup133 N terminal like Urm1 PF09138.6 CCF32740.1 - 7.7e-33 112.4 0.0 9e-33 112.2 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.15 CCF32740.1 - 0.00079 19.8 0.1 0.0015 18.9 0.0 1.5 2 0 0 2 2 2 1 ThiS family NAD_kinase PF01513.16 CCF32743.1 - 3.8e-73 245.7 0.0 5e-73 245.3 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase Homeobox PF00046.24 CCF32745.1 - 1.2e-13 50.4 1.6 1.5e-13 50.1 0.4 1.7 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.6 CCF32745.1 - 0.03 14.0 0.1 0.068 12.8 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain MCPVI PF02993.9 CCF32745.1 - 4.9 7.2 7.8 1 9.4 0.2 2.0 2 0 0 2 2 2 0 Minor capsid protein VI Pkinase PF00069.20 CCF32747.1 - 5.7e-09 35.4 0.0 6.6e-06 25.4 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CCF32747.1 - 4.7e-07 29.1 0.0 0.0017 17.5 0.0 3.6 2 1 0 2 2 2 2 Protein tyrosine kinase DUF605 PF04652.11 CCF32747.1 - 4.5 6.5 20.1 0.57 9.5 10.9 1.7 2 0 0 2 2 2 0 Vta1 like Aldo_ket_red PF00248.16 CCF32748.1 - 2.5e-48 164.3 0.0 2.9e-48 164.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family LRR_4 PF12799.2 CCF32749.1 - 9.5e-41 136.8 25.0 2.6e-09 36.5 0.0 6.6 3 2 2 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CCF32749.1 - 2.4e-22 78.4 21.5 5.7e-09 35.6 0.2 4.8 2 2 3 5 5 5 5 Leucine rich repeat LRR_1 PF00560.28 CCF32749.1 - 9e-14 49.3 24.4 0.68 10.1 0.2 11.1 11 0 0 11 11 11 5 Leucine Rich Repeat LRR_6 PF13516.1 CCF32749.1 - 1.8e-12 45.9 21.4 0.17 12.0 0.2 10.6 9 2 2 11 11 11 4 Leucine Rich repeat LRR_7 PF13504.1 CCF32749.1 - 3.8e-11 41.2 13.9 1.1 9.7 0.0 9.8 10 0 0 10 10 10 3 Leucine rich repeat LRR_9 PF14580.1 CCF32749.1 - 6e-11 42.2 28.8 2.5e-05 23.8 1.2 3.6 1 1 5 6 6 6 5 Leucine-rich repeat Abhydrolase_5 PF12695.2 CCF32750.1 - 2.1e-11 43.7 0.0 3.2e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF32750.1 - 2.3e-11 44.0 2.7 4.2e-11 43.1 1.6 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 CCF32750.1 - 0.00053 19.6 0.1 0.0012 18.4 0.1 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.15 CCF32750.1 - 0.071 12.6 0.0 0.17 11.3 0.0 1.6 1 1 1 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF32750.1 - 0.084 12.0 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family BTB PF00651.26 CCF32751.1 - 9.3e-07 28.8 0.0 3.5e-06 26.9 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain PCI PF01399.22 CCF32752.1 - 5.1e-06 26.7 0.0 9e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 PCI domain Thiolase_N PF00108.18 CCF32753.1 - 3.5e-80 268.7 2.5 5.2e-80 268.2 1.7 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 CCF32753.1 - 1.9e-40 137.0 0.3 3.9e-40 136.1 0.2 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.5 CCF32753.1 - 0.0058 16.6 0.0 0.032 14.2 0.0 2.3 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal NMO PF03060.10 CCF32754.1 - 1.6e-60 205.0 0.1 2.4e-60 204.4 0.1 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 CCF32754.1 - 3.7e-11 42.5 0.0 1.6e-05 23.9 0.0 2.1 1 1 1 2 2 2 2 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 CCF32754.1 - 0.0024 16.7 0.2 0.0058 15.5 0.1 1.6 2 0 0 2 2 2 1 FMN-dependent dehydrogenase NIL PF09383.5 CCF32754.1 - 0.086 12.4 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 NIL domain GIDA PF01134.17 CCF32756.1 - 7.8e-154 512.2 0.0 1e-153 511.8 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc_3 PF13932.1 CCF32756.1 - 7.5e-15 54.7 1.6 4.5e-14 52.2 0.0 2.7 2 1 1 3 3 3 1 GidA associated domain 3 Pyr_redox_2 PF07992.9 CCF32756.1 - 0.0012 18.8 0.2 0.0032 17.3 0.1 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 CCF32756.1 - 0.0051 15.9 0.5 0.0098 15.0 0.3 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Sec1 PF00995.18 CCF32757.1 - 7e-153 510.2 0.0 8.1e-153 510.0 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DUF1204 PF06721.6 CCF32757.1 - 0.0083 15.4 0.0 0.38 9.9 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1204) DUF2404 PF10296.4 CCF32758.1 - 7.2e-07 29.2 0.0 1.5e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) Tn7_Tnp_TnsA_C PF08721.6 CCF32758.1 - 0.072 13.1 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 TnsA endonuclease C terminal DUF913 PF06025.7 CCF32759.1 - 5.9e-110 367.5 0.0 5.9e-110 367.5 0.0 3.4 4 0 0 4 4 4 1 Domain of Unknown Function (DUF913) DUF4414 PF14377.1 CCF32759.1 - 1.8e-32 111.4 7.9 1.8e-32 111.4 5.4 3.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4414) APG6 PF04111.7 CCF32761.1 - 9e-117 389.5 0.0 1.1e-116 389.2 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 Rpr2 PF04032.11 CCF32761.1 - 0.02 14.7 0.0 0.27 11.1 0.0 2.4 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF972 PF06156.8 CCF32761.1 - 0.14 12.5 1.3 0.3 11.4 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) IncA PF04156.9 CCF32761.1 - 0.24 10.9 8.6 0.43 10.1 5.9 1.3 1 0 0 1 1 1 0 IncA protein zf-C4H2 PF10146.4 CCF32761.1 - 0.4 10.6 6.4 0.89 9.5 4.4 1.6 1 0 0 1 1 1 0 Zinc finger-containing protein DUF4140 PF13600.1 CCF32761.1 - 0.95 9.9 7.6 1.4 9.3 4.4 2.1 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) V_ATPase_I PF01496.14 CCF32761.1 - 1.2 6.9 5.2 1.6 6.4 3.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4337 PF14235.1 CCF32761.1 - 8.8 6.1 8.8 16 5.3 6.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Scm3 PF10384.4 CCF32763.1 - 1.4e-20 72.5 0.2 3.8e-20 71.1 0.1 1.8 1 0 0 1 1 1 1 Centromere protein Scm3 MMR_HSR1 PF01926.18 CCF32765.1 - 4.9e-05 23.2 0.0 6.8e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 CCF32765.1 - 6.2e-05 22.8 0.0 0.31 10.8 0.0 2.3 2 0 0 2 2 2 2 Dynamin family Miro PF08477.8 CCF32765.1 - 0.015 15.7 0.0 0.034 14.6 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein ATP_bind_1 PF03029.12 CCF32765.1 - 0.023 14.2 0.0 0.11 11.9 0.0 2.0 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.1 CCF32765.1 - 0.026 14.6 0.0 0.093 12.8 0.0 1.9 2 1 0 2 2 2 0 AAA domain MobB PF03205.9 CCF32765.1 - 0.031 13.9 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_17 PF13207.1 CCF32765.1 - 0.07 13.9 0.0 0.16 12.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain Syntaxin_2 PF14523.1 CCF32765.1 - 0.093 12.7 0.1 0.15 12.1 0.1 1.2 1 0 0 1 1 1 0 Syntaxin-like protein AAA_33 PF13671.1 CCF32765.1 - 0.15 11.9 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Ank_2 PF12796.2 CCF32766.1 - 5.3e-11 42.6 0.0 3.2e-05 24.1 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 CCF32766.1 - 3.7e-10 39.1 0.2 1 9.2 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.1 CCF32766.1 - 2.7e-09 36.3 2.0 0.075 13.3 0.0 5.9 6 0 0 6 6 6 2 Ankyrin repeat Ank_4 PF13637.1 CCF32766.1 - 4.6e-06 26.9 0.2 20 5.8 0.0 5.7 6 0 0 6 6 6 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF32766.1 - 0.02 15.1 0.6 54 4.2 0.0 4.6 5 0 0 5 5 5 0 Ankyrin repeats (many copies) NdhL PF10716.4 CCF32768.1 - 0.065 13.0 0.7 0.065 13.0 0.5 2.3 2 1 0 2 2 2 0 NADH dehydrogenase transmembrane subunit Amastin PF07344.6 CCF32768.1 - 0.084 12.4 6.9 0.12 11.9 4.8 1.3 1 0 0 1 1 1 0 Amastin surface glycoprotein NPCC PF08058.6 CCF32768.1 - 0.2 11.5 4.8 0.46 10.3 2.6 1.9 1 1 1 2 2 2 0 Nuclear pore complex component CENP-T PF15511.1 CCF32770.1 - 0.051 12.8 1.1 0.061 12.5 0.7 1.0 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T DUF2619 PF10942.3 CCF32770.1 - 0.25 11.3 2.2 0.29 11.1 0.8 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2619) Pkinase PF00069.20 CCF32771.1 - 2e-64 217.2 0.0 2.4e-64 217.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF32771.1 - 3.5e-31 108.2 0.0 4.5e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF32771.1 - 0.012 14.6 0.0 0.045 12.7 0.0 1.9 2 1 0 2 2 2 0 Kinase-like Attacin_C PF03769.10 CCF32771.1 - 0.12 12.5 0.6 0.24 11.5 0.4 1.4 1 0 0 1 1 1 0 Attacin, C-terminal region Asparaginase PF00710.15 CCF32772.1 - 6.2e-101 337.3 0.0 8.6e-101 336.9 0.0 1.2 1 0 0 1 1 1 1 Asparaginase Ank_2 PF12796.2 CCF32772.1 - 7.5e-14 51.8 0.1 1.5e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF32772.1 - 1e-12 48.2 0.1 4.8e-07 30.1 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 CCF32772.1 - 2.8e-11 42.6 0.0 0.00022 20.8 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.1 CCF32772.1 - 3.2e-10 39.9 0.1 7.3e-07 29.2 0.2 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF32772.1 - 2.8e-06 27.0 0.0 0.17 12.2 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat GRIM-19 PF06212.7 CCF32773.1 - 5.4e-24 84.3 0.1 1e-23 83.4 0.0 1.4 1 1 0 1 1 1 1 GRIM-19 protein Bac_rhamnosid PF05592.6 CCF32774.1 - 1.7e-29 102.4 0.0 2.3e-12 45.9 0.0 3.1 3 0 0 3 3 3 3 Bacterial alpha-L-rhamnosidase DUF1080 PF06439.6 CCF32774.1 - 0.0075 16.1 0.0 0.12 12.2 0.0 2.5 2 1 0 2 2 2 1 Domain of Unknown Function (DUF1080) DUF608 PF04685.8 CCF32774.1 - 0.069 11.8 0.3 0.11 11.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF608 Cnd1 PF12717.2 CCF32775.1 - 3.4e-57 193.1 3.3 4.1e-52 176.6 0.9 2.8 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 CCF32775.1 - 8e-11 42.0 3.6 8e-05 22.8 0.1 5.2 4 2 0 4 4 4 2 HEAT repeats HEAT PF02985.17 CCF32775.1 - 5.2e-08 32.3 10.3 0.02 14.9 0.0 6.4 7 0 0 7 7 7 2 HEAT repeat HEAT_EZ PF13513.1 CCF32775.1 - 4e-06 27.1 5.4 0.012 16.1 0.1 5.1 4 0 0 4 4 4 2 HEAT-like repeat Adaptin_N PF01602.15 CCF32775.1 - 5.9e-06 24.8 2.9 0.002 16.5 0.3 3.2 3 0 0 3 3 3 2 Adaptin N terminal region DUF2435 PF10363.4 CCF32775.1 - 0.0029 17.4 0.0 1.2 9.0 0.0 3.6 2 1 1 3 3 3 1 Protein of unknown function (DUF2435) Cnd3 PF12719.2 CCF32775.1 - 0.015 14.2 4.0 0.055 12.4 2.0 2.6 2 1 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain Ssl1 PF04056.9 CCF32775.1 - 0.036 13.6 0.0 0.37 10.3 0.0 2.5 2 0 0 2 2 2 0 Ssl1-like Corona_nucleoca PF00937.13 CCF32775.1 - 6 5.7 8.3 0.31 9.9 1.8 1.6 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein CPSF_A PF03178.10 CCF32776.1 - 2e-76 257.1 0.0 3.1e-76 256.5 0.0 1.3 1 0 0 1 1 1 1 CPSF A subunit region Pal1 PF08316.6 CCF32777.1 - 9.1e-09 35.9 0.3 2.1e-08 34.7 0.0 1.7 2 0 0 2 2 2 1 Pal1 cell morphology protein HVSL PF09749.4 CCF32778.1 - 8e-60 201.8 0.0 9.6e-60 201.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein DUF3760 PF12586.3 CCF32778.1 - 0.065 13.0 0.1 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3760) MFS_1 PF07690.11 CCF32779.1 - 1e-14 54.0 18.5 1.4e-14 53.6 12.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TauD PF02668.11 CCF32780.1 - 7.5e-43 147.0 0.0 9.3e-43 146.7 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Ax_dynein_light PF10211.4 CCF32780.1 - 0.035 13.9 0.0 0.073 12.9 0.0 1.4 1 0 0 1 1 1 0 Axonemal dynein light chain MFS_1 PF07690.11 CCF32782.1 - 3.3e-30 104.9 30.9 1.4e-29 102.9 19.9 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily HET PF06985.6 CCF32783.1 - 1.3e-23 83.6 0.0 2.5e-23 82.7 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DLH PF01738.13 CCF32783.1 - 0.083 12.1 0.0 0.25 10.5 0.0 1.7 1 1 1 2 2 2 0 Dienelactone hydrolase family PP2C PF00481.16 CCF32784.1 - 4.1e-42 144.3 0.0 6.6e-42 143.6 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 CCF32784.1 - 0.0089 15.7 0.1 0.5 10.0 0.0 2.7 3 0 0 3 3 3 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 CCF32784.1 - 0.02 14.3 0.1 0.041 13.2 0.0 1.5 1 1 0 1 1 1 0 Protein phosphatase 2C Pkinase PF00069.20 CCF32785.1 - 1.2e-70 237.6 0.0 2.2e-70 236.8 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF32785.1 - 2.6e-30 105.3 0.0 4.9e-29 101.1 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF32785.1 - 8e-06 25.0 0.0 0.37 9.6 0.0 3.1 3 0 0 3 3 3 2 Kinase-like Kdo PF06293.9 CCF32785.1 - 0.026 13.6 0.0 0.041 12.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SMC_N PF02463.14 CCF32787.1 - 1.8e-74 249.7 19.3 9.8e-74 247.2 13.4 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 CCF32787.1 - 1.2e-26 92.9 0.0 5.3e-26 90.9 0.0 2.2 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 CCF32787.1 - 1.9e-10 41.2 14.3 1.5e-05 25.1 0.0 3.8 3 2 0 3 3 3 2 AAA domain AAA_29 PF13555.1 CCF32787.1 - 0.00015 21.2 0.0 0.00031 20.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Tropomyosin_1 PF12718.2 CCF32787.1 - 0.003 17.4 20.1 0.003 17.4 13.9 8.0 3 2 6 9 9 7 1 Tropomyosin like IncA PF04156.9 CCF32787.1 - 0.0058 16.2 21.6 0.0058 16.2 15.0 8.0 3 2 6 9 9 8 2 IncA protein Spc7 PF08317.6 CCF32787.1 - 0.25 9.9 110.6 0.0076 14.9 17.0 6.2 2 2 4 6 6 6 0 Spc7 kinetochore protein Reo_sigmaC PF04582.7 CCF32787.1 - 0.63 9.1 30.2 0.028 13.6 1.2 4.7 4 2 1 5 5 5 0 Reovirus sigma C capsid protein Plasmid_stabil PF05016.9 CCF32787.1 - 0.88 10.0 6.5 1.8 9.0 0.4 3.6 2 0 0 2 2 2 0 Plasmid stabilisation system protein ABC_tran PF00005.22 CCF32787.1 - 0.93 9.7 0.0 0.93 9.7 0.0 7.1 5 3 0 5 5 4 0 ABC transporter AAA_13 PF13166.1 CCF32787.1 - 7 4.9 110.4 0.029 12.8 8.9 5.8 4 2 1 6 6 6 0 AAA domain ELYS PF13934.1 CCF32788.1 - 2.2e-36 125.7 0.1 2.7e-36 125.3 0.1 1.1 1 0 0 1 1 1 1 Nuclear pore complex assembly PAN_4 PF14295.1 CCF32789.1 - 0.0032 17.1 3.4 0.0065 16.1 2.4 1.6 1 1 0 1 1 1 1 PAN domain Glyco_transf_22 PF03901.12 CCF32790.1 - 5.6e-60 203.5 22.9 7e-60 203.1 15.9 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family PMT_2 PF13231.1 CCF32790.1 - 0.0053 16.6 7.8 0.0053 16.6 5.4 2.3 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Skp1 PF01466.14 CCF32791.1 - 1.2e-39 134.2 1.1 2.6e-39 133.0 0.8 1.6 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.10 CCF32791.1 - 3.2e-20 71.9 0.2 7e-20 70.8 0.1 1.6 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain DUF4375 PF14300.1 CCF32791.1 - 0.0092 15.9 0.5 0.0092 15.9 0.4 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4375) SecE PF00584.15 CCF32793.1 - 3.4e-12 45.7 0.0 3.8e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex WD40 PF00400.27 CCF32794.1 - 1.3e-26 91.4 12.1 1.1e-08 34.6 0.3 6.7 7 0 0 7 7 7 6 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 CCF32794.1 - 0.00093 17.5 3.4 0.17 10.1 0.0 3.8 3 1 1 4 4 4 2 Cytochrome D1 heme domain PD40 PF07676.7 CCF32794.1 - 0.036 13.7 0.2 0.18 11.5 0.0 2.3 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat BSP_II PF05432.6 CCF32794.1 - 0.15 11.2 9.7 0.3 10.3 6.7 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Daxx PF03344.10 CCF32794.1 - 3 6.2 8.7 4.9 5.5 6.0 1.3 1 0 0 1 1 1 0 Daxx Family UPF0016 PF01169.14 CCF32795.1 - 2.5e-42 142.8 24.8 1.6e-22 79.4 5.1 2.2 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 HET PF06985.6 CCF32796.1 - 6e-22 78.3 0.0 1.3e-21 77.2 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Peptidase_C2 PF00648.16 CCF32797.1 - 2.1e-50 171.3 0.8 9.7e-35 119.9 0.4 2.6 2 0 0 2 2 2 2 Calpain family cysteine protease COesterase PF00135.23 CCF32799.1 - 4.2e-78 263.3 0.0 1.3e-77 261.7 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF32799.1 - 1.1e-09 38.1 0.3 6.1e-07 29.2 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF32799.1 - 0.00016 20.9 0.1 0.00029 20.1 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family EKR PF10371.4 CCF32799.1 - 0.07 12.7 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function NmrA PF05368.8 CCF32800.1 - 2.5e-17 62.9 0.0 4.1e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF32800.1 - 1.7e-12 47.7 0.0 2.4e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 CCF32800.1 - 5.9e-07 28.8 0.1 9.1e-07 28.1 0.1 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 CCF32800.1 - 0.00091 19.3 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.10 CCF32800.1 - 0.0038 17.1 0.0 0.0065 16.3 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Epimerase PF01370.16 CCF32800.1 - 0.033 13.6 0.0 0.065 12.6 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.12 CCF32800.1 - 0.1 13.0 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Fungal_trans PF04082.13 CCF32801.1 - 6e-11 41.7 0.0 9.3e-11 41.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Git3 PF11710.3 CCF32802.1 - 3.2e-23 82.3 6.2 4.6e-23 81.8 4.3 1.2 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.16 CCF32802.1 - 1.3e-15 57.2 0.0 1.9e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dicty_CAR PF05462.6 CCF32802.1 - 1.2e-08 34.2 7.7 1.5e-06 27.3 4.6 2.1 2 0 0 2 2 2 2 Slime mold cyclic AMP receptor Git3_C PF11970.3 CCF32802.1 - 0.00012 21.7 0.5 0.0016 18.1 0.0 2.5 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term Cu_amine_oxid PF01179.15 CCF32803.1 - 2.8e-56 191.0 1.7 3.5e-56 190.7 1.2 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain DUF1965 PF09248.5 CCF32803.1 - 4.1e-10 39.4 0.0 1.2e-09 37.8 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) ADH_zinc_N PF00107.21 CCF32804.1 - 2.7e-13 49.6 0.0 4.4e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF32804.1 - 8.8e-12 46.0 0.1 2.5e-11 44.5 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF32804.1 - 3.8e-08 33.0 0.1 1.1e-07 31.5 0.1 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain NmrA PF05368.8 CCF32805.1 - 1.2e-31 109.7 0.0 1.4e-31 109.5 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF32805.1 - 6.3e-11 42.6 0.1 9e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding DapB_N PF01113.15 CCF32805.1 - 0.00013 21.8 0.3 0.00022 21.1 0.2 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Saccharop_dh PF03435.13 CCF32805.1 - 0.00028 19.9 0.2 0.00041 19.4 0.2 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Epimerase PF01370.16 CCF32805.1 - 0.00039 19.9 0.0 0.012 15.0 0.1 2.5 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.19 CCF32805.1 - 0.0013 19.0 0.0 0.0022 18.3 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.14 CCF32805.1 - 0.007 15.1 0.1 0.013 14.2 0.1 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family 5_nucleotid_C PF02872.13 CCF32806.1 - 3.1e-39 134.4 0.0 5.6e-39 133.6 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.23 CCF32806.1 - 3.3e-07 29.9 1.2 3.6e-07 29.7 0.1 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CCF32806.1 - 0.0016 18.3 0.0 0.0032 17.3 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Mucin PF01456.12 CCF32809.1 - 0.076 12.7 10.9 0.13 12.0 7.5 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Tannase PF07519.6 CCF32811.1 - 5.1e-92 309.0 0.1 6.3e-92 308.7 0.1 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_6 PF12697.2 CCF32811.1 - 4.2e-05 23.5 2.1 0.00052 19.9 1.4 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF32811.1 - 0.00026 20.2 0.0 0.12 11.5 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family AAA PF00004.24 CCF32812.1 - 2.6e-06 27.6 0.0 4.2e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) UPF0079 PF02367.12 CCF32812.1 - 7.8e-05 22.3 0.0 0.00015 21.4 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 AAA_17 PF13207.1 CCF32812.1 - 0.00011 22.9 0.0 0.00032 21.4 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.1 CCF32812.1 - 0.00028 20.9 0.2 0.00051 20.0 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.22 CCF32812.1 - 0.00041 20.6 0.0 0.00078 19.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter T2SE PF00437.15 CCF32812.1 - 0.00074 18.4 0.0 0.0012 17.8 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.1 CCF32812.1 - 0.0011 18.6 0.1 0.0027 17.4 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_18 PF13238.1 CCF32812.1 - 0.0016 18.7 0.0 0.0035 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CCF32812.1 - 0.0021 17.9 0.0 0.0039 17.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 CCF32812.1 - 0.0033 17.4 0.0 0.0052 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CCF32812.1 - 0.0058 16.7 0.2 0.026 14.6 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.1 CCF32812.1 - 0.007 15.9 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 CCF32812.1 - 0.012 15.2 0.0 0.029 14.0 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Viral_helicase1 PF01443.13 CCF32812.1 - 0.013 14.9 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.12 CCF32812.1 - 0.014 14.8 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein PduV-EutP PF10662.4 CCF32812.1 - 0.015 14.7 0.0 0.026 14.0 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.1 CCF32812.1 - 0.015 14.6 0.6 0.035 13.5 0.3 1.6 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 CCF32812.1 - 0.019 14.4 0.0 0.044 13.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.17 CCF32812.1 - 0.022 13.6 0.0 0.034 13.0 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.17 CCF32812.1 - 0.026 14.7 0.0 0.052 13.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.1 CCF32812.1 - 0.032 14.1 0.0 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 CCF32812.1 - 0.037 13.1 0.0 0.06 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 MobB PF03205.9 CCF32812.1 - 0.062 12.9 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_5 PF07728.9 CCF32812.1 - 0.064 12.9 0.1 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_10 PF12846.2 CCF32812.1 - 0.066 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain PhoH PF02562.11 CCF32812.1 - 0.087 12.0 0.1 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein DUF815 PF05673.8 CCF32812.1 - 0.14 11.0 0.0 0.21 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_23 PF13476.1 CCF32812.1 - 0.16 12.3 0.0 0.25 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF221 PF02714.10 CCF32813.1 - 1.3e-81 273.9 18.8 1.3e-81 273.9 13.0 1.4 2 0 0 2 2 2 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 CCF32813.1 - 3.2e-39 133.9 3.6 3.2e-39 133.9 2.5 2.8 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport DUF4463 PF14703.1 CCF32813.1 - 5e-20 71.8 0.4 8.6e-20 71.0 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) 2-Hacid_dh_C PF02826.14 CCF32814.1 - 3.5e-55 185.9 0.0 5.3e-55 185.3 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 CCF32814.1 - 6.9e-33 112.9 0.0 8.8e-33 112.5 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 CCF32814.1 - 6.9e-08 32.4 0.0 2.6e-07 30.6 0.0 1.9 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase CoA_binding_2 PF13380.1 CCF32814.1 - 0.0014 18.7 0.0 0.004 17.3 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain AlaDh_PNT_C PF01262.16 CCF32814.1 - 0.0037 16.8 6.1 0.38 10.3 0.1 2.8 2 1 1 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain Oxidored_nitro PF00148.14 CCF32814.1 - 0.005 15.5 0.0 0.0059 15.3 0.0 1.1 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase IlvN PF07991.7 CCF32814.1 - 0.0068 15.7 0.0 0.056 12.8 0.0 2.1 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, catalytic domain Semialdhyde_dh PF01118.19 CCF32814.1 - 0.0094 16.2 0.5 3.1 8.1 0.1 2.5 2 0 0 2 2 2 2 Semialdehyde dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.16 CCF32814.1 - 0.011 15.5 0.0 0.027 14.3 0.0 1.6 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain GFO_IDH_MocA PF01408.17 CCF32814.1 - 0.046 14.2 3.4 0.64 10.5 0.0 2.9 2 1 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Methyltransf_18 PF12847.2 CCF32814.1 - 0.046 14.2 0.2 23 5.6 0.0 2.9 2 1 0 2 2 2 0 Methyltransferase domain HisG_C PF08029.6 CCF32814.1 - 0.076 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 HisG, C-terminal domain MFS_1 PF07690.11 CCF32815.1 - 3.7e-41 141.0 28.1 3.7e-41 141.0 19.5 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF32815.1 - 1.9e-08 33.3 22.4 9.1e-08 31.0 15.5 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 CCF32815.1 - 2.7e-08 32.4 3.2 3.9e-08 31.9 2.2 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) FPN1 PF06963.7 CCF32815.1 - 0.0019 16.6 0.1 0.0044 15.4 0.1 1.5 1 0 0 1 1 1 1 Ferroportin1 (FPN1) Asp PF00026.18 CCF32816.1 - 9.2e-71 238.6 5.5 1.1e-70 238.4 3.8 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CCF32816.1 - 4.8e-08 33.1 0.5 3.3e-07 30.4 0.2 2.3 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 CCF32816.1 - 0.00015 22.1 1.8 0.0073 16.7 0.2 3.2 2 2 1 3 3 3 1 Aspartyl protease TAXi_C PF14541.1 CCF32816.1 - 0.089 12.3 0.5 1 8.8 0.1 2.8 2 2 0 2 2 2 0 Xylanase inhibitor C-terminal Methyltransf_31 PF13847.1 CCF32817.1 - 9.4e-12 44.7 0.0 1.3e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF32817.1 - 1.7e-08 34.8 0.0 4.1e-08 33.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF32817.1 - 2.2e-07 31.4 0.0 4e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 CCF32817.1 - 8.6e-07 28.7 0.0 1.6e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.7 CCF32817.1 - 1e-05 25.8 0.0 1.9e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF32817.1 - 1.8e-05 24.5 0.0 2.7e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF32817.1 - 0.0001 22.2 0.1 0.00021 21.2 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF32817.1 - 0.00032 20.9 0.0 0.00051 20.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF32817.1 - 0.0013 18.1 0.1 0.0022 17.3 0.1 1.4 1 1 0 1 1 1 1 Methyltransferase small domain UPF0020 PF01170.13 CCF32817.1 - 0.0026 17.3 0.1 0.0057 16.2 0.0 1.5 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Ubie_methyltran PF01209.13 CCF32817.1 - 0.0042 16.2 0.0 0.0059 15.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.8 CCF32817.1 - 0.011 14.9 0.2 0.015 14.4 0.2 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DDE_Tnp_IS66_C PF13817.1 CCF32817.1 - 0.015 15.2 0.0 0.035 14.1 0.0 1.6 1 0 0 1 1 1 0 IS66 C-terminal element Amidase PF01425.16 CCF32818.1 - 4.2e-89 299.4 0.0 5.2e-89 299.1 0.0 1.1 1 0 0 1 1 1 1 Amidase DAHP_synth_2 PF01474.11 CCF32819.1 - 2.1e-192 639.3 0.0 2.4e-192 639.1 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family DUF440 PF04269.7 CCF32820.1 - 0.12 12.4 1.0 0.38 10.8 0.7 1.9 1 0 0 1 1 1 0 Protein of unknown function, DUF440 Aa_trans PF01490.13 CCF32821.1 - 3.7e-36 124.4 33.8 4.3e-36 124.2 23.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Abhydrolase_6 PF12697.2 CCF32822.1 - 9.8e-22 77.9 0.0 1.1e-21 77.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF32822.1 - 1.1e-16 61.1 0.0 1.7e-10 40.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF32822.1 - 3.3e-08 33.3 0.0 9.3e-08 31.9 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.9 CCF32822.1 - 0.00077 18.0 0.0 0.002 16.6 0.0 1.6 2 0 0 2 2 2 1 Ndr family PhoPQ_related PF10142.4 CCF32822.1 - 0.064 11.7 0.0 4.5 5.6 0.0 2.1 2 0 0 2 2 2 0 PhoPQ-activated pathogenicity-related protein Peptidase_M16_C PF05193.16 CCF32823.1 - 1.3e-54 184.6 0.0 5.3e-54 182.6 0.0 1.9 1 1 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 CCF32823.1 - 1e-39 135.6 0.0 3e-39 134.1 0.0 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) S1 PF00575.18 CCF32825.1 - 2.1e-07 30.8 10.7 0.13 12.3 0.1 5.5 5 2 0 5 5 5 3 S1 RNA binding domain EXOSC1 PF10447.4 CCF32825.1 - 0.057 13.3 0.2 0.45 10.5 0.0 2.6 2 0 0 2 2 2 0 Exosome component EXOSC1/CSL4 DNA_pol_phi PF04931.8 CCF32825.1 - 0.063 11.0 1.3 0.09 10.5 0.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi alpha-hel2 PF14456.1 CCF32825.1 - 0.14 10.8 0.2 0.43 9.3 0.0 1.7 1 1 1 2 2 2 0 Alpha-helical domain 2 4HBT_3 PF13622.1 CCF32826.1 - 4.2e-45 154.4 0.5 5.5e-45 154.1 0.3 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.10 CCF32826.1 - 2.7e-25 88.5 0.0 2.4e-10 40.1 0.0 4.1 3 1 0 3 3 3 3 Acyl-CoA thioesterase Oxysterol_BP PF01237.13 CCF32827.1 - 6.2e-131 436.0 0.1 2.4e-130 434.1 0.0 2.0 2 0 0 2 2 2 1 Oxysterol-binding protein Ank PF00023.25 CCF32827.1 - 4.7e-19 67.1 0.1 2.5e-07 30.1 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.2 CCF32827.1 - 5.6e-19 68.2 0.0 1.4e-12 47.7 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF32827.1 - 7.5e-17 61.3 0.0 2.6e-09 37.3 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF32827.1 - 8.5e-17 60.8 0.5 2e-09 37.3 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF32827.1 - 2.8e-16 57.9 0.0 7.1e-05 22.6 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat PH PF00169.24 CCF32827.1 - 4.5e-11 42.8 0.5 9.8e-11 41.7 0.3 1.6 1 0 0 1 1 1 1 PH domain PH_8 PF15409.1 CCF32827.1 - 1.2e-07 31.6 1.0 3.1e-07 30.3 0.7 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Zip PF02535.17 CCF32828.1 - 6.6e-34 117.3 21.2 4.8e-32 111.2 14.7 3.4 1 1 0 1 1 1 1 ZIP Zinc transporter Hat1_N PF10394.4 CCF32829.1 - 1.7e-34 119.2 0.0 5.4e-34 117.5 0.0 1.8 2 0 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_7 PF13508.1 CCF32829.1 - 0.00062 19.8 0.0 0.0013 18.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CCF32829.1 - 0.0023 17.9 0.0 0.0055 16.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 CCF32829.1 - 0.049 13.7 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain EHN PF06441.7 CCF32831.1 - 4.6e-19 68.3 0.5 8.3e-19 67.5 0.4 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_6 PF12697.2 CCF32831.1 - 7.5e-05 22.7 2.8 0.00056 19.8 1.6 2.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family TaqI_C PF12950.2 CCF32831.1 - 0.0043 16.7 0.1 0.0067 16.1 0.0 1.2 1 0 0 1 1 1 1 TaqI-like C-terminal specificity domain TIMELESS PF04821.9 CCF32832.1 - 1.2e-91 306.6 0.0 1.2e-91 306.6 0.0 2.8 4 0 0 4 4 4 1 Timeless protein TIMELESS_C PF05029.8 CCF32832.1 - 6.9e-35 121.0 6.1 6.9e-35 121.0 4.2 3.0 2 1 1 3 3 3 1 Timeless protein C terminal region 3HCDH_N PF02737.13 CCF32833.1 - 9.8e-53 178.4 0.8 1.3e-52 178.0 0.5 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.17 CCF32833.1 - 1.1e-34 118.7 0.0 2.3e-34 117.6 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 CCF32833.1 - 0.00032 20.5 0.1 0.00086 19.1 0.1 1.7 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Saccharop_dh PF03435.13 CCF32833.1 - 0.00043 19.3 0.1 0.00059 18.9 0.1 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase DAO PF01266.19 CCF32833.1 - 0.0021 17.0 0.5 0.0078 15.1 0.3 1.8 1 1 1 2 2 2 1 FAD dependent oxidoreductase TrkA_N PF02254.13 CCF32833.1 - 0.019 14.9 0.0 0.22 11.5 0.0 2.3 2 0 0 2 2 2 0 TrkA-N domain NAD_Gly3P_dh_N PF01210.18 CCF32833.1 - 0.021 14.5 1.9 0.057 13.1 1.3 1.8 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pyr_redox_3 PF13738.1 CCF32833.1 - 0.039 14.0 0.9 0.086 12.8 0.5 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.9 CCF32833.1 - 0.097 12.0 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain F420_oxidored PF03807.12 CCF32833.1 - 0.14 12.5 3.2 0.38 11.2 1.5 2.4 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent SMI1_KNR4 PF09346.5 CCF32834.1 - 2e-24 86.0 0.0 3.2e-24 85.4 0.0 1.3 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) UPF0220 PF05255.6 CCF32835.1 - 9.6e-64 213.6 3.5 1.1e-63 213.4 2.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) SWIM PF04434.12 CCF32837.1 - 2.6e-05 23.5 1.2 4.1e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 SWIM zinc finger Sulfate_transp PF00916.15 CCF32838.1 - 2e-72 243.5 15.2 3.6e-72 242.7 10.5 1.4 1 0 0 1 1 1 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 CCF32838.1 - 1e-31 108.4 2.7 1e-31 108.4 1.9 3.4 4 0 0 4 4 4 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 CCF32838.1 - 3.2e-09 36.2 0.0 6.4e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 STAS domain p450 PF00067.17 CCF32839.1 - 3.8e-32 111.4 0.0 5.6e-32 110.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ketoacyl-synt PF00109.21 CCF32840.1 - 2.9e-78 262.8 0.0 9.1e-78 261.2 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 CCF32840.1 - 4.6e-52 177.3 0.0 8.4e-52 176.4 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.1 CCF32840.1 - 5.6e-41 140.6 0.0 9.6e-41 139.8 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.17 CCF32840.1 - 1.4e-27 95.8 0.1 5.9e-27 93.8 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 CCF32840.1 - 5.9e-06 25.4 0.0 1.2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Arylsulfotran_2 PF14269.1 CCF32841.1 - 3.7e-74 249.5 1.0 4.7e-74 249.2 0.7 1.1 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.6 CCF32841.1 - 9.3e-14 50.7 0.1 7.2e-13 47.8 0.1 1.9 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) DUF3824 PF12868.2 CCF32843.1 - 1.9e-05 25.5 26.1 1.9e-05 25.5 18.1 9.0 5 4 4 10 10 10 2 Domain of unknwon function (DUF3824) DUF4366 PF14283.1 CCF32843.1 - 0.098 12.0 10.5 0.6 9.5 0.0 3.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4366) CopD PF05425.8 CCF32843.1 - 0.7 10.1 4.1 4 7.6 0.2 3.1 3 0 0 3 3 3 0 Copper resistance protein D DUF2910 PF11139.3 CCF32843.1 - 1.5 7.9 3.9 44 3.1 2.6 2.8 2 1 2 4 4 4 0 Protein of unknown function (DUF2910) DUF202 PF02656.10 CCF32843.1 - 1.8 8.8 4.3 22 5.3 0.2 3.6 2 1 2 4 4 4 0 Domain of unknown function (DUF202) DnaJ PF00226.26 CCF32844.1 - 1.6e-26 91.8 1.1 2.5e-26 91.1 0.8 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 CCF32844.1 - 6.5e-14 51.7 18.6 1.2e-13 50.8 12.9 1.5 1 0 0 1 1 1 1 DnaJ central domain CTDII PF01556.13 CCF32844.1 - 1.7e-12 47.0 0.0 1e-11 44.5 0.0 2.2 2 0 0 2 2 2 1 DnaJ C terminal domain HypA PF01155.14 CCF32844.1 - 0.013 15.1 7.8 0.25 11.0 0.5 2.3 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family DUF702 PF05142.7 CCF32844.1 - 0.037 14.2 5.3 0.087 13.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF702) OB_NTP_bind PF07717.11 CCF32845.1 - 5.3e-28 97.1 0.0 1.2e-27 95.9 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 CCF32845.1 - 2.3e-23 82.1 0.1 2.3e-23 82.1 0.1 2.8 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.26 CCF32845.1 - 2.5e-13 49.6 0.0 6.3e-13 48.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 CCF32845.1 - 1.3e-05 25.3 0.1 4.5e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain DEAD PF00270.24 CCF32845.1 - 7e-05 22.3 0.1 0.0002 20.9 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase T2SE PF00437.15 CCF32845.1 - 0.00064 18.7 0.0 0.0016 17.3 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein SRP54 PF00448.17 CCF32845.1 - 0.017 14.5 0.2 0.041 13.3 0.2 1.7 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_14 PF13173.1 CCF32845.1 - 0.024 14.5 1.5 0.23 11.3 0.1 3.0 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.22 CCF32845.1 - 0.28 11.4 0.0 0.28 11.4 0.0 2.8 3 0 0 3 3 3 0 ABC transporter DUF3129 PF11327.3 CCF32848.1 - 1.4e-67 227.0 14.8 3e-67 225.9 10.2 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3129) Cupin_8 PF13621.1 CCF32850.1 - 1.1e-66 224.8 0.1 1.4e-66 224.5 0.1 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 CCF32850.1 - 1.9e-06 27.3 0.0 0.00036 19.8 0.1 2.2 2 0 0 2 2 2 2 Cupin superfamily protein JmjC PF02373.17 CCF32850.1 - 0.06 13.5 0.3 0.69 10.1 0.0 2.6 3 0 0 3 3 3 0 JmjC domain, hydroxylase N-SET PF11764.3 CCF32851.1 - 6.1e-34 117.3 0.1 6.1e-34 117.3 0.1 2.2 3 0 0 3 3 3 1 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.3 CCF32851.1 - 1.3e-21 75.6 1.3 5.4e-21 73.6 0.3 2.3 2 0 0 2 2 2 1 Histone lysine methyltransferase SET associated SET PF00856.23 CCF32851.1 - 1.4e-21 77.5 0.1 1.4e-21 77.5 0.1 3.3 4 2 0 4 4 4 1 SET domain RRM_1 PF00076.17 CCF32851.1 - 0.024 14.2 0.3 0.61 9.7 0.0 2.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DNA_pol3_tau_5 PF12170.3 CCF32852.1 - 0.043 13.7 0.2 0.06 13.2 0.1 1.2 1 0 0 1 1 1 0 DNA polymerase III tau subunit V interacting with alpha P4Ha_N PF08336.6 CCF32853.1 - 0.058 13.2 0.5 0.23 11.3 0.2 2.0 1 1 1 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region MbeD_MobD PF04899.7 CCF32853.1 - 0.27 11.1 0.1 0.27 11.1 0.1 2.4 3 0 0 3 3 3 0 MbeD/MobD like Kelch_6 PF13964.1 CCF32854.1 - 1.4e-38 129.4 11.2 6.9e-09 35.5 0.0 6.2 5 2 2 7 7 7 5 Kelch motif Kelch_4 PF13418.1 CCF32854.1 - 4.2e-37 125.6 8.1 2.1e-08 33.7 0.2 5.5 4 1 1 5 5 5 5 Galactose oxidase, central domain Kelch_1 PF01344.20 CCF32854.1 - 8.6e-36 121.2 5.0 6.5e-08 31.9 0.1 6.6 6 1 0 6 6 6 5 Kelch motif Kelch_3 PF13415.1 CCF32854.1 - 5.5e-31 106.0 15.5 8e-07 29.0 0.0 6.8 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.10 CCF32854.1 - 6.4e-20 70.0 15.0 0.00015 21.4 0.1 6.8 6 3 0 6 6 6 4 Kelch motif Kelch_5 PF13854.1 CCF32854.1 - 1.1e-18 66.7 12.8 3.1e-07 30.1 0.1 6.3 6 0 0 6 6 6 6 Kelch motif PQQ_3 PF13570.1 CCF32854.1 - 0.0051 17.0 9.6 1.5 9.1 0.1 4.4 4 0 0 4 4 4 2 PQQ-like domain MFS_1 PF07690.11 CCF32855.1 - 9.8e-44 149.4 29.5 9.8e-44 149.4 20.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Glyco_hydro_61 PF03443.9 CCF32856.1 - 1e-46 159.4 0.0 1.3e-46 159.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DUF4469 PF14734.1 CCF32856.1 - 0.15 11.8 0.0 0.41 10.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4469) with IG-like fold DUF1769 PF08588.5 CCF32857.1 - 2.5e-28 97.8 1.0 3.8e-28 97.2 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1769) DUF3506 PF12014.3 CCF32858.1 - 7.7e-41 139.0 0.0 1.6e-40 138.0 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3506) Glyco_hydro_43 PF04616.9 CCF32859.1 - 4.1e-62 209.8 8.8 3.5e-55 187.1 1.3 2.5 2 0 0 2 2 2 2 Glycosyl hydrolases family 43 Laminin_G_3 PF13385.1 CCF32859.1 - 6.4e-20 71.9 2.5 6.4e-20 71.9 1.7 3.1 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Glyco_hydro_32N PF00251.15 CCF32859.1 - 4.7e-08 32.7 3.4 0.0019 17.6 0.3 2.8 3 0 0 3 3 3 2 Glycosyl hydrolases family 32 N-terminal domain Xylanase PF13201.1 CCF32859.1 - 6.3e-05 21.9 0.0 0.00024 20.0 0.0 1.9 3 0 0 3 3 3 1 Putative glycoside hydrolase xylanase Sialidase PF02973.11 CCF32859.1 - 0.0065 15.4 0.2 0.012 14.6 0.1 1.4 1 0 0 1 1 1 1 Sialidase, N-terminal domain HSP70 PF00012.15 CCF32860.1 - 2.6e-269 894.2 5.5 3e-269 894.0 3.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 CCF32860.1 - 3.9e-17 61.8 0.1 9e-16 57.3 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 CCF32860.1 - 0.00069 19.2 0.0 0.0014 18.2 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.13 CCF32860.1 - 0.0077 15.3 0.1 0.032 13.3 0.0 2.0 1 1 1 2 2 2 1 Hydantoinase/oxoprolinase FtsA PF14450.1 CCF32860.1 - 0.048 13.4 3.6 2 8.2 0.2 3.1 2 2 0 2 2 2 0 Cell division protein FtsA DUF4404 PF14357.1 CCF32860.1 - 1.8 9.0 7.7 1.8 9.0 1.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF1843 PF08898.5 CCF32860.1 - 7.8 6.6 6.0 1.2 9.2 0.5 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) DUF3128 PF11326.3 CCF32861.1 - 6.3e-28 96.7 3.1 1e-27 96.0 2.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) DLIC PF05783.6 CCF32861.1 - 1.6 7.3 5.4 2.1 6.9 3.8 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) DUF566 PF04484.7 CCF32861.1 - 2.2 7.7 6.7 3.4 7.1 4.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF566) RNA12 PF10443.4 CCF32862.1 - 1e-159 531.6 3.1 4.7e-159 529.5 0.6 2.0 2 0 0 2 2 2 1 RNA12 protein RRM_1 PF00076.17 CCF32862.1 - 3.2e-05 23.4 0.0 0.00015 21.3 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF32862.1 - 0.00039 20.2 0.0 0.00096 18.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Arch_ATPase PF01637.13 CCF32862.1 - 0.0009 19.0 0.8 0.014 15.0 0.5 2.6 1 1 0 1 1 1 1 Archaeal ATPase RRM_6 PF14259.1 CCF32862.1 - 0.019 14.9 0.0 0.19 11.7 0.0 2.6 3 0 0 3 3 3 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF2487 PF10673.4 CCF32862.1 - 0.036 13.8 0.0 0.079 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2487) Strep_SA_rep PF06696.6 CCF32862.1 - 0.061 13.1 0.5 0.17 11.6 0.3 1.8 1 0 0 1 1 1 0 Streptococcal surface antigen repeat peroxidase PF00141.18 CCF32863.1 - 1e-20 74.2 0.5 1.8e-20 73.4 0.3 1.3 1 0 0 1 1 1 1 Peroxidase PSI_PSAK PF01241.13 CCF32863.1 - 0.075 13.0 0.1 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Photosystem I psaG / psaK NAD_binding_10 PF13460.1 CCF32864.1 - 1e-23 84.2 0.1 1.4e-23 83.8 0.1 1.1 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF32864.1 - 5.4e-05 22.7 0.0 9.1e-05 21.9 0.0 1.3 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 CCF32864.1 - 0.016 14.4 0.0 1.2 8.3 0.0 2.1 2 0 0 2 2 2 0 NmrA-like family Methyltransf_23 PF13489.1 CCF32865.1 - 1.9e-21 76.4 0.0 2.8e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF32865.1 - 1.5e-09 38.4 0.1 1.5e-08 35.1 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF32865.1 - 2.1e-09 37.1 0.0 6.9e-09 35.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF32865.1 - 5.4e-06 26.8 0.0 9.8e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF32865.1 - 3.1e-05 24.3 0.0 0.00012 22.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF32865.1 - 5.9e-05 23.3 0.0 0.00012 22.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF32865.1 - 0.0063 15.9 0.0 0.09 12.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain CopK PF11525.3 CCF32865.1 - 0.01 15.4 0.1 0.022 14.4 0.1 1.5 1 0 0 1 1 1 0 Copper resistance protein K Mito_carr PF00153.22 CCF32866.1 - 2.6e-67 222.5 3.3 4.8e-24 83.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein CENP-X PF09415.5 CCF32867.1 - 3.7e-24 84.3 1.0 8e-24 83.2 0.0 1.9 2 0 0 2 2 2 1 CENP-S associating Centromere protein X AT_hook PF02178.14 CCF32867.1 - 0.024 14.2 0.2 0.089 12.5 0.1 2.0 1 0 0 1 1 1 0 AT hook motif DUF4228 PF14009.1 CCF32867.1 - 0.19 11.8 1.5 0.21 11.6 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) TRAP_alpha PF03896.11 CCF32867.1 - 0.77 8.6 4.2 1 8.3 2.9 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Nucleoplasmin PF03066.10 CCF32867.1 - 1.7 8.1 6.6 2.4 7.6 4.6 1.2 1 0 0 1 1 1 0 Nucleoplasmin Daxx PF03344.10 CCF32867.1 - 3.2 6.1 8.7 3.9 5.8 6.0 1.0 1 0 0 1 1 1 0 Daxx Family DUF2881 PF11087.3 CCF32869.1 - 0.07 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2881) CCER1 PF15482.1 CCF32869.1 - 9.6 5.7 7.1 10 5.6 4.9 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 AAA PF00004.24 CCF32871.1 - 1.3e-42 145.1 0.0 2.2e-42 144.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF32871.1 - 6.1e-08 32.8 0.1 4.3e-06 26.8 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.9 CCF32871.1 - 1.9e-06 27.6 0.1 3.7e-05 23.4 0.0 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 CCF32871.1 - 2.2e-06 27.6 0.0 7.6e-06 25.9 0.0 1.9 3 0 0 3 3 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 CCF32871.1 - 2.9e-06 27.4 0.0 0.001 19.2 0.0 2.5 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.7 CCF32871.1 - 7.3e-06 25.1 0.0 1.4e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus DUF815 PF05673.8 CCF32871.1 - 0.00023 20.1 0.0 0.00058 18.8 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_19 PF13245.1 CCF32871.1 - 0.00034 20.3 0.0 0.00075 19.1 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_17 PF13207.1 CCF32871.1 - 0.00052 20.8 0.5 0.002 18.9 0.1 2.3 2 1 0 2 2 2 1 AAA domain DUF4200 PF13863.1 CCF32871.1 - 0.00067 19.6 1.5 0.0017 18.3 1.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) AAA_14 PF13173.1 CCF32871.1 - 0.0011 18.8 0.0 0.0027 17.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.8 CCF32871.1 - 0.0017 17.1 0.0 0.0031 16.3 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_33 PF13671.1 CCF32871.1 - 0.0019 18.1 0.0 0.0062 16.4 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.1 CCF32871.1 - 0.0022 18.2 0.2 0.0082 16.4 0.0 2.1 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 CCF32871.1 - 0.0022 17.4 0.0 0.0054 16.1 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.16 CCF32871.1 - 0.003 16.7 0.0 0.0062 15.7 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_11 PF13086.1 CCF32871.1 - 0.0042 16.6 0.3 0.25 10.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 CCF32871.1 - 0.005 16.9 0.0 0.0096 16.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase Zeta_toxin PF06414.7 CCF32871.1 - 0.0054 15.8 0.0 0.012 14.7 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin Sigma54_activat PF00158.21 CCF32871.1 - 0.0075 15.7 0.0 0.025 14.0 0.0 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_25 PF13481.1 CCF32871.1 - 0.009 15.4 0.1 0.047 13.0 0.1 2.1 1 1 1 2 2 2 1 AAA domain AAA_3 PF07726.6 CCF32871.1 - 0.0091 15.5 0.0 0.021 14.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) eIF-1a PF01176.14 CCF32871.1 - 0.014 14.7 0.1 0.027 13.8 0.1 1.4 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 AAA_24 PF13479.1 CCF32871.1 - 0.02 14.5 0.1 0.04 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 CCF32871.1 - 0.023 14.6 0.0 0.047 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 CCF32871.1 - 0.024 14.6 0.0 0.064 13.3 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Arch_ATPase PF01637.13 CCF32871.1 - 0.026 14.2 0.0 0.13 11.9 0.0 2.2 1 1 0 1 1 1 0 Archaeal ATPase ResIII PF04851.10 CCF32871.1 - 0.029 14.2 0.0 0.062 13.1 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit PhoH PF02562.11 CCF32871.1 - 0.031 13.5 0.0 0.056 12.6 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein KaiC PF06745.8 CCF32871.1 - 0.031 13.4 0.4 0.11 11.5 0.0 2.1 3 0 0 3 3 3 0 KaiC NACHT PF05729.7 CCF32871.1 - 0.04 13.5 0.0 0.12 12.0 0.0 1.8 2 0 0 2 2 2 0 NACHT domain UPF0079 PF02367.12 CCF32871.1 - 0.045 13.3 0.0 0.099 12.2 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_30 PF13604.1 CCF32871.1 - 0.077 12.5 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.12 CCF32871.1 - 0.11 11.3 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_23 PF13476.1 CCF32871.1 - 0.11 12.7 3.9 2.6 8.3 0.0 2.6 2 1 0 2 2 2 0 AAA domain MmgE_PrpD PF03972.9 CCF32873.1 - 6e-151 502.6 0.0 7.3e-151 502.3 0.0 1.1 1 0 0 1 1 1 1 MmgE/PrpD family SH3_1 PF00018.23 CCF32874.1 - 1.2e-12 47.0 0.0 1.8e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 CCF32874.1 - 2.9e-08 33.1 0.0 4.4e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 CCF32874.1 - 4.5e-06 26.0 0.0 7.1e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain CARD PF00619.16 CCF32874.1 - 0.098 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Caspase recruitment domain Pex14_N PF04695.8 CCF32874.1 - 1.3 9.0 8.5 7.7 6.5 1.5 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2360 PF10152.4 CCF32874.1 - 6 7.1 16.2 0.58 10.4 1.7 2.4 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) VHS PF00790.14 CCF32875.1 - 1.9e-36 124.7 0.0 4.3e-36 123.6 0.0 1.5 1 0 0 1 1 1 1 VHS domain SH3_9 PF14604.1 CCF32875.1 - 8e-17 60.5 0.2 8e-17 60.5 0.2 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.23 CCF32875.1 - 1e-16 60.0 0.1 2.5e-16 58.7 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 CCF32875.1 - 2.8e-14 52.3 0.1 5.8e-14 51.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.9 CCF32875.1 - 0.0075 16.2 0.3 0.025 14.5 0.2 1.8 1 0 0 1 1 1 1 GAT domain UIM PF02809.15 CCF32875.1 - 0.07 12.7 4.3 0.19 11.3 3.0 1.8 1 0 0 1 1 1 0 Ubiquitin interaction motif TIR PF01582.15 CCF32875.1 - 0.15 11.5 0.3 0.4 10.1 0.2 1.7 2 0 0 2 2 2 0 TIR domain SNF2_N PF00176.18 CCF32876.1 - 4e-79 265.5 0.0 7.2e-79 264.6 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CCF32876.1 - 8.2e-13 48.0 0.0 2.5e-12 46.4 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 CCF32876.1 - 5.7e-07 29.1 0.1 1.5e-06 27.8 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase DEAD_2 PF06733.10 CCF32876.1 - 0.032 13.6 0.0 0.094 12.1 0.0 1.8 1 0 0 1 1 1 0 DEAD_2 Ran-binding PF05508.6 CCF32877.1 - 1.2e-100 336.3 0.0 1.5e-100 336.0 0.0 1.1 1 0 0 1 1 1 1 RanGTP-binding protein GTP_EFTU PF00009.22 CCF32878.1 - 9.1e-46 155.6 0.0 1.7e-45 154.7 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 CCF32878.1 - 1.8e-21 76.1 0.1 5.6e-21 74.5 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 CCF32878.1 - 1.2e-08 34.9 2.1 3.2e-08 33.5 0.2 2.5 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 CCF32878.1 - 0.0015 18.4 0.0 0.0042 17.0 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.15 CCF32878.1 - 0.065 11.9 1.1 0.11 11.1 0.8 1.4 1 0 0 1 1 1 0 G-protein alpha subunit Fungal_trans PF04082.13 CCF32880.1 - 2.5e-15 56.0 1.7 6.1e-15 54.8 0.6 2.3 2 1 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2_jaz PF12171.3 CCF32881.1 - 5.2e-06 26.4 3.7 8.8e-06 25.7 2.6 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CCF32881.1 - 0.00056 20.0 0.9 0.00098 19.2 0.7 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 CCF32881.1 - 0.0066 16.7 0.1 0.015 15.5 0.1 1.6 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_2 PF12756.2 CCF32881.1 - 0.031 14.3 0.2 0.048 13.7 0.2 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.21 CCF32881.1 - 0.031 14.6 1.1 0.055 13.8 0.8 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF965 PF06135.7 CCF32881.1 - 0.051 13.6 0.0 0.094 12.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF965) DUF1691 PF07950.6 CCF32882.1 - 4.7e-42 142.3 6.8 3.2e-25 88.2 1.7 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) DUF4405 PF14358.1 CCF32882.1 - 0.48 10.5 4.4 1.7 8.8 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) DUF4131 PF13567.1 CCF32882.1 - 1.9 7.8 6.0 0.92 8.8 2.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) CFEM PF05730.6 CCF32883.1 - 6.8e-10 38.6 15.2 8.2e-10 38.3 10.5 1.1 1 0 0 1 1 1 1 CFEM domain Gamma-thionin PF00304.15 CCF32883.1 - 1 9.4 7.7 0.18 11.8 2.2 1.9 2 0 0 2 2 2 0 Gamma-thionin family DUF1191 PF06697.7 CCF32884.1 - 0.00094 18.0 0.0 0.0013 17.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1191) PAN_1 PF00024.21 CCF32884.1 - 0.012 15.3 0.2 0.024 14.3 0.1 1.5 1 0 0 1 1 1 0 PAN domain PAN_4 PF14295.1 CCF32884.1 - 0.023 14.4 1.5 0.049 13.3 1.0 1.5 1 0 0 1 1 1 0 PAN domain DnaJ PF00226.26 CCF32885.1 - 1.4e-19 69.5 1.2 1.4e-19 69.5 0.8 2.6 2 1 0 2 2 2 1 DnaJ domain RRM_1 PF00076.17 CCF32886.1 - 3e-10 39.5 0.0 5.2e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF32886.1 - 8.9e-10 38.2 0.0 1.5e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF32886.1 - 9.3e-07 28.7 0.0 1.6e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 CCF32886.1 - 0.00091 19.0 0.0 0.0019 18.0 0.0 1.5 1 0 0 1 1 1 1 RNA binding motif Nup35_RRM_2 PF14605.1 CCF32886.1 - 0.0053 16.5 0.0 0.0096 15.6 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Sterol_MT_C PF08498.5 CCF32887.1 - 8.9e-29 99.2 0.2 1.4e-28 98.6 0.1 1.3 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.7 CCF32887.1 - 3.4e-22 78.7 0.0 6.9e-22 77.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF32887.1 - 2.7e-18 66.0 0.0 4.3e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF32887.1 - 2e-14 53.6 0.0 3.7e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF32887.1 - 1.4e-13 51.0 0.0 2.9e-13 50.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 CCF32887.1 - 1.3e-11 44.0 0.1 2e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.2 CCF32887.1 - 1.9e-11 44.5 0.0 4.9e-11 43.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF32887.1 - 2e-11 44.2 0.1 5.8e-11 42.7 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF32887.1 - 7.6e-11 41.5 0.0 1.4e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 CCF32887.1 - 2.1e-09 37.4 0.0 6e-09 35.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.5 CCF32887.1 - 2.7e-05 23.8 0.1 4.2e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MTS PF05175.9 CCF32887.1 - 9e-05 21.9 0.0 0.00017 21.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain RrnaAD PF00398.15 CCF32887.1 - 0.00085 18.4 0.0 0.0013 17.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PCMT PF01135.14 CCF32887.1 - 0.00085 18.9 0.0 0.0014 18.2 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.7 CCF32887.1 - 0.0013 18.1 0.0 0.0022 17.3 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_29 PF03141.11 CCF32887.1 - 0.0037 15.6 0.0 0.0053 15.1 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PrmA PF06325.8 CCF32887.1 - 0.004 16.3 0.0 0.0082 15.3 0.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.13 CCF32887.1 - 0.015 14.4 0.2 0.033 13.3 0.0 1.6 2 0 0 2 2 2 0 O-methyltransferase Methyltransf_32 PF13679.1 CCF32887.1 - 0.019 14.6 0.0 0.042 13.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.9 CCF32887.1 - 0.027 13.6 0.0 0.06 12.5 0.0 1.6 2 0 0 2 2 2 0 Tellurite resistance protein TehB Methyltransf_24 PF13578.1 CCF32887.1 - 0.029 15.1 0.1 0.12 13.2 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain PHBC_N PF12551.3 CCF32887.1 - 0.067 12.7 0.3 0.18 11.3 0.0 1.9 2 0 0 2 2 1 0 Poly-beta-hydroxybutyrate polymerase N terminal Transket_pyr PF02779.19 CCF32888.1 - 5.2e-46 156.3 0.0 6.9e-46 155.9 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 CCF32888.1 - 1.5e-35 121.8 0.1 4.6e-35 120.2 0.0 1.8 2 0 0 2 2 2 1 Transketolase, C-terminal domain Aminotran_5 PF00266.14 CCF32888.1 - 0.081 11.6 0.1 0.18 10.4 0.0 1.5 2 0 0 2 2 2 0 Aminotransferase class-V DSHCT PF08148.7 CCF32889.1 - 1.3e-61 206.9 0.4 2.3e-61 206.1 0.3 1.4 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 CCF32889.1 - 8.1e-21 74.2 0.0 1.9e-20 73.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF32889.1 - 3.6e-06 26.7 0.0 1.1e-05 25.1 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain rRNA_proc-arch PF13234.1 CCF32889.1 - 8.5e-06 25.1 2.5 0.00012 21.3 1.7 2.2 1 1 0 1 1 1 1 rRNA-processing arch domain ResIII PF04851.10 CCF32889.1 - 0.016 15.0 0.4 0.54 10.0 0.1 3.1 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Syntaxin PF00804.20 CCF32889.1 - 0.034 14.2 0.0 0.16 12.1 0.0 2.2 1 1 0 1 1 1 0 Syntaxin Cut8_C PF08559.5 CCF32889.1 - 0.059 13.1 0.1 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Cut8 six-helix bundle Snf7 PF03357.16 CCF32890.1 - 4e-08 32.8 26.2 4e-08 32.8 18.2 1.5 1 1 1 2 2 2 1 Snf7 Ist1 PF03398.9 CCF32890.1 - 0.0048 16.3 5.7 0.014 14.7 3.9 1.8 1 1 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway ASL_C PF08328.6 CCF32890.1 - 0.37 10.6 5.8 0.26 11.1 2.4 1.9 1 1 1 2 2 2 0 Adenylosuccinate lyase C-terminal Dynactin_p62 PF05502.8 CCF32890.1 - 0.93 8.1 12.4 0.98 8.1 8.6 1.1 1 0 0 1 1 1 0 Dynactin p62 family SATase_N PF06426.9 CCF32890.1 - 1.2 9.3 8.3 1.1 9.4 3.6 2.3 1 1 1 2 2 2 0 Serine acetyltransferase, N-terminal DUF1451 PF07295.6 CCF32890.1 - 2.6 7.8 10.5 0.49 10.1 3.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1451) DUF427 PF04248.7 CCF32891.1 - 9.6e-29 98.9 0.4 1.3e-28 98.4 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF427) TPPK_C PF12555.3 CCF32892.1 - 3.8 7.2 7.1 0.62 9.8 0.7 2.6 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal AAA PF00004.24 CCF32893.1 - 2.7e-11 43.7 0.0 5.8e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CCF32893.1 - 6.5e-07 29.5 0.0 1.9e-06 28.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 CCF32893.1 - 1.8e-05 24.4 0.0 3.6e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 CCF32893.1 - 5e-05 22.4 0.0 0.0001 21.4 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 CCF32893.1 - 0.00012 21.7 0.1 0.00056 19.6 0.0 2.2 2 0 0 2 2 2 1 Part of AAA domain Rad17 PF03215.10 CCF32893.1 - 0.00046 18.9 0.0 0.00073 18.3 0.0 1.2 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_14 PF13173.1 CCF32893.1 - 0.001 18.9 0.0 0.0021 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CCF32893.1 - 0.0029 18.4 0.1 0.011 16.5 0.0 2.2 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.1 CCF32893.1 - 0.0031 17.4 0.1 0.0096 15.7 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.1 CCF32893.1 - 0.0046 16.9 0.2 0.014 15.3 0.0 1.9 2 0 0 2 2 1 1 AAA ATPase domain Zeta_toxin PF06414.7 CCF32893.1 - 0.018 14.1 0.1 0.038 13.0 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin NTPase_1 PF03266.10 CCF32893.1 - 0.025 14.2 1.2 0.11 12.1 0.1 2.5 2 1 1 3 3 3 0 NTPase DUF258 PF03193.11 CCF32893.1 - 0.029 13.5 0.0 0.063 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NB-ARC PF00931.17 CCF32893.1 - 0.038 12.8 0.0 0.06 12.2 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain IstB_IS21 PF01695.12 CCF32893.1 - 0.053 12.9 0.2 0.19 11.0 0.1 1.9 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.1 CCF32893.1 - 0.068 13.4 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 CCF32893.1 - 0.068 12.5 0.2 1 8.7 0.1 2.4 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 CCF32893.1 - 0.082 13.1 0.0 0.25 11.6 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA_28 PF13521.1 CCF32893.1 - 0.089 12.7 0.0 0.36 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain HIT PF01230.18 CCF32894.1 - 5.4e-21 74.9 0.0 1e-20 74.0 0.0 1.4 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 CCF32894.1 - 0.00028 21.0 0.0 0.0007 19.8 0.0 1.6 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Ferrochelatase PF00762.14 CCF32895.1 - 6.3e-90 301.3 0.0 7.4e-90 301.1 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase Ku_N PF03731.10 CCF32896.1 - 8.2e-16 58.1 0.0 1.2e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain VWA_2 PF13519.1 CCF32896.1 - 0.13 12.3 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain HET PF06985.6 CCF32897.1 - 3.2e-07 30.6 4.2 7.6e-06 26.1 0.0 2.5 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Daxx PF03344.10 CCF32897.1 - 0.81 8.0 6.1 1.2 7.5 4.2 1.1 1 0 0 1 1 1 0 Daxx Family Nucleoplasmin PF03066.10 CCF32897.1 - 8.2 5.9 10.1 14 5.1 7.0 1.3 1 0 0 1 1 1 0 Nucleoplasmin MFS_1 PF07690.11 CCF32898.1 - 3.4e-40 137.8 28.8 3.4e-40 137.8 20.0 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF32898.1 - 7.7e-11 41.2 6.5 7.7e-11 41.2 4.5 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 CCF32898.1 - 0.00054 18.2 2.7 0.00082 17.6 1.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.15 CCF32898.1 - 0.11 10.5 3.6 0.038 12.0 0.3 1.8 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF4094 PF13334.1 CCF32898.1 - 4.3 7.8 5.5 7.4 7.0 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) RBP_receptor PF14752.1 CCF32899.1 - 0.076 11.3 0.0 0.076 11.3 0.0 1.0 1 0 0 1 1 1 0 Retinol binding protein receptor SecE PF00584.15 CCF32899.1 - 0.14 11.7 0.2 0.18 11.4 0.2 1.1 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex Zeta_toxin PF06414.7 CCF32900.1 - 8.2e-47 158.9 0.0 1.1e-46 158.5 0.0 1.1 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.1 CCF32900.1 - 1.2e-06 28.4 0.0 2e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.17 CCF32900.1 - 0.025 14.0 0.0 0.035 13.5 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_16 PF13191.1 CCF32900.1 - 0.03 14.3 0.0 0.064 13.2 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.13 CCF32900.1 - 0.061 12.7 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family T2SE PF00437.15 CCF32900.1 - 0.094 11.6 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Sigma54_activat PF00158.21 CCF32900.1 - 0.16 11.4 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_pol_I_A49 PF06870.7 CCF32901.1 - 6.1e-79 265.3 0.0 7e-79 265.1 0.0 1.1 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor HeH PF12949.2 CCF32902.1 - 2e-08 33.6 0.1 3.3e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 HeH/LEM domain Thymopoietin PF08198.6 CCF32902.1 - 0.054 13.0 0.0 0.086 12.3 0.0 1.3 1 0 0 1 1 1 0 Thymopoietin protein CENP-X PF09415.5 CCF32902.1 - 0.1 12.4 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 CENP-S associating Centromere protein X ABC_membrane PF00664.18 CCF32903.1 - 6e-89 298.1 25.9 1.3e-48 165.8 6.7 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 CCF32903.1 - 3.3e-51 173.1 0.0 6.9e-31 107.3 0.1 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 CCF32903.1 - 8.1e-10 38.3 4.1 0.0039 16.4 0.0 4.2 2 2 0 4 4 4 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.18 CCF32903.1 - 3.5e-05 23.7 0.0 0.32 10.9 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.1 CCF32903.1 - 3.7e-05 23.8 0.7 0.076 12.9 0.1 2.7 2 0 0 2 2 2 2 AAA ATPase domain Miro PF08477.8 CCF32903.1 - 0.0002 21.8 0.3 0.95 9.9 0.0 3.3 3 0 0 3 3 2 2 Miro-like protein AAA_23 PF13476.1 CCF32903.1 - 0.00031 21.1 1.6 0.073 13.3 0.1 3.3 3 1 0 3 3 3 1 AAA domain AAA_29 PF13555.1 CCF32903.1 - 0.00053 19.4 0.3 0.88 9.1 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.1 CCF32903.1 - 0.00074 19.5 0.0 2.6 7.9 0.0 4.1 4 0 0 4 4 4 1 AAA domain DUF258 PF03193.11 CCF32903.1 - 0.00076 18.6 0.1 0.66 9.1 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 UPF0093 PF03653.8 CCF32903.1 - 0.00086 19.2 1.3 0.0027 17.6 0.3 2.3 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0093) AAA_25 PF13481.1 CCF32903.1 - 0.002 17.5 0.0 0.92 8.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.13 CCF32903.1 - 0.0062 16.0 0.5 2.8 7.3 0.0 2.9 3 0 0 3 3 3 1 FtsK/SpoIIIE family Dynamin_N PF00350.18 CCF32903.1 - 0.0099 15.7 3.1 0.29 10.9 0.0 2.8 3 0 0 3 3 2 1 Dynamin family T2SE PF00437.15 CCF32903.1 - 0.011 14.6 0.1 0.16 10.8 0.1 2.4 2 1 0 2 2 2 0 Type II/IV secretion system protein RseC_MucC PF04246.7 CCF32903.1 - 0.026 14.0 0.2 0.3 10.6 0.0 2.9 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC DUF87 PF01935.12 CCF32903.1 - 0.067 12.9 3.5 0.81 9.4 0.1 2.7 3 0 0 3 3 2 0 Domain of unknown function DUF87 AAA_17 PF13207.1 CCF32903.1 - 0.11 13.3 0.4 5 7.9 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 CCF32903.1 - 0.27 10.6 1.8 8.2 5.7 0.0 2.6 2 1 0 2 2 2 0 AAA-like domain NACHT PF05729.7 CCF32903.1 - 0.3 10.7 1.5 0.73 9.4 0.1 2.3 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.1 CCF32903.1 - 0.41 10.7 2.2 25 5.0 0.1 3.3 2 1 0 2 2 2 0 AAA domain Pro-kuma_activ PF09286.6 CCF32904.1 - 0.13 12.3 0.0 0.14 12.2 0.0 1.1 1 0 0 1 1 1 0 Pro-kumamolisin, activation domain Ribosomal_L5_C PF00673.16 CCF32905.1 - 3.8e-21 74.6 0.0 5.7e-21 74.0 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 CCF32905.1 - 0.0045 16.7 0.0 0.0072 16.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L5 Fes1 PF08609.5 CCF32906.1 - 1.4e-31 108.8 3.4 1.4e-31 108.8 2.4 2.1 2 1 0 2 2 2 1 Nucleotide exchange factor Fes1 HEAT_2 PF13646.1 CCF32906.1 - 1.5e-08 34.7 1.1 0.00026 21.2 0.1 2.2 2 1 1 3 3 3 2 HEAT repeats HEAT_EZ PF13513.1 CCF32906.1 - 8.6e-06 26.0 0.9 0.00072 19.9 0.1 2.8 2 1 1 3 3 3 2 HEAT-like repeat HEAT PF02985.17 CCF32906.1 - 9.6e-05 22.1 0.1 0.016 15.2 0.0 2.7 2 0 0 2 2 2 1 HEAT repeat Arm PF00514.18 CCF32906.1 - 0.00091 18.9 0.0 0.12 12.1 0.0 2.6 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat Osmo_CC PF08946.5 CCF32906.1 - 0.13 12.2 1.1 2.5 8.1 0.1 2.5 2 0 0 2 2 2 0 Osmosensory transporter coiled coil Ala_racemase_N PF01168.15 CCF32908.1 - 0.041 13.4 0.0 0.06 12.9 0.0 1.2 1 0 0 1 1 1 0 Alanine racemase, N-terminal domain polyprenyl_synt PF00348.12 CCF32910.1 - 4.8e-39 133.7 0.0 1.4e-38 132.2 0.0 1.7 2 0 0 2 2 2 1 Polyprenyl synthetase Terpene_synth_C PF03936.11 CCF32910.1 - 2.6e-10 39.9 0.0 0.00028 20.1 0.0 3.2 3 0 0 3 3 3 2 Terpene synthase family, metal binding domain ANTAR PF03861.9 CCF32910.1 - 0.0021 17.5 0.6 0.0098 15.4 0.1 2.2 2 0 0 2 2 2 1 ANTAR domain CopK PF11525.3 CCF32910.1 - 0.069 12.7 1.2 0.19 11.4 0.8 1.7 1 0 0 1 1 1 0 Copper resistance protein K p450 PF00067.17 CCF32911.1 - 4.4e-51 173.8 0.0 5.9e-44 150.3 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 FACT-Spt16_Nlob PF14826.1 CCF32912.1 - 8.6e-10 38.3 0.0 1e-09 38.1 0.0 1.0 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain CMD PF02627.15 CCF32913.1 - 1.3e-10 41.0 0.1 1.8e-09 37.3 0.0 2.1 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family AlgF PF11182.3 CCF32913.1 - 0.1 12.2 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Alginate O-acetyl transferase AlgF Cytochrom_C PF00034.16 CCF32915.1 - 3.2 8.6 5.8 6 7.7 4.0 1.7 1 1 0 1 1 1 0 Cytochrome c CsbD PF05532.7 CCF32916.1 - 8e-18 63.8 18.2 7.7e-12 44.7 1.3 3.3 2 1 1 3 3 3 2 CsbD-like Aminotran_5 PF00266.14 CCF32917.1 - 4.4e-66 223.1 0.0 5e-66 222.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 CCF32917.1 - 1.4e-05 24.3 0.0 6.2e-05 22.1 0.0 1.8 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 CCF32917.1 - 7.5e-05 22.0 0.0 9.8e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Pyridoxal_deC PF00282.14 CCF32917.1 - 0.0025 16.3 0.0 0.0035 15.8 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain p450 PF00067.17 CCF32918.1 - 5e-27 94.5 0.0 6.7e-27 94.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 PIP49_N PF14875.1 CCF32918.1 - 0.13 11.8 0.1 0.22 11.1 0.1 1.3 1 0 0 1 1 1 0 N-term cysteine-rich ER, FAM69 Acyl_transf_3 PF01757.17 CCF32921.1 - 3.3e-38 131.4 29.5 3.9e-38 131.1 20.4 1.1 1 0 0 1 1 1 1 Acyltransferase family Gly_transf_sug PF04488.10 CCF32922.1 - 3.5e-11 43.4 2.1 5.7e-11 42.7 0.1 2.2 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif SARG PF15385.1 CCF32922.1 - 0.0031 16.9 4.8 0.0045 16.4 3.3 1.1 1 0 0 1 1 1 1 Specifically androgen-regulated gene protein T2SM PF04612.7 CCF32922.1 - 2.6 7.8 0.0 2.6 7.8 0.0 2.2 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M Pec_lyase_C PF00544.14 CCF32923.1 - 1.9e-38 131.9 5.0 3.7e-38 131.0 3.5 1.5 1 0 0 1 1 1 1 Pectate lyase IQ PF00612.22 CCF32926.1 - 1.6e-05 24.1 0.9 4.8e-05 22.6 0.6 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif SR-25 PF10500.4 CCF32926.1 - 0.0086 15.5 10.2 0.0086 15.5 7.1 3.3 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein SAS4 PF15460.1 CCF32927.1 - 2.2e-34 117.3 0.8 4.4e-34 116.3 0.1 1.9 2 0 0 2 2 2 1 Something about silencing, SAS, complex subunit 4 Adaptin_binding PF10199.4 CCF32927.1 - 0.0069 16.6 7.1 0.0069 16.6 4.9 2.2 2 1 1 3 3 3 1 Alpha and gamma adaptin binding protein p34 CDC45 PF02724.9 CCF32927.1 - 0.066 11.2 9.8 0.1 10.6 6.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.7 CCF32927.1 - 0.092 10.6 10.7 0.13 10.2 7.4 1.2 1 0 0 1 1 1 0 Nop14-like family HNOB PF07700.10 CCF32928.1 - 0.13 11.7 0.0 0.18 11.3 0.0 1.1 1 0 0 1 1 1 0 Heme NO binding Aconitase PF00330.15 CCF32930.1 - 1.3e-172 574.5 0.0 2.2e-172 573.7 0.0 1.4 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 CCF32930.1 - 2.7e-45 153.6 0.0 4.6e-45 152.9 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain zf-C2H2_jaz PF12171.3 CCF32932.1 - 1.9e-09 37.3 0.2 4.3e-09 36.2 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 CCF32932.1 - 0.003 17.6 1.5 0.38 10.8 0.1 2.1 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.1 CCF32932.1 - 0.023 14.6 0.1 0.043 13.7 0.1 1.5 1 1 0 1 1 1 0 C2H2-type zinc finger Spuma_A9PTase PF03539.9 CCF32932.1 - 0.03 14.2 0.2 0.037 13.9 0.1 1.1 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) DASH_Dam1 PF08653.5 CCF32933.1 - 6.8e-27 93.0 1.4 9.8e-27 92.5 1.0 1.2 1 0 0 1 1 1 1 DASH complex subunit Dam1 Prenyltrans_2 PF13249.1 CCF32935.1 - 7.3e-31 106.9 0.6 1.7e-12 47.6 0.0 3.9 1 1 3 4 4 4 4 Prenyltransferase-like Prenyltrans PF00432.16 CCF32935.1 - 3.3e-19 68.1 6.9 2e-11 43.2 0.1 3.9 4 0 0 4 4 4 3 Prenyltransferase and squalene oxidase repeat Prenyltrans_1 PF13243.1 CCF32935.1 - 5.8e-19 68.1 0.2 7.1e-13 48.5 0.1 4.4 2 1 3 5 5 5 4 Prenyltransferase-like Pec_lyase PF09492.5 CCF32935.1 - 0.00072 18.8 0.8 0.6 9.2 0.1 4.1 2 1 1 3 3 3 2 Pectic acid lyase A2M_comp PF07678.9 CCF32935.1 - 0.0014 17.8 0.0 0.1 11.8 0.0 3.0 2 1 1 3 3 3 1 A-macroglobulin complement component Cpn60_TCP1 PF00118.19 CCF32936.1 - 0.03 12.9 0.1 0.036 12.6 0.0 1.1 1 0 0 1 1 1 0 TCP-1/cpn60 chaperonin family Prenylcys_lyase PF07156.9 CCF32937.1 - 3.3e-33 115.1 0.0 3.1e-23 82.2 0.0 2.1 2 0 0 2 2 2 2 Prenylcysteine lyase NAD_binding_8 PF13450.1 CCF32937.1 - 3.5e-12 46.1 0.0 1.1e-11 44.5 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 CCF32937.1 - 9.9e-09 34.7 0.0 3.1e-08 33.1 0.0 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.19 CCF32937.1 - 4.9e-05 22.3 0.1 0.0001 21.3 0.0 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF32937.1 - 0.00018 21.4 0.6 0.31 10.9 0.2 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF32937.1 - 0.00025 20.8 0.2 0.0019 17.9 0.0 2.4 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 CCF32937.1 - 0.067 13.2 0.1 0.5 10.4 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF32937.1 - 0.096 11.7 0.1 0.17 10.9 0.1 1.3 1 0 0 1 1 1 0 Thi4 family VID27 PF08553.5 CCF32938.1 - 0 1126.4 0.2 0 1126.1 0.1 1.0 1 0 0 1 1 1 1 VID27 cytoplasmic protein Rav1p_C PF12234.3 CCF32938.1 - 0.066 11.3 0.0 0.16 10.1 0.0 1.6 1 0 0 1 1 1 0 RAVE protein 1 C terminal DUF666 PF05006.7 CCF32938.1 - 0.23 11.4 0.7 5.5 6.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF666) CDC45 PF02724.9 CCF32938.1 - 1.1 7.2 10.0 1.5 6.7 6.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Glyco_transf_20 PF00982.16 CCF32939.1 - 7.5e-32 110.4 0.2 8.8e-32 110.1 0.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Mrr_N PF14338.1 CCF32939.1 - 0.05 13.6 0.2 0.13 12.3 0.1 1.8 1 1 1 2 2 2 0 Mrr N-terminal domain Suf PF05843.9 CCF32940.1 - 0.00011 21.9 6.8 0.25 11.0 0.0 3.5 3 1 0 3 3 3 2 Suppressor of forked protein (Suf) TPR_14 PF13428.1 CCF32940.1 - 0.00047 20.5 1.9 6.1 7.7 0.0 6.3 6 2 2 8 8 8 1 Tetratricopeptide repeat TPR_16 PF13432.1 CCF32940.1 - 0.0034 18.0 0.4 2.6 8.8 0.0 4.1 4 1 1 5 5 5 1 Tetratricopeptide repeat HTS PF04204.11 CCF32940.1 - 3.6 6.2 10.0 0.73 8.5 2.3 2.2 2 0 0 2 2 2 0 Homoserine O-succinyltransferase Biotin_lipoyl PF00364.17 CCF32942.1 - 1.2e-18 66.4 0.9 2.6e-18 65.4 0.6 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 CCF32942.1 - 3.3e-07 29.8 0.1 1.3e-06 27.9 0.0 2.1 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.1 CCF32942.1 - 7.9e-05 22.2 0.0 0.00053 19.6 0.0 2.3 2 0 0 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.1 CCF32942.1 - 0.045 14.1 0.1 0.4 11.0 0.0 2.4 2 1 1 3 3 3 0 HlyD family secretion protein HlyD_2 PF12700.2 CCF32942.1 - 0.1 11.7 0.1 1.6 7.8 0.0 2.1 1 1 0 1 1 1 0 HlyD family secretion protein Methyltransf_23 PF13489.1 CCF32943.1 - 9.9e-20 70.8 0.0 1.4e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF32943.1 - 3.8e-11 42.8 0.0 5.6e-05 22.7 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.7 CCF32943.1 - 4.6e-10 39.8 0.0 1.1e-08 35.4 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF32943.1 - 1.5e-09 38.4 0.0 3.3e-08 34.0 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF32943.1 - 1.4e-06 28.5 0.0 5.4e-06 26.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF32943.1 - 1.1e-05 25.8 0.0 0.00017 22.0 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF32943.1 - 0.0043 16.4 0.0 0.0088 15.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 CCF32943.1 - 0.0075 15.4 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.13 CCF32943.1 - 0.013 14.6 0.0 0.55 9.2 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 CCF32943.1 - 0.031 13.3 0.0 0.12 11.4 0.0 1.8 2 1 0 2 2 2 0 Putative methyltransferase Methyltransf_26 PF13659.1 CCF32943.1 - 0.12 12.3 0.0 0.55 10.2 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain CoA_transf_3 PF02515.12 CCF32944.1 - 2.9e-26 91.8 0.4 8e-26 90.4 0.1 1.8 2 0 0 2 2 2 1 CoA-transferase family III Put_Phosphatase PF06888.7 CCF32947.1 - 0.031 13.4 0.0 0.033 13.3 0.0 1.0 1 0 0 1 1 1 0 Putative Phosphatase Aminotran_4 PF01063.14 CCF32949.1 - 9.6e-18 64.4 0.0 1.8e-17 63.6 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class IV Asp PF00026.18 CCF32950.1 - 4.7e-65 219.9 0.2 5.5e-65 219.6 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CCF32950.1 - 1.2e-07 31.7 0.0 9e-07 28.9 0.0 2.2 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 CCF32950.1 - 2.7e-05 24.5 0.4 0.11 12.9 0.1 2.6 2 1 0 2 2 2 2 Aspartyl protease Btz PF09405.5 CCF32951.1 - 4.3e-28 97.9 3.1 1e-27 96.7 2.2 1.6 1 0 0 1 1 1 1 CASC3/Barentsz eIF4AIII binding GNAT_acetyltr_2 PF13718.1 CCF32952.1 - 8.1e-80 266.7 0.0 1.4e-79 265.9 0.0 1.4 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.9 CCF32952.1 - 1.9e-66 223.0 0.0 6e-66 221.4 0.0 1.9 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.6 CCF32952.1 - 4.4e-40 135.2 0.1 1.3e-39 133.8 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) tRNA_bind_2 PF13725.1 CCF32952.1 - 1.4e-36 124.5 0.8 3.9e-36 123.1 0.6 1.7 1 0 0 1 1 1 1 Possible tRNA binding domain Acetyltransf_7 PF13508.1 CCF32952.1 - 0.0033 17.5 0.0 0.011 15.9 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF1713 PF08213.6 CCF32953.1 - 1.1e-12 47.2 22.3 1.1e-12 47.2 15.5 2.0 2 0 0 2 2 2 1 Mitochondrial domain of unknown function (DUF1713) Pet20 PF08692.5 CCF32953.1 - 0.0062 16.4 0.3 0.013 15.4 0.0 1.8 2 0 0 2 2 2 1 Mitochondrial protein Pet20 PhyH PF05721.8 CCF32954.1 - 3.1e-09 37.1 0.0 2.8e-08 34.0 0.0 2.3 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_3 PF13640.1 CCF32954.1 - 0.0057 17.1 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily NLPC_P60 PF00877.14 CCF32954.1 - 0.011 15.5 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 NlpC/P60 family Mpv17_PMP22 PF04117.7 CCF32955.1 - 1.3e-26 91.9 1.2 2.4e-26 91.1 0.8 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family HATPase_c PF02518.21 CCF32956.1 - 1.1e-28 99.1 0.1 2e-28 98.3 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 CCF32956.1 - 5e-23 80.8 0.1 1.6e-22 79.2 0.1 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.19 CCF32956.1 - 2.5e-22 79.0 0.2 5e-22 78.0 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain PAS_3 PF08447.6 CCF32956.1 - 9.2e-18 64.1 0.1 2.7e-17 62.6 0.1 1.9 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.1 CCF32956.1 - 6.3e-17 61.8 0.0 7.6e-12 45.5 0.0 3.2 3 0 0 3 3 3 2 PAS domain PAS_4 PF08448.5 CCF32956.1 - 8.5e-10 38.6 0.1 8.7e-06 25.7 0.0 3.7 3 2 0 3 3 3 2 PAS fold PAS PF00989.19 CCF32956.1 - 0.00029 20.5 0.0 0.053 13.3 0.0 2.9 2 0 0 2 2 2 1 PAS fold HATPase_c_3 PF13589.1 CCF32956.1 - 0.005 16.5 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_11 PF14598.1 CCF32956.1 - 0.027 14.4 0.0 0.056 13.4 0.0 1.5 1 0 0 1 1 1 0 PAS domain ABC_tran PF00005.22 CCF32957.1 - 2e-49 167.3 1.7 9.5e-30 103.6 0.0 3.1 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.18 CCF32957.1 - 2.6e-41 141.8 27.4 2.3e-24 86.2 3.4 3.6 4 0 0 4 4 3 2 ABC transporter transmembrane region SMC_N PF02463.14 CCF32957.1 - 1.1e-08 34.5 1.7 0.0065 15.7 0.4 4.1 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 CCF32957.1 - 4.5e-08 33.6 17.5 6.2e-05 23.4 0.0 3.8 4 0 0 4 4 3 2 AAA domain AAA_21 PF13304.1 CCF32957.1 - 2.4e-07 31.0 0.1 0.011 15.7 0.0 3.8 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.1 CCF32957.1 - 4.8e-06 26.0 0.2 0.1 12.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_10 PF12846.2 CCF32957.1 - 4.7e-05 22.9 0.1 0.061 12.7 0.0 3.2 2 1 0 3 3 3 1 AAA-like domain T2SE PF00437.15 CCF32957.1 - 5.6e-05 22.1 0.0 0.015 14.2 0.1 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_25 PF13481.1 CCF32957.1 - 5.6e-05 22.6 0.0 0.36 10.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 CCF32957.1 - 0.00059 19.9 0.0 2.7 8.1 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_17 PF13207.1 CCF32957.1 - 0.0017 19.1 4.9 1.9 9.3 0.0 3.8 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.18 CCF32957.1 - 0.0045 16.9 0.7 0.25 11.3 0.0 3.2 3 0 0 3 3 3 1 50S ribosome-binding GTPase DUF258 PF03193.11 CCF32957.1 - 0.0047 16.1 0.0 2.6 7.1 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 IstB_IS21 PF01695.12 CCF32957.1 - 0.009 15.4 0.0 0.81 9.0 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein Miro PF08477.8 CCF32957.1 - 0.013 15.9 0.4 5.8 7.4 0.0 2.8 2 0 0 2 2 2 0 Miro-like protein AAA_19 PF13245.1 CCF32957.1 - 0.016 14.9 0.6 4.3 7.1 0.1 3.6 2 1 0 2 2 2 0 Part of AAA domain AAA PF00004.24 CCF32957.1 - 0.017 15.3 0.3 8.3 6.6 0.0 3.5 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Borrelia_P83 PF05262.6 CCF32957.1 - 0.023 12.9 27.4 0.056 11.6 19.0 1.6 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF87 PF01935.12 CCF32957.1 - 0.032 14.0 0.0 0.032 14.0 0.0 3.7 4 0 0 4 4 3 0 Domain of unknown function DUF87 MobB PF03205.9 CCF32957.1 - 0.044 13.4 2.5 8.5 6.0 0.0 4.1 5 0 0 5 5 4 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 CCF32957.1 - 0.11 12.4 8.9 0.56 10.1 0.0 3.3 3 1 0 3 3 2 0 AAA ATPase domain AAA_11 PF13086.1 CCF32957.1 - 1 8.8 0.0 1 8.8 0.0 3.2 2 2 0 2 2 1 0 AAA domain AAA_18 PF13238.1 CCF32957.1 - 2.9 8.2 8.4 8.3 6.7 0.0 3.6 3 1 0 3 3 2 0 AAA domain Dynamin_N PF00350.18 CCF32957.1 - 3.5 7.4 8.4 8.3 6.2 0.0 3.4 3 0 0 3 3 3 0 Dynamin family Hid1 PF12722.2 CCF32957.1 - 5.6 4.5 5.9 7.9 4.0 4.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AAA_12 PF13087.1 CCF32958.1 - 1.7e-14 53.6 0.1 2.3e-14 53.2 0.1 1.2 1 0 0 1 1 1 1 AAA domain DUF2318 PF10080.4 CCF32958.1 - 0.039 13.7 0.6 0.039 13.7 0.4 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2318) zf-CCHC PF00098.18 CCF32958.1 - 0.063 13.2 1.5 0.063 13.2 1.1 2.9 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.1 CCF32958.1 - 0.19 11.3 9.8 0.58 9.8 1.0 2.9 3 0 0 3 3 3 0 Zinc knuckle C1_1 PF00130.17 CCF32958.1 - 0.47 10.2 10.4 0.041 13.6 3.7 1.8 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) MFS_1 PF07690.11 CCF32959.1 - 6.9e-26 90.7 18.4 1e-25 90.2 12.8 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.11 CCF32960.1 - 2e-42 145.2 40.5 2e-42 145.2 28.1 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF32960.1 - 1e-12 47.3 24.8 4.1e-12 45.4 9.6 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter NOA36 PF06524.7 CCF32961.1 - 0.067 12.4 0.3 0.086 12.0 0.2 1.1 1 0 0 1 1 1 0 NOA36 protein Fungal_trans PF04082.13 CCF32962.1 - 0.0082 15.0 0.7 0.035 12.9 0.5 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Ldh_1_N PF00056.18 CCF32963.1 - 4.9e-43 146.3 0.0 6.9e-43 145.8 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 CCF32963.1 - 3.3e-40 137.6 0.0 4.4e-40 137.2 0.0 1.1 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.14 CCF32963.1 - 2e-05 23.4 0.0 3.6e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.19 CCF32963.1 - 0.023 14.9 0.1 0.16 12.2 0.0 2.1 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_10 PF13460.1 CCF32963.1 - 0.086 12.8 0.1 0.2 11.6 0.1 1.6 1 1 0 1 1 1 0 NADH(P)-binding Iso_dh PF00180.15 CCF32964.1 - 6.8e-86 288.3 0.0 8.1e-86 288.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF3123 PF11321.3 CCF32965.1 - 0.086 13.1 4.6 0.22 11.7 0.4 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3123) Shadoo PF14999.1 CCF32965.1 - 0.22 11.3 4.2 0.19 11.5 1.3 1.9 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Cyclin_N PF00134.18 CCF32967.1 - 3.4e-10 39.5 0.1 5.4e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Palm_thioest PF02089.10 CCF32968.1 - 7.6e-53 179.2 0.0 9.6e-53 178.9 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.2 CCF32968.1 - 0.0001 22.2 0.0 0.00017 21.5 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Lipase_2 PF01674.13 CCF32968.1 - 0.0026 17.0 0.0 0.044 13.0 0.0 2.1 1 1 0 1 1 1 1 Lipase (class 2) DUF915 PF06028.6 CCF32968.1 - 0.0031 16.6 0.1 0.051 12.6 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_2 PF02230.11 CCF32968.1 - 0.18 11.2 0.3 7.9 5.8 0.2 2.2 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase Ribosomal_L1 PF00687.16 CCF32969.1 - 5.2e-61 205.8 1.0 5.2e-61 205.8 0.7 1.7 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family DPBB_1 PF03330.13 CCF32970.1 - 0.00065 19.6 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 Rare lipoprotein A (RlpA)-like double-psi beta-barrel DUF605 PF04652.11 CCF32970.1 - 0.34 10.2 21.8 0.4 10.0 15.1 1.1 1 0 0 1 1 1 0 Vta1 like DAO PF01266.19 CCF32971.1 - 7.6e-48 163.2 3.9 9.7e-48 162.8 2.7 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF32971.1 - 0.00052 19.9 0.2 0.0016 18.4 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF32971.1 - 0.0029 17.6 0.0 1.2 9.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CCF32971.1 - 0.051 13.4 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase eIF-5_eIF-2B PF01873.12 CCF32972.1 - 1.4e-44 150.7 0.9 2.1e-44 150.1 0.6 1.2 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Lar_restr_allev PF14354.1 CCF32972.1 - 0.037 14.3 0.1 0.12 12.6 0.1 1.9 1 0 0 1 1 1 0 Restriction alleviation protein Lar Arc_trans_TRASH PF08394.5 CCF32972.1 - 1 9.5 6.8 1.7 8.8 0.1 2.5 1 1 1 2 2 2 0 Archaeal TRASH domain zf-HYPF PF07503.7 CCF32972.1 - 4.5 6.7 5.5 6.5 6.2 2.3 2.5 2 1 1 3 3 3 0 HypF finger Glyco_hydro_47 PF01532.15 CCF32974.1 - 2.8e-166 553.6 0.0 4.6e-166 552.9 0.0 1.3 2 0 0 2 2 2 1 Glycosyl hydrolase family 47 DUF4038 PF13204.1 CCF32974.1 - 0.013 14.8 0.1 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4038) Autophagy_act_C PF03987.10 CCF32975.1 - 1.8e-10 40.8 0.0 3.1e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain RRM_5 PF13893.1 CCF32976.1 - 9.8e-11 41.3 0.0 1.4e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CCF32976.1 - 1.4e-09 37.4 0.0 3.9e-09 35.9 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF32976.1 - 2.2e-07 30.7 0.0 4.8e-07 29.6 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Calcipressin PF04847.7 CCF32976.1 - 0.00025 20.7 0.0 0.00038 20.0 0.0 1.3 1 0 0 1 1 1 1 Calcipressin Limkain-b1 PF11608.3 CCF32976.1 - 0.0035 17.0 0.2 0.0086 15.8 0.0 1.7 2 0 0 2 2 2 1 Limkain b1 MSP1_C PF07462.6 CCF32976.1 - 0.28 9.5 4.5 0.34 9.2 3.1 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus WD40 PF00400.27 CCF32977.1 - 3.1e-23 80.7 10.9 2.6e-08 33.4 0.0 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat Rax2 PF12768.2 CCF32977.1 - 0.0048 16.1 0.0 0.0093 15.2 0.0 1.4 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Gmad1 PF10647.4 CCF32977.1 - 0.11 11.9 1.1 4.4 6.6 0.0 2.5 2 1 1 3 3 3 0 Lipoprotein LpqB beta-propeller domain MFS_1 PF07690.11 CCF32978.1 - 3.8e-36 124.5 34.2 3.3e-35 121.4 19.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF32978.1 - 6e-15 54.7 10.0 6e-15 54.7 7.0 3.0 2 1 0 3 3 3 1 Sugar (and other) transporter adh_short_C2 PF13561.1 CCF32979.1 - 0.00012 21.9 0.0 0.00013 21.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltrn_RNA_3 PF02598.12 CCF32981.1 - 7e-81 271.7 0.0 8.1e-81 271.5 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase SpoU_methylase PF00588.14 CCF32981.1 - 0.012 15.4 0.0 3.4 7.5 0.0 2.3 2 0 0 2 2 2 0 SpoU rRNA Methylase family Thioredoxin PF00085.15 CCF32982.1 - 1.5e-26 92.1 0.1 2.2e-26 91.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 CCF32982.1 - 3.2e-07 30.3 0.0 9.6e-06 25.6 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.1 CCF32982.1 - 8.9e-07 29.0 0.3 3.4e-06 27.2 0.2 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.16 CCF32982.1 - 0.00076 19.1 0.0 0.0015 18.2 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_9 PF14595.1 CCF32982.1 - 0.0034 16.9 0.0 0.0048 16.4 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.5 CCF32982.1 - 0.0084 15.6 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.1 CCF32982.1 - 0.011 15.7 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like DUF2763 PF10961.3 CCF32982.1 - 0.013 15.8 0.1 0.038 14.3 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2763) HyaE PF07449.6 CCF32982.1 - 0.038 13.8 0.0 0.13 12.2 0.0 1.7 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_4 PF13462.1 CCF32982.1 - 0.1 12.6 0.3 1.1 9.2 0.0 2.0 1 1 1 2 2 2 0 Thioredoxin Rsm22 PF09243.5 CCF32983.1 - 4.9e-31 107.7 0.0 1.2e-30 106.4 0.0 1.6 1 1 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.1 CCF32983.1 - 0.00028 20.6 0.0 0.00073 19.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF32983.1 - 0.079 13.4 0.0 0.25 11.8 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.2 CCF32983.1 - 0.11 13.1 0.1 0.48 11.0 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 CCF32983.1 - 0.11 12.9 0.0 0.32 11.4 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain V_ATPase_I PF01496.14 CCF32983.1 - 2.5 5.8 3.9 3.6 5.3 2.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NAD_binding_7 PF13241.1 CCF32984.1 - 1.4e-07 31.7 0.0 1.6e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 Putative NAD(P)-binding DUF998 PF06197.8 CCF32985.1 - 0.013 14.7 2.2 0.032 13.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF998) HNH PF01844.18 CCF32986.1 - 5e-05 23.0 2.0 9e-05 22.2 1.4 1.4 1 0 0 1 1 1 1 HNH endonuclease zf-C2H2_4 PF13894.1 CCF32986.1 - 0.79 10.2 3.7 1.9 9.0 1.4 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger HAD_2 PF13419.1 CCF32987.1 - 2.5e-23 83.1 0.0 3.1e-23 82.8 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase D5_N PF08706.6 CCF32987.1 - 0.0014 18.7 0.0 0.0019 18.3 0.0 1.2 1 0 0 1 1 1 1 D5 N terminal like Hydrolase_like PF13242.1 CCF32987.1 - 0.0019 17.8 0.0 0.0031 17.1 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like DJ-1_PfpI PF01965.19 CCF32988.1 - 6.1e-08 32.2 0.1 2.3e-07 30.3 0.1 1.9 1 1 0 1 1 1 1 DJ-1/PfpI family DUF4066 PF13278.1 CCF32988.1 - 0.018 14.2 0.0 0.026 13.8 0.0 1.2 1 0 0 1 1 1 0 Putative amidotransferase S-methyl_trans PF02574.11 CCF32990.1 - 1.6e-22 80.2 0.0 2e-22 79.8 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase E1-E2_ATPase PF00122.15 CCF32993.1 - 2.2e-53 180.6 1.2 3.7e-53 179.9 0.1 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CCF32993.1 - 2.1e-35 121.9 5.1 2.1e-35 121.9 3.5 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CCF32993.1 - 6.9e-22 78.9 0.0 7.9e-21 75.4 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF32993.1 - 2.4e-13 49.8 0.0 5.2e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 CCF32993.1 - 1.6e-12 48.0 0.0 4.2e-12 46.6 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 CCF32993.1 - 9.7e-12 44.1 0.0 2.8e-11 42.6 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 CCF32993.1 - 0.0016 18.0 0.0 0.003 17.1 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2207 PF09972.4 CCF32993.1 - 0.16 10.5 3.4 2.9 6.3 0.0 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Sugar_tr PF00083.19 CCF32994.1 - 1e-16 60.5 2.8 1.2e-16 60.3 1.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF32994.1 - 0.00014 20.7 5.1 0.00014 20.7 3.5 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3684 PF12449.3 CCF32996.1 - 0 1419.7 0.0 0 1419.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.1 CCF32996.1 - 1.8e-05 24.4 0.0 4.8e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ANKH PF07260.6 CCF32997.1 - 0.022 13.7 0.0 0.026 13.5 0.0 1.0 1 0 0 1 1 1 0 Progressive ankylosis protein (ANKH) DUF3433 PF11915.3 CCF32998.1 - 5e-28 97.0 6.1 7.3e-17 61.3 0.1 4.1 4 0 0 4 4 4 2 Protein of unknown function (DUF3433) Ycf1 PF05758.7 CCF32998.1 - 0.7 7.5 3.0 1.1 6.8 2.1 1.2 1 0 0 1 1 1 0 Ycf1 DUF2077 PF09850.4 CCF32998.1 - 2 7.7 6.3 1.1 8.5 0.1 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2077) Ctr PF04145.10 CCF32999.1 - 4.6e-27 94.8 0.1 6.1e-27 94.4 0.1 1.2 1 0 0 1 1 1 1 Ctr copper transporter family Birna_VP4 PF01768.11 CCF32999.1 - 0.14 11.2 0.7 2.8 6.9 0.0 2.0 2 0 0 2 2 2 0 Birnavirus VP4 protein DUF4134 PF13572.1 CCF32999.1 - 4 7.6 6.0 5 7.3 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4134) BNR PF02012.15 CCF33000.1 - 9.9e-05 21.6 3.3 0.33 10.9 0.1 3.6 2 0 0 2 2 2 2 BNR/Asp-box repeat BNR_2 PF13088.1 CCF33000.1 - 0.0038 16.5 0.9 0.067 12.4 0.3 2.5 1 1 2 3 3 3 1 BNR repeat-like domain DUF4185 PF13810.1 CCF33000.1 - 0.0068 15.3 3.0 0.02 13.7 0.2 2.4 1 1 1 2 2 2 1 Domain of unknown function (DUF4185) Thioredox_DsbH PF03190.10 CCF33000.1 - 0.076 12.7 0.1 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Macoilin PF09726.4 CCF33001.1 - 0.0093 14.3 3.9 0.0099 14.2 2.7 1.1 1 0 0 1 1 1 1 Transmembrane protein ABC_tran_2 PF12848.2 CCF33001.1 - 0.047 13.5 5.3 0.076 12.8 3.7 1.4 1 0 0 1 1 1 0 ABC transporter FlaC_arch PF05377.6 CCF33001.1 - 0.067 13.0 0.4 0.11 12.4 0.3 1.3 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF641 PF04859.7 CCF33001.1 - 0.11 12.2 2.5 0.15 11.7 1.7 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF4337 PF14235.1 CCF33001.1 - 0.36 10.6 7.2 0.5 10.1 5.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) V_ATPase_I PF01496.14 CCF33001.1 - 0.37 8.5 2.6 0.39 8.5 1.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tho2 PF11262.3 CCF33001.1 - 1.3 7.9 5.6 1.7 7.6 3.9 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 bZIP_Maf PF03131.12 CCF33001.1 - 2 8.7 10.5 3.7 7.9 7.2 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF4407 PF14362.1 CCF33001.1 - 2.1 7.2 7.0 2.5 7.0 4.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Bap31 PF05529.7 CCF33001.1 - 2.2 7.6 6.5 3.1 7.1 4.5 1.2 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like NACHT PF05729.7 CCF33002.1 - 1.9e-13 50.3 0.0 5.7e-13 48.8 0.0 1.9 1 0 0 1 1 1 1 NACHT domain HEAT_2 PF13646.1 CCF33002.1 - 3.6e-11 43.1 0.2 1.1e-10 41.5 0.1 1.8 1 0 0 1 1 1 1 HEAT repeats HEAT PF02985.17 CCF33002.1 - 8.5e-08 31.6 0.1 0.022 14.8 0.1 2.8 2 0 0 2 2 2 2 HEAT repeat HEAT_EZ PF13513.1 CCF33002.1 - 1.4e-05 25.4 0.0 0.025 15.0 0.0 2.9 2 0 0 2 2 2 2 HEAT-like repeat NB-ARC PF00931.17 CCF33002.1 - 0.00019 20.4 0.0 0.00042 19.2 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.1 CCF33002.1 - 0.00021 21.4 0.0 0.0084 16.2 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_17 PF13207.1 CCF33002.1 - 0.00052 20.8 0.0 0.0022 18.7 0.0 2.2 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.1 CCF33002.1 - 0.0012 18.8 0.0 0.0052 16.7 0.0 2.2 2 0 0 2 2 1 1 AAA ATPase domain AAA_19 PF13245.1 CCF33002.1 - 0.0083 15.8 0.0 0.025 14.3 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain NTPase_1 PF03266.10 CCF33002.1 - 0.017 14.8 0.0 0.04 13.6 0.0 1.6 1 0 0 1 1 1 0 NTPase AAA PF00004.24 CCF33002.1 - 0.022 14.9 0.0 0.092 12.9 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 CCF33002.1 - 0.024 14.9 0.0 0.061 13.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain Vac14_Fab1_bd PF12755.2 CCF33002.1 - 0.043 14.2 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region MobB PF03205.9 CCF33002.1 - 0.054 13.2 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 CCF33002.1 - 0.075 12.9 0.0 0.24 11.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain HEAT_PBS PF03130.11 CCF33002.1 - 0.12 12.9 0.0 19 6.0 0.0 2.9 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat NACHT PF05729.7 CCF33003.1 - 4.8e-18 65.3 0.0 8e-18 64.6 0.0 1.3 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.17 CCF33003.1 - 5.8e-08 31.9 0.0 1.2e-07 30.9 0.0 1.4 1 1 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.1 CCF33003.1 - 2.9e-06 27.4 0.5 1.9e-05 24.8 0.4 2.1 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CCF33003.1 - 7.8e-06 26.2 0.0 1.7e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CCF33003.1 - 3.4e-05 24.6 1.2 0.00013 22.8 0.2 2.2 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.1 CCF33003.1 - 8.1e-05 22.5 0.1 0.00022 21.1 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF33003.1 - 0.002 18.1 0.8 0.15 11.9 0.0 2.3 1 1 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.1 CCF33003.1 - 0.0032 16.9 0.0 0.0065 15.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 CCF33003.1 - 0.0064 15.9 0.1 0.86 8.9 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA PF00004.24 CCF33003.1 - 0.012 15.8 0.0 0.024 14.8 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.10 CCF33003.1 - 0.015 15.0 0.2 0.03 14.0 0.1 1.5 1 0 0 1 1 1 0 NTPase ABC_tran PF00005.22 CCF33003.1 - 0.018 15.3 0.0 0.031 14.5 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_19 PF13245.1 CCF33003.1 - 0.02 14.6 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain DAP3 PF10236.4 CCF33003.1 - 0.05 12.5 0.0 2.1 7.1 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 RNA_helicase PF00910.17 CCF33003.1 - 0.052 13.7 0.0 0.15 12.2 0.0 1.7 2 0 0 2 2 2 0 RNA helicase AAA_24 PF13479.1 CCF33003.1 - 0.054 13.0 0.0 0.13 11.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain DNA_alkylation PF08713.6 CCF33003.1 - 0.058 12.8 0.1 0.16 11.4 0.0 1.6 2 0 0 2 2 2 0 DNA alkylation repair enzyme MobB PF03205.9 CCF33003.1 - 0.078 12.6 0.1 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B PduV-EutP PF10662.4 CCF33003.1 - 0.1 12.0 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Sigma54_activat PF00158.21 CCF33003.1 - 0.13 11.6 0.0 1.4 8.3 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain Nucleos_tra2_N PF01773.15 CCF33004.1 - 1.2e-13 51.1 0.1 2.8e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 Na+ dependent nucleoside transporter N-terminus Sugar_tr PF00083.19 CCF33005.1 - 1.2e-67 228.5 28.1 1.3e-67 228.3 19.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF33005.1 - 3.9e-21 75.1 34.7 5.2e-20 71.4 22.0 2.6 2 1 0 3 3 3 2 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF33005.1 - 0.016 14.9 7.7 0.27 11.0 0.1 3.9 4 0 0 4 4 4 0 MFS_1 like family Pkinase PF00069.20 CCF33006.1 - 4.5e-13 48.9 0.0 5.9e-12 45.2 0.0 2.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF33006.1 - 7.4e-10 38.3 0.0 6.9e-09 35.1 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pyr_redox_3 PF13738.1 CCF33006.1 - 0.093 12.7 0.3 0.21 11.6 0.2 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pkinase PF00069.20 CCF33007.1 - 7.1e-05 22.0 0.0 0.00012 21.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Chordopox_A33R PF05966.7 CCF33009.1 - 0.082 11.6 0.0 0.099 11.4 0.0 1.2 1 0 0 1 1 1 0 Chordopoxvirus A33R protein BSP_II PF05432.6 CCF33011.1 - 0.055 12.7 11.0 0.071 12.3 7.6 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Methyltransf_23 PF13489.1 CCF33014.1 - 2.9e-14 53.1 0.0 4.8e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF33014.1 - 3.5e-06 27.5 0.0 0.0021 18.6 0.0 2.3 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.7 CCF33014.1 - 0.00016 22.1 0.0 0.038 14.4 0.0 2.4 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF33014.1 - 0.0046 17.4 0.0 1.4 9.4 0.0 2.5 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF33014.1 - 0.0058 16.2 0.0 0.22 11.0 0.0 2.1 1 1 1 2 2 2 1 Methyltransferase domain MTS PF05175.9 CCF33014.1 - 0.0092 15.3 0.0 0.048 13.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain PHY PF00360.15 CCF33014.1 - 0.12 11.5 0.1 3.4 6.7 0.0 2.5 3 0 0 3 3 3 0 Phytochrome region DUF3445 PF11927.3 CCF33016.1 - 1.6e-69 234.0 0.0 2e-69 233.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Amidohydro_4 PF13147.1 CCF33017.1 - 7.3e-13 49.1 3.1 6.5e-08 32.9 0.0 3.6 3 0 0 3 3 3 3 Amidohydrolase Amidohydro_5 PF13594.1 CCF33017.1 - 2.1e-07 30.6 1.2 4e-06 26.5 0.1 2.9 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_1 PF01979.15 CCF33017.1 - 5.1e-07 29.6 1.2 8.8e-06 25.5 0.0 3.0 3 1 0 3 3 3 1 Amidohydrolase family Amidohydro_3 PF07969.6 CCF33017.1 - 4e-05 23.0 0.1 0.00018 20.8 0.0 2.1 2 0 0 2 2 2 1 Amidohydrolase family NCA2 PF08637.5 CCF33019.1 - 8.2e-86 287.4 0.0 1.2e-85 286.9 0.0 1.2 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 TMEM171 PF15471.1 CCF33019.1 - 0.18 10.5 0.1 0.29 9.9 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 Ras PF00071.17 CCF33020.1 - 1.6e-64 216.1 0.0 1.9e-64 215.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF33020.1 - 1.4e-19 70.7 0.0 1.9e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CCF33020.1 - 3.7e-13 49.0 0.0 4.1e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 CCF33020.1 - 2.5e-06 27.0 0.0 4.5e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 CCF33020.1 - 8.1e-06 25.1 0.0 8.7e-06 25.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 CCF33020.1 - 0.0044 16.9 0.0 0.0063 16.4 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 CCF33020.1 - 0.023 13.8 0.0 0.028 13.6 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit FeoB_N PF02421.13 CCF33020.1 - 0.049 12.9 0.0 0.23 10.7 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B DUF258 PF03193.11 CCF33020.1 - 0.082 12.0 0.0 0.19 10.8 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 CCF33020.1 - 0.097 12.2 0.0 0.25 10.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.1 CCF33020.1 - 0.11 12.6 0.0 0.27 11.3 0.0 1.9 1 1 1 2 2 2 0 AAA domain G-alpha PF00503.15 CCF33020.1 - 0.12 11.0 0.4 13 4.2 0.0 2.7 1 1 1 2 2 2 0 G-protein alpha subunit DUF1631 PF07793.6 CCF33021.1 - 1.7 6.6 4.2 2.6 6.0 2.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) AAA PF00004.24 CCF33022.1 - 2.7e-53 179.6 0.0 6.3e-40 136.4 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF33022.1 - 8.1e-07 29.2 0.1 0.011 15.6 0.0 3.5 2 1 0 3 3 3 2 AAA ATPase domain AAA_25 PF13481.1 CCF33022.1 - 2e-06 27.3 3.2 0.01 15.2 0.1 3.7 2 2 2 4 4 4 1 AAA domain AAA_5 PF07728.9 CCF33022.1 - 2.8e-06 27.1 0.1 0.06 13.0 0.0 3.5 3 1 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 CCF33022.1 - 5.8e-06 26.2 0.0 0.018 14.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain Vps4_C PF09336.5 CCF33022.1 - 0.00013 21.7 0.0 0.12 12.3 0.0 2.9 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_22 PF13401.1 CCF33022.1 - 0.0002 21.5 2.5 9.9 6.3 1.3 4.3 2 2 1 4 4 4 0 AAA domain AAA_28 PF13521.1 CCF33022.1 - 0.00029 20.8 0.0 0.03 14.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain CDC48_N PF02359.13 CCF33022.1 - 0.00076 19.3 0.0 0.0068 16.3 0.0 2.4 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain AAA_19 PF13245.1 CCF33022.1 - 0.00089 18.9 0.3 1.1 9.0 0.0 3.5 3 1 0 3 3 3 1 Part of AAA domain RuvB_N PF05496.7 CCF33022.1 - 0.0068 15.4 0.0 0.026 13.5 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 CCF33022.1 - 0.011 15.6 0.0 0.26 11.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 CCF33022.1 - 0.012 15.7 0.0 9.3 6.4 0.0 2.9 2 0 0 2 2 2 0 RNA helicase DUF2075 PF09848.4 CCF33022.1 - 0.028 13.3 0.2 2.8 6.8 0.1 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) DUF815 PF05673.8 CCF33022.1 - 0.03 13.2 0.0 0.11 11.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_17 PF13207.1 CCF33022.1 - 0.041 14.6 0.0 0.37 11.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.1 CCF33022.1 - 0.049 13.6 0.0 3.9 7.5 0.0 2.8 2 1 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.12 CCF33022.1 - 0.05 13.0 0.2 8.4 5.7 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein Torsin PF06309.6 CCF33022.1 - 0.065 13.1 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Torsin DAP3 PF10236.4 CCF33022.1 - 0.15 10.9 0.0 0.56 9.0 0.0 1.9 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 SE PF08491.5 CCF33023.1 - 4.2e-87 291.4 0.0 5.1e-87 291.2 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase DAO PF01266.19 CCF33023.1 - 4.5e-10 38.9 1.3 2.9e-07 29.7 0.8 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 CCF33023.1 - 2.1e-09 36.9 0.9 2.7e-08 33.2 0.6 2.3 1 1 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 CCF33023.1 - 2.9e-05 23.2 0.0 4.4e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.17 CCF33023.1 - 0.00011 21.1 0.3 0.00035 19.5 0.2 1.7 1 1 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.1 CCF33023.1 - 0.00016 21.6 0.5 0.00042 20.2 0.4 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CCF33023.1 - 0.00083 18.3 0.4 0.0013 17.6 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.7 CCF33023.1 - 0.0024 16.8 0.1 0.046 12.6 0.0 2.3 2 0 0 2 2 2 1 Lycopene cyclase protein ApbA PF02558.11 CCF33023.1 - 0.0032 16.9 0.2 0.0056 16.1 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.15 CCF33023.1 - 0.0033 17.5 0.0 0.007 16.4 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.9 CCF33023.1 - 0.0042 16.9 0.5 0.0082 16.0 0.3 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF33023.1 - 0.0061 16.9 0.5 0.015 15.7 0.1 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 CCF33023.1 - 0.0062 15.6 0.4 0.011 14.8 0.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase 3HCDH_N PF02737.13 CCF33023.1 - 0.0088 15.7 0.1 0.018 14.6 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.18 CCF33023.1 - 0.012 15.3 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus HI0933_like PF03486.9 CCF33023.1 - 0.079 11.4 0.1 0.11 10.8 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein F-box-like PF12937.2 CCF33025.1 - 0.034 13.8 1.2 0.28 10.9 0.2 2.4 2 0 0 2 2 2 0 F-box-like Myb_DNA-bind_6 PF13921.1 CCF33025.1 - 0.035 14.1 0.1 0.11 12.6 0.1 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain VGCC_alpha2 PF08473.6 CCF33025.1 - 0.081 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Neuronal voltage-dependent calcium channel alpha 2acd Pyridox_oxidase PF01243.15 CCF33026.1 - 1.5e-09 37.7 0.0 3.4e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Gp-FAR-1 PF05823.7 CCF33026.1 - 0.12 12.3 0.3 1.6 8.7 0.0 2.1 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) TP_methylase PF00590.15 CCF33027.1 - 1.1e-20 74.2 0.1 1.8e-20 73.5 0.1 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DnaJ PF00226.26 CCF33028.1 - 4.3e-24 84.0 5.3 8.1e-24 83.1 3.6 1.5 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 CCF33028.1 - 2.8e-21 75.2 0.1 2.5e-18 65.7 0.0 2.7 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 CCF33028.1 - 5.4e-13 48.7 16.5 8.7e-13 48.1 11.4 1.3 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 CCF33028.1 - 0.011 15.4 7.1 0.19 11.4 0.9 2.3 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family NMDAR2_C PF10565.4 CCF33028.1 - 0.066 11.8 0.3 0.082 11.5 0.2 1.1 1 0 0 1 1 1 0 N-methyl D-aspartate receptor 2B3 C-terminus zf-CHY PF05495.7 CCF33028.1 - 5.2 7.2 10.6 6.1 7.0 0.9 2.3 1 1 0 2 2 2 0 CHY zinc finger tRNA-synt_1c PF00749.16 CCF33029.1 - 3.1e-93 311.8 0.0 4.1e-93 311.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain TPR_11 PF13414.1 CCF33030.1 - 7.8e-22 76.7 8.3 1.7e-11 43.5 0.1 3.3 1 1 2 3 3 3 3 TPR repeat TPR_1 PF00515.23 CCF33030.1 - 5.7e-19 66.8 7.1 5.8e-09 35.1 0.0 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.12 CCF33030.1 - 1.3e-16 59.0 6.2 1.1e-06 28.1 0.0 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.1 CCF33030.1 - 1.6e-14 53.5 0.2 3.6e-08 33.2 0.0 2.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 CCF33030.1 - 1.6e-12 46.2 2.5 7.4e-06 25.3 0.0 4.6 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.1 CCF33030.1 - 4e-09 35.5 0.2 6.7e-07 28.6 0.0 3.5 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 CCF33030.1 - 8.3e-09 35.3 0.4 0.089 13.2 0.0 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 CCF33030.1 - 2.9e-07 30.1 0.4 0.0027 17.7 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat PB1 PF00564.19 CCF33030.1 - 3.7e-07 29.7 0.1 7.1e-07 28.8 0.1 1.4 1 0 0 1 1 1 1 PB1 domain TPR_16 PF13432.1 CCF33030.1 - 1.3e-05 25.7 0.3 0.00086 19.9 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 CCF33030.1 - 1.7e-05 24.5 0.2 0.47 10.3 0.0 3.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.1 CCF33030.1 - 0.00049 20.4 0.1 0.022 15.3 0.0 3.3 1 1 2 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 CCF33030.1 - 0.0037 17.3 2.1 0.015 15.4 0.1 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 CCF33030.1 - 0.018 15.3 0.1 0.16 12.3 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3808 PF10300.4 CCF33030.1 - 0.067 11.7 0.0 0.11 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) TPR_4 PF07721.9 CCF33030.1 - 0.075 13.5 0.0 36 5.1 0.0 3.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.1 CCF33030.1 - 0.13 12.2 0.1 5.9 6.9 0.0 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat Cpn60_TCP1 PF00118.19 CCF33032.1 - 3.6e-118 395.2 9.2 4.1e-118 395.0 6.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF1547 PF07577.6 CCF33032.1 - 0.076 12.6 0.3 0.27 10.9 0.2 1.9 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1547) Cofilin_ADF PF00241.15 CCF33033.1 - 2.2e-34 118.0 0.6 2.5e-34 117.8 0.5 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SpoVR PF04293.8 CCF33033.1 - 0.028 12.8 0.0 0.037 12.3 0.0 1.2 1 0 0 1 1 1 0 SpoVR like protein FYRC PF05965.9 CCF33033.1 - 0.076 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 F/Y rich C-terminus Blt1 PF12754.2 CCF33034.1 - 2.3e-34 119.4 4.2 1.1e-30 107.3 0.7 2.2 1 1 1 2 2 2 2 Cell-cycle control medial ring component ubiquitin PF00240.18 CCF33034.1 - 2.9e-06 26.5 0.1 4.9e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 CCF33034.1 - 0.019 14.6 0.2 0.031 13.9 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Nol1_Nop2_Fmu PF01189.12 CCF33035.1 - 1.7e-59 201.5 0.0 3.7e-59 200.4 0.0 1.5 2 0 0 2 2 2 1 NOL1/NOP2/sun family PCMT PF01135.14 CCF33035.1 - 0.0081 15.7 0.0 0.013 15.0 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.14 CCF33035.1 - 0.023 14.6 0.0 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_18 PF12847.2 CCF33035.1 - 0.03 14.8 0.1 0.12 13.0 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.1 CCF33035.1 - 0.034 13.7 0.0 0.11 12.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain WD40 PF00400.27 CCF33037.1 - 2.7e-20 71.4 0.5 6.7e-06 25.7 0.0 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat EIF_2_alpha PF07541.7 CCF33038.1 - 4.3e-38 129.5 0.0 9.1e-38 128.4 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.18 CCF33038.1 - 2.3e-13 50.0 0.9 4.9e-13 48.9 0.6 1.6 1 0 0 1 1 1 1 S1 RNA binding domain adh_short PF00106.20 CCF33039.1 - 0.0007 19.5 0.0 0.00089 19.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF33039.1 - 0.056 13.0 0.0 0.075 12.6 0.0 1.1 1 0 0 1 1 1 0 KR domain Aldo_ket_red PF00248.16 CCF33041.1 - 2.7e-53 180.6 0.0 3.2e-53 180.3 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Exotox-A_cataly PF09009.5 CCF33041.1 - 0.11 11.4 0.0 0.2 10.4 0.0 1.4 1 0 0 1 1 1 0 Exotoxin A catalytic HIT PF01230.18 CCF33042.1 - 5.4e-18 65.3 0.0 9.5e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 CCF33042.1 - 1.4e-07 31.7 0.0 3e-07 30.6 0.0 1.5 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.10 CCF33042.1 - 2.2e-05 24.0 0.0 5.7e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 DNA_RNApol_7kD PF03604.8 CCF33043.1 - 2.2e-15 55.8 7.8 2.7e-15 55.5 5.4 1.1 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit HypA PF01155.14 CCF33043.1 - 0.0037 16.9 0.3 0.0037 16.9 0.2 1.1 1 0 0 1 1 1 1 Hydrogenase expression/synthesis hypA family GATA PF00320.22 CCF33043.1 - 0.004 16.4 3.5 0.004 16.4 0.0 2.2 2 1 0 2 2 2 1 GATA zinc finger GFA PF04828.9 CCF33043.1 - 0.0053 16.6 1.1 1.9 8.4 0.3 2.1 1 1 1 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.2 CCF33043.1 - 0.025 14.3 1.5 0.036 13.8 1.0 1.2 1 0 0 1 1 1 0 Double zinc ribbon FYDLN_acid PF09538.5 CCF33043.1 - 0.1 13.2 0.5 0.13 12.8 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Zn_Tnp_IS1595 PF12760.2 CCF33043.1 - 0.12 12.1 2.6 0.81 9.5 0.2 2.2 2 1 0 2 2 2 0 Transposase zinc-ribbon domain Prok-RING_1 PF14446.1 CCF33043.1 - 0.14 11.9 1.5 0.2 11.3 1.0 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-ISL3 PF14690.1 CCF33043.1 - 0.19 11.7 0.7 0.19 11.7 0.5 1.9 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Zn_ribbon_recom PF13408.1 CCF33043.1 - 0.2 11.9 2.9 4.9 7.4 0.5 2.2 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain Zn-ribbon_8 PF09723.5 CCF33043.1 - 0.28 11.1 4.5 0.87 9.5 3.1 1.8 1 1 0 1 1 1 0 Zinc ribbon domain A2L_zn_ribbon PF08792.5 CCF33043.1 - 0.46 10.0 4.2 5 6.6 0.2 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain TFIIS_C PF01096.13 CCF33043.1 - 1.7 8.3 5.0 11 5.7 0.0 2.7 2 1 1 3 3 3 0 Transcription factor S-II (TFIIS) TF_Zn_Ribbon PF08271.7 CCF33043.1 - 2.4 7.5 7.2 1.8 7.9 0.1 2.1 1 1 1 2 2 2 0 TFIIB zinc-binding ATP_bind_1 PF03029.12 CCF33044.1 - 2e-76 256.6 0.0 2.7e-76 256.2 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.18 CCF33044.1 - 2.5e-05 24.1 0.0 6.4e-05 22.8 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CCF33044.1 - 5.8e-05 22.5 0.0 0.0028 17.1 0.0 2.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 CCF33044.1 - 9.9e-05 23.1 1.2 0.00071 20.3 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CCF33044.1 - 0.00016 21.7 0.0 0.00065 19.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 CCF33044.1 - 0.00017 22.0 0.0 1 9.8 0.0 2.8 3 0 0 3 3 2 2 Miro-like protein Zeta_toxin PF06414.7 CCF33044.1 - 0.00046 19.3 0.0 0.00097 18.2 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_10 PF12846.2 CCF33044.1 - 0.00085 18.8 0.9 0.0035 16.8 0.6 2.0 1 1 0 1 1 1 1 AAA-like domain AAA_16 PF13191.1 CCF33044.1 - 0.00095 19.1 0.0 0.0021 18.0 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 CCF33044.1 - 0.0013 18.6 0.2 0.0099 15.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain PRK PF00485.13 CCF33044.1 - 0.0018 17.9 0.0 0.0094 15.5 0.0 2.0 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family NACHT PF05729.7 CCF33044.1 - 0.0018 17.9 0.0 0.0035 17.0 0.0 1.4 1 0 0 1 1 1 1 NACHT domain G-alpha PF00503.15 CCF33044.1 - 0.0023 16.6 0.1 0.14 10.7 0.0 2.5 3 0 0 3 3 3 1 G-protein alpha subunit SRP54 PF00448.17 CCF33044.1 - 0.0039 16.6 0.0 0.023 14.1 0.0 2.2 3 0 0 3 3 2 1 SRP54-type protein, GTPase domain AAA_30 PF13604.1 CCF33044.1 - 0.0048 16.5 0.0 0.01 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain cobW PF02492.14 CCF33044.1 - 0.0049 16.3 0.1 0.072 12.5 0.1 2.4 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 CCF33044.1 - 0.0054 15.5 0.1 0.95 8.1 0.0 2.5 2 1 0 2 2 2 1 ArgK protein LcrG PF07216.7 CCF33044.1 - 0.0075 16.2 0.4 0.014 15.3 0.2 1.4 1 0 0 1 1 1 1 LcrG protein NB-ARC PF00931.17 CCF33044.1 - 0.0077 15.1 0.0 0.017 13.9 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain MobB PF03205.9 CCF33044.1 - 0.0079 15.8 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B FeoB_N PF02421.13 CCF33044.1 - 0.0095 15.2 0.1 0.14 11.4 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.16 CCF33044.1 - 0.014 14.6 0.0 2.3 7.4 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_24 PF13479.1 CCF33044.1 - 0.02 14.5 0.0 0.042 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Ras PF00071.17 CCF33044.1 - 0.031 13.6 0.0 2.8 7.3 0.0 2.7 2 1 0 2 2 2 0 Ras family SRPRB PF09439.5 CCF33044.1 - 0.054 12.6 0.4 7.5 5.7 0.0 2.7 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit AAA_18 PF13238.1 CCF33044.1 - 0.058 13.6 0.0 0.058 13.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.1 CCF33044.1 - 0.061 13.6 0.0 1.2 9.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 CCF33044.1 - 0.077 12.7 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain AAA_14 PF13173.1 CCF33044.1 - 0.077 12.8 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 CCF33044.1 - 0.081 12.6 0.1 0.26 10.9 0.0 1.8 2 0 0 2 2 2 0 Archaeal ATPase T2SE PF00437.15 CCF33044.1 - 0.093 11.6 0.0 0.17 10.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Pox_A32 PF04665.7 CCF33044.1 - 0.12 11.6 0.5 0.56 9.4 0.0 2.2 3 0 0 3 3 2 0 Poxvirus A32 protein FtsK_SpoIIIE PF01580.13 CCF33044.1 - 0.12 11.7 1.2 0.73 9.2 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family KAP_NTPase PF07693.9 CCF33044.1 - 0.14 11.1 0.0 0.21 10.5 0.0 1.6 1 1 0 1 1 1 0 KAP family P-loop domain Viral_helicase1 PF01443.13 CCF33044.1 - 0.15 11.5 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Motilin_ghrelin PF04644.7 CCF33044.1 - 0.26 11.1 8.8 0.49 10.2 6.1 1.3 1 0 0 1 1 1 0 Motilin/ghrelin CwfJ_C_1 PF04677.10 CCF33045.1 - 1.2e-27 95.9 0.0 2e-27 95.2 0.0 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.9 CCF33045.1 - 1.4e-21 76.8 0.0 6.8e-21 74.6 0.0 2.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 DUF1777 PF08648.7 CCF33045.1 - 0.00032 20.4 53.4 0.00032 20.4 37.0 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF1777) PAP_assoc PF03828.14 CCF33047.1 - 6.9e-19 67.5 0.1 1.5e-18 66.4 0.1 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 CCF33047.1 - 2.6e-07 30.8 0.0 4.7e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain VHS PF00790.14 CCF33049.1 - 2.4e-23 82.3 0.0 4e-23 81.6 0.0 1.3 1 0 0 1 1 1 1 VHS domain GAT PF03127.9 CCF33049.1 - 1.7e-08 34.3 0.3 3.7e-08 33.2 0.2 1.5 1 0 0 1 1 1 1 GAT domain Period_C PF12114.3 CCF33049.1 - 1.2 8.6 7.3 2.1 7.9 5.1 1.3 1 0 0 1 1 1 0 Period protein 2/3C-terminal region DUF2360 PF10152.4 CCF33049.1 - 3.8 7.7 9.3 1.3 9.2 3.2 2.3 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) AAA_17 PF13207.1 CCF33050.1 - 2.4e-06 28.3 0.0 5.2e-06 27.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain PRK PF00485.13 CCF33050.1 - 6.9e-06 25.7 0.0 1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.1 CCF33050.1 - 1.1e-05 25.4 0.1 1.6e-05 24.9 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.24 CCF33050.1 - 1.8e-05 24.9 0.0 3.2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 CCF33050.1 - 2.8e-05 23.7 0.4 8.1e-05 22.2 0.3 1.8 1 0 0 1 1 1 1 Part of AAA domain Zeta_toxin PF06414.7 CCF33050.1 - 6.1e-05 22.2 0.1 0.00041 19.5 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin AAA_18 PF13238.1 CCF33050.1 - 0.00016 22.0 0.1 0.00044 20.5 0.0 1.8 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 CCF33050.1 - 0.00019 21.1 0.0 0.00052 19.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 CCF33050.1 - 0.00028 21.0 0.0 0.0007 19.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain NACHT PF05729.7 CCF33050.1 - 0.00053 19.6 0.0 0.0013 18.4 0.0 1.7 2 0 0 2 2 2 1 NACHT domain AAA_28 PF13521.1 CCF33050.1 - 0.0012 18.7 0.1 0.0049 16.8 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 CCF33050.1 - 0.0019 18.0 0.2 0.0086 15.9 0.0 2.1 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 CCF33050.1 - 0.0044 17.1 0.0 0.0078 16.3 0.0 1.4 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.1 CCF33050.1 - 0.0077 15.6 0.0 0.013 14.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.1 CCF33050.1 - 0.012 15.2 0.0 0.023 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 CCF33050.1 - 0.014 14.2 0.0 0.023 13.5 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain ABC_tran PF00005.22 CCF33050.1 - 0.017 15.3 0.0 0.036 14.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter NTPase_1 PF03266.10 CCF33050.1 - 0.019 14.7 0.0 0.042 13.5 0.0 1.6 1 0 0 1 1 1 0 NTPase RuvB_N PF05496.7 CCF33050.1 - 0.021 13.9 0.0 0.037 13.0 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 CCF33050.1 - 0.03 14.2 0.0 0.05 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.10 CCF33050.1 - 0.034 12.8 0.0 0.056 12.1 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Arch_ATPase PF01637.13 CCF33050.1 - 0.049 13.3 0.0 0.077 12.6 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase Mg_chelatase PF01078.16 CCF33050.1 - 0.05 12.7 0.0 0.085 11.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.1 CCF33050.1 - 0.11 12.5 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain UPF0079 PF02367.12 CCF33050.1 - 0.11 12.1 0.0 0.34 10.5 0.0 1.7 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 SRP54 PF00448.17 CCF33050.1 - 0.11 11.9 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_11 PF13086.1 CCF33050.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.4 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.13 CCF33050.1 - 0.14 11.6 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Glyco_hydro_3 PF00933.16 CCF33051.1 - 1.7e-53 181.5 0.0 2.1e-53 181.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 CCF33051.1 - 7.3e-10 38.7 0.1 2.1e-07 30.7 0.0 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 3 C-terminal domain adh_short PF00106.20 CCF33052.1 - 2.1e-07 31.0 1.7 2.4e-07 30.7 1.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF33052.1 - 7.7e-05 22.5 0.2 8.9e-05 22.3 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF33052.1 - 0.0017 18.0 0.7 0.002 17.8 0.5 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF33052.1 - 0.051 13.5 0.8 0.065 13.2 0.5 1.1 1 0 0 1 1 1 0 NADH(P)-binding ADH_N PF08240.7 CCF33053.1 - 1.3e-30 105.3 3.2 1.4e-30 105.2 2.2 1.0 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Myosin_head PF00063.16 CCF33055.1 - 3.8e-249 828.3 0.0 3.8e-249 828.3 0.0 2.6 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_tail_1 PF01576.14 CCF33055.1 - 1.1e-26 92.8 124.2 1.1e-26 92.8 86.1 5.9 3 2 1 4 4 4 2 Myosin tail Myosin_N PF02736.14 CCF33055.1 - 0.0004 20.0 2.0 0.00041 19.9 0.2 1.9 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain Filament PF00038.16 CCF33055.1 - 0.0015 18.0 18.0 0.0015 18.0 12.5 10.2 1 1 6 9 9 9 4 Intermediate filament protein AAA_19 PF13245.1 CCF33055.1 - 0.076 12.7 0.0 0.28 10.9 0.0 2.0 1 0 0 1 1 1 0 Part of AAA domain zf-C3H1 PF10650.4 CCF33056.1 - 0.21 11.1 0.5 0.34 10.4 0.4 1.3 1 0 0 1 1 1 0 Putative zinc-finger domain Spc7 PF08317.6 CCF33056.1 - 0.23 10.1 9.6 0.5 8.9 6.7 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein V_ATPase_I PF01496.14 CCF33056.1 - 1.2 6.8 4.1 2.1 6.0 2.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RTA1 PF04479.8 CCF33057.1 - 7.9e-47 159.6 1.4 1.2e-46 158.9 1.0 1.2 1 0 0 1 1 1 1 RTA1 like protein Poxvirus_B22R_C PF13168.1 CCF33057.1 - 0.025 13.8 0.1 0.047 12.9 0.0 1.4 1 0 0 1 1 1 0 Poxvirus B22R protein C-terminal Tox-SGS PF15651.1 CCF33057.1 - 0.16 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Salivary glad secreted protein domain toxin CAP PF00188.21 CCF33058.1 - 7.6e-21 74.8 2.1 9.8e-21 74.5 1.5 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family MoaE PF02391.12 CCF33059.1 - 3e-30 104.4 0.0 3.6e-30 104.1 0.0 1.1 1 0 0 1 1 1 1 MoaE protein G-patch PF01585.18 CCF33060.1 - 1e-11 44.4 2.8 2e-11 43.4 1.9 1.5 1 0 0 1 1 1 1 G-patch domain RRM_6 PF14259.1 CCF33060.1 - 7.5e-10 38.6 0.0 0.00066 19.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CCF33060.1 - 6.3e-07 28.9 0.0 0.021 14.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G-patch_2 PF12656.2 CCF33060.1 - 1.2e-05 25.0 1.2 1.2e-05 25.0 0.9 2.1 2 0 0 2 2 2 1 DExH-box splicing factor binding site zf-RanBP PF00641.13 CCF33060.1 - 6.4e-05 21.9 5.1 0.00014 20.9 3.6 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RED_N PF07808.8 CCF33060.1 - 0.0008 18.6 2.7 0.0018 17.5 1.9 1.5 1 0 0 1 1 1 1 RED-like protein N-terminal region RRM_5 PF13893.1 CCF33060.1 - 0.0032 17.2 0.1 4.2 7.2 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_2 PF12756.2 CCF33060.1 - 0.038 14.0 1.4 0.057 13.5 0.4 1.7 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 CCF33060.1 - 2.7 8.2 5.3 0.64 10.2 1.0 1.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Choline_kinase PF01633.15 CCF33061.1 - 1.2e-55 188.4 0.7 1.5e-54 184.7 0.0 2.2 2 0 0 2 2 2 1 Choline/ethanolamine kinase Choline_kin_N PF04428.9 CCF33061.1 - 1.7e-21 75.4 0.0 3.3e-21 74.5 0.0 1.5 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.18 CCF33061.1 - 2.3e-05 24.2 0.1 2.3e-05 24.2 0.1 2.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family RTTN_N PF14726.1 CCF33061.1 - 0.09 13.3 0.0 0.3 11.6 0.0 1.9 2 0 0 2 2 2 0 Rotatin, an armadillo repeat protein, centriole functioning Methyltransf_23 PF13489.1 CCF33062.1 - 8.1e-21 74.4 0.1 1.2e-20 73.8 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF33062.1 - 2.3e-10 41.0 0.4 6.1e-09 36.4 0.2 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF33062.1 - 9e-09 35.7 0.0 6.1e-08 33.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF33062.1 - 2.4e-07 30.4 0.0 4.3e-06 26.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF33062.1 - 6.8e-07 29.6 0.0 1.4e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF33062.1 - 2.8e-06 27.5 0.1 1.2e-05 25.6 0.0 2.1 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 CCF33062.1 - 0.00088 18.7 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.8 CCF33062.1 - 0.0015 17.6 0.0 0.0023 17.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 CCF33062.1 - 0.0027 17.1 0.0 0.018 14.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.12 CCF33062.1 - 0.01 14.9 0.0 0.017 14.1 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_26 PF13659.1 CCF33062.1 - 0.016 15.2 0.1 0.12 12.3 0.1 2.2 1 1 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.14 CCF33062.1 - 0.026 14.5 0.1 0.053 13.4 0.0 1.5 2 0 0 2 2 2 0 FtsJ-like methyltransferase CMAS PF02353.15 CCF33062.1 - 0.034 13.2 0.0 0.048 12.7 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 CCF33062.1 - 0.036 13.1 0.0 0.27 10.3 0.0 2.1 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF938 PF06080.7 CCF33062.1 - 0.071 12.6 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) PCMT PF01135.14 CCF33062.1 - 0.17 11.3 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FAD_binding_3 PF01494.14 CCF33063.1 - 1.5e-23 83.4 0.0 1.1e-22 80.6 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.19 CCF33063.1 - 5e-05 22.5 0.8 0.079 12.0 0.0 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 CCF33063.1 - 0.0034 17.3 0.4 0.015 15.3 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF33063.1 - 0.0092 14.9 1.1 0.42 9.4 0.0 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 CCF33063.1 - 0.11 12.9 3.9 0.28 11.6 0.1 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Mito_carr PF00153.22 CCF33065.1 - 4.3e-71 234.7 1.5 6.8e-26 89.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.14 CCF33065.1 - 0.61 10.1 3.8 0.31 11.1 0.1 2.6 3 1 0 3 3 3 0 Tim17/Tim22/Tim23/Pmp24 family RCC1 PF00415.13 CCF33066.1 - 8.8e-22 77.0 2.2 3.3e-06 27.2 0.0 5.4 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.26 CCF33066.1 - 2.3e-13 50.0 0.0 6.2e-08 32.6 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain Ank_4 PF13637.1 CCF33066.1 - 1.7e-09 37.9 1.0 3.2e-08 33.8 0.1 3.1 2 1 1 3 3 3 1 Ankyrin repeats (many copies) RCC1_2 PF13540.1 CCF33066.1 - 4.5e-07 29.3 1.4 4.5e-07 29.3 0.9 3.3 4 0 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat Ank_3 PF13606.1 CCF33066.1 - 7.2e-06 25.7 0.2 0.012 15.8 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 CCF33066.1 - 0.0002 21.6 0.1 0.00087 19.5 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 CCF33066.1 - 0.012 15.3 0.0 0.04 13.7 0.0 1.9 1 0 0 1 1 1 0 Ankyrin repeat Ank_5 PF13857.1 CCF33066.1 - 0.017 15.3 0.2 0.64 10.3 0.1 3.4 3 1 1 4 4 4 0 Ankyrin repeats (many copies) Metallothio_6 PF05522.6 CCF33069.1 - 0.18 12.1 20.4 4.1 7.7 6.6 2.2 1 1 1 2 2 2 0 Metallothionein MSG PF02349.10 CCF33069.1 - 0.5 10.3 9.5 2 8.4 1.1 2.1 1 1 1 2 2 2 0 Major surface glycoprotein Ribosomal_L31 PF01197.13 CCF33070.1 - 0.00015 21.7 0.0 0.00028 20.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L31 Flavin_Reduct PF01613.13 CCF33071.1 - 1.8e-33 115.5 0.0 2.4e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 Flavin reductase like domain HSP90 PF00183.13 CCF33072.1 - 2.3e-256 851.3 37.9 2.7e-256 851.0 26.3 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.21 CCF33072.1 - 1.3e-11 44.1 0.0 2.4e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 CCF33072.1 - 9.6e-11 41.4 0.2 9.6e-11 41.4 0.1 2.4 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.4 CCF33072.1 - 0.018 14.8 0.3 0.067 12.9 0.2 2.0 1 0 0 1 1 1 0 Tumour suppressor protein Claudin_2 PF13903.1 CCF33073.1 - 0.98 9.0 16.4 0.52 9.9 7.1 2.1 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction VHS PF00790.14 CCF33074.1 - 0.00095 18.8 0.0 0.0027 17.3 0.0 1.7 2 0 0 2 2 2 1 VHS domain CTD_bind PF04818.8 CCF33074.1 - 0.002 18.3 0.0 0.0051 17.0 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase II-binding domain. zf-C2H2_4 PF13894.1 CCF33074.1 - 0.013 15.7 2.3 6.4 7.3 0.3 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger CFIA_Pcf11 PF11526.3 CCF33074.1 - 0.096 12.8 2.8 1.3 9.2 2.0 2.3 1 1 0 1 1 1 0 Subunit of cleavage factor IA Pcf11 zf-C2HC_2 PF13913.1 CCF33074.1 - 0.1 12.3 4.1 1.6 8.4 0.5 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type RRN7 PF11781.3 CCF33074.1 - 0.36 10.3 2.7 0.62 9.6 0.4 2.1 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-C2H2 PF00096.21 CCF33074.1 - 5.1 7.6 6.9 14 6.2 0.3 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type ABC_tran PF00005.22 CCF33075.1 - 9.7e-34 116.6 0.0 2e-33 115.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 CCF33075.1 - 4.2e-16 59.1 1.1 5.9e-16 58.6 0.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 CCF33075.1 - 2.6e-05 23.5 0.0 0.0012 18.1 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 CCF33075.1 - 0.00027 20.9 0.0 0.00053 20.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.1 CCF33075.1 - 0.0013 18.7 0.2 0.36 10.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CCF33075.1 - 0.0014 18.8 0.2 0.0091 16.1 0.1 2.1 1 1 0 1 1 1 1 AAA domain ABC_ATPase PF09818.4 CCF33075.1 - 0.0016 17.0 0.2 0.0025 16.4 0.1 1.3 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA PF00004.24 CCF33075.1 - 0.0025 17.9 0.2 0.041 14.0 0.2 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CCF33075.1 - 0.0051 17.6 0.0 0.011 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 CCF33075.1 - 0.011 15.4 0.1 0.056 13.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SbcCD_C PF13558.1 CCF33075.1 - 0.025 14.5 1.3 0.23 11.4 0.9 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 CCF33075.1 - 0.026 14.0 0.0 0.064 12.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.1 CCF33075.1 - 0.029 13.9 0.1 0.22 11.0 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 CCF33075.1 - 0.074 12.4 0.5 0.2 11.0 0.2 1.7 2 0 0 2 2 2 0 AAA-like domain Sigma54_activ_2 PF14532.1 CCF33075.1 - 0.09 12.8 0.0 0.61 10.1 0.0 2.3 2 1 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.12 CCF33075.1 - 0.097 12.0 1.0 0.86 8.9 0.0 2.5 2 1 1 3 3 3 0 IstB-like ATP binding protein AAA_25 PF13481.1 CCF33075.1 - 0.13 11.6 0.0 3.3 7.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain Abhydrolase_6 PF12697.2 CCF33076.1 - 1.6e-22 80.5 0.3 2e-22 80.2 0.2 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CCF33076.1 - 9e-22 76.7 0.0 2.1e-21 75.5 0.0 1.7 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_5 PF12695.2 CCF33076.1 - 4.5e-14 52.4 0.0 6.7e-14 51.8 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase PF07224.6 CCF33076.1 - 0.00087 18.1 0.0 0.0012 17.6 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase Abhydrolase_1 PF00561.15 CCF33076.1 - 0.00096 18.7 0.0 0.0012 18.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF33076.1 - 0.0019 17.4 0.1 0.019 14.1 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Esterase PF00756.15 CCF33076.1 - 0.018 14.4 0.0 0.027 13.9 0.0 1.4 1 1 0 1 1 1 0 Putative esterase Chlorophyllase2 PF12740.2 CCF33076.1 - 0.021 13.6 0.0 0.032 13.1 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Lipase_3 PF01764.20 CCF33076.1 - 0.044 13.3 0.0 0.067 12.7 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF1749 PF08538.5 CCF33076.1 - 0.053 12.4 0.0 0.098 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) PGAP1 PF07819.8 CCF33076.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_3 PF07859.8 CCF33076.1 - 0.13 11.8 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Cation_efflux PF01545.16 CCF33077.1 - 1.7e-13 50.3 13.6 1.9e-11 43.6 5.4 2.1 1 1 1 2 2 2 2 Cation efflux family EI24 PF07264.6 CCF33077.1 - 0.24 10.7 8.2 0.026 13.9 2.1 1.8 1 1 1 2 2 2 0 Etoposide-induced protein 2.4 (EI24) ER_lumen_recept PF00810.13 CCF33077.1 - 0.89 10.0 8.2 0.047 14.1 1.5 2.0 2 1 0 2 2 2 0 ER lumen protein retaining receptor HATPase_c_3 PF13589.1 CCF33079.1 - 3e-16 59.3 0.4 6.8e-16 58.1 0.3 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 CCF33079.1 - 4.6e-11 42.4 0.1 1.3e-10 41.0 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_mis_repair PF01119.14 CCF33079.1 - 1.6e-06 27.5 0.0 4.6e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain DMRL_synthase PF00885.14 CCF33080.1 - 7.4e-46 155.3 0.1 6.3e-27 94.0 0.0 2.0 2 0 0 2 2 2 2 6,7-dimethyl-8-ribityllumazine synthase Oxidored_FMN PF00724.15 CCF33082.1 - 2.1e-91 306.4 0.0 2.5e-91 306.2 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family 7tm_2 PF00002.19 CCF33084.1 - 1.5e-13 50.3 4.5 2.9e-13 49.4 3.1 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.6 CCF33084.1 - 2.8e-11 42.9 5.0 2.8e-11 42.9 3.5 2.0 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor 7tm_1 PF00001.16 CCF33084.1 - 2.8e-07 29.9 3.4 4.2e-07 29.3 2.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.3 CCF33084.1 - 3.1e-07 30.1 8.0 6.4e-07 29.1 5.6 1.5 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7TM_GPCR_Srsx PF10320.4 CCF33084.1 - 0.00038 19.7 2.8 0.00038 19.7 2.0 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx Frizzled PF01534.12 CCF33084.1 - 1.3 7.6 9.6 19 3.9 6.6 2.3 1 1 0 1 1 1 0 Frizzled/Smoothened family membrane region CoA_transf_3 PF02515.12 CCF33087.1 - 4.1e-52 176.2 0.2 5.4e-52 175.8 0.1 1.2 1 0 0 1 1 1 1 CoA-transferase family III Nudix_N PF12535.3 CCF33087.1 - 0.024 14.0 0.0 0.058 12.8 0.0 1.6 1 0 0 1 1 1 0 Hydrolase of X-linked nucleoside diphosphate N terminal adh_short PF00106.20 CCF33088.1 - 1.4e-17 64.1 1.2 2.2e-17 63.4 0.8 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF33088.1 - 1.2e-07 31.6 0.5 1.9e-07 30.9 0.4 1.4 1 1 0 1 1 1 1 KR domain Dynamin_M PF01031.15 CCF33089.1 - 2.5e-106 354.7 0.1 7.1e-106 353.3 0.0 1.7 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.18 CCF33089.1 - 2.6e-56 190.0 0.0 4.8e-56 189.1 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.13 CCF33089.1 - 3.8e-29 100.4 4.3 3.8e-29 100.4 3.0 2.0 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 CCF33089.1 - 0.00019 21.3 0.9 0.0022 17.9 0.2 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 CCF33089.1 - 0.0078 16.7 0.0 0.037 14.5 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein RPE65 PF03055.10 CCF33090.1 - 3.9e-135 451.1 0.0 4.4e-135 450.9 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Sugar_tr PF00083.19 CCF33091.1 - 4.1e-121 404.6 22.2 5e-121 404.4 15.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF33091.1 - 6.2e-23 81.0 37.1 1.4e-18 66.8 9.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily GFA PF04828.9 CCF33092.1 - 0.018 14.9 0.1 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme Cupin_2 PF07883.6 CCF33093.1 - 1.9e-15 56.1 0.2 3.5e-15 55.2 0.0 1.6 2 0 0 2 2 2 1 Cupin domain Cupin_1 PF00190.17 CCF33093.1 - 9.8e-05 21.8 0.0 0.00014 21.2 0.0 1.3 1 0 0 1 1 1 1 Cupin ARD PF03079.9 CCF33093.1 - 0.0011 18.9 0.3 0.0029 17.5 0.0 1.8 2 0 0 2 2 2 1 ARD/ARD' family Cupin_6 PF12852.2 CCF33093.1 - 0.0029 17.2 0.0 0.0041 16.7 0.0 1.2 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.14 CCF33093.1 - 0.0029 17.2 0.0 0.0047 16.6 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_3 PF05899.7 CCF33093.1 - 0.0096 15.2 0.1 0.019 14.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) JmjC PF02373.17 CCF33093.1 - 0.018 15.3 0.0 0.032 14.4 0.0 1.4 1 0 0 1 1 1 0 JmjC domain, hydroxylase GPI PF06560.6 CCF33093.1 - 0.063 12.3 0.0 0.096 11.7 0.0 1.3 1 0 0 1 1 1 0 Glucose-6-phosphate isomerase (GPI) CReP_N PF10472.4 CCF33093.1 - 0.11 11.2 0.1 0.15 10.7 0.0 1.1 1 0 0 1 1 1 0 eIF2-alpha phosphatase phosphorylation constitutive repressor ADH_N PF08240.7 CCF33097.1 - 4.7e-14 52.0 0.1 5.7e-14 51.8 0.1 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_assoc PF13823.1 CCF33097.1 - 0.00086 18.9 0.0 0.0024 17.4 0.0 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-associated Myosin_head PF00063.16 CCF33098.1 - 3.2e-173 577.4 0.0 4.2e-173 577.0 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.23 CCF33098.1 - 3.7e-17 61.8 0.0 5.9e-12 45.2 0.0 2.8 1 1 1 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain MMR_HSR1 PF01926.18 CCF33098.1 - 0.002 18.0 0.1 0.72 9.8 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.1 CCF33098.1 - 0.0046 16.9 4.4 0.019 14.9 0.0 3.0 3 0 0 3 3 3 1 AAA ATPase domain AAA_29 PF13555.1 CCF33098.1 - 0.0047 16.4 0.1 0.013 14.9 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 CCF33098.1 - 0.0083 15.5 0.2 0.087 12.2 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.1 CCF33098.1 - 0.013 15.8 0.6 0.21 11.8 0.1 2.4 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 CCF33098.1 - 0.017 14.3 0.0 0.11 11.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 ABC_tran PF00005.22 CCF33098.1 - 0.018 15.3 1.3 0.075 13.3 0.0 2.4 2 0 0 2 2 2 0 ABC transporter VirD1 PF07328.6 CCF33098.1 - 0.049 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 T-DNA border endonuclease VirD1 AAA_22 PF13401.1 CCF33098.1 - 0.093 12.8 1.8 0.19 11.8 0.0 2.4 3 0 0 3 3 3 0 AAA domain WD40 PF00400.27 CCF33101.1 - 9.4e-44 145.7 10.6 2.4e-08 33.5 0.0 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.2 CCF33101.1 - 2.8e-08 33.3 0.0 6.4e-08 32.2 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF33101.1 - 6.7e-07 28.8 0.0 1.5e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.3 CCF33101.1 - 2.1e-06 26.2 1.6 0.15 10.2 0.0 3.7 1 1 2 4 4 4 3 Nucleoporin Nup120/160 PQQ_2 PF13360.1 CCF33101.1 - 0.00026 20.5 0.1 0.0005 19.5 0.0 1.4 1 0 0 1 1 1 1 PQQ-like domain Cytochrom_D1 PF02239.11 CCF33101.1 - 0.0016 16.8 0.0 0.0028 16.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome D1 heme domain FlaG PF03646.10 CCF33101.1 - 0.24 11.5 0.0 4.3 7.5 0.0 2.9 3 0 0 3 3 3 0 FlaG protein eIF-3_zeta PF05091.7 CCF33102.1 - 1.4e-191 637.6 0.0 1.7e-191 637.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF569 PF04601.8 CCF33102.1 - 0.035 13.5 0.1 0.074 12.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF569) bZIP_1 PF00170.16 CCF33103.1 - 0.00075 19.4 7.2 0.00075 19.4 5.0 1.7 2 0 0 2 2 2 1 bZIP transcription factor PAP1 PF08601.5 CCF33103.1 - 0.0014 18.4 0.7 0.9 9.1 0.0 2.4 2 0 0 2 2 2 2 Transcription factor PAP1 TSC22 PF01166.13 CCF33103.1 - 0.12 12.3 1.4 0.28 11.1 0.5 1.9 2 0 0 2 2 2 0 TSC-22/dip/bun family bZIP_2 PF07716.10 CCF33103.1 - 2.8 7.8 10.1 11 5.8 7.0 2.0 1 1 0 1 1 1 0 Basic region leucine zipper DUF904 PF06005.7 CCF33103.1 - 3.9 7.8 7.7 0.5 10.6 1.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF904) Zn_clus PF00172.13 CCF33104.1 - 3.1e-10 39.8 7.4 6e-10 38.8 5.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short_C2 PF13561.1 CCF33106.1 - 2.6e-26 92.8 0.2 3e-26 92.6 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF33106.1 - 7.9e-13 48.6 0.8 1.2e-12 48.1 0.5 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF33106.1 - 5.7e-09 35.8 0.2 1.1e-08 34.9 0.1 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF33106.1 - 0.00062 19.8 1.5 0.0019 18.2 1.0 2.0 1 1 0 1 1 1 1 NADH(P)-binding 2-Hacid_dh_C PF02826.14 CCF33106.1 - 0.009 15.1 0.0 0.016 14.3 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N PF00107.21 CCF33106.1 - 0.015 14.8 0.8 0.11 12.0 0.4 2.5 2 1 0 2 2 2 0 Zinc-binding dehydrogenase CTP_transf_3 PF02348.14 CCF33106.1 - 0.025 14.2 0.0 0.037 13.6 0.0 1.2 1 0 0 1 1 1 0 Cytidylyltransferase Shikimate_DH PF01488.15 CCF33106.1 - 0.049 13.7 0.0 0.091 12.8 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 CCF33106.1 - 0.11 12.2 0.3 0.2 11.3 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Aldo_ket_red PF00248.16 CCF33109.1 - 2.8e-55 187.1 0.0 3.2e-55 186.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Methyltransf_25 PF13649.1 CCF33111.1 - 1.4e-08 35.0 0.1 2.1e-08 34.4 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF33111.1 - 0.00025 21.4 0.1 0.00042 20.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ribosomal_S26e PF01283.14 CCF33112.1 - 4.8e-51 171.8 9.0 5.5e-51 171.6 6.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e Fer4_7 PF12838.2 CCF33112.1 - 0.044 14.1 1.1 1.2 9.6 0.4 2.2 2 0 0 2 2 2 0 4Fe-4S dicluster domain Zn_ribbon_2 PF12674.2 CCF33112.1 - 0.048 13.9 0.2 8 6.8 0.0 2.2 1 1 1 2 2 2 0 Putative zinc ribbon domain DUF1918 PF08940.6 CCF33112.1 - 0.067 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) DUF3129 PF11327.3 CCF33113.1 - 1.9e-57 194.0 11.0 2.2e-57 193.8 7.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3129) Acetyltransf_1 PF00583.19 CCF33114.1 - 8.8e-16 57.7 0.0 1.3e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 CCF33114.1 - 8.6e-11 41.9 0.0 1.1e-10 41.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 CCF33114.1 - 2.3e-09 37.2 0.0 3.2e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 CCF33114.1 - 2.1e-08 34.4 0.0 2.6e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 CCF33114.1 - 4.7e-07 29.8 0.0 6.3e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 CCF33114.1 - 7e-07 29.0 0.0 1.1e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.5 CCF33114.1 - 8.7e-06 25.4 0.0 4.3e-05 23.1 0.0 2.0 3 0 0 3 3 3 1 FR47-like protein Acetyltransf_9 PF13527.1 CCF33114.1 - 9.6e-06 25.4 0.0 1.3e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 CCF33114.1 - 4.6e-05 23.3 0.1 6.2e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltr_2 PF13718.1 CCF33114.1 - 0.019 14.2 0.1 0.3 10.3 0.1 2.1 1 1 0 1 1 1 0 GNAT acetyltransferase 2 DUF1999 PF09390.5 CCF33114.1 - 0.073 12.4 0.0 0.16 11.3 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1999) Acetyltransf_5 PF13444.1 CCF33114.1 - 0.097 13.2 0.0 0.19 12.3 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain ADH_N PF08240.7 CCF33116.1 - 2.6e-08 33.5 0.0 5e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF33116.1 - 9.3e-08 31.6 0.0 2.5e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Epimerase PF01370.16 CCF33116.1 - 0.0012 18.3 0.0 0.0016 17.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF33116.1 - 0.09 12.7 0.1 0.13 12.2 0.1 1.2 1 0 0 1 1 1 0 NADH(P)-binding DUF320 PF03777.8 CCF33116.1 - 0.096 12.4 0.1 0.22 11.2 0.1 1.6 1 0 0 1 1 1 0 Small secreted domain (DUF320) BsuPI PF12690.2 CCF33116.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Intracellular proteinase inhibitor Methyltransf_24 PF13578.1 CCF33117.1 - 1.4e-12 48.3 0.1 3.1e-12 47.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_3 PF01596.12 CCF33117.1 - 3.5e-09 36.0 0.1 7.7e-09 34.8 0.0 1.5 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_18 PF12847.2 CCF33117.1 - 0.0014 19.2 0.1 0.0033 17.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain HhH-GPD PF00730.20 CCF33119.1 - 6.6e-09 36.0 0.0 1.5e-08 34.9 0.0 1.7 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 CCF33119.1 - 0.037 13.7 0.0 0.12 12.1 0.0 2.0 1 0 0 1 1 1 0 Helix-hairpin-helix motif Sugar_tr PF00083.19 CCF33120.1 - 6.2e-58 196.4 16.7 7.5e-58 196.1 11.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF33120.1 - 1.7e-20 73.0 29.8 4.1e-18 65.2 9.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CCF33120.1 - 0.0001 20.8 23.1 0.0014 17.1 5.3 3.5 2 2 1 3 3 3 3 MFS/sugar transport protein MFS_1_like PF12832.2 CCF33120.1 - 0.035 13.8 2.9 4.8 7.0 0.4 3.4 3 0 0 3 3 3 0 MFS_1 like family GDE_N_bis PF14742.1 CCF33121.1 - 0.03 13.7 0.1 0.039 13.3 0.1 1.2 1 0 0 1 1 1 0 N-terminal domain of (some) glycogen debranching enzymes Pkinase PF00069.20 CCF33122.1 - 6.2e-20 71.4 0.0 1.9e-19 69.8 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF33122.1 - 4.4e-07 29.2 0.0 0.00074 18.6 0.0 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 CCF33122.1 - 0.0018 17.2 0.1 0.077 11.9 0.0 2.4 3 0 0 3 3 3 2 Kinase-like Epimerase PF01370.16 CCF33124.1 - 1.1e-12 47.9 0.0 1.3e-12 47.6 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF33124.1 - 1.2e-12 47.1 0.0 1.4e-12 46.8 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 CCF33124.1 - 2.5e-10 40.6 0.3 4.4e-10 39.8 0.2 1.4 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 CCF33124.1 - 2.5e-07 29.8 0.1 2.1e-06 26.8 0.1 1.9 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 CCF33124.1 - 4.4e-06 26.7 0.5 1.5e-05 25.0 0.4 1.7 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.8 CCF33124.1 - 8.1e-06 25.2 0.2 1.2e-05 24.7 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.10 CCF33124.1 - 0.0025 16.7 0.0 0.0034 16.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.5 CCF33124.1 - 0.0029 17.2 0.8 0.016 14.9 0.6 1.9 1 1 0 1 1 1 1 KR domain Ank_2 PF12796.2 CCF33125.1 - 5.5e-17 61.8 0.0 7.5e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 CCF33125.1 - 1.4e-16 59.3 0.1 1.5e-11 43.5 0.2 2.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 CCF33125.1 - 2.4e-15 56.5 0.2 2.1e-07 31.2 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF33125.1 - 5.1e-12 45.6 0.3 2.3e-11 43.5 0.1 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF33125.1 - 1.4e-11 43.4 0.0 1.8e-08 33.7 0.0 2.9 3 1 0 3 3 3 2 Ankyrin repeat p450 PF00067.17 CCF33128.1 - 1.1e-57 195.5 0.3 1.5e-57 195.1 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 NmrA PF05368.8 CCF33129.1 - 6.9e-21 74.5 0.1 9.6e-21 74.1 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF33129.1 - 1.1e-10 41.8 0.0 1.4e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 CCF33129.1 - 8.5e-05 21.6 0.0 0.00011 21.3 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Epimerase PF01370.16 CCF33129.1 - 0.00044 19.7 0.0 0.0012 18.3 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 CCF33129.1 - 0.00055 18.9 0.0 0.00082 18.3 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein DapB_N PF01113.15 CCF33129.1 - 0.0038 17.1 0.0 0.0079 16.1 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus 3Beta_HSD PF01073.14 CCF33129.1 - 0.0056 15.4 0.0 0.027 13.1 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.19 CCF33129.1 - 0.006 16.8 0.1 0.013 15.8 0.1 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain FliG_C PF01706.11 CCF33129.1 - 0.054 13.4 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 FliG C-terminal domain KR PF08659.5 CCF33129.1 - 0.078 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 KR domain Ank_2 PF12796.2 CCF33130.1 - 6.2e-70 231.5 0.7 5.5e-15 55.4 0.0 6.6 2 2 5 7 7 7 6 Ankyrin repeats (3 copies) Ank PF00023.25 CCF33130.1 - 8.1e-47 154.7 8.8 9.6e-06 25.1 0.0 12.2 12 0 0 12 12 12 9 Ankyrin repeat Ank_3 PF13606.1 CCF33130.1 - 5.2e-45 146.9 0.0 5.2e-06 26.1 0.0 11.7 12 0 0 12 12 12 8 Ankyrin repeat Ank_4 PF13637.1 CCF33130.1 - 2.9e-39 132.7 3.9 1.4e-07 31.8 0.0 9.0 4 2 6 10 10 10 7 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF33130.1 - 9e-34 114.7 3.7 8.2e-07 29.0 0.0 8.0 5 2 4 9 9 9 8 Ankyrin repeats (many copies) DUF1843 PF08898.5 CCF33130.1 - 0.088 12.8 0.1 3 7.9 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) AAA PF00004.24 CCF33131.1 - 1.4e-38 132.0 0.1 1.8e-37 128.4 0.0 2.8 2 1 2 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF33131.1 - 7.8e-08 32.5 3.1 0.0016 18.4 0.0 4.7 3 1 1 4 4 4 1 AAA ATPase domain AAA_22 PF13401.1 CCF33131.1 - 1.4e-06 28.4 0.6 0.014 15.4 0.0 3.8 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.7 CCF33131.1 - 1.1e-05 24.6 0.0 2.2e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 CCF33131.1 - 0.00011 22.9 0.1 0.00067 20.4 0.0 2.5 2 1 0 2 2 1 1 AAA domain IstB_IS21 PF01695.12 CCF33131.1 - 0.00084 18.7 0.0 0.0023 17.3 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 CCF33131.1 - 0.0012 18.7 0.0 0.0052 16.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 CCF33131.1 - 0.0017 18.2 0.2 0.013 15.3 0.1 2.6 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 CCF33131.1 - 0.0023 18.2 0.1 0.046 14.0 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.1 CCF33131.1 - 0.0024 17.5 0.1 0.0088 15.7 0.0 2.0 2 0 0 2 2 1 1 Part of AAA domain AAA_5 PF07728.9 CCF33131.1 - 0.0092 15.7 0.1 0.027 14.1 0.1 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Arch_ATPase PF01637.13 CCF33131.1 - 0.012 15.3 0.1 7.6 6.1 0.0 2.8 2 1 1 3 3 3 0 Archaeal ATPase RNA_helicase PF00910.17 CCF33131.1 - 0.017 15.2 0.0 0.071 13.2 0.0 2.1 1 0 0 1 1 1 0 RNA helicase MYCBPAP PF14646.1 CCF33131.1 - 0.029 13.0 0.0 0.049 12.3 0.0 1.3 1 0 0 1 1 1 0 MYCBP-associated protein family Mg_chelatase PF01078.16 CCF33131.1 - 0.034 13.3 0.0 0.073 12.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NACHT PF05729.7 CCF33131.1 - 0.038 13.6 0.4 2.1 7.9 0.0 2.7 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.1 CCF33131.1 - 0.045 13.1 1.4 0.5 9.7 0.1 3.0 2 1 1 3 3 3 0 AAA domain TIP49 PF06068.8 CCF33131.1 - 0.051 12.2 0.0 0.086 11.5 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus AAA_24 PF13479.1 CCF33131.1 - 0.052 13.1 1.3 0.2 11.2 0.3 2.2 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.1 CCF33131.1 - 0.078 13.0 0.0 0.26 11.3 0.0 1.8 2 0 0 2 2 1 0 Sigma-54 interaction domain DUF2075 PF09848.4 CCF33131.1 - 0.21 10.5 0.9 0.56 9.1 0.2 2.0 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) TFIIH_BTF_p62_N PF08567.6 CCF33132.1 - 6.2e-26 89.8 0.0 1.5e-25 88.6 0.0 1.7 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain BSD PF03909.12 CCF33132.1 - 2.9e-22 78.1 1.0 3.9e-12 45.7 0.0 2.7 2 0 0 2 2 2 2 BSD domain Med3 PF11593.3 CCF33133.1 - 2 7.6 13.3 2.6 7.2 9.2 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal FCH PF00611.18 CCF33134.1 - 1.3e-23 82.9 2.4 1.5e-23 82.7 0.0 2.4 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain C1_1 PF00130.17 CCF33134.1 - 8.4e-15 54.2 5.3 1.3e-14 53.6 3.7 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 PF00018.23 CCF33134.1 - 2.5e-05 23.5 0.0 4.7e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 CCF33134.1 - 6.8e-05 22.3 0.1 0.00015 21.2 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.6 CCF33134.1 - 0.008 16.3 0.1 0.015 15.5 0.1 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain Allexi_40kDa PF05549.6 CCF33134.1 - 0.014 14.7 3.7 0.02 14.1 0.2 2.6 2 1 0 2 2 2 0 Allexivirus 40kDa protein DUF4206 PF13901.1 CCF33134.1 - 1.1 8.7 6.6 0.18 11.3 1.6 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4206) DEAD PF00270.24 CCF33136.1 - 2.6e-33 114.8 0.0 2.5e-32 111.7 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF33136.1 - 2.3e-22 78.6 0.0 4.3e-22 77.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_19 PF13245.1 CCF33136.1 - 0.00036 20.2 0.2 0.073 12.8 0.0 2.8 2 1 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 CCF33136.1 - 0.0029 17.2 0.0 0.0068 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CCF33136.1 - 0.011 15.8 0.2 0.19 11.8 0.1 2.5 2 1 0 2 2 2 0 AAA domain Helicase_C_2 PF13307.1 CCF33136.1 - 0.04 13.8 0.0 0.078 12.9 0.0 1.5 1 0 0 1 1 1 0 Helicase C-terminal domain Aspzincin_M35 PF14521.1 CCF33137.1 - 0.02 15.4 4.9 0.14 12.7 0.1 2.3 1 1 0 2 2 2 0 Lysine-specific metallo-endopeptidase AMP-binding PF00501.23 CCF33138.1 - 3.4e-92 309.0 0.0 9.3e-92 307.5 0.0 1.7 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF33138.1 - 0.019 15.8 0.0 0.065 14.1 0.0 1.9 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Ank_2 PF12796.2 CCF33140.1 - 2.2e-45 152.9 2.4 1.4e-18 67.0 0.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.1 CCF33140.1 - 1.1e-37 127.2 5.4 1.9e-09 37.4 0.9 5.3 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.25 CCF33140.1 - 1.6e-34 115.9 1.0 1.1e-06 28.1 0.0 6.3 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.1 CCF33140.1 - 2.2e-32 110.8 12.5 1.2e-08 35.2 0.1 5.3 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF33140.1 - 2.6e-29 98.3 0.1 0.00019 21.3 0.0 6.4 7 0 0 7 7 7 6 Ankyrin repeat TMF_DNA_bd PF12329.3 CCF33141.1 - 9.6e-15 54.1 4.0 9.6e-15 54.1 2.8 6.1 5 2 3 8 8 8 2 TATA element modulatory factor 1 DNA binding Tropomyosin_1 PF12718.2 CCF33141.1 - 5.9e-05 22.9 9.2 5.9e-05 22.9 6.4 4.0 3 1 0 4 4 4 2 Tropomyosin like DUF2524 PF10732.4 CCF33141.1 - 0.0041 17.2 0.7 0.0041 17.2 0.5 4.1 3 2 0 3 3 3 1 Protein of unknown function (DUF2524) MtrB PF05440.7 CCF33141.1 - 0.044 13.8 0.6 8.7 6.4 0.0 3.2 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase subunit B Reo_sigmaC PF04582.7 CCF33141.1 - 0.44 9.6 12.0 3.6 6.6 0.1 3.2 1 1 1 3 3 3 0 Reovirus sigma C capsid protein DUF1202 PF06717.6 CCF33141.1 - 0.83 8.8 13.0 0.049 12.9 0.2 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1202) Alpha-2-MRAP_C PF06401.6 CCF33141.1 - 5.9 6.6 25.7 0.023 14.5 2.1 3.9 1 1 1 3 3 3 0 Alpha-2-macroglobulin RAP, C-terminal domain Ceramidase PF05875.7 CCF33142.1 - 8.8e-96 320.0 12.5 1e-95 319.8 8.6 1.0 1 0 0 1 1 1 1 Ceramidase Renin_r PF07850.9 CCF33142.1 - 0.13 12.6 1.2 3 8.2 0.0 2.6 2 0 0 2 2 2 0 Renin receptor-like protein CDC50 PF03381.10 CCF33143.1 - 4.1e-103 344.3 0.2 5.1e-103 344.0 0.1 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family ABC2_membrane_3 PF12698.2 CCF33143.1 - 0.011 14.7 0.0 0.028 13.4 0.0 1.6 1 1 0 1 1 1 0 ABC-2 family transporter protein SPT16 PF08644.6 CCF33144.1 - 2.6e-57 192.9 0.1 2.6e-57 192.9 0.1 2.5 3 0 0 3 3 3 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.1 CCF33144.1 - 6.4e-53 178.6 0.9 6.4e-53 178.6 0.7 2.1 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Rtt106 PF08512.7 CCF33144.1 - 1.6e-22 79.2 0.7 4.2e-22 77.9 0.1 2.2 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Peptidase_M24 PF00557.19 CCF33144.1 - 6.9e-22 78.0 0.0 1.1e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 LysM PF01476.15 CCF33146.1 - 5.3e-12 45.4 0.0 1.8e-07 30.9 0.0 2.4 2 0 0 2 2 2 2 LysM domain KR PF08659.5 CCF33148.1 - 6.4e-30 104.1 0.4 1.2e-29 103.3 0.0 1.6 2 0 0 2 2 2 1 KR domain adh_short PF00106.20 CCF33148.1 - 9.8e-19 67.8 0.1 2.3e-18 66.6 0.1 1.6 1 0 0 1 1 1 1 short chain dehydrogenase PP-binding PF00550.20 CCF33148.1 - 1.9e-07 31.2 0.0 9e-07 29.0 0.0 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site Prefoldin_3 PF13758.1 CCF33149.1 - 5.2e-32 109.5 2.7 5.2e-32 109.5 1.8 2.2 2 0 0 2 2 2 1 Prefoldin subunit DUF3835 PF12927.2 CCF33149.1 - 4.4e-13 49.9 0.2 4.4e-13 49.9 0.1 4.7 4 1 1 5 5 5 1 Domain of unknown function (DUF3835) Prefoldin_2 PF01920.15 CCF33149.1 - 0.00028 20.6 14.5 0.014 15.1 0.2 4.8 4 0 0 4 4 4 2 Prefoldin subunit Prefoldin PF02996.12 CCF33149.1 - 0.0047 16.5 2.0 0.31 10.7 0.1 2.6 2 0 0 2 2 2 1 Prefoldin subunit V_ATPase_I PF01496.14 CCF33149.1 - 0.071 10.9 1.6 0.14 10.0 1.1 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HR1 PF02185.11 CCF33149.1 - 0.4 10.4 3.8 0.5 10.1 0.2 2.7 2 0 0 2 2 2 0 Hr1 repeat T4SS PF07996.6 CCF33149.1 - 0.75 9.6 5.4 4 7.2 0.0 2.9 3 1 0 3 3 3 0 Type IV secretion system proteins THOC7 PF05615.8 CCF33149.1 - 8.7 6.6 11.1 9.4 6.5 0.2 3.3 3 1 0 3 3 3 0 Tho complex subunit 7 CS PF04969.11 CCF33150.1 - 1.3e-16 60.8 0.1 1.3e-16 60.8 0.1 1.7 2 0 0 2 2 2 1 CS domain MAT1 PF06391.8 CCF33151.1 - 4.5e-31 107.9 4.4 5.5e-31 107.7 3.0 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4 PF00097.20 CCF33151.1 - 0.0014 18.2 4.2 0.0035 16.9 3.0 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF33151.1 - 0.029 14.0 5.9 0.052 13.2 4.1 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CCF33151.1 - 0.039 13.9 6.8 0.1 12.6 4.8 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) MRP-S26 PF14943.1 CCF33151.1 - 0.11 12.0 12.6 0.18 11.3 8.8 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 zf-RING_2 PF13639.1 CCF33151.1 - 0.16 11.8 6.5 0.53 10.1 4.4 1.9 1 1 1 2 2 2 0 Ring finger domain zf-RING_5 PF14634.1 CCF33151.1 - 0.28 10.9 9.0 2.4 7.9 6.5 2.1 1 1 1 2 2 2 0 zinc-RING finger domain zf-UDP PF14569.1 CCF33151.1 - 1.1 9.0 4.5 3.5 7.4 3.2 1.7 1 1 0 1 1 1 0 Zinc-binding RING-finger zf-RING_4 PF14570.1 CCF33151.1 - 1.4 8.5 10.4 20 4.8 7.8 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain nsp8 PF08717.5 CCF33151.1 - 2.6 7.6 4.9 1.5 8.3 1.8 1.7 2 0 0 2 2 2 0 nsp8 replicase CAF-1_p150 PF11600.3 CCF33151.1 - 8.3 5.7 19.1 14 5.0 13.2 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal ANTH PF07651.11 CCF33152.1 - 1e-67 227.8 0.3 1.3e-67 227.4 0.2 1.2 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.15 CCF33152.1 - 1.6e-08 34.4 0.0 2.7e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 ENTH domain DUF1720 PF08226.6 CCF33152.1 - 0.00014 21.8 45.4 0.00014 21.8 31.4 5.6 1 1 4 5 5 5 2 Domain of unknown function (DUF1720) tRNA-synt_2 PF00152.15 CCF33153.1 - 4.3e-99 331.4 0.0 6e-99 330.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.20 CCF33153.1 - 0.00011 21.8 0.0 0.004 16.7 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Asn_synthase PF00733.16 CCF33154.1 - 1.1e-53 182.3 0.0 1.5e-53 181.9 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 CCF33154.1 - 1e-35 122.2 0.0 1.7e-35 121.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 CCF33154.1 - 1.1e-34 119.2 0.0 2.6e-34 118.0 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.3 CCF33154.1 - 0.00038 19.7 0.0 0.00066 18.9 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.12 CCF33154.1 - 0.048 12.5 0.0 0.068 12.0 0.0 1.2 1 0 0 1 1 1 0 NAD synthase tRNA_Me_trans PF03054.11 CCF33154.1 - 0.078 11.5 0.0 0.12 10.9 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase Sugar_tr PF00083.19 CCF33155.1 - 4e-90 302.5 26.8 4.8e-90 302.2 18.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF33155.1 - 3.5e-18 65.4 36.2 1.8e-14 53.2 6.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CPSF73-100_C PF11718.3 CCF33158.1 - 3.8e-71 238.8 0.0 3e-70 235.9 0.0 2.0 2 0 0 2 2 2 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.3 CCF33158.1 - 2e-31 108.5 0.0 3.6e-31 107.7 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.22 CCF33158.1 - 3.5e-14 52.8 0.6 7.5e-14 51.8 0.4 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CCF33158.1 - 1.1e-12 47.9 0.5 2e-12 47.0 0.3 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain RMMBL PF07521.7 CCF33158.1 - 5.1e-07 29.3 0.1 1.1e-06 28.4 0.1 1.6 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase Lactamase_B_3 PF13483.1 CCF33158.1 - 3.5e-06 26.8 0.1 9.7e-06 25.3 0.1 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain V_ATPase_I PF01496.14 CCF33159.1 - 2.6e-299 994.4 0.3 3e-299 994.2 0.2 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family ERM PF00769.14 CCF33159.1 - 0.03 13.8 1.9 0.068 12.6 0.0 2.0 2 0 0 2 2 2 0 Ezrin/radixin/moesin family DUF1515 PF07439.6 CCF33159.1 - 0.15 11.8 0.7 0.58 9.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) Laminin_II PF06009.7 CCF33159.1 - 0.16 11.7 3.8 6.7 6.4 0.1 2.3 2 0 0 2 2 2 0 Laminin Domain II CheZ PF04344.8 CCF33159.1 - 0.16 11.6 2.3 0.78 9.3 0.1 2.2 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ Mod_r PF07200.8 CCF33159.1 - 0.34 10.8 7.1 0.36 10.7 1.0 2.3 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Filament PF00038.16 CCF33159.1 - 1.2 8.4 10.3 0.96 8.8 0.7 2.4 2 1 0 2 2 2 0 Intermediate filament protein IncA PF04156.9 CCF33159.1 - 2.5 7.6 5.8 10 5.6 1.9 2.5 2 0 0 2 2 2 0 IncA protein GAS PF13851.1 CCF33159.1 - 4.7 6.3 8.1 2.2 7.4 1.3 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding HET PF06985.6 CCF33162.1 - 1.4e-36 125.7 0.4 2.3e-36 124.9 0.3 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) FAD_binding_3 PF01494.14 CCF33163.1 - 6.8e-16 58.2 1.4 5.7e-15 55.2 1.0 2.0 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF33163.1 - 2.2e-12 46.5 5.2 7.1e-06 25.1 0.0 2.4 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF33163.1 - 6.8e-08 32.4 0.3 2.3e-07 30.7 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CCF33163.1 - 4.9e-07 28.9 2.9 6.6e-07 28.5 1.8 1.5 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 CCF33163.1 - 7.4e-07 29.2 0.2 1.8e-06 27.9 0.1 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF33163.1 - 3.7e-06 25.6 0.8 3.3e-05 22.5 0.5 2.0 1 1 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.7 CCF33163.1 - 3.8e-06 26.0 0.8 0.021 13.7 0.0 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_oxidored PF12831.2 CCF33163.1 - 1.5e-05 24.2 0.2 1.9e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 CCF33163.1 - 3.7e-05 24.0 0.8 0.00074 19.8 0.5 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF33163.1 - 6.9e-05 21.6 0.3 0.00021 20.0 0.1 1.9 2 1 1 3 3 3 1 Tryptophan halogenase Thi4 PF01946.12 CCF33163.1 - 0.00021 20.4 0.3 0.00037 19.6 0.2 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.1 CCF33163.1 - 0.0014 18.7 0.0 0.0022 18.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CCF33163.1 - 0.007 15.2 1.4 0.011 14.6 1.0 1.4 1 1 0 1 1 1 1 Glucose inhibited division protein A Amino_oxidase PF01593.19 CCF33163.1 - 0.017 14.2 0.1 0.43 9.5 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase FMO-like PF00743.14 CCF33163.1 - 0.021 13.0 0.4 0.03 12.5 0.3 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like 3HCDH_N PF02737.13 CCF33163.1 - 0.088 12.4 0.4 0.15 11.7 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MFS_1 PF07690.11 CCF33164.1 - 2e-10 39.9 11.5 2e-10 39.9 7.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Ebola_NP PF05505.7 CCF33165.1 - 0.069 11.2 0.3 0.078 11.0 0.2 1.0 1 0 0 1 1 1 0 Ebola nucleoprotein Oxidored-like PF09791.4 CCF33166.1 - 2.7e-25 87.5 2.6 2.7e-25 87.5 1.8 2.1 2 0 0 2 2 2 1 Oxidoreductase-like protein, N-terminal Trypan_PARP PF05887.6 CCF33166.1 - 6.2 6.6 13.7 13 5.6 9.5 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Pyr_redox_2 PF07992.9 CCF33169.1 - 2e-25 89.8 0.4 2.2e-15 57.1 0.0 3.4 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF33169.1 - 6.5e-14 52.0 0.0 2.9e-12 46.8 0.1 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF33169.1 - 0.0045 17.0 0.1 0.36 10.8 0.0 3.0 2 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase SRI PF08236.6 CCF33169.1 - 0.039 13.9 0.2 0.32 10.9 0.1 2.3 2 0 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain NAD_binding_7 PF13241.1 CCF33169.1 - 0.097 12.9 0.2 19 5.5 0.0 2.8 2 1 0 2 2 2 0 Putative NAD(P)-binding WEMBL PF05701.6 CCF33170.1 - 0.04 12.3 43.9 11 4.3 30.6 3.1 1 1 0 1 1 1 0 Weak chloroplast movement under blue light Reo_sigmaC PF04582.7 CCF33170.1 - 0.4 9.8 4.0 0.31 10.1 0.3 2.1 2 0 0 2 2 2 0 Reovirus sigma C capsid protein TPR_MLP1_2 PF07926.7 CCF33170.1 - 0.49 10.1 49.2 0.43 10.3 6.0 3.3 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein COesterase PF00135.23 CCF33172.1 - 9.9e-90 301.7 0.0 1.5e-89 301.1 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF33172.1 - 1.5e-08 34.4 0.1 6.2e-08 32.4 0.0 2.0 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF33172.1 - 3.2e-05 23.2 1.2 6e-05 22.3 0.8 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CCF33172.1 - 0.0012 18.5 0.1 0.0024 17.6 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family ACC_epsilon PF13822.1 CCF33173.1 - 0.024 14.9 0.9 0.049 13.9 0.6 1.5 1 0 0 1 1 1 0 Acyl-CoA carboxylase epsilon subunit p450 PF00067.17 CCF33174.1 - 4.4e-50 170.5 0.0 6.1e-50 170.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Dynamin_N PF00350.18 CCF33175.1 - 3.8e-15 56.1 0.0 1.4e-14 54.2 0.0 2.0 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 CCF33175.1 - 5.2e-07 29.6 0.0 0.00036 20.4 0.0 3.5 2 1 0 3 3 3 1 50S ribosome-binding GTPase DUF258 PF03193.11 CCF33175.1 - 8.5e-07 28.2 0.0 1.2e-05 24.5 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 CCF33175.1 - 7.7e-06 26.0 0.5 4.7e-05 23.4 0.0 2.5 3 0 0 3 3 3 1 AAA ATPase domain ABC_tran PF00005.22 CCF33175.1 - 0.00025 21.3 0.0 0.00096 19.4 0.0 2.0 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.1 CCF33175.1 - 0.01 15.9 0.6 0.21 11.7 0.0 3.4 4 0 0 4 4 4 0 AAA domain AAA_10 PF12846.2 CCF33175.1 - 0.011 15.2 0.0 0.09 12.1 0.0 2.4 2 1 0 2 2 2 0 AAA-like domain Miro PF08477.8 CCF33175.1 - 0.013 15.9 0.3 0.1 13.0 0.0 2.8 3 1 0 3 3 3 0 Miro-like protein AIG1 PF04548.11 CCF33175.1 - 0.02 14.0 0.0 0.099 11.7 0.0 2.2 3 0 0 3 3 3 0 AIG1 family Septin PF00735.13 CCF33175.1 - 0.049 12.6 0.0 0.088 11.8 0.0 1.4 1 0 0 1 1 1 0 Septin AAA_29 PF13555.1 CCF33175.1 - 0.094 12.2 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ldr_toxin PF13940.1 CCF33175.1 - 0.86 9.4 2.2 0.77 9.5 0.3 1.8 2 0 0 2 2 2 0 Toxin Ldr, type I toxin-antitoxin system AAA_18 PF13238.1 CCF33177.1 - 6e-29 100.9 0.4 1e-28 100.1 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 CCF33177.1 - 2.9e-16 60.3 0.6 7.1e-16 59.1 0.2 1.7 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.1 CCF33177.1 - 4.6e-06 26.5 0.1 0.00037 20.3 0.1 2.3 1 1 0 1 1 1 1 AAA domain ADK PF00406.17 CCF33177.1 - 1.5e-05 24.8 0.0 0.0028 17.5 0.0 2.2 2 0 0 2 2 2 1 Adenylate kinase AAA_28 PF13521.1 CCF33177.1 - 1.7e-05 24.8 0.1 8.8e-05 22.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 CCF33177.1 - 2.7e-05 24.3 0.0 0.0012 19.0 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SKI PF01202.17 CCF33177.1 - 0.00017 21.5 0.2 0.002 18.0 0.2 2.0 1 1 0 1 1 1 1 Shikimate kinase NTPase_1 PF03266.10 CCF33177.1 - 0.00032 20.4 0.0 0.00061 19.5 0.0 1.6 1 0 0 1 1 1 1 NTPase Thymidylate_kin PF02223.12 CCF33177.1 - 0.0011 18.3 0.1 0.74 9.1 0.0 2.1 2 0 0 2 2 2 2 Thymidylate kinase AAA_16 PF13191.1 CCF33177.1 - 0.0012 18.8 0.0 0.0022 18.0 0.0 1.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 CCF33177.1 - 0.0014 18.7 0.0 0.0055 16.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.5 CCF33177.1 - 0.0019 17.4 0.0 0.0047 16.1 0.0 1.6 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_5 PF07728.9 CCF33177.1 - 0.0044 16.7 0.0 0.0098 15.6 0.0 1.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) MobB PF03205.9 CCF33177.1 - 0.0061 16.2 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 CCF33177.1 - 0.015 15.2 0.0 0.036 13.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.13 CCF33177.1 - 0.016 14.7 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.17 CCF33177.1 - 0.024 14.7 0.0 0.041 14.0 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_10 PF12846.2 CCF33177.1 - 0.035 13.5 0.1 0.13 11.6 0.0 1.8 1 1 1 2 2 2 0 AAA-like domain SRP54 PF00448.17 CCF33177.1 - 0.039 13.4 0.0 0.068 12.6 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain TrwB_AAD_bind PF10412.4 CCF33177.1 - 0.04 12.5 0.0 0.066 11.8 0.0 1.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_24 PF13479.1 CCF33177.1 - 0.048 13.2 0.1 0.095 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.6 CCF33177.1 - 0.05 13.2 0.1 0.15 11.7 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATP_bind_1 PF03029.12 CCF33177.1 - 0.067 12.7 0.2 0.15 11.5 0.0 1.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein ArgK PF03308.11 CCF33177.1 - 0.083 11.6 0.1 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 ArgK protein Cytidylate_kin2 PF13189.1 CCF33177.1 - 0.089 12.7 0.0 0.13 12.1 0.0 1.6 1 1 0 1 1 1 0 Cytidylate kinase-like family AAA_19 PF13245.1 CCF33177.1 - 0.098 12.4 0.2 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 Part of AAA domain Ham1p_like PF01725.11 CCF33178.1 - 1.5e-49 167.9 0.0 1.7e-49 167.7 0.0 1.0 1 0 0 1 1 1 1 Ham1 family DUF3820 PF12843.2 CCF33178.1 - 0.11 12.0 0.1 0.27 10.8 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3820) Peptidase_C78 PF07910.8 CCF33179.1 - 1.7e-47 161.4 0.0 2.3e-47 160.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C78 zf-Di19 PF05605.7 CCF33179.1 - 0.005 16.9 1.3 0.013 15.6 0.1 2.1 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.1 CCF33179.1 - 0.11 12.8 0.1 0.6 10.5 0.0 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF33179.1 - 0.26 11.7 0.8 0.51 10.7 0.0 2.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type Ras PF00071.17 CCF33180.1 - 3.9e-46 156.3 0.1 4.5e-46 156.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF33180.1 - 6.3e-15 55.7 0.1 8.4e-15 55.3 0.1 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CCF33180.1 - 2.1e-07 30.3 0.0 2.5e-07 30.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 CCF33180.1 - 1.2e-06 28.1 0.1 6.6e-06 25.6 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CCF33180.1 - 2.4e-06 27.4 0.1 4.1e-06 26.7 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 CCF33180.1 - 0.00064 18.9 0.0 0.0016 17.6 0.0 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_14 PF13173.1 CCF33180.1 - 0.0052 16.6 0.0 0.0079 16.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 CCF33180.1 - 0.08 12.6 0.1 0.11 12.1 0.1 1.5 1 1 0 1 1 1 0 Archaeal ATPase AAA_28 PF13521.1 CCF33180.1 - 0.12 12.3 0.0 0.44 10.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain PI-PLC-X PF00388.14 CCF33181.1 - 1.2e-58 196.6 0.0 1.9e-58 196.0 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 CCF33181.1 - 8.6e-37 125.7 0.0 1.9e-36 124.5 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain Cupin_2 PF07883.6 CCF33182.1 - 1.6e-05 24.3 0.6 2e-05 23.9 0.4 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.14 CCF33182.1 - 0.16 11.6 0.6 0.18 11.4 0.4 1.2 1 0 0 1 1 1 0 AraC-like ligand binding domain VHS PF00790.14 CCF33183.1 - 6.6e-46 155.4 0.2 2.8e-45 153.3 0.0 2.1 3 0 0 3 3 3 1 VHS domain GAT PF03127.9 CCF33183.1 - 8.7e-24 83.4 2.1 2.3e-23 82.0 1.4 1.7 1 0 0 1 1 1 1 GAT domain Alpha_adaptinC2 PF02883.15 CCF33183.1 - 4.7e-16 59.1 0.0 2.2e-15 56.9 0.0 2.1 2 0 0 2 2 2 1 Adaptin C-terminal domain DUF605 PF04652.11 CCF33183.1 - 3.1 7.1 22.6 5.6 6.2 15.7 1.4 1 1 0 1 1 1 0 Vta1 like DUF367 PF04034.8 CCF33184.1 - 9.2e-48 161.0 0.0 1.3e-47 160.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF367) RLI PF04068.10 CCF33184.1 - 4.4e-11 42.1 1.1 9.5e-11 41.0 0.7 1.6 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI BUD22 PF09073.5 CCF33184.1 - 8.6 5.3 25.7 12 4.7 17.8 1.2 1 0 0 1 1 1 0 BUD22 GTP_EFTU PF00009.22 CCF33185.1 - 2.1e-39 134.9 4.0 1.1e-38 132.6 2.8 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 CCF33185.1 - 2.4e-25 88.5 2.4 5.8e-25 87.2 1.7 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 CCF33185.1 - 1.1e-09 38.2 4.1 0.00019 21.4 0.7 3.2 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 CCF33185.1 - 5.2e-08 32.8 0.2 1.5e-07 31.3 0.1 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase IF2_N PF04760.10 CCF33185.1 - 3.1e-07 29.9 0.0 1e-06 28.2 0.0 2.0 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region Miro PF08477.8 CCF33185.1 - 7e-07 29.7 0.1 1.6e-06 28.6 0.1 1.6 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CCF33185.1 - 7.7e-05 21.9 0.0 0.00014 21.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 CCF33185.1 - 0.00013 21.2 0.5 0.0004 19.6 0.3 1.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 CCF33185.1 - 0.00039 19.8 0.2 0.0007 19.0 0.1 1.4 1 0 0 1 1 1 1 Ras family PduV-EutP PF10662.4 CCF33185.1 - 0.00063 19.2 0.3 0.0015 18.0 0.2 1.6 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.13 CCF33185.1 - 0.00092 18.5 0.3 0.003 16.8 0.2 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU_D4 PF14578.1 CCF33185.1 - 0.0013 18.3 0.7 0.0013 18.3 0.5 2.8 3 0 0 3 3 3 1 Elongation factor Tu domain 4 Dynamin_N PF00350.18 CCF33185.1 - 2.4 7.9 8.9 3.4 7.4 0.0 3.7 3 1 1 4 4 4 0 Dynamin family Rax2 PF12768.2 CCF33186.1 - 0.088 12.0 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity PP28 PF10252.4 CCF33187.1 - 5.7e-24 83.9 17.7 5.7e-24 83.9 12.3 3.3 3 0 0 3 3 3 2 Casein kinase substrate phosphoprotein PP28 CoA_trans PF01144.18 CCF33190.1 - 8.8e-97 322.5 0.9 1.8e-58 197.2 0.0 2.0 2 0 0 2 2 2 2 Coenzyme A transferase BNR_2 PF13088.1 CCF33193.1 - 1.8e-05 24.2 0.3 0.0066 15.7 0.1 2.2 1 1 1 2 2 2 2 BNR repeat-like domain BNR PF02012.15 CCF33193.1 - 4.4e-05 22.7 1.1 0.55 10.2 0.0 3.9 3 0 0 3 3 3 2 BNR/Asp-box repeat Glyco_hydro_35 PF01301.14 CCF33194.1 - 2.7e-84 283.2 0.2 3.7e-84 282.8 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom2 PF10435.4 CCF33194.1 - 5.2e-53 179.1 4.7 8.2e-53 178.4 3.2 1.3 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom4_5 PF13364.1 CCF33194.1 - 4e-29 101.1 1.9 1.3e-28 99.5 1.3 2.0 1 0 0 1 1 1 1 Beta-galactosidase jelly roll domain BetaGal_dom3 PF13363.1 CCF33194.1 - 1.1e-19 69.6 0.2 4.6e-19 67.5 0.1 2.1 2 0 0 2 2 2 1 Beta-galactosidase, domain 3 SGL PF08450.7 CCF33196.1 - 0.00054 19.4 0.1 0.0098 15.2 0.0 2.4 2 0 0 2 2 2 1 SMP-30/Gluconolaconase/LRE-like region GSDH PF07995.6 CCF33196.1 - 0.00086 18.4 0.4 0.012 14.7 0.2 2.8 1 1 1 2 2 2 1 Glucose / Sorbosone dehydrogenase Dor1 PF04124.7 CCF33197.1 - 1.1e-56 191.8 0.3 5.7e-45 153.2 1.5 2.1 2 0 0 2 2 2 2 Dor1-like family TRAM_LAG1_CLN8 PF03798.11 CCF33198.1 - 1.3e-46 158.7 15.4 1.3e-46 158.7 10.7 1.5 2 0 0 2 2 2 1 TLC domain SHD1 PF03983.7 CCF33199.1 - 1.5e-37 127.0 0.1 2.7e-37 126.2 0.1 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_1 PF00018.23 CCF33199.1 - 2.4e-35 119.6 8.0 2.9e-13 48.9 0.1 4.2 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.1 CCF33199.1 - 1.2e-33 114.3 9.5 4.5e-12 45.3 0.2 3.9 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.12 CCF33199.1 - 1.2e-25 88.7 0.3 1.3e-08 34.1 0.0 4.3 4 0 0 4 4 4 3 Variant SH3 domain SH3_3 PF08239.6 CCF33199.1 - 1.2e-05 25.3 6.0 0.025 14.7 0.7 3.5 3 0 0 3 3 3 2 Bacterial SH3 domain DUF1720 PF08226.6 CCF33199.1 - 0.00052 20.0 30.3 0.00052 20.0 21.0 6.5 2 1 2 5 5 5 2 Domain of unknown function (DUF1720) Lum_binding PF00677.12 CCF33200.1 - 3.8e-38 129.2 0.0 1.4e-20 72.9 0.0 2.1 2 0 0 2 2 2 2 Lumazine binding domain ERCC4 PF02732.10 CCF33201.1 - 6.2e-29 100.5 0.1 9.5e-29 99.9 0.1 1.3 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.1 CCF33201.1 - 0.00012 22.1 0.0 0.00028 21.0 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain HTH_27 PF13463.1 CCF33201.1 - 0.063 13.6 0.0 0.2 11.9 0.0 1.9 1 0 0 1 1 1 0 Winged helix DNA-binding domain PGM_PMM_I PF02878.11 CCF33202.1 - 3.1e-17 62.3 0.2 3.2e-07 29.9 0.0 2.9 1 1 2 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 CCF33202.1 - 3.1e-13 49.9 0.2 1.2e-12 48.0 0.1 2.1 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 CCF33202.1 - 1.6e-09 37.5 0.5 4.1e-09 36.3 0.1 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.11 CCF33202.1 - 0.0012 18.9 0.0 0.0029 17.6 0.0 1.7 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Sugar_tr PF00083.19 CCF33203.1 - 2.7e-80 270.1 21.8 3.6e-80 269.7 15.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF33203.1 - 1.4e-15 56.9 56.8 4.1e-14 52.0 18.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily UPF0233 PF06781.7 CCF33203.1 - 4.9 6.8 6.6 1.7 8.3 0.1 3.3 3 1 0 3 3 3 0 Uncharacterised protein family (UPF0233) DUF2456 PF10445.4 CCF33203.1 - 7 6.6 8.5 0.74 9.7 0.4 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2456) FRQ PF09421.5 CCF33204.1 - 0 1094.7 53.1 0 1094.4 36.8 1.0 1 0 0 1 1 1 1 Frequency clock protein PTS_2-RNA PF01885.11 CCF33204.1 - 0.0024 17.2 0.0 0.0041 16.4 0.0 1.3 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Inhibitor_I9 PF05922.11 CCF33205.1 - 0.12 12.9 0.0 0.14 12.7 0.0 1.2 1 0 0 1 1 1 0 Peptidase inhibitor I9 F_actin_bind PF08919.5 CCF33206.1 - 0.14 11.8 0.0 0.17 11.5 0.0 1.1 1 0 0 1 1 1 0 F-actin binding HOOK PF05622.7 CCF33207.1 - 0.00014 19.8 92.5 0.07 10.9 0.2 4.1 2 1 1 4 4 4 3 HOOK protein Reo_sigmaC PF04582.7 CCF33207.1 - 1.2 8.2 18.3 1.2 8.2 0.8 4.2 2 2 2 4 4 4 0 Reovirus sigma C capsid protein ADK_lid PF05191.9 CCF33208.1 - 1.9e-14 52.9 0.0 5.3e-14 51.5 0.0 1.7 2 0 0 2 2 2 1 Adenylate kinase, active site lid ADK PF00406.17 CCF33208.1 - 5e-12 45.9 0.0 6.2e-12 45.6 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase CN_hydrolase PF00795.17 CCF33209.1 - 1.8e-34 118.7 0.0 2.4e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Rsa3 PF14615.1 CCF33209.1 - 0.14 11.4 0.0 0.3 10.4 0.0 1.5 1 0 0 1 1 1 0 Ribosome-assembly protein 3 DUF1446 PF07287.6 CCF33210.1 - 1.1e-120 402.4 0.1 1.4e-120 402.1 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1446) Sugar_tr PF00083.19 CCF33211.1 - 2e-36 125.5 14.0 1.5e-19 69.9 0.1 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 CCF33211.1 - 1.9e-09 36.7 19.8 0.00012 20.8 0.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Condensation PF00668.15 CCF33212.1 - 4e-90 301.7 0.0 1.3e-61 208.0 0.0 2.5 2 1 0 2 2 2 2 Condensation domain AMP-binding PF00501.23 CCF33212.1 - 2e-85 286.6 0.1 3.4e-85 285.9 0.1 1.4 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.20 CCF33212.1 - 5.1e-25 87.5 0.2 3.5e-11 43.2 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site HxxPF_rpt PF13745.1 CCF33212.1 - 3.9e-23 81.5 0.1 1.2e-22 80.0 0.0 1.9 1 0 0 1 1 1 1 HxxPF-repeated domain AMP-binding_C PF13193.1 CCF33212.1 - 3.1e-10 40.8 0.5 0.0016 19.3 0.0 3.2 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain Methyltransf_23 PF13489.1 CCF33212.1 - 5.7e-05 22.9 0.0 0.0043 16.7 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF33212.1 - 0.00011 22.1 0.2 0.0043 17.0 0.0 3.1 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF33212.1 - 0.012 16.2 0.0 0.057 13.9 0.0 2.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 CCF33212.1 - 0.012 16.0 0.0 0.035 14.5 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.1 CCF33212.1 - 0.02 15.2 0.0 0.068 13.5 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 CCF33212.1 - 0.04 13.5 0.0 0.082 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Acetyltransf_1 PF00583.19 CCF33213.1 - 1.2e-14 54.0 0.0 2e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF33213.1 - 3.4e-11 43.1 0.0 5e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CCF33213.1 - 5.7e-08 32.8 0.1 7e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 CCF33213.1 - 2.4e-06 27.5 0.0 3.3e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF33213.1 - 0.00013 21.6 0.0 0.00021 20.9 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.1 CCF33213.1 - 0.00017 21.7 0.0 0.00025 21.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 CCF33213.1 - 0.0023 17.9 0.0 0.0025 17.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 CCF33213.1 - 0.0082 16.0 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.1 CCF33213.1 - 0.062 13.1 0.0 0.16 11.7 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Aminotran_4 PF01063.14 CCF33214.1 - 8.8e-12 44.9 0.0 1.2e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class IV DUF1067 PF06362.6 CCF33215.1 - 0.35 11.4 1.7 0.45 11.1 0.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1067) PSII_BNR PF14870.1 CCF33216.1 - 4e-09 35.9 3.3 7.2e-06 25.2 0.1 3.4 3 1 1 4 4 4 2 Photosynthesis system II assembly factor YCF48 BNR PF02012.15 CCF33216.1 - 4e-06 25.8 19.9 0.25 11.2 0.4 5.9 5 0 0 5 5 5 3 BNR/Asp-box repeat BNR_2 PF13088.1 CCF33216.1 - 7.6e-05 22.1 1.4 0.011 15.0 0.1 3.0 1 1 1 2 2 2 2 BNR repeat-like domain Mo-co_dimer PF03404.11 CCF33216.1 - 0.037 13.6 4.4 8.7 5.9 0.0 4.3 4 1 0 5 5 5 0 Mo-co oxidoreductase dimerisation domain zf-C3HC4_2 PF13923.1 CCF33219.1 - 0.019 14.9 5.4 0.038 14.0 3.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF33219.1 - 0.062 12.9 8.1 0.17 11.5 5.6 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF33219.1 - 0.15 11.8 7.3 0.24 11.1 5.1 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.1 CCF33219.1 - 0.37 10.6 6.5 0.093 12.6 1.8 1.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING FYVE PF01363.16 CCF33219.1 - 1.1 9.2 7.5 2.9 7.8 4.9 1.9 1 1 1 2 2 2 0 FYVE zinc finger HSP70 PF00012.15 CCF33220.1 - 0.00056 17.9 0.0 0.0093 13.9 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein BRF1 PF07741.8 CCF33220.1 - 0.055 13.6 0.4 0.1 12.8 0.3 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain ADIP PF11559.3 CCF33221.1 - 5.8e-05 23.0 13.1 9.6e-05 22.3 9.1 1.3 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.4 CCF33221.1 - 0.00045 20.0 13.8 0.0024 17.7 6.9 2.8 2 1 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Filament PF00038.16 CCF33221.1 - 0.0033 16.9 11.3 0.0033 16.9 7.8 1.9 1 1 1 2 2 2 2 Intermediate filament protein GAS PF13851.1 CCF33221.1 - 0.0048 16.1 10.0 0.0091 15.2 6.9 1.4 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Leu_zip PF15294.1 CCF33221.1 - 0.011 14.8 11.3 0.022 13.8 7.9 1.5 1 0 0 1 1 1 0 Leucine zipper DUF3479 PF11965.3 CCF33221.1 - 0.013 15.3 1.9 0.23 11.2 0.3 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF3479) CALCOCO1 PF07888.6 CCF33221.1 - 0.015 13.6 8.1 0.022 13.0 5.6 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like IFT57 PF10498.4 CCF33221.1 - 0.015 14.0 6.7 0.024 13.3 4.7 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Rab5-bind PF09311.6 CCF33221.1 - 0.018 14.9 11.4 0.069 13.0 6.7 2.2 2 1 0 2 2 2 0 Rabaptin-like protein Mnd1 PF03962.10 CCF33221.1 - 0.026 14.1 11.3 0.041 13.5 6.3 2.2 2 1 1 3 3 2 0 Mnd1 family Myosin_tail_1 PF01576.14 CCF33221.1 - 0.027 12.2 12.0 0.046 11.4 8.3 1.3 1 0 0 1 1 1 0 Myosin tail Laminin_I PF06008.9 CCF33221.1 - 0.028 13.7 8.7 0.045 13.0 6.1 1.3 1 0 0 1 1 1 0 Laminin Domain I TACC PF05010.9 CCF33221.1 - 0.028 14.1 9.0 0.058 13.1 6.2 1.5 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) Reo_sigmaC PF04582.7 CCF33221.1 - 0.029 13.5 1.1 0.052 12.7 0.8 1.5 1 0 0 1 1 1 0 Reovirus sigma C capsid protein CRISPR_Cse1 PF09481.5 CCF33221.1 - 0.033 12.9 1.8 0.053 12.2 1.2 1.2 1 0 0 1 1 1 0 CRISPR-associated protein Cse1 (CRISPR_cse1) Med9 PF07544.8 CCF33221.1 - 0.036 13.7 10.8 1.4 8.6 0.4 3.2 1 1 2 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 AAA_13 PF13166.1 CCF33221.1 - 0.036 12.5 10.9 0.055 11.9 7.5 1.2 1 0 0 1 1 1 0 AAA domain DUF4200 PF13863.1 CCF33221.1 - 0.062 13.2 18.5 0.11 12.4 8.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) CCDC155 PF14662.1 CCF33221.1 - 0.074 12.6 10.0 0.22 11.0 4.3 2.3 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 Laminin_II PF06009.7 CCF33221.1 - 0.077 12.7 10.1 0.048 13.4 3.6 2.3 1 1 0 2 2 2 0 Laminin Domain II Rootletin PF15035.1 CCF33221.1 - 0.11 12.4 14.0 0.18 11.8 6.6 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Tropomyosin_1 PF12718.2 CCF33221.1 - 0.13 12.0 13.3 0.39 10.5 9.0 1.9 1 1 0 1 1 1 0 Tropomyosin like WD40_alt PF14077.1 CCF33221.1 - 0.14 11.8 1.5 1.2 8.7 0.3 2.5 1 1 1 2 2 2 0 Alternative WD40 repeat motif Syntaxin-6_N PF09177.6 CCF33221.1 - 0.19 12.1 5.7 0.48 10.8 3.9 1.7 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Jnk-SapK_ap_N PF09744.4 CCF33221.1 - 0.2 11.6 13.8 0.38 10.7 8.4 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 H-kinase_dim PF02895.9 CCF33221.1 - 0.2 11.9 1.6 0.57 10.5 1.1 1.8 1 0 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain IncA PF04156.9 CCF33221.1 - 0.24 10.9 11.5 0.52 9.8 8.0 1.6 1 0 0 1 1 1 0 IncA protein Mto2_bdg PF12808.2 CCF33221.1 - 0.28 11.3 11.1 1.2 9.2 0.5 3.6 2 1 1 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Herpes_BLRF2 PF05812.7 CCF33221.1 - 0.3 10.8 9.8 0.76 9.5 0.3 3.3 1 1 2 3 3 3 0 Herpesvirus BLRF2 protein BLOC1_2 PF10046.4 CCF33221.1 - 0.31 11.2 6.4 0.81 9.8 4.3 1.9 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Lectin_N PF03954.9 CCF33221.1 - 0.33 10.3 7.2 4.8 6.5 5.0 2.4 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain DUF2968 PF11180.3 CCF33221.1 - 0.42 9.9 10.8 0.13 11.5 5.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) FlaC_arch PF05377.6 CCF33221.1 - 0.43 10.5 6.6 18 5.3 4.4 3.3 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) bZIP_2 PF07716.10 CCF33221.1 - 0.5 10.2 17.1 0.47 10.3 1.2 4.2 2 1 2 4 4 4 0 Basic region leucine zipper ATG16 PF08614.6 CCF33221.1 - 0.54 10.0 14.9 0.6 9.8 6.5 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.7 CCF33221.1 - 0.55 9.9 15.1 0.15 11.7 5.4 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein NPV_P10 PF05531.7 CCF33221.1 - 0.57 10.4 3.3 7.3 6.9 0.1 3.0 2 1 1 3 3 2 0 Nucleopolyhedrovirus P10 protein APG6 PF04111.7 CCF33221.1 - 0.59 9.1 11.0 0.9 8.5 7.6 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Phage_GP20 PF06810.6 CCF33221.1 - 0.6 9.5 13.4 6.7 6.1 9.0 2.4 1 1 0 1 1 1 0 Phage minor structural protein GP20 Ax_dynein_light PF10211.4 CCF33221.1 - 0.74 9.6 12.7 2.3 8.0 8.6 2.0 1 1 1 2 2 2 0 Axonemal dynein light chain DUF972 PF06156.8 CCF33221.1 - 0.83 10.0 10.8 9.5 6.6 6.4 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF972) HemX PF04375.9 CCF33221.1 - 0.88 8.0 12.4 0.12 10.9 4.5 2.1 1 1 1 2 2 2 0 HemX DUF904 PF06005.7 CCF33221.1 - 0.88 9.9 15.2 5.2 7.4 3.4 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF904) Cortex-I_coil PF09304.5 CCF33221.1 - 1.2 9.1 10.6 1 9.4 5.6 2.1 1 1 1 2 2 2 0 Cortexillin I, coiled coil V_ATPase_I PF01496.14 CCF33221.1 - 1.5 6.6 4.9 2.1 6.1 3.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3573 PF12097.3 CCF33221.1 - 2.1 6.8 5.6 20 3.6 3.8 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) DUF1319 PF07028.6 CCF33221.1 - 2.3 8.4 11.7 2.1 8.5 2.0 2.8 1 1 1 3 3 2 0 Protein of unknown function (DUF1319) Prefoldin_2 PF01920.15 CCF33221.1 - 2.4 7.9 14.2 3.3 7.5 3.2 2.9 1 1 0 1 1 1 0 Prefoldin subunit DUF3450 PF11932.3 CCF33221.1 - 2.8 7.1 11.0 4.3 6.5 7.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) SlyX PF04102.7 CCF33221.1 - 3 8.2 11.0 4.5 7.7 0.4 3.4 2 1 1 3 3 3 0 SlyX DivIC PF04977.10 CCF33221.1 - 3.6 7.1 15.6 2.2 7.8 1.4 3.6 1 1 2 3 3 3 0 Septum formation initiator CENP-Q PF13094.1 CCF33221.1 - 3.6 7.5 12.1 13 5.7 8.0 2.1 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Cep57_CLD_2 PF14197.1 CCF33221.1 - 4.4 7.3 11.0 20 5.2 2.4 3.7 3 1 1 4 4 4 0 Centrosome localisation domain of PPC89 Bap31 PF05529.7 CCF33221.1 - 4.8 6.5 11.7 27 4.1 8.1 2.2 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like Fzo_mitofusin PF04799.8 CCF33221.1 - 5.1 6.4 8.7 2 7.7 0.4 2.3 1 1 1 2 2 2 0 fzo-like conserved region Tup_N PF08581.5 CCF33221.1 - 5.6 7.2 11.5 14 5.9 2.7 3.3 2 1 1 4 4 2 0 Tup N-terminal bZIP_1 PF00170.16 CCF33221.1 - 5.8 6.9 12.0 7.3 6.6 2.8 3.7 2 1 1 3 3 3 0 bZIP transcription factor Atg14 PF10186.4 CCF33221.1 - 7.6 5.3 15.4 23 3.7 10.7 1.8 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Aminotran_1_2 PF00155.16 CCF33222.1 - 4.5e-35 121.2 0.0 6e-35 120.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 CCF33222.1 - 2.8e-05 23.4 0.0 4.6e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 CCF33222.1 - 0.00034 19.0 0.0 0.00052 18.4 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 CCF33222.1 - 0.024 13.3 0.0 0.043 12.5 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V Alliinase_C PF04864.8 CCF33222.1 - 0.055 12.1 0.5 0.13 10.9 0.4 1.6 1 1 0 1 1 1 0 Allinase DegT_DnrJ_EryC1 PF01041.12 CCF33222.1 - 0.091 11.7 0.0 0.13 11.2 0.0 1.1 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family CR6_interact PF10147.4 CCF33223.1 - 0.00056 19.3 2.3 0.001 18.4 1.6 1.5 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 RCR PF12273.3 CCF33223.1 - 0.0036 17.8 0.1 0.0036 17.8 0.1 2.5 2 1 0 2 2 2 1 Chitin synthesis regulation, resistance to Congo red HNH_2 PF13391.1 CCF33224.1 - 8.2e-11 41.5 0.0 1.7e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease Fungal_trans PF04082.13 CCF33225.1 - 3.7e-07 29.2 0.1 6.4e-07 28.5 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain ketoacyl-synt PF00109.21 CCF33226.1 - 1.2e-70 237.9 0.0 2.3e-70 236.9 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.1 CCF33226.1 - 4.5e-66 223.0 1.4 7.3e-66 222.3 0.0 2.0 2 0 0 2 2 2 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.16 CCF33226.1 - 6e-58 196.6 0.1 1.2e-57 195.6 0.1 1.5 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.5 CCF33226.1 - 7.5e-57 191.9 0.1 2e-56 190.4 0.1 1.8 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 CCF33226.1 - 3.5e-47 160.4 1.3 8.2e-47 159.2 0.2 2.3 2 0 0 2 2 2 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 CCF33226.1 - 1.1e-29 102.6 0.2 4e-29 100.8 0.1 2.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_N PF08240.7 CCF33226.1 - 6e-05 22.7 0.0 0.00014 21.5 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.18 CCF33226.1 - 0.00023 20.2 0.3 0.00044 19.3 0.2 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 CCF33226.1 - 0.0061 16.1 0.8 0.024 14.2 0.5 2.1 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PP-binding PF00550.20 CCF33226.1 - 0.024 14.8 0.2 0.08 13.2 0.1 2.0 1 0 0 1 1 1 0 Phosphopantetheine attachment site DNA_gyraseB_C PF00986.16 CCF33226.1 - 0.32 10.7 0.0 0.79 9.5 0.0 1.6 1 0 0 1 1 1 0 DNA gyrase B subunit, carboxyl terminus Pyr_redox_3 PF13738.1 CCF33227.1 - 7.1e-25 88.2 0.0 2.3e-24 86.5 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 CCF33227.1 - 1.1e-11 43.6 0.0 2.7e-06 25.8 0.0 2.4 3 0 0 3 3 3 2 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.1 CCF33227.1 - 1.5e-08 34.5 0.1 3.9e-06 26.7 0.0 3.4 3 1 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 CCF33227.1 - 1.2e-07 31.7 0.0 1.5e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF33227.1 - 2.7e-07 29.8 0.0 1.8e-06 27.1 0.0 2.2 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.9 CCF33227.1 - 0.00024 19.6 0.0 0.44 8.9 0.0 2.3 2 0 0 2 2 2 2 HI0933-like protein Lycopene_cycl PF05834.7 CCF33227.1 - 0.00046 19.2 0.0 0.3 9.9 0.0 2.8 3 0 0 3 3 3 2 Lycopene cyclase protein NAD_binding_8 PF13450.1 CCF33227.1 - 0.037 14.0 0.0 0.11 12.5 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF33227.1 - 0.065 12.1 0.2 4.8 5.9 0.1 2.8 3 1 1 4 4 4 0 FAD dependent oxidoreductase Thi4 PF01946.12 CCF33227.1 - 0.066 12.3 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Amino_oxidase PF01593.19 CCF33227.1 - 0.081 11.9 0.0 12 4.8 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase GIDA PF01134.17 CCF33227.1 - 0.22 10.3 0.2 2.3 6.9 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A MFS_1 PF07690.11 CCF33228.1 - 2.7e-35 121.7 51.5 2.7e-35 121.7 35.7 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF33228.1 - 1.5e-07 30.3 13.8 1.5e-07 30.3 9.5 3.6 3 1 0 3 3 3 1 Sugar (and other) transporter Homeobox_KN PF05920.6 CCF33229.1 - 1.8e-14 53.1 1.1 1.8e-14 53.1 0.7 3.2 3 0 0 3 3 3 1 Homeobox KN domain HTH_Tnp_Tc5 PF03221.11 CCF33229.1 - 5.8e-12 45.2 2.0 0.00079 19.1 0.0 4.9 4 1 0 4 4 4 2 Tc5 transposase DNA-binding domain Homeobox PF00046.24 CCF33229.1 - 8.7e-06 25.2 0.6 2.7e-05 23.6 0.4 1.9 1 0 0 1 1 1 1 Homeobox domain zf-C2H2_4 PF13894.1 CCF33229.1 - 0.015 15.5 4.2 0.015 15.5 2.9 4.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF33229.1 - 0.21 12.0 24.8 0.035 14.4 2.6 4.5 3 1 1 4 4 4 0 Zinc finger, C2H2 type DUF3425 PF11905.3 CCF33230.1 - 1.4e-24 86.5 0.3 2.3e-24 85.7 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) SNase PF00565.12 CCF33231.1 - 3.9e-75 249.0 0.7 2e-21 76.2 0.0 5.4 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.19 CCF33231.1 - 2.1e-24 85.7 0.0 4.1e-24 84.7 0.0 1.4 1 0 0 1 1 1 1 Tudor domain SMN PF06003.7 CCF33231.1 - 9.3e-06 24.9 0.0 2e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) RNA_pol_Rpb1_3 PF04983.13 CCF33231.1 - 0.087 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 3 Sod_Cu PF00080.15 CCF33232.1 - 4.7e-44 149.9 7.2 5.5e-44 149.7 5.0 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Glyco_hydro_71 PF03659.9 CCF33234.1 - 4.9e-156 519.0 5.5 7.4e-156 518.4 3.8 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 LysM PF01476.15 CCF33235.1 - 4.1e-08 32.9 0.0 0.016 15.1 0.0 2.6 2 0 0 2 2 2 2 LysM domain ET PF01684.11 CCF33235.1 - 0.052 13.5 1.7 6.6 6.8 0.1 2.9 2 0 0 2 2 2 0 ET module KR PF08659.5 CCF33236.1 - 1.2e-56 191.3 0.0 1.7e-56 190.7 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 CCF33236.1 - 1.1e-46 158.7 0.1 2e-46 157.9 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase ADH_zinc_N PF00107.21 CCF33236.1 - 1.5e-12 47.1 0.3 6.3e-12 45.1 0.0 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF33236.1 - 3.1e-11 44.2 0.0 6.4e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.20 CCF33236.1 - 4.8e-08 33.1 0.1 1e-07 32.0 0.1 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site Arginase PF00491.16 CCF33237.1 - 1.4e-19 70.4 0.1 1.6e-19 70.3 0.0 1.0 1 0 0 1 1 1 1 Arginase family CFEM PF05730.6 CCF33239.1 - 1.2e-05 24.9 7.6 2e-05 24.3 5.3 1.3 1 0 0 1 1 1 1 CFEM domain HAD_2 PF13419.1 CCF33240.1 - 6.2e-14 52.6 0.0 2.5e-13 50.6 0.0 1.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CCF33240.1 - 2.1e-07 31.5 0.0 1.4e-05 25.6 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CCF33240.1 - 3.2e-07 29.9 0.0 5.5e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like RCC1 PF00415.13 CCF33240.1 - 0.047 13.8 0.1 0.21 11.7 0.0 2.1 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat NB-ARC PF00931.17 CCF33241.1 - 1.8e-11 43.4 0.0 2.5e-10 39.7 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain TPR_12 PF13424.1 CCF33241.1 - 1.1e-05 25.2 2.2 0.22 11.4 0.3 3.8 2 1 1 3 3 3 2 Tetratricopeptide repeat AAA_22 PF13401.1 CCF33241.1 - 0.00022 21.3 0.0 0.0037 17.4 0.0 2.6 3 0 0 3 3 3 1 AAA domain Abhydrolase_6 PF12697.2 CCF33241.1 - 0.0014 18.5 0.0 0.0044 16.9 0.0 1.9 1 0 0 1 1 1 1 Alpha/beta hydrolase family AAA_16 PF13191.1 CCF33241.1 - 0.0018 18.2 0.1 0.0094 15.9 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain PGAP1 PF07819.8 CCF33241.1 - 0.0039 16.7 0.0 0.013 15.1 0.0 1.8 2 0 0 2 2 2 1 PGAP1-like protein DUF676 PF05057.9 CCF33241.1 - 0.0053 16.0 0.0 0.0099 15.1 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) CorA PF01544.13 CCF33242.1 - 1.3e-12 47.4 0.1 2.1e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein 2HCT PF03390.10 CCF33242.1 - 0.11 10.8 0.1 0.17 10.2 0.1 1.1 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family GMC_oxred_N PF00732.14 CCF33243.1 - 3.5e-64 216.8 0.3 5.2e-64 216.2 0.0 1.4 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF33243.1 - 3.5e-35 121.4 0.1 6.6e-35 120.5 0.1 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 CCF33243.1 - 2.6e-06 26.5 0.1 0.012 14.5 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 CCF33243.1 - 4.4e-06 25.8 0.2 8.7e-05 21.5 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF33243.1 - 0.004 17.1 0.3 0.015 15.3 0.2 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 CCF33243.1 - 0.0051 15.7 0.0 0.009 14.9 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.22 CCF33243.1 - 0.01 16.1 1.3 0.57 10.6 0.3 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 CCF33243.1 - 0.13 11.3 4.2 1 8.3 0.3 2.8 2 1 0 2 2 2 0 FAD dependent oxidoreductase Glyco_hydro_31 PF01055.21 CCF33244.1 - 5.5e-131 437.4 3.7 6.7e-131 437.1 2.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 CCF33244.1 - 7.7e-05 22.4 0.2 0.00053 19.7 0.0 2.6 2 1 0 2 2 2 1 Galactose mutarotase-like MFS_1 PF07690.11 CCF33245.1 - 1.2e-40 139.2 50.9 4.2e-40 137.5 31.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF33245.1 - 0.045 12.3 30.8 0.31 9.5 20.8 2.7 1 1 0 1 1 1 0 Sugar (and other) transporter Mad3_BUB1_I PF08311.7 CCF33246.1 - 7.5e-44 148.5 0.2 1.2e-43 147.8 0.1 1.3 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 F-box-like PF12937.2 CCF33247.1 - 0.00015 21.4 0.3 0.00037 20.1 0.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF33247.1 - 0.57 9.8 5.4 5.7 6.7 3.7 2.4 1 1 0 1 1 1 0 F-box domain Peptidase_S8 PF00082.17 CCF33248.1 - 5.4e-37 127.4 10.2 7.7e-37 126.9 7.1 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 CCF33248.1 - 4.3e-17 62.4 0.0 7.8e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 XFP_N PF09364.5 CCF33249.1 - 1e-133 445.6 0.0 5.8e-95 318.0 0.0 2.0 1 1 1 2 2 2 2 XFP N-terminal domain TPP_enzyme_C PF02775.16 CCF33249.1 - 0.00039 20.0 0.3 0.005 16.4 0.1 2.3 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain FAD_binding_4 PF01565.18 CCF33249.1 - 0.14 11.6 0.1 0.5 9.8 0.0 1.9 2 1 0 2 2 2 0 FAD binding domain Catalase PF00199.14 CCF33250.1 - 1.8e-160 533.8 0.3 2.4e-160 533.4 0.2 1.2 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.7 CCF33250.1 - 6e-20 70.8 0.1 1.2e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive DJ-1_PfpI PF01965.19 CCF33250.1 - 3.3e-07 29.8 0.0 6.3e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family DUF2140 PF09911.4 CCF33251.1 - 0.069 12.3 0.1 0.42 9.7 0.1 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) Glycoprotein_B PF00606.13 CCF33251.1 - 0.14 10.1 0.7 0.19 9.7 0.5 1.1 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B DUF1547 PF07577.6 CCF33251.1 - 0.41 10.3 7.7 0.44 10.2 0.2 3.7 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1547) DUF1180 PF06679.7 CCF33251.1 - 5.4 6.8 10.7 0.59 9.9 3.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Glyco_hydro_6 PF01341.12 CCF33252.1 - 2e-96 322.9 0.2 2.3e-96 322.7 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 Lipase_GDSL PF00657.17 CCF33253.1 - 1.3e-11 44.8 0.0 1.6e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase APH PF01636.18 CCF33254.1 - 9.9e-15 54.9 0.0 2.6e-14 53.5 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.15 CCF33254.1 - 0.0012 18.0 0.0 0.0019 17.3 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.6 CCF33254.1 - 0.026 13.1 0.0 0.05 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) RIO1 PF01163.17 CCF33254.1 - 0.1 11.9 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 RIO1 family SBP_bac_3 PF00497.15 CCF33255.1 - 1.6e-29 102.7 0.5 3e-29 101.8 0.3 1.4 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 O-antigen_lig PF13425.1 CCF33256.1 - 9.8 6.1 8.1 33 4.4 5.6 1.7 1 1 0 1 1 1 0 O-antigen ligase like membrane protein PCI PF01399.22 CCF33257.1 - 1.4e-08 34.9 0.0 2.9e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 PCI domain E1-E2_ATPase PF00122.15 CCF33259.1 - 9.7e-55 185.0 0.4 2.1e-54 184.0 0.1 1.7 2 0 0 2 2 2 1 E1-E2 ATPase HMA PF00403.21 CCF33259.1 - 1.6e-44 149.8 0.7 7e-12 45.3 0.0 4.6 4 0 0 4 4 4 4 Heavy-metal-associated domain Hydrolase PF00702.21 CCF33259.1 - 2.8e-44 152.0 1.6 6e-44 151.0 1.1 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 CCF33259.1 - 1.3e-14 54.7 0.0 2.6e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CCF33259.1 - 7.5e-05 22.4 1.5 0.00066 19.3 0.3 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase FAM70 PF14967.1 CCF33259.1 - 0.04 13.1 0.9 19 4.3 0.0 3.4 4 0 0 4 4 4 0 FAM70 protein DUF155 PF02582.9 CCF33260.1 - 3.6e-59 199.5 0.1 6e-59 198.8 0.1 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 RNase_P_p30 PF01876.11 CCF33262.1 - 3.3e-44 149.7 0.0 4.7e-44 149.2 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit p30 RNase_T PF00929.19 CCF33263.1 - 1.2e-21 77.6 0.0 1.8e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 Exonuclease CK1gamma_C PF12605.3 CCF33263.1 - 0.0076 16.7 2.2 0.018 15.5 1.5 1.6 1 0 0 1 1 1 1 Casein kinase 1 gamma C terminal RRP7 PF12923.2 CCF33263.1 - 0.022 14.8 0.1 0.065 13.2 0.1 1.8 1 0 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) Prefoldin PF02996.12 CCF33264.1 - 0.003 17.2 0.5 0.0041 16.7 0.3 1.3 1 1 0 1 1 1 1 Prefoldin subunit DUF948 PF06103.6 CCF33264.1 - 0.011 15.6 0.7 0.014 15.2 0.5 1.3 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) FliJ PF02050.11 CCF33264.1 - 0.076 13.0 0.2 0.13 12.3 0.1 1.3 1 0 0 1 1 1 0 Flagellar FliJ protein Atg14 PF10186.4 CCF33264.1 - 0.098 11.5 0.7 0.095 11.6 0.5 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DivIC PF04977.10 CCF33264.1 - 0.11 12.0 0.7 0.6 9.6 0.5 2.0 1 1 0 1 1 1 0 Septum formation initiator DUF2951 PF11166.3 CCF33264.1 - 0.29 11.0 2.1 0.38 10.6 1.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2951) zf-MYND PF01753.13 CCF33265.1 - 9.4e-09 35.0 10.4 9.4e-09 35.0 7.2 2.0 2 0 0 2 2 2 1 MYND finger SET PF00856.23 CCF33265.1 - 1.4e-06 28.6 0.0 3.4e-05 24.2 0.0 2.3 2 0 0 2 2 2 1 SET domain Gag_p10 PF02337.12 CCF33265.1 - 0.024 14.3 0.0 0.11 12.2 0.0 2.0 2 0 0 2 2 2 0 Retroviral GAG p10 protein MRL1 PF13003.2 CCF33265.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L1 SUI1 PF01253.17 CCF33266.1 - 2.4e-29 100.9 4.8 2.4e-29 100.9 3.3 1.4 2 0 0 2 2 2 1 Translation initiation factor SUI1 Polysacc_deac_1 PF01522.16 CCF33267.1 - 7.6e-26 90.1 0.1 2e-25 88.7 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.14 CCF33267.1 - 5.4e-06 26.2 16.7 5.4e-06 26.2 11.6 2.6 2 0 0 2 2 2 2 Chitin recognition protein BAF1_ABF1 PF04684.8 CCF33268.1 - 0.15 10.9 14.1 0.22 10.3 9.8 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor zf-C2H2 PF00096.21 CCF33268.1 - 0.78 10.2 13.8 0.083 13.2 0.8 3.3 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-met PF12874.2 CCF33268.1 - 1.7 8.9 11.4 0.99 9.7 0.4 3.4 4 0 0 4 4 4 0 Zinc-finger of C2H2 type TFIIA PF03153.8 CCF33268.1 - 4.7 6.9 21.2 0.062 13.1 6.5 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit ABC2_membrane PF01061.19 CCF33269.1 - 5.5e-25 87.7 9.2 7.2e-25 87.3 6.4 1.1 1 0 0 1 1 1 1 ABC-2 type transporter ABC_trans_N PF14510.1 CCF33269.1 - 1.2e-19 70.1 0.0 2.3e-19 69.2 0.0 1.5 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal ABC_tran PF00005.22 CCF33269.1 - 4.5e-08 33.4 0.0 1.1e-05 25.7 0.0 2.3 2 0 0 2 2 2 2 ABC transporter AAA_25 PF13481.1 CCF33269.1 - 0.015 14.6 0.1 0.029 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CCF33269.1 - 0.038 13.9 0.0 0.12 12.3 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain Dabb PF07876.7 CCF33270.1 - 2.7e-22 79.0 0.0 3.1e-22 78.8 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain p450 PF00067.17 CCF33272.1 - 1.5e-53 182.0 0.0 1.8e-53 181.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RNase_H PF00075.19 CCF33272.1 - 0.0062 16.8 0.1 0.012 15.9 0.1 1.4 1 0 0 1 1 1 1 RNase H NmrA PF05368.8 CCF33274.1 - 1.2e-21 77.0 0.0 1.5e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF33274.1 - 2.7e-15 56.8 0.0 4e-15 56.3 0.0 1.4 1 1 0 1 1 1 1 NADH(P)-binding DapB_N PF01113.15 CCF33274.1 - 0.00011 22.0 0.8 0.00048 20.0 0.3 2.0 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Saccharop_dh PF03435.13 CCF33274.1 - 0.00027 20.0 0.4 0.00055 19.0 0.1 1.6 2 0 0 2 2 2 1 Saccharopine dehydrogenase Epimerase PF01370.16 CCF33274.1 - 0.012 15.0 0.1 0.091 12.1 0.0 2.3 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.19 CCF33274.1 - 0.015 15.5 0.1 0.098 12.9 0.0 2.2 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Zn_clus PF00172.13 CCF33275.1 - 3.6e-07 29.9 6.8 7.3e-07 28.9 4.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tropomyosin_1 PF12718.2 CCF33277.1 - 0.0049 16.7 1.9 0.0049 16.7 1.3 1.8 2 0 0 2 2 2 1 Tropomyosin like Golgin_A5 PF09787.4 CCF33277.1 - 0.0076 14.8 0.8 0.012 14.2 0.6 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 5 DUF848 PF05852.6 CCF33277.1 - 0.038 13.8 1.9 0.081 12.7 1.3 1.5 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) CENP-F_leu_zip PF10473.4 CCF33277.1 - 0.12 12.1 4.2 0.25 11.1 2.9 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FUSC PF04632.7 CCF33277.1 - 0.21 9.9 1.2 0.35 9.2 0.8 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family GP41 PF00517.12 CCF33277.1 - 0.66 9.4 2.9 0.33 10.4 0.2 1.7 2 0 0 2 2 2 0 Retroviral envelope protein Fungal_trans PF04082.13 CCF33278.1 - 1.8e-12 46.6 0.0 3.1e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF33278.1 - 1.2e-07 31.5 13.4 2e-07 30.7 9.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HpcH_HpaI PF03328.9 CCF33279.1 - 7.8e-31 106.6 0.0 9.9e-31 106.3 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PEP-utilizers_C PF02896.13 CCF33279.1 - 0.12 11.1 0.1 0.86 8.4 0.1 2.4 1 1 1 2 2 2 0 PEP-utilising enzyme, TIM barrel domain OppC_N PF12911.2 CCF33280.1 - 0.00076 18.7 0.6 0.015 14.6 0.0 2.2 1 1 1 2 2 2 1 N-terminal TM domain of oligopeptide transport permease C DUF1275 PF06912.6 CCF33280.1 - 0.0013 18.0 0.0 0.0014 17.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) Tetraspannin PF00335.15 CCF33280.1 - 0.0038 16.5 0.2 0.0049 16.1 0.1 1.1 1 0 0 1 1 1 1 Tetraspanin family TMEM220 PF15071.1 CCF33280.1 - 0.014 15.8 0.0 0.017 15.5 0.0 1.1 1 0 0 1 1 1 0 Transmembrane family 220, helix Claudin_3 PF06653.6 CCF33280.1 - 0.039 13.6 1.0 0.048 13.3 0.7 1.1 1 0 0 1 1 1 0 Tight junction protein, Claudin-like AA_permease_2 PF13520.1 CCF33280.1 - 0.041 12.4 0.2 0.051 12.1 0.1 1.1 1 0 0 1 1 1 0 Amino acid permease Acyl_transf_3 PF01757.17 CCF33280.1 - 0.056 12.2 0.0 0.056 12.2 0.0 1.0 1 0 0 1 1 1 0 Acyltransferase family Asp-Al_Ex PF06826.7 CCF33280.1 - 0.058 12.8 0.0 0.071 12.6 0.0 1.1 1 0 0 1 1 1 0 Predicted Permease Membrane Region Colicin_V PF02674.11 CCF33280.1 - 0.084 12.7 0.1 1.2 8.9 0.0 2.0 2 0 0 2 2 2 0 Colicin V production protein DUF1516 PF07457.6 CCF33280.1 - 0.1 12.7 0.1 1.8 8.6 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1516) DUF4220 PF13968.1 CCF33280.1 - 0.13 11.3 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) Cys_Met_Meta_PP PF01053.15 CCF33281.1 - 5.1e-138 459.5 0.1 5.8e-138 459.3 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 CCF33281.1 - 1.1e-07 30.9 0.4 2.1e-07 30.0 0.3 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 CCF33281.1 - 1.5e-07 30.7 0.2 2.3e-07 30.1 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 CCF33281.1 - 4e-07 29.3 0.8 7.1e-07 28.5 0.6 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 CCF33281.1 - 0.00052 19.2 0.5 0.001 18.3 0.3 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.11 CCF33281.1 - 0.0034 16.1 0.2 0.0052 15.5 0.2 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein Semialdhyde_dh PF01118.19 CCF33281.1 - 0.084 13.1 0.3 6.2 7.1 0.0 2.4 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Peptidase_S58 PF03576.9 CCF33282.1 - 0.017 14.3 0.5 0.022 13.9 0.4 1.1 1 0 0 1 1 1 0 Peptidase family S58 Pkinase PF00069.20 CCF33283.1 - 2.1e-70 236.8 0.0 2.7e-70 236.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF33283.1 - 8.2e-33 113.5 0.3 2e-32 112.2 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF33283.1 - 0.00018 20.5 0.0 0.00029 19.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 CCF33283.1 - 0.0016 17.8 0.0 0.0044 16.3 0.0 1.7 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 CCF33283.1 - 0.002 17.2 0.0 0.0039 16.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Herpes_capsid PF06112.6 CCF33284.1 - 0.74 9.8 19.5 0.042 13.8 5.4 2.4 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein Condensation PF00668.15 CCF33285.1 - 9e-38 129.8 0.4 1.1e-37 129.5 0.3 1.1 1 0 0 1 1 1 1 Condensation domain MFS_1 PF07690.11 CCF33286.1 - 9.6e-17 60.7 14.3 1.2e-16 60.4 9.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily FA_desaturase PF00487.19 CCF33286.1 - 0.04 13.3 4.5 0.26 10.6 0.0 2.1 2 0 0 2 2 2 0 Fatty acid desaturase DUF1156 PF06634.7 CCF33286.1 - 0.13 12.0 0.7 0.75 9.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1156) CD20 PF04103.10 CCF33286.1 - 0.58 10.0 9.4 0.18 11.6 2.3 2.1 2 0 0 2 2 2 0 CD20-like family FAD_binding_4 PF01565.18 CCF33287.1 - 3.2e-20 72.0 2.5 4.2e-20 71.6 1.1 1.7 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.7 CCF33287.1 - 0.0041 16.9 0.1 0.0081 16.0 0.1 1.5 1 0 0 1 1 1 1 Berberine and berberine like RRM_1 PF00076.17 CCF33289.1 - 9.4e-84 275.0 6.0 2.9e-21 74.8 0.1 5.3 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF33289.1 - 7.7e-55 182.7 1.1 1e-14 54.2 0.0 5.3 5 0 0 5 5 5 5 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF33289.1 - 7.9e-41 137.7 0.0 2.3e-09 36.9 0.0 5.5 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CCF33289.1 - 0.00013 21.6 0.1 7.9 6.3 0.0 4.9 4 1 0 4 4 4 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 CCF33289.1 - 0.0003 20.4 2.7 2.8 7.7 0.1 3.5 3 0 0 3 3 3 2 Limkain b1 CbiG_mid PF11761.3 CCF33289.1 - 0.0011 19.1 4.3 4 7.7 0.0 3.9 4 0 0 4 4 4 2 Cobalamin biosynthesis central region PAT1 PF09770.4 CCF33289.1 - 0.0011 17.3 18.1 0.0016 16.8 12.6 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 OB_RNB PF08206.6 CCF33289.1 - 0.0037 16.7 1.4 5.1 6.6 0.0 3.7 3 0 0 3 3 3 1 Ribonuclease B OB domain Nab6_mRNP_bdg PF10567.4 CCF33289.1 - 0.01 14.8 1.1 0.02 13.9 0.2 1.9 2 0 0 2 2 2 0 RNA-recognition motif RNA_polI_A34 PF08208.6 CCF33289.1 - 0.21 11.2 16.1 0.43 10.2 11.2 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 HECT PF00632.20 CCF33290.1 - 8.9e-86 287.9 0.0 1.6e-85 287.0 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.22 CCF33290.1 - 0.00047 19.5 2.8 0.0012 18.3 1.9 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif DUF1237 PF06824.6 CCF33291.1 - 1.2e-163 544.6 0.0 1.4e-163 544.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1237) Glyco_hydro_92 PF07971.7 CCF33292.1 - 1.8e-168 561.3 0.0 2.3e-168 560.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 DAO PF01266.19 CCF33293.1 - 4.1e-09 35.8 1.9 8e-05 21.6 0.2 2.6 2 1 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF33293.1 - 1.4e-07 31.4 0.0 5.3e-07 29.5 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CCF33293.1 - 3.9e-06 25.9 0.9 5.5e-05 22.1 0.7 2.1 1 1 1 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.9 CCF33293.1 - 9.7e-06 25.5 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF33293.1 - 2.3e-05 23.0 0.6 3.3e-05 22.5 0.4 1.2 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.12 CCF33293.1 - 6.6e-05 22.1 0.2 0.0002 20.5 0.1 1.6 2 0 0 2 2 2 1 Thi4 family FAD_oxidored PF12831.2 CCF33293.1 - 0.00013 21.2 0.0 0.00016 20.9 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 CCF33293.1 - 0.00017 21.4 0.2 0.00077 19.2 0.1 1.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.14 CCF33293.1 - 0.00025 20.2 0.1 0.00063 18.8 0.1 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.22 CCF33293.1 - 0.00027 21.2 0.3 0.38 11.2 0.2 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF33293.1 - 0.00034 19.3 0.1 0.016 13.8 0.1 2.1 2 0 0 2 2 2 1 Tryptophan halogenase Lycopene_cycl PF05834.7 CCF33293.1 - 0.0012 17.9 0.2 0.0019 17.1 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.1 CCF33293.1 - 0.0035 17.4 0.0 0.0054 16.8 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CCF33293.1 - 0.02 13.7 0.1 0.027 13.3 0.1 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A K_oxygenase PF13434.1 CCF33293.1 - 0.14 11.0 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Cupin_1 PF00190.17 CCF33294.1 - 2.5e-32 111.3 0.0 7.1e-16 57.9 0.0 2.2 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.6 CCF33294.1 - 8.1e-23 79.7 0.5 1.7e-12 46.6 0.0 2.4 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.14 CCF33294.1 - 1.8e-05 24.4 0.1 0.016 14.9 0.0 2.5 2 0 0 2 2 2 2 AraC-like ligand binding domain Cupin_3 PF05899.7 CCF33294.1 - 2.3e-05 23.6 0.0 0.13 11.6 0.0 2.7 3 0 0 3 3 3 2 Protein of unknown function (DUF861) Cupin_6 PF12852.2 CCF33294.1 - 0.00022 20.8 0.0 0.28 10.8 0.0 2.2 2 0 0 2 2 2 2 Cupin 3-HAO PF06052.7 CCF33294.1 - 0.028 13.8 0.0 0.7 9.3 0.0 2.2 2 0 0 2 2 2 0 3-hydroxyanthranilic acid dioxygenase CENP-C_C PF11699.3 CCF33294.1 - 0.037 14.0 0.0 0.28 11.2 0.0 2.3 3 0 0 3 3 3 0 Mif2/CENP-C like Pec_lyase_C PF00544.14 CCF33295.1 - 0.00031 20.2 3.1 0.0005 19.5 2.1 1.3 1 0 0 1 1 1 1 Pectate lyase Zn_clus PF00172.13 CCF33297.1 - 0.0057 16.5 10.6 0.0095 15.8 7.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mito_carr PF00153.22 CCF33298.1 - 2.2e-73 242.0 2.5 4.7e-25 87.1 0.0 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein PX PF00787.19 CCF33299.1 - 3.4e-24 84.8 0.0 3.9e-24 84.6 0.0 1.0 1 0 0 1 1 1 1 PX domain DUF3987 PF13148.1 CCF33302.1 - 0.00034 19.2 2.0 0.00042 19.0 1.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3987) AIPR PF10592.4 CCF33302.1 - 0.046 13.0 1.8 0.056 12.7 1.2 1.0 1 0 0 1 1 1 0 AIPR protein A_deamin PF02137.13 CCF33302.1 - 0.046 13.0 1.0 0.058 12.6 0.7 1.1 1 0 0 1 1 1 0 Adenosine-deaminase (editase) domain V-ATPase_G PF03179.10 CCF33302.1 - 2.5 8.4 11.0 3.3 8.0 7.6 1.3 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Mto2_bdg PF12808.2 CCF33302.1 - 4.9 7.3 9.4 0.84 9.7 3.9 1.6 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Ribosomal_L2_C PF03947.13 CCF33303.1 - 1.1e-45 154.5 2.9 8.2e-45 151.7 2.0 2.4 1 1 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 CCF33303.1 - 6.6e-26 90.0 0.3 1.3e-25 89.1 0.2 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain zf-CCHC PF00098.18 CCF33305.1 - 4.6e-44 146.3 57.5 3.2e-08 33.1 1.6 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.1 CCF33305.1 - 9.4e-10 38.0 41.1 0.075 12.7 0.7 7.1 7 0 0 7 7 7 6 Zinc knuckle zf-CCHC_3 PF13917.1 CCF33305.1 - 1.4e-05 24.7 40.8 0.13 12.0 0.1 6.9 4 2 2 6 6 6 5 Zinc knuckle zf-CCHC_2 PF13696.1 CCF33305.1 - 0.089 12.3 0.3 0.089 12.3 0.2 7.1 4 2 3 7 7 7 0 Zinc knuckle zf-CCHC_6 PF15288.1 CCF33305.1 - 0.14 11.8 0.2 0.14 11.8 0.1 7.0 6 1 1 7 7 7 0 Zinc knuckle Peptidase_C2 PF00648.16 CCF33306.1 - 2.2e-56 191.0 5.6 1.7e-38 132.3 1.2 2.8 3 0 0 3 3 3 2 Calpain family cysteine protease DUF724 PF05266.9 CCF33306.1 - 0.71 9.4 10.0 1.7 8.2 6.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) FTA4 PF13093.1 CCF33307.1 - 6.2e-46 156.5 0.0 7.8e-46 156.1 0.0 1.1 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 SPR1 PF15356.1 CCF33307.1 - 1.4 9.3 5.3 0.99 9.7 0.2 2.3 2 0 0 2 2 2 0 Psoriasis susceptibility locus 2 TRAPP PF04051.11 CCF33308.1 - 7.8e-35 119.6 0.0 8.8e-35 119.4 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Apc13p PF05839.6 CCF33309.1 - 3.3e-31 107.0 0.2 5.8e-31 106.3 0.1 1.3 1 0 0 1 1 1 1 Apc13p protein Toxin_46 PF15526.1 CCF33309.1 - 0.016 15.3 0.9 0.026 14.6 0.6 1.3 1 0 0 1 1 1 0 Putative toxin 46 NDUF_B7 PF05676.8 CCF33312.1 - 0.18 11.2 2.8 0.16 11.4 0.9 1.7 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Hexapep PF00132.19 CCF33313.1 - 3.6e-09 35.7 11.0 3.5e-06 26.2 1.5 3.9 4 0 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 CCF33313.1 - 4.8e-06 26.0 12.8 0.003 17.0 0.8 3.0 2 1 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Complex1_51K PF01512.12 CCF33314.1 - 1.5e-47 161.1 0.0 2.3e-47 160.5 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.4 CCF33314.1 - 9.3e-19 66.3 0.4 9.3e-19 66.3 0.3 1.9 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.4 CCF33314.1 - 8.3e-09 35.2 0.0 2.1e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 SLBB domain PEX11 PF05648.9 CCF33315.1 - 4.8e-14 52.1 0.0 7.3e-09 35.2 0.0 3.1 2 2 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) REV PF00424.13 CCF33315.1 - 0.13 12.1 0.3 0.34 10.8 0.2 1.7 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) AAA_2 PF07724.9 CCF33316.1 - 5.6e-46 156.5 0.0 2.1e-44 151.4 0.0 3.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 CCF33316.1 - 3.8e-27 95.0 0.0 2.2e-14 53.7 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 CCF33316.1 - 4.5e-24 84.1 1.5 1.7e-23 82.2 0.4 2.7 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA_16 PF13191.1 CCF33316.1 - 1.1e-16 61.3 14.6 5.8e-07 29.6 0.0 6.7 3 2 3 6 6 6 2 AAA ATPase domain AAA_5 PF07728.9 CCF33316.1 - 2.1e-16 59.9 0.0 2.1e-10 40.4 0.0 3.2 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 CCF33316.1 - 1.6e-13 50.9 0.2 4.1e-05 23.7 0.0 4.3 2 2 1 3 3 3 2 AAA domain Clp_N PF02861.15 CCF33316.1 - 1.1e-09 38.0 2.2 3.2e-05 23.7 0.1 3.9 3 0 0 3 3 3 1 Clp amino terminal domain Sigma54_activat PF00158.21 CCF33316.1 - 5.4e-09 35.7 0.0 5.8e-06 25.8 0.0 2.7 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_17 PF13207.1 CCF33316.1 - 9.4e-09 36.1 3.5 0.01 16.6 0.0 4.2 2 2 0 2 2 2 2 AAA domain AAA_19 PF13245.1 CCF33316.1 - 1.5e-07 31.0 0.0 0.021 14.5 0.0 3.4 3 1 0 3 3 2 2 Part of AAA domain IstB_IS21 PF01695.12 CCF33316.1 - 6.5e-07 28.9 0.0 0.024 14.0 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.16 CCF33316.1 - 2.4e-06 26.8 0.0 0.1 11.7 0.0 3.7 2 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 CCF33316.1 - 3.9e-06 27.1 10.1 0.0087 16.3 0.0 4.9 5 1 0 5 5 5 2 AAA domain AAA_28 PF13521.1 CCF33316.1 - 1.8e-05 24.7 0.0 0.24 11.3 0.0 3.3 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 CCF33316.1 - 2e-05 24.4 0.1 0.18 11.7 0.0 3.4 2 1 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 CCF33316.1 - 3.4e-05 23.9 0.0 0.47 10.6 0.0 3.0 3 0 0 3 3 2 2 RNA helicase MobB PF03205.9 CCF33316.1 - 4.3e-05 23.2 0.0 0.33 10.6 0.0 2.9 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.1 CCF33316.1 - 5.5e-05 22.6 0.4 0.65 9.3 0.0 4.0 3 1 1 4 4 4 2 AAA domain T2SE PF00437.15 CCF33316.1 - 8.2e-05 21.6 0.5 0.01 14.7 0.0 2.9 3 0 0 3 3 2 1 Type II/IV secretion system protein AAA_3 PF07726.6 CCF33316.1 - 0.00011 21.8 0.0 0.69 9.5 0.0 3.8 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 CCF33316.1 - 0.00021 20.9 0.0 0.18 11.4 0.0 3.6 3 0 0 3 3 3 1 NACHT domain Arch_ATPase PF01637.13 CCF33316.1 - 0.00028 20.6 16.1 0.0078 15.9 0.2 5.9 4 2 1 5 5 4 1 Archaeal ATPase Zeta_toxin PF06414.7 CCF33316.1 - 0.00035 19.7 0.0 0.037 13.1 0.0 2.8 3 0 0 3 3 2 1 Zeta toxin DUF258 PF03193.11 CCF33316.1 - 0.00067 18.8 0.0 0.34 10.0 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 CCF33316.1 - 0.0008 19.7 0.1 1 9.6 0.0 3.2 3 0 0 3 3 2 1 ABC transporter AAA_24 PF13479.1 CCF33316.1 - 0.00083 18.9 0.2 1.7 8.2 0.0 3.4 4 0 0 4 4 3 1 AAA domain AAA_29 PF13555.1 CCF33316.1 - 0.0012 18.3 0.0 1 8.9 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain ResIII PF04851.10 CCF33316.1 - 0.0014 18.4 2.9 0.13 12.0 0.0 3.9 4 1 1 5 5 3 1 Type III restriction enzyme, res subunit KTI12 PF08433.5 CCF33316.1 - 0.0018 17.5 0.4 5.2 6.2 0.0 3.5 3 0 0 3 3 3 0 Chromatin associated protein KTI12 AAA_10 PF12846.2 CCF33316.1 - 0.0023 17.3 8.0 0.47 9.8 0.0 5.5 4 2 1 6 6 6 1 AAA-like domain NTPase_1 PF03266.10 CCF33316.1 - 0.0033 17.1 0.3 0.22 11.2 0.0 3.4 4 0 0 4 4 4 1 NTPase Torsin PF06309.6 CCF33316.1 - 0.0076 16.1 0.0 0.038 13.8 0.0 2.0 2 0 0 2 2 2 1 Torsin SRP54 PF00448.17 CCF33316.1 - 0.018 14.5 0.0 4 6.8 0.0 2.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain UPF0079 PF02367.12 CCF33316.1 - 0.021 14.4 0.0 8.2 6.0 0.0 2.9 3 0 0 3 3 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_21 PF13304.1 CCF33316.1 - 0.024 14.6 0.2 2.6 7.9 0.0 2.9 4 0 0 4 4 2 0 AAA domain AAA_23 PF13476.1 CCF33316.1 - 0.038 14.3 9.8 2.6 8.2 0.0 4.0 4 1 0 4 4 3 0 AAA domain ATP_bind_1 PF03029.12 CCF33316.1 - 0.061 12.8 0.0 7.4 6.0 0.0 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.4 CCF33316.1 - 0.078 12.4 0.0 6.9 6.1 0.0 2.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation V_ATPase_I PF01496.14 CCF33316.1 - 1.3 6.8 3.7 2.8 5.6 2.5 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Mhr1 PF12829.2 CCF33317.1 - 1.4e-29 101.7 0.1 2.2e-29 101.1 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination TPM PF04536.9 CCF33317.1 - 0.016 15.0 0.0 0.06 13.2 0.1 1.9 2 0 0 2 2 2 0 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase Dockerin_1 PF00404.13 CCF33319.1 - 0.22 11.3 1.0 0.43 10.3 0.7 1.5 1 0 0 1 1 1 0 Dockerin type I repeat TFIID-18kDa PF02269.11 CCF33320.1 - 6.7e-28 96.3 1.9 3.7e-27 93.9 0.1 2.6 3 0 0 3 3 3 1 Transcription initiation factor IID, 18kD subunit Myc_N PF01056.13 CCF33320.1 - 0.042 13.0 1.0 0.07 12.2 0.7 1.3 1 0 0 1 1 1 0 Myc amino-terminal region SCHIP-1 PF10148.4 CCF33320.1 - 0.052 12.9 0.1 0.13 11.6 0.1 1.6 1 0 0 1 1 1 0 Schwannomin-interacting protein 1 Ist1 PF03398.9 CCF33321.1 - 6.4e-67 224.0 2.3 8.3e-67 223.7 1.6 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway 7TMR-HDED PF07697.6 CCF33321.1 - 0.085 12.5 1.2 0.23 11.1 0.1 2.1 2 1 0 2 2 2 0 7TM-HD extracellular Glyco_hydro_81 PF03639.8 CCF33322.1 - 2.2e-173 577.9 0.4 2.8e-173 577.6 0.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 AMP-binding PF00501.23 CCF33323.1 - 7.3e-59 199.2 1.5 4.5e-31 107.6 0.0 4.8 3 2 0 3 3 3 3 AMP-binding enzyme YjbE PF11106.3 CCF33325.1 - 8.5 6.4 10.3 0.77 9.7 3.4 1.9 2 0 0 2 2 2 0 Exopolysaccharide production protein YjbE Transketolase_N PF00456.16 CCF33326.1 - 5.3e-141 469.2 0.0 9.1e-141 468.4 0.0 1.4 2 0 0 2 2 2 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 CCF33326.1 - 3.1e-44 150.5 0.0 5.2e-44 149.8 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 CCF33326.1 - 7.3e-14 51.7 0.0 1.6e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.1 CCF33326.1 - 2.9e-05 23.1 0.2 0.00073 18.5 0.1 2.0 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase tRNA-synt_1 PF00133.17 CCF33328.1 - 8.5e-162 539.2 0.0 1.1e-161 538.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 CCF33328.1 - 3.2e-09 36.7 0.0 5.5e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 CCF33328.1 - 8.6e-09 34.5 0.0 0.0034 16.1 0.0 2.7 3 0 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 CCF33328.1 - 0.015 14.3 0.0 0.028 13.5 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain tRNA-synt_1 PF00133.17 CCF33329.1 - 3.8e-51 173.8 0.0 4.5e-51 173.5 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 CCF33329.1 - 3.3e-07 29.3 0.0 4.2e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) Mo25 PF08569.6 CCF33330.1 - 8.4e-126 419.5 0.0 9.4e-126 419.3 0.0 1.0 1 0 0 1 1 1 1 Mo25-like DNA_topoisoIV PF00521.15 CCF33330.1 - 0.043 12.6 0.1 0.086 11.6 0.0 1.4 2 0 0 2 2 2 0 DNA gyrase/topoisomerase IV, subunit A RepA_N PF06970.6 CCF33330.1 - 0.08 12.7 0.2 0.21 11.3 0.1 1.7 1 0 0 1 1 1 0 Replication initiator protein A (RepA) N-terminus adh_short PF00106.20 CCF33331.1 - 9.4e-24 84.2 0.0 1.4e-23 83.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF33331.1 - 3.9e-10 39.9 0.0 5e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF33331.1 - 1.4e-06 28.0 0.1 2.9e-06 27.0 0.0 1.5 2 0 0 2 2 2 1 KR domain 3HCDH_N PF02737.13 CCF33331.1 - 0.00015 21.4 0.5 0.00035 20.2 0.3 1.6 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.16 CCF33331.1 - 0.0017 17.8 0.1 0.0052 16.2 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.12 CCF33331.1 - 0.0026 18.1 0.2 0.0059 16.9 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Pyr_redox PF00070.22 CCF33331.1 - 0.0049 17.2 0.9 0.013 15.9 0.6 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.13 CCF33331.1 - 0.0085 16.0 0.4 0.022 14.7 0.1 1.7 2 0 0 2 2 2 1 TrkA-N domain 2-Hacid_dh_C PF02826.14 CCF33331.1 - 0.0089 15.1 0.0 0.024 13.8 0.1 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 CCF33331.1 - 0.013 14.4 0.2 0.023 13.7 0.1 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NAD_binding_10 PF13460.1 CCF33331.1 - 0.037 14.0 0.2 0.097 12.6 0.1 1.7 2 0 0 2 2 2 0 NADH(P)-binding Shikimate_DH PF01488.15 CCF33331.1 - 0.093 12.8 0.1 0.33 11.0 0.1 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_8 PF13450.1 CCF33331.1 - 0.1 12.6 0.3 0.23 11.4 0.2 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain SWIB PF02201.13 CCF33332.1 - 2.6e-12 46.2 0.0 5.9e-12 45.1 0.0 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain DNA_pol_E_B PF04042.11 CCF33332.1 - 0.026 13.7 0.1 0.039 13.1 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B Csm1 PF12539.3 CCF33333.1 - 6.9e-26 90.5 0.0 1.6e-25 89.4 0.0 1.6 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 TPR_MLP1_2 PF07926.7 CCF33333.1 - 0.0066 16.1 3.0 0.0066 16.1 2.1 3.3 5 0 0 5 5 4 1 TPR/MLP1/MLP2-like protein Herpes_UL25 PF01499.11 CCF33333.1 - 0.053 11.8 5.6 0.11 10.8 3.9 1.5 1 0 0 1 1 1 0 Herpesvirus UL25 family Prefoldin PF02996.12 CCF33333.1 - 0.056 13.0 3.8 0.23 11.0 2.6 2.1 1 1 0 1 1 1 0 Prefoldin subunit Reo_sigmaC PF04582.7 CCF33333.1 - 0.099 11.8 3.9 0.31 10.1 2.6 1.5 1 1 0 1 1 1 0 Reovirus sigma C capsid protein Macoilin PF09726.4 CCF33333.1 - 0.2 9.8 23.6 0.28 9.4 16.4 1.1 1 0 0 1 1 1 0 Transmembrane protein Spc7 PF08317.6 CCF33333.1 - 0.3 9.6 6.2 0.58 8.7 4.3 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein GAS PF13851.1 CCF33333.1 - 0.31 10.2 8.3 0.18 10.9 2.2 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding IncA PF04156.9 CCF33333.1 - 0.41 10.2 9.2 0.76 9.3 6.3 1.6 1 1 0 1 1 1 0 IncA protein FliJ PF02050.11 CCF33333.1 - 0.42 10.6 9.9 0.24 11.4 5.0 1.9 2 0 0 2 2 2 0 Flagellar FliJ protein Spc24 PF08286.6 CCF33333.1 - 0.72 9.5 4.9 1.5 8.4 0.4 2.8 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Phage_lysis PF03245.8 CCF33333.1 - 0.85 9.6 14.1 4.7 7.2 9.8 2.3 1 1 0 1 1 1 0 Bacteriophage Rz lysis protein TMPIT PF07851.8 CCF33333.1 - 4.9 6.1 7.9 0.98 8.4 2.0 1.9 2 0 0 2 2 2 0 TMPIT-like protein PigN PF04987.9 CCF33334.1 - 1.1e-160 535.0 27.0 1.1e-160 535.0 18.7 1.5 2 0 0 2 2 2 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.17 CCF33334.1 - 6e-11 42.2 0.4 1.9e-09 37.3 0.3 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 CCF33334.1 - 3.2e-09 36.3 0.2 5.2e-09 35.7 0.1 1.3 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.13 CCF33334.1 - 0.00066 19.1 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily SPC12 PF06645.8 CCF33334.1 - 0.067 13.0 1.2 0.43 10.4 0.9 2.5 1 0 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) CBS PF00571.23 CCF33335.1 - 6.5e-41 137.8 5.4 1.7e-10 40.4 0.0 4.7 4 0 0 4 4 4 4 CBS domain PB1 PF00564.19 CCF33335.1 - 1.3e-07 31.1 0.0 4.4e-07 29.4 0.0 2.0 2 0 0 2 2 2 1 PB1 domain zf-C4H2 PF10146.4 CCF33335.1 - 0.061 13.3 1.2 0.73 9.8 0.0 2.8 3 0 0 3 3 3 0 Zinc finger-containing protein Ribosomal_S2 PF00318.15 CCF33336.1 - 1.1e-49 168.5 0.0 2e-49 167.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S2 DUF1330 PF07045.6 CCF33336.1 - 0.053 13.3 0.1 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1330) FA_hydroxylase PF04116.8 CCF33337.1 - 0.001 19.4 1.7 0.0017 18.7 1.2 1.3 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily AA_permease PF00324.16 CCF33338.1 - 1.4e-125 419.4 34.2 1.7e-125 419.0 23.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF33338.1 - 4e-42 144.2 37.4 5e-42 143.9 25.9 1.1 1 0 0 1 1 1 1 Amino acid permease Amidase PF01425.16 CCF33339.1 - 6.6e-70 236.1 0.0 1.2e-68 232.0 0.0 2.0 1 1 0 1 1 1 1 Amidase HSP70 PF00012.15 CCF33341.1 - 1e-10 40.2 0.2 7e-10 37.4 0.0 1.9 2 0 0 2 2 2 1 Hsp70 protein DUF2439 PF10382.4 CCF33341.1 - 0.039 14.1 0.1 1.5 9.0 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2439) Aminotran_5 PF00266.14 CCF33343.1 - 1.3e-09 37.2 0.0 1.4e-08 33.9 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 CCF33343.1 - 0.008 15.2 0.0 0.012 14.6 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 CCF33343.1 - 0.085 11.7 0.0 0.56 9.0 0.0 2.0 2 0 0 2 2 2 0 Aminotransferase class I and II PLDc_N PF13396.1 CCF33344.1 - 1.3e-11 43.9 4.2 2.1e-11 43.3 2.9 1.3 1 0 0 1 1 1 1 Phospholipase_D-nuclease N-terminal Pox_A14 PF05767.7 CCF33344.1 - 0.027 14.4 0.2 0.039 13.8 0.1 1.3 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 DUF3309 PF11752.3 CCF33344.1 - 0.037 13.8 0.7 0.037 13.8 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3309) DUF2207 PF09972.4 CCF33344.1 - 0.05 12.1 1.2 0.049 12.2 0.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EamA PF00892.15 CCF33344.1 - 0.056 13.4 0.6 0.056 13.4 0.4 1.6 2 0 0 2 2 2 0 EamA-like transporter family FixQ PF05545.6 CCF33344.1 - 0.086 12.5 0.8 0.086 12.5 0.6 2.1 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ SPC25 PF06703.6 CCF33344.1 - 0.33 10.5 2.1 1.4 8.4 0.3 2.0 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF3951 PF13131.1 CCF33344.1 - 0.48 10.2 0.0 0.48 10.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3951) EmrE PF13536.1 CCF33344.1 - 0.63 10.2 4.8 1.2 9.4 3.4 1.4 1 1 0 1 1 1 0 Multidrug resistance efflux transporter Peptidase_S8 PF00082.17 CCF33346.1 - 1.3e-16 60.6 0.3 5.7e-16 58.5 0.1 1.8 2 0 0 2 2 2 1 Subtilase family DUF1205 PF06722.7 CCF33346.1 - 0.013 15.7 0.0 0.028 14.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1205) LIM PF00412.17 CCF33347.1 - 2.1e-15 56.5 17.8 1e-09 38.3 1.2 2.3 2 0 0 2 2 2 2 LIM domain Zn-ribbon_8 PF09723.5 CCF33347.1 - 0.036 14.0 18.1 0.12 12.3 1.0 4.3 4 0 0 4 4 4 0 Zinc ribbon domain zinc_ribbon_2 PF13240.1 CCF33347.1 - 2 7.9 0.0 2 7.9 0.0 5.0 5 1 1 6 6 6 0 zinc-ribbon domain GalP_UDP_transf PF01087.17 CCF33349.1 - 1.2e-59 201.4 0.1 1.6e-59 201.0 0.1 1.1 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.12 CCF33349.1 - 0.0024 17.4 1.1 0.012 15.1 0.2 2.1 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain SWIRM PF04433.12 CCF33350.1 - 3.3e-13 49.5 0.0 8.9e-13 48.1 0.0 1.8 1 0 0 1 1 1 1 SWIRM domain ZZ PF00569.12 CCF33350.1 - 1.9e-11 43.3 7.5 3.6e-11 42.4 5.2 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.26 CCF33350.1 - 4.9e-07 29.6 0.3 2.5e-06 27.4 0.0 2.3 3 0 0 3 3 3 1 Myb-like DNA-binding domain Mating_C PF12737.2 CCF33351.1 - 0.17 10.7 3.3 0.2 10.4 2.3 1.1 1 0 0 1 1 1 0 C-terminal domain of homeodomain 1 COesterase PF00135.23 CCF33352.1 - 9.3e-83 278.7 0.0 1.1e-82 278.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF33352.1 - 0.031 13.8 0.0 0.11 12.0 0.0 2.0 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF3237 PF11578.3 CCF33353.1 - 1.4e-26 92.5 0.1 2.2e-26 91.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) Tyrosinase PF00264.15 CCF33354.1 - 2.9e-51 174.7 2.5 2.9e-51 174.7 1.8 1.7 2 0 0 2 2 2 1 Common central domain of tyrosinase Tannase PF07519.6 CCF33356.1 - 3.4e-33 115.0 4.8 4.3e-33 114.7 3.3 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Zn_clus PF00172.13 CCF33357.1 - 9.9e-08 31.7 10.9 9.9e-08 31.7 7.6 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF33357.1 - 0.0052 15.4 0.1 0.042 12.4 0.0 2.0 1 1 1 2 2 2 1 Fungal specific transcription factor domain Glycos_transf_1 PF00534.15 CCF33359.1 - 5.1e-23 81.3 0.0 1.1e-22 80.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 CCF33359.1 - 6.4e-10 39.3 0.0 1.7e-09 37.9 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 CCF33359.1 - 0.0006 20.0 0.0 0.0017 18.5 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Haem_bd PF14376.1 CCF33359.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Haem-binding domain RhoGEF PF00621.15 CCF33361.1 - 1.9e-34 119.1 0.1 5e-34 117.7 0.0 1.8 2 0 0 2 2 2 1 RhoGEF domain BAR PF03114.13 CCF33361.1 - 3.1e-12 46.5 0.2 7.5e-12 45.2 0.1 1.7 1 0 0 1 1 1 1 BAR domain Seryl_tRNA_N PF02403.17 CCF33361.1 - 0.36 10.8 4.0 8.7 6.4 0.3 2.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Velvet PF11754.3 CCF33362.1 - 2.6e-74 249.2 0.1 6.6e-74 247.9 0.1 1.6 1 1 0 1 1 1 1 Velvet factor Mem_trans PF03547.13 CCF33364.1 - 0.54 8.5 1.4 1 7.5 1.0 1.6 1 0 0 1 1 1 0 Membrane transport protein LMBR1 PF04791.11 CCF33364.1 - 1.1 7.7 1.9 1.6 7.1 1.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein W2 PF02020.13 CCF33365.1 - 1.8e-25 88.6 0.6 1.8e-25 88.6 0.4 2.1 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Cu-oxidase_3 PF07732.10 CCF33366.1 - 1.3e-37 128.0 2.2 1.3e-37 128.0 1.5 2.3 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 CCF33366.1 - 4.6e-37 126.6 0.9 4.6e-37 126.6 0.6 3.1 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 CCF33366.1 - 3.7e-33 114.6 3.4 5.1e-32 110.9 0.7 2.6 2 0 0 2 2 2 1 Multicopper oxidase ADIP PF11559.3 CCF33367.1 - 0.38 10.6 14.4 0.77 9.6 10.0 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Phlebovirus_NSM PF07246.6 CCF33367.1 - 4.5 6.3 6.4 6.5 5.8 4.5 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M DUF4200 PF13863.1 CCF33367.1 - 5.2 7.0 18.9 0.34 10.8 9.8 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) TBCC PF07986.7 CCF33368.1 - 4.3e-32 110.0 0.1 6.6e-32 109.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C Med9 PF07544.8 CCF33369.1 - 3.7e-24 84.2 0.2 1.1e-23 82.7 0.2 1.6 2 0 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 Fib_alpha PF08702.5 CCF33369.1 - 0.0037 17.3 1.1 0.0065 16.6 0.8 1.3 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family IncA PF04156.9 CCF33369.1 - 0.005 16.4 1.3 0.0085 15.7 0.9 1.4 1 0 0 1 1 1 1 IncA protein Med21 PF11221.3 CCF33369.1 - 0.01 15.7 2.2 0.014 15.3 1.5 1.3 1 1 0 1 1 1 0 Subunit 21 of Mediator complex Golgin_A5 PF09787.4 CCF33369.1 - 0.011 14.2 0.0 0.014 13.9 0.0 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 HemX PF04375.9 CCF33369.1 - 0.028 13.0 0.1 0.031 12.8 0.0 1.2 1 0 0 1 1 1 0 HemX Phage_GP20 PF06810.6 CCF33369.1 - 0.033 13.6 0.6 0.048 13.1 0.4 1.1 1 0 0 1 1 1 0 Phage minor structural protein GP20 Cob_adeno_trans PF01923.13 CCF33369.1 - 0.039 13.7 0.1 0.064 13.0 0.1 1.3 1 0 0 1 1 1 0 Cobalamin adenosyltransferase BLOC1_2 PF10046.4 CCF33369.1 - 0.055 13.6 0.3 0.087 12.9 0.2 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMF_DNA_bd PF12329.3 CCF33369.1 - 0.12 12.1 1.9 0.18 11.5 0.7 1.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Atg14 PF10186.4 CCF33369.1 - 0.13 11.1 2.3 0.18 10.6 1.6 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 NPV_P10 PF05531.7 CCF33369.1 - 0.15 12.3 0.3 0.76 10.0 0.1 1.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.7 CCF33369.1 - 4.8 7.6 8.3 3.7 7.9 2.5 2.6 2 1 1 3 3 3 0 SlyX iPGM_N PF06415.8 CCF33370.1 - 1.3e-68 230.7 0.0 1.8e-68 230.2 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.13 CCF33370.1 - 2.6e-65 220.3 0.1 3.1e-65 220.0 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.18 CCF33370.1 - 1.8e-07 30.6 0.0 1.8e-06 27.3 0.0 2.0 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.17 CCF33370.1 - 3.6e-07 29.8 0.0 7.8e-07 28.7 0.0 1.5 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase AP_endonuc_2 PF01261.19 CCF33370.1 - 0.019 14.2 0.0 0.042 13.1 0.0 1.5 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Glyco_hydro_76 PF03663.9 CCF33371.1 - 3.2e-46 158.3 14.7 2.3e-45 155.6 10.2 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.8 CCF33371.1 - 2.8e-06 26.6 2.6 0.017 14.2 0.1 2.8 2 1 1 3 3 3 2 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.8 CCF33371.1 - 0.0034 16.7 0.1 0.025 13.8 0.0 2.3 2 1 1 3 3 3 1 D-glucuronyl C5-epimerase C-terminus GlcNAc_2-epim PF07221.6 CCF33371.1 - 0.0035 16.4 0.0 0.0076 15.2 0.0 1.5 1 0 0 1 1 1 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) DUF1680 PF07944.7 CCF33371.1 - 0.014 13.7 0.1 0.66 8.1 0.1 2.2 1 1 1 2 2 2 0 Putative glycosyl hydrolase of unknown function (DUF1680) CBM-like PF14683.1 CCF33373.1 - 8.2e-11 41.8 0.1 1.9e-10 40.6 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.1 CCF33373.1 - 1.9e-10 40.7 0.3 6.1e-10 39.0 0.2 1.9 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.1 CCF33373.1 - 0.003 17.5 0.2 0.0086 16.1 0.1 1.7 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain Phosphodiest PF01663.17 CCF33374.1 - 2.4e-14 53.4 1.9 2.3e-13 50.1 1.4 2.0 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.13 CCF33374.1 - 0.00058 19.3 0.2 0.0011 18.3 0.1 1.4 1 1 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.18 CCF33374.1 - 0.0096 15.1 0.0 0.018 14.2 0.0 1.4 1 0 0 1 1 1 1 Sulfatase DUF229 PF02995.12 CCF33374.1 - 0.16 10.3 0.1 0.24 9.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) DUF3353 PF11833.3 CCF33374.1 - 0.44 9.9 4.3 0.64 9.4 2.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3353) DUF2423 PF10338.4 CCF33375.1 - 5.1e-16 58.3 3.0 5.1e-16 58.3 2.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) HMG14_17 PF01101.13 CCF33375.1 - 0.39 11.4 12.7 5.9 7.6 8.2 2.4 1 1 1 2 2 2 0 HMG14 and HMG17 CDC45 PF02724.9 CCF33375.1 - 1.5 6.7 7.1 1.6 6.6 4.9 1.1 1 0 0 1 1 1 0 CDC45-like protein PINIT PF14324.1 CCF33376.1 - 2.1e-34 118.6 0.1 4.2e-34 117.6 0.1 1.5 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.15 CCF33376.1 - 3.7e-22 77.5 5.8 9.5e-22 76.2 4.0 1.7 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.3 CCF33376.1 - 8.9e-06 25.1 1.6 2e-05 24.0 1.1 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.1 CCF33376.1 - 0.055 13.3 5.6 0.1 12.4 3.9 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING SAP PF02037.22 CCF33376.1 - 0.058 12.9 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 SAP domain zf-Sec23_Sec24 PF04810.10 CCF33376.1 - 0.073 12.6 0.0 0.073 12.6 0.0 2.1 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger zf-RING_5 PF14634.1 CCF33376.1 - 0.37 10.5 3.2 0.68 9.7 2.2 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Fungal_trans PF04082.13 CCF33377.1 - 2.1e-32 112.0 0.0 4e-32 111.1 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF33377.1 - 8.6e-11 41.5 13.6 1.6e-10 40.7 9.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fer2 PF00111.22 CCF33377.1 - 0.055 13.2 2.8 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain FimP PF09766.4 CCF33377.1 - 0.63 9.0 11.7 1.2 8.1 8.1 1.3 1 0 0 1 1 1 0 Fms-interacting protein Suf PF05843.9 CCF33377.1 - 0.8 9.3 8.4 0.4 10.3 4.1 1.7 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Activator_LAG-3 PF11498.3 CCF33377.1 - 2.1 7.0 34.4 3.5 6.2 23.9 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF4175 PF13779.1 CCF33377.1 - 7.7 4.0 27.7 17 2.9 19.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Tautomerase_3 PF14832.1 CCF33378.1 - 2.9e-17 62.9 0.1 3.2e-17 62.8 0.0 1.0 1 0 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme MHC_II_alpha PF00993.15 CCF33378.1 - 0.045 13.3 0.0 0.049 13.2 0.0 1.1 1 0 0 1 1 1 0 Class II histocompatibility antigen, alpha domain SelR PF01641.13 CCF33378.1 - 0.13 11.9 0.1 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 SelR domain Epimerase PF01370.16 CCF33379.1 - 1.7e-13 50.5 0.1 1.1e-08 34.7 0.0 2.4 1 1 1 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF33379.1 - 3.7e-12 46.6 0.0 3.1e-10 40.3 0.0 2.2 1 1 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 CCF33379.1 - 2e-10 39.8 0.0 3.2e-07 29.3 0.0 2.1 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 CCF33379.1 - 1.2e-08 34.2 0.0 4.3e-05 22.5 0.1 2.1 1 1 0 2 2 2 2 Male sterility protein NmrA PF05368.8 CCF33379.1 - 3.1e-07 29.8 0.0 7.4e-07 28.6 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.10 CCF33379.1 - 3.1e-05 23.0 0.0 4.7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 CCF33379.1 - 0.0003 20.7 0.0 0.00055 19.8 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase CFEM PF05730.6 CCF33380.1 - 1.9e-10 40.4 7.5 2.4e-10 40.0 5.2 1.2 1 0 0 1 1 1 1 CFEM domain Gamma-thionin PF00304.15 CCF33380.1 - 0.011 15.7 1.2 0.011 15.7 0.9 1.6 2 0 0 2 2 2 0 Gamma-thionin family TIL PF01826.12 CCF33380.1 - 0.62 10.2 7.1 0.89 9.7 4.9 1.3 1 0 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain Abi PF02517.11 CCF33381.1 - 1.1 9.4 7.8 1.8 8.7 5.4 1.5 1 1 0 1 1 1 0 CAAX protease self-immunity LtrA PF06772.6 CCF33383.1 - 7.7e-17 61.2 12.7 1e-16 60.8 8.8 1.1 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) COesterase PF00135.23 CCF33384.1 - 7.4e-97 325.2 0.2 3e-79 267.1 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF33384.1 - 4.1e-06 26.5 0.0 7.9e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF33384.1 - 0.03 14.0 0.0 0.051 13.3 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF33384.1 - 0.033 13.4 0.1 0.057 12.6 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Chromo PF00385.19 CCF33385.1 - 1.4e-12 47.0 1.8 1.4e-12 47.0 1.2 2.1 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.14 CCF33385.1 - 1.4e-11 44.0 0.1 5.8e-11 42.0 0.0 1.9 2 0 0 2 2 2 1 Chromo shadow domain AT_hook PF02178.14 CCF33385.1 - 1.5 8.7 5.2 0.21 11.3 0.4 2.1 2 0 0 2 2 2 0 AT hook motif DNA_pol_phi PF04931.8 CCF33385.1 - 3.3 5.3 14.6 4.5 4.9 10.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi TRP PF06011.7 CCF33386.1 - 0.057 11.9 0.7 0.064 11.8 0.5 1.0 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF4577 PF15145.1 CCF33386.1 - 0.062 13.2 0.1 0.062 13.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) DUF4307 PF14155.1 CCF33386.1 - 0.15 11.8 0.7 0.19 11.4 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) DUF3678 PF12435.3 CCF33386.1 - 0.47 10.0 3.3 0.81 9.2 2.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3678) DUF1206 PF06724.6 CCF33386.1 - 1.4 8.7 5.6 0.65 9.7 2.2 1.7 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1206) 2Fe-2S_thioredx PF01257.14 CCF33389.1 - 3e-58 195.5 0.0 3.7e-58 195.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin Kelch_3 PF13415.1 CCF33390.1 - 4.1e-26 90.4 18.6 1e-07 31.8 0.2 8.2 9 1 0 9 9 9 5 Galactose oxidase, central domain Kelch_4 PF13418.1 CCF33390.1 - 6.9e-21 73.7 12.4 3e-06 26.9 0.1 6.8 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.1 CCF33390.1 - 3.4e-18 64.9 0.3 4.9e-05 23.3 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_5 PF13854.1 CCF33390.1 - 2.6e-17 62.3 5.5 0.00022 21.1 0.0 6.7 7 0 0 7 7 7 3 Kelch motif Kelch_1 PF01344.20 CCF33390.1 - 1.5e-13 49.9 3.4 8e-05 22.1 0.0 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 CCF33390.1 - 4.4e-13 48.4 3.5 5e-06 26.0 0.1 5.3 5 0 0 5 5 5 3 Kelch motif UQ_con PF00179.21 CCF33392.1 - 1.2e-30 105.8 0.0 1.6e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CCF33392.1 - 0.0018 18.0 0.0 0.0027 17.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 CCF33392.1 - 0.06 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 UEV domain RWD PF05773.17 CCF33392.1 - 0.098 12.5 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 RWD domain Anp1 PF03452.9 CCF33393.1 - 1.8e-110 368.3 0.0 2.3e-110 368.0 0.0 1.0 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.21 CCF33393.1 - 0.038 13.6 0.0 0.07 12.8 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 zf-RING_2 PF13639.1 CCF33394.1 - 0.00019 21.1 9.7 0.00037 20.2 6.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 CCF33394.1 - 0.0019 18.2 9.7 0.0042 17.0 6.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF33394.1 - 0.0095 15.6 9.8 0.02 14.6 6.8 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 CCF33394.1 - 0.044 13.5 4.6 0.087 12.5 2.5 2.0 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4 PF00097.20 CCF33394.1 - 0.074 12.7 10.4 0.15 11.7 7.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CcdA PF07362.7 CCF33394.1 - 0.13 12.1 0.1 0.23 11.3 0.1 1.4 1 0 0 1 1 1 0 Post-segregation antitoxin CcdA FYVE PF01363.16 CCF33394.1 - 0.15 11.9 5.9 0.41 10.5 4.1 1.7 1 0 0 1 1 1 0 FYVE zinc finger zf-C3HC4_4 PF15227.1 CCF33394.1 - 0.43 10.5 8.7 1.5 8.7 6.1 2.0 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING CorA PF01544.13 CCF33396.1 - 2e-14 53.2 0.1 3.2e-14 52.6 0.1 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein K_channel_TID PF07941.6 CCF33396.1 - 0.15 12.3 0.1 0.3 11.3 0.1 1.4 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Polysacc_synt_C PF14667.1 CCF33396.1 - 0.16 11.7 1.6 0.25 11.1 0.1 1.8 1 1 1 2 2 2 0 Polysaccharide biosynthesis C-terminal domain Pkinase PF00069.20 CCF33397.1 - 3.1e-56 190.4 0.0 4.4e-56 189.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF33397.1 - 3.4e-26 91.8 0.2 1.6e-25 89.6 0.1 2.0 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF33397.1 - 0.022 13.7 0.0 0.036 13.0 0.0 1.2 1 0 0 1 1 1 0 Kinase-like DUF4112 PF13430.1 CCF33398.1 - 7.5e-34 115.8 0.2 9.9e-34 115.4 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) DUF2763 PF10961.3 CCF33398.1 - 3 8.2 5.8 11 6.4 0.1 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2763) DCP2 PF05026.8 CCF33399.1 - 4.6e-37 125.7 0.6 1.2e-36 124.4 0.4 1.8 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.23 CCF33399.1 - 2.6e-16 59.4 0.0 5.5e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain DUF3863 PF12979.2 CCF33399.1 - 0.33 9.4 0.0 0.54 8.8 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3863) DUF1100 PF06500.6 CCF33400.1 - 2.2e-11 43.0 0.0 2.7e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Abhydrolase_5 PF12695.2 CCF33400.1 - 5e-09 36.0 0.0 7.9e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF33400.1 - 5.7e-09 36.1 0.2 1.3e-08 35.0 0.1 1.7 1 1 1 2 2 2 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.13 CCF33400.1 - 2.6e-06 27.0 0.0 4.3e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.15 CCF33400.1 - 2.3e-05 23.9 0.0 0.00029 20.3 0.0 2.1 1 1 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.16 CCF33400.1 - 9.1e-05 21.7 0.0 0.00017 20.8 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase_phd PF10503.4 CCF33400.1 - 0.014 14.6 0.2 0.036 13.2 0.0 1.7 2 0 0 2 2 2 0 Esterase PHB depolymerase Acetyltransf_1 PF00583.19 CCF33401.1 - 2.3e-10 40.3 0.0 3.6e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF33401.1 - 2.1e-09 37.4 0.1 2.9e-09 36.9 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 CCF33401.1 - 0.052 13.6 0.0 0.062 13.4 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 CCF33401.1 - 0.056 13.2 0.0 0.077 12.8 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AstA PF04958.7 CCF33401.1 - 0.12 10.8 0.0 0.17 10.3 0.0 1.2 1 0 0 1 1 1 0 Arginine N-succinyltransferase beta subunit p450 PF00067.17 CCF33403.1 - 4.5e-13 48.5 0.0 5.5e-13 48.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.11 CCF33404.1 - 4.4e-27 94.7 15.6 5e-27 94.5 10.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF33404.1 - 5e-11 41.8 9.1 6.3e-11 41.5 6.3 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter RabGAP-TBC PF00566.13 CCF33405.1 - 8.2e-21 74.4 0.0 2.1e-20 73.1 0.0 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Vps52 PF04129.7 CCF33406.1 - 1.5e-115 386.6 0.1 2e-115 386.2 0.1 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.4 CCF33406.1 - 6.6e-06 24.5 5.3 5.9e-05 21.4 3.6 2.0 1 1 0 1 1 1 1 Exocyst complex component Sec3 DUF869 PF05911.6 CCF33406.1 - 0.012 13.8 0.3 0.018 13.3 0.2 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) Cast PF10174.4 CCF33406.1 - 0.02 12.9 0.2 0.045 11.8 0.1 1.6 2 0 0 2 2 2 0 RIM-binding protein of the cytomatrix active zone IncA PF04156.9 CCF33406.1 - 0.027 14.0 1.7 0.041 13.4 0.1 2.0 2 0 0 2 2 2 0 IncA protein Mer2 PF09074.5 CCF33406.1 - 0.042 13.7 0.4 0.16 11.8 0.0 2.1 2 0 0 2 2 2 0 Mer2 CENP-F_leu_zip PF10473.4 CCF33406.1 - 0.15 11.8 2.4 0.11 12.3 0.3 1.8 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Filament PF00038.16 CCF33406.1 - 0.23 10.9 4.3 0.18 11.2 0.1 2.1 2 0 0 2 2 2 0 Intermediate filament protein Lyase_1 PF00206.15 CCF33407.1 - 1.8e-18 66.8 0.0 3.8e-18 65.7 0.0 1.5 2 0 0 2 2 2 1 Lyase ADSL_C PF10397.4 CCF33407.1 - 1e-14 54.2 0.0 2.9e-14 52.8 0.0 1.8 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus DUF1748 PF08520.5 CCF33408.1 - 0.14 11.8 0.0 0.57 9.8 0.0 1.9 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1748) PHO4 PF01384.15 CCF33409.1 - 2.6e-110 368.1 20.5 3.2e-110 367.8 14.2 1.1 1 0 0 1 1 1 1 Phosphate transporter family adh_short PF00106.20 CCF33411.1 - 4.6e-10 39.6 0.1 5.8e-10 39.3 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF33411.1 - 4.1e-06 26.7 0.0 5e-06 26.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NmrA PF05368.8 CCF33411.1 - 5.6e-06 25.7 0.4 9.7e-06 25.0 0.3 1.3 1 0 0 1 1 1 1 NmrA-like family KR PF08659.5 CCF33411.1 - 1.2e-05 25.0 0.0 1.5e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF33411.1 - 0.0002 21.4 0.7 0.00091 19.2 0.5 2.0 1 1 0 1 1 1 1 NADH(P)-binding Eno-Rase_NADH_b PF12242.3 CCF33411.1 - 0.008 15.9 0.6 0.017 14.9 0.4 1.5 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase PALP PF00291.20 CCF33411.1 - 0.033 13.4 0.0 0.05 12.8 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme DapB_N PF01113.15 CCF33411.1 - 0.034 14.0 0.3 0.17 11.8 0.1 1.9 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Vps4_C PF09336.5 CCF33412.1 - 2.1e-09 37.0 0.0 6.3e-07 29.1 0.0 2.3 2 0 0 2 2 2 2 Vps4 C terminal oligomerisation domain Ribosomal_S17 PF00366.15 CCF33413.1 - 3e-07 30.3 0.2 5.2e-07 29.6 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 GTP_EFTU_D2 PF03144.20 CCF33413.1 - 0.058 13.5 0.1 0.79 9.8 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu domain 2 EMG1 PF03587.9 CCF33414.1 - 3e-78 261.7 0.0 3.5e-78 261.5 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase AMP-binding PF00501.23 CCF33415.1 - 7.3e-75 251.9 0.0 9.9e-75 251.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme KH_1 PF00013.24 CCF33416.1 - 9.8e-87 284.5 32.3 8.3e-13 47.7 0.1 13.4 14 1 0 14 14 14 10 KH domain KH_3 PF13014.1 CCF33416.1 - 1.6e-57 190.3 28.6 1.6e-10 40.3 0.5 12.3 13 0 0 13 13 13 8 KH domain KH_2 PF07650.12 CCF33416.1 - 1.7e-10 40.2 25.1 0.028 13.9 0.3 7.3 6 1 0 7 7 7 4 KH domain SLS PF14611.1 CCF33416.1 - 1.4e-08 34.4 10.7 0.1 11.9 0.1 6.4 4 1 2 7 7 7 3 Mitochondrial inner-membrane-bound regulator KH_4 PF13083.1 CCF33416.1 - 0.0035 16.9 6.1 0.14 11.8 0.1 5.2 5 0 0 5 5 5 1 KH domain DUF4055 PF13264.1 CCF33416.1 - 0.054 13.5 0.0 0.2 11.7 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4055) Fungal_trans PF04082.13 CCF33417.1 - 5.3e-22 77.9 0.3 5.3e-22 77.9 0.2 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF33417.1 - 4.6e-05 23.2 8.3 9.5e-05 22.2 5.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF416 PF04222.7 CCF33417.1 - 0.071 12.2 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF416) Daxx PF03344.10 CCF33418.1 - 1.7 7.0 7.8 2 6.7 5.4 1.2 1 0 0 1 1 1 0 Daxx Family Macoilin PF09726.4 CCF33418.1 - 5.6 5.1 12.8 6.6 4.8 8.8 1.3 1 0 0 1 1 1 0 Transmembrane protein TrkH PF02386.11 CCF33419.1 - 1.1e-27 96.5 5.1 2.9e-23 82.0 1.2 2.1 2 0 0 2 2 2 2 Cation transport protein TFCD_C PF12612.3 CCF33420.1 - 5.5e-30 104.2 0.5 2.3e-29 102.1 0.4 2.1 1 1 0 1 1 1 1 Tubulin folding cofactor D C terminal HEAT PF02985.17 CCF33420.1 - 0.008 16.1 5.2 1.8 8.8 0.0 5.6 6 0 0 6 6 6 1 HEAT repeat TraE PF05309.6 CCF33422.1 - 1.1 8.3 0.1 1.8 7.7 0.1 1.2 1 0 0 1 1 1 0 TraE protein Peptidase_C12 PF01088.16 CCF33424.1 - 2.7e-56 190.1 0.0 5.1e-56 189.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Transglut_core2 PF13369.1 CCF33425.1 - 3.5e-18 65.5 0.0 8.7e-18 64.2 0.0 1.7 2 0 0 2 2 2 1 Transglutaminase-like superfamily F-box-like PF12937.2 CCF33425.1 - 2.9e-08 33.2 1.3 1.2e-07 31.3 1.1 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 CCF33425.1 - 0.00036 20.1 0.3 0.00099 18.7 0.2 1.8 1 0 0 1 1 1 1 F-box domain YccV-like PF08755.6 CCF33425.1 - 0.005 16.7 1.3 0.014 15.2 0.7 1.9 2 1 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like Microtub_assoc PF07989.6 CCF33426.1 - 4.8e-21 74.3 0.7 7.2e-21 73.8 0.5 1.3 1 0 0 1 1 1 1 Microtubule associated EthD PF07110.6 CCF33427.1 - 0.00031 21.6 0.0 0.00059 20.7 0.0 1.5 1 1 0 1 1 1 1 EthD domain Sugar_tr PF00083.19 CCF33428.1 - 3.2e-126 421.5 30.5 3.7e-126 421.3 21.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF33428.1 - 2.5e-19 69.2 41.2 1.1e-11 44.0 11.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TauD PF02668.11 CCF33429.1 - 1.8e-09 37.6 0.6 2e-09 37.5 0.4 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family AAA_5 PF07728.9 CCF33430.1 - 8.5e-124 407.8 0.0 8.3e-22 77.4 0.0 9.7 9 0 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA PF00004.24 CCF33430.1 - 6.5e-29 100.8 0.1 0.00024 21.2 0.0 7.0 6 0 0 6 6 6 5 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.6 CCF33430.1 - 8.1e-29 99.8 0.0 1.1e-09 37.9 0.0 7.0 7 0 0 7 7 6 4 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CCF33430.1 - 3.7e-25 89.0 0.1 0.0025 18.5 0.0 7.5 7 0 0 7 7 6 5 AAA domain AAA_16 PF13191.1 CCF33430.1 - 1.2e-23 84.0 25.5 0.00025 21.1 0.0 9.9 9 2 0 9 9 8 5 AAA ATPase domain AAA_33 PF13671.1 CCF33430.1 - 9.9e-23 80.6 0.1 0.0016 18.3 0.0 8.4 7 1 0 7 7 6 4 AAA domain AAA_22 PF13401.1 CCF33430.1 - 2.6e-21 76.1 5.5 0.023 14.8 0.0 8.7 8 1 1 9 9 6 6 AAA domain AAA_14 PF13173.1 CCF33430.1 - 1.7e-19 69.9 0.0 0.00054 19.8 0.0 7.3 7 0 0 7 7 6 4 AAA domain Sigma54_activat PF00158.21 CCF33430.1 - 3.6e-19 68.8 0.0 0.047 13.1 0.0 6.9 7 0 0 7 7 6 5 Sigma-54 interaction domain AAA_18 PF13238.1 CCF33430.1 - 1.3e-18 67.5 2.9 0.081 13.2 0.0 7.0 7 0 0 7 7 6 4 AAA domain Sigma54_activ_2 PF14532.1 CCF33430.1 - 7.8e-17 61.6 1.5 0.0076 16.2 0.0 7.3 7 0 0 7 7 6 3 Sigma-54 interaction domain T2SE PF00437.15 CCF33430.1 - 1.5e-16 60.1 2.5 0.047 12.5 0.0 6.6 6 0 0 6 6 6 4 Type II/IV secretion system protein ABC_tran PF00005.22 CCF33430.1 - 1.7e-15 57.4 2.2 0.067 13.4 0.0 7.3 6 1 0 6 6 6 2 ABC transporter AAA_19 PF13245.1 CCF33430.1 - 1.1e-14 53.9 5.3 0.036 13.8 0.0 6.9 6 0 0 6 6 6 4 Part of AAA domain RNA_helicase PF00910.17 CCF33430.1 - 4e-14 52.6 0.8 0.45 10.6 0.0 6.6 6 0 0 6 6 6 3 RNA helicase NACHT PF05729.7 CCF33430.1 - 5.8e-14 52.0 5.3 0.054 13.1 0.1 6.2 6 0 0 6 6 5 4 NACHT domain UPF0079 PF02367.12 CCF33430.1 - 8.5e-14 51.2 4.6 0.013 15.1 0.0 6.1 6 0 0 6 6 6 4 Uncharacterised P-loop hydrolase UPF0079 AAA_29 PF13555.1 CCF33430.1 - 1.3e-12 47.0 0.5 0.19 11.2 0.0 6.4 6 0 0 6 6 6 2 P-loop containing region of AAA domain RuvB_N PF05496.7 CCF33430.1 - 5.6e-12 45.2 1.8 0.046 12.7 0.0 5.9 5 0 0 5 5 5 3 Holliday junction DNA helicase ruvB N-terminus Zeta_toxin PF06414.7 CCF33430.1 - 6.4e-12 44.9 6.9 0.048 12.7 0.0 7.3 8 0 0 8 8 6 2 Zeta toxin Arch_ATPase PF01637.13 CCF33430.1 - 6.4e-12 45.6 0.1 0.041 13.5 0.0 6.7 6 0 0 6 6 6 2 Archaeal ATPase AAA_28 PF13521.1 CCF33430.1 - 8.2e-12 45.3 4.4 0.22 11.5 0.0 7.2 7 0 0 7 7 6 1 AAA domain DUF258 PF03193.11 CCF33430.1 - 2e-11 43.3 1.7 0.3 10.2 0.1 6.2 6 0 0 6 6 6 2 Protein of unknown function, DUF258 Mg_chelatase PF01078.16 CCF33430.1 - 2.3e-11 43.2 4.3 6.1 5.9 0.0 9.2 10 0 0 10 10 9 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 CCF33430.1 - 2.4e-11 43.4 0.8 0.29 10.5 0.1 5.8 5 0 0 5 5 5 2 AAA domain AAA_30 PF13604.1 CCF33430.1 - 1.3e-10 41.1 0.0 1.7 8.2 0.0 7.3 6 1 0 6 6 6 1 AAA domain IstB_IS21 PF01695.12 CCF33430.1 - 3.2e-09 36.4 0.6 0.3 10.4 0.0 6.4 6 0 0 6 6 6 1 IstB-like ATP binding protein MobB PF03205.9 CCF33430.1 - 1.5e-08 34.4 3.8 3.5 7.3 0.0 6.7 6 0 0 6 6 6 0 Molybdopterin guanine dinucleotide synthesis protein B Miro PF08477.8 CCF33430.1 - 1.6e-08 35.0 3.3 6.7 7.2 0.0 6.5 6 0 0 6 6 6 0 Miro-like protein SRP54 PF00448.17 CCF33430.1 - 3.5e-08 33.1 1.4 0.42 10.0 0.1 5.1 5 0 0 5 5 5 1 SRP54-type protein, GTPase domain NTPase_1 PF03266.10 CCF33430.1 - 1.3e-07 31.5 9.3 0.9 9.2 0.0 7.2 7 0 0 7 7 6 2 NTPase AAA_2 PF07724.9 CCF33430.1 - 1.5e-07 31.4 0.0 1.5 8.6 0.0 6.0 5 0 0 5 5 5 1 AAA domain (Cdc48 subfamily) PduV-EutP PF10662.4 CCF33430.1 - 2e-07 30.5 2.8 0.048 13.1 0.0 5.3 5 0 0 5 5 5 2 Ethanolamine utilisation - propanediol utilisation DUF815 PF05673.8 CCF33430.1 - 3.2e-07 29.5 2.0 0.41 9.5 0.0 5.3 5 0 0 5 5 5 1 Protein of unknown function (DUF815) AAA_23 PF13476.1 CCF33430.1 - 7.9e-07 29.5 7.5 2.7 8.2 0.0 7.2 7 1 0 7 7 6 0 AAA domain cobW PF02492.14 CCF33430.1 - 4e-06 26.3 6.1 0.24 10.7 0.0 5.7 6 0 0 6 6 6 1 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.13 CCF33430.1 - 4.2e-06 26.4 0.3 0.31 10.5 0.0 5.6 6 0 0 6 6 5 1 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.1 CCF33430.1 - 3e-05 23.7 3.7 0.74 9.3 0.0 5.8 7 0 0 7 7 5 1 AAA domain NB-ARC PF00931.17 CCF33430.1 - 3.3e-05 22.8 6.0 0.53 9.0 0.0 5.9 6 0 0 6 6 6 1 NB-ARC domain TIP49 PF06068.8 CCF33430.1 - 3.5e-05 22.6 0.6 1.6 7.3 0.0 4.9 6 0 0 6 6 5 1 TIP49 C-terminus AAA_7 PF12775.2 CCF33430.1 - 4.4e-05 22.6 2.6 0.83 8.6 0.0 5.2 5 0 0 5 5 5 1 P-loop containing dynein motor region D3 Rad17 PF03215.10 CCF33430.1 - 6.1e-05 21.8 4.0 0.9 8.1 0.0 5.3 6 0 0 6 6 6 1 Rad17 cell cycle checkpoint protein MMR_HSR1 PF01926.18 CCF33430.1 - 0.00015 21.7 1.6 46 3.9 0.0 6.1 6 0 0 6 6 5 0 50S ribosome-binding GTPase AAA_24 PF13479.1 CCF33430.1 - 0.00015 21.4 7.3 8.8 5.8 0.0 6.6 8 0 0 8 8 6 0 AAA domain ResIII PF04851.10 CCF33430.1 - 0.00015 21.6 0.5 8.9 6.0 0.0 5.3 6 0 0 6 6 5 0 Type III restriction enzyme, res subunit KTI12 PF08433.5 CCF33430.1 - 0.00018 20.8 0.1 0.12 11.5 0.0 4.7 4 0 0 4 4 4 1 Chromatin associated protein KTI12 KaiC PF06745.8 CCF33430.1 - 0.00038 19.6 4.5 7.3 5.6 0.0 5.8 6 0 0 6 6 5 0 KaiC CPT PF07931.7 CCF33430.1 - 0.00053 19.6 4.6 23 4.5 0.0 7.0 8 1 0 8 8 5 0 Chloramphenicol phosphotransferase-like protein ATP_bind_1 PF03029.12 CCF33430.1 - 0.00065 19.3 4.1 21 4.5 0.0 5.7 6 0 0 6 6 6 0 Conserved hypothetical ATP binding protein DnaB_C PF03796.10 CCF33430.1 - 0.0021 17.0 0.5 0.31 9.9 0.0 3.3 3 0 0 3 3 3 1 DnaB-like helicase C terminal domain ArgK PF03308.11 CCF33430.1 - 0.0093 14.7 3.6 5 5.8 0.0 4.1 4 0 0 4 4 3 0 ArgK protein DEAD PF00270.24 CCF33430.1 - 0.01 15.3 1.7 5.7 6.4 0.0 4.4 6 0 0 6 6 3 0 DEAD/DEAH box helicase SRPRB PF09439.5 CCF33430.1 - 0.011 14.9 1.7 10 5.2 0.0 4.8 6 0 0 6 6 4 0 Signal recognition particle receptor beta subunit CbiA PF01656.18 CCF33430.1 - 0.011 15.1 1.0 7.8 5.8 0.0 4.0 4 0 0 4 4 4 0 CobQ/CobB/MinD/ParA nucleotide binding domain SMC_N PF02463.14 CCF33430.1 - 0.015 14.5 0.3 13 4.9 0.0 4.5 6 0 0 6 6 4 0 RecF/RecN/SMC N terminal domain PhoH PF02562.11 CCF33430.1 - 0.03 13.5 0.1 17 4.5 0.0 4.4 5 0 0 5 5 5 0 PhoH-like protein PRK PF00485.13 CCF33430.1 - 0.043 13.3 0.1 27 4.2 0.0 4.3 6 0 0 6 6 3 0 Phosphoribulokinase / Uridine kinase family AAA_10 PF12846.2 CCF33430.1 - 0.049 13.0 6.9 6.1 6.1 0.1 5.9 6 0 0 6 6 6 0 AAA-like domain ATP-synt_ab PF00006.20 CCF33430.1 - 0.065 12.7 0.1 18 4.7 0.0 4.1 5 0 0 5 5 4 0 ATP synthase alpha/beta family, nucleotide-binding domain tRNA_lig_kinase PF08303.6 CCF33430.1 - 0.12 12.2 0.9 0.89 9.4 0.1 2.7 2 0 0 2 2 2 0 tRNA ligase kinase domain AAA_6 PF12774.2 CCF33430.1 - 0.18 11.3 0.5 24 4.3 0.0 4.4 6 0 0 6 6 4 0 Hydrolytic ATP binding site of dynein motor region D1 Hpr_kinase_C PF07475.7 CCF33430.1 - 0.27 10.5 1.4 1.1 8.5 0.1 2.6 3 0 0 3 3 3 0 HPr Serine kinase C-terminal domain AAA_15 PF13175.1 CCF33430.1 - 2.9 6.8 0.1 83 2.0 0.0 2.9 3 0 0 3 3 3 0 AAA ATPase domain Ribosomal_L12 PF00542.14 CCF33431.1 - 5.8e-20 71.0 9.1 7.8e-19 67.4 4.6 2.3 2 0 0 2 2 2 2 Ribosomal protein L7/L12 C-terminal domain PP2C_C PF07830.8 CCF33431.1 - 0.09 12.8 0.1 2.8 8.0 0.0 2.5 2 0 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain CTK3 PF12243.3 CCF33432.1 - 9.4e-60 200.2 1.7 1.3e-59 199.7 1.2 1.2 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.3 CCF33432.1 - 1.2e-19 70.0 7.9 3.6e-19 68.5 5.5 1.8 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 C-terminus MAM33 PF02330.11 CCF33432.1 - 0.013 15.3 0.9 0.023 14.4 0.2 1.7 2 0 0 2 2 2 0 Mitochondrial glycoprotein P5CR_dimer PF14748.1 CCF33433.1 - 8.7e-35 118.9 2.4 1.8e-34 117.9 1.4 1.7 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.12 CCF33433.1 - 7.5e-13 48.7 1.3 5e-11 42.8 0.0 2.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent HMA PF00403.21 CCF33433.1 - 0.13 12.4 0.2 0.26 11.4 0.1 1.5 1 0 0 1 1 1 0 Heavy-metal-associated domain NAD_Gly3P_dh_N PF01210.18 CCF33433.1 - 0.19 11.4 1.4 0.64 9.7 0.0 2.2 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus SNF2_N PF00176.18 CCF33434.1 - 2.4e-51 174.3 0.0 2.9e-51 174.0 0.0 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain IGR PF09597.5 CCF33435.1 - 4.9e-22 77.5 0.0 9.5e-22 76.6 0.0 1.5 1 0 0 1 1 1 1 IGR protein motif Glyco_hydro_12 PF01670.11 CCF33436.1 - 5.7e-16 58.6 1.8 9.6e-16 57.9 0.3 2.0 2 1 1 3 3 3 1 Glycosyl hydrolase family 12 Peptidase_M20 PF01546.23 CCF33437.1 - 1.1e-06 28.2 4.1 1.9e-06 27.5 2.8 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 CCF33437.1 - 1.4e-06 28.0 0.1 4.1e-06 26.5 0.0 1.8 1 0 0 1 1 1 1 Peptidase dimerisation domain p450 PF00067.17 CCF33438.1 - 2.2e-34 118.8 0.0 7.2e-34 117.0 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 ComX PF05952.7 CCF33438.1 - 0.05 13.1 0.0 0.13 11.7 0.0 1.7 1 0 0 1 1 1 0 Bacillus competence pheromone ComX Man-6-P_recep PF02157.10 CCF33439.1 - 7.9e-10 38.2 0.0 1.3e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Mannose-6-phosphate receptor CIMR PF00878.13 CCF33439.1 - 2.4e-09 37.0 0.1 0.00032 20.4 0.0 2.3 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.5 CCF33439.1 - 6.4e-06 25.6 3.6 2.8e-05 23.5 1.5 2.5 1 1 1 2 2 2 1 Autophagy-related protein 27 Sugar_tr PF00083.19 CCF33440.1 - 3.3e-89 299.5 23.4 3.7e-89 299.3 16.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF33440.1 - 4e-36 124.4 51.6 7.9e-32 110.3 15.2 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DEAD PF00270.24 CCF33441.1 - 1.4e-39 135.3 0.2 2.7e-39 134.3 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF33441.1 - 9.3e-24 83.0 0.0 3.8e-14 52.2 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.10 CCF33441.1 - 6.9e-07 29.2 0.0 3.7e-06 26.8 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Methyltransf_23 PF13489.1 CCF33442.1 - 8.6e-13 48.3 0.0 1.1e-12 47.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF33442.1 - 1.1e-10 41.9 0.0 1.5e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF33442.1 - 2.4e-08 33.9 0.1 5.2e-08 32.9 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF33442.1 - 1.1e-07 32.2 0.0 1.7e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF33442.1 - 3.2e-07 30.9 0.0 4.7e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF33442.1 - 5e-06 26.1 0.0 7.1e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF33442.1 - 7.4e-05 23.0 0.0 0.00011 22.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF33442.1 - 0.09 12.1 0.0 0.2 11.0 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase small domain Sugar_tr PF00083.19 CCF33443.1 - 4e-81 272.9 17.8 4.5e-81 272.7 12.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF33443.1 - 1.4e-12 46.9 37.3 5.3e-12 45.1 23.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily WD40 PF00400.27 CCF33444.1 - 1.7e-18 65.7 3.4 0.0037 17.0 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat SDA1 PF05285.7 CCF33444.1 - 0.12 11.6 22.6 0.16 11.2 15.7 1.1 1 0 0 1 1 1 0 SDA1 SAPS PF04499.10 CCF33444.1 - 0.28 9.7 1.7 0.33 9.5 1.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein AAA_11 PF13086.1 CCF33445.1 - 1.2e-13 51.1 0.0 1.6e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CCF33445.1 - 2.7e-07 30.2 0.0 1.1e-06 28.3 0.0 2.0 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 CCF33445.1 - 7.1e-06 25.7 0.0 1.1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain PhoH PF02562.11 CCF33445.1 - 0.0083 15.3 0.0 0.014 14.6 0.0 1.3 1 0 0 1 1 1 1 PhoH-like protein IstB_IS21 PF01695.12 CCF33445.1 - 0.024 14.0 0.0 0.045 13.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.1 CCF33445.1 - 0.043 13.2 0.0 0.091 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 CCF33445.1 - 0.056 12.3 0.0 0.084 11.7 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_17 PF13207.1 CCF33445.1 - 0.14 12.9 0.0 1.9 9.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.4 CCF33445.1 - 0.18 10.7 0.0 0.41 9.5 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA PF00004.24 CCF33445.1 - 0.29 11.3 1.4 2.2 8.5 0.4 2.3 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) Pex24p PF06398.6 CCF33446.1 - 6e-79 265.4 0.0 7.4e-79 265.1 0.0 1.0 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Med3 PF11593.3 CCF33446.1 - 4.3 6.4 13.6 2.6 7.2 2.4 2.3 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal RabGAP-TBC PF00566.13 CCF33448.1 - 3.7e-32 111.5 0.0 5.8e-32 110.9 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3995 PF13160.1 CCF33450.1 - 0.001 19.1 4.4 0.0012 18.8 3.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3995) Shisa PF13908.1 CCF33450.1 - 0.91 9.6 2.9 1.5 8.9 2.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator CbiQ PF02361.11 CCF33450.1 - 1.2 8.6 6.7 1.3 8.4 4.6 1.1 1 0 0 1 1 1 0 Cobalt transport protein PIRT PF15099.1 CCF33450.1 - 7.7 5.7 9.2 12 5.1 6.4 1.4 1 1 0 1 1 1 0 Phosphoinositide-interacting protein family Exo_endo_phos PF03372.18 CCF33451.1 - 9.9e-21 74.8 0.4 1.6e-20 74.1 0.0 1.5 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.2 CCF33451.1 - 1.2e-13 50.3 2.1 1.1e-07 31.3 0.1 2.5 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CCF33451.1 - 1e-08 34.7 4.7 4.8e-05 23.0 0.7 2.4 2 1 2 4 4 4 2 Leucine rich repeat LRR_1 PF00560.28 CCF33451.1 - 0.0027 17.5 3.7 0.19 11.8 0.0 4.1 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_7 PF13504.1 CCF33451.1 - 0.0038 17.1 3.3 2.8 8.5 0.0 4.0 3 0 0 3 3 3 1 Leucine rich repeat LRR_6 PF13516.1 CCF33451.1 - 0.11 12.6 0.2 0.91 9.7 0.0 2.8 2 1 0 2 2 2 0 Leucine Rich repeat Fungal_trans_2 PF11951.3 CCF33452.1 - 5.1e-05 22.0 0.3 0.00016 20.4 0.2 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain p450 PF00067.17 CCF33453.1 - 9e-49 166.2 0.0 1.2e-48 165.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 polyprenyl_synt PF00348.12 CCF33454.1 - 1e-32 113.0 0.1 1.9e-32 112.1 0.1 1.4 1 0 0 1 1 1 1 Polyprenyl synthetase TPR_12 PF13424.1 CCF33454.1 - 0.033 14.1 0.2 2.8 7.9 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat MFS_1 PF07690.11 CCF33455.1 - 1.1e-38 132.8 27.3 1.1e-38 132.8 18.9 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Aminotran_1_2 PF00155.16 CCF33456.1 - 3.8e-44 151.1 0.0 4.5e-44 150.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II RNA_pol_Rpc4 PF05132.9 CCF33457.1 - 8.3e-25 87.2 0.8 1.2e-23 83.5 0.0 2.8 3 0 0 3 3 3 1 RNA polymerase III RPC4 UreD PF01774.12 CCF33458.1 - 9.4e-54 182.0 0.0 1.1e-53 181.8 0.0 1.1 1 0 0 1 1 1 1 UreD urease accessory protein STAG PF08514.6 CCF33459.1 - 1.1e-26 92.8 0.5 3.6e-26 91.1 0.3 1.9 1 0 0 1 1 1 1 STAG domain HEAT_2 PF13646.1 CCF33459.1 - 2e-07 31.2 0.0 0.0052 17.0 0.0 3.7 3 0 0 3 3 3 2 HEAT repeats DUF1090 PF06476.7 CCF33459.1 - 0.0019 17.8 0.6 0.0068 16.0 0.4 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1090) Cnd1 PF12717.2 CCF33459.1 - 0.003 17.4 0.2 0.012 15.4 0.0 2.1 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 NAPRTase PF04095.11 CCF33459.1 - 0.11 11.8 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase (NAPRTase) family PMR5N PF14416.1 CCF33460.1 - 2.8 8.0 7.8 11 6.2 1.6 3.2 2 1 1 3 3 3 0 PMR5 N terminal Domain Cu_amine_oxid PF01179.15 CCF33464.1 - 2.5e-53 181.2 0.0 3.3e-53 180.8 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.11 CCF33464.1 - 6.6e-07 29.3 0.0 1.6e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.11 CCF33464.1 - 0.012 15.7 0.0 0.022 14.8 0.0 1.4 1 0 0 1 1 1 0 Copper amine oxidase, N3 domain Gly_transf_sug PF04488.10 CCF33465.1 - 1.4e-13 51.0 0.0 2.8e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif SH3_1 PF00018.23 CCF33466.1 - 1.5e-26 91.5 0.0 3.8e-13 48.5 0.0 2.7 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.1 CCF33466.1 - 2.6e-18 65.3 0.1 1.9e-08 33.7 0.0 2.9 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.12 CCF33466.1 - 6.1e-13 48.0 0.0 5.6e-08 32.1 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.19 CCF33466.1 - 9.2e-13 47.9 0.0 1.9e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 PX domain PB1 PF00564.19 CCF33466.1 - 7.2e-09 35.2 0.1 1.1e-08 34.6 0.1 1.3 1 0 0 1 1 1 1 PB1 domain Rad60-SLD PF11976.3 CCF33466.1 - 0.12 12.0 0.3 0.71 9.5 0.2 2.3 1 1 1 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Pex14_N PF04695.8 CCF33466.1 - 0.67 9.9 14.4 0.21 11.6 1.9 3.2 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ADH_zinc_N PF00107.21 CCF33467.1 - 1.1e-24 86.4 0.3 1.6e-24 85.9 0.2 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF33467.1 - 9e-15 55.7 1.3 1.1e-14 55.4 0.3 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.16 CCF33467.1 - 0.0003 20.4 0.0 0.00054 19.5 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.1 CCF33467.1 - 0.021 15.0 0.1 0.04 14.1 0.1 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding NAD_binding_10 PF13460.1 CCF33467.1 - 0.026 14.5 2.5 0.05 13.6 1.5 1.7 1 1 0 1 1 1 0 NADH(P)-binding DUF871 PF05913.6 CCF33467.1 - 0.13 11.0 0.1 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF871) Glyco_hydro_3 PF00933.16 CCF33471.1 - 1e-43 149.4 0.0 1.4e-43 148.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_1 PF00583.19 CCF33471.1 - 0.00084 19.3 0.2 0.003 17.5 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Glyco_hydro_3_C PF01915.17 CCF33471.1 - 0.00099 18.6 0.0 0.002 17.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_31 PF01055.21 CCF33472.1 - 2e-113 379.5 0.3 2.4e-113 379.3 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 CCF33472.1 - 3.7e-15 55.5 0.2 2.3e-14 52.9 0.0 2.5 3 0 0 3 3 3 1 Galactose mutarotase-like adh_short PF00106.20 CCF33473.1 - 0.028 14.3 0.1 0.16 11.8 0.0 2.1 2 0 0 2 2 2 0 short chain dehydrogenase FAD_binding_4 PF01565.18 CCF33474.1 - 9e-20 70.5 4.1 1.9e-19 69.5 2.9 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 CCF33474.1 - 3.4e-09 36.4 0.3 6.3e-09 35.5 0.2 1.5 1 0 0 1 1 1 1 Berberine and berberine like DUF3579 PF12112.3 CCF33474.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3579) UbiA PF01040.13 CCF33476.1 - 2.9e-19 69.3 10.4 3.9e-19 68.8 7.2 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family TraX PF05857.6 CCF33476.1 - 0.28 10.7 2.8 0.27 10.8 0.3 2.0 1 1 1 2 2 2 0 TraX protein FrhB_FdhB_C PF04432.8 CCF33477.1 - 0.071 12.5 1.1 1.9 7.8 0.0 2.2 2 0 0 2 2 2 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus zf-B_box PF00643.19 CCF33477.1 - 5.8 6.8 12.0 0.61 10.0 2.6 2.7 2 1 0 2 2 2 0 B-box zinc finger FYVE_2 PF02318.11 CCF33477.1 - 6.8 6.6 10.9 0.25 11.2 1.7 2.6 3 0 0 3 3 3 0 FYVE-type zinc finger MRP-L20 PF12824.2 CCF33478.1 - 4.3e-49 166.6 1.2 5.1e-49 166.3 0.9 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.6 CCF33478.1 - 5.2e-05 23.1 0.0 8.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Neugrin HEV_ORF1 PF02444.11 CCF33478.1 - 0.11 12.7 4.1 0.13 12.4 1.8 1.7 2 0 0 2 2 2 0 Hepatitis E virus ORF-2 (Putative capsid protein) KxDL PF10241.4 CCF33479.1 - 2.9e-30 104.0 2.6 4e-30 103.5 1.8 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein DUF2385 PF09539.5 CCF33479.1 - 0.015 15.6 0.5 0.031 14.6 0.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2385) Mating_C PF12737.2 CCF33479.1 - 0.073 11.9 6.4 1.2 7.8 0.8 2.3 2 1 0 2 2 2 0 C-terminal domain of homeodomain 1 DUF883 PF05957.8 CCF33479.1 - 0.17 12.2 5.8 2.4 8.6 1.1 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) ATP-synt_F PF01990.12 CCF33481.1 - 1.5e-32 111.8 0.1 1.8e-32 111.5 0.1 1.1 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DXP_synthase_N PF13292.1 CCF33481.1 - 0.031 13.2 0.0 0.031 13.2 0.0 1.1 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase E1_DerP2_DerF2 PF02221.10 CCF33482.1 - 2.6e-25 89.2 0.4 3.1e-25 88.9 0.3 1.1 1 0 0 1 1 1 1 ML domain TRP_N PF14558.1 CCF33482.1 - 0.05 13.6 0.0 0.091 12.7 0.0 1.6 1 1 0 1 1 1 0 ML-like domain Cpn10 PF00166.16 CCF33483.1 - 3.2e-27 94.3 0.0 3.6e-27 94.1 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Phenyl_P_gamma PF09662.5 CCF33483.1 - 0.15 11.7 0.0 0.32 10.7 0.0 1.5 1 1 0 1 1 1 0 Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma) Pkinase PF00069.20 CCF33484.1 - 1.1e-56 191.9 0.0 1.9e-56 191.0 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF33484.1 - 2.9e-20 72.4 0.0 5.3e-20 71.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CCF33484.1 - 0.035 13.8 0.1 0.071 12.8 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.1 CCF33484.1 - 0.25 10.2 0.0 0.44 9.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Ribosomal_L11_N PF03946.9 CCF33485.1 - 7.4e-26 89.3 0.1 1.3e-25 88.6 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 CCF33485.1 - 2.3e-24 85.3 0.2 4.9e-24 84.2 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain Svf1 PF08622.5 CCF33486.1 - 1e-126 422.3 0.0 1.2e-126 422.0 0.0 1.1 1 0 0 1 1 1 1 Svf1-like P22_Cro PF14549.1 CCF33486.1 - 0.027 14.2 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 DNA-binding transcriptional regulator Cro CrtC PF07143.6 CCF33486.1 - 0.046 13.0 0.0 0.072 12.3 0.0 1.3 1 0 0 1 1 1 0 Hydroxyneurosporene synthase (CrtC) Histone PF00125.19 CCF33487.1 - 6e-10 39.1 0.0 8.7e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PCP_red PF08369.5 CCF33487.1 - 0.045 13.6 0.2 0.67 9.8 0.1 2.3 2 0 0 2 2 2 0 Proto-chlorophyllide reductase 57 kD subunit CBFD_NFYB_HMF PF00808.18 CCF33487.1 - 0.083 12.9 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Acetyltransf_1 PF00583.19 CCF33488.1 - 0.0039 17.2 0.0 0.0083 16.1 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF33488.1 - 0.019 15.1 0.0 0.035 14.2 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Mis12 PF05859.7 CCF33490.1 - 1.5e-35 122.1 0.0 2.7e-35 121.3 0.0 1.4 1 0 0 1 1 1 1 Mis12 protein Peptidase_M14 PF00246.19 CCF33491.1 - 2.3e-63 214.4 0.0 2.8e-63 214.1 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase PPR_2 PF13041.1 CCF33492.1 - 8e-27 92.9 0.0 3.2e-11 43.0 0.0 6.0 4 3 3 7 7 7 6 PPR repeat family PPR_3 PF13812.1 CCF33492.1 - 1.1e-17 62.7 6.1 0.0063 16.7 0.0 10.3 10 1 0 10 10 10 4 Pentatricopeptide repeat domain PPR PF01535.15 CCF33492.1 - 1.7e-11 43.2 0.3 0.038 13.9 0.1 6.4 7 0 0 7 7 7 3 PPR repeat PPR_1 PF12854.2 CCF33492.1 - 2.4e-08 33.3 0.0 0.0076 15.7 0.0 4.9 4 0 0 4 4 4 2 PPR repeat ECSIT PF06239.6 CCF33492.1 - 0.0015 17.4 0.0 5.4 5.7 0.0 4.0 3 2 2 5 5 5 2 Evolutionarily conserved signalling intermediate in Toll pathway Amidohydro_5 PF13594.1 CCF33493.1 - 6.4e-15 54.7 0.9 9.5e-15 54.1 0.6 1.3 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 CCF33493.1 - 8.4e-08 32.2 0.3 1.2e-07 31.7 0.2 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 CCF33493.1 - 4.7e-06 26.8 0.3 6.5e-06 26.3 0.2 1.2 1 0 0 1 1 1 1 Amidohydrolase Urease_alpha PF00449.15 CCF33493.1 - 0.0034 17.5 0.5 0.025 14.6 0.2 2.0 2 0 0 2 2 2 1 Urease alpha-subunit, N-terminal domain Amidohydro_3 PF07969.6 CCF33493.1 - 0.0055 15.9 0.1 0.007 15.6 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase family Asp_Glu_race PF01177.17 CCF33494.1 - 1.1e-29 103.8 0.6 3.7e-29 102.1 0.2 1.9 2 0 0 2 2 2 1 Asp/Glu/Hydantoin racemase CN_hydrolase PF00795.17 CCF33494.1 - 1.5e-21 76.6 0.0 2.6e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase zf-LYAR PF08790.6 CCF33494.1 - 5.1 6.8 6.2 0.23 11.2 0.3 1.7 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger Fungal_trans PF04082.13 CCF33495.1 - 1.9e-22 79.3 1.7 3.3e-22 78.5 1.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF33495.1 - 0.0049 16.7 10.0 0.0093 15.8 6.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NAD_binding_4 PF07993.7 CCF33496.1 - 1.8e-42 144.9 0.0 2.4e-42 144.5 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.16 CCF33496.1 - 9.7e-11 41.5 0.0 1.7e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.20 CCF33496.1 - 9.8e-10 38.5 0.0 2.4e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.20 CCF33496.1 - 7.4e-06 25.9 4.4 1.6e-05 24.9 0.1 3.3 3 1 0 3 3 3 1 short chain dehydrogenase KR PF08659.5 CCF33496.1 - 0.00013 21.6 0.7 0.0011 18.6 0.2 2.6 2 2 0 2 2 2 1 KR domain 3Beta_HSD PF01073.14 CCF33496.1 - 0.00063 18.5 0.0 0.0014 17.3 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DUF1903 PF08991.5 CCF33497.1 - 0.059 13.5 0.2 0.076 13.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1903) CYSTM PF12734.2 CCF33500.1 - 6.2e-06 26.1 37.0 6.2e-06 26.1 25.6 4.8 2 1 1 3 3 3 1 Cysteine-rich TM module stress tolerance Arrestin_N PF00339.24 CCF33501.1 - 7.2e-20 71.3 0.1 1e-17 64.3 0.0 3.0 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 CCF33501.1 - 2.8e-06 27.4 0.0 0.0022 18.0 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Ribosomal_L19 PF01245.15 CCF33501.1 - 0.074 12.8 0.2 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L19 ketoacyl-synt PF00109.21 CCF33502.1 - 1.7e-65 221.0 0.1 4.7e-65 219.5 0.1 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 CCF33502.1 - 6.9e-46 157.0 0.5 3.7e-45 154.6 0.3 2.1 1 1 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.1 CCF33502.1 - 1.1e-44 152.8 0.0 1.8e-44 152.1 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.17 CCF33502.1 - 2.4e-30 104.8 0.0 7.9e-30 103.1 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 CCF33502.1 - 0.00029 19.9 0.8 0.0006 18.8 0.0 1.8 2 0 0 2 2 2 1 Thiolase, N-terminal domain DUF1788 PF08747.6 CCF33502.1 - 0.11 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1788) DUF3554 PF12074.3 CCF33503.1 - 2.2e-84 283.7 3.1 9.4e-84 281.7 1.7 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3554) HEAT_2 PF13646.1 CCF33503.1 - 3.5e-25 88.1 15.0 1.1e-09 38.4 0.0 10.5 6 2 3 9 9 9 4 HEAT repeats HEAT PF02985.17 CCF33503.1 - 1.3e-22 77.7 16.0 0.0082 16.1 0.0 14.0 16 0 0 16 16 16 6 HEAT repeat HEAT_EZ PF13513.1 CCF33503.1 - 1.1e-19 70.2 28.7 1.7e-05 25.1 0.0 15.2 15 2 4 19 19 19 4 HEAT-like repeat Vac14_Fab1_bd PF12755.2 CCF33503.1 - 1.3e-07 31.8 0.0 0.17 12.3 0.0 5.6 4 1 1 5 5 5 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.3 CCF33503.1 - 0.0042 16.4 0.0 1 8.6 0.0 3.9 1 1 3 4 4 4 2 CLASP N terminal Ecm29 PF13001.2 CCF33503.1 - 0.011 14.2 0.1 0.46 8.9 0.0 3.2 2 1 2 4 4 4 0 Proteasome stabiliser SPT6_acidic PF14632.1 CCF33504.1 - 0.11 12.7 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Acidic N-terminal SPT6 DLIC PF05783.6 CCF33504.1 - 0.46 9.0 2.9 0.48 9.0 2.0 1.0 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Cpn60_TCP1 PF00118.19 CCF33505.1 - 2.3e-24 85.8 0.0 3.7e-24 85.1 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family SusD-like PF12741.2 CCF33505.1 - 0.33 9.4 0.1 0.53 8.8 0.0 1.2 1 0 0 1 1 1 0 Susd and RagB outer membrane lipoprotein CUE PF02845.11 CCF33506.1 - 1.7e-07 30.5 0.0 3e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 CUE domain DUF3697 PF12478.3 CCF33506.1 - 0.025 14.2 1.8 0.051 13.2 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin-associated protein 2 UBA PF00627.26 CCF33506.1 - 0.14 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 UBA/TS-N domain PAP2_3 PF14378.1 CCF33509.1 - 5.1e-19 68.5 6.5 3.8e-13 49.4 2.3 2.3 2 0 0 2 2 2 2 PAP2 superfamily RtcB PF01139.12 CCF33509.1 - 0.0025 16.8 0.0 0.0034 16.4 0.0 1.1 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB DUF1212 PF06738.7 CCF33509.1 - 0.088 12.2 0.4 0.19 11.1 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1212) Inositol_P PF00459.20 CCF33511.1 - 2.2e-35 122.3 0.0 4.9e-35 121.1 0.0 1.5 1 1 0 1 1 1 1 Inositol monophosphatase family Glyco_hydro_88 PF07470.8 CCF33513.1 - 1.8e-60 204.8 3.7 2.2e-60 204.4 2.6 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.8 CCF33513.1 - 0.0033 16.7 0.3 0.12 11.6 0.1 2.6 1 1 1 2 2 2 1 D-glucuronyl C5-epimerase C-terminus DUF1680 PF07944.7 CCF33513.1 - 0.0037 15.5 0.0 0.0067 14.7 0.0 1.3 1 0 0 1 1 1 1 Putative glycosyl hydrolase of unknown function (DUF1680) Arylsulfotran_2 PF14269.1 CCF33515.1 - 0.069 12.2 0.0 0.085 11.9 0.0 1.1 1 0 0 1 1 1 0 Arylsulfotransferase (ASST) Ribosomal_L37e PF01907.14 CCF33515.1 - 0.33 10.7 9.0 0.63 9.8 6.2 1.5 1 0 0 1 1 1 0 Ribosomal protein L37e N2227 PF07942.7 CCF33516.1 - 1.4e-61 207.8 0.0 2.1e-61 207.2 0.0 1.3 1 0 0 1 1 1 1 N2227-like protein Methyltransf_12 PF08242.7 CCF33516.1 - 1e-05 25.8 0.5 8.7e-05 22.9 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF33516.1 - 0.00017 21.9 0.0 0.00062 20.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF33516.1 - 0.00021 21.8 0.0 0.00061 20.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF33516.1 - 0.00046 19.9 0.0 0.00099 18.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF33516.1 - 0.014 15.0 0.0 0.13 11.8 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain DUF1153 PF06627.6 CCF33516.1 - 0.026 14.3 0.0 0.063 13.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1153) Cellulase PF00150.13 CCF33517.1 - 1.8e-30 106.0 0.0 2.7e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Kazal_1 PF00050.16 CCF33518.1 - 0.012 15.6 3.1 0.012 15.6 2.2 1.7 2 0 0 2 2 2 0 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.10 CCF33518.1 - 0.5 10.3 6.1 0.61 10.0 3.5 1.7 2 0 0 2 2 2 0 Kazal-type serine protease inhibitor domain Sugar_tr PF00083.19 CCF33519.1 - 4.3e-73 246.4 22.7 5.3e-73 246.1 15.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF33519.1 - 2.9e-15 55.8 29.0 2.9e-15 55.8 20.1 2.3 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.1 CCF33519.1 - 6.1e-06 24.8 29.0 7.5e-05 21.3 0.8 3.9 1 1 2 4 4 4 2 MFS/sugar transport protein p450 PF00067.17 CCF33520.1 - 1.2e-56 192.1 0.0 1.4e-56 191.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Clr5 PF14420.1 CCF33521.1 - 7.7e-12 44.9 0.1 2.3e-11 43.4 0.0 1.9 1 0 0 1 1 1 1 Clr5 domain Ank_2 PF12796.2 CCF33521.1 - 0.042 14.1 0.1 0.074 13.3 0.1 1.4 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Tetraspannin PF00335.15 CCF33522.1 - 0.0021 17.3 5.9 0.029 13.6 4.1 2.1 1 1 0 1 1 1 1 Tetraspanin family PI-PLC-X PF00388.14 CCF33523.1 - 1.3e-48 164.0 0.0 2e-48 163.5 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 CCF33523.1 - 1.4e-27 95.9 0.0 2.4e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain Ribosomal_L36e PF01158.13 CCF33524.1 - 0.011 15.6 1.5 0.011 15.6 1.0 1.8 2 0 0 2 2 2 0 Ribosomal protein L36e PRP1_N PF06424.7 CCF33524.1 - 1.5 9.1 9.1 0.076 13.3 0.5 2.7 3 0 0 3 3 3 0 PRP1 splicing factor, N-terminal DEAD PF00270.24 CCF33525.1 - 2.3e-42 144.3 0.2 3.4e-42 143.8 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF33525.1 - 3.4e-17 62.0 0.0 7.5e-17 60.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 CCF33525.1 - 1.1e-15 56.8 0.1 2.2e-15 55.9 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.10 CCF33525.1 - 0.022 14.5 0.0 0.047 13.5 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Ank_2 PF12796.2 CCF33526.1 - 5.3e-72 238.2 9.5 7.1e-24 83.9 0.1 5.5 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank PF00023.25 CCF33526.1 - 6.7e-61 199.2 13.4 5.4e-09 35.4 0.0 10.4 9 1 0 9 9 9 8 Ankyrin repeat Ank_4 PF13637.1 CCF33526.1 - 9.6e-46 153.3 12.0 8.2e-11 42.1 0.0 7.7 2 2 5 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF33526.1 - 1.7e-42 139.1 3.1 5.9e-05 22.9 0.0 9.9 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.1 CCF33526.1 - 2.2e-41 138.9 4.8 2.7e-07 30.5 0.0 8.0 1 1 6 8 8 8 7 Ankyrin repeats (many copies) NACHT PF05729.7 CCF33526.1 - 1.1e-17 64.1 0.1 2.3e-17 63.1 0.1 1.5 1 0 0 1 1 1 1 NACHT domain PNP_UDP_1 PF01048.15 CCF33526.1 - 3.1e-06 26.3 0.0 0.0016 17.4 0.0 2.3 2 0 0 2 2 2 2 Phosphorylase superfamily AAA_16 PF13191.1 CCF33526.1 - 3.4e-05 23.9 0.2 0.00042 20.3 0.0 2.8 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 CCF33526.1 - 0.00039 20.5 0.2 0.0018 18.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.17 CCF33526.1 - 0.0013 17.6 0.7 0.0026 16.6 0.0 1.8 2 0 0 2 2 2 1 NB-ARC domain RVP PF00077.15 CCF33526.1 - 0.0017 18.2 4.3 4.9 7.1 0.0 5.0 3 1 2 5 5 5 1 Retroviral aspartyl protease AAA PF00004.24 CCF33526.1 - 0.0035 17.5 0.0 0.01 16.0 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 CCF33526.1 - 0.0038 17.1 0.1 0.016 15.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 CCF33526.1 - 0.011 15.4 0.0 0.023 14.3 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase KaiC PF06745.8 CCF33526.1 - 0.017 14.2 0.0 0.042 12.9 0.0 1.6 1 0 0 1 1 1 0 KaiC DUF1110 PF06533.7 CCF33526.1 - 0.02 14.7 6.2 1.5 8.5 0.0 4.5 3 2 2 5 5 5 0 Protein of unknown function (DUF1110) RNA_helicase PF00910.17 CCF33526.1 - 0.025 14.7 0.0 0.068 13.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Viral_helicase1 PF01443.13 CCF33526.1 - 0.072 12.5 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase KAP_NTPase PF07693.9 CCF33526.1 - 0.081 11.9 0.0 7 5.5 0.0 2.2 1 1 1 2 2 2 0 KAP family P-loop domain BCS1_N PF08740.6 CCF33527.1 - 7.5e-27 94.1 0.0 1.1e-26 93.6 0.0 1.2 1 0 0 1 1 1 1 BCS1 N terminal MIF4G PF02854.14 CCF33528.1 - 4.7e-61 205.8 0.0 9.7e-31 106.8 0.0 3.4 3 0 0 3 3 3 3 MIF4G domain Upf2 PF04050.9 CCF33528.1 - 1.6e-57 194.0 12.5 1.6e-57 194.0 8.7 1.8 2 0 0 2 2 2 1 Up-frameshift suppressor 2 CBP4 PF07960.6 CCF33528.1 - 0.0024 17.4 1.2 0.016 14.8 0.0 2.7 2 0 0 2 2 2 1 CBP4 Pkinase_Tyr PF07714.12 CCF33529.1 - 0.028 13.4 0.0 0.046 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Ribonuc_L-PSP PF01042.16 CCF33531.1 - 2.9e-19 68.9 0.0 3.5e-19 68.7 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Acp26Ab PF05777.7 CCF33532.1 - 0.075 13.4 0.0 0.1 13.0 0.0 1.1 1 0 0 1 1 1 0 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) DUF1145 PF06611.7 CCF33532.1 - 0.091 12.4 0.1 0.62 9.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1145) zf-C2H2 PF00096.21 CCF33533.1 - 3.4e-09 36.4 11.6 0.00027 21.1 3.9 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CCF33533.1 - 2.1e-08 34.0 17.9 6.7e-07 29.2 2.6 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 CCF33533.1 - 4.5e-06 26.6 10.3 0.014 15.7 2.9 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CCF33533.1 - 0.013 15.6 2.4 0.013 15.6 1.7 2.3 2 2 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 CCF33533.1 - 0.053 13.4 8.4 0.099 12.5 1.5 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-UBR PF02207.15 CCF33533.1 - 0.12 12.1 2.3 0.16 11.7 1.6 1.2 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) GAGA PF09237.6 CCF33533.1 - 0.27 10.8 4.9 8.3 6.0 0.1 2.2 1 1 1 2 2 2 0 GAGA factor Cupin_1 PF00190.17 CCF33538.1 - 9.6e-24 83.4 0.0 2.2e-12 46.6 0.0 2.2 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.6 CCF33538.1 - 6.1e-23 80.1 0.1 3e-12 45.8 0.1 2.5 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.7 CCF33538.1 - 9.5e-10 37.7 0.1 0.00015 21.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.14 CCF33538.1 - 3.1e-07 30.1 0.0 0.00034 20.3 0.0 2.5 2 0 0 2 2 2 2 AraC-like ligand binding domain Cupin_6 PF12852.2 CCF33538.1 - 1e-05 25.2 0.0 0.00078 19.1 0.0 2.3 2 0 0 2 2 2 1 Cupin MannoseP_isomer PF01050.13 CCF33538.1 - 1.7e-05 24.5 0.0 0.0058 16.2 0.0 2.2 2 0 0 2 2 2 2 Mannose-6-phosphate isomerase FdtA PF05523.6 CCF33538.1 - 0.00012 21.5 0.0 0.0085 15.5 0.0 2.2 2 0 0 2 2 2 1 WxcM-like, C-terminal 3-HAO PF06052.7 CCF33538.1 - 0.00014 21.3 0.0 0.00099 18.5 0.0 2.0 2 0 0 2 2 2 1 3-hydroxyanthranilic acid dioxygenase 2OG-FeII_Oxy_5 PF13759.1 CCF33538.1 - 0.12 12.6 0.1 25 5.2 0.1 3.1 2 1 1 3 3 3 0 Putative 2OG-Fe(II) oxygenase ARD PF03079.9 CCF33538.1 - 0.14 12.1 0.0 0.54 10.1 0.0 1.8 2 0 0 2 2 2 0 ARD/ARD' family MS_channel PF00924.13 CCF33540.1 - 9.1e-19 67.5 2.5 1.5e-18 66.8 1.7 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_7 PF13499.1 CCF33540.1 - 0.022 14.8 0.0 0.055 13.6 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.27 CCF33540.1 - 0.14 11.5 0.2 0.38 10.1 0.2 1.8 1 0 0 1 1 1 0 EF hand DLH PF01738.13 CCF33541.1 - 1.6e-24 86.4 0.0 2.6e-24 85.7 0.0 1.4 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 CCF33541.1 - 1.5e-05 24.8 0.0 2e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family BAAT_C PF08840.6 CCF33541.1 - 0.077 12.6 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.13 CCF33541.1 - 0.11 11.9 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Glyco_hydro_12 PF01670.11 CCF33542.1 - 4.9e-21 75.1 0.1 5.4e-21 75.0 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 Aldose_epim PF01263.15 CCF33542.1 - 0.069 12.2 0.0 0.076 12.1 0.0 1.1 1 0 0 1 1 1 0 Aldose 1-epimerase LRR_4 PF12799.2 CCF33543.1 - 3.2e-05 23.4 4.3 11 5.7 0.0 6.1 6 0 0 6 6 6 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 CCF33543.1 - 0.1 12.7 6.9 2.4 8.5 0.0 4.5 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.28 CCF33543.1 - 0.45 10.7 4.6 31 5.1 0.0 4.9 5 0 0 5 5 5 0 Leucine Rich Repeat Peptidase_S9 PF00326.16 CCF33544.1 - 3.1e-55 186.6 0.0 5.1e-55 185.9 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CCF33544.1 - 8.9e-10 38.4 0.0 1.6e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF33544.1 - 1.3e-06 28.4 0.2 4e-06 26.8 0.1 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family PD40 PF07676.7 CCF33544.1 - 0.0064 16.1 0.0 0.063 12.9 0.0 2.5 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat AXE1 PF05448.7 CCF33544.1 - 0.015 13.8 0.1 0.18 10.2 0.0 2.0 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) NuA4 PF09340.5 CCF33545.1 - 3e-23 81.2 0.1 3e-23 81.2 0.0 1.8 2 0 0 2 2 2 1 Histone acetyltransferase subunit NuA4 Med13_C PF06333.7 CCF33545.1 - 0.26 9.7 2.0 0.24 9.8 1.4 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal SpaB_C PF14028.1 CCF33545.1 - 0.51 9.8 2.9 0.63 9.5 1.8 1.3 1 1 0 1 1 1 0 SpaB C-terminal domain Ndc1_Nup PF09531.5 CCF33545.1 - 1.9 6.8 5.7 2.6 6.3 4.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PAS_3 PF08447.6 CCF33547.1 - 4.5e-15 55.5 0.0 1.4e-11 44.3 0.0 2.8 3 0 0 3 3 3 2 PAS fold PAS_9 PF13426.1 CCF33547.1 - 4.4e-11 43.0 0.0 2.5e-05 24.5 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS_11 PF14598.1 CCF33547.1 - 5.1e-08 32.8 0.0 3.4e-07 30.2 0.0 2.2 2 0 0 2 2 2 1 PAS domain PAS PF00989.19 CCF33547.1 - 9.3e-08 31.8 0.0 0.00015 21.5 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.5 CCF33547.1 - 0.00065 19.7 0.0 0.11 12.5 0.0 2.9 2 0 0 2 2 2 1 PAS fold Mito_fiss_reg PF05308.6 CCF33547.1 - 0.45 9.8 10.4 0.073 12.4 0.5 2.3 2 0 0 2 2 2 0 Mitochondrial fission regulator DUF605 PF04652.11 CCF33547.1 - 0.46 9.8 32.9 0.25 10.6 3.6 2.2 2 0 0 2 2 2 0 Vta1 like Yip1 PF04893.12 CCF33548.1 - 1.5e-11 44.0 17.5 1.8e-11 43.8 11.8 1.5 1 1 0 1 1 1 1 Yip1 domain Ran_BP1 PF00638.13 CCF33549.1 - 3e-12 46.6 1.2 2.7e-05 24.1 0.0 2.8 3 0 0 3 3 3 2 RanBP1 domain DEAD PF00270.24 CCF33550.1 - 4.3e-27 94.6 0.0 3.1e-26 91.8 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF1998 PF09369.5 CCF33550.1 - 6.1e-13 49.1 0.2 1.7e-12 47.6 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.26 CCF33550.1 - 1.4e-09 37.6 0.1 5e-09 35.8 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CDT1 PF08839.6 CCF33550.1 - 0.019 14.9 0.0 0.047 13.6 0.0 1.7 1 0 0 1 1 1 0 DNA replication factor CDT1 like Na_Ca_ex PF01699.19 CCF33551.1 - 7.5e-24 83.9 22.7 4e-13 49.1 2.8 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF4536 PF15055.1 CCF33551.1 - 0.0075 16.3 0.3 0.026 14.5 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4536) NADH-u_ox-rdase PF10785.4 CCF33551.1 - 0.057 13.6 1.6 0.95 9.7 0.0 3.3 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit Sugarporin_N PF11471.3 CCF33551.1 - 0.16 11.6 0.3 0.64 9.7 0.2 2.1 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension DEAD PF00270.24 CCF33553.1 - 2e-42 144.5 0.0 3.1e-42 143.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF33553.1 - 1.1e-23 82.9 0.1 2.2e-23 81.8 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain GatB_Yqey PF02637.13 CCF33555.1 - 5.8e-11 42.3 0.0 8.2e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 GatB domain RabGAP-TBC PF00566.13 CCF33556.1 - 3.8e-36 124.5 5.4 1.3e-35 122.8 3.7 1.9 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Cupin_3 PF05899.7 CCF33557.1 - 0.12 11.7 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Sugar_tr PF00083.19 CCF33558.1 - 8.2e-115 383.9 27.0 9.6e-115 383.7 18.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF33558.1 - 1.5e-19 69.9 25.2 1.5e-19 69.9 17.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF33558.1 - 0.00022 19.5 0.3 0.00022 19.5 0.2 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) zf-RNPHF PF08080.7 CCF33558.1 - 0.011 15.2 0.3 1.2 8.7 0.0 3.1 3 0 0 3 3 3 0 RNPHF zinc finger Peptidase_M3 PF01432.15 CCF33559.1 - 5.5e-124 414.6 0.0 7e-124 414.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 Mto2_bdg PF12808.2 CCF33560.1 - 0.13 12.3 0.5 0.19 11.8 0.4 1.2 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Glyco_hydro_61 PF03443.9 CCF33561.1 - 1.2e-46 159.3 0.0 1.8e-46 158.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DUF1970 PF09301.5 CCF33561.1 - 6.7 6.7 8.7 0.71 9.9 0.1 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF1970) CHD5 PF04420.9 CCF33563.1 - 0.0057 16.3 0.4 0.46 10.1 0.2 3.2 3 0 0 3 3 3 1 CHD5-like protein DUF996 PF06195.8 CCF33563.1 - 0.086 12.8 7.5 0.047 13.6 1.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF996) p450 PF00067.17 CCF33564.1 - 1.2e-42 146.0 0.0 3.6e-28 98.3 0.0 2.7 2 1 0 2 2 2 2 Cytochrome P450 Peptidase_S10 PF00450.17 CCF33565.1 - 1.7e-51 175.6 3.5 1.9e-51 175.5 2.4 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase DUF1057 PF06342.7 CCF33565.1 - 0.068 11.9 1.9 0.05 12.4 0.2 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1057) Kinesin PF00225.18 CCF33569.1 - 2.1e-95 319.2 0.0 3.9e-95 318.3 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain LMP PF04778.7 CCF33569.1 - 0.73 9.5 6.2 23 4.6 1.2 3.6 3 1 1 4 4 4 0 LMP repeated region DUF4337 PF14235.1 CCF33569.1 - 2.1 8.1 6.8 0.26 11.1 1.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) IncA PF04156.9 CCF33569.1 - 6.1 6.3 12.6 2.9 7.4 3.7 3.0 2 1 0 2 2 2 0 IncA protein Melibiase PF02065.13 CCF33570.1 - 2.4e-155 517.0 0.0 2.9e-155 516.8 0.0 1.1 1 0 0 1 1 1 1 Melibiase DUF187 PF02638.10 CCF33570.1 - 0.00023 20.1 0.0 0.00036 19.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase like GH101 AA_permease_2 PF13520.1 CCF33572.1 - 3.4e-63 213.6 46.9 4.1e-63 213.4 32.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF33572.1 - 5.7e-14 51.3 42.0 7.8e-14 50.8 29.1 1.1 1 0 0 1 1 1 1 Amino acid permease Sec1 PF00995.18 CCF33574.1 - 1.9e-141 472.5 0.0 2.1e-141 472.3 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Trs65 PF12735.2 CCF33575.1 - 1.9e-72 244.1 0.0 2.2e-72 243.9 0.0 1.0 1 0 0 1 1 1 1 TRAPP trafficking subunit Trs65 SLD3 PF08639.5 CCF33576.1 - 4.2e-114 381.9 0.2 4.2e-114 381.9 0.1 1.8 2 0 0 2 2 2 1 DNA replication regulator SLD3 Glyco_transf_8 PF01501.15 CCF33577.1 - 0.0015 17.9 0.2 0.0016 17.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 Nop16 PF09420.5 CCF33578.1 - 9.5e-55 185.1 3.2 1.1e-54 184.9 2.2 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 HTH_38 PF13936.1 CCF33578.1 - 0.022 14.2 2.5 0.58 9.7 1.7 2.4 1 1 0 1 1 1 0 Helix-turn-helix domain MARVEL PF01284.18 CCF33579.1 - 4e-08 33.1 9.2 6.7e-08 32.4 6.4 1.3 1 0 0 1 1 1 1 Membrane-associating domain DUF4281 PF14108.1 CCF33579.1 - 6.9e-05 22.9 0.6 0.00012 22.1 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4281) Init_tRNA_PT PF04179.7 CCF33580.1 - 2.8e-147 491.2 0.0 2.6e-146 488.0 0.0 1.9 1 1 0 1 1 1 1 Initiator tRNA phosphoribosyl transferase HIRA_B PF09453.5 CCF33580.1 - 1.2 8.8 2.8 4 7.1 0.2 2.5 2 0 0 2 2 2 0 HIRA B motif DUF1996 PF09362.5 CCF33581.1 - 2.1e-73 246.8 0.0 2.8e-73 246.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) DUF1774 PF08611.5 CCF33582.1 - 2.3e-33 114.2 1.2 2.3e-33 114.2 0.8 2.3 2 1 0 2 2 2 1 Fungal protein of unknown function (DUF1774) DUF1240 PF06836.7 CCF33582.1 - 7.7 6.8 10.4 1.6 9.0 0.1 3.3 1 1 3 4 4 4 0 Protein of unknown function (DUF1240) zf-RING_2 PF13639.1 CCF33583.1 - 4.6e-11 42.3 15.2 4.8e-11 42.2 9.0 2.0 2 0 0 2 2 2 1 Ring finger domain Helicase_C PF00271.26 CCF33583.1 - 1.2e-10 41.0 0.0 3e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.1 CCF33583.1 - 7e-10 38.7 16.6 1.8e-09 37.4 9.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF33583.1 - 7.4e-10 38.3 14.4 2.6e-09 36.5 8.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SNF2_N PF00176.18 CCF33583.1 - 7.8e-09 34.7 0.2 1.2e-08 34.1 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4 PF00097.20 CCF33583.1 - 1.4e-08 34.2 15.3 1.4e-08 34.2 10.6 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CCF33583.1 - 1.4e-08 34.4 7.5 4.3e-08 32.9 5.3 1.8 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 CCF33583.1 - 6.7e-07 28.9 12.9 6.7e-07 28.9 8.9 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.2 CCF33583.1 - 1.6e-05 24.8 11.8 7.5e-05 22.7 8.2 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_6 PF14835.1 CCF33583.1 - 2e-05 24.2 4.0 5.2e-05 22.9 2.8 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-Apc11 PF12861.2 CCF33583.1 - 0.0009 19.0 3.8 0.0019 17.9 2.7 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 CCF33583.1 - 0.0024 17.5 10.3 0.0024 17.5 7.2 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_4 PF14570.1 CCF33583.1 - 0.0085 15.6 7.4 0.019 14.5 5.1 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-Nse PF11789.3 CCF33583.1 - 0.012 15.1 8.4 0.026 14.0 5.8 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit TBCC PF07986.7 CCF33583.1 - 0.025 13.9 2.0 0.069 12.5 1.4 1.7 1 0 0 1 1 1 0 Tubulin binding cofactor C Phage_AlpA PF05930.7 CCF33583.1 - 0.1 12.3 0.0 0.24 11.1 0.0 1.7 1 0 0 1 1 1 0 Prophage CP4-57 regulatory protein (AlpA) DZR PF12773.2 CCF33583.1 - 1 9.2 7.2 2.8 7.8 5.0 1.7 1 1 0 1 1 1 0 Double zinc ribbon F-box PF00646.28 CCF33585.1 - 2.6e-09 36.5 0.1 3.7e-09 35.9 0.1 1.2 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 CCF33585.1 - 3.2e-08 33.1 0.1 5.2e-08 32.4 0.1 1.3 1 0 0 1 1 1 1 F-box-like F-box-like_2 PF13013.1 CCF33585.1 - 0.02 14.6 0.1 0.029 14.0 0.0 1.2 1 0 0 1 1 1 0 F-box-like domain PRANC PF09372.5 CCF33585.1 - 0.025 14.5 0.0 0.034 14.1 0.0 1.2 1 0 0 1 1 1 0 PRANC domain Peptidase_S10 PF00450.17 CCF33586.1 - 7.2e-131 437.1 1.0 9.2e-131 436.8 0.7 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.6 CCF33586.1 - 5e-06 26.6 0.1 9.2e-06 25.8 0.1 1.4 1 0 0 1 1 1 1 Carboxypeptidase Y pro-peptide Abhydrolase_6 PF12697.2 CCF33586.1 - 4.6e-05 23.4 0.0 0.00045 20.1 0.0 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase family SBDS_C PF09377.5 CCF33587.1 - 7.9e-51 170.9 0.0 1.2e-50 170.3 0.0 1.3 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.13 CCF33587.1 - 3e-30 103.8 0.4 4.9e-30 103.1 0.2 1.3 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Ribosomal_S13 PF00416.17 CCF33588.1 - 5.6e-40 136.1 1.6 6.7e-40 135.8 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.6 CCF33588.1 - 0.02 13.4 0.0 0.025 13.1 0.0 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) PP28 PF10252.4 CCF33588.1 - 0.056 13.4 0.6 0.11 12.4 0.4 1.5 1 0 0 1 1 1 0 Casein kinase substrate phosphoprotein PP28 Glu_synthase PF01645.12 CCF33590.1 - 1.5e-158 527.5 0.0 2.5e-158 526.8 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase GATase_2 PF00310.16 CCF33590.1 - 3.9e-139 463.3 0.0 5.2e-139 462.9 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_syn_central PF04898.9 CCF33590.1 - 3.5e-118 394.0 0.0 6.7e-118 393.1 0.0 1.4 1 0 0 1 1 1 1 Glutamate synthase central domain GXGXG PF01493.14 CCF33590.1 - 2.5e-70 235.6 2.7 4.5e-70 234.7 1.9 1.4 1 0 0 1 1 1 1 GXGXG motif Fer4_20 PF14691.1 CCF33590.1 - 1.6e-22 79.2 0.1 3.8e-22 77.9 0.1 1.7 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.9 CCF33590.1 - 1.2e-16 61.1 0.0 4.6e-16 59.3 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF33590.1 - 2.7e-11 43.8 0.2 4.5e-05 23.6 0.0 2.7 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF33590.1 - 9.5e-09 35.1 0.3 3.2e-08 33.4 0.0 2.1 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 CCF33590.1 - 1.2e-06 27.8 0.2 2.8e-06 26.6 0.1 1.6 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.22 CCF33590.1 - 1.4e-06 28.5 0.1 0.00023 21.4 0.0 3.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF33590.1 - 5.6e-05 22.2 0.2 5.6e-05 22.2 0.1 1.9 2 0 0 2 2 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 CCF33590.1 - 6.6e-05 21.5 0.1 6.6e-05 21.5 0.1 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.19 CCF33590.1 - 0.00036 19.4 2.6 0.00074 18.4 0.0 2.4 3 0 0 3 3 2 1 FAD binding domain FAD_oxidored PF12831.2 CCF33590.1 - 0.00042 19.5 0.0 0.00093 18.3 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 CCF33590.1 - 0.0006 18.9 0.0 0.0013 17.8 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.1 CCF33590.1 - 0.0012 19.0 0.4 0.43 10.8 0.1 2.9 2 0 0 2 2 2 1 Putative NAD(P)-binding AlaDh_PNT_C PF01262.16 CCF33590.1 - 0.0014 18.1 0.6 0.0038 16.7 0.0 1.9 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.12 CCF33590.1 - 0.0034 16.5 0.8 0.0087 15.1 0.0 2.0 2 0 0 2 2 2 1 Thi4 family NAD_Gly3P_dh_N PF01210.18 CCF33590.1 - 0.0041 16.8 0.0 0.0087 15.7 0.0 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GIDA PF01134.17 CCF33590.1 - 0.012 14.5 0.5 0.11 11.3 0.0 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A FMO-like PF00743.14 CCF33590.1 - 0.045 11.9 0.0 3 5.9 0.0 2.7 3 0 0 3 3 3 0 Flavin-binding monooxygenase-like Lycopene_cycl PF05834.7 CCF33590.1 - 0.062 12.2 0.1 4.5 6.0 0.1 2.6 3 0 0 3 3 3 0 Lycopene cyclase protein NAD_binding_9 PF13454.1 CCF33590.1 - 0.064 13.0 0.0 0.24 11.1 0.0 2.0 1 0 0 1 1 1 0 FAD-NAD(P)-binding DJ-1_PfpI PF01965.19 CCF33590.1 - 0.079 12.4 0.2 0.63 9.4 0.0 2.3 1 1 1 2 2 2 0 DJ-1/PfpI family Shikimate_DH PF01488.15 CCF33590.1 - 0.11 12.5 0.3 21 5.1 0.0 2.7 3 0 0 3 3 2 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 CCF33590.1 - 0.11 11.6 0.1 0.52 9.4 0.0 2.1 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FMN_dh PF01070.13 CCF33590.1 - 0.13 11.1 0.6 0.39 9.5 0.4 1.7 2 0 0 2 2 2 0 FMN-dependent dehydrogenase Glyco_transf_90 PF05686.7 CCF33591.1 - 1.2e-05 24.2 0.0 1.9e-05 23.5 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 90 zf-C2H2_jaz PF12171.3 CCF33592.1 - 0.0013 18.7 0.3 0.0063 16.6 0.2 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 CCF33592.1 - 0.0061 16.8 1.8 0.0061 16.8 1.2 4.1 4 0 0 4 4 4 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF33592.1 - 4.6 7.8 24.0 0.16 12.3 1.0 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger p450 PF00067.17 CCF33593.1 - 1.2e-09 37.2 0.0 1.5e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.11 CCF33595.1 - 9e-34 116.7 11.5 9e-34 116.7 8.0 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF3815 PF12821.2 CCF33596.1 - 1.1e-28 99.8 13.0 1.1e-28 99.8 9.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3815) DUF1212 PF06738.7 CCF33596.1 - 0.003 17.0 5.6 0.003 17.0 3.9 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF1212) DUF1282 PF06930.7 CCF33596.1 - 0.44 10.1 12.3 3.3 7.3 5.5 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1282) BTB PF00651.26 CCF33598.1 - 0.0093 15.9 0.3 0.049 13.6 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain CENP-T PF15511.1 CCF33598.1 - 0.04 13.1 6.2 0.053 12.7 4.3 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T bZIP_2 PF07716.10 CCF33600.1 - 7.1e-07 28.9 9.8 1.7e-06 27.7 6.8 1.7 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.16 CCF33600.1 - 1.7e-06 27.8 6.9 2.6e-06 27.2 4.8 1.3 1 0 0 1 1 1 1 bZIP transcription factor Mnd1 PF03962.10 CCF33600.1 - 0.0088 15.7 0.8 0.011 15.3 0.6 1.1 1 0 0 1 1 1 1 Mnd1 family Nop53 PF07767.6 CCF33600.1 - 0.031 13.2 2.9 0.036 13.0 2.0 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Phlebovirus_NSM PF07246.6 CCF33600.1 - 0.037 13.1 0.4 0.043 12.9 0.2 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M bZIP_Maf PF03131.12 CCF33600.1 - 0.041 14.1 5.3 0.073 13.3 3.6 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor MDFI PF15316.1 CCF33600.1 - 0.089 12.7 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 MyoD family inhibitor HpcH_HpaI PF03328.9 CCF33601.1 - 1.9e-26 92.3 1.3 3e-26 91.6 0.9 1.2 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family MFS_1 PF07690.11 CCF33602.1 - 1.4e-31 109.4 19.7 1.4e-31 109.4 13.6 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF33602.1 - 0.00047 19.8 1.2 0.00087 19.0 0.1 2.1 2 0 0 2 2 2 1 MFS_1 like family PsbJ PF01788.12 CCF33602.1 - 0.025 14.1 0.3 0.083 12.4 0.2 1.9 1 0 0 1 1 1 0 PsbJ Aminotran_1_2 PF00155.16 CCF33603.1 - 6e-16 58.3 0.0 8.8e-16 57.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.2 CCF33603.1 - 0.026 13.1 0.0 0.052 12.1 0.0 1.5 2 0 0 2 2 2 0 Alanine-glyoxylate amino-transferase Tannase PF07519.6 CCF33605.1 - 1.8e-91 307.2 0.0 2e-91 307.0 0.0 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_6 PF12697.2 CCF33605.1 - 1.9e-07 31.2 0.0 1.2e-06 28.5 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF33605.1 - 9.4e-05 21.7 0.1 0.064 12.4 0.1 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 CCF33605.1 - 0.00061 19.4 0.0 0.00081 19.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF33605.1 - 0.0017 18.0 0.1 0.69 9.6 0.1 2.4 2 0 0 2 2 2 2 Alpha/beta hydrolase family UbiA PF01040.13 CCF33607.1 - 1.9e-05 24.0 0.4 4.2e-05 22.8 0.1 1.7 1 1 0 1 1 1 1 UbiA prenyltransferase family DUF566 PF04484.7 CCF33607.1 - 8.2 5.8 15.0 12 5.3 10.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF566) SusD-like_2 PF12771.2 CCF33608.1 - 0.01 14.2 0.0 0.012 14.0 0.0 1.0 1 0 0 1 1 1 0 Starch-binding associating with outer membrane His_Phos_2 PF00328.17 CCF33609.1 - 2.1e-41 142.4 0.0 2.7e-41 142.0 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) TEBP_beta PF07404.6 CCF33610.1 - 0.064 12.3 6.0 0.077 12.1 4.1 1.1 1 0 0 1 1 1 0 Telomere-binding protein beta subunit (TEBP beta) Mucin PF01456.12 CCF33610.1 - 0.31 10.8 8.9 0.56 9.9 6.1 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein RNase_H2-Ydr279 PF09468.5 CCF33610.1 - 0.49 9.5 6.5 0.71 9.0 4.5 1.2 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Pex14_N PF04695.8 CCF33610.1 - 0.82 9.7 8.7 0.25 11.4 1.9 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1314 PF07013.6 CCF33610.1 - 4.8 6.5 5.8 1.6 8.0 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1314) Asp PF00026.18 CCF33611.1 - 5.9e-32 111.1 0.0 7.9e-32 110.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.1 CCF33611.1 - 0.015 15.7 0.0 6.3 7.3 0.0 2.8 2 1 0 2 2 2 0 Aspartyl protease DASH_Spc34 PF08657.5 CCF33612.1 - 0.00068 19.3 0.7 0.00086 19.0 0.5 1.3 1 0 0 1 1 1 1 DASH complex subunit Spc34 Tropomyosin_1 PF12718.2 CCF33612.1 - 0.0011 18.8 2.3 0.0014 18.4 1.6 1.1 1 0 0 1 1 1 1 Tropomyosin like Filament PF00038.16 CCF33612.1 - 0.0084 15.6 0.9 0.0094 15.4 0.6 1.2 1 0 0 1 1 1 1 Intermediate filament protein Tropomyosin PF00261.15 CCF33612.1 - 0.012 14.7 2.9 0.015 14.4 2.0 1.1 1 0 0 1 1 1 0 Tropomyosin DivIVA PF05103.8 CCF33612.1 - 0.013 15.5 1.5 0.019 15.0 1.0 1.2 1 0 0 1 1 1 0 DivIVA protein Med2 PF11214.3 CCF33612.1 - 0.016 15.2 0.2 0.023 14.7 0.2 1.2 1 0 0 1 1 1 0 Mediator complex subunit 2 DUF4200 PF13863.1 CCF33612.1 - 0.023 14.6 1.7 0.033 14.1 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) CENP-F_leu_zip PF10473.4 CCF33612.1 - 0.025 14.4 2.1 0.04 13.7 1.5 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF724 PF05266.9 CCF33612.1 - 0.026 14.1 0.5 0.031 13.9 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Allexi_40kDa PF05549.6 CCF33612.1 - 0.026 13.8 0.5 0.029 13.6 0.3 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein SGT1 PF07093.6 CCF33612.1 - 0.029 12.7 4.0 0.027 12.8 2.8 1.0 1 0 0 1 1 1 0 SGT1 protein Fibrinogen_BP PF08017.6 CCF33612.1 - 0.029 12.5 1.8 0.029 12.5 1.2 1.1 1 0 0 1 1 1 0 Fibrinogen binding protein Mnd1 PF03962.10 CCF33612.1 - 0.031 13.9 1.7 0.036 13.7 1.2 1.1 1 0 0 1 1 1 0 Mnd1 family SlyX PF04102.7 CCF33612.1 - 0.076 13.3 0.4 0.076 13.3 0.3 2.2 2 0 0 2 2 2 0 SlyX Peptidase_M61 PF05299.7 CCF33612.1 - 0.083 12.8 0.0 0.14 12.0 0.0 1.3 1 1 0 1 1 1 0 M61 glycyl aminopeptidase Bacillus_HBL PF05791.6 CCF33612.1 - 0.087 12.1 0.4 0.1 11.9 0.3 1.2 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Spc24 PF08286.6 CCF33612.1 - 0.088 12.5 2.0 0.12 12.1 1.4 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DUF2514 PF10721.4 CCF33612.1 - 0.09 12.4 4.6 0.11 12.2 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Viral_P18 PF04521.8 CCF33612.1 - 0.1 12.0 0.6 0.15 11.5 0.4 1.2 1 0 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein COG2 PF06148.6 CCF33612.1 - 0.11 12.3 0.3 0.14 12.0 0.2 1.1 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 NPV_P10 PF05531.7 CCF33612.1 - 0.14 12.3 0.4 0.22 11.7 0.3 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein IncA PF04156.9 CCF33612.1 - 0.28 10.7 1.5 0.34 10.4 1.0 1.2 1 0 0 1 1 1 0 IncA protein EAP30 PF04157.11 CCF33612.1 - 0.4 9.8 3.8 0.53 9.3 2.6 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family DivIC PF04977.10 CCF33612.1 - 3.6 7.1 6.6 1.1 8.7 2.6 1.6 2 0 0 2 2 2 0 Septum formation initiator DUF569 PF04601.8 CCF33614.1 - 0.072 12.5 0.0 0.085 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF569) AMP-binding PF00501.23 CCF33616.1 - 2.1e-73 247.1 0.0 4.2e-73 246.1 0.0 1.5 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF33616.1 - 1.2e-12 48.6 0.6 2e-12 47.8 0.1 1.7 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Peptidase_M50B PF13398.1 CCF33617.1 - 8.4e-56 188.5 18.1 1.2e-55 187.9 12.5 1.2 1 0 0 1 1 1 1 Peptidase M50B-like Peptidase_M50 PF02163.17 CCF33617.1 - 0.069 12.1 4.0 0.3 9.9 2.6 2.3 1 1 1 2 2 2 0 Peptidase family M50 ACR_tran PF00873.14 CCF33617.1 - 0.087 10.2 0.5 0.16 9.3 0.3 1.4 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Peptidase_M41 PF01434.13 CCF33617.1 - 0.13 11.7 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M41 Aa_trans PF01490.13 CCF33619.1 - 3.1e-10 39.1 4.7 3.5e-10 38.9 3.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF1449 PF07290.6 CCF33619.1 - 0.01 15.2 1.1 0.013 14.8 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1449) p450 PF00067.17 CCF33620.1 - 2.8e-70 237.1 0.0 3.6e-70 236.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RdRP PF05183.7 CCF33621.1 - 1.6e-158 529.0 0.0 2.3e-158 528.4 0.0 1.3 1 0 0 1 1 1 1 RNA dependent RNA polymerase DUF2884 PF11101.3 CCF33621.1 - 0.061 12.6 0.4 0.13 11.6 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) Abhydrolase_6 PF12697.2 CCF33622.1 - 1.5e-15 57.7 0.0 3.1e-15 56.6 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF33622.1 - 1.3e-08 34.6 0.0 2.3e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF33622.1 - 3.9e-05 23.4 0.0 0.00013 21.7 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family EthD PF07110.6 CCF33622.1 - 0.00013 22.8 0.1 0.24 12.3 0.0 2.6 2 0 0 2 2 2 2 EthD domain DUF4286 PF14114.1 CCF33622.1 - 0.0003 20.9 0.0 0.033 14.4 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4286) Ndr PF03096.9 CCF33622.1 - 0.006 15.1 0.0 0.01 14.3 0.0 1.3 1 0 0 1 1 1 1 Ndr family Esterase PF00756.15 CCF33622.1 - 0.056 12.8 0.0 0.095 12.1 0.0 1.3 1 0 0 1 1 1 0 Putative esterase P33MONOX PF15302.1 CCF33623.1 - 0.092 12.3 2.7 0.14 11.7 0.6 1.8 1 1 1 2 2 2 0 P33 mono-oxygenase DUF3622 PF12286.3 CCF33623.1 - 1.9 8.8 7.0 3.1 8.1 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3622) MPC PF03650.8 CCF33624.1 - 2.7e-41 140.2 0.8 3.6e-41 139.8 0.2 1.4 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0041) L51_S25_CI-B8 PF05047.11 CCF33625.1 - 1.4e-12 47.1 0.0 1.9e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain DASH_Dad2 PF08654.5 CCF33626.1 - 0.0005 20.0 1.1 0.0017 18.3 0.1 2.3 2 0 0 2 2 2 1 DASH complex subunit Dad2 GIDA PF01134.17 CCF33626.1 - 0.0042 15.9 1.0 0.0091 14.9 0.1 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A DUF148 PF02520.12 CCF33626.1 - 0.0059 16.3 2.4 0.027 14.2 0.2 2.9 2 0 0 2 2 2 1 Domain of unknown function DUF148 DivIC PF04977.10 CCF33626.1 - 0.0063 15.9 4.5 0.063 12.7 0.2 3.4 3 0 0 3 3 3 1 Septum formation initiator DUF2937 PF11157.3 CCF33626.1 - 0.027 13.8 1.6 0.14 11.4 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2937) DUF1664 PF07889.7 CCF33626.1 - 0.074 12.8 4.1 0.096 12.4 0.2 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) ApoLp-III PF07464.6 CCF33626.1 - 0.082 12.9 1.9 0.17 11.9 0.1 2.3 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) AAA_13 PF13166.1 CCF33626.1 - 0.12 10.8 5.8 0.3 9.4 0.5 2.2 2 0 0 2 2 2 0 AAA domain COG2 PF06148.6 CCF33626.1 - 0.14 12.0 9.5 5 7.0 2.0 4.4 2 1 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Baculo_PEP_C PF04513.7 CCF33626.1 - 0.28 10.9 7.5 17 5.2 0.8 3.6 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1395 PF07160.7 CCF33626.1 - 0.31 10.5 5.4 0.098 12.1 0.3 2.5 3 1 1 4 4 4 0 Protein of unknown function (DUF1395) Mnd1 PF03962.10 CCF33626.1 - 0.31 10.6 6.8 2.7 7.6 0.2 3.2 1 1 2 3 3 3 0 Mnd1 family FlgN PF05130.7 CCF33626.1 - 0.46 10.7 13.2 0.93 9.7 1.1 4.0 4 1 0 4 4 4 0 FlgN protein MutS_III PF05192.13 CCF33626.1 - 2.6 7.7 7.0 94 2.6 4.9 2.6 1 1 0 1 1 1 0 MutS domain III ING PF12998.2 CCF33626.1 - 4.8 7.4 8.2 6 7.1 0.1 3.4 4 0 0 4 4 4 0 Inhibitor of growth proteins N-terminal histone-binding DUF1664 PF07889.7 CCF33627.1 - 0.1 12.4 0.6 1.7 8.4 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) AA_permease_2 PF13520.1 CCF33628.1 - 8.2e-95 317.8 32.1 1e-94 317.4 22.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF33628.1 - 1.3e-23 83.1 28.7 1.7e-23 82.7 19.9 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3632 PF12311.3 CCF33630.1 - 4e-18 65.8 0.3 4e-18 65.8 0.2 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF3632) MFS_1 PF07690.11 CCF33631.1 - 2.3e-17 62.7 92.4 2.8e-15 55.8 35.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily GFA PF04828.9 CCF33632.1 - 1.3e-22 79.5 0.4 1.8e-22 79.0 0.3 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme NOB1_Zn_bind PF08772.6 CCF33632.1 - 0.28 11.0 4.4 0.47 10.3 0.0 2.2 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zf-ribbon_3 PF13248.1 CCF33632.1 - 0.45 9.7 0.1 0.45 9.7 0.0 2.4 3 0 0 3 3 3 0 zinc-ribbon domain Secretin_N_2 PF07655.8 CCF33633.1 - 0.066 13.6 5.4 0.11 12.8 3.8 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain DUF912 PF06024.7 CCF33633.1 - 0.82 9.7 3.7 1.4 8.9 2.6 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) KR PF08659.5 CCF33634.1 - 6e-56 188.9 0.1 1.4e-54 184.4 0.0 3.1 4 0 0 4 4 4 1 KR domain PS-DH PF14765.1 CCF33634.1 - 1.7e-52 178.4 0.0 2.9e-52 177.6 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.20 CCF33634.1 - 4.3e-42 143.8 0.3 1e-39 136.1 0.0 2.7 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N PF00107.21 CCF33634.1 - 6.7e-20 70.9 0.3 1.4e-18 66.7 0.1 2.8 3 0 0 3 3 3 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.7 CCF33634.1 - 2.8e-18 66.2 0.0 7e-18 64.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.1 CCF33634.1 - 4.8e-14 53.3 0.0 1.1e-12 48.9 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.1 CCF33634.1 - 4.7e-12 45.9 0.0 9.2e-12 44.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF33634.1 - 2e-08 34.6 0.0 5.8e-08 33.1 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF33634.1 - 3.6e-07 29.8 0.0 9.1e-07 28.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF33634.1 - 6.6e-07 29.9 0.0 2.4e-06 28.1 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF33634.1 - 3.3e-06 26.4 0.1 7.2e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PP-binding PF00550.20 CCF33634.1 - 0.00043 20.5 0.1 0.0011 19.2 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_16 PF10294.4 CCF33634.1 - 0.00085 18.8 0.0 0.0019 17.7 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase ADH_N PF08240.7 CCF33634.1 - 0.00088 19.0 0.0 0.0018 17.9 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain NAD_binding_10 PF13460.1 CCF33634.1 - 0.0013 18.8 0.2 0.28 11.1 0.1 3.0 3 0 0 3 3 3 1 NADH(P)-binding Acyl_transf_1 PF00698.16 CCF33634.1 - 0.019 14.2 0.0 0.031 13.5 0.0 1.3 1 0 0 1 1 1 0 Acyl transferase domain Saccharop_dh PF03435.13 CCF33634.1 - 0.02 13.8 0.0 0.19 10.6 0.0 2.2 2 0 0 2 2 2 0 Saccharopine dehydrogenase Methyltransf_8 PF05148.10 CCF33634.1 - 0.077 12.6 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Hypothetical methyltransferase Glyco_hydro_42M PF08532.5 CCF33634.1 - 0.09 11.9 0.0 0.4 9.7 0.0 2.0 2 0 0 2 2 2 0 Beta-galactosidase trimerisation domain PGM_PMM_I PF02878.11 CCF33635.1 - 3.9e-34 117.0 0.0 4.8e-34 116.7 0.0 1.1 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 CCF33635.1 - 0.0057 16.9 0.0 0.012 15.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II RNase_T PF00929.19 CCF33636.1 - 1.6e-20 73.9 0.0 2.1e-20 73.6 0.0 1.1 1 0 0 1 1 1 1 Exonuclease GFO_IDH_MocA PF01408.17 CCF33637.1 - 3.5e-12 46.8 0.0 1.1e-11 45.3 0.0 1.8 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 CCF33637.1 - 0.00057 19.6 0.1 0.0012 18.5 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain DUF3816 PF12822.2 CCF33638.1 - 0.01 15.7 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3816) DUF3336 PF11815.3 CCF33639.1 - 8.7e-36 122.5 0.1 2.6e-35 121.0 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Patatin PF01734.17 CCF33639.1 - 5.4e-14 52.5 0.2 1.6e-13 51.0 0.1 1.8 1 0 0 1 1 1 1 Patatin-like phospholipase Leo1 PF04004.8 CCF33640.1 - 8.7e-31 106.9 0.0 1.6e-30 106.0 0.0 1.4 1 0 0 1 1 1 1 Leo1-like protein tRNA_deacylase PF04414.7 CCF33640.1 - 0.15 11.1 0.0 0.24 10.4 0.0 1.3 1 0 0 1 1 1 0 D-aminoacyl-tRNA deacylase Epimerase PF01370.16 CCF33642.1 - 7.2e-21 74.6 0.0 1.2e-20 73.9 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF33642.1 - 5.8e-19 67.8 0.0 9.9e-19 67.1 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 CCF33642.1 - 4.6e-13 48.6 0.0 1.1e-12 47.3 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 CCF33642.1 - 6.4e-13 49.1 0.0 1.4e-12 47.9 0.0 1.6 1 1 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF33642.1 - 2.8e-06 26.7 0.0 0.00038 19.7 0.0 2.3 2 0 0 2 2 2 2 NmrA-like family KR PF08659.5 CCF33642.1 - 0.00013 21.6 0.2 0.00042 20.0 0.2 1.8 1 1 0 1 1 1 1 KR domain adh_short PF00106.20 CCF33642.1 - 0.00016 21.6 0.2 0.00073 19.4 0.1 2.1 2 1 0 2 2 2 1 short chain dehydrogenase Polysacc_synt_2 PF02719.10 CCF33642.1 - 0.0038 16.1 0.0 0.0067 15.3 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1996 PF09362.5 CCF33644.1 - 2.2e-55 187.9 0.4 2.7e-55 187.6 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) GFA PF04828.9 CCF33645.1 - 9.7e-15 54.2 2.4 1.5e-14 53.7 1.7 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Chromate_transp PF02417.10 CCF33647.1 - 5.3e-16 58.6 0.0 6.5e-16 58.3 0.0 1.1 1 0 0 1 1 1 1 Chromate transporter RabGAP-TBC PF00566.13 CCF33648.1 - 1.8e-27 96.2 0.0 3.5e-27 95.2 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DOCK-C2 PF14429.1 CCF33650.1 - 1.4e-24 86.7 0.0 2.2e-24 86.1 0.0 1.4 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins Ded_cyto PF06920.8 CCF33650.1 - 6.3e-09 35.3 0.6 2.2e-08 33.6 0.4 1.9 1 1 0 1 1 1 1 Dedicator of cytokinesis SH3_1 PF00018.23 CCF33650.1 - 7.4e-06 25.2 0.0 1.7e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 CCF33650.1 - 0.0012 18.3 0.0 0.0092 15.5 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain Sugar_tr PF00083.19 CCF33651.1 - 1.3e-39 136.0 5.6 1.5e-39 135.8 3.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF33651.1 - 3.4e-14 52.3 11.0 4.3e-14 51.9 7.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF33651.1 - 6.3e-07 28.1 0.2 1.4e-06 26.9 0.1 1.5 1 0 0 1 1 1 1 MFS/sugar transport protein Romo1 PF10247.4 CCF33651.1 - 0.079 13.1 0.8 0.23 11.6 0.6 1.8 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 Fungal_trans PF04082.13 CCF33652.1 - 2.3e-10 39.7 1.5 4e-10 38.9 0.2 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Herpes_UL95 PF03038.9 CCF33652.1 - 0.052 12.4 0.0 0.075 11.9 0.0 1.2 1 0 0 1 1 1 0 UL95 family MFS_1 PF07690.11 CCF33653.1 - 2.3e-28 98.9 37.0 2.3e-28 98.9 25.7 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily DIOX_N PF14226.1 CCF33654.1 - 6.5e-16 58.9 0.0 1.3e-15 57.9 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 CCF33654.1 - 0.0009 19.4 0.0 0.0017 18.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-C3HC4 PF00097.20 CCF33655.1 - 7.3e-07 28.7 7.6 4.4e-06 26.2 5.7 1.9 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF33655.1 - 1.3e-06 28.0 10.4 2.3e-06 27.2 7.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 CCF33655.1 - 1.5e-06 27.7 10.0 3.3e-06 26.7 6.9 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CCF33655.1 - 3.7e-06 26.8 10.6 6.9e-06 25.9 7.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF33655.1 - 1.9e-05 24.2 8.3 3.3e-05 23.4 5.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CCF33655.1 - 3.6e-05 23.5 7.1 4.7e-05 23.1 4.1 1.9 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 CCF33655.1 - 0.014 15.0 8.3 0.035 13.8 3.7 2.5 2 0 0 2 2 2 0 RING-type zinc-finger FYVE PF01363.16 CCF33655.1 - 0.087 12.7 4.8 0.17 11.7 3.3 1.5 1 0 0 1 1 1 0 FYVE zinc finger zf-4CXXC_R1 PF10497.4 CCF33655.1 - 0.09 12.9 1.6 0.15 12.1 1.1 1.4 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-RING_4 PF14570.1 CCF33655.1 - 0.61 9.7 8.8 1.6 8.3 5.7 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.2 CCF33655.1 - 2.5 8.2 8.6 6.4 6.9 5.9 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger DUF747 PF05346.6 CCF33656.1 - 1.4e-130 435.2 9.3 1.7e-130 434.9 6.4 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family DLH PF01738.13 CCF33657.1 - 1.7e-28 99.3 0.0 2e-28 99.1 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 CCF33657.1 - 9.2e-07 28.7 0.0 1.4e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF33657.1 - 0.011 15.6 0.0 0.14 12.0 0.0 2.0 1 1 0 2 2 2 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF33657.1 - 0.018 14.2 0.0 0.044 12.9 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family BAAT_C PF08840.6 CCF33657.1 - 0.082 12.5 0.7 5 6.7 0.0 2.4 3 0 0 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal Siah-Interact_N PF09032.6 CCF33658.1 - 0.034 14.2 0.2 0.12 12.4 0.1 1.9 1 0 0 1 1 1 0 Siah interacting protein, N terminal Latrophilin PF02354.11 CCF33658.1 - 0.039 12.6 0.0 0.061 12.0 0.0 1.2 1 0 0 1 1 1 0 Latrophilin Cytoplasmic C-terminal region p450 PF00067.17 CCF33660.1 - 6.1e-20 71.1 0.0 1.4e-19 69.9 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 BTB PF00651.26 CCF33661.1 - 0.004 17.1 0.0 0.0084 16.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Adeno_E1A PF02703.9 CCF33661.1 - 0.046 13.1 0.0 0.071 12.5 0.0 1.2 1 0 0 1 1 1 0 Early E1A protein LETM1 PF07766.8 CCF33662.1 - 5.2e-08 32.2 1.1 3.3e-07 29.6 0.2 2.0 2 0 0 2 2 2 1 LETM1-like protein DLH PF01738.13 CCF33663.1 - 3.5e-15 55.8 0.0 5e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 CCF33663.1 - 1.6e-07 31.2 0.1 2e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF33663.1 - 2.6e-07 30.7 0.7 0.0024 17.7 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 CCF33663.1 - 0.0038 16.8 0.9 0.054 13.0 0.0 2.0 1 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 CCF33663.1 - 0.0064 15.9 0.0 0.0079 15.6 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase BAAT_C PF08840.6 CCF33663.1 - 0.0068 16.1 0.0 0.86 9.2 0.0 2.1 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Tcell_CD4_Cterm PF12104.3 CCF33663.1 - 0.064 12.8 0.4 0.16 11.6 0.2 1.6 1 0 0 1 1 1 0 T cell CD4 receptor C terminal region SNF2_N PF00176.18 CCF33664.1 - 3.8e-18 65.3 0.0 5.4e-17 61.5 0.0 2.2 1 1 0 1 1 1 1 SNF2 family N-terminal domain DNA_methylase PF00145.12 CCF33664.1 - 5.2e-14 52.1 0.0 1.2e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase zf-C3HC4 PF00097.20 CCF33664.1 - 0.0022 17.6 8.3 0.0061 16.1 5.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CCF33664.1 - 0.055 13.3 2.1 0.22 11.4 1.4 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.1 CCF33664.1 - 0.059 12.9 6.8 0.15 11.6 4.7 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain SF3a60_bindingd PF12108.3 CCF33665.1 - 1.9e-09 36.8 0.2 4.3e-09 35.7 0.1 1.6 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-met PF12874.2 CCF33665.1 - 3.7e-07 30.1 0.2 6.7e-07 29.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 CCF33665.1 - 6.2e-07 29.3 0.2 1.2e-06 28.5 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 CCF33665.1 - 0.02 14.9 0.1 0.064 13.3 0.1 1.8 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Myb_CC_LHEQLE PF14379.1 CCF33665.1 - 0.23 11.0 2.2 0.56 9.8 1.6 1.7 1 0 0 1 1 1 0 MYB-CC type transfactor, LHEQLE motif DEAD PF00270.24 CCF33666.1 - 2.4e-40 137.7 0.3 6.3e-40 136.4 0.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF33666.1 - 4.4e-29 100.1 0.2 9.1e-29 99.1 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.1 CCF33666.1 - 0.014 15.0 0.6 0.032 13.8 0.4 1.6 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 CCF33666.1 - 0.019 14.6 0.2 0.049 13.4 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain ResIII PF04851.10 CCF33666.1 - 0.036 13.9 0.1 0.079 12.7 0.1 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.9 CCF33666.1 - 0.045 13.5 0.2 0.15 11.8 0.0 2.0 2 1 0 2 2 2 0 Flavivirus DEAD domain AAA_22 PF13401.1 CCF33666.1 - 0.096 12.8 0.7 0.43 10.7 0.5 2.0 1 1 0 1 1 1 0 AAA domain DUF373 PF04123.8 CCF33667.1 - 5.5 5.9 10.8 1.4 7.8 4.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF373) F-box-like PF12937.2 CCF33669.1 - 4.6e-08 32.6 0.0 9.1e-08 31.7 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF33669.1 - 7.6e-06 25.4 0.1 1.9e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 F-box domain 4HBT PF03061.17 CCF33670.1 - 6.2e-13 48.6 0.0 8.4e-13 48.2 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.1 CCF33670.1 - 8.8e-06 25.6 0.1 2.1e-05 24.4 0.0 1.6 1 1 1 2 2 2 1 Thioesterase-like superfamily Pex2_Pex12 PF04757.9 CCF33671.1 - 1.2e-55 188.3 3.6 1.6e-55 187.9 2.5 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.1 CCF33671.1 - 2.1e-05 24.4 3.0 3.8e-05 23.6 2.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CCF33671.1 - 0.00027 20.7 3.1 0.00048 19.9 2.2 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.1 CCF33671.1 - 0.00063 19.5 2.0 0.00099 18.8 1.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 CCF33671.1 - 0.098 12.3 2.6 0.17 11.5 1.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF33671.1 - 0.11 12.1 1.2 0.17 11.5 0.8 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Glyco_hydro_16 PF00722.16 CCF33672.1 - 3.9e-08 32.8 0.0 1.7e-07 30.7 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Peptidase_M13_N PF05649.8 CCF33674.1 - 1.9e-92 310.3 0.0 7.2e-92 308.4 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M13 Peptidase_M13 PF01431.16 CCF33674.1 - 4e-58 196.0 0.4 1.1e-57 194.5 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M13 NPCC PF08058.6 CCF33675.1 - 0.11 12.3 2.5 0.24 11.2 0.9 2.2 1 1 1 2 2 2 0 Nuclear pore complex component CAP_N PF01213.14 CCF33676.1 - 0.29 10.3 4.4 0.33 10.2 3.1 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Gag_p15 PF08723.5 CCF33677.1 - 0.14 12.1 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Gag protein p15 Na_Ca_ex PF01699.19 CCF33678.1 - 1.5e-23 82.9 24.9 1.4e-14 53.9 5.1 2.9 2 1 0 2 2 2 2 Sodium/calcium exchanger protein MLANA PF14991.1 CCF33678.1 - 3.1 7.8 4.4 4.6 7.2 0.0 3.1 3 1 1 4 4 4 0 Protein melan-A ATE_C PF04377.10 CCF33679.1 - 4.2e-42 143.2 0.5 1.8e-41 141.1 0.1 2.1 2 0 0 2 2 2 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.8 CCF33679.1 - 2.8e-15 55.8 1.6 3.5e-15 55.5 0.2 1.8 2 0 0 2 2 2 1 Arginine-tRNA-protein transferase, N terminus Acetyltransf_6 PF13480.1 CCF33679.1 - 0.076 12.9 3.7 0.099 12.5 0.2 2.8 4 0 0 4 4 4 0 Acetyltransferase (GNAT) domain Methyltransf_23 PF13489.1 CCF33680.1 - 6.1e-19 68.3 0.1 9.1e-19 67.7 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF33680.1 - 2.5e-09 37.4 0.0 1.3e-08 35.2 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF33680.1 - 3.9e-08 33.8 0.0 1.9e-07 31.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF33680.1 - 4.4e-08 33.4 0.0 3.9e-07 30.4 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF33680.1 - 2.1e-07 30.6 0.0 0.00023 20.8 0.0 2.4 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_25 PF13649.1 CCF33680.1 - 1.9e-05 24.9 0.0 6.2e-05 23.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF33680.1 - 0.00081 18.5 0.0 0.44 9.6 0.0 2.2 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 CCF33680.1 - 0.0011 19.0 0.0 0.0047 16.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF33680.1 - 0.0016 17.5 0.0 0.0024 16.9 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 CCF33680.1 - 0.0035 16.7 0.0 0.011 15.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_16 PF10294.4 CCF33680.1 - 0.0084 15.5 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.8 CCF33680.1 - 0.013 14.6 0.0 0.024 13.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.14 CCF33680.1 - 0.074 13.0 0.0 0.19 11.7 0.0 1.6 2 0 0 2 2 2 0 FtsJ-like methyltransferase DUF938 PF06080.7 CCF33680.1 - 0.095 12.2 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Arylsulfotran_2 PF14269.1 CCF33681.1 - 2.7e-46 158.0 0.0 3.8e-46 157.5 0.0 1.1 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.6 CCF33681.1 - 1.3e-20 73.3 0.0 4.5e-19 68.3 0.0 2.1 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) PQQ_2 PF13360.1 CCF33681.1 - 0.056 12.9 0.0 0.15 11.4 0.0 1.8 1 1 0 1 1 1 0 PQQ-like domain DUF1517 PF07466.6 CCF33682.1 - 0.03 13.3 1.5 0.065 12.2 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) DUF4131 PF13567.1 CCF33682.1 - 0.038 13.3 0.0 0.093 12.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) TILa PF12714.2 CCF33682.1 - 7 6.5 19.4 0.43 10.3 3.2 3.1 2 1 0 2 2 2 0 TILa domain V-ATPase_H_N PF03224.9 CCF33683.1 - 2e-72 243.9 0.0 2.8e-72 243.4 0.0 1.2 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.3 CCF33683.1 - 5.3e-39 132.8 0.1 2e-38 130.9 0.0 2.0 2 0 0 2 2 2 1 V-ATPase subunit H UNC45-central PF11701.3 CCF33683.1 - 0.035 13.7 0.0 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central HEAT_2 PF13646.1 CCF33683.1 - 0.14 12.5 2.4 4 7.7 0.0 3.3 3 1 0 3 3 3 0 HEAT repeats Ribul_P_3_epim PF00834.14 CCF33684.1 - 3.8e-61 205.6 0.0 2.1e-60 203.3 0.0 1.9 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.14 CCF33684.1 - 0.01 15.3 0.0 0.018 14.5 0.0 1.4 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain OMPdecase PF00215.19 CCF33684.1 - 0.018 14.4 0.4 0.033 13.5 0.0 1.6 2 0 0 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family ThiG PF05690.9 CCF33684.1 - 0.027 13.5 0.2 0.04 12.9 0.1 1.2 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG Pro_dh PF01619.13 CCF33687.1 - 3.9e-37 127.8 0.0 9.6e-37 126.6 0.0 1.5 2 0 0 2 2 2 1 Proline dehydrogenase DUF2156 PF09924.4 CCF33687.1 - 0.093 11.5 0.1 4.3 6.0 0.0 2.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2156) Flavin_Reduct PF01613.13 CCF33688.1 - 4.8e-11 42.7 0.0 6.4e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain SET PF00856.23 CCF33689.1 - 1.7e-20 73.9 0.8 1.7e-20 73.9 0.6 2.6 2 0 0 2 2 2 1 SET domain CRAL_TRIO PF00650.15 CCF33691.1 - 1.9e-13 50.1 0.0 2.7e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain DUF2167 PF09935.4 CCF33691.1 - 0.025 13.4 0.3 0.041 12.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2167) CRAL_TRIO_N PF03765.10 CCF33691.1 - 0.034 14.2 0.0 0.08 13.0 0.0 1.7 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain RRM_6 PF14259.1 CCF33692.1 - 1.9e-06 27.7 0.0 4.1e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF33692.1 - 0.0014 18.4 0.0 0.0031 17.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CCF33692.1 - 0.051 13.2 0.1 0.12 12.0 0.1 1.7 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HPIH PF13323.1 CCF33693.1 - 3.5e-30 104.7 1.0 4.2e-30 104.4 0.7 1.1 1 0 0 1 1 1 1 N-terminal domain with HPIH motif DUF4533 PF15047.1 CCF33693.1 - 0.055 12.8 0.1 0.07 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4533) Isochorismatase PF00857.15 CCF33694.1 - 5.8e-27 94.7 0.1 9.1e-27 94.0 0.0 1.3 1 1 0 1 1 1 1 Isochorismatase family S1-P1_nuclease PF02265.11 CCF33695.1 - 3.5e-16 59.5 0.3 3.9e-16 59.4 0.2 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease DUF1318 PF07027.7 CCF33695.1 - 0.11 12.8 0.0 0.11 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1318) RPAP1_C PF08620.5 CCF33696.1 - 6.6e-29 99.5 0.0 1.2e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.5 CCF33696.1 - 3.6e-15 55.2 6.3 3.6e-15 55.2 4.4 1.9 2 0 0 2 2 2 1 RPAP1-like, N-terminal Rubella_E1 PF05748.6 CCF33698.1 - 0.092 11.3 0.0 0.11 11.1 0.0 1.0 1 0 0 1 1 1 0 Rubella membrane glycoprotein E1 Cutinase PF01083.17 CCF33699.1 - 2.8e-39 134.6 0.7 3.2e-39 134.4 0.5 1.0 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.6 CCF33699.1 - 7.2e-05 22.3 0.0 0.00011 21.7 0.0 1.3 1 0 0 1 1 1 1 PE-PPE domain Abhydrolase_5 PF12695.2 CCF33699.1 - 0.005 16.5 0.0 0.0054 16.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF33699.1 - 0.047 13.5 0.0 0.055 13.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF3089 PF11288.3 CCF33699.1 - 0.05 12.7 0.0 0.068 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Abhydrolase_2 PF02230.11 CCF33699.1 - 0.09 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase PE PF00934.15 CCF33700.1 - 0.012 15.6 0.6 0.022 14.8 0.4 1.4 1 0 0 1 1 1 0 PE family ATP-synt_B PF00430.13 CCF33700.1 - 0.015 15.1 0.7 0.015 15.1 0.5 1.5 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) Velvet PF11754.3 CCF33701.1 - 5.1e-53 179.7 0.0 8.5e-53 178.9 0.0 1.3 1 0 0 1 1 1 1 Velvet factor EF-hand_7 PF13499.1 CCF33702.1 - 0.018 15.1 0.0 0.039 14.0 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair Dynamin_N PF00350.18 CCF33702.1 - 0.086 12.6 0.1 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Dynamin family KfrA_N PF11740.3 CCF33702.1 - 0.17 12.3 0.0 0.17 12.3 0.0 2.2 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term Pkinase PF00069.20 CCF33703.1 - 3.4e-22 78.8 0.0 1e-10 41.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CCF33703.1 - 5.1e-08 32.3 0.0 0.0002 20.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Cpn60_TCP1 PF00118.19 CCF33703.1 - 0.044 12.4 0.0 0.065 11.8 0.0 1.1 1 0 0 1 1 1 0 TCP-1/cpn60 chaperonin family p450 PF00067.17 CCF33704.1 - 1.3e-54 185.5 0.0 1.8e-54 185.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 TPR_11 PF13414.1 CCF33707.1 - 2.8e-14 52.5 2.1 1.9e-07 30.6 0.2 4.5 2 2 1 4 4 4 2 TPR repeat TPR_14 PF13428.1 CCF33707.1 - 1.6e-11 43.7 3.4 0.00015 22.0 0.4 5.4 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.1 CCF33707.1 - 6e-11 42.5 2.5 3.6e-07 30.4 0.2 3.5 2 2 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 CCF33707.1 - 3.6e-10 40.2 3.6 1.5e-05 25.5 0.2 3.9 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 CCF33707.1 - 6.8e-08 31.8 4.2 7.5e-05 22.3 0.2 4.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.1 CCF33707.1 - 6.7e-07 29.0 0.3 0.0011 18.9 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.1 CCF33707.1 - 1.9e-06 27.6 0.7 0.00012 21.8 0.0 2.7 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 CCF33707.1 - 1.9e-06 27.2 0.1 0.0027 17.3 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 CCF33707.1 - 7.4e-06 25.3 1.4 0.0003 20.2 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 CCF33707.1 - 1.2e-05 25.1 2.9 0.024 14.5 0.1 3.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_20 PF14561.1 CCF33707.1 - 4.2e-05 23.5 1.8 0.0027 17.7 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat FAT PF02259.18 CCF33707.1 - 0.00054 19.0 0.1 0.0008 18.4 0.0 1.4 1 0 0 1 1 1 1 FAT domain TPR_6 PF13174.1 CCF33707.1 - 0.00071 19.8 1.7 1.4 9.4 0.1 4.2 5 0 0 5 5 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 CCF33707.1 - 0.0012 18.5 1.3 0.039 13.7 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 CCF33707.1 - 0.0033 17.5 0.1 0.02 15.0 0.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.12 CCF33707.1 - 0.0093 16.2 1.4 1.5 9.0 0.0 3.1 3 0 0 3 3 3 1 Bacterial transcriptional activator domain PPR_3 PF13812.1 CCF33707.1 - 0.012 15.8 0.1 0.058 13.6 0.0 2.3 2 0 0 2 2 1 0 Pentatricopeptide repeat domain ChAPs PF09295.5 CCF33707.1 - 0.021 13.6 0.1 0.028 13.1 0.0 1.2 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) Methyltransf_1N PF02870.10 CCF33707.1 - 0.035 14.6 0.1 0.17 12.5 0.0 2.2 2 0 0 2 2 2 0 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain MUG2_C PF08593.5 CCF33707.1 - 0.13 12.4 0.3 0.34 11.1 0.2 1.7 1 0 0 1 1 1 0 Meiotically up-regulated glycoproteins C-terminal Methyltransf_12 PF08242.7 CCF33708.1 - 2.2e-14 53.6 0.1 6.8e-14 52.1 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF33708.1 - 2.2e-10 40.4 0.0 5.3e-10 39.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF33708.1 - 7.5e-10 39.3 0.0 1.7e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF33708.1 - 8e-10 39.0 0.0 1.8e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF33708.1 - 1.8e-09 37.8 0.0 2.8e-08 34.0 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF33708.1 - 1.2e-07 31.4 0.0 1.9e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF33708.1 - 2.7e-06 26.6 0.0 4.3e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 CCF33708.1 - 5.7e-05 23.1 0.0 0.00011 22.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.1 CCF33708.1 - 9.4e-05 23.2 0.0 0.00026 21.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF33708.1 - 0.00019 20.8 0.0 0.00031 20.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain DUF3419 PF11899.3 CCF33708.1 - 0.00023 20.0 0.0 0.00034 19.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_8 PF05148.10 CCF33708.1 - 0.00089 18.9 0.0 0.035 13.7 0.0 2.3 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_32 PF13679.1 CCF33708.1 - 0.017 14.7 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 CCF33708.1 - 0.029 13.3 0.0 3.4 6.5 0.0 2.3 1 1 1 2 2 2 0 NNMT/PNMT/TEMT family FmrO PF07091.6 CCF33708.1 - 0.056 12.4 0.0 0.078 11.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Methyltransf_16 PF10294.4 CCF33708.1 - 0.072 12.5 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase RrnaAD PF00398.15 CCF33708.1 - 0.086 11.8 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Y_phosphatase3 PF13350.1 CCF33709.1 - 1.9e-21 77.0 0.4 9e-20 71.5 0.2 2.6 1 1 1 2 2 2 1 Tyrosine phosphatase family Y_phosphatase3C PF13348.1 CCF33709.1 - 1.7e-06 28.0 0.1 4.4e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 Tyrosine phosphatase family C-terminal region Y_phosphatase2 PF03162.8 CCF33709.1 - 1.1e-05 24.9 0.0 2e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.15 CCF33709.1 - 0.00048 19.7 0.0 0.66 9.5 0.0 2.4 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 CCF33709.1 - 0.0034 16.7 0.0 0.0049 16.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.9 CCF33709.1 - 0.05 12.3 0.0 0.072 11.8 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain MFS_1 PF07690.11 CCF33710.1 - 9.9e-47 159.3 37.4 9.9e-47 159.3 25.9 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF33710.1 - 4.4e-12 45.3 24.7 6.2e-12 44.8 17.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_3 PF05977.8 CCF33710.1 - 9.2e-05 20.7 1.1 0.00015 20.0 0.8 1.3 1 0 0 1 1 1 1 Transmembrane secretion effector OATP PF03137.15 CCF33710.1 - 1 7.3 18.8 0.72 7.8 5.7 3.6 1 1 2 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family p450 PF00067.17 CCF33711.1 - 1.1e-51 175.8 0.0 1.5e-51 175.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Chitin_synth_1 PF01644.12 CCF33712.1 - 7.9e-83 276.1 0.1 1.3e-82 275.4 0.1 1.4 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 CCF33712.1 - 2.4e-32 110.4 0.1 5.6e-32 109.2 0.1 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 CCF33712.1 - 1.9e-21 76.0 3.8 2.7e-19 68.9 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.1 CCF33712.1 - 1e-09 38.3 0.3 1e-09 38.3 0.2 2.3 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 CCF33712.1 - 8e-07 29.0 0.0 2.1e-06 27.7 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 DUF1361 PF07099.6 CCF33712.1 - 0.0021 17.9 3.4 0.0021 17.9 2.4 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1361) DUF4551 PF15087.1 CCF33712.1 - 2.3 6.5 3.7 3.4 5.9 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) ABC_tran PF00005.22 CCF33713.1 - 9.3e-23 81.0 0.0 8.5e-10 39.0 0.0 3.7 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 CCF33713.1 - 1.1e-10 41.9 0.1 0.0098 15.8 0.1 4.1 4 0 0 4 4 4 2 AAA domain SbcCD_C PF13558.1 CCF33713.1 - 6.3e-08 32.4 0.0 0.00078 19.3 0.0 2.4 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_17 PF13207.1 CCF33713.1 - 2.1e-07 31.7 0.0 0.026 15.3 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.1 CCF33713.1 - 2.5e-05 24.4 0.0 0.64 10.1 0.0 3.4 4 0 0 4 4 3 2 AAA domain AAA_29 PF13555.1 CCF33713.1 - 5.8e-05 22.5 0.0 0.19 11.2 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.1 CCF33713.1 - 0.00046 20.5 0.1 0.37 11.1 0.1 2.2 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 CCF33713.1 - 0.00083 18.8 0.2 1.5 8.1 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.1 CCF33713.1 - 0.002 18.0 0.0 2 8.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.1 CCF33713.1 - 0.0036 17.1 0.0 0.61 9.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CCF33713.1 - 0.0042 17.0 2.7 1.8 8.4 0.4 3.1 2 2 0 2 2 2 2 AAA ATPase domain Miro PF08477.8 CCF33713.1 - 0.0054 17.2 0.0 0.75 10.3 0.0 2.4 2 0 0 2 2 2 1 Miro-like protein MobB PF03205.9 CCF33713.1 - 0.01 15.5 0.0 6 6.5 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 CCF33713.1 - 0.011 16.0 0.1 6.7 7.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 CCF33713.1 - 0.014 14.9 0.0 0.11 11.9 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_10 PF12846.2 CCF33713.1 - 0.014 14.8 0.4 5.1 6.4 0.0 2.7 4 0 0 4 4 2 0 AAA-like domain AAA_28 PF13521.1 CCF33713.1 - 0.023 14.6 0.0 8.4 6.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 CCF33713.1 - 0.043 13.9 0.0 2 8.6 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA PF00004.24 CCF33713.1 - 0.049 13.8 0.1 1.2 9.3 0.0 2.9 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 CCF33713.1 - 0.082 12.0 0.0 4.2 6.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 SRPRB PF09439.5 CCF33713.1 - 0.096 11.8 0.0 2.8 7.1 0.0 2.1 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit NACHT PF05729.7 CCF33713.1 - 0.13 11.9 0.0 18 4.9 0.0 2.9 3 0 0 3 3 2 0 NACHT domain FtsK_SpoIIIE PF01580.13 CCF33713.1 - 0.15 11.4 0.0 11 5.4 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_24 PF13479.1 CCF33713.1 - 0.17 11.4 0.0 6 6.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.12 CCF33713.1 - 0.23 10.9 0.0 2.8 7.4 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Arch_ATPase PF01637.13 CCF33713.1 - 0.28 10.8 0.0 22 4.6 0.0 2.3 2 0 0 2 2 2 0 Archaeal ATPase AAA_13 PF13166.1 CCF33713.1 - 0.46 8.8 0.2 0.79 8.1 0.0 1.3 2 0 0 2 2 2 0 AAA domain p450 PF00067.17 CCF33715.1 - 7.8e-37 126.8 0.0 9.7e-37 126.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 CCF33716.1 - 1.2e-34 119.6 0.0 8.5e-31 106.9 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 p450 PF00067.17 CCF33717.1 - 3e-37 128.2 0.1 2.9e-24 85.4 0.0 2.3 2 1 0 2 2 2 2 Cytochrome P450 MBOAT_2 PF13813.1 CCF33717.1 - 4.4e-22 77.9 2.0 1.1e-21 76.6 1.4 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family DUF4418 PF14387.1 CCF33717.1 - 0.067 12.9 0.7 0.15 11.8 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4418) ERG4_ERG24 PF01222.12 CCF33718.1 - 6.2e-91 305.0 9.6 7.2e-91 304.8 6.7 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 CCF33718.1 - 3.8e-06 26.3 1.2 8.8e-06 25.1 0.2 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF1295) ICMT PF04140.9 CCF33718.1 - 0.0016 18.6 0.1 0.0069 16.5 0.0 2.1 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 CCF33718.1 - 0.019 15.0 5.8 0.023 14.7 0.0 3.1 3 0 0 3 3 3 0 Phospholipid methyltransferase adh_short PF00106.20 CCF33719.1 - 7.9e-16 58.4 0.0 1.2e-15 57.7 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF33719.1 - 1.3e-08 34.7 0.0 2e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF33719.1 - 0.033 13.6 0.0 0.079 12.3 0.0 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 CCF33719.1 - 0.077 11.8 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein MAPEG PF01124.13 CCF33720.1 - 7.7e-18 64.3 0.3 8.3e-18 64.2 0.2 1.1 1 0 0 1 1 1 1 MAPEG family TOMM6 PF15184.1 CCF33720.1 - 0.096 12.0 0.0 0.18 11.1 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial import receptor subunit TOM6 homolog Glyoxalase PF00903.20 CCF33721.1 - 1.7e-08 34.4 0.0 2.4e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 CCF33721.1 - 1.3e-05 25.7 0.0 2.1e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase-like domain AAA PF00004.24 CCF33722.1 - 5.1e-17 62.2 0.0 8.8e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CCF33722.1 - 0.00042 20.4 0.0 0.0019 18.3 0.0 1.9 1 1 1 2 2 2 1 AAA domain Zot PF05707.7 CCF33722.1 - 0.0012 18.4 0.1 0.027 13.9 0.0 2.4 1 1 0 1 1 1 1 Zonular occludens toxin (Zot) AAA_5 PF07728.9 CCF33722.1 - 0.0013 18.4 0.0 0.0028 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 CCF33722.1 - 0.0017 18.6 0.0 0.0065 16.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 CCF33722.1 - 0.0027 18.5 0.0 0.013 16.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CCF33722.1 - 0.0031 17.5 0.0 0.0095 15.9 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 CCF33722.1 - 0.0036 17.0 0.2 0.008 15.9 0.2 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_2 PF07724.9 CCF33722.1 - 0.0075 16.1 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_30 PF13604.1 CCF33722.1 - 0.015 14.8 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 CCF33722.1 - 0.058 12.9 0.3 0.21 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 CCF33722.1 - 0.074 12.9 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 CCF33722.1 - 0.13 11.7 1.3 0.22 10.9 0.0 2.0 2 1 0 2 2 2 0 AAA domain BTB PF00651.26 CCF33723.1 - 0.023 14.6 0.0 0.077 12.9 0.0 1.8 2 0 0 2 2 2 0 BTB/POZ domain PGA2 PF07543.7 CCF33724.1 - 0.055 13.2 1.4 0.084 12.6 0.9 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 DUF2946 PF11162.3 CCF33725.1 - 0.041 14.0 1.0 0.053 13.7 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) Methyltransf_23 PF13489.1 CCF33727.1 - 1.8e-11 44.0 0.0 3.1e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF33727.1 - 1.4e-06 28.7 0.0 7.3e-06 26.3 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF33727.1 - 0.0023 18.3 0.0 0.0053 17.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF33727.1 - 0.0062 16.1 0.0 0.0081 15.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF33727.1 - 0.0068 16.4 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF33727.1 - 0.02 15.4 0.0 0.15 12.6 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.13 CCF33727.1 - 0.14 11.2 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 CCF33727.1 - 0.16 12.3 0.0 0.33 11.3 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Ldh_2 PF02615.9 CCF33728.1 - 1.2e-81 274.0 0.0 1.4e-81 273.8 0.0 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase Pkinase PF00069.20 CCF33729.1 - 4.2e-63 212.9 0.9 7e-63 212.1 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF33729.1 - 1.3e-35 122.7 0.0 2.7e-35 121.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.11 CCF33729.1 - 2.8e-26 91.0 21.3 1.7e-16 59.7 2.9 2.8 3 0 0 3 3 3 2 Hr1 repeat C1_1 PF00130.17 CCF33729.1 - 1.4e-19 69.5 31.5 2.2e-11 43.3 7.9 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.19 CCF33729.1 - 4.2e-14 52.7 3.0 1.3e-13 51.2 2.1 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain DUF605 PF04652.11 CCF33729.1 - 4.3 6.6 36.0 0.051 12.9 17.8 2.5 2 0 0 2 2 2 0 Vta1 like OSCP PF00213.13 CCF33730.1 - 0.11 12.3 0.3 0.27 11.1 0.2 1.7 1 1 0 1 1 1 0 ATP synthase delta (OSCP) subunit DUF935 PF06074.7 CCF33730.1 - 2.1 6.9 7.2 2.3 6.8 5.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF935) Sugar_tr PF00083.19 CCF33731.1 - 1.4e-71 241.4 25.4 1.6e-71 241.2 17.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF33731.1 - 1.3e-19 70.1 29.4 1.3e-19 70.1 20.4 2.1 1 1 0 2 2 2 1 Major Facilitator Superfamily Fungal_trans PF04082.13 CCF33732.1 - 1.3e-13 50.4 0.3 3e-13 49.2 0.2 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF33732.1 - 0.00036 20.3 8.2 0.00068 19.5 5.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UPF0146 PF03686.8 CCF33732.1 - 0.2 11.4 0.0 0.39 10.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) ANTH PF07651.11 CCF33733.1 - 2.4e-81 272.5 0.0 2.4e-81 272.5 0.0 2.5 2 0 0 2 2 2 1 ANTH domain I_LWEQ PF01608.12 CCF33733.1 - 7e-64 214.3 8.8 7e-64 214.3 6.1 5.8 5 1 1 6 6 6 1 I/LWEQ domain ENTH PF01417.15 CCF33733.1 - 0.00056 19.7 0.0 0.0032 17.3 0.0 2.5 1 0 0 1 1 1 1 ENTH domain Med15 PF09606.5 CCF33733.1 - 1.6 6.8 34.3 3.5 5.6 23.8 1.5 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Ribosomal_L21e PF01157.13 CCF33734.1 - 5.2e-41 138.4 3.1 7.1e-41 138.0 2.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L21e Ribosomal_S4 PF00163.14 CCF33735.1 - 2.3e-29 101.6 0.9 4.7e-29 100.6 0.6 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 CCF33735.1 - 4.3e-13 48.4 1.2 4.3e-13 48.4 0.8 2.6 3 0 0 3 3 3 1 S4 domain tRNA-synt_2 PF00152.15 CCF33737.1 - 1.6e-70 237.5 0.0 2e-70 237.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 CCF33737.1 - 2.4e-08 33.6 0.0 4.4e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 CCF33737.1 - 1.5e-06 27.5 0.2 0.0046 16.1 0.0 2.8 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 CCF33737.1 - 0.041 13.4 0.0 4.2 6.9 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) HMG-CoA_red PF00368.13 CCF33738.1 - 7.2e-152 505.3 3.6 9.5e-152 504.9 2.5 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.1 CCF33738.1 - 2.6e-41 140.8 4.7 5e-41 139.9 3.3 1.5 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.3 CCF33738.1 - 2e-14 53.3 1.5 4.9e-14 52.0 1.0 1.7 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.13 CCF33738.1 - 5.5e-05 21.3 2.1 5.5e-05 21.3 1.5 1.6 2 0 0 2 2 2 1 Patched family KR PF08659.5 CCF33739.1 - 3.8e-65 218.9 1.1 3.8e-65 218.9 0.7 1.7 2 0 0 2 2 2 1 KR domain adh_short PF00106.20 CCF33739.1 - 3.9e-50 170.0 1.4 3.9e-50 170.0 1.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N PF00107.21 CCF33739.1 - 2.7e-20 72.2 0.1 1.1e-19 70.3 0.2 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF33739.1 - 2.1e-11 44.8 0.1 7.4e-11 43.0 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.20 CCF33739.1 - 4.8e-09 36.3 0.2 1.1e-08 35.1 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Saccharop_dh PF03435.13 CCF33739.1 - 0.00017 20.6 0.3 0.0003 19.8 0.0 1.5 2 0 0 2 2 2 1 Saccharopine dehydrogenase Epimerase PF01370.16 CCF33739.1 - 0.00071 19.0 0.0 0.0016 17.9 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.15 CCF33739.1 - 0.00072 19.6 0.0 0.024 14.7 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 3Beta_HSD PF01073.14 CCF33739.1 - 0.029 13.0 0.0 0.056 12.1 0.0 1.5 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 CCF33739.1 - 0.053 12.4 0.0 0.085 11.7 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ThiF PF00899.16 CCF33739.1 - 0.073 12.8 2.7 0.2 11.4 0.1 2.5 2 0 0 2 2 2 0 ThiF family NmrA PF05368.8 CCF33739.1 - 0.13 11.4 0.0 0.41 9.8 0.0 1.8 2 0 0 2 2 2 0 NmrA-like family PrpF PF04303.8 CCF33741.1 - 1.7e-89 300.2 0.0 2.1e-89 299.8 0.0 1.1 1 0 0 1 1 1 1 PrpF protein PBP PF01161.15 CCF33742.1 - 3.7e-19 69.0 0.0 4.9e-19 68.6 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Arginosuc_synth PF00764.14 CCF33744.1 - 1.6e-149 498.2 0.0 1.8e-149 498.0 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase Asn_synthase PF00733.16 CCF33744.1 - 0.011 15.2 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase QueC PF06508.8 CCF33744.1 - 0.056 12.7 0.0 0.085 12.1 0.0 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC Ribonuclease PF00545.15 CCF33745.1 - 8e-17 61.0 0.1 1.2e-16 60.4 0.1 1.2 1 0 0 1 1 1 1 ribonuclease DUF3632 PF12311.3 CCF33746.1 - 8e-40 136.6 4.4 1.1e-39 136.2 3.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) ABC_tran PF00005.22 CCF33747.1 - 1.1e-51 174.7 0.0 4e-30 104.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 CCF33747.1 - 5.5e-25 88.3 25.2 1.2e-14 54.3 8.5 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.14 CCF33747.1 - 2.5e-11 43.2 0.0 0.00011 21.5 0.0 4.2 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF33747.1 - 5.6e-10 39.6 0.0 0.018 15.0 0.0 3.3 2 1 1 3 3 3 3 AAA domain AAA_29 PF13555.1 CCF33747.1 - 3.1e-09 36.2 0.4 0.0032 16.9 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 CCF33747.1 - 4e-09 36.7 0.2 0.0037 17.3 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.1 CCF33747.1 - 4.2e-08 33.4 3.7 0.002 18.1 0.4 2.8 2 1 0 2 2 2 2 AAA ATPase domain AAA_17 PF13207.1 CCF33747.1 - 3.5e-07 31.0 0.1 0.011 16.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 CCF33747.1 - 5.3e-07 29.6 0.0 0.028 14.3 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase DUF258 PF03193.11 CCF33747.1 - 6e-07 28.7 0.1 0.013 14.7 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_10 PF12846.2 CCF33747.1 - 6.2e-07 29.1 0.0 0.027 13.8 0.0 2.5 2 0 0 2 2 2 2 AAA-like domain Miro PF08477.8 CCF33747.1 - 7.3e-07 29.7 0.0 0.016 15.6 0.0 2.6 2 0 0 2 2 2 2 Miro-like protein AAA_33 PF13671.1 CCF33747.1 - 1.2e-06 28.5 0.0 0.017 14.9 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_25 PF13481.1 CCF33747.1 - 2.6e-06 26.9 1.2 0.0046 16.3 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_23 PF13476.1 CCF33747.1 - 7.3e-06 26.4 0.1 0.13 12.5 0.1 2.3 2 0 0 2 2 2 2 AAA domain MobB PF03205.9 CCF33747.1 - 1.3e-05 24.9 0.1 0.19 11.4 0.0 2.5 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 CCF33747.1 - 2.2e-05 24.7 0.0 0.32 11.2 0.0 2.9 2 0 0 2 2 2 2 AAA domain FtsK_SpoIIIE PF01580.13 CCF33747.1 - 4.8e-05 22.9 0.1 0.051 13.0 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family Dynamin_N PF00350.18 CCF33747.1 - 0.0001 22.1 0.0 0.082 12.7 0.0 2.6 2 0 0 2 2 2 1 Dynamin family cobW PF02492.14 CCF33747.1 - 0.00015 21.2 1.2 0.028 13.8 0.3 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.12 CCF33747.1 - 0.00021 21.1 1.3 0.0037 17.1 0.0 2.5 3 0 0 3 3 2 1 Domain of unknown function DUF87 T2SE PF00437.15 CCF33747.1 - 0.00035 19.5 0.1 0.57 9.0 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein Zeta_toxin PF06414.7 CCF33747.1 - 0.00037 19.6 0.5 0.63 9.0 0.0 3.0 3 0 0 3 3 3 2 Zeta toxin AAA_30 PF13604.1 CCF33747.1 - 0.00053 19.6 0.2 1.5 8.3 0.0 3.3 3 1 0 3 3 2 1 AAA domain NACHT PF05729.7 CCF33747.1 - 0.00056 19.5 1.0 0.24 11.0 0.0 3.0 3 0 0 3 3 3 1 NACHT domain AAA_19 PF13245.1 CCF33747.1 - 0.00092 18.9 1.7 0.52 10.1 0.1 3.5 3 0 0 3 3 2 1 Part of AAA domain AAA_14 PF13173.1 CCF33747.1 - 0.0014 18.4 0.0 2.4 8.0 0.0 3.2 3 0 0 3 3 3 1 AAA domain GTP_EFTU PF00009.22 CCF33747.1 - 0.0018 17.7 0.1 0.21 11.0 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Arch_ATPase PF01637.13 CCF33747.1 - 0.0043 16.7 0.0 0.23 11.1 0.0 2.3 2 0 0 2 2 2 1 Archaeal ATPase AAA_5 PF07728.9 CCF33747.1 - 0.0061 16.2 0.2 0.65 9.7 0.0 2.7 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) DUF815 PF05673.8 CCF33747.1 - 0.0076 15.2 0.0 2.1 7.1 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) SbcCD_C PF13558.1 CCF33747.1 - 0.0078 16.1 0.2 1.1 9.2 0.0 3.1 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit IstB_IS21 PF01695.12 CCF33747.1 - 0.014 14.8 1.6 12 5.2 0.0 3.9 4 0 0 4 4 3 0 IstB-like ATP binding protein RNA_helicase PF00910.17 CCF33747.1 - 0.015 15.4 0.1 15 5.8 0.0 3.1 3 0 0 3 3 3 0 RNA helicase AAA PF00004.24 CCF33747.1 - 0.017 15.2 0.0 1.5 9.0 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATP_bind_1 PF03029.12 CCF33747.1 - 0.019 14.5 0.0 1.8 8.0 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.1 CCF33747.1 - 0.027 14.0 0.6 7.2 6.1 0.1 2.5 2 1 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 CCF33747.1 - 0.037 13.5 0.1 1.4 8.4 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NB-ARC PF00931.17 CCF33747.1 - 0.04 12.7 0.1 7.3 5.3 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain Adeno_IVa2 PF02456.10 CCF33747.1 - 0.053 12.1 0.0 5 5.6 0.0 2.6 3 0 0 3 3 3 0 Adenovirus IVa2 protein Septin PF00735.13 CCF33747.1 - 0.076 12.0 0.0 4.8 6.1 0.0 2.2 2 0 0 2 2 2 0 Septin NTPase_1 PF03266.10 CCF33747.1 - 0.097 12.3 1.1 8.6 6.0 0.0 2.5 2 0 0 2 2 2 0 NTPase DPBB_1 PF03330.13 CCF33747.1 - 0.12 12.4 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Rare lipoprotein A (RlpA)-like double-psi beta-barrel Viral_helicase1 PF01443.13 CCF33747.1 - 0.12 11.8 0.1 17 4.8 0.0 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.16 CCF33747.1 - 0.14 11.3 0.0 12 4.9 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DEAD PF00270.24 CCF33747.1 - 0.14 11.5 0.1 3.2 7.1 0.0 2.8 3 0 0 3 3 3 0 DEAD/DEAH box helicase AAA_28 PF13521.1 CCF33747.1 - 0.14 12.0 1.4 9.4 6.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain UPF0079 PF02367.12 CCF33747.1 - 0.18 11.4 0.1 2.4 7.8 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Guanylate_kin PF00625.16 CCF33747.1 - 0.22 10.9 0.1 1 8.7 0.0 2.0 2 0 0 2 2 2 0 Guanylate kinase G-alpha PF00503.15 CCF33747.1 - 0.39 9.3 0.2 11 4.5 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit Asn_synthase PF00733.16 CCF33748.1 - 6.7e-53 179.7 0.0 1.1e-52 179.1 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 CCF33748.1 - 5.4e-34 116.6 0.0 1.4e-33 115.3 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_6 PF13522.1 CCF33748.1 - 4.2e-29 101.1 0.1 2.4e-28 98.7 0.0 2.2 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.3 CCF33748.1 - 0.00033 19.9 0.0 0.0011 18.2 0.0 1.8 2 0 0 2 2 2 1 Aluminium induced protein tRNA_Me_trans PF03054.11 CCF33748.1 - 0.0064 15.1 0.0 0.0095 14.5 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase adh_short PF00106.20 CCF33749.1 - 1.4e-13 51.1 0.4 3.1e-13 49.9 0.1 1.7 2 0 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.1 CCF33749.1 - 3.9e-06 26.9 0.0 6.2e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding KR PF08659.5 CCF33749.1 - 4.1e-05 23.3 0.2 8e-05 22.3 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF33749.1 - 0.0033 16.8 0.1 0.0053 16.2 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 CCF33749.1 - 0.051 12.8 0.4 0.12 11.6 0.3 1.6 2 0 0 2 2 2 0 NmrA-like family BBE PF08031.7 CCF33750.1 - 7.1e-07 29.0 0.0 1.4e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like Cytokin-bind PF09265.5 CCF33750.1 - 0.044 12.9 0.0 0.053 12.6 0.0 1.1 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding p450 PF00067.17 CCF33751.1 - 5.9e-54 183.3 0.0 1.1e-53 182.4 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 CCF33752.1 - 6.9e-06 24.8 0.0 8.5e-06 24.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Zw10 PF06248.8 CCF33753.1 - 0.0011 17.2 0.1 0.47 8.5 0.0 2.2 2 0 0 2 2 2 2 Centromere/kinetochore Zw10 Dsl1_C PF11989.3 CCF33753.1 - 0.0037 16.4 0.0 0.018 14.2 0.0 2.0 2 1 0 2 2 2 1 Retrograde transport protein Dsl1 C terminal Nop14 PF04147.7 CCF33753.1 - 0.029 12.3 10.0 0.04 11.8 6.9 1.1 1 0 0 1 1 1 0 Nop14-like family p450 PF00067.17 CCF33754.1 - 0.0049 15.4 0.0 0.0053 15.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DSBA PF01323.15 CCF33755.1 - 1.8e-34 118.9 0.0 2.1e-34 118.7 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain DUF465 PF04325.8 CCF33755.1 - 0.026 14.2 1.1 0.042 13.5 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF465) Thioredoxin_5 PF13743.1 CCF33755.1 - 0.07 12.6 0.0 0.099 12.2 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin p450 PF00067.17 CCF33756.1 - 2.9e-49 167.8 0.0 6.6e-49 166.6 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 TFIIA PF03153.8 CCF33757.1 - 0.0018 18.2 4.3 0.0023 17.9 3.0 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF4551 PF15087.1 CCF33757.1 - 1.6 7.0 3.8 1.8 6.8 2.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF1676 PF07898.8 CCF33757.1 - 7.1 6.9 7.9 23 5.3 5.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1676) DUF1900 PF08954.6 CCF33758.1 - 1.5e-49 167.0 0.0 1.4e-48 163.8 0.0 2.3 2 1 1 3 3 3 1 Domain of unknown function (DUF1900) DUF1899 PF08953.6 CCF33758.1 - 3.3e-34 116.3 0.1 9.2e-34 114.9 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1899) WD40 PF00400.27 CCF33758.1 - 2.3e-27 93.8 2.7 1.6e-07 30.9 0.0 3.8 3 0 0 3 3 3 3 WD domain, G-beta repeat Phage_HK97_TLTM PF06120.6 CCF33758.1 - 0.031 13.5 1.5 0.051 12.9 1.0 1.2 1 0 0 1 1 1 0 Tail length tape measure protein Nucleoporin_N PF08801.6 CCF33758.1 - 0.061 12.0 0.2 1.5 7.5 0.2 2.3 1 1 1 2 2 2 0 Nup133 N terminal like Nup160 PF11715.3 CCF33758.1 - 0.073 11.1 0.6 1.1 7.3 0.0 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 TMPIT PF07851.8 CCF33758.1 - 0.1 11.6 1.9 0.16 10.9 1.3 1.2 1 0 0 1 1 1 0 TMPIT-like protein Gp58 PF07902.6 CCF33758.1 - 0.17 10.0 1.1 0.24 9.5 0.7 1.1 1 0 0 1 1 1 0 gp58-like protein Spc7 PF08317.6 CCF33758.1 - 0.27 9.8 3.7 0.39 9.3 2.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DivIC PF04977.10 CCF33758.1 - 0.87 9.1 4.9 1.2 8.7 2.7 1.7 1 1 0 1 1 1 0 Septum formation initiator Anillin PF08174.6 CCF33759.1 - 3.3e-37 127.6 0.2 8.2e-37 126.3 0.2 1.8 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.24 CCF33759.1 - 1.9e-09 37.6 0.0 6.3e-09 35.9 0.0 1.9 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 CCF33759.1 - 0.012 15.8 0.0 0.046 13.9 0.0 2.1 1 0 0 1 1 1 0 Pleckstrin homology domain HEAT PF02985.17 CCF33760.1 - 3.5e-23 79.5 17.8 0.0012 18.7 0.0 12.2 13 0 0 13 13 12 5 HEAT repeat HEAT_2 PF13646.1 CCF33760.1 - 2e-22 79.2 19.5 1.5e-08 34.8 0.2 9.1 4 3 4 8 8 8 7 HEAT repeats HEAT_EZ PF13513.1 CCF33760.1 - 8e-22 77.0 17.9 9.6e-09 35.4 0.1 10.3 8 1 2 10 10 9 5 HEAT-like repeat Vac14_Fab1_bd PF12755.2 CCF33760.1 - 2.2e-13 50.4 0.8 0.013 15.9 0.1 8.2 5 3 5 10 10 9 2 Vacuolar 14 Fab1-binding region MMS19_C PF12460.3 CCF33760.1 - 1.9e-08 33.4 0.1 2.9e-06 26.3 0.1 3.7 2 1 1 3 3 3 1 RNAPII transcription regulator C-terminal CLASP_N PF12348.3 CCF33760.1 - 6.6e-08 32.1 0.8 0.0011 18.4 0.1 5.5 4 1 1 6 6 6 1 CLASP N terminal RIX1 PF08167.7 CCF33760.1 - 1.1e-07 31.6 0.1 0.018 14.7 0.1 5.2 3 2 2 5 5 5 2 rRNA processing/ribosome biogenesis Cnd1 PF12717.2 CCF33760.1 - 1.8e-05 24.6 2.0 0.8 9.5 0.1 4.6 3 2 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Proteasom_PSMB PF10508.4 CCF33760.1 - 5.5e-05 21.6 0.0 0.00041 18.7 0.0 2.4 2 0 0 2 2 2 1 Proteasome non-ATPase 26S subunit DUF4042 PF13251.1 CCF33760.1 - 0.0001 21.8 0.2 8.2 5.8 0.0 5.4 5 0 0 5 5 5 0 Domain of unknown function (DUF4042) CAS_CSE1 PF03378.10 CCF33760.1 - 0.0011 17.3 0.2 2.3 6.4 0.0 3.6 3 0 0 3 3 3 2 CAS/CSE protein, C-terminus TAN PF11640.3 CCF33760.1 - 0.0057 16.4 2.9 0.051 13.3 0.1 3.2 2 1 1 3 3 3 1 Telomere-length maintenance and DNA damage repair Cohesin_HEAT PF12765.2 CCF33760.1 - 0.0091 15.9 0.7 1 9.4 0.0 3.8 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion DUF3554 PF12074.3 CCF33760.1 - 0.015 14.7 1.6 3.8 6.8 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF3554) DRIM PF07539.7 CCF33760.1 - 0.024 14.0 0.6 0.11 11.9 0.4 2.1 1 0 0 1 1 1 0 Down-regulated in metastasis Arm PF00514.18 CCF33760.1 - 0.037 13.8 13.5 12 5.8 0.1 6.4 7 0 0 7 7 6 0 Armadillo/beta-catenin-like repeat IBN_N PF03810.14 CCF33760.1 - 0.063 13.1 3.0 0.2 11.6 0.3 3.4 3 1 1 4 4 4 0 Importin-beta N-terminal domain V-ATPase_H_N PF03224.9 CCF33760.1 - 0.067 12.2 5.1 0.8 8.7 0.1 3.5 2 1 0 2 2 2 0 V-ATPase subunit H DUF445 PF04286.7 CCF33760.1 - 0.12 11.8 2.9 1.8 8.0 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF445) Imm47 PF15586.1 CCF33760.1 - 0.15 11.8 0.0 0.44 10.3 0.0 1.8 1 0 0 1 1 1 0 Immunity protein 47 F-box-like PF12937.2 CCF33761.1 - 0.003 17.2 0.0 0.0082 15.8 0.0 1.8 1 0 0 1 1 1 1 F-box-like CFEM PF05730.6 CCF33762.1 - 6.9e-10 38.6 8.0 1.6e-09 37.4 5.5 1.6 1 0 0 1 1 1 1 CFEM domain Adenylsucc_synt PF00709.16 CCF33763.1 - 6e-05 21.8 0.3 7e-05 21.6 0.2 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Adenylsucc_synt PF00709.16 CCF33764.1 - 3e-40 138.1 0.0 3.3e-40 138.0 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase zf-DNA_Pol PF08996.5 CCF33765.1 - 2.8e-30 105.0 0.1 3.1e-30 104.9 0.0 1.0 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger MIF4G PF02854.14 CCF33766.1 - 5.5e-51 172.9 0.0 1e-50 172.0 0.0 1.4 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.3 CCF33766.1 - 2.4e-22 78.5 0.9 8.5e-22 76.8 0.7 2.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 Methyltransf_2 PF00891.13 CCF33767.1 - 3.1e-30 105.1 0.0 4.1e-30 104.7 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Trp_DMAT PF11991.3 CCF33768.1 - 6e-46 157.3 0.0 6.8e-46 157.1 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Lactamase_B PF00753.22 CCF33769.1 - 5.8e-09 35.8 2.3 1.7e-08 34.3 1.6 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CCF33769.1 - 9.1e-05 22.0 0.3 0.00019 21.0 0.2 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 CCF33769.1 - 0.011 15.4 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Abhydrolase_3 PF07859.8 CCF33770.1 - 1.5e-18 67.1 0.2 2.1e-17 63.3 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF33770.1 - 4.6e-12 45.9 0.0 1.4e-11 44.3 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF33770.1 - 3.2e-09 36.3 0.0 9.5e-05 21.7 0.0 2.5 3 0 0 3 3 3 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 CCF33770.1 - 5.8e-08 32.9 6.1 5.8e-08 32.9 4.2 2.0 2 1 0 2 2 2 1 Alpha/beta hydrolase family Methyltransf_23 PF13489.1 CCF33770.1 - 4e-07 29.8 0.0 7.2e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF33770.1 - 2.8e-06 27.7 0.0 1e-05 25.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Peptidase_S15 PF02129.13 CCF33770.1 - 8.7e-06 25.3 0.0 4e-05 23.1 0.0 2.2 2 1 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.13 CCF33770.1 - 1.7e-05 24.2 0.0 0.013 14.8 0.0 2.3 2 0 0 2 2 2 2 Dienelactone hydrolase family COesterase PF00135.23 CCF33770.1 - 2.1e-05 23.4 0.0 3.1e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Methyltransf_11 PF08241.7 CCF33770.1 - 0.00021 21.7 0.0 0.0004 20.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Chlorophyllase2 PF12740.2 CCF33770.1 - 0.00049 19.0 0.0 0.00071 18.5 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_2 PF02230.11 CCF33770.1 - 0.0035 16.8 0.0 2.6 7.4 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Methyltransf_31 PF13847.1 CCF33770.1 - 0.0045 16.5 0.0 0.0069 15.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Esterase PF00756.15 CCF33770.1 - 0.0064 15.9 0.0 0.015 14.7 0.0 1.6 1 0 0 1 1 1 1 Putative esterase Chlorophyllase PF07224.6 CCF33770.1 - 0.069 11.9 0.0 0.12 11.1 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase AXE1 PF05448.7 CCF33770.1 - 0.098 11.1 0.0 0.22 10.0 0.0 1.5 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) LIP PF03583.9 CCF33770.1 - 0.11 11.7 0.0 1.2 8.2 0.0 2.0 2 0 0 2 2 2 0 Secretory lipase HET PF06985.6 CCF33771.1 - 3.3e-28 98.5 0.2 5e-28 97.9 0.1 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF605 PF04652.11 CCF33772.1 - 0.0031 16.9 15.2 0.0031 16.9 10.5 5.8 3 2 1 4 4 4 1 Vta1 like Mito_carr PF00153.22 CCF33773.1 - 1.1e-45 153.2 9.0 6.7e-17 60.9 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Fungal_trans PF04082.13 CCF33774.1 - 6.6e-29 100.5 0.0 2.1e-27 95.6 0.0 2.4 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF33774.1 - 2.5e-08 33.6 9.0 4.5e-08 32.8 6.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF33775.1 - 6.8e-38 130.2 0.0 7.5e-38 130.1 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain FMO-like PF00743.14 CCF33776.1 - 4.4e-44 150.5 0.0 4.8e-25 87.7 0.0 3.3 3 1 0 3 3 3 3 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.1 CCF33776.1 - 3.9e-15 55.9 0.6 5.4e-12 45.7 0.0 4.1 3 1 1 4 4 4 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 CCF33776.1 - 5e-15 56.1 0.0 4.7e-14 52.9 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF33776.1 - 8.8e-10 38.0 0.0 1.9e-07 30.3 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 CCF33776.1 - 4.3e-09 36.2 0.0 4.3e-08 33.0 0.0 2.6 3 0 0 3 3 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF33776.1 - 5.6e-09 36.1 0.0 1.2e-07 31.7 0.0 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF33776.1 - 1.2e-07 31.0 0.1 0.00014 20.9 0.0 3.5 2 1 1 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.12 CCF33776.1 - 1.1e-06 27.9 0.0 0.00083 18.5 0.0 2.2 2 0 0 2 2 2 2 Thi4 family HI0933_like PF03486.9 CCF33776.1 - 5.9e-06 24.9 0.0 0.0071 14.8 0.2 2.6 3 0 0 3 3 3 2 HI0933-like protein Pyr_redox PF00070.22 CCF33776.1 - 3.3e-05 24.2 0.0 0.017 15.5 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF33776.1 - 0.00071 18.5 0.1 0.18 10.6 0.0 2.6 3 0 0 3 3 3 1 FAD binding domain Amino_oxidase PF01593.19 CCF33776.1 - 0.0013 17.9 0.2 0.0038 16.3 0.1 1.7 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.14 CCF33776.1 - 0.0066 15.5 0.1 0.13 11.2 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain Shikimate_DH PF01488.15 CCF33776.1 - 0.0098 15.9 0.0 0.46 10.5 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 CCF33776.1 - 0.014 14.5 0.0 0.69 9.0 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Lycopene_cycl PF05834.7 CCF33776.1 - 0.015 14.2 0.0 1.1 8.1 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_Gly3P_dh_N PF01210.18 CCF33776.1 - 0.022 14.4 0.0 0.2 11.3 0.0 2.1 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus CPSase_L_chain PF00289.17 CCF33776.1 - 0.028 14.4 0.0 1.7 8.7 0.0 2.4 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, N-terminal domain TrkA_N PF02254.13 CCF33776.1 - 0.036 14.0 0.0 0.19 11.7 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain DJ-1_PfpI PF01965.19 CCF33776.1 - 0.066 12.6 0.0 4.5 6.7 0.0 2.3 2 0 0 2 2 2 0 DJ-1/PfpI family NAD_binding_7 PF13241.1 CCF33776.1 - 0.08 13.1 0.1 12 6.1 0.0 2.5 2 1 0 2 2 2 0 Putative NAD(P)-binding Strep_67kDa_ant PF06100.6 CCF33776.1 - 0.15 10.3 0.0 1.2 7.4 0.0 2.1 2 0 0 2 2 2 0 Streptococcal 67 kDa myosin-cross-reactive antigen like family Semialdhyde_dh PF01118.19 CCF33776.1 - 0.16 12.2 0.0 0.65 10.3 0.0 2.0 2 0 0 2 2 1 0 Semialdehyde dehydrogenase, NAD binding domain FAD_oxidored PF12831.2 CCF33776.1 - 0.17 10.9 0.0 0.37 9.8 0.0 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase MAF_flag10 PF01973.13 CCF33776.1 - 0.18 11.2 0.5 0.71 9.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function DUF115 Peptidase_M41 PF01434.13 CCF33778.1 - 2e-76 256.2 0.1 3.1e-76 255.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 CCF33778.1 - 8.7e-43 145.6 0.0 2.5e-42 144.1 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.10 CCF33778.1 - 4.1e-09 36.5 0.0 9.1e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.9 CCF33778.1 - 0.00022 20.9 0.0 0.0011 18.7 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 CCF33778.1 - 0.0025 17.2 1.1 0.023 14.1 0.2 2.6 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.1 CCF33778.1 - 0.0031 17.6 0.2 0.7 10.0 0.0 2.8 3 0 0 3 3 2 1 AAA domain TIP49 PF06068.8 CCF33778.1 - 0.0033 16.2 0.1 0.0065 15.2 0.1 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_19 PF13245.1 CCF33778.1 - 0.0051 16.5 1.0 0.034 13.8 0.4 2.3 2 0 0 2 2 2 1 Part of AAA domain AAA_17 PF13207.1 CCF33778.1 - 0.006 17.3 0.0 0.028 15.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 CCF33778.1 - 0.0071 15.4 0.0 0.019 14.0 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 CCF33778.1 - 0.013 15.3 0.1 0.075 12.9 0.0 2.3 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 CCF33778.1 - 0.018 15.0 0.2 0.4 10.6 0.1 2.6 1 1 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.7 CCF33778.1 - 0.026 13.6 0.0 0.06 12.4 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.1 CCF33778.1 - 0.033 14.0 0.0 0.17 11.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.12 CCF33778.1 - 0.034 13.5 0.0 0.08 12.3 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Thiolase_N PF00108.18 CCF33778.1 - 0.058 12.3 0.0 0.12 11.3 0.0 1.5 1 0 0 1 1 1 0 Thiolase, N-terminal domain Fungal_trans PF04082.13 CCF33779.1 - 2.7e-31 108.4 0.0 2.2e-30 105.3 0.0 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF33779.1 - 9.3e-11 41.4 12.0 1.7e-10 40.6 8.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TRI12 PF06609.8 CCF33780.1 - 9.4e-33 113.2 23.1 1.1e-32 112.9 16.0 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.11 CCF33780.1 - 2.5e-05 23.1 50.3 0.00014 20.7 34.9 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily RRM_1 PF00076.17 CCF33781.1 - 3.9e-14 52.0 0.1 8e-07 28.6 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF33781.1 - 7.6e-10 38.6 0.1 4.6e-05 23.3 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF33781.1 - 0.0049 16.6 0.0 0.97 9.3 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_M14 PF00246.19 CCF33782.1 - 5.6e-70 236.1 0.0 6.7e-70 235.8 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Dynamin_N PF00350.18 CCF33783.1 - 8.2e-16 58.2 0.0 1.2e-14 54.5 0.0 2.9 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.18 CCF33783.1 - 0.00042 20.2 0.1 0.0061 16.5 0.0 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CCF33783.1 - 0.0021 17.4 0.0 0.51 9.7 0.0 3.1 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain Miro PF08477.8 CCF33783.1 - 0.0083 16.6 0.0 0.1 13.0 0.0 2.7 2 0 0 2 2 2 1 Miro-like protein ABC_tran PF00005.22 CCF33783.1 - 0.009 16.3 0.6 0.062 13.6 0.0 2.7 3 0 0 3 3 3 1 ABC transporter AIG1 PF04548.11 CCF33783.1 - 0.01 14.9 0.0 0.034 13.2 0.0 1.9 1 0 0 1 1 1 0 AIG1 family DUF258 PF03193.11 CCF33783.1 - 0.025 13.7 0.0 0.1 11.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DUF87 PF01935.12 CCF33783.1 - 0.38 10.5 0.0 0.38 10.5 0.0 3.3 3 1 0 3 3 3 0 Domain of unknown function DUF87 Ammonium_transp PF00909.16 CCF33784.1 - 6.4e-96 321.2 22.1 7.8e-96 320.9 15.3 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF3445 PF11927.3 CCF33785.1 - 5.8e-71 238.7 0.0 7.7e-71 238.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Saf-Nte_pilin PF09460.5 CCF33786.1 - 0.12 12.1 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Saf-pilin pilus formation protein ketoacyl-synt PF00109.21 CCF33789.1 - 5.8e-22 78.4 0.0 2.3e-21 76.4 0.0 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain adh_short_C2 PF13561.1 CCF33789.1 - 1.9e-13 50.7 0.0 3.5e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase p450 PF00067.17 CCF33790.1 - 1.7e-63 214.7 0.0 2.3e-63 214.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PagL PF09411.5 CCF33791.1 - 0.028 14.5 0.0 0.036 14.1 0.0 1.1 1 0 0 1 1 1 0 Lipid A 3-O-deacylase (PagL) Abhydrolase_6 PF12697.2 CCF33792.1 - 2.3e-07 30.9 0.5 2.3e-07 30.9 0.3 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF33792.1 - 0.00038 20.2 0.0 0.00095 18.9 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF33792.1 - 0.082 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Methyltransf_2 PF00891.13 CCF33793.1 - 1.2e-22 80.3 0.0 7.3e-15 54.8 0.0 2.3 2 0 0 2 2 2 2 O-methyltransferase DUF3662 PF12401.3 CCF33793.1 - 0.068 13.3 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2662) Med4 PF10018.4 CCF33794.1 - 2.8e-12 46.4 4.3 4.5e-12 45.7 3.0 1.4 1 1 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 ARGLU PF15346.1 CCF33794.1 - 0.055 13.2 16.1 0.069 12.9 11.2 1.1 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 UDPG_MGDP_dh_C PF03720.10 CCF33794.1 - 0.055 13.6 0.2 0.084 13.0 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Methyltransf_14 PF08484.6 CCF33794.1 - 0.86 9.1 3.0 1.2 8.6 2.1 1.2 1 0 0 1 1 1 0 C-methyltransferase C-terminal domain Tom37_C PF11801.3 CCF33794.1 - 2 8.2 6.8 3.7 7.3 4.7 1.6 1 1 0 1 1 1 0 Tom37 C-terminal domain EMP70 PF02990.11 CCF33795.1 - 8.3e-191 634.9 6.1 1.1e-190 634.5 4.2 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 NfeD PF01957.13 CCF33795.1 - 0.055 13.6 0.0 0.055 13.6 0.0 4.5 2 2 3 5 5 5 0 NfeD-like C-terminal, partner-binding PIRT PF15099.1 CCF33795.1 - 0.25 10.5 0.9 0.55 9.4 0.6 1.5 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family Sas10_Utp3 PF04000.10 CCF33796.1 - 7.4e-16 58.1 2.1 1.6e-15 57.0 1.4 1.6 1 0 0 1 1 1 1 Sas10/Utp3/C1D family TRAP_alpha PF03896.11 CCF33796.1 - 0.72 8.8 7.0 1.9 7.4 4.9 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Myc_N PF01056.13 CCF33796.1 - 4.6 6.2 12.1 0.5 9.4 3.8 2.0 1 1 0 2 2 2 0 Myc amino-terminal region Pyr_redox_3 PF13738.1 CCF33797.1 - 4.5e-22 79.1 0.1 7.8e-21 75.0 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 CCF33797.1 - 5.5e-18 64.4 0.0 3e-17 62.0 0.0 2.0 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.9 CCF33797.1 - 8.1e-13 48.7 0.0 1.1e-09 38.5 0.0 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF33797.1 - 2.7e-11 42.9 0.1 1.6e-08 33.8 0.0 2.9 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 CCF33797.1 - 1.3e-06 28.3 0.5 5.5e-06 26.3 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF33797.1 - 1.5e-06 27.3 1.0 4.1e-06 25.9 0.0 2.1 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 CCF33797.1 - 0.00011 22.5 5.8 0.045 14.1 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 CCF33797.1 - 0.00038 20.5 0.1 0.29 11.2 0.0 2.6 3 0 0 3 3 3 2 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 CCF33797.1 - 0.002 17.8 0.1 0.0032 17.1 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.1 CCF33797.1 - 0.003 17.3 3.8 0.19 11.5 0.7 3.7 3 1 0 3 3 3 1 FAD-NAD(P)-binding HI0933_like PF03486.9 CCF33797.1 - 0.016 13.6 1.9 0.37 9.2 0.4 2.8 3 0 0 3 3 3 0 HI0933-like protein NAD_binding_7 PF13241.1 CCF33797.1 - 0.026 14.7 0.1 0.63 10.3 0.0 2.4 2 1 0 2 2 2 0 Putative NAD(P)-binding FAD_binding_2 PF00890.19 CCF33797.1 - 0.17 10.7 4.6 0.033 13.0 0.7 1.6 2 0 0 2 2 2 0 FAD binding domain AlaDh_PNT_C PF01262.16 CCF33797.1 - 0.24 10.9 2.9 6.5 6.2 0.0 2.5 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain AAA_11 PF13086.1 CCF33798.1 - 1.5e-17 63.9 0.0 2.6e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.1 CCF33798.1 - 1.4e-13 50.6 0.0 2.5e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 CCF33798.1 - 0.0091 15.5 0.0 2 7.8 0.0 3.0 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.1 CCF33798.1 - 0.01 15.5 0.1 0.071 12.8 0.0 2.4 3 0 0 3 3 3 0 Part of AAA domain AAA_25 PF13481.1 CCF33798.1 - 0.012 15.0 0.1 0.031 13.6 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 CCF33798.1 - 0.035 14.2 0.1 0.26 11.4 0.0 2.5 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.1 CCF33798.1 - 0.05 13.1 0.1 11 5.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 CCF33798.1 - 0.08 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family TPR_MLP1_2 PF07926.7 CCF33798.1 - 0.14 11.9 0.2 0.28 10.9 0.2 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Syndecan PF01034.15 CCF33799.1 - 0.13 11.9 0.5 0.25 10.9 0.4 1.4 1 0 0 1 1 1 0 Syndecan domain Adeno_E3_CR2 PF02439.10 CCF33799.1 - 0.23 11.0 3.6 0.39 10.3 2.5 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 HSP70 PF00012.15 CCF33801.1 - 8.8e-80 268.3 4.1 1.3e-79 267.7 2.8 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 CCF33801.1 - 2.5e-09 36.2 0.5 4e-09 35.5 0.3 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Hydantoinase_A PF01968.13 CCF33801.1 - 5.2e-05 22.4 0.8 0.018 14.1 0.1 2.7 2 1 1 3 3 3 2 Hydantoinase/oxoprolinase PilM_2 PF11104.3 CCF33801.1 - 0.0089 14.9 0.2 0.6 8.9 0.0 2.5 2 1 0 2 2 2 1 Type IV pilus assembly protein PilM; FtsA PF14450.1 CCF33801.1 - 0.015 15.1 3.7 1 9.2 0.1 2.9 2 1 0 2 2 2 0 Cell division protein FtsA NT-C2 PF10358.4 CCF33802.1 - 5.4e-26 90.7 0.1 9.4e-26 90.0 0.1 1.4 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Protamine_P2 PF00841.14 CCF33802.1 - 0.23 12.0 10.8 0.14 12.7 5.6 2.1 2 0 0 2 2 2 0 Sperm histone P2 DUF1275 PF06912.6 CCF33803.1 - 2.5e-42 144.4 5.9 3.1e-42 144.1 4.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) MFS_1 PF07690.11 CCF33803.1 - 0.00082 18.1 9.1 0.0079 14.9 1.4 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF4131 PF13567.1 CCF33803.1 - 0.15 11.4 8.5 0.88 8.9 1.4 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) Glyco_hydro_16 PF00722.16 CCF33804.1 - 8.7e-36 122.9 2.7 1.6e-35 122.0 1.9 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 DUF1049 PF06305.6 CCF33804.1 - 1.3 8.5 3.3 0.5 9.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) Fungal_trans_2 PF11951.3 CCF33806.1 - 5.7e-47 160.1 0.0 7.1e-47 159.8 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF33806.1 - 5.2e-07 29.4 6.0 1e-06 28.5 4.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ADH_N PF08240.7 CCF33807.1 - 7.4e-25 86.8 3.1 2.1e-24 85.3 2.2 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF33807.1 - 3.9e-14 52.3 0.1 6.5e-14 51.5 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TrkA_N PF02254.13 CCF33807.1 - 0.059 13.3 0.1 0.12 12.3 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox_3 PF13738.1 CCF33807.1 - 0.063 13.3 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.9 CCF33807.1 - 0.063 12.6 0.1 0.18 11.1 0.0 1.6 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_2 PF07992.9 CCF33807.1 - 0.12 12.2 0.9 0.29 10.9 0.2 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase adh_short_C2 PF13561.1 CCF33808.1 - 9.8e-38 130.2 0.1 1.2e-37 130.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF33808.1 - 2.8e-34 118.4 1.9 3.8e-34 118.0 1.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF33808.1 - 2.5e-16 59.8 0.3 3.5e-16 59.3 0.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF33808.1 - 1.8e-05 24.3 0.7 9e-05 22.0 0.5 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family FMN_dh PF01070.13 CCF33808.1 - 0.033 13.0 0.0 0.048 12.5 0.0 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase PK PF00224.16 CCF33808.1 - 0.044 12.4 0.0 3.5 6.1 0.0 2.1 1 1 1 2 2 2 0 Pyruvate kinase, barrel domain E1-N PF14463.1 CCF33808.1 - 0.064 12.8 0.9 5.4 6.5 0.2 2.3 2 0 0 2 2 2 0 E1 N-terminal domain Ssu72 PF04722.8 CCF33808.1 - 0.1 11.8 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Ssu72-like protein p450 PF00067.17 CCF33809.1 - 3.2e-38 131.4 0.0 3.9e-38 131.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Sugar_tr PF00083.19 CCF33810.1 - 1.6e-88 297.2 17.8 1.9e-88 297.0 12.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF33810.1 - 5.5e-20 71.3 52.6 1.4e-12 47.0 19.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Aminotran_1_2 PF00155.16 CCF33811.1 - 1.5e-38 132.6 0.0 1.8e-38 132.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 CCF33811.1 - 1.4e-06 27.3 0.0 2.7e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 CCF33811.1 - 1.7e-06 27.4 0.0 2.5e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 CCF33811.1 - 1.9e-05 23.1 0.0 2.6e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_MocR PF12897.2 CCF33811.1 - 5.9e-05 21.8 0.0 7.8e-05 21.4 0.0 1.1 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase DegT_DnrJ_EryC1 PF01041.12 CCF33811.1 - 0.012 14.6 0.0 0.019 14.0 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Alliinase_C PF04864.8 CCF33811.1 - 0.046 12.3 0.1 0.1 11.2 0.1 1.6 1 1 0 1 1 1 0 Allinase CPSase_L_D2 PF02786.12 CCF33812.1 - 7.5e-73 244.2 0.0 1.3e-72 243.5 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.14 CCF33812.1 - 8.6e-37 125.4 0.0 5.9e-36 122.7 0.0 2.2 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain CPSase_L_chain PF00289.17 CCF33812.1 - 9.4e-35 119.0 0.0 1.9e-34 118.0 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain ATP-grasp_4 PF13535.1 CCF33812.1 - 6.2e-17 61.9 0.0 1.4e-16 60.7 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl PF00364.17 CCF33812.1 - 1.7e-16 59.5 0.8 8e-16 57.4 0.5 2.3 2 0 0 2 2 2 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 CCF33812.1 - 2.1e-15 56.2 0.0 3.4e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl_2 PF13533.1 CCF33812.1 - 2.1e-08 33.7 0.1 0.0043 16.6 0.0 3.0 2 1 1 3 3 3 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.8 CCF33812.1 - 5.4e-08 32.4 0.0 1.4e-07 31.1 0.0 1.7 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 CCF33812.1 - 1.1e-05 24.8 0.0 2.7e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain HlyD PF00529.15 CCF33812.1 - 8.4e-05 22.0 0.0 0.13 11.4 0.0 2.4 1 1 1 2 2 2 2 HlyD family secretion protein HlyD_3 PF13437.1 CCF33812.1 - 0.0001 22.6 0.1 0.82 10.0 0.0 3.1 3 0 0 3 3 2 2 HlyD family secretion protein ATP-grasp_3 PF02655.9 CCF33812.1 - 0.0011 18.8 0.0 0.0032 17.3 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.6 CCF33812.1 - 0.0016 17.9 0.0 0.025 14.0 0.0 2.5 2 1 0 2 2 2 1 RimK-like ATP-grasp domain HlyD_2 PF12700.2 CCF33812.1 - 0.068 12.3 0.6 5.9 5.9 0.0 2.5 2 1 1 3 3 3 0 HlyD family secretion protein Pyridox_oxidase PF01243.15 CCF33813.1 - 4e-13 49.1 0.0 5.1e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Gpi16 PF04113.9 CCF33813.1 - 0.00088 17.4 0.1 0.00097 17.2 0.1 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Pyrid_oxidase_2 PF13883.1 CCF33813.1 - 0.06 13.1 0.2 0.064 13.0 0.1 1.1 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.2 CCF33813.1 - 0.12 12.1 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Epimerase PF01370.16 CCF33814.1 - 6.4e-12 45.4 0.4 7.7e-11 41.8 0.3 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 CCF33814.1 - 5.6e-07 28.7 0.0 7.7e-07 28.2 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 CCF33814.1 - 0.00019 20.2 0.0 0.00064 18.5 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 CCF33814.1 - 0.072 13.0 0.5 0.47 10.3 0.2 2.1 2 0 0 2 2 2 0 short chain dehydrogenase Aldedh PF00171.17 CCF33815.1 - 3.7e-117 391.4 0.2 1.1e-115 386.6 0.1 2.0 1 1 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 CCF33815.1 - 4e-07 29.1 0.0 1.3e-06 27.3 0.0 1.7 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) L1R_F9L PF02442.12 CCF33815.1 - 0.03 13.7 0.0 0.077 12.4 0.0 1.6 1 1 0 1 1 1 0 Lipid membrane protein of large eukaryotic DNA viruses Flavi_propep PF01570.12 CCF33815.1 - 0.1 12.3 0.3 0.23 11.1 0.2 1.6 1 0 0 1 1 1 0 Flavivirus polyprotein propeptide Ald_Xan_dh_C2 PF02738.13 CCF33816.1 - 1.3e-147 492.4 0.1 1.7e-147 492.0 0.1 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.16 CCF33816.1 - 6.5e-49 165.6 0.0 1.7e-48 164.3 0.0 1.7 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.17 CCF33816.1 - 1.4e-33 115.3 0.0 2.7e-33 114.3 0.0 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.12 CCF33816.1 - 4.9e-31 106.7 0.9 1.7e-30 104.9 0.1 2.4 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.15 CCF33816.1 - 3.6e-29 100.4 0.1 7.3e-29 99.4 0.1 1.6 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.22 CCF33816.1 - 2.4e-08 33.5 1.6 5.1e-08 32.5 0.1 2.4 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DUF218 PF02698.12 CCF33816.1 - 0.016 14.6 0.0 0.033 13.6 0.0 1.4 1 0 0 1 1 1 0 DUF218 domain DUF330 PF03886.8 CCF33816.1 - 0.15 11.4 0.0 0.55 9.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF330) Iso_dh PF00180.15 CCF33817.1 - 5.4e-82 275.5 0.0 6.4e-82 275.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase adh_short PF00106.20 CCF33820.1 - 2.7e-17 63.2 0.1 3.9e-17 62.6 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF33820.1 - 2.6e-07 30.5 0.1 4.4e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 CCF33820.1 - 0.057 12.3 0.0 0.092 11.6 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.16 CCF33820.1 - 0.058 12.8 0.3 0.17 11.3 0.0 1.9 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family HET PF06985.6 CCF33822.1 - 1.1e-21 77.4 0.0 2.1e-21 76.5 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Abhydrolase_6 PF12697.2 CCF33823.1 - 2.7e-19 69.9 0.5 5e-19 69.0 0.4 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF33823.1 - 3.6e-08 33.2 0.4 4.1e-07 29.7 0.0 2.7 2 1 0 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF33823.1 - 1.2e-07 31.6 0.1 4.6e-07 29.6 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CCF33823.1 - 0.0083 15.9 0.0 0.077 12.8 0.0 2.2 2 0 0 2 2 2 1 Putative lysophospholipase DUF1057 PF06342.7 CCF33823.1 - 0.022 13.5 0.0 0.034 12.9 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) ARD PF03079.9 CCF33824.1 - 5.5e-46 156.3 0.8 6.8e-46 156.0 0.6 1.1 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.6 CCF33824.1 - 6.1e-09 35.2 0.2 1e-08 34.5 0.1 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.14 CCF33824.1 - 0.00067 19.3 0.1 0.00092 18.9 0.1 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.17 CCF33824.1 - 0.017 14.5 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 Cupin DER1 PF04511.10 CCF33825.1 - 2.6e-51 173.9 4.4 3e-51 173.7 3.1 1.0 1 0 0 1 1 1 1 Der1-like family Histone PF00125.19 CCF33826.1 - 6.4e-30 103.0 0.6 8.9e-30 102.6 0.4 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 CCF33826.1 - 7e-05 22.9 0.1 0.0001 22.4 0.1 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CENP-T PF15511.1 CCF33826.1 - 0.0044 16.3 1.4 0.0075 15.5 1.0 1.5 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T CBFD_NFYB_HMF PF00808.18 CCF33826.1 - 0.0059 16.6 0.1 0.009 16.0 0.1 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Peptidase_M24 PF00557.19 CCF33827.1 - 5.9e-42 143.5 0.1 8.2e-42 143.1 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.13 CCF33827.1 - 1.1e-11 45.3 0.0 1.6e-06 28.6 0.0 2.4 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain p450 PF00067.17 CCF33828.1 - 1.1e-68 231.9 0.0 1.3e-68 231.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HMG_CoA_synt_C PF08540.5 CCF33829.1 - 2.1e-94 316.1 0.1 2.7e-94 315.8 0.1 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.12 CCF33829.1 - 2.1e-62 209.7 0.1 3.2e-62 209.1 0.1 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal ACP_syn_III PF08545.5 CCF33829.1 - 0.01 15.4 0.1 0.018 14.6 0.1 1.4 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ArfGap PF01412.13 CCF33832.1 - 8.1e-37 125.5 0.1 9.7e-37 125.3 0.1 1.0 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf TIM21 PF08294.6 CCF33833.1 - 5.3e-46 155.8 0.0 6.5e-46 155.6 0.0 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.5 CCF33833.1 - 2.9e-07 29.9 0.0 4.1e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 RNA_pol_Rpb2_6 PF00562.23 CCF33834.1 - 2e-116 388.9 0.0 3.2e-116 388.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 CCF33834.1 - 2.3e-51 173.6 0.6 3.8e-51 172.8 0.2 1.6 2 0 0 2 2 2 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 CCF33834.1 - 1.4e-30 106.1 0.1 2.9e-30 105.0 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.15 CCF33834.1 - 4.1e-30 103.8 0.3 1.1e-29 102.4 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.8 CCF33834.1 - 8.8e-21 73.4 0.1 2.4e-20 72.0 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.11 CCF33834.1 - 3.2e-20 71.6 0.0 6.3e-20 70.6 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.12 CCF33834.1 - 2.1e-11 43.6 0.7 8.7e-11 41.6 0.7 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 DNA_mis_repair PF01119.14 CCF33836.1 - 2.8e-20 71.9 0.0 6.1e-20 70.8 0.0 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.6 CCF33836.1 - 8.4e-19 67.6 0.0 2e-18 66.3 0.0 1.6 1 0 0 1 1 1 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.1 CCF33836.1 - 6.3e-14 51.8 0.1 1.5e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 CCF33836.1 - 2.2e-12 46.6 0.0 5e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase V-SNARE PF05008.10 CCF33837.1 - 1.6e-06 28.1 6.2 0.00024 21.1 0.0 3.5 3 0 0 3 3 3 1 Vesicle transport v-SNARE protein N-terminus BLOC1_2 PF10046.4 CCF33837.1 - 0.013 15.6 2.9 4.2 7.5 0.3 3.7 4 1 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PilJ PF13675.1 CCF33837.1 - 0.032 14.5 1.9 3.7 7.8 0.0 3.3 2 1 1 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term PTPA PF03095.10 CCF33837.1 - 0.037 13.1 1.1 4.8 6.2 0.3 2.5 2 0 0 2 2 2 0 Phosphotyrosyl phosphate activator (PTPA) protein Baculo_PEP_C PF04513.7 CCF33837.1 - 0.08 12.7 3.4 1.2 8.9 0.6 2.9 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.7 CCF33837.1 - 0.62 10.3 4.6 9.2 6.5 0.5 3.6 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein MCPsignal PF00015.16 CCF33837.1 - 0.79 9.2 5.6 0.85 9.1 2.2 2.2 3 0 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Cast PF10174.4 CCF33837.1 - 1.1 7.1 7.4 0.041 11.9 0.2 2.0 3 0 0 3 3 3 0 RIM-binding protein of the cytomatrix active zone DUF1664 PF07889.7 CCF33837.1 - 1.7 8.4 6.4 0.36 10.6 0.3 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) Epimerase PF01370.16 CCF33839.1 - 1.6e-15 57.2 0.1 3.6e-15 56.0 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF33839.1 - 6e-13 48.1 0.0 1.6e-12 46.7 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 CCF33839.1 - 1.6e-08 34.8 0.0 3.7e-08 33.6 0.0 1.6 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 CCF33839.1 - 1.4e-07 30.7 0.1 0.0013 17.6 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.8 CCF33839.1 - 2.4e-05 23.6 0.0 3.6e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.10 CCF33839.1 - 0.00018 20.5 0.0 0.0003 19.8 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 CCF33839.1 - 0.00058 19.8 0.1 0.005 16.7 0.1 2.4 1 1 0 1 1 1 1 short chain dehydrogenase Gpi1 PF05024.10 CCF33841.1 - 3.2e-62 209.5 6.8 6e-62 208.6 4.7 1.5 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) ABC_membrane PF00664.18 CCF33842.1 - 4.1e-53 180.5 22.0 1.2e-38 133.1 5.0 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 CCF33842.1 - 7.9e-29 100.7 0.1 2.3e-28 99.2 0.0 1.9 2 0 0 2 2 1 1 ABC transporter SMC_N PF02463.14 CCF33842.1 - 5.9e-07 28.9 0.0 0.0002 20.6 0.0 2.4 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF33842.1 - 0.0047 16.9 0.0 0.96 9.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 CCF33842.1 - 0.01 15.3 0.3 0.024 14.1 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_17 PF13207.1 CCF33842.1 - 0.017 15.9 0.0 0.045 14.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CCF33842.1 - 0.018 15.0 0.1 0.043 13.8 0.1 1.6 1 0 0 1 1 1 0 AAA ATPase domain APS_kinase PF01583.15 CCF33842.1 - 0.034 13.8 0.1 0.067 12.8 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase DUF87 PF01935.12 CCF33842.1 - 0.094 12.5 1.9 0.089 12.5 0.3 1.6 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_22 PF13401.1 CCF33842.1 - 0.099 12.7 0.1 5.6 7.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 CCF33842.1 - 0.12 11.8 0.5 2.1 7.6 0.1 2.2 2 0 0 2 2 2 0 AAA-like domain AAA_33 PF13671.1 CCF33842.1 - 0.12 12.2 0.0 0.41 10.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain Pyr_redox PF00070.22 CCF33843.1 - 2.5e-13 50.2 0.4 2.5e-12 47.0 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF33843.1 - 1.9e-10 41.1 0.0 6.3e-05 23.1 0.0 3.1 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CCF33843.1 - 2.7e-10 40.4 0.0 6e-05 23.0 0.0 2.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF33843.1 - 1.3e-05 24.2 0.0 2.7e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.7 CCF33843.1 - 0.0012 17.8 0.0 0.002 17.1 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.9 CCF33843.1 - 0.0055 15.2 0.2 0.41 9.0 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein DAO PF01266.19 CCF33843.1 - 0.016 14.1 0.2 0.037 12.9 0.1 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase Trp_halogenase PF04820.9 CCF33843.1 - 0.018 13.7 0.0 3.5 6.1 0.1 2.1 2 0 0 2 2 2 0 Tryptophan halogenase HEAT PF02985.17 CCF33845.1 - 0.00033 20.4 0.6 8.4 6.7 0.0 5.1 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.1 CCF33845.1 - 0.0013 18.9 3.4 0.14 12.4 0.1 4.5 5 0 0 5 5 5 1 HEAT repeats HEAT_EZ PF13513.1 CCF33845.1 - 0.0025 18.2 3.9 0.84 10.2 0.0 5.1 5 0 0 5 5 5 1 HEAT-like repeat GFO_IDH_MocA_C PF02894.12 CCF33846.1 - 5.8e-18 64.7 0.4 5.7e-17 61.5 0.2 2.5 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain GFO_IDH_MocA PF01408.17 CCF33846.1 - 1.5e-15 57.7 0.0 2.6e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold MFS_1 PF07690.11 CCF33847.1 - 7.8e-32 110.3 31.9 7.8e-32 110.3 22.1 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Pox_A14 PF05767.7 CCF33847.1 - 0.052 13.5 1.6 6.1 6.8 0.0 3.1 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 IncA PF04156.9 CCF33847.1 - 1.2 8.6 0.0 1.2 8.6 0.0 3.0 4 0 0 4 4 4 0 IncA protein WSC PF01822.14 CCF33848.1 - 3.6e-22 78.0 6.1 3.6e-22 78.0 4.3 1.8 2 0 0 2 2 2 1 WSC domain Fungal_trans PF04082.13 CCF33850.1 - 7.1e-15 54.5 0.0 1.3e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF33850.1 - 1.5e-05 24.7 6.8 2.7e-05 23.9 4.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DDE_Tnp_1_6 PF13751.1 CCF33850.1 - 0.03 14.3 3.7 0.053 13.5 2.6 1.4 1 0 0 1 1 1 0 Transposase DDE domain DUF3027 PF11228.3 CCF33850.1 - 0.036 13.7 0.9 0.063 12.9 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3027) YqeY PF09424.5 CCF33851.1 - 1.5e-23 83.2 2.4 1.9e-23 82.9 1.6 1.1 1 0 0 1 1 1 1 Yqey-like protein Methyltransf_23 PF13489.1 CCF33853.1 - 1.2e-11 44.6 0.0 2.4e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF33853.1 - 1.6e-09 38.0 0.0 2.8e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF33853.1 - 3.3e-05 24.4 0.0 8.4e-05 23.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF33853.1 - 0.0001 21.4 0.0 0.00017 20.7 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.7 CCF33853.1 - 0.00064 20.1 0.0 0.0013 19.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF33853.1 - 0.00083 19.6 0.0 0.0028 18.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF33853.1 - 0.021 14.8 0.0 0.043 13.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.13 CCF33853.1 - 0.036 13.1 0.0 0.19 10.8 0.0 2.1 1 1 1 2 2 2 0 ubiE/COQ5 methyltransferase family DUF3328 PF11807.3 CCF33854.1 - 0.071 12.7 4.0 0.32 10.6 2.8 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3328) Acetyltransf_1 PF00583.19 CCF33855.1 - 1.7e-07 31.1 0.1 5.8e-07 29.4 0.1 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF33855.1 - 1.7e-06 28.1 0.0 5.3e-06 26.4 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CCF33855.1 - 0.00083 19.4 0.0 0.0024 17.9 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 CCF33855.1 - 0.026 14.3 0.0 0.055 13.3 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DUF3328 PF11807.3 CCF33856.1 - 0.00055 19.6 2.9 0.0019 17.9 2.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3357 PF11837.3 CCF33856.1 - 0.075 12.8 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) p450 PF00067.17 CCF33857.1 - 3.2e-41 141.3 0.0 6.4e-41 140.3 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Alpha-amylase PF00128.19 CCF33858.1 - 7.3e-57 193.1 0.0 1.1e-56 192.6 0.0 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.6 CCF33858.1 - 8.6e-14 51.3 0.0 2.4e-13 49.9 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1966) Glyco_hydro_31 PF01055.21 CCF33858.1 - 0.001 17.9 0.0 0.0012 17.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 PTR2 PF00854.16 CCF33859.1 - 3.2e-21 75.5 14.3 1.3e-16 60.3 1.2 2.3 3 0 0 3 3 3 2 POT family MFS_1 PF07690.11 CCF33859.1 - 9.8e-06 24.5 10.8 6.7e-05 21.7 6.6 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.11 CCF33860.1 - 3.1e-32 111.6 38.2 4.1e-32 111.2 24.6 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF33860.1 - 6.4e-10 38.1 8.0 6.4e-10 38.1 5.6 2.1 2 1 2 4 4 4 1 Sugar (and other) transporter TRI12 PF06609.8 CCF33860.1 - 0.0074 14.5 4.2 0.011 13.9 2.9 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Velvet PF11754.3 CCF33861.1 - 8.9e-35 120.1 0.0 1.5e-34 119.4 0.0 1.3 1 0 0 1 1 1 1 Velvet factor DUF605 PF04652.11 CCF33861.1 - 2.2 7.5 23.3 3 7.1 16.1 1.3 1 0 0 1 1 1 0 Vta1 like DUF4636 PF15468.1 CCF33862.1 - 0.041 13.3 0.0 0.053 12.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) Dynamin_M PF01031.15 CCF33863.1 - 3.7e-112 373.9 0.0 1.2e-111 372.2 0.0 1.8 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.18 CCF33863.1 - 4.2e-56 189.3 0.8 6.6e-56 188.7 0.0 1.8 2 0 0 2 2 2 1 Dynamin family GED PF02212.13 CCF33863.1 - 7.5e-31 105.8 1.7 7.5e-31 105.8 1.2 2.4 3 0 0 3 3 3 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 CCF33863.1 - 0.00073 19.4 0.0 0.003 17.5 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CCF33863.1 - 0.013 15.9 0.0 0.048 14.1 0.0 2.0 2 0 0 2 2 2 0 Miro-like protein CHCH PF06747.8 CCF33864.1 - 0.00063 19.5 0.4 0.0014 18.5 0.3 1.6 1 1 1 2 2 2 1 CHCH domain Pet191_N PF10203.4 CCF33864.1 - 0.0022 18.0 1.4 0.013 15.5 1.0 1.9 1 1 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 COX17 PF05051.8 CCF33864.1 - 0.02 14.9 2.8 0.21 11.6 0.3 2.0 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.5 CCF33864.1 - 0.025 14.3 1.8 0.075 12.8 1.3 1.7 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like Ferritin PF00210.19 CCF33864.1 - 0.098 12.4 0.0 0.11 12.2 0.0 1.0 1 0 0 1 1 1 0 Ferritin-like domain UPF0203 PF05254.7 CCF33864.1 - 0.11 12.4 2.1 4.6 7.1 0.1 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) LIM PF00412.17 CCF33866.1 - 1.3e-15 57.1 22.9 1.5e-08 34.5 4.2 2.9 4 0 0 4 4 4 2 LIM domain DUF2321 PF10083.4 CCF33866.1 - 0.29 10.6 6.0 0.083 12.3 0.4 2.6 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-dskA_traR PF01258.12 CCF33866.1 - 1.9 8.3 12.6 0.68 9.7 0.4 3.9 3 1 0 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger Rad60-SLD PF11976.3 CCF33867.1 - 4.7e-20 71.0 0.2 5.9e-20 70.7 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 CCF33867.1 - 6.8e-09 35.0 0.1 8.3e-09 34.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family HH_signal PF01085.13 CCF33867.1 - 0.015 14.9 0.0 0.015 14.8 0.0 1.0 1 0 0 1 1 1 0 Hedgehog amino-terminal signalling domain Lactamase_B PF00753.22 CCF33868.1 - 9.1e-08 31.9 0.9 1.3e-07 31.4 0.6 1.4 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CCF33868.1 - 0.042 13.3 0.0 0.066 12.7 0.0 1.3 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Mito_carr PF00153.22 CCF33869.1 - 1.5e-18 66.2 0.1 3.1e-11 42.8 0.0 3.8 4 1 0 4 4 4 2 Mitochondrial carrier protein GMC_oxred_N PF00732.14 CCF33870.1 - 3.5e-52 177.3 0.0 4.8e-52 176.9 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF33870.1 - 2.1e-28 99.4 0.0 3.6e-28 98.6 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 CCF33870.1 - 1.1e-05 24.5 5.5 0.00021 20.2 4.0 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CCF33870.1 - 2.3e-05 23.4 2.3 0.0016 17.3 0.1 2.4 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.9 CCF33870.1 - 0.00025 21.0 0.2 0.37 10.6 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF33870.1 - 0.00037 20.4 0.4 0.0019 18.1 0.2 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 CCF33870.1 - 0.0017 17.5 0.1 0.0029 16.7 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.1 CCF33870.1 - 0.0078 16.2 0.5 0.3 11.1 0.2 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.13 CCF33870.1 - 0.079 12.9 1.5 0.15 12.1 0.2 2.0 2 0 0 2 2 2 0 TrkA-N domain HI0933_like PF03486.9 CCF33870.1 - 0.1 11.0 0.3 0.42 9.0 0.0 1.9 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_9 PF13454.1 CCF33870.1 - 0.13 12.0 2.9 0.15 11.8 0.2 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding 2OG-FeII_Oxy_2 PF13532.1 CCF33871.1 - 3.4e-32 111.8 0.0 6.6e-32 110.9 0.0 1.4 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 CCF33871.1 - 0.0047 17.4 0.0 0.0096 16.4 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pkinase PF00069.20 CCF33872.1 - 2.8e-71 239.7 0.0 3.7e-71 239.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF33872.1 - 7.3e-31 107.1 0.0 9.5e-31 106.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF33872.1 - 0.0029 16.6 0.0 0.0046 15.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CCF33872.1 - 0.0067 16.1 0.1 0.012 15.3 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 CCF33872.1 - 0.027 13.3 0.0 0.04 12.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Methyltransf_2 PF00891.13 CCF33873.1 - 2.5e-25 89.0 0.0 3.4e-25 88.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase DUF1993 PF09351.5 CCF33874.1 - 8.5e-52 175.3 0.0 9.6e-52 175.1 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) Ribosomal_S16 PF00886.14 CCF33876.1 - 8.9e-24 82.9 0.1 1.3e-23 82.4 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S16 Aa_trans PF01490.13 CCF33877.1 - 2e-90 303.2 19.3 2e-90 303.2 13.4 1.3 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Pax2_C PF12403.3 CCF33880.1 - 0.29 10.8 1.9 1.1 8.9 0.9 1.9 1 1 1 2 2 2 0 Paired-box protein 2 C terminal Pyridox_ox_2 PF12900.2 CCF33881.1 - 7.5e-39 132.8 0.0 1.2e-38 132.1 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase p450 PF00067.17 CCF33883.1 - 4.3e-76 256.2 0.0 5.2e-76 256.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Tautomerase_3 PF14832.1 CCF33884.1 - 2.2e-51 173.4 0.1 2.4e-51 173.3 0.0 1.0 1 0 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme CVNH PF08881.5 CCF33885.1 - 3.5e-39 133.1 0.6 6.6e-39 132.3 0.4 1.5 1 0 0 1 1 1 1 CVNH domain LysM PF01476.15 CCF33885.1 - 1.6e-13 50.3 0.0 2.6e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 LysM domain Rick_17kDa_Anti PF05433.10 CCF33885.1 - 0.00036 20.1 5.9 0.00097 18.7 4.1 1.8 1 0 0 1 1 1 1 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.1 CCF33885.1 - 0.0078 15.8 3.5 0.017 14.7 2.4 1.6 1 0 0 1 1 1 1 Glycine zipper Gly-zipper_YMGG PF13441.1 CCF33885.1 - 0.038 13.5 3.1 0.078 12.5 2.1 1.5 1 0 0 1 1 1 0 YMGG-like Gly-zipper Zip PF02535.17 CCF33885.1 - 1 8.2 6.3 1.5 7.7 4.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Aldedh PF00171.17 CCF33886.1 - 3e-156 520.3 0.1 3.4e-156 520.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 CCF33886.1 - 0.018 14.2 0.0 0.22 10.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) 2OG-Fe_Oxy_2 PF10014.4 CCF33887.1 - 0.0034 16.7 0.0 0.0056 16.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe dioxygenase 2OG-FeII_Oxy_3 PF13640.1 CCF33887.1 - 0.022 15.2 0.0 0.042 14.3 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Zn_clus PF00172.13 CCF33889.1 - 4.7 7.2 14.8 0.54 10.2 6.6 2.0 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain dCMP_cyt_deam_1 PF00383.17 CCF33890.1 - 3.1e-21 74.9 0.0 1.2e-20 72.9 0.0 2.0 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.1 CCF33890.1 - 0.00097 19.0 4.3 0.0053 16.6 0.0 2.9 3 0 0 3 3 3 1 Bd3614-like deaminase Xan_ur_permease PF00860.15 CCF33891.1 - 8.7e-15 54.0 12.3 1.2e-14 53.6 8.5 1.1 1 0 0 1 1 1 1 Permease family Sulfate_transp PF00916.15 CCF33891.1 - 0.00026 20.1 4.9 0.0013 17.8 2.3 2.2 1 1 1 2 2 2 1 Sulfate transporter family p450 PF00067.17 CCF33894.1 - 8.1e-13 47.6 0.0 1.1e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 GCV_H PF01597.14 CCF33895.1 - 0.11 12.2 1.0 0.2 11.3 0.7 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein Glyco_hydro_61 PF03443.9 CCF33897.1 - 3.7e-64 216.5 0.1 4.2e-64 216.3 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Glyco_hydro_28 PF00295.12 CCF33898.1 - 5.7e-61 206.2 9.4 1.2e-50 172.4 2.9 2.0 2 0 0 2 2 2 2 Glycosyl hydrolases family 28 3-HAO PF06052.7 CCF33899.1 - 6.8e-64 213.8 0.0 7.7e-64 213.6 0.0 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.6 CCF33899.1 - 4.1e-06 26.2 0.0 6.2e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.17 CCF33899.1 - 0.0017 17.7 0.0 0.0027 17.1 0.0 1.3 1 0 0 1 1 1 1 Cupin DZR PF12773.2 CCF33899.1 - 0.0035 17.1 3.0 0.0077 16.0 2.1 1.6 1 0 0 1 1 1 1 Double zinc ribbon AraC_binding PF02311.14 CCF33899.1 - 0.0043 16.7 0.0 0.0072 16.0 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Nudix_N_2 PF14803.1 CCF33899.1 - 0.022 14.4 2.3 2.7 7.7 0.1 2.4 2 0 0 2 2 2 0 Nudix N-terminal Zn_Tnp_IS1595 PF12760.2 CCF33899.1 - 0.055 13.2 0.5 6.8 6.5 0.1 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Cupin_4 PF08007.7 CCF33899.1 - 0.13 11.4 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Cupin superfamily protein zf-DHHC PF01529.15 CCF33899.1 - 3.2 7.1 5.0 1.9 7.8 0.7 2.1 1 1 1 2 2 2 0 DHHC palmitoyltransferase C1_1 PF00130.17 CCF33899.1 - 4.4 7.1 6.1 2.6 7.8 0.8 2.3 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ADK_lid PF05191.9 CCF33899.1 - 6.1 6.5 6.2 34 4.1 2.6 2.8 2 1 0 2 2 2 0 Adenylate kinase, active site lid FAA_hydrolase PF01557.13 CCF33900.1 - 1.1e-49 168.8 0.0 1.3e-49 168.5 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family LcrG PF07216.7 CCF33901.1 - 0.23 11.5 2.4 5.1 7.1 0.9 2.3 2 0 0 2 2 2 0 LcrG protein Pkinase_Tyr PF07714.12 CCF33902.1 - 1.7e-05 23.9 0.0 0.0043 16.1 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 CCF33902.1 - 2.9e-05 23.3 0.0 0.00014 21.1 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Zn_clus PF00172.13 CCF33903.1 - 1.6e-07 31.1 7.0 3.3e-07 30.1 4.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2605 PF10792.4 CCF33904.1 - 0.03 13.9 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) Imm15 PF15590.1 CCF33905.1 - 0.93 8.6 3.9 3.7 6.7 1.7 2.2 2 0 0 2 2 2 0 Immunity protein 15 SDA1 PF05285.7 CCF33905.1 - 8 5.6 8.2 10 5.3 5.7 1.1 1 0 0 1 1 1 0 SDA1 Peptidase_S8 PF00082.17 CCF33906.1 - 5e-17 61.9 2.1 7.5e-17 61.3 1.4 1.2 1 0 0 1 1 1 1 Subtilase family zf-CCCH PF00642.19 CCF33907.1 - 9.3e-06 25.1 2.5 1.7e-05 24.3 1.7 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 CCF33907.1 - 0.25 11.4 3.1 0.44 10.6 2.2 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type Flavoprotein PF02441.14 CCF33908.1 - 3.7e-40 136.5 0.4 4.6e-40 136.2 0.3 1.1 1 0 0 1 1 1 1 Flavoprotein Mpp10 PF04006.7 CCF33909.1 - 1.2e-96 324.4 80.3 7.3e-86 288.8 20.5 2.1 1 1 1 2 2 2 2 Mpp10 protein EHN PF06441.7 CCF33910.1 - 1.4e-33 115.1 0.3 2.8e-33 114.2 0.1 1.6 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_6 PF12697.2 CCF33910.1 - 2.1e-09 37.5 0.4 7e-08 32.6 0.3 2.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF33910.1 - 0.0024 17.4 1.0 0.027 14.0 0.1 2.5 3 0 0 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF33910.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase family PP2C PF00481.16 CCF33912.1 - 1.6e-58 198.1 0.0 2.8e-58 197.2 0.0 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_4 PF12799.2 CCF33912.1 - 4.2e-47 157.0 63.9 1.5e-07 30.8 2.8 12.5 6 3 3 11 11 11 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CCF33912.1 - 2.2e-34 116.9 60.0 6.4e-09 35.4 2.1 9.9 4 3 8 12 12 12 10 Leucine rich repeat Guanylate_cyc PF00211.15 CCF33912.1 - 1.4e-31 109.3 0.0 3.4e-31 108.0 0.0 1.6 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain LRR_1 PF00560.28 CCF33912.1 - 7.6e-22 73.9 58.8 0.16 12.1 0.1 19.9 18 1 0 18 18 18 9 Leucine Rich Repeat Ad_cyc_g-alpha PF08509.6 CCF33912.1 - 5.9e-20 70.3 1.1 2.2e-19 68.5 0.8 2.1 1 0 0 1 1 1 1 Adenylate cyclase G-alpha binding domain LRR_7 PF13504.1 CCF33912.1 - 9e-15 52.2 43.9 2.3 8.7 0.0 17.5 19 0 0 19 19 19 3 Leucine rich repeat RA PF00788.18 CCF33912.1 - 9.9e-09 35.5 0.0 5.5e-08 33.1 0.0 2.3 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain LRR_6 PF13516.1 CCF33912.1 - 0.14 12.2 53.3 11 6.4 0.1 16.0 16 2 1 17 17 17 0 Leucine Rich repeat PTR2 PF00854.16 CCF33915.1 - 6.8e-34 117.2 8.0 1.1e-33 116.5 5.5 1.3 1 0 0 1 1 1 1 POT family GFA PF04828.9 CCF33916.1 - 3.2e-11 42.9 1.0 4.8e-11 42.4 0.7 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme E1_dh PF00676.15 CCF33918.1 - 5.7e-84 281.3 0.0 6.8e-84 281.1 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.16 CCF33918.1 - 0.00062 19.3 0.1 0.014 14.9 0.0 2.7 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.1 CCF33918.1 - 0.13 11.2 0.0 0.3 9.9 0.0 1.6 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase HECT PF00632.20 CCF33919.1 - 1.6e-82 277.2 0.0 2.4e-82 276.6 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HEAT PF02985.17 CCF33919.1 - 0.0048 16.8 0.8 2.1 8.6 0.0 4.6 4 0 0 4 4 4 1 HEAT repeat CLASP_N PF12348.3 CCF33919.1 - 0.019 14.3 1.2 0.069 12.4 0.0 2.4 3 0 0 3 3 3 0 CLASP N terminal Arm PF00514.18 CCF33919.1 - 0.024 14.4 8.1 8.1 6.4 0.0 6.7 7 1 1 8 8 8 0 Armadillo/beta-catenin-like repeat RRN3 PF05327.6 CCF33919.1 - 0.08 11.0 10.2 0.018 13.1 2.1 2.2 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 DRIM PF07539.7 CCF33919.1 - 0.082 12.3 0.6 0.31 10.4 0.0 2.3 2 0 0 2 2 2 0 Down-regulated in metastasis Sigma70_ner PF04546.8 CCF33919.1 - 5.8 6.4 23.9 0.38 10.3 4.3 2.9 2 0 0 2 2 2 0 Sigma-70, non-essential region Sec3_C PF09763.4 CCF33920.1 - 1.3e-233 777.2 1.5 1.7e-233 776.8 1.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.1 CCF33920.1 - 1.5e-30 104.9 0.0 3.1e-30 103.8 0.0 1.6 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Sec3_C_2 PF15278.1 CCF33920.1 - 0.0085 16.1 0.0 0.025 14.6 0.0 1.8 1 0 0 1 1 1 1 Sec3 exocyst complex subunit Vps52 PF04129.7 CCF33920.1 - 0.015 13.8 0.4 0.05 12.1 0.1 1.8 2 0 0 2 2 2 0 Vps52 / Sac2 family MCM PF00493.18 CCF33921.1 - 9.6e-139 461.7 0.0 1.3e-138 461.3 0.0 1.1 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 CCF33921.1 - 1.3e-26 93.4 0.0 5.6e-26 91.3 0.0 2.1 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 CCF33921.1 - 2e-05 23.8 0.0 0.0004 19.6 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 CCF33921.1 - 7.9e-05 22.4 0.0 0.0003 20.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 CCF33921.1 - 0.0017 17.9 0.0 0.006 16.1 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 CCF33921.1 - 0.1 12.0 0.2 3 7.2 0.0 2.8 3 0 0 3 3 3 0 Sigma-54 interaction domain Elf1 PF05129.8 CCF33921.1 - 0.36 10.5 2.4 0.53 10.0 0.9 1.8 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like Clat_adaptor_s PF01217.15 CCF33922.1 - 7.7e-17 61.3 0.2 4.3e-15 55.6 0.4 2.0 2 0 0 2 2 2 2 Clathrin adaptor complex small chain Sua5_yciO_yrdC PF01300.13 CCF33923.1 - 9.2e-53 178.1 0.0 1.4e-52 177.5 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.8 CCF33923.1 - 2.1e-25 89.2 0.0 4.4e-25 88.1 0.0 1.5 1 1 0 1 1 1 1 Putative GTP-binding controlling metal-binding DUF3806 PF12713.2 CCF33924.1 - 0.079 12.4 0.3 0.49 9.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3806) zf-RING_2 PF13639.1 CCF33925.1 - 5.7e-14 51.6 4.6 9.7e-14 50.9 3.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 CCF33925.1 - 9.4e-08 32.0 0.3 1.7e-07 31.2 0.2 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 CCF33925.1 - 8.8e-07 28.4 3.2 1.4e-06 27.8 2.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CCF33925.1 - 3e-06 27.1 5.1 4.9e-06 26.4 3.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF33925.1 - 7.1e-06 25.6 2.4 1.1e-05 25.0 1.7 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 CCF33925.1 - 4.4e-05 23.0 1.7 7.8e-05 22.2 1.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CCF33925.1 - 0.0026 17.5 0.8 0.0049 16.6 0.6 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 CCF33925.1 - 0.021 14.3 2.1 0.036 13.6 1.4 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.6 CCF33925.1 - 0.13 12.3 3.2 0.21 11.5 2.2 1.4 1 0 0 1 1 1 0 RING-like domain PHD PF00628.24 CCF33925.1 - 0.42 10.3 2.6 0.79 9.4 1.8 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING_6 PF14835.1 CCF33925.1 - 0.44 10.3 2.2 0.87 9.4 1.5 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_1 PF14446.1 CCF33925.1 - 1 9.1 3.1 1.6 8.4 0.6 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 FANCL_C PF11793.3 CCF33925.1 - 2 8.4 4.7 9.4 6.2 2.7 2.5 2 1 0 2 2 2 0 FANCL C-terminal domain DUF791 PF05631.9 CCF33927.1 - 1.6e-69 234.3 4.8 2.2e-69 233.8 3.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF791) MFS_1 PF07690.11 CCF33927.1 - 5.4e-23 81.2 28.5 5.4e-23 81.2 19.8 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF33927.1 - 2.9e-07 29.4 2.1 2.9e-07 29.4 1.5 3.1 2 1 1 3 3 3 2 Sugar (and other) transporter Reticulon PF02453.12 CCF33927.1 - 7.7 6.0 12.7 8.3 5.9 2.1 3.1 3 0 0 3 3 3 0 Reticulon DUF2678 PF10856.3 CCF33927.1 - 9.8 5.9 8.9 3.5 7.3 0.2 3.5 2 2 2 4 4 4 0 Protein of unknown function (DUF2678) Glyco_hydro_92 PF07971.7 CCF33928.1 - 0.00074 18.2 0.0 0.00085 18.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 zf-primase PF09329.6 CCF33929.1 - 2.6e-16 58.9 1.3 4.5e-16 58.1 0.9 1.4 1 0 0 1 1 1 1 Primase zinc finger tRNA_anti-codon PF01336.20 CCF33929.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain F-box-like PF12937.2 CCF33931.1 - 0.071 12.8 0.2 0.29 10.8 0.0 2.1 2 0 0 2 2 2 0 F-box-like MFS_1 PF07690.11 CCF33932.1 - 3.3e-32 111.5 58.5 5.2e-29 101.0 11.9 2.5 2 1 0 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF33932.1 - 1.5e-10 39.9 10.2 2.7e-10 39.0 7.1 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Pkinase PF00069.20 CCF33933.1 - 3.8e-35 121.2 0.0 4.8e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF33933.1 - 7.9e-14 51.3 0.0 1e-13 50.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CCF33933.1 - 0.028 14.1 0.0 0.48 10.1 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Peptidase_C13 PF01650.13 CCF33935.1 - 6.2e-41 140.3 0.3 8.3e-41 139.9 0.2 1.1 1 0 0 1 1 1 1 Peptidase C13 family MIS13 PF08202.6 CCF33935.1 - 0.013 14.5 0.1 0.019 14.0 0.1 1.2 1 0 0 1 1 1 0 Mis12-Mtw1 protein family Methyltransf_11 PF08241.7 CCF33936.1 - 1.2e-17 64.2 0.0 1.9e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF33936.1 - 1.7e-14 54.3 0.0 3.1e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF33936.1 - 6.3e-13 48.5 0.0 9.7e-13 47.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF33936.1 - 1.2e-12 48.1 0.0 2.2e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF33936.1 - 1.2e-12 48.0 0.0 2.2e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF33936.1 - 2.1e-11 43.8 0.1 3.2e-11 43.2 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF33936.1 - 3.9e-09 36.0 0.0 7.1e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.1 CCF33936.1 - 7.9e-09 35.4 0.0 1.1e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF33936.1 - 5.8e-08 32.1 0.0 7.1e-08 31.8 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.15 CCF33936.1 - 4.3e-06 26.0 0.0 5.6e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase CheR PF01739.13 CCF33936.1 - 0.00026 20.3 0.0 0.0016 17.7 0.0 2.1 1 1 1 2 2 2 1 CheR methyltransferase, SAM binding domain Methyltransf_PK PF05891.7 CCF33936.1 - 0.00027 20.3 0.0 0.00035 19.9 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase FmrO PF07091.6 CCF33936.1 - 0.001 18.1 0.0 0.0013 17.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) Methyltransf_16 PF10294.4 CCF33936.1 - 0.0035 16.8 0.0 0.0055 16.1 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase PCMT PF01135.14 CCF33936.1 - 0.01 15.4 0.0 0.013 15.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.13 CCF33936.1 - 0.024 13.8 0.0 0.034 13.3 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase DUF4203 PF13886.1 CCF33938.1 - 1.2e-30 106.6 27.0 1.2e-30 106.6 18.7 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4203) Glyco_hydro_3 PF00933.16 CCF33939.1 - 2.1e-06 26.9 0.0 2.1e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain zf-C2H2_4 PF13894.1 CCF33940.1 - 0.022 15.0 1.3 1.2 9.6 0.2 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Asp-B-Hydro_N PF05279.6 CCF33940.1 - 3.5 7.4 12.1 5 6.9 8.4 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region HR1 PF02185.11 CCF33941.1 - 0.035 13.8 0.1 0.18 11.6 0.0 2.3 2 0 0 2 2 2 0 Hr1 repeat V-SNARE PF05008.10 CCF33941.1 - 0.044 13.9 2.2 0.19 11.9 0.0 3.0 3 0 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus Lebercilin PF15619.1 CCF33941.1 - 0.61 9.4 4.0 0.13 11.6 0.2 1.7 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Fungal_lectin PF07938.7 CCF33944.1 - 5.8e-08 32.3 3.5 1.9e-07 30.7 2.2 1.7 1 1 0 1 1 1 1 Fungal fucose-specific lectin DUF2920 PF11144.3 CCF33945.1 - 0.15 11.0 0.0 0.21 10.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) KR PF08659.5 CCF33946.1 - 1.3e-19 70.5 0.0 2e-19 69.9 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 CCF33946.1 - 1.3e-18 67.4 0.2 3.7e-18 65.9 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N PF00107.21 CCF33946.1 - 1.5e-07 30.9 0.0 2.7e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF33946.1 - 2.4e-06 28.4 0.0 4e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AAA PF00004.24 CCF33947.1 - 1.2e-16 61.1 0.0 2.7e-16 59.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF33947.1 - 0.0025 17.8 2.4 0.0047 16.9 0.3 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.1 CCF33947.1 - 0.0045 16.7 0.2 0.013 15.2 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 CCF33947.1 - 0.0059 16.7 3.3 0.041 14.0 0.0 3.4 3 1 1 4 4 4 1 AAA domain KaiC PF06745.8 CCF33947.1 - 0.0065 15.6 0.4 0.015 14.4 0.3 1.6 1 0 0 1 1 1 1 KaiC AAA_5 PF07728.9 CCF33947.1 - 0.03 14.0 0.0 0.085 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.1 CCF33947.1 - 0.035 13.6 0.0 0.074 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 CCF33947.1 - 0.058 13.2 0.0 0.19 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 CCF33947.1 - 0.075 12.5 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_17 PF13207.1 CCF33947.1 - 0.075 13.8 3.8 0.44 11.3 1.2 3.1 2 1 0 2 2 2 0 AAA domain PRD PF00874.15 CCF33947.1 - 0.21 11.7 1.7 12 6.0 0.1 2.5 2 0 0 2 2 2 0 PRD domain NmrA PF05368.8 CCF33948.1 - 5.2e-22 78.2 0.0 8.2e-22 77.6 0.0 1.3 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF33948.1 - 4.6e-11 43.0 0.0 8.7e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 CCF33948.1 - 0.0042 15.8 0.0 0.0071 15.0 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Caps_synth PF05704.7 CCF33952.1 - 3.2e-16 59.3 0.5 4.5e-16 58.8 0.4 1.2 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.10 CCF33952.1 - 3.5e-05 24.1 0.0 5.9e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 CCF33952.1 - 0.12 10.7 0.0 0.18 10.2 0.0 1.1 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain DUF1768 PF08719.6 CCF33953.1 - 6.1e-47 159.2 0.0 7.2e-47 159.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Glyco_hydro_79n PF03662.9 CCF33953.1 - 0.063 11.8 0.0 0.087 11.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 79, N-terminal domain GET2 PF08690.5 CCF33954.1 - 5.1e-08 32.5 5.2 9.9e-06 25.0 0.5 3.5 2 1 0 2 2 2 2 GET complex subunit GET2 SRA1 PF07304.6 CCF33955.1 - 1.1e-09 38.2 10.6 3.9e-09 36.4 7.3 2.0 1 1 0 1 1 1 1 Steroid receptor RNA activator (SRA1) Prp18 PF02840.10 CCF33955.1 - 0.0095 15.7 0.3 0.087 12.6 0.1 2.0 1 1 1 2 2 2 1 Prp18 domain PAT1 PF09770.4 CCF33955.1 - 4.7 5.3 16.2 4.6 5.3 11.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ABC_tran PF00005.22 CCF33956.1 - 3.8e-46 156.7 0.0 7.9e-27 94.2 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 CCF33956.1 - 1.9e-30 106.1 37.8 6.7e-23 81.4 10.1 2.5 3 0 0 3 3 3 2 ABC transporter transmembrane region AAA_21 PF13304.1 CCF33956.1 - 3.5e-11 43.6 0.0 0.0053 16.7 0.0 4.2 3 1 0 3 3 3 3 AAA domain SMC_N PF02463.14 CCF33956.1 - 2.1e-09 36.9 9.6 0.007 15.6 0.0 4.6 4 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 CCF33956.1 - 9.8e-08 31.4 0.6 0.00078 18.9 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.13 CCF33956.1 - 1.2e-07 31.3 0.3 0.018 14.5 0.0 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family Miro PF08477.8 CCF33956.1 - 8.5e-07 29.4 0.2 0.0029 18.0 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein AAA_25 PF13481.1 CCF33956.1 - 1.1e-06 28.2 2.4 0.0087 15.4 0.0 3.3 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.1 CCF33956.1 - 1.2e-06 28.7 0.1 0.0011 19.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.1 CCF33956.1 - 1.6e-05 24.7 0.2 0.29 11.0 0.0 3.0 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit DUF258 PF03193.11 CCF33956.1 - 2.9e-05 23.3 0.1 0.086 12.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_23 PF13476.1 CCF33956.1 - 6e-05 23.4 0.0 0.034 14.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 CCF33956.1 - 0.00017 21.1 0.6 0.48 9.8 0.1 2.4 2 0 0 2 2 2 2 AAA-like domain MMR_HSR1 PF01926.18 CCF33956.1 - 0.00084 19.2 0.0 0.43 10.5 0.0 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase MobB PF03205.9 CCF33956.1 - 0.0013 18.4 0.3 0.56 9.9 0.1 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 CCF33956.1 - 0.0015 18.5 0.0 2.7 7.9 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.1 CCF33956.1 - 0.0037 17.1 0.3 2.6 7.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CCF33956.1 - 0.0038 16.9 2.0 1.8 8.4 0.1 4.2 4 0 0 4 4 3 1 Part of AAA domain cobW PF02492.14 CCF33956.1 - 0.0045 16.4 1.2 2.1 7.7 0.1 2.4 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.7 CCF33956.1 - 0.0054 15.8 0.0 0.75 8.8 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin Dynamin_N PF00350.18 CCF33956.1 - 0.006 16.4 5.2 0.015 15.1 0.1 2.6 3 0 0 3 3 2 1 Dynamin family T2SE PF00437.15 CCF33956.1 - 0.006 15.5 0.0 1.3 7.9 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_17 PF13207.1 CCF33956.1 - 0.012 16.3 0.0 3.8 8.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 CCF33956.1 - 0.018 14.6 0.0 6.5 6.3 0.0 2.8 2 0 0 2 2 2 0 NACHT domain Arch_ATPase PF01637.13 CCF33956.1 - 0.023 14.3 0.0 4.3 6.9 0.0 2.3 2 0 0 2 2 2 0 Archaeal ATPase DUF87 PF01935.12 CCF33956.1 - 0.031 14.0 1.8 0.66 9.7 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF87 Pox_A32 PF04665.7 CCF33956.1 - 0.065 12.5 0.2 1.1 8.4 0.0 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein NTPase_1 PF03266.10 CCF33956.1 - 0.066 12.9 1.0 0.81 9.3 0.0 2.8 3 0 0 3 3 3 0 NTPase ATP_bind_1 PF03029.12 CCF33956.1 - 0.084 12.3 4.0 4.3 6.8 0.1 3.3 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.1 CCF33956.1 - 0.11 12.0 0.9 3 7.3 0.0 2.6 3 0 0 3 3 2 0 AAA domain AAA_18 PF13238.1 CCF33956.1 - 0.23 11.7 0.1 3.3 8.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 CCF33956.1 - 0.36 11.0 1.8 12 6.1 0.0 3.2 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) PIG-L PF02585.12 CCF33957.1 - 1.3e-24 87.1 0.0 2.3e-24 86.3 0.0 1.4 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase ATP13 PF12921.2 CCF33958.1 - 2.5e-13 49.4 2.6 1.1e-12 47.3 0.1 2.2 2 0 0 2 2 2 1 Mitochondrial ATPase expression LSM PF01423.17 CCF33959.1 - 2e-13 49.6 0.4 2.8e-13 49.2 0.3 1.2 1 0 0 1 1 1 1 LSM domain SR-25 PF10500.4 CCF33961.1 - 0.0022 17.5 13.1 0.0025 17.3 9.1 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF755 PF05501.6 CCF33961.1 - 0.018 15.1 15.8 0.021 14.8 10.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Collagen PF01391.13 CCF33961.1 - 0.024 14.1 1.2 0.04 13.4 0.9 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) BLVR PF06375.6 CCF33961.1 - 1.2 8.9 9.8 1.4 8.7 6.8 1.2 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) PNP_UDP_1 PF01048.15 CCF33962.1 - 4.7e-06 25.7 0.0 5.7e-06 25.4 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily AAA_22 PF13401.1 CCF33963.1 - 3.3e-06 27.2 0.0 9.6e-06 25.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 CCF33963.1 - 0.00014 21.5 0.0 0.00061 19.4 0.0 2.0 2 0 0 2 2 2 1 NACHT domain Glyco_hydro_3_C PF01915.17 CCF33963.1 - 0.054 13.0 0.2 0.093 12.2 0.1 1.4 1 1 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain AAA_16 PF13191.1 CCF33963.1 - 0.099 12.6 4.2 3.5 7.5 0.1 2.8 2 1 1 3 3 3 0 AAA ATPase domain NB-ARC PF00931.17 CCF33963.1 - 0.16 10.7 0.0 7.6 5.2 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain MFS_1 PF07690.11 CCF33964.1 - 4e-08 32.3 17.3 4e-08 32.3 12.0 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Colicin_V PF02674.11 CCF33964.1 - 1.1 9.1 12.9 0.088 12.6 3.4 2.4 1 1 0 2 2 2 0 Colicin V production protein GtrA PF04138.9 CCF33964.1 - 2.3 8.1 12.9 0.15 12.0 3.6 2.3 1 1 1 2 2 2 0 GtrA-like protein Methyltransf_15 PF09445.5 CCF33966.1 - 2.2e-45 154.1 0.0 2.9e-45 153.7 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_26 PF13659.1 CCF33966.1 - 2e-07 31.0 0.0 3.3e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 CCF33966.1 - 8.1e-06 25.5 0.0 8.9e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_18 PF12847.2 CCF33966.1 - 1.5e-05 25.5 0.0 2.4e-05 24.8 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 CCF33966.1 - 8.7e-05 22.1 0.0 0.00021 20.9 0.0 1.6 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Cons_hypoth95 PF03602.10 CCF33966.1 - 0.00025 20.4 0.0 0.00041 19.7 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 RrnaAD PF00398.15 CCF33966.1 - 0.13 11.2 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase MTS PF05175.9 CCF33966.1 - 0.17 11.2 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Dopey_N PF04118.9 CCF33967.1 - 4.8e-15 55.1 0.0 1.7e-14 53.2 0.0 2.0 2 0 0 2 2 2 1 Dopey, N-terminal 4HBT_2 PF13279.1 CCF33969.1 - 2.7e-20 73.0 0.1 3.9e-20 72.4 0.1 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.17 CCF33969.1 - 0.016 15.2 0.0 0.048 13.7 0.0 1.8 1 0 0 1 1 1 0 Thioesterase superfamily CoA_transf_3 PF02515.12 CCF33970.1 - 2.6e-62 209.4 0.0 3.8e-62 208.9 0.0 1.3 1 0 0 1 1 1 1 CoA-transferase family III Acyl-CoA_dh_1 PF00441.19 CCF33971.1 - 1.5e-31 109.5 2.2 2.7e-31 108.6 1.5 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 CCF33971.1 - 2.7e-19 69.8 0.2 5.6e-19 68.7 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 CCF33971.1 - 1.2e-15 57.9 3.3 1.2e-15 57.9 2.3 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 CCF33971.1 - 2.5e-15 55.7 0.1 5.9e-15 54.5 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Sugar_tr PF00083.19 CCF33972.1 - 3.3e-43 147.9 6.6 3.7e-43 147.7 4.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF33972.1 - 2.6e-08 32.9 19.2 2.7e-08 32.9 12.8 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily PAN_4 PF14295.1 CCF33973.1 - 0.076 12.7 7.6 0.16 11.7 0.6 3.0 2 0 0 2 2 2 0 PAN domain Tubulin PF00091.20 CCF33974.1 - 7e-26 91.3 0.0 7.7e-26 91.2 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain APH PF01636.18 CCF33975.1 - 6.7e-11 42.3 0.0 8.4e-11 42.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CCF33975.1 - 2.8e-07 30.3 0.1 4e-07 29.8 0.1 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.15 CCF33975.1 - 1.6e-06 27.5 0.0 2.4e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Kdo PF06293.9 CCF33975.1 - 0.025 13.6 0.1 1.7 7.6 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Fructosamin_kin PF03881.9 CCF33975.1 - 0.038 12.9 0.0 0.061 12.2 0.0 1.3 1 0 0 1 1 1 0 Fructosamine kinase DUF1687 PF07955.6 CCF33975.1 - 0.11 12.4 0.0 0.28 11.1 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1687) DUF1679 PF07914.6 CCF33975.1 - 0.14 10.7 0.0 0.19 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) DUF2392 PF10288.4 CCF33976.1 - 2.6e-18 66.3 0.0 1.5e-16 60.6 0.0 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF2392) DZR PF12773.2 CCF33976.1 - 0.59 10.0 5.5 9.1 6.1 0.8 2.4 2 0 0 2 2 2 0 Double zinc ribbon zf-FPG_IleRS PF06827.9 CCF33976.1 - 2 8.1 8.8 2.3 7.9 4.4 2.2 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS Mito_carr PF00153.22 CCF33977.1 - 1.3e-13 50.4 0.0 1.4e-13 50.3 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein Lgl_C PF08596.5 CCF33978.1 - 9.2e-115 383.2 0.0 2.8e-114 381.6 0.0 1.8 2 0 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.27 CCF33978.1 - 0.00067 19.4 0.7 0.13 12.1 0.0 3.6 3 0 0 3 3 3 1 WD domain, G-beta repeat Apc4_WD40 PF12894.2 CCF33978.1 - 0.041 13.3 0.0 7.4 6.1 0.0 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain SAG PF04092.8 CCF33979.1 - 0.011 16.1 3.4 0.037 14.3 2.3 2.0 1 1 0 1 1 1 0 SRS domain DUF4446 PF14584.1 CCF33979.1 - 0.034 13.9 0.2 0.034 13.9 0.1 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Pox_Ag35 PF03286.9 CCF33979.1 - 0.15 11.5 2.1 0.2 11.1 1.4 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Sec10 PF07393.6 CCF33979.1 - 0.41 8.7 3.1 0.5 8.4 2.1 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec10 PAP1 PF08601.5 CCF33982.1 - 1.3e-54 186.2 11.2 1.3e-54 186.2 7.8 2.8 1 1 2 3 3 3 1 Transcription factor PAP1 bZIP_1 PF00170.16 CCF33982.1 - 6e-10 38.9 12.2 1.6e-09 37.5 8.5 1.7 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 CCF33982.1 - 0.0017 18.1 13.0 0.0086 15.8 9.0 2.1 1 1 0 1 1 1 1 Basic region leucine zipper Adeno_PIX PF03955.9 CCF33982.1 - 0.0065 16.9 0.9 0.024 15.1 0.6 2.0 1 0 0 1 1 1 1 Adenovirus hexon-associated protein (IX) DUF904 PF06005.7 CCF33982.1 - 0.011 15.9 3.3 0.027 14.7 2.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF904) DUF812 PF05667.6 CCF33982.1 - 0.012 14.1 6.5 0.019 13.5 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) APG6 PF04111.7 CCF33982.1 - 0.028 13.4 2.9 0.05 12.6 2.0 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 GAS PF13851.1 CCF33982.1 - 0.041 13.0 7.6 0.079 12.1 5.2 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Tropomyosin PF00261.15 CCF33982.1 - 0.066 12.2 9.8 0.11 11.5 6.8 1.2 1 0 0 1 1 1 0 Tropomyosin Med30 PF11315.3 CCF33982.1 - 0.075 13.1 0.7 13 5.9 0.0 2.4 2 0 0 2 2 2 0 Mediator complex subunit 30 bZIP_Maf PF03131.12 CCF33982.1 - 0.077 13.3 8.8 0.16 12.2 6.1 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF972 PF06156.8 CCF33982.1 - 0.081 13.2 3.8 0.05 13.9 1.0 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF972) DOG1 PF14144.1 CCF33982.1 - 0.085 12.9 1.0 0.21 11.6 0.7 1.7 1 0 0 1 1 1 0 Seed dormancy control TMCO5 PF14992.1 CCF33982.1 - 0.09 11.9 2.7 0.14 11.2 1.9 1.2 1 0 0 1 1 1 0 TMCO5 family ALIX_LYPXL_bnd PF13949.1 CCF33982.1 - 0.094 11.6 8.4 0.036 13.0 3.8 1.7 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV HrpB7 PF09486.5 CCF33982.1 - 0.11 12.3 5.6 0.22 11.4 3.9 1.4 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) DUF4200 PF13863.1 CCF33982.1 - 0.17 11.8 11.6 0.33 10.9 8.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) SlyX PF04102.7 CCF33982.1 - 0.21 11.9 5.8 0.1 12.9 1.4 2.2 2 0 0 2 2 2 0 SlyX WXG100 PF06013.7 CCF33982.1 - 0.26 11.3 4.1 0.66 10.0 0.4 2.5 2 0 0 2 2 2 0 Proteins of 100 residues with WXG FlaC_arch PF05377.6 CCF33982.1 - 0.32 10.9 1.8 0.63 9.9 1.2 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) IncA PF04156.9 CCF33982.1 - 0.5 9.9 7.3 0.88 9.1 5.1 1.3 1 0 0 1 1 1 0 IncA protein EAP30 PF04157.11 CCF33982.1 - 0.66 9.0 5.5 3.3 6.8 4.2 1.7 2 0 0 2 2 2 0 EAP30/Vps36 family Jnk-SapK_ap_N PF09744.4 CCF33982.1 - 0.98 9.3 7.2 1.8 8.5 5.0 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Snapin_Pallidin PF14712.1 CCF33982.1 - 1 9.7 6.2 0.12 12.7 0.8 2.0 2 0 0 2 2 1 0 Snapin/Pallidin NAM-associated PF14303.1 CCF33982.1 - 1.6 9.0 16.6 4.9 7.4 11.5 1.8 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain IFT57 PF10498.4 CCF33982.1 - 1.6 7.3 8.0 0.19 10.4 1.9 2.2 3 0 0 3 3 3 0 Intra-flagellar transport protein 57 Prefoldin_2 PF01920.15 CCF33982.1 - 1.9 8.2 8.9 0.74 9.5 3.9 1.9 2 0 0 2 2 2 0 Prefoldin subunit CDC45 PF02724.9 CCF33982.1 - 4.9 5.0 9.8 7.1 4.5 6.8 1.1 1 0 0 1 1 1 0 CDC45-like protein XhlA PF10779.4 CCF33982.1 - 6.9 6.6 5.8 15 5.6 4.0 1.5 1 0 0 1 1 1 0 Haemolysin XhlA Sugar_tr PF00083.19 CCF33983.1 - 2.3e-118 395.6 19.8 2.7e-118 395.4 13.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF33983.1 - 1.8e-25 89.4 54.4 1.4e-23 83.2 16.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Abhydrolase_4 PF08386.5 CCF33984.1 - 9.6e-13 47.9 0.0 2e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_6 PF12697.2 CCF33984.1 - 3.3e-08 33.6 0.0 1.3e-07 31.7 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF33984.1 - 4.8e-05 23.0 0.0 8.8e-05 22.1 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Fungal_trans PF04082.13 CCF33985.1 - 4.8e-15 55.1 0.0 7.3e-15 54.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF33985.1 - 5.9e-08 32.4 7.1 1.1e-07 31.6 4.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CGI-121 PF08617.5 CCF33986.1 - 3e-51 173.2 0.0 3.5e-51 173.0 0.0 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 DUF2860 PF11059.3 CCF33986.1 - 0.044 12.8 0.0 0.057 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2860) Pro_dh PF01619.13 CCF33987.1 - 2.5e-37 128.5 0.0 3.2e-37 128.2 0.0 1.2 1 0 0 1 1 1 1 Proline dehydrogenase UDPGT PF00201.13 CCF33989.1 - 2.1e-10 39.7 0.0 2.9e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_28 PF03033.15 CCF33989.1 - 0.091 12.5 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain Abhydrolase_6 PF12697.2 CCF33990.1 - 1.3e-32 113.4 1.0 2.3e-32 112.7 0.7 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF33990.1 - 3.1e-16 59.6 0.0 2.3e-14 53.5 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF33990.1 - 4.1e-13 49.3 0.0 1.8e-12 47.2 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CCF33990.1 - 4.4e-06 26.4 0.0 8.3e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase AXE1 PF05448.7 CCF33990.1 - 0.056 11.9 0.0 0.14 10.6 0.0 1.6 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Ndr PF03096.9 CCF33990.1 - 0.15 10.5 0.0 0.22 9.9 0.0 1.3 1 0 0 1 1 1 0 Ndr family Cys_Met_Meta_PP PF01053.15 CCF33991.1 - 3.4e-149 496.3 0.0 3.9e-149 496.1 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 CCF33991.1 - 2.9e-15 56.1 0.3 4.8e-15 55.4 0.2 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 CCF33991.1 - 9.1e-11 41.2 0.0 1.5e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 CCF33991.1 - 2.7e-09 36.6 0.0 5.2e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 CCF33991.1 - 5e-08 32.0 0.4 1.4e-07 30.5 0.4 1.7 2 1 0 2 2 2 1 Aminotransferase class-V Met_gamma_lyase PF06838.6 CCF33991.1 - 0.00015 20.2 0.1 0.00019 19.8 0.1 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase SLA_LP_auto_ag PF05889.8 CCF33991.1 - 0.009 14.5 0.0 0.013 14.0 0.0 1.1 1 0 0 1 1 1 1 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) GDC-P PF02347.11 CCF33991.1 - 0.025 13.2 0.1 0.036 12.7 0.1 1.1 1 0 0 1 1 1 0 Glycine cleavage system P-protein CPSase_L_D2 PF02786.12 CCF33991.1 - 0.12 11.6 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain DUF2012 PF09430.5 CCF33992.1 - 9.3e-21 73.9 0.0 1.4e-20 73.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) G6PD_C PF02781.11 CCF33996.1 - 8.5e-126 418.7 0.0 1e-125 418.4 0.0 1.0 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain Med14 PF08638.6 CCF33997.1 - 7.5e-70 234.1 0.0 1.6e-69 233.1 0.0 1.6 1 0 0 1 1 1 1 Mediator complex subunit MED14 Oxysterol_BP PF01237.13 CCF33999.1 - 1.5e-87 293.4 0.0 1.9e-87 293.0 0.0 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein zf-CCCH PF00642.19 CCF34000.1 - 1.7e-08 33.9 18.1 4.6e-07 29.3 1.6 3.2 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_5 PF13893.1 CCF34000.1 - 0.00025 20.8 0.0 0.00039 20.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CCF34000.1 - 0.01 15.4 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tachystatin_B PF11478.3 CCF34000.1 - 4.6 7.0 9.0 0.4 10.4 1.3 2.6 3 0 0 3 3 3 0 Antimicrobial chitin binding protein tachystatin B Lactonase PF10282.4 CCF34002.1 - 9.9e-88 294.4 0.0 1.2e-87 294.2 0.0 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller PEMT PF04191.8 CCF34003.1 - 0.0065 16.5 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Phospholipid methyltransferase Adaptin_binding PF10199.4 CCF34004.1 - 4.1e-19 69.2 6.0 6.2e-19 68.6 4.2 1.3 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Alpha_GJ PF03229.8 CCF34004.1 - 0.042 14.1 4.1 0.087 13.1 2.8 1.5 1 0 0 1 1 1 0 Alphavirus glycoprotein J Herpes_U47 PF05467.6 CCF34004.1 - 0.17 9.6 3.0 0.23 9.2 2.1 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein U47 FixP_N PF14715.1 CCF34005.1 - 6.2 6.2 7.6 13 5.3 5.3 1.4 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Esterase_phd PF10503.4 CCF34006.1 - 2e-22 79.5 0.2 2.7e-22 79.0 0.1 1.1 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.16 CCF34006.1 - 2.4e-10 39.9 1.0 3.2e-10 39.5 0.7 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CCF34006.1 - 2.7e-07 30.4 0.1 3.4e-07 30.0 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S10 PF00450.17 CCF34006.1 - 3.4e-05 23.1 0.6 4.5e-05 22.7 0.4 1.3 1 1 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 CCF34006.1 - 6.8e-05 22.8 0.0 0.0001 22.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 CCF34006.1 - 0.0004 19.8 0.5 0.00059 19.3 0.4 1.2 1 0 0 1 1 1 1 Putative esterase Abhydrolase_1 PF00561.15 CCF34006.1 - 0.00087 18.9 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 CCF34006.1 - 0.00098 17.9 1.1 0.011 14.4 0.1 2.1 2 0 0 2 2 2 1 Carboxylesterase family BAAT_C PF08840.6 CCF34006.1 - 0.0056 16.4 0.1 0.0088 15.7 0.1 1.3 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.13 CCF34006.1 - 0.043 13.0 0.3 0.072 12.3 0.1 1.4 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_2 PF02230.11 CCF34006.1 - 0.063 12.7 0.0 0.15 11.4 0.0 1.6 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.8 CCF34006.1 - 0.066 12.7 0.0 0.087 12.3 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold adh_short_C2 PF13561.1 CCF34007.1 - 1.2e-19 71.0 0.0 1.5e-19 70.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF34007.1 - 3.7e-12 46.4 1.2 5.3e-12 45.9 0.9 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF34007.1 - 0.0088 15.7 0.9 0.02 14.5 0.6 1.5 1 1 0 1 1 1 1 KR domain ECH PF00378.15 CCF34008.1 - 5.4e-22 78.1 0.0 7.5e-22 77.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family adh_short_C2 PF13561.1 CCF34009.1 - 4.4e-29 101.9 0.7 5.4e-29 101.6 0.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF34009.1 - 3.2e-27 95.5 0.2 4e-27 95.1 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF34009.1 - 2.1e-14 53.5 0.2 3e-14 53.1 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF34009.1 - 0.0019 17.6 0.5 0.0032 16.9 0.4 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Ras_bdg_2 PF14847.1 CCF34009.1 - 0.0046 16.8 0.1 0.008 16.0 0.1 1.4 1 0 0 1 1 1 1 Ras-binding domain of Byr2 NAD_Gly3P_dh_N PF01210.18 CCF34009.1 - 0.075 12.7 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Alpha-L-AF_C PF06964.7 CCF34011.1 - 5.9e-27 94.5 0.0 1e-26 93.8 0.0 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminus ADH_zinc_N PF00107.21 CCF34012.1 - 5.2e-27 93.9 1.2 8.3e-27 93.3 0.8 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF34012.1 - 9.4e-17 62.0 0.4 3e-16 60.4 0.0 2.0 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF34012.1 - 8.3e-13 48.0 0.0 1.9e-12 46.9 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.13 CCF34012.1 - 0.001 19.0 0.0 0.0022 17.9 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain Peripla_BP_6 PF13458.1 CCF34012.1 - 0.0061 15.9 1.1 0.23 10.7 0.2 2.6 2 1 1 3 3 3 1 Periplasmic binding protein AlaDh_PNT_C PF01262.16 CCF34012.1 - 0.014 14.9 0.1 0.026 14.0 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Mito_carr PF00153.22 CCF34014.1 - 3.6e-56 186.8 6.2 4.7e-23 80.7 0.2 4.0 4 0 0 4 4 4 4 Mitochondrial carrier protein DND1_DSRM PF14709.1 CCF34014.1 - 0.08 13.2 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 DUF3014 PF11219.3 CCF34015.1 - 0.026 14.4 0.1 0.028 14.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3014) DUF2370 PF10176.4 CCF34016.1 - 1.1e-83 280.1 0.1 1.1e-83 280.1 0.0 2.1 1 1 2 3 3 3 1 Protein of unknown function (DUF2370) PCMT PF01135.14 CCF34017.1 - 5.5e-55 186.1 0.0 7e-55 185.8 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.2 CCF34017.1 - 1.7e-06 28.5 0.0 2.6e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF34017.1 - 1.8e-05 24.3 0.0 2.6e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 CCF34017.1 - 0.00047 19.8 0.0 0.00074 19.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF34017.1 - 0.00051 20.0 0.0 0.00081 19.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF34017.1 - 0.0069 15.7 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.1 CCF34017.1 - 0.0074 16.0 0.0 0.0097 15.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 CCF34017.1 - 0.061 12.3 0.0 0.086 11.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Ubie_methyltran PF01209.13 CCF34017.1 - 0.065 12.3 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family COesterase PF00135.23 CCF34018.1 - 2.7e-75 254.0 0.0 4.9e-75 253.2 0.0 1.3 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF34018.1 - 3.6e-07 29.9 0.2 1.9e-06 27.6 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF34018.1 - 0.034 13.9 0.1 0.054 13.2 0.1 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF34018.1 - 0.073 12.2 0.3 0.15 11.2 0.2 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family FAD_binding_4 PF01565.18 CCF34019.1 - 9.2e-23 80.2 0.0 1.7e-22 79.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 CCF34019.1 - 0.00017 21.3 0.2 0.00039 20.2 0.1 1.6 1 0 0 1 1 1 1 Berberine and berberine like BNR PF02012.15 CCF34020.1 - 1.4e-05 24.1 3.4 5.3 7.2 0.0 5.4 5 0 0 5 5 5 3 BNR/Asp-box repeat NPR2 PF06218.6 CCF34021.1 - 4.5e-64 216.7 0.0 3.8e-47 160.9 0.0 2.0 1 1 1 2 2 2 2 Nitrogen permease regulator 2 tRNA-synt_1b PF00579.20 CCF34022.1 - 5.3e-79 265.3 0.0 7.2e-79 264.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) CybS PF05328.7 CCF34023.1 - 7.6e-48 161.4 0.0 9.8e-48 161.1 0.0 1.1 1 0 0 1 1 1 1 CybS Sdh_cyt PF01127.17 CCF34023.1 - 0.016 15.0 0.4 0.31 10.8 0.3 2.1 1 1 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF3419 PF11899.3 CCF34024.1 - 4.8e-157 522.5 0.0 6.5e-157 522.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_23 PF13489.1 CCF34024.1 - 2.9e-14 53.1 0.0 1.3e-12 47.7 0.0 2.7 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF34024.1 - 6.5e-10 39.5 0.0 7.5e-09 36.1 0.0 2.4 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF34024.1 - 2.5e-09 37.1 0.0 1.4e-05 25.1 0.0 3.9 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF34024.1 - 8.8e-09 35.1 0.0 3e-07 30.1 0.0 2.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF34024.1 - 9.6e-09 35.6 0.0 5.4e-08 33.2 0.0 2.3 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF34024.1 - 8.5e-08 32.5 0.0 0.0015 18.9 0.0 4.2 4 0 0 4 4 4 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF34024.1 - 3.6e-07 29.5 0.0 0.0014 17.7 0.0 2.7 3 0 0 3 3 3 2 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 CCF34024.1 - 0.00012 22.3 0.0 0.0003 21.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 CCF34024.1 - 0.00068 19.2 0.0 0.0017 17.9 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_28 PF02636.12 CCF34024.1 - 0.13 11.6 0.0 0.28 10.5 0.0 1.6 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_32 PF13679.1 CCF34024.1 - 0.16 11.6 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.12 CCF34024.1 - 0.18 10.8 0.0 1.5 7.8 0.0 2.3 3 0 0 3 3 3 0 Putative methyltransferase HAD_2 PF13419.1 CCF34025.1 - 2e-24 86.7 0.1 2.6e-24 86.4 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CCF34025.1 - 0.023 15.1 0.0 0.053 13.9 0.0 1.7 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Tachystatin_B PF11478.3 CCF34025.1 - 0.027 14.1 1.8 0.037 13.7 0.2 2.0 2 0 0 2 2 2 0 Antimicrobial chitin binding protein tachystatin B Aminotran_3 PF00202.16 CCF34026.1 - 3.4e-99 331.9 0.0 4e-99 331.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 CCF34026.1 - 0.04 12.8 0.0 0.058 12.3 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II Aldedh PF00171.17 CCF34027.1 - 2.4e-159 530.6 0.1 2.7e-159 530.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 CCF34027.1 - 0.033 13.4 0.0 3 7.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) DUF126 PF01989.11 CCF34027.1 - 0.85 9.3 3.7 16 5.2 0.2 2.7 1 1 1 2 2 2 0 Protein of unknown function DUF126 DUF1620 PF07774.8 CCF34028.1 - 1.2e-68 230.6 0.0 2e-68 229.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1620) PQQ_2 PF13360.1 CCF34028.1 - 3.8e-14 52.7 8.1 3.3e-12 46.3 1.4 2.8 2 0 0 2 2 2 2 PQQ-like domain PQQ PF01011.16 CCF34028.1 - 0.018 14.5 2.4 10 5.8 0.0 4.5 4 0 0 4 4 4 0 PQQ enzyme repeat UPF0231 PF06062.6 CCF34028.1 - 0.097 12.5 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0231) Isy1 PF06246.7 CCF34029.1 - 2.3e-88 295.9 0.3 3.4e-88 295.3 0.2 1.2 1 0 0 1 1 1 1 Isy1-like splicing family YolD PF08863.5 CCF34029.1 - 0.058 13.2 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 YolD-like protein CCDC-167 PF15188.1 CCF34029.1 - 0.1 12.5 0.1 0.32 10.9 0.0 1.8 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Ribosomal_S14 PF00253.16 CCF34030.1 - 4e-15 54.9 1.4 5.6e-15 54.4 0.5 1.6 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e Fringe PF02434.11 CCF34031.1 - 5.1e-07 29.1 0.0 1e-06 28.1 0.0 1.6 1 1 0 1 1 1 1 Fringe-like DUF604 PF04646.7 CCF34031.1 - 2.3e-06 27.0 0.0 4e-05 22.9 0.0 2.2 1 1 0 1 1 1 1 Protein of unknown function, DUF604 BRO1 PF03097.13 CCF34032.1 - 2e-109 365.8 0.0 3.1e-109 365.1 0.0 1.3 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 CCF34032.1 - 1.6e-81 273.5 2.5 1.6e-81 273.5 1.7 1.6 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV A_deaminase PF00962.17 CCF34032.1 - 0.034 13.0 0.0 0.052 12.4 0.0 1.4 1 0 0 1 1 1 0 Adenosine/AMP deaminase R3H-assoc PF13902.1 CCF34032.1 - 0.16 11.9 5.3 0.033 14.1 0.9 2.0 2 0 0 2 2 2 0 R3H-associated N-terminal domain Seryl_tRNA_N PF02403.17 CCF34032.1 - 2.6 8.1 9.0 1.6 8.7 1.5 3.3 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Aldo_ket_red PF00248.16 CCF34033.1 - 3.7e-13 48.9 0.0 4.3e-13 48.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Dynactin_p62 PF05502.8 CCF34034.1 - 6.9e-160 532.9 0.0 8.7e-160 532.6 0.0 1.0 1 0 0 1 1 1 1 Dynactin p62 family DUF4519 PF15012.1 CCF34034.1 - 2.8 7.9 8.2 0.12 12.3 1.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Ribosomal_S7e PF01251.13 CCF34035.1 - 3.4e-83 277.7 0.3 3.8e-83 277.6 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e DUF4448 PF14610.1 CCF34036.1 - 2.5e-28 98.8 0.0 3.4e-28 98.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Nucleoporin_N PF08801.6 CCF34038.1 - 1.9e-81 274.0 0.0 2.6e-81 273.5 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.9 CCF34038.1 - 2.2e-81 274.1 21.1 3.2e-81 273.6 14.6 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Neuropep_like PF15161.1 CCF34038.1 - 0.11 11.9 0.3 0.25 10.8 0.2 1.5 1 0 0 1 1 1 0 Neuropeptide-like DUF410 PF04190.8 CCF34039.1 - 5.2e-28 98.3 0.0 6.7e-28 97.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) NmrA PF05368.8 CCF34041.1 - 1.7e-17 63.5 0.0 2.1e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF34041.1 - 2.2e-11 44.0 0.0 3.8e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding DapB_N PF01113.15 CCF34041.1 - 0.0014 18.4 0.0 0.0031 17.4 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Saccharop_dh PF03435.13 CCF34041.1 - 0.0022 17.0 0.0 0.0047 15.9 0.0 1.5 2 0 0 2 2 2 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 CCF34041.1 - 0.0071 16.4 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.19 CCF34041.1 - 0.041 14.1 0.0 0.082 13.2 0.0 1.6 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.7 CCF34041.1 - 0.13 11.1 0.0 0.21 10.4 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein Porin_3 PF01459.17 CCF34042.1 - 2.3e-86 289.5 0.4 2.7e-86 289.2 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic porin CWC25 PF12542.3 CCF34043.1 - 1.4e-24 86.3 0.4 1.4e-24 86.3 0.2 3.7 4 1 0 4 4 4 1 Pre-mRNA splicing factor Ras PF00071.17 CCF34044.1 - 2.2e-54 183.1 0.0 2.6e-54 182.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF34044.1 - 3.7e-16 59.7 0.0 5e-16 59.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CCF34044.1 - 9.5e-10 37.9 0.0 1.5e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CCF34044.1 - 0.00019 20.6 0.0 0.00024 20.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 CCF34044.1 - 0.0044 16.2 0.0 0.0059 15.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 CCF34044.1 - 0.011 15.7 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase G-alpha PF00503.15 CCF34044.1 - 0.012 14.3 0.0 0.014 14.1 0.0 1.3 1 1 0 1 1 1 0 G-protein alpha subunit ABC_tran PF00005.22 CCF34044.1 - 0.088 13.1 0.0 0.23 11.7 0.0 1.4 1 1 0 1 1 1 0 ABC transporter Arch_ATPase PF01637.13 CCF34044.1 - 0.12 12.1 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase CAF-1_p150 PF11600.3 CCF34045.1 - 0.65 9.3 7.0 0.76 9.1 4.9 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal ATP-synt_B PF00430.13 CCF34045.1 - 1.6 8.5 9.4 2 8.2 6.5 1.1 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Nop53 PF07767.6 CCF34045.1 - 2.2 7.1 7.9 2.7 6.9 5.5 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) BAH PF01426.13 CCF34046.1 - 0.0001 21.9 0.1 0.00027 20.6 0.0 1.8 1 1 1 2 2 2 1 BAH domain PHD PF00628.24 CCF34046.1 - 0.00027 20.5 1.7 0.00075 19.1 1.2 1.8 1 0 0 1 1 1 1 PHD-finger FANCL_C PF11793.3 CCF34046.1 - 0.01 15.7 1.2 0.023 14.6 0.9 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain Lipoprotein_20 PF13942.1 CCF34046.1 - 0.022 14.3 1.2 5.4 6.5 0.0 2.3 2 0 0 2 2 2 0 YfhG lipoprotein ATG22 PF11700.3 CCF34047.1 - 2.9e-199 662.4 13.8 3.4e-199 662.2 9.5 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like Tyrosinase PF00264.15 CCF34048.1 - 7.8e-44 150.4 1.4 9.8e-44 150.1 1.0 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase Surface_antigen PF11054.3 CCF34049.1 - 0.082 12.2 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Sporozoite TA4 surface antigen DUF3571 PF12095.3 CCF34049.1 - 0.12 12.5 0.1 10 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3571) Mannitol_dh PF01232.18 CCF34050.1 - 3.6e-16 59.4 0.0 3.9e-16 59.3 0.0 1.0 1 0 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain UDPG_MGDP_dh_N PF03721.9 CCF34050.1 - 0.00023 20.5 0.1 0.00028 20.3 0.0 1.1 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.13 CCF34050.1 - 0.0014 18.3 0.0 0.0016 18.1 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.11 CCF34050.1 - 0.049 13.0 0.0 0.064 12.6 0.0 1.2 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.18 CCF34050.1 - 0.052 13.2 0.1 0.23 11.1 0.1 1.8 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DUF2250 PF10007.4 CCF34051.1 - 0.15 11.9 1.9 0.17 11.8 0.9 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) OB_NTP_bind PF07717.11 CCF34052.1 - 2.2e-29 101.5 0.0 1.4e-28 99.0 0.0 2.2 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 CCF34052.1 - 2.8e-27 94.7 0.2 2.8e-27 94.7 0.2 2.1 2 0 0 2 2 2 1 Helicase associated domain (HA2) S1 PF00575.18 CCF34052.1 - 7.2e-12 45.2 0.9 1.4e-11 44.2 0.6 1.5 1 0 0 1 1 1 1 S1 RNA binding domain Helicase_C PF00271.26 CCF34052.1 - 3.9e-11 42.6 0.0 9.1e-11 41.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 CCF34052.1 - 5.4e-07 29.8 0.0 1.3e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain DEAD PF00270.24 CCF34052.1 - 1.9e-06 27.4 0.1 4.2e-06 26.3 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 CCF34052.1 - 0.00022 20.2 0.0 0.00051 19.0 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.1 CCF34052.1 - 0.0011 18.5 0.3 0.0052 16.3 0.1 2.0 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CCF34052.1 - 0.024 14.3 0.1 0.066 12.9 0.1 1.8 1 0 0 1 1 1 0 Part of AAA domain AAA_14 PF13173.1 CCF34052.1 - 0.046 13.6 0.1 0.29 11.0 0.1 2.1 1 1 0 1 1 1 0 AAA domain PhoH PF02562.11 CCF34052.1 - 0.058 12.6 0.0 0.14 11.3 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.22 CCF34052.1 - 0.075 13.3 0.1 1 9.6 0.1 2.6 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.1 CCF34052.1 - 0.13 11.8 0.0 0.32 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain IPK PF03770.11 CCF34053.1 - 1.9e-53 181.0 0.0 2.8e-53 180.5 0.0 1.3 1 0 0 1 1 1 1 Inositol polyphosphate kinase Nucleos_tra2_C PF07662.8 CCF34054.1 - 4.3e-72 241.9 2.8 4.3e-72 241.9 1.9 2.5 2 1 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.15 CCF34054.1 - 2.5e-22 78.9 0.9 2.5e-22 78.9 0.6 2.8 4 0 0 4 4 4 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.9 CCF34054.1 - 6 6.8 25.7 0.27 11.1 5.4 4.0 4 0 0 4 4 4 0 Nucleoside recognition Beta_helix PF13229.1 CCF34055.1 - 4.2e-06 26.6 2.4 4.2e-06 26.6 1.7 1.5 2 0 0 2 2 2 1 Right handed beta helix region Chondroitinas_B PF14592.1 CCF34055.1 - 1.8e-05 23.7 0.1 3.2e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Chondroitinase B DUF1565 PF07602.6 CCF34055.1 - 0.00042 19.5 0.1 0.0011 18.1 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1565) Fungal_trans PF04082.13 CCF34057.1 - 3.2e-14 52.4 0.0 7.4e-14 51.2 0.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF34057.1 - 0.00033 20.4 6.7 0.00059 19.6 4.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Spt20 PF12090.3 CCF34059.1 - 3.8e-48 163.2 0.0 3.8e-48 163.2 0.0 4.6 4 2 0 4 4 4 1 Spt20 family ATG27 PF09451.5 CCF34060.1 - 6.7e-75 251.7 0.0 8.5e-75 251.4 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 Asp-B-Hydro_N PF05279.6 CCF34060.1 - 2.2 8.0 6.8 0.19 11.5 1.2 1.7 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region TPR_12 PF13424.1 CCF34061.1 - 0.043 13.7 2.9 5.4 7.0 0.0 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 CCF34061.1 - 0.14 12.0 0.6 41 4.3 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat EthD PF07110.6 CCF34062.1 - 8.2e-16 58.7 0.0 9.7e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 EthD domain OmdA PF13376.1 CCF34062.1 - 0.06 12.9 0.1 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated Ceramidase PF05875.7 CCF34063.1 - 1.2e-49 168.8 2.4 1.5e-49 168.5 1.6 1.0 1 0 0 1 1 1 1 Ceramidase Leader_Trp PF08255.6 CCF34063.1 - 0.087 12.5 3.2 0.43 10.3 2.2 2.2 1 0 0 1 1 1 0 Trp-operon Leader Peptide SID-1_RNA_chan PF13965.1 CCF34063.1 - 0.42 8.7 7.1 0.023 12.8 0.9 1.8 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Glyco_tranf_2_3 PF13641.1 CCF34064.1 - 4.4e-19 69.2 0.2 6.3e-19 68.6 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 CCF34064.1 - 1.7e-08 33.9 0.2 6.1e-08 32.1 0.1 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 CCF34064.1 - 3.9e-07 29.9 0.0 7.3e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 CcmD PF04995.9 CCF34065.1 - 0.00028 20.5 1.9 0.00064 19.3 1.3 1.6 1 0 0 1 1 1 1 Heme exporter protein D (CcmD) DUF456 PF04306.8 CCF34065.1 - 0.062 13.3 0.2 0.14 12.2 0.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF456) 7TM_GPCR_Srz PF10325.4 CCF34065.1 - 0.094 11.8 0.3 0.12 11.4 0.2 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srz DUF3433 PF11915.3 CCF34066.1 - 7e-20 70.9 3.5 7e-20 70.9 2.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3433) FA_desaturase PF00487.19 CCF34067.1 - 0.12 11.7 1.5 0.11 11.9 0.4 1.4 1 1 0 1 1 1 0 Fatty acid desaturase Aminotran_1_2 PF00155.16 CCF34068.1 - 3.4e-06 26.2 0.0 4e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DUF3435 PF11917.3 CCF34072.1 - 3.4e-64 217.1 1.4 5.1e-64 216.5 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3435) TRAUB PF08164.7 CCF34073.1 - 2.8e-21 75.4 1.5 3.1e-21 75.2 1.0 1.1 1 0 0 1 1 1 1 Apoptosis-antagonizing transcription factor, C-terminal Prothymosin PF03247.9 CCF34073.1 - 0.029 14.5 3.5 0.035 14.2 2.5 1.1 1 0 0 1 1 1 0 Prothymosin/parathymosin family Remorin_C PF03763.8 CCF34073.1 - 0.7 9.4 4.5 0.78 9.2 3.1 1.0 1 0 0 1 1 1 0 Remorin, C-terminal region BTV_NS2 PF04514.7 CCF34073.1 - 0.94 8.2 4.3 1 8.1 3.0 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Chal_sti_synt_N PF00195.14 CCF34076.1 - 1.3e-24 86.6 0.1 2.2e-24 85.9 0.1 1.2 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain Chal_sti_synt_C PF02797.10 CCF34076.1 - 7.3e-20 71.4 0.0 1.9e-19 70.0 0.0 1.6 2 0 0 2 2 2 1 Chalcone and stilbene synthases, C-terminal domain FAE1_CUT1_RppA PF08392.7 CCF34076.1 - 4.5e-06 25.9 0.4 7e-06 25.3 0.0 1.4 2 0 0 2 2 2 1 FAE1/Type III polyketide synthase-like protein ACP_syn_III_C PF08541.5 CCF34076.1 - 0.00047 20.1 0.0 0.0016 18.4 0.0 2.0 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.5 CCF34076.1 - 0.0029 17.2 0.5 0.0089 15.6 0.1 2.0 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Glyco_hydro_16 PF00722.16 CCF34077.1 - 7.6e-11 41.6 0.0 2e-10 40.2 0.0 1.7 2 1 0 2 2 2 1 Glycosyl hydrolases family 16 SKN1 PF03935.10 CCF34077.1 - 0.0064 14.7 0.0 0.012 13.8 0.0 1.3 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Pex14_N PF04695.8 CCF34077.1 - 0.96 9.4 7.3 1.9 8.5 5.0 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region bPH_2 PF03703.9 CCF34078.1 - 0.094 12.7 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial PH domain E1-E2_ATPase PF00122.15 CCF34080.1 - 3.2e-58 196.4 2.4 3.2e-58 196.4 1.7 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CCF34080.1 - 2.9e-44 150.7 6.2 2.9e-44 150.7 4.3 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CCF34080.1 - 1.1e-30 107.6 0.6 2.3e-30 106.6 0.4 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF34080.1 - 9.2e-19 67.2 0.0 1.9e-18 66.1 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 CCF34080.1 - 1.8e-13 51.1 0.0 4.2e-13 49.8 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 CCF34080.1 - 1.9e-12 46.4 0.0 6.3e-10 38.3 0.0 2.7 2 0 0 2 2 2 2 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 CCF34080.1 - 7.1e-05 22.5 0.2 0.00039 20.0 0.1 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Kelch_4 PF13418.1 CCF34083.1 - 6e-46 153.9 17.0 2.9e-11 42.9 0.1 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.1 CCF34083.1 - 3.7e-41 138.4 15.0 7.6e-07 28.9 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.20 CCF34083.1 - 7.8e-40 134.1 14.7 1.2e-08 34.3 0.4 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.1 CCF34083.1 - 1.3e-39 133.4 35.9 1.3e-10 41.1 0.1 7.6 8 0 0 8 8 8 6 Galactose oxidase, central domain Kelch_6 PF13964.1 CCF34083.1 - 2.2e-35 119.3 14.2 9.9e-07 28.6 0.0 6.3 5 1 1 6 6 6 6 Kelch motif Kelch_2 PF07646.10 CCF34083.1 - 8.6e-33 110.8 16.0 3.7e-08 32.8 0.2 6.6 6 0 0 6 6 6 6 Kelch motif TPPII_N PF12583.3 CCF34083.1 - 0.27 11.3 2.1 0.5 10.5 1.4 1.3 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal DUF1547 PF07577.6 CCF34084.1 - 0.42 10.3 1.8 0.77 9.4 1.2 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1547) HSF_DNA-bind PF00447.12 CCF34085.1 - 5.5e-31 106.8 1.7 1.2e-30 105.6 1.2 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.19 CCF34085.1 - 1.4e-19 70.1 0.0 2.4e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain DUF16 PF01519.11 CCF34085.1 - 0.091 12.9 6.2 0.19 11.9 4.3 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 DUF972 PF06156.8 CCF34085.1 - 0.13 12.6 3.6 0.3 11.4 2.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF972) bZIP_1 PF00170.16 CCF34085.1 - 0.25 11.3 2.0 0.27 11.2 0.4 1.8 2 0 0 2 2 2 0 bZIP transcription factor DivIC PF04977.10 CCF34085.1 - 0.32 10.5 3.3 0.64 9.5 2.3 1.5 1 0 0 1 1 1 0 Septum formation initiator IncA PF04156.9 CCF34085.1 - 3.5 7.1 7.8 5.7 6.4 5.4 1.2 1 0 0 1 1 1 0 IncA protein DIOX_N PF14226.1 CCF34086.1 - 2.1e-21 76.6 0.0 1.2e-20 74.1 0.0 2.1 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 CCF34086.1 - 2.4e-12 47.0 0.0 3.9e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.11 CCF34087.1 - 5.5e-23 81.2 27.3 5.5e-23 81.2 19.0 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily AA_permease_2 PF13520.1 CCF34088.1 - 1.4e-36 126.0 54.7 1.7e-36 125.6 37.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF34088.1 - 6.9e-16 57.6 43.9 1.3e-15 56.7 30.5 1.3 1 1 0 1 1 1 1 Amino acid permease VIT1 PF01988.14 CCF34088.1 - 0.024 14.1 0.2 0.024 14.1 0.1 3.3 4 1 0 4 4 4 0 VIT family SNF2_N PF00176.18 CCF34089.1 - 8e-83 277.6 1.8 8e-83 277.6 1.2 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.20 CCF34089.1 - 1.7e-20 72.6 0.2 5.9e-20 70.9 0.1 1.9 1 0 0 1 1 1 1 Bromodomain Helicase_C PF00271.26 CCF34089.1 - 3.1e-18 65.3 0.1 6.8e-17 61.1 0.0 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SnAC PF14619.1 CCF34089.1 - 1.7e-16 60.1 1.0 1.7e-16 60.1 0.7 3.0 2 0 0 2 2 2 1 Snf2-ATP coupling, chromatin remodelling complex HSA PF07529.8 CCF34089.1 - 1.2e-11 44.2 12.4 1.2e-11 44.2 8.6 3.9 4 0 0 4 4 4 1 HSA QLQ PF08880.6 CCF34089.1 - 1.4e-10 40.4 4.7 4.9e-10 38.6 3.2 2.1 1 0 0 1 1 1 1 QLQ Zn_clus PF00172.13 CCF34090.1 - 6.8e-11 41.9 7.6 1.1e-10 41.2 5.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldedh PF00171.17 CCF34093.1 - 1e-74 251.6 0.1 1.1e-74 251.4 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Whi5 PF08528.6 CCF34094.1 - 1.8e-06 27.3 0.1 3.4e-06 26.5 0.1 1.5 1 0 0 1 1 1 1 Whi5 like MSP1_C PF07462.6 CCF34094.1 - 5.9 5.1 6.9 8.7 4.6 4.8 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus RTA1 PF04479.8 CCF34095.1 - 1.4e-33 116.2 7.9 1.8e-33 115.9 5.5 1.1 1 0 0 1 1 1 1 RTA1 like protein zf-DHHC PF01529.15 CCF34095.1 - 3.4 7.0 9.3 23 4.3 4.7 2.8 1 1 1 2 2 2 0 DHHC palmitoyltransferase MFS_1 PF07690.11 CCF34096.1 - 6.8e-30 103.9 22.7 5.7e-23 81.1 5.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4131 PF13567.1 CCF34096.1 - 0.13 11.6 4.4 1.9 7.8 0.5 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) DIOX_N PF14226.1 CCF34097.1 - 4.9e-13 49.6 0.0 1.4e-12 48.1 0.0 1.7 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 CCF34097.1 - 7.6e-11 42.1 0.0 1.3e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily NAD_binding_2 PF03446.10 CCF34098.1 - 6.1e-25 87.9 0.4 1e-24 87.2 0.3 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 CCF34098.1 - 5.7e-09 36.0 0.0 1.4e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.12 CCF34098.1 - 1e-05 25.8 0.1 5.7e-05 23.4 0.0 2.2 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 CCF34098.1 - 0.0019 18.3 0.0 0.0033 17.5 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 CCF34098.1 - 0.016 14.3 0.0 0.029 13.5 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PDH PF02153.12 CCF34098.1 - 0.061 12.1 0.1 0.1 11.4 0.0 1.3 1 0 0 1 1 1 0 Prephenate dehydrogenase GST_C PF00043.20 CCF34099.1 - 3.7e-11 42.8 0.0 5.9e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 CCF34099.1 - 3.6e-09 36.3 0.2 9.3e-09 35.0 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 CCF34099.1 - 1.6e-07 31.4 0.0 3.1e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 CCF34099.1 - 1.5e-06 28.2 0.1 5.2e-06 26.5 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 CCF34099.1 - 1e-05 25.9 0.0 1.6e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain 2OG-FeII_Oxy PF03171.15 CCF34100.1 - 1e-08 35.3 0.1 1.6e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TRH PF05438.7 CCF34100.1 - 0.049 13.0 0.1 0.069 12.5 0.0 1.2 1 0 0 1 1 1 0 Thyrotropin-releasing hormone (TRH) DUF3455 PF11937.3 CCF34101.1 - 5.9e-28 98.0 0.1 7.1e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) Peptidase_M43 PF05572.8 CCF34102.1 - 7.3e-10 38.6 0.0 9.8e-10 38.2 0.0 1.3 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_2 PF13574.1 CCF34102.1 - 0.00014 21.9 0.1 0.00024 21.1 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 CCF34102.1 - 0.00057 19.8 1.1 0.00082 19.3 0.7 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.1 CCF34102.1 - 0.0016 17.9 0.0 0.0026 17.3 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.19 CCF34102.1 - 0.0096 15.6 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.1 CCF34102.1 - 0.025 15.1 0.7 0.046 14.2 0.5 1.7 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.3 CCF34102.1 - 0.078 11.4 0.1 0.1 11.0 0.1 1.1 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M66 PF10462.4 CCF34102.1 - 0.11 11.3 0.1 0.15 10.8 0.1 1.2 1 0 0 1 1 1 0 Peptidase M66 Oxidored_FMN PF00724.15 CCF34104.1 - 3.1e-79 266.4 0.0 4.4e-79 265.9 0.0 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family adh_short PF00106.20 CCF34105.1 - 8.1e-23 81.1 0.8 1.1e-22 80.7 0.5 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF34105.1 - 1.1e-08 35.2 0.0 1.5e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF34105.1 - 2.4e-08 33.8 0.4 4.3e-08 33.0 0.2 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF34105.1 - 4.4e-06 26.8 1.2 1.1e-05 25.5 0.8 1.8 1 1 0 1 1 1 1 NADH(P)-binding 3HCDH_N PF02737.13 CCF34105.1 - 0.0028 17.3 0.1 0.0048 16.5 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.16 CCF34105.1 - 0.0047 16.3 0.1 0.04 13.3 0.1 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.21 CCF34105.1 - 0.029 13.9 0.4 0.063 12.8 0.1 1.6 2 0 0 2 2 2 0 Zinc-binding dehydrogenase Eno-Rase_NADH_b PF12242.3 CCF34105.1 - 0.12 12.2 0.1 0.33 10.7 0.0 1.7 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase YjeF_N PF03853.10 CCF34105.1 - 0.13 11.8 0.7 0.49 9.9 0.2 2.1 2 1 0 2 2 2 0 YjeF-related protein N-terminus EamA PF00892.15 CCF34106.1 - 5.1e-10 39.4 27.9 1.5e-05 25.0 0.9 2.9 3 0 0 3 3 3 2 EamA-like transporter family EmrE PF13536.1 CCF34106.1 - 7.9e-07 29.2 0.7 7.9e-07 29.2 0.5 2.8 3 1 0 3 3 3 1 Multidrug resistance efflux transporter Nuc_sug_transp PF04142.10 CCF34106.1 - 0.0052 15.9 3.4 0.0075 15.3 0.0 2.1 2 0 0 2 2 2 1 Nucleotide-sugar transporter TPT PF03151.11 CCF34106.1 - 0.25 10.9 22.7 0.24 11.0 7.3 3.1 2 1 0 2 2 2 0 Triose-phosphate Transporter family DUF202 PF02656.10 CCF34106.1 - 3.8 7.8 11.5 1.4 9.1 1.4 3.8 3 1 0 3 3 3 0 Domain of unknown function (DUF202) Aldo_ket_red PF00248.16 CCF34107.1 - 1.6e-53 181.3 0.0 1.8e-53 181.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Glyco_hydro_16 PF00722.16 CCF34109.1 - 3.4e-16 59.0 0.0 1.5e-15 57.0 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.10 CCF34109.1 - 1.5e-06 26.6 0.7 0.0019 16.4 0.0 2.1 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) zf-C2H2_2 PF12756.2 CCF34110.1 - 1.6e-35 121.2 12.8 6.1e-30 103.3 2.8 3.5 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 CCF34110.1 - 2.2e-07 30.8 3.8 2.2e-07 30.8 2.6 4.7 5 0 0 5 5 5 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CCF34110.1 - 4.9e-07 29.7 2.8 4.9e-07 29.7 1.9 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 CCF34110.1 - 2.6e-05 23.9 3.3 0.0081 16.0 0.9 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger Homeobox_KN PF05920.6 CCF34110.1 - 0.096 12.4 0.0 0.39 10.4 0.0 2.1 2 0 0 2 2 2 0 Homeobox KN domain SnoaL_2 PF12680.2 CCF34110.1 - 0.1 13.0 3.1 0.55 10.6 1.3 2.5 2 0 0 2 2 2 0 SnoaL-like domain zf-C2H2 PF00096.21 CCF34110.1 - 1.4 9.4 20.2 2.6 8.5 0.5 4.7 4 0 0 4 4 4 0 Zinc finger, C2H2 type DUF4606 PF15379.1 CCF34110.1 - 6.3 6.9 7.3 4.1 7.5 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4606) zf-C2H2_4 PF13894.1 CCF34110.1 - 6.9 7.2 15.6 1.1 9.7 0.5 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger MMR_HSR1 PF01926.18 CCF34111.1 - 4e-19 68.6 0.0 6e-19 68.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 CCF34111.1 - 1.3e-07 31.5 0.4 0.0027 17.5 0.4 2.2 2 0 0 2 2 2 2 Dynamin family IIGP PF05049.8 CCF34111.1 - 8e-07 28.1 0.0 0.012 14.4 0.0 2.1 2 0 0 2 2 2 2 Interferon-inducible GTPase (IIGP) FeoB_N PF02421.13 CCF34111.1 - 5.8e-06 25.6 0.1 0.00029 20.1 0.1 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 CCF34111.1 - 0.00013 21.5 0.0 0.0011 18.3 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Miro PF08477.8 CCF34111.1 - 0.0026 18.2 0.1 0.091 13.2 0.1 2.3 2 0 0 2 2 2 1 Miro-like protein DUF258 PF03193.11 CCF34111.1 - 0.02 14.1 0.2 0.13 11.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 CCF34111.1 - 0.056 12.9 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Septin PF00735.13 CCF34111.1 - 0.063 12.2 0.0 0.29 10.0 0.0 1.9 1 1 0 1 1 1 0 Septin PduV-EutP PF10662.4 CCF34111.1 - 0.079 12.4 0.0 6.7 6.1 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AIG1 PF04548.11 CCF34111.1 - 0.087 11.9 0.1 7.6 5.5 0.0 2.1 2 0 0 2 2 2 0 AIG1 family GBP PF02263.14 CCF34111.1 - 0.14 11.1 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain AAA_16 PF13191.1 CCF34111.1 - 0.16 11.9 0.0 0.58 10.1 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain zf-C3HC PF07967.8 CCF34112.1 - 3.3e-39 133.7 2.9 5.4e-35 120.0 0.2 3.0 3 0 0 3 3 3 2 C3HC zinc finger-like Rsm1 PF08600.5 CCF34112.1 - 2.8e-27 94.3 2.1 6.1e-26 90.0 0.1 2.5 2 0 0 2 2 2 1 Rsm1-like BIR PF00653.16 CCF34112.1 - 1.8e-05 25.0 0.1 0.00052 20.3 0.0 2.5 2 0 0 2 2 2 1 Inhibitor of Apoptosis domain Dicty_REP PF05086.7 CCF34112.1 - 0.94 7.1 4.6 1.1 6.8 3.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Rhabdo_M1 PF03342.8 CCF34113.1 - 0.00093 18.3 0.1 0.0011 18.1 0.1 1.0 1 0 0 1 1 1 1 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein) Birna_VP3 PF01767.11 CCF34113.1 - 0.012 15.1 0.4 0.016 14.8 0.3 1.2 1 0 0 1 1 1 0 Birnavirus VP3 protein ASXH PF13919.1 CCF34113.1 - 0.07 12.9 2.4 0.15 11.8 1.5 1.6 1 1 1 2 2 2 0 Asx homology domain FAM176 PF14851.1 CCF34113.1 - 0.079 12.6 0.6 0.097 12.3 0.4 1.1 1 0 0 1 1 1 0 FAM176 family SRP-alpha_N PF04086.8 CCF34113.1 - 0.17 11.2 3.6 0.2 10.9 2.5 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Calpain_inhib PF00748.14 CCF34113.1 - 0.3 11.4 4.6 0.29 11.4 2.6 1.3 1 1 0 1 1 1 0 Calpain inhibitor Stm1_N PF09598.5 CCF34113.1 - 1.7 9.3 11.4 1.2 9.8 6.8 1.7 1 1 1 2 2 2 0 Stm1 AMP-binding PF00501.23 CCF34116.1 - 2.5e-77 260.0 0.2 5.1e-77 259.0 0.0 1.5 2 0 0 2 2 2 1 AMP-binding enzyme Condensation PF00668.15 CCF34116.1 - 9.4e-49 165.8 0.0 1.4e-48 165.2 0.0 1.2 1 0 0 1 1 1 1 Condensation domain NAD_binding_4 PF07993.7 CCF34116.1 - 5.3e-23 81.2 0.0 3.4e-22 78.5 0.0 2.3 2 1 0 2 2 2 1 Male sterility protein PP-binding PF00550.20 CCF34116.1 - 9.9e-16 57.7 0.0 1.8e-09 37.6 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site HxxPF_rpt PF13745.1 CCF34116.1 - 1.6e-07 31.5 0.0 5.7e-07 29.7 0.0 1.9 2 0 0 2 2 2 1 HxxPF-repeated domain AMP-binding_C PF13193.1 CCF34116.1 - 2.8e-06 28.1 0.1 0.00016 22.5 0.0 2.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain RmlD_sub_bind PF04321.12 CCF34116.1 - 0.0062 15.4 1.0 0.035 12.9 0.0 2.5 3 0 0 3 3 3 1 RmlD substrate binding domain COesterase PF00135.23 CCF34116.1 - 0.064 11.9 0.0 0.1 11.2 0.0 1.2 1 0 0 1 1 1 0 Carboxylesterase family DAO PF01266.19 CCF34117.1 - 2.3e-43 148.4 0.0 5.2e-43 147.3 0.0 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 CCF34117.1 - 8.9e-07 29.1 0.1 0.00017 21.7 0.1 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF34117.1 - 1.8e-05 24.5 0.1 0.0075 16.0 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 CCF34117.1 - 0.0001 22.2 0.0 0.42 10.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF34117.1 - 0.00056 19.8 0.0 0.0018 18.2 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.9 CCF34117.1 - 0.0068 15.0 0.0 0.89 8.0 0.0 2.3 2 0 0 2 2 2 2 Tryptophan halogenase Lycopene_cycl PF05834.7 CCF34117.1 - 0.019 13.8 0.0 0.088 11.7 0.0 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein GIDA PF01134.17 CCF34117.1 - 0.037 12.8 0.0 0.13 11.1 0.0 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_binding_7 PF13241.1 CCF34117.1 - 0.075 13.2 0.0 0.14 12.4 0.0 1.5 1 1 0 1 1 1 0 Putative NAD(P)-binding Zn_clus PF00172.13 CCF34118.1 - 4e-09 36.2 9.4 9.3e-09 35.0 6.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF34118.1 - 4.6e-09 35.5 0.1 8.8e-09 34.6 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain COG5 PF10392.4 CCF34119.1 - 0.0078 16.1 0.4 0.0088 15.9 0.3 1.0 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Syntaxin-6_N PF09177.6 CCF34119.1 - 0.044 14.1 0.4 0.044 14.1 0.3 1.1 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Zn_clus PF00172.13 CCF34120.1 - 4.6e-08 32.8 12.3 9e-08 31.9 8.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glucosamine_iso PF01182.15 CCF34121.1 - 9.8e-24 84.1 0.0 1.1e-23 83.9 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase DUF2142 PF09913.4 CCF34121.1 - 0.14 10.7 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) SET PF00856.23 CCF34122.1 - 0.0026 18.0 0.2 0.09 13.0 0.1 2.6 2 1 0 2 2 2 1 SET domain TPR_11 PF13414.1 CCF34122.1 - 0.013 15.1 1.9 0.55 9.9 0.0 2.5 2 0 0 2 2 2 0 TPR repeat zf-MYND PF01753.13 CCF34122.1 - 1.2 9.1 13.9 0.03 14.2 4.5 2.2 2 0 0 2 2 2 0 MYND finger DUF1771 PF08590.5 CCF34123.1 - 5.2e-25 87.2 10.3 5.2e-25 87.2 7.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.16 CCF34123.1 - 4.3e-13 49.2 0.2 1.2e-12 47.7 0.2 1.8 1 0 0 1 1 1 1 Smr domain OmpH PF03938.9 CCF34123.1 - 1 9.3 5.3 0.18 11.7 0.9 1.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) zf-Tim10_DDP PF02953.10 CCF34124.1 - 2.9e-19 68.1 4.6 4.6e-19 67.4 3.2 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Folate_rec PF03024.9 CCF34124.1 - 0.029 13.9 2.6 0.032 13.8 1.8 1.0 1 0 0 1 1 1 0 Folate receptor family UPF0137 PF03677.8 CCF34124.1 - 0.14 11.7 2.4 0.27 10.7 1.6 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0137) ABC_tran PF00005.22 CCF34126.1 - 9.6e-40 136.0 0.0 7.4e-22 78.1 0.0 2.7 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.18 CCF34126.1 - 9.2e-30 103.9 25.9 1.3e-18 67.4 8.3 2.7 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.14 CCF34126.1 - 3e-10 39.7 0.0 0.026 13.7 0.0 4.9 4 1 1 5 5 5 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF34126.1 - 1.3e-06 28.6 0.0 0.46 10.3 0.0 4.4 3 1 0 4 4 4 1 AAA domain AAA_29 PF13555.1 CCF34126.1 - 9.3e-06 25.0 0.5 0.059 12.9 0.0 2.9 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 CCF34126.1 - 1.7e-05 24.9 0.1 0.04 13.9 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 CCF34126.1 - 0.00011 22.3 0.0 0.28 11.3 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_17 PF13207.1 CCF34126.1 - 0.00011 22.9 0.0 0.22 12.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 CCF34126.1 - 0.00014 21.2 0.2 0.21 10.9 0.1 2.8 2 1 0 2 2 2 2 AAA domain AAA_33 PF13671.1 CCF34126.1 - 0.0002 21.2 0.0 0.034 14.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain Adeno_IVa2 PF02456.10 CCF34126.1 - 0.001 17.8 0.1 0.11 11.1 0.0 2.7 3 0 0 3 3 3 1 Adenovirus IVa2 protein Dynamin_N PF00350.18 CCF34126.1 - 0.0017 18.1 0.1 0.13 12.0 0.0 2.3 2 0 0 2 2 2 1 Dynamin family AAA_23 PF13476.1 CCF34126.1 - 0.0022 18.3 0.1 0.76 10.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 CCF34126.1 - 0.0027 18.2 0.0 1 9.8 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein DUF258 PF03193.11 CCF34126.1 - 0.0031 16.6 0.1 0.24 10.5 0.0 2.6 3 0 0 3 3 3 1 Protein of unknown function, DUF258 ATP_bind_1 PF03029.12 CCF34126.1 - 0.0037 16.8 0.0 0.057 12.9 0.0 2.3 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.1 CCF34126.1 - 0.0052 17.0 0.0 2.3 8.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 CCF34126.1 - 0.0054 16.6 0.1 4.2 7.3 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_10 PF12846.2 CCF34126.1 - 0.007 15.8 0.1 1.5 8.1 0.0 2.3 2 0 0 2 2 2 1 AAA-like domain MobB PF03205.9 CCF34126.1 - 0.014 15.0 0.3 2.4 7.8 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B SbcCD_C PF13558.1 CCF34126.1 - 0.053 13.4 0.2 3 7.8 0.0 3.2 3 0 0 3 3 3 0 Putative exonuclease SbcCD, C subunit DUF87 PF01935.12 CCF34126.1 - 0.078 12.7 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF87 T2SE PF00437.15 CCF34126.1 - 0.089 11.6 0.4 3.5 6.4 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA PF00004.24 CCF34126.1 - 0.14 12.3 0.1 3.7 7.7 0.0 2.8 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.4 CCF34126.1 - 0.17 11.4 0.9 2.4 7.6 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FtsK_SpoIIIE PF01580.13 CCF34126.1 - 0.22 10.9 0.2 6.2 6.2 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF3328 PF11807.3 CCF34127.1 - 1.5e-50 171.9 0.0 1.8e-50 171.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.3 CCF34128.1 - 8.8e-50 169.3 0.0 1.1e-49 169.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) MFS_1 PF07690.11 CCF34130.1 - 1.7e-12 46.7 35.5 1.7e-12 46.7 24.6 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.15 CCF34130.1 - 0.061 11.3 8.4 0.066 11.2 3.2 2.4 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family GET2 PF08690.5 CCF34130.1 - 0.17 11.1 0.6 0.29 10.3 0.4 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 PTR2 PF00854.16 CCF34131.1 - 2.4e-14 52.9 3.0 2.4e-14 52.9 2.1 1.4 2 0 0 2 2 2 1 POT family Maff2 PF12750.2 CCF34131.1 - 0.32 10.5 0.0 0.32 10.5 0.0 2.6 3 0 0 3 3 3 0 Maff2 family SnoaL PF07366.7 CCF34132.1 - 3.2e-07 29.9 0.0 7.5e-07 28.7 0.0 1.6 2 0 0 2 2 2 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.2 CCF34132.1 - 2.6e-05 24.5 0.0 0.00012 22.4 0.0 2.0 2 0 0 2 2 2 1 SnoaL-like domain EBP PF05241.7 CCF34133.1 - 0.0024 16.8 0.2 0.0024 16.8 0.2 1.6 1 1 1 2 2 2 1 Emopamil binding protein Glyco_hydro_16 PF00722.16 CCF34135.1 - 8.1e-19 67.6 1.5 1.4e-18 66.8 1.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 TaqI_C PF12950.2 CCF34135.1 - 0.033 13.9 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 TaqI-like C-terminal specificity domain zf-C3HC4_2 PF13923.1 CCF34136.1 - 6.3e-09 35.7 8.8 6.3e-09 35.7 6.1 3.4 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF34136.1 - 1.1e-07 31.4 4.0 1.1e-07 31.4 2.7 3.2 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF34136.1 - 1.7e-07 30.9 7.7 1.7e-07 30.9 5.4 3.4 2 1 1 3 3 3 1 Ring finger domain zf-RING_5 PF14634.1 CCF34136.1 - 1.7e-06 27.6 6.2 1.7e-06 27.6 4.3 3.5 2 2 0 2 2 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 CCF34136.1 - 1.9e-06 27.4 8.7 1.9e-06 27.4 6.1 3.3 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 CCF34136.1 - 0.00016 21.3 7.0 0.00055 19.5 4.8 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.2 CCF34136.1 - 0.001 19.1 3.3 0.001 19.1 2.3 3.4 2 2 1 3 3 3 1 RING-H2 zinc finger Sina PF03145.11 CCF34136.1 - 0.0015 18.2 0.8 0.0015 18.2 0.6 2.5 3 0 0 3 3 3 1 Seven in absentia protein family zf-C3HC4_4 PF15227.1 CCF34136.1 - 0.0022 17.8 8.7 0.0022 17.8 6.1 2.5 3 1 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-TRAF PF02176.13 CCF34136.1 - 0.011 16.1 29.7 0.012 15.9 4.6 3.3 2 2 2 4 4 3 0 TRAF-type zinc finger U-box PF04564.10 CCF34136.1 - 0.02 14.8 0.4 0.063 13.2 0.2 2.0 2 0 0 2 2 2 0 U-box domain zf-P11 PF03854.9 CCF34136.1 - 0.029 13.8 1.9 0.029 13.8 1.3 3.2 2 2 1 3 3 3 0 P-11 zinc finger Toxin_3 PF00537.13 CCF34136.1 - 4.8 7.1 11.6 0.47 10.3 3.6 2.4 2 0 0 2 2 2 0 Scorpion toxin-like domain Peptidase_C2 PF00648.16 CCF34137.1 - 4.2e-58 196.7 6.4 1e-38 133.0 1.0 2.2 1 1 1 2 2 2 2 Calpain family cysteine protease A_deaminase PF00962.17 CCF34138.1 - 1.5e-23 83.2 0.0 1.6e-23 83.1 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_4 PF13147.1 CCF34138.1 - 0.028 14.4 0.0 0.036 14.0 0.0 1.2 1 0 0 1 1 1 0 Amidohydrolase Tautomerase PF01361.16 CCF34138.1 - 0.039 13.5 0.0 0.068 12.7 0.0 1.4 1 0 0 1 1 1 0 Tautomerase enzyme UDP-g_GGTase PF06427.6 CCF34139.1 - 4.4e-60 202.5 0.0 7.2e-60 201.8 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.15 CCF34139.1 - 1.2e-05 24.7 0.6 2.3e-05 23.8 0.4 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 SNF2_N PF00176.18 CCF34140.1 - 1.2e-68 231.0 0.0 1.8e-68 230.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.5 CCF34140.1 - 1.5e-60 204.3 5.1 3.2e-60 203.2 3.1 1.9 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.26 CCF34140.1 - 1.5e-12 47.1 0.0 5.3e-12 45.4 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 CCF34140.1 - 1.6e-05 23.8 0.0 6.1e-05 21.9 0.0 1.9 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.10 CCF34140.1 - 0.00046 20.0 0.0 0.0011 18.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 CCF34140.1 - 0.12 12.5 0.1 1.2 9.2 0.0 2.7 2 1 0 2 2 2 0 AAA domain HET PF06985.6 CCF34141.1 - 8e-29 100.5 0.0 1.2e-28 100.0 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Pribosyl_synth PF14572.1 CCF34142.1 - 4e-25 88.6 0.0 4.4e-25 88.5 0.0 1.0 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Ribosomal_S6e PF01092.14 CCF34143.1 - 4e-63 210.7 0.3 8.7e-63 209.6 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S6e Ctf8 PF09696.5 CCF34144.1 - 2.6e-32 111.1 0.0 3.1e-32 110.9 0.0 1.1 1 0 0 1 1 1 1 Ctf8 Glyco_hydro_10 PF00331.15 CCF34145.1 - 3.6e-85 285.8 0.0 4.1e-85 285.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Pkr1 PF08636.5 CCF34147.1 - 2.4e-31 107.6 9.3 3.2e-31 107.1 6.5 1.1 1 0 0 1 1 1 1 ER protein Pkr1 OAD_gamma PF04277.8 CCF34147.1 - 0.029 14.7 4.0 1.1 9.6 0.0 2.4 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF2763 PF10961.3 CCF34147.1 - 0.25 11.7 6.1 0.1 12.9 1.5 2.1 1 1 2 3 3 3 0 Protein of unknown function (DUF2763) Chorion_3 PF05387.6 CCF34147.1 - 0.8 9.0 10.7 1.1 8.5 7.4 1.3 1 0 0 1 1 1 0 Chorion family 3 MFS_2 PF13347.1 CCF34148.1 - 4e-11 41.9 15.2 4e-11 41.9 10.6 2.8 3 0 0 3 3 3 1 MFS/sugar transport protein MFS_1_like PF12832.2 CCF34148.1 - 0.01 15.5 2.6 0.25 11.1 0.0 3.7 3 0 0 3 3 3 0 MFS_1 like family PAP2 PF01569.16 CCF34148.1 - 0.5 10.0 9.1 0.074 12.7 1.5 3.0 3 1 1 4 4 4 0 PAP2 superfamily zf-RING_UBOX PF13445.1 CCF34149.1 - 0.47 10.2 9.3 0.28 10.9 0.4 3.1 2 0 0 2 2 2 0 RING-type zinc-finger Sugar_tr PF00083.19 CCF34150.1 - 2.7e-26 92.1 6.4 3.2e-26 91.9 4.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Thia_YuaJ PF09515.5 CCF34150.1 - 0.06 13.1 3.9 0.081 12.6 2.7 1.1 1 0 0 1 1 1 0 Thiamine transporter protein (Thia_YuaJ) DUF3311 PF11755.3 CCF34150.1 - 0.1 12.1 2.8 0.99 8.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3311) Pex14_N PF04695.8 CCF34150.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EBP PF05241.7 CCF34150.1 - 0.18 10.7 6.0 0.22 10.5 4.1 1.1 1 0 0 1 1 1 0 Emopamil binding protein 7tm_1 PF00001.16 CCF34150.1 - 0.33 10.0 7.6 1.9 7.5 0.8 2.1 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) DUF3382 PF11862.3 CCF34150.1 - 1.8 8.5 5.4 0.84 9.5 0.3 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF3382) zf-nanos PF05741.8 CCF34151.1 - 0.31 11.0 2.7 0.88 9.5 1.1 1.9 1 1 1 2 2 2 0 Nanos RNA binding domain MFS_1 PF07690.11 CCF34152.1 - 1.7e-26 92.7 38.7 8e-24 84.0 13.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily 14-3-3 PF00244.15 CCF34153.1 - 4.1e-09 35.8 0.0 2.6e-08 33.2 0.0 1.9 2 0 0 2 2 2 1 14-3-3 protein TMEM173 PF15009.1 CCF34155.1 - 0.21 10.3 0.6 0.3 9.8 0.4 1.2 1 0 0 1 1 1 0 Transmembrane protein 173 60KD_IMP PF02096.15 CCF34155.1 - 0.49 10.0 2.2 0.73 9.4 1.6 1.3 1 1 0 1 1 1 0 60Kd inner membrane protein DUF2516 PF10724.4 CCF34155.1 - 0.86 9.6 6.5 3.9 7.5 2.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2516) AAA_16 PF13191.1 CCF34156.1 - 2.2e-08 34.2 0.0 3.9e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.17 CCF34156.1 - 8.2e-08 31.4 0.0 2.7e-07 29.7 0.0 1.8 1 1 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.1 CCF34156.1 - 1.7e-06 28.1 0.0 8e-06 26.0 0.0 2.1 2 1 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 CCF34156.1 - 1.6e-05 24.7 0.0 2.4e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase AAA_14 PF13173.1 CCF34156.1 - 0.0014 18.4 0.0 0.0036 17.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 CCF34156.1 - 0.011 15.9 0.0 0.046 13.9 0.0 2.0 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) RecA PF00154.16 CCF34156.1 - 0.068 12.2 0.0 0.89 8.5 0.0 2.0 2 0 0 2 2 2 0 recA bacterial DNA recombination protein AAA_24 PF13479.1 CCF34156.1 - 0.071 12.6 1.9 0.12 11.9 0.4 2.1 2 1 0 2 2 2 0 AAA domain AAA_17 PF13207.1 CCF34156.1 - 0.11 13.3 0.0 0.25 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain MFS_1 PF07690.11 CCF34157.1 - 4e-31 108.0 51.7 1.8e-18 66.3 19.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CCF34157.1 - 6.7e-12 44.5 7.9 6.7e-12 44.5 5.4 2.6 1 1 2 3 3 3 1 MFS/sugar transport protein Sugar_tr PF00083.19 CCF34157.1 - 1.8e-10 40.0 38.9 5.6e-10 38.3 10.8 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter DUF106 PF01956.11 CCF34157.1 - 0.06 12.8 1.9 0.07 12.6 0.3 1.8 2 0 0 2 2 2 0 Integral membrane protein DUF106 Fungal_trans PF04082.13 CCF34158.1 - 2.7e-20 72.3 0.4 4.3e-20 71.6 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF34158.1 - 1.1e-05 25.2 13.8 1.9e-05 24.4 9.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3328 PF11807.3 CCF34159.1 - 0.016 14.8 0.2 1.2 8.7 0.1 2.5 2 1 0 3 3 3 0 Domain of unknown function (DUF3328) Helicase_IV_N PF12462.3 CCF34159.1 - 0.084 12.5 0.0 1.9 8.0 0.0 2.1 2 0 0 2 2 2 0 DNA helicase IV / RNA helicase N terminal GMC_oxred_N PF00732.14 CCF34160.1 - 2.4e-11 43.3 0.0 2.5e-11 43.2 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.1 CCF34160.1 - 2.4e-06 27.4 0.2 3.3e-06 27.0 0.1 1.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF34160.1 - 5.7e-06 25.4 0.0 5.7e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CCF34160.1 - 2.1e-05 23.5 0.0 2.1e-05 23.5 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.7 CCF34160.1 - 2.4e-05 23.4 0.1 2.7e-05 23.2 0.1 1.0 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.9 CCF34160.1 - 0.00056 19.8 0.0 0.00056 19.8 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF34160.1 - 0.0017 17.5 0.1 0.0019 17.3 0.1 1.1 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.9 CCF34160.1 - 0.0019 16.7 0.0 0.0022 16.5 0.0 1.0 1 0 0 1 1 1 1 HI0933-like protein TrkA_N PF02254.13 CCF34160.1 - 0.0041 17.1 0.0 0.0047 16.9 0.0 1.1 1 0 0 1 1 1 1 TrkA-N domain K_oxygenase PF13434.1 CCF34160.1 - 0.011 14.6 0.0 0.013 14.4 0.0 1.0 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 CCF34160.1 - 0.012 15.4 0.1 0.014 15.1 0.1 1.1 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 CCF34160.1 - 0.014 15.4 0.2 0.015 15.3 0.1 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF34160.1 - 0.063 11.8 0.1 0.069 11.7 0.1 1.0 1 0 0 1 1 1 0 Tryptophan halogenase FAD_binding_3 PF01494.14 CCF34160.1 - 0.066 12.2 0.1 0.073 12.1 0.0 1.0 1 0 0 1 1 1 0 FAD binding domain Romo1 PF10247.4 CCF34161.1 - 4.3e-27 94.1 12.6 6.4e-27 93.5 8.7 1.3 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Gly-zipper_OmpA PF13436.1 CCF34161.1 - 0.12 12.0 3.8 0.095 12.3 2.0 1.4 1 1 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Tim17 PF02466.14 CCF34161.1 - 0.62 10.1 8.8 3.4 7.7 6.2 1.8 1 1 1 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family FHA PF00498.21 CCF34162.1 - 1.4e-17 63.5 0.1 3.8e-17 62.1 0.0 1.8 1 0 0 1 1 1 1 FHA domain Uds1 PF15456.1 CCF34162.1 - 0.001 19.0 5.8 0.068 13.1 0.3 2.7 2 0 0 2 2 2 2 Up-regulated During Septation Prp19 PF08606.6 CCF34162.1 - 0.081 12.6 2.4 0.18 11.5 1.7 1.5 1 0 0 1 1 1 0 Prp19/Pso4-like DUF4407 PF14362.1 CCF34162.1 - 0.24 10.3 9.2 0.16 10.9 1.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Mnd1 PF03962.10 CCF34162.1 - 0.24 11.0 11.1 1.5 8.4 0.6 2.3 2 0 0 2 2 2 0 Mnd1 family DUF972 PF06156.8 CCF34162.1 - 0.37 11.1 8.6 0.16 12.3 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF972) GAS PF13851.1 CCF34162.1 - 0.54 9.4 10.7 0.12 11.5 1.3 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4047 PF13256.1 CCF34162.1 - 0.8 9.6 3.9 0.26 11.2 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) DivIC PF04977.10 CCF34162.1 - 1.7 8.1 7.7 0.38 10.2 0.4 2.5 2 0 0 2 2 2 0 Septum formation initiator Vps51 PF08700.6 CCF34162.1 - 8.9 6.2 10.6 1.8 8.4 0.3 2.8 3 0 0 3 3 3 0 Vps51/Vps67 Pec_lyase_C PF00544.14 CCF34163.1 - 2.1e-27 95.9 4.7 3e-27 95.4 3.3 1.2 1 0 0 1 1 1 1 Pectate lyase Beta_helix PF13229.1 CCF34163.1 - 9.4e-07 28.7 21.4 0.0001 22.1 7.3 2.2 1 1 1 2 2 2 2 Right handed beta helix region MFS_1 PF07690.11 CCF34164.1 - 2.1e-21 76.0 74.1 4.1e-14 52.0 24.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Aminotran_3 PF00202.16 CCF34165.1 - 7.3e-92 307.8 0.5 8.6e-92 307.5 0.4 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 CCF34165.1 - 0.017 14.1 0.0 0.031 13.2 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II Fungal_trans PF04082.13 CCF34166.1 - 0.015 14.1 0.0 0.023 13.5 0.0 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain HTH_psq PF05225.11 CCF34167.1 - 9.7e-11 41.0 1.5 1.1e-10 40.8 0.2 1.7 2 0 0 2 2 2 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF34167.1 - 8e-06 25.5 0.0 1.5e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_AsnC-type PF13404.1 CCF34167.1 - 0.0027 17.1 0.1 0.0094 15.4 0.1 1.9 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_23 PF13384.1 CCF34167.1 - 0.0075 15.8 0.1 0.023 14.3 0.1 1.8 1 0 0 1 1 1 1 Homeodomain-like domain DDE_1 PF03184.14 CCF34167.1 - 0.01 15.0 0.1 0.016 14.3 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease HTH_24 PF13412.1 CCF34167.1 - 0.075 12.4 0.1 0.18 11.1 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_28 PF13518.1 CCF34167.1 - 0.092 12.7 0.0 0.31 11.1 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_DeoR PF08220.7 CCF34167.1 - 0.12 11.8 0.2 0.36 10.4 0.1 1.8 1 1 0 1 1 1 0 DeoR-like helix-turn-helix domain DUF3505 PF12013.3 CCF34168.1 - 3.1e-07 30.5 0.0 3.6e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3505) Peptidase_M28 PF04389.12 CCF34170.1 - 5.4e-23 81.6 0.1 8.4e-23 81.0 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 CCF34170.1 - 0.0009 18.8 0.1 0.0011 18.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 ABC_tran PF00005.22 CCF34171.1 - 6.5e-47 159.2 0.0 3.4e-23 82.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 CCF34171.1 - 1.8e-21 77.3 0.6 5.6e-05 23.2 0.0 4.3 3 1 1 4 4 4 4 AAA domain ABC_tran_2 PF12848.2 CCF34171.1 - 9.3e-19 67.0 2.5 2.3e-18 65.8 0.7 2.4 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.14 CCF34171.1 - 9.8e-12 44.5 0.2 0.00028 20.2 0.1 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 CCF34171.1 - 3.1e-10 40.7 0.6 0.018 15.3 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.1 CCF34171.1 - 8.9e-10 37.9 0.1 0.00085 18.8 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_17 PF13207.1 CCF34171.1 - 1.7e-06 28.8 0.0 0.018 15.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 CCF34171.1 - 3.2e-06 26.4 0.0 0.004 16.3 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_18 PF13238.1 CCF34171.1 - 2.7e-05 24.4 0.1 0.053 13.8 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.1 CCF34171.1 - 3.4e-05 23.9 0.3 0.18 11.8 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 CCF34171.1 - 4.1e-05 23.7 0.0 0.24 11.5 0.0 2.7 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 CCF34171.1 - 5e-05 23.2 0.0 0.096 12.6 0.0 2.9 3 0 0 3 3 3 2 50S ribosome-binding GTPase NACHT PF05729.7 CCF34171.1 - 8.7e-05 22.2 0.1 0.53 9.9 0.0 2.6 2 0 0 2 2 2 2 NACHT domain Miro PF08477.8 CCF34171.1 - 0.00011 22.7 0.0 0.34 11.4 0.0 2.6 2 0 0 2 2 2 2 Miro-like protein AAA_15 PF13175.1 CCF34171.1 - 0.00025 20.2 0.0 0.098 11.6 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.1 CCF34171.1 - 0.00041 20.3 0.0 0.27 11.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 CCF34171.1 - 0.0005 20.2 0.0 1.1 9.5 0.0 3.1 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CCF34171.1 - 0.00076 19.2 0.1 0.87 9.3 0.1 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) RNA_helicase PF00910.17 CCF34171.1 - 0.0012 19.0 0.0 2.5 8.3 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_33 PF13671.1 CCF34171.1 - 0.0013 18.6 0.1 0.43 10.4 0.0 2.8 3 0 0 3 3 3 1 AAA domain Arch_ATPase PF01637.13 CCF34171.1 - 0.0016 18.1 0.1 1.6 8.3 0.0 2.8 3 0 0 3 3 3 1 Archaeal ATPase AAA_10 PF12846.2 CCF34171.1 - 0.0019 17.6 0.4 0.76 9.1 0.1 2.9 3 0 0 3 3 3 1 AAA-like domain AAA_25 PF13481.1 CCF34171.1 - 0.002 17.5 0.0 0.56 9.5 0.0 2.8 3 0 0 3 3 3 1 AAA domain SbcCD_C PF13558.1 CCF34171.1 - 0.0023 17.8 0.5 0.41 10.6 0.0 3.7 3 2 0 3 3 2 1 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.1 CCF34171.1 - 0.006 16.4 0.0 1.6 8.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 CCF34171.1 - 0.0078 15.9 0.1 0.15 11.8 0.1 2.4 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Dynamin_N PF00350.18 CCF34171.1 - 0.012 15.4 0.3 3.7 7.3 0.0 3.3 3 1 1 4 4 4 0 Dynamin family DUF2813 PF11398.3 CCF34171.1 - 0.013 14.6 0.3 4 6.4 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2813) NB-ARC PF00931.17 CCF34171.1 - 0.013 14.3 0.0 2.3 6.9 0.0 2.7 3 0 0 3 3 3 0 NB-ARC domain DAP3 PF10236.4 CCF34171.1 - 0.017 14.0 0.1 2.9 6.7 0.0 2.6 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 PduV-EutP PF10662.4 CCF34171.1 - 0.052 13.0 0.4 4.2 6.8 0.0 2.8 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.10 CCF34171.1 - 0.11 12.2 0.1 5.9 6.5 0.1 2.5 2 0 0 2 2 2 0 NTPase DUF3584 PF12128.3 CCF34171.1 - 0.14 9.4 0.4 0.35 8.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) AAA_24 PF13479.1 CCF34171.1 - 0.33 10.4 3.1 8.9 5.8 0.0 3.4 4 0 0 4 4 4 0 AAA domain MARVEL PF01284.18 CCF34172.1 - 0.026 14.3 4.3 1.9 8.2 1.0 2.2 2 0 0 2 2 2 0 Membrane-associating domain Methyltransf_23 PF13489.1 CCF34173.1 - 1.2e-14 54.3 0.0 1.7e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF34173.1 - 5.4e-09 36.4 0.0 1.3e-08 35.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF34173.1 - 9.4e-07 29.2 0.0 6.3e-06 26.5 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF34173.1 - 6.8e-06 25.3 0.0 1.2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 CCF34173.1 - 6.4e-05 22.5 0.0 0.00028 20.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF34173.1 - 0.0055 17.2 0.0 0.032 14.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF34173.1 - 0.0089 16.3 0.0 0.029 14.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Herpes_gE PF02480.11 CCF34174.1 - 0.015 13.6 0.0 0.021 13.1 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E AAA PF00004.24 CCF34175.1 - 9.3e-47 158.5 0.0 2.6e-42 144.1 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF34175.1 - 4.3e-08 33.3 0.2 0.00044 20.2 0.1 3.7 3 1 0 3 3 2 2 AAA ATPase domain IstB_IS21 PF01695.12 CCF34175.1 - 2.2e-06 27.2 0.0 8.7e-05 22.0 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_22 PF13401.1 CCF34175.1 - 2.8e-06 27.5 0.2 0.0012 19.0 0.0 4.3 3 1 0 3 3 3 1 AAA domain AAA_2 PF07724.9 CCF34175.1 - 9e-06 25.6 0.0 2.3e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 CCF34175.1 - 0.00075 19.2 0.0 0.0047 16.6 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 CCF34175.1 - 0.00086 20.1 0.0 0.014 16.2 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_19 PF13245.1 CCF34175.1 - 0.0044 16.7 0.1 0.028 14.1 0.1 2.4 1 0 0 1 1 1 1 Part of AAA domain AAA_33 PF13671.1 CCF34175.1 - 0.0062 16.4 7.4 0.0079 16.0 0.0 3.7 4 0 0 4 4 4 1 AAA domain TIP49 PF06068.8 CCF34175.1 - 0.0063 15.2 0.0 0.011 14.5 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus AAA_14 PF13173.1 CCF34175.1 - 0.0073 16.2 0.0 0.027 14.3 0.0 2.0 2 0 0 2 2 1 1 AAA domain RNA_helicase PF00910.17 CCF34175.1 - 0.0075 16.4 0.0 0.054 13.6 0.0 2.4 2 0 0 2 2 2 1 RNA helicase AAA_18 PF13238.1 CCF34175.1 - 0.0092 16.2 0.0 0.049 13.9 0.0 2.4 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 CCF34175.1 - 0.019 14.0 0.0 0.037 13.0 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_28 PF13521.1 CCF34175.1 - 0.021 14.8 0.0 0.064 13.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 CCF34175.1 - 0.028 14.4 0.0 0.16 11.9 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.1 CCF34175.1 - 0.037 13.4 0.0 0.13 11.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain Torsin PF06309.6 CCF34175.1 - 0.039 13.8 0.0 1.4 8.8 0.0 2.4 2 0 0 2 2 2 0 Torsin Mg_chelatase PF01078.16 CCF34175.1 - 0.047 12.8 0.1 0.11 11.6 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Parvo_NS1 PF01057.12 CCF34175.1 - 0.063 12.1 0.2 0.2 10.4 0.0 1.8 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_3 PF07726.6 CCF34175.1 - 0.086 12.4 0.0 0.21 11.1 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 CCF34175.1 - 0.11 11.9 0.0 3.1 7.2 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain DUF3635 PF12330.3 CCF34176.1 - 3.2e-06 27.1 0.0 5.4e-05 23.1 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3635) APH PF01636.18 CCF34176.1 - 0.071 12.8 0.1 0.21 11.2 0.1 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family ARID PF01388.16 CCF34179.1 - 1.4e-18 66.5 0.2 5.5e-18 64.6 0.0 2.1 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain p450 PF00067.17 CCF34180.1 - 1.6e-05 23.6 0.0 1.7e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 T5orf172 PF10544.4 CCF34181.1 - 1.6e-17 63.7 1.1 7.2e-17 61.6 0.3 2.4 2 0 0 2 2 2 1 T5orf172 domain MUG113 PF13455.1 CCF34181.1 - 1.5e-16 60.5 0.8 7e-16 58.4 0.2 2.3 2 0 0 2 2 2 1 Meiotically up-regulated gene 113 Phage_tail PF04630.7 CCF34182.1 - 0.083 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Phage major tail protein DUF2149 PF09919.4 CCF34182.1 - 0.14 12.2 0.4 0.25 11.4 0.1 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) MAP65_ASE1 PF03999.7 CCF34182.1 - 4.2 5.8 7.5 5 5.6 5.2 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Glyco_transf_28 PF03033.15 CCF34185.1 - 1.1e-23 83.5 0.0 2.1e-23 82.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.13 CCF34185.1 - 0.0026 16.3 0.1 0.007 14.9 0.0 1.4 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase RTA1 PF04479.8 CCF34186.1 - 4.7e-58 196.3 1.5 7.1e-58 195.7 1.0 1.2 1 0 0 1 1 1 1 RTA1 like protein Cation_ATPase_C PF00689.16 CCF34186.1 - 0.13 11.7 8.6 0.51 9.8 0.8 2.8 2 2 0 2 2 2 0 Cation transporting ATPase, C-terminus 7TMR-DISM_7TM PF07695.6 CCF34186.1 - 0.29 10.7 13.0 0.067 12.8 2.4 2.3 2 0 0 2 2 2 0 7TM diverse intracellular signalling DUF2759 PF10958.3 CCF34186.1 - 0.34 10.5 8.9 0.28 10.7 0.7 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2759) p450 PF00067.17 CCF34187.1 - 9.9e-49 166.1 0.1 1.2e-48 165.7 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 F-box PF00646.28 CCF34188.1 - 0.0084 15.7 0.1 0.022 14.3 0.1 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 CCF34188.1 - 0.18 11.5 0.1 0.18 11.5 0.1 2.3 3 0 0 3 3 3 0 F-box-like Hamartin PF04388.7 CCF34189.1 - 6.2e-44 150.7 16.2 1.2e-43 149.7 11.2 1.5 1 0 0 1 1 1 1 Hamartin protein Tn7_Tnp_TnsA_C PF08721.6 CCF34189.1 - 0.047 13.6 0.0 0.17 11.9 0.0 2.0 1 0 0 1 1 1 0 TnsA endonuclease C terminal DUF1664 PF07889.7 CCF34189.1 - 2 8.2 14.0 2.9 7.7 1.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4066 PF13278.1 CCF34190.1 - 3.7e-23 81.6 0.3 1.5e-20 73.1 0.1 2.0 2 0 0 2 2 2 2 Putative amidotransferase DJ-1_PfpI PF01965.19 CCF34190.1 - 1.1e-05 24.9 0.0 2.3e-05 23.8 0.0 1.7 1 1 0 1 1 1 1 DJ-1/PfpI family CASP_C PF08172.7 CCF34192.1 - 8.3e-90 300.1 0.0 8.3e-90 300.1 0.0 3.7 2 1 1 3 3 3 1 CASP C terminal SlyX PF04102.7 CCF34192.1 - 0.0078 16.5 0.0 0.0078 16.5 0.0 5.9 7 0 0 7 7 7 1 SlyX Striatin PF08232.7 CCF34192.1 - 0.057 13.7 0.0 0.057 13.7 0.0 5.2 2 1 3 5 5 5 0 Striatin family Med25_VWA PF11265.3 CCF34192.1 - 0.082 11.9 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 25 von Willebrand factor type A DUF4141 PF13605.1 CCF34192.1 - 0.13 11.4 0.1 0.71 9.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4141) IncA PF04156.9 CCF34192.1 - 0.2 11.2 0.1 0.2 11.2 0.0 5.8 3 2 1 5 5 5 0 IncA protein DUF972 PF06156.8 CCF34192.1 - 0.57 10.5 0.0 0.57 10.5 0.0 6.4 4 2 3 7 7 7 0 Protein of unknown function (DUF972) Filament PF00038.16 CCF34192.1 - 2 7.8 49.1 0.56 9.6 14.1 3.8 3 1 1 4 4 4 0 Intermediate filament protein Reo_sigmaC PF04582.7 CCF34192.1 - 4.7 6.2 29.7 1.3 8.1 3.1 5.1 3 1 2 6 6 6 0 Reovirus sigma C capsid protein UPF0180 PF03698.8 CCF34193.1 - 0.031 14.1 0.0 0.078 12.8 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0180) DUF2999 PF11212.3 CCF34193.1 - 0.049 13.6 0.0 0.48 10.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2999) LRR_1 PF00560.28 CCF34193.1 - 0.061 13.3 15.9 9.2 6.7 0.1 7.1 8 0 0 8 8 8 0 Leucine Rich Repeat LRR_7 PF13504.1 CCF34193.1 - 0.8 10.1 18.0 13 6.5 0.0 6.8 6 0 0 6 6 6 0 Leucine rich repeat LRR_6 PF13516.1 CCF34193.1 - 1.6 8.9 17.0 29 5.1 0.4 5.7 6 0 0 6 6 6 0 Leucine Rich repeat Sod_Fe_C PF02777.13 CCF34194.1 - 2.2e-31 107.8 0.1 3.6e-31 107.1 0.1 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 CCF34194.1 - 1.5e-30 105.2 4.4 1.5e-30 105.2 3.0 2.1 2 1 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain NmrA PF05368.8 CCF34196.1 - 9.3e-22 77.4 0.0 1.3e-21 76.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF34196.1 - 3.9e-13 49.7 0.1 8.9e-13 48.6 0.1 1.7 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF34196.1 - 2.2e-08 33.8 0.1 2e-06 27.4 0.1 2.5 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.5 CCF34196.1 - 5.9e-05 22.8 0.1 9.2e-05 22.1 0.1 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 CCF34196.1 - 0.0001 22.2 0.2 0.00018 21.5 0.2 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Saccharop_dh PF03435.13 CCF34196.1 - 0.00023 20.2 0.1 0.00048 19.2 0.1 1.5 2 0 0 2 2 2 1 Saccharopine dehydrogenase TrkA_N PF02254.13 CCF34196.1 - 0.0016 18.3 0.1 0.0037 17.2 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain Polysacc_synt_2 PF02719.10 CCF34196.1 - 0.0072 15.2 0.5 0.017 14.0 0.2 1.6 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.15 CCF34196.1 - 0.0072 16.4 0.1 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_4 PF07993.7 CCF34196.1 - 0.051 12.4 0.0 0.074 11.9 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein F420_oxidored PF03807.12 CCF34196.1 - 0.071 13.5 0.6 0.34 11.3 0.2 2.2 1 1 1 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent 3Beta_HSD PF01073.14 CCF34196.1 - 0.08 11.6 0.0 0.13 10.9 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family ThiF PF00899.16 CCF34196.1 - 0.2 11.4 0.5 0.68 9.7 0.3 1.9 1 1 0 1 1 1 0 ThiF family DapB_N PF01113.15 CCF34196.1 - 0.77 9.6 2.9 6.6 6.6 2.0 2.2 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus zf-C3HC4_3 PF13920.1 CCF34197.1 - 1.6e-05 24.4 9.9 2.2e-05 24.0 6.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF34197.1 - 0.002 17.7 13.1 0.0028 17.2 9.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Cript PF10235.4 CCF34197.1 - 0.061 13.6 0.7 0.088 13.1 0.5 1.3 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT C1_3 PF07649.7 CCF34197.1 - 0.19 11.7 5.3 8.1 6.5 1.4 2.3 2 0 0 2 2 2 0 C1-like domain zf-RING_5 PF14634.1 CCF34197.1 - 0.25 11.1 11.6 0.38 10.5 8.0 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.1 CCF34197.1 - 0.3 10.9 11.5 0.42 10.4 7.9 1.2 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.1 CCF34197.1 - 0.42 10.6 12.7 0.61 10.1 8.8 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.1 CCF34197.1 - 0.8 9.3 9.3 1.6 8.3 6.4 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain SWIB PF02201.13 CCF34198.1 - 3.3e-28 97.1 0.3 1.6e-27 95.0 0.1 2.0 2 0 0 2 2 2 1 SWIB/MDM2 domain DEK_C PF08766.6 CCF34198.1 - 5e-16 58.2 1.1 8.3e-15 54.3 0.4 2.3 2 0 0 2 2 2 1 DEK C terminal domain BTV_NS2 PF04514.7 CCF34198.1 - 0.38 9.5 6.6 0.53 9.1 4.6 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 adh_short PF00106.20 CCF34199.1 - 2.4e-14 53.6 0.1 3.6e-14 53.0 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF34199.1 - 8.2e-07 28.8 0.1 1.5e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF34199.1 - 0.00013 22.0 0.3 0.00041 20.4 0.2 1.9 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF34199.1 - 0.00028 20.3 0.0 0.00044 19.7 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 CCF34199.1 - 0.0054 16.5 0.0 0.0083 15.9 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase THF_DHG_CYH_C PF02882.14 CCF34199.1 - 0.0058 15.7 0.0 0.01 14.9 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NDT80_PhoG PF05224.7 CCF34201.1 - 7.2e-45 153.2 0.0 1.2e-44 152.6 0.0 1.3 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Fe-ADH PF00465.14 CCF34202.1 - 1e-65 221.7 0.7 1.2e-65 221.5 0.5 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.1 CCF34202.1 - 8.3e-19 67.8 0.1 1.1e-18 67.4 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase WD40 PF00400.27 CCF34203.1 - 3.2e-10 39.4 4.5 0.0019 18.0 0.2 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat CDC45 PF02724.9 CCF34203.1 - 0.17 9.8 6.9 0.24 9.4 4.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.7 CCF34203.1 - 8 4.2 9.1 11 3.8 6.3 1.1 1 0 0 1 1 1 0 Nop14-like family Glyco_hydro_18 PF00704.23 CCF34204.1 - 2.2e-51 175.3 0.1 2.7e-51 175.0 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DRIM PF07539.7 CCF34205.1 - 5.6e-41 139.2 0.0 2e-40 137.4 0.0 2.1 1 0 0 1 1 1 1 Down-regulated in metastasis HEAT PF02985.17 CCF34205.1 - 0.00033 20.4 4.8 7.9 6.8 0.1 7.7 7 0 0 7 7 7 1 HEAT repeat zf-DNL PF05180.7 CCF34206.1 - 2.7e-28 97.4 0.3 3.7e-28 97.0 0.2 1.2 1 0 0 1 1 1 1 DNL zinc finger zf-CSL PF05207.8 CCF34206.1 - 0.04 13.4 0.2 0.07 12.6 0.2 1.3 1 0 0 1 1 1 0 CSL zinc finger C2 PF00168.25 CCF34207.1 - 1.1e-70 233.5 1.7 4.9e-22 77.5 0.1 5.6 5 0 0 5 5 5 5 C2 domain DUF2404 PF10296.4 CCF34207.1 - 0.043 13.9 0.0 0.13 12.3 0.0 1.8 1 0 0 1 1 1 0 Putative integral membrane protein conserved region (DUF2404) Proteasome PF00227.21 CCF34208.1 - 7.7e-48 162.2 0.1 9.2e-48 162.0 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF554 PF04474.7 CCF34208.1 - 0.0022 17.2 0.1 0.0031 16.6 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF554) DUF3222 PF11519.3 CCF34208.1 - 0.027 14.4 0.5 6.4 6.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3222) FHA PF00498.21 CCF34210.1 - 3.5e-07 30.2 0.0 8.2e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 FHA domain Trypan_PARP PF05887.6 CCF34210.1 - 5.3e-06 26.2 22.5 5.3e-06 26.2 15.6 3.3 2 1 1 3 3 3 1 Procyclic acidic repetitive protein (PARP) Mannosyl_trans PF05007.8 CCF34211.1 - 1.4e-76 257.6 14.0 1.8e-76 257.2 9.7 1.1 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.8 CCF34211.1 - 4.7e-09 35.6 13.3 4.6e-08 32.3 9.2 2.3 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U DUF2029 PF09594.5 CCF34211.1 - 1.8e-05 24.3 18.8 1.8e-05 24.3 13.0 2.5 2 1 0 3 3 3 1 Protein of unknown function (DUF2029) Translin PF01997.11 CCF34212.1 - 5.1e-50 169.8 0.1 6e-50 169.6 0.1 1.0 1 0 0 1 1 1 1 Translin family Senescence PF06911.7 CCF34212.1 - 0.0072 16.0 0.0 0.018 14.7 0.0 1.6 2 0 0 2 2 2 1 Senescence-associated protein FliJ PF02050.11 CCF34212.1 - 0.011 15.7 0.4 0.022 14.8 0.1 1.6 2 0 0 2 2 2 0 Flagellar FliJ protein Baculo_PEP_C PF04513.7 CCF34212.1 - 0.018 14.8 0.1 0.039 13.7 0.0 1.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.7 CCF34212.1 - 0.031 14.5 0.1 0.47 10.7 0.0 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein tRNA-synt_2 PF00152.15 CCF34213.1 - 1.4e-68 231.1 0.0 1.8e-68 230.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 CCF34213.1 - 0.0029 17.4 0.1 0.0077 16.0 0.0 1.8 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RTA1 PF04479.8 CCF34216.1 - 3e-42 144.6 10.6 3.6e-42 144.3 7.3 1.0 1 0 0 1 1 1 1 RTA1 like protein HlyIII PF03006.15 CCF34216.1 - 0.23 10.8 9.9 0.64 9.3 6.9 1.8 1 1 0 1 1 1 0 Haemolysin-III related Kei1 PF08552.6 CCF34216.1 - 1.4 8.4 5.9 0.22 11.1 1.2 1.7 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 DSPc PF00782.15 CCF34218.1 - 3.7e-09 36.2 0.0 7.5e-09 35.2 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 CCF34218.1 - 0.0002 20.8 0.0 0.0004 19.8 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 CCF34218.1 - 0.0041 17.3 0.0 0.0087 16.3 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Fungal_trans PF04082.13 CCF34219.1 - 0.00072 18.5 0.0 0.0029 16.5 0.0 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain AAA PF00004.24 CCF34220.1 - 5.6e-19 68.6 0.0 8.8e-19 68.0 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CCF34220.1 - 0.00046 20.3 0.4 0.063 13.4 0.3 2.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CCF34220.1 - 0.028 15.2 0.5 0.098 13.4 0.1 2.2 2 1 0 2 2 2 0 AAA domain ArgK PF03308.11 CCF34220.1 - 0.039 12.7 0.0 0.06 12.1 0.0 1.2 1 0 0 1 1 1 0 ArgK protein AAA_5 PF07728.9 CCF34220.1 - 0.088 12.5 0.0 0.62 9.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 CCF34220.1 - 0.15 12.0 0.6 0.37 10.7 0.4 1.7 1 1 0 1 1 1 0 AAA ATPase domain Metallophos PF00149.23 CCF34221.1 - 3e-44 150.8 1.0 3.9e-44 150.4 0.7 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF3112 PF11309.3 CCF34222.1 - 1.8e-36 125.3 7.5 1.8e-36 125.3 5.2 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3112) PS_Dcarbxylase PF02666.10 CCF34224.1 - 1.9e-52 177.4 0.0 3.2e-52 176.7 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.25 CCF34224.1 - 1e-33 115.0 0.6 1.5e-16 59.9 0.0 2.8 2 0 0 2 2 2 2 C2 domain EF-hand_7 PF13499.1 CCF34224.1 - 0.0028 17.7 0.2 0.0091 16.1 0.2 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 CCF34224.1 - 0.0035 16.6 0.0 0.026 13.8 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.27 CCF34224.1 - 0.0064 15.7 0.0 0.027 13.7 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 CCF34224.1 - 0.023 14.5 0.1 0.12 12.3 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain CEP76-C2 PF15627.1 CCF34224.1 - 0.075 12.5 0.0 0.31 10.5 0.0 2.0 2 0 0 2 2 2 0 CEP76 C2 domain Abhydrolase_1 PF00561.15 CCF34225.1 - 7.1e-32 110.8 0.0 1.7e-31 109.5 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF34225.1 - 1.3e-08 34.9 1.5 3.1e-08 33.7 1.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family AA_kinase PF00696.23 CCF34226.1 - 2.8e-34 118.7 0.0 8.1e-34 117.2 0.0 1.8 2 1 0 2 2 2 1 Amino acid kinase family ACT_7 PF13840.1 CCF34226.1 - 5e-11 41.9 3.5 1.7e-10 40.2 2.1 2.1 2 0 0 2 2 2 1 ACT domain ACT PF01842.20 CCF34226.1 - 1.5e-06 27.5 0.6 3.4e-06 26.3 0.4 1.6 1 0 0 1 1 1 1 ACT domain Cellulase PF00150.13 CCF34228.1 - 2.2e-11 43.5 3.5 5.5e-09 35.6 2.4 2.5 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Sugar_tr PF00083.19 CCF34229.1 - 2e-74 250.7 15.1 2.6e-74 250.4 10.5 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF34229.1 - 5.4e-12 45.0 42.3 6.2e-08 31.7 12.5 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Cache_2 PF08269.6 CCF34231.1 - 0.11 12.4 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 Cache domain 4HBT PF03061.17 CCF34233.1 - 1.2e-13 50.9 0.0 1.7e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.1 CCF34233.1 - 0.0059 16.3 0.0 0.0063 16.2 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily DUF4442 PF14539.1 CCF34233.1 - 0.0098 15.8 0.0 0.013 15.4 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4442) Tfb2 PF03849.9 CCF34234.1 - 3.4e-96 322.0 0.0 3.9e-96 321.8 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Tfb2 IMPDH PF00478.20 CCF34235.1 - 4.9e-132 440.0 0.9 6e-132 439.8 0.6 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.23 CCF34235.1 - 6.7e-16 57.8 0.0 2.2e-07 30.5 0.0 2.4 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.13 CCF34235.1 - 5.5e-11 41.9 0.7 6.7e-09 35.0 0.5 2.3 2 0 0 2 2 2 2 FMN-dependent dehydrogenase NMO PF03060.10 CCF34235.1 - 2.3e-10 40.1 0.5 0.00024 20.3 0.4 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase His_biosynth PF00977.16 CCF34235.1 - 0.00023 20.4 4.3 0.024 13.9 0.2 3.1 2 1 1 3 3 3 2 Histidine biosynthesis protein ThiG PF05690.9 CCF34235.1 - 0.066 12.2 3.1 0.15 11.1 0.4 2.4 1 1 2 3 3 3 0 Thiazole biosynthesis protein ThiG IQ PF00612.22 CCF34236.1 - 1.6e-15 55.1 18.6 0.0077 15.7 0.1 11.3 11 0 0 11 11 11 5 IQ calmodulin-binding motif CH PF00307.26 CCF34236.1 - 1e-10 41.5 0.0 2e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain Stc1 PF12898.2 CCF34238.1 - 8.4e-15 54.5 0.8 8.4e-15 54.5 0.5 2.0 2 0 0 2 2 2 1 Stc1 domain BCDHK_Adom3 PF10436.4 CCF34239.1 - 7.3e-69 230.4 0.0 1.1e-68 229.8 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 CCF34239.1 - 2.8e-14 52.7 0.0 6e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 CCF34239.1 - 0.01 15.4 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF964 PF06133.6 CCF34240.1 - 0.00034 20.6 1.7 0.00059 19.8 1.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF964) Spc24 PF08286.6 CCF34240.1 - 0.53 9.9 6.9 0.41 10.3 3.2 1.9 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 PRA1 PF03208.14 CCF34242.1 - 2.5 7.4 13.3 0.17 11.2 4.4 2.4 1 1 1 2 2 2 0 PRA1 family protein MFS_1 PF07690.11 CCF34243.1 - 6e-18 64.6 43.1 6.4e-10 38.2 18.7 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF34243.1 - 1.4e-10 40.0 17.8 2.9e-10 38.9 12.4 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) RabGAP-TBC PF00566.13 CCF34244.1 - 6.4e-47 159.7 0.0 2e-46 158.1 0.0 1.7 1 1 0 1 1 1 1 Rab-GTPase-TBC domain DEC-1_N PF04625.8 CCF34245.1 - 2.7 6.5 7.8 3.5 6.2 5.4 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region RRM_1 PF00076.17 CCF34246.1 - 2.1e-38 129.7 0.2 4.2e-18 64.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF34246.1 - 1.7e-28 98.3 1.8 4.7e-14 52.1 0.0 2.6 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF34246.1 - 4.7e-13 48.7 0.0 2.6e-05 23.9 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CCF34246.1 - 0.0021 17.7 0.0 2.7 7.8 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 CCF34246.1 - 0.096 12.5 1.3 9.2 6.1 0.0 2.8 3 0 0 3 3 3 0 RNA binding motif SOBP PF15279.1 CCF34246.1 - 0.12 12.7 13.6 0.19 12.0 9.4 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Rhabdo_glycop PF00974.13 CCF34246.1 - 3.7 5.6 6.2 5.3 5.1 4.3 1.2 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein Sigma_reg_N PF13800.1 CCF34248.1 - 0.031 14.2 1.0 0.053 13.5 0.7 1.3 1 0 0 1 1 1 0 Sigma factor regulator N-terminal YtpI PF14007.1 CCF34248.1 - 0.075 12.9 1.1 0.12 12.3 0.8 1.3 1 0 0 1 1 1 0 YtpI-like protein DUF1422 PF07226.6 CCF34248.1 - 0.087 12.5 2.0 0.082 12.6 0.6 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1422) GMC_oxred_C PF05199.8 CCF34249.1 - 1.1e-15 58.1 0.0 1.3e-15 57.9 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase Asn_synthase PF00733.16 CCF34250.1 - 1.1e-48 165.9 0.0 4e-48 164.1 0.0 1.9 2 0 0 2 2 2 1 Asparagine synthase GATase_7 PF13537.1 CCF34250.1 - 1.6e-35 121.5 0.0 3.3e-35 120.5 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 CCF34250.1 - 2.2e-30 105.3 0.0 7.4e-30 103.6 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.3 CCF34250.1 - 2.6e-05 23.5 0.2 8.3e-05 21.9 0.0 1.8 2 0 0 2 2 2 1 Aluminium induced protein NAD_synthase PF02540.12 CCF34250.1 - 0.054 12.4 0.0 0.086 11.7 0.0 1.3 1 0 0 1 1 1 0 NAD synthase PYST-C1 PF09690.5 CCF34250.1 - 0.078 12.6 1.4 0.17 11.5 1.0 1.4 1 0 0 1 1 1 0 Plasmodium yoelii subtelomeric region (PYST-C1) Nucleoplasmin PF03066.10 CCF34250.1 - 0.14 11.6 1.1 0.23 10.9 0.7 1.2 1 0 0 1 1 1 0 Nucleoplasmin Cwf_Cwc_15 PF04889.7 CCF34250.1 - 0.46 10.1 2.1 0.85 9.2 1.4 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Clathrin PF00637.15 CCF34251.1 - 1.7e-13 50.3 1.4 3.7e-09 36.3 0.0 2.9 3 0 0 3 3 3 2 Region in Clathrin and VPS zf-RING_2 PF13639.1 CCF34251.1 - 9.2e-05 22.1 0.4 9.2e-05 22.1 0.3 2.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 CCF34251.1 - 0.00042 19.9 0.4 0.00042 19.9 0.3 1.9 2 0 0 2 2 2 1 zinc-RING finger domain DUF2175 PF09943.4 CCF34251.1 - 0.0033 17.4 0.0 0.01 15.8 0.0 1.8 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2175) zf-C3HC4_2 PF13923.1 CCF34251.1 - 0.034 14.1 0.4 0.034 14.1 0.3 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.9 CCF34251.1 - 0.061 12.8 0.2 5.8 6.4 0.1 2.9 2 0 0 2 2 2 0 Rad50 zinc hook motif Vps39_2 PF10367.4 CCF34251.1 - 0.073 13.2 0.0 0.19 11.9 0.0 1.8 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-C3HC4 PF00097.20 CCF34251.1 - 0.1 12.2 0.2 0.1 12.2 0.1 2.2 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) adh_short PF00106.20 CCF34253.1 - 5.2e-32 111.0 0.3 7e-32 110.6 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF34253.1 - 4.1e-18 66.0 0.0 5.1e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF34253.1 - 2.5e-16 59.8 1.2 5.2e-16 58.8 0.9 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF34253.1 - 0.00026 20.5 0.1 0.00051 19.5 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF34253.1 - 0.0059 16.6 0.8 0.038 14.0 0.3 2.4 2 1 0 2 2 2 1 NADH(P)-binding Glyco_transf_5 PF08323.6 CCF34253.1 - 0.0073 15.8 0.0 0.095 12.1 0.0 2.2 2 1 0 2 2 2 1 Starch synthase catalytic domain F420_oxidored PF03807.12 CCF34253.1 - 0.029 14.7 0.8 0.22 11.9 0.5 2.3 1 1 1 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Eno-Rase_NADH_b PF12242.3 CCF34253.1 - 0.041 13.6 0.1 0.085 12.6 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Toprim_3 PF13362.1 CCF34253.1 - 0.052 13.7 0.0 0.79 10.0 0.0 2.4 2 1 0 2 2 2 0 Toprim domain Glyco_trans_4_4 PF13579.1 CCF34253.1 - 0.056 13.5 1.5 4.9 7.2 0.0 2.4 3 0 0 3 3 3 0 Glycosyl transferase 4-like domain ApbA PF02558.11 CCF34253.1 - 0.1 12.0 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.13 CCF34253.1 - 0.12 12.3 0.2 0.19 11.7 0.1 1.3 1 0 0 1 1 1 0 TrkA-N domain MR_MLE_N PF02746.11 CCF34254.1 - 3.3e-21 75.4 0.0 6.1e-21 74.6 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MR_MLE_C PF13378.1 CCF34254.1 - 8.6e-20 70.7 0.2 6.9e-19 67.8 0.0 2.1 2 0 0 2 2 2 1 Enolase C-terminal domain-like MR_MLE PF01188.16 CCF34254.1 - 3.9e-10 40.1 0.0 8.3e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MFS_1 PF07690.11 CCF34255.1 - 5.8e-53 179.8 37.2 4.3e-52 176.9 25.2 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF34255.1 - 6.1e-13 48.1 22.6 1.7e-11 43.3 7.8 2.9 3 1 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.8 CCF34255.1 - 5.6e-11 41.3 20.4 8e-11 40.8 14.0 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF4245 PF14030.1 CCF34255.1 - 0.27 10.9 1.9 1.4 8.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4245) Pkinase PF00069.20 CCF34256.1 - 2.1e-26 92.6 0.1 2.4e-26 92.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF34256.1 - 1.1e-17 63.9 0.0 1.4e-17 63.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Transglut_core PF01841.14 CCF34257.1 - 2.2e-11 43.9 0.4 6.2e-11 42.5 0.3 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily SH3_2 PF07653.12 CCF34257.1 - 9.7e-09 34.5 0.4 2e-08 33.6 0.3 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 CCF34257.1 - 4.7e-05 22.6 0.1 4.7e-05 22.6 0.1 2.4 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.1 CCF34257.1 - 9.6e-05 21.8 0.3 0.00021 20.8 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain DUF883 PF05957.8 CCF34258.1 - 0.064 13.6 7.1 8.3 6.8 3.8 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Ribosomal_L32e PF01655.13 CCF34260.1 - 3.2e-49 165.5 1.9 4.2e-49 165.1 1.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 MIP-T3 PF10243.4 CCF34261.1 - 0.73 8.2 22.3 0.98 7.8 15.5 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 PTCB-BRCT PF12738.2 CCF34262.1 - 9.3e-44 147.1 0.0 1e-19 70.0 0.0 3.4 3 0 0 3 3 3 3 twin BRCT domain BRCT PF00533.21 CCF34262.1 - 1e-34 118.4 0.1 2.4e-11 43.6 0.0 5.0 5 1 0 5 5 5 4 BRCA1 C Terminus (BRCT) domain SAC3_GANP PF03399.11 CCF34263.1 - 6.4e-65 218.5 0.1 8.7e-65 218.0 0.1 1.2 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 CCF34263.1 - 0.0061 16.3 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 EAP30 PF04157.11 CCF34264.1 - 3.2e-56 189.9 0.0 4.1e-56 189.6 0.0 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.3 CCF34264.1 - 1.2e-25 89.1 0.0 1.9e-25 88.4 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 zf-Sec23_Sec24 PF04810.10 CCF34264.1 - 0.00083 18.8 4.3 0.014 14.9 0.2 2.5 2 0 0 2 2 2 2 Sec23/Sec24 zinc finger GRAM PF02893.15 CCF34264.1 - 0.002 17.6 0.0 0.004 16.6 0.0 1.4 1 0 0 1 1 1 1 GRAM domain zf-RanBP PF00641.13 CCF34264.1 - 0.0076 15.3 12.9 0.01 14.9 0.6 2.7 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others DZR PF12773.2 CCF34264.1 - 2.6 7.9 8.3 0.092 12.5 0.9 2.1 2 1 0 2 2 2 0 Double zinc ribbon RAI16-like PF10257.4 CCF34265.1 - 3.6e-82 276.1 2.2 4.7e-82 275.7 1.5 1.1 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein RhoGEF PF00621.15 CCF34266.1 - 5.8e-32 111.0 0.9 8.7e-32 110.4 0.6 1.3 1 0 0 1 1 1 1 RhoGEF domain Mito_carr PF00153.22 CCF34267.1 - 2.8e-62 206.4 0.3 8.5e-20 70.2 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein SPRY PF00622.23 CCF34268.1 - 6.1e-08 32.7 0.1 5.6e-07 29.6 0.0 2.6 3 0 0 3 3 3 1 SPRY domain DUF3069 PF11269.3 CCF34269.1 - 0.069 13.2 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3069) YjbE PF11106.3 CCF34269.1 - 0.8 9.7 5.7 1.6 8.7 0.0 2.9 3 0 0 3 3 3 0 Exopolysaccharide production protein YjbE SMC_Nse1 PF07574.8 CCF34270.1 - 6.3e-37 127.1 0.1 8.1e-37 126.8 0.0 1.1 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.6 CCF34270.1 - 1.3e-11 44.2 12.8 2.1e-11 43.6 8.9 1.3 1 0 0 1 1 1 1 RING-like domain FadR_C PF07840.7 CCF34270.1 - 0.018 14.6 0.1 0.03 13.9 0.1 1.3 1 0 0 1 1 1 0 FadR C-terminal domain Mrr_N PF14338.1 CCF34270.1 - 0.02 14.9 0.0 0.8 9.8 0.0 2.3 2 0 0 2 2 2 0 Mrr N-terminal domain zf-RING_2 PF13639.1 CCF34270.1 - 8.5 6.3 9.0 16 5.3 6.2 1.5 1 0 0 1 1 1 0 Ring finger domain Clr2 PF10383.4 CCF34272.1 - 5e-09 36.2 0.0 1.5e-08 34.7 0.0 1.8 1 0 0 1 1 1 1 Transcription-silencing protein Clr2 CAP59_mtransfer PF11735.3 CCF34275.1 - 9.5e-58 195.2 0.0 1.3e-57 194.7 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 NUDE_C PF04880.8 CCF34276.1 - 2.2 8.5 9.4 2.7 8.3 6.5 1.1 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Ubie_methyltran PF01209.13 CCF34277.1 - 7.8e-16 57.8 0.0 1.1e-15 57.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 CCF34277.1 - 1.1e-14 54.6 0.0 1.9e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF34277.1 - 1.6e-14 53.7 0.0 2.2e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF34277.1 - 3.1e-13 49.9 0.1 8.5e-13 48.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF34277.1 - 1.3e-08 34.7 0.0 1.9e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF34277.1 - 1.4e-06 28.7 0.0 2e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF34277.1 - 1.3e-05 25.1 0.1 4.2e-05 23.5 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_8 PF05148.10 CCF34277.1 - 1.5e-05 24.7 0.0 3e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.9 CCF34277.1 - 3.7e-05 23.1 0.0 6.4e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.2 CCF34277.1 - 0.00032 21.2 0.0 0.00053 20.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 CCF34277.1 - 0.0029 17.0 0.0 0.011 15.1 0.0 1.8 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW PCMT PF01135.14 CCF34277.1 - 0.16 11.4 0.0 0.26 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Lipocalin_5 PF13924.1 CCF34278.1 - 3.4e-24 85.1 0.0 3.9e-24 84.9 0.0 1.0 1 0 0 1 1 1 1 Lipocalin-like domain zf-C2H2_2 PF12756.2 CCF34279.1 - 2.1e-26 91.9 1.7 4.3e-26 90.9 1.2 1.5 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) DUF1989 PF09347.5 CCF34280.1 - 3.5e-55 185.9 0.0 4.5e-55 185.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) Cse1 PF08506.5 CCF34281.1 - 3.5e-09 35.7 0.3 4.8e-08 31.9 0.0 2.5 1 1 0 2 2 2 1 Cse1 Vac14_Fab1_bd PF12755.2 CCF34281.1 - 0.0021 18.3 0.7 3.8 7.9 0.0 4.1 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region DUF2435 PF10363.4 CCF34281.1 - 0.023 14.5 0.2 0.064 13.1 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2435) HEAT PF02985.17 CCF34281.1 - 0.094 12.8 0.1 0.58 10.3 0.1 2.5 1 0 0 1 1 1 0 HEAT repeat WH2 PF02205.15 CCF34283.1 - 0.014 14.9 0.1 0.027 14.0 0.1 1.5 1 0 0 1 1 1 0 WH2 motif eIF-1a PF01176.14 CCF34284.1 - 3e-27 93.8 0.2 4.2e-27 93.3 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Myb_DNA-bind_6 PF13921.1 CCF34284.1 - 0.076 13.1 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain Glyco_hydro_2_C PF02836.12 CCF34285.1 - 0.028 13.3 0.0 0.041 12.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain BRCT PF00533.21 CCF34286.1 - 3.7e-12 46.2 0.0 7.1e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 CCF34286.1 - 5.4e-12 45.3 0.1 1.1e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain fn3 PF00041.16 CCF34286.1 - 0.00055 20.0 0.0 0.0016 18.5 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III domain DUF3006 PF11213.3 CCF34286.1 - 0.039 13.7 0.3 0.14 11.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3006) Hid1 PF12722.2 CCF34286.1 - 3.1 5.3 8.3 4 4.9 5.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein adh_short PF00106.20 CCF34287.1 - 4.8e-11 42.8 1.7 9.8e-10 38.6 0.2 2.1 1 1 1 2 2 2 1 short chain dehydrogenase KR PF08659.5 CCF34287.1 - 5.1e-06 26.2 0.1 7.7e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF34287.1 - 0.004 16.9 0.0 0.0057 16.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase p450 PF00067.17 CCF34289.1 - 2.4e-75 253.8 0.2 3.4e-75 253.3 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 Ank_2 PF12796.2 CCF34291.1 - 3.2e-39 133.1 0.1 1.4e-12 47.8 0.1 4.5 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 CCF34291.1 - 1.3e-35 119.4 0.1 1e-06 28.2 0.0 7.6 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.1 CCF34291.1 - 3.3e-28 97.0 0.3 7.3e-08 32.4 0.0 6.7 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF34291.1 - 6.4e-28 94.0 0.2 0.00011 22.0 0.0 7.7 7 0 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.1 CCF34291.1 - 3e-25 88.0 1.5 3.6e-05 24.1 0.0 6.7 4 2 2 6 6 6 5 Ankyrin repeats (many copies) Shigella_OspC PF06128.6 CCF34291.1 - 0.14 11.6 0.0 2.2 7.7 0.0 2.6 3 0 0 3 3 3 0 Shigella flexneri OspC protein FtsJ PF01728.14 CCF34292.1 - 3.2e-12 46.8 0.0 6.7e-12 45.7 0.0 1.5 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_18 PF12847.2 CCF34292.1 - 0.0055 17.2 0.0 0.02 15.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF34292.1 - 0.018 15.1 0.0 0.043 13.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Nol1_Nop2_Fmu PF01189.12 CCF34292.1 - 0.021 14.2 0.0 0.076 12.3 0.0 1.9 2 0 0 2 2 2 0 NOL1/NOP2/sun family SPO22 PF08631.5 CCF34294.1 - 1.5e-58 198.1 0.3 1.8e-55 188.0 0.0 3.6 4 0 0 4 4 4 2 Meiosis protein SPO22/ZIP4 like TPR_2 PF07719.12 CCF34294.1 - 0.18 11.7 2.3 1.4 9.0 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.1 CCF34294.1 - 2 8.7 8.8 0.52 10.6 0.2 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Pyridoxal_deC PF00282.14 CCF34295.1 - 4.5e-76 255.7 0.0 5.7e-76 255.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DegT_DnrJ_EryC1 PF01041.12 CCF34295.1 - 0.13 11.2 0.1 0.29 10.1 0.0 1.5 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Lactamase_B PF00753.22 CCF34296.1 - 7e-21 74.7 0.5 9.3e-21 74.3 0.4 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CCF34296.1 - 3.9e-05 23.2 0.0 5.6e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Sulf_transp PF04143.9 CCF34297.1 - 1e-14 54.2 27.6 3.7e-11 42.8 7.6 4.0 4 1 0 4 4 4 2 Sulphur transport Ribonuc_L-PSP PF01042.16 CCF34298.1 - 4e-27 94.3 0.8 4.4e-27 94.2 0.5 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF1320 PF07030.7 CCF34298.1 - 0.0024 17.6 0.1 0.0032 17.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1320) BID PF06393.6 CCF34298.1 - 0.036 13.4 0.0 0.049 12.9 0.0 1.2 1 0 0 1 1 1 0 BH3 interacting domain (BID) SAP PF02037.22 CCF34299.1 - 8.6e-08 31.5 0.3 1.4e-07 30.8 0.2 1.4 1 0 0 1 1 1 1 SAP domain SWIM PF04434.12 CCF34299.1 - 0.0011 18.4 0.3 0.0029 17.0 0.2 1.8 1 0 0 1 1 1 1 SWIM zinc finger zf-RING_2 PF13639.1 CCF34299.1 - 0.0031 17.3 13.6 0.0031 17.3 9.4 1.8 2 0 0 2 2 2 1 Ring finger domain PHD PF00628.24 CCF34299.1 - 0.034 13.8 12.7 0.11 12.2 8.8 1.9 1 1 0 1 1 1 0 PHD-finger Rad50_zn_hook PF04423.9 CCF34299.1 - 0.3 10.6 3.1 1.4 8.4 0.6 2.6 2 0 0 2 2 2 0 Rad50 zinc hook motif LZ_Tnp_IS66 PF13007.2 CCF34299.1 - 0.35 11.5 2.3 2.3 8.9 0.3 2.5 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain Aminotran_1_2 PF00155.16 CCF34300.1 - 1.6e-60 204.9 0.0 2.1e-60 204.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 CCF34300.1 - 0.039 13.0 0.0 0.06 12.4 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 CCF34300.1 - 0.23 10.4 0.0 0.38 9.7 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Sugar_tr PF00083.19 CCF34302.1 - 2.2e-77 260.5 24.1 2.5e-77 260.3 16.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF34302.1 - 5e-24 84.6 34.7 2.7e-22 78.9 17.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_A4 PF01828.12 CCF34303.1 - 2.2e-71 239.2 10.9 2.7e-71 238.9 7.6 1.1 1 0 0 1 1 1 1 Peptidase A4 family Arteri_nucleo PF01481.11 CCF34303.1 - 0.034 14.2 0.0 0.06 13.4 0.0 1.3 1 0 0 1 1 1 0 Arterivirus nucleocapsid protein HLH PF00010.21 CCF34306.1 - 2.9e-12 46.1 0.0 8.6e-12 44.5 0.0 1.8 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF3734 PF12536.3 CCF34306.1 - 0.016 15.3 0.9 0.64 10.1 0.1 2.4 2 0 0 2 2 2 0 Patatin phospholipase NPR3 PF03666.8 CCF34307.1 - 3.7e-136 454.2 0.2 5.2e-136 453.7 0.1 1.2 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 NPR2 PF06218.6 CCF34307.1 - 0.014 14.1 0.1 0.024 13.3 0.1 1.3 1 0 0 1 1 1 0 Nitrogen permease regulator 2 ATHILA PF03078.10 CCF34307.1 - 0.065 11.8 4.3 0.1 11.1 2.9 1.2 1 0 0 1 1 1 0 ATHILA ORF-1 family ERp29 PF07749.7 CCF34307.1 - 2.4 8.8 6.2 0.82 10.3 0.5 2.6 2 0 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain WD40 PF00400.27 CCF34308.1 - 7.1e-18 63.7 2.5 8.9e-08 31.7 0.1 4.2 5 0 0 5 5 5 3 WD domain, G-beta repeat PQQ_2 PF13360.1 CCF34308.1 - 0.0098 15.3 0.1 0.11 11.9 0.0 2.2 1 1 0 1 1 1 1 PQQ-like domain ELO PF01151.13 CCF34310.1 - 2.6e-59 200.5 12.1 3.2e-59 200.2 8.4 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family Colicin_V PF02674.11 CCF34310.1 - 1.2 9.0 7.8 1.6 8.5 0.2 2.4 2 0 0 2 2 2 0 Colicin V production protein 4HBT_2 PF13279.1 CCF34311.1 - 4.7e-10 39.9 0.0 1e-09 38.8 0.0 1.5 1 0 0 1 1 1 1 Thioesterase-like superfamily MFS_1 PF07690.11 CCF34312.1 - 8.3e-15 54.3 16.2 1.2e-14 53.7 11.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF34312.1 - 1.5e-07 30.3 2.2 2.1e-07 29.9 1.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter PBP1_TM PF14812.1 CCF34312.1 - 1.9 8.8 7.5 35 4.7 4.9 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cwf_Cwc_15 PF04889.7 CCF34312.1 - 6 6.5 14.4 0.93 9.1 6.5 1.9 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Abhydrolase_3 PF07859.8 CCF34314.1 - 4.4e-55 186.5 0.0 6.7e-55 185.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF34314.1 - 0.00011 21.5 0.0 0.047 12.9 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Esterase_phd PF10503.4 CCF34314.1 - 0.0025 17.0 0.5 0.0041 16.3 0.3 1.2 1 0 0 1 1 1 1 Esterase PHB depolymerase COesterase PF00135.23 CCF34314.1 - 0.0058 15.3 0.3 0.014 14.1 0.2 1.5 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_5 PF12695.2 CCF34314.1 - 0.027 14.2 0.0 0.047 13.4 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S15 PF02129.13 CCF34314.1 - 0.14 11.5 0.1 0.43 9.9 0.0 1.7 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) PTR2 PF00854.16 CCF34315.1 - 8.5e-22 77.4 1.4 1.2e-21 76.9 1.0 1.3 1 0 0 1 1 1 1 POT family Asp PF00026.18 CCF34316.1 - 2e-64 217.8 8.3 2.3e-64 217.6 5.7 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.1 CCF34316.1 - 1e-05 25.9 1.5 0.034 14.6 0.4 2.8 2 1 0 2 2 2 2 Aspartyl protease TAXi_N PF14543.1 CCF34316.1 - 0.0038 17.1 0.0 0.017 15.0 0.0 2.0 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Methyltransf_23 PF13489.1 CCF34317.1 - 1.4e-21 76.8 0.0 2e-21 76.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF34317.1 - 1.2e-08 34.7 0.0 5e-08 32.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF34317.1 - 7.7e-08 32.9 0.0 1.2e-06 29.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF34317.1 - 1.9e-06 28.2 0.0 2.1e-05 24.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF34317.1 - 3.3e-05 24.2 0.0 6.6e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF34317.1 - 0.00078 19.7 0.0 0.002 18.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 CCF34317.1 - 0.012 15.5 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Atrophin-1 PF03154.10 CCF34317.1 - 0.053 11.6 2.7 0.063 11.4 1.9 1.0 1 0 0 1 1 1 0 Atrophin-1 family Methyltransf_4 PF02390.12 CCF34317.1 - 0.09 11.8 0.0 0.09 11.8 0.0 2.2 2 0 0 2 2 2 0 Putative methyltransferase Phage_integ_N PF09003.5 CCF34317.1 - 0.097 12.3 0.6 3.6 7.3 0.1 2.4 2 0 0 2 2 2 0 Bacteriophage lambda integrase, N-terminal domain MTS PF05175.9 CCF34317.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.15 CCF34317.1 - 0.13 11.3 0.0 0.37 9.8 0.0 1.6 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase VanY PF02557.12 CCF34318.1 - 0.018 14.9 0.1 0.025 14.4 0.0 1.2 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Alpha-amylase PF00128.19 CCF34319.1 - 5e-23 81.9 1.4 3.7e-20 72.5 0.9 2.9 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_transf_5 PF08323.6 CCF34319.1 - 3e-17 62.9 0.4 5e-17 62.2 0.3 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.15 CCF34319.1 - 1.4e-07 31.0 0.0 2.6e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 CCF34319.1 - 5.3e-07 29.8 0.0 1.6e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 Fasciclin PF02469.17 CCF34320.1 - 1.5e-34 118.7 0.0 1.1e-18 67.4 0.0 2.2 2 0 0 2 2 2 2 Fasciclin domain Glyco_hydro_18 PF00704.23 CCF34322.1 - 2.1e-49 168.8 1.3 3.3e-49 168.1 0.9 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.15 CCF34322.1 - 4.4e-05 23.2 0.0 0.23 11.3 0.0 2.8 2 0 0 2 2 2 2 LysM domain Chitin_bind_1 PF00187.14 CCF34322.1 - 0.00042 20.2 2.2 0.00042 20.2 1.5 2.7 2 0 0 2 2 2 1 Chitin recognition protein DnaJ PF00226.26 CCF34323.1 - 0.13 12.0 0.1 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 DnaJ domain Carboxyl_trans PF01039.17 CCF34324.1 - 2.3e-176 586.9 0.0 2.8e-176 586.6 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain Rho_GDI PF02115.12 CCF34324.1 - 0.073 12.4 0.2 0.32 10.3 0.0 2.0 2 0 0 2 2 2 0 RHO protein GDP dissociation inhibitor Sugar_tr PF00083.19 CCF34325.1 - 1.1e-102 344.0 18.6 1.2e-102 343.8 12.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF34325.1 - 1.2e-30 106.4 24.9 3.9e-23 81.7 5.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Acetyltransf_2 PF00797.12 CCF34326.1 - 4.7e-43 147.4 0.0 6.2e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 N-acetyltransferase Transglut_core2 PF13369.1 CCF34326.1 - 0.12 11.8 0.1 0.3 10.5 0.0 1.6 2 0 0 2 2 2 0 Transglutaminase-like superfamily Inhibitor_I9 PF05922.11 CCF34327.1 - 0.00038 20.9 0.0 0.00044 20.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase inhibitor I9 Ank_2 PF12796.2 CCF34328.1 - 1.8e-25 89.0 0.1 6.7e-16 58.4 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 CCF34328.1 - 5.8e-22 76.3 0.3 1.4e-08 34.1 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.1 CCF34328.1 - 9.7e-21 71.7 0.5 5.2e-07 29.2 0.0 4.6 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.1 CCF34328.1 - 1.5e-16 60.0 1.7 2.3e-08 33.9 0.0 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 CCF34328.1 - 6e-16 58.4 1.2 6.5e-10 39.2 0.1 4.3 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Pro_isomerase PF00160.16 CCF34329.1 - 7.9e-46 156.0 0.0 9e-46 155.9 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MFS_1 PF07690.11 CCF34330.1 - 3.7e-31 108.1 31.5 3.7e-31 108.1 21.8 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily PUA PF01472.15 CCF34330.1 - 0.17 11.6 0.1 0.31 10.8 0.0 1.3 1 0 0 1 1 1 0 PUA domain tRNA_int_end_N2 PF12928.2 CCF34331.1 - 3.7e-16 58.3 0.0 6.9e-16 57.4 0.0 1.5 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.9 CCF34331.1 - 0.066 12.7 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 tRNA intron endonuclease, N-terminal domain G6PD_bact PF10786.4 CCF34331.1 - 0.091 12.1 0.5 0.62 9.4 0.1 2.0 2 0 0 2 2 2 0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Ribonuc_red_lgC PF02867.10 CCF34331.1 - 0.15 10.5 0.0 0.2 10.1 0.0 1.1 1 0 0 1 1 1 0 Ribonucleotide reductase, barrel domain His_Phos_2 PF00328.17 CCF34332.1 - 8.3e-25 87.8 0.0 5.9e-24 85.0 0.0 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Acyl-CoA_dh_2 PF08028.6 CCF34335.1 - 6.7e-11 42.5 0.3 9.9e-11 42.0 0.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 CCF34335.1 - 0.0021 18.5 0.1 0.0042 17.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Bac_luciferase PF00296.15 CCF34336.1 - 2.6e-62 210.6 0.2 3.2e-62 210.4 0.1 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase Grp1_Fun34_YaaH PF01184.14 CCF34337.1 - 8.9e-37 126.4 17.5 1.1e-36 126.1 12.2 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF3784 PF12650.2 CCF34337.1 - 1 9.3 8.7 0.36 10.8 1.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) DUF2708 PF10917.3 CCF34337.1 - 5.5 6.8 8.0 13 5.7 0.8 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2708) CDP-OH_P_transf PF01066.16 CCF34337.1 - 7.4 6.9 10.7 0.41 10.9 2.1 2.3 2 0 0 2 2 2 0 CDP-alcohol phosphatidyltransferase Peptidase_M43 PF05572.8 CCF34339.1 - 3.4e-14 52.7 0.0 7.8e-14 51.5 0.0 1.6 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_3 PF13582.1 CCF34339.1 - 4.2e-05 24.0 0.3 7.5e-05 23.2 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 CCF34339.1 - 0.00015 21.7 1.0 0.00059 19.8 0.7 1.9 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.1 CCF34339.1 - 0.00018 21.6 1.9 0.0003 20.9 1.3 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.1 CCF34339.1 - 0.00042 19.9 0.0 0.00057 19.4 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.19 CCF34339.1 - 0.036 13.7 0.3 0.069 12.8 0.2 1.5 1 1 0 1 1 1 0 Matrixin Peptidase_M66 PF10462.4 CCF34339.1 - 0.044 12.6 1.0 0.067 12.0 0.7 1.2 1 0 0 1 1 1 0 Peptidase M66 SnoaL PF07366.7 CCF34340.1 - 2.8e-05 23.6 0.1 0.00011 21.7 0.0 2.0 2 0 0 2 2 2 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.2 CCF34340.1 - 0.0032 17.8 0.3 0.055 13.8 0.0 2.6 1 1 1 2 2 2 1 SnoaL-like domain Lactamase_B_2 PF12706.2 CCF34343.1 - 2.7e-30 105.3 0.0 6.7e-30 104.0 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.1 CCF34343.1 - 1.5e-20 72.4 0.0 3.9e-20 71.0 0.0 1.8 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B PF00753.22 CCF34343.1 - 4.1e-10 39.6 0.0 8.9e-10 38.5 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily DUF1528 PF07515.6 CCF34343.1 - 0.072 13.1 0.3 4 7.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1528) Scs3p PF10261.4 CCF34347.1 - 2.3e-63 213.4 7.8 2.9e-63 213.0 5.4 1.1 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM ATP_transf PF09830.4 CCF34348.1 - 1.2e-15 57.0 0.0 2.3e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 ATP adenylyltransferase Myb_DNA-bind_4 PF13837.1 CCF34349.1 - 0.0022 18.1 0.0 0.0061 16.6 0.0 1.8 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CCF34349.1 - 0.12 12.4 0.0 0.4 10.8 0.0 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain ADH_zinc_N PF00107.21 CCF34351.1 - 6.3e-25 87.2 0.6 1.2e-24 86.3 0.2 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF34351.1 - 1.6e-14 53.6 0.0 1.3e-13 50.5 0.0 2.2 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 CCF34351.1 - 4.5e-10 40.5 0.0 9.4e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Saccharop_dh PF03435.13 CCF34351.1 - 0.085 11.8 0.1 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase ADH_zinc_N PF00107.21 CCF34352.1 - 9.7e-09 34.8 0.0 2.6e-08 33.4 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF34352.1 - 2.2e-05 24.1 0.0 9.5e-05 22.1 0.0 2.1 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Hydrolase PF00702.21 CCF34352.1 - 0.045 14.1 0.2 0.92 9.8 0.2 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF2353 PF09789.4 CCF34353.1 - 0.03 13.5 0.1 0.043 13.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) APG6 PF04111.7 CCF34353.1 - 0.1 11.6 0.2 0.15 11.1 0.1 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 CorA PF01544.13 CCF34354.1 - 5.5e-30 104.3 2.0 6.4e-26 91.0 0.7 2.3 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein 4HBT PF03061.17 CCF34356.1 - 2.9e-15 56.1 0.2 4.5e-15 55.5 0.1 1.3 1 0 0 1 1 1 1 Thioesterase superfamily Zn_clus PF00172.13 CCF34358.1 - 1.5e-08 34.3 8.2 2.8e-08 33.5 5.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF34358.1 - 4e-05 22.3 0.0 0.003 16.2 0.0 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain GATase PF00117.23 CCF34359.1 - 1.5e-10 40.8 0.0 2.8e-10 39.9 0.0 1.4 2 0 0 2 2 2 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 CCF34359.1 - 0.00059 19.3 0.0 0.0024 17.3 0.0 2.0 1 1 0 1 1 1 1 Peptidase C26 FBPase_2 PF06874.6 CCF34359.1 - 0.025 12.6 0.0 0.045 11.7 0.0 1.4 1 0 0 1 1 1 0 Firmicute fructose-1,6-bisphosphatase GATase_3 PF07685.9 CCF34359.1 - 0.046 13.3 0.0 0.073 12.6 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain HTS PF04204.11 CCF34359.1 - 0.13 10.9 0.0 0.16 10.6 0.0 1.3 1 0 0 1 1 1 0 Homoserine O-succinyltransferase AA_permease PF00324.16 CCF34361.1 - 3.6e-17 61.8 1.4 3.6e-17 61.8 1.0 1.7 2 0 0 2 2 2 1 Amino acid permease PNP_UDP_1 PF01048.15 CCF34362.1 - 1.7e-08 33.7 0.7 4.3e-07 29.1 0.4 2.6 2 1 0 2 2 2 1 Phosphorylase superfamily AAA_22 PF13401.1 CCF34362.1 - 3e-08 33.8 0.0 6.3e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 CCF34362.1 - 0.00076 19.1 0.0 0.0019 17.9 0.0 1.6 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 CCF34362.1 - 0.0027 17.7 0.1 0.039 13.9 0.1 2.5 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.17 CCF34362.1 - 0.0074 15.1 0.0 0.043 12.6 0.0 2.0 1 1 0 1 1 1 1 NB-ARC domain AAA_25 PF13481.1 CCF34362.1 - 0.018 14.4 0.0 0.038 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 CCF34362.1 - 0.1 11.9 0.0 0.23 10.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein RRM_1 PF00076.17 CCF34363.1 - 2.3e-12 46.3 0.4 5.1e-08 32.4 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF34363.1 - 3.6e-10 39.6 0.0 3.3e-06 26.9 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF34363.1 - 9.6e-10 38.1 0.0 0.0001 22.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIF_alpha PF05793.7 CCF34363.1 - 0.49 8.7 27.3 0.74 8.1 19.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Sds3 PF08598.6 CCF34364.1 - 2.9e-18 66.1 7.4 2.9e-18 66.1 5.1 2.9 2 1 0 2 2 2 1 Sds3-like Microvir_J PF04726.8 CCF34364.1 - 7.6 6.5 5.8 5.2 7.1 0.3 2.8 2 0 0 2 2 2 0 Microvirus J protein UPF0104 PF03706.8 CCF34365.1 - 0.0052 16.1 0.0 0.0057 15.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0104) Coiled-coil_56 PF09813.4 CCF34365.1 - 0.063 13.2 0.0 0.063 13.2 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 DUF3453 PF11935.3 CCF34366.1 - 1.3e-35 122.9 0.0 1.7e-35 122.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) DDHD PF02862.12 CCF34367.1 - 4.4e-76 255.6 0.0 4.4e-76 255.6 0.0 3.0 3 0 0 3 3 3 1 DDHD domain DUF2305 PF10230.4 CCF34367.1 - 0.07 12.5 0.0 0.18 11.1 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) zf-RING_2 PF13639.1 CCF34368.1 - 0.0012 18.6 1.6 0.0012 18.6 1.1 1.7 2 0 0 2 2 2 1 Ring finger domain Ank_2 PF12796.2 CCF34368.1 - 0.0041 17.4 0.6 0.0095 16.2 0.1 2.0 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) zf-C3HC4_4 PF15227.1 CCF34368.1 - 0.11 12.3 3.2 0.27 11.1 2.2 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 CCF34368.1 - 6.4 6.8 7.7 0.61 10.1 1.8 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF3328 PF11807.3 CCF34369.1 - 2.9e-20 72.8 1.4 1.1e-09 38.3 1.1 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF3328) AMP-binding PF00501.23 CCF34370.1 - 5.5e-65 219.3 2.2 2e-62 210.9 0.2 2.2 1 1 1 2 2 2 2 AMP-binding enzyme Condensation PF00668.15 CCF34370.1 - 5.2e-29 101.0 0.0 1.7e-22 79.6 0.0 2.2 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.20 CCF34370.1 - 1.2e-06 28.6 0.0 6.4e-06 26.3 0.0 2.2 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.1 CCF34370.1 - 0.0041 18.0 0.0 0.027 15.4 0.0 2.5 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain T4SS PF07996.6 CCF34371.1 - 0.015 15.1 0.4 0.015 15.1 0.3 1.0 1 0 0 1 1 1 0 Type IV secretion system proteins Amidase PF01425.16 CCF34372.1 - 3.1e-86 289.9 0.0 3.6e-86 289.7 0.0 1.0 1 0 0 1 1 1 1 Amidase MFS_1 PF07690.11 CCF34373.1 - 1.5e-28 99.5 37.4 1.5e-28 99.5 25.9 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily U1snRNP70_N PF12220.3 CCF34374.1 - 7e-29 99.9 2.5 1.4e-28 99.0 1.8 1.5 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.17 CCF34374.1 - 4.1e-17 61.5 0.1 2.3e-16 59.1 0.0 2.0 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF34374.1 - 1.4e-12 47.3 0.0 3e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF34374.1 - 2.6e-09 36.7 0.0 6.7e-09 35.4 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) L51_S25_CI-B8 PF05047.11 CCF34375.1 - 8.9e-17 60.5 0.0 1.5e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain TIM PF00121.13 CCF34376.1 - 1e-86 289.9 0.5 1.2e-86 289.8 0.3 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase DUF2431 PF10354.4 CCF34377.1 - 1.5e-47 161.6 0.0 6.5e-33 114.0 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF2431) Methyltransf_26 PF13659.1 CCF34377.1 - 0.042 13.8 0.0 0.054 13.5 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain SRI PF08236.6 CCF34378.1 - 2e-22 78.9 4.9 7.8e-22 77.0 3.4 2.1 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.23 CCF34378.1 - 4.4e-22 79.1 0.2 4.4e-22 79.1 0.2 3.7 2 2 0 2 2 2 1 SET domain Med26 PF08711.6 CCF34378.1 - 9.7e-05 21.7 0.2 0.00024 20.5 0.1 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Mito_fiss_reg PF05308.6 CCF34378.1 - 0.0015 17.9 7.2 0.0015 17.9 5.0 2.0 2 0 0 2 2 2 1 Mitochondrial fission regulator WW PF00397.21 CCF34378.1 - 0.011 15.6 0.8 0.024 14.4 0.5 1.7 1 0 0 1 1 1 0 WW domain Ndc1_Nup PF09531.5 CCF34378.1 - 2.5 6.4 4.7 5 5.4 3.3 1.5 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PARP PF00644.15 CCF34379.1 - 5.2e-08 32.5 0.2 0.00011 21.6 0.0 3.6 1 1 2 3 3 3 2 Poly(ADP-ribose) polymerase catalytic domain PTS_2-RNA PF01885.11 CCF34379.1 - 0.066 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 RNA 2'-phosphotransferase, Tpt1 / KptA family Pectate_lyase PF03211.8 CCF34380.1 - 3.2e-52 177.0 0.2 4.5e-52 176.5 0.1 1.1 1 0 0 1 1 1 1 Pectate lyase HET PF06985.6 CCF34381.1 - 7.3e-20 71.5 3.2 1.8e-17 63.7 2.2 2.2 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF4367 PF14285.1 CCF34382.1 - 0.057 12.7 0.3 0.14 11.4 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4367) MaoC_dehydratas PF01575.14 CCF34383.1 - 1.7e-31 108.1 0.0 3.2e-31 107.2 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain adh_short PF00106.20 CCF34383.1 - 3.7e-10 39.9 0.0 7.1e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase MaoC_dehydrat_N PF13452.1 CCF34383.1 - 2.6e-08 33.7 0.0 2.8e-06 27.1 0.0 2.5 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase KR PF08659.5 CCF34383.1 - 0.0057 16.3 0.0 0.0099 15.5 0.0 1.4 1 0 0 1 1 1 1 KR domain SoxE PF06525.6 CCF34383.1 - 0.057 12.6 0.2 4.5 6.4 0.0 2.3 2 0 0 2 2 2 0 Sulfocyanin (SoxE) IBR PF01485.16 CCF34384.1 - 6.7e-07 29.0 5.1 6.7e-07 29.0 3.5 4.2 5 0 0 5 5 5 3 IBR domain adh_short PF00106.20 CCF34385.1 - 3.4e-34 118.1 0.0 6e-34 117.3 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF34385.1 - 2.5e-14 53.6 0.0 3.1e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF34385.1 - 1.6e-13 50.7 0.0 2.3e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.3 CCF34385.1 - 0.00034 20.3 0.1 0.00077 19.2 0.1 1.6 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Polysacc_synt_2 PF02719.10 CCF34385.1 - 0.0083 15.0 0.2 0.019 13.8 0.1 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein IgG_binding_B PF01378.12 CCF34386.1 - 0.079 12.7 0.5 0.14 11.9 0.0 1.7 2 0 0 2 2 2 0 B domain HNH_2 PF13391.1 CCF34387.1 - 4.1e-09 36.1 0.0 8.9e-09 35.0 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease DctQ PF04290.7 CCF34390.1 - 2.7 7.7 10.8 0.64 9.7 4.2 2.2 1 1 1 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component adh_short PF00106.20 CCF34391.1 - 5.4e-31 107.7 0.8 1e-30 106.8 0.6 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF34391.1 - 1.5e-21 77.3 0.0 5.9e-21 75.3 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF34391.1 - 4e-14 52.6 0.1 7.1e-14 51.8 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF34391.1 - 1.3e-05 24.7 0.0 4.6e-05 22.9 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.13 CCF34391.1 - 0.038 13.6 0.1 0.061 12.9 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1776 PF08643.5 CCF34391.1 - 0.089 11.9 0.0 0.092 11.8 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) F420_oxidored PF03807.12 CCF34391.1 - 0.11 12.9 0.2 0.22 11.9 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Polysacc_synt_2 PF02719.10 CCF34391.1 - 0.16 10.8 0.0 0.21 10.4 0.0 1.3 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein DFP PF04127.10 CCF34391.1 - 0.16 11.5 1.0 0.83 9.2 0.7 2.0 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein DUF382 PF04037.8 CCF34392.1 - 6.5e-62 207.0 0.8 2e-61 205.5 0.6 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.11 CCF34392.1 - 9.1e-19 66.5 6.6 1.9e-18 65.5 4.6 1.6 1 0 0 1 1 1 1 PSP VEFS-Box PF09733.4 CCF34393.1 - 1.4e-05 24.7 0.0 2.5e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 VEFS-Box of polycomb protein PHD PF00628.24 CCF34393.1 - 9.6e-05 21.9 4.3 9.6e-05 21.9 3.0 2.0 3 0 0 3 3 3 1 PHD-finger MTHFR_C PF12225.3 CCF34393.1 - 0.08 12.4 3.0 0.2 11.2 2.1 1.6 1 0 0 1 1 1 0 Methylene-tetrahydrofolate reductase C terminal F-box-like PF12937.2 CCF34394.1 - 0.0036 16.9 0.1 0.0095 15.6 0.1 1.7 1 0 0 1 1 1 1 F-box-like Fzo_mitofusin PF04799.8 CCF34395.1 - 0.065 12.6 0.5 0.093 12.1 0.4 1.1 1 0 0 1 1 1 0 fzo-like conserved region Hist_deacetyl PF00850.14 CCF34396.1 - 7.2e-91 304.7 0.1 1e-90 304.2 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Arb2 PF09757.4 CCF34396.1 - 8.1e-38 129.6 0.2 1.4e-37 128.8 0.2 1.4 1 0 0 1 1 1 1 Arb2 domain Ebola_NP PF05505.7 CCF34396.1 - 1.6 6.7 3.7 2.3 6.1 2.6 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein F-box PF00646.28 CCF34397.1 - 0.0004 19.9 0.0 0.001 18.6 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 CCF34397.1 - 0.0087 15.7 0.2 0.12 12.0 0.0 2.5 2 0 0 2 2 2 1 F-box-like Ras PF00071.17 CCF34399.1 - 2.1e-63 212.5 0.2 2.5e-63 212.3 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF34399.1 - 2e-21 76.6 0.1 2.7e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CCF34399.1 - 4e-13 48.9 0.1 5e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 CCF34399.1 - 3e-08 33.6 0.1 4.9e-08 32.9 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CCF34399.1 - 4.7e-05 22.8 0.1 0.00016 21.2 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 CCF34399.1 - 0.0001 21.5 0.1 0.00017 20.8 0.1 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.1 CCF34399.1 - 0.00013 22.1 0.1 0.00033 20.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 CCF34399.1 - 0.0016 18.3 0.1 0.0034 17.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.1 CCF34399.1 - 0.002 17.2 0.1 0.0023 17.0 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 CCF34399.1 - 0.0026 16.9 0.1 0.0062 15.7 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 SpoIIID PF12116.3 CCF34399.1 - 0.0076 16.1 0.1 0.096 12.6 0.0 2.1 2 0 0 2 2 2 1 Stage III sporulation protein D SRPRB PF09439.5 CCF34399.1 - 0.013 14.7 0.0 0.023 13.9 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.1 CCF34399.1 - 0.018 14.6 0.1 0.053 13.1 0.0 1.7 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.22 CCF34399.1 - 0.019 15.2 0.1 0.025 14.8 0.0 1.4 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.1 CCF34399.1 - 0.025 14.5 0.4 0.048 13.6 0.3 1.6 1 1 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.13 CCF34399.1 - 0.091 12.0 0.1 0.23 10.7 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_29 PF13555.1 CCF34399.1 - 0.1 12.1 0.0 0.24 10.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_32 PF13654.1 CCF34399.1 - 0.12 11.0 0.1 0.89 8.1 0.0 1.9 1 1 1 2 2 2 0 AAA domain AAA_5 PF07728.9 CCF34399.1 - 0.13 11.9 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Chromo PF00385.19 CCF34400.1 - 8e-11 41.4 1.3 1.8e-10 40.3 0.9 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DUF3835 PF12927.2 CCF34400.1 - 3 8.8 6.0 0.34 11.8 0.2 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3835) Ndc1_Nup PF09531.5 CCF34400.1 - 7.2 4.8 6.0 9.3 4.5 4.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup LRR_4 PF12799.2 CCF34402.1 - 0.0049 16.4 0.1 8.7 6.0 0.0 3.5 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) AvrD PF05655.6 CCF34402.1 - 0.19 10.6 0.0 0.28 10.0 0.0 1.2 1 0 0 1 1 1 0 Pseudomonas avirulence D protein (AvrD) GST_N_3 PF13417.1 CCF34403.1 - 1e-08 35.2 0.2 1.2e-08 35.0 0.1 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 CCF34403.1 - 1.4e-07 31.3 0.1 1.8e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 CCF34403.1 - 0.00017 21.6 0.0 0.00021 21.3 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Fungal_lectin PF07938.7 CCF34404.1 - 3.8e-05 23.1 8.7 0.00049 19.4 0.9 2.4 1 1 1 2 2 2 2 Fungal fucose-specific lectin DUF2946 PF11162.3 CCF34404.1 - 0.84 9.8 3.6 0.51 10.5 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2946) Peptidase_S10 PF00450.17 CCF34406.1 - 9.5e-93 311.6 0.0 1.1e-92 311.3 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 CCF34406.1 - 1e-05 25.5 0.5 0.00042 20.2 0.3 2.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF34406.1 - 0.0068 16.1 0.0 0.02 14.6 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S10 PF00450.17 CCF34407.1 - 1e-79 268.6 0.0 1.4e-79 268.2 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 CCF34407.1 - 9.5e-12 45.2 0.0 2.4e-11 43.9 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF34407.1 - 7.6e-05 22.5 0.0 0.002 17.8 0.0 2.7 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.5 CCF34407.1 - 0.0044 16.8 0.0 0.75 9.7 0.0 2.9 2 0 0 2 2 2 1 TAP-like protein Aminotran_1_2 PF00155.16 CCF34408.1 - 1.5e-51 175.4 0.0 1.8e-51 175.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Peptidase_S10 PF00450.17 CCF34409.1 - 1.1e-14 54.4 0.0 1.2e-14 54.3 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Methyltransf_24 PF13578.1 CCF34411.1 - 3.5e-19 69.6 0.1 6.6e-19 68.7 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.12 CCF34411.1 - 0.00011 21.3 0.1 0.0007 18.7 0.0 1.9 2 0 0 2 2 2 1 O-methyltransferase Cons_hypoth95 PF03602.10 CCF34411.1 - 0.013 14.8 0.0 0.027 13.8 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein 95 CmcI PF04989.7 CCF34411.1 - 0.076 12.3 0.1 0.33 10.2 0.1 1.8 1 1 0 1 1 1 0 Cephalosporin hydroxylase AMP-binding PF00501.23 CCF34412.1 - 7.2e-36 123.4 0.0 1.2e-35 122.7 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.20 CCF34412.1 - 2.8e-06 27.4 0.0 5.9e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Condensation PF00668.15 CCF34412.1 - 0.00037 19.4 0.1 0.0022 16.9 0.1 1.9 1 1 0 1 1 1 1 Condensation domain AMP-binding_C PF13193.1 CCF34412.1 - 0.0019 19.1 0.4 0.0055 17.6 0.3 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AATase PF07247.7 CCF34412.1 - 0.0075 14.8 0.0 0.59 8.6 0.0 2.1 2 0 0 2 2 2 2 Alcohol acetyltransferase IBR PF01485.16 CCF34413.1 - 0.038 13.8 0.1 0.038 13.8 0.1 1.1 1 0 0 1 1 1 0 IBR domain MOR2-PAG1_C PF14225.1 CCF34414.1 - 5.5e-93 311.5 0.3 5.5e-93 311.5 0.2 1.8 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.1 CCF34414.1 - 2.8e-39 134.5 7.0 7.4e-18 63.5 0.1 3.6 2 1 1 3 3 3 3 Cell morphogenesis central region MOR2-PAG1_N PF14222.1 CCF34414.1 - 1.3e-15 57.1 0.0 2.7e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Cell morphogenesis N-terminal HEAT PF02985.17 CCF34414.1 - 0.11 12.6 3.5 7.8 6.8 0.0 4.7 5 0 0 5 5 5 0 HEAT repeat DIM1 PF02966.11 CCF34415.1 - 2.7e-70 234.0 0.1 3.2e-70 233.8 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin_8 PF13905.1 CCF34415.1 - 0.02 14.9 0.3 0.037 14.1 0.2 1.4 1 1 0 1 1 1 0 Thioredoxin-like DUF2677 PF10838.3 CCF34417.1 - 0.0002 21.0 0.1 0.00061 19.4 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2677) Phosducin PF02114.11 CCF34418.1 - 2.1e-09 36.4 0.1 3.7e-08 32.4 0.1 2.2 1 1 0 1 1 1 1 Phosducin Toxin_24 PF08094.6 CCF34419.1 - 0.074 12.6 1.1 0.074 12.6 0.8 2.1 3 1 0 3 3 3 0 Conotoxin TVIIA/GS family FAD_binding_4 PF01565.18 CCF34420.1 - 1.6e-19 69.7 2.4 2.1e-19 69.3 0.3 2.1 1 1 1 2 2 2 1 FAD binding domain BBE PF08031.7 CCF34420.1 - 2.1e-07 30.7 0.0 4.1e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like ABC_membrane PF00664.18 CCF34421.1 - 1.7e-26 93.2 11.7 3.7e-26 92.1 8.1 1.5 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 CCF34421.1 - 1.5e-24 86.8 0.0 1.4e-23 83.6 0.0 2.2 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.1 CCF34421.1 - 5.6e-11 42.9 0.0 0.0001 22.3 0.0 3.4 2 1 1 3 3 3 2 AAA domain SMC_N PF02463.14 CCF34421.1 - 1.5e-07 30.8 0.8 0.00031 20.0 0.0 2.9 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 CCF34421.1 - 8e-07 29.2 1.3 1.6e-06 28.2 0.9 1.5 1 0 0 1 1 1 1 AAA ATPase domain SbcCD_C PF13558.1 CCF34421.1 - 0.003 17.4 0.3 0.77 9.7 0.0 2.6 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 CCF34421.1 - 0.0041 16.6 0.2 0.011 15.3 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.1 CCF34421.1 - 0.013 15.5 2.7 0.084 13.0 0.3 2.8 2 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 CCF34421.1 - 0.037 13.9 0.4 0.092 12.7 0.1 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase Miro PF08477.8 CCF34421.1 - 0.08 13.4 0.2 0.18 12.3 0.1 1.6 1 0 0 1 1 1 0 Miro-like protein Dynamin_N PF00350.18 CCF34421.1 - 0.095 12.5 0.2 0.18 11.6 0.1 1.5 1 0 0 1 1 1 0 Dynamin family DUF87 PF01935.12 CCF34421.1 - 0.096 12.4 0.3 0.19 11.5 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_10 PF12846.2 CCF34421.1 - 0.31 10.4 4.2 4.8 6.5 0.3 2.9 3 0 0 3 3 3 0 AAA-like domain Mito_fiss_reg PF05308.6 CCF34422.1 - 7.5 5.8 10.2 3.5e+02 0.3 7.1 2.3 1 1 0 1 1 1 0 Mitochondrial fission regulator MFS_1 PF07690.11 CCF34423.1 - 1.1e-23 83.5 23.4 1.3e-23 83.3 16.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MerC PF03203.9 CCF34423.1 - 0.0033 17.7 0.6 0.0033 17.7 0.4 2.4 2 1 0 2 2 2 1 MerC mercury resistance protein WD40 PF00400.27 CCF34425.1 - 3.9e-16 58.2 3.9 8.1e-07 28.6 0.0 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat Nup160 PF11715.3 CCF34425.1 - 0.0037 15.4 0.0 0.023 12.8 0.0 1.9 2 0 0 2 2 2 1 Nucleoporin Nup120/160 Fungal_trans PF04082.13 CCF34426.1 - 9.8e-22 77.0 0.0 2.3e-21 75.8 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF34426.1 - 4.2e-09 36.1 8.4 8.5e-09 35.1 5.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HJURP_C PF12347.3 CCF34427.1 - 0.031 13.8 0.7 0.32 10.5 0.3 2.4 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat AMP-binding PF00501.23 CCF34428.1 - 7.9e-87 291.3 0.0 9.4e-87 291.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF34428.1 - 7.6e-14 52.4 0.0 5e-13 49.7 0.0 2.4 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ECH PF00378.15 CCF34429.1 - 1.1e-37 129.5 0.0 1.8e-37 128.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family HMGL-like PF00682.14 CCF34429.1 - 1e-35 123.5 0.0 2.2e-35 122.4 0.0 1.6 1 1 0 1 1 1 1 HMGL-like ABC_membrane PF00664.18 CCF34430.1 - 5.2e-75 252.4 31.5 8.1e-43 146.7 7.2 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 CCF34430.1 - 1.4e-64 216.4 0.0 2.9e-32 111.8 0.0 3.4 2 1 1 3 3 3 3 ABC transporter SMC_N PF02463.14 CCF34430.1 - 2.2e-13 49.9 7.7 0.00011 21.4 1.3 4.2 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF34430.1 - 4.3e-12 46.5 0.2 0.019 14.9 0.0 4.3 4 0 0 4 4 4 3 AAA domain AAA_16 PF13191.1 CCF34430.1 - 2.3e-08 34.2 1.3 0.0018 18.2 0.0 3.4 3 1 0 3 3 3 2 AAA ATPase domain AAA_17 PF13207.1 CCF34430.1 - 5.5e-08 33.6 0.1 0.0073 17.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 CCF34430.1 - 2e-07 30.4 2.7 0.00018 20.9 0.3 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.4 CCF34430.1 - 2.2e-07 29.8 0.4 0.019 13.5 0.0 3.1 3 0 0 3 3 3 2 Predicted ATPase of the ABC class DUF258 PF03193.11 CCF34430.1 - 7.8e-07 28.4 0.0 0.04 13.0 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 CCF34430.1 - 1e-06 28.9 1.4 0.031 14.4 0.1 3.6 3 1 0 3 3 3 2 AAA domain AAA_30 PF13604.1 CCF34430.1 - 4e-05 23.2 0.3 0.72 9.4 0.0 3.9 4 0 0 4 4 4 2 AAA domain AAA_18 PF13238.1 CCF34430.1 - 7.9e-05 22.9 0.4 0.16 12.2 0.3 2.5 2 0 0 2 2 2 2 AAA domain AAA PF00004.24 CCF34430.1 - 8.8e-05 22.7 2.6 0.57 10.3 0.1 4.5 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 CCF34430.1 - 0.00016 21.1 1.6 1.5 8.1 0.0 3.7 4 0 0 4 4 4 2 AAA domain DUF3987 PF13148.1 CCF34430.1 - 0.00027 19.6 1.3 0.00092 17.8 0.6 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3987) ATP-synt_ab PF00006.20 CCF34430.1 - 0.00038 20.0 0.0 0.52 9.7 0.0 2.7 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA_15 PF13175.1 CCF34430.1 - 0.00043 19.4 0.5 0.73 8.8 0.2 2.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_10 PF12846.2 CCF34430.1 - 0.0013 18.2 1.9 0.12 11.8 0.0 3.7 4 0 0 4 4 4 1 AAA-like domain SbcCD_C PF13558.1 CCF34430.1 - 0.0013 18.5 1.1 0.89 9.5 0.2 3.4 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_5 PF07728.9 CCF34430.1 - 0.0017 18.0 0.3 1.9 8.2 0.0 3.4 4 0 0 4 4 3 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 CCF34430.1 - 0.0023 17.7 0.1 0.67 9.8 0.1 2.8 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 CCF34430.1 - 0.0053 16.6 0.5 8 6.3 0.1 3.4 4 0 0 4 4 3 0 AAA domain Zeta_toxin PF06414.7 CCF34430.1 - 0.0058 15.7 0.0 0.13 11.3 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin MobB PF03205.9 CCF34430.1 - 0.0071 16.0 0.1 2 8.1 0.0 3.2 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_23 PF13476.1 CCF34430.1 - 0.014 15.7 11.0 0.24 11.6 0.4 3.2 3 0 0 3 3 3 0 AAA domain ATP_bind_1 PF03029.12 CCF34430.1 - 0.027 14.0 0.0 0.58 9.6 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein PRK PF00485.13 CCF34430.1 - 0.029 13.9 0.1 9 5.8 0.1 2.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Rad17 PF03215.10 CCF34430.1 - 0.035 12.7 0.4 2.9 6.4 0.0 2.1 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein RNA_helicase PF00910.17 CCF34430.1 - 0.039 14.1 0.2 8.6 6.5 0.0 3.0 3 0 0 3 3 2 0 RNA helicase AAA_28 PF13521.1 CCF34430.1 - 0.039 13.9 0.1 7.8 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 CCF34430.1 - 0.043 13.5 3.9 1.3 8.8 0.0 3.3 3 0 0 3 3 2 0 Part of AAA domain APS_kinase PF01583.15 CCF34430.1 - 0.044 13.4 0.1 6.4 6.4 0.0 2.8 2 0 0 2 2 2 0 Adenylylsulphate kinase IstB_IS21 PF01695.12 CCF34430.1 - 0.095 12.1 2.1 4.2 6.7 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein Dala_Dala_lig_N PF01820.16 CCF34430.1 - 0.14 12.4 0.8 8.3 6.7 0.0 3.1 3 0 0 3 3 3 0 D-ala D-ala ligase N-terminus Glyco_hydro_18 PF00704.23 CCF34432.1 - 3.4e-44 151.7 0.1 3.7e-44 151.5 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_85 PF03644.8 CCF34432.1 - 0.027 13.5 0.0 0.037 13.1 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 85 CoaE PF01121.15 CCF34433.1 - 0.11 11.8 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Dephospho-CoA kinase Prp19_bind PF06991.6 CCF34436.1 - 1.4e-43 149.2 29.3 1.4e-43 149.2 20.3 2.1 1 1 1 2 2 2 1 Splicing factor, Prp19-binding domain Zn_clus PF00172.13 CCF34439.1 - 0.00014 21.7 13.2 0.00024 20.9 9.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tox-URI2 PF15653.1 CCF34440.1 - 0.13 12.5 0.5 0.3 11.3 0.4 1.6 1 0 0 1 1 1 0 URI fold toxin 2 MFS_1 PF07690.11 CCF34441.1 - 1.2e-32 112.9 43.0 3.4e-32 111.5 29.8 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF34441.1 - 1.1e-07 30.4 9.6 1.7e-07 29.8 6.6 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) p450 PF00067.17 CCF34442.1 - 8.2e-57 192.7 0.0 9.5e-57 192.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 CCF34444.1 - 2.5e-47 161.4 0.0 3.3e-34 118.2 0.0 2.5 2 1 0 2 2 2 2 Cytochrome P450 DUF221 PF02714.10 CCF34445.1 - 2.9e-103 345.1 13.3 4e-103 344.6 9.2 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF221 DUF3779 PF12621.3 CCF34445.1 - 1e-28 99.0 0.1 4.3e-26 90.6 0.0 2.4 2 0 0 2 2 2 2 Phosphate metabolism protein DUF4463 PF14703.1 CCF34445.1 - 1.5e-13 51.0 0.1 3.1e-13 50.0 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) RRM_6 PF14259.1 CCF34445.1 - 0.00071 19.5 0.0 0.005 16.7 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CCF34445.1 - 0.0069 16.0 0.0 0.016 14.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF34445.1 - 0.011 15.5 0.0 0.032 14.0 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transferase PF02458.10 CCF34446.1 - 8.7e-11 40.9 0.0 2.4e-10 39.4 0.0 1.7 2 1 0 2 2 2 1 Transferase family TauD PF02668.11 CCF34447.1 - 9.3e-48 163.1 0.2 1.1e-47 162.9 0.1 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family 2OG-FeII_Oxy_3 PF13640.1 CCF34447.1 - 0.00046 20.6 0.8 0.76 10.3 0.0 2.7 1 1 1 2 2 2 2 2OG-Fe(II) oxygenase superfamily Coat_F PF07875.7 CCF34448.1 - 0.04 14.0 0.1 0.18 11.9 0.0 2.0 2 0 0 2 2 2 0 Coat F domain DUF3526 PF12040.3 CCF34448.1 - 0.074 13.1 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3526) Fungal_trans PF04082.13 CCF34449.1 - 2.6e-34 118.2 0.0 4.1e-34 117.6 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain RNHCP PF12647.2 CCF34450.1 - 0.14 12.0 0.8 0.2 11.4 0.6 1.3 1 0 0 1 1 1 0 RNHCP domain GFO_IDH_MocA PF01408.17 CCF34453.1 - 1.4e-21 77.2 0.1 3.9e-21 75.7 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 CCF34453.1 - 7.3e-07 28.9 0.0 1.4e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.11 CCF34453.1 - 2.1e-05 24.8 0.0 4.6e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain AAA_33 PF13671.1 CCF34453.1 - 0.00066 19.5 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Semialdhyde_dh PF01118.19 CCF34453.1 - 0.044 14.0 0.0 0.081 13.2 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Fungal_trans_2 PF11951.3 CCF34454.1 - 3.6e-05 22.5 0.0 5.1e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain GFA PF04828.9 CCF34455.1 - 1.4e-21 76.2 0.4 1.9e-21 75.8 0.3 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme CTP_transf_2 PF01467.21 CCF34456.1 - 9.3e-24 84.2 0.0 1.2e-23 83.9 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase DUF4237 PF14021.1 CCF34456.1 - 0.039 14.2 0.0 0.11 12.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4237) PNK3P PF08645.6 CCF34458.1 - 5.1e-56 188.5 0.1 7.5e-56 187.9 0.0 1.2 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.1 CCF34458.1 - 1.2e-30 106.2 0.0 6.1e-30 103.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 CCF34458.1 - 0.0011 18.1 0.0 0.03 13.4 0.0 2.6 2 1 1 3 3 3 1 Zeta toxin HAD_2 PF13419.1 CCF34458.1 - 0.013 15.7 0.3 8.9 6.4 0.0 3.2 3 1 1 4 4 4 0 Haloacid dehalogenase-like hydrolase Rad17 PF03215.10 CCF34458.1 - 0.053 12.2 0.0 0.1 11.2 0.0 1.4 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein DUF3046 PF11248.3 CCF34458.1 - 0.094 12.7 0.1 22 5.1 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3046) AAA_22 PF13401.1 CCF34458.1 - 0.16 12.0 0.0 0.43 10.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Med18 PF09637.5 CCF34459.1 - 2.8e-30 105.6 0.0 3.3e-30 105.4 0.0 1.0 1 0 0 1 1 1 1 Med18 protein Acetyltransf_1 PF00583.19 CCF34460.1 - 3.3e-09 36.6 0.0 5.5e-09 35.9 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF34460.1 - 3.1e-08 33.6 0.0 6.2e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 CCF34460.1 - 3.6e-05 23.6 0.0 0.0023 17.7 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CCF34460.1 - 0.0012 18.9 0.0 0.0059 16.7 0.0 2.2 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF34460.1 - 0.0019 17.9 0.0 0.0058 16.3 0.0 1.8 1 1 0 1 1 1 1 FR47-like protein Fungal_trans PF04082.13 CCF34461.1 - 6.4e-06 25.2 0.1 1.1e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF34461.1 - 8.6e-06 25.5 15.4 1.9e-05 24.4 10.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain peroxidase PF00141.18 CCF34464.1 - 1.5e-28 99.8 0.0 2.2e-28 99.3 0.0 1.2 1 0 0 1 1 1 1 Peroxidase WD40 PF00400.27 CCF34465.1 - 0.011 15.5 9.6 0.051 13.4 1.5 4.2 5 0 0 5 5 5 0 WD domain, G-beta repeat DUF1687 PF07955.6 CCF34466.1 - 1.6e-18 66.9 0.5 1.3e-17 64.0 0.4 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1687) ArsC PF03960.10 CCF34466.1 - 0.019 15.0 0.0 0.41 10.7 0.0 2.2 1 1 0 1 1 1 0 ArsC family DDHD PF02862.12 CCF34467.1 - 3.5 7.3 5.8 4 7.1 4.0 1.1 1 0 0 1 1 1 0 DDHD domain Ribosomal_L14e PF01929.12 CCF34469.1 - 6.6e-26 90.4 2.1 9e-26 90.0 1.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.24 CCF34469.1 - 0.0021 17.7 0.6 0.0071 16.0 0.0 2.2 3 0 0 3 3 3 1 KOW motif NAC PF01849.13 CCF34470.1 - 1e-25 88.9 0.2 1.8e-24 85.0 0.0 2.4 2 0 0 2 2 2 1 NAC domain UBA PF00627.26 CCF34470.1 - 0.001 18.8 2.1 0.0011 18.7 0.1 2.1 2 0 0 2 2 2 1 UBA/TS-N domain DUF3394 PF11874.3 CCF34470.1 - 0.044 13.3 0.2 0.071 12.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3394) Ribosomal_S13 PF00416.17 CCF34470.1 - 0.42 11.0 2.7 0.63 10.5 0.2 2.2 2 1 0 2 2 2 0 Ribosomal protein S13/S18 Protamine_P2 PF00841.14 CCF34470.1 - 0.91 10.1 4.6 3.5 8.2 0.1 2.3 2 1 0 2 2 2 0 Sperm histone P2 CENP-B_dimeris PF09026.5 CCF34470.1 - 1.9 8.7 9.1 9 6.6 2.3 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Pox_RNA_Pol_19 PF05320.7 CCF34470.1 - 2.2 7.9 9.2 7.9 6.1 0.1 2.2 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit HNF-1_N PF04814.8 CCF34470.1 - 3 7.8 6.4 0.39 10.7 1.4 1.7 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus DUF2417 PF10329.4 CCF34473.1 - 2.4e-69 233.2 8.0 2.9e-69 233.0 5.6 1.0 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Pkinase PF00069.20 CCF34475.1 - 1.8e-39 135.4 0.0 2e-39 135.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF34475.1 - 7.7e-22 77.6 0.0 8.8e-22 77.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF34475.1 - 0.00053 19.0 0.0 0.0009 18.2 0.0 1.3 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 CCF34475.1 - 0.0012 17.8 0.0 0.002 17.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CCF34475.1 - 0.028 14.1 1.9 0.041 13.6 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 CCF34475.1 - 0.2 10.4 0.0 0.73 8.5 0.0 1.7 1 1 1 2 2 2 0 Poxvirus serine/threonine protein kinase p450 PF00067.17 CCF34476.1 - 8.3e-61 205.9 0.0 9.9e-61 205.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ALO PF04030.9 CCF34477.1 - 0.072 12.6 0.0 0.16 11.5 0.0 1.5 1 1 0 1 1 1 0 D-arabinono-1,4-lactone oxidase RabGAP-TBC PF00566.13 CCF34478.1 - 4e-47 160.4 0.0 6.5e-47 159.7 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain EF-hand_6 PF13405.1 CCF34478.1 - 2.7e-07 29.9 0.7 0.0087 15.8 0.2 3.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 CCF34478.1 - 1.2e-05 25.3 0.0 0.00023 21.2 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 CCF34478.1 - 0.00035 19.6 0.3 0.078 12.3 0.2 3.5 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.1 CCF34478.1 - 0.013 14.8 0.9 0.057 12.7 0.6 2.2 1 0 0 1 1 1 0 EF hand Lactamase_B_2 PF12706.2 CCF34479.1 - 0.0047 16.5 0.0 0.0064 16.0 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 CCF34479.1 - 0.051 13.2 0.0 0.092 12.4 0.0 1.5 2 0 0 2 2 2 0 Beta-lactamase superfamily domain RIIa PF02197.12 CCF34480.1 - 0.069 12.5 5.5 7.7 6.0 0.1 3.7 4 0 0 4 4 4 0 Regulatory subunit of type II PKA R-subunit Aa_trans PF01490.13 CCF34481.1 - 1.4e-37 129.2 34.3 1.5e-37 129.0 23.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein SUR7 PF06687.7 CCF34482.1 - 0.065 12.8 2.1 0.069 12.7 1.4 1.1 1 0 0 1 1 1 0 SUR7/PalI family Ank_2 PF12796.2 CCF34483.1 - 4.4e-11 42.9 0.0 8.7e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF34483.1 - 1.7e-09 37.9 0.0 2.5e-08 34.2 0.0 2.7 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.25 CCF34483.1 - 5.4e-09 35.4 0.1 0.00042 19.9 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 CCF34483.1 - 3.2e-07 29.9 0.0 0.019 15.1 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 CCF34483.1 - 5.8e-07 29.5 0.0 0.0026 17.9 0.0 2.7 1 1 2 3 3 3 2 Ankyrin repeats (many copies) NACHT PF05729.7 CCF34483.1 - 0.0021 17.7 0.1 0.0093 15.6 0.1 2.0 2 0 0 2 2 2 1 NACHT domain KAP_NTPase PF07693.9 CCF34483.1 - 0.014 14.4 0.1 0.022 13.7 0.1 1.3 1 0 0 1 1 1 0 KAP family P-loop domain ABC_tran PF00005.22 CCF34485.1 - 3.3e-50 169.9 0.0 4.3e-30 104.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 CCF34485.1 - 1.3e-22 80.5 27.0 1.5e-16 60.6 4.9 3.8 4 1 0 4 4 4 2 ABC transporter transmembrane region SMC_N PF02463.14 CCF34485.1 - 1.5e-10 40.7 0.2 0.00019 20.7 0.0 4.3 3 1 1 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.1 CCF34485.1 - 7.8e-05 22.1 0.0 0.05 13.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 CCF34485.1 - 8.8e-05 22.5 1.3 0.013 15.4 0.1 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.1 CCF34485.1 - 0.00044 19.7 1.0 0.75 9.3 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.1 CCF34485.1 - 0.00091 19.2 0.0 6.7 6.5 0.0 3.6 3 1 0 3 3 3 1 AAA domain T2SE PF00437.15 CCF34485.1 - 0.0013 17.6 0.0 0.6 8.9 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein DUF258 PF03193.11 CCF34485.1 - 0.002 17.3 0.2 2.2 7.4 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_23 PF13476.1 CCF34485.1 - 0.0031 17.8 2.8 0.048 13.9 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.1 CCF34485.1 - 0.0069 15.9 0.1 7 6.1 0.1 3.0 3 0 0 3 3 3 1 AAA domain MMR_HSR1 PF01926.18 CCF34485.1 - 0.0081 16.1 0.1 0.29 11.1 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 CCF34485.1 - 0.0096 16.4 0.1 4.9 7.6 0.0 2.7 2 0 0 2 2 2 1 Miro-like protein AAA_22 PF13401.1 CCF34485.1 - 0.013 15.5 0.7 23 5.1 0.1 3.4 2 1 0 2 2 2 0 AAA domain SbcCD_C PF13558.1 CCF34485.1 - 0.055 13.3 0.0 13 5.7 0.0 3.3 3 0 0 3 3 3 0 Putative exonuclease SbcCD, C subunit IstB_IS21 PF01695.12 CCF34485.1 - 0.11 11.9 0.0 4.7 6.5 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF2075 PF09848.4 CCF34485.1 - 0.16 10.8 0.0 2.3 7.1 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) FtsK_SpoIIIE PF01580.13 CCF34485.1 - 0.18 11.2 0.1 7.4 5.9 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family FAM176 PF14851.1 CCF34485.1 - 0.73 9.5 5.0 0.47 10.1 0.0 2.9 4 0 0 4 4 3 0 FAM176 family DUF87 PF01935.12 CCF34485.1 - 4.7 6.9 10.1 0.83 9.4 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function DUF87 MFS_1 PF07690.11 CCF34486.1 - 7.3e-10 38.0 29.8 3.9e-08 32.3 8.0 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3301 PF11743.3 CCF34486.1 - 0.12 11.9 0.1 0.26 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3301) DUF1049 PF06305.6 CCF34486.1 - 0.19 11.2 4.4 0.56 9.7 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1049) HIG_1_N PF04588.8 CCF34486.1 - 0.52 10.0 5.7 4.7 7.0 0.3 2.6 2 0 0 2 2 2 0 Hypoxia induced protein conserved region GMC_oxred_N PF00732.14 CCF34487.1 - 7.7e-59 199.2 0.0 9.7e-59 198.9 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF34487.1 - 4.9e-34 117.6 0.0 9.2e-34 116.7 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 CCF34487.1 - 3.6e-07 29.3 0.0 0.019 13.8 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 CCF34487.1 - 3e-05 23.1 0.0 0.00055 18.9 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF34487.1 - 0.00028 20.8 0.0 0.00077 19.4 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 CCF34487.1 - 0.0069 15.3 0.1 0.022 13.7 0.0 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.9 CCF34487.1 - 0.0094 15.8 0.0 0.43 10.4 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF34487.1 - 0.05 13.3 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding DAGAT PF03982.8 CCF34487.1 - 0.16 10.5 0.0 0.27 9.9 0.0 1.2 1 0 0 1 1 1 0 Diacylglycerol acyltransferase NmrA PF05368.8 CCF34488.1 - 4.5e-24 84.9 0.0 6e-24 84.5 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF34488.1 - 1.2e-16 61.2 0.2 1.2e-15 58.0 0.1 2.0 1 1 0 1 1 1 1 NADH(P)-binding DapB_N PF01113.15 CCF34488.1 - 0.0072 16.2 0.0 0.02 14.8 0.0 1.8 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NmrA PF05368.8 CCF34489.1 - 0.0094 15.2 0.0 0.0097 15.1 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Peptidase_S8 PF00082.17 CCF34490.1 - 3e-25 88.9 0.0 4.9e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 Subtilase family TPR_12 PF13424.1 CCF34490.1 - 7.1e-06 25.8 0.0 7e-05 22.6 0.0 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 CCF34490.1 - 0.00018 20.9 0.0 0.0018 17.8 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 CCF34490.1 - 0.0016 18.1 0.6 0.016 15.1 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.1 CCF34490.1 - 0.0081 16.0 2.0 0.018 14.9 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 CCF34490.1 - 0.012 15.2 0.1 0.1 12.2 0.0 2.3 1 1 1 2 2 2 0 TPR repeat Apc3 PF12895.2 CCF34490.1 - 0.034 14.2 0.0 0.24 11.5 0.0 2.4 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 GMC_oxred_N PF00732.14 CCF34491.1 - 1.6e-50 171.9 0.0 1.8e-50 171.7 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 CCF34491.1 - 5.6e-08 32.0 1.4 0.00034 19.6 0.2 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 CCF34491.1 - 2.3e-06 26.7 0.2 0.0006 18.8 0.0 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF34491.1 - 0.00029 20.7 1.4 0.00042 20.2 0.3 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 CCF34491.1 - 0.015 14.3 0.2 0.039 13.0 0.1 1.7 2 0 0 2 2 2 0 Thi4 family Pyr_redox_2 PF07992.9 CCF34491.1 - 0.017 15.0 0.1 0.069 13.0 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF34491.1 - 0.035 14.1 0.0 3 7.8 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF34491.1 - 0.048 12.1 0.2 0.072 11.5 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein FAD_binding_3 PF01494.14 CCF34491.1 - 0.091 11.7 0.1 0.15 11.0 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain adh_short PF00106.20 CCF34492.1 - 2.2e-22 79.7 0.9 7.3e-22 78.0 0.6 1.8 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF34492.1 - 3.9e-11 42.9 0.1 5.9e-11 42.3 0.1 1.2 1 0 0 1 1 1 1 KR domain ketoacyl-synt PF00109.21 CCF34493.1 - 1.9e-59 201.2 0.2 2.5e-59 200.8 0.2 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 CCF34493.1 - 9.7e-20 70.5 0.0 4.3e-19 68.5 0.0 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 CCF34493.1 - 0.14 11.0 0.1 0.26 10.2 0.1 1.4 1 0 0 1 1 1 0 Thiolase, N-terminal domain NAD_binding_2 PF03446.10 CCF34494.1 - 9.3e-19 67.8 0.0 1e-18 67.6 0.0 1.0 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.14 CCF34494.1 - 0.0058 15.8 0.1 0.011 14.9 0.0 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 CCF34494.1 - 0.013 15.5 0.0 0.017 15.2 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase MtlR PF05068.7 CCF34494.1 - 0.044 13.2 0.0 0.065 12.6 0.0 1.2 1 0 0 1 1 1 0 Mannitol repressor FUSC PF04632.7 CCF34495.1 - 0.027 12.9 0.0 0.041 12.3 0.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family PP2C PF00481.16 CCF34496.1 - 1.5e-84 283.3 0.0 1.5e-84 283.3 0.0 1.5 2 0 0 2 2 2 1 Protein phosphatase 2C PP2C_2 PF13672.1 CCF34496.1 - 0.00026 20.4 0.0 0.00072 19.0 0.0 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C Sugar_tr PF00083.19 CCF34497.1 - 3.6e-98 329.0 19.2 4.1e-98 328.8 13.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF34497.1 - 7.5e-23 80.8 46.1 4.5e-16 58.5 9.1 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily DUF3671 PF12420.3 CCF34497.1 - 0.38 10.7 1.2 9.4 6.2 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function tRNA-synt_2 PF00152.15 CCF34498.1 - 6.1e-30 104.1 0.0 6.8e-30 103.9 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) Senescence PF06911.7 CCF34499.1 - 0.025 14.2 2.0 0.038 13.6 1.4 1.3 1 0 0 1 1 1 0 Senescence-associated protein p450 PF00067.17 CCF34501.1 - 6.3e-76 255.7 0.0 7.9e-76 255.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BCDHK_Adom3 PF10436.4 CCF34504.1 - 5.6e-46 156.0 0.2 9.2e-46 155.3 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 CCF34504.1 - 6.6e-12 45.1 0.0 9.3e-11 41.4 0.0 2.5 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 CCF34504.1 - 4.3e-05 23.1 0.0 8.7e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 CCF34504.1 - 0.016 14.9 0.0 0.11 12.2 0.0 2.2 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain Septin PF00735.13 CCF34505.1 - 1.4e-115 385.2 0.2 2.2e-115 384.5 0.1 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 CCF34505.1 - 8e-07 29.0 0.0 1.4e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CCF34505.1 - 3.3e-06 26.6 0.3 5.7e-05 22.6 0.1 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 CCF34505.1 - 1.1e-05 24.7 0.0 3e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Miro PF08477.8 CCF34505.1 - 0.0024 18.3 0.1 0.0081 16.6 0.1 1.9 1 0 0 1 1 1 1 Miro-like protein AAA_24 PF13479.1 CCF34505.1 - 0.0034 17.0 0.1 0.0066 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CCF34505.1 - 0.0039 17.3 0.4 0.017 15.2 0.0 2.1 2 1 0 2 2 2 1 AAA domain AIG1 PF04548.11 CCF34505.1 - 0.0059 15.7 0.0 0.013 14.6 0.0 1.5 1 0 0 1 1 1 1 AIG1 family IIGP PF05049.8 CCF34505.1 - 0.0067 15.2 0.0 0.013 14.3 0.0 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) FtsK_SpoIIIE PF01580.13 CCF34505.1 - 0.0086 15.5 0.8 0.015 14.7 0.0 1.8 2 0 0 2 2 2 1 FtsK/SpoIIIE family Pox_A32 PF04665.7 CCF34505.1 - 0.012 14.8 0.1 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein Ras PF00071.17 CCF34505.1 - 0.018 14.4 0.5 0.054 12.8 0.4 1.8 1 1 0 1 1 1 0 Ras family ArgK PF03308.11 CCF34505.1 - 0.035 12.8 2.0 0.94 8.1 0.0 3.0 3 0 0 3 3 3 0 ArgK protein T2SE PF00437.15 CCF34505.1 - 0.035 13.0 0.4 0.11 11.3 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein NACHT PF05729.7 CCF34505.1 - 0.04 13.5 0.0 0.077 12.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.22 CCF34505.1 - 0.044 14.0 0.3 0.17 12.2 0.0 2.0 2 0 0 2 2 2 0 ABC transporter PduV-EutP PF10662.4 CCF34505.1 - 0.064 12.7 0.3 2.7 7.4 0.2 2.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Sigma54_activat PF00158.21 CCF34505.1 - 0.072 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.1 CCF34505.1 - 0.096 12.6 2.2 0.35 10.8 0.0 2.7 2 1 0 2 2 2 0 AAA ATPase domain DUF2968 PF11180.3 CCF34505.1 - 0.098 12.0 7.4 0.26 10.6 5.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) KAP_NTPase PF07693.9 CCF34505.1 - 0.1 11.5 1.8 0.19 10.7 1.2 1.7 1 1 0 1 1 1 0 KAP family P-loop domain Dynamin_N PF00350.18 CCF34505.1 - 0.12 12.2 8.2 0.68 9.7 0.1 3.1 2 1 1 3 3 3 0 Dynamin family RNA_helicase PF00910.17 CCF34505.1 - 0.12 12.5 0.0 0.36 11.0 0.0 1.9 2 0 0 2 2 1 0 RNA helicase Ribosomal_L6e PF01159.14 CCF34505.1 - 0.22 11.7 5.5 3.8 7.7 0.1 3.3 3 0 0 3 3 3 0 Ribosomal protein L6e Atg14 PF10186.4 CCF34505.1 - 0.95 8.3 7.8 2.1 7.2 5.4 1.5 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Myc-LZ PF02344.10 CCF34505.1 - 4.5 6.9 11.6 1.5 8.5 3.2 2.9 2 1 0 2 2 2 0 Myc leucine zipper domain AAA_23 PF13476.1 CCF34505.1 - 9.5 6.4 21.1 2.7e+02 1.7 14.6 2.2 1 1 0 1 1 1 0 AAA domain WD40 PF00400.27 CCF34506.1 - 1.1e-48 161.3 32.7 1.9e-10 40.1 0.0 12.1 12 0 0 12 12 12 8 WD domain, G-beta repeat Utp12 PF04003.7 CCF34506.1 - 6.5e-27 93.6 0.0 1e-26 92.9 0.0 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family eIF2A PF08662.6 CCF34506.1 - 5.8e-06 26.1 4.6 0.052 13.2 0.1 6.2 6 2 1 7 7 7 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.1 CCF34506.1 - 0.00045 19.4 0.3 2.4 7.1 0.0 3.8 3 2 0 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.3 CCF34506.1 - 0.00077 17.7 1.3 2.2 6.3 0.0 3.5 1 1 2 3 3 3 3 Nucleoporin Nup120/160 DUF4243 PF14027.1 CCF34507.1 - 4.4e-90 302.4 1.4 5.9e-90 302.0 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4243) NAP PF00956.13 CCF34509.1 - 9.5e-48 162.4 1.1 9.5e-48 162.4 0.8 1.8 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) Nucleoplasmin PF03066.10 CCF34509.1 - 0.055 12.9 17.8 0.52 9.8 6.3 2.3 2 0 0 2 2 2 0 Nucleoplasmin Voldacs PF03517.8 CCF34509.1 - 0.067 13.0 6.3 0.13 12.1 4.4 1.5 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling Sigma70_ner PF04546.8 CCF34509.1 - 1.8 8.1 19.9 2 7.9 2.0 3.0 3 0 0 3 3 3 0 Sigma-70, non-essential region Sporozoite_P67 PF05642.6 CCF34509.1 - 5.9 4.6 7.6 2.6 5.8 0.3 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen DUF4611 PF15387.1 CCF34509.1 - 7.2 6.8 15.3 2.2 8.4 2.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DUF3328 PF11807.3 CCF34510.1 - 2.3e-36 125.5 2.2 2.9e-36 125.1 1.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Peptidase_S10 PF00450.17 CCF34511.1 - 1.4e-83 281.3 0.0 1.9e-83 280.9 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Sugar_tr PF00083.19 CCF34512.1 - 1.7e-48 165.3 11.6 2.3e-48 164.8 8.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF34512.1 - 8.9e-15 54.2 20.7 2e-14 53.1 14.4 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF34512.1 - 1.3e-06 27.0 6.4 1.3e-06 27.0 4.5 2.0 1 1 0 2 2 2 1 MFS/sugar transport protein Aldolase_II PF00596.16 CCF34513.1 - 1.8e-43 148.3 0.1 2.2e-43 148.0 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain TauD PF02668.11 CCF34514.1 - 5.1e-33 114.8 0.2 8.6e-33 114.0 0.1 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.7 CCF34514.1 - 0.00017 21.9 0.5 0.0026 18.1 0.1 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF971) F-box-like PF12937.2 CCF34515.1 - 5.9e-05 22.6 0.2 0.00013 21.5 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF34515.1 - 0.002 17.7 0.3 0.0045 16.5 0.0 1.8 2 0 0 2 2 2 1 F-box domain Anoctamin PF04547.7 CCF34516.1 - 0.12 11.0 0.0 0.12 11.0 0.0 1.0 1 0 0 1 1 1 0 Calcium-activated chloride channel Glyco_hydro_6 PF01341.12 CCF34518.1 - 1.6e-78 264.1 0.2 1.9e-78 263.9 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 CFEM PF05730.6 CCF34519.1 - 1.8e-09 37.2 8.3 3.1e-09 36.5 5.7 1.4 1 0 0 1 1 1 1 CFEM domain Spc7_N PF15402.1 CCF34519.1 - 0.9 7.4 7.7 1 7.2 5.4 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF605 PF04652.11 CCF34519.1 - 4.4 6.6 24.6 5.2 6.3 17.1 1.0 1 0 0 1 1 1 0 Vta1 like PAT1 PF09770.4 CCF34519.1 - 6.7 4.8 12.1 7.7 4.6 8.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ribosomal_L22 PF00237.14 CCF34520.1 - 7.6e-15 54.7 0.2 2.7e-06 27.2 0.3 2.5 1 1 1 2 2 2 2 Ribosomal protein L22p/L17e YWFCY PF14293.1 CCF34521.1 - 0.077 12.8 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 YWFCY protein Mitochondr_Som1 PF11093.3 CCF34522.1 - 4.4e-07 29.6 0.1 5.4e-07 29.3 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial export protein Som1 BCS1_N PF08740.6 CCF34524.1 - 5.2e-30 104.4 0.3 6.9e-30 104.0 0.2 1.2 1 0 0 1 1 1 1 BCS1 N terminal SH3_9 PF14604.1 CCF34527.1 - 2.4e-08 33.3 0.2 6.7e-08 32.0 0.2 1.8 1 0 0 1 1 1 1 Variant SH3 domain zf-C3HC4 PF00097.20 CCF34527.1 - 4.7e-07 29.3 4.2 4.7e-07 29.3 2.9 5.4 5 2 0 5 5 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF34527.1 - 7.9e-07 28.8 5.0 7.9e-07 28.8 3.4 5.0 4 1 0 4 4 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 CCF34527.1 - 8.2e-06 25.7 4.4 8.2e-06 25.7 3.1 5.7 4 3 1 5 5 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 CCF34527.1 - 2.2e-05 24.1 0.4 2.2e-05 24.1 0.3 3.6 5 0 0 5 5 4 1 zf-RING of BARD1-type protein SH3_1 PF00018.23 CCF34527.1 - 2.8e-05 23.4 0.1 5.9e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain zf-RING_5 PF14634.1 CCF34527.1 - 0.00011 21.8 3.5 0.00011 21.8 2.4 6.0 6 1 1 7 7 5 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 CCF34527.1 - 0.0006 19.4 1.2 0.0015 18.2 0.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 CCF34527.1 - 0.0023 17.7 5.0 0.0023 17.7 3.5 5.7 5 2 1 6 6 6 1 zinc finger of C3HC4-type, RING SH3_2 PF07653.12 CCF34527.1 - 0.017 14.6 0.2 0.057 12.9 0.0 2.0 2 0 0 2 2 2 0 Variant SH3 domain MIP-T3 PF10243.4 CCF34527.1 - 1 7.7 12.0 1.3 7.3 8.3 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 PALP PF00291.20 CCF34528.1 - 1e-60 205.5 0.2 1.2e-60 205.3 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SNF2_N PF00176.18 CCF34530.1 - 3.8e-67 226.2 0.0 4.8e-67 225.8 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 CCF34530.1 - 1.4e-08 34.4 0.1 2.1e-07 30.6 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 CCF34530.1 - 1e-05 25.4 0.0 2e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_34 PF13872.1 CCF34530.1 - 0.0061 15.3 0.0 0.011 14.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 DEAD_2 PF06733.10 CCF34530.1 - 0.012 15.0 0.0 0.04 13.3 0.0 1.8 2 0 0 2 2 2 0 DEAD_2 Oxysterol_BP PF01237.13 CCF34531.1 - 4.3e-10 38.6 0.1 4.7e-10 38.4 0.1 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein Glyco_hydro_88 PF07470.8 CCF34534.1 - 5.7e-30 104.4 0.1 6.4e-30 104.3 0.1 1.1 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Phage_P2_GpU PF06995.6 CCF34534.1 - 0.067 12.5 0.0 0.17 11.3 0.0 1.6 1 0 0 1 1 1 0 Phage P2 GpU Histone PF00125.19 CCF34535.1 - 1.8e-15 56.7 0.1 2.2e-15 56.5 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.12 CCF34535.1 - 0.00012 21.9 0.1 0.00017 21.4 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.1 CCF34535.1 - 0.00012 22.1 0.1 0.00017 21.7 0.0 1.4 1 1 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 CCF34535.1 - 0.00033 20.6 0.1 0.00059 19.8 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 CCF34535.1 - 0.013 15.2 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated CENP-T PF15511.1 CCF34535.1 - 0.022 14.0 0.0 0.022 14.0 0.0 1.0 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Histone PF00125.19 CCF34536.1 - 3.6e-31 107.0 0.4 5.8e-31 106.4 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 CCF34536.1 - 4.1e-06 26.8 0.0 6.2e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 CCF34536.1 - 0.004 17.1 0.3 0.0074 16.3 0.0 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 CCF34536.1 - 0.014 15.1 0.1 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated PRP3 PF08572.5 CCF34538.1 - 1.8e-67 226.9 9.7 3.2e-67 226.1 6.7 1.4 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.7 CCF34538.1 - 1.1e-39 135.0 2.8 1.1e-39 135.0 2.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) BLUF PF04940.7 CCF34538.1 - 0.0053 16.4 0.4 6.4 6.5 0.0 3.1 3 0 0 3 3 3 2 Sensors of blue-light using FAD RNA_pol_Rpb1_5 PF04998.12 CCF34539.1 - 3.6e-84 282.3 0.0 6.9e-84 281.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 CCF34539.1 - 9.8e-63 211.0 0.2 9.8e-63 211.0 0.2 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.7 CCF34539.1 - 3.2e-34 118.7 2.6 7.8e-22 77.9 0.0 2.7 2 1 0 3 3 3 2 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_3 PF04983.13 CCF34539.1 - 3.9e-33 114.4 0.0 1.5e-32 112.4 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 CCF34539.1 - 1.7e-17 63.1 1.2 6.7e-17 61.1 0.0 2.7 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 4 zf-C2H2 PF00096.21 CCF34540.1 - 8.3e-15 54.1 16.3 0.00012 22.2 0.7 3.9 3 1 1 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF34540.1 - 8.5e-12 44.5 14.1 0.00042 20.4 0.3 3.9 4 0 0 4 4 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CCF34540.1 - 1.3e-07 31.5 19.7 3.1e-05 24.0 0.5 4.3 4 1 1 5 5 5 2 Zinc-finger double domain zf-C2H2_jaz PF12171.3 CCF34540.1 - 0.00099 19.1 11.4 0.31 11.2 0.2 4.4 2 1 1 3 3 3 1 Zinc-finger double-stranded RNA-binding RRN7 PF11781.3 CCF34540.1 - 0.0098 15.3 1.9 2.1 7.9 0.0 3.1 3 0 0 3 3 3 1 RNA polymerase I-specific transcription initiation factor Rrn7 zf-C2HC_2 PF13913.1 CCF34540.1 - 0.02 14.5 0.6 0.075 12.7 0.4 2.0 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-met PF12874.2 CCF34540.1 - 0.027 14.6 5.3 4.1 7.7 0.0 4.0 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-BED PF02892.10 CCF34540.1 - 0.046 13.4 9.5 0.075 12.7 2.4 2.6 2 1 0 2 2 2 0 BED zinc finger zf-LYAR PF08790.6 CCF34540.1 - 0.11 12.2 3.0 3.1 7.5 0.1 3.7 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger PyrI_C PF02748.10 CCF34540.1 - 0.11 11.9 0.7 0.2 11.1 0.1 1.7 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-CHCC PF10276.4 CCF34540.1 - 0.21 11.4 0.2 0.21 11.4 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger domain zf-H2C2_5 PF13909.1 CCF34540.1 - 0.54 10.5 8.0 6.4 7.2 0.0 3.5 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.1 CCF34540.1 - 1.1 9.2 10.0 0.41 10.6 1.3 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_2 PF12756.2 CCF34540.1 - 1.7 8.7 7.4 0.89 9.6 2.1 2.4 1 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) p450 PF00067.17 CCF34541.1 - 5e-46 157.1 0.0 7.3e-46 156.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 CCF34542.1 - 1.2e-35 122.9 0.0 1.5e-35 122.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF4407 PF14362.1 CCF34543.1 - 0.0045 15.9 8.4 0.0052 15.7 5.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.7 CCF34543.1 - 0.018 14.7 10.2 0.2 11.4 0.9 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein bZIP_2 PF07716.10 CCF34543.1 - 0.061 13.1 2.3 4.4 7.2 0.3 2.8 2 1 1 3 3 3 0 Basic region leucine zipper HALZ PF02183.13 CCF34543.1 - 0.064 12.9 2.5 1.6 8.5 0.2 2.9 2 0 0 2 2 2 0 Homeobox associated leucine zipper BBP1_C PF15272.1 CCF34543.1 - 0.15 11.6 3.1 0.25 10.8 1.6 1.7 1 1 1 2 2 2 0 Spindle pole body component BBP1, C-terminal Cytochrom_C_2 PF01322.15 CCF34543.1 - 0.21 12.1 6.2 0.79 10.2 1.6 2.1 1 1 1 2 2 2 0 Cytochrome C' Striatin PF08232.7 CCF34543.1 - 0.27 11.5 5.2 0.47 10.7 3.5 1.5 1 1 0 1 1 1 0 Striatin family DegS PF05384.6 CCF34543.1 - 0.41 9.8 3.2 0.57 9.3 2.1 1.3 1 1 0 1 1 1 0 Sensor protein DegS bZIP_1 PF00170.16 CCF34543.1 - 0.5 10.3 4.8 10 6.1 0.2 2.5 2 0 0 2 2 2 0 bZIP transcription factor ERM PF00769.14 CCF34543.1 - 1.3 8.5 10.8 0.17 11.4 1.4 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family OmpH PF03938.9 CCF34543.1 - 7 6.5 14.4 25 4.7 10.0 1.8 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) IncA PF04156.9 CCF34543.1 - 8.2 5.9 8.9 33 3.9 6.2 1.9 1 1 0 1 1 1 0 IncA protein CMS1 PF14617.1 CCF34544.1 - 9.3e-87 290.2 1.5 1e-86 290.1 1.0 1.0 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.24 CCF34544.1 - 1e-06 28.3 0.0 1.2e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF3760 PF12586.3 CCF34546.1 - 0.053 13.3 0.1 0.086 12.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3760) Pro_isomerase PF00160.16 CCF34547.1 - 5.9e-35 120.7 0.0 1e-34 119.9 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.17 CCF34547.1 - 1.4e-15 56.6 0.0 2.7e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF34547.1 - 1.6e-10 40.7 0.0 3.3e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF34547.1 - 5.7e-09 35.6 0.1 1.8e-08 34.1 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ABC_membrane PF00664.18 CCF34548.1 - 1.9e-74 250.5 38.8 1.1e-38 133.2 11.0 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 CCF34548.1 - 2.1e-70 235.3 0.5 5.1e-34 117.5 0.0 3.2 3 1 0 3 3 3 2 ABC transporter SMC_N PF02463.14 CCF34548.1 - 2.1e-14 53.3 0.0 9.4e-05 21.7 0.0 4.2 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF34548.1 - 1.4e-12 48.2 0.0 0.089 12.7 0.0 4.4 4 0 0 4 4 4 4 AAA domain AAA_29 PF13555.1 CCF34548.1 - 2.9e-09 36.3 0.9 0.00059 19.3 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.4 CCF34548.1 - 4.4e-09 35.4 0.3 0.015 13.9 0.0 3.8 4 0 0 4 4 4 2 Predicted ATPase of the ABC class DUF258 PF03193.11 CCF34548.1 - 1.1e-08 34.4 0.0 0.001 18.2 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 CCF34548.1 - 2.6e-07 30.8 0.4 0.024 14.7 0.0 3.8 2 2 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 CCF34548.1 - 2e-06 27.0 0.2 0.034 13.2 0.0 3.5 4 0 0 4 4 3 2 Zeta toxin AAA_16 PF13191.1 CCF34548.1 - 3e-06 27.3 1.6 0.0036 17.3 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.1 CCF34548.1 - 6.1e-06 25.7 0.6 0.094 12.1 0.0 2.7 3 0 0 3 3 2 2 AAA domain AAA_33 PF13671.1 CCF34548.1 - 4.4e-05 23.3 0.0 0.2 11.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 CCF34548.1 - 5.8e-05 23.8 0.0 0.31 11.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.1 CCF34548.1 - 0.00042 19.9 2.0 1.6 8.2 0.0 4.2 5 0 0 5 5 4 1 AAA domain SbcCD_C PF13558.1 CCF34548.1 - 0.00061 19.6 0.9 1 9.3 0.0 3.4 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit G-alpha PF00503.15 CCF34548.1 - 0.0021 16.8 1.1 0.75 8.4 0.0 2.5 3 0 0 3 3 2 2 G-protein alpha subunit AAA_23 PF13476.1 CCF34548.1 - 0.0023 18.2 1.8 1.2 9.3 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_14 PF13173.1 CCF34548.1 - 0.0032 17.3 0.0 11 5.9 0.0 4.1 4 0 0 4 4 4 0 AAA domain MobB PF03205.9 CCF34548.1 - 0.0035 17.0 0.0 2.1 8.0 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B APS_kinase PF01583.15 CCF34548.1 - 0.0038 16.9 0.1 4.5 6.9 0.0 3.1 3 0 0 3 3 3 0 Adenylylsulphate kinase AAA_15 PF13175.1 CCF34548.1 - 0.012 14.6 0.0 0.68 8.9 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain RrnaAD PF00398.15 CCF34548.1 - 0.013 14.5 0.0 0.027 13.5 0.0 1.5 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase AAA_5 PF07728.9 CCF34548.1 - 0.014 15.1 0.7 14 5.4 0.0 3.8 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 CCF34548.1 - 0.014 15.3 0.2 0.7 9.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.8 CCF34548.1 - 0.014 14.2 0.0 3.4 6.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) MMR_HSR1 PF01926.18 CCF34548.1 - 0.015 15.2 0.0 5.4 6.9 0.0 2.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_10 PF12846.2 CCF34548.1 - 0.054 12.9 3.3 8.3 5.7 0.1 3.8 4 0 0 4 4 4 0 AAA-like domain AAA_18 PF13238.1 CCF34548.1 - 0.071 13.4 0.0 16 5.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 CCF34548.1 - 0.073 11.9 0.3 3.2 6.5 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain PRK PF00485.13 CCF34548.1 - 0.081 12.4 0.0 14 5.1 0.0 2.6 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family RNA_helicase PF00910.17 CCF34548.1 - 0.11 12.6 0.0 4.8 7.4 0.0 2.5 2 0 0 2 2 2 0 RNA helicase Miro PF08477.8 CCF34548.1 - 0.13 12.7 0.0 48 4.4 0.0 3.4 3 0 0 3 3 2 0 Miro-like protein DUF87 PF01935.12 CCF34548.1 - 0.13 12.0 0.9 2 8.2 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function DUF87 SRP54 PF00448.17 CCF34548.1 - 0.2 11.0 3.7 8.6 5.7 0.0 2.9 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain Peptidase_M56 PF05569.6 CCF34548.1 - 8.2 5.3 8.3 8.2 5.3 0.5 2.7 3 0 0 3 3 2 0 BlaR1 peptidase M56 Glyco_hydro_43 PF04616.9 CCF34549.1 - 1.5e-14 53.8 0.6 2.3e-14 53.1 0.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.15 CCF34549.1 - 0.017 14.5 0.0 0.041 13.2 0.0 1.6 2 0 0 2 2 2 0 Glycosyl hydrolases family 32 N-terminal domain DUF3186 PF11382.3 CCF34550.1 - 0.013 14.6 0.1 0.013 14.6 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3186) Hemerythrin PF01814.18 CCF34551.1 - 0.011 15.9 0.9 1.6 8.8 0.1 3.3 2 1 0 2 2 2 0 Hemerythrin HHE cation binding domain Apolipoprotein PF01442.13 CCF34551.1 - 0.013 15.0 8.3 0.52 9.7 3.9 3.3 1 1 2 3 3 3 0 Apolipoprotein A1/A4/E domain OHCU_decarbox PF09349.5 CCF34551.1 - 0.14 12.4 1.8 9.4 6.5 0.0 3.0 1 1 2 3 3 3 0 OHCU decarboxylase DUF148 PF02520.12 CCF34551.1 - 0.17 11.7 0.2 0.17 11.7 0.1 3.2 2 1 1 3 3 3 0 Domain of unknown function DUF148 DUF883 PF05957.8 CCF34551.1 - 0.33 11.3 16.8 18 5.8 1.4 5.6 3 1 2 5 5 5 0 Bacterial protein of unknown function (DUF883) Bromodomain PF00439.20 CCF34552.1 - 2.2e-11 43.4 0.0 4.4e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 Bromodomain Utp12 PF04003.7 CCF34554.1 - 8.1e-22 77.2 0.9 2e-21 75.9 0.1 2.0 1 1 1 2 2 2 1 Dip2/Utp12 Family BUD22 PF09073.5 CCF34554.1 - 0.00033 19.8 19.7 0.00033 19.8 13.6 2.2 2 0 0 2 2 2 1 BUD22 Ring_hydroxyl_A PF00848.14 CCF34556.1 - 4.5e-31 108.1 2.6 2.2e-30 105.8 1.8 2.0 1 1 0 1 1 1 1 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.21 CCF34556.1 - 5e-18 64.4 0.0 8.9e-18 63.6 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain CorC_HlyC PF03471.12 CCF34556.1 - 0.066 13.0 0.0 0.22 11.3 0.0 1.8 2 0 0 2 2 2 0 Transporter associated domain MTP18 PF10558.4 CCF34557.1 - 3e-52 176.4 0.5 3.8e-52 176.1 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) DUF2611 PF11022.3 CCF34558.1 - 3.3e-28 97.5 0.3 3.6e-28 97.4 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2611) SGL PF08450.7 CCF34559.1 - 1.6e-12 47.3 0.0 3.2e-12 46.3 0.0 1.5 1 1 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region NHL PF01436.16 CCF34559.1 - 1.7e-05 24.5 1.7 0.1 12.5 0.0 3.6 4 1 0 4 4 4 2 NHL repeat Arylesterase PF01731.15 CCF34559.1 - 0.0019 18.1 0.0 0.0043 17.0 0.0 1.5 1 0 0 1 1 1 1 Arylesterase Glycoamylase PF10091.4 CCF34560.1 - 0.084 11.9 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Putative glucoamylase 2OG-FeII_Oxy_2 PF13532.1 CCF34561.1 - 1.4e-27 96.7 0.0 2.5e-27 96.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Isochorismatase PF00857.15 CCF34561.1 - 1.5e-24 86.8 0.1 5.5e-24 85.0 0.1 1.9 1 1 0 1 1 1 1 Isochorismatase family GST_C_3 PF14497.1 CCF34561.1 - 2.5e-06 27.9 0.1 8.7e-06 26.1 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 CCF34561.1 - 0.00043 20.2 0.0 0.0011 18.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 CCF34561.1 - 0.00078 19.2 0.0 0.0019 18.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain SHMT PF00464.14 CCF34562.1 - 1.4e-195 649.3 0.0 1.6e-195 649.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.16 CCF34562.1 - 9.9e-06 24.8 0.0 1.5e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 CCF34562.1 - 0.003 16.5 0.0 0.0098 14.8 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 CCF34562.1 - 0.0096 14.9 0.0 0.014 14.4 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.14 CCF34562.1 - 0.017 13.8 0.0 0.031 13.0 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class-V adh_short PF00106.20 CCF34563.1 - 1.3e-15 57.6 0.0 2.7e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF34563.1 - 9.4e-08 31.9 0.1 1.7e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF34563.1 - 0.0001 22.1 0.0 0.00022 21.0 0.0 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 CCF34563.1 - 0.00015 21.8 0.6 0.0043 17.0 0.2 2.7 2 1 0 2 2 2 1 NADH(P)-binding ADH_zinc_N PF00107.21 CCF34563.1 - 0.0029 17.1 0.0 0.0072 15.8 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Epimerase PF01370.16 CCF34563.1 - 0.06 12.7 0.0 0.095 12.1 0.0 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF295 PF03478.13 CCF34563.1 - 0.077 12.3 0.0 2.2 7.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF295) Fungal_trans_2 PF11951.3 CCF34564.1 - 1.3e-05 24.0 0.5 1.7e-05 23.6 0.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain FAD_binding_4 PF01565.18 CCF34565.1 - 1.6e-14 53.5 1.9 2.5e-14 52.9 0.8 1.8 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.7 CCF34565.1 - 3.3e-12 46.1 0.3 8.9e-12 44.7 0.2 1.8 1 0 0 1 1 1 1 Berberine and berberine like DUF4287 PF14117.1 CCF34566.1 - 0.024 14.3 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4287) TPR_12 PF13424.1 CCF34567.1 - 0.035 14.0 0.1 17 5.3 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat ThiF PF00899.16 CCF34568.1 - 3e-35 121.0 0.0 5.1e-35 120.2 0.0 1.4 1 0 0 1 1 1 1 ThiF family Saccharop_dh PF03435.13 CCF34568.1 - 1.1e-05 24.6 0.1 1.6e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase AA_kinase PF00696.23 CCF34568.1 - 0.022 14.3 0.0 0.037 13.5 0.0 1.3 1 0 0 1 1 1 0 Amino acid kinase family NAD_binding_7 PF13241.1 CCF34568.1 - 0.026 14.7 0.0 0.078 13.2 0.0 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding Glyco_hydro_17 PF00332.13 CCF34568.1 - 0.028 13.4 0.0 0.044 12.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 17 TrkA_N PF02254.13 CCF34568.1 - 0.034 14.1 0.3 0.14 12.1 0.1 2.2 2 0 0 2 2 2 0 TrkA-N domain MAF_flag10 PF01973.13 CCF34568.1 - 0.057 12.9 0.0 0.52 9.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function DUF115 ApbA PF02558.11 CCF34568.1 - 0.068 12.6 0.2 0.14 11.6 0.1 1.6 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ALO PF04030.9 CCF34569.1 - 8.9e-68 228.6 0.0 1.2e-65 221.6 0.0 2.1 1 1 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.18 CCF34569.1 - 9.6e-07 28.3 0.0 2.1e-05 24.0 0.0 2.3 1 1 0 1 1 1 1 FAD binding domain Pox_A_type_inc PF04508.7 CCF34570.1 - 0.17 11.7 1.2 0.95 9.4 0.0 2.4 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Lipase_GDSL_2 PF13472.1 CCF34571.1 - 1.7e-07 31.5 0.4 3.3e-07 30.5 0.3 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 CCF34571.1 - 4.6e-07 29.9 6.4 1.5e-06 28.2 4.4 1.8 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.1 CCF34571.1 - 0.0095 15.6 0.1 0.79 9.4 0.0 2.2 1 1 0 2 2 2 2 GDSL-like Lipase/Acylhydrolase family F-box-like PF12937.2 CCF34572.1 - 4.3e-06 26.3 0.1 5.8e-06 25.9 0.1 1.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF34572.1 - 3.2e-05 23.4 0.1 5e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 F-box domain F-box-like_2 PF13013.1 CCF34572.1 - 0.0061 16.2 0.0 0.0087 15.7 0.0 1.3 1 0 0 1 1 1 1 F-box-like domain Trp_DMAT PF11991.3 CCF34575.1 - 1.3e-93 314.0 0.0 1.6e-93 313.8 0.0 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Condensation PF00668.15 CCF34576.1 - 1.3e-56 191.7 0.0 5.6e-33 114.0 0.0 2.8 3 0 0 3 3 3 2 Condensation domain AMP-binding PF00501.23 CCF34576.1 - 1.7e-41 142.0 0.0 8.9e-36 123.1 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme PP-binding PF00550.20 CCF34576.1 - 1.7e-26 92.2 0.0 4.3e-12 46.1 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site JmjN PF02375.12 CCF34576.1 - 0.017 14.6 0.1 0.046 13.2 0.1 1.8 1 0 0 1 1 1 0 jmjN domain HNH_2 PF13391.1 CCF34578.1 - 1.8e-09 37.2 0.0 3.9e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease Aminotran_4 PF01063.14 CCF34579.1 - 0.055 12.9 0.0 0.085 12.3 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class IV NACHT PF05729.7 CCF34581.1 - 8.7e-09 35.2 0.0 1.6e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 CCF34581.1 - 5.3e-06 26.5 0.2 1.9e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 CCF34581.1 - 0.00034 20.7 0.0 0.00097 19.2 0.0 1.8 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.12 CCF34581.1 - 0.0035 16.7 0.0 0.0055 16.1 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein APS_kinase PF01583.15 CCF34581.1 - 0.007 16.0 0.0 0.015 14.9 0.0 1.6 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_17 PF13207.1 CCF34581.1 - 0.01 16.6 0.0 0.3 11.9 0.0 2.9 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 CCF34581.1 - 0.013 15.6 0.0 0.03 14.4 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.1 CCF34581.1 - 0.017 14.9 0.0 0.047 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 CCF34581.1 - 0.043 12.6 0.0 0.073 11.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_19 PF13245.1 CCF34581.1 - 0.059 13.1 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain KRAP_IP3R_bind PF14722.1 CCF34581.1 - 0.073 12.6 0.1 9.2 5.8 0.0 2.3 1 1 1 2 2 2 0 Ki-ras-induced actin-interacting protein-IP3R-interacting domain AAA_25 PF13481.1 CCF34581.1 - 0.073 12.4 0.1 0.17 11.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 CCF34581.1 - 0.14 11.6 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.1 CCF34581.1 - 0.16 11.5 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.9 CCF34581.1 - 0.2 10.6 0.3 4.5 6.1 0.1 2.1 1 1 0 2 2 2 0 KAP family P-loop domain DEAD PF00270.24 CCF34582.1 - 6.2e-10 38.8 0.0 1.6e-09 37.4 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF34582.1 - 1.8e-05 24.4 0.1 5.5e-05 22.9 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HHH_5 PF14520.1 CCF34582.1 - 3.9e-05 23.7 0.1 0.00017 21.6 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain BTB PF00651.26 CCF34584.1 - 0.0017 18.3 0.1 0.005 16.8 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain NAD_binding_6 PF08030.7 CCF34586.1 - 2.2e-17 63.4 0.0 3.3e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 CCF34586.1 - 4.4e-09 36.4 11.3 4.4e-09 36.4 7.8 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.16 CCF34586.1 - 1.4e-05 25.5 0.0 0.00064 20.2 0.0 2.5 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_8 PF08022.7 CCF34586.1 - 2.2e-05 24.2 0.0 0.0015 18.4 0.0 2.7 2 1 0 2 2 2 1 FAD-binding domain DUF3328 PF11807.3 CCF34587.1 - 0.083 12.5 0.5 0.11 12.2 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) 6PF2K PF01591.13 CCF34588.1 - 3.4e-50 170.1 0.1 1.5e-49 168.1 0.1 1.9 1 1 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 CCF34588.1 - 5.4e-22 78.5 0.2 8.5e-22 77.9 0.2 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) UCH_1 PF13423.1 CCF34589.1 - 7.2e-81 271.8 0.7 1.5e-80 270.8 0.5 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Methyltransf_22 PF13383.1 CCF34590.1 - 5.4e-26 91.6 0.0 7e-26 91.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_21 PF05050.7 CCF34590.1 - 0.00018 21.4 0.0 0.00026 20.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain p450 PF00067.17 CCF34591.1 - 3.9e-21 75.1 0.0 5e-21 74.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BCS1_N PF08740.6 CCF34592.1 - 5.4e-24 84.8 0.1 8.9e-24 84.1 0.1 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 CCF34592.1 - 1.1e-17 64.4 0.1 1.3e-16 60.9 0.0 2.6 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF34592.1 - 0.00037 20.5 0.7 0.037 14.0 0.0 2.3 1 1 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.1 CCF34592.1 - 0.0045 16.4 0.0 0.0098 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 CCF34592.1 - 0.0049 15.9 0.0 0.0082 15.2 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 CCF34592.1 - 0.0052 17.5 1.5 0.013 16.3 0.2 2.3 2 1 0 2 2 2 1 AAA domain KaiC PF06745.8 CCF34592.1 - 0.044 12.9 0.0 0.086 11.9 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_5 PF07728.9 CCF34592.1 - 0.048 13.3 0.1 0.19 11.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 CCF34592.1 - 0.073 13.2 0.0 0.33 11.0 0.0 2.1 3 0 0 3 3 3 0 AAA domain Elongin_A PF06881.6 CCF34592.1 - 0.25 11.7 1.6 0.36 11.2 0.1 1.9 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A zf-C2H2_4 PF13894.1 CCF34594.1 - 1.2e-07 31.5 16.2 0.0015 18.7 0.1 3.6 2 1 1 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF34594.1 - 5.2e-06 26.4 1.3 0.0056 16.9 0.1 3.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 CCF34594.1 - 0.0046 17.0 10.0 0.65 10.2 0.2 3.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding SerH PF06873.6 CCF34594.1 - 0.078 11.5 5.0 0.11 11.0 3.4 1.2 1 0 0 1 1 1 0 Cell surface immobilisation antigen SerH zf-met PF12874.2 CCF34594.1 - 0.15 12.3 8.1 1.7 8.9 0.2 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 CCF34594.1 - 1.6 8.7 15.4 1.8 8.5 1.2 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Mito_fiss_reg PF05308.6 CCF34596.1 - 0.026 13.9 3.0 0.62 9.3 1.7 2.4 2 0 0 2 2 2 0 Mitochondrial fission regulator YadA_stalk PF05662.9 CCF34596.1 - 0.13 12.0 0.1 0.39 10.5 0.0 1.8 2 0 0 2 2 2 0 Coiled stalk of trimeric autotransporter adhesin Fcf1 PF04900.7 CCF34598.1 - 0.0029 17.6 0.4 0.0062 16.5 0.3 1.6 1 0 0 1 1 1 1 Fcf1 CDC45 PF02724.9 CCF34598.1 - 0.15 10.0 2.6 0.18 9.8 1.8 1.0 1 0 0 1 1 1 0 CDC45-like protein API5 PF05918.6 CCF34598.1 - 2 6.8 6.2 2.2 6.6 4.3 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) DUF726 PF05277.7 CCF34599.1 - 2.3e-126 421.3 0.8 3.3e-126 420.8 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Usp PF00582.21 CCF34600.1 - 1.3e-22 80.5 4.8 1.4e-14 54.4 0.3 2.9 3 0 0 3 3 3 2 Universal stress protein family PTPA PF03095.10 CCF34603.1 - 5.9e-112 373.7 0.0 7e-112 373.4 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein RNase_PH PF01138.16 CCF34604.1 - 8.1e-13 48.8 0.0 1.3e-12 48.1 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 CCF34604.1 - 0.052 13.4 0.1 0.2 11.5 0.0 2.0 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 Adaptin_N PF01602.15 CCF34606.1 - 2.2e-113 379.3 0.7 2.9e-113 378.9 0.5 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.5 CCF34606.1 - 4e-57 192.2 5.7 8.8e-57 191.1 4.0 1.6 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain HEAT_2 PF13646.1 CCF34606.1 - 4e-15 55.8 0.7 2.5e-05 24.4 0.1 5.6 2 1 3 5 5 5 3 HEAT repeats CLASP_N PF12348.3 CCF34606.1 - 0.00035 20.0 3.6 0.0051 16.1 0.2 3.2 3 0 0 3 3 3 1 CLASP N terminal HEAT_PBS PF03130.11 CCF34606.1 - 0.0016 18.6 0.1 1.2 9.7 0.0 4.1 3 0 0 3 3 3 1 PBS lyase HEAT-like repeat Alpha_adaptin_C PF02296.11 CCF34606.1 - 0.065 13.1 0.1 0.33 10.9 0.0 2.3 2 0 0 2 2 2 0 Alpha adaptin AP2, C-terminal domain HEAT PF02985.17 CCF34606.1 - 0.19 11.8 8.1 2 8.7 0.2 4.8 5 0 0 5 5 5 0 HEAT repeat HEAT_EZ PF13513.1 CCF34606.1 - 0.34 11.4 3.4 0.93 10.0 0.7 2.9 2 0 0 2 2 2 0 HEAT-like repeat CDP-OH_P_transf PF01066.16 CCF34607.1 - 5.4e-17 61.9 1.1 5.4e-17 61.9 0.8 2.5 3 0 0 3 3 3 1 CDP-alcohol phosphatidyltransferase DUF3433 PF11915.3 CCF34608.1 - 2.1e-42 143.1 14.1 3.2e-24 84.8 0.6 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) CBS PF00571.23 CCF34609.1 - 1.3e-31 108.0 6.9 6.3e-14 51.4 0.2 4.4 4 0 0 4 4 4 4 CBS domain Acyltransferase PF01553.16 CCF34610.1 - 6.3e-06 25.6 0.0 1.1e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Suc_Fer-like PF06999.7 CCF34611.1 - 2.6e-32 112.6 0.0 4.2e-32 112.0 0.0 1.3 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Drf_GBD PF06371.8 CCF34612.1 - 3.6e-16 59.0 0.9 1.1e-14 54.2 0.6 2.4 1 1 0 1 1 1 1 Diaphanous GTPase-binding Domain DUF3535 PF12054.3 CCF34613.1 - 1.4e-139 465.5 0.3 9.6e-139 462.7 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3535) SNF2_N PF00176.18 CCF34613.1 - 1.7e-73 247.0 0.0 2.4e-73 246.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HEAT PF02985.17 CCF34613.1 - 1.3e-15 55.9 3.4 0.061 13.4 0.0 8.9 8 0 0 8 8 8 4 HEAT repeat Helicase_C PF00271.26 CCF34613.1 - 6.2e-15 54.8 0.0 1.7e-14 53.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Vac14_Fab1_bd PF12755.2 CCF34613.1 - 4.1e-06 27.0 0.2 0.14 12.5 0.0 3.8 2 1 1 3 3 3 2 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.1 CCF34613.1 - 1.7e-05 24.9 11.7 0.064 13.5 0.0 7.5 9 1 1 10 10 10 2 HEAT repeats HEAT_EZ PF13513.1 CCF34613.1 - 0.0014 19.0 9.1 77 3.9 0.0 8.3 9 0 0 9 9 9 0 HEAT-like repeat Fungal_trans_2 PF11951.3 CCF34615.1 - 9.6e-41 139.6 0.1 1.2e-40 139.3 0.1 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain PhyH PF05721.8 CCF34616.1 - 1.1e-18 68.0 0.2 1.4e-18 67.6 0.1 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Brix PF04427.13 CCF34617.1 - 2.7e-52 177.2 0.0 3.9e-52 176.7 0.0 1.2 1 0 0 1 1 1 1 Brix domain DEAD PF00270.24 CCF34618.1 - 8.5e-46 155.5 0.0 1.3e-45 154.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF34618.1 - 1.5e-25 88.8 0.1 3.7e-25 87.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF34618.1 - 0.00039 20.3 0.0 0.0019 18.0 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Kinesin PF00225.18 CCF34619.1 - 4.8e-56 189.8 0.0 7.6e-56 189.2 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain HALZ PF02183.13 CCF34619.1 - 0.7 9.6 4.6 0.23 11.1 0.6 2.1 2 0 0 2 2 2 0 Homeobox associated leucine zipper Bac_rhodopsin PF01036.13 CCF34620.1 - 3.5e-61 206.3 13.3 4.6e-61 205.9 9.2 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein Cytochrom_B561 PF03188.11 CCF34620.1 - 0.6 9.9 9.1 0.53 10.1 0.7 2.3 2 0 0 2 2 2 0 Eukaryotic cytochrome b561 ABC2_membrane_2 PF12679.2 CCF34620.1 - 0.84 8.4 8.5 0.7 8.6 2.4 2.2 2 0 0 2 2 2 0 ABC-2 family transporter protein Arteri_Gl PF00951.13 CCF34620.1 - 2.6 7.5 6.8 0.28 10.7 1.6 1.6 2 0 0 2 2 2 0 Arterivirus GL envelope glycoprotein DUF3784 PF12650.2 CCF34620.1 - 6.5 6.7 8.8 2.2 8.3 0.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) DUF805 PF05656.9 CCF34620.1 - 6.7 6.5 14.2 0.55 10.0 0.9 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF805) Pkinase PF00069.20 CCF34621.1 - 0.064 12.3 0.0 0.078 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Spc97_Spc98 PF04130.8 CCF34622.1 - 1.8e-123 412.7 0.0 2.6e-123 412.2 0.0 1.2 1 0 0 1 1 1 1 Spc97 / Spc98 family DUF3921 PF13060.1 CCF34622.1 - 0.12 12.2 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3921) SAGA-Tad1 PF12767.2 CCF34623.1 - 2.1e-52 178.3 0.0 2.8e-52 177.9 0.0 1.2 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit Mito_carr PF00153.22 CCF34626.1 - 1.4e-24 85.5 2.7 1.6e-11 43.7 0.3 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein Ribonuclease_3 PF00636.21 CCF34628.1 - 9.6e-39 132.3 0.0 8.6e-19 68.0 0.0 2.9 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 CCF34628.1 - 4.8e-24 84.7 0.0 4.9e-11 42.6 0.0 3.6 3 0 0 3 3 3 3 Ribonuclease-III-like Helicase_C PF00271.26 CCF34628.1 - 5.3e-17 61.4 0.0 1.3e-16 60.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 CCF34628.1 - 1.8e-16 60.0 0.0 3.5e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Dicer_dimer PF03368.9 CCF34628.1 - 3.5e-15 55.5 0.0 8.8e-15 54.2 0.0 1.7 1 0 0 1 1 1 1 Dicer dimerisation domain ResIII PF04851.10 CCF34628.1 - 3.3e-08 33.5 0.0 8.3e-08 32.2 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD_2 PF06733.10 CCF34628.1 - 7.9e-05 22.1 0.0 0.0011 18.4 0.0 2.4 2 0 0 2 2 2 1 DEAD_2 SprT-like PF10263.4 CCF34629.1 - 1.6e-14 53.8 0.9 2.5e-14 53.2 0.6 1.4 1 0 0 1 1 1 1 SprT-like family Peptidase_M76 PF09768.4 CCF34629.1 - 0.0097 15.3 0.0 0.02 14.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase M76 family Peptidase_M50 PF02163.17 CCF34629.1 - 0.15 10.9 0.2 0.25 10.2 0.2 1.2 1 0 0 1 1 1 0 Peptidase family M50 SprT-like PF10263.4 CCF34630.1 - 0.0077 15.8 0.1 0.02 14.5 0.1 1.6 1 1 0 1 1 1 1 SprT-like family SprT-like PF10263.4 CCF34631.1 - 0.082 12.5 0.1 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 SprT-like family AAA_12 PF13087.1 CCF34632.1 - 1.5e-26 93.0 0.0 2.9e-26 92.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 CCF34632.1 - 5.1e-22 78.6 0.0 1.4e-21 77.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CCF34632.1 - 1.4e-09 37.5 0.1 2.8e-08 33.3 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 CCF34632.1 - 8.3e-07 28.7 0.0 0.00053 19.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain ResIII PF04851.10 CCF34632.1 - 0.00039 20.2 0.0 0.00078 19.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA PF00004.24 CCF34632.1 - 0.002 18.3 0.0 0.0077 16.4 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DEAD PF00270.24 CCF34632.1 - 0.0024 17.3 0.0 0.0083 15.6 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Viral_helicase1 PF01443.13 CCF34632.1 - 0.0025 17.3 0.3 0.28 10.6 0.0 2.9 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.1 CCF34632.1 - 0.0062 15.9 0.0 0.014 14.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CCF34632.1 - 0.0085 16.2 0.0 0.025 14.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain PIF1 PF05970.9 CCF34632.1 - 0.0099 14.8 0.0 1.5 7.6 0.0 2.2 2 0 0 2 2 2 1 PIF1-like helicase Zeta_toxin PF06414.7 CCF34632.1 - 0.018 14.1 0.0 0.044 12.8 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.1 CCF34632.1 - 0.021 14.7 0.1 0.099 12.6 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain DnaB_C PF03796.10 CCF34632.1 - 0.027 13.3 0.0 0.055 12.3 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_17 PF13207.1 CCF34632.1 - 0.028 15.2 0.0 0.92 10.3 0.0 3.2 2 0 0 2 2 2 0 AAA domain UvrD-helicase PF00580.16 CCF34632.1 - 0.04 13.2 0.2 0.41 9.8 0.0 2.3 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain DUF2075 PF09848.4 CCF34632.1 - 0.046 12.6 0.9 0.065 12.1 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.17 CCF34632.1 - 0.18 11.9 0.0 0.43 10.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Parvo_NS1 PF01057.12 CCF34632.1 - 0.27 10.0 0.0 0.47 9.2 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 efThoc1 PF11957.3 CCF34633.1 - 2.9e-86 289.9 0.4 3.9e-86 289.5 0.3 1.2 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor FA_hydroxylase PF04116.8 CCF34635.1 - 3.8e-07 30.5 13.7 3.8e-07 30.5 9.5 2.6 2 1 1 3 3 3 1 Fatty acid hydroxylase superfamily zf-RING_2 PF13639.1 CCF34637.1 - 4.7e-16 58.3 6.5 4.7e-16 58.3 4.5 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 CCF34637.1 - 7.3e-13 47.9 8.8 3e-10 39.5 1.8 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF34637.1 - 7.3e-09 35.1 13.6 9e-07 28.4 3.5 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 CCF34637.1 - 2.4e-08 33.9 2.8 2.4e-08 33.9 1.9 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 CCF34637.1 - 1.9e-07 30.9 14.7 2.4e-07 30.6 4.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF34637.1 - 8.6e-07 28.5 3.8 8.6e-07 28.5 2.6 2.3 2 0 0 2 2 2 1 zinc-RING finger domain HypA PF01155.14 CCF34637.1 - 0.0012 18.5 0.4 0.0012 18.5 0.3 1.7 2 0 0 2 2 2 1 Hydrogenase expression/synthesis hypA family Prok-RING_4 PF14447.1 CCF34637.1 - 0.0013 18.2 4.0 0.003 17.0 2.8 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-Apc11 PF12861.2 CCF34637.1 - 0.0023 17.7 3.9 0.0023 17.7 2.7 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.1 CCF34637.1 - 0.049 13.5 13.2 0.54 10.1 1.3 3.2 2 1 1 3 3 3 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 CCF34637.1 - 0.052 13.2 3.4 0.24 11.1 0.1 3.1 2 1 1 3 3 3 0 RING-type zinc-finger Prok-RING_1 PF14446.1 CCF34637.1 - 0.056 13.1 11.7 2.3 8.0 0.2 3.0 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 zf-FPG_IleRS PF06827.9 CCF34637.1 - 0.19 11.3 4.8 3.4 7.3 0.1 3.2 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS DZR PF12773.2 CCF34637.1 - 0.23 11.2 3.5 2.4 8.0 0.3 2.4 2 0 0 2 2 2 0 Double zinc ribbon zinc-ribbons_6 PF07191.7 CCF34637.1 - 0.59 9.9 4.4 2.8 7.8 0.4 2.4 2 0 0 2 2 2 0 zinc-ribbons zf-RING_4 PF14570.1 CCF34637.1 - 2.9 7.5 14.2 0.82 9.2 2.7 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Baculo_RING PF05883.6 CCF34637.1 - 3 7.6 4.2 1.1 9.0 0.8 1.7 2 0 0 2 2 2 0 Baculovirus U-box/Ring-like domain PHD PF00628.24 CCF34637.1 - 3.5 7.4 15.0 4.3 7.1 3.9 2.5 2 0 0 2 2 2 0 PHD-finger zf-RING_3 PF14369.1 CCF34637.1 - 4.6 7.3 14.6 0.19 11.7 3.8 2.7 3 0 0 3 3 2 0 zinc-finger PYC_OADA PF02436.13 CCF34639.1 - 5.4e-67 225.0 0.0 8.8e-67 224.3 0.0 1.3 1 0 0 1 1 1 1 Conserved carboxylase domain HMGL-like PF00682.14 CCF34639.1 - 2.6e-20 73.0 0.4 4.4e-20 72.3 0.3 1.4 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.17 CCF34639.1 - 7.9e-19 67.0 4.1 1.4e-18 66.2 1.3 2.4 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.1 CCF34639.1 - 7.6e-12 44.7 2.1 9.2e-07 28.4 0.1 3.6 2 1 1 3 3 3 2 Biotin-lipoyl like HlyD_3 PF13437.1 CCF34639.1 - 2.4e-05 24.6 0.2 0.24 11.7 0.0 3.4 3 0 0 3 3 3 2 HlyD family secretion protein HlyD_2 PF12700.2 CCF34639.1 - 3.7e-05 23.0 0.1 0.045 12.9 0.0 2.2 1 1 1 2 2 2 2 HlyD family secretion protein HlyD PF00529.15 CCF34639.1 - 0.0001 21.7 0.1 0.0059 15.9 0.0 2.5 2 0 0 2 2 2 1 HlyD family secretion protein DUF2118 PF09891.4 CCF34639.1 - 0.0026 17.4 0.2 0.0081 15.8 0.1 1.8 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2118) GCV_H PF01597.14 CCF34639.1 - 0.014 15.0 1.0 0.083 12.5 0.1 2.5 2 1 1 3 3 3 0 Glycine cleavage H-protein PYNP_C PF07831.8 CCF34639.1 - 0.017 14.5 1.3 0.22 10.9 0.0 3.0 3 0 0 3 3 3 0 Pyrimidine nucleoside phosphorylase C-terminal domain NQRA PF05896.6 CCF34639.1 - 0.023 13.8 0.2 0.042 13.0 0.1 1.4 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) RnfC_N PF13375.1 CCF34639.1 - 0.04 13.6 0.5 0.085 12.5 0.3 1.6 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain DUF3572 PF12096.3 CCF34639.1 - 0.11 12.3 0.1 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3572) Proteasome PF00227.21 CCF34640.1 - 1.8e-43 148.0 0.9 9.5e-27 93.5 0.0 3.2 4 0 0 4 4 4 2 Proteasome subunit Proteasome_A_N PF10584.4 CCF34640.1 - 8.1e-12 44.2 0.9 9.9e-12 43.9 0.0 1.6 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DUF4252 PF14060.1 CCF34641.1 - 0.028 13.9 0.4 0.043 13.3 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) CBP4 PF07960.6 CCF34641.1 - 0.24 11.0 7.1 0.11 12.1 2.4 2.2 2 0 0 2 2 2 0 CBP4 UQ_con PF00179.21 CCF34642.1 - 4.8e-32 110.3 0.0 5.8e-32 110.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DUF572 PF04502.8 CCF34643.1 - 1.2e-54 185.7 0.0 1.5e-54 185.4 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) ECM11 PF15463.1 CCF34643.1 - 0.049 13.9 0.8 0.089 13.0 0.5 1.4 1 0 0 1 1 1 0 Extracellular mutant protein 11 MFS_1 PF07690.11 CCF34646.1 - 9.8e-46 156.0 38.5 9.8e-46 156.0 26.7 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF34646.1 - 7.3e-14 51.1 27.3 1.2e-11 43.9 7.8 2.8 2 1 0 2 2 2 2 Sugar (and other) transporter DUF697 PF05128.7 CCF34646.1 - 0.032 13.7 0.8 0.032 13.7 0.5 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF697) FAM220 PF15487.1 CCF34648.1 - 1.4 8.1 4.9 2.9 7.1 3.4 1.5 1 0 0 1 1 1 0 FAM220 family Neisseria_TspB PF05616.8 CCF34648.1 - 2.4 6.4 7.7 5.1 5.3 5.4 1.5 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein HD_3 PF13023.1 CCF34649.1 - 8.5e-47 158.9 0.0 1.1e-46 158.5 0.0 1.1 1 0 0 1 1 1 1 HD domain Abhydrolase_3 PF07859.8 CCF34651.1 - 8.2e-22 77.8 0.0 1.1e-21 77.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF34651.1 - 0.0021 18.0 0.4 0.0028 17.5 0.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF34651.1 - 0.017 14.3 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family HATPase_c PF02518.21 CCF34652.1 - 3.8e-20 71.6 0.0 8e-20 70.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 CCF34652.1 - 2.9e-19 69.1 0.0 7.3e-19 67.8 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.20 CCF34652.1 - 6.3e-14 51.7 0.0 2.1e-13 50.0 0.0 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF PF01590.21 CCF34652.1 - 3.2e-06 27.3 0.0 8.7e-05 22.6 0.0 2.7 2 1 0 2 2 2 1 GAF domain ATP_sub_h PF10775.4 CCF34653.1 - 2.2 8.0 8.4 7.1 6.4 0.1 3.1 1 1 2 3 3 3 0 ATP synthase complex subunit h DUF3328 PF11807.3 CCF34654.1 - 6.8e-49 166.4 1.1 8.5e-49 166.1 0.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF134 PF02001.11 CCF34654.1 - 0.02 14.7 0.0 0.036 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF134 AAA_10 PF12846.2 CCF34655.1 - 9.1e-09 35.1 0.1 2.9e-05 23.6 0.0 2.2 2 0 0 2 2 2 2 AAA-like domain Zot PF05707.7 CCF34655.1 - 9e-05 22.0 0.1 0.00047 19.6 0.0 1.9 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) DUF87 PF01935.12 CCF34655.1 - 0.00079 19.3 0.0 0.32 10.7 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function DUF87 FtsK_SpoIIIE PF01580.13 CCF34655.1 - 0.009 15.4 0.1 0.14 11.5 0.0 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_22 PF13401.1 CCF34655.1 - 0.024 14.7 0.0 8.6 6.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 CCF34655.1 - 0.11 12.6 0.1 0.43 10.7 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 CCF34655.1 - 0.14 11.2 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin DUF1601 PF07671.6 CCF34655.1 - 0.16 11.6 0.9 3.7 7.2 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1601) Ribonuclease_T2 PF00445.13 CCF34656.1 - 2.3e-10 40.4 0.0 3e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family Glyco_hydro_16 PF00722.16 CCF34657.1 - 2.4e-12 46.5 0.0 3.1e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.10 CCF34657.1 - 3.4e-05 22.2 1.2 0.064 11.3 1.1 2.1 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) Peptidase_S8 PF00082.17 CCF34658.1 - 3.8e-44 150.9 0.0 1.3e-43 149.1 0.0 1.9 2 1 0 2 2 2 1 Subtilase family DUF1034 PF06280.7 CCF34658.1 - 2e-14 53.9 0.1 3.3e-14 53.2 0.1 1.4 1 0 0 1 1 1 1 Fn3-like domain (DUF1034) PA PF02225.17 CCF34658.1 - 0.0011 18.6 0.0 0.0034 17.0 0.0 1.9 1 0 0 1 1 1 1 PA domain Acetyltransf_2 PF00797.12 CCF34659.1 - 1.7e-26 93.2 0.0 1.9e-26 93.0 0.0 1.1 1 0 0 1 1 1 1 N-acetyltransferase Transglut_core PF01841.14 CCF34659.1 - 0.14 12.3 0.0 0.18 12.0 0.0 1.3 1 1 0 1 1 1 0 Transglutaminase-like superfamily HSP70 PF00012.15 CCF34660.1 - 4.5e-08 31.4 0.0 3.6e-06 25.2 0.0 2.2 2 0 0 2 2 2 2 Hsp70 protein Rz1 PF06085.6 CCF34660.1 - 0.14 11.5 0.5 0.66 9.4 0.2 2.2 2 0 0 2 2 2 0 Lipoprotein Rz1 precursor MFS_1 PF07690.11 CCF34661.1 - 8.1e-36 123.4 47.7 8.1e-36 123.4 33.0 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF34661.1 - 1.3e-06 27.2 10.5 1.3e-06 27.2 7.3 3.2 2 1 1 3 3 3 2 Sugar (and other) transporter Neurensin PF14927.1 CCF34661.1 - 3.7 6.9 7.2 10 5.4 0.1 3.6 3 1 0 3 3 3 0 Neurensin Mito_carr PF00153.22 CCF34662.1 - 2.6e-73 241.7 0.3 5e-25 87.0 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.27 CCF34662.1 - 6.4e-16 56.3 6.9 4.2e-08 31.9 0.3 5.0 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.1 CCF34662.1 - 6.9e-16 56.6 4.8 1.5e-07 30.6 0.3 5.6 5 0 0 5 5 5 2 EF-hand domain EF-hand_7 PF13499.1 CCF34662.1 - 7.3e-14 51.6 4.4 1.4e-07 31.5 0.7 3.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 CCF34662.1 - 2.2e-13 48.8 6.0 7e-07 28.3 1.1 4.5 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 CCF34662.1 - 2.1e-09 36.8 7.0 0.01 15.3 0.0 5.2 5 1 1 6 6 6 5 EF-hand domain pair EF-hand_9 PF14658.1 CCF34662.1 - 0.0052 16.6 0.1 8.5 6.3 0.0 4.0 4 0 0 4 4 4 1 EF-hand domain PQ-loop PF04193.9 CCF34663.1 - 2.3e-32 110.3 10.6 2.8e-16 58.7 0.7 2.5 2 0 0 2 2 2 2 PQ loop repeat VMA21 PF09446.5 CCF34663.1 - 0.023 14.6 0.2 0.064 13.1 0.1 1.8 1 0 0 1 1 1 0 VMA21-like domain MFS_1 PF07690.11 CCF34666.1 - 6.4e-17 61.3 28.0 3.6e-12 45.6 11.9 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF34666.1 - 0.04 12.4 29.0 0.0084 14.7 2.2 3.8 3 1 1 4 4 4 0 Sugar (and other) transporter Pro-kuma_activ PF09286.6 CCF34668.1 - 1.5e-29 102.8 0.0 3.5e-29 101.6 0.0 1.6 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 CCF34668.1 - 2.2e-09 36.9 0.1 3.4e-09 36.2 0.1 1.2 1 0 0 1 1 1 1 Subtilase family Caps_synth PF05704.7 CCF34670.1 - 1.7e-08 33.9 0.0 2.4e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.10 CCF34670.1 - 2.7e-08 34.1 0.0 4.6e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 CCF34670.1 - 0.045 12.2 0.0 0.22 9.9 0.0 1.8 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain Glyco_hydro_28 PF00295.12 CCF34671.1 - 2.3e-65 220.7 15.7 2.5e-65 220.5 10.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.1 CCF34671.1 - 0.00014 21.6 33.3 0.0013 18.5 23.1 2.1 1 1 0 1 1 1 1 Right handed beta helix region adh_short PF00106.20 CCF34672.1 - 2.4e-15 56.8 0.5 4.8e-15 55.8 0.3 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF34672.1 - 0.00014 21.5 0.0 0.00023 20.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF34672.1 - 0.00024 20.6 0.0 0.00051 19.5 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 CCF34672.1 - 0.0029 17.4 0.0 0.0043 16.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF34673.1 - 1.1e-25 90.5 0.6 1.5e-25 90.0 0.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF34673.1 - 4.6e-12 46.2 0.0 6e-12 45.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF34673.1 - 3e-11 43.3 0.1 4.8e-11 42.6 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF34673.1 - 3.7e-06 26.5 0.0 8.8e-06 25.3 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF34673.1 - 2.4e-05 24.4 0.0 3.3e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding DUF1776 PF08643.5 CCF34673.1 - 0.00063 18.9 0.0 0.00087 18.5 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) ADH_zinc_N PF00107.21 CCF34673.1 - 0.0011 18.4 0.2 0.0027 17.2 0.2 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NmrA PF05368.8 CCF34673.1 - 0.0032 16.7 0.0 0.011 15.0 0.1 1.7 2 0 0 2 2 2 1 NmrA-like family Pkinase PF00069.20 CCF34676.1 - 3.5e-71 239.4 0.1 6.5e-71 238.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF34676.1 - 7.7e-54 182.4 0.1 1.6e-53 181.4 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.23 CCF34676.1 - 4.1e-23 81.5 1.3 1.1e-22 80.2 0.0 2.5 2 0 0 2 2 2 1 P21-Rho-binding domain Kinase-like PF14531.1 CCF34676.1 - 1.2e-08 34.2 0.0 2.1e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like PH_11 PF15413.1 CCF34676.1 - 2.2e-08 34.3 0.5 6.3e-08 32.8 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain APH PF01636.18 CCF34676.1 - 0.0051 16.5 0.1 0.0051 16.5 0.1 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 CCF34676.1 - 0.024 13.5 0.0 0.039 12.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 ZZ PF00569.12 CCF34677.1 - 6.3e-17 60.8 60.9 1.2e-05 24.6 5.8 4.4 4 0 0 4 4 4 4 Zinc finger, ZZ type COPIIcoated_ERV PF07970.7 CCF34678.1 - 4.2e-35 121.3 0.1 6e-35 120.8 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 CCF34678.1 - 8.4e-22 76.9 0.0 1.7e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Colicin_V PF02674.11 CCF34678.1 - 0.065 13.0 0.0 0.17 11.7 0.0 1.6 2 0 0 2 2 2 0 Colicin V production protein Aconitase PF00330.15 CCF34679.1 - 4.6e-153 510.0 0.0 1.8e-152 508.1 0.0 1.8 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 CCF34679.1 - 5.5e-39 133.2 0.0 9e-39 132.5 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.8 CCF34679.1 - 0.0061 15.1 0.0 0.01 14.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF521) Cellulase PF00150.13 CCF34681.1 - 2.1e-19 69.8 3.0 3.4e-19 69.1 2.1 1.3 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Cellulase-like PF12876.2 CCF34681.1 - 1.1e-07 32.2 0.0 2.5e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 Sugar-binding cellulase-like Glyco_hydro_2_C PF02836.12 CCF34681.1 - 0.00015 20.7 0.0 0.00034 19.6 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_42 PF02449.10 CCF34681.1 - 0.001 18.2 0.1 0.003 16.7 0.0 1.8 3 0 0 3 3 3 1 Beta-galactosidase Solute_trans_a PF03619.11 CCF34682.1 - 4.8e-48 163.8 17.7 6.2e-48 163.4 12.2 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Git3_C PF11970.3 CCF34682.1 - 2.2 8.1 6.5 0.41 10.4 1.3 2.3 2 1 1 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term DUF373 PF04123.8 CCF34682.1 - 8.6 5.2 8.6 0.99 8.3 2.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF373) FA_hydroxylase PF04116.8 CCF34684.1 - 1e-15 58.1 24.3 1.2e-15 57.9 14.9 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Kelch_5 PF13854.1 CCF34685.1 - 2.2e-12 46.6 3.9 1.2e-10 41.1 0.2 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.1 CCF34685.1 - 2.8e-06 27.3 13.6 0.0018 18.3 0.1 5.4 5 0 0 5 5 5 2 Galactose oxidase, central domain Herpes_gE PF02480.11 CCF34685.1 - 0.00011 20.6 0.0 0.00016 20.0 0.0 1.2 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E Gly-zipper_Omp PF13488.1 CCF34685.1 - 0.0071 15.9 0.5 0.021 14.4 0.4 1.7 1 0 0 1 1 1 1 Glycine zipper Gly-zipper_YMGG PF13441.1 CCF34685.1 - 0.019 14.4 0.4 0.049 13.1 0.3 1.7 1 0 0 1 1 1 0 YMGG-like Gly-zipper Kelch_1 PF01344.20 CCF34685.1 - 0.033 13.7 2.2 3.3 7.3 0.2 3.9 3 0 0 3 3 3 0 Kelch motif Gly-zipper_OmpA PF13436.1 CCF34685.1 - 0.07 12.7 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Syndecan PF01034.15 CCF34685.1 - 0.16 11.6 0.1 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain Adeno_E3_CR2 PF02439.10 CCF34685.1 - 0.2 11.2 0.9 0.36 10.4 0.6 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 SKG6 PF08693.5 CCF34685.1 - 0.37 10.1 4.2 0.75 9.1 2.9 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Kelch_6 PF13964.1 CCF34685.1 - 4 7.7 12.6 1.8 8.8 0.2 5.1 5 1 0 5 5 5 0 Kelch motif Asp PF00026.18 CCF34686.1 - 6e-51 173.5 0.0 7.6e-51 173.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CCF34686.1 - 1.6e-07 31.4 0.1 2.9e-07 30.5 0.1 1.5 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 CCF34686.1 - 0.014 15.8 0.2 12 6.4 0.0 3.1 2 1 0 2 2 2 0 Aspartyl protease Glyco_hydr_30_2 PF14587.1 CCF34687.1 - 2.4e-17 62.9 0.1 1.1e-16 60.8 0.0 1.9 1 1 0 1 1 1 1 O-Glycosyl hydrolase family 30 Glyco_hydro_30 PF02055.11 CCF34687.1 - 6.1e-16 57.6 1.6 6.6e-10 37.8 0.6 2.5 2 1 0 2 2 2 2 O-Glycosyl hydrolase family 30 APG17 PF04108.7 CCF34688.1 - 0.0008 18.3 5.8 0.0008 18.3 4.0 4.4 3 1 1 4 4 4 2 Autophagy protein Apg17 Spc7 PF08317.6 CCF34688.1 - 1.7 7.1 36.4 0.16 10.6 9.6 4.6 4 1 0 4 4 4 0 Spc7 kinetochore protein DUF1136 PF06582.7 CCF34688.1 - 3.1 7.5 11.2 0.41 10.3 0.3 4.0 3 0 0 3 3 3 0 Repeat of unknown function (DUF1136) CENP-H PF05837.7 CCF34689.1 - 2.6e-27 95.0 4.7 6.1e-26 90.6 0.3 2.5 2 1 0 2 2 2 2 Centromere protein H (CENP-H) TMF_TATA_bd PF12325.3 CCF34689.1 - 0.0078 15.9 1.0 0.0078 15.9 0.7 1.9 2 1 0 2 2 2 1 TATA element modulatory factor 1 TATA binding DASH_Dad3 PF08656.5 CCF34689.1 - 0.066 12.9 0.2 0.3 10.8 0.0 2.1 2 0 0 2 2 2 0 DASH complex subunit Dad3 F-box-like_2 PF13013.1 CCF34691.1 - 0.079 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 F-box-like domain CBM_1 PF00734.13 CCF34692.1 - 8.6e-12 44.5 9.7 8.6e-12 44.5 6.7 2.4 2 0 0 2 2 2 1 Fungal cellulose binding domain Yeast-kill-tox PF09207.6 CCF34692.1 - 0.048 14.0 1.9 0.048 14.0 1.3 1.8 2 1 0 2 2 2 0 Yeast killer toxin Glyco_hydro_6 PF01341.12 CCF34692.1 - 0.14 11.6 0.1 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 6 Adap_comp_sub PF00928.16 CCF34693.1 - 2.7e-84 282.3 0.0 3.5e-84 282.0 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 CCF34693.1 - 6.8e-05 22.6 0.2 0.00012 21.7 0.1 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF1081 PF06448.6 CCF34693.1 - 0.02 14.7 0.1 0.044 13.6 0.1 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1081) DUF647 PF04884.9 CCF34695.1 - 2.9e-24 85.6 0.2 3.3e-24 85.4 0.1 1.0 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis DUF2730 PF10805.3 CCF34695.1 - 0.07 12.8 0.0 0.092 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) MsyB PF13984.1 CCF34696.1 - 0.12 12.3 0.0 0.25 11.4 0.0 1.5 1 1 0 1 1 1 0 MsyB protein Rap1_C PF11626.3 CCF34697.1 - 1.4e-29 101.8 1.5 1.7e-29 101.5 0.2 1.9 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_2 PF08914.6 CCF34697.1 - 1.3e-13 50.5 4.2 2.3e-10 40.0 0.1 3.3 3 0 0 3 3 3 2 Rap1 Myb domain Rap1-DNA-bind PF09197.5 CCF34697.1 - 3.8e-08 33.8 1.4 8.6e-05 23.0 0.0 2.9 2 0 0 2 2 2 2 Rap1, DNA-binding ARID PF01388.16 CCF34697.1 - 7.7e-05 22.4 0.0 0.00018 21.3 0.0 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain zf-DHHC PF01529.15 CCF34698.1 - 1.1e-33 116.0 1.6 2.6e-33 114.8 1.1 1.6 1 0 0 1 1 1 1 DHHC palmitoyltransferase AHSA1 PF08327.6 CCF34699.1 - 9.8e-18 64.4 0.4 1.1e-17 64.2 0.3 1.0 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Sugar_tr PF00083.19 CCF34700.1 - 2.9e-106 355.7 24.0 1e-103 347.3 16.6 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF34700.1 - 1.9e-21 76.2 30.2 1.9e-21 76.2 20.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4410 PF14366.1 CCF34700.1 - 0.026 14.2 0.0 0.059 13.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4410) DUF1269 PF06897.7 CCF34700.1 - 5.4 7.0 7.4 8.1 6.5 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) ADH_zinc_N PF00107.21 CCF34701.1 - 5.6e-13 48.5 0.1 1e-12 47.7 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF34701.1 - 4.8e-09 35.9 0.1 5.5e-08 32.5 0.0 2.4 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain PS-DH PF14765.1 CCF34702.1 - 8.2e-59 199.1 0.1 2e-58 197.8 0.0 1.7 2 0 0 2 2 2 1 Polyketide synthase dehydratase ketoacyl-synt PF00109.21 CCF34702.1 - 6.3e-58 196.2 0.0 1.5e-57 194.9 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 CCF34702.1 - 7.9e-56 189.6 0.0 1.4e-55 188.9 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.17 CCF34702.1 - 1.2e-32 112.2 0.0 4.8e-32 110.3 0.0 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 CCF34702.1 - 0.0021 17.1 0.2 0.0041 16.1 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 CCF34702.1 - 0.041 13.5 1.4 0.1 12.2 1.0 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III UPRTase PF14681.1 CCF34703.1 - 1.3e-73 246.6 0.0 1.5e-73 246.4 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 CCF34703.1 - 7e-07 29.0 0.0 1.7e-06 27.7 0.0 1.6 1 1 0 1 1 1 1 Phosphoribosyl transferase domain P5CR_dimer PF14748.1 CCF34703.1 - 0.024 14.6 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 Pyrroline-5-carboxylate reductase dimerisation TMP-TENI PF02581.12 CCF34703.1 - 0.049 12.7 0.7 0.42 9.7 0.1 2.3 2 1 0 2 2 2 0 Thiamine monophosphate synthase/TENI DNA_ligase_A_M PF01068.16 CCF34704.1 - 1e-42 145.8 0.0 2.3e-42 144.6 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 CCF34704.1 - 1.8e-35 122.3 0.0 3.4e-35 121.4 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 CCF34704.1 - 1.9e-15 57.0 0.3 8.6e-15 54.9 0.0 2.4 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region BRCT PF00533.21 CCF34704.1 - 1.2e-11 44.6 0.0 1.3e-07 31.6 0.0 2.5 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain mRNA_cap_enzyme PF01331.14 CCF34704.1 - 0.069 12.8 0.2 0.94 9.1 0.0 2.9 3 1 0 3 3 3 0 mRNA capping enzyme, catalytic domain DNA_ligase_IV PF11411.3 CCF34704.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 DNA ligase IV VSP PF03302.8 CCF34705.1 - 0.036 12.6 0.2 0.047 12.3 0.2 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein Aa_trans PF01490.13 CCF34706.1 - 1.2e-16 60.2 3.0 1.4e-16 59.9 2.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Clc-like PF07062.7 CCF34706.1 - 0.085 12.1 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Clc-like KH_1 PF00013.24 CCF34707.1 - 0.0012 18.4 0.0 0.0026 17.3 0.0 1.5 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 CCF34707.1 - 0.053 13.2 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 KH domain ADH_zinc_N PF00107.21 CCF34709.1 - 5.1e-23 81.0 0.2 7.7e-23 80.4 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF34709.1 - 1.8e-09 38.5 0.5 9.6e-09 36.2 0.1 2.1 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF34709.1 - 8.6e-05 22.2 0.0 0.00019 21.1 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Rhodanese PF00581.15 CCF34711.1 - 4.8e-08 33.3 0.0 1.4e-07 31.8 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain Homeobox PF00046.24 CCF34711.1 - 1.1e-06 28.1 0.2 3.3e-06 26.6 0.1 1.7 1 0 0 1 1 1 1 Homeobox domain PIG-X PF08320.7 CCF34712.1 - 9.3e-65 217.7 0.0 1.4e-64 217.1 0.0 1.3 1 0 0 1 1 1 1 PIG-X / PBN1 TPR_11 PF13414.1 CCF34714.1 - 1.2e-20 72.8 3.7 2.2e-06 27.2 0.1 4.5 4 0 0 4 4 4 4 TPR repeat TPR_1 PF00515.23 CCF34714.1 - 2.8e-17 61.5 4.9 7.5e-05 22.1 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.12 CCF34714.1 - 3.5e-15 54.6 3.0 0.0076 16.0 0.0 5.9 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_8 PF13181.1 CCF34714.1 - 1.9e-12 46.0 1.2 0.00086 18.9 0.0 5.3 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 CCF34714.1 - 2.3e-10 39.8 1.3 0.0058 16.7 0.0 4.9 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 CCF34714.1 - 4.5e-10 39.2 5.7 0.0066 16.9 0.0 5.0 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 CCF34714.1 - 5.1e-10 39.7 1.1 0.017 15.7 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 CCF34714.1 - 2.7e-09 36.8 4.5 1.5e-07 31.2 0.2 4.1 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 CCF34714.1 - 2.1e-07 30.1 1.4 0.0088 15.7 0.0 4.2 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_10 PF13374.1 CCF34714.1 - 1.6e-06 27.8 2.2 0.3 11.0 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 CCF34714.1 - 0.0044 17.3 2.1 1.6 9.1 0.2 3.0 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.1 CCF34714.1 - 0.01 15.6 0.1 0.27 11.1 0.0 3.2 3 1 2 5 5 4 0 Tetratricopeptide repeat TPR_5 PF12688.2 CCF34714.1 - 0.016 15.2 0.4 0.39 10.7 0.0 2.9 3 0 0 3 3 3 0 Tetratrico peptide repeat Glyco_transf_41 PF13844.1 CCF34714.1 - 0.024 12.5 0.1 0.032 12.2 0.1 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 TPR_15 PF13429.1 CCF34714.1 - 0.058 12.4 0.1 1 8.3 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 CCF34714.1 - 1.2 9.7 9.7 20 5.9 0.3 4.7 5 1 0 5 5 4 0 Tetratricopeptide repeat Ribosomal_L11_N PF03946.9 CCF34715.1 - 3.7e-17 61.5 0.0 6.6e-17 60.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 CCF34715.1 - 6.7e-12 45.3 0.2 1.1e-11 44.6 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Mcp5_PH PF12814.2 CCF34717.1 - 1.3e-41 141.3 0.0 2.3e-41 140.5 0.0 1.4 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology IncA PF04156.9 CCF34717.1 - 0.36 10.4 40.2 3.3 7.2 11.5 4.1 3 1 1 4 4 4 0 IncA protein Peptidase_C6 PF00851.13 CCF34717.1 - 9.2 4.7 8.5 15 4.0 5.9 1.2 1 0 0 1 1 1 0 Helper component proteinase zf-C3HC4_3 PF13920.1 CCF34718.1 - 2.6e-08 33.4 4.6 4.1e-08 32.7 3.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CCF34718.1 - 4.6e-08 32.9 10.2 8e-08 32.1 7.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH PF00642.19 CCF34718.1 - 4.9e-07 29.2 2.3 9e-07 28.4 1.6 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4 PF00097.20 CCF34718.1 - 8.6e-07 28.5 9.8 1.5e-06 27.7 6.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF34718.1 - 9.6e-07 28.4 7.6 1.6e-06 27.7 5.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 CCF34718.1 - 1.8e-05 24.4 6.7 3e-05 23.7 4.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.1 CCF34718.1 - 0.0044 16.7 3.9 0.011 15.4 2.7 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 CCF34718.1 - 0.056 13.3 8.7 0.13 12.1 6.0 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Harakiri PF15196.1 CCF34718.1 - 0.093 12.9 1.2 0.24 11.6 0.9 1.7 1 0 0 1 1 1 0 Activator of apoptosis harakiri Cript PF10235.4 CCF34718.1 - 1.3 9.3 6.1 0.21 11.9 0.9 2.2 3 0 0 3 3 3 0 Microtubule-associated protein CRIPT zf-rbx1 PF12678.2 CCF34718.1 - 1.6 8.8 5.1 3.8 7.6 3.6 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger MARVEL PF01284.18 CCF34719.1 - 4.2e-07 29.8 13.9 7e-07 29.1 9.6 1.3 1 1 0 1 1 1 1 Membrane-associating domain MT0933_antitox PF14013.1 CCF34720.1 - 0.3 11.2 4.9 0.29 11.2 2.8 1.7 1 1 0 1 1 1 0 MT0933-like antitoxin protein Microtub_assoc PF07989.6 CCF34722.1 - 7.8e-18 64.0 4.0 1.3e-17 63.3 2.7 1.4 1 0 0 1 1 1 1 Microtubule associated Hydrolase_6 PF13344.1 CCF34723.1 - 6.5e-25 86.9 0.0 1.3e-24 86.0 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CCF34723.1 - 3.5e-16 58.6 0.0 1.7e-15 56.4 0.0 2.1 2 0 0 2 2 2 1 HAD-hyrolase-like HAD_2 PF13419.1 CCF34723.1 - 1.6e-05 25.2 0.1 0.013 15.7 0.0 3.8 2 2 1 3 3 3 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CCF34723.1 - 0.0014 19.0 0.0 0.65 10.3 0.0 3.3 2 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase SCO1-SenC PF02630.9 CCF34724.1 - 4.9e-44 150.0 0.1 7.5e-42 142.8 0.0 2.1 1 1 0 1 1 1 1 SCO1/SenC PHD PF00628.24 CCF34725.1 - 2.5e-12 46.2 6.1 6.8e-12 44.8 4.2 1.8 1 0 0 1 1 1 1 PHD-finger PTN_MK_N PF05196.8 CCF34725.1 - 0.12 12.3 6.6 1.4 8.9 0.9 2.7 2 0 0 2 2 2 0 PTN/MK heparin-binding protein family, N-terminal domain zf-RING_2 PF13639.1 CCF34725.1 - 2.2 8.1 5.9 4.8 7.1 4.1 1.6 1 0 0 1 1 1 0 Ring finger domain DUF3129 PF11327.3 CCF34727.1 - 2.2e-69 232.9 16.4 1.7e-68 230.0 11.4 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3129) PI-PLC-X PF00388.14 CCF34728.1 - 0.021 14.2 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain DUF3640 PF12342.3 CCF34728.1 - 9.2 5.8 6.5 26 4.4 0.5 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3640) APC8 PF04049.8 CCF34729.1 - 1.4e-36 125.3 1.7 2.7e-36 124.4 0.1 2.2 2 0 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.23 CCF34729.1 - 7.7e-22 75.9 5.0 0.00068 19.1 0.0 8.2 8 1 1 9 9 8 4 Tetratricopeptide repeat TPR_11 PF13414.1 CCF34729.1 - 7.4e-21 73.5 8.4 2.5e-08 33.4 0.6 6.9 4 1 3 7 7 7 5 TPR repeat TPR_2 PF07719.12 CCF34729.1 - 2.7e-16 58.1 18.3 0.095 12.6 0.0 9.3 9 1 1 10 10 9 5 Tetratricopeptide repeat TPR_8 PF13181.1 CCF34729.1 - 2.1e-15 55.2 9.2 0.00067 19.2 0.0 7.1 6 2 2 8 8 7 3 Tetratricopeptide repeat TPR_12 PF13424.1 CCF34729.1 - 3.8e-12 45.9 11.7 0.0003 20.6 0.3 6.1 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.1 CCF34729.1 - 1e-10 41.2 14.5 0.0058 17.1 0.1 8.6 8 1 1 9 9 8 1 Tetratricopeptide repeat TPR_16 PF13432.1 CCF34729.1 - 3.4e-10 40.3 12.1 2e-05 25.0 0.1 7.5 8 1 0 8 8 8 1 Tetratricopeptide repeat Apc3 PF12895.2 CCF34729.1 - 4.2e-07 29.9 1.6 0.039 14.0 0.0 5.1 4 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 CCF34729.1 - 3.7e-05 23.9 15.5 1.2 9.7 0.2 8.1 8 1 1 9 9 9 1 Tetratricopeptide repeat TPR_17 PF13431.1 CCF34729.1 - 4.6e-05 23.3 2.6 1.7 9.0 0.0 5.8 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_7 PF13176.1 CCF34729.1 - 0.00013 21.4 7.7 1.6 8.7 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.1 CCF34729.1 - 0.00014 21.6 12.1 1.7 8.5 0.1 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.1 CCF34729.1 - 0.00031 21.0 10.5 3.8 7.9 0.1 6.5 7 1 0 7 7 7 2 Tetratricopeptide repeat DUF3856 PF12968.2 CCF34729.1 - 0.0007 19.4 1.7 0.053 13.3 0.1 3.4 2 1 0 3 3 3 1 Domain of Unknown Function (DUF3856) TPR_15 PF13429.1 CCF34729.1 - 0.027 13.5 6.8 0.059 12.4 2.1 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat polyprenyl_synt PF00348.12 CCF34730.1 - 1.9e-69 233.4 0.0 2.4e-69 233.0 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Peptidase_M20 PF01546.23 CCF34732.1 - 4.3e-29 101.3 0.1 6.2e-29 100.8 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.12 CCF34732.1 - 0.00085 19.1 0.0 0.002 17.9 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M28 M20_dimer PF07687.9 CCF34732.1 - 0.0023 17.6 0.0 0.0083 15.8 0.0 1.9 1 1 0 1 1 1 1 Peptidase dimerisation domain DUF2834 PF11196.3 CCF34734.1 - 0.048 13.8 0.4 0.2 11.8 0.3 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2834) MARVEL PF01284.18 CCF34735.1 - 3.6e-16 59.2 1.9 4.3e-16 59.0 1.3 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF1469 PF07332.6 CCF34735.1 - 0.012 15.2 5.7 0.35 10.6 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) QCR10 PF09796.4 CCF34735.1 - 0.59 9.8 5.5 2.2 8.0 0.5 2.3 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Tim17 PF02466.14 CCF34736.1 - 7.2e-26 90.7 3.1 9.5e-26 90.3 2.1 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family 5TM-5TMR_LYT PF07694.7 CCF34736.1 - 0.036 13.3 0.9 0.055 12.8 0.6 1.2 1 0 0 1 1 1 0 5TMR of 5TMR-LYT Aspzincin_M35 PF14521.1 CCF34737.1 - 0.11 12.9 0.0 0.15 12.6 0.0 1.1 1 0 0 1 1 1 0 Lysine-specific metallo-endopeptidase CRAL_TRIO PF00650.15 CCF34738.1 - 1.5e-37 128.4 0.0 3.7e-37 127.2 0.0 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 CCF34738.1 - 7.9e-06 25.9 0.6 4.5e-05 23.4 0.2 2.3 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 CCF34738.1 - 0.0033 17.3 0.0 0.01 15.7 0.0 1.8 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain GAT PF03127.9 CCF34740.1 - 7.6e-18 64.3 1.4 2.2e-17 62.8 0.3 2.1 2 0 0 2 2 2 1 GAT domain VHS PF00790.14 CCF34740.1 - 0.00016 21.2 0.0 0.00046 19.8 0.0 1.7 2 0 0 2 2 2 1 VHS domain UBX PF00789.15 CCF34741.1 - 3.5e-07 30.1 0.0 6.7e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 UBX domain SUFU_C PF12470.3 CCF34741.1 - 0.0022 17.6 1.0 0.0034 17.0 0.7 1.3 1 0 0 1 1 1 1 Suppressor of Fused Gli/Ci N terminal binding domain DUF612 PF04747.7 CCF34741.1 - 0.05 12.5 12.7 0.073 11.9 8.8 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF612 DDRGK PF09756.4 CCF34741.1 - 8.2 5.7 14.0 16 4.8 9.7 1.4 1 0 0 1 1 1 0 DDRGK domain HSP20 PF00011.16 CCF34742.1 - 8.9e-13 47.9 0.0 8.1e-12 44.9 0.0 2.1 2 0 0 2 2 2 1 Hsp20/alpha crystallin family Rad51 PF08423.6 CCF34743.1 - 2.5e-137 455.8 0.0 3.2e-137 455.5 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 CCF34743.1 - 7.6e-13 48.2 0.0 1.1e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.1 CCF34743.1 - 3.7e-08 33.4 0.3 1.2e-07 31.7 0.1 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain RecA PF00154.16 CCF34743.1 - 3e-07 29.7 0.1 4e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein KaiC PF06745.8 CCF34743.1 - 1.9e-06 27.1 0.0 3.3e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 KaiC DnaB_C PF03796.10 CCF34743.1 - 0.05 12.4 0.0 0.097 11.5 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain PAXNEB PF05625.6 CCF34743.1 - 0.13 11.0 0.0 0.25 10.1 0.0 1.4 1 0 0 1 1 1 0 PAXNEB protein Nup160 PF11715.3 CCF34744.1 - 2e-135 452.0 1.0 2.6e-135 451.6 0.7 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 TPR_2 PF07719.12 CCF34744.1 - 0.12 12.3 0.1 0.34 10.9 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat LRR_4 PF12799.2 CCF34745.1 - 0.011 15.3 6.2 5.3 6.7 0.5 5.8 4 2 1 5 5 5 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CCF34745.1 - 2 8.2 12.6 3.6 7.4 1.0 5.5 5 1 0 5 5 5 0 Leucine rich repeat Rad9 PF04139.8 CCF34746.1 - 8.3e-68 228.2 0.0 9.9e-68 227.9 0.0 1.1 1 0 0 1 1 1 1 Rad9 RCC1 PF00415.13 CCF34747.1 - 4.3e-32 110.0 10.1 7.4e-10 38.8 0.0 6.7 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CCF34747.1 - 3e-17 61.7 20.2 0.00013 21.5 0.1 6.7 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat PDH PF02153.12 CCF34748.1 - 3.8e-14 52.1 0.1 5.7e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.12 CCF34748.1 - 1.8e-07 31.5 0.0 4e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.10 CCF34748.1 - 2.4e-07 30.7 0.1 5.2e-07 29.6 0.0 1.6 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.14 CCF34748.1 - 2.1e-05 23.7 0.0 3.9e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.11 CCF34748.1 - 0.0044 16.4 0.0 0.0075 15.7 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.13 CCF34748.1 - 0.013 15.1 0.1 0.036 13.7 0.0 1.8 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.13 CCF34748.1 - 0.016 15.1 0.0 0.05 13.6 0.0 1.8 1 0 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.15 CCF34748.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Mpv17_PMP22 PF04117.7 CCF34750.1 - 3.1e-13 49.1 1.9 4.2e-12 45.5 1.4 2.3 2 0 0 2 2 2 1 Mpv17 / PMP22 family EAP30 PF04157.11 CCF34751.1 - 6.9e-67 224.8 0.0 8.3e-67 224.6 0.0 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family Ribosomal_S9 PF00380.14 CCF34752.1 - 7.6e-07 29.4 0.0 8.3e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S9/S16 UCH PF00443.24 CCF34753.1 - 5e-46 156.9 0.1 1.4e-45 155.4 0.1 1.9 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF3517 PF12030.3 CCF34753.1 - 9.7e-21 73.6 0.3 1.5e-20 73.0 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3517) UCH_1 PF13423.1 CCF34753.1 - 2.1e-17 63.5 0.1 3.7e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Pox_A3L PF05288.6 CCF34753.1 - 0.028 14.1 0.4 0.16 11.7 0.0 2.5 2 0 0 2 2 2 0 Poxvirus A3L Protein FANCI_S4 PF14678.1 CCF34753.1 - 0.066 12.3 0.0 0.15 11.1 0.0 1.6 1 0 0 1 1 1 0 FANCI solenoid 4 MFS_1 PF07690.11 CCF34756.1 - 2.7e-17 62.5 41.0 2.7e-17 62.5 28.4 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF34756.1 - 1.2e-05 24.0 10.2 1.2e-05 24.0 7.1 2.8 2 1 1 3 3 3 1 Sugar (and other) transporter DUF2839 PF10999.3 CCF34756.1 - 0.41 10.7 2.8 18 5.4 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2839) adh_short PF00106.20 CCF34758.1 - 6.4e-23 81.4 0.7 8.4e-23 81.0 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF34758.1 - 1.3e-10 41.2 0.5 7.6e-10 38.7 0.3 1.9 1 1 1 2 2 2 1 KR domain adh_short_C2 PF13561.1 CCF34758.1 - 2e-10 40.8 0.2 7.2e-10 39.0 0.2 1.7 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.3 CCF34758.1 - 0.011 15.4 0.2 0.026 14.2 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ParA PF10609.4 CCF34761.1 - 2.1e-35 120.4 0.0 4.2e-35 119.4 0.0 1.5 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 CCF34761.1 - 9.2e-15 54.5 0.0 1.7e-14 53.6 0.0 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.6 CCF34761.1 - 5.7e-08 32.1 0.0 2.4e-06 26.8 0.0 2.1 2 0 0 2 2 2 1 ATPase MipZ AAA_31 PF13614.1 CCF34761.1 - 2.3e-05 24.4 0.1 9.4e-05 22.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.10 CCF34761.1 - 3.5e-05 23.0 0.3 7.5e-05 21.9 0.2 1.5 1 0 0 1 1 1 1 Anion-transporting ATPase ArgK PF03308.11 CCF34761.1 - 0.00085 18.1 0.4 0.0014 17.4 0.3 1.3 1 0 0 1 1 1 1 ArgK protein AAA_25 PF13481.1 CCF34761.1 - 0.001 18.5 0.1 0.0017 17.7 0.1 1.3 1 0 0 1 1 1 1 AAA domain YhjQ PF06564.7 CCF34761.1 - 0.02 14.2 0.4 0.034 13.4 0.1 1.5 2 0 0 2 2 2 0 YhjQ protein AAA_26 PF13500.1 CCF34761.1 - 0.026 14.1 0.2 3 7.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 CCF34761.1 - 0.053 12.7 0.9 0.085 12.0 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF258 APS_kinase PF01583.15 CCF34761.1 - 0.058 13.0 0.1 0.091 12.4 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_16 PF13191.1 CCF34761.1 - 0.23 11.4 0.8 0.62 10.0 0.5 1.7 2 0 0 2 2 2 0 AAA ATPase domain adh_short PF00106.20 CCF34762.1 - 2.9e-29 102.1 0.5 3.9e-29 101.7 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF34762.1 - 6.8e-22 78.4 0.0 8.6e-22 78.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF34762.1 - 1.3e-15 57.5 0.2 1.8e-15 57.0 0.1 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF34762.1 - 0.00034 20.6 0.9 0.00048 20.1 0.6 1.4 1 1 0 1 1 1 1 NADH(P)-binding THF_DHG_CYH_C PF02882.14 CCF34762.1 - 0.012 14.6 0.1 0.023 13.7 0.1 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ADH_zinc_N PF00107.21 CCF34762.1 - 0.023 14.2 0.8 4.9 6.7 0.1 2.4 1 1 0 2 2 2 0 Zinc-binding dehydrogenase Epimerase PF01370.16 CCF34762.1 - 0.043 13.2 0.1 0.055 12.9 0.1 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF1372 PF07116.6 CCF34762.1 - 0.099 12.6 0.0 0.25 11.3 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1372) LysM PF01476.15 CCF34763.1 - 6.6e-07 29.1 0.1 1e-06 28.4 0.1 1.4 1 0 0 1 1 1 1 LysM domain DUF1560 PF07597.6 CCF34763.1 - 0.37 10.8 1.9 0.9 9.5 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1560) Pec_lyase_C PF00544.14 CCF34764.1 - 2.1e-30 105.6 3.1 3.3e-30 105.0 2.1 1.2 1 0 0 1 1 1 1 Pectate lyase V-SNARE_C PF12352.3 CCF34765.1 - 1.5e-14 53.8 0.3 1.5e-14 53.8 0.2 2.8 4 0 0 4 4 4 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 CCF34765.1 - 0.00011 21.8 0.1 0.0013 18.4 0.0 2.5 2 1 1 3 3 3 1 Sec20 Sigma70_r4 PF04545.11 CCF34765.1 - 0.01 15.1 0.0 0.029 13.6 0.0 1.8 1 0 0 1 1 1 1 Sigma-70, region 4 Spc7 PF08317.6 CCF34765.1 - 0.03 12.9 4.3 0.049 12.3 3.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Lipoprotein_6 PF01441.14 CCF34765.1 - 0.12 12.2 3.3 0.2 11.4 2.3 1.3 1 0 0 1 1 1 0 Lipoprotein Syntaxin-6_N PF09177.6 CCF34765.1 - 0.3 11.5 3.3 0.26 11.7 0.3 2.3 3 0 0 3 3 3 0 Syntaxin 6, N-terminal CENP-K PF11802.3 CCF34765.1 - 0.31 10.2 2.2 0.28 10.3 0.5 1.7 2 0 0 2 2 2 0 Centromere-associated protein K RTX_C PF08339.5 CCF34765.1 - 0.46 10.1 5.2 0.22 11.2 1.3 2.1 1 1 1 2 2 2 0 RTX C-terminal domain TPR_MLP1_2 PF07926.7 CCF34765.1 - 1.2 8.8 7.6 6.5 6.5 4.5 2.6 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein MFS_1 PF07690.11 CCF34766.1 - 2.6e-52 177.7 23.9 2.6e-52 177.7 16.6 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF34766.1 - 1.8e-09 36.7 9.9 1.8e-09 36.7 6.9 2.8 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.8 CCF34766.1 - 1.3e-05 23.6 5.5 2.4e-05 22.7 3.8 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF791 PF05631.9 CCF34766.1 - 5.9e-05 21.9 5.1 7.1e-05 21.6 1.2 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF791) MFS_3 PF05977.8 CCF34766.1 - 0.0019 16.3 6.1 0.0019 16.3 4.2 1.8 2 0 0 2 2 2 1 Transmembrane secretion effector MFS_1_like PF12832.2 CCF34766.1 - 0.024 14.4 1.2 0.024 14.4 0.8 3.8 4 0 0 4 4 4 0 MFS_1 like family OATP PF03137.15 CCF34766.1 - 0.18 9.8 4.7 0.14 10.1 0.4 2.2 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Fzo_mitofusin PF04799.8 CCF34766.1 - 1.4 8.3 3.8 6.2 6.1 0.8 2.4 2 0 0 2 2 2 0 fzo-like conserved region GFA PF04828.9 CCF34767.1 - 7.3e-14 51.4 11.8 3.1e-09 36.6 0.4 2.8 3 0 0 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme NOB1_Zn_bind PF08772.6 CCF34767.1 - 0.12 12.2 4.2 4.8 7.0 0.3 2.7 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Zn_clus PF00172.13 CCF34768.1 - 1.2e-07 31.4 11.5 1.7e-07 31.0 7.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Macro PF01661.16 CCF34768.1 - 0.012 15.5 0.0 0.013 15.3 0.0 1.0 1 0 0 1 1 1 0 Macro domain Dickkopf_N PF04706.7 CCF34768.1 - 4.6 7.4 13.1 3.9 7.6 4.0 2.1 1 1 1 2 2 2 0 Dickkopf N-terminal cysteine-rich region PTR2 PF00854.16 CCF34770.1 - 7.5e-48 163.1 9.2 1e-47 162.7 6.3 1.2 1 0 0 1 1 1 1 POT family Glycos_transf_2 PF00535.21 CCF34772.1 - 1.4e-33 115.9 0.0 1.6e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 CCF34772.1 - 6.7e-13 48.9 0.0 1.1e-12 48.2 0.0 1.3 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 CCF34772.1 - 4.1e-09 35.9 0.0 5.4e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 CCF34772.1 - 1.3e-05 24.5 0.0 2.1e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 adh_short PF00106.20 CCF34773.1 - 1.9e-34 118.9 2.5 2.7e-34 118.5 1.7 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF34773.1 - 1.7e-27 96.7 0.1 2.6e-27 96.1 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF34773.1 - 6e-17 61.8 1.3 8e-17 61.4 0.9 1.1 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.13 CCF34773.1 - 0.0038 16.9 0.7 0.0063 16.1 0.5 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.16 CCF34773.1 - 0.0056 16.5 0.7 0.0085 15.9 0.5 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Gly_rich_SFCGS PF14272.1 CCF34773.1 - 0.0065 16.3 0.4 0.016 15.1 0.3 1.7 1 0 0 1 1 1 1 Glycine-rich SFCGS UDPG_MGDP_dh_N PF03721.9 CCF34773.1 - 0.027 13.8 0.6 0.068 12.5 0.2 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain THF_DHG_CYH_C PF02882.14 CCF34773.1 - 0.031 13.3 0.2 0.069 12.2 0.1 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.14 CCF34773.1 - 0.1 11.7 0.2 0.16 11.0 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Frankia_peptide PF14407.1 CCF34774.1 - 0.059 13.1 0.6 0.12 12.1 0.4 1.5 1 0 0 1 1 1 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. SAC3_GANP PF03399.11 CCF34774.1 - 0.079 12.5 0.2 0.12 11.9 0.1 1.3 1 0 0 1 1 1 0 SAC3/GANP/Nin1/mts3/eIF-3 p25 family Ank_2 PF12796.2 CCF34775.1 - 3.3e-06 27.3 0.0 4.9e-05 23.5 0.0 2.7 2 1 1 3 3 3 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 CCF34775.1 - 0.0005 20.0 1.5 0.13 12.5 0.0 3.7 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.1 CCF34775.1 - 0.0031 17.9 1.5 0.029 14.8 0.1 3.3 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank PF00023.25 CCF34775.1 - 0.015 15.0 0.9 0.31 10.9 0.0 3.1 3 0 0 3 3 3 0 Ankyrin repeat Ank_5 PF13857.1 CCF34775.1 - 0.079 13.2 1.1 2.4 8.5 0.0 3.4 2 1 1 3 3 3 0 Ankyrin repeats (many copies) AATase PF07247.7 CCF34776.1 - 1.3e-26 93.2 0.0 2.7e-26 92.1 0.0 1.5 1 1 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.15 CCF34776.1 - 1.4e-07 30.6 0.3 4e-06 25.8 0.0 2.1 2 0 0 2 2 2 2 Condensation domain WES_acyltransf PF03007.11 CCF34776.1 - 0.0027 17.3 0.1 0.0068 16.0 0.0 1.7 2 0 0 2 2 2 1 Wax ester synthase-like Acyl-CoA acyltransferase domain Sedlin_N PF04628.8 CCF34778.1 - 9.8e-44 148.4 0.0 1.1e-43 148.2 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.7 CCF34778.1 - 9.9e-05 22.0 0.2 0.008 15.8 0.0 2.2 1 1 1 2 2 2 2 Sybindin-like family Histone PF00125.19 CCF34779.1 - 1.8e-15 56.7 0.1 2.2e-15 56.5 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.12 CCF34779.1 - 0.00012 21.9 0.1 0.00017 21.4 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.1 CCF34779.1 - 0.00012 22.1 0.1 0.00017 21.7 0.0 1.4 1 1 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 CCF34779.1 - 0.00033 20.6 0.1 0.00059 19.8 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 CCF34779.1 - 0.013 15.2 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated CENP-T PF15511.1 CCF34779.1 - 0.022 14.0 0.0 0.022 14.0 0.0 1.0 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T TPR_1 PF00515.23 CCF34780.1 - 1.5e-38 128.8 20.6 8e-07 28.4 0.1 9.7 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_11 PF13414.1 CCF34780.1 - 6.1e-35 118.6 25.6 6.6e-11 41.7 1.1 7.7 4 2 4 8 8 8 8 TPR repeat TPR_2 PF07719.12 CCF34780.1 - 3.6e-29 98.3 29.7 0.00013 21.6 0.1 10.8 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_8 PF13181.1 CCF34780.1 - 5.6e-26 88.3 3.5 7.4e-05 22.2 0.0 9.6 10 0 0 10 10 10 6 Tetratricopeptide repeat Apc3 PF12895.2 CCF34780.1 - 1.8e-25 88.8 15.4 1.6e-19 69.7 0.1 5.3 4 1 0 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 CCF34780.1 - 1e-21 75.2 11.7 0.21 11.8 0.0 9.9 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_12 PF13424.1 CCF34780.1 - 1.3e-19 69.9 23.2 0.00019 21.3 0.0 8.1 4 2 4 8 8 8 7 Tetratricopeptide repeat TPR_16 PF13432.1 CCF34780.1 - 5.2e-19 68.3 25.2 9.6e-06 26.1 0.6 8.2 6 1 2 8 8 8 6 Tetratricopeptide repeat TPR_14 PF13428.1 CCF34780.1 - 5.9e-19 66.8 17.9 0.4 11.4 0.0 10.4 4 2 7 11 11 11 5 Tetratricopeptide repeat TPR_19 PF14559.1 CCF34780.1 - 1e-17 64.1 13.9 2.5e-05 24.5 0.5 7.4 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_7 PF13176.1 CCF34780.1 - 4.3e-16 57.3 10.8 0.031 14.0 0.0 7.9 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_6 PF13174.1 CCF34780.1 - 1.1e-09 38.1 8.1 2 9.0 0.0 8.7 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_15 PF13429.1 CCF34780.1 - 1.1e-06 27.9 11.1 0.069 12.2 0.0 4.5 2 2 1 4 4 4 4 Tetratricopeptide repeat DUF2225 PF09986.4 CCF34780.1 - 7.3e-05 22.3 3.7 0.15 11.5 1.0 3.7 2 1 2 4 4 4 2 Uncharacterized protein conserved in bacteria (DUF2225) EIF_2_alpha PF07541.7 CCF34780.1 - 1.3 8.7 3.3 4.1 7.1 0.1 3.3 4 1 1 5 5 5 0 Eukaryotic translation initiation factor 2 alpha subunit RGS PF00615.14 CCF34782.1 - 1.6e-05 24.9 0.0 0.00014 21.8 0.0 2.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain DUF2892 PF11127.3 CCF34782.1 - 3.6 7.4 6.9 11 5.9 4.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2892) GTP_EFTU PF00009.22 CCF34783.1 - 1.2e-49 168.3 0.0 2.1e-49 167.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.5 CCF34783.1 - 8.7e-21 73.8 1.6 1.7e-20 72.9 1.1 1.5 1 0 0 1 1 1 1 HBS1 N-terminus MMR_HSR1 PF01926.18 CCF34783.1 - 5.6e-09 35.9 0.0 1.5e-07 31.3 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 CCF34783.1 - 3.5e-08 33.4 0.3 1.1e-07 31.8 0.2 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.12 CCF34783.1 - 1.5e-07 31.4 0.0 3.9e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D4 PF14578.1 CCF34783.1 - 2.1e-05 24.0 0.0 4.6e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Miro PF08477.8 CCF34783.1 - 6.9e-05 23.3 0.0 0.029 14.8 0.0 2.6 2 0 0 2 2 2 1 Miro-like protein Ras PF00071.17 CCF34783.1 - 0.0038 16.6 0.1 0.061 12.7 0.0 2.3 2 0 0 2 2 2 1 Ras family Septin PF00735.13 CCF34783.1 - 0.005 15.8 0.0 0.0084 15.1 0.0 1.2 1 0 0 1 1 1 1 Septin SRPRB PF09439.5 CCF34783.1 - 0.046 12.9 0.0 1.9 7.6 0.0 2.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit FeoB_N PF02421.13 CCF34783.1 - 0.06 12.6 0.0 0.99 8.6 0.0 2.6 2 1 0 2 2 2 0 Ferrous iron transport protein B MCM2_N PF12619.3 CCF34783.1 - 2.6 8.0 11.1 0.19 11.7 3.9 1.8 2 0 0 2 2 2 0 Mini-chromosome maintenance protein 2 Cpn60_TCP1 PF00118.19 CCF34784.1 - 5.6e-149 496.8 2.9 6.4e-149 496.6 2.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Enolase_N PF03952.11 CCF34784.1 - 0.16 11.8 2.1 34 4.3 0.0 3.3 3 0 0 3 3 3 0 Enolase, N-terminal domain His_Phos_1 PF00300.17 CCF34785.1 - 0.0042 17.1 0.6 0.031 14.3 0.0 2.0 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) LigB PF02900.13 CCF34785.1 - 0.14 11.1 0.0 0.16 10.9 0.0 1.1 1 0 0 1 1 1 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase HTH_OrfB_IS605 PF12323.3 CCF34785.1 - 0.23 10.8 1.6 2.1 7.7 0.2 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain MFS_1 PF07690.11 CCF34786.1 - 5.8e-19 68.0 57.6 2.1e-11 43.1 20.0 3.4 2 1 0 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF34786.1 - 8.1e-08 30.9 22.8 1.1e-07 30.4 15.8 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF4225 PF13988.1 CCF34786.1 - 0.0074 15.7 0.6 0.025 14.0 0.4 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF4225) HET PF06985.6 CCF34787.1 - 2.5e-23 82.7 0.0 5.5e-23 81.6 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) TrbC_Ftype PF09673.5 CCF34788.1 - 5.5 6.6 6.7 2.8 7.5 0.7 2.8 2 1 1 3 3 3 0 Type-F conjugative transfer system pilin assembly protein Chitin_synth_2 PF03142.10 CCF34789.1 - 1.1e-24 86.7 1.2 2.2e-24 85.7 0.8 1.4 1 1 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.1 CCF34789.1 - 1.5e-13 51.0 0.5 2.5e-13 50.3 0.4 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 CCF34789.1 - 1.4e-11 44.4 3.0 2.2e-11 43.8 2.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.21 CCF34789.1 - 0.011 15.4 0.0 0.041 13.5 0.0 1.9 2 0 0 2 2 2 0 Glycosyl transferase family 2 AMP-binding PF00501.23 CCF34790.1 - 1.3e-79 267.6 0.0 1.8e-79 267.0 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.15 CCF34790.1 - 1.8e-28 99.3 0.0 4.4e-28 98.0 0.0 1.7 1 1 0 1 1 1 1 Condensation domain PP-binding PF00550.20 CCF34790.1 - 1.9e-06 28.0 0.1 4.5e-06 26.8 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site WES_acyltransf PF03007.11 CCF34790.1 - 0.05 13.1 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain Cas_csx3 PF09620.5 CCF34794.1 - 0.0062 16.3 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_csx3) Glyco_hydro_43 PF04616.9 CCF34795.1 - 3.4e-64 216.6 2.9 4.2e-64 216.4 2.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 E1-E2_ATPase PF00122.15 CCF34796.1 - 4.4e-20 71.7 0.0 7.5e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 CCF34796.1 - 1.3e-19 71.1 0.1 6.8e-19 68.7 0.0 2.2 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CCF34796.1 - 7.1e-15 55.9 2.0 8.9e-14 52.4 1.4 2.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF34796.1 - 4.7e-12 45.7 0.0 1.2e-11 44.3 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 CCF34796.1 - 0.0021 17.6 0.3 0.006 16.1 0.2 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 CCF34796.1 - 0.084 13.0 0.0 0.27 11.4 0.0 1.8 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Cript PF10235.4 CCF34797.1 - 0.0009 19.5 0.0 0.0009 19.5 0.0 1.4 2 0 0 2 2 2 1 Microtubule-associated protein CRIPT Asp PF00026.18 CCF34798.1 - 1.4e-59 201.9 2.3 1.7e-59 201.6 1.6 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CCF34798.1 - 5.1e-08 33.0 0.1 1.1e-06 28.6 0.0 2.6 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 CCF34798.1 - 1.6e-05 25.3 0.2 0.074 13.5 0.0 3.2 2 2 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.1 CCF34798.1 - 0.017 14.6 0.0 0.072 12.6 0.0 2.0 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal Glyco_hydro_17 PF00332.13 CCF34799.1 - 7e-25 87.7 0.3 5.2e-24 84.8 0.2 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 DUF1034 PF06280.7 CCF34802.1 - 2.3e-08 34.4 0.0 8.7e-08 32.5 0.0 1.8 2 0 0 2 2 2 1 Fn3-like domain (DUF1034) DUF916 PF06030.7 CCF34802.1 - 0.024 14.4 0.0 0.041 13.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF916) Peptidase_S8 PF00082.17 CCF34802.1 - 0.11 11.6 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Subtilase family adh_short PF00106.20 CCF34803.1 - 1e-27 97.0 2.7 1.3e-27 96.7 1.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF34803.1 - 2.8e-19 69.8 0.0 3.4e-19 69.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF34803.1 - 2.6e-09 36.9 0.9 3.9e-09 36.4 0.6 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF34803.1 - 0.038 14.0 0.3 0.062 13.3 0.2 1.4 1 0 0 1 1 1 0 NADH(P)-binding MR_MLE_C PF13378.1 CCF34804.1 - 3.7e-20 71.9 0.0 7.3e-20 70.9 0.0 1.5 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE PF01188.16 CCF34804.1 - 1.4e-12 47.9 0.0 2.7e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MR_MLE_N PF02746.11 CCF34804.1 - 3.7e-09 36.6 0.0 8.5e-09 35.4 0.0 1.5 2 0 0 2 2 2 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Glyco_hydro_42 PF02449.10 CCF34804.1 - 0.028 13.5 0.0 0.23 10.5 0.0 1.9 2 0 0 2 2 2 0 Beta-galactosidase Nuc_deoxyrib_tr PF05014.10 CCF34805.1 - 0.0012 18.7 0.0 0.0013 18.5 0.0 1.2 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase Peptidase_M20 PF01546.23 CCF34806.1 - 8.6e-23 80.8 0.0 2.2e-22 79.4 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 WD40 PF00400.27 CCF34806.1 - 8.1e-19 66.7 0.1 0.0021 17.8 0.0 5.9 5 0 0 5 5 5 5 WD domain, G-beta repeat M20_dimer PF07687.9 CCF34806.1 - 0.00098 18.8 0.0 0.0019 17.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Nucleoporin_N PF08801.6 CCF34806.1 - 0.019 13.7 0.0 1.6 7.3 0.0 2.9 2 1 1 3 3 3 0 Nup133 N terminal like Invas_SpaK PF03519.9 CCF34806.1 - 0.049 13.4 0.6 0.94 9.3 0.0 2.8 3 0 0 3 3 3 0 Invasion protein B family Peptidase_M28 PF04389.12 CCF34806.1 - 0.063 13.0 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 Peptidase family M28 Asparaginase_2 PF01112.13 CCF34807.1 - 1.1e-15 57.2 0.0 1.3e-15 56.9 0.0 1.1 1 0 0 1 1 1 1 Asparaginase Ribosomal_L24e PF01246.15 CCF34809.1 - 1.3e-30 105.0 0.3 1.3e-30 105.0 0.2 1.8 2 0 0 2 2 2 1 Ribosomal protein L24e A_deamin PF02137.13 CCF34810.1 - 3.9e-64 217.1 0.0 4.6e-64 216.9 0.0 1.0 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain NAC PF01849.13 CCF34811.1 - 5.5e-22 77.0 0.1 2.3e-21 75.0 0.1 1.9 2 0 0 2 2 2 1 NAC domain CBP4 PF07960.6 CCF34812.1 - 1e-08 34.8 1.8 1.1e-08 34.6 1.2 1.0 1 0 0 1 1 1 1 CBP4 Alba PF01918.16 CCF34813.1 - 0.00015 21.2 0.1 0.00043 19.8 0.0 1.7 2 0 0 2 2 2 1 Alba PDE8 PF08629.5 CCF34813.1 - 0.044 13.5 0.4 0.086 12.6 0.3 1.4 1 0 0 1 1 1 0 PDE8 phosphodiesterase DUF202 PF02656.10 CCF34814.1 - 1.8e-13 50.5 5.9 2.2e-13 50.2 2.5 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF1430 PF07242.6 CCF34814.1 - 0.18 11.8 1.2 3.3 7.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1430) Phageshock_PspG PF09583.5 CCF34814.1 - 0.32 11.0 0.3 0.32 11.0 0.2 2.4 3 0 0 3 3 3 0 Phage shock protein G (Phageshock_PspG) 7TMR-DISM_7TM PF07695.6 CCF34814.1 - 1.2 8.7 9.3 4.6 6.8 6.5 1.8 1 1 0 1 1 1 0 7TM diverse intracellular signalling Tctex-1 PF03645.8 CCF34815.1 - 8.8e-34 115.4 0.0 1e-33 115.1 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family tRNA_int_endo PF01974.12 CCF34816.1 - 1.3e-18 66.5 0.0 2.8e-18 65.5 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.9 CCF34816.1 - 0.0015 18.0 0.0 0.17 11.4 0.0 2.5 2 0 0 2 2 2 2 tRNA intron endonuclease, N-terminal domain Glyco_tranf_2_3 PF13641.1 CCF34817.1 - 1.3e-12 48.0 0.0 5.1e-12 46.0 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 CCF34817.1 - 1.6e-12 47.0 0.0 0.00074 18.8 0.0 3.3 3 0 0 3 3 3 3 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 CCF34817.1 - 0.00029 20.5 0.0 0.0033 17.1 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 2 EF-hand_7 PF13499.1 CCF34818.1 - 2.9e-09 36.9 0.0 0.0003 20.8 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 CCF34818.1 - 4.9e-07 28.6 0.0 0.0028 16.8 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 CCF34818.1 - 3.4e-05 23.3 0.0 0.014 15.2 0.0 2.8 2 1 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 CCF34818.1 - 0.0034 16.9 0.1 0.011 15.3 0.0 1.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.2 CCF34818.1 - 0.014 15.1 0.0 0.88 9.3 0.0 2.1 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand ParA PF10609.4 CCF34819.1 - 1.7e-32 111.1 0.3 3.8e-32 110.0 0.2 1.6 2 0 0 2 2 2 1 ParA/MinD ATPase like CbiA PF01656.18 CCF34819.1 - 2.7e-16 59.5 0.1 3.7e-16 59.1 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 CCF34819.1 - 2.8e-09 37.0 0.0 1.6e-08 34.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain MipZ PF09140.6 CCF34819.1 - 4.9e-05 22.5 0.0 6.4e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.13 CCF34819.1 - 6.7e-05 22.2 0.0 0.12 11.5 0.0 2.3 2 1 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.10 CCF34819.1 - 0.00011 21.3 0.4 0.0028 16.7 0.0 2.7 2 1 1 3 3 3 1 Anion-transporting ATPase AAA_26 PF13500.1 CCF34819.1 - 0.0018 17.8 0.0 0.21 11.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain YhjQ PF06564.7 CCF34819.1 - 0.01 15.2 0.2 0.054 12.8 0.0 1.9 2 0 0 2 2 2 0 YhjQ protein AAA_25 PF13481.1 CCF34819.1 - 0.021 14.2 0.3 0.042 13.2 0.2 1.6 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 CCF34819.1 - 0.11 12.2 0.5 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 Part of AAA domain DUF4537 PF15057.1 CCF34820.1 - 0.0091 15.7 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) IL6 PF00489.12 CCF34820.1 - 0.011 15.3 0.2 0.02 14.5 0.2 1.3 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family FlxA PF14282.1 CCF34820.1 - 0.013 15.4 0.8 0.013 15.4 0.6 1.8 2 0 0 2 2 2 0 FlxA-like protein Cep57_MT_bd PF06657.8 CCF34820.1 - 0.027 14.3 1.5 0.079 12.9 1.0 1.8 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 LBR_tudor PF09465.5 CCF34820.1 - 0.05 13.2 0.0 0.087 12.4 0.0 1.4 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain DUF4610 PF15384.1 CCF34820.1 - 0.082 12.4 0.5 0.16 11.4 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4610) Rad9_Rad53_bind PF08605.5 CCF34820.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Fungal Rad9-like Rad53-binding TCO89 PF10452.4 CCF34821.1 - 4.8e-06 25.7 2.6 0.00018 20.5 0.1 3.3 3 0 0 3 3 3 2 TORC1 subunit TCO89 Beta_elim_lyase PF01212.16 CCF34822.1 - 5.1e-70 235.8 0.0 6.3e-70 235.5 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 CCF34822.1 - 1.1e-05 23.8 0.0 2.2e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 CCF34822.1 - 0.00068 18.6 0.0 0.0009 18.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 CCF34822.1 - 0.014 14.2 0.0 0.02 13.6 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 CCF34822.1 - 0.026 13.5 0.0 0.048 12.7 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Trehalase PF01204.13 CCF34823.1 - 1.4e-119 400.1 9.8 9.5e-119 397.3 6.8 1.9 1 1 0 1 1 1 1 Trehalase GDE_C PF06202.9 CCF34823.1 - 0.00015 20.6 0.6 0.0014 17.3 0.0 2.0 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase DUF1227 PF06777.6 CCF34825.1 - 3.9e-62 208.2 0.2 1e-61 206.9 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1227) DEAD_2 PF06733.10 CCF34825.1 - 2.4e-52 176.8 0.4 4.3e-52 176.0 0.3 1.5 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.1 CCF34825.1 - 3.5e-44 150.6 0.0 1e-43 149.1 0.0 1.8 2 0 0 2 2 2 1 Helicase C-terminal domain SNF2_N PF00176.18 CCF34825.1 - 4.3e-05 22.4 0.0 0.00018 20.4 0.0 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 CCF34825.1 - 0.00036 20.0 0.0 0.076 12.5 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_11 PF13086.1 CCF34825.1 - 0.0038 16.8 0.3 0.0096 15.5 0.2 1.7 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 CCF34825.1 - 0.0097 15.7 0.0 0.035 13.9 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 CCF34825.1 - 0.013 15.6 0.1 1.4 9.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain PhoH PF02562.11 CCF34825.1 - 0.052 12.7 0.1 3.9 6.6 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein Stomoxyn PF11585.3 CCF34825.1 - 0.053 13.3 0.2 0.13 12.1 0.1 1.6 1 0 0 1 1 1 0 Insect antimicrobial peptide, stomoxyn DUF2075 PF09848.4 CCF34825.1 - 0.058 12.3 0.1 2 7.3 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.1 CCF34825.1 - 0.073 12.8 0.0 0.35 10.6 0.0 2.1 2 0 0 2 2 2 0 Part of AAA domain DDHD PF02862.12 CCF34826.1 - 6.4e-39 134.0 0.0 1.6e-20 73.8 0.0 2.0 1 1 0 2 2 2 2 DDHD domain UPF0154 PF03672.8 CCF34826.1 - 0.16 11.6 0.0 0.3 10.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) Tyrosinase PF00264.15 CCF34828.1 - 3.1e-53 181.2 2.9 3.1e-53 181.2 2.0 1.6 2 0 0 2 2 2 1 Common central domain of tyrosinase ABC_membrane PF00664.18 CCF34829.1 - 4e-38 131.4 32.1 3.1e-23 82.5 8.6 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 CCF34829.1 - 3.3e-35 121.3 0.0 4.1e-16 59.5 0.0 3.1 3 0 0 3 3 2 2 ABC transporter AAA_21 PF13304.1 CCF34829.1 - 1.3e-08 35.2 0.5 0.0045 17.0 0.1 3.2 3 0 0 3 3 3 2 AAA domain T2SE PF00437.15 CCF34829.1 - 9.9e-08 31.2 0.4 0.0098 14.8 0.1 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_16 PF13191.1 CCF34829.1 - 2e-07 31.1 0.1 0.015 15.2 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 CCF34829.1 - 4e-07 30.2 0.1 0.025 14.7 0.0 3.3 3 1 0 3 3 2 2 AAA domain AAA_33 PF13671.1 CCF34829.1 - 6.9e-07 29.2 0.0 0.0024 17.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.14 CCF34829.1 - 1.3e-06 27.8 0.0 0.0025 17.0 0.0 2.8 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 CCF34829.1 - 6.9e-06 25.5 1.5 0.0016 17.9 0.2 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain SbcCD_C PF13558.1 CCF34829.1 - 1.8e-05 24.5 0.1 0.64 9.9 0.0 3.7 3 1 0 3 3 2 2 Putative exonuclease SbcCD, C subunit DUF258 PF03193.11 CCF34829.1 - 0.00015 20.9 2.0 0.045 12.9 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_25 PF13481.1 CCF34829.1 - 0.00043 19.7 0.6 1 8.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 CCF34829.1 - 0.0005 20.8 0.0 1.6 9.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain UPF0079 PF02367.12 CCF34829.1 - 0.00073 19.1 1.2 0.022 14.3 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 FtsK_SpoIIIE PF01580.13 CCF34829.1 - 0.0014 18.1 0.1 0.0051 16.3 0.0 1.8 2 0 0 2 2 2 1 FtsK/SpoIIIE family Miro PF08477.8 CCF34829.1 - 0.0016 18.9 0.3 0.49 10.9 0.0 2.7 2 0 0 2 2 2 1 Miro-like protein Zeta_toxin PF06414.7 CCF34829.1 - 0.0018 17.4 2.6 0.25 10.4 0.1 3.0 3 0 0 3 3 3 1 Zeta toxin AAA_10 PF12846.2 CCF34829.1 - 0.002 17.6 0.3 0.88 8.9 0.0 2.5 2 0 0 2 2 2 1 AAA-like domain MobB PF03205.9 CCF34829.1 - 0.003 17.2 1.2 1.6 8.4 0.0 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 CCF34829.1 - 0.0032 17.7 0.2 1.5 9.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 CCF34829.1 - 0.017 15.3 0.1 1.3 9.2 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.10 CCF34829.1 - 0.017 14.8 0.5 1.3 8.6 0.0 2.3 2 0 0 2 2 2 0 NTPase AAA_14 PF13173.1 CCF34829.1 - 0.021 14.7 0.1 3.9 7.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 CCF34829.1 - 0.025 14.5 0.4 1.2 9.1 0.0 2.8 3 0 0 3 3 2 0 50S ribosome-binding GTPase Mg_chelatase PF01078.16 CCF34829.1 - 0.038 13.1 0.0 1.3 8.1 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Viral_helicase1 PF01443.13 CCF34829.1 - 0.046 13.2 0.8 3.2 7.2 0.1 2.9 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.1 CCF34829.1 - 0.046 14.0 0.3 1.4 9.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 CCF34829.1 - 0.053 13.1 3.8 3.1 7.4 0.1 3.8 4 0 0 4 4 4 0 NACHT domain Arch_ATPase PF01637.13 CCF34829.1 - 0.055 13.1 0.2 8.5 5.9 0.0 2.4 2 0 0 2 2 2 0 Archaeal ATPase Dynamin_N PF00350.18 CCF34829.1 - 0.055 13.2 1.9 3.1 7.6 0.1 2.5 2 0 0 2 2 2 0 Dynamin family GTP_EFTU PF00009.22 CCF34829.1 - 0.056 12.8 0.0 4.7 6.6 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain cobW PF02492.14 CCF34829.1 - 0.063 12.7 3.6 2.3 7.6 0.1 2.7 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain DEAD PF00270.24 CCF34829.1 - 0.064 12.7 0.1 2.9 7.3 0.0 2.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase PduV-EutP PF10662.4 CCF34829.1 - 0.1 12.0 0.7 3 7.3 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.12 CCF34829.1 - 0.11 12.0 1.3 9.3 5.7 0.2 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein RNA_helicase PF00910.17 CCF34829.1 - 0.24 11.5 0.9 17 5.6 0.0 2.9 3 0 0 3 3 2 0 RNA helicase Guanylate_kin PF00625.16 CCF34829.1 - 0.37 10.2 1.4 3.5 7.0 0.0 2.5 3 0 0 3 3 2 0 Guanylate kinase Septin PF00735.13 CCF34829.1 - 0.43 9.5 0.8 15 4.4 0.1 2.4 2 0 0 2 2 2 0 Septin Kp4 PF09044.5 CCF34830.1 - 4.2e-33 113.8 0.4 6.5e-33 113.2 0.3 1.2 1 0 0 1 1 1 1 Kp4 MU117 PF15474.1 CCF34830.1 - 0.029 14.8 0.0 0.04 14.3 0.0 1.3 1 0 0 1 1 1 0 Meiotically up-regulated gene family AAA_12 PF13087.1 CCF34832.1 - 9.3e-18 64.3 0.0 1.5e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 CCF34832.1 - 1.7e-10 40.8 0.0 6e-10 39.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.1 CCF34832.1 - 2.2e-07 30.6 0.1 0.0015 18.1 0.3 2.6 2 1 0 2 2 2 2 AAA domain AAA_25 PF13481.1 CCF34832.1 - 5.3e-06 25.9 0.1 4.2e-05 23.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CCF34832.1 - 3.6e-05 23.4 0.0 0.00012 21.7 0.0 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 CCF34832.1 - 0.0016 18.6 0.1 0.018 15.1 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.1 CCF34832.1 - 0.0041 17.0 0.6 0.022 14.6 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 CCF34832.1 - 0.007 16.6 0.1 0.02 15.2 0.0 1.7 2 0 0 2 2 1 1 AAA domain NACHT PF05729.7 CCF34832.1 - 0.0085 15.7 0.0 0.019 14.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain KTI12 PF08433.5 CCF34832.1 - 0.009 15.2 0.0 0.017 14.3 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.1 CCF34832.1 - 0.019 15.7 0.1 0.061 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain CbiA PF01656.18 CCF34832.1 - 0.021 14.2 0.2 0.82 9.0 0.1 2.4 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_10 PF12846.2 CCF34832.1 - 0.031 13.6 0.1 0.082 12.3 0.1 1.6 1 1 0 1 1 1 0 AAA-like domain Zot PF05707.7 CCF34832.1 - 0.038 13.4 0.1 9.2 5.6 0.0 2.4 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) AAA_28 PF13521.1 CCF34832.1 - 0.045 13.6 0.3 0.19 11.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.12 CCF34832.1 - 0.051 13.0 0.0 0.19 11.0 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein NTPase_1 PF03266.10 CCF34832.1 - 0.063 12.9 0.1 0.57 9.8 0.1 2.5 3 1 0 3 3 3 0 NTPase AAA_34 PF13872.1 CCF34832.1 - 0.085 11.6 0.1 0.13 10.9 0.1 1.2 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 T2SE PF00437.15 CCF34832.1 - 0.14 11.0 0.0 0.29 9.9 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein SRP54 PF00448.17 CCF34832.1 - 0.17 11.3 0.4 0.42 10.0 0.1 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA PF00004.24 CCF34832.1 - 0.19 11.9 0.3 0.81 9.8 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ADH_N PF08240.7 CCF34834.1 - 1.5e-19 69.7 0.1 5.1e-19 68.0 0.0 1.9 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain HI0933_like PF03486.9 CCF34834.1 - 0.0004 18.9 0.3 0.00049 18.6 0.2 1.1 1 0 0 1 1 1 1 HI0933-like protein ADH_zinc_N PF00107.21 CCF34834.1 - 0.0013 18.3 0.3 0.5 9.9 0.1 2.2 2 0 0 2 2 2 2 Zinc-binding dehydrogenase Pyr_redox_3 PF13738.1 CCF34834.1 - 0.13 12.2 0.6 1.1 9.2 0.1 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF34834.1 - 0.3 9.9 1.2 0.42 9.4 0.8 1.2 1 0 0 1 1 1 0 FAD binding domain ADH_N_assoc PF13823.1 CCF34834.1 - 0.47 10.1 3.7 0.38 10.4 0.3 2.5 2 0 0 2 2 2 0 Alcohol dehydrogenase GroES-associated MFS_1 PF07690.11 CCF34835.1 - 1.5e-40 138.9 20.4 1.5e-40 138.9 14.1 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF1616 PF07760.6 CCF34835.1 - 0.0073 15.4 3.4 0.18 10.8 0.5 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1616) ATG22 PF11700.3 CCF34835.1 - 0.099 11.1 14.2 0.0081 14.6 3.8 2.8 2 1 1 3 3 3 0 Vacuole effluxer Atg22 like DUF1228 PF06779.9 CCF34835.1 - 0.67 10.0 5.7 0.61 10.1 0.1 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1228) Pec_lyase_C PF00544.14 CCF34836.1 - 4e-23 81.9 5.4 5.7e-23 81.4 3.7 1.2 1 0 0 1 1 1 1 Pectate lyase ERCC4 PF02732.10 CCF34837.1 - 8e-23 80.7 0.1 1.3e-22 80.0 0.0 1.3 1 0 0 1 1 1 1 ERCC4 domain CAF-1_p150 PF11600.3 CCF34837.1 - 0.00059 19.2 12.7 0.00059 19.2 8.8 2.0 2 0 0 2 2 2 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Ycf1 PF05758.7 CCF34837.1 - 0.034 11.8 3.6 0.051 11.2 2.5 1.1 1 0 0 1 1 1 0 Ycf1 XRN_N PF03159.13 CCF34837.1 - 0.39 10.0 9.2 0.097 12.0 0.1 2.3 2 0 0 2 2 2 0 XRN 5'-3' exonuclease N-terminus SAPS PF04499.10 CCF34837.1 - 8.8 4.8 10.5 20 3.6 7.3 1.5 1 1 0 1 1 1 0 SIT4 phosphatase-associated protein His_Phos_1 PF00300.17 CCF34838.1 - 5.1e-21 75.4 0.0 7.9e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.17 CCF34838.1 - 0.048 12.9 0.2 0.08 12.2 0.1 1.3 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) DARPP-32 PF05395.7 CCF34839.1 - 0.032 14.3 0.8 0.051 13.7 0.3 1.4 1 1 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 DUF3934 PF13070.1 CCF34839.1 - 0.041 14.1 1.0 0.041 14.1 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3934) Glyco_transf_90 PF05686.7 CCF34840.1 - 2.9e-09 36.0 0.0 0.00034 19.4 0.0 3.3 3 1 0 3 3 3 3 Glycosyl transferase family 90 ADH_zinc_N PF00107.21 CCF34844.1 - 4.9e-15 55.2 0.0 8.4e-15 54.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF34844.1 - 5.9e-09 36.8 0.0 1.5e-08 35.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF34844.1 - 3.5e-06 26.7 0.1 6.5e-06 25.8 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF676 PF05057.9 CCF34845.1 - 3.2e-05 23.3 0.0 4.9e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.2 CCF34845.1 - 0.012 15.5 0.1 0.038 13.8 0.1 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family F_bP_aldolase PF01116.15 CCF34846.1 - 6.9e-71 238.6 0.0 7.7e-71 238.5 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Trns_repr_metal PF02583.12 CCF34846.1 - 0.063 13.4 0.1 0.24 11.6 0.0 2.0 1 0 0 1 1 1 0 Metal-sensitive transcriptional repressor IMS PF00817.15 CCF34847.1 - 1.1e-42 145.4 0.1 1.9e-42 144.5 0.1 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 CCF34847.1 - 2.5e-16 59.7 0.6 5.9e-16 58.5 0.0 1.9 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 CCF34847.1 - 0.00049 19.9 0.0 0.0013 18.6 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif Arg_repressor PF01316.16 CCF34847.1 - 0.34 10.4 3.1 0.75 9.3 1.4 2.1 2 0 0 2 2 2 0 Arginine repressor, DNA binding domain RGS PF00615.14 CCF34848.1 - 0.00021 21.3 0.0 0.0011 19.0 0.0 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain RNA_polI_A14 PF08203.6 CCF34848.1 - 0.15 12.3 0.0 0.35 11.1 0.0 1.6 1 0 0 1 1 1 0 Yeast RNA polymerase I subunit RPA14 zf-RING_2 PF13639.1 CCF34849.1 - 3.5e-13 49.1 3.9 7.9e-11 41.6 0.5 2.1 2 0 0 2 2 2 2 Ring finger domain zf-rbx1 PF12678.2 CCF34849.1 - 3e-11 43.2 3.4 7.8e-11 41.9 2.4 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 CCF34849.1 - 1.9e-09 37.0 1.5 6.3e-08 32.1 0.2 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF34849.1 - 2.4e-08 33.4 3.0 1.3e-07 31.1 2.1 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF34849.1 - 1.1e-07 31.4 1.9 1.3e-06 28.0 0.3 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CCF34849.1 - 6.2e-07 29.3 4.8 2.5e-06 27.3 0.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.1 CCF34849.1 - 1e-05 24.9 0.3 2e-05 24.0 0.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.1 CCF34849.1 - 0.00012 21.7 2.1 0.15 11.8 0.0 3.1 3 0 0 3 3 3 1 RING-type zinc-finger zf-Apc11 PF12861.2 CCF34849.1 - 0.00025 20.8 0.8 0.00057 19.6 0.1 1.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.9 CCF34849.1 - 0.0018 17.7 0.5 0.0018 17.7 0.4 1.8 2 0 0 2 2 2 1 P-11 zinc finger RINGv PF12906.2 CCF34849.1 - 0.0027 17.6 6.4 0.0034 17.3 1.9 2.1 2 0 0 2 2 2 1 RING-variant domain zf-RING_6 PF14835.1 CCF34849.1 - 0.0038 16.9 0.2 0.007 16.1 0.1 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Rtf2 PF04641.7 CCF34849.1 - 0.0057 15.8 0.0 0.0075 15.4 0.0 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_4 PF14570.1 CCF34849.1 - 0.04 13.5 2.0 0.049 13.2 0.4 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.6 CCF34849.1 - 0.044 13.8 2.7 0.088 12.8 1.9 1.5 1 0 0 1 1 1 0 RING-like domain zf-C3HC4_4 PF15227.1 CCF34849.1 - 0.078 12.8 8.7 0.5 10.2 2.0 2.7 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING Rad50_zn_hook PF04423.9 CCF34849.1 - 0.081 12.4 0.2 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 Rad50 zinc hook motif C1_1 PF00130.17 CCF34849.1 - 3 7.6 6.5 7.2 6.4 1.6 2.7 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FANCL_C PF11793.3 CCF34849.1 - 6.9 6.7 6.6 29 4.7 2.9 2.6 2 1 0 2 2 2 0 FANCL C-terminal domain Ribosomal_L37ae PF01780.14 CCF34850.1 - 3.5e-40 135.7 8.6 3.8e-40 135.6 6.0 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.2 CCF34850.1 - 0.0028 17.4 3.6 0.0042 16.8 2.5 1.3 1 0 0 1 1 1 1 Transposase zinc-ribbon domain A2L_zn_ribbon PF08792.5 CCF34850.1 - 0.0052 16.1 3.7 0.43 10.0 0.0 2.1 2 0 0 2 2 2 2 A2L zinc ribbon domain Sgf11 PF08209.6 CCF34850.1 - 0.089 12.1 0.3 1 8.7 0.0 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Thymidylat_synt PF00303.14 CCF34850.1 - 0.11 11.4 0.0 0.13 11.2 0.0 1.1 1 0 0 1 1 1 0 Thymidylate synthase C1_1 PF00130.17 CCF34850.1 - 0.13 12.0 2.5 0.19 11.4 1.7 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Elf1 PF05129.8 CCF34850.1 - 0.14 11.8 2.3 0.25 11.0 1.6 1.5 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like OrfB_Zn_ribbon PF07282.6 CCF34850.1 - 0.15 11.7 1.8 0.21 11.2 1.3 1.3 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Zn-ribbon_8 PF09723.5 CCF34850.1 - 0.19 11.7 2.5 0.38 10.7 0.1 2.2 2 0 0 2 2 2 0 Zinc ribbon domain Rep_fac-A_C PF08646.5 CCF34850.1 - 0.52 10.0 2.4 0.84 9.3 1.7 1.4 1 1 0 1 1 1 0 Replication factor-A C terminal domain CarbpepA_inh PF02977.10 CCF34850.1 - 0.53 9.9 4.3 2.3 7.8 3.0 2.0 1 1 0 1 1 1 0 Carboxypeptidase A inhibitor zf-C2H2 PF00096.21 CCF34850.1 - 3.5 8.1 5.8 6.7 7.2 0.8 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type Saccharop_dh PF03435.13 CCF34851.1 - 6.6e-17 61.5 0.0 2.8e-16 59.5 0.0 1.8 2 0 0 2 2 2 1 Saccharopine dehydrogenase Semialdhyde_dh PF01118.19 CCF34851.1 - 0.06 13.6 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 CCF34851.1 - 0.08 12.8 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus A_deaminase PF00962.17 CCF34852.1 - 1.2e-07 30.9 0.3 4.2e-07 29.1 0.2 1.8 1 1 0 1 1 1 1 Adenosine/AMP deaminase Cullin PF00888.17 CCF34852.1 - 0.078 11.5 0.2 0.1 11.1 0.1 1.2 1 0 0 1 1 1 0 Cullin family DHDPS PF00701.17 CCF34853.1 - 2.8e-42 144.2 0.0 3.2e-42 144.1 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Sugar_tr PF00083.19 CCF34854.1 - 1.6e-93 313.7 20.4 1.9e-93 313.5 14.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF34854.1 - 1.6e-20 73.1 16.3 1.6e-20 73.1 11.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF791 PF05631.9 CCF34854.1 - 0.00065 18.5 0.1 0.00065 18.5 0.1 2.7 3 1 1 4 4 4 1 Protein of unknown function (DUF791) Fungal_trans_2 PF11951.3 CCF34855.1 - 1.9e-52 178.1 0.5 2.1e-52 178.0 0.4 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pec_lyase_C PF00544.14 CCF34856.1 - 5.7e-44 149.9 3.2 8e-44 149.5 2.2 1.2 1 0 0 1 1 1 1 Pectate lyase Glycos_transf_3 PF00591.16 CCF34858.1 - 8e-64 215.4 0.0 1.2e-63 214.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.12 CCF34858.1 - 7e-09 35.1 0.1 2.5e-08 33.3 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase family, helical bundle domain HTH_psq PF05225.11 CCF34858.1 - 0.031 13.8 0.7 0.45 10.1 0.0 2.4 2 0 0 2 2 2 0 helix-turn-helix, Psq domain DAGK_cat PF00781.19 CCF34859.1 - 1.2e-23 82.9 0.0 2.2e-23 82.1 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain PRKCSH-like PF12999.2 CCF34859.1 - 0.025 14.1 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 Glucosidase II beta subunit-like Nop52 PF05997.7 CCF34860.1 - 4.3e-15 55.7 0.0 5.6e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 Nucleolar protein,Nop52 Pectinesterase PF01095.14 CCF34861.1 - 7e-146 484.4 59.6 3.7e-45 153.7 3.6 6.2 6 0 0 6 6 6 4 Pectinesterase MFS_1 PF07690.11 CCF34862.1 - 4.3e-08 32.2 32.5 3.2e-07 29.4 22.8 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.11 CCF34863.1 - 1.2e-38 132.8 57.1 3.3e-38 131.3 38.9 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily HET PF06985.6 CCF34864.1 - 2.7e-38 131.2 0.4 4.9e-38 130.4 0.3 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Herpes_LMP2 PF07415.6 CCF34866.1 - 0.31 9.5 5.1 0.33 9.4 3.5 1.1 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein NO_synthase PF02898.10 CCF34867.1 - 2.9e-73 246.7 0.0 5.9e-73 245.6 0.0 1.4 1 1 0 1 1 1 1 Nitric oxide synthase, oxygenase domain Flavodoxin_1 PF00258.20 CCF34867.1 - 2.6e-09 37.2 0.0 7.4e-09 35.7 0.0 1.8 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.15 CCF34867.1 - 0.00021 20.7 0.0 0.0047 16.4 0.0 2.2 1 1 1 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.16 CCF34867.1 - 0.0017 18.9 0.0 0.0041 17.6 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Cu-oxidase_3 PF07732.10 CCF34868.1 - 2.4e-44 149.8 0.7 2.4e-44 149.8 0.5 2.6 2 1 1 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.17 CCF34868.1 - 3.4e-33 114.8 0.0 1.1e-32 113.0 0.0 1.8 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 CCF34868.1 - 1.3e-05 24.7 1.7 0.74 9.3 0.0 3.8 3 1 0 3 3 3 2 Multicopper oxidase MFS_1 PF07690.11 CCF34870.1 - 6.6e-26 90.8 20.6 9e-26 90.4 14.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Exo_endo_phos PF03372.18 CCF34871.1 - 1.4e-13 51.3 0.0 3.5e-13 50.0 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DCP1 PF06058.8 CCF34872.1 - 2.7e-17 62.9 0.0 4e-17 62.3 0.0 1.2 1 0 0 1 1 1 1 Dcp1-like decapping family TraV PF09676.5 CCF34874.1 - 0.21 12.2 3.4 0.24 12.1 2.4 1.1 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) Nramp PF01566.13 CCF34875.1 - 3e-16 59.1 0.2 3e-16 59.1 0.1 1.9 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein Ribonuc_L-PSP PF01042.16 CCF34876.1 - 2.6e-21 75.6 0.0 3e-21 75.4 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF1035 PF06281.7 CCF34877.1 - 0.11 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1035) Zn_clus PF00172.13 CCF34878.1 - 4.9e-08 32.7 13.5 7.5e-08 32.1 9.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF34878.1 - 1.2e-07 30.8 0.0 1.7e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DSBA PF01323.15 CCF34878.1 - 0.011 15.2 0.0 0.021 14.4 0.0 1.4 1 0 0 1 1 1 0 DSBA-like thioredoxin domain OrfB_Zn_ribbon PF07282.6 CCF34878.1 - 0.73 9.5 7.4 1.4 8.6 5.1 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Sugar_tr PF00083.19 CCF34880.1 - 1.7e-63 214.7 31.6 2.2e-63 214.4 21.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF34880.1 - 1.7e-21 76.3 34.0 1.7e-21 76.3 23.5 2.3 1 1 2 3 3 3 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF34880.1 - 2.9 6.1 41.2 0.068 11.5 9.7 3.3 2 2 1 3 3 3 0 MFS/sugar transport protein AA_permease_C PF13906.1 CCF34880.1 - 3.7 7.5 13.6 0.12 12.2 0.4 3.5 3 0 0 3 3 3 0 C-terminus of AA_permease Abhydrolase_3 PF07859.8 CCF34881.1 - 3.6e-17 62.6 0.0 3.2e-11 43.2 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF34881.1 - 1e-11 44.8 0.0 1.5e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF34881.1 - 2.1e-11 43.4 0.0 1.6e-07 30.8 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 CCF34881.1 - 2.7e-09 37.2 0.2 3.5e-09 36.8 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family COesterase PF00135.23 CCF34881.1 - 3.2e-06 26.1 0.1 1.9e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 Carboxylesterase family Peptidase_S15 PF02129.13 CCF34881.1 - 6.4e-05 22.5 0.0 0.00052 19.5 0.0 2.1 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.11 CCF34881.1 - 0.00033 20.1 0.0 0.075 12.4 0.0 2.7 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase DLH PF01738.13 CCF34881.1 - 0.0033 16.7 0.0 0.017 14.3 0.0 2.0 2 1 0 2 2 2 1 Dienelactone hydrolase family Esterase_phd PF10503.4 CCF34881.1 - 0.0038 16.5 0.1 5.9 6.0 0.0 3.0 3 0 0 3 3 3 1 Esterase PHB depolymerase AXE1 PF05448.7 CCF34881.1 - 0.047 12.1 0.0 0.24 9.8 0.0 1.9 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) DUF1472 PF07339.7 CCF34882.1 - 0.11 12.8 0.7 0.33 11.2 0.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1472) Glyco_hydro_43 PF04616.9 CCF34883.1 - 5.5e-73 245.5 2.5 6.9e-73 245.2 1.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.15 CCF34883.1 - 0.033 13.5 1.7 0.033 13.5 0.0 1.8 2 0 0 2 2 2 0 Glycosyl hydrolases family 32 N-terminal domain DUF4613 PF15390.1 CCF34886.1 - 0.002 16.4 4.8 0.002 16.4 3.3 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4613) NPV_P10 PF05531.7 CCF34886.1 - 0.029 14.6 8.8 0.044 14.0 0.4 2.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Spc7 PF08317.6 CCF34886.1 - 0.037 12.6 19.9 0.032 12.9 3.8 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein IF2_N PF04760.10 CCF34886.1 - 0.067 12.8 2.6 0.15 11.7 0.5 2.4 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region AAA_13 PF13166.1 CCF34886.1 - 0.14 10.6 15.6 0.25 9.7 10.8 1.6 1 1 0 1 1 1 0 AAA domain DUF4140 PF13600.1 CCF34886.1 - 0.28 11.6 24.7 0.062 13.7 1.6 3.2 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Reo_sigmaC PF04582.7 CCF34886.1 - 0.36 9.9 3.5 1.2 8.2 0.1 2.5 2 1 1 3 3 3 0 Reovirus sigma C capsid protein CorA PF01544.13 CCF34886.1 - 0.56 9.1 5.8 0.69 8.8 3.7 1.3 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF3037 PF11236.3 CCF34886.1 - 0.59 10.1 3.5 0.53 10.3 0.1 2.3 3 0 0 3 3 2 0 Protein of unknown function (DUF3037) Laminin_II PF06009.7 CCF34886.1 - 0.76 9.5 17.0 0.24 11.1 1.3 3.0 3 0 0 3 3 3 0 Laminin Domain II TBPIP PF07106.8 CCF34886.1 - 0.85 9.1 19.5 0.97 8.9 4.3 2.5 1 1 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DASH_Dam1 PF08653.5 CCF34886.1 - 1.3 8.8 4.5 7.1 6.4 0.0 3.6 3 2 1 4 4 4 0 DASH complex subunit Dam1 Spc24 PF08286.6 CCF34886.1 - 1.4 8.6 19.3 0.055 13.1 2.8 3.5 3 1 0 3 3 3 0 Spc24 subunit of Ndc80 ADIP PF11559.3 CCF34886.1 - 1.5 8.7 25.7 0.24 11.3 5.9 3.0 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding TMF_TATA_bd PF12325.3 CCF34886.1 - 1.6 8.4 21.2 0.86 9.3 3.1 3.2 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.3 CCF34886.1 - 1.6 8.5 31.9 1.9 8.3 6.2 4.1 3 2 1 4 4 4 0 TATA element modulatory factor 1 DNA binding DUF342 PF03961.8 CCF34886.1 - 2.1 6.6 16.7 1.5 7.1 2.9 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF342) Lge1 PF11488.3 CCF34886.1 - 2.7 8.2 12.9 6.4 7.0 1.1 3.3 2 1 1 3 3 3 0 Transcriptional regulatory protein LGE1 IncA PF04156.9 CCF34886.1 - 3.1 7.3 32.1 0.74 9.3 7.8 3.0 1 1 1 3 3 3 0 IncA protein ATG16 PF08614.6 CCF34886.1 - 3.1 7.5 27.9 1.7 8.4 2.9 3.2 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) BLOC1_2 PF10046.4 CCF34886.1 - 3.6 7.7 13.9 0.08 13.0 1.8 3.0 3 1 0 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Bacillus_HBL PF05791.6 CCF34886.1 - 3.7 6.8 9.5 2.5 7.4 1.2 2.3 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) IFT20 PF14931.1 CCF34886.1 - 3.7 7.4 14.5 0.56 10.1 5.4 2.7 2 1 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 FemAB PF02388.11 CCF34886.1 - 4.3 5.8 19.5 0.028 13.1 2.6 2.3 1 1 1 2 2 2 0 FemAB family Osmo_CC PF08946.5 CCF34886.1 - 4.9 7.2 14.2 5.9 6.9 0.1 4.6 4 1 1 5 5 4 0 Osmosensory transporter coiled coil Occludin_ELL PF07303.8 CCF34886.1 - 6.2 7.6 13.7 4.3 8.1 2.5 3.4 2 1 0 3 3 3 0 Occludin homology domain DUF720 PF05302.6 CCF34886.1 - 6.4 6.5 9.0 0.35 10.6 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF720) Cob_adeno_trans PF01923.13 CCF34886.1 - 7.6 6.2 11.2 0.33 10.7 0.8 2.5 2 1 1 3 3 2 0 Cobalamin adenosyltransferase Uds1 PF15456.1 CCF34886.1 - 9.8 6.1 22.9 1.7 8.6 1.6 3.0 3 0 0 3 3 3 0 Up-regulated During Septation Ribosomal_L37e PF01907.14 CCF34887.1 - 1.5e-27 95.1 13.2 2.2e-27 94.5 9.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.2 CCF34887.1 - 0.0025 17.5 1.7 0.0038 17.0 1.2 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.1 CCF34887.1 - 0.11 11.7 2.1 0.4 9.9 1.5 1.8 1 1 2 3 3 3 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 CCF34887.1 - 0.4 10.2 4.0 8.7 5.9 0.6 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-C3HC4 PF00097.20 CCF34887.1 - 2.7 7.7 6.0 4.5 7.0 4.2 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Ribosomal_S14 PF00253.16 CCF34887.1 - 6.8 6.1 11.1 4.1 6.8 0.6 2.5 1 1 1 2 2 2 0 Ribosomal protein S14p/S29e DUF2348 PF09807.4 CCF34888.1 - 4.3e-11 42.3 0.0 5.8e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2348) KaiC PF06745.8 CCF34888.1 - 0.0028 16.7 0.0 0.0035 16.4 0.0 1.1 1 0 0 1 1 1 1 KaiC MFS_1 PF07690.11 CCF34890.1 - 2e-37 128.7 27.3 2e-37 128.7 18.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF34890.1 - 1.4e-10 40.3 11.6 1.4e-10 40.3 8.1 2.4 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.8 CCF34890.1 - 4.6e-06 25.1 4.8 1e-05 23.9 3.3 1.5 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.8 CCF34890.1 - 4.6e-05 21.7 0.9 4.6e-05 21.7 0.6 2.1 2 0 0 2 2 2 1 Transmembrane secretion effector ATG22 PF11700.3 CCF34890.1 - 0.047 12.1 20.0 0.0056 15.2 6.5 2.4 2 0 0 2 2 2 0 Vacuole effluxer Atg22 like Aminotran_3 PF00202.16 CCF34891.1 - 1.6e-49 168.5 0.1 2.4e-27 95.7 0.0 2.0 2 0 0 2 2 2 2 Aminotransferase class-III Asparaginase_2 PF01112.13 CCF34892.1 - 1.6e-85 286.6 1.1 1.9e-85 286.4 0.8 1.0 1 0 0 1 1 1 1 Asparaginase Bac_rhamnosid PF05592.6 CCF34894.1 - 7.7e-22 77.1 0.0 9.7e-21 73.5 0.0 2.4 1 1 0 1 1 1 1 Bacterial alpha-L-rhamnosidase DUF608 PF04685.8 CCF34894.1 - 0.025 13.2 0.0 0.039 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF608 Cytomega_UL20A PF05984.7 CCF34895.1 - 0.12 12.6 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 Cytomegalovirus UL20A protein PFU PF09070.6 CCF34897.1 - 1e-43 148.0 0.1 2.1e-43 147.0 0.1 1.5 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) PUL PF08324.6 CCF34897.1 - 4.1e-41 140.5 0.0 6.7e-41 139.8 0.0 1.3 1 0 0 1 1 1 1 PUL domain WD40 PF00400.27 CCF34897.1 - 2.6e-38 128.5 7.6 8e-07 28.7 0.0 7.7 8 0 0 8 8 8 7 WD domain, G-beta repeat BBS2_Mid PF14783.1 CCF34897.1 - 0.05 13.3 0.0 3.6 7.3 0.0 3.1 2 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.27 CCF34898.1 - 4e-35 118.4 4.2 3.6e-11 42.4 0.0 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat Glyco_hydro_16 PF00722.16 CCF34901.1 - 8.9e-17 60.9 0.0 1.5e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Syndecan PF01034.15 CCF34904.1 - 0.0003 20.3 0.1 0.00061 19.3 0.0 1.4 1 0 0 1 1 1 1 Syndecan domain EphA2_TM PF14575.1 CCF34904.1 - 0.02 15.2 0.0 0.047 14.0 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SKG6 PF08693.5 CCF34904.1 - 0.21 10.9 4.6 0.35 10.2 3.2 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Pyridoxal_deC PF00282.14 CCF34910.1 - 4.2e-16 58.3 0.0 6.3e-16 57.7 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.14 CCF34910.1 - 1.9e-05 23.6 0.0 5.7e-05 22.0 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 CCF34910.1 - 0.086 11.8 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family DUF963 PF06131.6 CCF34911.1 - 0.17 11.2 4.3 0.28 10.4 3.0 1.4 1 0 0 1 1 1 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) AICARFT_IMPCHas PF01808.13 CCF34912.1 - 3.2e-113 377.9 0.0 4.1e-113 377.6 0.0 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.17 CCF34912.1 - 4.3e-13 49.0 0.1 9.3e-13 47.9 0.0 1.6 1 0 0 1 1 1 1 MGS-like domain zf-H2C2_2 PF13465.1 CCF34913.1 - 1.9e-26 90.9 32.6 1.9e-08 34.1 0.0 7.2 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2 PF00096.21 CCF34913.1 - 1.1e-15 56.9 47.5 0.00035 20.7 0.3 8.5 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF34913.1 - 7.7e-12 44.6 39.0 0.048 14.0 0.3 8.7 8 0 0 8 8 8 6 C2H2-type zinc finger zf-C2H2_6 PF13912.1 CCF34913.1 - 2.9e-06 26.9 24.5 0.0061 16.4 0.1 6.1 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CCF34913.1 - 0.0023 18.0 32.0 0.12 12.5 2.4 6.7 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding BRCT PF00533.21 CCF34915.1 - 0.043 13.9 0.0 0.13 12.4 0.0 1.9 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 CCF34915.1 - 0.063 13.1 0.5 0.16 11.8 0.2 1.8 2 0 0 2 2 2 0 twin BRCT domain AT_hook PF02178.14 CCF34915.1 - 0.16 11.7 11.9 0.36 10.6 0.3 4.2 3 0 0 3 3 3 0 AT hook motif Glyco_hyd_65N_2 PF14498.1 CCF34916.1 - 1.4e-11 44.5 0.0 1.6e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain CVNH PF08881.5 CCF34917.1 - 8.2e-14 51.7 0.2 5.7e-13 48.9 0.1 2.0 1 1 0 1 1 1 1 CVNH domain zf-TFIIIC PF12660.2 CCF34918.1 - 6e-10 38.9 1.8 9.7e-10 38.2 1.2 1.3 1 0 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex Adaptin_N PF01602.15 CCF34920.1 - 1.2e-132 442.8 9.7 1.6e-132 442.5 6.7 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 CCF34920.1 - 4.1e-18 65.8 1.7 2e-17 63.6 0.0 2.7 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 CCF34920.1 - 1.7e-16 60.2 4.7 4.2e-10 39.7 0.2 4.3 3 1 2 5 5 5 4 HEAT repeats HEAT PF02985.17 CCF34920.1 - 1.2e-11 43.6 3.2 0.00045 20.0 0.0 4.8 5 0 0 5 5 5 3 HEAT repeat CLASP_N PF12348.3 CCF34920.1 - 1.7e-05 24.2 0.2 0.018 14.3 0.0 2.8 2 0 0 2 2 2 2 CLASP N terminal HEAT_EZ PF13513.1 CCF34920.1 - 1.7e-05 25.1 3.5 0.76 10.3 0.0 5.8 5 1 1 6 6 6 1 HEAT-like repeat Atx10homo_assoc PF09759.4 CCF34920.1 - 9.8e-05 22.0 0.1 0.3 10.8 0.0 4.5 4 1 0 4 4 4 1 Spinocerebellar ataxia type 10 protein domain Arm PF00514.18 CCF34920.1 - 0.0055 16.4 0.7 2.8 7.8 0.0 4.6 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat DUF2435 PF10363.4 CCF34920.1 - 0.047 13.5 1.4 1.2 9.0 0.0 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF2435) DUF1077 PF06417.7 CCF34921.1 - 3.9e-54 181.3 4.2 4.9e-54 181.0 2.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) HET PF06985.6 CCF34923.1 - 6.2e-27 94.4 0.0 9.3e-27 93.8 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) FAM70 PF14967.1 CCF34924.1 - 9.6 5.2 10.7 11 5.0 7.4 1.2 1 0 0 1 1 1 0 FAM70 protein SH3BGR PF04908.10 CCF34925.1 - 1.9e-05 24.5 0.0 6.4e-05 22.8 0.0 2.0 1 1 1 2 2 2 1 SH3-binding, glutamic acid-rich protein DUF4551 PF15087.1 CCF34925.1 - 1.4 7.2 4.6 1.8 6.8 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Lipase_GDSL PF00657.17 CCF34927.1 - 1.7e-13 50.9 0.0 2.4e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.1 CCF34927.1 - 2e-13 50.8 0.1 2.7e-13 50.4 0.1 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL_3 PF14606.1 CCF34927.1 - 0.00022 21.0 0.0 0.00032 20.4 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Rax2 PF12768.2 CCF34929.1 - 0.012 14.8 0.0 0.016 14.4 0.0 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF1168 PF06658.7 CCF34930.1 - 0.032 13.7 0.2 0.054 13.0 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) His_Phos_1 PF00300.17 CCF34931.1 - 8e-32 110.5 0.7 1.2e-31 109.9 0.0 1.6 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.17 CCF34931.1 - 6.6e-05 22.3 0.0 9.9e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Transket_pyr PF02779.19 CCF34932.1 - 2.9e-62 209.2 0.0 5.4e-62 208.4 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 CCF34932.1 - 2.8e-55 187.1 0.0 3.9e-55 186.7 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component WW PF00397.21 CCF34933.1 - 4.8e-07 29.5 0.3 9.8e-07 28.5 0.2 1.6 1 0 0 1 1 1 1 WW domain Pga1 PF10333.4 CCF34934.1 - 0.0056 16.3 0.3 0.015 14.9 0.0 1.9 2 1 0 2 2 2 1 GPI-Mannosyltransferase II co-activator PAP2 PF01569.16 CCF34934.1 - 0.032 13.9 0.7 0.062 12.9 0.0 1.8 2 0 0 2 2 2 0 PAP2 superfamily Tubulin PF00091.20 CCF34935.1 - 6.2e-69 232.1 0.0 8.8e-69 231.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 CCF34935.1 - 1.5e-48 164.0 0.1 2.5e-48 163.2 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 CCF34935.1 - 0.0028 17.1 0.0 0.0064 15.9 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain p450 PF00067.17 CCF34936.1 - 2.3e-30 105.5 0.0 2.9e-30 105.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DIT1_PvcA PF05141.7 CCF34937.1 - 6.8e-99 330.6 0.0 8.6e-99 330.3 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein Pertussis_S2S3 PF02918.10 CCF34937.1 - 0.071 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Pertussis toxin, subunit 2 and 3, C-terminal domain GMC_oxred_N PF00732.14 CCF34938.1 - 5.3e-56 189.9 0.0 6.9e-56 189.5 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF34938.1 - 8.3e-39 133.1 0.2 1.4e-38 132.4 0.1 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 CCF34938.1 - 4.5e-05 22.5 0.0 0.00089 18.2 0.0 2.5 3 0 0 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CCF34938.1 - 5.5e-05 22.1 0.1 0.021 13.7 0.2 2.2 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.7 CCF34938.1 - 0.00033 19.6 0.1 0.00049 19.1 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.9 CCF34938.1 - 0.00043 20.2 0.0 0.00077 19.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF34938.1 - 0.00048 20.0 0.5 0.0012 18.7 0.4 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 CCF34938.1 - 0.00052 19.1 0.2 0.0016 17.5 0.1 1.7 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.1 CCF34938.1 - 0.011 15.7 0.3 3.3 7.7 0.3 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF34938.1 - 0.032 13.9 0.6 0.062 13.0 0.1 1.8 2 1 0 2 2 2 0 FAD-NAD(P)-binding HI0933_like PF03486.9 CCF34938.1 - 0.047 12.1 0.1 0.072 11.5 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Trp_halogenase PF04820.9 CCF34938.1 - 0.056 12.0 0.3 0.1 11.2 0.2 1.4 1 0 0 1 1 1 0 Tryptophan halogenase WSC PF01822.14 CCF34940.1 - 5.3e-10 39.0 1.8 5.3e-10 39.0 1.2 3.1 2 1 0 2 2 2 1 WSC domain TFIIA PF03153.8 CCF34940.1 - 4.6 7.0 15.1 7 6.4 10.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CPSase_L_D2 PF02786.12 CCF34941.1 - 4.4e-112 372.4 0.2 1.6e-83 279.1 0.0 2.2 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.17 CCF34941.1 - 5.2e-44 148.9 0.0 1.4e-43 147.4 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 CCF34941.1 - 5.6e-44 149.9 0.0 1.1e-43 148.8 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.14 CCF34941.1 - 4.7e-42 142.6 0.2 1.7e-41 140.8 0.1 2.1 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain CPSase_L_chain PF00289.17 CCF34941.1 - 2.9e-41 140.0 0.1 6.3e-20 71.3 0.0 3.1 3 0 0 3 3 3 2 Carbamoyl-phosphate synthase L chain, N-terminal domain ATP-grasp_4 PF13535.1 CCF34941.1 - 1.3e-35 122.8 0.2 2e-22 79.8 0.1 2.8 3 0 0 3 3 3 2 ATP-grasp domain ATPgrasp_Ter PF15632.1 CCF34941.1 - 1.7e-23 82.9 0.0 1.4e-11 43.7 0.0 3.9 3 1 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon MGS PF02142.17 CCF34941.1 - 3.8e-22 78.0 0.0 1.6e-21 76.0 0.0 2.2 2 0 0 2 2 2 1 MGS-like domain ATP-grasp PF02222.17 CCF34941.1 - 9.1e-16 57.6 0.1 1.7e-07 30.7 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.8 CCF34941.1 - 1.3e-15 57.4 0.7 1.1e-07 31.4 0.1 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus OTCace_N PF02729.16 CCF34941.1 - 2.1e-14 53.3 0.1 4.8e-14 52.2 0.1 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain ATP-grasp_3 PF02655.9 CCF34941.1 - 1.2e-06 28.4 0.4 0.017 14.9 0.1 2.8 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.8 CCF34941.1 - 1.5e-06 27.8 0.1 4.7e-05 22.9 0.0 2.7 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.19 CCF34941.1 - 0.0014 18.0 0.0 0.0032 16.9 0.0 1.5 1 0 0 1 1 1 1 DJ-1/PfpI family GARS_A PF01071.14 CCF34941.1 - 0.019 14.5 0.4 7.8 6.0 0.0 2.9 3 0 0 3 3 3 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Glyco_hydro_17 PF00332.13 CCF34942.1 - 1.7e-07 30.6 4.1 0.0034 16.4 0.2 2.3 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 DUF4083 PF13314.1 CCF34942.1 - 0.18 11.6 0.1 0.31 10.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) Ribosomal_S24e PF01282.14 CCF34943.1 - 2.7e-34 116.8 0.0 4.1e-34 116.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e RRXRR PF14239.1 CCF34943.1 - 0.022 14.1 0.8 0.024 14.0 0.6 1.2 1 0 0 1 1 1 0 RRXRR protein Methyltransf_16 PF10294.4 CCF34944.1 - 2.4e-20 72.7 0.0 3.7e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 CCF34944.1 - 1.2e-06 29.0 0.0 2.6e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF34944.1 - 6.3e-05 22.4 0.0 0.0001 21.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.11 CCF34944.1 - 0.00049 19.7 0.0 0.00072 19.1 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein DUF938 PF06080.7 CCF34944.1 - 0.0019 17.7 0.0 0.003 17.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_3 PF01596.12 CCF34944.1 - 0.002 17.2 0.0 0.0029 16.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase PCMT PF01135.14 CCF34944.1 - 0.003 17.1 0.2 0.012 15.1 0.1 2.0 1 1 1 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.1 CCF34944.1 - 0.0053 16.4 0.0 0.0081 15.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 CCF34944.1 - 0.0083 15.2 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.7 CCF34944.1 - 0.011 16.1 0.1 0.023 15.1 0.1 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 CCF34944.1 - 0.023 14.3 0.1 0.043 13.4 0.1 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 CCF34944.1 - 0.095 12.7 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Whi5 PF08528.6 CCF34946.1 - 3.3e-12 45.6 0.2 5.8e-12 44.8 0.2 1.4 1 0 0 1 1 1 1 Whi5 like eIF_4EBP PF05456.6 CCF34946.1 - 0.35 10.5 4.0 0.6 9.8 0.3 2.6 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) HEM4 PF02602.10 CCF34947.1 - 3.1e-37 128.0 0.0 4.2e-37 127.6 0.0 1.1 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Cupin_2 PF07883.6 CCF34947.1 - 0.093 12.2 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Cupin domain Evr1_Alr PF04777.8 CCF34948.1 - 3.1e-30 103.9 1.0 1.9e-29 101.3 0.5 1.9 2 0 0 2 2 2 1 Erv1 / Alr family Zw10 PF06248.8 CCF34949.1 - 0.034 12.3 0.4 0.062 11.4 0.3 1.5 1 1 1 2 2 2 0 Centromere/kinetochore Zw10 InvH PF04741.7 CCF34949.1 - 0.11 12.4 0.2 0.19 11.5 0.1 1.4 1 1 0 1 1 1 0 InvH outer membrane lipoprotein HNH_2 PF13391.1 CCF34950.1 - 0.02 14.6 0.0 0.048 13.4 0.0 1.7 1 1 0 1 1 1 0 HNH endonuclease Syja_N PF02383.13 CCF34951.1 - 1.1e-86 290.4 0.0 1.4e-86 290.1 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain Glyco_hydro_76 PF03663.9 CCF34952.1 - 6.9e-120 400.8 11.9 8.4e-120 400.5 8.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 BCS1_N PF08740.6 CCF34953.1 - 1.2e-29 103.2 2.1 3.2e-29 101.9 0.0 2.1 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.24 CCF34953.1 - 8.4e-18 64.8 0.0 6.8e-17 61.9 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 CCF34953.1 - 4.1e-05 22.7 0.0 6.8e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 CCF34953.1 - 0.00096 19.9 0.3 0.0043 17.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_11 PF13086.1 CCF34953.1 - 0.0012 18.5 0.0 0.0029 17.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CCF34953.1 - 0.025 14.3 0.0 0.059 13.1 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain HNH_3 PF13392.1 CCF34953.1 - 0.028 13.8 0.0 0.071 12.5 0.0 1.6 1 0 0 1 1 1 0 HNH endonuclease AAA_25 PF13481.1 CCF34953.1 - 0.028 13.8 0.0 0.07 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CCF34953.1 - 0.038 13.9 0.5 0.15 12.0 0.4 2.2 1 1 0 1 1 1 0 AAA ATPase domain KaiC PF06745.8 CCF34953.1 - 0.072 12.1 0.0 0.22 10.6 0.0 1.8 2 0 0 2 2 2 0 KaiC p450 PF00067.17 CCF34954.1 - 2.4e-78 263.7 0.0 3.1e-78 263.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Glyoxalase PF00903.20 CCF34955.1 - 7.1e-11 42.1 0.0 1.2e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 CCF34955.1 - 3e-07 31.0 0.0 4.8e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain CppA_N PF14506.1 CCF34955.1 - 0.00064 19.3 0.0 0.001 18.7 0.0 1.3 1 0 0 1 1 1 1 CppA N-terminal ABC2_membrane PF01061.19 CCF34956.1 - 9.5e-100 332.0 54.8 1.5e-50 171.2 12.5 3.4 4 0 0 4 4 4 2 ABC-2 type transporter PDR_CDR PF06422.7 CCF34956.1 - 3.8e-36 122.8 4.8 5.3e-32 109.5 0.0 3.2 3 0 0 3 3 2 2 CDR ABC transporter ABC_tran PF00005.22 CCF34956.1 - 8.4e-35 120.0 0.0 3.7e-16 59.6 0.0 3.4 3 0 0 3 3 3 2 ABC transporter ABC_trans_N PF14510.1 CCF34956.1 - 3.7e-22 78.2 0.0 1e-21 76.8 0.0 1.8 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_16 PF13191.1 CCF34956.1 - 2.4e-07 30.9 0.1 3.4e-05 23.8 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.1 CCF34956.1 - 3.6e-07 29.7 0.0 0.00095 18.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 CCF34956.1 - 1e-05 24.8 0.0 0.00084 18.5 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_33 PF13671.1 CCF34956.1 - 1.3e-05 25.0 0.0 0.033 14.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 CCF34956.1 - 8.5e-05 22.0 0.6 0.022 14.3 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain cobW PF02492.14 CCF34956.1 - 0.00015 21.3 0.8 0.0035 16.8 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.1 CCF34956.1 - 0.00073 20.3 0.0 0.15 12.8 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CCF34956.1 - 0.00084 19.4 0.1 0.53 10.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.1 CCF34956.1 - 0.0012 18.8 0.1 1.4 8.7 0.0 2.9 4 0 0 4 4 2 1 AAA domain AAA_19 PF13245.1 CCF34956.1 - 0.0045 16.7 0.1 2.7 7.8 0.0 2.6 2 0 0 2 2 2 1 Part of AAA domain SMC_N PF02463.14 CCF34956.1 - 0.0046 16.2 0.0 2 7.6 0.0 3.5 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain NACHT PF05729.7 CCF34956.1 - 0.008 15.8 0.0 2 8.0 0.0 2.6 2 0 0 2 2 2 1 NACHT domain ABC2_membrane_3 PF12698.2 CCF34956.1 - 0.032 13.2 46.9 0.8 8.6 13.4 4.0 3 2 0 3 3 3 0 ABC-2 family transporter protein AAA_18 PF13238.1 CCF34956.1 - 0.036 14.3 0.1 1.2 9.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.1 CCF34956.1 - 0.047 13.6 0.1 0.66 9.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain UPF0079 PF02367.12 CCF34956.1 - 0.071 12.7 0.5 2.9 7.5 0.1 2.6 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Miro PF08477.8 CCF34956.1 - 0.073 13.5 0.0 13 6.2 0.0 2.5 2 0 0 2 2 2 0 Miro-like protein AAA PF00004.24 CCF34956.1 - 0.074 13.2 0.1 9.5 6.4 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 CCF34956.1 - 0.076 12.4 0.1 5.3 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain AAA_23 PF13476.1 CCF34956.1 - 0.11 12.8 0.1 0.41 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF3357 PF11837.3 CCF34956.1 - 0.44 10.4 0.0 0.44 10.4 0.0 2.7 4 0 0 4 4 1 0 Domain of unknown function (DUF3357) SNF2_N PF00176.18 CCF34961.1 - 2.3e-07 29.9 0.0 0.015 14.1 0.0 2.1 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.26 CCF34961.1 - 1.1e-06 28.4 0.0 2e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain TFIIA PF03153.8 CCF34961.1 - 1.5 8.6 5.5 2.6 7.8 3.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1290 PF06947.7 CCF34963.1 - 0.003 17.4 0.0 0.0032 17.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1290) Trypsin_2 PF13365.1 CCF34964.1 - 8.1e-06 25.8 0.0 2.2e-05 24.4 0.0 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S64 PF08192.6 CCF34964.1 - 0.0064 14.8 0.0 0.013 13.8 0.0 1.4 1 1 0 1 1 1 1 Peptidase family S64 SNF2_N PF00176.18 CCF34966.1 - 8.9e-75 251.2 0.6 1.6e-74 250.4 0.4 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CCF34966.1 - 3.4e-14 52.4 0.0 1.1e-13 50.8 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF34966.1 - 8e-08 32.3 0.0 1.6e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.3 CCF34966.1 - 9e-05 21.4 0.1 0.26 10.0 0.0 2.6 2 1 0 2 2 2 2 Class II histone deacetylase complex subunits 2 and 3 HSA PF07529.8 CCF34966.1 - 0.00014 21.6 6.8 0.00014 21.6 4.7 2.4 2 0 0 2 2 2 1 HSA DEAD PF00270.24 CCF34966.1 - 0.00026 20.5 0.0 0.0005 19.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase NDUF_B8 PF05821.6 CCF34967.1 - 1.7e-06 27.7 0.0 2.4e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) ADH_N PF08240.7 CCF34968.1 - 1.8e-05 24.4 0.1 0.00014 21.5 0.0 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain MFS_1 PF07690.11 CCF34969.1 - 1.7e-37 128.9 64.5 4e-37 127.7 41.9 3.1 2 1 0 2 2 2 1 Major Facilitator Superfamily InaF-motif PF15018.1 CCF34969.1 - 0.024 14.0 0.8 0.024 14.0 0.5 2.3 2 0 0 2 2 2 0 TRP-interacting helix p450 PF00067.17 CCF34970.1 - 8.7e-53 179.4 0.0 1.2e-52 179.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 NAD_binding_8 PF13450.1 CCF34971.1 - 5.1e-14 52.0 0.5 1e-13 51.0 0.0 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 CCF34971.1 - 3.7e-09 36.1 0.0 7.8e-09 35.1 0.0 1.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.2 CCF34971.1 - 3e-07 29.8 0.3 4.5e-06 26.0 0.2 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CCF34971.1 - 1.2e-06 27.6 0.4 2.1e-06 26.8 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF34971.1 - 7.1e-06 25.1 0.4 0.00017 20.6 0.7 2.4 2 1 1 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 CCF34971.1 - 3.9e-05 23.8 0.0 8.7e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF34971.1 - 4.3e-05 22.1 0.1 7.2e-05 21.4 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.9 CCF34971.1 - 0.00033 20.6 0.0 0.00077 19.3 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF34971.1 - 0.0012 19.1 0.7 0.0023 18.2 0.1 1.8 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF34971.1 - 0.0015 17.6 0.0 0.0033 16.5 0.0 1.5 1 0 0 1 1 1 1 Thi4 family ApbA PF02558.11 CCF34971.1 - 0.0053 16.2 0.0 0.009 15.4 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.14 CCF34971.1 - 0.0056 15.7 0.1 0.011 14.8 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.7 CCF34971.1 - 0.07 12.0 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein TrkA_N PF02254.13 CCF34971.1 - 0.078 12.9 0.2 0.21 11.5 0.0 1.8 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_7 PF13241.1 CCF34971.1 - 0.13 12.5 0.0 0.3 11.3 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding SET PF00856.23 CCF34973.1 - 8e-11 42.5 0.0 3e-08 34.1 0.0 2.3 2 0 0 2 2 2 2 SET domain TGT PF01702.13 CCF34973.1 - 0.092 12.0 0.3 0.16 11.1 0.0 1.5 2 0 0 2 2 2 0 Queuine tRNA-ribosyltransferase C2 PF00168.25 CCF34974.1 - 8.6e-11 41.5 0.0 1.7e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 C2 domain DUF629 PF04780.7 CCF34975.1 - 0.013 14.0 0.0 0.022 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF629) zf-H2C2_5 PF13909.1 CCF34975.1 - 0.027 14.6 0.2 0.051 13.8 0.1 1.4 1 0 0 1 1 1 0 C2H2-type zinc-finger domain DUF1840 PF08895.6 CCF34975.1 - 0.059 13.3 3.5 0.1 12.6 1.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) MRP-S31 PF15433.1 CCF34975.1 - 0.23 10.8 2.1 0.26 10.6 1.5 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 SseC PF04888.7 CCF34975.1 - 0.26 10.5 7.1 0.31 10.3 4.9 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family NTPase_I-T PF01931.13 CCF34976.1 - 2.8e-49 167.0 0.0 3.2e-49 166.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF84 Evr1_Alr PF04777.8 CCF34977.1 - 3.9e-26 90.7 0.1 5.6e-26 90.2 0.0 1.3 1 0 0 1 1 1 1 Erv1 / Alr family Proteasome PF00227.21 CCF34978.1 - 4e-48 163.2 0.3 4.8e-48 162.9 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Glyco_hydro_18 PF00704.23 CCF34983.1 - 5.9e-10 39.1 0.0 1.4e-09 37.8 0.0 1.6 1 1 1 2 2 2 1 Glycosyl hydrolases family 18 Ceramidase PF05875.7 CCF34984.1 - 2.1e-06 27.0 0.6 2.4e-06 26.8 0.4 1.0 1 0 0 1 1 1 1 Ceramidase Prefoldin_2 PF01920.15 CCF34985.1 - 2e-18 66.0 3.3 2.3e-18 65.8 2.1 1.2 1 1 0 1 1 1 1 Prefoldin subunit TMF_TATA_bd PF12325.3 CCF34985.1 - 0.0011 18.6 4.2 0.0014 18.3 0.2 2.0 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.3 CCF34985.1 - 0.037 13.8 3.7 0.037 13.8 2.6 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Cellsynth_D PF03500.8 CCF34985.1 - 0.054 13.1 0.0 0.066 12.8 0.0 1.1 1 0 0 1 1 1 0 Cellulose synthase subunit D TBPIP PF07106.8 CCF34985.1 - 0.09 12.3 3.9 0.19 11.2 0.5 2.0 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF3837 PF12939.2 CCF34985.1 - 0.091 12.7 0.9 0.16 11.9 0.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3837) FliJ PF02050.11 CCF34985.1 - 0.19 11.7 10.2 1.7 8.6 0.6 2.1 2 0 0 2 2 2 0 Flagellar FliJ protein DUF4349 PF14257.1 CCF34985.1 - 0.39 9.9 3.2 2.8 7.1 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) USP8_interact PF08941.5 CCF34985.1 - 0.49 9.6 3.1 0.34 10.2 0.6 1.7 1 1 0 2 2 2 0 USP8 interacting DUF641 PF04859.7 CCF34985.1 - 0.51 10.1 4.5 0.73 9.5 0.1 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Mod_r PF07200.8 CCF34985.1 - 0.59 10.0 6.2 3.2 7.6 0.7 2.1 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF745 PF05335.8 CCF34985.1 - 0.73 9.3 5.0 4.2 6.8 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Sec2p PF06428.6 CCF34985.1 - 0.86 9.4 5.0 0.66 9.8 0.6 2.1 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p DUF4200 PF13863.1 CCF34985.1 - 0.93 9.4 8.3 5.6 6.9 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Cep57_MT_bd PF06657.8 CCF34985.1 - 0.94 9.4 5.7 1.4 8.9 0.3 2.6 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Striatin PF08232.7 CCF34985.1 - 0.97 9.7 7.0 0.72 10.1 1.5 2.0 2 0 0 2 2 2 0 Striatin family THOC7 PF05615.8 CCF34985.1 - 1.3 9.3 7.2 9.4 6.5 1.3 2.1 2 0 0 2 2 2 0 Tho complex subunit 7 CENP-Q PF13094.1 CCF34985.1 - 1.5 8.8 7.3 0.43 10.5 1.4 2.0 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit PspA_IM30 PF04012.7 CCF34985.1 - 2.5 7.3 11.2 3.2 7.0 1.6 2.1 2 0 0 2 2 2 0 PspA/IM30 family ADIP PF11559.3 CCF34985.1 - 3 7.7 9.0 3.5 7.5 1.4 2.0 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding FliD_C PF07195.7 CCF34985.1 - 3.6 6.8 5.7 2 7.6 0.3 2.0 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Atg14 PF10186.4 CCF34985.1 - 6.8 5.5 8.4 56 2.5 5.8 1.9 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 FlxA PF14282.1 CCF34985.1 - 7.5 6.5 10.8 3.2 7.7 1.0 2.1 2 0 0 2 2 2 0 FlxA-like protein Prefoldin PF02996.12 CCF34985.1 - 9.4 5.9 9.8 4.9 6.8 0.8 2.2 2 0 0 2 2 2 0 Prefoldin subunit DUF2681 PF10883.3 CCF34985.1 - 9.5 6.5 8.7 8 6.7 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Mito_carr PF00153.22 CCF34987.1 - 1.2e-34 117.8 0.9 2.9e-19 68.5 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein HMG-CoA_red PF00368.13 CCF34989.1 - 6.9e-95 317.8 0.0 8.2e-95 317.5 0.0 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase TMEM154 PF15102.1 CCF34990.1 - 0.012 15.3 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family SMP_2 PF10144.4 CCF34990.1 - 0.027 13.5 0.1 0.035 13.2 0.0 1.1 1 0 0 1 1 1 0 Bacterial virulence factor haemolysin DUF3377 PF11857.3 CCF34990.1 - 0.052 13.1 0.0 0.072 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DUF2681 PF10883.3 CCF34990.1 - 0.11 12.6 0.3 0.16 12.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Peptidase_C65 PF10275.4 CCF34991.1 - 2.5e-52 177.6 0.0 2.8e-52 177.4 0.0 1.0 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.14 CCF34991.1 - 0.045 14.3 0.0 0.25 11.9 0.0 2.1 1 1 0 1 1 1 0 OTU-like cysteine protease AMP-binding PF00501.23 CCF34993.1 - 5.1e-103 344.6 0.1 8e-81 271.5 0.0 3.4 2 1 1 3 3 3 3 AMP-binding enzyme Condensation PF00668.15 CCF34993.1 - 2.4e-56 190.8 0.0 2.9e-36 124.8 0.0 3.5 2 1 0 2 2 2 2 Condensation domain PP-binding PF00550.20 CCF34993.1 - 2.1e-18 66.3 0.0 3.6e-08 33.5 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.1 CCF34993.1 - 9.3e-08 32.9 1.3 0.011 16.6 0.0 3.7 4 0 0 4 4 4 2 AMP-binding enzyme C-terminal domain Sugar_tr PF00083.19 CCF34994.1 - 1.1e-119 400.0 25.6 1.3e-119 399.8 17.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF34994.1 - 2.1e-21 76.0 46.3 8e-14 51.1 15.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Acetyltransf_1 PF00583.19 CCF34995.1 - 5.6e-11 42.3 0.1 1e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF34995.1 - 9.6e-07 28.8 0.0 1.9e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 CCF34995.1 - 3.6e-05 23.5 0.0 6.7e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_10 PF13673.1 CCF34995.1 - 6.7e-05 22.9 0.0 0.00011 22.3 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 CCF34995.1 - 0.0014 18.4 0.0 0.032 14.0 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF34995.1 - 0.013 15.2 0.0 0.026 14.2 0.0 1.5 1 1 0 1 1 1 0 FR47-like protein DUF2502 PF10697.4 CCF34996.1 - 0.069 13.2 5.0 0.18 11.9 3.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2502) SIP1 PF04938.7 CCF34996.1 - 0.1 11.9 0.2 5 6.4 0.0 2.7 3 0 0 3 3 3 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) CPSase_L_D3 PF02787.14 CCF34996.1 - 0.13 11.9 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain RNR_inhib PF08591.5 CCF34997.1 - 4e-24 85.3 0.6 7.5e-24 84.5 0.1 1.7 2 0 0 2 2 2 1 Ribonucleotide reductase inhibitor Ald_Xan_dh_C2 PF02738.13 CCF34999.1 - 9.7e-88 294.8 0.0 1.1e-87 294.6 0.0 1.0 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase DUF218 PF02698.12 CCF34999.1 - 0.0037 16.7 0.1 0.0074 15.7 0.0 1.4 1 0 0 1 1 1 1 DUF218 domain PAS PF00989.19 CCF35000.1 - 0.061 13.1 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 PAS fold Transp_cyt_pur PF02133.10 CCF35001.1 - 2.5e-35 121.8 34.7 3.6e-35 121.3 24.1 1.3 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin CoA_transf_3 PF02515.12 CCF35003.1 - 2.8e-44 150.6 0.0 1e-42 145.5 0.0 2.1 2 0 0 2 2 2 2 CoA-transferase family III FAD_binding_3 PF01494.14 CCF35004.1 - 1.7e-11 43.7 0.0 9.3e-11 41.3 0.0 2.1 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 CCF35004.1 - 0.002 18.0 0.0 0.0032 17.3 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF35004.1 - 0.0054 16.7 0.0 0.014 15.4 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 CCF35004.1 - 0.063 11.7 0.1 0.098 11.1 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein AlaDh_PNT_C PF01262.16 CCF35004.1 - 0.069 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF2408 PF10303.4 CCF35005.1 - 0.024 14.7 3.8 0.088 12.9 2.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) Transcrip_act PF04949.8 CCF35005.1 - 0.26 10.8 7.3 1.5 8.4 0.7 2.2 1 1 1 2 2 2 0 Transcriptional activator Ank_2 PF12796.2 CCF35006.1 - 3.9e-54 180.9 2.6 9.2e-14 51.5 0.1 4.2 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 CCF35006.1 - 5e-36 120.7 0.2 1.6e-05 24.4 0.0 8.4 8 0 0 8 8 8 8 Ankyrin repeat Ank_4 PF13637.1 CCF35006.1 - 1.8e-34 117.4 6.4 1.3e-09 38.2 0.0 6.6 1 1 6 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF35006.1 - 4e-34 113.2 0.1 2.4e-05 24.1 0.0 8.7 8 0 0 8 8 8 7 Ankyrin repeat Ank_5 PF13857.1 CCF35006.1 - 3.7e-31 106.4 7.2 5.1e-08 32.9 0.1 6.7 2 2 4 6 6 6 6 Ankyrin repeats (many copies) NACHT PF05729.7 CCF35006.1 - 0.00019 21.1 0.1 0.00045 19.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain HET PF06985.6 CCF35007.1 - 2e-25 89.5 0.3 1.8e-24 86.4 0.0 2.3 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) F-box-like PF12937.2 CCF35009.1 - 2.3e-07 30.4 0.3 5.7e-07 29.1 0.2 1.7 1 0 0 1 1 1 1 F-box-like 2-Hacid_dh_C PF02826.14 CCF35010.1 - 1.9e-40 137.8 0.0 3.2e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 CCF35010.1 - 8.5e-11 41.4 0.0 1.1e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GFO_IDH_MocA PF01408.17 CCF35010.1 - 0.00012 22.5 0.0 0.00021 21.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold TrkA_N PF02254.13 CCF35010.1 - 0.00055 19.9 0.1 0.0024 17.8 0.0 2.0 2 1 0 2 2 2 1 TrkA-N domain Gp_dh_N PF00044.19 CCF35010.1 - 0.0048 16.8 0.0 0.0096 15.8 0.0 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain F420_oxidored PF03807.12 CCF35010.1 - 0.0049 17.2 0.1 0.0099 16.2 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.15 CCF35010.1 - 0.016 15.1 0.0 0.033 14.1 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_2 PF03446.10 CCF35010.1 - 0.017 14.9 0.1 0.04 13.7 0.0 1.6 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_C PF03720.10 CCF35010.1 - 0.044 13.9 0.0 7.9 6.6 0.0 2.4 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Saccharop_dh PF03435.13 CCF35010.1 - 0.078 11.9 0.0 0.12 11.2 0.0 1.4 1 1 0 1 1 1 0 Saccharopine dehydrogenase AAA PF00004.24 CCF35012.1 - 1e-49 168.1 0.0 1.4e-43 148.2 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CCF35012.1 - 3.5e-05 24.6 0.0 0.00044 21.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 CCF35012.1 - 5.1e-05 22.7 0.1 0.00041 19.7 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CCF35012.1 - 0.00022 21.3 0.1 0.0037 17.4 0.0 2.8 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.7 CCF35012.1 - 0.00026 20.1 0.0 0.00062 18.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Parvo_NS1 PF01057.12 CCF35012.1 - 0.00065 18.6 0.0 0.0011 17.8 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 IstB_IS21 PF01695.12 CCF35012.1 - 0.00096 18.6 0.0 0.0023 17.3 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.1 CCF35012.1 - 0.0014 18.6 1.8 0.022 14.7 0.0 3.1 2 1 1 3 3 2 1 AAA ATPase domain AAA_2 PF07724.9 CCF35012.1 - 0.0033 17.3 0.0 0.0074 16.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_19 PF13245.1 CCF35012.1 - 0.0045 16.7 0.0 0.017 14.8 0.0 2.0 1 0 0 1 1 1 1 Part of AAA domain TIP49 PF06068.8 CCF35012.1 - 0.01 14.6 0.0 0.016 13.9 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus RNA_helicase PF00910.17 CCF35012.1 - 0.01 16.0 0.0 0.033 14.3 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.9 CCF35012.1 - 0.016 14.9 0.0 0.065 12.9 0.0 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 CCF35012.1 - 0.019 14.1 0.9 0.046 12.8 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI KaiC PF06745.8 CCF35012.1 - 0.034 13.2 0.0 0.072 12.2 0.0 1.4 1 0 0 1 1 1 0 KaiC PhoH PF02562.11 CCF35012.1 - 0.039 13.1 0.0 0.077 12.2 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_14 PF13173.1 CCF35012.1 - 0.051 13.4 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 CCF35012.1 - 0.056 13.3 0.0 0.24 11.2 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 CCF35012.1 - 0.063 13.2 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CCF35012.1 - 0.069 13.4 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.8 CCF35012.1 - 0.15 10.9 0.0 0.27 10.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PPV_E1_C PF00519.12 CCF35012.1 - 0.31 9.5 0.0 0.49 8.9 0.0 1.1 1 0 0 1 1 1 0 Papillomavirus helicase AAA_24 PF13479.1 CCF35012.1 - 0.38 10.3 1.9 0.29 10.6 0.1 1.7 2 0 0 2 2 2 0 AAA domain OPT PF03169.10 CCF35014.1 - 1.1e-168 562.5 45.3 1.3e-168 562.2 31.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein MBF1 PF08523.5 CCF35015.1 - 4.1e-26 90.7 2.3 8.5e-26 89.7 1.6 1.5 1 0 0 1 1 1 1 Multiprotein bridging factor 1 HTH_3 PF01381.17 CCF35015.1 - 7.8e-11 41.6 0.0 1.3e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.2 CCF35015.1 - 0.00029 20.8 0.0 0.00045 20.2 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.1 CCF35015.1 - 0.00052 20.1 0.0 0.00095 19.3 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain MRP-L27 PF09809.4 CCF35015.1 - 0.02 14.5 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L27 Mito_fiss_reg PF05308.6 CCF35017.1 - 2.4 7.4 5.9 2.8 7.2 4.1 1.2 1 1 0 1 1 1 0 Mitochondrial fission regulator Peptidase_S8 PF00082.17 CCF35018.1 - 2.9e-30 105.4 3.1 8.2e-29 100.6 0.4 2.1 2 0 0 2 2 2 2 Subtilase family Neur PF00064.13 CCF35019.1 - 0.00017 19.8 0.1 0.00024 19.3 0.1 1.2 1 0 0 1 1 1 1 Neuraminidase RICTOR_V PF14668.1 CCF35019.1 - 0.0017 18.2 0.4 0.004 17.0 0.3 1.6 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, domain 5 Caleosin PF05042.8 CCF35019.1 - 0.035 13.6 0.0 0.064 12.8 0.0 1.4 1 0 0 1 1 1 0 Caleosin related protein Transp_cyt_pur PF02133.10 CCF35020.1 - 1.3e-33 116.2 28.1 2.4e-32 112.0 19.4 2.0 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Glyco_hydro_47 PF01532.15 CCF35021.1 - 7.7e-168 558.8 0.0 9e-168 558.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Alpha-L-AF_C PF06964.7 CCF35022.1 - 4.8e-39 133.9 0.2 5.6e-39 133.7 0.1 1.0 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminus FlgD_ig PF13860.1 CCF35022.1 - 0.0053 16.4 0.5 0.0099 15.6 0.3 1.4 1 0 0 1 1 1 1 FlgD Ig-like domain IncA PF04156.9 CCF35023.1 - 0.0062 16.1 2.3 0.0062 16.1 1.6 7.2 4 2 3 8 8 8 2 IncA protein Tup_N PF08581.5 CCF35023.1 - 0.0083 16.3 9.6 0.17 12.1 0.0 5.6 4 0 0 4 4 4 1 Tup N-terminal DUF2730 PF10805.3 CCF35023.1 - 0.061 13.0 18.8 3 7.6 0.4 5.9 2 1 2 4 4 4 0 Protein of unknown function (DUF2730) CCD PF07860.6 CCF35023.1 - 0.24 10.8 0.1 1.7 8.1 0.0 2.6 2 0 0 2 2 2 0 WisP family C-Terminal Region RTA1 PF04479.8 CCF35025.1 - 4.2e-18 65.6 6.2 1.1e-17 64.2 4.3 1.6 1 1 0 1 1 1 1 RTA1 like protein DUF4501 PF14946.1 CCF35025.1 - 0.57 9.6 2.9 0.23 10.8 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4501) Inp1 PF12634.2 CCF35026.1 - 4e-28 97.9 0.0 1.4e-27 96.1 0.0 1.9 2 0 0 2 2 2 1 Inheritance of peroxisomes protein 1 VirionAssem_T7 PF11653.3 CCF35026.1 - 1.1 10.0 5.0 0.34 11.6 0.3 2.5 2 0 0 2 2 2 0 Bacteriophage T7 virion assembly protein COesterase PF00135.23 CCF35028.1 - 4.3e-71 240.2 0.0 5.9e-71 239.7 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF35028.1 - 3e-09 36.7 0.4 2e-08 34.0 0.3 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF35028.1 - 0.00066 19.4 0.1 0.0012 18.5 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF35028.1 - 0.0012 18.0 0.9 0.002 17.3 0.6 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.2 CCF35028.1 - 0.0037 16.1 0.0 0.0083 15.0 0.0 1.5 1 0 0 1 1 1 1 Chlorophyllase enzyme DUF2424 PF10340.4 CCF35028.1 - 0.042 12.4 0.0 1.8 7.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2424) AXE1 PF05448.7 CCF35028.1 - 0.089 11.2 0.0 0.5 8.8 0.0 1.8 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) DUF3605 PF12239.3 CCF35029.1 - 1.2e-40 139.0 0.3 1.5e-40 138.6 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) His_Phos_2 PF00328.17 CCF35030.1 - 1.2e-19 70.8 0.0 2.5e-17 63.2 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) ABM PF03992.11 CCF35030.1 - 0.095 12.7 0.0 0.26 11.3 0.0 1.8 1 0 0 1 1 1 0 Antibiotic biosynthesis monooxygenase Hexapep PF00132.19 CCF35031.1 - 2.9e-14 51.8 6.6 8.8e-10 37.6 2.1 3.3 2 1 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 CCF35031.1 - 2e-13 49.6 7.5 2.2e-10 39.9 1.7 3.0 2 1 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Mac PF12464.3 CCF35031.1 - 2.8e-09 36.8 0.1 4.6e-09 36.1 0.1 1.3 1 0 0 1 1 1 1 Maltose acetyltransferase Vac14_Fig4_bd PF11916.3 CCF35032.1 - 0.031 13.4 0.3 0.033 13.3 0.2 1.0 1 0 0 1 1 1 0 Vacuolar protein 14 C-terminal Fig4p binding adh_short PF00106.20 CCF35034.1 - 1.7e-13 50.8 0.0 2.9e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF35034.1 - 3.6e-07 30.0 0.0 5.1e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 KR domain Pkinase PF00069.20 CCF35035.1 - 1e-15 57.6 0.0 7.4e-15 54.7 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF35035.1 - 9.7e-09 34.6 0.0 5.6e-08 32.1 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 CCF35035.1 - 3.9e-05 22.8 0.0 6.1e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 CCF35035.1 - 0.0082 15.1 0.1 0.45 9.4 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 CCF35035.1 - 0.095 12.4 0.3 1.2 8.7 0.3 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.17 CCF35035.1 - 0.15 11.3 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 RIO1 family MFS_1 PF07690.11 CCF35036.1 - 1.4e-43 149.0 26.4 1.4e-43 149.0 18.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF35036.1 - 1.2e-13 50.4 10.8 1.2e-13 50.4 7.5 2.3 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.8 CCF35036.1 - 2.3e-11 42.6 3.1 4.1e-11 41.8 2.1 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.1 CCF35036.1 - 1.1e-05 23.9 2.4 1.1e-05 23.9 1.7 3.4 2 2 1 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.2 CCF35036.1 - 0.0025 17.5 1.7 0.046 13.5 0.0 3.2 3 0 0 3 3 3 1 MFS_1 like family DUF3753 PF12575.3 CCF35036.1 - 8.5 6.2 7.3 1.2 8.9 0.7 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3753) MFS_1 PF07690.11 CCF35037.1 - 3e-32 111.7 14.4 3e-32 111.7 10.0 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF35037.1 - 0.012 15.3 2.5 0.013 15.2 0.2 2.2 2 0 0 2 2 2 0 MFS_1 like family U3_assoc_6 PF08640.6 CCF35037.1 - 0.18 11.5 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 U3 small nucleolar RNA-associated protein 6 Caleosin PF05042.8 CCF35038.1 - 1.9e-50 170.8 0.0 2.4e-50 170.5 0.0 1.1 1 0 0 1 1 1 1 Caleosin related protein EF-hand_6 PF13405.1 CCF35038.1 - 5.4e-05 22.7 0.4 3.6 7.7 0.0 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.27 CCF35038.1 - 0.012 14.9 0.2 3.5 7.1 0.0 3.6 3 0 0 3 3 3 0 EF hand Xpo1 PF08389.7 CCF35040.1 - 3.6e-29 101.5 1.8 4.7e-28 97.9 0.2 3.6 3 1 1 4 4 4 1 Exportin 1-like protein IBN_N PF03810.14 CCF35040.1 - 1.6e-06 27.9 0.0 6.5e-06 25.9 0.0 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain HEAT_2 PF13646.1 CCF35040.1 - 0.00023 21.3 2.7 0.27 11.5 0.0 4.8 5 1 0 5 5 5 1 HEAT repeats Adaptin_N PF01602.15 CCF35040.1 - 0.0047 15.3 0.9 0.21 9.8 0.1 2.6 3 0 0 3 3 3 2 Adaptin N terminal region COG4 PF08318.7 CCF35041.1 - 1.1e-100 336.6 0.0 1.9e-100 335.8 0.0 1.4 1 0 0 1 1 1 1 COG4 transport protein HSCB_C PF07743.8 CCF35041.1 - 0.059 13.8 3.3 0.63 10.5 0.3 3.1 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain Autophagy_Cterm PF10381.4 CCF35041.1 - 1.7 7.7 4.0 6.8 5.8 0.4 2.3 2 0 0 2 2 2 0 Autophagocytosis associated protein C-terminal E1-E2_ATPase PF00122.15 CCF35042.1 - 3.8e-72 242.0 0.1 8.1e-72 240.9 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CCF35042.1 - 9.5e-43 145.8 0.7 1.9e-42 144.8 0.5 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CCF35042.1 - 2.8e-31 109.6 0.0 3.5e-30 106.0 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 CCF35042.1 - 8.9e-21 73.1 0.0 1.9e-20 72.1 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 CCF35042.1 - 3.6e-16 59.9 0.0 8.8e-16 58.6 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF35042.1 - 6e-13 48.5 0.0 1.1e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 CCF35042.1 - 0.00022 20.8 0.3 0.00047 19.8 0.2 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Transport_MerF PF11431.3 CCF35042.1 - 0.07 12.7 0.2 0.2 11.3 0.1 1.7 1 0 0 1 1 1 0 Membrane transport protein MerF C2 PF00168.25 CCF35043.1 - 1.9e-13 50.0 0.0 4e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 C2 domain Peptidase_M24 PF00557.19 CCF35044.1 - 6.2e-41 140.2 0.1 7.9e-41 139.9 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 YL1 PF05764.8 CCF35044.1 - 0.0097 15.5 1.6 0.013 15.1 1.1 1.2 1 0 0 1 1 1 1 YL1 nuclear protein TSGP1 PF07771.6 CCF35044.1 - 1.4 8.8 7.2 3 7.7 5.0 1.5 1 0 0 1 1 1 0 Tick salivary peptide group 1 MIP PF00230.15 CCF35045.1 - 3.6e-53 180.3 6.9 4.5e-53 180.0 4.8 1.1 1 0 0 1 1 1 1 Major intrinsic protein DUF3438 PF11920.3 CCF35048.1 - 0.048 12.5 0.0 0.057 12.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) CathepsinC_exc PF08773.6 CCF35049.1 - 0.072 13.2 0.1 0.091 12.9 0.1 1.2 1 0 0 1 1 1 0 Cathepsin C exclusion domain DUF1749 PF08538.5 CCF35050.1 - 4.8e-78 262.1 0.0 5.6e-78 261.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.2 CCF35050.1 - 1.1e-13 51.6 0.0 1.4e-13 51.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF35050.1 - 3.6e-09 36.5 0.0 1.6e-08 34.3 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF35050.1 - 0.00038 20.0 0.0 0.0011 18.5 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Gly-zipper_Omp PF13488.1 CCF35050.1 - 0.041 13.5 2.3 0.096 12.3 1.6 1.6 1 0 0 1 1 1 0 Glycine zipper Gly-zipper_OmpA PF13436.1 CCF35050.1 - 0.085 12.5 0.8 0.19 11.3 0.5 1.6 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain MFS_1 PF07690.11 CCF35052.1 - 1.2e-25 89.9 23.1 1.5e-25 89.6 16.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2157 PF09925.4 CCF35052.1 - 0.85 9.2 7.7 0.089 12.4 1.2 2.4 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) Helicase_C PF00271.26 CCF35054.1 - 5.8e-23 80.5 0.2 1.1e-18 66.9 0.0 3.3 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.24 CCF35054.1 - 3.5e-21 75.4 0.1 1.5e-20 73.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase RQC PF09382.5 CCF35054.1 - 6.2e-11 41.9 0.0 1.5e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 RQC domain SNF2_N PF00176.18 CCF35054.1 - 0.00016 20.5 0.0 0.00025 19.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HRDC PF00570.18 CCF35054.1 - 0.00078 19.1 0.0 0.0023 17.6 0.0 1.8 1 0 0 1 1 1 1 HRDC domain SecA_DEAD PF07517.9 CCF35054.1 - 0.028 13.7 0.0 0.064 12.5 0.0 1.6 1 0 0 1 1 1 0 SecA DEAD-like domain KAR9 PF08580.5 CCF35055.1 - 1.2e-128 430.2 0.0 1.2e-128 430.2 0.0 2.0 2 0 0 2 2 2 1 Yeast cortical protein KAR9 Syntaxin-6_N PF09177.6 CCF35055.1 - 0.01 16.2 7.8 0.11 12.8 0.4 4.3 4 1 0 4 4 4 0 Syntaxin 6, N-terminal HET PF06985.6 CCF35056.1 - 1.8e-25 89.7 0.3 9.7e-25 87.3 0.2 2.2 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Voldacs PF03517.8 CCF35056.1 - 0.12 12.1 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling Peptidase_S8 PF00082.17 CCF35057.1 - 6.5e-31 107.5 0.0 1.2e-30 106.6 0.0 1.4 1 1 0 1 1 1 1 Subtilase family PA PF02225.17 CCF35057.1 - 9e-08 31.7 0.0 6.8e-07 28.9 0.0 2.3 2 0 0 2 2 2 1 PA domain DUF1034 PF06280.7 CCF35057.1 - 9.5e-07 29.2 0.0 1.3e-05 25.5 0.0 2.4 2 0 0 2 2 2 1 Fn3-like domain (DUF1034) PNTB PF02233.11 CCF35059.1 - 1.6e-167 557.9 28.0 1.6e-167 557.9 19.4 1.7 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.16 CCF35059.1 - 3.1e-54 183.0 0.4 5.7e-54 182.1 0.3 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.10 CCF35059.1 - 7.5e-50 168.4 0.0 1.8e-49 167.2 0.0 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain DUF3814 PF12769.2 CCF35059.1 - 1.5e-31 108.3 3.4 1.5e-31 108.3 2.3 5.2 5 1 1 6 6 6 1 Domain of unknown function (DUF3814) 2-Hacid_dh_C PF02826.14 CCF35059.1 - 0.0071 15.5 0.1 0.94 8.6 0.0 2.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.9 CCF35059.1 - 0.017 14.9 0.9 0.055 13.3 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Fumerase PF05681.9 CCF35059.1 - 0.019 14.0 0.1 0.037 13.0 0.1 1.4 1 0 0 1 1 1 0 Fumarate hydratase (Fumerase) Methyltransf_18 PF12847.2 CCF35059.1 - 0.048 14.2 0.0 0.12 12.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain NAD_binding_8 PF13450.1 CCF35059.1 - 0.056 13.4 2.2 0.48 10.4 1.3 2.9 2 1 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Methyltransf_31 PF13847.1 CCF35059.1 - 0.057 13.0 0.0 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain NAD_binding_7 PF13241.1 CCF35060.1 - 1.8e-32 111.6 0.0 3e-32 110.9 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.1 CCF35060.1 - 9.6e-24 82.4 0.0 1.4e-23 81.9 0.0 1.3 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.1 CCF35060.1 - 7e-16 56.9 0.3 1.2e-15 56.1 0.2 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Pyr_redox_3 PF13738.1 CCF35060.1 - 0.012 15.7 0.1 0.065 13.2 0.0 1.9 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.16 CCF35060.1 - 0.04 13.7 0.9 0.093 12.5 0.0 1.9 2 0 0 2 2 2 0 ThiF family TrkA_N PF02254.13 CCF35060.1 - 0.065 13.2 0.1 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain FYVE PF01363.16 CCF35061.1 - 7.9e-24 83.3 20.1 1e-16 60.5 2.6 3.0 3 0 0 3 3 3 2 FYVE zinc finger Rbsn PF11464.3 CCF35061.1 - 0.00018 21.0 1.2 0.0005 19.5 0.8 1.8 1 0 0 1 1 1 1 Rabenosyn Rab binding domain zf-Di19 PF05605.7 CCF35061.1 - 0.00032 20.7 6.1 0.013 15.6 0.1 2.8 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-AN1 PF01428.11 CCF35061.1 - 0.0011 18.8 2.4 0.0011 18.8 1.7 3.4 3 1 0 3 3 3 2 AN1-like Zinc finger HypA PF01155.14 CCF35061.1 - 0.28 10.8 7.0 1.8 8.3 0.1 3.3 3 0 0 3 3 3 0 Hydrogenase expression/synthesis hypA family zf-NADH-PPase PF09297.6 CCF35061.1 - 0.76 9.3 14.3 0.14 11.6 0.1 3.8 4 0 0 4 4 4 0 NADH pyrophosphatase zinc ribbon domain IBR PF01485.16 CCF35061.1 - 7 6.6 14.8 0.29 11.0 0.7 3.3 3 1 0 3 3 3 0 IBR domain PPR_3 PF13812.1 CCF35064.1 - 1e-15 56.5 2.1 0.0019 18.3 0.0 6.5 7 0 0 7 7 7 3 Pentatricopeptide repeat domain PPR_2 PF13041.1 CCF35064.1 - 1.8e-15 56.6 1.4 0.00084 19.2 0.0 5.3 4 1 1 5 5 5 4 PPR repeat family PPR PF01535.15 CCF35064.1 - 6.3e-06 25.8 12.8 0.00037 20.2 0.0 5.5 6 1 0 6 6 6 2 PPR repeat PPR_1 PF12854.2 CCF35064.1 - 0.0047 16.3 4.6 2.3 7.7 0.0 4.3 4 1 0 4 4 4 2 PPR repeat DUF2095 PF09868.4 CCF35064.1 - 0.037 13.8 0.0 0.088 12.5 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) COX7C PF02935.11 CCF35065.1 - 2.9e-15 55.8 1.7 4.3e-15 55.2 1.2 1.4 1 1 0 1 1 1 1 Cytochrome c oxidase subunit VIIc rRNA_proc-arch PF13234.1 CCF35066.1 - 5.1e-89 297.9 0.0 9.4e-89 297.1 0.0 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.7 CCF35066.1 - 5.4e-58 195.1 1.6 5.4e-58 195.1 1.1 1.8 2 0 0 2 2 2 1 DSHCT (NUC185) domain DEAD PF00270.24 CCF35066.1 - 2.8e-22 79.0 0.0 1.4e-21 76.7 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF35066.1 - 1.7e-08 34.1 0.0 3.9e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF35066.1 - 0.0055 16.5 0.0 0.068 13.0 0.0 2.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit T2SE PF00437.15 CCF35066.1 - 0.026 13.4 0.0 0.054 12.3 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF4303 PF14136.1 CCF35066.1 - 0.096 12.3 2.0 0.41 10.2 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4303) DUF2407_C PF13373.1 CCF35067.1 - 8.2e-11 41.9 0.3 9e-11 41.8 0.2 1.0 1 0 0 1 1 1 1 DUF2407 C-terminal domain Mito_fiss_reg PF05308.6 CCF35068.1 - 0.36 10.1 5.8 0.33 10.2 4.0 1.0 1 0 0 1 1 1 0 Mitochondrial fission regulator Pheromone PF08015.6 CCF35068.1 - 1 10.2 3.8 1.2 10.0 2.7 1.1 1 0 0 1 1 1 0 Fungal mating-type pheromone Glyco_hydro_76 PF03663.9 CCF35069.1 - 1.6e-156 521.3 13.7 2.1e-156 520.9 9.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.8 CCF35069.1 - 0.031 13.3 12.2 0.41 9.6 0.7 3.4 2 2 1 3 3 3 0 Glycosyl Hydrolase Family 88 2OG-FeII_Oxy_3 PF13640.1 CCF35070.1 - 7.5e-09 36.0 0.1 1.5e-08 35.0 0.0 1.5 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 CCF35070.1 - 0.012 15.2 0.0 0.027 14.1 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DUF3176 PF11374.3 CCF35071.1 - 4.9e-08 32.8 0.0 5.9e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) CBM_20 PF00686.14 CCF35072.1 - 1.6e-32 110.9 0.7 3e-32 110.1 0.5 1.5 1 0 0 1 1 1 1 Starch binding domain Chitin_bind_3 PF03067.10 CCF35072.1 - 7.5e-07 29.5 2.8 4.3e-05 23.8 0.0 2.8 3 0 0 3 3 3 2 Chitin binding domain CBM_25 PF03423.8 CCF35072.1 - 0.031 14.3 0.2 0.32 11.1 0.0 2.2 2 0 0 2 2 2 0 Carbohydrate binding domain (family 25) Pectate_lyase_3 PF12708.2 CCF35073.1 - 9.2e-71 238.5 11.1 7.3e-59 199.6 6.6 2.6 2 0 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.3 CCF35073.1 - 9.1e-06 25.0 1.3 0.037 13.5 0.1 2.7 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase Cecropin PF00272.14 CCF35074.1 - 0.035 13.6 0.3 0.089 12.3 0.0 1.7 2 0 0 2 2 2 0 Cecropin family GFA PF04828.9 CCF35077.1 - 7.4e-23 80.3 0.0 1e-22 79.8 0.0 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Nudix_N_2 PF14803.1 CCF35077.1 - 0.13 11.9 0.1 0.13 11.9 0.0 2.6 3 0 0 3 3 3 0 Nudix N-terminal zinc_ribbon_2 PF13240.1 CCF35077.1 - 0.15 11.5 1.1 0.26 10.8 0.0 2.0 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.2 CCF35077.1 - 0.19 11.5 2.6 0.33 10.7 0.6 2.2 2 1 1 3 3 3 0 Double zinc ribbon Rif1_N PF12231.3 CCF35079.1 - 3.1e-140 467.3 0.8 4.1e-140 466.9 0.5 1.2 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal Ribosomal_L22e PF01776.12 CCF35080.1 - 5e-25 87.6 0.2 6.5e-25 87.3 0.2 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family TelA PF05816.6 CCF35080.1 - 0.07 11.8 0.1 0.081 11.6 0.1 1.0 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) Herpes_gI PF01688.12 CCF35080.1 - 0.077 12.1 0.0 0.094 11.8 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein I A_deaminase PF00962.17 CCF35081.1 - 2.4e-41 141.7 0.0 3.1e-40 138.1 0.0 2.0 2 0 0 2 2 2 1 Adenosine/AMP deaminase Formyl_trans_C PF02911.13 CCF35081.1 - 0.034 14.2 0.0 0.069 13.2 0.0 1.5 1 0 0 1 1 1 0 Formyl transferase, C-terminal domain MFS_1 PF07690.11 CCF35082.1 - 1.1e-27 96.7 33.7 3.3e-26 91.8 13.8 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily BSP PF04450.7 CCF35082.1 - 0.014 14.8 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Peptidase of plants and bacteria Hydantoinase_B PF02538.9 CCF35084.1 - 6.5e-201 668.1 0.5 6.1e-194 645.1 0.0 2.1 1 1 1 2 2 2 2 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.13 CCF35084.1 - 3.9e-71 239.5 0.2 7.4e-71 238.5 0.1 1.5 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Polysacc_deac_1 PF01522.16 CCF35086.1 - 1.3e-14 53.8 0.0 4.6e-14 52.0 0.0 1.8 2 0 0 2 2 2 1 Polysaccharide deacetylase p450 PF00067.17 CCF35087.1 - 1e-42 146.2 0.0 2.9e-42 144.7 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 Filament PF00038.16 CCF35088.1 - 0.28 10.6 49.4 0.77 9.1 0.9 3.3 2 1 0 2 2 2 0 Intermediate filament protein DUF724 PF05266.9 CCF35088.1 - 2.9 7.4 51.0 0.34 10.4 3.2 4.1 3 1 1 4 4 4 0 Protein of unknown function (DUF724) Peptidase_S41 PF03572.13 CCF35089.1 - 6.6e-07 28.8 0.0 1.5e-06 27.7 0.0 1.6 1 1 0 1 1 1 1 Peptidase family S41 DUF4613 PF15390.1 CCF35090.1 - 0.21 9.7 0.2 0.3 9.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) BRO1 PF03097.13 CCF35092.1 - 1.4e-130 435.4 0.4 1.4e-130 435.4 0.2 2.5 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 CCF35092.1 - 3.7e-95 318.3 18.3 8.6e-95 317.1 12.7 1.6 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Cu-oxidase PF00394.17 CCF35095.1 - 9.9e-16 58.0 0.1 1.9e-15 57.1 0.1 1.4 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 CCF35095.1 - 1.2e-09 37.7 0.1 1.5e-08 34.2 0.0 2.3 2 0 0 2 2 2 1 Multicopper oxidase Abhydrolase_6 PF12697.2 CCF35096.1 - 4.3e-24 85.6 0.1 5.1e-24 85.4 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF35096.1 - 2.8e-12 46.7 0.0 4.7e-12 45.9 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF35096.1 - 3.8e-07 29.9 0.0 2.8e-06 27.1 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.5 CCF35096.1 - 0.00073 19.3 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein FSH1 PF03959.8 CCF35096.1 - 0.0024 17.3 0.0 0.0092 15.4 0.0 1.9 2 1 1 3 3 3 1 Serine hydrolase (FSH1) Ndr PF03096.9 CCF35096.1 - 0.033 12.6 0.0 0.051 12.0 0.0 1.2 1 0 0 1 1 1 0 Ndr family Abhydrolase_8 PF06259.7 CCF35096.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase Cu-oxidase_3 PF07732.10 CCF35097.1 - 1.5e-32 111.8 0.6 2.8e-31 107.7 0.2 2.8 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 CCF35097.1 - 3.4e-19 68.7 12.5 1.6e-15 56.8 0.9 4.3 3 1 0 3 3 3 3 Multicopper oxidase Cu-oxidase PF00394.17 CCF35097.1 - 4.6e-19 68.8 0.0 2.5e-18 66.4 0.0 2.3 3 0 0 3 3 3 1 Multicopper oxidase NmrA PF05368.8 CCF35098.1 - 2.8e-54 183.8 0.2 3.5e-54 183.5 0.2 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF35098.1 - 7e-13 48.9 0.7 1e-12 48.4 0.5 1.2 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 CCF35098.1 - 0.00087 18.0 0.0 0.0013 17.5 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.19 CCF35098.1 - 0.0032 17.7 0.3 0.0061 16.8 0.2 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Pectate_lyase PF03211.8 CCF35099.1 - 7.5e-65 218.3 0.0 9.4e-65 218.0 0.0 1.1 1 0 0 1 1 1 1 Pectate lyase DUF2424 PF10340.4 CCF35101.1 - 3.1e-17 62.2 0.0 9.2e-09 34.4 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2424) Abhydrolase_3 PF07859.8 CCF35101.1 - 5.6e-15 55.4 0.0 1.1e-14 54.5 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF35101.1 - 0.024 14.4 0.0 0.028 14.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF35101.1 - 0.076 12.2 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family COesterase PF00135.23 CCF35101.1 - 0.096 11.3 0.0 0.14 10.8 0.0 1.1 1 0 0 1 1 1 0 Carboxylesterase family mRNA_cap_enzyme PF01331.14 CCF35102.1 - 1.5e-54 184.6 1.2 2.2e-54 184.1 0.9 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.10 CCF35102.1 - 9.4e-21 74.1 0.0 1.7e-20 73.2 0.0 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.16 CCF35102.1 - 5.2e-10 39.0 0.5 3.5e-08 33.0 0.4 2.3 1 1 0 1 1 1 1 ATP dependent DNA ligase domain Aldo_ket_red PF00248.16 CCF35103.1 - 6.6e-47 159.6 0.0 7.6e-47 159.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family IBR PF01485.16 CCF35104.1 - 7.5e-14 51.3 32.2 3.9e-08 33.0 2.1 3.7 3 0 0 3 3 3 2 IBR domain zf-C3HC4_2 PF13923.1 CCF35104.1 - 2.6e-05 24.1 4.2 2.6e-05 24.1 2.9 3.8 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF35104.1 - 0.00028 20.5 3.6 0.00028 20.5 2.5 3.7 4 0 0 4 4 4 1 zinc-RING finger domain zf-C3HC4 PF00097.20 CCF35104.1 - 0.0003 20.3 3.4 0.0003 20.3 2.4 3.4 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF35104.1 - 0.00043 19.9 4.9 0.00043 19.9 3.4 3.9 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF35104.1 - 0.0022 17.7 5.8 0.0022 17.7 4.0 3.6 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_4 PF15227.1 CCF35104.1 - 0.0036 17.1 2.9 0.0036 17.1 2.0 4.0 3 2 0 3 3 3 1 zinc finger of C3HC4-type, RING RRM_5 PF13893.1 CCF35104.1 - 0.0037 17.0 0.1 0.31 10.9 0.0 2.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_UBOX PF13445.1 CCF35104.1 - 0.0073 16.0 1.6 0.0073 16.0 1.1 2.5 2 0 0 2 2 2 1 RING-type zinc-finger RRM_1 PF00076.17 CCF35104.1 - 0.2 11.3 0.2 5.9 6.6 0.0 3.2 5 0 0 5 5 5 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) bZIP_1 PF00170.16 CCF35105.1 - 1.3e-08 34.6 8.5 2.3e-08 33.8 5.9 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 CCF35105.1 - 2.3e-06 27.3 11.7 2.3e-06 27.3 8.1 1.5 2 0 0 2 2 2 1 Basic region leucine zipper TPD52 PF04201.10 CCF35105.1 - 0.0044 16.7 0.8 0.0063 16.2 0.5 1.3 1 0 0 1 1 1 1 Tumour protein D52 family DUF4140 PF13600.1 CCF35105.1 - 0.073 13.5 3.1 0.1 13.0 2.2 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DUF641 PF04859.7 CCF35105.1 - 0.086 12.6 2.4 0.15 11.8 1.7 1.5 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) bZIP_Maf PF03131.12 CCF35105.1 - 1.1 9.5 11.6 0.079 13.2 4.6 1.6 2 0 0 2 2 2 0 bZIP Maf transcription factor Myb_DNA-binding PF00249.26 CCF35106.1 - 1.1e-11 44.5 2.6 2.9e-09 36.8 0.0 2.7 2 1 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CCF35106.1 - 1.8e-07 31.1 4.1 7.2e-05 22.8 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain CAP_GLY PF01302.20 CCF35108.1 - 1.7e-23 82.0 0.9 2.5e-23 81.5 0.6 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.1 CCF35108.1 - 1.5e-22 79.6 0.0 2.9e-22 78.7 0.0 1.5 2 0 0 2 2 2 1 Ubiquitin-like domain ubiquitin PF00240.18 CCF35108.1 - 0.00022 20.5 0.0 0.00054 19.3 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Acetyltransf_1 PF00583.19 CCF35109.1 - 0.00037 20.4 0.0 0.45 10.5 0.0 2.9 3 0 0 3 3 3 2 Acetyltransferase (GNAT) family CENP-I PF07778.6 CCF35110.1 - 1.4e-31 109.2 0.0 1.8e-31 108.9 0.0 1.0 1 0 0 1 1 1 1 Mis6 F-box-like PF12937.2 CCF35111.1 - 0.093 12.4 0.0 0.093 12.4 0.0 2.0 2 0 0 2 2 2 0 F-box-like RAMP4 PF06624.7 CCF35113.1 - 2.2e-07 30.3 0.3 3.1e-07 29.8 0.2 1.3 1 1 0 1 1 1 1 Ribosome associated membrane protein RAMP4 Mid1 PF12929.2 CCF35115.1 - 2.4e-132 441.7 4.2 2.8e-132 441.4 2.9 1.0 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component DUF3280 PF11684.3 CCF35115.1 - 0.11 12.7 0.1 0.2 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2380) Ras PF00071.17 CCF35117.1 - 1.6e-41 141.4 0.0 2.1e-41 141.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF35117.1 - 3.6e-08 33.9 0.0 7.6e-08 32.8 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 CCF35117.1 - 4e-06 26.1 0.0 5.5e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family PDZ PF00595.19 CCF35118.1 - 6.6e-07 29.4 0.0 1.1e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 CCF35118.1 - 3.7e-05 23.5 0.0 8e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.9 CCF35118.1 - 0.014 15.3 0.2 4.5 7.2 0.0 2.3 2 0 0 2 2 2 0 GRASP55/65 PDZ-like domain PWI PF01480.12 CCF35119.1 - 5.7e-30 103.2 0.0 8.1e-30 102.7 0.0 1.2 1 0 0 1 1 1 1 PWI domain Toxin_3 PF00537.13 CCF35120.1 - 0.00032 20.4 7.0 0.00053 19.8 4.9 1.4 1 0 0 1 1 1 1 Scorpion toxin-like domain Gamma-thionin PF00304.15 CCF35120.1 - 0.016 15.1 9.7 0.016 15.1 6.7 1.6 1 1 0 1 1 1 0 Gamma-thionin family Ecm33 PF12454.3 CCF35120.1 - 8.3 6.3 6.3 1.6 8.6 0.4 2.4 2 0 0 2 2 2 0 GPI-anchored cell wall organization protein adh_short PF00106.20 CCF35121.1 - 2e-23 83.1 0.4 2.6e-23 82.7 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF35121.1 - 2.5e-13 50.3 0.0 3.5e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF35121.1 - 6.6e-09 35.6 0.2 1.8e-08 34.2 0.1 1.7 1 1 0 1 1 1 1 KR domain MFS_1 PF07690.11 CCF35122.1 - 1.3e-38 132.6 53.2 1.8e-38 132.2 34.5 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF35122.1 - 6.1e-11 41.2 18.0 9.9e-11 40.5 12.4 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DHO_dh PF01180.16 CCF35123.1 - 7.5e-14 51.3 0.0 4.2e-13 48.9 0.0 1.8 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.10 CCF35123.1 - 0.017 14.3 1.8 0.025 13.7 1.2 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase MFS_1 PF07690.11 CCF35124.1 - 1.6e-12 46.7 43.9 2.4e-11 42.9 16.2 3.5 2 2 1 3 3 3 2 Major Facilitator Superfamily Glyco_transf_20 PF00982.16 CCF35125.1 - 1.5e-198 660.1 0.0 1.7e-198 659.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_transf_5 PF08323.6 CCF35125.1 - 0.027 13.9 0.1 0.094 12.1 0.0 1.9 2 0 0 2 2 2 0 Starch synthase catalytic domain PBP1_TM PF14812.1 CCF35126.1 - 0.009 16.2 1.8 0.009 16.2 1.2 5.2 4 2 2 6 6 6 1 Transmembrane domain of transglycosylase PBP1 at N-terminal MRP-S26 PF14943.1 CCF35126.1 - 0.026 14.0 0.9 0.026 14.0 0.6 2.6 3 0 0 3 3 3 0 Mitochondrial ribosome subunit S26 HCNGP PF07818.8 CCF35127.1 - 2.4e-22 78.7 0.0 3.5e-22 78.2 0.0 1.2 1 0 0 1 1 1 1 HCNGP-like protein DEAD PF00270.24 CCF35128.1 - 1.1e-43 148.6 0.0 7.7e-43 145.9 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF35128.1 - 9.9e-24 83.0 0.0 2.8e-23 81.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.1 CCF35129.1 - 0.0011 18.7 3.5 0.0011 18.7 2.4 3.3 3 0 0 3 3 3 2 Ring finger domain zf-RING_5 PF14634.1 CCF35129.1 - 0.016 14.9 1.1 0.016 14.9 0.8 2.9 3 0 0 3 3 3 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CCF35129.1 - 0.018 15.0 2.1 0.018 15.0 1.4 3.5 4 1 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) WD40 PF00400.27 CCF35130.1 - 1.1e-59 196.2 20.5 9.6e-13 47.4 0.4 8.1 7 1 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 CCF35130.1 - 9.2e-06 25.4 0.0 0.014 15.1 0.0 2.7 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 CCF35130.1 - 3.8e-05 22.6 0.2 0.0057 15.4 0.0 3.5 2 2 1 3 3 3 1 Nup133 N terminal like Nup160 PF11715.3 CCF35130.1 - 4.6e-05 21.7 7.5 0.018 13.1 0.0 4.2 4 1 1 5 5 5 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 CCF35130.1 - 0.00014 20.3 0.0 0.0068 14.7 0.0 2.4 2 1 0 2 2 2 1 Cytochrome D1 heme domain DUF3312 PF11768.3 CCF35130.1 - 0.034 12.3 0.0 0.69 8.0 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3312) Corona_nucleoca PF00937.13 CCF35130.1 - 0.23 10.3 16.7 0.37 9.7 11.6 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein VID27 PF08553.5 CCF35130.1 - 0.27 9.4 0.1 37 2.3 0.0 3.4 4 0 0 4 4 4 0 VID27 cytoplasmic protein Ribosomal_60s PF00428.14 CCF35130.1 - 3.4 8.1 22.0 0.04 14.3 2.4 2.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein Fungal_trans PF04082.13 CCF35131.1 - 6.4e-09 35.0 1.5 8.8e-09 34.6 1.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF35131.1 - 1.5e-08 34.4 10.9 2.3e-08 33.7 7.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mito_fiss_reg PF05308.6 CCF35131.1 - 0.47 9.7 11.1 0.75 9.1 7.7 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator DUF1772 PF08592.6 CCF35132.1 - 4.3e-13 49.2 0.1 5.3e-13 48.8 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) SpoIISB_antitox PF14185.1 CCF35132.1 - 0.098 12.4 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Antitoxin SpoIISB, type II toxin-antitoxin system ATG22 PF11700.3 CCF35133.1 - 0.013 13.9 2.0 0.017 13.6 1.4 1.1 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like DUF3112 PF11309.3 CCF35133.1 - 0.014 15.2 0.6 0.016 15.0 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) FtsX PF02687.16 CCF35133.1 - 0.026 14.2 1.1 0.035 13.8 0.7 1.1 1 0 0 1 1 1 0 FtsX-like permease family 5TM-5TMR_LYT PF07694.7 CCF35133.1 - 0.092 12.0 3.0 0.11 11.8 2.0 1.1 1 0 0 1 1 1 0 5TMR of 5TMR-LYT PP2C_2 PF13672.1 CCF35135.1 - 2.1e-05 24.0 0.1 3.4e-05 23.3 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 CCF35135.1 - 2.5e-05 24.0 0.0 0.0001 22.0 0.0 1.9 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.16 CCF35135.1 - 0.0059 16.0 0.1 0.13 11.6 0.0 2.1 1 1 1 2 2 2 1 Protein phosphatase 2C Fcf1 PF04900.7 CCF35136.1 - 2.1e-23 82.3 0.2 3.2e-23 81.7 0.1 1.3 1 0 0 1 1 1 1 Fcf1 C2 PF00168.25 CCF35137.1 - 0.00013 21.7 0.0 0.00027 20.7 0.0 1.6 1 0 0 1 1 1 1 C2 domain Oxidored_FMN PF00724.15 CCF35138.1 - 1.3e-70 238.0 0.0 1.5e-70 237.8 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family His_biosynth PF00977.16 CCF35138.1 - 0.13 11.5 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein Dus PF01207.12 CCF35138.1 - 0.26 10.0 0.5 0.46 9.2 0.0 1.6 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) DAO PF01266.19 CCF35139.1 - 8e-49 166.4 0.4 9.1e-49 166.2 0.3 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 CCF35139.1 - 6.6e-06 26.3 0.0 0.06 13.3 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF35139.1 - 0.00055 19.8 0.0 0.0014 18.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 CCF35139.1 - 0.0029 17.3 0.1 1.2 8.9 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 CCF35139.1 - 0.01 15.7 0.1 0.84 9.4 0.1 2.2 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF35139.1 - 0.02 13.7 0.0 0.072 11.9 0.0 1.8 2 0 0 2 2 2 0 FAD binding domain Pyr_redox PF00070.22 CCF35139.1 - 0.024 15.0 0.0 0.21 12.0 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 CCF35139.1 - 0.024 14.7 0.0 0.047 13.7 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.16 CCF35139.1 - 0.036 13.8 0.0 0.075 12.8 0.0 1.4 1 0 0 1 1 1 0 ThiF family TrkA_N PF02254.13 CCF35139.1 - 0.038 13.9 0.0 0.082 12.9 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Ldh_1_N PF00056.18 CCF35139.1 - 0.048 13.4 0.0 0.091 12.5 0.0 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain ApbA PF02558.11 CCF35139.1 - 0.058 12.8 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.17 CCF35139.1 - 0.06 12.1 0.3 0.22 10.3 0.0 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A Saccharop_dh PF03435.13 CCF35139.1 - 0.092 11.7 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase DUF4243 PF14027.1 CCF35140.1 - 8.6e-82 275.2 2.9 1e-81 274.9 2.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4243) Rad17 PF03215.10 CCF35141.1 - 7e-58 196.5 0.0 1.1e-57 195.8 0.0 1.3 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA PF00004.24 CCF35141.1 - 0.0018 18.4 0.0 0.0055 16.9 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 CCF35141.1 - 0.024 14.3 0.1 0.067 12.9 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA_22 PF13401.1 CCF35141.1 - 0.025 14.6 0.0 0.055 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 CCF35141.1 - 0.046 12.6 0.0 0.08 11.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.1 CCF35141.1 - 0.055 13.0 0.1 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain UPF0079 PF02367.12 CCF35141.1 - 0.1 12.2 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Cupin_3 PF05899.7 CCF35142.1 - 0.0022 17.3 0.0 0.023 14.0 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF861) HTH_OrfB_IS605 PF12323.3 CCF35143.1 - 0.097 12.0 0.1 0.27 10.6 0.1 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain FAM165 PF14981.1 CCF35144.1 - 6 6.4 8.9 11 5.6 6.2 1.4 1 0 0 1 1 1 0 FAM165 family Sulfatase PF00884.18 CCF35145.1 - 3.5e-57 193.9 0.0 4.4e-57 193.5 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Choline_sulf_C PF12411.3 CCF35145.1 - 2.4e-22 78.4 0.9 2.4e-22 78.4 0.6 2.4 2 1 1 3 3 3 1 Choline sulfatase enzyme C terminal Phosphodiest PF01663.17 CCF35145.1 - 2.5e-10 40.2 0.1 1.6e-09 37.5 0.1 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.13 CCF35145.1 - 0.029 13.7 0.0 0.6 9.4 0.0 2.3 2 0 0 2 2 2 0 Metalloenzyme superfamily DUF229 PF02995.12 CCF35145.1 - 0.075 11.4 0.0 0.11 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Tox-HDC PF15656.1 CCF35145.1 - 0.17 12.0 0.0 0.74 10.0 0.0 1.9 2 0 0 2 2 2 0 Toxin with a H, D/N and C signature Med8 PF10232.4 CCF35146.1 - 3e-26 92.3 1.1 4.7e-26 91.6 0.8 1.3 1 1 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 Calsarcin PF05556.6 CCF35146.1 - 0.12 11.5 0.1 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 Calcineurin-binding protein (Calsarcin) Fungal_trans PF04082.13 CCF35147.1 - 0.013 14.4 0.0 0.013 14.3 0.0 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain E1-E2_ATPase PF00122.15 CCF35148.1 - 2.1e-57 193.8 0.3 2.1e-57 193.8 0.2 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CCF35148.1 - 1.3e-45 155.1 5.7 1.3e-45 155.1 3.9 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CCF35148.1 - 4e-29 102.5 0.1 1.8e-28 100.4 0.1 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF35148.1 - 1.1e-19 70.1 0.0 2.2e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 CCF35148.1 - 2e-13 50.9 0.2 1.7e-12 47.9 0.1 2.4 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 CCF35148.1 - 8e-11 41.2 0.0 1.8e-09 36.9 0.0 2.9 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 CCF35148.1 - 1.3e-05 24.9 0.3 0.00036 20.1 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3325 PF11804.3 CCF35148.1 - 0.011 15.6 7.4 0.79 9.6 0.0 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF3325) Pox_T4_N PF04491.7 CCF35148.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Poxvirus T4 protein, N terminus Zn_clus PF00172.13 CCF35149.1 - 8.8e-08 31.9 14.3 1.8e-07 30.9 9.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF35149.1 - 2.4e-05 23.1 0.5 3.4e-05 22.6 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2797 PF10977.3 CCF35149.1 - 0.061 12.9 6.1 0.11 12.1 4.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) RTA1 PF04479.8 CCF35150.1 - 9.4e-54 182.2 9.2 1.3e-53 181.8 6.4 1.1 1 0 0 1 1 1 1 RTA1 like protein zf-C2H2 PF00096.21 CCF35154.1 - 1.9e-05 24.7 3.0 0.092 13.1 0.1 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF35154.1 - 0.00075 19.6 2.1 0.11 12.8 0.0 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CCF35154.1 - 0.019 15.0 1.4 2.9 8.1 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Axin_b-cat_bind PF08833.5 CCF35154.1 - 0.035 13.7 0.2 0.4 10.4 0.0 2.4 2 0 0 2 2 2 0 Axin beta-catenin binding domain zf-Di19 PF05605.7 CCF35154.1 - 0.054 13.6 1.2 3.5 7.8 0.2 2.3 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.1 CCF35154.1 - 0.21 11.5 3.0 4.2 7.4 0.0 2.4 1 1 1 2 2 2 0 C2H2-type zinc finger zf-CCHC_5 PF14787.1 CCF35154.1 - 8.3 5.9 8.4 53 3.4 0.0 3.4 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger Kinesin PF00225.18 CCF35156.1 - 1.4e-115 385.5 0.0 1.9e-115 385.1 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Herpes_UL14 PF03580.9 CCF35156.1 - 0.017 14.9 2.5 0.043 13.6 1.7 1.6 1 0 0 1 1 1 0 Herpesvirus UL14-like protein NmrA PF05368.8 CCF35157.1 - 4.1e-63 212.7 0.0 4.9e-63 212.4 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF35157.1 - 1.1e-15 58.0 0.0 1.6e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 CCF35157.1 - 3e-07 29.4 0.1 4.8e-07 28.7 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.13 CCF35157.1 - 0.0031 17.4 0.1 0.0068 16.4 0.1 1.6 1 0 0 1 1 1 1 TrkA-N domain Epimerase PF01370.16 CCF35157.1 - 0.024 14.0 0.1 0.049 13.0 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF2401 PF10287.4 CCF35159.1 - 4.2e-78 262.0 0.0 5.9e-78 261.5 0.0 1.2 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.4 CCF35159.1 - 2e-20 72.7 0.0 6.3e-20 71.1 0.0 1.9 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) Zip PF02535.17 CCF35159.1 - 0.13 11.2 0.2 0.17 10.8 0.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Big_3_4 PF13754.1 CCF35160.1 - 0.38 11.1 5.7 0.48 10.7 1.4 2.4 1 1 1 2 2 2 0 Bacterial Ig-like domain (group 3) Rap_GAP PF02145.10 CCF35162.1 - 2.6e-55 186.7 0.0 4.7e-55 185.8 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.11 CCF35162.1 - 9e-32 110.5 2.4 1.3e-28 100.0 0.3 2.4 2 0 0 2 2 2 2 Tuberin SGL PF08450.7 CCF35163.1 - 2.8e-23 82.5 0.1 3.8e-23 82.1 0.1 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Str_synth PF03088.11 CCF35163.1 - 3.1e-05 23.9 0.0 8.1e-05 22.5 0.0 1.7 1 1 0 1 1 1 1 Strictosidine synthase Arylesterase PF01731.15 CCF35163.1 - 0.0002 21.2 0.0 0.00057 19.8 0.0 1.8 1 0 0 1 1 1 1 Arylesterase Proteasome_A_N PF10584.4 CCF35164.1 - 0.0017 17.6 0.4 0.0053 16.0 0.0 2.1 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Alpha-amylase PF00128.19 CCF35165.1 - 2.5e-101 339.2 1.6 3.7e-101 338.6 1.1 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF3459 PF11941.3 CCF35165.1 - 0.00017 21.6 0.0 0.00035 20.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3459) hDGE_amylase PF14701.1 CCF35165.1 - 0.019 13.8 0.1 0.032 13.1 0.1 1.3 1 0 0 1 1 1 0 glucanotransferase domain of human glycogen debranching enzyme Herpes_gE PF02480.11 CCF35166.1 - 0.01 14.1 0.0 0.014 13.6 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Pkinase PF00069.20 CCF35169.1 - 5.2e-59 199.5 0.0 1e-58 198.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF35169.1 - 2.8e-33 115.0 0.0 1.4e-31 109.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 CCF35169.1 - 1.3e-05 24.3 0.0 9.5e-05 21.4 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 CCF35169.1 - 0.00024 20.9 0.1 0.00053 19.7 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Sybindin PF04099.7 CCF35170.1 - 2.9e-23 82.1 0.0 3.6e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.8 CCF35170.1 - 0.035 13.9 0.0 0.052 13.4 0.0 1.2 1 0 0 1 1 1 0 Sedlin, N-terminal conserved region Peroxin-3 PF04882.7 CCF35171.1 - 1.8e-144 481.6 0.0 2.1e-144 481.4 0.0 1.0 1 0 0 1 1 1 1 Peroxin-3 PI-PLC-X PF00388.14 CCF35172.1 - 5.4e-12 45.3 0.0 7.9e-12 44.7 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain Fungal_trans PF04082.13 CCF35173.1 - 1.5e-07 30.5 0.0 3.5e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Med15 PF09606.5 CCF35173.1 - 0.15 10.2 25.0 0.18 9.9 7.6 2.3 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Ctr PF04145.10 CCF35173.1 - 0.22 11.5 2.7 6.4 6.8 0.1 2.4 2 0 0 2 2 2 0 Ctr copper transporter family Pex14_N PF04695.8 CCF35173.1 - 1.6 8.7 16.7 2.3 8.2 0.6 2.6 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4140 PF13600.1 CCF35173.1 - 4.9 7.6 13.9 0.045 14.2 2.1 2.5 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Suf PF05843.9 CCF35173.1 - 5.2 6.7 13.1 3.2 7.3 2.4 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Peptidase_S49_N PF08496.5 CCF35173.1 - 6.9 6.4 7.7 12 5.7 1.2 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Pkinase PF00069.20 CCF35174.1 - 4.9e-47 160.2 0.0 7.7e-47 159.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF35174.1 - 3.6e-27 95.0 0.0 5.6e-27 94.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF35174.1 - 0.052 12.4 0.0 1.5 7.6 0.0 2.1 2 0 0 2 2 2 0 Kinase-like Abhydrolase_6 PF12697.2 CCF35175.1 - 6.7e-24 85.0 0.0 7.7e-24 84.8 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF35175.1 - 4.6e-10 39.4 0.1 5.4e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF35175.1 - 0.0011 18.5 0.0 0.003 17.1 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF900 PF05990.7 CCF35175.1 - 0.019 14.2 0.0 0.039 13.2 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) PFK PF00365.15 CCF35175.1 - 0.042 12.7 0.1 0.068 12.1 0.1 1.3 1 0 0 1 1 1 0 Phosphofructokinase AA_kinase PF00696.23 CCF35175.1 - 0.047 13.2 0.0 0.056 12.9 0.0 1.2 1 0 0 1 1 1 0 Amino acid kinase family PGAP1 PF07819.8 CCF35175.1 - 0.057 13.0 0.0 0.086 12.4 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein DUF676 PF05057.9 CCF35175.1 - 0.06 12.6 0.0 0.091 12.0 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_8 PF06259.7 CCF35175.1 - 0.1 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase NB-ARC PF00931.17 CCF35175.1 - 0.11 11.3 0.0 0.19 10.5 0.0 1.4 2 0 0 2 2 2 0 NB-ARC domain ADC PF06314.6 CCF35176.1 - 8.8e-05 21.9 0.0 0.00013 21.3 0.0 1.2 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) HET PF06985.6 CCF35177.1 - 1.3e-36 125.7 2.0 2.3e-36 124.9 1.4 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) WBS_methylT PF12589.3 CCF35178.1 - 1.1e-16 61.0 3.8 2.1e-16 60.1 2.6 1.5 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.7 CCF35178.1 - 1.6e-11 44.5 0.0 3.4e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF35178.1 - 9.3e-08 32.3 0.0 2e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF35178.1 - 7.6e-06 25.9 0.0 1.4e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF35178.1 - 1.1e-05 25.1 0.0 1.7e-05 24.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF35178.1 - 1.2e-05 25.6 0.0 4.1e-05 23.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF35178.1 - 6.2e-05 22.7 0.0 8.6e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF35178.1 - 8.5e-05 23.0 0.0 0.00019 22.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 CCF35178.1 - 0.00021 20.9 0.0 0.00035 20.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.15 CCF35178.1 - 0.0029 16.7 0.0 0.079 12.0 0.0 2.1 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 CCF35178.1 - 0.031 13.4 0.0 0.092 11.8 0.0 1.8 3 0 0 3 3 3 0 ubiE/COQ5 methyltransferase family DUF2264 PF10022.4 CCF35180.1 - 8.5e-122 406.2 0.3 1.1e-121 405.9 0.2 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) HMA PF00403.21 CCF35182.1 - 1.8e-11 43.9 0.0 3.4e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain Sod_Cu PF00080.15 CCF35182.1 - 3.3e-11 43.5 0.0 5.2e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Chordopox_RPO7 PF05864.7 CCF35182.1 - 0.12 12.4 0.3 2.2 8.4 0.0 2.2 2 0 0 2 2 2 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Ribosomal_L13 PF00572.13 CCF35183.1 - 7.2e-37 126.3 0.0 1.1e-36 125.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 Uricase PF01014.13 CCF35184.1 - 1.5e-85 284.2 0.2 6.3e-46 155.8 0.1 2.0 2 0 0 2 2 2 2 Uricase Lactonase PF10282.4 CCF35184.1 - 0.076 12.0 0.0 0.15 11.0 0.0 1.5 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller RICTOR_N PF14664.1 CCF35185.1 - 5.5e-138 459.5 7.1 5.1e-137 456.4 3.6 2.3 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.1 CCF35185.1 - 1.6e-86 289.0 0.5 1.3e-84 282.7 0.0 3.5 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, middle domain RasGEF_N_2 PF14663.1 CCF35185.1 - 1.9e-39 134.1 0.4 3.3e-38 130.1 0.0 2.8 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.1 CCF35185.1 - 4.1e-29 100.3 2.1 1.7e-27 95.1 0.1 4.0 5 0 0 5 5 4 1 Rapamycin-insensitive companion of mTOR, domain 5 HR1 PF02185.11 CCF35185.1 - 1.2e-14 53.8 6.7 2.1e-14 52.9 2.8 2.5 2 0 0 2 2 2 1 Hr1 repeat HEAT_2 PF13646.1 CCF35185.1 - 7.2e-05 22.9 2.2 0.38 11.0 0.0 5.3 5 1 1 6 6 6 2 HEAT repeats Uds1 PF15456.1 CCF35185.1 - 0.0033 17.3 5.1 0.011 15.6 3.5 1.9 1 0 0 1 1 1 1 Up-regulated During Septation IncA PF04156.9 CCF35185.1 - 0.0034 16.9 0.3 0.008 15.7 0.2 1.6 1 0 0 1 1 1 1 IncA protein DUF2443 PF10398.4 CCF35185.1 - 0.13 12.1 0.5 0.4 10.5 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) CENP-B_dimeris PF09026.5 CCF35185.1 - 0.75 10.0 4.4 2.1 8.6 3.1 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain zf-C4H2 PF10146.4 CCF35185.1 - 1.2 9.0 7.9 0.57 10.1 1.0 2.8 3 0 0 3 3 3 0 Zinc finger-containing protein Mnd1 PF03962.10 CCF35185.1 - 1.7 8.2 8.4 3.7 7.1 5.8 1.5 1 0 0 1 1 1 0 Mnd1 family Phos_pyr_kin PF08543.7 CCF35186.1 - 7.2e-86 287.3 0.5 8.3e-86 287.1 0.3 1.0 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.19 CCF35186.1 - 4.9e-12 45.5 0.1 7.6e-12 44.9 0.1 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Carb_kinase PF01256.12 CCF35186.1 - 0.04 13.1 2.3 0.12 11.6 1.6 1.9 1 1 0 1 1 1 0 Carbohydrate kinase E1_DerP2_DerF2 PF02221.10 CCF35186.1 - 0.049 13.8 0.0 0.082 13.1 0.0 1.3 1 0 0 1 1 1 0 ML domain HK PF02110.10 CCF35186.1 - 0.73 8.9 4.9 1.1 8.4 1.7 2.3 2 1 0 2 2 2 0 Hydroxyethylthiazole kinase family NUFIP1 PF10453.4 CCF35187.1 - 6.2e-08 32.0 0.0 2.1e-07 30.3 0.0 1.9 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-CCCH PF00642.19 CCF35187.1 - 0.11 12.1 5.8 0.25 11.0 4.0 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) CASP_C PF08172.7 CCF35187.1 - 2.7 6.9 8.0 0.95 8.4 1.2 2.4 2 0 0 2 2 2 0 CASP C terminal RNA_pol_Rbc25 PF08292.7 CCF35188.1 - 5.2e-34 117.0 0.0 7e-34 116.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.12 CCF35188.1 - 6.9e-14 51.7 0.0 1e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 DUF106 PF01956.11 CCF35189.1 - 1.8e-55 187.0 0.7 2.2e-55 186.7 0.5 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF106 Cytochrom_B_N PF00033.14 CCF35189.1 - 0.14 11.4 0.1 0.14 11.4 0.0 2.1 2 1 0 2 2 2 0 Cytochrome b(N-terminal)/b6/petB SPC25 PF06703.6 CCF35190.1 - 6e-53 178.7 0.1 7.2e-53 178.4 0.0 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) Lactamase_B_2 PF12706.2 CCF35191.1 - 0.0046 16.5 0.0 0.0063 16.0 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 CCF35191.1 - 0.035 13.8 0.0 0.061 13.0 0.0 1.6 1 0 0 1 1 1 0 Beta-lactamase superfamily domain MFS_1 PF07690.11 CCF35192.1 - 2.2e-20 72.6 13.0 2.2e-20 72.6 9.0 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Polyketide_cyc PF03364.15 CCF35194.1 - 3.2e-27 95.0 0.1 8.1e-27 93.7 0.1 1.7 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.4 CCF35194.1 - 2.9e-06 27.5 1.6 8.1e-06 26.0 1.1 1.7 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport SNF5 PF04855.7 CCF35197.1 - 3.9e-84 281.9 0.0 5.3e-84 281.4 0.0 1.1 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 GATA PF00320.22 CCF35197.1 - 0.0026 17.0 2.5 0.0068 15.7 1.7 1.8 1 0 0 1 1 1 1 GATA zinc finger Myticin-prepro PF10690.4 CCF35199.1 - 0.37 10.8 2.7 0.43 10.6 1.9 1.2 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel HEAT_2 PF13646.1 CCF35200.1 - 0.0011 19.2 6.5 1.3 9.3 0.0 5.1 6 0 0 6 6 6 2 HEAT repeats HEAT PF02985.17 CCF35200.1 - 0.004 17.0 3.5 6.3 7.1 0.2 5.4 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.1 CCF35200.1 - 5.1 7.7 9.4 34 5.0 0.1 5.0 5 0 0 5 5 5 0 HEAT-like repeat AA_permease PF00324.16 CCF35201.1 - 2.4e-94 316.3 31.6 2.8e-94 316.1 21.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF35201.1 - 4.3e-25 88.1 33.4 5.2e-25 87.8 23.1 1.0 1 0 0 1 1 1 1 Amino acid permease 2-Hacid_dh_C PF02826.14 CCF35202.1 - 4.2e-46 156.3 0.0 2.4e-33 114.7 0.0 2.1 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 CCF35202.1 - 0.00035 20.0 0.0 0.00042 19.7 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 CCF35202.1 - 0.0024 17.7 0.0 0.0039 17.0 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NUDIX PF00293.23 CCF35203.1 - 1e-07 31.6 0.0 1.2e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain SR-25 PF10500.4 CCF35204.1 - 0.0068 15.9 14.0 0.01 15.3 9.7 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein SOBP PF15279.1 CCF35204.1 - 0.2 12.0 5.5 0.27 11.5 3.8 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF305 PF03713.8 CCF35204.1 - 0.36 10.6 3.3 0.66 9.7 2.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF305) Ycf1 PF05758.7 CCF35204.1 - 1.2 6.7 5.7 1.4 6.5 4.0 1.0 1 0 0 1 1 1 0 Ycf1 SRP-alpha_N PF04086.8 CCF35204.1 - 1.3 8.3 13.6 1.8 7.9 9.4 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RR_TM4-6 PF06459.7 CCF35204.1 - 1.3 8.8 10.3 2 8.2 7.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2413 PF10310.4 CCF35204.1 - 2.9 6.6 13.8 3.7 6.2 9.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Vfa1 PF08432.5 CCF35204.1 - 6.1 6.8 18.9 9.8 6.1 13.1 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Pox_Ag35 PF03286.9 CCF35204.1 - 9.4 5.6 16.3 14 5.1 11.3 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PDR_CDR PF06422.7 CCF35205.1 - 0.018 14.6 3.4 0.031 13.9 2.3 1.5 1 1 0 1 1 1 0 CDR ABC transporter ABC2_membrane PF01061.19 CCF35205.1 - 0.1 11.7 1.1 0.39 9.8 0.1 2.0 2 0 0 2 2 2 0 ABC-2 type transporter Chitin_synth_1 PF01644.12 CCF35206.1 - 6.3e-70 234.1 0.0 9.2e-70 233.6 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_2 PF03142.10 CCF35206.1 - 7e-28 97.3 0.0 2.5e-22 78.9 0.0 2.3 2 0 0 2 2 2 2 Chitin synthase Chitin_synth_1N PF08407.6 CCF35206.1 - 1.1e-26 92.3 0.1 2.2e-26 91.3 0.0 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Glyco_trans_2_3 PF13632.1 CCF35206.1 - 2.2e-10 40.5 0.1 2.2e-10 40.5 0.0 2.3 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 CCF35206.1 - 1.8e-08 34.4 0.0 3.6e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Hist_deacetyl PF00850.14 CCF35208.1 - 1.5e-61 208.4 0.1 2.2e-61 207.8 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain RTP801_C PF07809.6 CCF35208.1 - 0.044 13.4 0.0 0.089 12.4 0.0 1.4 1 0 0 1 1 1 0 RTP801 C-terminal region DUF999 PF06198.6 CCF35208.1 - 0.45 10.3 0.0 0.94 9.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF999) TGT PF01702.13 CCF35209.1 - 3.4e-84 281.8 0.0 4.4e-84 281.4 0.0 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Mit_ribos_Mrp51 PF11709.3 CCF35210.1 - 1.5e-82 277.3 0.0 1.8e-82 277.0 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit Ribosomal_S17e PF00833.13 CCF35211.1 - 7.9e-58 193.5 0.5 9.9e-58 193.2 0.3 1.0 1 0 0 1 1 1 1 Ribosomal S17 Cryptochrome_C PF12546.3 CCF35211.1 - 0.01 16.5 0.0 0.014 16.0 0.0 1.2 1 0 0 1 1 1 0 Blue/Ultraviolet sensing protein C terminal RPAP2_Rtr1 PF04181.8 CCF35212.1 - 6.2e-20 71.0 0.1 1.1e-19 70.2 0.0 1.4 1 0 0 1 1 1 1 Rtr1/RPAP2 family SH3_1 PF00018.23 CCF35213.1 - 5.2e-09 35.3 0.1 7.9e-09 34.7 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 CCF35213.1 - 6.8e-08 31.8 0.0 1.1e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 CCF35213.1 - 3.3e-07 29.7 0.1 5.2e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain p450 PF00067.17 CCF35216.1 - 4.5e-34 117.7 0.0 5.2e-34 117.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FSH1 PF03959.8 CCF35217.1 - 9.8e-29 100.3 0.0 1.2e-28 100.0 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 CCF35217.1 - 0.092 12.5 0.0 0.14 11.8 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family p450 PF00067.17 CCF35218.1 - 1.9e-51 175.0 0.0 2.3e-51 174.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ketoacyl-synt PF00109.21 CCF35219.1 - 1.5e-74 250.6 0.1 2e-74 250.2 0.1 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.18 CCF35219.1 - 1.7e-06 27.2 0.1 2.5e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Ketoacyl-synt_C PF02801.17 CCF35219.1 - 1.9e-05 24.4 0.0 4.6e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain SET PF00856.23 CCF35220.1 - 8.9e-08 32.5 0.0 3.7e-07 30.5 0.0 2.1 2 0 0 2 2 2 1 SET domain PRP21_like_P PF12230.3 CCF35220.1 - 1.3 8.5 11.1 0.49 9.8 1.6 2.5 2 0 0 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein Ribosomal_L14 PF00238.14 CCF35221.1 - 2.8e-43 146.5 1.5 3.1e-43 146.4 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e TFIIS_C PF01096.13 CCF35222.1 - 3.8e-17 61.6 3.1 4.1e-17 61.5 2.2 1.0 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Lar_restr_allev PF14354.1 CCF35222.1 - 9.3e-05 22.6 2.6 0.00011 22.4 1.8 1.0 1 0 0 1 1 1 1 Restriction alleviation protein Lar Ogr_Delta PF04606.7 CCF35222.1 - 0.0018 17.8 0.6 0.0023 17.5 0.4 1.2 1 0 0 1 1 1 1 Ogr/Delta-like zinc finger A2L_zn_ribbon PF08792.5 CCF35222.1 - 0.019 14.3 5.2 0.28 10.7 1.7 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-RING_2 PF13639.1 CCF35222.1 - 0.21 11.4 4.4 4.8 7.0 0.5 2.2 2 0 0 2 2 2 0 Ring finger domain Zn-ribbon_8 PF09723.5 CCF35222.1 - 0.22 11.5 7.4 4.2 7.4 1.8 2.2 2 0 0 2 2 2 0 Zinc ribbon domain zf-RING_5 PF14634.1 CCF35222.1 - 0.26 11.0 3.9 4.5 7.0 0.3 2.2 2 0 0 2 2 2 0 zinc-RING finger domain RRN7 PF11781.3 CCF35222.1 - 0.61 9.6 9.1 4.7 6.8 0.1 2.2 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 TF_Zn_Ribbon PF08271.7 CCF35222.1 - 0.7 9.2 6.2 3.2 7.1 4.3 1.9 1 1 0 1 1 1 0 TFIIB zinc-binding Zn_Tnp_IS1595 PF12760.2 CCF35222.1 - 1 9.2 4.4 2.5 7.9 3.1 1.6 1 1 0 1 1 1 0 Transposase zinc-ribbon domain zf-C3HC4_2 PF13923.1 CCF35222.1 - 1.1 9.2 5.8 8 6.5 0.4 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF35222.1 - 2.9 7.6 7.4 26 4.5 4.9 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C2H2_4 PF13894.1 CCF35222.1 - 3.1 8.3 5.1 31 5.2 0.1 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger UPF0547 PF10571.4 CCF35222.1 - 3.8 7.2 10.3 8.1 6.2 0.4 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Rubredoxin PF00301.15 CCF35222.1 - 7.8 6.4 7.1 10 6.1 0.1 2.2 2 0 0 2 2 2 0 Rubredoxin IF-2B PF01008.12 CCF35223.1 - 1.2e-42 145.8 0.0 1.4e-42 145.6 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family Rubella_E1 PF05748.6 CCF35223.1 - 0.033 12.8 0.0 0.042 12.4 0.0 1.1 1 0 0 1 1 1 0 Rubella membrane glycoprotein E1 TRAPPC10 PF12584.3 CCF35224.1 - 1.1e-22 80.1 0.0 2.2e-22 79.1 0.0 1.5 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Foie-gras_1 PF11817.3 CCF35224.1 - 0.023 14.2 0.1 0.037 13.4 0.1 1.3 1 0 0 1 1 1 0 Foie gras liver health family 1 Mito_carr PF00153.22 CCF35226.1 - 1e-06 28.3 0.1 1.1e-06 28.2 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein Bd3614_N PF14442.1 CCF35227.1 - 6.4 6.7 6.7 6.8 6.6 4.6 1.3 1 1 0 1 1 1 0 Bd3614-like deaminase N-terminal SUR7 PF06687.7 CCF35231.1 - 7.8e-35 120.3 14.0 1e-34 119.9 9.7 1.2 1 0 0 1 1 1 1 SUR7/PalI family DUF3353 PF11833.3 CCF35231.1 - 6.9 6.0 13.0 2.5 7.5 7.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3353) X_fast-SP_rel PF06669.6 CCF35232.1 - 0.065 13.1 3.8 0.14 12.1 2.6 1.5 1 0 0 1 1 1 0 Xylella fastidiosa surface protein related GST_N_3 PF13417.1 CCF35233.1 - 3.6e-23 81.5 0.0 8e-23 80.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 CCF35233.1 - 5.4e-15 55.1 0.1 2.1e-14 53.2 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 CCF35233.1 - 4.2e-07 29.7 0.1 7.4e-07 28.9 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 CCF35233.1 - 0.00037 20.4 0.0 0.00079 19.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 CCF35233.1 - 0.034 14.6 0.1 0.069 13.6 0.0 1.5 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Pro_dh PF01619.13 CCF35234.1 - 7.5e-38 130.2 0.0 1e-37 129.7 0.0 1.2 1 0 0 1 1 1 1 Proline dehydrogenase P5CR_dimer PF14748.1 CCF35235.1 - 3.3e-27 94.5 1.7 5e-27 94.0 0.4 1.9 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.12 CCF35235.1 - 6e-11 42.6 0.1 1.3e-10 41.5 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.18 CCF35235.1 - 0.0042 16.8 0.1 0.01 15.5 0.1 1.6 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pkinase PF00069.20 CCF35236.1 - 2.4e-06 26.9 0.0 2.4e-06 26.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF35236.1 - 0.0025 16.9 0.0 0.0025 16.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.11 CCF35236.1 - 0.019 14.9 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 ABC1 family MFS_1 PF07690.11 CCF35238.1 - 4.2e-24 84.9 16.9 4.2e-24 84.9 11.7 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF35238.1 - 8.2e-09 34.5 22.3 0.00012 20.7 0.4 3.3 2 1 1 3 3 3 3 Sugar (and other) transporter Neurensin PF14927.1 CCF35238.1 - 0.18 11.1 2.8 0.84 9.0 0.6 2.7 2 1 0 2 2 2 0 Neurensin AMP-binding PF00501.23 CCF35240.1 - 1.9e-83 280.1 0.0 3e-63 213.6 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.15 CCF35240.1 - 5e-61 206.1 0.0 8.6e-61 205.4 0.0 1.3 1 0 0 1 1 1 1 Condensation domain HxxPF_rpt PF13745.1 CCF35240.1 - 4.1e-23 81.5 0.0 1.4e-22 79.7 0.0 2.0 1 0 0 1 1 1 1 HxxPF-repeated domain AMP-binding_C PF13193.1 CCF35240.1 - 2.8e-13 50.6 0.5 8.5e-06 26.6 0.0 3.6 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain PP-binding PF00550.20 CCF35240.1 - 9.7e-13 48.1 0.2 2.5e-12 46.8 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_23 PF13489.1 CCF35240.1 - 0.00047 19.9 0.0 0.0056 16.4 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF35240.1 - 0.0051 17.3 0.0 0.022 15.3 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain AATase PF07247.7 CCF35240.1 - 0.9 8.0 0.0 1.6 7.2 0.0 1.3 1 0 0 1 1 1 0 Alcohol acetyltransferase AMP-binding PF00501.23 CCF35241.1 - 4.4e-262 868.6 17.6 1.1e-86 290.8 0.1 5.2 4 1 1 5 5 5 5 AMP-binding enzyme Condensation PF00668.15 CCF35241.1 - 3e-185 614.0 6.4 3.8e-62 209.8 0.2 3.6 4 0 0 4 4 4 3 Condensation domain HxxPF_rpt PF13745.1 CCF35241.1 - 8.8e-69 227.8 0.4 4.7e-22 78.1 0.0 4.4 4 0 0 4 4 4 3 HxxPF-repeated domain AMP-binding_C PF13193.1 CCF35241.1 - 2.1e-44 150.2 8.7 1.1e-14 55.1 0.3 5.3 4 0 0 4 4 4 4 AMP-binding enzyme C-terminal domain PP-binding PF00550.20 CCF35241.1 - 1.3e-39 134.3 2.2 2.3e-12 46.9 0.0 4.2 3 0 0 3 3 3 3 Phosphopantetheine attachment site AATase PF07247.7 CCF35241.1 - 4.8e-06 25.4 0.0 1.2 7.6 0.0 3.2 3 0 0 3 3 3 3 Alcohol acetyltransferase DUF4115 PF13464.1 CCF35241.1 - 0.01 15.4 0.0 1.6 8.4 0.0 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4115) GH3 PF03321.8 CCF35241.1 - 0.067 11.7 0.5 9.7 4.5 0.0 3.5 4 0 0 4 4 4 0 GH3 auxin-responsive promoter Viral_P18 PF04521.8 CCF35241.1 - 0.36 10.2 0.1 93 2.4 0.0 3.2 3 0 0 3 3 3 0 ssRNA positive strand viral 18kD cysteine rich protein Prp31_C PF09785.4 CCF35242.1 - 1.3e-44 151.5 1.5 1.3e-44 151.5 1.0 1.8 2 0 0 2 2 2 1 Prp31 C terminal domain Nop PF01798.13 CCF35242.1 - 2.2e-40 137.3 0.0 4.2e-40 136.4 0.0 1.5 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 CCF35242.1 - 6.2e-21 73.9 0.2 1.7e-20 72.5 0.1 1.8 2 0 0 2 2 2 1 NOSIC (NUC001) domain HAT PF02184.11 CCF35243.1 - 1.5e-22 79.0 76.5 1.6e-12 46.9 1.5 12.8 15 0 0 15 15 14 5 HAT (Half-A-TPR) repeat TPR_14 PF13428.1 CCF35243.1 - 1.3e-21 75.1 30.7 4.4e-05 23.7 0.1 11.1 8 3 5 13 13 12 6 Tetratricopeptide repeat TPR_16 PF13432.1 CCF35243.1 - 3.8e-18 65.6 26.6 0.0017 18.9 0.1 8.5 8 2 0 9 9 7 5 Tetratricopeptide repeat TPR_19 PF14559.1 CCF35243.1 - 7.9e-18 64.5 2.7 9.3e-05 22.6 0.0 6.9 7 0 0 7 7 6 3 Tetratricopeptide repeat Suf PF05843.9 CCF35243.1 - 4.5e-17 62.7 16.9 0.00012 21.9 0.1 6.2 3 1 3 6 6 6 5 Suppressor of forked protein (Suf) TPR_15 PF13429.1 CCF35243.1 - 2.5e-07 30.0 16.7 0.021 13.9 0.2 6.0 2 1 5 7 7 7 4 Tetratricopeptide repeat NRDE-2 PF08424.5 CCF35243.1 - 3e-06 26.3 21.6 0.022 13.6 0.1 6.1 3 2 0 3 3 3 3 NRDE-2, necessary for RNA interference TPR_2 PF07719.12 CCF35243.1 - 3.9e-05 23.2 25.8 0.043 13.7 0.0 9.0 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_12 PF13424.1 CCF35243.1 - 0.00097 19.0 26.9 0.018 14.9 0.1 8.2 9 2 0 9 9 9 2 Tetratricopeptide repeat U3_assoc_6 PF08640.6 CCF35243.1 - 0.001 18.8 30.0 0.0084 15.8 0.9 6.9 6 2 2 8 8 7 2 U3 small nucleolar RNA-associated protein 6 Fis1_TPR_C PF14853.1 CCF35243.1 - 0.0047 16.7 11.7 7.1 6.5 0.6 6.1 7 0 0 7 7 7 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 CCF35243.1 - 0.0065 16.8 27.6 1.1 9.8 0.0 8.8 10 1 1 11 11 9 1 Tetratricopeptide repeat TPR_17 PF13431.1 CCF35243.1 - 0.011 15.9 9.0 11 6.4 0.0 6.5 8 0 0 8 8 6 0 Tetratricopeptide repeat TPR_8 PF13181.1 CCF35243.1 - 0.012 15.3 3.2 42 4.2 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.1 CCF35243.1 - 0.017 14.7 15.7 0.89 9.2 0.0 6.5 6 2 2 8 8 8 0 TPR repeat TPR_9 PF13371.1 CCF35243.1 - 0.042 13.7 8.2 1.5 8.7 0.0 4.7 4 2 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 CCF35243.1 - 0.12 12.2 19.7 14 5.8 0.0 7.2 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_1 PF00515.23 CCF35243.1 - 0.14 11.8 8.3 12 5.6 0.0 4.9 6 0 0 6 6 4 0 Tetratricopeptide repeat c-SKI_SMAD_bind PF08782.5 CCF35243.1 - 0.67 10.1 6.7 3.3 7.8 0.0 4.2 4 0 0 4 4 4 0 c-SKI Smad4 binding domain LAP1C PF05609.7 CCF35244.1 - 0.027 13.1 4.6 0.042 12.5 3.2 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) La PF05383.12 CCF35246.1 - 1.8e-16 59.6 0.0 2.8e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 La domain stn_TNFRSF12A PF12191.3 CCF35247.1 - 0.095 12.7 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain peroxidase PF00141.18 CCF35248.1 - 1.4e-29 103.2 0.0 2.2e-29 102.5 0.0 1.3 1 0 0 1 1 1 1 Peroxidase Abhydrolase_3 PF07859.8 CCF35249.1 - 1.2e-40 139.4 0.0 2.6e-31 108.8 0.0 2.7 2 0 0 2 2 2 2 alpha/beta hydrolase fold DUF2424 PF10340.4 CCF35249.1 - 5.2e-14 51.6 0.0 1.1e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 CCF35249.1 - 0.00056 19.6 0.0 0.0012 18.6 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family COesterase PF00135.23 CCF35249.1 - 0.00076 18.3 0.2 0.023 13.4 0.0 2.2 2 0 0 2 2 2 1 Carboxylesterase family WGG PF10273.4 CCF35250.1 - 4e-31 106.9 0.8 1.8e-30 104.8 0.1 2.0 2 0 0 2 2 2 1 Pre-rRNA-processing protein TSR2 RRP7 PF12923.2 CCF35250.1 - 0.021 14.8 2.1 0.024 14.6 0.1 2.0 1 1 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) BSD PF03909.12 CCF35251.1 - 2e-15 56.2 0.1 4.1e-15 55.2 0.1 1.5 1 0 0 1 1 1 1 BSD domain Sigma70_r2 PF04542.9 CCF35251.1 - 0.011 15.3 0.6 0.027 14.0 0.0 1.9 2 0 0 2 2 2 0 Sigma-70 region 2 Suf PF05843.9 CCF35251.1 - 0.24 11.1 8.0 0.039 13.6 1.3 2.3 2 1 0 2 2 2 0 Suppressor of forked protein (Suf) SOG2 PF10428.4 CCF35251.1 - 4.9 5.6 17.2 3.1 6.3 0.6 2.3 2 0 0 2 2 2 0 RAM signalling pathway protein PilM PF07419.7 CCF35252.1 - 0.092 12.2 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 PilM RRM_6 PF14259.1 CCF35252.1 - 0.11 12.4 0.1 3 7.8 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) E1-E2_ATPase PF00122.15 CCF35254.1 - 4.3e-48 163.3 8.0 8.4e-48 162.4 5.6 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 CCF35254.1 - 6.5e-29 101.8 1.6 1.6e-28 100.6 1.1 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 CCF35254.1 - 7.3e-11 42.5 0.0 1.6e-10 41.5 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 CCF35254.1 - 1.9e-09 37.4 0.1 2.9e-08 33.7 0.0 2.6 2 0 0 2 2 2 1 Heavy-metal-associated domain Hydrolase_3 PF08282.7 CCF35254.1 - 0.14 11.7 0.9 9.7 5.6 0.1 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase PT PF04886.7 CCF35256.1 - 0.0031 16.7 8.0 0.0076 15.5 5.6 1.6 1 0 0 1 1 1 1 PT repeat ORC6 PF05460.8 CCF35256.1 - 0.025 13.7 3.7 0.029 13.4 2.6 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) PQ-loop PF04193.9 CCF35257.1 - 2.2e-17 62.3 4.5 1.9e-12 46.5 0.7 2.7 2 0 0 2 2 2 2 PQ loop repeat SH3_1 PF00018.23 CCF35259.1 - 2e-16 59.0 0.1 3.9e-16 58.1 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 CCF35259.1 - 6.3e-15 54.4 0.2 1.2e-14 53.5 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 CCF35259.1 - 6.8e-14 51.1 0.1 1.3e-13 50.1 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.21 CCF35259.1 - 0.018 14.9 0.0 0.042 13.7 0.0 1.6 1 0 0 1 1 1 0 WW domain Hemerythrin PF01814.18 CCF35263.1 - 0.032 14.3 0.0 0.04 14.0 0.0 1.1 1 0 0 1 1 1 0 Hemerythrin HHE cation binding domain CFEM PF05730.6 CCF35264.1 - 1e-09 38.0 8.3 1.4e-09 37.6 5.7 1.2 1 0 0 1 1 1 1 CFEM domain Peroxidase_2 PF01328.12 CCF35265.1 - 1.1e-44 152.4 0.1 1.4e-44 152.0 0.1 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 Clat_adaptor_s PF01217.15 CCF35266.1 - 2.4e-05 24.0 0.0 2.5e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF4536 PF15055.1 CCF35267.1 - 6e-05 23.0 2.2 9.5e-05 22.3 1.5 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4536) ECR1_N PF14382.1 CCF35268.1 - 6.9e-13 47.6 0.2 1.4e-12 46.6 0.1 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.4 CCF35268.1 - 0.00057 19.7 0.2 0.0053 16.6 0.2 2.5 1 1 0 1 1 1 1 Exosome component EXOSC1/CSL4 Aldo_ket_red PF00248.16 CCF35269.1 - 2e-09 36.7 0.0 2.8e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Clat_adaptor_s PF01217.15 CCF35270.1 - 5e-43 146.2 1.3 5.6e-43 146.0 0.9 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Glyco_hydro_18 PF00704.23 CCF35271.1 - 5.4e-66 223.3 0.4 8.7e-66 222.7 0.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF1375 PF07119.7 CCF35272.1 - 0.15 11.8 1.3 4.4 7.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1375) Mpv17_PMP22 PF04117.7 CCF35273.1 - 1.1e-13 50.5 5.6 2e-13 49.7 3.7 1.6 1 1 0 1 1 1 1 Mpv17 / PMP22 family CFEM PF05730.6 CCF35274.1 - 9.2e-10 38.2 3.6 1.6e-09 37.4 2.5 1.4 1 0 0 1 1 1 1 CFEM domain DUF3439 PF11921.3 CCF35274.1 - 1.7 8.3 9.8 1.6 8.5 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) DUF843 PF05814.6 CCF35276.1 - 2.4 7.9 5.6 3.4 7.5 1.3 2.4 1 1 1 2 2 2 0 Baculovirus protein of unknown function (DUF843) OAD_gamma PF04277.8 CCF35276.1 - 5.1 7.5 9.7 1.3 9.4 3.7 2.2 2 2 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain UCR_14kD PF02271.11 CCF35277.1 - 9.8e-43 144.2 0.1 1.1e-42 143.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Anp1 PF03452.9 CCF35278.1 - 8.5e-107 356.3 0.0 1e-106 356.0 0.0 1.0 1 0 0 1 1 1 1 Anp1 ABC_tran PF00005.22 CCF35279.1 - 6.2e-49 165.8 0.1 8.5e-27 94.1 0.0 4.0 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 CCF35279.1 - 5.7e-14 52.7 6.4 2.6e-06 27.6 0.6 4.1 2 2 0 3 3 3 3 AAA domain SMC_N PF02463.14 CCF35279.1 - 1.8e-12 46.9 0.0 4.3e-05 22.8 0.0 3.9 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 CCF35279.1 - 6.2e-08 33.2 1.7 0.00088 19.6 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.1 CCF35279.1 - 1.3e-07 31.0 0.5 0.0064 16.0 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain Chromo PF00385.19 CCF35279.1 - 3.5e-07 29.7 0.4 9e-07 28.4 0.3 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DUF258 PF03193.11 CCF35279.1 - 5.2e-07 29.0 0.0 0.0016 17.6 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 CCF35279.1 - 1.2e-06 29.3 0.2 0.027 15.3 0.0 3.3 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.18 CCF35279.1 - 1.5e-06 28.1 0.0 0.015 15.2 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.1 CCF35279.1 - 1.5e-06 28.3 0.0 0.041 14.0 0.0 3.6 3 0 0 3 3 3 2 AAA domain AAA_15 PF13175.1 CCF35279.1 - 4.7e-06 25.8 0.5 0.064 12.2 0.0 3.5 4 0 0 4 4 3 1 AAA ATPase domain Miro PF08477.8 CCF35279.1 - 1.5e-05 25.4 0.1 0.039 14.4 0.1 3.1 2 1 0 2 2 2 1 Miro-like protein SbcCD_C PF13558.1 CCF35279.1 - 1.8e-05 24.5 0.0 0.46 10.4 0.0 3.3 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_10 PF12846.2 CCF35279.1 - 4.8e-05 22.9 1.1 0.81 9.0 0.1 3.7 4 0 0 4 4 4 2 AAA-like domain NACHT PF05729.7 CCF35279.1 - 0.00012 21.7 0.2 0.15 11.7 0.0 2.9 3 0 0 3 3 2 1 NACHT domain MobB PF03205.9 CCF35279.1 - 0.00013 21.6 0.1 0.19 11.4 0.1 2.6 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 CCF35279.1 - 0.00025 20.9 0.5 0.48 10.2 0.0 3.0 3 0 0 3 3 2 2 AAA domain HEAT_2 PF13646.1 CCF35279.1 - 0.00026 21.1 5.2 0.18 12.0 0.3 3.9 3 1 1 4 4 3 2 HEAT repeats AAA_28 PF13521.1 CCF35279.1 - 0.00036 20.5 0.0 0.032 14.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 CCF35279.1 - 0.00047 20.4 0.2 0.099 12.9 0.0 3.0 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 CCF35279.1 - 0.00077 18.3 0.4 0.21 10.3 0.1 2.5 2 0 0 2 2 2 1 ArgK protein RNA_helicase PF00910.17 CCF35279.1 - 0.0008 19.5 0.0 2.2 8.5 0.0 2.6 2 0 0 2 2 2 2 RNA helicase DUF87 PF01935.12 CCF35279.1 - 0.00092 19.0 3.4 0.61 9.8 0.1 4.2 4 0 0 4 4 4 1 Domain of unknown function DUF87 AAA_25 PF13481.1 CCF35279.1 - 0.0033 16.8 0.0 2.2 7.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 CCF35279.1 - 0.0091 16.2 0.0 4.5 7.4 0.0 3.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) CLASP_N PF12348.3 CCF35279.1 - 0.0093 15.3 0.0 0.039 13.3 0.0 2.0 2 0 0 2 2 2 1 CLASP N terminal DUF815 PF05673.8 CCF35279.1 - 0.011 14.7 0.0 1.4 7.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Dynamin_N PF00350.18 CCF35279.1 - 0.011 15.5 0.0 0.34 10.7 0.0 2.8 2 0 0 2 2 2 0 Dynamin family PduV-EutP PF10662.4 CCF35279.1 - 0.013 14.9 0.0 1.1 8.7 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.1 CCF35279.1 - 0.014 14.9 0.6 5.8 6.4 0.1 3.1 3 0 0 3 3 2 0 AAA domain AAA_14 PF13173.1 CCF35279.1 - 0.017 15.0 0.0 5.9 6.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain Septin PF00735.13 CCF35279.1 - 0.025 13.5 0.0 8 5.3 0.0 2.5 2 0 0 2 2 2 0 Septin FtsK_SpoIIIE PF01580.13 CCF35279.1 - 0.025 14.0 0.9 4.2 6.7 0.0 3.0 3 0 0 3 3 3 0 FtsK/SpoIIIE family Arch_ATPase PF01637.13 CCF35279.1 - 0.028 14.1 0.0 3.6 7.2 0.0 2.6 2 0 0 2 2 2 0 Archaeal ATPase AAA_13 PF13166.1 CCF35279.1 - 0.056 11.9 3.4 2.8 6.3 0.0 2.5 3 0 0 3 3 2 0 AAA domain AAA_16 PF13191.1 CCF35279.1 - 0.07 13.1 1.6 4.8 7.1 0.1 3.5 3 0 0 3 3 3 0 AAA ATPase domain HEAT PF02985.17 CCF35279.1 - 0.086 12.9 2.3 67 3.9 0.0 4.9 5 0 0 5 5 3 0 HEAT repeat MutS_V PF00488.16 CCF35279.1 - 0.094 12.1 0.2 7.4 5.9 0.0 2.3 2 0 0 2 2 2 0 MutS domain V HSP70 PF00012.15 CCF35280.1 - 3.5e-11 41.7 0.3 1.4e-09 36.4 0.1 2.0 2 0 0 2 2 2 2 Hsp70 protein zf-SAP30 PF13866.1 CCF35280.1 - 0.004 16.7 0.1 0.0091 15.6 0.1 1.5 1 0 0 1 1 1 1 SAP30 zinc-finger MreB_Mbl PF06723.8 CCF35280.1 - 0.0097 14.5 0.1 0.051 12.1 0.0 1.9 2 0 0 2 2 2 1 MreB/Mbl protein Thaumatin PF00314.12 CCF35281.1 - 7.1e-70 234.7 4.5 9.7e-70 234.3 3.1 1.2 1 0 0 1 1 1 1 Thaumatin family Nup88 PF10168.4 CCF35282.1 - 1.5 6.5 10.9 0.18 9.5 0.0 2.2 2 0 0 2 2 2 0 Nuclear pore component GAS PF13851.1 CCF35282.1 - 5 6.2 11.6 21 4.2 8.2 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF3826 PF12875.2 CCF35283.1 - 0.018 14.7 0.1 0.019 14.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3826) RRM_1 PF00076.17 CCF35283.1 - 0.025 14.2 0.0 0.046 13.3 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SUZ PF12752.2 CCF35283.1 - 0.073 13.6 1.3 0.29 11.6 0.0 2.1 2 0 0 2 2 2 0 SUZ domain DUF2665 PF11654.3 CCF35283.1 - 0.17 11.4 0.5 20 4.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2665) Oxysterol_BP PF01237.13 CCF35284.1 - 1.1e-46 158.9 0.0 5.9e-46 156.5 0.0 1.8 1 1 0 1 1 1 1 Oxysterol-binding protein Fungal_lectin PF07938.7 CCF35284.1 - 0.068 12.4 0.1 0.097 11.9 0.1 1.2 1 0 0 1 1 1 0 Fungal fucose-specific lectin Peptidase_S10 PF00450.17 CCF35285.1 - 4.6e-72 243.4 0.0 2.6e-71 240.9 0.0 2.1 1 1 0 1 1 1 1 Serine carboxypeptidase Pkinase PF00069.20 CCF35287.1 - 3.3e-14 52.6 0.0 1.6e-08 34.0 0.0 2.2 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CCF35287.1 - 0.0043 16.1 0.0 0.012 14.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase RTA1 PF04479.8 CCF35288.1 - 2.6e-54 184.1 6.4 4e-54 183.4 4.5 1.2 1 0 0 1 1 1 1 RTA1 like protein MARVEL PF01284.18 CCF35288.1 - 3.2 7.5 11.7 0.21 11.3 2.8 2.2 2 0 0 2 2 2 0 Membrane-associating domain Abhydrolase_5 PF12695.2 CCF35289.1 - 9.4e-13 48.1 0.3 4.7e-11 42.6 0.0 2.5 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF35289.1 - 5.9e-11 42.6 2.0 3.4e-10 40.2 0.1 2.2 1 1 1 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF35289.1 - 1.1e-05 24.7 0.0 2.1e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 CCF35289.1 - 0.00011 21.8 0.2 0.00019 21.0 0.2 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.15 CCF35289.1 - 0.013 14.9 0.6 0.06 12.7 0.0 2.2 3 0 0 3 3 3 0 Putative esterase Abhydrolase_3 PF07859.8 CCF35289.1 - 0.02 14.4 0.0 0.041 13.4 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold AXE1 PF05448.7 CCF35289.1 - 0.033 12.6 0.1 0.071 11.5 0.0 1.5 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) ADH_zinc_N PF00107.21 CCF35290.1 - 1.2e-09 37.7 0.0 2.2e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF35290.1 - 4.9e-08 32.6 0.1 2e-07 30.7 0.0 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain FAD_binding_4 PF01565.18 CCF35291.1 - 5.3e-29 100.4 5.1 1.5e-28 99.0 3.7 1.6 2 0 0 2 2 2 1 FAD binding domain Period_C PF12114.3 CCF35293.1 - 0.19 11.3 9.4 0.3 10.6 6.5 1.4 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Zip PF02535.17 CCF35293.1 - 0.49 9.3 4.9 0.55 9.1 3.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter PMI_typeI PF01238.16 CCF35294.1 - 2.8e-139 464.2 0.0 3.3e-139 464.0 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.6 CCF35294.1 - 0.059 12.8 0.0 1.4 8.5 0.0 2.4 2 0 0 2 2 2 0 Cupin domain AraC_binding PF02311.14 CCF35294.1 - 0.12 12.0 0.0 1.9 8.1 0.0 2.4 2 0 0 2 2 2 0 AraC-like ligand binding domain RraB PF06877.6 CCF35294.1 - 0.14 12.7 0.2 0.35 11.5 0.0 1.7 2 0 0 2 2 2 0 Regulator of ribonuclease activity B Crystall_2 PF09076.5 CCF35294.1 - 0.18 11.5 0.0 0.46 10.2 0.0 1.6 1 0 0 1 1 1 0 Beta/Gamma crystallin P2 PF07194.6 CCF35294.1 - 0.19 11.6 1.4 19 5.1 0.0 2.6 2 1 0 2 2 2 0 P2 response regulator binding domain DUF4110 PF13422.1 CCF35295.1 - 0.098 12.5 0.5 1.9 8.3 0.1 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4110) PapG_C PF03628.8 CCF35296.1 - 0.062 12.9 0.0 0.078 12.6 0.0 1.1 1 0 0 1 1 1 0 PapG chaperone-binding domain Zn_clus PF00172.13 CCF35298.1 - 3.9e-09 36.2 11.8 7.5e-09 35.3 8.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_17 PF00332.13 CCF35298.1 - 0.16 10.9 0.0 0.27 10.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 17 DUF3237 PF11578.3 CCF35300.1 - 1.2e-28 99.3 0.0 1.4e-28 99.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) Amidase PF01425.16 CCF35301.1 - 1.2e-79 268.2 0.0 1.5e-78 264.6 0.0 1.9 1 1 0 1 1 1 1 Amidase HTH_Tnp_Tc5 PF03221.11 CCF35302.1 - 2.2e-06 27.3 0.8 4.2e-06 26.4 0.0 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain zf-C2H2_4 PF13894.1 CCF35302.1 - 0.0064 16.7 23.8 0.24 11.8 2.9 5.0 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CCF35302.1 - 1.6 9.1 12.6 11 6.5 3.6 3.8 3 0 0 3 3 3 0 Zinc-finger double domain p450 PF00067.17 CCF35303.1 - 6.3e-52 176.6 0.0 7.8e-52 176.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 WD40 PF00400.27 CCF35304.1 - 5.3e-11 41.9 6.0 0.0017 18.1 0.0 6.5 7 0 0 7 7 7 3 WD domain, G-beta repeat LisH PF08513.6 CCF35304.1 - 9.2e-07 28.4 0.1 2.1e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 LisH IKI3 PF04762.7 CCF35304.1 - 0.022 12.6 0.0 0.11 10.2 0.0 1.9 2 0 0 2 2 2 0 IKI3 family Membr_traf_MHD PF10540.4 CCF35306.1 - 1.1e-22 80.2 1.6 2.5e-22 79.1 0.2 2.3 2 0 0 2 2 2 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.25 CCF35306.1 - 8.1e-18 64.0 0.3 5.1e-17 61.4 0.0 2.3 2 0 0 2 2 2 1 C2 domain RSN1_TM PF13967.1 CCF35308.1 - 3.3e-40 137.2 3.6 4.2e-40 136.8 2.5 1.1 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport DUF4463 PF14703.1 CCF35308.1 - 3.7e-19 69.0 1.2 5e-19 68.6 0.3 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4463) TMF_TATA_bd PF12325.3 CCF35308.1 - 0.08 12.6 0.0 3.8 7.2 0.0 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF1211 PF06736.6 CCF35308.1 - 0.37 10.9 7.2 1.3 9.2 0.5 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1211) Mito_carr PF00153.22 CCF35312.1 - 4.7e-17 61.4 4.2 0.00024 20.7 0.0 5.3 5 0 0 5 5 5 5 Mitochondrial carrier protein Fer2 PF00111.22 CCF35313.1 - 3.8e-13 48.9 1.1 5.5e-13 48.4 0.8 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Rrp15p PF07890.7 CCF35314.1 - 1.7e-35 121.9 13.7 1.7e-35 121.9 9.5 2.6 2 1 0 2 2 2 1 Rrp15p MR_MLE_N PF02746.11 CCF35314.1 - 0.039 13.9 0.2 0.1 12.5 0.1 1.7 1 0 0 1 1 1 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Acyltransferase PF01553.16 CCF35314.1 - 0.071 12.5 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Acyltransferase DUF2228 PF10228.4 CCF35314.1 - 0.2 11.1 2.0 0.35 10.3 1.4 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) SH3_1 PF00018.23 CCF35315.1 - 1.8e-05 24.0 0.0 4.5e-05 22.7 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 CCF35315.1 - 0.0073 15.8 0.0 0.018 14.5 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Bac_rhamnosid PF05592.6 CCF35316.1 - 0.0021 16.3 0.0 0.29 9.3 0.0 2.8 3 0 0 3 3 3 2 Bacterial alpha-L-rhamnosidase Glyco_hydro_20 PF00728.17 CCF35317.1 - 6.1e-35 121.0 0.5 5e-34 118.0 0.3 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.10 CCF35317.1 - 8.3e-07 29.5 0.0 1.7e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Conotoxin PF02950.12 CCF35318.1 - 0.081 13.7 0.6 0.091 13.5 0.4 1.1 1 0 0 1 1 1 0 Conotoxin TPPK_C PF12555.3 CCF35318.1 - 4 7.2 7.1 6 6.6 4.9 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal tRNA_bind PF01588.15 CCF35320.1 - 1.8e-23 82.1 0.4 1e-22 79.7 0.3 2.2 1 1 0 1 1 1 1 Putative tRNA binding domain GST_C_3 PF14497.1 CCF35320.1 - 1.6e-09 38.1 0.2 5.6e-09 36.3 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 CCF35320.1 - 2.7e-05 23.9 0.0 5e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 CCF35320.1 - 0.00045 20.1 0.5 0.0017 18.2 0.0 2.2 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain HSP9_HSP12 PF04119.7 CCF35320.1 - 0.1 12.6 3.0 0.21 11.7 1.7 1.8 1 1 0 1 1 1 0 Heat shock protein 9/12 SNF2_N PF00176.18 CCF35321.1 - 2.1e-67 227.0 0.0 4.4e-67 225.9 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CCF35321.1 - 4.1e-17 61.7 0.0 1.5e-16 60.0 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 CCF35321.1 - 1.6e-05 24.4 0.0 4.1e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Homez PF11569.3 CCF35321.1 - 0.042 12.9 0.1 0.1 11.6 0.1 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez SPT2 PF08243.6 CCF35321.1 - 1 9.6 19.0 4 7.7 3.2 2.8 2 0 0 2 2 2 0 SPT2 chromatin protein NTR2 PF15458.1 CCF35322.1 - 4.9e-80 268.4 17.9 4.9e-80 268.4 12.4 1.8 2 0 0 2 2 2 1 Nineteen complex-related protein 2 TMF_TATA_bd PF12325.3 CCF35322.1 - 0.026 14.2 4.6 0.086 12.5 0.5 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Macoilin PF09726.4 CCF35322.1 - 0.32 9.2 3.9 0.4 8.8 2.7 1.3 1 1 0 1 1 1 0 Transmembrane protein IncA PF04156.9 CCF35322.1 - 3.5 7.1 6.5 0.73 9.4 0.6 2.2 2 0 0 2 2 2 0 IncA protein DUF3844 PF12955.2 CCF35323.1 - 1.4e-32 111.8 1.8 2.5e-32 111.0 1.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) AAA_12 PF13087.1 CCF35325.1 - 3.6e-58 196.2 0.0 4.2e-58 196.0 0.0 1.0 1 0 0 1 1 1 1 AAA domain UvrD_C PF13361.1 CCF35325.1 - 0.00025 20.6 0.0 0.052 12.9 0.0 2.1 1 1 1 2 2 2 2 UvrD-like helicase C-terminal domain NAD_binding_8 PF13450.1 CCF35326.1 - 9.3e-13 48.0 0.0 2.2e-12 46.7 0.0 1.7 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 CCF35326.1 - 2.5e-11 43.3 0.0 4.9e-11 42.3 0.0 1.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.19 CCF35326.1 - 7.3e-09 34.9 0.1 1.4e-07 30.7 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 CCF35326.1 - 2.8e-05 24.4 0.2 0.001 19.4 0.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF35326.1 - 0.00016 21.4 0.0 0.0035 17.1 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 CCF35326.1 - 0.00018 21.4 0.2 0.036 13.9 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF35326.1 - 0.0037 15.9 0.1 0.0054 15.4 0.0 1.2 1 0 0 1 1 1 1 Tryptophan halogenase Thi4 PF01946.12 CCF35326.1 - 0.0053 15.8 0.0 0.0087 15.1 0.0 1.2 1 0 0 1 1 1 1 Thi4 family WND PF07861.6 CCF35326.1 - 0.043 12.8 0.1 0.069 12.1 0.0 1.2 1 0 0 1 1 1 0 WisP family N-Terminal Region Pyr_redox_3 PF13738.1 CCF35326.1 - 0.046 13.7 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.10 CCF35326.1 - 0.064 11.4 0.0 0.1 10.7 0.0 1.2 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) Strep_67kDa_ant PF06100.6 CCF35326.1 - 0.1 10.9 0.1 0.22 9.8 0.0 1.4 2 0 0 2 2 2 0 Streptococcal 67 kDa myosin-cross-reactive antigen like family FAD_binding_3 PF01494.14 CCF35326.1 - 0.17 10.9 0.1 0.36 9.8 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain zf-CCCH_2 PF14608.1 CCF35327.1 - 3.6e-10 39.4 59.6 2.4e-07 30.4 7.3 5.5 5 0 0 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type Nab2 PF11517.3 CCF35327.1 - 0.016 15.3 0.0 0.029 14.4 0.0 1.4 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) Glyco_hydro_20 PF00728.17 CCF35328.1 - 8e-84 281.7 0.0 1e-83 281.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.1 CCF35328.1 - 1.2e-23 84.1 0.0 2.6e-23 83.0 0.0 1.6 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.10 CCF35328.1 - 1.5e-06 28.7 0.0 5.1e-05 23.7 0.0 2.2 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 p450 PF00067.17 CCF35329.1 - 1.5e-60 205.0 0.0 2.2e-60 204.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Aminotran_1_2 PF00155.16 CCF35330.1 - 8.2e-21 74.3 0.0 1.1e-20 73.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.2 CCF35330.1 - 9.7e-06 24.3 0.0 2.4e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase DegT_DnrJ_EryC1 PF01041.12 CCF35330.1 - 0.0015 17.6 0.1 0.05 12.6 0.0 2.1 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family adh_short PF00106.20 CCF35331.1 - 4.8e-16 59.1 0.2 1.8e-15 57.2 0.1 1.8 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 CCF35331.1 - 2.5e-05 24.0 0.1 9.8e-05 22.0 0.1 1.8 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.1 CCF35331.1 - 3.8e-05 23.7 0.0 5.9e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF35331.1 - 0.00019 20.9 0.0 0.00024 20.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 CCF35331.1 - 0.0046 15.9 0.0 0.06 12.2 0.0 2.0 1 1 0 1 1 1 1 Male sterility protein adh_short_C2 PF13561.1 CCF35331.1 - 0.0063 16.3 0.0 0.015 15.0 0.0 1.6 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Glyco_transf_4 PF13439.1 CCF35331.1 - 0.011 15.4 0.1 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 YjeF_N PF03853.10 CCF35331.1 - 0.026 14.1 0.1 0.098 12.2 0.1 1.8 2 0 0 2 2 2 0 YjeF-related protein N-terminus NmrA PF05368.8 CCF35331.1 - 0.053 12.7 0.1 0.092 11.9 0.1 1.4 1 0 0 1 1 1 0 NmrA-like family Crystall_3 PF08964.5 CCF35332.1 - 0.06 13.0 0.0 0.19 11.4 0.0 1.8 1 1 1 2 2 2 0 Beta/Gamma crystallin MFS_1 PF07690.11 CCF35333.1 - 0.045 12.4 0.3 0.098 11.3 0.2 1.5 1 1 0 1 1 1 0 Major Facilitator Superfamily HECT PF00632.20 CCF35334.1 - 1.1e-97 327.0 0.1 2.7e-97 325.7 0.0 1.7 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) DUF4414 PF14377.1 CCF35334.1 - 5.1e-05 23.1 0.8 0.00027 20.8 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4414) SIMPL PF04402.9 CCF35334.1 - 0.011 15.6 6.1 0.021 14.6 4.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF541) Pribosyl_synth PF14572.1 CCF35335.1 - 5.7e-42 143.5 0.5 2.3e-36 125.2 0.3 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.1 CCF35335.1 - 3.2e-25 88.1 0.2 3.3e-24 84.8 0.0 2.4 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 CCF35335.1 - 1.1e-11 44.5 0.4 2.1e-11 43.5 0.3 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 CCF35335.1 - 0.0095 15.1 0.1 0.014 14.6 0.1 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Chlorosome_CsmC PF11098.3 CCF35335.1 - 0.1 12.3 1.2 0.19 11.4 0.8 1.4 1 0 0 1 1 1 0 Chlorosome envelope protein C tRNA-synt_2 PF00152.15 CCF35336.1 - 5.6e-71 239.0 0.2 9.1e-71 238.3 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 CCF35336.1 - 1.1e-10 41.1 0.1 2.8e-10 39.8 0.0 1.7 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain SPOUT_MTase PF02590.12 CCF35336.1 - 0.0098 15.6 0.8 0.019 14.6 0.5 1.4 1 0 0 1 1 1 1 Predicted SPOUT methyltransferase tRNA_anti_2 PF13742.1 CCF35336.1 - 0.068 13.0 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain PBP_sp32 PF07222.7 CCF35336.1 - 3 6.9 6.8 0.89 8.6 2.3 1.8 2 0 0 2 2 2 0 Proacrosin binding protein sp32 E1-E2_ATPase PF00122.15 CCF35338.1 - 3.4e-49 166.9 0.3 1.6e-48 164.7 0.1 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 CCF35338.1 - 1e-39 137.1 1.0 2.5e-39 135.9 0.7 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 CCF35338.1 - 9.8e-35 118.5 1.7 1.1e-11 44.6 0.0 5.0 5 0 0 5 5 5 4 Heavy-metal-associated domain HAD PF12710.2 CCF35338.1 - 1.1e-18 68.1 0.0 2.2e-18 67.0 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CCF35338.1 - 6.6e-07 29.1 0.2 3.2e-05 23.6 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Tox-PL-2 PF15643.1 CCF35338.1 - 0.00033 20.5 0.8 7.6 6.5 0.0 4.2 4 0 0 4 4 4 2 Papain fold toxin 2 7TM_GPCR_Srh PF10318.4 CCF35338.1 - 0.043 12.6 2.3 0.048 12.4 0.0 2.0 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srh Pox_E10 PF04805.7 CCF35338.1 - 3.7 7.1 7.2 2.1 7.9 0.0 3.6 5 0 0 5 5 5 0 E10-like protein conserved region Transketolase_C PF02780.15 CCF35339.1 - 0.00041 20.2 0.1 0.0013 18.6 0.1 1.8 1 0 0 1 1 1 1 Transketolase, C-terminal domain RskA PF10099.4 CCF35340.1 - 0.05 13.3 0.1 0.085 12.5 0.0 1.4 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Serglycin PF04360.7 CCF35340.1 - 1.3 8.7 3.6 2.2 8.0 2.5 1.3 1 0 0 1 1 1 0 Serglycin Abhydrolase_6 PF12697.2 CCF35342.1 - 2.1e-27 96.4 2.4 2.6e-27 96.2 1.7 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF35342.1 - 2e-10 40.6 1.0 7e-10 38.8 0.7 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF35342.1 - 2.9e-10 40.0 0.0 4.9e-10 39.3 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.7 CCF35342.1 - 0.015 13.7 0.0 0.022 13.2 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Hydrolase_4 PF12146.3 CCF35342.1 - 0.019 14.8 0.0 0.045 13.6 0.0 1.7 1 0 0 1 1 1 0 Putative lysophospholipase Pro_racemase PF05544.6 CCF35343.1 - 3.8e-57 193.5 0.0 5e-57 193.1 0.0 1.1 1 0 0 1 1 1 1 Proline racemase Calmodulin_bind PF07887.6 CCF35344.1 - 0.083 11.9 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Calmodulin binding protein-like Abhydrolase_1 PF00561.15 CCF35346.1 - 4.3e-43 147.5 0.0 5.6e-42 143.8 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF35346.1 - 1.8e-12 47.6 1.9 1.4e-11 44.7 1.3 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.5 CCF35346.1 - 0.097 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein DUF2424 PF10340.4 CCF35346.1 - 0.18 10.4 0.0 0.25 9.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2424) Sugar_tr PF00083.19 CCF35347.1 - 7.4e-43 146.7 6.4 8.3e-43 146.5 4.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.1 CCF35347.1 - 0.00012 20.6 8.0 0.00012 20.6 5.5 1.7 1 1 1 2 2 2 1 MFS/sugar transport protein DUF4448 PF14610.1 CCF35348.1 - 0.00074 19.0 0.2 0.0027 17.2 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF4448) DUF1183 PF06682.7 CCF35348.1 - 0.0017 18.0 0.2 0.0022 17.6 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1183) Herpes_gE PF02480.11 CCF35348.1 - 0.0018 16.5 0.0 0.0023 16.2 0.0 1.2 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E EphA2_TM PF14575.1 CCF35348.1 - 0.0024 18.2 0.4 0.0092 16.3 0.0 1.9 1 1 1 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.1 CCF35348.1 - 0.0025 18.0 5.1 0.0034 17.6 3.4 1.4 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator ETRAMP PF09716.5 CCF35348.1 - 0.0041 17.0 0.1 0.0068 16.3 0.1 1.3 1 0 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) Dehydrin PF00257.14 CCF35348.1 - 0.0055 17.0 9.1 0.0086 16.4 6.3 1.2 1 0 0 1 1 1 1 Dehydrin SR-25 PF10500.4 CCF35348.1 - 0.0061 16.0 3.8 0.0096 15.4 2.6 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Tetraspannin PF00335.15 CCF35348.1 - 0.016 14.5 0.4 0.024 13.8 0.3 1.2 1 0 0 1 1 1 0 Tetraspanin family TMEM154 PF15102.1 CCF35348.1 - 0.023 14.3 0.0 0.062 13.0 0.0 1.6 2 0 0 2 2 2 0 TMEM154 protein family 7tm_1 PF00001.16 CCF35348.1 - 0.023 13.8 0.0 0.029 13.5 0.0 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) CD34_antigen PF06365.7 CCF35348.1 - 0.04 13.5 0.1 0.085 12.4 0.0 1.6 2 0 0 2 2 2 0 CD34/Podocalyxin family Prominin PF05478.6 CCF35348.1 - 0.079 10.4 8.4 0.013 13.1 3.0 1.5 2 0 0 2 2 2 0 Prominin GRP PF07172.6 CCF35348.1 - 0.086 13.3 9.8 0.083 13.3 3.0 2.4 3 0 0 3 3 2 0 Glycine rich protein family IncA PF04156.9 CCF35348.1 - 0.14 11.7 0.6 0.24 10.9 0.4 1.4 1 1 0 1 1 1 0 IncA protein Tweety PF04906.8 CCF35348.1 - 0.15 10.4 2.9 0.37 9.1 0.9 1.9 2 0 0 2 2 2 0 Tweety SCIMP PF15050.1 CCF35348.1 - 0.16 11.8 0.4 0.16 11.8 0.3 1.6 2 0 0 2 2 2 0 SCIMP protein Adeno_E3_CR2 PF02439.10 CCF35348.1 - 0.82 9.2 13.0 1.5 8.4 9.0 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Corona_S2 PF01601.11 CCF35348.1 - 2 6.4 7.8 0.2 9.7 2.5 1.4 2 0 0 2 2 2 0 Coronavirus S2 glycoprotein Glypican PF01153.14 CCF35348.1 - 2.3 6.7 9.1 3.3 6.2 6.3 1.4 1 1 0 1 1 1 0 Glypican Yqai PF09466.5 CCF35349.1 - 0.048 13.6 0.0 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 Hypothetical protein Yqai zf-ZPR1 PF03367.8 CCF35349.1 - 0.11 11.6 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 ZPR1 zinc-finger domain p450 PF00067.17 CCF35350.1 - 9.9e-26 90.2 0.0 2.5e-22 79.0 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 DUF3095 PF11294.3 CCF35351.1 - 0.078 11.9 0.0 0.1 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3095) HET PF06985.6 CCF35352.1 - 9e-31 106.8 0.4 2.9e-30 105.2 0.3 1.8 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) AAL_decarboxy PF03306.8 CCF35352.1 - 0.049 12.6 0.1 0.09 11.8 0.0 1.3 1 0 0 1 1 1 0 Alpha-acetolactate decarboxylase Cpn60_TCP1 PF00118.19 CCF35353.1 - 1.5e-140 469.0 4.8 1.8e-140 468.8 3.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family zf-C2H2 PF00096.21 CCF35354.1 - 1.1e-10 41.2 18.1 0.00014 22.0 3.7 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CCF35354.1 - 9.4e-10 38.2 11.2 0.00015 21.8 0.1 3.7 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 CCF35354.1 - 0.00062 19.9 15.8 0.17 12.2 0.1 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-TRAF PF02176.13 CCF35354.1 - 0.21 11.9 6.4 0.48 10.8 4.5 1.6 1 0 0 1 1 1 0 TRAF-type zinc finger AT_hook PF02178.14 CCF35354.1 - 0.82 9.5 3.9 2.3 8.1 2.7 1.8 1 0 0 1 1 1 0 AT hook motif zf-C2H2_6 PF13912.1 CCF35354.1 - 9 6.3 10.6 0.59 10.1 0.2 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger MFS_1 PF07690.11 CCF35355.1 - 1.9e-20 72.9 38.7 1.9e-20 72.9 26.8 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF872 PF05915.7 CCF35355.1 - 0.48 10.2 3.5 9.7 6.0 0.4 2.6 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) SpoVAB PF13782.1 CCF35355.1 - 3.1 7.7 10.0 0.19 11.7 1.7 2.9 2 2 0 2 2 2 0 Stage V sporulation protein AB GMC_oxred_N PF00732.14 CCF35356.1 - 1.4e-55 188.5 0.0 1.9e-55 188.1 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF35356.1 - 2.7e-36 125.0 0.0 4e-36 124.4 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 CCF35356.1 - 6e-08 31.9 0.2 0.0084 15.0 0.0 2.4 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 CCF35356.1 - 0.00019 20.4 0.1 0.0016 17.4 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 CCF35356.1 - 0.00041 19.3 0.2 0.0006 18.8 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 CCF35356.1 - 0.0039 17.1 0.3 0.0097 15.9 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 CCF35356.1 - 0.012 14.6 0.0 0.02 13.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.9 CCF35356.1 - 0.017 15.0 0.0 0.04 13.7 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CCF35356.1 - 0.23 10.2 0.3 0.61 8.8 0.1 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A HTH_psq PF05225.11 CCF35357.1 - 1.4e-14 53.3 0.2 2.4e-14 52.5 0.2 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF35357.1 - 1.5e-12 47.0 0.4 5.8e-12 45.2 0.0 2.1 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.1 CCF35357.1 - 7e-05 22.3 0.1 0.00026 20.5 0.0 1.9 1 1 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 CCF35357.1 - 0.00031 20.6 0.1 0.00087 19.2 0.1 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_7 PF02796.10 CCF35357.1 - 0.00071 19.3 0.1 0.0013 18.5 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.1 CCF35357.1 - 0.0024 17.4 0.1 0.0051 16.3 0.1 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_1 PF00126.22 CCF35357.1 - 0.024 14.3 0.3 0.052 13.2 0.2 1.6 1 1 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family SpoIIID PF12116.3 CCF35357.1 - 0.053 13.4 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Stage III sporulation protein D CENP-B_N PF04218.8 CCF35357.1 - 0.062 12.7 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_8 PF02954.14 CCF35357.1 - 0.098 12.2 0.7 0.59 9.7 0.0 2.3 1 1 1 2 2 2 0 Bacterial regulatory protein, Fis family HTH_Tnp_1 PF01527.15 CCF35357.1 - 0.14 12.0 1.3 0.46 10.4 0.0 2.2 2 1 0 3 3 3 0 Transposase Fungal_trans_2 PF11951.3 CCF35358.1 - 4.5e-07 28.8 0.0 7e-07 28.1 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF35358.1 - 1.3e-06 28.2 9.3 2e-06 27.5 6.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glycoprotein_B PF00606.13 CCF35359.1 - 0.59 8.1 2.7 0.58 8.1 1.9 1.0 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B zf-3CxxC PF13695.1 CCF35360.1 - 9.7e-28 96.2 0.2 1.7e-27 95.5 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding domain Fungal_trans PF04082.13 CCF35361.1 - 5.1e-13 48.4 0.0 1.2e-12 47.2 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF35361.1 - 0.00094 19.0 6.3 0.0015 18.4 4.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain dCMP_cyt_deam_1 PF00383.17 CCF35363.1 - 1.9e-08 33.8 0.0 2.9e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Methyltransf_16 PF10294.4 CCF35364.1 - 7.8e-24 84.0 0.0 7.2e-23 80.9 0.0 2.1 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 CCF35364.1 - 0.00069 19.3 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF35364.1 - 0.0052 17.2 0.0 0.0092 16.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF35364.1 - 0.0091 16.0 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain RRM_1 PF00076.17 CCF35369.1 - 2.6e-20 71.8 0.0 3.3e-20 71.5 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF35369.1 - 4e-12 45.9 0.0 5e-12 45.6 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF35369.1 - 0.00074 19.3 0.1 0.00098 18.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF35370.1 - 1.1e-39 134.2 0.0 6.2e-10 38.9 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CCF35370.1 - 8.3e-37 124.6 0.1 3.5e-11 42.5 0.1 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF35370.1 - 5.1e-20 71.0 0.8 0.00013 21.7 0.0 5.1 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM PF10378.4 CCF35370.1 - 1.1e-13 50.5 6.3 1.1e-13 50.5 4.4 3.7 4 1 1 5 5 5 1 Putative RRM domain RRM_3 PF08777.6 CCF35370.1 - 0.0015 18.3 5.8 0.0082 15.9 0.1 2.7 3 0 0 3 3 3 1 RNA binding motif RNA_bind PF08675.6 CCF35370.1 - 0.065 13.2 0.1 0.33 10.9 0.0 2.2 2 0 0 2 2 2 0 RNA binding domain DUF4523 PF15023.1 CCF35370.1 - 0.071 12.6 0.0 2.7 7.4 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4523) Neurochondrin PF05536.6 CCF35371.1 - 2.7e-29 101.9 0.0 3.1e-29 101.7 0.0 1.0 1 0 0 1 1 1 1 Neurochondrin Pro-kuma_activ PF09286.6 CCF35372.1 - 0.041 13.9 0.6 0.2 11.7 0.1 2.2 2 1 0 2 2 2 0 Pro-kumamolisin, activation domain Utp13 PF08625.6 CCF35372.1 - 0.055 13.1 0.4 2.8 7.5 0.3 2.3 1 1 0 1 1 1 0 Utp13 specific WD40 associated domain ENT PF03735.9 CCF35372.1 - 0.086 12.5 0.4 4.7 7.0 0.1 3.0 2 1 0 2 2 2 0 ENT domain AAA PF00004.24 CCF35373.1 - 4.7e-18 65.6 0.1 5.8e-16 58.8 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF35373.1 - 0.005 16.8 0.0 0.022 14.7 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CCF35373.1 - 0.006 16.7 3.0 0.012 15.7 0.1 3.0 3 1 0 3 3 3 1 AAA domain AAA_11 PF13086.1 CCF35373.1 - 0.0075 15.8 0.7 0.55 9.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CCF35373.1 - 0.0096 15.6 0.1 0.025 14.2 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 CCF35373.1 - 0.015 15.0 0.0 0.039 13.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Zot PF05707.7 CCF35373.1 - 0.015 14.7 0.3 0.62 9.4 0.2 2.4 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_17 PF13207.1 CCF35373.1 - 0.035 14.9 0.0 0.15 12.9 0.0 2.2 1 0 0 1 1 1 0 AAA domain Torsin PF06309.6 CCF35373.1 - 0.036 13.9 0.0 0.12 12.2 0.0 1.9 1 0 0 1 1 1 0 Torsin AAA_33 PF13671.1 CCF35373.1 - 0.039 13.8 0.0 0.21 11.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain DDE_1 PF03184.14 CCF35374.1 - 9.8e-05 21.5 0.0 0.00016 20.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease MFS_1 PF07690.11 CCF35376.1 - 4.2e-25 88.2 26.3 6e-25 87.6 18.1 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Uso1_p115_head PF04869.9 CCF35377.1 - 2.5e-109 364.8 0.0 6.7e-109 363.4 0.0 1.8 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.8 CCF35377.1 - 4.6e-09 36.3 30.6 4.6e-09 36.3 21.2 3.8 1 1 2 3 3 3 1 Uso1 / p115 like vesicle tethering protein, C terminal region DUF3584 PF12128.3 CCF35377.1 - 0.038 11.3 67.7 0.068 10.4 46.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Methyltransf_31 PF13847.1 CCF35378.1 - 4.6e-11 42.5 0.0 9.9e-11 41.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 CCF35378.1 - 4.9e-11 42.3 0.0 1.3e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.7 CCF35378.1 - 5.1e-11 42.9 0.0 1.4e-10 41.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF35378.1 - 1.2e-09 38.6 0.1 3.4e-09 37.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF35378.1 - 1.1e-07 31.8 0.0 2.4e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF35378.1 - 1.9e-06 28.1 0.0 4.2e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF35378.1 - 2e-06 27.3 0.1 4.3e-06 26.2 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.1 CCF35378.1 - 6.3e-06 26.0 0.0 1.2e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF35378.1 - 1.6e-05 25.2 0.0 4.4e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 CCF35378.1 - 0.00013 21.4 0.0 0.0019 17.6 0.0 2.6 3 0 0 3 3 3 1 Putative methyltransferase Methyltransf_9 PF08003.6 CCF35378.1 - 0.0033 16.1 0.1 0.0055 15.4 0.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) PRMT5 PF05185.11 CCF35378.1 - 0.0035 16.3 0.1 0.011 14.6 0.0 1.8 1 1 0 1 1 1 1 PRMT5 arginine-N-methyltransferase UPF0020 PF01170.13 CCF35378.1 - 0.018 14.6 0.1 0.036 13.6 0.1 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 CMAS PF02353.15 CCF35378.1 - 0.023 13.7 0.0 0.052 12.6 0.0 1.5 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase TehB PF03848.9 CCF35378.1 - 0.024 13.7 0.0 0.044 12.9 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB FtsJ PF01728.14 CCF35378.1 - 0.055 13.4 0.0 0.092 12.7 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.14 CCF35378.1 - 0.084 12.3 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) OPT PF03169.10 CCF35379.1 - 5.8e-154 513.9 26.3 6.8e-154 513.6 18.2 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Rav1p_C PF12234.3 CCF35380.1 - 6.1e-262 870.3 0.0 8.1e-262 869.9 0.0 1.1 1 0 0 1 1 1 1 RAVE protein 1 C terminal WD40 PF00400.27 CCF35380.1 - 0.00096 18.9 1.6 2.1 8.3 0.0 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat HTH_Tnp_Tc5 PF03221.11 CCF35382.1 - 1.8e-09 37.2 0.1 5.4e-09 35.7 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 CCF35382.1 - 0.00024 20.4 0.0 0.00041 19.7 0.0 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain MarR PF01047.17 CCF35382.1 - 0.0073 15.9 0.0 0.023 14.3 0.0 1.8 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.1 CCF35382.1 - 0.017 14.9 0.0 0.052 13.3 0.0 1.7 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_Tnp_4 PF13613.1 CCF35382.1 - 0.019 14.4 0.0 0.039 13.4 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease HTH_23 PF13384.1 CCF35382.1 - 0.09 12.4 0.0 0.25 11.0 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain PTR2 PF00854.16 CCF35383.1 - 7e-41 140.2 15.9 3e-20 72.3 5.9 2.5 2 1 0 2 2 2 2 POT family MFS_1 PF07690.11 CCF35383.1 - 0.00036 19.3 31.3 0.00036 19.3 21.7 2.7 1 1 0 2 2 2 1 Major Facilitator Superfamily KAT11 PF08214.6 CCF35384.1 - 3.2e-95 319.1 0.0 4.5e-95 318.6 0.0 1.2 1 0 0 1 1 1 1 Histone acetylation protein Herpes_DNAp_acc PF04929.7 CCF35384.1 - 2.4 7.0 7.2 1.7 7.5 3.8 1.5 2 0 0 2 2 2 0 Herpes DNA replication accessory factor GDI PF00996.13 CCF35386.1 - 1.7e-185 616.4 0.0 2e-185 616.2 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.1 CCF35386.1 - 0.062 13.3 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NOGCT PF08155.6 CCF35387.1 - 3.3e-28 97.1 0.7 7e-28 96.0 0.5 1.6 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.9 CCF35387.1 - 9.9e-27 92.6 2.8 1.1e-26 92.4 0.9 1.9 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.18 CCF35387.1 - 1.4e-13 50.8 0.0 2.9e-13 49.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CCF35387.1 - 2.2e-08 33.5 0.0 4.1e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.7 CCF35387.1 - 0.00074 18.7 0.1 0.0013 17.9 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 CCF35387.1 - 0.014 14.7 0.4 0.068 12.5 0.2 2.1 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain APH PF01636.18 CCF35387.1 - 0.02 14.6 0.0 0.051 13.2 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Miro PF08477.8 CCF35387.1 - 0.023 15.1 0.0 0.076 13.5 0.0 2.0 2 0 0 2 2 2 0 Miro-like protein Dynamin_N PF00350.18 CCF35387.1 - 0.16 11.7 3.5 2.2 8.0 0.0 2.8 3 0 0 3 3 3 0 Dynamin family CD99L2 PF12301.3 CCF35387.1 - 0.34 10.5 3.7 0.61 9.7 2.5 1.5 1 0 0 1 1 1 0 CD99 antigen like protein 2 Aconitase PF00330.15 CCF35388.1 - 6.6e-67 225.9 0.0 1.5e-40 139.0 0.0 2.2 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 CCF35388.1 - 2.3e-24 85.9 0.0 4.4e-24 85.0 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain zf-C4 PF00105.13 CCF35390.1 - 8 6.7 8.1 32 4.8 0.1 3.0 2 1 1 3 3 3 0 Zinc finger, C4 type (two domains) adh_short PF00106.20 CCF35391.1 - 3.6e-05 23.7 0.0 5.9e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF35391.1 - 0.022 14.4 0.0 0.043 13.4 0.0 1.4 1 0 0 1 1 1 0 KR domain NmrA PF05368.8 CCF35392.1 - 3.1e-35 121.5 0.0 4.5e-35 120.9 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF35392.1 - 8.2e-13 48.7 0.1 1e-12 48.4 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 CCF35392.1 - 5.6e-08 32.8 1.2 1e-07 32.0 0.8 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF35392.1 - 2.5e-07 30.5 0.5 3.8e-07 29.9 0.4 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF35392.1 - 6.1e-05 22.5 0.0 0.00013 21.5 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF35392.1 - 9.8e-05 21.1 0.0 0.00014 20.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 CCF35392.1 - 0.029 13.3 0.0 0.49 9.2 0.0 2.2 2 0 0 2 2 2 0 Male sterility protein DapB_N PF01113.15 CCF35392.1 - 0.073 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus CDP-OH_P_transf PF01066.16 CCF35394.1 - 7.2e-19 67.9 4.1 7.2e-19 67.9 2.8 1.8 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase MFS_1 PF07690.11 CCF35395.1 - 1.3e-28 99.7 26.5 1.3e-28 99.7 18.4 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Phage_holin_5 PF06946.6 CCF35395.1 - 0.43 10.7 3.4 20 5.4 0.1 2.5 2 0 0 2 2 2 0 Phage holin DUF4231 PF14015.1 CCF35395.1 - 0.44 10.5 2.4 21 5.1 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) DUF4233 PF14017.1 CCF35395.1 - 0.88 9.5 6.4 0.27 11.1 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4233) Sin_N PF04801.8 CCF35397.1 - 4e-07 29.2 0.1 5.1e-07 28.8 0.1 1.3 1 1 0 1 1 1 1 Sin-like protein conserved region Snf7 PF03357.16 CCF35398.1 - 1.2e-29 102.9 16.9 1.3e-29 102.7 11.7 1.0 1 0 0 1 1 1 1 Snf7 Upf2 PF04050.9 CCF35398.1 - 0.0081 15.9 3.9 0.0081 15.9 2.7 1.8 1 1 1 2 2 2 1 Up-frameshift suppressor 2 DUF885 PF05960.6 CCF35398.1 - 0.37 9.8 4.5 0.43 9.6 3.1 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Allexi_40kDa PF05549.6 CCF35398.1 - 0.93 8.7 6.5 1.4 8.1 4.5 1.4 1 1 0 1 1 1 0 Allexivirus 40kDa protein BLOC1_2 PF10046.4 CCF35398.1 - 1.6 8.9 13.2 1.2 9.3 0.6 3.3 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3508 PF12018.3 CCF35398.1 - 3.1 6.7 8.3 2.7 6.9 1.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3508) DUF3138 PF11336.3 CCF35398.1 - 3.9 5.5 5.4 2 6.5 1.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) Ten1 PF12658.2 CCF35399.1 - 5.2e-32 110.2 0.0 5.9e-32 110.0 0.0 1.0 1 0 0 1 1 1 1 Telomere capping, CST complex subunit Ten1_2 PF15490.1 CCF35399.1 - 6.1e-05 22.5 0.0 7.5e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit Rep_fac-A_3 PF08661.6 CCF35399.1 - 0.085 12.7 0.0 0.13 12.1 0.0 1.3 1 1 0 1 1 1 0 Replication factor A protein 3 Alpha_L_fucos PF01120.12 CCF35401.1 - 0.13 11.1 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 Alpha-L-fucosidase Acetate_kinase PF00871.12 CCF35402.1 - 3.6e-96 322.0 0.0 4.4e-96 321.7 0.0 1.0 1 0 0 1 1 1 1 Acetokinase family Inositol_P PF00459.20 CCF35403.1 - 5.8e-51 173.3 1.1 9.6e-51 172.6 0.8 1.3 1 1 0 1 1 1 1 Inositol monophosphatase family DUF2630 PF10944.3 CCF35403.1 - 0.013 15.5 0.1 0.026 14.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2630) Ribosomal_L6 PF00347.18 CCF35404.1 - 2.5e-20 72.7 0.0 1e-10 41.9 0.0 3.2 3 1 0 3 3 3 2 Ribosomal protein L6 Tubulin PF00091.20 CCF35405.1 - 1.7e-70 237.2 0.0 2.9e-70 236.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 CCF35405.1 - 8.7e-49 164.7 0.1 1.5e-48 164.0 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 CCF35405.1 - 5.4e-06 26.4 0.0 1.8e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.1 CCF35405.1 - 0.0052 16.2 0.0 0.0092 15.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain ABC_tran PF00005.22 CCF35406.1 - 2.3e-49 167.2 0.5 3.7e-23 82.3 0.0 3.3 3 0 0 3 3 3 2 ABC transporter ABC_tran_2 PF12848.2 CCF35406.1 - 1.5e-20 72.7 7.1 1.5e-20 72.7 4.9 4.0 5 0 0 5 5 4 1 ABC transporter AAA_21 PF13304.1 CCF35406.1 - 1.9e-17 64.2 0.0 0.00013 22.0 0.0 4.5 3 1 1 4 4 4 3 AAA domain SMC_N PF02463.14 CCF35406.1 - 4.5e-11 42.4 0.9 0.0017 17.5 0.0 4.5 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 CCF35406.1 - 4.7e-09 37.1 2.1 0.0024 18.6 0.0 3.3 3 1 0 3 3 2 2 AAA domain AAA_29 PF13555.1 CCF35406.1 - 1.5e-06 27.6 0.3 0.016 14.7 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_18 PF13238.1 CCF35406.1 - 4.1e-06 27.1 2.2 0.059 13.6 0.0 3.6 5 0 0 5 5 2 2 AAA domain MMR_HSR1 PF01926.18 CCF35406.1 - 5.2e-06 26.3 0.0 0.02 14.8 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase DUF258 PF03193.11 CCF35406.1 - 8.1e-06 25.1 0.0 0.025 13.7 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Miro PF08477.8 CCF35406.1 - 1.7e-05 25.3 0.0 0.095 13.2 0.0 3.0 2 0 0 2 2 2 2 Miro-like protein AAA_33 PF13671.1 CCF35406.1 - 2e-05 24.5 0.0 0.14 12.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.1 CCF35406.1 - 2.7e-05 23.4 5.2 0.48 9.3 0.0 4.4 4 2 1 5 5 5 2 AAA ATPase domain MobB PF03205.9 CCF35406.1 - 3e-05 23.7 0.2 0.15 11.7 0.1 2.6 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 CCF35406.1 - 4.8e-05 23.4 0.6 0.03 14.2 0.1 2.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.1 CCF35406.1 - 6.1e-05 23.4 14.6 0.037 14.3 0.0 4.7 5 0 0 5 5 5 2 AAA domain AAA_22 PF13401.1 CCF35406.1 - 6.6e-05 23.0 0.2 1.2 9.3 0.1 3.5 3 1 0 3 3 2 2 AAA domain AAA_28 PF13521.1 CCF35406.1 - 8e-05 22.6 1.2 0.055 13.4 0.0 2.9 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.1 CCF35406.1 - 0.00045 20.0 0.8 2 8.4 0.2 4.0 3 1 0 3 3 2 1 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.1 CCF35406.1 - 0.00054 19.8 0.1 2.4 8.0 0.0 3.2 3 0 0 3 3 2 2 AAA domain AAA PF00004.24 CCF35406.1 - 0.00057 20.0 0.0 0.47 10.6 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ArgK PF03308.11 CCF35406.1 - 0.00061 18.6 0.1 1.2 7.8 0.0 2.8 2 0 0 2 2 2 2 ArgK protein Dynamin_N PF00350.18 CCF35406.1 - 0.0008 19.2 6.8 0.36 10.6 0.0 4.1 4 1 0 4 4 4 2 Dynamin family AAA_10 PF12846.2 CCF35406.1 - 0.0015 18.0 0.0 3.6 6.9 0.1 3.8 4 0 0 4 4 4 1 AAA-like domain NACHT PF05729.7 CCF35406.1 - 0.002 17.8 0.1 3 7.4 0.0 2.7 2 0 0 2 2 2 2 NACHT domain RNA_helicase PF00910.17 CCF35406.1 - 0.0041 17.2 0.0 2.6 8.2 0.0 2.7 2 0 0 2 2 2 1 RNA helicase NTPase_1 PF03266.10 CCF35406.1 - 0.0069 16.1 0.1 1.2 8.8 0.0 2.7 2 0 0 2 2 2 1 NTPase cobW PF02492.14 CCF35406.1 - 0.0087 15.5 0.4 2.2 7.6 0.5 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.1 CCF35406.1 - 0.011 15.0 0.0 5.4 6.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 CCF35406.1 - 0.016 14.9 0.2 5.3 6.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) GTP_EFTU PF00009.22 CCF35406.1 - 0.035 13.5 0.6 11 5.3 0.0 3.0 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain ATP-synt_ab PF00006.20 CCF35406.1 - 0.036 13.5 0.0 2.9 7.3 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_19 PF13245.1 CCF35406.1 - 0.048 13.4 0.1 5.2 6.8 0.1 3.3 3 0 0 3 3 3 0 Part of AAA domain NB-ARC PF00931.17 CCF35406.1 - 0.055 12.3 0.0 11 4.7 0.0 2.6 2 0 0 2 2 2 0 NB-ARC domain PduV-EutP PF10662.4 CCF35406.1 - 0.096 12.1 0.1 13 5.2 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF87 PF01935.12 CCF35406.1 - 0.79 9.4 8.6 1.4 8.6 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function DUF87 SRP54 PF00448.17 CCF35406.1 - 2.7 7.3 7.5 4 6.8 0.1 3.5 4 0 0 4 4 4 0 SRP54-type protein, GTPase domain ADH_N PF08240.7 CCF35412.1 - 1.3e-28 98.8 0.2 2.4e-28 98.0 0.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF35412.1 - 1.2e-27 96.0 0.1 2.1e-27 95.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF35412.1 - 0.00039 21.3 0.0 0.00071 20.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Actin PF00022.14 CCF35413.1 - 7.2e-90 301.2 0.0 1.6e-89 300.1 0.0 1.5 1 1 0 1 1 1 1 Actin NmrA PF05368.8 CCF35414.1 - 3.2e-21 75.6 0.0 4e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF35414.1 - 0.0048 16.9 0.0 0.022 14.7 0.0 1.9 2 0 0 2 2 2 1 NADH(P)-binding Epimerase PF01370.16 CCF35414.1 - 0.024 14.0 0.2 0.055 12.8 0.0 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family adh_short PF00106.20 CCF35414.1 - 0.025 14.5 0.1 0.041 13.8 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase KR PF08659.5 CCF35414.1 - 0.053 13.1 0.0 0.086 12.5 0.0 1.3 1 0 0 1 1 1 0 KR domain adh_short PF00106.20 CCF35415.1 - 4.1e-14 52.8 0.0 6.7e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF35415.1 - 8.3e-07 28.8 0.0 1.3e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.7 CCF35415.1 - 1.8e-05 23.8 0.0 2.4e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 CCF35415.1 - 0.00024 21.1 0.0 0.00057 19.9 0.0 1.8 1 1 0 1 1 1 1 NADH(P)-binding adh_short_C2 PF13561.1 CCF35415.1 - 0.0062 16.3 0.0 0.016 15.0 0.0 1.6 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.10 CCF35415.1 - 0.018 13.9 0.0 0.027 13.3 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Shikimate_DH PF01488.15 CCF35415.1 - 0.018 15.1 0.0 0.026 14.5 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.16 CCF35415.1 - 0.032 13.6 0.0 0.072 12.5 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DFP PF04127.10 CCF35415.1 - 0.15 11.7 0.1 0.35 10.4 0.0 1.6 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein THF_DHG_CYH_C PF02882.14 CCF35415.1 - 0.15 11.1 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Mito_carr PF00153.22 CCF35416.1 - 5.7e-51 170.1 5.7 7.5e-25 86.4 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4098 PF13345.1 CCF35417.1 - 5e-06 26.3 14.3 0.011 15.6 0.1 5.9 5 2 0 5 5 5 3 Domain of unknown function (DUF4098) DUF2154 PF09922.4 CCF35417.1 - 0.21 11.2 0.2 11 5.7 0.0 3.0 4 0 0 4 4 4 0 Cell wall-active antibiotics response protein (DUF2154) Pkinase PF00069.20 CCF35418.1 - 2e-64 217.2 0.0 3.2e-64 216.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF35418.1 - 4.8e-28 97.9 0.0 8.7e-28 97.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 CCF35418.1 - 3.8e-10 39.7 0.1 9.9e-09 35.2 0.0 2.9 3 0 0 3 3 3 1 FHA domain Kinase-like PF14531.1 CCF35418.1 - 7.5e-05 21.8 0.0 0.00023 20.2 0.0 1.7 1 1 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 CCF35418.1 - 0.12 11.7 0.0 0.37 10.1 0.0 1.8 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL CRT10 PF08728.5 CCF35419.1 - 3.5e-13 48.4 0.0 5e-13 47.9 0.0 1.1 1 0 0 1 1 1 1 CRT10 Cellulase PF00150.13 CCF35420.1 - 1.8e-37 129.1 0.2 2.1e-37 128.8 0.1 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Zn_clus PF00172.13 CCF35421.1 - 7.6e-09 35.3 13.1 1.4e-08 34.5 9.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BpuJI_N PF11564.3 CCF35421.1 - 0.2 10.5 0.0 0.34 9.8 0.0 1.3 1 0 0 1 1 1 0 Restriction endonuclease BpuJI - N terminal Glyco_hydro_76 PF03663.9 CCF35422.1 - 0.12 11.7 0.3 0.13 11.6 0.2 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 76 RGS PF00615.14 CCF35423.1 - 0.00026 21.0 0.1 0.045 13.8 0.0 2.4 2 0 0 2 2 2 2 Regulator of G protein signaling domain Pox_A14 PF05767.7 CCF35423.1 - 0.038 13.9 0.1 0.097 12.6 0.1 1.6 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 DUF718 PF05336.8 CCF35423.1 - 0.062 13.1 0.8 0.16 11.7 0.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF718) 2TM PF13239.1 CCF35423.1 - 0.44 10.6 2.1 0.96 9.5 1.5 1.6 1 0 0 1 1 1 0 2TM domain Glyco_transf_22 PF03901.12 CCF35424.1 - 8.9e-42 143.5 16.5 1.1e-41 143.2 11.5 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Yos1 PF08571.5 CCF35425.1 - 2.9e-29 100.9 1.5 3.3e-29 100.8 1.1 1.0 1 0 0 1 1 1 1 Yos1-like UCH PF00443.24 CCF35426.1 - 7.1e-62 208.9 1.5 8.1e-62 208.7 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CCF35426.1 - 3.2e-29 102.3 5.9 4.1e-23 82.2 0.0 2.7 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Spore_coat_CotO PF14153.1 CCF35426.1 - 2.1 7.7 20.1 4.8 6.5 13.9 1.6 1 0 0 1 1 1 0 Spore coat protein CotO LSM PF01423.17 CCF35428.1 - 4e-18 64.7 0.2 5.1e-18 64.3 0.1 1.1 1 0 0 1 1 1 1 LSM domain VPS9 PF02204.13 CCF35430.1 - 3.4e-17 62.3 0.2 7.8e-17 61.2 0.1 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.1 CCF35430.1 - 1.3e-13 50.6 0.6 3.3e-08 33.5 0.0 5.5 5 1 1 6 6 6 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 CCF35430.1 - 1.1e-12 48.1 0.0 2.9e-05 24.3 0.0 3.8 3 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF35430.1 - 1.2e-12 48.0 0.4 0.0063 17.0 0.0 5.6 4 1 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF35430.1 - 8.3e-09 34.8 2.5 0.28 11.5 0.0 6.4 6 1 0 6 6 6 2 Ankyrin repeat Ank PF00023.25 CCF35430.1 - 6.1e-07 28.9 2.4 0.0045 16.7 0.0 5.0 5 1 0 5 5 5 2 Ankyrin repeat PX PF00787.19 CCF35430.1 - 0.028 14.2 0.4 0.097 12.4 0.0 2.2 3 0 0 3 3 3 0 PX domain NAD_binding_1 PF00175.16 CCF35431.1 - 1.3e-24 86.9 0.0 2.4e-24 86.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 CCF35431.1 - 5.3e-14 52.1 0.0 9.9e-14 51.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 CCF35431.1 - 2e-06 27.8 0.2 0.0065 16.3 0.0 2.5 3 0 0 3 3 3 2 Ferric reductase NAD binding domain APH PF01636.18 CCF35433.1 - 1.9e-07 31.0 1.4 1.5e-06 28.1 1.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CCF35433.1 - 0.0015 18.1 0.1 0.06 12.9 0.0 2.4 2 0 0 2 2 2 1 Choline/ethanolamine kinase 2OG-FeII_Oxy PF03171.15 CCF35434.1 - 3.4e-05 24.0 0.1 6.3e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 CCF35434.1 - 0.00049 20.5 0.1 0.0012 19.3 0.1 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TBP PF00352.16 CCF35436.1 - 2.9e-69 228.4 0.1 3.6e-34 115.9 0.0 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 CCF35436.1 - 8.1e-05 22.6 0.2 1.1 9.3 0.0 3.2 2 1 1 3 3 3 2 Domain of unknown function (DUF3378) Pollen_allerg_2 PF01620.11 CCF35436.1 - 0.006 16.9 0.7 0.0094 16.2 0.5 1.3 1 0 0 1 1 1 1 Ribonuclease (pollen allergen) DAO PF01266.19 CCF35437.1 - 7.4e-47 159.9 0.1 2.5e-46 158.2 0.1 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 CCF35437.1 - 1.2e-06 28.4 0.1 0.019 14.7 0.0 2.6 2 0 0 2 2 2 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 CCF35437.1 - 4.4e-06 26.6 0.0 1e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF35437.1 - 0.00094 19.1 0.0 0.4 10.5 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF35437.1 - 0.006 15.4 0.0 0.69 8.6 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain GIDA PF01134.17 CCF35437.1 - 0.0092 14.8 0.0 0.034 13.0 0.0 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A Ribosomal_S25 PF03297.10 CCF35437.1 - 0.012 15.6 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 S25 ribosomal protein Trp_halogenase PF04820.9 CCF35437.1 - 0.023 13.3 0.0 0.9 8.0 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox_3 PF13738.1 CCF35437.1 - 0.023 14.7 0.0 0.67 9.9 0.0 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF35437.1 - 0.042 12.7 0.0 0.083 11.7 0.0 1.4 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Bac_luciferase PF00296.15 CCF35439.1 - 5.6e-62 209.6 2.3 7.8e-62 209.1 1.6 1.2 1 0 0 1 1 1 1 Luciferase-like monooxygenase AcetylCoA_hydro PF02550.10 CCF35440.1 - 2.3e-45 154.7 0.0 3.8e-45 154.0 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.1 CCF35440.1 - 1.1e-40 138.8 0.0 1.7e-40 138.2 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain PH PF00169.24 CCF35441.1 - 2.1e-05 24.6 0.0 0.00025 21.1 0.0 2.4 2 0 0 2 2 2 1 PH domain PH_9 PF15410.1 CCF35441.1 - 0.004 17.3 0.0 0.004 17.3 0.0 2.7 3 0 0 3 3 3 1 Pleckstrin homology domain AMP-binding PF00501.23 CCF35442.1 - 4.6e-61 206.4 0.0 5.8e-61 206.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.20 CCF35442.1 - 1.5e-05 25.1 0.1 3.9e-05 23.8 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site RRM_1 PF00076.17 CCF35443.1 - 4.7e-17 61.3 0.0 7.5e-17 60.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF35443.1 - 3.1e-15 55.9 0.0 5.3e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF35443.1 - 7.4e-05 22.5 0.0 0.00013 21.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) V_ATPase_I PF01496.14 CCF35443.1 - 0.0032 15.3 1.1 0.0038 15.1 0.7 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family IncA PF04156.9 CCF35443.1 - 0.094 12.3 4.4 0.13 11.8 3.0 1.1 1 0 0 1 1 1 0 IncA protein APG6 PF04111.7 CCF35443.1 - 0.11 11.4 3.0 0.13 11.2 2.1 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 PA26 PF04636.8 CCF35443.1 - 0.34 9.5 1.3 0.38 9.3 0.9 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) EMP24_GP25L PF01105.19 CCF35443.1 - 0.59 9.8 3.2 0.8 9.4 2.2 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DivIC PF04977.10 CCF35443.1 - 0.93 9.0 4.7 1.7 8.1 3.3 1.4 1 0 0 1 1 1 0 Septum formation initiator DUF972 PF06156.8 CCF35443.1 - 1 9.7 4.0 1.3 9.4 2.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Packaging_FI PF14000.1 CCF35443.1 - 9.2 6.4 10.4 0.48 10.6 2.7 2.0 1 1 1 2 2 2 0 DNA packaging protein FI Ion_trans PF00520.26 CCF35444.1 - 4.4e-08 32.6 5.3 7.6e-08 31.8 3.7 1.4 1 0 0 1 1 1 1 Ion transport protein Herpes_BLRF2 PF05812.7 CCF35444.1 - 0.32 10.8 2.9 0.61 9.9 2.0 1.5 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein Sugarporin_N PF11471.3 CCF35444.1 - 0.62 9.7 5.4 1.4 8.6 3.7 1.6 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Sugar_tr PF00083.19 CCF35445.1 - 1.5e-124 416.0 22.8 1.7e-124 415.8 15.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF35445.1 - 9.2e-26 90.3 38.7 9.8e-21 73.8 10.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily RhodobacterPufX PF11511.3 CCF35445.1 - 0.067 12.5 3.2 1.5 8.2 0.1 3.3 3 0 0 3 3 3 0 Intrinsic membrane protein PufX His_Phos_2 PF00328.17 CCF35447.1 - 5.5e-54 183.8 0.0 6.5e-54 183.5 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) ABC2_membrane_3 PF12698.2 CCF35447.1 - 1.1 8.2 3.2 2 7.3 2.2 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein zf-LITAF-like PF10601.4 CCF35448.1 - 5e-10 39.1 2.9 0.00017 21.3 0.2 2.4 1 1 1 2 2 2 2 LITAF-like zinc ribbon domain Totivirus_coat PF05518.6 CCF35448.1 - 6.7 4.4 10.9 7.7 4.2 7.6 1.2 1 0 0 1 1 1 0 Totivirus coat protein Cyt-b5 PF00173.23 CCF35449.1 - 2.2e-16 59.4 0.0 5.4e-16 58.1 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FAD_binding_1 PF00667.15 CCF35449.1 - 2.3e-12 46.8 0.0 4.8e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 CCF35449.1 - 8.7e-09 35.9 0.0 2.7e-08 34.3 0.0 1.9 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain CBM_1 PF00734.13 CCF35450.1 - 3.7e-11 42.4 4.9 3.7e-11 42.4 3.4 2.7 2 0 0 2 2 2 1 Fungal cellulose binding domain Glyco_hydro_12 PF01670.11 CCF35450.1 - 1e-10 41.6 0.0 1.7e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 DUF3439 PF11921.3 CCF35450.1 - 0.68 9.6 7.5 4.3 7.1 5.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Glyco_hydro_12 PF01670.11 CCF35451.1 - 2.1e-16 60.0 0.2 2.5e-16 59.8 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 MFS_1 PF07690.11 CCF35453.1 - 4e-43 147.4 15.2 4e-43 147.4 10.5 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF35453.1 - 2.4e-15 56.0 0.8 2.4e-15 56.0 0.6 2.0 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.15 CCF35453.1 - 0.00052 18.2 0.2 0.41 8.6 0.3 3.0 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF953 PF06110.6 CCF35454.1 - 8.5e-17 60.6 0.0 9.9e-17 60.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_9 PF14595.1 CCF35454.1 - 0.0065 16.0 0.0 0.01 15.4 0.0 1.4 1 1 0 1 1 1 1 Thioredoxin FGE-sulfatase PF03781.11 CCF35455.1 - 1.9e-40 138.8 1.7 2.7e-40 138.3 1.1 1.1 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 AAA_16 PF13191.1 CCF35455.1 - 9.7e-05 22.4 0.6 0.0086 16.0 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 CCF35455.1 - 0.0002 22.1 0.0 0.00039 21.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 CCF35455.1 - 0.00031 20.1 0.0 0.0008 18.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 CCF35455.1 - 0.00055 19.6 0.0 0.0013 18.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_19 PF13245.1 CCF35455.1 - 0.0011 18.6 0.0 0.0049 16.5 0.0 2.2 2 0 0 2 2 1 1 Part of AAA domain AAA_33 PF13671.1 CCF35455.1 - 0.0047 16.8 0.0 0.012 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CCF35455.1 - 0.0064 16.6 0.1 0.027 14.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 CCF35455.1 - 0.011 15.1 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_29 PF13555.1 CCF35455.1 - 0.014 14.9 0.1 0.034 13.6 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain UPF0079 PF02367.12 CCF35455.1 - 0.017 14.7 0.0 0.029 13.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_18 PF13238.1 CCF35455.1 - 0.018 15.3 0.0 0.031 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 CCF35455.1 - 0.021 15.1 0.0 0.032 14.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain CbiA PF01656.18 CCF35455.1 - 0.033 13.5 1.0 0.063 12.6 0.7 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain IstB_IS21 PF01695.12 CCF35455.1 - 0.041 13.3 0.0 0.072 12.5 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.22 CCF35455.1 - 0.044 14.0 0.0 0.099 12.9 0.0 1.5 1 0 0 1 1 1 0 ABC transporter cobW PF02492.14 CCF35455.1 - 0.049 13.0 0.0 0.078 12.4 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain T2SE PF00437.15 CCF35455.1 - 0.052 12.4 0.0 0.081 11.8 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA PF00004.24 CCF35455.1 - 0.059 13.5 0.0 0.098 12.8 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MobB PF03205.9 CCF35455.1 - 0.067 12.8 0.0 0.19 11.4 0.0 1.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 CCF35455.1 - 0.072 13.2 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.10 CCF35455.1 - 0.076 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 NTPase AAA_5 PF07728.9 CCF35455.1 - 0.076 12.7 0.1 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Calici_MSP PF05752.6 CCF35455.1 - 0.084 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Calicivirus minor structural protein APS_kinase PF01583.15 CCF35455.1 - 0.15 11.7 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase KaiC PF06745.8 CCF35455.1 - 0.17 11.0 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 KaiC Pox_A32 PF04665.7 CCF35455.1 - 0.24 10.6 0.1 0.4 9.9 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein G-alpha PF00503.15 CCF35455.1 - 0.29 9.7 0.0 0.55 8.8 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit MFS_1 PF07690.11 CCF35456.1 - 6.6e-27 94.1 29.0 6.6e-27 94.1 20.1 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF35456.1 - 0.0016 18.1 0.7 0.0061 16.3 0.3 2.1 2 0 0 2 2 2 1 MFS_1 like family Methyltransf_23 PF13489.1 CCF35457.1 - 1.5e-18 67.0 0.0 2.2e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF35457.1 - 9.2e-12 44.7 0.0 4.3e-11 42.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF35457.1 - 9.4e-10 39.0 0.0 1.5e-08 35.1 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF35457.1 - 9.4e-10 38.8 0.0 3.4e-09 37.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF35457.1 - 1e-06 29.1 0.0 2.6e-05 24.5 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF35457.1 - 0.0011 19.0 0.0 0.005 16.8 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF35457.1 - 0.0024 18.1 0.0 0.0054 17.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF35457.1 - 0.0034 16.4 0.0 0.007 15.4 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.14 CCF35457.1 - 0.0072 16.3 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.9 CCF35457.1 - 0.0088 15.4 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 CCF35457.1 - 0.01 14.9 0.0 0.02 14.0 0.0 1.4 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.4 CCF35457.1 - 0.02 14.3 0.0 0.033 13.6 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_2 PF00891.13 CCF35457.1 - 0.024 13.8 0.0 0.04 13.1 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Beta-lactamase PF00144.19 CCF35458.1 - 7e-51 173.1 0.2 8.8e-51 172.8 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase Ldl_recept_a PF00057.13 CCF35459.1 - 0.099 12.5 0.3 0.099 12.5 0.2 1.7 2 0 0 2 2 2 0 Low-density lipoprotein receptor domain class A adh_short PF00106.20 CCF35460.1 - 7.6e-15 55.2 0.2 1.2e-14 54.5 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF35460.1 - 1.4e-05 24.9 0.0 2.2e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF35460.1 - 3.3e-05 23.6 0.1 9.7e-05 22.1 0.0 1.7 1 1 1 2 2 2 1 KR domain Epimerase PF01370.16 CCF35460.1 - 0.00067 19.1 0.1 0.0014 18.1 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_PK PF05891.7 CCF35460.1 - 0.022 14.0 0.0 0.036 13.3 0.0 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Polysacc_synt_2 PF02719.10 CCF35460.1 - 0.12 11.2 0.0 0.21 10.4 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein AAA PF00004.24 CCF35461.1 - 4.7e-18 65.6 0.0 7.9e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CCF35461.1 - 1.7e-05 25.6 0.2 0.00016 22.4 0.0 2.6 3 0 0 3 3 3 1 AAA domain RuvB_N PF05496.7 CCF35461.1 - 0.0014 17.7 0.0 0.0025 16.9 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_18 PF13238.1 CCF35461.1 - 0.0014 18.8 0.3 0.016 15.4 0.0 2.7 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.1 CCF35461.1 - 0.0015 18.5 0.2 0.0065 16.4 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CCF35461.1 - 0.0025 17.9 0.0 0.011 15.8 0.0 1.9 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.1 CCF35461.1 - 0.022 14.5 0.2 0.06 13.1 0.2 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA_5 PF07728.9 CCF35461.1 - 0.032 13.9 0.1 0.093 12.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF2968 PF11180.3 CCF35463.1 - 0.049 13.0 0.1 0.096 12.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Transferase PF02458.10 CCF35464.1 - 4.7e-39 134.0 0.0 1.4e-16 59.9 0.0 3.1 3 0 0 3 3 3 3 Transferase family DUF1195 PF06708.6 CCF35464.1 - 0.0064 15.9 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1195) Apo-VLDL-II PF05418.6 CCF35464.1 - 0.15 12.2 0.0 0.46 10.6 0.0 1.8 2 0 0 2 2 2 0 Apovitellenin I (Apo-VLDL-II) Leu_zip PF15294.1 CCF35466.1 - 0.0079 15.3 0.3 0.013 14.5 0.2 1.3 1 0 0 1 1 1 1 Leucine zipper DivIC PF04977.10 CCF35466.1 - 0.021 14.2 0.3 0.021 14.2 0.2 1.9 3 0 0 3 3 3 0 Septum formation initiator Shugoshin_N PF07558.6 CCF35466.1 - 0.065 12.9 3.7 0.043 13.5 1.2 1.7 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region FlaC_arch PF05377.6 CCF35466.1 - 0.12 12.2 0.7 0.26 11.1 0.5 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) ATG16 PF08614.6 CCF35466.1 - 0.59 9.9 6.1 0.16 11.8 0.5 2.2 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Uds1 PF15456.1 CCF35466.1 - 7.9 6.4 9.5 0.36 10.8 0.3 2.4 3 0 0 3 3 3 0 Up-regulated During Septation Nop14 PF04147.7 CCF35467.1 - 3.8 5.3 65.6 5.4 4.7 45.5 1.2 1 0 0 1 1 1 0 Nop14-like family UDPG_MGDP_dh_N PF03721.9 CCF35469.1 - 1.2e-48 164.9 0.0 6.6e-35 120.1 0.0 2.6 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.14 CCF35469.1 - 9.4e-30 102.6 0.0 1.9e-29 101.7 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.10 CCF35469.1 - 9.5e-24 83.5 0.0 1e-17 64.1 0.0 3.4 3 0 0 3 3 3 3 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_Gly3P_dh_N PF01210.18 CCF35469.1 - 0.00018 21.2 1.6 0.069 12.8 0.3 3.7 2 1 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.10 CCF35469.1 - 0.0054 16.5 0.0 0.38 10.5 0.0 3.2 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Saccharop_dh PF03435.13 CCF35469.1 - 0.097 11.6 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase DUF336 PF03928.9 CCF35470.1 - 1.4e-18 66.9 0.0 2e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF336) Glyco_hydro_7 PF00840.15 CCF35471.1 - 3.8e-146 486.8 3.0 4.8e-146 486.5 2.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 Secretogranin_V PF05281.6 CCF35471.1 - 0.16 11.3 1.7 0.25 10.6 1.2 1.2 1 0 0 1 1 1 0 Neuroendocrine protein 7B2 precursor (Secretogranin V) WD40 PF00400.27 CCF35472.1 - 6e-49 162.2 21.2 9.1e-10 38.0 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 CCF35472.1 - 0.0001 22.0 0.0 0.098 12.3 0.0 2.8 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A HSA PF07529.8 CCF35473.1 - 2.5e-18 65.6 2.5 2.5e-18 65.6 1.8 4.5 4 0 0 4 4 4 1 HSA Myb_DNA-bind_6 PF13921.1 CCF35473.1 - 2.7e-14 53.0 0.8 9.8e-14 51.2 0.6 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 CCF35473.1 - 0.0033 17.4 0.1 0.0099 15.9 0.1 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain SAM_decarbox PF01536.11 CCF35474.1 - 7.4e-86 287.8 0.0 3.4e-63 213.3 0.0 3.8 1 1 0 2 2 2 2 Adenosylmethionine decarboxylase TYA PF01021.14 CCF35475.1 - 0.11 12.6 0.4 0.25 11.5 0.3 1.5 1 0 0 1 1 1 0 TYA transposon protein COesterase PF00135.23 CCF35476.1 - 2.6e-72 244.2 0.0 3.3e-72 243.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF35476.1 - 5e-07 29.5 0.0 6.7e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Asn_synthase PF00733.16 CCF35477.1 - 1.3e-56 191.9 0.0 1.9e-56 191.4 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 CCF35477.1 - 9.4e-08 31.8 0.0 6.9e-07 29.0 0.0 2.3 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 CCF35477.1 - 0.00071 19.5 0.0 0.0016 18.3 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3176 PF11374.3 CCF35478.1 - 1.5e-32 111.7 0.7 1.5e-32 111.7 0.5 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3176) Mito_carr PF00153.22 CCF35479.1 - 9.2e-51 169.5 7.8 1.3e-18 66.5 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein CBS PF00571.23 CCF35481.1 - 5.4e-05 22.8 0.1 0.39 10.5 0.0 3.1 1 1 1 2 2 2 2 CBS domain Spindle_Spc25 PF08234.7 CCF35481.1 - 0.038 13.9 0.0 0.11 12.4 0.0 1.7 2 0 0 2 2 2 0 Chromosome segregation protein Spc25 Epimerase PF01370.16 CCF35483.1 - 1.4e-23 83.5 0.0 2e-23 83.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 CCF35483.1 - 5.1e-10 38.6 0.0 8.4e-10 37.9 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.20 CCF35483.1 - 1.3e-07 31.6 0.0 9.2e-07 28.9 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.1 CCF35483.1 - 2.7e-05 24.2 0.0 5.1e-05 23.3 0.0 1.5 1 1 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 CCF35483.1 - 0.00062 18.5 0.0 0.0024 16.6 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Saccharop_dh PF03435.13 CCF35483.1 - 0.00065 18.7 0.0 0.001 18.1 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase KR PF08659.5 CCF35483.1 - 0.0012 18.5 0.0 0.002 17.7 0.0 1.4 1 0 0 1 1 1 1 KR domain TrkA_N PF02254.13 CCF35483.1 - 0.011 15.7 0.0 0.025 14.5 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_4 PF07993.7 CCF35483.1 - 0.023 13.6 0.0 0.051 12.4 0.0 1.6 1 0 0 1 1 1 0 Male sterility protein Semialdhyde_dh PF01118.19 CCF35483.1 - 0.11 12.8 0.1 0.64 10.3 0.0 2.3 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain F_actin_cap_B PF01115.12 CCF35485.1 - 3e-108 360.6 0.0 3.4e-108 360.4 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit P3A PF08727.6 CCF35485.1 - 0.11 11.8 0.0 0.23 10.8 0.0 1.5 1 0 0 1 1 1 0 Poliovirus 3A protein like Rpn3_C PF08375.6 CCF35486.1 - 4.5e-24 84.6 1.5 4.5e-24 84.6 1.0 2.2 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.22 CCF35486.1 - 3.8e-20 72.1 0.2 1.3e-19 70.4 0.0 2.0 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.12 CCF35486.1 - 0.0065 16.3 0.1 0.022 14.6 0.1 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat UDPGT PF00201.13 CCF35487.1 - 5.8e-09 35.0 0.0 8.6e-09 34.4 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Pyridox_oxidase PF01243.15 CCF35488.1 - 0.00036 20.4 0.0 0.011 15.7 0.0 2.3 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase FAD_binding_6 PF00970.19 CCF35488.1 - 0.077 13.1 0.0 0.55 10.3 0.0 2.3 1 1 0 1 1 1 0 Oxidoreductase FAD-binding domain VirB3 PF05101.8 CCF35489.1 - 7 6.7 8.4 0.13 12.2 0.7 1.9 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein NmrA PF05368.8 CCF35490.1 - 5.4e-17 61.8 0.0 7.2e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF35490.1 - 5.9e-12 45.9 0.1 7.8e-12 45.5 0.1 1.1 1 0 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 CCF35490.1 - 0.04 12.8 0.0 0.067 12.1 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase Epimerase PF01370.16 CCF35490.1 - 0.064 12.6 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family FSH1 PF03959.8 CCF35491.1 - 2.7e-32 111.9 0.0 5.2e-32 111.0 0.0 1.5 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.2 CCF35491.1 - 7.8e-10 39.0 1.4 1.2e-09 38.4 1.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF35491.1 - 3.6e-06 26.7 0.0 6.5e-06 25.9 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 CCF35491.1 - 0.15 11.4 0.6 0.4 10.0 0.1 1.9 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase C1_2 PF03107.11 CCF35493.1 - 0.01 15.9 0.7 0.02 15.0 0.5 1.4 1 0 0 1 1 1 0 C1 domain HLH PF00010.21 CCF35494.1 - 0.012 15.3 0.2 0.57 9.9 0.1 2.3 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain DUF1786 PF08735.5 CCF35495.1 - 0.022 13.9 0.0 0.034 13.3 0.0 1.2 1 0 0 1 1 1 0 Putative pyruvate format-lyase activating enzyme (DUF1786) Peptidase_C1_2 PF03051.10 CCF35496.1 - 6.4e-126 420.4 0.0 7.4e-126 420.1 0.0 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.18 CCF35496.1 - 0.0024 17.7 0.0 1.4 8.7 0.0 2.4 2 1 0 2 2 2 2 Papain family cysteine protease TPT PF03151.11 CCF35497.1 - 4.4e-16 58.8 10.8 4.4e-16 58.8 7.5 2.8 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 CCF35497.1 - 1.4e-05 25.1 9.4 1.4e-05 25.1 6.5 2.6 2 1 0 2 2 2 1 EamA-like transporter family Brix PF04427.13 CCF35498.1 - 4.4e-37 127.5 0.5 7.5e-37 126.8 0.4 1.3 1 0 0 1 1 1 1 Brix domain Nop14 PF04147.7 CCF35498.1 - 0.04 11.8 26.7 0.056 11.3 18.5 1.1 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.7 CCF35498.1 - 8.6 5.9 27.5 16 5.1 19.1 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein HTH_psq PF05225.11 CCF35499.1 - 0.045 13.3 0.0 0.066 12.7 0.0 1.3 1 0 0 1 1 1 0 helix-turn-helix, Psq domain Sugar_tr PF00083.19 CCF35500.1 - 1.6e-85 287.3 25.2 1.8e-85 287.1 17.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF35500.1 - 3.7e-26 91.6 32.2 2e-24 85.9 16.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF35500.1 - 5.7e-08 31.4 1.7 5.7e-08 31.4 1.2 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Gate PF07670.9 CCF35500.1 - 2.6 7.9 9.7 0.39 10.6 2.3 2.7 2 1 0 2 2 2 0 Nucleoside recognition Cellulase PF00150.13 CCF35501.1 - 3.3e-31 108.5 3.2 4.3e-31 108.1 2.2 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) AP_endonuc_2 PF01261.19 CCF35501.1 - 0.026 13.8 0.0 0.068 12.4 0.0 1.7 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel MFS_1 PF07690.11 CCF35502.1 - 8.9e-15 54.2 53.8 2.6e-09 36.2 10.8 2.3 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF35502.1 - 5.3e-07 28.2 22.4 9.4e-07 27.4 15.5 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OppC_N PF12911.2 CCF35502.1 - 1.9 7.8 5.8 1.8 8.0 1.1 3.2 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C Methyltransf_23 PF13489.1 CCF35503.1 - 3.6e-11 43.0 0.0 6.5e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF35503.1 - 0.013 16.0 0.0 0.1 13.0 0.0 2.2 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.7 CCF35503.1 - 0.022 15.2 0.0 0.14 12.6 0.0 2.2 2 1 0 2 2 2 0 Methyltransferase domain POP1 PF06978.6 CCF35504.1 - 1.3e-63 214.0 15.0 1.3e-63 214.0 10.4 2.3 2 0 0 2 2 2 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.7 CCF35504.1 - 9e-28 95.9 0.2 2.6e-27 94.5 0.1 1.8 1 0 0 1 1 1 1 POPLD (NUC188) domain GCV_T_C PF08669.6 CCF35504.1 - 0.061 13.3 0.0 0.24 11.4 0.0 2.1 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain Adeno_terminal PF02459.10 CCF35504.1 - 2.2 6.3 8.0 3.7 5.6 5.5 1.3 1 0 0 1 1 1 0 Adenoviral DNA terminal protein Terminase_1 PF03354.10 CCF35505.1 - 0.0087 14.5 2.5 0.012 14.0 1.7 1.1 1 0 0 1 1 1 1 Phage Terminase Peptidase_S8 PF00082.17 CCF35506.1 - 6.7e-41 140.2 9.3 1.1e-40 139.5 6.5 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 CCF35506.1 - 1e-14 54.8 0.1 1.7e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Abhydrolase_6 PF12697.2 CCF35507.1 - 1.1e-10 41.7 0.1 0.00014 21.8 0.0 3.1 2 1 0 2 2 2 2 Alpha/beta hydrolase family PGAP1 PF07819.8 CCF35507.1 - 3.1e-09 36.7 0.1 0.00099 18.7 0.0 2.5 2 0 0 2 2 2 2 PGAP1-like protein Abhydrolase_5 PF12695.2 CCF35507.1 - 8e-08 32.1 0.0 0.017 14.8 0.0 3.2 2 1 0 2 2 2 2 Alpha/beta hydrolase family DUF676 PF05057.9 CCF35507.1 - 6.9e-07 28.7 0.1 0.0011 18.2 0.0 2.5 2 0 0 2 2 2 2 Putative serine esterase (DUF676) NACHT PF05729.7 CCF35507.1 - 1.7e-05 24.5 0.0 4.9e-05 23.0 0.0 1.8 1 0 0 1 1 1 1 NACHT domain DUF900 PF05990.7 CCF35507.1 - 3.1e-05 23.4 0.3 0.013 14.8 0.0 2.9 2 1 1 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF900) LCAT PF02450.10 CCF35507.1 - 0.00038 19.5 0.0 0.11 11.4 0.0 2.4 2 0 0 2 2 2 2 Lecithin:cholesterol acyltransferase AAA_33 PF13671.1 CCF35507.1 - 0.00086 19.1 0.0 0.12 12.2 0.0 3.7 4 0 0 4 4 4 1 AAA domain Ank_2 PF12796.2 CCF35507.1 - 0.00099 19.4 0.0 0.0066 16.7 0.0 2.5 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 CCF35507.1 - 0.0017 18.0 0.6 0.041 13.6 0.0 3.5 4 0 0 4 4 3 1 Ankyrin repeat AAA_16 PF13191.1 CCF35507.1 - 0.0029 17.6 0.0 0.014 15.4 0.0 2.2 1 0 0 1 1 1 1 AAA ATPase domain UPF0565 PF10561.4 CCF35507.1 - 0.0065 15.4 0.0 1 8.2 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised protein family UPF0565 DUF829 PF05705.9 CCF35507.1 - 0.015 14.9 0.1 0.12 12.0 0.0 2.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF829) Ank_4 PF13637.1 CCF35507.1 - 0.019 15.4 0.0 0.12 12.9 0.0 2.5 2 0 0 2 2 1 0 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF35507.1 - 0.03 14.5 0.0 0.19 12.0 0.0 2.5 2 0 0 2 2 1 0 Ankyrin repeats (many copies) ABC_tran PF00005.22 CCF35507.1 - 0.054 13.8 0.0 0.28 11.4 0.0 2.1 2 0 0 2 2 2 0 ABC transporter MMR_HSR1 PF01926.18 CCF35507.1 - 0.078 12.9 0.0 0.53 10.2 0.0 2.4 3 0 0 3 3 3 0 50S ribosome-binding GTPase Cutinase PF01083.17 CCF35507.1 - 0.097 12.4 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 Cutinase AAA_18 PF13238.1 CCF35507.1 - 0.13 12.6 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain NAD_binding_2 PF03446.10 CCF35508.1 - 9.5e-20 71.0 0.0 1.6e-19 70.3 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 CCF35508.1 - 1.1e-09 38.3 0.0 2.1e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase DUF2580 PF10824.3 CCF35508.1 - 0.15 12.4 1.5 0.17 12.2 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2580) MFS_1 PF07690.11 CCF35509.1 - 5.9e-32 110.7 26.2 8.9e-32 110.1 18.0 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily PCI PF01399.22 CCF35510.1 - 1.3e-16 60.8 0.5 7.5e-16 58.3 0.1 2.4 3 0 0 3 3 3 1 PCI domain AnfO_nitrog PF09582.5 CCF35510.1 - 0.0055 15.8 0.6 0.43 9.6 0.1 2.3 2 0 0 2 2 2 2 Iron only nitrogenase protein AnfO (AnfO_nitrog) DUF3546 PF12066.3 CCF35511.1 - 5.6e-26 90.7 1.5 5.6e-26 90.7 1.1 2.1 3 0 0 3 3 3 1 Domain of unknown function (DUF3546) DUF4187 PF13821.1 CCF35511.1 - 6.2e-24 83.3 0.1 1.5e-23 82.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) ARS2 PF04959.8 CCF35511.1 - 6.9e-12 46.0 0.1 1.7e-11 44.7 0.1 1.6 1 0 0 1 1 1 1 Arsenite-resistance protein 2 TspO_MBR PF03073.10 CCF35512.1 - 1.4e-41 141.5 6.7 1.7e-41 141.2 4.6 1.1 1 0 0 1 1 1 1 TspO/MBR family Mito_carr PF00153.22 CCF35513.1 - 7.4e-60 198.6 0.1 3.1e-22 78.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DEAD PF00270.24 CCF35514.1 - 9e-42 142.4 0.0 6.7e-41 139.5 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF35514.1 - 2.5e-26 91.3 0.3 6.2e-26 90.0 0.2 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF35514.1 - 0.013 15.3 0.4 0.049 13.4 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit zf-CSL PF05207.8 CCF35516.1 - 2e-18 65.6 0.6 3e-18 65.0 0.4 1.3 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.26 CCF35516.1 - 2.5e-14 52.7 0.4 4.3e-14 51.9 0.3 1.4 1 0 0 1 1 1 1 DnaJ domain 14-3-3 PF00244.15 CCF35517.1 - 5.9e-116 385.5 3.0 6.8e-116 385.3 2.1 1.0 1 0 0 1 1 1 1 14-3-3 protein IATP PF04568.7 CCF35518.1 - 2e-19 69.4 0.5 2.3e-19 69.2 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP Pam16 PF03656.8 CCF35518.1 - 0.0037 17.0 0.1 0.0055 16.5 0.1 1.3 1 1 0 1 1 1 1 Pam16 DUF489 PF04356.7 CCF35518.1 - 0.027 14.0 0.4 0.034 13.7 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF489) DUF3233 PF11557.3 CCF35518.1 - 0.07 11.9 0.0 0.083 11.7 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3233) NPV_P10 PF05531.7 CCF35518.1 - 0.1 12.8 0.9 0.15 12.3 0.6 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF1003 PF06210.6 CCF35518.1 - 0.36 10.7 1.7 0.53 10.2 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) Nsp1_C PF05064.8 CCF35519.1 - 1.3e-39 134.4 1.4 3e-39 133.2 1.0 1.5 1 0 0 1 1 1 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.1 CCF35519.1 - 2.1e-23 82.7 231.5 5.5e-10 39.4 29.3 6.6 2 1 5 7 7 6 5 Nucleoporin FG repeat region DUF948 PF06103.6 CCF35519.1 - 0.039 13.8 1.5 0.23 11.3 0.1 2.2 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TMCO5 PF14992.1 CCF35519.1 - 0.085 11.9 4.1 0.12 11.4 2.8 1.1 1 0 0 1 1 1 0 TMCO5 family GAS PF13851.1 CCF35519.1 - 0.37 9.9 6.2 2.2 7.4 0.1 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Laminin_II PF06009.7 CCF35519.1 - 0.56 9.9 3.9 14 5.4 0.4 2.4 2 0 0 2 2 2 0 Laminin Domain II NPV_P10 PF05531.7 CCF35519.1 - 0.58 10.4 2.6 2.9 8.2 0.1 2.8 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein CENP-F_leu_zip PF10473.4 CCF35519.1 - 0.59 9.9 6.8 0.82 9.5 4.4 1.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Exonuc_VII_L PF02601.10 CCF35519.1 - 0.61 9.2 3.6 0.84 8.7 2.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit BLOC1_2 PF10046.4 CCF35519.1 - 2.3 8.3 7.8 10 6.2 0.2 3.0 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tropomyosin PF00261.15 CCF35519.1 - 3.1 6.7 11.3 0.68 8.9 1.8 2.1 1 1 1 2 2 2 0 Tropomyosin APG6 PF04111.7 CCF35519.1 - 3.4 6.6 8.8 21 4.0 6.5 1.6 1 1 1 2 2 2 0 Autophagy protein Apg6 PhyH PF05721.8 CCF35520.1 - 4.7e-17 62.7 0.0 6.9e-17 62.1 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Methyltransf_11 PF08241.7 CCF35521.1 - 4.8e-23 81.4 0.0 8.1e-23 80.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF35521.1 - 1.1e-21 77.0 0.0 1.6e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF35521.1 - 3.7e-16 59.6 0.0 8.4e-16 58.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF35521.1 - 4e-16 58.8 0.0 6.1e-16 58.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 CCF35521.1 - 1.4e-15 57.5 0.0 2.3e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF35521.1 - 1.1e-14 54.4 0.0 1.8e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF35521.1 - 4.7e-13 49.3 0.0 7.5e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF35521.1 - 1e-08 35.2 0.1 1.9e-08 34.3 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 CCF35521.1 - 6.6e-07 29.0 0.1 1.4e-06 27.9 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_29 PF03141.11 CCF35521.1 - 4.8e-06 25.1 0.7 0.0036 15.6 0.0 1.4 1 1 1 2 2 2 2 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.7 CCF35521.1 - 4e-05 23.0 0.0 0.0002 20.7 0.0 1.9 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW RrnaAD PF00398.15 CCF35521.1 - 4.3e-05 22.6 0.0 6.9e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_24 PF13578.1 CCF35521.1 - 4.6e-05 24.1 0.1 0.00012 22.8 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.9 CCF35521.1 - 0.0001 21.7 0.0 0.00014 21.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_PK PF05891.7 CCF35521.1 - 0.0012 18.2 0.0 0.0035 16.6 0.0 1.7 2 0 0 2 2 2 1 AdoMet dependent proline di-methyltransferase Methyltransf_32 PF13679.1 CCF35521.1 - 0.0069 16.0 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.7 CCF35521.1 - 0.011 14.6 0.0 0.023 13.5 0.0 1.5 1 1 0 1 1 1 0 DREV methyltransferase CMAS PF02353.15 CCF35521.1 - 0.018 14.1 0.0 0.024 13.7 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.8 CCF35521.1 - 0.06 12.4 0.0 0.088 11.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.12 CCF35521.1 - 0.069 12.1 0.0 0.15 11.1 0.0 1.5 2 0 0 2 2 2 0 Putative methyltransferase p450 PF00067.17 CCF35522.1 - 3.8e-33 114.6 0.0 5.3e-33 114.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 KR PF08659.5 CCF35523.1 - 1.5e-55 187.6 0.3 6.8e-55 185.5 0.2 2.3 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.16 CCF35523.1 - 4.4e-54 183.9 0.1 1.7e-52 178.7 0.0 2.3 2 0 0 2 2 2 1 Acyl transferase domain PS-DH PF14765.1 CCF35523.1 - 2.1e-48 164.9 1.4 3.6e-48 164.2 1.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.20 CCF35523.1 - 1.9e-43 148.2 0.4 1.9e-43 148.2 0.2 3.1 4 0 0 4 4 4 1 short chain dehydrogenase Methyltransf_12 PF08242.7 CCF35523.1 - 9.9e-19 67.6 0.0 2.5e-18 66.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF35523.1 - 6.9e-15 55.1 0.5 1.4e-14 54.1 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain ADH_zinc_N PF00107.21 CCF35523.1 - 3.8e-10 39.4 0.3 2.8e-09 36.6 0.1 2.5 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF35523.1 - 7.5e-10 39.7 0.1 2.2e-08 35.0 0.0 3.3 3 0 0 3 3 3 1 Zinc-binding dehydrogenase Methyltransf_11 PF08241.7 CCF35523.1 - 2.8e-09 37.3 0.0 9.4e-09 35.6 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF35523.1 - 3.4e-09 36.4 0.0 7.3e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF35523.1 - 7.8e-09 36.1 0.0 3.5e-08 33.9 0.0 2.2 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF35523.1 - 5.3e-06 26.7 0.0 2.5e-05 24.5 0.0 2.3 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF35523.1 - 2.6e-05 23.4 0.0 5.2e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 CCF35523.1 - 0.00056 19.9 0.1 0.0038 17.2 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 CCF35523.1 - 0.0018 17.7 0.0 0.0034 16.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 CCF35523.1 - 0.04 13.4 0.0 0.09 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) ADH_N PF08240.7 CCF35523.1 - 0.18 11.5 0.0 0.42 10.3 0.0 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain DREV PF05219.7 CCF35523.1 - 0.23 10.3 0.0 0.39 9.5 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Polysacc_synt_2 PF02719.10 CCF35523.1 - 0.26 10.1 0.0 0.44 9.3 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein RrnaAD PF00398.15 CCF35523.1 - 0.65 8.9 0.0 1.2 8.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Peptidase_M28 PF04389.12 CCF35524.1 - 2.7e-38 131.5 0.0 3.4e-38 131.1 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 CCF35524.1 - 1.7e-09 37.4 0.0 2.1e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.9 CCF35524.1 - 0.0006 18.6 0.0 0.001 17.9 0.0 1.5 1 1 0 1 1 1 1 M42 glutamyl aminopeptidase MFS_1 PF07690.11 CCF35525.1 - 3.1e-32 111.6 76.0 5.6e-27 94.3 35.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF35525.1 - 0.25 9.8 44.7 0.83 8.1 14.7 2.1 2 0 0 2 2 2 0 Sugar (and other) transporter Cu_amine_oxid PF01179.15 CCF35526.1 - 1.8e-165 550.6 0.0 2.2e-165 550.3 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.11 CCF35526.1 - 2.1e-12 46.9 0.2 3.7e-12 46.1 0.2 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.11 CCF35526.1 - 1.4e-05 25.0 0.0 5.8e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 Copper amine oxidase, N3 domain Methyltransf_23 PF13489.1 CCF35528.1 - 4.6e-12 45.9 0.0 6.6e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF35528.1 - 0.0018 18.7 0.0 0.0032 17.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF35528.1 - 0.0074 15.8 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF35528.1 - 0.019 15.4 0.0 0.036 14.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain DUF3489 PF11994.3 CCF35528.1 - 0.049 13.5 0.0 0.089 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3489) Peptidase_S8 PF00082.17 CCF35533.1 - 9.4e-21 74.1 0.1 1.5e-20 73.4 0.1 1.4 1 0 0 1 1 1 1 Subtilase family DUF1034 PF06280.7 CCF35533.1 - 6.3e-12 45.8 0.0 1.1e-11 45.1 0.0 1.4 1 0 0 1 1 1 1 Fn3-like domain (DUF1034) Phos_pyr_kin PF08543.7 CCF35534.1 - 7.4e-12 44.9 0.0 2e-11 43.5 0.0 1.7 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase PfkB PF00294.19 CCF35534.1 - 3.4e-08 32.9 0.2 9.4e-08 31.5 0.1 1.8 1 1 0 1 1 1 1 pfkB family carbohydrate kinase dUTPase PF00692.14 CCF35535.1 - 9.3e-42 141.5 0.0 1.1e-41 141.2 0.0 1.1 1 0 0 1 1 1 1 dUTPase CENP-K PF11802.3 CCF35536.1 - 1.8e-10 40.5 8.1 0.00018 20.8 0.0 3.0 2 1 0 3 3 3 2 Centromere-associated protein K IncA PF04156.9 CCF35536.1 - 0.0051 16.4 18.1 0.0085 15.7 4.5 2.4 3 0 0 3 3 3 2 IncA protein TACC PF05010.9 CCF35536.1 - 0.11 12.2 7.9 0.13 12.0 4.8 1.6 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) DUF2205 PF10224.4 CCF35536.1 - 0.14 11.7 0.2 0.14 11.7 0.1 2.9 2 1 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) TBPIP PF07106.8 CCF35536.1 - 0.42 10.1 14.2 4.1 6.9 5.8 2.3 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Exonuc_VII_L PF02601.10 CCF35536.1 - 2.3 7.3 11.8 4 6.5 8.2 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF3435 PF11917.3 CCF35536.1 - 3.2 6.3 11.4 0.14 10.8 4.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3435) DivIC PF04977.10 CCF35536.1 - 6.8 6.2 16.0 5.4 6.5 0.9 3.2 2 1 1 3 3 3 0 Septum formation initiator Prefoldin PF02996.12 CCF35536.1 - 8 6.1 11.8 1 9.0 0.4 3.1 2 1 1 3 3 3 0 Prefoldin subunit MAT1 PF06391.8 CCF35536.1 - 8.4 5.9 13.5 4 6.9 5.1 2.7 3 0 0 3 3 3 0 CDK-activating kinase assembly factor MAT1 DSPc PF00782.15 CCF35537.1 - 1.4e-10 40.8 0.0 2.1e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 CCF35537.1 - 0.00039 20.4 0.0 0.00055 20.0 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.22 CCF35537.1 - 0.00043 19.7 0.0 0.00055 19.3 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase MIF4G_like PF09088.6 CCF35538.1 - 6.8e-83 276.7 0.0 1.2e-82 276.0 0.0 1.4 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.6 CCF35538.1 - 5.1e-49 166.7 0.0 7.4e-49 166.2 0.0 1.2 1 0 0 1 1 1 1 MIF4G like WD40 PF00400.27 CCF35539.1 - 3.7e-29 99.5 8.2 4.3e-08 32.7 0.0 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat NLE PF08154.7 CCF35539.1 - 8.4e-20 70.5 0.4 1.5e-19 69.7 0.3 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.3 CCF35539.1 - 5.6e-06 24.7 4.8 0.045 11.8 0.7 3.2 2 1 0 3 3 3 3 Nucleoporin Nup120/160 Chitin_synth_2 PF03142.10 CCF35542.1 - 2.9e-25 88.6 4.3 7.3e-24 84.0 2.0 2.3 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.1 CCF35542.1 - 1.6e-18 67.1 5.7 5.2e-18 65.4 4.0 2.0 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 CCF35542.1 - 1.1e-17 64.5 0.0 2.6e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 CCF35542.1 - 0.0015 18.2 0.1 0.14 11.8 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 Autophagy_act_C PF03987.10 CCF35542.1 - 0.05 13.7 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 Autophagocytosis associated protein, active-site domain HSP70 PF00012.15 CCF35543.1 - 1.8e-163 544.7 4.1 1.8e-163 544.7 2.9 1.9 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 CCF35543.1 - 4e-12 45.3 0.6 2.9e-11 42.5 0.1 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.1 CCF35543.1 - 9.8e-06 25.4 3.5 0.059 13.1 0.3 3.5 2 2 0 2 2 2 2 Cell division protein FtsA Trans_reg_C PF00486.23 CCF35543.1 - 0.08 12.8 0.0 0.27 11.1 0.0 1.9 1 0 0 1 1 1 0 Transcriptional regulatory protein, C terminal GTP_EFTU PF00009.22 CCF35544.1 - 1.2e-32 112.8 0.0 6.9e-32 110.4 0.0 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 CCF35544.1 - 1.2e-18 66.9 0.0 3e-18 65.6 0.0 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 CCF35544.1 - 4e-08 33.2 7.0 2.1e-06 27.7 0.1 3.3 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 CCF35544.1 - 2e-06 27.7 0.2 8.9e-06 25.6 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.12 CCF35544.1 - 0.00093 18.8 0.1 0.0035 16.9 0.0 2.1 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.1 CCF35544.1 - 0.033 14.3 0.1 0.29 11.2 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.1 CCF35544.1 - 0.096 12.6 0.0 0.096 12.6 0.0 3.1 3 0 0 3 3 3 0 AAA ATPase domain SNF2_N PF00176.18 CCF35545.1 - 5.7e-69 232.1 0.0 8.1e-69 231.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CCF35545.1 - 2.1e-10 40.3 0.0 4.3e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.1 CCF35545.1 - 5.7e-08 32.3 2.7 9.8e-08 31.6 1.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 CCF35545.1 - 0.0043 16.6 1.9 0.015 14.9 1.3 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF35545.1 - 0.0056 16.4 1.8 0.013 15.3 1.3 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 CCF35545.1 - 0.019 14.6 2.7 0.091 12.4 1.9 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CCF35545.1 - 0.23 11.5 5.4 0.037 14.0 1.0 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Cyt-b5 PF00173.23 CCF35546.1 - 5.3e-17 61.3 0.0 1.1e-16 60.3 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.19 CCF35546.1 - 1.4e-15 57.4 14.7 1.4e-15 57.4 10.2 1.8 1 1 1 2 2 2 1 Fatty acid desaturase PaRep2a PF07903.6 CCF35548.1 - 0.071 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 PaRep2a protein AHS2 PF02626.10 CCF35549.1 - 1.8e-74 250.4 0.0 2.7e-74 249.9 0.0 1.3 1 0 0 1 1 1 1 Allophanate hydrolase subunit 2 CPSase_L_D2 PF02786.12 CCF35549.1 - 9.8e-54 181.8 0.0 2.4e-53 180.5 0.0 1.6 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 CCF35549.1 - 1.8e-36 124.5 0.1 4.9e-36 123.1 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 CCF35549.1 - 5.4e-31 106.7 0.0 1.2e-30 105.6 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain AHS1 PF02682.11 CCF35549.1 - 8.8e-31 106.9 0.0 2e-30 105.8 0.0 1.6 1 0 0 1 1 1 1 Allophanate hydrolase subunit 1 ATP-grasp_4 PF13535.1 CCF35549.1 - 2.7e-12 46.7 0.0 5.6e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 CCF35549.1 - 1.3e-11 43.8 0.0 1.5e-08 33.7 0.0 3.0 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl PF00364.17 CCF35549.1 - 2e-10 40.1 5.1 2.6e-09 36.5 2.3 3.2 4 0 0 4 4 4 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.8 CCF35549.1 - 3e-05 23.5 0.0 7.3e-05 22.2 0.0 1.6 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 CCF35549.1 - 0.01 15.2 0.0 0.018 14.3 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_5 PF13549.1 CCF35549.1 - 0.01 15.0 0.0 0.022 13.9 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain HET PF06985.6 CCF35550.1 - 8.1e-07 29.2 0.1 1.4e-06 28.5 0.1 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) MatE PF01554.13 CCF35551.1 - 1.1e-49 168.2 35.0 5.1e-31 107.4 7.9 2.4 2 0 0 2 2 2 2 MatE Como_SCP PF02248.11 CCF35551.1 - 0.026 13.8 0.2 0.052 12.9 0.1 1.4 1 0 0 1 1 1 0 Small coat protein Img2 PF05046.9 CCF35552.1 - 4.5e-16 58.8 0.0 5.8e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) SUI1 PF01253.17 CCF35552.1 - 0.0063 16.2 0.0 0.0098 15.6 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 Ldh_1_C PF02866.13 CCF35552.1 - 0.12 12.1 0.0 2.9 7.6 0.0 2.1 1 1 0 1 1 1 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain ARID PF01388.16 CCF35553.1 - 8.8e-19 67.1 0.6 2.7e-18 65.6 0.0 2.2 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain MtaB PF12176.3 CCF35555.1 - 0.12 10.7 0.1 0.13 10.6 0.1 1.1 1 0 0 1 1 1 0 Methanol-cobalamin methyltransferase B subunit Lipoprotein_3 PF00938.12 CCF35555.1 - 0.13 12.0 0.1 0.32 10.7 0.1 1.7 1 1 0 1 1 1 0 Lipoprotein KR PF08659.5 CCF35556.1 - 1e-42 145.8 1.4 2.1e-42 144.8 1.0 1.5 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 CCF35556.1 - 6.7e-38 130.2 2.8 1.6e-37 129.0 2.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase ADH_zinc_N PF00107.21 CCF35556.1 - 6.7e-06 25.6 0.4 5.8e-05 22.6 0.1 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Epimerase PF01370.16 CCF35556.1 - 0.00017 21.1 0.0 0.00034 20.1 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Saccharop_dh PF03435.13 CCF35556.1 - 0.0012 17.8 0.2 0.0026 16.8 0.2 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase ADH_N PF08240.7 CCF35556.1 - 0.0025 17.5 0.0 0.0053 16.4 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short_C2 PF13561.1 CCF35556.1 - 0.026 14.3 0.0 0.095 12.4 0.0 1.8 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase CoA_trans PF01144.18 CCF35556.1 - 0.1 11.7 0.5 0.28 10.3 0.0 1.9 2 0 0 2 2 2 0 Coenzyme A transferase SbcCD_C PF13558.1 CCF35557.1 - 2.2e-12 46.7 0.0 9.4e-12 44.6 0.0 2.2 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_13 PF13166.1 CCF35557.1 - 8.8e-07 27.7 67.2 8.2e-06 24.5 11.7 3.2 1 1 2 3 3 3 3 AAA domain AAA_21 PF13304.1 CCF35557.1 - 2.8e-06 27.5 4.3 1.6e-05 25.0 1.3 2.9 2 1 0 2 2 2 1 AAA domain SMC_N PF02463.14 CCF35557.1 - 0.00075 18.7 19.1 0.0014 17.9 13.2 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain FliJ PF02050.11 CCF35557.1 - 0.012 15.7 57.2 0.25 11.4 8.9 7.2 4 2 4 8 8 8 0 Flagellar FliJ protein Occludin_ELL PF07303.8 CCF35557.1 - 0.034 14.8 0.4 0.034 14.8 0.3 6.7 3 3 5 8 8 8 0 Occludin homology domain DUF948 PF06103.6 CCF35557.1 - 2 8.3 31.5 0.16 11.8 0.2 6.7 6 3 1 7 7 7 0 Bacterial protein of unknown function (DUF948) HCMV_UL139 PF12507.3 CCF35557.1 - 4.9 7.3 17.3 0.042 14.0 3.6 3.6 3 2 0 3 3 3 0 Human Cytomegalovirus UL139 protein Spc7 PF08317.6 CCF35557.1 - 5.5 5.5 70.6 0.58 8.7 4.3 6.0 2 2 4 6 6 6 0 Spc7 kinetochore protein IncA PF04156.9 CCF35557.1 - 8.3 5.9 69.8 0.61 9.6 6.9 5.7 2 1 4 6 6 6 0 IncA protein PPP4R2 PF09184.6 CCF35558.1 - 2e-11 44.0 0.0 2e-11 44.0 0.0 3.4 3 0 0 3 3 3 2 PPP4R2 Pup PF05639.6 CCF35558.1 - 0.96 9.9 0.0 0.96 9.9 0.0 4.3 4 0 0 4 4 4 0 Pup-like protein RRF PF01765.14 CCF35559.1 - 2.6e-19 69.3 2.8 3.2e-19 68.9 2.0 1.1 1 0 0 1 1 1 1 Ribosome recycling factor IFT57 PF10498.4 CCF35559.1 - 0.00096 17.9 1.6 0.0018 17.0 1.1 1.4 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 DUF3533 PF12051.3 CCF35561.1 - 9.2e-97 324.1 6.0 1e-96 323.9 4.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) DUF3046 PF11248.3 CCF35561.1 - 0.006 16.5 0.0 0.018 14.9 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3046) ABC2_membrane_3 PF12698.2 CCF35561.1 - 0.0076 15.3 17.0 0.019 13.9 11.8 1.8 1 1 0 1 1 1 1 ABC-2 family transporter protein GTP_cyclohydro2 PF00925.15 CCF35563.1 - 4.9e-34 117.0 0.2 6.2e-34 116.6 0.1 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase II AA_permease_2 PF13520.1 CCF35564.1 - 5.9e-59 199.6 28.4 8.3e-59 199.2 18.4 2.2 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF35564.1 - 7.7e-12 44.2 19.0 7.7e-12 44.2 13.2 3.1 2 2 0 2 2 2 1 Amino acid permease DHquinase_I PF01487.10 CCF35565.1 - 7.2e-41 140.2 0.0 1.3e-40 139.4 0.0 1.4 1 0 0 1 1 1 1 Type I 3-dehydroquinase Shikimate_dh_N PF08501.6 CCF35565.1 - 5.8e-22 77.5 0.0 1.6e-21 76.1 0.0 1.8 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SKI PF01202.17 CCF35565.1 - 3.8e-16 59.3 0.2 7.5e-16 58.3 0.1 1.5 1 0 0 1 1 1 1 Shikimate kinase Shikimate_DH PF01488.15 CCF35565.1 - 1.1e-10 41.7 0.1 2.5e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_25 PF13481.1 CCF35565.1 - 0.06 12.7 0.1 1.4 8.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain F420_oxidored PF03807.12 CCF35565.1 - 0.12 12.7 0.0 0.46 10.9 0.0 1.9 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent AAA_17 PF13207.1 CCF35565.1 - 0.15 12.8 0.0 0.46 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 CCF35565.1 - 0.15 11.0 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Fungal_trans PF04082.13 CCF35566.1 - 1.2e-09 37.4 0.0 1.8e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF35566.1 - 0.00018 21.3 1.5 0.0004 20.2 1.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1688 PF07958.6 CCF35566.1 - 0.0048 15.4 0.1 0.0071 14.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) Sugar_tr PF00083.19 CCF35567.1 - 2.2e-133 445.1 23.0 2.5e-133 444.9 15.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF35567.1 - 5.7e-23 81.2 32.1 5.7e-23 81.2 22.2 2.2 1 1 0 2 2 2 1 Major Facilitator Superfamily Slu7 PF11708.3 CCF35568.1 - 1.8e-07 31.1 2.5 1.8e-07 31.1 1.7 1.8 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.1 CCF35568.1 - 0.0035 16.9 0.8 0.0068 16.0 0.5 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.18 CCF35568.1 - 0.033 14.1 1.1 0.054 13.4 0.8 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.1 CCF35568.1 - 0.37 10.3 4.1 0.66 9.5 2.9 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger DNA_pol_B PF00136.16 CCF35569.1 - 4.7e-99 332.2 0.0 6.8e-99 331.7 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 CCF35569.1 - 1.1e-19 70.5 0.0 6.3e-09 35.1 0.0 2.4 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 CCF35569.1 - 6.4e-16 58.1 7.8 6.4e-16 58.1 5.4 1.9 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta XkdW PF09636.5 CCF35569.1 - 0.077 12.8 0.2 0.24 11.2 0.1 1.8 1 0 0 1 1 1 0 XkdW protein zf-CHCC PF10276.4 CCF35570.1 - 2.8e-15 55.8 2.2 4.1e-15 55.3 1.5 1.3 1 0 0 1 1 1 1 Zinc-finger domain COX5B PF01215.14 CCF35570.1 - 0.028 14.0 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Vb zf-C2H2_4 PF13894.1 CCF35570.1 - 1.2 9.6 4.2 1.2 9.6 1.7 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger MFS_1 PF07690.11 CCF35571.1 - 4.2e-30 104.6 25.6 1.7e-25 89.4 3.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily zf-CCHC PF00098.18 CCF35572.1 - 8.8e-06 25.4 4.6 1.4e-05 24.7 3.2 1.4 1 0 0 1 1 1 1 Zinc knuckle Nop14 PF04147.7 CCF35572.1 - 0.00071 17.6 13.9 0.00094 17.2 9.7 1.1 1 0 0 1 1 1 1 Nop14-like family Daxx PF03344.10 CCF35572.1 - 0.07 11.6 11.8 0.11 10.9 8.2 1.3 1 0 0 1 1 1 0 Daxx Family CDC45 PF02724.9 CCF35572.1 - 0.24 9.3 10.2 0.34 8.8 7.1 1.2 1 0 0 1 1 1 0 CDC45-like protein FAD_binding_2 PF00890.19 CCF35573.1 - 1.3e-83 281.1 1.1 1.6e-83 280.8 0.8 1.1 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.23 CCF35573.1 - 1.3e-20 72.9 0.2 1.3e-19 69.7 0.0 2.7 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.19 CCF35573.1 - 2.7e-13 49.5 2.9 1.1e-12 47.6 2.0 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 CCF35573.1 - 8.2e-10 38.3 0.7 3.4e-09 36.2 0.5 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF35573.1 - 7.5e-09 35.7 0.0 7.3e-07 29.2 0.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF35573.1 - 2.4e-08 33.8 3.0 1.2e-07 31.6 0.4 2.9 2 1 1 3 3 3 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 CCF35573.1 - 4.2e-05 22.1 3.7 0.0064 15.0 0.3 3.3 3 0 0 3 3 3 1 HI0933-like protein FAD_binding_3 PF01494.14 CCF35573.1 - 6.4e-05 22.1 3.3 0.00023 20.3 2.3 1.7 1 1 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 CCF35573.1 - 0.0001 21.5 1.6 0.013 14.6 0.3 2.8 3 0 0 3 3 3 1 Thi4 family Amino_oxidase PF01593.19 CCF35573.1 - 0.0029 16.7 0.7 0.2 10.6 0.1 2.4 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase GIDA PF01134.17 CCF35573.1 - 0.011 14.6 4.5 0.14 11.0 1.0 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 CCF35573.1 - 0.021 14.8 0.1 0.052 13.6 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF35573.1 - 0.1 13.0 3.1 1.7 9.1 0.6 2.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pkinase PF00069.20 CCF35574.1 - 3.2e-58 196.9 0.0 5.1e-58 196.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF35574.1 - 2.9e-21 75.7 0.1 5.5e-21 74.7 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 CCF35574.1 - 0.0082 15.8 0.0 0.039 13.6 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CCF35574.1 - 0.024 14.1 0.6 0.065 12.7 0.4 1.8 1 0 0 1 1 1 0 Choline/ethanolamine kinase ABC2_membrane PF01061.19 CCF35575.1 - 2.8e-39 134.4 22.6 4.3e-39 133.8 15.7 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 CCF35575.1 - 1e-06 29.1 0.0 1.6e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter PDR_CDR PF06422.7 CCF35575.1 - 0.0052 16.4 0.1 0.0052 16.4 0.1 2.7 3 0 0 3 3 3 1 CDR ABC transporter ABC2_membrane_3 PF12698.2 CCF35575.1 - 0.0091 15.0 12.2 0.013 14.5 8.5 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein SMC_N PF02463.14 CCF35575.1 - 0.07 12.3 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain DHquinase_II PF01220.14 CCF35576.1 - 2.9e-61 204.8 0.2 3.3e-61 204.7 0.1 1.0 1 0 0 1 1 1 1 Dehydroquinase class II ADH_zinc_N PF00107.21 CCF35576.1 - 0.013 15.0 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase ABC_tran PF00005.22 CCF35577.1 - 1.2e-31 109.8 0.0 1.9e-31 109.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 CCF35577.1 - 3.4e-22 79.1 9.5 6.2e-22 78.3 6.6 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 CCF35577.1 - 4.1e-05 22.9 0.0 0.0016 17.7 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF35577.1 - 0.0013 18.7 0.2 0.13 12.2 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF35577.1 - 0.0054 16.7 1.3 0.012 15.6 0.4 1.9 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.18 CCF35577.1 - 0.075 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF87 PF01935.12 CCF35577.1 - 0.2 11.4 0.0 0.43 10.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF87 EF-hand_8 PF13833.1 CCF35578.1 - 0.066 12.8 0.0 0.47 10.1 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_9 PF14658.1 CCF35578.1 - 0.13 12.1 0.0 1.7 8.5 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain IF4E PF01652.13 CCF35579.1 - 2.2e-38 131.4 0.6 2.8e-38 131.0 0.4 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Nitroreductase PF00881.19 CCF35583.1 - 0.059 13.1 0.1 3.1 7.6 0.0 2.4 2 0 0 2 2 2 0 Nitroreductase family NACHT PF05729.7 CCF35584.1 - 5.6e-19 68.4 0.0 1e-18 67.5 0.0 1.4 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.17 CCF35584.1 - 9e-06 24.7 0.0 2.9e-05 23.0 0.0 1.7 1 1 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.1 CCF35584.1 - 6.2e-05 23.1 0.1 0.00031 20.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 CCF35584.1 - 0.00095 19.0 0.0 0.0024 17.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF35584.1 - 0.0022 17.9 0.0 0.2 11.6 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 CCF35584.1 - 0.031 15.0 2.7 0.054 14.3 0.7 2.3 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.1 CCF35584.1 - 0.044 13.1 0.0 0.11 11.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 CCF35584.1 - 0.066 12.9 0.2 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 NTPase AAA_19 PF13245.1 CCF35584.1 - 0.085 12.6 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain AAA_18 PF13238.1 CCF35584.1 - 0.1 12.9 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 CCF35584.1 - 0.14 12.4 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter FtsK_SpoIIIE PF01580.13 CCF35584.1 - 0.19 11.2 0.0 0.32 10.4 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family zf-C3HC4 PF00097.20 CCF35585.1 - 3e-07 29.9 12.8 3e-07 29.9 8.8 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF35585.1 - 1e-06 28.3 12.4 1e-06 28.3 8.6 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 CCF35585.1 - 1.9e-06 27.4 10.4 1.9e-06 27.4 7.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CCF35585.1 - 2.6e-06 27.3 13.1 2.6e-06 27.3 9.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF35585.1 - 6.2e-06 25.9 18.6 1.2e-05 25.0 8.6 2.5 2 0 0 2 2 2 1 Ring finger domain SAP PF02037.22 CCF35585.1 - 1.8e-05 24.0 0.3 3.5e-05 23.1 0.2 1.5 1 0 0 1 1 1 1 SAP domain zf-RING_6 PF14835.1 CCF35585.1 - 8.3e-05 22.2 4.1 8.3e-05 22.2 2.9 1.9 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.1 CCF35585.1 - 0.00014 21.6 12.2 0.00014 21.6 8.5 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 CCF35585.1 - 0.0056 16.3 10.6 0.0056 16.3 7.3 2.7 3 0 0 3 3 3 1 RING-type zinc-finger U-box PF04564.10 CCF35585.1 - 0.0099 15.8 0.0 0.023 14.6 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-rbx1 PF12678.2 CCF35585.1 - 0.039 14.0 9.1 0.051 13.6 4.1 2.3 2 0 0 2 2 2 0 RING-H2 zinc finger Mob_synth_C PF06463.8 CCF35585.1 - 0.2 11.3 3.4 0.44 10.2 2.4 1.5 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C CDC27 PF09507.5 CCF35586.1 - 1.7e-89 301.0 31.8 5.1e-89 299.4 22.0 1.6 1 1 0 1 1 1 1 DNA polymerase subunit Cdc27 Nop14 PF04147.7 CCF35586.1 - 1.9 6.3 16.5 27 2.5 0.0 2.1 2 0 0 2 2 2 0 Nop14-like family DUF1237 PF06824.6 CCF35587.1 - 1.8e-178 593.5 0.0 2.1e-178 593.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1237) Aminotran_1_2 PF00155.16 CCF35588.1 - 8.8e-15 54.5 0.0 1.3e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.2 CCF35588.1 - 1.3e-05 23.9 0.0 0.019 13.5 0.0 2.1 2 0 0 2 2 2 2 Alanine-glyoxylate amino-transferase RNase_Zc3h12a PF11977.3 CCF35588.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Zc3h12a-like Ribonuclease NYN domain MOZ_SAS PF01853.13 CCF35589.1 - 1.2e-85 285.4 0.2 1.9e-85 284.8 0.1 1.2 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.3 CCF35589.1 - 2.5e-17 62.3 0.0 1.4e-16 59.9 0.0 2.2 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.1 CCF35589.1 - 0.059 13.5 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CCF35589.1 - 0.11 12.4 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family RNase_T PF00929.19 CCF35590.1 - 2.2e-26 93.1 0.0 4.2e-26 92.1 0.0 1.5 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.15 CCF35590.1 - 0.00016 21.2 0.0 0.00034 20.1 0.0 1.5 1 1 0 1 1 1 1 3'-5' exonuclease CMAS PF02353.15 CCF35591.1 - 4.4e-71 239.1 0.0 7.8e-71 238.3 0.0 1.3 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 CCF35591.1 - 6.3e-10 39.0 0.0 1.2e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF35591.1 - 7.6e-09 36.1 0.0 1.5e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF35591.1 - 1.1e-08 35.3 0.0 2.2e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF35591.1 - 3.8e-07 29.8 0.0 5.9e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF35591.1 - 2.6e-06 27.4 0.0 4.4e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF35591.1 - 2.3e-05 24.7 0.0 4.5e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 CCF35591.1 - 0.0013 18.2 0.0 0.0027 17.2 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_3 PF01596.12 CCF35591.1 - 0.0025 16.9 0.0 0.0038 16.2 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase MTS PF05175.9 CCF35591.1 - 0.0067 15.8 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain ADH_zinc_N PF00107.21 CCF35591.1 - 0.094 12.2 0.0 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Methyltransf_16 PF10294.4 CCF35591.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase DUF938 PF06080.7 CCF35591.1 - 0.18 11.3 0.0 0.66 9.4 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF938) DAO PF01266.19 CCF35592.1 - 5.7e-12 45.2 3.0 7.4e-12 44.8 2.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF35592.1 - 0.37 10.8 3.7 1.1 9.3 2.5 1.9 1 1 0 1 1 1 0 NAD(P)-binding Rossmann-like domain IPK PF03770.11 CCF35593.1 - 2.8e-57 193.5 0.0 6.5e-57 192.3 0.0 1.6 2 0 0 2 2 2 1 Inositol polyphosphate kinase Herpes_gE PF02480.11 CCF35594.1 - 0.079 11.2 0.1 0.075 11.2 0.0 1.0 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF4658 PF15555.1 CCF35594.1 - 0.08 12.8 0.0 0.08 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4658) SecE PF00584.15 CCF35594.1 - 0.14 11.7 0.8 0.2 11.2 0.5 1.2 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex MFS_1 PF07690.11 CCF35595.1 - 1.7e-35 122.4 59.6 1.3e-30 106.3 25.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1616 PF07760.6 CCF35595.1 - 0.0004 19.6 1.4 0.00085 18.5 0.9 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1616) Myc_N PF01056.13 CCF35595.1 - 0.35 9.9 0.6 0.53 9.3 0.4 1.1 1 0 0 1 1 1 0 Myc amino-terminal region PNK3P PF08645.6 CCF35596.1 - 3.5e-21 75.2 0.0 4.7e-21 74.8 0.0 1.2 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.1 CCF35596.1 - 4.7e-05 23.2 0.0 6.7e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CCF35596.1 - 0.0064 16.6 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 CCF35596.1 - 0.0087 15.1 0.1 0.012 14.6 0.0 1.1 1 0 0 1 1 1 1 Zeta toxin UPF0079 PF02367.12 CCF35596.1 - 0.033 13.8 0.1 0.048 13.2 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 6PF2K PF01591.13 CCF35596.1 - 0.061 12.3 0.1 0.091 11.8 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_16 PF13191.1 CCF35596.1 - 0.13 12.2 0.2 0.21 11.5 0.1 1.3 1 0 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.11 CCF35596.1 - 0.16 11.1 0.1 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF258 MFS_1 PF07690.11 CCF35597.1 - 1.2e-20 73.5 24.9 1.2e-20 73.5 17.3 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF35597.1 - 1.7e-09 36.4 1.4 2.8e-09 35.7 1.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF1418 PF07214.7 CCF35597.1 - 0.057 13.0 0.3 0.057 13.0 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) Pex19 PF04614.7 CCF35598.1 - 9.7e-70 235.0 17.2 9.7e-70 235.0 11.9 1.4 1 1 0 1 1 1 1 Pex19 protein family ABC_tran_2 PF12848.2 CCF35598.1 - 0.12 12.1 6.4 0.49 10.2 0.8 2.5 2 0 0 2 2 2 0 ABC transporter FliE PF02049.13 CCF35598.1 - 5.8 7.0 8.2 4.4 7.3 2.0 3.1 2 1 1 3 3 3 0 Flagellar hook-basal body complex protein FliE ABC1 PF03109.11 CCF35600.1 - 7.7e-31 106.5 0.0 1.5e-30 105.5 0.0 1.5 1 0 0 1 1 1 1 ABC1 family API5 PF05918.6 CCF35600.1 - 2 6.8 5.5 3 6.2 3.8 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) FAD_binding_4 PF01565.18 CCF35601.1 - 2.1e-23 82.3 3.2 4.3e-23 81.3 2.3 1.5 1 0 0 1 1 1 1 FAD binding domain DUF885 PF05960.6 CCF35602.1 - 4.3e-45 154.9 0.0 5.9e-45 154.4 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF885) DUF4253 PF14062.1 CCF35602.1 - 0.016 14.8 0.0 0.047 13.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4253) DnaB PF00772.16 CCF35602.1 - 0.087 12.7 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 DnaB-like helicase N terminal domain G_glu_transpept PF01019.16 CCF35603.1 - 4.1e-13 48.6 0.0 4.5e-13 48.5 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Glycos_transf_1 PF00534.15 CCF35604.1 - 2.4e-20 72.6 0.1 5.1e-20 71.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 CCF35604.1 - 4.7e-10 39.7 0.0 5.6e-09 36.2 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 CCF35604.1 - 0.0034 17.1 0.0 0.006 16.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Metal_CEHH PF14455.1 CCF35604.1 - 0.018 14.4 0.0 0.058 12.7 0.0 1.7 2 0 0 2 2 2 0 Predicted metal binding domain 60KD_IMP PF02096.15 CCF35605.1 - 3.2e-16 59.5 0.4 4.8e-16 59.0 0.3 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein Syntaxin_2 PF14523.1 CCF35606.1 - 1.7e-27 95.3 6.1 1.7e-27 95.3 4.2 2.6 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.14 CCF35606.1 - 1.3e-16 60.0 5.7 5.8e-16 57.9 3.9 2.2 1 0 0 1 1 1 1 SNARE domain Synaptobrevin PF00957.16 CCF35606.1 - 0.0081 15.7 2.0 0.013 15.0 0.4 2.1 2 0 0 2 2 2 1 Synaptobrevin DUF883 PF05957.8 CCF35606.1 - 0.019 15.3 12.5 0.31 11.4 0.0 3.3 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF883) Mnd1 PF03962.10 CCF35606.1 - 0.034 13.7 1.0 0.034 13.7 0.7 2.6 1 1 1 2 2 2 0 Mnd1 family MCPsignal PF00015.16 CCF35606.1 - 0.1 12.1 14.2 3.3 7.1 7.4 2.8 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF342 PF03961.8 CCF35606.1 - 0.11 10.8 6.9 0.96 7.7 0.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF342) DUF1664 PF07889.7 CCF35606.1 - 0.16 11.7 11.0 1.3 8.8 1.9 3.3 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.6 CCF35606.1 - 0.39 11.1 12.5 2.2 8.7 0.0 3.8 3 1 1 4 4 4 0 Syntaxin 6, N-terminal Spectrin PF00435.16 CCF35606.1 - 1.6 9.0 14.4 4.9 7.4 1.6 3.2 2 1 0 2 2 2 0 Spectrin repeat Occludin_ELL PF07303.8 CCF35606.1 - 2.1 9.1 9.2 0.2 12.4 0.7 2.9 2 2 1 3 3 3 0 Occludin homology domain DUF3708 PF12501.3 CCF35606.1 - 4.3 7.1 9.4 1.3e+02 2.3 6.6 2.6 1 1 0 1 1 1 0 Phosphate ATP-binding cassette transporter Tannase PF07519.6 CCF35608.1 - 1e-118 397.0 1.5 1.5e-118 396.5 1.0 1.2 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_1 PF00561.15 CCF35608.1 - 0.00028 20.5 0.1 0.00095 18.7 0.1 1.9 1 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF35608.1 - 0.00029 20.8 0.0 0.00084 19.2 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF35608.1 - 0.00033 20.4 0.1 0.57 9.9 0.0 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase family Ketoacyl-synt_C PF02801.17 CCF35610.1 - 1.1e-41 141.4 0.1 2.6e-41 140.1 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.16 CCF35610.1 - 5e-34 118.0 0.5 1.1e-33 116.9 0.3 1.6 1 0 0 1 1 1 1 Acyl transferase domain MFS_1 PF07690.11 CCF35611.1 - 1.9e-43 148.5 38.4 3.7e-43 147.5 26.6 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF35611.1 - 1.3e-08 33.5 21.4 2.1e-08 32.8 14.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 CCF35611.1 - 4.7e-08 32.0 30.9 2.4e-05 23.0 11.3 2.8 2 2 0 2 2 2 2 Sugar (and other) transporter FSH1 PF03959.8 CCF35612.1 - 8.1e-25 87.5 0.2 1e-23 83.9 0.2 2.4 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.11 CCF35612.1 - 0.0074 15.7 0.2 0.1 12.0 0.0 2.2 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase ketoacyl-synt PF00109.21 CCF35613.1 - 9.5e-78 261.1 0.0 2.9e-77 259.5 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.5 CCF35613.1 - 5.1e-55 185.9 0.3 2.4e-54 183.7 0.1 2.4 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.16 CCF35613.1 - 8.6e-55 186.2 4.3 8.9e-55 186.2 1.5 2.1 2 0 0 2 2 2 1 Acyl transferase domain PS-DH PF14765.1 CCF35613.1 - 9.6e-51 172.6 0.0 1.7e-50 171.8 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.20 CCF35613.1 - 1.1e-38 132.7 0.2 1.4e-37 129.1 0.0 2.7 2 0 0 2 2 2 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 CCF35613.1 - 1.1e-34 118.8 0.2 1.1e-34 118.8 0.1 2.3 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.20 CCF35613.1 - 2.2e-06 27.8 0.1 6.8e-06 26.2 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_zinc_N PF00107.21 CCF35613.1 - 7.5e-06 25.5 0.0 2.1e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Thiolase_N PF00108.18 CCF35613.1 - 1.1e-05 24.5 0.8 0.00039 19.5 0.0 2.5 2 0 0 2 2 2 1 Thiolase, N-terminal domain 3Beta_HSD PF01073.14 CCF35613.1 - 1.3e-05 24.0 0.0 2.6e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family ACP_syn_III PF08545.5 CCF35613.1 - 0.0037 16.8 0.1 0.013 15.1 0.0 2.0 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III RTA1 PF04479.8 CCF35616.1 - 1.9e-29 102.7 4.5 2.5e-29 102.3 3.2 1.1 1 0 0 1 1 1 1 RTA1 like protein Ion_trans PF00520.26 CCF35617.1 - 1e-07 31.4 23.2 3e-07 29.8 13.3 3.0 2 1 0 2 2 2 1 Ion transport protein COesterase PF00135.23 CCF35618.1 - 2.1e-35 122.4 0.0 2.5e-35 122.2 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Crystall PF00030.14 CCF35619.1 - 0.11 12.3 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 Beta/Gamma crystallin IKI3 PF04762.7 CCF35620.1 - 7.5e-15 53.8 0.0 8.2e-15 53.7 0.0 1.0 1 0 0 1 1 1 1 IKI3 family DUF3984 PF13136.1 CCF35621.1 - 9.4e-73 245.2 16.8 1.4e-72 244.7 11.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3984) tRNA-synt_His PF13393.1 CCF35624.1 - 4.3e-41 140.9 0.0 9.2e-35 120.1 0.0 2.2 2 0 0 2 2 2 2 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 CCF35624.1 - 6.3e-19 68.2 0.0 9.5e-19 67.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 CCF35624.1 - 4.9e-11 42.4 0.0 8.8e-11 41.6 0.0 1.4 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.15 CCF35624.1 - 0.0047 15.7 0.1 0.031 13.0 0.0 2.2 2 1 0 2 2 2 1 tRNA synthetases class II (D, K and N) Tmemb_14 PF03647.8 CCF35625.1 - 2.7e-18 66.1 1.0 3.4e-11 43.4 0.2 2.0 2 0 0 2 2 2 2 Transmembrane proteins 14C Gram_pos_anchor PF00746.16 CCF35625.1 - 0.04 13.7 0.1 0.04 13.7 0.1 4.0 5 0 0 5 5 5 0 Gram positive anchor DUF4131 PF13567.1 CCF35625.1 - 0.093 12.1 0.6 0.79 9.1 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) EBP PF05241.7 CCF35626.1 - 5.1e-73 244.2 6.9 6.3e-73 243.9 4.8 1.0 1 0 0 1 1 1 1 Emopamil binding protein PsbN PF02468.10 CCF35626.1 - 5.9 6.5 9.8 0.079 12.5 0.7 2.4 3 0 0 3 3 3 0 Photosystem II reaction centre N protein (psbN) DUF788 PF05620.6 CCF35626.1 - 6.3 6.6 7.6 0.54 10.0 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF788) MFS_1 PF07690.11 CCF35627.1 - 8.8e-26 90.4 20.0 1.2e-25 89.9 13.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF35627.1 - 3.2e-05 22.6 3.7 7.2e-05 21.5 2.5 1.5 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_3 PF05977.8 CCF35627.1 - 0.059 11.4 2.1 0.16 10.0 1.5 1.6 1 1 0 1 1 1 0 Transmembrane secretion effector Cytochrom_B561 PF03188.11 CCF35628.1 - 9.2e-08 32.0 10.9 2e-07 30.8 7.5 1.6 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DUF2427 PF10348.4 CCF35628.1 - 7.8e-05 22.1 1.2 7.8e-05 22.1 0.8 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF2427) DUF3309 PF11752.3 CCF35628.1 - 0.0096 15.6 2.9 0.0096 15.6 2.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3309) DUF4079 PF13301.1 CCF35628.1 - 0.0098 15.9 10.0 0.0098 15.9 6.9 2.1 2 1 1 3 3 3 1 Protein of unknown function (DUF4079) UPF0233 PF06781.7 CCF35628.1 - 0.27 10.8 2.9 0.24 11.0 0.1 2.3 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0233) MNHE PF01899.11 CCF35628.1 - 3.2 7.3 6.5 0.91 9.1 1.9 1.9 1 1 0 1 1 1 0 Na+/H+ ion antiporter subunit DUF2306 PF10067.4 CCF35628.1 - 4.6 7.4 12.3 2.1 8.5 2.7 2.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2306) NAD_binding_5 PF07994.7 CCF35629.1 - 2.2e-07 30.6 0.0 2.3e-07 30.5 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Pectate_lyase PF03211.8 CCF35630.1 - 2.5e-63 213.3 7.8 2.9e-63 213.1 5.4 1.0 1 0 0 1 1 1 1 Pectate lyase IBR PF01485.16 CCF35631.1 - 8.2e-13 48.0 28.6 3.8e-07 29.8 6.8 3.6 3 0 0 3 3 3 2 IBR domain zf-RING_UBOX PF13445.1 CCF35631.1 - 2.1e-07 30.5 2.6 6.3e-07 29.0 1.8 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.1 CCF35631.1 - 3.1e-07 30.3 4.4 3.1e-07 30.3 3.0 3.7 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF35631.1 - 3.6e-06 26.5 3.9 3.6e-06 26.5 2.7 3.6 3 2 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF35631.1 - 5.2e-05 22.8 4.4 5.2e-05 22.8 3.1 4.0 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF35631.1 - 7.7e-05 22.4 3.8 7.7e-05 22.4 2.6 3.6 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_4 PF15227.1 CCF35631.1 - 0.00019 21.2 4.3 0.00019 21.2 3.0 3.7 3 1 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 CCF35631.1 - 0.0035 17.0 3.4 0.0035 17.0 2.3 3.6 3 1 0 3 3 3 1 zinc-RING finger domain FAD_binding_4 PF01565.18 CCF35632.1 - 1.1e-22 79.9 0.7 2.8e-22 78.7 0.5 1.7 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 CCF35632.1 - 0.0054 16.6 0.0 0.014 15.2 0.0 1.7 1 0 0 1 1 1 1 Berberine and berberine like PBP-Tp47_c PF14888.1 CCF35632.1 - 0.044 13.3 0.1 7.5 6.1 0.0 2.5 2 0 0 2 2 2 0 Penicillin-binding protein Tp47 domain C COQ7 PF03232.8 CCF35633.1 - 0.025 14.0 0.1 0.032 13.7 0.1 1.2 1 0 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 DDHD PF02862.12 CCF35633.1 - 0.73 9.5 7.2 0.93 9.2 5.0 1.1 1 0 0 1 1 1 0 DDHD domain MDFI PF15316.1 CCF35633.1 - 1.2 9.1 6.4 1.4 8.8 4.4 1.2 1 0 0 1 1 1 0 MyoD family inhibitor Macoilin PF09726.4 CCF35633.1 - 1.8 6.7 10.9 2 6.6 7.6 1.1 1 0 0 1 1 1 0 Transmembrane protein Dynein_light PF01221.13 CCF35635.1 - 4.5e-41 138.7 1.2 5.2e-41 138.5 0.9 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 RRM_1 PF00076.17 CCF35636.1 - 1.1e-76 252.3 1.3 9.5e-19 66.8 0.0 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF35636.1 - 1.1e-64 214.3 1.2 2.5e-15 56.2 0.0 5.5 5 0 0 5 5 5 5 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF35636.1 - 3e-33 113.4 0.0 4.6e-08 32.7 0.0 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 CCF35636.1 - 3.8e-06 26.5 0.5 3 7.6 0.0 5.3 5 1 0 5 5 5 2 Limkain b1 Nup35_RRM_2 PF14605.1 CCF35636.1 - 7.4e-05 22.4 0.0 2.8 7.7 0.0 3.7 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 CCF35636.1 - 0.00012 21.8 0.8 1.3 8.8 0.0 5.3 5 0 0 5 5 5 1 RNA binding motif RRM_2 PF04059.7 CCF35636.1 - 0.024 14.6 0.0 1.7 8.6 0.0 3.3 3 0 0 3 3 3 0 RNA recognition motif 2 Smg4_UPF3 PF03467.10 CCF35636.1 - 0.03 14.3 0.5 8.9 6.2 0.0 4.1 4 0 0 4 4 4 0 Smg-4/UPF3 family SRP54 PF00448.17 CCF35637.1 - 1.4e-76 256.2 2.7 2e-76 255.8 0.9 1.9 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.14 CCF35637.1 - 7.5e-25 87.1 6.3 7.5e-25 87.1 4.4 3.6 3 1 2 5 5 5 1 Signal peptide binding domain SRP54_N PF02881.14 CCF35637.1 - 1.1e-15 57.4 0.5 3e-15 56.0 0.4 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.14 CCF35637.1 - 1.5e-08 34.2 0.2 4.3e-08 32.8 0.1 1.8 2 0 0 2 2 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 CCF35637.1 - 1.7e-07 31.2 0.0 4.5e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CCF35637.1 - 1.4e-05 25.9 0.0 3.3e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain MobB PF03205.9 CCF35637.1 - 1.5e-05 24.7 0.0 4.2e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B CbiA PF01656.18 CCF35637.1 - 9.8e-05 21.8 0.1 0.00034 20.0 0.1 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 CCF35637.1 - 0.0003 20.7 0.0 0.11 12.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 CCF35637.1 - 0.0014 17.5 0.5 0.0076 15.0 0.4 2.2 1 1 0 1 1 1 1 ArgK protein APS_kinase PF01583.15 CCF35637.1 - 0.0014 18.2 0.0 0.0032 17.1 0.0 1.6 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_22 PF13401.1 CCF35637.1 - 0.0015 18.6 0.0 0.005 16.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF35637.1 - 0.0025 17.8 0.1 0.0062 16.5 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain SRPRB PF09439.5 CCF35637.1 - 0.0029 16.8 0.6 1.6 7.9 0.6 3.2 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit Thymidylate_kin PF02223.12 CCF35637.1 - 0.0037 16.6 0.3 0.011 15.0 0.0 2.0 2 0 0 2 2 2 1 Thymidylate kinase Zeta_toxin PF06414.7 CCF35637.1 - 0.0041 16.2 0.0 0.0083 15.2 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.1 CCF35637.1 - 0.0045 17.3 0.0 0.012 15.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 CCF35637.1 - 0.0048 16.8 0.0 0.034 14.1 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.12 CCF35637.1 - 0.0061 16.1 0.3 0.029 13.9 0.0 2.2 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein TrwB_AAD_bind PF10412.4 CCF35637.1 - 0.017 13.7 0.0 0.036 12.6 0.0 1.5 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_28 PF13521.1 CCF35637.1 - 0.018 14.9 0.1 0.042 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 CCF35637.1 - 0.041 13.3 0.1 0.089 12.2 0.1 1.7 1 1 0 1 1 1 0 AAA-like domain AAA_19 PF13245.1 CCF35637.1 - 0.053 13.2 0.0 0.2 11.4 0.0 2.0 1 0 0 1 1 1 0 Part of AAA domain 6PF2K PF01591.13 CCF35637.1 - 0.053 12.5 0.0 0.091 11.8 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Arf PF00025.16 CCF35637.1 - 0.056 12.6 0.1 0.26 10.4 0.0 2.1 3 0 0 3 3 3 0 ADP-ribosylation factor family AAA PF00004.24 CCF35637.1 - 0.087 13.0 0.5 0.33 11.1 0.3 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.22 CCF35637.1 - 0.11 12.8 0.8 0.31 11.3 0.0 2.1 2 1 0 2 2 2 0 ABC transporter Peptidase_M14 PF00246.19 CCF35638.1 - 8.3e-22 78.0 0.9 1.2e-21 77.5 0.6 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase p450 PF00067.17 CCF35639.1 - 3.5e-52 177.4 0.0 8.1e-52 176.2 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 L6_membrane PF05805.7 CCF35639.1 - 0.18 11.3 0.0 0.48 9.9 0.0 1.6 2 0 0 2 2 2 0 L6 membrane protein 7tm_1 PF00001.16 CCF35640.1 - 0.055 12.6 0.1 0.073 12.2 0.1 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) PH PF00169.24 CCF35641.1 - 0.002 18.2 0.0 0.0042 17.2 0.0 1.6 1 0 0 1 1 1 1 PH domain SAM_2 PF07647.12 CCF35641.1 - 0.01 15.6 0.0 0.023 14.5 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Lactamase_B PF00753.22 CCF35642.1 - 0.048 13.3 0.2 0.048 13.3 0.2 1.1 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Pkinase PF00069.20 CCF35643.1 - 2.9e-34 118.3 0.1 4.6e-25 88.2 0.0 2.5 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 CCF35643.1 - 1.2e-24 86.8 0.0 2.2e-24 85.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 CCF35643.1 - 0.0054 15.8 0.1 0.014 14.4 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Tmemb_cc2 PF10267.4 CCF35643.1 - 0.013 14.1 4.0 0.022 13.3 2.8 1.4 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein HALZ PF02183.13 CCF35643.1 - 0.015 14.9 0.2 0.051 13.2 0.2 1.9 1 0 0 1 1 1 0 Homeobox associated leucine zipper DivIVA PF05103.8 CCF35643.1 - 0.1 12.6 6.2 0.2 11.7 4.3 1.3 1 0 0 1 1 1 0 DivIVA protein GBP_C PF02841.9 CCF35643.1 - 0.23 10.5 7.6 0.37 9.9 5.3 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Atg14 PF10186.4 CCF35643.1 - 0.35 9.7 7.4 0.56 9.0 5.1 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DivIC PF04977.10 CCF35643.1 - 1.4 8.4 10.1 0.085 12.3 0.3 2.3 1 1 1 2 2 2 0 Septum formation initiator DUF972 PF06156.8 CCF35643.1 - 2.6 8.4 6.8 8.6 6.7 4.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DUF1640 PF07798.6 CCF35643.1 - 3.6 7.5 7.3 6.5 6.7 5.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) ADIP PF11559.3 CCF35643.1 - 6.7 6.5 19.4 1 9.2 8.4 2.4 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding DUF3328 PF11807.3 CCF35644.1 - 3.3e-48 164.2 0.6 4e-48 163.9 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Glyco_hydro_97 PF10566.4 CCF35644.1 - 0.03 13.4 0.1 0.041 12.9 0.1 1.2 1 0 0 1 1 1 0 Glycoside hydrolase 97 DctA-YdbH PF11739.3 CCF35645.1 - 0.029 13.8 0.2 38 3.6 0.0 4.1 1 1 5 6 6 6 0 Dicarboxylate transport LpxD PF04613.9 CCF35645.1 - 0.11 12.0 1.7 3.6 7.2 0.0 4.1 7 0 0 7 7 7 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD Trp_DMAT PF11991.3 CCF35646.1 - 9.5e-44 150.0 0.0 1.2e-43 149.7 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase MFS_1 PF07690.11 CCF35647.1 - 2.4e-19 69.2 41.2 3.3e-19 68.8 28.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily COesterase PF00135.23 CCF35648.1 - 2.4e-41 142.0 3.0 1.3e-33 116.5 0.2 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF35648.1 - 1e-06 28.4 0.0 1.7e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF35648.1 - 0.00052 19.7 0.1 0.0015 18.3 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family F-box PF00646.28 CCF35651.1 - 2.7e-06 26.9 0.3 7.3e-06 25.5 0.2 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 CCF35651.1 - 3e-06 26.8 0.6 5.6e-06 25.9 0.4 1.5 1 0 0 1 1 1 1 F-box-like F-box-like_2 PF13013.1 CCF35651.1 - 0.00055 19.6 0.1 0.0014 18.3 0.0 1.7 1 0 0 1 1 1 1 F-box-like domain Spc7 PF08317.6 CCF35651.1 - 0.025 13.2 0.5 0.045 12.4 0.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein ATG16 PF08614.6 CCF35651.1 - 0.68 9.7 10.1 0.096 12.4 3.1 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Baculo_PEP_C PF04513.7 CCF35651.1 - 5.6 6.7 6.4 0.53 10.1 0.8 1.9 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cerato-platanin PF07249.7 CCF35652.1 - 0.00021 21.2 0.5 0.0006 19.7 0.1 1.9 2 0 0 2 2 2 1 Cerato-platanin Amidase PF01425.16 CCF35653.1 - 4.6e-55 187.2 0.1 8.1e-55 186.4 0.0 1.4 1 1 0 1 1 1 1 Amidase Mito_fiss_reg PF05308.6 CCF35654.1 - 0.25 10.6 2.8 0.35 10.1 2.0 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.14 CCF35654.1 - 2.9 7.0 7.9 3.6 6.7 5.4 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Lamp PF01299.12 CCF35654.1 - 4.1 6.4 5.3 5.1 6.1 3.7 1.1 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) FAD-oxidase_C PF02913.14 CCF35655.1 - 2.3e-62 210.5 0.0 3.2e-62 210.0 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 CCF35655.1 - 5.5e-40 136.0 0.0 1e-39 135.1 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain SLA_LP_auto_ag PF05889.8 CCF35655.1 - 0.065 11.6 0.0 0.11 10.9 0.0 1.2 1 0 0 1 1 1 0 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) MFS_1 PF07690.11 CCF35657.1 - 3.4e-34 118.0 29.0 3.4e-34 118.0 20.1 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2964 PF11177.3 CCF35657.1 - 0.021 14.7 1.1 38 4.3 0.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2964) DUF4064 PF13273.1 CCF35657.1 - 0.12 12.4 2.2 9.2 6.4 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) DUF2427 PF10348.4 CCF35657.1 - 1.4 8.5 7.4 1.4 8.5 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF2427) OPT PF03169.10 CCF35658.1 - 9e-96 321.7 26.9 3.6e-49 167.7 7.3 2.0 1 1 1 2 2 2 2 OPT oligopeptide transporter protein Fungal_trans_2 PF11951.3 CCF35659.1 - 1.5e-07 30.4 0.6 2.7e-07 29.5 0.4 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF35659.1 - 1.1e-06 28.4 7.7 2.6e-06 27.2 5.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AAA PF00004.24 CCF35661.1 - 1.9e-17 63.6 0.0 4.1e-17 62.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF35661.1 - 0.00026 21.0 0.0 0.0013 18.7 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.1 CCF35661.1 - 0.0019 18.4 0.4 0.34 11.1 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_17 PF13207.1 CCF35661.1 - 0.0021 18.8 0.2 0.016 16.0 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.1 CCF35661.1 - 0.0032 17.6 0.0 0.018 15.2 0.0 2.1 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.7 CCF35661.1 - 0.013 14.5 0.0 0.022 13.8 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 CCF35661.1 - 0.033 13.9 0.0 0.078 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 CCF35661.1 - 0.039 13.8 0.0 0.12 12.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 CCF35661.1 - 0.075 12.7 0.1 0.18 11.5 0.1 1.6 1 0 0 1 1 1 0 Part of AAA domain tRNA-synt_1g PF09334.6 CCF35666.1 - 3.7e-134 447.2 0.2 4.4e-132 440.4 0.1 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 CCF35666.1 - 2.4e-08 32.4 4.1 0.00052 18.1 0.0 4.2 4 1 1 5 5 5 3 tRNA synthetases class I (I, L, M and V) 3HCDH_N PF02737.13 CCF35666.1 - 1.5 8.4 7.7 2.8 7.5 5.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain WD40 PF00400.27 CCF35667.1 - 3.4e-07 29.8 2.6 0.43 10.5 0.0 5.7 7 0 0 7 7 7 3 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 CCF35667.1 - 0.08 11.2 0.1 0.2 9.9 0.0 1.6 2 0 0 2 2 2 0 Cytochrome D1 heme domain Caps_synth PF05704.7 CCF35671.1 - 1.5e-12 47.2 0.0 2.7e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.10 CCF35671.1 - 1.1e-05 25.6 0.1 2.2e-05 24.7 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 CCF35671.1 - 0.068 11.6 0.1 0.1 11.0 0.1 1.1 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Globin PF00042.17 CCF35672.1 - 4.4e-08 33.4 0.0 7.6e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Globin FAD_binding_6 PF00970.19 CCF35672.1 - 4.4e-06 26.7 0.0 9.9e-06 25.6 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 CCF35672.1 - 0.00015 22.3 0.0 0.00044 20.8 0.0 1.8 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 CCF35672.1 - 0.0086 15.9 0.1 0.049 13.5 0.0 2.2 3 0 0 3 3 3 1 Ferric reductase NAD binding domain Protoglobin PF11563.3 CCF35672.1 - 0.051 13.2 0.0 0.15 11.7 0.0 1.8 1 1 0 1 1 1 0 Protoglobin CENP-Q PF13094.1 CCF35674.1 - 0.59 10.1 17.0 0.052 13.5 3.8 3.6 2 1 1 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit NeA_P2 PF12312.3 CCF35674.1 - 2.4 7.3 5.7 0.51 9.5 0.2 2.2 2 0 0 2 2 2 0 Nepovirus subgroup A polyprotein VIT1 PF01988.14 CCF35674.1 - 2.5 7.5 8.8 7.5 5.9 0.1 2.6 3 0 0 3 3 3 0 VIT family TFIIA PF03153.8 CCF35674.1 - 3.3 7.5 13.3 3.7 7.3 8.8 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CAP_N PF01213.14 CCF35674.1 - 9.8 5.3 12.8 0.24 10.6 0.8 3.0 3 1 0 3 3 3 0 Adenylate cyclase associated (CAP) N terminal AA_permease PF00324.16 CCF35675.1 - 1.9e-43 148.4 11.6 2.5e-43 148.1 8.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF35675.1 - 1.7e-13 49.9 13.9 2.4e-13 49.4 9.6 1.1 1 0 0 1 1 1 1 Amino acid permease Vfa1 PF08432.5 CCF35676.1 - 5.4 7.0 8.6 7.3 6.5 6.0 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Zn_clus PF00172.13 CCF35677.1 - 7.8e-08 32.1 12.3 1.3e-07 31.3 8.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BAF1_ABF1 PF04684.8 CCF35677.1 - 0.001 18.0 7.1 0.0015 17.5 4.9 1.2 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor APC_CDC26 PF10471.4 CCF35677.1 - 0.27 11.9 3.2 0.64 10.7 2.2 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 CPSase_L_D2 PF02786.12 CCF35678.1 - 1.2e-67 227.3 2.3 9.1e-56 188.4 0.1 2.2 1 1 1 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.14 CCF35678.1 - 1.1e-23 83.3 0.0 1.1e-21 76.8 0.0 2.5 1 1 0 1 1 1 1 Biotin carboxylase C-terminal domain CPSase_L_chain PF00289.17 CCF35678.1 - 2.2e-22 79.2 0.0 5.1e-22 78.0 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain HMGL-like PF00682.14 CCF35678.1 - 5.6e-15 55.6 0.0 1.4e-14 54.2 0.0 1.7 2 0 0 2 2 2 1 HMGL-like ATP-grasp_4 PF13535.1 CCF35678.1 - 1.8e-11 44.0 0.1 1.7e-10 40.9 0.0 2.3 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 CCF35678.1 - 1.6e-09 37.0 0.0 0.00022 20.0 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 CCF35678.1 - 0.00047 19.6 0.1 0.0032 16.8 0.0 2.1 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus RimK PF08443.6 CCF35678.1 - 0.00098 18.6 0.1 1.1 8.7 0.0 2.4 2 0 0 2 2 2 2 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 CCF35678.1 - 0.028 14.2 0.0 0.061 13.1 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain Rieske PF00355.21 CCF35678.1 - 0.069 12.7 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Rieske [2Fe-2S] domain PI-PLC-X PF00388.14 CCF35680.1 - 4.2e-58 194.9 0.0 7.4e-58 194.1 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 CCF35680.1 - 2.1e-38 130.9 0.1 4.6e-38 129.8 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.25 CCF35680.1 - 8.1e-10 38.4 0.7 8.3e-09 35.1 0.1 2.4 2 0 0 2 2 2 1 C2 domain EF-hand_like PF09279.6 CCF35680.1 - 0.00093 19.1 0.0 0.0021 18.0 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_8 PF13833.1 CCF35680.1 - 0.0023 17.4 0.0 0.011 15.3 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 CCF35680.1 - 0.0041 16.8 8.3 1 9.4 0.1 4.8 5 0 0 5 5 5 2 EF-hand domain MFS_1 PF07690.11 CCF35681.1 - 2.4e-23 82.4 24.8 2.4e-23 82.4 17.2 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF35681.1 - 2.3e-06 26.4 6.2 2.3e-06 26.4 4.3 2.9 3 0 0 3 3 3 2 Sugar (and other) transporter DUF21 PF01595.15 CCF35681.1 - 0.029 13.6 0.5 0.13 11.5 0.3 2.1 1 0 0 1 1 1 0 Domain of unknown function DUF21 Antimicrobial_6 PF08036.6 CCF35682.1 - 0.026 14.2 1.1 0.062 13.0 0.1 2.1 2 0 0 2 2 2 0 Diapausin family of antimicrobial peptide Ima1_N PF09779.4 CCF35683.1 - 3.7e-24 85.6 1.4 6.4e-24 84.9 1.0 1.4 1 0 0 1 1 1 1 Ima1 N-terminal domain PAP2 PF01569.16 CCF35685.1 - 1.5e-13 50.5 4.4 1.5e-13 50.5 3.1 2.3 1 1 2 3 3 3 1 PAP2 superfamily PAP2_3 PF14378.1 CCF35685.1 - 3.3e-06 26.7 5.7 9.8e-06 25.2 3.9 1.8 1 1 0 1 1 1 1 PAP2 superfamily NADH_dehy_S2_C PF06444.6 CCF35685.1 - 1.2 9.4 6.6 0.15 12.3 0.6 2.3 2 0 0 2 2 2 0 NADH dehydrogenase subunit 2 C-terminus Fer4_2 PF12797.2 CCF35686.1 - 0.03 14.2 16.7 0.19 11.7 0.2 3.0 2 1 1 3 3 3 0 4Fe-4S binding domain A2L_zn_ribbon PF08792.5 CCF35686.1 - 0.2 11.1 2.2 2.6 7.6 0.7 2.4 2 1 0 2 2 2 0 A2L zinc ribbon domain Ribosomal_S27e PF01667.12 CCF35686.1 - 0.42 10.1 7.9 0.24 10.9 2.5 2.0 1 1 1 2 2 2 0 Ribosomal protein S27 Fer4_6 PF12837.2 CCF35686.1 - 0.48 10.3 0.5 0.48 10.3 0.3 3.1 3 0 0 3 3 3 0 4Fe-4S binding domain stn_TNFRSF12A PF12191.3 CCF35686.1 - 0.57 10.2 5.0 0.73 9.8 3.5 1.2 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Fer4 PF00037.22 CCF35686.1 - 0.68 9.6 0.1 0.68 9.6 0.1 2.7 3 0 0 3 3 3 0 4Fe-4S binding domain TFIIS_C PF01096.13 CCF35686.1 - 3.7 7.2 7.9 2.4 7.8 0.1 2.9 2 1 1 3 3 3 0 Transcription factor S-II (TFIIS) Fer4_10 PF13237.1 CCF35686.1 - 8.2 6.3 14.3 6.3 6.6 5.4 2.7 1 1 1 2 2 2 0 4Fe-4S dicluster domain Pkinase PF00069.20 CCF35687.1 - 2.7e-67 226.6 0.0 3.4e-67 226.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF35687.1 - 2.1e-28 99.1 0.0 2.8e-28 98.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF35687.1 - 2e-07 30.3 0.0 2.7e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CCF35687.1 - 0.00031 20.5 0.1 0.00052 19.8 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 CCF35687.1 - 0.0013 17.8 0.0 0.0027 16.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 CCF35687.1 - 0.078 12.3 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RF-1 PF00472.15 CCF35688.1 - 0.03 14.1 0.7 0.032 14.0 0.5 1.0 1 0 0 1 1 1 0 RF-1 domain PRTase_1 PF11202.3 CCF35688.1 - 0.067 12.1 0.6 0.075 11.9 0.4 1.0 1 0 0 1 1 1 0 Phosphoribosyl transferase (PRTase) ATP-synt_E PF05680.7 CCF35688.1 - 0.23 11.4 1.7 0.27 11.2 1.2 1.2 1 0 0 1 1 1 0 ATP synthase E chain adh_short PF00106.20 CCF35689.1 - 2.4e-14 53.5 0.3 4.5e-14 52.7 0.2 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF35689.1 - 9.8e-08 31.8 0.5 1.5e-07 31.2 0.3 1.2 1 0 0 1 1 1 1 KR domain Cutinase PF01083.17 CCF35690.1 - 2.8e-28 98.8 0.1 4.4e-28 98.2 0.1 1.2 1 0 0 1 1 1 1 Cutinase Jacalin PF01419.12 CCF35690.1 - 6e-05 22.9 0.1 9.8e-05 22.2 0.1 1.4 1 0 0 1 1 1 1 Jacalin-like lectin domain FSH1 PF03959.8 CCF35690.1 - 0.0011 18.5 0.1 0.0032 16.9 0.0 1.7 2 0 0 2 2 2 1 Serine hydrolase (FSH1) VirJ PF06057.6 CCF35690.1 - 0.0064 16.2 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) Lipase_3 PF01764.20 CCF35690.1 - 0.0074 15.9 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) DUF3089 PF11288.3 CCF35690.1 - 0.017 14.2 0.0 0.029 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) PE-PPE PF08237.6 CCF35690.1 - 0.023 14.1 0.0 0.033 13.6 0.0 1.2 1 0 0 1 1 1 0 PE-PPE domain Abhydrolase_6 PF12697.2 CCF35690.1 - 0.076 12.8 0.0 0.094 12.5 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family adh_short PF00106.20 CCF35691.1 - 3.4e-06 27.0 0.1 4.3e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.1 CCF35691.1 - 0.00029 20.8 0.0 0.00031 20.8 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding adh_short_C2 PF13561.1 CCF35691.1 - 0.0032 17.2 0.0 0.0035 17.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 CCF35691.1 - 0.044 13.2 0.0 0.044 13.2 0.0 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Saccharop_dh PF03435.13 CCF35691.1 - 0.14 11.1 0.1 0.15 11.0 0.0 1.0 1 0 0 1 1 1 0 Saccharopine dehydrogenase TRAPPC9-Trs120 PF08626.6 CCF35692.1 - 3e-145 485.3 0.0 4.2e-120 402.0 0.0 2.1 2 0 0 2 2 2 2 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Glyco_hydro_63 PF03200.11 CCF35693.1 - 1.2e-46 159.0 0.0 1.4e-46 158.7 0.0 1.0 1 0 0 1 1 1 1 Mannosyl oligosaccharide glucosidase ICMT PF04140.9 CCF35694.1 - 0.13 12.5 0.0 0.17 12.1 0.0 1.1 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family FF PF01846.14 CCF35695.1 - 2e-10 40.4 5.2 3.6e-08 33.2 0.3 3.4 3 0 0 3 3 3 2 FF domain WW PF00397.21 CCF35695.1 - 1.4e-09 37.6 2.4 1.4e-09 37.6 1.7 2.7 2 0 0 2 2 2 1 WW domain Pox_Ag35 PF03286.9 CCF35695.1 - 1.5 8.2 6.7 3.5 7.0 4.7 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PAP2 PF01569.16 CCF35696.1 - 1.8e-23 82.6 1.6 1.8e-23 82.6 1.1 2.1 2 0 0 2 2 2 1 PAP2 superfamily EI24 PF07264.6 CCF35696.1 - 0.11 11.8 2.7 0.078 12.3 0.8 1.5 2 0 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) TM140 PF14985.1 CCF35696.1 - 0.12 12.0 1.5 0.74 9.4 0.1 2.3 1 1 1 2 2 2 0 TM140 protein family Proteasome PF00227.21 CCF35697.1 - 3.1e-60 202.7 0.1 3.8e-60 202.4 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 CCF35697.1 - 2.5e-14 52.2 0.2 6.9e-14 50.8 0.1 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature PHD PF00628.24 CCF35698.1 - 6.2e-10 38.6 8.6 1.4e-09 37.4 6.0 1.7 1 0 0 1 1 1 1 PHD-finger TraH_2 PF06871.6 CCF35698.1 - 0.047 13.1 0.1 0.047 13.1 0.1 2.3 1 1 1 2 2 2 0 TraH_2 PHD_2 PF13831.1 CCF35698.1 - 0.059 12.6 3.6 0.13 11.6 2.5 1.6 1 0 0 1 1 1 0 PHD-finger zf-CW PF07496.10 CCF35698.1 - 0.13 11.9 4.2 0.36 10.5 2.9 1.8 1 0 0 1 1 1 0 CW-type Zinc Finger ECIST_Cterm PF14784.1 CCF35698.1 - 1 9.3 0.0 1 9.3 0.0 2.6 1 1 1 2 2 2 0 C-terminal domain of the ECSIT protein APC_CDC26 PF10471.4 CCF35698.1 - 6.3 7.6 11.3 1.8 9.3 5.2 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 Tyrosinase PF00264.15 CCF35699.1 - 7.6e-19 68.7 2.5 1.2e-18 68.0 1.7 1.4 1 0 0 1 1 1 1 Common central domain of tyrosinase Epimerase_Csub PF13950.1 CCF35699.1 - 0.032 14.1 0.1 0.5 10.3 0.1 2.5 2 0 0 2 2 2 0 UDP-glucose 4-epimerase C-term subunit Methyltransf_2 PF00891.13 CCF35700.1 - 1.9e-28 99.3 0.0 2.8e-28 98.7 0.0 1.4 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_18 PF12847.2 CCF35700.1 - 0.002 18.6 0.0 0.0055 17.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF35700.1 - 0.0081 15.5 0.0 0.021 14.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain PG_binding_1 PF01471.13 CCF35700.1 - 0.025 14.5 0.0 0.05 13.5 0.0 1.5 1 0 0 1 1 1 0 Putative peptidoglycan binding domain Methyltransf_16 PF10294.4 CCF35700.1 - 0.039 13.4 0.0 0.068 12.6 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_4 PF02390.12 CCF35700.1 - 0.057 12.4 0.0 0.13 11.3 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase DNA_binding_1 PF01035.15 CCF35700.1 - 0.096 12.4 0.1 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 6-O-methylguanine DNA methyltransferase, DNA binding domain AflR PF08493.5 CCF35701.1 - 3e-07 29.7 2.5 3e-07 29.7 1.7 2.3 1 1 1 2 2 2 1 Aflatoxin regulatory protein adh_short PF00106.20 CCF35702.1 - 2.1e-31 109.0 1.2 2.6e-31 108.7 0.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF35702.1 - 4.7e-18 65.8 0.0 6.4e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF35702.1 - 7.8e-14 51.7 0.4 1.1e-13 51.2 0.3 1.1 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.3 CCF35702.1 - 0.0001 22.0 0.6 0.00035 20.3 0.5 1.8 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Bac_luciferase PF00296.15 CCF35702.1 - 0.0041 16.3 0.3 0.0054 15.9 0.2 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase DUF2457 PF10446.4 CCF35703.1 - 0.3 9.7 7.8 0.32 9.6 5.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CENP-I PF07778.6 CCF35703.1 - 0.38 8.8 1.3 0.45 8.6 0.9 1.0 1 0 0 1 1 1 0 Mis6 Mucin PF01456.12 CCF35703.1 - 0.63 9.8 16.2 0.62 9.8 11.2 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein DEADboxA PF12343.3 CCF35703.1 - 0.7 10.1 4.3 0.97 9.7 3.0 1.2 1 0 0 1 1 1 0 Cold shock protein DEAD box A Fungal_trans PF04082.13 CCF35706.1 - 1.7e-23 82.8 0.0 3e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Dioxygenase_C PF00775.16 CCF35707.1 - 1.4e-51 174.3 0.0 1.9e-51 173.9 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.9 CCF35707.1 - 2.3e-14 53.1 0.0 3.5e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.1 CCF35707.1 - 8e-05 22.6 0.0 0.00063 19.7 0.0 2.2 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain YtkA PF13115.1 CCF35707.1 - 0.11 12.9 0.0 0.27 11.6 0.0 1.6 1 0 0 1 1 1 0 YtkA-like OPT PF03169.10 CCF35708.1 - 5e-188 626.4 51.0 5.7e-188 626.2 35.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein CcmD PF04995.9 CCF35708.1 - 1.9 8.2 4.7 0.82 9.4 0.2 2.7 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) ketoacyl-synt PF00109.21 CCF35709.1 - 2e-60 204.3 5.8 7e-60 202.6 0.4 2.2 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 CCF35709.1 - 1.1e-35 122.0 2.7 6.1e-35 119.6 1.3 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 CCF35709.1 - 2.5e-06 26.6 0.2 5.5e-06 25.5 0.1 1.6 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 CCF35709.1 - 0.6 9.5 5.7 0.99 8.8 0.2 3.6 2 2 0 2 2 2 0 Thiolase, C-terminal domain CorA PF01544.13 CCF35713.1 - 3.4e-16 59.1 4.0 4.1e-12 45.7 0.0 2.7 3 0 0 3 3 3 2 CorA-like Mg2+ transporter protein DUF4231 PF14015.1 CCF35713.1 - 0.029 14.3 0.3 0.061 13.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) Peptidase_S49 PF01343.13 CCF35713.1 - 0.11 12.2 0.1 0.26 11.0 0.1 1.5 1 0 0 1 1 1 0 Peptidase family S49 FadA PF09403.5 CCF35713.1 - 1.6 8.7 4.8 7.8 6.5 0.2 2.9 3 0 0 3 3 3 0 Adhesion protein FadA PAPS_reduct PF01507.14 CCF35714.1 - 3.4e-15 56.2 0.0 4.3e-07 29.9 0.0 2.2 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family MCLC PF05934.6 CCF35715.1 - 0.0075 14.6 2.0 0.012 13.9 1.4 1.2 1 0 0 1 1 1 1 Mid-1-related chloride channel (MCLC) Cutinase PF01083.17 CCF35717.1 - 3.6e-50 170.1 1.2 4.5e-50 169.8 0.9 1.1 1 0 0 1 1 1 1 Cutinase Lipase_3 PF01764.20 CCF35717.1 - 0.0001 21.9 0.0 0.00014 21.4 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 CCF35717.1 - 0.00011 21.9 0.3 0.00016 21.4 0.2 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.3 CCF35717.1 - 0.00061 19.2 0.0 0.00096 18.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Thioesterase PF00975.15 CCF35717.1 - 0.0009 19.5 0.1 0.0015 18.8 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Chlorophyllase2 PF12740.2 CCF35717.1 - 0.0043 15.9 0.1 0.0061 15.4 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme PE-PPE PF08237.6 CCF35717.1 - 0.0068 15.8 0.1 0.011 15.1 0.1 1.3 1 0 0 1 1 1 1 PE-PPE domain Abhydrolase_3 PF07859.8 CCF35717.1 - 0.0073 15.9 0.9 0.016 14.7 0.3 1.8 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF35717.1 - 0.013 15.3 0.1 0.017 15.0 0.1 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family VirJ PF06057.6 CCF35717.1 - 0.03 14.0 0.0 0.049 13.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Abhydrolase_2 PF02230.11 CCF35717.1 - 0.078 12.4 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.15 CCF35717.1 - 0.078 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Formyl_trans_N PF00551.14 CCF35718.1 - 1e-35 122.9 0.0 1.4e-35 122.4 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase ACT PF01842.20 CCF35718.1 - 3.7e-08 32.6 0.0 9.8e-08 31.3 0.0 1.8 1 0 0 1 1 1 1 ACT domain ACT_6 PF13740.1 CCF35718.1 - 0.0087 15.7 0.2 0.035 13.8 0.0 2.2 2 1 1 3 3 3 1 ACT domain ABC_membrane PF00664.18 CCF35719.1 - 1.3e-83 280.6 39.0 4e-42 144.5 12.1 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 CCF35719.1 - 5.1e-73 243.8 0.0 3.8e-35 121.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 CCF35719.1 - 6.9e-15 54.8 0.2 4.3e-05 22.8 0.0 4.2 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF35719.1 - 1.7e-13 51.2 0.0 0.069 13.1 0.0 4.3 4 0 0 4 4 4 4 AAA domain ABC_ATPase PF09818.4 CCF35719.1 - 2.8e-10 39.3 0.1 0.0011 17.6 0.0 3.7 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_16 PF13191.1 CCF35719.1 - 2.9e-09 37.1 0.5 0.00035 20.5 0.0 3.1 2 2 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 CCF35719.1 - 3.3e-09 36.1 0.5 0.00018 20.9 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 CCF35719.1 - 3.3e-08 32.8 0.0 0.0023 17.1 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 CCF35719.1 - 3.6e-08 33.6 0.1 0.018 15.1 0.0 4.1 2 2 0 2 2 2 2 AAA domain AAA_25 PF13481.1 CCF35719.1 - 2.8e-07 30.1 0.1 0.032 13.6 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_17 PF13207.1 CCF35719.1 - 2.7e-06 28.2 0.0 0.053 14.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 CCF35719.1 - 1.9e-05 24.5 0.0 0.13 12.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA PF00004.24 CCF35719.1 - 6e-05 23.2 1.1 0.15 12.2 0.3 4.3 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.1 CCF35719.1 - 0.00016 21.3 0.0 2.9 7.4 0.0 4.0 4 0 0 4 4 4 1 AAA domain AAA_5 PF07728.9 CCF35719.1 - 0.00024 20.8 0.1 1.4 8.6 0.0 3.5 4 0 0 4 4 3 2 AAA domain (dynein-related subfamily) AAA_23 PF13476.1 CCF35719.1 - 0.00025 21.4 0.0 0.17 12.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.1 CCF35719.1 - 0.00047 20.0 2.2 1.2 9.1 0.1 4.1 3 2 0 3 3 3 2 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.1 CCF35719.1 - 0.00064 19.6 0.0 2.3 8.1 0.0 3.5 4 0 0 4 4 3 1 AAA domain Zeta_toxin PF06414.7 CCF35719.1 - 0.0018 17.4 0.0 0.33 9.9 0.0 2.9 3 0 0 3 3 3 1 Zeta toxin MobB PF03205.9 CCF35719.1 - 0.0039 16.8 0.0 3.6 7.2 0.0 2.5 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 CCF35719.1 - 0.0066 16.7 0.6 8.3 6.7 0.4 3.0 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 CCF35719.1 - 0.0067 16.5 0.1 1.1 9.5 0.0 2.9 3 0 0 3 3 2 1 RNA helicase MMR_HSR1 PF01926.18 CCF35719.1 - 0.0069 16.3 0.5 16 5.5 0.0 3.5 3 0 0 3 3 3 0 50S ribosome-binding GTPase ATP_bind_1 PF03029.12 CCF35719.1 - 0.0075 15.8 0.1 2.2 7.7 0.0 2.4 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Rad17 PF03215.10 CCF35719.1 - 0.0083 14.8 0.0 0.17 10.5 0.0 2.1 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_19 PF13245.1 CCF35719.1 - 0.02 14.6 0.1 1.9 8.2 0.0 3.1 2 0 0 2 2 2 0 Part of AAA domain MTH865 PF07747.6 CCF35719.1 - 0.03 13.9 0.0 0.16 11.5 0.0 2.3 2 0 0 2 2 1 0 MTH865-like family AAA_28 PF13521.1 CCF35719.1 - 0.032 14.2 0.0 2.4 8.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.16 CCF35719.1 - 0.05 12.7 0.0 1.3 8.1 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI G-alpha PF00503.15 CCF35719.1 - 0.075 11.7 0.0 2.5 6.6 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit AAA_10 PF12846.2 CCF35719.1 - 0.096 12.0 3.3 4.1 6.7 0.1 3.0 3 0 0 3 3 3 0 AAA-like domain APS_kinase PF01583.15 CCF35719.1 - 0.13 11.9 0.0 3.8 7.1 0.0 2.6 2 0 0 2 2 2 0 Adenylylsulphate kinase NB-ARC PF00931.17 CCF35719.1 - 0.16 10.7 0.2 8.3 5.1 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain E1-E2_ATPase PF00122.15 CCF35721.1 - 1.4e-60 204.1 1.0 3.2e-60 203.0 0.7 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 CCF35721.1 - 3e-30 106.2 0.0 3.6e-29 102.7 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.16 CCF35721.1 - 2.5e-24 85.7 8.7 2.5e-24 85.7 6.0 2.7 2 1 1 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.21 CCF35721.1 - 6.1e-16 57.6 2.2 9.1e-16 57.0 0.0 2.5 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Hydrolase_like2 PF13246.1 CCF35721.1 - 1.1e-15 57.3 0.0 2.3e-15 56.2 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 CCF35721.1 - 8.6e-12 45.6 0.0 2.8e-11 43.9 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CCF35721.1 - 5.3e-06 26.1 0.2 1.4e-05 24.7 0.1 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF3621 PF12285.3 CCF35721.1 - 0.34 11.1 0.8 0.72 10.0 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3621) Aminotran_1_2 PF00155.16 CCF35722.1 - 5.1e-69 232.9 0.0 1e-68 231.9 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 CCF35722.1 - 0.0097 15.0 0.0 0.023 13.8 0.0 1.6 2 0 0 2 2 2 1 Beta-eliminating lyase ISN1 PF06437.6 CCF35723.1 - 4.6e-118 394.4 0.0 5e-118 394.3 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase FlbD PF06289.6 CCF35723.1 - 0.092 12.1 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Flagellar protein (FlbD) NIR_SIR PF01077.17 CCF35724.1 - 2.1e-55 186.3 0.0 4.6e-48 162.5 0.0 2.5 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.12 CCF35724.1 - 2.1e-31 107.3 0.0 2.5e-15 55.8 0.0 2.6 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.20 CCF35724.1 - 5.6e-30 104.2 0.0 1.2e-29 103.1 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin POR_N PF01855.14 CCF35724.1 - 1e-08 34.9 0.1 2.6e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg AMP-binding PF00501.23 CCF35725.1 - 2.6e-117 391.7 0.0 7.6e-85 284.7 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.15 CCF35725.1 - 4.3e-67 226.0 0.0 1.3e-35 122.6 0.0 2.4 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.20 CCF35725.1 - 1.5e-23 82.8 0.1 1.4e-10 41.2 0.0 3.6 3 0 0 3 3 3 2 Phosphopantetheine attachment site AMP-binding_C PF13193.1 CCF35725.1 - 1.2e-11 45.3 3.0 7.9e-05 23.5 0.0 3.7 5 0 0 5 5 5 2 AMP-binding enzyme C-terminal domain Transferase PF02458.10 CCF35725.1 - 2.1e-05 23.1 0.0 0.1 11.0 0.0 2.4 2 0 0 2 2 2 2 Transferase family NIR_SIR PF01077.17 CCF35726.1 - 2.7e-29 101.5 0.0 4.6e-29 100.8 0.0 1.4 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain Pyr_redox_2 PF07992.9 CCF35726.1 - 1.4e-19 70.8 0.1 2.4e-19 70.0 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF35726.1 - 1.3e-15 57.5 1.0 3.9e-15 56.0 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Fer2_BFD PF04324.10 CCF35726.1 - 8.3e-15 54.5 2.6 1.2e-10 41.2 2.5 2.8 2 0 0 2 2 2 2 BFD-like [2Fe-2S] binding domain Rieske_2 PF13806.1 CCF35726.1 - 5.8e-14 51.6 0.0 3.1e-06 26.8 0.0 2.7 2 0 0 2 2 2 2 Rieske-like [2Fe-2S] domain Rieske PF00355.21 CCF35726.1 - 1.3e-11 43.9 0.3 1.1e-10 40.9 0.0 2.5 2 1 0 2 2 2 1 Rieske [2Fe-2S] domain NIR_SIR_ferr PF03460.12 CCF35726.1 - 3.1e-08 33.0 0.0 7.1e-08 31.9 0.0 1.7 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain Pyr_redox_3 PF13738.1 CCF35726.1 - 3.7e-05 23.8 0.0 0.0014 18.7 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 CCF35726.1 - 0.061 12.3 0.4 0.14 11.1 0.1 1.7 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase GIDA PF01134.17 CCF35726.1 - 0.12 11.1 0.9 24 3.6 0.0 3.0 2 1 1 3 3 3 0 Glucose inhibited division protein A NAD_binding_9 PF13454.1 CCF35726.1 - 0.21 11.3 0.6 2.6 7.8 0.0 2.7 2 1 1 3 3 3 0 FAD-NAD(P)-binding Fungal_trans_2 PF11951.3 CCF35727.1 - 8.9e-13 47.5 2.3 1.6e-12 46.7 1.6 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain p450 PF00067.17 CCF35728.1 - 4.1e-49 167.3 0.0 5.5e-49 166.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ABC_tran PF00005.22 CCF35729.1 - 2.6e-43 147.6 0.0 1.1e-25 90.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 CCF35729.1 - 8.9e-28 97.4 30.3 1.3e-13 51.0 6.9 3.8 4 0 0 4 4 4 3 ABC transporter transmembrane region SMC_N PF02463.14 CCF35729.1 - 3.2e-13 49.4 0.9 1.1e-05 24.7 0.0 4.1 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF35729.1 - 3.5e-09 37.0 0.0 0.0055 16.6 0.0 4.2 3 1 0 3 3 3 1 AAA domain AAA_16 PF13191.1 CCF35729.1 - 1.9e-06 27.9 1.1 0.077 12.9 0.0 3.1 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 CCF35729.1 - 2.4e-06 26.9 0.6 0.014 14.9 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.1 CCF35729.1 - 6.1e-06 25.7 0.1 0.0085 15.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.1 CCF35729.1 - 1.1e-05 25.8 1.0 0.0024 18.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 CCF35729.1 - 1.5e-05 24.0 0.3 0.11 11.3 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_22 PF13401.1 CCF35729.1 - 2.5e-05 24.4 0.4 0.087 12.9 0.0 3.4 3 1 0 3 3 2 1 AAA domain AAA_10 PF12846.2 CCF35729.1 - 0.00013 21.5 0.3 0.59 9.5 0.1 2.7 2 0 0 2 2 2 2 AAA-like domain DUF258 PF03193.11 CCF35729.1 - 0.00031 19.9 0.0 0.28 10.3 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 NACHT PF05729.7 CCF35729.1 - 0.00055 19.6 1.4 0.56 9.8 0.1 2.9 2 0 0 2 2 2 2 NACHT domain FtsK_SpoIIIE PF01580.13 CCF35729.1 - 0.00086 18.8 0.9 0.49 9.8 0.0 3.0 3 0 0 3 3 3 1 FtsK/SpoIIIE family Miro PF08477.8 CCF35729.1 - 0.00094 19.6 0.1 0.36 11.3 0.0 3.2 3 0 0 3 3 3 1 Miro-like protein DUF87 PF01935.12 CCF35729.1 - 0.0011 18.8 2.6 0.01 15.6 0.2 2.4 2 0 0 2 2 2 1 Domain of unknown function DUF87 MMR_HSR1 PF01926.18 CCF35729.1 - 0.0013 18.6 0.0 0.78 9.7 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase SbcCD_C PF13558.1 CCF35729.1 - 0.0013 18.5 1.2 0.48 10.3 0.0 3.3 4 0 0 4 4 2 1 Putative exonuclease SbcCD, C subunit Arch_ATPase PF01637.13 CCF35729.1 - 0.0026 17.4 0.3 0.058 13.0 0.0 2.7 3 0 0 3 3 2 1 Archaeal ATPase AAA_19 PF13245.1 CCF35729.1 - 0.0063 16.2 3.4 2.7 7.8 0.1 3.2 3 0 0 3 3 2 2 Part of AAA domain AAA PF00004.24 CCF35729.1 - 0.0091 16.2 0.2 7.1 6.8 0.0 3.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.18 CCF35729.1 - 0.01 15.6 0.3 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 Dynamin family cobW PF02492.14 CCF35729.1 - 0.015 14.7 1.9 0.096 12.1 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 CCF35729.1 - 0.017 15.4 0.1 8.9 6.6 0.0 3.4 4 0 0 4 4 3 0 AAA domain Zeta_toxin PF06414.7 CCF35729.1 - 0.051 12.6 0.3 4.9 6.2 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_17 PF13207.1 CCF35729.1 - 0.055 14.2 0.0 9.5 7.0 0.0 2.8 2 0 0 2 2 2 0 AAA domain UPF0079 PF02367.12 CCF35729.1 - 0.056 13.0 0.0 0.72 9.4 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Pox_A32 PF04665.7 CCF35729.1 - 0.075 12.3 0.0 12 5.1 0.0 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_30 PF13604.1 CCF35729.1 - 0.079 12.5 0.7 36 3.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.1 CCF35729.1 - 0.092 12.6 0.0 16 5.3 0.0 2.8 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.4 CCF35729.1 - 0.11 11.4 1.0 4.2 6.2 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) MobB PF03205.9 CCF35729.1 - 0.27 10.9 0.5 26 4.4 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_ATPase PF09818.4 CCF35729.1 - 0.4 9.1 0.8 1.4 7.4 0.1 2.0 2 0 0 2 2 2 0 Predicted ATPase of the ABC class PduV-EutP PF10662.4 CCF35729.1 - 0.64 9.4 1.8 2.9 7.3 0.1 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NOA36 PF06524.7 CCF35729.1 - 1.9 7.6 2.9 3.2 6.9 2.0 1.3 1 0 0 1 1 1 0 NOA36 protein Sigma70_ner PF04546.8 CCF35729.1 - 5.2 6.6 6.1 0.93 9.0 0.7 2.0 2 0 0 2 2 2 0 Sigma-70, non-essential region Fungal_trans PF04082.13 CCF35730.1 - 0.01 14.7 0.0 0.018 13.8 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain DUF2697 PF10906.3 CCF35731.1 - 0.0071 16.3 0.0 0.016 15.1 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2697) Cellulase PF00150.13 CCF35732.1 - 2e-15 56.7 0.0 2.7e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.13 CCF35732.1 - 1e-12 47.4 13.3 2.1e-12 46.4 9.2 1.6 1 0 0 1 1 1 1 Fungal cellulose binding domain DUF2217 PF10265.4 CCF35732.1 - 0.19 10.4 2.2 0.21 10.3 1.5 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Macoilin PF09726.4 CCF35732.1 - 0.33 9.1 2.9 0.4 8.9 2.0 1.1 1 0 0 1 1 1 0 Transmembrane protein Kei1 PF08552.6 CCF35732.1 - 0.97 9.0 3.2 1.4 8.5 2.2 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 PLAC8 PF04749.12 CCF35733.1 - 3.2e-24 85.5 15.5 4e-24 85.1 10.8 1.1 1 0 0 1 1 1 1 PLAC8 family Acetyltransf_1 PF00583.19 CCF35734.1 - 4.7e-15 55.3 0.0 7.3e-15 54.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF35734.1 - 1.7e-08 34.5 0.0 2.7e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CCF35734.1 - 2.7e-08 33.9 0.0 3.8e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF35734.1 - 0.00017 21.2 0.0 0.00033 20.3 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.1 CCF35734.1 - 0.00037 20.6 0.0 0.00052 20.1 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 CCF35734.1 - 0.0012 18.8 0.0 0.0019 18.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 CCF35734.1 - 0.0038 17.1 0.0 0.006 16.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Sugar_tr PF00083.19 CCF35735.1 - 1.3e-20 73.4 27.0 8.4e-14 50.9 5.7 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter DUF3808 PF10300.4 CCF35736.1 - 9.4e-128 426.7 0.0 1.1e-127 426.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_19 PF14559.1 CCF35736.1 - 0.14 12.4 8.2 1.5 9.1 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.9 CCF35736.1 - 0.36 11.3 0.0 0.36 11.3 0.0 4.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.1 CCF35736.1 - 0.44 10.2 7.3 0.55 9.9 0.8 3.6 5 0 0 5 5 5 0 TPR repeat TPR_10 PF13374.1 CCF35736.1 - 9.2 6.3 7.9 0.78 9.7 0.1 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 CCF35736.1 - 9.7 7.1 15.3 4.2 8.2 0.0 6.1 6 1 0 6 6 6 0 Tetratricopeptide repeat Ras PF00071.17 CCF35739.1 - 1.3e-65 219.6 0.5 1.5e-65 219.4 0.3 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF35739.1 - 1.2e-21 77.4 0.0 1.7e-21 76.9 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CCF35739.1 - 2.6e-16 59.3 0.1 3.1e-16 59.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CCF35739.1 - 2.1e-05 23.7 0.1 2.7e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 CCF35739.1 - 2.9e-05 23.5 0.1 6.2e-05 22.5 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CCF35739.1 - 7.2e-05 22.7 0.0 0.00013 21.8 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 CCF35739.1 - 0.00039 19.6 0.0 0.00056 19.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.24 CCF35739.1 - 0.00046 20.3 0.1 0.095 12.9 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CCF35739.1 - 0.0013 18.8 0.0 0.0025 17.9 0.0 1.6 1 1 1 2 2 2 1 AAA domain FeoB_N PF02421.13 CCF35739.1 - 0.0031 16.8 0.0 0.021 14.1 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B DUF258 PF03193.11 CCF35739.1 - 0.0094 15.1 0.0 0.025 13.7 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 CCF35739.1 - 0.016 15.1 0.1 0.064 13.2 0.0 1.9 2 1 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.1 CCF35739.1 - 0.022 14.6 0.2 0.072 12.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 CCF35739.1 - 0.039 13.4 0.0 0.11 12.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.9 CCF35739.1 - 0.067 12.9 0.0 0.098 12.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Septin PF00735.13 CCF35739.1 - 0.072 12.0 0.0 0.2 10.6 0.0 1.7 2 0 0 2 2 2 0 Septin ABC_tran PF00005.22 CCF35739.1 - 0.079 13.2 0.1 0.13 12.5 0.0 1.6 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.4 CCF35739.1 - 0.097 12.1 0.0 0.94 8.9 0.0 2.2 1 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Rad51 PF08423.6 CCF35741.1 - 4.1e-21 75.0 0.0 5.9e-21 74.5 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 CCF35741.1 - 2.4e-10 40.1 0.0 4.4e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 CCF35741.1 - 1.3e-06 27.7 0.0 2.6e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 KaiC RecA PF00154.16 CCF35741.1 - 2.5e-06 26.7 0.0 0.00037 19.6 0.0 2.1 2 0 0 2 2 2 2 recA bacterial DNA recombination protein AAA_22 PF13401.1 CCF35741.1 - 0.012 15.7 0.1 0.052 13.6 0.0 2.1 2 1 0 2 2 2 0 AAA domain PAXNEB PF05625.6 CCF35741.1 - 0.039 12.8 0.1 0.061 12.1 0.0 1.2 1 0 0 1 1 1 0 PAXNEB protein Macoilin PF09726.4 CCF35742.1 - 4 5.5 6.6 4.3 5.4 4.5 1.0 1 0 0 1 1 1 0 Transmembrane protein CHZ PF09649.5 CCF35743.1 - 0.0018 17.4 0.3 0.0034 16.5 0.2 1.4 1 0 0 1 1 1 1 Histone chaperone domain CHZ DUF2382 PF09557.5 CCF35743.1 - 0.085 12.7 0.7 0.11 12.4 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2382) AA_permease_2 PF13520.1 CCF35744.1 - 6.5e-81 272.0 35.6 8.3e-81 271.6 24.7 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF35744.1 - 1.3e-21 76.4 30.1 1.7e-21 76.1 20.9 1.1 1 0 0 1 1 1 1 Amino acid permease PHD PF00628.24 CCF35745.1 - 1.4e-08 34.2 8.9 2.8e-08 33.3 6.2 1.5 1 0 0 1 1 1 1 PHD-finger SET PF00856.23 CCF35745.1 - 6.5e-05 23.2 0.0 6.5e-05 23.2 0.0 2.6 3 1 0 3 3 3 1 SET domain Glycos_transf_4 PF00953.16 CCF35746.1 - 1.4e-27 96.4 9.7 1.4e-27 96.4 6.7 2.1 3 0 0 3 3 3 1 Glycosyl transferase family 4 Methyltransf_8 PF05148.10 CCF35747.1 - 4.3e-21 75.5 0.1 6.5e-21 74.9 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase Draxin PF15550.1 CCF35747.1 - 0.75 9.3 17.4 0.96 9.0 12.0 1.1 1 0 0 1 1 1 0 Draxin DUF1675 PF07897.6 CCF35747.1 - 2.8 7.7 20.7 3.8 7.3 14.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) CDK2AP PF09806.4 CCF35747.1 - 4.7 7.4 12.4 0.24 11.5 3.4 2.0 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein Fungal_trans_2 PF11951.3 CCF35748.1 - 2.6e-19 69.1 0.4 2.6e-11 42.7 0.1 3.1 3 0 0 3 3 3 3 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF35748.1 - 4.8e-09 35.9 11.2 7.8e-09 35.3 7.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF35748.1 - 6.6e-05 21.9 1.1 0.00084 18.2 0.7 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Proteasome PF00227.21 CCF35749.1 - 1e-56 191.2 0.1 1.3e-56 190.9 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 CCF35749.1 - 1e-13 50.2 0.0 2.2e-13 49.2 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF3137 PF11335.3 CCF35749.1 - 0.0027 17.3 0.2 0.089 12.4 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3137) Spc97_Spc98 PF04130.8 CCF35750.1 - 1.4e-131 439.5 0.5 1.9e-131 439.0 0.4 1.2 1 0 0 1 1 1 1 Spc97 / Spc98 family YqeY PF09424.5 CCF35751.1 - 1.6e-17 63.7 2.4 1.8e-17 63.5 1.7 1.1 1 0 0 1 1 1 1 Yqey-like protein F-box-like PF12937.2 CCF35752.1 - 1.3e-08 34.4 0.1 2.3e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF35752.1 - 1.7e-07 30.7 0.0 5e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 F-box domain UIM PF02809.15 CCF35752.1 - 1.1 9.0 23.6 0.74 9.5 2.1 4.7 4 0 0 4 4 4 0 Ubiquitin interaction motif Asp PF00026.18 CCF35754.1 - 1.2e-09 37.8 1.0 5.1e-09 35.7 0.7 1.9 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Adeno_E3_CR2 PF02439.10 CCF35754.1 - 0.14 11.7 1.0 0.28 10.7 0.7 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Flavodoxin_1 PF00258.20 CCF35755.1 - 1.9e-30 105.7 0.0 3.1e-30 105.0 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.15 CCF35755.1 - 4.3e-23 81.8 0.0 1.6e-20 73.4 0.0 2.7 2 1 0 2 2 2 2 FAD binding domain NAD_binding_1 PF00175.16 CCF35755.1 - 8.4e-11 42.4 0.0 3.9e-10 40.2 0.0 2.1 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_3 PF12641.2 CCF35755.1 - 0.0085 15.5 0.0 0.02 14.3 0.0 1.6 2 0 0 2 2 2 1 Flavodoxin domain Flavodoxin_5 PF12724.2 CCF35755.1 - 0.029 14.3 0.0 0.071 13.1 0.0 1.7 1 0 0 1 1 1 0 Flavodoxin domain Flavodoxin_NdrI PF07972.6 CCF35755.1 - 0.2 11.5 0.0 0.4 10.6 0.0 1.5 1 0 0 1 1 1 0 NrdI Flavodoxin like EHN PF06441.7 CCF35757.1 - 7.2e-28 96.7 0.0 1.2e-27 95.9 0.0 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_6 PF12697.2 CCF35757.1 - 9.1e-06 25.7 0.0 2.3e-05 24.3 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF35757.1 - 0.00047 19.7 0.0 0.002 17.7 0.0 2.0 2 1 0 2 2 2 1 alpha/beta hydrolase fold HET PF06985.6 CCF35758.1 - 2.5e-21 76.2 0.2 4.9e-21 75.3 0.1 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Aminotran_4 PF01063.14 CCF35759.1 - 1.2e-13 51.1 0.0 3.7e-13 49.4 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class IV MFS_1 PF07690.11 CCF35760.1 - 9.3e-25 87.0 37.9 2.1e-24 85.8 23.7 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF35760.1 - 9.5e-13 47.5 6.8 9.5e-13 47.5 4.7 2.8 3 1 1 4 4 4 1 Sugar (and other) transporter TRI12 PF06609.8 CCF35760.1 - 4.1e-06 25.2 10.2 6.2e-06 24.7 7.1 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) NfeD PF01957.13 CCF35760.1 - 0.041 14.0 0.7 0.041 14.0 0.5 4.5 3 1 1 5 5 5 0 NfeD-like C-terminal, partner-binding YtpI PF14007.1 CCF35760.1 - 1.8 8.5 6.1 7.7 6.5 0.1 2.8 2 0 0 2 2 2 0 YtpI-like protein DUF3784 PF12650.2 CCF35760.1 - 4.8 7.1 8.7 9.8 6.1 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF3784) p450 PF00067.17 CCF35762.1 - 2.7e-24 85.5 0.0 3e-24 85.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PLDc PF00614.17 CCF35763.1 - 1.3e-16 59.8 1.2 4.7e-08 32.5 0.2 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.1 CCF35763.1 - 1.2e-12 47.7 0.0 6.1e-08 32.4 0.0 2.7 2 0 0 2 2 2 2 PLD-like domain PX PF00787.19 CCF35763.1 - 2.4e-07 30.5 0.0 3.1e-06 26.9 0.0 2.9 3 1 0 3 3 3 1 PX domain Mcp5_PH PF12814.2 CCF35765.1 - 3.4e-45 152.9 0.0 6.4e-45 152.0 0.0 1.4 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology Peptidase_M24 PF00557.19 CCF35766.1 - 6.8e-49 166.2 0.1 8.8e-49 165.8 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 CCF35766.1 - 4e-27 94.2 0.0 1.2e-26 92.6 0.0 1.7 2 0 0 2 2 2 1 Aminopeptidase P, N-terminal domain Peptidase_C12 PF01088.16 CCF35767.1 - 7.1e-55 185.4 0.0 9e-55 185.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 NicO PF03824.11 CCF35768.1 - 4.7e-65 219.7 7.5 7.3e-65 219.0 5.2 1.2 1 0 0 1 1 1 1 High-affinity nickel-transport protein DAO PF01266.19 CCF35769.1 - 0.00029 19.8 0.1 0.00037 19.5 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 CCF35770.1 - 1.8e-13 50.9 0.0 2.3e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF35770.1 - 1.1e-10 41.3 0.0 2.3e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.14 CCF35770.1 - 3.8e-10 38.5 0.1 1.6e-09 36.5 0.1 1.7 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.1 CCF35770.1 - 2.2e-07 30.7 0.1 1.2e-05 25.1 0.1 2.1 1 1 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 CCF35770.1 - 0.0084 16.0 0.0 0.012 15.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF35770.1 - 0.024 13.5 0.0 0.033 13.0 0.0 1.3 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.9 CCF35770.1 - 0.14 10.5 0.0 0.22 9.9 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Polysacc_deac_1 PF01522.16 CCF35771.1 - 1.6e-14 53.5 0.0 3.1e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase CIA30 PF08547.7 CCF35771.1 - 6.3e-06 26.1 0.0 0.0056 16.5 0.0 3.1 3 0 0 3 3 3 1 Complex I intermediate-associated protein 30 (CIA30) Endotoxin_C PF03944.9 CCF35771.1 - 0.012 15.7 0.0 2.4 8.2 0.0 2.7 2 0 0 2 2 2 0 delta endotoxin ThuA PF06283.6 CCF35771.1 - 0.074 12.7 0.2 0.44 10.2 0.0 2.0 2 0 0 2 2 2 0 Trehalose utilisation GMC_oxred_N PF00732.14 CCF35772.1 - 5.2e-52 176.8 0.0 6.9e-52 176.4 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF35772.1 - 3.3e-26 92.2 0.3 5.7e-26 91.5 0.2 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 CCF35772.1 - 3.6e-05 22.7 0.1 0.019 13.8 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 CCF35772.1 - 0.00011 21.2 0.3 0.031 13.1 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF35772.1 - 0.0038 17.2 0.1 0.011 15.7 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF35772.1 - 0.0045 17.0 0.0 1.7 8.6 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CCF35772.1 - 0.076 12.8 0.0 1.6 8.5 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF35772.1 - 0.14 11.2 0.1 0.14 11.2 0.1 1.8 2 0 0 2 2 2 0 Thi4 family Lipase_GDSL PF00657.17 CCF35773.1 - 1e-14 54.9 0.0 2.4e-14 53.7 0.0 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.1 CCF35773.1 - 2e-12 47.5 0.8 2.9e-12 47.0 0.6 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family MucB_RseB PF03888.9 CCF35773.1 - 0.16 10.9 0.0 0.22 10.5 0.0 1.1 1 0 0 1 1 1 0 MucB/RseB family hEGF PF12661.2 CCF35774.1 - 0.33 11.1 4.3 2.5 8.3 0.6 2.8 2 0 0 2 2 2 0 Human growth factor-like EGF Peptidase_M13_N PF05649.8 CCF35776.1 - 6.2e-60 203.2 0.0 1.2e-59 202.3 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M13 Peptidase_M13 PF01431.16 CCF35776.1 - 5.5e-56 189.0 1.2 9.8e-56 188.1 0.8 1.4 1 0 0 1 1 1 1 Peptidase family M13 PilJ PF13675.1 CCF35776.1 - 0.016 15.5 0.1 0.039 14.2 0.1 1.6 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term Pkinase PF00069.20 CCF35778.1 - 1.4e-71 240.7 0.0 1.9e-71 240.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF35778.1 - 3.2e-31 108.3 0.0 4.7e-31 107.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 CCF35778.1 - 1.4e-12 47.8 2.2 1.4e-12 47.8 1.5 2.5 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.1 CCF35778.1 - 1e-09 37.7 0.0 2e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like C2 PF00168.25 CCF35778.1 - 3.1e-05 23.7 0.0 0.00015 21.5 0.0 2.1 1 1 0 1 1 1 1 C2 domain Kdo PF06293.9 CCF35778.1 - 0.018 14.0 0.0 0.033 13.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CCF35778.1 - 0.04 13.6 0.0 0.083 12.6 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 CCF35778.1 - 0.084 12.2 0.0 0.22 10.8 0.0 1.7 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Choline_kinase PF01633.15 CCF35778.1 - 0.087 12.3 0.2 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase ATP_sub_h PF10775.4 CCF35779.1 - 1.8e-26 91.6 0.6 2.7e-26 91.0 0.4 1.3 1 0 0 1 1 1 1 ATP synthase complex subunit h ATP-synt_F6 PF05511.6 CCF35779.1 - 0.015 15.1 0.1 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ATP synthase coupling factor 6 DOMON PF03351.12 CCF35780.1 - 5.2e-08 32.8 0.5 1.1e-07 31.8 0.3 1.5 1 0 0 1 1 1 1 DOMON domain DUF2427 PF10348.4 CCF35780.1 - 1.1e-05 24.9 7.7 1.1e-05 24.9 5.4 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF2427) Serglycin PF04360.7 CCF35780.1 - 5.6 6.6 14.0 0.4 10.4 6.0 1.9 2 0 0 2 2 2 0 Serglycin DUF4401 PF14351.1 CCF35781.1 - 0.12 11.3 0.0 0.13 11.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4401) HeLo PF14479.1 CCF35785.1 - 0.0025 17.5 0.3 0.004 16.9 0.1 1.5 1 1 0 1 1 1 1 Prion-inhibition and propagation SRR1 PF07985.7 CCF35786.1 - 0.0099 15.7 0.0 0.02 14.7 0.0 1.5 1 1 0 1 1 1 1 SRR1 LZ_Tnp_IS66 PF13007.2 CCF35787.1 - 0.26 11.9 7.4 1.6 9.4 2.1 2.1 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain Lactamase_B PF00753.22 CCF35789.1 - 4.7e-14 52.4 0.2 1e-13 51.4 0.1 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CCF35789.1 - 1.7e-05 24.4 0.6 7.6e-05 22.3 0.4 1.9 1 1 0 2 2 2 1 Beta-lactamase superfamily domain Chromo PF00385.19 CCF35790.1 - 4.2e-06 26.3 0.5 1e-05 25.0 0.1 1.8 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain SF3b1 PF08920.5 CCF35790.1 - 0.053 13.5 1.4 0.14 12.1 1.0 1.7 1 0 0 1 1 1 0 Splicing factor 3B subunit 1 Methyltransf_16 PF10294.4 CCF35791.1 - 3e-15 56.0 0.0 4.9e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 CCF35791.1 - 6.3e-05 23.5 0.0 0.00017 22.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF35791.1 - 0.0023 18.3 0.0 0.0048 17.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF35791.1 - 0.086 12.2 0.0 0.3 10.4 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase small domain AhpC-TSA PF00578.16 CCF35792.1 - 1.7e-38 131.0 0.0 2.3e-38 130.6 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 CCF35792.1 - 9.7e-13 47.8 0.0 1.3e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 CCF35792.1 - 5.3e-12 45.1 0.0 9.1e-12 44.4 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin PhzC-PhzF PF02567.11 CCF35794.1 - 3.7e-13 49.3 0.0 4.7e-13 48.9 0.0 1.3 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein RVT_1 PF00078.22 CCF35795.1 - 1.4e-40 138.9 0.0 2e-40 138.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.19 CCF35795.1 - 3.6e-16 59.7 0.0 7.3e-16 58.7 0.0 1.5 1 0 0 1 1 1 1 RNase H Not3 PF04065.10 CCF35798.1 - 1.7e-100 335.1 27.2 1.9e-100 334.9 18.8 1.0 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component Cep57_MT_bd PF06657.8 CCF35798.1 - 0.0063 16.4 10.0 0.032 14.1 0.9 2.8 2 0 0 2 2 2 1 Centrosome microtubule-binding domain of Cep57 DUF1192 PF06698.6 CCF35798.1 - 0.0067 16.2 3.8 0.0067 16.2 2.6 3.4 3 1 1 4 4 4 1 Protein of unknown function (DUF1192) Snapin_Pallidin PF14712.1 CCF35798.1 - 0.038 14.2 0.8 0.038 14.2 0.6 2.5 2 1 1 3 3 3 0 Snapin/Pallidin HUN PF08729.5 CCF35798.1 - 0.048 13.5 2.5 0.12 12.2 1.7 1.7 1 0 0 1 1 1 0 HPC2 and ubinuclein domain DASH_Dad2 PF08654.5 CCF35798.1 - 0.06 13.3 6.4 0.091 12.7 0.3 2.7 2 0 0 2 2 2 0 DASH complex subunit Dad2 Sec5 PF15469.1 CCF35798.1 - 0.16 11.7 13.2 0.11 12.2 2.2 2.3 2 0 0 2 2 2 0 Exocyst complex component Sec5 SNARE PF05739.14 CCF35798.1 - 0.28 10.9 6.8 0.049 13.3 1.3 2.3 2 0 0 2 2 2 0 SNARE domain WXG100 PF06013.7 CCF35798.1 - 0.28 11.2 8.2 0.077 13.0 1.6 2.8 2 1 1 3 3 3 0 Proteins of 100 residues with WXG DehI PF10778.4 CCF35798.1 - 0.43 10.0 7.3 0.033 13.7 1.3 1.9 2 1 0 2 2 2 0 Halocarboxylic acid dehydrogenase DehI Syntaxin-6_N PF09177.6 CCF35798.1 - 0.47 10.8 15.8 0.49 10.8 3.1 3.2 1 1 2 3 3 3 0 Syntaxin 6, N-terminal V_ATPase_I PF01496.14 CCF35798.1 - 0.81 7.4 12.0 1 7.1 8.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Syntaxin PF00804.20 CCF35798.1 - 1.1 9.4 20.1 3.6 7.8 2.5 2.6 1 1 0 2 2 2 0 Syntaxin Nnf1 PF03980.9 CCF35798.1 - 1.4 8.9 15.5 0.23 11.4 3.1 2.9 1 1 1 2 2 2 0 Nnf1 Poty_PP PF08440.5 CCF35798.1 - 2.8 6.9 8.8 0.45 9.5 2.1 2.0 1 1 1 2 2 2 0 Potyviridae polyprotein DUF3810 PF12725.2 CCF35798.1 - 3 6.6 10.3 0.27 10.0 0.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) Vps51 PF08700.6 CCF35798.1 - 3.2 7.6 8.5 4.7 7.1 1.0 2.6 2 0 0 2 2 2 0 Vps51/Vps67 Mnd1 PF03962.10 CCF35798.1 - 3.4 7.3 24.1 0.58 9.7 3.8 2.6 1 1 1 2 2 2 0 Mnd1 family Syntaxin_2 PF14523.1 CCF35798.1 - 3.7 7.6 13.6 0.78 9.8 4.3 2.6 1 1 2 3 3 3 0 Syntaxin-like protein DUF1917 PF08939.5 CCF35798.1 - 6.6 6.3 13.0 5.8 6.5 1.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1917) YlqD PF11068.3 CCF35798.1 - 6.8 6.7 23.6 0.63 10.0 4.0 2.6 2 1 0 2 2 2 0 YlqD protein NPV_P10 PF05531.7 CCF35798.1 - 6.8 7.0 7.7 5.3 7.3 0.5 3.4 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein CorA PF01544.13 CCF35798.1 - 7.1 5.5 7.8 0.88 8.5 1.6 2.0 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein EMP24_GP25L PF01105.19 CCF35798.1 - 8.1 6.1 10.4 6.6 6.4 1.8 2.4 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Tyr_Deacylase PF02580.11 CCF35799.1 - 9.4e-40 135.9 0.0 1.2e-39 135.6 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Pro_isomerase PF00160.16 CCF35800.1 - 2.8e-34 118.5 0.0 4.3e-34 117.9 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_11 PF13414.1 CCF35800.1 - 3.2e-08 33.1 7.6 6.8e-05 22.4 0.5 2.3 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 CCF35800.1 - 2.3e-06 27.0 1.4 0.00041 20.0 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 CCF35800.1 - 0.00011 21.6 1.4 0.002 17.6 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 CCF35800.1 - 0.037 13.8 0.1 0.098 12.5 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Abhydrolase_6 PF12697.2 CCF35802.1 - 3.3e-19 69.6 2.2 5.1e-19 69.0 1.5 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF35802.1 - 3e-10 40.0 0.1 1.3e-09 37.9 0.1 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF35802.1 - 0.0032 17.0 0.1 0.0048 16.4 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF35802.1 - 0.058 12.6 0.0 1 8.5 0.0 2.5 3 0 0 3 3 3 0 Prolyl oligopeptidase family TAF4 PF05236.9 CCF35803.1 - 0.003 16.8 22.3 0.026 13.8 11.3 3.9 3 1 0 3 3 3 1 Transcription initiation factor TFIID component TAF4 family Suf PF05843.9 CCF35803.1 - 4.2 7.0 7.6 8.6 5.9 5.3 1.5 1 1 0 1 1 1 0 Suppressor of forked protein (Suf) TTL PF03133.10 CCF35804.1 - 1.3e-52 178.6 0.0 2e-52 177.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.12 CCF35804.1 - 9.2e-45 152.3 0.0 1.3e-44 151.8 0.0 1.2 1 0 0 1 1 1 1 Survival protein SurE ATPgrasp_YheCD PF14398.1 CCF35804.1 - 0.00046 19.0 0.0 0.0014 17.5 0.0 1.7 2 0 0 2 2 2 1 YheC/D like ATP-grasp ATP-grasp_4 PF13535.1 CCF35804.1 - 0.012 15.3 0.1 0.25 11.0 0.0 2.3 2 0 0 2 2 2 0 ATP-grasp domain Nro1 PF12753.2 CCF35804.1 - 0.16 10.9 1.1 0.28 10.1 0.7 1.4 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 E1-E2_ATPase PF00122.15 CCF35805.1 - 2.1e-55 187.2 0.8 2.1e-55 187.2 0.6 2.6 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CCF35805.1 - 2e-42 144.7 7.9 2e-42 144.7 5.5 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CCF35805.1 - 1.5e-28 100.6 0.0 8.1e-28 98.2 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF35805.1 - 7.6e-20 70.6 0.0 1.5e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 CCF35805.1 - 2.4e-17 63.7 0.0 4.2e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CCF35805.1 - 3.3e-06 26.8 0.8 7.9e-06 25.6 0.3 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 CCF35805.1 - 1.6e-05 24.2 0.0 6.1e-05 22.3 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus DUF2207 PF09972.4 CCF35805.1 - 0.14 10.7 0.8 0.62 8.5 0.1 2.3 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) Pyr_redox_3 PF13738.1 CCF35806.1 - 1.5e-23 83.8 0.1 4.1e-22 79.2 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 CCF35806.1 - 4.5e-17 61.4 0.0 5.8e-16 57.7 0.0 2.1 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.1 CCF35806.1 - 7.3e-17 61.2 0.2 4e-13 48.9 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 CCF35806.1 - 8.6e-16 58.4 0.0 1.3e-12 47.9 0.0 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 CCF35806.1 - 1.3e-09 37.5 0.1 0.00015 20.9 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 CCF35806.1 - 1.5e-06 27.3 0.3 0.00063 18.7 0.0 2.8 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 CCF35806.1 - 6.9e-06 25.9 1.4 0.12 12.1 0.3 3.1 2 1 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox PF00070.22 CCF35806.1 - 2.2e-05 24.7 0.1 0.35 11.2 0.0 3.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF35806.1 - 0.0016 17.4 0.2 0.11 11.4 0.0 3.0 2 1 1 3 3 3 1 Lycopene cyclase protein GIDA PF01134.17 CCF35806.1 - 0.0052 15.7 0.2 9.8 4.9 0.0 3.1 3 0 0 3 3 3 2 Glucose inhibited division protein A Thi4 PF01946.12 CCF35806.1 - 0.0056 15.7 0.1 0.36 9.8 0.0 2.6 3 0 0 3 3 3 1 Thi4 family FAD_binding_2 PF00890.19 CCF35806.1 - 0.011 14.6 1.2 0.11 11.3 0.0 2.2 1 1 0 2 2 2 0 FAD binding domain GHL12 PF14882.1 CCF35806.1 - 0.35 10.9 1.7 6.6 6.9 0.1 2.5 2 0 0 2 2 2 0 Hypothetical glycosyl hydrolase 12 TPR_11 PF13414.1 CCF35807.1 - 8.2e-14 51.0 0.5 1e-08 34.6 0.1 2.4 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 CCF35807.1 - 1.4e-10 40.2 5.9 1.4e-05 24.6 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 CCF35807.1 - 9e-08 31.4 2.7 0.026 14.1 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 CCF35807.1 - 7.4e-06 25.8 0.7 0.0008 19.2 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 CCF35807.1 - 1.2e-05 24.7 0.2 0.01 15.5 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 CCF35807.1 - 7.4e-05 23.0 0.8 0.001 19.3 0.5 2.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 CCF35807.1 - 0.00066 20.2 7.7 0.0013 19.3 0.9 3.0 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 CCF35807.1 - 0.004 17.6 8.8 0.01 16.3 0.2 3.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_9 PF13371.1 CCF35807.1 - 0.024 14.4 4.0 0.27 11.1 0.2 3.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.1 CCF35807.1 - 0.12 12.3 2.4 0.79 9.7 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.9 CCF35807.1 - 0.21 12.1 0.6 0.21 12.1 0.4 3.2 3 1 0 3 3 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 CCF35807.1 - 0.23 11.9 2.0 0.91 10.1 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Josephin PF02099.12 CCF35808.1 - 0.11 12.0 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Josephin UBA_4 PF14555.1 CCF35809.1 - 0.0026 17.2 0.0 0.0042 16.5 0.0 1.3 1 0 0 1 1 1 1 UBA-like domain LysM PF01476.15 CCF35809.1 - 0.0087 15.9 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 1 LysM domain CPSF_A PF03178.10 CCF35810.1 - 1.8e-101 339.4 0.0 6.9e-101 337.5 0.0 2.0 3 0 0 3 3 3 1 CPSF A subunit region MMS1_N PF10433.4 CCF35810.1 - 2.2e-68 230.6 0.0 3.6e-68 229.9 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term PQ-loop PF04193.9 CCF35812.1 - 2.5e-08 33.3 2.8 1.5e-07 30.8 1.9 2.0 1 1 0 1 1 1 1 PQ loop repeat Exo_endo_phos PF03372.18 CCF35813.1 - 2.2e-12 47.4 0.2 2.6e-12 47.1 0.1 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 CCF35813.1 - 0.0013 18.3 0.0 0.0031 17.1 0.0 1.7 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase RTA1 PF04479.8 CCF35814.1 - 6.6e-52 176.2 7.9 8.8e-52 175.8 5.5 1.1 1 0 0 1 1 1 1 RTA1 like protein zf-DHHC PF01529.15 CCF35814.1 - 3.6 6.9 9.6 11 5.3 1.5 2.8 1 1 0 2 2 2 0 DHHC palmitoyltransferase Sugar_tr PF00083.19 CCF35816.1 - 1.9e-92 310.2 20.9 2.1e-92 310.0 14.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF35816.1 - 1.8e-13 49.9 37.1 2.3e-09 36.4 9.6 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily DUF1228 PF06779.9 CCF35816.1 - 0.00069 19.5 1.8 0.12 12.3 0.2 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1228) Lig_chan PF00060.21 CCF35816.1 - 0.97 9.1 5.3 1.1 8.9 1.5 2.3 2 0 0 2 2 2 0 Ligand-gated ion channel MscL PF01741.13 CCF35817.1 - 0.1 12.7 0.2 0.14 12.3 0.1 1.2 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL SUR7 PF06687.7 CCF35818.1 - 7.5e-30 104.0 0.8 8.7e-30 103.8 0.5 1.0 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.3 CCF35818.1 - 1.6e-06 28.1 5.8 1.6e-06 28.1 4.0 1.8 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SCAMP PF04144.8 CCF35818.1 - 0.11 12.3 4.3 2.2 8.1 0.3 2.5 3 0 0 3 3 3 0 SCAMP family DUF788 PF05620.6 CCF35818.1 - 0.44 10.3 2.6 0.93 9.3 1.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF788) DUF4231 PF14015.1 CCF35818.1 - 0.46 10.4 8.4 0.33 10.9 0.5 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF4231) DUF2749 PF10907.3 CCF35818.1 - 0.54 10.1 0.1 0.54 10.1 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2749) HemY_N PF07219.8 CCF35818.1 - 6.8 6.3 8.5 1.7 8.2 0.1 3.0 3 0 0 3 3 3 0 HemY protein N-terminus ABC_tran PF00005.22 CCF35819.1 - 5e-20 72.1 0.0 8.3e-20 71.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 CCF35819.1 - 1.8e-06 28.1 0.1 0.024 14.6 0.0 2.4 1 1 0 2 2 2 2 AAA domain AAA_16 PF13191.1 CCF35819.1 - 0.0021 18.0 0.0 0.0066 16.4 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 CCF35819.1 - 0.0036 17.1 0.0 0.007 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 CCF35819.1 - 0.0094 15.4 0.1 0.025 14.0 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain UPF0079 PF02367.12 CCF35819.1 - 0.0095 15.5 0.2 0.019 14.5 0.1 1.4 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 T2SE PF00437.15 CCF35819.1 - 0.022 13.6 0.0 0.031 13.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_25 PF13481.1 CCF35819.1 - 0.049 13.0 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 CCF35819.1 - 0.056 12.6 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 SMC_N PF02463.14 CCF35819.1 - 0.075 12.2 0.0 0.53 9.4 0.0 1.8 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain Dynamin_N PF00350.18 CCF35819.1 - 0.084 12.6 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Dynamin family Guanylate_kin PF00625.16 CCF35819.1 - 0.2 11.0 0.0 0.34 10.3 0.0 1.3 1 0 0 1 1 1 0 Guanylate kinase AAA_PrkA PF08298.6 CCF35819.1 - 0.31 9.6 0.1 0.59 8.7 0.1 1.4 1 1 0 1 1 1 0 PrkA AAA domain EXS PF03124.9 CCF35820.1 - 3.5e-97 325.5 25.5 4.3e-97 325.2 17.7 1.1 1 0 0 1 1 1 1 EXS family SPX PF03105.14 CCF35820.1 - 1.1e-58 199.2 3.2 1.5e-58 198.7 0.0 2.5 2 1 0 2 2 2 1 SPX domain Coq4 PF05019.8 CCF35822.1 - 1.1e-94 315.4 0.0 1.4e-94 315.2 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 SET PF00856.23 CCF35823.1 - 1.6e-09 38.2 0.0 4e-09 36.9 0.0 1.8 2 0 0 2 2 2 1 SET domain RRM_6 PF14259.1 CCF35824.1 - 4.9e-05 23.2 0.0 9.2e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CCF35824.1 - 8.8e-05 22.0 0.0 0.00016 21.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF35824.1 - 0.0062 16.3 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tht1 PF04163.7 CCF35825.1 - 6.8e-10 37.9 5.3 1.4e-09 36.8 3.7 1.4 1 1 0 1 1 1 1 Tht1-like nuclear fusion protein Allexi_40kDa PF05549.6 CCF35825.1 - 0.028 13.7 3.6 0.044 13.0 2.5 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein DUF1664 PF07889.7 CCF35825.1 - 0.25 11.1 5.1 0.25 11.1 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CN_hydrolase PF00795.17 CCF35826.1 - 5.8e-28 97.5 0.0 7.9e-28 97.0 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Fungal_trans PF04082.13 CCF35827.1 - 3.6e-18 65.3 0.0 4.9e-18 64.9 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sugar_tr PF00083.19 CCF35828.1 - 4.5e-80 269.4 25.8 5.2e-80 269.2 17.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF35828.1 - 1e-18 67.2 30.0 1e-18 67.2 20.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SIR2 PF02146.12 CCF35830.1 - 2e-29 102.5 0.0 3e-09 36.8 0.0 3.2 3 0 0 3 3 3 3 Sir2 family RCC1 PF00415.13 CCF35832.1 - 2.2e-51 171.8 4.9 3.5e-08 33.5 0.0 7.6 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CCF35832.1 - 3.1e-33 112.6 35.5 1.4e-08 34.0 0.2 6.3 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat Amidase PF01425.16 CCF35834.1 - 2e-58 198.3 0.7 2.6e-58 197.9 0.5 1.1 1 0 0 1 1 1 1 Amidase CN_hydrolase PF00795.17 CCF35835.1 - 1.3e-24 86.5 0.0 2.1e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase adh_short PF00106.20 CCF35836.1 - 1.5e-18 67.2 0.0 3.1e-18 66.2 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF35836.1 - 4.1e-09 36.3 0.0 6.3e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF35836.1 - 4.4e-07 29.9 0.0 8.2e-07 29.0 0.0 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.3 CCF35836.1 - 0.0032 17.2 0.1 0.0085 15.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Epimerase PF01370.16 CCF35836.1 - 0.014 14.8 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 CCF35836.1 - 0.019 13.8 0.0 0.028 13.3 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Glyco_tran_WecB PF03808.8 CCF35836.1 - 0.025 13.9 0.0 0.047 13.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family WD40 PF00400.27 CCF35838.1 - 1.2e-42 142.2 17.4 1.1e-08 34.6 0.0 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat eIF2A PF08662.6 CCF35838.1 - 0.0033 17.1 0.0 1.1 8.8 0.0 3.1 1 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 CCF35838.1 - 0.074 11.1 0.0 0.21 9.6 0.0 1.6 1 1 1 2 2 2 0 Nucleoporin Nup120/160 MBOAT PF03062.14 CCF35839.1 - 4.8e-17 62.0 19.7 6.8e-17 61.5 13.7 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.1 CCF35839.1 - 0.003 17.5 1.2 0.0087 16.1 0.9 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family ICMT PF04140.9 CCF35840.1 - 2.6e-28 98.0 0.8 2.6e-28 98.0 0.6 1.7 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 CCF35840.1 - 3.6e-15 55.9 2.5 3.6e-15 55.9 1.7 2.2 2 1 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.7 CCF35840.1 - 5.4e-05 22.6 0.8 0.0001 21.6 0.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Cyclin_N PF00134.18 CCF35841.1 - 6.9e-13 48.2 0.0 1.2e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.6 CCF35841.1 - 4.3e-11 43.4 0.2 4.3e-10 40.1 0.2 2.2 1 1 0 1 1 1 1 Cyclin NAD_binding_2 PF03446.10 CCF35843.1 - 2.1e-34 118.7 0.0 2.5e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.14 CCF35843.1 - 2.3e-05 23.6 0.0 3e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.12 CCF35843.1 - 9e-05 22.8 0.0 0.00015 22.0 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_11 PF14833.1 CCF35843.1 - 0.003 17.6 0.0 0.0046 17.0 0.0 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase ApbA PF02558.11 CCF35843.1 - 0.09 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.9 CCF35843.1 - 0.13 11.6 0.0 4.1 6.7 0.0 2.1 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.13 CCF35843.1 - 0.14 11.8 0.0 1.6 8.3 0.0 2.1 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Beta-lactamase PF00144.19 CCF35844.1 - 4.4e-63 213.3 0.1 5.3e-63 213.0 0.0 1.0 1 0 0 1 1 1 1 Beta-lactamase Hemerythrin PF01814.18 CCF35845.1 - 3e-09 37.1 0.1 4.2e-09 36.6 0.1 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain His_biosynth PF00977.16 CCF35846.1 - 5e-35 120.8 0.0 6.1e-35 120.5 0.0 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Ribul_P_3_epim PF00834.14 CCF35846.1 - 0.031 13.3 0.0 0.049 12.7 0.0 1.2 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family DUF4568 PF15132.1 CCF35847.1 - 0.047 12.8 0.0 0.058 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4568) MFS_1 PF07690.11 CCF35848.1 - 5.8e-24 84.4 26.9 5.8e-24 84.4 18.6 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Dispanin PF04505.7 CCF35848.1 - 0.082 12.4 2.8 0.12 11.8 0.0 2.8 3 0 0 3 3 3 0 Interferon-induced transmembrane protein RhoGAP PF00620.22 CCF35849.1 - 2.8e-06 27.0 0.1 3.4e-06 26.7 0.1 1.1 1 0 0 1 1 1 1 RhoGAP domain Peptidase_M14 PF00246.19 CCF35850.1 - 2.7e-37 128.8 0.9 3.8e-37 128.4 0.6 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase ThuA PF06283.6 CCF35851.1 - 3e-55 187.2 0.1 4.1e-55 186.8 0.1 1.2 1 0 0 1 1 1 1 Trehalose utilisation PLDc_2 PF13091.1 CCF35852.1 - 2.2e-16 59.7 0.0 1e-10 41.4 0.0 2.7 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.17 CCF35852.1 - 0.044 13.6 0.2 3.1 7.7 0.0 2.4 2 0 0 2 2 2 0 Phospholipase D Active site motif Regulator_TrmB PF11495.3 CCF35852.1 - 0.2 10.5 0.2 9.9 5.0 0.0 2.6 3 0 0 3 3 3 0 Archaeal transcriptional regulator TrmB Sulfate_transp PF00916.15 CCF35853.1 - 5.6e-55 186.3 8.0 1.2e-54 185.2 5.5 1.6 1 0 0 1 1 1 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 CCF35853.1 - 1.2e-27 95.3 3.7 1.2e-27 95.3 2.5 4.1 4 1 1 5 5 5 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 CCF35853.1 - 1.5e-11 43.7 0.0 2.7e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.1 CCF35853.1 - 0.082 12.9 0.1 0.28 11.2 0.0 1.9 2 0 0 2 2 2 0 STAS domain Cupin_1 PF00190.17 CCF35854.1 - 3.8e-32 110.6 0.0 1e-15 57.4 0.0 2.1 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.6 CCF35854.1 - 1.2e-26 91.9 1.1 1.4e-13 50.0 0.1 2.5 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.7 CCF35854.1 - 8.5e-09 34.6 0.0 0.0022 17.3 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.14 CCF35854.1 - 3.9e-07 29.8 0.2 0.001 18.7 0.0 2.3 2 0 0 2 2 2 2 AraC-like ligand binding domain MannoseP_isomer PF01050.13 CCF35854.1 - 0.00055 19.5 0.0 0.078 12.5 0.0 2.2 2 0 0 2 2 2 1 Mannose-6-phosphate isomerase ARD PF03079.9 CCF35854.1 - 0.0067 16.3 0.4 1.4 8.8 0.0 2.3 2 0 0 2 2 2 2 ARD/ARD' family GPI PF06560.6 CCF35854.1 - 0.039 12.9 0.0 0.066 12.2 0.0 1.3 1 0 0 1 1 1 0 Glucose-6-phosphate isomerase (GPI) 3-HAO PF06052.7 CCF35854.1 - 0.048 13.0 0.0 0.45 9.9 0.0 2.1 2 0 0 2 2 2 0 3-hydroxyanthranilic acid dioxygenase Pneumo_att_G PF05539.6 CCF35855.1 - 0.37 10.1 15.2 0.5 9.7 10.5 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G DUF3984 PF13136.1 CCF35855.1 - 0.65 9.1 17.8 0.94 8.6 12.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) KAR9 PF08580.5 CCF35855.1 - 2.5 6.2 10.5 2.8 6.0 7.3 1.0 1 0 0 1 1 1 0 Yeast cortical protein KAR9 PAP1 PF08601.5 CCF35855.1 - 2.9 7.4 12.9 3.3 7.2 9.0 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 Gag_spuma PF03276.9 CCF35855.1 - 6.2 5.0 11.1 7.8 4.6 7.7 1.1 1 0 0 1 1 1 0 Spumavirus gag protein DUF3774 PF12609.3 CCF35856.1 - 0.016 16.0 0.5 0.023 15.5 0.3 1.3 1 0 0 1 1 1 0 Wound-induced protein Prp19 PF08606.6 CCF35856.1 - 0.062 13.0 0.0 0.11 12.2 0.0 1.7 1 1 0 1 1 1 0 Prp19/Pso4-like adh_short PF00106.20 CCF35857.1 - 2.1e-22 79.8 4.2 3.4e-22 79.1 2.9 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF35857.1 - 2.7e-08 33.8 0.1 2.2e-07 30.9 0.0 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF35857.1 - 4.9e-07 29.5 1.0 7.1e-07 29.0 0.7 1.3 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.15 CCF35857.1 - 0.0053 16.8 0.0 0.0084 16.2 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.10 CCF35857.1 - 0.025 13.4 0.0 0.035 13.0 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.16 CCF35857.1 - 0.082 12.3 0.2 0.15 11.4 0.2 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family STAS_2 PF13466.1 CCF35857.1 - 0.83 9.7 4.8 32 4.6 0.3 3.3 3 0 0 3 3 3 0 STAS domain p450 PF00067.17 CCF35858.1 - 3.5e-71 240.1 0.0 4.2e-71 239.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF348 PF03990.9 CCF35858.1 - 0.22 11.1 3.0 35 4.0 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF348) Cyt-b5 PF00173.23 CCF35859.1 - 7.6e-05 22.4 0.0 8.8e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Fer2 PF00111.22 CCF35860.1 - 0.033 13.9 0.5 0.067 12.9 0.4 1.6 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Cu_bind_like PF02298.12 CCF35860.1 - 0.07 12.9 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 Plastocyanin-like domain Arrestin_N PF00339.24 CCF35861.1 - 1.6e-19 70.2 0.0 2.6e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 CCF35861.1 - 1.2e-15 57.8 0.0 5.3e-15 55.7 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.2 CCF35861.1 - 0.00024 20.6 0.0 0.00064 19.2 0.0 1.7 2 0 0 2 2 2 1 Arrestin_N terminal like DUF2140 PF09911.4 CCF35861.1 - 0.2 10.8 0.0 0.34 10.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) zf-H2C2_2 PF13465.1 CCF35864.1 - 0.0016 18.6 2.1 0.2 11.9 0.2 2.3 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 CCF35864.1 - 0.056 13.8 6.3 0.11 12.8 1.0 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF35864.1 - 0.12 12.7 12.1 0.34 11.3 3.5 2.7 2 1 0 2 2 2 0 Zinc finger, C2H2 type TauD PF02668.11 CCF35865.1 - 2.2e-16 60.3 0.1 2.6e-16 60.1 0.1 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Epimerase PF01370.16 CCF35866.1 - 1.1e-10 41.3 0.0 1.5e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF35866.1 - 1.5e-06 28.3 0.0 2.4e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 CCF35866.1 - 0.0025 16.7 0.0 0.43 9.4 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein KR PF08659.5 CCF35866.1 - 0.081 12.5 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 KR domain Rab5ip PF07019.7 CCF35866.1 - 0.19 11.8 0.2 0.19 11.8 0.2 1.9 2 0 0 2 2 2 0 Rab5-interacting protein (Rab5ip) HhH-GPD PF00730.20 CCF35867.1 - 0.00088 19.5 0.0 0.0017 18.6 0.0 1.6 1 1 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Cupredoxin_1 PF13473.1 CCF35868.1 - 0.029 14.2 1.1 1.5 8.7 0.0 2.5 2 1 1 3 3 3 0 Cupredoxin-like domain DUF3108 PF11306.3 CCF35868.1 - 0.09 12.4 1.4 0.11 12.1 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3108) ADH_zinc_N PF00107.21 CCF35870.1 - 8.1e-12 44.8 0.0 1.5e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF35870.1 - 0.00017 21.3 0.2 0.00087 19.0 0.1 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain MCM PF00493.18 CCF35871.1 - 1.2e-110 369.3 0.2 1.8e-110 368.8 0.2 1.2 1 0 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 CCF35871.1 - 7.3e-08 31.8 0.0 1.4e-06 27.6 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 CCF35871.1 - 0.0028 17.2 0.0 0.0056 16.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 CCF35871.1 - 0.0069 15.8 0.0 0.02 14.3 0.0 1.7 2 0 0 2 2 2 1 Sigma-54 interaction domain PfkB PF00294.19 CCF35872.1 - 2.5e-15 56.4 0.1 5.5e-09 35.5 0.4 2.1 2 0 0 2 2 2 2 pfkB family carbohydrate kinase CAP_N PF01213.14 CCF35874.1 - 2.9e-49 168.0 7.9 4.1e-49 167.5 5.4 1.4 1 1 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal DUF2360 PF10152.4 CCF35874.1 - 0.048 13.9 4.2 0.069 13.4 2.9 1.2 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) PARP PF00644.15 CCF35875.1 - 4.3e-15 55.6 0.2 1.1e-14 54.4 0.1 1.6 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain UQ_con PF00179.21 CCF35875.1 - 5.8e-07 29.0 0.0 1.2e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme GvpH PF05455.6 CCF35875.1 - 0.0055 16.3 0.1 0.012 15.2 0.1 1.5 1 0 0 1 1 1 1 GvpH TMEM171 PF15471.1 CCF35876.1 - 3 6.5 7.4 10 4.7 1.7 2.1 1 1 0 2 2 2 0 Transmembrane protein family 171 EI24 PF07264.6 CCF35877.1 - 1.1e-06 28.2 6.8 3.5e-06 26.6 4.7 1.8 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DUF2383 PF09537.5 CCF35878.1 - 0.23 11.6 1.6 0.29 11.4 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2383) Epimerase PF01370.16 CCF35879.1 - 9.1e-20 71.1 0.0 2.2e-19 69.8 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF35879.1 - 2e-13 49.7 0.0 2.7e-13 49.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 CCF35879.1 - 2.8e-11 43.7 0.3 2.9e-10 40.4 0.1 2.3 2 1 0 2 2 2 1 NADH(P)-binding NAD_binding_4 PF07993.7 CCF35879.1 - 4.7e-09 35.5 0.1 1.2e-07 30.9 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 CCF35879.1 - 3.5e-07 30.2 0.0 7.6e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.10 CCF35879.1 - 3.5e-06 26.1 0.0 5.1e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.5 CCF35879.1 - 3.7e-05 23.4 0.0 9.7e-05 22.1 0.0 1.7 1 1 0 1 1 1 1 KR domain NmrA PF05368.8 CCF35879.1 - 0.0018 17.5 0.2 0.012 14.9 0.1 2.2 1 1 0 1 1 1 1 NmrA-like family DUF3425 PF11905.3 CCF35880.1 - 5e-27 94.4 0.7 8e-27 93.7 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) His_Phos_2 PF00328.17 CCF35881.1 - 1.6e-13 50.7 0.0 2.1e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Crust_neuro_H PF03858.8 CCF35881.1 - 0.0014 19.1 0.1 0.0028 18.2 0.1 1.5 1 0 0 1 1 1 1 Crustacean neurohormone H His_Phos_1 PF00300.17 CCF35881.1 - 0.0024 18.0 0.0 0.0035 17.4 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Fungal_trans PF04082.13 CCF35882.1 - 6.9e-23 80.8 0.3 1.1e-22 80.2 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF35882.1 - 1.3e-07 31.4 9.0 2.7e-07 30.3 6.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CBF_beta PF02312.12 CCF35882.1 - 0.21 11.1 0.0 0.39 10.3 0.0 1.4 1 0 0 1 1 1 0 Core binding factor beta subunit Abhydrolase_6 PF12697.2 CCF35883.1 - 1e-05 25.5 0.0 2.5e-05 24.2 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Gryzun PF07919.7 CCF35884.1 - 1.9e-97 326.8 0.0 2.4e-97 326.5 0.0 1.1 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Foie-gras_1 PF11817.3 CCF35884.1 - 5.7e-80 268.3 4.8 1.9e-76 256.8 2.6 2.2 2 0 0 2 2 2 2 Foie gras liver health family 1 Gryzun-like PF12742.2 CCF35884.1 - 0.0025 17.5 0.0 0.005 16.6 0.0 1.6 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking RXT2_N PF08595.6 CCF35885.1 - 5.4e-08 32.7 2.2 1.1e-07 31.7 0.2 2.3 1 1 1 2 2 2 1 RXT2-like, N-terminal DUF3295 PF11702.3 CCF35885.1 - 0.1 11.5 0.4 0.12 11.3 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) CAF1A PF12253.3 CCF35885.1 - 0.13 12.3 1.1 8.1 6.6 0.3 2.1 2 0 0 2 2 2 0 Chromatin assembly factor 1 subunit A HpcH_HpaI PF03328.9 CCF35886.1 - 5.1e-30 104.0 0.0 6.2e-30 103.7 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PK PF00224.16 CCF35886.1 - 0.0076 14.9 0.2 0.011 14.3 0.2 1.2 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain Fungal_trans PF04082.13 CCF35888.1 - 3.8e-21 75.1 2.0 5.7e-20 71.2 0.1 2.7 2 1 1 3 3 3 2 Fungal specific transcription factor domain Med11 PF10280.4 CCF35889.1 - 0.0024 17.9 0.3 0.0028 17.6 0.2 1.1 1 0 0 1 1 1 1 Mediator complex protein Not3 PF04065.10 CCF35889.1 - 0.0028 16.9 0.7 0.0031 16.8 0.5 1.1 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component Laps PF10169.4 CCF35889.1 - 0.0084 16.3 0.6 0.012 15.8 0.4 1.3 1 0 0 1 1 1 1 Learning-associated protein GAS PF13851.1 CCF35889.1 - 0.01 15.0 3.3 0.012 14.8 2.3 1.0 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF2422 PF10337.4 CCF35889.1 - 0.1 11.3 0.1 0.12 11.1 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) Dzip-like_N PF13815.1 CCF35889.1 - 0.13 12.0 0.9 0.18 11.6 0.6 1.2 1 0 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal Secretogranin_V PF05281.6 CCF35889.1 - 0.14 11.4 0.4 0.24 10.7 0.3 1.5 1 1 0 1 1 1 0 Neuroendocrine protein 7B2 precursor (Secretogranin V) Noelin-1 PF12308.3 CCF35889.1 - 0.45 10.3 2.7 1.7 8.4 1.9 1.8 1 1 0 1 1 1 0 Neurogenesis glycoprotein Peptidase_M9_N PF08453.5 CCF35891.1 - 0.089 12.1 0.1 0.11 11.8 0.1 1.1 1 0 0 1 1 1 0 Peptidase family M9 N-terminal Herpes_LMP2 PF07415.6 CCF35892.1 - 7.1 5.0 8.4 8.6 4.8 5.8 1.1 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein Fungal_trans PF04082.13 CCF35893.1 - 2.2e-25 88.9 0.1 3.9e-25 88.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF35893.1 - 3.8e-08 33.0 12.1 3.8e-08 33.0 8.4 2.9 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DNA_photolyase PF00875.13 CCF35894.1 - 1.6e-38 132.0 0.0 2.8e-38 131.2 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase FAD_binding_7 PF03441.9 CCF35894.1 - 4.6e-21 75.2 0.1 1.2e-20 73.9 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain of DNA photolyase HAUS6_N PF14661.1 CCF35894.1 - 0.061 12.6 0.0 0.16 11.2 0.0 1.6 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus CactinC_cactus PF09732.4 CCF35895.1 - 2.1e-50 169.4 1.7 3.6e-50 168.7 1.2 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.4 CCF35895.1 - 3.8e-45 153.5 9.1 2.7e-23 82.2 0.5 2.2 1 1 1 2 2 2 2 Conserved mid region of cactin Spc7 PF08317.6 CCF35895.1 - 0.031 12.9 1.6 0.05 12.2 1.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein WD40 PF00400.27 CCF35898.1 - 3.4e-13 48.9 15.5 3e-06 26.9 0.6 3.9 5 0 0 5 5 5 3 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 CCF35898.1 - 0.0085 14.4 0.0 0.011 14.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome D1 heme domain Lactamase_B_4 PF13691.1 CCF35898.1 - 0.11 11.9 0.0 0.53 9.8 0.0 1.9 2 0 0 2 2 2 0 tRNase Z endonuclease zf-C2H2_4 PF13894.1 CCF35899.1 - 1.1 9.7 9.2 7 7.2 0.3 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger adh_short PF00106.20 CCF35900.1 - 5.6e-16 58.8 0.1 8.1e-16 58.3 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF35900.1 - 4.3e-08 33.2 0.0 5.4e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF35900.1 - 4.5e-06 26.4 0.0 6.6e-06 25.9 0.0 1.4 1 1 0 1 1 1 1 KR domain DUF2620 PF10941.3 CCF35900.1 - 0.062 13.3 0.2 0.12 12.4 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF2620 zf-CCCH PF00642.19 CCF35901.1 - 1.8e-05 24.2 8.5 2e-05 24.1 0.7 2.8 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Ost4 PF10215.4 CCF35902.1 - 7.3e-20 70.1 0.2 8.4e-20 69.9 0.1 1.1 1 0 0 1 1 1 1 Oligosaccaryltransferase COX7a PF02238.10 CCF35902.1 - 0.12 12.1 0.1 0.13 11.9 0.1 1.1 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIIa RRM_1 PF00076.17 CCF35903.1 - 1.1e-15 57.0 0.0 1.7e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF35903.1 - 6e-13 48.5 0.0 9.1e-13 47.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF35903.1 - 4.8e-07 29.5 0.0 8.8e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 CCF35903.1 - 0.00047 20.5 1.7 0.00047 20.5 1.2 3.0 2 1 1 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 Smg4_UPF3 PF03467.10 CCF35903.1 - 0.006 16.6 0.0 0.0083 16.1 0.0 1.3 1 0 0 1 1 1 1 Smg-4/UPF3 family CS PF04969.11 CCF35904.1 - 1.5e-10 41.4 0.0 2.5e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 CS domain Snf7 PF03357.16 CCF35905.1 - 6.8e-25 87.4 12.6 6.8e-25 87.4 8.7 2.0 2 0 0 2 2 2 1 Snf7 DASH_Duo1 PF08651.5 CCF35905.1 - 0.31 10.6 2.6 1.8 8.2 0.2 2.8 2 1 1 3 3 3 0 DASH complex subunit Duo1 TPR_MLP1_2 PF07926.7 CCF35905.1 - 1.1 9.0 11.5 3.1 7.5 7.9 2.0 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.4 CCF35905.1 - 2.6 6.9 9.2 4.3 6.2 6.4 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 GAS PF13851.1 CCF35905.1 - 3.1 6.9 12.8 0.14 11.2 4.7 1.7 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding PWWP PF00855.12 CCF35906.1 - 3.3e-14 52.8 0.0 3.3e-14 52.8 0.0 3.4 1 1 1 2 2 2 1 PWWP domain Sec63 PF02889.11 CCF35907.1 - 3.9e-186 617.6 0.2 5e-99 331.4 0.0 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 CCF35907.1 - 2.7e-20 72.5 0.0 1.4e-19 70.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 CCF35907.1 - 4.8e-06 26.5 0.0 1.1e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_10 PF12846.2 CCF35907.1 - 0.097 12.0 0.0 0.66 9.3 0.0 2.4 1 1 1 2 2 2 0 AAA-like domain PhoH PF02562.11 CCF35907.1 - 0.1 11.8 0.0 0.24 10.5 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein DUF2075 PF09848.4 CCF35907.1 - 0.19 10.6 0.0 0.28 10.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) WD40 PF00400.27 CCF35908.1 - 2.1e-56 185.8 16.5 1e-08 34.6 0.0 8.4 8 0 0 8 8 8 7 WD domain, G-beta repeat F-box PF00646.28 CCF35908.1 - 7.5e-11 41.3 0.8 3.9e-10 39.1 0.2 2.4 2 1 0 2 2 2 1 F-box domain F-box-like PF12937.2 CCF35908.1 - 1e-10 41.1 0.1 2.1e-10 40.1 0.1 1.6 1 0 0 1 1 1 1 F-box-like PQQ_2 PF13360.1 CCF35908.1 - 0.00041 19.8 0.5 1 8.7 0.0 3.2 3 0 0 3 3 3 2 PQQ-like domain ABC2_membrane PF01061.19 CCF35910.1 - 5e-82 274.1 61.9 1.3e-42 145.4 14.3 2.7 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.22 CCF35910.1 - 1.6e-35 122.3 0.0 3e-16 59.9 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.7 CCF35910.1 - 3.3e-28 97.3 1.5 1.4e-24 85.6 0.0 3.2 3 0 0 3 3 3 2 CDR ABC transporter ABC_trans_N PF14510.1 CCF35910.1 - 8e-10 38.6 0.1 3.1e-09 36.7 0.0 2.1 2 0 0 2 2 1 1 ABC-transporter extracellular N-terminal AAA_33 PF13671.1 CCF35910.1 - 5.5e-07 29.5 0.0 0.0029 17.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 CCF35910.1 - 4.9e-06 26.0 0.1 0.0035 16.7 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.1 CCF35910.1 - 8.2e-06 25.2 0.1 0.005 16.3 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC2_membrane_3 PF12698.2 CCF35910.1 - 1e-05 24.7 47.3 0.0013 17.8 14.8 3.0 2 1 1 3 3 3 2 ABC-2 family transporter protein AAA_17 PF13207.1 CCF35910.1 - 1.4e-05 25.9 0.1 0.0012 19.6 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_21 PF13304.1 CCF35910.1 - 2e-05 24.7 0.1 0.088 12.7 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_22 PF13401.1 CCF35910.1 - 6.6e-05 23.0 0.0 0.095 12.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 CCF35910.1 - 0.00022 20.4 0.0 0.003 16.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 CCF35910.1 - 0.00081 19.4 0.5 0.19 11.7 0.1 2.9 2 1 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.14 CCF35910.1 - 0.0011 18.2 0.0 0.68 9.1 0.0 3.5 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_28 PF13521.1 CCF35910.1 - 0.0016 18.4 0.9 0.022 14.7 0.0 2.9 3 0 0 3 3 3 1 AAA domain cobW PF02492.14 CCF35910.1 - 0.0022 17.4 1.7 0.0096 15.3 0.3 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.13 CCF35910.1 - 0.0046 16.4 0.1 0.48 9.8 0.1 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family UPF0079 PF02367.12 CCF35910.1 - 0.0059 16.2 0.4 0.93 9.1 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_18 PF13238.1 CCF35910.1 - 0.007 16.6 0.0 0.25 11.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 CCF35910.1 - 0.011 15.4 0.8 4.5 6.8 0.1 2.4 2 0 0 2 2 2 0 NACHT domain AAA_19 PF13245.1 CCF35910.1 - 0.016 14.9 1.1 4.5 7.0 0.2 3.1 3 0 0 3 3 3 0 Part of AAA domain AAA_10 PF12846.2 CCF35910.1 - 0.046 13.1 0.3 2.5 7.4 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain Miro PF08477.8 CCF35910.1 - 0.17 12.3 0.2 9.2 6.7 0.0 2.7 2 0 0 2 2 2 0 Miro-like protein AAA_23 PF13476.1 CCF35910.1 - 0.23 11.7 1.6 0.53 10.5 0.0 2.3 3 0 0 3 3 2 0 AAA domain AAA_15 PF13175.1 CCF35910.1 - 0.25 10.3 0.0 1.8 7.5 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain SUI1 PF01253.17 CCF35911.1 - 1e-22 79.7 0.4 2.3e-22 78.5 0.3 1.6 1 0 0 1 1 1 1 Translation initiation factor SUI1 TnpV PF14198.1 CCF35911.1 - 0.0021 17.9 0.0 0.0039 17.0 0.0 1.4 1 0 0 1 1 1 1 Transposon-encoded protein TnpV She9_MDM33 PF05546.6 CCF35911.1 - 0.044 13.3 0.4 0.071 12.6 0.3 1.3 1 0 0 1 1 1 0 She9 / Mdm33 family Nbl1_Borealin_N PF10444.4 CCF35912.1 - 1.3e-19 69.2 6.3 2.2e-19 68.5 4.4 1.3 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal VWA_2 PF13519.1 CCF35913.1 - 2.6e-15 56.9 0.1 3.6e-15 56.5 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.9 CCF35913.1 - 2.1e-07 30.7 0.0 2.9e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like VWA PF00092.23 CCF35913.1 - 8.5e-07 28.8 1.0 1.3e-06 28.2 0.7 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain UIM PF02809.15 CCF35913.1 - 0.0011 18.3 1.1 0.0034 16.8 0.8 1.9 1 0 0 1 1 1 1 Ubiquitin interaction motif DUF243 PF03103.12 CCF35913.1 - 0.062 13.4 0.1 0.15 12.1 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF243) Sybindin PF04099.7 CCF35914.1 - 7.8e-53 178.0 0.0 9.5e-53 177.7 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.8 CCF35914.1 - 2.5e-08 33.8 0.1 4.9e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region IBN_N PF03810.14 CCF35915.1 - 6.1e-11 42.0 0.1 1.4e-09 37.7 0.0 2.9 2 0 0 2 2 2 1 Importin-beta N-terminal domain CAS_CSE1 PF03378.10 CCF35915.1 - 0.0023 16.2 0.0 0.0044 15.3 0.0 1.4 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus Xpo1 PF08389.7 CCF35915.1 - 0.0064 16.4 0.1 14 5.6 0.0 4.4 4 0 0 4 4 4 1 Exportin 1-like protein SR-25 PF10500.4 CCF35916.1 - 0.059 12.8 4.4 0.051 13.0 3.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1479 PF07350.7 CCF35917.1 - 0.04 12.4 0.0 0.047 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) PQQ PF01011.16 CCF35918.1 - 0.13 11.8 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 PQQ enzyme repeat BBE PF08031.7 CCF35920.1 - 4.2e-13 48.9 0.0 8.9e-13 47.9 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like FAD_binding_4 PF01565.18 CCF35920.1 - 2.8e-08 33.3 0.0 0.0002 20.8 0.0 3.0 2 1 1 3 3 3 2 FAD binding domain Cytokin-bind PF09265.5 CCF35920.1 - 0.081 12.0 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Glyco_hydro_43 PF04616.9 CCF35921.1 - 4.2e-105 350.9 0.8 5.8e-105 350.4 0.2 1.5 2 0 0 2 2 2 1 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.15 CCF35921.1 - 0.057 12.7 0.2 0.13 11.6 0.1 1.5 1 1 0 1 1 1 0 Glycosyl hydrolases family 32 N-terminal domain Ada3 PF10198.4 CCF35922.1 - 1.7e-45 153.9 3.7 3.6e-45 152.9 0.0 2.7 2 1 0 2 2 2 1 Histone acetyltransferases subunit 3 zf-C2H2_2 PF12756.2 CCF35923.1 - 0.039 14.0 0.0 0.057 13.5 0.0 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) DUF188 PF02639.9 CCF35923.1 - 0.16 11.4 0.1 0.32 10.4 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized BCR, YaiI/YqxD family COG1671 zf-met PF12874.2 CCF35923.1 - 2 8.7 4.2 0.52 10.5 0.3 1.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Prenyltrans PF00432.16 CCF35924.1 - 3.6e-57 189.5 8.6 1.9e-11 43.3 0.0 6.1 6 0 0 6 6 6 6 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 CCF35924.1 - 8.5e-36 122.7 0.0 2.2e-15 57.0 0.0 4.0 1 1 3 4 4 4 4 Prenyltransferase-like Prenyltrans_1 PF13243.1 CCF35924.1 - 9.1e-12 44.9 0.0 6.9e-05 22.8 0.0 2.6 1 1 2 3 3 3 2 Prenyltransferase-like Latrophilin PF02354.11 CCF35925.1 - 0.054 12.2 0.0 0.063 11.9 0.0 1.1 1 0 0 1 1 1 0 Latrophilin Cytoplasmic C-terminal region PUF PF00806.14 CCF35926.1 - 0.014 14.8 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 Pumilio-family RNA binding repeat Aspzincin_M35 PF14521.1 CCF35927.1 - 3.6e-06 27.5 0.0 7.3e-06 26.5 0.0 1.5 1 1 0 1 1 1 1 Lysine-specific metallo-endopeptidase Peptidase_M35 PF02102.10 CCF35927.1 - 0.0007 18.3 0.0 0.001 17.8 0.0 1.2 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family HRXXH PF13933.1 CCF35927.1 - 0.003 16.9 0.0 0.38 10.1 0.0 2.1 2 0 0 2 2 2 2 Putative peptidase family Cut8_N PF14482.1 CCF35929.1 - 0.068 13.1 1.7 0.1 12.6 1.2 1.2 1 0 0 1 1 1 0 Cut8 proteasome-binding domain Trypan_PARP PF05887.6 CCF35929.1 - 8.3 6.2 10.6 3.4 7.4 6.0 1.4 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) MFS_1 PF07690.11 CCF35930.1 - 4.9e-32 111.0 22.1 4.9e-32 111.0 15.4 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_S49_N PF08496.5 CCF35933.1 - 0.43 10.3 6.0 0.84 9.4 4.2 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal BLVR PF06375.6 CCF35933.1 - 1.9 8.2 13.7 0.32 10.7 4.9 2.8 2 1 0 3 3 3 0 Bovine leukaemia virus receptor (BLVR) Coatomer_E PF04733.9 CCF35934.1 - 2e-62 211.0 6.1 2.3e-62 210.8 4.3 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit Apc3 PF12895.2 CCF35934.1 - 3e-06 27.2 0.4 0.37 10.9 0.0 3.5 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.1 CCF35934.1 - 5.6e-06 25.6 4.5 0.016 14.2 2.7 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 CCF35934.1 - 8.8e-06 25.9 14.3 0.034 14.7 2.1 5.8 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.1 CCF35934.1 - 6.3e-05 23.2 23.7 0.032 14.5 2.3 4.4 5 0 0 5 5 5 2 Tetratricopeptide repeat Type_III_YscG PF09477.5 CCF35934.1 - 0.00044 20.3 6.2 0.011 15.7 0.0 3.7 1 1 2 3 3 3 1 Bacterial type II secretion system chaperone protein (type_III_yscG) TPR_11 PF13414.1 CCF35934.1 - 0.0018 17.8 3.1 0.15 11.7 0.0 4.2 3 1 0 3 3 3 1 TPR repeat TPR_16 PF13432.1 CCF35934.1 - 0.0018 18.8 18.9 0.4 11.4 5.0 5.3 3 3 1 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 CCF35934.1 - 0.0041 16.8 0.2 2.1 8.3 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 CCF35934.1 - 0.0092 15.5 3.8 1.9 8.2 0.1 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.1 CCF35934.1 - 0.015 15.0 8.3 15 5.6 0.4 5.7 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_4 PF07721.9 CCF35934.1 - 0.029 14.7 3.3 0.095 13.1 0.9 5.2 8 0 0 8 8 5 0 Tetratricopeptide repeat TPR_12 PF13424.1 CCF35934.1 - 0.056 13.3 12.0 1.5 8.7 0.6 4.9 2 2 4 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.12 CCF35934.1 - 0.11 12.5 0.4 0.11 12.5 0.3 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.1 CCF35934.1 - 0.23 11.4 8.2 5.3 7.1 0.4 4.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.1 CCF35934.1 - 0.51 10.9 7.6 12 6.6 0.1 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_9 PF13371.1 CCF35934.1 - 1.1 9.1 5.6 8.9 6.2 0.4 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Ferritin_2 PF13668.1 CCF35935.1 - 1.8e-41 141.3 0.3 2.7e-41 140.7 0.2 1.3 1 0 0 1 1 1 1 Ferritin-like domain Phage_CII PF05269.6 CCF35936.1 - 0.13 12.2 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage CII protein Epimerase PF01370.16 CCF35937.1 - 1.2e-12 47.7 0.0 1.9e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF35937.1 - 7.7e-10 39.0 2.3 2.3e-08 34.2 1.6 2.7 1 1 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 CCF35937.1 - 1e-07 30.9 0.0 3.2e-07 29.3 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 CCF35937.1 - 2.7e-05 23.2 0.0 4.5e-05 22.4 0.0 1.5 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 CCF35937.1 - 0.012 15.5 1.8 0.021 14.7 0.1 2.1 2 0 0 2 2 2 0 short chain dehydrogenase Polysacc_synt_2 PF02719.10 CCF35937.1 - 0.017 14.0 0.0 0.029 13.2 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NmrA PF05368.8 CCF35937.1 - 0.078 12.2 0.0 0.17 11.1 0.0 1.6 1 0 0 1 1 1 0 NmrA-like family CENP-T PF15511.1 CCF35938.1 - 2.6e-103 346.4 24.8 2.6e-103 346.4 17.2 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T CENP-S PF15630.1 CCF35938.1 - 4.2e-08 33.2 0.0 8.1e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Kinetochore component CENP-S Histone PF00125.19 CCF35938.1 - 3.1e-06 27.2 0.0 5.9e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 CCF35938.1 - 6e-05 23.0 0.0 0.00012 22.1 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SURF1 PF02104.10 CCF35939.1 - 5.6e-14 52.4 0.0 6.4e-14 52.2 0.0 1.1 1 0 0 1 1 1 1 SURF1 family Ubiq_cyt_C_chap PF03981.7 CCF35940.1 - 7.5e-36 123.0 1.7 1.6e-35 122.0 1.2 1.5 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone DHFR_1 PF00186.14 CCF35941.1 - 1.9e-24 86.0 0.0 1.2e-23 83.4 0.0 2.4 1 1 0 1 1 1 1 Dihydrofolate reductase tRNA-synt_1 PF00133.17 CCF35944.1 - 7.5e-124 413.9 0.0 8.9e-124 413.6 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 CCF35944.1 - 1.9e-15 56.4 0.0 1e-10 40.8 0.0 2.4 2 1 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 CCF35944.1 - 0.1 11.9 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 Mitoc_L55 PF09776.4 CCF35945.1 - 1.3 8.6 6.8 0.071 12.6 0.5 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L55 Abhydrolase_6 PF12697.2 CCF35947.1 - 1.4e-28 100.3 0.6 4.2e-28 98.7 0.4 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF35947.1 - 1.6e-15 57.2 0.1 2.2e-14 53.6 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF35947.1 - 1e-11 44.8 0.0 2e-11 43.8 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CCF35947.1 - 5.6e-05 22.9 0.0 9.8e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Putative lysophospholipase Ndr PF03096.9 CCF35947.1 - 0.0013 17.2 0.0 0.0019 16.7 0.0 1.1 1 0 0 1 1 1 1 Ndr family MMR_HSR1 PF01926.18 CCF35948.1 - 1.2e-18 67.1 0.1 6e-18 64.8 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CCF35948.1 - 3.1e-10 39.5 0.1 1.9e-09 36.9 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 CCF35948.1 - 2.2e-05 24.3 0.2 0.0081 15.9 0.0 2.4 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.22 CCF35948.1 - 0.0001 21.7 0.7 1.6 8.1 0.0 4.0 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain Miro PF08477.8 CCF35948.1 - 0.0027 18.1 0.0 0.042 14.3 0.0 2.4 2 0 0 2 2 2 1 Miro-like protein ArgK PF03308.11 CCF35948.1 - 0.0043 15.8 0.2 0.012 14.3 0.1 1.8 2 0 0 2 2 2 1 ArgK protein AIG1 PF04548.11 CCF35948.1 - 0.011 14.9 0.0 0.015 14.3 0.0 1.2 1 0 0 1 1 1 0 AIG1 family Arf PF00025.16 CCF35948.1 - 0.029 13.6 0.3 6.6 5.9 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family p450 PF00067.17 CCF35951.1 - 3.8e-55 187.2 0.0 4.8e-55 186.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 GMC_oxred_C PF05199.8 CCF35951.1 - 0.11 12.8 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 GMC oxidoreductase FAD_binding_3 PF01494.14 CCF35952.1 - 1.4e-26 93.4 0.7 3.5e-25 88.8 0.5 2.3 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF35952.1 - 1e-06 27.9 2.5 0.00041 19.3 0.9 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 CCF35952.1 - 1.1e-05 24.5 1.4 0.00014 20.9 0.9 2.1 1 1 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 CCF35952.1 - 0.0003 20.7 0.4 0.00087 19.2 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 CCF35952.1 - 0.0013 19.0 2.0 0.0047 17.2 0.3 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF35952.1 - 0.0023 18.0 0.1 0.0054 16.8 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 CCF35952.1 - 0.005 15.9 1.0 1.7 7.6 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase GIDA PF01134.17 CCF35952.1 - 0.013 14.3 0.0 0.02 13.7 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Trp_halogenase PF04820.9 CCF35952.1 - 0.023 13.3 0.8 0.093 11.3 0.1 2.0 1 1 1 2 2 2 0 Tryptophan halogenase FAD_binding_2 PF00890.19 CCF35952.1 - 0.025 13.4 0.9 0.07 11.9 0.3 2.0 2 0 0 2 2 2 0 FAD binding domain Pyr_redox_2 PF07992.9 CCF35952.1 - 0.034 14.0 0.2 0.085 12.7 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 CCF35952.1 - 0.059 12.4 0.0 0.094 11.7 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.9 CCF35952.1 - 0.08 11.3 0.8 1.9 6.8 0.1 2.0 2 0 0 2 2 2 0 HI0933-like protein Peptidase_M43 PF05572.8 CCF35953.1 - 1.4e-13 50.7 0.2 2.1e-13 50.1 0.2 1.4 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_3 PF13582.1 CCF35953.1 - 0.0066 16.9 0.1 0.013 16.0 0.1 1.7 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 CCF35953.1 - 0.013 15.4 0.1 0.024 14.5 0.0 1.4 1 1 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_2 PF13574.1 CCF35953.1 - 0.014 15.4 0.0 0.018 15.1 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like RasGEF PF00617.14 CCF35954.1 - 1.9e-50 171.2 0.3 2.8e-50 170.6 0.2 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 CCF35954.1 - 1.1e-13 51.1 0.1 2.2e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 RasGEF N-terminal motif Ribosomal_S2 PF00318.15 CCF35955.1 - 1.2e-43 148.7 0.0 4.9e-23 81.4 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 Ribosomal_S15 PF00312.17 CCF35956.1 - 1.4e-16 60.0 2.0 2.6e-16 59.1 0.2 2.3 2 1 0 2 2 2 1 Ribosomal protein S15 SpoVR PF04293.8 CCF35956.1 - 9.7 4.4 8.1 2.2 6.5 0.0 2.6 2 1 1 3 3 3 0 SpoVR like protein vATP-synt_AC39 PF01992.11 CCF35957.1 - 2.2e-117 391.9 0.0 2.5e-117 391.7 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit NOP5NT PF08156.8 CCF35958.1 - 2.5e-20 72.4 0.7 2.5e-20 72.4 0.5 1.4 2 0 0 2 2 2 1 NOP5NT (NUC127) domain IMS PF00817.15 CCF35959.1 - 5.3e-41 139.8 0.0 9.8e-41 139.0 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 CCF35959.1 - 5.6e-14 52.1 0.0 1.2e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 CCF35959.1 - 0.044 13.8 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 IMS family HHH motif zf-C2H2_4 PF13894.1 CCF35959.1 - 0.2 12.0 2.0 0.67 10.4 1.4 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger Sugar_tr PF00083.19 CCF35961.1 - 8.1e-119 397.1 22.1 1.1e-118 396.6 15.3 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF35961.1 - 1.8e-28 99.2 48.0 2.2e-24 85.8 18.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ALMT PF11744.3 CCF35961.1 - 0.12 10.9 0.9 0.3 9.6 0.6 1.6 1 0 0 1 1 1 0 Aluminium activated malate transporter eIF-5a PF01287.15 CCF35964.1 - 1.8e-24 85.4 1.2 2.7e-24 84.8 0.8 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold KOW PF00467.24 CCF35964.1 - 6e-05 22.5 0.8 6e-05 22.5 0.6 1.8 2 0 0 2 2 2 1 KOW motif EFP_N PF08207.7 CCF35964.1 - 0.0075 16.1 0.3 0.03 14.1 0.0 2.0 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain RRN7 PF11781.3 CCF35965.1 - 1.6e-05 24.2 1.2 3.2e-05 23.3 0.8 1.5 1 0 0 1 1 1 1 RNA polymerase I-specific transcription initiation factor Rrn7 ubiquitin PF00240.18 CCF35966.1 - 1.4e-34 117.2 0.9 1.8e-34 116.9 0.6 1.1 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.12 CCF35966.1 - 3.3e-30 103.4 9.6 5.1e-30 102.8 6.6 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.3 CCF35966.1 - 3.5e-18 65.0 0.4 5.1e-18 64.5 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 CCF35966.1 - 9.9e-06 25.7 0.1 3.8e-05 23.8 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 CCF35966.1 - 0.0028 17.3 0.0 0.0043 16.7 0.0 1.2 1 0 0 1 1 1 1 Telomere stability and silencing Rad60-SLD_2 PF13881.1 CCF35966.1 - 0.0089 15.9 0.0 0.017 14.9 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 CCF35966.1 - 0.01 16.0 0.1 0.01 15.9 0.0 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain DUF2870 PF11069.3 CCF35966.1 - 0.12 12.4 0.0 0.25 11.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) MFS_1 PF07690.11 CCF35968.1 - 3.8e-30 104.8 38.9 5.1e-30 104.3 26.5 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Ribosomal_L17 PF01196.14 CCF35971.1 - 5.7e-32 110.1 0.1 1.1e-31 109.2 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L17 BBP1_C PF15272.1 CCF35971.1 - 0.047 13.2 0.2 0.066 12.7 0.2 1.2 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal DUF1253 PF06862.7 CCF35972.1 - 1.3e-165 551.0 0.3 2.1e-165 550.4 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1253) SASRP1 PF15160.1 CCF35972.1 - 0.011 14.9 0.8 0.019 14.1 0.5 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated serine-rich protein 1 DUF789 PF05623.7 CCF35972.1 - 3.8 6.8 10.5 0.45 9.9 3.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF789) JAB PF01398.16 CCF35973.1 - 2.7e-14 52.8 0.0 4.6e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF3113 PF11310.3 CCF35973.1 - 0.058 13.0 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3113) zf-C2H2 PF00096.21 CCF35974.1 - 1.6e-08 34.4 13.2 0.00039 20.5 1.5 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CCF35974.1 - 9.5e-07 28.8 10.3 1.6e-06 28.1 1.2 2.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 CCF35974.1 - 8.2e-05 22.6 11.0 0.012 15.8 1.4 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CCF35974.1 - 0.036 14.2 5.9 0.068 13.3 0.5 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CCF35974.1 - 0.038 14.1 1.5 0.038 14.1 1.0 2.6 3 0 0 3 3 3 0 Zinc-finger of C2H2 type BRK PF07533.11 CCF35974.1 - 0.055 12.9 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 BRK domain zf-BED PF02892.10 CCF35974.1 - 4.5 7.0 8.4 9.7 6.0 0.7 2.5 1 1 1 2 2 2 0 BED zinc finger DUF3669 PF12417.3 CCF35975.1 - 1.5e-14 53.4 0.1 1.9e-14 53.1 0.1 1.1 1 0 0 1 1 1 1 Zinc finger protein SPRY PF00622.23 CCF35976.1 - 4.1e-15 55.9 0.0 8.3e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 SPRY domain Thioesterase PF00975.15 CCF35977.1 - 1.3e-11 45.1 0.0 2e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain PP-binding PF00550.20 CCF35977.1 - 1.3e-05 25.3 0.1 2.6e-05 24.3 0.1 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site Fungal_trans_2 PF11951.3 CCF35978.1 - 1e-06 27.6 0.8 1e-06 27.6 0.5 1.8 1 1 1 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF35978.1 - 0.0045 16.8 12.0 0.0082 16.0 8.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain KH_1 PF00013.24 CCF35979.1 - 1.4e-25 88.6 1.6 1.2e-07 31.2 0.2 7.8 8 0 0 8 8 8 5 KH domain KH_3 PF13014.1 CCF35979.1 - 1.5e-23 81.9 2.8 3.8e-05 23.2 0.0 5.7 5 0 0 5 5 5 5 KH domain HAD_2 PF13419.1 CCF35981.1 - 5.2e-35 121.2 0.1 6.9e-35 120.8 0.1 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CCF35981.1 - 3.1e-07 31.0 0.0 7.7e-07 29.7 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CCF35981.1 - 2.1e-05 24.1 0.0 4.1e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Syja_N PF02383.13 CCF35982.1 - 1.7e-84 283.2 0.0 2.9e-84 282.5 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.18 CCF35982.1 - 2.5e-23 83.2 0.0 5.1e-23 82.2 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family COesterase PF00135.23 CCF35985.1 - 2.3e-68 231.2 0.2 4.9e-68 230.1 0.1 1.5 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF35985.1 - 7.1e-07 29.0 0.0 2.1e-06 27.4 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF35985.1 - 0.00044 19.5 0.0 0.00068 18.9 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.15 CCF35985.1 - 0.046 13.1 0.1 0.077 12.3 0.1 1.4 1 0 0 1 1 1 0 Putative esterase Abhydrolase_5 PF12695.2 CCF35985.1 - 0.061 13.0 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family LPAM_2 PF13627.1 CCF35985.1 - 2.2 8.0 6.3 5.2 6.8 4.4 1.6 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site Abhydrolase_6 PF12697.2 CCF35986.1 - 2e-12 47.5 0.0 5.4e-12 46.0 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF35986.1 - 3.5e-09 36.5 0.0 7.4e-09 35.5 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF35986.1 - 1.4e-07 31.3 0.0 1.4e-06 28.1 0.0 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S28 PF05577.7 CCF35986.1 - 0.00092 17.8 0.0 0.0013 17.3 0.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Esterase PF00756.15 CCF35986.1 - 0.01 15.2 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Peptidase_S9 PF00326.16 CCF35986.1 - 0.08 12.1 0.0 0.34 10.1 0.0 1.9 1 1 0 1 1 1 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.3 CCF35986.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 Putative lysophospholipase CENP-O PF09496.5 CCF35988.1 - 4.8e-23 81.1 0.0 9e-23 80.3 0.0 1.5 1 0 0 1 1 1 1 Cenp-O kinetochore centromere component bZIP_2 PF07716.10 CCF35988.1 - 0.16 11.8 1.5 6.2 6.7 0.2 2.5 2 0 0 2 2 2 0 Basic region leucine zipper Cep57_CLD_2 PF14197.1 CCF35988.1 - 0.4 10.6 3.7 0.31 11.0 0.2 2.5 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 Pox_A_type_inc PF04508.7 CCF35988.1 - 5.2 7.1 6.4 1.1 9.1 0.2 2.9 3 1 0 3 3 3 0 Viral A-type inclusion protein repeat Acatn PF13000.2 CCF35989.1 - 1e-153 512.7 25.5 7.6e-79 265.6 6.0 3.1 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 DFP PF04127.10 CCF35990.1 - 4.1e-06 26.5 0.0 0.00063 19.4 0.0 2.1 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein bZIP_1 PF00170.16 CCF35991.1 - 7e-07 29.1 4.8 1.5e-06 28.0 3.3 1.4 1 0 0 1 1 1 1 bZIP transcription factor DUF106 PF01956.11 CCF35991.1 - 2.6 7.5 2.8 5.1 6.5 1.9 1.4 1 0 0 1 1 1 0 Integral membrane protein DUF106 MFS_1 PF07690.11 CCF35992.1 - 1.5e-24 86.4 44.2 2.7e-22 78.9 23.9 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily DIT1_PvcA PF05141.7 CCF35993.1 - 3.5e-76 256.1 0.0 5.1e-76 255.6 0.0 1.2 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein Hydantoinase_A PF01968.13 CCF35994.1 - 1.4e-43 149.0 14.5 6.2e-43 146.9 4.9 3.1 2 1 0 2 2 2 2 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 CCF35994.1 - 5.3e-26 91.1 0.3 4.3e-24 84.9 0.2 2.6 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region BcrAD_BadFG PF01869.15 CCF35994.1 - 0.00029 20.2 3.2 0.0022 17.3 0.1 2.8 3 1 0 3 3 3 1 BadF/BadG/BcrA/BcrD ATPase family MutL PF13941.1 CCF35994.1 - 0.0024 16.2 2.4 0.81 7.9 0.8 2.5 2 0 0 2 2 2 2 MutL protein StbA PF06406.6 CCF35994.1 - 0.17 10.7 3.2 0.64 8.9 0.0 2.8 3 1 0 3 3 3 0 StbA protein Somatostatin PF03002.10 CCF35995.1 - 0.097 12.3 1.4 0.18 11.4 0.2 2.0 2 0 0 2 2 2 0 Somatostatin/Cortistatin family DUF1895 PF08988.5 CCF35996.1 - 0.0022 17.9 0.0 2.4 8.2 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF1895) Aspzincin_M35 PF14521.1 CCF35996.1 - 0.28 11.6 3.6 13 6.2 0.1 4.0 1 1 4 5 5 5 0 Lysine-specific metallo-endopeptidase DUF883 PF05957.8 CCF35996.1 - 0.56 10.6 3.1 2.9 8.3 0.2 2.6 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) MT0933_antitox PF14013.1 CCF35996.1 - 0.62 10.2 14.8 1.5 8.9 1.5 3.5 2 1 0 3 3 3 0 MT0933-like antitoxin protein CsbD PF05532.7 CCF35996.1 - 5.6 6.7 13.1 0.14 11.8 0.4 3.5 4 0 0 4 4 4 0 CsbD-like zf-C2H2 PF00096.21 CCF35997.1 - 0.036 14.4 0.1 0.036 14.4 0.1 2.8 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF35997.1 - 0.46 10.9 4.5 0.33 11.3 0.1 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger SMC_N PF02463.14 CCF35998.1 - 2.5e-59 200.1 2.8 4.1e-58 196.2 1.9 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 CCF35998.1 - 1e-25 90.0 0.0 6.9e-25 87.3 0.0 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 CCF35998.1 - 6.9e-10 39.3 11.1 3.4e-05 23.9 0.1 3.4 3 1 0 3 3 3 2 AAA domain Reo_sigmaC PF04582.7 CCF35998.1 - 1.8e-09 37.2 16.2 0.00079 18.7 0.7 5.2 5 0 0 5 5 5 3 Reovirus sigma C capsid protein AAA_29 PF13555.1 CCF35998.1 - 2.3e-08 33.4 0.0 4.5e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.1 CCF35998.1 - 0.00094 19.5 42.8 0.00094 19.5 29.7 6.5 2 2 1 3 3 3 1 AAA domain MscS_porin PF12795.2 CCF35998.1 - 0.0041 16.4 20.8 0.0041 16.4 14.4 6.6 4 1 2 6 6 6 1 Mechanosensitive ion channel porin domain SbcCD_C PF13558.1 CCF35998.1 - 0.0056 16.5 0.0 0.027 14.3 0.0 2.3 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_13 PF13166.1 CCF35998.1 - 0.48 8.8 109.7 0.017 13.5 16.0 7.0 3 2 2 6 6 6 0 AAA domain Spc7 PF08317.6 CCF35998.1 - 0.61 8.6 101.2 0.016 13.8 10.7 6.8 3 2 4 7 7 7 0 Spc7 kinetochore protein DUF2838 PF10998.3 CCF35999.1 - 1.5e-45 153.6 11.0 1.5e-45 153.6 7.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) Tropomyosin_1 PF12718.2 CCF35999.1 - 0.034 14.0 0.8 0.063 13.1 0.6 1.3 1 0 0 1 1 1 0 Tropomyosin like IncA PF04156.9 CCF35999.1 - 0.1 12.1 1.7 0.2 11.2 1.2 1.4 1 0 0 1 1 1 0 IncA protein Val_tRNA-synt_C PF10458.4 CCF35999.1 - 0.14 12.2 3.7 1.4 9.0 2.1 2.4 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm Apolipoprotein PF01442.13 CCF35999.1 - 0.19 11.2 4.4 0.43 10.0 2.7 1.7 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain TBCA PF02970.11 CCF35999.1 - 0.55 10.3 3.0 0.85 9.7 1.4 1.7 2 0 0 2 2 2 0 Tubulin binding cofactor A WD40 PF00400.27 CCF36000.1 - 2.3e-34 115.9 8.4 1.6e-06 27.7 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.6 CCF36000.1 - 1.1e-08 34.9 0.1 0.00023 20.9 0.0 3.0 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A GMC_oxred_C PF05199.8 CCF36001.1 - 2.5e-35 121.8 0.1 5.6e-35 120.7 0.1 1.6 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.14 CCF36001.1 - 9.4e-34 116.9 0.0 1.3e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase FMN_dh PF01070.13 CCF36002.1 - 1.5e-105 352.9 0.0 1.7e-105 352.7 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.20 CCF36002.1 - 0.00039 19.4 0.1 0.00074 18.4 0.1 1.3 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.16 CCF36002.1 - 0.0025 17.1 0.3 0.017 14.4 0.1 2.0 1 1 0 1 1 1 1 Histidine biosynthesis protein Glu_synthase PF01645.12 CCF36002.1 - 0.0027 16.6 0.1 0.0038 16.2 0.1 1.1 1 0 0 1 1 1 1 Conserved region in glutamate synthase LuxQ-periplasm PF09308.5 CCF36002.1 - 0.18 11.1 0.1 0.27 10.5 0.0 1.1 1 0 0 1 1 1 0 LuxQ, periplasmic AMP-binding PF00501.23 CCF36003.1 - 1.2e-163 544.3 0.0 1.3e-83 280.6 0.0 2.3 2 0 0 2 2 2 2 AMP-binding enzyme NAD_binding_4 PF07993.7 CCF36003.1 - 7.6e-41 139.6 0.0 1.3e-40 138.9 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Condensation PF00668.15 CCF36003.1 - 1.8e-40 138.6 0.0 3e-40 137.9 0.0 1.4 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.20 CCF36003.1 - 5.1e-15 55.4 0.1 9.3e-09 35.4 0.0 3.1 3 0 0 3 3 3 2 Phosphopantetheine attachment site AMP-binding_C PF13193.1 CCF36003.1 - 3e-12 47.2 0.1 2.7e-06 28.2 0.0 3.2 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain Epimerase PF01370.16 CCF36003.1 - 6.8e-08 32.2 0.0 1.7e-07 30.9 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF36003.1 - 0.11 11.1 0.0 0.97 8.0 0.0 2.1 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family DUF1820 PF08850.6 CCF36003.1 - 0.13 12.4 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1820) Polysacc_synt_2 PF02719.10 CCF36003.1 - 0.41 9.4 0.0 1 8.2 0.0 1.6 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein MFS_1 PF07690.11 CCF36004.1 - 5.8e-39 133.7 40.1 1.2e-38 132.7 27.8 1.6 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF36004.1 - 4e-08 32.2 36.7 1.1e-07 30.7 12.1 3.1 1 1 1 3 3 3 2 Sugar (and other) transporter Meth_synt_2 PF01717.13 CCF36005.1 - 3.5e-15 55.8 0.0 5.1e-12 45.4 0.0 2.6 2 1 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain DUF934 PF06073.7 CCF36005.1 - 0.0065 16.1 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF934) Meth_synt_1 PF08267.7 CCF36005.1 - 0.043 13.0 0.0 0.39 9.9 0.0 2.1 2 0 0 2 2 2 0 Cobalamin-independent synthase, N-terminal domain Rhodanese PF00581.15 CCF36006.1 - 9.6e-15 54.9 0.0 1.5e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain Peroxidase_2 PF01328.12 CCF36009.1 - 1.5e-09 37.0 0.4 4.1e-08 32.2 0.3 2.1 1 1 0 1 1 1 1 Peroxidase, family 2 ADH_N PF08240.7 CCF36010.1 - 1.3e-24 86.0 4.4 2.3e-24 85.2 3.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF36010.1 - 1.1e-19 70.2 0.0 1.6e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF36010.1 - 4.8e-10 40.4 0.0 8.4e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 CCF36010.1 - 0.0016 17.6 0.0 0.0025 16.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CBM_10 PF02013.11 CCF36010.1 - 0.086 13.1 1.3 5.7 7.2 0.1 2.7 2 0 0 2 2 2 0 Cellulose or protein binding domain PGAP1 PF07819.8 CCF36011.1 - 1.8e-88 295.9 0.0 2.9e-88 295.2 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.2 CCF36011.1 - 1.3e-05 24.9 0.0 3.3e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF36011.1 - 0.0021 17.9 0.1 0.0021 17.9 0.1 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF36011.1 - 0.027 14.0 0.0 0.054 13.0 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF676 PF05057.9 CCF36011.1 - 0.068 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) COesterase PF00135.23 CCF36011.1 - 0.15 10.7 0.1 0.22 10.2 0.0 1.1 1 0 0 1 1 1 0 Carboxylesterase family Uds1 PF15456.1 CCF36012.1 - 5.2e-39 133.0 12.4 5.2e-39 133.0 8.6 8.2 4 2 4 8 8 8 2 Up-regulated During Septation GAS PF13851.1 CCF36012.1 - 0.0035 16.5 10.0 0.0035 16.5 6.9 7.7 6 2 2 8 8 8 2 Growth-arrest specific micro-tubule binding SlyX PF04102.7 CCF36012.1 - 0.011 16.1 3.8 0.011 16.1 2.6 11.7 10 4 3 14 14 14 0 SlyX DUF1751 PF08551.5 CCF36014.1 - 0.0049 17.1 0.0 0.0069 16.6 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) CTDII PF01556.13 CCF36015.1 - 8.8e-29 99.2 1.9 1e-22 79.7 0.2 3.4 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ PF00226.26 CCF36015.1 - 7.4e-24 83.2 1.3 1.3e-23 82.4 0.9 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 CCF36015.1 - 8.3e-11 41.7 21.1 1.7e-10 40.8 14.7 1.5 1 0 0 1 1 1 1 DnaJ central domain SAP30_Sin3_bdg PF13867.1 CCF36016.1 - 1.2e-13 50.7 1.2 5.1e-12 45.4 0.2 2.3 2 0 0 2 2 2 1 Sin3 binding region of histone deacetylase complex subunit SAP30 PPP5 PF08321.7 CCF36016.1 - 0.062 13.3 0.1 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 PPP5 TPR repeat region TMEM191C PF15194.1 CCF36016.1 - 0.079 12.8 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 TMEM191C family Glyco_trans_2_3 PF13632.1 CCF36018.1 - 3.6e-12 46.4 0.4 9.2e-12 45.0 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.21 CCF36018.1 - 3.1e-05 23.7 0.0 0.00037 20.2 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 CCF36018.1 - 0.019 14.7 0.0 0.26 11.0 0.0 2.2 2 0 0 2 2 2 0 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 CCF36018.1 - 0.082 12.1 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 21 ORC2 PF04084.9 CCF36019.1 - 1.6e-98 329.6 0.0 1.8e-98 329.4 0.0 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 2 NTP_transf_3 PF12804.2 CCF36019.1 - 0.0056 16.7 0.7 0.0096 16.0 0.5 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain CTP_transf_1 PF01148.15 CCF36020.1 - 2.1e-06 27.5 9.3 2.1e-06 27.5 6.4 3.3 3 1 0 3 3 3 1 Cytidylyltransferase family TGT PF01702.13 CCF36021.1 - 1.9e-28 99.3 0.0 2.3e-28 99.0 0.0 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase NDUFA12 PF05071.11 CCF36022.1 - 6.6e-28 97.2 1.4 8.6e-28 96.8 0.9 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 PLDc_2 PF13091.1 CCF36023.1 - 7.7e-14 51.5 0.0 7e-07 29.0 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.17 CCF36023.1 - 7.6e-08 31.9 2.3 0.024 14.4 0.0 3.3 2 1 0 2 2 2 2 Phospholipase D Active site motif p450 PF00067.17 CCF36025.1 - 2.7e-48 164.6 0.0 3.1e-48 164.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ribosomal_L27e PF01777.13 CCF36026.1 - 8.6e-36 121.9 4.0 1.1e-35 121.5 2.8 1.1 1 0 0 1 1 1 1 Ribosomal L27e protein family DUF1922 PF09082.5 CCF36026.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1922) KOW PF00467.24 CCF36026.1 - 0.14 11.8 1.8 0.22 11.3 0.4 2.0 2 0 0 2 2 2 0 KOW motif DUF2665 PF11654.3 CCF36027.1 - 1.4e-05 24.5 0.0 1.9e-05 24.1 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2665) DUF21 PF01595.15 CCF36027.1 - 0.059 12.6 0.0 0.062 12.5 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function DUF21 Glyoxalase PF00903.20 CCF36029.1 - 1.1e-23 83.6 0.3 2.8e-16 59.6 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.1 CCF36029.1 - 2.9e-13 49.7 0.4 3.8e-06 26.8 0.2 2.5 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 CCF36029.1 - 2.4e-11 44.1 0.1 5.3e-06 27.0 0.1 2.6 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_3 PF13468.1 CCF36029.1 - 2.4e-06 27.5 0.2 0.16 11.8 0.1 3.1 2 1 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_5 PF14696.1 CCF36029.1 - 0.0025 17.7 0.1 0.015 15.2 0.0 2.1 2 0 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal LysR_substrate PF03466.15 CCF36029.1 - 0.0074 15.4 0.0 0.011 14.7 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain YodA PF09223.6 CCF36029.1 - 0.043 13.4 0.0 0.11 12.1 0.0 1.7 1 1 0 1 1 1 0 YodA lipocalin-like domain Amidase PF01425.16 CCF36031.1 - 5.4e-90 302.3 0.0 9.4e-90 301.5 0.0 1.3 1 0 0 1 1 1 1 Amidase AHS2 PF02626.10 CCF36031.1 - 2e-83 279.8 0.0 3e-83 279.2 0.0 1.3 1 0 0 1 1 1 1 Allophanate hydrolase subunit 2 CPSase_L_D2 PF02786.12 CCF36031.1 - 1.3e-62 210.8 0.1 2.2e-62 210.1 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain AHS1 PF02682.11 CCF36031.1 - 1.8e-39 135.3 0.0 3.4e-39 134.4 0.0 1.4 1 0 0 1 1 1 1 Allophanate hydrolase subunit 1 CPSase_L_chain PF00289.17 CCF36031.1 - 5.5e-35 119.7 0.1 1.3e-34 118.6 0.1 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 CCF36031.1 - 3.5e-33 113.7 0.0 7.1e-33 112.7 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain ATP-grasp_4 PF13535.1 CCF36031.1 - 2.4e-13 50.2 0.1 5.2e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 CCF36031.1 - 3.4e-10 39.6 0.0 5.8e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl PF00364.17 CCF36031.1 - 3.8e-10 39.2 1.0 9.5e-10 37.9 0.7 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 CCF36031.1 - 1.1e-08 34.2 0.0 7.9e-05 21.5 0.0 2.4 3 0 0 3 3 3 2 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl_2 PF13533.1 CCF36031.1 - 8.9e-05 22.0 0.0 0.31 10.7 0.1 3.0 1 1 1 2 2 2 2 Biotin-lipoyl like RimK PF08443.6 CCF36031.1 - 0.00043 19.8 0.0 0.0011 18.4 0.0 1.7 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp PF02222.17 CCF36031.1 - 0.0013 18.1 0.0 0.0028 17.0 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain GCV_H PF01597.14 CCF36031.1 - 0.068 12.8 0.1 0.15 11.7 0.1 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein ATP-grasp_5 PF13549.1 CCF36031.1 - 0.18 10.9 0.0 0.6 9.2 0.0 1.8 2 0 0 2 2 2 0 ATP-grasp domain C2 PF00168.25 CCF36034.1 - 1.7e-12 46.9 0.0 0.00025 20.8 0.0 3.6 2 1 0 2 2 2 2 C2 domain MFS_1 PF07690.11 CCF36035.1 - 3.1e-23 82.0 28.2 3.1e-23 82.0 19.5 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Vma12 PF11712.3 CCF36035.1 - 6.5 6.4 9.4 4.9 6.8 0.1 3.1 3 0 0 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase IBR PF01485.16 CCF36037.1 - 5.7e-16 58.1 56.9 3.8e-09 36.2 5.4 4.9 4 1 0 4 4 4 3 IBR domain zf-RING_2 PF13639.1 CCF36037.1 - 0.0033 17.2 8.4 0.0033 17.2 5.8 4.6 3 2 1 4 4 4 1 Ring finger domain zf-C3HC4 PF00097.20 CCF36037.1 - 0.0047 16.5 7.0 0.0047 16.5 4.8 5.0 4 2 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CCF36037.1 - 0.022 14.7 8.4 0.022 14.7 5.8 6.0 4 3 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) Sterol_MT_C PF08498.5 CCF36038.1 - 9.5e-25 86.3 0.6 2e-24 85.2 0.4 1.6 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.7 CCF36038.1 - 1.7e-23 82.8 0.0 4e-23 81.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF36038.1 - 6.7e-20 71.2 0.0 1e-19 70.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF36038.1 - 5.3e-18 65.2 0.0 1.2e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF36038.1 - 7.8e-18 64.6 0.0 1.6e-17 63.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF36038.1 - 2.1e-14 53.1 0.0 3.6e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.15 CCF36038.1 - 1.2e-13 50.8 0.2 1.8e-13 50.2 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.7 CCF36038.1 - 1.6e-12 47.7 0.1 4.6e-12 46.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF36038.1 - 4.3e-12 46.5 0.0 1.3e-11 45.1 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF36038.1 - 3.4e-11 43.1 0.0 1.6e-10 40.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 CCF36038.1 - 6.7e-07 28.8 0.0 1.2e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 CCF36038.1 - 8.6e-06 25.0 0.3 4.3e-05 22.7 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.5 CCF36038.1 - 8.5e-05 22.1 0.0 0.00012 21.6 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PCMT PF01135.14 CCF36038.1 - 0.00012 21.7 0.1 0.00044 19.8 0.1 1.8 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.15 CCF36038.1 - 0.00026 20.0 0.0 0.00046 19.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_8 PF05148.10 CCF36038.1 - 0.001 18.7 0.0 0.0044 16.6 0.0 1.9 1 1 0 1 1 1 1 Hypothetical methyltransferase Pox_MCEL PF03291.11 CCF36038.1 - 0.0017 17.3 0.7 0.0097 14.7 0.0 2.0 2 0 0 2 2 2 1 mRNA capping enzyme UPF0020 PF01170.13 CCF36038.1 - 0.0018 17.8 0.0 0.0035 16.9 0.0 1.5 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_32 PF13679.1 CCF36038.1 - 0.0027 17.4 0.5 0.0047 16.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain TehB PF03848.9 CCF36038.1 - 0.01 15.0 0.0 0.016 14.3 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB MetW PF07021.7 CCF36038.1 - 0.017 14.4 0.0 0.031 13.6 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW CTI PF06934.6 CCF36038.1 - 0.02 13.1 0.1 0.029 12.6 0.1 1.1 1 0 0 1 1 1 0 Fatty acid cis/trans isomerase (CTI) DUF1642 PF07852.6 CCF36038.1 - 0.043 14.1 0.6 0.13 12.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1642) LrgB PF04172.11 CCF36039.1 - 5.9e-15 55.0 6.9 5.9e-09 35.3 0.1 2.9 3 0 0 3 3 3 2 LrgB-like family DCA16 PF15349.1 CCF36039.1 - 0.04 13.2 0.0 0.068 12.5 0.0 1.3 1 0 0 1 1 1 0 DDB1- and CUL4-associated factor 16 HAUS-augmin3 PF14932.1 CCF36040.1 - 0.14 11.2 17.4 0.11 11.7 7.8 2.7 1 1 1 3 3 3 0 HAUS augmin-like complex subunit 3 Allexi_40kDa PF05549.6 CCF36040.1 - 0.38 10.0 11.6 0.42 9.8 4.3 2.1 1 1 1 2 2 2 0 Allexivirus 40kDa protein DUF4061 PF13270.1 CCF36040.1 - 0.62 10.1 10.0 0.057 13.5 2.3 2.7 2 1 2 4 4 4 0 Domain of unknown function (DUF4061) DUF4297 PF14130.1 CCF36040.1 - 0.69 9.8 8.7 4.5 7.1 3.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4297) Glyco_hydro_67N PF03648.9 CCF36040.1 - 0.82 9.7 3.7 1.9 8.5 0.6 2.5 2 1 0 2 2 2 0 Glycosyl hydrolase family 67 N-terminus DivIC PF04977.10 CCF36040.1 - 1.3 8.5 5.3 2.2 7.7 2.0 2.3 1 1 2 3 3 3 0 Septum formation initiator SCAN PF02023.12 CCF36040.1 - 2.2 7.8 5.9 0.47 9.9 0.1 2.6 3 0 0 3 3 3 0 SCAN domain DUF2664 PF10867.3 CCF36040.1 - 2.2 8.9 9.8 1.2 9.7 2.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2664) Phage_Gp23 PF10669.4 CCF36040.1 - 3.1 7.9 10.1 5.4 7.1 3.2 2.6 1 1 1 2 2 2 0 Protein gp23 (Bacteriophage A118) BLOC1_2 PF10046.4 CCF36040.1 - 4.2 7.5 10.6 1.5 8.9 2.0 3.1 2 2 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF948 PF06103.6 CCF36040.1 - 6.2 6.7 9.0 8.6 6.3 3.3 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) SNARE PF05739.14 CCF36041.1 - 0.009 15.6 0.9 0.018 14.7 0.6 1.7 1 1 0 1 1 1 1 SNARE domain Aminotran_1_2 PF00155.16 CCF36042.1 - 3e-88 296.2 0.0 3.4e-88 296.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Myb_DNA-binding PF00249.26 CCF36042.1 - 0.055 13.5 0.0 13 5.9 0.0 2.4 2 0 0 2 2 2 0 Myb-like DNA-binding domain PAXIP1_C PF15364.1 CCF36043.1 - 0.16 11.8 4.3 0.44 10.4 3.0 1.8 1 0 0 1 1 1 0 PAXIP1-associated-protein-1 C term PTIP binding protein PGP_phosphatase PF09419.5 CCF36044.1 - 6.2e-65 217.6 0.0 7.2e-65 217.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.1 CCF36044.1 - 0.0001 21.9 0.0 0.00027 20.5 0.0 1.8 1 1 0 1 1 1 1 HAD-hyrolase-like MTHFR PF02219.12 CCF36044.1 - 0.0025 16.9 0.0 0.0033 16.5 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase PBP1_TM PF14812.1 CCF36045.1 - 0.93 9.8 16.5 0.95 9.8 3.6 2.9 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal HCaRG PF07258.9 CCF36046.1 - 0.059 12.9 0.1 2.8 7.4 0.0 2.0 1 1 1 2 2 2 0 HCaRG protein Cid2 PF09774.4 CCF36047.1 - 9.8e-48 162.0 0.0 1.2e-47 161.8 0.0 1.1 1 0 0 1 1 1 1 Caffeine-induced death protein 2 NARP1 PF12569.3 CCF36048.1 - 9.9e-194 644.8 25.2 1.1e-192 641.4 11.7 2.4 2 1 1 3 3 3 2 NMDA receptor-regulated protein 1 TPR_19 PF14559.1 CCF36048.1 - 1.4e-21 76.6 23.5 8.7e-06 25.9 1.8 7.6 5 3 2 7 7 7 4 Tetratricopeptide repeat TPR_11 PF13414.1 CCF36048.1 - 4.3e-17 61.5 21.9 3.5e-05 23.3 0.2 6.6 7 0 0 7 7 6 5 TPR repeat TPR_16 PF13432.1 CCF36048.1 - 5.6e-15 55.5 37.5 0.0013 19.3 0.4 9.3 7 2 5 12 12 10 6 Tetratricopeptide repeat TPR_2 PF07719.12 CCF36048.1 - 1.2e-13 49.7 36.5 0.00014 21.5 0.2 10.7 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_14 PF13428.1 CCF36048.1 - 1.4e-12 47.0 25.3 0.0021 18.5 0.0 10.7 7 4 6 13 13 10 4 Tetratricopeptide repeat TPR_9 PF13371.1 CCF36048.1 - 1.3e-11 44.1 9.9 0.00027 20.7 0.2 6.2 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.1 CCF36048.1 - 6e-11 42.1 26.4 0.0089 15.9 0.2 8.3 5 2 4 9 9 9 3 Tetratricopeptide repeat TPR_17 PF13431.1 CCF36048.1 - 4.1e-10 39.0 5.1 0.41 10.9 0.0 7.7 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_1 PF00515.23 CCF36048.1 - 1.6e-09 36.9 19.3 1.6e-05 24.2 0.4 7.7 7 0 0 7 7 7 3 Tetratricopeptide repeat Apc3 PF12895.2 CCF36048.1 - 7.6e-09 35.5 17.3 0.00023 21.2 1.1 5.3 4 1 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 CCF36048.1 - 1.8e-07 30.4 6.1 0.0036 16.9 0.1 6.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.1 CCF36048.1 - 0.0029 17.2 9.1 3.8 7.5 0.0 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_3 PF07720.7 CCF36048.1 - 0.033 13.9 3.8 0.14 11.9 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.9 CCF36048.1 - 0.19 12.2 17.2 4.5 7.9 0.4 7.0 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_10 PF13374.1 CCF36048.1 - 0.23 11.4 14.3 7.1 6.7 0.0 6.8 8 0 0 8 8 6 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CCF36048.1 - 0.44 10.4 16.5 6.7 6.6 0.0 5.7 6 0 0 6 6 5 0 Fis1 C-terminal tetratricopeptide repeat Sel1 PF08238.7 CCF36048.1 - 3.8 8.2 9.2 11 6.7 0.0 4.0 4 0 0 4 4 3 0 Sel1 repeat Ribosomal_L19e PF01280.15 CCF36049.1 - 1.2e-60 203.5 8.1 1.2e-60 203.5 5.6 1.6 2 0 0 2 2 2 1 Ribosomal protein L19e RNase_H2-Ydr279 PF09468.5 CCF36049.1 - 0.029 13.5 0.7 0.034 13.3 0.5 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) HEAT_EZ PF13513.1 CCF36050.1 - 7.7e-15 54.8 24.6 0.024 15.1 0.4 10.1 8 2 3 11 11 11 5 HEAT-like repeat HEAT_2 PF13646.1 CCF36050.1 - 6.5e-14 51.9 17.3 4e-07 30.2 2.3 6.0 3 2 4 7 7 7 4 HEAT repeats HEAT PF02985.17 CCF36050.1 - 8.3e-14 50.3 14.3 0.015 15.2 0.1 10.0 11 0 0 11 11 9 3 HEAT repeat ParcG PF10274.4 CCF36050.1 - 3.1e-09 36.9 0.7 8.1e-05 22.6 0.0 3.5 2 2 2 4 4 4 2 Parkin co-regulated protein CLASP_N PF12348.3 CCF36050.1 - 3.3e-08 33.1 0.1 9.2e-05 21.8 0.0 3.1 2 1 1 3 3 3 2 CLASP N terminal Cnd1 PF12717.2 CCF36050.1 - 2.1e-06 27.7 3.1 0.13 12.1 0.1 4.9 3 2 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.2 CCF36050.1 - 2.3e-06 27.9 1.4 0.34 11.3 0.0 4.9 5 2 0 5 5 5 1 Vacuolar 14 Fab1-binding region Ipi1_N PF12333.3 CCF36050.1 - 4.1e-05 23.4 0.6 0.0034 17.3 0.0 3.8 4 0 0 4 4 4 1 Rix1 complex component involved in 60S ribosome maturation UME PF08064.8 CCF36050.1 - 0.0035 17.2 0.3 8.6 6.3 0.0 4.1 3 2 1 4 4 4 1 UME (NUC010) domain TFCD_C PF12612.3 CCF36050.1 - 0.0076 15.7 3.6 0.073 12.4 0.8 3.6 2 2 1 3 3 3 1 Tubulin folding cofactor D C terminal MMS19_C PF12460.3 CCF36050.1 - 0.034 12.8 10.5 0.39 9.3 0.2 4.2 3 2 1 4 4 4 0 RNAPII transcription regulator C-terminal HEAT_PBS PF03130.11 CCF36050.1 - 0.053 13.9 0.9 32 5.3 0.1 3.8 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat U3snoRNP10 PF12397.3 CCF36050.1 - 2.7 7.9 8.0 25 4.8 0.0 4.6 3 2 2 6 6 6 0 U3 small nucleolar RNA-associated protein 10 Zn_clus PF00172.13 CCF36052.1 - 2.2e-08 33.8 9.0 3.2e-08 33.3 6.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF36052.1 - 9.4e-05 21.1 0.4 0.00018 20.2 0.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain RTA1 PF04479.8 CCF36053.1 - 2.4e-58 197.3 5.4 3.9e-58 196.6 3.7 1.3 1 0 0 1 1 1 1 RTA1 like protein DctQ PF04290.7 CCF36053.1 - 1.1 9.0 13.8 0.35 10.6 0.5 2.7 3 0 0 3 3 3 0 Tripartite ATP-independent periplasmic transporters, DctQ component Glyco_hydro_3 PF00933.16 CCF36054.1 - 6.7e-28 97.5 0.0 7.6e-28 97.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain p450 PF00067.17 CCF36055.1 - 1.3e-50 172.2 0.0 2.2e-50 171.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 DASH_Ask1 PF08655.5 CCF36057.1 - 3e-33 113.4 0.1 5.1e-33 112.6 0.1 1.4 1 0 0 1 1 1 1 DASH complex subunit Ask1 YqfQ PF14181.1 CCF36057.1 - 0.018 15.1 0.0 0.046 13.7 0.0 1.7 1 0 0 1 1 1 0 YqfQ-like protein DUF3073 PF11273.3 CCF36057.1 - 0.86 10.1 4.5 0.7 10.4 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3073) Spc97_Spc98 PF04130.8 CCF36058.1 - 4.7e-75 252.9 0.0 5.6e-75 252.6 0.0 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family Eaf7 PF07904.8 CCF36059.1 - 2.2e-26 91.6 0.2 2.2e-26 91.6 0.1 2.3 2 1 0 2 2 2 1 Chromatin modification-related protein EAF7 Nop14 PF04147.7 CCF36059.1 - 0.038 11.9 44.8 0.058 11.3 31.1 1.3 1 0 0 1 1 1 0 Nop14-like family CDC27 PF09507.5 CCF36059.1 - 0.23 10.6 40.8 0.38 9.9 28.3 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Bromodomain PF00439.20 CCF36060.1 - 1.2e-19 70.0 2.2 1.2e-19 69.9 0.1 2.1 2 0 0 2 2 2 1 Bromodomain Bromo_TP PF07524.8 CCF36060.1 - 1.8e-08 34.0 0.0 4.3e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 Bromodomain associated Glyco_tranf_2_5 PF13712.1 CCF36060.1 - 0.36 10.0 3.3 8 5.6 0.1 2.8 3 0 0 3 3 3 0 Glycosyltransferase like family ArfGap PF01412.13 CCF36062.1 - 2.6e-32 111.0 0.2 5e-32 110.1 0.1 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf ETF PF01012.16 CCF36063.1 - 3.1e-36 124.5 0.2 3.9e-36 124.2 0.2 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain PEP_mutase PF13714.1 CCF36064.1 - 1.3e-51 175.0 1.5 1.5e-51 174.8 1.1 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.16 CCF36064.1 - 8.8e-21 73.6 0.9 1.2e-20 73.2 0.6 1.1 1 0 0 1 1 1 1 Isocitrate lyase family Usp PF00582.21 CCF36065.1 - 4.6e-15 56.0 0.0 1.2e-14 54.7 0.0 1.7 1 0 0 1 1 1 1 Universal stress protein family DUF3326 PF11805.3 CCF36065.1 - 0.051 12.2 0.2 0.083 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3326) DUF3246 PF11596.3 CCF36065.1 - 3.5 6.8 11.7 14 4.9 8.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3246) ABA_GPCR PF12430.3 CCF36066.1 - 1.8e-55 187.1 0.1 5.3e-54 182.3 0.0 2.1 2 0 0 2 2 2 2 Abscisic acid G-protein coupled receptor DUF3735 PF12537.3 CCF36066.1 - 1.8e-20 72.7 0.0 2.4e-19 69.1 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3735) Transp_cyt_pur PF02133.10 CCF36068.1 - 9e-72 242.0 32.3 1e-71 241.8 22.4 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Glyco_hydro_2_C PF02836.12 CCF36069.1 - 1.6e-91 306.3 0.1 2.1e-91 305.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Bgal_small_N PF02929.12 CCF36069.1 - 6.2e-56 189.4 0.0 9.9e-56 188.7 0.0 1.3 1 0 0 1 1 1 1 Beta galactosidase small chain Glyco_hydro_2_N PF02837.13 CCF36069.1 - 1.1e-54 184.5 1.9 2e-54 183.6 1.3 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.16 CCF36069.1 - 2.3e-09 37.6 0.0 6.3e-09 36.2 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_72 PF03198.9 CCF36069.1 - 0.00024 20.2 0.7 0.002 17.1 0.0 2.2 2 0 0 2 2 2 1 Glucanosyltransferase TFIID_20kDa PF03847.8 CCF36070.1 - 3.1e-18 65.8 0.1 6.8e-18 64.7 0.0 1.6 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.18 CCF36070.1 - 0.013 15.4 0.4 0.13 12.2 0.0 2.6 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Arb1 PF09692.5 CCF36071.1 - 2.1e-92 309.9 0.0 2.5e-92 309.7 0.0 1.0 1 0 0 1 1 1 1 Argonaute siRNA chaperone (ARC) complex subunit Arb1 Pmp3 PF01679.12 CCF36072.1 - 2.8e-20 71.7 6.1 3.5e-20 71.4 4.2 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator adh_short_C2 PF13561.1 CCF36073.1 - 0.0028 17.4 0.0 0.0032 17.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Sugar_tr PF00083.19 CCF36074.1 - 1.5e-107 360.0 24.1 2e-107 359.5 16.7 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF36074.1 - 2.3e-20 72.6 25.4 2.3e-20 72.6 17.6 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Med25_SD1 PF11235.3 CCF36075.1 - 0.0077 16.5 3.0 0.0079 16.5 2.1 1.1 1 0 0 1 1 1 1 Mediator complex subunit 25 synapsin 1 Glyco_hydro_71 PF03659.9 CCF36076.1 - 1.1e-54 185.3 0.1 1.2e-54 185.2 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 FAD_binding_4 PF01565.18 CCF36077.1 - 1e-18 67.1 1.6 1.2e-18 66.8 0.3 1.8 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.7 CCF36077.1 - 3e-08 33.4 0.7 6.9e-08 32.2 0.5 1.6 1 0 0 1 1 1 1 Berberine and berberine like SPX PF03105.14 CCF36078.1 - 1.4e-48 166.0 0.0 2.6e-48 165.2 0.0 1.4 1 1 0 1 1 1 1 SPX domain Na_sulph_symp PF00939.14 CCF36078.1 - 2.1e-36 125.8 41.6 3e-36 125.2 28.8 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 CCF36078.1 - 4.4e-12 45.2 54.8 1.6e-11 43.3 22.6 2.8 1 1 2 3 3 3 3 Citrate transporter Sporozoite_P67 PF05642.6 CCF36078.1 - 0.37 8.5 7.7 1.3 6.7 5.1 1.8 1 1 0 1 1 1 0 Sporozoite P67 surface antigen Vps39_1 PF10366.4 CCF36079.1 - 4.3e-34 116.7 0.0 5.4e-33 113.2 0.0 2.9 4 0 0 4 4 4 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.4 CCF36079.1 - 3.4e-31 107.6 0.0 1.1e-30 106.0 0.0 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.17 CCF36079.1 - 2.3e-20 73.1 0.0 5.1e-20 72.0 0.0 1.5 1 1 0 1 1 1 1 CNH domain Clathrin PF00637.15 CCF36079.1 - 5.9e-06 25.9 0.9 0.00062 19.3 0.6 2.9 3 0 0 3 3 3 1 Region in Clathrin and VPS TPR_16 PF13432.1 CCF36079.1 - 0.03 14.9 0.3 4.9 7.9 0.0 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 CCF36079.1 - 0.1 12.9 1.1 20 5.6 0.0 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 CCF36079.1 - 0.11 12.2 0.6 38 4.0 0.2 4.0 3 1 1 4 4 4 0 TPR repeat TPR_1 PF00515.23 CCF36079.1 - 0.28 10.8 4.6 0.67 9.6 0.4 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Gon7 PF08738.5 CCF36080.1 - 1.8e-12 47.1 6.1 1.3e-11 44.4 0.8 2.1 1 1 1 2 2 2 2 Gon7 family HbrB PF08539.6 CCF36081.1 - 3.4e-55 186.2 0.0 5e-55 185.6 0.0 1.3 1 0 0 1 1 1 1 HbrB-like MFS_1 PF07690.11 CCF36082.1 - 2.8e-30 105.2 30.1 2.8e-30 105.2 20.9 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF36082.1 - 1.4e-11 43.7 18.6 2.3e-11 42.9 12.9 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter ATG22 PF11700.3 CCF36082.1 - 8.9e-06 24.4 6.6 8.9e-06 24.4 4.6 2.7 1 1 0 2 2 2 1 Vacuole effluxer Atg22 like TRI12 PF06609.8 CCF36082.1 - 0.0026 16.0 0.6 0.0026 16.0 0.4 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Na_K-ATPase PF00287.13 CCF36082.1 - 0.23 10.2 0.1 0.44 9.2 0.1 1.4 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain Mito_carr PF00153.22 CCF36084.1 - 6e-44 147.6 6.8 6.1e-17 61.1 0.1 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF2293 PF10056.4 CCF36085.1 - 3.2e-28 97.5 0.5 3.2e-28 97.5 0.3 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2293) DRMBL PF07522.9 CCF36086.1 - 3.7e-07 30.1 0.0 1.3e-06 28.4 0.0 1.9 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.2 CCF36086.1 - 0.0025 17.4 0.0 0.0055 16.2 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain RMMBL PF07521.7 CCF36086.1 - 0.01 15.6 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 0 RNA-metabolising metallo-beta-lactamase MFS_1 PF07690.11 CCF36087.1 - 1.1e-12 47.4 33.6 1.1e-12 47.4 23.3 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Polysacc_deac_1 PF01522.16 CCF36088.1 - 3.6e-21 75.0 0.0 4.7e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase UPF0118 PF01594.11 CCF36088.1 - 0.0075 15.2 0.0 0.01 14.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function DUF20 DNA_pol_B_thumb PF14791.1 CCF36088.1 - 0.041 13.5 0.0 0.96 9.1 0.0 2.3 2 0 0 2 2 2 0 DNA polymerase beta thumb TFIIA PF03153.8 CCF36089.1 - 9.8 5.9 9.7 14 5.4 6.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Helicase_C PF00271.26 CCF36092.1 - 7.5e-20 70.5 0.0 1.1e-16 60.3 0.0 2.4 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.24 CCF36092.1 - 1.8e-16 60.1 0.0 3.2e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase SNF2_N PF00176.18 CCF36092.1 - 0.099 11.4 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain RNase_H2_suC PF08615.6 CCF36093.1 - 8.8e-26 90.3 0.0 1.1e-25 90.0 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) MCM PF00493.18 CCF36094.1 - 5e-136 452.8 0.3 8.8e-136 452.0 0.2 1.4 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 CCF36094.1 - 4.3e-20 72.4 0.3 6.2e-19 68.6 0.0 2.8 3 1 0 3 3 3 1 MCM N-terminal domain Mg_chelatase PF01078.16 CCF36094.1 - 2.2e-07 30.2 0.0 8.8e-07 28.2 0.0 2.0 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 CCF36094.1 - 0.00092 18.7 0.0 0.002 17.6 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.6 CCF36094.1 - 0.0024 17.4 0.0 0.007 15.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CCF36094.1 - 0.045 13.4 0.0 0.13 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) KOW PF00467.24 CCF36095.1 - 1.1e-07 31.3 2.8 1.1e-07 31.3 1.9 2.0 2 0 0 2 2 2 1 KOW motif DUF2950 PF11453.3 CCF36096.1 - 0.076 11.9 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2950) GMC_oxred_N PF00732.14 CCF36097.1 - 4.1e-45 154.1 0.0 5.1e-45 153.8 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 CCF36097.1 - 4.7e-06 25.7 0.1 6.5e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF36097.1 - 6.9e-06 25.9 0.0 1.9e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CCF36097.1 - 0.0041 16.0 0.0 0.0057 15.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 CCF36097.1 - 0.0071 15.4 0.1 0.0071 15.4 0.0 1.5 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.9 CCF36097.1 - 0.018 13.5 0.0 0.022 13.2 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_2 PF07992.9 CCF36097.1 - 0.023 14.5 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF36097.1 - 0.033 13.9 0.1 0.051 13.3 0.1 1.3 1 0 0 1 1 1 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.7 CCF36097.1 - 0.052 12.4 0.1 0.072 12.0 0.0 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox PF00070.22 CCF36097.1 - 0.066 13.6 0.2 0.13 12.6 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF36097.1 - 0.13 10.8 0.0 0.19 10.2 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase TrkA_N PF02254.13 CCF36097.1 - 0.16 11.9 0.2 0.31 11.0 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain Radical_SAM PF04055.16 CCF36098.1 - 7.7e-09 35.9 0.0 1.2e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.1 CCF36098.1 - 6.4e-07 29.5 0.0 1.2e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.1 CCF36098.1 - 0.00064 19.7 0.1 0.0015 18.5 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain XPG_I_2 PF12813.2 CCF36099.1 - 0.13 11.6 0.2 0.19 11.1 0.2 1.2 1 0 0 1 1 1 0 XPG domain containing DUF3328 PF11807.3 CCF36100.1 - 6.1e-42 143.7 0.1 7.5e-42 143.4 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) TM231 PF10149.4 CCF36100.1 - 0.033 13.1 0.0 0.047 12.6 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 231 Nop10p PF04135.7 CCF36101.1 - 3.4e-21 74.7 0.0 4e-21 74.4 0.0 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family NOB1_Zn_bind PF08772.6 CCF36102.1 - 1.5e-31 107.9 4.4 2.6e-31 107.2 3.1 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like UPF0278 PF08745.6 CCF36102.1 - 0.023 13.9 0.6 3.8 6.7 0.0 3.0 2 1 1 3 3 3 0 UPF0278 family AF1Q PF15017.1 CCF36102.1 - 0.36 10.7 8.5 1.2 9.0 5.1 2.4 1 1 0 1 1 1 0 Drug resistance and apoptosis regulator Zn_clus PF00172.13 CCF36103.1 - 4.5e-19 68.0 27.0 1.7e-10 40.6 4.8 2.5 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF36103.1 - 3e-13 49.2 0.2 4.6e-13 48.6 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain ApoB100_C PF12491.3 CCF36103.1 - 0.0088 15.6 0.2 1.4 8.6 0.0 2.4 2 0 0 2 2 2 2 Apolipoprotein B100 C terminal GFA PF04828.9 CCF36104.1 - 1.9e-12 46.9 0.6 4e-06 26.6 1.1 2.2 2 0 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme Oest_recep PF02159.10 CCF36105.1 - 0.048 13.7 1.0 0.061 13.4 0.7 1.1 1 0 0 1 1 1 0 Oestrogen receptor Glutaredoxin PF00462.19 CCF36106.1 - 2e-13 50.1 0.1 1.4e-12 47.4 0.0 2.4 2 0 0 2 2 2 1 Glutaredoxin Med16 PF11635.3 CCF36107.1 - 4e-118 395.4 0.0 5.1e-118 395.0 0.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 RhoGEF PF00621.15 CCF36108.1 - 2.9e-27 95.6 0.0 5.4e-27 94.8 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain DUF3507 PF12015.3 CCF36108.1 - 0.13 11.7 0.0 0.25 10.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3507) EST1_DNA_bind PF10373.4 CCF36108.1 - 0.15 11.2 0.0 0.37 9.9 0.0 1.6 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain DUF2036 PF09724.4 CCF36109.1 - 1e-05 24.8 0.0 1.1e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2036) FAD_binding_1 PF00667.15 CCF36110.1 - 0.16 11.4 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain F-box-like PF12937.2 CCF36113.1 - 0.00048 19.7 0.0 0.0013 18.3 0.0 1.8 1 0 0 1 1 1 1 F-box-like Fungal_trans PF04082.13 CCF36114.1 - 1.1e-25 89.9 0.5 1.7e-25 89.3 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF36114.1 - 6.1e-08 32.4 8.9 1.1e-07 31.5 6.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.19 CCF36115.1 - 1.4e-96 323.8 16.5 1.5e-96 323.6 11.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF36115.1 - 2.2e-33 115.4 27.2 9.3e-25 87.0 5.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Shisa PF13908.1 CCF36116.1 - 0.0051 17.0 0.0 0.0051 17.0 0.0 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF1183 PF06682.7 CCF36116.1 - 0.0071 15.9 0.1 0.0077 15.8 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1183) Adeno_E3_CR2 PF02439.10 CCF36116.1 - 0.025 14.1 3.6 0.039 13.5 2.5 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 CD34_antigen PF06365.7 CCF36116.1 - 0.03 13.9 0.1 0.04 13.5 0.1 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family EphA2_TM PF14575.1 CCF36116.1 - 0.07 13.5 0.0 0.094 13.1 0.0 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain IncA PF04156.9 CCF36116.1 - 0.071 12.6 0.0 0.071 12.6 0.0 1.0 1 0 0 1 1 1 0 IncA protein RCR PF12273.3 CCF36116.1 - 0.089 13.3 0.5 0.14 12.7 0.1 1.4 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red CorA PF01544.13 CCF36117.1 - 1.5e-06 27.4 0.0 2.5e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein MRC1 PF09444.5 CCF36118.1 - 6.4e-41 140.0 17.7 6.4e-41 140.0 12.3 7.9 7 2 1 8 8 8 1 MRC1-like domain Pkinase PF00069.20 CCF36120.1 - 1.5e-19 70.1 0.0 9.2e-19 67.5 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF36120.1 - 1.1e-08 34.4 0.0 0.002 17.2 0.0 2.7 4 0 0 4 4 4 2 Protein tyrosine kinase APH PF01636.18 CCF36120.1 - 5.5e-05 23.0 0.2 0.0048 16.6 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 CCF36120.1 - 0.029 13.3 0.0 0.44 9.4 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Glyco_hydro_88 PF07470.8 CCF36121.1 - 4.4e-12 45.6 0.0 5.5e-12 45.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Sugar_tr PF00083.19 CCF36124.1 - 5e-93 312.1 27.5 6.2e-93 311.8 19.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF36124.1 - 7.1e-23 80.8 60.9 9.7e-21 73.8 18.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily AA_permease_2 PF13520.1 CCF36125.1 - 4.5e-39 134.1 51.8 5.9e-39 133.7 35.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF36125.1 - 1.3e-23 83.1 42.6 1.9e-23 82.6 29.5 1.1 1 0 0 1 1 1 1 Amino acid permease SYS1 PF09801.4 CCF36125.1 - 2.1 8.3 15.2 1 9.3 0.1 3.6 4 1 0 4 4 4 0 Integral membrane protein S linking to the trans Golgi network Raftlin PF15250.1 CCF36130.1 - 0.081 11.4 11.9 0.1 11.1 8.2 1.0 1 0 0 1 1 1 0 Raftlin CDC45 PF02724.9 CCF36130.1 - 0.13 10.2 18.6 0.15 10.0 12.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Tetraspannin PF00335.15 CCF36130.1 - 0.53 9.5 2.9 0.7 9.1 2.0 1.2 1 0 0 1 1 1 0 Tetraspanin family SR-25 PF10500.4 CCF36130.1 - 4.5 6.6 27.6 6.3 6.2 19.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Asn_synthase PF00733.16 CCF36131.1 - 8.7e-52 176.1 0.0 1.2e-51 175.6 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 CCF36131.1 - 9.5e-36 122.2 0.0 1.9e-35 121.2 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 CCF36131.1 - 3.6e-34 117.5 0.0 1.1e-33 116.0 0.0 1.8 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.3 CCF36131.1 - 1e-06 28.1 0.0 2.3e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Aluminium induced protein GATase_2 PF00310.16 CCF36131.1 - 0.0007 18.4 0.0 0.45 9.1 0.0 3.1 1 1 2 3 3 3 1 Glutamine amidotransferases class-II tRNA_Me_trans PF03054.11 CCF36131.1 - 0.004 15.7 0.0 0.0057 15.2 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.12 CCF36131.1 - 0.032 13.1 0.0 0.049 12.5 0.0 1.3 1 0 0 1 1 1 0 NAD synthase Sec10 PF07393.6 CCF36132.1 - 1.2e-31 109.6 0.0 1.5e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 MCM2_N PF12619.3 CCF36132.1 - 0.17 11.8 1.1 0.29 11.1 0.8 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance protein 2 zf-C3HC4 PF00097.20 CCF36133.1 - 6.1e-08 32.2 12.1 1.2e-07 31.2 8.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF36133.1 - 2e-07 30.5 8.0 4.6e-07 29.3 5.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF36133.1 - 2.9e-07 30.1 12.9 6.9e-07 28.9 8.9 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 CCF36133.1 - 1.9e-06 27.7 12.3 4.7e-06 26.5 8.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CCF36133.1 - 0.0026 17.5 9.7 0.0026 17.5 6.8 1.8 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 CCF36133.1 - 0.0026 17.4 10.8 0.0055 16.4 7.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.1 CCF36133.1 - 0.0063 16.0 7.2 0.015 14.9 5.0 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.1 CCF36133.1 - 0.0082 15.8 7.8 0.026 14.2 5.4 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.2 CCF36133.1 - 0.0083 16.2 11.5 0.025 14.6 8.0 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger DUF1244 PF06844.6 CCF36133.1 - 0.053 13.3 2.0 0.15 11.9 1.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1244) LacAB_rpiB PF02502.13 CCF36133.1 - 0.06 12.9 0.0 1.7 8.2 0.0 2.3 2 0 0 2 2 2 0 Ribose/Galactose Isomerase Prok-RING_4 PF14447.1 CCF36133.1 - 0.087 12.3 7.5 0.17 11.4 5.2 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 STAT1_TAZ2bind PF12162.3 CCF36133.1 - 0.17 11.3 0.2 0.39 10.1 0.2 1.6 1 0 0 1 1 1 0 STAT1 TAZ2 binding domain IBR PF01485.16 CCF36133.1 - 5.3 6.9 10.8 19 5.2 7.5 1.8 1 1 0 1 1 1 0 IBR domain zf-P11 PF03854.9 CCF36133.1 - 6 6.4 11.1 1.4 8.4 5.3 1.8 2 0 0 2 2 2 0 P-11 zinc finger Arginase PF00491.16 CCF36134.1 - 4.1e-93 311.6 0.0 4.8e-93 311.4 0.0 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.2 CCF36134.1 - 0.084 13.0 1.4 0.2 11.8 0.2 1.9 1 1 1 2 2 2 0 UPF0489 domain Ras PF00071.17 CCF36136.1 - 1.9e-52 176.9 0.0 2.2e-52 176.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF36136.1 - 5.6e-16 59.1 0.0 1.2e-15 58.0 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 CCF36136.1 - 1.3e-06 27.7 0.0 1.8e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ecl1 PF12855.2 CCF36137.1 - 9.9e-13 47.1 2.4 1.6e-12 46.4 1.7 1.3 1 0 0 1 1 1 1 Life-span regulatory factor DUF581 PF04570.9 CCF36137.1 - 0.0055 15.9 2.6 0.0098 15.1 1.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF581) zf-MYND PF01753.13 CCF36137.1 - 0.044 13.6 2.5 0.073 12.9 1.7 1.4 1 0 0 1 1 1 0 MYND finger NinG PF05766.7 CCF36137.1 - 0.17 11.5 1.8 0.25 11.0 1.3 1.2 1 0 0 1 1 1 0 Bacteriophage Lambda NinG protein C1_1 PF00130.17 CCF36137.1 - 0.28 10.9 2.2 0.44 10.3 1.5 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF329 PF03884.9 CCF36137.1 - 0.31 10.6 3.6 0.66 9.5 2.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF329) DUF2256 PF10013.4 CCF36137.1 - 7.5 6.4 6.8 1.7 8.4 0.2 2.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) DUF3757 PF12582.3 CCF36138.1 - 0.087 13.0 0.1 1.3 9.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3757) CFIA_Pcf11 PF11526.3 CCF36138.1 - 0.26 11.4 3.5 0.58 10.3 2.4 1.5 1 0 0 1 1 1 0 Subunit of cleavage factor IA Pcf11 NOA36 PF06524.7 CCF36138.1 - 3.8 6.6 10.6 5.1 6.2 7.3 1.3 1 0 0 1 1 1 0 NOA36 protein RXT2_N PF08595.6 CCF36138.1 - 4.2 7.1 6.7 6.7 6.5 4.6 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal FMN_bind_2 PF04299.7 CCF36139.1 - 3.2e-51 173.1 0.0 3.7e-51 172.9 0.0 1.1 1 0 0 1 1 1 1 Putative FMN-binding domain HET PF06985.6 CCF36141.1 - 4.1e-22 78.8 0.1 2.7e-17 63.2 0.0 2.3 2 0 0 2 2 2 2 Heterokaryon incompatibility protein (HET) Nitrate_red_gam PF02665.9 CCF36142.1 - 0.049 12.9 0.4 0.055 12.8 0.3 1.0 1 0 0 1 1 1 0 Nitrate reductase gamma subunit Col_cuticle_N PF01484.12 CCF36142.1 - 1.5 8.5 5.4 0.85 9.3 0.9 2.0 2 0 0 2 2 2 0 Nematode cuticle collagen N-terminal domain GFA PF04828.9 CCF36143.1 - 1.9e-13 50.1 0.1 1.9e-13 50.1 0.0 1.7 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme HypD PF01924.11 CCF36143.1 - 0.11 11.2 0.3 0.13 10.9 0.2 1.1 1 0 0 1 1 1 0 Hydrogenase formation hypA family Ras PF00071.17 CCF36145.1 - 1.1e-51 174.4 0.0 2e-51 173.6 0.0 1.4 1 1 0 1 1 1 1 Ras family Miro PF08477.8 CCF36145.1 - 1.3e-17 64.3 0.0 8.1e-16 58.6 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 CCF36145.1 - 0.00043 19.5 0.0 0.0015 17.7 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 CCF36145.1 - 0.014 15.3 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase Abhydrolase_4 PF08386.5 CCF36145.1 - 0.023 14.6 0.0 0.061 13.2 0.0 1.7 2 0 0 2 2 2 0 TAP-like protein FeoB_N PF02421.13 CCF36145.1 - 0.042 13.1 0.1 0.39 9.9 0.0 2.1 2 1 0 2 2 2 0 Ferrous iron transport protein B AAA_25 PF13481.1 CCF36145.1 - 0.089 12.1 0.2 0.22 10.8 0.1 1.5 1 1 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.7 CCF36145.1 - 0.097 11.7 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Pox_F11 PF04943.7 CCF36146.1 - 0.057 12.2 0.1 0.057 12.2 0.0 1.0 1 0 0 1 1 1 0 Poxvirus F11 protein HlyIII PF03006.15 CCF36147.1 - 2.1e-50 171.1 15.9 2.8e-50 170.7 11.0 1.1 1 0 0 1 1 1 1 Haemolysin-III related RhoGAP PF00620.22 CCF36151.1 - 1.6e-27 96.0 0.0 2.4e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain RRS1 PF04939.7 CCF36152.1 - 8.4e-60 200.9 6.7 9.6e-60 200.7 4.7 1.0 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) DUF1244 PF06844.6 CCF36152.1 - 2.6 7.9 5.5 0.46 10.3 1.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1244) DAP3 PF10236.4 CCF36153.1 - 1.4e-69 234.3 0.0 1.4e-68 231.1 0.0 2.0 1 1 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 MCM PF00493.18 CCF36154.1 - 2.7e-135 450.4 0.0 2.7e-135 450.4 0.0 1.5 2 0 0 2 2 2 1 MCM2/3/5 family MCM_N PF14551.1 CCF36154.1 - 2.4e-24 86.1 0.2 7.9e-24 84.4 0.1 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 CCF36154.1 - 1.4e-07 30.9 0.0 1.5e-05 24.2 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 CCF36154.1 - 4.7e-06 26.3 0.0 1.7e-05 24.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase_2 PF13335.1 CCF36154.1 - 0.017 15.4 1.3 0.052 13.9 0.1 2.5 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 CCF36154.1 - 0.018 14.6 0.0 0.065 12.8 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 CCF36154.1 - 0.12 11.8 0.0 1 8.7 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA PF00004.24 CCF36155.1 - 4.2e-54 182.2 0.0 1.9e-43 147.8 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.6 CCF36155.1 - 2e-26 91.8 0.2 1.5e-25 89.0 0.1 2.4 2 0 0 2 2 2 1 Peroxisome biogenesis factor 1, N-terminal AAA_16 PF13191.1 CCF36155.1 - 1.8e-11 44.3 5.8 1.8e-06 28.1 0.1 4.0 3 1 1 4 4 3 2 AAA ATPase domain NACHT PF05729.7 CCF36155.1 - 1.6e-07 31.1 0.2 0.0003 20.4 0.0 3.4 3 0 0 3 3 3 1 NACHT domain RuvB_N PF05496.7 CCF36155.1 - 1.1e-05 24.6 0.0 0.013 14.5 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 CCF36155.1 - 1.7e-05 24.6 0.0 0.16 11.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 CCF36155.1 - 1.8e-05 25.5 0.0 0.16 12.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 CCF36155.1 - 2.9e-05 24.2 1.1 0.43 10.7 0.1 3.5 2 2 0 2 2 2 2 AAA domain TIP49 PF06068.8 CCF36155.1 - 3.3e-05 22.7 0.0 0.059 12.0 0.0 2.3 2 0 0 2 2 2 2 TIP49 C-terminus AAA_18 PF13238.1 CCF36155.1 - 5.7e-05 23.4 0.1 0.037 14.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 CCF36155.1 - 8.2e-05 22.5 0.1 0.4 10.5 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_2 PF07724.9 CCF36155.1 - 8.8e-05 22.4 0.0 0.23 11.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 CCF36155.1 - 0.0001 22.0 0.1 0.52 10.0 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 CCF36155.1 - 0.00022 20.9 0.0 0.63 9.8 0.0 2.8 2 0 0 2 2 2 2 Part of AAA domain IstB_IS21 PF01695.12 CCF36155.1 - 0.00026 20.4 0.4 0.5 9.7 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein Zeta_toxin PF06414.7 CCF36155.1 - 0.00042 19.4 0.0 1 8.4 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin Sigma54_activ_2 PF14532.1 CCF36155.1 - 0.00057 19.9 0.0 0.19 11.7 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain UPF0079 PF02367.12 CCF36155.1 - 0.0017 17.9 0.1 0.038 13.6 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_25 PF13481.1 CCF36155.1 - 0.003 16.9 4.5 1.7 8.0 0.2 3.9 2 2 2 4 4 4 1 AAA domain RNA_helicase PF00910.17 CCF36155.1 - 0.0032 17.6 0.0 4.2 7.5 0.0 2.6 2 0 0 2 2 2 1 RNA helicase Mg_chelatase PF01078.16 CCF36155.1 - 0.0078 15.3 0.5 0.67 9.0 0.0 2.8 3 0 0 3 3 2 1 Magnesium chelatase, subunit ChlI Cytidylate_kin2 PF13189.1 CCF36155.1 - 0.011 15.6 0.0 2.1 8.2 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase-like family AAA_28 PF13521.1 CCF36155.1 - 0.012 15.5 0.1 4 7.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.13 CCF36155.1 - 0.029 13.8 0.0 3.5 7.0 0.0 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.21 CCF36155.1 - 0.03 13.8 0.0 1.8 8.0 0.0 2.6 3 0 0 3 3 2 0 Sigma-54 interaction domain SKI PF01202.17 CCF36155.1 - 0.037 13.9 0.2 5.5 6.8 0.0 2.5 2 0 0 2 2 2 0 Shikimate kinase Arch_ATPase PF01637.13 CCF36155.1 - 0.046 13.4 0.0 6.1 6.4 0.0 3.0 2 1 1 3 3 3 0 Archaeal ATPase DUF2075 PF09848.4 CCF36155.1 - 0.059 12.3 0.0 6.8 5.5 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) TIR_2 PF13676.1 CCF36155.1 - 0.073 13.2 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 TIR domain KaiC PF06745.8 CCF36155.1 - 0.075 12.1 0.0 11 5.1 0.0 2.4 2 0 0 2 2 2 0 KaiC NB-ARC PF00931.17 CCF36155.1 - 0.21 10.4 0.5 6.5 5.5 0.0 2.5 3 0 0 3 3 3 0 NB-ARC domain cobW PF02492.14 CCF36155.1 - 0.55 9.6 2.5 2.9 7.3 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RPA_C PF08784.6 CCF36157.1 - 4.9e-20 71.8 0.1 1.1e-19 70.7 0.0 1.6 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.20 CCF36157.1 - 7.8e-09 35.2 0.1 1.4e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain MarR_2 PF12802.2 CCF36157.1 - 0.14 11.8 0.0 0.36 10.5 0.0 1.7 1 0 0 1 1 1 0 MarR family Lon_C PF05362.8 CCF36158.1 - 2.2e-68 229.5 1.0 1.1e-67 227.3 0.4 2.0 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain LON PF02190.11 CCF36158.1 - 6.8e-26 91.2 0.0 1.5e-25 90.1 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent protease La (LON) domain AAA PF00004.24 CCF36158.1 - 5.3e-23 81.6 0.0 1.2e-22 80.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.1 CCF36158.1 - 2.6e-09 36.6 0.2 1.5e-08 34.1 0.0 2.3 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.9 CCF36158.1 - 1.5e-07 31.2 0.0 4.5e-07 29.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 CCF36158.1 - 2.5e-06 27.0 0.0 5.5e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.1 CCF36158.1 - 5.7e-06 26.4 0.0 1.5e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_3 PF07726.6 CCF36158.1 - 5e-05 22.9 0.0 0.00012 21.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CCF36158.1 - 0.00011 23.0 0.0 0.00041 21.1 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.9 CCF36158.1 - 0.0003 20.7 0.0 0.0014 18.5 0.0 2.1 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 CCF36158.1 - 0.00043 19.3 0.0 0.0011 18.0 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 CCF36158.1 - 0.00063 19.8 0.0 0.013 15.6 0.0 2.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CCF36158.1 - 0.0011 18.7 0.1 0.005 16.5 0.0 2.1 2 0 0 2 2 2 1 Part of AAA domain TIP49 PF06068.8 CCF36158.1 - 0.0012 17.6 0.1 0.003 16.3 0.0 1.6 2 0 0 2 2 2 1 TIP49 C-terminus AAA_23 PF13476.1 CCF36158.1 - 0.0054 17.0 7.6 0.16 12.2 0.0 3.8 3 1 1 4 4 3 1 AAA domain Zeta_toxin PF06414.7 CCF36158.1 - 0.0071 15.4 0.0 0.014 14.5 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_25 PF13481.1 CCF36158.1 - 0.0072 15.7 0.0 0.019 14.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 CCF36158.1 - 0.009 15.9 0.0 0.033 14.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 CCF36158.1 - 0.01 15.7 0.0 0.023 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 CCF36158.1 - 0.016 14.8 0.0 0.099 12.2 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.1 CCF36158.1 - 0.017 15.4 0.0 0.055 13.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 CCF36158.1 - 0.018 14.5 0.0 0.046 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 CCF36158.1 - 0.053 13.6 0.0 0.18 11.9 0.0 1.9 2 0 0 2 2 1 0 RNA helicase UPF0079 PF02367.12 CCF36158.1 - 0.061 12.9 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 DUF258 PF03193.11 CCF36158.1 - 0.099 11.8 0.0 0.21 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Exo_endo_phos PF03372.18 CCF36160.1 - 6.9e-11 42.5 0.1 1.2e-10 41.8 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 CCF36160.1 - 0.0013 18.3 0.1 0.15 11.6 0.0 3.1 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase DUF2613 PF11021.3 CCF36162.1 - 6.4 6.5 9.9 0.55 9.9 2.5 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2613) DNAPolymera_Pol PF11590.3 CCF36163.1 - 0.21 11.2 1.9 0.38 10.4 1.3 1.4 1 0 0 1 1 1 0 DNA polymerase catalytic subunit Pol MFS_1 PF07690.11 CCF36165.1 - 1.5e-42 145.6 37.0 1.5e-42 145.6 25.6 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF36165.1 - 5.2e-15 54.9 8.0 5.2e-15 54.9 5.6 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 CCF36165.1 - 1.3e-12 46.8 14.5 2e-12 46.1 10.1 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.15 CCF36165.1 - 0.039 11.9 8.3 0.084 10.9 1.5 2.3 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family HpcH_HpaI PF03328.9 CCF36166.1 - 3.3e-44 150.4 0.0 6.1e-44 149.5 0.0 1.4 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.1 CCF36166.1 - 1.3e-12 47.2 0.1 3.2e-06 26.1 0.0 2.1 2 0 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold PK PF00224.16 CCF36166.1 - 0.0037 15.9 0.0 0.0053 15.4 0.0 1.2 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PEPcase_2 PF14010.1 CCF36166.1 - 0.086 11.1 0.1 0.13 10.5 0.0 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Mg_trans_NIPA PF05653.9 CCF36168.1 - 3.8e-43 147.5 2.0 1.4e-38 132.5 0.3 2.0 2 0 0 2 2 2 2 Magnesium transporter NIPA EmrE PF13536.1 CCF36168.1 - 6e-06 26.4 1.7 6e-06 26.4 1.2 3.0 3 1 0 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 CCF36168.1 - 0.0012 18.8 2.5 0.0012 18.8 1.7 3.4 3 1 0 3 3 3 1 EamA-like transporter family DUF4231 PF14015.1 CCF36168.1 - 0.033 14.1 1.1 0.65 10.0 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF4231) DUF914 PF06027.7 CCF36168.1 - 0.034 13.0 1.3 0.087 11.6 0.1 2.0 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF914) Pox_A14 PF05767.7 CCF36168.1 - 0.11 12.4 8.5 2 8.4 1.4 2.8 2 1 1 3 3 3 0 Poxvirus virion envelope protein A14 LRR19-TM PF15176.1 CCF36168.1 - 0.19 11.4 0.0 0.19 11.4 0.0 2.3 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain ABC2_membrane_5 PF13346.1 CCF36168.1 - 0.73 9.0 6.2 0.053 12.8 0.8 1.6 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF805 PF05656.9 CCF36168.1 - 1.4 8.7 5.2 4 7.2 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF805) SLAC1 PF03595.12 CCF36169.1 - 1.2e-77 260.7 49.9 1.4e-77 260.5 34.6 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel CAP_N PF01213.14 CCF36170.1 - 1.1 8.4 4.4 1 8.5 3.1 1.0 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Actin PF00022.14 CCF36171.1 - 2.1e-14 52.7 0.0 5.7e-13 48.0 0.0 2.0 2 0 0 2 2 2 2 Actin Borrelia_P83 PF05262.6 CCF36171.1 - 1 7.5 3.1 1.5 7.0 2.2 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF500 PF04366.7 CCF36172.1 - 3.2e-26 91.2 0.0 6.9e-26 90.1 0.0 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF500) Cwf_Cwc_15 PF04889.7 CCF36172.1 - 1.6 8.3 9.2 3.8 7.1 6.3 1.6 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Acyl_transf_3 PF01757.17 CCF36173.1 - 1.6e-22 79.8 32.1 3.4e-22 78.7 22.2 1.5 1 1 0 1 1 1 1 Acyltransferase family Gtr1_RagA PF04670.7 CCF36174.1 - 3.4e-93 311.0 0.0 4.4e-93 310.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.17 CCF36174.1 - 1.7e-07 30.7 0.1 3.4e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Ras family Arf PF00025.16 CCF36174.1 - 1.2e-06 27.8 0.0 1.9e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 CCF36174.1 - 2e-05 24.5 0.0 3.5e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CCF36174.1 - 0.00013 22.4 0.0 0.00026 21.4 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein AAA_29 PF13555.1 CCF36174.1 - 0.00087 18.7 1.0 0.0068 15.9 0.2 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC_tran PF00005.22 CCF36174.1 - 0.0029 17.9 0.3 0.012 15.9 0.0 2.1 2 1 0 2 2 2 1 ABC transporter DUF815 PF05673.8 CCF36174.1 - 0.02 13.7 0.1 0.048 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) G-alpha PF00503.15 CCF36174.1 - 0.025 13.2 0.2 0.72 8.4 0.0 2.4 2 0 0 2 2 2 0 G-protein alpha subunit AAA_10 PF12846.2 CCF36174.1 - 0.047 13.1 0.0 0.084 12.3 0.0 1.4 1 1 0 1 1 1 0 AAA-like domain DUF258 PF03193.11 CCF36174.1 - 0.061 12.5 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 SEP PF08059.8 CCF36175.1 - 3.2e-26 91.4 0.0 6.7e-26 90.4 0.0 1.5 1 0 0 1 1 1 1 SEP domain UBX PF00789.15 CCF36175.1 - 1.1e-11 44.6 0.0 1.8e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.1 CCF36175.1 - 6.4e-11 41.6 0.1 1.1e-10 40.8 0.1 1.4 1 0 0 1 1 1 1 UBA-like domain UBA PF00627.26 CCF36175.1 - 0.11 12.3 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 UBA/TS-N domain TOM13 PF08219.6 CCF36176.1 - 6.6e-30 102.7 0.0 8.3e-30 102.3 0.0 1.1 1 0 0 1 1 1 1 Outer membrane protein TOM13 p450 PF00067.17 CCF36177.1 - 3.2e-43 147.9 0.0 3.8e-43 147.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Trp_DMAT PF11991.3 CCF36178.1 - 6.3e-64 216.4 0.0 1.1e-63 215.6 0.0 1.4 1 1 0 1 1 1 1 Tryptophan dimethylallyltransferase p450 PF00067.17 CCF36180.1 - 1.1e-49 169.2 0.0 1.4e-49 168.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 CCF36181.1 - 6.2e-19 67.8 0.0 9.7e-19 67.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 TRAP_alpha PF03896.11 CCF36182.1 - 1 8.3 2.8 2.6 6.9 2.0 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit TroA PF01297.12 CCF36183.1 - 0.02 14.1 0.2 0.032 13.4 0.1 1.3 1 0 0 1 1 1 0 Periplasmic solute binding protein family Pardaxin PF07425.6 CCF36183.1 - 6.5 6.2 5.9 35 3.8 0.0 2.4 1 1 1 2 2 2 0 Pardaxin RRM_1 PF00076.17 CCF36184.1 - 4.9e-19 67.7 0.1 1.2e-11 44.0 0.0 4.0 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF36184.1 - 1e-17 63.8 0.0 1.6e-08 34.4 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF36184.1 - 0.014 15.2 0.0 0.81 9.5 0.0 2.9 4 0 0 4 4 4 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HTH_32 PF13565.1 CCF36184.1 - 0.38 11.5 6.5 8 7.3 0.1 3.6 3 0 0 3 3 3 0 Homeodomain-like domain Phostensin PF13914.1 CCF36184.1 - 7.4 6.6 9.3 40 4.3 0.5 3.5 4 0 0 4 4 4 0 Phostensin PP1-binding and SH3-binding region Peptidase_S28 PF05577.7 CCF36185.1 - 4.4e-49 167.2 0.0 5.3e-48 163.6 0.0 2.0 1 1 0 1 1 1 1 Serine carboxypeptidase S28 GMC_oxred_N PF00732.14 CCF36186.1 - 3.4e-49 167.5 0.0 4.4e-49 167.2 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF36186.1 - 1.2e-39 135.8 0.0 2e-39 135.1 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.7 CCF36186.1 - 0.00035 19.6 0.4 0.00063 18.7 0.2 1.5 2 0 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.19 CCF36186.1 - 0.001 18.0 0.1 0.0027 16.6 0.1 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF36186.1 - 0.0044 17.0 0.1 0.01 15.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HHH PF00633.18 CCF36186.1 - 0.054 13.2 0.0 0.15 11.8 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif FAD_binding_2 PF00890.19 CCF36186.1 - 0.068 12.0 1.1 0.11 11.3 0.7 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.9 CCF36186.1 - 0.1 12.4 0.2 0.21 11.4 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.13 CCF36186.1 - 0.13 12.2 0.1 5.7 6.9 0.0 2.4 2 0 0 2 2 2 0 TrkA-N domain Acyl_transf_1 PF00698.16 CCF36189.1 - 2.5e-51 174.9 0.0 7.8e-51 173.2 0.0 1.9 1 1 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.1 CCF36189.1 - 5.6e-42 143.9 0.2 1.2e-41 142.8 0.1 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.17 CCF36189.1 - 6e-39 132.5 0.1 2.4e-38 130.6 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N PF00107.21 CCF36189.1 - 1.3e-16 60.3 0.0 1.1e-15 57.3 0.0 2.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ketoacyl-synt PF00109.21 CCF36189.1 - 2.5e-13 50.0 0.1 5.1e-13 49.0 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.5 CCF36189.1 - 4.8e-09 36.1 0.9 1.9e-08 34.2 0.3 2.4 2 0 0 2 2 2 1 KR domain ADH_zinc_N_2 PF13602.1 CCF36189.1 - 1.1e-07 32.7 0.0 8.6e-07 29.9 0.0 2.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.20 CCF36189.1 - 2.2e-07 30.9 0.6 2.2e-07 30.9 0.4 2.9 2 0 0 2 2 2 1 short chain dehydrogenase ADH_N PF08240.7 CCF36189.1 - 5.7e-07 29.2 0.1 1.5e-06 27.9 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Yippee-Mis18 PF03226.9 CCF36190.1 - 5.8e-12 45.4 0.0 8e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF2457 PF10446.4 CCF36190.1 - 0.021 13.5 5.8 0.021 13.5 4.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Peptidase_M20 PF01546.23 CCF36191.1 - 5.1e-33 114.1 0.0 7.6e-33 113.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 CCF36191.1 - 2.5e-14 52.9 0.0 3.9e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain DWNN PF08783.6 CCF36192.1 - 1e-29 102.2 0.0 2e-29 101.3 0.0 1.5 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.1 CCF36192.1 - 0.00042 19.7 3.6 0.0014 18.0 2.5 1.9 1 0 0 1 1 1 1 Zinc knuckle zf-RING_6 PF14835.1 CCF36192.1 - 0.0082 15.9 1.6 0.014 15.1 1.1 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-CCHC PF00098.18 CCF36192.1 - 0.009 15.9 1.5 0.009 15.9 1.0 2.1 2 0 0 2 2 2 1 Zinc knuckle DUF966 PF06136.8 CCF36192.1 - 0.0098 15.3 6.1 0.019 14.3 0.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF966) zf-Nse PF11789.3 CCF36192.1 - 0.044 13.3 6.7 0.19 11.2 4.9 1.7 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.1 CCF36192.1 - 2.3 8.2 16.2 0.23 11.4 6.9 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CCF36192.1 - 3 7.8 11.5 7 6.6 8.0 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.20 CCF36192.1 - 3.2 7.4 11.6 6.2 6.5 8.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C2H2 PF00096.21 CCF36193.1 - 0.27 11.6 3.2 0.46 10.9 2.2 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type CDC27 PF09507.5 CCF36193.1 - 0.35 10.0 14.6 0.38 9.9 10.1 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Gag_spuma PF03276.9 CCF36193.1 - 1.6 6.9 8.6 1.9 6.7 5.9 1.2 1 0 0 1 1 1 0 Spumavirus gag protein p450 PF00067.17 CCF36194.1 - 3.6e-53 180.7 0.0 4.1e-53 180.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Antimicrobial20 PF08256.6 CCF36194.1 - 0.17 12.2 2.2 0.76 10.2 1.5 2.2 1 0 0 1 1 1 0 Aurein-like antibiotic peptide CBM_21 PF03370.8 CCF36195.1 - 2.4e-33 114.5 0.0 4.2e-33 113.7 0.0 1.4 1 0 0 1 1 1 1 Putative phosphatase regulatory subunit Nramp PF01566.13 CCF36196.1 - 2.2e-82 276.7 25.5 2.2e-82 276.7 17.6 1.7 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein BRAP2 PF07576.7 CCF36197.1 - 1.1e-20 73.2 0.0 2e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.14 CCF36197.1 - 1.1e-19 70.2 6.3 5.7e-19 68.0 3.5 2.4 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.1 CCF36197.1 - 4.2e-10 39.2 10.1 4.2e-10 39.2 7.0 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.20 CCF36197.1 - 2.5e-06 27.0 8.1 6.9e-06 25.6 5.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF36197.1 - 1.1e-05 25.0 8.6 1.1e-05 25.0 6.0 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 CCF36197.1 - 0.0001 21.9 7.3 0.0001 21.9 5.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CCF36197.1 - 0.00014 21.7 9.5 0.00014 21.7 6.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 CCF36197.1 - 0.0018 17.9 2.0 0.0018 17.9 1.4 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.2 CCF36197.1 - 0.004 17.2 5.6 0.004 17.2 3.9 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger zf-RING_6 PF14835.1 CCF36197.1 - 0.0064 16.2 3.5 0.017 14.8 2.4 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-Apc11 PF12861.2 CCF36197.1 - 0.09 12.6 7.3 0.23 11.3 5.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 CCF36197.1 - 0.25 10.9 7.1 0.55 9.8 4.9 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 CCF36197.1 - 0.39 10.6 5.8 2.4 8.1 4.1 2.4 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.1 CCF36197.1 - 1.9 8.0 11.5 25 4.5 0.1 2.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 DUF4200 PF13863.1 CCF36197.1 - 4.6 7.1 13.6 0.76 9.7 1.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) ubiquitin PF00240.18 CCF36198.1 - 6.6e-42 140.7 3.2 8.7e-35 117.9 0.6 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.3 CCF36198.1 - 2.4e-23 81.5 0.7 3.2e-20 71.5 0.5 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 CCF36198.1 - 1.1e-07 31.9 0.7 1.3e-05 25.3 0.1 2.7 2 1 0 2 2 2 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 CCF36198.1 - 6.5e-06 25.9 0.1 5e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Telomere stability and silencing Rad60-SLD_2 PF13881.1 CCF36198.1 - 0.0042 16.9 0.1 0.012 15.4 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 CCF36198.1 - 0.012 15.7 0.0 0.017 15.3 0.0 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Plexin_cytopl PF08337.7 CCF36198.1 - 0.021 13.1 1.2 0.37 9.0 0.3 2.5 1 1 1 2 2 2 0 Plexin cytoplasmic RasGAP domain DUF2870 PF11069.3 CCF36198.1 - 0.085 12.9 0.0 0.29 11.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) Methyltrans_RNA PF04452.9 CCF36198.1 - 0.11 11.5 0.1 0.18 10.9 0.0 1.4 2 0 0 2 2 2 0 RNA methyltransferase Nfu_N PF08712.6 CCF36199.1 - 3.6e-29 100.2 0.0 1.3e-28 98.3 0.0 2.0 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.12 CCF36199.1 - 2.4e-20 72.0 0.1 4.2e-20 71.2 0.1 1.4 1 0 0 1 1 1 1 NifU-like domain PSP1 PF04468.7 CCF36202.1 - 2.7e-30 104.1 0.5 2.7e-30 104.1 0.4 2.2 3 0 0 3 3 3 1 PSP1 C-terminal conserved region RAB3GAP2_N PF14655.1 CCF36202.1 - 0.22 10.4 9.6 0.83 8.5 1.1 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Rotavirus_VP3 PF06929.6 CCF36202.1 - 0.35 8.7 0.4 0.5 8.1 0.3 1.1 1 0 0 1 1 1 0 Rotavirus VP3 protein Spt20 PF12090.3 CCF36202.1 - 1.7 7.9 13.3 0.29 10.4 0.2 2.8 3 0 0 3 3 3 0 Spt20 family DUF4078 PF13300.1 CCF36205.1 - 8.8e-28 96.2 18.2 8.8e-28 96.2 12.6 2.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4078) Ydc2-catalyt PF09159.5 CCF36205.1 - 0.37 10.2 6.3 0.058 12.8 1.3 1.8 1 1 0 2 2 2 0 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 DUF2407_C PF13373.1 CCF36205.1 - 2.5 8.0 5.4 2.5 8.0 0.3 2.3 2 0 0 2 2 2 0 DUF2407 C-terminal domain Amidohydro_2 PF04909.9 CCF36206.1 - 6.1e-26 91.5 0.5 7.1e-26 91.3 0.3 1.0 1 0 0 1 1 1 1 Amidohydrolase Cutinase PF01083.17 CCF36207.1 - 3e-29 102.0 0.0 4.5e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 Cutinase Abhydrolase_5 PF12695.2 CCF36207.1 - 0.0074 16.0 0.0 0.0095 15.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 CCF36207.1 - 0.026 13.9 0.0 0.039 13.3 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase PE-PPE PF08237.6 CCF36207.1 - 0.049 13.0 0.0 0.077 12.3 0.0 1.2 1 0 0 1 1 1 0 PE-PPE domain Topo_Zn_Ribbon PF08272.6 CCF36208.1 - 0.08 12.3 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Topoisomerase I zinc-ribbon-like TFIIF_alpha PF05793.7 CCF36209.1 - 4.9e-06 25.1 63.7 4.9e-06 25.1 44.2 1.9 1 1 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Bud13 PF09736.4 CCF36210.1 - 8e-45 152.6 6.3 8e-45 152.6 4.3 1.7 2 0 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex Utp14 PF04615.8 CCF36210.1 - 1.8 6.6 19.7 0.027 12.6 8.2 1.7 2 0 0 2 2 2 0 Utp14 protein Cation_efflux PF01545.16 CCF36212.1 - 1.9e-30 105.8 7.1 2.4e-30 105.5 4.9 1.0 1 0 0 1 1 1 1 Cation efflux family DUF1645 PF07816.6 CCF36213.1 - 0.0018 18.7 3.9 0.0018 18.7 2.7 2.0 3 0 0 3 3 3 1 Protein of unknown function (DUF1645) Tetraspannin PF00335.15 CCF36213.1 - 1.4 8.1 3.9 2.2 7.4 2.7 1.3 1 0 0 1 1 1 0 Tetraspanin family p450 PF00067.17 CCF36215.1 - 2.8e-13 49.2 0.0 8e-07 27.9 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 DUF4231 PF14015.1 CCF36218.1 - 0.094 12.7 0.1 0.098 12.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) Aldo_ket_red PF00248.16 CCF36219.1 - 1.2e-52 178.4 0.0 1.4e-52 178.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Ribonuclease PF00545.15 CCF36220.1 - 8e-20 70.7 2.0 3.3e-19 68.7 0.1 1.9 1 1 1 2 2 2 1 ribonuclease Flavi_NS1 PF00948.16 CCF36220.1 - 0.00065 18.2 0.3 0.0007 18.1 0.2 1.2 1 0 0 1 1 1 1 Flavivirus non-structural Protein NS1 DUF3602 PF12223.3 CCF36221.1 - 1.9e-15 56.9 7.0 1.8e-13 50.6 0.6 2.8 2 2 1 3 3 3 2 Protein of unknown function (DUF3602) URO-D PF01208.12 CCF36222.1 - 1.2e-105 353.2 0.0 1.4e-105 352.9 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) DNAPolymera_Pol PF11590.3 CCF36223.1 - 0.094 12.4 0.8 0.3 10.7 0.0 2.2 2 0 0 2 2 2 0 DNA polymerase catalytic subunit Pol NAD_binding_10 PF13460.1 CCF36227.1 - 1.2e-05 25.4 0.0 1.5e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 CCF36227.1 - 0.05 12.5 0.0 0.096 11.5 0.0 1.5 1 1 1 2 2 2 0 Male sterility protein Adaptin_binding PF10199.4 CCF36228.1 - 0.69 10.1 11.1 1.2 9.3 7.5 1.4 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 HET PF06985.6 CCF36230.1 - 1.4e-25 90.0 0.0 4e-25 88.5 0.0 1.8 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) adh_short PF00106.20 CCF36232.1 - 2.5e-20 73.0 5.4 5.7e-19 68.6 3.8 2.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF36232.1 - 1.1e-10 41.7 0.0 2.3e-10 40.6 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF36232.1 - 3.2e-10 39.9 0.5 9.7e-10 38.3 0.3 1.8 1 1 1 2 2 2 1 KR domain Epimerase PF01370.16 CCF36232.1 - 0.00088 18.7 0.2 0.019 14.4 0.0 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.15 CCF36232.1 - 0.0049 16.9 0.0 0.0072 16.4 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 3Beta_HSD PF01073.14 CCF36232.1 - 0.016 13.9 0.1 0.027 13.1 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 CCF36232.1 - 0.028 14.4 0.1 0.057 13.4 0.1 1.4 1 0 0 1 1 1 0 NADH(P)-binding Saccharop_dh PF03435.13 CCF36232.1 - 0.064 12.2 0.1 0.09 11.7 0.1 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase Polysacc_synt_2 PF02719.10 CCF36232.1 - 0.1 11.5 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein KH_1 PF00013.24 CCF36233.1 - 4.3e-42 141.5 12.1 3e-14 52.3 1.0 3.4 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 CCF36233.1 - 3.8e-31 106.1 17.0 2.2e-11 43.1 0.1 3.9 4 0 0 4 4 4 3 KH domain KH_2 PF07650.12 CCF36233.1 - 1.8e-13 49.8 1.4 0.0016 17.9 0.0 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.1 CCF36233.1 - 5.2e-08 32.4 4.3 0.2 11.3 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.1 CCF36233.1 - 0.00038 20.1 5.1 2.1 8.2 0.6 3.9 3 1 0 3 3 3 2 NusA-like KH domain SLS PF14611.1 CCF36233.1 - 0.11 11.9 0.0 19 4.5 0.0 2.9 3 0 0 3 3 3 0 Mitochondrial inner-membrane-bound regulator HMGL-like PF00682.14 CCF36234.1 - 1.8e-36 126.0 0.0 6.3e-36 124.2 0.0 1.7 1 1 0 1 1 1 1 HMGL-like ATP-synt_ab PF00006.20 CCF36235.1 - 1.8e-59 200.8 0.0 2.8e-59 200.2 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 CCF36235.1 - 1.3e-17 64.2 0.6 2.4e-17 63.4 0.4 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 CCF36235.1 - 1.2e-13 51.0 1.1 2.9e-13 49.8 0.7 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 CCF36235.1 - 3.8e-05 23.4 0.4 7.8e-05 22.5 0.3 1.5 1 0 0 1 1 1 1 HAS barrel domain DUF561 PF04481.7 CCF36235.1 - 0.14 11.0 0.0 0.23 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF561) ADH_N PF08240.7 CCF36236.1 - 9e-30 102.6 1.6 1.5e-29 101.9 1.1 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF36236.1 - 1e-18 67.1 0.0 1.5e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.1 CCF36236.1 - 3.2e-05 23.4 0.0 6.8e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated ADH_zinc_N_2 PF13602.1 CCF36236.1 - 0.0021 18.9 0.0 0.0035 18.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Sen15 PF09631.5 CCF36237.1 - 3.8e-27 94.4 0.0 6.4e-27 93.7 0.0 1.4 1 0 0 1 1 1 1 Sen15 protein Fungal_trans PF04082.13 CCF36239.1 - 6.4e-13 48.1 0.0 1e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain HLH PF00010.21 CCF36242.1 - 4.7e-16 58.2 0.0 8.6e-16 57.3 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain bZIP_1 PF00170.16 CCF36242.1 - 0.04 13.8 1.1 0.087 12.8 0.8 1.5 1 0 0 1 1 1 0 bZIP transcription factor DUF904 PF06005.7 CCF36242.1 - 0.068 13.4 1.3 0.16 12.2 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF904) DUF3186 PF11382.3 CCF36242.1 - 0.092 11.8 0.5 0.15 11.1 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3186) DivIC PF04977.10 CCF36242.1 - 0.1 12.0 2.1 0.25 10.8 1.4 1.6 1 0 0 1 1 1 0 Septum formation initiator DUF972 PF06156.8 CCF36242.1 - 0.18 12.1 2.5 0.33 11.2 1.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Ndc1_Nup PF09531.5 CCF36242.1 - 1.1 7.6 9.0 1.3 7.4 6.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FNIP_N PF14636.1 CCF36242.1 - 1.3 9.5 11.8 0.48 10.8 5.3 2.3 3 0 0 3 3 3 0 Folliculin-interacting protein N-terminus NUDIX PF00293.23 CCF36246.1 - 3e-10 39.8 0.0 4.6e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain SnoaL_2 PF12680.2 CCF36248.1 - 3.5e-12 46.6 0.1 4.3e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.7 CCF36248.1 - 1.9e-08 33.9 0.5 8e-07 28.6 0.3 2.0 1 1 0 1 1 1 1 SnoaL-like polyketide cyclase DUF1411 PF07199.6 CCF36249.1 - 8.7 5.7 7.9 10 5.4 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) BRCT PF00533.21 CCF36252.1 - 0.0018 18.3 0.0 0.0042 17.2 0.0 1.7 1 1 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain tRNA-synt_2b PF00587.20 CCF36255.1 - 2.8e-36 124.6 0.0 5.7e-36 123.7 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 CCF36255.1 - 4.2e-14 52.4 6.6 9.5e-14 51.3 4.6 1.6 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Vfa1 PF08432.5 CCF36255.1 - 0.41 10.6 8.1 0.79 9.7 5.6 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 TPR_11 PF13414.1 CCF36256.1 - 3.3e-07 29.8 3.4 6.4e-06 25.7 0.1 2.9 2 1 0 2 2 2 1 TPR repeat TPR_12 PF13424.1 CCF36256.1 - 1.2e-06 28.3 1.0 0.00057 19.7 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat SHNi-TPR PF10516.4 CCF36256.1 - 4.6e-06 25.7 5.2 9.8e-06 24.7 0.1 3.1 3 1 0 3 3 3 1 SHNi-TPR TPR_16 PF13432.1 CCF36256.1 - 0.00023 21.7 0.0 0.00023 21.7 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 CCF36256.1 - 0.00032 20.3 1.3 0.00032 20.3 0.9 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 CCF36256.1 - 0.00043 19.7 2.4 0.00054 19.4 0.7 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 CCF36256.1 - 0.096 13.3 1.1 0.48 11.1 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.7 CCF36256.1 - 0.17 11.6 2.0 0.48 10.2 0.9 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat p450 PF00067.17 CCF36258.1 - 1.9e-57 194.8 0.2 1.7e-56 191.7 0.1 1.9 1 1 0 1 1 1 1 Cytochrome P450 PsbL PF02419.12 CCF36258.1 - 0.64 9.4 2.3 1.2 8.6 1.6 1.3 1 0 0 1 1 1 0 PsbL protein Amidohydro_1 PF01979.15 CCF36259.1 - 2e-13 50.7 0.0 1.8e-12 47.6 0.0 2.0 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 CCF36259.1 - 3.6e-13 49.1 1.5 3.1e-12 46.1 0.1 3.2 3 1 0 3 3 3 1 Amidohydrolase Amidohydro_4 PF13147.1 CCF36259.1 - 2.8e-06 27.5 0.9 0.041 13.9 0.1 3.1 2 1 0 2 2 2 2 Amidohydrolase Amidohydro_3 PF07969.6 CCF36259.1 - 0.00014 21.2 1.4 0.017 14.3 0.0 2.4 2 1 0 2 2 2 2 Amidohydrolase family TPP_enzyme_M PF00205.17 CCF36259.1 - 0.00095 18.9 0.0 0.5 10.1 0.0 2.5 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Caps_synth PF05704.7 CCF36262.1 - 2.4e-11 43.3 0.0 3.8e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.10 CCF36262.1 - 6.2e-05 23.3 0.0 0.00016 21.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Docking PF08990.6 CCF36262.1 - 0.026 13.7 0.0 0.056 12.6 0.0 1.5 1 0 0 1 1 1 0 Erythronolide synthase docking PqqD PF05402.7 CCF36262.1 - 0.085 12.8 0.8 0.27 11.2 0.0 2.2 3 0 0 3 3 3 0 Coenzyme PQQ synthesis protein D (PqqD) p450 PF00067.17 CCF36263.1 - 8.5e-38 130.0 0.0 1.1e-37 129.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_2 PF00891.13 CCF36264.1 - 6.5e-31 107.3 0.0 9.1e-31 106.8 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase CheR PF01739.13 CCF36264.1 - 0.0051 16.1 0.0 0.0091 15.2 0.0 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_18 PF12847.2 CCF36264.1 - 0.03 14.8 0.0 0.12 12.9 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain DUF3720 PF12517.3 CCF36267.1 - 1.7 9.4 4.9 6 7.6 3.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3720) Tropomyosin_1 PF12718.2 CCF36268.1 - 1.8e-49 167.2 32.2 2.1e-49 167.0 22.3 1.0 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.15 CCF36268.1 - 4.7e-09 35.6 31.2 1.3e-05 24.3 9.0 2.9 1 1 2 3 3 3 3 Tropomyosin ATG16 PF08614.6 CCF36268.1 - 0.00011 22.0 27.1 0.0017 18.1 11.0 2.1 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) Mod_r PF07200.8 CCF36268.1 - 0.00012 22.0 24.0 0.002 18.0 11.1 2.1 1 1 1 2 2 2 2 Modifier of rudimentary (Mod(r)) protein Cast PF10174.4 CCF36268.1 - 0.00021 19.4 25.0 0.00024 19.3 17.4 1.1 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone CENP-F_leu_zip PF10473.4 CCF36268.1 - 0.00037 20.3 3.9 0.00037 20.3 2.7 3.0 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd PF12325.3 CCF36268.1 - 0.00059 19.5 24.7 0.0077 15.9 11.8 2.4 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding GAS PF13851.1 CCF36268.1 - 0.001 18.3 29.1 0.0018 17.4 20.1 1.5 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding Myosin_tail_1 PF01576.14 CCF36268.1 - 0.0012 16.6 30.2 0.0015 16.4 20.9 1.0 1 0 0 1 1 1 1 Myosin tail DUF4200 PF13863.1 CCF36268.1 - 0.0016 18.3 30.6 0.082 12.8 6.1 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4200) ERM PF00769.14 CCF36268.1 - 0.0021 17.6 33.7 0.027 14.0 10.2 2.2 1 1 1 2 2 2 2 Ezrin/radixin/moesin family ADIP PF11559.3 CCF36268.1 - 0.0028 17.5 28.3 0.0095 15.8 5.2 3.1 1 1 2 3 3 3 1 Afadin- and alpha -actinin-Binding APG6 PF04111.7 CCF36268.1 - 0.0042 16.1 31.8 0.064 12.2 10.9 2.0 1 1 1 2 2 2 2 Autophagy protein Apg6 Spc7 PF08317.6 CCF36268.1 - 0.0056 15.3 24.7 0.0093 14.6 7.7 2.0 1 1 1 2 2 2 2 Spc7 kinetochore protein CCDC155 PF14662.1 CCF36268.1 - 0.015 14.8 31.4 0.12 11.9 7.6 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 IncA PF04156.9 CCF36268.1 - 0.023 14.2 28.3 0.9 9.0 19.6 2.1 1 1 0 1 1 1 0 IncA protein V_ATPase_I PF01496.14 CCF36268.1 - 0.023 12.5 15.1 0.03 12.1 10.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family bZIP_1 PF00170.16 CCF36268.1 - 0.025 14.5 29.5 0.71 9.8 1.7 4.9 2 1 4 6 6 5 0 bZIP transcription factor Surfac_D-trimer PF09006.6 CCF36268.1 - 0.026 14.2 5.3 0.068 12.9 0.0 3.5 4 0 0 4 4 3 0 Lung surfactant protein D coiled-coil trimerisation FlaC_arch PF05377.6 CCF36268.1 - 0.026 14.3 17.7 0.99 9.3 1.9 4.3 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Lebercilin PF15619.1 CCF36268.1 - 0.033 13.5 29.7 1.2 8.5 10.6 2.1 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease TPR_MLP1_2 PF07926.7 CCF36268.1 - 0.036 13.8 29.4 0.26 11.0 8.3 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein EzrA PF06160.7 CCF36268.1 - 0.045 11.9 22.5 0.032 12.4 3.3 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Syntaxin-6_N PF09177.6 CCF36268.1 - 0.052 13.9 16.5 0.83 10.0 2.2 2.7 1 1 2 3 3 3 0 Syntaxin 6, N-terminal TMF_DNA_bd PF12329.3 CCF36268.1 - 0.058 13.1 30.5 0.24 11.2 8.9 3.0 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding KLRAQ PF10205.4 CCF36268.1 - 0.076 13.0 18.3 0.068 13.2 4.7 2.9 1 1 2 3 3 3 0 Predicted coiled-coil domain-containing protein NPV_P10 PF05531.7 CCF36268.1 - 0.078 13.2 9.0 11 6.3 0.0 3.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF3287 PF11690.3 CCF36268.1 - 0.081 13.0 7.4 0.084 12.9 1.7 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF3287) Seryl_tRNA_N PF02403.17 CCF36268.1 - 0.084 12.8 25.7 0.16 12.0 0.3 3.1 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain HAP1_N PF04849.8 CCF36268.1 - 0.085 11.7 26.2 0.17 10.7 18.2 1.9 1 1 0 1 1 1 0 HAP1 N-terminal conserved region Filament PF00038.16 CCF36268.1 - 0.091 12.2 25.2 0.27 10.6 17.5 1.7 1 1 0 1 1 1 0 Intermediate filament protein Cortex-I_coil PF09304.5 CCF36268.1 - 0.1 12.6 25.7 2.1 8.4 0.1 3.2 1 1 2 3 3 3 0 Cortexillin I, coiled coil Fib_alpha PF08702.5 CCF36268.1 - 0.11 12.5 16.3 0.9 9.6 3.1 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family TBPIP PF07106.8 CCF36268.1 - 0.12 11.9 24.8 1.2 8.7 6.8 3.0 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Jnk-SapK_ap_N PF09744.4 CCF36268.1 - 0.13 12.2 23.8 0.18 11.7 8.7 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Serine_rich PF08824.5 CCF36268.1 - 0.14 11.8 5.8 0.27 10.9 3.5 1.9 1 1 0 1 1 1 0 Serine rich protein interaction domain AAA_13 PF13166.1 CCF36268.1 - 0.15 10.4 21.7 0.41 9.0 15.1 1.6 1 1 0 1 1 1 0 AAA domain Laminin_II PF06009.7 CCF36268.1 - 0.16 11.7 16.7 0.026 14.2 3.7 2.5 1 1 1 2 2 2 0 Laminin Domain II BLOC1_2 PF10046.4 CCF36268.1 - 0.16 12.1 18.5 0.63 10.2 3.5 3.2 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Striatin PF08232.7 CCF36268.1 - 0.19 12.0 23.0 0.097 12.9 9.7 2.1 1 1 0 2 2 2 0 Striatin family Fmp27_WPPW PF10359.4 CCF36268.1 - 0.2 10.0 21.2 0.064 11.6 5.5 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain Atg14 PF10186.4 CCF36268.1 - 0.21 10.5 22.4 0.061 12.2 9.2 2.0 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Reo_sigmaC PF04582.7 CCF36268.1 - 0.25 10.4 3.1 3.3 6.8 0.1 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Herpes_pp85 PF04637.7 CCF36268.1 - 0.25 9.5 4.7 0.051 11.8 0.8 1.6 2 0 0 2 2 2 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) HOOK PF05622.7 CCF36268.1 - 0.35 8.6 24.1 0.47 8.2 16.7 1.1 1 0 0 1 1 1 0 HOOK protein PilJ PF13675.1 CCF36268.1 - 0.38 11.0 11.6 1.9 8.8 3.2 2.8 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Nup54 PF13874.1 CCF36268.1 - 0.46 10.1 20.7 0.32 10.6 3.7 2.7 1 1 2 3 3 3 0 Nucleoporin complex subunit 54 DUF3450 PF11932.3 CCF36268.1 - 0.65 9.2 23.2 0.53 9.4 7.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) WXG100 PF06013.7 CCF36268.1 - 0.7 9.9 15.8 3 7.9 0.2 4.1 3 1 1 4 4 4 0 Proteins of 100 residues with WXG Herpes_capsid PF06112.6 CCF36268.1 - 0.71 9.9 3.3 0.37 10.8 0.5 1.8 2 0 0 2 2 1 0 Gammaherpesvirus capsid protein DUF1664 PF07889.7 CCF36268.1 - 0.76 9.5 13.0 2.4 7.9 1.9 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) rRNA_proc-arch PF13234.1 CCF36268.1 - 0.87 8.6 13.5 0.11 11.6 2.2 2.4 1 1 0 2 2 2 0 rRNA-processing arch domain FliD_N PF02465.13 CCF36268.1 - 0.91 9.9 12.2 1.9 8.9 0.3 3.0 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 N-terminus CDC37_N PF03234.9 CCF36268.1 - 1.1 9.5 22.3 7.1 6.9 15.4 2.3 1 1 0 1 1 1 0 Cdc37 N terminal kinase binding DUF869 PF05911.6 CCF36268.1 - 1.2 7.3 24.3 5.2 5.1 16.9 1.8 1 1 0 1 1 1 0 Plant protein of unknown function (DUF869) Lge1 PF11488.3 CCF36268.1 - 1.2 9.4 19.9 0.33 11.1 2.4 2.9 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 DUF3584 PF12128.3 CCF36268.1 - 1.2 6.3 26.8 2.3 5.4 18.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) DUF904 PF06005.7 CCF36268.1 - 1.3 9.4 35.4 4.2 7.7 1.6 3.7 1 1 2 3 3 2 0 Protein of unknown function (DUF904) Mnd1 PF03962.10 CCF36268.1 - 1.3 8.6 28.4 3.2 7.3 6.9 2.1 1 1 1 2 2 2 0 Mnd1 family IFT46_B_C PF12317.3 CCF36268.1 - 1.5 8.0 7.5 0.25 10.6 2.0 1.8 1 1 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal DUF972 PF06156.8 CCF36268.1 - 1.6 9.1 24.6 1.5e+04 -4.2 17.0 3.1 1 1 0 1 1 0 0 Protein of unknown function (DUF972) MAD PF05557.8 CCF36268.1 - 2.2 6.2 26.1 30 2.5 18.1 2.0 1 1 0 1 1 1 0 Mitotic checkpoint protein Shugoshin_N PF07558.6 CCF36268.1 - 2.3 7.9 8.6 0.88 9.3 1.2 3.4 2 1 0 3 3 2 0 Shugoshin N-terminal coiled-coil region CENP-K PF11802.3 CCF36268.1 - 2.8 7.1 13.6 0.017 14.3 2.0 2.0 1 1 1 2 2 2 0 Centromere-associated protein K FUSC PF04632.7 CCF36268.1 - 2.9 6.2 4.0 3.3 6.0 2.8 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4201 PF13870.1 CCF36268.1 - 3 7.2 23.4 25 4.2 16.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) Sec5 PF15469.1 CCF36268.1 - 4.1 7.0 13.0 0.58 9.8 0.7 2.5 1 1 1 2 2 2 0 Exocyst complex component Sec5 DUF4140 PF13600.1 CCF36268.1 - 4.1 7.8 21.0 7.7 7.0 1.7 3.2 1 1 1 2 2 1 0 N-terminal domain of unknown function (DUF4140) OmpH PF03938.9 CCF36268.1 - 5.2 6.9 30.8 1 9.2 11.4 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) EHN PF06441.7 CCF36268.1 - 6 6.8 10.3 9 6.2 2.8 2.3 1 1 1 2 2 2 0 Epoxide hydrolase N terminus HSP70 PF00012.15 CCF36268.1 - 6.2 4.5 17.4 8.3 4.1 12.0 1.3 1 0 0 1 1 1 0 Hsp70 protein DUF745 PF05335.8 CCF36268.1 - 6.3 6.2 18.7 0.25 10.8 3.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF724 PF05266.9 CCF36268.1 - 7.7 6.0 25.7 4 7.0 6.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) FliJ PF02050.11 CCF36268.1 - 7.9 6.5 27.1 15 5.6 12.0 2.6 1 1 1 2 2 2 0 Flagellar FliJ protein Cep57_MT_bd PF06657.8 CCF36268.1 - 8.1 6.4 16.9 0.63 10.0 1.7 3.4 1 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 SlyX PF04102.7 CCF36268.1 - 8.6 6.8 19.4 13 6.2 3.8 3.6 1 1 2 4 4 4 0 SlyX Uso1_p115_C PF04871.8 CCF36268.1 - 9.2 6.1 25.7 4.4 7.2 9.6 2.4 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Nop25 PF09805.4 CCF36269.1 - 5.6e-34 117.1 15.9 5.6e-34 117.1 11.0 2.3 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) ATP-synt_S1 PF05827.7 CCF36270.1 - 1.5e-31 109.7 0.0 2.3e-30 105.8 0.0 2.2 1 1 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Trm112p PF03966.11 CCF36271.1 - 2.1e-18 66.4 0.1 2.7e-18 66.1 0.1 1.1 1 0 0 1 1 1 1 Trm112p-like protein Zn_ribbon_recom PF13408.1 CCF36271.1 - 0.051 13.8 0.2 0.087 13.1 0.2 1.3 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain Glyco_hydro_3 PF00933.16 CCF36272.1 - 7.2e-92 307.5 0.0 1.1e-91 307.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 CCF36272.1 - 1.8e-57 194.5 0.7 5.4e-56 189.6 0.1 2.3 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 CCF36272.1 - 5.2e-18 64.7 0.0 1.1e-17 63.6 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain Homeobox_KN PF05920.6 CCF36273.1 - 2.3e-21 75.1 0.4 6e-21 73.8 0.3 1.8 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.24 CCF36273.1 - 4e-08 32.7 1.3 4e-08 32.7 0.9 1.7 2 0 0 2 2 2 1 Homeobox domain Ufd2P_core PF10408.4 CCF36274.1 - 5.1e-121 404.9 0.6 6.1e-121 404.6 0.4 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core zf-TRAF PF02176.13 CCF36275.1 - 7.8e-09 35.7 21.9 5e-07 29.9 4.1 3.2 1 1 3 4 4 4 3 TRAF-type zinc finger Mnd1 PF03962.10 CCF36275.1 - 0.0047 16.6 5.2 0.0047 16.6 3.6 1.5 2 0 0 2 2 2 1 Mnd1 family Laminin_II PF06009.7 CCF36275.1 - 0.015 15.0 4.0 0.34 10.6 0.2 3.2 3 1 1 4 4 4 0 Laminin Domain II DivIC PF04977.10 CCF36275.1 - 0.021 14.3 5.3 0.079 12.4 2.0 2.4 2 0 0 2 2 2 0 Septum formation initiator TMF_DNA_bd PF12329.3 CCF36275.1 - 0.061 13.1 8.8 0.18 11.6 3.3 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF342 PF03961.8 CCF36275.1 - 0.079 11.3 1.6 0.11 10.9 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) IncA PF04156.9 CCF36275.1 - 0.12 11.9 6.5 0.25 10.9 4.5 1.6 1 1 0 1 1 1 0 IncA protein DUF16 PF01519.11 CCF36275.1 - 0.17 12.1 7.7 0.37 11.0 5.4 1.7 1 1 0 1 1 1 0 Protein of unknown function DUF16 Phage_GP20 PF06810.6 CCF36275.1 - 0.19 11.1 6.3 0.052 12.9 1.0 2.2 2 1 0 2 2 2 0 Phage minor structural protein GP20 Med9 PF07544.8 CCF36275.1 - 0.35 10.6 8.9 7.5 6.3 3.5 2.8 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 CENP-Q PF13094.1 CCF36275.1 - 0.36 10.8 5.4 0.94 9.4 3.7 1.7 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF848 PF05852.6 CCF36275.1 - 0.4 10.5 6.4 3 7.7 0.8 2.4 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) XhlA PF10779.4 CCF36275.1 - 0.42 10.5 7.4 7.6 6.5 1.6 2.4 2 0 0 2 2 2 0 Haemolysin XhlA Prefoldin_2 PF01920.15 CCF36275.1 - 0.47 10.2 11.1 1.6 8.5 2.7 2.6 2 1 0 2 2 2 0 Prefoldin subunit DUF4446 PF14584.1 CCF36275.1 - 1.2 8.9 4.0 1.9 8.3 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) SlyX PF04102.7 CCF36275.1 - 1.4 9.3 7.9 0.86 10.0 0.5 3.0 2 1 0 2 2 2 0 SlyX DUF2802 PF10975.3 CCF36275.1 - 2.5 7.9 7.1 17 5.2 0.9 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2802) Amidase PF01425.16 CCF36276.1 - 0.012 14.4 0.0 0.015 14.1 0.0 1.1 1 0 0 1 1 1 0 Amidase Acyltransferase PF01553.16 CCF36277.1 - 4.7e-10 39.0 0.0 0.00071 19.0 0.0 2.1 2 0 0 2 2 2 2 Acyltransferase MFS_1 PF07690.11 CCF36279.1 - 9.5e-10 37.7 8.9 1.2e-09 37.3 6.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF36279.1 - 2e-08 33.2 0.0 2.1e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 CCF36279.1 - 0.042 12.0 0.2 0.05 11.7 0.1 1.0 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) MMgT PF10270.4 CCF36280.1 - 3.7e-31 107.7 0.0 4.3e-31 107.4 0.0 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter HMG_box PF00505.14 CCF36281.1 - 2.9e-14 53.0 0.2 4.2e-13 49.3 0.1 2.3 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 CCF36281.1 - 0.00042 20.6 0.0 0.001 19.4 0.0 1.7 1 0 0 1 1 1 1 HMG-box domain MAT_Alpha1 PF04769.7 CCF36281.1 - 0.016 14.5 0.0 0.027 13.7 0.0 1.4 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 Hamartin PF04388.7 CCF36281.1 - 0.1 11.2 0.4 0.12 11.0 0.3 1.1 1 0 0 1 1 1 0 Hamartin protein Peptidase_M20 PF01546.23 CCF36282.1 - 6.8e-11 42.0 0.5 9.4e-11 41.5 0.4 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 CCF36282.1 - 1e-06 28.4 0.0 4.1e-06 26.5 0.0 2.1 1 1 0 1 1 1 1 Peptidase dimerisation domain DUF218 PF02698.12 CCF36283.1 - 7e-30 103.5 0.0 8.7e-30 103.2 0.0 1.1 1 0 0 1 1 1 1 DUF218 domain Glyco_hydro_3_C PF01915.17 CCF36284.1 - 9.7e-30 103.7 0.0 3.6e-21 75.7 0.3 3.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 CCF36284.1 - 3.4e-23 81.3 0.1 5.4e-23 80.7 0.1 1.3 1 0 0 1 1 1 1 Fibronectin type III-like domain Pectate_lyase PF03211.8 CCF36285.1 - 9.6e-39 133.0 0.5 1.1e-38 132.7 0.3 1.0 1 0 0 1 1 1 1 Pectate lyase IBR PF01485.16 CCF36286.1 - 7.6e-08 32.1 3.1 7.6e-08 32.1 2.2 3.4 3 1 0 3 3 3 2 IBR domain zf-AN1 PF01428.11 CCF36287.1 - 0.0012 18.6 4.6 0.0022 17.8 3.2 1.4 1 0 0 1 1 1 1 AN1-like Zinc finger FYVE PF01363.16 CCF36287.1 - 0.0019 18.0 1.2 0.0032 17.3 0.8 1.4 1 0 0 1 1 1 1 FYVE zinc finger zf-UBP PF02148.14 CCF36287.1 - 0.043 13.9 1.1 0.071 13.2 0.8 1.4 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein zf-HIT PF04438.11 CCF36287.1 - 0.05 13.2 4.7 0.092 12.4 3.3 1.4 1 0 0 1 1 1 0 HIT zinc finger DUF702 PF05142.7 CCF36287.1 - 0.064 13.4 3.7 0.061 13.4 1.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF702) zf-B_box PF00643.19 CCF36287.1 - 0.088 12.7 1.6 0.088 12.7 1.1 1.8 2 0 0 2 2 2 0 B-box zinc finger ACC_epsilon PF13822.1 CCF36287.1 - 1.5 9.2 7.6 3.1 8.2 5.3 1.5 1 0 0 1 1 1 0 Acyl-CoA carboxylase epsilon subunit PIG-P PF08510.7 CCF36288.1 - 3e-42 143.2 0.1 3.8e-42 142.8 0.1 1.1 1 0 0 1 1 1 1 PIG-P DUF4131 PF13567.1 CCF36288.1 - 0.044 13.1 0.1 0.073 12.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF485 PF04341.7 CCF36288.1 - 8.3 6.2 7.6 0.36 10.5 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF485 Actin PF00022.14 CCF36289.1 - 6.1e-143 475.9 0.0 6.9e-143 475.8 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 CCF36289.1 - 9.2e-07 27.7 0.0 0.002 16.7 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein DUF3591 PF12157.3 CCF36290.1 - 1.8e-179 596.9 2.4 2.6e-179 596.4 1.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) RGS PF00615.14 CCF36291.1 - 4.1e-38 130.1 0.4 2.9e-37 127.3 0.0 2.5 3 0 0 3 3 3 1 Regulator of G protein signaling domain DEP PF00610.16 CCF36291.1 - 6.1e-26 89.9 0.1 5.6e-21 74.0 0.0 3.4 2 1 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Replic_Relax PF13814.1 CCF36291.1 - 0.085 12.6 0.0 3.6 7.4 0.0 2.4 2 0 0 2 2 2 0 Replication-relaxation PG_binding_1 PF01471.13 CCF36293.1 - 0.0046 16.9 0.1 2.5 8.1 0.0 3.1 2 0 0 2 2 2 2 Putative peptidoglycan binding domain Myosin_tail_1 PF01576.14 CCF36293.1 - 0.025 12.3 6.0 0.037 11.7 4.1 1.1 1 0 0 1 1 1 0 Myosin tail AAA_13 PF13166.1 CCF36293.1 - 0.076 11.4 5.3 0.11 10.9 3.7 1.1 1 0 0 1 1 1 0 AAA domain Laminin_II PF06009.7 CCF36293.1 - 0.17 11.6 3.2 1.8 8.2 0.2 2.8 1 1 2 3 3 3 0 Laminin Domain II CENP-Q PF13094.1 CCF36293.1 - 0.38 10.7 5.3 6.2 6.8 3.2 2.4 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Peptidase_M35 PF02102.10 CCF36295.1 - 1.7e-07 30.2 0.1 1.9e-07 30.0 0.1 1.2 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family DUF2014 PF09427.5 CCF36296.1 - 7.6e-102 339.8 5.4 1.2e-101 339.2 3.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2014) HLH PF00010.21 CCF36296.1 - 9e-18 63.7 1.7 4.3e-17 61.5 0.5 2.3 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain CCDC155 PF14662.1 CCF36296.1 - 0.021 14.4 0.4 0.021 14.4 0.3 2.3 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 Sigma70_ner PF04546.8 CCF36296.1 - 0.077 12.5 4.1 0.19 11.3 2.8 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region PAT1 PF09770.4 CCF36296.1 - 0.97 7.5 13.3 1.5 6.9 9.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 A_deaminase PF00962.17 CCF36298.1 - 6.8e-20 71.2 0.0 1.2e-19 70.4 0.0 1.3 1 1 0 1 1 1 1 Adenosine/AMP deaminase MFS_1 PF07690.11 CCF36299.1 - 1.5e-31 109.4 12.9 1.5e-31 109.4 8.9 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily TauD PF02668.11 CCF36300.1 - 2e-50 171.8 0.2 2.5e-50 171.5 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Pkinase PF00069.20 CCF36301.1 - 4.7e-13 48.8 0.1 7e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF36301.1 - 2.5e-07 30.0 0.0 3.6e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CCF36301.1 - 7.6e-06 25.8 1.1 2.2e-05 24.2 0.4 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CCF36301.1 - 0.00029 20.4 0.1 0.0012 18.4 0.0 1.9 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kdo PF06293.9 CCF36301.1 - 0.00076 18.5 0.0 0.0012 17.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 CCF36301.1 - 0.0022 17.3 0.0 0.0043 16.4 0.0 1.4 1 0 0 1 1 1 1 RIO1 family SET PF00856.23 CCF36302.1 - 6.7e-22 78.5 0.0 1.2e-20 74.3 0.0 2.5 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.11 CCF36302.1 - 1.8e-19 69.8 8.0 4.8e-19 68.5 3.4 2.3 2 0 0 2 2 2 1 Pre-SET motif Fungal_trans PF04082.13 CCF36303.1 - 1.8e-17 63.0 1.0 4.9e-17 61.6 0.7 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF36303.1 - 2.7e-05 23.9 9.8 4.6e-05 23.2 6.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fcf1 PF04900.7 CCF36304.1 - 6.3e-36 122.5 0.6 2.1e-35 120.8 0.1 2.0 2 1 1 3 3 3 1 Fcf1 TIP49 PF06068.8 CCF36305.1 - 2.1e-187 622.7 0.2 2.4e-187 622.5 0.1 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 CCF36305.1 - 1.7e-11 44.4 0.2 6.6e-07 29.5 0.1 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 CCF36305.1 - 1.1e-09 37.7 0.1 2.3e-06 26.8 0.0 3.1 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 CCF36305.1 - 1.3e-05 24.8 0.3 4.1e-05 23.2 0.2 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 CCF36305.1 - 0.00029 20.9 0.3 0.74 9.9 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_16 PF13191.1 CCF36305.1 - 0.00052 20.0 0.0 0.18 11.7 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_28 PF13521.1 CCF36305.1 - 0.0015 18.5 0.1 0.0026 17.7 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 CCF36305.1 - 0.0033 16.8 0.0 0.016 14.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 CCF36305.1 - 0.0054 16.4 0.1 0.15 11.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 CCF36305.1 - 0.0055 15.8 0.3 0.014 14.5 0.2 1.6 1 0 0 1 1 1 1 Zeta toxin DUF2075 PF09848.4 CCF36305.1 - 0.012 14.5 0.1 0.037 13.0 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Sigma54_activat PF00158.21 CCF36305.1 - 0.013 14.9 0.1 0.76 9.2 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_18 PF13238.1 CCF36305.1 - 0.02 15.1 0.1 0.041 14.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 CCF36305.1 - 0.023 13.8 0.1 0.67 9.0 0.1 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 CCF36305.1 - 0.037 13.4 0.2 0.084 12.2 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein DnaB_C PF03796.10 CCF36305.1 - 0.042 12.7 0.0 0.083 11.7 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_17 PF13207.1 CCF36305.1 - 0.095 13.5 0.1 0.22 12.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain ResIII PF04851.10 CCF36305.1 - 0.15 11.8 0.2 3.1 7.5 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit EamA PF00892.15 CCF36306.1 - 1.6e-19 70.1 18.7 3.3e-10 40.0 1.6 2.7 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 CCF36306.1 - 0.00036 19.5 0.4 0.00036 19.5 0.3 2.2 2 0 0 2 2 2 2 UAA transporter family EmrE PF13536.1 CCF36306.1 - 0.0016 18.6 3.7 0.0016 18.6 2.5 3.6 2 1 1 3 3 3 1 Multidrug resistance efflux transporter Aa_trans PF01490.13 CCF36307.1 - 9.6e-29 100.0 30.7 1.3e-28 99.6 21.3 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Shisa PF13908.1 CCF36307.1 - 2.5 8.2 5.7 12 5.9 0.3 2.8 3 0 0 3 3 3 0 Wnt and FGF inhibitory regulator p450 PF00067.17 CCF36308.1 - 3.5e-73 246.7 0.0 4.2e-73 246.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ABC_cobalt PF09819.4 CCF36308.1 - 0.027 14.4 0.3 0.062 13.2 0.2 1.5 1 0 0 1 1 1 0 ABC-type cobalt transport system, permease component ComX PF05952.7 CCF36308.1 - 0.11 12.0 0.1 0.48 9.9 0.0 1.9 2 0 0 2 2 2 0 Bacillus competence pheromone ComX XLF PF09302.6 CCF36311.1 - 3.8e-29 101.6 0.1 6e-29 101.0 0.1 1.3 1 0 0 1 1 1 1 XLF (XRCC4-like factor) HATPase_c PF02518.21 CCF36313.1 - 1.7e-22 79.2 0.1 3.2e-22 78.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 CCF36313.1 - 7.5e-21 74.2 0.1 1.5e-20 73.2 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain PAS_9 PF13426.1 CCF36313.1 - 2.1e-11 44.1 0.0 5e-10 39.6 0.0 2.6 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.5 CCF36313.1 - 8.5e-09 35.4 0.0 0.0032 17.5 0.0 2.9 3 0 0 3 3 3 2 PAS fold HisKA PF00512.20 CCF36313.1 - 2.3e-08 33.8 0.2 6.2e-08 32.5 0.1 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF_2 PF13185.1 CCF36313.1 - 3.3e-07 30.9 0.0 0.001 19.5 0.0 2.7 2 0 0 2 2 2 2 GAF domain PAS_3 PF08447.6 CCF36313.1 - 0.00018 21.5 0.0 0.00059 19.8 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS PF00989.19 CCF36313.1 - 0.0013 18.5 0.0 0.0056 16.4 0.0 2.2 2 0 0 2 2 2 1 PAS fold GAF_3 PF13492.1 CCF36313.1 - 0.0018 18.3 0.0 0.005 16.9 0.0 1.8 1 0 0 1 1 1 1 GAF domain Aldo_ket_red PF00248.16 CCF36317.1 - 1.7e-53 181.2 0.0 2.1e-53 181.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Epimerase PF01370.16 CCF36318.1 - 4.4e-23 81.9 0.0 5.4e-23 81.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF36318.1 - 2.6e-14 52.5 0.0 3.2e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 CCF36318.1 - 7e-10 38.2 0.1 2.4e-05 23.3 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.1 CCF36318.1 - 1.1e-08 35.3 0.1 1.5e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 NADH(P)-binding RmlD_sub_bind PF04321.12 CCF36318.1 - 8.9e-08 31.3 0.0 1.4e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.20 CCF36318.1 - 1.8e-06 27.9 0.6 9.5e-06 25.6 0.1 2.3 2 1 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 CCF36318.1 - 4.7e-05 23.1 0.1 0.00011 21.9 0.0 1.6 1 1 0 1 1 1 1 KR domain NmrA PF05368.8 CCF36318.1 - 0.00042 19.6 0.1 0.012 14.8 0.0 2.1 2 0 0 2 2 2 1 NmrA-like family Ldh_1_N PF00056.18 CCF36318.1 - 0.013 15.3 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 CCF36318.1 - 0.039 12.9 0.0 0.054 12.4 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase Polysacc_synt_2 PF02719.10 CCF36318.1 - 0.05 12.4 0.0 0.17 10.7 0.0 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein DapB_N PF01113.15 CCF36318.1 - 0.11 12.3 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus FMN_dh PF01070.13 CCF36319.1 - 3.2e-115 384.8 0.0 4e-115 384.4 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 CCF36319.1 - 7.5e-19 67.3 0.0 1.4e-18 66.4 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ThiG PF05690.9 CCF36319.1 - 0.00032 19.8 0.1 0.015 14.3 0.0 2.4 1 1 1 2 2 2 1 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.12 CCF36319.1 - 0.00033 19.6 0.0 0.0007 18.6 0.0 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.10 CCF36319.1 - 0.0035 16.5 0.0 0.0062 15.7 0.0 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 CCF36319.1 - 0.0058 15.5 0.2 0.015 14.1 0.1 1.7 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain TMP-TENI PF02581.12 CCF36319.1 - 0.1 11.7 0.0 0.29 10.2 0.0 1.8 1 0 0 1 1 1 0 Thiamine monophosphate synthase/TENI DHDPS PF00701.17 CCF36320.1 - 8.4e-18 63.9 0.0 9.6e-18 63.7 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family MRP_L53 PF10780.4 CCF36321.1 - 7.9e-20 70.5 0.8 9.9e-20 70.2 0.5 1.1 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 Sec20 PF03908.8 CCF36322.1 - 2.6e-14 52.6 0.7 8.1e-14 51.1 0.0 2.1 2 0 0 2 2 2 1 Sec20 G5 PF07501.7 CCF36322.1 - 0.043 13.7 0.1 0.14 12.1 0.1 1.9 1 0 0 1 1 1 0 G5 domain STAT_alpha PF01017.15 CCF36322.1 - 0.057 13.1 2.7 0.54 9.9 0.0 2.6 2 1 0 2 2 2 0 STAT protein, all-alpha domain PEP-utilisers_N PF05524.8 CCF36322.1 - 0.38 10.5 4.4 9.4 6.0 2.4 3.1 2 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal CompInhib_SCIN PF11546.3 CCF36323.1 - 0.2 11.4 0.6 0.25 11.2 0.4 1.1 1 0 0 1 1 1 0 Staphylococcal complement inhibitor SCIN Peptidase_S8 PF00082.17 CCF36324.1 - 1.5e-43 148.9 2.8 5.4e-42 143.8 2.0 2.2 1 1 0 1 1 1 1 Subtilase family DUF1034 PF06280.7 CCF36324.1 - 1.8e-10 41.2 0.1 5.6e-10 39.6 0.1 1.9 1 0 0 1 1 1 1 Fn3-like domain (DUF1034) FlgD_ig PF13860.1 CCF36324.1 - 0.032 13.9 0.2 0.13 12.0 0.0 2.1 2 0 0 2 2 2 0 FlgD Ig-like domain MFS_1 PF07690.11 CCF36326.1 - 1.6e-12 46.8 20.6 1.8e-12 46.6 14.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF36326.1 - 0.13 10.7 14.5 0.061 11.8 8.0 1.7 1 1 1 2 2 2 0 Sugar (and other) transporter MFS_2 PF13347.1 CCF36326.1 - 0.86 7.9 15.0 0.87 7.9 8.5 1.9 1 1 1 2 2 2 0 MFS/sugar transport protein Trp_halogenase PF04820.9 CCF36327.1 - 8.1e-28 97.2 0.0 8.1e-15 54.3 0.0 2.2 1 1 1 2 2 2 2 Tryptophan halogenase FAD_binding_3 PF01494.14 CCF36327.1 - 8.5e-11 41.5 0.0 2.3e-10 40.0 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 CCF36327.1 - 1.9e-06 27.9 0.0 3.9e-06 26.8 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF36327.1 - 3.8e-05 23.6 0.1 0.00015 21.6 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF36327.1 - 0.00011 21.2 0.4 0.00045 19.2 0.1 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 CCF36327.1 - 0.0002 20.5 0.8 0.00037 19.6 0.6 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CCF36327.1 - 0.00035 19.5 0.1 0.0006 18.7 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.17 CCF36327.1 - 0.0011 17.8 0.1 0.002 17.0 0.1 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.9 CCF36327.1 - 0.0012 17.3 0.1 0.0018 16.7 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein ThiF PF00899.16 CCF36327.1 - 0.0059 16.4 0.3 0.17 11.6 0.2 2.9 3 0 0 3 3 3 1 ThiF family Thi4 PF01946.12 CCF36327.1 - 0.074 12.1 0.1 0.21 10.6 0.0 1.7 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.1 CCF36327.1 - 0.076 13.0 0.1 0.18 11.8 0.1 1.7 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF36327.1 - 0.076 13.4 0.1 0.16 12.3 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Peptidase_S9 PF00326.16 CCF36328.1 - 0.00067 18.9 0.0 0.00093 18.4 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 CCF36328.1 - 0.0014 18.5 0.0 0.0017 18.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF36328.1 - 0.037 13.7 0.0 0.041 13.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 CCF36328.1 - 0.049 13.2 0.0 0.078 12.5 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2205 PF10224.4 CCF36329.1 - 7.9e-31 105.4 0.2 1.4e-30 104.6 0.2 1.4 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) AAA_32 PF13654.1 CCF36329.1 - 0.014 14.1 0.2 0.018 13.7 0.2 1.1 1 0 0 1 1 1 0 AAA domain Nramp PF01566.13 CCF36331.1 - 3.8e-80 269.3 12.3 4.9e-80 269.0 8.5 1.1 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein SMK-1 PF04802.10 CCF36332.1 - 5e-80 267.5 0.7 8.3e-80 266.8 0.5 1.4 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 Chlam_vir PF05475.6 CCF36332.1 - 0.12 11.4 0.0 0.21 10.6 0.0 1.3 1 0 0 1 1 1 0 Chlamydia virulence protein PGP3-D TPR_7 PF13176.1 CCF36333.1 - 0.00094 18.8 1.1 3.4 7.6 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat PPR_3 PF13812.1 CCF36333.1 - 0.012 15.8 0.8 0.5 10.7 0.0 4.2 4 0 0 4 4 4 0 Pentatricopeptide repeat domain Poxvirus PF06227.7 CCF36333.1 - 0.11 12.0 0.1 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 dsDNA Poxvirus Zn_clus PF00172.13 CCF36335.1 - 1.7e-07 31.0 11.8 3.1e-07 30.1 8.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF36335.1 - 0.00015 20.7 0.1 0.00025 20.0 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2013 PF09431.5 CCF36336.1 - 4.1e-51 172.4 6.4 5.3e-51 172.0 1.5 2.5 2 1 1 3 3 3 1 Protein of unknown function (DUF2013) TMEM173 PF15009.1 CCF36337.1 - 0.12 11.1 0.2 0.15 10.8 0.2 1.1 1 0 0 1 1 1 0 Transmembrane protein 173 DUF2279 PF10043.4 CCF36339.1 - 0.023 14.9 0.0 0.048 13.9 0.0 1.5 1 0 0 1 1 1 0 Predicted periplasmic lipoprotein (DUF2279) Kinesin PF00225.18 CCF36340.1 - 1.3e-113 379.0 0.0 2.2e-113 378.4 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain DUF3782 PF12644.2 CCF36340.1 - 0.062 13.0 1.6 0.21 11.3 1.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3782) PUL PF08324.6 CCF36341.1 - 7.6e-39 133.1 0.0 1.2e-38 132.4 0.0 1.2 1 0 0 1 1 1 1 PUL domain Peptidase_C97 PF05903.9 CCF36341.1 - 1.1e-33 116.0 0.0 1.8e-33 115.4 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain Thioredoxin PF00085.15 CCF36341.1 - 1.4e-11 44.0 0.0 2.9e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.1 CCF36341.1 - 0.00045 19.7 0.0 0.00078 18.9 0.0 1.3 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_9 PF14595.1 CCF36341.1 - 0.01 15.3 0.0 0.019 14.5 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_2 PF13098.1 CCF36341.1 - 0.018 15.2 0.0 0.054 13.7 0.0 1.8 1 1 0 1 1 1 0 Thioredoxin-like domain Redoxin PF08534.5 CCF36341.1 - 0.028 13.9 0.1 0.054 13.0 0.0 1.4 1 0 0 1 1 1 0 Redoxin Tox-PL-2 PF15643.1 CCF36341.1 - 0.13 12.2 0.0 1.9 8.4 0.0 2.6 2 1 1 3 3 3 0 Papain fold toxin 2 DUF4524 PF15025.1 CCF36341.1 - 0.17 11.3 0.6 8.8 5.8 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4524) GDA1_CD39 PF01150.12 CCF36342.1 - 4.8e-98 328.4 0.0 5.8e-98 328.2 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.11 CCF36342.1 - 0.032 13.4 0.0 0.055 12.6 0.0 1.3 1 0 0 1 1 1 0 Ppx/GppA phosphatase family Ras PF00071.17 CCF36344.1 - 4.3e-57 192.0 0.0 5.1e-57 191.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF36344.1 - 1.4e-18 67.5 0.0 2.1e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CCF36344.1 - 2.8e-13 49.4 0.0 3.4e-13 49.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 CCF36344.1 - 1.6e-07 31.2 0.0 2.2e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 CCF36344.1 - 8.5e-07 28.3 0.0 1e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 CCF36344.1 - 2.2e-06 27.2 0.0 4.4e-05 22.9 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 CCF36344.1 - 0.00067 19.7 0.0 0.0015 18.7 0.0 1.4 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 CCF36344.1 - 0.00099 18.3 0.1 0.0019 17.4 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_5 PF07728.9 CCF36344.1 - 0.0018 17.9 0.0 0.0064 16.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) SRPRB PF09439.5 CCF36344.1 - 0.002 17.3 0.0 0.0026 17.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.1 CCF36344.1 - 0.0039 17.1 0.0 0.011 15.7 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.1 CCF36344.1 - 0.0043 16.6 0.1 0.0077 15.8 0.1 1.4 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 CCF36344.1 - 0.0054 16.4 0.1 0.01 15.5 0.0 1.5 2 0 0 2 2 2 1 Archaeal ATPase PduV-EutP PF10662.4 CCF36344.1 - 0.0064 15.9 0.0 0.1 12.1 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_10 PF12846.2 CCF36344.1 - 0.0075 15.7 0.2 0.012 15.0 0.1 1.4 1 1 0 1 1 1 1 AAA-like domain ATP_bind_1 PF03029.12 CCF36344.1 - 0.0079 15.7 0.3 0.28 10.6 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Septin PF00735.13 CCF36344.1 - 0.014 14.4 0.1 0.032 13.2 0.0 1.7 2 0 0 2 2 2 0 Septin NTPase_1 PF03266.10 CCF36344.1 - 0.022 14.4 0.0 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 NTPase MobB PF03205.9 CCF36344.1 - 0.023 14.4 0.1 0.058 13.1 0.0 1.7 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.14 CCF36344.1 - 0.033 13.6 0.0 0.076 12.4 0.0 1.6 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.17 CCF36344.1 - 0.07 11.9 0.2 0.35 9.6 0.1 1.9 2 0 0 2 2 2 0 NB-ARC domain NACHT PF05729.7 CCF36344.1 - 0.086 12.4 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 NACHT domain FeoB_N PF02421.13 CCF36344.1 - 0.091 12.0 0.0 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B RNA_helicase PF00910.17 CCF36344.1 - 0.12 12.5 0.0 0.43 10.7 0.0 1.9 2 0 0 2 2 2 0 RNA helicase EamA PF00892.15 CCF36345.1 - 8.1e-07 29.1 33.1 1.8e-05 24.7 4.2 3.0 3 0 0 3 3 3 2 EamA-like transporter family DUF914 PF06027.7 CCF36345.1 - 1.3e-06 27.4 8.2 1.3e-06 27.4 5.7 2.0 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF914) TPT PF03151.11 CCF36345.1 - 0.00029 20.4 27.3 0.00053 19.6 2.7 3.2 3 0 0 3 3 3 2 Triose-phosphate Transporter family UAA PF08449.6 CCF36345.1 - 0.00039 19.4 16.3 0.00042 19.3 9.1 1.9 2 0 0 2 2 2 1 UAA transporter family EmrE PF13536.1 CCF36345.1 - 0.0021 18.2 4.8 0.0021 18.2 3.4 3.7 3 2 0 3 3 3 1 Multidrug resistance efflux transporter DUF1003 PF06210.6 CCF36345.1 - 3.7 7.5 5.7 1.4 8.8 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) Choline_transpo PF04515.7 CCF36346.1 - 1.2e-09 37.4 21.5 1.2e-09 37.4 14.9 3.2 3 0 0 3 3 3 2 Plasma-membrane choline transporter GST_N_3 PF13417.1 CCF36347.1 - 9.9e-14 51.3 0.0 1.8e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 CCF36347.1 - 1e-11 44.8 0.0 2.3e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 CCF36347.1 - 8.1e-11 41.7 0.0 1.8e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 CCF36347.1 - 3.9e-10 39.4 0.2 7.3e-10 38.6 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 CCF36347.1 - 2.2e-08 33.9 0.1 4.1e-08 33.0 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 CCF36347.1 - 2e-07 31.4 0.3 3.8e-07 30.5 0.2 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain MetRS-N PF09635.5 CCF36347.1 - 0.12 12.7 0.0 0.26 11.6 0.0 1.6 1 0 0 1 1 1 0 MetRS-N binding domain Glyco_hydro_3 PF00933.16 CCF36349.1 - 3.1e-84 282.4 0.0 4.1e-84 282.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 CCF36349.1 - 2.8e-30 105.5 0.0 4.1e-30 105.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Lipase_GDSL PF00657.17 CCF36350.1 - 2.2e-13 50.5 0.2 3.2e-13 50.0 0.2 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.1 CCF36350.1 - 2.6e-12 47.2 0.4 3.4e-12 46.8 0.3 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL_3 PF14606.1 CCF36350.1 - 4.4e-06 26.5 0.0 6.8e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Tachystatin_B PF11478.3 CCF36351.1 - 0.16 11.6 1.3 0.24 11.1 0.9 1.4 1 1 0 1 1 1 0 Antimicrobial chitin binding protein tachystatin B Cupin_2 PF07883.6 CCF36353.1 - 1.8e-21 75.3 1.3 1.7e-18 65.8 0.1 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_1 PF00190.17 CCF36353.1 - 0.00045 19.6 0.0 0.026 13.9 0.0 2.2 2 0 0 2 2 2 1 Cupin AraC_binding PF02311.14 CCF36353.1 - 0.00046 19.8 0.3 0.001 18.7 0.2 1.6 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_3 PF05899.7 CCF36353.1 - 0.0026 17.0 0.0 0.05 12.9 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF861) FAA_hydrolase PF01557.13 CCF36354.1 - 9.4e-31 106.9 0.0 1.6e-30 106.1 0.0 1.4 2 0 0 2 2 2 1 Fumarylacetoacetate (FAA) hydrolase family QPP PF07640.6 CCF36356.1 - 0.019 14.5 4.6 0.077 12.6 3.2 2.1 1 0 0 1 1 1 0 QPP DUF904 PF06005.7 CCF36356.1 - 0.16 12.2 2.6 0.39 11.0 1.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF904) BSP PF04450.7 CCF36359.1 - 6.2e-76 254.4 0.0 7.4e-76 254.1 0.0 1.0 1 0 0 1 1 1 1 Peptidase of plants and bacteria Peptidase_MA_2 PF13485.1 CCF36359.1 - 2.1e-07 30.9 0.4 2.5e-06 27.5 0.3 2.1 1 1 0 1 1 1 1 Peptidase MA superfamily SprT-like PF10263.4 CCF36359.1 - 0.0049 16.5 0.1 0.0074 15.9 0.0 1.3 1 0 0 1 1 1 1 SprT-like family CLASP_N PF12348.3 CCF36360.1 - 3.8e-138 458.2 0.0 2.3e-89 298.6 0.0 2.1 2 0 0 2 2 2 2 CLASP N terminal HEAT PF02985.17 CCF36360.1 - 0.00018 21.2 0.0 4 7.7 0.0 4.6 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.1 CCF36360.1 - 0.079 13.2 0.0 3.1 8.1 0.0 3.3 2 1 0 2 2 2 0 HEAT repeats HEAT_EZ PF13513.1 CCF36360.1 - 0.093 13.2 0.0 35 5.0 0.0 3.6 4 0 0 4 4 4 0 HEAT-like repeat DUF3328 PF11807.3 CCF36362.1 - 0.0046 16.6 0.2 0.99 9.0 0.0 3.0 3 0 0 3 3 3 2 Domain of unknown function (DUF3328) DUF3328 PF11807.3 CCF36363.1 - 3.9e-14 52.8 0.2 6.3e-14 52.1 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) ketoacyl-synt PF00109.21 CCF36364.1 - 3.8e-42 144.5 2.5 5.9e-40 137.3 1.7 2.2 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain FAE1_CUT1_RppA PF08392.7 CCF36364.1 - 0.026 13.5 1.4 0.037 13.0 1.0 1.2 1 0 0 1 1 1 0 FAE1/Type III polyketide synthase-like protein Thiolase_N PF00108.18 CCF36364.1 - 0.042 12.8 0.4 0.07 12.1 0.2 1.3 1 0 0 1 1 1 0 Thiolase, N-terminal domain ACP_syn_III PF08545.5 CCF36364.1 - 0.096 12.3 1.2 0.26 10.9 0.9 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Cu-oxidase_3 PF07732.10 CCF36366.1 - 2.1e-37 127.4 0.4 1e-36 125.1 0.3 2.2 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 CCF36366.1 - 2.4e-22 78.9 6.2 5.5e-17 61.5 0.2 4.0 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 CCF36366.1 - 3.7e-17 62.6 0.1 1e-16 61.2 0.0 1.8 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.17 CCF36367.1 - 1.2e-16 61.0 0.0 2e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 CCF36367.1 - 7.2e-10 38.5 0.0 0.00057 19.4 0.0 2.3 2 0 0 2 2 2 2 Multicopper oxidase FTZ PF03867.9 CCF36367.1 - 0.12 11.5 0.6 0.23 10.6 0.4 1.4 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region PhyH PF05721.8 CCF36368.1 - 1e-13 51.8 0.0 5.4e-13 49.4 0.0 1.9 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) CENP-O PF09496.5 CCF36370.1 - 0.14 12.3 0.0 2.2 8.5 0.0 2.6 1 1 0 1 1 1 0 Cenp-O kinetochore centromere component Zn_clus PF00172.13 CCF36370.1 - 1.8 8.5 8.1 4.6 7.2 5.6 1.7 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DAO PF01266.19 CCF36371.1 - 2.8e-44 151.4 0.0 4.1e-44 150.9 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 CCF36371.1 - 1e-06 28.6 0.2 0.017 14.8 0.0 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 CCF36371.1 - 3.1e-06 27.2 0.9 0.00092 19.1 0.7 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF36371.1 - 0.00014 20.9 0.1 0.03 13.2 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Trp_halogenase PF04820.9 CCF36371.1 - 0.0013 17.4 0.2 0.3 9.6 0.1 2.2 2 0 0 2 2 2 2 Tryptophan halogenase GIDA PF01134.17 CCF36371.1 - 0.0024 16.8 0.2 0.0067 15.3 0.0 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.1 CCF36371.1 - 0.0042 17.0 0.0 0.014 15.4 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF36371.1 - 0.0085 16.1 0.2 0.26 11.3 0.1 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 CCF36371.1 - 0.033 14.4 0.0 0.056 13.7 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Amino_oxidase PF01593.19 CCF36371.1 - 0.058 12.4 0.0 0.098 11.7 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Transp_cyt_pur PF02133.10 CCF36372.1 - 3e-79 266.6 41.2 3.4e-79 266.4 28.6 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Pmp3 PF01679.12 CCF36373.1 - 6e-20 70.6 7.7 7.9e-20 70.3 5.3 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator CoxIIa PF08113.6 CCF36373.1 - 0.18 11.5 5.4 0.092 12.4 1.5 2.0 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IIa family NapE PF06796.6 CCF36373.1 - 0.58 9.5 2.1 0.84 8.9 1.5 1.3 1 0 0 1 1 1 0 Periplasmic nitrate reductase protein NapE Chitin_bind_3 PF03067.10 CCF36375.1 - 2e-08 34.7 0.1 3.1e-08 34.0 0.1 1.3 1 1 0 1 1 1 1 Chitin binding domain CFEM PF05730.6 CCF36376.1 - 2.5e-13 49.6 7.9 4.2e-13 48.9 5.5 1.4 1 0 0 1 1 1 1 CFEM domain Fungal_trans PF04082.13 CCF36379.1 - 3.4e-25 88.3 1.1 5.9e-25 87.6 0.7 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF36379.1 - 6.2e-08 32.4 12.3 1.3e-07 31.4 8.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BBE PF08031.7 CCF36380.1 - 3.4e-08 33.2 0.0 5.3e-08 32.6 0.0 1.4 1 1 0 1 1 1 1 Berberine and berberine like Cytokin-bind PF09265.5 CCF36380.1 - 0.016 14.3 0.2 0.018 14.2 0.1 1.1 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding DUF953 PF06110.6 CCF36380.1 - 0.053 12.9 0.3 0.069 12.5 0.2 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Med12 PF09497.5 CCF36381.1 - 2.7e-27 94.5 0.3 7.5e-27 93.1 0.2 1.9 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Med12-LCEWAV PF12145.3 CCF36381.1 - 0.16 10.4 0.0 3.8 5.8 0.0 2.2 1 1 1 2 2 2 0 Eukaryotic Mediator 12 subunit domain Cellulase PF00150.13 CCF36383.1 - 2.9e-19 69.3 0.4 3.9e-19 68.9 0.3 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.12 CCF36383.1 - 0.00042 19.3 0.0 0.0013 17.7 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_42 PF02449.10 CCF36383.1 - 0.0017 17.5 0.1 0.0038 16.3 0.0 1.6 2 0 0 2 2 2 1 Beta-galactosidase Cellulase-like PF12876.2 CCF36383.1 - 0.0079 16.6 0.0 0.018 15.5 0.0 1.6 1 0 0 1 1 1 1 Sugar-binding cellulase-like Glyco_hydro_10 PF00331.15 CCF36383.1 - 0.046 12.7 0.1 0.082 11.9 0.0 1.4 1 1 0 1 1 1 0 Glycosyl hydrolase family 10 DUF2255 PF10012.4 CCF36383.1 - 0.064 13.2 0.2 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2255) tRNA-synt_2b PF00587.20 CCF36384.1 - 8.3e-68 227.3 0.0 6.5e-67 224.4 0.1 2.1 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 CCF36384.1 - 3.6e-21 74.9 5.3 5.2e-21 74.4 0.1 3.2 3 0 0 3 3 3 1 Anticodon binding domain DUF2346 PF09803.4 CCF36384.1 - 0.0088 15.8 1.5 0.024 14.4 1.0 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2346) DUF3742 PF12553.3 CCF36385.1 - 0.05 14.0 0.0 0.36 11.3 0.0 2.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3742) HIRAN PF08797.6 CCF36386.1 - 0.0024 17.7 0.0 0.0049 16.7 0.0 1.6 1 1 0 1 1 1 1 HIRAN domain R3H PF01424.17 CCF36387.1 - 1.3e-09 37.6 0.3 2.5e-09 36.6 0.2 1.5 1 0 0 1 1 1 1 R3H domain RRM_6 PF14259.1 CCF36387.1 - 6e-07 29.3 0.1 1e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CCF36387.1 - 1.6e-05 24.4 0.0 4.8e-05 22.9 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF36387.1 - 0.00024 20.8 0.0 0.00042 20.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_2 PF04059.7 CCF36387.1 - 0.053 13.5 0.0 0.088 12.8 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif 2 Peptidase_S8 PF00082.17 CCF36389.1 - 1.7e-28 99.5 0.4 2.5e-28 99.0 0.3 1.3 1 0 0 1 1 1 1 Subtilase family PA PF02225.17 CCF36389.1 - 5.9e-08 32.3 0.2 3.5e-07 29.8 0.0 2.3 2 0 0 2 2 2 1 PA domain Inhibitor_I9 PF05922.11 CCF36389.1 - 0.039 14.5 0.0 0.077 13.5 0.0 1.5 1 0 0 1 1 1 0 Peptidase inhibitor I9 Sugar_tr PF00083.19 CCF36390.1 - 2.9e-39 134.9 19.9 4.1e-39 134.4 13.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF36390.1 - 4.2e-32 111.2 29.1 1.1e-25 90.1 9.7 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily zf-C2H2_4 PF13894.1 CCF36392.1 - 9.3e-09 35.0 11.3 0.00059 19.9 0.3 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF36392.1 - 4.4e-07 29.8 11.3 0.00026 21.1 1.0 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-met PF12874.2 CCF36392.1 - 0.024 14.8 0.1 39 4.6 0.0 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.1 CCF36392.1 - 0.041 14.1 8.0 0.24 11.7 0.2 3.3 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_jaz PF12171.3 CCF36392.1 - 0.058 13.5 1.2 20 5.4 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding IBR PF01485.16 CCF36392.1 - 0.32 10.8 0.1 0.32 10.8 0.1 2.2 2 1 0 2 2 2 0 IBR domain zf-TRAF PF02176.13 CCF36392.1 - 1.4 9.3 6.8 0.36 11.2 0.2 2.8 1 1 1 3 3 3 0 TRAF-type zinc finger Acetyltransf_3 PF13302.1 CCF36394.1 - 4.3e-25 88.5 0.0 5e-25 88.3 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CCF36394.1 - 5.9e-07 29.4 0.1 9.7e-07 28.7 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 CCF36394.1 - 0.0098 15.8 0.0 0.025 14.5 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain adh_short_C2 PF13561.1 CCF36397.1 - 1.9e-13 50.7 0.6 3.2e-08 33.6 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF36397.1 - 5.1e-10 39.5 1.2 9.5e-10 38.6 0.7 1.5 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF36397.1 - 7.2e-07 29.0 0.4 1.2e-06 28.3 0.3 1.4 1 0 0 1 1 1 1 KR domain Saccharop_dh PF03435.13 CCF36397.1 - 7.5e-06 25.1 0.2 1.3e-05 24.3 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase Acyl-CoA_dh_1 PF00441.19 CCF36397.1 - 0.015 15.3 0.3 0.032 14.3 0.2 1.5 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain DAO PF01266.19 CCF36397.1 - 0.61 8.9 4.7 0.99 8.2 3.1 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase Peptidase_S28 PF05577.7 CCF36399.1 - 1.1e-50 172.5 0.0 6.4e-36 123.8 0.0 2.0 2 0 0 2 2 2 2 Serine carboxypeptidase S28 HlyD PF00529.15 CCF36400.1 - 0.1 11.8 5.9 0.17 11.1 4.1 1.3 1 0 0 1 1 1 0 HlyD family secretion protein HSP70 PF00012.15 CCF36400.1 - 0.15 9.9 2.6 0.21 9.4 1.8 1.1 1 0 0 1 1 1 0 Hsp70 protein DNA_methylase PF00145.12 CCF36401.1 - 2.1e-39 135.5 0.0 2.4e-28 99.2 0.0 2.4 1 1 1 2 2 2 2 C-5 cytosine-specific DNA methylase Pectinesterase PF01095.14 CCF36402.1 - 1.9e-29 102.2 0.3 3.1e-24 85.0 0.9 2.1 2 0 0 2 2 2 2 Pectinesterase Nuc_sug_transp PF04142.10 CCF36405.1 - 3.7e-26 91.7 14.4 9.5e-26 90.3 10.0 1.6 1 1 0 1 1 1 1 Nucleotide-sugar transporter EmrE PF13536.1 CCF36405.1 - 0.035 14.3 0.8 0.035 14.3 0.5 3.2 3 0 0 3 3 3 0 Multidrug resistance efflux transporter Gate PF07670.9 CCF36405.1 - 0.036 13.9 0.0 0.036 13.9 0.0 2.8 3 1 0 3 3 3 0 Nucleoside recognition Pkinase PF00069.20 CCF36406.1 - 6e-59 199.2 0.1 7e-59 199.0 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF36406.1 - 1.4e-18 66.8 0.0 2.1e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CCF36406.1 - 8.1e-08 32.2 0.1 1.1e-05 25.2 0.1 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CCF36406.1 - 0.0047 16.5 0.4 0.011 15.3 0.3 1.7 1 1 0 1 1 1 1 Choline/ethanolamine kinase Kinase-like PF14531.1 CCF36406.1 - 0.025 13.5 0.0 0.04 12.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.9 CCF36406.1 - 0.047 12.7 0.0 0.068 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Aconitase_B_N PF11791.3 CCF36406.1 - 0.069 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Aconitate B N-terminal domain DUF3807 PF12720.2 CCF36407.1 - 3.3e-35 121.7 2.5 3.9e-35 121.5 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3807) GAGA_bind PF06217.7 CCF36407.1 - 0.041 13.8 0.1 0.041 13.8 0.1 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family EPL1 PF10513.4 CCF36407.1 - 0.066 13.4 0.2 0.096 12.9 0.1 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like MFS_1 PF07690.11 CCF36409.1 - 5.2e-27 94.4 16.9 5.2e-27 94.4 11.7 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Cation_ATPase_C PF00689.16 CCF36409.1 - 0.57 9.6 0.0 0.57 9.6 0.0 3.3 3 1 2 5 5 5 0 Cation transporting ATPase, C-terminus Alk_phosphatase PF00245.15 CCF36410.1 - 1.6e-84 284.0 0.0 2e-84 283.7 0.0 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Methyltransf_23 PF13489.1 CCF36411.1 - 8.9e-17 61.2 0.1 1.1e-16 60.9 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF36411.1 - 9e-13 48.5 0.0 2e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF36411.1 - 8.3e-12 45.4 0.1 2.2e-11 44.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF36411.1 - 2e-11 44.4 0.0 5e-11 43.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF36411.1 - 2.4e-11 43.4 0.0 4.8e-11 42.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF36411.1 - 2.7e-10 40.4 0.1 7.7e-10 39.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF36411.1 - 2.9e-09 36.4 0.0 4.8e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 CCF36411.1 - 6.7e-06 26.1 0.0 1.3e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 CCF36411.1 - 0.0047 16.6 0.0 0.011 15.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 CCF36411.1 - 0.027 13.8 0.0 0.15 11.4 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase small domain Acetyltransf_1 PF00583.19 CCF36412.1 - 1.1e-11 44.6 0.0 1.6e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF36412.1 - 1.3e-08 34.8 0.0 2.1e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CCF36412.1 - 1.5e-06 28.3 0.1 2.5e-06 27.6 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 CCF36412.1 - 0.004 17.0 0.0 0.024 14.4 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain MOZ_SAS PF01853.13 CCF36412.1 - 0.035 13.3 0.0 0.048 12.8 0.0 1.1 1 0 0 1 1 1 0 MOZ/SAS family FR47 PF08445.5 CCF36412.1 - 0.059 13.1 0.0 0.18 11.5 0.0 1.7 1 1 0 1 1 1 0 FR47-like protein WD40 PF00400.27 CCF36413.1 - 1.4e-06 27.9 12.2 0.19 11.6 0.0 6.2 7 0 0 7 7 7 4 WD domain, G-beta repeat AMP-binding PF00501.23 CCF36414.1 - 9.2e-81 271.3 0.0 1.1e-80 271.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme MARVEL PF01284.18 CCF36416.1 - 7.6e-20 71.1 15.8 9.2e-20 70.9 11.0 1.0 1 0 0 1 1 1 1 Membrane-associating domain DUF2650 PF10853.3 CCF36417.1 - 3.7 7.1 6.4 9.1 5.8 4.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2650) WD40 PF00400.27 CCF36418.1 - 2.7e-13 49.2 0.1 0.0014 18.4 0.0 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat Spb1_C PF07780.7 CCF36420.1 - 4.3e-76 255.1 22.6 4.3e-76 255.1 15.7 3.7 3 1 0 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.14 CCF36420.1 - 2e-55 187.5 0.0 4.1e-55 186.5 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.3 CCF36420.1 - 4.5e-53 178.9 9.9 4.5e-53 178.9 6.8 5.1 4 1 1 5 5 5 1 Domain of unknown function (DUF3381) Methyltransf_23 PF13489.1 CCF36420.1 - 0.00046 19.9 0.0 0.0057 16.3 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Metallopep PF12044.3 CCF36421.1 - 5.1e-162 539.1 0.0 6.9e-162 538.7 0.0 1.2 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.12 CCF36421.1 - 4.9e-05 23.2 0.0 0.00011 22.0 0.0 1.6 1 0 0 1 1 1 1 Jacalin-like lectin domain Reprolysin_5 PF13688.1 CCF36421.1 - 0.00047 20.1 0.2 0.0011 18.9 0.2 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.1 CCF36421.1 - 0.0025 17.9 0.2 0.0046 17.0 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.1 CCF36421.1 - 0.024 15.1 0.3 0.057 13.9 0.2 1.7 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF1795 PF08786.6 CCF36421.1 - 0.16 11.7 0.0 0.34 10.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1795) DUF3043 PF11241.3 CCF36422.1 - 0.0042 16.7 0.1 0.0067 16.0 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3043) zf-LITAF-like PF10601.4 CCF36422.1 - 8 6.4 6.0 4.6 7.1 2.9 1.5 1 1 0 1 1 1 0 LITAF-like zinc ribbon domain WW PF00397.21 CCF36423.1 - 3.1e-06 26.9 1.6 7.1e-06 25.7 1.1 1.6 1 0 0 1 1 1 1 WW domain Fungal_trans PF04082.13 CCF36424.1 - 2.9e-05 23.0 0.0 5.2e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2366 PF10171.4 CCF36424.1 - 0.075 12.5 0.0 0.41 10.1 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2366) GATA PF00320.22 CCF36425.1 - 1.7e-31 107.2 18.5 3.6e-17 61.3 2.3 2.6 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.7 CCF36425.1 - 9.2e-06 24.8 5.2 0.0074 15.5 0.3 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding ArfGap PF01412.13 CCF36425.1 - 0.0013 18.5 1.4 0.54 10.0 0.2 2.4 2 0 0 2 2 2 2 Putative GTPase activating protein for Arf RRN7 PF11781.3 CCF36425.1 - 0.0015 17.9 8.1 0.19 11.2 0.3 2.6 2 0 0 2 2 2 2 RNA polymerase I-specific transcription initiation factor Rrn7 Zn-ribbon_8 PF09723.5 CCF36425.1 - 0.041 13.8 6.6 1.2 9.1 0.1 2.9 3 0 0 3 3 2 0 Zinc ribbon domain zf-Sec23_Sec24 PF04810.10 CCF36425.1 - 0.047 13.2 0.5 0.047 13.2 0.3 3.1 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger Auto_anti-p27 PF06677.7 CCF36425.1 - 0.05 13.3 4.0 1.2 8.9 0.2 2.5 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) NMD3 PF04981.8 CCF36425.1 - 0.061 12.4 1.8 1.7 7.7 0.1 2.3 2 0 0 2 2 2 0 NMD3 family OrfB_Zn_ribbon PF07282.6 CCF36425.1 - 0.093 12.4 13.6 0.037 13.6 1.1 3.0 3 0 0 3 3 3 0 Putative transposase DNA-binding domain zf-ribbon_3 PF13248.1 CCF36425.1 - 0.2 10.8 10.7 0.37 10.0 0.2 3.2 2 1 0 2 2 2 0 zinc-ribbon domain Prim_Zn_Ribbon PF08273.7 CCF36425.1 - 0.5 10.4 14.8 3.8 7.6 2.2 3.4 2 2 1 3 3 3 0 Zinc-binding domain of primase-helicase Zn_Tnp_IS1595 PF12760.2 CCF36425.1 - 1.1 9.1 7.3 1.9 8.3 0.8 2.7 2 0 0 2 2 2 0 Transposase zinc-ribbon domain eIF-5_eIF-2B PF01873.12 CCF36425.1 - 2.3 7.8 6.7 7.1 6.3 0.4 2.4 2 0 0 2 2 2 0 Domain found in IF2B/IF5 zf-C2H2_3 PF13878.1 CCF36425.1 - 5.5 6.6 11.6 5.7 6.6 0.3 4.2 3 1 1 4 4 4 0 zinc-finger of acetyl-transferase ESCO HypA PF01155.14 CCF36425.1 - 7.6 6.2 7.9 3 7.5 0.1 2.8 3 0 0 3 3 3 0 Hydrogenase expression/synthesis hypA family COPI_assoc PF08507.5 CCF36426.1 - 4.2e-44 149.5 6.9 4.6e-44 149.4 4.8 1.0 1 0 0 1 1 1 1 COPI associated protein DUF1113 PF06541.6 CCF36426.1 - 0.0051 16.5 0.8 0.0072 16.1 0.4 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1113) Oxidored_q3 PF00499.15 CCF36426.1 - 0.052 13.3 11.5 0.068 12.9 8.0 1.2 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 UCR_Fe-S_N PF10399.4 CCF36426.1 - 0.084 12.0 1.3 0.09 11.9 0.0 1.7 2 0 0 2 2 2 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal DUF3784 PF12650.2 CCF36426.1 - 0.89 9.5 11.6 0.27 11.1 1.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) Neurensin PF14927.1 CCF36426.1 - 2.6 7.4 5.3 10 5.5 3.8 2.2 1 1 1 2 2 2 0 Neurensin Cg6151-P PF10233.4 CCF36426.1 - 3.4 7.6 10.8 18 5.3 7.3 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein CG6151-P DNA_ligase_A_M PF01068.16 CCF36427.1 - 5.3e-22 78.1 0.0 9.3e-22 77.3 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 CCF36427.1 - 1.4e-18 67.3 0.0 5.6e-18 65.3 0.0 2.0 2 0 0 2 2 2 1 DNA ligase N terminus 2OG-FeII_Oxy PF03171.15 CCF36428.1 - 3.2e-10 40.1 0.0 5.1e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Lipase_3 PF01764.20 CCF36429.1 - 1.2e-38 131.8 0.0 1.8e-38 131.2 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_8 PF06259.7 CCF36429.1 - 0.00026 20.5 0.4 0.00048 19.6 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase Cutinase PF01083.17 CCF36429.1 - 0.001 18.8 0.5 0.001 18.8 0.4 2.4 2 1 0 2 2 2 1 Cutinase Abhydrolase_5 PF12695.2 CCF36429.1 - 0.0025 17.5 0.0 0.0038 16.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.3 CCF36429.1 - 0.0048 16.2 0.5 0.012 14.9 0.3 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Esterase PF00756.15 CCF36429.1 - 0.005 16.3 0.0 0.0079 15.6 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.2 CCF36429.1 - 0.016 15.0 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.8 CCF36429.1 - 0.026 14.0 0.0 0.037 13.6 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Thioesterase PF00975.15 CCF36429.1 - 0.046 13.9 0.0 0.097 12.8 0.0 1.5 1 0 0 1 1 1 0 Thioesterase domain DUF676 PF05057.9 CCF36429.1 - 0.052 12.8 0.0 0.081 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Glyco_hydro_3 PF00933.16 CCF36430.1 - 4.3e-62 209.7 0.0 5.5e-62 209.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain GMC_oxred_N PF00732.14 CCF36431.1 - 4.2e-30 104.9 0.0 7.7e-30 104.0 0.0 1.4 2 0 0 2 2 2 1 GMC oxidoreductase Lycopene_cycl PF05834.7 CCF36431.1 - 0.00013 21.0 0.0 0.00016 20.7 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 CCF36431.1 - 0.00016 21.6 0.1 0.00049 20.0 0.1 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF36431.1 - 0.00043 19.2 0.1 0.00048 19.1 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF36431.1 - 0.0023 17.8 0.0 0.0028 17.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF36431.1 - 0.0026 16.6 0.0 0.0038 16.1 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 CCF36431.1 - 0.013 14.0 0.0 0.017 13.6 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.12 CCF36431.1 - 0.034 13.2 0.0 0.065 12.3 0.0 1.4 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.1 CCF36431.1 - 0.055 13.2 0.1 0.17 11.6 0.0 1.8 1 1 0 1 1 1 0 FAD-NAD(P)-binding TrkA_N PF02254.13 CCF36431.1 - 0.13 12.2 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain Trp_halogenase PF04820.9 CCF36431.1 - 0.13 10.8 0.0 0.19 10.2 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase GFA PF04828.9 CCF36432.1 - 2.2e-09 37.1 0.0 2.9e-07 30.3 0.0 2.1 2 0 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme WD40 PF00400.27 CCF36433.1 - 6.6e-10 38.4 0.1 8.1e-07 28.6 0.1 2.9 2 0 0 2 2 2 2 WD domain, G-beta repeat DUF2415 PF10313.4 CCF36433.1 - 2.3e-05 23.9 0.0 6.9e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) Vps51 PF08700.6 CCF36433.1 - 0.13 12.1 0.3 0.53 10.1 0.0 2.0 2 0 0 2 2 2 0 Vps51/Vps67 RXT2_N PF08595.6 CCF36433.1 - 3.8 7.3 5.3 2.4 7.9 2.2 1.7 2 0 0 2 2 2 0 RXT2-like, N-terminal Baculo_PEP_C PF04513.7 CCF36435.1 - 0.00059 19.6 9.8 0.052 13.3 1.3 3.6 2 1 1 3 3 3 3 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.7 CCF36435.1 - 8.2 6.7 14.9 2.4 8.4 0.1 4.9 4 2 1 5 5 5 0 Nucleopolyhedrovirus P10 protein Trp_syntA PF00290.15 CCF36436.1 - 4.6e-92 307.1 0.0 7.4e-92 306.5 0.0 1.3 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.20 CCF36436.1 - 8.8e-45 153.2 1.5 1.6e-44 152.3 1.0 1.4 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PcrB PF01884.12 CCF36436.1 - 0.063 12.5 0.1 4 6.6 0.0 2.6 2 0 0 2 2 2 0 PcrB family Ribosomal_L28 PF00830.14 CCF36437.1 - 2e-18 65.9 0.4 3.2e-18 65.3 0.3 1.3 1 0 0 1 1 1 1 Ribosomal L28 family DUF3439 PF11921.3 CCF36437.1 - 0.024 14.3 2.6 0.039 13.7 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Methyltransf_26 PF13659.1 CCF36438.1 - 2.5 8.1 4.6 1.4 8.9 0.2 2.6 1 1 1 2 2 2 0 Methyltransferase domain DUF3073 PF11273.3 CCF36438.1 - 5.5 7.5 8.5 0.48 10.9 0.2 3.3 5 0 0 5 5 5 0 Protein of unknown function (DUF3073) Aminotran_1_2 PF00155.16 CCF36439.1 - 2.4e-89 299.8 0.0 2.7e-89 299.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Dicty_REP PF05086.7 CCF36440.1 - 0.059 11.1 0.5 0.083 10.6 0.3 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Acetyltransf_1 PF00583.19 CCF36441.1 - 3.2e-06 27.0 0.1 6.5e-06 26.0 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF36441.1 - 0.0024 18.0 0.0 0.0053 16.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF36441.1 - 0.015 14.9 0.0 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 FR47-like protein Acyl-thio_N PF12590.3 CCF36442.1 - 0.2 12.1 2.8 0.15 12.5 0.4 1.9 2 1 1 3 3 3 0 Acyl-ATP thioesterase ResIII PF04851.10 CCF36443.1 - 7e-22 78.1 0.0 1.4e-21 77.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 CCF36443.1 - 2.8e-21 75.7 0.2 2.2e-20 72.8 0.0 2.3 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF36443.1 - 2.7e-20 72.0 0.0 6.2e-20 70.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 CCF36443.1 - 0.0015 18.6 0.0 0.011 15.9 0.0 2.2 1 1 1 2 2 2 1 AAA domain Peptidase_M14 PF00246.19 CCF36445.1 - 9.2e-18 64.8 0.0 1.3e-17 64.2 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.9 CCF36445.1 - 0.013 14.3 0.0 0.019 13.8 0.0 1.4 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family DUF2817 PF10994.3 CCF36445.1 - 0.032 13.3 0.0 0.043 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) DUF3659 PF12396.3 CCF36447.1 - 1.5e-17 63.0 2.5 1.9e-12 46.6 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3659) AflR PF08493.5 CCF36447.1 - 0.00078 18.5 2.2 0.00078 18.5 1.6 2.8 4 0 0 4 4 4 1 Aflatoxin regulatory protein 2OG-FeII_Oxy_2 PF13532.1 CCF36448.1 - 1.6e-15 57.4 0.0 2.2e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 CCF36448.1 - 7.1e-11 42.2 0.1 1.6e-10 41.1 0.0 1.6 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily W_rich_C PF07483.6 CCF36449.1 - 0.1 12.3 2.0 0.18 11.4 1.4 1.3 1 0 0 1 1 1 0 Tryptophan-rich Synechocystis species C-terminal domain Macro PF01661.16 CCF36450.1 - 7.6e-39 132.2 0.5 1.2e-38 131.6 0.3 1.3 1 0 0 1 1 1 1 Macro domain tRNA-synt_1c PF00749.16 CCF36451.1 - 9.2e-56 188.7 0.2 9.2e-56 188.7 0.1 1.4 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain Hc1 PF07432.8 CCF36451.1 - 0.26 11.4 11.8 0.64 10.2 8.1 1.7 1 0 0 1 1 1 0 Histone H1-like protein Hc1 Rep_fac_C PF08542.6 CCF36452.1 - 2e-15 56.5 0.1 6.2e-15 54.9 0.0 1.9 2 0 0 2 2 1 1 Replication factor C C-terminal domain AAA PF00004.24 CCF36452.1 - 2.6e-15 56.8 0.0 5.2e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 CCF36452.1 - 1.6e-12 47.3 0.0 8.4e-12 45.0 0.0 2.0 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.10 CCF36452.1 - 1.9e-09 36.8 0.0 1.6e-07 30.4 0.0 2.3 3 0 0 3 3 3 1 Rad17 cell cycle checkpoint protein AAA_19 PF13245.1 CCF36452.1 - 2.7e-07 30.2 0.0 5.8e-06 25.9 0.0 2.4 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 CCF36452.1 - 6.7e-07 29.5 0.2 6.6e-06 26.2 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CCF36452.1 - 1.4e-06 28.4 0.2 8.2e-05 22.6 0.0 3.0 1 1 1 3 3 3 1 AAA ATPase domain AAA_30 PF13604.1 CCF36452.1 - 3.7e-06 26.6 0.1 1.5e-05 24.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 CCF36452.1 - 2.4e-05 24.0 0.1 9.7e-05 22.0 0.1 2.2 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 CCF36452.1 - 4e-05 22.7 0.1 0.00023 20.2 0.0 2.1 2 1 1 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 CCF36452.1 - 4.9e-05 23.0 0.1 0.00014 21.6 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DNA_pol3_delta PF06144.8 CCF36452.1 - 4.9e-05 22.9 0.0 9.1e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_14 PF13173.1 CCF36452.1 - 5.6e-05 23.0 0.0 0.00011 22.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.8 CCF36452.1 - 6.3e-05 21.8 0.0 0.18 10.4 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus DUF815 PF05673.8 CCF36452.1 - 8.9e-05 21.5 0.0 0.00015 20.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Sigma54_activat PF00158.21 CCF36452.1 - 0.00016 21.1 0.0 0.00028 20.3 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.6 CCF36452.1 - 0.00035 20.1 0.1 0.0026 17.3 0.1 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 CCF36452.1 - 0.00061 19.0 0.1 0.0031 16.7 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI PhoH PF02562.11 CCF36452.1 - 0.0011 18.2 0.1 0.82 8.8 0.0 2.8 3 0 0 3 3 3 1 PhoH-like protein AAA_24 PF13479.1 CCF36452.1 - 0.003 17.1 0.2 0.0059 16.2 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 CCF36452.1 - 0.0059 16.5 0.0 0.014 15.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 CCF36452.1 - 0.0083 15.8 0.0 0.34 10.5 0.0 2.1 1 1 0 2 2 2 1 Archaeal ATPase AAA_25 PF13481.1 CCF36452.1 - 0.012 15.0 0.0 0.032 13.6 0.0 1.7 2 0 0 2 2 1 0 AAA domain DUF2075 PF09848.4 CCF36452.1 - 0.013 14.4 0.0 0.021 13.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.1 CCF36452.1 - 0.014 15.6 0.0 0.039 14.2 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_17 PF13207.1 CCF36452.1 - 0.02 15.7 0.0 0.055 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 CCF36452.1 - 0.024 14.0 0.0 0.36 10.2 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_10 PF12846.2 CCF36452.1 - 0.032 13.6 0.1 1.8 7.9 0.0 2.3 1 1 1 2 2 2 0 AAA-like domain FtsK_SpoIIIE PF01580.13 CCF36452.1 - 0.036 13.5 0.0 0.27 10.6 0.0 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family DEAD PF00270.24 CCF36452.1 - 0.039 13.4 0.0 0.79 9.1 0.0 2.3 1 1 1 2 2 2 0 DEAD/DEAH box helicase ResIII PF04851.10 CCF36452.1 - 0.061 13.1 0.0 0.14 11.9 0.0 1.7 2 0 0 2 2 1 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.17 CCF36452.1 - 0.083 13.0 0.0 0.19 11.8 0.0 1.7 1 1 0 1 1 1 0 RNA helicase Fringe PF02434.11 CCF36453.1 - 4.5e-06 26.0 2.1 5.3e-05 22.5 1.5 2.3 1 1 0 1 1 1 1 Fringe-like PAN_4 PF14295.1 CCF36453.1 - 0.017 14.8 1.4 0.017 14.8 1.0 2.1 2 0 0 2 2 2 0 PAN domain Galactosyl_T PF01762.16 CCF36453.1 - 0.019 14.5 0.2 0.099 12.2 0.1 2.0 1 1 1 2 2 2 0 Galactosyltransferase PAN_2 PF08276.6 CCF36453.1 - 0.026 14.3 0.4 0.062 13.1 0.3 1.6 1 0 0 1 1 1 0 PAN-like domain Condensation PF00668.15 CCF36454.1 - 1.3e-78 263.9 0.0 1.4e-35 122.5 0.0 4.2 3 1 0 3 3 3 3 Condensation domain AMP-binding PF00501.23 CCF36454.1 - 5.2e-21 74.5 0.0 8.6e-21 73.7 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.20 CCF36454.1 - 1.1e-11 44.8 0.0 2.1e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.1 CCF36454.1 - 0.0014 19.5 0.0 0.0083 17.0 0.0 2.4 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain HxxPF_rpt PF13745.1 CCF36454.1 - 0.018 15.3 0.0 0.043 14.1 0.0 1.7 1 0 0 1 1 1 0 HxxPF-repeated domain Transferase PF02458.10 CCF36454.1 - 0.13 10.6 0.0 0.28 9.5 0.0 1.4 1 0 0 1 1 1 0 Transferase family Wzy_C PF04932.10 CCF36455.1 - 0.011 15.5 0.6 0.011 15.5 0.4 1.1 1 0 0 1 1 1 0 O-Antigen ligase Pex24p PF06398.6 CCF36455.1 - 0.14 10.9 0.6 0.13 11.0 0.4 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin FA_desaturase PF00487.19 CCF36455.1 - 0.27 10.6 6.1 0.37 10.1 3.8 1.5 2 0 0 2 2 2 0 Fatty acid desaturase DUF4131 PF13567.1 CCF36455.1 - 2 7.7 9.7 2.6 7.4 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) VirB3 PF05101.8 CCF36455.1 - 2.1 8.3 6.9 3.7 7.6 4.7 1.4 1 0 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein PrgI PF12666.2 CCF36455.1 - 3.1 8.0 6.6 6 7.0 4.6 1.4 1 0 0 1 1 1 0 PrgI family protein DUF3488 PF11992.3 CCF36455.1 - 6.1 5.3 9.0 7.9 5.0 6.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3488) DUF3043 PF11241.3 CCF36455.1 - 8.6 5.9 7.8 69 2.9 6.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) BCAS2 PF05700.6 CCF36460.1 - 2.8e-44 151.2 2.6 3.2e-44 151.0 1.8 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) TMF_TATA_bd PF12325.3 CCF36460.1 - 0.073 12.8 5.0 0.098 12.3 1.7 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding cNMP_binding PF00027.24 CCF36461.1 - 4.4e-43 145.0 0.0 1.7e-22 79.0 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain GXGXG PF01493.14 CCF36461.1 - 0.069 12.1 0.0 0.16 10.9 0.0 1.6 2 0 0 2 2 2 0 GXGXG motif Sugar_tr PF00083.19 CCF36463.1 - 1.8e-55 188.3 22.1 2.2e-55 188.0 15.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF36463.1 - 7.9e-19 67.5 34.2 7.9e-19 67.5 23.7 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Nuc_H_symport PF03825.11 CCF36463.1 - 0.00026 19.8 3.4 0.00026 19.8 2.4 2.2 2 0 0 2 2 2 1 Nucleoside H+ symporter Sugar_tr PF00083.19 CCF36464.1 - 3.1e-101 339.1 30.2 6.8e-100 334.7 21.0 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF36464.1 - 4.9e-30 104.4 13.1 4.9e-30 104.4 9.1 2.4 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF36464.1 - 8.8e-05 20.8 0.7 8.8e-05 20.8 0.5 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) ELFV_dehydrog PF00208.16 CCF36466.1 - 6.3e-14 52.1 0.0 7.1e-14 51.9 0.0 1.0 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Gemini_AL1 PF00799.15 CCF36466.1 - 0.15 11.9 0.0 8.8 6.2 0.0 2.0 1 1 1 2 2 2 0 Geminivirus Rep catalytic domain Pyr_redox_2 PF07992.9 CCF36467.1 - 0.024 14.5 0.3 0.038 13.8 0.2 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF36467.1 - 0.07 13.1 0.4 0.22 11.5 0.3 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CCF36467.1 - 0.14 10.9 0.5 0.19 10.5 0.4 1.2 1 0 0 1 1 1 0 FAD binding domain Cellulase PF00150.13 CCF36469.1 - 5e-45 153.8 0.2 6.8e-45 153.4 0.2 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.13 CCF36469.1 - 3.4e-12 45.7 10.1 3.4e-12 45.7 7.0 2.5 2 0 0 2 2 2 1 Fungal cellulose binding domain PQ-loop PF04193.9 CCF36470.1 - 3.1e-38 129.1 11.7 5.5e-21 73.8 0.1 3.0 3 0 0 3 3 3 2 PQ loop repeat S1-P1_nuclease PF02265.11 CCF36471.1 - 1.7e-71 240.8 0.1 2e-71 240.6 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease PSI_PSAK PF01241.13 CCF36471.1 - 0.0075 16.2 1.0 0.017 15.0 0.7 1.6 1 0 0 1 1 1 1 Photosystem I psaG / psaK HET PF06985.6 CCF36474.1 - 4.4e-35 120.8 0.4 6.7e-35 120.2 0.3 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Fungal_trans PF04082.13 CCF36475.1 - 1.4e-12 47.0 0.4 2.7e-12 46.1 0.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF36475.1 - 2.3e-06 27.3 11.7 4.4e-06 26.5 8.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tn7_TnsC_Int PF11426.3 CCF36476.1 - 0.011 15.3 0.1 4.6 7.0 0.0 2.1 1 1 1 2 2 2 0 Tn7 transposition regulator TnsC Ail_Lom PF06316.6 CCF36476.1 - 0.091 12.2 0.1 0.11 11.9 0.1 1.1 1 0 0 1 1 1 0 Enterobacterial Ail/Lom protein PSK PF06404.7 CCF36476.1 - 0.37 11.5 7.8 5.6 7.8 0.4 2.6 2 1 1 3 3 3 0 Phytosulfokine precursor protein (PSK) MFS_1 PF07690.11 CCF36478.1 - 1.8e-26 92.7 19.8 2.9e-26 92.0 13.7 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF36478.1 - 3.7e-05 22.3 2.6 3.7e-05 22.3 1.8 2.9 2 1 0 2 2 2 1 MFS/sugar transport protein Sugar_tr PF00083.19 CCF36478.1 - 7.8e-05 21.4 4.0 7.8e-05 21.4 2.8 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 CCF36478.1 - 0.0035 15.6 2.8 0.0056 14.9 1.9 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.2 CCF36478.1 - 0.093 12.5 0.3 0.093 12.5 0.2 2.4 2 0 0 2 2 2 0 MFS_1 like family Ank_4 PF13637.1 CCF36479.1 - 1.4e-13 50.9 0.2 6.9e-11 42.3 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 CCF36479.1 - 2.8e-11 43.6 0.0 4.5e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 CCF36479.1 - 6e-11 41.5 0.9 2.5e-07 30.1 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.1 CCF36479.1 - 7e-09 35.0 0.0 1.6e-05 24.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 CCF36479.1 - 1.4e-08 34.7 0.1 2.8e-07 30.5 0.0 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) FAA_hydrolase PF01557.13 CCF36480.1 - 8.4e-60 201.9 0.0 1.1e-59 201.5 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAD_binding_3 PF01494.14 CCF36481.1 - 2.7e-28 99.0 0.0 3.7e-28 98.6 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF36481.1 - 4.9e-14 51.9 1.6 1.3e-07 30.8 0.2 2.4 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF36481.1 - 6e-08 32.6 0.7 1.8e-07 31.1 0.2 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CCF36481.1 - 6.8e-07 28.4 1.2 1.1e-06 27.7 0.5 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.22 CCF36481.1 - 9.1e-07 29.2 0.0 0.00011 22.4 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF36481.1 - 1.7e-06 27.1 0.3 1.4e-05 24.1 0.2 2.1 1 1 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.9 CCF36481.1 - 2.3e-06 26.3 0.2 0.003 16.1 0.3 2.2 2 0 0 2 2 2 2 HI0933-like protein Trp_halogenase PF04820.9 CCF36481.1 - 5.2e-06 25.3 0.2 3.1e-05 22.7 0.1 2.0 1 1 1 2 2 2 1 Tryptophan halogenase Amino_oxidase PF01593.19 CCF36481.1 - 2.6e-05 23.4 0.5 0.068 12.2 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.9 CCF36481.1 - 3.6e-05 23.7 0.1 0.00013 21.9 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 CCF36481.1 - 0.0001 21.5 0.1 0.00021 20.5 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 CCF36481.1 - 0.00013 21.1 0.9 0.00044 19.4 0.4 1.9 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.1 CCF36481.1 - 0.00055 19.7 0.0 0.0011 18.7 0.0 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 CCF36481.1 - 0.0012 18.9 0.1 0.0039 17.2 0.1 1.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CCF36481.1 - 0.0055 15.6 1.1 0.009 14.9 0.8 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A SE PF08491.5 CCF36481.1 - 0.085 11.6 0.0 0.16 10.7 0.0 1.5 1 1 0 1 1 1 0 Squalene epoxidase NAD_binding_7 PF13241.1 CCF36481.1 - 0.096 12.9 0.0 0.21 11.8 0.0 1.7 1 1 0 1 1 1 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.9 CCF36481.1 - 0.21 10.9 0.3 0.36 10.1 0.2 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PNP_UDP_1 PF01048.15 CCF36482.1 - 4.3e-10 38.9 3.9 5.6e-09 35.3 2.7 2.5 1 1 0 1 1 1 1 Phosphorylase superfamily CRIC_ras_sig PF10534.4 CCF36482.1 - 0.0019 18.1 0.1 0.0053 16.7 0.1 1.7 1 0 0 1 1 1 1 Connector enhancer of kinase suppressor of ras AAA PF00004.24 CCF36483.1 - 5.3e-16 59.0 0.0 9.4e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 CCF36483.1 - 0.0011 18.6 0.1 0.0034 17.0 0.1 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 CCF36483.1 - 0.0014 18.6 0.1 0.0042 17.0 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CCF36483.1 - 0.0021 18.1 0.5 0.031 14.3 0.3 2.6 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 CCF36483.1 - 0.037 13.7 0.0 0.16 11.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.1 CCF36483.1 - 0.071 12.6 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Fungal_trans PF04082.13 CCF36485.1 - 2.4e-19 69.2 0.1 2.7e-19 69.0 0.1 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Scytalone_dh PF02982.9 CCF36486.1 - 2e-95 316.7 1.0 2.4e-95 316.5 0.7 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.1 CCF36486.1 - 1.4e-07 31.4 0.3 2e-07 30.9 0.2 1.2 1 0 0 1 1 1 1 SnoaL-like domain Cyt-b5 PF00173.23 CCF36488.1 - 2.3e-12 46.5 0.0 3.1e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TPR_11 PF13414.1 CCF36489.1 - 5.7e-06 25.8 5.5 0.13 11.9 0.5 4.4 3 1 0 3 3 3 3 TPR repeat TPR_17 PF13431.1 CCF36489.1 - 0.0041 17.2 0.0 10 6.6 0.0 3.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 CCF36489.1 - 0.071 12.9 0.2 42 4.2 0.0 3.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 CCF36489.1 - 0.31 11.7 15.2 3.8 8.4 0.2 5.4 4 1 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.1 CCF36489.1 - 6.3 7.5 17.9 5.6 7.7 0.2 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat ChAPs PF09295.5 CCF36490.1 - 9.2e-11 41.1 0.2 1.1e-10 40.8 0.1 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) Methyltransf_23 PF13489.1 CCF36491.1 - 1.4e-18 67.1 0.0 2.1e-18 66.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF36491.1 - 2.2e-12 46.7 0.0 1.1e-05 25.0 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.7 CCF36491.1 - 1.4e-10 41.5 0.0 2.9e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF36491.1 - 6.2e-10 39.6 0.0 1.7e-08 35.0 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF36491.1 - 2.3e-08 34.3 0.0 3.9e-07 30.4 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF36491.1 - 3.3e-05 23.1 0.0 0.12 11.4 0.0 2.2 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 CCF36491.1 - 5.5e-05 23.4 0.0 0.00022 21.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF36491.1 - 0.00048 19.2 0.0 0.00091 18.3 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.8 CCF36491.1 - 0.0022 17.1 0.0 0.0042 16.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 CCF36491.1 - 0.0058 16.0 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.14 CCF36491.1 - 0.025 14.5 0.0 0.055 13.4 0.0 1.6 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_26 PF13659.1 CCF36491.1 - 0.026 14.5 0.0 0.26 11.3 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain DUF938 PF06080.7 CCF36491.1 - 0.031 13.8 0.0 0.062 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Tannase PF07519.6 CCF36492.1 - 1.7e-81 274.3 0.1 2e-81 274.1 0.0 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.16 CCF36492.1 - 5.5e-05 22.4 0.1 0.061 12.5 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 CCF36492.1 - 0.0003 20.7 0.0 0.00072 19.5 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF36492.1 - 0.0038 16.8 0.1 0.008 15.7 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF36492.1 - 0.0095 15.7 0.0 1.7 8.4 0.0 2.4 2 0 0 2 2 2 2 Alpha/beta hydrolase family ketoacyl-synt PF00109.21 CCF36493.1 - 6.4e-60 202.7 0.0 7.2e-60 202.5 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.18 CCF36493.1 - 0.0022 17.0 0.1 0.003 16.5 0.1 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 CCF36493.1 - 0.091 12.4 0.3 0.15 11.7 0.2 1.3 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Methyltransf_23 PF13489.1 CCF36494.1 - 8.7e-19 67.8 0.0 1.4e-18 67.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF36494.1 - 4.3e-09 36.9 0.0 9.5e-08 32.6 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF36494.1 - 7.4e-09 35.9 0.0 1.4e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF36494.1 - 3.5e-08 33.1 0.0 0.00061 19.4 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.7 CCF36494.1 - 3.5e-07 30.5 0.1 4.3e-06 27.1 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF36494.1 - 0.0022 18.3 0.0 0.0082 16.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF36494.1 - 0.073 13.1 0.1 0.39 10.7 0.0 2.2 2 1 0 2 2 2 0 Methyltransferase domain PrmA PF06325.8 CCF36494.1 - 0.073 12.1 0.0 0.15 11.1 0.0 1.4 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 CCF36494.1 - 0.078 12.3 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain FtsJ PF01728.14 CCF36494.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase ABC_tran PF00005.22 CCF36495.1 - 2.5e-46 157.3 2.7 1.5e-24 86.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 CCF36495.1 - 7.9e-19 68.7 0.0 1.3e-06 28.6 0.0 4.3 4 0 0 4 4 4 4 AAA domain SMC_N PF02463.14 CCF36495.1 - 5.6e-11 42.0 3.1 0.0016 17.7 0.0 4.2 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain ABC2_membrane_3 PF12698.2 CCF36495.1 - 1.4e-10 40.7 20.2 1.4e-10 40.7 14.0 3.3 3 1 0 3 3 3 2 ABC-2 family transporter protein AAA_29 PF13555.1 CCF36495.1 - 3.9e-06 26.3 0.8 0.033 13.6 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.1 CCF36495.1 - 4.8e-06 27.0 1.3 0.018 15.3 0.1 2.3 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 CCF36495.1 - 8.8e-06 24.9 0.1 0.0028 16.8 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 CCF36495.1 - 2.8e-05 24.1 0.1 0.083 12.8 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain IstB_IS21 PF01695.12 CCF36495.1 - 4e-05 23.1 0.2 10 5.4 0.0 4.6 5 0 0 5 5 4 0 IstB-like ATP binding protein SbcCD_C PF13558.1 CCF36495.1 - 0.00044 20.1 0.2 3.4 7.6 0.0 3.7 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.1 CCF36495.1 - 0.00046 20.3 0.7 0.87 9.7 0.0 3.0 3 0 0 3 3 3 1 AAA domain Zeta_toxin PF06414.7 CCF36495.1 - 0.00075 18.6 0.2 1 8.4 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin AAA_15 PF13175.1 CCF36495.1 - 0.0015 17.6 0.0 1.5 7.7 0.0 2.9 3 0 0 3 3 3 1 AAA ATPase domain NB-ARC PF00931.17 CCF36495.1 - 0.0024 16.7 5.8 0.52 9.1 0.3 3.7 3 1 0 3 3 3 1 NB-ARC domain AAA_30 PF13604.1 CCF36495.1 - 0.0035 16.9 0.4 2.6 7.5 0.0 3.0 3 1 1 4 4 4 1 AAA domain AAA_19 PF13245.1 CCF36495.1 - 0.0047 16.6 0.7 1.2 8.8 0.0 3.6 3 0 0 3 3 3 1 Part of AAA domain SRP54 PF00448.17 CCF36495.1 - 0.0055 16.1 1.4 1.3 8.3 0.1 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA PF00004.24 CCF36495.1 - 0.015 15.4 0.9 9.9 6.3 0.3 3.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 CCF36495.1 - 0.026 14.4 0.0 5.7 6.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 CCF36495.1 - 0.028 13.8 0.8 3.5 6.9 0.1 2.3 2 0 0 2 2 2 0 AAA-like domain UPF0079 PF02367.12 CCF36495.1 - 0.028 14.0 0.4 0.66 9.6 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_33 PF13671.1 CCF36495.1 - 0.042 13.7 0.1 5 6.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_13 PF13166.1 CCF36495.1 - 0.068 11.6 0.1 2.5 6.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.1 CCF36495.1 - 0.13 12.2 0.1 5.8 6.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 CCF36495.1 - 0.16 12.1 0.1 7.7 6.7 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_24 PF13479.1 CCF36495.1 - 0.16 11.5 0.1 12 5.3 0.0 2.6 3 0 0 3 3 2 0 AAA domain SRPRB PF09439.5 CCF36495.1 - 0.19 10.9 0.2 1.6 7.8 0.0 2.1 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.4 CCF36495.1 - 0.2 11.1 0.5 3.2 7.2 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Mg_chelatase PF01078.16 CCF36495.1 - 0.2 10.7 0.5 11 5.0 0.1 2.8 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI NACHT PF05729.7 CCF36495.1 - 0.35 10.5 1.9 8.3 6.0 0.0 2.7 2 0 0 2 2 2 0 NACHT domain Arch_ATPase PF01637.13 CCF36495.1 - 0.38 10.4 0.1 32 4.1 0.0 2.5 2 0 0 2 2 2 0 Archaeal ATPase G-alpha PF00503.15 CCF36495.1 - 0.56 8.8 0.1 6.4 5.3 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit DUF1793 PF08760.6 CCF36496.1 - 3.5e-74 248.2 0.8 4.2e-74 248.0 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) RRM_1 PF00076.17 CCF36497.1 - 4.3e-21 74.3 0.0 6e-21 73.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF36497.1 - 6.8e-16 58.0 0.0 9.5e-16 57.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF36497.1 - 2.8e-11 43.0 0.0 3.8e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Reo_sigmaC PF04582.7 CCF36498.1 - 2.2e-05 23.7 25.5 0.01 15.0 4.4 3.9 2 1 1 4 4 4 3 Reovirus sigma C capsid protein GAS PF13851.1 CCF36498.1 - 8.8e-05 21.7 64.7 0.0029 16.8 7.0 4.1 1 1 2 4 4 4 3 Growth-arrest specific micro-tubule binding Spc7 PF08317.6 CCF36498.1 - 0.00071 18.3 10.7 0.00071 18.3 7.4 3.7 1 1 2 3 3 3 1 Spc7 kinetochore protein APG6 PF04111.7 CCF36498.1 - 0.0014 17.7 16.1 0.0014 17.7 11.2 4.4 1 1 2 4 4 4 2 Autophagy protein Apg6 Myosin_tail_1 PF01576.14 CCF36498.1 - 0.0017 16.1 77.2 0.055 11.2 43.4 2.6 1 1 1 2 2 2 2 Myosin tail DUF4140 PF13600.1 CCF36498.1 - 0.0021 18.4 2.7 0.0021 18.4 1.9 8.2 3 2 4 7 7 7 2 N-terminal domain of unknown function (DUF4140) ERM PF00769.14 CCF36498.1 - 0.0025 17.3 13.4 0.0025 17.3 9.3 4.5 1 1 2 4 4 3 2 Ezrin/radixin/moesin family AAA_13 PF13166.1 CCF36498.1 - 0.0027 16.2 12.0 0.0027 16.2 8.4 3.2 1 1 2 3 3 3 1 AAA domain CCDC155 PF14662.1 CCF36498.1 - 0.0029 17.2 18.9 0.0029 17.2 13.1 4.5 1 1 3 4 4 4 1 Coiled-coil region of CCDC155 HALZ PF02183.13 CCF36498.1 - 0.0054 16.4 35.5 0.17 11.6 0.4 7.3 5 2 2 8 8 8 3 Homeobox associated leucine zipper ADIP PF11559.3 CCF36498.1 - 0.0088 15.9 2.2 0.0088 15.9 1.5 6.3 2 2 4 6 6 5 2 Afadin- and alpha -actinin-Binding DUF869 PF05911.6 CCF36498.1 - 0.036 12.3 56.3 0.0038 15.5 15.3 3.6 1 1 3 4 4 4 0 Plant protein of unknown function (DUF869) IncA PF04156.9 CCF36498.1 - 0.036 13.6 71.8 0.27 10.7 5.8 5.2 1 1 2 4 4 4 0 IncA protein bZIP_2 PF07716.10 CCF36498.1 - 0.07 12.9 0.1 0.07 12.9 0.1 10.2 7 2 6 14 14 13 0 Basic region leucine zipper Tropomyosin_1 PF12718.2 CCF36498.1 - 1.4 8.7 82.0 0.4 10.5 2.8 5.4 2 1 4 6 6 5 0 Tropomyosin like CENP-F_leu_zip PF10473.4 CCF36498.1 - 1.8 8.4 77.8 0.27 11.1 12.2 5.9 1 1 4 5 5 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3584 PF12128.3 CCF36498.1 - 7.1 3.8 59.8 1.4 6.1 28.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Sugar_tr PF00083.19 CCF36499.1 - 1.9e-72 244.2 18.7 2.3e-72 244.0 13.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF36499.1 - 1.6e-23 83.0 17.9 1.6e-23 83.0 12.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CCF36499.1 - 0.00066 18.1 1.4 0.00066 18.1 1.0 2.6 2 2 0 2 2 2 2 MFS/sugar transport protein Ldl_recept_b PF00058.12 CCF36500.1 - 3.3e-10 40.1 8.9 0.0053 17.0 0.0 5.5 5 1 0 5 5 5 3 Low-density lipoprotein receptor repeat class B He_PIG PF05345.7 CCF36500.1 - 0.0041 17.1 0.7 0.42 10.6 0.0 2.9 2 0 0 2 2 2 1 Putative Ig domain NHL PF01436.16 CCF36500.1 - 0.083 12.8 0.3 1e+02 3.1 0.0 4.3 5 0 0 5 5 5 0 NHL repeat 3HCDH_N PF02737.13 CCF36501.1 - 9.3e-50 168.7 0.0 1.3e-49 168.3 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.17 CCF36501.1 - 1.9e-15 57.0 0.0 3.7e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain UDPG_MGDP_dh_N PF03721.9 CCF36501.1 - 2.3e-06 27.0 0.0 5.1e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.18 CCF36501.1 - 0.00013 21.6 0.1 0.00032 20.4 0.1 1.6 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.14 CCF36501.1 - 0.00063 18.9 0.0 0.0043 16.2 0.0 2.2 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.11 CCF36501.1 - 0.0012 18.2 0.1 0.0037 16.7 0.1 1.8 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.10 CCF36501.1 - 0.0075 16.1 0.0 0.023 14.5 0.0 1.9 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase TrkA_N PF02254.13 CCF36501.1 - 0.012 15.5 0.0 0.2 11.6 0.0 2.6 2 0 0 2 2 2 0 TrkA-N domain Methyltransf_18 PF12847.2 CCF36501.1 - 0.014 15.9 0.0 0.032 14.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain NAD_binding_10 PF13460.1 CCF36501.1 - 0.024 14.6 0.0 0.29 11.1 0.0 2.4 2 1 0 2 2 2 0 NADH(P)-binding IlvN PF07991.7 CCF36501.1 - 0.034 13.5 0.1 0.23 10.8 0.1 2.1 1 1 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain Pyr_redox PF00070.22 CCF36501.1 - 0.054 13.9 0.6 0.17 12.3 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 CCF36501.1 - 0.058 12.4 0.0 0.082 11.9 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.19 CCF36501.1 - 0.071 11.9 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase F420_oxidored PF03807.12 CCF36501.1 - 0.087 13.2 1.2 0.21 12.0 0.2 2.2 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent TRP PF06011.7 CCF36502.1 - 4.5e-34 117.7 21.5 2.7e-33 115.2 14.9 1.9 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel SecE PF00584.15 CCF36502.1 - 0.033 13.7 0.4 0.033 13.7 0.3 3.1 3 0 0 3 3 3 0 SecE/Sec61-gamma subunits of protein translocation complex DUF106 PF01956.11 CCF36502.1 - 0.3 10.6 7.3 0.38 10.2 0.2 3.2 3 0 0 3 3 3 0 Integral membrane protein DUF106 ATP-synt_C PF00137.16 CCF36504.1 - 2.9e-16 59.1 12.0 3.1e-16 59.0 7.6 1.6 2 0 0 2 2 2 1 ATP synthase subunit C MFS_3 PF05977.8 CCF36504.1 - 0.17 9.9 5.3 0.2 9.7 3.7 1.0 1 0 0 1 1 1 0 Transmembrane secretion effector MOZ_SAS PF01853.13 CCF36505.1 - 1.7e-49 167.6 0.0 2.6e-49 167.0 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family FAD_binding_1 PF00667.15 CCF36506.1 - 2.6e-59 200.3 0.0 5.5e-59 199.2 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 CCF36506.1 - 1.1e-10 42.0 0.0 4.4e-10 40.1 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain POR PF01558.13 CCF36506.1 - 5.7e-09 36.1 0.0 1.4e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase Transketolase_C PF02780.15 CCF36506.1 - 0.00095 19.0 0.1 0.0025 17.7 0.1 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain LLC1 PF14945.1 CCF36506.1 - 0.016 15.4 0.0 0.035 14.4 0.0 1.5 1 0 0 1 1 1 0 Normal lung function maintenance, Low in Lung Cancer 1 protein Fe-ADH PF00465.14 CCF36507.1 - 1.9e-99 332.7 0.0 2.4e-99 332.4 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.1 CCF36507.1 - 4.4e-13 49.1 0.0 1.8e-10 40.5 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.1 CCF36507.1 - 0.0004 19.8 0.1 0.00065 19.1 0.1 1.3 1 0 0 1 1 1 1 Periplasmic binding protein Peptidase_S58 PF03576.9 CCF36508.1 - 2.3e-110 368.8 0.3 2.7e-110 368.6 0.2 1.0 1 0 0 1 1 1 1 Peptidase family S58 tRNA-synt_2 PF00152.15 CCF36509.1 - 3e-87 292.5 0.7 4.2e-87 292.0 0.5 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 CCF36509.1 - 4.4e-10 39.2 0.2 1.2e-09 37.8 0.0 1.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 CCF36509.1 - 5.3e-06 25.8 0.2 0.02 14.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) UCR_Fe-S_N PF10399.4 CCF36509.1 - 0.067 12.3 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal DUF2956 PF11169.3 CCF36509.1 - 0.28 11.1 4.4 0.72 9.8 3.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) COX15-CtaA PF02628.10 CCF36510.1 - 1.5e-96 322.8 6.1 1.9e-96 322.5 4.2 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Utp14 PF04615.8 CCF36511.1 - 1.7e-170 568.7 67.0 1.7e-170 568.7 46.4 3.0 1 1 1 2 2 2 1 Utp14 protein Na_Ca_ex PF01699.19 CCF36512.1 - 2.8e-49 166.3 32.1 5.3e-26 90.8 6.9 2.4 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Glyco_hydro_81 PF03639.8 CCF36513.1 - 1.4e-201 671.2 0.1 1.7e-201 670.9 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 RTA1 PF04479.8 CCF36514.1 - 2.8e-13 49.8 4.2 4.8e-13 49.1 2.9 1.3 1 0 0 1 1 1 1 RTA1 like protein CENP-R PF06729.7 CCF36514.1 - 0.55 9.8 3.2 0.86 9.2 2.2 1.3 1 0 0 1 1 1 0 Kinetochore component, CENP-R Rhomboid PF01694.17 CCF36515.1 - 6.5e-16 58.6 2.0 6.5e-16 58.6 1.4 1.6 2 0 0 2 2 2 1 Rhomboid family Amastin PF07344.6 CCF36516.1 - 0.0077 15.8 1.7 0.011 15.4 1.2 1.3 1 0 0 1 1 1 1 Amastin surface glycoprotein DUF2231 PF09990.4 CCF36516.1 - 0.052 13.8 4.7 0.24 11.7 0.2 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2231) NapB PF03892.9 CCF36516.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Nitrate reductase cytochrome c-type subunit (NapB) DUF1353 PF07087.6 CCF36517.1 - 0.05 13.0 0.0 0.083 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1353) Copper-fist PF00649.13 CCF36518.1 - 0.12 11.6 0.4 0.49 9.6 0.0 2.1 2 0 0 2 2 2 0 Copper fist DNA binding domain AKAP28 PF14469.1 CCF36519.1 - 0.0053 16.3 0.2 0.13 11.8 0.0 2.3 2 0 0 2 2 2 1 28 kDa A-kinase anchor AMP-binding PF00501.23 CCF36521.1 - 9.4e-59 198.8 1.3 1.2e-58 198.4 0.9 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF36521.1 - 2.5e-20 73.2 0.4 5.2e-20 72.1 0.2 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain MerE PF05052.7 CCF36521.1 - 0.084 12.8 0.1 0.24 11.3 0.1 1.8 1 0 0 1 1 1 0 MerE protein Pirin_C PF05726.8 CCF36521.1 - 0.092 12.8 0.0 3.8 7.6 0.0 2.4 1 1 1 2 2 2 0 Pirin C-terminal cupin domain SNF2_N PF00176.18 CCF36522.1 - 2e-47 161.4 0.0 3.2e-47 160.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CCF36522.1 - 2.7e-09 36.7 0.0 8.7e-09 35.1 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_4 PF13871.1 CCF36522.1 - 6e-05 22.6 0.0 0.00014 21.4 0.0 1.5 1 0 0 1 1 1 1 Helicase_C-like zf-C3HC4_3 PF13920.1 CCF36522.1 - 0.0078 15.8 10.7 0.014 15.0 7.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF36522.1 - 0.051 13.4 8.8 0.12 12.2 6.1 1.6 1 0 0 1 1 1 0 Ring finger domain TATR PF03430.8 CCF36522.1 - 0.073 11.6 3.0 0.12 11.0 2.1 1.2 1 0 0 1 1 1 0 Trans-activating transcriptional regulator zf-C3HC4_2 PF13923.1 CCF36522.1 - 0.14 12.2 10.7 0.3 11.1 7.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CCF36522.1 - 0.16 11.8 9.1 0.52 10.2 6.3 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 CCF36522.1 - 2.1 8.1 9.9 4.8 6.9 6.9 1.6 1 0 0 1 1 1 0 zinc-RING finger domain IBR PF01485.16 CCF36523.1 - 2.6e-11 43.2 36.4 7.7e-06 25.6 8.7 2.4 2 0 0 2 2 2 2 IBR domain Methyltransf_16 PF10294.4 CCF36524.1 - 3e-18 65.8 0.0 6.9e-18 64.6 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.9 CCF36524.1 - 0.002 17.5 0.0 0.005 16.2 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase small domain Methyltransf_23 PF13489.1 CCF36524.1 - 0.0033 17.1 0.0 0.0052 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF36524.1 - 0.014 15.9 0.1 0.029 14.9 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain PrmA PF06325.8 CCF36524.1 - 0.017 14.2 0.0 0.034 13.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 CCF36524.1 - 0.057 13.4 0.0 0.26 11.3 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain SET PF00856.23 CCF36529.1 - 8.8e-10 39.1 0.0 1.6e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 SET domain FtsJ PF01728.14 CCF36530.1 - 2.7e-59 200.1 0.0 3.5e-59 199.8 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase NSP13 PF06460.7 CCF36530.1 - 0.085 11.7 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 Coronavirus NSP13 Acetyltransf_1 PF00583.19 CCF36531.1 - 4.6e-07 29.7 0.0 6.6e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF36531.1 - 0.00057 19.9 0.0 0.0009 19.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CCF36531.1 - 0.013 15.5 0.0 0.023 14.7 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF36531.1 - 0.02 14.6 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein SnoaL_2 PF12680.2 CCF36532.1 - 0.0072 16.7 0.1 0.011 16.1 0.1 1.3 1 0 0 1 1 1 1 SnoaL-like domain DUF816 PF05674.7 CCF36532.1 - 0.051 13.3 0.2 0.27 10.9 0.2 1.9 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF816) DUF2576 PF10845.3 CCF36532.1 - 0.34 10.1 0.1 0.34 10.1 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2576) BAR PF03114.13 CCF36533.1 - 1.5e-66 224.2 8.8 1.9e-66 223.9 6.1 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.23 CCF36533.1 - 2.1e-15 55.8 0.0 4.2e-15 54.8 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 CCF36533.1 - 6.7e-14 51.2 0.1 1.2e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 CCF36533.1 - 1.2e-10 40.7 0.4 3.8e-10 39.0 0.0 2.1 3 0 0 3 3 3 1 Variant SH3 domain Sec20 PF03908.8 CCF36533.1 - 0.04 13.6 0.8 3.6 7.3 0.1 2.4 2 0 0 2 2 2 0 Sec20 Vps5 PF09325.5 CCF36533.1 - 0.11 11.7 8.0 0.98 8.6 2.6 2.2 2 0 0 2 2 2 0 Vps5 C terminal like APG6 PF04111.7 CCF36533.1 - 1.5 7.7 10.9 4.2 6.3 5.0 2.1 2 0 0 2 2 2 0 Autophagy protein Apg6 Ectoine_synth PF06339.7 CCF36534.1 - 0.14 12.0 0.0 0.16 11.8 0.0 1.1 1 0 0 1 1 1 0 Ectoine synthase MOSC PF03473.12 CCF36535.1 - 4.8e-17 61.6 0.0 1.3e-16 60.2 0.0 1.7 1 0 0 1 1 1 1 MOSC domain Fer2 PF00111.22 CCF36535.1 - 1.8e-10 40.3 1.6 4.1e-10 39.2 1.1 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NAD_binding_1 PF00175.16 CCF36535.1 - 4e-08 33.7 0.2 2.7e-06 27.9 0.0 2.4 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 CCF36535.1 - 1.5e-05 24.9 0.0 3.2e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain 3-alpha PF03475.9 CCF36535.1 - 0.0043 16.7 0.1 0.0074 15.9 0.0 1.4 1 0 0 1 1 1 1 3-alpha domain RRP7 PF12923.2 CCF36536.1 - 6.1e-33 113.6 13.5 6.1e-33 113.6 9.4 2.3 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) VD10_N PF08476.5 CCF36536.1 - 0.1 12.1 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Viral D10 N-terminal Usp PF00582.21 CCF36536.1 - 0.17 12.0 0.2 0.17 12.0 0.1 2.5 2 1 1 3 3 3 0 Universal stress protein family PC_rep PF01851.17 CCF36538.1 - 0.00018 21.5 6.8 0.026 14.7 0.1 5.0 5 0 0 5 5 5 2 Proteasome/cyclosome repeat eIF3_N PF09440.5 CCF36539.1 - 1.3e-43 148.3 1.8 1.8e-43 147.9 0.4 1.9 2 0 0 2 2 2 1 eIF3 subunit 6 N terminal domain PCI PF01399.22 CCF36539.1 - 2.4e-13 50.3 0.0 6.4e-13 48.9 0.0 1.8 1 0 0 1 1 1 1 PCI domain RPN7 PF10602.4 CCF36539.1 - 0.033 13.5 0.0 0.087 12.2 0.0 1.7 1 0 0 1 1 1 0 26S proteasome subunit RPN7 DUF4318 PF14201.1 CCF36539.1 - 0.1 12.4 0.0 0.28 11.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4318) TPR_14 PF13428.1 CCF36539.1 - 0.12 13.0 1.8 16 6.4 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat WSC PF01822.14 CCF36540.1 - 2.8e-26 91.2 22.7 1e-19 70.1 9.2 2.1 2 0 0 2 2 2 2 WSC domain Toxin_16 PF07945.6 CCF36542.1 - 0.51 10.0 5.3 0.13 11.9 1.4 1.7 2 0 0 2 2 2 0 Janus-atracotoxin DUF2183 PF09949.4 CCF36543.1 - 1.8e-19 69.5 0.1 2.8e-19 68.8 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) Aminotran_1_2 PF00155.16 CCF36544.1 - 1.5e-69 234.6 0.0 1.8e-69 234.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 CCF36544.1 - 2.8e-05 23.4 0.0 4.1e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 CCF36544.1 - 5.7e-05 22.3 0.0 0.00011 21.4 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 CCF36544.1 - 0.00053 18.3 0.0 0.00091 17.6 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 CCF36544.1 - 0.026 13.2 0.0 0.064 11.9 0.0 1.7 1 1 0 1 1 1 0 Aminotransferase class-V Myb_DNA-bind_3 PF12776.2 CCF36545.1 - 3.8e-20 72.3 0.3 8.7e-20 71.1 0.2 1.6 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain PAT1 PF09770.4 CCF36545.1 - 0.0053 15.0 29.1 0.006 14.8 20.2 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Spt20 PF12090.3 CCF36545.1 - 0.031 13.6 2.0 0.046 13.0 1.4 1.3 1 0 0 1 1 1 0 Spt20 family Suf PF05843.9 CCF36545.1 - 0.033 13.9 6.5 0.042 13.5 4.5 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) AvrE PF11725.3 CCF36545.1 - 0.53 7.2 6.8 0.61 7.0 4.7 1.1 1 0 0 1 1 1 0 Pathogenicity factor RR_TM4-6 PF06459.7 CCF36545.1 - 0.93 9.3 4.8 1.7 8.4 3.3 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Transport_MerF PF11431.3 CCF36547.1 - 6.7 6.4 8.4 0.43 10.2 0.7 2.2 2 0 0 2 2 2 0 Membrane transport protein MerF zf-C2H2_4 PF13894.1 CCF36548.1 - 0.25 11.7 0.7 0.51 10.8 0.0 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger HET PF06985.6 CCF36549.1 - 5.7e-20 71.8 5.9 2.6e-18 66.5 4.1 2.4 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DEAD PF00270.24 CCF36550.1 - 4.9e-26 91.2 0.0 3.4e-15 55.9 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF36550.1 - 2.7e-22 78.3 0.2 1e-21 76.5 0.1 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF36550.1 - 7.6e-05 22.6 0.0 0.00016 21.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit TRAP_alpha PF03896.11 CCF36550.1 - 0.13 11.2 1.7 0.28 10.1 1.2 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DNA_pol_phi PF04931.8 CCF36550.1 - 0.19 9.4 5.0 0.31 8.7 3.5 1.3 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.5 CCF36550.1 - 0.42 10.8 9.4 0.031 14.5 2.9 1.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Nucleoplasmin PF03066.10 CCF36550.1 - 0.73 9.3 9.9 2.1 7.8 6.9 1.7 1 0 0 1 1 1 0 Nucleoplasmin NOA36 PF06524.7 CCF36550.1 - 2.9 7.0 6.2 6.3 5.9 4.3 1.5 1 0 0 1 1 1 0 NOA36 protein Ank_2 PF12796.2 CCF36551.1 - 2.1e-82 271.5 7.4 4.9e-19 68.4 0.1 7.2 2 1 3 7 7 7 6 Ankyrin repeats (3 copies) Ank PF00023.25 CCF36551.1 - 1.7e-62 204.2 30.6 4.1e-08 32.6 0.0 14.6 14 1 1 15 15 15 11 Ankyrin repeat Ank_4 PF13637.1 CCF36551.1 - 4.9e-60 198.9 15.1 1.1e-10 41.7 0.0 11.2 3 2 9 12 12 12 12 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF36551.1 - 2e-50 163.7 15.3 0.00012 21.9 0.0 13.8 15 0 0 15 15 15 10 Ankyrin repeat Ank_5 PF13857.1 CCF36551.1 - 2.5e-44 148.2 17.8 6.4e-07 29.4 0.1 10.4 6 5 4 10 10 10 9 Ankyrin repeats (many copies) Glyco_hydro_61 PF03443.9 CCF36552.1 - 1e-57 195.4 0.1 1.2e-57 195.2 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DUF1129 PF06570.6 CCF36553.1 - 0.002 17.4 6.0 0.29 10.3 0.6 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1129) DUF202 PF02656.10 CCF36553.1 - 5.2 7.3 15.5 9.4 6.5 0.7 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF202) RP-C_C PF11800.3 CCF36555.1 - 0.026 14.2 0.4 0.031 13.9 0.3 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF2027 PF09640.5 CCF36555.1 - 0.034 13.5 0.0 0.041 13.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2027) Nucleoplasmin PF03066.10 CCF36555.1 - 5.8 6.4 6.5 1 8.8 0.1 2.0 1 1 1 2 2 2 0 Nucleoplasmin Arteri_GP4 PF02497.10 CCF36558.1 - 0.024 14.5 0.6 0.035 14.0 0.4 1.2 1 0 0 1 1 1 0 Arterivirus glycoprotein KTI12 PF08433.5 CCF36558.1 - 0.05 12.8 0.8 0.059 12.5 0.5 1.1 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Phosphoprotein PF00922.12 CCF36558.1 - 0.3 10.2 6.6 0.38 9.9 4.6 1.1 1 0 0 1 1 1 0 Vesiculovirus phosphoprotein Clathrin PF00637.15 CCF36560.1 - 2.4e-20 72.5 7.7 4.7e-20 71.6 2.3 3.0 2 2 0 2 2 2 1 Region in Clathrin and VPS WD40 PF00400.27 CCF36560.1 - 1.3e-07 31.1 1.7 0.00093 18.9 0.1 4.5 4 1 0 4 4 4 2 WD domain, G-beta repeat zf-RING_2 PF13639.1 CCF36560.1 - 9.8e-05 22.1 0.5 0.00019 21.1 0.3 1.5 1 0 0 1 1 1 1 Ring finger domain Daxx PF03344.10 CCF36560.1 - 0.00021 19.9 6.3 0.00047 18.8 4.4 1.5 1 0 0 1 1 1 1 Daxx Family BUD22 PF09073.5 CCF36560.1 - 0.00022 20.4 3.3 0.00022 20.4 2.3 2.3 2 0 0 2 2 2 1 BUD22 Vps39_1 PF10366.4 CCF36560.1 - 0.0026 17.7 1.1 0.0068 16.4 0.3 2.0 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 zf-RING_5 PF14634.1 CCF36560.1 - 0.012 15.3 3.2 0.031 14.0 2.2 1.7 1 1 0 1 1 1 0 zinc-RING finger domain CDC45 PF02724.9 CCF36560.1 - 0.034 12.1 9.0 0.0038 15.3 2.3 1.9 2 0 0 2 2 2 0 CDC45-like protein TPR_7 PF13176.1 CCF36560.1 - 0.069 12.9 0.8 5.1 7.1 0.0 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat NBP1 PF08537.5 CCF36560.1 - 0.12 11.5 1.5 0.21 10.7 1.0 1.3 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 Nop14 PF04147.7 CCF36560.1 - 0.64 7.8 24.1 0.22 9.3 14.3 1.7 2 0 0 2 2 2 0 Nop14-like family VID27 PF08553.5 CCF36560.1 - 2.4 6.2 9.3 3.8 5.5 6.5 1.2 1 0 0 1 1 1 0 VID27 cytoplasmic protein DNA_pol_phi PF04931.8 CCF36560.1 - 9.5 3.8 21.2 17 2.9 14.7 1.3 1 0 0 1 1 1 0 DNA polymerase phi Apc1 PF12859.2 CCF36561.1 - 7.3e-29 100.0 0.2 2.7e-28 98.2 0.2 2.0 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 1 zf-CCHC PF00098.18 CCF36563.1 - 8.4e-44 145.4 59.9 9.9e-09 34.7 0.7 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.1 CCF36563.1 - 7e-11 41.6 42.4 0.0042 16.7 0.7 7.3 1 1 6 7 7 7 6 Zinc knuckle zf-CCHC_6 PF15288.1 CCF36563.1 - 2.9e-09 36.4 48.6 0.0014 18.2 0.8 7.2 4 1 3 7 7 7 6 Zinc knuckle zf-CCHC_2 PF13696.1 CCF36563.1 - 3.4e-08 32.8 34.9 0.034 13.6 0.7 7.0 4 2 3 7 7 7 6 Zinc knuckle zf-CCHC_4 PF14392.1 CCF36563.1 - 2e-07 30.5 49.0 0.13 11.9 0.4 7.3 7 0 0 7 7 7 5 Zinc knuckle zinc_ribbon_5 PF13719.1 CCF36563.1 - 3.5 7.2 34.1 17 5.1 0.2 6.8 5 2 1 6 6 6 0 zinc-ribbon domain Hydrolase_6 PF13344.1 CCF36564.1 - 2.1e-23 82.1 0.0 4.4e-23 81.0 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CCF36564.1 - 3.6e-12 45.8 0.0 2.1e-11 43.3 0.0 2.3 2 0 0 2 2 2 1 HAD-hyrolase-like HAD_2 PF13419.1 CCF36564.1 - 0.00096 19.4 0.0 1.8 8.7 0.0 2.6 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CCF36564.1 - 0.033 14.5 0.0 0.16 12.3 0.0 2.0 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Sec23_trunk PF04811.10 CCF36565.1 - 1.4e-50 171.9 0.0 2.3e-50 171.2 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 CCF36565.1 - 5.1e-27 93.3 0.0 3e-25 87.6 0.0 2.5 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 CCF36565.1 - 3.4e-18 65.9 0.2 7.7e-18 64.8 0.0 1.7 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.17 CCF36565.1 - 4.4e-10 39.0 0.0 9.9e-10 37.9 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat TEX12 PF15219.1 CCF36565.1 - 0.11 12.4 1.2 0.23 11.4 0.5 1.7 2 0 0 2 2 2 0 Testis-expressed 12 Ribosomal_L36 PF00444.13 CCF36566.1 - 5.3e-22 77.5 10.7 7.7e-22 76.9 7.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L36 Ribosomal_L35p PF01632.14 CCF36566.1 - 0.17 11.7 3.1 0.15 11.9 0.8 1.9 2 0 0 2 2 2 0 Ribosomal protein L35 Peptidase_S8 PF00082.17 CCF36568.1 - 2.6e-20 72.7 0.0 4.2e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Subtilase family TPR_4 PF07721.9 CCF36568.1 - 0.2 12.1 1.0 16 6.3 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat PAPS_reduct PF01507.14 CCF36570.1 - 1.8e-43 148.3 0.4 4.6e-43 147.0 0.0 1.7 2 0 0 2 2 2 1 Phosphoadenosine phosphosulfate reductase family TYW3 PF02676.9 CCF36571.1 - 7.6e-61 204.8 0.0 9.9e-61 204.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase TYW3 DUF1690 PF07956.6 CCF36572.1 - 8.9e-13 48.4 0.1 1e-12 48.2 0.1 1.1 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) CHCH PF06747.8 CCF36572.1 - 0.071 13.0 0.0 0.091 12.7 0.0 1.1 1 0 0 1 1 1 0 CHCH domain Carb_anhydrase PF00194.16 CCF36573.1 - 5.6e-19 68.1 0.0 1.3e-18 66.9 0.0 1.5 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Dehydratase_hem PF13816.1 CCF36575.1 - 4.8e-22 78.3 0.0 5.5e-22 78.1 0.0 1.0 1 0 0 1 1 1 1 Haem-containing dehydratase DUF4188 PF13826.1 CCF36575.1 - 0.00089 19.3 0.0 0.001 19.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4188) PNP_UDP_1 PF01048.15 CCF36576.1 - 5.2e-06 25.6 0.2 5.5e-06 25.5 0.1 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Bac_rhamnosid PF05592.6 CCF36580.1 - 1.9e-12 46.1 0.0 8.7e-12 44.0 0.0 1.8 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase DUF608 PF04685.8 CCF36580.1 - 0.00017 20.4 0.0 0.00026 19.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF608 HA2 PF04408.18 CCF36581.1 - 6.3e-19 67.8 1.6 1.1e-18 67.0 0.0 2.2 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 CCF36581.1 - 2.9e-15 56.0 0.0 7.6e-15 54.7 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 CCF36581.1 - 4.1e-15 55.3 0.0 1.4e-14 53.6 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 CCF36581.1 - 4.9e-10 39.1 0.2 1.8e-09 37.3 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase RWD PF05773.17 CCF36581.1 - 5e-07 29.6 0.1 9.8e-07 28.6 0.0 1.5 1 0 0 1 1 1 1 RWD domain AAA_22 PF13401.1 CCF36581.1 - 0.00029 21.0 0.4 0.002 18.2 0.1 2.5 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 CCF36581.1 - 0.00057 19.7 0.1 0.0017 18.2 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DND1_DSRM PF14709.1 CCF36581.1 - 0.0042 17.3 1.1 0.016 15.5 0.8 2.0 1 1 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 AAA_29 PF13555.1 CCF36581.1 - 0.0074 15.7 0.0 0.017 14.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain UBA PF00627.26 CCF36581.1 - 0.011 15.6 0.2 0.093 12.6 0.0 2.7 3 0 0 3 3 3 0 UBA/TS-N domain KaiC PF06745.8 CCF36581.1 - 0.011 14.8 0.3 0.029 13.4 0.0 1.8 2 0 0 2 2 2 0 KaiC T2SE PF00437.15 CCF36581.1 - 0.016 14.0 0.0 0.052 12.4 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_23 PF13476.1 CCF36581.1 - 0.051 13.8 2.3 0.057 13.7 0.1 2.1 2 0 0 2 2 2 0 AAA domain SPATA25 PF15218.1 CCF36581.1 - 0.055 12.9 0.8 0.11 11.9 0.5 1.4 1 0 0 1 1 1 0 Spermatogenesis-associated protein 25 AAA_10 PF12846.2 CCF36581.1 - 0.078 12.3 0.0 3.9 6.8 0.0 2.9 3 0 0 3 3 3 0 AAA-like domain HIT PF01230.18 CCF36582.1 - 1.4e-16 60.8 0.1 2.5e-16 59.9 0.1 1.4 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 CCF36582.1 - 5e-16 58.9 6.0 3.3e-15 56.3 4.2 2.0 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding TRAP_alpha PF03896.11 CCF36584.1 - 2.5e-08 33.2 0.1 5.2e-08 32.2 0.1 1.6 1 1 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Cyclin_N PF00134.18 CCF36585.1 - 2e-42 143.7 0.2 4.4e-42 142.6 0.1 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 CCF36585.1 - 1.5e-33 115.2 0.0 3.4e-33 114.0 0.0 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain FAD_binding_4 PF01565.18 CCF36587.1 - 1e-19 70.4 0.9 1.6e-19 69.7 0.7 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 CCF36587.1 - 5.8e-10 38.9 0.4 1.9e-09 37.2 0.3 1.8 2 0 0 2 2 2 1 Berberine and berberine like Cytokin-bind PF09265.5 CCF36587.1 - 0.017 14.2 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Glyoxalase PF00903.20 CCF36588.1 - 5.3e-13 49.0 0.1 1e-12 48.1 0.0 1.5 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 CCF36588.1 - 1.4e-09 38.4 0.0 2.3e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain Peptidase_C48 PF02902.14 CCF36588.1 - 0.051 13.1 0.0 0.068 12.7 0.0 1.2 1 0 0 1 1 1 0 Ulp1 protease family, C-terminal catalytic domain Integrase_AP2 PF14657.1 CCF36588.1 - 0.099 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 AP2-like DNA-binding integrase domain Fungal_trans PF04082.13 CCF36589.1 - 3.1e-23 81.9 0.0 4.9e-23 81.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF36589.1 - 3.5e-08 33.2 15.2 5.5e-08 32.5 10.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Clusterin PF01093.12 CCF36589.1 - 0.63 8.7 3.1 1 8.1 2.1 1.2 1 0 0 1 1 1 0 Clusterin Daxx PF03344.10 CCF36589.1 - 4.6 5.5 8.5 8.9 4.6 5.9 1.4 1 0 0 1 1 1 0 Daxx Family SARA PF11409.3 CCF36590.1 - 0.088 12.7 1.4 8.3 6.4 0.3 2.5 2 0 0 2 2 2 0 Smad anchor for receptor activation (SARA) Acetyltransf_3 PF13302.1 CCF36591.1 - 1.4e-37 129.0 0.0 1.7e-37 128.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 CCF36591.1 - 0.033 14.0 0.0 3.2 7.6 0.0 2.6 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF36591.1 - 0.086 12.6 0.0 5 6.9 0.0 2.3 2 0 0 2 2 2 0 FR47-like protein Cse1 PF08506.5 CCF36592.1 - 6.8e-80 268.3 1.5 8.3e-80 268.1 1.0 1.1 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.14 CCF36592.1 - 6.7e-13 48.3 0.0 1.8e-12 47.0 0.0 1.8 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.7 CCF36592.1 - 0.041 13.8 1.2 0.12 12.2 0.8 1.8 1 1 0 1 1 1 0 Exportin 1-like protein DUF3384 PF11864.3 CCF36593.1 - 5.2e-90 302.1 0.0 7.1e-90 301.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3384) MFS_1 PF07690.11 CCF36594.1 - 1.9e-31 109.0 26.8 1e-30 106.6 11.6 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF36594.1 - 7.1e-15 54.5 0.0 7.1e-15 54.5 0.0 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_2 PF13347.1 CCF36594.1 - 8e-07 27.7 0.3 8e-07 27.7 0.2 3.4 3 1 1 4 4 4 2 MFS/sugar transport protein MFS_3 PF05977.8 CCF36594.1 - 0.1 10.6 11.8 0.17 9.9 3.8 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector Chlorosome_CsmC PF11098.3 CCF36596.1 - 0.0016 18.1 10.0 0.0016 18.1 7.0 3.2 2 2 1 3 3 3 1 Chlorosome envelope protein C DUF3723 PF12520.3 CCF36596.1 - 8.9 4.6 8.7 12 4.2 6.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3723) Macoilin PF09726.4 CCF36596.1 - 9.3 4.3 32.9 14 3.8 22.8 1.3 1 0 0 1 1 1 0 Transmembrane protein DUF763 PF05559.6 CCF36597.1 - 0.88 8.4 3.8 1.3 7.8 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF763) TFIIF_alpha PF05793.7 CCF36598.1 - 3.9 5.7 42.5 6 5.1 29.4 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) VPS28 PF03997.7 CCF36599.1 - 2e-55 187.3 0.2 2.4e-55 187.0 0.1 1.0 1 0 0 1 1 1 1 VPS28 protein GvpG PF05120.7 CCF36599.1 - 0.026 14.3 3.0 0.22 11.3 0.2 2.2 2 0 0 2 2 2 0 Gas vesicle protein G Plectin PF00681.15 CCF36599.1 - 0.028 13.9 0.0 0.066 12.7 0.0 1.7 1 0 0 1 1 1 0 Plectin repeat DUF2404 PF10296.4 CCF36600.1 - 0.00099 19.1 0.0 0.0079 16.3 0.0 2.1 2 0 0 2 2 2 1 Putative integral membrane protein conserved region (DUF2404) PIP5K PF01504.13 CCF36601.1 - 2.7e-58 197.0 0.0 6.3e-58 195.8 0.0 1.5 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Methyltransf_PK PF05891.7 CCF36602.1 - 5.7e-13 48.6 0.1 6e-13 48.6 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_PK PF05891.7 CCF36603.1 - 1.2e-65 220.9 0.0 1.3e-65 220.7 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_11 PF08241.7 CCF36603.1 - 0.036 14.5 0.0 0.055 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Docking PF08990.6 CCF36603.1 - 0.13 11.5 0.1 0.23 10.7 0.1 1.4 1 0 0 1 1 1 0 Erythronolide synthase docking YbjM PF11045.3 CCF36604.1 - 0.078 12.7 0.9 0.096 12.4 0.7 1.3 1 1 0 1 1 1 0 Putative inner membrane protein of Enterobacteriaceae NIF PF03031.13 CCF36606.1 - 1.3e-51 174.4 0.6 1.8e-51 173.9 0.4 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF3586 PF12131.3 CCF36607.1 - 0.12 12.4 2.2 0.4 10.7 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3586) AMP-binding PF00501.23 CCF36608.1 - 1.5e-78 264.0 0.4 3.2e-57 193.8 0.1 2.3 1 1 1 2 2 2 2 AMP-binding enzyme Condensation PF00668.15 CCF36608.1 - 1.9e-26 92.6 0.1 2e-25 89.2 0.0 2.2 1 1 0 1 1 1 1 Condensation domain PP-binding PF00550.20 CCF36608.1 - 1.3e-11 44.5 0.0 1.9e-10 40.8 0.0 2.6 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.1 CCF36608.1 - 1.1e-08 35.9 0.1 3.1e-07 31.2 0.0 2.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain adh_short PF00106.20 CCF36609.1 - 8.9e-31 107.0 0.6 1.2e-30 106.6 0.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF36609.1 - 3.8e-28 98.8 0.1 5.1e-28 98.4 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF36609.1 - 1.7e-11 44.1 0.1 2.4e-11 43.6 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF36609.1 - 1.5e-05 24.5 0.1 4.3e-05 23.0 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PA PF02225.17 CCF36609.1 - 0.0014 18.2 0.1 0.0043 16.7 0.1 1.8 1 0 0 1 1 1 1 PA domain Polysacc_synt_2 PF02719.10 CCF36609.1 - 0.046 12.6 0.0 0.07 12.0 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein TFIIB PF00382.14 CCF36610.1 - 2.2e-05 24.1 0.0 0.043 13.6 0.0 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Cyclin_N PF00134.18 CCF36610.1 - 0.0019 17.7 0.0 0.082 12.4 0.0 2.5 2 1 0 2 2 2 1 Cyclin, N-terminal domain DUF2737 PF10930.3 CCF36610.1 - 0.061 12.9 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2737) Rossmann-like PF10727.4 CCF36610.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Rossmann-like domain Vps5 PF09325.5 CCF36611.1 - 1.9e-13 50.2 1.7 2.9e-13 49.6 1.2 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.19 CCF36611.1 - 1e-10 41.3 0.0 2.7e-10 40.0 0.0 1.7 1 0 0 1 1 1 1 PX domain Cullin PF00888.17 CCF36612.1 - 1.4e-50 172.4 0.2 4.6e-50 170.7 0.1 1.8 2 1 0 2 2 2 1 Cullin family APC2 PF08672.6 CCF36612.1 - 5e-20 71.5 0.1 1.8e-19 69.7 0.0 2.0 2 0 0 2 2 2 1 Anaphase promoting complex (APC) subunit 2 TPR_11 PF13414.1 CCF36614.1 - 1.6e-14 53.2 16.7 2.1e-06 27.3 0.5 7.1 6 2 1 7 7 7 3 TPR repeat TPR_16 PF13432.1 CCF36614.1 - 9.7e-11 42.0 17.7 0.052 14.2 0.2 8.3 6 2 2 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.1 CCF36614.1 - 1.4e-08 34.9 15.6 0.25 11.6 0.0 7.0 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.23 CCF36614.1 - 1.4e-08 33.9 5.0 0.061 12.9 0.0 7.9 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_17 PF13431.1 CCF36614.1 - 2.9e-08 33.2 0.2 0.019 15.1 0.0 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.1 CCF36614.1 - 3.8e-06 27.0 20.0 0.62 10.8 0.1 9.3 9 2 4 13 13 9 3 Tetratricopeptide repeat TPR_8 PF13181.1 CCF36614.1 - 2.2e-05 23.8 1.0 30 4.7 0.0 6.5 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_2 PF07719.12 CCF36614.1 - 3.7e-05 23.3 17.7 0.81 9.7 0.0 8.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.1 CCF36614.1 - 8.2e-05 22.4 22.6 0.015 15.1 0.5 6.8 5 2 1 7 7 7 3 Tetratricopeptide repeat TPR_20 PF14561.1 CCF36614.1 - 0.00016 21.7 6.1 0.51 10.4 0.0 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat Apc3 PF12895.2 CCF36614.1 - 0.0066 16.5 2.2 0.0066 16.5 1.5 4.5 5 0 0 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 CCF36614.1 - 0.075 12.8 0.1 0.075 12.8 0.0 5.4 5 1 1 6 6 6 0 Tetratricopeptide repeat PBP_sp32 PF07222.7 CCF36615.1 - 0.16 11.1 2.4 0.27 10.3 1.6 1.3 1 1 0 1 1 1 0 Proacrosin binding protein sp32 Abhydrolase_3 PF07859.8 CCF36616.1 - 1.3e-36 126.1 0.0 1.6e-36 125.8 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 CCF36616.1 - 0.3 9.7 3.5 2.9 6.4 2.4 2.0 1 1 0 1 1 1 0 Carboxylesterase family DNA_binding_1 PF01035.15 CCF36617.1 - 8.6e-17 60.6 0.7 1.3e-08 34.4 0.0 2.2 2 0 0 2 2 2 2 6-O-methylguanine DNA methyltransferase, DNA binding domain HMG_box PF00505.14 CCF36618.1 - 5.4e-22 77.8 0.6 9.4e-22 77.0 0.4 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 CCF36618.1 - 5.2e-07 29.9 0.1 1.4e-06 28.5 0.1 1.7 1 0 0 1 1 1 1 HMG-box domain zf-RING_3 PF14369.1 CCF36618.1 - 0.13 12.2 0.2 0.3 11.1 0.1 1.6 1 0 0 1 1 1 0 zinc-finger Coatomer_WDAD PF04053.9 CCF36619.1 - 2e-173 577.2 0.0 7.8e-173 575.3 0.0 1.8 2 1 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.27 CCF36619.1 - 4.4e-48 159.5 6.7 4.1e-10 39.1 0.1 7.8 8 0 0 8 8 8 6 WD domain, G-beta repeat Nup160 PF11715.3 CCF36619.1 - 6e-06 24.6 2.4 0.0045 15.2 0.0 4.2 2 2 2 4 4 4 3 Nucleoporin Nup120/160 BBS2_Mid PF14783.1 CCF36619.1 - 0.00049 19.8 0.0 0.29 10.9 0.0 3.3 2 1 0 2 2 2 2 Ciliary BBSome complex subunit 2, middle region Mannitol_dh_C PF08125.8 CCF36620.1 - 1.7e-13 50.3 0.0 2e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain FRG1 PF06229.7 CCF36621.1 - 8.1e-55 185.2 0.1 1.3e-54 184.5 0.0 1.3 1 0 0 1 1 1 1 FRG1-like family Fascin PF06268.8 CCF36621.1 - 0.0049 16.9 0.0 0.018 15.1 0.0 1.9 2 0 0 2 2 2 1 Fascin domain 2OG-FeII_Oxy PF03171.15 CCF36622.1 - 0.0012 19.0 0.0 0.0046 17.2 0.0 1.9 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Thioredoxin_4 PF13462.1 CCF36623.1 - 4.6e-05 23.4 0.0 0.0001 22.3 0.0 1.6 1 1 0 1 1 1 1 Thioredoxin ADP_PFK_GK PF04587.10 CCF36623.1 - 0.071 11.3 0.0 0.094 10.9 0.0 1.1 1 0 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region DSBA PF01323.15 CCF36623.1 - 0.17 11.4 1.7 5.4 6.5 0.2 2.4 1 1 1 2 2 2 0 DSBA-like thioredoxin domain DUF1658 PF07871.6 CCF36624.1 - 4 7.1 10.1 0.53 9.9 0.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1658) Glyco_hydro_17 PF00332.13 CCF36625.1 - 2.6e-06 26.7 1.4 1.2e-05 24.5 0.2 2.0 1 1 1 2 2 2 1 Glycosyl hydrolases family 17 DUF2580 PF10824.3 CCF36625.1 - 0.0048 17.2 0.3 0.33 11.3 0.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2580) FA_desaturase PF00487.19 CCF36626.1 - 5.5e-16 58.7 22.7 8.7e-16 58.1 15.7 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 CCF36626.1 - 8.2e-12 44.7 0.0 1.6e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Ribosomal_S27e PF01667.12 CCF36626.1 - 0.052 13.0 0.0 0.89 9.1 0.0 2.2 2 0 0 2 2 2 0 Ribosomal protein S27 Tubulin PF00091.20 CCF36627.1 - 5.3e-72 242.1 0.0 7.7e-72 241.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 CCF36627.1 - 2.9e-35 121.0 0.1 6.5e-35 119.9 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 CCF36627.1 - 4.3e-08 33.1 0.0 8.8e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain AAA_17 PF13207.1 CCF36631.1 - 1.5e-07 32.2 0.5 6.6e-06 26.9 0.3 2.5 1 1 0 1 1 1 1 AAA domain PRK PF00485.13 CCF36631.1 - 8.4e-06 25.4 0.0 1.7e-05 24.4 0.0 1.4 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family T2SE PF00437.15 CCF36631.1 - 4.1e-05 22.6 0.0 0.0052 15.7 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_18 PF13238.1 CCF36631.1 - 0.00017 21.8 1.4 0.0017 18.6 0.6 2.3 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CCF36631.1 - 0.002 17.9 0.1 0.02 14.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 CCF36631.1 - 0.0028 16.7 0.1 0.0083 15.2 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin Thymidylate_kin PF02223.12 CCF36631.1 - 0.0052 16.1 0.0 0.16 11.3 0.0 2.1 2 0 0 2 2 2 1 Thymidylate kinase ArgK PF03308.11 CCF36631.1 - 0.0056 15.5 0.0 0.0085 14.8 0.0 1.2 1 0 0 1 1 1 1 ArgK protein NB-ARC PF00931.17 CCF36631.1 - 0.0096 14.8 0.0 0.014 14.2 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.1 CCF36631.1 - 0.013 15.4 0.0 0.032 14.1 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.1 CCF36631.1 - 0.019 15.0 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 CCF36631.1 - 0.029 14.0 0.1 0.045 13.4 0.1 1.3 1 0 0 1 1 1 0 NTPase AAA_19 PF13245.1 CCF36631.1 - 0.088 12.5 0.4 0.23 11.2 0.3 1.9 1 1 0 1 1 1 0 Part of AAA domain CoaE PF01121.15 CCF36631.1 - 0.091 12.1 0.1 5 6.4 0.0 2.3 2 0 0 2 2 2 0 Dephospho-CoA kinase cobW PF02492.14 CCF36631.1 - 0.11 11.9 0.3 0.16 11.3 0.2 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain RuvB_N PF05496.7 CCF36631.1 - 0.12 11.4 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus SKI PF01202.17 CCF36631.1 - 0.13 12.0 0.1 1.4 8.7 0.0 2.1 2 0 0 2 2 2 0 Shikimate kinase Viral_helicase1 PF01443.13 CCF36631.1 - 0.16 11.4 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Dicer_dimer PF03368.9 CCF36632.1 - 0.12 12.1 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Dicer dimerisation domain PRELI PF04707.9 CCF36633.1 - 5.1e-39 133.3 0.0 6.1e-39 133.0 0.0 1.1 1 0 0 1 1 1 1 PRELI-like family Peptidase_M24 PF00557.19 CCF36634.1 - 5.6e-48 163.2 0.1 7.1e-48 162.9 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 PHD PF00628.24 CCF36635.1 - 5.7e-08 32.3 7.9 9.7e-08 31.5 5.5 1.4 1 0 0 1 1 1 1 PHD-finger ING PF12998.2 CCF36635.1 - 0.013 15.7 0.0 0.037 14.3 0.0 1.9 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding zf-RING-like PF08746.6 CCF36635.1 - 4.8 7.2 6.2 7.5 6.6 4.3 1.3 1 0 0 1 1 1 0 RING-like domain Cys_rich_KTR PF14205.1 CCF36636.1 - 0.03 13.7 0.0 0.039 13.4 0.0 1.3 1 0 0 1 1 1 0 Cysteine-rich KTR XPG_I PF00867.13 CCF36637.1 - 6.5e-14 51.7 0.3 1.4e-13 50.6 0.2 1.6 1 0 0 1 1 1 1 XPG I-region MFS_1 PF07690.11 CCF36638.1 - 3.5e-34 118.0 20.8 3.5e-34 118.0 14.4 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily bZIP_1 PF00170.16 CCF36639.1 - 1.1e-10 41.3 4.0 1.7e-10 40.7 2.8 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 CCF36639.1 - 6.8e-06 25.8 4.1 1.2e-05 24.9 2.9 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 CCF36639.1 - 0.00095 19.4 3.3 0.0025 18.0 2.3 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor OmpH PF03938.9 CCF36639.1 - 0.077 12.9 1.6 0.12 12.2 1.1 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Mnd1 PF03962.10 CCF36639.1 - 0.14 11.7 3.4 0.19 11.3 2.4 1.2 1 0 0 1 1 1 0 Mnd1 family Fungal_trans PF04082.13 CCF36640.1 - 7.7e-17 61.0 0.1 1.4e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain p450 PF00067.17 CCF36641.1 - 2.9e-66 223.9 0.0 6.1e-64 216.2 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 NAD-GH PF10712.4 CCF36642.1 - 5.9e-13 47.9 2.2 7.1e-13 47.6 1.5 1.0 1 0 0 1 1 1 1 NAD-specific glutamate dehydrogenase Autophagy_N PF03986.8 CCF36643.1 - 1.3e-46 157.9 1.0 1.7e-46 157.6 0.0 1.6 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.10 CCF36643.1 - 1e-22 80.0 0.5 2.5e-22 78.8 0.3 1.7 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_Cterm PF10381.4 CCF36643.1 - 1.4e-14 52.8 0.4 2.5e-14 52.0 0.3 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal TRP_N PF14558.1 CCF36645.1 - 1.4e-42 145.0 0.7 1.9e-42 144.6 0.5 1.2 1 0 0 1 1 1 1 ML-like domain TRP PF06011.7 CCF36645.1 - 8e-41 140.0 5.4 1.1e-40 139.6 3.8 1.2 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel E1_DerP2_DerF2 PF02221.10 CCF36645.1 - 0.0011 19.2 0.1 0.0018 18.5 0.0 1.4 1 0 0 1 1 1 1 ML domain Peroxidase_2 PF01328.12 CCF36647.1 - 1.3e-15 56.9 0.1 1.9e-15 56.3 0.1 1.2 1 0 0 1 1 1 1 Peroxidase, family 2 Cyclase PF04199.8 CCF36648.1 - 2.1e-08 34.0 0.0 2.8e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase MFS_1 PF07690.11 CCF36649.1 - 3.9e-38 131.0 55.5 8.3e-35 120.1 20.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Lipocalin_5 PF13924.1 CCF36650.1 - 5.7e-06 26.0 0.0 6.5e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Lipocalin-like domain Prot_inhib_II PF02428.10 CCF36651.1 - 1.8 8.6 8.8 3.1 7.9 0.4 2.1 2 0 0 2 2 2 0 Potato type II proteinase inhibitor family HPP PF04982.8 CCF36653.1 - 0.041 13.7 0.8 0.081 12.7 0.5 1.5 1 0 0 1 1 1 0 HPP family LRR_4 PF12799.2 CCF36654.1 - 4.3e-16 58.1 4.7 4.8e-06 26.0 1.6 4.6 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CCF36654.1 - 6.9e-13 48.1 4.8 9.9e-09 34.8 1.9 2.7 2 0 0 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 CCF36654.1 - 4.2e-09 35.1 7.9 0.28 11.3 0.2 6.2 5 1 1 6 6 6 3 Leucine Rich Repeat LRR_7 PF13504.1 CCF36654.1 - 0.00066 19.4 9.0 26 5.6 0.0 5.6 5 0 0 5 5 5 2 Leucine rich repeat LRR_6 PF13516.1 CCF36654.1 - 0.0035 17.2 8.2 30 5.1 0.1 5.8 6 0 0 6 6 6 0 Leucine Rich repeat Nuc_sug_transp PF04142.10 CCF36655.1 - 4.6e-80 268.2 5.4 6.8e-80 267.6 3.7 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter TPT PF03151.11 CCF36655.1 - 3.2e-10 39.8 24.3 2.3e-05 24.0 7.7 2.3 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.15 CCF36655.1 - 1.9e-07 31.1 22.1 0.00039 20.4 2.6 2.7 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 CCF36655.1 - 3.1e-06 26.3 12.5 1.5e-05 24.1 0.8 2.7 3 0 0 3 3 3 2 UAA transporter family EmrE PF13536.1 CCF36655.1 - 2.1e-05 24.7 17.4 0.00016 21.8 1.3 2.6 2 1 0 2 2 2 2 Multidrug resistance efflux transporter Sec63 PF02889.11 CCF36656.1 - 4.9e-23 81.8 0.0 6.2e-23 81.5 0.0 1.0 1 0 0 1 1 1 1 Sec63 Brl domain HHH_5 PF14520.1 CCF36656.1 - 7.2e-06 26.0 0.0 2.4e-05 24.3 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH PF00633.18 CCF36656.1 - 0.00013 21.4 0.7 0.00042 19.8 0.1 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif DUF4332 PF14229.1 CCF36656.1 - 0.00071 19.5 0.0 0.0022 17.9 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4332) Syntaxin_2 PF14523.1 CCF36657.1 - 0.025 14.5 0.0 0.05 13.6 0.0 1.5 1 1 0 1 1 1 0 Syntaxin-like protein Hce2 PF14856.1 CCF36658.1 - 4.1e-16 58.6 0.2 1.1e-10 41.3 0.0 2.2 2 0 0 2 2 2 2 Pathogen effector; putative necrosis-inducing factor AAA_12 PF13087.1 CCF36659.1 - 1.6e-41 141.8 0.0 2.8e-41 141.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 CCF36659.1 - 1e-30 107.1 0.0 1.8e-30 106.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.1 CCF36659.1 - 1.9e-10 40.6 0.0 4.4e-06 26.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 CCF36659.1 - 1.2e-09 37.7 0.0 6.3e-09 35.4 0.0 2.2 1 0 0 1 1 1 1 Part of AAA domain Helicase_RecD PF05127.9 CCF36659.1 - 0.0015 18.1 0.1 0.19 11.3 0.0 2.5 2 0 0 2 2 2 1 Helicase DUF2075 PF09848.4 CCF36659.1 - 0.0023 16.9 0.4 0.019 13.9 0.0 2.5 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.1 CCF36659.1 - 0.0027 17.7 0.7 0.054 13.4 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain UvrD_C_2 PF13538.1 CCF36659.1 - 0.004 17.2 0.0 0.015 15.4 0.0 2.0 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain ResIII PF04851.10 CCF36659.1 - 0.0068 16.2 0.0 0.017 14.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.13 CCF36659.1 - 0.0081 15.7 0.0 5.5 6.4 0.0 2.9 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.9 CCF36659.1 - 0.0083 15.8 0.1 0.68 9.6 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 CCF36659.1 - 0.058 14.2 0.1 0.31 11.8 0.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.1 CCF36659.1 - 0.084 12.2 0.0 0.21 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.16 CCF36659.1 - 0.12 11.6 0.4 0.95 8.6 0.3 2.2 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain Sugar_tr PF00083.19 CCF36660.1 - 1.3e-40 139.3 3.7 1.5e-40 139.1 2.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF36660.1 - 1e-12 47.5 6.0 1.2e-12 47.1 4.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF36660.1 - 6.5e-05 21.3 1.0 8.1e-05 21.0 0.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Folate_carrier PF01770.13 CCF36660.1 - 0.00041 18.9 2.7 0.00074 18.1 1.9 1.3 1 0 0 1 1 1 1 Reduced folate carrier Glyco_hydro_43 PF04616.9 CCF36661.1 - 6.6e-40 136.9 5.9 8.8e-40 136.5 4.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 DUF676 PF05057.9 CCF36662.1 - 1.9e-05 24.0 0.0 3e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.2 CCF36662.1 - 0.0013 18.6 0.3 0.0041 17.0 0.2 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 CCF36662.1 - 0.0022 17.6 0.0 0.0035 16.9 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein LCAT PF02450.10 CCF36662.1 - 0.015 14.3 0.0 0.02 13.8 0.0 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Abhydrolase_9 PF10081.4 CCF36662.1 - 0.04 12.6 0.0 0.066 11.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta-hydrolase family Tyrosinase PF00264.15 CCF36663.1 - 1.6e-26 93.8 0.3 2.3e-26 93.3 0.2 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase Neur_chan_memb PF02932.11 CCF36664.1 - 0.23 11.3 2.1 0.22 11.3 1.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.17 CCF36664.1 - 1.2 8.0 4.5 1.5 7.7 3.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4551 PF15087.1 CCF36664.1 - 1.7 6.9 6.7 2.1 6.6 4.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CDC45 PF02724.9 CCF36664.1 - 4.7 5.1 7.6 5.7 4.8 5.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Suf PF05843.9 CCF36664.1 - 6.2 6.4 6.9 7.7 6.1 4.8 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) rve PF00665.21 CCF36665.1 - 4.5e-08 33.2 0.0 1e-07 32.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain AA_permease PF00324.16 CCF36666.1 - 2.5e-116 388.8 44.7 3.1e-116 388.5 31.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF36666.1 - 8.4e-33 113.5 45.5 1.2e-32 113.0 31.5 1.1 1 0 0 1 1 1 1 Amino acid permease Fungal_trans PF04082.13 CCF36668.1 - 2.9e-14 52.5 0.6 3.7e-14 52.2 0.4 1.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain AflR PF08493.5 CCF36669.1 - 0.013 14.5 0.0 0.016 14.2 0.0 1.1 1 0 0 1 1 1 0 Aflatoxin regulatory protein CPL PF08144.6 CCF36669.1 - 0.068 13.0 0.0 0.096 12.5 0.0 1.2 1 0 0 1 1 1 0 CPL (NUC119) domain Aldo_ket_red PF00248.16 CCF36670.1 - 6.8e-39 133.3 0.0 8.3e-39 133.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family NAD_binding_6 PF08030.7 CCF36670.1 - 0.071 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Ferric reductase NAD binding domain TAFII28 PF04719.9 CCF36671.1 - 2.7e-22 78.3 0.0 2.6e-20 71.9 0.0 2.2 2 0 0 2 2 2 2 hTAFII28-like protein conserved region TT_ORF2 PF02957.10 CCF36671.1 - 5.5 7.7 7.2 0.92 10.2 1.8 2.1 2 0 0 2 2 2 0 TT viral ORF2 GTP_cyclohydroI PF01227.17 CCF36672.1 - 3.1e-74 248.1 0.4 4.1e-74 247.7 0.3 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.1 CCF36672.1 - 0.00061 19.6 0.0 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 QueF-like protein LAP1C PF05609.7 CCF36672.1 - 0.0032 16.2 5.1 0.0042 15.8 3.5 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) Aa_trans PF01490.13 CCF36673.1 - 2.4e-11 42.7 5.1 3.3e-11 42.3 3.5 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Mo-co_dimer PF03404.11 CCF36674.1 - 1.7e-56 189.4 0.0 3.5e-56 188.4 0.0 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Oxidored_molyb PF00174.14 CCF36674.1 - 4.9e-50 169.2 0.0 7.8e-50 168.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain FAD_binding_6 PF00970.19 CCF36674.1 - 4.4e-30 103.7 0.0 7.9e-30 102.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.23 CCF36674.1 - 2e-23 81.9 0.0 4.5e-23 80.8 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_1 PF00175.16 CCF36674.1 - 1.6e-09 38.3 0.0 3.6e-09 37.1 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 CCF36674.1 - 0.049 13.5 0.0 0.095 12.5 0.0 1.4 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Thioredoxin_4 PF13462.1 CCF36674.1 - 0.16 12.0 0.0 0.34 10.9 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin AIRC PF00731.15 CCF36676.1 - 5.8e-61 204.1 1.3 1.4e-60 202.9 0.9 1.7 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.17 CCF36676.1 - 4.4e-51 172.6 0.0 9.2e-51 171.6 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.1 CCF36676.1 - 1.3e-13 51.0 0.0 3e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 CCF36676.1 - 2e-07 30.5 0.0 4.3e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus XdhC_C PF13478.1 CCF36676.1 - 0.00054 20.2 0.0 0.24 11.7 0.0 2.6 2 0 0 2 2 2 2 XdhC Rossmann domain ATPgrasp_Ter PF15632.1 CCF36676.1 - 0.013 14.2 0.0 0.045 12.4 0.0 1.8 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon PrpR_N PF06506.6 CCF36676.1 - 0.028 13.8 0.2 0.31 10.4 0.0 2.3 2 0 0 2 2 2 0 Propionate catabolism activator CPSase_L_D2 PF02786.12 CCF36677.1 - 3.3e-85 284.6 0.0 6e-85 283.8 0.0 1.4 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 CCF36677.1 - 3.6e-18 65.6 0.0 9.1e-18 64.3 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain ATP-grasp_4 PF13535.1 CCF36677.1 - 8.7e-16 58.1 0.0 1.6e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 CCF36677.1 - 3.4e-14 52.3 0.0 4e-08 32.3 0.0 2.1 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 CCF36677.1 - 7e-10 38.5 0.0 1.1e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 CCF36677.1 - 1.2e-07 31.3 0.0 2.3e-07 30.3 0.0 1.5 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.9 CCF36677.1 - 0.0083 16.0 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.1 CCF36677.1 - 0.024 13.8 0.1 0.064 12.4 0.1 1.7 1 1 0 1 1 1 0 ATP-grasp domain GARS_A PF01071.14 CCF36677.1 - 0.028 13.9 0.3 0.069 12.6 0.0 1.8 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.6 CCF36677.1 - 0.048 13.1 0.0 0.089 12.2 0.0 1.5 1 1 0 1 1 1 0 RimK-like ATP-grasp domain Glyco_hydro_3 PF00933.16 CCF36678.1 - 7.7e-87 291.0 0.0 1.1e-86 290.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 CCF36678.1 - 3.1e-68 229.7 0.0 9.2e-68 228.1 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 CCF36678.1 - 1.3e-22 79.4 0.2 2.7e-22 78.4 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.7 CCF36678.1 - 5.7e-10 39.0 0.1 1.2e-09 37.9 0.1 1.5 1 0 0 1 1 1 1 PA14 domain Lipase_GDSL_2 PF13472.1 CCF36678.1 - 0.032 14.3 0.0 0.083 13.0 0.0 1.7 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Zn_clus PF00172.13 CCF36679.1 - 0.021 14.7 4.7 1.5 8.7 0.1 2.3 1 1 1 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_trans_1_4 PF13692.1 CCF36679.1 - 0.035 14.2 0.0 0.055 13.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferases group 1 OsmC PF02566.14 CCF36680.1 - 9e-18 64.3 0.0 1.4e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 OsmC-like protein RBP_receptor PF14752.1 CCF36681.1 - 0.076 11.3 0.0 0.076 11.3 0.0 1.0 1 0 0 1 1 1 0 Retinol binding protein receptor SecE PF00584.15 CCF36681.1 - 0.14 11.7 0.2 0.18 11.4 0.2 1.1 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex ATG2_CAD PF13329.1 CCF36682.1 - 3.5e-19 68.9 0.1 7.2e-19 67.8 0.1 1.6 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif Chorein_N PF12624.2 CCF36682.1 - 0.0013 18.2 0.1 0.003 17.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter Ald_Xan_dh_C2 PF02738.13 CCF36682.1 - 0.4 8.9 0.0 0.64 8.2 0.0 1.2 1 0 0 1 1 1 0 Molybdopterin-binding domain of aldehyde dehydrogenase OPT PF03169.10 CCF36683.1 - 1.4e-94 317.7 20.7 1.7e-94 317.5 14.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein E1-E2_ATPase PF00122.15 CCF36683.1 - 1.7 7.6 3.8 0.58 9.1 0.6 1.6 2 0 0 2 2 2 0 E1-E2 ATPase Acetyltransf_3 PF13302.1 CCF36684.1 - 7.9e-16 58.5 0.0 1.7e-15 57.4 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CCF36684.1 - 1.7e-06 27.9 0.2 2.7e-06 27.3 0.2 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.1 CCF36684.1 - 0.005 16.7 0.0 0.011 15.6 0.0 1.7 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Fringe PF02434.11 CCF36685.1 - 0.032 13.4 0.0 0.049 12.8 0.0 1.2 1 0 0 1 1 1 0 Fringe-like NmrA PF05368.8 CCF36686.1 - 5.2e-17 61.8 0.0 6.4e-17 61.5 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF36686.1 - 6e-14 52.4 0.0 8.5e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF36686.1 - 7.2e-08 32.1 0.1 1.2e-07 31.4 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.5 CCF36686.1 - 4.2e-06 26.5 0.0 5.4e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 CCF36686.1 - 6.7e-06 26.1 0.1 1e-05 25.5 0.1 1.4 1 1 0 1 1 1 1 short chain dehydrogenase TrkA_N PF02254.13 CCF36686.1 - 3.2e-05 23.8 0.1 4.4e-05 23.4 0.1 1.3 1 1 0 1 1 1 1 TrkA-N domain Saccharop_dh PF03435.13 CCF36686.1 - 0.0022 17.0 0.1 0.0026 16.8 0.1 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase Polysacc_synt_2 PF02719.10 CCF36686.1 - 0.0036 16.2 0.1 0.0051 15.7 0.1 1.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.15 CCF36686.1 - 0.0075 16.3 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.12 CCF36686.1 - 0.031 14.6 0.1 0.06 13.7 0.0 1.6 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Mus7 PF09462.5 CCF36686.1 - 0.045 12.5 0.0 0.05 12.4 0.0 1.0 1 0 0 1 1 1 0 Mus7/MMS22 family DapB_N PF01113.15 CCF36686.1 - 0.088 12.7 0.8 3.4 7.6 0.1 2.1 1 1 1 2 2 2 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.7 CCF36686.1 - 0.15 10.9 0.0 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 Male sterility protein FAD_binding_3 PF01494.14 CCF36687.1 - 1.8e-24 86.4 0.0 3.2e-14 52.7 0.0 2.0 2 0 0 2 2 2 2 FAD binding domain Amino_oxidase PF01593.19 CCF36687.1 - 0.00082 18.5 0.2 0.13 11.2 0.0 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox PF00070.22 CCF36687.1 - 0.021 15.2 0.1 0.021 15.2 0.1 2.2 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF36687.1 - 0.039 12.8 0.2 22 3.8 0.1 2.9 3 0 0 3 3 3 0 Lycopene cyclase protein NAD_binding_8 PF13450.1 CCF36687.1 - 0.044 13.7 0.1 0.1 12.6 0.1 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.2 CCF36687.1 - 0.12 11.3 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF36687.1 - 0.14 12.0 0.1 0.55 10.0 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF36687.1 - 0.25 10.1 1.7 8.7 5.1 0.1 2.2 1 1 1 2 2 2 0 FAD dependent oxidoreductase MFS_1 PF07690.11 CCF36688.1 - 7.7e-12 44.5 55.2 3.4e-08 32.5 21.3 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Pox_A14 PF05767.7 CCF36688.1 - 0.29 11.0 8.7 0.082 12.8 2.3 2.9 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 SnoaL_2 PF12680.2 CCF36689.1 - 2e-09 37.7 0.2 2.7e-09 37.3 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.1 CCF36689.1 - 0.0018 18.4 0.1 0.0027 17.9 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL PF07366.7 CCF36689.1 - 0.069 12.7 0.0 2.2 7.9 0.0 2.2 1 1 1 2 2 2 0 SnoaL-like polyketide cyclase 2-Hacid_dh_C PF02826.14 CCF36690.1 - 5.1e-41 139.7 0.0 2.2e-29 101.8 0.0 2.1 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_10 PF13460.1 CCF36690.1 - 0.018 15.0 0.0 0.036 14.0 0.0 1.4 1 0 0 1 1 1 0 NADH(P)-binding W2 PF02020.13 CCF36691.1 - 3e-18 65.5 2.0 6.6e-18 64.4 1.4 1.6 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.19 CCF36691.1 - 5.5e-08 31.9 6.9 0.00011 21.5 0.9 4.3 1 1 2 4 4 4 3 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.18 CCF36691.1 - 0.0024 17.2 0.0 0.0039 16.5 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep_2 PF14602.1 CCF36691.1 - 0.0031 17.0 6.5 0.37 10.3 0.8 3.7 2 1 1 3 3 3 3 Hexapeptide repeat of succinyl-transferase NTP_transf_3 PF12804.2 CCF36691.1 - 0.012 15.6 0.0 0.029 14.4 0.0 1.6 1 0 0 1 1 1 0 MobA-like NTP transferase domain DUF2410 PF10307.4 CCF36692.1 - 2.8e-80 268.3 0.0 3.7e-80 267.9 0.0 1.2 1 0 0 1 1 1 1 Hypothetical protein (DUF2410) DIOX_N PF14226.1 CCF36693.1 - 3e-25 88.9 0.1 4.6e-25 88.4 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 CCF36693.1 - 3.4e-19 68.9 0.0 7.5e-19 67.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.11 CCF36695.1 - 4.4e-29 101.3 33.7 4.4e-29 101.3 23.3 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF36695.1 - 1.3e-06 27.2 18.2 1.3e-06 27.2 12.6 3.0 2 1 0 2 2 2 1 Sugar (and other) transporter Metallophos PF00149.23 CCF36697.1 - 2.1e-05 23.9 1.3 0.00034 20.0 0.9 2.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CCF36697.1 - 6.9e-05 22.7 0.0 0.00017 21.4 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Sugar_tr PF00083.19 CCF36699.1 - 2.5e-85 286.7 14.5 2.8e-85 286.5 10.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF36699.1 - 6e-30 104.1 22.2 1.5e-25 89.7 1.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CCF36699.1 - 3.9e-09 35.4 16.0 9.3e-05 20.9 2.8 2.6 1 1 1 2 2 2 2 MFS/sugar transport protein BT1 PF03092.11 CCF36699.1 - 0.00021 20.1 0.1 0.00049 18.9 0.1 1.6 1 0 0 1 1 1 1 BT1 family PUCC PF03209.10 CCF36699.1 - 0.0029 16.3 2.5 0.0029 16.3 1.8 3.0 2 1 1 3 3 3 2 PUCC protein Glyco_hydro_28 PF00295.12 CCF36700.1 - 2.4e-45 154.9 4.6 3.8e-45 154.2 3.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 GST_C PF00043.20 CCF36702.1 - 1e-13 51.0 0.0 3.3e-13 49.4 0.0 1.8 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 CCF36702.1 - 8.2e-10 38.7 0.1 2e-09 37.5 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 CCF36702.1 - 1.2e-08 34.6 0.0 2.6e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 CCF36702.1 - 1e-07 32.0 0.0 2.5e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 CCF36702.1 - 4.4e-06 27.1 0.0 7.5e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Ribosomal_S9 PF00380.14 CCF36703.1 - 9.3e-36 122.7 0.1 1.4e-35 122.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S9/S16 KR PF08659.5 CCF36705.1 - 1.3e-57 194.4 0.5 1.3e-57 194.4 0.4 2.0 3 0 0 3 3 3 1 KR domain Acyl_transf_1 PF00698.16 CCF36705.1 - 1.4e-47 162.5 0.0 3.8e-47 161.1 0.0 1.7 1 1 0 1 1 1 1 Acyl transferase domain adh_short PF00106.20 CCF36705.1 - 6.1e-45 153.1 0.7 2.3e-44 151.2 0.5 2.1 1 0 0 1 1 1 1 short chain dehydrogenase PS-DH PF14765.1 CCF36705.1 - 3.8e-44 151.0 3.6 6.2e-27 94.5 0.5 2.5 2 0 0 2 2 2 2 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.17 CCF36705.1 - 1.2e-31 109.0 0.1 3.9e-31 107.3 0.0 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain DUF4643 PF15485.1 CCF36706.1 - 0.063 12.7 2.5 0.066 12.6 1.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4643) 7TMR-DISM_7TM PF07695.6 CCF36707.1 - 0.3 10.7 10.3 0.46 10.1 7.1 1.3 1 1 0 1 1 1 0 7TM diverse intracellular signalling DUF3505 PF12013.3 CCF36708.1 - 4.4e-17 62.2 0.1 1.6e-16 60.4 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3505) 4HBT PF03061.17 CCF36709.1 - 1.2e-08 34.9 0.0 1.7e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily NmrA PF05368.8 CCF36710.1 - 3.4e-18 65.7 0.1 4.3e-18 65.4 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF36710.1 - 6.6e-15 55.5 0.1 1e-14 54.9 0.1 1.3 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF36710.1 - 4.2e-07 29.6 0.0 1.3e-05 24.8 0.1 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF36710.1 - 3.2e-05 22.7 0.0 4.9e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family F420_oxidored PF03807.12 CCF36710.1 - 0.00032 21.0 0.9 0.0009 19.6 0.4 2.0 1 1 1 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.20 CCF36710.1 - 0.00042 20.2 0.3 0.00071 19.5 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF36710.1 - 0.00073 19.2 0.2 0.0013 18.4 0.1 1.4 1 0 0 1 1 1 1 KR domain DapB_N PF01113.15 CCF36710.1 - 0.012 15.5 0.5 0.025 14.4 0.4 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Polysacc_synt_2 PF02719.10 CCF36710.1 - 0.023 13.5 0.1 0.038 12.9 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Glyoxalase_3 PF13468.1 CCF36710.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Glyoxalase-like domain NAD_binding_4 PF07993.7 CCF36710.1 - 0.1 11.4 0.0 0.17 10.7 0.0 1.4 1 0 0 1 1 1 0 Male sterility protein Semialdhyde_dh PF01118.19 CCF36710.1 - 0.12 12.7 0.1 0.21 11.8 0.1 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.12 CCF36710.1 - 0.17 10.7 1.1 0.24 10.2 0.2 1.6 2 0 0 2 2 2 0 RmlD substrate binding domain VMA21 PF09446.5 CCF36711.1 - 9.2e-16 57.5 9.8 1.2e-15 57.1 6.8 1.2 1 0 0 1 1 1 1 VMA21-like domain DUF2406 PF10295.4 CCF36712.1 - 1e-20 73.9 1.0 1e-20 73.9 0.7 2.7 3 0 0 3 3 3 1 Uncharacterised protein (DUF2406) Ribosomal_L35Ae PF01247.13 CCF36714.1 - 1.6e-41 139.9 0.8 1.8e-41 139.8 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.13 CCF36714.1 - 1.2e-05 25.0 0.1 0.0084 16.0 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain Response_reg PF00072.19 CCF36717.1 - 4.8e-21 74.8 0.0 5e-14 52.2 0.0 2.3 2 0 0 2 2 2 2 Response regulator receiver domain Bot1p PF12298.3 CCF36718.1 - 6.4e-49 166.1 2.6 9.8e-49 165.5 1.8 1.3 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein KR PF08659.5 CCF36719.1 - 7e-55 185.4 0.2 1.1e-54 184.8 0.1 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 CCF36719.1 - 5.2e-46 156.6 0.4 1e-45 155.6 0.3 1.5 1 0 0 1 1 1 1 short chain dehydrogenase PP-binding PF00550.20 CCF36719.1 - 0.017 15.3 0.0 0.038 14.2 0.0 1.6 1 0 0 1 1 1 0 Phosphopantetheine attachment site Epimerase PF01370.16 CCF36719.1 - 0.024 14.0 0.0 0.038 13.4 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 CCF36719.1 - 0.035 12.9 0.0 0.057 12.3 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ThiF PF00899.16 CCF36719.1 - 0.097 12.4 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 ThiF family DUF4149 PF13664.1 CCF36720.1 - 2.7e-20 72.2 0.6 3.6e-20 71.8 0.1 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) G-patch PF01585.18 CCF36724.1 - 1.5e-05 24.6 0.3 3.1e-05 23.6 0.2 1.6 1 0 0 1 1 1 1 G-patch domain GRIN_C PF15235.1 CCF36724.1 - 0.0024 17.9 0.2 0.0049 16.9 0.1 1.4 1 0 0 1 1 1 1 G protein-regulated inducer of neurite outgrowth C-terminus DUF2116 PF09889.4 CCF36724.1 - 1.4 8.7 3.4 2.6 7.9 0.6 2.3 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) adh_short PF00106.20 CCF36725.1 - 4.7e-11 42.8 0.0 1.5e-10 41.2 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 CCF36725.1 - 5.5e-06 26.1 0.0 1.2e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF36725.1 - 0.0012 18.3 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family E1-N PF14463.1 CCF36725.1 - 0.019 14.5 0.1 0.031 13.8 0.1 1.3 1 0 0 1 1 1 0 E1 N-terminal domain Synaptobrevin PF00957.16 CCF36726.1 - 1.4e-24 85.4 0.0 1.8e-24 85.1 0.0 1.1 1 0 0 1 1 1 1 Synaptobrevin SpoIIAA-like PF11964.3 CCF36726.1 - 0.05 13.9 0.0 0.058 13.6 0.0 1.1 1 0 0 1 1 1 0 SpoIIAA-like HeLo PF14479.1 CCF36728.1 - 1.3e-26 93.6 2.2 2.6e-26 92.7 1.5 1.5 1 0 0 1 1 1 1 Prion-inhibition and propagation Pkinase PF00069.20 CCF36728.1 - 0.00057 19.1 0.0 0.001 18.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF36728.1 - 0.0015 17.6 0.0 0.0045 16.0 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase HCMVantigenic_N PF12154.3 CCF36730.1 - 0.0044 16.8 2.3 1.4 8.9 0.0 3.3 2 0 0 2 2 2 1 Glycoprotein B N-terminal antigenic domain of HCMV FANCI_S3 PF14677.1 CCF36730.1 - 0.024 14.0 0.6 0.04 13.2 0.4 1.3 1 0 0 1 1 1 0 FANCI solenoid 3 Flavodoxin_5 PF12724.2 CCF36730.1 - 0.13 12.2 0.3 4.8 7.1 0.0 2.3 2 0 0 2 2 2 0 Flavodoxin domain UBA_3 PF09288.5 CCF36730.1 - 0.15 11.6 0.1 0.31 10.6 0.1 1.5 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain DUF1664 PF07889.7 CCF36730.1 - 0.34 10.6 1.3 0.64 9.8 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF342 PF03961.8 CCF36730.1 - 2.6 6.3 7.5 0.14 10.5 1.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF342) GDNF PF02351.11 CCF36731.1 - 0.065 13.7 0.3 5.4 7.6 0.0 2.6 2 1 0 2 2 2 0 GDNF/GAS1 domain Mito_carr PF00153.22 CCF36733.1 - 2.1e-47 158.7 2.7 4.3e-19 68.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Methyltransf_23 PF13489.1 CCF36734.1 - 2.9e-13 49.8 0.0 4e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF36734.1 - 9.1e-12 44.8 0.0 1.1e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF36734.1 - 2.8e-10 40.5 0.1 6.7e-10 39.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF36734.1 - 8.2e-09 35.8 0.0 1.5e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF36734.1 - 1.3e-07 32.1 0.1 2.5e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF36734.1 - 0.00081 19.4 0.5 0.0018 18.3 0.4 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF36734.1 - 0.075 12.1 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Pyr_redox_2 PF07992.9 CCF36735.1 - 3.5e-07 30.2 0.0 4.2e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF36735.1 - 4.3e-05 22.1 0.0 0.0019 16.7 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.1 CCF36735.1 - 6e-05 22.9 0.1 9.7e-05 22.3 0.1 1.4 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 CCF36735.1 - 7.9e-05 21.8 0.3 0.00012 21.2 0.2 1.3 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF36735.1 - 0.0001 21.3 0.2 0.00024 20.1 0.1 1.6 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 CCF36735.1 - 0.00018 21.2 0.8 0.039 13.7 0.1 2.1 1 1 0 2 2 2 2 FAD-NAD(P)-binding FAD_binding_2 PF00890.19 CCF36735.1 - 0.00085 18.2 0.3 0.0014 17.5 0.2 1.4 1 1 1 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.1 CCF36735.1 - 0.0023 18.0 0.1 0.0076 16.3 0.0 1.8 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF36735.1 - 0.0044 16.1 0.0 0.0076 15.3 0.0 1.4 1 0 0 1 1 1 1 Thi4 family K_oxygenase PF13434.1 CCF36735.1 - 0.0058 15.5 0.1 0.44 9.4 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.17 CCF36735.1 - 0.0075 15.1 0.2 0.024 13.5 0.1 1.7 1 1 1 2 2 2 1 Glucose inhibited division protein A Lycopene_cycl PF05834.7 CCF36735.1 - 0.0077 15.1 0.2 0.011 14.6 0.1 1.3 1 1 0 1 1 1 1 Lycopene cyclase protein Trp_halogenase PF04820.9 CCF36735.1 - 0.042 12.4 0.0 0.056 12.0 0.0 1.1 1 0 0 1 1 1 0 Tryptophan halogenase FAD_oxidored PF12831.2 CCF36735.1 - 0.051 12.6 0.3 0.098 11.7 0.0 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase rRNA_processing PF08524.6 CCF36736.1 - 0.0036 17.1 3.7 0.0044 16.8 2.5 1.2 1 0 0 1 1 1 1 rRNA processing 4HBT PF03061.17 CCF36737.1 - 3.1e-09 36.8 0.1 5e-09 36.1 0.1 1.3 1 0 0 1 1 1 1 Thioesterase superfamily SR-25 PF10500.4 CCF36737.1 - 1.6 8.1 9.9 2.1 7.7 6.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MFS_1 PF07690.11 CCF36738.1 - 6.7e-27 94.1 18.6 6.7e-27 94.1 12.9 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF36738.1 - 0.0056 16.4 2.9 0.074 12.8 0.4 2.7 2 0 0 2 2 2 1 MFS_1 like family Pectate_lyase PF03211.8 CCF36739.1 - 4e-65 219.2 6.9 5.3e-65 218.8 4.8 1.0 1 0 0 1 1 1 1 Pectate lyase Pkinase PF00069.20 CCF36740.1 - 1.3e-65 221.1 0.0 1.8e-65 220.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF36740.1 - 2.9e-40 138.0 0.1 4.2e-40 137.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF36740.1 - 2.3e-07 30.0 0.0 3.7e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like POLO_box PF00659.13 CCF36740.1 - 8.8e-06 25.6 0.7 0.0021 18.0 0.0 3.1 3 0 0 3 3 3 1 POLO box duplicated region Kdo PF06293.9 CCF36740.1 - 0.0029 16.6 0.0 0.0055 15.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Rav1p_C PF12234.3 CCF36740.1 - 0.13 10.4 0.2 0.23 9.5 0.2 1.3 1 0 0 1 1 1 0 RAVE protein 1 C terminal OPA3 PF07047.7 CCF36741.1 - 1e-38 132.1 5.8 3.3e-38 130.4 4.0 2.1 1 1 0 1 1 1 1 Optic atrophy 3 protein (OPA3) DUF4303 PF14136.1 CCF36741.1 - 0.05 13.2 0.3 0.098 12.3 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4303) AKNA PF12443.3 CCF36741.1 - 0.19 11.7 6.7 0.59 10.1 0.5 2.6 2 0 0 2 2 2 0 AT-hook-containing transcription factor DUF755 PF05501.6 CCF36741.1 - 0.25 11.4 10.1 0.69 9.9 7.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF2681 PF10883.3 CCF36741.1 - 0.51 10.5 5.6 5.4 7.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) SR-25 PF10500.4 CCF36741.1 - 0.88 9.0 23.5 0.015 14.7 10.4 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CDK5_activator PF03261.10 CCF36741.1 - 2.8 7.1 6.4 4.3 6.5 4.5 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein She9_MDM33 PF05546.6 CCF36743.1 - 8.3e-62 208.4 6.0 1e-61 208.1 4.2 1.1 1 0 0 1 1 1 1 She9 / Mdm33 family Erythro-docking PF09277.6 CCF36743.1 - 0.16 11.7 1.5 2.8 7.7 0.0 2.7 2 0 0 2 2 2 0 Erythronolide synthase, docking Mnd1 PF03962.10 CCF36743.1 - 0.39 10.3 2.9 0.62 9.7 2.0 1.2 1 0 0 1 1 1 0 Mnd1 family Nif11 PF07862.6 CCF36743.1 - 1.5 8.8 3.8 0.55 10.2 0.3 2.1 2 0 0 2 2 2 0 Nitrogen fixation protein of unknown function Tropomyosin_1 PF12718.2 CCF36743.1 - 3.9 7.3 9.6 1.9 8.3 1.9 2.2 1 1 1 2 2 2 0 Tropomyosin like ADIP PF11559.3 CCF36743.1 - 9 6.1 10.7 1.8 8.4 2.2 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Mito_carr PF00153.22 CCF36744.1 - 8.8e-66 217.6 4.8 1e-23 82.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Abhydrolase_3 PF07859.8 CCF36745.1 - 3.6e-41 141.0 0.0 4.7e-41 140.6 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF36745.1 - 3.5e-06 26.8 0.3 4.9e-06 26.3 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF36745.1 - 3.1e-05 23.2 0.0 0.12 11.6 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family COesterase PF00135.23 CCF36745.1 - 0.00025 19.8 0.3 0.00044 19.1 0.0 1.4 2 0 0 2 2 2 1 Carboxylesterase family DLH PF01738.13 CCF36745.1 - 0.022 14.0 0.0 0.036 13.3 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family OPT PF03169.10 CCF36746.1 - 9e-131 437.3 46.4 1e-130 437.1 32.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein HET PF06985.6 CCF36747.1 - 4.6e-30 104.5 0.1 8.2e-30 103.7 0.1 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Thioredoxin PF00085.15 CCF36748.1 - 1.3e-28 98.6 0.0 1.7e-28 98.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 CCF36748.1 - 3.7e-06 27.1 0.1 5e-05 23.4 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.5 CCF36748.1 - 2e-05 24.1 0.0 0.00056 19.4 0.0 2.0 1 1 1 2 2 2 1 Redoxin Thioredoxin_8 PF13905.1 CCF36748.1 - 2.5e-05 24.3 0.0 0.00061 19.8 0.0 2.0 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_9 PF14595.1 CCF36748.1 - 3.3e-05 23.4 0.0 4e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.16 CCF36748.1 - 0.00079 19.1 0.0 0.0013 18.4 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.1 CCF36748.1 - 0.00081 19.3 0.0 0.0016 18.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Glutaredoxin PF00462.19 CCF36748.1 - 0.0013 18.7 0.0 0.0029 17.5 0.0 1.8 1 1 0 1 1 1 1 Glutaredoxin DAO PF01266.19 CCF36749.1 - 9.9e-31 106.9 1.2 1.2e-30 106.6 0.8 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF36749.1 - 0.00018 21.4 0.5 0.00055 19.9 0.1 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CCF36749.1 - 0.0021 16.9 0.0 0.0036 16.2 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 CCF36749.1 - 0.015 14.3 0.1 0.015 14.3 0.1 1.7 2 0 0 2 2 2 0 Thi4 family Pyr_redox PF00070.22 CCF36749.1 - 0.016 15.6 0.1 0.046 14.1 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF36749.1 - 0.13 10.8 0.1 0.28 9.7 0.0 1.5 2 0 0 2 2 2 0 Tryptophan halogenase PTR2 PF00854.16 CCF36750.1 - 9.3e-09 34.5 0.1 1.2e-08 34.1 0.1 1.1 1 0 0 1 1 1 1 POT family ApoL PF05461.6 CCF36750.1 - 1.1 8.4 3.3 1.7 7.7 2.3 1.2 1 0 0 1 1 1 0 Apolipoprotein L DUF3218 PF11508.3 CCF36751.1 - 0.041 13.3 0.2 0.047 13.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3218) Mucin PF01456.12 CCF36752.1 - 1.8 8.3 16.1 4 7.2 11.2 1.5 1 1 0 1 1 1 0 Mucin-like glycoprotein MGC-24 PF05283.6 CCF36752.1 - 4.8 6.9 7.6 7.9 6.2 5.3 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) GATase PF00117.23 CCF36754.1 - 0.0011 18.4 0.0 0.0015 18.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Bd3614_N PF14442.1 CCF36754.1 - 0.008 16.1 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Bd3614-like deaminase N-terminal ADH_N PF08240.7 CCF36755.1 - 1.4e-20 73.0 4.4 5.8e-20 71.0 0.2 3.0 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF36755.1 - 8.2e-18 64.2 1.2 1.8e-17 63.1 0.9 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase CoA_binding PF02629.14 CCF36755.1 - 0.0021 18.5 0.3 0.0052 17.2 0.2 1.7 1 0 0 1 1 1 1 CoA binding domain AlaDh_PNT_C PF01262.16 CCF36755.1 - 0.0084 15.6 0.6 0.018 14.5 0.5 1.5 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.14 CCF36755.1 - 0.012 14.7 0.3 0.022 13.8 0.2 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Clr5 PF14420.1 CCF36756.1 - 1.5e-20 72.8 0.5 2.7e-20 71.9 0.3 1.5 1 0 0 1 1 1 1 Clr5 domain RNA_capsid PF03035.9 CCF36757.1 - 0.076 12.8 0.8 0.079 12.7 0.6 1.1 1 0 0 1 1 1 0 Calicivirus putative RNA polymerase/capsid protein Asp_protease PF09668.5 CCF36758.1 - 1.5e-60 202.2 0.4 2.2e-60 201.6 0.3 1.3 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.1 CCF36758.1 - 2.1e-12 47.3 0.1 5e-12 46.1 0.0 1.7 2 0 0 2 2 2 1 Aspartyl protease UBA PF00627.26 CCF36758.1 - 8e-09 35.0 0.0 2.3e-08 33.6 0.0 1.9 1 0 0 1 1 1 1 UBA/TS-N domain gag-asp_proteas PF13975.1 CCF36758.1 - 6.6e-08 32.2 0.1 1.7e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease ubiquitin PF00240.18 CCF36758.1 - 1.1e-07 31.1 0.0 2.5e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family RVP_2 PF08284.6 CCF36758.1 - 8.8e-07 28.9 0.0 1.4e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.15 CCF36758.1 - 8.6e-06 25.5 0.0 2.3e-05 24.2 0.0 1.7 1 1 0 1 1 1 1 Retroviral aspartyl protease Rad60-SLD PF11976.3 CCF36758.1 - 0.029 14.0 0.0 0.068 12.8 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Methyltransf_8 PF05148.10 CCF36759.1 - 8.7e-36 123.5 0.5 2.9e-34 118.6 0.0 2.7 2 1 1 3 3 3 1 Hypothetical methyltransferase Methyltransf_11 PF08241.7 CCF36759.1 - 2.4e-07 31.1 0.0 7.2e-07 29.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF36759.1 - 0.00098 18.7 0.1 0.14 11.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF36759.1 - 0.02 14.2 0.1 1.7 7.9 0.0 2.3 1 1 1 2 2 2 0 Methyltransferase small domain Methyltransf_32 PF13679.1 CCF36759.1 - 0.029 14.0 0.0 0.055 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.1 CCF36759.1 - 0.1 12.9 0.2 4.9 7.5 0.1 2.5 1 1 0 1 1 1 0 Methyltransferase domain G-gamma PF00631.17 CCF36761.1 - 2.5e-27 94.4 0.0 3.2e-27 94.0 0.0 1.1 1 0 0 1 1 1 1 GGL domain Tox-HDC PF15656.1 CCF36761.1 - 0.11 12.7 0.0 0.13 12.4 0.0 1.1 1 0 0 1 1 1 0 Toxin with a H, D/N and C signature zf-RING_2 PF13639.1 CCF36762.1 - 3.8e-06 26.6 13.2 6.2e-06 25.9 9.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 CCF36762.1 - 3e-05 23.5 10.4 4.8e-05 22.9 7.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF36762.1 - 0.00011 21.8 9.0 0.00016 21.3 6.3 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 CCF36762.1 - 0.0011 19.0 10.7 0.0026 17.8 7.5 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 CCF36762.1 - 0.0013 18.6 9.5 0.0021 18.0 6.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CCF36762.1 - 0.89 9.4 5.7 2 8.2 4.0 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Drc1-Sld2 PF11719.3 CCF36763.1 - 6.1e-96 322.1 24.0 6.9e-96 321.9 16.7 1.0 1 0 0 1 1 1 1 DNA replication and checkpoint protein FMO-like PF00743.14 CCF36764.1 - 0.034 12.3 0.0 0.049 11.8 0.0 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Fungal_trans PF04082.13 CCF36765.1 - 2.4e-12 46.3 0.0 4.5e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF36765.1 - 1.3e-07 31.3 14.9 2.2e-07 30.6 10.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF503 PF04456.7 CCF36765.1 - 0.14 11.7 0.2 0.31 10.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF503) CH PF00307.26 CCF36766.1 - 1.2e-59 198.9 0.0 3.7e-16 59.1 0.0 4.1 4 0 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.3 CCF36766.1 - 0.0053 16.3 0.0 18 5.0 0.0 3.5 3 0 0 3 3 3 2 CAMSAP CH domain MBOAT PF03062.14 CCF36767.1 - 9.3e-39 133.4 20.4 9.3e-39 133.4 14.1 2.2 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.1 CCF36767.1 - 2e-06 27.7 5.7 4.9e-06 26.5 3.9 1.6 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Peptidase_M20 PF01546.23 CCF36768.1 - 1.9e-28 99.2 0.0 2.6e-28 98.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 CCF36768.1 - 1.3e-09 37.8 0.0 2.5e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain WG_beta_rep PF14903.1 CCF36768.1 - 0.0032 17.6 0.1 0.0073 16.5 0.0 1.5 1 0 0 1 1 1 1 WG containing repeat Peptidase_M42 PF05343.9 CCF36768.1 - 0.033 12.9 0.0 0.27 9.9 0.0 2.2 3 0 0 3 3 3 0 M42 glutamyl aminopeptidase CBM_1 PF00734.13 CCF36769.1 - 3.6e-09 36.1 5.1 1.1e-08 34.5 3.6 1.9 1 0 0 1 1 1 1 Fungal cellulose binding domain BNR PF02012.15 CCF36769.1 - 0.00014 21.1 32.7 0.42 10.6 0.1 8.8 8 0 0 8 8 8 4 BNR/Asp-box repeat Kelch_3 PF13415.1 CCF36769.1 - 0.002 18.2 0.2 0.002 18.2 0.1 4.6 5 0 0 5 5 5 1 Galactose oxidase, central domain Toxin_7 PF05980.7 CCF36769.1 - 0.35 10.9 1.3 0.63 10.1 0.9 1.4 1 0 0 1 1 1 0 Toxin 7 Corona_nucleoca PF00937.13 CCF36769.1 - 2.2 7.1 7.4 0.15 10.9 1.2 1.8 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein Ank PF00023.25 CCF36770.1 - 7.1e-71 230.7 7.5 2.4e-11 42.8 0.0 9.5 9 0 0 9 9 9 8 Ankyrin repeat Ank_2 PF12796.2 CCF36770.1 - 5.1e-70 231.8 1.2 4.1e-20 71.9 0.0 5.3 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF36770.1 - 3.4e-64 212.1 8.1 5.9e-12 45.7 0.1 6.4 2 2 5 7 7 7 7 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF36770.1 - 1.9e-51 170.8 8.5 1.6e-09 37.6 0.0 9.5 1 1 8 9 9 9 9 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF36770.1 - 3.5e-48 156.7 0.6 3.8e-08 32.8 0.0 10.0 10 0 0 10 10 10 8 Ankyrin repeat EthD PF07110.6 CCF36772.1 - 0.00036 21.4 0.0 0.0014 19.5 0.0 1.8 1 1 0 1 1 1 1 EthD domain DJ-1_PfpI PF01965.19 CCF36773.1 - 1.1e-20 73.5 0.0 1.5e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family DJ-1_PfpI_N PF13587.1 CCF36773.1 - 3.7e-10 39.1 0.0 7.2e-10 38.2 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of DJ-1_PfpI family Epimerase PF01370.16 CCF36774.1 - 9.4e-18 64.5 0.0 2.2e-17 63.2 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 CCF36774.1 - 2.5e-12 46.2 0.0 5.9e-11 41.7 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 CCF36774.1 - 5.3e-12 45.0 0.0 8.4e-12 44.3 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 CCF36774.1 - 3.5e-08 33.6 0.2 8e-08 32.5 0.1 1.8 1 1 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 CCF36774.1 - 4.2e-06 25.8 0.0 5.6e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 CCF36774.1 - 2e-05 24.5 0.6 5.3e-05 23.1 0.4 1.7 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.8 CCF36774.1 - 2.4e-05 23.6 0.0 8.2e-05 21.9 0.0 1.9 2 0 0 2 2 2 1 NmrA-like family KR PF08659.5 CCF36774.1 - 4.9e-05 23.0 0.1 8.7e-05 22.2 0.1 1.4 1 0 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.12 CCF36774.1 - 0.033 13.0 0.2 0.066 12.0 0.1 1.5 2 0 0 2 2 2 0 RmlD substrate binding domain NAD_binding_10 PF13460.1 CCF36775.1 - 7.4e-14 52.1 0.2 1.1e-13 51.6 0.2 1.3 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF36775.1 - 3.5e-13 49.3 0.0 4.9e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Saccharop_dh PF03435.13 CCF36775.1 - 5.2e-11 42.1 0.2 6.6e-11 41.8 0.2 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase F420_oxidored PF03807.12 CCF36775.1 - 2.4e-06 27.8 0.1 4.8e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.17 CCF36775.1 - 1.4e-05 25.5 0.1 2.4e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.19 CCF36775.1 - 9.3e-05 22.7 0.1 0.00016 21.9 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain adh_short PF00106.20 CCF36775.1 - 0.00048 20.0 2.2 0.0039 17.1 1.5 2.5 1 1 0 1 1 1 1 short chain dehydrogenase DapB_N PF01113.15 CCF36775.1 - 0.00054 19.8 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.16 CCF36775.1 - 0.00072 19.0 0.1 0.0011 18.4 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.13 CCF36775.1 - 0.0065 16.4 0.0 0.017 15.1 0.0 1.8 2 0 0 2 2 2 1 TrkA-N domain KR PF08659.5 CCF36775.1 - 0.01 15.5 1.1 0.029 14.0 0.8 1.9 1 1 0 1 1 1 0 KR domain 3Beta_HSD PF01073.14 CCF36775.1 - 0.011 14.4 0.0 0.017 13.8 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Ldh_1_N PF00056.18 CCF36775.1 - 0.017 14.9 0.3 0.058 13.2 0.2 1.9 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 CCF36775.1 - 0.026 14.6 0.0 0.043 13.9 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_Gly3P_dh_N PF01210.18 CCF36775.1 - 0.027 14.2 0.6 0.17 11.6 0.5 2.2 2 1 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_4 PF07993.7 CCF36775.1 - 0.044 12.7 0.0 0.096 11.5 0.0 1.6 1 0 0 1 1 1 0 Male sterility protein THF_DHG_CYH_C PF02882.14 CCF36775.1 - 0.095 11.7 0.0 0.25 10.4 0.0 1.6 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain LMF1 PF06762.9 CCF36776.1 - 1 8.0 5.1 1.6 7.4 3.4 1.4 1 1 0 1 1 1 0 Lipase maturation factor DAO PF01266.19 CCF36777.1 - 2.6e-63 214.0 1.1 3.9e-63 213.5 0.7 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GCV_T PF01571.16 CCF36777.1 - 2.8e-48 164.1 0.0 4.7e-48 163.3 0.0 1.4 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 CCF36777.1 - 4.7e-16 58.6 0.1 1.2e-15 57.2 0.1 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Pyr_redox PF00070.22 CCF36777.1 - 0.00019 21.7 0.6 0.046 14.1 0.1 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF36777.1 - 0.00021 21.4 0.0 0.00058 19.9 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.16 CCF36777.1 - 0.00094 19.0 0.1 0.002 17.9 0.0 1.5 1 0 0 1 1 1 1 ThiF family FAD_binding_2 PF00890.19 CCF36777.1 - 0.0022 16.9 0.6 0.0097 14.7 0.4 2.0 2 1 0 2 2 2 1 FAD binding domain Trp_halogenase PF04820.9 CCF36777.1 - 0.0027 16.4 1.5 0.026 13.1 0.0 2.1 2 0 0 2 2 2 1 Tryptophan halogenase TrkA_N PF02254.13 CCF36777.1 - 0.0032 17.4 0.2 0.01 15.8 0.0 1.9 2 0 0 2 2 2 1 TrkA-N domain NAD_binding_9 PF13454.1 CCF36777.1 - 0.014 15.2 0.5 0.13 12.0 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Shikimate_DH PF01488.15 CCF36777.1 - 0.025 14.6 0.0 0.054 13.6 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_8 PF13450.1 CCF36777.1 - 0.047 13.7 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 CCF36777.1 - 0.074 11.9 0.2 0.9 8.3 0.1 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein 3Beta_HSD PF01073.14 CCF36778.1 - 0.055 12.1 0.0 0.076 11.6 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family HET PF06985.6 CCF36781.1 - 8.7e-14 51.8 0.0 1.9e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) UPF0029 PF01205.14 CCF36782.1 - 2.8e-30 104.2 0.0 4.4e-30 103.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.17 CCF36782.1 - 9.2e-07 28.7 0.0 2.9e-06 27.1 0.0 1.8 1 1 0 1 1 1 1 RWD domain Use1 PF09753.4 CCF36784.1 - 2.5e-10 40.2 0.0 2.5e-10 40.2 0.0 1.9 2 0 0 2 2 2 1 Membrane fusion protein Use1 GldM_N PF12081.3 CCF36784.1 - 0.002 17.7 1.2 0.0039 16.7 0.8 1.4 1 0 0 1 1 1 1 GldM N-terminal domain Synaptobrevin PF00957.16 CCF36784.1 - 0.21 11.2 1.6 1.8 8.2 0.0 2.5 2 0 0 2 2 2 0 Synaptobrevin Cytochrom_B562 PF07361.6 CCF36784.1 - 0.27 11.6 3.8 0.51 10.7 0.9 2.3 2 0 0 2 2 2 0 Cytochrome b562 DUF2959 PF11172.3 CCF36784.1 - 0.99 9.1 6.8 1.4 8.6 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2959) Phage_Gp23 PF10669.4 CCF36784.1 - 6.9 6.8 9.6 0.64 10.1 1.0 2.8 2 2 1 3 3 3 0 Protein gp23 (Bacteriophage A118) NAD_binding_10 PF13460.1 CCF36785.1 - 2.2e-15 57.1 0.0 3.8e-15 56.3 0.0 1.4 1 1 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF36785.1 - 0.042 13.1 0.0 0.06 12.5 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family Epimerase PF01370.16 CCF36785.1 - 0.053 12.9 0.0 0.067 12.6 0.0 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family adh_short PF00106.20 CCF36786.1 - 4.3e-19 69.0 0.1 5.7e-18 65.3 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF36786.1 - 6.6e-11 42.4 0.0 5.8e-08 32.7 0.0 2.0 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF36786.1 - 3.3e-09 36.6 0.0 4.5e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF36786.1 - 0.00026 20.4 0.0 0.00037 20.0 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF36786.1 - 0.00093 19.2 0.0 0.004 17.1 0.0 2.0 1 1 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 CCF36786.1 - 0.0071 15.3 0.1 0.0099 14.8 0.1 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Polysacc_synt_2 PF02719.10 CCF36786.1 - 0.012 14.5 0.0 0.016 14.1 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 CCF36786.1 - 0.014 14.1 0.1 0.035 12.8 0.1 1.6 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Fungal_trans PF04082.13 CCF36788.1 - 5e-38 130.4 0.1 4.3e-37 127.3 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF36788.1 - 0.0024 17.7 1.3 0.0041 16.9 0.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Crystall PF00030.14 CCF36789.1 - 0.13 12.1 0.1 0.19 11.6 0.1 1.2 1 0 0 1 1 1 0 Beta/Gamma crystallin Sugar_tr PF00083.19 CCF36790.1 - 5.5e-81 272.4 26.0 7.1e-81 272.0 18.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF36790.1 - 1.3e-28 99.7 26.5 1.3e-28 99.7 18.3 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF36790.1 - 5.9e-07 28.0 2.7 1.2e-06 27.0 1.9 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OPT PF03169.10 CCF36791.1 - 1.9e-29 102.6 0.7 2.3e-29 102.3 0.5 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Chs3p PF12271.3 CCF36792.1 - 3.2e-137 456.3 16.5 3.7e-137 456.1 11.4 1.0 1 0 0 1 1 1 1 Chitin synthase III catalytic subunit Cyclin PF08613.6 CCF36794.1 - 3.3e-15 56.7 0.0 5.6e-15 56.0 0.0 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 CCF36794.1 - 0.00016 21.2 0.1 0.00025 20.5 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain YbgT_YccB PF08173.6 CCF36796.1 - 0.11 12.3 1.4 0.24 11.2 1.0 1.6 1 0 0 1 1 1 0 Membrane bound YbgT-like protein 2TM PF13239.1 CCF36796.1 - 0.75 9.9 3.3 1 9.4 2.3 1.2 1 0 0 1 1 1 0 2TM domain FATC PF02260.15 CCF36797.1 - 3.7e-14 51.8 0.1 4.5e-14 51.5 0.1 1.1 1 0 0 1 1 1 1 FATC domain Cullin PF00888.17 CCF36798.1 - 9.9e-123 410.7 0.1 1.6e-122 410.0 0.0 1.3 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 CCF36798.1 - 9.2e-26 89.4 0.9 2.3e-25 88.2 0.7 1.7 1 0 0 1 1 1 1 Cullin protein neddylation domain Ribosomal_L10 PF00466.15 CCF36799.1 - 3.1e-21 75.1 0.0 4.3e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 Lactonase PF10282.4 CCF36801.1 - 1.2e-76 258.1 0.0 1.4e-76 257.8 0.0 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Acetyltransf_3 PF13302.1 CCF36802.1 - 9.1e-12 45.3 0.0 1.8e-11 44.3 0.0 1.5 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CCF36802.1 - 9.7e-08 31.9 0.0 1.3e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF36802.1 - 0.029 14.5 0.0 0.058 13.5 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 CCF36802.1 - 0.03 14.2 0.0 0.092 12.6 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain SCA7 PF08313.7 CCF36803.1 - 3.1e-34 116.4 0.6 3.1e-34 116.4 0.4 1.9 2 0 0 2 2 2 1 SCA7, zinc-binding domain MIP-T3 PF10243.4 CCF36803.1 - 0.0003 19.4 20.5 0.00036 19.1 14.2 1.1 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 zf-C2HC_2 PF13913.1 CCF36803.1 - 0.06 13.0 0.5 0.1 12.2 0.3 1.4 1 0 0 1 1 1 0 zinc-finger of a C2HC-type DUF2457 PF10446.4 CCF36803.1 - 0.17 10.5 24.8 0.015 14.0 13.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) SAPS PF04499.10 CCF36803.1 - 5.3 5.5 5.4 6.6 5.2 3.7 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Menin PF05053.8 CCF36803.1 - 7.8 4.5 10.4 9.8 4.2 7.2 1.2 1 0 0 1 1 1 0 Menin eIF-3c_N PF05470.7 CCF36803.1 - 8.6 4.3 20.6 14 3.6 14.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Alpha-amylase PF00128.19 CCF36805.1 - 0.01 15.2 0.0 0.014 14.8 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_hydro_70 PF02324.11 CCF36805.1 - 0.025 12.3 0.0 0.031 12.0 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 70 Fork_head PF00250.13 CCF36808.1 - 1.3e-11 44.3 0.0 2.8e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 Fork head domain FHA PF00498.21 CCF36808.1 - 5.4e-05 23.2 0.1 0.00011 22.2 0.0 1.5 1 0 0 1 1 1 1 FHA domain HupE_UreJ PF04955.7 CCF36808.1 - 0.29 10.4 1.8 0.52 9.5 1.2 1.3 1 0 0 1 1 1 0 HupE / UreJ protein CAP59_mtransfer PF11735.3 CCF36809.1 - 7.5e-37 126.8 0.0 9.5e-37 126.5 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 YscJ_FliF_C PF08345.6 CCF36810.1 - 0.069 13.1 2.7 0.085 12.8 1.9 1.1 1 0 0 1 1 1 0 Flagellar M-ring protein C-terminal DUF566 PF04484.7 CCF36810.1 - 1.8 7.9 7.0 1.9 7.9 4.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF566) Sporozoite_P67 PF05642.6 CCF36810.1 - 9.3 3.9 9.4 9.4 3.9 6.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TPR_11 PF13414.1 CCF36814.1 - 2.2e-47 158.5 20.0 3.2e-18 65.1 4.1 6.0 4 2 1 5 5 5 5 TPR repeat TPR_1 PF00515.23 CCF36814.1 - 2.5e-37 124.9 13.1 1.6e-06 27.4 0.1 8.5 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.12 CCF36814.1 - 4.1e-37 123.1 11.6 1.9e-06 27.3 0.0 8.4 8 0 0 8 8 8 7 Tetratricopeptide repeat DnaJ PF00226.26 CCF36814.1 - 7e-29 99.3 6.2 6e-28 96.3 3.0 3.0 2 0 0 2 2 2 1 DnaJ domain TPR_16 PF13432.1 CCF36814.1 - 6.4e-24 84.0 6.8 8.9e-06 26.2 0.2 6.2 4 2 1 5 5 5 5 Tetratricopeptide repeat TPR_19 PF14559.1 CCF36814.1 - 3.2e-20 72.2 17.1 9.3e-06 25.8 0.1 6.2 4 2 2 6 6 5 5 Tetratricopeptide repeat TPR_14 PF13428.1 CCF36814.1 - 3.5e-18 64.4 8.9 0.00026 21.3 0.0 8.2 4 3 4 8 8 8 5 Tetratricopeptide repeat TPR_17 PF13431.1 CCF36814.1 - 1.4e-17 62.3 12.2 0.00037 20.4 0.0 7.5 7 0 0 7 7 7 4 Tetratricopeptide repeat Apc3 PF12895.2 CCF36814.1 - 4.4e-17 61.9 6.3 5.5e-09 36.0 0.2 3.7 3 0 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 CCF36814.1 - 3e-14 52.7 17.4 0.00028 20.7 0.2 5.9 4 2 2 6 6 5 5 Tetratricopeptide repeat TPR_9 PF13371.1 CCF36814.1 - 3.5e-12 45.9 6.0 0.012 15.4 0.2 4.9 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.1 CCF36814.1 - 4.5e-12 44.8 18.4 0.0021 17.7 0.0 7.9 8 2 2 10 10 8 3 Tetratricopeptide repeat TPR_7 PF13176.1 CCF36814.1 - 1.2e-10 40.3 8.0 0.34 10.8 0.0 7.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.1 CCF36814.1 - 5.1e-07 29.7 15.4 0.041 14.3 0.0 8.1 9 0 0 9 9 7 1 Tetratricopeptide repeat TPR_15 PF13429.1 CCF36814.1 - 7.6e-05 21.9 8.9 0.16 10.9 0.0 4.6 3 2 1 5 5 5 2 Tetratricopeptide repeat TPR_4 PF07721.9 CCF36814.1 - 0.00019 21.5 2.5 0.11 13.0 0.0 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat NARP1 PF12569.3 CCF36814.1 - 0.00069 18.4 5.3 0.0024 16.7 0.4 3.0 2 1 0 3 3 3 1 NMDA receptor-regulated protein 1 TPR_20 PF14561.1 CCF36814.1 - 0.0028 17.7 10.7 0.91 9.6 0.1 5.0 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.1 CCF36814.1 - 0.0057 16.5 3.3 18 5.4 0.0 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat ChAPs PF09295.5 CCF36814.1 - 0.0084 14.9 0.1 0.016 13.9 0.0 1.4 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) NatB_MDM20 PF09797.4 CCF36814.1 - 0.031 13.0 0.6 0.068 11.8 0.0 1.8 2 0 0 2 2 2 0 N-acetyltransferase B complex (NatB) non catalytic subunit DUF928 PF06051.7 CCF36814.1 - 0.034 13.7 0.2 0.072 12.6 0.1 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) Alkyl_sulf_dimr PF14863.1 CCF36814.1 - 0.035 14.3 4.4 5 7.3 0.0 4.3 3 1 1 4 4 4 0 Alkyl sulfatase dimerisation PPR PF01535.15 CCF36814.1 - 0.044 13.7 0.3 14 5.8 0.0 3.8 4 0 0 4 4 2 0 PPR repeat PS_pyruv_trans PF04230.8 CCF36814.1 - 0.15 11.7 0.2 7.3 6.1 0.0 2.4 2 0 0 2 2 2 0 Polysaccharide pyruvyl transferase RPT PF13446.1 CCF36814.1 - 0.26 10.7 1.3 6.7 6.1 0.0 3.2 4 0 0 4 4 4 0 A repeated domain in UCH-protein TPR_21 PF09976.4 CCF36814.1 - 2.1 8.2 16.7 0.68 9.8 0.6 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat EF-hand_6 PF13405.1 CCF36815.1 - 4e-13 48.0 0.5 1.6e-06 27.5 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 CCF36815.1 - 3.1e-11 41.7 2.5 3.4e-05 22.8 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 CCF36815.1 - 9.8e-10 38.4 3.3 3.9e-07 30.1 0.3 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 CCF36815.1 - 1.6e-07 30.3 6.5 7.7e-05 21.8 0.8 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 CCF36815.1 - 2.6e-07 30.1 1.7 0.0011 18.4 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair Afi1 PF07792.7 CCF36816.1 - 1.5e-64 216.4 0.0 2.8e-64 215.5 0.0 1.5 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.5 CCF36816.1 - 3.2e-36 123.4 0.0 5.9e-36 122.6 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.4 CCF36816.1 - 1.2e-07 30.5 0.0 0.011 14.3 0.0 3.8 3 1 1 4 4 4 2 Transport protein Avl9 DUF2347 PF09804.4 CCF36816.1 - 0.028 13.6 0.0 0.16 11.1 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2347) Ebola_NP PF05505.7 CCF36816.1 - 0.036 12.1 2.8 0.059 11.4 1.9 1.2 1 0 0 1 1 1 0 Ebola nucleoprotein Esterase PF00756.15 CCF36817.1 - 8.8e-52 176.0 0.0 1e-51 175.7 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.2 CCF36817.1 - 1.1e-06 28.6 0.0 1.4e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF36817.1 - 4.8e-06 26.3 0.0 6.1e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase_phd PF10503.4 CCF36817.1 - 1.4e-05 24.4 0.1 9.4e-05 21.7 0.1 2.0 1 1 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.16 CCF36817.1 - 0.0038 16.4 0.0 0.0073 15.5 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.2 CCF36817.1 - 0.0079 15.1 0.0 0.012 14.4 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_2 PF02230.11 CCF36817.1 - 0.022 14.2 0.0 0.033 13.6 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Lipase_3 PF01764.20 CCF36817.1 - 0.043 13.4 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Chlorophyllase PF07224.6 CCF36817.1 - 0.065 12.0 0.0 0.16 10.7 0.0 1.6 2 0 0 2 2 2 0 Chlorophyllase PAF-AH_p_II PF03403.8 CCF36817.1 - 0.074 11.3 0.0 0.11 10.7 0.0 1.2 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II PGAP1 PF07819.8 CCF36817.1 - 0.1 12.1 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein NAD_binding_4 PF07993.7 CCF36818.1 - 1.4e-31 109.3 0.0 2.1e-31 108.7 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Methyltransf_12 PF08242.7 CCF36818.1 - 2.1e-11 44.1 0.0 5e-11 42.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF36818.1 - 1.7e-07 30.9 0.0 3.3e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF36818.1 - 4.6e-07 30.2 0.0 1.9e-06 28.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF36818.1 - 9.6e-07 28.6 0.0 9.5e-06 25.4 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain adh_short PF00106.20 CCF36818.1 - 1.9e-05 24.6 0.0 4.2e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.16 CCF36818.1 - 7.9e-05 22.1 0.0 0.00017 21.0 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_18 PF12847.2 CCF36818.1 - 0.00079 19.9 0.0 0.0023 18.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF36818.1 - 0.001 19.3 0.0 0.003 17.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Polysacc_synt_2 PF02719.10 CCF36818.1 - 0.0024 16.8 0.0 0.014 14.3 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.5 CCF36818.1 - 0.0027 17.3 0.1 0.0096 15.5 0.1 2.0 1 0 0 1 1 1 1 KR domain Methyltransf_26 PF13659.1 CCF36818.1 - 0.011 15.7 0.0 0.041 13.9 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.6 CCF36818.1 - 0.034 13.5 0.0 0.21 10.9 0.0 2.0 2 0 0 2 2 2 0 Nodulation protein S (NodS) DXP_reductoisom PF02670.11 CCF36818.1 - 0.06 13.8 0.0 0.13 12.8 0.0 1.5 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Ubie_methyltran PF01209.13 CCF36818.1 - 0.088 11.9 0.0 1.6 7.7 0.0 2.2 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family RrnaAD PF00398.15 CCF36818.1 - 0.088 11.8 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase adh_short PF00106.20 CCF36819.1 - 6.8e-21 74.8 0.3 2.3e-20 73.1 0.2 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF36819.1 - 2.7e-11 43.7 0.0 3.8e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF36819.1 - 1.8e-07 30.9 0.4 5e-07 29.5 0.3 1.6 1 1 0 1 1 1 1 KR domain CHB_HEX_C_1 PF13290.1 CCF36819.1 - 0.022 14.5 0.0 0.055 13.2 0.0 1.6 1 0 0 1 1 1 0 Chitobiase/beta-hexosaminidase C-terminal domain IlvN PF07991.7 CCF36819.1 - 0.062 12.6 0.0 0.085 12.2 0.0 1.2 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain Cullin_binding PF03556.10 CCF36820.1 - 0.072 13.2 0.2 0.082 13.0 0.1 1.3 1 0 0 1 1 1 0 Cullin binding Peptidase_M43 PF05572.8 CCF36821.1 - 9e-11 41.6 0.1 2e-10 40.4 0.1 1.5 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.1 CCF36821.1 - 0.039 13.8 0.0 0.075 12.9 0.0 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_2 PF13574.1 CCF36821.1 - 0.061 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Clr5 PF14420.1 CCF36823.1 - 4.7e-13 48.8 0.1 6.9e-13 48.2 0.1 1.3 1 0 0 1 1 1 1 Clr5 domain DUF3669 PF12417.3 CCF36825.1 - 5.7e-22 77.2 0.1 1.2e-21 76.2 0.0 1.5 1 0 0 1 1 1 1 Zinc finger protein p450 PF00067.17 CCF36826.1 - 3.6e-17 62.0 0.0 7.6e-17 60.9 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 FlxA PF14282.1 CCF36827.1 - 0.014 15.3 1.6 0.015 15.2 1.1 1.1 1 0 0 1 1 1 0 FlxA-like protein DivIC PF04977.10 CCF36827.1 - 0.022 14.2 1.8 0.04 13.4 1.3 1.4 1 0 0 1 1 1 0 Septum formation initiator YlqD PF11068.3 CCF36827.1 - 0.028 14.4 1.0 0.044 13.8 0.7 1.2 1 0 0 1 1 1 0 YlqD protein DUF4200 PF13863.1 CCF36827.1 - 0.037 13.9 0.6 0.044 13.7 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) bZIP_2 PF07716.10 CCF36827.1 - 0.057 13.2 0.8 0.11 12.3 0.6 1.6 1 0 0 1 1 1 0 Basic region leucine zipper HALZ PF02183.13 CCF36827.1 - 0.13 12.0 0.3 0.24 11.1 0.2 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper K_trans PF02705.11 CCF36828.1 - 8.5e-182 605.2 16.1 1e-181 604.9 11.1 1.0 1 0 0 1 1 1 1 K+ potassium transporter GTP_EFTU PF00009.22 CCF36829.1 - 1.5e-43 148.4 0.0 2.8e-43 147.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.1 CCF36829.1 - 1.7e-22 79.0 0.0 1.1e-21 76.4 0.0 2.2 2 0 0 2 2 2 1 Elongation Factor G, domain II EFG_C PF00679.19 CCF36829.1 - 1.8e-12 46.9 0.0 2.1e-11 43.5 0.0 2.6 1 1 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 CCF36829.1 - 8.6e-05 22.5 0.0 0.00022 21.2 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.13 CCF36829.1 - 0.00016 21.2 0.0 0.00036 20.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV zf-C3HC4_3 PF13920.1 CCF36831.1 - 1.3e-11 43.9 8.3 1.9e-11 43.4 5.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF36831.1 - 6.6e-11 41.8 9.5 1.1e-10 41.1 6.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 CCF36831.1 - 5.4e-09 35.9 9.4 8.5e-09 35.2 6.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF36831.1 - 9.8e-08 31.6 9.6 1.6e-07 30.9 6.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 CCF36831.1 - 3.4e-07 29.7 9.8 5.6e-07 29.1 6.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CCF36831.1 - 1.2e-05 25.0 3.5 2.3e-05 24.1 2.4 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 CCF36831.1 - 0.00028 20.3 5.4 0.00051 19.5 3.7 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.1 CCF36831.1 - 0.0005 19.7 3.1 0.0005 19.7 2.1 2.3 1 1 1 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.1 CCF36831.1 - 0.0015 18.0 7.1 0.0066 15.9 4.9 2.0 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.1 CCF36831.1 - 0.0035 17.1 8.2 0.006 16.4 5.7 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 CCF36831.1 - 0.0048 16.9 3.5 0.012 15.7 2.4 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger TerY-C PF15616.1 CCF36831.1 - 0.045 13.6 1.8 0.079 12.8 1.2 1.4 1 0 0 1 1 1 0 TerY-C metal binding domain zf-RING_6 PF14835.1 CCF36831.1 - 0.1 12.4 2.8 0.19 11.5 1.9 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein PolC_DP2 PF03833.8 CCF36831.1 - 0.2 9.2 2.4 0.27 8.8 1.7 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-MIZ PF02891.15 CCF36831.1 - 0.29 10.6 7.3 0.56 9.7 5.1 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-P11 PF03854.9 CCF36831.1 - 0.83 9.1 5.1 1.5 8.3 3.5 1.4 1 0 0 1 1 1 0 P-11 zinc finger DUF329 PF03884.9 CCF36831.1 - 2.6 7.6 5.7 0.67 9.5 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF329) zf-FCS PF06467.9 CCF36831.1 - 8.3 6.1 8.0 4.9 6.8 0.3 2.4 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif PI-PLC-Y PF00387.14 CCF36833.1 - 2.8e-23 82.1 0.0 4.1e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.25 CCF36833.1 - 0.0009 19.0 1.7 0.0027 17.5 0.2 2.4 2 1 0 2 2 2 1 C2 domain Glyco_hydro_28 PF00295.12 CCF36834.1 - 8e-45 153.1 3.0 1.2e-44 152.6 2.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 VWA_3 PF13768.1 CCF36836.1 - 1.2e-24 86.8 0.0 1.3e-23 83.3 0.0 2.6 2 1 0 2 2 2 1 von Willebrand factor type A domain VIT PF08487.5 CCF36836.1 - 2.6e-17 62.6 0.0 5.1e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_2 PF13519.1 CCF36836.1 - 1.8e-15 57.5 0.0 2.8e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 CCF36836.1 - 3.3e-12 46.4 0.0 5.3e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.1 CCF36836.1 - 1.7e-06 27.3 0.0 3.4e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain vWA-TerF-like PF10138.4 CCF36836.1 - 0.00019 21.3 0.0 0.00033 20.5 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA_CoxE PF05762.9 CCF36836.1 - 0.024 13.7 0.0 2.9 6.9 0.0 2.2 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein Mog1 PF04603.7 CCF36841.1 - 3.3e-17 62.7 0.0 4.7e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Ran-interacting Mog1 protein SprT-like PF10263.4 CCF36842.1 - 1.1e-50 171.3 3.1 2.3e-50 170.3 2.2 1.5 1 0 0 1 1 1 1 SprT-like family HMG_box PF00505.14 CCF36842.1 - 0.00026 21.1 1.8 0.0004 20.5 0.1 2.2 2 0 0 2 2 2 1 HMG (high mobility group) box DUF4379 PF14311.1 CCF36842.1 - 0.077 12.8 1.7 0.3 10.9 1.2 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4379) Peptidase_M90 PF06167.7 CCF36842.1 - 0.096 12.0 0.1 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Glucose-regulated metallo-peptidase M90 Zn-ribbon_8 PF09723.5 CCF36842.1 - 0.13 12.2 1.4 0.34 10.9 1.0 1.7 1 0 0 1 1 1 0 Zinc ribbon domain Porin_3 PF01459.17 CCF36844.1 - 1.7e-61 207.9 11.1 1.9e-61 207.7 7.7 1.0 1 0 0 1 1 1 1 Eukaryotic porin Asn_synthase PF00733.16 CCF36845.1 - 1.8e-69 234.0 0.0 2.5e-69 233.6 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 CCF36845.1 - 2e-39 134.1 0.0 3.1e-39 133.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 CCF36845.1 - 8.8e-31 106.6 0.0 2.3e-30 105.2 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.3 CCF36845.1 - 9.4e-10 38.0 0.0 1.7e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.12 CCF36845.1 - 0.00057 18.8 0.0 0.0021 17.0 0.0 1.8 1 1 0 1 1 1 1 NAD synthase GATase_2 PF00310.16 CCF36845.1 - 0.00067 18.4 0.0 0.09 11.4 0.0 2.4 1 1 1 2 2 2 2 Glutamine amidotransferases class-II AA_permease PF00324.16 CCF36847.1 - 5.1e-90 302.1 33.6 6.2e-90 301.8 23.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF36847.1 - 1.2e-24 86.6 35.0 1.5e-24 86.3 24.3 1.0 1 0 0 1 1 1 1 Amino acid permease DUF1772 PF08592.6 CCF36847.1 - 2.3 7.9 9.7 0.76 9.5 0.4 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) zf-C2H2_3 PF13878.1 CCF36850.1 - 1.7e-05 24.2 0.3 1.8e-05 24.1 0.2 1.1 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Rubredoxin PF00301.15 CCF36850.1 - 0.15 11.9 0.1 0.16 11.8 0.1 1.1 1 0 0 1 1 1 0 Rubredoxin Vma12 PF11712.3 CCF36851.1 - 6.9e-36 123.0 0.0 9.7e-36 122.5 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase polyprenyl_synt PF00348.12 CCF36852.1 - 2.3e-54 183.9 0.0 1.7e-51 174.5 0.0 2.1 2 0 0 2 2 2 2 Polyprenyl synthetase HEPPP_synt_1 PF07307.6 CCF36852.1 - 0.014 14.8 0.0 0.022 14.2 0.0 1.2 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 MFS_1 PF07690.11 CCF36855.1 - 3.1e-19 68.8 65.6 2.6e-11 42.8 22.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CCF36855.1 - 1.5e-06 26.8 12.0 1.5e-06 26.8 8.3 2.7 1 1 1 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.2 CCF36855.1 - 0.0012 18.5 0.9 0.0035 17.1 0.0 2.3 2 0 0 2 2 2 1 MFS_1 like family Peptidase_M43 PF05572.8 CCF36856.1 - 5.3e-12 45.5 0.4 1.5e-11 44.1 0.1 1.8 2 0 0 2 2 2 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.1 CCF36856.1 - 6.6e-05 22.9 0.5 0.00017 21.6 0.3 1.6 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.1 CCF36856.1 - 0.0025 18.3 0.4 0.0065 16.9 0.3 1.7 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.19 CCF36856.1 - 0.0047 16.3 0.0 0.0098 15.3 0.0 1.4 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Reprolysin_2 PF13574.1 CCF36856.1 - 0.0099 15.9 0.9 0.019 15.0 0.6 1.6 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.4 CCF36856.1 - 0.018 13.9 0.7 0.03 13.1 0.5 1.3 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_4 PF13583.1 CCF36856.1 - 0.07 12.6 0.1 0.12 11.8 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.19 CCF36856.1 - 0.075 12.7 0.1 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Matrixin PI3_PI4_kinase PF00454.22 CCF36857.1 - 2.7e-31 108.8 0.0 4.4e-31 108.1 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.3 CCF36857.1 - 1.9e-19 69.1 0.0 3.9e-19 68.1 0.0 1.6 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 Med3 PF11593.3 CCF36857.1 - 0.039 13.2 0.0 0.039 13.2 0.0 2.6 2 1 1 3 3 3 0 Mediator complex subunit 3 fungal PI3Ka PF00613.15 CCF36857.1 - 0.16 11.1 0.5 0.3 10.2 0.4 1.4 1 0 0 1 1 1 0 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Acetyltransf_1 PF00583.19 CCF36858.1 - 2.8e-08 33.6 0.0 4.4e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 CCF36858.1 - 0.049 13.5 0.0 0.079 12.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Hexokinase_1 PF00349.16 CCF36859.1 - 6.4e-65 218.3 0.0 1.3e-64 217.3 0.0 1.4 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.11 CCF36859.1 - 1.6e-62 210.9 0.0 2.9e-62 210.0 0.0 1.4 1 1 0 1 1 1 1 Hexokinase p450 PF00067.17 CCF36860.1 - 6.8e-10 38.0 0.0 8.5e-10 37.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 NAGLU_N PF12971.2 CCF36860.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Abhydrolase_6 PF12697.2 CCF36861.1 - 1.5e-21 77.3 0.5 2.3e-21 76.7 0.4 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF36861.1 - 1.2e-10 41.2 0.1 2e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF36861.1 - 0.0018 17.8 0.0 0.51 9.8 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Thioesterase PF00975.15 CCF36861.1 - 0.0049 17.1 0.0 0.012 15.8 0.0 1.6 1 1 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.8 CCF36861.1 - 0.012 15.1 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Lipase_3 PF01764.20 CCF36861.1 - 0.095 12.3 0.1 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_4 PF08386.5 CCF36861.1 - 0.13 12.1 0.1 0.8 9.6 0.0 2.0 2 0 0 2 2 2 0 TAP-like protein TRP PF06011.7 CCF36862.1 - 2.2e-66 224.2 0.7 2.8e-66 223.9 0.5 1.0 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel 2OG-FeII_Oxy_3 PF13640.1 CCF36865.1 - 0.00064 20.1 0.0 0.0011 19.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Tenui_NCP PF04876.7 CCF36865.1 - 0.032 13.7 0.0 0.046 13.2 0.0 1.2 1 0 0 1 1 1 0 Tenuivirus major non-capsid protein 2OG-FeII_Oxy PF03171.15 CCF36865.1 - 0.046 14.0 0.0 0.093 13.0 0.0 1.5 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Methyltransf_23 PF13489.1 CCF36866.1 - 7.6e-19 67.9 0.0 1.3e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF36866.1 - 1.6e-09 37.5 0.0 5e-09 35.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF36866.1 - 7.5e-09 35.9 0.0 1.3e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF36866.1 - 1.5e-07 31.7 0.0 1.5e-06 28.5 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF36866.1 - 1.8e-07 31.7 0.0 1.7e-06 28.5 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF36866.1 - 9.7e-05 22.6 0.0 0.00022 21.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF36866.1 - 0.00044 19.6 0.0 0.00072 18.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.14 CCF36866.1 - 0.011 15.7 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase PrmA PF06325.8 CCF36866.1 - 0.011 14.9 0.0 0.016 14.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.12 CCF36866.1 - 0.027 13.5 0.0 0.061 12.3 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_2 PF00891.13 CCF36866.1 - 0.033 13.3 0.0 0.059 12.5 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_26 PF13659.1 CCF36866.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.15 CCF36866.1 - 0.1 11.6 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Bystin PF05291.6 CCF36868.1 - 1.4e-121 405.1 0.0 1.8e-121 404.7 0.0 1.1 1 0 0 1 1 1 1 Bystin DUF383 PF04063.9 CCF36869.1 - 1.8e-67 226.6 0.4 7.2e-67 224.6 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF383) DUF384 PF04064.8 CCF36869.1 - 3e-23 81.1 0.2 8e-23 79.7 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF384) Proteasom_PSMB PF10508.4 CCF36869.1 - 5.2e-05 21.7 0.0 0.00097 17.5 0.1 2.3 2 1 1 3 3 3 1 Proteasome non-ATPase 26S subunit V-ATPase_H_N PF03224.9 CCF36869.1 - 0.0034 16.5 0.2 0.0054 15.8 0.1 1.4 1 1 0 1 1 1 1 V-ATPase subunit H DUF427 PF04248.7 CCF36870.1 - 9e-32 108.6 1.1 1e-31 108.4 0.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF427) DUF221 PF02714.10 CCF36871.1 - 4.7e-99 331.3 19.0 4.7e-99 331.3 13.2 2.2 2 0 0 2 2 2 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 CCF36871.1 - 1.4e-38 131.8 0.1 1.4e-38 131.8 0.1 2.6 2 1 2 4 4 4 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 CCF36871.1 - 3.7e-18 65.1 0.0 1.1e-17 63.6 0.0 1.8 1 0 0 1 1 1 1 Phosphate metabolism protein DUF4463 PF14703.1 CCF36871.1 - 1.4e-07 31.9 8.4 0.0027 18.1 3.5 2.9 3 0 0 3 3 3 2 Domain of unknown function (DUF4463) FAD_binding_3 PF01494.14 CCF36872.1 - 8.3e-11 41.5 0.0 9.8e-11 41.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 CCF36872.1 - 1.6e-07 31.2 0.4 3.4e-07 30.2 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CCF36872.1 - 0.0012 17.7 0.8 0.0021 16.9 0.6 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF36872.1 - 0.0028 16.6 1.8 0.0047 15.8 1.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF36872.1 - 0.0032 17.3 0.7 0.005 16.7 0.5 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.16 CCF36872.1 - 0.0098 15.7 0.3 0.017 14.9 0.2 1.4 1 0 0 1 1 1 1 ThiF family Pyr_redox PF00070.22 CCF36872.1 - 0.037 14.4 0.0 0.097 13.0 0.0 1.7 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF36872.1 - 0.045 13.8 0.2 0.055 13.5 0.1 1.4 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CCF36872.1 - 0.051 12.4 1.1 0.07 11.9 0.7 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A Thi4 PF01946.12 CCF36872.1 - 0.055 12.5 0.1 0.1 11.6 0.1 1.4 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.9 CCF36872.1 - 0.09 11.2 0.5 0.13 10.7 0.4 1.1 1 0 0 1 1 1 0 HI0933-like protein 3HCDH_N PF02737.13 CCF36872.1 - 0.15 11.6 1.0 0.24 11.0 0.7 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 CCF36872.1 - 0.18 11.1 1.7 0.21 10.9 0.4 1.6 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_9 PF13454.1 CCF36872.1 - 0.19 11.5 0.3 0.35 10.6 0.2 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding F420_oxidored PF03807.12 CCF36872.1 - 0.31 11.4 1.0 0.72 10.3 0.7 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent TMEM154 PF15102.1 CCF36874.1 - 0.0018 18.0 0.0 0.0033 17.1 0.0 1.5 1 0 0 1 1 1 1 TMEM154 protein family DUF4448 PF14610.1 CCF36874.1 - 0.012 15.0 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Shisa PF13908.1 CCF36874.1 - 0.27 11.3 0.1 0.27 11.3 0.0 2.3 2 1 0 2 2 2 0 Wnt and FGF inhibitory regulator EphA2_TM PF14575.1 CCF36874.1 - 0.6 10.5 2.4 0.35 11.2 0.2 1.7 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain ALAD PF00490.16 CCF36875.1 - 2.9e-118 394.4 0.0 3.4e-118 394.2 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Inhibitor_I9 PF05922.11 CCF36877.1 - 7.1e-08 32.9 0.1 1e-07 32.3 0.1 1.2 1 0 0 1 1 1 1 Peptidase inhibitor I9 YlbD_coat PF14071.1 CCF36879.1 - 0.043 13.8 0.0 0.063 13.3 0.0 1.2 1 0 0 1 1 1 0 Putative coat protein Citrate_synt PF00285.16 CCF36882.1 - 6.9e-20 71.0 0.0 3.4e-17 62.2 0.0 2.9 1 1 1 2 2 2 2 Citrate synthase CoA_binding PF02629.14 CCF36882.1 - 3.7e-18 65.8 0.0 1.2e-17 64.1 0.0 2.0 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.14 CCF36882.1 - 3.2e-14 52.7 0.1 5.2e-14 52.1 0.1 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.1 CCF36882.1 - 7.4e-05 22.3 0.0 0.00066 19.3 0.0 2.2 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain RdRP PF05183.7 CCF36884.1 - 1e-116 390.9 0.2 1.5e-116 390.3 0.1 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase MFS_1 PF07690.11 CCF36887.1 - 1.6e-21 76.4 7.3 1.6e-21 76.4 5.1 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Sensor PF13796.1 CCF36887.1 - 6.3e-06 25.9 2.9 6.3e-06 25.9 2.0 2.5 1 1 0 2 2 2 1 Putative sensor PhaG_MnhG_YufB PF03334.9 CCF36887.1 - 1.5 8.8 11.3 1.1 9.4 4.3 2.6 2 1 0 2 2 2 0 Na+/H+ antiporter subunit CSTF2_hinge PF14327.1 CCF36888.1 - 1.2e-30 105.4 2.2 1.9e-30 104.7 1.5 1.3 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.17 CCF36888.1 - 5.2e-22 77.2 0.0 8.5e-22 76.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF36888.1 - 4e-16 58.7 0.0 7.8e-16 57.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF36888.1 - 5.4e-08 32.5 0.0 7.8e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.1 CCF36888.1 - 6.2e-07 28.5 3.6 6.2e-07 28.5 2.5 2.8 3 0 0 3 3 3 1 Transcription termination and cleavage factor C-terminal Spo7_2_N PF15407.1 CCF36888.1 - 0.097 12.1 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Sporulation protein family 7 COPIIcoated_ERV PF07970.7 CCF36889.1 - 1.5e-74 250.4 1.7 2.6e-50 171.1 1.2 2.2 2 0 0 2 2 2 2 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 CCF36889.1 - 1.6e-34 117.7 0.1 6.1e-34 115.8 0.0 1.9 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Steroid_dh PF02544.11 CCF36891.1 - 2.6e-32 111.6 0.6 3.6e-32 111.2 0.4 1.2 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.7 CCF36891.1 - 0.00022 20.5 1.7 0.0015 17.9 0.4 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1295) PEMT PF04191.8 CCF36891.1 - 0.012 15.7 0.3 0.057 13.5 0.1 2.1 2 0 0 2 2 2 0 Phospholipid methyltransferase Flavi_NS4B PF01349.12 CCF36891.1 - 0.019 13.8 0.0 3.5 6.4 0.0 2.3 2 0 0 2 2 2 0 Flavivirus non-structural protein NS4B GCN5L1 PF06320.8 CCF36892.1 - 1.3e-08 34.6 0.6 2.1e-08 34.0 0.4 1.2 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) HAUS6_N PF14661.1 CCF36892.1 - 0.016 14.5 1.0 0.025 13.9 0.7 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus eIF3_N PF09440.5 CCF36892.1 - 0.018 15.2 0.2 0.028 14.5 0.1 1.2 1 0 0 1 1 1 0 eIF3 subunit 6 N terminal domain TFIIA PF03153.8 CCF36892.1 - 0.034 14.0 1.5 0.037 13.9 1.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Serglycin PF04360.7 CCF36892.1 - 0.062 13.0 0.0 0.062 13.0 0.0 1.9 2 0 0 2 2 2 0 Serglycin DUF605 PF04652.11 CCF36892.1 - 0.9 8.8 14.9 1.2 8.4 10.3 1.1 1 0 0 1 1 1 0 Vta1 like DUF1993 PF09351.5 CCF36893.1 - 2.2e-47 161.0 0.0 2.5e-47 160.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) DinB PF05163.7 CCF36893.1 - 0.049 13.3 0.0 0.067 12.9 0.0 1.3 1 1 0 1 1 1 0 DinB family PBP_like_2 PF12849.2 CCF36893.1 - 0.08 12.3 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 PBP superfamily domain FAM117 PF15388.1 CCF36893.1 - 0.11 11.6 0.0 0.16 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein Family FAM117 SOG2 PF10428.4 CCF36894.1 - 1.6e-95 320.4 0.0 4.1e-95 319.0 0.0 1.7 1 0 0 1 1 1 1 RAM signalling pathway protein LRR_4 PF12799.2 CCF36894.1 - 1.1e-16 60.0 2.9 4.8e-07 29.2 0.1 3.9 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CCF36894.1 - 2.8e-16 59.0 0.7 8.5e-10 38.2 0.0 2.5 2 0 0 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 CCF36894.1 - 5.4e-10 37.8 3.2 0.22 11.6 0.1 6.1 6 0 0 6 6 6 3 Leucine Rich Repeat LRR_7 PF13504.1 CCF36894.1 - 3.1e-06 26.5 0.2 2.7 8.5 0.0 5.6 5 0 0 5 5 5 1 Leucine rich repeat LRR_6 PF13516.1 CCF36894.1 - 0.0013 18.5 3.7 4.7 7.6 0.1 4.5 4 0 0 4 4 4 2 Leucine Rich repeat TMEM51 PF15345.1 CCF36896.1 - 0.0049 16.5 0.0 0.0056 16.4 0.0 1.1 1 0 0 1 1 1 1 Transmembrane protein 51 DUF3357 PF11837.3 CCF36896.1 - 0.13 12.0 0.0 0.16 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) zf-CCHC PF00098.18 CCF36900.1 - 0.03 14.2 1.3 0.03 14.2 0.9 5.5 5 0 0 5 5 5 0 Zinc knuckle zf-CCHC_2 PF13696.1 CCF36900.1 - 0.42 10.1 10.1 0.36 10.3 0.1 3.1 2 1 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.1 CCF36900.1 - 0.65 9.7 32.4 0.62 9.7 0.3 5.3 4 1 1 5 5 5 0 Zinc knuckle Ank_2 PF12796.2 CCF36902.1 - 2e-10 40.8 0.0 4.9e-10 39.6 0.0 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 CCF36902.1 - 7.6e-09 34.9 0.1 0.01 15.6 0.0 3.7 3 1 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 CCF36902.1 - 1.4e-08 34.1 0.0 0.019 15.1 0.0 3.8 3 1 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 CCF36902.1 - 2.7e-07 30.9 0.0 2.1e-05 24.9 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF36902.1 - 3.2e-06 27.1 0.2 0.31 11.3 0.0 4.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) TFIIS_C PF01096.13 CCF36903.1 - 5e-21 74.0 3.1 5e-21 74.0 2.2 2.6 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 CCF36903.1 - 2e-06 27.3 2.1 1.2e-05 24.8 0.2 2.5 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.2 CCF36903.1 - 0.0021 17.8 4.8 0.082 12.7 0.2 2.4 2 1 0 2 2 2 2 Transposase zinc-ribbon domain Desulfoferrod_N PF06397.7 CCF36903.1 - 0.01 15.2 0.7 0.088 12.2 0.1 2.3 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain Zn_ribbon_recom PF13408.1 CCF36903.1 - 0.51 10.6 3.8 0.87 9.8 0.1 2.4 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain C1_3 PF07649.7 CCF36903.1 - 0.64 10.1 0.2 0.64 10.1 0.1 2.5 3 0 0 3 3 3 0 C1-like domain IBR PF01485.16 CCF36903.1 - 1.6 8.6 9.0 10 6.1 0.2 2.9 2 1 0 2 2 2 0 IBR domain DZR PF12773.2 CCF36903.1 - 1.7 8.5 6.7 2.8 7.8 0.1 2.5 2 1 0 2 2 2 0 Double zinc ribbon zf-HIT PF04438.11 CCF36903.1 - 7.7 6.2 6.9 7.3 6.3 0.2 3.1 3 0 0 3 3 3 0 HIT zinc finger Med31 PF05669.7 CCF36904.1 - 2.7e-36 123.3 0.1 3e-36 123.2 0.1 1.0 1 0 0 1 1 1 1 SOH1 F-box-like PF12937.2 CCF36906.1 - 0.0087 15.7 0.1 0.039 13.6 0.0 2.2 2 1 0 2 2 2 1 F-box-like CITED PF04487.7 CCF36907.1 - 7.1 6.7 9.2 8.6 6.5 6.4 1.2 1 0 0 1 1 1 0 CITED TMEM138 PF14935.1 CCF36908.1 - 0.41 11.0 9.3 0.38 11.1 5.6 1.6 2 1 0 2 2 2 0 Transmembrane protein 138 DUF4006 PF13179.1 CCF36909.1 - 0.17 11.4 0.2 0.32 10.5 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF4006) DUF4179 PF13786.1 CCF36909.1 - 0.19 11.9 0.1 0.63 10.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) DUF1469 PF07332.6 CCF36909.1 - 8.2 6.1 9.7 0.44 10.2 2.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) Neuregulin PF02158.10 CCF36910.1 - 0.15 10.8 1.7 0.24 10.1 1.2 1.2 1 0 0 1 1 1 0 Neuregulin family HeLo PF14479.1 CCF36911.1 - 3.6e-07 30.1 0.1 4.3e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Prion-inhibition and propagation Osmo_CC PF08946.5 CCF36911.1 - 0.017 15.1 0.5 0.029 14.4 0.3 1.3 1 0 0 1 1 1 0 Osmosensory transporter coiled coil DUF2573 PF10835.3 CCF36911.1 - 0.017 15.1 0.9 0.07 13.1 0.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2573) DUF2465 PF10239.4 CCF36911.1 - 0.089 11.9 0.1 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2465) Laminin_II PF06009.7 CCF36911.1 - 0.09 12.5 0.1 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Laminin Domain II Pkinase PF00069.20 CCF36912.1 - 3.4e-27 95.2 0.0 6.2e-27 94.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF36912.1 - 1.8e-14 53.4 0.0 5.4e-14 51.8 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 CCF36912.1 - 0.0042 16.1 0.0 0.0081 15.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CCF36912.1 - 0.019 14.6 0.8 0.1 12.3 0.1 2.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family CENP-T PF15511.1 CCF36912.1 - 0.02 14.1 10.4 0.026 13.8 7.2 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T CobT PF06213.7 CCF36912.1 - 0.076 12.1 10.9 0.13 11.4 7.5 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pox_ser-thr_kin PF05445.6 CCF36912.1 - 0.078 11.7 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Nucleo_P87 PF07267.6 CCF36912.1 - 0.16 10.5 2.5 0.23 10.1 1.7 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Sigma70_ner PF04546.8 CCF36912.1 - 0.26 10.8 9.5 0.4 10.2 6.6 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF2457 PF10446.4 CCF36912.1 - 0.34 9.5 15.6 0.56 8.8 10.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Daxx PF03344.10 CCF36912.1 - 0.36 9.2 17.1 0.49 8.8 11.9 1.2 1 0 0 1 1 1 0 Daxx Family RRN3 PF05327.6 CCF36912.1 - 0.36 8.8 1.7 0.46 8.5 1.2 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.7 CCF36912.1 - 0.41 8.4 15.4 0.6 7.9 10.7 1.1 1 0 0 1 1 1 0 Nop14-like family Paf1 PF03985.8 CCF36912.1 - 0.71 8.5 11.7 1 8.0 8.1 1.3 1 0 0 1 1 1 0 Paf1 CDC45 PF02724.9 CCF36912.1 - 1.5 6.7 7.9 2 6.3 5.5 1.1 1 0 0 1 1 1 0 CDC45-like protein YqfQ PF14181.1 CCF36912.1 - 1.8 8.6 5.5 5.5 6.9 3.8 1.8 1 0 0 1 1 1 0 YqfQ-like protein DUF2890 PF11081.3 CCF36912.1 - 7.9 6.4 12.6 14 5.6 8.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Oxidored_q6 PF01058.17 CCF36914.1 - 7e-22 77.4 0.0 9.8e-22 76.9 0.0 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Fungal_trans_2 PF11951.3 CCF36915.1 - 4.5e-09 35.3 1.1 6.3e-09 34.9 0.8 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF36915.1 - 1.5e-07 31.2 12.5 2.5e-07 30.4 8.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pro_dh PF01619.13 CCF36917.1 - 4.4e-42 144.1 0.0 6e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase AP_endonuc_2 PF01261.19 CCF36917.1 - 0.03 13.6 0.0 0.054 12.7 0.0 1.5 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel TauD PF02668.11 CCF36917.1 - 0.055 13.1 0.0 0.091 12.4 0.0 1.3 1 0 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family Glyco_transf_22 PF03901.12 CCF36918.1 - 2.5e-84 283.7 15.2 2.9e-84 283.5 10.5 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family GMC_oxred_N PF00732.14 CCF36919.1 - 1.4e-56 191.8 0.0 3.9e-56 190.3 0.0 1.6 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF36919.1 - 5.3e-37 127.3 0.0 1e-36 126.4 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 CCF36919.1 - 2.1e-06 26.9 0.8 0.00034 19.6 0.0 2.4 2 1 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 CCF36919.1 - 7.9e-05 21.7 0.2 0.00016 20.6 0.0 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_3 PF13738.1 CCF36919.1 - 0.0039 17.2 0.4 0.12 12.3 0.1 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF36919.1 - 0.018 15.0 0.9 0.058 13.4 0.5 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF36919.1 - 0.044 13.6 0.1 0.42 10.4 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF36919.1 - 0.1 11.4 0.8 0.14 11.0 0.1 1.5 2 0 0 2 2 2 0 FAD binding domain NAD_binding_9 PF13454.1 CCF36919.1 - 0.38 10.5 2.6 1.2 8.8 0.1 2.7 3 0 0 3 3 3 0 FAD-NAD(P)-binding GIDA PF01134.17 CCF36919.1 - 0.5 9.1 2.6 8.1 5.1 0.5 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Trp_halogenase PF04820.9 CCF36919.1 - 0.53 8.8 2.3 0.47 9.0 0.4 1.8 3 0 0 3 3 3 0 Tryptophan halogenase GMC_oxred_C PF05199.8 CCF36920.1 - 1.1e-20 74.4 0.4 1.8e-20 73.6 0.3 1.5 1 1 0 1 1 1 1 GMC oxidoreductase DUF4050 PF13259.1 CCF36921.1 - 7.5e-35 119.5 0.4 4.3e-34 117.0 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF4050) Spore_coat_CotO PF14153.1 CCF36921.1 - 0.58 9.5 8.5 0.17 11.3 2.6 2.1 2 0 0 2 2 2 0 Spore coat protein CotO COX4 PF02936.9 CCF36922.1 - 3.7e-50 169.3 0.0 4.3e-50 169.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV Alpha-amylase_C PF02806.13 CCF36923.1 - 2.6e-26 91.5 0.1 4.8e-26 90.7 0.1 1.5 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Hexapep_2 PF14602.1 CCF36924.1 - 4.1e-14 51.8 7.4 1.2e-10 40.7 2.1 3.5 3 0 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.19 CCF36924.1 - 2.2e-13 49.0 13.0 1.7e-10 39.9 2.7 3.7 4 0 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Mac PF12464.3 CCF36924.1 - 3.1e-09 36.7 0.0 4.8e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Maltose acetyltransferase Tmemb_170 PF10190.4 CCF36925.1 - 0.003 17.6 10.5 0.0038 17.2 7.3 1.1 1 0 0 1 1 1 1 Putative transmembrane protein 170 DUF2613 PF11021.3 CCF36925.1 - 0.46 10.2 5.2 1.3 8.7 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) PS-DH PF14765.1 CCF36927.1 - 4.7e-59 199.9 0.0 8.8e-59 199.0 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.16 CCF36927.1 - 2.1e-53 181.7 0.1 3.2e-53 181.1 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain ADH_zinc_N PF00107.21 CCF36927.1 - 2.7e-22 78.7 0.2 1.8e-19 69.5 0.1 2.9 2 0 0 2 2 2 2 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF36927.1 - 1.6e-14 54.8 0.0 1.3e-12 48.6 0.0 3.5 3 1 0 3 3 3 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF36927.1 - 1.5e-06 27.9 0.6 3.3e-06 26.8 0.4 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_23 PF13489.1 CCF36927.1 - 2.9e-06 27.1 0.0 7.8e-06 25.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.14 CCF36927.1 - 0.08 12.4 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Lyase_1 PF00206.15 CCF36928.1 - 9.6e-87 291.0 0.0 1.2e-86 290.7 0.0 1.1 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.1 CCF36928.1 - 1.2e-24 86.1 0.0 2.2e-24 85.3 0.0 1.5 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal DUF427 PF04248.7 CCF36929.1 - 2.8e-35 119.8 0.6 5.3e-29 99.7 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF427) DUF3425 PF11905.3 CCF36930.1 - 5.5e-05 23.0 0.0 6.4e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) tRNA-synt_2 PF00152.15 CCF36931.1 - 3.6e-66 223.2 0.0 6.3e-66 222.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 CCF36931.1 - 0.11 11.6 0.0 2.3 7.3 0.0 2.1 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) ATP-sulfurylase PF01747.12 CCF36933.1 - 6.8e-87 290.2 0.2 9.4e-87 289.8 0.1 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.15 CCF36933.1 - 1.1e-57 194.0 0.0 1.7e-57 193.4 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.1 CCF36933.1 - 2e-53 180.0 0.0 3.3e-53 179.3 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain KTI12 PF08433.5 CCF36933.1 - 0.026 13.7 0.0 0.039 13.1 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_33 PF13671.1 CCF36933.1 - 0.055 13.3 0.2 0.12 12.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain Alpha-amylase PF00128.19 CCF36934.1 - 1.8e-60 205.0 1.4 2.5e-60 204.5 0.9 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.6 CCF36934.1 - 1.9e-23 82.3 0.0 3.6e-23 81.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) Glyco_hydro_3 PF00933.16 CCF36938.1 - 1.7e-83 280.0 0.0 2.3e-83 279.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 CCF36938.1 - 5.4e-64 215.8 0.3 2.4e-62 210.4 0.1 2.6 2 1 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 CCF36938.1 - 4.1e-23 81.0 0.1 1e-22 79.8 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.7 CCF36938.1 - 1.3e-18 67.0 0.0 2.2e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 PA14 domain Metallophos PF00149.23 CCF36939.1 - 1.4e-12 47.4 4.2 7.3e-12 45.0 2.9 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase NAPRTase PF04095.11 CCF36941.1 - 6.1e-36 123.9 0.1 1.1e-35 123.0 0.1 1.4 1 1 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family CP2 PF04516.10 CCF36941.1 - 0.089 11.8 0.1 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 CP2 transcription factor WSC PF01822.14 CCF36942.1 - 1.6e-18 66.3 6.6 1.6e-18 66.3 4.6 2.4 3 0 0 3 3 3 1 WSC domain REV PF00424.13 CCF36943.1 - 0.059 13.2 2.9 0.13 12.1 1.0 2.0 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) RCC1 PF00415.13 CCF36944.1 - 1.8e-32 111.2 5.9 7.2e-07 29.3 0.0 8.3 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CCF36944.1 - 1.6e-14 53.0 25.8 1.5e-10 40.3 0.0 7.5 7 2 0 7 7 7 3 Regulator of chromosome condensation (RCC1) repeat NmrA PF05368.8 CCF36946.1 - 2.2e-26 92.5 0.0 2.8e-26 92.2 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF36946.1 - 2.8e-13 50.2 1.3 4.1e-13 49.7 0.9 1.3 1 0 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 CCF36946.1 - 3.2e-05 23.8 0.7 0.00028 20.8 0.1 2.2 1 1 1 2 2 2 1 short chain dehydrogenase KR PF08659.5 CCF36946.1 - 3.5e-05 23.5 0.1 0.00021 20.9 0.0 2.0 1 1 1 2 2 2 1 KR domain Semialdhyde_dh PF01118.19 CCF36946.1 - 0.013 15.8 0.2 0.022 15.0 0.1 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain OHCU_decarbox PF09349.5 CCF36946.1 - 0.019 15.2 0.0 0.03 14.6 0.0 1.2 1 0 0 1 1 1 0 OHCU decarboxylase DapB_N PF01113.15 CCF36946.1 - 0.028 14.3 0.1 0.096 12.6 0.1 1.9 1 1 1 2 2 2 0 Dihydrodipicolinate reductase, N-terminus DUF1365 PF07103.6 CCF36948.1 - 2.7e-33 115.1 0.0 5.7e-33 114.0 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1365) NAS PF03059.11 CCF36949.1 - 2.2e-43 148.4 0.0 2.8e-43 148.0 0.0 1.0 1 0 0 1 1 1 1 Nicotianamine synthase protein Methyltransf_31 PF13847.1 CCF36949.1 - 1e-08 34.9 0.0 3.2e-08 33.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF36949.1 - 0.00026 21.5 0.0 0.00066 20.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF36949.1 - 0.002 18.4 0.0 0.0047 17.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF36949.1 - 0.05 14.0 0.0 0.15 12.5 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 CCF36949.1 - 0.14 11.1 0.1 0.3 10.0 0.0 1.5 1 1 0 1 1 1 0 NNMT/PNMT/TEMT family ATG16 PF08614.6 CCF36951.1 - 6.9e-05 22.7 2.6 0.00013 21.8 1.8 1.4 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) IncA PF04156.9 CCF36951.1 - 9.8e-05 22.0 5.8 0.00017 21.2 4.0 1.3 1 0 0 1 1 1 1 IncA protein CCDC92 PF14916.1 CCF36951.1 - 0.00081 18.9 1.8 0.0021 17.6 1.2 1.6 1 0 0 1 1 1 1 Coiled-coil domain of unknown function Tropomyosin_1 PF12718.2 CCF36951.1 - 0.013 15.2 1.0 0.013 15.2 0.7 2.3 1 1 1 2 2 2 0 Tropomyosin like TMF_DNA_bd PF12329.3 CCF36951.1 - 0.017 14.9 4.6 0.045 13.5 1.9 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.10 CCF36951.1 - 0.017 14.6 5.6 0.017 14.6 3.9 2.2 2 1 0 2 2 2 0 Septum formation initiator DUF45 PF01863.12 CCF36951.1 - 0.03 14.1 0.9 0.062 13.0 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF45 ADIP PF11559.3 CCF36951.1 - 0.068 13.0 5.9 0.03 14.2 2.3 1.8 2 0 0 2 2 1 0 Afadin- and alpha -actinin-Binding Mnd1 PF03962.10 CCF36951.1 - 0.088 12.4 8.1 0.14 11.7 5.6 1.3 1 0 0 1 1 1 0 Mnd1 family KLRAQ PF10205.4 CCF36951.1 - 0.13 12.2 3.3 0.44 10.5 2.3 1.9 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein ERM PF00769.14 CCF36951.1 - 0.14 11.6 9.0 0.21 11.0 6.2 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family CENP-Q PF13094.1 CCF36951.1 - 0.19 11.7 7.8 0.41 10.6 5.4 1.6 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Herpes_UL6 PF01763.11 CCF36951.1 - 0.2 9.7 4.9 0.8 7.8 1.2 2.2 1 1 1 2 2 2 0 Herpesvirus UL6 like bZIP_1 PF00170.16 CCF36951.1 - 0.22 11.5 6.5 0.72 9.8 2.3 2.4 2 0 0 2 2 2 0 bZIP transcription factor DUF904 PF06005.7 CCF36951.1 - 0.24 11.6 5.2 0.59 10.4 3.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF904) V_ATPase_I PF01496.14 CCF36951.1 - 0.27 9.0 3.6 0.35 8.6 2.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SlyX PF04102.7 CCF36951.1 - 0.47 10.8 12.8 3.1 8.2 0.3 3.8 1 1 2 3 3 3 0 SlyX Sipho_Gp157 PF05565.6 CCF36951.1 - 0.48 9.9 4.9 0.78 9.2 0.3 2.4 1 1 0 2 2 2 0 Siphovirus Gp157 Prefoldin_2 PF01920.15 CCF36951.1 - 6.6 6.5 10.4 33 4.3 4.4 2.8 2 1 0 2 2 2 0 Prefoldin subunit NGP1NT PF08153.7 CCF36952.1 - 1.6e-47 160.7 0.0 2.6e-47 160.0 0.0 1.3 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.18 CCF36952.1 - 4.9e-19 68.4 0.0 7.2e-15 54.9 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 CCF36952.1 - 5.3e-05 22.5 0.1 0.00028 20.1 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 CCF36952.1 - 0.00026 20.2 0.0 0.00079 18.6 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 CCF36952.1 - 0.0013 18.1 0.0 0.24 10.8 0.0 3.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.16 CCF36952.1 - 0.0014 17.9 0.1 0.19 10.9 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family Dynamin_N PF00350.18 CCF36952.1 - 0.07 12.9 0.5 4.6 7.0 0.1 3.2 2 1 1 3 3 3 0 Dynamin family DDE_Tnp_IS66_C PF13817.1 CCF36952.1 - 0.13 12.2 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 IS66 C-terminal element GMC_oxred_N PF00732.14 CCF36953.1 - 1.3e-37 129.5 0.0 2.1e-37 128.8 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF36953.1 - 1e-05 25.8 0.0 2.1e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase FTA2 PF13095.1 CCF36953.1 - 0.045 13.3 0.3 0.074 12.6 0.2 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 zf-C2H2 PF00096.21 CCF36954.1 - 0.00051 20.2 2.9 0.0014 18.8 2.0 1.8 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF36954.1 - 0.0061 16.8 1.7 0.018 15.3 1.2 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CCF36954.1 - 0.0085 16.2 0.6 0.018 15.1 0.4 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding c-SKI_SMAD_bind PF08782.5 CCF36954.1 - 0.051 13.7 0.3 0.09 12.9 0.2 1.4 1 0 0 1 1 1 0 c-SKI Smad4 binding domain zf-met PF12874.2 CCF36954.1 - 0.069 13.3 0.5 0.14 12.4 0.4 1.5 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 CCF36954.1 - 0.071 13.0 0.7 0.18 11.7 0.5 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger Adeno_PX PF05829.7 CCF36954.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Adenovirus late L2 mu core protein (Protein X) Oxidored_q6 PF01058.17 CCF36955.1 - 1.8e-23 82.5 0.1 2.3e-23 82.2 0.1 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit DEC-1_C PF04626.8 CCF36955.1 - 0.12 12.4 0.3 0.18 11.9 0.2 1.2 1 0 0 1 1 1 0 Dec-1 protein, C terminal region Fungal_trans_2 PF11951.3 CCF36956.1 - 6.3e-06 25.0 0.2 1.4e-05 23.9 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain p450 PF00067.17 CCF36957.1 - 3.2e-48 164.4 0.0 4.2e-48 164.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Phosphonate-bd PF12974.2 CCF36957.1 - 0.077 12.3 0.1 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein ADH_zinc_N PF00107.21 CCF36958.1 - 6e-20 71.1 0.2 9.2e-20 70.5 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF36958.1 - 1.1e-11 45.7 0.1 2.2e-11 44.7 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF36958.1 - 1.8e-07 30.8 0.0 4.6e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain NAD_binding_10 PF13460.1 CCF36958.1 - 0.027 14.4 0.1 0.043 13.8 0.1 1.4 1 0 0 1 1 1 0 NADH(P)-binding DEAD PF00270.24 CCF36959.1 - 0.013 14.9 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 DEAD/DEAH box helicase EI24 PF07264.6 CCF36960.1 - 1.7e-07 30.9 3.4 1.7e-07 30.9 2.4 2.1 2 0 0 2 2 2 1 Etoposide-induced protein 2.4 (EI24) Lip_A_acyltrans PF03279.8 CCF36960.1 - 4.3 6.1 12.1 0.66 8.7 1.8 2.5 3 0 0 3 3 3 0 Bacterial lipid A biosynthesis acyltransferase AAA_12 PF13087.1 CCF36962.1 - 2.8e-40 137.8 0.0 4.4e-40 137.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 CCF36962.1 - 1.1e-25 90.5 0.0 2.7e-25 89.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CCF36962.1 - 5.5e-08 32.4 0.0 2.3e-07 30.4 0.0 2.1 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 CCF36962.1 - 1.4e-05 25.1 0.1 0.00013 21.9 0.0 2.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.1 CCF36962.1 - 4.1e-05 23.2 0.0 0.0062 16.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.4 CCF36962.1 - 0.00013 21.1 0.1 0.3 10.0 0.0 2.2 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) ResIII PF04851.10 CCF36962.1 - 0.00079 19.3 0.0 0.0015 18.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD_C_2 PF13538.1 CCF36962.1 - 0.011 15.9 0.0 0.024 14.7 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain MFS_1 PF07690.11 CCF36963.1 - 7.5e-26 90.6 62.2 2.1e-24 85.9 29.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2754 PF10953.3 CCF36963.1 - 8.4 6.5 7.4 5.1 7.2 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2754) Epimerase PF01370.16 CCF36965.1 - 2.3e-13 50.1 0.0 3.6e-13 49.4 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF36965.1 - 1.6e-10 40.1 0.0 2.1e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 CCF36965.1 - 1.1e-09 38.6 0.6 4.2e-09 36.6 0.4 1.9 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 CCF36965.1 - 3.1e-08 32.8 0.0 7.3e-05 21.8 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.8 CCF36965.1 - 0.003 16.8 0.0 0.0044 16.2 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.20 CCF36965.1 - 0.13 12.1 4.8 0.051 13.4 0.4 2.4 2 1 0 2 2 2 0 short chain dehydrogenase bZIP_2 PF07716.10 CCF36968.1 - 7.4e-06 25.6 18.0 2.4e-05 24.0 12.5 2.0 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.16 CCF36968.1 - 0.0003 20.6 15.7 0.00061 19.6 10.9 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.12 CCF36968.1 - 0.0045 17.2 11.3 0.011 15.9 7.9 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor TPR_11 PF13414.1 CCF36969.1 - 1.6e-10 40.4 7.4 2.2e-05 23.9 0.4 2.4 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 CCF36969.1 - 3.7e-08 32.6 8.7 6.7e-07 28.7 1.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 CCF36969.1 - 6.4e-08 31.8 8.9 6e-05 22.4 1.1 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 CCF36969.1 - 7.6e-06 25.7 7.6 1.3e-05 25.0 3.3 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 CCF36969.1 - 0.00091 18.8 1.2 0.00091 18.8 0.9 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 CCF36969.1 - 0.013 15.8 4.1 0.021 15.2 1.4 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 CCF36969.1 - 0.03 15.0 10.3 0.066 13.9 0.7 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.7 CCF36969.1 - 0.077 12.8 1.8 0.14 11.9 1.2 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.1 CCF36969.1 - 0.11 13.2 4.0 0.14 12.8 0.1 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 CCF36969.1 - 0.48 10.3 2.8 0.62 9.9 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Aldo_ket_red PF00248.16 CCF36970.1 - 1.8e-66 223.8 0.0 2.3e-66 223.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family zf-HC5HC2H_2 PF13832.1 CCF36971.1 - 2e-34 117.8 7.9 2e-34 117.8 5.5 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 CCF36971.1 - 3.7e-27 94.2 7.6 3.7e-27 94.2 5.2 2.8 3 0 0 3 3 3 1 PHD-like zinc-binding domain EPL1 PF10513.4 CCF36971.1 - 1.1e-19 71.3 0.4 4.1e-19 69.3 0.3 2.1 1 0 0 1 1 1 1 Enhancer of polycomb-like PHD_2 PF13831.1 CCF36971.1 - 2.9e-14 52.0 2.1 2.9e-14 52.0 1.4 2.5 2 0 0 2 2 2 1 PHD-finger PHD PF00628.24 CCF36971.1 - 2.8e-09 36.5 23.3 8.9e-08 31.7 6.7 2.7 2 0 0 2 2 2 2 PHD-finger zf-RING-like PF08746.6 CCF36971.1 - 0.011 15.6 6.0 0.011 15.6 4.2 2.8 2 0 0 2 2 2 0 RING-like domain zf-PHD-like PF15446.1 CCF36971.1 - 9.5 5.4 15.2 0.042 13.1 2.0 2.4 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain DUF3314 PF11771.3 CCF36973.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3314) SH3_1 PF00018.23 CCF36976.1 - 4.8e-09 35.4 0.0 7.8e-09 34.7 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 CCF36976.1 - 6.4e-09 35.2 0.1 1.6e-08 34.0 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 CCF36976.1 - 6.3e-06 25.5 0.0 3.2e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain DUF3112 PF11309.3 CCF36977.1 - 2e-27 95.9 7.4 2.1e-26 92.6 0.4 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3112) Fumarate_red_C PF02300.12 CCF36977.1 - 6 6.7 7.3 1.1 9.1 0.3 2.5 1 1 1 2 2 2 0 Fumarate reductase subunit C CrtC PF07143.6 CCF36978.1 - 5.4e-16 58.7 0.0 6.4e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 Hydroxyneurosporene synthase (CrtC) WD40 PF00400.27 CCF36979.1 - 3.7e-53 175.6 16.8 4.2e-10 39.1 0.1 6.6 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.3 CCF36979.1 - 1.1e-05 23.8 4.7 0.0061 14.7 0.0 3.1 2 2 2 4 4 4 2 Nucleoporin Nup120/160 eIF2A PF08662.6 CCF36979.1 - 1.7e-05 24.6 1.0 0.00029 20.6 0.0 2.6 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A FAD_binding_9 PF08021.6 CCF36979.1 - 0.016 15.1 0.1 0.92 9.4 0.0 2.5 2 0 0 2 2 2 0 Siderophore-interacting FAD-binding domain DinB PF05163.7 CCF36979.1 - 0.048 13.3 0.3 0.083 12.6 0.2 1.3 1 0 0 1 1 1 0 DinB family NAD_binding_8 PF13450.1 CCF36980.1 - 3.8e-06 26.8 0.0 5.9e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 CCF36980.1 - 0.00015 20.9 0.0 0.0002 20.5 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase HI0933_like PF03486.9 CCF36980.1 - 0.16 10.3 0.0 0.21 10.0 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein adh_short PF00106.20 CCF36981.1 - 7.8e-09 35.6 0.3 1.2e-08 35.0 0.2 1.4 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.8 CCF36981.1 - 8.4e-06 25.2 1.0 8.4e-06 25.2 0.7 1.7 2 0 0 2 2 2 1 NmrA-like family KR PF08659.5 CCF36981.1 - 1.4e-05 24.8 0.4 2.6e-05 23.9 0.2 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF36981.1 - 2e-05 24.6 4.0 2.9e-05 24.1 0.5 2.2 2 1 0 2 2 2 1 NADH(P)-binding adh_short_C2 PF13561.1 CCF36981.1 - 0.00058 19.7 0.0 0.00064 19.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 CCF36981.1 - 0.0015 17.9 0.1 0.0024 17.3 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.15 CCF36981.1 - 0.013 15.3 1.8 0.22 11.4 0.5 2.1 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus F420_oxidored PF03807.12 CCF36981.1 - 0.028 14.8 0.2 0.054 13.9 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Eno-Rase_NADH_b PF12242.3 CCF36981.1 - 0.038 13.7 0.9 0.038 13.7 0.7 1.8 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase 3Beta_HSD PF01073.14 CCF36981.1 - 0.082 11.5 0.2 0.13 10.9 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.13 CCF36981.1 - 0.13 12.2 1.2 0.34 10.9 0.2 2.1 2 1 0 2 2 2 0 TrkA-N domain DUF2263 PF10021.4 CCF36983.1 - 3.8e-12 46.4 0.0 6.7e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Macro PF01661.16 CCF36983.1 - 0.001 18.9 0.0 0.017 14.9 0.0 2.2 2 0 0 2 2 2 1 Macro domain Nucleoplasmin PF03066.10 CCF36983.1 - 4.6 6.7 16.1 0.51 9.8 3.9 2.5 2 0 0 2 2 2 0 Nucleoplasmin EcKinase PF02958.15 CCF36984.1 - 3.8e-19 68.9 0.0 9.1e-19 67.6 0.0 1.5 1 1 0 1 1 1 1 Ecdysteroid kinase APH PF01636.18 CCF36984.1 - 1.2e-10 41.5 0.4 1.1e-08 35.1 0.0 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CCF36984.1 - 0.00091 18.8 0.0 0.0016 18.0 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.6 CCF36984.1 - 0.19 10.3 0.0 0.35 9.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Peptidase_M20 PF01546.23 CCF36985.1 - 1.7e-19 70.0 0.5 2.5e-19 69.5 0.4 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 CCF36985.1 - 3.7e-13 49.1 0.1 7.9e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Spatacsin_C PF14649.1 CCF36985.1 - 0.09 11.6 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Spatacsin C-terminus Gln-synt_C PF00120.19 CCF36987.1 - 4e-65 219.5 0.0 5e-65 219.2 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain FA_hydroxylase PF04116.8 CCF36988.1 - 8.5e-16 58.3 18.7 8.5e-16 58.3 13.0 2.1 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily zf-primase PF09329.6 CCF36989.1 - 0.13 11.8 2.9 0.69 9.5 2.0 2.0 1 1 0 1 1 1 0 Primase zinc finger PAT1 PF09770.4 CCF36989.1 - 5.2 5.1 10.4 6 4.9 7.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PAN_1 PF00024.21 CCF36990.1 - 0.064 13.0 0.0 0.15 11.8 0.0 1.6 1 1 0 1 1 1 0 PAN domain Pyr_redox_2 PF07992.9 CCF36993.1 - 5.5e-29 101.4 0.3 7.4e-29 101.0 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF36993.1 - 4.1e-18 65.5 2.7 3.4e-16 59.4 0.3 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF36993.1 - 5.2e-12 46.2 0.1 1.6e-07 31.5 0.0 3.1 2 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF36993.1 - 3.6e-07 29.4 2.3 0.35 9.7 0.2 3.4 3 1 0 3 3 3 3 FAD dependent oxidoreductase NAD_binding_7 PF13241.1 CCF36993.1 - 2.2e-06 27.8 0.2 0.00024 21.2 0.0 2.5 2 1 0 2 2 2 1 Putative NAD(P)-binding Thi4 PF01946.12 CCF36993.1 - 2.5e-05 23.5 0.1 0.00069 18.7 0.0 2.4 2 0 0 2 2 2 1 Thi4 family K_oxygenase PF13434.1 CCF36993.1 - 3.7e-05 22.8 0.0 0.0015 17.5 0.0 2.7 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 CCF36993.1 - 0.00014 21.7 1.0 0.026 14.5 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.15 CCF36993.1 - 0.0003 20.9 0.4 0.23 11.5 0.0 2.4 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase GIDA PF01134.17 CCF36993.1 - 0.0008 18.3 4.8 0.46 9.2 0.2 3.9 3 1 0 4 4 4 2 Glucose inhibited division protein A FAD_binding_2 PF00890.19 CCF36993.1 - 0.0056 15.5 6.4 0.17 10.6 0.2 2.9 3 0 0 3 3 3 2 FAD binding domain HI0933_like PF03486.9 CCF36993.1 - 0.027 12.9 0.4 2.1 6.7 0.1 3.0 3 0 0 3 3 3 0 HI0933-like protein Trp_halogenase PF04820.9 CCF36993.1 - 0.029 13.0 0.3 0.39 9.2 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase MFS_1 PF07690.11 CCF36994.1 - 2.3e-34 118.6 37.6 1.6e-24 86.2 5.2 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF36994.1 - 7.4e-05 21.1 0.3 0.00011 20.5 0.2 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Pkinase PF00069.20 CCF36996.1 - 2.8e-24 85.6 0.0 4.4e-24 85.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF36996.1 - 1.2e-15 57.3 0.0 1.8e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Sec63 PF02889.11 CCF36997.1 - 6.2e-47 160.3 0.7 1.1e-46 159.5 0.1 1.7 2 0 0 2 2 2 1 Sec63 Brl domain DEAD PF00270.24 CCF36997.1 - 2.7e-33 114.8 0.0 6.4e-32 110.3 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF36997.1 - 6.2e-10 38.7 0.0 2.5e-09 36.8 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF36997.1 - 1.9e-09 37.6 0.0 4.4e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 CCF36997.1 - 0.00062 19.9 0.1 0.0025 17.9 0.1 2.1 1 1 0 1 1 1 1 AAA domain DUF2031 PF09592.5 CCF36998.1 - 0.02 14.0 0.7 0.033 13.3 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2031) Exonuc_VII_S PF02609.11 CCF36998.1 - 0.25 11.1 4.5 0.095 12.4 0.3 2.4 2 0 0 2 2 2 0 Exonuclease VII small subunit FMO-like PF00743.14 CCF36999.1 - 0.038 12.1 0.0 0.038 12.1 0.0 1.2 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Aldo_ket_red PF00248.16 CCF37000.1 - 1.1e-64 218.0 0.0 1.2e-64 217.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family CFEM PF05730.6 CCF37002.1 - 2.3e-14 52.9 10.7 3.8e-14 52.2 7.4 1.4 1 0 0 1 1 1 1 CFEM domain Gamma-thionin PF00304.15 CCF37002.1 - 0.0078 16.2 1.4 0.0078 16.2 1.0 1.8 2 0 0 2 2 2 1 Gamma-thionin family NESP55 PF06390.7 CCF37003.1 - 0.00024 20.5 2.2 0.00031 20.1 1.5 1.2 1 0 0 1 1 1 1 Neuroendocrine-specific golgi protein P55 (NESP55) HET PF06985.6 CCF37004.1 - 1.4e-22 80.3 4.6 1.9e-19 70.1 0.3 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) RPEL PF02755.10 CCF37005.1 - 7.9e-21 72.7 4.4 6e-10 38.1 0.4 2.5 2 0 0 2 2 2 2 RPEL repeat MCPVI PF02993.9 CCF37005.1 - 0.51 10.4 2.0 0.67 10.0 1.4 1.2 1 0 0 1 1 1 0 Minor capsid protein VI zf-DHHC PF01529.15 CCF37007.1 - 9.4e-21 73.9 2.3 9.4e-21 73.9 1.6 2.9 2 1 1 3 3 3 1 DHHC palmitoyltransferase Yip1 PF04893.12 CCF37007.1 - 0.0057 16.1 4.5 0.019 14.4 0.1 2.2 2 0 0 2 2 2 1 Yip1 domain Suf PF05843.9 CCF37007.1 - 0.078 12.6 3.3 0.11 12.1 2.3 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3682 PF12446.3 CCF37007.1 - 1.9 8.7 10.7 4 7.7 7.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) DUF4175 PF13779.1 CCF37007.1 - 3.6 5.1 12.5 4.7 4.7 8.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) TMEM237 PF15383.1 CCF37007.1 - 7.2 5.6 5.7 12 4.8 4.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 237 Amidohydro_3 PF07969.6 CCF37009.1 - 4.9e-49 167.6 0.7 5.7e-49 167.4 0.5 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 CCF37009.1 - 1.3e-10 40.9 0.0 4.8e-10 39.1 0.0 2.1 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_4 PF13147.1 CCF37009.1 - 0.081 12.9 5.7 0.37 10.7 0.1 3.3 1 1 0 2 2 2 0 Amidohydrolase Linocin_M18 PF04454.7 CCF37009.1 - 0.12 11.2 0.0 0.21 10.4 0.0 1.3 1 0 0 1 1 1 0 Encapsulating protein for peroxidase Amidohydro_1 PF01979.15 CCF37009.1 - 0.14 11.8 0.1 0.96 9.0 0.0 2.1 2 1 0 2 2 2 0 Amidohydrolase family WWbp PF10349.4 CCF37010.1 - 1.6e-13 51.5 10.7 3.5e-13 50.4 7.4 1.5 1 1 0 1 1 1 1 WW-domain ligand protein SPX PF03105.14 CCF37010.1 - 0.015 15.0 5.7 0.018 14.8 4.0 1.1 1 0 0 1 1 1 0 SPX domain Ribosomal_L50 PF10501.4 CCF37010.1 - 0.11 12.4 0.9 0.78 9.7 0.0 2.1 2 0 0 2 2 2 0 Ribosomal subunit 39S Cytadhesin_P30 PF07271.6 CCF37010.1 - 2.1 7.5 13.1 2.4 7.3 9.1 1.0 1 0 0 1 1 1 0 Cytadhesin P30/P32 DUF4175 PF13779.1 CCF37010.1 - 3.3 5.3 17.1 3.5 5.1 11.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Suf PF05843.9 CCF37010.1 - 6.9 6.3 7.4 7.9 6.1 5.1 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) UCR_hinge PF02320.11 CCF37012.1 - 1.4e-27 95.3 8.8 3.6e-27 94.0 6.1 1.7 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein CDC45 PF02724.9 CCF37012.1 - 0.31 9.0 13.0 0.32 8.9 9.0 1.0 1 0 0 1 1 1 0 CDC45-like protein Merozoite_SPAM PF07133.6 CCF37012.1 - 0.32 10.8 31.5 0.41 10.5 21.9 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) MIP-T3 PF10243.4 CCF37012.1 - 0.52 8.7 26.9 0.61 8.4 18.7 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CKAP2_C PF15297.1 CCF37012.1 - 0.6 8.8 15.3 0.71 8.6 10.6 1.1 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus Cellulose_synt PF03552.9 CCF37012.1 - 0.91 7.7 3.2 0.92 7.7 2.2 1.0 1 0 0 1 1 1 0 Cellulose synthase Mitofilin PF09731.4 CCF37012.1 - 1.2 7.7 16.6 1.3 7.6 11.5 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Daxx PF03344.10 CCF37012.1 - 1.3 7.3 30.0 1.5 7.2 20.8 1.0 1 0 0 1 1 1 0 Daxx Family DUF1510 PF07423.6 CCF37012.1 - 1.4 8.2 23.9 1.7 8.0 16.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Ycf1 PF05758.7 CCF37012.1 - 1.5 6.4 13.4 1.6 6.3 9.3 1.0 1 0 0 1 1 1 0 Ycf1 Tim54 PF11711.3 CCF37012.1 - 1.7 7.1 14.8 1.9 7.0 10.3 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Myc_N PF01056.13 CCF37012.1 - 1.8 7.6 20.1 2.9 6.9 13.9 1.4 1 0 0 1 1 1 0 Myc amino-terminal region SAPS PF04499.10 CCF37012.1 - 2.9 6.4 10.0 3.1 6.3 7.0 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Raftlin PF15250.1 CCF37012.1 - 3 6.2 8.0 3.2 6.1 5.5 1.1 1 0 0 1 1 1 0 Raftlin eIF-3c_N PF05470.7 CCF37012.1 - 3.6 5.5 11.8 3.7 5.5 8.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus CMV_1a PF12467.3 CCF37012.1 - 3.6 7.9 14.3 4.8 7.5 9.9 1.3 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family Spore_coat_CotO PF14153.1 CCF37012.1 - 4.3 6.7 21.6 5.5 6.3 15.0 1.3 1 0 0 1 1 1 0 Spore coat protein CotO DDHD PF02862.12 CCF37012.1 - 5 6.8 10.2 6.3 6.5 7.0 1.2 1 0 0 1 1 1 0 DDHD domain DDRGK PF09756.4 CCF37012.1 - 5.1 6.4 22.3 6.3 6.1 15.5 1.2 1 0 0 1 1 1 0 DDRGK domain Neur_chan_memb PF02932.11 CCF37012.1 - 5.3 6.8 5.9 6.1 6.6 4.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4045 PF13254.1 CCF37012.1 - 5.5 6.1 13.8 6 6.0 9.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF506 PF04720.7 CCF37012.1 - 5.5 6.5 7.4 6.7 6.2 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF506) SpoIIP PF07454.6 CCF37012.1 - 5.9 5.9 11.1 7 5.7 7.7 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF2413 PF10310.4 CCF37012.1 - 6.1 5.5 16.9 8.2 5.1 11.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) RRN3 PF05327.6 CCF37012.1 - 7.7 4.4 12.5 8.8 4.2 8.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF3537 PF12056.3 CCF37012.1 - 8.2 5.0 7.8 10 4.7 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) APG6 PF04111.7 CCF37012.1 - 9.7 5.1 14.5 11 5.0 10.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Zip PF02535.17 CCF37012.1 - 9.9 5.0 8.9 12 4.8 6.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Zn_clus PF00172.13 CCF37014.1 - 1e-11 44.5 12.9 1.2e-11 44.3 9.0 1.1 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2039 PF10217.4 CCF37014.1 - 0.071 13.1 5.7 0.085 12.8 4.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) Fungal_trans PF04082.13 CCF37015.1 - 9.7e-15 54.1 0.4 7.4e-14 51.2 0.1 2.2 1 1 1 2 2 2 1 Fungal specific transcription factor domain SOUL PF04832.7 CCF37015.1 - 0.016 14.7 0.0 0.059 12.9 0.0 1.9 2 0 0 2 2 2 0 SOUL heme-binding protein Intg_mem_TP0381 PF09529.5 CCF37015.1 - 0.061 12.5 0.3 0.11 11.7 0.2 1.3 1 0 0 1 1 1 0 Integral membrane protein (intg_mem_TP0381) Malate_synthase PF01274.17 CCF37016.1 - 1.1e-101 340.4 0.0 1.2e-101 340.2 0.0 1.0 1 0 0 1 1 1 1 Malate synthase APH PF01636.18 CCF37017.1 - 2.2e-32 112.6 0.0 3e-32 112.2 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 CCF37017.1 - 0.0024 17.0 0.0 0.0035 16.5 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Fructosamin_kin PF03881.9 CCF37017.1 - 0.011 14.7 0.0 0.056 12.4 0.0 1.9 1 1 0 1 1 1 0 Fructosamine kinase RIO1 PF01163.17 CCF37017.1 - 0.011 15.0 0.0 0.69 9.2 0.0 2.2 2 0 0 2 2 2 0 RIO1 family Kdo PF06293.9 CCF37017.1 - 0.036 13.1 0.0 0.44 9.5 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family CBFB_NFYA PF02045.10 CCF37018.1 - 8e-31 106.3 4.1 1.7e-30 105.3 2.9 1.6 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Hus1 PF04005.7 CCF37018.1 - 0.074 11.9 0.1 0.15 10.9 0.1 1.4 1 0 0 1 1 1 0 Hus1-like protein Ligase_CoA PF00549.14 CCF37019.1 - 1.6e-18 66.7 0.4 2.6e-18 66.0 0.3 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.1 CCF37019.1 - 8.9e-10 38.3 0.1 1.5e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding PF02629.14 CCF37019.1 - 0.0005 20.5 2.1 0.0005 20.5 1.4 2.5 4 0 0 4 4 4 1 CoA binding domain CoA_binding_2 PF13380.1 CCF37019.1 - 0.17 12.0 0.8 1.1 9.4 0.1 2.5 3 0 0 3 3 3 0 CoA binding domain Fungal_trans PF04082.13 CCF37020.1 - 1.9e-29 102.3 0.0 2.7e-29 101.8 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF37020.1 - 3.1e-05 23.8 11.0 5.6e-05 22.9 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.19 CCF37023.1 - 7.6e-75 252.2 23.1 9.2e-75 251.9 16.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF37023.1 - 5.8e-26 91.0 29.0 1.9e-20 72.9 9.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.15 CCF37023.1 - 0.0035 15.4 0.2 0.0082 14.2 0.1 1.5 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family ABC_tran PF00005.22 CCF37025.1 - 1.3e-47 161.5 0.0 3.8e-27 95.2 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 CCF37025.1 - 1e-46 159.5 34.9 1.6e-26 93.3 10.2 3.2 3 0 0 3 3 3 3 ABC transporter transmembrane region AAA_21 PF13304.1 CCF37025.1 - 4.1e-06 26.9 0.4 1.4 8.7 0.1 4.1 3 1 0 3 3 3 2 AAA domain AAA_16 PF13191.1 CCF37025.1 - 6.6e-06 26.2 0.2 0.16 11.9 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.14 CCF37025.1 - 2.7e-05 23.5 0.4 0.67 9.1 0.1 3.4 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain Miro PF08477.8 CCF37025.1 - 5.4e-05 23.6 1.4 0.12 12.8 0.1 2.7 2 0 0 2 2 2 2 Miro-like protein AAA_29 PF13555.1 CCF37025.1 - 5.7e-05 22.5 0.8 0.14 11.7 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 CCF37025.1 - 8e-05 22.5 0.4 0.19 11.6 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_17 PF13207.1 CCF37025.1 - 0.00012 22.8 0.2 0.24 12.2 0.0 3.1 3 0 0 3 3 2 1 AAA domain DUF258 PF03193.11 CCF37025.1 - 0.00021 20.5 0.9 0.093 11.9 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Zeta_toxin PF06414.7 CCF37025.1 - 0.00025 20.2 0.0 0.13 11.3 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin AAA_30 PF13604.1 CCF37025.1 - 0.00054 19.6 1.2 0.45 10.0 0.1 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 CCF37025.1 - 0.0014 18.8 0.2 1.8 8.7 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_10 PF12846.2 CCF37025.1 - 0.0017 17.8 0.5 2.4 7.5 0.0 2.9 3 0 0 3 3 3 2 AAA-like domain TrwB_AAD_bind PF10412.4 CCF37025.1 - 0.004 15.8 0.2 0.37 9.3 0.0 2.3 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain AAA_25 PF13481.1 CCF37025.1 - 0.0047 16.3 0.1 0.79 9.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.12 CCF37025.1 - 0.011 15.6 3.7 0.12 12.1 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_28 PF13521.1 CCF37025.1 - 0.013 15.5 0.4 0.062 13.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 CCF37025.1 - 0.015 15.6 5.4 0.57 10.4 0.0 2.7 3 0 0 3 3 2 0 AAA domain FtsK_SpoIIIE PF01580.13 CCF37025.1 - 0.017 14.6 0.0 4.5 6.6 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family MobB PF03205.9 CCF37025.1 - 0.018 14.7 2.0 1.3 8.7 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 CCF37025.1 - 0.031 14.5 1.0 2.1 8.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 CCF37025.1 - 0.038 13.6 0.4 0.37 10.4 0.0 2.4 2 0 0 2 2 2 0 NACHT domain T2SE PF00437.15 CCF37025.1 - 0.042 12.7 0.1 0.95 8.3 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein SRP54 PF00448.17 CCF37025.1 - 0.051 13.0 0.3 0.59 9.5 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain ArgK PF03308.11 CCF37025.1 - 0.053 12.2 1.3 0.49 9.1 0.2 2.3 2 0 0 2 2 2 0 ArgK protein Dynamin_N PF00350.18 CCF37025.1 - 0.093 12.5 3.7 0.57 9.9 0.2 2.4 2 0 0 2 2 2 0 Dynamin family ATP_bind_1 PF03029.12 CCF37025.1 - 0.17 11.3 1.8 7 6.1 0.2 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein RNA_helicase PF00910.17 CCF37025.1 - 0.18 11.9 0.0 32 4.7 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_15 PF13175.1 CCF37025.1 - 0.42 9.6 0.0 6.7 5.6 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain cobW PF02492.14 CCF37025.1 - 0.77 9.1 3.3 1.2 8.5 0.2 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.4 CCF37025.1 - 0.8 9.1 2.3 2.3 7.6 0.0 2.5 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Podoplanin PF05808.6 CCF37027.1 - 0.00014 21.4 0.0 0.00033 20.2 0.0 1.5 1 0 0 1 1 1 1 Podoplanin MtrF PF09472.5 CCF37027.1 - 0.048 12.9 1.9 0.082 12.1 1.3 1.3 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) V_ATPase_I PF01496.14 CCF37028.1 - 0.49 8.1 4.9 0.66 7.7 3.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HsdM_N PF12161.3 CCF37028.1 - 0.82 10.0 8.0 1.8 8.9 5.4 1.7 1 1 0 1 1 1 0 HsdM N-terminal domain PIN PF01850.16 CCF37028.1 - 0.89 9.8 7.2 0.093 13.0 1.1 2.1 1 1 1 2 2 2 0 PIN domain SUR7 PF06687.7 CCF37030.1 - 0.0005 19.6 3.6 0.0018 17.9 2.5 1.9 1 1 0 1 1 1 1 SUR7/PalI family UPF0182 PF03699.8 CCF37030.1 - 0.031 12.2 0.2 0.041 11.8 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) HTH_Tnp_Tc5 PF03221.11 CCF37033.1 - 3.4e-12 45.9 0.1 7.2e-12 44.9 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF37033.1 - 4.7e-12 45.2 0.2 9.1e-12 44.3 0.2 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_1 PF03184.14 CCF37033.1 - 7.7e-08 31.7 0.0 1.3e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_28 PF13518.1 CCF37033.1 - 0.00029 20.7 0.9 0.00081 19.3 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 CCF37033.1 - 0.001 18.6 0.1 0.0027 17.2 0.1 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.10 CCF37033.1 - 0.0042 16.9 0.6 0.0078 16.0 0.4 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_29 PF13551.1 CCF37033.1 - 0.0091 16.1 0.8 0.021 14.9 0.4 1.8 1 1 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_IS630 PF01710.11 CCF37033.1 - 0.01 15.5 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 0 Transposase HTH_8 PF02954.14 CCF37033.1 - 0.011 15.2 0.4 0.037 13.5 0.3 2.0 1 1 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_Tnp_1 PF01527.15 CCF37033.1 - 0.051 13.5 0.4 0.19 11.6 0.0 2.1 3 0 0 3 3 3 0 Transposase HTH_Tnp_ISL3 PF13542.1 CCF37033.1 - 0.11 11.6 0.0 0.34 10.1 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 p450 PF00067.17 CCF37034.1 - 1.9e-44 151.9 0.0 2.2e-44 151.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_4 PF01565.18 CCF37035.1 - 9.9e-19 67.1 0.7 2.7e-18 65.8 0.5 1.8 1 1 0 1 1 1 1 FAD binding domain Nrap PF03813.9 CCF37036.1 - 9.4e-236 784.7 0.0 1.1e-235 784.5 0.0 1.0 1 0 0 1 1 1 1 Nrap protein I-set PF07679.11 CCF37037.1 - 0.014 15.1 0.1 2.4 8.0 0.0 3.9 5 0 0 5 5 5 0 Immunoglobulin I-set domain PPTA PF01239.17 CCF37038.1 - 2.9e-36 121.3 22.9 2e-08 33.1 0.0 5.6 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat TPR_14 PF13428.1 CCF37038.1 - 0.022 15.3 2.7 0.08 13.6 0.6 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 CCF37038.1 - 0.053 14.2 3.0 0.49 11.1 2.0 2.6 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 CCF37038.1 - 0.14 12.5 2.6 4.5 7.6 1.4 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat GHMP_kinases_N PF00288.21 CCF37040.1 - 6.5e-21 74.1 0.0 1.7e-20 72.8 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 CCF37040.1 - 1.3e-08 34.8 0.0 2.9e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.4 CCF37040.1 - 0.008 15.4 0.0 0.019 14.2 0.0 1.6 1 0 0 1 1 1 1 Galactokinase galactose-binding signature HATPase_c PF02518.21 CCF37041.1 - 9.5e-20 70.3 0.0 1.5e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 CCF37041.1 - 1.1e-19 70.5 0.0 1e-18 67.3 0.0 2.2 2 0 0 2 2 2 1 Response regulator receiver domain Pro_isomerase PF00160.16 CCF37042.1 - 1.2e-47 161.9 1.6 1.4e-47 161.7 1.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ribosomal_S13 PF00416.17 CCF37043.1 - 1.6e-21 76.7 0.0 2e-21 76.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 Peptidase_M19 PF01244.16 CCF37044.1 - 1.2e-100 336.5 0.0 1.4e-100 336.3 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) FCH PF00611.18 CCF37045.1 - 6.2e-17 61.5 0.2 5e-16 58.6 0.0 2.7 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain RhoGAP PF00620.22 CCF37045.1 - 6.3e-17 61.5 0.2 2.1e-16 59.8 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain DEP PF00610.16 CCF37045.1 - 1.8e-13 49.9 0.0 3.9e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Med4 PF10018.4 CCF37045.1 - 0.0063 15.9 1.6 0.052 12.9 0.0 2.7 2 0 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 DUF3993 PF13158.1 CCF37045.1 - 0.066 13.0 0.3 0.26 11.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3993) MRC1 PF09444.5 CCF37045.1 - 2 8.7 6.3 0.29 11.4 1.3 1.9 2 0 0 2 2 2 0 MRC1-like domain Adaptin_N PF01602.15 CCF37046.1 - 1.8e-65 221.2 0.0 3e-65 220.5 0.0 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 CCF37046.1 - 0.17 11.7 0.2 9 6.0 0.0 2.3 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 CFEM PF05730.6 CCF37047.1 - 7e-08 32.1 5.6 1.1e-07 31.5 3.9 1.3 1 0 0 1 1 1 1 CFEM domain Phage_holin_6 PF10746.4 CCF37047.1 - 4.1 7.2 8.8 0.13 12.0 0.8 2.4 3 0 0 3 3 3 0 Phage holin family 6 Condensation PF00668.15 CCF37048.1 - 0.00097 18.0 0.0 0.0036 16.1 0.0 1.8 2 0 0 2 2 2 1 Condensation domain Skp1 PF01466.14 CCF37050.1 - 2.4e-35 120.3 0.3 2.6e-35 120.2 0.2 1.0 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Myb_DNA-binding PF00249.26 CCF37050.1 - 0.13 12.2 0.4 19 5.3 0.0 2.1 2 0 0 2 2 2 0 Myb-like DNA-binding domain Ribosomal_L39 PF00832.15 CCF37051.1 - 2.8e-23 81.0 8.2 3.3e-23 80.8 5.7 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein Selenoprotein_S PF06936.6 CCF37051.1 - 0.13 11.7 0.9 0.14 11.6 0.6 1.0 1 0 0 1 1 1 0 Selenoprotein S (SelS) Ribosomal_L13e PF01294.13 CCF37051.1 - 0.13 11.6 1.8 0.14 11.6 1.2 1.0 1 0 0 1 1 1 0 Ribosomal protein L13e Arf PF00025.16 CCF37052.1 - 9.4e-74 246.3 0.0 1.1e-73 246.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 CCF37052.1 - 1.2e-13 50.6 0.0 1.5e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 CCF37052.1 - 5.3e-12 45.1 0.7 5.5e-08 31.9 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.17 CCF37052.1 - 2.8e-11 43.0 0.0 3.4e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.7 CCF37052.1 - 8.3e-09 34.9 0.0 9.9e-09 34.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 CCF37052.1 - 1.2e-08 35.4 0.0 1.7e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 CCF37052.1 - 2.9e-06 27.2 0.0 4.3e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CCF37052.1 - 1.9e-05 24.1 0.0 0.0028 17.1 0.0 2.1 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 CCF37052.1 - 0.012 14.9 0.8 0.066 12.4 0.6 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B DUF3986 PF13143.1 CCF37052.1 - 0.092 13.2 0.2 0.25 11.7 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3986) eIF-3_zeta PF05091.7 CCF37054.1 - 1.7e-11 43.4 0.0 1.7e-11 43.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) HTH_29 PF13551.1 CCF37055.1 - 1.4e-05 25.2 0.0 2.3e-05 24.4 0.0 1.4 1 1 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 CCF37055.1 - 0.00017 21.1 0.0 0.00021 20.8 0.0 1.2 1 0 0 1 1 1 1 Homeodomain-like domain GerE PF00196.14 CCF37055.1 - 0.0083 15.4 0.0 0.01 15.1 0.0 1.2 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.7 CCF37055.1 - 0.011 15.1 0.1 0.016 14.6 0.1 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_10 PF04967.7 CCF37055.1 - 0.027 14.0 0.0 0.06 12.9 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain HTH_28 PF13518.1 CCF37055.1 - 0.03 14.3 0.3 0.06 13.3 0.2 1.6 1 1 0 1 1 1 0 Helix-turn-helix domain TrmB PF01978.14 CCF37055.1 - 0.095 12.4 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF2267 PF10025.4 CCF37055.1 - 0.12 12.4 0.1 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) MMS1_N PF10433.4 CCF37057.1 - 7.3e-84 281.7 0.0 1.2e-83 281.0 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Rad21_Rec8_N PF04825.8 CCF37058.1 - 4.8e-37 126.3 0.0 9e-37 125.4 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.11 CCF37058.1 - 9.9e-09 34.2 0.0 2.1e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein ScpA_ScpB PF02616.9 CCF37058.1 - 0.0011 18.6 1.0 0.054 13.0 0.0 2.6 3 0 0 3 3 3 1 ScpA/B protein HSP20 PF00011.16 CCF37059.1 - 4.7e-10 39.2 0.0 6e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Glyco_hydro_61 PF03443.9 CCF37060.1 - 7.6e-44 150.1 0.1 9.1e-44 149.8 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DUF1593 PF07632.6 CCF37061.1 - 1.1e-98 329.6 0.0 1.4e-98 329.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) Root_cap PF06830.6 CCF37061.1 - 0.13 12.0 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 Root cap REJ PF02010.10 CCF37061.1 - 0.18 10.0 0.0 0.25 9.6 0.0 1.2 1 0 0 1 1 1 0 REJ domain TLD PF07534.11 CCF37062.1 - 4.3e-25 88.3 0.0 3.1e-13 49.9 0.0 2.4 2 0 0 2 2 2 2 TLD Pkinase PF00069.20 CCF37063.1 - 3.2e-74 249.3 0.0 4.4e-74 248.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF37063.1 - 1e-31 109.9 0.0 1.3e-31 109.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF37063.1 - 0.00055 18.9 0.0 0.0011 18.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 CCF37063.1 - 0.002 17.2 0.1 0.0033 16.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CCF37063.1 - 0.0099 15.6 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 CCF37063.1 - 0.048 12.4 0.0 0.074 11.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Gag_p6 PF08705.6 CCF37063.1 - 0.085 12.9 0.1 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Gag protein p6 S_100 PF01023.14 CCF37063.1 - 0.1 11.9 0.3 0.36 10.2 0.2 1.9 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain SDA1 PF05285.7 CCF37067.1 - 6.8e-90 301.6 33.6 6.8e-90 301.6 23.3 2.4 3 0 0 3 3 3 2 SDA1 NUC130_3NT PF08158.7 CCF37067.1 - 8.4e-17 61.2 0.2 2e-16 60.0 0.2 1.7 1 0 0 1 1 1 1 NUC130/3NT domain FhuF_C PF11575.3 CCF37068.1 - 0.0046 16.5 0.4 0.0046 16.5 0.2 3.9 5 0 0 5 5 5 1 FhuF 2Fe-2S C-terminal domain YhfH PF14149.1 CCF37068.1 - 0.051 13.3 1.1 0.051 13.3 0.7 4.0 5 0 0 5 5 5 0 YhfH-like protein FAD_binding_3 PF01494.14 CCF37069.1 - 3.9e-12 45.8 0.3 6.6e-12 45.1 0.1 1.4 1 1 0 1 1 1 1 FAD binding domain Tir_receptor_C PF07489.6 CCF37069.1 - 0.081 12.6 4.8 0.12 12.0 3.3 1.3 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus DUF3439 PF11921.3 CCF37069.1 - 0.34 10.6 11.9 0.66 9.7 8.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.7 CCF37069.1 - 0.61 7.7 5.4 0.79 7.4 3.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.6 CCF37069.1 - 0.7 7.8 18.5 0.98 7.3 12.8 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Mucin PF01456.12 CCF37069.1 - 2 8.2 20.6 0.44 10.3 12.0 1.5 2 0 0 2 2 2 0 Mucin-like glycoprotein CAP PF00188.21 CCF37070.1 - 5.5e-21 75.3 0.3 6.8e-21 75.0 0.2 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Peptidase_C2 PF00648.16 CCF37071.1 - 9.9e-05 21.4 0.0 9.9e-05 21.4 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease Peptidase_C1 PF00112.18 CCF37071.1 - 0.022 14.6 0.1 0.024 14.5 0.1 1.1 1 0 0 1 1 1 0 Papain family cysteine protease MR_MLE_C PF13378.1 CCF37072.1 - 2.5e-19 69.2 0.4 6.4e-19 67.9 0.1 1.8 1 1 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE PF01188.16 CCF37072.1 - 6.2e-13 49.0 0.4 1.4e-12 47.8 0.3 1.7 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MR_MLE_N PF02746.11 CCF37072.1 - 0.029 14.3 0.1 0.062 13.2 0.1 1.7 1 1 0 1 1 1 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Sugar_tr PF00083.19 CCF37073.1 - 8.7e-93 311.3 19.2 1e-92 311.1 13.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF37073.1 - 6.4e-40 136.9 40.1 2.8e-34 118.3 15.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF37073.1 - 2e-06 26.3 10.3 0.00017 19.9 1.5 2.2 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) FA_desaturase PF00487.19 CCF37074.1 - 1.1e-27 97.1 18.5 1.6e-27 96.5 12.8 1.2 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.3 CCF37074.1 - 6.1e-08 32.7 0.0 1.4e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) HET PF06985.6 CCF37075.1 - 5.3e-09 36.3 0.0 1.7e-08 34.7 0.0 1.9 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) SLAC1 PF03595.12 CCF37076.1 - 3.6e-84 282.2 36.2 4.1e-84 282.0 25.1 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Myc_N PF01056.13 CCF37077.1 - 0.0032 16.7 0.5 0.0032 16.7 0.4 1.1 1 0 0 1 1 1 1 Myc amino-terminal region SF-assemblin PF06705.6 CCF37077.1 - 0.022 13.9 3.8 0.025 13.7 2.6 1.0 1 0 0 1 1 1 0 SF-assemblin/beta giardin RED_C PF07807.6 CCF37077.1 - 0.026 14.7 1.6 0.028 14.6 0.7 1.4 1 1 0 1 1 1 0 RED-like protein C-terminal region DUF2524 PF10732.4 CCF37077.1 - 0.55 10.3 5.6 0.98 9.5 3.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2524) MFS_1 PF07690.11 CCF37078.1 - 8.9e-17 60.8 49.4 1.5e-09 37.0 11.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.11 CCF37079.1 - 4.1e-20 71.7 40.8 4.1e-20 71.7 28.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Ferric_reduct PF01794.14 CCF37080.1 - 9.3e-17 61.2 13.1 9.3e-17 61.2 9.1 1.9 1 1 1 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.7 CCF37080.1 - 2e-06 27.8 0.1 0.013 15.3 0.0 2.3 1 1 1 2 2 2 2 Ferric reductase NAD binding domain NAD_binding_1 PF00175.16 CCF37080.1 - 4.3e-06 27.2 0.0 9.4e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_8 PF08022.7 CCF37080.1 - 0.00028 20.7 0.1 0.00096 19.0 0.0 1.9 2 0 0 2 2 2 1 FAD-binding domain Rcd1 PF04078.8 CCF37081.1 - 3.1e-131 435.9 4.2 4.7e-131 435.3 2.9 1.2 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Pex14_N PF04695.8 CCF37081.1 - 0.021 14.8 7.2 0.033 14.2 5.0 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Herpes_UL4 PF03277.8 CCF37081.1 - 0.057 12.6 4.0 0.21 10.7 2.9 1.8 2 0 0 2 2 2 0 Herpesvirus UL4 family Maf1 PF09174.5 CCF37081.1 - 0.15 11.8 2.8 0.26 11.1 2.0 1.4 1 0 0 1 1 1 0 Maf1 regulator Band_3_cyto PF07565.8 CCF37081.1 - 0.97 8.8 7.4 0.34 10.3 3.0 1.8 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF4175 PF13779.1 CCF37081.1 - 1.1 6.8 23.1 1.5 6.4 16.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) TFIIA PF03153.8 CCF37081.1 - 1.6 8.5 21.0 2.2 8.0 14.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.5 CCF37081.1 - 2 6.5 32.2 2.3 6.2 22.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3752 PF12572.3 CCF37081.1 - 2.5 8.1 19.3 17 5.5 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3752) bZIP_C PF12498.3 CCF37081.1 - 3.7 8.8 17.6 6.7 7.9 12.2 1.4 1 0 0 1 1 1 0 Basic leucine-zipper C terminal Spt20 PF12090.3 CCF37081.1 - 5.2 6.3 10.5 11 5.3 7.3 1.5 1 0 0 1 1 1 0 Spt20 family Spore_coat_CotO PF14153.1 CCF37081.1 - 8 5.8 14.0 13 5.1 9.7 1.2 1 0 0 1 1 1 0 Spore coat protein CotO PAT1 PF09770.4 CCF37081.1 - 8.1 4.5 29.1 11 4.1 20.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 UPF0560 PF10577.4 CCF37081.1 - 8.5 4.4 17.5 11 4.1 12.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Pkinase PF00069.20 CCF37082.1 - 9.4e-61 205.2 0.0 1.4e-60 204.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF37082.1 - 6.5e-32 110.6 0.0 1e-31 110.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.14 CCF37082.1 - 2.2e-18 65.4 0.2 3.8e-18 64.6 0.1 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Kdo PF06293.9 CCF37082.1 - 6.5e-06 25.3 0.0 1.4e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 CCF37082.1 - 6.6e-05 22.0 0.0 0.0001 21.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CCF37082.1 - 0.0064 16.2 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 CCF37082.1 - 0.015 14.6 0.0 0.034 13.4 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RIO1 PF01163.17 CCF37082.1 - 0.018 14.3 1.2 0.057 12.7 0.1 2.1 2 0 0 2 2 2 0 RIO1 family Choline_kinase PF01633.15 CCF37082.1 - 0.12 11.9 0.1 0.24 10.9 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase WaaY PF06176.6 CCF37082.1 - 0.16 11.1 0.1 0.23 10.6 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) AAA_17 PF13207.1 CCF37083.1 - 1.6e-11 45.0 0.1 1.9e-11 44.8 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CCF37083.1 - 1.7e-11 44.5 0.1 3.2e-11 43.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CCF37083.1 - 6.2e-10 39.1 0.0 8.3e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain SKI PF01202.17 CCF37083.1 - 4.5e-09 36.3 0.0 5.9e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 Shikimate kinase AAA_22 PF13401.1 CCF37083.1 - 2.7e-05 24.3 0.1 4.6e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 CCF37083.1 - 6.7e-05 23.0 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 CCF37083.1 - 0.00051 19.2 0.0 0.00089 18.4 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_19 PF13245.1 CCF37083.1 - 0.00085 19.0 0.0 0.0021 17.7 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 CCF37083.1 - 0.00085 19.0 0.0 0.0016 18.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 CCF37083.1 - 0.00099 19.0 0.0 0.0013 18.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain CPT PF07931.7 CCF37083.1 - 0.0011 18.5 0.2 0.006 16.2 0.0 2.1 2 1 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_28 PF13521.1 CCF37083.1 - 0.0012 18.8 0.3 0.0017 18.3 0.2 1.6 1 1 0 1 1 1 1 AAA domain APS_kinase PF01583.15 CCF37083.1 - 0.0013 18.4 0.0 0.0021 17.7 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_16 PF13191.1 CCF37083.1 - 0.0017 18.3 0.0 0.0032 17.4 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.10 CCF37083.1 - 0.0019 17.9 0.6 0.0054 16.4 0.4 1.7 2 0 0 2 2 2 1 NTPase ABC_tran PF00005.22 CCF37083.1 - 0.0022 18.3 0.0 0.0031 17.8 0.0 1.2 1 0 0 1 1 1 1 ABC transporter T2SE PF00437.15 CCF37083.1 - 0.0037 16.2 0.1 0.006 15.5 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein RNA_helicase PF00910.17 CCF37083.1 - 0.0043 17.2 0.0 0.0061 16.7 0.0 1.2 1 0 0 1 1 1 1 RNA helicase PhoH PF02562.11 CCF37083.1 - 0.0044 16.2 0.0 0.0067 15.6 0.0 1.2 1 0 0 1 1 1 1 PhoH-like protein UPF0079 PF02367.12 CCF37083.1 - 0.0068 16.0 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 AAA_23 PF13476.1 CCF37083.1 - 0.0068 16.7 0.0 0.0094 16.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 CCF37083.1 - 0.0074 15.7 0.0 0.011 15.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 CCF37083.1 - 0.0076 15.4 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI CoaE PF01121.15 CCF37083.1 - 0.0092 15.3 0.0 0.02 14.2 0.0 1.6 2 0 0 2 2 1 1 Dephospho-CoA kinase AAA_24 PF13479.1 CCF37083.1 - 0.0093 15.5 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.10 CCF37083.1 - 0.0098 14.6 0.0 0.012 14.3 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein NB-ARC PF00931.17 CCF37083.1 - 0.013 14.3 0.0 0.02 13.7 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_29 PF13555.1 CCF37083.1 - 0.016 14.7 0.0 0.029 13.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activ_2 PF14532.1 CCF37083.1 - 0.019 15.0 0.0 0.03 14.3 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.7 CCF37083.1 - 0.024 14.2 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Arch_ATPase PF01637.13 CCF37083.1 - 0.025 14.2 0.0 0.034 13.8 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase IstB_IS21 PF01695.12 CCF37083.1 - 0.033 13.6 0.1 0.055 12.8 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Sigma54_activat PF00158.21 CCF37083.1 - 0.034 13.6 0.0 0.07 12.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_30 PF13604.1 CCF37083.1 - 0.036 13.6 0.0 0.059 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 CCF37083.1 - 0.042 13.0 0.0 0.058 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF258 cobW PF02492.14 CCF37083.1 - 0.047 13.1 0.0 0.069 12.5 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.9 CCF37083.1 - 0.047 13.3 0.0 0.078 12.6 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B KaiC PF06745.8 CCF37083.1 - 0.052 12.6 0.0 0.085 11.9 0.0 1.2 1 0 0 1 1 1 0 KaiC DUF2075 PF09848.4 CCF37083.1 - 0.052 12.5 0.0 0.065 12.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TrwB_AAD_bind PF10412.4 CCF37083.1 - 0.056 12.0 0.1 0.074 11.6 0.1 1.1 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain ResIII PF04851.10 CCF37083.1 - 0.066 13.0 0.1 0.1 12.3 0.1 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_2 PF07724.9 CCF37083.1 - 0.078 12.8 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) PIF1 PF05970.9 CCF37083.1 - 0.095 11.6 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 PIF1-like helicase RuvB_N PF05496.7 CCF37083.1 - 0.11 11.5 0.1 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_PrkA PF08298.6 CCF37083.1 - 0.12 10.9 0.0 0.16 10.5 0.0 1.1 1 0 0 1 1 1 0 PrkA AAA domain Cytidylate_kin2 PF13189.1 CCF37083.1 - 0.15 11.9 0.0 0.71 9.7 0.0 1.9 2 0 0 2 2 2 0 Cytidylate kinase-like family Aldedh PF00171.17 CCF37084.1 - 2.4e-45 154.7 0.1 2.8e-45 154.5 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 CCF37084.1 - 0.17 11.1 0.0 0.25 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) Abhydrolase_6 PF12697.2 CCF37085.1 - 0.0005 20.0 0.0 0.00056 19.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Methyltransf_23 PF13489.1 CCF37086.1 - 2.3e-19 69.6 0.0 3.5e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF37086.1 - 1.7e-08 35.0 0.0 1e-07 32.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF37086.1 - 6e-08 32.4 0.0 3.4e-07 29.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF37086.1 - 1.5e-07 31.8 0.0 3.8e-07 30.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF37086.1 - 5.6e-06 26.7 0.0 2e-05 24.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF37086.1 - 0.00012 22.4 0.0 0.00022 21.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF37086.1 - 0.0048 16.9 0.0 0.014 15.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF37086.1 - 0.013 14.8 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.13 CCF37086.1 - 0.019 14.0 0.0 0.98 8.4 0.0 2.2 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 CCF37086.1 - 0.031 13.3 0.0 0.054 12.5 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase FtsJ PF01728.14 CCF37086.1 - 0.098 12.6 0.0 0.17 11.8 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_2 PF00891.13 CCF37086.1 - 0.13 11.4 0.0 0.28 10.3 0.0 1.5 1 0 0 1 1 1 0 O-methyltransferase zf-MYND PF01753.13 CCF37088.1 - 6.8e-11 41.8 13.9 1e-10 41.3 9.6 1.3 1 0 0 1 1 1 1 MYND finger LSM PF01423.17 CCF37089.1 - 8.4e-17 60.4 0.0 1.2e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 LSM domain Ribosomal_L5 PF00281.14 CCF37090.1 - 1.6e-19 69.3 0.0 2.2e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L5 DUF2454 PF10521.4 CCF37091.1 - 2.4e-50 171.1 0.2 3.9e-50 170.4 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2454) Syja_N PF02383.13 CCF37092.1 - 2.9e-90 302.2 0.0 6.6e-90 301.0 0.0 1.6 2 0 0 2 2 2 1 SacI homology domain DBR1 PF05011.8 CCF37093.1 - 5.4e-37 126.8 0.0 1.3e-36 125.6 0.0 1.6 2 0 0 2 2 2 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.23 CCF37093.1 - 3.9e-06 26.4 0.2 8.1e-06 25.3 0.1 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Nop14 PF04147.7 CCF37093.1 - 0.67 7.7 3.5 0.83 7.4 2.4 1.0 1 0 0 1 1 1 0 Nop14-like family ERF PF04404.7 CCF37093.1 - 0.84 9.1 3.3 1.5 8.3 2.3 1.3 1 0 0 1 1 1 0 ERF superfamily Abhydrolase_6 PF12697.2 CCF37094.1 - 6.7e-27 94.8 5.7 1.8e-26 93.4 3.9 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF37094.1 - 1.2e-16 60.7 0.3 2.3e-16 59.8 0.2 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CCF37094.1 - 1e-07 31.6 0.0 3.1e-07 30.1 0.0 1.9 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_1 PF00561.15 CCF37094.1 - 1.1e-06 28.4 0.2 1.7e-06 27.8 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.15 CCF37094.1 - 1.2e-06 28.8 0.8 2.7e-06 27.8 0.5 1.4 1 1 0 1 1 1 1 Thioesterase domain Peptidase_S9 PF00326.16 CCF37094.1 - 0.00021 20.5 0.7 0.0022 17.2 0.2 2.4 3 0 0 3 3 3 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.8 CCF37094.1 - 0.00023 20.7 0.4 0.00052 19.6 0.3 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.8 CCF37094.1 - 0.001 18.6 0.2 0.0047 16.5 0.2 2.0 1 1 0 1 1 1 1 PGAP1-like protein Lipase_2 PF01674.13 CCF37094.1 - 0.0016 17.8 0.0 0.0023 17.2 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 2) Eno-Rase_NADH_b PF12242.3 CCF37094.1 - 0.0071 16.1 1.2 0.023 14.4 0.1 2.1 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Lipase_3 PF01764.20 CCF37094.1 - 0.028 14.0 0.1 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) AXE1 PF05448.7 CCF37094.1 - 0.053 12.0 0.4 1.4 7.3 0.0 2.6 2 1 1 3 3 3 0 Acetyl xylan esterase (AXE1) DUF1100 PF06500.6 CCF37094.1 - 0.07 11.6 0.0 0.095 11.2 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1100) DUF2974 PF11187.3 CCF37094.1 - 0.12 11.7 0.5 0.29 10.4 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) DUF2305 PF10230.4 CCF37094.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) DUF3530 PF12048.3 CCF37094.1 - 0.2 10.6 0.0 0.25 10.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) LSM PF01423.17 CCF37095.1 - 1.2e-18 66.3 0.1 1.6e-18 66.0 0.1 1.1 1 0 0 1 1 1 1 LSM domain PRMT5 PF05185.11 CCF37096.1 - 4.6e-23 81.8 2.2 5.3e-23 81.6 1.5 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase AA_permease_2 PF13520.1 CCF37097.1 - 4.9e-60 203.2 34.4 6.3e-57 193.0 16.5 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.16 CCF37097.1 - 8.9e-20 70.4 18.3 8.9e-20 70.4 12.7 1.6 2 0 0 2 2 2 1 Amino acid permease Aa_trans PF01490.13 CCF37097.1 - 0.00037 19.0 11.0 0.0019 16.7 7.6 2.0 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Bradykinin PF06753.7 CCF37099.1 - 7.6 6.1 6.9 0.28 10.7 0.6 1.7 2 0 0 2 2 2 0 Bradykinin Sugar_tr PF00083.19 CCF37101.1 - 5.2e-10 38.4 2.3 6.6e-10 38.1 1.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF37101.1 - 9.5e-09 34.4 8.1 9.5e-09 34.4 5.6 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Polysacc_synt_3 PF13440.1 CCF37101.1 - 0.0048 16.3 8.2 0.037 13.5 4.0 2.2 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Whirly PF08536.6 CCF37103.1 - 0.15 11.4 0.1 0.23 10.9 0.1 1.2 1 0 0 1 1 1 0 Whirly transcription factor DUF1237 PF06824.6 CCF37105.1 - 3.4e-172 572.8 0.0 3.9e-172 572.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1237) zf-C3HC4_3 PF13920.1 CCF37106.1 - 0.0014 18.2 11.7 0.0021 17.6 8.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 CCF37106.1 - 0.11 12.2 7.5 0.18 11.6 5.2 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_5 PF14634.1 CCF37106.1 - 1.9 8.2 12.7 3.1 7.5 8.8 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CCF37106.1 - 2.1 8.4 13.4 3.3 7.7 9.3 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Ras PF00071.17 CCF37107.1 - 7.7e-58 194.4 0.0 9.3e-58 194.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF37107.1 - 3.3e-20 72.7 0.0 5.3e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CCF37107.1 - 2e-14 53.1 0.0 3.6e-14 52.3 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CCF37107.1 - 1.1e-06 27.9 0.0 1.4e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 CCF37107.1 - 2.4e-06 27.1 0.0 5.9e-06 25.8 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CCF37107.1 - 0.00012 22.0 0.0 0.0002 21.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 CCF37107.1 - 0.0074 16.2 0.0 0.021 14.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CCF37107.1 - 0.053 13.6 0.0 0.22 11.6 0.0 2.0 2 1 0 2 2 2 0 AAA domain Ribosomal_S7 PF00177.16 CCF37107.1 - 0.14 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S7p/S5e Dynamin_N PF00350.18 CCF37109.1 - 2.3e-33 115.3 0.1 4e-33 114.6 0.1 1.4 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 CCF37109.1 - 9.4e-15 54.1 0.0 2.7e-14 52.6 0.0 1.7 2 0 0 2 2 2 1 Dynamin central region GED PF02212.13 CCF37109.1 - 1.2e-05 25.0 0.2 4e-05 23.4 0.2 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 CCF37109.1 - 0.0007 19.5 0.2 0.0046 16.9 0.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CCF37109.1 - 0.0016 18.9 0.0 0.0038 17.6 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein FeoB_N PF02421.13 CCF37109.1 - 0.056 12.7 0.1 3.9 6.7 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B AIG1 PF04548.11 CCF37109.1 - 0.061 12.4 0.1 3.2 6.8 0.1 2.4 2 0 0 2 2 2 0 AIG1 family LMBR1 PF04791.11 CCF37110.1 - 6.7e-18 64.5 5.5 6.7e-18 64.5 3.8 1.7 1 1 1 2 2 2 2 LMBR1-like membrane protein Dispanin PF04505.7 CCF37110.1 - 0.63 9.6 0.0 0.63 9.6 0.0 3.3 5 0 0 5 5 5 0 Interferon-induced transmembrane protein DUF4149 PF13664.1 CCF37110.1 - 5.4 7.1 20.0 0.044 13.8 2.9 3.6 4 1 0 4 4 4 0 Domain of unknown function (DUF4149) Fungal_trans PF04082.13 CCF37113.1 - 1.5e-06 27.2 0.1 2.5e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sigma70_ner PF04546.8 CCF37113.1 - 0.085 12.4 1.0 0.12 11.9 0.7 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region Zn_clus PF00172.13 CCF37114.1 - 8.9e-09 35.1 7.8 1.8e-08 34.1 5.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Trypan_PARP PF05887.6 CCF37114.1 - 3e-05 23.8 16.5 3e-05 23.8 11.4 2.9 3 0 0 3 3 3 1 Procyclic acidic repetitive protein (PARP) DUF2235 PF09994.4 CCF37115.1 - 8.3e-67 225.4 0.0 1.4e-66 224.7 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Zn_clus PF00172.13 CCF37116.1 - 1.7e-08 34.1 5.7 2.8e-08 33.5 3.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SSXRD PF09514.5 CCF37116.1 - 0.26 10.6 3.9 2.8 7.3 0.3 2.3 2 0 0 2 2 2 0 SSXRD motif DNA_methylase PF00145.12 CCF37118.1 - 0.14 11.2 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase PhoD PF09423.5 CCF37119.1 - 4e-60 203.6 0.0 4.9e-60 203.3 0.0 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase EMP24_GP25L PF01105.19 CCF37120.1 - 1.1e-45 155.6 1.2 1.3e-45 155.3 0.8 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Pox_A_type_inc PF04508.7 CCF37121.1 - 7.7 6.5 11.7 3 7.8 0.3 4.2 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat COX5A PF02284.11 CCF37122.1 - 9.3e-40 134.9 0.5 1.3e-39 134.4 0.3 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va GTP_EFTU PF00009.22 CCF37123.1 - 8.3e-22 77.5 0.0 1.4e-21 76.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 CCF37123.1 - 2e-14 53.5 0.0 4.9e-14 52.2 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 CCF37123.1 - 7.8e-11 41.9 0.8 9.4e-10 38.4 0.4 2.5 2 0 0 2 2 2 1 Elongation factor Tu domain 2 PduV-EutP PF10662.4 CCF37123.1 - 0.00051 19.5 0.4 0.29 10.5 0.1 3.3 2 1 1 3 3 3 1 Ethanolamine utilisation - propanediol utilisation Miro PF08477.8 CCF37123.1 - 0.00076 19.9 0.1 0.014 15.9 0.1 2.8 2 1 0 2 2 2 1 Miro-like protein MMR_HSR1 PF01926.18 CCF37123.1 - 0.0019 18.1 0.0 0.004 17.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.1 CCF37123.1 - 0.024 14.2 0.4 0.15 11.7 0.3 2.4 1 1 0 1 1 1 0 Elongation factor Tu domain 4 Dynamin_N PF00350.18 CCF37123.1 - 0.047 13.4 0.1 0.099 12.4 0.0 1.5 1 0 0 1 1 1 0 Dynamin family Hexapep PF00132.19 CCF37124.1 - 7.8e-10 37.8 1.4 1e-05 24.7 0.1 2.7 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 CCF37124.1 - 0.0024 17.3 8.2 0.038 13.5 0.2 3.7 2 2 1 3 3 3 2 Hexapeptide repeat of succinyl-transferase Ifi-6-16 PF06140.8 CCF37125.1 - 3.1e-07 30.0 3.8 9.7e-05 22.0 0.3 2.3 1 1 1 2 2 2 2 Interferon-induced 6-16 family DUF883 PF05957.8 CCF37125.1 - 0.006 16.9 0.1 0.036 14.4 0.0 2.0 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF883) Syndecan PF01034.15 CCF37129.1 - 0.026 14.1 0.0 0.062 12.9 0.0 1.5 1 0 0 1 1 1 0 Syndecan domain He_PIG PF05345.7 CCF37130.1 - 1.3e-14 53.8 11.0 0.00014 21.7 0.1 4.9 4 0 0 4 4 4 3 Putative Ig domain DUF4448 PF14610.1 CCF37130.1 - 9.6e-05 21.9 0.0 0.00022 20.7 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF4448) TMEM154 PF15102.1 CCF37130.1 - 0.00026 20.7 0.1 0.00026 20.7 0.0 1.8 2 0 0 2 2 2 1 TMEM154 protein family Herpes_gE PF02480.11 CCF37130.1 - 0.0069 14.6 0.0 0.011 14.0 0.0 1.2 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E RCR PF12273.3 CCF37130.1 - 0.02 15.4 0.0 0.053 14.0 0.0 1.7 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red SIT PF15330.1 CCF37130.1 - 0.037 14.1 0.0 0.12 12.4 0.0 1.9 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT BatD PF13584.1 CCF37130.1 - 0.047 12.2 0.0 0.076 11.6 0.0 1.2 1 0 0 1 1 1 0 Oxygen tolerance Ly49 PF08391.5 CCF37130.1 - 0.17 12.0 0.1 0.34 11.0 0.0 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Methyltransf_16 PF10294.4 CCF37131.1 - 2.1e-41 141.2 0.0 9.5e-41 139.1 0.0 1.8 1 1 0 1 1 1 1 Putative methyltransferase PCEMA1 PF07418.6 CCF37132.1 - 0.29 10.4 9.3 0.014 14.8 2.4 1.6 2 0 0 2 2 2 0 Acidic phosphoprotein precursor PCEMA1 KH_1 PF00013.24 CCF37133.1 - 1.3e-08 34.3 0.0 2.2e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 CCF37133.1 - 5.7e-05 22.6 0.0 0.00014 21.3 0.0 1.6 1 0 0 1 1 1 1 KH domain DUF974 PF06159.8 CCF37134.1 - 2.5e-84 282.6 0.0 2.9e-84 282.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF974) Ank PF00023.25 CCF37135.1 - 8.7e-20 69.4 0.2 3.3e-06 26.6 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.2 CCF37135.1 - 1.3e-14 54.2 0.0 3.3e-06 27.3 0.0 2.5 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF37135.1 - 2.6e-13 50.0 0.1 5.4e-05 23.5 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF37135.1 - 1.1e-10 40.7 0.1 0.00058 19.8 0.0 3.7 3 1 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.1 CCF37135.1 - 7.2e-10 38.7 2.6 0.0021 18.2 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeats (many copies) OPT PF03169.10 CCF37136.1 - 3.3e-44 151.3 2.3 3.7e-44 151.2 1.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DAO PF01266.19 CCF37137.1 - 5.2e-48 163.7 0.0 6.1e-48 163.5 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF37137.1 - 2.5e-06 27.4 0.0 6.4e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF37137.1 - 0.00012 22.0 0.0 0.018 14.9 0.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF37137.1 - 0.0041 17.1 0.0 0.074 13.1 0.0 2.2 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 CCF37137.1 - 0.0083 15.2 0.0 0.012 14.6 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.9 CCF37137.1 - 0.014 14.0 0.0 0.77 8.3 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Thi4 PF01946.12 CCF37137.1 - 0.016 14.3 0.0 0.025 13.6 0.0 1.2 1 0 0 1 1 1 0 Thi4 family ThiF PF00899.16 CCF37137.1 - 0.022 14.5 0.0 0.058 13.2 0.0 1.7 2 0 0 2 2 2 0 ThiF family Pyr_redox PF00070.22 CCF37137.1 - 0.027 14.8 0.0 0.062 13.7 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF37137.1 - 0.056 13.2 0.0 1.8 8.3 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding Shikimate_DH PF01488.15 CCF37137.1 - 0.14 12.2 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase CBM_48 PF02922.13 CCF37139.1 - 3.3e-15 55.8 0.1 6e-15 55.0 0.0 1.5 2 0 0 2 2 2 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) AAA_2 PF07724.9 CCF37140.1 - 5.6e-32 111.0 0.0 1.3e-31 109.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 CCF37140.1 - 6.6e-13 48.9 0.0 1.2e-12 48.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 CCF37140.1 - 3.5e-09 36.4 0.0 7.2e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 CCF37140.1 - 2.1e-08 33.9 0.0 4.6e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 CCF37140.1 - 9.8e-05 22.5 0.1 0.00081 19.5 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 CCF37140.1 - 0.00015 21.6 0.0 0.00033 20.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CCF37140.1 - 0.00032 21.4 0.6 0.00093 20.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CCF37140.1 - 0.00051 20.0 0.0 0.028 14.4 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.12 CCF37140.1 - 0.0023 17.3 0.0 0.0046 16.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein MCM PF00493.18 CCF37140.1 - 0.0035 16.1 0.0 0.0083 14.9 0.0 1.5 1 0 0 1 1 1 1 MCM2/3/5 family AAA_18 PF13238.1 CCF37140.1 - 0.03 14.6 1.2 0.065 13.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 CCF37140.1 - 0.063 12.1 0.1 0.11 11.4 0.1 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.22 CCF37140.1 - 0.094 13.0 0.3 0.23 11.7 0.0 1.8 2 0 0 2 2 2 0 ABC transporter AAA_15 PF13175.1 CCF37140.1 - 0.096 11.7 0.1 0.14 11.1 0.1 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.1 CCF37140.1 - 0.14 11.7 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Mg_chelatase PF01078.16 CCF37140.1 - 0.15 11.2 0.0 1 8.4 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.1 CCF37140.1 - 0.16 11.5 0.1 0.33 10.4 0.1 1.4 1 0 0 1 1 1 0 AAA domain ResIII PF04851.10 CCF37140.1 - 0.21 11.3 1.7 0.48 10.2 0.0 2.3 2 1 0 3 3 2 0 Type III restriction enzyme, res subunit ATP-synt_ab PF00006.20 CCF37141.1 - 1.9e-55 187.6 0.1 1.7e-31 109.4 0.0 2.2 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 CCF37141.1 - 3e-25 88.8 1.2 4.7e-25 88.2 0.3 1.7 2 0 0 2 2 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 CCF37141.1 - 2.1e-24 85.4 0.4 5.6e-24 84.1 0.3 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA_25 PF13481.1 CCF37141.1 - 0.0098 15.3 0.2 0.074 12.4 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA PF00004.24 CCF37141.1 - 0.015 15.5 0.5 5.6 7.1 0.0 3.5 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 CCF37141.1 - 0.015 14.4 0.1 0.029 13.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 MobB PF03205.9 CCF37141.1 - 0.02 14.5 0.1 1.2 8.8 0.0 2.6 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B KaiC PF06745.8 CCF37141.1 - 0.03 13.4 0.2 0.057 12.5 0.1 1.5 1 0 0 1 1 1 0 KaiC NACHT PF05729.7 CCF37141.1 - 0.031 13.9 0.1 0.084 12.5 0.0 1.8 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.17 CCF37141.1 - 0.035 14.2 0.0 0.16 12.1 0.0 2.0 2 0 0 2 2 2 0 RNA helicase Arch_ATPase PF01637.13 CCF37141.1 - 0.046 13.4 0.0 0.13 11.8 0.0 1.7 2 0 0 2 2 2 0 Archaeal ATPase AAA_16 PF13191.1 CCF37141.1 - 0.055 13.4 0.3 0.32 10.9 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.17 CCF37141.1 - 0.11 11.3 0.6 0.69 8.7 0.1 2.0 2 0 0 2 2 2 0 NB-ARC domain Mus7 PF09462.5 CCF37142.1 - 9e-98 328.6 4.9 1.3e-97 328.1 3.4 1.2 1 0 0 1 1 1 1 Mus7/MMS22 family RicinB_lectin_2 PF14200.1 CCF37143.1 - 0.00083 19.6 0.3 0.0032 17.8 0.1 2.0 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like SKG6 PF08693.5 CCF37143.1 - 0.003 16.8 4.7 0.0069 15.6 3.2 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain CBM-like PF14683.1 CCF37143.1 - 0.081 12.5 0.2 0.17 11.5 0.1 1.5 1 0 0 1 1 1 0 Polysaccharide lyase family 4, domain III Ank_5 PF13857.1 CCF37144.1 - 1.1e-07 31.8 0.1 2.2e-07 30.8 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 CCF37144.1 - 0.0068 16.1 0.5 0.021 14.6 0.2 1.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.2 CCF37144.1 - 0.0092 16.2 0.0 0.016 15.5 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF37144.1 - 0.026 15.0 0.0 0.055 13.9 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF37144.1 - 0.037 14.2 0.0 0.21 11.9 0.0 2.2 3 0 0 3 3 3 0 Ankyrin repeat APG6 PF04111.7 CCF37144.1 - 9 5.2 6.6 12 4.8 4.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4407 PF14362.1 CCF37144.1 - 9.4 5.0 10.9 12 4.7 7.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BAF1_ABF1 PF04684.8 CCF37146.1 - 6.5 5.4 6.7 9.8 4.8 4.6 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor LigB PF02900.13 CCF37147.1 - 3.3e-12 45.9 0.0 5.1e-11 42.0 0.0 2.4 1 1 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Cupin_2 PF07883.6 CCF37148.1 - 4.3e-06 26.1 0.0 6.3e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.2 CCF37148.1 - 0.063 12.8 0.0 0.096 12.2 0.0 1.3 1 0 0 1 1 1 0 Cupin FAA_hydrolase PF01557.13 CCF37149.1 - 1.3e-22 80.3 0.0 1.5e-22 80.1 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family eIF2A PF08662.6 CCF37151.1 - 5.8e-79 264.3 0.0 4.5e-78 261.4 0.0 2.1 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.27 CCF37151.1 - 9.9e-05 22.0 1.9 1.2 9.1 0.2 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat CDV3 PF15359.1 CCF37151.1 - 0.0027 17.7 0.2 0.0027 17.7 0.2 3.0 3 1 0 3 3 3 1 Carnitine deficiency-associated protein 3 CIA30 PF08547.7 CCF37152.1 - 2e-43 147.9 0.0 2.6e-43 147.5 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Apc5 PF12862.2 CCF37153.1 - 6.3e-33 112.4 5.3 1.1e-32 111.7 2.1 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 5 TPR_14 PF13428.1 CCF37153.1 - 0.07 13.7 14.8 18 6.3 0.0 7.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_19 PF14559.1 CCF37153.1 - 0.3 11.4 12.9 0.27 11.5 0.2 5.1 5 1 0 5 5 5 0 Tetratricopeptide repeat DDE_1 PF03184.14 CCF37156.1 - 9.3e-53 178.5 0.0 1.3e-52 178.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 CCF37156.1 - 5.6e-13 48.4 0.1 1.7e-12 46.9 0.0 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF37156.1 - 1.4e-11 43.6 0.1 2.7e-11 42.8 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.1 CCF37156.1 - 7.8e-07 28.9 0.0 1.5e-06 28.0 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.1 CCF37156.1 - 0.0019 17.8 0.1 0.0071 15.9 0.0 2.1 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 CCF37156.1 - 0.0023 17.8 0.2 0.0076 16.2 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain CENP-B_N PF04218.8 CCF37156.1 - 0.036 13.4 0.0 0.068 12.6 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Fer4_13 PF13370.1 CCF37157.1 - 4.9 7.6 11.8 15 6.0 0.0 4.9 3 2 1 4 4 4 0 4Fe-4S single cluster domain NAD_binding_8 PF13450.1 CCF37158.1 - 1.6e-13 50.4 0.1 3e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF37158.1 - 0.0039 16.1 0.1 0.028 13.3 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 CCF37158.1 - 0.0042 16.8 0.1 0.45 10.2 0.0 3.0 2 1 1 3 3 3 1 FAD-NAD(P)-binding MFS_1 PF07690.11 CCF37160.1 - 2.8e-15 55.9 17.7 3.8e-15 55.4 12.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily BTB PF00651.26 CCF37163.1 - 0.012 15.5 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 BTB/POZ domain EF-hand_4 PF12763.2 CCF37163.1 - 0.084 12.6 0.2 12 5.7 0.0 2.2 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand Cyclin PF08613.6 CCF37164.1 - 7e-29 101.1 0.2 1.5e-28 100.1 0.0 1.7 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.18 CCF37164.1 - 0.0013 18.3 0.1 0.0019 17.7 0.1 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain zf-AN1 PF01428.11 CCF37166.1 - 3.1e-11 42.9 12.5 4.3e-11 42.4 8.7 1.2 1 0 0 1 1 1 1 AN1-like Zinc finger HhH-GPD PF00730.20 CCF37167.1 - 2.7e-17 62.9 0.0 5.5e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 CCF37167.1 - 9.3e-09 34.5 0.0 2.2e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif XFP_N PF09364.5 CCF37168.1 - 6.6e-173 574.5 0.0 8.5e-173 574.2 0.0 1.1 1 0 0 1 1 1 1 XFP N-terminal domain XFP_C PF09363.5 CCF37168.1 - 9.4e-83 276.6 0.0 1.3e-82 276.1 0.0 1.2 1 0 0 1 1 1 1 XFP C-terminal domain XFP PF03894.10 CCF37168.1 - 1.4e-81 272.3 0.0 3.4e-81 271.1 0.0 1.7 2 0 0 2 2 2 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase PALP PF00291.20 CCF37171.1 - 2.3e-30 105.9 0.0 2.9e-30 105.5 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme LYTB PF02401.13 CCF37171.1 - 0.0047 15.8 0.0 0.0072 15.2 0.0 1.3 1 0 0 1 1 1 1 LytB protein OPT PF03169.10 CCF37172.1 - 8.9e-147 490.1 49.1 1e-146 489.9 34.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein F_bP_aldolase PF01116.15 CCF37173.1 - 1.5e-12 47.2 0.0 1.6e-12 47.1 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II CobS PF02654.10 CCF37173.1 - 0.11 12.0 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Cobalamin-5-phosphate synthase ABC2_membrane PF01061.19 CCF37174.1 - 5.4e-51 172.7 35.7 4.4e-45 153.4 14.3 2.7 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.22 CCF37174.1 - 2.3e-35 121.8 0.2 3.6e-16 59.7 0.0 3.2 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.7 CCF37174.1 - 8.6e-30 102.4 0.0 2.2e-29 101.1 0.0 1.7 1 0 0 1 1 1 1 CDR ABC transporter ABC_trans_N PF14510.1 CCF37174.1 - 5.1e-10 39.3 0.2 2.3e-09 37.2 0.1 2.2 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_25 PF13481.1 CCF37174.1 - 4.9e-08 32.6 0.1 0.00092 18.6 0.0 2.9 3 0 0 3 3 3 2 AAA domain ABC2_membrane_3 PF12698.2 CCF37174.1 - 9.1e-08 31.5 4.2 9.1e-08 31.5 2.9 1.9 2 0 0 2 2 1 1 ABC-2 family transporter protein AAA_29 PF13555.1 CCF37174.1 - 4.1e-06 26.2 0.0 0.0025 17.3 0.0 2.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_17 PF13207.1 CCF37174.1 - 7.2e-06 26.8 0.0 0.0015 19.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CCF37174.1 - 7.3e-06 26.1 0.0 0.02 15.0 0.0 3.1 2 1 0 2 2 2 2 AAA domain AAA_21 PF13304.1 CCF37174.1 - 8.9e-06 25.8 0.0 0.009 16.0 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 CCF37174.1 - 1.3e-05 25.2 1.7 0.0038 17.2 0.1 3.1 3 1 0 3 3 2 1 AAA ATPase domain DUF258 PF03193.11 CCF37174.1 - 3e-05 23.2 0.0 8.8e-05 21.7 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF258 cobW PF02492.14 CCF37174.1 - 7.9e-05 22.1 0.0 0.005 16.3 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain T2SE PF00437.15 CCF37174.1 - 0.00038 19.4 0.0 0.26 10.1 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein NACHT PF05729.7 CCF37174.1 - 0.00058 19.5 0.1 0.095 12.3 0.0 2.8 3 0 0 3 3 2 1 NACHT domain MMR_HSR1 PF01926.18 CCF37174.1 - 0.0011 18.8 0.0 0.44 10.5 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_33 PF13671.1 CCF37174.1 - 0.0022 17.8 4.4 0.062 13.1 0.0 3.4 4 0 0 4 4 4 1 AAA domain AAA_19 PF13245.1 CCF37174.1 - 0.0022 17.6 0.1 0.41 10.4 0.1 2.6 2 0 0 2 2 2 1 Part of AAA domain AAA_18 PF13238.1 CCF37174.1 - 0.0024 18.1 0.0 0.04 14.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 CCF37174.1 - 0.0035 17.3 0.2 0.0035 17.3 0.1 2.7 3 0 0 3 3 2 1 AAA domain UPF0079 PF02367.12 CCF37174.1 - 0.0044 16.6 0.3 0.052 13.1 0.2 2.3 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 FtsK_SpoIIIE PF01580.13 CCF37174.1 - 0.0058 16.1 1.5 2.1 7.7 0.0 2.9 4 0 0 4 4 2 1 FtsK/SpoIIIE family RNA_helicase PF00910.17 CCF37174.1 - 0.027 14.6 0.0 3 8.0 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_10 PF12846.2 CCF37174.1 - 0.029 13.7 2.0 3.2 7.1 0.2 2.8 3 0 0 3 3 3 0 AAA-like domain Arch_ATPase PF01637.13 CCF37174.1 - 0.031 13.9 0.0 4.4 6.9 0.0 2.6 2 0 0 2 2 2 0 Archaeal ATPase Miro PF08477.8 CCF37174.1 - 0.032 14.7 0.0 3.7 8.0 0.0 3.0 2 0 0 2 2 2 0 Miro-like protein AAA_23 PF13476.1 CCF37174.1 - 0.045 14.0 0.1 0.045 14.0 0.1 3.3 3 1 0 3 3 2 0 AAA domain AAA PF00004.24 CCF37174.1 - 0.18 11.9 5.1 1 9.5 0.0 3.3 4 0 0 4 4 2 0 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.1 CCF37174.1 - 0.22 10.5 0.0 0.47 9.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Aminotran_3 PF00202.16 CCF37175.1 - 2e-22 79.5 1.2 2.2e-12 46.4 0.1 2.0 2 0 0 2 2 2 2 Aminotransferase class-III BTB PF00651.26 CCF37178.1 - 0.0048 16.8 0.0 0.0081 16.1 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BLVR PF06375.6 CCF37178.1 - 1.2 8.9 5.4 5.1 6.9 3.9 1.8 2 0 0 2 2 2 0 Bovine leukaemia virus receptor (BLVR) Peptidase_A4 PF01828.12 CCF37179.1 - 8.5e-38 129.4 0.6 1.1e-37 129.1 0.4 1.1 1 0 0 1 1 1 1 Peptidase A4 family TPP_enzyme_N PF02776.13 CCF37180.1 - 7.6e-56 188.2 0.1 5.2e-54 182.3 0.0 2.5 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 CCF37180.1 - 5.8e-51 172.0 0.2 1.2e-49 167.8 0.1 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 CCF37180.1 - 1.3e-36 125.4 2.3 1.3e-36 125.3 0.2 2.1 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, central domain ABC2_membrane PF01061.19 CCF37182.1 - 2.5e-84 281.6 64.7 1.8e-43 148.1 19.3 3.8 4 0 0 4 4 4 2 ABC-2 type transporter PDR_CDR PF06422.7 CCF37182.1 - 6.4e-39 131.7 3.6 7.2e-32 109.1 0.1 2.9 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.22 CCF37182.1 - 1.5e-37 128.9 0.1 2.9e-17 63.2 0.0 3.0 3 0 0 3 3 3 2 ABC transporter ABC_trans_N PF14510.1 CCF37182.1 - 4.1e-21 74.8 0.1 1.1e-20 73.4 0.0 1.8 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_25 PF13481.1 CCF37182.1 - 4.3e-09 36.0 0.1 1.1e-05 24.9 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.1 CCF37182.1 - 1.8e-06 28.1 0.9 0.00033 20.6 0.0 3.1 3 0 0 3 3 3 1 AAA ATPase domain AAA_33 PF13671.1 CCF37182.1 - 1.2e-05 25.1 0.6 0.0055 16.5 0.0 3.0 3 0 0 3 3 3 1 AAA domain DUF258 PF03193.11 CCF37182.1 - 3.6e-05 22.9 0.1 0.0037 16.4 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 cobW PF02492.14 CCF37182.1 - 0.00016 21.1 2.4 0.0014 18.1 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 CCF37182.1 - 0.0014 18.1 2.2 0.035 13.6 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.1 CCF37182.1 - 0.0021 18.3 0.1 0.047 13.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 CCF37182.1 - 0.011 16.6 0.0 0.17 12.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 CCF37182.1 - 0.011 15.4 0.9 1.7 8.2 0.1 2.5 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.1 CCF37182.1 - 0.011 15.8 1.8 0.74 9.9 0.0 3.2 3 1 0 3 3 2 0 AAA domain SMC_N PF02463.14 CCF37182.1 - 0.011 14.9 0.0 1.9 7.6 0.0 3.2 2 2 0 2 2 2 0 RecF/RecN/SMC N terminal domain Miro PF08477.8 CCF37182.1 - 0.023 15.1 0.1 9.1 6.8 0.0 2.6 2 0 0 2 2 2 0 Miro-like protein AAA_30 PF13604.1 CCF37182.1 - 0.052 13.1 0.1 3.3 7.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.17 CCF37182.1 - 0.078 13.1 0.1 23 5.2 0.0 2.7 2 0 0 2 2 2 0 RNA helicase MMR_HSR1 PF01926.18 CCF37182.1 - 0.079 12.9 0.0 9.4 6.2 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_21 PF13304.1 CCF37182.1 - 0.081 12.8 0.0 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 CCF37182.1 - 0.22 11.2 1.8 8.1 6.2 0.1 2.7 2 0 0 2 2 2 0 Part of AAA domain GMC_oxred_N PF00732.14 CCF37183.1 - 2.7e-50 171.2 0.1 1.1e-49 169.1 0.0 1.8 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF37183.1 - 1.4e-32 112.9 0.1 2.2e-32 112.3 0.1 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.7 CCF37183.1 - 3.2e-06 26.3 0.1 5.6e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.17 CCF37183.1 - 6e-05 22.0 0.0 0.05 12.4 0.0 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A DAO PF01266.19 CCF37183.1 - 0.0015 17.5 0.1 0.035 13.0 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF37183.1 - 0.017 15.0 0.1 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF37183.1 - 0.044 13.8 0.1 0.11 12.5 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Glyco_hydro_7 PF00840.15 CCF37184.1 - 7.3e-146 485.9 13.5 8.6e-146 485.6 9.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 Phage_FRD3 PF05798.6 CCF37184.1 - 0.02 15.1 0.0 0.042 14.1 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage FRD3 protein HET PF06985.6 CCF37185.1 - 1.2e-31 109.6 0.2 2e-31 108.9 0.1 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) FAINT PF04385.10 CCF37185.1 - 0.041 13.7 0.0 0.091 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function, DUF529 DUF3328 PF11807.3 CCF37186.1 - 5e-24 85.1 0.1 6.4e-24 84.8 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Peptidase_S10 PF00450.17 CCF37187.1 - 3.3e-73 247.2 0.1 4.3e-73 246.8 0.1 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Lipase_3 PF01764.20 CCF37187.1 - 0.043 13.4 0.0 0.098 12.2 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) AA_permease PF00324.16 CCF37189.1 - 4.4e-62 209.9 29.8 5.5e-62 209.6 20.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF37189.1 - 2.1e-16 59.5 33.8 4.5e-16 58.4 23.4 1.5 1 1 0 1 1 1 1 Amino acid permease DUF805 PF05656.9 CCF37189.1 - 0.09 12.6 0.1 0.09 12.6 0.1 3.8 4 1 0 4 4 4 0 Protein of unknown function (DUF805) Asp PF00026.18 CCF37190.1 - 4.5e-51 173.9 0.0 6.2e-51 173.5 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CCF37190.1 - 3.8e-08 33.4 0.0 1.6e-07 31.3 0.0 2.1 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 CCF37190.1 - 0.02 15.3 0.4 8.3 6.9 0.0 3.2 3 0 0 3 3 3 0 Aspartyl protease TAXi_C PF14541.1 CCF37190.1 - 0.047 13.2 0.2 0.8 9.2 0.1 2.5 2 1 0 2 2 2 0 Xylanase inhibitor C-terminal 2OG-FeII_Oxy_2 PF13532.1 CCF37191.1 - 1.3e-15 57.7 0.0 2.6e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Fer4_3 PF12798.2 CCF37192.1 - 0.54 10.9 0.2 0.54 10.9 0.1 2.5 3 1 0 3 3 3 0 4Fe-4S binding domain DUF4334 PF14232.1 CCF37193.1 - 4e-17 61.6 0.6 1.3e-16 60.0 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4334) GXWXG PF14231.1 CCF37193.1 - 7.1e-16 57.6 0.5 1.3e-15 56.7 0.3 1.5 1 0 0 1 1 1 1 GXWXG protein DUF3328 PF11807.3 CCF37194.1 - 2.6e-12 46.8 0.4 3.1e-12 46.6 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) MM_CoA_mutase PF01642.17 CCF37194.1 - 0.12 10.4 0.0 0.16 10.1 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl-CoA mutase GPI2 PF06432.6 CCF37195.1 - 3.9e-39 134.7 0.1 4.8e-39 134.3 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase DUF3136 PF11334.3 CCF37195.1 - 0.085 12.2 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3136) DFP PF04127.10 CCF37196.1 - 0.013 15.1 0.0 0.017 14.7 0.0 1.1 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Glyco_hydro_61 PF03443.9 CCF37197.1 - 2.5e-62 210.5 0.1 3.2e-62 210.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 TMEM171 PF15471.1 CCF37197.1 - 1.8 7.2 6.0 2.5 6.7 4.2 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 COesterase PF00135.23 CCF37198.1 - 6.7e-84 282.5 2.1 1.1e-83 281.7 1.4 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF37198.1 - 1.1e-05 25.0 0.1 5.5e-05 22.8 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF37198.1 - 0.00083 18.6 0.1 0.00083 18.6 0.1 2.2 2 1 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CCF37198.1 - 0.037 13.7 0.0 0.068 12.9 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family ABC1 PF03109.11 CCF37199.1 - 1.8e-24 85.9 0.0 6.4e-15 55.1 0.0 2.8 2 1 1 3 3 3 2 ABC1 family APH PF01636.18 CCF37199.1 - 0.0016 18.2 1.3 0.0053 16.5 0.1 2.5 3 1 1 4 4 4 1 Phosphotransferase enzyme family SCP2 PF02036.12 CCF37202.1 - 5.7e-26 90.7 0.3 7.1e-26 90.4 0.2 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.1 CCF37202.1 - 5.3e-05 23.1 0.2 8.2e-05 22.5 0.1 1.4 1 1 0 1 1 1 1 Alkyl sulfatase C-terminal Ran_BP1 PF00638.13 CCF37203.1 - 1.7e-10 40.9 0.0 8.6e-10 38.7 0.0 2.0 1 1 0 1 1 1 1 RanBP1 domain Nucleoporin_FG PF13634.1 CCF37203.1 - 8.3e-06 26.0 22.7 8.3e-06 26.0 15.7 8.5 2 1 5 7 7 7 4 Nucleoporin FG repeat region DUF92 PF01940.11 CCF37204.1 - 8.1e-67 224.6 2.5 1.1e-66 224.2 1.8 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF92 Mito_carr PF00153.22 CCF37205.1 - 1.2e-41 140.3 3.0 5.3e-17 61.3 0.0 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L22e PF01776.12 CCF37206.1 - 3.7e-48 162.1 1.6 4.6e-48 161.8 1.1 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Herpes_gI PF01688.12 CCF37206.1 - 0.15 11.1 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein I DPBB_1 PF03330.13 CCF37207.1 - 1.8e-08 34.2 0.0 1.8e-08 34.2 0.0 2.5 3 0 0 3 3 3 1 Rare lipoprotein A (RlpA)-like double-psi beta-barrel Barwin PF00967.12 CCF37207.1 - 1.7e-06 27.6 0.3 3.3e-06 26.7 0.2 1.4 1 0 0 1 1 1 1 Barwin family Cerato-platanin PF07249.7 CCF37207.1 - 0.0056 16.6 0.3 0.0096 15.9 0.2 1.4 1 0 0 1 1 1 1 Cerato-platanin Pollen_allerg_1 PF01357.16 CCF37207.1 - 0.022 14.5 0.2 0.044 13.6 0.1 1.5 1 0 0 1 1 1 0 Pollen allergen BNR PF02012.15 CCF37207.1 - 0.024 14.3 0.3 0.074 12.9 0.2 1.9 1 0 0 1 1 1 0 BNR/Asp-box repeat EF-hand_1 PF00036.27 CCF37209.1 - 4.1e-12 44.4 6.5 3.9e-05 22.6 0.3 3.9 3 0 0 3 3 3 3 EF hand ZZ PF00569.12 CCF37209.1 - 5.3e-11 41.8 7.8 9.3e-11 41.0 5.4 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type EF-hand_7 PF13499.1 CCF37209.1 - 6.3e-08 32.6 6.4 4.7e-06 26.6 2.8 3.4 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.1 CCF37209.1 - 3.4e-07 29.5 5.9 0.0016 18.1 0.3 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.1 CCF37209.1 - 1.9e-05 24.1 3.5 0.078 12.6 0.0 3.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.2 CCF37209.1 - 0.019 14.6 0.7 0.12 12.1 0.0 2.7 3 1 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand C1_3 PF07649.7 CCF37209.1 - 0.032 14.2 9.0 0.063 13.3 6.2 1.5 1 0 0 1 1 1 0 C1-like domain EF-hand_5 PF13202.1 CCF37209.1 - 0.55 9.6 11.0 0.65 9.4 0.7 3.6 3 0 0 3 3 3 0 EF hand adh_short PF00106.20 CCF37211.1 - 7.1e-18 65.0 4.1 4.9e-17 62.3 2.6 2.2 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF37211.1 - 3.9e-10 39.8 0.0 1.2e-09 38.2 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF37211.1 - 1.2e-09 38.0 2.6 3e-08 33.5 1.9 2.3 1 1 1 2 2 2 1 KR domain NAD_binding_10 PF13460.1 CCF37211.1 - 0.0041 17.1 0.5 0.02 14.9 0.3 1.9 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF37211.1 - 0.0049 16.3 0.2 0.0074 15.7 0.2 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.13 CCF37211.1 - 0.045 13.4 0.3 0.074 12.6 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain N1221 PF07923.8 CCF37211.1 - 0.082 11.7 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 N1221-like protein HTH_15 PF12324.3 CCF37211.1 - 0.11 12.1 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of alkylmercury lyase FAD_binding_3 PF01494.14 CCF37212.1 - 1.1e-58 199.0 0.5 2.4e-31 109.0 0.1 2.8 2 1 0 2 2 2 2 FAD binding domain DAO PF01266.19 CCF37212.1 - 3.8e-07 29.3 0.4 1.2e-06 27.7 0.1 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF37212.1 - 2.5e-06 27.4 0.0 6.9e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 CCF37212.1 - 2.9e-05 23.2 0.0 4.6e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.9 CCF37212.1 - 0.0019 18.1 0.1 0.011 15.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF37212.1 - 0.0019 18.2 0.0 0.0043 17.1 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF37212.1 - 0.008 16.5 0.0 0.018 15.4 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF37212.1 - 0.014 13.8 0.0 0.02 13.3 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein ApbA PF02558.11 CCF37212.1 - 0.042 13.2 0.0 0.08 12.3 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ThiF PF00899.16 CCF37212.1 - 0.054 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 ThiF family UDPG_MGDP_dh_N PF03721.9 CCF37212.1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.13 CCF37212.1 - 0.17 11.5 1.4 0.5 9.9 0.0 2.4 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain LysM PF01476.15 CCF37214.1 - 8.8e-05 22.3 0.0 0.00012 21.8 0.0 1.2 1 0 0 1 1 1 1 LysM domain Aldo_ket_red PF00248.16 CCF37215.1 - 7.3e-70 235.0 0.0 8.3e-70 234.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family IDEAL PF08858.5 CCF37215.1 - 0.078 12.4 0.3 0.2 11.1 0.2 1.7 1 0 0 1 1 1 0 IDEAL domain Amidohydro_3 PF07969.6 CCF37217.1 - 6.5e-62 210.0 0.2 7.7e-62 209.8 0.2 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.15 CCF37217.1 - 0.00015 21.5 0.0 0.0087 15.7 0.0 2.4 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_5 PF13594.1 CCF37217.1 - 0.0065 16.2 0.2 0.029 14.1 0.0 2.2 2 0 0 2 2 2 1 Amidohydrolase WSC PF01822.14 CCF37218.1 - 7.1e-12 45.0 9.6 7.1e-12 45.0 6.6 2.0 2 0 0 2 2 2 1 WSC domain SKG6 PF08693.5 CCF37218.1 - 0.00059 19.0 0.2 0.0015 17.8 0.2 1.8 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4366 PF14283.1 CCF37218.1 - 0.0028 17.1 0.5 0.012 15.0 0.4 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4366) Trp_oprn_chp PF09534.5 CCF37218.1 - 0.0032 17.1 0.1 0.0032 17.1 0.0 1.7 2 1 0 2 2 2 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Podoplanin PF05808.6 CCF37218.1 - 0.015 14.8 9.3 0.026 14.0 6.4 1.3 1 0 0 1 1 1 0 Podoplanin MoeZ_MoeB PF05237.8 CCF37218.1 - 0.067 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 MoeZ/MoeB domain IncA PF04156.9 CCF37218.1 - 0.08 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 IncA protein TMEM154 PF15102.1 CCF37218.1 - 0.09 12.4 2.1 0.3 10.7 1.4 1.9 1 1 0 1 1 1 0 TMEM154 protein family Adeno_E3_CR2 PF02439.10 CCF37218.1 - 0.15 11.6 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 NAD_binding_4 PF07993.7 CCF37219.1 - 6.6e-42 143.1 0.0 1e-41 142.5 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.16 CCF37219.1 - 2.7e-17 63.0 0.0 4e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF37219.1 - 4e-11 42.1 0.0 5.6e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family PP-binding PF00550.20 CCF37219.1 - 1.5e-09 37.9 0.4 2.9e-09 37.0 0.3 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site RmlD_sub_bind PF04321.12 CCF37219.1 - 0.0001 21.2 0.0 0.092 11.6 0.0 2.3 2 0 0 2 2 2 2 RmlD substrate binding domain NAD_binding_10 PF13460.1 CCF37219.1 - 0.0015 18.6 0.1 0.0035 17.3 0.0 1.6 2 0 0 2 2 2 1 NADH(P)-binding ketoacyl-synt PF00109.21 CCF37220.1 - 6.1e-60 202.8 0.0 7e-60 202.6 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.18 CCF37220.1 - 1.7e-05 23.9 0.1 2.6e-05 23.3 0.1 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 CCF37220.1 - 0.0013 18.3 0.1 0.0022 17.5 0.1 1.4 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III p450 PF00067.17 CCF37221.1 - 1.3e-30 106.3 0.0 1.5e-30 106.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SET PF00856.23 CCF37223.1 - 5.6 7.2 8.4 18 5.6 5.8 2.3 1 1 0 1 1 1 0 SET domain PP2C PF00481.16 CCF37224.1 - 6.7e-31 107.5 0.0 1.5e-30 106.4 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C TPK_catalytic PF04263.11 CCF37226.1 - 0.38 10.3 0.0 0.38 10.3 0.0 2.5 3 0 0 3 3 3 0 Thiamin pyrophosphokinase, catalytic domain Reo_sigmaC PF04582.7 CCF37226.1 - 0.48 9.5 12.6 0.015 14.4 2.7 2.2 2 1 0 2 2 2 0 Reovirus sigma C capsid protein OST3_OST6 PF04756.8 CCF37227.1 - 1.2e-22 80.2 0.5 1.7e-22 79.7 0.4 1.2 1 0 0 1 1 1 1 OST3 / OST6 family DUF2561 PF10812.3 CCF37227.1 - 0.046 13.3 0.1 0.072 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) DUF1129 PF06570.6 CCF37227.1 - 2.2 7.5 4.0 18 4.5 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) WD40 PF00400.27 CCF37228.1 - 8.7e-62 202.9 22.2 1.2e-11 43.9 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 CCF37228.1 - 1.3e-05 23.5 6.7 0.23 9.5 0.1 4.0 1 1 4 5 5 5 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 CCF37228.1 - 0.03 12.6 0.0 3.4 5.8 0.1 2.2 2 0 0 2 2 2 0 Cytochrome D1 heme domain TAF8_C PF10406.4 CCF37229.1 - 3.7e-15 55.6 1.4 1.4e-14 53.8 0.1 2.3 2 0 0 2 2 2 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.8 CCF37229.1 - 8.6e-12 44.6 0.0 1.3e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated LRR_4 PF12799.2 CCF37230.1 - 7e-21 73.4 0.0 5.9e-05 22.5 0.0 5.1 2 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CCF37230.1 - 2.1e-13 49.8 0.8 1.2e-07 31.3 0.2 3.9 2 2 3 5 5 5 4 Leucine rich repeat LRR_1 PF00560.28 CCF37230.1 - 5.8e-13 46.9 0.1 0.0034 17.2 0.0 6.8 7 0 0 7 7 7 3 Leucine Rich Repeat LRR_7 PF13504.1 CCF37230.1 - 1.6e-07 30.4 4.8 3.7 8.1 0.1 7.3 8 0 0 8 8 8 2 Leucine rich repeat LRR_6 PF13516.1 CCF37230.1 - 0.034 14.2 4.0 3.9 7.8 0.1 4.4 3 2 0 3 3 3 0 Leucine Rich repeat bZIP_1 PF00170.16 CCF37231.1 - 2.4e-10 40.1 7.3 5.7e-10 39.0 5.1 1.7 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.12 CCF37231.1 - 0.00066 19.9 0.8 0.00066 19.9 0.6 2.2 2 0 0 2 2 2 1 bZIP Maf transcription factor bZIP_2 PF07716.10 CCF37231.1 - 0.001 18.8 8.9 0.001 18.8 6.2 2.2 2 0 0 2 2 2 1 Basic region leucine zipper Hamartin PF04388.7 CCF37231.1 - 0.47 9.0 6.6 0.57 8.7 4.6 1.2 1 0 0 1 1 1 0 Hamartin protein DUF4140 PF13600.1 CCF37231.1 - 1.1 9.6 5.3 0.46 10.9 0.3 2.5 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) p450 PF00067.17 CCF37232.1 - 6.6e-63 212.8 0.0 7.8e-63 212.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Rhodanese PF00581.15 CCF37233.1 - 0.0034 17.7 0.0 0.0061 16.9 0.0 1.4 1 1 0 1 1 1 1 Rhodanese-like domain Ilar_coat PF01787.11 CCF37234.1 - 0.11 12.1 3.6 0.12 11.9 2.5 1.2 1 0 0 1 1 1 0 Ilarvirus coat protein DUF3752 PF12572.3 CCF37235.1 - 3.8e-38 130.9 10.9 3.8e-38 130.9 7.6 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3752) Vfa1 PF08432.5 CCF37235.1 - 0.48 10.4 5.0 1.3 9.0 3.5 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Vps8 PF12816.2 CCF37236.1 - 8.5e-40 136.0 0.7 1.4e-39 135.3 0.5 1.3 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 TauD PF02668.11 CCF37237.1 - 5.3e-33 114.7 0.1 6.8e-33 114.4 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DDA1 PF10172.4 CCF37237.1 - 0.049 13.4 0.2 1.5 8.6 0.0 2.3 2 0 0 2 2 2 0 Det1 complexing ubiquitin ligase Aldo_ket_red PF00248.16 CCF37238.1 - 1.9e-45 154.8 0.0 2.4e-45 154.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Voltage_CLC PF00654.15 CCF37240.1 - 1e-90 304.3 27.3 1e-90 304.3 18.9 1.4 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.23 CCF37240.1 - 0.0023 17.6 0.0 0.024 14.4 0.0 2.3 2 0 0 2 2 2 1 CBS domain Sel1 PF08238.7 CCF37243.1 - 7.9e-15 54.9 0.2 7.8e-05 23.1 0.0 3.6 3 0 0 3 3 3 3 Sel1 repeat TraC PF07820.7 CCF37243.1 - 0.012 15.7 0.1 0.035 14.2 0.1 1.7 1 0 0 1 1 1 0 TraC-like protein Dopey_N PF04118.9 CCF37244.1 - 6.4e-121 402.8 0.0 8.9e-121 402.4 0.0 1.2 1 0 0 1 1 1 1 Dopey, N-terminal Mon1 PF03164.9 CCF37245.1 - 3e-113 378.5 0.0 3.6e-113 378.3 0.0 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 Sporozoite_P67 PF05642.6 CCF37246.1 - 1.3 6.7 8.7 1.7 6.4 6.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF3357 PF11837.3 CCF37248.1 - 0.0095 15.7 0.1 0.027 14.3 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3357) AAA PF00004.24 CCF37249.1 - 2.7e-09 37.3 0.5 5.1e-08 33.1 0.3 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF37249.1 - 0.00017 21.6 0.1 0.0021 18.0 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 CCF37249.1 - 0.00029 20.9 0.2 0.0026 17.8 0.0 2.5 2 1 0 2 2 2 1 AAA domain Rad17 PF03215.10 CCF37249.1 - 0.0003 19.6 0.0 0.0035 16.0 0.0 2.2 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_17 PF13207.1 CCF37249.1 - 0.0017 19.1 0.0 0.0045 17.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 CCF37249.1 - 0.0093 15.8 0.0 0.037 13.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 CCF37249.1 - 0.047 12.4 0.0 0.071 11.8 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus AAA_28 PF13521.1 CCF37249.1 - 0.069 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 CCF37249.1 - 0.11 12.6 0.0 0.33 11.1 0.0 1.8 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.10 CCF37249.1 - 0.12 12.0 0.0 2 8.0 0.0 2.3 2 0 0 2 2 2 0 NTPase AAA_18 PF13238.1 CCF37249.1 - 0.18 12.1 0.0 0.83 9.9 0.0 2.1 1 1 0 1 1 1 0 AAA domain DUF1741 PF08427.5 CCF37252.1 - 8.1e-81 270.9 0.0 1.4e-80 270.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) TraQ PF09679.5 CCF37252.1 - 0.041 13.8 0.0 0.12 12.3 0.0 1.8 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin chaperone (TraQ) FMN_red PF03358.10 CCF37253.1 - 3.5e-25 88.3 0.0 4.8e-25 87.8 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 CCF37253.1 - 2.3e-05 23.9 0.0 3.1e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold Asp PF00026.18 CCF37254.1 - 5e-29 101.5 0.0 6.3e-28 97.9 0.0 2.0 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CCF37254.1 - 2.5e-05 24.2 0.0 5.9e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Glyco_hydro_18 PF00704.23 CCF37255.1 - 5.1e-08 32.7 0.1 5.6e-08 32.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Mito_carr PF00153.22 CCF37256.1 - 5e-59 196.0 3.6 3.9e-19 68.1 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Phage_Coat_B PF05356.6 CCF37256.1 - 0.038 13.6 0.7 2.3 7.9 0.0 2.9 3 0 0 3 3 3 0 Phage Coat protein B PNP_UDP_1 PF01048.15 CCF37257.1 - 7.2e-12 44.7 0.4 1.6e-10 40.4 0.2 2.4 1 1 0 1 1 1 1 Phosphorylase superfamily DDE_1 PF03184.14 CCF37258.1 - 1.5e-33 115.7 0.0 3e-33 114.8 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.11 CCF37258.1 - 2.8e-14 52.3 0.2 5.5e-14 51.4 0.2 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF37258.1 - 4e-12 45.7 0.1 1.5e-11 43.9 0.0 2.0 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.1 CCF37258.1 - 0.00014 21.4 0.0 0.00046 19.7 0.0 2.0 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 CCF37258.1 - 0.00061 19.7 0.1 0.0019 18.1 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_7 PF02796.10 CCF37258.1 - 0.0014 18.4 0.1 0.0029 17.4 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.1 CCF37258.1 - 0.005 16.4 0.1 0.012 15.2 0.0 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_1 PF00126.22 CCF37258.1 - 0.075 12.7 0.9 0.18 11.5 0.6 1.6 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family SpoIIID PF12116.3 CCF37258.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Stage III sporulation protein D CENP-B_N PF04218.8 CCF37258.1 - 0.13 11.6 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain adh_short PF00106.20 CCF37259.1 - 7.5e-16 58.4 1.1 1.4e-15 57.5 0.7 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF37259.1 - 3.2e-08 33.4 0.4 6.2e-08 32.5 0.3 1.5 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF37259.1 - 0.0038 17.0 0.0 0.0074 16.0 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.3 CCF37259.1 - 0.0068 16.1 0.3 0.013 15.2 0.2 1.5 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Strep_pep PF14404.1 CCF37259.1 - 0.058 13.6 0.1 0.16 12.2 0.0 1.7 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Streptomyces species DUF3873 PF12989.2 CCF37260.1 - 0.13 12.3 0.3 0.22 11.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) Spo7 PF03907.8 CCF37261.1 - 5.3e-69 232.0 0.1 7.2e-69 231.5 0.0 1.1 1 0 0 1 1 1 1 Spo7-like protein p450 PF00067.17 CCF37264.1 - 3.2e-53 180.8 0.0 4e-53 180.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NmrA PF05368.8 CCF37265.1 - 3e-25 88.8 0.0 5.8e-25 87.9 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF37265.1 - 1.4e-17 64.2 0.1 2e-17 63.8 0.1 1.2 1 0 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 CCF37265.1 - 0.091 11.7 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase NAD_binding_4 PF07993.7 CCF37266.1 - 5.3e-44 150.0 0.0 9.5e-44 149.1 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.23 CCF37266.1 - 3.1e-38 131.2 0.0 1.8e-37 128.7 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme Epimerase PF01370.16 CCF37266.1 - 3.1e-13 49.7 0.0 6.4e-12 45.4 0.0 2.4 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family AAA_33 PF13671.1 CCF37266.1 - 3.2e-12 46.5 0.0 8.1e-12 45.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain PP-binding PF00550.20 CCF37266.1 - 8.8e-10 38.7 0.8 2.5e-09 37.2 0.1 2.1 2 0 0 2 2 1 1 Phosphopantetheine attachment site AAA_17 PF13207.1 CCF37266.1 - 2.9e-09 37.8 0.0 1.1e-08 35.8 0.0 2.1 1 0 0 1 1 1 1 AAA domain SKI PF01202.17 CCF37266.1 - 5e-08 32.9 0.0 9.4e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Shikimate kinase AAA_18 PF13238.1 CCF37266.1 - 3.4e-06 27.3 0.0 8.8e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain adh_short PF00106.20 CCF37266.1 - 4.1e-06 26.8 1.8 7.3e-05 22.7 0.3 2.9 2 0 0 2 2 2 1 short chain dehydrogenase AAA_25 PF13481.1 CCF37266.1 - 1.8e-05 24.2 0.0 4.3e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain KR PF08659.5 CCF37266.1 - 4e-05 23.3 1.7 0.0084 15.7 0.3 2.9 3 0 0 3 3 3 1 KR domain APS_kinase PF01583.15 CCF37266.1 - 6.2e-05 22.7 0.0 0.00011 21.8 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase 3Beta_HSD PF01073.14 CCF37266.1 - 0.0021 16.8 0.0 0.007 15.0 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family MobB PF03205.9 CCF37266.1 - 0.0066 16.1 0.0 0.016 14.9 0.0 1.7 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_PrkA PF08298.6 CCF37266.1 - 0.012 14.3 0.0 0.021 13.5 0.0 1.3 1 0 0 1 1 1 0 PrkA AAA domain AAA PF00004.24 CCF37266.1 - 0.023 14.9 0.0 0.049 13.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) T2SE PF00437.15 CCF37266.1 - 0.029 13.2 0.3 0.38 9.6 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_22 PF13401.1 CCF37266.1 - 0.034 14.2 0.0 0.11 12.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CCF37266.1 - 0.035 14.1 0.2 0.19 11.7 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.7 CCF37266.1 - 0.042 12.9 0.0 0.096 11.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin CoaE PF01121.15 CCF37266.1 - 0.046 13.1 0.0 0.085 12.2 0.0 1.4 1 0 0 1 1 1 0 Dephospho-CoA kinase AAA_29 PF13555.1 CCF37266.1 - 0.056 12.9 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain CPT PF07931.7 CCF37266.1 - 0.068 12.7 0.1 0.24 11.0 0.0 2.0 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Semialdhyde_dh PF01118.19 CCF37266.1 - 0.08 13.2 0.0 0.23 11.7 0.0 1.8 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain AAA_5 PF07728.9 CCF37266.1 - 0.081 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 CCF37266.1 - 0.097 12.0 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Cytidylate_kin2 PF13189.1 CCF37266.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Cytidylate kinase-like family PRK PF00485.13 CCF37266.1 - 0.13 11.8 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family NACHT PF05729.7 CCF37266.1 - 0.19 11.3 0.0 0.43 10.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain DHDPS PF00701.17 CCF37267.1 - 4.3e-40 137.1 0.0 5e-40 136.9 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family MFS_1 PF07690.11 CCF37268.1 - 1.8e-30 105.8 22.3 1.8e-30 105.8 15.5 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily MarR_2 PF12802.2 CCF37269.1 - 0.06 13.0 0.1 0.14 11.8 0.1 1.6 1 0 0 1 1 1 0 MarR family CENP-Q PF13094.1 CCF37269.1 - 0.93 9.5 4.7 0.17 11.8 0.3 1.9 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Acetyltransf_1 PF00583.19 CCF37270.1 - 9.5e-17 60.8 0.0 1.3e-16 60.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF37270.1 - 3.3e-07 30.3 0.0 6.6e-07 29.3 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CCF37270.1 - 2.9e-06 27.3 0.0 4.3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF37270.1 - 5.2e-06 26.1 0.0 8.6e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.1 CCF37270.1 - 1.6e-05 24.8 0.0 2.1e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 CCF37270.1 - 0.00029 20.6 0.0 0.00049 19.9 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 CCF37270.1 - 0.0035 17.3 0.0 0.0053 16.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain adh_short PF00106.20 CCF37271.1 - 4.2e-27 95.1 0.9 5.2e-27 94.7 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF37271.1 - 2.1e-26 93.1 0.0 2.6e-26 92.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF37271.1 - 6.6e-11 42.1 0.8 8.7e-11 41.8 0.5 1.1 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.13 CCF37271.1 - 0.04 13.5 0.1 0.063 12.9 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1379 PF07126.7 CCF37271.1 - 0.14 11.5 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1379) Acyltransferase PF01553.16 CCF37272.1 - 3.5e-33 113.8 0.0 5.3e-33 113.2 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Ribonuc_L-PSP PF01042.16 CCF37272.1 - 0.064 13.0 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Endoribonuclease L-PSP TAF8_C PF10406.4 CCF37273.1 - 0.037 14.0 0.0 0.078 13.0 0.0 1.5 1 0 0 1 1 1 0 Transcription factor TFIID complex subunit 8 C-term RHINO PF15319.1 CCF37273.1 - 0.052 13.3 0.2 0.061 13.1 0.1 1.0 1 0 0 1 1 1 0 RAD9, RAD1, HUS1-interacting nuclear orphan protein Rap1-DNA-bind PF09197.5 CCF37273.1 - 0.11 13.0 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 Rap1, DNA-binding ATP-synt_DE_N PF02823.11 CCF37276.1 - 3.8e-19 68.2 0.1 6.2e-19 67.5 0.0 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain F-box PF00646.28 CCF37277.1 - 0.032 13.8 0.1 0.091 12.4 0.1 1.8 1 0 0 1 1 1 0 F-box domain Na_H_Exchanger PF00999.16 CCF37279.1 - 2.3e-30 105.3 10.8 3e-30 105.0 7.5 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family YrhC PF14143.1 CCF37279.1 - 2.5 8.0 8.9 0.18 11.7 0.2 3.4 4 1 0 4 4 4 0 YrhC-like protein OCD_Mu_crystall PF02423.10 CCF37280.1 - 5e-14 51.7 0.8 1.8e-07 30.2 0.0 2.9 3 0 0 3 3 3 2 Ornithine cyclodeaminase/mu-crystallin family Trehalase PF01204.13 CCF37281.1 - 2.5e-07 29.7 3.4 3e-07 29.4 2.4 1.1 1 0 0 1 1 1 1 Trehalase Fer2 PF00111.22 CCF37282.1 - 0.4 10.4 3.3 0.69 9.6 2.3 1.4 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Band_7 PF01145.20 CCF37283.1 - 8.8e-24 84.3 2.6 1.4e-23 83.7 1.8 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family E_Pc_C PF06752.7 CCF37283.1 - 0.026 14.0 0.2 0.039 13.4 0.1 1.3 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus ubiquitin PF00240.18 CCF37284.1 - 1.6e-24 85.0 0.1 1.8e-24 84.9 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 CCF37284.1 - 1.2e-14 53.7 0.1 1.3e-14 53.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 CCF37284.1 - 0.00013 22.1 0.1 0.00044 20.4 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain JmjC PF02373.17 CCF37285.1 - 1.8e-10 41.0 0.1 6.3e-10 39.3 0.1 1.9 1 1 0 1 1 1 1 JmjC domain, hydroxylase zf-4CXXC_R1 PF10497.4 CCF37285.1 - 3.7e-06 27.0 10.7 3.7e-06 27.0 7.4 2.9 2 1 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Cupin_2 PF07883.6 CCF37285.1 - 0.0024 17.3 0.0 0.0058 16.0 0.0 1.6 1 0 0 1 1 1 1 Cupin domain AT_hook PF02178.14 CCF37285.1 - 0.089 12.5 19.7 0.81 9.5 3.3 3.1 2 0 0 2 2 2 0 AT hook motif WD40 PF00400.27 CCF37286.1 - 8.2e-39 130.1 8.3 2.1e-07 30.5 0.1 7.9 8 0 0 8 8 8 6 WD domain, G-beta repeat F-box-like PF12937.2 CCF37286.1 - 1.3e-12 47.2 0.5 3e-12 46.0 0.3 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF37286.1 - 2.8e-05 23.6 0.1 0.00013 21.5 0.1 2.0 2 0 0 2 2 2 1 F-box domain Nup160 PF11715.3 CCF37286.1 - 0.0087 14.2 0.1 2 6.4 0.0 2.3 2 0 0 2 2 2 2 Nucleoporin Nup120/160 PSI_PsaF PF02507.10 CCF37287.1 - 0.11 12.0 0.3 0.94 9.0 0.0 1.9 1 1 1 2 2 2 0 Photosystem I reaction centre subunit III YTH PF04146.10 CCF37288.1 - 4.5e-56 188.3 0.0 7.6e-56 187.5 0.0 1.4 1 0 0 1 1 1 1 YT521-B-like domain RRM_6 PF14259.1 CCF37288.1 - 0.0025 17.7 0.0 0.0082 16.0 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CCF37288.1 - 0.0045 16.6 0.0 0.011 15.3 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF37288.1 - 0.076 12.8 0.1 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aldo_ket_red PF00248.16 CCF37289.1 - 1.2e-12 47.2 0.0 1.3e-12 47.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family GPP34 PF05719.6 CCF37290.1 - 1.1e-65 221.5 0.2 1.5e-65 221.1 0.1 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) SURF6 PF04935.7 CCF37291.1 - 4.9e-42 143.6 28.7 6.2e-42 143.3 19.9 1.0 1 0 0 1 1 1 1 Surfeit locus protein 6 CAF-1_p150 PF11600.3 CCF37291.1 - 0.0034 16.8 28.9 0.0042 16.4 20.0 1.0 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal CT47 PF15623.1 CCF37291.1 - 1.7 8.3 10.7 2.2 7.9 7.4 1.1 1 0 0 1 1 1 0 Cancer/testis gene family 47 DNA_pol_viral_N PF00242.12 CCF37291.1 - 2.6 7.0 7.1 3.3 6.6 4.9 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain DUF3584 PF12128.3 CCF37291.1 - 7.3 3.7 17.6 8.6 3.5 12.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) FRG2 PF15315.1 CCF37291.1 - 7.4 6.5 14.5 6.3 6.7 9.3 1.4 1 1 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 Rpr2 PF04032.11 CCF37292.1 - 3.5e-08 33.2 0.0 7.4e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Zn_Tnp_IS1595 PF12760.2 CCF37292.1 - 0.085 12.6 0.5 3.4 7.5 0.1 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain PX PF00787.19 CCF37292.1 - 0.12 12.1 0.2 0.34 10.7 0.1 1.7 1 1 0 1 1 1 0 PX domain zf-PHD-like PF15446.1 CCF37292.1 - 0.14 11.4 0.6 0.17 11.1 0.4 1.3 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain DUF3133 PF11331.3 CCF37292.1 - 0.16 11.5 2.8 8.6 6.0 0.2 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3133) Nudix_N_2 PF14803.1 CCF37292.1 - 0.33 10.6 3.0 0.69 9.6 0.3 2.3 2 0 0 2 2 2 0 Nudix N-terminal DUF2464 PF10240.4 CCF37292.1 - 0.61 9.3 3.5 0.92 8.8 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2464) Met_10 PF02475.11 CCF37293.1 - 0.00027 20.5 0.0 0.0015 18.1 0.0 2.0 1 1 0 1 1 1 1 Met-10+ like-protein Methyltransf_26 PF13659.1 CCF37293.1 - 0.00039 20.4 0.1 0.00083 19.3 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain EF-hand_6 PF13405.1 CCF37294.1 - 2.2e-06 27.0 0.4 0.092 12.6 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 CCF37294.1 - 0.00048 19.2 0.1 0.0023 17.1 0.0 2.1 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 CCF37294.1 - 0.00053 19.2 0.0 0.002 17.4 0.0 1.9 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 CCF37294.1 - 0.018 15.1 1.9 0.018 15.1 1.3 2.2 2 1 0 2 2 2 0 EF-hand domain pair ORC6 PF05460.8 CCF37295.1 - 5.3e-43 147.4 0.0 8.9e-43 146.7 0.0 1.3 1 1 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) Tyrosinase PF00264.15 CCF37296.1 - 1.9e-50 172.1 0.0 2.5e-50 171.7 0.0 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase Fungal_trans PF04082.13 CCF37297.1 - 6.1e-08 31.8 0.5 1.4e-07 30.7 0.0 1.9 2 1 0 2 2 2 1 Fungal specific transcription factor domain ADH_zinc_N PF00107.21 CCF37298.1 - 4.2e-23 81.3 0.6 6.8e-23 80.6 0.4 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF37298.1 - 3.8e-11 43.9 0.1 9.6e-11 42.6 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF37298.1 - 7.6e-10 38.5 0.0 5e-09 35.9 0.0 2.2 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.16 CCF37298.1 - 0.019 14.5 0.0 0.03 13.8 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Na_Ca_ex PF01699.19 CCF37299.1 - 1.5e-27 95.8 31.2 4.4e-16 58.7 8.5 2.8 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Conotoxin PF02950.12 CCF37300.1 - 0.12 13.1 2.5 0.15 12.8 1.7 1.3 1 0 0 1 1 1 0 Conotoxin Toxin_19 PF08088.7 CCF37300.1 - 0.71 9.8 9.2 0.22 11.4 4.7 1.4 2 0 0 2 2 2 0 Conotoxin I-superfamily P21-Arc PF04062.9 CCF37301.1 - 2.2e-11 43.8 0.0 9.5e-11 41.7 0.0 1.9 1 1 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit MR_MLE_C PF13378.1 CCF37303.1 - 4.7e-35 119.9 0.0 9e-35 119.0 0.0 1.5 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.11 CCF37303.1 - 3.8e-10 39.7 0.0 8.9e-10 38.5 0.0 1.6 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MR_MLE PF01188.16 CCF37303.1 - 8.6e-09 35.7 0.0 2.3e-08 34.4 0.0 1.7 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain Amidohydro_2 PF04909.9 CCF37303.1 - 0.044 13.3 0.2 0.17 11.4 0.1 1.9 1 1 0 1 1 1 0 Amidohydrolase Fungal_trans_2 PF11951.3 CCF37304.1 - 6.9e-05 21.6 0.0 0.00017 20.3 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2422 PF10337.4 CCF37305.1 - 2.7 6.6 4.0 4.3 6.0 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) ResIII PF04851.10 CCF37306.1 - 1.6e-23 83.4 0.0 3.8e-23 82.2 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 CCF37306.1 - 3.2e-12 46.2 0.0 6.5e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF37306.1 - 2.8e-08 33.4 0.1 1.6e-07 31.1 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF2075 PF09848.4 CCF37306.1 - 0.0027 16.7 0.0 0.0046 15.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 CCF37306.1 - 0.071 13.2 0.0 0.18 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 CCF37306.1 - 0.073 12.6 0.0 1.8 8.0 0.0 2.4 1 1 1 2 2 2 0 AAA domain DUF3328 PF11807.3 CCF37307.1 - 2.8e-23 82.7 2.5 2.8e-23 82.7 1.7 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF3328) Baculo_PEP_C PF04513.7 CCF37308.1 - 2.6 7.8 11.0 0.24 11.2 1.5 2.5 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF202 PF02656.10 CCF37309.1 - 2.2e-25 88.6 1.1 2.2e-25 88.6 0.8 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) ATP_bind_4 PF01902.12 CCF37310.1 - 6e-19 68.2 0.0 2.3e-15 56.5 0.0 3.0 2 1 0 2 2 2 2 ATP-binding region Ribonuc_L-PSP PF01042.16 CCF37310.1 - 5.1e-11 42.3 0.1 7.9e-07 28.8 0.0 4.1 4 0 0 4 4 4 2 Endoribonuclease L-PSP Uma2 PF05685.7 CCF37310.1 - 0.025 13.9 0.1 0.055 12.8 0.1 1.5 1 0 0 1 1 1 0 Putative restriction endonuclease Rho_GDI PF02115.12 CCF37311.1 - 7e-42 143.1 0.1 8.3e-42 142.8 0.1 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Metallophos PF00149.23 CCF37312.1 - 3.1e-43 147.4 1.0 3.9e-43 147.1 0.7 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ABC_membrane PF00664.18 CCF37313.1 - 1.1e-35 123.3 12.3 1.5e-35 122.9 8.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 CCF37313.1 - 2.4e-34 118.5 0.0 1.3e-33 116.2 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.1 CCF37313.1 - 1.9e-06 28.0 0.1 1.8e-05 24.7 0.1 2.4 2 1 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.14 CCF37313.1 - 1.2e-05 24.6 0.0 0.0022 17.2 0.0 2.3 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF37313.1 - 2e-05 24.6 0.0 0.12 12.3 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_14 PF13173.1 CCF37313.1 - 0.00025 20.9 0.0 0.0017 18.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 CCF37313.1 - 0.00025 20.5 0.2 0.0025 17.3 0.0 2.1 1 1 0 2 2 2 1 AAA-like domain AAA_22 PF13401.1 CCF37313.1 - 0.00031 20.8 0.0 0.0015 18.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CCF37313.1 - 0.00058 20.6 0.0 0.0014 19.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 CCF37313.1 - 0.00097 18.3 0.0 0.0019 17.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 CCF37313.1 - 0.0056 16.1 0.0 0.016 14.7 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain MobB PF03205.9 CCF37313.1 - 0.0082 15.8 0.0 0.035 13.8 0.0 2.1 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 CCF37313.1 - 0.015 15.2 0.0 0.055 13.4 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_33 PF13671.1 CCF37313.1 - 0.015 15.1 0.0 0.035 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 CCF37313.1 - 0.017 15.3 0.0 0.081 13.1 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 CCF37313.1 - 0.027 13.5 0.0 0.075 12.1 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.1 CCF37313.1 - 0.03 14.6 0.0 0.11 12.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 CCF37313.1 - 0.032 13.6 0.0 0.072 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 CCF37313.1 - 0.034 14.0 0.4 0.41 10.6 0.3 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Miro PF08477.8 CCF37313.1 - 0.042 14.3 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein AAA_28 PF13521.1 CCF37313.1 - 0.043 13.7 0.0 0.097 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Tir_receptor_C PF07489.6 CCF37313.1 - 0.045 13.5 1.2 0.086 12.5 0.9 1.4 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Arch_ATPase PF01637.13 CCF37313.1 - 0.049 13.3 0.0 0.12 12.0 0.0 1.7 1 1 0 1 1 1 0 Archaeal ATPase Septin PF00735.13 CCF37313.1 - 0.07 12.1 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Septin NACHT PF05729.7 CCF37313.1 - 0.074 12.7 0.3 0.21 11.2 0.0 1.9 3 0 0 3 3 1 0 NACHT domain DUF1192 PF06698.6 CCF37314.1 - 0.092 12.5 0.5 0.16 11.7 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Sugar_tr PF00083.19 CCF37315.1 - 1.4e-86 290.9 20.2 1.6e-86 290.7 14.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF37315.1 - 4.7e-19 68.3 38.1 5.4e-13 48.3 6.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DEAD PF00270.24 CCF37316.1 - 4.3e-46 156.4 0.0 2.6e-44 150.6 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF37316.1 - 2.9e-29 100.7 0.0 7.6e-28 96.1 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF37316.1 - 2.6e-05 24.1 0.3 0.00015 21.6 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.9 CCF37316.1 - 0.00019 20.8 0.0 0.00059 19.2 0.0 1.8 1 1 0 2 2 2 1 SecA DEAD-like domain SNF2_N PF00176.18 CCF37316.1 - 0.0033 16.2 0.0 0.0057 15.4 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF1253 PF06862.7 CCF37316.1 - 0.042 12.2 0.0 0.042 12.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1253) Peptidase_S49_N PF08496.5 CCF37316.1 - 0.099 12.4 1.2 0.18 11.6 0.9 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal CMS1 PF14617.1 CCF37316.1 - 1.5 7.8 8.2 8.4 5.3 0.0 2.4 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit BLVR PF06375.6 CCF37316.1 - 2.4 7.9 10.3 4.7 7.0 7.1 1.4 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) Rft-1 PF04506.8 CCF37317.1 - 1.5e-91 307.5 7.6 1.8e-91 307.2 5.3 1.0 1 0 0 1 1 1 1 Rft protein adh_short PF00106.20 CCF37318.1 - 2.2e-14 53.7 0.7 4.3e-14 52.7 0.5 1.5 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF37318.1 - 3.8e-07 30.1 0.1 5.4e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF37318.1 - 1.4e-05 24.8 1.7 3e-05 23.7 1.2 1.6 1 1 0 1 1 1 1 KR domain DUF3425 PF11905.3 CCF37319.1 - 5.3e-27 94.3 0.2 9.9e-27 93.4 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) DnaJ PF00226.26 CCF37320.1 - 2.1e-08 33.7 0.0 5.2e-08 32.5 0.0 1.7 2 0 0 2 2 2 1 DnaJ domain MARVEL PF01284.18 CCF37321.1 - 0.00064 19.5 1.1 0.0013 18.5 0.8 1.5 1 1 0 1 1 1 1 Membrane-associating domain Peptidase_C2 PF00648.16 CCF37322.1 - 7e-12 44.9 0.0 1.2e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Calpain family cysteine protease Peptidase_C1 PF00112.18 CCF37322.1 - 0.041 13.7 0.4 0.066 13.0 0.3 1.3 1 0 0 1 1 1 0 Papain family cysteine protease DUF924 PF06041.6 CCF37323.1 - 0.081 12.6 10.3 0.09 12.5 7.2 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF924) MRP-S26 PF14943.1 CCF37323.1 - 0.42 10.1 15.3 0.48 9.9 10.6 1.0 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 FimP PF09766.4 CCF37323.1 - 0.5 9.3 27.5 0.55 9.2 19.0 1.0 1 0 0 1 1 1 0 Fms-interacting protein Spore_coat_CotO PF14153.1 CCF37323.1 - 0.57 9.5 17.4 0.61 9.5 12.1 1.0 1 0 0 1 1 1 0 Spore coat protein CotO DUF1764 PF08576.5 CCF37323.1 - 0.6 10.9 13.7 0.68 10.7 9.5 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) BRF1 PF07741.8 CCF37323.1 - 0.8 9.9 12.4 0.8 9.9 8.6 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain DUF4557 PF15101.1 CCF37323.1 - 0.94 9.2 24.5 0.93 9.3 17.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) CPSF100_C PF13299.1 CCF37323.1 - 0.95 9.6 9.3 1 9.5 6.5 1.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal eIF3_subunit PF08597.5 CCF37323.1 - 0.98 8.9 12.5 1 8.8 8.6 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Bud13 PF09736.4 CCF37323.1 - 1.1 9.5 19.3 1.1 9.4 13.4 1.0 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex ATP-synt_E PF05680.7 CCF37323.1 - 1.1 9.2 13.7 1.6 8.7 9.5 1.3 1 0 0 1 1 1 0 ATP synthase E chain DDHD PF02862.12 CCF37323.1 - 1.1 8.9 10.6 1.2 8.9 7.3 1.0 1 0 0 1 1 1 0 DDHD domain DDRGK PF09756.4 CCF37323.1 - 1.3 8.3 17.7 1.3 8.3 12.3 1.0 1 0 0 1 1 1 0 DDRGK domain AIF_C PF14721.1 CCF37323.1 - 1.4 9.2 11.3 1.5 9.0 7.9 1.0 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF3306 PF11748.3 CCF37323.1 - 1.4 9.6 12.7 1.5 9.4 8.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) PH_4 PF15404.1 CCF37323.1 - 1.5 8.2 12.2 1.7 8.1 8.4 1.0 1 0 0 1 1 1 0 Pleckstrin homology domain DUF702 PF05142.7 CCF37323.1 - 1.5 8.9 11.7 1.6 8.8 8.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Baculo_PP31 PF05311.6 CCF37323.1 - 1.5 7.9 12.4 1.6 7.9 8.6 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) FAM60A PF15396.1 CCF37323.1 - 1.6 8.4 8.2 1.6 8.4 5.7 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Trypan_glycop_C PF10659.4 CCF37323.1 - 1.7 9.0 10.0 1.9 8.8 6.9 1.2 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein C-terminal domain CagX PF03524.10 CCF37323.1 - 1.7 7.8 12.0 1.9 7.7 8.3 1.2 1 0 0 1 1 1 0 Conjugal transfer protein Peptidase_S49_N PF08496.5 CCF37323.1 - 1.9 8.2 11.7 1.9 8.2 8.1 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal BTV_NS2 PF04514.7 CCF37323.1 - 1.9 7.3 9.2 1.9 7.2 6.4 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Dala_Dala_lig_N PF01820.16 CCF37323.1 - 1.9 8.8 7.9 2.1 8.7 5.5 1.1 1 0 0 1 1 1 0 D-ala D-ala ligase N-terminus DUF4175 PF13779.1 CCF37323.1 - 1.9 6.0 39.9 1.9 6.0 27.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Paf1 PF03985.8 CCF37323.1 - 2 7.0 17.0 2.1 6.9 11.8 1.0 1 0 0 1 1 1 0 Paf1 Tim54 PF11711.3 CCF37323.1 - 2.1 6.8 8.8 2.2 6.7 6.1 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 FHIPEP PF00771.15 CCF37323.1 - 2.2 6.5 10.1 2.3 6.4 7.0 1.0 1 0 0 1 1 1 0 FHIPEP family DUF912 PF06024.7 CCF37323.1 - 2.3 8.3 10.8 2.9 8.0 7.5 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) FLO_LFY PF01698.11 CCF37323.1 - 2.4 6.9 12.8 2.6 6.8 8.9 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein SeqA PF03925.8 CCF37323.1 - 2.5 7.7 11.8 2.6 7.6 8.2 1.0 1 0 0 1 1 1 0 SeqA protein Gti1_Pac2 PF09729.4 CCF37323.1 - 2.6 7.8 10.6 2.6 7.8 7.4 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family Glyco_transf_15 PF01793.11 CCF37323.1 - 2.7 6.8 12.3 2.7 6.8 8.5 1.0 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase FAM176 PF14851.1 CCF37323.1 - 2.9 7.5 7.4 2.9 7.5 5.1 1.1 1 0 0 1 1 1 0 FAM176 family GOLD_2 PF13897.1 CCF37323.1 - 3 8.0 6.0 3.3 7.9 4.1 1.1 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking FCP1_C PF09309.5 CCF37323.1 - 3.1 7.0 16.2 4.6 6.4 11.2 1.3 1 0 0 1 1 1 0 FCP1, C-terminal PAT1 PF09770.4 CCF37323.1 - 3.1 5.9 33.3 3.1 5.9 23.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 NARP1 PF12569.3 CCF37323.1 - 3.3 6.3 13.5 3.3 6.3 9.3 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FlaG PF03646.10 CCF37323.1 - 3.3 7.8 20.4 3.9 7.6 14.1 1.1 1 0 0 1 1 1 0 FlaG protein Serinc PF03348.10 CCF37323.1 - 3.6 6.2 13.3 3.4 6.2 9.2 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) RED_N PF07808.8 CCF37323.1 - 3.6 6.7 21.6 3.9 6.6 15.0 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region ATAD4 PF15321.1 CCF37323.1 - 3.6 8.6 14.4 4.6 8.3 10.0 1.1 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 DUF329 PF03884.9 CCF37323.1 - 3.7 7.1 6.9 12 5.5 4.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF329) Band_3_cyto PF07565.8 CCF37323.1 - 3.8 6.9 15.3 4 6.8 10.6 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain AUX_IAA PF02309.11 CCF37323.1 - 3.9 7.1 10.5 4 7.1 7.3 1.0 1 0 0 1 1 1 0 AUX/IAA family DUF3464 PF11947.3 CCF37323.1 - 3.9 6.9 11.3 4.3 6.7 7.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) DUF4512 PF14975.1 CCF37323.1 - 4 8.3 8.0 4.6 8.1 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4512) HGTP_anticodon2 PF12745.2 CCF37323.1 - 4.1 6.4 12.3 4.4 6.3 8.5 1.0 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Suf PF05843.9 CCF37323.1 - 4.2 7.0 20.7 4.4 6.9 14.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Ctr PF04145.10 CCF37323.1 - 4.2 7.4 9.0 4.7 7.2 6.2 1.1 1 0 0 1 1 1 0 Ctr copper transporter family TFIIA PF03153.8 CCF37323.1 - 4.3 7.1 26.7 4.3 7.1 18.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.7 CCF37323.1 - 4.3 7.1 15.5 4.6 7.0 10.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pex14_N PF04695.8 CCF37323.1 - 4.6 7.2 22.6 5 7.1 15.6 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3276 PF11680.3 CCF37323.1 - 4.7 7.0 10.0 5.4 6.8 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) CDC45 PF02724.9 CCF37323.1 - 5.1 5.0 12.8 5 5.0 8.9 1.0 1 0 0 1 1 1 0 CDC45-like protein RIC3 PF15361.1 CCF37323.1 - 5.2 7.2 14.0 5.9 7.1 9.7 1.1 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 RCR PF12273.3 CCF37323.1 - 5.5 7.5 20.2 5.7 7.4 14.0 1.1 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Folate_carrier PF01770.13 CCF37323.1 - 5.5 5.3 9.6 5.7 5.3 6.6 1.0 1 0 0 1 1 1 0 Reduced folate carrier Pal1 PF08316.6 CCF37323.1 - 5.7 7.3 8.0 5.6 7.4 5.6 1.1 1 0 0 1 1 1 0 Pal1 cell morphology protein DUF463 PF04317.7 CCF37323.1 - 6.1 5.3 13.4 6.6 5.1 9.3 1.0 1 0 0 1 1 1 0 YcjX-like family, DUF463 Pex16 PF08610.5 CCF37323.1 - 6.2 5.7 14.1 6 5.7 9.8 1.0 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) PBP1_TM PF14812.1 CCF37323.1 - 6.8 7.0 7.0 7.6 6.9 4.9 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ARF7EP_C PF14949.1 CCF37323.1 - 6.8 7.1 12.7 7.8 6.9 8.8 1.1 1 0 0 1 1 1 0 ARF7 effector protein C-terminus DUF3381 PF11861.3 CCF37323.1 - 7.1 6.1 13.8 8 5.9 9.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) EIIBC-GUT_N PF03612.9 CCF37323.1 - 7.3 6.1 12.4 8.1 6.0 8.6 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Hid1 PF12722.2 CCF37323.1 - 7.3 4.1 15.1 7.1 4.1 10.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2347 PF09804.4 CCF37323.1 - 7.3 5.7 10.2 7.7 5.7 7.1 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Kei1 PF08552.6 CCF37323.1 - 7.3 6.1 10.3 7.7 6.1 7.1 1.0 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Peptidase_U57 PF05582.7 CCF37323.1 - 7.5 5.4 11.5 7.9 5.3 8.0 1.0 1 0 0 1 1 1 0 YabG peptidase U57 TraH_2 PF06871.6 CCF37323.1 - 7.9 5.8 7.5 8.6 5.7 5.2 1.0 1 0 0 1 1 1 0 TraH_2 DUF4518 PF15008.1 CCF37323.1 - 8 5.4 14.5 9.4 5.1 10.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) RICTOR_N PF14664.1 CCF37323.1 - 8.1 4.9 7.3 8.9 4.7 5.1 1.0 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term DUF913 PF06025.7 CCF37323.1 - 8.6 5.0 8.2 9.1 4.9 5.7 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3371 PF11851.3 CCF37323.1 - 9.3 6.9 21.4 11 6.6 14.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) DUF3260 PF11658.3 CCF37323.1 - 9.7 4.2 13.1 10 4.1 9.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) ARGLU PF15346.1 CCF37323.1 - 9.8 5.9 24.0 12 5.6 16.6 1.0 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 DUF3675 PF12428.3 CCF37323.1 - 10 6.4 9.3 11 6.2 6.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3675) DAHP_synth_1 PF00793.15 CCF37325.1 - 3.1e-98 327.7 0.1 3.7e-98 327.5 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family YIEGIA PF14045.1 CCF37325.1 - 0.075 11.6 0.2 0.13 10.8 0.1 1.3 1 0 0 1 1 1 0 YIEGIA protein PAP_PilO PF06864.7 CCF37326.1 - 0.087 11.1 0.0 0.1 10.9 0.0 1.1 1 0 0 1 1 1 0 Pilin accessory protein (PilO) Ribosomal_L50 PF10501.4 CCF37327.1 - 5e-21 74.7 0.4 9.8e-21 73.8 0.0 1.7 2 0 0 2 2 2 1 Ribosomal subunit 39S HSP70 PF00012.15 CCF37328.1 - 5.4e-230 764.4 8.1 6e-230 764.2 5.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 CCF37328.1 - 3.6e-16 58.6 0.3 3.3e-15 55.5 0.1 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 CCF37328.1 - 0.0046 16.5 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 CCF37328.1 - 0.13 12.0 1.2 14 5.5 0.1 3.5 3 1 0 3 3 3 0 Cell division protein FtsA DNA_mis_repair PF01119.14 CCF37330.1 - 2.6e-33 114.0 0.0 3.7e-33 113.4 0.0 1.2 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 CCF37330.1 - 1.5e-12 47.3 0.0 2.8e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 CCF37330.1 - 1.1e-09 37.9 0.0 2.8e-09 36.6 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Thioredoxin_8 PF13905.1 CCF37330.1 - 0.061 13.4 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like Beta-lactamase PF00144.19 CCF37331.1 - 3.1e-54 184.2 0.0 3.7e-54 183.9 0.0 1.0 1 0 0 1 1 1 1 Beta-lactamase Cu-oxidase_3 PF07732.10 CCF37333.1 - 4.1e-50 168.4 5.1 5.5e-47 158.3 0.8 2.3 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.17 CCF37333.1 - 1.9e-28 99.3 0.1 2.1e-27 95.9 0.0 2.4 3 0 0 3 3 3 1 Multicopper oxidase DUF1183 PF06682.7 CCF37333.1 - 0.021 14.4 0.0 0.037 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) FAD_binding_4 PF01565.18 CCF37334.1 - 1.1e-18 67.0 1.8 2.5e-18 65.9 1.2 1.6 1 0 0 1 1 1 1 FAD binding domain DUF1914 PF08932.5 CCF37334.1 - 0.014 15.4 0.0 0.036 14.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1914) BBE PF08031.7 CCF37334.1 - 0.058 13.3 0.3 0.2 11.5 0.2 1.9 2 0 0 2 2 2 0 Berberine and berberine like MMR_HSR1 PF01926.18 CCF37335.1 - 2.3e-11 43.6 0.0 3.7e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CCF37335.1 - 0.0017 17.6 0.1 0.0038 16.5 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B DUF258 PF03193.11 CCF37335.1 - 0.0045 16.2 0.3 0.012 14.7 0.2 1.7 1 1 0 1 1 1 1 Protein of unknown function, DUF258 ArgK PF03308.11 CCF37335.1 - 0.0077 15.0 0.1 0.012 14.3 0.1 1.3 1 0 0 1 1 1 1 ArgK protein AAA_17 PF13207.1 CCF37335.1 - 0.021 15.6 0.2 0.24 12.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain Arf PF00025.16 CCF37335.1 - 0.037 13.2 0.0 0.062 12.5 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_16 PF13191.1 CCF37335.1 - 0.046 13.7 0.1 0.14 12.0 0.1 1.8 1 1 0 2 2 2 0 AAA ATPase domain MobB PF03205.9 CCF37335.1 - 0.075 12.7 0.1 0.22 11.2 0.0 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 CCF37335.1 - 0.076 13.3 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain PHD PF00628.24 CCF37336.1 - 7.6e-10 38.3 1.9 1.7e-09 37.2 1.3 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.1 CCF37336.1 - 0.0019 17.4 3.4 0.0032 16.7 2.3 1.4 1 0 0 1 1 1 1 PHD-finger UIM PF02809.15 CCF37336.1 - 0.0033 16.8 1.2 0.01 15.2 0.8 1.9 1 0 0 1 1 1 1 Ubiquitin interaction motif SNF2_N PF00176.18 CCF37337.1 - 9.6e-61 205.1 0.1 1.9e-60 204.1 0.0 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CCF37337.1 - 8.4e-15 54.3 0.1 2.7e-14 52.7 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain UBA PF00627.26 CCF37337.1 - 8.7e-05 22.2 0.1 0.00024 20.8 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain VMA21 PF09446.5 CCF37338.1 - 5.8e-16 58.1 8.8 8e-16 57.7 6.1 1.2 1 0 0 1 1 1 1 VMA21-like domain bZIP_1 PF00170.16 CCF37339.1 - 1.2e-05 25.1 13.9 0.00078 19.3 0.5 3.3 3 0 0 3 3 3 1 bZIP transcription factor TMF_DNA_bd PF12329.3 CCF37339.1 - 0.00058 19.6 13.5 0.035 13.9 2.0 3.2 2 1 1 3 3 3 2 TATA element modulatory factor 1 DNA binding DUF904 PF06005.7 CCF37339.1 - 0.00063 19.9 13.1 1.1 9.6 6.3 3.2 2 1 0 2 2 2 1 Protein of unknown function (DUF904) AAA_27 PF13514.1 CCF37339.1 - 0.00089 17.0 15.7 0.0011 16.7 10.9 1.0 1 0 0 1 1 1 1 AAA domain MscS_porin PF12795.2 CCF37339.1 - 0.0011 18.3 12.4 0.0011 18.3 8.6 1.6 1 1 0 2 2 2 1 Mechanosensitive ion channel porin domain Spc7 PF08317.6 CCF37339.1 - 0.0013 17.4 8.4 0.0013 17.4 5.8 1.4 1 1 0 1 1 1 1 Spc7 kinetochore protein Bacillus_HBL PF05791.6 CCF37339.1 - 0.0018 17.7 4.3 0.11 11.8 0.1 2.3 1 1 1 2 2 2 1 Bacillus haemolytic enterotoxin (HBL) AKNA PF12443.3 CCF37339.1 - 0.0024 17.8 6.7 0.054 13.5 1.8 2.4 1 1 1 2 2 2 1 AT-hook-containing transcription factor TPR_MLP1_2 PF07926.7 CCF37339.1 - 0.0025 17.5 14.6 0.026 14.2 3.1 3.0 2 1 1 3 3 3 1 TPR/MLP1/MLP2-like protein DUF812 PF05667.6 CCF37339.1 - 0.021 13.3 11.3 0.031 12.8 7.8 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DUF1192 PF06698.6 CCF37339.1 - 0.022 14.5 7.1 4.8 7.0 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) DUF869 PF05911.6 CCF37339.1 - 0.022 13.0 14.1 0.09 10.9 2.8 2.0 1 1 1 2 2 2 0 Plant protein of unknown function (DUF869) ATG16 PF08614.6 CCF37339.1 - 0.023 14.5 16.6 0.039 13.7 7.2 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Shugoshin_N PF07558.6 CCF37339.1 - 0.03 14.0 3.1 0.033 13.9 0.5 2.3 2 0 0 2 2 1 0 Shugoshin N-terminal coiled-coil region EzrA PF06160.7 CCF37339.1 - 0.031 12.4 13.2 0.032 12.4 8.1 1.8 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Fib_alpha PF08702.5 CCF37339.1 - 0.033 14.2 7.8 0.015 15.4 3.4 1.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family LMP PF04778.7 CCF37339.1 - 0.04 13.6 3.2 0.14 11.9 2.1 1.9 1 1 0 1 1 1 0 LMP repeated region NPV_P10 PF05531.7 CCF37339.1 - 0.051 13.8 3.1 0.2 11.9 0.1 2.6 3 0 0 3 3 2 0 Nucleopolyhedrovirus P10 protein DUF4200 PF13863.1 CCF37339.1 - 0.092 12.7 14.6 1 9.3 0.6 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) HrpB7 PF09486.5 CCF37339.1 - 0.11 12.4 15.2 0.2 11.5 10.5 1.6 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) GAS PF13851.1 CCF37339.1 - 0.12 11.5 10.5 0.18 10.9 1.4 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding SAPS PF04499.10 CCF37339.1 - 0.14 10.7 5.8 0.17 10.4 4.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein TSC22 PF01166.13 CCF37339.1 - 0.14 12.1 6.0 15 5.6 0.0 3.4 3 1 0 3 3 3 0 TSC-22/dip/bun family DUF1875 PF08961.5 CCF37339.1 - 0.14 11.4 7.3 0.17 11.2 1.2 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF1875) Chordopox_G3 PF06129.7 CCF37339.1 - 0.15 12.1 0.3 0.26 11.4 0.2 1.4 1 0 0 1 1 1 0 Chordopoxvirus G3 protein Filament PF00038.16 CCF37339.1 - 0.15 11.4 13.6 0.23 10.8 6.9 1.9 1 1 1 2 2 2 0 Intermediate filament protein Bap31 PF05529.7 CCF37339.1 - 0.22 10.9 8.8 1.5 8.1 2.0 2.1 1 1 1 2 2 2 0 B-cell receptor-associated protein 31-like MCC-bdg_PDZ PF10506.4 CCF37339.1 - 0.22 11.3 12.9 0.56 10.0 0.4 3.3 1 1 3 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Sigma54_AID PF00309.15 CCF37339.1 - 0.24 10.9 0.3 0.24 10.9 0.2 2.6 3 0 0 3 3 2 0 Sigma-54 factor, Activator interacting domain (AID) DUF641 PF04859.7 CCF37339.1 - 0.26 11.0 9.3 1 9.1 3.4 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Poty_PP PF08440.5 CCF37339.1 - 0.28 10.2 4.7 0.4 9.7 3.2 1.2 1 0 0 1 1 1 0 Potyviridae polyprotein Reo_sigmaC PF04582.7 CCF37339.1 - 0.34 10.0 2.3 4.1 6.4 0.4 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein ADIP PF11559.3 CCF37339.1 - 0.35 10.7 17.5 0.53 10.1 1.8 2.7 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.1 CCF37339.1 - 0.36 9.7 10.5 0.52 9.2 7.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMCO5 PF14992.1 CCF37339.1 - 0.44 9.6 7.1 1.4 7.9 0.4 1.9 1 1 1 2 2 2 0 TMCO5 family DUF4618 PF15397.1 CCF37339.1 - 0.45 9.7 13.0 1.3 8.2 3.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) HAUS-augmin3 PF14932.1 CCF37339.1 - 0.55 9.3 13.1 0.22 10.6 4.0 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 IFT20 PF14931.1 CCF37339.1 - 0.67 9.8 12.8 2.6 7.9 7.4 2.2 1 1 1 2 2 2 0 Intraflagellar transport complex B, subunit 20 IncA PF04156.9 CCF37339.1 - 0.68 9.5 19.9 2.1 7.9 13.8 1.8 1 1 0 1 1 1 0 IncA protein DUF724 PF05266.9 CCF37339.1 - 0.68 9.5 11.1 0.91 9.1 2.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Fmp27_WPPW PF10359.4 CCF37339.1 - 0.88 7.9 14.5 0.27 9.5 2.1 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain APG6 PF04111.7 CCF37339.1 - 1.1 8.2 13.4 1.5 7.8 9.3 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Halogen_Hydrol PF10112.4 CCF37339.1 - 1.3 8.3 4.9 1.3 8.3 0.8 2.1 1 1 1 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Herpes_BLRF2 PF05812.7 CCF37339.1 - 1.3 8.8 7.7 0.82 9.4 0.7 2.8 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein PEP-utilisers_N PF05524.8 CCF37339.1 - 1.5 8.6 11.6 3 7.6 1.9 2.6 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal Cut12 PF11500.3 CCF37339.1 - 1.8 8.2 8.2 28 4.3 5.7 2.6 1 1 0 1 1 1 0 Spindle pole body formation-associated protein DUF4613 PF15390.1 CCF37339.1 - 2.2 6.3 7.7 2.6 6.1 5.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) Uds1 PF15456.1 CCF37339.1 - 2.7 8.0 17.1 0.72 9.8 7.1 2.2 1 1 1 2 2 2 0 Up-regulated During Septation DUF1664 PF07889.7 CCF37339.1 - 3.1 7.6 5.7 4.9 6.9 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DivIC PF04977.10 CCF37339.1 - 3.3 7.2 16.9 2.9 7.4 0.3 3.9 2 1 2 4 4 4 0 Septum formation initiator Prefoldin PF02996.12 CCF37339.1 - 3.4 7.3 7.1 1.8 8.2 0.3 2.7 3 0 0 3 3 2 0 Prefoldin subunit TMPIT PF07851.8 CCF37339.1 - 3.5 6.6 5.6 3.4 6.6 3.3 1.3 1 1 0 1 1 1 0 TMPIT-like protein DUF972 PF06156.8 CCF37339.1 - 4 7.8 12.6 4.1 7.7 2.9 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF972) GrpE PF01025.14 CCF37339.1 - 4.4 6.8 12.2 2.5 7.5 3.8 2.4 1 1 1 2 2 2 0 GrpE Viral_P18 PF04521.8 CCF37339.1 - 5 6.5 10.4 2.9 7.3 0.4 3.1 1 1 3 4 4 4 0 ssRNA positive strand viral 18kD cysteine rich protein V_ATPase_I PF01496.14 CCF37339.1 - 5.1 4.8 5.9 6.3 4.5 4.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4349 PF14257.1 CCF37339.1 - 6.7 5.8 17.0 4.7 6.3 2.1 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF4349) Nup54 PF13874.1 CCF37339.1 - 6.9 6.3 15.5 2.4 7.8 5.8 2.9 1 1 0 2 2 2 0 Nucleoporin complex subunit 54 DUF2968 PF11180.3 CCF37339.1 - 7 5.9 19.4 1.8 7.8 9.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) bZIP_Maf PF03131.12 CCF37339.1 - 7.2 6.9 14.8 3 8.2 2.5 3.2 1 1 1 2 2 2 0 bZIP Maf transcription factor Myb_DNA-bind_6 PF13921.1 CCF37340.1 - 2e-15 56.6 0.1 8.8e-08 32.1 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 CCF37340.1 - 7.8e-12 45.0 0.2 0.0001 22.2 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Cyclin_N PF00134.18 CCF37342.1 - 7.4e-44 148.3 0.0 2.9e-43 146.4 0.0 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 CCF37342.1 - 5.2e-33 113.4 0.0 8.8e-33 112.7 0.0 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain Polysacc_deac_1 PF01522.16 CCF37343.1 - 5.1e-28 97.1 0.0 9.5e-28 96.3 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.14 CCF37343.1 - 0.00015 21.7 17.9 0.00015 21.7 12.4 2.1 2 0 0 2 2 2 1 Chitin recognition protein PAP2 PF01569.16 CCF37344.1 - 1.5e-20 73.2 1.7 1.5e-20 73.2 1.2 2.2 2 0 0 2 2 2 1 PAP2 superfamily CK_II_beta PF01214.13 CCF37345.1 - 6.8e-73 244.0 0.2 8.5e-73 243.7 0.1 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Abhydrolase_6 PF12697.2 CCF37346.1 - 8.2e-22 78.1 0.4 1.1e-21 77.8 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF37346.1 - 5.5e-12 45.6 0.4 8e-12 45.1 0.3 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF37346.1 - 5.9e-06 26.0 0.0 0.013 15.0 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_8 PF06259.7 CCF37346.1 - 0.0027 17.2 0.7 0.0042 16.5 0.5 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase PGAP1 PF07819.8 CCF37346.1 - 0.082 12.4 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein DNA_pol3_tau_5 PF12170.3 CCF37346.1 - 0.1 12.5 0.0 7.9 6.4 0.0 2.2 2 0 0 2 2 2 0 DNA polymerase III tau subunit V interacting with alpha Thioesterase PF00975.15 CCF37346.1 - 0.13 12.4 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain NPP1 PF05630.6 CCF37348.1 - 2.5e-67 226.6 0.0 2.9e-67 226.4 0.0 1.0 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) MFS_1 PF07690.11 CCF37349.1 - 1.6e-15 56.7 18.4 1.6e-15 56.7 12.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.11 CCF37349.1 - 1.1e-06 28.2 2.2 1.1e-06 28.2 1.5 2.2 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 TauD PF02668.11 CCF37350.1 - 1.7e-20 73.7 0.6 3e-19 69.6 0.4 2.0 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CRIC_ras_sig PF10534.4 CCF37350.1 - 0.028 14.4 0.0 0.063 13.3 0.0 1.5 1 0 0 1 1 1 0 Connector enhancer of kinase suppressor of ras MFS_1 PF07690.11 CCF37351.1 - 6.4e-27 94.1 19.6 9.9e-27 93.5 13.6 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Gly-zipper_Omp PF13488.1 CCF37351.1 - 1.4 8.6 6.7 16 5.2 1.2 3.1 2 1 0 2 2 2 0 Glycine zipper Rick_17kDa_Anti PF05433.10 CCF37351.1 - 1.6 8.4 10.8 4.9 6.8 2.5 2.8 2 0 0 2 2 2 0 Glycine zipper 2TM domain Trehalose_recp PF06151.8 CCF37352.1 - 0.00081 17.8 0.3 0.0011 17.3 0.2 1.2 1 0 0 1 1 1 1 Trehalose receptor TPR_11 PF13414.1 CCF37353.1 - 1.5e-10 40.6 0.1 3.5e-09 36.1 0.0 2.5 3 0 0 3 3 3 1 TPR repeat TPR_2 PF07719.12 CCF37353.1 - 9.4e-07 28.2 0.0 0.38 10.7 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 CCF37353.1 - 2.4e-05 23.7 0.0 0.04 13.5 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 CCF37353.1 - 0.00062 19.6 0.1 0.017 15.0 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat DnaJ PF00226.26 CCF37353.1 - 0.0011 18.6 0.0 0.0035 17.0 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain TPR_16 PF13432.1 CCF37353.1 - 0.0037 17.8 3.3 0.013 16.1 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat UQ_con PF00179.21 CCF37354.1 - 5.1e-51 171.7 0.0 5.8e-51 171.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Glyco_hydro_3 PF00933.16 CCF37356.1 - 4.4e-69 232.7 0.0 6.2e-69 232.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 CCF37356.1 - 3.4e-58 196.8 0.0 5.1e-58 196.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 CCF37356.1 - 4.9e-23 80.8 0.3 1.1e-22 79.7 0.2 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF11 PF01345.13 CCF37356.1 - 0.0074 16.3 2.4 0.023 14.7 1.7 1.9 1 0 0 1 1 1 1 Domain of unknown function DUF11 HAD_2 PF13419.1 CCF37357.1 - 1.6e-31 109.9 0.0 1.9e-31 109.6 0.0 1.0 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CCF37357.1 - 0.035 13.8 0.0 0.064 12.9 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like Hydrolase PF00702.21 CCF37357.1 - 0.05 14.0 0.0 0.12 12.7 0.0 1.7 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase HAD PF12710.2 CCF37357.1 - 0.096 12.8 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF3321 PF11968.3 CCF37358.1 - 2.2e-82 275.9 0.0 2.9e-82 275.5 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase (DUF3321) Methyltransf_23 PF13489.1 CCF37358.1 - 0.00016 21.4 0.0 0.00034 20.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Phage_cap_E PF03864.10 CCF37358.1 - 0.039 12.8 0.0 0.057 12.3 0.0 1.2 1 0 0 1 1 1 0 Phage major capsid protein E WW PF00397.21 CCF37359.1 - 3.6e-08 33.1 4.2 6.6e-08 32.2 2.9 1.5 1 0 0 1 1 1 1 WW domain DUF2076 PF09849.4 CCF37359.1 - 0.00018 21.6 17.7 0.00018 21.6 12.3 2.8 3 1 0 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2076) Gly-zipper_OmpA PF13436.1 CCF37359.1 - 0.15 11.7 7.5 0.054 13.1 2.6 2.2 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain MFS_1 PF07690.11 CCF37360.1 - 2.9e-23 82.1 23.9 1e-22 80.3 16.6 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF37360.1 - 3.9e-15 55.3 9.4 5.1e-15 54.9 6.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 CCF37360.1 - 4.6e-05 21.8 2.6 6.8e-05 21.2 1.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.15 CCF37360.1 - 0.19 9.7 1.7 0.34 8.8 0.1 2.0 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family HTH_psq PF05225.11 CCF37361.1 - 3.8e-15 55.1 0.3 9.7e-15 53.8 0.2 1.7 2 0 0 2 2 2 1 helix-turn-helix, Psq domain HTH_23 PF13384.1 CCF37361.1 - 3.6e-05 23.2 0.3 8.9e-05 22.0 0.0 1.8 2 1 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 CCF37361.1 - 0.00017 21.5 0.1 0.00039 20.3 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_7 PF02796.10 CCF37361.1 - 0.0003 20.5 0.1 0.00057 19.6 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.1 CCF37361.1 - 0.00093 18.7 0.2 0.0025 17.3 0.0 1.8 2 1 0 2 2 2 1 PucR C-terminal helix-turn-helix domain HTH_1 PF00126.22 CCF37361.1 - 0.0025 17.5 1.4 0.023 14.4 0.2 2.5 2 1 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family SpoIIID PF12116.3 CCF37361.1 - 0.025 14.5 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 Stage III sporulation protein D CENP-B_N PF04218.8 CCF37361.1 - 0.033 13.5 0.0 0.057 12.8 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_8 PF02954.14 CCF37361.1 - 0.042 13.3 2.7 0.28 10.7 0.1 3.0 2 2 1 3 3 3 0 Bacterial regulatory protein, Fis family DUF4164 PF13747.1 CCF37361.1 - 0.086 12.9 0.2 0.13 12.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) HTH_Tnp_1 PF01527.15 CCF37361.1 - 0.11 12.5 0.1 0.14 12.1 0.1 1.3 1 0 0 1 1 1 0 Transposase OPT PF03169.10 CCF37362.1 - 2.2e-38 132.0 7.2 2.6e-38 131.9 5.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein ADH_zinc_N_2 PF13602.1 CCF37363.1 - 2.7e-13 50.9 0.0 6.9e-13 49.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 CCF37363.1 - 7.4e-09 35.2 0.0 1.3e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF37363.1 - 2.2e-07 30.5 0.2 6.7e-07 29.0 0.0 1.9 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain Epimerase PF01370.16 CCF37363.1 - 0.015 14.7 0.0 0.021 14.2 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF37363.1 - 0.031 14.2 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 NADH(P)-binding Abhydrolase_1 PF00561.15 CCF37364.1 - 0.00011 21.7 0.0 0.00089 18.8 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Glyco_trans_1_2 PF13524.1 CCF37364.1 - 0.012 15.8 0.0 0.037 14.2 0.0 1.7 2 0 0 2 2 2 0 Glycosyl transferases group 1 Abhydrolase_6 PF12697.2 CCF37364.1 - 0.017 14.9 0.1 0.048 13.5 0.1 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_8 PF06259.7 CCF37364.1 - 0.085 12.3 0.0 0.19 11.1 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase Metallophos PF00149.23 CCF37365.1 - 3.1e-37 127.9 0.0 3.6e-32 111.3 0.0 2.1 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase DUF866 PF05907.8 CCF37366.1 - 5.8e-50 168.9 0.1 6.3e-50 168.8 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) PHD PF00628.24 CCF37366.1 - 0.061 13.0 0.6 0.14 11.8 0.4 1.6 1 0 0 1 1 1 0 PHD-finger Cas_CXXC_CXXC PF09706.5 CCF37366.1 - 0.11 12.6 1.5 0.18 12.0 0.8 1.6 1 1 0 1 1 1 0 CRISPR-associated protein (Cas_CXXC_CXXC) Lar_restr_allev PF14354.1 CCF37366.1 - 0.17 12.2 1.3 2.3 8.5 0.0 2.2 1 1 1 2 2 2 0 Restriction alleviation protein Lar DUF3716 PF12511.3 CCF37366.1 - 0.83 9.3 5.0 1.7 8.2 3.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3716) zinc_ribbon_5 PF13719.1 CCF37366.1 - 3 7.4 5.4 2.4 7.8 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 CCF37366.1 - 4.7 6.9 6.0 3.6 7.3 0.5 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Glyco_hydro_61 PF03443.9 CCF37367.1 - 3.5e-50 170.8 0.6 4.8e-50 170.3 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 p450 PF00067.17 CCF37368.1 - 7.2e-58 196.2 0.0 8.7e-58 195.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 O-FucT PF10250.4 CCF37369.1 - 2.6e-07 30.0 0.0 0.00027 20.1 0.0 3.0 2 1 0 2 2 2 2 GDP-fucose protein O-fucosyltransferase HTH_Tnp_Tc5 PF03221.11 CCF37371.1 - 1.2e-14 53.8 0.2 5.6e-13 48.4 0.0 2.5 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF37371.1 - 6.1e-12 44.9 0.1 1e-11 44.1 0.1 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_28 PF13518.1 CCF37371.1 - 0.0007 19.5 0.2 0.003 17.5 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 CCF37371.1 - 0.00085 18.8 0.5 0.003 17.1 0.0 2.1 3 0 0 3 3 3 1 Homeodomain-like domain CENP-B_N PF04218.8 CCF37371.1 - 0.017 14.5 0.0 0.031 13.7 0.0 1.3 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_29 PF13551.1 CCF37371.1 - 0.068 13.3 1.1 0.2 11.7 0.4 2.1 1 1 0 1 1 1 0 Winged helix-turn helix DUF2087 PF09860.4 CCF37371.1 - 0.08 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) G-patch PF01585.18 CCF37373.1 - 3.9e-16 58.5 2.0 9.6e-16 57.3 1.4 1.7 1 0 0 1 1 1 1 G-patch domain TIP_N PF12457.3 CCF37373.1 - 7.5e-12 45.2 16.8 7.5e-12 45.2 11.7 3.4 2 2 0 2 2 2 1 Tuftelin interacting protein N terminal G-patch_2 PF12656.2 CCF37373.1 - 1.6e-08 34.3 1.2 1.6e-08 34.3 0.8 3.5 2 2 1 3 3 3 1 DExH-box splicing factor binding site DUF4432 PF14486.1 CCF37373.1 - 0.015 13.9 0.1 0.024 13.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4432) GCFC PF07842.7 CCF37373.1 - 0.081 12.2 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 GC-rich sequence DNA-binding factor-like protein SDA1 PF05285.7 CCF37373.1 - 0.11 11.7 16.3 0.4 9.9 4.3 2.5 2 1 0 2 2 2 0 SDA1 Troponin PF00992.15 CCF37373.1 - 0.17 11.9 14.7 3 7.9 0.1 2.6 3 0 0 3 3 3 0 Troponin Tim54 PF11711.3 CCF37373.1 - 2.1 6.8 9.1 0.14 10.7 0.8 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Nop14 PF04147.7 CCF37373.1 - 9 4.0 26.9 0.61 7.9 8.0 2.1 2 0 0 2 2 2 0 Nop14-like family Epimerase PF01370.16 CCF37374.1 - 3.5e-16 59.3 0.1 5e-16 58.8 0.1 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF37374.1 - 5.5e-13 48.2 0.0 9.3e-13 47.5 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 CCF37374.1 - 9.1e-13 48.6 0.1 1.5e-12 47.8 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF37374.1 - 3.2e-09 36.3 0.1 5e-09 35.7 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.7 CCF37374.1 - 3.6e-09 35.9 0.5 3.8e-07 29.2 0.3 2.2 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.10 CCF37374.1 - 7.9e-05 21.6 0.0 0.00013 21.0 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 CCF37374.1 - 0.0025 17.7 0.2 0.01 15.7 0.1 2.0 1 1 0 1 1 1 1 short chain dehydrogenase FAD_binding_4 PF01565.18 CCF37375.1 - 1.1e-05 24.9 0.1 1.7e-05 24.3 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain DUF3176 PF11374.3 CCF37376.1 - 7.9e-27 93.3 3.0 1.7e-26 92.2 2.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) Pex14_N PF04695.8 CCF37376.1 - 0.69 9.9 4.1 0.38 10.7 0.5 2.3 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DoxX_2 PF13564.1 CCF37376.1 - 1.9 8.4 13.3 0.03 14.2 2.5 2.6 2 1 1 3 3 3 0 DoxX-like family Trypan_PARP PF05887.6 CCF37376.1 - 8.4 6.2 7.0 0.38 10.5 0.7 1.8 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) PIG-F PF06699.6 CCF37377.1 - 4.3e-54 183.3 3.3 5.3e-54 183.0 2.3 1.0 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F SNARE_assoc PF09335.6 CCF37377.1 - 0.33 11.1 7.4 0.04 14.1 1.4 2.1 3 0 0 3 3 3 0 SNARE associated Golgi protein PsbI PF02532.9 CCF37377.1 - 0.42 10.2 3.9 0.78 9.4 0.0 2.8 3 0 0 3 3 3 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) Bacteriocin_IIc PF10439.4 CCF37377.1 - 1.1 9.4 6.7 0.89 9.7 1.5 2.2 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide Pmp3 PF01679.12 CCF37378.1 - 4.9e-27 93.3 5.5 5.4e-27 93.2 3.8 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator TM_helix PF05552.7 CCF37378.1 - 0.065 12.9 2.4 0.065 12.9 1.7 1.7 2 0 0 2 2 2 0 Conserved TM helix Zn_clus PF00172.13 CCF37379.1 - 1.2e-10 41.1 10.4 1.9e-10 40.4 7.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF37379.1 - 3.1e-10 39.3 1.9 6.4e-10 38.3 1.3 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_88 PF07470.8 CCF37380.1 - 1.9e-35 122.5 3.3 2.5e-35 122.1 2.3 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Ribosomal_S19e PF01090.14 CCF37380.1 - 0.15 11.4 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S19e MBOAT_2 PF13813.1 CCF37381.1 - 4.2e-16 58.7 7.7 7.5e-16 57.9 4.2 2.2 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Mak16 PF04874.9 CCF37382.1 - 8e-21 74.0 30.4 8e-21 74.0 21.1 3.5 2 2 0 2 2 2 1 Mak16 protein C-terminal region Ribosomal_L28e PF01778.12 CCF37382.1 - 1.5e-08 35.0 0.0 3.5e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Ribosomal L28e protein family TFIIF_alpha PF05793.7 CCF37382.1 - 2.9e-06 25.9 30.4 3.5e-06 25.6 21.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) TFIIA PF03153.8 CCF37382.1 - 0.012 15.5 16.9 0.016 15.1 11.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.7 CCF37382.1 - 0.26 9.1 38.7 0.35 8.7 26.8 1.2 1 0 0 1 1 1 0 Nop14-like family PPP4R2 PF09184.6 CCF37382.1 - 2.4 7.6 23.2 3.5 7.1 16.1 1.3 1 0 0 1 1 1 0 PPP4R2 Trypan_PARP PF05887.6 CCF37382.1 - 2.8 7.7 18.2 5.4 6.8 12.6 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Mso1_Sec1_bdg PF14475.1 CCF37383.1 - 4.1e-20 70.8 0.0 7.1e-20 70.1 0.0 1.3 1 0 0 1 1 1 1 Sec1-binding region of Mso1 DUF3548 PF12068.3 CCF37384.1 - 8.1e-11 41.6 0.0 2.6e-05 23.6 0.0 3.5 3 1 0 3 3 3 3 Domain of unknown function (DUF3548) PLA2_B PF01735.13 CCF37386.1 - 2.9e-84 283.0 0.3 7.7e-84 281.6 0.2 1.6 1 1 0 1 1 1 1 Lysophospholipase catalytic domain ketoacyl-synt PF00109.21 CCF37388.1 - 2.7e-71 240.0 0.6 1.6e-70 237.4 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 CCF37388.1 - 3.9e-38 129.9 0.1 1e-37 128.6 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.16 CCF37388.1 - 4.1e-28 98.6 0.2 6.9e-28 97.8 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain Thiolase_N PF00108.18 CCF37388.1 - 0.0021 17.0 0.1 0.023 13.7 0.0 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 CCF37388.1 - 0.037 13.6 1.2 0.35 10.5 0.8 2.4 1 1 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Glyco_hydr_30_2 PF14587.1 CCF37389.1 - 9.5e-17 60.9 0.5 9.5e-17 60.9 0.3 2.1 3 0 0 3 3 3 1 O-Glycosyl hydrolase family 30 CTD PF12815.2 CCF37390.1 - 1.8e-26 92.9 56.3 3e-19 69.6 24.9 4.2 1 1 2 3 3 3 2 Spt5 C-terminal nonapeptide repeat binding Spt4 KOW PF00467.24 CCF37390.1 - 0.088 12.5 0.4 0.088 12.5 0.3 3.7 4 0 0 4 4 4 0 KOW motif Oxidored_molyb PF00174.14 CCF37391.1 - 1.9e-55 186.8 0.0 2.8e-55 186.3 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.11 CCF37391.1 - 7e-28 96.8 0.1 1.3e-27 95.9 0.1 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Cyt-b5 PF00173.23 CCF37391.1 - 8.4e-13 47.9 0.1 1.5e-12 47.1 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Transaldolase PF00923.14 CCF37393.1 - 2.2e-33 115.6 0.0 2.6e-33 115.3 0.0 1.0 1 0 0 1 1 1 1 Transaldolase WbqC PF08889.6 CCF37393.1 - 0.0011 18.4 0.0 0.0022 17.5 0.0 1.4 1 1 0 1 1 1 1 WbqC-like protein family NUDIX PF00293.23 CCF37394.1 - 2.7e-20 72.4 0.1 3.2e-20 72.1 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain MFS_1 PF07690.11 CCF37395.1 - 7.5e-43 146.5 31.7 5.6e-41 140.4 7.9 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Crust_neurohorm PF01147.12 CCF37396.1 - 0.016 14.4 3.5 0.023 14.0 2.4 1.2 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family C1_1 PF00130.17 CCF37396.1 - 1.9 8.2 5.4 4 7.2 3.7 1.6 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Methyltransf_23 PF13489.1 CCF37398.1 - 0.063 13.0 0.0 0.063 13.0 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain zf-met PF12874.2 CCF37399.1 - 6.6e-06 26.1 1.0 1.4e-05 25.1 0.7 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.4 CCF37399.1 - 0.00047 19.7 0.3 0.0007 19.1 0.2 1.2 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein PRP4 PF08799.6 CCF37399.1 - 0.053 12.8 0.9 0.095 11.9 0.6 1.4 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like MMS19_N PF14500.1 CCF37402.1 - 8.6e-53 179.2 0.0 2e-52 178.0 0.0 1.6 1 0 0 1 1 1 1 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.3 CCF37402.1 - 2.1e-12 46.5 0.4 2.1e-05 23.4 0.0 3.7 3 0 0 3 3 3 3 RNAPII transcription regulator C-terminal Sugar_tr PF00083.19 CCF37403.1 - 7.2e-10 38.0 0.9 8.8e-10 37.7 0.2 1.4 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF37403.1 - 0.00031 19.5 6.1 0.00049 18.9 4.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Epimerase PF01370.16 CCF37404.1 - 5.7e-15 55.4 0.0 1.2e-14 54.3 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF37404.1 - 1.1e-13 50.5 0.0 5.6e-13 48.2 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 CCF37404.1 - 1.1e-09 37.6 0.0 2.1e-07 30.1 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.1 CCF37404.1 - 9.6e-05 22.4 0.0 0.0009 19.2 0.0 2.3 2 1 0 2 2 2 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 CCF37404.1 - 0.001 18.0 0.0 0.004 16.0 0.0 1.9 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.20 CCF37404.1 - 0.012 15.5 0.4 0.11 12.4 0.3 2.4 1 1 0 1 1 1 0 short chain dehydrogenase NmrA PF05368.8 CCF37404.1 - 0.05 12.8 0.0 0.069 12.4 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family Oxidored_FMN PF00724.15 CCF37405.1 - 1.4e-23 83.4 0.0 1.7e-23 83.1 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Fungal_trans PF04082.13 CCF37406.1 - 1.1e-23 83.4 0.0 1.6e-23 82.9 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF37406.1 - 4.9e-06 26.3 8.1 4.9e-06 26.3 5.6 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Shisa PF13908.1 CCF37406.1 - 0.028 14.6 1.5 0.052 13.7 1.1 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator MDM1 PF15501.1 CCF37406.1 - 0.039 12.8 5.8 0.057 12.3 4.0 1.1 1 0 0 1 1 1 0 Nuclear protein MDM1 ORC6 PF05460.8 CCF37406.1 - 0.25 10.4 2.6 0.4 9.7 1.8 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) BC10 PF06726.7 CCF37408.1 - 7.4e-18 64.3 11.4 1.2e-17 63.6 7.9 1.3 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 DUF4242 PF14026.1 CCF37408.1 - 0.079 13.0 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4242) ECM11 PF15463.1 CCF37409.1 - 1.8e-41 141.7 4.3 1.8e-41 141.7 3.0 1.9 2 1 0 2 2 2 1 Extracellular mutant protein 11 DUF2762 PF10960.3 CCF37409.1 - 0.29 10.8 2.6 0.64 9.7 1.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2762) AAA_17 PF13207.1 CCF37410.1 - 1.7e-06 28.8 0.1 6.3e-06 27.0 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CCF37410.1 - 3.6e-06 27.3 0.2 4e-05 23.9 0.0 2.2 2 1 0 2 2 2 1 AAA domain SRP54 PF00448.17 CCF37410.1 - 3.2e-05 23.4 0.0 4.9e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain ArgK PF03308.11 CCF37410.1 - 0.00015 20.6 0.0 0.00024 19.9 0.0 1.2 1 0 0 1 1 1 1 ArgK protein MobB PF03205.9 CCF37410.1 - 0.0014 18.2 0.0 0.0025 17.5 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.7 CCF37410.1 - 0.0019 17.8 0.0 0.0034 17.0 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA PF00004.24 CCF37410.1 - 0.0032 17.6 0.0 0.0053 16.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PRK PF00485.13 CCF37410.1 - 0.0032 17.0 0.0 0.019 14.5 0.0 1.9 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family KAP_NTPase PF07693.9 CCF37410.1 - 0.004 16.1 0.0 0.0065 15.5 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain Zeta_toxin PF06414.7 CCF37410.1 - 0.0043 16.1 0.0 0.0068 15.5 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin NTPase_1 PF03266.10 CCF37410.1 - 0.0049 16.5 0.1 0.0077 15.9 0.1 1.3 1 0 0 1 1 1 1 NTPase ArsA_ATPase PF02374.10 CCF37410.1 - 0.0049 15.9 0.2 0.0087 15.1 0.1 1.3 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_14 PF13173.1 CCF37410.1 - 0.0056 16.5 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF37410.1 - 0.0088 16.0 0.1 0.012 15.5 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain Thymidylate_kin PF02223.12 CCF37410.1 - 0.0088 15.4 0.1 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Thymidylate kinase CbiA PF01656.18 CCF37410.1 - 0.011 15.1 0.4 0.013 14.9 0.3 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain IstB_IS21 PF01695.12 CCF37410.1 - 0.014 14.7 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein NB-ARC PF00931.17 CCF37410.1 - 0.016 14.0 0.1 0.025 13.4 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain UPF0079 PF02367.12 CCF37410.1 - 0.02 14.5 0.0 0.037 13.6 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 APS_kinase PF01583.15 CCF37410.1 - 0.02 14.5 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase ATP_bind_1 PF03029.12 CCF37410.1 - 0.024 14.1 0.0 0.041 13.4 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_33 PF13671.1 CCF37410.1 - 0.028 14.3 0.0 0.048 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 CCF37410.1 - 0.028 14.3 0.0 0.052 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 CCF37410.1 - 0.042 13.5 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) YhjQ PF06564.7 CCF37410.1 - 0.048 13.0 0.4 0.12 11.7 0.0 1.7 2 0 0 2 2 2 0 YhjQ protein AAA_30 PF13604.1 CCF37410.1 - 0.069 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.13 CCF37410.1 - 0.069 12.2 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase ABC_tran PF00005.22 CCF37410.1 - 0.072 13.3 0.9 0.15 12.3 0.2 1.9 2 1 0 2 2 1 0 ABC transporter LpxK PF02606.9 CCF37410.1 - 0.08 11.8 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase KTI12 PF08433.5 CCF37410.1 - 0.1 11.7 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DUF87 PF01935.12 CCF37410.1 - 0.14 11.9 0.1 0.3 10.8 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function DUF87 adh_short PF00106.20 CCF37411.1 - 6.7e-63 211.5 6.2 1.3e-31 109.8 0.5 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.5 CCF37411.1 - 1.3e-32 112.8 0.9 7.8e-16 58.2 0.0 2.1 2 0 0 2 2 2 2 KR domain Epimerase PF01370.16 CCF37411.1 - 2.1e-05 24.1 4.1 0.0013 18.2 0.1 2.8 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.14 CCF37411.1 - 5.5e-05 22.2 1.7 0.0085 15.1 0.4 2.4 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Eno-Rase_NADH_b PF12242.3 CCF37411.1 - 0.34 10.7 4.7 0.69 9.7 0.1 2.5 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase PALP PF00291.20 CCF37411.1 - 1.8 7.7 9.5 0.41 9.8 0.6 2.9 2 1 0 3 3 3 0 Pyridoxal-phosphate dependent enzyme 3HCDH_N PF02737.13 CCF37411.1 - 8.9 5.9 7.6 22 4.6 0.5 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glyco_hydr_30_2 PF14587.1 CCF37412.1 - 2.2e-05 23.5 4.7 4.1e-05 22.6 3.2 1.4 1 1 0 1 1 1 1 O-Glycosyl hydrolase family 30 An_peroxidase PF03098.10 CCF37413.1 - 3.5e-105 352.4 0.0 8.3e-103 344.5 0.0 2.6 2 1 0 2 2 2 1 Animal haem peroxidase Peroxidase_2 PF01328.12 CCF37414.1 - 8.3e-21 73.9 0.0 5.8e-11 41.6 0.0 2.1 2 0 0 2 2 2 2 Peroxidase, family 2 Aft1_HRA PF11786.3 CCF37415.1 - 0.16 12.2 2.1 12 6.2 0.0 2.6 2 0 0 2 2 2 0 Aft1 HRA domain PAN_4 PF14295.1 CCF37416.1 - 0.14 11.8 2.0 1.4 8.7 1.4 2.3 1 1 0 1 1 1 0 PAN domain GATase_4 PF13230.1 CCF37417.1 - 3e-11 42.5 0.0 9.5e-09 34.3 0.0 2.8 2 1 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 CCF37417.1 - 2.5e-08 33.9 0.0 4.3e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain NiFe_hyd_SSU_C PF14720.1 CCF37418.1 - 0.92 9.5 8.5 1.3 9.0 3.0 2.0 1 1 1 2 2 2 0 NiFe/NiFeSe hydrogenase small subunit C-terminal Fip1 PF05182.8 CCF37420.1 - 6.6e-21 73.3 0.7 1.2e-20 72.4 0.5 1.4 1 0 0 1 1 1 1 Fip1 motif Herpes_UL32 PF06070.6 CCF37420.1 - 0.0072 14.8 5.0 0.0096 14.4 3.5 1.2 1 0 0 1 1 1 1 Herpesvirus large structural phosphoprotein UL32 zf-UDP PF14569.1 CCF37420.1 - 0.6 9.9 0.0 0.6 9.9 0.0 2.3 2 1 0 2 2 2 0 Zinc-binding RING-finger Nucleoporin_FG PF13634.1 CCF37421.1 - 1.2e-24 86.6 128.1 5.9e-16 58.7 36.5 3.4 1 1 2 3 3 3 3 Nucleoporin FG repeat region Tup_N PF08581.5 CCF37421.1 - 0.085 13.0 1.7 1.1 9.4 0.0 2.6 2 0 0 2 2 2 0 Tup N-terminal TFIIA PF03153.8 CCF37421.1 - 0.14 12.0 15.3 0.22 11.4 10.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 CCF37421.1 - 1.2 7.2 24.6 1.6 6.9 17.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RNA_pol_3_Rpc31 PF11705.3 CCF37422.1 - 0.00016 21.7 31.4 0.0002 21.4 21.8 1.0 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 DUF2076 PF09849.4 CCF37422.1 - 8.4 6.3 9.9 7.9 6.4 6.9 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) NTF2 PF02136.15 CCF37423.1 - 2e-23 82.9 0.2 3.4e-23 82.2 0.1 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.17 CCF37423.1 - 6e-06 25.8 0.1 1.1e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF37423.1 - 1.8e-05 24.6 0.0 3.7e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 CCF37423.1 - 0.002 17.9 0.0 0.0058 16.4 0.0 1.8 1 0 0 1 1 1 1 RNA binding motif RRM_5 PF13893.1 CCF37423.1 - 0.0029 17.4 0.0 0.0053 16.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sushi_2 PF09014.5 CCF37423.1 - 0.024 14.4 0.0 0.044 13.5 0.0 1.3 1 0 0 1 1 1 0 Beta-2-glycoprotein-1 fifth domain PAT1 PF09770.4 CCF37423.1 - 0.17 10.0 26.4 0.21 9.7 18.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EHN PF06441.7 CCF37424.1 - 9.3e-12 44.8 0.0 1.8e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Nnf1 PF03980.9 CCF37425.1 - 1.2e-27 96.0 1.8 1.2e-27 96.0 1.2 2.4 4 0 0 4 4 4 1 Nnf1 GrpE PF01025.14 CCF37425.1 - 0.065 12.7 3.7 0.48 9.9 0.1 2.5 1 1 1 2 2 2 0 GrpE GST_C_2 PF13410.1 CCF37425.1 - 0.13 12.2 0.9 0.4 10.5 0.7 1.9 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain SRP-alpha_N PF04086.8 CCF37425.1 - 9.6 5.4 10.3 5.8 6.2 0.0 2.1 1 1 1 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal PH_9 PF15410.1 CCF37426.1 - 3.4e-08 33.6 0.0 5.5e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 CCF37426.1 - 2.6e-06 27.5 0.0 4e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 PH domain Cellulase PF00150.13 CCF37428.1 - 1.7e-14 53.6 3.7 2.3e-14 53.2 2.6 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) PS_Dcarbxylase PF02666.10 CCF37430.1 - 4.2e-49 166.5 0.0 5.7e-49 166.1 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase RnfC_N PF13375.1 CCF37430.1 - 0.069 12.8 0.0 8 6.2 0.0 2.5 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain Cytochrom_B561 PF03188.11 CCF37431.1 - 0.026 14.3 8.8 0.052 13.3 6.1 1.5 1 0 0 1 1 1 0 Eukaryotic cytochrome b561 ABC2_membrane_2 PF12679.2 CCF37431.1 - 3.2 6.5 9.9 6.7 5.4 6.9 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein MFS_2 PF13347.1 CCF37432.1 - 2e-06 26.5 15.1 2e-06 26.5 10.5 2.9 2 1 1 3 3 3 1 MFS/sugar transport protein RasGAP PF00616.14 CCF37432.1 - 0.017 14.7 0.1 0.032 13.8 0.1 1.4 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase Na_H_Exchanger PF00999.16 CCF37433.1 - 8.1e-69 231.9 39.9 9.9e-69 231.6 27.7 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family CorA PF01544.13 CCF37434.1 - 1.5e-06 27.4 0.0 1.9e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF3995 PF13160.1 CCF37434.1 - 0.2 11.7 4.2 0.27 11.2 2.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3995) Rick_17kDa_Anti PF05433.10 CCF37438.1 - 0.00051 19.6 6.1 0.084 12.5 0.5 2.3 2 0 0 2 2 2 2 Glycine zipper 2TM domain Gly-zipper_OmpA PF13436.1 CCF37438.1 - 1.5 8.5 4.4 3.3 7.3 0.1 2.2 1 1 1 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain Gly-zipper_YMGG PF13441.1 CCF37438.1 - 6.5 6.3 9.3 36 3.9 6.4 2.0 1 1 0 1 1 1 0 YMGG-like Gly-zipper Amidohydro_1 PF01979.15 CCF37440.1 - 5.3e-62 210.4 2.0 1.2e-61 209.1 1.4 1.6 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.15 CCF37440.1 - 3.1e-54 182.2 2.3 6.7e-54 181.1 1.6 1.6 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.15 CCF37440.1 - 5.4e-40 135.2 1.0 1.5e-39 133.8 0.0 2.2 3 0 0 3 3 3 1 Urease beta subunit Urease_gamma PF00547.13 CCF37440.1 - 4.9e-36 122.7 0.0 1.1e-35 121.5 0.0 1.6 1 0 0 1 1 1 1 Urease, gamma subunit Amidohydro_5 PF13594.1 CCF37440.1 - 7.3e-07 28.9 3.7 2e-06 27.5 2.5 1.7 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 CCF37440.1 - 7.2e-06 25.4 1.5 0.00014 21.2 0.1 2.4 1 1 1 2 2 2 1 Amidohydrolase family Amidohydro_2 PF04909.9 CCF37440.1 - 0.00019 21.1 0.1 0.0031 17.1 0.0 2.2 2 0 0 2 2 2 1 Amidohydrolase DUF4604 PF15377.1 CCF37441.1 - 0.69 10.1 14.2 0.84 9.8 9.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Herpes_DNAp_acc PF04929.7 CCF37441.1 - 5.4 5.8 8.6 5.9 5.7 5.9 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Glyco_hydro_72 PF03198.9 CCF37442.1 - 4.5e-119 397.0 3.6 5.7e-119 396.7 2.5 1.0 1 0 0 1 1 1 1 Glucanosyltransferase G-alpha PF00503.15 CCF37445.1 - 6.8e-127 423.3 0.8 8e-127 423.1 0.6 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 CCF37445.1 - 6.4e-16 58.0 0.2 4.1e-10 39.1 0.1 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family Miro PF08477.8 CCF37445.1 - 0.001 19.5 0.0 0.84 10.1 0.0 2.8 3 0 0 3 3 3 2 Miro-like protein Gtr1_RagA PF04670.7 CCF37445.1 - 0.0025 16.9 4.2 0.17 11.0 0.1 2.6 1 1 1 2 2 2 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.1 CCF37445.1 - 0.049 13.1 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Penicil_amidase PF01804.13 CCF37445.1 - 0.1 11.5 0.1 3 6.7 0.0 2.0 2 0 0 2 2 2 0 Penicillin amidase DUF1776 PF08643.5 CCF37447.1 - 3.3e-108 361.3 0.0 4.1e-108 361.0 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Vps53_N PF04100.7 CCF37448.1 - 2.1e-97 326.3 0.2 3.7e-97 325.5 0.2 1.3 1 0 0 1 1 1 1 Vps53-like, N-terminal DUF2450 PF10475.4 CCF37448.1 - 0.016 14.1 5.7 0.036 12.9 4.0 1.6 1 0 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) Zw10 PF06248.8 CCF37448.1 - 1.5 6.8 6.2 0.58 8.2 1.8 2.0 2 0 0 2 2 2 0 Centromere/kinetochore Zw10 Spc7_N PF15402.1 CCF37449.1 - 9.9e-129 430.9 45.9 9.8e-114 381.3 18.4 3.9 2 1 3 5 5 5 4 N-terminus of kinetochore NMS complex subunit Spc7 Spc7 PF08317.6 CCF37449.1 - 1.1e-118 395.6 8.5 2.1e-118 394.7 5.9 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein Spc7_C2 PF15577.1 CCF37449.1 - 1e-18 66.6 0.4 2.4e-18 65.5 0.1 1.8 2 0 0 2 2 1 1 Spc7_C2 DUF812 PF05667.6 CCF37449.1 - 0.0029 16.1 5.2 0.006 15.1 3.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Reo_sigmaC PF04582.7 CCF37449.1 - 0.0073 15.5 0.8 0.013 14.6 0.5 1.3 1 0 0 1 1 1 1 Reovirus sigma C capsid protein MscS_porin PF12795.2 CCF37449.1 - 0.041 13.2 9.5 0.082 12.2 6.6 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain APG6 PF04111.7 CCF37449.1 - 0.11 11.5 10.1 0.29 10.1 7.0 1.6 1 0 0 1 1 1 0 Autophagy protein Apg6 Baculo_PEP_C PF04513.7 CCF37449.1 - 0.17 11.7 0.1 0.32 10.8 0.1 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus TBPIP PF07106.8 CCF37449.1 - 0.22 11.0 6.2 0.6 9.6 4.3 1.8 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF607 PF04678.8 CCF37449.1 - 0.36 10.7 1.7 1.1 9.2 1.2 1.8 1 0 0 1 1 1 0 Protein of unknown function, DUF607 COG2 PF06148.6 CCF37449.1 - 0.37 10.6 4.8 0.52 10.1 2.4 1.9 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Atg14 PF10186.4 CCF37449.1 - 0.53 9.1 8.6 0.44 9.4 4.8 1.7 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 V_ATPase_I PF01496.14 CCF37449.1 - 0.67 7.7 2.6 1.1 7.0 1.8 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Laminin_II PF06009.7 CCF37449.1 - 0.72 9.6 4.4 3.3 7.4 2.7 2.3 1 1 1 2 2 2 0 Laminin Domain II FUSC PF04632.7 CCF37449.1 - 0.84 7.9 2.0 1.8 6.8 1.4 1.5 1 0 0 1 1 1 0 Fusaric acid resistance protein family IncA PF04156.9 CCF37449.1 - 1.5 8.4 21.8 3 7.3 7.6 2.5 2 1 1 3 3 3 0 IncA protein TPR_MLP1_2 PF07926.7 CCF37449.1 - 1.7 8.4 14.3 27 4.4 8.9 2.9 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein Mnd1 PF03962.10 CCF37449.1 - 4.1 7.0 21.0 0.27 10.8 4.2 2.8 2 1 1 3 3 2 0 Mnd1 family Pox_A_type_inc PF04508.7 CCF37449.1 - 4.8 7.2 12.2 46 4.1 2.1 4.9 3 1 1 4 4 4 0 Viral A-type inclusion protein repeat Pkinase PF00069.20 CCF37450.1 - 3.7e-58 196.7 0.0 5.7e-58 196.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF37450.1 - 9.7e-43 146.0 0.0 1.5e-42 145.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF37450.1 - 3.7e-05 22.8 0.0 0.00019 20.4 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 CCF37450.1 - 0.011 15.4 0.0 0.028 14.1 0.0 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 CCF37450.1 - 0.016 14.3 0.0 0.032 13.2 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Complex1_49kDa PF00346.14 CCF37452.1 - 7.8e-135 448.1 0.0 1e-134 447.7 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit FAD_binding_3 PF01494.14 CCF37453.1 - 3.4e-25 88.8 0.0 5.6e-23 81.5 0.0 2.2 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF37453.1 - 7.8e-06 25.0 0.1 0.0015 17.5 0.1 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 CCF37453.1 - 1.7e-05 23.9 0.1 0.00012 21.0 0.0 2.3 2 1 0 2 2 2 1 Lycopene cyclase protein SE PF08491.5 CCF37453.1 - 0.00027 19.8 0.0 0.00042 19.2 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase NAD_binding_9 PF13454.1 CCF37453.1 - 0.0045 16.7 0.0 0.0089 15.8 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 CCF37453.1 - 0.0056 16.5 0.0 0.012 15.4 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF37453.1 - 0.019 14.0 0.0 0.45 9.5 0.0 2.3 2 0 0 2 2 2 0 Thi4 family K_oxygenase PF13434.1 CCF37453.1 - 0.02 13.8 0.0 0.066 12.1 0.0 1.9 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.9 CCF37453.1 - 0.07 11.7 0.0 1.8 7.1 0.0 2.5 3 0 0 3 3 3 0 Tryptophan halogenase NAD_binding_8 PF13450.1 CCF37453.1 - 0.084 12.9 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 CCF37453.1 - 0.11 10.9 0.0 0.15 10.4 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein MSC PF09402.5 CCF37454.1 - 3e-98 328.6 0.0 4.2e-98 328.1 0.0 1.1 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.2 CCF37454.1 - 1.1e-16 60.0 0.1 2.4e-16 58.9 0.1 1.6 1 0 0 1 1 1 1 HeH/LEM domain DUF2630 PF10944.3 CCF37454.1 - 0.012 15.7 1.7 0.2 11.8 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2630) DUF3350 PF11830.3 CCF37454.1 - 0.051 13.6 0.5 13 5.8 0.0 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3350) Trypan_PARP PF05887.6 CCF37454.1 - 0.43 10.3 11.9 0.71 9.6 5.1 2.7 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Mt_ATP-synt_B PF05405.9 CCF37455.1 - 1.3e-52 177.5 2.7 1.6e-52 177.2 1.9 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) tRNA_anti-codon PF01336.20 CCF37455.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain DUF3176 PF11374.3 CCF37457.1 - 3.6e-39 133.0 1.8 1e-38 131.6 1.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) DUF2254 PF10011.4 CCF37457.1 - 0.76 8.1 5.6 1.2 7.4 3.4 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2254) ADH_N PF08240.7 CCF37459.1 - 9.6e-12 44.6 0.0 1.2e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain GAF_2 PF13185.1 CCF37459.1 - 0.0029 18.1 0.0 0.0032 17.9 0.0 1.1 1 0 0 1 1 1 1 GAF domain COesterase PF00135.23 CCF37461.1 - 7.5e-78 262.5 0.0 9e-78 262.2 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF37461.1 - 4.1e-07 29.7 0.1 1.7e-06 27.7 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF37461.1 - 0.016 14.4 0.0 0.027 13.7 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Ribonuc_L-PSP PF01042.16 CCF37462.1 - 5.2e-39 132.7 0.0 6.3e-39 132.4 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Clat_adaptor_s PF01217.15 CCF37463.1 - 1.6e-35 121.8 1.4 1.9e-35 121.6 1.0 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain LRRNT PF01462.13 CCF37464.1 - 0.15 11.5 1.9 0.38 10.2 0.4 2.1 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain Maf1 PF09174.5 CCF37465.1 - 9.1e-52 175.5 0.0 1.2e-51 175.0 0.0 1.2 1 0 0 1 1 1 1 Maf1 regulator CH PF00307.26 CCF37467.1 - 1.2e-38 131.4 0.2 9.6e-19 67.4 0.0 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.5 CCF37467.1 - 3.8e-26 90.8 0.0 1.4e-25 89.0 0.0 2.0 1 0 0 1 1 1 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.3 CCF37467.1 - 2.9e-11 42.8 0.4 3.9e-07 29.6 0.0 2.9 3 0 0 3 3 3 2 CAMSAP CH domain EF-hand_6 PF13405.1 CCF37467.1 - 0.00071 19.2 0.5 0.0076 16.0 0.1 2.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.1 CCF37467.1 - 0.012 15.2 1.2 0.098 12.2 0.1 2.8 1 1 2 3 3 3 0 EF-hand domain pair DUF1088 PF06469.6 CCF37467.1 - 0.012 15.0 0.9 0.91 8.9 0.0 2.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1088) EF-hand_1 PF00036.27 CCF37467.1 - 0.059 12.7 0.2 0.49 9.8 0.0 2.5 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.1 CCF37467.1 - 0.27 11.3 2.5 1.5 8.9 1.7 2.3 1 0 0 1 1 1 0 EF-hand domain pair Cytochrom_B562 PF07361.6 CCF37467.1 - 0.45 10.9 3.4 8.4 6.8 0.1 3.6 4 0 0 4 4 4 0 Cytochrome b562 PUF PF00806.14 CCF37468.1 - 8.7e-65 210.7 15.3 8e-09 34.5 0.1 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat SapB_2 PF03489.12 CCF37468.1 - 0.069 13.1 0.4 8.3 6.5 0.0 3.2 2 0 0 2 2 2 0 Saposin-like type B, region 2 MgtE_N PF03448.12 CCF37468.1 - 0.17 12.1 1.0 34 4.8 0.0 3.5 4 0 0 4 4 4 0 MgtE intracellular N domain DPBB_1 PF03330.13 CCF37469.1 - 0.00035 20.5 0.0 0.00062 19.7 0.0 1.5 1 0 0 1 1 1 1 Rare lipoprotein A (RlpA)-like double-psi beta-barrel Barwin PF00967.12 CCF37469.1 - 0.0054 16.3 0.6 0.0096 15.5 0.4 1.4 1 1 0 1 1 1 1 Barwin family CorA PF01544.13 CCF37470.1 - 0.00038 19.5 0.0 0.00038 19.5 0.0 1.7 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein DUF3543 PF12063.3 CCF37471.1 - 2.9e-87 291.8 0.8 4.3e-87 291.2 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.20 CCF37471.1 - 5.4e-60 202.7 0.0 1.4e-59 201.3 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF37471.1 - 1.9e-42 145.1 0.0 3.6e-42 144.2 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase MIT PF04212.13 CCF37471.1 - 0.00083 19.1 0.1 0.33 10.8 0.0 2.6 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain Pox_ser-thr_kin PF05445.6 CCF37471.1 - 0.26 10.0 0.0 0.39 9.4 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase WD40 PF00400.27 CCF37472.1 - 8.8e-40 133.1 7.5 3.3e-10 39.4 0.2 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.3 CCF37472.1 - 2.8e-05 22.4 8.4 0.018 13.1 0.3 4.2 2 2 3 5 5 5 2 Nucleoporin Nup120/160 IncA PF04156.9 CCF37472.1 - 0.042 13.4 1.4 0.071 12.7 1.0 1.4 1 0 0 1 1 1 0 IncA protein APG6 PF04111.7 CCF37472.1 - 0.068 12.2 0.4 0.11 11.5 0.3 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 PQQ_2 PF13360.1 CCF37472.1 - 0.11 11.8 1.1 0.97 8.8 0.0 2.4 2 1 0 3 3 3 0 PQQ-like domain Cupin_8 PF13621.1 CCF37473.1 - 1.3e-31 109.9 0.0 2.1e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 CCF37473.1 - 3.8e-09 36.2 0.0 2.7e-06 26.8 0.0 2.2 2 0 0 2 2 2 2 Cupin superfamily protein JmjC PF02373.17 CCF37473.1 - 0.0005 20.2 0.0 0.0033 17.6 0.0 2.1 2 0 0 2 2 2 1 JmjC domain, hydroxylase Cupin_2 PF07883.6 CCF37473.1 - 0.021 14.2 0.0 0.045 13.2 0.0 1.4 1 0 0 1 1 1 0 Cupin domain Mif2_N PF15624.1 CCF37474.1 - 4.2e-35 121.3 3.4 4.2e-35 121.3 2.3 3.8 3 1 0 3 3 3 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal CENP-C_C PF11699.3 CCF37474.1 - 1e-34 118.3 0.2 1.9e-34 117.4 0.1 1.5 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_2 PF07883.6 CCF37474.1 - 5.8e-08 32.1 0.0 1.3e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.2 CCF37474.1 - 0.0022 17.6 0.5 0.0048 16.5 0.0 1.8 2 0 0 2 2 2 1 Cupin Cupin_3 PF05899.7 CCF37474.1 - 0.0041 16.4 0.0 0.011 15.0 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_1 PF00190.17 CCF37474.1 - 0.038 13.4 0.0 0.077 12.4 0.0 1.4 1 0 0 1 1 1 0 Cupin RNase_HII PF01351.13 CCF37475.1 - 1.2e-46 158.8 0.0 1.5e-46 158.5 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII BHD_2 PF10404.4 CCF37476.1 - 0.1 12.9 2.0 0.21 11.9 1.4 1.5 1 0 0 1 1 1 0 Rad4 beta-hairpin domain 2 Coiled-coil_56 PF09813.4 CCF37476.1 - 0.18 11.8 1.0 0.77 9.7 0.0 2.1 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 56 NAD_binding_8 PF13450.1 CCF37477.1 - 1.2e-11 44.4 0.4 3.6e-11 42.9 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF37477.1 - 2.4e-05 23.4 0.1 0.00048 19.1 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 CCF37477.1 - 3.7e-05 23.8 0.0 0.0011 19.1 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 CCF37477.1 - 4.2e-05 22.8 0.0 6.5e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.19 CCF37477.1 - 9.1e-05 21.4 0.4 0.00013 20.9 0.3 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 CCF37477.1 - 0.00027 20.8 0.0 0.00052 19.9 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF37477.1 - 0.001 17.6 0.3 0.0018 16.7 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.2 CCF37477.1 - 0.0013 17.8 0.0 0.002 17.2 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 CCF37477.1 - 0.0014 17.7 0.1 0.0025 16.9 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Trp_halogenase PF04820.9 CCF37477.1 - 0.014 14.0 0.3 0.089 11.3 0.2 1.9 2 0 0 2 2 2 0 Tryptophan halogenase GMC_oxred_N PF00732.14 CCF37477.1 - 0.05 12.7 0.0 0.084 12.0 0.0 1.3 1 0 0 1 1 1 0 GMC oxidoreductase GIDA PF01134.17 CCF37477.1 - 0.067 12.0 0.4 0.1 11.4 0.3 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.22 CCF37477.1 - 0.095 13.1 0.1 0.35 11.2 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.13 CCF37477.1 - 0.17 11.8 0.5 0.45 10.5 0.1 1.8 2 0 0 2 2 2 0 TrkA-N domain Cupin_1 PF00190.17 CCF37479.1 - 7.4e-10 38.4 0.0 1.3e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.6 CCF37479.1 - 0.001 18.5 0.0 0.0033 16.8 0.0 1.8 1 1 0 1 1 1 1 Cupin domain Glyco_hydro_47 PF01532.15 CCF37480.1 - 5.4e-163 542.8 0.1 6.2e-163 542.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF4038 PF13204.1 CCF37480.1 - 0.0018 17.6 0.0 0.004 16.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4038) SKG6 PF08693.5 CCF37481.1 - 3.2e-06 26.3 1.6 3.2e-06 26.3 1.1 2.0 2 0 0 2 2 2 1 Transmembrane alpha-helix domain ATP_synt_I PF03899.10 CCF37481.1 - 0.021 14.9 0.2 0.083 13.0 0.0 1.9 2 0 0 2 2 2 0 ATP synthase I chain SMP PF04927.7 CCF37482.1 - 0.0001 22.2 3.8 0.00014 21.7 2.6 1.3 1 0 0 1 1 1 1 Seed maturation protein Trypan_PARP PF05887.6 CCF37482.1 - 0.67 9.7 4.0 0.68 9.7 2.8 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF904 PF06005.7 CCF37483.1 - 0.00019 21.6 11.9 0.16 12.2 0.9 3.2 2 1 1 3 3 3 2 Protein of unknown function (DUF904) APG6 PF04111.7 CCF37483.1 - 0.0012 18.0 7.5 0.0012 17.9 4.6 1.4 1 1 0 1 1 1 1 Autophagy protein Apg6 GAS PF13851.1 CCF37483.1 - 0.004 16.3 11.3 0.011 14.9 4.0 2.4 1 1 2 3 3 3 2 Growth-arrest specific micro-tubule binding ERM PF00769.14 CCF37483.1 - 0.019 14.4 9.0 0.048 13.1 6.2 1.6 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF4407 PF14362.1 CCF37483.1 - 0.042 12.8 2.4 0.06 12.2 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spectrin PF00435.16 CCF37483.1 - 0.063 13.5 3.1 0.069 13.4 1.0 1.9 1 1 0 1 1 1 0 Spectrin repeat LPP PF04728.8 CCF37483.1 - 0.072 12.8 0.2 0.22 11.3 0.1 1.9 2 0 0 2 2 2 0 Lipoprotein leucine-zipper TMF_DNA_bd PF12329.3 CCF37483.1 - 0.094 12.5 6.4 1.9 8.3 1.4 2.6 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding CCDC155 PF14662.1 CCF37483.1 - 0.15 11.6 13.6 1.7 8.2 9.5 2.3 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 HALZ PF02183.13 CCF37483.1 - 0.16 11.7 16.4 4.8 6.9 0.1 4.4 4 0 0 4 4 4 0 Homeobox associated leucine zipper Laminin_II PF06009.7 CCF37483.1 - 0.19 11.5 2.6 0.3 10.8 1.8 1.3 1 0 0 1 1 1 0 Laminin Domain II ADIP PF11559.3 CCF37483.1 - 0.2 11.5 13.8 0.057 13.3 4.6 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF972 PF06156.8 CCF37483.1 - 0.3 11.4 11.2 1.4 9.2 2.3 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF972) Spc7 PF08317.6 CCF37483.1 - 0.38 9.3 7.9 0.6 8.7 5.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4515 PF14988.1 CCF37483.1 - 0.81 9.3 13.2 0.62 9.6 0.9 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4515) TPR_MLP1_2 PF07926.7 CCF37483.1 - 0.9 9.2 9.8 12 5.6 6.3 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Kinetocho_Slk19 PF12709.2 CCF37483.1 - 1.5 8.9 7.1 4.3 7.4 0.4 3.3 2 1 2 4 4 4 0 Central kinetochore-associated TSC22 PF01166.13 CCF37483.1 - 7.8 6.5 10.8 11 6.0 0.5 3.1 3 0 0 3 3 3 0 TSC-22/dip/bun family Rabaptin PF03528.10 CCF37483.1 - 8 6.4 7.8 1.5 8.7 2.5 1.9 2 0 0 2 2 2 0 Rabaptin DUF4200 PF13863.1 CCF37483.1 - 9.8 6.1 14.4 4 7.3 0.4 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) Elongin_A PF06881.6 CCF37484.1 - 6.3e-20 71.5 1.5 1e-19 70.9 1.1 1.2 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A TFIIF_beta PF02270.10 CCF37485.1 - 5e-61 206.9 2.8 6.1e-61 206.6 2.0 1.0 1 0 0 1 1 1 1 Transcription initiation factor IIF, beta subunit DUF2336 PF10098.4 CCF37485.1 - 1.2 8.3 6.8 0.13 11.4 1.2 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2336) HAD PF12710.2 CCF37486.1 - 5.4e-21 75.6 0.1 1.2e-20 74.4 0.1 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 CCF37486.1 - 0.00018 21.7 0.0 0.001 19.3 0.0 2.1 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CCF37486.1 - 0.0006 20.2 0.0 0.001 19.5 0.0 1.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.7 CCF37486.1 - 0.013 14.7 0.1 0.86 8.7 0.0 2.8 2 1 0 2 2 2 0 Putative Phosphatase LNS2 PF08235.8 CCF37486.1 - 0.022 14.3 0.1 5.5 6.5 0.0 2.4 2 0 0 2 2 2 0 LNS2 (Lipin/Ned1/Smp2) Rsa3 PF14615.1 CCF37487.1 - 1.7e-21 75.2 0.5 2.3e-21 74.7 0.4 1.2 1 0 0 1 1 1 1 Ribosome-assembly protein 3 Ytp1 PF10355.4 CCF37488.1 - 7.3e-113 376.2 3.2 1.1e-112 375.6 2.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.4 CCF37488.1 - 2.1e-32 110.8 6.9 2.1e-32 110.8 4.8 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) Ca_hom_mod PF14798.1 CCF37488.1 - 0.047 12.6 0.1 0.3 10.0 0.1 2.0 2 0 0 2 2 2 0 Calcium homeostasis modulator GFA PF04828.9 CCF37489.1 - 9.2e-21 73.6 0.9 9.2e-21 73.6 0.6 1.3 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Zn_ribbon_recom PF13408.1 CCF37489.1 - 0.93 9.7 4.8 1 9.7 0.1 2.7 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain Ferric_reduct PF01794.14 CCF37490.1 - 8.4e-18 64.6 3.7 8.4e-18 64.6 2.6 2.4 3 1 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 CCF37490.1 - 5.4e-15 55.1 0.1 3.6e-14 52.5 0.0 2.1 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_6 PF08030.7 CCF37490.1 - 7.4e-14 51.9 0.0 1.5e-12 47.7 0.0 2.3 1 1 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.16 CCF37490.1 - 6.7e-05 23.4 0.0 0.04 14.4 0.0 2.9 3 0 0 3 3 3 2 Oxidoreductase NAD-binding domain KilA-N PF04383.8 CCF37492.1 - 0.00062 19.3 0.0 0.0075 15.8 0.0 2.3 1 1 0 1 1 1 1 KilA-N domain p450 PF00067.17 CCF37496.1 - 8.6e-29 100.3 0.0 9.4e-29 100.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.11 CCF37497.1 - 2.7e-36 125.0 47.6 2.7e-36 125.0 33.0 3.1 2 1 0 2 2 2 1 Major Facilitator Superfamily BofA PF07441.6 CCF37497.1 - 0.0021 18.0 0.7 0.011 15.7 0.1 2.6 1 1 1 2 2 2 1 SigmaK-factor processing regulatory protein BofA RasGAP_C PF03836.10 CCF37498.1 - 2.2e-49 166.7 2.0 2.2e-49 166.7 1.4 2.1 2 1 0 2 2 2 1 RasGAP C-terminus RasGAP PF00616.14 CCF37498.1 - 1.4e-41 142.2 0.0 4.9e-41 140.5 0.0 2.0 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase IQ PF00612.22 CCF37498.1 - 1.6e-05 24.0 10.5 0.17 11.6 0.3 5.8 5 0 0 5 5 5 4 IQ calmodulin-binding motif CcoS PF03597.10 CCF37499.1 - 0.024 14.1 0.4 0.03 13.8 0.2 1.1 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type HET PF06985.6 CCF37501.1 - 7.2e-18 65.0 0.0 1.9e-17 63.7 0.0 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) MbtH PF03621.8 CCF37501.1 - 0.027 13.8 0.0 0.078 12.3 0.0 1.7 1 0 0 1 1 1 0 MbtH-like protein Tannase PF07519.6 CCF37502.1 - 2.9e-06 26.2 2.3 5.7e-06 25.3 1.6 1.5 1 1 0 1 1 1 1 Tannase and feruloyl esterase Rox3 PF08633.5 CCF37504.1 - 3.1e-41 141.8 0.9 3.2e-40 138.5 0.0 2.2 2 1 0 2 2 2 1 Rox3 mediator complex subunit MCM PF00493.18 CCF37506.1 - 6.2e-142 472.2 0.1 8.5e-142 471.8 0.1 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 CCF37506.1 - 5.9e-20 71.9 1.7 8.3e-20 71.4 0.5 1.8 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 CCF37506.1 - 1.5e-06 27.5 0.0 0.0002 20.5 0.0 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 CCF37506.1 - 2.2e-05 24.1 0.0 4.6e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 CCF37506.1 - 0.00056 19.5 0.0 0.0024 17.4 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 CCF37506.1 - 0.045 13.2 0.0 1.5 8.3 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase_2 PF13335.1 CCF37506.1 - 0.054 13.8 1.8 0.11 12.9 0.2 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Vps54 PF07928.7 CCF37507.1 - 6.3e-48 162.3 0.1 3.6e-47 159.8 0.0 2.4 3 0 0 3 3 3 1 Vps54-like protein DUF2450 PF10475.4 CCF37507.1 - 2e-06 26.9 0.6 5.8e-06 25.4 0.4 1.7 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) Sec8_exocyst PF04048.9 CCF37507.1 - 0.019 14.5 0.3 0.19 11.3 0.1 2.6 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain DUF2451 PF10474.4 CCF37507.1 - 0.037 13.7 0.0 0.079 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2451) Spc7 PF08317.6 CCF37507.1 - 0.06 12.0 0.7 0.14 10.8 0.5 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF904 PF06005.7 CCF37507.1 - 0.9 9.8 7.2 0.16 12.3 0.9 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF904) COG2 PF06148.6 CCF37507.1 - 1 9.2 7.4 0.15 11.9 0.9 2.7 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 COG5 PF10392.4 CCF37507.1 - 1.3 9.0 5.1 9.4 6.2 0.9 3.0 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Mucin PF01456.12 CCF37513.1 - 0.26 11.0 7.2 11 5.7 0.0 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein Cytochrome-c551 PF10643.4 CCF37515.1 - 0.05 12.8 0.7 0.061 12.6 0.5 1.1 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 UPF0126 PF03458.8 CCF37515.1 - 0.071 12.7 1.9 0.084 12.5 1.3 1.2 1 0 0 1 1 1 0 UPF0126 domain 4HBT_2 PF13279.1 CCF37517.1 - 1.3e-08 35.3 0.0 1.9e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Thioesterase-like superfamily adh_short PF00106.20 CCF37518.1 - 7.7e-16 58.4 0.4 8.9e-16 58.2 0.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF37518.1 - 4e-08 33.1 0.1 4.4e-08 32.9 0.0 1.0 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.13 CCF37518.1 - 0.00034 20.3 0.0 0.00039 20.1 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.10 CCF37518.1 - 0.00036 19.5 0.0 0.00041 19.3 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Ldh_1_N PF00056.18 CCF37518.1 - 0.00054 19.8 0.1 0.00057 19.7 0.1 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Epimerase PF01370.16 CCF37518.1 - 0.0087 15.5 0.0 0.0097 15.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 CCF37518.1 - 0.013 15.3 0.0 0.015 15.0 0.0 1.1 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase THF_DHG_CYH_C PF02882.14 CCF37518.1 - 0.051 12.6 0.0 0.073 12.1 0.0 1.2 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ELFV_dehydrog PF00208.16 CCF37518.1 - 0.059 12.9 0.1 0.075 12.5 0.1 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ThiF PF00899.16 CCF37518.1 - 0.082 12.7 0.9 0.12 12.2 0.6 1.2 1 0 0 1 1 1 0 ThiF family 2-Hacid_dh_C PF02826.14 CCF37518.1 - 0.1 11.7 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DapB_N PF01113.15 CCF37518.1 - 0.1 12.5 0.3 0.15 11.9 0.2 1.4 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus p450 PF00067.17 CCF37519.1 - 1.6e-23 83.0 0.0 3.6e-23 81.8 0.0 1.5 2 0 0 2 2 2 1 Cytochrome P450 p450 PF00067.17 CCF37520.1 - 8e-16 57.6 0.0 1.4e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 Cytochrome P450 Asp PF00026.18 CCF37521.1 - 7.9e-25 87.7 0.0 9.5e-25 87.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.1 CCF37521.1 - 0.0051 17.2 0.3 0.023 15.1 0.1 2.2 2 1 0 2 2 2 1 Aspartyl protease TAXi_C PF14541.1 CCF37521.1 - 0.013 15.0 0.0 0.11 12.0 0.0 2.3 3 0 0 3 3 3 0 Xylanase inhibitor C-terminal Acyl_transf_1 PF00698.16 CCF37523.1 - 2.3e-72 244.0 0.3 3.3e-72 243.5 0.2 1.2 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.1 CCF37523.1 - 1.8e-54 184.9 0.9 3e-54 184.2 0.7 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase ADH_N PF08240.7 CCF37523.1 - 3.5e-07 29.9 0.0 9e-07 28.6 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_31 PF13847.1 CCF37523.1 - 0.0042 16.6 0.0 0.0087 15.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF37523.1 - 0.01 16.2 0.0 0.045 14.2 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.7 CCF37523.1 - 0.11 13.0 0.0 0.25 11.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain RNA_pol_Rpb1_1 PF04997.7 CCF37524.1 - 3.6e-111 371.6 0.0 4.3e-111 371.4 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.15 CCF37524.1 - 1.9e-70 236.1 0.0 3.3e-70 235.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 CCF37524.1 - 1.2e-11 44.5 0.0 2.1e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 WD40 PF00400.27 CCF37525.1 - 3.2e-14 52.1 8.1 0.00043 20.0 0.4 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat eIF2A PF08662.6 CCF37525.1 - 9.3e-06 25.4 0.3 0.012 15.3 0.0 3.3 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Clathrin_propel PF01394.15 CCF37525.1 - 0.034 14.4 0.4 16 6.0 0.0 3.4 4 0 0 4 4 4 0 Clathrin propeller repeat Thg1 PF04446.7 CCF37526.1 - 7.9e-20 70.8 0.0 8.5e-20 70.7 0.0 1.0 1 0 0 1 1 1 1 tRNAHis guanylyltransferase PepSY_TM_3 PF13706.1 CCF37527.1 - 0.091 12.1 0.1 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 PepSY-associated TM helix DndB PF14072.1 CCF37527.1 - 0.12 11.5 0.1 0.18 10.9 0.1 1.2 1 0 0 1 1 1 0 DNA-sulfur modification-associated PABP PF00658.13 CCF37528.1 - 1.2e-28 98.5 0.7 1.9e-28 97.9 0.5 1.3 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain SCPU PF05229.10 CCF37529.1 - 0.14 12.2 0.0 0.2 11.7 0.0 1.2 1 0 0 1 1 1 0 Spore Coat Protein U domain AhpC-TSA_2 PF13911.1 CCF37530.1 - 8.9e-19 67.5 0.0 4.3e-18 65.3 0.0 2.0 2 0 0 2 2 2 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.16 CCF37530.1 - 0.0054 16.4 0.0 0.014 15.0 0.0 1.7 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 CCF37530.1 - 0.02 14.4 0.0 0.041 13.4 0.0 1.5 1 0 0 1 1 1 0 Redoxin SNARE_assoc PF09335.6 CCF37531.1 - 2.1e-18 66.6 9.7 3.7e-18 65.8 5.4 2.2 2 0 0 2 2 2 1 SNARE associated Golgi protein DUF3483 PF11982.3 CCF37531.1 - 0.63 9.2 3.8 3.1 7.0 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3483) DUF1469 PF07332.6 CCF37531.1 - 1.2 8.8 10.1 0.048 13.3 0.6 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1469) Acyl_transf_1 PF00698.16 CCF37533.1 - 2.4e-61 207.8 0.0 3.3e-61 207.3 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain MaoC_dehydratas PF01575.14 CCF37533.1 - 4.1e-29 100.4 0.1 1.3e-28 98.8 0.0 1.8 2 0 0 2 2 2 1 MaoC like domain DUF1729 PF08354.5 CCF37533.1 - 2.2e-28 97.7 0.1 6e-28 96.4 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) MaoC_dehydrat_N PF13452.1 CCF37533.1 - 2e-08 34.0 0.0 5.5e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase Lipoprotein_20 PF13942.1 CCF37533.1 - 0.12 11.9 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 YfhG lipoprotein DUF566 PF04484.7 CCF37534.1 - 0.14 11.6 10.9 0.19 11.1 7.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) Lin-8 PF03353.10 CCF37534.1 - 0.71 9.1 11.3 1.3 8.2 7.8 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MFS_1 PF07690.11 CCF37537.1 - 2.7e-36 125.0 37.9 2.7e-36 125.0 26.3 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF37537.1 - 1.8e-07 30.0 35.0 2.4e-06 26.4 4.3 3.0 3 0 0 3 3 3 2 Sugar (and other) transporter Methyltransf_23 PF13489.1 CCF37538.1 - 2.5e-09 37.0 0.0 3.4e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF37538.1 - 6e-05 23.5 0.1 0.00053 20.5 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF37538.1 - 0.00014 21.4 0.0 0.018 14.6 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_4 PF02390.12 CCF37538.1 - 0.1 11.6 0.0 0.21 10.6 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_16 PF10294.4 CCF37538.1 - 0.13 11.7 0.0 0.38 10.1 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase MTS PF05175.9 CCF37538.1 - 0.14 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_25 PF13649.1 CCF37538.1 - 0.16 12.3 0.0 0.34 11.2 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain PH_10 PF15411.1 CCF37539.1 - 3e-46 156.3 0.3 6.3e-46 155.3 0.2 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain CDC24 PF06395.6 CCF37539.1 - 1e-32 112.0 0.0 2.1e-32 111.0 0.0 1.6 1 0 0 1 1 1 1 CDC24 Calponin RhoGEF PF00621.15 CCF37539.1 - 1.4e-32 113.0 0.1 2.4e-32 112.2 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain PB1 PF00564.19 CCF37539.1 - 3.7e-08 32.9 0.0 8.9e-08 31.6 0.0 1.7 1 0 0 1 1 1 1 PB1 domain PH PF00169.24 CCF37539.1 - 0.028 14.6 0.1 0.055 13.6 0.1 1.5 1 0 0 1 1 1 0 PH domain Glyco_transf_8 PF01501.15 CCF37540.1 - 0.00074 18.9 1.1 0.0055 16.0 0.8 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.3 CCF37540.1 - 0.00077 18.8 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Kelch_4 PF13418.1 CCF37541.1 - 2.7e-20 71.8 0.7 2.5e-08 33.5 0.0 5.3 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.1 CCF37541.1 - 3.7e-19 68.2 2.5 0.00099 19.0 0.0 5.7 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.1 CCF37541.1 - 2.4e-15 56.1 3.1 4.1e-06 26.8 0.0 6.1 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.1 CCF37541.1 - 4e-11 42.5 1.4 0.0014 18.7 0.0 5.2 5 1 1 6 6 6 3 Kelch motif Kelch_2 PF07646.10 CCF37541.1 - 4.8e-08 32.4 2.2 0.0044 16.7 0.0 4.6 5 1 1 6 6 6 2 Kelch motif Kelch_1 PF01344.20 CCF37541.1 - 2e-07 30.4 0.0 0.82 9.2 0.0 4.5 4 0 0 4 4 4 3 Kelch motif S10_plectin PF03501.10 CCF37542.1 - 0.14 12.0 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Plectin/S10 domain UCR_TM PF02921.9 CCF37543.1 - 8.3e-19 67.5 0.8 8.3e-19 67.5 0.6 2.2 2 0 0 2 2 2 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.21 CCF37543.1 - 5.1e-17 61.2 0.0 8.3e-17 60.5 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain CPSF_A PF03178.10 CCF37544.1 - 2.6e-48 164.7 0.0 3e-48 164.5 0.0 1.0 1 0 0 1 1 1 1 CPSF A subunit region Fungal_trans PF04082.13 CCF37545.1 - 1.3e-20 73.3 0.4 2.5e-20 72.4 0.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF37545.1 - 7.1e-06 25.8 7.0 1.5e-05 24.7 4.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UPF0560 PF10577.4 CCF37545.1 - 0.36 9.0 4.9 0.52 8.5 3.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 SNARE PF05739.14 CCF37547.1 - 2e-11 43.3 8.6 2e-11 43.3 5.9 3.1 3 1 0 3 3 3 1 SNARE domain Syntaxin PF00804.20 CCF37547.1 - 9.9e-07 28.8 1.4 9.9e-07 28.8 1.0 2.6 2 1 0 2 2 2 1 Syntaxin Syntaxin_2 PF14523.1 CCF37547.1 - 0.0023 17.9 1.2 0.0023 17.9 0.8 2.5 1 1 1 2 2 2 1 Syntaxin-like protein DUF515 PF04415.7 CCF37547.1 - 0.0045 15.2 0.6 0.0094 14.2 0.2 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF515) OppC_N PF12911.2 CCF37547.1 - 0.0045 16.3 0.1 0.0097 15.2 0.1 1.5 1 0 0 1 1 1 1 N-terminal TM domain of oligopeptide transport permease C YajC PF02699.10 CCF37547.1 - 0.017 14.7 0.2 0.054 13.1 0.2 1.8 1 0 0 1 1 1 0 Preprotein translocase subunit DUF912 PF06024.7 CCF37547.1 - 0.019 15.0 0.4 0.048 13.7 0.2 1.7 1 1 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF805 PF05656.9 CCF37547.1 - 0.08 12.7 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF805) HrpA_pilin PF09589.5 CCF37547.1 - 0.082 13.3 4.1 0.33 11.3 2.8 2.1 1 1 0 1 1 1 0 HrpA pilus formation protein OPT PF03169.10 CCF37547.1 - 0.089 11.1 0.0 0.12 10.7 0.0 1.2 1 0 0 1 1 1 0 OPT oligopeptide transporter protein MitMem_reg PF13012.1 CCF37547.1 - 0.1 12.6 0.3 0.1 12.6 0.2 2.3 2 0 0 2 2 2 0 Maintenance of mitochondrial structure and function V-SNARE PF05008.10 CCF37547.1 - 0.16 12.1 10.7 0.63 10.2 2.5 3.3 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus DUF3328 PF11807.3 CCF37547.1 - 0.18 11.4 0.1 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) Allexi_40kDa PF05549.6 CCF37547.1 - 0.3 10.3 6.1 0.37 10.0 0.2 2.2 2 0 0 2 2 2 0 Allexivirus 40kDa protein Lge1 PF11488.3 CCF37547.1 - 0.62 10.3 3.0 3.9 7.7 0.0 2.6 2 1 0 2 2 2 0 Transcriptional regulatory protein LGE1 Rifin_STEVOR PF02009.11 CCF37547.1 - 1.9 8.0 9.1 6.9 6.2 6.0 2.0 1 1 1 2 2 2 0 Rifin/stevor family DUF2229 PF09989.4 CCF37547.1 - 1.9 7.8 4.6 2.1 7.7 0.8 2.2 1 1 1 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) DUF2763 PF10961.3 CCF37547.1 - 6.6 7.1 6.7 12 6.3 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2763) EI24 PF07264.6 CCF37548.1 - 5.1e-07 29.3 10.1 1.8e-05 24.2 7.0 2.3 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Lumazine_bd_2 PF12893.2 CCF37548.1 - 0.15 12.6 0.2 0.59 10.6 0.0 2.0 2 0 0 2 2 2 0 Putative lumazine-binding FmdA_AmdA PF03069.10 CCF37549.1 - 1.2e-66 224.9 0.0 1.4e-66 224.7 0.0 1.0 1 0 0 1 1 1 1 Acetamidase/Formamidase family C2 PF00168.25 CCF37550.1 - 6e-16 58.0 0.0 4.5e-13 48.8 0.0 2.4 2 0 0 2 2 2 2 C2 domain DUF2404 PF10296.4 CCF37550.1 - 0.0063 16.6 0.0 0.015 15.3 0.0 1.6 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) HET PF06985.6 CCF37551.1 - 2.1e-35 121.9 0.0 4.4e-35 120.8 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Glyco_hydro_1 PF00232.13 CCF37552.1 - 4.4e-144 480.0 0.2 5.4e-144 479.7 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 p450 PF00067.17 CCF37553.1 - 4.2e-47 160.7 0.0 5.7e-47 160.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BolA PF01722.13 CCF37554.1 - 3e-15 55.9 0.0 4.7e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 BolA-like protein COesterase PF00135.23 CCF37555.1 - 1.6e-93 314.2 0.0 2.9e-93 313.4 0.0 1.3 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF37555.1 - 2.8e-05 23.7 0.1 9.9e-05 22.0 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold HTH_psq PF05225.11 CCF37556.1 - 2e-13 49.6 0.0 4.3e-13 48.5 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF37556.1 - 7e-10 38.5 0.1 1.6e-09 37.4 0.0 1.7 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 CCF37556.1 - 1.9e-05 23.9 0.0 3.5e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.1 CCF37556.1 - 0.0043 16.6 0.1 0.041 13.5 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 CCF37556.1 - 0.017 15.1 0.1 0.1 12.6 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Myb_Cef PF11831.3 CCF37559.1 - 0.14 11.3 0.1 0.15 11.2 0.0 1.0 1 0 0 1 1 1 0 pre-mRNA splicing factor component DUF3328 PF11807.3 CCF37562.1 - 1.1e-49 169.0 0.6 1.4e-49 168.6 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) adh_short PF00106.20 CCF37563.1 - 5.2e-16 59.0 0.2 8.8e-16 58.2 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF37563.1 - 1.4e-05 24.8 0.1 2.4e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF37563.1 - 0.029 14.1 0.0 0.048 13.4 0.0 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase CTP_synth_N PF06418.9 CCF37564.1 - 4.7e-82 275.1 0.2 6.4e-82 274.7 0.1 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.23 CCF37564.1 - 1.1e-49 168.5 0.0 1.6e-49 167.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 CCF37564.1 - 5.3e-05 22.7 0.0 0.0001 21.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 Ribonuc_red_lgC PF02867.10 CCF37565.1 - 1.1e-222 740.3 0.0 1.6e-222 739.8 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 CCF37565.1 - 6.1e-25 86.8 0.0 2.3e-23 81.7 0.0 2.5 2 0 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 CCF37565.1 - 6.6e-17 61.7 0.1 2.6e-16 59.8 0.0 2.2 2 0 0 2 2 2 1 ATP cone domain NRDD PF13597.1 CCF37565.1 - 0.09 10.8 0.0 0.16 10.0 0.0 1.3 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase FAD_binding_3 PF01494.14 CCF37566.1 - 2.1e-10 40.2 1.3 5e-09 35.6 0.9 2.5 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 CCF37566.1 - 1.5e-05 24.9 0.0 5.1e-05 23.2 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 CCF37566.1 - 0.025 14.9 0.0 0.051 13.9 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Cg6151-P PF10233.4 CCF37567.1 - 1.9e-36 124.4 13.6 2.3e-36 124.2 9.4 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P YIF1 PF03878.10 CCF37567.1 - 0.11 11.6 4.6 0.15 11.1 3.2 1.1 1 0 0 1 1 1 0 YIF1 PRA1 PF03208.14 CCF37567.1 - 7.7 5.8 10.5 11 5.2 7.3 1.3 1 0 0 1 1 1 0 PRA1 family protein DUF1430 PF07242.6 CCF37567.1 - 8.7 6.4 10.7 3.2 7.8 2.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1430) Sugar_tr PF00083.19 CCF37568.1 - 9.4e-71 238.7 24.0 1.2e-70 238.4 16.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF37568.1 - 4.2e-16 58.6 22.3 4.2e-16 58.6 15.5 2.3 2 1 1 3 3 3 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF37568.1 - 5.1e-14 51.5 16.6 2.2e-08 32.9 2.5 2.6 2 1 0 2 2 2 2 MFS/sugar transport protein DUF1034 PF06280.7 CCF37570.1 - 0.027 14.8 0.1 0.052 13.9 0.0 1.4 1 0 0 1 1 1 0 Fn3-like domain (DUF1034) Herpes_US9 PF06072.6 CCF37570.1 - 0.16 11.8 0.1 0.39 10.5 0.1 1.6 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 EGF_2 PF07974.8 CCF37570.1 - 8.8 6.5 12.1 21 5.4 8.4 1.6 1 0 0 1 1 1 0 EGF-like domain Glyco_hydro_88 PF07470.8 CCF37573.1 - 2.5e-09 36.6 0.5 2.8e-08 33.1 0.6 2.0 2 0 0 2 2 2 1 Glycosyl Hydrolase Family 88 MFS_1 PF07690.11 CCF37574.1 - 3.5e-23 81.8 25.0 3.5e-23 81.8 17.3 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF4538 PF15061.1 CCF37574.1 - 0.056 12.7 0.2 0.59 9.4 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4538) Peptidase_M1 PF01433.15 CCF37575.1 - 4.7e-72 243.2 0.0 6.2e-72 242.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 Leuk-A4-hydro_C PF09127.6 CCF37575.1 - 1.3e-43 147.9 0.0 2.3e-43 147.2 0.0 1.4 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_MA_2 PF13485.1 CCF37575.1 - 1e-17 64.3 0.1 1.8e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase MA superfamily Svf1 PF08622.5 CCF37575.1 - 0.001 18.1 0.0 0.0021 17.0 0.0 1.4 2 0 0 2 2 2 1 Svf1-like Lipoprotein_5 PF01298.13 CCF37575.1 - 0.13 11.2 0.1 0.19 10.6 0.0 1.1 1 0 0 1 1 1 0 Transferrin binding protein-like solute binding protein Peptidase_M61 PF05299.7 CCF37575.1 - 0.16 11.9 2.3 0.9 9.5 1.6 2.2 1 1 0 1 1 1 0 M61 glycyl aminopeptidase APG9 PF04109.11 CCF37576.1 - 9.4e-152 505.1 2.5 1.2e-151 504.7 1.7 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 DUF3694 PF12473.3 CCF37577.1 - 2.7e-45 153.4 0.0 6.1e-45 152.3 0.0 1.6 1 0 0 1 1 1 1 Kinesin protein KIF1B PF12423.3 CCF37577.1 - 2.7e-05 24.0 0.5 2.7e-05 24.0 0.4 2.6 2 0 0 2 2 2 1 Kinesin protein 1B PH PF00169.24 CCF37577.1 - 0.0011 19.1 0.0 0.0073 16.4 0.0 2.3 2 1 0 2 2 2 1 PH domain NHase_beta PF02211.10 CCF37577.1 - 0.011 15.5 2.7 0.024 14.3 1.9 1.5 1 0 0 1 1 1 0 Nitrile hydratase beta subunit OmpH PF03938.9 CCF37577.1 - 0.73 9.7 14.8 1.8 8.4 10.3 1.7 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) MIF4G_like_2 PF09090.6 CCF37577.1 - 7.4 5.7 9.5 41 3.2 6.6 2.2 1 1 0 1 1 1 0 MIF4G like V_ATPase_I PF01496.14 CCF37577.1 - 7.9 4.1 7.6 12 3.6 5.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cyt-b5 PF00173.23 CCF37578.1 - 5.4e-21 74.1 0.2 6e-21 74.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain BRX PF08381.6 CCF37578.1 - 0.0071 15.3 0.6 0.03 13.3 0.4 1.9 1 1 0 1 1 1 1 Transcription factor regulating root and shoot growth via Pin3 YqzH PF14164.1 CCF37578.1 - 0.012 15.4 0.9 0.071 13.0 0.1 2.1 2 1 0 2 2 2 0 YqzH-like protein V-ATPase_H_C PF11698.3 CCF37578.1 - 0.07 13.0 0.0 0.1 12.5 0.0 1.3 1 1 0 1 1 1 0 V-ATPase subunit H DUF3328 PF11807.3 CCF37580.1 - 3.1e-21 76.0 0.3 4.5e-21 75.5 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Myb_DNA-binding PF00249.26 CCF37581.1 - 4.5e-27 93.8 8.7 3.3e-12 46.2 0.0 3.4 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CCF37581.1 - 1.6e-26 92.1 12.7 2e-13 50.2 0.5 3.4 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.6 CCF37581.1 - 0.0039 16.9 2.2 0.29 10.9 0.1 3.5 2 2 1 3 3 3 1 Rap1 Myb domain Nucleoplasmin PF03066.10 CCF37581.1 - 0.013 14.9 4.0 0.025 14.0 2.7 1.4 1 0 0 1 1 1 0 Nucleoplasmin SLIDE PF09111.5 CCF37581.1 - 0.034 13.8 0.0 0.36 10.5 0.0 2.5 2 1 1 3 3 3 0 SLIDE Fe_bilin_red PF05996.7 CCF37581.1 - 0.048 13.1 0.1 0.079 12.4 0.1 1.2 1 0 0 1 1 1 0 Ferredoxin-dependent bilin reductase Daxx PF03344.10 CCF37581.1 - 0.051 12.0 11.6 0.072 11.5 8.0 1.2 1 0 0 1 1 1 0 Daxx Family MADF_DNA_bdg PF10545.4 CCF37581.1 - 0.13 12.4 5.0 1.6 8.9 0.2 3.2 2 1 0 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Rap1_C PF11626.3 CCF37581.1 - 0.25 11.2 3.0 18 5.3 0.1 3.0 1 1 1 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Nop14 PF04147.7 CCF37581.1 - 0.27 9.0 9.9 0.35 8.7 6.9 1.1 1 0 0 1 1 1 0 Nop14-like family Sigma70_ner PF04546.8 CCF37581.1 - 1.1 8.8 7.0 1.8 8.0 4.9 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region NOA36 PF06524.7 CCF37581.1 - 5.7 6.0 10.8 8.7 5.5 7.5 1.2 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.1 CCF37581.1 - 8.5 6.7 18.4 0.13 12.5 5.6 2.8 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Mucin PF01456.12 CCF37583.1 - 0.69 9.6 6.2 0.84 9.4 4.3 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein Xpo1 PF08389.7 CCF37584.1 - 6e-36 123.5 0.3 1.1e-35 122.6 0.2 1.4 1 0 0 1 1 1 1 Exportin 1-like protein TetR_C_3 PF08362.6 CCF37584.1 - 0.042 13.5 0.0 0.36 10.5 0.0 2.0 2 0 0 2 2 2 0 YcdC-like protein, C-terminal region TetR_C_8 PF14278.1 CCF37584.1 - 0.34 11.3 2.5 0.96 9.8 0.0 2.9 3 1 0 3 3 3 0 Transcriptional regulator C-terminal region DUF2347 PF09804.4 CCF37586.1 - 2.5e-110 368.1 0.0 3.3e-110 367.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.1 CCF37586.1 - 3.5e-48 164.0 0.0 5.3e-48 163.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4484) SPA PF08616.5 CCF37586.1 - 3.1e-06 26.8 0.0 6.7e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.4 CCF37586.1 - 0.0012 17.3 0.0 0.016 13.7 0.0 2.2 2 1 0 2 2 2 1 Transport protein Avl9 CENP-B_dimeris PF09026.5 CCF37586.1 - 0.0032 17.6 4.7 0.0088 16.2 3.3 1.7 1 0 0 1 1 1 1 Centromere protein B dimerisation domain DUF4611 PF15387.1 CCF37586.1 - 0.004 17.2 2.3 0.85 9.8 0.9 3.9 4 0 0 4 4 4 1 Domain of unknown function (DUF4611) DUF3727 PF12527.3 CCF37586.1 - 0.013 15.6 2.2 0.026 14.5 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3727) Nro1 PF12753.2 CCF37586.1 - 0.06 12.2 0.8 0.098 11.5 0.6 1.2 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 PBP1_TM PF14812.1 CCF37586.1 - 2.4 8.5 6.5 7.1 7.0 4.5 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AOX PF01786.12 CCF37588.1 - 1.7e-76 256.2 0.0 2.1e-76 255.9 0.0 1.0 1 0 0 1 1 1 1 Alternative oxidase ISK_Channel PF02060.10 CCF37588.1 - 0.11 12.0 0.1 0.23 11.0 0.1 1.5 1 0 0 1 1 1 0 Slow voltage-gated potassium channel Zip PF02535.17 CCF37589.1 - 1.3e-49 168.9 9.8 1.9e-49 168.4 6.8 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter Ribosomal_S19e PF01090.14 CCF37590.1 - 1.1e-57 193.3 0.2 1.3e-57 193.1 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e DUF3648 PF12364.3 CCF37591.1 - 0.12 12.4 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3648) Peptidase_S41 PF03572.13 CCF37593.1 - 1.9e-06 27.3 0.0 4e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase family S41 FAD_binding_4 PF01565.18 CCF37595.1 - 1.6e-24 85.9 3.2 2.9e-24 85.1 2.2 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 CCF37595.1 - 0.0088 15.9 0.0 0.02 14.8 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like Glyco_trans_2_3 PF13632.1 CCF37597.1 - 1.5e-46 158.5 6.6 1.5e-46 158.5 4.6 2.1 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 CCF37597.1 - 7.8e-08 32.3 0.0 1.8e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 CCF37597.1 - 8.3e-06 25.5 0.0 2.4e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 CCF37597.1 - 0.00075 18.8 0.0 0.0017 17.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 21 p450 PF00067.17 CCF37598.1 - 6.1e-45 153.5 0.0 1.5e-44 152.2 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 adh_short PF00106.20 CCF37599.1 - 1.2e-08 35.0 0.1 8e-08 32.3 0.1 2.2 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF37599.1 - 4.1e-06 26.7 0.0 6.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NmrA PF05368.8 CCF37599.1 - 0.0029 16.8 0.1 0.0047 16.1 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.16 CCF37599.1 - 0.019 14.4 0.2 0.11 11.9 0.1 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Dynamitin PF04912.9 CCF37599.1 - 0.033 12.9 0.1 0.049 12.4 0.1 1.2 1 0 0 1 1 1 0 Dynamitin KR PF08659.5 CCF37599.1 - 0.045 13.4 0.1 0.33 10.5 0.0 2.1 2 1 1 3 3 3 0 KR domain DUF2732 PF10809.3 CCF37599.1 - 0.083 12.4 0.0 1.6 8.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2732) KH_5 PF13184.1 CCF37599.1 - 0.22 11.3 1.0 0.39 10.5 0.2 1.7 2 0 0 2 2 2 0 NusA-like KH domain Aldedh PF00171.17 CCF37600.1 - 8.5e-15 54.0 8.6 3.4e-10 38.8 3.5 2.7 2 1 0 2 2 2 2 Aldehyde dehydrogenase family RNase_PH PF01138.16 CCF37603.1 - 2.7e-36 124.8 0.1 4e-36 124.2 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Thioredoxin PF00085.15 CCF37604.1 - 1.5e-35 121.0 0.2 1.9e-27 94.9 0.0 2.7 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.1 CCF37604.1 - 2.9e-15 56.5 0.0 6e-06 26.1 0.0 3.2 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.1 CCF37604.1 - 1.4e-08 34.9 0.7 0.0012 18.9 0.2 3.3 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 CCF37604.1 - 3.4e-07 30.3 0.1 0.0043 17.1 0.0 4.3 3 2 1 4 4 4 1 Thioredoxin-like ERp29_N PF07912.8 CCF37604.1 - 0.00013 21.9 0.0 0.63 9.9 0.0 2.4 1 1 1 2 2 2 2 ERp29, N-terminal domain Thioredoxin_7 PF13899.1 CCF37604.1 - 0.0019 18.2 0.0 0.0046 16.9 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_3 PF13192.1 CCF37604.1 - 0.002 17.8 0.0 0.27 11.0 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin domain AhpC-TSA PF00578.16 CCF37604.1 - 0.0045 16.6 0.1 0.88 9.2 0.0 2.4 2 0 0 2 2 2 1 AhpC/TSA family HyaE PF07449.6 CCF37604.1 - 0.0046 16.8 0.0 4.7 7.1 0.0 3.4 2 1 0 2 2 2 1 Hydrogenase-1 expression protein HyaE DUF2360 PF10152.4 CCF37604.1 - 0.05 13.9 7.5 0.75 10.0 0.9 2.3 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) Cellulase PF00150.13 CCF37606.1 - 3.2e-20 72.4 0.1 6e-20 71.5 0.1 1.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) zf-CCCH PF00642.19 CCF37607.1 - 1.1e-05 24.9 3.1 2e-05 24.1 2.2 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Adeno_PV PF03910.8 CCF37607.1 - 0.14 11.1 0.3 0.17 10.9 0.2 1.1 1 0 0 1 1 1 0 Adenovirus minor core protein PV zf-CCCH_2 PF14608.1 CCF37607.1 - 0.18 11.8 2.7 0.5 10.4 1.9 1.8 1 1 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type Dimerisation PF08100.6 CCF37608.1 - 0.14 11.9 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Dimerisation domain SBF PF01758.11 CCF37609.1 - 9.2e-49 165.3 11.8 9.2e-49 165.3 8.2 2.1 2 0 0 2 2 2 1 Sodium Bile acid symporter family Fungal_trans_2 PF11951.3 CCF37610.1 - 6.7e-10 38.1 0.1 1.1e-09 37.3 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF37610.1 - 1.1e-06 28.3 12.3 2.4e-06 27.3 8.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF37611.1 - 5.4e-16 58.2 0.3 1e-15 57.3 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF37611.1 - 4.4e-07 29.6 8.6 7.7e-07 28.9 6.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_20 PF00728.17 CCF37612.1 - 2.6e-39 135.3 0.0 3.5e-39 134.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.10 CCF37612.1 - 1.3e-07 32.2 0.0 5e-07 30.2 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 Rhomboid PF01694.17 CCF37613.1 - 1.2e-35 122.6 10.2 1.2e-35 122.6 7.1 2.5 3 0 0 3 3 3 1 Rhomboid family DNA_pol_B PF00136.16 CCF37614.1 - 3.4e-147 490.9 5.5 5.4e-147 490.3 3.8 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 CCF37614.1 - 3.9e-79 265.8 0.5 1.2e-78 264.2 0.0 2.0 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 CCF37614.1 - 2.9e-23 81.6 5.8 7.6e-23 80.3 4.0 1.8 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta RNase_H_2 PF13482.1 CCF37614.1 - 3.7e-05 23.5 0.1 0.0002 21.1 0.1 2.4 1 1 0 1 1 1 1 RNase_H superfamily DNA_pol_B_exo2 PF10108.4 CCF37614.1 - 0.00043 19.8 0.0 0.00088 18.8 0.0 1.4 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB C1_1 PF00130.17 CCF37614.1 - 0.017 14.8 0.8 0.017 14.8 0.5 2.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ELFV_dehydrog PF00208.16 CCF37615.1 - 1.5e-85 286.6 4.8 1.9e-85 286.3 3.3 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.13 CCF37615.1 - 6e-49 164.9 0.0 1.8e-48 163.4 0.0 1.8 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NAD_binding_7 PF13241.1 CCF37615.1 - 0.022 15.0 0.1 0.072 13.3 0.0 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding Glyco_hydro_16 PF00722.16 CCF37616.1 - 9.4e-12 44.5 0.5 1.3e-11 44.1 0.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 NTP_transferase PF00483.18 CCF37618.1 - 1.4e-29 103.1 0.0 1.7e-29 102.8 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.19 CCF37618.1 - 7.6e-09 34.6 7.7 5.5e-06 25.6 0.1 3.8 3 1 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 CCF37618.1 - 2e-06 27.9 0.0 3.1e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.7 CCF37618.1 - 0.043 12.3 0.1 0.46 8.9 0.0 2.4 2 1 1 3 3 3 0 L-fucokinase TRAPPC-Trs85 PF12739.2 CCF37619.1 - 3.4e-116 388.2 0.2 5.8e-116 387.5 0.1 1.3 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Baculo_LEF-11 PF06385.7 CCF37619.1 - 0.11 12.5 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Baculovirus LEF-11 protein Snf7 PF03357.16 CCF37620.1 - 8.6e-17 61.0 14.6 8.7e-17 61.0 9.1 1.7 1 1 0 1 1 1 1 Snf7 Glyco_hydro_28 PF00295.12 CCF37621.1 - 8.8e-31 107.0 0.4 5.3e-29 101.2 0.1 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 28 Beta_helix PF13229.1 CCF37621.1 - 0.00061 19.5 5.5 0.0013 18.4 1.1 2.9 2 1 0 2 2 2 1 Right handed beta helix region PKD_channel PF08016.7 CCF37623.1 - 0.00081 17.9 5.7 0.055 11.8 0.4 2.2 2 0 0 2 2 2 2 Polycystin cation channel Fasciclin PF02469.17 CCF37625.1 - 9.1e-45 151.7 6.1 7.3e-24 84.2 0.7 2.1 2 0 0 2 2 2 2 Fasciclin domain AA_permease_2 PF13520.1 CCF37626.1 - 3.2e-54 184.0 21.9 3.6e-54 183.9 15.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF37626.1 - 5.8e-08 31.5 19.9 7.5e-08 31.1 13.8 1.1 1 0 0 1 1 1 1 Amino acid permease Aa_trans PF01490.13 CCF37626.1 - 4.6e-05 22.0 9.5 6.1e-05 21.6 6.6 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein LysM PF01476.15 CCF37627.1 - 3.9e-13 49.0 0.1 2.9e-07 30.2 0.0 2.2 2 0 0 2 2 2 2 LysM domain HTH_Tnp_1 PF01527.15 CCF37627.1 - 0.00068 19.5 0.0 0.057 13.3 0.0 2.2 2 0 0 2 2 2 2 Transposase HTH_23 PF13384.1 CCF37627.1 - 0.0056 16.2 0.0 0.44 10.2 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain Herpes_UL92 PF03048.9 CCF37627.1 - 0.036 13.6 0.4 6.7 6.2 0.0 2.2 2 0 0 2 2 2 0 UL92 family zf-met PF12874.2 CCF37629.1 - 0.11 12.7 1.0 0.34 11.1 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger of C2H2 type CFEM PF05730.6 CCF37630.1 - 8.7e-11 41.4 11.9 1.1e-10 41.1 8.2 1.1 1 0 0 1 1 1 1 CFEM domain Gamma-thionin PF00304.15 CCF37630.1 - 0.56 10.2 6.0 0.27 11.2 1.4 2.0 2 0 0 2 2 2 0 Gamma-thionin family LMWPc PF01451.16 CCF37631.1 - 1.5e-36 125.7 0.0 1.7e-36 125.5 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase p450 PF00067.17 CCF37633.1 - 4.5e-51 173.8 0.0 5.9e-51 173.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 CCF37634.1 - 1.9e-66 224.5 0.0 2.6e-66 224.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 HAMP PF00672.20 CCF37634.1 - 0.42 10.8 5.6 0.35 11.0 2.4 2.0 2 0 0 2 2 2 0 HAMP domain adh_short PF00106.20 CCF37635.1 - 4.3e-28 98.3 4.7 5.4e-28 97.9 3.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF37635.1 - 6.2e-25 88.3 0.0 8e-25 87.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF37635.1 - 2.9e-14 53.1 4.2 4.1e-14 52.6 2.9 1.2 1 0 0 1 1 1 1 KR domain APH PF01636.18 CCF37636.1 - 2.2e-09 37.4 0.9 1.8e-08 34.4 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Cyclase PF04199.8 CCF37637.1 - 0.017 14.7 0.1 0.028 14.1 0.1 1.3 1 1 0 1 1 1 0 Putative cyclase DHDPS PF00701.17 CCF37638.1 - 3.9e-28 97.8 0.0 4.4e-28 97.7 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Amidohydro_3 PF07969.6 CCF37638.1 - 0.0063 15.7 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase family DUF818 PF05677.7 CCF37638.1 - 0.071 11.8 0.0 0.1 11.3 0.0 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Aldo_ket_red PF00248.16 CCF37639.1 - 8.1e-51 172.4 0.0 1e-50 172.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DapB_N PF01113.15 CCF37639.1 - 0.1 12.5 0.2 7.7 6.4 0.0 2.3 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Complex1_LYR_2 PF13233.1 CCF37641.1 - 3.8e-19 69.1 0.0 4.4e-19 68.8 0.0 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Syja_N PF02383.13 CCF37642.1 - 1e-09 37.5 0.0 1.2e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain Ribosomal_L7Ae PF01248.21 CCF37643.1 - 1.4e-24 85.3 0.1 1.9e-24 85.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 CCF37643.1 - 0.0034 17.2 0.0 0.0034 17.2 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.1 CCF37643.1 - 0.0055 16.4 0.0 0.0064 16.2 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain ATP-synt_C PF00137.16 CCF37644.1 - 4.1e-31 106.6 30.0 1.4e-18 66.5 8.6 2.1 2 0 0 2 2 2 2 ATP synthase subunit C ABA_GPCR PF12430.3 CCF37644.1 - 0.18 10.8 0.9 2.8 7.0 0.1 2.1 2 0 0 2 2 2 0 Abscisic acid G-protein coupled receptor Flavi_NS4A PF01350.12 CCF37644.1 - 0.72 9.3 6.1 0.18 11.3 1.7 1.7 2 0 0 2 2 2 0 Flavivirus non-structural protein NS4A DUF2970 PF11174.3 CCF37644.1 - 3.4 7.3 9.9 0.45 10.1 0.9 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) DUF791 PF05631.9 CCF37647.1 - 2e-09 36.6 2.6 2.4e-09 36.3 1.7 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF791) MFS_1 PF07690.11 CCF37647.1 - 0.0066 15.2 8.3 0.012 14.3 5.7 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3429 PF11911.3 CCF37647.1 - 0.035 14.0 2.5 0.064 13.2 1.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3429) DUF1686 PF07937.6 CCF37647.1 - 0.18 11.3 2.2 4.3 6.9 0.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1686) Polysacc_synt PF01943.12 CCF37647.1 - 0.27 10.4 4.2 0.37 10.0 2.9 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF3792 PF12670.2 CCF37647.1 - 3.5 7.5 8.3 4.7 7.1 3.9 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3792) DDE_1 PF03184.14 CCF37649.1 - 2.9e-35 121.3 0.0 1.2e-34 119.3 0.0 1.9 1 1 0 1 1 1 1 DDE superfamily endonuclease adh_short PF00106.20 CCF37650.1 - 4.2e-31 108.1 0.3 5e-31 107.8 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF37650.1 - 7.7e-15 55.3 0.1 1e-14 54.9 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF37650.1 - 1.1e-14 54.5 0.4 1.6e-14 53.9 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF37650.1 - 1.6e-05 24.4 0.1 2.7e-05 23.7 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF37650.1 - 2.9e-05 24.1 0.5 8.5e-05 22.6 0.3 1.8 1 1 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 CCF37650.1 - 0.0073 15.2 0.0 0.011 14.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.3 CCF37650.1 - 0.066 12.9 0.2 0.19 11.5 0.1 1.8 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase HSP70 PF00012.15 CCF37651.1 - 1.6e-60 204.6 15.0 8.1e-57 192.4 0.5 2.8 2 1 1 3 3 3 3 Hsp70 protein MreB_Mbl PF06723.8 CCF37651.1 - 0.0039 15.8 0.4 0.01 14.4 0.0 1.8 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 CCF37651.1 - 0.0047 16.5 0.7 0.013 15.1 0.2 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FTA4 PF13093.1 CCF37651.1 - 0.021 14.2 0.7 0.038 13.4 0.5 1.5 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 EMP70 PF02990.11 CCF37652.1 - 1.4e-23 83.1 0.0 1.9e-23 82.7 0.0 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 Bul1_N PF04425.7 CCF37654.1 - 3.2e-05 22.6 1.7 0.0084 14.7 0.3 3.0 2 1 1 3 3 3 2 Bul1 N terminus Arrestin_N PF00339.24 CCF37654.1 - 5e-05 23.1 0.0 0.00039 20.2 0.0 2.4 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Bul1_C PF04426.7 CCF37654.1 - 0.00019 20.7 0.0 0.00035 19.8 0.0 1.4 1 0 0 1 1 1 1 Bul1 C terminus Epimerase PF01370.16 CCF37656.1 - 4e-11 42.8 0.0 5.2e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF37656.1 - 2.9e-08 32.7 0.0 3.7e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 CCF37656.1 - 1.3e-06 28.5 0.1 4e-06 26.9 0.1 1.8 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 CCF37656.1 - 5.4e-05 22.2 0.1 0.04 12.8 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein adh_short PF00106.20 CCF37656.1 - 0.00014 21.8 0.2 0.00028 20.8 0.1 1.7 1 1 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.10 CCF37656.1 - 0.00085 18.2 0.0 0.001 18.0 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.8 CCF37656.1 - 0.001 18.3 0.0 0.0016 17.7 0.0 1.3 1 1 0 1 1 1 1 NmrA-like family Cutinase PF01083.17 CCF37658.1 - 5.8e-46 156.4 1.3 6.7e-46 156.2 0.9 1.0 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.6 CCF37658.1 - 1.7e-05 24.3 0.0 2.5e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 PE-PPE domain Abhydrolase_1 PF00561.15 CCF37658.1 - 0.031 13.8 0.0 0.047 13.2 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 CCF37658.1 - 0.031 13.7 0.0 0.09 12.2 0.0 1.7 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase VirJ PF06057.6 CCF37658.1 - 0.049 13.4 0.0 0.073 12.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Ferric_reduct PF01794.14 CCF37659.1 - 1.5e-15 57.3 10.2 1.5e-15 57.3 7.1 2.3 1 1 1 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 CCF37659.1 - 0.00024 20.9 0.0 0.0056 16.5 0.0 2.5 3 0 0 3 3 3 1 FAD-binding domain DUF4405 PF14358.1 CCF37659.1 - 7.3 6.8 14.1 2.5 8.3 0.5 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4405) MARVEL PF01284.18 CCF37660.1 - 4.8e-07 29.7 4.0 5.7e-07 29.4 2.8 1.2 1 0 0 1 1 1 1 Membrane-associating domain DUF2306 PF10067.4 CCF37660.1 - 0.091 12.8 3.5 0.066 13.3 0.9 1.8 1 1 1 2 2 2 0 Predicted membrane protein (DUF2306) FA_desaturase PF00487.19 CCF37660.1 - 0.45 9.8 6.7 0.72 9.2 4.7 1.4 1 1 0 1 1 1 0 Fatty acid desaturase YqhR PF11085.3 CCF37660.1 - 1.7 8.1 9.0 2.2 7.7 6.2 1.2 1 0 0 1 1 1 0 Conserved membrane protein YqhR BAR PF03114.13 CCF37662.1 - 1.3e-13 51.0 0.2 2.3e-13 50.2 0.1 1.4 2 0 0 2 2 2 1 BAR domain SH3_9 PF14604.1 CCF37662.1 - 7.4e-11 41.4 0.2 1.4e-10 40.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 CCF37662.1 - 1.6e-09 36.9 0.2 3e-09 36.1 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 CCF37662.1 - 4.1e-09 35.7 0.2 7.2e-09 35.0 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain TPR_14 PF13428.1 CCF37662.1 - 0.081 13.6 0.4 0.7 10.6 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2439 PF10382.4 CCF37664.1 - 2.3e-28 98.2 0.2 3.4e-28 97.6 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) DUF2477 PF10631.4 CCF37664.1 - 0.13 12.5 0.8 0.21 11.8 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2477) LysM PF01476.15 CCF37665.1 - 7.1e-16 57.8 0.3 0.00059 19.6 0.0 4.3 5 0 0 5 5 5 3 LysM domain ETF_alpha PF00766.14 CCF37665.1 - 0.58 9.8 2.8 20 4.8 0.2 2.4 2 0 0 2 2 2 0 Electron transfer flavoprotein FAD-binding domain TAA-Trp-ring PF15401.1 CCF37665.1 - 9.4 6.5 9.1 7.5 6.8 0.1 3.2 3 0 0 3 3 3 0 Tryptophan-ring motif of head of Trimeric autotransporter adhesin Glyco_hydro_18 PF00704.23 CCF37666.1 - 8e-70 235.9 1.2 1.3e-69 235.2 0.8 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.14 CCF37666.1 - 1.2e-07 31.5 17.0 1.2e-07 31.5 11.8 4.3 4 0 0 4 4 4 2 Chitin recognition protein Aldo_ket_red PF00248.16 CCF37667.1 - 8e-54 182.3 0.0 9e-54 182.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HAD_2 PF13419.1 CCF37667.1 - 0.024 14.8 0.0 0.05 13.8 0.0 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Pkinase PF00069.20 CCF37668.1 - 1.5e-62 211.1 0.0 2.2e-62 210.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF37668.1 - 2.4e-37 128.4 0.0 3.4e-37 127.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF37668.1 - 3.9e-11 42.4 0.0 9.7e-10 37.8 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 CCF37668.1 - 0.0043 16.8 3.7 0.023 14.4 0.0 2.9 3 1 0 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.9 CCF37668.1 - 0.0073 15.3 0.0 0.016 14.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 CCF37668.1 - 0.085 11.6 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Peptidase_M16_C PF05193.16 CCF37671.1 - 1.3e-17 64.0 0.0 5.8e-13 48.9 0.0 2.6 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 CCF37671.1 - 1.5e-05 24.8 0.1 6.7e-05 22.6 0.0 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) M16C_assoc PF08367.6 CCF37671.1 - 0.5 9.1 2.2 15 4.3 0.0 2.4 2 0 0 2 2 2 0 Peptidase M16C associated Sporozoite_P67 PF05642.6 CCF37671.1 - 0.56 8.0 6.0 0.82 7.4 4.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen HeLo PF14479.1 CCF37672.1 - 4.4e-34 118.0 0.1 7.7e-34 117.3 0.1 1.3 1 1 0 1 1 1 1 Prion-inhibition and propagation ETX_MTX2 PF03318.8 CCF37673.1 - 0.0035 16.9 1.7 0.0063 16.0 1.2 1.3 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 PAP1 PF08601.5 CCF37676.1 - 0.27 10.8 3.4 0.37 10.4 2.4 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 WD40 PF00400.27 CCF37677.1 - 0.0084 15.9 0.3 0.14 12.1 0.0 2.9 3 0 0 3 3 3 1 WD domain, G-beta repeat Nup160 PF11715.3 CCF37677.1 - 0.0092 14.1 0.0 0.0097 14.0 0.0 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 CCF37677.1 - 0.095 11.4 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 Nup133 N terminal like INSIG PF07281.7 CCF37678.1 - 2.7e-53 180.1 0.6 3.5e-53 179.8 0.4 1.1 1 0 0 1 1 1 1 Insulin-induced protein (INSIG) p450 PF00067.17 CCF37679.1 - 5.4e-29 101.0 0.0 6.2e-29 100.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SMC_N PF02463.14 CCF37681.1 - 1.2e-12 47.5 0.4 2e-12 46.8 0.3 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 CCF37681.1 - 0.0002 21.2 0.0 0.00043 20.2 0.0 1.5 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain SbcCD_C PF13558.1 CCF37681.1 - 0.0045 16.8 0.0 0.012 15.5 0.0 1.7 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit GAGA_bind PF06217.7 CCF37681.1 - 0.091 12.7 7.6 0.15 11.9 5.2 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family COQ9 PF08511.6 CCF37682.1 - 1.1e-27 95.3 0.0 1.6e-27 94.8 0.0 1.3 1 0 0 1 1 1 1 COQ9 DUF4231 PF14015.1 CCF37685.1 - 0.5 10.3 4.5 4.9 7.1 1.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) MFS_1 PF07690.11 CCF37688.1 - 1.5e-06 27.1 3.9 1.5e-06 27.1 2.7 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily DsbB PF02600.11 CCF37688.1 - 2.1 8.1 8.4 1.9 8.2 3.6 2.4 2 1 1 3 3 3 0 Disulfide bond formation protein DsbB zf-C2H2_4 PF13894.1 CCF37690.1 - 0.022 15.0 1.5 0.022 15.0 1.0 3.2 4 1 0 4 4 4 0 C2H2-type zinc finger MFS_1 PF07690.11 CCF37691.1 - 3.2e-41 141.2 49.2 4.2e-39 134.2 34.1 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF37691.1 - 1.7e-11 43.3 13.2 1.7e-11 43.3 9.1 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter ThiF PF00899.16 CCF37692.1 - 3.2e-11 43.1 0.0 3.8e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 ThiF family NUDIX PF00293.23 CCF37693.1 - 3.1e-28 98.1 0.0 4.4e-28 97.5 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain MatE PF01554.13 CCF37694.1 - 3.3e-53 179.6 28.7 2.4e-29 102.0 7.6 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.1 CCF37694.1 - 0.0072 16.1 8.8 0.0072 16.1 6.1 3.9 3 2 1 4 4 4 1 Polysaccharide biosynthesis C-terminal domain Form-deh_trans PF09163.6 CCF37694.1 - 0.014 14.9 0.1 0.045 13.2 0.1 1.9 1 0 0 1 1 1 0 Formate dehydrogenase N, transmembrane F-box-like PF12937.2 CCF37695.1 - 0.063 13.0 0.4 3.8 7.2 0.0 3.1 3 0 0 3 3 3 0 F-box-like Ribosomal_L22 PF00237.14 CCF37696.1 - 3.7e-34 116.8 0.0 5.4e-34 116.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Amidohydro_2 PF04909.9 CCF37698.1 - 4.3e-20 72.4 0.2 5e-20 72.1 0.2 1.1 1 0 0 1 1 1 1 Amidohydrolase CHD5 PF04420.9 CCF37699.1 - 4.4e-56 189.0 1.4 5.8e-56 188.6 1.0 1.1 1 0 0 1 1 1 1 CHD5-like protein DUF747 PF05346.6 CCF37699.1 - 0.069 12.1 0.0 0.073 12.1 0.0 1.3 1 1 0 1 1 1 0 Eukaryotic membrane protein family Peptidase_S49_N PF08496.5 CCF37699.1 - 0.091 12.5 1.9 0.27 11.0 0.2 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Neisseria_TspB PF05616.8 CCF37701.1 - 0.12 10.6 0.0 0.14 10.5 0.0 1.0 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein COesterase PF00135.23 CCF37702.1 - 2.2e-50 171.9 0.0 2.7e-50 171.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF37702.1 - 0.00015 21.4 0.1 0.00049 19.7 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF37702.1 - 0.0024 17.1 0.4 0.025 13.8 0.1 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CCF37702.1 - 0.0045 16.7 0.2 0.02 14.6 0.1 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Esterase_phd PF10503.4 CCF37702.1 - 0.019 14.1 0.6 0.04 13.1 0.2 1.5 1 1 0 1 1 1 0 Esterase PHB depolymerase Esterase PF00756.15 CCF37702.1 - 0.12 11.7 0.3 0.2 11.0 0.0 1.4 2 0 0 2 2 2 0 Putative esterase B_lectin PF01453.19 CCF37703.1 - 0.0002 21.1 0.3 0.0067 16.3 0.2 2.3 1 1 0 1 1 1 1 D-mannose binding lectin XPG_I_2 PF12813.2 CCF37704.1 - 5.6e-32 111.1 0.0 1.6e-31 109.6 0.0 1.7 1 1 1 2 2 2 1 XPG domain containing XPG_I PF00867.13 CCF37704.1 - 0.026 14.5 0.0 0.1 12.6 0.0 2.0 2 1 0 2 2 2 0 XPG I-region Pribosyltran_N PF13793.1 CCF37706.1 - 5.3e-42 142.2 0.2 6.9e-40 135.4 0.0 2.4 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 CCF37706.1 - 2.9e-34 118.4 0.1 1e-28 100.3 0.0 2.3 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 CCF37706.1 - 3.2e-05 23.6 0.3 0.0023 17.6 0.0 2.8 3 0 0 3 3 3 1 Phosphoribosyl transferase domain PAP_assoc PF03828.14 CCF37707.1 - 1.8e-17 63.0 0.0 1e-11 44.6 0.0 2.5 2 0 0 2 2 2 2 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 CCF37707.1 - 0.0089 16.3 0.0 0.021 15.1 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain DUF3405 PF11885.3 CCF37709.1 - 4.3e-169 562.8 0.7 8.4e-169 561.9 0.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) Ytp1 PF10355.4 CCF37710.1 - 4.8e-81 271.9 14.7 4.8e-81 271.9 10.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.4 CCF37710.1 - 1.1e-32 111.7 4.4 1.1e-32 111.7 3.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) FliG_C PF01706.11 CCF37711.1 - 0.12 12.3 1.1 0.18 11.7 0.5 1.5 1 1 0 1 1 1 0 FliG C-terminal domain Myosin_head PF00063.16 CCF37714.1 - 2.9e-241 802.3 0.1 5.5e-241 801.4 0.0 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.22 CCF37714.1 - 9.1e-22 74.5 32.6 1.5e-06 27.3 0.7 6.8 6 0 0 6 6 6 5 IQ calmodulin-binding motif Reo_sigmaC PF04582.7 CCF37714.1 - 9.8e-05 21.6 0.3 0.00017 20.8 0.2 1.5 1 0 0 1 1 1 1 Reovirus sigma C capsid protein AAA_22 PF13401.1 CCF37714.1 - 0.00039 20.5 0.1 0.0016 18.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain Baculo_PEP_C PF04513.7 CCF37714.1 - 0.00064 19.5 3.7 0.0016 18.2 2.6 1.8 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus GAS PF13851.1 CCF37714.1 - 0.0018 17.5 18.3 0.0037 16.5 12.7 1.6 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding AAA_19 PF13245.1 CCF37714.1 - 0.0023 17.6 0.0 0.012 15.3 0.0 2.3 2 0 0 2 2 2 1 Part of AAA domain AAA_16 PF13191.1 CCF37714.1 - 0.0073 16.3 0.0 0.026 14.5 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain FlaC_arch PF05377.6 CCF37714.1 - 0.014 15.2 7.6 0.019 14.8 0.1 3.4 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) AAA_10 PF12846.2 CCF37714.1 - 0.025 14.0 0.2 0.11 11.9 0.0 2.2 2 0 0 2 2 2 0 AAA-like domain Myosin_N PF02736.14 CCF37714.1 - 0.13 11.9 3.9 0.058 13.0 0.6 2.1 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain IncA PF04156.9 CCF37714.1 - 0.14 11.7 16.1 0.39 10.3 11.2 1.8 1 0 0 1 1 1 0 IncA protein BRE1 PF08647.6 CCF37714.1 - 3.2 7.7 17.0 2.4 8.1 3.4 3.0 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase EMP24_GP25L PF01105.19 CCF37714.1 - 4.5 6.9 13.5 1.3 8.6 5.1 2.4 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD Seryl_tRNA_N PF02403.17 CCF37714.1 - 5.1 7.1 21.5 0.7 9.9 6.0 3.7 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 PF07926.7 CCF37714.1 - 5.9 6.6 21.6 1 9.1 11.6 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Pkinase PF00069.20 CCF37715.1 - 2.3e-66 223.5 0.0 4e-66 222.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF37715.1 - 6.7e-48 163.0 0.0 1e-47 162.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF37715.1 - 8.1e-10 38.1 0.0 7.2e-08 31.7 0.0 2.1 1 1 0 2 2 2 2 Kinase-like Kdo PF06293.9 CCF37715.1 - 0.001 18.2 0.0 0.0056 15.7 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CCF37715.1 - 0.057 13.1 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family TPR_12 PF13424.1 CCF37716.1 - 1.3e-08 34.6 0.1 1.6e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.1 CCF37716.1 - 6.1e-05 22.8 0.8 0.0024 17.7 0.1 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 CCF37716.1 - 0.017 14.7 0.2 0.034 13.7 0.1 1.6 1 1 1 2 2 2 0 TPR repeat TPR_19 PF14559.1 CCF37716.1 - 0.098 13.0 0.0 0.38 11.1 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Coatomer_E PF04733.9 CCF37716.1 - 0.1 11.7 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Coatomer epsilon subunit PFK PF00365.15 CCF37719.1 - 3.4e-29 101.7 0.0 4.3e-29 101.3 0.0 1.1 1 0 0 1 1 1 1 Phosphofructokinase TerB-C PF15615.1 CCF37719.1 - 0.12 12.6 0.0 0.25 11.5 0.0 1.5 1 1 0 1 1 1 0 TerB-C domain FAD_binding_1 PF00667.15 CCF37720.1 - 6.4e-43 146.7 0.0 8.8e-43 146.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 CCF37720.1 - 2.2e-09 37.8 0.0 4.5e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain RVT_1 PF00078.22 CCF37721.1 - 9e-09 34.9 0.0 1.7e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FdsD PF11390.3 CCF37721.1 - 0.052 13.6 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 NADH-dependant formate dehydrogenase delta subunit FdsD AA_synth PF06684.6 CCF37721.1 - 0.088 12.1 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Amino acid synthesis UPF0122 PF04297.9 CCF37721.1 - 0.11 12.5 0.3 0.28 11.2 0.0 1.7 2 0 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like MFS_1 PF07690.11 CCF37722.1 - 4.2e-43 147.4 41.9 4.2e-43 147.4 29.1 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF37722.1 - 1.4e-14 53.5 11.2 1.4e-14 53.5 7.8 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 CCF37722.1 - 4e-07 28.6 13.2 9.1e-07 27.4 9.1 1.6 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) AKAP28 PF14469.1 CCF37722.1 - 0.12 11.9 0.4 0.22 11.1 0.3 1.3 1 0 0 1 1 1 0 28 kDa A-kinase anchor AMP-binding PF00501.23 CCF37723.1 - 4.5e-15 54.9 0.2 6.6e-15 54.4 0.2 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Hepatitis_core PF00906.15 CCF37723.1 - 0.13 11.9 0.0 0.36 10.4 0.0 1.7 1 0 0 1 1 1 0 Hepatitis core antigen NPCC PF08058.6 CCF37724.1 - 7.6e-30 103.6 0.1 5.4e-29 100.9 0.1 2.0 1 1 0 1 1 1 1 Nuclear pore complex component Hid1 PF12722.2 CCF37725.1 - 1.6e-239 797.1 0.0 1.9e-239 796.8 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.4 CCF37725.1 - 1.6e-81 274.4 0.0 2.3e-81 273.8 0.0 1.3 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Response_reg PF00072.19 CCF37726.1 - 5.9e-21 74.5 0.0 1.4e-20 73.3 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.21 CCF37726.1 - 5.1e-20 71.2 0.1 1.2e-19 70.0 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 CCF37726.1 - 3.6e-12 46.0 0.0 1.3e-11 44.2 0.0 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Ank_2 PF12796.2 CCF37728.1 - 8.4e-15 54.8 0.1 2.4e-07 31.0 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 CCF37728.1 - 1.2e-13 50.1 3.8 1.1e-07 31.2 0.2 3.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 CCF37728.1 - 3.4e-13 49.3 5.6 1.4e-08 34.6 0.4 3.4 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 CCF37728.1 - 5e-12 45.9 3.0 5e-05 23.6 0.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF37728.1 - 1.3e-09 37.3 0.3 0.00048 20.1 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Amido_AtzD_TrzD PF09663.5 CCF37728.1 - 0.02 13.5 0.3 0.025 13.1 0.2 1.1 1 0 0 1 1 1 0 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD) Lentiviral_Tat PF02998.9 CCF37728.1 - 0.039 13.7 0.1 0.29 10.9 0.0 2.0 2 0 0 2 2 2 0 Lentiviral Tat protein HALZ PF02183.13 CCF37730.1 - 7.9e-05 22.2 8.0 0.00097 18.8 1.2 2.5 2 0 0 2 2 2 2 Homeobox associated leucine zipper RRM_6 PF14259.1 CCF37730.1 - 0.00098 19.0 0.0 0.0022 17.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF904 PF06005.7 CCF37730.1 - 0.002 18.3 10.9 0.15 12.3 2.6 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF904) bZIP_1 PF00170.16 CCF37730.1 - 0.02 14.8 1.7 0.02 14.8 1.2 2.0 2 0 0 2 2 1 0 bZIP transcription factor NPV_P10 PF05531.7 CCF37730.1 - 0.02 15.1 3.6 0.027 14.7 0.3 2.7 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Tropomyosin PF00261.15 CCF37730.1 - 0.051 12.6 9.8 0.31 10.1 6.8 1.9 1 1 0 1 1 1 0 Tropomyosin DUF3450 PF11932.3 CCF37730.1 - 0.067 12.4 3.7 0.052 12.8 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF972 PF06156.8 CCF37730.1 - 0.07 13.4 5.2 0.58 10.5 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF972) BLOC1_2 PF10046.4 CCF37730.1 - 0.092 12.8 4.7 0.58 10.3 1.5 2.7 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Snapin_Pallidin PF14712.1 CCF37730.1 - 0.11 12.8 4.6 1.7 9.0 0.1 2.6 2 0 0 2 2 2 0 Snapin/Pallidin TMF_DNA_bd PF12329.3 CCF37730.1 - 0.11 12.2 9.4 0.31 10.8 2.9 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Rab5-bind PF09311.6 CCF37730.1 - 0.12 12.2 10.8 0.26 11.1 7.5 1.5 1 0 0 1 1 1 0 Rabaptin-like protein Lge1 PF11488.3 CCF37730.1 - 0.14 12.3 3.1 0.16 12.1 0.2 2.4 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 CENP-F_leu_zip PF10473.4 CCF37730.1 - 0.14 11.9 11.1 2.5 7.9 6.6 2.9 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ERM PF00769.14 CCF37730.1 - 0.16 11.4 8.7 0.37 10.2 5.5 1.9 1 1 1 2 2 2 0 Ezrin/radixin/moesin family TMF_TATA_bd PF12325.3 CCF37730.1 - 0.21 11.3 7.4 61 3.3 0.8 2.3 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding GAS PF13851.1 CCF37730.1 - 0.3 10.2 7.9 0.47 9.6 4.2 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DivIVA PF05103.8 CCF37730.1 - 0.46 10.5 5.3 0.76 9.8 2.9 1.9 1 1 1 2 2 2 0 DivIVA protein ADIP PF11559.3 CCF37730.1 - 0.49 10.2 13.6 0.096 12.5 4.4 2.3 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF2205 PF10224.4 CCF37730.1 - 0.83 9.2 5.8 0.27 10.8 0.6 2.3 2 0 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) DUF4201 PF13870.1 CCF37730.1 - 1.5 8.2 9.0 12 5.3 5.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Laminin_II PF06009.7 CCF37730.1 - 1.6 8.4 7.0 0.38 10.5 0.8 2.5 3 0 0 3 3 3 0 Laminin Domain II IncA PF04156.9 CCF37730.1 - 1.8 8.1 14.2 5.2 6.6 9.8 1.7 1 1 0 1 1 1 0 IncA protein DivIC PF04977.10 CCF37730.1 - 1.9 8.0 6.7 1.3 8.5 0.7 2.6 2 0 0 2 2 2 0 Septum formation initiator Uds1 PF15456.1 CCF37730.1 - 4.3 7.3 8.6 22 5.0 5.7 2.2 1 1 1 2 2 2 0 Up-regulated During Septation Chromo PF00385.19 CCF37731.1 - 3.6e-08 32.9 0.1 3.6e-08 32.9 0.1 1.6 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain DAP PF15228.1 CCF37731.1 - 0.077 13.7 0.1 0.18 12.5 0.1 1.6 1 0 0 1 1 1 0 Death-associated protein Myc_N PF01056.13 CCF37731.1 - 0.078 12.1 2.6 0.041 13.0 0.4 1.6 2 0 0 2 2 2 0 Myc amino-terminal region BSP_II PF05432.6 CCF37731.1 - 0.36 10.0 7.6 0.32 10.2 2.3 2.1 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Peptidase_S41 PF03572.13 CCF37732.1 - 4.4e-08 32.7 0.0 2e-07 30.5 0.0 2.0 1 1 0 1 1 1 1 Peptidase family S41 Paf1 PF03985.8 CCF37733.1 - 0.42 9.3 6.1 0.5 9.0 4.2 1.0 1 0 0 1 1 1 0 Paf1 PAPA-1 PF04795.7 CCF37733.1 - 0.86 10.3 11.4 3.3 8.4 7.9 2.0 1 1 0 1 1 1 0 PAPA-1-like conserved region TFIIB PF00382.14 CCF37735.1 - 4.1e-41 138.6 1.0 2.8e-23 81.4 0.0 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 CCF37735.1 - 1e-14 53.5 1.4 1.7e-14 52.8 1.0 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding HTH_Tnp_ISL3 PF13542.1 CCF37735.1 - 0.017 14.2 0.1 0.21 10.7 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 Sigma70_r4_2 PF08281.7 CCF37735.1 - 0.028 13.8 0.0 0.094 12.1 0.0 1.9 1 0 0 1 1 1 0 Sigma-70, region 4 Trp_repressor PF01371.14 CCF37735.1 - 0.044 13.6 0.0 9.3 6.2 0.0 2.5 2 0 0 2 2 2 0 Trp repressor protein Thioredoxin PF00085.15 CCF37736.1 - 1e-14 54.0 0.1 1.4e-14 53.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 CCF37736.1 - 0.0082 16.1 0.0 0.015 15.2 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_8 PF13905.1 CCF37736.1 - 0.013 15.5 0.0 0.019 15.0 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_2 PF13098.1 CCF37736.1 - 0.1 12.8 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_9 PF14595.1 CCF37736.1 - 0.15 11.6 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin DUF605 PF04652.11 CCF37737.1 - 1.6e-92 310.8 23.5 1.8e-92 310.6 16.3 1.0 1 0 0 1 1 1 1 Vta1 like adh_short_C2 PF13561.1 CCF37738.1 - 5.4e-37 127.8 0.1 6.5e-37 127.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF37738.1 - 1.8e-23 83.2 0.1 2.3e-23 82.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF37738.1 - 5.4e-10 39.2 0.1 9.1e-10 38.4 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF37738.1 - 4.6e-07 29.5 0.0 6.4e-07 29.0 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.5 CCF37738.1 - 0.00048 19.3 0.0 0.00071 18.7 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) ADH_zinc_N PF00107.21 CCF37738.1 - 0.02 14.4 0.1 0.056 13.0 0.1 1.9 1 1 0 1 1 1 0 Zinc-binding dehydrogenase NAD_binding_10 PF13460.1 CCF37738.1 - 0.058 13.3 1.4 0.12 12.4 1.1 1.7 1 1 1 2 2 2 0 NADH(P)-binding Eno-Rase_NADH_b PF12242.3 CCF37738.1 - 0.098 12.4 1.6 0.21 11.3 1.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase UQ_con PF00179.21 CCF37739.1 - 1.2e-47 160.8 0.0 1.4e-47 160.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CCF37739.1 - 9.4e-05 22.1 0.0 0.00012 21.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 CCF37739.1 - 0.0034 17.0 0.1 0.0065 16.1 0.0 1.5 1 1 0 1 1 1 1 UEV domain RWD PF05773.17 CCF37739.1 - 0.035 14.0 0.0 0.044 13.6 0.0 1.3 1 0 0 1 1 1 0 RWD domain WD40 PF00400.27 CCF37740.1 - 1.7e-12 46.7 20.9 6.5e-06 25.8 0.9 5.2 4 0 0 4 4 4 3 WD domain, G-beta repeat RWD PF05773.17 CCF37740.1 - 0.0007 19.4 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 RWD domain WD40 PF00400.27 CCF37741.1 - 3.9e-41 137.5 17.7 3.5e-10 39.3 0.1 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat VCBS PF13517.1 CCF37741.1 - 0.06 13.7 0.5 0.43 10.9 0.1 2.7 3 0 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Arm PF00514.18 CCF37742.1 - 2.9e-07 30.0 14.3 0.066 13.0 0.0 7.5 8 0 0 8 8 8 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 CCF37742.1 - 0.00019 21.8 10.3 2.6 8.6 0.0 7.2 6 0 0 6 6 6 2 HEAT-like repeat HEAT PF02985.17 CCF37742.1 - 0.0017 18.3 17.0 3.1 8.1 0.0 7.5 9 0 0 9 9 9 2 HEAT repeat HEAT_2 PF13646.1 CCF37742.1 - 0.0023 18.1 5.5 0.44 10.8 0.0 5.3 6 1 1 7 7 7 2 HEAT repeats TIMELESS PF04821.9 CCF37742.1 - 0.024 13.8 0.0 0.17 11.1 0.0 2.3 2 0 0 2 2 2 0 Timeless protein V-ATPase_H_N PF03224.9 CCF37742.1 - 0.069 12.2 0.0 2.5 7.1 0.0 2.5 2 0 0 2 2 2 0 V-ATPase subunit H zf-C2H2_4 PF13894.1 CCF37743.1 - 6.8e-06 26.0 22.2 0.025 14.8 0.8 5.2 4 1 0 4 4 4 4 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF37743.1 - 0.00021 21.4 22.4 0.016 15.4 0.7 5.1 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CCF37743.1 - 0.011 16.0 0.2 0.011 16.0 0.1 4.2 5 1 0 5 5 5 0 Zinc-finger double domain zf-CHCC PF10276.4 CCF37743.1 - 0.087 12.6 3.8 2.3 8.1 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger domain zf-C2H2_jaz PF12171.3 CCF37743.1 - 7.4 6.8 11.1 0.28 11.3 1.7 3.0 2 1 1 3 3 3 0 Zinc-finger double-stranded RNA-binding DSPc PF00782.15 CCF37744.1 - 0.006 16.1 0.0 0.0088 15.6 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain MIP PF00230.15 CCF37746.1 - 6.3e-41 140.3 13.6 7.7e-41 140.0 9.4 1.0 1 0 0 1 1 1 1 Major intrinsic protein DUF165 PF02592.10 CCF37746.1 - 7.8 6.6 9.7 6.5 6.9 2.4 3.1 2 1 1 3 3 3 0 Uncharacterized ACR, YhhQ family COG1738 Aminotran_3 PF00202.16 CCF37747.1 - 3.2e-06 26.2 0.0 4.5e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Claudin_2 PF13903.1 CCF37748.1 - 0.021 14.5 3.3 0.18 11.4 0.9 2.1 1 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF4231 PF14015.1 CCF37748.1 - 0.24 11.4 1.7 4.7 7.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) YrhK PF14145.1 CCF37748.1 - 0.34 10.6 6.7 0.32 10.6 0.3 3.2 3 0 0 3 3 3 0 YrhK-like protein SdpI PF13630.1 CCF37748.1 - 1.4 8.6 4.6 1.4 8.7 1.7 2.1 2 0 0 2 2 2 0 SdpI/YhfL protein family DUF4395 PF14340.1 CCF37748.1 - 3.9 7.5 8.4 1.2 9.1 0.2 3.1 2 1 0 3 3 3 0 Domain of unknown function (DUF4395) Tyrosinase PF00264.15 CCF37749.1 - 1.2e-48 166.1 0.4 1.6e-48 165.8 0.3 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase Glyco_hydro_47 PF01532.15 CCF37750.1 - 3.7e-20 72.0 0.0 4e-20 71.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 XAP5 PF04921.9 CCF37751.1 - 0.038 13.5 0.1 0.042 13.4 0.0 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator VIT1 PF01988.14 CCF37752.1 - 1.8e-57 194.2 5.6 2.7e-57 193.7 3.9 1.2 1 0 0 1 1 1 1 VIT family Oxysterol_BP PF01237.13 CCF37753.1 - 2.2e-52 177.7 0.0 5.9e-42 143.4 0.0 2.2 2 0 0 2 2 2 2 Oxysterol-binding protein UQ_con PF00179.21 CCF37754.1 - 2.2e-39 134.0 0.0 3.1e-39 133.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.5 CCF37754.1 - 1.7e-06 27.5 0.3 3.4e-06 26.5 0.2 1.5 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.1 CCF37754.1 - 0.00057 19.6 0.0 0.00092 18.9 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 CCF37754.1 - 0.027 14.3 0.0 0.04 13.8 0.0 1.3 1 0 0 1 1 1 0 RWD domain UEV PF05743.8 CCF37754.1 - 0.062 12.9 0.0 0.095 12.3 0.0 1.3 1 0 0 1 1 1 0 UEV domain AAA PF00004.24 CCF37755.1 - 1.4e-15 57.6 0.0 2.7e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF37755.1 - 0.00011 22.2 0.0 0.00022 21.2 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.8 CCF37755.1 - 0.00021 20.3 0.0 0.0003 19.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.1 CCF37755.1 - 0.00039 20.5 0.0 0.00073 19.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 CCF37755.1 - 0.0014 18.6 0.0 0.003 17.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CCF37755.1 - 0.0038 18.0 0.1 0.012 16.4 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_5 PF07728.9 CCF37755.1 - 0.0039 16.9 0.1 0.0067 16.1 0.1 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 CCF37755.1 - 0.0042 16.9 0.1 0.01 15.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CCF37755.1 - 0.0045 16.7 0.3 0.011 15.5 0.2 1.6 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 CCF37755.1 - 0.0049 16.3 0.0 0.0092 15.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Zeta_toxin PF06414.7 CCF37755.1 - 0.0069 15.4 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin RuvB_N PF05496.7 CCF37755.1 - 0.007 15.4 0.1 0.012 14.6 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_3 PF07726.6 CCF37755.1 - 0.011 15.3 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.8 CCF37755.1 - 0.018 13.7 0.0 0.026 13.2 0.0 1.1 1 0 0 1 1 1 0 TIP49 C-terminus NB-ARC PF00931.17 CCF37755.1 - 0.025 13.4 0.0 0.037 12.8 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.1 CCF37755.1 - 0.026 14.8 0.1 0.06 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 CCF37755.1 - 0.039 13.0 0.1 0.071 12.2 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 CCF37755.1 - 0.041 14.0 0.0 0.074 13.2 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.1 CCF37755.1 - 0.043 13.2 0.3 0.11 11.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 CCF37755.1 - 0.047 13.2 0.2 0.094 12.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 CCF37755.1 - 0.084 12.0 0.1 0.14 11.3 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein DUF2075 PF09848.4 CCF37755.1 - 0.085 11.8 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.7 CCF37755.1 - 0.1 12.2 0.1 0.24 11.0 0.1 1.6 1 0 0 1 1 1 0 NACHT domain CPT PF07931.7 CCF37755.1 - 0.13 11.9 0.0 0.32 10.5 0.0 1.6 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein KaiC PF06745.8 CCF37755.1 - 0.17 11.0 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 KaiC Aa_trans PF01490.13 CCF37756.1 - 2.9e-59 200.5 32.6 3.7e-59 200.2 22.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein EST1_DNA_bind PF10373.4 CCF37757.1 - 5.6e-21 74.9 1.9 7.3e-21 74.6 0.0 2.0 2 1 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.4 CCF37757.1 - 2.5e-19 69.5 0.4 2.5e-19 69.5 0.3 1.9 3 0 0 3 3 3 1 Telomerase activating protein Est1 TPR_11 PF13414.1 CCF37757.1 - 0.0027 17.3 0.8 0.0068 16.0 0.0 1.9 2 0 0 2 2 2 1 TPR repeat TPR_12 PF13424.1 CCF37757.1 - 0.31 11.0 2.5 0.3 11.0 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat G10 PF01125.12 CCF37759.1 - 1.7e-61 205.9 3.2 2e-61 205.8 2.2 1.0 1 0 0 1 1 1 1 G10 protein Complex1_LYR_2 PF13233.1 CCF37760.1 - 1.6e-06 28.5 0.1 1.9e-06 28.3 0.1 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.10 CCF37760.1 - 7.4e-06 25.6 0.2 1.5e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 CCF37760.1 - 2.6e-05 24.3 0.4 4.6e-05 23.5 0.3 1.6 1 1 0 1 1 1 1 Complex1_LYR-like KilA-N PF04383.8 CCF37761.1 - 0.059 13.0 0.0 0.15 11.6 0.0 1.7 1 1 0 1 1 1 0 KilA-N domain DUF4611 PF15387.1 CCF37761.1 - 5.6 7.1 15.4 0.59 10.3 5.6 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4611) SUN PF03856.8 CCF37762.1 - 2.6e-83 279.1 13.4 4e-83 278.5 9.3 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) DUF605 PF04652.11 CCF37762.1 - 2.8 7.2 14.4 3.7 6.8 10.0 1.1 1 0 0 1 1 1 0 Vta1 like Peptidase_S8 PF00082.17 CCF37764.1 - 1.3e-24 86.8 0.4 1.9e-24 86.3 0.3 1.3 1 0 0 1 1 1 1 Subtilase family PA PF02225.17 CCF37764.1 - 3.3e-13 49.1 0.0 9e-13 47.7 0.0 1.7 1 0 0 1 1 1 1 PA domain SET PF00856.23 CCF37765.1 - 1.1e-09 38.8 0.0 8.9e-09 35.8 0.0 2.3 1 1 0 1 1 1 1 SET domain Lipid_DES PF08557.5 CCF37765.1 - 0.89 8.8 4.0 0.49 9.6 0.1 2.5 3 0 0 3 3 3 0 Sphingolipid Delta4-desaturase (DES) Pkinase PF00069.20 CCF37766.1 - 0.00037 19.7 0.3 0.0008 18.6 0.2 1.5 1 1 0 1 1 1 1 Protein kinase domain DUF1679 PF07914.6 CCF37766.1 - 0.00046 18.9 0.1 0.00056 18.6 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) APH PF01636.18 CCF37766.1 - 0.0092 15.7 0.0 0.013 15.2 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Acyl_transf_3 PF01757.17 CCF37767.1 - 2.3e-26 92.4 29.4 3.1e-26 92.0 20.4 1.1 1 0 0 1 1 1 1 Acyltransferase family Glyco_tranf_2_3 PF13641.1 CCF37768.1 - 3.7e-26 92.3 0.1 5.3e-26 91.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 CCF37768.1 - 1.3e-18 67.2 0.0 1.8e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 CCF37768.1 - 2.1e-18 66.1 0.0 3.3e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_trans_2_3 PF13632.1 CCF37768.1 - 1.4e-17 64.0 0.7 1.4e-17 64.0 0.5 2.4 2 1 1 3 3 3 1 Glycosyl transferase family group 2 Cellulose_synt PF03552.9 CCF37768.1 - 1.6e-06 26.7 0.6 0.0018 16.6 0.1 2.3 2 1 0 2 2 2 2 Cellulose synthase Glyco_tranf_2_2 PF10111.4 CCF37768.1 - 0.01 14.9 0.0 0.015 14.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 SR-25 PF10500.4 CCF37771.1 - 0.0091 15.4 0.3 0.014 14.8 0.2 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Abhydrolase_3 PF07859.8 CCF37771.1 - 0.011 15.3 0.0 0.021 14.4 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ion_trans_2 PF07885.11 CCF37772.1 - 5.7e-34 115.6 24.5 1.9e-20 72.3 1.6 3.0 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.26 CCF37772.1 - 0.29 10.3 18.5 0.026 13.7 1.4 3.1 2 1 1 3 3 3 0 Ion transport protein NPCC PF08058.6 CCF37772.1 - 0.49 10.2 2.0 2 8.2 0.3 2.2 2 0 0 2 2 2 0 Nuclear pore complex component UDPGT PF00201.13 CCF37773.1 - 7.2e-16 57.8 0.0 8.5e-14 50.9 0.0 2.1 2 0 0 2 2 2 2 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_1_3 PF13528.1 CCF37773.1 - 4.5e-07 29.3 0.0 0.0015 17.8 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 1 Glyco_transf_28 PF03033.15 CCF37773.1 - 1.6e-06 27.8 0.4 3.7e-06 26.7 0.2 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Phageshock_PspD PF09584.5 CCF37773.1 - 0.03 14.0 0.0 0.064 12.9 0.0 1.4 1 0 0 1 1 1 0 Phage shock protein PspD (Phageshock_PspD) Trp_DMAT PF11991.3 CCF37774.1 - 1.5e-76 257.9 0.0 2.4e-76 257.2 0.0 1.3 2 0 0 2 2 2 1 Tryptophan dimethylallyltransferase Sel1 PF08238.7 CCF37775.1 - 2.9e-19 69.0 32.6 4.9e-08 33.3 0.4 7.7 7 0 0 7 7 7 6 Sel1 repeat TPR_1 PF00515.23 CCF37775.1 - 0.00055 19.4 0.4 0.0032 17.0 0.3 2.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.1 CCF37775.1 - 0.011 15.3 0.8 0.011 15.3 0.6 2.7 2 1 0 2 2 2 0 TPR repeat TPR_16 PF13432.1 CCF37775.1 - 0.019 15.6 0.3 0.019 15.6 0.2 3.6 4 1 1 5 5 5 0 Tetratricopeptide repeat zf-C2H2 PF00096.21 CCF37776.1 - 4.1e-23 80.2 24.8 1.5e-05 25.0 0.1 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CCF37776.1 - 1.3e-21 75.7 29.2 3e-07 30.3 0.7 6.3 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.1 CCF37776.1 - 1.1e-15 56.7 23.8 0.00028 21.0 2.6 4.7 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CCF37776.1 - 1.1e-06 28.5 2.7 1.5 9.0 0.0 4.5 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CCF37776.1 - 0.0013 18.8 9.3 2.1 8.6 0.0 4.4 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 CCF37776.1 - 0.0031 17.3 16.2 1.4 8.9 0.8 4.4 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2HC_2 PF13913.1 CCF37776.1 - 0.014 15.0 6.8 1.2 8.9 0.1 3.8 3 0 0 3 3 3 0 zinc-finger of a C2HC-type C1_4 PF07975.7 CCF37776.1 - 0.033 14.1 0.7 1.2 9.2 0.0 2.6 2 1 1 3 3 3 0 TFIIH C1-like domain XPA_N PF01286.13 CCF37776.1 - 0.088 12.4 0.3 0.088 12.4 0.2 3.3 4 0 0 4 4 4 0 XPA protein N-terminal Zn-ribbon_8 PF09723.5 CCF37776.1 - 0.14 12.1 11.4 8.7 6.3 1.4 3.8 2 1 1 3 3 3 0 Zinc ribbon domain C1_1 PF00130.17 CCF37776.1 - 3.3 7.5 7.1 1.1 9.0 1.1 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Prenyltrans PF00432.16 CCF37778.1 - 3.1e-08 33.0 0.3 3.6e-06 26.4 0.0 2.5 2 0 0 2 2 2 2 Prenyltransferase and squalene oxidase repeat Prenyltrans_1 PF13243.1 CCF37778.1 - 1.3e-05 25.1 0.0 0.00068 19.6 0.0 2.2 1 1 1 2 2 2 2 Prenyltransferase-like Prenyltrans_2 PF13249.1 CCF37778.1 - 0.00013 22.3 0.1 0.0081 16.5 0.0 2.2 2 0 0 2 2 2 1 Prenyltransferase-like ABM PF03992.11 CCF37779.1 - 0.002 18.1 0.1 0.021 14.8 0.0 2.0 2 0 0 2 2 2 1 Antibiotic biosynthesis monooxygenase Cu-oxidase_2 PF07731.9 CCF37780.1 - 2.5e-19 69.1 0.2 3.2e-19 68.8 0.2 1.2 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_3 PF07732.10 CCF37780.1 - 0.045 13.4 0.0 0.057 13.1 0.0 1.2 1 0 0 1 1 1 0 Multicopper oxidase MFS_1 PF07690.11 CCF37781.1 - 1.4e-32 112.8 69.4 8.1e-26 90.5 25.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF37781.1 - 1.3e-14 53.6 32.0 7.1e-11 41.3 8.5 2.9 2 1 1 3 3 3 2 Sugar (and other) transporter MFS_2 PF13347.1 CCF37781.1 - 0.0002 19.9 9.4 0.0002 19.9 6.5 2.9 1 1 2 3 3 3 1 MFS/sugar transport protein adh_short PF00106.20 CCF37782.1 - 1.4e-16 60.9 0.0 7e-08 32.5 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.1 CCF37782.1 - 2.3e-06 27.5 0.0 0.0024 17.6 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF37782.1 - 3.8e-05 23.4 0.0 0.21 11.2 0.0 2.1 2 0 0 2 2 2 2 KR domain 2-Hacid_dh_C PF02826.14 CCF37782.1 - 0.018 14.1 0.0 0.029 13.5 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Fungal_trans PF04082.13 CCF37784.1 - 8.6e-12 44.4 1.0 2.3e-11 43.0 0.7 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF37784.1 - 9.2e-08 31.8 8.6 2.1e-07 30.7 5.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cut8_C PF08559.5 CCF37784.1 - 0.026 14.3 0.0 0.093 12.5 0.0 1.9 1 0 0 1 1 1 0 Cut8 six-helix bundle Phosphoesterase PF04185.9 CCF37786.1 - 4.5e-21 75.4 0.9 9.9e-21 74.3 0.6 1.5 1 1 0 1 1 1 1 Phosphoesterase family SUFU_C PF12470.3 CCF37788.1 - 0.18 11.4 0.3 0.26 10.8 0.2 1.3 1 0 0 1 1 1 0 Suppressor of Fused Gli/Ci N terminal binding domain DUF2937 PF11157.3 CCF37788.1 - 3.5 6.9 5.8 0.24 10.7 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) Pkinase PF00069.20 CCF37789.1 - 2.5e-06 26.8 0.0 3.8e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 CCF37789.1 - 0.047 12.7 0.0 0.084 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.12 CCF37789.1 - 0.11 11.5 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase dsrm PF00035.20 CCF37791.1 - 0.00068 20.1 0.0 0.00097 19.6 0.0 1.3 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.1 CCF37791.1 - 0.003 17.8 0.0 0.0078 16.4 0.0 1.7 1 1 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 SKG6 PF08693.5 CCF37793.1 - 4e-07 29.2 0.3 8.4e-07 28.2 0.2 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain RicinB_lectin_2 PF14200.1 CCF37793.1 - 7.5e-07 29.4 1.4 6.6e-06 26.4 0.2 2.4 1 1 1 2 2 2 1 Ricin-type beta-trefoil lectin domain-like DUF4448 PF14610.1 CCF37793.1 - 0.0018 17.8 0.0 0.0029 17.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Rax2 PF12768.2 CCF37793.1 - 0.011 14.9 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity VSP PF03302.8 CCF37793.1 - 0.07 11.7 5.1 0.11 11.1 3.5 1.3 1 0 0 1 1 1 0 Giardia variant-specific surface protein TRI12 PF06609.8 CCF37794.1 - 6.5e-15 54.3 1.9 7.8e-15 54.0 1.3 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.11 CCF37794.1 - 5.5e-07 28.6 19.5 3.5e-05 22.6 13.3 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF4233 PF14017.1 CCF37794.1 - 9.5 6.2 9.6 23 4.9 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF4233) LRR_6 PF13516.1 CCF37796.1 - 0.0027 17.5 8.8 40 4.7 0.0 6.9 7 0 0 7 7 7 0 Leucine Rich repeat LRR_4 PF12799.2 CCF37796.1 - 0.0056 16.2 6.8 0.12 11.9 0.0 4.6 5 1 0 5 5 5 1 Leucine Rich repeats (2 copies) RNase_H2-Ydr279 PF09468.5 CCF37796.1 - 0.21 10.7 9.4 0.46 9.6 6.5 1.6 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Nop14 PF04147.7 CCF37796.1 - 2.5 5.9 21.2 3.8 5.3 14.7 1.2 1 0 0 1 1 1 0 Nop14-like family Hid1 PF12722.2 CCF37796.1 - 4.9 4.7 4.8 0.58 7.7 0.5 1.4 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein FCP1_C PF09309.5 CCF37797.1 - 0.39 9.9 6.5 0.46 9.7 4.5 1.0 1 0 0 1 1 1 0 FCP1, C-terminal Atrophin-1 PF03154.10 CCF37797.1 - 0.97 7.4 8.2 1 7.4 5.7 1.0 1 0 0 1 1 1 0 Atrophin-1 family TFIIF_alpha PF05793.7 CCF37797.1 - 5.8 5.1 18.7 6.5 5.0 13.0 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF755 PF05501.6 CCF37797.1 - 9 6.3 18.8 11 6.0 13.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Aldo_ket_red PF00248.16 CCF37798.1 - 2.8e-54 183.8 0.0 3.3e-54 183.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family ADH_N PF08240.7 CCF37799.1 - 1.9e-27 95.1 0.4 1.9e-27 95.1 0.3 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF37799.1 - 9.8e-16 57.4 0.5 1.7e-15 56.6 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.9 CCF37799.1 - 0.0023 17.3 0.3 0.0062 15.9 0.1 1.8 1 1 1 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain HI0933_like PF03486.9 CCF37799.1 - 0.011 14.2 0.4 0.017 13.6 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein 3HCDH_N PF02737.13 CCF37799.1 - 0.055 13.1 0.8 0.099 12.2 0.6 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 7tm_2 PF00002.19 CCF37800.1 - 0.048 12.7 0.0 0.065 12.3 0.0 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) Abhydrolase_6 PF12697.2 CCF37801.1 - 1.2e-19 71.1 0.8 1.2e-19 71.1 0.5 2.4 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF37801.1 - 1.5e-09 37.7 0.0 2.5e-07 30.5 0.0 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF37801.1 - 5.5e-07 29.3 0.1 1.3e-06 28.1 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.13 CCF37801.1 - 0.093 11.9 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Peptidase_S9 PF00326.16 CCF37801.1 - 0.19 10.9 0.0 0.32 10.1 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family DUF2074 PF09847.4 CCF37802.1 - 5.2 5.7 10.0 5.5 5.6 6.9 1.0 1 0 0 1 1 1 0 Predicted permease (DUF2074) GST_N_2 PF13409.1 CCF37803.1 - 2.7e-05 24.0 0.0 6.2e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 CCF37803.1 - 7.6e-05 22.8 0.0 0.00016 21.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 CCF37803.1 - 0.00039 20.5 0.1 0.0011 19.1 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 CCF37803.1 - 0.0094 15.8 0.0 0.024 14.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 CCF37803.1 - 0.041 14.3 0.0 0.077 13.4 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain BPL_N PF09825.4 CCF37804.1 - 8.8e-40 136.6 0.0 1.2e-39 136.2 0.0 1.2 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.14 CCF37804.1 - 5.8e-19 68.3 0.0 9.9e-19 67.5 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family IBN_N PF03810.14 CCF37807.1 - 1.7e-11 43.8 0.1 1.7e-09 37.4 0.0 3.7 2 1 1 3 3 3 2 Importin-beta N-terminal domain Xpo1 PF08389.7 CCF37807.1 - 0.00019 21.3 0.0 0.0065 16.3 0.0 2.8 2 0 0 2 2 2 1 Exportin 1-like protein RPAP3_C PF13877.1 CCF37807.1 - 0.063 13.2 0.3 0.35 10.8 0.0 2.6 2 0 0 2 2 2 0 Potential Monad-binding region of RPAP3 NDK PF00334.14 CCF37809.1 - 3.8e-52 175.6 0.0 4.6e-52 175.3 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Glyco_hydro_31 PF01055.21 CCF37810.1 - 2.4e-150 501.2 2.6 3.2e-150 500.8 1.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 CCF37810.1 - 3.8e-23 81.1 0.1 1.1e-22 79.6 0.1 1.9 1 0 0 1 1 1 1 Galactose mutarotase-like MS_channel PF00924.13 CCF37811.1 - 2.9e-20 72.5 0.6 4.6e-20 71.8 0.5 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_7 PF13499.1 CCF37811.1 - 0.004 17.2 0.1 0.01 15.9 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 CCF37811.1 - 0.02 14.1 0.2 0.059 12.7 0.1 1.9 1 0 0 1 1 1 0 EF hand ubiquitin PF00240.18 CCF37812.1 - 2e-06 27.0 0.0 3.8e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.1 CCF37812.1 - 0.0077 16.1 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 CCF37812.1 - 0.022 14.9 0.5 0.061 13.5 0.1 1.8 1 1 1 2 2 2 0 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.3 CCF37812.1 - 0.056 13.1 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF4141 PF13605.1 CCF37812.1 - 0.066 12.4 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4141) Adaptin_N PF01602.15 CCF37813.1 - 4.2e-95 319.0 13.1 4.2e-95 319.0 9.1 1.5 2 0 0 2 2 2 1 Adaptin N terminal region Coatamer_beta_C PF07718.7 CCF37813.1 - 4e-63 211.2 0.9 8.6e-63 210.2 0.7 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.1 CCF37813.1 - 4.6e-63 210.7 0.0 1.6e-62 208.9 0.0 2.0 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform HEAT_2 PF13646.1 CCF37813.1 - 6.3e-13 48.8 6.3 4.9e-08 33.1 0.0 3.9 2 1 1 3 3 3 2 HEAT repeats Cnd1 PF12717.2 CCF37813.1 - 0.00012 22.0 10.7 0.0019 18.1 0.1 4.2 2 1 2 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 CCF37813.1 - 0.0008 19.2 0.4 1.1 9.5 0.0 4.2 4 0 0 4 4 4 1 HEAT repeat DUF2603 PF10788.4 CCF37813.1 - 0.012 15.3 2.4 0.054 13.2 1.7 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2603) AP4E_app_platf PF14807.1 CCF37813.1 - 0.026 14.7 0.1 0.12 12.5 0.1 2.2 1 0 0 1 1 1 0 Adaptin AP4 complex epsilon appendage platform HEAT_EZ PF13513.1 CCF37813.1 - 0.055 13.9 4.8 3.8 8.1 0.0 4.8 5 0 0 5 5 5 0 HEAT-like repeat RE_Alw26IDE PF09665.5 CCF37813.1 - 6.2 5.4 10.7 0.64 8.6 0.5 3.2 3 1 1 4 4 4 0 Type II restriction endonuclease (RE_Alw26IDE) Methyltransf_21 PF05050.7 CCF37814.1 - 0.0091 15.9 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain HAND PF09110.6 CCF37814.1 - 0.069 13.5 5.5 0.17 12.2 3.8 1.6 1 0 0 1 1 1 0 HAND RNase_P_p30 PF01876.11 CCF37814.1 - 0.089 12.0 0.1 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 RNase P subunit p30 GST_C_3 PF14497.1 CCF37814.1 - 0.098 13.1 0.1 1.1 9.7 0.0 2.6 1 1 1 2 2 2 0 Glutathione S-transferase, C-terminal domain RIO1 PF01163.17 CCF37815.1 - 5e-43 146.6 0.1 1.4e-30 106.0 0.0 2.1 2 0 0 2 2 2 2 RIO1 family Rio2_N PF09202.6 CCF37815.1 - 1.4e-29 102.0 0.0 3.2e-29 100.8 0.0 1.6 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.18 CCF37815.1 - 7.4e-08 32.4 0.1 0.00051 19.8 0.0 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.9 CCF37815.1 - 9.2e-07 28.1 0.0 0.0014 17.7 0.0 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Nop14 PF04147.7 CCF37815.1 - 3.5 5.4 9.9 4.9 4.9 6.9 1.1 1 0 0 1 1 1 0 Nop14-like family RRM_1 PF00076.17 CCF37816.1 - 1.1e-15 56.9 0.0 5.2e-11 42.0 0.0 2.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF37816.1 - 5.8e-10 39.0 0.0 1.2e-07 31.6 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF37816.1 - 0.023 14.5 0.0 0.62 9.9 0.0 2.6 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Acetyltransf_1 PF00583.19 CCF37817.1 - 9.6e-06 25.5 0.2 2e-05 24.4 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF37817.1 - 0.0019 18.3 0.0 0.0094 16.0 0.0 2.2 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain E1-E2_ATPase PF00122.15 CCF37818.1 - 1.5e-64 217.2 0.8 1.5e-64 217.2 0.5 2.2 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 CCF37818.1 - 1.6e-21 77.7 0.1 3.7e-21 76.5 0.1 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 CCF37818.1 - 3e-11 43.8 0.0 6.6e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 CCF37818.1 - 8.4e-11 41.1 0.0 2.3e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 CCF37818.1 - 0.0019 17.8 0.0 0.0035 16.9 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF37818.1 - 0.055 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Putative hydrolase of sodium-potassium ATPase alpha subunit 4HBT_3 PF13622.1 CCF37819.1 - 1.6e-41 142.7 0.1 1.8e-41 142.5 0.1 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily COX5B PF01215.14 CCF37821.1 - 2.8e-37 127.4 0.0 3.2e-37 127.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb Zn-ribbon_8 PF09723.5 CCF37821.1 - 0.08 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Zinc ribbon domain DUF4604 PF15377.1 CCF37822.1 - 1.1e-09 38.7 12.9 1.2e-09 38.5 8.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) HLH PF00010.21 CCF37823.1 - 9.1e-13 47.7 1.0 1.9e-12 46.7 0.7 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DivIC PF04977.10 CCF37823.1 - 1 8.8 9.0 0.038 13.4 1.1 2.3 2 0 0 2 2 2 0 Septum formation initiator DUF2985 PF11204.3 CCF37824.1 - 5.5e-38 128.5 1.6 5.5e-38 128.5 1.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2985) Acyl_transf_3 PF01757.17 CCF37824.1 - 6 5.6 12.1 2.7 6.7 0.9 2.1 2 0 0 2 2 2 0 Acyltransferase family Nuc_sug_transp PF04142.10 CCF37825.1 - 3.6e-10 39.3 1.2 1.3e-09 37.5 0.8 1.9 1 1 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.15 CCF37825.1 - 6.6e-09 35.8 24.8 1.9e-05 24.7 2.7 3.4 2 1 1 3 3 3 3 EamA-like transporter family TPT PF03151.11 CCF37825.1 - 0.017 14.7 21.7 0.12 12.0 5.9 2.6 3 0 0 3 3 3 0 Triose-phosphate Transporter family DUF4231 PF14015.1 CCF37825.1 - 1.3 9.0 3.4 0.79 9.7 0.2 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF4231) Yippee-Mis18 PF03226.9 CCF37826.1 - 2.1e-17 62.9 0.2 2.2e-17 62.8 0.1 1.0 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF2039 PF10217.4 CCF37826.1 - 0.012 15.5 0.1 0.012 15.5 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) RIG-I_C-RD PF11648.3 CCF37826.1 - 0.069 13.0 0.1 0.081 12.7 0.1 1.2 1 0 0 1 1 1 0 C-terminal domain of RIG-I RRM_1 PF00076.17 CCF37827.1 - 1.2e-16 60.1 0.0 1.9e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF37827.1 - 6.5e-15 54.8 0.0 1e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF37827.1 - 2e-06 27.5 0.0 3.2e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 CCF37827.1 - 0.0081 16.5 14.8 0.0081 16.5 10.2 4.6 3 2 2 5 5 5 1 C-terminal duplication domain of Friend of PRMT1 DUF1932 PF09130.6 CCF37829.1 - 3.3e-22 77.9 0.1 6.3e-22 77.1 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1932) FAD_binding_4 PF01565.18 CCF37832.1 - 6.5e-21 74.2 2.0 1.4e-20 73.2 1.4 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 CCF37832.1 - 1.1e-05 25.2 0.3 2.4e-05 24.1 0.2 1.7 1 0 0 1 1 1 1 Berberine and berberine like SKIP_SNW PF02731.10 CCF37834.1 - 4.3e-67 224.4 4.7 4.3e-67 224.4 3.2 2.6 3 0 0 3 3 3 1 SKIP/SNW domain DUF4603 PF15376.1 CCF37834.1 - 0.18 8.9 18.5 0.25 8.5 12.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) FAM60A PF15396.1 CCF37834.1 - 0.6 9.8 8.3 1.5 8.5 5.7 1.8 1 0 0 1 1 1 0 Protein Family FAM60A PBP1_TM PF14812.1 CCF37835.1 - 2 8.7 11.4 0.58 10.4 4.6 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Frag1 PF10277.4 CCF37836.1 - 4.2e-25 88.5 5.2 5e-25 88.2 3.6 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Pkinase PF00069.20 CCF37837.1 - 3e-65 219.9 0.0 3.6e-65 219.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF37837.1 - 1e-35 123.0 0.0 1.4e-35 122.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF37837.1 - 0.00048 19.1 0.0 0.0015 17.5 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Sec10 PF07393.6 CCF37838.1 - 6.9e-79 265.8 0.0 8.2e-79 265.6 0.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 ApbA PF02558.11 CCF37840.1 - 2.6e-33 114.6 0.0 3.5e-33 114.1 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.6 CCF37840.1 - 1.6e-27 95.9 0.0 2.6e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal DUF3292 PF11696.3 CCF37843.1 - 4.3e-163 543.5 0.0 5.5e-163 543.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3292) Pex24p PF06398.6 CCF37843.1 - 0.033 13.0 0.0 0.051 12.3 0.0 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin PRT_C PF08372.5 CCF37843.1 - 0.14 11.6 0.1 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal Abhydrolase_6 PF12697.2 CCF37844.1 - 1.1e-30 107.2 1.4 1.2e-30 107.0 0.9 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF37844.1 - 5.6e-12 45.6 0.0 9.5e-12 44.8 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF37844.1 - 0.00032 20.3 0.2 0.15 11.6 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Thioesterase PF00975.15 CCF37844.1 - 0.0012 19.1 0.1 0.0023 18.1 0.0 1.5 2 0 0 2 2 2 1 Thioesterase domain Abhydrolase_8 PF06259.7 CCF37844.1 - 0.0097 15.4 0.0 0.02 14.4 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase Fungal_trans PF04082.13 CCF37845.1 - 2.1e-12 46.4 0.0 3.2e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF37845.1 - 0.0029 17.4 10.5 0.0063 16.3 7.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SR-25 PF10500.4 CCF37845.1 - 9.9 5.5 14.5 0.91 8.9 2.9 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein adh_short PF00106.20 CCF37846.1 - 8.3e-08 32.3 0.0 3.7e-06 26.9 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase HCO3_cotransp PF00955.16 CCF37847.1 - 2.4e-54 184.8 13.8 1.1e-30 106.8 0.2 2.1 1 1 1 2 2 2 2 HCO3- transporter family BPL_LplA_LipB PF03099.14 CCF37848.1 - 1.8e-07 31.2 0.0 2.7e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Peptidase_C65 PF10275.4 CCF37849.1 - 1.4e-34 119.5 0.0 1.8e-34 119.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase C65 Otubain PAT1 PF09770.4 CCF37849.1 - 5.1 5.2 15.6 6 4.9 10.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ABC_tran PF00005.22 CCF37850.1 - 9.2e-38 129.6 0.0 3.8e-18 66.1 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 CCF37850.1 - 1.3e-31 110.0 17.1 1.1e-18 67.6 0.4 2.7 2 1 0 2 2 2 2 ABC transporter transmembrane region AAA_23 PF13476.1 CCF37850.1 - 2.4e-08 34.5 0.4 0.00014 22.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 CCF37850.1 - 3.6e-08 33.0 0.1 0.003 17.0 0.0 2.9 3 0 0 3 3 3 2 AAA domain SMC_N PF02463.14 CCF37850.1 - 3.8e-08 32.8 1.9 0.0063 15.7 0.0 3.3 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF37850.1 - 1.5e-07 31.7 0.1 0.14 12.0 0.0 3.3 2 1 1 3 3 3 2 AAA domain AAA_29 PF13555.1 CCF37850.1 - 2.9e-07 29.8 1.8 0.0075 15.7 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain Miro PF08477.8 CCF37850.1 - 3.4e-05 24.3 0.1 0.5 10.8 0.0 2.6 2 0 0 2 2 2 2 Miro-like protein FtsK_SpoIIIE PF01580.13 CCF37850.1 - 4.2e-05 23.1 0.1 0.029 13.8 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family T2SE PF00437.15 CCF37850.1 - 7e-05 21.8 0.6 0.058 12.2 0.1 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_19 PF13245.1 CCF37850.1 - 0.00012 21.7 0.5 0.05 13.3 0.1 3.4 2 0 0 2 2 2 1 Part of AAA domain DUF258 PF03193.11 CCF37850.1 - 0.00012 21.2 0.1 0.38 9.9 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 CCF37850.1 - 0.00013 22.0 0.5 0.27 11.2 0.1 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_17 PF13207.1 CCF37850.1 - 0.00016 22.4 1.4 0.24 12.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 CCF37850.1 - 0.0003 20.5 0.5 0.086 12.5 0.1 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 CCF37850.1 - 0.00042 19.8 0.7 0.4 10.0 0.0 2.3 2 0 0 2 2 2 2 AAA-like domain AAA_22 PF13401.1 CCF37850.1 - 0.00049 20.2 0.9 1.3 9.2 0.3 2.9 2 1 0 2 2 2 2 AAA domain NACHT PF05729.7 CCF37850.1 - 0.0013 18.3 0.2 2.1 7.9 0.0 2.5 2 0 0 2 2 2 2 NACHT domain Viral_helicase1 PF01443.13 CCF37850.1 - 0.0015 18.0 0.1 0.51 9.8 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase MMR_HSR1 PF01926.18 CCF37850.1 - 0.0022 17.9 0.4 0.11 12.4 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_33 PF13671.1 CCF37850.1 - 0.0025 17.6 0.2 4 7.3 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.1 CCF37850.1 - 0.0025 18.0 0.2 2.6 8.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.12 CCF37850.1 - 0.0028 17.5 0.1 0.0028 17.5 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function DUF87 Pox_A32 PF04665.7 CCF37850.1 - 0.0039 16.5 2.2 0.41 9.8 0.1 2.3 2 0 0 2 2 2 1 Poxvirus A32 protein cobW PF02492.14 CCF37850.1 - 0.004 16.6 2.4 0.96 8.8 0.7 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.17 CCF37850.1 - 0.0083 15.0 1.2 2.6 6.7 0.0 3.0 2 1 0 2 2 2 1 NB-ARC domain Dynamin_N PF00350.18 CCF37850.1 - 0.0087 15.8 1.7 2.3 8.0 0.2 2.4 2 0 0 2 2 2 1 Dynamin family AAA_14 PF13173.1 CCF37850.1 - 0.027 14.3 0.0 4 7.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.20 CCF37850.1 - 0.028 13.8 0.1 4.5 6.7 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_28 PF13521.1 CCF37850.1 - 0.029 14.3 1.2 2 8.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 CCF37850.1 - 0.037 13.5 0.7 3 7.3 0.1 2.7 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 CCF37850.1 - 0.039 13.6 1.7 6.5 6.4 0.0 2.4 2 0 0 2 2 2 0 NTPase Septin PF00735.13 CCF37850.1 - 0.072 12.1 0.1 10 5.0 0.0 2.2 2 0 0 2 2 2 0 Septin SbcCD_C PF13558.1 CCF37850.1 - 0.078 12.8 0.0 0.23 11.3 0.0 1.8 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DEAD PF00270.24 CCF37850.1 - 0.11 11.9 0.0 18 4.8 0.0 2.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase PduV-EutP PF10662.4 CCF37850.1 - 0.13 11.7 0.3 11 5.5 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF2075 PF09848.4 CCF37850.1 - 0.15 11.0 0.3 1.3 7.8 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_15 PF13175.1 CCF37850.1 - 0.19 10.7 0.0 0.93 8.4 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain Arch_ATPase PF01637.13 CCF37850.1 - 0.2 11.3 0.0 4 7.0 0.0 2.3 2 0 0 2 2 2 0 Archaeal ATPase TrwB_AAD_bind PF10412.4 CCF37850.1 - 0.42 9.1 3.3 8.6 4.8 0.0 3.1 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain ATP_bind_1 PF03029.12 CCF37850.1 - 0.55 9.7 2.4 5.9 6.3 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DAP3 PF10236.4 CCF37850.1 - 0.85 8.4 1.7 8.6 5.1 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 Profilin PF00235.14 CCF37851.1 - 1e-36 125.6 1.8 1.2e-36 125.5 1.3 1.0 1 0 0 1 1 1 1 Profilin Got1 PF04178.7 CCF37852.1 - 1.8e-18 66.7 11.4 2e-18 66.5 7.9 1.0 1 0 0 1 1 1 1 Got1/Sft2-like family YrhK PF14145.1 CCF37852.1 - 0.46 10.1 9.7 0.1 12.2 2.5 2.4 2 0 0 2 2 2 0 YrhK-like protein DUF4418 PF14387.1 CCF37852.1 - 0.47 10.2 2.5 2.4 7.9 1.8 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4418) YL1_C PF08265.6 CCF37853.1 - 5.1e-16 57.9 0.1 7.9e-16 57.3 0.1 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain tRNA-synt_1d PF00750.14 CCF37854.1 - 2.8e-51 174.3 0.2 5.3e-51 173.5 0.1 1.4 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 CCF37854.1 - 3.4e-14 52.8 0.0 7.8e-14 51.6 0.0 1.7 1 0 0 1 1 1 1 DALR anticodon binding domain Homeobox PF00046.24 CCF37857.1 - 5e-20 70.8 4.5 1e-19 69.8 3.2 1.6 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 CCF37857.1 - 0.00024 20.7 0.5 0.00069 19.2 0.4 1.8 1 0 0 1 1 1 1 Homeobox KN domain SAD_SRA PF02182.12 CCF37859.1 - 1.4e-27 95.9 0.0 2.3e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 SAD/SRA domain Orn_Arg_deC_N PF02784.11 CCF37860.1 - 4.1e-79 265.3 0.0 9.9e-79 264.0 0.0 1.6 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.17 CCF37860.1 - 7.9e-32 109.4 0.1 1.4e-31 108.5 0.1 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Bul1_C PF04426.7 CCF37861.1 - 0.00029 20.1 0.0 0.00039 19.7 0.0 1.2 1 0 0 1 1 1 1 Bul1 C terminus FAD_binding_4 PF01565.18 CCF37862.1 - 3.7e-20 71.8 5.6 6e-20 71.1 3.8 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 CCF37862.1 - 2.6e-07 30.4 0.0 5.5e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like Bac_surface_Ag PF01103.18 CCF37863.1 - 1.1e-36 126.9 0.3 1.5e-36 126.5 0.2 1.2 1 0 0 1 1 1 1 Surface antigen TB2_DP1_HVA22 PF03134.14 CCF37864.1 - 1.5e-26 91.9 5.9 2e-26 91.5 4.1 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF4407 PF14362.1 CCF37864.1 - 0.15 10.9 0.3 8 5.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) RFX_DNA_binding PF02257.10 CCF37865.1 - 5.3e-29 100.1 0.1 1.4e-28 98.8 0.1 1.7 1 0 0 1 1 1 1 RFX DNA-binding domain FMN_dh PF01070.13 CCF37866.1 - 7e-88 294.8 0.4 3.1e-48 164.4 0.0 2.1 1 1 1 2 2 2 2 FMN-dependent dehydrogenase IMPDH PF00478.20 CCF37866.1 - 0.002 17.0 0.1 0.0051 15.7 0.1 1.6 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.12 CCF37866.1 - 0.006 15.5 0.0 0.0094 14.8 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase Peptidase_M19 PF01244.16 CCF37866.1 - 0.0086 15.0 0.1 0.023 13.6 0.0 1.8 2 0 0 2 2 2 1 Membrane dipeptidase (Peptidase family M19) His_biosynth PF00977.16 CCF37866.1 - 0.022 14.0 0.4 0.26 10.5 0.3 2.5 1 1 0 1 1 1 0 Histidine biosynthesis protein Ino80_Iec3 PF14612.1 CCF37867.1 - 2.2e-31 109.7 6.3 4.1e-29 102.2 0.5 2.4 2 1 1 3 3 3 2 IEC3 subunit of the Ino80 complex, chromatin re-modelling Iso_dh PF00180.15 CCF37868.1 - 4.4e-73 246.2 0.0 5.2e-73 245.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase AAA PF00004.24 CCF37869.1 - 6.9e-15 55.4 0.0 1.7e-14 54.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 CCF37869.1 - 0.00014 21.5 0.1 0.0003 20.4 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain TFIIF_alpha PF05793.7 CCF37869.1 - 0.00036 19.0 32.5 0.00036 19.0 22.5 2.6 3 0 0 3 3 3 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) MIP-T3 PF10243.4 CCF37869.1 - 0.0011 17.6 30.1 0.0011 17.6 20.9 1.8 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 AAA_22 PF13401.1 CCF37869.1 - 0.0025 17.9 1.4 0.11 12.6 0.1 2.7 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.9 CCF37869.1 - 0.0075 16.0 0.0 0.025 14.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 CCF37869.1 - 0.014 16.2 0.0 0.061 14.1 0.0 2.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CCF37869.1 - 0.017 15.0 0.9 0.075 13.0 0.1 2.3 2 1 0 2 2 2 0 AAA ATPase domain ArgK PF03308.11 CCF37869.1 - 0.059 12.1 0.0 0.12 11.1 0.0 1.4 1 0 0 1 1 1 0 ArgK protein Mem_trans PF03547.13 CCF37869.1 - 0.53 8.5 0.5 0.63 8.2 0.3 1.3 1 0 0 1 1 1 0 Membrane transport protein Mg_chelatase PF01078.16 CCF37869.1 - 0.63 9.1 2.8 0.48 9.5 0.2 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI FAD_binding_4 PF01565.18 CCF37870.1 - 1.8e-21 76.0 3.8 3.5e-21 75.1 1.9 2.0 1 1 1 2 2 2 1 FAD binding domain BBE PF08031.7 CCF37870.1 - 1.3e-07 31.3 0.3 3e-07 30.2 0.2 1.6 1 0 0 1 1 1 1 Berberine and berberine like MFS_1 PF07690.11 CCF37872.1 - 5.9e-35 120.6 59.1 1.3e-24 86.5 22.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Glyco_hydro_92 PF07971.7 CCF37873.1 - 5.4e-159 530.0 0.6 6.9e-159 529.6 0.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 MFS_1 PF07690.11 CCF37874.1 - 1e-17 63.9 13.7 1.6e-17 63.2 9.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF37874.1 - 0.082 12.7 1.5 1.5 8.6 0.1 3.0 3 0 0 3 3 3 0 MFS_1 like family NAD_binding_2 PF03446.10 CCF37875.1 - 3.8e-22 78.8 0.2 5.7e-22 78.2 0.2 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 CCF37875.1 - 4.1e-09 36.5 0.1 1.2e-08 35.0 0.0 1.8 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Peptidase_S8 PF00082.17 CCF37876.1 - 6.6e-16 58.2 0.1 1.3e-15 57.2 0.0 1.5 2 0 0 2 2 2 1 Subtilase family Inhibitor_I9 PF05922.11 CCF37876.1 - 9.9e-12 45.2 0.0 2e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 RAP1 PF07218.6 CCF37877.1 - 0.0073 14.4 1.0 0.01 13.9 0.7 1.1 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) SR-25 PF10500.4 CCF37877.1 - 0.15 11.5 8.7 0.28 10.6 6.1 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Fungal_trans PF04082.13 CCF37878.1 - 2e-11 43.2 0.0 2.9e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF37878.1 - 3.2e-08 33.3 7.5 4.9e-08 32.7 5.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pkinase PF00069.20 CCF37879.1 - 1e-20 73.9 0.0 5.4e-20 71.6 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF37879.1 - 6.1e-08 32.0 0.1 0.005 15.9 0.0 3.3 3 1 0 3 3 3 2 Protein tyrosine kinase p450 PF00067.17 CCF37880.1 - 0.0047 15.4 0.0 0.0057 15.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_23 PF13489.1 CCF37882.1 - 9.6e-15 54.6 0.0 1.6e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF37882.1 - 1.9e-05 25.0 0.0 9.5e-05 22.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF37882.1 - 0.00011 22.6 0.0 0.011 16.2 0.0 2.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF37882.1 - 0.0011 19.5 0.0 0.0041 17.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF37882.1 - 0.0012 18.4 0.0 0.024 14.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain UPF0029 PF01205.14 CCF37883.1 - 2.8e-23 81.7 0.0 7.4e-23 80.3 0.0 1.7 2 0 0 2 2 2 1 Uncharacterized protein family UPF0029 TrkH PF02386.11 CCF37884.1 - 4.9e-118 393.7 17.6 2.1e-116 388.3 6.8 2.1 2 0 0 2 2 2 2 Cation transport protein HCO3_cotransp PF00955.16 CCF37885.1 - 4.7e-70 236.6 12.2 2.8e-41 141.7 3.2 2.0 1 1 1 2 2 2 2 HCO3- transporter family Zn_clus PF00172.13 CCF37886.1 - 4.7e-07 29.6 7.5 6.7e-07 29.1 5.2 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_transf_90 PF05686.7 CCF37887.1 - 1.8e-19 69.6 0.0 1.3e-15 56.9 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 90 Fungal_trans PF04082.13 CCF37889.1 - 2.2e-13 49.7 0.0 4.7e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Type_III_YscG PF09477.5 CCF37889.1 - 0.017 15.1 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial type II secretion system chaperone protein (type_III_yscG) Pol_alpha_B_N PF08418.5 CCF37889.1 - 1.5 8.3 6.4 2.7 7.4 4.4 1.5 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Ribosomal_60s PF00428.14 CCF37890.1 - 9.2e-17 61.2 3.7 1.1e-16 60.9 2.6 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein MutS_V PF00488.16 CCF37891.1 - 9e-79 264.1 0.0 1.5e-78 263.4 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 CCF37891.1 - 9.3e-38 130.0 6.0 1.5e-37 129.3 4.2 1.3 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.15 CCF37891.1 - 3e-18 65.9 0.0 6.5e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.12 CCF37891.1 - 9.9e-07 28.9 0.0 2.3e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.13 CCF37891.1 - 4.3e-05 23.6 0.0 7.7e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 MutS family domain IV AAA_29 PF13555.1 CCF37891.1 - 0.025 14.0 0.0 0.063 12.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.1 CCF37891.1 - 0.41 10.9 0.0 0.81 9.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain PsbW PF07123.7 CCF37892.1 - 9.9 6.2 7.9 3.2 7.8 0.4 2.3 1 1 1 2 2 2 0 Photosystem II reaction centre W protein (PsbW) Glyco_hydro_38 PF01074.17 CCF37893.1 - 2e-92 309.3 1.1 3.3e-92 308.6 0.8 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.8 CCF37893.1 - 4.9e-71 239.8 0.0 9.1e-71 239.0 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.6 CCF37893.1 - 8.5e-27 93.1 0.0 1.7e-26 92.2 0.0 1.5 1 0 0 1 1 1 1 Alpha mannosidase, middle domain Pkinase PF00069.20 CCF37894.1 - 2.6e-22 79.2 0.0 3.2e-22 78.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF37894.1 - 2.4e-07 30.1 0.0 3.1e-06 26.4 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CCF37894.1 - 0.041 13.6 0.0 0.12 12.0 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Aldedh PF00171.17 CCF37895.1 - 8.5e-84 281.5 0.0 1e-83 281.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 CCF37895.1 - 0.029 13.0 0.0 0.04 12.6 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) Methyltransf_13 PF08421.6 CCF37898.1 - 0.018 14.4 0.1 0.024 14.1 0.1 1.2 1 0 0 1 1 1 0 Putative zinc binding domain DEAD PF00270.24 CCF37899.1 - 5.4e-18 65.0 0.0 7.4e-18 64.6 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 CCF37899.1 - 0.0016 18.2 0.0 0.0035 17.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF4636 PF15468.1 CCF37899.1 - 0.074 12.5 0.8 0.13 11.7 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) NACHT PF05729.7 CCF37900.1 - 2.5e-12 46.7 0.0 4.2e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 CCF37900.1 - 1e-08 35.4 0.1 3.2e-08 33.7 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain PNP_UDP_1 PF01048.15 CCF37900.1 - 1.7e-08 33.7 0.3 5.2e-08 32.1 0.2 1.7 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_22 PF13401.1 CCF37900.1 - 7.5e-06 26.1 0.0 2.5e-05 24.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.17 CCF37900.1 - 4.7e-05 22.3 0.0 7.6e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain ABC_tran PF00005.22 CCF37900.1 - 0.05 13.8 0.0 0.65 10.2 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_14 PF13173.1 CCF37900.1 - 0.057 13.3 0.0 0.39 10.6 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_35 PF14516.1 CCF37900.1 - 0.07 11.7 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain RNA_helicase PF00910.17 CCF37900.1 - 0.13 12.4 0.0 0.39 10.9 0.0 1.9 1 0 0 1 1 1 0 RNA helicase KAP_NTPase PF07693.9 CCF37900.1 - 0.13 11.2 0.3 2.4 7.0 0.1 2.0 1 1 1 2 2 2 0 KAP family P-loop domain TCTP PF00838.12 CCF37901.1 - 6.9e-64 214.7 1.0 7.8e-64 214.6 0.7 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein PRMT5 PF05185.11 CCF37901.1 - 0.076 11.9 0.0 0.082 11.8 0.0 1.0 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Ribosomal_L14 PF00238.14 CCF37903.1 - 4.8e-32 110.2 0.0 5.4e-32 110.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e MFS_1 PF07690.11 CCF37904.1 - 8.7e-23 80.5 20.4 8.7e-23 80.5 14.2 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF37904.1 - 1.4e-14 53.3 4.8 4.5e-08 31.9 0.0 2.6 2 1 0 2 2 2 2 MFS/sugar transport protein Sugar_tr PF00083.19 CCF37904.1 - 5.9e-08 31.7 4.9 9e-08 31.1 3.4 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 CCF37904.1 - 0.0021 16.3 2.9 0.0023 16.1 1.4 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) ATG22 PF11700.3 CCF37904.1 - 0.0029 16.1 0.0 0.0029 16.1 0.0 3.4 2 2 1 3 3 3 2 Vacuole effluxer Atg22 like MFS_1_like PF12832.2 CCF37904.1 - 0.0058 16.3 0.2 0.0058 16.3 0.1 3.3 3 1 1 4 4 4 1 MFS_1 like family Tom22 PF04281.8 CCF37904.1 - 0.035 13.6 0.0 0.32 10.5 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 OATP PF03137.15 CCF37904.1 - 0.084 10.9 1.5 3.1 5.7 1.0 2.2 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Nuc_H_symport PF03825.11 CCF37904.1 - 0.21 10.3 9.7 0.77 8.4 6.7 1.8 1 1 0 1 1 1 0 Nucleoside H+ symporter adh_short PF00106.20 CCF37905.1 - 2.4e-27 95.8 0.0 4.3e-27 95.0 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF37905.1 - 1e-19 71.2 0.0 1.2e-19 70.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF37905.1 - 8e-10 38.6 0.0 1.2e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF37905.1 - 2.4e-06 27.6 0.1 7.6e-06 26.0 0.0 1.9 2 1 0 2 2 2 1 NADH(P)-binding DUF1776 PF08643.5 CCF37905.1 - 9.5e-06 24.9 0.0 1.5e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) ADH_zinc_N PF00107.21 CCF37905.1 - 0.00045 19.7 0.0 0.0039 16.7 0.0 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Epimerase PF01370.16 CCF37905.1 - 0.0064 15.9 0.1 0.018 14.5 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.14 CCF37905.1 - 0.016 14.3 0.0 0.046 12.8 0.0 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.12 CCF37905.1 - 0.018 13.9 0.0 0.03 13.2 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain NmrA PF05368.8 CCF37905.1 - 0.021 14.0 0.0 0.042 13.0 0.0 1.5 1 0 0 1 1 1 0 NmrA-like family TrkA_N PF02254.13 CCF37905.1 - 0.094 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Ecm29 PF13001.2 CCF37908.1 - 4.4e-71 239.8 0.0 8.1e-71 239.0 0.0 1.5 1 0 0 1 1 1 1 Proteasome stabiliser HEAT PF02985.17 CCF37908.1 - 3.4e-06 26.6 4.1 2.8 8.2 0.0 7.1 8 0 0 8 8 8 2 HEAT repeat Vac14_Fab1_bd PF12755.2 CCF37908.1 - 0.13 12.6 0.0 0.49 10.8 0.0 2.0 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region V4R PF02830.13 CCF37908.1 - 0.14 11.9 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 V4R domain HEAT_EZ PF13513.1 CCF37908.1 - 0.67 10.5 13.0 0.97 10.0 0.1 6.4 6 1 1 7 7 7 0 HEAT-like repeat MFS_1 PF07690.11 CCF37910.1 - 6.9e-23 80.9 22.5 6.9e-23 80.9 15.6 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF37910.1 - 0.00017 20.3 37.1 0.0047 15.5 25.8 2.9 1 1 0 1 1 1 1 Sugar (and other) transporter Lyase_1 PF00206.15 CCF37911.1 - 3.8e-26 92.0 0.3 6.2e-26 91.3 0.2 1.3 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.1 CCF37911.1 - 4.7e-09 36.2 0.1 1.8e-08 34.3 0.0 2.1 2 0 0 2 2 2 1 Argininosuccinate lyase C-terminal Abhydrolase_5 PF12695.2 CCF37912.1 - 9.4e-06 25.4 0.4 1.5e-05 24.8 0.3 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 CCF37912.1 - 6.8e-05 22.5 0.2 0.00016 21.3 0.1 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF37912.1 - 8.6e-05 22.5 1.2 0.00016 21.5 0.8 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.20 CCF37912.1 - 0.0017 17.9 0.0 0.0038 16.8 0.0 1.7 1 1 0 1 1 1 1 Lipase (class 3) Esterase PF00756.15 CCF37912.1 - 0.0039 16.6 0.1 0.0066 15.8 0.1 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_1 PF00561.15 CCF37912.1 - 0.0056 16.2 0.0 0.33 10.4 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF915 PF06028.6 CCF37912.1 - 0.0097 15.0 0.0 0.014 14.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Thioesterase PF00975.15 CCF37912.1 - 0.11 12.7 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Thioesterase domain Exo_endo_phos PF03372.18 CCF37913.1 - 1.3e-05 25.2 0.3 4e-05 23.6 0.3 1.7 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family NB-ARC PF00931.17 CCF37913.1 - 0.0046 15.8 0.0 0.0076 15.1 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain FANCI_HD1 PF14679.1 CCF37915.1 - 0.024 14.3 0.1 0.028 14.1 0.1 1.2 1 0 0 1 1 1 0 FANCI helical domain 1 Sec7 PF01369.15 CCF37916.1 - 7.6e-67 224.6 7.8 2.1e-66 223.2 0.5 3.4 3 1 0 3 3 3 1 Sec7 domain DUF1981 PF09324.5 CCF37916.1 - 1.3e-31 107.9 0.3 1.3e-31 107.9 0.2 3.8 4 0 0 4 4 4 1 Domain of unknown function (DUF1981) Methyltransf_11 PF08241.7 CCF37917.1 - 8.6e-15 55.0 0.0 1.5e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF37917.1 - 3e-12 46.3 0.0 3.6e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF37917.1 - 4.5e-12 45.9 0.0 7.3e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF37917.1 - 5.3e-11 42.7 0.0 4.5e-10 39.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF37917.1 - 1.4e-09 38.0 0.0 2.6e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF37917.1 - 3.4e-09 37.2 0.0 9e-09 35.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF37917.1 - 6.7e-08 32.9 0.0 3.2e-07 30.7 0.0 2.1 3 0 0 3 3 3 1 Methyltransferase domain CMAS PF02353.15 CCF37917.1 - 9.3e-06 24.9 0.0 1.1e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.9 CCF37917.1 - 0.0013 18.0 0.0 0.0023 17.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Pox_MCEL PF03291.11 CCF37917.1 - 0.042 12.7 0.0 0.14 10.9 0.0 1.7 1 1 1 2 2 2 0 mRNA capping enzyme FmrO PF07091.6 CCF37917.1 - 0.056 12.4 0.0 0.082 11.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) UPF0146 PF03686.8 CCF37917.1 - 0.11 12.2 0.0 0.39 10.5 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0146) Bac_rhodopsin PF01036.13 CCF37918.1 - 3.8e-34 117.9 20.3 5e-34 117.5 14.1 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein SDA1 PF05285.7 CCF37920.1 - 1.5 8.0 11.6 0.095 11.9 4.3 1.8 2 0 0 2 2 2 0 SDA1 Nop14 PF04147.7 CCF37920.1 - 2.9 5.7 13.9 5.5 4.7 9.6 1.3 1 0 0 1 1 1 0 Nop14-like family Complex1_LYR_1 PF13232.1 CCF37921.1 - 3.9e-18 65.4 3.0 5.2e-18 65.0 2.1 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.10 CCF37921.1 - 3.5e-17 61.9 2.4 4.9e-17 61.4 1.6 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.1 CCF37921.1 - 0.1 13.0 0.4 0.13 12.7 0.3 1.2 1 0 0 1 1 1 0 Complex1_LYR-like DUF1823 PF08853.6 CCF37921.1 - 0.15 11.8 0.2 0.24 11.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1823) KR PF08659.5 CCF37923.1 - 8.2e-54 182.0 0.3 5e-52 176.2 0.1 3.0 3 0 0 3 3 3 1 KR domain adh_short PF00106.20 CCF37923.1 - 2.2e-47 161.0 0.2 9.9e-46 155.7 0.0 2.5 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_12 PF08242.7 CCF37923.1 - 2e-17 63.4 0.0 7.6e-17 61.6 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF37923.1 - 2.3e-17 63.2 0.0 5.2e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Condensation PF00668.15 CCF37923.1 - 2.7e-13 49.4 0.0 4.9e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Condensation domain Methyltransf_11 PF08241.7 CCF37923.1 - 8.4e-13 48.6 0.0 3.8e-12 46.5 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF37923.1 - 7.2e-12 45.1 0.0 1.8e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF37923.1 - 4.2e-09 36.9 0.0 3.2e-08 34.1 0.0 2.6 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF37923.1 - 3.7e-06 27.2 0.1 1.8e-05 24.9 0.0 2.4 3 0 0 3 3 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF37923.1 - 8.7e-06 25.0 0.0 2.3e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PP-binding PF00550.20 CCF37923.1 - 1.7e-05 25.0 0.2 5.1e-05 23.4 0.1 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_16 PF10294.4 CCF37923.1 - 0.00033 20.1 0.0 0.00064 19.2 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase N2227 PF07942.7 CCF37923.1 - 0.0084 15.0 0.3 0.11 11.4 0.0 2.3 2 0 0 2 2 2 1 N2227-like protein PCMT PF01135.14 CCF37923.1 - 0.031 13.8 0.0 0.073 12.5 0.0 1.6 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_26 PF13659.1 CCF37923.1 - 0.04 13.9 0.0 0.17 11.9 0.0 2.1 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.7 CCF37923.1 - 0.045 12.6 0.0 0.1 11.4 0.0 1.5 1 0 0 1 1 1 0 DREV methyltransferase DPPIV_N PF00930.16 CCF37924.1 - 1.3e-108 362.7 0.1 1.9e-108 362.2 0.1 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.16 CCF37924.1 - 3.1e-37 127.8 0.1 5e-37 127.1 0.1 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CCF37924.1 - 9.9e-08 31.8 0.0 2.1e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF37924.1 - 3.1e-06 27.2 0.1 1.2e-05 25.2 0.1 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 CCF37924.1 - 0.073 12.6 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold RNA_pol_Rpb6 PF01192.17 CCF37926.1 - 1.3e-24 85.7 0.3 2e-24 85.1 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 zf-C2H2 PF00096.21 CCF37927.1 - 3.7e-27 92.9 49.3 0.00017 21.7 0.3 10.4 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF37927.1 - 7.5e-23 79.1 53.3 0.00054 20.1 0.3 10.3 10 0 0 10 10 10 8 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CCF37927.1 - 9.8e-15 54.0 47.7 0.00012 22.1 1.1 10.9 11 0 0 11 11 11 4 Zinc-finger double domain zf-C2H2_jaz PF12171.3 CCF37927.1 - 3.5e-06 26.9 25.0 2.1 8.5 0.1 9.1 11 0 0 11 11 11 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CCF37927.1 - 3.3e-05 23.9 19.3 0.042 14.0 0.0 7.7 9 0 0 9 9 9 2 Zinc-finger of C2H2 type DUF4187 PF13821.1 CCF37927.1 - 0.0018 17.7 1.9 0.0036 16.8 0.1 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4187) CHORD PF04968.7 CCF37927.1 - 7.7 6.8 24.9 18 5.6 0.9 6.6 6 2 1 7 7 7 0 CHORD Zip PF02535.17 CCF37928.1 - 1.4e-10 40.6 1.6 1.4e-10 40.6 1.1 2.0 1 1 1 2 2 2 2 ZIP Zinc transporter DUF2834 PF11196.3 CCF37928.1 - 0.77 9.9 3.6 1 9.5 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2834) Inhibitor_I9 PF05922.11 CCF37929.1 - 8.1e-22 77.5 0.5 1.5e-21 76.7 0.4 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 Peptidase_S8 PF00082.17 CCF37929.1 - 5.1e-17 61.9 0.5 5.1e-17 61.9 0.4 1.6 2 0 0 2 2 2 1 Subtilase family Aldo_ket_red PF00248.16 CCF37930.1 - 2.8e-72 242.9 0.0 3.5e-72 242.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family TFIIA PF03153.8 CCF37932.1 - 1.2e-77 262.4 2.3 1.6e-77 261.9 1.6 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit WD40 PF00400.27 CCF37933.1 - 3.1e-25 87.0 17.3 1.7e-06 27.6 0.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.6 CCF37933.1 - 1.3e-06 28.2 0.3 0.0002 21.1 0.1 2.5 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Apc4_WD40 PF12894.2 CCF37933.1 - 0.025 14.0 0.0 0.55 9.7 0.0 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Kelch_4 PF13418.1 CCF37934.1 - 2.7e-24 84.6 9.0 2.1e-08 33.7 0.0 5.5 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.1 CCF37934.1 - 4.4e-21 74.1 3.6 6.7e-05 22.8 0.0 5.3 3 1 2 5 5 5 4 Kelch motif Kelch_5 PF13854.1 CCF37934.1 - 7.1e-21 73.7 6.8 8.5e-07 28.8 0.0 5.0 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.20 CCF37934.1 - 3.4e-19 68.1 0.6 0.00014 21.3 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.1 CCF37934.1 - 2e-18 65.9 7.8 1.3e-06 28.4 0.0 5.7 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.10 CCF37934.1 - 7.9e-16 57.1 4.3 0.0016 18.1 0.0 4.7 4 0 0 4 4 4 4 Kelch motif BTB PF00651.26 CCF37934.1 - 1.6e-09 37.6 0.0 2.9e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 CCF37934.1 - 0.054 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 BTB And C-terminal Kelch Rax2 PF12768.2 CCF37934.1 - 0.23 10.6 0.0 0.74 8.9 0.0 1.8 1 1 1 2 2 2 0 Cortical protein marker for cell polarity peroxidase PF00141.18 CCF37935.1 - 3e-09 36.6 0.8 5.9e-09 35.7 0.5 1.4 1 1 0 1 1 1 1 Peroxidase FA_desaturase PF00487.19 CCF37936.1 - 0.038 13.4 0.7 0.055 12.9 0.5 1.2 1 0 0 1 1 1 0 Fatty acid desaturase Med3 PF11593.3 CCF37938.1 - 3.2 6.8 6.1 3.2 6.8 4.2 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Mucin PF01456.12 CCF37938.1 - 4.7 6.9 17.1 6.6 6.5 11.9 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Ribosomal_L16 PF00252.13 CCF37939.1 - 9.8e-29 99.7 0.0 1.4e-28 99.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Ribosomal_L7Ae PF01248.21 CCF37940.1 - 9e-23 79.6 0.0 1e-22 79.4 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family TBP PF00352.16 CCF37941.1 - 3e-32 109.8 0.0 5.2e-31 105.8 0.0 2.0 1 1 1 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 CCF37941.1 - 0.00043 20.2 0.0 0.00065 19.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3378) Terpene_synth_C PF03936.11 CCF37943.1 - 1.4e-22 80.2 0.2 2e-22 79.7 0.1 1.1 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain YhzD PF14120.1 CCF37945.1 - 0.013 15.3 0.7 0.027 14.3 0.5 1.5 1 0 0 1 1 1 0 YhzD-like protein Tyrosinase PF00264.15 CCF37946.1 - 2.3e-34 119.5 5.5 3.2e-34 119.0 3.8 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase HET PF06985.6 CCF37948.1 - 3e-17 63.0 0.0 5.4e-17 62.2 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Myb_DNA-binding PF00249.26 CCF37949.1 - 2.5e-14 53.0 2.3 3.9e-07 30.0 0.5 2.7 2 1 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CCF37949.1 - 6.8e-13 48.5 0.6 9e-06 25.7 0.1 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.6 CCF37949.1 - 0.034 13.9 0.3 0.11 12.3 0.0 1.9 1 1 1 2 2 2 0 Rap1 Myb domain HTH_38 PF13936.1 CCF37949.1 - 0.042 13.4 0.0 0.088 12.3 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain MADF_DNA_bdg PF10545.4 CCF37949.1 - 0.051 13.7 1.9 10 6.4 0.1 2.8 1 1 1 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like PLA2_B PF01735.13 CCF37950.1 - 1.1e-192 640.6 0.0 1.3e-192 640.4 0.0 1.0 1 0 0 1 1 1 1 Lysophospholipase catalytic domain BAF1_ABF1 PF04684.8 CCF37951.1 - 0.09 11.6 12.3 0.14 10.9 8.5 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CDK2AP PF09806.4 CCF37951.1 - 0.71 10.0 14.1 1.6 8.9 9.7 1.6 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Macoilin PF09726.4 CCF37951.1 - 9.4 4.3 13.5 13 3.9 9.4 1.1 1 0 0 1 1 1 0 Transmembrane protein ACBP PF00887.14 CCF37952.1 - 2.8e-15 55.7 0.1 3.1e-15 55.5 0.1 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein Ribonuclease_3 PF00636.21 CCF37953.1 - 2.5e-12 47.2 0.0 7.2e-12 45.7 0.0 1.8 2 0 0 2 2 2 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 CCF37953.1 - 8.2e-08 32.2 0.0 2.2e-07 30.8 0.0 1.7 2 0 0 2 2 2 1 Ribonuclease-III-like dsrm PF00035.20 CCF37953.1 - 0.00071 20.1 0.0 0.0015 19.0 0.0 1.7 1 0 0 1 1 1 1 Double-stranded RNA binding motif MRP-S33 PF08293.6 CCF37954.1 - 3.9e-28 97.2 0.0 4.8e-28 96.9 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 PUF PF00806.14 CCF37955.1 - 4.9e-39 129.6 0.8 2e-06 26.9 0.0 8.8 9 0 0 9 9 9 7 Pumilio-family RNA binding repeat Pribosyl_synth PF14572.1 CCF37957.1 - 3.9e-42 144.0 1.7 1.5e-36 125.8 0.3 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.1 CCF37957.1 - 8.3e-31 106.1 0.0 2.7e-30 104.4 0.0 1.9 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 CCF37957.1 - 1.2e-14 54.1 0.1 2.7e-14 52.9 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 CCF37957.1 - 0.00066 18.9 0.1 0.0012 18.1 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Beta-lactamase PF00144.19 CCF37958.1 - 6.9e-32 110.7 0.0 1e-31 110.2 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase eIF-3_zeta PF05091.7 CCF37960.1 - 0.031 12.9 0.6 0.036 12.6 0.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) BRF1 PF07741.8 CCF37960.1 - 0.074 13.2 1.1 0.088 13.0 0.8 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain DUF2968 PF11180.3 CCF37960.1 - 0.48 9.7 10.6 0.59 9.4 7.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) DDE_1 PF03184.14 CCF37961.1 - 2.3e-25 89.0 0.0 2.7e-25 88.8 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease CCDC14 PF15254.1 CCF37962.1 - 0.019 13.3 0.0 0.02 13.3 0.0 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 Casein PF00363.13 CCF37962.1 - 0.096 13.3 0.1 0.13 12.9 0.1 1.1 1 0 0 1 1 1 0 Casein DLH PF01738.13 CCF37964.1 - 1.6e-18 66.7 0.0 2.1e-18 66.4 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 CCF37964.1 - 1.4e-06 28.1 0.0 1.9e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF37964.1 - 0.00016 21.6 2.1 0.018 14.8 0.7 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family adh_short PF00106.20 CCF37965.1 - 4.2e-27 95.0 0.2 5.3e-27 94.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF37965.1 - 5e-15 55.9 0.3 6.2e-15 55.6 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF37965.1 - 3.5e-10 39.8 0.1 6.3e-10 38.9 0.1 1.3 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF37965.1 - 4.7e-05 23.4 0.3 0.00077 19.5 0.2 2.2 1 1 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 CCF37965.1 - 9.3e-05 21.4 0.3 0.00019 20.4 0.2 1.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.16 CCF37965.1 - 0.00016 21.1 0.2 0.01 15.2 0.0 2.2 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.12 CCF37965.1 - 0.0011 19.3 0.3 0.0031 17.8 0.1 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 CCF37965.1 - 0.0034 17.4 0.2 0.0075 16.3 0.2 1.8 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Eno-Rase_NADH_b PF12242.3 CCF37965.1 - 0.0035 17.1 0.2 0.0082 15.9 0.1 1.6 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase AlaDh_PNT_C PF01262.16 CCF37965.1 - 0.036 13.6 0.1 0.2 11.2 0.0 2.1 2 1 1 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain Glyco_tran_WecB PF03808.8 CCF37965.1 - 0.047 13.0 0.0 0.077 12.4 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family DJ-1_PfpI PF01965.19 CCF37966.1 - 5.2e-25 87.6 0.0 8.8e-25 86.8 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family DJ-1_PfpI_N PF13587.1 CCF37966.1 - 1.4e-12 46.8 0.0 3.1e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of DJ-1_PfpI family GATase PF00117.23 CCF37966.1 - 0.065 12.6 0.0 0.083 12.3 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferase class-I GATase_3 PF07685.9 CCF37966.1 - 0.096 12.2 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Sensor PF13796.1 CCF37968.1 - 0.02 14.4 0.4 0.036 13.6 0.3 1.4 1 0 0 1 1 1 0 Putative sensor BatA PF07584.6 CCF37968.1 - 0.084 13.0 0.4 0.084 13.0 0.3 2.1 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal Amino_oxidase PF01593.19 CCF37969.1 - 1.3e-37 129.9 0.2 1.2e-21 77.3 0.0 2.4 2 1 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 CCF37969.1 - 2.1e-13 50.1 0.0 4.3e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 CCF37969.1 - 3.7e-06 26.8 0.1 0.074 12.8 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox PF00070.22 CCF37969.1 - 1.4e-05 25.3 0.2 3.1e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF37969.1 - 5.5e-05 23.3 0.1 0.00049 20.2 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CCF37969.1 - 5.8e-05 23.0 0.0 0.0011 18.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF37969.1 - 8.2e-05 21.6 0.1 0.00014 20.8 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 CCF37969.1 - 0.00013 20.5 0.2 0.0029 16.1 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.19 CCF37969.1 - 0.0002 20.3 0.0 0.00078 18.4 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 CCF37969.1 - 0.0013 17.8 0.9 0.002 17.2 0.6 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 CCF37969.1 - 0.0051 15.9 0.0 0.0085 15.2 0.0 1.3 1 0 0 1 1 1 1 Thi4 family 3HCDH_N PF02737.13 CCF37969.1 - 0.032 13.8 0.2 0.06 12.9 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.2 CCF37969.1 - 0.04 13.0 0.0 0.18 10.8 0.0 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 CCF37969.1 - 0.12 11.2 0.3 0.18 10.6 0.2 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein HpcH_HpaI PF03328.9 CCF37970.1 - 2.4e-34 118.1 0.0 3.1e-34 117.7 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PEP-utilizers_C PF02896.13 CCF37970.1 - 5e-05 22.3 0.3 0.00088 18.2 0.2 2.6 2 1 0 2 2 2 1 PEP-utilising enzyme, TIM barrel domain 2-Hacid_dh_C PF02826.14 CCF37971.1 - 1.7e-48 164.1 0.0 2.3e-48 163.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 CCF37971.1 - 9.3e-23 80.1 0.0 1.1e-22 79.9 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AdoHcyase_NAD PF00670.16 CCF37971.1 - 5.6e-05 23.0 0.0 9.5e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_2 PF03446.10 CCF37971.1 - 0.0031 17.3 0.0 0.006 16.4 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.7 CCF37971.1 - 0.013 14.8 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain MFS_1 PF07690.11 CCF37973.1 - 2.5e-36 125.1 50.1 2.5e-36 125.1 34.7 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF37973.1 - 5.2e-11 41.7 13.1 5.2e-11 41.7 9.0 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.15 CCF37973.1 - 0.026 12.5 3.1 0.052 11.6 2.1 1.4 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family HNH_2 PF13391.1 CCF37974.1 - 1.5e-07 31.0 0.0 2.8e-07 30.2 0.0 1.4 1 1 0 1 1 1 1 HNH endonuclease Zn_clus PF00172.13 CCF37975.1 - 2.1e-07 30.7 9.9 3.2e-07 30.1 6.9 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF37975.1 - 0.014 13.9 0.0 0.023 13.2 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain Fungal_trans PF04082.13 CCF37976.1 - 7.7e-64 215.0 0.0 1.1e-63 214.5 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Hep_59 PF07052.6 CCF37978.1 - 9.2e-15 54.8 0.0 1.5e-13 50.9 0.0 3.0 3 1 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 HrpA_pilin PF09589.5 CCF37978.1 - 0.0046 17.3 0.0 0.018 15.4 0.0 2.1 1 1 0 1 1 1 1 HrpA pilus formation protein DUF2870 PF11069.3 CCF37978.1 - 0.079 13.0 0.4 0.32 11.0 0.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2870) Acylphosphatase PF00708.13 CCF37979.1 - 1.9e-24 85.5 0.1 2e-24 85.5 0.0 1.0 1 0 0 1 1 1 1 Acylphosphatase Ank_2 PF12796.2 CCF37980.1 - 5.3e-54 180.5 2.4 1.6e-15 57.1 0.0 9.5 4 2 5 9 9 9 9 Ankyrin repeats (3 copies) Ank PF00023.25 CCF37980.1 - 3.6e-43 143.2 12.9 2.1e-06 27.2 0.0 12.9 14 0 0 14 14 14 9 Ankyrin repeat Ank_3 PF13606.1 CCF37980.1 - 8.5e-37 121.5 5.6 0.0029 17.7 0.0 13.6 16 0 0 16 16 16 9 Ankyrin repeat Ank_4 PF13637.1 CCF37980.1 - 1.3e-35 121.1 2.3 7.8e-06 26.2 0.0 11.2 9 3 3 12 12 12 6 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF37980.1 - 2.1e-34 116.7 7.8 0.0016 18.6 0.0 11.9 12 0 0 12 12 12 8 Ankyrin repeats (many copies) adh_short_C2 PF13561.1 CCF37981.1 - 2.1e-35 122.6 2.8 2.7e-35 122.2 1.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF37981.1 - 2.9e-33 115.1 5.4 4.3e-33 114.5 3.7 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF37981.1 - 2.5e-15 56.6 3.4 3.7e-15 56.0 2.3 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF37981.1 - 0.00097 18.6 3.5 0.0026 17.2 2.4 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Ketoacyl-synt_C PF02801.17 CCF37981.1 - 0.031 14.1 0.2 0.07 12.9 0.1 1.6 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain 3HCDH_N PF02737.13 CCF37981.1 - 0.046 13.3 1.9 0.079 12.6 1.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.14 CCF37981.1 - 0.12 11.4 3.0 0.1 11.6 0.9 1.8 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain COesterase PF00135.23 CCF37982.1 - 3e-92 310.0 1.5 4.1e-84 283.2 0.4 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF37982.1 - 2.1e-15 56.8 0.1 3.4e-15 56.1 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF37982.1 - 0.012 15.3 0.4 0.021 14.5 0.3 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family Cupin_1 PF00190.17 CCF37984.1 - 3.4e-08 33.0 0.0 5e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.6 CCF37984.1 - 0.016 14.6 0.1 0.033 13.6 0.0 1.6 1 1 0 1 1 1 0 Cupin domain MFS_1 PF07690.11 CCF37985.1 - 7.3e-37 126.8 28.4 7.3e-37 126.8 19.7 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily V_ATPase_I PF01496.14 CCF37985.1 - 0.0039 15.1 0.1 0.0094 13.8 0.0 1.5 2 0 0 2 2 2 1 V-type ATPase 116kDa subunit family HpcH_HpaI PF03328.9 CCF37986.1 - 3.7e-26 91.3 0.0 6.6e-26 90.5 0.0 1.4 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family Lambda_tail_I PF06805.7 CCF37986.1 - 0.059 13.2 0.0 9.9 6.0 0.0 2.6 2 0 0 2 2 2 0 Bacteriophage lambda tail assembly protein I Metallophos_3 PF14582.1 CCF37986.1 - 0.13 11.4 0.0 0.52 9.4 0.0 1.8 1 1 1 2 2 2 0 Metallophosphoesterase, calcineurin superfamily WD40 PF00400.27 CCF37987.1 - 8.7e-20 69.8 5.1 2.5e-06 27.1 0.0 6.6 6 1 0 6 6 6 5 WD domain, G-beta repeat Peptidase_S28 PF05577.7 CCF37988.1 - 5.4e-45 153.7 0.2 1.4e-44 152.3 0.1 1.6 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_5 PF12695.2 CCF37988.1 - 0.002 17.8 0.0 0.0078 15.9 0.0 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Gla PF00594.15 CCF37988.1 - 0.013 15.1 1.4 0.061 13.0 0.7 2.2 2 0 0 2 2 2 0 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain DUF2920 PF11144.3 CCF37988.1 - 0.18 10.7 0.0 0.26 10.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Sugar_tr PF00083.19 CCF37990.1 - 8.9e-14 50.8 11.1 9.9e-14 50.7 7.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF37990.1 - 0.00014 20.7 5.6 0.00015 20.5 3.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily ER_lumen_recept PF00810.13 CCF37990.1 - 0.029 14.8 1.6 0.14 12.6 0.7 2.0 1 1 1 2 2 2 0 ER lumen protein retaining receptor Sugar_tr PF00083.19 CCF37991.1 - 2.6e-104 349.3 22.6 3.1e-104 349.0 15.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF37991.1 - 2.1e-24 85.9 32.2 5.2e-21 74.7 18.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF37991.1 - 1e-06 27.2 10.2 2.8e-06 25.8 3.1 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Pirin PF02678.11 CCF37993.1 - 3.7e-32 110.3 0.0 9.4e-32 109.0 0.0 1.7 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.8 CCF37993.1 - 5.2e-26 90.7 0.0 8.7e-25 86.8 0.0 2.2 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.6 CCF37993.1 - 2.1e-06 27.1 2.9 0.00032 20.1 0.5 2.5 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.7 CCF37993.1 - 0.052 12.9 0.5 1.3 8.4 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF861) Sec6 PF06046.8 CCF37994.1 - 1.1e-159 532.2 8.7 1.6e-159 531.6 6.1 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec6 DUF755 PF05501.6 CCF37994.1 - 0.18 11.8 0.5 0.35 10.9 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) OmdA PF13376.1 CCF37994.1 - 0.35 10.5 3.0 0.57 9.8 0.0 2.9 3 0 0 3 3 3 0 Bacteriocin-protection, YdeI or OmpD-Associated DASH_Dam1 PF08653.5 CCF37994.1 - 1.1 9.0 4.0 4.7 7.0 0.2 3.7 4 0 0 4 4 4 0 DASH complex subunit Dam1 CAP59_mtransfer PF11735.3 CCF37995.1 - 3.7e-62 209.7 0.0 4.8e-62 209.3 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 ABC_tran PF00005.22 CCF37996.1 - 1.4e-43 148.4 6.0 9.1e-22 77.8 0.0 3.7 3 1 0 3 3 2 2 ABC transporter AAA_21 PF13304.1 CCF37996.1 - 4.6e-15 56.3 3.3 0.00012 22.1 0.0 4.2 4 0 0 4 4 4 4 AAA domain AAA_29 PF13555.1 CCF37996.1 - 3.6e-10 39.2 0.4 2.6e-05 23.6 0.0 3.4 3 0 0 3 3 3 2 P-loop containing region of AAA domain SMC_N PF02463.14 CCF37996.1 - 6.6e-09 35.3 2.4 0.04 13.1 0.0 4.3 4 1 0 5 5 5 2 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 CCF37996.1 - 1.9e-08 35.1 0.3 0.0024 18.6 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_22 PF13401.1 CCF37996.1 - 1.4e-07 31.7 0.3 0.041 14.0 0.0 3.7 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.18 CCF37996.1 - 7.5e-07 29.1 0.4 0.037 13.9 0.0 2.9 3 0 0 3 3 2 2 50S ribosome-binding GTPase ABC_tran_2 PF12848.2 CCF37996.1 - 1.2e-06 28.2 2.4 3.9e-06 26.6 1.6 1.9 1 0 0 1 1 1 1 ABC transporter Miro PF08477.8 CCF37996.1 - 1.2e-06 29.0 0.1 0.088 13.3 0.0 2.6 2 0 0 2 2 2 2 Miro-like protein DUF258 PF03193.11 CCF37996.1 - 2.3e-06 26.8 0.2 0.031 13.4 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 NACHT PF05729.7 CCF37996.1 - 1.6e-05 24.6 0.1 0.013 15.1 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.1 CCF37996.1 - 3.4e-05 23.5 0.0 0.53 9.8 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_10 PF12846.2 CCF37996.1 - 4e-05 23.2 0.8 0.29 10.5 0.0 2.9 3 0 0 3 3 3 2 AAA-like domain AAA_18 PF13238.1 CCF37996.1 - 4.3e-05 23.8 2.2 0.13 12.6 0.0 3.4 4 0 0 4 4 2 2 AAA domain MobB PF03205.9 CCF37996.1 - 4.6e-05 23.1 0.2 0.19 11.4 0.0 2.5 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 CCF37996.1 - 7.3e-05 22.8 7.9 0.054 13.4 0.1 3.1 2 2 0 2 2 2 2 AAA ATPase domain AAA_28 PF13521.1 CCF37996.1 - 7.9e-05 22.6 0.4 0.059 13.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 CCF37996.1 - 9.6e-05 21.2 1.1 0.022 13.5 0.2 2.4 2 0 0 2 2 2 1 ArgK protein AAA_33 PF13671.1 CCF37996.1 - 0.00015 21.6 1.9 0.47 10.3 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_23 PF13476.1 CCF37996.1 - 0.00018 21.9 11.1 0.02 15.2 0.0 4.0 4 0 0 4 4 4 2 AAA domain DUF87 PF01935.12 CCF37996.1 - 0.00031 20.6 11.4 0.014 15.1 0.2 3.3 4 0 0 4 4 4 2 Domain of unknown function DUF87 Thymidylate_kin PF02223.12 CCF37996.1 - 0.00085 18.7 0.1 0.32 10.3 0.0 2.7 2 0 0 2 2 2 1 Thymidylate kinase AAA PF00004.24 CCF37996.1 - 0.0011 19.2 0.1 0.53 10.4 0.0 2.9 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 CCF37996.1 - 0.0019 18.1 0.0 2.5 7.9 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.1 CCF37996.1 - 0.0024 17.3 0.0 0.12 11.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 CCF37996.1 - 0.0029 17.3 0.0 0.28 10.8 0.0 2.5 2 0 0 2 2 2 1 Archaeal ATPase NTPase_1 PF03266.10 CCF37996.1 - 0.0032 17.1 0.4 2.1 8.0 0.0 2.7 2 0 0 2 2 2 1 NTPase DUF815 PF05673.8 CCF37996.1 - 0.0047 15.8 0.9 1.7 7.5 0.0 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF815) RNA_helicase PF00910.17 CCF37996.1 - 0.0051 16.9 0.1 1.2 9.3 0.0 2.5 2 0 0 2 2 2 1 RNA helicase Dynamin_N PF00350.18 CCF37996.1 - 0.0057 16.4 6.6 0.4 10.4 0.0 3.2 4 0 0 4 4 2 2 Dynamin family Arf PF00025.16 CCF37996.1 - 0.0059 15.8 0.6 0.11 11.6 0.1 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family FtsK_SpoIIIE PF01580.13 CCF37996.1 - 0.0081 15.6 1.2 0.4 10.1 0.0 2.7 3 0 0 3 3 2 1 FtsK/SpoIIIE family AAA_15 PF13175.1 CCF37996.1 - 0.0099 14.9 3.8 0.033 13.2 0.0 3.1 5 0 0 5 5 4 1 AAA ATPase domain ATP-synt_ab PF00006.20 CCF37996.1 - 0.021 14.3 0.0 2.9 7.3 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain cobW PF02492.14 CCF37996.1 - 0.025 14.0 0.9 5.2 6.4 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain G-alpha PF00503.15 CCF37996.1 - 0.03 13.0 0.1 0.03 13.0 0.1 2.7 3 0 0 3 3 3 0 G-protein alpha subunit UPF0079 PF02367.12 CCF37996.1 - 0.035 13.7 0.3 3.7 7.2 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 T2SE PF00437.15 CCF37996.1 - 0.039 12.8 1.2 5 5.9 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein PduV-EutP PF10662.4 CCF37996.1 - 0.043 13.2 0.9 0.81 9.1 0.0 2.6 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.9 CCF37996.1 - 0.044 13.5 0.3 1.7 8.3 0.0 3.1 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) ATP_bind_1 PF03029.12 CCF37996.1 - 0.052 13.0 0.1 17 4.8 0.1 2.9 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Viral_helicase1 PF01443.13 CCF37996.1 - 0.088 12.3 0.1 17 4.8 0.0 2.9 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_13 PF13166.1 CCF37996.1 - 0.19 10.1 8.7 0.93 7.8 0.0 3.5 4 0 0 4 4 4 0 AAA domain NB-ARC PF00931.17 CCF37996.1 - 2.8 6.6 8.6 2.3 7.0 0.0 3.5 4 0 0 4 4 4 0 NB-ARC domain SET PF00856.23 CCF37997.1 - 7.8e-12 45.7 0.0 1.1e-10 42.0 0.0 2.3 1 1 0 1 1 1 1 SET domain SAF PF08666.7 CCF37997.1 - 0.025 14.9 0.1 8.4 6.8 0.0 2.7 3 0 0 3 3 3 0 SAF domain TPR_16 PF13432.1 CCF37997.1 - 3 8.6 10.9 6.4 7.5 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.20 CCF37999.1 - 2.5e-62 210.4 0.0 3.1e-62 210.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF37999.1 - 1.4e-40 138.9 0.0 1.9e-40 138.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF37999.1 - 1.9e-08 33.6 0.0 3.7e-08 32.6 0.0 1.5 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 CCF37999.1 - 0.0048 16.6 0.0 0.021 14.5 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family DSHCT PF08148.7 CCF37999.1 - 0.025 13.8 0.0 0.048 12.9 0.0 1.5 1 0 0 1 1 1 0 DSHCT (NUC185) domain Kdo PF06293.9 CCF37999.1 - 0.044 12.8 0.0 0.078 12.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 CCF37999.1 - 0.059 12.1 0.0 0.082 11.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 DUF500 PF04366.7 CCF38000.1 - 1.7e-44 150.2 1.1 3.6e-44 149.2 0.3 1.9 2 0 0 2 2 2 1 Family of unknown function (DUF500) SH3_1 PF00018.23 CCF38000.1 - 7.3e-14 50.8 0.2 1.9e-13 49.5 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.12 CCF38000.1 - 4.4e-12 45.2 0.0 1.2e-11 43.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 CCF38000.1 - 2.3e-11 43.0 0.0 4.5e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Glyco_hydro_18 PF00704.23 CCF38001.1 - 6e-43 147.5 1.6 7.5e-42 144.0 1.1 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.14 CCF38001.1 - 2.6e-07 30.4 20.8 2.6e-07 30.4 14.4 2.2 2 0 0 2 2 2 1 Chitin recognition protein HTH_psq PF05225.11 CCF38002.1 - 1.4e-13 50.1 0.0 2.3e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.1 CCF38002.1 - 0.0084 15.7 0.0 0.022 14.3 0.0 1.7 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 CCF38002.1 - 0.03 14.3 0.0 0.059 13.3 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_Tc5 PF03221.11 CCF38002.1 - 0.13 12.0 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain DDHD PF02862.12 CCF38003.1 - 1.9e-09 37.6 0.0 3.1e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 DDHD domain Abhydrolase_6 PF12697.2 CCF38003.1 - 0.00047 20.1 0.0 0.0014 18.5 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF38003.1 - 0.006 16.3 0.0 0.013 15.2 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF38003.1 - 0.066 12.7 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF3954 PF13128.1 CCF38008.1 - 0.13 11.7 0.1 0.18 11.2 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3954) COG5 PF10392.4 CCF38009.1 - 0.025 14.5 1.3 0.064 13.2 0.9 1.6 1 0 0 1 1 1 0 Golgi transport complex subunit 5 DUF2450 PF10475.4 CCF38009.1 - 0.056 12.3 0.9 0.094 11.5 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) DUF2561 PF10812.3 CCF38011.1 - 0.093 12.3 1.0 0.24 11.0 0.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2561) zf-DHHC PF01529.15 CCF38011.1 - 3.5 7.0 6.5 0.8 9.0 1.8 1.8 2 0 0 2 2 2 0 DHHC palmitoyltransferase Methyltransf_2 PF00891.13 CCF38012.1 - 2.5e-27 95.6 0.0 4.1e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase THF_DHG_CYH PF00763.18 CCF38013.1 - 6.5e-20 71.3 0.0 9.6e-20 70.7 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.14 CCF38013.1 - 2e-14 53.0 0.0 7.3e-09 34.9 0.0 2.6 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain SBP_bac_5 PF00496.17 CCF38013.1 - 0.065 12.0 0.0 0.09 11.5 0.0 1.1 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 5 Middle DNA_pol3_a_NII PF11490.3 CCF38014.1 - 0.22 11.1 2.7 0.46 10.1 1.9 1.5 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II Apq12 PF12716.2 CCF38015.1 - 2.6e-08 33.3 12.5 4.5e-08 32.6 8.7 1.4 1 0 0 1 1 1 1 Nuclear pore assembly and biogenesis ATP_bind_1 PF03029.12 CCF38016.1 - 9e-71 238.1 0.0 1.1e-70 237.8 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_17 PF13207.1 CCF38016.1 - 6.1e-06 27.0 0.0 1.3e-05 25.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 CCF38016.1 - 0.00093 19.0 0.0 0.0021 17.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 CCF38016.1 - 0.0029 17.7 0.0 0.0073 16.4 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_22 PF13401.1 CCF38016.1 - 0.0039 17.3 0.0 0.0067 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain MobB PF03205.9 CCF38016.1 - 0.004 16.8 0.0 0.0076 15.9 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 CCF38016.1 - 0.0045 16.8 0.0 0.0074 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 CCF38016.1 - 0.011 15.1 0.0 0.04 13.3 0.0 1.8 1 1 1 2 2 2 0 AAA-like domain GTP_EFTU PF00009.22 CCF38016.1 - 0.016 14.6 0.0 4.7 6.5 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.1 CCF38016.1 - 0.017 14.7 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 CCF38016.1 - 0.018 14.5 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain KAP_NTPase PF07693.9 CCF38016.1 - 0.027 13.4 0.0 0.038 12.9 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain AAA_31 PF13614.1 CCF38016.1 - 0.029 14.3 0.2 0.13 12.2 0.0 2.1 2 1 0 2 2 1 0 AAA domain PPV_E1_C PF00519.12 CCF38016.1 - 0.043 12.4 0.0 0.067 11.7 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase MMR_HSR1 PF01926.18 CCF38016.1 - 0.052 13.5 0.0 0.11 12.4 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase cobW PF02492.14 CCF38016.1 - 0.054 12.9 0.1 5 6.5 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.1 CCF38016.1 - 0.055 13.4 0.0 0.15 12.0 0.0 1.7 2 0 0 2 2 1 0 AAA ATPase domain SRP54 PF00448.17 CCF38016.1 - 0.064 12.7 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ABC_tran PF00005.22 CCF38016.1 - 0.066 13.5 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_25 PF13481.1 CCF38016.1 - 0.079 12.3 0.0 0.22 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 CCF38016.1 - 0.081 12.4 0.0 1.3 8.5 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Septin PF00735.13 CCF38016.1 - 0.096 11.6 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Septin NACHT PF05729.7 CCF38016.1 - 0.1 12.2 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_19 PF13245.1 CCF38016.1 - 0.1 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain IstB_IS21 PF01695.12 CCF38016.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.1 CCF38016.1 - 0.14 12.4 0.0 0.41 10.9 0.0 1.9 3 0 0 3 3 1 0 AAA domain Miro PF08477.8 CCF38016.1 - 0.14 12.6 0.0 2.3 8.7 0.0 2.5 3 0 0 3 3 2 0 Miro-like protein Ribosomal_L5_C PF00673.16 CCF38017.1 - 3e-23 81.3 0.0 4.3e-23 80.8 0.0 1.2 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 CCF38017.1 - 8.8e-21 73.4 0.0 2.4e-20 72.0 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L5 ATP-synt_ab PF00006.20 CCF38018.1 - 1.6e-69 233.6 0.0 2.3e-69 233.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 CCF38018.1 - 3.2e-27 95.2 0.1 1.1e-26 93.5 0.1 2.0 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 CCF38018.1 - 1.2e-15 57.4 2.8 3.3e-15 56.0 2.0 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 CCF38018.1 - 0.0039 17.0 0.8 0.015 15.2 0.4 2.2 2 0 0 2 2 2 1 HAS barrel domain Sugar_tr PF00083.19 CCF38019.1 - 9.9e-67 225.4 29.7 1.1e-66 225.2 20.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF38019.1 - 3.8e-17 62.0 36.8 1.1e-15 57.2 20.1 2.9 2 1 1 3 3 3 2 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF38019.1 - 1.9e-05 24.3 9.6 0.00014 21.5 0.9 3.8 3 1 0 3 3 3 2 MFS_1 like family MFS_2 PF13347.1 CCF38019.1 - 0.021 13.2 32.1 0.034 12.5 3.7 3.9 3 1 1 4 4 4 0 MFS/sugar transport protein adh_short PF00106.20 CCF38020.1 - 2.1e-23 83.0 0.7 9.4e-23 80.9 0.5 1.9 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF38020.1 - 4.1e-08 33.1 1.0 2.4e-06 27.3 0.7 2.3 1 1 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF38020.1 - 1.4e-05 25.0 0.0 1.8e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 CCF38020.1 - 0.0045 16.4 0.0 0.0084 15.5 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 CCF38020.1 - 0.0064 15.4 0.0 0.01 14.7 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.14 CCF38020.1 - 0.062 11.9 0.0 0.11 11.1 0.0 1.5 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family HRDC PF00570.18 CCF38020.1 - 0.24 11.1 1.6 2.8 7.7 0.3 2.4 2 0 0 2 2 2 0 HRDC domain Abhydrolase_6 PF12697.2 CCF38021.1 - 2.7e-09 37.2 0.8 2.9e-09 37.1 0.6 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF38021.1 - 8.9e-09 35.2 0.3 9.6e-09 35.1 0.2 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF38021.1 - 1.1e-08 34.6 0.1 1.2e-08 34.5 0.0 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.13 CCF38021.1 - 8.6e-08 31.9 0.4 8.6e-08 31.9 0.2 1.0 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.3 CCF38021.1 - 9.9e-06 25.3 0.0 1.2e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Putative lysophospholipase p450 PF00067.17 CCF38023.1 - 2.8e-51 174.5 0.0 3.8e-51 174.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 ketoacyl-synt PF00109.21 CCF38024.1 - 6.1e-54 183.1 0.1 6.9e-54 182.9 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.18 CCF38024.1 - 4.9e-05 22.4 0.0 7.9e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 CCF38024.1 - 0.001 18.6 0.4 0.0025 17.4 0.3 1.6 1 1 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III STAS_2 PF13466.1 CCF38025.1 - 0.11 12.5 0.0 0.14 12.2 0.0 1.1 1 0 0 1 1 1 0 STAS domain UPF0139 PF03669.8 CCF38026.1 - 0.00016 21.1 0.0 0.00021 20.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) Malic_M PF03949.10 CCF38028.1 - 0.02 14.4 0.2 0.027 14.0 0.2 1.1 1 0 0 1 1 1 0 Malic enzyme, NAD binding domain Tir_receptor_C PF07489.6 CCF38028.1 - 0.036 13.8 1.9 0.046 13.4 1.3 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Pro-kuma_activ PF09286.6 CCF38029.1 - 8.7e-38 129.5 0.1 4e-37 127.4 0.0 1.9 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 CCF38029.1 - 9.8e-07 28.1 0.1 1.5e-06 27.5 0.1 1.2 1 0 0 1 1 1 1 Subtilase family Glyco_hydro_67N PF03648.9 CCF38031.1 - 0.043 13.8 0.1 0.22 11.5 0.1 2.0 1 1 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus TPT PF03151.11 CCF38035.1 - 1.1e-10 41.3 3.7 1.3e-10 41.1 2.6 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.15 CCF38035.1 - 2.8e-05 24.1 2.5 3.5e-05 23.8 1.7 1.1 1 0 0 1 1 1 1 EamA-like transporter family UAA PF08449.6 CCF38035.1 - 0.00061 18.8 2.2 0.00072 18.5 1.6 1.1 1 0 0 1 1 1 1 UAA transporter family PHO4 PF01384.15 CCF38035.1 - 0.0018 16.9 2.8 0.0025 16.5 1.9 1.2 1 1 0 1 1 1 1 Phosphate transporter family Peptidase_A24 PF01478.13 CCF38035.1 - 0.16 12.1 5.9 8.3 6.6 4.1 2.4 1 1 0 1 1 1 0 Type IV leader peptidase family PNP_UDP_1 PF01048.15 CCF38036.1 - 1.1e-15 57.2 0.9 2.3e-14 52.9 0.7 2.2 1 1 0 1 1 1 1 Phosphorylase superfamily WD40 PF00400.27 CCF38037.1 - 7.3e-46 152.4 27.8 2e-11 43.3 0.0 9.5 9 0 0 9 9 9 6 WD domain, G-beta repeat NACHT PF05729.7 CCF38037.1 - 2.6e-18 66.2 0.0 4.9e-18 65.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain eIF2A PF08662.6 CCF38037.1 - 6e-06 26.1 4.3 0.19 11.3 0.1 3.4 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 CCF38037.1 - 0.00066 17.9 8.7 0.063 11.4 0.1 4.4 3 1 1 4 4 4 2 Nucleoporin Nup120/160 DUF1513 PF07433.6 CCF38037.1 - 0.0062 15.4 3.5 21 3.8 0.0 5.0 3 1 1 5 5 5 0 Protein of unknown function (DUF1513) AAA_19 PF13245.1 CCF38037.1 - 0.041 13.6 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain AAA_22 PF13401.1 CCF38037.1 - 0.051 13.7 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Germane PF10646.4 CCF38037.1 - 0.15 12.2 0.0 1.1 9.4 0.0 2.3 2 1 0 2 2 2 0 Sporulation and spore germination zf-C2H2 PF00096.21 CCF38038.1 - 0.0011 19.2 0.8 0.0011 19.2 0.5 4.4 5 0 0 5 5 5 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF38038.1 - 0.024 14.9 0.9 0.024 14.9 0.6 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CCF38038.1 - 0.25 11.5 0.1 0.25 11.5 0.1 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding MutS_I PF01624.15 CCF38039.1 - 1.1e-16 60.8 0.3 1.5e-16 60.4 0.2 1.2 1 0 0 1 1 1 1 MutS domain I Pex14_N PF04695.8 CCF38041.1 - 0.076 13.0 5.5 0.24 11.4 3.8 1.9 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PAT1 PF09770.4 CCF38041.1 - 0.96 7.6 10.2 1.3 7.2 7.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 p450 PF00067.17 CCF38042.1 - 4.9e-23 81.3 0.0 5.3e-23 81.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Esterase_phd PF10503.4 CCF38043.1 - 8.4e-23 80.7 1.0 1.3e-22 80.1 0.7 1.2 1 0 0 1 1 1 1 Esterase PHB depolymerase CBM_1 PF00734.13 CCF38043.1 - 8.9e-14 50.8 3.4 8.9e-14 50.8 2.3 2.3 2 0 0 2 2 2 1 Fungal cellulose binding domain Peptidase_S9 PF00326.16 CCF38043.1 - 1.9e-10 40.3 2.2 2.9e-10 39.7 1.5 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CCF38043.1 - 2.1e-06 27.5 0.1 3.2e-06 26.9 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF38043.1 - 0.0033 17.3 0.0 0.0085 15.9 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF38043.1 - 0.0043 16.6 0.0 0.0059 16.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.15 CCF38043.1 - 0.015 14.6 0.4 0.023 14.1 0.3 1.4 1 0 0 1 1 1 0 Putative esterase Abhydrolase_3 PF07859.8 CCF38043.1 - 0.054 13.0 0.1 0.086 12.4 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold CMAS PF02353.15 CCF38046.1 - 1.5e-24 86.5 0.1 1.7e-24 86.3 0.1 1.0 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 CCF38046.1 - 0.0026 17.5 0.0 0.004 16.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain RRM_5 PF13893.1 CCF38047.1 - 5.9e-06 26.0 0.0 6.4e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CCF38047.1 - 0.008 15.7 0.0 0.0087 15.6 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF38047.1 - 0.018 15.0 0.0 0.021 14.8 0.0 1.1 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) STAS PF01740.16 CCF38048.1 - 1.5e-10 40.4 0.0 2.3e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.1 CCF38048.1 - 0.003 17.5 0.2 0.003 17.5 0.2 2.3 2 0 0 2 2 2 1 STAS domain DNA_pol_B_thumb PF14791.1 CCF38050.1 - 9.3e-21 73.2 0.0 2.1e-20 72.1 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_B_palm PF14792.1 CCF38050.1 - 1e-14 54.4 0.0 2.2e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm HHH_8 PF14716.1 CCF38050.1 - 2.2e-08 34.1 0.0 4.1e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.4 CCF38050.1 - 0.00022 20.6 0.1 0.00067 19.1 0.0 1.8 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda NTP_transf_2 PF01909.18 CCF38050.1 - 0.0092 16.2 0.0 0.021 15.1 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain TFIIE_alpha PF02002.12 CCF38051.1 - 1e-13 50.6 0.2 2.5e-13 49.4 0.1 1.7 1 0 0 1 1 1 1 TFIIE alpha subunit DUF4407 PF14362.1 CCF38051.1 - 0.017 14.1 3.1 0.023 13.6 2.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-FPG_IleRS PF06827.9 CCF38051.1 - 0.034 13.7 0.9 3.5 7.3 0.1 2.4 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS E1-E2_ATPase PF00122.15 CCF38052.1 - 5.3e-50 169.5 6.7 9.5e-50 168.7 4.7 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 CCF38052.1 - 3.3e-25 89.7 0.3 6.5e-25 88.8 0.2 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 CCF38052.1 - 2.7e-12 47.2 0.0 5.6e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CCF38052.1 - 1.2e-06 28.3 0.2 0.00012 21.7 0.1 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 CCF38052.1 - 0.0018 18.3 2.3 0.013 15.6 0.1 2.8 2 0 0 2 2 2 1 Heavy-metal-associated domain HAD_2 PF13419.1 CCF38052.1 - 0.14 12.3 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DUF3278 PF11683.3 CCF38052.1 - 7.8 6.5 5.8 35 4.4 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3278) Amidohydro_2 PF04909.9 CCF38053.1 - 1.2e-20 74.2 0.0 1.9e-20 73.5 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase Spt5-NGN PF03439.8 CCF38053.1 - 0.15 11.8 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 Early transcription elongation factor of RNA pol II, NGN section Sec3_C PF09763.4 CCF38054.1 - 0.25 9.4 3.9 0.26 9.3 2.7 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 CDC45 PF02724.9 CCF38054.1 - 0.89 7.5 7.4 1.1 7.1 5.2 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4614 PF15391.1 CCF38054.1 - 1.2 8.8 22.9 0.17 11.6 9.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) DUF572 PF04502.8 CCF38054.1 - 1.7 7.7 9.7 2.2 7.4 6.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) HD PF01966.17 CCF38055.1 - 5.2e-07 29.7 0.7 1.2e-06 28.5 0.2 1.8 2 0 0 2 2 2 1 HD domain SRI PF08236.6 CCF38055.1 - 0.012 15.5 0.1 0.089 12.7 0.1 2.1 2 0 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain F-box-like PF12937.2 CCF38057.1 - 2e-05 24.1 0.7 0.00021 20.9 0.6 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 CCF38057.1 - 2.7e-05 23.6 1.0 7.2e-05 22.3 0.7 1.7 1 0 0 1 1 1 1 F-box domain Fasciclin PF02469.17 CCF38058.1 - 9.3e-30 103.2 0.2 8.5e-20 71.0 0.0 2.5 2 1 0 2 2 2 2 Fasciclin domain MTHFR PF02219.12 CCF38058.1 - 0.093 11.7 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Methylenetetrahydrofolate reductase MFS_1 PF07690.11 CCF38059.1 - 6.4e-39 133.6 17.6 1e-38 132.9 8.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF38059.1 - 2.4e-13 49.4 0.8 2.4e-13 49.4 0.6 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_2 PF13347.1 CCF38059.1 - 0.00021 19.8 22.3 0.00098 17.6 1.1 2.6 3 0 0 3 3 3 2 MFS/sugar transport protein NPR3 PF03666.8 CCF38060.1 - 0.094 11.2 1.7 0.15 10.5 1.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 adh_short PF00106.20 CCF38061.1 - 4.5e-06 26.6 0.4 5.6e-06 26.3 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF38061.1 - 0.00057 19.7 0.0 0.0008 19.2 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF38061.1 - 0.086 12.4 0.1 0.12 12.0 0.1 1.1 1 0 0 1 1 1 0 KR domain Kp4 PF09044.5 CCF38062.1 - 2.5e-36 124.2 1.6 3.4e-36 123.8 1.1 1.2 1 0 0 1 1 1 1 Kp4 MU117 PF15474.1 CCF38062.1 - 0.01 16.2 0.6 0.015 15.7 0.4 1.3 1 0 0 1 1 1 0 Meiotically up-regulated gene family PTR2 PF00854.16 CCF38063.1 - 7.5e-38 130.2 15.0 5e-26 91.3 2.0 2.9 3 0 0 3 3 3 2 POT family zf-RanBP PF00641.13 CCF38064.1 - 2.1e-18 65.1 13.3 7.1e-11 41.0 1.1 2.3 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.17 CCF38064.1 - 1.6e-08 34.0 0.0 3.4e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.19 CCF38064.1 - 6.6e-07 29.7 0.0 1.1e-06 29.0 0.0 1.3 1 0 0 1 1 1 1 Exonuclease RRM_6 PF14259.1 CCF38064.1 - 1.5e-05 24.8 0.0 3e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DZR PF12773.2 CCF38064.1 - 3.6 7.4 10.9 0.72 9.7 0.8 2.4 2 0 0 2 2 2 0 Double zinc ribbon HET PF06985.6 CCF38065.1 - 0.0032 17.6 0.0 0.012 15.7 0.0 1.9 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) RasGAP PF00616.14 CCF38065.1 - 0.051 13.2 0.1 0.082 12.5 0.0 1.2 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase CBM-like PF14683.1 CCF38066.1 - 1.1e-29 103.2 0.0 1.9e-29 102.4 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.1 CCF38066.1 - 6.6e-19 67.8 0.1 6.6e-19 67.8 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.1 CCF38066.1 - 1.2e-06 28.4 0.5 0.0016 18.4 0.1 2.5 2 0 0 2 2 2 2 Carboxypeptidase regulatory-like domain Vps35 PF03635.12 CCF38068.1 - 0 1021.4 0.0 0 1021.2 0.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 RIH_assoc PF08454.6 CCF38068.1 - 0.13 11.9 1.8 0.92 9.1 0.1 3.3 4 0 0 4 4 4 0 RyR and IP3R Homology associated Pkinase PF00069.20 CCF38070.1 - 2.6e-22 79.2 0.0 2e-21 76.3 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF38070.1 - 2e-09 36.9 0.0 1.5e-05 24.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Lipase_GDSL_2 PF13472.1 CCF38072.1 - 1.1e-17 64.7 0.5 1.4e-17 64.4 0.4 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 CCF38072.1 - 1.7e-09 37.8 0.4 2.7e-09 37.2 0.2 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DHquinase_I PF01487.10 CCF38072.1 - 0.045 13.3 0.0 0.068 12.8 0.0 1.2 1 0 0 1 1 1 0 Type I 3-dehydroquinase DUF637 PF04830.8 CCF38072.1 - 0.37 10.4 5.1 1 9.0 3.6 1.9 1 1 0 1 1 1 0 Possible hemagglutinin (DUF637) DUF3328 PF11807.3 CCF38074.1 - 6e-41 140.5 0.5 8.1e-41 140.0 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF2636 PF11120.3 CCF38075.1 - 0.019 14.4 0.0 28 4.3 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2636) Ribosomal_S11 PF00411.14 CCF38075.1 - 0.023 14.8 1.3 0.63 10.2 0.2 2.2 2 0 0 2 2 2 0 Ribosomal protein S11 DUF1515 PF07439.6 CCF38075.1 - 0.033 14.0 0.7 0.15 11.8 0.2 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1515) Ldh_1_N PF00056.18 CCF38075.1 - 0.13 12.1 0.5 2.6 7.8 0.2 2.1 1 1 2 3 3 3 0 lactate/malate dehydrogenase, NAD binding domain SUN PF03856.8 CCF38076.1 - 3.5e-70 236.1 14.9 4.7e-70 235.7 10.3 1.1 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) IER PF05760.7 CCF38076.1 - 7.5 6.3 10.8 14 5.5 7.5 1.4 1 0 0 1 1 1 0 Immediate early response protein (IER) PCI PF01399.22 CCF38077.1 - 0.0072 16.6 0.0 0.081 13.2 0.0 2.3 2 0 0 2 2 2 1 PCI domain Thiolase_N PF00108.18 CCF38078.1 - 8.9e-93 310.0 0.3 1.3e-92 309.4 0.2 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 CCF38078.1 - 8e-37 125.4 1.5 1.2e-36 124.7 0.4 1.8 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 CCF38078.1 - 0.00022 20.8 0.3 0.00051 19.5 0.2 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain UQ_con PF00179.21 CCF38079.1 - 1.1e-51 173.8 0.0 1.3e-51 173.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CCF38079.1 - 1e-06 28.5 0.0 1.2e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 CCF38079.1 - 0.017 14.9 0.1 0.035 14.0 0.1 1.6 1 1 0 1 1 1 0 RWD domain Kinesin PF00225.18 CCF38080.1 - 1.9e-113 378.6 0.3 5.3e-113 377.1 0.2 1.8 1 0 0 1 1 1 1 Kinesin motor domain Mito_carr PF00153.22 CCF38081.1 - 0.00063 19.4 0.1 0.69 9.6 0.0 2.4 2 0 0 2 2 2 2 Mitochondrial carrier protein LCM PF04072.9 CCF38082.1 - 3.7e-20 72.2 0.0 6.9e-20 71.3 0.0 1.4 2 0 0 2 2 2 1 Leucine carboxyl methyltransferase F-box-like PF12937.2 CCF38083.1 - 0.0017 18.0 0.1 0.0036 17.0 0.1 1.6 1 0 0 1 1 1 1 F-box-like Metallophos PF00149.23 CCF38084.1 - 1.1e-08 34.7 0.7 2.1e-08 33.8 0.5 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase SnoaL_2 PF12680.2 CCF38085.1 - 5.5e-07 29.9 0.0 8.2e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain LigB PF02900.13 CCF38087.1 - 8.9e-41 139.6 0.0 1.1e-40 139.3 0.0 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase FAD_binding_3 PF01494.14 CCF38088.1 - 4.2e-21 75.4 0.7 8.6e-21 74.3 0.5 1.4 1 1 0 1 1 1 1 FAD binding domain ADC PF06314.6 CCF38088.1 - 7.2e-16 58.2 0.1 3.6e-15 55.9 0.0 1.9 1 1 0 1 1 1 1 Acetoacetate decarboxylase (ADC) DAO PF01266.19 CCF38088.1 - 5.7e-08 32.0 5.1 1.7e-06 27.2 1.3 2.4 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CCF38088.1 - 2.4e-07 29.9 2.0 2.2e-06 26.7 0.7 2.3 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.1 CCF38088.1 - 1.1e-06 28.5 0.3 3.1e-06 27.1 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF38088.1 - 1.3e-05 25.1 0.2 3.5e-05 23.7 0.2 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 CCF38088.1 - 0.00019 20.6 2.6 0.0003 19.9 0.7 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.17 CCF38088.1 - 0.0011 17.8 0.5 0.0018 17.2 0.3 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.12 CCF38088.1 - 0.0018 17.4 0.2 0.0031 16.6 0.1 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.9 CCF38088.1 - 0.0019 16.7 0.2 0.0027 16.2 0.2 1.2 1 0 0 1 1 1 1 HI0933-like protein AlaDh_PNT_C PF01262.16 CCF38088.1 - 0.047 13.2 0.3 0.091 12.3 0.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.22 CCF38088.1 - 0.064 13.6 0.5 0.13 12.7 0.4 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF38088.1 - 0.12 10.9 0.2 0.21 10.2 0.1 1.3 1 0 0 1 1 1 0 Tryptophan halogenase DUF1279 PF06916.8 CCF38089.1 - 2.2e-29 101.6 0.0 2e-28 98.5 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1279) DUF726 PF05277.7 CCF38090.1 - 8.6e-115 383.2 0.1 1.1e-114 382.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Abhydrolase_6 PF12697.2 CCF38090.1 - 3.2e-05 23.9 0.6 6.3e-05 22.9 0.1 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Thioesterase PF00975.15 CCF38090.1 - 0.00014 22.1 0.0 0.00031 21.0 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_5 PF12695.2 CCF38090.1 - 0.00056 19.6 0.0 0.0014 18.4 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family PE-PPE PF08237.6 CCF38090.1 - 0.057 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 PE-PPE domain Cutinase PF01083.17 CCF38090.1 - 0.062 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Cutinase Noc2 PF03715.8 CCF38091.1 - 5.2e-123 409.6 0.9 7.1e-123 409.2 0.6 1.2 1 0 0 1 1 1 1 Noc2p family BUD22 PF09073.5 CCF38091.1 - 0.0089 15.1 14.1 0.012 14.6 9.7 1.2 1 0 0 1 1 1 1 BUD22 TFIIA PF03153.8 CCF38091.1 - 0.019 14.9 8.7 0.024 14.5 6.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit adh_short PF00106.20 CCF38091.1 - 0.096 12.5 0.2 2.2 8.1 0.0 2.3 2 0 0 2 2 2 0 short chain dehydrogenase Astro_capsid PF03115.9 CCF38091.1 - 0.33 9.1 4.0 0.49 8.5 2.8 1.2 1 0 0 1 1 1 0 Astrovirus capsid protein precursor DUF1510 PF07423.6 CCF38091.1 - 1.6 8.0 15.4 2.1 7.6 10.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) PPP4R2 PF09184.6 CCF38091.1 - 2.3 7.6 18.0 3.2 7.2 12.5 1.2 1 0 0 1 1 1 0 PPP4R2 FYDLN_acid PF09538.5 CCF38091.1 - 2.7 8.6 24.1 4.2 7.9 16.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) TauD PF02668.11 CCF38092.1 - 6.9e-26 91.4 1.3 9.9e-26 90.9 0.9 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.5 CCF38092.1 - 0.028 13.3 0.0 0.045 12.6 0.0 1.2 1 0 0 1 1 1 0 CsiD Cys_rich_CPCC PF14206.1 CCF38092.1 - 0.14 11.7 0.0 0.65 9.5 0.0 2.0 2 0 0 2 2 2 0 Cysteine-rich CPCC Fungal_trans_2 PF11951.3 CCF38093.1 - 1.6e-08 33.6 0.1 8e-07 27.9 0.0 2.4 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF38093.1 - 1.7e-05 24.5 11.0 2.9e-05 23.8 7.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FlgM PF04316.8 CCF38093.1 - 0.023 14.6 0.0 0.068 13.1 0.0 1.8 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM PP2C PF00481.16 CCF38094.1 - 1.1e-62 211.7 0.3 1.3e-51 175.4 0.3 3.1 1 1 1 2 2 2 2 Protein phosphatase 2C Actin PF00022.14 CCF38095.1 - 7.7e-116 386.7 0.0 8.6e-116 386.5 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 CCF38095.1 - 0.027 13.0 0.0 0.19 10.2 0.0 2.1 1 1 0 1 1 1 0 MreB/Mbl protein Cutinase PF01083.17 CCF38096.1 - 2.1e-33 115.5 0.0 2.8e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 Cutinase DUF2235 PF09994.4 CCF38096.1 - 0.017 14.4 0.0 0.023 14.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) Lipase_3 PF01764.20 CCF38096.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) AA_permease PF00324.16 CCF38097.1 - 2.4e-120 402.1 37.5 3e-120 401.7 26.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF38097.1 - 2.9e-28 98.5 40.4 3.5e-28 98.3 28.0 1.0 1 0 0 1 1 1 1 Amino acid permease Erf4 PF10256.4 CCF38098.1 - 0.02 14.7 0.0 0.041 13.7 0.0 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family HET PF06985.6 CCF38099.1 - 1.2e-31 109.6 0.1 4.5e-31 107.8 0.0 2.0 2 1 0 2 2 2 1 Heterokaryon incompatibility protein (HET) FAD_binding_4 PF01565.18 CCF38100.1 - 1.1e-15 57.3 4.0 1.1e-15 57.3 2.8 1.9 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.7 CCF38100.1 - 1.5e-12 47.1 0.9 4.1e-12 45.7 0.1 2.1 2 0 0 2 2 2 1 Berberine and berberine like Cytokin-bind PF09265.5 CCF38100.1 - 0.22 10.6 0.8 0.51 9.4 0.2 1.6 1 1 1 2 2 2 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Sfi1 PF08457.5 CCF38101.1 - 0.0017 16.8 6.4 0.0022 16.4 4.5 1.1 1 0 0 1 1 1 1 Sfi1 spindle body protein p450 PF00067.17 CCF38104.1 - 2.1e-58 198.0 0.0 2.7e-58 197.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HAMP PF00672.20 CCF38105.1 - 1.7e-48 162.6 23.4 1.4e-10 41.1 0.3 7.4 7 0 0 7 7 7 6 HAMP domain HATPase_c PF02518.21 CCF38105.1 - 3.1e-30 104.1 0.5 1.1e-29 102.4 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 CCF38105.1 - 1.9e-28 98.6 0.6 5.4e-26 90.8 0.1 2.8 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.20 CCF38105.1 - 4e-18 65.1 0.5 4e-18 65.1 0.4 4.9 5 0 0 5 5 5 1 His Kinase A (phospho-acceptor) domain Gp-FAR-1 PF05823.7 CCF38105.1 - 0.0039 17.1 0.0 10 6.0 0.0 4.0 4 1 0 4 4 4 2 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF883 PF05957.8 CCF38105.1 - 0.025 14.9 15.4 1.2 9.6 0.3 6.3 5 2 2 7 7 7 0 Bacterial protein of unknown function (DUF883) NAAA-beta PF15508.1 CCF38105.1 - 0.14 12.4 4.7 7.6 6.9 0.1 5.5 4 2 2 6 6 6 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Syntaphilin PF15290.1 CCF38105.1 - 4.1 6.8 14.1 4.9 6.5 1.3 4.3 5 1 0 5 5 5 0 Golgi-localised syntaxin-1-binding clamp DUF3185 PF11381.3 CCF38106.1 - 0.64 9.8 8.8 3 7.6 0.7 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3185) TPR_MLP1_2 PF07926.7 CCF38107.1 - 0.0026 17.5 7.2 0.0026 17.5 5.0 2.4 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein Oxysterol_BP PF01237.13 CCF38107.1 - 0.21 10.0 3.6 0.3 9.5 2.5 1.4 1 0 0 1 1 1 0 Oxysterol-binding protein TMCO5 PF14992.1 CCF38107.1 - 0.49 9.4 12.5 0.86 8.6 8.7 1.3 1 0 0 1 1 1 0 TMCO5 family ADIP PF11559.3 CCF38107.1 - 4.1 7.2 21.0 1.6 8.6 4.3 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding LrgA PF03788.9 CCF38108.1 - 0.71 9.6 8.7 0.29 10.8 3.0 2.2 1 1 1 2 2 2 0 LrgA family DUF4229 PF14012.1 CCF38108.1 - 1.1 9.2 6.9 0.38 10.6 2.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) Corona_S2 PF01601.11 CCF38110.1 - 0.093 10.8 17.1 0.14 10.2 11.8 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein GP41 PF00517.12 CCF38110.1 - 0.12 11.9 1.0 0.17 11.3 0.7 1.2 1 0 0 1 1 1 0 Retroviral envelope protein Tannase PF07519.6 CCF38111.1 - 1.2e-87 294.5 0.6 1.8e-87 294.0 0.4 1.2 1 0 0 1 1 1 1 Tannase and feruloyl esterase MFS_1 PF07690.11 CCF38113.1 - 6.3e-05 21.8 0.2 8.1e-05 21.4 0.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF38113.1 - 0.088 12.6 0.1 0.22 11.3 0.0 1.7 1 0 0 1 1 1 0 MFS_1 like family MFS_1 PF07690.11 CCF38114.1 - 4.6e-06 25.5 0.1 6.3e-06 25.1 0.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Cu_amine_oxid PF01179.15 CCF38115.1 - 0.1 11.2 0.1 0.17 10.5 0.1 1.2 1 0 0 1 1 1 0 Copper amine oxidase, enzyme domain Sugar_tr PF00083.19 CCF38117.1 - 1.6e-101 340.1 31.0 1.9e-101 339.8 21.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF38117.1 - 3.4e-34 118.1 29.4 3.4e-34 118.1 20.4 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Erv26 PF04148.8 CCF38119.1 - 1.4e-49 168.3 0.3 1.7e-49 168.1 0.2 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 DUF3377 PF11857.3 CCF38119.1 - 0.0051 16.4 0.0 0.009 15.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) DUF1970 PF09301.5 CCF38119.1 - 0.14 12.2 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1970) Orthopox_C10L PF07020.6 CCF38120.1 - 2 9.0 6.6 3.9 8.0 4.6 1.7 1 1 0 1 1 1 0 Orthopoxvirus C10L protein adh_short PF00106.20 CCF38121.1 - 2.1e-14 53.7 0.0 3.2e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.10 CCF38121.1 - 0.0019 17.1 0.0 0.0025 16.7 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short_C2 PF13561.1 CCF38121.1 - 0.0021 17.9 0.0 0.0029 17.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Vac14_Fab1_bd PF12755.2 CCF38123.1 - 1.1e-45 153.9 0.0 3.6e-44 149.1 0.0 2.2 2 0 0 2 2 2 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 CCF38123.1 - 1.5e-07 31.6 1.3 1e-05 25.8 0.0 3.4 3 0 0 3 3 3 1 HEAT-like repeat HEAT PF02985.17 CCF38123.1 - 8.1e-07 28.6 3.0 4e-05 23.3 0.0 3.5 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.1 CCF38123.1 - 1.2e-05 25.5 0.0 0.00049 20.3 0.0 2.6 2 0 0 2 2 2 1 HEAT repeats Cnd1 PF12717.2 CCF38123.1 - 0.0056 16.5 0.0 0.15 11.8 0.0 2.4 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.18 CCF38123.1 - 0.039 13.7 0.0 0.17 11.7 0.0 2.1 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat DUF2454 PF10521.4 CCF38123.1 - 0.098 11.6 0.0 11 4.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2454) Aldo_ket_red PF00248.16 CCF38124.1 - 6.8e-51 172.7 0.0 8e-51 172.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family BTG PF07742.7 CCF38124.1 - 0.062 12.8 0.4 3.4 7.2 0.0 2.6 2 1 1 3 3 3 0 BTG family CENP-B_dimeris PF09026.5 CCF38125.1 - 0.019 15.1 8.4 0.047 13.9 5.8 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sigma70_ner PF04546.8 CCF38125.1 - 0.085 12.4 3.8 0.16 11.5 2.6 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region GCIP PF13324.1 CCF38125.1 - 0.82 8.8 4.2 1.3 8.1 2.9 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DUF2457 PF10446.4 CCF38125.1 - 2.2 6.8 16.6 3.7 6.1 11.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PBP1_TM PF14812.1 CCF38125.1 - 4.6 7.6 11.5 11 6.4 8.0 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pkinase PF00069.20 CCF38126.1 - 2.3e-63 213.7 0.0 3.8e-63 213.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF38126.1 - 5.2e-43 146.9 0.0 8.1e-43 146.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.23 CCF38126.1 - 4.9e-16 58.8 0.0 2.3e-15 56.7 0.0 2.3 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.1 CCF38126.1 - 1.5e-07 30.7 0.0 2.6e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CCF38126.1 - 0.0073 16.0 0.3 0.13 12.0 0.0 2.6 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 CCF38126.1 - 0.14 11.2 0.1 0.48 9.4 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DSHCT PF08148.7 CCF38126.1 - 0.16 11.2 0.0 0.29 10.3 0.0 1.4 1 0 0 1 1 1 0 DSHCT (NUC185) domain AAA PF00004.24 CCF38127.1 - 1.5e-17 64.0 0.0 2.8e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF38127.1 - 0.00071 19.6 0.1 0.0021 18.0 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 CCF38127.1 - 0.0046 17.7 0.1 0.071 13.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CCF38127.1 - 0.0099 16.0 0.4 0.12 12.5 0.1 2.4 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.9 CCF38127.1 - 0.03 14.0 0.0 0.071 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 CCF38127.1 - 0.032 13.9 0.3 0.094 12.4 0.2 1.7 1 0 0 1 1 1 0 Part of AAA domain CPT PF07931.7 CCF38127.1 - 0.087 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein TATR PF03430.8 CCF38127.1 - 4.2 5.8 13.2 6.4 5.2 9.2 1.3 1 0 0 1 1 1 0 Trans-activating transcriptional regulator SURF4 PF02077.10 CCF38128.1 - 1.7e-98 329.2 8.4 1.9e-98 329.1 5.8 1.0 1 0 0 1 1 1 1 SURF4 family Peptidase_A24 PF01478.13 CCF38128.1 - 0.027 14.6 15.2 0.048 13.8 0.9 2.7 2 1 0 2 2 2 0 Type IV leader peptidase family Halogen_Hydrol PF10112.4 CCF38128.1 - 4.5 6.6 5.7 3.1 7.1 0.6 2.6 3 0 0 3 3 3 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Pacifastin_I PF05375.8 CCF38129.1 - 0.89 9.1 5.1 0.24 10.9 1.2 1.7 2 0 0 2 2 2 0 Pacifastin inhibitor (LCMII) zf-H2C2_2 PF13465.1 CCF38131.1 - 2.3e-20 71.7 27.9 5.6e-08 32.6 0.4 5.0 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.21 CCF38131.1 - 4.4e-20 70.7 31.0 1.4e-05 25.1 0.1 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF38131.1 - 1.8e-10 40.3 26.9 0.00053 20.1 1.2 4.6 4 0 0 4 4 4 3 C2H2-type zinc finger zf-TRAF PF02176.13 CCF38131.1 - 0.0061 16.9 15.0 0.054 13.8 2.0 3.3 1 1 2 3 3 3 2 TRAF-type zinc finger Ogr_Delta PF04606.7 CCF38131.1 - 0.012 15.3 1.2 2.7 7.7 0.1 2.6 1 1 1 2 2 2 0 Ogr/Delta-like zinc finger zf-met PF12874.2 CCF38131.1 - 0.024 14.8 1.0 0.024 14.8 0.7 4.8 5 1 1 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 CCF38131.1 - 0.05 13.7 14.6 1.5 9.0 0.4 4.6 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding CHORD PF04968.7 CCF38131.1 - 3.3 8.0 17.0 4 7.7 0.2 4.3 1 1 3 4 4 4 0 CHORD CFEM PF05730.6 CCF38132.1 - 4.2e-14 52.1 6.8 7.3e-14 51.3 4.7 1.4 1 0 0 1 1 1 1 CFEM domain RhodobacterPufX PF11511.3 CCF38132.1 - 2.6 7.4 5.9 25 4.3 0.2 2.9 2 0 0 2 2 2 0 Intrinsic membrane protein PufX p450 PF00067.17 CCF38133.1 - 3e-68 230.4 0.0 3.8e-68 230.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 NmrA PF05368.8 CCF38134.1 - 1.6e-19 70.1 0.2 1.9e-19 69.8 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.20 CCF38134.1 - 3.5e-06 27.0 0.3 5.7e-06 26.3 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF38134.1 - 1.9e-05 24.3 0.0 2.7e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF38134.1 - 2.1e-05 24.6 0.2 3.3e-05 23.9 0.1 1.3 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF38134.1 - 2.6e-05 23.7 0.1 7.4e-05 22.2 0.1 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 CCF38134.1 - 0.0031 16.4 0.0 0.005 15.8 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 CCF38134.1 - 0.014 14.0 0.1 0.021 13.5 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Saccharop_dh PF03435.13 CCF38134.1 - 0.017 14.1 0.3 0.03 13.3 0.2 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase F420_oxidored PF03807.12 CCF38134.1 - 0.025 15.0 0.3 0.27 11.6 0.1 2.3 1 1 1 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent CoA_binding_3 PF13727.1 CCF38134.1 - 0.026 14.3 0.1 0.04 13.7 0.1 1.3 1 0 0 1 1 1 0 CoA-binding domain Polysacc_synt_2 PF02719.10 CCF38134.1 - 0.026 13.4 0.0 0.037 12.9 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DapB_N PF01113.15 CCF38134.1 - 0.045 13.6 0.5 0.29 11.0 0.3 2.2 1 1 1 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Borrelia_lipo_1 PF05714.6 CCF38134.1 - 0.06 12.4 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein zf-C2H2_2 PF12756.2 CCF38135.1 - 4.5e-05 23.4 7.2 0.024 14.7 0.6 3.1 2 1 1 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 CCF38135.1 - 0.00017 21.6 0.8 0.00017 21.6 0.6 3.4 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 CCF38135.1 - 0.0004 20.5 16.1 0.77 10.2 1.3 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF38135.1 - 0.00075 19.7 22.7 0.044 14.1 1.6 3.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-met PF12874.2 CCF38135.1 - 0.0015 18.6 14.8 0.0044 17.1 1.3 4.3 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.1 CCF38135.1 - 0.008 16.3 0.7 0.008 16.3 0.5 3.2 3 0 0 3 3 2 1 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.1 CCF38135.1 - 0.028 14.7 17.6 0.36 11.1 0.9 3.5 3 0 0 3 3 3 0 Zinc-finger double domain zf-Di19 PF05605.7 CCF38135.1 - 0.074 13.1 1.2 0.074 13.1 0.8 2.7 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook PF04423.9 CCF38135.1 - 0.088 12.2 0.1 0.45 10.0 0.0 2.2 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-FCS PF06467.9 CCF38135.1 - 2 8.1 6.4 21 4.8 0.1 3.0 2 1 1 3 3 3 0 MYM-type Zinc finger with FCS sequence motif DUF2024 PF09630.5 CCF38135.1 - 3.7 7.3 6.1 6.7 6.4 1.2 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF2024) TFX_C PF14601.1 CCF38136.1 - 0.014 15.1 0.0 0.12 12.1 0.0 2.1 2 0 0 2 2 2 0 DNA_binding protein, TFX, C-term TPR_11 PF13414.1 CCF38137.1 - 2.5e-07 30.2 4.1 0.00028 20.4 0.0 2.3 2 0 0 2 2 2 2 TPR repeat TPR_16 PF13432.1 CCF38137.1 - 6.1e-05 23.5 4.0 0.0051 17.4 0.8 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 CCF38137.1 - 0.00052 19.7 10.3 0.0074 16.1 1.1 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat SET PF00856.23 CCF38137.1 - 0.0065 16.7 0.1 0.02 15.2 0.0 1.8 1 0 0 1 1 1 1 SET domain TPR_9 PF13371.1 CCF38137.1 - 0.014 15.2 1.1 0.24 11.2 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 CCF38137.1 - 0.021 14.4 0.8 5.3 6.8 0.5 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat CENP-L PF13092.1 CCF38137.1 - 0.028 14.2 0.0 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 TPR_8 PF13181.1 CCF38137.1 - 0.08 12.7 2.7 0.81 9.6 0.2 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 CCF38137.1 - 0.11 12.4 3.7 3.5 7.6 0.1 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 CCF38137.1 - 1.9 9.3 4.6 43 5.1 0.1 4.2 1 1 3 4 4 4 0 Tetratricopeptide repeat MutS_V PF00488.16 CCF38138.1 - 7.3e-81 271.0 0.0 1.5e-80 270.0 0.0 1.5 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.13 CCF38138.1 - 4.3e-37 127.8 2.6 7.7e-37 127.0 1.8 1.4 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.13 CCF38138.1 - 2.6e-06 27.4 0.0 6.4e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.12 CCF38138.1 - 0.0023 17.9 0.0 0.015 15.3 0.0 2.4 2 0 0 2 2 2 1 MutS domain II GFO_IDH_MocA PF01408.17 CCF38141.1 - 4.8e-26 91.6 0.0 7.5e-26 91.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 CCF38141.1 - 2.1e-18 66.2 0.0 3.4e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Semialdhyde_dh PF01118.19 CCF38141.1 - 0.039 14.2 0.0 0.072 13.3 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_3 PF03447.11 CCF38141.1 - 0.14 12.5 0.0 0.28 11.6 0.0 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Methyltransf_23 PF13489.1 CCF38142.1 - 5.3e-12 45.7 0.0 7.5e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF38142.1 - 1.4e-07 31.8 0.0 2.7e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF38142.1 - 3.4e-06 27.3 0.0 8.8e-06 26.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF38142.1 - 0.00016 20.8 0.0 0.00052 19.2 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 CCF38142.1 - 0.00078 19.0 0.0 0.013 15.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF38142.1 - 0.0018 18.6 0.0 0.0067 16.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 CCF38142.1 - 0.0033 17.4 0.0 0.0047 16.9 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_18 PF12847.2 CCF38142.1 - 0.03 14.9 0.1 0.24 12.0 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_8 PF05148.10 CCF38142.1 - 0.031 13.8 0.0 6.6 6.2 0.0 2.3 2 0 0 2 2 2 0 Hypothetical methyltransferase F-box-like PF12937.2 CCF38143.1 - 1.1e-06 28.2 0.6 2.4e-06 27.1 0.0 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 CCF38143.1 - 0.0008 19.0 0.0 0.0024 17.4 0.0 1.9 1 0 0 1 1 1 1 F-box domain HET PF06985.6 CCF38144.1 - 2.4e-23 82.8 0.0 4.1e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Phytochelatin_C PF09328.5 CCF38144.1 - 0.16 11.4 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1984) MaoC_dehydrat_N PF13452.1 CCF38146.1 - 0.00048 19.9 0.0 0.0085 15.8 0.0 2.2 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase GATase_2 PF00310.16 CCF38148.1 - 1.2e-15 57.0 0.0 5.3e-11 41.8 0.0 2.3 1 1 1 2 2 2 2 Glutamine amidotransferases class-II Pribosyltran PF00156.22 CCF38148.1 - 5.4e-15 55.2 0.7 1.1e-14 54.1 0.1 1.7 2 0 0 2 2 2 1 Phosphoribosyl transferase domain GATase_6 PF13522.1 CCF38148.1 - 5.9e-13 48.9 0.0 1.1e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 CCF38148.1 - 1e-08 34.9 0.0 2.2e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain ADH_zinc_N PF00107.21 CCF38148.1 - 0.017 14.6 0.0 3.7 7.1 0.0 2.7 2 0 0 2 2 2 0 Zinc-binding dehydrogenase PRTase_3 PF15610.1 CCF38148.1 - 0.055 12.3 0.0 0.098 11.5 0.0 1.3 1 0 0 1 1 1 0 PRTase ComF-like HET PF06985.6 CCF38149.1 - 1.5e-26 93.2 0.0 3.9e-25 88.6 0.0 2.1 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) RTA1 PF04479.8 CCF38150.1 - 3.3e-33 115.0 10.9 4.6e-33 114.5 7.6 1.1 1 0 0 1 1 1 1 RTA1 like protein ATPase_gene1 PF09527.5 CCF38150.1 - 6 6.7 11.8 5.2 6.9 1.8 2.9 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit (ATPase_gene1) MFS_1 PF07690.11 CCF38151.1 - 3e-19 68.9 12.5 4e-19 68.5 8.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF38151.1 - 1.2e-08 34.0 7.5 1.5e-08 33.6 5.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter ATG22 PF11700.3 CCF38151.1 - 0.003 16.1 5.4 0.0036 15.8 3.8 1.1 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like TRI12 PF06609.8 CCF38151.1 - 0.028 12.6 2.7 0.035 12.2 1.9 1.1 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) AMP-binding PF00501.23 CCF38152.1 - 1.7e-18 66.2 0.0 1.9e-18 66.0 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme Put_Phosphatase PF06888.7 CCF38152.1 - 0.11 11.6 0.0 0.19 10.8 0.0 1.4 1 0 0 1 1 1 0 Putative Phosphatase DUF4470 PF14737.1 CCF38152.1 - 0.12 12.0 0.0 0.43 10.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4470) Amidohydro_2 PF04909.9 CCF38153.1 - 9.1e-47 159.8 0.1 1.1e-46 159.6 0.1 1.0 1 0 0 1 1 1 1 Amidohydrolase Y_phosphatase PF00102.22 CCF38154.1 - 3.9e-61 206.3 0.1 4.7e-33 114.4 0.0 3.2 3 0 0 3 3 3 3 Protein-tyrosine phosphatase Rhodanese PF00581.15 CCF38154.1 - 7.7e-13 48.7 0.0 1.8e-12 47.5 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain Y_phosphatase3 PF13350.1 CCF38154.1 - 0.017 15.3 0.1 0.056 13.7 0.1 1.8 1 0 0 1 1 1 0 Tyrosine phosphatase family DSPc PF00782.15 CCF38154.1 - 0.02 14.5 0.1 0.051 13.1 0.0 1.6 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain AAA PF00004.24 CCF38155.1 - 5.2e-44 149.6 0.0 8.5e-44 148.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CCF38155.1 - 3.1e-08 33.4 0.0 7.5e-08 32.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 CCF38155.1 - 1.2e-07 31.8 0.0 2.2e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 CCF38155.1 - 3.3e-06 27.2 0.0 9.5e-06 25.7 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CCF38155.1 - 4.8e-06 26.7 0.1 0.00025 21.1 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CCF38155.1 - 6.2e-05 23.8 0.0 0.00015 22.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 CCF38155.1 - 7.7e-05 21.8 0.0 0.00013 21.0 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 CCF38155.1 - 0.00014 21.5 0.1 0.00029 20.5 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 CCF38155.1 - 0.00042 19.7 0.0 0.00076 18.9 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.8 CCF38155.1 - 0.00089 18.0 0.0 0.0016 17.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_33 PF13671.1 CCF38155.1 - 0.0014 18.5 0.0 0.0025 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 CCF38155.1 - 0.0017 18.2 0.0 0.0029 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.6 CCF38155.1 - 0.0023 17.5 0.0 0.0074 15.8 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 CCF38155.1 - 0.0024 17.0 0.0 0.0044 16.1 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_28 PF13521.1 CCF38155.1 - 0.0038 17.1 0.0 0.0067 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CCF38155.1 - 0.0058 16.9 0.0 0.028 14.7 0.0 2.3 3 0 0 3 3 2 1 AAA domain Mg_chelatase PF01078.16 CCF38155.1 - 0.0068 15.5 0.0 0.015 14.5 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI KaiC PF06745.8 CCF38155.1 - 0.0072 15.4 0.0 0.017 14.2 0.0 1.6 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.1 CCF38155.1 - 0.017 14.5 0.1 0.081 12.3 0.0 1.9 1 1 1 2 2 2 0 AAA domain PhoH PF02562.11 CCF38155.1 - 0.018 14.2 0.0 0.07 12.3 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein DUF815 PF05673.8 CCF38155.1 - 0.018 13.9 0.0 0.033 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.21 CCF38155.1 - 0.019 14.4 0.0 0.085 12.3 0.0 2.0 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA_24 PF13479.1 CCF38155.1 - 0.021 14.4 0.0 0.041 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 CCF38155.1 - 0.028 14.5 0.0 0.053 13.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase DUF2072 PF09845.4 CCF38155.1 - 0.04 13.8 0.1 0.086 12.7 0.1 1.5 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) Histone PF00125.19 CCF38155.1 - 0.044 13.8 0.0 0.14 12.2 0.0 1.9 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Sigma54_activ_2 PF14532.1 CCF38155.1 - 0.047 13.7 0.0 0.12 12.4 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Parvo_NS1 PF01057.12 CCF38155.1 - 0.048 12.5 0.0 0.086 11.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NB-ARC PF00931.17 CCF38155.1 - 0.076 11.8 0.0 0.14 10.9 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.7 CCF38155.1 - 0.098 12.3 0.0 0.53 9.9 0.0 2.0 1 1 1 2 2 2 0 NACHT domain Na_Ca_ex PF01699.19 CCF38156.1 - 6.6e-31 106.7 25.1 5.6e-19 68.1 7.1 3.9 4 1 0 4 4 4 2 Sodium/calcium exchanger protein DUF307 PF03733.8 CCF38156.1 - 4.1e-14 52.7 11.2 4.1e-14 52.7 7.7 3.8 3 0 0 3 3 3 1 Domain of unknown function (DUF307) Oxidored_molyb PF00174.14 CCF38157.1 - 2.4e-52 176.7 0.0 3.5e-52 176.2 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.11 CCF38157.1 - 1e-20 73.7 0.3 1.7e-20 73.0 0.2 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain SLBB PF10531.4 CCF38157.1 - 0.019 14.8 0.0 3.3 7.6 0.0 2.5 2 0 0 2 2 2 0 SLBB domain GHMP_kinases_C PF08544.8 CCF38158.1 - 1.9e-05 24.7 0.0 2.8e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 GHMP kinases C terminal PfkB PF00294.19 CCF38159.1 - 3.5e-13 49.3 0.0 6.1e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Metallophos PF00149.23 CCF38160.1 - 1.4e-08 34.3 0.0 3.4e-05 23.3 0.0 2.2 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase TauD PF02668.11 CCF38161.1 - 7.9e-50 169.9 1.7 1e-49 169.5 1.2 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.11 CCF38162.1 - 3.3e-30 104.9 26.2 4.4e-30 104.5 12.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF38162.1 - 1.4e-08 34.4 0.1 4.3e-08 32.8 0.1 1.9 1 0 0 1 1 1 1 MFS_1 like family Fungal_trans_2 PF11951.3 CCF38163.1 - 1.5e-10 40.2 0.1 6.4e-10 38.1 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF605 PF04652.11 CCF38163.1 - 0.25 10.7 5.9 0.33 10.2 4.1 1.2 1 0 0 1 1 1 0 Vta1 like Rax2 PF12768.2 CCF38164.1 - 3.5e-86 288.8 2.3 7.3e-81 271.4 0.0 3.4 3 1 0 3 3 3 2 Cortical protein marker for cell polarity Kelch_4 PF13418.1 CCF38164.1 - 0.054 13.2 1.3 0.87 9.4 0.1 3.4 3 0 0 3 3 3 0 Galactose oxidase, central domain HLH PF00010.21 CCF38168.1 - 4.6e-13 48.6 1.1 1.5e-12 47.0 0.7 1.9 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HALZ PF02183.13 CCF38168.1 - 0.0045 16.6 0.5 0.009 15.7 0.3 1.5 1 0 0 1 1 1 1 Homeobox associated leucine zipper DUF972 PF06156.8 CCF38168.1 - 0.86 9.9 2.8 2.7 8.3 1.7 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Rootletin PF15035.1 CCF38168.1 - 4.7 7.1 15.3 20 5.1 10.6 2.1 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion RRM_1 PF00076.17 CCF38170.1 - 2.3e-14 52.7 0.1 5.6e-14 51.5 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF38170.1 - 3.3e-14 52.6 0.0 5.9e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF38170.1 - 2.3e-09 36.9 0.0 4.3e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_M43 PF05572.8 CCF38171.1 - 9.5e-18 64.2 0.0 2.4e-17 62.9 0.0 1.6 2 0 0 2 2 2 1 Pregnancy-associated plasma protein-A Reprolysin_2 PF13574.1 CCF38171.1 - 0.00075 19.5 0.0 0.0011 19.0 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.1 CCF38171.1 - 0.013 15.9 0.0 0.023 15.2 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 CCF38171.1 - 0.024 14.5 0.0 0.033 14.1 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 NAD_binding_8 PF13450.1 CCF38174.1 - 2.1e-09 37.2 0.0 2.4e-09 37.0 0.0 1.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 CCF38174.1 - 1.6e-07 31.1 0.0 1.8e-07 31.0 0.0 1.0 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 CCF38174.1 - 1.8e-05 24.8 0.0 2e-05 24.7 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 CCF38174.1 - 0.00025 20.2 0.1 0.00028 20.1 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase HI0933_like PF03486.9 CCF38174.1 - 0.00029 19.4 0.1 0.00032 19.3 0.1 1.0 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.9 CCF38174.1 - 0.00056 19.8 0.0 0.00056 19.8 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF38174.1 - 0.00064 18.8 0.1 0.00066 18.8 0.0 1.0 1 0 0 1 1 1 1 Thi4 family DAO PF01266.19 CCF38174.1 - 0.00065 18.7 0.3 0.00071 18.5 0.2 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 CCF38174.1 - 0.00099 18.2 0.0 0.00099 18.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 CCF38174.1 - 0.019 14.0 0.4 0.02 13.9 0.3 1.0 1 0 0 1 1 1 0 FAD dependent oxidoreductase ThiF PF00899.16 CCF38174.1 - 0.027 14.2 0.0 0.03 14.1 0.0 1.1 1 0 0 1 1 1 0 ThiF family Pyr_redox PF00070.22 CCF38174.1 - 0.051 13.9 0.1 0.058 13.8 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF38174.1 - 0.072 11.7 0.1 0.075 11.6 0.0 1.0 1 0 0 1 1 1 0 Tryptophan halogenase FAD_binding_2 PF00890.19 CCF38174.1 - 0.13 11.0 0.3 0.13 11.0 0.2 1.0 1 0 0 1 1 1 0 FAD binding domain FMO-like PF00743.14 CCF38174.1 - 0.15 10.2 0.0 0.15 10.2 0.0 1.0 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like MFS_1 PF07690.11 CCF38175.1 - 6.1e-35 120.5 29.6 5.7e-34 117.3 21.5 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.11 CCF38176.1 - 4.4e-46 157.2 37.0 7.5e-46 156.4 25.7 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF38176.1 - 4.9e-14 51.7 14.4 1.1e-13 50.6 10.0 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter SMN PF06003.7 CCF38176.1 - 0.081 12.0 1.8 0.12 11.4 0.8 1.5 1 1 1 2 2 2 0 Survival motor neuron protein (SMN) Transglut_core PF01841.14 CCF38177.1 - 2.4e-08 34.1 0.0 5.1e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily NTP_transf_3 PF12804.2 CCF38178.1 - 0.0015 18.5 0.0 0.0023 18.0 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF2205 PF10224.4 CCF38179.1 - 0.012 15.1 0.4 0.014 14.9 0.3 1.1 1 0 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) CENP-F_leu_zip PF10473.4 CCF38179.1 - 0.014 15.2 2.1 0.018 14.9 1.5 1.1 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Rootletin PF15035.1 CCF38179.1 - 0.025 14.5 1.2 0.029 14.3 0.8 1.1 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Filament PF00038.16 CCF38179.1 - 0.054 12.9 0.8 0.058 12.8 0.5 1.0 1 0 0 1 1 1 0 Intermediate filament protein TMF_DNA_bd PF12329.3 CCF38179.1 - 0.06 13.1 0.7 0.077 12.8 0.2 1.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding HALZ PF02183.13 CCF38179.1 - 0.07 12.8 1.0 5.8 6.7 0.1 2.2 1 1 1 2 2 2 0 Homeobox associated leucine zipper HAP1_N PF04849.8 CCF38179.1 - 0.21 10.4 2.4 0.24 10.3 1.6 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region BIR PF00653.16 CCF38180.1 - 1.2e-12 48.0 0.1 1.9e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain Peptidase_S8 PF00082.17 CCF38181.1 - 2.6e-41 141.6 4.8 4e-41 141.0 3.4 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 CCF38181.1 - 8.7e-12 45.4 0.0 4.5e-11 43.1 0.0 2.1 2 0 0 2 2 2 1 Peptidase inhibitor I9 Zn_clus PF00172.13 CCF38182.1 - 9.6e-08 31.8 7.4 1.6e-07 31.1 5.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3439 PF11921.3 CCF38182.1 - 0.0072 16.0 7.3 0.014 15.1 5.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) Dicty_REP PF05086.7 CCF38182.1 - 0.72 7.5 2.0 0.9 7.2 1.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Mucin PF01456.12 CCF38182.1 - 1.3 8.7 13.5 3 7.6 9.4 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein AA_permease PF00324.16 CCF38183.1 - 8.5e-136 453.0 35.8 9.6e-136 452.8 24.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF38183.1 - 8.8e-39 133.2 39.1 1.1e-38 132.9 27.1 1.0 1 0 0 1 1 1 1 Amino acid permease Defensin_big PF14862.1 CCF38183.1 - 0.051 13.6 0.2 0.16 12.0 0.1 1.8 1 0 0 1 1 1 0 Big defensin Methyltransf_23 PF13489.1 CCF38186.1 - 3.2e-19 69.2 0.0 1.1e-18 67.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF38186.1 - 5.3e-12 46.3 0.0 2e-11 44.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF38186.1 - 5.9e-12 45.4 0.0 2.1e-11 43.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF38186.1 - 6.2e-08 33.0 0.0 1.2e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF38186.1 - 1.4e-06 28.6 0.0 5.8e-06 26.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF38186.1 - 0.0022 18.3 0.0 0.0055 17.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 CCF38186.1 - 0.0031 17.0 0.0 0.0048 16.3 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 CCF38186.1 - 0.0042 16.4 0.0 0.024 13.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 CCF38186.1 - 0.021 14.8 0.0 0.064 13.2 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain PrmA PF06325.8 CCF38186.1 - 0.045 12.8 0.0 0.064 12.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.12 CCF38186.1 - 0.058 12.4 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase CMAS PF02353.15 CCF38186.1 - 0.084 11.9 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase FtsJ PF01728.14 CCF38186.1 - 0.18 11.8 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Cu-oxidase_2 PF07731.9 CCF38187.1 - 4.4e-22 78.0 0.6 6.4e-22 77.5 0.4 1.2 1 0 0 1 1 1 1 Multicopper oxidase Fungal_trans PF04082.13 CCF38188.1 - 2.6e-15 56.0 0.2 4.3e-15 55.2 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF38188.1 - 0.0027 17.5 5.2 0.0047 16.8 3.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pyr_redox_2 PF07992.9 CCF38190.1 - 1.5e-12 47.8 0.0 7.7e-12 45.5 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF38190.1 - 2.6e-11 43.7 0.7 1.6e-08 34.7 0.0 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF38190.1 - 6.4e-11 42.7 0.1 1.5e-06 28.3 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF38190.1 - 8.6e-11 41.3 3.5 0.001 18.0 0.0 4.1 4 0 0 4 4 4 4 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 CCF38190.1 - 3e-05 23.8 2.0 0.1 12.3 0.0 3.5 3 1 1 4 4 4 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 CCF38190.1 - 0.018 15.0 0.1 5.7 7.0 0.0 2.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.9 CCF38190.1 - 0.034 12.7 1.3 14 4.1 0.0 3.0 2 1 1 3 3 3 0 Tryptophan halogenase K_oxygenase PF13434.1 CCF38190.1 - 0.11 11.3 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.9 CCF38190.1 - 0.24 9.7 0.7 14 3.9 0.0 3.0 4 0 0 4 4 4 0 HI0933-like protein Fungal_trans PF04082.13 CCF38191.1 - 6.3e-14 51.4 0.0 2.3e-13 49.6 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF38191.1 - 0.0014 18.4 4.6 0.0033 17.3 3.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Herpes_UL32 PF06070.6 CCF38191.1 - 0.037 12.4 1.6 0.053 11.9 1.1 1.1 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 Grp1_Fun34_YaaH PF01184.14 CCF38192.1 - 2.9e-28 98.5 24.6 3.9e-28 98.2 17.0 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family BTB PF00651.26 CCF38193.1 - 4.1e-09 36.3 0.0 4.5e-07 29.8 0.0 2.3 2 0 0 2 2 2 2 BTB/POZ domain Cutinase PF01083.17 CCF38194.1 - 8.3e-32 110.3 0.2 1.3e-31 109.7 0.2 1.3 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.6 CCF38194.1 - 0.0012 18.2 0.0 0.0021 17.5 0.0 1.3 1 0 0 1 1 1 1 PE-PPE domain VirJ PF06057.6 CCF38194.1 - 0.069 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Abhydrolase_2 PF02230.11 CCF38194.1 - 0.14 11.6 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase BIR PF00653.16 CCF38196.1 - 8.4e-43 144.6 2.1 1.8e-20 73.0 0.0 2.5 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain HRXXH PF13933.1 CCF38197.1 - 9.5e-106 352.7 0.1 1.2e-105 352.4 0.1 1.1 1 0 0 1 1 1 1 Putative peptidase family HCV_NS5a_1a PF08300.8 CCF38197.1 - 0.023 14.5 0.7 0.23 11.3 0.2 2.4 2 0 0 2 2 2 0 Hepatitis C virus non-structural 5a zinc finger domain MFS_1 PF07690.11 CCF38198.1 - 5.2e-39 133.9 45.8 1.8e-38 132.1 31.6 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF38198.1 - 8.3e-14 51.0 11.1 8.3e-14 51.0 7.7 2.8 2 1 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.8 CCF38198.1 - 0.00067 17.9 21.4 0.0016 16.7 14.8 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PgaD PF13994.1 CCF38198.1 - 0.52 9.7 3.3 0.49 9.8 0.2 2.4 1 1 1 2 2 2 0 PgaD-like protein Steroid_dh PF02544.11 CCF38199.1 - 2.2e-14 53.5 0.7 2.4e-14 53.3 0.5 1.1 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.7 CCF38199.1 - 0.027 13.7 2.4 0.035 13.4 1.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) MFS_1 PF07690.11 CCF38200.1 - 5.8e-26 91.0 26.1 1.3e-25 89.8 17.3 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily SPC12 PF06645.8 CCF38200.1 - 0.078 12.7 3.4 0.82 9.5 0.1 2.9 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) p450 PF00067.17 CCF38201.1 - 3e-51 174.4 0.0 4e-51 173.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cu-oxidase_2 PF07731.9 CCF38202.1 - 8.5e-20 70.6 2.3 2.8e-19 68.9 0.8 2.1 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.17 CCF38202.1 - 5e-15 55.7 0.1 8.7e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 Multicopper oxidase Glyco_transf_5 PF08323.6 CCF38203.1 - 2.2e-15 56.8 0.1 5.1e-15 55.6 0.1 1.6 1 0 0 1 1 1 1 Starch synthase catalytic domain Alpha-amylase PF00128.19 CCF38203.1 - 6.6e-15 55.3 5.9 2.4e-14 53.4 1.2 3.4 2 1 0 2 2 2 1 Alpha amylase, catalytic domain DUF1656 PF07869.7 CCF38204.1 - 0.0048 16.6 1.9 0.012 15.3 1.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1656) DUF3028 PF11229.3 CCF38204.1 - 0.087 11.0 0.1 0.11 10.7 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3028) p450 PF00067.17 CCF38205.1 - 1.2e-58 198.8 0.0 2.1e-58 197.9 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 CFEM PF05730.6 CCF38206.1 - 3.9e-12 45.8 11.1 6.2e-12 45.1 7.7 1.3 1 0 0 1 1 1 1 CFEM domain Peptidase_C34 PF05413.6 CCF38206.1 - 0.6 10.1 2.2 13 5.8 0.4 2.1 1 1 1 2 2 2 0 Putative closterovirus papain-like endopeptidase Annexin PF00191.15 CCF38207.1 - 8.6e-18 64.0 0.3 5.2e-05 23.0 0.0 4.4 4 0 0 4 4 4 4 Annexin UPF0506 PF11703.3 CCF38209.1 - 0.03 14.2 0.6 0.034 14.0 0.4 1.3 1 1 0 1 1 1 0 UPF0506 adh_short PF00106.20 CCF38210.1 - 9.8e-28 97.1 0.4 3.5e-27 95.3 0.3 1.8 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF38210.1 - 2.1e-14 53.5 0.0 3.2e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF38210.1 - 9e-11 41.9 0.0 1.2e-10 41.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 CCF38210.1 - 1.4e-10 41.0 0.0 1.8e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF38210.1 - 1e-06 28.9 0.0 2.2e-06 27.7 0.0 1.6 1 1 0 1 1 1 1 NADH(P)-binding F420_oxidored PF03807.12 CCF38210.1 - 0.0014 19.0 0.0 0.0063 16.9 0.0 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Enoyl_reductase PF12241.3 CCF38210.1 - 0.0091 15.0 0.0 0.015 14.3 0.0 1.3 1 0 0 1 1 1 1 Trans-2-enoyl-CoA reductase catalytic region Polysacc_synt_2 PF02719.10 CCF38210.1 - 0.022 13.6 0.0 0.069 12.0 0.0 1.7 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 CCF38210.1 - 0.044 12.4 0.0 0.088 11.4 0.0 1.5 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family GST_N_3 PF13417.1 CCF38212.1 - 9.7e-10 38.5 0.0 1.7e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 CCF38212.1 - 1.6e-08 34.3 0.1 3.2e-08 33.3 0.1 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 CCF38212.1 - 3.1e-06 27.0 0.0 5e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 CCF38212.1 - 0.00025 21.4 0.0 0.00071 20.0 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 CCF38212.1 - 0.0018 18.2 0.1 0.0033 17.3 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain SCAN PF02023.12 CCF38212.1 - 0.036 13.5 0.1 0.085 12.3 0.0 1.5 1 0 0 1 1 1 0 SCAN domain RTA1 PF04479.8 CCF38213.1 - 3e-42 144.6 2.7 3.7e-42 144.3 1.9 1.1 1 0 0 1 1 1 1 RTA1 like protein Lipase_GDSL_2 PF13472.1 CCF38214.1 - 2.3e-10 40.9 0.0 3.8e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 CCF38214.1 - 6.2e-08 32.7 0.0 1.3e-07 31.7 0.0 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Sugar_tr PF00083.19 CCF38215.1 - 4.8e-110 368.2 26.4 7.3e-110 367.6 18.3 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF38215.1 - 2.4e-24 85.7 36.2 7.1e-18 64.4 9.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Lysis_S PF04971.7 CCF38215.1 - 0.056 13.1 2.8 0.07 12.8 0.4 2.4 2 0 0 2 2 2 0 Lysis protein S ECH PF00378.15 CCF38216.1 - 3.9e-22 78.5 0.2 7.6e-19 67.8 0.1 2.2 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase family SERTA PF06031.8 CCF38217.1 - 0.12 11.6 0.1 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 SERTA motif Pkinase PF00069.20 CCF38218.1 - 8.8e-59 198.7 0.0 1.2e-58 198.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF38218.1 - 5e-22 78.2 0.0 8.4e-22 77.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF38218.1 - 2.9e-07 29.7 0.0 4.7e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CCF38218.1 - 0.00015 21.6 0.3 0.0013 18.5 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 CCF38218.1 - 0.0013 17.8 0.0 0.0022 17.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 CCF38218.1 - 0.01 15.1 0.2 0.023 14.0 0.1 1.6 1 1 0 1 1 1 0 RIO1 family Pyr_redox_3 PF13738.1 CCF38219.1 - 3.5e-18 66.3 0.0 4.9e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 CCF38219.1 - 4.7e-11 41.5 0.0 6.1e-11 41.2 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.1 CCF38219.1 - 5.6e-11 41.9 0.0 1e-09 37.8 0.0 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 CCF38219.1 - 1.5e-06 28.2 0.0 2.1e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF38219.1 - 3.8e-06 26.8 0.1 5e-05 23.2 0.0 2.5 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 CCF38219.1 - 0.0011 18.7 0.1 0.033 13.9 0.0 2.4 1 1 0 1 1 1 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.7 CCF38219.1 - 0.02 13.8 0.0 0.081 11.8 0.0 1.8 1 1 0 1 1 1 0 Lycopene cyclase protein Chor_lyase PF04345.8 CCF38219.1 - 0.11 11.8 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Chorismate lyase DUF4064 PF13273.1 CCF38220.1 - 0.5 10.4 0.0 0.5 10.4 0.0 3.0 3 2 1 4 4 4 0 Protein of unknown function (DUF4064) ThiF PF00899.16 CCF38221.1 - 8.6e-16 57.9 0.1 1.6e-15 57.1 0.1 1.4 1 0 0 1 1 1 1 ThiF family Oxidored_FMN PF00724.15 CCF38223.1 - 2e-72 244.0 0.0 5.6e-69 232.7 0.0 2.1 1 1 1 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.12 CCF38223.1 - 0.024 13.4 0.5 0.13 11.0 0.0 2.0 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) Meth_synt_2 PF01717.13 CCF38224.1 - 1.6e-135 451.2 0.0 1.9e-135 451.0 0.0 1.0 1 0 0 1 1 1 1 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.7 CCF38224.1 - 4.4e-12 45.9 0.0 5.2e-08 32.5 0.0 2.1 2 0 0 2 2 2 2 Cobalamin-independent synthase, N-terminal domain DUF3018 PF11455.3 CCF38224.1 - 0.042 13.7 0.1 0.16 11.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3018) DUF4608 PF15381.1 CCF38225.1 - 0.16 12.0 1.0 0.26 11.4 0.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4608) Zn_clus PF00172.13 CCF38226.1 - 0.00092 19.0 7.4 0.0014 18.5 5.2 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-U1 PF06220.7 CCF38227.1 - 3.7e-07 29.5 0.2 5.8e-07 28.9 0.1 1.3 1 0 0 1 1 1 1 U1 zinc finger PIR PF00399.14 CCF38228.1 - 0.031 13.6 6.7 1.2 8.5 1.6 3.4 2 0 0 2 2 2 0 Yeast PIR protein repeat FAD-oxidase_C PF02913.14 CCF38229.1 - 4.3e-10 39.3 0.0 4.9e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain adh_short PF00106.20 CCF38230.1 - 2.5e-26 92.5 1.8 9e-26 90.7 1.2 1.7 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF38230.1 - 1.8e-11 44.0 0.1 2.6e-11 43.5 0.1 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF38230.1 - 7.9e-11 42.1 0.0 1e-10 41.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 CCF38230.1 - 6.9e-08 32.2 0.0 8.4e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF38230.1 - 1.5e-06 28.3 0.1 3.3e-06 27.2 0.1 1.5 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 CCF38230.1 - 0.00021 20.3 0.0 0.00029 19.8 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.10 CCF38230.1 - 0.0039 16.1 0.0 0.0055 15.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 CCF38230.1 - 0.028 13.1 0.0 0.037 12.7 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_trans_1_4 PF13692.1 CCF38230.1 - 0.054 13.6 0.0 0.17 12.0 0.0 1.7 1 1 0 1 1 1 0 Glycosyl transferases group 1 MTS PF05175.9 CCF38230.1 - 0.055 12.8 0.0 2.6 7.3 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase small domain EPL1 PF10513.4 CCF38231.1 - 6e-32 111.1 4.0 6e-32 111.1 2.7 3.9 3 1 0 3 3 3 2 Enhancer of polycomb-like ASL_C2 PF14698.1 CCF38233.1 - 7.1e-19 67.6 0.0 1.5e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Lyase_1 PF00206.15 CCF38233.1 - 1.4e-14 54.0 0.0 2e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Lyase DUF4108 PF13390.1 CCF38233.1 - 0.0027 17.4 0.0 0.0038 16.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4108) Rtt106 PF08512.7 CCF38234.1 - 1.6e-24 85.7 0.0 3.6e-24 84.5 0.0 1.6 1 0 0 1 1 1 1 Histone chaperone Rttp106-like Rad52_Rad22 PF04098.10 CCF38236.1 - 2.7e-62 209.0 0.0 4e-62 208.5 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein DnaJ PF00226.26 CCF38237.1 - 2.5e-15 55.9 2.1 3.3e-15 55.5 1.5 1.2 1 0 0 1 1 1 1 DnaJ domain FA_desaturase PF00487.19 CCF38238.1 - 1.5e-16 60.5 15.6 1.5e-16 60.5 10.8 2.1 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.23 CCF38238.1 - 0.023 14.4 0.0 0.048 13.4 0.0 1.6 1 0 0 1 1 1 0 Cytochrome b5-like Heme/Steroid binding domain Ctr PF04145.10 CCF38238.1 - 0.059 13.4 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 Ctr copper transporter family NADH-u_ox-rdase PF10785.4 CCF38238.1 - 0.1 12.8 0.5 1.2 9.3 0.2 2.7 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit COesterase PF00135.23 CCF38239.1 - 6.8e-80 269.2 0.0 1.4e-73 248.4 0.0 2.0 2 0 0 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF38239.1 - 9.1e-07 28.6 0.1 3.2e-06 26.8 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_M13 PF01431.16 CCF38240.1 - 1.3e-53 181.2 0.0 2.2e-53 180.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13_N PF05649.8 CCF38240.1 - 9.7e-53 179.6 0.0 1.3e-52 179.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peroxidase_2 PF01328.12 CCF38241.1 - 6.6e-44 149.8 0.2 7.6e-44 149.6 0.1 1.0 1 0 0 1 1 1 1 Peroxidase, family 2 FA_hydroxylase PF04116.8 CCF38242.1 - 2.7e-14 53.5 8.5 2.7e-14 53.5 5.9 2.4 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily Nuc_H_symport PF03825.11 CCF38243.1 - 0.0039 16.0 0.1 0.0046 15.7 0.1 1.0 1 0 0 1 1 1 1 Nucleoside H+ symporter EIIC-GAT PF03611.9 CCF38244.1 - 0.12 11.1 2.8 0.048 12.4 0.3 1.5 2 0 0 2 2 2 0 PTS system sugar-specific permease component DUF3176 PF11374.3 CCF38244.1 - 0.12 12.2 3.5 0.2 11.5 2.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3176) LANC_like PF05147.8 CCF38245.1 - 1.7e-22 79.4 0.0 7.1e-22 77.4 0.0 1.8 1 1 0 1 1 1 1 Lanthionine synthetase C-like protein Chitin_bind_1 PF00187.14 CCF38246.1 - 6.7e-15 54.7 44.4 2.6e-08 33.7 14.7 2.4 2 0 0 2 2 2 2 Chitin recognition protein 4HBT_3 PF13622.1 CCF38247.1 - 3.2e-44 151.6 0.0 3.8e-44 151.3 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.10 CCF38247.1 - 0.012 15.2 0.0 0.02 14.5 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA thioesterase Aa_trans PF01490.13 CCF38248.1 - 3.4e-43 147.6 31.7 3.9e-43 147.4 22.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein MFS_1 PF07690.11 CCF38250.1 - 6.3e-49 166.5 19.4 1.3e-48 165.5 13.5 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF38250.1 - 1.2e-08 33.9 11.5 1.2e-08 33.9 8.0 2.1 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_3 PF05977.8 CCF38250.1 - 8.9e-05 20.7 4.3 8.9e-05 20.7 3.0 2.1 3 0 0 3 3 3 1 Transmembrane secretion effector TRI12 PF06609.8 CCF38250.1 - 0.00033 18.9 4.7 0.00053 18.3 3.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.15 CCF38250.1 - 0.022 12.8 2.5 0.045 11.8 1.5 1.6 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family PepSY_TM_2 PF13703.1 CCF38250.1 - 0.067 13.3 2.1 0.35 11.0 0.0 3.1 2 0 0 2 2 2 0 PepSY-associated TM helix Syntaxin-18_N PF10496.4 CCF38251.1 - 2e-17 62.8 0.1 4.4e-17 61.6 0.0 1.6 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus Nexin_C PF08628.7 CCF38251.1 - 0.053 13.6 0.1 0.067 13.2 0.1 1.1 1 0 0 1 1 1 0 Sorting nexin C terminal PLU-1 PF08429.6 CCF38251.1 - 0.065 12.1 0.2 0.079 11.8 0.1 1.4 1 1 0 1 1 1 0 PLU-1-like protein HR1 PF02185.11 CCF38251.1 - 0.071 12.8 0.7 1.2 8.8 0.1 2.2 2 0 0 2 2 2 0 Hr1 repeat CorA PF01544.13 CCF38251.1 - 0.18 10.8 1.4 0.53 9.2 0.0 1.8 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein CH PF00307.26 CCF38252.1 - 5.5e-08 32.8 1.0 6.5e-08 32.5 0.7 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain DEAD PF00270.24 CCF38253.1 - 2.2e-44 150.9 0.1 4.8e-44 149.8 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF38253.1 - 2.2e-25 88.3 0.1 6.3e-25 86.8 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF1253 PF06862.7 CCF38253.1 - 6.6e-06 24.7 0.5 3.9e-05 22.2 0.0 2.4 1 1 2 3 3 3 1 Protein of unknown function (DUF1253) AAA_19 PF13245.1 CCF38253.1 - 0.044 13.5 0.4 0.14 11.8 0.3 1.8 1 0 0 1 1 1 0 Part of AAA domain WSK PF03832.8 CCF38253.1 - 0.056 12.7 13.4 0.81 9.0 3.9 3.0 2 0 0 2 2 2 0 WSK motif Cys_Met_Meta_PP PF01053.15 CCF38254.1 - 1.4e-10 40.0 0.0 7.5e-10 37.6 0.0 1.8 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Terpene_synth_C PF03936.11 CCF38255.1 - 7.4e-11 41.7 0.2 7e-10 38.5 0.2 2.0 1 1 0 1 1 1 1 Terpene synthase family, metal binding domain ANTAR PF03861.9 CCF38255.1 - 0.043 13.3 0.0 0.11 12.1 0.0 1.7 1 0 0 1 1 1 0 ANTAR domain zf-U1 PF06220.7 CCF38255.1 - 0.16 11.5 1.8 4.1 7.0 0.3 2.7 3 0 0 3 3 3 0 U1 zinc finger Polysacc_deac_1 PF01522.16 CCF38256.1 - 1.5e-05 24.6 0.0 2.9e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase DNA_pol_B_thumb PF14791.1 CCF38256.1 - 0.016 14.8 0.1 0.49 10.1 0.0 2.3 2 0 0 2 2 2 0 DNA polymerase beta thumb Polysacc_deac_2 PF04748.8 CCF38256.1 - 0.021 13.8 0.0 0.033 13.1 0.0 1.4 1 1 0 1 1 1 0 Divergent polysaccharide deacetylase MRP-L28 PF09812.4 CCF38257.1 - 5e-05 23.1 0.3 7.3e-05 22.6 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 DUF4202 PF13875.1 CCF38257.1 - 0.05 13.2 1.0 0.062 12.9 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4202) DUF4202 PF13875.1 CCF38260.1 - 1.8e-08 34.2 0.0 2e-08 34.1 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4202) Sigma70_r4_2 PF08281.7 CCF38260.1 - 0.07 12.6 0.0 0.18 11.3 0.0 1.6 2 0 0 2 2 2 0 Sigma-70, region 4 TPR_2 PF07719.12 CCF38260.1 - 0.13 12.2 0.1 0.2 11.6 0.1 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat Myb_DNA-bind_6 PF13921.1 CCF38261.1 - 1.7e-05 24.8 0.1 0.0004 20.4 0.0 2.6 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 CCF38261.1 - 0.0037 17.2 0.0 0.0084 16.1 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Dicty_REP PF05086.7 CCF38263.1 - 6.9 4.2 6.4 8.4 3.9 4.4 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Glyco_hydro_35 PF01301.14 CCF38264.1 - 1.1e-57 195.8 0.1 1.2e-57 195.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Cellulase PF00150.13 CCF38264.1 - 2.7e-06 26.7 0.0 4e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.10 CCF38264.1 - 3.2e-06 26.5 0.2 1.3e-05 24.5 0.1 1.8 1 1 0 1 1 1 1 Beta-galactosidase AF1Q PF15017.1 CCF38264.1 - 0.0033 17.3 0.0 0.0058 16.5 0.0 1.4 1 0 0 1 1 1 1 Drug resistance and apoptosis regulator SH2_2 PF14633.1 CCF38265.1 - 3.5e-77 258.3 0.0 7.5e-77 257.3 0.0 1.6 1 0 0 1 1 1 1 SH2 domain DLD PF14878.1 CCF38265.1 - 1.7e-37 128.0 3.0 1.7e-37 128.0 2.1 4.3 4 0 0 4 4 4 1 Death-like domain of SPT6 HHH_7 PF14635.1 CCF38265.1 - 3.2e-30 104.3 0.0 6.6e-30 103.2 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.1 CCF38265.1 - 1.6e-29 102.4 0.0 1.5e-28 99.3 0.0 2.5 2 0 0 2 2 2 1 Holliday-junction resolvase-like of SPT6 HTH_44 PF14641.1 CCF38265.1 - 9.1e-18 64.4 1.5 1e-16 61.0 1.1 2.4 1 1 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.1 CCF38265.1 - 7.2e-07 29.2 6.1 7.2e-07 29.2 4.2 6.3 4 1 3 7 7 7 1 Acidic N-terminal SPT6 SH2 PF00017.19 CCF38265.1 - 0.00033 20.4 0.0 0.00087 19.0 0.0 1.8 1 0 0 1 1 1 1 SH2 domain HHH_3 PF12836.2 CCF38265.1 - 0.0039 17.1 0.0 0.013 15.4 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif Exo_endo_phos_2 PF14529.1 CCF38266.1 - 1.3e-17 63.4 0.0 4.9e-17 61.6 0.0 2.0 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 CCF38266.1 - 1e-14 55.1 0.0 1.7e-14 54.3 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.7 CCF38266.1 - 3.7e-05 23.5 1.6 9.5e-05 22.2 1.1 1.7 1 0 0 1 1 1 1 GRF zinc finger CART PF06373.6 CCF38266.1 - 0.057 13.3 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 Cocaine and amphetamine regulated transcript protein (CART) HMG_box PF00505.14 CCF38267.1 - 5.1e-22 77.9 1.1 7.7e-22 77.3 0.7 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 CCF38267.1 - 1.1e-07 32.1 0.2 1.8e-07 31.4 0.2 1.3 1 0 0 1 1 1 1 HMG-box domain BCL9 PF11502.3 CCF38268.1 - 0.15 11.5 3.5 0.43 10.1 2.4 1.8 1 0 0 1 1 1 0 B-cell lymphoma 9 protein APG6 PF04111.7 CCF38268.1 - 0.41 9.6 3.1 1 8.3 2.2 1.6 1 0 0 1 1 1 0 Autophagy protein Apg6 Hemerythrin PF01814.18 CCF38268.1 - 1.2 9.3 10.7 0.95 9.6 1.5 3.2 2 1 0 2 2 2 0 Hemerythrin HHE cation binding domain FUSC PF04632.7 CCF38268.1 - 6.8 4.9 8.4 2 6.7 0.8 2.3 2 0 0 2 2 2 0 Fusaric acid resistance protein family WD40 PF00400.27 CCF38269.1 - 6.1e-20 70.2 7.3 5.1e-07 29.3 0.0 5.1 4 0 0 4 4 4 4 WD domain, G-beta repeat ADH_zinc_N PF00107.21 CCF38270.1 - 6e-27 93.7 0.1 9.1e-27 93.1 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF38270.1 - 6.8e-08 32.2 0.0 3.5e-07 29.9 0.0 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 CCF38270.1 - 4e-06 27.7 0.0 0.00057 20.7 0.0 2.4 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ACP_syn_III_C PF08541.5 CCF38270.1 - 0.14 12.2 0.6 0.38 10.8 0.4 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Spt5-NGN PF03439.8 CCF38271.1 - 4.7e-25 87.1 0.1 8.6e-25 86.3 0.0 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.3 CCF38271.1 - 1.2e-19 70.7 10.5 1.2e-19 70.7 7.3 4.5 3 1 0 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.24 CCF38271.1 - 0.00011 21.7 0.5 0.00011 21.7 0.4 4.5 4 0 0 4 4 4 1 KOW motif Glyco_trans_2_3 PF13632.1 CCF38272.1 - 2.3e-47 161.2 4.0 2.3e-47 161.2 2.8 1.7 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 CCF38272.1 - 8.9e-08 32.1 0.1 1.3e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 CCF38272.1 - 4.2e-07 29.7 0.0 8.3e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 CCF38272.1 - 0.00026 20.3 0.1 0.00073 18.8 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 21 CLTH PF10607.4 CCF38273.1 - 2.5e-35 121.2 0.0 4.2e-35 120.5 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.6 CCF38273.1 - 0.0024 17.5 0.1 0.0062 16.2 0.1 1.8 1 0 0 1 1 1 1 LisH Transket_pyr PF02779.19 CCF38274.1 - 2.6e-42 144.3 0.0 4.1e-42 143.6 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 CCF38274.1 - 2.4e-32 111.4 0.1 6.8e-32 110.0 0.0 1.8 2 0 0 2 2 2 1 Transketolase, C-terminal domain F-actin_cap_A PF01267.12 CCF38275.1 - 3e-96 321.6 0.0 3.4e-96 321.4 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit Amidohydro_1 PF01979.15 CCF38276.1 - 4.3e-37 128.5 0.4 5.2e-37 128.2 0.2 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 CCF38276.1 - 5.6e-16 59.3 0.0 3.1e-14 53.6 0.0 2.6 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 CCF38276.1 - 4.9e-13 49.0 1.5 7e-11 41.9 0.1 2.7 1 1 1 2 2 2 2 Amidohydrolase family Amidohydro_5 PF13594.1 CCF38276.1 - 5e-13 48.6 0.0 2.4e-12 46.4 0.0 2.3 1 0 0 1 1 1 1 Amidohydrolase DUF1640 PF07798.6 CCF38278.1 - 2.6e-66 223.0 8.3 3e-66 222.8 5.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Lzipper-MIP1 PF14389.1 CCF38278.1 - 0.012 15.6 3.4 2.7 8.1 0.0 2.5 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Metal_resist PF13801.1 CCF38278.1 - 0.034 14.1 0.9 0.034 14.1 0.6 1.8 2 0 0 2 2 2 0 Heavy-metal resistance cwf21 PF08312.7 CCF38278.1 - 0.057 13.2 3.7 0.13 12.1 2.0 2.1 2 1 0 2 2 2 0 cwf21 domain Syntaxin PF00804.20 CCF38278.1 - 1.5 9.0 10.2 1.3 9.2 3.8 2.6 1 1 2 3 3 3 0 Syntaxin DUF1690 PF07956.6 CCF38278.1 - 4 7.4 10.8 2.8 7.9 3.0 2.6 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) Pkinase PF00069.20 CCF38280.1 - 2.4e-66 223.5 0.0 2.7e-65 220.1 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF38280.1 - 1.4e-27 96.3 0.0 8.4e-27 93.8 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 CCF38280.1 - 0.021 14.5 0.1 0.078 12.6 0.1 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 CCF38280.1 - 0.1 11.6 0.1 0.29 10.1 0.0 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WD40 PF00400.27 CCF38281.1 - 2.3e-20 71.6 8.8 1.1e-05 25.0 0.6 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat eIF2A PF08662.6 CCF38281.1 - 0.00025 20.8 0.1 0.0009 19.0 0.0 1.8 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.11 CCF38281.1 - 0.0028 16.0 0.0 0.0046 15.3 0.0 1.3 1 0 0 1 1 1 1 Cytochrome D1 heme domain IKI3 PF04762.7 CCF38281.1 - 0.0049 14.7 0.0 0.007 14.2 0.0 1.2 1 0 0 1 1 1 1 IKI3 family PD40 PF07676.7 CCF38281.1 - 0.0092 15.6 0.2 5.1 6.8 0.0 3.0 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Miro PF08477.8 CCF38283.1 - 2.7e-20 73.0 0.0 3.6e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Ras PF00071.17 CCF38283.1 - 3.3e-13 49.3 0.0 4.4e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.18 CCF38283.1 - 3.6e-05 23.6 0.0 4.9e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 CCF38283.1 - 0.0079 16.0 0.6 0.15 11.9 0.1 2.1 1 1 0 2 2 2 1 Dynamin family AAA_24 PF13479.1 CCF38283.1 - 0.01 15.4 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 CCF38283.1 - 0.014 15.5 0.0 0.023 14.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.22 CCF38283.1 - 0.019 14.4 0.0 3.2 7.1 0.0 2.1 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain MobB PF03205.9 CCF38283.1 - 0.04 13.6 0.1 0.072 12.7 0.1 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 CCF38283.1 - 0.051 13.5 0.0 0.079 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.17 CCF38283.1 - 0.055 13.6 0.0 0.098 12.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Septin PF00735.13 CCF38283.1 - 0.088 11.8 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Septin DUF258 PF03193.11 CCF38283.1 - 0.1 11.7 0.1 0.22 10.6 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AIG1 PF04548.11 CCF38283.1 - 0.16 11.0 0.2 0.24 10.4 0.1 1.2 1 0 0 1 1 1 0 AIG1 family Ribosomal_S4e PF00900.15 CCF38284.1 - 2e-31 107.4 1.2 4e-31 106.5 0.3 1.8 2 0 0 2 2 2 1 Ribosomal family S4e RS4NT PF08071.7 CCF38284.1 - 2.8e-18 65.4 3.0 6e-18 64.4 2.1 1.6 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.20 CCF38284.1 - 3.8e-05 23.0 0.0 7.1e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.24 CCF38284.1 - 4e-05 23.1 1.6 4e-05 23.1 1.1 2.9 3 0 0 3 3 3 1 KOW motif Myb_DNA-binding PF00249.26 CCF38285.1 - 5.7e-11 42.2 0.1 0.00015 21.7 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CCF38285.1 - 9.9e-10 38.3 0.0 0.0022 18.0 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CCF38287.1 - 0.014 15.5 0.0 0.039 14.0 0.0 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain Septin PF00735.13 CCF38288.1 - 1.1e-32 113.1 0.0 1.9e-11 43.4 0.0 3.2 3 0 0 3 3 3 3 Septin Miro PF08477.8 CCF38288.1 - 0.011 16.2 0.0 0.037 14.5 0.0 1.9 2 0 0 2 2 2 0 Miro-like protein AAA_23 PF13476.1 CCF38288.1 - 0.013 15.7 0.1 0.013 15.7 0.0 1.8 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.1 CCF38288.1 - 0.014 15.3 0.2 0.054 13.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_17 PF13207.1 CCF38288.1 - 0.03 15.1 0.4 0.12 13.1 0.1 2.3 2 1 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 CCF38288.1 - 0.03 13.7 0.0 0.058 12.8 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_24 PF13479.1 CCF38288.1 - 0.065 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 CCF38288.1 - 0.13 11.7 0.0 0.31 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.18 CCF38288.1 - 0.14 11.9 2.6 1.3 8.8 0.0 2.9 3 1 1 4 4 4 0 Dynamin family CDC45 PF02724.9 CCF38288.1 - 7.7 4.4 6.6 0.91 7.4 0.7 1.9 2 0 0 2 2 2 0 CDC45-like protein DUF1035 PF06281.7 CCF38289.1 - 0.12 12.2 0.1 0.19 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1035) DUF3681 PF12442.3 CCF38289.1 - 0.34 11.1 1.5 0.6 10.3 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3681) GrpB PF04229.9 CCF38290.1 - 2.1e-49 167.4 0.0 2.5e-49 167.1 0.0 1.0 1 0 0 1 1 1 1 GrpB protein FAD_binding_3 PF01494.14 CCF38291.1 - 1.4e-24 86.8 0.0 1.9e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.22 CCF38291.1 - 8.2e-09 35.7 0.5 9.3e-05 22.7 0.2 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF38291.1 - 8.6e-09 34.7 0.1 0.003 16.5 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF38291.1 - 0.0012 18.8 0.2 0.0029 17.5 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF38291.1 - 0.039 13.8 0.0 0.32 10.8 0.0 2.3 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF38291.1 - 0.041 12.3 0.1 2.7 6.3 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein RhgB_N PF09284.5 CCF38294.1 - 7.4e-107 356.3 6.5 1.3e-106 355.5 4.5 1.4 1 0 0 1 1 1 1 Rhamnogalacturonase B, N-terminal CBM-like PF14683.1 CCF38294.1 - 2.7e-60 202.8 0.0 7.8e-60 201.3 0.0 1.8 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.1 CCF38294.1 - 6e-19 67.9 2.9 1.4e-18 66.7 2.0 1.6 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.1 CCF38294.1 - 0.0035 17.3 6.0 0.0035 17.3 4.1 3.5 2 1 1 3 3 3 1 Carboxypeptidase regulatory-like domain Acylphosphatase PF00708.13 CCF38294.1 - 0.0043 17.1 0.0 0.02 14.9 0.0 2.0 2 0 0 2 2 2 1 Acylphosphatase DUF3823 PF12866.2 CCF38294.1 - 0.028 13.9 0.1 0.056 12.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3823) Kelch_2 PF07646.10 CCF38294.1 - 0.034 13.9 0.0 15 5.5 0.0 2.8 2 0 0 2 2 2 0 Kelch motif DUF2012 PF09430.5 CCF38294.1 - 0.038 13.8 0.0 0.084 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2012) zf-C2H2 PF00096.21 CCF38295.1 - 0.013 15.7 0.7 0.013 15.7 0.5 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF38295.1 - 0.02 15.1 7.4 0.032 14.5 0.2 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_6 PF13912.1 CCF38295.1 - 0.029 14.2 2.1 0.094 12.6 0.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.2 CCF38295.1 - 0.064 13.4 0.0 0.16 12.2 0.0 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Sugar_tr PF00083.19 CCF38296.1 - 1.1e-90 304.3 25.9 1.3e-90 304.1 18.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF38296.1 - 3.3e-26 91.8 56.4 2.5e-22 79.0 21.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF38296.1 - 0.0096 15.6 1.0 0.057 13.2 0.1 2.6 2 0 0 2 2 2 1 MFS_1 like family NmrA PF05368.8 CCF38297.1 - 1.3e-30 106.4 0.6 5e-30 104.4 0.4 1.7 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF38297.1 - 3.3e-11 43.5 0.1 6.7e-11 42.5 0.0 1.6 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF38297.1 - 3.4e-05 23.4 0.1 0.00052 19.5 0.0 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.19 CCF38297.1 - 0.00048 20.4 0.1 0.0016 18.7 0.0 1.9 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.14 CCF38297.1 - 0.0025 16.5 0.1 0.0039 15.9 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Saccharop_dh PF03435.13 CCF38297.1 - 0.0035 16.3 0.1 0.0056 15.7 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase Sugar_tr PF00083.19 CCF38298.1 - 7.2e-88 295.1 13.4 1.2e-87 294.4 9.3 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF38298.1 - 9.1e-30 103.5 32.1 9.8e-30 103.4 16.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF38298.1 - 1.3e-06 26.8 3.3 1.3e-06 26.8 2.3 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Asp_Glu_race PF01177.17 CCF38299.1 - 8.8e-18 64.9 0.0 1e-17 64.8 0.0 1.1 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase RasGEF PF00617.14 CCF38300.1 - 2.1e-53 180.8 0.0 4.6e-53 179.7 0.0 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 CCF38300.1 - 3.1e-18 65.7 0.0 1e-17 64.1 0.0 2.0 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_9 PF14604.1 CCF38300.1 - 5.7e-06 25.8 0.0 1e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 CCF38300.1 - 3.9e-05 22.9 0.0 7.8e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain 4HBT_3 PF13622.1 CCF38301.1 - 1.5e-45 155.9 0.7 1.7e-45 155.8 0.5 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily WSC PF01822.14 CCF38305.1 - 1.4e-28 98.6 22.5 2.1e-15 56.3 9.6 2.1 2 0 0 2 2 2 2 WSC domain RNB PF00773.14 CCF38306.1 - 2.3e-55 188.1 0.0 2.8e-55 187.8 0.0 1.0 1 0 0 1 1 1 1 RNB domain INCENP_ARK-bind PF03941.10 CCF38307.1 - 3.1e-16 58.9 0.1 3.1e-16 58.9 0.1 2.6 3 0 0 3 3 3 1 Inner centromere protein, ARK binding region 2OG-FeII_Oxy PF03171.15 CCF38308.1 - 1.3e-12 47.8 0.0 2.1e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 CCF38308.1 - 4.9e-09 36.7 0.0 8.8e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Hepcidin PF06446.7 CCF38309.1 - 0.037 14.4 4.5 0.045 14.1 3.1 1.2 1 0 0 1 1 1 0 Hepcidin ACC_epsilon PF13822.1 CCF38309.1 - 0.62 10.4 6.2 0.89 9.9 4.3 1.2 1 0 0 1 1 1 0 Acyl-CoA carboxylase epsilon subunit Orbi_VP6 PF01516.11 CCF38311.1 - 0.32 10.0 6.1 0.45 9.5 4.2 1.1 1 0 0 1 1 1 0 Orbivirus helicase VP6 Pkinase PF00069.20 CCF38312.1 - 7.3e-76 254.7 0.0 9.8e-76 254.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF38312.1 - 2.6e-37 128.3 0.0 3.9e-37 127.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase UBA_2 PF08587.6 CCF38312.1 - 6.6e-16 58.2 0.2 1.6e-15 56.9 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.1 CCF38312.1 - 1.2e-05 24.3 0.0 2.4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 CCF38312.1 - 0.00035 19.9 0.1 0.00064 19.1 0.0 1.4 1 0 0 1 1 1 1 RIO1 family YukC PF10140.4 CCF38312.1 - 0.0054 15.3 0.0 0.0089 14.6 0.0 1.3 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC APH PF01636.18 CCF38312.1 - 0.055 13.1 0.7 0.31 10.7 0.2 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family 4HBT PF03061.17 CCF38316.1 - 0.0027 17.8 0.0 0.0039 17.2 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily adh_short PF00106.20 CCF38317.1 - 4.9e-28 98.1 0.0 6.6e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF38317.1 - 1.3e-26 93.8 0.0 1.6e-26 93.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF38317.1 - 4.9e-11 42.6 0.0 6.4e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.5 CCF38317.1 - 0.022 13.8 0.0 0.029 13.5 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Eno-Rase_NADH_b PF12242.3 CCF38317.1 - 0.059 13.1 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase SnoaL_2 PF12680.2 CCF38318.1 - 0.011 16.1 0.0 0.019 15.3 0.0 1.4 1 0 0 1 1 1 0 SnoaL-like domain Ribosomal_L2_C PF03947.13 CCF38320.1 - 3.1e-38 130.5 3.7 4.7e-38 129.9 2.6 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 CCF38320.1 - 1e-14 54.2 0.1 2e-14 53.3 0.1 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain DNA_pol_B_palm PF14792.1 CCF38321.1 - 5.3e-34 116.6 0.0 1.1e-33 115.6 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.1 CCF38321.1 - 3.7e-23 80.9 0.0 7.3e-22 76.8 0.0 2.4 2 0 0 2 2 2 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.4 CCF38321.1 - 2.1e-20 71.9 0.0 5.5e-20 70.6 0.0 1.8 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.1 CCF38321.1 - 1.4e-16 60.3 0.1 3.5e-16 59.1 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_5 PF14520.1 CCF38321.1 - 0.00084 19.4 0.1 2.9 8.1 0.0 3.4 3 0 0 3 3 3 1 Helix-hairpin-helix domain HTH_3 PF01381.17 CCF38321.1 - 0.017 14.9 0.0 0.093 12.5 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix NTP_transf_2 PF01909.18 CCF38321.1 - 0.025 14.9 0.0 0.053 13.8 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase domain DUF4192 PF13830.1 CCF38321.1 - 0.16 11.5 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) CHDNT PF08073.7 CCF38321.1 - 0.18 11.5 0.0 27 4.5 0.0 2.4 2 0 0 2 2 2 0 CHDNT (NUC034) domain Methyltransf_2 PF00891.13 CCF38322.1 - 2.6e-32 111.9 0.0 3.9e-32 111.3 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_18 PF12847.2 CCF38322.1 - 5.1e-05 23.8 0.0 0.00016 22.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 CCF38322.1 - 0.00048 19.5 0.0 0.00074 18.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 CCF38322.1 - 0.0017 18.6 0.0 0.0036 17.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.13 CCF38322.1 - 0.0021 17.3 0.0 0.0033 16.7 0.0 1.2 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_12 PF08242.7 CCF38322.1 - 0.012 16.0 0.0 0.045 14.2 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.13 CCF38322.1 - 0.013 14.6 0.0 0.02 14.0 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 CCF38322.1 - 0.014 15.0 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 CCF38322.1 - 0.021 15.3 0.0 0.051 14.0 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.12 CCF38322.1 - 0.18 10.8 0.0 0.28 10.2 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Glyco_hydro_43 PF04616.9 CCF38323.1 - 3.2e-32 111.7 3.9 6.7e-31 107.4 2.7 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 DUF2052 PF09747.4 CCF38324.1 - 3.7e-28 98.6 14.6 4e-15 56.2 6.4 2.1 1 1 1 2 2 2 2 Coiled-coil domain containing protein (DUF2052) Glyco_hydro_6 PF01341.12 CCF38325.1 - 1.4e-87 293.9 0.2 1.6e-87 293.7 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 p450 PF00067.17 CCF38326.1 - 2.7e-28 98.7 0.0 2.6e-25 88.8 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 NPP1 PF05630.6 CCF38327.1 - 7.2e-27 94.4 1.1 1.6e-25 90.0 0.7 2.0 1 1 0 1 1 1 1 Necrosis inducing protein (NPP1) WSC PF01822.14 CCF38329.1 - 1.6e-15 56.7 1.8 1.6e-15 56.7 1.2 2.7 3 0 0 3 3 3 1 WSC domain Ank_2 PF12796.2 CCF38332.1 - 8.1e-33 112.6 3.3 9.8e-17 61.0 0.2 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 CCF38332.1 - 3.5e-28 95.9 2.2 1.8e-07 30.6 0.1 5.0 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 CCF38332.1 - 4.9e-26 90.1 9.1 1.5e-09 37.8 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 CCF38332.1 - 6.2e-22 77.5 1.3 5.5e-10 39.4 0.0 4.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF38332.1 - 8.2e-16 56.5 0.0 0.00023 21.1 0.0 4.9 5 0 0 5 5 5 3 Ankyrin repeat Shigella_OspC PF06128.6 CCF38332.1 - 0.028 13.9 1.4 4.3 6.7 0.0 2.9 1 1 2 3 3 3 0 Shigella flexneri OspC protein Epimerase PF01370.16 CCF38333.1 - 1.8e-27 96.3 0.0 2.3e-27 95.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF38333.1 - 2.7e-21 75.5 0.0 3.6e-21 75.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 CCF38333.1 - 1.5e-16 60.1 0.0 3.1e-16 59.0 0.0 1.5 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 CCF38333.1 - 2.8e-15 56.8 0.0 5.4e-15 55.8 0.0 1.4 1 1 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF38333.1 - 1.2e-07 31.2 0.0 2.6e-07 30.1 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.20 CCF38333.1 - 1.5e-07 31.4 0.0 4.7e-07 29.8 0.0 1.7 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF38333.1 - 3.9e-06 26.6 0.0 9.9e-06 25.3 0.0 1.5 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 CCF38333.1 - 4.2e-06 25.8 0.0 6e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.12 CCF38333.1 - 0.047 12.5 0.0 0.35 9.7 0.0 2.2 3 0 0 3 3 3 0 RmlD substrate binding domain FA_desaturase PF00487.19 CCF38334.1 - 0.028 13.8 0.3 0.035 13.5 0.2 1.1 1 0 0 1 1 1 0 Fatty acid desaturase DUF1772 PF08592.6 CCF38335.1 - 3.6e-18 65.6 3.9 7e-18 64.7 0.1 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF1772) DAO PF01266.19 CCF38336.1 - 3.4e-49 167.6 3.6 5.3e-49 167.0 2.5 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF38336.1 - 0.012 15.6 0.0 0.038 14.0 0.0 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF38336.1 - 0.02 14.9 0.5 0.55 10.2 0.3 2.2 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF38336.1 - 0.028 14.1 0.2 1.5 8.6 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Glyco_transf_28 PF03033.15 CCF38337.1 - 1.3e-17 63.9 0.1 1.4e-16 60.4 0.1 2.5 1 1 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.13 CCF38337.1 - 0.0013 17.3 0.0 0.0029 16.2 0.0 1.5 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 CCF38337.1 - 0.096 12.3 0.0 0.25 10.9 0.0 1.7 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain Proteasome PF00227.21 CCF38339.1 - 1.2e-45 155.1 0.0 1.6e-45 154.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 CCF38339.1 - 1.8e-13 49.5 0.2 3.8e-13 48.4 0.2 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF550 PF04447.7 CCF38339.1 - 0.08 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF550) SCP2 PF02036.12 CCF38339.1 - 0.13 12.5 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 SCP-2 sterol transfer family DUF2373 PF10180.4 CCF38340.1 - 9.7e-22 76.2 0.4 1.7e-21 75.5 0.3 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) zf-C2H2 PF00096.21 CCF38341.1 - 1.3e-09 37.8 24.9 4e-06 26.8 1.8 3.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CCF38341.1 - 3.1e-08 33.5 14.7 6.5e-07 29.3 4.4 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 CCF38341.1 - 6.6e-07 29.2 21.3 0.00011 22.2 3.6 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CCF38341.1 - 3.1e-06 27.1 7.2 0.00032 20.7 0.7 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CCF38341.1 - 4.9e-06 26.5 6.5 4.3e-05 23.5 0.2 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 CCF38341.1 - 0.0051 16.6 10.6 0.0068 16.2 0.8 3.0 2 1 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_2 PF12756.2 CCF38341.1 - 0.76 9.9 5.1 12 6.0 0.3 2.5 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-BED PF02892.10 CCF38341.1 - 1.5 8.6 8.5 1.9 8.2 3.2 2.5 1 1 1 2 2 2 0 BED zinc finger Elf1 PF05129.8 CCF38341.1 - 1.7 8.3 4.6 10 5.8 0.4 2.5 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like NCD3G PF07562.9 CCF38341.1 - 3.9 7.2 7.8 0.75 9.5 0.8 2.9 3 0 0 3 3 3 0 Nine Cysteines Domain of family 3 GPCR TRAM_LAG1_CLN8 PF03798.11 CCF38342.1 - 6.9e-34 117.1 18.3 1.4e-33 116.1 12.7 1.5 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.6 CCF38342.1 - 2.4e-23 81.3 0.0 5.3e-23 80.3 0.0 1.6 1 0 0 1 1 1 1 TRAM1-like protein But2 PF09792.4 CCF38344.1 - 2.9e-05 23.8 0.0 3.7e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain WD40 PF00400.27 CCF38345.1 - 1.7e-14 53.0 5.8 1.8e-10 40.3 0.0 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat Nucleoporin_N PF08801.6 CCF38345.1 - 0.025 13.3 0.1 0.33 9.6 0.0 2.5 2 1 0 2 2 2 0 Nup133 N terminal like SUR7 PF06687.7 CCF38346.1 - 3.8e-36 124.6 11.7 4.6e-36 124.3 8.1 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF4064 PF13273.1 CCF38346.1 - 0.016 15.2 0.7 0.016 15.2 0.5 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) RCR PF12273.3 CCF38346.1 - 0.03 14.8 0.1 0.055 14.0 0.1 1.5 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Orai-1 PF07856.7 CCF38347.1 - 0.07 12.6 0.0 0.07 12.6 0.0 1.1 1 0 0 1 1 1 0 Mediator of CRAC channel activity FlgD_ig PF13860.1 CCF38348.1 - 0.0026 17.4 0.3 0.0081 15.8 0.0 2.0 2 0 0 2 2 2 1 FlgD Ig-like domain Dynamitin PF04912.9 CCF38349.1 - 1.8e-15 56.6 5.3 5.7e-15 55.0 3.7 1.7 1 1 0 1 1 1 1 Dynamitin Spore_III_AB PF09548.5 CCF38349.1 - 0.033 13.9 0.7 0.64 9.7 0.1 2.6 2 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) FH2 PF02181.18 CCF38349.1 - 0.057 12.2 0.7 0.47 9.2 0.0 2.0 2 0 0 2 2 2 0 Formin Homology 2 Domain FlgN PF05130.7 CCF38349.1 - 0.065 13.4 0.9 0.065 13.4 0.6 2.0 2 1 0 2 2 2 0 FlgN protein CENP-F_leu_zip PF10473.4 CCF38349.1 - 0.38 10.5 5.9 3.4 7.5 1.0 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SlyX PF04102.7 CCF38349.1 - 2.4 8.6 6.2 19 5.7 0.7 3.3 2 1 1 3 3 3 0 SlyX DUF1192 PF06698.6 CCF38349.1 - 6.9 6.5 7.9 1.3 8.8 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) RTC4 PF14474.1 CCF38350.1 - 5.1e-31 107.1 0.0 1e-30 106.2 0.0 1.5 1 0 0 1 1 1 1 RTC4-like domain Zn-ribbon_8 PF09723.5 CCF38350.1 - 0.078 12.9 0.2 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 Zinc ribbon domain TauD PF02668.11 CCF38351.1 - 5.6e-50 170.4 0.0 7.3e-50 170.0 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.11 CCF38352.1 - 2.3e-22 79.2 19.3 3.2e-22 78.7 13.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily B12D PF06522.6 CCF38352.1 - 0.13 12.0 0.2 0.59 9.8 0.0 2.1 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit Fungal_trans PF04082.13 CCF38353.1 - 1.2e-12 47.2 0.0 2e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF38353.1 - 3.4e-08 33.2 5.7 5.8e-08 32.5 3.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Alpha-amylase PF00128.19 CCF38354.1 - 7.7e-31 107.6 0.1 1.7e-30 106.5 0.0 1.6 2 0 0 2 2 2 1 Alpha amylase, catalytic domain DUF3459 PF11941.3 CCF38354.1 - 0.0021 18.1 0.0 0.0093 16.0 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3459) Alpha-amylase_C PF02806.13 CCF38354.1 - 0.004 17.2 0.0 0.014 15.5 0.0 2.0 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Glyco_hydro_42C PF08533.5 CCF38354.1 - 0.058 12.9 0.0 0.51 9.8 0.0 2.5 2 1 0 2 2 2 0 Beta-galactosidase C-terminal domain CBS PF00571.23 CCF38355.1 - 1.6e-17 63.0 3.5 1.2e-06 28.2 0.1 5.6 5 1 0 5 5 5 4 CBS domain BioY PF02632.9 CCF38356.1 - 0.082 12.5 0.0 0.099 12.2 0.0 1.2 1 0 0 1 1 1 0 BioY family Zn_clus PF00172.13 CCF38357.1 - 1.6e-07 31.0 10.7 3.2e-07 30.1 7.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF38357.1 - 4.7e-05 22.1 0.1 0.0014 17.3 0.0 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain p450 PF00067.17 CCF38358.1 - 7.9e-73 245.5 0.0 9.5e-73 245.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Hydrolase PF00702.21 CCF38359.1 - 5.6e-10 40.0 0.0 2e-09 38.1 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 CCF38359.1 - 4.6e-09 36.7 0.0 9.6e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CCF38359.1 - 0.0008 19.0 0.1 0.067 12.7 0.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Ribosomal_L7Ae PF01248.21 CCF38359.1 - 0.0019 17.6 0.0 0.0041 16.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Hydrolase_6 PF13344.1 CCF38359.1 - 0.09 12.6 0.0 0.28 11.0 0.0 1.8 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Ctr PF04145.10 CCF38360.1 - 2.7e-27 95.5 2.1 3.3e-27 95.2 1.4 1.1 1 0 0 1 1 1 1 Ctr copper transporter family ADIP PF11559.3 CCF38361.1 - 2.1e-40 138.0 5.0 5e-40 136.8 3.5 1.7 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding DegS PF05384.6 CCF38361.1 - 0.097 11.8 5.0 0.22 10.7 3.5 1.5 1 0 0 1 1 1 0 Sensor protein DegS DUF641 PF04859.7 CCF38361.1 - 0.16 11.6 2.8 2 8.1 1.0 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Atg14 PF10186.4 CCF38361.1 - 0.22 10.4 7.3 0.48 9.3 5.0 1.5 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 AdoMet_MTase PF07757.8 CCF38362.1 - 1e-38 131.8 0.0 1.8e-38 131.1 0.0 1.4 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_23 PF13489.1 CCF38362.1 - 0.0085 15.8 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF38362.1 - 0.13 12.8 0.0 0.38 11.3 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain DUF726 PF05277.7 CCF38364.1 - 3.2e-09 36.1 10.1 4.6e-09 35.6 7.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Gly-zipper_OmpA PF13436.1 CCF38364.1 - 2.3 7.9 10.9 6.5 6.4 7.5 1.8 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain p450 PF00067.17 CCF38365.1 - 1.3e-67 228.3 0.0 1.6e-67 228.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Sec23_trunk PF04811.10 CCF38366.1 - 6.2e-36 123.9 0.0 8.9e-36 123.4 0.0 1.1 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.10 CCF38366.1 - 3.6e-18 64.8 5.1 5.8e-18 64.1 3.6 1.3 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger PTR2 PF00854.16 CCF38367.1 - 0.0013 17.6 0.2 0.0014 17.4 0.2 1.0 1 0 0 1 1 1 1 POT family EI24 PF07264.6 CCF38367.1 - 0.03 13.7 0.1 0.031 13.6 0.1 1.1 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) FixQ PF05545.6 CCF38367.1 - 0.32 10.6 1.9 0.53 9.9 1.3 1.3 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Cyclin PF08613.6 CCF38368.1 - 2.9e-39 134.8 1.5 3.9e-23 82.5 0.1 2.4 2 0 0 2 2 2 2 Cyclin Glyoxalase_2 PF12681.2 CCF38369.1 - 3.4e-07 30.8 0.0 4.1e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.20 CCF38369.1 - 0.0064 16.4 0.1 0.024 14.5 0.1 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Peptidase_M16_C PF05193.16 CCF38370.1 - 8.6e-33 113.5 0.0 2.7e-19 69.5 0.0 3.0 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 CCF38370.1 - 3e-31 108.1 0.4 9.4e-31 106.5 0.1 2.0 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) CotH PF08757.6 CCF38372.1 - 0.1 11.8 0.0 0.1 11.8 0.0 1.8 2 0 0 2 2 2 0 CotH protein Mitofilin PF09731.4 CCF38372.1 - 1 7.9 8.9 1.3 7.6 6.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein PAT1 PF09770.4 CCF38372.1 - 4.8 5.2 30.4 5.6 5.0 21.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hid1 PF12722.2 CCF38372.1 - 5.2 4.6 4.9 5.6 4.5 3.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1925 PF09094.6 CCF38373.1 - 0.093 12.7 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1925) F-protein PF00469.15 CCF38374.1 - 0.21 10.9 2.2 0.27 10.5 1.5 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef DUF2151 PF10221.4 CCF38374.1 - 4.2 5.4 7.7 6.1 4.8 4.9 1.5 1 1 1 2 2 2 0 Cell cycle and development regulator PBP1_TM PF14812.1 CCF38374.1 - 4.9 7.5 10.4 3.3 8.0 6.0 1.7 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RNase_H2-Ydr279 PF09468.5 CCF38374.1 - 7.6 5.6 8.4 11 5.0 5.8 1.4 1 1 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Myb_DNA-bind_4 PF13837.1 CCF38375.1 - 0.036 14.2 0.1 0.039 14.0 0.1 1.1 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain H2TH PF06831.9 CCF38377.1 - 5.8e-19 67.6 0.0 9.6e-19 66.9 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Fapy_DNA_glyco PF01149.19 CCF38377.1 - 1.7e-14 54.1 0.0 3.4e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain FbpA PF05833.6 CCF38377.1 - 0.0031 16.1 0.0 0.11 11.0 0.0 2.2 2 0 0 2 2 2 2 Fibronectin-binding protein A N-terminus (FbpA) Cupin_2 PF07883.6 CCF38378.1 - 0.14 11.7 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Cupin domain FAD_binding_3 PF01494.14 CCF38380.1 - 3.2e-19 69.2 0.0 1.1e-18 67.4 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF38380.1 - 0.00022 20.2 0.1 0.065 12.1 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 CCF38380.1 - 0.00027 21.2 0.1 0.64 10.4 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF38380.1 - 0.00074 19.4 0.0 0.0015 18.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF38380.1 - 0.003 17.4 0.1 0.006 16.4 0.1 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF38380.1 - 0.016 13.8 0.0 0.52 8.8 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase OPT PF03169.10 CCF38382.1 - 1.8e-82 277.7 45.8 2.3e-82 277.4 31.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Bax1-I PF01027.15 CCF38384.1 - 3.8e-32 111.5 10.7 3.8e-32 111.5 7.4 1.8 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 PMSR PF01625.16 CCF38385.1 - 2.3e-56 189.9 0.1 2.8e-56 189.7 0.0 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase E1-E2_ATPase PF00122.15 CCF38387.1 - 2e-63 213.5 7.8 2e-63 213.5 5.4 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CCF38387.1 - 1.1e-29 103.3 5.7 1.1e-29 103.3 3.9 2.4 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CCF38387.1 - 1.9e-27 97.1 0.1 4.3e-26 92.6 0.1 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF38387.1 - 3.1e-15 55.9 0.0 6.3e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 CCF38387.1 - 4.7e-15 54.8 0.0 1.2e-14 53.4 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 CCF38387.1 - 6.5e-12 46.0 0.5 1.7e-11 44.6 0.4 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CCF38387.1 - 3.3e-06 26.8 1.1 4.4e-05 23.1 0.3 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Adap_comp_sub PF00928.16 CCF38390.1 - 1.7e-82 276.4 0.0 2.3e-82 276.0 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 CCF38390.1 - 5.1e-09 35.9 0.2 8.4e-09 35.2 0.1 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TauD PF02668.11 CCF38391.1 - 0.011 15.4 0.0 0.019 14.6 0.0 1.3 1 1 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family DAO PF01266.19 CCF38392.1 - 1.4e-39 136.0 0.0 1.8e-39 135.6 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF38392.1 - 7.4e-07 29.1 0.1 1.8e-06 27.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF38392.1 - 2.8e-05 24.2 0.0 0.026 14.5 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CCF38392.1 - 7.8e-05 22.6 0.0 0.0029 17.4 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF38392.1 - 0.00034 20.9 0.0 0.00071 19.9 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF38392.1 - 0.00066 19.4 0.0 0.006 16.3 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.14 CCF38392.1 - 0.0027 16.8 0.0 0.005 15.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain 3HCDH_N PF02737.13 CCF38392.1 - 0.0029 17.2 0.0 0.0041 16.7 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.10 CCF38392.1 - 0.0041 16.9 0.0 0.0068 16.2 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.18 CCF38392.1 - 0.009 15.7 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GIDA PF01134.17 CCF38392.1 - 0.017 13.9 0.0 1.7 7.4 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A UDPG_MGDP_dh_N PF03721.9 CCF38392.1 - 0.02 14.3 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain HI0933_like PF03486.9 CCF38392.1 - 0.031 12.7 0.0 0.11 10.8 0.0 1.8 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.12 CCF38392.1 - 0.039 13.0 0.0 0.078 12.0 0.0 1.4 1 0 0 1 1 1 0 Thi4 family TrkA_N PF02254.13 CCF38392.1 - 0.061 13.3 0.0 0.14 12.1 0.0 1.6 2 0 0 2 2 1 0 TrkA-N domain ApbA PF02558.11 CCF38392.1 - 0.073 12.5 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_binding_2 PF00890.19 CCF38392.1 - 0.1 11.4 0.0 0.23 10.2 0.0 1.6 1 0 0 1 1 1 0 FAD binding domain K_oxygenase PF13434.1 CCF38392.1 - 0.12 11.2 0.0 0.27 10.1 0.0 1.5 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) 2-Hacid_dh_C PF02826.14 CCF38392.1 - 0.15 11.1 0.0 0.25 10.4 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF4449 PF14613.1 CCF38393.1 - 3.6e-69 231.8 2.7 6.6e-69 231.0 1.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4449) YlqD PF11068.3 CCF38393.1 - 0.0058 16.6 4.4 0.0094 15.9 2.4 1.9 1 1 0 1 1 1 1 YlqD protein Prp18 PF02840.10 CCF38393.1 - 0.25 11.1 2.6 0.25 11.1 0.0 2.3 3 1 1 4 4 4 0 Prp18 domain adh_short PF00106.20 CCF38394.1 - 5.7e-23 81.6 1.3 1e-22 80.8 0.9 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF38394.1 - 7e-08 32.5 0.0 1.7e-07 31.2 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF38394.1 - 0.00014 21.5 0.1 0.00021 21.0 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF38394.1 - 0.075 13.0 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 NADH(P)-binding Amidohydro_1 PF01979.15 CCF38396.1 - 3.4e-20 72.9 2.4 1e-09 38.5 0.0 3.1 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_4 PF13147.1 CCF38396.1 - 8.3e-15 55.5 4.8 6.3e-12 46.0 3.3 2.8 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_5 PF13594.1 CCF38396.1 - 4e-09 36.1 0.1 1.3e-08 34.4 0.0 1.9 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_3 PF07969.6 CCF38396.1 - 3.1e-08 33.2 1.7 2.9e-05 23.4 0.1 2.7 3 0 0 3 3 3 2 Amidohydrolase family Aldo_ket_red PF00248.16 CCF38397.1 - 1.1e-65 221.3 0.0 1.3e-65 221.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family polyprenyl_synt PF00348.12 CCF38398.1 - 1.2e-39 135.6 0.0 2.6e-39 134.6 0.0 1.6 1 0 0 1 1 1 1 Polyprenyl synthetase Phage_lysis PF03245.8 CCF38398.1 - 0.04 13.9 1.3 0.63 10.0 0.1 2.4 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein DUF4650 PF15509.1 CCF38398.1 - 0.088 11.7 2.7 0.16 10.8 1.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4650) p450 PF00067.17 CCF38399.1 - 2e-52 178.2 0.0 3e-52 177.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Ribosomal_L16 PF00252.13 CCF38399.1 - 0.021 14.5 0.0 0.039 13.7 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L16p/L10e DUF3328 PF11807.3 CCF38400.1 - 1.5e-35 122.8 1.0 2.1e-35 122.4 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Cypo_polyhedrin PF05865.6 CCF38400.1 - 0.012 14.8 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 Cypovirus polyhedrin protein ADH_zinc_N PF00107.21 CCF38401.1 - 1.6e-05 24.4 0.4 3.5e-05 23.3 0.3 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase SR-25 PF10500.4 CCF38401.1 - 0.24 10.8 8.6 0.37 10.2 5.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein UbiA PF01040.13 CCF38402.1 - 1.1e-28 100.2 13.3 1.7e-28 99.5 9.2 1.3 1 1 0 1 1 1 1 UbiA prenyltransferase family LCM PF04072.9 CCF38403.1 - 7.5e-11 41.9 0.0 1.1e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase NUC153 PF08159.7 CCF38404.1 - 4.6e-12 45.3 2.2 1e-11 44.2 1.5 1.6 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.27 CCF38404.1 - 6.5e-05 22.6 0.1 0.048 13.5 0.0 4.0 4 0 0 4 4 4 1 WD domain, G-beta repeat Rax2 PF12768.2 CCF38407.1 - 1.3e-08 34.4 11.8 0.00094 18.4 1.3 3.5 2 2 1 3 3 3 3 Cortical protein marker for cell polarity Kelch_4 PF13418.1 CCF38407.1 - 2.3 8.0 9.5 1.1 9.0 0.1 4.3 4 1 0 4 4 4 0 Galactose oxidase, central domain Sugar_tr PF00083.19 CCF38408.1 - 4.6e-28 98.0 36.8 2.4e-19 69.2 7.2 2.7 2 1 1 3 3 3 3 Sugar (and other) transporter MFS_1 PF07690.11 CCF38408.1 - 1.6e-21 76.3 27.6 5.1e-15 55.0 12.0 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Dynamin_N PF00350.18 CCF38409.1 - 2.7e-29 102.1 0.0 6.1e-29 100.9 0.0 1.7 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 CCF38409.1 - 5.1e-17 61.6 0.0 1e-16 60.6 0.0 1.5 1 0 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.18 CCF38409.1 - 0.0019 18.1 0.0 0.013 15.4 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CCF38409.1 - 0.008 16.6 0.0 0.019 15.4 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein GED PF02212.13 CCF38409.1 - 0.019 14.8 1.8 0.057 13.3 0.1 2.6 3 0 0 3 3 3 0 Dynamin GTPase effector domain AAA_21 PF13304.1 CCF38409.1 - 0.051 13.5 0.1 0.42 10.5 0.0 2.4 2 1 0 2 2 2 0 AAA domain Chitin_synth_2 PF03142.10 CCF38410.1 - 9.8e-41 139.7 4.1 1.6e-31 109.2 0.2 2.4 2 1 0 2 2 2 2 Chitin synthase Glycos_transf_2 PF00535.21 CCF38410.1 - 6.4e-09 35.7 0.0 0.00041 20.0 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.1 CCF38410.1 - 5.9e-08 32.6 3.3 5.9e-08 32.6 2.3 2.8 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 CCF38410.1 - 1.1e-07 31.8 0.4 0.0023 17.7 0.0 3.1 3 0 0 3 3 3 3 Glycosyltransferase like family 2 DUF2207 PF09972.4 CCF38410.1 - 1.3 7.5 9.9 0.25 9.8 0.2 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) p450 PF00067.17 CCF38412.1 - 1.2e-72 244.9 0.0 1.6e-72 244.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 LRR19-TM PF15176.1 CCF38413.1 - 0.0049 16.5 0.0 3.4 7.4 0.0 2.7 2 0 0 2 2 2 2 Leucine-rich repeat family 19 TM domain DUF3377 PF11857.3 CCF38413.1 - 1.4 8.5 0.0 1.4 8.5 0.0 4.1 4 1 1 5 5 5 0 Domain of unknown function (DUF3377) DUF4131 PF13567.1 CCF38413.1 - 7 6.0 15.7 2.3 7.6 2.4 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4131) CLTH PF10607.4 CCF38414.1 - 6.7e-30 103.6 0.0 1.2e-29 102.9 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.1 CCF38414.1 - 1.7e-20 72.4 4.0 3.9e-20 71.2 2.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.1 CCF38414.1 - 4.9e-07 29.3 2.2 8.1e-07 28.6 1.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 CCF38414.1 - 3.2e-06 26.8 2.4 5.7e-06 26.0 1.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 CCF38414.1 - 1.8e-05 24.6 3.3 3.1e-05 23.8 2.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF38414.1 - 1.9e-05 24.2 1.5 3.3e-05 23.4 1.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.7 CCF38414.1 - 0.00029 20.1 0.1 0.0005 19.3 0.1 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger zf-C3HC4 PF00097.20 CCF38414.1 - 0.00033 20.2 3.5 0.0006 19.4 2.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CCF38414.1 - 0.0018 18.0 3.7 0.0037 17.0 2.5 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.1 CCF38414.1 - 0.066 12.8 2.1 0.12 12.0 1.5 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.1 CCF38414.1 - 0.088 12.3 1.2 0.2 11.2 0.8 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-MIZ PF02891.15 CCF38414.1 - 0.16 11.5 2.4 0.31 10.5 1.7 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Ctr PF04145.10 CCF38415.1 - 8.2e-41 139.4 0.7 1.1e-40 139.0 0.5 1.2 1 0 0 1 1 1 1 Ctr copper transporter family DUF1180 PF06679.7 CCF38415.1 - 0.31 10.9 1.8 0.37 10.6 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Hemerythrin PF01814.18 CCF38416.1 - 2.6e-10 40.5 0.0 3.4e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Peptidase_C12 PF01088.16 CCF38417.1 - 6.9e-55 185.5 0.0 8.2e-55 185.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Glyoxalase_2 PF12681.2 CCF38417.1 - 0.056 14.0 0.0 0.091 13.3 0.0 1.4 1 0 0 1 1 1 0 Glyoxalase-like domain TPR_11 PF13414.1 CCF38418.1 - 9.4e-57 188.5 32.9 1.5e-16 59.7 1.5 6.4 5 1 1 6 6 6 6 TPR repeat TPR_1 PF00515.23 CCF38418.1 - 3.8e-45 149.6 20.2 1.1e-07 31.1 0.1 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.12 CCF38418.1 - 1.6e-37 124.3 22.1 1.2e-05 24.7 0.1 9.7 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_12 PF13424.1 CCF38418.1 - 2.4e-20 72.2 14.8 7.4e-13 48.2 0.9 5.5 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.1 CCF38418.1 - 1.6e-19 70.0 10.8 0.00043 20.8 0.1 6.8 3 3 5 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.1 CCF38418.1 - 1.7e-18 64.9 17.1 0.00035 20.1 0.2 8.0 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.1 CCF38418.1 - 1.6e-17 62.3 9.7 0.37 11.5 0.0 8.8 5 3 4 9 9 8 5 Tetratricopeptide repeat TPR_17 PF13431.1 CCF38418.1 - 2e-16 58.7 7.2 0.0034 17.4 0.1 7.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.1 CCF38418.1 - 4e-16 57.4 13.4 3.8e-05 23.1 0.1 8.1 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_19 PF14559.1 CCF38418.1 - 1.9e-13 50.5 7.7 2e-05 24.8 0.0 5.8 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.1 CCF38418.1 - 1.8e-12 46.9 1.1 0.00051 19.8 0.0 5.6 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.1 CCF38418.1 - 4.6e-08 32.9 7.4 0.76 10.3 0.0 7.5 6 1 0 6 6 6 1 Tetratricopeptide repeat Apc3 PF12895.2 CCF38418.1 - 0.0002 21.3 9.2 0.00052 20.1 1.5 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.1 CCF38418.1 - 0.00031 20.5 4.0 0.011 15.7 0.0 4.8 5 0 0 5 5 4 1 Tetratricopeptide repeat SHNi-TPR PF10516.4 CCF38418.1 - 0.00045 19.4 1.1 1.5 8.1 0.1 4.5 5 0 0 5 5 5 1 SHNi-TPR TPR_3 PF07720.7 CCF38418.1 - 0.072 12.9 0.3 0.072 12.9 0.2 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.13 CCF38418.1 - 0.13 12.1 21.8 0.25 11.2 0.5 5.8 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain MFS_1 PF07690.11 CCF38419.1 - 6.4e-40 136.9 48.4 6.4e-40 136.9 33.5 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF38419.1 - 1.6e-08 33.2 26.3 2e-08 32.8 18.2 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3318 PF11780.3 CCF38419.1 - 0.046 13.2 1.4 0.086 12.4 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3318) SSP160 PF06933.6 CCF38420.1 - 0.014 13.4 11.4 0.022 12.7 7.9 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Adaptin_N PF01602.15 CCF38421.1 - 8.1e-123 410.5 3.3 9.2e-123 410.3 2.3 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 CCF38421.1 - 9.6e-07 28.9 0.4 0.062 13.5 0.1 3.8 2 2 1 3 3 3 2 HEAT repeats Cnd1 PF12717.2 CCF38421.1 - 4.6e-05 23.3 4.0 0.017 14.9 0.3 3.5 2 2 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 CCF38421.1 - 0.0003 20.6 2.5 4.2 7.7 0.0 5.2 4 1 1 5 5 5 1 HEAT repeat HEAT_EZ PF13513.1 CCF38421.1 - 0.00042 20.7 2.8 4.6 7.8 0.1 4.6 4 1 0 4 4 4 1 HEAT-like repeat DUF3730 PF12530.3 CCF38421.1 - 0.00044 20.2 0.0 0.0016 18.4 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3730) TIP120 PF08623.5 CCF38421.1 - 0.00066 19.3 0.7 0.016 14.7 0.0 3.1 2 2 1 3 3 3 1 TATA-binding protein interacting (TIP20) RIX1 PF08167.7 CCF38421.1 - 0.0077 15.9 0.0 0.15 11.6 0.0 2.6 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis Arm PF00514.18 CCF38421.1 - 0.053 13.3 0.7 51 3.9 0.1 4.3 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat API5 PF05918.6 CCF38421.1 - 0.056 11.9 0.5 0.17 10.3 0.0 1.9 2 0 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) Vac14_Fab1_bd PF12755.2 CCF38421.1 - 0.062 13.6 0.5 2.8 8.3 0.0 3.4 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region Cohesin_HEAT PF12765.2 CCF38421.1 - 0.089 12.7 0.6 0.33 10.9 0.1 2.4 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion EF-hand_1 PF00036.27 CCF38422.1 - 2.8e-41 135.6 12.8 1.1e-09 36.9 0.6 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 CCF38422.1 - 1.7e-36 124.1 5.8 6.4e-20 71.0 1.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 CCF38422.1 - 8.5e-35 118.1 12.2 6.8e-16 57.6 0.5 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 CCF38422.1 - 1.2e-30 102.6 8.0 1.2e-09 37.2 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 CCF38422.1 - 5.2e-26 88.7 9.7 1.4e-06 27.3 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.1 CCF38422.1 - 1.3e-15 57.0 0.3 2.2e-08 33.9 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 CCF38422.1 - 2.6e-09 36.7 1.9 0.00056 19.6 0.2 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 CCF38422.1 - 1.5e-08 34.6 0.1 0.0038 17.2 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.8 CCF38422.1 - 3.2e-08 33.0 0.1 0.022 14.3 0.0 3.3 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.5 CCF38422.1 - 4.4e-07 29.7 2.1 4.5e-06 26.5 0.2 2.3 2 1 0 2 2 2 1 Ca2+ insensitive EF hand TerB PF05099.8 CCF38422.1 - 0.00014 21.5 0.3 0.32 10.7 0.0 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.8 CCF38422.1 - 0.00023 20.7 0.2 0.075 12.5 0.0 2.7 1 1 1 3 3 3 1 Caleosin related protein Tenui_NCP PF04876.7 CCF38422.1 - 0.0025 17.3 0.1 0.13 11.8 0.0 2.3 1 1 1 2 2 2 1 Tenuivirus major non-capsid protein RNA_pol_Rpb4 PF03874.11 CCF38422.1 - 0.0026 17.7 0.7 1.3 9.0 0.0 2.6 3 0 0 3 3 3 2 RNA polymerase Rpb4 Toprim_2 PF13155.1 CCF38422.1 - 0.0083 16.4 1.3 2.5 8.4 0.0 2.5 1 1 2 3 3 3 2 Toprim-like DUF3349 PF11829.3 CCF38422.1 - 0.021 15.2 0.4 12 6.4 0.0 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) EF-hand_10 PF14788.1 CCF38422.1 - 0.14 11.8 2.5 0.83 9.3 0.1 3.1 1 1 3 4 4 4 0 EF hand RloB PF13707.1 CCF38422.1 - 0.38 10.3 4.1 0.99 9.0 1.1 2.2 1 1 0 2 2 2 0 RloB-like protein PB1 PF00564.19 CCF38422.1 - 0.45 10.2 2.8 35 4.1 0.0 3.3 2 1 1 3 3 3 0 PB1 domain CFEM PF05730.6 CCF38423.1 - 6.8e-05 22.6 3.4 0.0001 22.0 2.4 1.3 1 0 0 1 1 1 1 CFEM domain DUF2561 PF10812.3 CCF38423.1 - 0.046 13.3 1.1 0.074 12.6 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) Defensin_2 PF01097.13 CCF38423.1 - 0.12 12.0 4.0 0.22 11.2 2.7 1.4 1 0 0 1 1 1 0 Arthropod defensin DUF1056 PF06341.6 CCF38423.1 - 3.6 7.6 6.5 1.1 9.3 0.8 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1056) GST_N_3 PF13417.1 CCF38424.1 - 2.4e-05 24.4 0.0 5.9e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 CCF38424.1 - 0.038 14.0 0.0 0.091 12.7 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 CCF38424.1 - 0.1 12.8 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain CheR_N PF03705.10 CCF38425.1 - 0.11 11.9 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 CheR methyltransferase, all-alpha domain UCR_Fe-S_N PF10399.4 CCF38427.1 - 0.26 10.4 2.3 0.45 9.7 1.6 1.3 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Sugar_tr PF00083.19 CCF38428.1 - 1.9e-27 95.9 9.6 7.2e-27 94.0 4.6 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter RNase_H PF00075.19 CCF38429.1 - 6.3e-12 45.9 0.0 1e-11 45.2 0.0 1.3 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.1 CCF38429.1 - 0.085 12.6 0.2 0.34 10.7 0.1 1.9 1 1 0 1 1 1 0 Reverse transcriptase-like Zn_clus PF00172.13 CCF38430.1 - 1.7e-08 34.2 10.3 2.7e-08 33.5 7.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF38430.1 - 0.0075 14.9 0.7 0.064 11.8 0.1 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF2183 PF09949.4 CCF38431.1 - 7.2e-29 99.6 0.0 1.5e-28 98.6 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) Polyketide_cyc2 PF10604.4 CCF38432.1 - 0.03 14.4 4.1 0.43 10.7 2.8 2.4 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport Hex_IIIa PF02455.11 CCF38432.1 - 1.8 7.1 7.5 2.5 6.6 5.2 1.1 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) Herpes_capsid PF06112.6 CCF38433.1 - 1.8 8.5 8.2 2.2 8.3 5.7 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein FRG2 PF15315.1 CCF38434.1 - 0.3 11.0 11.0 0.81 9.6 0.1 2.1 2 0 0 2 2 2 0 Facioscapulohumeral muscular dystrophy candidate 2 Pex2_Pex12 PF04757.9 CCF38435.1 - 9.9e-40 136.3 4.0 1.3e-39 135.9 2.8 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.1 CCF38435.1 - 1e-11 44.4 8.1 1.6e-11 43.8 5.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 CCF38435.1 - 4e-11 42.7 7.7 6e-11 42.1 5.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF38435.1 - 3.4e-10 39.4 6.4 5.2e-10 38.8 4.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF38435.1 - 1.5e-09 37.3 5.9 2.4e-09 36.6 4.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF38435.1 - 3.3e-08 33.1 5.5 5e-08 32.5 3.8 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 CCF38435.1 - 3.4e-06 26.8 7.7 5.5e-06 26.1 5.3 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 CCF38435.1 - 8.8e-05 22.5 6.5 0.0002 21.3 4.5 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_6 PF14835.1 CCF38435.1 - 9e-05 22.1 2.9 0.00016 21.3 2.0 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.1 CCF38435.1 - 0.0014 18.2 4.6 0.0034 17.0 3.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-Nse PF11789.3 CCF38435.1 - 0.0047 16.4 0.6 0.0072 15.8 0.4 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-Apc11 PF12861.2 CCF38435.1 - 0.045 13.5 1.6 0.08 12.7 1.1 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 CCF38435.1 - 0.067 12.7 8.0 0.12 11.9 5.6 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF3773 PF12608.3 CCF38435.1 - 0.088 12.8 0.5 28 4.8 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3773) IBR PF01485.16 CCF38435.1 - 2 8.3 6.7 5.7 6.8 4.7 1.7 1 1 0 1 1 1 0 IBR domain CN_hydrolase PF00795.17 CCF38436.1 - 2.6e-28 98.6 0.0 3.4e-28 98.2 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Rep_fac-A_3 PF08661.6 CCF38438.1 - 7.2e-20 70.9 0.0 7.9e-20 70.7 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 GST_N_3 PF13417.1 CCF38439.1 - 7.9e-08 32.4 0.0 2.3e-07 30.9 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 CCF38439.1 - 4.5e-07 29.7 0.0 1e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 CCF38439.1 - 6.2e-07 29.3 0.1 1.2e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 CCF38439.1 - 2.8e-06 27.1 0.3 1.6e-05 24.6 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 CCF38439.1 - 3.8e-06 26.9 0.0 8.7e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 CCF38439.1 - 2.9e-05 24.4 0.3 4.5e-05 23.8 0.2 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Fungal_trans PF04082.13 CCF38440.1 - 4.2e-26 91.3 0.0 6.1e-26 90.8 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF38440.1 - 3.1e-07 30.2 8.9 6.3e-07 29.2 6.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SIR2 PF02146.12 CCF38441.1 - 7.4e-40 136.5 0.0 1.1e-39 136.0 0.0 1.3 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.17 CCF38441.1 - 0.075 12.7 0.0 3.5 7.3 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain ADH_zinc_N PF00107.21 CCF38442.1 - 4.6e-21 74.7 0.0 7.3e-21 74.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF38442.1 - 3.2e-20 71.9 6.2 5.2e-20 71.2 4.3 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 CCF38442.1 - 1e-06 29.6 0.0 1.9e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 CCF38442.1 - 0.00035 19.7 0.3 0.00055 19.1 0.2 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 CCF38442.1 - 0.0035 17.4 0.0 0.0061 16.6 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Glyco_transf_28 PF03033.15 CCF38444.1 - 0.0035 17.1 0.0 0.0079 15.9 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.13 CCF38444.1 - 0.15 10.6 0.0 0.25 9.8 0.0 1.3 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase Pyr_redox_3 PF13738.1 CCF38445.1 - 2.7e-20 73.3 0.1 4.9e-20 72.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 CCF38445.1 - 1.7e-15 56.2 0.3 1.7e-14 52.9 0.0 2.2 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 CCF38445.1 - 1.1e-11 44.5 0.0 4.5e-11 42.6 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 CCF38445.1 - 3e-06 27.0 0.2 0.0065 16.2 0.0 3.7 3 1 1 4 4 4 1 FAD-NAD(P)-binding K_oxygenase PF13434.1 CCF38445.1 - 3.4e-06 26.2 0.5 4.4e-05 22.5 0.0 2.3 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.19 CCF38445.1 - 8e-06 24.9 0.0 0.12 11.2 0.0 2.6 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF38445.1 - 3.7e-05 23.6 0.0 0.00018 21.4 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.10 CCF38445.1 - 0.001 17.3 0.1 0.1 10.7 0.0 2.4 2 0 0 2 2 2 2 Malate:quinone oxidoreductase (Mqo) Thi4 PF01946.12 CCF38445.1 - 0.044 12.8 0.0 0.26 10.3 0.0 2.1 2 0 0 2 2 2 0 Thi4 family Shikimate_DH PF01488.15 CCF38445.1 - 0.089 12.9 0.1 5.7 7.0 0.0 3.3 4 0 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase DUF348 PF03990.9 CCF38445.1 - 0.33 10.5 3.2 1.2 8.8 2.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF348) HI0933_like PF03486.9 CCF38445.1 - 0.4 9.0 1.0 4.6 5.6 0.7 2.3 2 0 0 2 2 2 0 HI0933-like protein Pkinase PF00069.20 CCF38447.1 - 1.2e-16 60.6 0.0 2.1e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF38447.1 - 2.6e-07 29.9 0.0 4.3e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Methyltransf_23 PF13489.1 CCF38448.1 - 5.8e-12 45.6 0.0 7e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF38448.1 - 2.2e-06 28.1 0.3 1.7e-05 25.3 0.1 2.3 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF38448.1 - 2.4e-06 27.2 0.2 3.3e-05 23.5 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF38448.1 - 7.6e-06 26.3 0.0 1.4e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF38448.1 - 1.8e-05 25.1 0.5 0.00042 20.7 0.2 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF38448.1 - 0.0002 21.6 0.0 0.0031 17.8 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 CCF38448.1 - 0.0024 17.2 0.0 0.0038 16.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.12 CCF38448.1 - 0.0033 16.5 0.0 0.0042 16.1 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.14 CCF38448.1 - 0.011 15.7 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase PrmA PF06325.8 CCF38448.1 - 0.018 14.2 0.0 0.022 13.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.4 CCF38448.1 - 0.019 14.4 0.0 0.022 14.2 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase CMAS PF02353.15 CCF38448.1 - 0.022 13.8 0.0 0.025 13.6 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 CCF38448.1 - 0.08 12.0 0.0 0.27 10.2 0.0 1.9 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF1735 PF08522.5 CCF38448.1 - 0.13 12.7 0.0 0.47 10.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1735) DIOX_N PF14226.1 CCF38449.1 - 1.1e-26 93.6 0.4 1.9e-26 92.8 0.2 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 CCF38449.1 - 5.7e-22 77.8 0.0 1.4e-21 76.6 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Transp_cyt_pur PF02133.10 CCF38450.1 - 1.3e-45 155.8 22.5 1.5e-45 155.5 15.6 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin MFS_1 PF07690.11 CCF38454.1 - 3.9e-24 85.0 21.0 3.9e-24 85.0 14.5 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF3416 PF11896.3 CCF38454.1 - 0.2 11.5 0.2 0.31 10.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3416) Mito_carr PF00153.22 CCF38456.1 - 1.4e-26 91.9 1.4 6.7e-14 51.3 0.1 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Fungal_trans PF04082.13 CCF38457.1 - 1.3e-51 175.0 0.1 1.9e-51 174.4 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 CCF38457.1 - 2.6e-08 33.7 4.3 0.0023 18.1 0.1 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF38457.1 - 4.7e-05 23.4 10.0 0.0096 16.1 0.7 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger p450 PF00067.17 CCF38459.1 - 3.7e-52 177.4 0.0 4.4e-52 177.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF2283 PF10049.4 CCF38460.1 - 0.15 11.9 0.0 0.33 10.8 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2283) TRI12 PF06609.8 CCF38461.1 - 0.00011 20.6 2.8 0.00015 20.1 1.6 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF4235 PF14019.1 CCF38461.1 - 0.072 12.9 0.2 0.21 11.4 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4235) DUF3735 PF12537.3 CCF38461.1 - 0.15 12.1 0.7 0.22 11.5 0.2 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3735) DUF4328 PF14219.1 CCF38461.1 - 0.24 10.6 2.0 0.68 9.2 1.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4328) Zn_clus PF00172.13 CCF38462.1 - 2.1e-08 33.9 10.6 2.7e-08 33.5 7.3 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.17 CCF38463.1 - 4e-14 51.9 0.0 4.7e-14 51.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF924 PF06041.6 CCF38464.1 - 4.9e-44 150.3 0.1 9.2e-44 149.4 0.1 1.4 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF924) Amidohydro_3 PF07969.6 CCF38465.1 - 1.5e-54 185.8 4.5 1.7e-54 185.6 3.1 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 CCF38465.1 - 1.3e-08 34.5 0.1 3.2e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 CCF38465.1 - 9.1e-06 25.5 0.3 0.043 13.4 0.0 2.8 2 1 0 2 2 2 2 Amidohydrolase family Amidohydro_4 PF13147.1 CCF38465.1 - 0.0062 16.5 0.1 0.0062 16.5 0.1 2.3 1 1 0 2 2 2 1 Amidohydrolase Fungal_trans PF04082.13 CCF38466.1 - 1.1e-10 40.8 0.0 2e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF38466.1 - 2.3e-07 30.6 5.4 4.3e-07 29.7 3.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Transp_cyt_pur PF02133.10 CCF38467.1 - 9.4e-41 139.7 24.4 6.9e-24 84.1 8.2 2.0 1 1 1 2 2 2 2 Permease for cytosine/purines, uracil, thiamine, allantoin DUF917 PF06032.7 CCF38468.1 - 2.4e-71 240.1 0.0 4.5e-71 239.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.13 CCF38468.1 - 2.5e-45 154.8 11.7 4.1e-44 150.8 4.5 2.7 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 CCF38468.1 - 4.2e-31 107.8 2.2 1e-27 96.7 0.0 3.1 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region BcrAD_BadFG PF01869.15 CCF38468.1 - 8e-05 22.0 1.5 0.029 13.6 0.2 2.6 2 1 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family StbA PF06406.6 CCF38468.1 - 0.00029 19.8 0.3 0.34 9.8 0.0 2.6 2 0 0 2 2 2 2 StbA protein MutL PF13941.1 CCF38468.1 - 0.00073 17.9 10.0 0.087 11.1 0.5 3.2 2 1 0 3 3 3 2 MutL protein DUF3663 PF12404.3 CCF38468.1 - 0.19 11.5 0.0 0.44 10.3 0.0 1.5 1 0 0 1 1 1 0 Peptidase Zn_clus PF00172.13 CCF38469.1 - 2e-08 33.9 8.4 3.4e-08 33.2 5.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_16 PF00722.16 CCF38470.1 - 6.1e-17 61.5 0.1 8.2e-17 61.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.10 CCF38470.1 - 3.2e-05 22.2 3.0 0.032 12.3 1.8 2.1 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) DHH PF01368.15 CCF38471.1 - 0.00014 21.5 0.0 0.00023 20.8 0.0 1.3 1 0 0 1 1 1 1 DHH family Glyco_hydro_16 PF00722.16 CCF38474.1 - 6e-11 41.9 0.3 4.5e-07 29.3 0.1 2.2 2 0 0 2 2 2 2 Glycosyl hydrolases family 16 SKN1 PF03935.10 CCF38474.1 - 4e-06 25.2 0.0 0.0055 14.9 0.2 2.1 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) HSP70 PF00012.15 CCF38476.1 - 6.8e-20 70.5 2.5 7.2e-20 70.4 1.7 1.0 1 0 0 1 1 1 1 Hsp70 protein DUF4299 PF14132.1 CCF38476.1 - 0.019 14.1 0.3 0.027 13.6 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4299) BACON PF13004.2 CCF38476.1 - 0.063 13.5 0.1 0.1 12.8 0.1 1.4 1 0 0 1 1 1 0 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal 2OG-FeII_Oxy PF03171.15 CCF38479.1 - 0.00087 19.5 0.0 0.0042 17.3 0.0 1.9 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ECH PF00378.15 CCF38481.1 - 1.8e-25 89.4 0.0 3.4e-25 88.5 0.0 1.5 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family ECH_C PF13766.1 CCF38481.1 - 4.2e-22 78.5 0.2 3.4e-18 65.8 0.1 2.8 1 1 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region MFS_1 PF07690.11 CCF38484.1 - 8.9e-34 116.7 31.4 1.3e-33 116.2 21.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF914 PF06027.7 CCF38484.1 - 0.0072 15.2 0.1 0.015 14.1 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) AJAP1_PANP_C PF15298.1 CCF38485.1 - 0.12 12.2 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 AJAP1/PANP C-terminus FA_desaturase PF00487.19 CCF38486.1 - 0.035 13.5 3.7 0.049 13.0 2.6 1.3 1 0 0 1 1 1 0 Fatty acid desaturase DUF2207 PF09972.4 CCF38486.1 - 0.14 10.6 7.5 0.17 10.3 5.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4175 PF13779.1 CCF38486.1 - 4.8 4.7 5.2 6.5 4.3 3.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) VIT1 PF01988.14 CCF38486.1 - 5.6 6.3 7.9 7.1 6.0 5.5 1.2 1 0 0 1 1 1 0 VIT family RseC_MucC PF04246.7 CCF38486.1 - 9.7 5.7 9.6 15 5.1 6.7 1.2 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC VWA_2 PF13519.1 CCF38489.1 - 0.0011 19.1 0.0 0.0024 18.0 0.0 1.4 1 1 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.4 CCF38489.1 - 0.0045 16.8 0.0 0.0059 16.4 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.23 CCF38489.1 - 0.0072 16.0 0.0 0.0098 15.6 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF4122 PF13498.1 CCF38489.1 - 0.0095 15.3 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4122) WD40 PF00400.27 CCF38490.1 - 1.2e-43 145.4 5.9 4.4e-11 42.2 0.1 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.3 CCF38490.1 - 0.0014 16.8 0.5 1.2 7.2 0.0 3.0 1 1 2 3 3 3 2 Nucleoporin Nup120/160 eIF2A PF08662.6 CCF38490.1 - 0.0098 15.6 0.3 0.95 9.1 0.0 2.8 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 CCF38490.1 - 0.023 13.4 0.2 0.11 11.1 0.1 2.3 1 1 0 1 1 1 0 Nup133 N terminal like Cornichon PF03311.9 CCF38491.1 - 4.2e-54 182.0 11.6 4.7e-54 181.9 8.0 1.0 1 0 0 1 1 1 1 Cornichon protein EPV_E5 PF08135.6 CCF38491.1 - 0.068 13.1 1.1 0.068 13.1 0.7 2.9 3 0 0 3 3 3 0 Major transforming protein E5 family HET PF06985.6 CCF38492.1 - 1.5e-30 106.1 0.0 2.9e-30 105.2 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Aconitase PF00330.15 CCF38493.1 - 1.2e-64 218.5 0.0 1e-34 119.8 0.0 3.1 1 1 2 3 3 3 3 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 CCF38493.1 - 2e-21 76.4 0.0 3.8e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain NAD_binding_10 PF13460.1 CCF38494.1 - 3.7e-19 69.4 0.7 5.4e-19 68.9 0.5 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF38494.1 - 5.7e-08 32.4 0.0 8.1e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.20 CCF38494.1 - 0.0033 17.3 0.1 0.0074 16.2 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase DHHA1 PF02272.14 CCF38494.1 - 0.012 15.3 0.0 0.059 13.0 0.1 2.2 2 0 0 2 2 2 0 DHHA1 domain RmlD_sub_bind PF04321.12 CCF38494.1 - 0.016 14.0 1.4 0.031 13.1 0.0 2.0 2 1 0 2 2 2 0 RmlD substrate binding domain 2OG-FeII_Oxy PF03171.15 CCF38495.1 - 0.0001 22.4 0.0 0.00018 21.7 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 CCF38495.1 - 0.0011 19.5 0.0 0.0055 17.2 0.0 2.1 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal PIGA PF08288.7 CCF38496.1 - 1.8e-45 153.2 3.1 4.4e-45 151.9 0.6 2.4 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glycos_transf_1 PF00534.15 CCF38496.1 - 1.5e-29 102.6 0.0 2.2e-29 102.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 CCF38496.1 - 4.4e-18 65.6 0.9 8.1e-18 64.7 0.7 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.1 CCF38496.1 - 6.3e-16 58.7 0.0 1.5e-15 57.5 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 CCF38496.1 - 7.4e-14 52.2 0.0 1.3e-13 51.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.1 CCF38496.1 - 6.3e-06 26.0 0.2 1e-05 25.4 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.1 CCF38496.1 - 0.00014 22.0 0.0 0.00067 19.8 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 DEAD PF00270.24 CCF38497.1 - 9.1e-31 106.6 0.0 1.3e-15 57.3 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 CCF38497.1 - 1.8e-07 31.1 0.0 1.8e-07 31.1 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 CCF38497.1 - 0.037 13.7 0.2 0.091 12.5 0.2 1.6 1 0 0 1 1 1 0 Part of AAA domain ABC2_membrane PF01061.19 CCF38499.1 - 2.4e-22 79.1 24.3 3e-22 78.8 16.8 1.1 1 0 0 1 1 1 1 ABC-2 type transporter PDR_CDR PF06422.7 CCF38499.1 - 0.0011 18.5 0.1 0.0011 18.5 0.0 2.0 2 0 0 2 2 2 1 CDR ABC transporter ABC2_membrane_3 PF12698.2 CCF38499.1 - 0.0015 17.5 16.1 0.0023 17.0 11.1 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein DNA_pol_A PF00476.15 CCF38500.1 - 2.4e-99 332.5 0.0 3.7e-99 331.9 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A Recep_L_domain PF01030.19 CCF38501.1 - 0.0023 17.8 4.9 0.085 12.8 0.1 4.2 1 1 3 4 4 4 1 Receptor L domain Ecm33 PF12454.3 CCF38501.1 - 0.46 10.3 10.0 0.36 10.7 3.9 3.0 3 1 0 3 3 3 0 GPI-anchored cell wall organization protein ADH_N PF08240.7 CCF38502.1 - 9.3e-29 99.3 2.4 2.6e-28 97.9 1.7 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF38502.1 - 2.5e-14 52.9 0.2 4.5e-14 52.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.9 CCF38502.1 - 0.0081 15.5 0.2 0.014 14.8 0.1 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.13 CCF38502.1 - 0.14 12.2 0.1 0.14 12.2 0.1 1.6 2 0 0 2 2 2 0 TrkA-N domain EFP PF01132.15 CCF38502.1 - 0.19 11.4 0.0 0.36 10.5 0.0 1.4 1 0 0 1 1 1 0 Elongation factor P (EF-P) OB domain CENP-N PF05238.8 CCF38504.1 - 4.5e-118 394.7 0.0 5.4e-118 394.5 0.0 1.1 1 0 0 1 1 1 1 Kinetochore protein CHL4 like TatD_DNase PF01026.16 CCF38505.1 - 5.9e-48 163.2 0.0 1.2e-47 162.2 0.0 1.5 1 1 0 1 1 1 1 TatD related DNase IBN_N PF03810.14 CCF38507.1 - 0.027 14.3 0.9 0.3 11.0 0.2 2.4 2 1 0 2 2 2 0 Importin-beta N-terminal domain MRFAP1 PF15155.1 CCF38508.1 - 0.0016 18.7 0.6 0.0026 18.1 0.4 1.3 1 1 0 1 1 1 1 MORF4 family-associated protein1 MscS_porin PF12795.2 CCF38508.1 - 0.018 14.4 4.0 0.074 12.3 1.7 1.9 1 1 0 2 2 2 0 Mechanosensitive ion channel porin domain APH_6_hur PF04655.9 CCF38508.1 - 0.03 13.4 0.9 0.036 13.1 0.6 1.2 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase DUF4407 PF14362.1 CCF38508.1 - 0.041 12.8 0.2 0.05 12.5 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CorA PF01544.13 CCF38508.1 - 0.053 12.5 2.6 0.057 12.4 1.8 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Lebercilin PF15619.1 CCF38508.1 - 0.07 12.5 3.2 0.63 9.4 0.6 2.0 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Atg14 PF10186.4 CCF38508.1 - 0.096 11.6 2.8 0.12 11.3 2.0 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 V-SNARE PF05008.10 CCF38508.1 - 0.12 12.6 2.7 0.31 11.2 0.4 2.3 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Latarcin PF10279.4 CCF38508.1 - 0.21 11.8 5.9 0.29 11.3 0.2 2.4 1 1 1 2 2 2 0 Latarcin precursor PhoU PF01895.14 CCF38508.1 - 0.45 10.9 4.0 3 8.3 1.7 2.2 1 1 1 2 2 2 0 PhoU domain NPV_P10 PF05531.7 CCF38508.1 - 1.1 9.5 3.4 14 5.9 0.5 2.8 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein p450 PF00067.17 CCF38509.1 - 5.4e-44 150.4 0.0 7e-44 150.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_S15 PF02129.13 CCF38510.1 - 1.4e-35 123.0 0.5 1.9e-35 122.6 0.3 1.1 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.2 CCF38510.1 - 7.3e-10 39.1 0.6 1.2e-09 38.4 0.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF38510.1 - 3.4e-06 26.8 0.0 6.4e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family PepX_C PF08530.5 CCF38510.1 - 0.012 15.5 0.1 0.03 14.2 0.0 1.7 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Hydrolase_4 PF12146.3 CCF38510.1 - 0.05 13.4 0.2 0.16 11.7 0.0 1.9 2 0 0 2 2 2 0 Putative lysophospholipase IN_DBD_C PF00552.16 CCF38510.1 - 0.067 12.6 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 Integrase DNA binding domain FAD_binding_3 PF01494.14 CCF38511.1 - 0.00033 19.8 0.2 0.00095 18.3 0.1 1.6 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF38511.1 - 0.0052 15.7 2.0 0.18 10.6 1.1 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF38511.1 - 0.0068 16.4 0.7 0.0068 16.4 0.5 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF38511.1 - 0.019 14.8 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF38511.1 - 0.12 11.0 1.5 8.6 4.8 1.3 2.1 2 0 0 2 2 2 0 Tryptophan halogenase FAD_binding_2 PF00890.19 CCF38511.1 - 0.46 9.2 4.0 1 8.1 2.6 1.6 2 0 0 2 2 2 0 FAD binding domain FMN_dh PF01070.13 CCF38512.1 - 4.6e-119 397.4 0.1 5.7e-119 397.1 0.1 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.12 CCF38512.1 - 3.8e-07 29.3 0.0 6.7e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.20 CCF38512.1 - 0.00033 19.6 0.6 0.0026 16.7 0.1 2.1 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.10 CCF38512.1 - 0.0036 16.5 0.4 0.0059 15.8 0.3 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.16 CCF38512.1 - 0.0046 16.2 1.2 0.42 9.8 0.1 2.3 1 1 0 2 2 2 2 Histidine biosynthesis protein ThiG PF05690.9 CCF38512.1 - 0.044 12.8 0.3 5.1 6.1 0.0 2.2 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG DUF561 PF04481.7 CCF38512.1 - 0.1 11.4 0.2 1 8.2 0.0 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF561) DUF1929 PF09118.6 CCF38514.1 - 2.9e-23 81.7 0.0 6.6e-23 80.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_6 PF13964.1 CCF38514.1 - 9e-14 50.9 0.1 0.0019 18.3 0.0 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.20 CCF38514.1 - 1.7e-13 49.8 0.0 0.0004 19.8 0.2 4.4 4 0 0 4 4 4 3 Kelch motif PAN_1 PF00024.21 CCF38514.1 - 1.8e-13 50.0 5.7 7.4e-07 28.8 0.8 2.5 2 0 0 2 2 2 2 PAN domain Kelch_4 PF13418.1 CCF38514.1 - 1.8e-13 49.9 2.8 0.0031 17.2 0.0 5.1 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.10 CCF38514.1 - 3.7e-09 35.9 0.0 0.021 14.5 0.0 4.9 4 1 0 4 4 4 2 Kelch motif PAN_4 PF14295.1 CCF38514.1 - 1.3e-05 24.8 8.6 0.028 14.1 0.9 2.8 2 0 0 2 2 2 2 PAN domain Glyoxal_oxid_N PF07250.6 CCF38514.1 - 1.3e-05 24.3 0.1 0.093 11.7 0.0 2.7 2 1 0 2 2 2 2 Glyoxal oxidase N-terminus Kelch_3 PF13415.1 CCF38514.1 - 2.1e-05 24.5 0.2 0.82 9.9 0.0 3.9 3 0 0 3 3 3 1 Galactose oxidase, central domain MANEC PF07502.9 CCF38514.1 - 0.012 15.6 7.7 0.62 10.1 0.8 2.4 2 0 0 2 2 2 0 MANEC domain Ras PF00071.17 CCF38515.1 - 6.4e-40 136.1 0.0 1.2e-37 128.8 0.0 2.1 2 0 0 2 2 2 2 Ras family Miro PF08477.8 CCF38515.1 - 7.9e-18 65.0 0.0 1.1e-17 64.6 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CCF38515.1 - 3.9e-11 42.5 0.0 6.2e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 CCF38515.1 - 0.00011 22.1 0.0 0.00019 21.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 CCF38515.1 - 0.0051 16.0 0.0 0.0074 15.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 CCF38515.1 - 0.016 14.3 0.0 0.023 13.8 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF2411 PF10304.4 CCF38515.1 - 0.065 12.8 0.3 0.13 11.8 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2411) Sec63 PF02889.11 CCF38516.1 - 3.9e-55 187.2 0.0 5.3e-55 186.8 0.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain Helicase_C PF00271.26 CCF38516.1 - 3.3e-08 33.2 0.0 1.8e-07 30.9 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF1071 PF06378.6 CCF38516.1 - 0.05 12.7 0.0 0.13 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1071) Fungal_trans PF04082.13 CCF38518.1 - 1.3e-29 102.9 0.2 1.7e-29 102.4 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF38518.1 - 3.3e-11 42.9 8.3 5.6e-11 42.1 5.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mito_carr PF00153.22 CCF38519.1 - 2.5e-57 190.5 6.3 6.3e-19 67.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein ResB PF05140.9 CCF38519.1 - 0.046 12.2 0.0 0.064 11.8 0.0 1.2 1 0 0 1 1 1 0 ResB-like family MFS_1 PF07690.11 CCF38520.1 - 6.3e-35 120.5 25.4 9e-35 120.0 17.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4231 PF14015.1 CCF38520.1 - 3.6 7.5 5.4 17 5.4 0.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) HET PF06985.6 CCF38521.1 - 1.6e-19 70.4 4.8 4.3e-17 62.5 0.1 2.5 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Zn_clus PF00172.13 CCF38522.1 - 4.9e-07 29.5 13.3 9.3e-07 28.6 9.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GFO_IDH_MocA PF01408.17 CCF38523.1 - 5.6e-15 55.9 0.0 1.1e-14 54.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold ADH_zinc_N PF00107.21 CCF38523.1 - 0.044 13.3 0.1 0.087 12.3 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase GATase PF00117.23 CCF38524.1 - 0.014 14.8 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferase class-I Nucleopor_Nup85 PF07575.8 CCF38526.1 - 1.5e-10 39.9 0.4 0.0001 20.6 0.3 3.8 2 1 0 2 2 2 2 Nup85 Nucleoporin Annexin PF00191.15 CCF38527.1 - 2.5e-70 232.3 6.8 2.7e-21 75.2 0.0 4.6 4 1 0 4 4 4 4 Annexin DUF3574 PF12098.3 CCF38527.1 - 0.0094 15.5 1.4 16 5.1 0.0 3.6 4 0 0 4 4 4 2 Protein of unknown function (DUF3574) Acetyltransf_11 PF13720.1 CCF38527.1 - 0.028 14.6 1.7 20 5.5 0.0 3.8 4 0 0 4 4 4 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 NUDIX PF00293.23 CCF38528.1 - 4.2e-15 55.5 0.1 5.6e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain SPX PF03105.14 CCF38529.1 - 3.7e-27 95.7 0.4 6e-27 95.1 0.3 1.3 1 0 0 1 1 1 1 SPX domain zf-C3HC4 PF00097.20 CCF38529.1 - 1.6e-08 34.0 10.4 2.8e-08 33.2 7.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CCF38529.1 - 1.7e-08 34.1 8.9 3.2e-08 33.2 6.2 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 CCF38529.1 - 1.4e-07 31.3 12.1 2.8e-07 30.4 8.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF38529.1 - 1.7e-06 27.5 9.0 3.1e-06 26.7 6.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF38529.1 - 3e-06 26.9 11.0 6.6e-06 25.8 7.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 CCF38529.1 - 3.1e-05 23.6 9.2 6e-05 22.6 6.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 CCF38529.1 - 0.00018 21.1 7.4 0.00053 19.6 5.1 1.9 1 0 0 1 1 1 1 RING-type zinc-finger TerY-C PF15616.1 CCF38529.1 - 0.015 15.2 1.8 0.015 15.2 1.2 1.7 2 0 0 2 2 2 0 TerY-C metal binding domain zf-RING_4 PF14570.1 CCF38529.1 - 0.016 14.7 4.7 0.016 14.7 3.2 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.1 CCF38529.1 - 0.044 13.5 3.0 0.11 12.3 2.0 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Apc11 PF12861.2 CCF38529.1 - 0.067 13.0 2.6 0.14 12.0 1.8 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 CCF38529.1 - 0.076 13.1 7.9 0.2 11.8 5.4 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger Cys_Met_Meta_PP PF01053.15 CCF38530.1 - 6.5e-37 126.7 0.0 8.9e-37 126.2 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 CCF38530.1 - 0.04 12.8 0.0 0.066 12.1 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Bestrophin PF01062.16 CCF38532.1 - 3.4e-48 164.1 2.4 1.2e-45 155.7 1.7 2.1 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel VIT1 PF01988.14 CCF38532.1 - 0.039 13.4 0.6 0.086 12.3 0.0 1.7 2 0 0 2 2 2 0 VIT family p450 PF00067.17 CCF38534.1 - 1.1e-39 136.2 0.0 1.6e-39 135.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Aldedh PF00171.17 CCF38535.1 - 1.5e-152 508.2 0.0 1.6e-152 508.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PTR2 PF00854.16 CCF38536.1 - 1.4e-32 112.9 7.2 1.4e-32 112.9 5.0 2.2 1 1 1 2 2 2 2 POT family DUF1469 PF07332.6 CCF38536.1 - 0.011 15.3 0.2 0.011 15.3 0.2 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF1469) Herpes_US9 PF06072.6 CCF38536.1 - 1 9.2 5.9 5.6 6.8 0.0 3.2 3 0 0 3 3 3 0 Alphaherpesvirus tegument protein US9 Nse5 PF08691.5 CCF38541.1 - 0.1 11.0 0.0 0.13 10.7 0.0 1.0 1 0 0 1 1 1 0 DNA repair proteins Nse5 and Nse6 OPT PF03169.10 CCF38542.1 - 1.3e-65 222.0 19.3 1.8e-65 221.6 13.4 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF3328 PF11807.3 CCF38543.1 - 1.9e-52 178.0 2.3 2.6e-52 177.6 1.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Ssu72 PF04722.8 CCF38544.1 - 1.4e-84 282.3 0.0 1.6e-84 282.0 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein zf-C2H2 PF00096.21 CCF38546.1 - 3.3e-10 39.7 16.5 3.5e-05 23.9 2.7 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 CCF38546.1 - 9.7e-08 31.6 10.4 0.0011 18.8 1.2 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CCF38546.1 - 1.3e-05 25.1 12.2 0.00023 21.2 2.4 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.3 CCF38546.1 - 6.9e-05 22.8 5.6 0.061 13.4 1.4 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 CCF38546.1 - 7.1e-05 22.8 16.1 0.015 15.5 2.5 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_5 PF13909.1 CCF38546.1 - 0.06 13.5 12.0 0.12 12.6 2.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2HC_2 PF13913.1 CCF38546.1 - 0.22 11.2 8.4 0.45 10.2 0.4 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-met PF12874.2 CCF38546.1 - 0.25 11.5 11.0 1.2 9.4 1.1 2.8 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 CCF38546.1 - 0.25 11.4 7.2 4 7.5 0.6 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF2256 PF10013.4 CCF38546.1 - 0.32 10.7 2.6 8.9 6.1 0.3 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) RRN7 PF11781.3 CCF38546.1 - 0.58 9.7 2.7 7.8 6.0 0.2 2.3 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 SprT-like PF10263.4 CCF38546.1 - 1.2 8.7 5.3 0.15 11.7 0.9 1.5 2 0 0 2 2 2 0 SprT-like family Folliculin PF11704.3 CCF38548.1 - 1.7e-27 96.0 0.0 5.5e-27 94.4 0.0 1.9 1 1 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport Actino_peptide PF14408.1 CCF38548.1 - 0.02 14.8 3.3 0.077 12.9 1.5 2.5 2 0 0 2 2 2 0 Ribosomally synthesized peptide in actinomycetes CAP_GLY PF01302.20 CCF38550.1 - 0.049 13.3 0.0 0.2 11.3 0.0 2.0 2 0 0 2 2 2 0 CAP-Gly domain DOPA_dioxygen PF08883.6 CCF38551.1 - 6.1e-33 113.0 0.2 3.9e-32 110.4 0.1 1.9 1 1 0 1 1 1 1 Dopa 4,5-dioxygenase family BHD_3 PF10405.4 CCF38552.1 - 3.3e-23 81.1 0.2 5.5e-23 80.4 0.1 1.4 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.4 CCF38552.1 - 4.9e-21 74.0 0.0 1.4e-20 72.5 0.0 1.8 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 CCF38552.1 - 6.6e-10 39.1 0.7 1.8e-09 37.7 0.0 2.2 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 Rad4 PF03835.10 CCF38552.1 - 0.0034 16.7 1.9 0.27 10.6 0.1 2.6 1 1 1 2 2 2 2 Rad4 transglutaminase-like domain Transglut_core PF01841.14 CCF38552.1 - 0.024 14.8 0.1 0.083 13.1 0.0 1.9 2 0 0 2 2 2 0 Transglutaminase-like superfamily FAM176 PF14851.1 CCF38552.1 - 0.2 11.3 2.6 0.48 10.1 1.8 1.6 1 0 0 1 1 1 0 FAM176 family Astro_capsid PF03115.9 CCF38552.1 - 0.8 7.8 3.8 1.1 7.4 2.6 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor UBA PF00627.26 CCF38553.1 - 0.0047 16.7 0.3 0.0088 15.8 0.2 1.5 1 0 0 1 1 1 1 UBA/TS-N domain Epimerase PF01370.16 CCF38555.1 - 3e-06 26.8 0.1 3e-06 26.8 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF38555.1 - 3.7e-05 22.5 0.1 3.7e-05 22.5 0.1 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 CCF38555.1 - 0.00049 20.0 0.1 0.00049 20.0 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.7 CCF38555.1 - 0.0016 17.3 0.1 0.0016 17.3 0.1 1.1 1 0 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 CCF38555.1 - 0.003 17.6 0.0 0.003 17.6 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF38555.1 - 0.0049 16.1 0.1 0.0049 16.1 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.12 CCF38555.1 - 0.0072 15.2 0.0 0.0072 15.2 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain UDPG_MGDP_dh_N PF03721.9 CCF38555.1 - 0.039 13.3 0.1 0.041 13.2 0.1 1.1 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain KR PF08659.5 CCF38555.1 - 0.055 13.1 0.2 0.055 13.1 0.1 1.1 1 0 0 1 1 1 0 KR domain ELFV_dehydrog PF00208.16 CCF38555.1 - 0.082 12.4 0.1 0.083 12.4 0.0 1.0 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 3HCDH_N PF02737.13 CCF38555.1 - 0.091 12.4 0.1 0.091 12.4 0.0 1.1 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DegT_DnrJ_EryC1 PF01041.12 CCF38555.1 - 0.14 11.1 0.1 0.16 10.9 0.0 1.0 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family UDPG_MGDP_dh_N PF03721.9 CCF38556.1 - 1.6e-46 158.0 0.0 2.6e-46 157.3 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.14 CCF38556.1 - 5.1e-26 90.7 0.0 1e-25 89.7 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.10 CCF38556.1 - 8.1e-21 74.1 0.0 2.2e-17 63.1 0.0 2.8 3 0 0 3 3 3 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_Gly3P_dh_N PF01210.18 CCF38556.1 - 0.059 13.0 0.0 5.2 6.7 0.0 2.6 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Peptidase_S8 PF00082.17 CCF38557.1 - 9.6e-17 61.0 0.0 1.4e-16 60.5 0.0 1.1 1 0 0 1 1 1 1 Subtilase family MFS_1 PF07690.11 CCF38558.1 - 2e-25 89.2 27.3 3.6e-25 88.4 18.6 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily WBS28 PF15164.1 CCF38558.1 - 0.014 14.4 0.6 2.5 7.1 0.2 2.2 2 0 0 2 2 2 0 Williams-Beuren syndrome chromosomal region 28 protein homologue OTT_1508_deam PF14441.1 CCF38559.1 - 4.4e-09 36.2 0.1 8.4e-09 35.3 0.1 1.5 1 0 0 1 1 1 1 OTT_1508-like deaminase Ric8 PF10165.4 CCF38559.1 - 0.026 13.3 0.4 0.036 12.8 0.3 1.2 1 0 0 1 1 1 0 Guanine nucleotide exchange factor synembryn Pectinesterase PF01095.14 CCF38560.1 - 3.2e-51 173.6 8.7 4e-51 173.3 6.0 1.0 1 0 0 1 1 1 1 Pectinesterase E1-E2_ATPase PF00122.15 CCF38563.1 - 1.2e-42 145.5 2.6 2.4e-42 144.5 1.8 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CCF38563.1 - 7.3e-35 120.1 5.7 7.3e-35 120.1 3.9 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CCF38563.1 - 2.9e-29 103.0 0.1 1.1e-23 84.7 0.0 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF38563.1 - 3.3e-19 68.6 0.0 7.8e-19 67.4 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 CCF38563.1 - 4.5e-11 43.2 0.0 1.3e-10 41.7 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CCF38563.1 - 1.5e-06 28.0 0.5 0.00024 20.7 0.4 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase cwf18 PF08315.7 CCF38566.1 - 1.6e-43 148.2 3.8 1.6e-43 148.2 2.6 1.7 2 0 0 2 2 2 1 cwf18 pre-mRNA splicing factor Pam16 PF03656.8 CCF38566.1 - 0.11 12.3 3.3 0.13 12.0 1.1 1.9 1 1 1 2 2 2 0 Pam16 PPR_2 PF13041.1 CCF38568.1 - 6.4e-08 32.4 0.0 1.4e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 PPR repeat family PPR PF01535.15 CCF38568.1 - 5.1e-06 26.1 0.0 1e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 PPR repeat PPR_3 PF13812.1 CCF38568.1 - 1e-05 25.4 0.0 2.5e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Pentatricopeptide repeat domain PPR_1 PF12854.2 CCF38568.1 - 3.8e-05 23.0 0.0 0.00018 20.9 0.0 2.1 2 0 0 2 2 2 1 PPR repeat NatB_MDM20 PF09797.4 CCF38569.1 - 6.8e-48 163.2 0.0 1.2e-47 162.4 0.0 1.3 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit zf-C4pol PF14260.1 CCF38569.1 - 1.7 8.6 6.7 2.8 7.9 2.1 2.7 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta Ilm1 PF10311.4 CCF38570.1 - 8.8e-55 184.6 0.4 1e-54 184.4 0.3 1.0 1 0 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 DPBB_1 PF03330.13 CCF38573.1 - 1.1e-09 38.1 0.1 4.8e-09 36.0 0.0 2.1 2 1 0 2 2 2 1 Rare lipoprotein A (RlpA)-like double-psi beta-barrel Barwin PF00967.12 CCF38573.1 - 4e-05 23.2 0.2 7.6e-05 22.3 0.2 1.4 1 0 0 1 1 1 1 Barwin family Hpt PF01627.18 CCF38574.1 - 6.5e-15 54.9 0.1 9.1e-15 54.4 0.1 1.2 1 0 0 1 1 1 1 Hpt domain NusB PF01029.13 CCF38574.1 - 0.046 13.6 0.1 0.17 11.8 0.0 1.8 2 0 0 2 2 2 0 NusB family AKAP7_NLS PF10469.4 CCF38576.1 - 1.1e-30 106.9 0.0 1.4e-30 106.6 0.0 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain DUF605 PF04652.11 CCF38577.1 - 0.39 10.0 8.8 0.42 9.9 6.1 1.1 1 0 0 1 1 1 0 Vta1 like Gti1_Pac2 PF09729.4 CCF38578.1 - 4.6e-59 199.0 0.0 7e-59 198.4 0.0 1.3 1 0 0 1 1 1 1 Gti1/Pac2 family CDP-OH_P_transf PF01066.16 CCF38579.1 - 8.8e-18 64.4 4.0 8.8e-18 64.4 2.8 1.6 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Abhydrolase_6 PF12697.2 CCF38581.1 - 1e-18 68.0 0.0 1.5e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF38581.1 - 4e-12 46.1 0.1 1.3e-11 44.4 0.1 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CCF38581.1 - 0.00011 21.9 0.0 0.00034 20.4 0.0 1.8 1 1 0 1 1 1 1 Putative lysophospholipase Lipase_3 PF01764.20 CCF38581.1 - 0.032 13.8 0.0 0.19 11.3 0.0 2.0 2 0 0 2 2 2 0 Lipase (class 3) MFS_1 PF07690.11 CCF38583.1 - 6.7e-06 25.0 4.9 8.9e-06 24.6 3.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF38583.1 - 0.00083 18.0 0.0 0.0011 17.6 0.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Ebola_NP PF05505.7 CCF38584.1 - 0.18 9.8 0.0 0.25 9.3 0.0 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein SWI-SNF_Ssr4 PF08549.5 CCF38585.1 - 1.4e-71 241.7 2.9 1.8e-71 241.4 2.0 1.0 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1750) 6PGD PF00393.14 CCF38586.1 - 4.4e-135 449.5 0.0 7.1e-135 448.8 0.0 1.3 2 0 0 2 2 2 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 CCF38586.1 - 3.2e-50 170.1 0.0 5.1e-50 169.4 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DNA_pol3_beta PF00712.14 CCF38586.1 - 0.02 14.7 0.0 0.05 13.4 0.0 1.6 1 0 0 1 1 1 0 DNA polymerase III beta subunit, N-terminal domain PGK PF00162.14 CCF38586.1 - 0.051 12.1 0.0 0.09 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphoglycerate kinase NAD_binding_11 PF14833.1 CCF38586.1 - 0.056 13.4 0.0 0.22 11.5 0.0 2.0 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase RRM_1 PF00076.17 CCF38587.1 - 4.1e-17 61.5 0.0 7.2e-17 60.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF38587.1 - 5.5e-12 45.4 0.0 9.7e-12 44.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF38587.1 - 0.00028 20.6 0.0 0.00046 19.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.6 CCF38587.1 - 0.11 12.0 0.2 0.22 11.0 0.2 1.4 1 0 0 1 1 1 0 Ribonuclease B OB domain TPT PF03151.11 CCF38588.1 - 1.3e-31 109.3 12.1 1.3e-31 109.3 8.4 2.3 2 0 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 CCF38588.1 - 2.1e-05 23.6 17.5 2.1e-05 23.6 12.2 1.5 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 CCF38588.1 - 0.00094 19.2 34.6 0.0053 16.8 5.4 2.9 2 1 0 2 2 2 2 EamA-like transporter family CD99L2 PF12301.3 CCF38588.1 - 0.003 17.2 0.9 0.0075 15.9 0.6 1.6 1 0 0 1 1 1 1 CD99 antigen like protein 2 Slx4 PF09494.5 CCF38590.1 - 1.2e-18 66.5 0.1 1.4e-18 66.3 0.1 1.0 1 0 0 1 1 1 1 Slx4 endonuclease NUDIX PF00293.23 CCF38591.1 - 1.2e-12 47.6 0.0 3.8e-11 42.7 0.0 2.4 1 1 0 1 1 1 1 NUDIX domain Nop14 PF04147.7 CCF38592.1 - 0.084 10.7 2.5 0.098 10.5 1.7 1.1 1 0 0 1 1 1 0 Nop14-like family Sporozoite_P67 PF05642.6 CCF38592.1 - 0.56 8.0 5.7 0.9 7.3 4.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen BUD22 PF09073.5 CCF38592.1 - 1.9 7.4 8.2 2.7 6.9 5.7 1.3 1 0 0 1 1 1 0 BUD22 Zn_clus PF00172.13 CCF38593.1 - 3.3e-07 30.1 10.3 5e-07 29.5 7.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NAM-associated PF14303.1 CCF38593.1 - 0.02 15.2 2.2 0.026 14.8 1.5 1.1 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Aldedh PF00171.17 CCF38595.1 - 1.1e-120 403.1 3.1 1.4e-120 402.8 2.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 CCF38595.1 - 0.00019 20.2 0.0 0.00041 19.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) Pex14_N PF04695.8 CCF38596.1 - 0.038 14.0 0.2 0.1 12.6 0.1 1.7 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SecE PF00584.15 CCF38596.1 - 0.048 13.2 4.8 0.39 10.3 0.0 2.1 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex PepSY_TM PF03929.11 CCF38596.1 - 1.2 9.6 5.6 0.95 9.9 0.2 2.2 2 0 0 2 2 2 0 PepSY-associated TM helix GST_N_2 PF13409.1 CCF38597.1 - 2.8e-07 30.4 0.0 5.3e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 CCF38597.1 - 7.2e-07 29.3 0.0 1.5e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 CCF38597.1 - 1.3e-05 24.9 0.5 3e-05 23.8 0.3 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 CCF38597.1 - 0.048 14.1 0.1 0.087 13.3 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Sugar_tr PF00083.19 CCF38598.1 - 3.6e-74 249.9 25.5 4.3e-74 249.7 17.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF38598.1 - 3.5e-19 68.7 29.2 3.5e-19 68.7 20.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.13 CCF38599.1 - 5.1e-29 100.9 0.0 7.6e-29 100.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DEAD PF00270.24 CCF38600.1 - 6.6e-46 155.8 0.0 1.5e-45 154.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF38600.1 - 3.8e-23 81.1 0.0 5.8e-22 77.3 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.7 CCF38600.1 - 2.7e-22 78.3 4.2 2.7e-22 78.3 2.9 2.2 2 0 0 2 2 2 1 DBP10CT (NUC160) domain ResIII PF04851.10 CCF38600.1 - 0.0014 18.5 0.0 0.0051 16.6 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AP2 PF00847.15 CCF38600.1 - 0.037 14.1 0.6 0.037 14.1 0.4 3.1 2 0 0 2 2 2 0 AP2 domain HSP70 PF00012.15 CCF38601.1 - 2.8e-11 42.0 0.1 1.3e-08 33.2 0.0 2.1 2 0 0 2 2 2 2 Hsp70 protein Tropomyosin PF00261.15 CCF38602.1 - 0.0072 15.4 2.1 0.013 14.5 1.4 1.4 1 0 0 1 1 1 1 Tropomyosin TBPIP PF07106.8 CCF38602.1 - 0.061 12.8 0.6 0.14 11.6 0.3 1.6 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) WEMBL PF05701.6 CCF38602.1 - 0.1 11.0 4.9 0.15 10.4 3.4 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Smr PF01713.16 CCF38604.1 - 1.7e-10 40.9 0.3 4.5e-10 39.5 0.2 1.8 1 0 0 1 1 1 1 Smr domain CUE PF02845.11 CCF38604.1 - 5.8e-05 22.4 0.2 0.034 13.6 0.2 2.7 2 0 0 2 2 2 2 CUE domain Glyco_transf_34 PF05637.7 CCF38605.1 - 5.5e-65 219.1 1.5 8.6e-65 218.5 1.0 1.3 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Glyco_hydro_16 PF00722.16 CCF38606.1 - 3.6e-10 39.4 0.0 1.1e-09 37.8 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 Adeno_shaft PF00608.12 CCF38606.1 - 0.068 12.7 0.3 0.16 11.6 0.2 1.7 1 0 0 1 1 1 0 Adenoviral fibre protein (repeat/shaft region) SNF2_N PF00176.18 CCF38608.1 - 9e-32 110.0 0.0 6.8e-31 107.1 0.0 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain DEAD PF00270.24 CCF38608.1 - 2.3e-08 33.7 0.0 3.7e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 CCF38608.1 - 0.0021 17.8 0.0 0.46 10.2 0.0 2.2 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Methyltransf_23 PF13489.1 CCF38611.1 - 0.001 18.8 0.0 0.0014 18.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain SPK PF04435.13 CCF38611.1 - 0.057 13.3 0.0 0.092 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF545) PRP21_like_P PF12230.3 CCF38615.1 - 1e-59 201.8 23.2 3.2e-59 200.2 16.1 1.8 1 1 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.15 CCF38615.1 - 7.8e-39 131.1 2.8 1.3e-19 69.5 0.1 2.4 2 0 0 2 2 2 2 Surp module NinF PF05810.7 CCF38615.1 - 0.0029 17.3 0.3 0.0083 15.9 0.2 1.7 1 0 0 1 1 1 1 NinF protein Ribosomal_60s PF00428.14 CCF38615.1 - 3.6 8.0 15.0 7.2 7.0 0.4 3.6 3 0 0 3 3 3 0 60s Acidic ribosomal protein PMT PF02366.13 CCF38617.1 - 2.3e-07 30.4 0.1 2.7e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Tcp10_C PF07202.8 CCF38619.1 - 0.061 12.8 0.0 0.077 12.5 0.0 1.1 1 0 0 1 1 1 0 T-complex protein 10 C-terminus ArgJ PF01960.13 CCF38619.1 - 0.12 10.7 0.0 0.12 10.7 0.0 1.1 1 0 0 1 1 1 0 ArgJ family Rep_fac-A_C PF08646.5 CCF38620.1 - 6.9e-57 191.2 5.0 1.7e-55 186.7 2.5 2.5 2 0 0 2 2 2 1 Replication factor-A C terminal domain Rep-A_N PF04057.7 CCF38620.1 - 2.3e-24 85.1 0.1 7.4e-24 83.4 0.1 1.9 2 0 0 2 2 2 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.20 CCF38620.1 - 5.9e-17 61.2 1.0 3e-11 43.0 0.0 4.2 4 1 1 5 5 5 2 OB-fold nucleic acid binding domain DUF223 PF02721.9 CCF38620.1 - 0.023 14.7 0.0 0.051 13.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF223 DLH PF01738.13 CCF38621.1 - 4.2e-09 36.0 0.0 7.6e-08 31.8 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 CCF38621.1 - 7e-08 32.3 0.0 1.1e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family TPR_1 PF00515.23 CCF38622.1 - 8.6e-13 47.3 8.9 7.6e-05 22.1 0.0 4.9 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.1 CCF38622.1 - 7.4e-10 38.6 10.3 7.3e-06 25.8 0.0 4.7 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.12 CCF38622.1 - 2.8e-09 36.1 8.5 0.00011 21.8 0.0 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 CCF38622.1 - 1.3e-08 33.9 8.8 0.00062 19.3 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.1 CCF38622.1 - 8.1e-08 31.7 13.5 1.3e-06 27.9 0.1 4.0 4 0 0 4 4 4 1 TPR repeat TPR_7 PF13176.1 CCF38622.1 - 3e-07 29.7 4.9 0.0087 15.7 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 CCF38622.1 - 1.2e-05 25.5 2.9 0.00029 21.1 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 CCF38622.1 - 0.0002 21.6 0.1 0.48 11.2 0.0 4.5 3 0 0 3 3 3 1 Tetratricopeptide repeat AAA_16 PF13191.1 CCF38622.1 - 0.00083 19.3 0.0 0.011 15.7 0.0 2.9 1 1 1 2 2 2 1 AAA ATPase domain TPR_17 PF13431.1 CCF38622.1 - 0.0018 18.3 1.9 0.85 9.9 0.0 4.3 4 0 0 4 4 3 1 Tetratricopeptide repeat NACHT PF05729.7 CCF38622.1 - 0.0024 17.5 0.0 0.0065 16.1 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.1 CCF38622.1 - 0.0029 17.7 0.0 0.022 14.9 0.0 2.6 1 1 0 1 1 1 1 AAA domain TPR_16 PF13432.1 CCF38622.1 - 0.0041 17.7 0.2 0.46 11.2 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 CCF38622.1 - 0.0082 16.5 2.3 5.6 7.6 0.0 4.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_10 PF13374.1 CCF38622.1 - 0.015 15.2 1.5 32 4.6 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF2075 PF09848.4 CCF38622.1 - 0.017 14.1 0.0 0.043 12.7 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_17 PF13207.1 CCF38622.1 - 0.091 13.5 0.1 2.6 8.8 0.0 3.4 3 0 0 3 3 2 0 AAA domain AAA_18 PF13238.1 CCF38622.1 - 0.11 12.8 0.0 0.42 10.9 0.0 2.1 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 CCF38622.1 - 0.12 12.5 0.0 0.7 10.1 0.0 2.4 2 0 0 2 2 1 0 RNA helicase FAA_hydrolase PF01557.13 CCF38623.1 - 2.9e-52 177.2 0.0 4.3e-52 176.7 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family B12-binding PF02310.14 CCF38624.1 - 0.008 16.0 0.1 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 B12 binding domain FtsK_SpoIIIE PF01580.13 CCF38624.1 - 0.018 14.4 0.0 0.028 13.9 0.0 1.2 1 1 0 1 1 1 0 FtsK/SpoIIIE family DXP_reductoisom PF02670.11 CCF38624.1 - 0.055 14.0 0.0 0.072 13.6 0.0 1.2 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Mitofilin PF09731.4 CCF38624.1 - 0.13 10.8 0.0 0.13 10.8 0.0 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein FAD_binding_3 PF01494.14 CCF38625.1 - 8e-24 84.3 0.0 1e-23 83.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF38625.1 - 4e-15 55.5 2.7 1.8e-06 27.1 0.0 2.3 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 CCF38625.1 - 3.9e-07 30.3 0.0 0.00033 20.9 0.1 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF38625.1 - 1.1e-06 28.5 3.2 2.6e-06 27.3 0.5 2.6 3 0 0 3 3 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 CCF38625.1 - 2.6e-06 26.1 0.3 0.00028 19.4 0.4 2.1 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.9 CCF38625.1 - 8.4e-06 25.7 0.0 2e-05 24.5 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF38625.1 - 1e-05 24.5 1.6 2.3e-05 23.4 1.1 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.1 CCF38625.1 - 0.00019 21.5 0.0 0.00047 20.2 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 CCF38625.1 - 0.00029 20.0 1.7 0.00044 19.4 1.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 CCF38625.1 - 0.00057 19.0 0.1 0.00087 18.4 0.1 1.2 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.17 CCF38625.1 - 0.00089 18.2 0.5 0.0014 17.5 0.3 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Lycopene_cycl PF05834.7 CCF38625.1 - 0.0041 16.0 0.2 0.0095 14.8 0.1 1.5 1 1 0 1 1 1 1 Lycopene cyclase protein 3HCDH_N PF02737.13 CCF38625.1 - 0.0055 16.3 0.2 0.01 15.4 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Trp_halogenase PF04820.9 CCF38625.1 - 0.012 14.3 0.5 0.053 12.1 0.1 1.9 1 1 1 2 2 2 0 Tryptophan halogenase Amino_oxidase PF01593.19 CCF38625.1 - 0.031 13.3 0.4 1.4 7.9 0.0 2.8 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase SE PF08491.5 CCF38625.1 - 0.074 11.8 0.0 0.18 10.5 0.0 1.7 1 1 0 1 1 1 0 Squalene epoxidase UDPG_MGDP_dh_N PF03721.9 CCF38625.1 - 0.2 11.0 0.1 0.32 10.3 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF2688 PF10892.3 CCF38626.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2688) LON PF02190.11 CCF38627.1 - 2.3e-27 96.0 0.0 3.2e-27 95.5 0.0 1.2 1 0 0 1 1 1 1 ATP-dependent protease La (LON) domain zf-C3HC4_4 PF15227.1 CCF38627.1 - 4.7e-11 42.3 18.9 4.1e-06 26.5 5.3 2.8 2 1 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 CCF38627.1 - 6.7e-11 42.0 24.9 7.9e-08 32.2 7.3 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF38627.1 - 1.2e-09 37.8 22.9 1.5e-07 31.1 8.0 2.7 2 0 0 2 2 2 2 Ring finger domain zf-RING_5 PF14634.1 CCF38627.1 - 1.9e-09 37.0 22.0 1.1e-06 28.1 6.4 2.4 2 0 0 2 2 2 2 zinc-RING finger domain zf-C3HC4_3 PF13920.1 CCF38627.1 - 3e-09 36.3 18.6 6.2e-08 32.1 4.6 2.4 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF38627.1 - 1.9e-08 33.8 18.3 1.5e-06 27.7 6.3 2.5 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 CCF38627.1 - 6.1e-06 25.8 13.3 1.1e-05 25.0 0.7 3.3 2 1 1 3 3 3 1 RING-type zinc-finger zf-RING_4 PF14570.1 CCF38627.1 - 0.00029 20.3 2.0 0.00029 20.3 1.4 2.9 2 1 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.2 CCF38627.1 - 0.0032 17.5 3.9 0.0094 16.0 2.7 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger zf-P11 PF03854.9 CCF38627.1 - 0.004 16.5 5.8 0.004 16.5 4.0 2.3 3 0 0 3 3 3 1 P-11 zinc finger U-box PF04564.10 CCF38627.1 - 0.0083 16.0 0.0 0.094 12.6 0.0 2.4 2 0 0 2 2 2 1 U-box domain zf-RING_6 PF14835.1 CCF38627.1 - 0.7 9.7 14.6 3 7.6 1.3 2.5 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Med2 PF11214.3 CCF38629.1 - 0.0093 15.9 0.1 0.021 14.8 0.0 1.5 1 0 0 1 1 1 1 Mediator complex subunit 2 Syntaxin-6_N PF09177.6 CCF38629.1 - 0.093 13.1 0.2 0.17 12.3 0.1 1.4 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Rad60-SLD PF11976.3 CCF38631.1 - 1.2e-20 72.9 0.0 3.3e-20 71.5 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 CCF38631.1 - 1.3e-05 24.4 0.0 2.8e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family LSM PF01423.17 CCF38632.1 - 3e-20 71.5 0.0 3.5e-20 71.3 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 CCF38632.1 - 0.00013 21.7 0.1 0.00016 21.5 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.2 CCF38632.1 - 0.099 12.4 0.1 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 Scd6-like Sm domain SpoA PF01052.15 CCF38632.1 - 0.12 11.9 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Surface presentation of antigens (SPOA) Abhydrolase_6 PF12697.2 CCF38634.1 - 4e-20 72.6 0.0 4.8e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF38634.1 - 8.2e-16 58.2 0.0 1.5e-15 57.3 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF38634.1 - 2.3e-10 40.4 0.0 3.8e-10 39.7 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 CCF38634.1 - 0.00012 21.5 0.4 3.6 6.9 0.1 4.0 2 1 1 4 4 4 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.3 CCF38634.1 - 0.0017 18.1 0.0 0.0041 16.9 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase AXE1 PF05448.7 CCF38634.1 - 0.0031 16.0 0.3 2.9 6.3 0.0 3.0 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Ndr PF03096.9 CCF38634.1 - 0.0055 15.2 0.1 0.008 14.6 0.1 1.4 1 1 0 1 1 1 1 Ndr family Peptidase_S15 PF02129.13 CCF38634.1 - 0.0091 15.4 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_4 PF08386.5 CCF38634.1 - 0.077 12.9 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 TAP-like protein Cu-oxidase_3 PF07732.10 CCF38635.1 - 1.5e-39 134.3 2.5 1.5e-39 134.3 1.7 2.4 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.17 CCF38635.1 - 4.2e-36 124.2 0.0 1.2e-35 122.7 0.0 1.8 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 CCF38635.1 - 7.4e-36 122.6 1.5 7.4e-36 122.6 1.0 3.0 2 1 0 2 2 2 1 Multicopper oxidase PAN_1 PF00024.21 CCF38636.1 - 1.9e-05 24.3 0.6 2.5e-05 23.9 0.4 1.3 1 1 0 1 1 1 1 PAN domain PAN_3 PF08277.7 CCF38636.1 - 0.0026 17.3 0.7 0.0034 16.9 0.4 1.5 1 1 0 1 1 1 1 PAN-like domain PAN_4 PF14295.1 CCF38636.1 - 0.023 14.4 5.5 0.043 13.5 3.8 1.7 1 1 0 1 1 1 0 PAN domain Oxidored_q6 PF01058.17 CCF38636.1 - 0.072 12.6 0.7 0.085 12.4 0.5 1.2 1 0 0 1 1 1 0 NADH ubiquinone oxidoreductase, 20 Kd subunit Cmc1 PF08583.5 CCF38636.1 - 0.46 10.3 3.3 0.21 11.3 0.7 1.7 2 0 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like MFS_1 PF07690.11 CCF38640.1 - 2.3e-27 95.6 68.6 2.2e-21 76.0 29.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily YrvL PF14184.1 CCF38640.1 - 0.025 14.3 4.7 0.052 13.3 3.2 1.5 1 0 0 1 1 1 0 Regulatory protein YrvL PAN_4 PF14295.1 CCF38641.1 - 0.0097 15.6 1.3 0.0097 15.6 0.9 2.4 3 0 0 3 3 3 1 PAN domain Mucin PF01456.12 CCF38641.1 - 4 7.1 55.4 4.7 6.9 15.1 2.6 2 0 0 2 2 2 0 Mucin-like glycoprotein Ferric_reduct PF01794.14 CCF38642.1 - 8.9e-21 74.2 12.4 9.4e-21 74.1 6.7 2.2 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 CCF38642.1 - 1.8e-08 34.2 0.0 1.3e-07 31.3 0.0 2.2 1 1 0 1 1 1 1 FAD-binding domain SAC3_GANP PF03399.11 CCF38643.1 - 1.9e-28 99.4 0.0 2.7e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family LTV PF04180.9 CCF38644.1 - 5.7e-107 358.8 11.5 6.5e-107 358.6 7.9 1.0 1 0 0 1 1 1 1 Low temperature viability protein Polysacc_synt_4 PF04669.8 CCF38644.1 - 0.1 11.9 0.1 0.19 11.1 0.1 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis PBP PF01161.15 CCF38646.1 - 1.5e-14 54.0 0.0 2e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Pyr_redox_2 PF07992.9 CCF38647.1 - 5.1e-15 55.8 4.0 2.7e-13 50.2 2.7 3.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF38647.1 - 1.6e-10 41.3 4.9 3.2e-05 24.0 0.3 3.1 1 1 2 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF38647.1 - 2.6e-10 40.5 0.3 3.6e-09 36.9 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF38647.1 - 2.2e-06 27.5 0.8 0.72 9.6 0.0 3.4 3 0 0 3 3 3 3 FAD-NAD(P)-binding DAO PF01266.19 CCF38647.1 - 5.3e-05 22.2 8.0 0.16 10.8 0.1 3.7 3 1 0 4 4 4 2 FAD dependent oxidoreductase K_oxygenase PF13434.1 CCF38647.1 - 9.5e-05 21.4 1.0 0.061 12.2 0.1 2.7 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.9 CCF38647.1 - 0.0018 16.8 1.0 1.4 7.3 0.0 3.2 3 1 1 4 4 4 2 HI0933-like protein Lycopene_cycl PF05834.7 CCF38647.1 - 0.022 13.6 0.1 0.23 10.3 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein ATP-synt PF00231.14 CCF38647.1 - 0.12 11.6 0.1 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 ATP synthase cobW PF02492.14 CCF38649.1 - 2.7e-38 131.1 0.0 5e-38 130.3 0.0 1.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.9 CCF38649.1 - 0.0013 18.3 0.0 0.0026 17.4 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B Viral_helicase1 PF01443.13 CCF38649.1 - 0.0061 16.1 0.0 0.017 14.6 0.0 1.8 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.1 CCF38649.1 - 0.023 14.4 0.1 0.055 13.2 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain DUF2075 PF09848.4 CCF38649.1 - 0.031 13.2 0.0 0.063 12.2 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 CCF38649.1 - 0.039 14.0 0.0 0.12 12.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 CCF38649.1 - 0.046 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 CCF38649.1 - 0.057 13.1 0.1 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 NTPase AAA_29 PF13555.1 CCF38649.1 - 0.068 12.7 0.1 0.51 9.8 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_18 PF13238.1 CCF38649.1 - 0.081 13.2 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CCF38649.1 - 0.087 12.7 0.1 0.23 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_10 PF12846.2 CCF38649.1 - 0.15 11.5 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain tRNA-synt_1 PF00133.17 CCF38650.1 - 9.7e-51 172.4 0.0 1.4e-17 63.0 0.1 6.1 2 1 3 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.1 CCF38650.1 - 1.5e-41 141.7 0.0 2.8e-41 140.8 0.0 1.5 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.6 CCF38650.1 - 4.1e-31 108.0 0.1 9.6e-23 80.4 0.0 4.2 3 1 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 CCF38650.1 - 1.8e-14 53.7 0.0 3.3e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 CCF38650.1 - 0.011 14.9 0.0 4.5 6.3 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain tRNA-synt_1d PF00750.14 CCF38650.1 - 0.025 13.4 0.0 0.043 12.6 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (R) tRNA-synt_1c PF00749.16 CCF38650.1 - 0.07 11.7 0.3 4.7 5.7 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain Ank PF00023.25 CCF38651.1 - 1.3e-12 46.7 0.2 2.4e-07 30.2 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat TIG PF01833.19 CCF38651.1 - 1.6e-12 47.2 0.4 3.8e-12 46.0 0.3 1.7 1 0 0 1 1 1 1 IPT/TIG domain Ank_2 PF12796.2 CCF38651.1 - 5.8e-11 42.5 0.0 1.2e-10 41.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 CCF38651.1 - 8.6e-08 32.1 0.2 2.4e-07 30.7 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 CCF38651.1 - 1.8e-05 25.1 0.0 4.7e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF38651.1 - 3e-05 23.8 0.0 0.013 15.6 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Cyclin_N PF00134.18 CCF38652.1 - 1.3e-38 131.4 0.2 2.5e-38 130.4 0.2 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 CCF38652.1 - 4e-12 46.1 0.1 9.7e-12 44.8 0.1 1.7 1 0 0 1 1 1 1 Cyclin, C-terminal domain Ribosomal_S5 PF00333.15 CCF38653.1 - 2.7e-28 97.5 1.6 2.7e-28 97.5 1.1 1.6 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.10 CCF38653.1 - 1.1e-21 75.8 0.1 2.1e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.1 CCF38653.1 - 4.1 7.9 16.2 0.23 11.9 7.6 1.6 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 Rhodanese PF00581.15 CCF38654.1 - 6.6e-22 77.9 0.0 6e-13 49.1 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain DAP_epimerase PF01678.14 CCF38654.1 - 0.11 12.4 0.0 1.7 8.5 0.0 2.3 2 0 0 2 2 2 0 Diaminopimelate epimerase Fungal_trans PF04082.13 CCF38655.1 - 1.9e-13 49.9 0.3 4.4e-13 48.7 0.2 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 CCF38655.1 - 2.1e-11 43.4 10.2 3.5e-05 23.8 0.0 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type Zn_clus PF00172.13 CCF38655.1 - 2.5e-06 27.2 10.0 2.5e-06 27.2 7.0 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_4 PF13894.1 CCF38655.1 - 4.9e-06 26.5 20.8 8.7e-05 22.5 0.1 3.9 4 0 0 4 4 4 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CCF38655.1 - 3.9e-05 23.7 5.0 0.00055 20.1 0.1 3.5 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.3 CCF38655.1 - 0.2 11.8 8.8 1 9.6 0.1 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CCF38655.1 - 2.8 8.2 9.3 4.7 7.5 0.7 3.4 4 0 0 4 4 4 0 Zinc-finger of C2H2 type Peptidase_S8 PF00082.17 CCF38656.1 - 9.8e-25 87.2 0.0 1.4e-24 86.7 0.0 1.2 1 0 0 1 1 1 1 Subtilase family F-box-like PF12937.2 CCF38657.1 - 8.7e-06 25.3 1.1 0.00016 21.2 1.4 2.3 2 0 0 2 2 2 1 F-box-like SnoaL_2 PF12680.2 CCF38659.1 - 0.067 13.5 0.0 0.12 12.7 0.0 1.6 1 1 0 1 1 1 0 SnoaL-like domain SnoaL_4 PF13577.1 CCF38659.1 - 0.082 12.8 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 SnoaL-like domain TPR_12 PF13424.1 CCF38661.1 - 2.4e-37 126.7 33.7 2.7e-11 43.2 0.7 5.7 3 2 2 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.1 CCF38661.1 - 1.1e-30 104.5 18.0 6.1e-05 22.8 0.0 8.7 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_1 PF00515.23 CCF38661.1 - 2.6e-15 55.2 14.9 0.0091 15.5 0.1 6.9 6 1 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.12 CCF38661.1 - 3e-13 48.5 23.5 0.012 15.5 0.1 7.6 7 1 0 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.1 CCF38661.1 - 6.1e-13 47.5 18.1 0.011 15.4 0.0 7.9 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_19 PF14559.1 CCF38661.1 - 2.9e-12 46.7 19.9 0.0072 16.6 0.2 6.7 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.1 CCF38661.1 - 1.5e-11 43.7 15.7 1.1e-06 28.1 0.8 4.8 2 1 1 4 4 4 3 TPR repeat TPR_17 PF13431.1 CCF38661.1 - 3.5e-10 39.2 8.8 3.6 8.0 0.1 7.6 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.1 CCF38661.1 - 8.1e-10 39.1 21.4 0.00038 21.0 1.4 6.5 4 2 3 7 7 6 5 Tetratricopeptide repeat TPR_20 PF14561.1 CCF38661.1 - 1.3e-07 31.6 23.7 0.0063 16.5 0.3 7.4 1 1 5 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.1 CCF38661.1 - 1.5e-06 27.5 10.4 0.25 11.1 0.0 6.1 7 0 0 7 7 5 2 Tetratricopeptide repeat TPR_4 PF07721.9 CCF38661.1 - 1.8e-06 27.8 15.2 2.6 8.7 0.0 7.6 7 0 0 7 7 7 2 Tetratricopeptide repeat AAA_22 PF13401.1 CCF38661.1 - 1.4e-05 25.2 0.0 0.00041 20.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain TPR_14 PF13428.1 CCF38661.1 - 1.8e-05 24.9 19.6 1.4 9.7 0.2 7.6 5 2 2 7 7 7 1 Tetratricopeptide repeat Apc3 PF12895.2 CCF38661.1 - 0.0003 20.8 15.5 0.016 15.3 0.3 5.3 3 1 4 7 7 6 3 Anaphase-promoting complex, cyclosome, subunit 3 DUF1376 PF07120.6 CCF38661.1 - 0.0064 16.5 0.1 0.078 13.1 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1376) DUF3234 PF11572.3 CCF38661.1 - 0.018 15.1 0.7 0.093 12.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3234) Pkinase PF00069.20 CCF38662.1 - 0.0001 21.5 0.1 0.00019 20.6 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain MFS_1 PF07690.11 CCF38663.1 - 8.4e-35 120.1 12.4 4.1e-27 94.8 3.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF38663.1 - 0.011 15.5 1.2 0.16 11.7 0.5 2.6 2 0 0 2 2 2 0 MFS_1 like family GMC_oxred_N PF00732.14 CCF38664.1 - 6.9e-45 153.4 0.0 9.7e-45 152.9 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF38664.1 - 1.9e-33 115.7 0.1 5.7e-32 110.9 0.1 2.4 1 1 0 1 1 1 1 GMC oxidoreductase Peptidase_M28 PF04389.12 CCF38665.1 - 1.7e-34 119.1 0.0 2.6e-34 118.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 CCF38665.1 - 1e-16 60.4 0.1 2.1e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 PA domain Fungal_trans PF04082.13 CCF38666.1 - 1.5e-21 76.4 0.0 2.3e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF38666.1 - 1.7e-10 40.6 11.5 4e-10 39.4 8.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain APG6 PF04111.7 CCF38666.1 - 0.14 11.1 0.7 0.39 9.7 0.7 1.5 2 0 0 2 2 2 0 Autophagy protein Apg6 ZYG-11_interact PF05884.7 CCF38666.1 - 0.17 10.9 0.4 0.26 10.3 0.3 1.3 1 0 0 1 1 1 0 Interactor of ZYG-11 DivIC PF04977.10 CCF38666.1 - 0.22 11.0 3.2 0.13 11.7 0.9 1.5 1 1 0 1 1 1 0 Septum formation initiator MFS_1 PF07690.11 CCF38667.1 - 1.2e-14 53.8 51.3 1.2e-13 50.5 35.1 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF38667.1 - 1.1e-06 27.2 24.9 1.4e-06 26.7 17.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Methyltransf_23 PF13489.1 CCF38668.1 - 2.2e-06 27.4 0.0 3.7e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF38668.1 - 2.7e-06 27.9 0.1 0.00011 22.7 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.1 CCF38668.1 - 0.0023 18.7 0.0 0.006 17.3 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF38668.1 - 0.0044 16.6 0.0 0.028 14.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF38668.1 - 0.0053 17.1 0.0 0.15 12.3 0.0 2.9 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF38668.1 - 0.013 15.9 0.0 8.7 6.9 0.0 2.7 1 1 1 2 2 2 0 Methyltransferase domain PCMT PF01135.14 CCF38668.1 - 0.018 14.5 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.9 CCF38668.1 - 0.019 14.1 0.0 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB MetW PF07021.7 CCF38668.1 - 0.094 12.0 0.0 0.22 10.8 0.0 1.5 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW Fungal_trans_2 PF11951.3 CCF38669.1 - 3.5e-08 32.4 0.1 5.1e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF38669.1 - 9.8e-08 31.7 11.4 1.7e-07 30.9 7.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain eIF3_subunit PF08597.5 CCF38671.1 - 2.8e-68 230.1 21.1 3.2e-68 229.9 14.6 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit CDC27 PF09507.5 CCF38671.1 - 2.6 7.1 26.3 0.13 11.4 12.9 2.0 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 MDM31_MDM32 PF08118.6 CCF38672.1 - 1.6e-36 125.8 0.4 6.7e-36 123.8 0.3 1.7 1 1 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins DUF3825 PF12873.2 CCF38672.1 - 0.12 11.5 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3825) AMP-binding PF00501.23 CCF38673.1 - 7.4e-96 321.0 0.0 9e-96 320.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF38673.1 - 6e-14 52.7 0.0 1.5e-13 51.4 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Acetyltransf_7 PF13508.1 CCF38674.1 - 0.099 12.8 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain NmrA PF05368.8 CCF38677.1 - 9.2e-19 67.6 0.0 1.1e-18 67.3 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF38677.1 - 1.3e-11 44.8 0.4 2.2e-11 44.0 0.2 1.4 1 0 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 CCF38677.1 - 3.4e-05 23.0 0.1 5.6e-05 22.2 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase DapB_N PF01113.15 CCF38677.1 - 5.2e-05 23.1 0.1 0.00011 22.1 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_3 PF03447.11 CCF38677.1 - 0.0031 17.8 0.3 0.26 11.7 0.1 2.3 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain DXP_reductoisom PF02670.11 CCF38677.1 - 0.0086 16.6 0.4 0.034 14.7 0.2 1.9 1 1 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase Epimerase PF01370.16 CCF38677.1 - 0.018 14.4 0.0 0.043 13.2 0.0 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.19 CCF38677.1 - 0.043 14.1 0.1 0.098 12.9 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DUF3940 PF13076.1 CCF38678.1 - 0.12 11.9 0.5 0.18 11.3 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3940) Synthase_beta PF11421.3 CCF38679.1 - 0.29 11.8 2.8 0.59 10.8 2.0 1.5 1 0 0 1 1 1 0 ATP synthase F1 beta subunit GMC_oxred_N PF00732.14 CCF38680.1 - 1.7e-53 181.7 0.1 2.2e-53 181.3 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF38680.1 - 8.1e-31 107.2 0.1 1.7e-30 106.2 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 CCF38680.1 - 8.4e-09 34.7 0.1 2.9e-06 26.4 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 CCF38680.1 - 3.4e-07 30.5 0.1 0.0053 16.8 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF38680.1 - 9e-07 28.1 0.4 0.0018 17.2 0.1 2.6 3 0 0 3 3 3 2 Lycopene cyclase protein FAD_binding_2 PF00890.19 CCF38680.1 - 5.9e-06 25.3 0.2 0.00083 18.3 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.1 CCF38680.1 - 9.9e-05 22.2 0.1 0.00023 21.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF38680.1 - 0.0003 20.7 0.1 0.0019 18.1 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF38680.1 - 0.00065 18.8 0.3 0.027 13.5 0.0 2.5 3 0 0 3 3 3 1 Thi4 family FAD_binding_3 PF01494.14 CCF38680.1 - 0.0047 16.0 0.8 0.016 14.2 0.3 1.9 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.9 CCF38680.1 - 0.03 12.7 0.5 0.13 10.6 0.2 1.9 2 0 0 2 2 2 0 HI0933-like protein Trp_halogenase PF04820.9 CCF38680.1 - 0.044 12.3 0.3 0.066 11.8 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase NAD_binding_9 PF13454.1 CCF38680.1 - 0.11 12.2 0.2 0.25 11.1 0.1 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.22 CCF38680.1 - 0.14 12.6 0.9 0.36 11.2 0.6 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase p450 PF00067.17 CCF38681.1 - 1.8e-33 115.8 0.0 2e-33 115.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 APH PF01636.18 CCF38682.1 - 3.2e-19 69.6 0.3 4.9e-19 69.0 0.2 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CCF38682.1 - 3.1e-05 23.6 0.0 4.8e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.17 CCF38682.1 - 0.02 14.2 0.0 3.3 7.0 0.0 2.3 2 0 0 2 2 2 0 RIO1 family MFS_1 PF07690.11 CCF38683.1 - 1.1e-43 149.3 46.9 4.8e-43 147.2 32.5 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF38683.1 - 2.9e-11 42.2 13.1 4.4e-11 41.6 9.0 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) S1FA PF04689.8 CCF38683.1 - 0.084 12.7 2.0 0.1 12.4 0.1 2.2 2 0 0 2 2 2 0 DNA binding protein S1FA TIP120 PF08623.5 CCF38684.1 - 6.2e-64 214.6 0.1 1.3e-61 207.1 0.0 3.4 3 0 0 3 3 3 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.1 CCF38684.1 - 1.7e-13 50.6 26.3 0.13 12.5 0.1 8.9 7 2 1 8 8 8 4 HEAT repeats HEAT PF02985.17 CCF38684.1 - 1.8e-06 27.5 20.0 0.27 11.4 0.1 9.5 11 1 1 12 12 12 3 HEAT repeat Adaptin_N PF01602.15 CCF38684.1 - 2.2e-06 26.3 8.7 0.46 8.7 0.1 5.6 5 2 0 5 5 5 3 Adaptin N terminal region HEAT_EZ PF13513.1 CCF38684.1 - 0.0014 19.0 23.4 14 6.2 0.5 11.4 12 2 1 13 13 13 1 HEAT-like repeat Cnd1 PF12717.2 CCF38684.1 - 0.0016 18.3 9.7 0.89 9.3 0.0 6.0 6 1 0 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Nucleoplasmin PF03066.10 CCF38684.1 - 9.3 5.7 8.7 26 4.3 6.0 1.7 1 0 0 1 1 1 0 Nucleoplasmin CDC27 PF09507.5 CCF38685.1 - 0.0086 15.3 52.8 0.01 15.1 36.6 1.2 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 DUF4094 PF13334.1 CCF38685.1 - 0.28 11.5 0.0 0.28 11.5 0.0 3.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) E1-E2_ATPase PF00122.15 CCF38686.1 - 3.1e-21 75.4 0.0 3.1e-21 75.4 0.0 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 CCF38686.1 - 3.3e-17 63.6 0.0 1.1e-12 48.8 0.0 2.6 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.2 CCF38686.1 - 9.6e-16 58.5 0.2 2.3e-14 53.9 0.1 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF38686.1 - 8.3e-12 44.9 0.0 2.6e-11 43.3 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 CCF38686.1 - 0.0014 18.2 0.0 0.0076 15.8 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 CCF38686.1 - 0.0024 18.1 0.0 0.0055 16.9 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Mito_carr PF00153.22 CCF38687.1 - 9e-41 137.5 10.2 8.1e-17 60.7 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein BetaGal_dom2 PF10435.4 CCF38689.1 - 5.3e-60 201.9 7.1 8.5e-60 201.2 4.9 1.4 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom4_5 PF13364.1 CCF38689.1 - 1.9e-48 163.3 3.8 4.9e-27 94.3 1.5 2.6 2 0 0 2 2 2 2 Beta-galactosidase jelly roll domain BetaGal_dom3 PF13363.1 CCF38689.1 - 1.6e-19 69.0 0.1 3.8e-19 67.8 0.0 1.7 1 0 0 1 1 1 1 Beta-galactosidase, domain 3 SelB-wing_3 PF09107.6 CCF38689.1 - 0.043 13.2 0.0 0.091 12.1 0.0 1.5 1 0 0 1 1 1 0 Elongation factor SelB, winged helix SNF2_N PF00176.18 CCF38691.1 - 1.6e-72 243.8 1.8 3e-72 242.9 1.2 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.1 CCF38691.1 - 7.4e-51 171.8 20.3 7.4e-51 171.8 14.0 5.8 7 1 0 7 7 7 1 DNA-binding domain Piwi PF02171.12 CCF38692.1 - 1.4e-78 263.9 0.0 2.1e-78 263.3 0.0 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 CCF38692.1 - 8.4e-14 51.0 0.0 1.9e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 CCF38692.1 - 1.1e-13 50.2 0.7 3.2e-13 48.8 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1785) SGT1 PF07093.6 CCF38693.1 - 5.8e-140 467.4 22.3 7.3e-139 463.8 15.4 1.9 1 1 0 1 1 1 1 SGT1 protein AAA_23 PF13476.1 CCF38694.1 - 1.2e-14 55.1 21.6 2.7e-11 44.1 15.0 3.2 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 CCF38694.1 - 1.6e-10 40.6 0.1 1.6e-10 40.6 0.1 2.0 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF38694.1 - 6e-05 23.1 0.2 0.00011 22.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.1 CCF38694.1 - 8.6e-05 21.7 3.3 0.00021 20.4 2.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.1 CCF38694.1 - 0.00082 18.8 0.0 0.0021 17.5 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain WXG100 PF06013.7 CCF38694.1 - 0.0067 16.4 6.4 0.0067 16.4 4.4 3.3 4 1 1 5 5 2 1 Proteins of 100 residues with WXG AAA_13 PF13166.1 CCF38694.1 - 0.014 13.9 33.2 0.0071 14.8 12.1 3.2 2 1 1 3 3 3 0 AAA domain DUF2813 PF11398.3 CCF38694.1 - 0.014 14.4 0.0 0.014 14.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2813) Reo_sigmaC PF04582.7 CCF38694.1 - 0.027 13.6 5.9 0.029 13.5 1.1 2.6 1 1 1 2 2 2 0 Reovirus sigma C capsid protein ABC_tran PF00005.22 CCF38694.1 - 0.066 13.5 0.0 0.066 13.5 0.0 3.2 2 1 0 2 2 1 0 ABC transporter Baculo_p24 PF05073.7 CCF38694.1 - 0.067 12.7 10.2 0.2 11.2 0.4 2.6 1 1 1 2 2 2 0 Baculovirus P24 capsid protein Spc7 PF08317.6 CCF38694.1 - 0.18 10.4 34.2 0.0091 14.6 5.6 3.5 2 1 2 4 4 4 0 Spc7 kinetochore protein Atg14 PF10186.4 CCF38694.1 - 0.34 9.8 30.4 0.045 12.7 7.1 2.9 3 0 0 3 3 3 0 UV radiation resistance protein and autophagy-related subunit 14 Laminin_II PF06009.7 CCF38694.1 - 0.37 10.5 20.1 0.14 11.9 3.1 3.5 2 1 1 3 3 3 0 Laminin Domain II WEMBL PF05701.6 CCF38694.1 - 0.37 9.1 34.3 0.58 8.5 23.8 1.2 1 0 0 1 1 1 0 Weak chloroplast movement under blue light DUF745 PF05335.8 CCF38694.1 - 0.91 9.0 28.2 0.52 9.8 10.0 3.4 1 1 0 2 2 2 0 Protein of unknown function (DUF745) Occludin_ELL PF07303.8 CCF38694.1 - 1.1 10.0 19.0 3.9 8.2 1.0 3.8 2 1 1 3 3 3 0 Occludin homology domain DUF1664 PF07889.7 CCF38694.1 - 1.3 8.8 17.3 0.83 9.4 1.4 4.3 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) Rootletin PF15035.1 CCF38694.1 - 2.7 7.9 29.8 0.23 11.4 3.4 2.9 1 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion IncA PF04156.9 CCF38694.1 - 5.5 6.5 47.6 0.21 11.1 7.8 3.8 2 1 2 4 4 4 0 IncA protein Glypican PF01153.14 CCF38694.1 - 6.4 5.2 12.9 0.049 12.2 2.4 2.0 2 1 0 2 2 2 0 Glypican Zn_clus PF00172.13 CCF38695.1 - 6.5e-09 35.5 4.9 9.2e-09 35.0 3.4 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cu_amine_oxid PF01179.15 CCF38696.1 - 6.7e-109 364.3 5.9 8e-109 364.0 4.1 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain DUF1965 PF09248.5 CCF38696.1 - 2.7e-33 113.6 1.0 8.8e-33 112.0 0.7 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) Cu_amine_oxidN2 PF02727.11 CCF38696.1 - 7.5e-06 25.9 0.0 2e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Peptidase_S8 PF00082.17 CCF38697.1 - 2.2e-49 168.1 0.2 3.6e-49 167.4 0.1 1.4 1 0 0 1 1 1 1 Subtilase family DUF1034 PF06280.7 CCF38697.1 - 2.5e-06 27.8 0.0 5.1e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Fn3-like domain (DUF1034) UQ_con PF00179.21 CCF38700.1 - 2.4e-36 124.2 0.0 6.5e-22 77.4 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CCF38700.1 - 0.01 15.6 0.0 1.6 8.4 0.0 2.4 2 0 0 2 2 2 2 Prokaryotic E2 family B Helicase_C PF00271.26 CCF38702.1 - 8.9e-18 63.9 0.0 1.4e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Homez PF11569.3 CCF38702.1 - 0.0064 15.5 0.1 0.018 14.1 0.1 1.7 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez HDA2-3 PF11496.3 CCF38702.1 - 0.018 13.8 0.0 0.023 13.4 0.0 1.1 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 MFS_1 PF07690.11 CCF38703.1 - 2e-26 92.5 45.1 4.2e-23 81.6 23.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF38703.1 - 0.011 15.5 2.0 0.027 14.2 0.3 2.5 3 0 0 3 3 3 0 MFS_1 like family UCH_1 PF13423.1 CCF38705.1 - 8e-55 186.3 0.0 1.1e-54 185.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.19 CCF38705.1 - 2.2e-27 96.3 0.0 3.8e-27 95.5 0.0 1.4 1 0 0 1 1 1 1 Exonuclease UCH PF00443.24 CCF38705.1 - 8e-06 25.1 0.0 2.9e-05 23.3 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ima1_N PF09779.4 CCF38705.1 - 0.2 12.1 0.5 0.46 10.9 0.3 1.6 1 0 0 1 1 1 0 Ima1 N-terminal domain adh_short PF00106.20 CCF38706.1 - 5e-23 81.8 3.5 4e-22 78.9 2.4 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF38706.1 - 2.3e-21 76.6 0.3 1.2e-20 74.2 0.2 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF38706.1 - 3.5e-11 43.1 1.5 1.1e-10 41.5 1.0 1.8 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF38706.1 - 0.00041 20.4 0.3 0.0013 18.8 0.1 1.9 1 1 1 2 2 2 1 NADH(P)-binding Shikimate_DH PF01488.15 CCF38706.1 - 0.006 16.6 0.1 0.012 15.7 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.22 CCF38706.1 - 0.017 15.4 0.7 0.044 14.1 0.3 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Polysacc_synt_2 PF02719.10 CCF38706.1 - 0.018 13.9 0.0 0.038 12.8 0.0 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.16 CCF38706.1 - 0.062 12.7 0.0 0.19 11.1 0.0 1.8 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family ETF PF01012.16 CCF38706.1 - 0.084 12.5 1.9 0.34 10.6 0.5 2.1 1 1 1 2 2 2 0 Electron transfer flavoprotein domain BUD22 PF09073.5 CCF38707.1 - 2.1e-70 237.9 42.6 7.2e-70 236.2 29.5 1.8 1 1 0 1 1 1 1 BUD22 SGT1 PF07093.6 CCF38707.1 - 0.08 11.3 21.3 0.13 10.5 14.8 1.3 1 0 0 1 1 1 0 SGT1 protein Antifungal_prot PF11402.3 CCF38708.1 - 0.19 11.9 3.6 0.39 10.9 2.5 1.6 1 1 0 1 1 1 0 Antifungal protein BBP1_C PF15272.1 CCF38709.1 - 0.0085 15.6 0.8 0.02 14.4 0.5 1.6 1 0 0 1 1 1 1 Spindle pole body component BBP1, C-terminal Lipocalin_5 PF13924.1 CCF38710.1 - 2.1e-26 92.2 0.1 2.4e-26 92.1 0.0 1.0 1 0 0 1 1 1 1 Lipocalin-like domain RNase_H PF00075.19 CCF38711.1 - 3.8e-14 53.1 0.0 9.7e-14 51.8 0.0 1.6 1 1 0 1 1 1 1 RNase H RVT_3 PF13456.1 CCF38711.1 - 0.00047 19.8 0.0 0.14 11.9 0.0 2.4 2 0 0 2 2 2 2 Reverse transcriptase-like DUF4139 PF13598.1 CCF38713.1 - 7.7e-59 199.5 20.5 6.8e-43 147.1 2.1 3.8 2 1 0 3 3 3 2 Domain of unknown function (DUF4139) DUF4140 PF13600.1 CCF38713.1 - 6.5e-11 42.6 2.9 6.5e-11 42.6 2.0 5.5 5 1 0 5 5 5 1 N-terminal domain of unknown function (DUF4140) RSN1_TM PF13967.1 CCF38714.1 - 3.3e-07 29.9 0.3 3.7e-07 29.8 0.2 1.1 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport Aldolase_II PF00596.16 CCF38715.1 - 8e-19 67.9 0.2 9.2e-19 67.7 0.1 1.0 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain CN_hydrolase PF00795.17 CCF38716.1 - 3.5e-25 88.4 0.0 5.9e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Fungal_trans_2 PF11951.3 CCF38717.1 - 1.6e-17 63.2 0.2 1.9e-17 62.9 0.1 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain HhH-GPD PF00730.20 CCF38718.1 - 1.8e-16 60.3 0.0 3.4e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein PALP PF00291.20 CCF38720.1 - 1.9e-38 132.4 0.1 2.5e-38 132.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PALP PF00291.20 CCF38721.1 - 2.7e-12 46.5 0.0 3.6e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Arginosuc_synth PF00764.14 CCF38722.1 - 9.2e-38 130.2 0.0 2.5e-24 86.0 0.0 2.1 1 1 1 2 2 2 2 Arginosuccinate synthase zf-Di19 PF05605.7 CCF38723.1 - 0.0099 15.9 0.1 0.023 14.7 0.0 1.6 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding Atg14 PF10186.4 CCF38723.1 - 0.012 14.5 0.9 0.012 14.5 0.6 2.3 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 zf-ribbon_3 PF13248.1 CCF38723.1 - 0.089 12.0 0.1 0.17 11.1 0.1 1.4 1 0 0 1 1 1 0 zinc-ribbon domain zf-C2HC_2 PF13913.1 CCF38723.1 - 0.12 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-C2H2 PF00096.21 CCF38723.1 - 0.13 12.6 0.1 0.29 11.5 0.1 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type AAT PF03417.11 CCF38723.1 - 2 7.8 13.2 4.1 6.7 9.1 1.5 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Hid1 PF12722.2 CCF38723.1 - 2.3 5.7 24.0 4.4 4.8 16.6 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Peptidase_U57 PF05582.7 CCF38723.1 - 2.9 6.7 11.5 6.2 5.6 7.9 1.6 1 0 0 1 1 1 0 YabG peptidase U57 Zip PF02535.17 CCF38723.1 - 4.4 6.2 7.1 9.2 5.1 4.9 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Cellulose_synt PF03552.9 CCF38723.1 - 4.6 5.4 9.5 7.2 4.7 6.6 1.2 1 0 0 1 1 1 0 Cellulose synthase Abhydrolase_3 PF07859.8 CCF38725.1 - 2.6e-32 112.1 0.0 3.3e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2424 PF10340.4 CCF38725.1 - 2.3e-13 49.5 0.0 3.4e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 CCF38725.1 - 0.0024 17.6 0.1 0.0037 17.0 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF38725.1 - 0.02 14.1 0.0 0.4 9.8 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family AraC_binding_2 PF14525.1 CCF38725.1 - 0.055 13.0 0.9 0.36 10.3 0.1 2.3 2 1 1 3 3 3 0 AraC-binding-like domain Peptidase_M14 PF00246.19 CCF38727.1 - 1e-21 77.8 0.0 1.5e-21 77.2 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase DUF2817 PF10994.3 CCF38727.1 - 0.049 12.7 0.0 0.067 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) AstE_AspA PF04952.9 CCF38727.1 - 0.077 11.8 0.1 0.13 11.1 0.1 1.4 1 1 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family MFS_1 PF07690.11 CCF38728.1 - 3.4e-18 65.5 41.5 1.3e-11 43.8 16.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily IU_nuc_hydro PF01156.14 CCF38729.1 - 4.4e-27 95.1 0.0 5.4e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase APH PF01636.18 CCF38730.1 - 2e-09 37.5 0.0 9.3e-09 35.3 0.0 2.1 2 1 0 2 2 2 1 Phosphotransferase enzyme family Prp18 PF02840.10 CCF38731.1 - 0.0021 17.9 3.7 0.27 11.0 0.0 2.3 1 1 1 2 2 2 2 Prp18 domain VCBS PF13517.1 CCF38732.1 - 4.8e-14 52.4 19.5 5e-09 36.3 6.0 3.2 2 1 1 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 CCF38732.1 - 3.2e-06 26.6 13.8 0.00021 20.8 0.3 3.4 3 1 0 3 3 3 2 FG-GAP repeat TcdB_toxin_midN PF12256.3 CCF38732.1 - 0.0004 19.8 1.8 0.13 11.7 0.0 2.4 1 1 1 2 2 2 2 Insecticide toxin TcdB middle/N-terminal region EF-hand_5 PF13202.1 CCF38732.1 - 0.89 9.0 3.5 13 5.2 0.1 3.0 3 0 0 3 3 3 0 EF hand MFS_1 PF07690.11 CCF38735.1 - 1.3e-32 112.8 44.7 7.5e-32 110.4 31.0 2.5 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2919 PF11143.3 CCF38735.1 - 0.00057 19.7 1.9 0.0097 15.7 0.1 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2919) Fijivirus_P9-2 PF06837.6 CCF38735.1 - 4.6 6.3 4.6 2.4 7.2 0.1 2.2 2 0 0 2 2 2 0 Fijivirus P9-2 protein DUF4407 PF14362.1 CCF38735.1 - 5.1 5.9 5.4 1.9 7.3 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) PHO4 PF01384.15 CCF38738.1 - 4.4e-100 334.5 16.0 5.1e-100 334.2 11.1 1.0 1 0 0 1 1 1 1 Phosphate transporter family SUR7 PF06687.7 CCF38739.1 - 3.5e-23 82.2 1.9 3.5e-23 82.2 1.3 1.3 1 1 0 1 1 1 1 SUR7/PalI family Claudin_2 PF13903.1 CCF38739.1 - 2.1e-05 24.2 3.9 2.1e-05 24.2 2.7 2.2 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction Trp_oprn_chp PF09534.5 CCF38739.1 - 0.017 14.7 2.0 0.049 13.2 0.0 2.3 2 1 1 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) EphA2_TM PF14575.1 CCF38739.1 - 0.055 13.8 3.8 0.47 10.8 0.0 2.9 2 1 1 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain zf-DHHC PF01529.15 CCF38739.1 - 0.11 11.9 0.1 2.1 7.7 0.2 2.1 1 1 1 2 2 2 0 DHHC palmitoyltransferase SIT PF15330.1 CCF38739.1 - 0.36 10.9 1.4 17 5.6 0.0 2.7 3 0 0 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT Herpes_gE PF02480.11 CCF38739.1 - 0.52 8.5 3.6 1 7.5 0.0 2.1 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E DUF3357 PF11837.3 CCF38739.1 - 0.66 9.8 2.0 5.9 6.7 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF3357) DUF2207 PF09972.4 CCF38739.1 - 1.7 7.1 4.8 13 4.2 3.2 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) SDF PF00375.13 CCF38739.1 - 2.3 6.8 10.9 0.15 10.7 2.1 2.4 3 0 0 3 3 3 0 Sodium:dicarboxylate symporter family DUF3487 PF11990.3 CCF38739.1 - 6.1 6.2 8.1 2.1 7.7 1.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3487) IncA PF04156.9 CCF38739.1 - 8.5 5.9 0.0 8.5 5.9 0.0 3.0 3 0 0 3 3 2 0 IncA protein APH PF01636.18 CCF38740.1 - 1.7e-10 41.0 7.9 4.1e-09 36.5 5.4 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CCF38740.1 - 0.072 12.6 0.1 1.2 8.6 0.0 2.2 2 0 0 2 2 2 0 Choline/ethanolamine kinase WD40 PF00400.27 CCF38741.1 - 6.5e-20 70.2 13.4 1.8e-05 24.4 0.3 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat MraZ PF02381.13 CCF38741.1 - 0.074 12.8 0.0 13 5.6 0.0 2.6 2 0 0 2 2 2 0 MraZ protein BBS2_N PF14781.1 CCF38741.1 - 0.13 11.8 0.0 0.39 10.3 0.0 1.8 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, N-terminal MR_MLE_C PF13378.1 CCF38742.1 - 0.0058 16.5 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 Enolase C-terminal domain-like Ribosomal_L11_N PF03946.9 CCF38743.1 - 9.6e-19 66.6 0.1 1.1e-18 66.4 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Sec23_trunk PF04811.10 CCF38744.1 - 3.5e-79 265.5 0.0 4.9e-79 265.1 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 CCF38744.1 - 1.3e-34 117.6 1.1 3.8e-34 116.2 0.1 2.2 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 CCF38744.1 - 5.1e-31 107.0 0.3 1.1e-30 106.0 0.2 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 CCF38744.1 - 1.4e-15 56.4 6.3 2.9e-15 55.5 4.4 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 CCF38744.1 - 2e-11 43.3 0.0 5.5e-11 41.9 0.0 1.8 2 0 0 2 2 2 1 Gelsolin repeat DUF2422 PF10337.4 CCF38745.1 - 3.6e-92 309.5 1.5 3.6e-92 309.5 1.1 2.9 2 1 0 2 2 2 1 Protein of unknown function (DUF2422) FUSC_2 PF13515.1 CCF38745.1 - 2.2e-09 37.3 14.7 2.2e-09 37.3 10.2 2.8 2 1 0 2 2 2 1 Fusaric acid resistance protein-like Serglycin PF04360.7 CCF38745.1 - 0.51 10.0 2.9 3.5 7.3 1.3 2.2 2 0 0 2 2 2 0 Serglycin Trypan_PARP PF05887.6 CCF38745.1 - 2.9 7.7 15.4 1.6 8.5 8.4 2.1 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) SHR3_chaperone PF08229.6 CCF38746.1 - 0.026 13.4 0.4 0.66 8.9 0.1 2.2 2 0 0 2 2 2 0 ER membrane protein SH3 DUF917 PF06032.7 CCF38747.1 - 2.8e-112 374.7 0.1 4.1e-112 374.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.13 CCF38747.1 - 1.4e-33 116.2 5.9 3.3e-33 115.0 4.1 1.7 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase p450 PF00067.17 CCF38748.1 - 3e-48 164.5 0.0 3.8e-48 164.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ILVD_EDD PF00920.16 CCF38750.1 - 2.9e-209 695.8 0.9 3.3e-209 695.6 0.7 1.0 1 0 0 1 1 1 1 Dehydratase family CLP_protease PF00574.18 CCF38751.1 - 9.2e-69 230.7 0.3 1.2e-68 230.3 0.2 1.1 1 0 0 1 1 1 1 Clp protease FMO-like PF00743.14 CCF38751.1 - 0.12 10.5 0.1 0.16 10.1 0.1 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like MFS_1 PF07690.11 CCF38752.1 - 7.3e-27 94.0 50.4 1.4e-15 56.8 23.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Actin PF00022.14 CCF38753.1 - 1e-71 241.4 0.0 1.4e-71 241.0 0.0 1.2 1 0 0 1 1 1 1 Actin LIP PF03583.9 CCF38753.1 - 0.099 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Secretory lipase F-box PF00646.28 CCF38754.1 - 2.6e-05 23.7 0.0 5.1e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 CCF38754.1 - 0.00024 20.7 0.0 0.0005 19.7 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box-like_2 PF13013.1 CCF38754.1 - 0.094 12.4 0.1 0.24 11.1 0.0 1.7 1 0 0 1 1 1 0 F-box-like domain PRANC PF09372.5 CCF38754.1 - 0.15 12.0 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 PRANC domain Histone PF00125.19 CCF38755.1 - 2.9e-21 75.3 0.1 3.8e-21 75.0 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 CCF38755.1 - 0.00017 21.5 0.0 0.00027 20.9 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Glyco_tranf_2_3 PF13641.1 CCF38756.1 - 2.9e-30 105.7 0.0 4.8e-30 105.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 CCF38756.1 - 5.7e-14 52.2 0.1 5.7e-14 52.2 0.1 2.6 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.21 CCF38756.1 - 8.1e-12 45.1 0.0 1.4e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 CCF38756.1 - 1.1e-10 41.0 0.0 1.9e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Cellulose_synt PF03552.9 CCF38756.1 - 2.8e-05 22.6 7.5 0.019 13.3 0.9 3.8 2 1 2 4 4 4 2 Cellulose synthase PEX11 PF05648.9 CCF38756.1 - 0.1 11.8 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) Dicty_CAR PF05462.6 CCF38756.1 - 0.74 8.6 9.4 0.12 11.2 0.4 2.6 3 0 0 3 3 3 0 Slime mold cyclic AMP receptor TPT PF03151.11 CCF38757.1 - 8.7e-22 77.4 9.4 8.7e-22 77.4 6.5 2.5 2 1 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 CCF38757.1 - 1.2e-05 24.4 18.7 5.2e-05 22.3 13.0 1.8 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 CCF38757.1 - 0.013 15.5 28.2 0.017 15.1 7.3 2.9 2 2 1 3 3 3 0 EamA-like transporter family APH PF01636.18 CCF38759.1 - 6.4e-07 29.3 0.9 6.4e-07 29.3 0.6 1.9 2 1 0 2 2 2 1 Phosphotransferase enzyme family SIR2 PF02146.12 CCF38761.1 - 1.3e-55 187.9 0.0 1.7e-55 187.5 0.0 1.2 1 0 0 1 1 1 1 Sir2 family BAH PF01426.13 CCF38762.1 - 1.7e-16 60.0 0.0 4.2e-16 58.7 0.0 1.7 1 0 0 1 1 1 1 BAH domain ELM2 PF01448.19 CCF38762.1 - 0.61 10.7 5.3 11 6.7 3.7 3.0 1 1 0 1 1 1 0 ELM2 domain FYVE_2 PF02318.11 CCF38762.1 - 4.5 7.1 10.3 11 5.9 1.2 3.0 3 0 0 3 3 3 0 FYVE-type zinc finger Trypsin_2 PF13365.1 CCF38763.1 - 1.8e-11 44.0 0.1 7.2e-11 42.1 0.0 2.1 2 0 0 2 2 2 1 Trypsin-like peptidase domain Trypsin PF00089.21 CCF38763.1 - 8.9e-08 31.9 0.1 2e-07 30.8 0.1 1.5 1 0 0 1 1 1 1 Trypsin Peptidase_C4 PF00863.14 CCF38763.1 - 0.0018 17.2 0.0 0.0033 16.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C4 Peptidase_C3 PF00548.15 CCF38763.1 - 0.0068 16.2 2.4 0.013 15.3 1.6 1.4 1 0 0 1 1 1 1 3C cysteine protease (picornain 3C) CorA PF01544.13 CCF38764.1 - 0.00083 18.4 5.1 0.0014 17.7 3.5 1.4 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein RNA_pol_L_2 PF13656.1 CCF38765.1 - 2.4e-28 97.3 0.0 3e-28 97.0 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 CCF38765.1 - 5.6e-09 34.9 0.0 7.1e-09 34.6 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Glyco_hydro_47 PF01532.15 CCF38767.1 - 1.6e-162 541.3 0.0 1.8e-162 541.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Sugar_tr PF00083.19 CCF38768.1 - 0.0065 15.0 0.2 0.0075 14.8 0.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Shikimate_dh_N PF08501.6 CCF38769.1 - 2.9e-21 75.3 0.0 5.9e-21 74.3 0.0 1.5 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.15 CCF38769.1 - 1.5e-16 60.6 0.0 2.6e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase COX16 PF14138.1 CCF38771.1 - 4.1e-33 113.3 0.3 5.4e-33 113.0 0.2 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 zf-P11 PF03854.9 CCF38772.1 - 0.004 16.6 2.9 0.0061 16.0 2.0 1.2 1 0 0 1 1 1 1 P-11 zinc finger DUF605 PF04652.11 CCF38777.1 - 3.7 6.8 10.5 3.5 6.9 7.3 1.0 1 0 0 1 1 1 0 Vta1 like Tho2 PF11262.3 CCF38778.1 - 4.8e-67 226.1 0.0 6.4e-67 225.6 0.0 1.1 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 SAM_2 PF07647.12 CCF38779.1 - 8.8e-11 41.5 0.1 1.5e-10 40.7 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 CCF38779.1 - 3.2e-06 27.2 0.3 5.7e-06 26.4 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) IGR PF09597.5 CCF38779.1 - 0.036 13.9 0.2 0.093 12.6 0.1 1.6 1 0 0 1 1 1 0 IGR protein motif TPR_MLP1_2 PF07926.7 CCF38780.1 - 4.9e-31 107.2 28.7 4.9e-31 107.2 19.9 11.1 6 4 2 9 9 9 4 TPR/MLP1/MLP2-like protein DUF904 PF06005.7 CCF38780.1 - 0.00023 21.3 5.1 0.00023 21.3 3.5 16.3 9 6 4 13 13 13 1 Protein of unknown function (DUF904) CENP-Q PF13094.1 CCF38780.1 - 0.0023 17.9 12.4 0.0023 17.9 8.6 10.5 2 2 9 11 11 11 4 CENP-Q, a CENPA-CAD centromere complex subunit FlaC_arch PF05377.6 CCF38780.1 - 0.014 15.2 0.7 0.014 15.2 0.5 12.7 12 3 2 14 14 14 0 Flagella accessory protein C (FlaC) Glyco_hydro_47 PF01532.15 CCF38781.1 - 3.2e-136 454.6 0.0 3.9e-136 454.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 FAA_hydrolase PF01557.13 CCF38782.1 - 7.7e-60 202.0 0.0 1.4e-59 201.2 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Abhydrolase_6 PF12697.2 CCF38782.1 - 3.7e-37 128.3 0.7 6e-37 127.7 0.5 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF38782.1 - 3.9e-19 68.8 0.0 1.3e-17 63.8 0.0 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF38782.1 - 4.7e-18 65.5 0.0 3.4e-16 59.5 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.8 CCF38782.1 - 1.7e-08 34.2 0.0 1.8e-05 24.4 0.0 2.5 1 1 0 1 1 1 1 Serine hydrolase Abhydrolase_4 PF08386.5 CCF38782.1 - 0.0019 18.0 0.0 0.0044 16.8 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Esterase PF00756.15 CCF38782.1 - 0.0083 15.5 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Putative esterase LCAT PF02450.10 CCF38782.1 - 0.013 14.4 0.0 0.034 13.1 0.0 1.6 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.3 CCF38782.1 - 0.094 12.5 0.0 0.44 10.4 0.0 2.1 2 0 0 2 2 2 0 Putative lysophospholipase Aminotran_4 PF01063.14 CCF38783.1 - 0.016 14.6 0.1 0.02 14.3 0.0 1.1 1 0 0 1 1 1 0 Aminotransferase class IV AA_permease PF00324.16 CCF38784.1 - 2e-121 405.6 41.2 2.5e-121 405.3 28.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF38784.1 - 4.4e-29 101.2 47.4 6e-29 100.8 32.9 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3580 PF12117.3 CCF38785.1 - 0.0053 16.6 0.1 0.0062 16.4 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3580) AMP-binding PF00501.23 CCF38786.1 - 1.3e-72 244.5 0.0 1.6e-72 244.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF38786.1 - 1.4e-05 25.9 0.1 3.1e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Fungal_trans_2 PF11951.3 CCF38788.1 - 4.4e-07 28.8 0.1 6.4e-07 28.2 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain FMO-like PF00743.14 CCF38789.1 - 4e-25 88.0 0.0 2.3e-21 75.6 0.0 2.5 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 CCF38789.1 - 1e-14 55.1 0.0 1.7e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF38789.1 - 3.7e-08 33.2 0.0 1.2e-07 31.6 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 CCF38789.1 - 3.8e-08 32.6 0.1 6.3e-06 25.3 0.0 3.2 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 CCF38789.1 - 9.7e-07 28.8 0.0 3.3e-06 27.1 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF38789.1 - 2.5e-06 27.3 0.1 3.2e-05 23.7 0.0 2.8 2 1 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.22 CCF38789.1 - 0.00013 22.2 0.3 0.19 12.1 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF38789.1 - 0.00039 19.4 0.0 0.0062 15.4 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.12 CCF38789.1 - 0.002 17.2 0.1 0.0044 16.1 0.0 1.5 2 0 0 2 2 2 1 Thi4 family Shikimate_DH PF01488.15 CCF38789.1 - 0.069 13.2 0.1 2.2 8.3 0.0 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_Gly3P_dh_N PF01210.18 CCF38789.1 - 0.082 12.6 0.0 0.43 10.2 0.0 2.1 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus HI0933_like PF03486.9 CCF38789.1 - 0.11 10.9 0.1 0.25 9.7 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein ThiF PF00899.16 CCF38789.1 - 0.14 11.9 0.1 2.7 7.7 0.0 2.3 2 0 0 2 2 2 0 ThiF family NmrA PF05368.8 CCF38790.1 - 1.5e-12 47.2 0.0 1.8e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF38790.1 - 1.1e-08 35.3 0.0 2.5e-08 34.1 0.0 1.6 2 0 0 2 2 2 1 NADH(P)-binding Gcd10p PF04189.8 CCF38791.1 - 1.1e-72 244.7 0.0 2.9e-72 243.3 0.0 1.7 1 1 0 1 1 1 1 Gcd10p family P21-Arc PF04062.9 CCF38792.1 - 2.9e-78 261.6 0.0 3.3e-78 261.4 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit Hormone_3 PF00159.13 CCF38792.1 - 0.008 16.1 0.8 0.018 15.0 0.6 1.5 1 0 0 1 1 1 1 Pancreatic hormone peptide zf-C2H2_4 PF13894.1 CCF38794.1 - 0.0022 18.1 6.7 0.45 10.9 0.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF38794.1 - 6.5 7.3 12.3 2.5 8.5 0.2 3.0 2 1 0 2 2 2 0 Zinc finger, C2H2 type Kinesin PF00225.18 CCF38795.1 - 1.1e-93 313.6 0.0 5.8e-93 311.2 0.0 2.3 1 0 0 1 1 1 1 Kinesin motor domain Reo_sigmaC PF04582.7 CCF38795.1 - 1 8.4 36.7 0.75 8.9 2.9 5.1 4 1 1 5 5 5 0 Reovirus sigma C capsid protein E1-E2_ATPase PF00122.15 CCF38796.1 - 9.2e-19 67.3 0.0 1.6e-18 66.6 0.0 1.3 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_like2 PF13246.1 CCF38796.1 - 1e-10 41.3 0.0 2.2e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 CCF38796.1 - 0.1 12.7 0.0 0.19 11.8 0.0 1.6 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase CDC50 PF03381.10 CCF38797.1 - 6.8e-52 176.3 0.0 8e-52 176.1 0.0 1.0 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF3285 PF11688.3 CCF38797.1 - 0.011 15.3 0.2 0.02 14.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3285) Lipase_GDSL_2 PF13472.1 CCF38798.1 - 1.2e-12 48.3 0.3 1.7e-12 47.8 0.2 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 CCF38798.1 - 1.2e-12 48.1 0.1 1.5e-12 47.8 0.1 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF716 PF04819.7 CCF38799.1 - 0.13 11.6 2.2 0.19 11.1 1.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF716) ABC_tran PF00005.22 CCF38800.1 - 3.4e-33 114.8 0.0 2.4e-15 57.0 0.0 2.5 2 0 0 2 2 2 2 ABC transporter RLI PF04068.10 CCF38800.1 - 4.7e-14 51.6 5.5 4.7e-14 51.6 3.8 2.0 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.14 CCF38800.1 - 2.5e-12 46.4 0.2 0.00012 21.4 0.0 3.3 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF38800.1 - 2.4e-11 44.1 10.3 0.082 12.8 0.0 5.2 4 2 1 6 6 5 4 AAA domain AAA_15 PF13175.1 CCF38800.1 - 4.5e-08 32.5 0.2 0.49 9.3 0.0 4.3 3 1 0 4 4 4 2 AAA ATPase domain AAA_17 PF13207.1 CCF38800.1 - 8.2e-07 29.8 0.1 0.039 14.7 0.0 3.0 2 2 0 2 2 2 2 AAA domain AAA_18 PF13238.1 CCF38800.1 - 7.6e-06 26.2 0.2 0.38 11.0 0.0 3.5 2 1 1 3 3 3 2 AAA domain AAA PF00004.24 CCF38800.1 - 1.2e-05 25.5 0.1 0.012 15.8 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CCF38800.1 - 2.2e-05 24.5 0.0 0.011 15.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 CCF38800.1 - 2.7e-05 23.6 0.3 0.042 13.3 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain Fer4 PF00037.22 CCF38800.1 - 0.0001 21.7 1.3 0.0001 21.7 0.9 2.7 3 0 0 3 3 3 1 4Fe-4S binding domain AAA_23 PF13476.1 CCF38800.1 - 0.0003 21.1 0.0 0.034 14.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 CCF38800.1 - 0.00034 19.8 3.2 0.45 9.7 0.0 3.2 3 0 0 3 3 3 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 CCF38800.1 - 0.00051 20.0 0.0 0.29 11.0 0.0 2.6 3 0 0 3 3 2 1 AAA ATPase domain RNA_helicase PF00910.17 CCF38800.1 - 0.00054 20.1 0.1 0.3 11.2 0.0 2.8 2 0 0 2 2 2 1 RNA helicase UPF0079 PF02367.12 CCF38800.1 - 0.00074 19.1 0.3 0.0076 15.8 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 MobB PF03205.9 CCF38800.1 - 0.00096 18.8 1.1 0.14 11.8 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Fer4_21 PF14697.1 CCF38800.1 - 0.0015 18.3 10.7 0.003 17.3 7.4 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain VirE PF05272.6 CCF38800.1 - 0.0015 18.0 0.0 1.5 8.2 0.0 2.6 2 0 0 2 2 2 1 Virulence-associated protein E SRP54 PF00448.17 CCF38800.1 - 0.0018 17.7 2.2 0.078 12.4 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_33 PF13671.1 CCF38800.1 - 0.0018 18.1 0.0 0.13 12.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 CCF38800.1 - 0.0019 17.8 1.4 0.23 11.0 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.1 CCF38800.1 - 0.0043 16.4 0.1 2.2 7.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 CCF38800.1 - 0.0045 16.7 0.2 0.22 11.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Fer4_7 PF12838.2 CCF38800.1 - 0.0087 16.4 8.0 0.0092 16.3 0.3 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain AAA_13 PF13166.1 CCF38800.1 - 0.011 14.2 0.0 0.011 14.2 0.0 2.2 4 0 0 4 4 2 0 AAA domain Rad17 PF03215.10 CCF38800.1 - 0.011 14.4 0.0 0.13 10.9 0.0 2.1 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein Thymidylate_kin PF02223.12 CCF38800.1 - 0.013 14.8 0.5 2.8 7.2 0.0 2.8 3 0 0 3 3 3 0 Thymidylate kinase Miro PF08477.8 CCF38800.1 - 0.022 15.2 0.0 1.6 9.2 0.0 2.8 2 0 0 2 2 2 0 Miro-like protein AAA_28 PF13521.1 CCF38800.1 - 0.025 14.5 0.5 1.5 8.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain Fer4_6 PF12837.2 CCF38800.1 - 0.032 14.0 10.7 0.048 13.5 0.8 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain NB-ARC PF00931.17 CCF38800.1 - 0.053 12.3 0.0 2.6 6.8 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain Fer4_16 PF13484.1 CCF38800.1 - 0.065 13.9 0.1 0.065 13.9 0.1 2.6 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain KaiC PF06745.8 CCF38800.1 - 0.12 11.4 0.1 0.34 9.9 0.0 1.8 2 0 0 2 2 1 0 KaiC PduV-EutP PF10662.4 CCF38800.1 - 0.18 11.2 4.0 0.32 10.4 0.0 2.8 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Fer4_8 PF13183.1 CCF38800.1 - 0.19 11.7 9.1 0.26 11.3 1.2 1.8 1 1 1 2 2 2 0 4Fe-4S dicluster domain AAA_14 PF13173.1 CCF38800.1 - 0.2 11.5 1.2 18 5.2 0.0 3.3 2 2 0 2 2 2 0 AAA domain T2SE PF00437.15 CCF38800.1 - 0.22 10.3 0.7 3.7 6.3 0.0 2.8 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_30 PF13604.1 CCF38800.1 - 0.22 11.0 0.1 3.6 7.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 CCF38800.1 - 0.24 11.0 1.5 12 5.5 0.0 2.5 2 0 0 2 2 2 0 NTPase AAA_24 PF13479.1 CCF38800.1 - 0.51 9.8 2.1 2.7 7.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Fer4_2 PF12797.2 CCF38800.1 - 1.2 9.1 12.0 0.65 10.0 1.4 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_10 PF13237.1 CCF38800.1 - 1.4 8.7 15.9 0.067 13.0 1.2 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_9 PF13187.1 CCF38800.1 - 1.4 9.2 13.3 0.094 12.9 1.5 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain LST1 PF05083.8 CCF38803.1 - 1.6 8.7 5.9 3.2 7.8 0.0 2.4 2 0 0 2 2 2 0 LST-1 protein p450 PF00067.17 CCF38804.1 - 1.9e-70 237.6 0.0 2.9e-70 237.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.15 CCF38804.1 - 1.5e-18 67.0 0.0 2.9e-18 66.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 CCF38804.1 - 1.4e-17 64.0 0.0 2.5e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 CCF38804.1 - 7.9e-07 29.6 0.0 2.6e-06 27.9 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 CCF38804.1 - 0.0017 18.2 0.0 0.004 17.0 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_6 PF00970.19 CCF38804.1 - 0.0032 17.5 0.0 0.0096 16.0 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain PrmA PF06325.8 CCF38804.1 - 0.12 11.4 0.0 0.23 10.5 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) RasGAP PF00616.14 CCF38806.1 - 3e-44 151.0 0.0 6.1e-44 150.0 0.0 1.6 1 1 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.25 CCF38806.1 - 0.01 15.6 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 C2 domain HET PF06985.6 CCF38807.1 - 2.6e-22 79.4 3.2 1.3e-18 67.4 0.1 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) MFS_1 PF07690.11 CCF38808.1 - 1.6e-08 33.6 8.4 7.3e-08 31.4 5.7 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF38808.1 - 0.065 11.8 4.6 0.083 11.4 3.0 1.3 1 1 0 1 1 1 0 Sugar (and other) transporter Lectin_N PF03954.9 CCF38808.1 - 0.087 12.2 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain ketoacyl-synt PF00109.21 CCF38809.1 - 4.6e-75 252.3 0.1 8.4e-75 251.5 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.1 CCF38809.1 - 1.2e-53 182.2 0.0 2.4e-53 181.2 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.16 CCF38809.1 - 8.4e-46 156.7 0.1 1.6e-45 155.8 0.1 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.17 CCF38809.1 - 1.3e-35 121.8 0.1 3.3e-35 120.5 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.7 CCF38809.1 - 8.4e-19 67.8 0.0 1.9e-18 66.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF38809.1 - 7.1e-13 48.5 0.0 1.5e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF38809.1 - 6.9e-09 36.2 0.0 2.3e-08 34.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF38809.1 - 2.9e-08 34.0 0.0 7.3e-08 32.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF38809.1 - 7.5e-07 28.8 0.0 1.7e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF38809.1 - 7.8e-06 25.1 0.0 1.5e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Thiolase_N PF00108.18 CCF38809.1 - 3.7e-05 22.8 0.1 9.1e-05 21.5 0.1 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain NodS PF05401.6 CCF38809.1 - 0.00092 18.6 0.0 0.0017 17.8 0.0 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) ACP_syn_III PF08545.5 CCF38809.1 - 0.0019 17.7 0.2 0.0068 16.0 0.1 2.0 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Methyltransf_8 PF05148.10 CCF38809.1 - 0.069 12.7 0.0 0.18 11.3 0.0 1.6 1 0 0 1 1 1 0 Hypothetical methyltransferase Beta-lactamase PF00144.19 CCF38810.1 - 1.3e-49 169.0 0.0 1.5e-49 168.8 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S13 PF02113.10 CCF38810.1 - 0.14 10.5 0.0 0.24 9.8 0.0 1.3 1 0 0 1 1 1 0 D-Ala-D-Ala carboxypeptidase 3 (S13) family p450 PF00067.17 CCF38811.1 - 9.5e-36 123.2 0.0 1.5e-35 122.6 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 ketoacyl-synt PF00109.21 CCF38812.1 - 1.5e-77 260.4 0.2 2.3e-77 259.8 0.1 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 CCF38812.1 - 7.9e-34 116.0 0.0 1.6e-33 115.0 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 CCF38812.1 - 3e-06 26.4 0.0 4.9e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 CCF38812.1 - 0.033 13.8 1.0 0.31 10.7 0.6 2.3 1 1 1 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Glutaredoxin PF00462.19 CCF38813.1 - 1.1e-15 57.2 0.0 2.6e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin G_glu_transpept PF01019.16 CCF38814.1 - 5.8e-128 427.5 0.0 1.6e-127 426.0 0.0 1.6 1 1 0 1 1 1 1 Gamma-glutamyltranspeptidase bZIP_1 PF00170.16 CCF38816.1 - 3.6e-11 42.8 2.3 5.4e-11 42.2 1.6 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 CCF38816.1 - 2.2e-05 24.1 7.2 4e-05 23.3 5.0 1.3 1 0 0 1 1 1 1 Basic region leucine zipper TTKRSYEDQ PF10212.4 CCF38816.1 - 0.063 12.1 0.0 0.084 11.7 0.0 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein BolA PF01722.13 CCF38820.1 - 2.9e-28 97.6 1.6 3.8e-28 97.2 1.1 1.1 1 0 0 1 1 1 1 BolA-like protein DUF830 PF05708.7 CCF38820.1 - 0.053 13.5 0.7 0.07 13.1 0.5 1.2 1 0 0 1 1 1 0 Orthopoxvirus protein of unknown function (DUF830) RPA_C PF08784.6 CCF38820.1 - 0.089 13.2 0.1 0.13 12.7 0.1 1.3 1 1 0 1 1 1 0 Replication protein A C terminal DNA_gyraseB PF00204.20 CCF38823.1 - 0.019 14.1 0.4 0.02 14.1 0.3 1.0 1 0 0 1 1 1 0 DNA gyrase B Imm29 PF15575.1 CCF38823.1 - 0.067 12.7 0.0 0.069 12.7 0.0 1.0 1 0 0 1 1 1 0 Immunity protein 29 ABC_tran_2 PF12848.2 CCF38823.1 - 0.72 9.7 5.1 1.1 9.1 3.5 1.3 1 0 0 1 1 1 0 ABC transporter ADH_zinc_N PF00107.21 CCF38825.1 - 6.2e-30 103.4 0.8 6.2e-30 103.4 0.5 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF38825.1 - 4.5e-18 66.3 1.1 1.1e-17 65.1 0.0 2.0 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF38825.1 - 7.6e-10 38.5 0.0 1.8e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.13 CCF38825.1 - 0.00035 20.5 0.0 0.00061 19.7 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain AlaDh_PNT_C PF01262.16 CCF38825.1 - 0.087 12.3 0.2 0.15 11.5 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Collagen PF01391.13 CCF38827.1 - 0.025 14.1 4.9 0.037 13.5 3.4 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Clr5 PF14420.1 CCF38828.1 - 6.7e-14 51.5 3.5 8.1e-14 51.2 2.0 1.4 1 1 0 1 1 1 1 Clr5 domain zf-Nse PF11789.3 CCF38831.1 - 0.0001 21.7 0.0 0.00018 20.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit PBP1_TM PF14812.1 CCF38831.1 - 5.6 7.3 10.3 1 9.7 3.9 2.1 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Hexokinase_2 PF03727.11 CCF38832.1 - 8.1e-36 123.4 0.0 6e-35 120.6 0.0 2.0 1 1 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 CCF38832.1 - 6.7e-28 97.4 0.0 9.7e-28 96.9 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Glucosamine_iso PF01182.15 CCF38833.1 - 3.6e-24 85.6 0.0 5.9e-24 84.8 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase DUF3464 PF11947.3 CCF38833.1 - 0.08 12.3 1.8 5.3 6.4 1.2 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3464) NDT80_PhoG PF05224.7 CCF38834.1 - 2.3e-33 115.7 0.0 4.9e-33 114.6 0.0 1.5 2 0 0 2 2 2 1 NDT80 / PhoG like DNA-binding family Amidohydro_4 PF13147.1 CCF38835.1 - 8.6e-15 55.5 0.5 1.2e-13 51.7 0.4 2.4 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 CCF38835.1 - 8e-09 35.5 0.3 4.9e-07 29.7 0.2 2.4 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 CCF38835.1 - 1.5e-06 27.7 0.1 4.2e-06 26.2 0.0 1.7 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_5 PF13594.1 CCF38835.1 - 8.7e-06 25.4 0.0 3e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 Amidohydrolase DSHCT PF08148.7 CCF38835.1 - 0.16 11.2 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 DSHCT (NUC185) domain Glyco_hydro_3 PF00933.16 CCF38836.1 - 0.011 14.7 0.0 0.011 14.7 0.0 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 N terminal domain Sof1 PF04158.9 CCF38836.1 - 0.11 12.4 0.0 0.14 12.2 0.0 1.1 1 0 0 1 1 1 0 Sof1-like domain zf-B_box PF00643.19 CCF38837.1 - 0.0056 16.5 3.5 0.0097 15.7 2.4 1.4 1 0 0 1 1 1 1 B-box zinc finger zf-C3HC4_2 PF13923.1 CCF38837.1 - 0.82 9.7 6.4 1.4 9.0 4.4 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.20 CCF38839.1 - 1.8e-38 132.2 0.0 2.3e-38 131.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF38839.1 - 1.1e-13 50.9 0.0 1.5e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CCF38839.1 - 1.9e-05 24.4 0.0 0.002 17.8 0.0 2.5 2 1 0 3 3 3 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 CCF38839.1 - 0.062 12.0 0.1 0.095 11.4 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase p450 PF00067.17 CCF38840.1 - 4.6e-12 45.2 0.0 5.2e-12 45.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.20 CCF38842.1 - 2.3e-47 161.3 0.0 3.2e-47 160.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF38842.1 - 2.6e-16 59.4 0.0 3.4e-16 59.0 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CCF38842.1 - 0.00078 19.2 0.0 0.0013 18.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 CCF38842.1 - 0.029 13.4 0.0 0.045 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 CCF38842.1 - 0.15 11.0 0.0 0.21 10.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Sugar_tr PF00083.19 CCF38843.1 - 4.8e-30 104.5 12.8 5.6e-30 104.3 8.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF38843.1 - 1.8e-09 36.7 13.8 2.4e-09 36.4 9.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 CCF38843.1 - 0.014 14.9 3.3 0.014 14.9 2.3 1.5 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 SelP_N PF04592.9 CCF38844.1 - 0.31 10.3 5.8 0.5 9.7 4.0 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zip PF02535.17 CCF38844.1 - 4.8 6.0 7.0 6.2 5.7 4.8 1.3 1 1 0 1 1 1 0 ZIP Zinc transporter BAF1_ABF1 PF04684.8 CCF38844.1 - 9.7 4.9 11.5 14 4.3 8.0 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor YCII PF03795.9 CCF38845.1 - 7.9e-10 38.8 0.0 1.1e-09 38.3 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain Pkinase PF00069.20 CCF38846.1 - 1.3e-20 73.6 0.0 5.9e-20 71.5 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF38846.1 - 1.5e-10 40.5 0.0 5.2e-10 38.8 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF38846.1 - 0.0041 16.1 0.0 0.015 14.2 0.0 1.8 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 CCF38846.1 - 0.012 14.6 0.0 0.018 14.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 CCF38846.1 - 0.03 13.6 0.0 0.045 13.0 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL SOBP PF15279.1 CCF38848.1 - 0.019 15.3 4.3 0.014 15.7 1.3 1.9 2 0 0 2 2 2 0 Sine oculis-binding protein Macoilin PF09726.4 CCF38848.1 - 0.22 9.7 7.5 0.31 9.2 5.2 1.2 1 0 0 1 1 1 0 Transmembrane protein Pex14_N PF04695.8 CCF38848.1 - 1.3 9.0 14.2 0.041 13.9 4.9 2.0 2 1 1 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Pol_alpha_B_N PF08418.5 CCF38848.1 - 5.6 6.4 14.0 12 5.3 9.7 1.5 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Sec3_C PF09763.4 CCF38848.1 - 6.2 4.8 8.0 8.2 4.4 5.5 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 SSP160 PF06933.6 CCF38848.1 - 9.1 4.1 45.1 1 7.2 1.5 2.5 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 CENP-I PF07778.6 CCF38849.1 - 1.2e-39 135.9 0.0 1.6e-39 135.5 0.0 1.1 1 0 0 1 1 1 1 Mis6 ABC_tran PF00005.22 CCF38850.1 - 5.4e-16 59.1 0.6 5.3e-15 55.9 0.1 2.4 2 1 0 2 2 1 1 ABC transporter AAA_21 PF13304.1 CCF38850.1 - 1.3e-10 41.7 0.2 0.00032 20.7 0.2 2.1 2 0 0 2 2 2 2 AAA domain DUF3584 PF12128.3 CCF38850.1 - 0.0013 16.1 0.2 0.0017 15.8 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) AAA_29 PF13555.1 CCF38850.1 - 0.0015 18.0 0.4 0.0015 18.0 0.3 1.6 2 0 0 2 2 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 CCF38850.1 - 0.0015 17.6 0.0 0.21 10.5 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.14 CCF38850.1 - 0.0027 16.9 0.0 1.9 7.6 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 CCF38850.1 - 0.0062 17.3 0.9 0.021 15.6 0.6 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF38850.1 - 0.0074 16.2 0.2 0.013 15.5 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.1 CCF38850.1 - 0.0081 16.5 0.1 0.012 15.9 0.1 1.2 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.4 CCF38850.1 - 0.0083 15.6 0.1 0.013 14.9 0.1 1.2 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.1 CCF38850.1 - 0.018 15.0 0.5 0.033 14.1 0.3 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 CCF38850.1 - 0.02 14.2 0.6 0.062 12.6 0.4 1.8 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.17 CCF38850.1 - 0.032 13.6 0.1 0.043 13.2 0.1 1.4 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain DUF258 PF03193.11 CCF38850.1 - 0.039 13.1 0.0 0.066 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Arf PF00025.16 CCF38850.1 - 0.054 12.7 0.3 0.12 11.5 0.2 1.7 1 1 0 1 1 1 0 ADP-ribosylation factor family AAA_22 PF13401.1 CCF38850.1 - 0.065 13.3 1.2 0.2 11.7 0.0 2.2 3 0 0 3 3 3 0 AAA domain AAA_10 PF12846.2 CCF38850.1 - 0.075 12.4 0.0 0.096 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_14 PF13173.1 CCF38850.1 - 0.088 12.7 0.1 0.28 11.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 CCF38850.1 - 0.1 12.8 0.4 0.29 11.3 0.3 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.13 CCF38850.1 - 0.11 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family NACHT PF05729.7 CCF38850.1 - 0.13 11.9 0.1 0.21 11.2 0.1 1.3 1 0 0 1 1 1 0 NACHT domain AAA_13 PF13166.1 CCF38850.1 - 0.14 10.5 0.1 0.2 10.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 CCF38850.1 - 0.2 11.0 0.3 0.3 10.5 0.2 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Glyco_transf_15 PF01793.11 CCF38851.1 - 1.3e-59 201.8 0.0 5.2e-58 196.5 0.0 2.1 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase BTB PF00651.26 CCF38852.1 - 0.00012 22.0 0.0 0.00033 20.5 0.0 1.7 1 1 0 1 1 1 1 BTB/POZ domain Cyclin PF08613.6 CCF38853.1 - 1.9e-36 125.7 0.0 2.5e-36 125.3 0.0 1.2 1 0 0 1 1 1 1 Cyclin COesterase PF00135.23 CCF38854.1 - 1.7e-105 353.7 0.0 2.2e-105 353.4 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF38854.1 - 0.0014 18.2 0.3 0.014 14.9 0.2 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold ECH_C PF13766.1 CCF38854.1 - 0.11 12.6 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 2-enoyl-CoA Hydratase C-terminal region Methyltransf_23 PF13489.1 CCF38855.1 - 0.0063 16.2 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Jacalin PF01419.12 CCF38857.1 - 0.21 11.4 0.2 0.46 10.3 0.0 1.6 2 0 0 2 2 2 0 Jacalin-like lectin domain DUF2331 PF10093.4 CCF38857.1 - 5.9 5.5 10.5 10 4.7 7.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2331) La PF05383.12 CCF38858.1 - 0.0064 16.2 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 La domain Got1 PF04178.7 CCF38860.1 - 4.3e-31 107.4 16.4 5.5e-31 107.1 11.4 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family Peptidase_M50 PF02163.17 CCF38860.1 - 0.024 13.5 0.0 0.03 13.2 0.0 1.4 1 1 0 1 1 1 0 Peptidase family M50 NfeD PF01957.13 CCF38860.1 - 1.2 9.2 5.8 0.42 10.7 2.0 1.6 1 1 1 2 2 2 0 NfeD-like C-terminal, partner-binding ATP12 PF07542.6 CCF38862.1 - 0.00022 21.1 0.1 0.00053 19.9 0.0 1.7 2 0 0 2 2 2 1 ATP12 chaperone protein Mito_fiss_reg PF05308.6 CCF38862.1 - 0.057 12.7 1.2 0.078 12.3 0.8 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator Fungal_trans PF04082.13 CCF38865.1 - 2.2e-10 39.8 0.0 5.1e-10 38.6 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF38865.1 - 2.1e-08 33.9 9.1 3.6e-08 33.1 6.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CwfJ_C_1 PF04677.10 CCF38866.1 - 5.2e-24 84.2 0.0 9.5e-24 83.3 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.9 CCF38866.1 - 1.5e-19 70.2 0.5 3.5e-19 69.0 0.3 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 B12-binding_2 PF02607.12 CCF38867.1 - 0.048 13.6 0.1 0.21 11.6 0.0 2.1 1 0 0 1 1 1 0 B12 binding domain DUF3818 PF12825.2 CCF38868.1 - 2.8e-39 134.7 0.1 5.2e-24 84.5 0.0 2.2 1 1 1 2 2 2 2 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.2 CCF38868.1 - 9.9e-31 106.1 0.0 1.7e-30 105.4 0.0 1.4 1 0 0 1 1 1 1 PX-associated PAD_porph PF04371.10 CCF38868.1 - 0.12 11.4 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Porphyromonas-type peptidyl-arginine deiminase Peptidase_C48 PF02902.14 CCF38869.1 - 1.1e-14 54.6 0.0 3.4e-14 52.9 0.0 1.8 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain AIG2_2 PF13772.1 CCF38870.1 - 1.3e-06 28.4 0.0 1.1e-05 25.3 0.0 2.1 2 0 0 2 2 2 1 AIG2-like family Zn_clus PF00172.13 CCF38871.1 - 2.2e-09 37.0 7.9 2.2e-09 37.0 5.5 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF38871.1 - 4.5e-08 32.2 0.1 8e-08 31.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-CCCH PF00642.19 CCF38872.1 - 1.6e-10 40.4 8.3 3.1e-05 23.5 1.5 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 CCF38872.1 - 0.012 15.5 16.4 0.027 14.4 2.7 2.8 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type PP-binding PF00550.20 CCF38873.1 - 1.4e-11 44.4 0.1 2.1e-11 43.9 0.1 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.1 CCF38873.1 - 7e-06 25.9 0.1 8.7e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 Acyl-carrier S-AdoMet_synt_C PF02773.11 CCF38873.1 - 0.036 13.7 0.3 0.065 12.9 0.2 1.4 1 1 0 1 1 1 0 S-adenosylmethionine synthetase, C-terminal domain DEAD PF00270.24 CCF38874.1 - 3e-44 150.4 2.5 3.8e-44 150.1 1.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF38874.1 - 1.2e-27 95.5 0.3 6.2e-27 93.2 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF38874.1 - 0.00073 19.4 0.1 0.0015 18.3 0.1 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 CCF38874.1 - 0.0022 17.5 0.3 0.0062 16.1 0.1 1.8 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CCF38874.1 - 0.016 14.9 0.1 0.046 13.4 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain AAA_22 PF13401.1 CCF38874.1 - 0.022 14.8 0.2 0.085 12.9 0.1 2.0 1 1 0 1 1 1 0 AAA domain CMS1 PF14617.1 CCF38874.1 - 0.023 13.7 0.0 0.05 12.6 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit UvrD-helicase PF00580.16 CCF38874.1 - 0.058 12.6 0.4 0.083 12.1 0.2 1.4 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain Flavi_DEAD PF07652.9 CCF38874.1 - 0.066 12.9 0.2 0.32 10.7 0.1 2.2 1 1 0 1 1 1 0 Flavivirus DEAD domain tRNA-synt_1b PF00579.20 CCF38874.1 - 0.067 12.3 0.2 0.29 10.2 0.0 2.0 3 0 0 3 3 3 0 tRNA synthetases class I (W and Y) CobA_CobO_BtuR PF02572.10 CCF38874.1 - 0.081 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Helicase_RecD PF05127.9 CCF38874.1 - 0.083 12.5 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 Helicase Fanconi_A PF03511.9 CCF38874.1 - 0.1 12.4 0.1 0.21 11.3 0.1 1.5 1 0 0 1 1 1 0 Fanconi anaemia group A protein dCMP_cyt_deam_1 PF00383.17 CCF38875.1 - 4.8e-15 55.0 0.3 6.2e-15 54.7 0.2 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.6 CCF38875.1 - 8.1e-11 42.0 0.5 1.3e-09 38.0 0.0 2.1 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.1 CCF38875.1 - 0.0031 16.9 1.8 0.28 10.5 0.0 2.1 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases adh_short_C2 PF13561.1 CCF38876.1 - 3.7e-13 49.7 0.0 8.9e-13 48.5 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF38876.1 - 3.4e-12 46.6 0.0 8.5e-12 45.2 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF38876.1 - 0.0038 16.9 0.0 0.025 14.2 0.0 2.2 2 1 0 2 2 2 1 KR domain DnaJ PF00226.26 CCF38877.1 - 1.2e-25 88.9 2.7 2.5e-25 88.0 1.9 1.5 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 CCF38877.1 - 1.1e-20 73.2 0.1 2.7e-17 62.4 0.0 2.8 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 CCF38877.1 - 2.3e-13 49.9 19.8 4.2e-13 49.1 13.7 1.4 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 CCF38877.1 - 0.019 14.6 9.5 0.14 11.8 1.6 2.4 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family zinc-ribbons_6 PF07191.7 CCF38877.1 - 0.19 11.5 6.2 1.9 8.3 1.2 2.4 2 0 0 2 2 2 0 zinc-ribbons zf-RING_3 PF14369.1 CCF38877.1 - 0.23 11.4 2.7 27 4.8 0.1 3.3 3 0 0 3 3 3 0 zinc-finger DUF2614 PF11023.3 CCF38877.1 - 0.71 9.6 5.4 6 6.6 0.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2614) Fungal_trans_2 PF11951.3 CCF38878.1 - 6e-06 25.0 0.0 8.3e-06 24.6 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF38878.1 - 0.00077 19.3 10.4 0.0013 18.5 7.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain COesterase PF00135.23 CCF38879.1 - 3.9e-91 306.3 0.0 9.2e-91 305.1 0.0 1.5 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF38879.1 - 4.4e-06 26.4 0.1 3.5e-05 23.4 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold peroxidase PF00141.18 CCF38880.1 - 1.5e-13 50.8 0.0 4.4e-13 49.2 0.0 1.7 2 0 0 2 2 2 1 Peroxidase MARVEL PF01284.18 CCF38882.1 - 8.1e-23 80.8 16.2 9.4e-23 80.6 11.3 1.0 1 0 0 1 1 1 1 Membrane-associating domain p450 PF00067.17 CCF38883.1 - 1.3e-59 202.0 0.0 2.7e-59 200.9 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 DUF2520 PF10728.4 CCF38883.1 - 0.033 13.6 0.0 0.061 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2520) Methyltransf_23 PF13489.1 CCF38884.1 - 4e-06 26.6 0.0 6.8e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF38884.1 - 3.7e-05 24.2 0.0 9.4e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF38884.1 - 0.0013 18.3 0.0 0.003 17.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_16 PF10294.4 CCF38884.1 - 0.0014 18.1 0.0 0.002 17.6 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.8 CCF38884.1 - 0.0036 16.4 0.0 0.0053 15.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.13 CCF38884.1 - 0.0063 15.7 0.0 0.0098 15.1 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_11 PF08241.7 CCF38884.1 - 0.016 15.6 0.0 0.03 14.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.14 CCF38884.1 - 0.027 14.4 0.0 0.041 13.8 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_12 PF08242.7 CCF38884.1 - 0.04 14.3 0.0 0.092 13.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 CCF38884.1 - 0.066 12.5 0.0 0.089 12.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.12 CCF38884.1 - 0.1 11.6 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase AMP-binding PF00501.23 CCF38885.1 - 1.3e-36 125.9 0.0 7.8e-36 123.3 0.0 1.9 1 1 0 1 1 1 1 AMP-binding enzyme Se-cys_synth_N PF12390.3 CCF38886.1 - 2.2 8.4 4.9 4.9 7.3 3.4 1.6 1 1 0 1 1 1 0 Selenocysteine synthase N terminal Epimerase PF01370.16 CCF38887.1 - 0.0041 16.5 0.0 0.0085 15.5 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Cu_bind_like PF02298.12 CCF38888.1 - 0.00039 20.1 0.0 0.00061 19.5 0.0 1.3 1 0 0 1 1 1 1 Plastocyanin-like domain CASP_C PF08172.7 CCF38889.1 - 0.019 14.0 0.1 0.024 13.6 0.1 1.2 1 1 0 1 1 1 0 CASP C terminal NYD-SP28_assoc PF14775.1 CCF38889.1 - 0.069 12.8 1.8 0.11 12.2 1.3 1.3 1 0 0 1 1 1 0 Sperm tail C-terminal domain 2-Hacid_dh_C PF02826.14 CCF38891.1 - 9.6e-57 190.9 0.0 1.8e-56 190.0 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 CCF38891.1 - 9.2e-22 76.9 0.0 1e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 CCF38891.1 - 1.2e-05 25.1 0.0 2.3e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 CCF38891.1 - 0.043 14.2 0.2 0.15 12.4 0.0 2.1 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Ank_2 PF12796.2 CCF38892.1 - 1.3e-21 76.7 0.9 1.1e-07 32.1 0.0 4.6 2 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.1 CCF38892.1 - 8.7e-21 73.4 3.2 5.9e-06 26.3 0.0 6.6 3 3 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.25 CCF38892.1 - 5.5e-18 63.7 4.5 4.9e-05 22.9 0.1 6.7 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.1 CCF38892.1 - 7.7e-15 53.5 1.5 0.019 15.1 0.0 7.3 7 0 0 7 7 7 3 Ankyrin repeat Ank_4 PF13637.1 CCF38892.1 - 1.4e-14 54.0 1.8 0.019 15.4 0.0 5.5 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Zn_clus PF00172.13 CCF38892.1 - 3.3 7.6 7.4 6.9 6.6 5.1 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-CSL PF05207.8 CCF38894.1 - 0.069 12.6 0.1 0.14 11.6 0.1 1.4 1 0 0 1 1 1 0 CSL zinc finger FMO-like PF00743.14 CCF38895.1 - 3.6e-24 84.8 0.0 3e-11 42.2 0.0 3.1 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 CCF38895.1 - 4.5e-20 72.5 0.0 4.4e-19 69.3 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF38895.1 - 2.1e-09 36.7 0.3 9.5e-07 28.0 0.1 2.3 2 1 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 CCF38895.1 - 5e-08 33.0 0.0 0.00044 20.1 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF38895.1 - 6e-08 32.6 0.1 5.8e-05 22.9 0.0 2.7 3 0 0 3 3 3 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 CCF38895.1 - 7.6e-07 29.0 0.0 3.3e-06 27.0 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 CCF38895.1 - 0.0089 15.1 0.1 0.029 13.4 0.0 1.7 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.22 CCF38895.1 - 0.017 15.5 0.2 0.8 10.1 0.0 2.8 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF38895.1 - 0.032 13.1 0.0 1 8.2 0.0 2.3 2 1 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.9 CCF38895.1 - 0.083 11.3 0.0 0.16 10.4 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein OCD_Mu_crystall PF02423.10 CCF38895.1 - 0.2 10.3 0.0 0.29 9.8 0.0 1.2 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family MFS_1 PF07690.11 CCF38896.1 - 2.5e-11 42.9 21.2 3.9e-11 42.2 14.7 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 CCF38896.1 - 1.5e-05 24.5 2.1 3.6e-05 23.2 1.5 1.7 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.19 CCF38896.1 - 0.025 13.1 12.4 0.065 11.8 8.6 1.7 1 1 0 1 1 1 0 Sugar (and other) transporter ADH_N PF08240.7 CCF38897.1 - 1.7e-29 101.7 2.6 3e-29 100.9 1.8 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF38897.1 - 1.5e-28 98.9 1.5 5.5e-28 97.1 0.2 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF38897.1 - 3.9e-06 27.7 0.1 8e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.16 CCF38897.1 - 0.0014 18.2 2.9 0.0018 17.8 0.6 2.0 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Methyltransf_18 PF12847.2 CCF38897.1 - 0.0027 18.2 0.1 0.011 16.2 0.1 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF38897.1 - 0.022 15.2 0.0 0.049 14.1 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Pyr_redox_2 PF07992.9 CCF38897.1 - 0.038 13.8 0.9 0.075 12.9 0.4 1.6 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_26 PF13659.1 CCF38897.1 - 0.039 13.9 0.2 0.78 9.7 0.1 2.4 1 1 0 1 1 1 0 Methyltransferase domain PPR PF01535.15 CCF38897.1 - 0.043 13.7 0.1 0.34 10.9 0.0 2.3 2 0 0 2 2 2 0 PPR repeat Methyltransf_25 PF13649.1 CCF38897.1 - 0.096 13.0 0.0 0.27 11.6 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain YdfZ PF14001.1 CCF38897.1 - 0.26 11.5 1.4 2.2 8.5 0.1 2.7 3 0 0 3 3 3 0 YdfZ protein Ribonuc_L-PSP PF01042.16 CCF38898.1 - 9.2e-22 77.0 0.0 1.1e-21 76.8 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Spore_YpjB PF09577.5 CCF38898.1 - 0.11 12.0 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 Sporulation protein YpjB (SpoYpjB) Aldedh PF00171.17 CCF38899.1 - 2.7e-161 537.0 3.0 2.9e-116 388.5 0.4 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family MOSC_N PF03476.11 CCF38900.1 - 4.5e-10 39.2 0.0 8.4e-09 35.1 0.0 2.3 1 1 0 1 1 1 1 MOSC N-terminal beta barrel domain Cyt-b5 PF00173.23 CCF38901.1 - 1.7e-24 85.3 0.1 2.2e-24 85.0 0.1 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TFIIE_beta PF02186.10 CCF38902.1 - 0.00032 20.6 0.0 0.00079 19.3 0.0 1.7 1 0 0 1 1 1 1 TFIIE beta subunit core domain Malate_DH PF12434.3 CCF38902.1 - 0.77 9.5 5.0 13 5.5 0.1 2.9 2 0 0 2 2 2 0 Malate dehydrogenase enzyme DSBA PF01323.15 CCF38903.1 - 2.5e-34 118.5 0.0 2.9e-34 118.3 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.1 CCF38903.1 - 2.4e-07 30.8 0.0 3.7e-05 23.7 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_3 PF13192.1 CCF38903.1 - 0.094 12.5 0.0 7.6 6.4 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin domain Thioredoxin_2 PF13098.1 CCF38903.1 - 0.12 12.5 0.0 2.5 8.3 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin-like domain Glyco_hydro_61 PF03443.9 CCF38904.1 - 2e-74 250.0 0.1 2e-74 250.0 0.1 1.8 2 1 0 2 2 2 1 Glycosyl hydrolase family 61 CBM_1 PF00734.13 CCF38904.1 - 1e-17 63.4 17.4 5.8e-09 35.4 2.6 2.6 2 0 0 2 2 2 2 Fungal cellulose binding domain DDE_1 PF03184.14 CCF38905.1 - 3.8e-53 179.8 0.0 6.9e-53 178.9 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 CCF38905.1 - 1.3e-10 40.8 0.1 3.9e-10 39.4 0.0 1.9 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF38905.1 - 3.9e-09 35.8 0.0 7.6e-09 34.9 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.1 CCF38905.1 - 0.031 13.9 0.9 0.17 11.5 0.0 2.6 2 0 0 2 2 2 0 Homeodomain-like domain Inhibitor_I9 PF05922.11 CCF38907.1 - 0.00013 22.4 0.4 0.0002 21.8 0.3 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I9 Pkinase PF00069.20 CCF38908.1 - 4.2e-20 71.9 0.0 6.9e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF38908.1 - 1.9e-09 36.9 0.2 1.1e-08 34.5 0.1 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Glyco_hydro_25 PF01183.15 CCF38908.1 - 0.045 13.5 0.0 0.072 12.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 25 DUF1604 PF07713.8 CCF38909.1 - 5e-39 131.9 1.4 2.8e-37 126.3 0.7 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1604) G-patch PF01585.18 CCF38909.1 - 4.4e-06 26.3 1.2 1.5e-05 24.6 0.3 2.3 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.2 CCF38909.1 - 0.002 17.9 2.2 0.0041 16.9 0.4 2.5 2 1 0 2 2 2 1 DExH-box splicing factor binding site Rhomboid_SP PF12595.3 CCF38910.1 - 0.11 12.1 1.0 0.12 11.9 0.7 1.0 1 0 0 1 1 1 0 Rhomboid serine protease Cu-oxidase_3 PF07732.10 CCF38911.1 - 1.4e-41 140.9 2.2 5.6e-40 135.7 1.0 2.3 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.17 CCF38911.1 - 4e-25 88.5 0.1 8.7e-25 87.4 0.1 1.5 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 CCF38911.1 - 0.00083 18.8 4.6 0.071 12.6 1.6 3.5 3 1 0 3 3 3 1 Multicopper oxidase zf-C3HC4_2 PF13923.1 CCF38913.1 - 0.00068 19.6 2.7 0.0016 18.4 1.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF38913.1 - 0.0078 16.0 3.0 0.017 14.9 2.1 1.6 1 0 0 1 1 1 1 Ring finger domain DUF4428 PF14471.1 CCF38913.1 - 1.3 8.8 3.8 1.8 8.3 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) zf-C3HC4_3 PF13920.1 CCF38913.1 - 1.9 8.2 5.1 5.9 6.6 3.5 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Tim54 PF11711.3 CCF38914.1 - 3.8e-32 111.3 0.0 3.8e-32 111.3 0.0 1.3 2 0 0 2 2 2 1 Inner membrane protein import complex subunit Tim54 Med15 PF09606.5 CCF38915.1 - 0.27 9.3 40.0 0.31 9.1 27.7 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal FCP1_C PF09309.5 CCF38915.1 - 1.2 8.4 7.5 1.9 7.7 5.2 1.4 1 0 0 1 1 1 0 FCP1, C-terminal PAT1 PF09770.4 CCF38915.1 - 1.5 6.9 35.0 1.7 6.8 24.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 CCF38915.1 - 3.1 7.6 19.2 3.3 7.4 13.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4175 PF13779.1 CCF38915.1 - 4 5.0 21.7 4.7 4.7 15.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Suf PF05843.9 CCF38915.1 - 9.8 5.8 8.6 12 5.4 6.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3328 PF11807.3 CCF38917.1 - 8.3e-08 32.1 0.0 1.2e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) HTH_psq PF05225.11 CCF38917.1 - 0.076 12.5 0.0 0.21 11.1 0.0 1.8 1 0 0 1 1 1 0 helix-turn-helix, Psq domain EVC2_like PF12297.3 CCF38918.1 - 0.0044 15.7 0.0 0.0061 15.2 0.0 1.1 1 0 0 1 1 1 1 Ellis van Creveld protein 2 like protein SKG6 PF08693.5 CCF38918.1 - 0.008 15.4 0.4 0.022 14.0 0.3 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM154 PF15102.1 CCF38918.1 - 0.13 11.9 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family Granulin PF00396.13 CCF38918.1 - 5.2 7.2 26.0 0.27 11.3 2.9 3.4 2 1 1 3 3 3 0 Granulin Peptidase_M3 PF01432.15 CCF38919.1 - 7e-122 407.7 0.0 9e-122 407.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.1 CCF38919.1 - 0.092 12.1 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Peptidase M50B-like ApoO PF09769.4 CCF38920.1 - 1.8e-48 164.2 0.2 2.9e-47 160.3 0.0 2.1 2 0 0 2 2 2 1 Apolipoprotein O Dus PF01207.12 CCF38921.1 - 2.8e-43 147.9 0.3 1.2e-42 145.8 0.2 1.8 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) Pyrophosphatase PF00719.14 CCF38922.1 - 3.1e-52 176.1 0.1 3.9e-52 175.8 0.1 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase SEN1_N PF12726.2 CCF38923.1 - 4.6e-16 58.0 0.1 5.5e-16 57.7 0.0 1.1 1 0 0 1 1 1 1 SEN1 N terminal FAM212 PF15342.1 CCF38923.1 - 0.12 11.9 0.2 0.25 10.9 0.1 1.5 1 0 0 1 1 1 0 FAM212 family DSS1_SEM1 PF05160.8 CCF38923.1 - 0.39 10.5 4.5 0.29 10.9 0.7 2.3 2 0 0 2 2 2 0 DSS1/SEM1 family HhH-GPD PF00730.20 CCF38925.1 - 6e-11 42.5 0.0 1.8e-10 41.0 0.0 1.8 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein DnaJ PF00226.26 CCF38926.1 - 0.0013 18.4 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Mito_carr PF00153.22 CCF38927.1 - 3e-73 241.6 5.6 2.4e-25 88.0 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein zf-ribbon_3 PF13248.1 CCF38928.1 - 0.002 17.2 5.7 0.002 17.2 4.0 2.0 1 1 1 2 2 2 1 zinc-ribbon domain HypA PF01155.14 CCF38928.1 - 0.011 15.4 3.0 0.013 15.2 2.1 1.1 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family DUF3725 PF12523.3 CCF38928.1 - 0.24 11.5 0.2 0.24 11.5 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3725) zf-B_box PF00643.19 CCF38928.1 - 0.39 10.6 10.9 5.6 6.9 7.8 2.0 1 1 1 2 2 2 0 B-box zinc finger DZR PF12773.2 CCF38928.1 - 0.56 10.0 9.7 7.4 6.4 6.7 2.2 1 1 0 1 1 1 0 Double zinc ribbon DUF3279 PF11682.3 CCF38928.1 - 1.1 8.8 6.6 1.6 8.3 4.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3279) Ribosomal_L33 PF00471.15 CCF38928.1 - 3.5 7.9 6.4 0.67 10.2 0.8 2.1 1 1 1 2 2 2 0 Ribosomal protein L33 zf-RanBP PF00641.13 CCF38928.1 - 4.5 6.4 8.6 2.3 7.3 1.6 2.4 2 1 0 2 2 2 0 Zn-finger in Ran binding protein and others DUF4379 PF14311.1 CCF38928.1 - 5.5 6.8 12.5 1.3 8.8 4.4 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4379) Dynactin_p62 PF05502.8 CCF38928.1 - 6.8 5.3 8.0 0.55 8.9 2.6 1.3 2 0 0 2 2 2 0 Dynactin p62 family Homeobox_KN PF05920.6 CCF38929.1 - 2.6e-13 49.4 2.3 6.9e-13 48.0 1.6 1.8 1 0 0 1 1 1 1 Homeobox KN domain zf-C2H2 PF00096.21 CCF38929.1 - 2.6e-08 33.7 21.7 0.0027 17.9 2.9 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF38929.1 - 5.2e-06 26.4 20.9 0.015 15.6 3.2 4.5 3 1 0 3 3 3 3 C2H2-type zinc finger Homeobox PF00046.24 CCF38929.1 - 3.4e-05 23.3 1.7 8e-05 22.1 1.2 1.6 1 0 0 1 1 1 1 Homeobox domain Homez PF11569.3 CCF38929.1 - 0.021 13.8 0.0 0.042 12.9 0.0 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez A2L_zn_ribbon PF08792.5 CCF38929.1 - 0.049 13.0 5.6 0.48 9.9 0.2 3.1 3 0 0 3 3 3 0 A2L zinc ribbon domain zf-C2H2_2 PF12756.2 CCF38929.1 - 0.63 10.1 6.8 10 6.3 0.1 3.3 2 1 0 3 3 3 0 C2H2 type zinc-finger (2 copies) MFS_1 PF07690.11 CCF38930.1 - 9.9e-41 139.6 41.1 9.9e-41 139.6 28.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily R3H PF01424.17 CCF38931.1 - 1.5e-13 50.1 0.0 3.4e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 R3H domain G-patch PF01585.18 CCF38931.1 - 1e-11 44.4 0.8 2.7e-11 43.0 0.5 1.8 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 CCF38931.1 - 0.0072 16.1 0.7 0.0072 16.1 0.5 2.5 2 0 0 2 2 2 1 DExH-box splicing factor binding site Histone PF00125.19 CCF38932.1 - 1.8e-22 79.2 0.2 2.5e-22 78.7 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 CCF38932.1 - 2e-05 24.5 0.0 5.3e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 CCF38932.1 - 0.00027 21.1 0.0 0.00046 20.4 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A RP-C PF03428.8 CCF38932.1 - 0.012 15.0 0.1 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 Replication protein C N-terminal domain DUF1018 PF06252.7 CCF38932.1 - 0.033 14.7 0.5 0.044 14.3 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) Totivirus_coat PF05518.6 CCF38933.1 - 4.1 5.1 12.3 4.4 5.0 8.5 1.0 1 0 0 1 1 1 0 Totivirus coat protein Cation_efflux PF01545.16 CCF38935.1 - 1.9e-81 273.2 1.8 5e-81 271.9 1.3 1.6 1 1 0 1 1 1 1 Cation efflux family HABP4_PAI-RBP1 PF04774.10 CCF38936.1 - 1.1 9.8 9.8 0.049 14.1 2.4 1.9 2 0 0 2 2 2 0 Hyaluronan / mRNA binding family SAPS PF04499.10 CCF38937.1 - 1.5e-195 650.4 0.0 4.2e-195 648.9 0.0 1.8 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein p450 PF00067.17 CCF38938.1 - 1.4e-67 228.2 0.0 1.5e-67 228.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PPR_3 PF13812.1 CCF38939.1 - 3.1e-05 23.8 0.0 0.0018 18.4 0.0 3.8 4 0 0 4 4 4 1 Pentatricopeptide repeat domain PPR_2 PF13041.1 CCF38939.1 - 0.00032 20.6 0.0 3.9 7.5 0.0 4.5 4 0 0 4 4 4 1 PPR repeat family PPR PF01535.15 CCF38939.1 - 0.0023 17.7 0.0 7.6 6.7 0.0 3.9 3 0 0 3 3 3 2 PPR repeat Ribosomal_S18 PF01084.15 CCF38940.1 - 1e-10 41.3 0.0 2.2e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S18 S4 PF01479.20 CCF38941.1 - 1.5e-11 43.5 0.0 3.7e-11 42.2 0.0 1.7 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.14 CCF38941.1 - 1e-10 41.8 1.6 1.6e-10 41.2 0.7 1.6 2 0 0 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain Glyco_hydro_61 PF03443.9 CCF38942.1 - 9.3e-75 251.1 0.0 1.1e-74 250.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 NPCBM_assoc PF10633.4 CCF38942.1 - 0.049 13.6 0.1 0.33 11.0 0.0 2.1 2 0 0 2 2 2 0 NPCBM-associated, NEW3 domain of alpha-galactosidase DUF2462 PF09495.5 CCF38943.1 - 1.4e-11 44.9 11.0 1.4e-11 44.9 7.7 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF2462) DUF4588 PF15251.1 CCF38945.1 - 0.0013 18.7 16.2 0.056 13.4 11.2 2.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4588) AKAP2_C PF15304.1 CCF38945.1 - 0.041 13.4 9.3 0.051 13.1 6.4 1.4 1 1 0 1 1 1 0 A-kinase anchor protein 2 C-terminus SNF2_N PF00176.18 CCF38946.1 - 4e-82 275.3 0.2 7.7e-82 274.4 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.5 CCF38946.1 - 1.6e-44 150.4 1.6 6.3e-44 148.4 1.0 2.2 2 0 0 2 2 2 1 SLIDE HAND PF09110.6 CCF38946.1 - 3.3e-33 114.4 5.5 3.3e-33 114.4 3.8 3.8 3 0 0 3 3 3 1 HAND Helicase_C PF00271.26 CCF38946.1 - 6.9e-14 51.4 0.1 3.7e-13 49.1 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF38946.1 - 2.2e-08 34.1 3.2 3.8e-08 33.3 0.0 3.2 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.24 CCF38946.1 - 0.00022 20.7 0.0 0.00049 19.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Myb_DNA-binding PF00249.26 CCF38946.1 - 0.021 14.8 0.0 1.7 8.7 0.0 3.5 2 0 0 2 2 2 0 Myb-like DNA-binding domain DEAD_2 PF06733.10 CCF38946.1 - 0.028 13.8 0.1 0.061 12.7 0.0 1.5 1 0 0 1 1 1 0 DEAD_2 WavE PF07507.6 CCF38947.1 - 0.12 11.2 0.0 0.12 11.2 0.0 1.0 1 0 0 1 1 1 0 WavE lipopolysaccharide synthesis WD40 PF00400.27 CCF38948.1 - 3e-48 160.0 29.8 1e-08 34.7 0.1 10.8 11 0 0 11 11 11 9 WD domain, G-beta repeat CPSF_A PF03178.10 CCF38948.1 - 4.7e-05 22.6 0.0 0.00034 19.8 0.0 2.1 2 0 0 2 2 2 1 CPSF A subunit region PD40 PF07676.7 CCF38948.1 - 0.096 12.3 0.0 11 5.8 0.0 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Glyco_tran_28_C PF04101.11 CCF38949.1 - 7.2e-17 61.5 0.0 2.1e-16 60.0 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 CCF38949.1 - 0.00013 21.2 0.0 0.00042 19.6 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 1 UDPGT PF00201.13 CCF38949.1 - 0.13 10.7 0.1 0.18 10.3 0.0 1.1 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase FtsX PF02687.16 CCF38950.1 - 1.1 9.0 6.3 0.45 10.2 2.5 1.6 2 0 0 2 2 2 0 FtsX-like permease family Ank_2 PF12796.2 CCF38951.1 - 5.9e-67 222.0 16.0 6.2e-18 64.9 0.0 6.6 3 1 4 7 7 7 7 Ankyrin repeats (3 copies) Ank PF00023.25 CCF38951.1 - 2.3e-52 172.2 13.6 1.6e-05 24.4 0.0 12.8 13 0 0 13 13 13 9 Ankyrin repeat Ank_4 PF13637.1 CCF38951.1 - 1.6e-45 152.6 4.2 3.9e-07 30.4 0.0 9.9 6 2 4 10 10 10 9 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF38951.1 - 4.2e-43 141.0 5.5 0.0002 21.2 0.0 12.9 13 0 0 13 13 12 8 Ankyrin repeat Ank_5 PF13857.1 CCF38951.1 - 2.1e-39 132.6 12.6 6.1e-06 26.3 0.2 11.2 3 3 9 12 12 12 10 Ankyrin repeats (many copies) AAA_16 PF13191.1 CCF38951.1 - 8e-07 29.2 0.4 5.9e-06 26.3 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain Abhydrolase_6 PF12697.2 CCF38951.1 - 4.3e-05 23.4 0.0 0.00028 20.8 0.0 2.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family AAA_22 PF13401.1 CCF38951.1 - 0.0003 20.9 0.4 0.0014 18.7 0.0 2.3 3 0 0 3 3 2 1 AAA domain DUF676 PF05057.9 CCF38951.1 - 0.00056 19.2 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.8 CCF38951.1 - 0.00067 19.3 0.0 0.0014 18.2 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.2 CCF38951.1 - 0.0016 18.2 0.0 0.0062 16.2 0.0 2.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.20 CCF38951.1 - 0.0067 16.0 0.0 0.02 14.5 0.0 1.8 1 0 0 1 1 1 1 Lipase (class 3) Thioesterase PF00975.15 CCF38951.1 - 0.008 16.4 1.4 0.56 10.3 0.0 3.5 3 0 0 3 3 3 1 Thioesterase domain Cutinase PF01083.17 CCF38951.1 - 0.044 13.5 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Cutinase MRP-S28 PF10213.4 CCF38952.1 - 1.3e-47 161.0 1.0 2.6e-47 160.0 0.7 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein TFR_dimer PF04253.10 CCF38954.1 - 1.3e-20 73.1 0.0 2e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.12 CCF38954.1 - 7.3e-13 48.6 0.0 1.4e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 CCF38954.1 - 4.8e-08 32.6 0.2 1.1e-07 31.5 0.2 1.6 1 0 0 1 1 1 1 PA domain Nicastrin PF05450.10 CCF38954.1 - 0.061 12.5 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Nicastrin DUF3439 PF11921.3 CCF38954.1 - 1 9.1 4.3 1.9 8.2 3.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF4246 PF14033.1 CCF38956.1 - 1.3e-173 578.2 0.4 1.5e-173 578.0 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) HTH_29 PF13551.1 CCF38956.1 - 0.072 13.2 0.1 0.95 9.6 0.0 2.5 2 0 0 2 2 2 0 Winged helix-turn helix RTA1 PF04479.8 CCF38957.1 - 2.3e-31 109.0 1.3 3.8e-31 108.3 0.9 1.2 1 0 0 1 1 1 1 RTA1 like protein DUF2784 PF10861.3 CCF38957.1 - 0.04 13.7 2.7 0.054 13.2 0.8 2.1 2 0 0 2 2 2 0 Protein of Unknown function (DUF2784) Epimerase PF01370.16 CCF38958.1 - 1.9e-24 86.3 0.0 2.7e-24 85.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF38958.1 - 2.2e-13 49.5 0.0 3.1e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 CCF38958.1 - 2.7e-10 39.5 0.0 1.2e-07 30.9 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.12 CCF38958.1 - 5.3e-10 38.6 0.0 6.2e-10 38.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.1 CCF38958.1 - 1.1e-07 32.1 0.0 2.3e-07 30.9 0.0 1.6 1 1 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 CCF38958.1 - 1.5e-06 27.2 0.0 6.8e-06 25.1 0.0 1.8 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.5 CCF38958.1 - 0.00013 21.6 0.3 0.039 13.6 0.0 2.2 2 0 0 2 2 2 2 KR domain adh_short PF00106.20 CCF38958.1 - 0.0003 20.7 1.3 0.036 14.0 1.2 3.0 2 1 0 2 2 2 1 short chain dehydrogenase FTA4 PF13093.1 CCF38959.1 - 7.4e-23 81.1 0.0 8.7e-23 80.8 0.0 1.0 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF2306 PF10067.4 CCF38960.1 - 4.8e-08 33.0 9.0 4.8e-08 33.0 6.2 2.0 2 0 0 2 2 2 1 Predicted membrane protein (DUF2306) Fn3-like PF14310.1 CCF38961.1 - 1.7e-25 88.7 0.7 2.4e-25 88.2 0.5 1.2 1 0 0 1 1 1 1 Fibronectin type III-like domain CARDB PF07705.6 CCF38961.1 - 0.023 14.7 0.5 0.036 14.1 0.3 1.4 1 1 0 1 1 1 0 CARDB BiPBP_C PF06832.7 CCF38961.1 - 0.049 13.5 0.0 0.24 11.3 0.0 2.0 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family DUF2393 PF09624.5 CCF38961.1 - 0.061 12.8 0.0 0.088 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2393) DUF1034 PF06280.7 CCF38961.1 - 0.19 12.1 1.7 1.2 9.5 0.7 2.4 1 1 1 2 2 2 0 Fn3-like domain (DUF1034) CLN3 PF02487.12 CCF38962.1 - 5.9e-34 117.5 9.6 1.9e-26 92.7 1.0 2.0 1 1 1 2 2 2 2 CLN3 protein EmrE PF13536.1 CCF38962.1 - 0.37 11.0 6.3 0.27 11.4 3.5 1.4 1 1 0 1 1 1 0 Multidrug resistance efflux transporter DUF4282 PF14110.1 CCF38962.1 - 1.9 8.7 5.7 0.44 10.7 0.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) Acetyltransf_8 PF13523.1 CCF38963.1 - 4.7e-27 94.7 0.0 7.3e-27 94.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF607 PF04678.8 CCF38964.1 - 9.8e-09 35.3 1.1 9.9e-09 35.3 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function, DUF607 U79_P34 PF03064.11 CCF38964.1 - 0.0039 16.7 7.6 0.0046 16.5 5.3 1.2 1 0 0 1 1 1 1 HSV U79 / HCMV P34 Vfa1 PF08432.5 CCF38964.1 - 3.8 7.4 11.0 5 7.1 7.6 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 THOC7 PF05615.8 CCF38967.1 - 1.5e-35 122.4 4.9 1.5e-35 122.4 3.4 1.9 1 1 1 2 2 2 1 Tho complex subunit 7 Herpes_UL17 PF04559.7 CCF38967.1 - 0.06 11.9 0.8 0.076 11.5 0.5 1.2 1 0 0 1 1 1 0 Herpesvirus UL17 protein RTBV_P46 PF06216.6 CCF38967.1 - 0.12 11.2 8.3 0.03 13.1 1.2 2.1 1 1 1 2 2 2 0 Rice tungro bacilliform virus P46 protein Bacillus_HBL PF05791.6 CCF38967.1 - 1.6 8.0 5.9 0.72 9.2 0.9 2.2 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Sec66 PF09802.4 CCF38967.1 - 2.7 7.3 10.5 3.1 7.1 1.5 2.1 2 0 0 2 2 2 0 Preprotein translocase subunit Sec66 DUF972 PF06156.8 CCF38967.1 - 3.4 8.0 14.2 1.2 9.5 2.4 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF972) zf-C4H2 PF10146.4 CCF38967.1 - 4.5 7.2 12.8 0.18 11.7 3.1 2.4 1 1 2 3 3 3 0 Zinc finger-containing protein TBCA PF02970.11 CCF38968.1 - 1.4e-18 66.7 6.2 1.7e-18 66.4 4.2 1.3 1 1 0 1 1 1 1 Tubulin binding cofactor A TAP42 PF04177.7 CCF38968.1 - 0.025 13.5 0.7 0.024 13.6 0.5 1.1 1 0 0 1 1 1 0 TAP42-like family ApoLp-III PF07464.6 CCF38968.1 - 0.32 11.0 4.1 0.37 10.8 2.9 1.2 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) DUF3166 PF11365.3 CCF38968.1 - 0.6 10.5 4.9 0.8 10.2 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3166) DUF4404 PF14357.1 CCF38968.1 - 0.69 10.3 3.4 0.77 10.2 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) Abhydrolase_6 PF12697.2 CCF38969.1 - 1.5e-25 90.4 4.2 1.8e-25 90.1 2.9 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF38969.1 - 2.6e-14 53.1 0.2 3.6e-14 52.7 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF38969.1 - 8.9e-05 22.1 0.0 0.0014 18.2 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Thioesterase PF00975.15 CCF38969.1 - 0.00019 21.7 0.2 0.00024 21.4 0.2 1.3 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.8 CCF38969.1 - 0.015 14.9 0.0 0.046 13.3 0.0 1.7 2 0 0 2 2 2 0 PGAP1-like protein DUF900 PF05990.7 CCF38969.1 - 0.044 13.1 0.0 0.066 12.5 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) RRM_1 PF00076.17 CCF38970.1 - 6.8e-12 44.8 0.0 9.6e-12 44.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF38970.1 - 5e-08 32.8 0.0 7.7e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF38970.1 - 6e-07 29.2 0.0 8.5e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CCF38970.1 - 0.00036 20.2 0.0 0.00073 19.2 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Topoisom_bac PF01131.15 CCF38971.1 - 2.6e-64 217.5 0.0 3e-64 217.3 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.17 CCF38971.1 - 7.5e-19 67.5 0.0 1.4e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 Toprim domain Toprim_4 PF13662.1 CCF38971.1 - 0.11 12.5 0.0 1.5 8.8 0.0 2.3 2 0 0 2 2 2 0 Toprim domain DUF1295 PF06966.7 CCF38972.1 - 9.7e-36 123.2 10.9 1.2e-35 122.9 7.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.9 CCF38972.1 - 0.013 15.6 2.2 0.12 12.6 0.2 2.7 2 1 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Hydrolase_like PF13242.1 CCF38973.1 - 8.8e-13 47.7 0.1 1.1e-12 47.4 0.1 1.1 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 CCF38973.1 - 0.0053 17.1 0.0 0.0072 16.7 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase APCDDC PF14921.1 CCF38973.1 - 0.15 11.3 0.0 0.15 11.3 0.0 1.0 1 0 0 1 1 1 0 Adenomatosis polyposis coli down-regulated 1 GDA1_CD39 PF01150.12 CCF38974.1 - 4.1e-101 338.6 0.0 5.6e-101 338.1 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family DUF775 PF05603.7 CCF38975.1 - 1.7e-50 171.3 0.0 2e-50 171.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) NUDIX PF00293.23 CCF38976.1 - 8.2e-11 41.6 0.0 1.3e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain RNA_pol_Rpb8 PF03870.10 CCF38977.1 - 5.8e-39 133.4 0.2 6.5e-39 133.2 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 PAXNEB PF05625.6 CCF38978.1 - 9.4e-93 310.9 0.0 1e-92 310.7 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein tRNA_int_endo PF01974.12 CCF38979.1 - 3.9e-15 55.4 0.0 7.2e-15 54.5 0.0 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain ING PF12998.2 CCF38979.1 - 0.053 13.7 0.1 0.085 13.1 0.1 1.2 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding zf-C3HC4_3 PF13920.1 CCF38980.1 - 4.8e-08 32.5 12.8 7.9e-08 31.8 8.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FAM24 PF15193.1 CCF38980.1 - 2.5 8.3 9.3 4.9 7.4 6.5 1.4 1 0 0 1 1 1 0 FAM24 family Abhydrolase_3 PF07859.8 CCF38981.1 - 2.7e-43 148.0 0.0 3.8e-43 147.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 CCF38981.1 - 7.2e-08 31.5 0.1 4.2e-07 29.0 0.1 1.9 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_5 PF12695.2 CCF38981.1 - 1.4e-05 24.8 0.0 1.9e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.7 CCF38981.1 - 0.0098 14.4 0.1 2.4 6.5 0.0 2.1 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) Abhydrolase_2 PF02230.11 CCF38981.1 - 0.021 14.2 0.0 0.043 13.2 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase DUF829 PF05705.9 CCF38981.1 - 0.038 13.6 0.0 0.15 11.7 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF829) Esterase PF00756.15 CCF38981.1 - 0.041 13.2 0.0 3.9 6.8 0.0 2.4 2 0 0 2 2 2 0 Putative esterase Peptidase_S9 PF00326.16 CCF38981.1 - 0.052 12.7 0.0 0.15 11.2 0.0 1.7 1 0 0 1 1 1 0 Prolyl oligopeptidase family Thioesterase PF00975.15 CCF38981.1 - 0.13 12.4 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain His_Phos_2 PF00328.17 CCF38982.1 - 1.1e-09 38.0 0.1 2.8e-09 36.7 0.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) GATase_3 PF07685.9 CCF38982.1 - 0.048 13.2 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Marek_A PF02124.10 CCF38982.1 - 0.1 12.0 0.2 0.18 11.2 0.1 1.3 1 0 0 1 1 1 0 Marek's disease glycoprotein A DHDPS PF00701.17 CCF38983.1 - 9.2e-51 172.1 0.0 1e-50 171.9 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family PEP_mutase PF13714.1 CCF38983.1 - 0.00039 19.7 0.0 0.00064 19.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase HEAT PF02985.17 CCF38984.1 - 1.2e-17 62.3 3.2 0.00074 19.3 0.1 7.9 8 0 0 8 8 8 4 HEAT repeat HEAT_EZ PF13513.1 CCF38984.1 - 1.1e-13 51.1 26.3 8.2e-07 29.3 0.2 10.4 9 2 3 12 12 12 4 HEAT-like repeat HEAT_2 PF13646.1 CCF38984.1 - 7.7e-13 48.5 19.8 2.7e-05 24.3 0.3 7.3 6 2 4 10 10 10 4 HEAT repeats Adaptin_N PF01602.15 CCF38984.1 - 8.5e-06 24.3 0.3 0.043 12.1 0.0 3.2 2 2 0 2 2 2 2 Adaptin N terminal region CLASP_N PF12348.3 CCF38984.1 - 1.8e-05 24.2 0.0 0.00029 20.2 0.0 2.8 2 0 0 2 2 2 1 CLASP N terminal Vac14_Fab1_bd PF12755.2 CCF38984.1 - 5.6e-05 23.4 0.0 0.16 12.3 0.0 4.2 2 1 1 3 3 3 1 Vacuolar 14 Fab1-binding region IBN_N PF03810.14 CCF38984.1 - 0.00029 20.6 4.0 0.0009 19.1 0.5 3.2 3 0 0 3 3 3 1 Importin-beta N-terminal domain UME PF08064.8 CCF38984.1 - 0.0017 18.3 0.0 1.6 8.7 0.0 4.1 4 1 0 4 4 4 1 UME (NUC010) domain Cnd1 PF12717.2 CCF38984.1 - 0.0035 17.2 0.5 4.4 7.1 0.0 4.2 5 0 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.18 CCF38984.1 - 0.016 15.0 5.4 16 5.4 0.1 5.4 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Glyco_hydro_cc PF11790.3 CCF38986.1 - 3.1e-17 62.8 0.0 3.6e-17 62.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core MFS_1 PF07690.11 CCF38987.1 - 2.4e-20 72.5 35.3 9.8e-11 40.9 6.0 3.2 3 0 0 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.1 CCF38987.1 - 6.4e-06 24.8 17.0 0.0007 18.1 3.8 2.8 3 0 0 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.2 CCF38987.1 - 0.53 10.1 6.3 0.62 9.8 0.1 3.6 4 0 0 4 4 4 0 MFS_1 like family TraL PF07178.6 CCF38987.1 - 0.98 9.4 6.3 3.6 7.6 0.0 3.3 3 0 0 3 3 3 0 TraL protein LacY_symp PF01306.14 CCF38987.1 - 6.2 5.2 15.5 0.055 12.0 3.5 2.5 3 0 0 3 3 3 0 LacY proton/sugar symporter adh_short PF00106.20 CCF38992.1 - 2.7e-18 66.4 0.4 4e-18 65.8 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF38992.1 - 1.3e-09 38.0 0.1 1.8e-09 37.5 0.1 1.2 1 0 0 1 1 1 1 KR domain Aldo_ket_red PF00248.16 CCF38993.1 - 5.5e-61 205.8 0.1 9.1e-61 205.1 0.0 1.3 2 0 0 2 2 2 1 Aldo/keto reductase family HTH_Tnp_Mu_2 PF09039.6 CCF38993.1 - 0.081 12.6 0.0 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Mu DNA binding, I gamma subdomain Zn_clus PF00172.13 CCF38994.1 - 2e-10 40.4 8.1 3.4e-10 39.6 5.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF38994.1 - 1e-07 30.8 0.0 1.6e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Nol1_Nop2_Fmu_2 PF13636.1 CCF38994.1 - 0.16 12.0 0.0 0.26 11.3 0.0 1.3 1 0 0 1 1 1 0 pre-rRNA processing and ribosome biogenesis FAD_binding_4 PF01565.18 CCF38995.1 - 2.3e-16 59.5 4.4 1.6e-15 56.8 3.1 2.3 1 1 0 1 1 1 1 FAD binding domain BBE PF08031.7 CCF38995.1 - 4.6e-09 36.0 0.0 7.8e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 Berberine and berberine like CoA_binding_2 PF13380.1 CCF38995.1 - 0.034 14.2 0.0 0.08 13.1 0.0 1.6 1 0 0 1 1 1 0 CoA binding domain Cytokin-bind PF09265.5 CCF38995.1 - 0.07 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Methyltransf_11 PF08241.7 CCF38996.1 - 1e-06 29.1 0.1 1.6e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF38996.1 - 0.00018 21.1 0.0 0.00026 20.6 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF38996.1 - 0.00036 20.9 0.0 0.0005 20.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF38996.1 - 0.00073 20.0 0.1 0.0011 19.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF38996.1 - 0.0013 18.4 0.0 0.0018 18.0 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 CCF38996.1 - 0.0016 17.4 0.0 0.0023 16.9 0.0 1.2 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family STAS_2 PF13466.1 CCF38996.1 - 0.13 12.3 0.3 0.26 11.3 0.2 1.4 1 0 0 1 1 1 0 STAS domain FAD_binding_3 PF01494.14 CCF38997.1 - 1.8e-21 76.6 0.1 2.9e-21 75.9 0.0 1.3 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF38997.1 - 7.6e-05 21.7 2.7 0.0013 17.7 0.7 2.2 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF38997.1 - 0.00085 19.3 0.2 0.0024 17.8 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF38997.1 - 0.0067 16.3 0.2 0.014 15.2 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF38997.1 - 0.018 15.1 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF38997.1 - 0.02 14.7 0.3 0.4 10.4 0.1 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding SE PF08491.5 CCF38997.1 - 0.03 13.1 0.0 0.078 11.7 0.0 1.6 2 0 0 2 2 2 0 Squalene epoxidase Pyr_redox PF00070.22 CCF38997.1 - 0.035 14.5 0.1 0.035 14.5 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF38997.1 - 0.047 12.1 0.1 0.067 11.6 0.1 1.1 1 0 0 1 1 1 0 HI0933-like protein GIDA PF01134.17 CCF38997.1 - 0.064 12.1 0.0 0.086 11.6 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A 3HCDH_N PF02737.13 CCF38997.1 - 0.17 11.5 0.1 0.35 10.5 0.1 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FimP PF09766.4 CCF38998.1 - 7.8e-26 90.9 5.4 1.1e-25 90.5 3.8 1.1 1 0 0 1 1 1 1 Fms-interacting protein Phi-29_GP3 PF05435.6 CCF38998.1 - 0.02 14.1 0.0 0.03 13.5 0.0 1.3 1 0 0 1 1 1 0 Phi-29 DNA terminal protein GP3 HD_3 PF13023.1 CCF38998.1 - 0.024 14.3 0.2 0.024 14.3 0.2 1.6 2 0 0 2 2 2 0 HD domain K-box PF01486.12 CCF38998.1 - 0.051 13.3 0.6 0.051 13.3 0.4 3.0 2 2 2 4 4 4 0 K-box region Laminin_II PF06009.7 CCF38998.1 - 0.094 12.4 3.6 0.055 13.2 0.4 2.1 2 0 0 2 2 2 0 Laminin Domain II Pox_F11 PF04943.7 CCF38998.1 - 0.12 11.2 0.8 0.2 10.4 0.5 1.7 1 1 0 1 1 1 0 Poxvirus F11 protein DUF4200 PF13863.1 CCF38998.1 - 0.81 9.6 10.9 0.38 10.7 1.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) DUF3270 PF11674.3 CCF39000.1 - 0.39 10.7 5.7 0.29 11.1 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3270) Kelch_5 PF13854.1 CCF39002.1 - 4.1e-13 48.9 3.6 1.7e-12 46.9 0.7 3.2 3 0 0 3 3 3 1 Kelch motif SKG6 PF08693.5 CCF39002.1 - 0.0027 16.9 4.6 0.0027 16.9 3.2 2.1 2 0 0 2 2 2 1 Transmembrane alpha-helix domain Kelch_4 PF13418.1 CCF39002.1 - 0.0052 16.5 4.0 0.48 10.2 0.0 4.8 5 1 0 5 5 5 1 Galactose oxidase, central domain Kelch_1 PF01344.20 CCF39002.1 - 0.014 14.9 2.6 2.6 7.6 0.3 3.4 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.1 CCF39002.1 - 0.044 13.9 2.2 0.31 11.2 0.1 3.5 4 1 0 4 4 4 0 Kelch motif Glyco_hydro_3 PF00933.16 CCF39003.1 - 3.9e-70 236.2 0.0 4.4e-70 236.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fungal_trans PF04082.13 CCF39004.1 - 5.8e-15 54.8 0.9 6.2e-14 51.4 0.1 2.7 2 1 0 2 2 2 1 Fungal specific transcription factor domain 2OG-FeII_Oxy PF03171.15 CCF39006.1 - 0.0018 18.5 0.0 0.0038 17.4 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 CCF39006.1 - 0.0062 17.0 0.0 0.014 15.8 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF1235 PF06822.7 CCF39006.1 - 0.017 14.0 0.0 0.024 13.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1235) Peptidase_M35 PF02102.10 CCF39007.1 - 5.2e-11 41.7 0.1 5.5e-11 41.7 0.1 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family TFIIA PF03153.8 CCF39008.1 - 0.026 14.4 11.1 0.025 14.4 7.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.7 CCF39008.1 - 0.028 12.3 9.6 0.032 12.1 6.7 1.0 1 0 0 1 1 1 0 Nop14-like family DUF2146 PF10220.4 CCF39008.1 - 0.28 9.1 3.9 0.32 8.9 2.7 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) CENP-T PF15511.1 CCF39008.1 - 0.37 9.9 8.7 0.48 9.6 6.1 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T CDC45 PF02724.9 CCF39008.1 - 0.67 7.9 9.0 0.81 7.6 6.3 1.0 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.7 CCF39008.1 - 1.9 7.6 16.3 2.3 7.4 11.3 1.0 1 0 0 1 1 1 0 SDA1 Sigma70_ner PF04546.8 CCF39008.1 - 2 7.9 9.6 3.1 7.3 6.7 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region NOA36 PF06524.7 CCF39008.1 - 9.8 5.3 13.8 12 5.0 9.6 1.1 1 0 0 1 1 1 0 NOA36 protein Fungal_trans_2 PF11951.3 CCF39009.1 - 3.2e-19 68.8 0.0 3.7e-19 68.5 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain HET PF06985.6 CCF39012.1 - 2e-24 86.3 0.0 3.5e-24 85.5 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF3328 PF11807.3 CCF39013.1 - 2.8e-17 63.1 5.1 3.7e-17 62.7 3.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.3 CCF39014.1 - 1.3e-37 129.5 2.4 1.7e-37 129.2 1.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) MFS_1 PF07690.11 CCF39015.1 - 8.4e-23 80.6 27.1 1e-22 80.3 15.7 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF39015.1 - 1.6e-09 36.5 1.0 2.3e-09 36.0 0.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 CCF39015.1 - 0.00024 19.7 8.0 0.0066 15.0 2.0 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter HET PF06985.6 CCF39016.1 - 2.7e-18 66.4 0.0 7.2e-18 65.0 0.0 1.8 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) Zn_clus PF00172.13 CCF39017.1 - 4e-06 26.6 10.0 1e-05 25.3 6.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pox_F17 PF04767.7 CCF39017.1 - 3.3 8.0 7.1 1.6 9.0 2.8 2.0 1 1 1 2 2 2 0 DNA-binding 11 kDa phosphoprotein Sugar_tr PF00083.19 CCF39018.1 - 1.6e-114 382.9 22.3 1.8e-114 382.7 15.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF39018.1 - 4.6e-24 84.7 21.3 4.6e-24 84.7 14.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily COesterase PF00135.23 CCF39019.1 - 8.3e-93 311.8 0.0 1.1e-92 311.5 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF39019.1 - 0.00084 18.9 0.0 0.0022 17.5 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Pec_lyase_C PF00544.14 CCF39020.1 - 1.8e-32 112.4 3.0 2.5e-32 111.9 2.1 1.3 1 0 0 1 1 1 1 Pectate lyase Beta_helix PF13229.1 CCF39020.1 - 0.013 15.2 1.5 0.24 11.1 0.8 2.1 1 1 1 2 2 2 0 Right handed beta helix region VSP PF03302.8 CCF39021.1 - 0.00012 20.9 0.1 0.00017 20.3 0.0 1.2 1 0 0 1 1 1 1 Giardia variant-specific surface protein Podoplanin PF05808.6 CCF39021.1 - 0.00098 18.7 1.7 0.0018 17.8 0.0 2.2 3 0 0 3 3 3 1 Podoplanin Yip1 PF04893.12 CCF39021.1 - 0.022 14.2 0.2 0.033 13.6 0.2 1.2 1 0 0 1 1 1 0 Yip1 domain DUF1183 PF06682.7 CCF39021.1 - 0.043 13.4 2.4 0.6 9.6 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1183) DUF4448 PF14610.1 CCF39021.1 - 0.067 12.6 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) MtrF PF09472.5 CCF39021.1 - 0.65 9.2 3.4 1.3 8.3 2.3 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) DUF846 PF05832.7 CCF39022.1 - 1.9e-51 173.5 10.9 2.2e-51 173.2 7.6 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Tic20 PF09685.5 CCF39022.1 - 0.11 12.4 12.4 0.29 11.1 2.2 2.2 2 0 0 2 2 2 0 Tic20-like protein DUF4191 PF13829.1 CCF39022.1 - 1.1 8.2 11.2 2.9 6.9 0.7 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4191) Pex24p PF06398.6 CCF39022.1 - 1.6 7.4 10.8 2.3 6.8 0.7 2.1 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin Mago_nashi PF02792.9 CCF39024.1 - 3e-75 250.7 0.3 3.4e-75 250.5 0.2 1.0 1 0 0 1 1 1 1 Mago nashi protein Phage_portal_2 PF05136.8 CCF39024.1 - 0.035 12.6 0.0 0.043 12.3 0.0 1.0 1 0 0 1 1 1 0 Phage portal protein, lambda family RXT2_N PF08595.6 CCF39025.1 - 7.7e-30 103.6 0.3 3.2e-29 101.6 0.0 2.1 2 0 0 2 2 2 1 RXT2-like, N-terminal PEMT PF04191.8 CCF39026.1 - 5.1e-33 113.3 4.7 6.8e-33 112.9 2.4 1.7 2 0 0 2 2 2 1 Phospholipid methyltransferase Methyltransf_23 PF13489.1 CCF39028.1 - 5e-15 55.5 0.0 7e-15 55.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF39028.1 - 1.2e-08 35.4 0.0 3.5e-08 33.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF39028.1 - 3.8e-08 33.7 0.0 6.6e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF39028.1 - 1.8e-07 30.8 0.0 5.4e-07 29.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF39028.1 - 5.1e-07 30.0 0.0 2.5e-06 27.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF39028.1 - 3.3e-05 23.0 0.0 0.00026 20.1 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.13 CCF39028.1 - 0.00063 18.9 0.0 0.029 13.4 0.0 2.5 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family PrmA PF06325.8 CCF39028.1 - 0.00084 18.5 0.1 0.0018 17.4 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.1 CCF39028.1 - 0.0019 18.4 0.0 0.0041 17.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF39028.1 - 0.0037 16.6 0.0 0.0086 15.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain FtsJ PF01728.14 CCF39028.1 - 0.0039 17.1 0.0 0.0063 16.5 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_26 PF13659.1 CCF39028.1 - 0.016 15.2 0.0 0.022 14.7 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain CMAS PF02353.15 CCF39028.1 - 0.023 13.7 0.0 0.039 13.0 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase UPF0146 PF03686.8 CCF39028.1 - 0.044 13.5 0.0 0.084 12.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) Methyltransf_2 PF00891.13 CCF39028.1 - 0.045 12.9 0.0 0.071 12.2 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_16 PF10294.4 CCF39028.1 - 0.087 12.2 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase GidB PF02527.10 CCF39028.1 - 0.16 11.0 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G PBP PF01161.15 CCF39031.1 - 4.4e-26 91.4 0.1 5.5e-26 91.1 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein MdcE PF06833.6 CCF39031.1 - 0.098 11.8 0.1 0.15 11.2 0.1 1.2 1 0 0 1 1 1 0 Malonate decarboxylase gamma subunit (MdcE) SBDS_C PF09377.5 CCF39032.1 - 0.022 14.4 0.1 0.026 14.2 0.1 1.3 1 0 0 1 1 1 0 SBDS protein C-terminal domain ADH_zinc_N PF00107.21 CCF39033.1 - 7.5e-15 54.6 0.0 1.1e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF39033.1 - 2.2e-05 24.1 0.0 3.7e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 CCF39033.1 - 0.027 15.3 0.0 0.05 14.5 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.16 CCF39033.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain TraB PF01963.12 CCF39033.1 - 0.14 11.5 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 TraB family Sugar_tr PF00083.19 CCF39034.1 - 4.2e-40 137.6 6.7 4.7e-40 137.5 4.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Amidase PF01425.16 CCF39035.1 - 5.4e-69 233.1 0.1 2.4e-66 224.4 0.0 2.1 2 0 0 2 2 2 2 Amidase p450 PF00067.17 CCF39037.1 - 4.1e-29 101.4 0.0 1.9e-18 66.2 0.0 2.4 2 1 0 2 2 2 2 Cytochrome P450 Trp_DMAT PF11991.3 CCF39038.1 - 4.2e-85 286.1 0.0 5.1e-85 285.8 0.0 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase p450 PF00067.17 CCF39039.1 - 1e-14 53.9 0.0 1.5e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Kei1 PF08552.6 CCF39040.1 - 2.3e-52 177.3 1.8 2.9e-52 177.0 1.3 1.1 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 DUF2975 PF11188.3 CCF39040.1 - 0.00091 18.9 1.0 0.0027 17.4 0.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2975) SPC12 PF06645.8 CCF39040.1 - 6.2 6.7 5.9 0.9 9.3 1.1 1.9 2 1 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Ras PF00071.17 CCF39041.1 - 9.6e-60 200.6 0.5 1.3e-59 200.2 0.4 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF39041.1 - 1.4e-21 77.2 0.2 2.5e-21 76.3 0.0 1.5 2 0 0 2 2 1 1 Miro-like protein Arf PF00025.16 CCF39041.1 - 2.6e-18 65.8 0.3 3.2e-18 65.5 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 CCF39041.1 - 1.6e-08 34.2 0.1 7.1e-08 32.1 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 CCF39041.1 - 1.7e-06 27.3 0.4 2.1e-06 27.0 0.3 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 CCF39041.1 - 6.4e-06 25.4 0.1 1.2e-05 24.6 0.1 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 CCF39041.1 - 6.5e-06 26.0 0.0 1.1e-05 25.2 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.12 CCF39041.1 - 0.0077 15.7 0.2 0.026 14.0 0.0 1.7 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_28 PF13521.1 CCF39041.1 - 0.025 14.5 0.0 1.7 8.5 0.0 2.2 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.18 CCF39041.1 - 0.028 14.2 0.2 3 7.6 0.0 2.5 2 1 0 2 2 2 0 Dynamin family AAA_14 PF13173.1 CCF39041.1 - 0.071 13.0 0.3 0.14 12.0 0.2 1.6 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 CCF39041.1 - 0.082 12.6 0.2 4 7.1 0.0 2.3 2 1 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 CCF39041.1 - 0.1 12.7 0.0 1.8 8.7 0.0 2.4 1 1 1 2 2 2 0 AAA domain Nop53 PF07767.6 CCF39042.1 - 3.6e-57 194.1 2.6 4.3e-57 193.8 1.8 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) DUF3161 PF11362.3 CCF39042.1 - 0.044 13.6 0.1 0.079 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3161) His_Phos_1 PF00300.17 CCF39043.1 - 1.5e-16 60.8 0.0 2e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF2235 PF09994.4 CCF39044.1 - 5.1e-63 213.0 0.0 7.7e-63 212.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) DUF1870 PF08965.5 CCF39044.1 - 0.0056 16.3 0.4 3.9 7.1 0.0 2.8 3 0 0 3 3 3 2 Domain of unknown function (DUF1870) ROK PF00480.15 CCF39044.1 - 0.037 13.8 0.0 0.061 13.1 0.0 1.3 1 0 0 1 1 1 0 ROK family RE_TaqI PF09573.5 CCF39044.1 - 0.042 12.9 0.1 0.13 11.3 0.0 1.8 2 0 0 2 2 2 0 TaqI restriction endonuclease DUF155 PF02582.9 CCF39046.1 - 9.8e-57 191.6 0.6 1.4e-56 191.1 0.4 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 PHA-1 PF06542.6 CCF39046.1 - 0.11 11.2 0.1 0.61 8.7 0.0 1.9 2 0 0 2 2 2 0 Regulator protein PHA-1 HMG_box PF00505.14 CCF39047.1 - 9e-11 41.8 0.6 1.9e-10 40.8 0.2 1.7 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 CCF39047.1 - 1.4e-05 25.3 0.7 1.4e-05 25.3 0.5 2.4 3 0 0 3 3 3 1 HMG-box domain DUF972 PF06156.8 CCF39047.1 - 0.27 11.5 0.1 0.27 11.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF972) LRR_4 PF12799.2 CCF39048.1 - 6.1e-32 108.7 26.9 1.2e-07 31.1 3.2 7.8 4 2 1 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CCF39048.1 - 2e-26 91.5 27.0 6.9e-10 38.5 0.2 6.8 4 2 1 6 6 6 5 Leucine rich repeat LRR_1 PF00560.28 CCF39048.1 - 5.7e-12 43.9 25.9 0.27 11.4 0.5 12.9 12 2 1 13 13 13 3 Leucine Rich Repeat LRR_7 PF13504.1 CCF39048.1 - 2.9e-09 35.6 28.4 15 6.2 0.0 11.9 11 0 0 11 11 11 2 Leucine rich repeat LRR_6 PF13516.1 CCF39048.1 - 2.3e-08 33.2 22.0 1.3 9.3 0.0 10.6 10 2 2 12 12 12 2 Leucine Rich repeat LRR_9 PF14580.1 CCF39048.1 - 0.00016 21.2 11.6 0.73 9.3 0.9 4.3 2 1 3 5 5 5 5 Leucine-rich repeat Toxin_54 PF15533.1 CCF39048.1 - 0.11 12.7 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 Putative toxin 54 Phosphonate-bd PF12974.2 CCF39049.1 - 0.003 16.9 0.0 0.004 16.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1 PF09084.6 CCF39049.1 - 0.014 14.9 0.0 0.1 12.1 0.0 2.0 1 1 1 2 2 2 0 NMT1/THI5 like CTP_transf_2 PF01467.21 CCF39050.1 - 4.8e-08 33.2 0.0 5e-07 29.9 0.0 2.4 1 1 0 1 1 1 1 Cytidylyltransferase WLM PF08325.5 CCF39051.1 - 3.1e-49 167.3 0.0 5.3e-49 166.6 0.0 1.4 1 1 0 1 1 1 1 WLM domain zf-RanBP PF00641.13 CCF39051.1 - 8.3e-05 21.6 2.7 0.00017 20.6 1.9 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Peptidase_M54 PF07998.6 CCF39051.1 - 0.16 11.7 0.0 0.22 11.2 0.0 1.1 1 0 0 1 1 1 0 Peptidase family M54 DUF45 PF01863.12 CCF39051.1 - 0.3 10.8 1.1 0.42 10.3 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function DUF45 KR PF08659.5 CCF39052.1 - 3.5e-16 59.3 0.0 9.7e-16 57.9 0.0 1.8 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 CCF39052.1 - 6.7e-11 42.3 0.2 2.9e-10 40.3 0.0 2.1 2 1 0 2 2 2 1 short chain dehydrogenase Thymidylat_synt PF00303.14 CCF39053.1 - 2.8e-117 390.5 0.0 3.2e-117 390.3 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase HTH_Tnp_Tc5 PF03221.11 CCF39054.1 - 1.2e-17 63.4 1.9 7.7e-17 60.8 0.1 2.6 2 1 1 3 3 3 1 Tc5 transposase DNA-binding domain DUF4604 PF15377.1 CCF39054.1 - 0.011 15.9 0.2 0.021 15.0 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) MFS_1 PF07690.11 CCF39057.1 - 2.2e-34 118.7 26.4 2.2e-34 118.7 18.3 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily BT1 PF03092.11 CCF39057.1 - 0.016 13.9 4.6 0.079 11.6 0.3 2.2 2 0 0 2 2 2 0 BT1 family Ribonuc_L-PSP PF01042.16 CCF39058.1 - 2.2e-39 133.9 0.0 2.4e-39 133.8 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP TrwC PF08751.6 CCF39058.1 - 0.097 12.0 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 TrwC relaxase Pirin PF02678.11 CCF39058.1 - 0.12 12.3 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Pirin Abhydrolase_3 PF07859.8 CCF39059.1 - 2.2e-53 180.9 0.3 4.7e-53 179.8 0.2 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF39059.1 - 8.5e-07 28.4 0.0 1.4e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.23 CCF39059.1 - 0.0044 15.7 0.2 0.066 11.9 0.0 2.0 2 0 0 2 2 2 1 Carboxylesterase family Abhydrolase_5 PF12695.2 CCF39059.1 - 0.022 14.4 0.0 0.033 13.9 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family p450 PF00067.17 CCF39060.1 - 7.5e-63 212.6 0.0 8.5e-63 212.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 WD40 PF00400.27 CCF39063.1 - 5.1e-28 95.9 5.1 1.4e-07 31.0 0.0 5.9 6 0 0 6 6 6 5 WD domain, G-beta repeat BBS2_Mid PF14783.1 CCF39063.1 - 0.021 14.6 0.1 20 5.0 0.0 3.4 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region LEA_4 PF02987.11 CCF39067.1 - 0.0025 17.6 4.3 0.0025 17.6 3.0 3.2 2 1 0 3 3 3 2 Late embryogenesis abundant protein AAA_27 PF13514.1 CCF39067.1 - 0.022 12.5 11.9 0.025 12.3 8.2 1.0 1 0 0 1 1 1 0 AAA domain DUF3810 PF12725.2 CCF39067.1 - 0.92 8.3 4.5 1.1 8.0 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Herpes_UL17 PF04559.7 CCF39067.1 - 2.8 6.4 7.5 3 6.3 5.2 1.0 1 0 0 1 1 1 0 Herpesvirus UL17 protein Dynactin_p62 PF05502.8 CCF39067.1 - 3.4 6.3 11.1 3.5 6.2 7.7 1.0 1 0 0 1 1 1 0 Dynactin p62 family DUF3584 PF12128.3 CCF39067.1 - 5 4.3 17.6 5.8 4.1 12.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4407 PF14362.1 CCF39067.1 - 5.9 5.7 14.5 7 5.5 10.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPP_enzyme_N PF02776.13 CCF39068.1 - 2.6e-36 124.7 1.7 4.2e-36 124.0 0.6 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 CCF39068.1 - 3.2e-18 65.7 0.0 7.9e-17 61.2 0.0 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 CCF39068.1 - 1.3e-16 60.6 0.0 2.9e-16 59.4 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain zf-RING_2 PF13639.1 CCF39071.1 - 1.3e-13 50.5 5.6 2.1e-13 49.8 3.9 1.3 1 0 0 1 1 1 1 Ring finger domain PA PF02225.17 CCF39071.1 - 7.5e-13 48.0 0.0 1.9e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 PA domain zf-C3HC4_2 PF13923.1 CCF39071.1 - 2e-09 37.3 5.2 3.3e-09 36.6 3.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 CCF39071.1 - 4.5e-09 36.2 1.6 8.5e-09 35.3 1.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 CCF39071.1 - 1.1e-08 34.6 3.1 1.7e-08 33.9 2.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF39071.1 - 5.9e-08 32.2 3.2 9e-08 31.6 2.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF39071.1 - 2.7e-07 30.1 2.4 4.3e-07 29.5 1.7 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-Apc11 PF12861.2 CCF39071.1 - 0.001 18.8 0.7 0.0018 18.0 0.5 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.1 CCF39071.1 - 0.054 13.3 3.8 0.21 11.4 2.8 1.9 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.3 CCF39071.1 - 0.087 12.8 2.4 0.21 11.5 1.6 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.2 CCF39071.1 - 0.098 12.7 3.7 0.18 11.8 2.6 1.5 1 0 0 1 1 1 0 RING-variant domain zf-RING_UBOX PF13445.1 CCF39071.1 - 0.1 12.3 2.6 0.24 11.1 1.8 1.7 1 0 0 1 1 1 0 RING-type zinc-finger Baculo_RING PF05883.6 CCF39071.1 - 0.24 11.2 0.1 0.41 10.4 0.1 1.3 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain zf-RING_4 PF14570.1 CCF39071.1 - 0.95 9.1 2.5 1.8 8.2 1.8 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.6 CCF39071.1 - 1.7 8.6 3.4 3.1 7.8 2.4 1.4 1 0 0 1 1 1 0 RING-like domain MFS_1 PF07690.11 CCF39072.1 - 9.8e-40 136.3 26.0 1.6e-39 135.6 18.0 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily HupE_UreJ PF04955.7 CCF39072.1 - 0.00098 18.4 4.9 0.00098 18.4 3.4 2.5 2 2 1 3 3 3 1 HupE / UreJ protein Fungal_trans PF04082.13 CCF39073.1 - 4.5e-17 61.7 0.0 7e-17 61.1 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF39073.1 - 6e-08 32.4 8.4 6e-08 32.4 5.8 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF39074.1 - 1.2e-16 60.3 1.4 2.1e-16 59.5 0.9 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.1 CCF39074.1 - 2.4e-08 33.8 12.2 1.7e-05 24.8 4.1 3.0 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 CCF39074.1 - 4.9e-05 23.3 13.0 0.0041 17.3 3.6 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF39074.1 - 0.00023 21.2 14.7 0.035 14.4 4.0 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type RhgB_N PF09284.5 CCF39075.1 - 5.8e-61 205.9 1.8 5.8e-61 205.9 1.2 1.6 2 0 0 2 2 2 1 Rhamnogalacturonase B, N-terminal CBM-like PF14683.1 CCF39075.1 - 5.1e-46 156.3 0.1 5.1e-46 156.3 0.1 2.0 3 0 0 3 3 3 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.1 CCF39075.1 - 1.2e-15 57.3 1.4 4.4e-15 55.5 1.0 2.0 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.1 CCF39075.1 - 0.0013 18.6 2.0 0.0016 18.4 0.2 2.0 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain RicinB_lectin_2 PF14200.1 CCF39075.1 - 0.049 14.0 0.2 0.9 9.9 0.0 2.5 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like An_peroxidase PF03098.10 CCF39076.1 - 1.1e-98 330.9 0.0 7.8e-96 321.5 0.0 2.1 1 1 0 1 1 1 1 Animal haem peroxidase p450 PF00067.17 CCF39076.1 - 0.00083 17.9 0.1 0.068 11.6 0.0 2.7 2 1 0 2 2 2 1 Cytochrome P450 NOC3p PF07540.6 CCF39078.1 - 5.3e-32 109.9 3.2 1.5e-31 108.5 0.2 3.0 3 0 0 3 3 3 1 Nucleolar complex-associated protein CBF PF03914.12 CCF39078.1 - 1.3e-26 93.0 0.6 5.2e-26 91.0 0.2 2.1 2 0 0 2 2 2 1 CBF/Mak21 family RRN3 PF05327.6 CCF39078.1 - 0.026 12.6 0.1 0.026 12.6 0.1 2.7 3 1 1 4 4 4 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2360 PF10152.4 CCF39078.1 - 0.24 11.6 0.0 0.24 11.6 0.0 2.7 2 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) UPF0113 PF03657.8 CCF39079.1 - 7.2e-08 32.2 0.0 1e-07 31.7 0.0 1.4 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0113) Nol1_Nop2_Fmu_2 PF13636.1 CCF39079.1 - 0.043 13.8 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 pre-rRNA processing and ribosome biogenesis PUA PF01472.15 CCF39079.1 - 0.086 12.5 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 PUA domain AA_kinase PF00696.23 CCF39080.1 - 2.5e-39 135.2 1.2 4.1e-39 134.5 0.8 1.2 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.15 CCF39080.1 - 9.1e-14 50.9 0.2 8.7e-13 47.7 0.0 2.5 2 0 0 2 2 2 1 PUA domain Peptidase_M76 PF09768.4 CCF39081.1 - 8.1e-67 224.0 1.6 1e-66 223.6 1.1 1.1 1 0 0 1 1 1 1 Peptidase M76 family SprT-like PF10263.4 CCF39081.1 - 0.016 14.8 0.7 0.016 14.8 0.5 2.2 1 1 1 3 3 3 0 SprT-like family Pkinase PF00069.20 CCF39082.1 - 2e-58 197.6 0.0 1.4e-56 191.5 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF39082.1 - 9.1e-34 116.6 0.0 1.5e-31 109.4 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF39082.1 - 3.2e-06 26.3 0.0 6.3e-06 25.3 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 CCF39082.1 - 0.00026 20.1 0.0 0.00043 19.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 CCF39082.1 - 0.018 14.4 0.1 0.068 12.4 0.0 1.9 1 1 1 2 2 2 0 PhoP regulatory network protein YrbL APH PF01636.18 CCF39082.1 - 0.067 12.9 0.0 0.11 12.1 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_S8 PF00082.17 CCF39083.1 - 1.2e-10 40.9 0.1 1.8e-10 40.4 0.1 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 CCF39083.1 - 0.12 12.9 0.0 0.21 12.1 0.0 1.4 1 0 0 1 1 1 0 Peptidase inhibitor I9 BRX PF08381.6 CCF39085.1 - 0.16 11.0 0.4 0.29 10.2 0.3 1.4 1 0 0 1 1 1 0 Transcription factor regulating root and shoot growth via Pin3 Glyco_hydro_3 PF00933.16 CCF39086.1 - 3.8e-51 173.8 0.1 5.5e-51 173.3 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 CCF39086.1 - 4e-48 163.8 0.0 9.3e-48 162.7 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 CCF39086.1 - 2.2e-24 85.1 0.1 4e-24 84.3 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Nodulin-like PF06813.8 CCF39088.1 - 9.4e-06 25.0 3.0 0.0061 15.8 0.0 3.2 3 1 1 4 4 4 2 Nodulin-like HpaP PF09483.5 CCF39088.1 - 0.045 13.7 0.5 0.067 13.1 0.4 1.2 1 0 0 1 1 1 0 Type III secretion protein (HpaP) ECH PF00378.15 CCF39091.1 - 3.6e-26 91.7 0.0 3.9e-26 91.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Vps51 PF08700.6 CCF39092.1 - 1.6e-14 53.4 0.0 6.2e-14 51.6 0.0 2.0 1 0 0 1 1 1 1 Vps51/Vps67 DUF4525 PF15027.1 CCF39092.1 - 0.06 12.8 0.1 0.14 11.6 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) RR_TM4-6 PF06459.7 CCF39092.1 - 0.6 9.9 10.0 1.1 9.0 7.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CobT PF06213.7 CCF39092.1 - 7.2 5.6 18.6 0.33 10.0 8.9 1.7 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Aldedh PF00171.17 CCF39093.1 - 6.6e-84 281.8 0.2 7.7e-84 281.6 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Rhodanese PF00581.15 CCF39095.1 - 1.1e-13 51.5 0.0 2.4e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_31 PF13847.1 CCF39096.1 - 2.6e-30 105.0 0.0 3.7e-30 104.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF39096.1 - 2.9e-20 72.5 0.0 5.5e-20 71.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF39096.1 - 2.6e-16 59.4 0.0 4.3e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 CCF39096.1 - 1.2e-14 54.5 0.3 3.1e-14 53.1 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF39096.1 - 1e-13 51.8 0.0 1.7e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF39096.1 - 9.3e-12 44.9 0.0 1.5e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF39096.1 - 1.8e-11 44.1 0.0 3.6e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF39096.1 - 4.6e-10 39.8 0.0 7.8e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 CCF39096.1 - 6.3e-08 32.0 0.0 9.2e-08 31.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 CCF39096.1 - 3.8e-07 29.6 0.0 6.5e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 CCF39096.1 - 8.6e-07 28.6 0.0 2e-06 27.5 0.0 1.6 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0020 PF01170.13 CCF39096.1 - 3.4e-05 23.4 0.0 5.1e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_4 PF02390.12 CCF39096.1 - 6.1e-05 22.1 0.1 0.00016 20.8 0.1 1.6 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_32 PF13679.1 CCF39096.1 - 0.00041 20.0 0.0 0.00073 19.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 CCF39096.1 - 0.00098 18.8 0.0 0.0017 18.0 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_3 PF01596.12 CCF39096.1 - 0.0025 16.8 0.0 0.0041 16.2 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase CMAS PF02353.15 CCF39096.1 - 0.0083 15.2 0.0 0.012 14.6 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase DOT1 PF08123.8 CCF39096.1 - 0.01 15.1 0.1 0.016 14.5 0.0 1.4 1 1 0 1 1 1 0 Histone methylation protein DOT1 FtsJ PF01728.14 CCF39096.1 - 0.02 14.9 0.0 0.029 14.3 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_15 PF09445.5 CCF39096.1 - 0.087 12.3 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Sugar_tr PF00083.19 CCF39097.1 - 6.1e-84 282.1 24.8 7.1e-84 281.9 17.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF39097.1 - 4.4e-21 74.9 41.1 3.8e-16 58.7 20.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.15 CCF39097.1 - 0.0064 14.6 0.5 0.024 12.6 0.2 1.9 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Fijivirus_P9-2 PF06837.6 CCF39097.1 - 0.027 13.6 0.2 0.045 12.8 0.2 1.3 1 0 0 1 1 1 0 Fijivirus P9-2 protein Acetyltransf_1 PF00583.19 CCF39098.1 - 5.6e-14 51.9 0.0 8.1e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF39098.1 - 1.6e-08 34.5 0.0 2.3e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CCF39098.1 - 4.5e-07 30.0 0.0 5.7e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 CCF39098.1 - 0.00013 22.1 0.0 0.00016 21.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF39098.1 - 0.00087 19.0 0.0 0.002 17.8 0.0 1.6 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_4 PF13420.1 CCF39098.1 - 0.0042 17.0 0.0 0.0052 16.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 CCF39098.1 - 0.098 12.5 0.0 0.16 11.8 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 CCF39098.1 - 0.13 12.0 0.0 0.25 11.2 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain RicinB_lectin_2 PF14200.1 CCF39099.1 - 1.5e-05 25.2 0.0 0.00018 21.7 0.0 2.1 1 1 1 2 2 2 1 Ricin-type beta-trefoil lectin domain-like DUF4482 PF14818.1 CCF39100.1 - 0.026 15.2 4.5 0.044 14.4 3.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) CK2S PF15011.1 CCF39101.1 - 0.041 13.6 0.0 0.57 9.9 0.0 2.2 2 0 0 2 2 2 0 Casein Kinase 2 substrate Ank_2 PF12796.2 CCF39102.1 - 1.1e-108 355.7 13.2 3e-17 62.7 0.7 7.4 3 2 4 7 7 7 7 Ankyrin repeats (3 copies) Ank PF00023.25 CCF39102.1 - 3.5e-102 329.4 19.3 1.5e-07 30.8 0.2 15.9 16 0 0 16 16 16 15 Ankyrin repeat Ank_4 PF13637.1 CCF39102.1 - 2.4e-85 279.5 14.6 6.7e-12 45.5 0.0 11.5 7 4 4 11 11 11 11 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF39102.1 - 4.5e-78 249.3 10.6 4.9e-05 23.1 0.0 16.2 16 0 0 16 16 16 15 Ankyrin repeat Ank_5 PF13857.1 CCF39102.1 - 1.1e-75 247.8 24.6 4.3e-10 39.4 0.5 13.2 3 2 11 14 14 14 13 Ankyrin repeats (many copies) Shigella_OspC PF06128.6 CCF39102.1 - 0.059 12.8 0.5 13 5.2 0.0 4.4 5 1 0 5 5 5 0 Shigella flexneri OspC protein GSDH PF07995.6 CCF39105.1 - 0.023 13.8 0.1 0.038 13.0 0.1 1.5 1 1 0 1 1 1 0 Glucose / Sorbosone dehydrogenase PD40 PF07676.7 CCF39105.1 - 0.029 14.0 0.0 0.063 12.9 0.0 1.5 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat SGL PF08450.7 CCF39105.1 - 0.038 13.3 0.0 0.068 12.5 0.0 1.4 1 0 0 1 1 1 0 SMP-30/Gluconolaconase/LRE-like region WD40 PF00400.27 CCF39106.1 - 1.5e-49 164.2 20.9 5.5e-12 45.0 0.0 6.4 6 1 0 6 6 6 6 WD domain, G-beta repeat TFIIIC_delta PF12657.2 CCF39106.1 - 6.2e-09 35.8 12.6 0.0035 17.0 0.1 4.3 2 2 3 5 5 5 3 Transcription factor IIIC subunit delta N-term IKI3 PF04762.7 CCF39106.1 - 0.06 11.1 2.8 1 7.0 0.0 2.2 2 0 0 2 2 2 0 IKI3 family DUF1034 PF06280.7 CCF39107.1 - 2e-15 57.1 0.0 4e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 Fn3-like domain (DUF1034) Peptidase_S8 PF00082.17 CCF39107.1 - 2.2e-12 46.7 0.6 4e-12 45.8 0.0 1.7 2 0 0 2 2 2 1 Subtilase family FlgD_ig PF13860.1 CCF39107.1 - 1.9e-06 27.5 0.0 4.7e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 FlgD Ig-like domain EFG_IV PF03764.13 CCF39108.1 - 8.8e-27 93.0 0.0 3.2e-26 91.2 0.0 1.9 2 1 1 3 3 3 1 Elongation factor G, domain IV EFG_C PF00679.19 CCF39108.1 - 2.3e-18 65.8 0.0 3.8e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G C-terminus DNA_pol_phi PF04931.8 CCF39109.1 - 1.1e-37 129.3 39.7 3.2e-35 121.1 23.5 3.2 3 1 0 3 3 3 2 DNA polymerase phi DUF29 PF01724.11 CCF39109.1 - 0.013 15.3 0.7 2.1 8.1 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function DUF29 Mg_trans_NIPA PF05653.9 CCF39114.1 - 4.2e-91 305.0 23.2 6.1e-91 304.5 16.1 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EmrE PF13536.1 CCF39114.1 - 1e-07 32.1 4.9 1e-07 32.1 3.4 3.4 2 1 1 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 CCF39114.1 - 5.8e-06 26.3 7.7 5.8e-06 26.3 5.4 3.0 3 1 0 3 3 3 1 EamA-like transporter family LANC_like PF05147.8 CCF39114.1 - 0.0092 14.5 0.0 0.014 13.9 0.0 1.2 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein DUF914 PF06027.7 CCF39114.1 - 2 7.2 16.0 7.3 5.3 10.6 2.1 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF914) Pkinase PF00069.20 CCF39117.1 - 8.7e-34 116.8 0.0 1.1e-33 116.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF39117.1 - 2.4e-11 43.2 0.0 6.7e-10 38.4 0.0 2.6 2 1 0 2 2 2 1 Protein tyrosine kinase RIO1 PF01163.17 CCF39117.1 - 0.18 11.1 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 RIO1 family DUF3592 PF12158.3 CCF39118.1 - 0.05 13.3 0.1 0.05 13.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3592) Gram_pos_anchor PF00746.16 CCF39119.1 - 1.6 8.5 4.8 2.5 7.9 3.3 1.3 1 0 0 1 1 1 0 Gram positive anchor Mgm101p PF06420.7 CCF39120.1 - 1.3e-89 297.9 0.0 1.7e-89 297.6 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 TB2_DP1_HVA22 PF03134.14 CCF39121.1 - 7.5e-31 105.7 8.5 1.1e-30 105.2 5.9 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family ABC2_membrane_3 PF12698.2 CCF39121.1 - 0.35 9.8 2.5 0.48 9.4 1.8 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein AA_permease_2 PF13520.1 CCF39122.1 - 9.6e-61 205.5 49.8 1.2e-60 205.2 34.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF39122.1 - 8.7e-31 106.7 38.6 1.2e-30 106.3 26.8 1.1 1 0 0 1 1 1 1 Amino acid permease GMC_oxred_N PF00732.14 CCF39123.1 - 1.2e-56 192.0 0.1 2e-56 191.3 0.1 1.3 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF39123.1 - 2.9e-33 115.2 0.4 5e-33 114.4 0.3 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 CCF39123.1 - 1.5e-06 27.3 0.2 2.4e-05 23.4 0.2 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF39123.1 - 4.3e-05 23.4 0.1 0.034 14.0 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF39123.1 - 0.00016 21.6 0.0 0.00055 19.9 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CCF39123.1 - 0.00062 18.7 0.4 0.019 13.8 0.0 2.4 2 1 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.1 CCF39123.1 - 0.0013 18.8 0.0 0.27 11.2 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF39123.1 - 0.011 14.7 0.0 0.019 14.0 0.0 1.2 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.9 CCF39123.1 - 0.015 13.7 0.0 0.079 11.4 0.0 1.9 2 0 0 2 2 2 0 HI0933-like protein Lycopene_cycl PF05834.7 CCF39123.1 - 0.051 12.5 0.0 0.085 11.7 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.1 CCF39123.1 - 0.051 13.3 0.1 0.12 12.1 0.0 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding COesterase PF00135.23 CCF39124.1 - 1e-96 324.7 0.0 1.4e-96 324.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF39124.1 - 0.00084 18.9 0.1 0.0018 17.8 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF3302 PF11742.3 CCF39125.1 - 0.6 9.9 5.9 0.99 9.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3302) DUF1415 PF07209.7 CCF39126.1 - 0.052 13.2 0.0 2.2 7.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1415) PQ-loop PF04193.9 CCF39127.1 - 3.8e-21 74.3 18.0 4.9e-12 45.2 0.5 3.3 3 1 1 4 4 4 2 PQ loop repeat DUF3796 PF12676.2 CCF39127.1 - 0.28 11.4 2.5 0.21 11.8 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3796) R3H PF01424.17 CCF39128.1 - 3.2e-05 23.5 0.0 4.6e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 R3H domain Amidase PF01425.16 CCF39129.1 - 6.2e-72 242.8 0.0 9.3e-72 242.2 0.0 1.2 1 0 0 1 1 1 1 Amidase NAD_binding_4 PF07993.7 CCF39131.1 - 4.8e-32 110.8 0.0 7.1e-32 110.2 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein adh_short PF00106.20 CCF39131.1 - 0.0017 18.3 0.0 0.0033 17.3 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase Peptidase_M36 PF02128.10 CCF39132.1 - 1.4e-49 168.8 0.0 1.6e-49 168.7 0.0 1.0 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) DUF3602 PF12223.3 CCF39135.1 - 1.7e-17 63.5 11.3 1.1e-13 51.3 2.5 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3602) Ank_2 PF12796.2 CCF39136.1 - 3.3e-89 293.3 5.0 4.9e-19 68.4 0.3 6.5 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 CCF39136.1 - 3.6e-73 237.9 10.5 1.9e-09 36.8 0.1 12.6 13 0 0 13 13 13 11 Ankyrin repeat Ank_4 PF13637.1 CCF39136.1 - 2.4e-58 193.5 6.2 8.5e-10 38.8 0.1 9.4 4 2 6 10 10 10 10 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF39136.1 - 3.7e-54 179.5 11.8 6.2e-09 35.8 0.0 9.8 4 3 7 11 11 11 9 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF39136.1 - 1.1e-52 170.7 1.3 6.8e-07 28.9 0.1 11.9 12 0 0 12 12 12 10 Ankyrin repeat MOZART1 PF12554.3 CCF39136.1 - 0.014 14.8 0.0 6.6 6.2 0.0 4.1 4 0 0 4 4 4 0 Mitotic-spindle organizing gamma-tubulin ring associated Pectate_lyase_3 PF12708.2 CCF39137.1 - 8.6e-74 248.4 9.4 6.5e-62 209.5 2.1 2.4 2 0 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.3 CCF39137.1 - 5.7e-07 28.9 0.8 0.0055 16.1 0.1 2.7 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase Beta_helix PF13229.1 CCF39137.1 - 0.0059 16.3 2.4 0.014 15.1 1.5 1.8 1 1 0 1 1 1 1 Right handed beta helix region Fork_head PF00250.13 CCF39138.1 - 7.9e-35 118.7 0.2 1.6e-34 117.8 0.1 1.4 1 0 0 1 1 1 1 Fork head domain NAS PF03059.11 CCF39139.1 - 4.2e-41 140.9 0.0 6.8e-41 140.2 0.0 1.2 1 0 0 1 1 1 1 Nicotianamine synthase protein Methyltransf_31 PF13847.1 CCF39139.1 - 9.4e-08 31.7 0.0 2.4e-07 30.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF39139.1 - 0.00017 22.1 0.1 0.00073 20.0 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF39139.1 - 0.0062 16.8 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Fungal_trans PF04082.13 CCF39140.1 - 1.6e-22 79.6 0.1 2.7e-22 78.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain CoA_transf_3 PF02515.12 CCF39141.1 - 4.2e-35 120.7 0.0 1.8e-30 105.6 0.0 2.7 2 1 1 3 3 3 2 CoA-transferase family III SANTA PF09133.5 CCF39141.1 - 0.036 14.0 0.0 0.085 12.8 0.0 1.6 1 1 0 1 1 1 0 SANTA (SANT Associated) eRF1_1 PF03463.10 CCF39141.1 - 0.16 11.5 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 eRF1 domain 1 p450 PF00067.17 CCF39142.1 - 3.1e-11 42.4 0.0 3.1e-11 42.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF2264 PF10022.4 CCF39143.1 - 4.1e-112 374.4 0.0 4.7e-112 374.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) MFS_1 PF07690.11 CCF39144.1 - 1.5e-22 79.8 24.5 1.5e-22 79.8 17.0 1.9 1 1 0 2 2 2 1 Major Facilitator Superfamily YajC PF02699.10 CCF39144.1 - 0.011 15.4 1.8 0.014 15.0 0.0 2.0 2 0 0 2 2 2 0 Preprotein translocase subunit PI3_PI4_kinase PF00454.22 CCF39145.1 - 2.5e-39 135.1 0.0 3.3e-39 134.7 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase RXT2_N PF08595.6 CCF39146.1 - 0.092 12.5 2.5 0.16 11.7 1.7 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal Spc7_N PF15402.1 CCF39146.1 - 0.25 9.3 7.9 0.28 9.1 5.4 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Nucleoplasmin PF03066.10 CCF39146.1 - 0.3 10.6 4.4 0.36 10.3 3.0 1.2 1 0 0 1 1 1 0 Nucleoplasmin NOA36 PF06524.7 CCF39146.1 - 2.1 7.5 6.6 2.4 7.3 4.6 1.1 1 0 0 1 1 1 0 NOA36 protein Ndc1_Nup PF09531.5 CCF39148.1 - 1.3e-93 314.5 0.0 1.4e-93 314.3 0.0 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup ABC2_membrane_5 PF13346.1 CCF39149.1 - 0.041 13.1 6.6 0.059 12.6 4.6 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein NICE-3 PF07406.6 CCF39149.1 - 0.054 12.9 0.0 3.4 7.1 0.0 2.2 2 0 0 2 2 2 0 NICE-3 protein DUF3827 PF12877.2 CCF39149.1 - 0.46 8.5 2.9 0.13 10.2 0.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3827) Fungal_trans PF04082.13 CCF39151.1 - 3.7e-08 32.5 0.1 1.2e-07 30.9 0.1 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF39151.1 - 1.6e-06 27.9 7.2 2.7e-06 27.1 5.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4503 PF14951.1 CCF39151.1 - 0.069 11.2 1.3 0.1 10.6 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) Asn_synthase PF00733.16 CCF39152.1 - 3e-52 177.6 0.0 4.2e-52 177.1 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 CCF39152.1 - 1.8e-36 124.6 0.0 2.8e-36 124.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 CCF39152.1 - 7.9e-34 116.4 0.0 1.4e-33 115.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.3 CCF39152.1 - 7.7e-07 28.5 0.0 1.3e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein GATase_2 PF00310.16 CCF39152.1 - 0.0046 15.7 0.1 1.1 7.8 0.0 3.4 2 1 2 4 4 4 1 Glutamine amidotransferases class-II NAD_synthase PF02540.12 CCF39152.1 - 0.038 12.8 0.0 0.061 12.2 0.0 1.2 1 0 0 1 1 1 0 NAD synthase 3Beta_HSD PF01073.14 CCF39153.1 - 6.2e-28 97.3 0.0 9.1e-27 93.4 0.0 2.1 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 CCF39153.1 - 2.8e-11 43.3 0.0 4.2e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.20 CCF39153.1 - 1.3e-09 38.2 0.0 2.2e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.1 CCF39153.1 - 4e-08 33.4 0.1 2.3e-07 31.0 0.1 2.2 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 CCF39153.1 - 4.7e-08 32.2 0.2 1.1e-07 31.1 0.0 1.6 2 0 0 2 2 2 1 Male sterility protein KR PF08659.5 CCF39153.1 - 0.00012 21.7 0.0 0.00026 20.7 0.0 1.5 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 CCF39153.1 - 0.00029 19.8 0.0 0.00042 19.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.12 CCF39153.1 - 0.087 11.6 0.1 0.2 10.4 0.0 1.6 2 0 0 2 2 2 0 RmlD substrate binding domain Acyl_transf_1 PF00698.16 CCF39154.1 - 1.7e-58 198.4 0.0 2.5e-58 197.9 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.1 CCF39154.1 - 1.9e-56 191.4 0.0 2.8e-56 190.8 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.17 CCF39154.1 - 1.9e-24 85.8 0.0 4.4e-24 84.6 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.7 CCF39154.1 - 7.9e-19 67.9 0.0 5.8e-18 65.2 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF39154.1 - 9.3e-12 44.7 0.0 2.2e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF39154.1 - 1.5e-10 40.9 0.0 3.8e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF39154.1 - 9.4e-10 38.8 0.0 2.8e-09 37.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF39154.1 - 2.1e-08 34.7 0.0 4.5e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF39154.1 - 0.00065 18.8 0.0 0.0012 18.0 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 CCF39154.1 - 0.0019 18.2 0.0 0.0043 17.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 CCF39154.1 - 0.038 13.0 0.0 0.063 12.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_16 PF10294.4 CCF39154.1 - 0.049 13.0 0.0 0.15 11.4 0.0 1.8 1 1 0 1 1 1 0 Putative methyltransferase Methyltransf_28 PF02636.12 CCF39154.1 - 0.22 10.8 0.0 0.83 8.9 0.0 1.9 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF915 PF06028.6 CCF39154.1 - 0.53 9.3 0.0 1.8 7.6 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) NUDIX PF00293.23 CCF39155.1 - 8.1e-08 31.9 0.7 1.4e-07 31.2 0.5 1.6 1 1 0 1 1 1 1 NUDIX domain ER_lumen_recept PF00810.13 CCF39156.1 - 1.2e-33 116.6 5.8 1.2e-33 116.6 4.0 1.5 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.9 CCF39156.1 - 0.07 12.6 0.0 0.07 12.6 0.0 2.9 4 1 0 4 4 4 0 PQ loop repeat ADK PF00406.17 CCF39158.1 - 1.6e-36 125.4 0.0 5.1e-21 75.1 0.0 2.1 2 0 0 2 2 2 2 Adenylate kinase ADK_lid PF05191.9 CCF39158.1 - 3.3e-13 49.0 0.0 8.2e-13 47.7 0.0 1.7 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_18 PF13238.1 CCF39158.1 - 7.4e-05 23.0 0.0 0.00034 20.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CCF39158.1 - 0.00051 20.8 0.0 0.0027 18.4 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.9 CCF39158.1 - 0.026 14.2 0.0 0.056 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 CCF39158.1 - 0.027 14.3 0.0 0.11 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain Guanylate_kin PF00625.16 CCF39158.1 - 0.12 11.8 0.0 0.23 10.8 0.0 1.5 1 0 0 1 1 1 0 Guanylate kinase LETM1 PF07766.8 CCF39159.1 - 5.8e-108 359.9 1.1 9e-108 359.3 0.8 1.3 1 0 0 1 1 1 1 LETM1-like protein SAP PF02037.22 CCF39159.1 - 2.9e-05 23.4 0.0 0.024 14.1 0.0 3.2 3 0 0 3 3 3 2 SAP domain RAP1 PF07218.6 CCF39159.1 - 0.33 8.9 6.2 0.54 8.2 4.3 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RTA1 PF04479.8 CCF39160.1 - 8.2e-39 133.4 10.4 2.2e-21 76.4 2.1 2.2 1 1 1 2 2 2 2 RTA1 like protein DUF4131 PF13567.1 CCF39160.1 - 3.8 6.8 12.9 0.24 10.8 2.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Cupin_3 PF05899.7 CCF39161.1 - 1.9e-06 27.1 0.0 3.1e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF861) EutQ PF06249.7 CCF39161.1 - 0.001 18.6 0.0 0.0011 18.5 0.0 1.1 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_2 PF07883.6 CCF39161.1 - 0.023 14.1 0.1 0.045 13.2 0.0 1.5 1 0 0 1 1 1 0 Cupin domain MFS_1 PF07690.11 CCF39163.1 - 8.7e-35 120.0 50.1 1.1e-33 116.3 34.6 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF39163.1 - 2.4e-09 36.3 27.8 2.2e-08 33.0 10.8 3.0 3 1 0 3 3 3 2 Sugar (and other) transporter adh_short PF00106.20 CCF39164.1 - 5.3e-18 65.4 0.1 8.1e-18 64.8 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF39164.1 - 2.8e-08 33.6 0.1 4.5e-08 32.9 0.1 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF39164.1 - 5.2e-07 29.6 0.0 8.7e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 CCF39164.1 - 4.3e-06 26.3 0.1 5.7e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF39164.1 - 0.0045 17.0 0.2 0.012 15.6 0.2 1.7 1 1 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF39164.1 - 0.027 13.7 0.2 0.044 13.0 0.1 1.3 1 0 0 1 1 1 0 NmrA-like family ACT_7 PF13840.1 CCF39164.1 - 0.094 12.2 0.1 15 5.1 0.0 2.4 2 0 0 2 2 2 0 ACT domain TIR PF01582.15 CCF39164.1 - 0.1 12.0 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 TIR domain adh_short PF00106.20 CCF39166.1 - 2.4e-20 73.1 0.0 8.2e-20 71.3 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 CCF39166.1 - 2.2e-10 40.4 0.0 3.5e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF39166.1 - 6.5e-09 35.9 0.0 1.3e-08 34.9 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 CCF39166.1 - 0.0089 16.0 0.1 0.035 14.0 0.1 2.0 1 1 0 1 1 1 1 NADH(P)-binding TIR PF01582.15 CCF39166.1 - 0.079 12.3 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 TIR domain Epimerase PF01370.16 CCF39166.1 - 0.12 11.8 0.1 0.16 11.3 0.0 1.3 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family EthD PF07110.6 CCF39167.1 - 2.6e-11 44.2 0.1 3.2e-11 44.0 0.1 1.1 1 0 0 1 1 1 1 EthD domain MFS_1 PF07690.11 CCF39169.1 - 1.4e-41 142.3 31.6 1.4e-41 142.3 21.9 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF39169.1 - 5.8e-13 48.2 22.1 1.8e-12 46.6 15.3 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter DUF1129 PF06570.6 CCF39169.1 - 1.5 8.0 8.6 0.12 11.7 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1129) Fasciclin PF02469.17 CCF39170.1 - 5.7e-29 100.7 0.0 4e-18 65.6 0.0 2.3 2 0 0 2 2 2 2 Fasciclin domain RskA PF10099.4 CCF39170.1 - 0.063 13.0 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Anti-sigma-K factor rskA RINGv PF12906.2 CCF39172.1 - 7.1e-05 22.7 7.3 0.00012 22.0 5.0 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.1 CCF39172.1 - 0.00042 20.0 5.5 0.00067 19.4 3.8 1.3 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.3 CCF39172.1 - 0.0011 18.9 3.9 0.002 18.0 2.7 1.4 1 0 0 1 1 1 1 FANCL C-terminal domain DUF1537 PF07005.6 CCF39172.1 - 0.015 15.0 1.3 0.022 14.4 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF1537 zf-rbx1 PF12678.2 CCF39172.1 - 0.12 12.5 4.6 0.22 11.6 3.2 1.4 1 0 0 1 1 1 0 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 CCF39172.1 - 0.17 11.5 4.0 0.3 10.7 2.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.1 CCF39172.1 - 0.45 10.1 4.6 0.87 9.2 3.2 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Abhydrolase_2 PF02230.11 CCF39173.1 - 8.9e-26 90.6 0.0 1.4e-17 63.9 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 CCF39173.1 - 0.0052 16.5 0.0 0.0073 16.0 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF39173.1 - 0.029 14.2 0.1 0.1 12.4 0.0 2.0 1 1 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF39173.1 - 0.038 13.1 0.1 0.14 11.3 0.0 1.9 1 1 0 1 1 1 0 Prolyl oligopeptidase family DUF3505 PF12013.3 CCF39174.1 - 1.3e-13 51.1 0.0 2.3e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3505) zf-H2C2_5 PF13909.1 CCF39174.1 - 0.0064 16.6 4.2 0.022 14.9 1.5 2.4 2 0 0 2 2 2 1 C2H2-type zinc-finger domain RNA_POL_M_15KD PF02150.11 CCF39174.1 - 0.041 13.5 0.1 1.9 8.2 0.0 2.6 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit Abhydrolase_4 PF08386.5 CCF39175.1 - 2.9e-20 72.0 0.0 6.3e-20 70.9 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.15 CCF39175.1 - 6.1e-18 65.2 0.0 5.5e-15 55.5 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF39175.1 - 1.8e-09 37.8 1.0 7.9e-08 32.4 0.7 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF39175.1 - 0.013 15.2 0.0 2.2 8.0 0.0 2.4 2 0 0 2 2 2 0 Alpha/beta hydrolase family p450 PF00067.17 CCF39176.1 - 2.4e-39 135.1 0.0 3.1e-39 134.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ApbA_C PF08546.6 CCF39176.1 - 0.018 15.0 0.0 0.049 13.6 0.0 1.6 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA C terminal Cerato-platanin PF07249.7 CCF39177.1 - 9.7e-55 183.6 2.8 1.1e-54 183.4 1.9 1.0 1 0 0 1 1 1 1 Cerato-platanin GHMP_kinases_N PF00288.21 CCF39178.1 - 0.011 15.8 0.0 0.021 14.8 0.0 1.5 1 0 0 1 1 1 0 GHMP kinases N terminal domain CKS PF01111.14 CCF39179.1 - 3.2e-34 116.5 0.7 4.3e-34 116.1 0.5 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Bromodomain PF00439.20 CCF39180.1 - 4.9e-33 112.8 0.1 1.6e-15 56.7 0.0 2.4 2 0 0 2 2 2 2 Bromodomain Nop14 PF04147.7 CCF39180.1 - 0.0073 14.2 11.2 0.011 13.6 7.8 1.2 1 0 0 1 1 1 1 Nop14-like family PPP4R2 PF09184.6 CCF39180.1 - 0.058 12.9 10.4 0.11 11.9 7.2 1.5 1 0 0 1 1 1 0 PPP4R2 CDC45 PF02724.9 CCF39180.1 - 1.5 6.8 10.1 2.1 6.2 7.0 1.2 1 0 0 1 1 1 0 CDC45-like protein TRAP_alpha PF03896.11 CCF39180.1 - 6 5.7 10.9 9.7 5.0 7.6 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Peptidase_M24 PF00557.19 CCF39181.1 - 3.3e-09 36.6 0.0 4.4e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Chorismate_synt PF01264.16 CCF39182.1 - 1.5e-126 421.5 0.0 1.9e-126 421.2 0.0 1.1 1 0 0 1 1 1 1 Chorismate synthase BPL_LplA_LipB PF03099.14 CCF39183.1 - 2.1e-13 50.4 0.0 4e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family TLD PF07534.11 CCF39183.1 - 0.13 12.1 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 TLD DUF788 PF05620.6 CCF39184.1 - 3.2e-42 144.2 0.0 3.6e-42 144.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF788) DUF3605 PF12239.3 CCF39185.1 - 8.1e-58 194.7 0.0 9.8e-58 194.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) EBP PF05241.7 CCF39186.1 - 4.1e-62 208.6 13.6 4.9e-62 208.4 9.4 1.0 1 0 0 1 1 1 1 Emopamil binding protein GAS2 PF02187.12 CCF39187.1 - 7e-05 22.5 0.0 0.00015 21.4 0.0 1.4 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain DUF1732 PF08340.6 CCF39187.1 - 0.18 11.6 0.0 0.41 10.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1732) Fungal_trans_2 PF11951.3 CCF39188.1 - 2.7e-20 72.3 0.6 3.8e-20 71.8 0.4 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF39188.1 - 7.2e-08 32.2 5.2 1e-07 31.7 3.6 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Methyltransf_2 PF00891.13 CCF39189.1 - 7.8e-27 94.0 0.0 1.1e-26 93.5 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Rrf2 PF02082.15 CCF39189.1 - 0.054 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator MarR_2 PF12802.2 CCF39189.1 - 0.1 12.3 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 MarR family HTH_27 PF13463.1 CCF39189.1 - 0.14 12.5 0.0 0.27 11.5 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain ATP-synt_G PF04718.10 CCF39191.1 - 0.033 14.8 0.1 0.057 14.0 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial ATP synthase g subunit Peptidase_S10 PF00450.17 CCF39192.1 - 5.9e-49 167.3 0.0 7.4e-49 167.0 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Aha1_N PF09229.6 CCF39193.1 - 1.7e-39 134.7 0.4 2.1e-39 134.4 0.3 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal OMS28_porin PF03532.8 CCF39193.1 - 0.046 12.7 0.2 0.064 12.3 0.1 1.2 1 0 0 1 1 1 0 OMS28 porin TNV_CP PF03898.8 CCF39193.1 - 0.046 12.7 0.1 0.08 11.9 0.0 1.3 1 0 0 1 1 1 0 Satellite tobacco necrosis virus coat protein ThiF PF00899.16 CCF39194.1 - 6.2e-30 103.7 0.0 9.6e-30 103.1 0.0 1.3 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.15 CCF39194.1 - 0.015 15.3 0.0 0.052 13.6 0.0 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Glycophorin_A PF01102.13 CCF39195.1 - 0.00019 21.1 1.0 0.00078 19.2 0.7 2.0 1 0 0 1 1 1 1 Glycophorin A TMEM154 PF15102.1 CCF39195.1 - 0.015 15.0 0.2 0.032 13.9 0.1 1.5 1 0 0 1 1 1 0 TMEM154 protein family Herpes_gE PF02480.11 CCF39195.1 - 0.13 10.4 0.0 0.2 9.8 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Plasmodium_Vir PF05795.6 CCF39195.1 - 0.2 10.7 0.1 0.36 9.9 0.0 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein HAD PF12710.2 CCF39197.1 - 4.6e-18 66.0 0.0 6.6e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CCF39197.1 - 3.8e-10 40.5 1.3 1.7e-08 35.1 0.9 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CCF39197.1 - 3.5e-07 30.0 1.7 1.6e-06 27.9 0.1 2.3 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 CCF39197.1 - 0.00018 21.7 0.0 0.00044 20.5 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DUF705 PF05152.7 CCF39197.1 - 0.00086 18.3 0.1 0.0013 17.7 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF705) Put_Phosphatase PF06888.7 CCF39197.1 - 0.19 10.8 0.0 11 5.1 0.0 2.2 2 0 0 2 2 2 0 Putative Phosphatase Gpi16 PF04113.9 CCF39198.1 - 1.2e-236 786.1 0.0 1.5e-236 785.8 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component LUC7 PF03194.10 CCF39199.1 - 1.4e-69 234.4 1.1 1.7e-69 234.1 0.7 1.0 1 0 0 1 1 1 1 LUC7 N_terminus BEX PF04538.7 CCF39199.1 - 0.024 14.8 0.3 0.1 12.8 0.2 2.0 1 1 0 1 1 1 0 Brain expressed X-linked like family Occludin_ELL PF07303.8 CCF39199.1 - 0.57 10.9 5.1 0.2 12.4 0.4 2.3 2 1 1 3 3 3 0 Occludin homology domain Zn_clus PF00172.13 CCF39200.1 - 1.8e-08 34.1 10.7 2.8e-08 33.5 7.4 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF39200.1 - 0.0071 14.9 0.4 0.011 14.4 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain IF4E PF01652.13 CCF39201.1 - 1.3e-48 164.6 0.8 1.6e-48 164.3 0.6 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E MFS_1 PF07690.11 CCF39204.1 - 6.8e-12 44.7 34.6 6.8e-12 44.7 24.0 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Myb_Cef PF11831.3 CCF39205.1 - 2.5e-60 203.5 7.0 2.5e-60 203.5 4.8 3.5 4 0 0 4 4 4 1 pre-mRNA splicing factor component Myb_DNA-bind_6 PF13921.1 CCF39205.1 - 1.5e-21 76.2 8.3 5e-15 55.3 2.3 3.8 2 1 1 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 CCF39205.1 - 1.9e-21 75.8 4.7 2.5e-10 40.2 0.3 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain TFIIA PF03153.8 CCF39207.1 - 0.29 10.9 4.6 0.31 10.9 3.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4149 PF13664.1 CCF39208.1 - 1.8e-19 69.6 3.4 2e-19 69.5 1.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) Ku PF02735.11 CCF39209.1 - 9.1e-26 90.5 0.0 1.6e-25 89.7 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.10 CCF39209.1 - 4.2e-24 85.2 0.0 1.1e-23 83.8 0.0 1.6 2 0 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_PK_bind PF08785.6 CCF39209.1 - 7.9e-12 45.1 0.0 2e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 Ku C terminal domain like VWA_2 PF13519.1 CCF39209.1 - 2.4e-05 24.4 0.0 5.7e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 CCF39209.1 - 0.0086 15.8 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain PAP_RNA-bind PF04926.10 CCF39210.1 - 0.059 12.8 0.3 0.2 11.1 0.1 1.9 2 1 0 2 2 2 0 Poly(A) polymerase predicted RNA binding domain Semialdhyde_dh PF01118.19 CCF39210.1 - 0.096 12.9 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DnaJ PF00226.26 CCF39211.1 - 9.7e-08 31.6 0.0 1.3e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.8 CCF39211.1 - 1.2e-06 28.3 0.0 1.4e-06 28.0 0.0 1.2 1 1 0 1 1 1 1 Pam16 DUF3918 PF13056.1 CCF39211.1 - 0.029 13.6 3.1 0.043 13.1 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3918) TMP_2 PF06791.8 CCF39211.1 - 0.11 12.0 0.1 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Prophage tail length tape measure protein Ribosomal_L24e PF01246.15 CCF39212.1 - 2.9e-29 100.7 3.0 5.5e-29 99.8 2.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L24e Occludin_ELL PF07303.8 CCF39214.1 - 0.027 15.1 4.4 0.027 15.1 3.1 4.7 2 2 3 5 5 5 0 Occludin homology domain CorA PF01544.13 CCF39214.1 - 1.7 7.6 7.0 4.5 6.2 4.8 1.7 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF4041 PF13250.1 CCF39214.1 - 1.8 8.1 6.9 3.5 7.2 0.1 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4041) BAG PF02179.11 CCF39214.1 - 2.1 8.5 22.1 0.038 14.0 1.5 4.3 3 1 0 4 4 4 0 BAG domain Reo_sigmaC PF04582.7 CCF39214.1 - 6 5.9 5.9 0.97 8.5 1.1 1.9 2 0 0 2 2 2 0 Reovirus sigma C capsid protein GTP_cyclohydro2 PF00925.15 CCF39215.1 - 0.073 12.3 0.2 0.81 8.9 0.2 2.0 1 1 1 2 2 2 0 GTP cyclohydrolase II Ku PF02735.11 CCF39216.1 - 7.5e-40 136.4 0.0 1.3e-39 135.7 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_C PF03730.9 CCF39216.1 - 3.7e-15 56.2 0.6 7.7e-15 55.2 0.4 1.5 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm Ku_N PF03731.10 CCF39216.1 - 5.7e-13 48.8 0.1 8.1e-13 48.3 0.1 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain SAP PF02037.22 CCF39216.1 - 7.5e-12 44.4 0.1 3.5e-11 42.3 0.1 2.1 2 0 0 2 2 2 1 SAP domain GMC_oxred_C PF05199.8 CCF39217.1 - 6.8e-21 75.0 0.0 7.9e-21 74.8 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase Amidohydro_4 PF13147.1 CCF39217.1 - 0.034 14.1 0.1 0.036 14.0 0.0 1.0 1 0 0 1 1 1 0 Amidohydrolase Peptidase_M41 PF01434.13 CCF39220.1 - 6.3e-68 228.4 1.7 1e-67 227.7 1.2 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 CCF39220.1 - 6.2e-43 146.1 0.0 1.4e-42 144.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CCF39220.1 - 2.9e-05 24.8 0.0 7.4e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 CCF39220.1 - 3.5e-05 23.5 0.0 0.00012 21.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 CCF39220.1 - 4.2e-05 22.4 0.0 8.6e-05 21.4 0.0 1.5 1 0 0 1 1 1 1 TIP49 C-terminus AAA_16 PF13191.1 CCF39220.1 - 6.5e-05 22.9 1.7 0.0064 16.4 0.0 3.6 4 1 1 5 5 5 1 AAA ATPase domain AAA_22 PF13401.1 CCF39220.1 - 0.00021 21.4 0.3 0.043 13.9 0.1 3.0 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 CCF39220.1 - 0.00041 20.2 0.0 0.0012 18.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 CCF39220.1 - 0.00096 18.2 0.0 0.0018 17.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 CCF39220.1 - 0.0045 16.4 0.1 0.012 15.0 0.1 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Zeta_toxin PF06414.7 CCF39220.1 - 0.0049 15.9 1.1 0.017 14.2 0.3 2.0 1 1 1 2 2 2 1 Zeta toxin AAA_19 PF13245.1 CCF39220.1 - 0.0067 16.1 0.3 0.022 14.4 0.2 1.9 1 0 0 1 1 1 1 Part of AAA domain Mg_chelatase PF01078.16 CCF39220.1 - 0.0077 15.4 0.4 0.017 14.2 0.3 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 CCF39220.1 - 0.012 14.9 0.5 0.22 10.8 0.1 2.3 1 1 1 2 2 2 0 AAA domain AAA_2 PF07724.9 CCF39220.1 - 0.021 14.7 0.0 0.061 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_14 PF13173.1 CCF39220.1 - 0.027 14.3 0.0 0.068 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 CCF39220.1 - 0.038 13.9 0.0 0.079 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 CCF39220.1 - 0.14 11.4 0.2 0.27 10.4 0.2 1.4 1 0 0 1 1 1 0 PhoH-like protein IncA PF04156.9 CCF39221.1 - 0.002 17.7 26.6 0.002 17.7 18.5 10.3 6 3 2 10 10 10 5 IncA protein Epimerase PF01370.16 CCF39222.1 - 6.6e-10 38.8 0.1 9e-10 38.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF39222.1 - 4.5e-08 33.2 0.1 5.3e-08 33.0 0.1 1.1 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF39222.1 - 1.2e-05 24.7 0.3 1.4e-05 24.4 0.2 1.2 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.20 CCF39222.1 - 0.00023 21.0 2.8 0.00041 20.2 1.9 1.5 1 1 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.12 CCF39222.1 - 0.068 12.0 0.0 0.35 9.7 0.0 2.0 2 0 0 2 2 2 0 RmlD substrate binding domain Eno-Rase_NADH_b PF12242.3 CCF39222.1 - 0.091 12.5 0.5 0.25 11.1 0.4 1.8 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase D-ser_dehydrat PF14031.1 CCF39223.1 - 0.057 13.6 0.1 0.07 13.3 0.1 1.2 1 0 0 1 1 1 0 Putative serine dehydratase domain Methyltransf_23 PF13489.1 CCF39224.1 - 9.7e-14 51.3 0.0 2.1e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF39224.1 - 2.9e-10 40.4 0.0 6.9e-10 39.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF39224.1 - 3.4e-10 39.6 0.0 1.5e-09 37.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF39224.1 - 8.2e-09 35.8 0.0 2.6e-08 34.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF39224.1 - 5.4e-07 30.1 0.1 5.5e-06 26.9 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF39224.1 - 2.7e-06 26.6 0.0 1.4e-05 24.3 0.0 2.0 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 CCF39224.1 - 0.00012 21.2 0.0 0.00035 19.6 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_25 PF13649.1 CCF39224.1 - 0.0002 21.6 0.0 0.00088 19.6 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 CCF39224.1 - 0.0068 15.7 0.0 0.015 14.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.15 CCF39224.1 - 0.079 12.0 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Terminase_1 PF03354.10 CCF39224.1 - 0.12 10.7 3.7 0.19 10.0 2.5 1.2 1 0 0 1 1 1 0 Phage Terminase FYDLN_acid PF09538.5 CCF39224.1 - 8.4 7.0 16.8 16 6.0 8.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Aa_trans PF01490.13 CCF39226.1 - 3.5e-49 167.3 42.2 4.1e-49 167.1 29.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein COX2_TM PF02790.10 CCF39226.1 - 0.012 15.4 5.3 0.012 15.4 3.7 2.9 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain Lactonase PF10282.4 CCF39227.1 - 5.1e-58 196.7 0.1 1.4e-57 195.3 0.1 1.6 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller SBP56 PF05694.6 CCF39227.1 - 0.0014 17.2 0.0 0.66 8.4 0.0 2.3 2 0 0 2 2 2 2 56kDa selenium binding protein (SBP56) Cytochrom_D1 PF02239.11 CCF39227.1 - 0.058 11.6 0.1 3.7 5.7 0.0 2.1 1 1 1 2 2 2 0 Cytochrome D1 heme domain NAD_binding_10 PF13460.1 CCF39228.1 - 0.0026 17.7 0.0 0.0031 17.5 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding MFS_1 PF07690.11 CCF39229.1 - 8.8e-40 136.4 43.6 6.9e-26 90.7 12.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF39229.1 - 0.00016 20.4 40.5 0.0096 14.5 11.3 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter PBP1_TM PF14812.1 CCF39230.1 - 3 8.2 7.3 7.1 7.0 5.0 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sulfate_transp PF00916.15 CCF39231.1 - 4e-58 196.6 11.4 4e-58 196.6 7.9 2.1 2 0 0 2 2 2 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 CCF39231.1 - 6.7e-29 99.3 1.9 6.7e-29 99.3 1.3 3.6 3 1 1 4 4 4 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 CCF39231.1 - 4e-11 42.3 0.0 7.7e-11 41.4 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.1 CCF39231.1 - 0.013 15.4 0.0 0.057 13.4 0.0 2.0 2 0 0 2 2 2 0 STAS domain MotB_plug PF13677.1 CCF39231.1 - 1.3 8.4 4.8 4.1 6.8 3.3 1.8 1 0 0 1 1 1 0 Membrane MotB of proton-channel complex MotA/MotB Lactamase_B PF00753.22 CCF39232.1 - 1.5e-17 63.9 2.8 2.5e-17 63.1 1.9 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CCF39232.1 - 0.0012 18.4 0.2 0.0018 17.8 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain CFEM PF05730.6 CCF39233.1 - 7.2e-11 41.7 8.9 1.2e-10 41.0 6.1 1.3 1 0 0 1 1 1 1 CFEM domain FadA PF09403.5 CCF39234.1 - 4.5 7.2 9.7 20 5.2 5.1 2.3 2 0 0 2 2 2 0 Adhesion protein FadA Glyco_transf_90 PF05686.7 CCF39236.1 - 7.4e-06 24.8 0.9 0.019 13.6 0.0 3.4 3 1 0 3 3 3 2 Glycosyl transferase family 90 Terpene_synth_C PF03936.11 CCF39237.1 - 2.6e-06 26.8 0.0 3.1e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain Redoxin PF08534.5 CCF39238.1 - 1.4e-27 96.0 0.0 1.7e-27 95.7 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 CCF39238.1 - 6.8e-09 35.4 0.0 8.7e-09 35.1 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family His_Phos_2 PF00328.17 CCF39239.1 - 8.8e-91 304.8 0.1 1.2e-90 304.3 0.1 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) RimK PF08443.6 CCF39239.1 - 9e-07 28.5 0.0 1.6e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Fungal_trans PF04082.13 CCF39240.1 - 7.2e-15 54.5 0.0 1.4e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF39240.1 - 1e-06 28.4 9.5 1e-06 28.4 6.6 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ABC_tran PF00005.22 CCF39241.1 - 4.2e-31 108.0 0.0 8.7e-18 64.9 0.0 2.8 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 CCF39241.1 - 9.7e-14 51.9 0.0 6.9e-05 22.9 0.0 3.3 3 0 0 3 3 3 3 AAA domain ABC2_membrane_3 PF12698.2 CCF39241.1 - 3.9e-11 42.5 18.2 5.7e-11 42.0 12.6 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein SMC_N PF02463.14 CCF39241.1 - 1.2e-06 27.9 0.1 0.13 11.5 0.1 3.1 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 CCF39241.1 - 0.00039 19.6 0.0 0.00067 18.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 CCF39241.1 - 0.0015 18.0 0.1 0.0034 16.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain IstB_IS21 PF01695.12 CCF39241.1 - 0.0016 17.9 0.0 14 5.0 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_23 PF13476.1 CCF39241.1 - 0.0023 18.3 0.2 0.0039 17.5 0.1 1.3 1 0 0 1 1 1 1 AAA domain ABC2_membrane PF01061.19 CCF39241.1 - 0.0029 16.7 13.3 0.0029 16.7 9.2 2.0 3 0 0 3 3 3 1 ABC-2 type transporter SbcCD_C PF13558.1 CCF39241.1 - 0.0086 15.9 0.0 2.7 7.9 0.0 3.3 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.1 CCF39241.1 - 0.021 14.8 0.1 0.045 13.7 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain MutS_V PF00488.16 CCF39241.1 - 0.033 13.5 0.0 1.1 8.5 0.0 2.7 3 0 0 3 3 3 0 MutS domain V Arch_ATPase PF01637.13 CCF39241.1 - 0.044 13.4 0.0 0.14 11.8 0.0 1.7 2 0 0 2 2 2 0 Archaeal ATPase AAA_15 PF13175.1 CCF39241.1 - 0.047 12.7 0.0 2.2 7.2 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.1 CCF39241.1 - 0.1 12.5 0.0 0.27 11.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 CCF39241.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_17 PF13207.1 CCF39241.1 - 0.11 13.3 0.0 0.24 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 CCF39241.1 - 0.12 11.7 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain Ribosomal_L30 PF00327.15 CCF39241.1 - 0.12 11.9 0.0 0.3 10.6 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L30p/L7e AAA_22 PF13401.1 CCF39241.1 - 0.13 12.4 0.0 0.36 10.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain SBP_bac_8 PF13416.1 CCF39241.1 - 0.16 11.7 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein ArgK PF03308.11 CCF39241.1 - 0.2 10.3 0.0 0.34 9.6 0.0 1.2 1 0 0 1 1 1 0 ArgK protein CcmB PF03379.8 CCF39243.1 - 0.2 10.8 0.0 0.28 10.3 0.0 1.1 1 0 0 1 1 1 0 CcmB protein PGA2 PF07543.7 CCF39243.1 - 0.32 10.7 4.7 0.47 10.2 3.3 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 Transcrip_reg PF01709.15 CCF39244.1 - 2.6e-13 49.6 0.0 3.4e-13 49.2 0.0 1.0 1 0 0 1 1 1 1 Transcriptional regulator DUF2346 PF09803.4 CCF39246.1 - 0.0004 20.1 7.5 0.0043 16.8 5.2 2.1 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2346) zf-RING_4 PF14570.1 CCF39248.1 - 1.5e-20 72.4 12.2 2.2e-20 71.9 8.5 1.3 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.1 CCF39248.1 - 1.1e-07 31.3 7.2 1.7e-07 30.7 5.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.7 CCF39248.1 - 1e-06 28.1 4.6 1.1e-06 28.0 3.2 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_2 PF13639.1 CCF39248.1 - 1.8e-05 24.4 9.0 2.7e-05 23.9 6.2 1.3 1 0 0 1 1 1 1 Ring finger domain FYVE_2 PF02318.11 CCF39248.1 - 0.00037 20.3 4.4 0.00037 20.3 3.0 2.1 1 1 1 2 2 2 1 FYVE-type zinc finger zf-C3HC4 PF00097.20 CCF39248.1 - 0.0025 17.4 9.6 0.0053 16.3 6.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.9 CCF39248.1 - 0.0028 17.0 0.5 0.67 9.4 0.1 2.8 2 0 0 2 2 2 1 Rad50 zinc hook motif Baculo_IE-1 PF05290.6 CCF39248.1 - 0.0033 17.1 5.4 0.0033 17.1 3.8 1.6 2 0 0 2 2 2 1 Baculovirus immediate-early protein (IE-0) FYVE PF01363.16 CCF39248.1 - 0.0051 16.6 7.2 0.011 15.6 5.0 1.7 1 1 0 1 1 1 1 FYVE zinc finger zf-RING_5 PF14634.1 CCF39248.1 - 0.0084 15.8 9.7 0.016 14.9 6.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Pol_alpha_B_N PF08418.5 CCF39248.1 - 0.0086 15.6 1.2 0.01 15.3 0.8 1.1 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal Prok-RING_4 PF14447.1 CCF39248.1 - 0.013 14.9 9.9 0.11 12.0 3.4 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-UDP PF14569.1 CCF39248.1 - 0.036 13.8 6.3 0.078 12.7 4.3 1.6 1 1 0 1 1 1 0 Zinc-binding RING-finger APC_CDC26 PF10471.4 CCF39248.1 - 0.038 14.7 1.3 0.063 14.0 0.9 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 zf-C3HC4_2 PF13923.1 CCF39248.1 - 0.04 13.9 10.9 0.094 12.7 7.6 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CENP_C_N PF15622.1 CCF39248.1 - 0.076 12.2 4.1 0.11 11.7 2.9 1.1 1 0 0 1 1 1 0 Kinetochore assembly subunit CENP-C N-terminal zf-Apc11 PF12861.2 CCF39248.1 - 0.14 12.0 3.2 0.42 10.4 0.6 2.2 1 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF1289 PF06945.8 CCF39248.1 - 0.26 10.7 5.4 0.23 10.9 2.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1289) DZR PF12773.2 CCF39248.1 - 0.77 9.6 9.3 16 5.4 6.4 2.3 1 1 1 2 2 2 0 Double zinc ribbon zf-C3HC4_4 PF15227.1 CCF39248.1 - 1.3 8.9 12.6 19 5.2 8.8 2.3 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 CCF39248.1 - 2 8.6 7.4 37 4.5 2.7 2.4 1 1 1 2 2 2 0 RING-H2 zinc finger Complex1_30kDa PF00329.14 CCF39249.1 - 2.1e-36 124.2 0.0 3.2e-36 123.6 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit DUF2087 PF09860.4 CCF39249.1 - 0.069 12.9 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) RabGAP-TBC PF00566.13 CCF39251.1 - 2.1e-24 86.1 0.9 4.6e-24 85.0 0.6 1.6 1 1 0 1 1 1 1 Rab-GTPase-TBC domain SNF2_N PF00176.18 CCF39253.1 - 1.1e-28 99.9 0.0 1.8e-28 99.1 0.0 1.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 CCF39253.1 - 0.0015 18.4 0.0 0.0027 17.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 CCF39253.1 - 0.0076 15.9 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain AAA_34 PF13872.1 CCF39253.1 - 0.15 10.8 0.0 0.56 8.9 0.0 1.8 2 0 0 2 2 2 0 P-loop containing NTP hydrolase pore-1 TruB_N PF01509.13 CCF39254.1 - 2.1e-23 83.1 0.2 2.9e-20 72.9 0.1 3.4 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.15 CCF39254.1 - 4e-22 77.7 0.8 7.7e-22 76.8 0.6 1.5 1 0 0 1 1 1 1 PUA domain PseudoU_synth_2 PF00849.17 CCF39254.1 - 0.03 14.1 0.4 0.076 12.8 0.0 1.8 2 0 0 2 2 2 0 RNA pseudouridylate synthase Med19 PF10278.4 CCF39254.1 - 0.71 9.5 10.9 0.86 9.2 6.9 1.5 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 DUF2235 PF09994.4 CCF39255.1 - 9.7e-71 238.3 0.0 1.3e-70 237.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Abhydrolase_5 PF12695.2 CCF39255.1 - 0.042 13.6 0.0 0.061 13.0 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family HET PF06985.6 CCF39256.1 - 2.2e-08 34.3 0.1 2.6e-08 34.1 0.1 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) PTEN_C2 PF10409.4 CCF39256.1 - 0.12 12.1 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 C2 domain of PTEN tumour-suppressor protein RAI1 PF08652.6 CCF39257.1 - 5.5e-28 96.5 0.0 1.3e-27 95.3 0.0 1.7 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease Pkinase PF00069.20 CCF39258.1 - 3.5e-68 229.5 0.0 5.6e-68 228.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF39258.1 - 3.1e-48 164.1 0.0 6e-48 163.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF39258.1 - 3.5e-06 26.1 0.0 4.1e-05 22.6 0.0 2.1 2 0 0 2 2 2 1 Kinase-like DUF1602 PF07673.9 CCF39259.1 - 0.013 14.9 2.6 0.013 14.9 1.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1602) DDA1 PF10172.4 CCF39260.1 - 5 7.0 6.3 2.9 7.7 1.9 2.3 2 0 0 2 2 2 0 Det1 complexing ubiquitin ligase Mannitol_dh_C PF08125.8 CCF39261.1 - 7.2e-73 244.7 0.0 9.7e-73 244.3 0.0 1.2 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.18 CCF39261.1 - 9.2e-39 132.7 0.0 2.5e-38 131.3 0.0 1.8 1 1 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain Memo PF01875.12 CCF39262.1 - 1.3e-71 240.7 0.0 1.5e-71 240.4 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein DUF3638 PF12340.3 CCF39263.1 - 1.1e-105 351.7 0.3 2e-105 350.8 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.3 CCF39263.1 - 4e-16 57.8 0.0 8.2e-16 56.8 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) TEA PF01285.13 CCF39267.1 - 3.7e-19 69.2 0.0 9.4e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 TEA/ATTS domain family Pro_isomerase PF00160.16 CCF39269.1 - 4.7e-30 104.8 0.3 5.3e-30 104.6 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.1 CCF39269.1 - 0.036 13.8 0.0 0.051 13.4 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin domain DnaJ PF00226.26 CCF39270.1 - 2.3e-19 68.8 6.0 3.1e-17 62.0 0.3 3.2 3 0 0 3 3 3 2 DnaJ domain zf-C2H2_jaz PF12171.3 CCF39270.1 - 6.4e-09 35.7 1.6 6.4e-09 35.7 1.1 1.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CCF39270.1 - 4.6e-08 33.0 7.8 7.5e-08 32.3 1.3 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 CCF39270.1 - 4.7e-07 29.8 5.7 0.00099 19.1 1.0 2.3 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.21 CCF39270.1 - 1.2e-05 25.2 7.0 0.041 14.2 0.5 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 CCF39270.1 - 7.2e-05 22.5 6.8 0.038 13.9 0.5 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_4 PF13894.1 CCF39270.1 - 0.00074 19.6 3.3 0.39 11.1 0.3 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger CpXC PF14353.1 CCF39270.1 - 0.063 13.2 0.8 8.9 6.2 0.0 3.3 3 0 0 3 3 3 0 CpXC protein zf-H2C2_2 PF13465.1 CCF39270.1 - 0.09 13.1 0.5 7.3 7.0 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger double domain DUF3527 PF12043.3 CCF39270.1 - 0.12 11.8 4.0 0.21 11.0 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) Peptidase_C54 PF03416.14 CCF39271.1 - 5.3e-95 317.7 0.0 8.3e-95 317.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C54 DHO_dh PF01180.16 CCF39272.1 - 4.3e-68 229.4 0.7 6.6e-57 192.7 0.0 2.1 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase PcrB PF01884.12 CCF39272.1 - 8.8e-05 21.8 1.3 0.095 11.9 0.1 2.4 2 0 0 2 2 2 2 PcrB family Mpv17_PMP22 PF04117.7 CCF39273.1 - 2.1e-18 65.7 0.2 2.1e-18 65.7 0.1 1.8 2 1 0 2 2 2 1 Mpv17 / PMP22 family Glyco_hydro_71 PF03659.9 CCF39274.1 - 6e-148 492.4 4.0 6e-148 492.4 2.8 1.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 71 Pkinase PF00069.20 CCF39278.1 - 2e-63 213.9 0.0 3e-63 213.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF39278.1 - 6.7e-27 94.1 0.0 9.2e-27 93.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF39278.1 - 0.0007 18.6 0.0 0.0014 17.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 CCF39278.1 - 0.06 12.3 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CCF39278.1 - 0.063 13.0 0.2 0.59 9.8 0.0 2.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family RIO1 PF01163.17 CCF39278.1 - 0.064 12.6 0.0 0.16 11.2 0.0 1.6 2 0 0 2 2 2 0 RIO1 family GST_N_2 PF13409.1 CCF39280.1 - 1.4e-09 37.7 0.1 4.5e-09 36.1 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 CCF39280.1 - 0.0094 16.1 0.2 0.031 14.5 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain SRP9-21 PF05486.7 CCF39282.1 - 8.9e-28 95.8 0.9 1.1e-27 95.5 0.7 1.1 1 0 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) Ribonuc_red_sm PF00268.16 CCF39283.1 - 4.2e-121 403.2 2.1 5.1e-121 402.9 1.4 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain ABC_tran PF00005.22 CCF39284.1 - 1.7e-44 151.4 0.1 2.8e-33 115.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 CCF39284.1 - 2.6e-44 151.7 8.6 3.9e-44 151.1 5.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 CCF39284.1 - 5.3e-13 48.7 3.0 1.5e-05 24.3 0.4 3.5 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF39284.1 - 6.5e-07 29.6 0.0 0.13 12.2 0.0 3.3 2 1 1 3 3 3 2 AAA domain AAA_16 PF13191.1 CCF39284.1 - 4.4e-05 23.5 0.5 0.00023 21.1 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain SbcCD_C PF13558.1 CCF39284.1 - 0.00013 21.7 0.3 0.29 11.0 0.2 3.3 2 1 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA PF00004.24 CCF39284.1 - 0.00059 20.0 0.8 8.2 6.6 0.0 3.6 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.4 CCF39284.1 - 0.00073 18.2 0.2 0.013 14.1 0.0 2.4 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_22 PF13401.1 CCF39284.1 - 0.019 15.0 1.3 0.2 11.8 0.1 3.0 3 1 0 3 3 2 0 AAA domain AAA_30 PF13604.1 CCF39284.1 - 0.02 14.4 0.3 1.8 8.1 0.0 3.1 3 0 0 3 3 3 0 AAA domain DUF258 PF03193.11 CCF39284.1 - 0.029 13.5 0.0 0.054 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_25 PF13481.1 CCF39284.1 - 0.054 12.8 0.2 0.74 9.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.20 CCF39284.1 - 0.057 12.9 0.0 0.18 11.2 0.0 1.8 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_5 PF07728.9 CCF39284.1 - 0.09 12.5 0.1 0.79 9.4 0.0 2.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Renin_r PF07850.9 CCF39284.1 - 0.12 12.7 0.1 0.97 9.8 0.0 2.4 2 0 0 2 2 2 0 Renin receptor-like protein DUF2868 PF11067.3 CCF39284.1 - 8.8 5.3 7.1 8.3 5.4 0.0 2.5 3 0 0 3 3 2 0 Protein of unknown function (DUF2868) Abhydrolase_6 PF12697.2 CCF39285.1 - 1e-22 81.1 2.7 1.4e-22 80.7 1.8 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF39285.1 - 4e-13 49.3 0.2 8.5e-13 48.2 0.1 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF39285.1 - 7.2e-08 32.2 0.0 1.5e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 CCF39285.1 - 3.4e-06 26.8 0.0 7.3e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase DLH PF01738.13 CCF39285.1 - 0.0025 17.1 0.0 0.009 15.3 0.0 1.9 2 1 0 2 2 2 1 Dienelactone hydrolase family Lipase_3 PF01764.20 CCF39285.1 - 0.0039 16.8 0.1 0.007 15.9 0.1 1.4 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.8 CCF39285.1 - 0.0049 16.4 0.0 0.014 14.9 0.0 1.7 1 1 0 1 1 1 1 PGAP1-like protein Ndr PF03096.9 CCF39285.1 - 0.023 13.2 0.1 0.066 11.6 0.0 1.7 1 1 0 1 1 1 0 Ndr family UPF0227 PF05728.7 CCF39285.1 - 0.052 13.2 0.0 0.29 10.8 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Pyrid_oxidase_2 PF13883.1 CCF39287.1 - 1.7e-40 138.5 0.0 2.7e-40 137.8 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase F-box-like PF12937.2 CCF39288.1 - 0.044 13.5 0.0 0.54 10.0 0.0 2.6 2 0 0 2 2 2 0 F-box-like Ribosomal_S30 PF04758.9 CCF39289.1 - 3.1e-29 100.5 7.1 3.3e-29 100.4 4.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 RRP14 PF15459.1 CCF39291.1 - 2.2e-20 72.4 1.3 2.2e-20 72.4 0.9 4.2 5 0 0 5 5 5 2 60S ribosome biogenesis protein Rrp14 HUN PF08729.5 CCF39292.1 - 1.8e-13 50.1 1.2 4.6e-13 48.8 0.8 1.7 1 0 0 1 1 1 1 HPC2 and ubinuclein domain PIG-U PF06728.8 CCF39294.1 - 1.5e-125 419.0 25.8 1.7e-125 418.8 17.9 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Mannosyl_trans PF05007.8 CCF39294.1 - 0.00011 21.9 0.2 0.00011 21.9 0.2 1.7 1 1 0 1 1 1 1 Mannosyltransferase (PIG-M) Pescadillo_N PF06732.6 CCF39295.1 - 1.4e-114 382.1 0.4 2e-114 381.5 0.3 1.2 1 0 0 1 1 1 1 Pescadillo N-terminus BRCT PF00533.21 CCF39295.1 - 2.3e-10 40.4 0.0 1e-09 38.4 0.0 2.1 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain 3-dmu-9_3-mt PF06983.8 CCF39295.1 - 0.041 14.2 0.1 0.077 13.3 0.1 1.4 1 0 0 1 1 1 0 3-demethylubiquinone-9 3-methyltransferase DUF4404 PF14357.1 CCF39295.1 - 0.49 10.8 3.8 0.49 10.8 1.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Voldacs PF03517.8 CCF39297.1 - 7.6e-24 84.0 0.0 1.4e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling SMI1_KNR4 PF09346.5 CCF39299.1 - 2.9e-09 37.0 0.0 4.7e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) Dynamin_N PF00350.18 CCF39301.1 - 8.7e-14 51.6 0.0 6.1e-13 48.9 0.0 2.3 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 CCF39301.1 - 7e-06 25.9 0.1 0.00052 19.9 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.22 CCF39301.1 - 0.0014 18.9 0.1 0.0059 16.9 0.0 2.0 1 1 0 1 1 1 1 ABC transporter DUF258 PF03193.11 CCF39301.1 - 0.0025 17.0 0.0 0.0055 15.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 CCF39301.1 - 0.0069 15.8 0.6 0.96 8.8 0.2 2.5 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain IIGP PF05049.8 CCF39301.1 - 0.019 13.8 0.0 0.068 11.9 0.0 1.9 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) AAA_23 PF13476.1 CCF39301.1 - 0.021 15.1 9.3 0.21 11.8 0.3 3.4 3 1 0 3 3 3 0 AAA domain Miro PF08477.8 CCF39301.1 - 0.09 13.2 0.0 0.27 11.7 0.0 1.9 1 0 0 1 1 1 0 Miro-like protein Pro_racemase PF05544.6 CCF39302.1 - 0.04 12.7 0.1 0.04 12.7 0.0 1.1 1 0 0 1 1 1 0 Proline racemase Sec1 PF00995.18 CCF39303.1 - 1.9e-105 353.6 0.0 2.3e-105 353.3 0.0 1.0 1 0 0 1 1 1 1 Sec1 family AMP-binding PF00501.23 CCF39305.1 - 2.2e-145 484.2 0.3 1.5e-89 300.3 0.3 2.1 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.15 CCF39305.1 - 3.8e-63 213.1 0.4 5.6e-63 212.5 0.3 1.3 1 0 0 1 1 1 1 Condensation domain HxxPF_rpt PF13745.1 CCF39305.1 - 1.7e-21 76.3 0.1 7.2e-21 74.3 0.1 2.2 1 0 0 1 1 1 1 HxxPF-repeated domain PP-binding PF00550.20 CCF39305.1 - 2.6e-10 40.3 0.1 1e-09 38.4 0.0 2.1 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.1 CCF39305.1 - 0.0001 23.1 3.3 0.0036 18.2 0.0 3.8 2 1 1 3 3 3 1 AMP-binding enzyme C-terminal domain Peptidase_S8 PF00082.17 CCF39307.1 - 1.2e-53 182.1 2.5 2.1e-53 181.3 1.8 1.4 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.15 CCF39307.1 - 5.8e-30 102.9 1.4 1.5e-29 101.5 1.0 1.8 1 0 0 1 1 1 1 Proprotein convertase P-domain PhoD PF09423.5 CCF39308.1 - 1.3e-07 30.5 0.0 2.9e-07 29.4 0.0 1.4 1 1 0 1 1 1 1 PhoD-like phosphatase Heme_oxygenase PF01126.15 CCF39310.1 - 5.9e-07 29.2 0.0 1.1e-05 25.1 0.0 2.0 2 0 0 2 2 2 1 Heme oxygenase Peptidase_M3_N PF08439.5 CCF39310.1 - 0.0099 15.9 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 1 Oligopeptidase F WD40 PF00400.27 CCF39311.1 - 3.7e-07 29.7 0.2 0.045 13.6 0.0 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat Gmad1 PF10647.4 CCF39311.1 - 0.02 14.3 0.4 0.76 9.1 0.1 2.4 3 0 0 3 3 3 0 Lipoprotein LpqB beta-propeller domain Glyco_hydro_31 PF01055.21 CCF39312.1 - 6.4e-158 526.1 3.8 7.9e-158 525.8 2.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 7tm_2 PF00002.19 CCF39314.1 - 0.00019 20.5 10.3 0.00019 20.5 7.2 1.6 1 1 1 2 2 2 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.6 CCF39314.1 - 0.0012 17.8 3.0 0.0012 17.8 2.1 1.7 1 1 1 2 2 2 1 Slime mold cyclic AMP receptor Vma12 PF11712.3 CCF39314.1 - 0.21 11.2 1.6 1.1 8.9 0.1 2.8 3 0 0 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase EF-hand_1 PF00036.27 CCF39317.1 - 1.3e-09 36.6 0.0 0.0018 17.4 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 CCF39317.1 - 3.2e-08 33.5 0.0 5.2e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 CCF39317.1 - 1.1e-07 31.3 0.0 4e-07 29.5 0.0 1.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 CCF39317.1 - 3.3e-06 26.5 0.0 0.014 15.2 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_4 PF12763.2 CCF39317.1 - 0.0086 15.8 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand WSC PF01822.14 CCF39318.1 - 6.3e-53 176.6 38.7 2.1e-19 69.2 7.0 3.8 4 0 0 4 4 4 3 WSC domain Glyco_transf_34 PF05637.7 CCF39320.1 - 3.3e-72 242.8 0.0 4.1e-72 242.5 0.0 1.0 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.9 CCF39320.1 - 0.0024 17.2 0.0 0.67 9.2 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function, DUF273 RINGv PF12906.2 CCF39321.1 - 8.1e-10 38.5 3.2 1.6e-09 37.6 0.4 2.1 2 0 0 2 2 2 1 RING-variant domain zf-RING_2 PF13639.1 CCF39321.1 - 0.034 13.9 0.7 0.034 13.9 0.5 2.0 2 0 0 2 2 2 0 Ring finger domain ZYG-11_interact PF05884.7 CCF39321.1 - 0.23 10.5 0.4 0.37 9.8 0.3 1.2 1 0 0 1 1 1 0 Interactor of ZYG-11 Proteasome_A_N PF10584.4 CCF39322.1 - 1.9e-12 46.2 0.0 2.4e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Fungal_trans_2 PF11951.3 CCF39323.1 - 4e-05 22.4 0.0 6.1e-05 21.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain FAD_binding_4 PF01565.18 CCF39324.1 - 2.3e-20 72.5 0.1 2.7e-20 72.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Hydrolase PF00702.21 CCF39324.1 - 0.061 13.7 0.0 0.074 13.4 0.0 1.4 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Oxidored_FMN PF00724.15 CCF39325.1 - 7.7e-88 294.7 0.0 8.8e-88 294.5 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family ADH_zinc_N_2 PF13602.1 CCF39327.1 - 0.0024 18.7 0.0 0.0025 18.6 0.0 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Aldo_ket_red PF00248.16 CCF39327.1 - 0.0039 16.0 0.0 0.0043 15.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Sipho_tail PF05709.6 CCF39327.1 - 0.039 13.0 0.1 0.055 12.6 0.0 1.2 1 0 0 1 1 1 0 Phage tail protein Iso_dh PF00180.15 CCF39328.1 - 3.7e-98 328.6 0.0 6.4e-98 327.9 0.0 1.3 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Pmp3 PF01679.12 CCF39329.1 - 6.1e-06 25.8 0.2 9.4e-06 25.2 0.1 1.3 1 0 0 1 1 1 1 Proteolipid membrane potential modulator GTP_EFTU PF00009.22 CCF39330.1 - 7e-57 191.9 0.2 1.3e-56 191.0 0.2 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.1 CCF39330.1 - 1.2e-32 111.6 0.0 2.3e-32 110.6 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.13 CCF39330.1 - 2.8e-30 104.3 0.0 5.5e-30 103.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 CCF39330.1 - 3.4e-22 78.1 0.0 7.2e-22 77.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 CCF39330.1 - 1.2e-13 50.9 0.0 2.9e-13 49.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 DUF3328 PF11807.3 CCF39331.1 - 1.7e-24 86.7 0.0 2.2e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) CRAL_TRIO PF00650.15 CCF39332.1 - 3.4e-26 91.6 0.0 5e-26 91.0 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 CCF39332.1 - 2.3e-08 34.0 0.0 5.2e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Acid_PPase PF12689.2 CCF39333.1 - 1.8e-63 213.1 0.0 2.2e-63 212.9 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase HAD_2 PF13419.1 CCF39333.1 - 0.00019 21.6 0.8 0.65 10.1 0.0 3.0 1 1 2 3 3 3 2 Haloacid dehalogenase-like hydrolase NIF PF03031.13 CCF39333.1 - 0.08 12.6 0.0 0.14 11.7 0.0 1.6 1 1 0 1 1 1 0 NLI interacting factor-like phosphatase DUF1212 PF06738.7 CCF39334.1 - 4.1e-52 176.4 10.9 1.9e-49 167.7 0.4 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF1212) DUF3815 PF12821.2 CCF39334.1 - 4.8e-23 81.5 26.6 2.2e-13 50.2 0.7 4.0 4 0 0 4 4 4 3 Protein of unknown function (DUF3815) DUF2301 PF10063.4 CCF39334.1 - 0.018 15.2 3.8 0.018 15.2 2.6 2.1 2 0 0 2 2 2 0 Uncharacterized integral membrane protein (DUF2301) FA_desaturase PF00487.19 CCF39336.1 - 3.3e-21 75.9 4.6 3.9e-21 75.6 3.2 1.0 1 0 0 1 1 1 1 Fatty acid desaturase FA_desaturase PF00487.19 CCF39337.1 - 0.042 13.2 6.9 0.23 10.8 4.8 2.0 1 1 0 1 1 1 0 Fatty acid desaturase AnfG_VnfG PF03139.10 CCF39338.1 - 0.016 15.0 0.3 0.024 14.4 0.2 1.3 1 0 0 1 1 1 0 Vanadium/alternative nitrogenase delta subunit HATPase_c_3 PF13589.1 CCF39339.1 - 4.1e-15 55.6 0.0 6.8e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 CCF39339.1 - 0.00084 19.0 0.0 0.038 13.7 0.0 2.3 1 1 1 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PI3_PI4_kinase PF00454.22 CCF39341.1 - 1.7e-44 152.0 0.0 3.1e-44 151.2 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.18 CCF39341.1 - 3e-22 79.0 13.6 7.7e-22 77.7 9.4 1.6 1 0 0 1 1 1 1 FAT domain FATC PF02260.15 CCF39341.1 - 1.5e-12 46.7 0.1 4.5e-12 45.1 0.1 1.9 1 0 0 1 1 1 1 FATC domain Mac PF12464.3 CCF39342.1 - 2.4e-14 53.0 0.0 3.9e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep PF00132.19 CCF39342.1 - 3.3e-12 45.3 11.5 1e-10 40.5 1.8 3.2 4 0 0 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 CCF39342.1 - 6.2e-10 38.4 12.5 3.4e-09 36.0 1.4 3.2 3 1 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase DUF4421 PF14391.1 CCF39342.1 - 0.036 13.2 0.0 0.047 12.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4421) ACT_6 PF13740.1 CCF39342.1 - 0.061 13.0 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 ACT domain Exo5 PF09810.4 CCF39343.1 - 2.3e-109 365.5 0.0 2.7e-109 365.2 0.0 1.1 1 0 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.2 CCF39343.1 - 0.0012 18.2 0.5 0.013 14.8 0.4 2.5 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily PIG-S PF10510.4 CCF39345.1 - 7.4e-147 490.1 0.0 8.5e-147 489.9 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein PALP PF00291.20 CCF39346.1 - 1.8e-61 208.0 0.1 2.2e-61 207.7 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.23 CCF39346.1 - 4.7e-10 39.0 0.0 1.1e-07 31.4 0.0 2.6 2 0 0 2 2 2 2 CBS domain SRPRB PF09439.5 CCF39347.1 - 3e-28 98.2 0.0 6.9e-28 97.0 0.0 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 CCF39347.1 - 2.8e-05 24.0 0.0 4.5e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 CCF39347.1 - 0.0018 18.3 0.3 0.0029 17.6 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain Septin PF00735.13 CCF39347.1 - 0.0021 17.1 0.0 0.0045 16.0 0.0 1.5 2 0 0 2 2 2 1 Septin Arf PF00025.16 CCF39347.1 - 0.0021 17.3 0.0 0.12 11.6 0.0 2.5 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_22 PF13401.1 CCF39347.1 - 0.0034 17.5 0.0 0.0069 16.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 CCF39347.1 - 0.011 15.8 0.1 0.068 13.3 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) GTP_EFTU PF00009.22 CCF39347.1 - 0.013 14.9 0.0 0.13 11.7 0.0 2.0 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain SRP54 PF00448.17 CCF39347.1 - 0.016 14.6 0.1 0.92 8.9 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain cobW PF02492.14 CCF39347.1 - 0.028 13.8 0.3 2 7.8 0.2 2.2 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.22 CCF39347.1 - 0.047 13.9 0.0 0.073 13.3 0.0 1.3 1 0 0 1 1 1 0 ABC transporter Miro PF08477.8 CCF39347.1 - 0.061 13.8 0.0 0.31 11.5 0.0 2.1 2 0 0 2 2 2 0 Miro-like protein DUF258 PF03193.11 CCF39347.1 - 0.077 12.1 0.1 0.14 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Ras PF00071.17 CCF39347.1 - 0.12 11.7 0.0 0.42 10.0 0.0 1.8 2 0 0 2 2 2 0 Ras family zf-DHHC PF01529.15 CCF39348.1 - 1.2e-36 125.7 10.2 1.2e-36 125.7 7.1 1.6 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank PF00023.25 CCF39348.1 - 1e-35 119.7 0.7 1.2e-07 31.2 0.0 5.5 5 0 0 5 5 5 5 Ankyrin repeat Ank_2 PF12796.2 CCF39348.1 - 9.2e-34 115.6 0.0 7.7e-17 61.4 0.0 2.6 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 CCF39348.1 - 1.6e-27 94.8 1.0 1.9e-08 34.3 0.0 5.5 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_4 PF13637.1 CCF39348.1 - 2.3e-26 91.6 0.2 4.9e-07 30.0 0.2 4.7 2 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF39348.1 - 4.2e-23 79.1 2.3 2e-06 27.5 0.0 5.9 6 0 0 6 6 6 4 Ankyrin repeat FtsX PF02687.16 CCF39348.1 - 7 6.4 9.7 7.8 6.2 2.0 2.6 2 1 0 2 2 2 0 FtsX-like permease family DUF946 PF06101.6 CCF39350.1 - 5.6e-12 44.4 0.3 5.6e-12 44.4 0.2 1.6 2 0 0 2 2 2 1 Plant protein of unknown function (DUF946) TFIIIC_sub6 PF10419.4 CCF39351.1 - 1.2e-11 43.8 0.0 2.4e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 TFIIIC subunit Glyco_transf_8 PF01501.15 CCF39352.1 - 3.4e-08 33.1 0.0 3.6e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 SNF2_N PF00176.18 CCF39353.1 - 5.5e-55 186.2 0.1 7.7e-55 185.7 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain VIGSSK PF14773.1 CCF39353.1 - 6.1e-25 86.9 2.5 2.1e-24 85.2 1.7 2.0 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal Helicase_C PF00271.26 CCF39353.1 - 8.6e-15 54.3 0.0 1.5e-13 50.3 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF39353.1 - 6e-05 22.9 0.3 0.00077 19.3 0.0 3.0 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.3 CCF39353.1 - 0.027 13.2 0.0 0.072 11.8 0.0 1.7 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 GA PF01468.12 CCF39353.1 - 0.59 10.3 4.9 5 7.3 1.6 2.6 2 0 0 2 2 2 0 GA module TruD PF01142.13 CCF39354.1 - 6.9e-57 192.8 0.0 2.3e-51 174.6 0.0 3.3 3 0 0 3 3 3 2 tRNA pseudouridine synthase D (TruD) Pkinase PF00069.20 CCF39355.1 - 6.9e-14 51.6 0.0 8.1e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF39355.1 - 1.2e-06 27.7 0.0 1.6e-06 27.4 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF39355.1 - 0.13 11.2 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Glyco_trans_1_4 PF13692.1 CCF39356.1 - 5.7e-24 84.7 0.3 3.2e-23 82.3 0.0 2.3 3 0 0 3 3 3 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.15 CCF39356.1 - 2.3e-06 27.1 0.0 6.1e-06 25.7 0.0 1.7 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 CCF39356.1 - 0.00087 19.5 0.0 0.0018 18.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 GMC_oxred_C PF05199.8 CCF39357.1 - 1.1e-22 80.9 0.4 1.5e-22 80.4 0.3 1.2 1 1 0 1 1 1 1 GMC oxidoreductase AMP-binding PF00501.23 CCF39358.1 - 6.1e-82 275.2 0.2 8.1e-82 274.8 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.15 CCF39358.1 - 2e-58 197.6 0.0 2.8e-58 197.1 0.0 1.2 1 0 0 1 1 1 1 Condensation domain HxxPF_rpt PF13745.1 CCF39358.1 - 2.1e-21 75.9 0.6 8.3e-21 74.1 0.2 2.3 2 0 0 2 2 2 1 HxxPF-repeated domain PP-binding PF00550.20 CCF39358.1 - 2.2e-13 50.2 0.3 5.8e-13 48.8 0.2 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.1 CCF39358.1 - 5.6e-09 36.8 0.6 0.00077 20.3 0.3 3.1 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain Methyltransf_23 PF13489.1 CCF39358.1 - 1e-05 25.3 0.0 2.6e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF39358.1 - 2.8e-05 23.7 0.0 6e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF39358.1 - 6.7e-05 22.9 0.1 0.00052 20.0 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF39358.1 - 7.5e-05 23.0 0.0 0.00033 20.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF39358.1 - 0.00011 22.7 0.0 0.00036 21.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF39358.1 - 0.00011 22.6 0.0 0.00027 21.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain zf-H2C2 PF09337.5 CCF39359.1 - 0.047 13.1 0.2 0.11 11.9 0.0 1.6 2 0 0 2 2 2 0 His(2)-Cys(2) zinc finger OB_NTP_bind PF07717.11 CCF39360.1 - 8.2e-25 86.8 0.1 4e-24 84.6 0.0 2.1 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 CCF39360.1 - 2.4e-22 78.8 0.0 6.3e-22 77.5 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 CCF39360.1 - 7e-12 45.0 0.0 1.9e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 CCF39360.1 - 9.5e-08 31.7 0.2 3.8e-07 29.7 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 CCF39360.1 - 1.7e-06 28.2 0.0 4.7e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.17 CCF39360.1 - 2.2e-05 23.9 0.1 7.9e-05 22.1 0.1 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain T2SE PF00437.15 CCF39360.1 - 0.00015 20.8 0.0 0.00029 19.8 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein ResIII PF04851.10 CCF39360.1 - 0.0045 16.8 0.0 1.4 8.6 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.9 CCF39360.1 - 0.017 14.8 0.1 0.038 13.7 0.1 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain Response_reg PF00072.19 CCF39360.1 - 0.034 14.1 0.8 0.11 12.5 0.1 2.1 3 0 0 3 3 3 0 Response regulator receiver domain AAA_30 PF13604.1 CCF39360.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CCF39360.1 - 0.14 12.0 0.1 1.4 8.8 0.1 2.7 2 1 0 2 2 2 0 AAA ATPase domain Aerolysin PF01117.15 CCF39364.1 - 0.0066 15.4 2.1 0.01 14.7 1.4 1.3 1 0 0 1 1 1 1 Aerolysin toxin Exc PF07825.6 CCF39364.1 - 0.012 15.4 0.0 0.028 14.1 0.0 1.6 1 0 0 1 1 1 0 Excisionase-like protein NdhN PF11909.3 CCF39365.1 - 0.12 11.6 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 NADH-quinone oxidoreductase cyanobacterial subunit N MotA_ExbB PF01618.11 CCF39366.1 - 2.2 7.8 4.6 1.7 8.2 0.1 2.2 2 0 0 2 2 2 0 MotA/TolQ/ExbB proton channel family MIF PF01187.13 CCF39367.1 - 3.9e-11 43.0 0.0 6.2e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Gtr1_RagA PF04670.7 CCF39368.1 - 1.6e-70 236.9 0.1 1.9e-70 236.5 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 CCF39368.1 - 1.8e-05 25.2 0.0 0.0022 18.4 0.0 2.3 2 0 0 2 2 2 2 Miro-like protein Apc4 PF12896.2 CCF39369.1 - 3.8e-57 192.9 0.0 5.9e-57 192.3 0.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 WD40 PF00400.27 CCF39369.1 - 0.093 12.6 0.0 0.3 11.0 0.0 1.9 1 0 0 1 1 1 0 WD domain, G-beta repeat Adap_comp_sub PF00928.16 CCF39370.1 - 2e-16 59.8 0.1 3.4e-16 59.1 0.1 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 CCF39370.1 - 2.8e-08 33.5 0.1 4.9e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.4 CCF39370.1 - 0.00052 19.2 0.1 0.0023 17.1 0.1 2.0 1 1 0 1 1 1 1 Muniscin C-terminal mu homology domain DUF3484 PF11983.3 CCF39370.1 - 0.14 13.0 1.9 0.22 12.4 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3484) DUF2420 PF10336.4 CCF39371.1 - 6.5e-08 32.1 0.0 1.5e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Pkinase PF00069.20 CCF39373.1 - 9.5e-36 123.2 0.0 1.3e-35 122.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF39373.1 - 2.2e-15 56.4 0.0 4e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF39373.1 - 0.00032 19.7 0.0 0.00059 18.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CCF39373.1 - 0.039 13.6 0.0 0.12 12.0 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family TauD PF02668.11 CCF39374.1 - 1.7e-14 54.1 0.2 2.2e-14 53.7 0.1 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.5 CCF39374.1 - 0.015 14.2 0.0 0.02 13.8 0.0 1.1 1 0 0 1 1 1 0 CsiD Fungal_trans_2 PF11951.3 CCF39375.1 - 5.5e-29 100.9 0.7 2.7e-17 62.4 0.1 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF39375.1 - 6.5e-09 35.5 12.2 1.5e-08 34.3 8.5 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AT_hook PF02178.14 CCF39375.1 - 0.06 13.0 5.3 0.18 11.5 3.7 1.9 1 0 0 1 1 1 0 AT hook motif LAG1-DNAbind PF09271.6 CCF39375.1 - 0.074 13.5 0.1 0.32 11.4 0.0 2.0 2 0 0 2 2 2 0 LAG1, DNA binding ketoacyl-synt PF00109.21 CCF39376.1 - 9.4e-73 244.8 0.2 3.4e-72 242.9 0.0 2.1 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 CCF39376.1 - 5.3e-33 114.6 0.6 1e-32 113.7 0.3 1.5 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.17 CCF39376.1 - 2.7e-31 107.8 1.0 1.5e-30 105.4 0.0 2.6 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 CCF39376.1 - 0.00046 19.2 0.0 0.00084 18.4 0.0 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain RGS PF00615.14 CCF39378.1 - 1.7e-05 24.9 0.0 0.00014 21.9 0.0 2.1 1 1 0 1 1 1 1 Regulator of G protein signaling domain Meth_synt_2 PF01717.13 CCF39379.1 - 6e-11 41.8 0.0 1.1e-09 37.7 0.0 2.5 2 1 0 2 2 2 1 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.7 CCF39379.1 - 1.4e-05 24.5 0.1 0.0091 15.2 0.0 3.4 3 1 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain CagX PF03524.10 CCF39380.1 - 0.054 12.7 0.2 0.058 12.6 0.1 1.1 1 0 0 1 1 1 0 Conjugal transfer protein PMM PF03332.8 CCF39381.1 - 6.8e-101 336.4 0.2 7.9e-101 336.2 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.7 CCF39381.1 - 0.0015 18.1 0.0 0.011 15.3 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase RIX1 PF08167.7 CCF39384.1 - 1.2e-44 151.8 0.0 2.4e-44 150.9 0.0 1.5 1 0 0 1 1 1 1 rRNA processing/ribosome biogenesis Epimerase PF01370.16 CCF39385.1 - 3.2e-16 59.4 0.0 5.3e-16 58.7 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF39385.1 - 4.5e-14 52.8 0.0 7.5e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 CCF39385.1 - 5.2e-13 48.3 0.0 8.8e-13 47.5 0.0 1.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.8 CCF39385.1 - 1.6e-07 30.8 0.0 2.7e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.7 CCF39385.1 - 1.5e-06 27.2 0.1 1.6e-05 23.9 0.1 2.0 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 CCF39385.1 - 1.5e-05 24.9 0.5 9e-05 22.4 0.0 2.3 2 1 0 2 2 2 1 short chain dehydrogenase Polysacc_synt_2 PF02719.10 CCF39385.1 - 0.00031 19.7 0.0 0.00054 18.9 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.12 CCF39385.1 - 0.011 14.6 0.0 0.067 12.0 0.0 2.1 2 1 0 2 2 2 0 RmlD substrate binding domain DNA_pol_A_exo1 PF01612.15 CCF39387.1 - 5.8e-43 146.4 0.3 9.3e-43 145.7 0.2 1.3 1 0 0 1 1 1 1 3'-5' exonuclease HRDC PF00570.18 CCF39387.1 - 1.4e-12 47.1 0.1 9.5e-12 44.4 0.0 2.4 1 1 1 2 2 2 1 HRDC domain FliJ PF02050.11 CCF39387.1 - 0.72 9.9 28.2 1.5 8.9 19.5 1.5 1 0 0 1 1 1 0 Flagellar FliJ protein Borrelia_P83 PF05262.6 CCF39387.1 - 1.8 6.7 36.9 2.9 6.0 25.6 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein 2-Hacid_dh PF00389.25 CCF39388.1 - 6e-18 64.5 0.0 7e-18 64.3 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 2-Hacid_dh_C PF02826.14 CCF39388.1 - 5.2e-14 51.7 0.0 1e-13 50.8 0.0 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.12 CCF39388.1 - 2.4e-05 24.6 0.0 5.8e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.7 CCF39388.1 - 0.00013 21.3 0.0 0.00025 20.4 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_10 PF13460.1 CCF39388.1 - 0.0017 18.4 0.1 0.0069 16.4 0.0 1.8 2 0 0 2 2 2 1 NADH(P)-binding NAD_binding_2 PF03446.10 CCF39388.1 - 0.0043 16.8 0.0 0.0095 15.7 0.0 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.13 CCF39388.1 - 0.0083 15.7 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XdhC_C PF13478.1 CCF39388.1 - 0.045 14.0 0.0 0.094 13.0 0.0 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain Saccharop_dh PF03435.13 CCF39388.1 - 0.093 11.6 0.0 0.19 10.6 0.0 1.5 2 0 0 2 2 2 0 Saccharopine dehydrogenase NAD_Gly3P_dh_N PF01210.18 CCF39388.1 - 0.11 12.1 0.1 0.72 9.5 0.0 2.1 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus MFS_1 PF07690.11 CCF39389.1 - 5.6e-50 170.0 54.6 2.1e-49 168.1 37.9 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF39389.1 - 5.7e-20 71.0 22.4 1e-18 66.9 12.5 2.2 1 1 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 CCF39389.1 - 1.2e-16 60.4 9.1 1.2e-16 60.4 6.3 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter Kinocilin PF15033.1 CCF39389.1 - 0.63 9.5 7.6 0.77 9.3 0.3 3.3 3 1 0 3 3 3 0 Kinocilin protein WD40 PF00400.27 CCF39390.1 - 1.9e-25 87.7 7.7 1.4e-07 31.1 0.1 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.3 CCF39390.1 - 0.00035 18.8 2.3 0.0012 17.0 0.3 2.3 1 1 0 2 2 2 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 CCF39390.1 - 0.013 14.2 0.0 4.7 5.8 0.0 3.4 1 1 1 3 3 3 0 Nup133 N terminal like Cyclin_N PF00134.18 CCF39390.1 - 0.13 11.8 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain OB_NTP_bind PF07717.11 CCF39391.1 - 4.4e-26 90.9 0.0 3.1e-24 85.0 0.0 2.8 3 0 0 3 3 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 CCF39391.1 - 8.1e-26 90.0 0.0 8.1e-26 90.0 0.0 3.1 4 0 0 4 4 3 1 Helicase associated domain (HA2) Helicase_C PF00271.26 CCF39391.1 - 6.4e-13 48.3 0.0 1.8e-12 46.9 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 CCF39391.1 - 1.5e-07 31.0 0.0 3.6e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 CCF39391.1 - 0.00042 20.1 0.9 0.27 11.0 0.0 3.0 3 0 0 3 3 2 2 Type III restriction enzyme, res subunit AAA_22 PF13401.1 CCF39391.1 - 0.00047 20.3 0.0 0.0011 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 CCF39391.1 - 0.00057 18.8 0.0 0.0011 17.9 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF2075 PF09848.4 CCF39391.1 - 0.00069 18.6 0.0 0.0013 17.7 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) SRP54 PF00448.17 CCF39391.1 - 0.0025 17.2 0.0 0.0053 16.2 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain KaiC PF06745.8 CCF39391.1 - 0.0053 15.9 0.0 0.011 14.8 0.0 1.5 1 0 0 1 1 1 1 KaiC Flavi_DEAD PF07652.9 CCF39391.1 - 0.014 15.1 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain GAD PF02938.9 CCF39391.1 - 0.027 14.6 0.0 0.067 13.3 0.0 1.6 1 0 0 1 1 1 0 GAD domain AAA_10 PF12846.2 CCF39391.1 - 0.041 13.3 0.4 7.5 5.8 0.1 2.3 2 0 0 2 2 2 0 AAA-like domain Myosin_head PF00063.16 CCF39391.1 - 0.055 11.5 0.0 0.1 10.6 0.0 1.3 1 0 0 1 1 1 0 Myosin head (motor domain) AAA_14 PF13173.1 CCF39391.1 - 0.063 13.1 0.2 0.42 10.5 0.1 2.2 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 CCF39391.1 - 0.066 13.5 0.0 0.22 11.7 0.0 2.0 1 0 0 1 1 1 0 ABC transporter AAA_25 PF13481.1 CCF39391.1 - 0.066 12.6 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 CCF39391.1 - 0.14 11.8 0.4 0.61 9.7 0.1 2.1 2 0 0 2 2 2 0 NACHT domain DUF4360 PF14273.1 CCF39392.1 - 3.7e-18 65.8 0.2 4.2e-18 65.6 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) Phage_Gp111 PF07410.6 CCF39393.1 - 0.026 14.6 0.0 0.041 14.0 0.0 1.4 1 0 0 1 1 1 0 Streptococcus thermophilus bacteriophage Gp111 protein Ribosomal_S9 PF00380.14 CCF39395.1 - 1.5e-33 115.6 0.1 1.7e-33 115.3 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Nckap1 PF09735.4 CCF39395.1 - 0.021 12.3 0.0 0.022 12.2 0.0 1.0 1 0 0 1 1 1 0 Membrane-associated apoptosis protein Uds1 PF15456.1 CCF39396.1 - 9.3e-36 122.5 6.4 3.9e-35 120.5 4.4 2.1 1 0 0 1 1 1 1 Up-regulated During Septation TBPIP PF07106.8 CCF39396.1 - 0.88 9.1 3.8 0.96 8.9 1.1 2.0 2 1 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) LIM_bind PF01803.11 CCF39397.1 - 4.5e-81 271.4 0.0 4.5e-81 271.4 0.0 4.1 2 1 1 3 3 3 1 LIM-domain binding protein LMBR1 PF04791.11 CCF39397.1 - 7.7 4.9 4.4 9.6 4.6 3.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein FLO_LFY PF01698.11 CCF39397.1 - 9.1 5.0 20.1 19 3.9 14.0 1.6 1 0 0 1 1 1 0 Floricaula / Leafy protein Serinc PF03348.10 CCF39398.1 - 6.8e-175 581.8 4.7 8.4e-175 581.5 3.2 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) Aldo_ket_red PF00248.16 CCF39399.1 - 5.6e-63 212.4 0.0 6.3e-63 212.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Cir_N PF10197.4 CCF39400.1 - 2.8e-05 24.0 2.0 2.8e-05 24.0 1.4 4.7 4 1 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR SIR2 PF02146.12 CCF39402.1 - 1.1e-28 100.1 0.3 9.4e-18 64.5 0.0 2.1 2 0 0 2 2 2 2 Sir2 family TTL PF03133.10 CCF39404.1 - 1.2e-36 126.1 0.0 5.2e-36 124.0 0.0 1.8 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 CCF39404.1 - 0.013 14.3 0.0 0.028 13.2 0.0 1.5 1 0 0 1 1 1 0 YheC/D like ATP-grasp Dala_Dala_lig_C PF07478.8 CCF39404.1 - 0.035 13.4 0.0 0.094 12.0 0.0 1.6 2 0 0 2 2 2 0 D-ala D-ala ligase C-terminus HAUS6_N PF14661.1 CCF39405.1 - 5.2e-56 189.7 1.4 1.2e-55 188.5 0.9 1.5 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus PWI PF01480.12 CCF39407.1 - 1.4e-10 41.1 1.1 2.3e-10 40.3 0.2 1.9 2 0 0 2 2 2 1 PWI domain Nuc_sug_transp PF04142.10 CCF39408.1 - 1.2e-40 139.2 2.4 1.5e-40 138.8 1.7 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.6 CCF39408.1 - 0.00067 18.6 2.3 0.0008 18.4 0.5 1.9 2 0 0 2 2 2 1 UAA transporter family EmrE PF13536.1 CCF39408.1 - 0.0011 19.1 2.0 0.0011 19.1 1.4 2.9 3 1 0 3 3 3 1 Multidrug resistance efflux transporter Phage_holin_5 PF06946.6 CCF39408.1 - 0.013 15.6 1.3 0.033 14.3 0.1 2.2 2 0 0 2 2 2 0 Phage holin TPT PF03151.11 CCF39408.1 - 0.038 13.6 5.7 0.78 9.3 0.2 2.6 2 1 0 2 2 2 0 Triose-phosphate Transporter family DUF872 PF05915.7 CCF39408.1 - 0.056 13.2 1.1 0.15 11.8 0.0 2.2 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF872) EamA PF00892.15 CCF39408.1 - 0.066 13.2 0.7 0.066 13.2 0.5 3.3 3 1 0 3 3 3 0 EamA-like transporter family Lactamase_B PF00753.22 CCF39409.1 - 1.3e-08 34.7 0.3 1.7e-08 34.3 0.2 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily FYVE_2 PF02318.11 CCF39409.1 - 0.054 13.4 0.1 0.094 12.6 0.1 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger DUF3967 PF13152.1 CCF39409.1 - 0.14 11.8 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3967) AA_permease PF00324.16 CCF39410.1 - 6.7e-109 364.3 37.0 8.5e-109 364.0 25.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF39410.1 - 3.2e-20 72.0 39.6 4.4e-20 71.6 27.5 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3487 PF11990.3 CCF39410.1 - 0.35 10.2 0.0 0.35 10.2 0.0 4.3 4 0 0 4 4 4 0 Protein of unknown function (DUF3487) SET PF00856.23 CCF39412.1 - 1.1e-08 35.4 0.0 3.4e-08 33.9 0.0 1.8 1 1 0 1 1 1 1 SET domain Epimerase PF01370.16 CCF39413.1 - 9.3e-21 74.3 0.0 1.4e-20 73.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF39413.1 - 5.6e-14 51.5 0.0 9.1e-14 50.8 0.0 1.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 CCF39413.1 - 2.1e-12 47.4 2.9 5.7e-12 46.0 2.1 1.7 1 1 1 2 2 2 1 NADH(P)-binding NAD_binding_4 PF07993.7 CCF39413.1 - 2.4e-12 46.3 0.0 6.4e-12 44.9 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 CCF39413.1 - 9.3e-09 35.4 0.8 2.2e-08 34.2 0.6 1.6 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.10 CCF39413.1 - 8.3e-08 31.4 0.0 1.6e-07 30.5 0.0 1.4 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.5 CCF39413.1 - 4.4e-07 29.7 0.2 7.1e-07 29.0 0.2 1.3 1 0 0 1 1 1 1 KR domain F420_oxidored PF03807.12 CCF39413.1 - 0.00096 19.5 0.0 0.0036 17.7 0.0 2.0 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NmrA PF05368.8 CCF39413.1 - 0.0025 17.0 0.4 0.0063 15.7 0.2 1.7 1 1 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.12 CCF39413.1 - 0.012 14.5 0.1 0.1 11.4 0.0 2.3 2 1 1 3 3 3 0 RmlD substrate binding domain Saccharop_dh PF03435.13 CCF39413.1 - 0.028 13.3 0.1 0.077 11.9 0.1 1.7 1 1 1 2 2 2 0 Saccharopine dehydrogenase SpoU_sub_bind PF08032.7 CCF39413.1 - 0.12 12.5 0.0 0.48 10.6 0.0 2.0 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding PRTase_2 PF15609.1 CCF39414.1 - 0.14 11.4 0.0 0.14 11.4 0.0 1.7 2 0 0 2 2 2 0 Phosphoribosyl transferase RFC1 PF08519.7 CCF39415.1 - 0.097 12.4 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Replication factor RFC1 C terminal domain Acetyltransf_1 PF00583.19 CCF39416.1 - 1.2e-06 28.4 0.0 2e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 CCF39416.1 - 4.4e-05 23.5 0.0 0.00025 21.1 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 CCF39416.1 - 6.6e-05 23.0 0.0 0.00013 22.0 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF39416.1 - 0.00088 18.9 0.0 0.0025 17.5 0.0 1.7 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_9 PF13527.1 CCF39416.1 - 0.088 12.6 0.0 0.73 9.6 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain HsbA PF12296.3 CCF39417.1 - 7.8e-13 48.3 4.2 1.1e-12 47.9 2.9 1.2 1 0 0 1 1 1 1 Hydrophobic surface binding protein A zf-C2H2_4 PF13894.1 CCF39418.1 - 4.1e-05 23.6 9.7 0.0013 18.8 0.9 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF39418.1 - 0.0011 19.1 13.3 0.017 15.3 1.9 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CCF39418.1 - 0.0076 16.5 3.0 0.0076 16.5 2.1 2.9 3 0 0 3 3 3 1 Zinc-finger double domain zf-met PF12874.2 CCF39418.1 - 0.026 14.7 5.6 0.38 11.0 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Integrin_B_tail PF07965.7 CCF39418.1 - 0.029 14.7 0.6 0.06 13.7 0.1 1.6 1 1 1 2 2 2 0 Integrin beta tail domain ATP_bind_3 PF01171.15 CCF39419.1 - 3.9e-41 140.5 0.0 1.3e-28 99.6 0.0 2.3 2 0 0 2 2 2 2 PP-loop family Asn_synthase PF00733.16 CCF39419.1 - 0.0013 18.3 0.1 0.0032 16.9 0.0 1.7 2 0 0 2 2 2 1 Asparagine synthase Mito_carr PF00153.22 CCF39420.1 - 3.1e-48 161.4 7.2 9.1e-19 66.9 0.2 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein TcpQ PF10671.4 CCF39420.1 - 0.024 14.5 0.1 0.067 13.0 0.1 1.6 2 0 0 2 2 2 0 Toxin co-regulated pilus biosynthesis protein Q VWA_2 PF13519.1 CCF39421.1 - 3.9e-08 33.5 0.0 4.3e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 CCF39421.1 - 2.1e-07 30.8 0.0 2.7e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.1 CCF39421.1 - 0.0063 16.2 0.0 2.1 8.0 0.0 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_CoxE PF05762.9 CCF39421.1 - 0.11 11.6 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein SUV3_C PF12513.3 CCF39422.1 - 4.2e-15 54.9 0.6 1.1e-14 53.5 0.1 2.0 2 0 0 2 2 2 1 Mitochondrial degradasome RNA helicase subunit C terminal MIT PF04212.13 CCF39422.1 - 0.8 9.6 3.7 3.3 7.6 0.9 2.6 1 1 1 2 2 2 0 MIT (microtubule interacting and transport) domain Peptidase_C12 PF01088.16 CCF39423.1 - 2.8e-61 206.4 0.0 3.4e-61 206.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Glyoxalase_2 PF12681.2 CCF39423.1 - 0.0069 16.9 0.0 0.011 16.3 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase-like domain DAHP_synth_1 PF00793.15 CCF39425.1 - 1.3e-19 69.9 0.0 1.6e-19 69.6 0.0 1.2 1 0 0 1 1 1 1 DAHP synthetase I family Far-17a_AIG1 PF04750.9 CCF39426.1 - 5.8e-53 179.0 9.6 6.7e-53 178.8 6.6 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein DUF3185 PF11381.3 CCF39426.1 - 0.027 14.2 1.4 0.027 14.2 1.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3185) ATP1G1_PLM_MAT8 PF02038.11 CCF39426.1 - 1.8 7.6 4.7 0.39 9.7 0.2 2.1 3 0 0 3 3 3 0 ATP1G1/PLM/MAT8 family WD40 PF00400.27 CCF39427.1 - 3.1e-14 52.2 1.5 4e-07 29.6 0.0 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat She2p PF11435.3 CCF39427.1 - 0.12 11.7 0.4 0.69 9.2 0.0 2.1 2 0 0 2 2 2 0 RNA binding protein She2p zf-C2H2_4 PF13894.1 CCF39428.1 - 0.0098 16.1 2.5 3.1 8.3 0.0 3.0 2 1 0 2 2 2 2 C2H2-type zinc finger Cyt-b5 PF00173.23 CCF39431.1 - 2.1e-14 53.0 0.0 2.5e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TPR_12 PF13424.1 CCF39432.1 - 1.7e-12 47.1 0.5 5.7e-05 22.9 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.1 CCF39432.1 - 3.7e-05 23.2 2.0 1.8 8.2 0.0 3.7 3 1 0 3 3 3 2 TPR repeat TPR_2 PF07719.12 CCF39432.1 - 7.5e-05 22.3 1.0 0.14 12.1 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 CCF39432.1 - 0.0061 16.1 0.7 11 5.8 0.1 4.0 3 1 0 3 3 3 1 Tetratricopeptide repeat Gloverin PF10793.4 CCF39432.1 - 0.0076 15.9 0.1 0.013 15.1 0.1 1.4 1 0 0 1 1 1 1 Gloverin-like protein RPN7 PF10602.4 CCF39432.1 - 0.019 14.3 0.4 1.2 8.5 0.0 2.6 3 0 0 3 3 3 0 26S proteasome subunit RPN7 TPR_7 PF13176.1 CCF39432.1 - 0.02 14.6 0.2 47 4.1 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat Apc3 PF12895.2 CCF39432.1 - 0.095 12.8 0.0 0.28 11.3 0.0 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 CCF39432.1 - 0.18 11.6 1.0 13 5.8 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat ADH_N PF08240.7 CCF39434.1 - 1.5e-22 79.4 3.5 2.4e-22 78.7 2.4 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF39434.1 - 7.1e-17 61.1 0.0 1.7e-16 59.9 0.0 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF39434.1 - 6.3e-05 23.8 0.0 0.00014 22.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_18 PF12847.2 CCF39434.1 - 0.00038 21.0 0.0 0.0014 19.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain 2-Hacid_dh_C PF02826.14 CCF39434.1 - 0.017 14.2 0.0 0.03 13.4 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain XdhC_C PF13478.1 CCF39434.1 - 0.04 14.2 0.0 0.17 12.2 0.0 1.9 2 0 0 2 2 2 0 XdhC Rossmann domain Shikimate_DH PF01488.15 CCF39434.1 - 0.044 13.8 0.0 0.16 12.0 0.0 2.0 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase MTS PF05175.9 CCF39434.1 - 0.12 11.7 0.0 0.23 10.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain PDEase_I PF00233.14 CCF39435.1 - 1.1e-43 149.7 2.5 4.8e-41 141.0 0.1 2.2 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase MOR2-PAG1_N PF14222.1 CCF39436.1 - 1.8e-220 733.3 0.0 2.4e-220 732.9 0.0 1.1 1 0 0 1 1 1 1 Cell morphogenesis N-terminal CRM1_C PF08767.6 CCF39436.1 - 0.09 11.6 0.2 0.17 10.7 0.1 1.3 1 0 0 1 1 1 0 CRM1 C terminal Bgal_small_N PF02929.12 CCF39437.1 - 4.4e-48 163.6 0.1 1.4e-47 162.0 0.0 1.7 1 1 0 1 1 1 1 Beta galactosidase small chain Mito_carr PF00153.22 CCF39439.1 - 1.6e-39 133.4 3.1 1.9e-14 53.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein RibD_C PF01872.12 CCF39440.1 - 1.7e-35 122.4 0.0 2e-35 122.2 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain Transp_cyt_pur PF02133.10 CCF39441.1 - 5.8e-19 67.9 28.2 3.1e-16 58.9 19.6 2.8 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF2428 PF10350.4 CCF39443.1 - 1.6e-62 210.8 0.1 4.5e-62 209.3 0.0 1.8 2 0 0 2 2 2 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.17 CCF39443.1 - 5.6e-07 29.1 2.4 0.034 14.2 0.0 4.9 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.1 CCF39443.1 - 0.00022 21.4 1.9 0.99 9.7 0.1 3.6 3 0 0 3 3 3 2 HEAT repeats Arm PF00514.18 CCF39443.1 - 0.12 12.2 0.3 1.5 8.7 0.0 2.9 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat HATPase_c PF02518.21 CCF39444.1 - 1.2e-28 99.0 0.2 4.3e-28 97.2 0.1 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 CCF39444.1 - 3.4e-28 97.8 0.4 5.8e-28 97.1 0.3 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.20 CCF39444.1 - 1.2e-12 47.6 0.0 2.4e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.20 CCF39444.1 - 0.00018 21.6 0.0 0.074 13.2 0.0 2.6 2 0 0 2 2 2 2 HAMP domain Methyltransf_23 PF13489.1 CCF39446.1 - 6.3e-10 39.0 0.0 8.5e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF39446.1 - 1.1e-05 25.8 0.0 2.6e-05 24.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF39446.1 - 1.4e-05 25.4 0.0 3.1e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF39446.1 - 4.4e-05 23.1 0.0 7.2e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF39446.1 - 0.00051 19.2 0.0 0.00092 18.3 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 CCF39446.1 - 0.029 14.9 0.0 0.066 13.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_8 PF05148.10 CCF39446.1 - 0.11 12.0 0.0 0.19 11.3 0.0 1.5 1 1 0 1 1 1 0 Hypothetical methyltransferase WH2 PF02205.15 CCF39448.1 - 1.1e-09 37.5 4.1 2e-08 33.5 0.5 3.0 3 0 0 3 3 3 2 WH2 motif Condensation PF00668.15 CCF39449.1 - 7.8e-09 34.7 0.0 1.1e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Condensation domain HxxPF_rpt PF13745.1 CCF39449.1 - 0.00063 20.0 0.0 0.00094 19.4 0.0 1.3 1 0 0 1 1 1 1 HxxPF-repeated domain Zn_clus PF00172.13 CCF39450.1 - 1.9e-08 34.0 7.2 3.5e-08 33.2 5.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_3 PF00933.16 CCF39452.1 - 1.8e-78 263.5 0.0 2.6e-78 263.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 CCF39452.1 - 7e-61 205.6 0.0 1.7e-60 204.3 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 CCF39452.1 - 1.6e-24 85.6 0.5 3.5e-24 84.5 0.3 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.7 CCF39452.1 - 6.6e-06 25.8 0.0 1.4e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 PA14 domain DUF3302 PF11742.3 CCF39454.1 - 0.12 12.2 0.5 0.14 12.0 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3302) CoaE PF01121.15 CCF39455.1 - 1.7e-42 144.8 0.0 7.3e-42 142.8 0.0 1.8 1 1 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.1 CCF39455.1 - 0.012 15.8 0.2 0.49 10.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 CCF39455.1 - 0.015 16.1 0.0 0.045 14.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain Lipase_3 PF01764.20 CCF39456.1 - 2.9e-06 26.9 0.0 6e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) UPF0227 PF05728.7 CCF39456.1 - 0.0011 18.7 0.0 0.0017 18.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Abhydrolase_5 PF12695.2 CCF39456.1 - 0.04 13.6 0.1 0.11 12.2 0.1 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase family YL1 PF05764.8 CCF39457.1 - 5.5e-60 202.9 24.5 5.5e-60 202.9 17.0 2.2 2 0 0 2 2 2 1 YL1 nuclear protein DUF2849 PF11011.3 CCF39457.1 - 0.11 12.8 0.1 0.11 12.8 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2849) SDA1 PF05285.7 CCF39457.1 - 0.24 10.6 34.8 0.05 12.8 16.2 2.2 2 0 0 2 2 2 0 SDA1 Sugar_tr PF00083.19 CCF39458.1 - 1.5e-70 238.0 13.8 2e-70 237.6 9.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF39458.1 - 3.2e-34 118.2 20.9 4e-34 117.8 14.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF39458.1 - 5.4e-06 24.8 2.2 5.4e-06 24.8 1.5 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.1 CCF39458.1 - 7.8e-06 24.5 2.1 7.8e-06 24.5 1.5 2.9 2 1 1 3 3 3 2 MFS/sugar transport protein RseC_MucC PF04246.7 CCF39458.1 - 0.17 11.4 0.9 0.52 9.8 0.6 1.8 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Glyco_hydro_2_N PF02837.13 CCF39459.1 - 4.6e-10 39.3 0.1 6.8e-10 38.7 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Rgp1 PF08737.5 CCF39460.1 - 2.7e-119 398.9 0.0 1.1e-118 396.9 0.0 1.9 2 0 0 2 2 2 1 Rgp1 Arrestin_N PF00339.24 CCF39460.1 - 0.0031 17.3 0.0 0.009 15.8 0.0 1.7 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain DNA_pol_phi PF04931.8 CCF39462.1 - 7.4e-07 27.3 0.0 1.3e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase phi Mannosyl_trans3 PF11051.3 CCF39463.1 - 2.5e-62 210.7 0.0 1.4e-61 208.2 0.0 1.9 1 1 0 1 1 1 1 Mannosyltransferase putative DIOX_N PF14226.1 CCF39464.1 - 4.4e-27 94.9 0.0 6.8e-27 94.3 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 CCF39464.1 - 1e-18 67.4 0.0 2.7e-18 66.0 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.11 CCF39465.1 - 1e-26 93.5 50.7 9.6e-23 80.4 21.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF39465.1 - 8e-05 21.3 37.9 0.00039 19.1 11.7 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter FAD_binding_3 PF01494.14 CCF39466.1 - 2.1e-20 73.1 0.0 5e-20 71.8 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.1 CCF39466.1 - 5.1e-06 26.3 0.0 3.1e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 CCF39466.1 - 0.00024 21.0 0.4 0.00084 19.3 0.3 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF39466.1 - 0.002 17.1 1.5 0.0024 16.8 0.4 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Trp_halogenase PF04820.9 CCF39466.1 - 0.0024 16.5 0.2 0.17 10.4 0.2 2.2 2 0 0 2 2 2 1 Tryptophan halogenase Lycopene_cycl PF05834.7 CCF39466.1 - 0.0031 16.4 0.0 1.2 7.9 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Pyr_redox PF00070.22 CCF39466.1 - 0.0069 16.7 0.7 0.017 15.5 0.5 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF39466.1 - 0.028 13.5 0.2 0.046 12.7 0.2 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.9 CCF39466.1 - 0.14 11.9 0.6 0.28 11.0 0.4 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF39466.1 - 0.36 9.2 1.0 0.55 8.6 0.7 1.2 1 0 0 1 1 1 0 HI0933-like protein ketoacyl-synt PF00109.21 CCF39467.1 - 5.3e-69 232.5 0.2 1.2e-68 231.3 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 CCF39467.1 - 2.3e-32 111.3 0.0 4.7e-32 110.3 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.16 CCF39467.1 - 9.2e-32 110.6 0.0 1.8e-31 109.6 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Thiolase_N PF00108.18 CCF39467.1 - 2.7e-08 33.1 0.4 6.1e-08 31.9 0.1 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain Reo_sigmaC PF04582.7 CCF39469.1 - 0.00015 21.1 6.5 0.17 10.9 0.2 4.0 1 1 2 4 4 4 2 Reovirus sigma C capsid protein Fib_alpha PF08702.5 CCF39469.1 - 0.0022 18.0 5.6 0.0022 18.0 3.9 5.2 2 2 3 5 5 5 2 Fibrinogen alpha/beta chain family Cep57_CLD PF14073.1 CCF39469.1 - 0.0041 16.9 6.0 0.0041 16.9 4.1 3.9 1 1 2 4 4 4 1 Centrosome localisation domain of Cep57 ATG16 PF08614.6 CCF39469.1 - 0.01 15.6 67.1 0.42 10.4 5.9 5.7 1 1 3 5 5 5 0 Autophagy protein 16 (ATG16) DUF869 PF05911.6 CCF39469.1 - 0.4 8.8 66.1 0.31 9.2 27.1 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF869) AAA_13 PF13166.1 CCF39469.1 - 2 6.7 58.3 0.43 8.9 15.4 4.0 1 1 2 4 4 4 0 AAA domain WEMBL PF05701.6 CCF39469.1 - 2.6 6.4 80.9 0.11 10.8 17.7 3.3 1 1 2 3 3 3 0 Weak chloroplast movement under blue light IncA PF04156.9 CCF39469.1 - 3.1 7.3 87.6 0.11 12.0 13.0 5.6 1 1 2 4 4 4 0 IncA protein GAS PF13851.1 CCF39469.1 - 3.2 6.8 76.7 0.096 11.8 10.5 5.7 1 1 5 6 6 6 0 Growth-arrest specific micro-tubule binding Clathrin PF00637.15 CCF39470.1 - 4.7e-187 613.0 28.6 3.3e-34 117.5 1.3 6.1 6 0 0 6 6 6 6 Region in Clathrin and VPS TPR_14 PF13428.1 CCF39470.1 - 3.9e-06 27.0 1.3 7.3 7.5 0.0 7.3 9 1 0 10 10 10 1 Tetratricopeptide repeat TPR_7 PF13176.1 CCF39470.1 - 1.6e-05 24.3 2.1 5.8 6.9 0.0 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.1 CCF39470.1 - 0.0015 18.4 0.6 0.39 10.6 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 CCF39470.1 - 0.0028 17.9 0.3 19 5.6 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 CCF39470.1 - 0.0042 16.7 0.2 7.4 6.6 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 CCF39470.1 - 0.015 15.1 0.8 0.97 9.5 0.0 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 CCF39470.1 - 0.24 11.0 3.9 0.94 9.1 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 CCF39470.1 - 0.35 10.5 6.2 4 7.1 0.1 5.3 5 0 0 5 5 5 0 TPR repeat OB_NTP_bind PF07717.11 CCF39471.1 - 1.2e-23 83.1 0.0 2.1e-23 82.3 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 CCF39471.1 - 1.8e-20 72.8 0.0 4.6e-20 71.5 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 CCF39471.1 - 8.3e-13 48.0 0.0 1.8e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 CCF39471.1 - 0.00022 21.3 0.1 0.00069 19.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.1 CCF39471.1 - 0.00093 18.8 0.1 0.002 17.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain DEAD PF00270.24 CCF39471.1 - 0.0014 18.1 0.9 0.0066 15.9 0.6 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 CCF39471.1 - 0.0096 14.8 0.2 0.022 13.6 0.0 1.6 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_23 PF13476.1 CCF39471.1 - 0.013 15.8 0.2 0.042 14.1 0.0 1.8 2 1 0 2 2 2 0 AAA domain cobW PF02492.14 CCF39471.1 - 0.059 12.8 0.2 1.1 8.7 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 CCF39471.1 - 0.06 12.8 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.1 CCF39471.1 - 0.1 12.5 2.5 0.12 12.2 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.1 CCF39471.1 - 0.11 11.9 0.2 0.74 9.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 CCF39471.1 - 0.13 12.5 0.6 0.77 10.0 0.1 2.2 2 1 0 2 2 2 0 ABC transporter Zeta_toxin PF06414.7 CCF39471.1 - 0.14 11.2 2.6 0.32 10.0 0.0 2.5 2 1 1 3 3 3 0 Zeta toxin FBPase_2 PF06874.6 CCF39471.1 - 0.24 9.3 1.2 0.82 7.6 0.0 1.9 2 0 0 2 2 2 0 Firmicute fructose-1,6-bisphosphatase CUE PF02845.11 CCF39472.1 - 1.7e-12 46.5 0.0 2.6e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 CUE domain CAP_N PF01213.14 CCF39472.1 - 0.18 11.0 1.8 0.25 10.5 1.2 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF3621 PF12285.3 CCF39472.1 - 0.19 11.8 2.8 0.47 10.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3621) Pex14_N PF04695.8 CCF39472.1 - 1 9.4 5.5 0.1 12.6 1.1 1.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region p47_phox_C PF08944.6 CCF39472.1 - 3.9 7.7 8.6 0.37 11.0 2.8 1.6 2 0 0 2 2 2 0 NADPH oxidase subunit p47Phox, C terminal domain DNA_primase_lrg PF04104.9 CCF39473.1 - 1.4e-66 224.4 0.0 2.1e-66 223.8 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit DUF4617 PF15395.1 CCF39473.1 - 0.19 9.7 0.3 0.25 9.3 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4617) DUF3628 PF12300.3 CCF39474.1 - 1.9 8.4 7.8 2.1 8.3 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3628) Ank_2 PF12796.2 CCF39475.1 - 7.2e-09 35.8 0.0 7.9e-07 29.3 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 CCF39475.1 - 6.5e-07 28.8 0.1 0.045 13.5 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 CCF39475.1 - 0.00022 21.1 0.0 5.9 7.4 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.1 CCF39475.1 - 0.00071 20.0 0.1 0.024 15.1 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF39475.1 - 0.013 15.7 0.4 11 6.4 0.0 3.2 4 0 0 4 4 4 0 Ankyrin repeats (many copies) Peptidase_M35 PF02102.10 CCF39476.1 - 1.2e-19 70.2 10.9 1.5e-19 69.8 7.6 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.1 CCF39476.1 - 7.6e-09 36.2 0.6 1.2e-08 35.6 0.4 1.3 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase HRXXH PF13933.1 CCF39476.1 - 0.0019 17.6 1.8 0.0024 17.3 0.2 1.7 2 0 0 2 2 2 1 Putative peptidase family Inhibitor_I67 PF11405.3 CCF39476.1 - 2.4 8.2 6.9 0.33 11.0 1.4 2.0 2 0 0 2 2 2 0 Bromelain inhibitor VI DUF3586 PF12131.3 CCF39477.1 - 0.016 15.1 0.9 0.023 14.7 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3586) FLYWCH PF04500.11 CCF39477.1 - 0.051 13.4 0.2 0.1 12.5 0.1 1.5 1 0 0 1 1 1 0 FLYWCH zinc finger domain TFIIA PF03153.8 CCF39479.1 - 0.0018 18.2 7.1 0.0035 17.3 4.9 1.5 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit BUD22 PF09073.5 CCF39479.1 - 0.79 8.7 20.8 0.0076 15.3 8.8 1.7 2 0 0 2 2 2 0 BUD22 DUF2457 PF10446.4 CCF39479.1 - 1.3 7.6 22.9 2.5 6.7 15.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Arm PF00514.18 CCF39479.1 - 1.4 8.8 6.1 2.4 8.1 0.2 4.0 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Nop14 PF04147.7 CCF39479.1 - 2.1 6.1 18.7 4.6 5.0 13.0 1.5 1 0 0 1 1 1 0 Nop14-like family Daxx PF03344.10 CCF39479.1 - 3.9 5.8 14.0 6.6 5.0 9.7 1.3 1 0 0 1 1 1 0 Daxx Family SDA1 PF05285.7 CCF39479.1 - 4 6.6 16.1 6.5 5.9 11.2 1.3 1 0 0 1 1 1 0 SDA1 Astro_capsid PF03115.9 CCF39479.1 - 4 5.5 5.5 6.3 4.9 3.8 1.2 1 0 0 1 1 1 0 Astrovirus capsid protein precursor DnaJ PF00226.26 CCF39480.1 - 4.6e-13 48.6 0.7 4.6e-13 48.6 0.5 2.8 3 0 0 3 3 3 1 DnaJ domain DUF3512 PF12024.3 CCF39480.1 - 0.051 12.8 5.8 0.047 12.9 1.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3512) DEAD PF00270.24 CCF39481.1 - 2.7e-12 46.5 0.0 3.5e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Glyco_transf_20 PF00982.16 CCF39482.1 - 6.8e-165 549.1 0.0 9.6e-165 548.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 CCF39482.1 - 4.2e-46 156.7 0.0 7.3e-46 155.9 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase Hydrolase_3 PF08282.7 CCF39482.1 - 0.00024 20.7 0.0 0.0059 16.2 0.0 2.4 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase DUF718 PF05336.8 CCF39482.1 - 0.051 13.3 0.5 6.3 6.6 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF718) Glyco_transf_5 PF08323.6 CCF39482.1 - 0.07 12.6 0.3 0.14 11.6 0.2 1.4 1 0 0 1 1 1 0 Starch synthase catalytic domain PNP_UDP_1 PF01048.15 CCF39483.1 - 2.8e-38 131.1 0.4 3.4e-38 130.9 0.3 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily tRNA-synt_1b PF00579.20 CCF39484.1 - 1.1e-57 195.3 0.0 1.4e-57 195.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Atx10homo_assoc PF09759.4 CCF39485.1 - 2e-11 43.4 0.0 5.9e-11 42.0 0.0 1.7 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain Clr5 PF14420.1 CCF39486.1 - 5.2e-20 71.0 3.0 5.2e-20 71.0 2.1 1.8 2 0 0 2 2 2 1 Clr5 domain PH PF00169.24 CCF39487.1 - 0.00015 21.9 0.0 0.00029 21.0 0.0 1.5 1 0 0 1 1 1 1 PH domain eRF1_3 PF03465.10 CCF39487.1 - 0.083 13.1 0.1 0.38 11.0 0.0 2.1 2 0 0 2 2 2 0 eRF1 domain 3 Dioxygenase_C PF00775.16 CCF39489.1 - 7.9e-56 188.2 0.0 1.3e-55 187.5 0.0 1.3 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.9 CCF39489.1 - 1.5e-15 56.9 0.0 1e-14 54.2 0.0 2.2 2 0 0 2 2 2 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.1 CCF39489.1 - 0.0016 18.4 0.0 0.0039 17.2 0.0 1.6 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain DUF824 PF05688.6 CCF39489.1 - 0.021 14.4 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF824) Big_1 PF02369.11 CCF39489.1 - 0.044 13.7 0.0 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) DUF4480 PF13715.1 CCF39489.1 - 0.1 12.6 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4480) AP_endonuc_2 PF01261.19 CCF39490.1 - 4e-30 104.7 0.0 5.8e-30 104.1 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Inositol_P PF00459.20 CCF39491.1 - 7.4e-78 261.5 0.0 8.2e-78 261.4 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Fe-ADH PF00465.14 CCF39492.1 - 1.4e-13 50.2 0.0 1.6e-13 50.1 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DUF2703 PF10865.3 CCF39492.1 - 0.15 11.9 0.0 0.2 11.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2703) RNase_H PF00075.19 CCF39493.1 - 7.8e-16 58.6 0.0 1.1e-15 58.1 0.0 1.2 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.1 CCF39493.1 - 0.0046 16.7 0.0 0.31 10.8 0.0 2.2 2 0 0 2 2 2 2 Reverse transcriptase-like Ribosomal_L1 PF00687.16 CCF39494.1 - 1e-51 175.4 0.4 1.2e-51 175.2 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family p450 PF00067.17 CCF39496.1 - 1.3e-47 162.4 0.0 1.7e-47 162.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 AAA_12 PF13087.1 CCF39497.1 - 7.9e-63 211.4 0.0 1.2e-62 210.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 CCF39497.1 - 4e-52 177.1 0.8 6.2e-52 176.5 0.5 1.2 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 CCF39497.1 - 1.2e-06 28.2 0.0 0.019 14.5 0.0 3.2 2 1 1 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.16 CCF39497.1 - 0.028 13.7 0.2 1 8.5 0.4 2.1 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain DUF2205 PF10224.4 CCF39497.1 - 0.11 12.1 0.8 0.28 10.7 0.3 1.9 1 1 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) Atg14 PF10186.4 CCF39497.1 - 1.7 7.4 4.9 2.8 6.8 3.4 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 tRNA-synt_1d PF00750.14 CCF39500.1 - 3.8e-84 282.5 3.3 5.9e-84 281.8 2.3 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 CCF39500.1 - 2.6e-30 104.8 0.1 7.1e-30 103.4 0.1 1.8 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 CCF39500.1 - 0.052 14.0 0.0 0.16 12.5 0.0 1.9 1 0 0 1 1 1 0 Arginyl tRNA synthetase N terminal domain DUF2407_C PF13373.1 CCF39500.1 - 0.072 13.0 0.6 0.31 10.9 0.0 2.1 1 1 1 2 2 2 0 DUF2407 C-terminal domain Metallophos PF00149.23 CCF39502.1 - 3.1e-37 127.9 0.5 6.8e-29 100.6 0.1 2.1 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase TPR_MLP1_2 PF07926.7 CCF39503.1 - 0.7 9.6 5.3 3.1 7.5 1.9 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Pentapeptide_2 PF01469.13 CCF39503.1 - 0.88 9.2 6.1 1.7 8.3 4.2 1.3 1 0 0 1 1 1 0 Pentapeptide repeats (8 copies) AFG1_ATPase PF03969.11 CCF39504.1 - 9.7e-33 113.4 0.0 1.4e-32 112.8 0.0 1.3 1 0 0 1 1 1 1 AFG1-like ATPase AAA_16 PF13191.1 CCF39504.1 - 0.00083 19.3 0.0 0.0047 16.9 0.0 2.1 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 CCF39504.1 - 0.0026 17.9 0.0 0.021 14.9 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 CCF39504.1 - 0.011 15.4 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.17 CCF39504.1 - 0.023 14.8 0.0 0.05 13.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.7 CCF39504.1 - 0.042 13.5 0.0 0.08 12.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.1 CCF39504.1 - 0.06 13.2 0.0 0.095 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Glyco_hydro_92 PF07971.7 CCF39505.1 - 5.2e-131 437.7 0.3 7.3e-131 437.2 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Acetyltransf_1 PF00583.19 CCF39505.1 - 0.0094 15.9 0.1 0.024 14.6 0.1 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Flavoprotein PF02441.14 CCF39506.1 - 3.6e-16 59.0 0.1 6.4e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 Flavoprotein Flavodoxin_2 PF02525.12 CCF39506.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin-like fold SDF PF00375.13 CCF39507.1 - 3.4e-63 213.7 21.1 3.8e-63 213.5 14.6 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family PBP1_TM PF14812.1 CCF39509.1 - 4.7 7.5 7.2 5.6 7.3 5.0 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Rz1 PF06085.6 CCF39512.1 - 0.41 10.0 0.1 0.41 10.0 0.0 2.8 1 1 1 2 2 2 0 Lipoprotein Rz1 precursor Thioredoxin_5 PF13743.1 CCF39513.1 - 0.009 15.5 0.1 0.14 11.7 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin YlaH PF14036.1 CCF39514.1 - 0.02 14.9 6.0 0.02 14.9 4.2 2.2 2 0 0 2 2 2 0 YlaH-like protein Serpentine_r_xa PF03383.10 CCF39514.1 - 0.82 9.4 7.0 0.26 11.0 2.3 2.1 1 1 1 2 2 2 0 Caenorhabditis serpentine receptor-like protein, class xa Fungal_trans_2 PF11951.3 CCF39515.1 - 0.028 13.0 0.0 0.038 12.5 0.0 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain Aldo_ket_red PF00248.16 CCF39516.1 - 1.5e-52 178.2 0.0 1.8e-52 177.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Frankia_peptide PF14407.1 CCF39516.1 - 0.048 13.4 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. Med21 PF11221.3 CCF39517.1 - 3.2e-36 124.4 3.2 3.7e-36 124.2 2.2 1.0 1 0 0 1 1 1 1 Subunit 21 of Mediator complex Med9 PF07544.8 CCF39517.1 - 0.00014 21.5 8.3 0.001 18.7 0.9 2.5 1 1 1 2 2 2 2 RNA polymerase II transcription mediator complex subunit 9 CENP-Q PF13094.1 CCF39517.1 - 0.014 15.3 3.8 0.016 15.2 2.4 1.3 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit TMCO5 PF14992.1 CCF39517.1 - 0.018 14.1 2.3 0.022 13.9 1.6 1.1 1 0 0 1 1 1 0 TMCO5 family DUF3802 PF12290.3 CCF39517.1 - 0.052 13.8 1.7 0.092 13.0 0.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3802) Spore_III_AB PF09548.5 CCF39517.1 - 0.091 12.4 0.4 0.12 12.1 0.3 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) TMF_DNA_bd PF12329.3 CCF39517.1 - 0.64 9.8 7.5 3.8 7.3 5.2 2.0 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF2034 PF10356.4 CCF39518.1 - 2e-29 102.0 0.0 1.4e-15 56.9 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.7 CCF39518.1 - 1.9e-05 24.4 0.0 3.6e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Restriction endonuclease adh_short PF00106.20 CCF39519.1 - 4.9e-17 62.3 0.1 7.6e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF39519.1 - 1e-10 41.6 0.1 3.6e-10 39.8 0.0 1.8 1 1 1 2 2 2 1 KR domain Epimerase PF01370.16 CCF39519.1 - 0.00021 20.8 0.3 0.00036 20.0 0.2 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 CCF39519.1 - 0.0025 16.7 0.1 0.0052 15.7 0.0 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.15 CCF39519.1 - 0.065 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NUMOD1 PF07453.8 CCF39519.1 - 0.11 12.3 0.1 0.26 11.1 0.1 1.7 1 0 0 1 1 1 0 NUMOD1 domain Patatin PF01734.17 CCF39520.1 - 0.00025 21.0 0.1 0.00027 20.9 0.1 1.1 1 0 0 1 1 1 1 Patatin-like phospholipase Peptidase_M20 PF01546.23 CCF39521.1 - 9.6e-25 87.1 0.1 1.4e-24 86.6 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 CCF39521.1 - 1.8e-22 79.1 0.1 3.5e-22 78.2 0.1 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 CCF39521.1 - 0.0016 18.2 0.0 0.0028 17.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 SLS PF14611.1 CCF39521.1 - 0.075 12.4 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator Methyltransf_3 PF01596.12 CCF39524.1 - 2.6e-34 118.0 0.0 3.5e-34 117.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.1 CCF39524.1 - 3.4e-10 40.6 0.0 8e-10 39.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.14 CCF39524.1 - 3.9e-10 39.6 0.0 5.1e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 CCF39524.1 - 1.8e-08 34.0 0.0 2.5e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF39524.1 - 5.2e-06 26.4 0.0 1e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF39524.1 - 1.6e-05 25.3 0.0 2.6e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF39524.1 - 0.0022 18.3 0.0 0.0035 17.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF39524.1 - 0.026 13.5 0.0 0.036 13.1 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_11 PF08241.7 CCF39524.1 - 0.062 13.7 0.0 0.41 11.1 0.0 2.2 3 0 0 3 3 3 0 Methyltransferase domain MTS PF05175.9 CCF39524.1 - 0.089 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain PGK PF00162.14 CCF39526.1 - 1.5e-151 504.3 1.4 1.7e-151 504.1 1.0 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase FIVAR PF07554.8 CCF39526.1 - 0.011 15.9 3.8 1 9.6 0.0 3.9 4 0 0 4 4 4 0 Uncharacterised Sugar-binding Domain DSS1_SEM1 PF05160.8 CCF39527.1 - 5.5e-25 86.9 11.3 8.7e-25 86.2 7.9 1.3 1 0 0 1 1 1 1 DSS1/SEM1 family MFS_1 PF07690.11 CCF39528.1 - 3.3e-17 62.2 56.0 2.4e-14 52.8 30.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Lactamase_B_2 PF12706.2 CCF39529.1 - 3.1e-24 85.6 0.0 3.8e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 CCF39529.1 - 1.3e-14 54.1 0.0 2e-14 53.6 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Tannase PF07519.6 CCF39530.1 - 6.3e-122 407.6 0.2 7.5e-122 407.4 0.1 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_1 PF00561.15 CCF39530.1 - 0.00055 19.5 0.0 0.00081 19.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF39530.1 - 0.0081 16.0 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family AMP-binding PF00501.23 CCF39531.1 - 2.4e-52 177.7 0.1 3.1e-52 177.3 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.20 CCF39531.1 - 4.4e-10 39.6 0.0 1.4e-09 38.0 0.0 1.8 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.1 CCF39531.1 - 0.00078 20.3 0.0 0.0023 18.8 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain MFS_1 PF07690.11 CCF39532.1 - 1.3e-28 99.7 26.4 5e-28 97.8 18.7 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily 7TM_GPCR_Sra PF02117.11 CCF39532.1 - 0.13 10.8 0.1 0.21 10.1 0.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sra TPR_1 PF00515.23 CCF39533.1 - 9.1e-08 31.3 2.4 1.4e-05 24.4 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 CCF39533.1 - 1.3e-07 31.1 2.1 5.1e-07 29.2 0.1 2.9 3 0 0 3 3 3 1 TPR repeat TPR_2 PF07719.12 CCF39533.1 - 7.7e-05 22.3 0.2 7.7e-05 22.3 0.2 4.9 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.1 CCF39533.1 - 0.00013 21.5 3.2 0.055 13.2 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 CCF39533.1 - 0.00052 19.8 4.0 0.24 11.3 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 CCF39533.1 - 0.017 14.8 0.5 0.57 10.0 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 CCF39533.1 - 0.18 12.5 0.1 0.18 12.5 0.0 5.4 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.1 CCF39533.1 - 0.4 11.4 15.7 2.3 8.9 0.0 5.6 5 2 0 5 5 5 0 Tetratricopeptide repeat NOA36 PF06524.7 CCF39535.1 - 0.71 9.0 7.6 0.78 8.9 5.2 1.1 1 0 0 1 1 1 0 NOA36 protein Sod_Cu PF00080.15 CCF39536.1 - 1.6e-15 57.4 0.1 2.1e-15 57.1 0.1 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) FAD_binding_1 PF00667.15 CCF39537.1 - 5.4e-41 140.4 0.0 1e-40 139.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 CCF39537.1 - 4.9e-31 107.6 0.4 2.1e-30 105.6 0.0 2.2 3 0 0 3 3 3 1 Flavodoxin NAD_binding_1 PF00175.16 CCF39537.1 - 3e-20 72.8 0.0 9.9e-20 71.1 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain CTC1 PF15489.1 CCF39537.1 - 0.26 8.5 0.0 0.38 8.0 0.0 1.1 1 0 0 1 1 1 0 CST, telomere maintenance, complex subunit CTC1 MFS_1 PF07690.11 CCF39539.1 - 9.9e-36 123.1 69.0 3.4e-35 121.4 33.7 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3272 PF11676.3 CCF39539.1 - 0.13 12.3 1.1 0.44 10.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3272) MFS_2 PF13347.1 CCF39539.1 - 8.3 4.6 50.4 0.54 8.5 8.9 3.1 1 1 1 2 2 2 0 MFS/sugar transport protein Hist_deacetyl PF00850.14 CCF39543.1 - 1.6e-78 264.1 0.1 2.6e-78 263.4 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain JAB PF01398.16 CCF39544.1 - 5.1e-35 119.6 0.0 9.5e-35 118.7 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.1 CCF39544.1 - 1.7e-27 95.8 1.8 3.9e-27 94.6 1.2 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.1 CCF39544.1 - 1.6e-08 34.0 0.0 2.6e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain BLVR PF06375.6 CCF39545.1 - 0.082 12.7 4.9 0.1 12.4 3.4 1.1 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) Glyco_hydro_10 PF00331.15 CCF39546.1 - 3.7e-55 187.1 0.0 4.1e-55 187.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 MFS_1 PF07690.11 CCF39547.1 - 8.2e-32 110.2 28.2 8.2e-32 110.2 19.6 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily OSTbeta PF15048.1 CCF39547.1 - 0.12 12.4 0.1 0.3 11.1 0.0 1.7 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein FA_desaturase PF00487.19 CCF39547.1 - 0.21 10.9 0.1 0.21 10.9 0.0 3.6 2 2 1 4 4 4 0 Fatty acid desaturase DUF2207 PF09972.4 CCF39547.1 - 3.8 6.0 9.2 2.1 6.8 0.5 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) TRAP-gamma PF07074.7 CCF39548.1 - 0.014 14.9 0.3 0.014 14.9 0.2 2.8 2 1 0 2 2 2 0 Translocon-associated protein, gamma subunit (TRAP-gamma) Ribosomal_L7Ae PF01248.21 CCF39549.1 - 4.7e-08 32.4 0.0 5.9e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Glyco_hydro_16 PF00722.16 CCF39550.1 - 9.4e-12 44.5 0.6 1.4e-11 44.0 0.4 1.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.10 CCF39550.1 - 0.013 13.6 0.2 0.037 12.1 0.1 1.6 1 1 1 2 2 2 0 Beta-glucan synthesis-associated protein (SKN1) 2-oxoacid_dh PF00198.18 CCF39551.1 - 7.8e-79 264.1 0.0 1.1e-78 263.7 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 CCF39551.1 - 6.9e-19 67.2 4.3 1.2e-18 66.4 3.0 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme RnfC_N PF13375.1 CCF39551.1 - 0.0008 19.0 0.9 1.6 8.4 0.1 3.0 1 1 2 3 3 3 2 RnfC Barrel sandwich hybrid domain Biotin_lipoyl_2 PF13533.1 CCF39551.1 - 0.0071 15.9 0.9 0.17 11.5 0.1 2.3 1 1 1 2 2 2 2 Biotin-lipoyl like Tape_meas_lam_C PF09718.5 CCF39551.1 - 0.022 14.6 0.0 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) HlyD_3 PF13437.1 CCF39551.1 - 0.046 14.0 0.5 0.15 12.4 0.4 1.7 1 1 0 1 1 1 0 HlyD family secretion protein Catalase PF00199.14 CCF39553.1 - 6.6e-27 94.1 0.4 9.4e-27 93.6 0.3 1.2 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.7 CCF39553.1 - 1.1e-15 57.2 0.1 2e-15 56.3 0.1 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive DUF4066 PF13278.1 CCF39554.1 - 1.6e-27 95.8 0.0 2.1e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 Putative amidotransferase DJ-1_PfpI PF01965.19 CCF39554.1 - 8.7e-11 41.4 0.1 1.2e-10 40.9 0.1 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family IU_nuc_hydro PF01156.14 CCF39555.1 - 8.1e-25 87.6 0.0 1.6e-24 86.6 0.0 1.5 1 1 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Amidase PF01425.16 CCF39556.1 - 2.3e-34 119.0 1.1 6.2e-33 114.3 0.4 2.1 2 0 0 2 2 2 2 Amidase MFS_1 PF07690.11 CCF39557.1 - 6.5e-22 77.7 18.6 8.1e-22 77.4 12.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily VIT1 PF01988.14 CCF39557.1 - 0.79 9.1 6.1 0.26 10.7 2.0 1.7 1 1 0 1 1 1 0 VIT family TMEM107 PF14995.1 CCF39557.1 - 5.5 7.1 13.3 0.097 12.7 3.4 2.5 2 2 0 2 2 2 0 Transmembrane protein Ank_2 PF12796.2 CCF39558.1 - 1.2e-39 134.5 26.3 3.2e-06 27.3 0.1 11.9 5 2 8 13 13 13 11 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF39558.1 - 2.9e-14 53.1 14.4 2.7 8.6 0.2 13.2 13 3 1 14 14 14 4 Ankyrin repeats (many copies) Ank PF00023.25 CCF39558.1 - 1.1e-13 50.2 35.8 0.15 11.9 0.0 15.6 17 1 0 17 17 17 6 Ankyrin repeat Ank_5 PF13857.1 CCF39558.1 - 3.8e-08 33.3 12.5 0.27 11.5 0.0 11.6 12 1 1 13 13 13 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF39558.1 - 7.6e-08 31.8 27.0 0.8 10.1 0.0 14.1 19 0 0 19 19 19 3 Ankyrin repeat Gly-zipper_Omp PF13488.1 CCF39559.1 - 0.00013 21.5 2.0 0.00021 20.8 1.4 1.3 1 0 0 1 1 1 1 Glycine zipper Gly-zipper_YMGG PF13441.1 CCF39559.1 - 0.0032 16.9 2.7 0.0054 16.2 1.9 1.3 1 0 0 1 1 1 1 YMGG-like Gly-zipper Rick_17kDa_Anti PF05433.10 CCF39559.1 - 0.0038 16.8 2.6 0.0065 16.1 1.8 1.3 1 0 0 1 1 1 1 Glycine zipper 2TM domain Gly-zipper_OmpA PF13436.1 CCF39559.1 - 0.0062 16.1 1.9 0.014 15.0 1.3 1.5 1 0 0 1 1 1 1 Glycine-zipper containing OmpA-like membrane domain SNF PF00209.13 CCF39560.1 - 1.2e-40 139.4 11.5 5.9e-39 133.9 8.0 2.0 1 1 0 1 1 1 1 Sodium:neurotransmitter symporter family DUF3357 PF11837.3 CCF39561.1 - 0.084 12.7 0.1 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) DUF3328 PF11807.3 CCF39561.1 - 0.27 10.8 5.4 1 8.9 3.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3328) Aa_trans PF01490.13 CCF39563.1 - 9.5e-26 90.2 24.1 9.5e-26 90.2 16.7 1.8 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 CCF39563.1 - 1.8e-07 30.3 11.6 1.8e-07 30.3 8.0 2.5 2 1 0 3 3 3 1 Tryptophan/tyrosine permease family An_peroxidase PF03098.10 CCF39565.1 - 9.4e-85 284.9 0.0 1.9e-82 277.3 0.0 2.1 1 1 0 1 1 1 1 Animal haem peroxidase p450 PF00067.17 CCF39565.1 - 1.9e-08 33.3 0.0 4.4e-07 28.7 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 DUF2235 PF09994.4 CCF39566.1 - 1e-71 241.5 5.6 1.2e-69 234.7 3.9 2.9 1 1 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Tautomerase_3 PF14832.1 CCF39567.1 - 4e-10 39.8 0.0 9.7e-10 38.5 0.0 1.6 1 1 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme p450 PF00067.17 CCF39568.1 - 3.4e-40 137.9 0.0 4.9e-40 137.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Sugar_tr PF00083.19 CCF39569.1 - 4.2e-110 368.4 26.4 4.8e-110 368.2 18.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF39569.1 - 1.1e-19 70.3 26.6 1.1e-19 70.3 18.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Lactonase PF10282.4 CCF39571.1 - 2.2e-06 27.0 0.3 0.0026 16.9 0.0 3.3 1 1 2 3 3 3 3 Lactonase, 7-bladed beta-propeller NHL PF01436.16 CCF39571.1 - 0.072 13.0 0.3 9.1 6.4 0.0 3.1 3 0 0 3 3 3 0 NHL repeat DUF1815 PF08844.5 CCF39571.1 - 0.12 11.9 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1815) AA_permease PF00324.16 CCF39572.1 - 3.3e-98 329.1 37.3 4e-98 328.8 25.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF39572.1 - 8.4e-22 77.2 40.1 1.1e-21 76.8 27.8 1.0 1 0 0 1 1 1 1 Amino acid permease Fungal_trans PF04082.13 CCF39573.1 - 0.077 11.8 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain GST_C PF00043.20 CCF39574.1 - 0.00044 20.1 0.0 0.00093 19.1 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 CCF39574.1 - 0.0071 16.5 0.1 0.35 11.1 0.0 2.6 2 1 1 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 CCF39574.1 - 0.024 14.6 0.1 0.078 12.9 0.0 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 CCF39574.1 - 0.082 12.8 0.0 0.23 11.3 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain p450 PF00067.17 CCF39575.1 - 4.9e-28 97.8 0.0 6.4e-28 97.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.20 CCF39576.1 - 0.024 14.5 0.0 6.4 6.6 0.0 2.2 2 0 0 2 2 2 0 short chain dehydrogenase KR PF08659.5 CCF39576.1 - 0.14 11.7 0.2 13 5.4 0.0 2.2 2 0 0 2 2 2 0 KR domain adh_short PF00106.20 CCF39577.1 - 4e-07 30.1 0.4 5.3e-07 29.7 0.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.1 CCF39577.1 - 1.5e-06 28.3 2.4 3e-06 27.3 1.7 1.7 1 1 0 1 1 1 1 NADH(P)-binding adh_short_C2 PF13561.1 CCF39577.1 - 5.5e-06 26.3 0.1 0.00022 21.0 0.0 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF39577.1 - 0.00019 21.1 1.0 0.00032 20.3 0.7 1.3 1 0 0 1 1 1 1 KR domain F420_oxidored PF03807.12 CCF39577.1 - 0.0015 18.8 0.5 0.0033 17.7 0.3 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NmrA PF05368.8 CCF39577.1 - 0.002 17.4 3.7 0.0026 17.0 2.6 1.5 1 1 0 1 1 1 1 NmrA-like family PALP PF00291.20 CCF39577.1 - 0.005 16.1 0.9 0.0071 15.6 0.6 1.3 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Semialdhyde_dh PF01118.19 CCF39577.1 - 0.0051 17.1 0.6 0.013 15.8 0.4 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Eno-Rase_NADH_b PF12242.3 CCF39577.1 - 0.0052 16.5 0.7 0.038 13.7 0.4 2.2 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase AlaDh_PNT_C PF01262.16 CCF39577.1 - 0.03 13.8 0.7 0.051 13.1 0.5 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Epimerase PF01370.16 CCF39577.1 - 0.039 13.3 0.2 0.05 13.0 0.2 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.21 CCF39577.1 - 0.18 11.3 1.7 0.35 10.4 1.2 1.5 1 1 0 1 1 1 0 Zinc-binding dehydrogenase 3HCDH_N PF02737.13 CCF39577.1 - 0.34 10.5 3.1 0.32 10.6 1.2 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ketoacyl-synt_C PF02801.17 CCF39578.1 - 2.9e-30 104.5 0.7 1.2e-29 102.5 0.4 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.16 CCF39578.1 - 4.2e-29 101.9 0.5 7.5e-20 71.4 0.8 2.2 1 1 1 2 2 2 2 Acyl transferase domain Chlorosome_CsmC PF11098.3 CCF39580.1 - 0.011 15.4 0.2 0.022 14.4 0.2 1.4 1 0 0 1 1 1 0 Chlorosome envelope protein C TraI_2 PF07514.6 CCF39581.1 - 0.063 12.0 0.3 0.067 11.9 0.2 1.0 1 0 0 1 1 1 0 Putative helicase Amino_oxidase PF01593.19 CCF39582.1 - 3.1e-30 105.6 0.1 1.5e-22 80.2 0.1 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 CCF39582.1 - 9.7e-07 28.7 0.0 2.5e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_4 PF07993.7 CCF39583.1 - 1.6e-24 86.2 0.0 1.9e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.16 CCF39583.1 - 3e-06 26.8 0.0 3.9e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF39583.1 - 0.0085 16.1 0.0 0.012 15.5 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding SIR2 PF02146.12 CCF39584.1 - 3.5e-61 206.0 0.0 5.4e-61 205.4 0.0 1.3 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.8 CCF39584.1 - 7e-05 22.4 0.0 0.00013 21.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.17 CCF39584.1 - 0.00021 21.0 0.1 0.37 10.5 0.0 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Mito_carr PF00153.22 CCF39585.1 - 2e-14 53.0 0.0 2.5e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial carrier protein F-box-like PF12937.2 CCF39586.1 - 0.00015 21.4 0.3 0.00026 20.6 0.2 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF39586.1 - 0.0087 15.6 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 F-box domain zf-RING_2 PF13639.1 CCF39587.1 - 3.9 7.3 14.1 3 7.7 6.6 3.1 2 1 0 2 2 2 0 Ring finger domain DUF2589 PF11655.3 CCF39588.1 - 0.0046 17.1 0.5 0.015 15.4 0.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2589) Prefoldin_3 PF13758.1 CCF39588.1 - 5.5 6.8 11.1 4.2 7.2 3.8 3.0 2 1 0 2 2 2 0 Prefoldin subunit DEPP PF15343.1 CCF39589.1 - 0.0041 16.7 0.3 0.0057 16.2 0.2 1.2 1 0 0 1 1 1 1 Decidual protein induced by progesterone family VPS9 PF02204.13 CCF39590.1 - 1.6e-24 85.9 0.0 2.6e-24 85.2 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Methyltransf_23 PF13489.1 CCF39591.1 - 1.1e-20 74.0 0.0 1.7e-20 73.3 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF39591.1 - 7.3e-10 39.4 0.0 1.7e-08 34.9 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF39591.1 - 1.2e-09 37.9 0.0 1.6e-08 34.2 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF39591.1 - 6.6e-09 36.1 0.0 1.3e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF39591.1 - 7.8e-08 32.7 0.0 4.7e-07 30.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF39591.1 - 7.2e-06 26.2 0.0 1.9e-05 24.9 0.0 1.7 2 1 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 CCF39591.1 - 0.0052 16.7 0.0 0.0074 16.2 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.9 CCF39591.1 - 0.04 13.3 0.0 0.16 11.3 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.15 CCF39591.1 - 0.087 11.8 0.0 0.2 10.7 0.0 1.4 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_26 PF13659.1 CCF39591.1 - 0.098 12.6 0.0 0.55 10.2 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Gamma-thionin PF00304.15 CCF39592.1 - 0.13 12.3 12.8 0.36 10.8 1.7 2.3 2 0 0 2 2 2 0 Gamma-thionin family Colipase-like PF15083.1 CCF39592.1 - 0.4 10.6 6.7 4.4 7.3 0.5 2.1 2 0 0 2 2 2 0 Colipase-like Colipase PF01114.13 CCF39592.1 - 3.7 7.0 17.4 3.4 7.2 4.0 2.3 2 0 0 2 2 2 0 Colipase, N-terminal domain Toxin_11 PF07473.6 CCF39592.1 - 7.8 6.4 16.3 9.4 6.2 3.0 2.4 2 0 0 2 2 2 0 Spasmodic peptide gm9a PepX_C PF08530.5 CCF39593.1 - 0.00073 19.4 0.0 0.00089 19.2 0.0 1.1 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain FAA_hydrolase PF01557.13 CCF39594.1 - 2.2e-46 158.0 0.0 3e-46 157.6 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.6 CCF39594.1 - 4.9e-12 45.7 0.0 3.9e-11 42.9 0.0 2.2 2 0 0 2 2 2 1 Fumarylacetoacetase N-terminal Zn_clus PF00172.13 CCF39596.1 - 0.00064 19.5 12.3 0.0012 18.7 8.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CHZ PF09649.5 CCF39596.1 - 0.039 13.1 0.0 0.039 13.1 0.0 2.3 3 0 0 3 3 3 0 Histone chaperone domain CHZ MFS_1 PF07690.11 CCF39598.1 - 4.9e-32 110.9 44.1 4.9e-32 110.9 30.6 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF39598.1 - 0.021 14.6 10.5 0.64 9.8 3.0 3.5 3 0 0 3 3 3 0 MFS_1 like family Abhydrolase_3 PF07859.8 CCF39599.1 - 1.5e-06 27.9 0.2 8.9e-05 22.1 0.2 2.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF39599.1 - 2.5e-05 24.2 1.0 5.2e-05 23.2 0.7 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF39599.1 - 0.0019 17.9 0.1 0.0046 16.7 0.1 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF39599.1 - 0.043 13.3 0.0 1.9 7.9 0.0 2.2 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF1057 PF06342.7 CCF39599.1 - 0.15 10.8 0.0 0.24 10.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Endosulfine PF04667.12 CCF39600.1 - 1.8e-21 75.9 0.0 2.8e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region UPF0160 PF03690.8 CCF39601.1 - 1.1e-121 406.2 0.0 1.2e-121 406.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Diphthamide_syn PF01866.12 CCF39602.1 - 8.6e-113 376.6 0.0 1e-112 376.3 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Aldose_epim PF01263.15 CCF39603.1 - 1.4e-50 172.1 0.3 1.9e-50 171.7 0.2 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase TPR_11 PF13414.1 CCF39604.1 - 3.1e-24 84.4 10.5 1.9e-10 40.2 0.5 4.5 2 2 1 4 4 4 4 TPR repeat TPR_1 PF00515.23 CCF39604.1 - 1.5e-23 81.3 5.5 7.5e-08 31.6 0.0 6.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.12 CCF39604.1 - 3e-21 73.5 14.5 1e-06 28.1 0.0 6.4 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_14 PF13428.1 CCF39604.1 - 9.2e-18 63.1 13.6 8.2e-06 26.0 0.0 6.3 5 1 2 7 7 6 3 Tetratricopeptide repeat TPR_17 PF13431.1 CCF39604.1 - 1.2e-15 56.2 5.8 0.0022 18.0 0.0 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.1 CCF39604.1 - 3.8e-15 56.0 14.5 6.3e-06 26.7 0.1 4.8 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 CCF39604.1 - 3.1e-14 52.6 3.5 3.2e-07 30.2 0.6 4.5 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.1 CCF39604.1 - 1.9e-13 49.1 3.0 0.0055 16.4 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.1 CCF39604.1 - 4e-12 46.3 13.5 0.00036 20.8 3.3 5.3 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.1 CCF39604.1 - 4.2e-11 41.7 3.3 0.00012 21.6 0.0 5.8 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_9 PF13371.1 CCF39604.1 - 2.7e-08 33.5 2.8 0.016 15.0 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 CCF39604.1 - 4.4e-08 33.0 9.2 0.08 13.4 0.1 6.6 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_20 PF14561.1 CCF39604.1 - 4e-07 30.0 10.1 0.0019 18.2 0.2 4.8 4 1 1 5 5 5 3 Tetratricopeptide repeat Apc3 PF12895.2 CCF39604.1 - 0.00012 22.1 4.2 0.32 11.1 0.4 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF484 PF04340.7 CCF39604.1 - 0.0016 17.9 0.0 0.0058 16.1 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function, DUF484 TPR_10 PF13374.1 CCF39604.1 - 0.0098 15.7 2.3 0.59 10.1 0.1 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat NatB_MDM20 PF09797.4 CCF39604.1 - 0.04 12.6 0.0 0.086 11.5 0.0 1.5 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_15 PF13429.1 CCF39604.1 - 0.069 12.1 8.6 0.82 8.6 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat RPA PF10134.4 CCF39604.1 - 0.14 11.4 0.4 0.25 10.5 0.3 1.3 1 0 0 1 1 1 0 Replication initiator protein A Xpo1 PF08389.7 CCF39605.1 - 4.4e-10 39.6 0.0 6.2e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Exportin 1-like protein IBN_N PF03810.14 CCF39605.1 - 0.00012 21.9 0.0 0.00018 21.3 0.0 1.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain adh_short PF00106.20 CCF39606.1 - 5.1e-10 39.5 1.0 1.2e-09 38.3 0.1 1.9 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 CCF39606.1 - 0.002 17.8 0.2 0.046 13.3 0.0 2.2 2 0 0 2 2 2 1 KR domain Pkinase PF00069.20 CCF39607.1 - 4e-13 49.1 0.0 1.7e-12 47.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF39607.1 - 2e-07 30.3 0.0 5.8e-07 28.8 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF39607.1 - 0.0067 15.4 0.1 0.046 12.6 0.0 2.2 2 1 0 2 2 2 1 Kinase-like HEAT_2 PF13646.1 CCF39607.1 - 0.03 14.5 0.2 0.058 13.6 0.1 1.4 1 0 0 1 1 1 0 HEAT repeats ORC4_C PF14629.1 CCF39608.1 - 2e-57 193.8 0.0 3e-57 193.2 0.0 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.1 CCF39608.1 - 3.5e-16 59.7 0.2 2.1e-15 57.1 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain PHD PF00628.24 CCF39608.1 - 6.7e-11 41.7 7.6 1.3e-10 40.7 5.2 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.1 CCF39608.1 - 1.9e-09 36.6 4.7 3.8e-09 35.7 3.2 1.5 1 0 0 1 1 1 1 PHD-finger AAA PF00004.24 CCF39608.1 - 1.4e-08 34.9 0.0 3.3e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CCF39608.1 - 1.1e-07 32.0 0.0 3.3e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 CCF39608.1 - 6.1e-07 29.2 0.1 3e-06 26.9 0.0 2.0 1 1 0 1 1 1 1 NACHT domain KAP_NTPase PF07693.9 CCF39608.1 - 6.2e-06 25.4 0.0 1.3e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 KAP family P-loop domain Arch_ATPase PF01637.13 CCF39608.1 - 3.7e-05 23.5 0.0 8.8e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 Archaeal ATPase AAA_14 PF13173.1 CCF39608.1 - 0.00041 20.2 0.1 0.0012 18.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain ORC2 PF04084.9 CCF39608.1 - 0.00049 19.0 0.3 1.1 8.0 0.0 2.8 3 0 0 3 3 3 2 Origin recognition complex subunit 2 ATP-synt_ab PF00006.20 CCF39608.1 - 0.00057 19.4 0.1 0.0017 17.9 0.0 1.8 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ABC_tran PF00005.22 CCF39608.1 - 0.00067 19.9 0.1 0.0027 18.0 0.0 2.1 2 1 0 2 2 1 1 ABC transporter NB-ARC PF00931.17 CCF39608.1 - 0.0012 17.7 0.0 0.0024 16.8 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain DUF815 PF05673.8 CCF39608.1 - 0.0018 17.2 0.1 0.0033 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) C1_1 PF00130.17 CCF39608.1 - 0.0021 17.7 0.6 0.0021 17.7 0.4 1.7 2 0 0 2 2 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SMC_N PF02463.14 CCF39608.1 - 0.0022 17.2 0.0 0.0073 15.5 0.0 1.8 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 CCF39608.1 - 0.0059 16.1 0.0 0.014 14.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Miro PF08477.8 CCF39608.1 - 0.0071 16.8 0.0 0.037 14.5 0.0 2.4 1 1 0 1 1 1 1 Miro-like protein FtsK_SpoIIIE PF01580.13 CCF39608.1 - 0.0084 15.5 0.2 0.051 13.0 0.0 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_10 PF12846.2 CCF39608.1 - 0.0099 15.3 0.2 1.6 8.0 0.0 2.3 2 0 0 2 2 2 1 AAA-like domain FYVE_2 PF02318.11 CCF39608.1 - 0.01 15.7 2.0 0.023 14.6 1.4 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger Prok-RING_1 PF14446.1 CCF39608.1 - 0.012 15.2 3.7 0.031 13.9 2.5 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Bac_DnaA PF00308.13 CCF39608.1 - 0.017 14.8 0.0 1.5 8.4 0.0 2.2 2 0 0 2 2 2 0 Bacterial dnaA protein MobB PF03205.9 CCF39608.1 - 0.022 14.4 0.0 0.081 12.6 0.0 1.9 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.1 CCF39608.1 - 0.023 14.1 0.0 0.042 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 CCF39608.1 - 0.024 14.1 0.1 0.042 13.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.17 CCF39608.1 - 0.029 14.5 0.0 0.26 11.4 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.1 CCF39608.1 - 0.033 14.1 0.1 0.11 12.4 0.0 2.0 2 0 0 2 2 1 0 AAA domain AAA_17 PF13207.1 CCF39608.1 - 0.041 14.6 0.0 0.13 13.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 CCF39608.1 - 0.066 12.6 0.1 0.22 10.9 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.13 CCF39608.1 - 0.075 12.5 0.8 0.4 10.1 0.0 2.5 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase PduV-EutP PF10662.4 CCF39608.1 - 0.079 12.4 1.0 0.2 11.1 0.1 2.3 2 1 0 2 2 1 0 Ethanolamine utilisation - propanediol utilisation AAA_15 PF13175.1 CCF39608.1 - 0.098 11.6 0.0 0.2 10.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain zf-PHD-like PF15446.1 CCF39608.1 - 3.5 6.8 13.0 0.14 11.4 4.1 2.2 2 1 0 2 2 1 0 PHD/FYVE-zinc-finger like domain Glyco_hydro_16 PF00722.16 CCF39609.1 - 1e-08 34.6 0.9 1.8e-08 33.9 0.2 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 GP41 PF00517.12 CCF39609.1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Retroviral envelope protein Frag1 PF10277.4 CCF39610.1 - 1.8e-24 86.4 6.3 1.8e-24 86.4 4.4 3.0 3 0 0 3 3 3 2 Frag1/DRAM/Sfk1 family PsiA PF06952.6 CCF39610.1 - 0.68 8.9 5.1 0.24 10.4 1.0 2.1 3 0 0 3 3 3 0 PsiA protein UCH PF00443.24 CCF39611.1 - 1.2e-40 139.3 0.0 1.8e-40 138.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.1 CCF39611.1 - 4e-21 74.1 1.6 1.2e-09 37.4 0.0 3.0 3 0 0 3 3 3 2 A repeated domain in UCH-protein UCH_1 PF13423.1 CCF39611.1 - 5.2e-10 39.2 0.3 0.00022 20.8 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DELLA PF12041.3 CCF39611.1 - 0.063 12.9 0.5 0.25 11.0 0.0 2.2 2 0 0 2 2 2 0 Transcriptional regulator DELLA protein N terminal Tim17 PF02466.14 CCF39612.1 - 4.1e-10 39.8 9.6 6.3e-10 39.1 6.7 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family ECH PF00378.15 CCF39613.1 - 1.5e-10 40.6 0.0 1.7e-10 40.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family NAD_binding_8 PF13450.1 CCF39614.1 - 1.9e-12 47.0 0.2 5.8e-12 45.4 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF39614.1 - 1.9e-10 40.1 0.0 1.5e-08 33.9 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF39614.1 - 9.8e-06 25.5 0.0 0.0062 16.4 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF39614.1 - 1.3e-05 25.4 0.0 0.2 12.1 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF39614.1 - 0.00013 20.9 0.0 0.00022 20.2 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.1 CCF39614.1 - 0.00023 21.3 0.1 0.0011 19.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF39614.1 - 0.00045 18.7 0.0 0.023 13.2 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_9 PF13454.1 CCF39614.1 - 0.00058 19.6 0.0 0.0037 17.0 0.0 2.3 3 0 0 3 3 3 1 FAD-NAD(P)-binding Thi4 PF01946.12 CCF39614.1 - 0.0024 16.9 0.0 0.0046 16.0 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.7 CCF39614.1 - 0.0091 14.9 0.0 0.014 14.3 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Shikimate_DH PF01488.15 CCF39614.1 - 0.017 15.2 0.0 0.03 14.4 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.14 CCF39614.1 - 0.056 12.4 0.0 0.16 10.9 0.0 1.7 2 0 0 2 2 2 0 FAD binding domain NAD_binding_7 PF13241.1 CCF39614.1 - 0.12 12.6 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Sugar_tr PF00083.19 CCF39617.1 - 1e-91 307.7 24.7 1.3e-91 307.4 17.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF39617.1 - 1.9e-18 66.3 54.1 6.5e-16 57.9 19.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TAF PF02969.12 CCF39617.1 - 0.086 12.8 0.1 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) WD40 PF00400.27 CCF39618.1 - 2e-16 59.1 5.6 0.00027 20.6 0.0 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat PQQ_3 PF13570.1 CCF39618.1 - 0.061 13.6 0.5 4.7 7.6 0.0 3.4 3 0 0 3 3 3 0 PQQ-like domain Nup160 PF11715.3 CCF39618.1 - 0.095 10.8 0.0 2 6.4 0.0 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 DUF1556 PF07590.6 CCF39618.1 - 0.28 11.4 2.3 0.49 10.6 1.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1556) DUF3237 PF11578.3 CCF39619.1 - 7.5e-35 119.4 0.0 8.6e-35 119.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) DUF2264 PF10022.4 CCF39620.1 - 7.4e-14 51.1 0.0 9e-14 50.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) FH2 PF02181.18 CCF39621.1 - 4.3e-84 282.5 4.2 5.8e-84 282.1 2.9 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain DUF4634 PF15465.1 CCF39621.1 - 0.094 12.9 0.0 0.27 11.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4634) HET PF06985.6 CCF39623.1 - 3.7e-27 95.1 0.0 7.6e-27 94.1 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF3659 PF12396.3 CCF39625.1 - 1.7e-131 427.9 57.0 8.6e-23 79.7 0.8 7.6 7 0 0 7 7 7 7 Protein of unknown function (DUF3659) GCV_T_C PF08669.6 CCF39625.1 - 0.038 14.0 3.4 15 5.7 0.0 4.6 4 1 0 4 4 4 0 Glycine cleavage T-protein C-terminal barrel domain Cys_Met_Meta_PP PF01053.15 CCF39627.1 - 3.3e-42 144.1 0.0 4e-42 143.8 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 CCF39627.1 - 0.0014 17.4 0.0 0.0026 16.5 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 CCF39627.1 - 0.02 13.8 0.0 0.041 12.8 0.0 1.4 1 1 0 1 1 1 0 Aminotransferase class I and II VWA_3 PF13768.1 CCF39629.1 - 1.6e-30 105.8 0.0 2.8e-30 105.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT PF08487.5 CCF39629.1 - 4.9e-18 64.9 0.0 9.9e-18 63.9 0.0 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_2 PF13519.1 CCF39629.1 - 2.4e-13 50.5 0.0 5.3e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 CCF39629.1 - 1.2e-05 25.0 0.0 3.4e-05 23.6 0.0 1.7 1 1 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.1 CCF39629.1 - 2.3e-05 23.7 0.1 5.1e-05 22.6 0.1 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_CoxE PF05762.9 CCF39629.1 - 0.008 15.3 0.1 0.028 13.5 0.1 1.8 1 1 0 1 1 1 1 VWA domain containing CoxE-like protein DUF2201 PF09967.4 CCF39629.1 - 0.039 13.9 0.1 0.24 11.4 0.0 2.4 2 1 0 2 2 2 0 VWA-like domain (DUF2201) PIRT PF15099.1 CCF39630.1 - 0.0077 15.4 0.6 0.023 13.8 0.4 1.8 1 0 0 1 1 1 1 Phosphoinositide-interacting protein family E1-E2_ATPase PF00122.15 CCF39632.1 - 2.9e-24 85.3 0.9 4.6e-24 84.7 0.6 1.3 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_N PF00690.21 CCF39632.1 - 4.2e-06 26.1 0.2 1.1e-05 24.8 0.0 1.8 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus DUF2976 PF11190.3 CCF39632.1 - 0.21 11.1 1.4 0.44 10.1 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) DUF4334 PF14232.1 CCF39633.1 - 6.6e-24 83.3 5.8 1.2e-23 82.4 0.9 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4334) GXWXG PF14231.1 CCF39633.1 - 3e-22 78.0 0.1 5.3e-22 77.2 0.1 1.4 1 0 0 1 1 1 1 GXWXG protein FAD_binding_4 PF01565.18 CCF39634.1 - 1.7e-17 63.1 2.4 4.4e-17 61.8 1.7 1.7 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 CCF39634.1 - 2.3e-05 24.1 0.4 8.1e-05 22.4 0.1 2.1 2 0 0 2 2 2 1 Berberine and berberine like DUF1765 PF08578.5 CCF39635.1 - 3.4e-43 146.7 1.6 5.6e-43 146.0 1.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) NUC153 PF08159.7 CCF39636.1 - 8.8e-14 50.8 0.7 8.8e-14 50.8 0.5 3.4 3 1 0 3 3 3 1 NUC153 domain Glyco_transf_41 PF13844.1 CCF39637.1 - 1.4e-83 280.4 0.1 2.7e-51 174.0 0.0 3.3 1 1 1 2 2 2 2 Glycosyl transferase family 41 UAA PF08449.6 CCF39638.1 - 2e-09 36.8 10.8 2.6e-09 36.4 7.5 1.1 1 0 0 1 1 1 1 UAA transporter family adh_short PF00106.20 CCF39639.1 - 1.6e-19 70.4 0.0 2.6e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF39639.1 - 7.5e-10 38.7 0.0 2.5e-09 37.0 0.0 1.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF39639.1 - 1.3e-07 31.3 0.0 2.4e-07 30.4 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF39639.1 - 1.1e-05 24.2 0.1 1.6e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 CCF39639.1 - 6.5e-05 21.9 0.0 8.9e-05 21.5 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 CCF39639.1 - 0.002 18.1 0.0 0.006 16.6 0.0 1.9 1 1 0 1 1 1 1 NADH(P)-binding RmlD_sub_bind PF04321.12 CCF39639.1 - 0.003 16.4 0.0 0.0061 15.4 0.0 1.5 2 0 0 2 2 2 1 RmlD substrate binding domain NmrA PF05368.8 CCF39639.1 - 0.079 12.1 0.0 0.18 11.0 0.0 1.6 2 0 0 2 2 2 0 NmrA-like family ARD PF03079.9 CCF39640.1 - 3.1e-39 134.4 1.5 3.9e-39 134.1 1.1 1.1 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.6 CCF39640.1 - 2.4e-09 36.5 0.1 3.2e-09 36.1 0.1 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.14 CCF39640.1 - 0.00033 20.3 0.5 0.0004 20.0 0.4 1.3 1 1 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.17 CCF39640.1 - 0.008 15.6 0.0 0.0091 15.4 0.0 1.2 1 0 0 1 1 1 1 Cupin p450 PF00067.17 CCF39641.1 - 2.5e-34 118.6 0.0 3e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF2783 PF10932.3 CCF39641.1 - 0.073 12.5 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2783) zf-C2H2_4 PF13894.1 CCF39642.1 - 2.2e-07 30.7 14.8 0.037 14.3 0.3 5.1 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF39642.1 - 1.4e-06 28.2 12.2 0.0032 17.7 1.3 5.1 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 CCF39642.1 - 0.0015 18.6 5.9 0.035 14.2 0.8 2.9 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding Transpos_assoc PF13963.1 CCF39642.1 - 0.044 13.7 0.1 0.044 13.7 0.1 1.9 2 0 0 2 2 2 0 Transposase-associated domain zf-C2H2_6 PF13912.1 CCF39642.1 - 0.083 12.8 2.7 0.63 10.0 0.8 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.2 CCF39642.1 - 0.085 13.0 4.8 0.41 10.9 0.4 3.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.1 CCF39642.1 - 2.4 8.5 6.7 2.9 8.2 1.8 3.2 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.2 CCF39642.1 - 4.6 7.4 7.8 0.83 9.7 1.3 2.6 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) DUF629 PF04780.7 CCF39642.1 - 7.5 4.9 6.3 2.5 6.5 1.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF629) Cu-oxidase_3 PF07732.10 CCF39643.1 - 1.1e-38 131.5 3.5 2.9e-38 130.2 2.4 1.8 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 CCF39643.1 - 8.3e-35 119.2 1.7 8.3e-35 119.2 1.2 3.4 3 1 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.17 CCF39643.1 - 3e-24 85.7 0.1 3e-24 85.7 0.0 2.5 3 1 0 3 3 3 1 Multicopper oxidase DUF3669 PF12417.3 CCF39645.1 - 1.8e-27 94.8 0.2 3.1e-27 94.0 0.1 1.4 1 0 0 1 1 1 1 Zinc finger protein Metallophos PF00149.23 CCF39646.1 - 4.2e-09 36.0 0.0 6.1e-07 29.0 0.0 2.3 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CCF39646.1 - 3.9e-07 30.0 0.0 5.5e-07 29.5 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF359 PF04019.7 CCF39646.1 - 0.15 11.4 0.0 3.6 7.0 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF359) HORMA PF02301.13 CCF39647.1 - 6.2e-46 156.4 0.0 7.6e-46 156.2 0.0 1.1 1 0 0 1 1 1 1 HORMA domain UCH PF00443.24 CCF39648.1 - 1.2e-42 145.9 0.0 2.7e-42 144.7 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 CCF39648.1 - 1.5e-22 79.4 14.5 1.6e-19 69.7 1.7 3.1 3 0 0 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.26 CCF39648.1 - 2e-20 72.0 0.3 5.3e-09 35.6 0.0 2.7 2 0 0 2 2 2 2 UBA/TS-N domain UCH_1 PF13423.1 CCF39648.1 - 2.2e-17 63.4 0.0 4.9e-10 39.3 0.0 3.2 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UBA_3 PF09288.5 CCF39648.1 - 0.064 12.8 0.0 1.1 8.8 0.0 2.9 3 0 0 3 3 3 0 Fungal ubiquitin-associated domain NifU_N PF01592.11 CCF39649.1 - 1.1e-50 170.8 0.0 1.4e-50 170.4 0.0 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain zf-CCCH PF00642.19 CCF39651.1 - 5.1e-22 77.0 33.0 5.5e-08 32.3 0.4 5.5 4 1 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 CCF39651.1 - 0.0017 18.2 33.2 0.037 14.0 0.4 5.9 5 1 0 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type LRV_FeS PF05484.6 CCF39651.1 - 2.7 7.6 12.7 9.7 5.8 0.1 4.2 3 1 1 4 4 4 0 LRV protein FeS4 cluster RRS1 PF04939.7 CCF39653.1 - 0.064 12.7 0.8 0.11 11.9 0.5 1.3 1 0 0 1 1 1 0 Ribosome biogenesis regulatory protein (RRS1) Fungal_trans PF04082.13 CCF39655.1 - 9.1e-19 67.3 0.1 9.1e-19 67.3 0.1 1.9 3 0 0 3 3 3 1 Fungal specific transcription factor domain GDPD PF03009.12 CCF39656.1 - 2.8e-09 36.8 0.0 3.9e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.1 CCF39656.1 - 1.9e-06 27.8 0.9 3.7e-06 26.9 0.6 1.6 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD PF03009.12 CCF39657.1 - 6.7e-17 61.8 0.0 7.4e-17 61.7 0.0 1.0 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family MFS_1 PF07690.11 CCF39658.1 - 3.9e-28 98.1 32.7 3.9e-28 98.1 22.7 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Imm32 PF15579.1 CCF39659.1 - 0.058 12.9 0.2 0.79 9.3 0.0 2.5 2 0 0 2 2 2 0 Immunity protein 32 Fungal_trans PF04082.13 CCF39661.1 - 1.7e-06 27.0 0.0 2.9e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain KcnmB2_inactiv PF09303.5 CCF39661.1 - 0.013 15.2 0.4 0.15 11.8 0.1 2.3 2 0 0 2 2 2 0 KCNMB2, ball and chain domain NAD_binding_2 PF03446.10 CCF39663.1 - 4.3e-71 238.0 1.6 7.3e-37 126.7 1.1 2.8 2 0 0 2 2 2 2 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 CCF39663.1 - 1.2e-66 222.3 1.1 7e-34 116.5 0.1 2.5 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase DUF1537 PF07005.6 CCF39663.1 - 5e-25 88.4 7.7 7.1e-25 87.9 3.8 2.4 2 1 0 2 2 2 1 Protein of unknown function, DUF1537 F420_oxidored PF03807.12 CCF39663.1 - 1.5e-12 47.8 0.9 3.7e-05 24.0 0.3 5.1 4 1 1 5 5 5 2 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 CCF39663.1 - 2.5e-11 43.0 0.0 4.8e-06 25.8 0.0 2.5 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 CCF39663.1 - 3.8e-06 26.6 2.6 0.00067 19.3 0.4 2.5 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.11 CCF39663.1 - 0.00048 19.5 0.5 0.17 11.3 0.1 2.8 2 0 0 2 2 2 2 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.9 CCF39663.1 - 0.0014 18.0 2.3 0.41 10.0 0.0 4.0 3 1 1 4 4 4 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.10 CCF39663.1 - 0.0016 18.5 0.0 1.1 9.4 0.0 2.7 2 0 0 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain WD40 PF00400.27 CCF39664.1 - 0.022 14.6 1.0 0.076 12.9 0.0 2.4 3 0 0 3 3 3 0 WD domain, G-beta repeat PAT1 PF09770.4 CCF39664.1 - 0.86 7.7 2.6 1.1 7.3 1.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Proteasome PF00227.21 CCF39665.1 - 7.5e-47 159.0 0.1 9.1e-47 158.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.3 CCF39665.1 - 4.7e-12 44.9 0.1 1.1e-11 43.7 0.1 1.7 1 0 0 1 1 1 1 Proteasome beta subunits C terminal Sel1 PF08238.7 CCF39666.1 - 4.2e-13 49.4 9.8 0.0021 18.6 0.1 4.6 4 0 0 4 4 4 3 Sel1 repeat DUF2993 PF11209.3 CCF39668.1 - 0.034 14.0 1.6 0.041 13.8 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2993) adh_short PF00106.20 CCF39669.1 - 8.6e-31 107.1 0.5 1.5e-30 106.3 0.3 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF39669.1 - 3.1e-23 82.8 0.0 1.5e-22 80.5 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF39669.1 - 8.5e-15 54.8 0.2 1.2e-14 54.3 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF39669.1 - 0.0003 20.2 0.1 0.0012 18.2 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 CCF39669.1 - 0.002 17.1 0.1 0.015 14.1 0.1 2.4 1 1 0 1 1 1 1 Male sterility protein Yae1_N PF09811.4 CCF39670.1 - 1.6e-08 33.9 5.4 2.3e-08 33.4 3.7 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Ribosomal_60s PF00428.14 CCF39670.1 - 0.057 13.8 4.5 1.9 8.9 0.4 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein Trns_repr_metal PF02583.12 CCF39670.1 - 0.13 12.4 0.0 0.29 11.3 0.0 1.6 1 0 0 1 1 1 0 Metal-sensitive transcriptional repressor DUF3446 PF11928.3 CCF39670.1 - 0.39 10.9 5.0 0.64 10.2 3.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) DUF2370 PF10176.4 CCF39671.1 - 0.096 12.0 0.1 0.1 11.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) His_Phos_2 PF00328.17 CCF39672.1 - 2.9e-11 43.3 0.2 1.8e-08 34.0 0.0 2.5 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) PDGLE PF13190.1 CCF39672.1 - 0.027 14.1 0.7 0.07 12.8 0.1 2.1 3 0 0 3 3 3 0 PDGLE domain DUF575 PF04746.7 CCF39672.1 - 0.099 12.6 0.5 0.16 11.9 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF575) Git3 PF11710.3 CCF39673.1 - 1.5e-18 67.0 12.8 3.1e-18 66.0 8.9 1.5 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Git3_C PF11970.3 CCF39673.1 - 9.2e-09 34.9 0.1 9.2e-09 34.9 0.1 2.5 3 0 0 3 3 3 1 G protein-coupled glucose receptor regulating Gpa2 C-term PIG-P PF08510.7 CCF39673.1 - 0.12 11.9 3.4 0.65 9.6 0.0 2.6 2 1 0 2 2 2 0 PIG-P Cutinase PF01083.17 CCF39674.1 - 3.5e-47 160.4 4.5 4.4e-47 160.1 3.1 1.0 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.6 CCF39674.1 - 7.9e-05 22.1 0.1 0.00013 21.4 0.1 1.4 1 0 0 1 1 1 1 PE-PPE domain Abhydrolase_5 PF12695.2 CCF39674.1 - 0.0019 17.9 0.1 0.0022 17.7 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 CCF39674.1 - 0.0029 17.2 0.2 0.0058 16.2 0.1 1.5 1 1 1 2 2 2 1 alpha/beta hydrolase fold VirJ PF06057.6 CCF39674.1 - 0.0061 16.3 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) Abhydrolase_6 PF12697.2 CCF39674.1 - 0.09 12.6 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Amidase PF01425.16 CCF39676.1 - 7.9e-27 94.1 0.0 2.3e-26 92.6 0.0 1.6 1 1 1 2 2 2 1 Amidase Prolamin_like PF05617.6 CCF39677.1 - 5.3 7.2 6.9 1.7 8.8 0.3 2.2 2 0 0 2 2 2 0 Prolamin-like UDG PF03167.14 CCF39679.1 - 6.4e-21 74.4 0.1 6.7e-20 71.1 0.0 2.1 2 0 0 2 2 2 1 Uracil DNA glycosylase superfamily POR_N PF01855.14 CCF39679.1 - 0.12 11.8 0.2 0.2 11.1 0.1 1.2 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Aldedh PF00171.17 CCF39681.1 - 1.6e-31 109.2 0.2 1.7e-31 109.0 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family tRNA-synt_2b PF00587.20 CCF39682.1 - 1e-45 155.4 0.0 1.6e-45 154.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 CCF39682.1 - 1.5e-10 40.9 0.2 4.2e-10 39.4 0.0 1.8 2 0 0 2 2 2 1 Anticodon binding domain HLH PF00010.21 CCF39683.1 - 2.1e-08 33.7 0.0 3.4e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Umbravirus_LDM PF04817.7 CCF39683.1 - 0.0078 15.3 0.1 0.0091 15.1 0.1 1.1 1 0 0 1 1 1 1 Umbravirus long distance movement (LDM) family Rab5-bind PF09311.6 CCF39683.1 - 0.02 14.8 1.4 0.025 14.4 0.9 1.2 1 0 0 1 1 1 0 Rabaptin-like protein Methyltransf_23 PF13489.1 CCF39684.1 - 4.9e-20 71.8 0.0 6.9e-20 71.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF39684.1 - 1.9e-08 34.8 0.0 2.4e-07 31.3 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF39684.1 - 6.9e-06 26.4 0.0 1.2e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF39684.1 - 5e-05 22.9 0.0 0.00024 20.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF39684.1 - 6.9e-05 23.2 0.0 0.00034 21.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 CCF39684.1 - 0.012 14.8 0.0 0.65 9.1 0.0 2.3 2 0 0 2 2 2 0 O-methyltransferase Methyltransf_16 PF10294.4 CCF39684.1 - 0.014 14.9 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_25 PF13649.1 CCF39684.1 - 0.016 15.5 0.0 0.041 14.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 CCF39684.1 - 0.036 13.4 0.0 0.065 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Imm34 PF15596.1 CCF39685.1 - 0.024 14.7 0.1 0.091 12.9 0.0 1.9 2 0 0 2 2 2 0 Immunity protein 34 Methyltransf_10 PF05971.7 CCF39686.1 - 5.4e-66 222.7 0.0 7.2e-66 222.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF890) Methyltransf_26 PF13659.1 CCF39686.1 - 1.8e-05 24.7 0.0 3.4e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF39686.1 - 1.9e-05 24.0 0.0 3.2e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.2 CCF39686.1 - 4.4e-05 24.0 0.0 0.00013 22.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 CCF39686.1 - 0.00074 18.7 0.0 0.0034 16.5 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.13 CCF39686.1 - 0.0012 18.4 0.0 0.0022 17.5 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.1 CCF39686.1 - 0.075 13.4 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 CCF39686.1 - 0.13 12.7 0.0 0.27 11.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain E1-E2_ATPase PF00122.15 CCF39687.1 - 1.1e-12 47.5 0.0 3e-12 46.0 0.0 1.7 2 0 0 2 2 2 1 E1-E2 ATPase HAD PF12710.2 CCF39687.1 - 2.5e-12 47.3 0.0 6.3e-12 46.0 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF39687.1 - 1.1e-11 44.5 0.0 2.9e-11 43.1 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase PF00702.21 CCF39687.1 - 7.8e-11 42.7 1.2 1.3e-08 35.4 0.8 3.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CCF39687.1 - 0.011 15.3 0.6 0.022 14.3 0.5 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Aldedh PF00171.17 CCF39688.1 - 1e-114 383.4 0.0 1.3e-114 383.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DEAD PF00270.24 CCF39689.1 - 1.6e-39 135.1 0.0 2.7e-39 134.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF39689.1 - 1.7e-22 79.0 0.0 3.5e-22 78.0 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 CCF39689.1 - 0.00021 20.1 0.0 0.00031 19.6 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain SecA_DEAD PF07517.9 CCF39689.1 - 0.087 12.0 0.1 4.4 6.5 0.0 2.1 2 0 0 2 2 2 0 SecA DEAD-like domain DUF1253 PF06862.7 CCF39689.1 - 0.12 10.7 0.0 6.3 5.0 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1253) ResIII PF04851.10 CCF39689.1 - 0.16 11.8 0.0 0.33 10.7 0.0 1.5 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Ipi1_N PF12333.3 CCF39690.1 - 1e-23 83.2 0.1 2.6e-23 81.9 0.0 1.7 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation TPR_20 PF14561.1 CCF39690.1 - 0.083 13.0 0.1 0.2 11.8 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Sugar_tr PF00083.19 CCF39691.1 - 1.7e-69 234.6 18.6 1.9e-69 234.4 12.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF39691.1 - 5.3e-14 51.7 25.2 5.3e-14 51.7 17.4 2.3 1 1 2 3 3 3 1 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF39691.1 - 0.00038 20.1 0.1 0.00038 20.1 0.1 3.4 4 0 0 4 4 4 1 MFS_1 like family MFS_2 PF13347.1 CCF39691.1 - 0.0051 15.2 0.8 0.0051 15.2 0.6 3.9 2 2 1 4 4 4 2 MFS/sugar transport protein SMP_2 PF10144.4 CCF39691.1 - 0.14 11.2 0.1 0.24 10.4 0.1 1.3 1 0 0 1 1 1 0 Bacterial virulence factor haemolysin FMO-like PF00743.14 CCF39692.1 - 9.5e-32 109.8 0.0 1.2e-31 109.6 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 CCF39692.1 - 7.6e-16 58.7 0.0 8.3e-16 58.6 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF39692.1 - 1.5e-08 34.5 0.0 8.4e-08 32.1 0.0 1.9 1 1 0 1 1 1 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 CCF39692.1 - 4.3e-07 29.8 0.1 7.1e-07 29.1 0.1 1.6 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF39692.1 - 2.6e-06 27.4 0.0 3.9e-06 26.8 0.0 1.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF39692.1 - 4.1e-06 25.9 0.4 6e-05 22.1 0.1 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.22 CCF39692.1 - 0.00036 20.8 0.0 0.02 15.2 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF39692.1 - 0.00082 18.3 0.1 0.021 13.7 0.0 2.0 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_10 PF13460.1 CCF39692.1 - 0.0013 18.7 0.3 0.01 15.8 0.1 2.0 1 1 0 2 2 2 1 NADH(P)-binding FAD_binding_3 PF01494.14 CCF39692.1 - 0.018 14.1 0.2 0.11 11.4 0.0 1.9 1 1 0 2 2 2 0 FAD binding domain IlvN PF07991.7 CCF39692.1 - 0.038 13.3 0.0 0.056 12.8 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain Occludin_ELL PF07303.8 CCF39692.1 - 0.05 14.3 0.7 0.069 13.8 0.5 1.2 1 0 0 1 1 1 0 Occludin homology domain HI0933_like PF03486.9 CCF39692.1 - 0.13 10.7 0.0 0.39 9.1 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.12 CCF39692.1 - 0.15 11.1 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Thi4 family adh_short PF00106.20 CCF39693.1 - 4.3e-25 88.5 0.8 5.7e-25 88.1 0.6 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF39693.1 - 2.8e-23 82.9 0.0 4e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF39693.1 - 2.4e-08 33.8 0.1 3.4e-08 33.3 0.1 1.3 1 0 0 1 1 1 1 KR domain PC_rep PF01851.17 CCF39694.1 - 2.9e-44 146.8 12.7 4.4e-08 32.9 0.0 9.1 8 0 0 8 8 8 8 Proteasome/cyclosome repeat HEAT_2 PF13646.1 CCF39694.1 - 4.6e-18 65.2 0.1 2.7e-12 46.7 0.0 5.0 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.17 CCF39694.1 - 1.6e-07 30.8 3.4 1.8 8.8 0.0 6.5 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.1 CCF39694.1 - 1.2e-05 25.6 3.3 0.00078 19.8 0.0 5.0 5 1 0 5 5 5 1 HEAT-like repeat ILVD_EDD PF00920.16 CCF39695.1 - 1.2e-39 136.1 0.2 1.3e-39 136.0 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family Glyco_transf_15 PF01793.11 CCF39696.1 - 3.2e-124 414.1 0.3 4.2e-124 413.8 0.2 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase UDPGP PF01704.13 CCF39696.1 - 0.19 10.1 0.0 0.29 9.6 0.0 1.1 1 0 0 1 1 1 0 UTP--glucose-1-phosphate uridylyltransferase DUF3328 PF11807.3 CCF39697.1 - 1.7e-20 73.6 8.5 2.1e-20 73.3 5.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Pox_T4_C PF04490.7 CCF39697.1 - 0.016 14.9 0.5 0.022 14.5 0.3 1.3 1 1 0 1 1 1 0 Poxvirus T4 protein, C terminus Abhydro_lipase PF04083.11 CCF39700.1 - 4.2e-10 38.8 0.0 8.1e-10 37.9 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region DUF4604 PF15377.1 CCF39700.1 - 0.086 13.0 0.3 0.086 13.0 0.2 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4604) SurE PF01975.12 CCF39701.1 - 1.8e-26 92.7 0.0 2.5e-26 92.1 0.0 1.2 1 0 0 1 1 1 1 Survival protein SurE GvpD PF07088.6 CCF39704.1 - 0.19 9.9 0.5 0.73 8.0 0.0 2.0 3 0 0 3 3 3 0 GvpD gas vesicle protein Carn_acyltransf PF00755.15 CCF39705.1 - 2.8e-120 402.1 0.1 3.3e-120 401.9 0.1 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase SWIRM PF04433.12 CCF39706.1 - 2.9e-34 117.0 0.1 5.3e-34 116.2 0.1 1.5 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-binding PF00249.26 CCF39706.1 - 6.5e-08 32.5 0.0 1.9e-07 30.9 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CCF39706.1 - 1.9e-06 27.8 0.2 8e-06 25.8 0.0 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain ZZ PF00569.12 CCF39706.1 - 0.00099 18.6 4.0 0.002 17.6 2.8 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type ETF PF01012.16 CCF39707.1 - 3e-40 137.6 0.2 5.6e-40 136.7 0.1 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.14 CCF39707.1 - 1.3e-36 124.1 0.9 2.4e-36 123.2 0.1 1.8 2 0 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain Involucrin PF00904.12 CCF39707.1 - 9.7 7.0 5.9 0.52 10.9 0.4 1.8 2 0 0 2 2 2 0 Involucrin repeat Pyr_redox_2 PF07992.9 CCF39708.1 - 1.4e-07 31.6 0.0 1.9e-06 27.9 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF39708.1 - 3.3e-05 24.0 0.0 0.0051 16.8 0.0 2.3 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF39708.1 - 0.051 13.6 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 CCF39708.1 - 0.11 10.9 0.0 0.17 10.3 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein XRN_N PF03159.13 CCF39710.1 - 1.7e-107 358.2 0.0 3.4e-107 357.2 0.0 1.5 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus PROL5-SMR PF15621.1 CCF39710.1 - 0.72 10.3 16.6 2.7 8.4 11.5 2.0 1 0 0 1 1 1 0 Proline-rich submaxillary gland androgen-regulated family NAD_binding_8 PF13450.1 CCF39711.1 - 3.2e-05 23.8 0.0 3.9e-05 23.5 0.0 1.3 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 CCF39711.1 - 0.0002 20.5 0.0 0.00021 20.4 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 CCF39711.1 - 0.0085 15.2 0.0 0.01 14.9 0.0 1.1 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.7 CCF39711.1 - 0.0099 14.8 0.0 0.01 14.8 0.0 1.0 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.19 CCF39711.1 - 0.012 14.5 0.0 0.012 14.5 0.0 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 CCF39711.1 - 0.035 13.8 0.1 0.041 13.6 0.0 1.2 1 1 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.22 CCF39711.1 - 0.038 14.3 0.0 0.049 14.0 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF39711.1 - 0.054 11.9 0.0 0.061 11.7 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_3 PF13738.1 CCF39711.1 - 0.13 12.2 0.0 0.13 12.2 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lactamase_B_3 PF13483.1 CCF39714.1 - 1.6e-08 34.4 0.0 3.1e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DUF962 PF06127.6 CCF39715.1 - 8.3e-27 92.9 0.0 1.5e-26 92.0 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF962) SHS2_Rpb7-N PF03876.12 CCF39716.1 - 1e-15 57.6 0.0 1.7e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.18 CCF39716.1 - 8.5e-12 44.9 0.0 1.3e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 S1 RNA binding domain Fungal_trans_2 PF11951.3 CCF39717.1 - 5.5e-71 239.1 2.8 8e-71 238.6 1.9 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF39717.1 - 6e-09 35.6 6.2 1.4e-08 34.5 4.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Adeno_E1A PF02703.9 CCF39717.1 - 0.13 11.6 1.3 0.26 10.6 0.9 1.5 1 0 0 1 1 1 0 Early E1A protein OPT PF03169.10 CCF39718.1 - 1.3e-161 539.1 41.0 1.5e-161 538.9 28.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Ribosomal_S25 PF03297.10 CCF39719.1 - 1.7e-40 137.2 4.5 1.9e-40 137.1 3.1 1.0 1 0 0 1 1 1 1 S25 ribosomal protein HTH_24 PF13412.1 CCF39719.1 - 0.0029 16.9 0.1 0.0042 16.4 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_DeoR PF08220.7 CCF39719.1 - 0.013 14.9 0.1 0.026 14.0 0.0 1.5 1 1 1 2 2 2 0 DeoR-like helix-turn-helix domain MarR_2 PF12802.2 CCF39719.1 - 0.031 13.9 0.0 0.036 13.7 0.0 1.2 1 0 0 1 1 1 0 MarR family Rrf2 PF02082.15 CCF39719.1 - 0.099 12.7 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator Glyco_hydro_61 PF03443.9 CCF39722.1 - 1.7e-45 155.5 0.0 2.2e-45 155.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Gin PF10764.4 CCF39723.1 - 0.04 13.6 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 Inhibitor of sigma-G Gin zf-met2 PF12907.2 CCF39723.1 - 0.27 11.2 1.6 0.46 10.4 1.1 1.5 1 1 0 1 1 1 0 Zinc-binding Peptidase_M43 PF05572.8 CCF39724.1 - 1.2e-14 54.2 0.5 1.9e-14 53.5 0.3 1.3 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_2 PF13574.1 CCF39724.1 - 5.5e-07 29.8 0.2 8.3e-07 29.2 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.1 CCF39724.1 - 2.1e-06 28.2 0.5 3.5e-06 27.5 0.3 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 CCF39724.1 - 2.8e-06 27.4 0.2 4e-06 26.8 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M10 PF00413.19 CCF39724.1 - 1.3e-05 24.9 0.0 2.3e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Matrixin Reprolysin_4 PF13583.1 CCF39724.1 - 0.00024 20.6 0.1 0.00038 20.0 0.1 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.4 CCF39724.1 - 0.017 13.9 0.4 0.023 13.5 0.3 1.2 1 0 0 1 1 1 0 Peptidase M66 Ecm33 PF12454.3 CCF39724.1 - 0.049 13.5 0.4 0.15 11.9 0.1 1.9 2 0 0 2 2 2 0 GPI-anchored cell wall organization protein p450 PF00067.17 CCF39725.1 - 9.5e-55 185.9 0.0 1.2e-54 185.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1399 PF07173.7 CCF39726.1 - 1.7e-22 80.1 0.0 3.3e-18 66.3 0.0 2.7 2 1 0 2 2 2 2 Protein of unknown function (DUF1399) Kelch_5 PF13854.1 CCF39727.1 - 2.4e-10 40.1 1.9 5.8e-08 32.5 0.0 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.1 CCF39727.1 - 0.01 15.6 7.1 0.52 10.1 0.3 3.5 3 2 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.10 CCF39727.1 - 0.072 12.8 2.2 0.96 9.3 0.1 3.0 3 1 0 3 3 3 0 Kelch motif ADH_N PF08240.7 CCF39729.1 - 1.2e-27 95.7 0.3 2.4e-27 94.8 0.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF39729.1 - 9.1e-24 83.4 0.9 1.6e-23 82.6 0.6 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF39729.1 - 0.032 15.1 0.1 0.063 14.1 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase AdoHcyase_NAD PF00670.16 CCF39729.1 - 0.075 12.8 0.6 0.22 11.3 0.4 1.8 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 CCF39729.1 - 0.087 11.9 0.1 0.24 10.5 0.1 1.6 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MFS_1 PF07690.11 CCF39730.1 - 3.2e-31 108.3 70.1 7.2e-21 74.2 24.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Cupin_2 PF07883.6 CCF39731.1 - 7.1e-15 54.2 0.1 1.5e-14 53.2 0.0 1.5 2 0 0 2 2 2 1 Cupin domain AraC_binding PF02311.14 CCF39731.1 - 0.00018 21.1 0.0 0.00025 20.7 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.17 CCF39731.1 - 0.00087 18.7 0.0 0.0014 18.0 0.0 1.3 1 1 0 1 1 1 1 Cupin CENP-C_C PF11699.3 CCF39731.1 - 0.0016 18.3 0.0 0.0021 17.9 0.0 1.2 1 0 0 1 1 1 1 Mif2/CENP-C like MannoseP_isomer PF01050.13 CCF39731.1 - 0.011 15.3 0.0 0.012 15.1 0.0 1.1 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase Cupin_6 PF12852.2 CCF39731.1 - 0.012 15.2 0.0 0.03 13.9 0.0 1.6 1 1 1 2 2 2 0 Cupin PAS_9 PF13426.1 CCF39732.1 - 6.1e-19 68.3 0.0 8e-19 67.9 0.0 1.2 1 0 0 1 1 1 1 PAS domain PAS PF00989.19 CCF39732.1 - 9.2e-05 22.2 0.0 0.0024 17.6 0.0 2.1 1 1 0 1 1 1 1 PAS fold DUF3437 PF11919.3 CCF39733.1 - 4.5e-32 109.6 0.0 1.3e-31 108.1 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) HEAT PF02985.17 CCF39733.1 - 0.0039 17.1 2.4 6.6 7.0 0.1 5.3 5 0 0 5 5 5 1 HEAT repeat Methyltransf_11 PF08241.7 CCF39734.1 - 1.4e-10 41.5 0.0 3.6e-10 40.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF39734.1 - 0.00086 19.0 0.0 0.0021 17.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF39734.1 - 0.025 13.7 0.0 0.042 12.9 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 CCF39734.1 - 0.11 13.0 0.0 0.33 11.5 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_8 PF05148.10 CCF39734.1 - 0.16 11.5 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase SOBP PF15279.1 CCF39735.1 - 4.9e-08 33.7 6.4 4.9e-08 33.7 4.4 2.1 2 0 0 2 2 2 1 Sine oculis-binding protein Aspzincin_M35 PF14521.1 CCF39735.1 - 0.0023 18.4 0.0 0.0043 17.5 0.0 1.4 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase PhyH PF05721.8 CCF39737.1 - 6e-21 75.4 0.1 7.8e-21 75.0 0.1 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Lon_C PF05362.8 CCF39738.1 - 5.9e-64 215.1 0.0 1e-63 214.3 0.0 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON PF02190.11 CCF39738.1 - 8e-37 126.9 0.6 4e-36 124.6 0.4 2.2 1 1 0 1 1 1 1 ATP-dependent protease La (LON) domain AAA PF00004.24 CCF39738.1 - 5.1e-22 78.4 0.0 1.7e-21 76.7 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.1 CCF39738.1 - 4.1e-07 29.5 0.1 1.7e-06 27.5 0.0 2.0 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_2 PF07724.9 CCF39738.1 - 4.5e-07 29.9 0.0 2.1e-06 27.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 CCF39738.1 - 1.2e-06 28.3 0.0 2.9e-06 27.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 CCF39738.1 - 8.2e-06 26.6 0.2 4.5e-05 24.2 0.0 2.4 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.1 CCF39738.1 - 9.3e-06 25.8 0.1 0.00021 21.4 0.0 2.8 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.1 CCF39738.1 - 7.9e-05 22.7 2.0 0.0028 17.6 0.0 3.2 3 1 0 3 3 3 1 AAA ATPase domain AAA_PrkA PF08298.6 CCF39738.1 - 0.00012 20.9 0.0 0.00024 19.9 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain RuvB_N PF05496.7 CCF39738.1 - 0.00032 19.8 0.0 0.002 17.1 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 CCF39738.1 - 0.0026 17.6 0.0 0.01 15.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 CCF39738.1 - 0.0046 17.2 0.0 0.0046 17.2 0.0 3.1 4 0 0 4 4 1 1 AAA domain MobB PF03205.9 CCF39738.1 - 0.013 15.1 0.0 0.04 13.6 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B TIP49 PF06068.8 CCF39738.1 - 0.014 14.1 0.2 0.51 8.9 0.0 2.3 2 0 0 2 2 2 0 TIP49 C-terminus IstB_IS21 PF01695.12 CCF39738.1 - 0.014 14.7 0.1 0.07 12.5 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein RNA_helicase PF00910.17 CCF39738.1 - 0.02 15.0 0.0 0.084 13.0 0.0 2.2 1 0 0 1 1 1 0 RNA helicase ATP-synt_ab PF00006.20 CCF39738.1 - 0.024 14.1 0.1 0.15 11.5 0.0 2.0 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain MMR_HSR1 PF01926.18 CCF39738.1 - 0.03 14.2 0.2 3.4 7.6 0.0 2.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF258 PF03193.11 CCF39738.1 - 0.032 13.4 0.4 0.075 12.2 0.0 1.8 2 0 0 2 2 1 0 Protein of unknown function, DUF258 NTPase_1 PF03266.10 CCF39738.1 - 0.039 13.6 0.2 0.78 9.4 0.0 2.6 1 1 1 2 2 2 0 NTPase AAA_28 PF13521.1 CCF39738.1 - 0.048 13.6 0.5 2.3 8.1 0.0 3.2 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.1 CCF39738.1 - 0.063 12.6 0.0 0.16 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 CCF39738.1 - 0.074 12.9 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.1 CCF39738.1 - 0.17 11.7 0.2 1.6 8.6 0.0 2.3 1 1 1 2 2 2 0 AAA domain ClpB_D2-small PF10431.4 CCF39738.1 - 0.22 11.4 5.7 0.082 12.8 0.4 2.6 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein ABC_tran PF00005.22 CCF39738.1 - 1.1 9.5 5.3 0.6 10.4 0.0 2.9 3 0 0 3 3 3 0 ABC transporter eIF3_subunit PF08597.5 CCF39739.1 - 7.1 6.1 17.2 0.34 10.4 1.5 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit Avl9 PF09794.4 CCF39740.1 - 1.1e-144 481.6 0.0 1.4e-144 481.2 0.0 1.1 1 0 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.4 CCF39740.1 - 3.2e-07 29.9 1.2 3.3e-06 26.5 0.1 2.9 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) SPA PF08616.5 CCF39740.1 - 6.9e-07 28.9 0.1 0.00028 20.5 0.0 2.3 2 0 0 2 2 2 2 Stabilization of polarity axis AAA PF00004.24 CCF39744.1 - 5.1e-15 55.8 0.0 1.1e-14 54.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CCF39744.1 - 0.0011 19.0 0.2 0.061 13.4 0.0 2.7 1 1 1 3 3 3 1 AAA domain AAA_5 PF07728.9 CCF39744.1 - 0.0016 18.2 0.0 0.0036 17.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 CCF39744.1 - 0.017 14.8 0.0 0.073 12.8 0.0 2.0 2 0 0 2 2 2 0 Part of AAA domain AAA_16 PF13191.1 CCF39744.1 - 0.018 14.9 0.0 0.041 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain CPT PF07931.7 CCF39744.1 - 0.095 12.3 0.0 0.93 9.0 0.0 2.2 1 1 1 2 2 2 0 Chloramphenicol phosphotransferase-like protein Zot PF05707.7 CCF39744.1 - 0.11 12.0 0.2 7.2 6.0 0.0 2.7 2 1 1 3 3 3 0 Zonular occludens toxin (Zot) DUF1479 PF07350.7 CCF39745.1 - 1.1e-23 83.4 0.0 1.4e-23 83.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) K_channel_TID PF07941.6 CCF39748.1 - 0.24 11.6 4.3 0.37 11.0 2.8 1.6 1 1 1 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain HTH_psq PF05225.11 CCF39750.1 - 0.041 13.4 0.0 0.06 12.9 0.0 1.3 1 0 0 1 1 1 0 helix-turn-helix, Psq domain OPT PF03169.10 CCF39751.1 - 2.6e-40 138.5 0.6 2.9e-40 138.3 0.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein EmrE PF13536.1 CCF39751.1 - 0.61 10.3 4.3 0.78 9.9 0.8 2.1 2 0 0 2 2 2 0 Multidrug resistance efflux transporter SR-25 PF10500.4 CCF39754.1 - 0.095 12.1 8.8 0.11 11.9 6.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Corona_nucleoca PF00937.13 CCF39754.1 - 0.35 9.7 5.9 0.4 9.5 4.1 1.0 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Herpes_capsid PF06112.6 CCF39754.1 - 0.44 10.5 7.3 0.51 10.3 5.1 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Rad1 PF02144.11 CCF39755.1 - 4.9e-81 271.5 0.0 5.7e-81 271.2 0.0 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Bromodomain PF00439.20 CCF39756.1 - 4.2e-26 90.6 0.4 8.1e-26 89.7 0.3 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_7 PF13508.1 CCF39756.1 - 1.9e-09 37.5 0.1 4.3e-09 36.4 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CCF39756.1 - 4.9e-09 36.1 0.0 1.1e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 CCF39756.1 - 0.084 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein DUF1656 PF07869.7 CCF39757.1 - 1.3 8.8 5.9 0.44 10.3 1.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1656) Sugar_tr PF00083.19 CCF39758.1 - 1.7e-37 129.0 34.1 7.6e-25 87.3 9.7 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 CCF39758.1 - 5.8e-20 71.3 39.8 4.9e-10 38.6 14.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1673 PF07895.6 CCF39758.1 - 2.2 7.7 5.7 1.5 8.3 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1673) PhoD PF09423.5 CCF39759.1 - 1.6e-57 195.1 0.8 2.3e-57 194.5 0.6 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase Methyltransf_23 PF13489.1 CCF39761.1 - 1.2e-12 47.8 0.0 1.7e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF39761.1 - 4.3e-09 36.1 0.0 8.5e-09 35.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF39761.1 - 5.1e-09 36.5 0.0 8.7e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF39761.1 - 3.1e-08 33.9 0.0 1e-07 32.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF39761.1 - 8.9e-06 25.9 0.0 2e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF39761.1 - 2.9e-05 24.6 0.0 0.00049 20.6 0.0 2.7 3 1 0 3 3 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF39761.1 - 0.00059 19.0 0.0 0.0044 16.1 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family CheR PF01739.13 CCF39761.1 - 0.0033 16.7 0.0 0.048 12.9 0.0 2.4 1 1 2 3 3 3 1 CheR methyltransferase, SAM binding domain NodS PF05401.6 CCF39761.1 - 0.0042 16.5 0.0 0.007 15.7 0.0 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) MetW PF07021.7 CCF39761.1 - 0.0071 15.7 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_26 PF13659.1 CCF39761.1 - 0.013 15.5 0.1 0.07 13.1 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.14 CCF39761.1 - 0.035 14.0 0.3 0.83 9.6 0.2 2.2 1 1 0 1 1 1 0 FtsJ-like methyltransferase BMC PF00936.14 CCF39761.1 - 0.058 13.0 0.3 0.2 11.3 0.0 1.9 2 0 0 2 2 2 0 BMC domain Abhydrolase_6 PF12697.2 CCF39762.1 - 3.3e-16 59.8 0.6 4.9e-16 59.3 0.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF39762.1 - 2.2e-07 30.7 0.0 5.7e-07 29.3 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Reprolysin_5 PF13688.1 CCF39763.1 - 2.9e-56 190.5 5.8 4e-56 190.0 4.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.1 CCF39763.1 - 9.8e-48 162.4 0.4 1.5e-47 161.7 0.3 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.1 CCF39763.1 - 1.7e-43 148.7 2.1 2.5e-43 148.1 1.4 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.1 CCF39763.1 - 1.7e-21 77.0 0.2 3e-21 76.2 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.14 CCF39763.1 - 0.00027 20.5 6.6 0.023 14.2 4.6 3.3 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Peptidase_M57 PF12388.3 CCF39763.1 - 0.056 12.7 1.7 0.1 11.9 1.2 1.4 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Pep_M12B_propep PF01562.14 CCF39763.1 - 0.056 13.2 0.0 0.44 10.3 0.0 2.0 2 0 0 2 2 2 0 Reprolysin family propeptide Peptidase_M66 PF10462.4 CCF39763.1 - 0.16 10.8 1.2 0.27 10.0 0.8 1.3 1 0 0 1 1 1 0 Peptidase M66 Toxin_12 PF07740.7 CCF39764.1 - 0.18 12.3 15.7 0.4 11.1 7.0 2.4 2 0 0 2 2 2 0 Ion channel inhibitory toxin Toxin_21 PF08091.6 CCF39764.1 - 7.7 6.3 21.7 0.68 9.6 8.3 2.4 1 1 1 2 2 2 0 Spider insecticidal peptide NACHT PF05729.7 CCF39766.1 - 2.3e-06 27.3 0.0 1.3e-05 24.8 0.0 2.2 1 1 1 2 2 2 1 NACHT domain AAA_16 PF13191.1 CCF39766.1 - 0.00091 19.2 1.4 0.0086 16.0 0.1 3.0 3 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 CCF39766.1 - 0.0011 19.0 0.0 0.0037 17.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain DUF914 PF06027.7 CCF39767.1 - 5.6e-101 337.7 19.5 7.5e-101 337.3 13.5 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) EamA PF00892.15 CCF39767.1 - 4.2e-05 23.5 34.3 0.00014 21.8 9.7 2.7 2 1 1 3 3 3 2 EamA-like transporter family UAA PF08449.6 CCF39767.1 - 0.029 13.2 17.2 0.041 12.7 11.9 1.1 1 0 0 1 1 1 0 UAA transporter family TPT PF03151.11 CCF39767.1 - 0.052 13.1 22.0 0.52 9.9 4.7 2.7 2 1 0 2 2 2 0 Triose-phosphate Transporter family FUSC-like PF12805.2 CCF39767.1 - 2.1 7.2 7.3 0.11 11.4 0.8 2.0 2 1 0 2 2 2 0 FUSC-like inner membrane protein yccS Polysacc_lyase PF14099.1 CCF39769.1 - 1.3e-05 25.0 5.0 1.7e-05 24.6 3.5 1.2 1 0 0 1 1 1 1 Polysaccharide lyase PNP_UDP_1 PF01048.15 CCF39770.1 - 6.3e-10 38.4 0.5 4.1e-06 25.9 0.2 3.3 2 1 1 3 3 3 2 Phosphorylase superfamily AAA_22 PF13401.1 CCF39770.1 - 6.5e-05 23.0 0.0 0.00027 21.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 CCF39770.1 - 0.0001 22.0 0.0 0.00021 20.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.17 CCF39770.1 - 0.0017 17.2 0.0 0.38 9.5 0.0 2.3 2 0 0 2 2 2 2 NB-ARC domain AAA_16 PF13191.1 CCF39770.1 - 0.0045 16.9 0.1 0.0045 16.9 0.1 2.7 3 1 0 3 3 3 1 AAA ATPase domain Sulfotransfer_2 PF03567.9 CCF39770.1 - 0.017 14.8 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 Sulfotransferase family DUF230 PF03003.11 CCF39771.1 - 0.09 12.3 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Poxvirus proteins of unknown function BBE PF08031.7 CCF39772.1 - 1.7e-16 59.8 0.7 3.6e-16 58.7 0.5 1.6 1 0 0 1 1 1 1 Berberine and berberine like WD40 PF00400.27 CCF39774.1 - 6.8e-52 171.5 7.2 8.4e-09 34.9 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Nucleoporin_N PF08801.6 CCF39774.1 - 0.00057 18.7 1.9 0.48 9.1 0.2 2.5 1 1 0 2 2 2 2 Nup133 N terminal like SGL PF08450.7 CCF39774.1 - 0.07 12.5 1.2 1.2 8.4 0.0 3.0 2 1 1 4 4 4 0 SMP-30/Gluconolaconase/LRE-like region Asp PF00026.18 CCF39775.1 - 2.4e-26 92.7 0.0 7.4e-26 91.1 0.0 1.6 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CCF39775.1 - 0.0054 16.6 0.0 0.029 14.3 0.0 2.1 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal p450 PF00067.17 CCF39776.1 - 1.2e-51 175.7 0.0 4.3e-37 127.7 0.0 2.7 2 1 0 2 2 2 2 Cytochrome P450 DAHP_synth_1 PF00793.15 CCF39777.1 - 0.12 11.0 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 DAHP synthetase I family GST_C_3 PF14497.1 CCF39779.1 - 1.2e-11 44.9 0.0 1.9e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 CCF39779.1 - 5.8e-09 35.8 0.0 1.1e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 CCF39779.1 - 8.6e-05 22.6 0.1 0.0031 17.6 0.0 2.6 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 CCF39779.1 - 0.00056 19.7 0.0 0.0013 18.5 0.0 1.7 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Binary_toxB PF03495.9 CCF39780.1 - 2.1 6.8 6.8 0.084 11.4 0.2 1.7 2 0 0 2 2 2 0 Clostridial binary toxin B/anthrax toxin PA Pkinase PF00069.20 CCF39782.1 - 1.4e-20 73.5 0.0 2.4e-20 72.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Response_reg PF00072.19 CCF39782.1 - 1.3e-14 54.1 0.0 2.3e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Pkinase_Tyr PF07714.12 CCF39782.1 - 9.3e-06 24.8 0.0 1.6e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Fungal_trans PF04082.13 CCF39783.1 - 8.2e-16 57.6 0.0 1.3e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF39783.1 - 9.4e-08 31.8 9.8 1.8e-07 30.9 6.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HAD_2 PF13419.1 CCF39784.1 - 4e-20 72.7 0.0 5.3e-20 72.3 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Tachystatin_B PF11478.3 CCF39784.1 - 0.017 14.8 1.0 0.027 14.1 0.2 1.7 2 0 0 2 2 2 0 Antimicrobial chitin binding protein tachystatin B Hydrolase PF00702.21 CCF39784.1 - 0.067 13.5 0.0 0.078 13.3 0.0 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Arf PF00025.16 CCF39785.1 - 1.2e-07 31.1 0.0 1.3e-07 31.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 CCF39785.1 - 0.014 14.8 0.0 0.014 14.7 0.0 1.0 1 0 0 1 1 1 0 Ras family Glyco_transf_17 PF04724.8 CCF39787.1 - 5.6e-42 144.0 0.0 8.3e-42 143.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 17 PRO8NT PF08082.6 CCF39788.1 - 2.4e-77 257.7 3.1 3.1e-77 257.4 2.2 1.1 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain eIF-3c_N PF05470.7 CCF39789.1 - 8.5e-176 585.5 27.5 8.5e-176 585.5 19.0 3.2 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.22 CCF39789.1 - 2.7e-15 56.5 0.1 1.6e-14 54.0 0.0 2.5 1 0 0 1 1 1 1 PCI domain DASH_Ask1 PF08655.5 CCF39789.1 - 0.056 13.2 0.3 0.54 10.1 0.1 2.5 2 0 0 2 2 2 0 DASH complex subunit Ask1 Aminotran_5 PF00266.14 CCF39790.1 - 5.4e-10 38.5 0.0 2.7e-09 36.2 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 CCF39790.1 - 2.1e-05 23.0 0.0 3e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 CCF39790.1 - 0.0081 15.2 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 CCF39790.1 - 0.055 12.4 0.0 0.089 11.7 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II PHO4 PF01384.15 CCF39791.1 - 1.2e-111 372.4 16.6 1.5e-111 372.2 11.5 1.1 1 0 0 1 1 1 1 Phosphate transporter family DZR PF12773.2 CCF39792.1 - 0.18 11.6 4.9 0.82 9.5 3.4 2.0 1 1 0 1 1 1 0 Double zinc ribbon Rubredoxin PF00301.15 CCF39792.1 - 3.7 7.4 10.5 5.4 6.9 4.0 3.3 2 1 0 2 2 2 0 Rubredoxin ThiF PF00899.16 CCF39793.1 - 1.7e-12 47.2 0.0 4.6e-12 45.9 0.0 1.7 1 0 0 1 1 1 1 ThiF family HTH_Tnp_IS1 PF12759.2 CCF39794.1 - 0.097 12.1 0.2 0.15 11.5 0.1 1.3 1 0 0 1 1 1 0 InsA C-terminal domain FixQ PF05545.6 CCF39795.1 - 0.0076 15.8 0.1 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 Cbb3-type cytochrome oxidase component FixQ DUF4448 PF14610.1 CCF39795.1 - 0.06 12.8 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF1970 PF09301.5 CCF39795.1 - 0.089 12.8 0.3 0.64 10.0 0.0 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF1970) ICL PF00463.16 CCF39796.1 - 1.6e-284 943.9 0.5 1.8e-284 943.8 0.3 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.1 CCF39796.1 - 5.3e-12 45.4 0.1 1.8e-11 43.7 0.0 1.8 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase DAO PF01266.19 CCF39797.1 - 7.2e-12 44.8 0.0 7.7e-12 44.7 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF39797.1 - 7.3e-06 25.9 0.2 1.1e-05 25.3 0.1 1.4 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 CCF39797.1 - 0.00049 19.2 0.0 0.00055 19.0 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.22 CCF39797.1 - 0.0036 17.6 0.0 0.0041 17.4 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF39797.1 - 0.0037 16.2 0.0 0.0037 16.2 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_9 PF13454.1 CCF39797.1 - 0.0099 15.6 0.1 0.014 15.2 0.1 1.5 1 1 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 CCF39797.1 - 0.0099 15.9 0.0 0.0099 15.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CCF39797.1 - 0.01 15.7 0.0 0.01 15.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 CCF39797.1 - 0.015 15.3 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.13 CCF39797.1 - 0.027 14.4 0.1 0.048 13.6 0.0 1.4 2 0 0 2 2 2 0 TrkA-N domain ThiF PF00899.16 CCF39797.1 - 0.033 14.0 0.0 0.047 13.5 0.0 1.2 1 0 0 1 1 1 0 ThiF family FAD_binding_2 PF00890.19 CCF39797.1 - 0.033 13.0 0.0 0.041 12.7 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain Saccharop_dh PF03435.13 CCF39797.1 - 0.034 13.1 0.0 0.039 12.9 0.0 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase Thi4 PF01946.12 CCF39797.1 - 0.071 12.1 0.0 0.088 11.8 0.0 1.1 1 0 0 1 1 1 0 Thi4 family Ldh_1_N PF00056.18 CCF39797.1 - 0.11 12.3 0.0 0.12 12.2 0.0 1.1 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain NUDIX PF00293.23 CCF39798.1 - 1.1e-18 67.2 0.8 1.3e-18 66.8 0.5 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_2 PF13869.1 CCF39798.1 - 0.0089 15.3 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Nucleotide hydrolase LSM PF01423.17 CCF39799.1 - 8.3e-13 47.6 0.0 1.3e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 LSM domain Mob1_phocein PF03637.12 CCF39800.1 - 5.8e-71 237.7 0.0 7.4e-71 237.4 0.0 1.1 1 0 0 1 1 1 1 Mob1/phocein family OSCP PF00213.13 CCF39801.1 - 3.3e-47 160.5 1.3 5.1e-47 159.9 0.9 1.3 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit KfrA_N PF11740.3 CCF39801.1 - 6.9 7.1 9.1 0.2 12.1 0.8 2.0 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term FMO-like PF00743.14 CCF39802.1 - 2.8e-28 98.4 0.0 3.5e-19 68.4 0.0 2.4 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 CCF39802.1 - 3.4e-16 59.9 0.0 1.1e-15 58.3 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF39802.1 - 1.1e-11 44.3 0.0 4.9e-10 38.8 0.0 2.3 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 CCF39802.1 - 7.4e-10 39.0 0.0 2.8e-08 33.8 0.0 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF39802.1 - 6.8e-09 35.6 0.1 2e-07 30.9 0.0 2.5 1 1 0 1 1 1 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 CCF39802.1 - 1.1e-06 28.5 0.0 7.2e-06 25.9 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 CCF39802.1 - 1.6e-06 27.5 0.0 0.023 13.7 0.1 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase DAO PF01266.19 CCF39802.1 - 0.051 12.4 0.1 1.3 7.8 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase Thi4 PF01946.12 CCF39802.1 - 0.13 11.3 0.0 0.58 9.2 0.0 1.9 2 0 0 2 2 2 0 Thi4 family FAD_binding_3 PF01494.14 CCF39802.1 - 0.26 10.2 0.3 1.2 8.1 0.0 1.9 2 0 0 2 2 2 0 FAD binding domain Cellulase PF00150.13 CCF39803.1 - 1.3e-48 165.5 4.3 1.7e-48 165.2 3.0 1.0 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Pho88 PF10032.4 CCF39804.1 - 1.2e-78 262.7 0.0 1.4e-78 262.5 0.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) Sec16_C PF12931.2 CCF39808.1 - 6.5e-97 324.6 0.2 8.4e-97 324.3 0.1 1.1 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.2 CCF39808.1 - 1.9e-29 102.0 0.0 4e-29 100.9 0.0 1.6 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Sec16_N PF12935.2 CCF39808.1 - 2.4e-08 34.1 26.1 2.4e-08 34.1 18.1 2.4 3 0 0 3 3 3 1 Vesicle coat trafficking protein Sec16 N-terminus Git3 PF11710.3 CCF39812.1 - 1e-20 74.1 3.6 2.4e-20 72.9 2.5 1.6 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.16 CCF39812.1 - 3.5e-05 23.0 8.2 6e-05 22.3 5.7 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dicty_CAR PF05462.6 CCF39812.1 - 0.0012 17.7 5.1 0.0019 17.1 3.6 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Git3_C PF11970.3 CCF39812.1 - 0.0025 17.5 0.2 0.0067 16.1 0.1 1.7 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Sugar_tr PF00083.19 CCF39813.1 - 0.00071 18.2 3.7 0.00082 18.0 2.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter SUR7 PF06687.7 CCF39814.1 - 4.3e-05 23.1 0.1 4.3e-05 23.1 0.1 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF1191 PF06697.7 CCF39816.1 - 0.059 12.1 0.0 0.16 10.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1191) MFS_1 PF07690.11 CCF39818.1 - 5.2e-35 120.8 58.2 3.3e-28 98.4 24.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF39818.1 - 0.0002 20.0 35.0 0.0014 17.3 6.4 3.0 1 1 1 2 2 2 2 Sugar (and other) transporter DUF2461 PF09365.5 CCF39820.1 - 2.1e-74 249.4 0.5 2.1e-74 249.4 0.4 1.4 2 0 0 2 2 2 1 Conserved hypothetical protein (DUF2461) Pkinase PF00069.20 CCF39822.1 - 6.5e-20 71.3 0.0 1.9e-19 69.8 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF39822.1 - 1.4e-05 24.3 0.3 0.16 11.0 0.0 3.4 4 0 0 4 4 4 2 Protein tyrosine kinase APH PF01636.18 CCF39822.1 - 0.045 13.4 1.9 0.064 12.9 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF4380 PF14315.1 CCF39823.1 - 0.11 11.7 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4380) OTT_1508_deam PF14441.1 CCF39824.1 - 1.6e-19 70.0 0.0 3.6e-19 69.0 0.0 1.6 1 0 0 1 1 1 1 OTT_1508-like deaminase Herpes_BLRF2 PF05812.7 CCF39824.1 - 0.03 14.1 0.0 0.085 12.6 0.0 1.7 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein F-box PF00646.28 CCF39827.1 - 6.6e-09 35.1 0.5 6.6e-09 35.1 0.3 2.5 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.2 CCF39827.1 - 5.9e-08 32.3 2.6 1.6e-07 30.9 0.2 2.4 2 0 0 2 2 2 1 F-box-like RPEL PF02755.10 CCF39827.1 - 0.00093 18.4 0.0 0.0059 15.8 0.0 2.2 2 0 0 2 2 2 1 RPEL repeat PRANC PF09372.5 CCF39827.1 - 0.063 13.2 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 PRANC domain F-box-like_2 PF13013.1 CCF39827.1 - 0.13 12.0 1.8 0.23 11.2 1.3 1.7 1 1 0 1 1 1 0 F-box-like domain zf-C3HC4 PF00097.20 CCF39828.1 - 0.00032 20.3 12.4 0.00074 19.1 6.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF39828.1 - 0.00045 19.8 10.1 0.0017 18.0 7.1 1.9 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 CCF39828.1 - 0.0032 17.1 5.5 0.0071 16.0 3.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.1 CCF39828.1 - 0.0034 17.3 11.7 0.0076 16.2 8.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF39828.1 - 0.0034 17.1 11.2 0.0074 16.0 7.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 CCF39828.1 - 0.0076 15.9 10.4 0.015 14.9 7.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CCF39828.1 - 0.01 15.6 11.2 0.019 14.8 7.8 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FYVE PF01363.16 CCF39828.1 - 2.6 8.0 11.9 1.3e+02 2.5 8.2 2.6 1 1 0 1 1 1 0 FYVE zinc finger IBR PF01485.16 CCF39828.1 - 6.8 6.6 13.1 2.9e+02 1.4 9.1 2.7 1 1 0 1 1 1 0 IBR domain Peptidase_M14 PF00246.19 CCF39829.1 - 2e-37 129.2 0.1 2.8e-37 128.8 0.1 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase DUF982 PF06169.7 CCF39829.1 - 0.052 13.2 0.0 0.18 11.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF982) Arb2 PF09757.4 CCF39829.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Arb2 domain Zn_clus PF00172.13 CCF39831.1 - 7.1e-10 38.6 11.2 1.1e-09 38.0 7.8 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF695 PF05117.7 CCF39831.1 - 0.036 13.9 0.0 0.071 13.0 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF695) DUF2312 PF10073.4 CCF39831.1 - 0.37 10.1 2.5 0.23 10.8 0.4 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) Sld5 PF05916.6 CCF39833.1 - 3.7e-27 94.7 0.0 5.7e-27 94.1 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein DUF2605 PF10792.4 CCF39833.1 - 0.11 12.2 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) Pkinase PF00069.20 CCF39834.1 - 6e-12 45.2 0.0 3.3e-11 42.8 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF39834.1 - 3.2e-07 29.6 0.0 1.1e-06 27.9 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase CDC48_2 PF02933.12 CCF39834.1 - 0.073 12.7 0.1 0.18 11.4 0.1 1.6 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 Kinase-like PF14531.1 CCF39834.1 - 0.098 11.5 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Glyco_hydro_72 PF03198.9 CCF39835.1 - 7.8e-90 301.0 0.6 1.1e-88 297.2 0.4 2.0 1 1 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.13 CCF39835.1 - 0.00027 20.2 0.8 0.0012 18.1 0.6 2.0 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.12 CCF39835.1 - 0.0012 17.7 0.1 0.0027 16.6 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Malate_synthase PF01274.17 CCF39838.1 - 4.8e-133 443.9 0.0 5.4e-133 443.7 0.0 1.0 1 0 0 1 1 1 1 Malate synthase IlvC PF01450.14 CCF39839.1 - 3.2e-35 121.2 0.0 3.5e-35 121.0 0.0 1.0 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain Atg14 PF10186.4 CCF39840.1 - 0.12 11.3 9.4 0.19 10.6 6.5 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 IncA PF04156.9 CCF39840.1 - 0.12 11.9 9.1 0.21 11.1 6.3 1.3 1 0 0 1 1 1 0 IncA protein Pox_A_type_inc PF04508.7 CCF39840.1 - 0.12 12.1 4.8 0.49 10.3 1.0 3.3 2 1 0 2 2 2 0 Viral A-type inclusion protein repeat Filament PF00038.16 CCF39840.1 - 0.64 9.4 14.8 1.6 8.1 10.2 1.6 1 1 0 1 1 1 0 Intermediate filament protein 5_nucleotid PF05761.9 CCF39840.1 - 0.86 8.0 2.4 4.6 5.6 0.0 2.1 2 0 0 2 2 2 0 5' nucleotidase family TMPIT PF07851.8 CCF39840.1 - 1.5 7.7 3.0 2.3 7.2 2.1 1.2 1 0 0 1 1 1 0 TMPIT-like protein APG6 PF04111.7 CCF39840.1 - 2.1 7.3 10.4 3.9 6.4 7.2 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 V_ATPase_I PF01496.14 CCF39840.1 - 2.8 5.7 6.8 3.8 5.2 4.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GAS PF13851.1 CCF39840.1 - 5 6.2 13.3 3.3 6.8 5.1 2.4 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding ATG16 PF08614.6 CCF39840.1 - 5.6 6.7 18.0 0.62 9.8 6.6 3.0 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) ERM PF00769.14 CCF39840.1 - 8.3 5.8 22.7 0.5 9.8 12.1 1.6 2 0 0 2 2 2 0 Ezrin/radixin/moesin family DUF1308 PF07000.6 CCF39841.1 - 2.9e-34 118.2 0.0 4e-34 117.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1308) SnoaL_2 PF12680.2 CCF39842.1 - 3.1e-05 24.3 0.1 4.7e-05 23.7 0.1 1.4 1 1 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.1 CCF39842.1 - 0.0038 17.1 0.0 0.0057 16.5 0.0 1.3 1 1 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.7 CCF39842.1 - 0.052 13.1 0.0 0.073 12.6 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase WD40 PF00400.27 CCF39844.1 - 2.7e-08 33.3 11.0 0.53 10.2 0.0 7.0 8 0 0 8 8 8 3 WD domain, G-beta repeat HEAT PF02985.17 CCF39844.1 - 5e-07 29.2 0.3 0.11 12.6 0.1 4.4 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.1 CCF39844.1 - 2.1e-05 24.6 0.0 0.039 14.2 0.0 2.9 2 1 2 4 4 4 3 HEAT repeats BBS2_Mid PF14783.1 CCF39844.1 - 0.00068 19.3 0.1 1.3 8.8 0.0 2.7 1 1 1 2 2 2 2 Ciliary BBSome complex subunit 2, middle region Atx10homo_assoc PF09759.4 CCF39844.1 - 0.0089 15.7 0.1 0.017 14.8 0.1 1.4 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain Cnd1 PF12717.2 CCF39844.1 - 0.1 12.4 0.4 14 5.5 0.1 2.7 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Sugar_tr PF00083.19 CCF39845.1 - 1.1e-51 175.9 6.3 1.4e-51 175.5 4.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF39845.1 - 6.9e-11 41.4 13.8 9.1e-11 41.0 9.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Zn_clus PF00172.13 CCF39847.1 - 7.8e-07 28.9 15.5 1.3e-06 28.1 10.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CC2D2AN-C2 PF15625.1 CCF39847.1 - 0.0095 15.4 0.2 0.024 14.1 0.1 1.7 1 0 0 1 1 1 1 CC2D2A N-terminal C2 domain EMP24_GP25L PF01105.19 CCF39847.1 - 0.05 13.3 0.0 0.096 12.3 0.0 1.5 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF3138 PF11336.3 CCF39847.1 - 0.057 11.5 0.0 0.084 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) BLOC1_2 PF10046.4 CCF39847.1 - 0.16 12.1 0.6 0.3 11.2 0.1 1.7 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AATF-Che1 PF13339.1 CCF39848.1 - 8.2e-30 103.6 2.1 8.2e-30 103.6 1.4 3.1 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor TRAUB PF08164.7 CCF39848.1 - 6.1e-18 64.6 3.6 1.6e-17 63.3 0.1 2.8 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal SEN1_N PF12726.2 CCF39851.1 - 6.8e-128 427.7 8.8 1.1e-127 427.0 6.1 1.3 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.1 CCF39851.1 - 1.1e-28 100.3 10.6 2.6e-27 95.9 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.1 CCF39851.1 - 1.1e-11 44.2 0.1 3.5e-11 42.6 0.1 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 CCF39851.1 - 7.3e-06 25.6 0.1 2.5e-05 23.9 0.1 2.0 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.16 CCF39851.1 - 0.00058 19.2 1.2 0.0083 15.4 0.0 2.9 1 1 2 3 3 3 1 UvrD/REP helicase N-terminal domain AAA_25 PF13481.1 CCF39851.1 - 0.013 14.8 0.1 0.035 13.5 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 CCF39851.1 - 0.059 13.5 0.0 0.36 10.9 0.0 2.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 CCF39851.1 - 0.069 13.3 0.4 0.2 11.8 0.3 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PARP PF00644.15 CCF39852.1 - 3.6e-62 209.4 0.3 9.6e-62 208.0 0.0 1.9 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.9 CCF39852.1 - 2.7e-40 137.1 0.1 4.4e-40 136.4 0.1 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.10 CCF39852.1 - 4.2e-23 81.1 0.4 1.3e-22 79.5 0.3 1.9 1 0 0 1 1 1 1 WGR domain PTCB-BRCT PF12738.2 CCF39852.1 - 1e-11 44.5 0.3 2.8e-11 43.1 0.2 1.8 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.21 CCF39852.1 - 2.9e-10 40.1 0.0 6e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain F-box PF00646.28 CCF39853.1 - 0.00028 20.4 1.3 0.00071 19.1 0.9 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 CCF39853.1 - 0.0016 18.1 0.1 0.0031 17.2 0.1 1.4 1 0 0 1 1 1 1 F-box-like Glyco_hydro_88 PF07470.8 CCF39854.1 - 5.4e-60 203.1 4.9 6.4e-60 202.9 3.4 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Aminotran_1_2 PF00155.16 CCF39855.1 - 5.4e-30 104.5 0.0 5.9e-30 104.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II PHD PF00628.24 CCF39856.1 - 1.8e-13 49.9 16.9 1.8e-08 33.9 5.8 2.5 2 0 0 2 2 2 2 PHD-finger Prok-RING_1 PF14446.1 CCF39856.1 - 0.00019 21.0 12.8 0.015 15.0 0.7 2.6 2 0 0 2 2 2 2 Prokaryotic RING finger family 1 C1_1 PF00130.17 CCF39856.1 - 0.087 12.5 12.4 1.1 9.0 0.2 3.1 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-HC5HC2H PF13771.1 CCF39856.1 - 0.088 12.9 5.6 0.26 11.4 1.1 2.4 2 0 0 2 2 2 0 PHD-like zinc-binding domain PHD_2 PF13831.1 CCF39856.1 - 0.25 10.6 12.8 1.5 8.1 3.0 3.1 3 0 0 3 3 3 0 PHD-finger AdoMet_Synthase PF01941.14 CCF39856.1 - 0.3 9.5 0.0 0.45 8.9 0.0 1.2 1 0 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) zf-PHD-like PF15446.1 CCF39856.1 - 5.3 6.2 12.1 11 5.2 0.2 3.1 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain Sugar_tr PF00083.19 CCF39857.1 - 4.8e-81 272.6 19.7 5.6e-81 272.4 13.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF39857.1 - 1.7e-17 63.2 26.8 2.3e-16 59.4 14.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CCF39857.1 - 9.6e-06 24.2 21.2 0.00033 19.1 5.8 2.6 2 1 0 2 2 2 2 MFS/sugar transport protein Folate_carrier PF01770.13 CCF39857.1 - 0.001 17.6 1.7 0.0021 16.6 1.2 1.6 1 1 0 1 1 1 1 Reduced folate carrier Fungal_trans PF04082.13 CCF39858.1 - 0.0031 16.4 0.7 0.0053 15.6 0.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain TCL1_MTCP1 PF01840.12 CCF39858.1 - 0.12 11.9 0.3 0.28 10.7 0.1 1.7 2 0 0 2 2 2 0 TCL1/MTCP1 family Pro_isomerase PF00160.16 CCF39859.1 - 9.9e-39 133.0 0.3 1.1e-38 132.8 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Fungal_trans PF04082.13 CCF39860.1 - 0.00011 21.1 0.0 0.00018 20.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2537 PF10801.3 CCF39861.1 - 0.019 15.0 1.1 0.023 14.7 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2537) SBF PF01758.11 CCF39861.1 - 0.075 12.4 0.9 0.12 11.7 0.6 1.3 1 0 0 1 1 1 0 Sodium Bile acid symporter family FMN_dh PF01070.13 CCF39862.1 - 7.3e-98 327.6 1.5 1.4e-96 323.4 1.0 1.9 1 1 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.12 CCF39862.1 - 7e-07 28.4 0.2 1.1e-06 27.8 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.20 CCF39862.1 - 3.8e-06 26.0 0.4 0.00095 18.1 0.1 2.1 2 0 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain ThiG PF05690.9 CCF39862.1 - 0.0022 17.1 0.3 0.54 9.2 0.1 2.6 2 1 0 3 3 3 2 Thiazole biosynthesis protein ThiG His_biosynth PF00977.16 CCF39862.1 - 0.028 13.6 0.1 0.062 12.5 0.1 1.6 2 0 0 2 2 2 0 Histidine biosynthesis protein NMO PF03060.10 CCF39862.1 - 0.029 13.5 0.7 0.052 12.6 0.5 1.4 1 0 0 1 1 1 0 Nitronate monooxygenase Lipase_3 PF01764.20 CCF39863.1 - 1.7e-13 50.3 0.0 1e-12 47.8 0.0 2.1 1 1 0 1 1 1 1 Lipase (class 3) NAD_binding_8 PF13450.1 CCF39864.1 - 3.5e-09 36.5 0.1 8.5e-09 35.3 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 CCF39864.1 - 1.5e-05 24.2 0.0 6.4e-05 22.2 0.0 1.9 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.1 CCF39864.1 - 0.0034 17.4 1.0 0.0072 16.4 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CCF39864.1 - 0.011 15.6 0.3 0.05 13.4 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 CCF39864.1 - 0.014 14.4 0.1 0.021 13.9 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain DUF1344 PF07076.6 CCF39864.1 - 0.018 14.6 0.2 0.036 13.6 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) HI0933_like PF03486.9 CCF39864.1 - 0.035 12.5 0.1 0.054 11.9 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_9 PF13454.1 CCF39864.1 - 0.088 12.5 0.5 1.1 8.9 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding Thi4 PF01946.12 CCF39864.1 - 0.094 11.7 0.1 0.19 10.7 0.1 1.5 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.19 CCF39864.1 - 0.098 11.4 0.2 0.15 10.8 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.19 CCF39864.1 - 0.15 10.9 0.0 0.25 10.1 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 CCF39864.1 - 0.16 10.8 0.9 0.4 9.5 0.1 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein 6PF2K PF01591.13 CCF39865.1 - 6e-64 215.1 0.0 5e-46 156.5 0.0 2.2 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 CCF39865.1 - 4.6e-26 91.7 0.1 4.3e-25 88.6 0.0 2.4 2 1 1 3 3 3 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 CCF39865.1 - 1.4e-05 24.9 0.0 5.3e-05 23.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain CARD PF00619.16 CCF39865.1 - 0.0099 15.6 0.6 0.046 13.5 0.4 2.0 1 1 0 1 1 1 1 Caspase recruitment domain AAA_17 PF13207.1 CCF39865.1 - 0.04 14.7 0.0 0.16 12.8 0.0 2.2 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.5 CCF39865.1 - 0.057 12.6 0.0 0.095 11.8 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Zeta_toxin PF06414.7 CCF39865.1 - 0.16 11.0 0.0 0.78 8.8 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin Decorin_bind PF02352.10 CCF39865.1 - 0.19 11.7 0.0 0.35 10.8 0.0 1.3 1 0 0 1 1 1 0 Decorin binding protein Gaa1 PF04114.9 CCF39866.1 - 7e-73 246.0 9.7 4.6e-61 207.0 0.0 2.6 1 1 1 2 2 2 2 Gaa1-like, GPI transamidase component Rhomboid PF01694.17 CCF39867.1 - 7.1e-14 52.0 10.9 9.2e-14 51.6 7.6 1.1 1 0 0 1 1 1 1 Rhomboid family C_GCAxxG_C_C PF09719.5 CCF39867.1 - 0.07 12.9 0.0 0.17 11.6 0.0 1.6 2 0 0 2 2 2 0 Putative redox-active protein (C_GCAxxG_C_C) 5TM-5TMR_LYT PF07694.7 CCF39867.1 - 1.1 8.5 8.3 2.4 7.4 5.1 1.9 1 1 1 2 2 2 0 5TMR of 5TMR-LYT Glyco_hydro_10 PF00331.15 CCF39869.1 - 2e-97 326.1 0.0 2.2e-97 325.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Cellulase-like PF12876.2 CCF39869.1 - 0.036 14.5 0.0 0.1 13.0 0.0 1.8 1 0 0 1 1 1 0 Sugar-binding cellulase-like Ribosomal_60s PF00428.14 CCF39871.1 - 7e-26 90.4 10.8 8.5e-26 90.1 7.5 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein UBA PF00627.26 CCF39872.1 - 6.9e-06 25.7 0.3 2.9e-05 23.7 0.1 2.3 2 0 0 2 2 2 1 UBA/TS-N domain UBX PF00789.15 CCF39872.1 - 0.0011 18.9 0.6 0.0036 17.3 0.0 2.1 2 0 0 2 2 2 1 UBX domain CAF-1_p150 PF11600.3 CCF39872.1 - 0.013 14.9 38.0 0.019 14.3 26.3 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal zf-C2H2 PF00096.21 CCF39872.1 - 0.04 14.2 0.4 0.088 13.1 0.3 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.2 CCF39872.1 - 0.062 13.4 1.2 0.087 12.9 0.2 1.8 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) DUF342 PF03961.8 CCF39872.1 - 0.28 9.5 11.0 0.36 9.1 7.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) SOBP PF15279.1 CCF39872.1 - 1.2 9.4 6.8 1.6 9.0 4.7 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein PLRV_ORF5 PF01690.12 CCF39872.1 - 1.9 7.5 12.7 2.3 7.2 8.8 1.3 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein DUF1423 PF07227.6 CCF39872.1 - 6.8 5.2 18.3 8.9 4.8 12.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1423) APG6 PF04111.7 CCF39872.1 - 7.5 5.4 25.8 12 4.7 17.9 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Ycf1 PF05758.7 CCF39872.1 - 9.3 3.8 13.2 11 3.5 9.1 1.2 1 0 0 1 1 1 0 Ycf1 V_ATPase_I PF01496.14 CCF39872.1 - 9.5 3.9 7.5 11 3.7 5.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Motile_Sperm PF00635.21 CCF39873.1 - 9.2e-25 86.4 2.4 1.6e-24 85.6 0.4 2.3 2 1 1 3 3 3 1 MSP (Major sperm protein) domain FixG_C PF11614.3 CCF39873.1 - 0.053 13.6 0.1 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 IG-like fold at C-terminal of FixG, putative oxidoreductase Spc7 PF08317.6 CCF39873.1 - 0.1 11.2 1.8 0.15 10.7 1.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Golgin_A5 PF09787.4 CCF39873.1 - 0.26 9.7 9.0 0.32 9.4 6.3 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 FA_desaturase PF00487.19 CCF39874.1 - 1.2e-30 106.8 16.8 2e-30 106.1 11.6 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.5 CCF39874.1 - 9.9e-20 69.5 0.1 1.8e-19 68.6 0.1 1.5 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) ICE2 PF08426.5 CCF39875.1 - 9e-27 93.7 0.4 1e-26 93.5 0.3 1.0 1 0 0 1 1 1 1 ICE2 ABC2_membrane_5 PF13346.1 CCF39875.1 - 0.092 12.0 3.0 0.11 11.7 2.0 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Disaggr_repeat PF06848.6 CCF39876.1 - 0.13 11.6 0.0 2 7.7 0.0 2.1 2 0 0 2 2 2 0 Disaggregatase related repeat SMC_N PF02463.14 CCF39878.1 - 4.2e-06 26.1 10.8 7.8e-06 25.2 7.5 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain BLOC1_2 PF10046.4 CCF39878.1 - 0.023 14.8 0.2 0.023 14.8 0.1 3.8 3 2 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF904 PF06005.7 CCF39878.1 - 0.046 14.0 1.6 0.046 14.0 1.1 4.8 4 1 0 4 4 4 0 Protein of unknown function (DUF904) NPV_P10 PF05531.7 CCF39878.1 - 0.048 13.9 8.3 0.19 11.9 0.0 4.0 3 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein CENP-F_leu_zip PF10473.4 CCF39878.1 - 0.4 10.5 35.2 0.66 9.8 1.5 4.1 1 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MCC-bdg_PDZ PF10506.4 CCF39878.1 - 1.9 8.3 20.6 1.3 8.8 1.5 4.3 4 0 0 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome APG6 PF04111.7 CCF39878.1 - 2.2 7.2 31.1 0.088 11.8 6.8 2.5 1 1 0 2 2 2 0 Autophagy protein Apg6 Na_Ca_ex PF01699.19 CCF39879.1 - 1.8e-44 150.7 29.8 7.3e-23 80.7 7.6 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Golgin_A5 PF09787.4 CCF39879.1 - 0.68 8.3 1.9 1.2 7.5 1.3 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 Swi5 PF07061.6 CCF39882.1 - 5.6e-20 70.9 0.0 5.8e-20 70.8 0.0 1.0 1 0 0 1 1 1 1 Swi5 AdoMet_Synthase PF01941.14 CCF39882.1 - 0.13 10.7 0.1 0.13 10.7 0.1 1.0 1 0 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) DUF3391 PF11871.3 CCF39882.1 - 0.14 12.3 0.3 0.15 12.3 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) Lactamase_B_3 PF13483.1 CCF39883.1 - 8.3e-06 25.5 0.0 1.3e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.2 CCF39883.1 - 0.00064 19.3 0.5 0.0015 18.1 0.1 1.8 2 0 0 2 2 2 1 Beta-lactamase superfamily domain UIM PF02809.15 CCF39884.1 - 0.081 12.5 2.6 0.17 11.5 1.8 1.5 1 0 0 1 1 1 0 Ubiquitin interaction motif ABC_membrane PF00664.18 CCF39885.1 - 0.018 14.4 0.5 0.022 14.1 0.3 1.1 1 0 0 1 1 1 0 ABC transporter transmembrane region NAD_binding_6 PF08030.7 CCF39889.1 - 3.9e-32 111.3 0.0 8.3e-32 110.2 0.0 1.5 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 CCF39889.1 - 4.4e-20 71.5 1.0 8.8e-20 70.5 0.0 2.0 3 0 0 3 3 3 1 FAD-binding domain Ferric_reduct PF01794.14 CCF39889.1 - 0.00011 22.3 1.5 0.0002 21.4 1.0 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.19 CCF39889.1 - 0.0014 18.7 0.0 0.003 17.6 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Fungal_trans_2 PF11951.3 CCF39890.1 - 5.9e-09 35.0 0.3 8e-09 34.5 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain ABC_tran PF00005.22 CCF39891.1 - 8e-15 55.3 0.0 9.9e-15 55.0 0.0 1.0 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.1 CCF39891.1 - 0.0001 21.7 0.3 0.00015 21.1 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.1 CCF39891.1 - 0.00051 20.1 0.1 0.00058 19.9 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CCF39891.1 - 0.0013 19.5 0.3 0.0017 19.1 0.2 1.3 1 1 0 1 1 1 1 AAA domain PRK PF00485.13 CCF39891.1 - 0.0018 17.8 0.3 0.011 15.2 0.2 1.9 1 1 1 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.1 CCF39891.1 - 0.0047 16.8 0.0 0.0058 16.5 0.0 1.3 1 1 0 1 1 1 1 AAA domain CbiA PF01656.18 CCF39891.1 - 0.0066 15.8 0.0 0.007 15.7 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain FtsK_SpoIIIE PF01580.13 CCF39891.1 - 0.0073 15.7 1.0 0.01 15.3 0.7 1.6 1 1 0 1 1 1 1 FtsK/SpoIIIE family AAA_25 PF13481.1 CCF39891.1 - 0.0099 15.3 0.2 0.016 14.5 0.1 1.5 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 CCF39891.1 - 0.015 14.7 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_16 PF13191.1 CCF39891.1 - 0.016 15.2 0.3 0.016 15.1 0.2 1.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.1 CCF39891.1 - 0.018 15.3 1.3 0.018 15.3 0.9 1.3 1 1 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.4 CCF39891.1 - 0.02 13.5 0.1 0.032 12.8 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain DUF258 PF03193.11 CCF39891.1 - 0.025 13.7 0.5 0.024 13.8 0.3 1.3 1 1 0 1 1 1 0 Protein of unknown function, DUF258 T2SE PF00437.15 CCF39891.1 - 0.043 12.7 0.1 0.081 11.8 0.0 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein MMR_HSR1 PF01926.18 CCF39891.1 - 0.052 13.5 0.2 0.062 13.2 0.2 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.1 CCF39891.1 - 0.06 13.4 0.4 0.069 13.2 0.3 1.5 1 1 0 1 1 1 0 AAA domain Hpr_kinase_C PF07475.7 CCF39891.1 - 0.068 12.4 0.3 0.093 12.0 0.2 1.2 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain ArgK PF03308.11 CCF39891.1 - 0.07 11.9 0.2 0.07 11.9 0.2 1.6 2 0 0 2 2 2 0 ArgK protein AAA_23 PF13476.1 CCF39891.1 - 0.084 13.1 0.1 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 CCF39891.1 - 0.11 12.2 0.5 0.14 11.8 0.1 1.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ATP-synt_ab PF00006.20 CCF39891.1 - 0.12 11.8 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain cobW PF02492.14 CCF39891.1 - 0.14 11.6 1.2 0.26 10.7 0.4 1.7 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Miro PF08477.8 CCF39891.1 - 0.14 12.6 0.1 0.23 11.9 0.1 1.5 1 0 0 1 1 1 0 Miro-like protein APS_kinase PF01583.15 CCF39891.1 - 0.17 11.5 0.4 0.32 10.6 0.2 1.5 1 1 0 1 1 1 0 Adenylylsulphate kinase Dynamin_N PF00350.18 CCF39891.1 - 0.18 11.6 1.1 0.18 11.6 0.8 1.4 1 1 0 1 1 1 0 Dynamin family NAD_binding_4 PF07993.7 CCF39892.1 - 7.2e-34 116.8 0.0 1e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.16 CCF39892.1 - 6.2e-12 45.4 0.0 8.9e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 CCF39892.1 - 0.00068 18.6 0.0 0.075 11.9 0.0 2.6 2 1 0 2 2 2 1 RmlD substrate binding domain PRAI PF00697.17 CCF39892.1 - 0.03 13.8 0.0 0.087 12.3 0.0 1.7 2 0 0 2 2 2 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase adh_short PF00106.20 CCF39892.1 - 0.031 14.2 0.0 0.16 11.8 0.0 2.0 1 1 0 1 1 1 0 short chain dehydrogenase YecR PF13992.1 CCF39892.1 - 0.05 13.7 0.0 0.092 12.9 0.0 1.4 1 0 0 1 1 1 0 YecR-like lipoprotein Polysacc_synt_2 PF02719.10 CCF39892.1 - 0.053 12.4 0.0 0.23 10.3 0.0 1.9 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein tRNA-synt_2b PF00587.20 CCF39893.1 - 7.5e-44 149.3 0.1 1.2e-43 148.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 CCF39893.1 - 2.4e-20 72.2 0.2 4.7e-20 71.3 0.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.9 CCF39893.1 - 3.8e-11 42.6 0.0 8.9e-11 41.5 0.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.16 CCF39893.1 - 9.2e-11 41.4 0.0 1.8e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 TGS domain CDP-OH_P_transf PF01066.16 CCF39894.1 - 1.6e-12 47.5 1.0 1.6e-12 47.5 0.7 1.7 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase FAD_binding_3 PF01494.14 CCF39896.1 - 1.5e-25 90.0 0.1 8e-15 54.7 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 CCF39896.1 - 8.2e-05 21.6 0.7 0.22 10.3 0.3 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Trp_halogenase PF04820.9 CCF39896.1 - 0.0023 16.6 0.6 0.068 11.7 0.0 2.3 2 0 0 2 2 2 1 Tryptophan halogenase Pyr_redox PF00070.22 CCF39896.1 - 0.0051 17.1 2.8 0.08 13.3 0.3 3.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF39896.1 - 0.02 13.8 1.2 0.5 9.2 0.8 2.2 1 1 0 1 1 1 0 Lycopene cyclase protein NAD_binding_8 PF13450.1 CCF39896.1 - 0.046 13.7 0.2 0.1 12.6 0.2 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 CCF39896.1 - 0.059 12.4 1.2 1.2 8.1 0.1 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase FixQ PF05545.6 CCF39896.1 - 0.12 11.9 0.2 0.32 10.6 0.1 1.7 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Phage_int_SAM_5 PF13102.1 CCF39897.1 - 0.076 13.0 0.5 0.12 12.3 0.3 1.3 1 0 0 1 1 1 0 Phage integrase SAM-like domain Cpn60_TCP1 PF00118.19 CCF39898.1 - 3.4e-145 484.4 11.1 3.8e-145 484.2 7.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CRT10 PF08728.5 CCF39901.1 - 0.15 10.0 0.0 0.37 8.7 0.0 1.5 2 0 0 2 2 2 0 CRT10 YCII PF03795.9 CCF39902.1 - 1e-08 35.2 0.0 1.3e-08 34.8 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain DUF2408 PF10303.4 CCF39903.1 - 2.3e-45 153.9 1.3 1.5e-29 102.8 0.0 4.0 2 2 2 4 4 4 3 Protein of unknown function (DUF2408) Blo-t-5 PF11642.3 CCF39903.1 - 0.074 12.8 1.2 0.66 9.7 0.1 2.8 2 1 1 3 3 3 0 Mite allergen Blo t 5 DUF1128 PF06569.6 CCF39903.1 - 0.11 12.2 0.7 5.4 6.8 0.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1128) Tropomyosin_1 PF12718.2 CCF39903.1 - 0.12 12.2 2.0 0.26 11.1 1.4 1.5 1 0 0 1 1 1 0 Tropomyosin like ING PF12998.2 CCF39903.1 - 0.16 12.2 2.3 11 6.2 0.1 3.2 3 1 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding Laminin_II PF06009.7 CCF39903.1 - 0.25 11.1 2.9 0.51 10.0 0.6 2.3 1 1 1 2 2 2 0 Laminin Domain II Wbp11 PF09429.5 CCF39903.1 - 0.32 10.9 3.4 5.3 7.0 0.0 3.4 4 0 0 4 4 4 0 WW domain binding protein 11 Prefoldin_2 PF01920.15 CCF39903.1 - 0.36 10.6 3.9 5.4 6.8 0.1 2.9 2 1 0 2 2 2 0 Prefoldin subunit IncA PF04156.9 CCF39903.1 - 5.7 6.4 9.2 22 4.5 5.9 2.1 1 1 1 2 2 2 0 IncA protein zf-Tim10_DDP PF02953.10 CCF39904.1 - 1.7e-22 78.4 1.9 2.2e-22 78.1 1.3 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger CorA PF01544.13 CCF39905.1 - 1.5e-43 148.9 0.0 2e-43 148.4 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein MFS_1 PF07690.11 CCF39906.1 - 4.2e-30 104.6 31.1 4.2e-30 104.6 21.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF39906.1 - 3.8e-13 48.8 11.7 7.4e-13 47.8 7.8 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter BTB_2 PF02214.17 CCF39907.1 - 9.5e-05 22.5 0.0 0.00023 21.3 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain SNARE PF05739.14 CCF39909.1 - 0.035 13.7 0.2 5.9 6.6 0.0 2.3 2 0 0 2 2 2 0 SNARE domain XPG_I PF00867.13 CCF39910.1 - 1.1e-26 92.6 0.0 3e-26 91.3 0.0 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 CCF39910.1 - 3.3e-05 24.0 0.0 7.4e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.2 CCF39910.1 - 0.13 11.7 0.0 0.31 10.4 0.0 1.6 1 0 0 1 1 1 0 XPG domain containing Dicty_REP PF05086.7 CCF39910.1 - 1.2 6.7 5.2 1.7 6.2 3.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Peptidase_C48 PF02902.14 CCF39911.1 - 2.9e-17 63.0 0.0 4.9e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Glyco_hydro_61 PF03443.9 CCF39912.1 - 2.1e-12 47.3 0.0 2.4e-12 47.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 tRNA-synt_2b PF00587.20 CCF39916.1 - 7.8e-36 123.2 0.0 1.1e-35 122.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 CCF39916.1 - 3.8e-09 36.3 0.0 1.1e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 Anticodon binding domain Prefoldin PF02996.12 CCF39917.1 - 2.1e-25 88.6 0.8 2.9e-25 88.2 0.5 1.2 1 0 0 1 1 1 1 Prefoldin subunit Sec2p PF06428.6 CCF39917.1 - 0.012 15.4 7.7 0.056 13.3 0.4 2.3 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p Prefoldin_2 PF01920.15 CCF39917.1 - 0.017 14.9 6.3 0.45 10.3 0.2 2.1 2 0 0 2 2 2 0 Prefoldin subunit DUF1539 PF07560.6 CCF39917.1 - 0.039 13.8 0.6 1.5 8.6 0.4 2.1 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1539) Cep57_MT_bd PF06657.8 CCF39917.1 - 0.049 13.5 0.8 0.049 13.5 0.6 1.9 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Spc7 PF08317.6 CCF39917.1 - 0.07 11.7 3.7 0.14 10.7 2.5 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein PXB PF12828.2 CCF39917.1 - 0.087 12.4 3.5 0.46 10.0 2.5 2.0 1 1 0 1 1 1 0 PX-associated UPF0449 PF15136.1 CCF39917.1 - 0.1 12.8 3.7 1.6 8.9 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 XkdW PF09636.5 CCF39917.1 - 0.14 11.9 0.9 0.43 10.4 0.3 1.8 2 0 0 2 2 2 0 XkdW protein CENP-Q PF13094.1 CCF39917.1 - 0.18 11.8 6.4 1.2 9.1 0.8 2.1 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit CCDC155 PF14662.1 CCF39917.1 - 0.23 11.0 7.5 0.079 12.5 0.7 2.1 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 DUF904 PF06005.7 CCF39917.1 - 0.27 11.5 7.0 4.7 7.5 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF904) Fzo_mitofusin PF04799.8 CCF39917.1 - 0.32 10.3 4.1 1 8.6 0.3 2.1 2 0 0 2 2 2 0 fzo-like conserved region DUF3461 PF11944.3 CCF39917.1 - 0.48 10.2 3.2 6 6.7 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3461) Fib_alpha PF08702.5 CCF39917.1 - 0.58 10.2 3.9 9.4 6.3 0.5 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family SNF2_N PF00176.18 CCF39919.1 - 1.3e-05 24.1 0.0 1.5e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CCF39920.1 - 7.7e-13 48.1 0.0 9.3e-13 47.8 0.0 1.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AA_permease PF00324.16 CCF39921.1 - 1e-63 215.3 13.2 1.5e-63 214.8 9.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF39921.1 - 1.8e-17 63.0 15.8 2.4e-17 62.6 10.9 1.1 1 0 0 1 1 1 1 Amino acid permease Endonuclease_NS PF01223.18 CCF39923.1 - 1e-59 201.6 0.0 1.3e-59 201.3 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease WD40 PF00400.27 CCF39924.1 - 1.5e-14 53.2 7.2 1.6e-08 34.0 0.7 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat bZIP_2 PF07716.10 CCF39925.1 - 0.0028 17.4 12.9 0.0045 16.7 9.0 1.3 1 0 0 1 1 1 1 Basic region leucine zipper EMP24_GP25L PF01105.19 CCF39925.1 - 0.22 11.2 0.7 0.32 10.7 0.5 1.1 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD bZIP_1 PF00170.16 CCF39925.1 - 2.6 8.0 14.8 7.4 6.6 10.2 1.7 1 1 0 1 1 1 0 bZIP transcription factor DivIC PF04977.10 CCF39925.1 - 5.3 6.6 5.6 8.7 5.9 3.5 1.5 1 1 0 1 1 1 0 Septum formation initiator Cellulase PF00150.13 CCF39926.1 - 1.6e-21 76.8 1.8 2.1e-21 76.3 1.2 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.13 CCF39926.1 - 4.5e-12 45.4 11.2 2.2e-11 43.1 7.7 2.3 1 0 0 1 1 1 1 Fungal cellulose binding domain Glyco_hydro_2_C PF02836.12 CCF39926.1 - 8.4e-05 21.6 0.0 0.00018 20.5 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Cellulase-like PF12876.2 CCF39926.1 - 0.00039 20.8 0.0 0.00097 19.5 0.0 1.7 1 0 0 1 1 1 1 Sugar-binding cellulase-like Glyco_hydro_42 PF02449.10 CCF39926.1 - 0.00042 19.5 0.3 0.00097 18.3 0.2 1.5 2 0 0 2 2 2 1 Beta-galactosidase Glyco_hydro_10 PF00331.15 CCF39926.1 - 0.018 14.0 0.1 0.033 13.2 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 MGC-24 PF05283.6 CCF39926.1 - 0.03 14.1 9.2 0.074 12.8 6.4 1.6 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) Toxin_7 PF05980.7 CCF39926.1 - 1.8 8.6 7.4 0.27 11.3 1.8 2.2 2 0 0 2 2 2 0 Toxin 7 LysM PF01476.15 CCF39927.1 - 1.6e-13 50.3 0.1 2.6e-13 49.6 0.1 1.4 1 0 0 1 1 1 1 LysM domain GAF PF01590.21 CCF39927.1 - 0.15 12.2 0.0 0.27 11.3 0.0 1.4 1 1 0 1 1 1 0 GAF domain ExoD PF06055.7 CCF39928.1 - 0.13 11.3 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Exopolysaccharide synthesis, ExoD SOBP PF15279.1 CCF39929.1 - 3.4 7.9 21.9 4.4 7.5 15.1 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Mitofilin PF09731.4 CCF39929.1 - 5.2 5.6 15.5 6.8 5.2 10.8 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Pyr_redox_3 PF13738.1 CCF39930.1 - 7.1e-19 68.6 0.0 5.4e-18 65.7 0.0 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 CCF39930.1 - 2.7e-14 52.2 0.1 9.5e-11 40.5 0.1 2.8 2 2 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 CCF39930.1 - 8.1e-10 38.5 0.0 1.7e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 CCF39930.1 - 5e-05 22.3 0.0 0.05 12.5 0.0 3.0 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 CCF39930.1 - 6.5e-05 22.7 0.0 0.00059 19.6 0.0 2.5 3 0 0 3 3 3 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.7 CCF39930.1 - 0.092 11.6 0.0 0.43 9.4 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein Shikimate_DH PF01488.15 CCF39930.1 - 0.14 12.2 0.0 32 4.6 0.0 3.4 4 0 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase KAAG1 PF15354.1 CCF39931.1 - 0.091 13.1 0.5 0.29 11.4 0.2 1.8 1 1 1 2 2 2 0 Kidney-associated antigen 1 Aldedh PF00171.17 CCF39935.1 - 2.1e-166 553.8 0.5 2.4e-166 553.6 0.4 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family adh_short PF00106.20 CCF39936.1 - 1.9e-19 70.1 0.2 4.3e-19 69.0 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase Fungal_trans_2 PF11951.3 CCF39936.1 - 3.8e-19 68.5 0.1 2.2e-18 66.0 0.0 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain adh_short_C2 PF13561.1 CCF39936.1 - 4.2e-18 66.0 0.0 6.3e-18 65.4 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Zn_clus PF00172.13 CCF39936.1 - 5.8e-08 32.5 13.3 1e-07 31.6 8.0 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF39936.1 - 0.00089 18.2 0.1 0.0016 17.3 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain KR PF08659.5 CCF39936.1 - 0.0016 18.1 0.0 0.0036 16.9 0.0 1.5 1 0 0 1 1 1 1 KR domain HTH_psq PF05225.11 CCF39937.1 - 7.1e-15 54.2 0.2 1.2e-14 53.5 0.2 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF39937.1 - 1.2e-12 47.4 0.1 4.7e-12 45.5 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.1 CCF39937.1 - 3.5e-05 23.2 0.1 0.00013 21.5 0.0 1.9 1 1 1 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 CCF39937.1 - 0.00017 21.4 0.2 0.00044 20.1 0.0 1.8 2 0 0 2 2 1 1 Helix-turn-helix domain HTH_7 PF02796.10 CCF39937.1 - 0.00036 20.3 0.1 0.00069 19.4 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.1 CCF39937.1 - 0.001 18.5 0.0 0.0029 17.1 0.0 1.7 2 1 0 2 2 2 1 PucR C-terminal helix-turn-helix domain HTH_1 PF00126.22 CCF39937.1 - 0.012 15.3 0.4 0.028 14.1 0.2 1.7 1 1 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family SpoIIID PF12116.3 CCF39937.1 - 0.028 14.3 0.0 0.051 13.5 0.0 1.5 1 0 0 1 1 1 0 Stage III sporulation protein D HTH_8 PF02954.14 CCF39937.1 - 0.034 13.7 0.8 0.32 10.5 0.1 2.6 1 1 1 2 2 2 0 Bacterial regulatory protein, Fis family CENP-B_N PF04218.8 CCF39937.1 - 0.041 13.3 0.0 0.07 12.5 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_Tnp_1 PF01527.15 CCF39937.1 - 0.053 13.4 0.5 0.16 11.9 0.3 1.9 1 1 0 1 1 1 0 Transposase DUF4164 PF13747.1 CCF39937.1 - 0.079 13.1 0.1 0.13 12.4 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) GSP_synth PF03738.9 CCF39939.1 - 7.8e-21 74.1 0.0 1.4e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 Glutathionylspermidine synthase preATP-grasp CRAL_TRIO PF00650.15 CCF39940.1 - 3.6e-42 143.5 0.0 6.4e-42 142.7 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 CCF39940.1 - 1.6e-16 60.1 0.0 5.7e-16 58.3 0.0 2.0 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 CCF39940.1 - 3.6e-10 39.9 0.0 6.7e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain HIT PF01230.18 CCF39941.1 - 2.7e-13 50.2 0.5 4.2e-13 49.6 0.4 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 CCF39941.1 - 0.0017 18.5 0.4 0.0025 18.0 0.1 1.4 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding CSTF2_hinge PF14327.1 CCF39941.1 - 0.069 13.2 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Hinge domain of cleavage stimulation factor subunit 2 CN_hydrolase PF00795.17 CCF39943.1 - 2.2e-21 76.0 0.0 3.5e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase OPT PF03169.10 CCF39944.1 - 3.1e-103 346.3 30.6 3.5e-103 346.1 21.2 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein AA_permease PF00324.16 CCF39945.1 - 1.2e-81 274.5 30.7 1.3e-81 274.3 21.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF39945.1 - 3.3e-34 118.1 32.3 3.9e-34 117.9 22.4 1.0 1 0 0 1 1 1 1 Amino acid permease Spore_permease PF03845.8 CCF39945.1 - 0.25 9.9 17.3 0.49 9.0 10.0 2.3 2 1 0 2 2 2 0 Spore germination protein ABC2_membrane PF01061.19 CCF39947.1 - 8.3e-41 139.4 28.4 8.3e-41 139.4 19.7 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 CCF39947.1 - 2.7e-10 39.8 13.6 2.7e-10 39.8 9.5 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein PDR_CDR PF06422.7 CCF39947.1 - 0.0022 17.6 1.1 0.0022 17.6 0.8 2.1 3 0 0 3 3 3 1 CDR ABC transporter Aldolase_II PF00596.16 CCF39948.1 - 1.3e-49 168.3 0.3 1.7e-49 167.9 0.2 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain CTP_transf_1 PF01148.15 CCF39949.1 - 3.5e-30 105.5 0.6 3.9e-30 105.3 0.4 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family Exo_endo_phos PF03372.18 CCF39953.1 - 1.5e-12 48.0 0.1 2.7e-12 47.1 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 CCF39953.1 - 0.0016 18.0 0.0 0.16 11.6 0.0 3.0 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase Thioredoxin PF00085.15 CCF39954.1 - 3.2e-27 94.2 0.1 6.6e-27 93.2 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin PITH PF06201.8 CCF39954.1 - 3.7e-10 39.7 0.5 7.5e-10 38.7 0.4 1.6 1 1 0 1 1 1 1 PITH domain Thioredoxin_8 PF13905.1 CCF39954.1 - 5.7e-06 26.3 0.0 1.2e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 CCF39954.1 - 7.2e-06 26.1 0.3 3.2e-05 24.0 0.1 2.1 2 1 0 2 2 2 1 Thioredoxin-like domain AhpC-TSA PF00578.16 CCF39954.1 - 9e-05 22.1 0.2 0.00029 20.5 0.0 1.9 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.5 CCF39954.1 - 0.0003 20.3 0.1 0.00055 19.4 0.0 1.4 1 0 0 1 1 1 1 Redoxin Thioredoxin_9 PF14595.1 CCF39954.1 - 0.0046 16.5 0.0 0.0092 15.5 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 CCF39954.1 - 0.0059 16.6 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like O-FucT PF10250.4 CCF39955.1 - 1e-08 34.6 0.0 2e-05 23.8 0.0 3.1 2 1 0 2 2 2 2 GDP-fucose protein O-fucosyltransferase HET PF06985.6 CCF39956.1 - 1.8e-06 28.1 0.0 2e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) PSII PF00421.14 CCF39956.1 - 0.018 13.6 0.0 0.02 13.4 0.0 1.0 1 0 0 1 1 1 0 Photosystem II protein IZUMO PF15005.1 CCF39957.1 - 0.051 13.6 2.4 0.058 13.4 1.7 1.1 1 0 0 1 1 1 0 Izumo sperm-egg fusion Opy2 PF09463.5 CCF39957.1 - 5.4 7.1 10.0 21 5.2 3.0 2.5 2 1 0 2 2 2 0 Opy2 protein DDE_1 PF03184.14 CCF39958.1 - 6.1e-28 97.4 0.0 7.3e-27 93.9 0.0 2.2 1 1 1 2 2 2 1 DDE superfamily endonuclease HTH_psq PF05225.11 CCF39958.1 - 2.2e-12 46.2 0.0 4.1e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF39958.1 - 5.1e-09 35.8 0.0 1.4e-08 34.3 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.1 CCF39958.1 - 0.0036 16.8 1.0 0.013 15.1 0.0 2.4 3 0 0 3 3 3 1 Homeodomain-like domain CBM-like PF14683.1 CCF39959.1 - 2.1e-12 47.0 0.7 4.2e-12 46.0 0.5 1.5 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.1 CCF39959.1 - 1.5e-09 37.8 0.2 7e-09 35.6 0.0 2.2 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.1 CCF39959.1 - 0.071 13.1 0.0 0.28 11.2 0.0 2.0 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain Pkinase PF00069.20 CCF39961.1 - 1.1e-10 41.1 0.0 2.4e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain DUF908 PF06012.7 CCF39962.1 - 5.9e-87 292.0 0.4 8.4e-87 291.5 0.3 1.2 1 0 0 1 1 1 1 Domain of Unknown Function (DUF908) MFS_1 PF07690.11 CCF39963.1 - 2.7e-14 52.6 25.8 3.1e-14 52.4 17.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1228 PF06779.9 CCF39963.1 - 9.8e-06 25.5 0.3 9.8e-06 25.5 0.2 3.2 3 1 0 3 3 3 1 Protein of unknown function (DUF1228) CDC73 PF05179.9 CCF39964.1 - 6.2e-42 143.8 0.0 9.7e-42 143.1 0.0 1.3 1 1 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family AMP-binding PF00501.23 CCF39966.1 - 1.7e-61 207.8 0.2 2.6e-61 207.2 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.20 CCF39966.1 - 1.9e-12 47.2 0.0 3.8e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site Condensation PF00668.15 CCF39966.1 - 7.3e-12 44.7 0.0 1e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 Condensation domain PD-C2-AF1 PF09310.5 CCF39966.1 - 0.00037 19.7 0.1 0.00072 18.8 0.1 1.4 1 0 0 1 1 1 1 POU domain, class 2, associating factor 1 AMP-binding_C PF13193.1 CCF39966.1 - 0.026 15.4 0.1 0.13 13.1 0.0 2.3 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain ABC2_membrane PF01061.19 CCF39967.1 - 3.8e-69 232.0 52.7 4.3e-36 124.0 14.2 3.5 3 1 1 4 4 4 3 ABC-2 type transporter PDR_CDR PF06422.7 CCF39967.1 - 2.5e-27 94.5 0.6 1e-26 92.5 0.0 2.4 2 0 0 2 2 1 1 CDR ABC transporter ABC_tran PF00005.22 CCF39967.1 - 2.3e-15 57.0 0.0 3.9e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter cobW PF02492.14 CCF39967.1 - 0.00012 21.5 0.3 0.0002 20.8 0.2 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain DUF258 PF03193.11 CCF39967.1 - 0.00014 21.0 0.0 0.00024 20.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_21 PF13304.1 CCF39967.1 - 0.00046 20.2 0.1 0.37 10.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CCF39967.1 - 0.0025 17.8 0.6 0.0064 16.4 0.4 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.1 CCF39967.1 - 0.0031 17.4 0.6 0.0084 16.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain UPF0079 PF02367.12 CCF39967.1 - 0.0072 15.9 0.3 0.015 14.9 0.2 1.4 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 AAA_29 PF13555.1 CCF39967.1 - 0.0089 15.5 0.2 0.022 14.2 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.1 CCF39967.1 - 0.0099 16.0 0.2 0.023 14.8 0.2 1.7 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 CCF39967.1 - 0.013 14.7 0.0 0.18 11.0 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_33 PF13671.1 CCF39967.1 - 0.018 14.9 0.0 0.035 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 CCF39967.1 - 0.029 14.3 0.1 0.065 13.2 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_17 PF13207.1 CCF39967.1 - 0.033 14.9 0.0 0.069 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 CCF39967.1 - 0.037 13.4 0.0 0.2 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 CCF39967.1 - 0.042 13.4 0.3 0.09 12.4 0.2 1.5 1 0 0 1 1 1 0 NACHT domain RecA PF00154.16 CCF39967.1 - 0.07 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein Miro PF08477.8 CCF39967.1 - 0.077 13.4 0.0 0.3 11.5 0.0 2.0 2 0 0 2 2 2 0 Miro-like protein Zeta_toxin PF06414.7 CCF39967.1 - 0.13 11.3 0.4 0.23 10.5 0.3 1.3 1 0 0 1 1 1 0 Zeta toxin PduV-EutP PF10662.4 CCF39967.1 - 0.13 11.7 0.4 0.24 10.8 0.3 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.1 CCF39967.1 - 0.17 12.1 0.0 0.33 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 CCF39967.1 - 0.19 10.5 0.3 0.32 9.7 0.2 1.2 1 0 0 1 1 1 0 NB-ARC domain PRK PF00485.13 CCF39967.1 - 0.21 11.1 0.2 0.36 10.3 0.1 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Septin PF00735.13 CCF39967.1 - 0.24 10.3 0.3 0.83 8.6 0.1 1.8 2 0 0 2 2 2 0 Septin AAA_15 PF13175.1 CCF39967.1 - 0.27 10.2 0.0 7.9 5.3 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain IGPS PF00218.16 CCF39969.1 - 2.2e-95 318.5 0.0 3.4e-95 317.9 0.0 1.3 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase PRAI PF00697.17 CCF39969.1 - 4.4e-50 169.9 0.0 1e-46 158.9 0.0 2.5 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.23 CCF39969.1 - 1.5e-05 24.5 0.0 3.3e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NanE PF04131.9 CCF39969.1 - 0.01 14.8 0.1 0.53 9.2 0.0 2.9 3 0 0 3 3 3 0 Putative N-acetylmannosamine-6-phosphate epimerase QRPTase_C PF01729.14 CCF39969.1 - 0.018 14.5 0.5 0.73 9.3 0.1 2.8 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain FMN_dh PF01070.13 CCF39969.1 - 0.027 13.3 0.0 0.12 11.1 0.0 2.1 2 0 0 2 2 2 0 FMN-dependent dehydrogenase His_biosynth PF00977.16 CCF39969.1 - 0.036 13.3 0.1 0.21 10.8 0.0 2.3 3 0 0 3 3 3 0 Histidine biosynthesis protein BRCT PF00533.21 CCF39970.1 - 0.0004 20.4 0.1 0.001 19.1 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 CCF39970.1 - 0.001 18.8 0.3 0.0027 17.5 0.2 1.7 1 1 0 1 1 1 1 twin BRCT domain Rep_fac_C PF08542.6 CCF39972.1 - 7.2e-24 83.5 0.1 1.7e-23 82.3 0.1 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 CCF39972.1 - 7.9e-12 45.1 0.0 1.5e-11 44.2 0.0 1.5 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.24 CCF39972.1 - 1.2e-06 28.7 0.2 2.9e-06 27.5 0.1 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CCF39972.1 - 2.6e-06 27.6 0.5 9.7e-05 22.5 0.1 2.6 1 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CCF39972.1 - 2.4e-05 24.4 2.2 0.017 15.0 0.6 3.1 2 1 0 2 2 2 1 AAA ATPase domain Sigma54_activ_2 PF14532.1 CCF39972.1 - 0.0033 17.4 0.2 0.16 12.0 0.1 2.4 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_33 PF13671.1 CCF39972.1 - 0.0065 16.3 0.1 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 CCF39972.1 - 0.0084 16.4 0.0 0.018 15.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SNF2_N PF00176.18 CCF39972.1 - 0.028 13.2 0.0 0.033 12.9 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain Rad17 PF03215.10 CCF39972.1 - 0.041 12.5 0.0 0.057 12.0 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Arch_ATPase PF01637.13 CCF39972.1 - 0.052 13.2 0.1 0.17 11.5 0.0 1.9 2 1 0 2 2 2 0 Archaeal ATPase AAA_29 PF13555.1 CCF39972.1 - 0.061 12.8 0.1 0.85 9.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain T4SS-DNA_transf PF02534.9 CCF39972.1 - 0.069 11.7 0.1 0.17 10.4 0.0 1.6 2 0 0 2 2 2 0 Type IV secretory system Conjugative DNA transfer AAA_10 PF12846.2 CCF39972.1 - 0.074 12.4 0.2 2.2 7.6 0.0 2.5 2 1 0 3 3 3 0 AAA-like domain TK PF00265.13 CCF39972.1 - 0.11 12.0 1.0 0.53 9.8 0.6 2.1 2 1 0 2 2 2 0 Thymidine kinase Ribosomal_L16 PF00252.13 CCF39973.1 - 5.6e-30 103.8 0.4 7.8e-30 103.3 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e RFC1 PF08519.7 CCF39974.1 - 3.3e-56 189.3 0.0 8.3e-56 188.0 0.0 1.7 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.21 CCF39974.1 - 2.4e-13 50.0 0.0 5e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.24 CCF39974.1 - 6.5e-09 36.0 0.1 1.7e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 CCF39974.1 - 2.2e-05 23.3 0.0 4.6e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_17 PF13207.1 CCF39974.1 - 3.9e-05 24.4 1.3 0.00028 21.6 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.1 CCF39974.1 - 0.00042 20.4 0.0 0.0022 18.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CCF39974.1 - 0.00091 18.9 0.1 0.0029 17.3 0.1 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 CCF39974.1 - 0.0053 16.7 0.0 0.024 14.6 0.0 2.2 2 0 0 2 2 1 1 AAA ATPase domain DNA_pol3_delta PF06144.8 CCF39974.1 - 0.014 14.8 0.0 0.03 13.8 0.0 1.6 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_18 PF13238.1 CCF39974.1 - 0.014 15.6 2.1 0.023 15.0 0.1 2.5 2 0 0 2 2 1 0 AAA domain PTCB-BRCT PF12738.2 CCF39974.1 - 0.038 13.8 0.0 0.1 12.4 0.0 1.8 1 0 0 1 1 1 0 twin BRCT domain AAA_28 PF13521.1 CCF39974.1 - 0.052 13.5 1.7 0.14 12.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.7 CCF39974.1 - 0.081 11.9 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 CCF39974.1 - 0.081 12.8 0.0 0.23 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain FerA PF08165.6 CCF39974.1 - 0.081 12.5 1.3 9.3 6.0 0.1 2.7 2 0 0 2 2 2 0 FerA (NUC095) domain NTPase_1 PF03266.10 CCF39974.1 - 0.1 12.2 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 NTPase Anophelin PF10731.4 CCF39975.1 - 0.012 15.6 1.5 0.034 14.2 1.0 1.8 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito LRR19-TM PF15176.1 CCF39975.1 - 0.034 13.8 0.7 0.051 13.2 0.5 1.3 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DUF1143 PF06608.6 CCF39975.1 - 0.061 13.3 0.1 0.084 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1143) CBP4 PF07960.6 CCF39976.1 - 3.4e-37 126.8 0.8 4.1e-37 126.6 0.6 1.0 1 0 0 1 1 1 1 CBP4 UPF0258 PF06789.7 CCF39976.1 - 0.045 13.7 0.2 0.061 13.3 0.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) FAP PF07174.6 CCF39977.1 - 0.47 9.6 6.0 0.53 9.5 4.1 1.0 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Fig1 PF12351.3 CCF39979.1 - 6.3e-56 189.1 2.8 6.3e-56 189.1 2.0 2.0 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.7 CCF39979.1 - 4e-10 39.6 5.5 6e-10 39.0 3.8 1.3 1 1 0 1 1 1 1 SUR7/PalI family DUF898 PF05987.8 CCF39979.1 - 1.7e-05 23.8 6.5 1.7e-05 23.8 4.5 1.8 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF898) DUF202 PF02656.10 CCF39979.1 - 0.068 13.3 9.0 0.22 11.7 0.0 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF202) MLTD_N PF06474.7 CCF39979.1 - 0.2 11.8 2.6 0.75 10.0 1.8 2.1 1 0 0 1 1 1 0 MltD lipid attachment motif DUF2976 PF11190.3 CCF39979.1 - 0.8 9.2 0.0 0.8 9.2 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2976) DUF3733 PF12534.3 CCF39979.1 - 1.8 7.9 4.2 8 5.8 0.1 2.7 2 0 0 2 2 2 0 Leucine-rich repeat containing protein 8 Glyco_hydro_47 PF01532.15 CCF39980.1 - 1.5e-95 320.5 0.0 1.8e-95 320.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 UCH PF00443.24 CCF39981.1 - 2e-22 79.5 0.1 3e-22 79.0 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CCF39981.1 - 5.7e-12 45.6 0.0 7e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PHD PF00628.24 CCF39981.1 - 0.11 12.1 2.6 0.66 9.7 0.4 2.4 2 0 0 2 2 2 0 PHD-finger RTA1 PF04479.8 CCF39982.1 - 3.5e-37 128.0 1.4 4.9e-37 127.6 1.0 1.1 1 0 0 1 1 1 1 RTA1 like protein DUF4117 PF13491.1 CCF39982.1 - 1.1 8.6 11.2 0.12 11.8 1.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4117) DUF2421 PF10334.4 CCF39984.1 - 0.00055 19.6 0.0 0.012 15.2 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2421) MOSC PF03473.12 CCF39989.1 - 1.8e-12 46.8 0.0 2.4e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 MOSC domain adh_short_C2 PF13561.1 CCF39990.1 - 9.9e-22 77.8 0.2 1.2e-21 77.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF39990.1 - 6.3e-18 65.2 0.1 8.1e-18 64.8 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Glyco_hydro_3 PF00933.16 CCF39991.1 - 9.2e-83 277.6 0.0 1.3e-82 277.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 CCF39991.1 - 2.5e-59 200.5 0.0 3.7e-59 199.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain PA14 PF07691.7 CCF39991.1 - 8.1e-13 48.2 0.1 1.8e-12 47.1 0.0 1.6 2 0 0 2 2 2 1 PA14 domain Fungal_trans PF04082.13 CCF39992.1 - 1.2e-08 34.1 0.4 1.3e-08 34.0 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sugar_tr PF00083.19 CCF39993.1 - 4.3e-88 295.8 27.8 5.2e-88 295.5 19.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF39993.1 - 6.8e-20 71.0 22.3 6.8e-20 71.0 15.5 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Actin PF00022.14 CCF39994.1 - 3.9e-133 443.6 0.0 4.4e-133 443.5 0.0 1.0 1 0 0 1 1 1 1 Actin Zn_clus PF00172.13 CCF39997.1 - 2.4e-05 24.1 8.0 3.8e-05 23.5 5.5 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PRCH PF03967.8 CCF39997.1 - 0.0049 16.4 0.0 0.023 14.3 0.0 2.1 2 0 0 2 2 2 1 Photosynthetic reaction centre, H-chain N-terminal region PSRT PF07636.6 CCF39997.1 - 0.041 13.3 0.5 0.095 12.1 0.3 1.6 1 0 0 1 1 1 0 PSRT NPP1 PF05630.6 CCF39998.1 - 5.5e-75 251.6 0.4 7e-75 251.2 0.3 1.1 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) Rhomboid PF01694.17 CCF39999.1 - 0.16 11.9 2.7 0.23 11.4 0.0 2.3 2 1 0 2 2 2 0 Rhomboid family Aldo_ket_red PF00248.16 CCF40000.1 - 9.1e-70 234.6 0.0 1e-69 234.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF1110 PF06533.7 CCF40002.1 - 0.015 15.1 1.0 0.031 14.0 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1110) DUF605 PF04652.11 CCF40002.1 - 0.22 10.8 9.4 0.29 10.5 6.5 1.2 1 0 0 1 1 1 0 Vta1 like Ustilago_mating PF05722.7 CCF40003.1 - 0.033 13.5 0.4 0.049 12.9 0.2 1.2 1 0 0 1 1 1 0 Ustilago B locus mating-type protein p450 PF00067.17 CCF40004.1 - 1.4e-29 102.9 0.0 4.1e-29 101.4 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 Glycos_transf_2 PF00535.21 CCF40007.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 DUF3095 PF11294.3 CCF40007.1 - 0.16 10.9 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3095) ERG4_ERG24 PF01222.12 CCF40008.1 - 1.1e-24 86.7 0.0 1.3e-24 86.5 0.0 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Peptidase_M28 PF04389.12 CCF40009.1 - 3.1e-36 124.7 0.0 6.4e-36 123.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 CCF40009.1 - 6.5e-14 51.4 0.4 8.2e-13 47.9 0.1 2.6 3 0 0 3 3 3 1 PA domain Peptidase_M20 PF01546.23 CCF40009.1 - 0.0016 17.9 0.0 0.0027 17.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Vps51 PF08700.6 CCF40010.1 - 3.3e-15 55.6 0.0 6.8e-15 54.6 0.0 1.5 1 0 0 1 1 1 1 Vps51/Vps67 DUF4525 PF15027.1 CCF40010.1 - 0.097 12.2 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) Sas10 PF09368.5 CCF40011.1 - 1.2e-29 102.3 8.2 1.2e-29 102.3 5.7 2.7 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.10 CCF40011.1 - 5.3e-12 45.7 0.0 5.3e-12 45.7 0.0 2.9 3 1 0 3 3 3 1 Sas10/Utp3/C1D family Med3 PF11593.3 CCF40011.1 - 0.0001 21.7 1.6 0.00018 20.8 1.1 1.4 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal adh_short PF00106.20 CCF40012.1 - 1e-21 77.5 1.0 1.6e-21 76.9 0.7 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF40012.1 - 1.7e-09 37.5 0.3 2.7e-09 36.9 0.2 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF40012.1 - 0.0001 22.1 0.0 0.00013 21.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Shikimate_DH PF01488.15 CCF40012.1 - 0.00035 20.6 0.2 0.00073 19.6 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.12 CCF40012.1 - 0.0012 19.1 0.1 0.032 14.6 0.3 2.4 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Eno-Rase_NADH_b PF12242.3 CCF40012.1 - 0.0032 17.2 0.0 0.0067 16.2 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_10 PF13460.1 CCF40012.1 - 0.0051 16.8 0.2 0.0092 15.9 0.1 1.5 1 0 0 1 1 1 1 NADH(P)-binding THF_DHG_CYH_C PF02882.14 CCF40012.1 - 0.019 14.0 0.0 0.033 13.2 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ApbA PF02558.11 CCF40012.1 - 0.031 13.7 0.0 0.059 12.8 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.13 CCF40012.1 - 0.049 13.2 0.4 0.081 12.5 0.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.10 CCF40012.1 - 0.11 12.3 0.1 0.18 11.6 0.1 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Urb2 PF10441.4 CCF40013.1 - 4.4e-57 193.2 0.5 1.6e-56 191.4 0.4 2.1 1 0 0 1 1 1 1 Urb2/Npa2 family DUF543 PF04418.7 CCF40014.1 - 3.4e-29 100.6 0.0 3.7e-29 100.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) DUF834 PF05754.9 CCF40016.1 - 0.072 12.9 0.1 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF834) Fungal_trans PF04082.13 CCF40017.1 - 1.1e-09 37.5 0.0 1.6e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF40017.1 - 1.7e-06 27.8 10.2 4.4e-06 26.4 7.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Amino_oxidase PF01593.19 CCF40020.1 - 1.4e-24 87.0 2.0 6e-18 65.1 0.0 2.7 3 1 0 4 4 4 2 Flavin containing amine oxidoreductase Mre11_DNA_bind PF04152.9 CCF40021.1 - 1.8e-38 132.1 0.2 2.5e-38 131.6 0.1 1.2 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.23 CCF40021.1 - 5.7e-24 84.6 2.7 7.3e-24 84.2 1.9 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CCF40021.1 - 1.3e-06 28.3 0.1 2.9e-06 27.2 0.1 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain LRV PF01816.12 CCF40022.1 - 0.065 13.4 0.6 0.22 11.8 0.1 2.1 2 0 0 2 2 2 0 Leucine rich repeat variant SulA PF03846.9 CCF40022.1 - 0.093 12.4 0.2 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 Cell division inhibitor SulA EF-hand_4 PF12763.2 CCF40024.1 - 5.8e-25 87.0 0.0 4.8e-13 48.7 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand DUF1720 PF08226.6 CCF40024.1 - 1.7e-05 24.7 83.0 6.6e-05 22.8 22.2 7.3 5 2 2 7 7 7 3 Domain of unknown function (DUF1720) EF-hand_7 PF13499.1 CCF40024.1 - 0.0029 17.7 0.0 0.58 10.3 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 CCF40024.1 - 0.0078 15.4 0.0 1.3 8.5 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 CCF40024.1 - 0.016 15.0 0.1 3.4 7.7 0.0 3.4 3 0 0 3 3 3 0 EF-hand domain Herpes_UL87 PF03043.9 CCF40024.1 - 1.2 7.4 2.8 1.9 6.7 1.9 1.3 1 0 0 1 1 1 0 Herpesvirus UL87 family p450 PF00067.17 CCF40025.1 - 1.3e-17 63.5 0.0 1.5e-17 63.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Amidase PF01425.16 CCF40027.1 - 7.4e-32 110.7 3.6 7.4e-32 110.7 2.5 1.4 2 0 0 2 2 2 1 Amidase zf-UBR PF02207.15 CCF40028.1 - 1.8e-18 66.0 9.4 3.3e-18 65.1 6.5 1.4 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.12 CCF40028.1 - 2.6e-09 36.6 0.0 7e-09 35.2 0.0 1.7 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS DUF2067 PF09840.4 CCF40028.1 - 0.061 12.8 0.7 0.15 11.5 0.0 2.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2067) FBPase PF00316.15 CCF40028.1 - 0.08 11.7 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 Fructose-1-6-bisphosphatase PS-DH PF14765.1 CCF40029.1 - 1.1e-26 93.6 0.0 1.3e-26 93.4 0.0 1.0 1 0 0 1 1 1 1 Polyketide synthase dehydratase FAD_binding_4 PF01565.18 CCF40030.1 - 9.4e-30 102.9 0.6 2.7e-29 101.3 0.3 1.7 2 0 0 2 2 2 1 FAD binding domain Hydant_A_N PF05378.8 CCF40031.1 - 4.1e-48 163.2 0.0 5.5e-48 162.7 0.0 1.1 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.13 CCF40031.1 - 0.13 11.2 0.0 0.41 9.7 0.0 1.8 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase RNase_H PF00075.19 CCF40032.1 - 1e-17 64.7 0.4 2e-17 63.7 0.2 1.4 1 0 0 1 1 1 1 RNase H COG2 PF06148.6 CCF40033.1 - 1.5e-24 86.4 0.0 2.2e-24 85.7 0.0 1.2 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.6 CCF40033.1 - 0.0013 18.5 0.0 0.0052 16.5 0.0 2.0 1 1 0 2 2 2 1 Vps51/Vps67 CENP-B_dimeris PF09026.5 CCF40033.1 - 0.035 14.3 1.7 0.1 12.8 1.2 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CENP-F_leu_zip PF10473.4 CCF40033.1 - 0.042 13.7 0.4 0.085 12.7 0.2 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Ribosomal_L1 PF00687.16 CCF40034.1 - 1.2e-08 34.5 0.0 1.4e-08 34.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family cobW PF02492.14 CCF40035.1 - 8.9e-21 74.1 0.4 1.1e-20 73.8 0.3 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain Arch_ATPase PF01637.13 CCF40035.1 - 0.0019 17.9 0.0 0.0022 17.7 0.0 1.1 1 0 0 1 1 1 1 Archaeal ATPase AAA_23 PF13476.1 CCF40035.1 - 0.0033 17.7 0.1 0.0039 17.5 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CCF40035.1 - 0.004 16.8 0.1 0.0053 16.4 0.1 1.3 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 CCF40035.1 - 0.0051 16.8 0.0 0.006 16.5 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.1 CCF40035.1 - 0.008 16.4 0.1 0.012 15.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 CCF40035.1 - 0.013 14.9 0.0 0.016 14.6 0.0 1.1 1 0 0 1 1 1 0 AAA-like domain AAA_22 PF13401.1 CCF40035.1 - 0.018 15.1 0.0 0.022 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 CCF40035.1 - 0.022 14.2 0.0 0.03 13.8 0.0 1.2 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 CCF40035.1 - 0.024 14.5 0.0 0.028 14.3 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase MobB PF03205.9 CCF40035.1 - 0.025 14.2 0.1 0.03 14.0 0.0 1.2 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ArgK PF03308.11 CCF40035.1 - 0.029 13.1 0.1 0.04 12.6 0.1 1.2 1 0 0 1 1 1 0 ArgK protein AAA_14 PF13173.1 CCF40035.1 - 0.039 13.8 0.0 0.045 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 CCF40035.1 - 0.041 12.7 0.2 0.046 12.6 0.1 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF258 PF03193.11 CCF40035.1 - 0.061 12.4 0.0 0.061 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ABC_tran PF00005.22 CCF40035.1 - 0.073 13.3 0.3 0.11 12.8 0.2 1.3 1 1 0 1 1 1 0 ABC transporter Zeta_toxin PF06414.7 CCF40035.1 - 0.085 11.9 0.0 0.095 11.7 0.0 1.1 1 0 0 1 1 1 0 Zeta toxin UPF0079 PF02367.12 CCF40035.1 - 0.092 12.3 0.2 0.14 11.8 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Miro PF08477.8 CCF40035.1 - 0.12 12.8 0.0 0.17 12.3 0.0 1.2 1 0 0 1 1 1 0 Miro-like protein NTPase_1 PF03266.10 CCF40035.1 - 0.14 11.8 0.2 0.2 11.3 0.1 1.2 1 0 0 1 1 1 0 NTPase Mob1_phocein PF03637.12 CCF40036.1 - 1.9e-25 89.5 0.2 3e-25 88.8 0.2 1.2 1 0 0 1 1 1 1 Mob1/phocein family Fungal_trans_2 PF11951.3 CCF40037.1 - 5.1e-11 41.8 3.2 1.8e-10 39.9 2.2 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF40037.1 - 4.3e-07 29.7 9.1 7.7e-07 28.9 6.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.13 CCF40038.1 - 8.6e-11 41.5 12.5 1.3e-10 40.9 8.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF40038.1 - 0.0069 15.2 0.0 0.013 14.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain SecY PF00344.15 CCF40039.1 - 1.1e-95 320.5 9.4 1.4e-95 320.2 6.5 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 CCF40039.1 - 1.4e-17 62.8 0.1 1.1e-16 60.0 0.2 2.4 2 0 0 2 2 2 1 Plug domain of Sec61p IPPT PF01715.12 CCF40040.1 - 1.2e-22 80.1 0.0 1.5e-22 79.8 0.0 1.1 1 0 0 1 1 1 1 IPP transferase AAA_17 PF13207.1 CCF40040.1 - 1.5e-06 29.0 0.0 1.9e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain IPT PF01745.11 CCF40040.1 - 8.3e-06 25.1 0.0 8.9e-06 25.0 0.0 1.1 1 0 0 1 1 1 1 Isopentenyl transferase AAA_18 PF13238.1 CCF40040.1 - 0.0016 18.7 0.1 0.0018 18.6 0.1 1.3 1 1 0 1 1 1 1 AAA domain Hpr_kinase_C PF07475.7 CCF40040.1 - 0.0024 17.2 0.0 0.0032 16.8 0.0 1.2 1 0 0 1 1 1 1 HPr Serine kinase C-terminal domain AAA_33 PF13671.1 CCF40040.1 - 0.0027 17.5 0.0 0.0031 17.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 CCF40040.1 - 0.0035 17.4 0.0 0.0072 16.4 0.0 1.6 1 1 0 1 1 1 1 RNA helicase AAA_28 PF13521.1 CCF40040.1 - 0.0064 16.4 0.0 0.0075 16.2 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CCF40040.1 - 0.0067 16.1 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 CCF40040.1 - 0.011 15.4 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 CCF40040.1 - 0.011 14.8 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.1 CCF40040.1 - 0.011 15.8 0.0 0.027 14.6 0.0 1.5 1 1 1 2 2 2 0 AAA domain AAA_25 PF13481.1 CCF40040.1 - 0.022 14.1 0.0 0.034 13.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain PhoH PF02562.11 CCF40040.1 - 0.025 13.7 0.0 0.032 13.4 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.22 CCF40040.1 - 0.032 14.5 0.0 0.036 14.3 0.0 1.2 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.1 CCF40040.1 - 0.036 14.0 0.0 0.045 13.7 0.0 1.2 1 1 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.12 CCF40040.1 - 0.048 13.0 0.0 0.056 12.8 0.0 1.2 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA PF00004.24 CCF40040.1 - 0.065 13.4 0.0 0.065 13.4 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) KTI12 PF08433.5 CCF40040.1 - 0.073 12.2 0.0 0.085 12.0 0.0 1.1 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DUF87 PF01935.12 CCF40040.1 - 0.082 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF87 Sugar_tr PF00083.19 CCF40041.1 - 5.3e-26 91.2 13.4 6.2e-26 90.9 9.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF40041.1 - 1.7e-10 40.1 10.7 2.4e-10 39.7 7.4 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF40041.1 - 0.00059 18.3 3.8 0.00082 17.8 2.7 1.2 1 0 0 1 1 1 1 MFS/sugar transport protein TRI12 PF06609.8 CCF40041.1 - 0.0012 17.0 2.4 0.0014 16.9 1.7 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF791 PF05631.9 CCF40041.1 - 0.0014 17.4 1.7 0.0019 16.9 1.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF791) HupE_UreJ_2 PF13795.1 CCF40041.1 - 0.0045 16.4 1.2 0.0067 15.9 0.8 1.3 1 0 0 1 1 1 1 HupE / UreJ protein DUF3792 PF12670.2 CCF40041.1 - 0.13 12.1 12.6 0.065 13.1 5.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) MFS_3 PF05977.8 CCF40041.1 - 0.23 9.5 5.6 0.89 7.5 3.9 1.7 1 1 0 1 1 1 0 Transmembrane secretion effector NKAIN PF05640.9 CCF40041.1 - 3.9 6.3 6.1 2.5 6.9 2.1 1.9 1 1 1 2 2 2 0 Na,K-Atpase Interacting protein Acetyltransf_10 PF13673.1 CCF40042.1 - 2.9e-05 24.1 0.0 5.7e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF40042.1 - 3.9e-05 23.3 0.0 7.1e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_1 PF00583.19 CCF40042.1 - 0.00071 19.5 0.0 0.0015 18.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.1 CCF40042.1 - 0.044 13.9 0.0 0.072 13.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DAO PF01266.19 CCF40044.1 - 8.1e-35 120.3 0.0 1.2e-34 119.8 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF40044.1 - 9.3e-07 28.9 0.0 0.0066 16.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF40044.1 - 1.1e-06 28.5 0.1 0.0048 16.6 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Trp_halogenase PF04820.9 CCF40044.1 - 1.3e-06 27.3 0.3 0.0032 16.1 0.1 2.2 2 0 0 2 2 2 2 Tryptophan halogenase Pyr_redox_3 PF13738.1 CCF40044.1 - 0.0014 18.7 0.1 0.21 11.6 0.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF40044.1 - 0.0021 18.0 0.0 0.0074 16.2 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.15 CCF40044.1 - 0.0039 17.2 0.0 0.007 16.4 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GIDA PF01134.17 CCF40044.1 - 0.0051 15.7 0.0 0.15 10.8 0.0 2.3 2 1 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_3 PF01494.14 CCF40044.1 - 0.0082 15.2 0.0 0.015 14.3 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain ApbA PF02558.11 CCF40044.1 - 0.032 13.6 0.0 0.11 11.8 0.0 1.9 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.13 CCF40044.1 - 0.053 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Thi4 PF01946.12 CCF40044.1 - 0.077 12.0 0.0 0.18 10.8 0.0 1.6 2 0 0 2 2 2 0 Thi4 family GMC_oxred_N PF00732.14 CCF40044.1 - 0.079 12.1 0.1 4.5 6.3 0.0 2.3 2 0 0 2 2 2 0 GMC oxidoreductase NAD_binding_7 PF13241.1 CCF40044.1 - 0.11 12.7 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.13 CCF40044.1 - 0.12 12.0 0.0 0.39 10.3 0.0 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.16 CCF40044.1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 ThiF family MFS_1 PF07690.11 CCF40045.1 - 1.4e-06 27.3 8.6 1.4e-06 27.3 6.0 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily HlyIII PF03006.15 CCF40045.1 - 1.5 8.1 10.0 2.5 7.4 2.0 2.3 1 1 0 2 2 2 0 Haemolysin-III related CAP_GLY PF01302.20 CCF40047.1 - 5.9e-24 83.5 0.5 9e-24 82.9 0.3 1.3 1 0 0 1 1 1 1 CAP-Gly domain Pyr_redox_2 PF07992.9 CCF40049.1 - 2.7e-16 60.0 0.0 3.7e-16 59.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF40049.1 - 4.7e-07 30.0 0.2 0.016 15.2 0.0 2.5 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF40049.1 - 2e-05 24.4 0.7 0.14 11.9 0.0 2.6 2 0 0 2 2 2 2 FAD-NAD(P)-binding K_oxygenase PF13434.1 CCF40049.1 - 6.5e-05 22.0 0.1 0.053 12.4 0.0 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.9 CCF40049.1 - 0.00015 20.4 0.3 0.0024 16.3 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.7 CCF40049.1 - 0.00035 19.5 0.1 0.0056 15.6 0.0 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_2 PF00890.19 CCF40049.1 - 0.00051 19.0 0.1 0.0055 15.5 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.17 CCF40049.1 - 0.00051 19.0 1.2 0.17 10.6 0.0 2.2 1 1 1 2 2 2 2 Glucose inhibited division protein A DAO PF01266.19 CCF40049.1 - 0.0008 18.4 2.2 0.0047 15.8 0.1 2.2 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF40049.1 - 0.006 16.5 0.0 0.015 15.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 CCF40049.1 - 0.033 13.2 0.1 0.055 12.5 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.12 CCF40049.1 - 0.064 12.3 0.1 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.22 CCF40049.1 - 0.13 12.6 0.4 0.4 11.1 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lipase_GDSL_2 PF13472.1 CCF40051.1 - 2.6e-19 70.0 3.4 7.5e-19 68.5 2.3 1.8 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 CCF40051.1 - 2.3e-15 57.0 0.1 6.8e-15 55.5 0.1 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase VWA_3 PF13768.1 CCF40051.1 - 0.11 12.1 0.0 0.31 10.7 0.0 1.7 1 0 0 1 1 1 0 von Willebrand factor type A domain GATA PF00320.22 CCF40053.1 - 1.6e-16 59.3 1.9 3.3e-16 58.3 1.3 1.6 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.5 CCF40053.1 - 2.2e-13 49.5 0.8 4e-13 48.6 0.5 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) p450 PF00067.17 CCF40055.1 - 1.4e-10 40.3 0.6 3e-09 35.9 0.4 2.3 1 1 0 1 1 1 1 Cytochrome P450 TauD PF02668.11 CCF40056.1 - 4.5e-28 98.6 0.6 5.9e-28 98.2 0.4 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.5 CCF40056.1 - 0.027 13.3 0.0 0.046 12.6 0.0 1.3 1 0 0 1 1 1 0 CsiD AA_permease_2 PF13520.1 CCF40057.1 - 3.3e-71 240.0 38.9 4.1e-71 239.7 27.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF40057.1 - 2.7e-17 62.2 36.8 6.4e-17 61.0 25.5 1.5 1 1 0 1 1 1 1 Amino acid permease YCII PF03795.9 CCF40058.1 - 0.039 14.1 0.0 0.046 13.9 0.0 1.1 1 0 0 1 1 1 0 YCII-related domain Tir_receptor_C PF07489.6 CCF40059.1 - 9.2 5.9 12.8 15 5.2 8.8 1.3 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Pectate_lyase PF03211.8 CCF40060.1 - 3.2e-53 180.3 0.0 3.9e-53 180.0 0.0 1.0 1 0 0 1 1 1 1 Pectate lyase DUF3328 PF11807.3 CCF40062.1 - 1.1e-47 162.4 1.1 1.4e-47 162.1 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Y_phosphatase PF00102.22 CCF40064.1 - 3.9e-13 49.2 0.0 4.9e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase MARVEL PF01284.18 CCF40065.1 - 1.1e-18 67.3 13.5 1.4e-18 67.1 9.3 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF4328 PF14219.1 CCF40065.1 - 0.01 15.1 0.5 0.01 15.1 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4328) ABC2_membrane_5 PF13346.1 CCF40065.1 - 0.16 11.2 6.5 0.23 10.7 4.5 1.3 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF308 PF03729.8 CCF40065.1 - 1.2 9.1 15.2 0.59 10.1 2.5 3.2 3 0 0 3 3 3 0 Short repeat of unknown function (DUF308) DUF924 PF06041.6 CCF40066.1 - 2.4e-29 102.4 0.1 3e-29 102.0 0.1 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) Glyco_hydro_11 PF00457.12 CCF40067.1 - 8.4e-59 197.9 15.5 1e-58 197.6 10.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 MFS_1 PF07690.11 CCF40068.1 - 3.4e-40 137.8 56.6 9.2e-34 116.6 30.1 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF40068.1 - 2.8e-13 48.9 27.9 4e-13 48.4 19.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 CCF40068.1 - 3.8e-05 22.4 14.7 3.8e-05 22.4 10.2 3.8 1 1 2 3 3 3 1 Sugar (and other) transporter FeS PF04060.8 CCF40071.1 - 0.16 11.5 9.2 0.2 11.2 3.0 2.1 2 0 0 2 2 2 0 Putative Fe-S cluster Rubredoxin PF00301.15 CCF40071.1 - 0.17 11.8 0.2 0.17 11.8 0.1 2.0 2 0 0 2 2 2 0 Rubredoxin zf-ribbon_3 PF13248.1 CCF40071.1 - 3.1 7.1 8.7 7.3 5.9 5.7 1.9 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 CCF40071.1 - 8.8 5.9 10.4 74 3.0 6.7 2.3 1 1 0 1 1 1 0 zinc-ribbon domain Ebp2 PF05890.7 CCF40072.1 - 2.3e-85 286.1 14.6 2.3e-85 286.1 10.1 3.0 1 1 0 2 2 2 1 Eukaryotic rRNA processing protein EBP2 Daxx PF03344.10 CCF40072.1 - 3.4 6.0 41.2 0.028 12.9 19.2 2.1 2 0 0 2 2 2 0 Daxx Family Fic PF02661.13 CCF40073.1 - 1.8e-19 70.2 0.0 3.8e-19 69.1 0.0 1.6 1 0 0 1 1 1 1 Fic/DOC family McrBC PF10117.4 CCF40073.1 - 0.041 12.8 0.0 0.051 12.5 0.0 1.2 1 0 0 1 1 1 0 McrBC 5-methylcytosine restriction system component CP2 PF04516.10 CCF40075.1 - 6.4e-85 283.9 0.0 9.8e-85 283.3 0.0 1.2 1 0 0 1 1 1 1 CP2 transcription factor Tektin PF03148.9 CCF40075.1 - 0.016 13.7 0.0 0.025 13.1 0.0 1.2 1 0 0 1 1 1 0 Tektin family Phage_G PF02306.10 CCF40075.1 - 0.071 12.7 0.1 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Major spike protein (G protein) Not3 PF04065.10 CCF40075.1 - 0.12 11.6 0.6 0.2 10.8 0.4 1.3 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component TMF_DNA_bd PF12329.3 CCF40075.1 - 0.13 12.0 0.7 0.26 11.0 0.5 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Glyco_tranf_2_3 PF13641.1 CCF40077.1 - 3.1e-14 53.3 1.1 4.4e-14 52.8 0.8 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 CCF40077.1 - 0.0018 18.0 0.0 0.003 17.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 SSF PF00474.12 CCF40078.1 - 8.4e-17 60.8 34.9 1.3e-16 60.2 23.1 1.9 2 0 0 2 2 2 1 Sodium:solute symporter family p450 PF00067.17 CCF40080.1 - 1.8e-37 129.0 0.0 3e-36 124.9 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 HpaB PF03241.8 CCF40080.1 - 0.04 12.7 0.0 0.15 10.8 0.0 1.8 2 0 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase C terminal Orthopox_A36R PF05950.6 CCF40082.1 - 0.33 10.8 7.1 0.54 10.1 4.9 1.3 1 0 0 1 1 1 0 Orthopoxvirus A36R protein RR_TM4-6 PF06459.7 CCF40082.1 - 0.33 10.8 4.6 0.3 10.9 3.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FLO_LFY PF01698.11 CCF40082.1 - 0.66 8.7 4.9 0.71 8.6 3.4 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein Neur_chan_memb PF02932.11 CCF40082.1 - 1 9.2 3.3 1 9.1 2.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Herpes_pp38 PF04846.8 CCF40085.1 - 0.056 12.7 0.1 0.12 11.7 0.1 1.5 1 0 0 1 1 1 0 Herpesvirus pp38 phosphoprotein TMEM51 PF15345.1 CCF40086.1 - 0.096 12.3 0.5 0.18 11.4 0.3 1.5 1 1 0 1 1 1 0 Transmembrane protein 51 WBP-1 PF11669.3 CCF40086.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 WW domain-binding protein 1 RskA PF10099.4 CCF40088.1 - 0.0044 16.7 0.3 0.0048 16.6 0.2 1.0 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Baculo_11_kDa PF06143.6 CCF40089.1 - 1.7 8.0 4.9 2.2 7.7 1.2 2.7 2 0 0 2 2 2 0 Baculovirus 11 kDa family Ribosomal_L13e PF01294.13 CCF40091.1 - 3.8e-64 215.4 1.7 4.9e-64 215.0 1.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L13e PS-DH PF14765.1 CCF40093.1 - 2.1e-44 151.8 0.0 4.5e-44 150.7 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.16 CCF40093.1 - 7.9e-15 54.9 0.0 2e-14 53.6 0.0 1.7 2 0 0 2 2 2 1 Acyl transferase domain 2OG-FeII_Oxy PF03171.15 CCF40094.1 - 0.00037 20.7 0.0 0.00076 19.7 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 CCF40094.1 - 0.024 15.1 0.1 0.051 14.0 0.1 1.6 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DUF621 PF04789.10 CCF40094.1 - 0.04 12.9 0.1 0.055 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF621) 2OG-FeII_Oxy_4 PF13661.1 CCF40094.1 - 0.097 12.3 0.1 0.21 11.2 0.1 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DDE_1 PF03184.14 CCF40095.1 - 8.9e-16 57.6 0.0 1.5e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.11 CCF40095.1 - 9.5e-13 47.4 0.0 1.7e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF40095.1 - 1.6e-09 37.4 0.1 4.7e-09 35.9 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.1 CCF40095.1 - 0.00082 18.9 0.2 0.0051 16.4 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 CCF40095.1 - 0.072 13.1 0.1 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Phage_CP76 PF06892.6 CCF40095.1 - 0.13 11.5 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Phage regulatory protein CII (CP76) DPM2 PF07297.7 CCF40096.1 - 8.3e-20 70.8 0.1 1e-19 70.6 0.0 1.1 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF4229 PF14012.1 CCF40096.1 - 0.00094 19.0 0.3 0.001 18.9 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4229) DUF4083 PF13314.1 CCF40096.1 - 0.0055 16.4 0.1 0.0067 16.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4083) DUF1049 PF06305.6 CCF40096.1 - 0.048 13.1 0.2 0.063 12.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) PIG-P PF08510.7 CCF40096.1 - 0.13 11.9 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 PIG-P Asparaginase_2 PF01112.13 CCF40098.1 - 6e-35 120.4 1.6 2e-19 69.4 0.0 2.2 2 0 0 2 2 2 2 Asparaginase Tfb4 PF03850.9 CCF40099.1 - 9.3e-48 162.8 1.5 1.1e-47 162.6 1.1 1.1 1 0 0 1 1 1 1 Transcription factor Tfb4 zf-C2HC5 PF06221.8 CCF40099.1 - 0.0069 16.1 4.6 0.011 15.4 3.2 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type Pex14_N PF04695.8 CCF40100.1 - 4.7 7.2 6.2 20 5.2 3.0 2.4 2 1 1 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF59 PF01883.14 CCF40104.1 - 2.3e-05 24.3 0.0 7.4e-05 22.6 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function DUF59 Thioredoxin PF00085.15 CCF40105.1 - 2.2e-25 88.3 0.0 2.9e-25 87.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 CCF40105.1 - 9.5e-08 32.0 0.0 2.3e-06 27.6 0.0 1.9 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_7 PF13899.1 CCF40105.1 - 7.6e-07 29.0 0.1 1.2e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 CCF40105.1 - 1.1e-06 28.7 0.2 1.1e-05 25.5 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.16 CCF40105.1 - 1.2e-05 25.0 0.0 2.2e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 CCF40105.1 - 1.3e-05 24.7 0.0 1.7e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Redoxin HyaE PF07449.6 CCF40105.1 - 1.5e-05 24.8 0.0 2.2e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.1 CCF40105.1 - 0.0019 17.7 0.0 0.0024 17.4 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.1 CCF40105.1 - 0.038 13.4 0.0 0.066 12.6 0.0 1.3 1 1 0 1 1 1 0 F plasmid transfer operon protein TrbC_Ftype PF09673.5 CCF40105.1 - 0.12 11.9 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein Adeno_E3B PF03376.9 CCF40107.1 - 0.054 13.3 1.6 0.077 12.9 0.2 1.9 2 0 0 2 2 2 0 Adenovirus E3B protein Reticulon PF02453.12 CCF40107.1 - 0.98 9.0 8.2 0.78 9.3 2.3 2.0 1 1 1 2 2 2 0 Reticulon Pkinase PF00069.20 CCF40108.1 - 3.1e-78 262.5 0.0 3.6e-78 262.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF40108.1 - 2.4e-38 131.6 0.0 3.2e-38 131.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF40108.1 - 0.0012 17.8 0.0 0.0031 16.5 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 CCF40108.1 - 0.0084 15.1 0.1 0.014 14.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CCF40108.1 - 0.018 14.7 0.0 0.084 12.5 0.0 1.9 1 1 0 2 2 2 0 Phosphotransferase enzyme family Acyltransferase PF01553.16 CCF40109.1 - 0.00044 19.6 0.0 0.00073 18.9 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Glycoprotein_B PF00606.13 CCF40110.1 - 0.055 11.4 1.8 0.056 11.4 1.3 1.0 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B MDFI PF15316.1 CCF40110.1 - 0.13 12.2 2.5 0.1 12.6 1.0 1.3 1 1 0 1 1 1 0 MyoD family inhibitor ERCC4 PF02732.10 CCF40111.1 - 2.4e-25 88.9 0.0 8.6e-25 87.1 0.0 2.0 1 0 0 1 1 1 1 ERCC4 domain HHH_5 PF14520.1 CCF40111.1 - 0.08 13.1 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain Abhydro_lipase PF04083.11 CCF40112.1 - 9.2e-20 69.7 0.0 1.8e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_6 PF12697.2 CCF40112.1 - 1.1e-07 32.0 0.1 1.7e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF40112.1 - 6.5e-05 22.7 0.0 0.00014 21.6 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family MFS_1 PF07690.11 CCF40113.1 - 1.4e-25 89.8 20.7 2.2e-25 89.1 14.4 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2892 PF11127.3 CCF40113.1 - 2 8.3 5.5 1.7 8.5 1.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2892) BNR PF02012.15 CCF40114.1 - 0.033 13.9 31.6 0.75 9.8 0.7 6.5 6 0 0 6 6 6 0 BNR/Asp-box repeat Cyclin PF08613.6 CCF40115.1 - 7.3e-14 52.4 0.0 1.2e-13 51.6 0.0 1.4 1 0 0 1 1 1 1 Cyclin Galactosyl_T PF01762.16 CCF40116.1 - 2.3e-13 50.1 0.6 1.8e-12 47.2 0.4 2.0 1 1 0 1 1 1 1 Galactosyltransferase DUF4131 PF13567.1 CCF40116.1 - 0.0069 15.8 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) Malic_M PF03949.10 CCF40117.1 - 2.8e-80 269.5 0.0 3.9e-80 269.0 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 CCF40117.1 - 9.4e-65 217.5 0.0 1.4e-64 217.0 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain COesterase PF00135.23 CCF40118.1 - 1.4e-97 327.6 0.0 1.9e-97 327.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF40118.1 - 3.7e-08 33.1 0.1 1.2e-07 31.5 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF40118.1 - 0.00021 21.0 0.1 0.00044 20.0 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family MFS_1 PF07690.11 CCF40119.1 - 1.5e-33 115.9 33.5 1.8e-33 115.7 23.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1228 PF06779.9 CCF40119.1 - 1.4 8.9 7.9 0.21 11.6 0.5 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1228) Ribosomal_S21e PF01249.13 CCF40120.1 - 1e-40 137.5 0.0 1.1e-40 137.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Slx4 PF09494.5 CCF40121.1 - 5.5e-23 80.4 0.0 1.2e-22 79.4 0.0 1.6 1 0 0 1 1 1 1 Slx4 endonuclease His_biosynth PF00977.16 CCF40125.1 - 2.5e-32 112.0 0.0 1.2e-31 109.8 0.0 1.8 1 1 0 1 1 1 1 Histidine biosynthesis protein Dus PF01207.12 CCF40125.1 - 0.0035 16.2 0.0 0.0052 15.6 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) SAP PF02037.22 CCF40125.1 - 0.081 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 SAP domain ODC_AZ PF02100.12 CCF40126.1 - 1.4e-24 85.7 0.0 2.4e-24 84.9 0.0 1.4 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme TPR_11 PF13414.1 CCF40127.1 - 2.6e-19 68.6 6.1 1e-15 57.0 0.1 2.5 1 1 1 2 2 2 2 TPR repeat U-box PF04564.10 CCF40127.1 - 2.7e-18 65.6 0.0 5.2e-18 64.7 0.0 1.5 1 0 0 1 1 1 1 U-box domain TPR_2 PF07719.12 CCF40127.1 - 9.5e-10 37.6 4.9 0.00013 21.6 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 CCF40127.1 - 5.1e-09 36.5 4.1 2.2e-05 24.9 0.1 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 CCF40127.1 - 6.3e-08 32.8 1.8 0.0025 18.1 0.2 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 CCF40127.1 - 2e-07 30.2 4.1 0.0068 15.9 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 CCF40127.1 - 4.1e-06 26.9 2.8 0.00053 20.3 0.1 3.1 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 CCF40127.1 - 4.9e-06 26.3 4.1 0.05 13.8 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 CCF40127.1 - 7.5e-05 22.5 6.9 0.024 14.5 2.0 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 CCF40127.1 - 0.00016 21.4 0.2 0.0005 19.8 0.1 1.9 1 1 0 1 1 1 1 Tetratricopeptide repeat Apc3 PF12895.2 CCF40127.1 - 0.0018 18.3 1.0 0.0073 16.4 0.6 2.1 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.1 CCF40127.1 - 0.0077 16.1 5.8 0.22 11.5 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 CCF40127.1 - 0.037 13.7 2.4 2.6 8.0 0.7 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 CCF40127.1 - 0.07 12.9 1.8 2.8 7.9 0.0 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.9 CCF40127.1 - 0.13 12.7 0.4 5.7 7.6 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Spore_coat_CotO PF14153.1 CCF40127.1 - 0.19 11.1 4.6 0.27 10.6 3.2 1.2 1 0 0 1 1 1 0 Spore coat protein CotO TPR_6 PF13174.1 CCF40127.1 - 0.28 11.7 3.1 33 5.2 0.0 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CCF40127.1 - 1.5 8.7 5.1 2.1 8.3 0.2 3.4 4 1 1 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat Spatacsin_C PF14649.1 CCF40128.1 - 0.15 10.9 4.4 0.29 9.9 3.1 1.5 1 1 0 1 1 1 0 Spatacsin C-terminus DUF3835 PF12927.2 CCF40128.1 - 0.76 10.7 9.5 3.1 8.8 0.7 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3835) DUF2559 PF10832.3 CCF40128.1 - 2.2 8.1 8.9 0.35 10.6 0.3 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF2559) Glyco_hydro_10 PF00331.15 CCF40129.1 - 2.8e-80 269.7 0.0 3.3e-80 269.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Glyco_hydro_42 PF02449.10 CCF40129.1 - 0.054 12.6 0.1 0.11 11.5 0.0 1.4 2 0 0 2 2 2 0 Beta-galactosidase DUF4339 PF14237.1 CCF40129.1 - 0.075 12.6 0.1 0.23 11.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4339) HTH_42 PF06224.7 CCF40129.1 - 0.079 12.2 0.1 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain CENP-L PF13092.1 CCF40130.1 - 1.6e-52 177.5 0.0 1.2e-51 174.7 0.0 2.1 2 0 0 2 2 2 1 Kinetochore complex Sim4 subunit Fta1 WD40 PF00400.27 CCF40132.1 - 4.7e-53 175.2 23.8 5.4e-09 35.6 0.4 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_90kDa PF04494.10 CCF40132.1 - 4.8e-43 146.6 0.7 6.7e-43 146.1 0.5 1.2 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit Nucleoporin_N PF08801.6 CCF40132.1 - 6.6e-07 28.4 0.5 0.023 13.4 0.0 3.8 2 2 1 3 3 3 2 Nup133 N terminal like eIF2A PF08662.6 CCF40132.1 - 3.9e-06 26.7 0.2 0.0028 17.4 0.0 3.4 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A LisH PF08513.6 CCF40132.1 - 5.3e-06 25.9 0.0 1.1e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 LisH Nup160 PF11715.3 CCF40132.1 - 0.0096 14.1 3.1 3.7 5.5 0.0 3.2 1 1 1 3 3 3 3 Nucleoporin Nup120/160 AsnC_trans_reg PF01037.16 CCF40132.1 - 0.14 11.8 0.1 0.81 9.4 0.0 2.2 2 0 0 2 2 2 0 AsnC family DEC-1_N PF04625.8 CCF40132.1 - 0.88 8.1 9.3 1.5 7.4 6.4 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Ribul_P_3_epim PF00834.14 CCF40133.1 - 2.6e-33 114.8 0.1 1.1e-32 112.7 0.0 1.8 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.14 CCF40133.1 - 0.005 16.3 0.0 0.0081 15.6 0.0 1.4 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain OMPdecase PF00215.19 CCF40133.1 - 0.011 15.1 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family ThiG PF05690.9 CCF40133.1 - 0.013 14.5 0.2 0.016 14.2 0.1 1.1 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG Aminotran_5 PF00266.14 CCF40134.1 - 1.7e-54 185.0 0.0 3.1e-54 184.1 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 CCF40134.1 - 0.00014 20.3 0.0 0.0002 19.7 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 CCF40134.1 - 0.0072 15.3 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Flavodoxin_5 PF12724.2 CCF40134.1 - 0.15 12.0 0.0 0.35 10.8 0.0 1.7 1 0 0 1 1 1 0 Flavodoxin domain 2OG-FeII_Oxy_3 PF13640.1 CCF40135.1 - 0.00023 21.6 0.0 0.0004 20.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ofd1_CTDD PF10637.4 CCF40135.1 - 0.021 13.9 0.0 0.037 13.1 0.0 1.3 1 1 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term SNO PF01174.14 CCF40137.1 - 5e-47 159.9 0.0 1.7e-45 154.9 0.0 2.0 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.9 CCF40137.1 - 2e-07 30.7 0.0 1.5e-06 27.8 0.0 2.0 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.23 CCF40137.1 - 6.2e-05 22.5 0.0 0.05 13.0 0.0 2.1 2 0 0 2 2 2 2 Glutamine amidotransferase class-I DJ-1_PfpI PF01965.19 CCF40137.1 - 0.00054 19.4 0.0 0.00075 18.9 0.0 1.4 1 1 0 1 1 1 1 DJ-1/PfpI family DUF4066 PF13278.1 CCF40137.1 - 0.0011 18.2 0.0 0.0021 17.3 0.0 1.4 1 0 0 1 1 1 1 Putative amidotransferase Peptidase_S51 PF03575.12 CCF40137.1 - 0.0013 18.4 0.0 0.002 17.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S51 DUF2457 PF10446.4 CCF40138.1 - 1.4e-144 482.2 28.7 1.4e-144 482.2 19.9 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF2457) BUD22 PF09073.5 CCF40138.1 - 4.8e-05 22.6 13.7 4.8e-05 22.6 9.5 2.6 3 0 0 3 3 3 1 BUD22 TFIIA PF03153.8 CCF40138.1 - 0.0011 19.0 22.6 0.002 18.0 15.7 1.5 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.7 CCF40138.1 - 2.7 5.8 31.2 5 4.9 21.7 1.4 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.10 CCF40138.1 - 3 6.3 7.9 4.4 5.8 5.5 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Astro_capsid PF03115.9 CCF40138.1 - 7.7 4.6 11.1 12 3.9 7.7 1.3 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Arf PF00025.16 CCF40139.1 - 4.4e-50 169.3 0.0 5.5e-50 169.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 CCF40139.1 - 1.6e-08 33.6 0.0 2.4e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Ras PF00071.17 CCF40139.1 - 9.6e-05 21.8 0.0 0.00013 21.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF40139.1 - 0.00011 22.7 0.0 0.00014 22.3 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 CCF40139.1 - 0.0073 15.7 0.0 0.0086 15.5 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 CCF40139.1 - 0.0082 15.3 0.0 0.011 14.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF3336 PF11815.3 CCF40140.1 - 5.6e-54 181.6 4.8 8.9e-54 180.9 3.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 CCF40140.1 - 1.3e-22 80.7 0.0 1.3e-20 74.2 0.0 2.5 2 0 0 2 2 2 2 Patatin-like phospholipase DnaJ PF00226.26 CCF40141.1 - 1.8e-17 62.8 1.4 7.3e-17 60.8 1.0 2.0 1 1 0 1 1 1 1 DnaJ domain 7tm_1 PF00001.16 CCF40141.1 - 0.083 12.0 0.1 1.3 8.0 0.0 2.2 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) OST3_OST6 PF04756.8 CCF40141.1 - 0.094 12.2 0.1 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 OST3 / OST6 family IncA PF04156.9 CCF40141.1 - 0.4 10.2 3.1 0.26 10.8 0.5 1.9 2 0 0 2 2 2 0 IncA protein ETRAMP PF09716.5 CCF40141.1 - 0.96 9.4 3.2 0.85 9.6 0.7 2.1 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Fungal_trans PF04082.13 CCF40142.1 - 6e-31 107.2 0.0 8.9e-31 106.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF40142.1 - 5.2e-09 35.8 9.5 8.2e-09 35.2 6.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PROL5-SMR PF15621.1 CCF40144.1 - 0.04 14.3 1.9 0.04 14.3 1.3 2.0 2 1 0 2 2 2 0 Proline-rich submaxillary gland androgen-regulated family GSDH PF07995.6 CCF40145.1 - 0.00061 18.9 0.6 0.0024 17.0 0.4 2.2 1 1 0 1 1 1 1 Glucose / Sorbosone dehydrogenase SGL PF08450.7 CCF40145.1 - 0.018 14.3 0.0 0.19 11.0 0.0 2.3 2 1 0 2 2 2 0 SMP-30/Gluconolaconase/LRE-like region Lactonase PF10282.4 CCF40145.1 - 0.086 11.8 0.1 9.9 5.1 0.0 2.9 2 1 1 3 3 3 0 Lactonase, 7-bladed beta-propeller GFA PF04828.9 CCF40146.1 - 1.4e-14 53.8 6.4 6.3e-09 35.6 0.0 2.6 3 0 0 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme zf-ribbon_3 PF13248.1 CCF40146.1 - 0.0081 15.3 6.1 0.13 11.4 0.1 3.2 3 0 0 3 3 3 2 zinc-ribbon domain zf-NADH-PPase PF09297.6 CCF40146.1 - 0.01 15.3 0.1 0.01 15.3 0.1 3.0 5 0 0 5 5 5 1 NADH pyrophosphatase zinc ribbon domain Nudix_N_2 PF14803.1 CCF40146.1 - 0.013 15.1 4.2 1.5 8.6 0.1 3.4 3 0 0 3 3 3 0 Nudix N-terminal NOB1_Zn_bind PF08772.6 CCF40146.1 - 0.04 13.7 0.6 8.2 6.3 0.1 2.9 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like 2OG-FeII_Oxy_2 PF13532.1 CCF40147.1 - 1.2e-35 123.1 0.0 1.7e-35 122.6 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-GRF PF06839.7 CCF40147.1 - 2.2e-10 40.2 7.0 4.1e-10 39.4 4.9 1.4 1 0 0 1 1 1 1 GRF zinc finger 2OG-FeII_Oxy PF03171.15 CCF40147.1 - 0.0074 16.5 0.0 0.019 15.2 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily WD40 PF00400.27 CCF40148.1 - 5.8e-29 98.8 12.4 6e-10 38.6 0.0 6.5 7 0 0 7 7 7 6 WD domain, G-beta repeat BBS2_Mid PF14783.1 CCF40148.1 - 0.013 15.2 0.0 0.22 11.3 0.0 2.7 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region DEAD PF00270.24 CCF40149.1 - 1.5e-40 138.4 0.0 3.4e-40 137.2 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF40149.1 - 2.5e-21 75.3 0.1 5.7e-21 74.1 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 CCF40149.1 - 0.11 12.6 0.0 0.38 10.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain Mito_carr PF00153.22 CCF40155.1 - 5.6e-61 202.2 3.8 1.9e-24 85.1 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L18e PF00828.14 CCF40156.1 - 6.5e-24 84.7 0.0 6.5e-24 84.7 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L18e/L15 FtsJ PF01728.14 CCF40157.1 - 6.2e-22 78.4 0.1 7.7e-22 78.1 0.1 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase OSR1_C PF12202.3 CCF40158.1 - 0.12 12.0 0.2 0.21 11.2 0.1 1.4 1 0 0 1 1 1 0 Oxidative-stress-responsive kinase 1 C terminal 7tm_2 PF00002.19 CCF40159.1 - 3.4e-09 36.1 10.2 3.4e-09 36.1 7.0 1.9 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.6 CCF40159.1 - 5e-07 28.9 7.8 5e-07 28.9 5.4 1.8 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor Git3 PF11710.3 CCF40159.1 - 2.3e-06 27.2 8.4 3.9e-06 26.5 5.8 1.3 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 ADH_zinc_N PF00107.21 CCF40160.1 - 3e-13 49.4 0.1 7.3e-13 48.2 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF40160.1 - 7e-09 35.4 0.2 2e-08 33.9 0.1 1.7 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain NmrA PF05368.8 CCF40161.1 - 3e-25 88.8 0.4 3.6e-25 88.5 0.3 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF40161.1 - 2.3e-15 57.0 0.2 3.1e-15 56.6 0.1 1.2 1 0 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 CCF40161.1 - 2.8e-07 29.8 1.4 3.6e-06 26.2 0.1 2.0 2 0 0 2 2 2 1 Saccharopine dehydrogenase Semialdhyde_dh PF01118.19 CCF40161.1 - 0.02 15.1 0.0 0.039 14.2 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_7 PF13241.1 CCF40161.1 - 0.036 14.3 0.2 0.09 13.0 0.0 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding Kinesin PF00225.18 CCF40162.1 - 3.4e-34 118.0 0.0 3.8e-34 117.8 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain AAA_22 PF13401.1 CCF40162.1 - 0.083 13.0 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AdoHcyase_NAD PF00670.16 CCF40162.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Pyr_redox_2 PF07992.9 CCF40163.1 - 3.2e-06 27.1 0.1 0.001 18.9 0.3 2.9 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF40163.1 - 8e-05 22.7 0.5 0.0075 16.3 0.6 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF40163.1 - 0.00013 20.9 2.4 0.021 13.6 0.8 2.3 2 0 0 2 2 2 2 FAD binding domain FAD_binding_3 PF01494.14 CCF40163.1 - 0.0026 16.8 0.3 0.0055 15.7 0.1 1.6 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.9 CCF40163.1 - 0.0027 16.2 0.6 0.0043 15.5 0.4 1.3 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.1 CCF40163.1 - 0.0043 17.0 0.2 0.013 15.5 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 CCF40163.1 - 0.0066 15.3 0.2 0.58 9.0 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) AlaDh_PNT_C PF01262.16 CCF40163.1 - 0.016 14.7 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.19 CCF40163.1 - 0.046 12.6 0.9 0.23 10.2 0.1 2.1 2 1 0 2 2 2 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 CCF40163.1 - 0.047 12.5 0.1 0.047 12.5 0.0 1.9 3 0 0 3 3 3 0 Lycopene cyclase protein DRTGG PF07085.7 CCF40163.1 - 0.11 12.1 0.1 0.28 10.7 0.0 1.7 2 0 0 2 2 2 0 DRTGG domain GIDA PF01134.17 CCF40163.1 - 0.13 11.1 0.7 0.45 9.3 0.1 2.1 3 0 0 3 3 3 0 Glucose inhibited division protein A Pyr_redox PF00070.22 CCF40163.1 - 0.13 12.6 0.0 0.29 11.5 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.13 CCF40163.1 - 0.16 12.0 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain LCAT PF02450.10 CCF40164.1 - 1.3e-98 330.5 0.1 1.7e-98 330.1 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Lipase_2 PF01674.13 CCF40164.1 - 0.0039 16.5 0.0 0.007 15.6 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 2) Abhydrolase_5 PF12695.2 CCF40164.1 - 0.019 14.6 0.0 0.046 13.4 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF40164.1 - 0.022 14.6 0.2 0.066 13.0 0.0 1.9 2 1 0 2 2 2 0 Alpha/beta hydrolase family DUF1778 PF08681.6 CCF40164.1 - 0.097 12.5 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1778) TFIIB PF00382.14 CCF40167.1 - 8.2e-33 112.0 0.9 6.3e-19 67.5 0.1 2.7 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.8 CCF40167.1 - 1.3e-22 79.8 0.5 1.3e-22 79.8 0.3 3.6 3 0 0 3 3 3 1 Brf1-like TBP-binding domain Cyclin_N PF00134.18 CCF40167.1 - 1.5e-10 40.7 0.9 7.8e-05 22.2 0.0 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Rtf2 PF04641.7 CCF40167.1 - 0.018 14.2 0.4 0.018 14.2 0.3 2.6 3 1 1 4 4 4 0 Rtf2 RING-finger Cut8_N PF14482.1 CCF40167.1 - 1.9 8.5 8.5 0.062 13.3 0.5 2.5 2 0 0 2 2 2 0 Cut8 proteasome-binding domain DUF3123 PF11321.3 CCF40167.1 - 2.1 8.6 6.3 8.5 6.7 4.3 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3123) DUF1349 PF07081.6 CCF40168.1 - 1.3e-19 70.2 0.0 1.5e-19 70.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) MARVEL PF01284.18 CCF40169.1 - 0.0037 17.1 10.2 0.0056 16.5 7.1 1.3 1 0 0 1 1 1 1 Membrane-associating domain Peptidase_S24 PF00717.18 CCF40170.1 - 5.1e-08 32.4 0.0 7.5e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase S24-like ERO1 PF04137.10 CCF40172.1 - 1.2e-136 455.4 0.0 1.5e-136 455.1 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Glutaredoxin PF00462.19 CCF40172.1 - 0.014 15.3 0.0 0.045 13.7 0.0 1.8 1 0 0 1 1 1 0 Glutaredoxin Alk_phosphatase PF00245.15 CCF40173.1 - 5.3e-70 236.2 0.2 8.1e-70 235.6 0.1 1.3 1 0 0 1 1 1 1 Alkaline phosphatase Phosphodiest PF01663.17 CCF40173.1 - 1.9e-07 30.7 0.0 3.4e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 CCF40173.1 - 2.6e-07 30.1 0.1 4.5e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Sulfatase DUF229 PF02995.12 CCF40173.1 - 0.00032 19.2 0.3 0.00059 18.3 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF1501 PF07394.7 CCF40173.1 - 0.0059 15.4 0.1 0.0089 14.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1501) FTA4 PF13093.1 CCF40173.1 - 0.19 11.1 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Zn_clus PF00172.13 CCF40174.1 - 0.0014 18.5 7.7 0.0035 17.2 5.4 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF912 PF06024.7 CCF40175.1 - 0.077 13.0 0.1 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) UbiA PF01040.13 CCF40176.1 - 1.4e-27 96.5 19.4 2.3e-27 95.8 13.4 1.3 1 1 0 1 1 1 1 UbiA prenyltransferase family PQ-loop PF04193.9 CCF40176.1 - 0.035 13.6 0.3 0.13 11.7 0.2 2.1 1 0 0 1 1 1 0 PQ loop repeat DUF4006 PF13179.1 CCF40176.1 - 3.9 7.1 5.2 5 6.7 1.1 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF4006) Zn_clus PF00172.13 CCF40177.1 - 2.1e-06 27.5 10.4 4.4e-06 26.5 7.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Occludin_ELL PF07303.8 CCF40177.1 - 0.15 12.8 0.0 0.24 12.1 0.0 1.4 1 0 0 1 1 1 0 Occludin homology domain LTXXQ PF07813.7 CCF40179.1 - 0.061 13.7 0.1 0.089 13.2 0.1 1.3 1 0 0 1 1 1 0 LTXXQ motif family protein TEX13 PF15186.1 CCF40180.1 - 0.1 12.1 0.1 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family FF PF01846.14 CCF40181.1 - 1.8e-52 175.0 11.5 1.9e-15 56.5 0.2 7.0 6 1 0 6 6 6 5 FF domain WW PF00397.21 CCF40181.1 - 1.4e-19 69.5 15.7 7.9e-11 41.6 2.8 2.7 2 0 0 2 2 2 2 WW domain RhoGAP PF00620.22 CCF40181.1 - 1.3 8.5 7.8 0.22 11.1 0.3 2.7 3 0 0 3 3 3 0 RhoGAP domain Glu-tRNAGln PF02686.10 CCF40182.1 - 0.081 12.7 0.5 0.65 9.8 0.0 2.3 2 0 0 2 2 2 0 Glu-tRNAGln amidotransferase C subunit SKG6 PF08693.5 CCF40183.1 - 0.0028 16.9 0.3 0.0028 16.9 0.2 2.8 3 0 0 3 3 3 1 Transmembrane alpha-helix domain Protocadherin PF08374.6 CCF40183.1 - 0.0054 16.3 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 Protocadherin Glycophorin_A PF01102.13 CCF40183.1 - 0.0077 15.9 10.5 0.025 14.3 5.8 2.5 1 1 1 2 2 2 1 Glycophorin A DUF4448 PF14610.1 CCF40183.1 - 0.031 13.7 0.1 0.11 11.9 0.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4448) ATG22 PF11700.3 CCF40183.1 - 0.073 11.5 0.0 0.076 11.4 0.0 1.1 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like DGF-1_5 PF11038.3 CCF40183.1 - 0.12 11.6 2.0 0.14 11.3 1.4 1.2 1 1 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 PALP PF00291.20 CCF40185.1 - 4.8e-59 200.0 2.7 5.4e-59 199.9 1.9 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CoA_transf_3 PF02515.12 CCF40186.1 - 2.6e-27 95.3 0.0 1.2e-26 93.0 0.0 1.9 2 0 0 2 2 2 1 CoA-transferase family III Peptidase_M20 PF01546.23 CCF40187.1 - 1.3e-09 37.7 0.1 2e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 ADH_zinc_N PF00107.21 CCF40188.1 - 2.7e-14 52.8 0.1 4.6e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF40188.1 - 0.0002 21.0 0.0 0.0004 20.1 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain KR PF08659.5 CCF40190.1 - 5.2e-58 195.6 0.9 1.1e-57 194.6 0.6 1.6 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 CCF40190.1 - 1.8e-45 154.8 0.6 1.8e-45 154.8 0.4 2.0 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N PF00107.21 CCF40190.1 - 1.3e-18 66.7 0.0 3.6e-18 65.3 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF40190.1 - 2.2e-13 51.2 0.0 6.6e-13 49.6 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.20 CCF40190.1 - 1.9e-07 31.2 0.1 7.4e-07 29.3 0.0 2.1 2 0 0 2 2 2 1 Phosphopantetheine attachment site ADH_N PF08240.7 CCF40190.1 - 0.0026 17.5 1.1 0.0062 16.2 0.1 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Chorismate_bind PF00425.13 CCF40191.1 - 4.1e-65 219.6 0.0 1.2e-64 218.1 0.0 1.8 1 1 0 1 1 1 1 chorismate binding enzyme GATase PF00117.23 CCF40191.1 - 6.4e-25 87.7 0.0 2.1e-24 86.0 0.0 1.8 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.8 CCF40191.1 - 1.7e-15 57.2 0.0 4e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.8 CCF40191.1 - 6.1e-05 22.5 0.0 0.00014 21.3 0.0 1.6 1 1 0 1 1 1 1 Peptidase C26 DUF1895 PF08988.5 CCF40192.1 - 0.12 12.3 0.1 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1895) TrkH PF02386.11 CCF40193.1 - 2.1e-82 276.5 1.3 2.7e-82 276.2 0.9 1.1 1 0 0 1 1 1 1 Cation transport protein zf-C2H2_6 PF13912.1 CCF40195.1 - 0.013 15.4 0.2 0.045 13.6 0.1 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_4 PF13894.1 CCF40195.1 - 0.056 13.8 5.3 0.44 11.0 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CCF40195.1 - 0.079 13.2 4.0 0.14 12.5 2.0 2.0 2 0 0 2 2 2 0 Zinc-finger double domain zf-Di19 PF05605.7 CCF40195.1 - 0.79 9.8 0.1 0.79 9.8 0.1 2.9 4 0 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-SAP30 PF13866.1 CCF40196.1 - 0.25 11.0 2.3 0.36 10.5 1.6 1.4 1 0 0 1 1 1 0 SAP30 zinc-finger Ecm33 PF12454.3 CCF40196.1 - 2.2 8.2 7.0 0.25 11.2 1.9 1.7 2 0 0 2 2 2 0 GPI-anchored cell wall organization protein CMD PF02627.15 CCF40197.1 - 8e-19 67.2 0.1 1.6e-18 66.2 0.1 1.5 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family TraC PF07820.7 CCF40197.1 - 0.16 12.1 1.3 0.97 9.6 0.1 2.5 3 0 0 3 3 3 0 TraC-like protein Acetyltransf_1 PF00583.19 CCF40198.1 - 6.1e-11 42.2 0.1 9.7e-11 41.5 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 CCF40198.1 - 1.1e-08 35.2 0.4 1.3e-08 34.9 0.3 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 CCF40198.1 - 2e-08 34.2 0.0 2.7e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 CCF40198.1 - 2.8e-07 30.4 0.2 8e-07 28.9 0.1 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 CCF40198.1 - 1.9e-06 27.9 0.0 2.3e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_6 PF13480.1 CCF40198.1 - 0.00045 20.1 0.4 0.00063 19.7 0.3 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF3749 PF12568.3 CCF40198.1 - 0.015 14.9 0.2 0.02 14.4 0.1 1.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Tyrosinase PF00264.15 CCF40199.1 - 5.6e-47 160.7 0.8 7.2e-47 160.3 0.6 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase ECH PF00378.15 CCF40201.1 - 1.2e-13 50.7 0.0 2.1e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Formyl_trans_N PF00551.14 CCF40201.1 - 5.2e-12 45.6 0.0 3.7e-11 42.9 0.0 2.2 1 1 1 2 2 2 1 Formyl transferase Formyl_trans_C PF02911.13 CCF40201.1 - 1.4e-08 34.7 0.0 2.9e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain DUF2315 PF10231.4 CCF40201.1 - 0.085 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2315) DMPK_coil PF08826.5 CCF40202.1 - 0.015 15.1 1.0 0.035 14.0 0.1 2.1 2 0 0 2 2 2 0 DMPK coiled coil domain like Filament PF00038.16 CCF40202.1 - 0.052 13.0 1.1 0.23 10.9 0.0 1.8 1 1 0 2 2 2 0 Intermediate filament protein Phage_GPO PF05929.6 CCF40202.1 - 0.12 11.5 0.6 0.34 10.1 0.1 1.8 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF3759 PF12585.3 CCF40203.1 - 3.7e-41 138.9 6.2 4.8e-41 138.5 4.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) AvrRpt-cleavage PF05627.6 CCF40204.1 - 0.25 10.4 3.4 4.5 6.4 0.0 2.8 3 0 0 3 3 3 0 Cleavage site for pathogenic type III effector avirulence factor Avr IncA PF04156.9 CCF40206.1 - 9.4e-05 22.0 1.6 0.00012 21.7 1.1 1.2 1 0 0 1 1 1 1 IncA protein Tropomyosin_1 PF12718.2 CCF40206.1 - 0.024 14.4 2.7 0.038 13.8 1.9 1.3 1 0 0 1 1 1 0 Tropomyosin like Nup54 PF13874.1 CCF40206.1 - 0.94 9.1 9.2 1.7 8.2 6.4 1.5 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 NARP1 PF12569.3 CCF40208.1 - 0.049 12.3 2.9 2.1 6.9 1.6 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 BUD22 PF09073.5 CCF40208.1 - 1.1 8.2 18.5 1.8 7.5 12.8 1.2 1 0 0 1 1 1 0 BUD22 DUF3366 PF11846.3 CCF40209.1 - 0.0015 18.4 0.2 0.018 14.9 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3366) DUF4142 PF13628.1 CCF40209.1 - 0.039 13.9 0.6 0.11 12.5 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4142) CMAS PF02353.15 CCF40211.1 - 1.9e-13 50.0 0.0 2.7e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 CCF40211.1 - 8.9e-12 45.0 0.1 3.4e-11 43.1 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF40211.1 - 3.2e-10 40.5 0.0 4.4e-09 36.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF40211.1 - 2.1e-07 30.6 0.0 2.9e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF40211.1 - 2.8e-07 30.8 0.0 2.7e-06 27.6 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF40211.1 - 8.5e-07 29.3 0.0 2.6e-06 27.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF40211.1 - 7.5e-05 23.1 0.0 0.00053 20.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF40211.1 - 0.00027 20.9 0.0 0.00051 20.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 CCF40211.1 - 0.005 16.4 0.0 0.0077 15.7 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.7 CCF40211.1 - 0.012 14.9 0.0 0.03 13.7 0.0 1.6 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.1 CCF40211.1 - 0.014 15.1 0.0 0.028 14.0 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain DOT1 PF08123.8 CCF40211.1 - 0.03 13.6 0.0 0.051 12.8 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 RrnaAD PF00398.15 CCF40211.1 - 0.036 13.0 0.0 0.053 12.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase MTS PF05175.9 CCF40211.1 - 0.12 11.7 0.0 1.1 8.5 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase small domain DUF3012 PF11216.3 CCF40211.1 - 0.15 11.7 1.9 0.23 11.1 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3012) Lactamase_B PF00753.22 CCF40212.1 - 1.5e-07 31.3 1.8 5.3e-07 29.4 1.3 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CCF40212.1 - 4.1e-05 23.2 0.1 5.1e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain CENP-F_leu_zip PF10473.4 CCF40214.1 - 0.076 12.8 14.0 0.18 11.6 2.1 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF342 PF03961.8 CCF40214.1 - 0.14 10.5 2.5 0.19 10.1 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DASH_Spc19 PF08287.6 CCF40214.1 - 0.83 9.2 11.6 1.7 8.2 4.1 2.2 1 1 1 2 2 2 0 Spc19 Atg14 PF10186.4 CCF40214.1 - 2.8 6.7 7.6 11 4.8 5.4 1.7 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 UbiA PF01040.13 CCF40215.1 - 3.9e-18 65.6 11.5 5e-18 65.2 8.0 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family CBP PF12192.3 CCF40216.1 - 4.7 7.2 6.3 0.64 10.0 0.1 2.2 1 1 1 2 2 2 0 Fungal calcium binding protein YvbH_ext PF11724.3 CCF40218.1 - 0.15 11.7 0.5 0.27 10.9 0.4 1.4 1 0 0 1 1 1 0 YvbH-like oligomerisation region adh_short PF00106.20 CCF40219.1 - 1.3e-27 96.7 0.0 2.5e-27 95.8 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF40219.1 - 2.5e-10 40.3 0.0 7.1e-10 38.8 0.0 1.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF40219.1 - 5.6e-06 25.9 0.0 8.2e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF40219.1 - 1e-05 24.3 0.0 1.4e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short_C2 PF13561.1 CCF40219.1 - 0.00012 21.9 0.0 0.00019 21.2 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 CCF40219.1 - 0.00015 21.7 0.0 0.00031 20.7 0.0 1.6 1 1 0 1 1 1 1 NADH(P)-binding DUF1776 PF08643.5 CCF40219.1 - 0.0065 15.6 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) G6PD_C PF02781.11 CCF40221.1 - 4.9e-115 383.4 0.0 3.3e-113 377.4 0.0 2.1 1 1 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.17 CCF40221.1 - 4.9e-63 212.6 0.0 1e-62 211.6 0.0 1.5 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Solute_trans_a PF03619.11 CCF40223.1 - 1.1e-105 352.8 8.0 1.4e-105 352.5 5.5 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Glyco_hydro_92 PF07971.7 CCF40224.1 - 8.3e-57 192.9 0.0 9.8e-57 192.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 HSP70 PF00012.15 CCF40225.1 - 6.5e-39 133.3 0.3 4.1e-32 110.8 0.1 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 CCF40225.1 - 0.00042 19.0 0.1 0.00056 18.6 0.0 1.1 1 0 0 1 1 1 1 MreB/Mbl protein Methyltransf_4 PF02390.12 CCF40227.1 - 7.8e-53 178.4 0.0 9.7e-53 178.1 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 CCF40227.1 - 9.9e-05 22.8 0.0 0.00018 22.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF40227.1 - 0.00031 20.7 0.0 0.00065 19.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF40227.1 - 0.00038 20.8 0.0 0.003 18.0 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF40227.1 - 0.0018 18.5 0.1 0.0062 16.8 0.0 2.0 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_32 PF13679.1 CCF40227.1 - 0.0023 17.6 0.0 0.0043 16.7 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF40227.1 - 0.0023 18.3 0.0 0.012 16.1 0.0 2.2 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF40227.1 - 0.0036 16.8 0.0 0.0053 16.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain FmrO PF07091.6 CCF40227.1 - 0.004 16.1 0.0 0.012 14.5 0.0 1.7 2 0 0 2 2 2 1 Ribosomal RNA methyltransferase (FmrO) PCMT PF01135.14 CCF40227.1 - 0.016 14.7 0.1 0.061 12.8 0.0 1.9 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.9 CCF40227.1 - 0.02 14.2 0.0 0.033 13.5 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.15 CCF40227.1 - 0.054 12.5 0.0 0.11 11.6 0.0 1.5 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 CCF40227.1 - 0.11 12.1 0.0 0.28 10.9 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain PXA PF02194.10 CCF40228.1 - 1.8e-36 125.4 0.2 2.3e-36 125.1 0.2 1.1 1 0 0 1 1 1 1 PXA domain DUF1469 PF07332.6 CCF40228.1 - 0.17 11.5 3.8 0.31 10.7 2.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) Npa1 PF11707.3 CCF40229.1 - 3.7e-76 256.2 0.0 6e-76 255.5 0.0 1.3 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal FHA PF00498.21 CCF40230.1 - 4.9e-07 29.7 0.0 8.6e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 FHA domain DUF2486 PF10667.4 CCF40230.1 - 0.15 12.5 0.5 0.22 12.0 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) Glyco_hydro_18 PF00704.23 CCF40231.1 - 5.1e-11 42.6 1.4 1.9e-10 40.7 1.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 GHL6 PF14871.1 CCF40231.1 - 0.0076 16.2 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 Hypothetical glycosyl hydrolase 6 zf-Apc11 PF12861.2 CCF40233.1 - 5.1e-45 151.2 11.6 5.8e-45 151.0 8.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 CCF40233.1 - 1e-32 112.0 10.6 1.3e-32 111.7 7.4 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 CCF40233.1 - 9.6e-09 34.9 16.4 6.2e-08 32.3 11.4 2.3 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 CCF40233.1 - 2.3e-05 23.9 11.6 0.00055 19.5 8.0 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF40233.1 - 0.00011 21.7 13.6 0.00046 19.7 9.4 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CCF40233.1 - 0.00015 21.7 13.4 0.0011 18.9 9.3 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CCF40233.1 - 0.00031 20.5 4.0 0.00031 20.5 2.8 2.3 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.1 CCF40233.1 - 0.0011 18.4 3.3 0.0011 18.4 2.3 2.3 1 1 1 2 2 2 1 RING/Ubox like zinc-binding domain FANCL_C PF11793.3 CCF40233.1 - 0.004 17.0 16.9 0.1 12.5 11.7 3.1 1 1 0 1 1 1 1 FANCL C-terminal domain zf-RING_5 PF14634.1 CCF40233.1 - 0.0087 15.7 16.0 0.21 11.3 11.5 2.6 1 1 1 2 2 2 1 zinc-RING finger domain zf-HIT PF04438.11 CCF40233.1 - 0.015 14.9 3.4 0.053 13.1 0.7 2.4 2 0 0 2 2 2 0 HIT zinc finger zf-Nse PF11789.3 CCF40233.1 - 0.044 13.3 5.8 0.079 12.4 4.0 1.5 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF2256 PF10013.4 CCF40233.1 - 0.15 11.8 0.3 0.15 11.8 0.2 3.4 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) Opy2 PF09463.5 CCF40233.1 - 0.43 10.7 10.8 1.9 8.6 4.5 2.3 2 0 0 2 2 2 0 Opy2 protein zf-DBF PF07535.7 CCF40233.1 - 0.5 10.0 3.4 1.7 8.3 0.0 2.3 2 0 0 2 2 2 0 DBF zinc finger zinc-ribbons_6 PF07191.7 CCF40233.1 - 1.4 8.7 10.3 1 9.1 0.1 2.6 2 1 0 2 2 2 0 zinc-ribbons DUF329 PF03884.9 CCF40233.1 - 1.6 8.3 9.0 0.4 10.2 0.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF329) DZR PF12773.2 CCF40233.1 - 2.8 7.8 13.0 10 6.0 4.2 2.2 1 1 1 2 2 2 0 Double zinc ribbon zf-RING-like PF08746.6 CCF40233.1 - 3.1 7.8 13.9 17 5.5 9.6 2.2 1 1 0 1 1 1 0 RING-like domain zf-HC5HC2H PF13771.1 CCF40233.1 - 4 7.6 11.6 2.5 8.3 4.5 2.4 1 1 1 2 2 2 0 PHD-like zinc-binding domain RINGv PF12906.2 CCF40233.1 - 4.7 7.3 12.9 13 5.9 8.5 2.2 1 1 1 2 2 2 0 RING-variant domain zf-HC5HC2H_2 PF13832.1 CCF40233.1 - 6.3 6.8 11.0 2.8 8.0 4.1 2.2 1 1 1 2 2 2 0 PHD-zinc-finger like domain PHD PF00628.24 CCF40233.1 - 9.9 5.9 14.9 51 3.6 10.3 2.1 1 1 0 1 1 1 0 PHD-finger adh_short PF00106.20 CCF40235.1 - 2.1e-17 63.5 0.3 2.2e-15 56.9 0.0 2.6 2 1 0 2 2 2 2 short chain dehydrogenase KR PF08659.5 CCF40235.1 - 1.1e-05 25.1 0.1 5e-05 23.0 0.0 2.1 2 1 0 2 2 2 1 KR domain adh_short_C2 PF13561.1 CCF40235.1 - 0.0038 17.0 0.2 0.037 13.7 0.0 2.4 2 1 1 3 3 3 1 Enoyl-(Acyl carrier protein) reductase Pectate_lyase PF03211.8 CCF40236.1 - 5.8e-50 169.6 0.6 7.9e-50 169.2 0.4 1.1 1 0 0 1 1 1 1 Pectate lyase Glyco_hydro_16 PF00722.16 CCF40237.1 - 6.9e-13 48.2 1.5 9.3e-13 47.8 1.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 AMP-binding PF00501.23 CCF40238.1 - 2.6e-76 256.6 0.0 3.1e-76 256.4 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF40238.1 - 2e-15 57.4 0.2 5.6e-15 56.0 0.1 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Striatin PF08232.7 CCF40239.1 - 7.3e-37 126.7 3.9 7.3e-37 126.7 2.7 2.7 3 0 0 3 3 3 1 Striatin family WD40 PF00400.27 CCF40239.1 - 6e-32 108.3 15.9 6.1e-08 32.2 0.0 7.7 7 1 0 7 7 7 5 WD domain, G-beta repeat Hid1 PF12722.2 CCF40239.1 - 1.6 6.3 9.0 2.5 5.6 6.2 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ctr PF04145.10 CCF40239.1 - 5 7.1 5.5 18 5.3 3.8 1.9 1 0 0 1 1 1 0 Ctr copper transporter family Glyco_transf_15 PF01793.11 CCF40239.1 - 6.9 5.5 8.2 13 4.6 5.7 1.3 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase Plasmodium_Vir PF05795.6 CCF40239.1 - 8.1 5.5 5.4 1.3 8.1 1.0 1.7 2 0 0 2 2 2 0 Plasmodium vivax Vir protein ketoacyl-synt PF00109.21 CCF40242.1 - 1.2e-28 100.2 2.7 1.4e-28 100.0 0.1 2.3 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain DUF3877 PF12993.2 CCF40243.1 - 0.034 13.7 0.1 0.038 13.5 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3877) Pox_A_type_inc PF04508.7 CCF40244.1 - 0.00087 18.8 2.2 0.00087 18.8 1.5 4.8 4 1 0 4 4 4 1 Viral A-type inclusion protein repeat CCDC-167 PF15188.1 CCF40244.1 - 0.098 12.6 3.6 0.34 10.8 2.5 1.9 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 FUSC PF04632.7 CCF40244.1 - 1.5 7.1 7.0 2 6.7 4.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family ADIP PF11559.3 CCF40244.1 - 4.6 7.1 14.0 2.5 7.9 4.0 2.6 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding TSC22 PF01166.13 CCF40244.1 - 5.6 7.0 7.0 8.9 6.3 0.5 3.3 3 0 0 3 3 3 0 TSC-22/dip/bun family Myticin-prepro PF10690.4 CCF40245.1 - 4.6 7.3 9.4 4.9 7.2 6.5 1.2 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel adh_short PF00106.20 CCF40246.1 - 3.1e-15 56.5 0.0 5e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.1 CCF40246.1 - 0.0029 17.6 0.5 0.0079 16.2 0.1 1.7 2 0 0 2 2 2 1 NADH(P)-binding KR PF08659.5 CCF40246.1 - 0.0093 15.6 0.2 0.035 13.7 0.1 2.1 1 1 0 1 1 1 1 KR domain LytR_C PF13399.1 CCF40246.1 - 0.072 13.4 0.2 9.5 6.6 0.0 2.4 2 0 0 2 2 2 0 LytR cell envelope-related transcriptional attenuator HhH-GPD PF00730.20 CCF40248.1 - 4.7e-13 49.3 0.0 8.5e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein AT_hook PF02178.14 CCF40248.1 - 0.11 12.2 6.5 0.54 10.1 4.5 2.3 1 0 0 1 1 1 0 AT hook motif Pkinase PF00069.20 CCF40250.1 - 2.1e-52 177.8 0.0 2.7e-52 177.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF40250.1 - 1.1e-23 83.6 0.0 3.3e-23 82.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 CCF40250.1 - 0.029 13.1 0.1 0.047 12.4 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase RIO1 PF01163.17 CCF40250.1 - 0.058 12.7 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.1 CCF40250.1 - 0.15 10.9 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like HET PF06985.6 CCF40252.1 - 3.1e-21 75.9 3.9 5.5e-17 62.2 0.1 2.1 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Transp_cyt_pur PF02133.10 CCF40253.1 - 2.8e-153 510.6 31.8 3.2e-153 510.4 22.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Pkinase PF00069.20 CCF40254.1 - 5.5e-59 199.4 0.0 7.7e-59 198.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF40254.1 - 6e-20 71.3 0.0 3.3e-19 68.9 0.0 2.1 2 1 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 CCF40254.1 - 0.063 12.0 0.1 0.094 11.4 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PRA1 PF03208.14 CCF40255.1 - 7.6e-06 25.3 2.0 1.3e-05 24.5 1.4 1.3 1 0 0 1 1 1 1 PRA1 family protein Corona_nucleoca PF00937.13 CCF40255.1 - 0.89 8.4 8.9 1.5 7.6 6.1 1.4 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Ribosomal_60s PF00428.14 CCF40255.1 - 1.1 9.6 5.8 3.3 8.1 4.0 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF1509 PF07420.6 CCF40255.1 - 1.7 7.8 18.0 0.63 9.2 10.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1509) CTP_transf_2 PF01467.21 CCF40256.1 - 0.027 14.5 0.0 0.26 11.3 0.0 2.4 3 0 0 3 3 3 0 Cytidylyltransferase Glycos_transf_1 PF00534.15 CCF40257.1 - 4.4e-34 117.3 0.0 1.1e-32 112.7 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 CCF40257.1 - 2.9e-09 37.2 0.5 9.8e-09 35.5 0.1 1.8 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.1 CCF40257.1 - 7.1e-08 32.6 0.0 1.8e-06 28.1 0.0 2.7 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 CCF40257.1 - 2.1e-07 30.8 0.0 1.3e-06 28.2 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.1 CCF40257.1 - 0.00057 20.1 0.0 0.0012 19.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 ECH PF00378.15 CCF40258.1 - 4.3e-19 68.6 0.0 5.5e-19 68.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Peptidase_S49 PF01343.13 CCF40258.1 - 0.0012 18.5 0.0 0.47 10.2 0.0 2.4 2 0 0 2 2 2 2 Peptidase family S49 RabGAP-TBC PF00566.13 CCF40259.1 - 1.8e-49 168.1 0.1 2.8e-49 167.4 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain zf-C2H2 PF00096.21 CCF40260.1 - 0.00035 20.7 3.7 0.1 12.9 0.4 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF40260.1 - 0.0004 20.5 4.6 0.12 12.7 0.1 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CCF40260.1 - 0.0033 17.6 0.6 0.015 15.5 0.0 2.1 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_6 PF13912.1 CCF40260.1 - 0.009 15.8 2.3 2.5 8.1 0.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-ribbon_3 PF13248.1 CCF40260.1 - 0.015 14.4 0.3 0.026 13.7 0.2 1.4 1 0 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 CCF40260.1 - 0.084 12.4 0.1 0.18 11.3 0.1 1.5 1 0 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 CCF40260.1 - 0.099 12.3 0.1 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 zinc-ribbon domain zf-TFIIB PF13453.1 CCF40260.1 - 0.11 11.7 0.3 0.2 10.8 0.2 1.5 1 0 0 1 1 1 0 Transcription factor zinc-finger Zn-ribbon_8 PF09723.5 CCF40260.1 - 0.32 10.9 0.2 0.32 10.9 0.1 2.0 2 0 0 2 2 2 0 Zinc ribbon domain Glyco_hydro_43 PF04616.9 CCF40261.1 - 1.1e-35 123.1 1.4 1.4e-35 122.8 1.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Pantoate_ligase PF02569.10 CCF40263.1 - 3.5e-76 255.6 0.0 7.3e-76 254.5 0.0 1.5 1 1 0 1 1 1 1 Pantoate-beta-alanine ligase Acyltransferase PF01553.16 CCF40264.1 - 1.3e-16 60.1 0.0 2.7e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase SGL PF08450.7 CCF40265.1 - 1e-12 47.9 0.0 4.3e-12 45.9 0.0 1.8 1 1 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region NHL PF01436.16 CCF40265.1 - 0.033 14.1 0.6 10 6.3 0.0 3.7 4 0 0 4 4 4 0 NHL repeat HET PF06985.6 CCF40266.1 - 0.0036 17.4 0.0 0.0098 16.0 0.0 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) COesterase PF00135.23 CCF40267.1 - 2.3e-70 237.8 0.0 3.3e-70 237.3 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF40267.1 - 7.8e-07 28.8 0.4 0.00015 21.3 0.0 2.9 3 0 0 3 3 3 2 alpha/beta hydrolase fold MR_MLE_C PF13378.1 CCF40268.1 - 2.7e-19 69.1 0.0 7.6e-19 67.7 0.0 1.8 2 0 0 2 2 2 1 Enolase C-terminal domain-like MR_MLE PF01188.16 CCF40268.1 - 2.1e-13 50.5 0.0 9.9e-13 48.4 0.0 2.0 2 0 0 2 2 2 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MAAL_C PF07476.6 CCF40268.1 - 0.02 13.8 0.0 0.033 13.1 0.0 1.3 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus MR_MLE_N PF02746.11 CCF40268.1 - 0.035 14.1 0.0 0.1 12.6 0.0 1.7 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Methyltransf_16 PF10294.4 CCF40269.1 - 5.3e-11 42.2 0.0 7.4e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.8 CCF40269.1 - 0.0033 16.5 0.0 0.0059 15.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Vps39_2 PF10367.4 CCF40270.1 - 4.4e-09 36.4 0.0 5.6e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 CorC_HlyC PF03471.12 CCF40270.1 - 0.022 14.5 0.1 0.037 13.8 0.0 1.4 1 1 0 1 1 1 0 Transporter associated domain DUF3348 PF11828.3 CCF40270.1 - 0.077 12.3 0.2 0.13 11.6 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3348) E1-E2_ATPase PF00122.15 CCF40272.1 - 6e-51 172.6 0.1 6e-51 172.6 0.0 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CCF40272.1 - 1.2e-45 155.3 5.9 2.3e-45 154.3 4.1 1.5 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CCF40272.1 - 1.9e-29 103.6 0.2 2.3e-28 100.0 0.1 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF40272.1 - 3e-19 68.7 0.0 7.8e-19 67.4 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 CCF40272.1 - 1.5e-14 54.6 0.0 3e-14 53.6 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CCF40272.1 - 0.0007 19.2 0.4 0.0012 18.4 0.3 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Glycophorin_A PF01102.13 CCF40272.1 - 0.033 13.9 0.5 0.12 12.2 0.0 2.2 2 0 0 2 2 2 0 Glycophorin A UDG PF03167.14 CCF40275.1 - 4.5e-26 91.1 0.3 7.2e-26 90.4 0.1 1.4 2 0 0 2 2 2 1 Uracil DNA glycosylase superfamily DUF1708 PF08101.6 CCF40277.1 - 5.6e-161 536.0 0.0 8.2e-161 535.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) Sel1 PF08238.7 CCF40278.1 - 9.7e-27 92.8 24.3 7.4e-05 23.2 0.4 8.0 8 0 0 8 8 8 6 Sel1 repeat TPR_11 PF13414.1 CCF40278.1 - 0.0079 15.8 0.0 0.0079 15.8 0.0 2.5 3 1 0 3 3 3 1 TPR repeat CcmD PF04995.9 CCF40278.1 - 0.89 9.3 3.5 1.7 8.4 2.4 1.4 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) O-FucT PF10250.4 CCF40280.1 - 3.7e-05 23.0 0.0 0.0011 18.1 0.0 2.6 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase DUF4478 PF14793.1 CCF40280.1 - 0.1 12.1 0.1 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4478) Galactosyl_T PF01762.16 CCF40280.1 - 0.12 12.0 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Galactosyltransferase FMO-like PF00743.14 CCF40281.1 - 2.4e-31 108.5 0.0 2.8e-20 72.0 0.0 3.0 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 CCF40281.1 - 2.2e-12 47.4 0.0 1.5e-11 44.7 0.0 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF40281.1 - 5.7e-07 29.4 0.1 2.1e-06 27.6 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 CCF40281.1 - 2.2e-06 27.5 0.1 8.2e-05 22.4 0.1 2.9 2 1 0 2 2 2 1 FAD-NAD(P)-binding K_oxygenase PF13434.1 CCF40281.1 - 6e-05 22.1 0.4 0.0078 15.1 0.0 3.0 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 CCF40281.1 - 0.00011 22.1 0.0 2 8.2 0.1 3.2 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF40281.1 - 0.0049 15.8 0.9 0.022 13.6 0.2 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.9 CCF40281.1 - 0.033 12.6 0.3 0.054 11.9 0.2 1.3 1 0 0 1 1 1 0 HI0933-like protein OCD_Mu_crystall PF02423.10 CCF40281.1 - 0.034 12.9 0.2 0.051 12.3 0.1 1.2 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family Semialdhyde_dh PF01118.19 CCF40281.1 - 0.042 14.1 0.0 0.25 11.6 0.0 2.2 3 0 0 3 3 2 0 Semialdehyde dehydrogenase, NAD binding domain Thi4 PF01946.12 CCF40281.1 - 0.14 11.2 0.1 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Thi4 family adh_short PF00106.20 CCF40283.1 - 4.5e-07 29.9 0.0 8.4e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF40283.1 - 5.5e-06 26.3 0.0 7.9e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF904 PF06005.7 CCF40283.1 - 0.062 13.5 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF904) DUF1777 PF08648.7 CCF40284.1 - 1.2e-19 70.7 85.5 1.2e-12 47.9 59.3 2.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1777) Doppel PF11466.3 CCF40285.1 - 1.1 8.9 2.7 2.3 7.8 0.7 2.0 2 0 0 2 2 2 0 Prion-like protein Doppel Abhydrolase_5 PF12695.2 CCF40286.1 - 8.8e-07 28.7 0.0 1.5e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 CCF40286.1 - 1.5e-06 27.9 0.2 1.3e-05 24.9 0.2 2.0 1 1 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.9 CCF40286.1 - 6.5e-06 25.5 0.0 8.3e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 Putative serine esterase (DUF676) UPF0227 PF05728.7 CCF40286.1 - 4e-05 23.4 0.1 5.1e-05 23.0 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Abhydrolase_6 PF12697.2 CCF40286.1 - 6.2e-05 22.9 0.4 0.00021 21.2 0.3 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF40286.1 - 0.00015 21.4 0.0 0.00024 20.7 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.8 CCF40286.1 - 0.00071 19.2 0.0 0.00089 18.8 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Lipase_3 PF01764.20 CCF40286.1 - 0.0015 18.1 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Thioesterase PF00975.15 CCF40286.1 - 0.0056 16.9 0.2 0.0094 16.1 0.1 1.4 1 1 0 1 1 1 1 Thioesterase domain DUF915 PF06028.6 CCF40286.1 - 0.0061 15.6 0.1 0.85 8.6 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) DUF2305 PF10230.4 CCF40286.1 - 0.007 15.8 0.1 0.0089 15.4 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) DUF3089 PF11288.3 CCF40286.1 - 0.039 13.1 0.0 0.057 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) CHASE2 PF05226.6 CCF40286.1 - 0.094 11.9 0.0 0.13 11.5 0.0 1.4 1 1 0 1 1 1 0 CHASE2 domain Herpes_pp85 PF04637.7 CCF40286.1 - 0.15 10.3 0.0 0.2 9.9 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) DUF2974 PF11187.3 CCF40286.1 - 0.15 11.3 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) DUF900 PF05990.7 CCF40286.1 - 0.17 11.1 0.8 0.8 8.9 0.5 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Zip PF02535.17 CCF40288.1 - 6.3e-56 189.6 4.3 1.1e-55 188.9 2.9 1.3 1 1 0 1 1 1 1 ZIP Zinc transporter CTD_bind PF04818.8 CCF40289.1 - 2.8e-06 27.4 0.0 5.2e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase II-binding domain. DUF936 PF06075.7 CCF40289.1 - 3 6.6 8.0 4.1 6.2 5.5 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) B56 PF01603.15 CCF40290.1 - 3.6e-174 579.1 4.7 4.6e-174 578.8 3.3 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Tau95 PF09734.4 CCF40291.1 - 6.7e-63 212.8 0.0 8.7e-63 212.4 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit BCS1_N PF08740.6 CCF40292.1 - 1.2e-42 145.6 0.1 1.9e-42 145.0 0.1 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 CCF40292.1 - 2.2e-16 60.2 0.0 1.3e-07 31.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CCF40292.1 - 0.00017 22.3 0.1 0.00082 20.1 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 CCF40292.1 - 0.0011 18.3 0.0 0.0023 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 CCF40292.1 - 0.0046 16.0 0.0 0.0076 15.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 CCF40292.1 - 0.025 14.2 0.0 0.091 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) KaiC PF06745.8 CCF40292.1 - 0.057 12.5 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.1 CCF40292.1 - 0.088 12.7 0.2 0.49 10.3 0.1 2.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.1 CCF40292.1 - 0.11 12.0 2.1 0.1 12.1 0.3 1.7 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 CCF40292.1 - 0.14 12.4 0.5 0.48 10.7 0.3 2.0 1 1 0 1 1 1 0 AAA domain DUF3148 PF11347.3 CCF40293.1 - 0.01 15.4 0.0 0.021 14.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3148) DUF2562 PF10814.3 CCF40293.1 - 0.14 12.0 0.7 0.2 11.6 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2562) Xpo1 PF08389.7 CCF40294.1 - 3.8e-14 52.8 3.1 5.4e-14 52.3 1.3 1.8 2 0 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.14 CCF40294.1 - 6.4e-12 45.2 1.0 9e-12 44.7 0.1 1.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain Mem_trans PF03547.13 CCF40294.1 - 0.019 13.3 0.1 0.037 12.3 0.0 1.6 1 1 0 1 1 1 0 Membrane transport protein Aminotran_5 PF00266.14 CCF40295.1 - 1.1e-25 90.2 0.0 1.3e-25 89.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V B12-binding PF02310.14 CCF40295.1 - 1.8e-05 24.5 0.1 0.0025 17.6 0.0 2.6 2 1 1 3 3 3 1 B12 binding domain Aminotran_1_2 PF00155.16 CCF40295.1 - 9.9e-05 21.4 0.0 0.0002 20.4 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class I and II DUF521 PF04412.8 CCF40295.1 - 0.036 12.6 0.0 0.058 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF521) RusA PF05866.6 CCF40295.1 - 0.1 13.0 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Endodeoxyribonuclease RusA tRNA-synt_1b PF00579.20 CCF40297.1 - 2.8e-20 72.6 0.6 5.3e-20 71.7 0.0 1.8 2 1 0 2 2 2 1 tRNA synthetases class I (W and Y) BHD_3 PF10405.4 CCF40297.1 - 0.027 14.1 0.2 0.076 12.7 0.1 1.7 1 0 0 1 1 1 0 Rad4 beta-hairpin domain 3 WD40 PF00400.27 CCF40300.1 - 0.0001 22.0 9.3 0.0012 18.6 0.0 3.9 5 0 0 5 5 5 2 WD domain, G-beta repeat Hira PF07569.6 CCF40300.1 - 0.077 12.1 0.0 0.21 10.7 0.0 1.7 2 0 0 2 2 2 0 TUP1-like enhancer of split MFS_1 PF07690.11 CCF40302.1 - 7.2e-14 51.2 5.9 9.7e-14 50.8 4.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF40302.1 - 1.4e-05 23.8 2.8 3.3e-05 22.6 2.1 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.1 CCF40302.1 - 0.0068 14.8 2.3 0.0092 14.4 1.6 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein TRI12 PF06609.8 CCF40302.1 - 0.007 14.6 0.2 0.0089 14.2 0.1 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.2 CCF40302.1 - 0.043 13.6 0.1 0.088 12.6 0.1 1.6 1 1 0 1 1 1 0 MFS_1 like family Sugar_tr PF00083.19 CCF40303.1 - 3.2e-77 260.0 20.4 3.7e-77 259.8 14.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF40303.1 - 4.9e-29 101.1 25.7 7.8e-29 100.4 17.8 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily TypeIII_RM_meth PF12564.3 CCF40303.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Type III restriction/modification enzyme methylation subunit FA_hydroxylase PF04116.8 CCF40306.1 - 9.1e-19 67.9 12.3 1.1e-18 67.6 6.7 2.2 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily DUF829 PF05705.9 CCF40307.1 - 1.8e-45 155.5 0.0 2.4e-45 155.1 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) DUF1465 PF07323.7 CCF40308.1 - 0.057 12.9 0.1 0.076 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) DUF3847 PF12958.2 CCF40308.1 - 0.076 12.7 0.1 0.11 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) PBP PF01161.15 CCF40312.1 - 1.1e-19 70.7 0.0 1.3e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein HhH-GPD PF00730.20 CCF40313.1 - 1.5e-20 73.5 0.0 4e-20 72.0 0.0 1.8 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.1 CCF40313.1 - 1.3e-17 63.2 0.0 3.5e-17 61.8 0.0 1.8 1 1 0 1 1 1 1 NUDIX domain HHH PF00633.18 CCF40313.1 - 4.8e-05 22.8 0.1 0.0002 20.8 0.1 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif FeS PF04060.8 CCF40313.1 - 0.0066 16.0 1.9 0.015 14.8 1.3 1.7 1 0 0 1 1 1 1 Putative Fe-S cluster CDC45 PF02724.9 CCF40313.1 - 0.11 10.5 9.1 4.6 5.1 5.2 2.1 2 0 0 2 2 2 0 CDC45-like protein SGT1 PF07093.6 CCF40313.1 - 3.2 6.0 8.6 0.89 7.8 3.1 1.8 2 0 0 2 2 2 0 SGT1 protein Fungal_trans_2 PF11951.3 CCF40314.1 - 5.5e-09 35.0 0.4 7.1e-09 34.7 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain ABC_membrane PF00664.18 CCF40315.1 - 2.1e-69 234.0 40.1 7.8e-44 150.1 8.3 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 CCF40315.1 - 1.4e-13 51.2 0.0 1.3e-12 48.1 0.0 2.2 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.14 CCF40315.1 - 9.8e-06 24.9 0.6 0.071 12.3 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 CCF40315.1 - 6.3e-05 22.4 0.1 0.00021 20.7 0.1 1.9 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.1 CCF40315.1 - 0.0028 18.0 0.3 0.0046 17.3 0.2 1.3 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 CCF40315.1 - 0.0045 16.4 0.1 0.073 12.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CCF40315.1 - 0.006 16.7 0.1 0.034 14.2 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CCF40315.1 - 0.0075 17.0 0.1 0.016 15.9 0.1 1.7 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 CCF40315.1 - 0.015 14.5 0.0 0.026 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_10 PF12846.2 CCF40315.1 - 0.019 14.4 0.2 0.5 9.7 0.0 2.6 2 0 0 2 2 2 0 AAA-like domain AAA_21 PF13304.1 CCF40315.1 - 0.022 14.7 0.2 0.043 13.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain FliW PF02623.10 CCF40315.1 - 0.022 14.3 0.1 0.16 11.5 0.0 2.2 2 0 0 2 2 2 0 FliW protein AAA_16 PF13191.1 CCF40315.1 - 0.048 13.6 0.4 0.18 11.7 0.3 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.1 CCF40315.1 - 0.096 12.5 0.1 7.5 6.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 CCF40315.1 - 0.19 12.0 0.2 0.4 10.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain Hydant_A_N PF05378.8 CCF40316.1 - 1.5e-59 200.4 2.1 1e-57 194.4 0.0 2.1 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.13 CCF40316.1 - 5.6e-32 110.9 1.1 7.6e-32 110.5 0.2 1.6 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Nexin_C PF08628.7 CCF40317.1 - 1.3e-21 76.8 0.0 2.8e-21 75.7 0.0 1.6 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.19 CCF40317.1 - 5.4e-06 26.1 0.0 1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 PX domain zf-C2H2_4 PF13894.1 CCF40320.1 - 5.5e-06 26.3 13.4 0.027 14.7 1.0 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF40320.1 - 0.0005 20.2 13.7 0.096 13.0 1.6 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type APG6 PF04111.7 CCF40320.1 - 0.0053 15.8 1.1 0.0073 15.3 0.7 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 HALZ PF02183.13 CCF40320.1 - 0.0092 15.6 0.5 0.023 14.4 0.4 1.6 1 0 0 1 1 1 1 Homeobox associated leucine zipper Herpes_BLRF2 PF05812.7 CCF40320.1 - 0.01 15.6 0.4 0.022 14.5 0.3 1.5 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein HAP1_N PF04849.8 CCF40320.1 - 0.018 13.9 1.3 0.026 13.4 0.9 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region CCDC92 PF14916.1 CCF40320.1 - 0.02 14.4 0.2 0.036 13.6 0.2 1.4 1 0 0 1 1 1 0 Coiled-coil domain of unknown function Nic96 PF04097.9 CCF40320.1 - 0.023 12.8 0.1 0.029 12.5 0.0 1.1 1 0 0 1 1 1 0 Nup93/Nic96 DivIC PF04977.10 CCF40320.1 - 0.1 12.0 0.4 0.18 11.3 0.3 1.4 1 0 0 1 1 1 0 Septum formation initiator IncA PF04156.9 CCF40320.1 - 0.2 11.2 1.0 0.3 10.6 0.7 1.2 1 0 0 1 1 1 0 IncA protein Nup188 PF10487.4 CCF40321.1 - 5.9e-06 24.5 0.0 0.013 13.4 0.0 2.1 2 0 0 2 2 2 2 Nucleoporin subcomplex protein binding to Pom34 GATase PF00117.23 CCF40322.1 - 7.4e-50 169.0 0.0 9.2e-50 168.7 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 CCF40322.1 - 2.5e-05 23.8 0.2 0.00012 21.6 0.1 1.8 1 1 0 1 1 1 1 Peptidase C26 Sugar_tr PF00083.19 CCF40326.1 - 1e-55 189.1 2.1 1.3e-55 188.8 1.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF40326.1 - 3e-11 42.6 7.5 3.6e-11 42.3 5.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Mitofilin PF09731.4 CCF40328.1 - 5.3e-149 497.5 14.1 6.7e-149 497.2 9.8 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein Cas_DxTHG PF09455.5 CCF40328.1 - 0.053 12.6 2.0 0.13 11.3 1.4 1.5 2 0 0 2 2 2 0 CRISPR-associated (Cas) DxTHG family DUF1848 PF08902.6 CCF40328.1 - 0.22 11.0 1.8 0.34 10.3 0.7 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1848) DUF2683 PF10884.3 CCF40328.1 - 0.41 10.6 4.1 2.9 7.8 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2683) Tubulin PF00091.20 CCF40329.1 - 0.37 10.5 2.3 0.64 9.8 0.3 1.8 1 1 1 2 2 2 0 Tubulin/FtsZ family, GTPase domain DUF2435 PF10363.4 CCF40330.1 - 1.7e-14 53.4 1.3 9.9e-14 51.0 0.1 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2435) DUF2411 PF10304.4 CCF40330.1 - 2.1e-13 49.3 0.3 5.4e-13 48.0 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF2411) Adaptin_N PF01602.15 CCF40330.1 - 0.016 13.5 0.2 0.035 12.4 0.1 1.7 1 0 0 1 1 1 0 Adaptin N terminal region UNC45-central PF11701.3 CCF40330.1 - 0.082 12.5 0.1 2.8 7.5 0.0 2.8 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central Thr_synth_N PF14821.1 CCF40333.1 - 2.4e-28 97.9 0.0 5.8e-28 96.7 0.0 1.7 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.20 CCF40333.1 - 2.5e-18 66.3 0.0 1.7e-17 63.6 0.0 1.9 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DNA_methylase PF00145.12 CCF40335.1 - 3.1e-37 128.4 0.0 5.6e-37 127.6 0.0 1.4 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase BAH PF01426.13 CCF40335.1 - 8.2e-07 28.7 0.0 0.0075 16.0 0.0 2.7 2 1 0 2 2 2 2 BAH domain DNMT1-RFD PF12047.3 CCF40335.1 - 0.011 15.3 0.0 0.05 13.3 0.0 2.0 2 0 0 2 2 2 0 Cytosine specific DNA methyltransferase replication foci domain DUF155 PF02582.9 CCF40336.1 - 2.6e-40 138.1 0.0 3.5e-40 137.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Prosystemin PF07376.6 CCF40336.1 - 0.017 14.5 0.1 0.032 13.6 0.0 1.3 1 0 0 1 1 1 0 Prosystemin Zip PF02535.17 CCF40339.1 - 0.0025 16.9 1.0 0.004 16.2 0.7 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter Shisa PF13908.1 CCF40339.1 - 0.057 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF1510 PF07423.6 CCF40339.1 - 0.086 12.1 0.1 0.13 11.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF4106 PF13388.1 CCF40339.1 - 0.97 8.3 5.5 1.4 7.8 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Nexin_C PF08628.7 CCF40340.1 - 1.6e-30 105.4 0.1 6.7e-30 103.4 0.1 2.2 1 0 0 1 1 1 1 Sorting nexin C terminal PXA PF02194.10 CCF40340.1 - 4.8e-28 97.9 0.0 4.8e-28 97.9 0.0 2.5 3 0 0 3 3 3 1 PXA domain PX PF00787.19 CCF40340.1 - 1.8e-20 72.8 0.5 4.6e-20 71.4 0.4 1.7 1 0 0 1 1 1 1 PX domain RGS PF00615.14 CCF40340.1 - 4.9e-11 42.7 0.3 1.6e-10 41.1 0.0 2.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain Amidohydro_1 PF01979.15 CCF40341.1 - 7.1e-22 78.4 0.0 2.7e-21 76.5 0.0 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 CCF40341.1 - 6.4e-14 51.5 0.2 2.2e-13 49.7 0.1 2.0 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_4 PF13147.1 CCF40341.1 - 1.5e-11 44.8 0.1 7.8e-05 22.8 0.0 2.9 2 1 0 2 2 2 2 Amidohydrolase Amidohydro_3 PF07969.6 CCF40341.1 - 8.3e-06 25.2 2.4 4e-05 22.9 0.0 2.4 2 1 0 2 2 2 1 Amidohydrolase family Glyco_hydro_114 PF03537.8 CCF40341.1 - 0.046 13.5 0.0 0.14 11.9 0.0 1.8 1 0 0 1 1 1 0 Glycoside-hydrolase family GH114 DPM3 PF08285.6 CCF40341.1 - 0.19 11.5 0.0 0.39 10.5 0.0 1.4 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Cupin_2 PF07883.6 CCF40342.1 - 1.5e-10 40.3 0.5 2e-10 40.0 0.4 1.2 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.2 CCF40342.1 - 3.5e-05 23.4 0.9 4.3e-05 23.2 0.6 1.1 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.14 CCF40342.1 - 0.00024 20.8 0.4 0.00031 20.4 0.3 1.1 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_3 PF05899.7 CCF40342.1 - 0.00045 19.5 0.0 0.00074 18.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_1 PF00190.17 CCF40342.1 - 0.00069 19.0 0.0 0.00078 18.8 0.0 1.1 1 0 0 1 1 1 1 Cupin Cupin_7 PF12973.2 CCF40342.1 - 0.00083 19.1 0.0 0.0011 18.7 0.0 1.3 1 1 0 1 1 1 1 ChrR Cupin-like domain Pirin PF02678.11 CCF40342.1 - 0.04 13.8 0.4 0.047 13.5 0.3 1.2 1 0 0 1 1 1 0 Pirin DUF2917 PF11142.3 CCF40342.1 - 0.21 10.7 3.2 0.9 8.7 2.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2917) Zip PF02535.17 CCF40343.1 - 7.3e-29 100.7 29.3 1.3e-12 47.3 1.8 3.1 2 1 1 3 3 3 3 ZIP Zinc transporter HSP70 PF00012.15 CCF40346.1 - 6e-268 889.7 15.5 6.9e-268 889.5 10.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 CCF40346.1 - 1.5e-17 63.2 2.4 9.4e-17 60.5 0.4 2.1 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.13 CCF40346.1 - 0.0018 17.4 4.3 0.017 14.2 0.2 3.2 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase DDR PF08841.5 CCF40346.1 - 0.0034 16.2 0.5 0.066 12.0 0.1 2.3 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain FtsA PF14450.1 CCF40346.1 - 1 9.2 9.1 6.8 6.5 0.1 3.8 3 1 0 3 3 3 0 Cell division protein FtsA Pyr_redox_2 PF07992.9 CCF40347.1 - 1.3e-17 64.3 0.1 2.3e-16 60.3 0.0 3.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF40347.1 - 2.7e-10 40.4 2.0 1.7e-09 37.9 0.1 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF40347.1 - 1.8e-07 31.4 0.2 0.0011 19.0 0.1 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF40347.1 - 4.1e-05 22.6 0.1 0.00014 20.9 0.1 1.7 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.7 CCF40347.1 - 0.00026 20.0 0.1 0.0035 16.3 0.0 2.6 3 0 0 3 3 3 1 Lycopene cyclase protein HI0933_like PF03486.9 CCF40347.1 - 0.0026 16.2 5.9 0.17 10.2 0.0 3.2 3 1 1 4 4 4 2 HI0933-like protein Trp_halogenase PF04820.9 CCF40347.1 - 0.0059 15.2 0.5 4.5 5.7 0.0 3.1 2 1 1 3 3 3 2 Tryptophan halogenase DUF4147 PF13660.1 CCF40347.1 - 0.044 12.8 0.0 0.46 9.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4147) DAO PF01266.19 CCF40347.1 - 0.067 12.0 0.0 1.2 7.9 0.0 2.4 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.17 CCF40347.1 - 0.88 8.3 6.7 1.3 7.7 0.0 3.2 4 0 0 4 4 4 0 Glucose inhibited division protein A AAA_12 PF13087.1 CCF40348.1 - 1.7e-32 112.4 0.0 2.6e-32 111.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 CCF40348.1 - 1.8e-08 34.2 0.1 3.3e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 CCF40348.1 - 0.00067 19.2 0.0 0.41 10.1 0.0 2.2 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Methyltransf_23 PF13489.1 CCF40349.1 - 1.1e-21 77.2 0.1 1.8e-21 76.5 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF40349.1 - 2.2e-12 46.8 0.0 2.7e-11 43.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF40349.1 - 3.6e-12 46.8 0.0 3.7e-11 43.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF40349.1 - 6.5e-11 42.5 0.0 1.8e-10 41.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF40349.1 - 1.1e-08 35.4 0.0 1.2e-07 32.0 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF40349.1 - 5.3e-05 23.5 0.0 0.00016 21.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF40349.1 - 0.00033 19.7 0.0 0.003 16.6 0.0 2.3 2 1 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.13 CCF40349.1 - 0.00051 19.2 0.0 0.41 9.7 0.0 2.2 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family FtsJ PF01728.14 CCF40349.1 - 0.0012 18.9 0.1 0.0045 17.0 0.1 1.9 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_26 PF13659.1 CCF40349.1 - 0.0043 17.0 0.0 0.05 13.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 CCF40349.1 - 0.0087 15.2 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.4 CCF40349.1 - 0.018 14.4 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase MTS PF05175.9 CCF40349.1 - 0.021 14.2 0.0 0.042 13.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain DUF1311 PF07007.7 CCF40350.1 - 0.063 13.3 0.4 0.069 13.2 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1311) Vpu PF00558.14 CCF40350.1 - 0.15 11.6 0.3 0.16 11.5 0.2 1.1 1 0 0 1 1 1 0 Vpu protein bZIP_Maf PF03131.12 CCF40350.1 - 0.19 12.0 4.2 0.23 11.7 2.9 1.1 1 0 0 1 1 1 0 bZIP Maf transcription factor bZIP_1 PF00170.16 CCF40350.1 - 0.95 9.4 6.6 1.1 9.2 4.6 1.1 1 0 0 1 1 1 0 bZIP transcription factor RTA1 PF04479.8 CCF40351.1 - 2.1e-35 122.2 8.6 2.8e-35 121.8 5.9 1.1 1 0 0 1 1 1 1 RTA1 like protein Ninjurin PF04923.7 CCF40351.1 - 0.51 10.0 2.7 0.93 9.2 0.7 2.3 1 1 1 2 2 2 0 Ninjurin DUF2208 PF09973.4 CCF40351.1 - 2.1 7.4 6.7 4.3 6.5 0.2 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) Rieske PF00355.21 CCF40352.1 - 4.5e-09 35.7 0.0 9.8e-09 34.6 0.0 1.6 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 CCF40352.1 - 2.7e-05 23.8 0.0 4.5e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Phage_fiber_2 PF03406.8 CCF40352.1 - 1.4 8.6 4.3 0.52 9.9 1.0 1.7 2 0 0 2 2 2 0 Phage tail fibre repeat TFIIF_alpha PF05793.7 CCF40353.1 - 0.00067 18.1 15.6 0.001 17.5 10.8 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SPT6_acidic PF14632.1 CCF40354.1 - 4.7e-25 87.5 33.9 4.7e-25 87.5 23.5 3.0 2 1 1 3 3 3 1 Acidic N-terminal SPT6 AvrE PF11725.3 CCF40354.1 - 0.35 7.8 6.8 0.38 7.7 4.7 1.0 1 0 0 1 1 1 0 Pathogenicity factor Spore_coat_CotO PF14153.1 CCF40354.1 - 0.75 9.2 13.5 0.9 8.9 9.4 1.3 1 0 0 1 1 1 0 Spore coat protein CotO DDHD PF02862.12 CCF40354.1 - 3.7 7.2 8.1 5 6.8 5.6 1.2 1 0 0 1 1 1 0 DDHD domain Fumble PF03630.9 CCF40355.1 - 4.5e-130 433.4 0.0 4.1e-129 430.3 0.0 2.1 1 1 0 1 1 1 1 Fumble Chromo PF00385.19 CCF40356.1 - 0.00076 19.1 0.1 0.00098 18.7 0.1 1.2 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SRP40_C PF05022.7 CCF40357.1 - 1.7e-23 82.8 0.6 1.7e-23 82.8 0.4 2.2 2 0 0 2 2 2 1 SRP40, C-terminal domain EndoU_bacteria PF14436.1 CCF40357.1 - 0.011 15.5 1.5 0.022 14.5 0.3 2.0 2 0 0 2 2 2 0 Bacterial EndoU nuclease Utp14 PF04615.8 CCF40357.1 - 7.2 4.6 42.3 9.5 4.2 29.4 1.2 1 0 0 1 1 1 0 Utp14 protein A_deaminase PF00962.17 CCF40358.1 - 4.6e-40 137.5 0.0 5.8e-40 137.2 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase NUDIX PF00293.23 CCF40361.1 - 6.7e-08 32.2 0.0 8.7e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain VRR_NUC PF08774.6 CCF40363.1 - 8.8e-18 64.1 0.0 1.8e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 VRR-NUC domain Solute_trans_a PF03619.11 CCF40365.1 - 1.7e-79 267.0 19.7 2e-79 266.7 13.7 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Pyr_redox_3 PF13738.1 CCF40366.1 - 7.5e-13 49.0 0.0 2.3e-09 37.5 0.0 3.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF40366.1 - 1.5e-12 47.1 0.0 1.8e-07 30.3 0.0 2.3 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 CCF40366.1 - 0.00013 21.7 0.0 0.0058 16.4 0.0 2.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.19 CCF40366.1 - 0.00013 20.9 1.9 0.15 10.9 0.0 3.2 3 1 1 4 4 4 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF40366.1 - 0.00017 21.5 0.0 0.089 12.6 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 CCF40366.1 - 0.001 18.2 0.1 0.068 12.2 0.0 2.3 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.22 CCF40366.1 - 0.0058 17.0 0.2 16 6.0 0.0 3.7 4 0 0 4 4 4 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF40366.1 - 0.011 14.2 0.0 0.13 10.7 0.0 2.2 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.12 CCF40366.1 - 0.038 13.0 0.0 0.071 12.1 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.7 CCF40366.1 - 0.048 12.5 0.0 0.098 11.5 0.0 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_8 PF13450.1 CCF40366.1 - 0.081 12.9 0.2 0.43 10.6 0.0 2.3 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.15 CCF40366.1 - 0.098 12.7 0.0 16 5.5 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Peptidase_M20 PF01546.23 CCF40367.1 - 2.1e-24 86.0 0.0 3.1e-24 85.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 CCF40367.1 - 1.7e-13 50.3 0.0 4.3e-13 49.0 0.0 1.8 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 CCF40367.1 - 0.0093 15.7 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_S9 PF00326.16 CCF40368.1 - 3.8e-16 58.9 0.0 9.8e-16 57.6 0.0 1.7 2 1 1 3 3 3 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CCF40368.1 - 1.2e-09 38.0 0.1 1.7e-09 37.6 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 CCF40368.1 - 2.2e-07 30.6 0.1 1e-06 28.4 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.13 CCF40368.1 - 2.1e-05 23.8 0.0 4.8e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.2 CCF40368.1 - 0.00073 19.4 0.3 0.13 12.1 0.2 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF2424 PF10340.4 CCF40368.1 - 0.029 12.9 0.0 0.043 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2424) FSH1 PF03959.8 CCF40368.1 - 0.091 12.1 0.0 0.12 11.8 0.0 1.3 1 1 0 1 1 1 0 Serine hydrolase (FSH1) DUF2048 PF09752.4 CCF40368.1 - 0.11 11.4 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) Sugar_tr PF00083.19 CCF40369.1 - 1.4e-123 412.8 29.0 1.6e-123 412.6 20.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF40369.1 - 1.1e-19 70.3 57.6 6.2e-17 61.3 24.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.11 CCF40369.1 - 2.2e-06 26.6 0.1 0.0013 17.5 0.0 2.5 2 1 0 2 2 2 2 BT1 family Myb_DNA-binding PF00249.26 CCF40371.1 - 1.6e-19 69.6 4.3 1e-10 41.4 0.1 4.0 3 2 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CCF40371.1 - 6.1e-17 61.4 2.7 2.6e-08 33.8 0.1 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 CCF40371.1 - 0.00052 20.0 7.6 0.0018 18.3 0.2 3.6 3 0 0 3 3 3 1 Myb/SANT-like DNA-binding domain Methyltransf_23 PF13489.1 CCF40375.1 - 3e-12 46.5 0.0 3.5e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF40375.1 - 9.4e-06 25.2 0.0 0.0001 21.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF40375.1 - 0.0043 17.5 0.0 0.012 16.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF40375.1 - 0.013 15.9 0.1 0.13 12.7 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain Arabinose_bd PF12625.2 CCF40375.1 - 0.042 13.6 0.2 0.4 10.4 0.0 2.1 1 1 1 2 2 2 0 Arabinose-binding domain of AraC transcription regulator, N-term Methyltransf_18 PF12847.2 CCF40375.1 - 0.044 14.3 0.1 0.69 10.5 0.1 2.2 1 1 0 1 1 1 0 Methyltransferase domain BTB PF00651.26 CCF40376.1 - 1.3e-06 28.3 0.0 2.3e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain FKBP_C PF00254.23 CCF40377.1 - 1.8e-14 53.4 0.1 3.6e-14 52.5 0.0 1.5 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Cytomega_UL20A PF05984.7 CCF40377.1 - 0.003 17.7 0.0 0.0032 17.6 0.0 1.1 1 0 0 1 1 1 1 Cytomegalovirus UL20A protein 2OG-FeII_Oxy PF03171.15 CCF40378.1 - 8.7e-22 77.2 0.1 2.2e-21 75.9 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 CCF40378.1 - 2.6e-20 73.1 0.0 4.3e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal CorA PF01544.13 CCF40380.1 - 5.6e-13 48.5 0.0 1.3e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DivIVA PF05103.8 CCF40380.1 - 0.22 11.5 1.0 14 5.7 0.1 2.5 3 0 0 3 3 3 0 DivIVA protein Cep57_CLD_2 PF14197.1 CCF40380.1 - 1.7 8.6 4.7 0.71 9.8 0.3 2.2 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Filament PF00038.16 CCF40381.1 - 1.7e-06 27.7 165.2 0.006 16.0 23.1 6.7 1 1 5 6 6 6 6 Intermediate filament protein Reo_sigmaC PF04582.7 CCF40381.1 - 0.017 14.3 88.4 0.012 14.8 2.7 8.2 2 2 3 8 8 8 0 Reovirus sigma C capsid protein Herpes_BLLF1 PF05109.8 CCF40381.1 - 6.2 4.6 15.4 8.5 4.1 10.7 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) GSP_synth PF03738.9 CCF40382.1 - 2.6e-20 72.4 0.2 5e-20 71.5 0.1 1.5 1 0 0 1 1 1 1 Glutathionylspermidine synthase preATP-grasp SAC3_GANP PF03399.11 CCF40383.1 - 5.4e-25 88.1 0.0 7e-25 87.7 0.0 1.1 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 CCF40383.1 - 2.8e-22 79.0 0.0 4.6e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 Coatomer_WDAD PF04053.9 CCF40384.1 - 8.9e-149 496.0 0.0 2e-148 494.8 0.0 1.6 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.6 CCF40384.1 - 2.2e-85 286.7 0.0 2.9e-85 286.3 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.27 CCF40384.1 - 5e-50 165.6 9.5 2.4e-09 36.7 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.3 CCF40384.1 - 0.0071 14.5 7.6 0.35 8.9 0.0 3.8 2 1 2 4 4 4 2 Nucleoporin Nup120/160 Clathrin PF00637.15 CCF40384.1 - 0.03 13.9 0.2 0.23 11.0 0.0 2.3 2 0 0 2 2 2 0 Region in Clathrin and VPS Cyclin_N PF00134.18 CCF40386.1 - 0.00023 20.7 0.1 0.00067 19.2 0.0 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain ATG11 PF10377.4 CCF40387.1 - 2.4e-41 140.6 0.1 2.4e-41 140.6 0.1 3.2 3 1 0 3 3 3 1 Autophagy-related protein 11 ERM PF00769.14 CCF40387.1 - 6.2e-06 25.9 21.4 6.2e-06 25.9 14.8 5.3 2 1 3 5 5 5 1 Ezrin/radixin/moesin family Tropomyosin PF00261.15 CCF40387.1 - 0.00053 19.1 10.3 0.00053 19.1 7.1 5.0 1 1 1 3 3 3 1 Tropomyosin CENP-F_leu_zip PF10473.4 CCF40387.1 - 0.011 15.6 15.5 0.011 15.6 10.8 5.7 2 1 1 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3584 PF12128.3 CCF40387.1 - 0.045 11.1 70.8 1.1 6.4 36.8 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) EzrA PF06160.7 CCF40387.1 - 0.24 9.5 51.2 22 3.0 35.5 2.5 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Filament PF00038.16 CCF40387.1 - 4.4 6.6 71.8 0.019 14.4 28.8 3.1 2 1 1 3 3 3 0 Intermediate filament protein CALCOCO1 PF07888.6 CCF40387.1 - 7.3 4.7 58.8 3.9 5.6 20.6 2.9 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like adh_short PF00106.20 CCF40389.1 - 1.1e-12 48.2 0.2 2.1e-12 47.2 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 CCF40389.1 - 1.3e-05 24.9 0.1 2.2e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF40389.1 - 0.0053 16.7 0.0 0.0099 15.8 0.0 1.5 1 0 0 1 1 1 1 NADH(P)-binding adh_short_C2 PF13561.1 CCF40389.1 - 0.0057 16.4 0.0 0.0085 15.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Shikimate_DH PF01488.15 CCF40389.1 - 0.15 12.1 0.0 0.23 11.5 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase UFD1 PF03152.9 CCF40390.1 - 1.9e-67 225.7 0.0 2.5e-67 225.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 GYF PF02213.11 CCF40391.1 - 5.5e-11 41.8 1.1 1.1e-10 40.8 0.7 1.6 1 0 0 1 1 1 1 GYF domain HTH_WhiA PF02650.9 CCF40391.1 - 0.12 12.8 0.1 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 WhiA C-terminal HTH domain NACHT PF05729.7 CCF40392.1 - 9.2e-12 44.9 0.0 2.1e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Abhydrolase_6 PF12697.2 CCF40392.1 - 1.2e-08 35.1 0.2 2.4e-08 34.1 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family AAA_16 PF13191.1 CCF40392.1 - 5.2e-05 23.3 0.1 0.00023 21.2 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain DUF676 PF05057.9 CCF40392.1 - 0.00017 20.9 0.0 0.00032 20.0 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.2 CCF40392.1 - 0.00027 20.7 0.0 0.00082 19.1 0.0 1.8 2 0 0 2 2 1 1 Alpha/beta hydrolase family Cutinase PF01083.17 CCF40392.1 - 0.00051 19.8 0.0 0.00092 18.9 0.0 1.3 1 0 0 1 1 1 1 Cutinase AAA_22 PF13401.1 CCF40392.1 - 0.00066 19.8 0.0 0.0021 18.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain DUF726 PF05277.7 CCF40392.1 - 0.00096 18.1 0.0 0.0016 17.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) AAA PF00004.24 CCF40392.1 - 0.0026 17.9 0.0 0.022 14.9 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Lipase_3 PF01764.20 CCF40392.1 - 0.0076 15.8 0.0 0.017 14.7 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) RNA_helicase PF00910.17 CCF40392.1 - 0.012 15.8 0.0 0.041 14.0 0.0 1.9 2 0 0 2 2 2 0 RNA helicase PGAP1 PF07819.8 CCF40392.1 - 0.024 14.2 0.0 0.088 12.3 0.0 1.8 2 0 0 2 2 2 0 PGAP1-like protein AAA_17 PF13207.1 CCF40392.1 - 0.039 14.7 0.5 0.19 12.5 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.1 CCF40392.1 - 0.043 14.1 0.0 0.24 11.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.9 CCF40392.1 - 0.054 12.4 0.4 0.71 8.8 0.0 2.1 1 1 0 2 2 2 0 KAP family P-loop domain Ribosomal_L22 PF00237.14 CCF40392.1 - 0.062 13.2 0.0 0.29 11.0 0.0 2.1 2 1 1 3 3 3 0 Ribosomal protein L22p/L17e APS_kinase PF01583.15 CCF40392.1 - 0.13 11.8 0.1 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase Abhydrolase_3 PF07859.8 CCF40392.1 - 0.14 11.7 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold AAA_11 PF13086.1 CCF40392.1 - 0.14 11.6 0.0 0.36 10.3 0.0 1.7 2 1 0 2 2 2 0 AAA domain LCAT PF02450.10 CCF40392.1 - 0.17 10.7 0.0 0.31 9.9 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase HAD_2 PF13419.1 CCF40393.1 - 7.6e-23 81.6 0.0 1e-22 81.1 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CCF40393.1 - 1.6e-10 41.7 0.0 6.4e-10 39.8 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CCF40393.1 - 1.5e-09 37.4 0.0 8.6e-09 34.9 0.0 2.0 2 0 0 2 2 2 1 HAD-hyrolase-like NIF PF03031.13 CCF40393.1 - 0.013 15.1 0.0 1.5 8.4 0.0 2.5 1 1 0 2 2 2 0 NLI interacting factor-like phosphatase Prefoldin PF02996.12 CCF40393.1 - 0.042 13.5 0.1 0.066 12.8 0.1 1.3 1 0 0 1 1 1 0 Prefoldin subunit Hypoth_Ymh PF09509.5 CCF40393.1 - 0.14 11.8 0.0 0.34 10.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (Hypoth_ymh) SurE PF01975.12 CCF40395.1 - 1.2e-40 138.9 0.0 1.5e-40 138.6 0.0 1.1 1 0 0 1 1 1 1 Survival protein SurE Nucleoporin_FG PF13634.1 CCF40397.1 - 0.056 13.6 8.0 0.11 12.7 2.9 2.3 2 0 0 2 2 2 0 Nucleoporin FG repeat region Myb_DNA-bind_5 PF13873.1 CCF40397.1 - 0.09 12.6 0.1 0.21 11.5 0.1 1.5 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain PRA1 PF03208.14 CCF40398.1 - 9e-38 129.0 0.8 1.5e-37 128.3 0.6 1.3 1 0 0 1 1 1 1 PRA1 family protein CDC45 PF02724.9 CCF40398.1 - 4.5 5.1 22.6 0.37 8.7 12.4 1.5 2 0 0 2 2 2 0 CDC45-like protein Spt20 PF12090.3 CCF40399.1 - 0.028 13.7 5.3 0.065 12.5 0.6 2.6 2 0 0 2 2 2 0 Spt20 family PCI PF01399.22 CCF40400.1 - 6.2e-22 77.8 0.7 1.5e-21 76.6 0.3 1.8 2 0 0 2 2 2 1 PCI domain DDRGK PF09756.4 CCF40400.1 - 1.3e-05 24.6 0.8 2.2e-05 23.9 0.6 1.2 1 0 0 1 1 1 1 DDRGK domain TPR_8 PF13181.1 CCF40400.1 - 1.9e-05 24.0 0.1 1.2 9.1 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 CCF40400.1 - 0.0019 17.9 0.5 13 6.0 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 CCF40400.1 - 0.0023 17.6 0.9 0.064 13.0 0.2 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 CCF40400.1 - 0.003 17.0 0.1 0.94 9.1 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 CCF40400.1 - 0.0031 17.4 7.0 0.21 11.5 0.1 3.7 1 1 2 4 4 4 3 Tetratricopeptide repeat DUF4047 PF13256.1 CCF40400.1 - 0.0036 17.2 0.7 0.0074 16.2 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4047) PCI_Csn8 PF10075.4 CCF40400.1 - 0.0046 16.7 1.7 0.0079 15.9 1.2 1.4 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 DUF4456 PF14644.1 CCF40400.1 - 0.013 14.7 1.5 0.031 13.5 1.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4456) OmpH PF03938.9 CCF40400.1 - 0.052 13.4 1.5 0.072 13.0 1.1 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TPR_4 PF07721.9 CCF40400.1 - 0.099 13.1 0.1 0.57 10.7 0.0 2.4 2 0 0 2 2 1 0 Tetratricopeptide repeat TPR_16 PF13432.1 CCF40400.1 - 0.16 12.6 6.5 4.8 7.9 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 CCF40400.1 - 0.31 11.7 1.8 41 5.1 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat SIS PF01380.17 CCF40401.1 - 2.1e-09 37.0 0.0 3.5e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.1 CCF40401.1 - 0.064 12.9 0.1 0.48 10.1 0.1 2.1 1 1 1 2 2 2 0 SIS domain HECT PF00632.20 CCF40402.1 - 2.5e-91 306.1 0.0 3.4e-91 305.7 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.21 CCF40402.1 - 2.1e-33 113.7 21.9 1.8e-11 43.6 4.6 3.8 3 0 0 3 3 3 3 WW domain C2 PF00168.25 CCF40402.1 - 6.2e-16 58.0 0.2 1.6e-15 56.7 0.1 1.7 1 0 0 1 1 1 1 C2 domain DUF3292 PF11696.3 CCF40403.1 - 6.5e-180 599.1 0.1 8.6e-180 598.7 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3292) DUF4141 PF13605.1 CCF40403.1 - 0.06 12.5 0.1 0.14 11.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4141) Pectate_lyase PF03211.8 CCF40404.1 - 4.8e-75 251.6 6.6 5.8e-75 251.3 4.6 1.0 1 0 0 1 1 1 1 Pectate lyase Ribosomal_S8 PF00410.14 CCF40406.1 - 4.5e-24 84.7 0.0 6.4e-24 84.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 WD40 PF00400.27 CCF40407.1 - 1.9e-61 201.8 17.1 1.1e-10 40.9 0.3 8.4 8 0 0 8 8 8 7 WD domain, G-beta repeat Nup160 PF11715.3 CCF40407.1 - 1.9e-14 52.7 0.5 0.005 15.0 0.0 4.2 1 1 1 4 4 4 4 Nucleoporin Nup120/160 F-box-like PF12937.2 CCF40407.1 - 2.1e-13 49.7 0.1 4.4e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF40407.1 - 5.7e-10 38.5 0.0 1.4e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 F-box domain BBS2_Mid PF14783.1 CCF40407.1 - 0.0093 15.7 0.0 1.3 8.8 0.0 3.6 2 1 3 5 5 5 1 Ciliary BBSome complex subunit 2, middle region PPV_E2_C PF00511.12 CCF40410.1 - 0.078 12.9 0.0 0.1 12.5 0.0 1.1 1 0 0 1 1 1 0 E2 (early) protein, C terminal DUF3441 PF11923.3 CCF40411.1 - 5e-36 122.7 0.1 5e-36 122.7 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3441) FbpA PF05833.6 CCF40411.1 - 2.7e-31 108.6 19.0 2.7e-31 108.6 13.1 2.5 2 1 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) DUF814 PF05670.8 CCF40411.1 - 5.1e-24 83.9 0.0 1.2e-23 82.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF814) TFIIF_alpha PF05793.7 CCF40411.1 - 8.7e-05 21.0 3.6 8.7e-05 21.0 2.5 2.3 2 0 0 2 2 2 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) eIF-3_zeta PF05091.7 CCF40412.1 - 0.57 8.7 12.6 0.96 7.9 8.7 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Macoilin PF09726.4 CCF40412.1 - 1.4 7.1 27.8 0.22 9.7 10.6 2.3 2 0 0 2 2 2 0 Transmembrane protein DUF4175 PF13779.1 CCF40412.1 - 3.4 5.2 27.1 5.6 4.5 18.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Folate_carrier PF01770.13 CCF40412.1 - 3.8 5.9 3.5 6.3 5.1 2.4 1.2 1 0 0 1 1 1 0 Reduced folate carrier Nucleo_P87 PF07267.6 CCF40412.1 - 5.2 5.6 10.2 8.1 4.9 7.1 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Serinc PF03348.10 CCF40412.1 - 6.1 5.4 5.1 9.5 4.8 3.5 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Zip PF02535.17 CCF40412.1 - 6.1 5.7 9.6 12 4.7 6.7 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter Globin PF00042.17 CCF40415.1 - 1.6e-09 38.1 0.0 2.5e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Globin FAD_binding_6 PF00970.19 CCF40415.1 - 2.3e-07 30.8 0.0 3.9e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 CCF40415.1 - 1.1e-05 25.9 0.0 2.1e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Protoglobin PF11563.3 CCF40415.1 - 0.00043 19.9 0.1 0.00064 19.4 0.1 1.3 1 0 0 1 1 1 1 Protoglobin NAD_binding_6 PF08030.7 CCF40415.1 - 0.0063 16.4 0.0 0.017 15.0 0.0 1.7 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Fer4_2 PF12797.2 CCF40416.1 - 0.42 10.6 3.5 0.75 9.8 0.3 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain p450 PF00067.17 CCF40417.1 - 1.9e-54 184.9 0.0 2e-54 184.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_3 PF01494.14 CCF40420.1 - 7.7e-19 67.9 0.0 6.8e-11 41.8 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 CCF40420.1 - 1.6e-12 47.0 2.1 1.3e-06 27.5 0.1 2.3 1 1 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.9 CCF40420.1 - 9.5e-05 21.0 0.4 0.0098 14.4 0.1 2.1 2 0 0 2 2 2 2 HI0933-like protein Lycopene_cycl PF05834.7 CCF40420.1 - 0.00012 21.1 0.8 0.00084 18.3 0.6 1.9 1 1 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.9 CCF40420.1 - 0.00013 21.9 0.0 0.00067 19.5 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF40420.1 - 0.0005 19.0 2.6 0.0019 17.1 0.4 2.1 1 1 1 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.1 CCF40420.1 - 0.00051 20.1 0.0 0.00088 19.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF40420.1 - 0.0017 18.2 0.0 0.0048 16.8 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 CCF40420.1 - 0.0024 17.0 0.3 0.038 13.0 0.0 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.22 CCF40420.1 - 0.0033 17.7 0.1 0.89 10.0 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF40420.1 - 0.069 11.7 0.0 0.12 10.9 0.0 1.4 2 0 0 2 2 2 0 Tryptophan halogenase RNA_pol_Rpc4 PF05132.9 CCF40421.1 - 3e-13 49.8 0.2 3.5e-13 49.6 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase III RPC4 DUF4380 PF14315.1 CCF40421.1 - 0.08 12.1 0.0 0.086 12.0 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4380) Glyco_hydro_63 PF03200.11 CCF40423.1 - 4.2e-07 28.2 5.6 5.8e-06 24.4 0.1 3.5 3 1 0 3 3 3 2 Mannosyl oligosaccharide glucosidase MFS_1 PF07690.11 CCF40424.1 - 6.5e-29 100.7 21.3 8e-29 100.4 14.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Cellulase PF00150.13 CCF40426.1 - 6.3e-50 169.9 4.3 8.8e-50 169.4 2.9 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.13 CCF40426.1 - 4.5e-11 42.1 10.5 4.5e-11 42.1 7.3 2.3 2 0 0 2 2 2 1 Fungal cellulose binding domain SSP160 PF06933.6 CCF40426.1 - 0.41 8.5 13.2 0.052 11.5 5.9 1.8 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 FAD_binding_7 PF03441.9 CCF40427.1 - 1.4e-75 254.0 0.1 1.6e-75 253.8 0.1 1.0 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DUF4045 PF13254.1 CCF40428.1 - 1.8e-81 274.6 41.9 3e-49 168.4 18.9 6.5 4 2 3 7 7 7 2 Domain of unknown function (DUF4045) Gelsolin PF00626.17 CCF40428.1 - 0.0048 16.5 0.1 0.046 13.4 0.0 2.5 2 0 0 2 2 2 1 Gelsolin repeat Arf PF00025.16 CCF40430.1 - 3.3e-62 208.7 0.3 3.7e-62 208.6 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 CCF40430.1 - 4.3e-09 35.5 0.6 0.0015 17.2 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.17 CCF40430.1 - 9.2e-09 34.8 0.0 1.1e-08 34.6 0.0 1.0 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.18 CCF40430.1 - 1.2e-07 31.6 0.0 2.1e-07 30.8 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 CCF40430.1 - 2.1e-06 27.0 0.0 2.6e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 CCF40430.1 - 2.4e-06 28.0 0.0 3.5e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein SRPRB PF09439.5 CCF40430.1 - 9.1e-06 25.0 0.0 1.2e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 CCF40430.1 - 8.3e-05 22.0 0.0 0.0084 15.5 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 CCF40430.1 - 0.014 16.2 0.1 0.018 15.8 0.0 1.4 1 1 0 1 1 1 0 AAA domain NACHT PF05729.7 CCF40430.1 - 0.024 14.3 0.3 0.29 10.7 0.0 2.0 2 0 0 2 2 2 0 NACHT domain PduV-EutP PF10662.4 CCF40430.1 - 0.027 13.9 0.0 0.056 12.9 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.18 CCF40430.1 - 0.034 13.9 0.0 0.48 10.2 0.0 2.0 2 0 0 2 2 2 0 Dynamin family 6PF2K PF01591.13 CCF40430.1 - 0.12 11.4 0.1 0.32 10.0 0.0 1.6 2 0 0 2 2 2 0 6-phosphofructo-2-kinase Acetyltransf_7 PF13508.1 CCF40431.1 - 0.0074 16.4 0.0 0.023 14.8 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CCF40431.1 - 0.14 12.1 0.0 0.36 10.9 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Ecl1 PF12855.2 CCF40433.1 - 1.9e-07 30.2 0.5 1.9e-07 30.2 0.3 1.9 3 0 0 3 3 3 1 Life-span regulatory factor SLD3 PF08639.5 CCF40433.1 - 0.0063 15.1 4.0 0.0062 15.2 2.8 1.0 1 0 0 1 1 1 1 DNA replication regulator SLD3 zf-MYND PF01753.13 CCF40433.1 - 0.033 14.0 1.9 0.061 13.2 1.3 1.4 1 0 0 1 1 1 0 MYND finger Ank_2 PF12796.2 CCF40435.1 - 5.4e-85 279.8 15.4 1.3e-15 57.5 0.1 7.2 3 1 5 8 8 8 8 Ankyrin repeats (3 copies) Ank PF00023.25 CCF40435.1 - 2e-59 194.5 24.0 3e-06 26.7 0.2 14.5 15 0 0 15 15 15 12 Ankyrin repeat Ank_4 PF13637.1 CCF40435.1 - 1.6e-48 162.2 7.3 2.1e-07 31.2 0.0 10.3 4 2 5 10 10 10 10 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF40435.1 - 1.8e-45 148.3 15.9 0.001 19.1 0.0 13.9 14 0 0 14 14 14 11 Ankyrin repeat Ank_5 PF13857.1 CCF40435.1 - 3e-39 132.1 18.6 7.7e-08 32.3 0.0 9.6 3 1 8 11 11 11 10 Ankyrin repeats (many copies) TPR_12 PF13424.1 CCF40436.1 - 2.9e-06 27.1 0.1 6.7e-06 25.9 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 CCF40436.1 - 2.6e-05 23.7 0.1 0.0072 16.1 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 CCF40436.1 - 5.3e-05 22.7 0.1 0.024 14.3 0.0 3.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 CCF40436.1 - 9.2e-05 22.0 0.5 0.0059 16.2 0.1 2.2 1 1 1 2 2 2 2 TPR repeat TPR_19 PF14559.1 CCF40436.1 - 0.00042 20.5 0.9 0.0011 19.3 0.2 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 CCF40436.1 - 0.00055 19.4 0.2 0.058 13.0 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 CCF40436.1 - 0.015 15.8 5.4 0.59 10.9 0.1 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 CCF40436.1 - 0.029 15.0 4.0 0.059 14.0 0.5 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat TRP PF06011.7 CCF40437.1 - 5.5e-46 157.0 15.2 5.5e-46 157.0 10.5 2.2 1 1 1 2 2 2 1 Transient receptor potential (TRP) ion channel Cellulase PF00150.13 CCF40438.1 - 3.5e-10 39.5 2.3 3.5e-10 39.5 1.6 1.5 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) EphA2_TM PF14575.1 CCF40438.1 - 0.0029 17.9 0.0 0.01 16.2 0.0 1.9 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain DUF3357 PF11837.3 CCF40438.1 - 0.0071 16.1 0.0 0.037 13.8 0.0 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3357) Adipogenin PF15202.1 CCF40438.1 - 0.02 14.7 0.1 0.042 13.7 0.1 1.4 1 0 0 1 1 1 0 Adipogenin Ninjurin PF04923.7 CCF40438.1 - 0.046 13.4 0.0 0.081 12.6 0.0 1.3 1 0 0 1 1 1 0 Ninjurin Radical_SAM PF04055.16 CCF40438.1 - 0.048 13.8 0.0 0.23 11.6 0.0 2.1 2 0 0 2 2 2 0 Radical SAM superfamily DUF1510 PF07423.6 CCF40438.1 - 0.1 11.9 0.1 0.1 11.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) PLRV_ORF5 PF01690.12 CCF40438.1 - 0.32 10.1 9.3 0.45 9.6 6.5 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein TMEM154 PF15102.1 CCF40438.1 - 0.64 9.7 1.8 1.1 9.0 0.0 2.0 2 0 0 2 2 2 0 TMEM154 protein family FAM176 PF14851.1 CCF40438.1 - 3.1 7.4 0.0 3.1 7.4 0.0 2.8 2 1 1 3 3 3 0 FAM176 family Transket_pyr PF02779.19 CCF40439.1 - 6.7e-20 71.3 0.1 9.3e-20 70.8 0.1 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain MCR_gamma PF02240.11 CCF40439.1 - 0.00076 18.6 0.5 0.0016 17.6 0.2 1.6 2 0 0 2 2 2 1 Methyl-coenzyme M reductase gamma subunit MFS_1 PF07690.11 CCF40440.1 - 2.5e-28 98.8 11.6 3e-28 98.5 8.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily EXS PF03124.9 CCF40440.1 - 0.14 11.1 2.7 0.3 10.0 1.9 1.6 1 1 0 1 1 1 0 EXS family DUF3125 PF11323.3 CCF40441.1 - 0.12 12.1 0.3 0.2 11.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3125) Peptidase_M22 PF00814.20 CCF40442.1 - 0.018 14.5 0.3 0.027 13.9 0.2 1.2 1 0 0 1 1 1 0 Glycoprotease family ABC_membrane PF00664.18 CCF40443.1 - 4.6e-76 255.8 34.3 1.7e-46 158.8 11.4 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 CCF40443.1 - 3.5e-66 221.6 0.0 1.3e-31 109.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 CCF40443.1 - 3.9e-13 49.1 0.0 4.5e-05 22.7 0.0 3.3 1 1 2 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF40443.1 - 2.1e-10 41.0 0.0 0.12 12.3 0.1 5.0 4 1 0 4 4 4 2 AAA domain AAA_16 PF13191.1 CCF40443.1 - 2.5e-09 37.3 1.0 0.00065 19.7 0.0 3.4 4 0 0 4 4 3 2 AAA ATPase domain AAA_29 PF13555.1 CCF40443.1 - 2.9e-09 36.2 0.3 0.00034 20.0 0.2 3.3 3 0 0 3 3 3 2 P-loop containing region of AAA domain DUF258 PF03193.11 CCF40443.1 - 1.2e-07 31.0 0.0 0.068 12.3 0.0 3.4 3 0 0 3 3 3 2 Protein of unknown function, DUF258 ABC_ATPase PF09818.4 CCF40443.1 - 3e-07 29.4 1.4 0.023 13.3 0.1 3.3 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_17 PF13207.1 CCF40443.1 - 7.3e-07 30.0 0.1 0.069 13.9 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_25 PF13481.1 CCF40443.1 - 0.00015 21.2 6.6 0.1 12.0 0.0 3.9 5 0 0 5 5 4 2 AAA domain SbcCD_C PF13558.1 CCF40443.1 - 0.00043 20.1 1.6 0.9 9.4 0.1 3.5 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.1 CCF40443.1 - 0.00069 19.7 2.3 1.2 9.3 0.1 3.5 2 2 0 2 2 2 2 AAA domain AAA_14 PF13173.1 CCF40443.1 - 0.0011 18.8 0.2 1.9 8.3 0.0 3.8 3 2 1 5 5 4 1 AAA domain AAA_33 PF13671.1 CCF40443.1 - 0.0018 18.1 0.0 2.6 7.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain APS_kinase PF01583.15 CCF40443.1 - 0.0018 17.9 0.0 2.5 7.7 0.0 3.9 3 1 1 4 4 4 1 Adenylylsulphate kinase AAA_23 PF13476.1 CCF40443.1 - 0.0026 18.1 0.6 0.48 10.7 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.1 CCF40443.1 - 0.0029 17.8 0.0 3.4 7.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 CCF40443.1 - 0.0036 17.0 0.1 6.1 6.5 0.0 3.4 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 CCF40443.1 - 0.0037 17.2 0.6 0.59 10.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.15 CCF40443.1 - 0.008 14.9 0.0 3.5 6.2 0.0 2.5 2 0 0 2 2 2 2 G-protein alpha subunit DUF87 PF01935.12 CCF40443.1 - 0.014 15.2 2.2 3.6 7.3 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function DUF87 AAA_10 PF12846.2 CCF40443.1 - 0.017 14.5 3.8 12 5.1 0.3 4.2 5 0 0 5 5 5 0 AAA-like domain ATP-synt_ab PF00006.20 CCF40443.1 - 0.022 14.2 0.5 23 4.4 0.0 3.4 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain Zeta_toxin PF06414.7 CCF40443.1 - 0.026 13.6 0.0 1.6 7.7 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin MobB PF03205.9 CCF40443.1 - 0.046 13.4 0.1 12 5.5 0.0 3.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 CCF40443.1 - 0.048 13.6 0.1 6.3 6.7 0.1 3.0 2 1 0 2 2 2 0 50S ribosome-binding GTPase RNA_helicase PF00910.17 CCF40443.1 - 0.093 12.9 0.0 11 6.2 0.0 3.0 2 0 0 2 2 2 0 RNA helicase WD40 PF00400.27 CCF40444.1 - 3.9e-28 96.2 2.4 3e-14 52.2 0.0 2.8 4 0 0 4 4 4 2 WD domain, G-beta repeat Nup160 PF11715.3 CCF40444.1 - 7.9e-05 20.9 0.1 0.00011 20.4 0.1 1.3 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Gmad1 PF10647.4 CCF40444.1 - 0.032 13.6 0.7 0.043 13.2 0.5 1.2 1 0 0 1 1 1 0 Lipoprotein LpqB beta-propeller domain DUF3646 PF12362.3 CCF40444.1 - 0.11 12.4 0.2 3.3 7.6 0.0 2.1 2 0 0 2 2 2 0 DNA polymerase III gamma and tau subunits C terminal Aldedh PF00171.17 CCF40445.1 - 1.5e-121 406.0 0.0 2.6e-121 405.2 0.0 1.3 1 1 0 1 1 1 1 Aldehyde dehydrogenase family BRO1 PF03097.13 CCF40446.1 - 5.3e-10 38.5 0.0 7.8e-10 38.0 0.0 1.2 1 0 0 1 1 1 1 BRO1-like domain Alg6_Alg8 PF03155.10 CCF40447.1 - 3.1e-128 428.5 23.7 5.1e-80 269.5 7.3 2.0 2 0 0 2 2 2 2 ALG6, ALG8 glycosyltransferase family Utp12 PF04003.7 CCF40448.1 - 4.5e-22 78.0 0.1 6.6e-22 77.5 0.1 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40 PF00400.27 CCF40448.1 - 0.00054 19.7 0.0 0.00092 19.0 0.0 1.4 1 0 0 1 1 1 1 WD domain, G-beta repeat UTP15_C PF09384.5 CCF40448.1 - 0.017 14.8 0.0 0.032 13.9 0.0 1.4 1 0 0 1 1 1 0 UTP15 C terminal Pkinase PF00069.20 CCF40449.1 - 3e-15 56.0 0.1 4.3e-15 55.5 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF40449.1 - 1.4e-10 40.6 0.0 1.7e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF40449.1 - 6.3e-06 25.3 0.0 1e-05 24.6 0.0 1.3 1 1 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 CCF40449.1 - 0.019 13.8 0.1 0.028 13.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Choline_kinase PF01633.15 CCF40449.1 - 0.086 12.3 0.1 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.9 CCF40449.1 - 0.15 11.0 0.2 0.19 10.7 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF446 PF04287.7 CCF40450.1 - 0.12 12.2 0.4 0.24 11.2 0.2 1.5 1 1 1 2 2 2 0 tRNA pseudouridine synthase C SnoaL_4 PF13577.1 CCF40451.1 - 3e-13 49.7 0.5 4e-13 49.3 0.3 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.1 CCF40451.1 - 0.0027 17.8 1.8 0.004 17.3 1.2 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4440) DUF3636 PF12331.3 CCF40452.1 - 4e-28 97.8 0.1 9.5e-28 96.6 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3636) TMF_TATA_bd PF12325.3 CCF40452.1 - 0.94 9.2 5.9 1.7 8.3 4.1 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Methyltransf_2 PF00891.13 CCF40455.1 - 2.8e-41 141.2 0.1 3.9e-41 140.8 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase FAD_binding_3 PF01494.14 CCF40455.1 - 1.7e-08 33.9 0.0 0.0014 17.7 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Methyltransf_18 PF12847.2 CCF40455.1 - 6.9e-05 23.3 0.0 0.00015 22.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain NAD_binding_8 PF13450.1 CCF40455.1 - 0.00075 19.4 0.0 0.002 18.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Methyltransf_23 PF13489.1 CCF40455.1 - 0.005 16.5 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain GAF PF01590.21 CCF40458.1 - 0.00043 20.4 0.1 0.00055 20.0 0.1 1.1 1 0 0 1 1 1 1 GAF domain GAF_2 PF13185.1 CCF40458.1 - 0.05 14.0 0.0 0.41 11.1 0.0 1.9 1 1 0 1 1 1 0 GAF domain Spermine_synth PF01564.12 CCF40459.1 - 5e-97 323.6 0.1 6.3e-97 323.3 0.1 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_31 PF13847.1 CCF40459.1 - 0.0002 20.9 0.0 0.0003 20.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF40459.1 - 0.00067 19.6 0.0 0.0013 18.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF40459.1 - 0.0021 17.8 0.0 0.022 14.4 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain DUF43 PF01861.11 CCF40459.1 - 0.0026 16.7 0.0 0.0042 16.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function DUF43 Methyltransf_18 PF12847.2 CCF40459.1 - 0.0044 17.5 0.0 0.0085 16.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF40459.1 - 0.011 16.2 0.3 0.063 13.7 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Ank_2 PF12796.2 CCF40461.1 - 8e-33 112.6 0.1 3.7e-18 65.6 0.1 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 CCF40461.1 - 2.4e-22 77.5 0.2 7.2e-10 38.1 0.0 3.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 CCF40461.1 - 1.2e-21 76.2 1.5 2.9e-12 46.3 0.1 2.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 CCF40461.1 - 2.5e-20 72.4 0.0 1.3e-13 51.0 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF40461.1 - 1.7e-19 67.9 0.1 1.3e-06 28.0 0.0 3.9 4 0 0 4 4 4 3 Ankyrin repeat Nitro_FeMo-Co PF02579.12 CCF40461.1 - 0.078 13.0 0.1 0.31 11.1 0.1 1.9 1 1 1 2 2 2 0 Dinitrogenase iron-molybdenum cofactor Pkinase PF00069.20 CCF40463.1 - 6.2e-71 238.5 0.0 8.7e-71 238.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF40463.1 - 1.3e-33 116.2 0.0 1.7e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 CCF40463.1 - 1.4e-11 44.7 2.0 4.1e-11 43.2 1.4 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 CCF40463.1 - 0.00074 18.5 0.0 0.0015 17.5 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 CCF40463.1 - 0.067 12.2 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_S10 PF00450.17 CCF40464.1 - 1.4e-90 304.5 0.0 1.7e-90 304.2 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 CCF40464.1 - 7.3e-05 22.7 0.3 0.0052 16.6 0.2 2.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family RRM_1 PF00076.17 CCF40465.1 - 4.9e-39 131.8 0.0 1.4e-18 66.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF40465.1 - 1e-26 92.7 0.0 7.2e-13 48.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF40465.1 - 4.1e-11 42.5 0.0 0.00023 20.9 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4140 PF13600.1 CCF40465.1 - 0.045 14.1 0.0 0.045 14.1 0.0 3.7 4 1 0 4 4 4 0 N-terminal domain of unknown function (DUF4140) NDUFB10 PF10249.4 CCF40466.1 - 0.0014 18.7 0.0 0.002 18.2 0.0 1.2 1 1 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 HWE_HK PF07536.9 CCF40466.1 - 0.089 13.2 0.0 0.13 12.7 0.0 1.2 1 0 0 1 1 1 0 HWE histidine kinase Ribosomal_L37 PF08561.5 CCF40467.1 - 2e-30 104.1 5.4 8.1e-24 83.0 0.1 2.2 1 1 1 2 2 2 2 Mitochondrial ribosomal protein L37 TAFII55_N PF04658.8 CCF40468.1 - 7.6e-47 158.8 0.0 7.6e-47 158.8 0.0 2.0 3 0 0 3 3 3 1 TAFII55 protein conserved region FlxA PF14282.1 CCF40468.1 - 1 9.3 13.1 0.22 11.4 5.7 2.5 2 1 0 2 2 2 0 FlxA-like protein GPI-anchored PF10342.4 CCF40469.1 - 4.6e-08 33.4 0.1 4.6e-08 33.4 0.1 2.2 3 0 0 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SWI-SNF_Ssr4 PF08549.5 CCF40470.1 - 9.2e-140 467.0 14.0 1.4e-139 466.4 9.7 1.2 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1750) zf-C2H2_4 PF13894.1 CCF40471.1 - 2e-05 24.5 7.8 0.19 12.1 0.1 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CCF40471.1 - 0.00072 19.7 8.7 0.024 14.9 0.2 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.3 CCF40471.1 - 0.0017 18.4 2.0 0.076 13.1 0.1 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 CCF40471.1 - 0.0067 16.7 12.2 0.17 12.3 0.3 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type Transaldolase PF00923.14 CCF40472.1 - 9.7e-40 136.4 0.0 1.1e-39 136.2 0.0 1.1 1 0 0 1 1 1 1 Transaldolase DUF4279 PF14106.1 CCF40472.1 - 0.012 15.5 0.0 3.2 7.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4279) Transp_cyt_pur PF02133.10 CCF40473.1 - 3.7e-80 269.6 34.0 4.2e-80 269.4 23.5 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin SSF PF00474.12 CCF40474.1 - 3.2e-23 82.0 24.6 4.4e-23 81.5 17.1 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family Nop14 PF04147.7 CCF40475.1 - 5.8 4.7 22.5 10 3.8 15.6 1.3 1 0 0 1 1 1 0 Nop14-like family Lactamase_B PF00753.22 CCF40476.1 - 4.4e-23 81.9 1.2 5.5e-23 81.6 0.8 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CCF40476.1 - 4e-06 26.4 0.1 5.2e-06 26.1 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 CCF40476.1 - 0.021 14.5 0.1 0.03 14.0 0.1 1.3 1 1 0 1 1 1 0 Beta-lactamase superfamily domain EthD PF07110.6 CCF40477.1 - 2.1e-06 28.5 0.1 4.2e-06 27.6 0.1 1.5 1 1 0 1 1 1 1 EthD domain Shisa PF13908.1 CCF40478.1 - 4.4 7.4 12.5 0.14 12.3 4.7 1.5 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator Fungal_trans_2 PF11951.3 CCF40479.1 - 2.7e-09 36.1 0.0 3.5e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF40480.1 - 1.5e-07 31.2 10.2 2.6e-07 30.4 7.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Synaptobrevin PF00957.16 CCF40482.1 - 2.9e-14 52.4 0.6 4.2e-14 51.9 0.4 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.1 CCF40482.1 - 3.3e-14 52.2 0.0 6.9e-14 51.1 0.0 1.5 1 1 0 1 1 1 1 Regulated-SNARE-like domain Imm43 PF15602.1 CCF40482.1 - 0.064 13.2 0.0 0.37 10.7 0.0 1.9 2 0 0 2 2 2 0 Immunity protein 43 TcdB_N PF12918.2 CCF40482.1 - 0.12 12.5 0.4 0.49 10.5 0.4 1.9 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain Tbf5 PF06331.7 CCF40482.1 - 0.13 12.0 0.5 0.23 11.2 0.3 1.3 1 0 0 1 1 1 0 Transcription factor TFIIH complex subunit Tfb5 Cnd2 PF05786.9 CCF40483.1 - 1.1e-205 685.3 6.1 1.4e-205 685.0 4.2 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 TraH_2 PF06871.6 CCF40483.1 - 0.14 11.6 4.3 0.3 10.5 3.0 1.5 1 0 0 1 1 1 0 TraH_2 GET2 PF08690.5 CCF40483.1 - 2.8 7.1 8.0 0.21 10.7 1.1 2.1 2 0 0 2 2 2 0 GET complex subunit GET2 FAM176 PF14851.1 CCF40483.1 - 5.6 6.6 8.2 7 6.3 0.7 2.5 2 0 0 2 2 2 0 FAM176 family DUF1751 PF08551.5 CCF40484.1 - 0.012 15.8 0.3 0.023 15.0 0.1 1.6 1 1 0 1 1 1 0 Eukaryotic integral membrane protein (DUF1751) DER1 PF04511.10 CCF40484.1 - 0.022 14.2 1.4 0.027 13.9 0.9 1.1 1 0 0 1 1 1 0 Der1-like family Prenyltransf PF01255.14 CCF40485.1 - 2.2e-87 291.8 0.0 3.4e-87 291.2 0.0 1.2 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase PHD PF00628.24 CCF40486.1 - 1.7e-09 37.1 8.0 2.8e-09 36.4 5.5 1.4 1 0 0 1 1 1 1 PHD-finger ING PF12998.2 CCF40486.1 - 1.1e-06 28.8 0.0 0.0041 17.3 0.0 2.6 2 0 0 2 2 2 2 Inhibitor of growth proteins N-terminal histone-binding zf-HC5HC2H PF13771.1 CCF40486.1 - 0.13 12.4 3.2 0.27 11.4 2.2 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain LRR_6 PF13516.1 CCF40488.1 - 0.007 16.3 0.0 0.89 9.8 0.0 3.8 4 0 0 4 4 4 1 Leucine Rich repeat LRR_4 PF12799.2 CCF40488.1 - 0.011 15.3 0.9 0.95 9.1 0.0 3.2 2 1 3 5 5 5 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CCF40488.1 - 0.04 13.6 4.2 5.2 6.9 0.1 3.9 4 0 0 4 4 4 0 Leucine rich repeat Pectate_lyase_3 PF12708.2 CCF40489.1 - 1.8e-20 74.0 0.5 2.2e-20 73.7 0.3 1.1 1 0 0 1 1 1 1 Pectate lyase superfamily protein End_N_terminal PF12218.3 CCF40489.1 - 0.024 14.1 0.3 0.043 13.2 0.2 1.5 1 0 0 1 1 1 0 N terminal extension of bacteriophage endosialidase DUF3405 PF11885.3 CCF40492.1 - 9.7e-176 584.8 0.0 9.7e-176 584.8 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3405) Asp-B-Hydro_N PF05279.6 CCF40492.1 - 0.19 11.5 20.5 0.3 10.8 14.2 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region APG6 PF04111.7 CCF40492.1 - 0.31 10.0 21.8 0.49 9.4 15.1 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 HSP70 PF00012.15 CCF40492.1 - 0.43 8.4 12.7 0.62 7.9 8.8 1.1 1 0 0 1 1 1 0 Hsp70 protein Herpes_UL25 PF01499.11 CCF40492.1 - 0.74 8.0 11.6 1.2 7.4 8.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL25 family OmpH PF03938.9 CCF40492.1 - 1.6 8.6 18.5 2.5 7.9 12.8 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.1 CCF40492.1 - 4 6.2 12.3 6.1 5.7 8.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) IncA PF04156.9 CCF40492.1 - 4.3 6.8 14.4 6.7 6.2 10.0 1.2 1 0 0 1 1 1 0 IncA protein Lyase_aromatic PF00221.14 CCF40494.1 - 0.054 11.9 0.0 0.062 11.7 0.0 1.1 1 0 0 1 1 1 0 Aromatic amino acid lyase APG12 PF04110.8 CCF40495.1 - 1e-28 99.3 0.0 1.3e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.11 CCF40495.1 - 3.4e-07 30.1 0.0 4.1e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Pantoate_transf PF02548.10 CCF40496.1 - 4.5e-103 343.9 0.1 5.3e-103 343.6 0.1 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.1 CCF40496.1 - 2e-09 37.0 1.1 5e-09 35.7 0.7 1.7 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase TRI12 PF06609.8 CCF40497.1 - 1.8e-08 33.0 3.4 2e-08 32.9 2.3 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.11 CCF40497.1 - 2.1e-06 26.7 20.1 2.7e-06 26.3 13.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MNSV_P7B PF06692.6 CCF40497.1 - 0.13 12.0 0.3 0.31 10.8 0.2 1.6 1 0 0 1 1 1 0 Melon necrotic spot virus P7B protein MFS_1 PF07690.11 CCF40498.1 - 4.5e-11 42.0 14.9 1.2e-10 40.6 10.4 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF40498.1 - 6e-10 37.9 2.8 6.9e-10 37.7 1.9 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 CCF40498.1 - 0.00078 18.1 8.5 0.0018 16.9 6.0 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter DEAD PF00270.24 CCF40500.1 - 1.7e-12 47.1 0.0 2.1e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase CTP_transf_1 PF01148.15 CCF40501.1 - 2.1e-16 60.3 9.0 7.8e-15 55.2 2.3 2.0 1 1 1 2 2 2 2 Cytidylyltransferase family Nic96 PF04097.9 CCF40502.1 - 6.3e-188 625.7 0.0 7.9e-188 625.4 0.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 Nucleoporin_FG PF13634.1 CCF40502.1 - 3.3e-09 36.9 92.1 1.6e-08 34.7 32.9 3.4 2 1 1 3 3 3 3 Nucleoporin FG repeat region zf-C2H2_jaz PF12171.3 CCF40503.1 - 5e-05 23.3 1.7 5e-05 23.3 1.2 3.6 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 CCF40503.1 - 0.0022 18.2 0.9 0.0022 18.2 0.6 3.2 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-met PF12874.2 CCF40503.1 - 0.003 17.6 0.6 0.003 17.6 0.4 2.7 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 CCF40503.1 - 0.0031 17.5 1.0 0.0031 17.5 0.7 2.3 1 1 2 3 3 3 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.1 CCF40503.1 - 0.034 14.4 0.3 0.034 14.4 0.2 3.5 3 1 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CCF40503.1 - 0.72 10.2 0.1 0.72 10.2 0.1 3.1 3 0 0 3 3 3 0 Zinc-finger double domain Ran_BP1 PF00638.13 CCF40504.1 - 4e-50 168.9 1.6 6.8e-50 168.1 1.1 1.4 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.18 CCF40504.1 - 0.00092 18.9 0.3 0.0034 17.0 0.2 1.8 1 1 0 1 1 1 1 WH1 domain PS-DH PF14765.1 CCF40504.1 - 0.072 12.2 0.2 0.13 11.4 0.1 1.3 1 0 0 1 1 1 0 Polyketide synthase dehydratase FHIPEP PF00771.15 CCF40504.1 - 0.12 10.7 0.4 0.16 10.2 0.3 1.1 1 0 0 1 1 1 0 FHIPEP family Pox_MCEL PF03291.11 CCF40506.1 - 4.7e-66 222.9 0.0 9.8e-45 152.8 0.0 2.6 2 1 0 2 2 2 2 mRNA capping enzyme Methyltransf_12 PF08242.7 CCF40506.1 - 3.7e-09 36.9 0.0 0.0017 18.8 0.0 2.9 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.7 CCF40506.1 - 4.8e-08 33.3 0.0 3.5e-07 30.6 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF40506.1 - 9.8e-07 29.3 0.2 3.1e-06 27.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF40506.1 - 1.2e-06 28.2 0.0 2.4e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF40506.1 - 7.3e-06 26.2 0.0 1.9e-05 24.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF40506.1 - 7e-05 22.4 0.0 0.0014 18.2 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 CCF40506.1 - 0.00026 20.0 0.0 0.00044 19.3 0.0 1.3 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_4 PF02390.12 CCF40506.1 - 0.057 12.4 0.0 0.14 11.2 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_9 PF08003.6 CCF40506.1 - 0.17 10.5 0.0 0.36 9.4 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) RPN7 PF10602.4 CCF40507.1 - 4.2e-56 189.1 2.0 4.3e-56 189.0 0.3 1.8 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.22 CCF40507.1 - 1.8e-15 57.1 0.0 4.1e-15 55.9 0.0 1.6 1 0 0 1 1 1 1 PCI domain TPR_14 PF13428.1 CCF40507.1 - 0.45 11.2 4.5 0.92 10.3 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Aminotran_1_2 PF00155.16 CCF40508.1 - 5.2e-37 127.6 0.0 7.1e-37 127.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Pec_lyase_C PF00544.14 CCF40509.1 - 9.8e-44 149.2 0.9 1.7e-43 148.4 0.6 1.3 1 0 0 1 1 1 1 Pectate lyase DUF563 PF04577.9 CCF40509.1 - 0.14 12.0 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF563) Pyr_redox_3 PF13738.1 CCF40511.1 - 1.3e-28 100.4 0.0 1.8e-28 99.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 CCF40511.1 - 6.8e-10 37.7 0.0 1.2e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 CCF40511.1 - 4.6e-09 36.1 0.0 8.6e-08 32.0 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 CCF40511.1 - 7.2e-08 31.7 0.0 1.1e-06 27.7 0.0 2.2 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.12 CCF40511.1 - 1.3e-05 24.4 0.0 0.0016 17.5 0.0 2.3 2 0 0 2 2 2 1 Thi4 family DAO PF01266.19 CCF40511.1 - 0.00023 20.1 4.1 0.00088 18.2 0.1 3.0 1 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF40511.1 - 0.00028 20.8 0.2 0.29 10.9 0.1 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF40511.1 - 0.00086 19.6 0.0 2.5 8.5 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF40511.1 - 0.0011 18.8 0.9 3.4 7.4 0.1 3.8 4 0 0 4 4 4 1 FAD-NAD(P)-binding Mqo PF06039.10 CCF40511.1 - 0.0033 15.6 0.0 0.021 13.0 0.0 2.2 2 1 0 2 2 2 1 Malate:quinone oxidoreductase (Mqo) FAD_binding_2 PF00890.19 CCF40511.1 - 0.012 14.5 0.0 4.1 6.1 0.0 2.5 3 0 0 3 3 3 0 FAD binding domain Amino_oxidase PF01593.19 CCF40511.1 - 0.015 14.3 0.0 0.029 13.4 0.0 1.4 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Shikimate_DH PF01488.15 CCF40511.1 - 0.075 13.1 0.0 2.8 8.0 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Lactamase_B_2 PF12706.2 CCF40512.1 - 1.9e-16 60.1 0.2 2.6e-16 59.7 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 CCF40512.1 - 2.6e-07 30.4 0.4 4.7e-07 29.6 0.3 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Cu_amine_oxid PF01179.15 CCF40513.1 - 1.7e-169 563.9 0.0 2e-169 563.7 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.11 CCF40513.1 - 1.4e-22 79.6 0.1 2.9e-22 78.6 0.1 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.11 CCF40513.1 - 6.4e-15 55.0 0.0 1.1e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain MFS_1 PF07690.11 CCF40514.1 - 1e-36 126.3 26.6 6.5e-36 123.7 19.8 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF40514.1 - 2.7e-05 22.7 8.2 2.7e-05 22.7 5.7 1.9 2 0 0 2 2 2 1 MFS/sugar transport protein DUF4064 PF13273.1 CCF40514.1 - 5.3 7.2 9.0 1.1 9.4 0.3 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF4064) NfeD PF01957.13 CCF40514.1 - 8.6 6.4 11.4 7.6 6.6 1.2 3.9 2 2 2 4 4 4 0 NfeD-like C-terminal, partner-binding DUF1777 PF08648.7 CCF40515.1 - 0.0054 16.4 10.0 0.0054 16.4 6.9 4.2 3 1 1 4 4 4 1 Protein of unknown function (DUF1777) RAP1 PF07218.6 CCF40515.1 - 0.021 12.9 2.1 0.027 12.5 1.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Pex14_N PF04695.8 CCF40515.1 - 0.31 11.1 9.2 3.6 7.6 0.3 2.8 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2217 PF10265.4 CCF40515.1 - 0.93 8.1 4.7 1.5 7.4 3.2 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) MIP-T3 PF10243.4 CCF40515.1 - 8.3 4.7 13.4 0.46 8.8 5.6 1.6 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 Nop14 PF04147.7 CCF40516.1 - 0.05 11.5 8.4 0.069 11.0 5.8 1.1 1 0 0 1 1 1 0 Nop14-like family Merozoite_SPAM PF07133.6 CCF40516.1 - 0.1 12.4 10.0 0.18 11.6 6.9 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CobT PF06213.7 CCF40516.1 - 0.27 10.3 12.5 0.8 8.7 8.1 1.9 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT RNA_pol_3_Rpc31 PF11705.3 CCF40516.1 - 0.34 10.8 13.2 0.74 9.7 9.2 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Cwf_Cwc_15 PF04889.7 CCF40516.1 - 0.57 9.8 13.6 1.1 8.9 9.5 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Sigma70_ner PF04546.8 CCF40516.1 - 0.76 9.3 9.4 1.2 8.7 6.5 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region PBP1_TM PF14812.1 CCF40516.1 - 0.88 9.9 10.7 2.4 8.5 7.4 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Daxx PF03344.10 CCF40516.1 - 2.7 6.3 18.2 0.13 10.6 7.0 2.0 2 0 0 2 2 2 0 Daxx Family BTV_NS2 PF04514.7 CCF40516.1 - 3.5 6.4 5.6 5.4 5.7 3.9 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 CDC45 PF02724.9 CCF40516.1 - 4.2 5.2 9.1 6.2 4.7 6.3 1.1 1 0 0 1 1 1 0 CDC45-like protein RXT2_N PF08595.6 CCF40516.1 - 4.5 7.0 8.1 8.5 6.1 5.6 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.7 CCF40516.1 - 4.5 6.4 12.4 6.9 5.8 8.6 1.2 1 0 0 1 1 1 0 NOA36 protein DLH PF01738.13 CCF40517.1 - 1.2e-05 24.6 0.0 1.3e-05 24.6 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family ADH_zinc_N PF00107.21 CCF40518.1 - 7.4e-26 90.2 0.2 1.3e-25 89.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF40518.1 - 7.2e-17 62.4 0.0 1.3e-16 61.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF40518.1 - 5.1e-11 42.2 0.0 1.6e-10 40.6 0.0 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain p450 PF00067.17 CCF40519.1 - 4.6e-39 134.2 0.0 8.7e-39 133.3 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Transp_cyt_pur PF02133.10 CCF40520.1 - 1.7e-16 59.8 2.1 2e-16 59.6 1.5 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin XRN_N PF03159.13 CCF40522.1 - 3.7e-103 343.9 0.0 6.3e-103 343.2 0.0 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus CAF1C_H4-bd PF12265.3 CCF40523.1 - 1.9e-28 98.1 0.2 3.9e-28 97.1 0.1 1.6 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.27 CCF40523.1 - 1.1e-21 75.7 0.0 1.3e-06 27.9 0.0 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat Cpn60_TCP1 PF00118.19 CCF40524.1 - 6e-139 463.7 2.1 6.8e-139 463.6 1.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PP1_inhibitor PF05361.7 CCF40524.1 - 0.031 13.9 0.1 0.082 12.5 0.1 1.8 1 0 0 1 1 1 0 PKC-activated protein phosphatase-1 inhibitor MFS_1 PF07690.11 CCF40525.1 - 4.5e-05 22.3 21.7 5e-05 22.1 13.8 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily CbtA PF09490.5 CCF40525.1 - 0.011 15.1 6.1 0.025 13.8 0.2 2.3 1 1 1 2 2 2 0 Probable cobalt transporter subunit (CbtA) zf-C2H2_4 PF13894.1 CCF40528.1 - 0.00012 22.1 5.4 0.012 15.8 0.1 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CCF40528.1 - 0.014 15.5 0.3 0.043 13.9 0.1 1.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 CCF40528.1 - 3 8.3 10.5 0.91 9.9 0.4 3.3 3 0 0 3 3 3 0 Zinc finger, C2H2 type Fungal_trans_2 PF11951.3 CCF40529.1 - 2.8e-10 39.3 0.7 4.1e-10 38.8 0.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain MutS_V PF00488.16 CCF40531.1 - 8.1e-73 244.6 0.1 1.3e-72 244.0 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 CCF40531.1 - 3.8e-32 111.7 0.6 3.8e-32 111.7 0.4 2.4 2 1 0 2 2 2 1 MutS domain III MutS_IV PF05190.13 CCF40531.1 - 1.5e-07 31.4 0.0 4.3e-07 30.0 0.0 1.8 1 0 0 1 1 1 1 MutS family domain IV MobB PF03205.9 CCF40531.1 - 0.12 12.1 0.1 17 5.1 0.0 3.2 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B MIP-T3 PF10243.4 CCF40532.1 - 0.3 9.5 38.8 0.38 9.1 26.9 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 ROS_MUCR PF05443.6 CCF40533.1 - 0.0019 18.0 0.5 0.02 14.6 0.1 2.8 2 0 0 2 2 2 1 ROS/MUCR transcriptional regulator protein DUF218 PF02698.12 CCF40535.1 - 1e-08 34.8 0.0 1.8e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 DUF218 domain Mur_ligase_M PF08245.7 CCF40536.1 - 0.00013 22.0 0.7 0.0007 19.6 0.5 2.1 1 1 0 1 1 1 1 Mur ligase middle domain Glyco_hydro_28 PF00295.12 CCF40537.1 - 3.6e-31 108.3 2.3 4.9e-31 107.9 1.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.1 CCF40537.1 - 0.032 13.9 18.8 0.42 10.3 13.0 2.4 1 1 0 1 1 1 0 Right handed beta helix region Zn_ribbon_recom PF13408.1 CCF40537.1 - 0.2 11.9 3.7 0.76 10.0 0.1 3.0 2 1 1 3 3 3 0 Recombinase zinc beta ribbon domain MGC-24 PF05283.6 CCF40538.1 - 0.037 13.8 0.5 0.056 13.2 0.4 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) Spt20 PF12090.3 CCF40538.1 - 0.83 8.9 7.4 0.73 9.1 2.3 2.0 2 0 0 2 2 2 0 Spt20 family DUF533 PF04391.7 CCF40538.1 - 1.3 8.3 11.8 0.2 11.0 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF533) DUF3306 PF11748.3 CCF40538.1 - 4.7 7.8 9.2 5.5 7.6 3.6 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3306) Host_attach PF10116.4 CCF40538.1 - 7.1 6.8 7.7 38 4.4 0.0 2.2 2 0 0 2 2 2 0 Protein required for attachment to host cells Fungal_trans PF04082.13 CCF40539.1 - 1.3e-20 73.4 0.0 2.2e-20 72.6 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain TPR_11 PF13414.1 CCF40541.1 - 0.1 12.2 0.2 0.18 11.4 0.1 1.4 1 0 0 1 1 1 0 TPR repeat Zn_clus PF00172.13 CCF40542.1 - 4.6e-09 36.0 9.0 7.3e-09 35.4 6.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.17 CCF40543.1 - 1.2e-56 192.2 0.0 1.4e-56 191.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Anp1 PF03452.9 CCF40544.1 - 3.2e-107 357.7 1.7 6e-107 356.8 0.0 1.9 2 0 0 2 2 2 1 Anp1 DUF2146 PF10220.4 CCF40544.1 - 0.48 8.3 9.6 0.59 8.0 6.6 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) DUF2201_N PF13203.1 CCF40544.1 - 1.9 7.5 10.1 3 6.9 7.0 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain Sec7 PF01369.15 CCF40545.1 - 4.3e-62 209.1 0.0 8.2e-62 208.2 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.2 CCF40545.1 - 2.2e-17 62.9 0.0 2.3e-11 43.4 0.0 3.0 2 0 0 2 2 2 2 Guanine nucleotide exchange factor in Golgi transport N-terminal RRM_1 PF00076.17 CCF40546.1 - 2.6e-25 87.8 0.5 1e-11 44.2 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF40546.1 - 3.9e-18 65.2 0.1 4e-08 33.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF40546.1 - 2.2e-17 62.6 0.0 3.4e-10 39.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 CCF40546.1 - 0.03 14.0 0.1 5.5 6.8 0.0 2.6 2 1 0 2 2 2 0 Limkain b1 ATP-synt_D PF01813.12 CCF40547.1 - 2.6e-64 216.4 2.2 3.2e-64 216.1 1.5 1.1 1 0 0 1 1 1 1 ATP synthase subunit D SYCE1 PF15233.1 CCF40547.1 - 0.42 10.5 3.2 0.39 10.6 0.5 2.1 2 1 0 2 2 2 0 Synaptonemal complex central element protein 1 Viral_P18 PF04521.8 CCF40547.1 - 0.73 9.2 4.1 3.8 6.9 0.1 2.3 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein NRDE-2 PF08424.5 CCF40548.1 - 1.2e-06 27.6 2.4 0.04 12.7 0.1 3.6 1 1 3 4 4 4 3 NRDE-2, necessary for RNA interference Suf PF05843.9 CCF40548.1 - 0.00012 21.8 0.0 0.00065 19.5 0.0 1.9 1 1 1 2 2 2 1 Suppressor of forked protein (Suf) Egg_lysin PF01303.12 CCF40548.1 - 0.064 13.2 0.4 0.31 11.0 0.1 2.2 2 0 0 2 2 2 0 Egg lysin (Sperm-lysin) KorB PF08535.5 CCF40548.1 - 0.15 12.1 0.0 0.28 11.3 0.0 1.3 1 0 0 1 1 1 0 KorB domain DUF2183 PF09949.4 CCF40549.1 - 4.8e-31 106.6 0.0 1.5e-30 105.1 0.0 1.9 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) LNS2 PF08235.8 CCF40549.1 - 0.015 14.8 0.0 0.036 13.6 0.0 1.6 1 0 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) AIF_C PF14721.1 CCF40549.1 - 0.34 11.1 1.9 0.42 10.8 0.1 2.0 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Mito_fiss_reg PF05308.6 CCF40549.1 - 3.9 6.7 14.9 3.1 7.0 5.5 2.9 2 0 0 2 2 2 0 Mitochondrial fission regulator HTH_32 PF13565.1 CCF40550.1 - 0.028 15.1 3.3 0.028 15.1 2.3 2.0 1 1 1 2 2 2 0 Homeodomain-like domain Upf2 PF04050.9 CCF40550.1 - 4.5 6.9 9.1 16 5.2 6.3 1.9 1 1 0 1 1 1 0 Up-frameshift suppressor 2 SMP PF04927.7 CCF40551.1 - 2e-13 50.0 0.8 2.9e-09 36.7 0.0 2.5 1 1 1 2 2 2 2 Seed maturation protein AIF-MLS PF14962.1 CCF40551.1 - 3.5 7.2 8.6 2.3 7.8 4.9 1.4 1 1 0 1 1 1 0 Mitochondria Localisation Sequence OmdA PF13376.1 CCF40552.1 - 2.3e-21 75.1 0.7 2.8e-21 74.9 0.5 1.1 1 0 0 1 1 1 1 Bacteriocin-protection, YdeI or OmpD-Associated Sugar_tr PF00083.19 CCF40553.1 - 2.3e-88 296.7 20.3 2.9e-88 296.4 14.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF40553.1 - 3.2e-17 62.2 60.3 8.4e-14 51.0 23.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TauD PF02668.11 CCF40554.1 - 1.2e-43 149.6 0.2 1.5e-43 149.3 0.2 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CAP59_mtransfer PF11735.3 CCF40555.1 - 3.8e-12 45.9 0.0 5.7e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 D-ser_dehydrat PF14031.1 CCF40557.1 - 1.8e-27 95.3 0.0 3e-27 94.6 0.0 1.4 1 0 0 1 1 1 1 Putative serine dehydratase domain Ala_racemase_N PF01168.15 CCF40557.1 - 2.9e-10 40.0 0.0 4.8e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain RseC_MucC PF04246.7 CCF40557.1 - 0.13 11.8 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Fungal_trans_2 PF11951.3 CCF40558.1 - 2.4e-41 141.6 6.6 3.4e-41 141.1 4.6 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF40558.1 - 7.3e-05 22.5 9.0 0.00011 22.0 6.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.11 CCF40559.1 - 1.3e-14 53.7 48.1 1.9e-13 49.8 32.2 2.9 1 1 0 1 1 1 1 Major Facilitator Superfamily P5-ATPase PF12409.3 CCF40559.1 - 0.41 10.4 2.7 0.9 9.4 1.9 1.5 1 0 0 1 1 1 0 P5-type ATPase cation transporter MFS_1 PF07690.11 CCF40560.1 - 9.4e-38 129.8 37.7 8.1e-32 110.2 15.5 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.3 CCF40560.1 - 1.8 6.9 12.6 0.14 10.6 3.9 2.6 2 1 1 3 3 3 0 Vacuole effluxer Atg22 like F-box-like PF12937.2 CCF40562.1 - 8.9e-06 25.3 2.0 1.6e-05 24.4 1.4 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF40562.1 - 1.1e-05 24.9 1.8 1.9e-05 24.1 0.9 1.7 1 1 1 2 2 2 1 F-box domain PRANC PF09372.5 CCF40562.1 - 0.014 15.2 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 PRANC domain DUF3079 PF11278.3 CCF40562.1 - 0.023 14.2 0.7 0.034 13.6 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3079) F-box-like_2 PF13013.1 CCF40562.1 - 0.049 13.3 0.1 0.054 13.2 0.1 1.2 1 0 0 1 1 1 0 F-box-like domain Dynamin_N PF00350.18 CCF40563.1 - 4.1e-08 33.2 0.0 5.4e-08 32.8 0.0 1.4 1 1 0 1 1 1 1 Dynamin family ABC_tran PF00005.22 CCF40563.1 - 0.00016 21.9 0.0 0.00036 20.8 0.0 1.5 1 1 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.18 CCF40563.1 - 0.00018 21.4 0.0 0.00037 20.4 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CCF40563.1 - 0.00045 20.7 0.0 0.0011 19.4 0.0 1.7 2 0 0 2 2 1 1 Miro-like protein DUF258 PF03193.11 CCF40563.1 - 0.0015 17.7 0.0 0.0021 17.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 DUF87 PF01935.12 CCF40563.1 - 0.0019 18.0 0.0 0.012 15.4 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function DUF87 AIG1 PF04548.11 CCF40563.1 - 0.0039 16.3 0.0 0.0063 15.6 0.0 1.3 1 0 0 1 1 1 1 AIG1 family AAA_17 PF13207.1 CCF40563.1 - 0.0088 16.8 0.0 0.015 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain IIGP PF05049.8 CCF40563.1 - 0.012 14.3 0.1 0.036 12.8 0.1 1.7 1 1 1 2 2 2 0 Interferon-inducible GTPase (IIGP) ArgK PF03308.11 CCF40563.1 - 0.019 13.7 0.0 0.032 13.0 0.0 1.3 1 0 0 1 1 1 0 ArgK protein AAA_16 PF13191.1 CCF40563.1 - 0.05 13.5 0.1 0.1 12.5 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.1 CCF40563.1 - 0.064 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Adeno_IVa2 PF02456.10 CCF40563.1 - 0.071 11.7 0.0 0.1 11.2 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_29 PF13555.1 CCF40563.1 - 0.11 12.1 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Peptidase_S28 PF05577.7 CCF40564.1 - 2.9e-44 151.3 0.9 3.3e-43 147.8 0.7 2.0 1 1 0 1 1 1 1 Serine carboxypeptidase S28 DUF2920 PF11144.3 CCF40564.1 - 0.00024 20.2 0.0 0.00033 19.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2920) Abhydrolase_6 PF12697.2 CCF40564.1 - 0.0026 17.6 0.2 0.019 14.8 0.2 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family adh_short PF00106.20 CCF40565.1 - 5.9e-18 65.3 0.9 1.4e-17 64.0 0.4 1.8 2 1 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 CCF40565.1 - 1.7e-08 34.3 0.2 3.3e-08 33.4 0.1 1.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF40565.1 - 9e-07 28.5 0.0 1.3e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Chlam_OMP3 PF03503.8 CCF40567.1 - 0.076 13.2 0.7 0.14 12.3 0.5 1.4 1 0 0 1 1 1 0 Chlamydia cysteine-rich outer membrane protein 3 LPAM_1 PF08139.7 CCF40567.1 - 0.49 10.7 1.7 0.89 9.8 1.2 1.4 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site WD40 PF00400.27 CCF40568.1 - 0.0079 16.0 4.4 7.5 6.6 0.0 5.5 5 0 0 5 5 5 2 WD domain, G-beta repeat Pkinase PF00069.20 CCF40569.1 - 2e-38 132.0 0.0 2.4e-38 131.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF40569.1 - 2.3e-28 98.9 0.0 2.9e-28 98.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF40569.1 - 0.00026 20.0 0.0 0.00039 19.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 CCF40569.1 - 0.047 12.7 0.0 0.071 12.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CCF40569.1 - 0.11 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family PPP4R2 PF09184.6 CCF40572.1 - 0.096 12.2 7.1 0.099 12.1 4.9 1.0 1 0 0 1 1 1 0 PPP4R2 BSP_II PF05432.6 CCF40572.1 - 0.37 10.0 6.4 0.36 10.0 4.4 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Nucleoplasmin PF03066.10 CCF40572.1 - 0.47 9.9 5.4 0.48 9.9 3.7 1.1 1 0 0 1 1 1 0 Nucleoplasmin TFIIE-A_C-term PF11521.3 CCF40572.1 - 0.68 9.9 5.7 0.75 9.7 4.0 1.1 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha Daxx PF03344.10 CCF40572.1 - 1.9 6.8 6.8 1.9 6.8 4.7 1.0 1 0 0 1 1 1 0 Daxx Family PBP_sp32 PF07222.7 CCF40572.1 - 2.3 7.3 5.9 2.5 7.2 4.1 1.0 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Myc_N PF01056.13 CCF40572.1 - 5.6 6.0 7.2 6.1 5.8 5.0 1.0 1 0 0 1 1 1 0 Myc amino-terminal region Ribosomal_60s PF00428.14 CCF40572.1 - 5.6 7.4 9.5 6.1 7.3 6.6 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein Ribosomal_L40e PF01020.12 CCF40574.1 - 6.8e-31 105.6 9.6 9.2e-31 105.2 6.6 1.2 1 0 0 1 1 1 1 Ribosomal L40e family Yip1 PF04893.12 CCF40575.1 - 3.6e-11 42.8 16.6 3.6e-11 42.8 11.5 1.4 1 1 0 1 1 1 1 Yip1 domain Rhodanese PF00581.15 CCF40576.1 - 8.6e-11 42.1 0.0 1.3e-10 41.6 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain CLPTM1 PF05602.7 CCF40577.1 - 7.3e-150 499.4 0.0 9.5e-150 499.1 0.0 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) MFS_1 PF07690.11 CCF40578.1 - 2.4e-15 56.1 32.3 8.2e-13 47.7 23.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.11 CCF40578.1 - 3.2e-06 26.7 7.1 6.1e-06 25.8 4.0 2.1 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 DUF2788 PF10981.3 CCF40578.1 - 1.7 8.4 6.6 5.3 6.9 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2788) Sugar_tr PF00083.19 CCF40579.1 - 1.3e-101 340.4 21.3 1.5e-101 340.2 14.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF40579.1 - 3e-19 68.9 40.3 8.7e-16 57.5 9.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CCF40579.1 - 0.00022 19.7 12.2 0.00022 19.7 8.5 3.6 2 1 0 3 3 3 2 MFS/sugar transport protein Arch_ATPase PF01637.13 CCF40580.1 - 7.3e-06 25.8 0.1 1.5e-05 24.7 0.1 1.5 1 1 0 1 1 1 1 Archaeal ATPase AAA_16 PF13191.1 CCF40580.1 - 0.0003 20.8 5.6 0.18 11.7 0.0 3.7 3 1 1 4 4 4 2 AAA ATPase domain AAA_25 PF13481.1 CCF40580.1 - 0.0039 16.6 0.2 0.016 14.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.8 CCF40580.1 - 0.011 14.7 0.0 0.022 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ATP-synt_ab PF00006.20 CCF40580.1 - 0.056 12.9 0.0 0.2 11.1 0.0 1.8 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF632 PF04782.7 CCF40580.1 - 0.056 12.5 0.2 0.089 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF632) KaiC PF06745.8 CCF40580.1 - 0.062 12.4 1.2 0.14 11.2 0.8 1.6 1 1 0 1 1 1 0 KaiC Miro PF08477.8 CCF40580.1 - 0.079 13.4 0.6 1.4 9.4 0.4 2.5 1 1 0 1 1 1 0 Miro-like protein AAA_22 PF13401.1 CCF40580.1 - 0.082 13.0 0.5 0.28 11.3 0.3 1.9 1 1 0 1 1 1 0 AAA domain AAA PF00004.24 CCF40580.1 - 0.1 12.7 0.1 0.3 11.2 0.1 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) E1-E2_ATPase PF00122.15 CCF40581.1 - 3.6e-56 189.7 2.1 6.3e-56 188.9 1.5 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CCF40581.1 - 2.5e-25 89.0 2.1 2.5e-25 89.0 1.4 3.0 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CCF40581.1 - 2.1e-24 87.1 0.0 8.6e-24 85.1 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF40581.1 - 1.5e-20 72.9 0.0 3.9e-20 71.6 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 CCF40581.1 - 2.1e-15 57.3 0.0 4e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 CCF40581.1 - 1.1e-08 34.3 0.0 2.9e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 CCF40581.1 - 1.3e-05 24.9 0.6 0.00026 20.6 0.5 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3325 PF11804.3 CCF40581.1 - 0.013 15.4 1.7 3.6 7.5 0.0 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3325) DUF4234 PF14018.1 CCF40581.1 - 0.12 12.1 0.8 0.62 9.8 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4234) NACHT PF05729.7 CCF40582.1 - 1.3e-06 28.2 0.0 2.9e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 CCF40582.1 - 6.3e-05 23.0 0.0 0.00019 21.4 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CCF40582.1 - 0.00042 20.4 0.0 0.0017 18.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain KAP_NTPase PF07693.9 CCF40582.1 - 0.0016 17.5 0.1 0.021 13.8 0.0 2.2 2 0 0 2 2 2 1 KAP family P-loop domain ABC_tran PF00005.22 CCF40582.1 - 0.021 15.0 0.0 0.059 13.6 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA_10 PF12846.2 CCF40582.1 - 0.042 13.2 0.0 0.12 11.7 0.0 1.8 2 0 0 2 2 2 0 AAA-like domain Ank_2 PF12796.2 CCF40582.1 - 0.057 13.7 0.1 0.13 12.6 0.1 1.6 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Zeta_toxin PF06414.7 CCF40582.1 - 0.073 12.1 0.0 0.14 11.2 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.1 CCF40582.1 - 0.096 12.2 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 CCF40582.1 - 0.1 12.7 0.0 0.47 10.6 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CCF40582.1 - 0.14 12.9 0.3 0.84 10.4 0.0 2.4 2 1 0 2 2 2 0 AAA domain Fungal_trans PF04082.13 CCF40583.1 - 1.7e-05 23.8 0.0 2.8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF3772 PF12607.3 CCF40583.1 - 0.028 14.0 0.1 0.091 12.4 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3772) Nup188 PF10487.4 CCF40585.1 - 9.7e-08 30.4 0.0 1.9e-07 29.4 0.0 1.5 1 1 0 1 1 1 1 Nucleoporin subcomplex protein binding to Pom34 Antimicrobial15 PF08110.7 CCF40585.1 - 0.2 11.7 3.2 1.2 9.3 0.1 2.8 2 0 0 2 2 2 0 Ocellatin family SnoaL_4 PF13577.1 CCF40588.1 - 6.1e-09 35.8 0.0 9e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 SnoaL-like domain Ras PF00071.17 CCF40589.1 - 5.7e-56 188.3 0.0 6.5e-56 188.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF40589.1 - 9.8e-16 58.3 0.0 1.5e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CCF40589.1 - 3.7e-07 29.5 0.0 6e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 CCF40589.1 - 0.00092 18.4 0.0 0.0013 17.9 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 CCF40589.1 - 0.035 13.2 0.0 0.046 12.8 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PduV-EutP PF10662.4 CCF40589.1 - 0.15 11.5 0.0 11 5.4 0.0 2.5 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Glyco_hydro_47 PF01532.15 CCF40590.1 - 1.2e-156 521.9 0.0 1.4e-156 521.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Daxx PF03344.10 CCF40591.1 - 0.12 10.7 4.9 0.15 10.5 3.4 1.0 1 0 0 1 1 1 0 Daxx Family ATP-synt_E PF05680.7 CCF40591.1 - 2.1 8.3 5.1 0.37 10.7 1.1 1.5 2 0 0 2 2 2 0 ATP synthase E chain FYVE_2 PF02318.11 CCF40591.1 - 5.4 6.9 7.3 21 5.0 0.0 3.0 3 0 0 3 3 3 0 FYVE-type zinc finger ADH_zinc_N_2 PF13602.1 CCF40592.1 - 4.1e-09 37.3 0.1 4.2e-09 37.3 0.0 1.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Amino_oxidase PF01593.19 CCF40593.1 - 1.3e-12 47.5 0.1 2e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase PALP PF00291.20 CCF40595.1 - 1.9e-22 79.8 0.1 2.1e-22 79.7 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Cation_efflux PF01545.16 CCF40596.1 - 1e-40 139.6 2.7 3e-31 108.5 0.0 2.0 2 0 0 2 2 2 2 Cation efflux family DUF3608 PF12257.3 CCF40597.1 - 8.1e-70 234.9 0.0 1.6e-69 233.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3608) DEP PF00610.16 CCF40597.1 - 4e-28 96.9 0.3 7.6e-28 96.0 0.2 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Exo_endo_phos PF03372.18 CCF40598.1 - 2.4e-26 93.1 0.1 4.1e-26 92.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BBS2_Mid PF14783.1 CCF40598.1 - 0.027 14.2 0.1 0.14 11.9 0.0 2.3 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Mito_carr PF00153.22 CCF40599.1 - 1.2e-33 114.6 0.2 3.6e-24 84.2 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Fungal_trans PF04082.13 CCF40600.1 - 7e-25 87.3 0.5 1.4e-24 86.4 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF40600.1 - 1.6e-09 37.5 8.2 3.3e-09 36.4 5.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RNA_pol_Rpb2_7 PF04560.15 CCF40600.1 - 0.06 13.6 0.0 0.25 11.6 0.0 1.9 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 7 ABC_membrane PF00664.18 CCF40601.1 - 0.00088 18.7 0.2 0.0027 17.1 0.1 1.7 1 1 0 1 1 1 1 ABC transporter transmembrane region PBP1_TM PF14812.1 CCF40601.1 - 0.026 14.8 2.6 0.05 13.9 1.8 1.6 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Abhydrolase_6 PF12697.2 CCF40602.1 - 1.9e-27 96.6 0.8 2.2e-27 96.4 0.6 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF40602.1 - 2.9e-15 56.3 0.0 7.2e-15 55.0 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF40602.1 - 0.00057 19.5 0.0 0.14 11.6 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold DUF900 PF05990.7 CCF40602.1 - 0.0017 17.7 0.0 0.0022 17.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.8 CCF40602.1 - 0.0038 16.8 0.0 0.0073 15.9 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_8 PF06259.7 CCF40602.1 - 0.0078 15.7 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase DLH PF01738.13 CCF40602.1 - 0.036 13.3 0.0 0.056 12.7 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family SOG2 PF10428.4 CCF40604.1 - 0.04 12.5 5.3 0.038 12.6 3.7 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Neisseria_TspB PF05616.8 CCF40604.1 - 4.2 5.6 9.4 5.8 5.1 6.5 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein DUF605 PF04652.11 CCF40604.1 - 9.5 5.5 17.6 10 5.3 12.2 1.1 1 0 0 1 1 1 0 Vta1 like NS3_envE PF02723.9 CCF40605.1 - 0.023 14.6 0.6 0.2 11.6 0.5 2.4 2 0 0 2 2 2 0 Non-structural protein NS3/Small envelope protein E IPT PF01745.11 CCF40605.1 - 0.03 13.5 0.0 0.78 8.8 0.1 2.1 2 0 0 2 2 2 0 Isopentenyl transferase Tmpp129 PF10272.4 CCF40605.1 - 0.31 9.7 6.1 0.16 10.6 0.6 2.0 1 1 0 2 2 2 0 Putative transmembrane protein precursor Mem_trans PF03547.13 CCF40607.1 - 1.4e-27 96.0 1.9 2e-27 95.4 1.3 1.2 1 0 0 1 1 1 1 Membrane transport protein NapE PF06796.6 CCF40607.1 - 2.6 7.4 6.1 44 3.4 1.9 3.5 2 1 1 3 3 3 0 Periplasmic nitrate reductase protein NapE Scm3 PF10384.4 CCF40608.1 - 0.047 13.1 0.1 0.11 11.9 0.0 1.6 1 0 0 1 1 1 0 Centromere protein Scm3 Peptidase_C14 PF00656.17 CCF40609.1 - 2.8e-49 168.0 0.0 7.2e-43 147.0 0.0 2.0 1 1 1 2 2 2 2 Caspase domain GST_N_3 PF13417.1 CCF40610.1 - 1.8e-13 50.5 0.0 3e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 CCF40610.1 - 2.4e-10 40.2 0.0 3.9e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 CCF40610.1 - 3.7e-10 39.8 0.0 6.3e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 CCF40610.1 - 3e-09 36.6 0.3 6.3e-09 35.5 0.2 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 CCF40610.1 - 6.6e-07 29.2 0.0 9.8e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 CCF40610.1 - 0.0054 17.1 0.0 0.0079 16.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain MBOAT PF03062.14 CCF40611.1 - 1.4e-10 40.8 4.7 1.4e-10 40.8 3.3 2.2 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family SUZ PF12752.2 CCF40612.1 - 1.1e-14 54.7 4.3 1.1e-14 54.7 3.0 2.9 3 0 0 3 3 3 1 SUZ domain R3H PF01424.17 CCF40612.1 - 1.7e-07 30.8 0.1 3.6e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 R3H domain DUF4603 PF15376.1 CCF40612.1 - 0.32 8.1 5.9 0.44 7.6 4.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) Transferase PF02458.10 CCF40613.1 - 0.0022 16.5 0.0 0.0028 16.1 0.0 1.1 1 0 0 1 1 1 1 Transferase family DUF4531 PF15041.1 CCF40613.1 - 0.13 11.9 0.0 0.73 9.5 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4531) Fungal_trans PF04082.13 CCF40614.1 - 2.9e-15 55.8 0.0 4.5e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Methyltransf_25 PF13649.1 CCF40615.1 - 2.3e-14 53.5 0.0 4.3e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF40615.1 - 2.8e-11 43.7 0.0 7.6e-11 42.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF40615.1 - 2e-08 34.1 0.0 3.6e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF40615.1 - 3.8e-08 33.8 0.0 7e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF40615.1 - 1.7e-07 31.2 0.0 4.3e-07 29.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF40615.1 - 8.8e-07 29.3 0.0 1.7e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF40615.1 - 1.5e-06 27.8 0.0 2.9e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF40615.1 - 8.1e-06 25.1 0.0 1.3e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.9 CCF40615.1 - 0.043 13.2 0.0 0.19 11.0 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_8 PF05148.10 CCF40615.1 - 0.053 13.1 0.0 0.084 12.4 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_32 PF13679.1 CCF40615.1 - 0.065 12.9 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.14 CCF40615.1 - 0.086 12.8 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase DnaJ PF00226.26 CCF40616.1 - 1.2e-08 34.5 0.1 2.2e-08 33.7 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Zn_clus PF00172.13 CCF40617.1 - 1.4e-06 28.0 8.7 2.1e-06 27.5 6.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF40617.1 - 0.04 12.7 0.0 0.063 12.1 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain MFS_1 PF07690.11 CCF40618.1 - 5.4e-12 45.0 41.9 5.4e-12 45.0 29.0 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 CCF40618.1 - 7.4e-06 25.5 3.9 7.4e-06 25.5 2.7 2.6 2 1 0 2 2 2 1 Ion channel regulatory protein UNC-93 AIRS_C PF02769.17 CCF40619.1 - 2.5e-29 102.2 0.0 3e-29 102.0 0.0 1.1 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.19 CCF40619.1 - 1e-10 41.6 0.2 2.3e-10 40.5 0.1 1.6 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain IDO PF01231.13 CCF40622.1 - 9e-41 139.6 0.0 1.2e-40 139.2 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase MFS_1 PF07690.11 CCF40623.1 - 3.3e-39 134.5 37.7 3.3e-39 134.5 26.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily HTH_psq PF05225.11 CCF40624.1 - 0.041 13.4 0.0 0.06 12.9 0.0 1.3 1 0 0 1 1 1 0 helix-turn-helix, Psq domain Dicty_REP PF05086.7 CCF40625.1 - 0.037 11.7 8.9 0.056 11.1 6.2 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FTHFS PF01268.14 CCF40626.1 - 2.2e-258 857.8 0.3 2.5e-258 857.6 0.2 1.0 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase DUF3563 PF12086.3 CCF40626.1 - 0.05 13.3 0.1 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3563) SNARE PF05739.14 CCF40627.1 - 1.4e-19 69.5 4.4 1.5e-19 69.3 1.6 2.2 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 CCF40627.1 - 2.1e-13 50.3 4.8 3e-12 46.6 0.2 2.3 2 0 0 2 2 2 2 Syntaxin MCPsignal PF00015.16 CCF40627.1 - 0.0077 15.7 8.3 0.18 11.3 1.0 2.5 3 0 0 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain Med9 PF07544.8 CCF40627.1 - 1.2 8.8 5.2 25 4.7 0.0 3.4 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 IncA PF04156.9 CCF40627.1 - 2.4 7.7 11.5 14 5.2 0.2 3.3 3 0 0 3 3 3 0 IncA protein DNA_repr_REX1B PF14966.1 CCF40627.1 - 4 7.8 6.8 0.82 10.0 0.1 2.8 3 0 0 3 3 3 0 DNA repair REX1-B PPR_3 PF13812.1 CCF40628.1 - 0.08 13.2 0.4 12 6.4 0.0 3.6 4 0 0 4 4 4 0 Pentatricopeptide repeat domain PPR_2 PF13041.1 CCF40628.1 - 0.12 12.4 0.1 1.3 9.0 0.0 2.3 2 0 0 2 2 2 0 PPR repeat family COX7a PF02238.10 CCF40629.1 - 0.027 14.1 0.2 0.043 13.5 0.1 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIIa Clathrin_lg_ch PF01086.12 CCF40630.1 - 6.3e-72 242.1 5.1 7.1e-72 241.9 3.5 1.0 1 0 0 1 1 1 1 Clathrin light chain ATP-synt_B PF00430.13 CCF40630.1 - 0.7 9.6 7.9 1.2 8.9 5.5 1.3 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) CTD_bind PF04818.8 CCF40631.1 - 2.8e-20 72.3 0.3 8.4e-20 70.7 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CTK3 PF12243.3 CCF40631.1 - 0.026 14.1 0.0 0.052 13.1 0.0 1.5 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 ABC_membrane PF00664.18 CCF40632.1 - 6.7e-44 150.3 7.1 8.3e-44 150.0 4.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 CCF40632.1 - 0.002 18.4 0.4 0.0045 17.2 0.0 1.8 2 0 0 2 2 2 1 ABC transporter AAA_29 PF13555.1 CCF40632.1 - 0.039 13.4 0.0 0.09 12.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_17 PF13207.1 CCF40632.1 - 0.063 14.0 0.8 0.13 13.0 0.6 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CCF40632.1 - 0.45 10.4 2.0 0.62 10.0 0.1 2.0 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.22 CCF40634.1 - 7.4e-19 68.4 0.0 1.4e-18 67.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 CCF40634.1 - 5.8e-08 33.0 0.0 0.0057 16.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.14 CCF40634.1 - 3.5e-05 23.1 0.0 0.063 12.5 0.0 2.2 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 CCF40634.1 - 0.00033 20.7 0.2 0.00095 19.3 0.1 1.8 1 1 0 1 1 1 1 AAA domain T2SE PF00437.15 CCF40634.1 - 0.0027 16.6 0.1 0.0045 15.9 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_membrane PF00664.18 CCF40634.1 - 0.0037 16.7 8.4 0.019 14.3 0.6 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_10 PF12846.2 CCF40634.1 - 0.0037 16.7 0.7 1 8.6 0.1 2.4 2 0 0 2 2 2 1 AAA-like domain AAA_16 PF13191.1 CCF40634.1 - 0.0045 16.9 0.2 0.024 14.6 0.1 2.2 2 1 0 2 2 2 1 AAA ATPase domain UPF0079 PF02367.12 CCF40634.1 - 0.0058 16.2 0.3 0.011 15.3 0.2 1.4 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 AAA_29 PF13555.1 CCF40634.1 - 0.0098 15.4 0.6 0.03 13.8 0.4 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain Arch_ATPase PF01637.13 CCF40634.1 - 0.015 15.0 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase MobB PF03205.9 CCF40634.1 - 0.026 14.2 0.5 0.058 13.1 0.4 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.14 CCF40634.1 - 0.03 13.7 1.2 0.051 13.0 0.8 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.13 CCF40634.1 - 0.036 13.5 0.2 0.085 12.3 0.1 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family NB-ARC PF00931.17 CCF40634.1 - 0.04 12.7 0.0 0.067 12.0 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_33 PF13671.1 CCF40634.1 - 0.048 13.5 0.1 0.093 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 CCF40634.1 - 0.051 13.5 0.1 0.11 12.3 0.0 1.7 2 0 0 2 2 1 0 50S ribosome-binding GTPase AAA_23 PF13476.1 CCF40634.1 - 0.052 13.8 0.2 0.091 13.0 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 CCF40634.1 - 0.063 12.6 0.2 0.23 10.8 0.1 1.9 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 CCF40634.1 - 0.073 12.2 0.1 0.13 11.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_11 PF13086.1 CCF40634.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 CCF40634.1 - 0.14 11.8 0.2 0.26 10.9 0.1 1.4 1 0 0 1 1 1 0 NACHT domain PduV-EutP PF10662.4 CCF40634.1 - 0.14 11.6 0.3 0.29 10.6 0.2 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TrwB_AAD_bind PF10412.4 CCF40634.1 - 0.15 10.6 0.3 0.27 9.8 0.2 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain NTPase_1 PF03266.10 CCF40634.1 - 0.32 10.6 1.7 1.3 8.7 0.2 2.1 2 0 0 2 2 2 0 NTPase GST_N PF02798.15 CCF40635.1 - 6.1e-08 32.7 0.0 1.1e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 CCF40635.1 - 1e-07 31.7 0.0 1.8e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 CCF40635.1 - 1.7e-06 28.1 0.0 3.9e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 CCF40635.1 - 5.6e-05 23.0 0.0 0.00011 22.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 CCF40635.1 - 0.001 18.9 0.0 0.0019 18.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 CCF40635.1 - 0.0019 18.6 0.0 0.0047 17.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain NDUF_B4 PF07225.7 CCF40636.1 - 0.00065 19.5 0.0 0.00069 19.4 0.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) AA_permease_2 PF13520.1 CCF40638.1 - 2.2e-30 105.5 18.1 2.2e-30 105.5 12.6 1.4 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF40638.1 - 6.9e-06 24.6 14.3 9.3e-06 24.2 9.9 1.1 1 0 0 1 1 1 1 Amino acid permease TctB PF07331.6 CCF40638.1 - 0.00092 18.8 1.4 0.00092 18.8 1.0 2.2 1 1 0 2 2 2 1 Tripartite tricarboxylate transporter TctB family Vpu PF00558.14 CCF40638.1 - 3.1 7.4 6.7 0.25 10.9 1.3 1.7 2 0 0 2 2 2 0 Vpu protein CN_hydrolase PF00795.17 CCF40640.1 - 1.4e-32 112.5 0.0 2.1e-32 111.9 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase FMN_red PF03358.10 CCF40644.1 - 0.0016 17.9 0.0 0.0022 17.5 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase ApbA PF02558.11 CCF40646.1 - 5.5e-07 29.1 0.0 5.8e-07 29.0 0.0 1.0 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ThiF PF00899.16 CCF40646.1 - 0.013 15.3 0.4 0.016 14.9 0.3 1.2 1 0 0 1 1 1 0 ThiF family Shikimate_DH PF01488.15 CCF40646.1 - 0.049 13.7 0.2 0.064 13.3 0.1 1.1 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 CCF40646.1 - 0.077 12.9 0.0 0.086 12.8 0.0 1.0 1 0 0 1 1 1 0 NADH(P)-binding FAD_binding_3 PF01494.14 CCF40646.1 - 0.087 11.8 0.1 0.087 11.8 0.1 1.0 1 0 0 1 1 1 0 FAD binding domain DUF2470 PF10615.4 CCF40647.1 - 9.9e-20 70.5 0.0 1.4e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) DUF1953 PF09196.5 CCF40647.1 - 0.052 13.2 0.0 0.086 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1953) Glyco_hydro_12 PF01670.11 CCF40648.1 - 7.4e-20 71.3 0.6 7.4e-20 71.3 0.4 1.8 1 1 1 2 2 2 1 Glycosyl hydrolase family 12 PPV_E2_C PF00511.12 CCF40648.1 - 4 7.4 7.3 6.3 6.8 1.6 2.4 1 1 1 2 2 2 0 E2 (early) protein, C terminal Methyltransf_23 PF13489.1 CCF40649.1 - 1.6e-19 70.1 0.0 2.3e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF40649.1 - 1.7e-09 38.2 0.0 2.3e-08 34.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF40649.1 - 8.7e-09 35.1 0.0 6.5e-08 32.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF40649.1 - 2e-07 31.3 0.0 3.5e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF40649.1 - 5.1e-06 26.8 0.0 4.8e-05 23.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF40649.1 - 0.00017 20.9 0.0 0.0013 18.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.1 CCF40649.1 - 0.00057 20.2 0.0 0.0018 18.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF40649.1 - 0.002 17.2 0.1 0.011 14.7 0.0 2.1 2 1 1 3 3 3 1 Putative methyltransferase PrmA PF06325.8 CCF40649.1 - 0.002 17.2 0.0 0.0032 16.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 CCF40649.1 - 0.0042 17.1 0.0 0.047 13.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 CCF40649.1 - 0.012 15.6 0.0 0.06 13.3 0.0 2.0 2 1 0 2 2 2 0 FtsJ-like methyltransferase Ubie_methyltran PF01209.13 CCF40649.1 - 0.019 14.0 0.0 0.23 10.5 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.4 CCF40649.1 - 0.033 13.6 0.0 0.056 12.8 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_23 PF13489.1 CCF40651.1 - 3e-21 75.8 0.0 4.8e-21 75.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF40651.1 - 1.1e-10 41.8 0.0 1.8e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF40651.1 - 1.2e-10 41.1 0.0 7.4e-10 38.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF40651.1 - 3.8e-08 33.8 0.1 3.6e-07 30.7 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF40651.1 - 7.7e-08 32.7 0.0 5.5e-07 29.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF40651.1 - 5.5e-07 29.8 0.0 1.3e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 CCF40651.1 - 0.00075 18.7 0.0 0.0013 17.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 CCF40651.1 - 0.0012 18.2 0.0 0.0027 17.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain GidB PF02527.10 CCF40651.1 - 0.057 12.5 0.0 0.28 10.3 0.0 1.9 1 1 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_26 PF13659.1 CCF40651.1 - 0.062 13.3 0.0 0.24 11.4 0.0 2.0 2 1 0 2 2 2 0 Methyltransferase domain FtsJ PF01728.14 CCF40651.1 - 0.08 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Ubie_methyltran PF01209.13 CCF40651.1 - 0.093 11.8 0.0 0.64 9.0 0.0 2.0 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family PCMT PF01135.14 CCF40651.1 - 0.12 11.8 0.0 0.27 10.7 0.0 1.6 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF865 PF05906.6 CCF40654.1 - 0.13 11.8 0.3 0.29 10.7 0.2 1.6 1 0 0 1 1 1 0 Herpesvirus-7 repeat of unknown function (DUF865) UME PF08064.8 CCF40655.1 - 5.4e-30 103.4 0.1 1.3e-28 99.0 0.0 3.2 3 0 0 3 3 3 1 UME (NUC010) domain MFS_1 PF07690.11 CCF40656.1 - 5.2e-34 117.5 26.5 5.2e-34 117.5 18.3 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Methyltrans_SAM PF10672.4 CCF40656.1 - 0.1 11.3 0.0 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase DUF3390 PF11870.3 CCF40656.1 - 0.17 11.8 0.0 0.36 10.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3390) FMN_dh PF01070.13 CCF40657.1 - 2.6e-111 371.9 0.0 6.8e-111 370.5 0.0 1.6 1 1 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 CCF40657.1 - 1e-18 66.9 0.0 2.2e-18 65.8 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.12 CCF40657.1 - 2.7e-07 29.8 0.0 3.9e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.10 CCF40657.1 - 7.2e-06 25.3 0.3 1.1e-05 24.7 0.2 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 CCF40657.1 - 8.6e-05 21.5 0.1 0.00013 20.9 0.1 1.3 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.9 CCF40657.1 - 0.0026 16.9 0.1 0.69 8.9 0.0 2.2 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG His_biosynth PF00977.16 CCF40657.1 - 0.042 13.1 0.1 0.61 9.3 0.0 2.3 3 0 0 3 3 3 0 Histidine biosynthesis protein DHO_dh PF01180.16 CCF40657.1 - 0.16 10.9 0.1 0.33 9.8 0.0 1.4 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase Trp_DMAT PF11991.3 CCF40659.1 - 6.7e-48 163.7 0.0 7.3e-48 163.6 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase FAD_binding_4 PF01565.18 CCF40660.1 - 2.5e-27 95.0 0.1 4.9e-27 94.0 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain mRNA_triPase PF02940.10 CCF40661.1 - 5.2e-53 179.9 0.0 7.4e-53 179.4 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Xan_ur_permease PF00860.15 CCF40662.1 - 1.3e-30 106.2 9.8 1.9e-30 105.6 6.8 1.2 1 0 0 1 1 1 1 Permease family Pec_lyase_C PF00544.14 CCF40663.1 - 5.5e-18 65.1 5.9 1.2e-17 64.0 4.1 1.6 1 1 0 1 1 1 1 Pectate lyase TipAS PF07739.8 CCF40664.1 - 0.032 14.5 0.1 0.042 14.1 0.1 1.2 1 0 0 1 1 1 0 TipAS antibiotic-recognition domain AlaDh_PNT_C PF01262.16 CCF40667.1 - 1.1e-14 54.3 0.0 1.7e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Head_binding PF09008.5 CCF40667.1 - 0.13 12.2 0.1 0.2 11.7 0.1 1.2 1 0 0 1 1 1 0 Head binding Cmc1 PF08583.5 CCF40668.1 - 1.1e-17 63.5 0.9 1.1e-17 63.5 0.6 2.0 3 0 0 3 3 3 1 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.8 CCF40668.1 - 0.0093 15.8 0.1 0.17 11.8 0.1 2.2 1 1 1 2 2 2 2 CHCH domain DUF3128 PF11326.3 CCF40668.1 - 0.15 12.2 6.8 0.24 11.5 1.2 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF3128) fn3 PF00041.16 CCF40669.1 - 3.2e-08 33.5 0.0 9.6e-08 32.0 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III domain UDPGP PF01704.13 CCF40670.1 - 6.5e-54 183.0 0.0 8.6e-54 182.6 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.2 CCF40670.1 - 0.067 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 MobA-like NTP transferase domain PM0188 PF11477.3 CCF40670.1 - 0.15 10.8 0.1 0.24 10.1 0.0 1.2 1 0 0 1 1 1 0 Sialyltransferase PMO188 MFS_1 PF07690.11 CCF40671.1 - 1.7e-34 119.0 38.8 1.7e-34 119.0 26.9 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily ADH_zinc_N PF00107.21 CCF40672.1 - 4.3e-11 42.4 0.1 1e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF40672.1 - 0.0001 22.0 0.1 0.00026 20.6 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Exo70 PF03081.10 CCF40674.1 - 2.5e-11 43.0 0.2 1.1e-10 40.8 0.0 2.0 2 1 0 2 2 2 1 Exo70 exocyst complex subunit Retro_M PF02813.9 CCF40674.1 - 0.0078 16.3 0.4 1.1 9.4 0.0 3.2 3 0 0 3 3 3 1 Retroviral M domain Baculo_PEP_C PF04513.7 CCF40674.1 - 0.044 13.6 5.1 14 5.5 0.0 3.6 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus GAS PF13851.1 CCF40674.1 - 0.099 11.8 2.1 4.1 6.5 0.1 2.6 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding CENP-Q PF13094.1 CCF40674.1 - 0.17 11.9 2.7 0.97 9.4 1.3 2.4 2 1 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Aminotran_3 PF00202.16 CCF40675.1 - 6.6e-81 271.7 0.0 8.5e-81 271.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 CCF40675.1 - 0.026 13.4 0.0 0.09 11.7 0.0 1.8 2 0 0 2 2 2 0 Aminotransferase class I and II PHY PF00360.15 CCF40676.1 - 3e-28 98.1 0.0 6.8e-28 97.0 0.0 1.6 1 0 0 1 1 1 1 Phytochrome region HATPase_c PF02518.21 CCF40676.1 - 1e-18 67.0 0.3 2e-18 66.0 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF PF01590.21 CCF40676.1 - 7.5e-17 61.8 0.0 1.9e-16 60.5 0.0 1.7 1 0 0 1 1 1 1 GAF domain HisKA PF00512.20 CCF40676.1 - 4.7e-13 48.9 0.5 1.8e-12 47.0 0.3 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_2 PF08446.6 CCF40676.1 - 1.7e-08 34.8 0.0 5.3e-08 33.3 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.1 CCF40676.1 - 0.035 14.4 0.0 0.096 13.0 0.0 1.7 1 0 0 1 1 1 0 PAS domain HATPase_c_3 PF13589.1 CCF40676.1 - 0.087 12.4 0.1 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cornifin PF02389.10 CCF40676.1 - 0.18 11.5 5.8 0.031 14.0 1.1 1.8 2 0 0 2 2 2 0 Cornifin (SPRR) family ECH PF00378.15 CCF40677.1 - 2.3e-40 138.2 0.0 3.6e-40 137.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family ECH_C PF13766.1 CCF40677.1 - 0.0068 16.5 0.1 0.012 15.7 0.1 1.4 1 0 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region Tbf5 PF06331.7 CCF40678.1 - 3.4e-28 97.2 0.6 3.7e-28 97.0 0.4 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 TENA_THI-4 PF03070.11 CCF40679.1 - 7.1e-44 150.0 0.1 4.7e-43 147.3 0.1 1.8 1 1 0 1 1 1 1 TENA/THI-4/PQQC family DEAD PF00270.24 CCF40681.1 - 8.6e-46 155.5 0.0 9.8e-45 152.0 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 CCF40681.1 - 0.00012 21.9 0.0 0.00039 20.3 0.0 1.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Glyoxalase_3 PF13468.1 CCF40681.1 - 0.078 12.8 0.1 0.18 11.6 0.0 1.6 2 0 0 2 2 2 0 Glyoxalase-like domain AAA_22 PF13401.1 CCF40681.1 - 0.22 11.6 1.6 4.5 7.4 0.2 2.8 1 1 1 2 2 2 0 AAA domain AAA PF00004.24 CCF40681.1 - 0.34 11.1 1.3 3.5 7.8 0.1 2.5 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Zn_clus PF00172.13 CCF40682.1 - 0.0027 17.5 10.9 0.0036 17.1 7.5 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RTBV_P12 PF06361.6 CCF40682.1 - 0.064 13.4 0.7 0.09 13.0 0.2 1.5 2 0 0 2 2 2 0 Rice tungro bacilliform virus P12 protein Aminotran_1_2 PF00155.16 CCF40683.1 - 3.8e-81 272.8 0.0 4.8e-81 272.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 CCF40683.1 - 3.1e-05 22.4 0.0 4.9e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 CCF40683.1 - 7e-05 21.7 0.1 0.00019 20.3 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class-V DUF3405 PF11885.3 CCF40683.1 - 0.12 10.6 0.0 0.17 10.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) MFS_1 PF07690.11 CCF40684.1 - 5.5e-13 48.3 31.2 5.5e-13 48.3 21.6 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 CCF40684.1 - 0.00012 21.6 5.4 0.00036 20.0 3.7 1.8 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 Tyrosinase PF00264.15 CCF40685.1 - 1e-35 123.9 0.0 1.2e-35 123.6 0.0 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase GPI-anchored PF10342.4 CCF40686.1 - 5.5e-20 71.6 5.1 5.5e-20 71.6 3.5 3.0 2 1 1 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Hex_IIIa PF02455.11 CCF40686.1 - 0.058 12.0 2.8 0.076 11.6 1.9 1.1 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) Srg PF02118.16 CCF40686.1 - 0.059 12.8 2.5 0.08 12.3 1.7 1.2 1 0 0 1 1 1 0 Srg family chemoreceptor Rifin_STEVOR PF02009.11 CCF40686.1 - 0.29 10.7 4.7 0.37 10.3 3.2 1.2 1 0 0 1 1 1 0 Rifin/stevor family Methyltransf_16 PF10294.4 CCF40687.1 - 0.088 12.2 0.0 0.33 10.3 0.0 1.8 2 0 0 2 2 2 0 Putative methyltransferase Pyr_redox_3 PF13738.1 CCF40688.1 - 4.2e-19 69.4 0.0 1e-18 68.1 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF40688.1 - 8.3e-08 32.1 0.0 2.3e-07 30.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.14 CCF40688.1 - 2.5e-06 25.9 0.1 2.1e-05 22.9 0.1 2.3 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.1 CCF40688.1 - 0.00033 19.6 0.0 0.081 11.8 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 CCF40688.1 - 0.00098 18.9 0.1 0.028 14.2 0.0 2.8 3 0 0 3 3 3 1 FAD-NAD(P)-binding Peptidase_M18 PF02127.10 CCF40689.1 - 1.7e-120 402.4 0.0 1.9e-120 402.2 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) HET PF06985.6 CCF40692.1 - 8e-26 90.8 0.0 1.3e-25 90.1 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) p450 PF00067.17 CCF40693.1 - 3.3e-14 52.2 0.0 5e-13 48.3 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 DUF1275 PF06912.6 CCF40695.1 - 1.6e-38 131.9 15.5 2.1e-38 131.6 10.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) adh_short PF00106.20 CCF40696.1 - 8e-08 32.3 0.4 1.3e-07 31.6 0.3 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF40696.1 - 0.016 14.9 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF40696.1 - 0.081 12.5 0.1 0.4 10.3 0.1 2.1 1 1 0 1 1 1 0 KR domain Sds3 PF08598.6 CCF40697.1 - 2.1e-43 148.2 5.1 2.8e-43 147.8 3.6 1.1 1 0 0 1 1 1 1 Sds3-like Raptor_N PF14538.1 CCF40697.1 - 0.11 12.2 0.1 0.2 11.4 0.1 1.4 1 0 0 1 1 1 0 Raptor N-terminal CASPase like domain PMC2NT PF08066.7 CCF40697.1 - 0.19 12.0 1.5 1 9.7 0.1 2.6 1 1 1 3 3 3 0 PMC2NT (NUC016) domain DUF3812 PF12757.2 CCF40697.1 - 0.24 11.3 5.0 0.12 12.3 1.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3812) DUF904 PF06005.7 CCF40697.1 - 6.2 7.1 10.3 10 6.5 0.1 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF904) COG5 PF10392.4 CCF40698.1 - 1.5e-05 24.9 2.0 0.00031 20.7 0.1 2.9 3 0 0 3 3 3 1 Golgi transport complex subunit 5 IATP PF04568.7 CCF40698.1 - 0.024 14.6 3.1 0.033 14.2 0.0 2.6 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP COG7 PF10191.4 CCF40698.1 - 0.025 12.5 0.0 0.065 11.1 0.0 1.6 2 0 0 2 2 2 0 Golgi complex component 7 (COG7) DUF241 PF03087.9 CCF40698.1 - 0.036 13.5 0.0 0.072 12.5 0.0 1.4 1 0 0 1 1 1 0 Arabidopsis protein of unknown function PNMA PF14893.1 CCF40698.1 - 0.053 12.5 0.2 0.079 11.9 0.2 1.2 1 0 0 1 1 1 0 PNMA Ku_PK_bind PF08785.6 CCF40698.1 - 0.15 11.9 0.4 1.8 8.4 0.2 2.3 2 0 0 2 2 2 0 Ku C terminal domain like Spore_II_R PF09551.5 CCF40698.1 - 0.17 11.9 1.0 0.31 11.0 0.7 1.4 1 0 0 1 1 1 0 Stage II sporulation protein R (spore_II_R) Atg14 PF10186.4 CCF40698.1 - 0.17 10.7 1.9 0.15 10.9 0.3 1.6 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 MbeB_N PF04837.7 CCF40698.1 - 1.5 9.0 4.3 2 8.5 0.4 2.7 2 0 0 2 2 2 0 MbeB-like, N-term conserved region DUF4404 PF14357.1 CCF40698.1 - 9.9 6.6 7.7 1.6 9.2 1.4 2.5 2 2 0 2 2 2 0 Domain of unknown function (DUF4404) SLAC1 PF03595.12 CCF40699.1 - 4.3e-12 45.3 8.5 4.7e-12 45.2 5.9 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Corona_M PF01635.13 CCF40699.1 - 0.0048 15.8 6.6 0.023 13.6 1.2 2.0 1 1 1 2 2 2 2 Coronavirus M matrix/glycoprotein Choline_transpo PF04515.7 CCF40699.1 - 0.032 12.9 1.8 0.036 12.8 1.3 1.1 1 0 0 1 1 1 0 Plasma-membrane choline transporter DUF805 PF05656.9 CCF40699.1 - 0.88 9.4 3.6 0.96 9.2 2.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF805) ABC2_membrane_3 PF12698.2 CCF40699.1 - 0.94 8.4 4.0 1.1 8.2 2.8 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein PI3Ka PF00613.15 CCF40701.1 - 2.4e-59 199.6 1.2 3.8e-59 198.9 0.8 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.22 CCF40701.1 - 8.7e-44 149.7 0.0 2.1e-42 145.2 0.0 2.7 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.19 CCF40701.1 - 0.028 14.2 0.0 0.051 13.3 0.0 1.4 1 0 0 1 1 1 0 Phosphoinositide 3-kinase C2 AMP-binding PF00501.23 CCF40703.1 - 2.6e-67 227.0 0.0 3.8e-67 226.4 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.15 CCF40703.1 - 7.2e-52 176.1 0.0 1e-51 175.6 0.0 1.2 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.20 CCF40703.1 - 4.1e-09 36.5 0.4 9.5e-09 35.3 0.3 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site HxxPF_rpt PF13745.1 CCF40703.1 - 7.8e-08 32.5 0.0 2.1e-07 31.1 0.0 1.8 1 0 0 1 1 1 1 HxxPF-repeated domain ENTH PF01417.15 CCF40704.1 - 6.4e-47 158.5 0.1 9e-47 158.0 0.1 1.2 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.11 CCF40704.1 - 0.00021 20.0 0.0 0.00029 19.6 0.0 1.1 1 0 0 1 1 1 1 ANTH domain PBP1_TM PF14812.1 CCF40705.1 - 0.27 11.5 2.2 0.38 11.1 1.5 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Brix PF04427.13 CCF40706.1 - 4.2e-49 166.8 0.3 5.5e-49 166.4 0.2 1.2 1 0 0 1 1 1 1 Brix domain SNARE PF05739.14 CCF40707.1 - 4.9e-12 45.3 4.4 4.9e-12 45.3 3.0 2.3 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 CCF40707.1 - 2.5e-09 37.1 6.1 2.5e-09 37.1 4.2 2.6 2 0 0 2 2 2 1 Syntaxin Use1 PF09753.4 CCF40707.1 - 0.01 15.2 10.8 0.016 14.6 7.5 1.3 1 1 0 1 1 1 0 Membrane fusion protein Use1 DUF3094 PF11293.3 CCF40707.1 - 0.013 14.9 0.1 0.039 13.4 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3094) Dispanin PF04505.7 CCF40707.1 - 0.017 14.6 0.0 0.038 13.5 0.0 1.5 1 0 0 1 1 1 0 Interferon-induced transmembrane protein Prominin PF05478.6 CCF40707.1 - 0.029 11.9 8.0 0.064 10.8 5.5 1.6 1 1 0 1 1 1 0 Prominin DUF2077 PF09850.4 CCF40707.1 - 0.092 12.1 0.2 0.092 12.1 0.1 2.6 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2077) Syntaxin_2 PF14523.1 CCF40707.1 - 0.11 12.5 16.0 0.12 12.3 5.3 2.7 2 1 0 2 2 2 0 Syntaxin-like protein HeLo PF14479.1 CCF40707.1 - 0.18 11.4 12.3 0.026 14.2 2.2 2.4 1 1 1 2 2 2 0 Prion-inhibition and propagation DUF4094 PF13334.1 CCF40707.1 - 0.2 12.0 7.2 0.99 9.8 0.0 3.5 2 2 2 4 4 4 0 Domain of unknown function (DUF4094) Fib_alpha PF08702.5 CCF40707.1 - 0.23 11.5 13.1 0.27 11.3 2.5 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family FUSC PF04632.7 CCF40707.1 - 0.3 9.4 15.6 0.077 11.4 3.3 2.1 1 1 0 2 2 2 0 Fusaric acid resistance protein family DUF4404 PF14357.1 CCF40707.1 - 0.84 10.0 14.3 0.48 10.8 0.2 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) SQS_PSY PF00494.14 CCF40707.1 - 0.92 8.7 7.2 0.67 9.2 0.5 2.1 1 1 1 2 2 2 0 Squalene/phytoene synthase Peptidase_C6 PF00851.13 CCF40707.1 - 1.3 7.5 10.7 0.081 11.5 1.9 2.0 1 1 1 2 2 2 0 Helper component proteinase Tweety PF04906.8 CCF40707.1 - 3.1 6.0 9.0 0.26 9.6 1.7 2.2 1 1 2 3 3 3 0 Tweety DUF3708 PF12501.3 CCF40707.1 - 3.9 7.2 11.6 0.62 9.8 1.5 2.6 1 1 1 3 3 3 0 Phosphate ATP-binding cassette transporter Allexi_40kDa PF05549.6 CCF40707.1 - 4.4 6.5 9.4 1.2 8.3 1.7 2.2 2 0 0 2 2 2 0 Allexivirus 40kDa protein TPR_11 PF13414.1 CCF40708.1 - 4.2e-54 180.0 18.3 3.5e-14 52.1 1.1 7.0 4 2 3 7 7 7 7 TPR repeat TPR_1 PF00515.23 CCF40708.1 - 5.7e-47 155.4 19.7 2.9e-06 26.6 0.0 11.5 11 0 0 11 11 11 10 Tetratricopeptide repeat TPR_2 PF07719.12 CCF40708.1 - 8.4e-43 140.8 15.2 9.4e-05 22.0 0.0 11.4 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_16 PF13432.1 CCF40708.1 - 1.1e-28 99.2 0.9 0.00039 20.9 0.1 6.9 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.1 CCF40708.1 - 7.9e-28 96.2 15.8 6.1e-07 29.2 0.0 7.5 2 2 6 8 8 8 8 Tetratricopeptide repeat TPR_17 PF13431.1 CCF40708.1 - 5.5e-26 88.5 9.5 6.5e-05 22.8 0.0 9.4 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_8 PF13181.1 CCF40708.1 - 8.7e-18 62.7 16.1 0.0096 15.6 0.1 11.0 9 2 2 11 11 11 4 Tetratricopeptide repeat TPR_19 PF14559.1 CCF40708.1 - 1.9e-14 53.7 12.4 9.4e-06 25.8 0.4 7.0 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.1 CCF40708.1 - 9.5e-14 50.6 17.2 0.041 14.5 0.4 9.9 4 3 6 11 11 10 2 Tetratricopeptide repeat TPR_7 PF13176.1 CCF40708.1 - 9.5e-13 46.9 13.8 0.048 13.4 0.1 9.0 9 0 0 9 9 9 3 Tetratricopeptide repeat Apc3 PF12895.2 CCF40708.1 - 3.7e-11 43.0 11.0 0.015 15.3 0.1 5.6 2 1 3 5 5 5 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 CCF40708.1 - 6.5e-11 41.9 5.1 0.00073 19.3 0.0 6.4 3 2 5 8 8 8 2 Tetratricopeptide repeat SHNi-TPR PF10516.4 CCF40708.1 - 1e-06 27.8 4.1 0.23 10.7 0.0 5.3 6 0 0 6 6 6 2 SHNi-TPR TPR_15 PF13429.1 CCF40708.1 - 1.1e-06 27.8 3.2 0.39 9.7 0.2 5.1 2 1 3 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.1 CCF40708.1 - 2.1e-06 27.8 14.8 10 6.8 0.0 8.6 8 0 0 8 8 8 0 Tetratricopeptide repeat MAS20 PF02064.10 CCF40708.1 - 1.2e-05 25.1 3.2 0.082 12.8 0.0 4.3 4 2 0 5 5 5 1 MAS20 protein import receptor TPR_10 PF13374.1 CCF40708.1 - 0.061 13.2 13.6 4.1 7.4 0.3 6.1 7 0 0 7 7 5 0 Tetratricopeptide repeat Sel1 PF08238.7 CCF40708.1 - 0.061 13.9 9.1 6.8 7.4 0.1 4.4 4 0 0 4 4 3 0 Sel1 repeat PAPA-1 PF04795.7 CCF40708.1 - 1.9 9.2 9.3 12 6.6 0.1 2.5 2 0 0 2 2 2 0 PAPA-1-like conserved region TPR_3 PF07720.7 CCF40708.1 - 6.6 6.6 17.8 0.82 9.5 0.3 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat Aminotran_4 PF01063.14 CCF40709.1 - 5e-15 55.6 0.0 6.8e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV zf-C4pol PF14260.1 CCF40710.1 - 2e-05 24.5 0.1 3.4e-05 23.7 0.1 1.3 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DUF2404 PF10296.4 CCF40711.1 - 2.5e-31 107.6 0.0 1e-30 105.7 0.0 2.0 2 0 0 2 2 2 1 Putative integral membrane protein conserved region (DUF2404) ADH_N PF08240.7 CCF40713.1 - 5.9e-24 83.9 1.4 1.1e-23 83.0 1.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF40713.1 - 1.9e-19 69.5 0.2 3.6e-19 68.6 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF2493 PF10686.4 CCF40713.1 - 0.0052 16.3 0.2 0.01 15.3 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2493) MFS_1 PF07690.11 CCF40714.1 - 1.2e-48 165.6 59.3 4.5e-47 160.4 40.7 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF40714.1 - 8.4e-19 67.1 14.1 1.2e-18 66.6 9.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 CCF40714.1 - 9.2e-13 47.5 12.0 9.2e-13 47.5 8.3 3.0 2 1 1 3 3 3 1 Sugar (and other) transporter UPF0233 PF06781.7 CCF40714.1 - 0.082 12.5 0.1 0.082 12.5 0.1 3.2 3 1 1 4 4 4 0 Uncharacterised protein family (UPF0233) SSP160 PF06933.6 CCF40715.1 - 0.094 10.6 3.9 0.11 10.4 2.7 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 NPCBM_assoc PF10633.4 CCF40717.1 - 0.068 13.2 0.0 0.078 13.0 0.0 1.1 1 0 0 1 1 1 0 NPCBM-associated, NEW3 domain of alpha-galactosidase Peptidase_M28 PF04389.12 CCF40719.1 - 1.4e-31 109.6 0.0 2.3e-31 108.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 CCF40719.1 - 0.0065 15.9 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Tcp11 PF05794.8 CCF40720.1 - 1.6e-46 158.9 0.0 4.8e-46 157.3 0.0 1.7 2 0 0 2 2 2 1 T-complex protein 11 DUF2955 PF11168.3 CCF40722.1 - 0.011 15.4 2.1 0.02 14.5 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2955) Fungal_trans_2 PF11951.3 CCF40723.1 - 1.8e-12 46.5 3.6 1.5e-08 33.6 0.9 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain F-box-like PF12937.2 CCF40724.1 - 7.5e-05 22.3 0.2 0.00024 20.7 0.1 2.0 2 0 0 2 2 2 1 F-box-like DUF905 PF06006.7 CCF40724.1 - 0.049 13.0 0.6 6.7 6.1 0.0 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF905) MFS_1 PF07690.11 CCF40726.1 - 1.2e-08 34.0 30.1 1.2e-08 34.0 20.9 2.2 1 1 0 2 2 2 1 Major Facilitator Superfamily DNA_pol_E_B PF04042.11 CCF40727.1 - 1.6e-53 181.0 0.0 2.3e-53 180.5 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Elong-fact-P_C PF09285.6 CCF40727.1 - 0.14 11.5 0.2 0.9 8.9 0.0 2.2 2 0 0 2 2 2 0 Elongation factor P, C-terminal MFS_1 PF07690.11 CCF40729.1 - 1e-13 50.7 17.8 1.2e-13 50.5 12.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily OppC_N PF12911.2 CCF40729.1 - 0.011 15.0 0.1 0.077 12.3 0.0 2.3 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C MFS_1 PF07690.11 CCF40730.1 - 7.9e-05 21.5 0.1 0.00014 20.6 0.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily 2-Hacid_dh_C PF02826.14 CCF40731.1 - 9.9e-53 177.9 0.0 1.4e-52 177.4 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 CCF40731.1 - 3.8e-23 81.4 0.1 5.1e-23 81.0 0.1 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 CCF40731.1 - 0.0011 18.7 0.0 0.0024 17.7 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.16 CCF40731.1 - 0.0022 17.8 0.0 0.0043 16.9 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_Gly3P_dh_N PF01210.18 CCF40731.1 - 0.0058 16.3 0.2 0.016 14.9 0.1 1.9 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DUF1348 PF07080.6 CCF40732.1 - 1.7e-52 177.0 6.5 2e-52 176.7 4.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1348) SnoaL_2 PF12680.2 CCF40732.1 - 0.0065 16.8 0.6 0.01 16.2 0.4 1.3 1 0 0 1 1 1 1 SnoaL-like domain STE3 PF02076.10 CCF40733.1 - 1.2e-05 24.5 0.5 1.5e-05 24.2 0.4 1.1 1 0 0 1 1 1 1 Pheromone A receptor DUF3328 PF11807.3 CCF40735.1 - 1.9e-18 66.9 0.4 2.6e-18 66.5 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Propeptide_C1 PF08127.8 CCF40735.1 - 0.052 13.1 0.1 0.21 11.2 0.0 2.0 2 0 0 2 2 2 0 Peptidase family C1 propeptide zf-C2H2_4 PF13894.1 CCF40736.1 - 5e-05 23.3 5.2 0.041 14.2 0.1 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF40736.1 - 0.021 15.1 4.3 0.69 10.3 0.1 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type TEX13 PF15186.1 CCF40738.1 - 0.63 9.6 3.4 1.1 8.8 2.2 1.4 1 1 0 1 1 1 0 Testis-expressed sequence 13 protein family Oxysterol_BP PF01237.13 CCF40739.1 - 0.048 12.1 0.1 0.048 12.1 0.0 2.3 2 1 0 2 2 2 0 Oxysterol-binding protein Ribosom_S12_S23 PF00164.20 CCF40741.1 - 6e-22 77.3 0.2 7.2e-22 77.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Inhibitor_I9 PF05922.11 CCF40743.1 - 0.12 12.9 0.0 0.14 12.7 0.0 1.2 1 0 0 1 1 1 0 Peptidase inhibitor I9 Aldedh PF00171.17 CCF40744.1 - 5.4e-107 357.9 0.0 6.8e-107 357.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PhoD PF09423.5 CCF40745.1 - 1.3e-09 37.1 0.3 2.3e-07 29.7 0.1 2.3 2 0 0 2 2 2 2 PhoD-like phosphatase RNB PF00773.14 CCF40746.1 - 1.4e-94 317.0 0.0 1.9e-94 316.5 0.0 1.1 1 0 0 1 1 1 1 RNB domain Fungal_trans PF04082.13 CCF40747.1 - 4.6e-14 51.9 0.0 9.3e-14 50.9 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF40747.1 - 2.6e-07 30.4 12.4 4.6e-07 29.6 8.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pex14_N PF04695.8 CCF40747.1 - 0.47 10.5 5.4 1 9.4 3.7 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Mif2_N PF15624.1 CCF40747.1 - 1.6 9.3 6.9 3 8.4 4.8 1.5 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Abhydrolase_6 PF12697.2 CCF40748.1 - 3.5e-20 72.8 0.2 5.4e-20 72.2 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF40748.1 - 1.3e-14 54.3 0.1 1.3e-09 37.9 0.1 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF40748.1 - 5.6e-08 32.6 0.4 8.6e-08 32.0 0.3 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CCF40748.1 - 2.1e-07 30.6 0.7 3.4e-07 30.0 0.5 1.4 1 0 0 1 1 1 1 Putative lysophospholipase CSTF2_hinge PF14327.1 CCF40751.1 - 3e-26 91.3 2.9 5.7e-26 90.4 2.0 1.5 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 Fungal_trans PF04082.13 CCF40751.1 - 1.3e-24 86.4 0.0 2.2e-24 85.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain CSTF_C PF14304.1 CCF40751.1 - 1.4e-06 27.4 3.6 1.4e-06 27.4 2.5 3.0 3 0 0 3 3 3 1 Transcription termination and cleavage factor C-terminal Fungal_trans PF04082.13 CCF40752.1 - 8.5e-19 67.4 0.0 1.4e-18 66.6 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF40752.1 - 6.9e-08 32.2 7.7 1.3e-07 31.4 5.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cellulase PF00150.13 CCF40753.1 - 1.3e-06 27.8 0.0 5.6e-06 25.7 0.0 1.8 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DEAD PF00270.24 CCF40754.1 - 2.5e-35 121.4 0.0 7.1e-35 119.9 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF40754.1 - 8.4e-20 70.4 0.0 2.1e-19 69.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 CCF40754.1 - 7.2e-19 67.0 0.0 1.4e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Spore_coat_CotO PF14153.1 CCF40754.1 - 5.6 6.3 13.1 9.4 5.6 9.1 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Zn_clus PF00172.13 CCF40755.1 - 1.2e-08 34.7 10.2 1.9e-08 34.0 7.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF40755.1 - 5.5e-05 22.1 0.0 8e-05 21.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-Mss51 PF13824.1 CCF40756.1 - 6.5e-07 29.1 2.2 1.3e-06 28.1 1.5 1.6 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 PXA PF02194.10 CCF40757.1 - 3.1e-41 140.9 0.7 5.5e-41 140.1 0.4 1.4 2 0 0 2 2 2 1 PXA domain Cutinase PF01083.17 CCF40758.1 - 2.7e-47 160.7 2.8 3.4e-47 160.4 2.0 1.1 1 0 0 1 1 1 1 Cutinase DUF2974 PF11187.3 CCF40758.1 - 0.016 14.5 0.1 0.031 13.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) PE-PPE PF08237.6 CCF40758.1 - 0.051 12.9 0.1 0.068 12.5 0.1 1.2 1 0 0 1 1 1 0 PE-PPE domain Thioesterase PF00975.15 CCF40758.1 - 0.054 13.7 0.0 0.075 13.2 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain Lipase_3 PF01764.20 CCF40758.1 - 0.063 12.8 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Aminotran_3 PF00202.16 CCF40759.1 - 7.8e-98 327.4 0.0 1e-97 327.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 CCF40759.1 - 2.9e-05 23.2 0.0 5.7e-05 22.2 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class I and II HET PF06985.6 CCF40760.1 - 8.8e-38 129.6 0.4 1.6e-37 128.7 0.3 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Abhydrolase_3 PF07859.8 CCF40761.1 - 7.6e-35 120.3 0.0 5.3e-25 88.2 0.0 2.6 3 0 0 3 3 3 2 alpha/beta hydrolase fold Lipase_3 PF01764.20 CCF40761.1 - 0.11 12.0 0.0 0.28 10.7 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) DUF2424 PF10340.4 CCF40761.1 - 0.13 10.9 0.0 0.19 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2424) Pkinase PF00069.20 CCF40763.1 - 8.7e-63 211.8 0.0 1.1e-62 211.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF40763.1 - 3.2e-25 88.6 0.0 4.2e-25 88.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF40763.1 - 1.4e-07 30.8 0.0 6e-07 28.7 0.0 1.8 1 1 0 2 2 2 1 Kinase-like APH PF01636.18 CCF40763.1 - 0.0047 16.6 0.0 0.018 14.8 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Zn_clus PF00172.13 CCF40764.1 - 1.5e-06 28.0 8.2 3e-06 27.0 5.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF40764.1 - 0.00076 18.4 0.2 0.0013 17.6 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF4570 PF15134.1 CCF40764.1 - 0.14 12.0 0.1 0.25 11.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) Aldo_ket_red PF00248.16 CCF40765.1 - 9.1e-46 155.9 0.0 1.1e-45 155.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PUF PF00806.14 CCF40767.1 - 2.4e-60 196.7 11.3 1.3e-07 30.6 0.0 8.2 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat TylF PF05711.6 CCF40767.1 - 0.017 14.2 0.1 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 Macrocin-O-methyltransferase (TylF) DIOX_N PF14226.1 CCF40769.1 - 1.8e-18 67.1 0.0 2.7e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 CCF40769.1 - 7.8e-15 54.9 0.0 1.6e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MKT1_C PF12246.3 CCF40770.1 - 3.4e-63 212.8 0.1 4.5e-63 212.4 0.0 1.2 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.3 CCF40770.1 - 1.7e-26 92.3 0.1 4.1e-26 91.1 0.0 1.7 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication UQ_con PF00179.21 CCF40772.1 - 2.7e-51 172.6 0.0 3.1e-51 172.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CCF40772.1 - 6.5e-05 22.6 0.0 7.8e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 CCF40772.1 - 0.0052 16.6 0.0 0.0057 16.5 0.0 1.2 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 CCF40772.1 - 0.022 14.4 0.0 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 UEV domain Alk_phosphatase PF00245.15 CCF40773.1 - 2.2e-67 227.5 0.0 6.3e-67 226.0 0.0 1.7 1 1 0 1 1 1 1 Alkaline phosphatase Sulfatase PF00884.18 CCF40773.1 - 1.3e-05 24.5 0.1 2.4e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.17 CCF40773.1 - 7.8e-05 22.1 0.1 0.0001 21.7 0.1 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.12 CCF40773.1 - 0.0046 15.4 0.1 0.0067 14.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) PglZ PF08665.7 CCF40773.1 - 0.17 11.4 0.1 0.3 10.7 0.1 1.3 1 0 0 1 1 1 0 PglZ domain MFS_1 PF07690.11 CCF40774.1 - 1.7e-27 96.1 31.6 2.4e-27 95.5 21.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily OPT PF03169.10 CCF40775.1 - 1.7e-119 400.0 40.4 1.9e-119 399.9 28.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Epimerase PF01370.16 CCF40776.1 - 0.031 13.7 0.0 0.047 13.1 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family KdpC PF02669.10 CCF40776.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 K+-transporting ATPase, c chain Glyco_hydro_18 PF00704.23 CCF40777.1 - 1.7e-88 297.3 2.4 2e-88 297.1 1.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 HTH_psq PF05225.11 CCF40778.1 - 1.1e-14 53.6 0.2 2.1e-14 52.7 0.2 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF40778.1 - 1.2e-12 47.4 0.5 4.9e-12 45.4 0.0 2.1 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.1 CCF40778.1 - 5.9e-05 22.5 0.0 0.00017 21.0 0.0 1.9 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 CCF40778.1 - 0.00026 20.9 0.1 0.00077 19.4 0.1 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_7 PF02796.10 CCF40778.1 - 0.00062 19.5 0.1 0.0012 18.7 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.1 CCF40778.1 - 0.002 17.6 0.1 0.0044 16.5 0.0 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_1 PF00126.22 CCF40778.1 - 0.035 13.8 0.9 0.071 12.8 0.6 1.5 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family SpoIIID PF12116.3 CCF40778.1 - 0.045 13.6 0.0 0.088 12.7 0.0 1.5 1 0 0 1 1 1 0 Stage III sporulation protein D CENP-B_N PF04218.8 CCF40778.1 - 0.054 12.9 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_8 PF02954.14 CCF40778.1 - 0.076 12.5 0.6 0.52 9.8 0.0 2.4 1 1 1 2 2 2 0 Bacterial regulatory protein, Fis family HTH_Tnp_1 PF01527.15 CCF40778.1 - 0.12 12.3 1.1 0.37 10.7 0.0 2.3 2 1 0 3 3 3 0 Transposase DUF4164 PF13747.1 CCF40778.1 - 0.14 12.3 0.2 0.26 11.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Fungal_trans PF04082.13 CCF40779.1 - 3.3e-09 35.9 0.1 7e-09 34.9 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Phosducin PF02114.11 CCF40781.1 - 4e-12 45.4 0.1 6.1e-12 44.8 0.1 1.2 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.15 CCF40781.1 - 0.012 15.3 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin LRR_4 PF12799.2 CCF40782.1 - 2.7e-11 42.8 0.3 2e-08 33.6 0.0 2.8 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CCF40782.1 - 5.7e-08 32.3 0.5 1.5e-07 31.0 0.2 1.8 2 0 0 2 2 2 1 Leucine rich repeat LRR_1 PF00560.28 CCF40782.1 - 5.4e-05 22.6 2.4 0.043 13.8 0.0 4.3 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_7 PF13504.1 CCF40782.1 - 0.013 15.6 9.3 0.035 14.2 0.1 4.0 4 0 0 4 4 4 0 Leucine rich repeat polyprenyl_synt PF00348.12 CCF40783.1 - 1.1e-56 191.5 0.0 1.5e-56 191.1 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase PAP1 PF08601.5 CCF40783.1 - 0.76 9.3 12.2 1.1 8.8 8.5 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Pex24p PF06398.6 CCF40784.1 - 7.1e-93 311.2 0.0 8.1e-93 311.0 0.0 1.0 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Reticulon PF02453.12 CCF40784.1 - 0.013 15.0 0.0 0.023 14.2 0.0 1.4 1 1 0 1 1 1 0 Reticulon DUF3292 PF11696.3 CCF40784.1 - 0.025 12.4 0.1 0.036 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF639 PF04842.7 CCF40784.1 - 0.12 10.4 0.1 0.18 9.9 0.1 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) TRAP_alpha PF03896.11 CCF40785.1 - 0.41 9.5 3.4 0.48 9.3 2.3 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit COPI_C PF06957.6 CCF40785.1 - 0.73 8.2 4.1 0.8 8.1 2.8 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus Thoc2 PF11732.3 CCF40787.1 - 3.5e-27 94.0 0.1 7.4e-27 92.9 0.1 1.6 1 0 0 1 1 1 1 Transcription- and export-related complex subunit RVT_1 PF00078.22 CCF40788.1 - 4.4e-32 111.1 0.0 7.3e-32 110.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.1 CCF40788.1 - 7.1e-21 74.0 0.2 1.7e-20 72.8 0.1 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 CCF40788.1 - 1.3e-11 44.9 0.5 3.4e-11 43.5 0.6 1.6 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family G_glu_transpept PF01019.16 CCF40789.1 - 5e-122 407.9 0.6 7.9e-65 219.2 0.4 2.0 1 1 1 2 2 2 2 Gamma-glutamyltranspeptidase DJ-1_PfpI PF01965.19 CCF40790.1 - 1.1e-18 67.0 0.0 2.8e-18 65.8 0.0 1.7 1 1 0 1 1 1 1 DJ-1/PfpI family DJ-1_PfpI_N PF13587.1 CCF40790.1 - 6.4e-05 22.4 0.0 0.00017 21.0 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of DJ-1_PfpI family DUF3602 PF12223.3 CCF40791.1 - 0.11 12.8 0.1 0.13 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3602) DUF1688 PF07958.6 CCF40792.1 - 2.6e-171 569.7 0.0 3.1e-171 569.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) PLDc PF00614.17 CCF40793.1 - 1.1e-07 31.4 0.1 2.5e-07 30.2 0.1 1.6 1 0 0 1 1 1 1 Phospholipase D Active site motif PLDc_2 PF13091.1 CCF40793.1 - 0.002 17.8 0.0 0.0082 15.8 0.0 1.9 2 0 0 2 2 2 1 PLD-like domain RNB PF00773.14 CCF40794.1 - 1.4e-44 152.7 0.0 2.2e-44 152.0 0.0 1.3 1 0 0 1 1 1 1 RNB domain PAP_assoc PF03828.14 CCF40795.1 - 1.7e-13 50.3 0.0 3.1e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase Peptidase_C57 PF03290.8 CCF40795.1 - 0.096 11.1 0.0 0.71 8.3 0.0 1.9 2 0 0 2 2 2 0 Vaccinia virus I7 processing peptidase Condensation PF00668.15 CCF40796.1 - 1.8e-37 128.8 0.0 2.6e-37 128.3 0.0 1.2 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.20 CCF40796.1 - 2.9e-06 27.4 0.1 7.1e-06 26.1 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site HxxPF_rpt PF13745.1 CCF40796.1 - 1.6e-05 25.1 0.0 0.00014 22.1 0.0 2.5 2 0 0 2 2 2 1 HxxPF-repeated domain SPOR PF05036.8 CCF40796.1 - 0.034 14.2 0.0 0.1 12.7 0.0 1.9 1 0 0 1 1 1 0 Sporulation related domain AA_permease_2 PF13520.1 CCF40797.1 - 2e-42 145.2 16.3 3.9e-42 144.2 11.3 1.4 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF40797.1 - 7.2e-08 31.2 22.5 3.5e-07 28.9 15.6 1.8 1 1 0 1 1 1 1 Amino acid permease DUF998 PF06197.8 CCF40797.1 - 0.11 11.8 5.3 0.02 14.2 1.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF998) DUF4632 PF15451.1 CCF40798.1 - 0.016 15.1 0.1 0.7 9.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4632) XPG_I_2 PF12813.2 CCF40798.1 - 0.13 11.7 0.0 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 XPG domain containing Rad50_zn_hook PF04423.9 CCF40799.1 - 0.00052 19.4 0.2 0.00084 18.7 0.1 1.4 1 0 0 1 1 1 1 Rad50 zinc hook motif Cys_rich_KTR PF14205.1 CCF40799.1 - 0.045 13.2 0.2 0.085 12.3 0.1 1.4 1 0 0 1 1 1 0 Cysteine-rich KTR zf-C2H2_4 PF13894.1 CCF40799.1 - 0.057 13.7 0.3 0.16 12.3 0.0 1.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-TFIIB PF13453.1 CCF40799.1 - 0.059 12.5 0.1 0.097 11.8 0.1 1.3 1 0 0 1 1 1 0 Transcription factor zinc-finger Luteo_Vpg PF01659.11 CCF40799.1 - 0.065 12.9 0.2 0.083 12.5 0.1 1.3 1 0 0 1 1 1 0 Luteovirus putative VPg genome linked protein zf-Di19 PF05605.7 CCF40799.1 - 0.11 12.6 0.2 0.46 10.6 0.1 1.8 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Pkinase PF00069.20 CCF40800.1 - 4.9e-60 202.8 0.0 9.4e-60 201.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF40800.1 - 4.2e-35 121.0 0.0 6.2e-35 120.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF40800.1 - 5.9e-12 45.1 0.0 1e-10 41.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 CCF40800.1 - 0.045 13.4 0.1 0.41 10.3 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Epimerase PF01370.16 CCF40801.1 - 3.5e-13 49.5 0.1 8.2e-12 45.0 0.1 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 CCF40801.1 - 8.8e-08 31.3 0.6 0.00024 20.0 0.1 2.3 1 1 1 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.14 CCF40801.1 - 2.8e-05 22.9 0.0 0.00011 21.0 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.8 CCF40801.1 - 7.5e-05 22.0 0.2 0.00021 20.6 0.0 1.8 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.1 CCF40801.1 - 0.00011 22.2 0.3 0.00021 21.3 0.2 1.6 1 1 0 1 1 1 1 NADH(P)-binding TrkA_N PF02254.13 CCF40801.1 - 0.08 12.9 0.0 0.36 10.8 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain TOBE_3 PF12857.2 CCF40802.1 - 0.055 13.3 0.9 1.8 8.5 0.2 2.1 2 0 0 2 2 2 0 TOBE-like domain XPG_I PF00867.13 CCF40805.1 - 7.3e-24 83.6 0.0 1.8e-23 82.4 0.0 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 CCF40805.1 - 2.8e-06 27.5 0.0 6.5e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.2 CCF40805.1 - 4e-05 23.2 0.0 0.00012 21.6 0.0 1.7 2 0 0 2 2 2 1 XPG domain containing 5_3_exonuc PF01367.15 CCF40805.1 - 0.082 13.1 0.0 0.25 11.5 0.0 1.8 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold DUF2962 PF11176.3 CCF40806.1 - 1.3e-42 144.9 1.3 1.5e-42 144.7 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2962) Exonuc_VIII PF06630.6 CCF40806.1 - 0.014 14.7 0.1 0.03 13.6 0.1 1.6 1 1 0 1 1 1 0 Enterobacterial exodeoxyribonuclease VIII FliJ PF02050.11 CCF40806.1 - 6.2 6.9 11.4 0.051 13.6 1.9 1.9 3 0 0 3 3 3 0 Flagellar FliJ protein MAM33 PF02330.11 CCF40807.1 - 1.4e-29 103.3 1.1 1e-27 97.2 0.8 2.1 1 1 0 1 1 1 1 Mitochondrial glycoprotein CAP PF00188.21 CCF40808.1 - 1.9e-23 83.3 2.3 2.1e-23 83.1 1.6 1.0 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Mannosyl_trans3 PF11051.3 CCF40810.1 - 1.1e-50 172.5 0.0 1.4e-50 172.1 0.0 1.1 1 0 0 1 1 1 1 Mannosyltransferase putative Glyco_hydro_3 PF00933.16 CCF40811.1 - 3.5e-39 134.5 0.0 4.4e-39 134.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 CCF40811.1 - 1.7e-07 31.0 0.0 3e-05 23.6 0.0 2.4 1 1 0 2 2 2 2 Glycosyl hydrolase family 3 C-terminal domain AA_permease PF00324.16 CCF40812.1 - 5.8e-07 28.2 7.9 9.7e-07 27.4 5.4 1.3 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF40812.1 - 2.8e-06 26.1 9.3 3.3e-06 25.9 6.5 1.0 1 0 0 1 1 1 1 Amino acid permease OPT PF03169.10 CCF40813.1 - 1.1e-45 156.3 37.9 1.2e-45 156.0 26.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein ACT PF01842.20 CCF40814.1 - 0.0055 16.1 0.0 0.0076 15.7 0.0 1.2 1 0 0 1 1 1 1 ACT domain p450 PF00067.17 CCF40816.1 - 1e-48 166.0 0.0 1.2e-48 165.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 F-box-like PF12937.2 CCF40817.1 - 1.6e-05 24.5 0.1 3.4e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF40817.1 - 0.00013 21.5 0.1 0.00028 20.4 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like_2 PF13013.1 CCF40817.1 - 0.048 13.3 1.9 0.079 12.6 1.3 1.8 1 1 0 1 1 1 0 F-box-like domain Methyltransf_23 PF13489.1 CCF40818.1 - 1.7e-22 79.8 0.0 2.5e-22 79.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF40818.1 - 7.8e-09 35.9 0.0 1.4e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF40818.1 - 1.2e-08 34.7 0.0 1.6e-07 31.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF40818.1 - 1.1e-07 32.3 0.1 2.3e-06 28.1 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF40818.1 - 5.9e-07 29.8 0.0 6.4e-06 26.5 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF40818.1 - 3.8e-05 23.9 0.0 9.2e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.7 CCF40818.1 - 0.0051 15.7 0.0 0.0094 14.8 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase MTS PF05175.9 CCF40818.1 - 0.013 14.8 0.0 0.026 13.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_26 PF13659.1 CCF40818.1 - 0.042 13.8 0.0 0.12 12.4 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.14 CCF40818.1 - 0.1 12.6 0.0 0.22 11.4 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase PrmA PF06325.8 CCF40818.1 - 0.13 11.3 0.0 0.22 10.5 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) p450 PF00067.17 CCF40819.1 - 2.7e-77 260.2 0.0 3.6e-77 259.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.15 CCF40819.1 - 1.3e-33 116.3 0.0 9.2e-33 113.5 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.20 CCF40819.1 - 1.2e-26 93.4 0.0 2.5e-26 92.3 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 CCF40819.1 - 3.7e-13 49.9 0.0 9.9e-13 48.6 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.2 CCF40819.1 - 0.00042 20.3 0.0 0.0026 17.7 0.0 2.1 2 0 0 2 2 2 1 Flavodoxin domain Flavodoxin_NdrI PF07972.6 CCF40819.1 - 0.0054 16.6 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 NrdI Flavodoxin like DcpS_C PF11969.3 CCF40820.1 - 1.1e-30 106.1 0.1 1.9e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.7 CCF40820.1 - 1.9e-26 92.6 0.0 3.2e-26 91.8 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal GILT PF03227.11 CCF40821.1 - 2.9e-12 46.4 0.1 4.2e-12 45.8 0.1 1.3 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) ERM PF00769.14 CCF40822.1 - 0.00074 19.1 1.3 0.0014 18.2 0.9 1.4 1 0 0 1 1 1 1 Ezrin/radixin/moesin family MscS_TM PF12794.2 CCF40822.1 - 6.1 5.3 5.9 9 4.7 4.1 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Glyco_transf_90 PF05686.7 CCF40823.1 - 9.1e-14 50.9 1.7 1.1e-10 40.7 0.0 2.7 3 0 0 3 3 3 2 Glycosyl transferase family 90 Nop53 PF07767.6 CCF40824.1 - 1.8e-36 126.0 14.2 2.5e-36 125.5 9.9 1.2 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Miff PF05644.6 CCF40824.1 - 0.066 12.8 3.4 0.089 12.4 2.4 1.1 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff DUF3245 PF11595.3 CCF40824.1 - 0.15 12.3 9.7 0.24 11.6 6.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) MRC1 PF09444.5 CCF40824.1 - 0.52 10.6 12.3 0.89 9.8 8.5 1.4 1 0 0 1 1 1 0 MRC1-like domain VIT1 PF01988.14 CCF40824.1 - 0.87 9.0 3.4 1.1 8.6 2.4 1.1 1 0 0 1 1 1 0 VIT family Pyr_redox_2 PF07992.9 CCF40825.1 - 2.8e-22 79.5 0.0 4.1e-22 79.0 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF40825.1 - 4.4e-15 55.8 0.0 3.6e-10 40.0 0.0 3.5 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.27 CCF40825.1 - 9.6e-07 27.6 0.3 2e-06 26.6 0.2 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 CCF40825.1 - 4.1e-06 26.2 0.6 1.8e-05 24.2 0.4 2.1 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 CCF40825.1 - 8.7e-06 25.7 0.2 2.4e-05 24.3 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 CCF40825.1 - 1.5e-05 24.1 1.8 3.2e-05 23.0 1.2 1.5 1 0 0 1 1 1 1 EF hand Pyr_redox_3 PF13738.1 CCF40825.1 - 0.011 15.7 0.0 0.64 10.0 0.0 2.9 2 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase PTPS PF01242.14 CCF40825.1 - 0.068 12.8 0.1 7.6 6.2 0.0 2.8 3 0 0 3 3 3 0 6-pyruvoyl tetrahydropterin synthase Methyltransf_23 PF13489.1 CCF40826.1 - 1.7e-21 76.5 0.0 3.4e-21 75.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF40826.1 - 6.3e-11 42.6 0.0 2.1e-10 40.9 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF40826.1 - 8.2e-11 41.7 0.0 2.3e-09 36.9 0.0 2.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF40826.1 - 1.9e-08 34.8 0.0 3.2e-07 30.9 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF40826.1 - 3e-08 34.0 0.0 2.7e-07 30.9 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF40826.1 - 1.6e-06 28.3 0.0 4.1e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF40826.1 - 0.0003 19.9 0.0 0.00063 18.8 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase CMAS PF02353.15 CCF40826.1 - 0.0036 16.4 0.0 0.0066 15.5 0.0 1.4 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase FtsJ PF01728.14 CCF40826.1 - 0.0043 17.0 0.0 0.0081 16.1 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_26 PF13659.1 CCF40826.1 - 0.0096 15.9 0.0 0.047 13.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF40826.1 - 0.057 12.5 0.0 0.95 8.5 0.0 2.5 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family MTS PF05175.9 CCF40826.1 - 0.064 12.6 0.0 0.19 11.0 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_2 PF00891.13 CCF40826.1 - 0.11 11.6 0.0 1.3 8.1 0.0 2.2 2 0 0 2 2 2 0 O-methyltransferase FA_desaturase PF00487.19 CCF40829.1 - 0.043 13.2 0.1 0.048 13.0 0.0 1.2 1 0 0 1 1 1 0 Fatty acid desaturase DUF418 PF04235.7 CCF40829.1 - 0.12 12.0 2.7 0.16 11.6 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF418) FAD_binding_3 PF01494.14 CCF40830.1 - 1.2e-13 50.8 0.0 1.5e-13 50.5 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain SE PF08491.5 CCF40830.1 - 0.043 12.6 0.0 0.053 12.3 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase 2-Hacid_dh_C PF02826.14 CCF40831.1 - 1.2e-50 171.1 0.0 1.7e-50 170.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.10 CCF40831.1 - 2.3e-06 27.5 0.3 4.9e-06 26.4 0.2 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh PF00389.25 CCF40831.1 - 0.00084 18.8 0.0 0.0013 18.2 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AdoHcyase_NAD PF00670.16 CCF40831.1 - 0.00086 19.1 0.1 0.0014 18.4 0.1 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.7 CCF40831.1 - 0.0026 17.1 0.0 0.0042 16.4 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain 3HCDH_N PF02737.13 CCF40831.1 - 0.003 17.2 2.2 0.56 9.8 0.3 2.6 2 1 1 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XdhC_C PF13478.1 CCF40831.1 - 0.017 15.4 0.0 0.029 14.6 0.0 1.4 1 0 0 1 1 1 0 XdhC Rossmann domain ACT PF01842.20 CCF40831.1 - 0.046 13.2 0.0 0.1 12.0 0.0 1.7 1 0 0 1 1 1 0 ACT domain GMC_oxred_N PF00732.14 CCF40832.1 - 9.2e-52 176.0 0.0 1.1e-51 175.7 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 CCF40832.1 - 2e-06 26.9 0.1 0.0038 16.1 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 CCF40832.1 - 2.1e-06 26.8 0.0 5.2e-05 22.3 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF40832.1 - 0.00017 21.5 0.0 0.00049 20.0 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF40832.1 - 0.00068 19.5 0.0 0.0037 17.1 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF40832.1 - 0.0011 19.0 0.1 0.029 14.4 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF40832.1 - 0.0012 17.8 0.1 0.0017 17.3 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.9 CCF40832.1 - 0.0065 14.9 0.0 0.096 11.1 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.12 CCF40832.1 - 0.015 14.3 0.1 0.048 12.7 0.0 1.7 2 0 0 2 2 2 0 Thi4 family NAD_binding_9 PF13454.1 CCF40832.1 - 0.016 15.0 0.2 0.087 12.5 0.0 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding RhoGAP PF00620.22 CCF40833.1 - 2e-46 157.3 2.2 5.4e-46 155.9 0.0 2.7 2 2 1 3 3 3 1 RhoGAP domain GAGA_bind PF06217.7 CCF40833.1 - 0.00013 22.0 1.1 0.00026 21.0 0.2 1.9 1 1 1 2 2 2 1 GAGA binding protein-like family SlyX PF04102.7 CCF40833.1 - 0.0056 17.0 1.2 0.0056 17.0 0.8 3.6 3 1 0 3 3 3 1 SlyX Metal_resist PF13801.1 CCF40833.1 - 3.2 7.7 7.5 5.9 6.8 4.4 2.0 2 0 0 2 2 2 0 Heavy-metal resistance rRNA_processing PF08524.6 CCF40834.1 - 0.00043 20.1 7.9 0.00048 19.9 5.5 1.0 1 0 0 1 1 1 1 rRNA processing Med3 PF11593.3 CCF40834.1 - 0.24 10.5 0.9 0.26 10.4 0.6 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal ATP-synt_E PF05680.7 CCF40834.1 - 0.54 10.2 4.8 0.7 9.8 3.4 1.2 1 0 0 1 1 1 0 ATP synthase E chain NARP1 PF12569.3 CCF40834.1 - 0.83 8.3 6.4 0.85 8.2 4.4 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 U79_P34 PF03064.11 CCF40834.1 - 0.89 9.0 7.3 0.97 8.9 5.0 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Pinin_SDK_memA PF04696.8 CCF40834.1 - 1.7 8.2 11.3 2.2 7.8 7.8 1.2 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region DUF4337 PF14235.1 CCF40834.1 - 3.5 7.4 5.3 4.1 7.2 3.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF1682 PF07946.9 CCF40834.1 - 7.6 5.2 12.9 9.3 4.9 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) NmrA PF05368.8 CCF40836.1 - 1.9e-21 76.4 0.2 2.4e-21 76.0 0.2 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF40836.1 - 5.6e-17 62.3 0.1 9.5e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 CCF40836.1 - 4.4e-06 25.9 0.7 0.00063 18.8 0.1 2.1 2 0 0 2 2 2 2 Saccharopine dehydrogenase 3Beta_HSD PF01073.14 CCF40836.1 - 1.9e-05 23.5 0.4 5.9e-05 21.9 0.1 1.8 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 CCF40836.1 - 0.0011 18.4 0.2 0.0023 17.3 0.1 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.19 CCF40836.1 - 0.016 15.4 1.4 0.43 10.9 0.2 2.3 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 CCF40836.1 - 1.1 9.1 4.4 0.94 9.4 0.4 2.7 3 1 0 3 3 3 0 Dihydrodipicolinate reductase, N-terminus Acetyltransf_7 PF13508.1 CCF40837.1 - 0.0029 17.7 0.0 0.0061 16.7 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CCF40837.1 - 0.014 15.5 0.0 0.35 10.9 0.0 2.2 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain MOZ_SAS PF01853.13 CCF40837.1 - 0.04 13.1 0.0 0.059 12.6 0.0 1.2 1 0 0 1 1 1 0 MOZ/SAS family Acetyltransf_1 PF00583.19 CCF40837.1 - 0.041 13.9 0.0 0.15 12.1 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family MAPEG PF01124.13 CCF40839.1 - 1.4e-20 73.2 0.2 1.7e-20 72.9 0.1 1.0 1 0 0 1 1 1 1 MAPEG family EthD PF07110.6 CCF40841.1 - 2.7e-22 79.4 0.1 3.9e-22 78.9 0.1 1.2 1 0 0 1 1 1 1 EthD domain tRNA-synt_1e PF01406.14 CCF40842.1 - 1.1e-111 372.8 0.0 1.5e-111 372.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 CCF40842.1 - 7.1e-07 28.2 0.4 0.025 13.2 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) DALR_2 PF09190.6 CCF40842.1 - 0.0024 18.0 0.2 0.0062 16.7 0.1 1.7 1 0 0 1 1 1 1 DALR domain GCD14 PF08704.5 CCF40843.1 - 4.9e-56 189.9 0.0 5.4e-41 140.7 0.0 2.2 2 0 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Methyltransf_26 PF13659.1 CCF40843.1 - 0.013 15.5 0.0 0.035 14.1 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_18 PF12847.2 CCF40843.1 - 0.11 13.1 0.0 2.2 8.8 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Myb_DNA-binding PF00249.26 CCF40844.1 - 0.0033 17.4 0.0 0.55 10.3 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Ketoacyl-synt_C PF02801.17 CCF40845.1 - 3.9e-37 126.7 0.0 7.3e-37 125.8 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.21 CCF40845.1 - 9e-28 97.4 0.4 7.8e-13 48.4 0.0 2.3 1 1 1 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain PEMT PF04191.8 CCF40848.1 - 1.9e-05 24.7 0.0 7e-05 22.8 0.0 1.9 2 0 0 2 2 2 1 Phospholipid methyltransferase ICMT PF04140.9 CCF40848.1 - 6.6e-05 23.0 0.0 0.00015 21.8 0.0 1.6 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF2985 PF11204.3 CCF40849.1 - 2.9e-36 123.0 0.8 2.9e-36 123.0 0.6 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2985) DUF2244 PF10003.4 CCF40849.1 - 3 7.2 6.8 5.9 6.2 0.6 2.3 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) Cu_bind_like PF02298.12 CCF40850.1 - 0.0082 15.9 0.2 0.032 14.0 0.1 1.8 1 1 0 1 1 1 1 Plastocyanin-like domain DUF2360 PF10152.4 CCF40850.1 - 0.11 12.7 5.4 0.38 11.0 3.8 1.7 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) DUF4449 PF14613.1 CCF40851.1 - 0.0086 16.0 0.0 0.033 14.1 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF4449) PHD PF00628.24 CCF40852.1 - 1.3e-08 34.3 8.6 2.6e-08 33.4 6.0 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.1 CCF40852.1 - 0.018 14.3 5.3 0.04 13.2 3.7 1.6 1 0 0 1 1 1 0 PHD-finger WHIM2 PF15613.1 CCF40852.1 - 0.068 13.1 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 2 Mem_trans PF03547.13 CCF40852.1 - 0.41 8.8 0.8 0.46 8.7 0.5 1.2 1 0 0 1 1 1 0 Membrane transport protein Ion_trans PF00520.26 CCF40853.1 - 4.5e-107 355.7 74.0 2.3e-34 118.4 7.4 5.2 4 1 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 CCF40853.1 - 0.0027 16.2 0.4 0.0027 16.2 0.3 7.0 6 1 1 7 7 7 6 Polycystin cation channel GAS2 PF02187.12 CCF40853.1 - 0.0042 16.8 0.0 0.016 14.9 0.0 1.9 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain JSRP PF15312.1 CCF40853.1 - 0.017 15.0 0.0 0.061 13.2 0.0 2.0 1 0 0 1 1 1 0 Junctional sarcoplasmic reticulum protein Histidinol_dh PF00815.15 CCF40854.1 - 1.2e-180 600.5 5.6 1.9e-180 599.8 3.9 1.3 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.13 CCF40854.1 - 3e-25 87.6 0.0 5.9e-25 86.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.12 CCF40854.1 - 3.7e-11 43.1 1.3 7.6e-11 42.1 0.1 2.2 2 0 0 2 2 2 1 Phosphoribosyl-ATP pyrophosphohydrolase Phasin_2 PF09361.5 CCF40854.1 - 2.6 8.1 6.1 1.8 8.6 0.2 3.4 4 0 0 4 4 4 0 Phasin protein Peptidase_M16 PF00675.15 CCF40855.1 - 2.6e-57 192.7 1.3 4.8e-57 191.8 0.3 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 CCF40855.1 - 2e-38 131.9 0.1 1.2e-37 129.3 0.0 2.0 2 0 0 2 2 2 1 Peptidase M16 inactive domain Esterase PF00756.15 CCF40855.1 - 0.0013 18.2 0.0 0.0026 17.2 0.0 1.5 1 0 0 1 1 1 1 Putative esterase F-actin_cap_A PF01267.12 CCF40855.1 - 0.018 14.0 0.0 0.032 13.2 0.0 1.4 1 0 0 1 1 1 0 F-actin capping protein alpha subunit Raffinose_syn PF05691.7 CCF40856.1 - 5.6e-56 189.5 1.6 2.3e-45 154.4 0.1 3.1 2 1 1 3 3 3 3 Raffinose synthase or seed imbibition protein Sip1 Glyco_hydro_31 PF01055.21 CCF40856.1 - 1.5e-06 27.3 2.0 2.1e-06 26.8 1.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Melibiase PF02065.13 CCF40856.1 - 0.00029 19.6 1.4 0.00046 18.9 1.0 1.2 1 0 0 1 1 1 1 Melibiase Pribosyltran PF00156.22 CCF40857.1 - 9.5e-18 64.1 0.0 1.6e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 CCF40857.1 - 0.0016 17.7 0.0 0.0023 17.1 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase MFS_1_like PF12832.2 CCF40858.1 - 1.9e-15 56.3 0.0 1.9e-15 56.3 0.0 2.7 2 0 0 2 2 2 1 MFS_1 like family Pex2_Pex12 PF04757.9 CCF40859.1 - 9.8e-42 142.9 1.8 1.8e-41 142.0 1.3 1.3 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.1 CCF40859.1 - 0.0013 18.5 4.0 0.0028 17.4 2.8 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 CCF40859.1 - 0.15 12.1 8.1 0.079 13.0 3.1 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF40859.1 - 0.16 11.6 2.7 0.39 10.4 1.9 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 CCF40859.1 - 0.33 10.7 1.7 0.4 10.4 0.2 1.9 2 0 0 2 2 2 0 RING-type zinc-finger TFIID_30kDa PF03540.8 CCF40861.1 - 1.2e-25 89.0 0.3 1.8e-25 88.4 0.2 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit EBV-NA1 PF02905.9 CCF40861.1 - 0.093 12.2 0.1 0.15 11.5 0.1 1.4 1 0 0 1 1 1 0 Epstein Barr virus nuclear antigen-1, DNA-binding domain FoP_duplication PF13865.1 CCF40861.1 - 0.14 12.5 0.2 0.3 11.5 0.1 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Ribosomal_S19 PF00203.16 CCF40862.1 - 7.1e-24 83.2 0.0 1.1e-23 82.6 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein S19 DUF3433 PF11915.3 CCF40865.1 - 1.8e-07 31.2 1.3 4.2e-07 30.0 0.9 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3433) DUF423 PF04241.10 CCF40867.1 - 0.73 9.8 4.4 0.31 10.9 0.5 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF423) zf-FPG_IleRS PF06827.9 CCF40868.1 - 0.014 15.0 0.4 0.42 10.3 0.0 2.2 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS DUF1660 PF07874.6 CCF40868.1 - 0.058 13.6 2.0 3 8.1 0.0 2.3 1 1 1 2 2 2 0 Prophage protein (DUF1660) Mut7-C PF01927.11 CCF40868.1 - 0.096 12.6 0.2 0.099 12.6 0.1 1.1 1 0 0 1 1 1 0 Mut7-C RNAse domain zf-RING_3 PF14369.1 CCF40868.1 - 1.1 9.2 4.5 6.3 6.8 0.3 2.5 2 0 0 2 2 2 0 zinc-finger Carla_C4 PF01623.12 CCF40868.1 - 3 7.6 6.0 4.9 6.9 0.7 2.2 1 1 1 2 2 2 0 Carlavirus putative nucleic acid binding protein PalH PF08733.5 CCF40869.1 - 7.3e-99 330.8 0.8 1e-98 330.4 0.6 1.1 1 0 0 1 1 1 1 PalH/RIM21 MARVEL PF01284.18 CCF40870.1 - 2.8e-09 36.9 21.0 1.2e-08 34.8 13.9 2.1 1 1 1 2 2 2 1 Membrane-associating domain ADH_zinc_N PF00107.21 CCF40871.1 - 2.6e-05 23.7 0.0 4.5e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Asp PF00026.18 CCF40872.1 - 9.2e-108 360.2 0.1 1.2e-107 359.8 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CCF40872.1 - 1.2e-09 38.3 0.0 2.7e-09 37.1 0.0 1.7 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 CCF40872.1 - 1.3e-06 28.7 0.0 0.011 16.1 0.0 2.8 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.1 CCF40872.1 - 2.3e-05 24.0 0.0 0.00021 20.8 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.1 CCF40872.1 - 0.0042 16.8 0.0 6.2 6.7 0.0 3.2 2 1 1 3 3 3 2 gag-polyprotein putative aspartyl protease Alpha-amylase_C PF02806.13 CCF40872.1 - 0.13 12.4 0.1 0.42 10.7 0.0 1.9 1 0 0 1 1 1 0 Alpha amylase, C-terminal all-beta domain DZR PF12773.2 CCF40873.1 - 0.14 11.9 9.9 7.2 6.5 6.8 2.5 1 1 0 1 1 1 0 Double zinc ribbon DUF1191 PF06697.7 CCF40874.1 - 0.027 13.2 0.0 0.028 13.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) Ank_2 PF12796.2 CCF40876.1 - 1.8e-43 146.7 9.3 1.9e-13 50.5 0.4 5.0 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF40876.1 - 8.1e-30 102.6 7.4 2.6e-09 37.3 0.0 6.5 5 2 2 7 7 7 4 Ankyrin repeats (many copies) SPX PF03105.14 CCF40876.1 - 7.5e-29 101.3 13.0 4.8e-25 88.8 9.0 2.2 1 1 0 1 1 1 1 SPX domain Ank PF00023.25 CCF40876.1 - 2.5e-26 90.1 12.9 1.8e-06 27.4 0.0 8.3 8 0 0 8 8 8 5 Ankyrin repeat Ank_5 PF13857.1 CCF40876.1 - 1.8e-20 72.4 14.1 7.2e-05 22.9 0.0 8.7 3 1 6 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF40876.1 - 2.8e-17 61.0 14.2 0.00085 19.3 0.0 8.8 11 0 0 11 11 11 3 Ankyrin repeat GDPD PF03009.12 CCF40876.1 - 2.7e-07 30.3 0.0 1e-06 28.4 0.0 1.9 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family RVP PF00077.15 CCF40876.1 - 0.033 14.1 0.0 0.21 11.4 0.0 2.2 2 0 0 2 2 2 0 Retroviral aspartyl protease DRAT PF07357.6 CCF40876.1 - 0.097 11.8 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Dinitrogenase reductase ADP-ribosyltransferase (DRAT) Coa1 PF08695.5 CCF40878.1 - 3.2e-28 97.5 0.5 4.8e-24 84.1 0.0 2.1 1 1 1 2 2 2 2 Cytochrome oxidase complex assembly protein 1 Ribosomal_L3 PF00297.17 CCF40879.1 - 1.3e-28 100.1 1.5 2.1e-28 99.4 1.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L3 NAD_synthase PF02540.12 CCF40880.1 - 2.4e-22 79.0 0.0 7.4e-22 77.4 0.0 1.8 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.16 CCF40880.1 - 0.0029 17.1 0.0 0.0048 16.4 0.0 1.4 1 0 0 1 1 1 1 Asparagine synthase Na_Ca_ex PF01699.19 CCF40881.1 - 4.4e-38 130.0 33.5 1e-20 73.7 10.3 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Cation_ATPase_C PF00689.16 CCF40882.1 - 8.7e-34 116.6 13.0 1.6e-33 115.7 9.0 1.5 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CCF40882.1 - 4.8e-30 105.5 0.0 3.4e-28 99.5 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF40882.1 - 4.6e-16 58.5 0.0 8.9e-16 57.6 0.0 1.4 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 CCF40882.1 - 1.3e-12 48.3 0.0 3e-12 47.1 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 CCF40882.1 - 3.4e-06 26.2 0.7 7.3e-06 25.1 0.5 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.7 CCF40882.1 - 0.00015 21.4 0.2 0.00033 20.3 0.1 1.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase YecR PF13992.1 CCF40883.1 - 0.0089 16.1 0.6 0.96 9.6 0.0 2.5 2 1 1 3 3 3 2 YecR-like lipoprotein Glyco_hydro_76 PF03663.9 CCF40884.1 - 2.2e-62 211.5 4.4 2.6e-62 211.3 3.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 GMC_oxred_N PF00732.14 CCF40885.1 - 0.00067 18.9 0.0 0.00083 18.5 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.1 CCF40885.1 - 0.0022 17.9 0.0 0.0033 17.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 CCF40885.1 - 0.0087 15.1 0.0 0.012 14.7 0.0 1.2 1 0 0 1 1 1 1 Thi4 family DAO PF01266.19 CCF40885.1 - 0.016 14.1 0.0 0.02 13.8 0.0 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 CCF40885.1 - 0.04 13.7 0.0 0.054 13.2 0.0 1.2 1 0 0 1 1 1 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.7 CCF40885.1 - 0.049 12.5 0.0 0.069 12.0 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_2 PF00890.19 CCF40885.1 - 0.094 11.5 0.1 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.9 CCF40885.1 - 0.15 10.5 0.0 0.17 10.3 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein Fungal_trans PF04082.13 CCF40886.1 - 8.2e-11 41.2 1.0 1.5e-10 40.4 0.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 CCF40886.1 - 2e-09 37.2 13.6 0.00025 21.1 0.9 3.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type Zn_clus PF00172.13 CCF40886.1 - 4.6e-06 26.4 12.1 4.6e-06 26.4 8.4 2.4 2 1 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_4 PF13894.1 CCF40886.1 - 1.3e-05 25.1 19.9 0.00034 20.7 0.8 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CCF40886.1 - 4.5e-05 23.5 3.2 4.5e-05 23.5 2.2 2.8 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.3 CCF40886.1 - 0.97 9.6 5.6 2.4 8.4 0.7 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 CCF40886.1 - 5.7 6.9 12.0 3.9 7.5 0.8 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger Acyl_transf_3 PF01757.17 CCF40887.1 - 1.7e-43 148.7 32.5 2.2e-43 148.4 22.5 1.2 1 0 0 1 1 1 1 Acyltransferase family DUF1749 PF08538.5 CCF40890.1 - 2e-87 292.9 0.0 2.2e-87 292.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.2 CCF40890.1 - 9.4e-16 58.3 0.0 1.2e-15 58.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF40890.1 - 2.6e-10 40.2 0.0 6.1e-10 39.0 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF40890.1 - 9.2e-06 25.3 0.1 2e-05 24.2 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF40890.1 - 0.00078 18.7 0.0 0.64 9.1 0.0 3.2 2 2 0 3 3 3 1 Prolyl oligopeptidase family Ndr PF03096.9 CCF40890.1 - 0.0051 15.3 0.0 0.007 14.8 0.0 1.1 1 0 0 1 1 1 1 Ndr family Ser_hydrolase PF06821.8 CCF40890.1 - 0.014 14.9 0.0 0.03 13.9 0.0 1.6 1 0 0 1 1 1 0 Serine hydrolase DUF2305 PF10230.4 CCF40890.1 - 0.053 12.9 0.1 0.87 8.9 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2305) Abhydrolase_2 PF02230.11 CCF40890.1 - 0.12 11.8 0.3 2.4 7.5 0.0 2.4 2 1 1 3 3 3 0 Phospholipase/Carboxylesterase DUF3530 PF12048.3 CCF40890.1 - 0.12 11.3 0.0 0.21 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) DUF1886 PF09171.5 CCF40891.1 - 0.017 14.1 0.0 0.021 13.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1886) Suc_Fer-like PF06999.7 CCF40892.1 - 3.2e-49 168.0 0.0 3.8e-49 167.7 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Pkinase PF00069.20 CCF40893.1 - 2.6e-60 203.7 0.0 3.5e-60 203.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF40893.1 - 5e-40 137.2 0.0 6.4e-40 136.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF40893.1 - 1.2e-06 27.6 0.0 2.5e-06 26.6 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.6 CCF40893.1 - 0.062 12.1 0.0 0.088 11.6 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 HAD_2 PF13419.1 CCF40894.1 - 8.8e-13 48.8 0.1 2.6e-09 37.5 0.0 2.8 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CCF40894.1 - 3.1e-09 37.5 0.0 8e-06 26.4 0.0 2.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CCF40894.1 - 1.1e-07 31.4 0.1 1.9e-07 30.6 0.1 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.2 CCF40894.1 - 6.6e-05 23.1 0.0 0.00013 22.2 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.5 CCF40894.1 - 0.0022 17.4 0.0 0.71 9.2 0.0 2.3 2 1 0 2 2 2 2 Mitochondrial PGP phosphatase FUSC_2 PF13515.1 CCF40895.1 - 9.4e-23 80.5 9.4 9.4e-23 80.5 6.5 3.0 2 1 0 2 2 2 1 Fusaric acid resistance protein-like FUSC PF04632.7 CCF40895.1 - 1.9e-07 29.9 0.6 1.9e-07 29.9 0.4 2.6 3 0 0 3 3 3 1 Fusaric acid resistance protein family DUF2421 PF10334.4 CCF40895.1 - 0.0034 17.0 0.0 0.0098 15.5 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2421) ALMT PF11744.3 CCF40895.1 - 1.2 7.6 24.3 5.9 5.4 10.0 4.4 4 1 0 4 4 4 0 Aluminium activated malate transporter FlxA PF14282.1 CCF40896.1 - 0.075 12.9 0.1 0.075 12.9 0.1 1.9 2 0 0 2 2 2 0 FlxA-like protein Rer1 PF03248.8 CCF40897.1 - 1.6e-78 262.3 10.2 1.8e-78 262.1 7.1 1.0 1 0 0 1 1 1 1 Rer1 family FA_desaturase PF00487.19 CCF40897.1 - 0.16 11.3 8.6 1.3 8.3 1.9 2.0 2 0 0 2 2 2 0 Fatty acid desaturase ECH PF00378.15 CCF40898.1 - 1.9e-70 236.8 0.0 2.3e-70 236.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Thg1 PF04446.7 CCF40898.1 - 0.15 11.7 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 tRNAHis guanylyltransferase LRR_8 PF13855.1 CCF40901.1 - 1.6e-34 117.4 36.1 2.4e-08 33.6 3.5 8.0 5 2 1 8 8 8 6 Leucine rich repeat LRR_4 PF12799.2 CCF40901.1 - 4.6e-34 115.4 33.8 1.8e-07 30.5 2.1 10.1 7 2 4 11 11 11 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 CCF40901.1 - 3.1e-15 53.8 42.6 0.032 14.2 0.1 15.4 17 2 1 18 18 18 4 Leucine Rich Repeat LRR_7 PF13504.1 CCF40901.1 - 1.3e-07 30.5 43.9 0.071 13.3 0.4 13.4 15 0 0 15 15 15 3 Leucine rich repeat LRR_6 PF13516.1 CCF40901.1 - 0.00013 21.6 24.4 0.32 11.1 0.3 9.3 10 1 1 11 11 11 2 Leucine Rich repeat LRR_9 PF14580.1 CCF40901.1 - 0.017 14.6 12.8 2 7.9 0.1 5.3 2 2 4 6 6 6 0 Leucine-rich repeat PK PF00224.16 CCF40902.1 - 3.5e-169 561.9 3.1 4.5e-169 561.5 2.2 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 CCF40902.1 - 1.6e-30 105.0 0.0 4.8e-30 103.5 0.0 1.8 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 CCF40902.1 - 2.6e-05 23.2 1.3 0.00011 21.1 0.4 2.1 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.20 CCF40902.1 - 0.029 13.2 0.0 0.73 8.6 0.0 2.2 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain YppG PF14179.1 CCF40903.1 - 2.8 8.5 8.6 2.7 8.6 5.0 1.6 1 1 1 2 2 2 0 YppG-like protein NAD_binding_1 PF00175.16 CCF40904.1 - 6.3e-32 110.3 0.0 2.8e-31 108.2 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 CCF40904.1 - 1.4e-21 76.4 0.0 2.4e-21 75.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 CCF40904.1 - 1.3e-09 38.1 0.0 5.7e-05 23.0 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.6 CCF40904.1 - 0.0069 16.3 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 Siderophore-interacting FAD-binding domain Aminotran_4 PF01063.14 CCF40906.1 - 7.7e-09 35.3 0.0 9.8e-09 35.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV Acyl_transf_1 PF00698.16 CCF40907.1 - 0.014 14.7 0.1 5.4 6.2 0.1 2.4 2 0 0 2 2 2 0 Acyl transferase domain PhyH PF05721.8 CCF40908.1 - 5.8e-59 199.6 0.0 7.4e-59 199.3 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Claudin_2 PF13903.1 CCF40909.1 - 5.1e-07 29.5 5.7 4.1e-06 26.6 3.9 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF1772 PF08592.6 CCF40909.1 - 0.033 13.9 3.2 0.039 13.6 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) BCD PF15461.1 CCF40909.1 - 1.8 7.9 7.0 7.6 5.8 1.0 2.2 2 0 0 2 2 2 0 Beta-carotene 15,15'-dioxygenase S1 PF00575.18 CCF40910.1 - 6.8e-78 256.7 30.7 1e-16 60.7 0.7 9.3 9 0 0 9 9 9 8 S1 RNA binding domain TPR_14 PF13428.1 CCF40910.1 - 1.6e-06 28.2 2.7 0.56 11.0 0.0 5.2 4 2 1 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 CCF40910.1 - 6.7e-06 26.3 3.5 0.18 12.1 0.0 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 CCF40910.1 - 2.7e-05 24.7 0.4 0.31 11.7 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat S1_2 PF13509.1 CCF40910.1 - 7.1e-05 22.6 0.9 1.5 8.7 0.0 4.7 5 0 0 5 5 5 2 S1 domain Ras_bdg_2 PF14847.1 CCF40910.1 - 0.0055 16.6 0.7 5.3 7.0 0.1 4.3 2 2 0 3 3 3 1 Ras-binding domain of Byr2 TPR_17 PF13431.1 CCF40910.1 - 0.019 15.0 0.1 84 3.7 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat RNase_H2_suC PF08615.6 CCF40910.1 - 0.035 13.9 0.0 0.2 11.4 0.0 2.3 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) TPR_6 PF13174.1 CCF40910.1 - 0.054 13.9 0.3 6.9 7.3 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat BPL_C PF02237.12 CCF40910.1 - 0.26 11.0 1.9 1.8 8.2 0.0 3.3 3 1 0 3 3 3 0 Biotin protein ligase C terminal domain Daxx PF03344.10 CCF40910.1 - 0.29 9.5 13.8 0.47 8.8 9.6 1.2 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 CCF40910.1 - 1.7 6.4 21.3 2.5 5.9 14.7 1.1 1 0 0 1 1 1 0 Nop14-like family RNA_pol_Rbc25 PF08292.7 CCF40910.1 - 7.2 6.8 9.6 59 3.8 0.0 5.5 7 0 0 7 7 6 0 RNA polymerase III subunit Rpc25 LsmAD PF06741.8 CCF40912.1 - 1.8e-21 76.0 0.9 1.8e-21 76.0 0.6 2.6 3 0 0 3 3 3 1 LsmAD domain Peptidase_M16 PF00675.15 CCF40913.1 - 1.5e-17 63.7 0.1 2.8e-17 62.8 0.1 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 CCF40913.1 - 1e-14 54.6 0.0 4.8e-14 52.4 0.0 2.0 2 0 0 2 2 2 1 Peptidase M16 inactive domain HTH_9 PF08221.6 CCF40914.1 - 5.7e-11 42.1 0.3 1.2e-08 34.6 0.1 2.4 2 0 0 2 2 2 2 RNA polymerase III subunit RPC82 helix-turn-helix domain RNA_pol_Rpc82 PF05645.8 CCF40914.1 - 0.037 13.5 0.0 2.2 7.7 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 TFIIE_alpha PF02002.12 CCF40914.1 - 0.045 13.2 0.0 0.29 10.6 0.0 2.1 2 1 1 3 3 3 0 TFIIE alpha subunit zf-ZPR1 PF03367.8 CCF40916.1 - 0.24 10.5 0.8 0.99 8.5 0.0 1.9 1 1 1 2 2 2 0 ZPR1 zinc-finger domain Pyr_redox_3 PF13738.1 CCF40917.1 - 3.3e-18 66.4 0.0 8e-18 65.2 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 CCF40917.1 - 1e-16 60.2 1.1 2.7e-14 52.2 0.6 2.8 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like K_oxygenase PF13434.1 CCF40917.1 - 1.3e-10 40.6 0.1 2e-07 30.2 0.0 3.2 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 CCF40917.1 - 4.7e-06 26.5 0.0 1.2e-05 25.1 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF40917.1 - 5.5e-06 26.3 0.0 0.00018 21.4 0.0 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF40917.1 - 0.017 14.9 0.0 1.2 8.9 0.0 2.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding Methyltransf_12 PF08242.7 CCF40918.1 - 3e-11 43.6 0.0 6.1e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF40918.1 - 7.9e-08 32.1 0.0 1.5e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.20 CCF40918.1 - 4.5e-06 26.8 0.0 1.2e-05 25.5 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_31 PF13847.1 CCF40918.1 - 0.00015 21.4 0.0 0.00026 20.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF40918.1 - 0.00034 20.9 0.0 0.0011 19.2 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF40918.1 - 0.0089 16.6 0.0 0.019 15.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF40918.1 - 0.014 15.4 0.0 0.054 13.5 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain RrnaAD PF00398.15 CCF40918.1 - 0.015 14.3 0.0 0.035 13.1 0.0 1.6 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_11 PF08241.7 CCF40918.1 - 0.019 15.4 0.0 0.036 14.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.4 CCF40918.1 - 0.067 12.6 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Dynamin_N PF00350.18 CCF40920.1 - 8.8e-44 149.2 0.0 1.6e-43 148.4 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 CCF40920.1 - 8.9e-10 37.8 0.1 9.2e-08 31.1 0.0 2.3 2 0 0 2 2 2 2 Dynamin central region Miro PF08477.8 CCF40920.1 - 0.0012 19.2 0.0 0.0027 18.1 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 CCF40920.1 - 0.0012 18.7 0.0 0.004 17.0 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.1 CCF40920.1 - 0.048 13.6 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.1 CCF40920.1 - 0.096 12.6 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 CCF40920.1 - 0.12 11.8 0.0 15 5.0 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.1 CCF40920.1 - 0.12 12.3 0.1 0.12 12.3 0.0 2.5 3 1 0 3 3 3 0 AAA ATPase domain Cation_efflux PF01545.16 CCF40921.1 - 7.8e-16 57.9 0.6 9.3e-16 57.7 0.4 1.0 1 0 0 1 1 1 1 Cation efflux family DUF1418 PF07214.7 CCF40921.1 - 0.34 10.5 2.1 0.54 9.9 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1418) Ferric_reduct PF01794.14 CCF40922.1 - 1.1e-19 70.7 21.3 1.3e-19 70.5 9.8 2.8 2 1 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 CCF40922.1 - 1.6e-12 47.2 0.0 3.5e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 CCF40922.1 - 7.7e-06 25.8 0.0 1.2e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain DUF2075 PF09848.4 CCF40922.1 - 0.021 13.8 0.0 0.028 13.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF4401 PF14351.1 CCF40922.1 - 0.61 9.0 22.4 0.23 10.4 12.4 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4401) DUF4405 PF14358.1 CCF40922.1 - 1.7 8.8 15.2 0.47 10.6 1.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) Cupin_1 PF00190.17 CCF40923.1 - 8e-30 103.1 0.0 8.9e-16 57.6 0.0 2.2 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.6 CCF40923.1 - 2.2e-27 94.3 0.7 3.8e-13 48.7 0.1 2.3 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.7 CCF40923.1 - 1.3e-09 37.3 0.0 0.00021 20.5 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.14 CCF40923.1 - 6.8e-08 32.2 0.2 0.00021 20.9 0.0 2.4 2 0 0 2 2 2 2 AraC-like ligand binding domain MannoseP_isomer PF01050.13 CCF40923.1 - 6.6e-05 22.5 0.0 0.015 14.8 0.0 2.2 2 0 0 2 2 2 2 Mannose-6-phosphate isomerase 3-HAO PF06052.7 CCF40923.1 - 0.0042 16.5 0.0 0.037 13.4 0.0 2.1 2 0 0 2 2 2 1 3-hydroxyanthranilic acid dioxygenase GPI PF06560.6 CCF40923.1 - 0.019 14.0 0.0 0.056 12.4 0.0 1.8 1 1 1 2 2 2 0 Glucose-6-phosphate isomerase (GPI) ARD PF03079.9 CCF40923.1 - 0.063 13.2 3.5 1.8 8.5 0.0 2.5 3 0 0 3 3 3 0 ARD/ARD' family 2OG-FeII_Oxy_5 PF13759.1 CCF40923.1 - 0.073 13.3 0.1 5.2 7.4 0.0 3.1 2 1 0 2 2 2 0 Putative 2OG-Fe(II) oxygenase Cupin_7 PF12973.2 CCF40923.1 - 0.13 12.1 0.8 0.95 9.3 0.1 2.7 3 1 0 4 4 4 0 ChrR Cupin-like domain DUF3140 PF11338.3 CCF40924.1 - 7.4e-30 102.9 1.3 7.4e-30 102.9 0.9 3.4 2 1 1 3 3 3 1 Protein of unknown function (DUF3140) Sec8_exocyst PF04048.9 CCF40926.1 - 2.2e-47 160.2 0.3 5.2e-47 159.0 0.2 1.7 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain DUF2450 PF10475.4 CCF40926.1 - 1.4e-08 33.9 0.4 2.6e-08 33.1 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) Mannosyl_trans2 PF04188.8 CCF40928.1 - 3.2e-70 237.2 3.0 3.8e-70 237.0 2.1 1.0 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V)) Prp19_bind PF06991.6 CCF40929.1 - 1.1e-18 67.4 6.5 1.9e-18 66.7 4.5 1.3 1 0 0 1 1 1 1 Splicing factor, Prp19-binding domain Pol_alpha_B_N PF08418.5 CCF40930.1 - 1.2e-62 211.7 0.6 2e-62 211.0 0.4 1.3 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.11 CCF40930.1 - 4e-43 147.1 0.1 5.5e-43 146.6 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B NMO PF03060.10 CCF40931.1 - 3e-67 227.1 0.1 3.6e-67 226.8 0.1 1.0 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 CCF40931.1 - 4.4e-06 25.8 0.0 0.037 12.9 0.0 2.6 3 0 0 3 3 3 2 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 CCF40931.1 - 0.0071 15.2 2.1 0.012 14.4 1.5 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase zf-C2H2 PF00096.21 CCF40933.1 - 1.7e-13 49.9 19.6 0.0079 16.4 0.3 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF40933.1 - 2.5e-12 46.1 11.3 0.056 13.7 0.0 5.5 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_6 PF13912.1 CCF40933.1 - 7.4e-10 38.3 12.7 8.8e-05 22.2 0.0 5.1 5 0 0 5 5 5 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CCF40933.1 - 2.1e-05 24.5 16.9 0.023 14.9 0.2 5.4 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_jaz PF12171.3 CCF40933.1 - 0.0062 16.6 7.2 5.9 7.1 0.0 5.2 5 0 0 5 5 5 1 Zinc-finger double-stranded RNA-binding Trm112p PF03966.11 CCF40933.1 - 0.0087 16.4 1.1 0.31 11.4 0.3 2.9 2 1 0 2 2 2 1 Trm112p-like protein zf-Di19 PF05605.7 CCF40933.1 - 0.026 14.6 16.8 0.73 9.9 3.8 3.5 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook PF04423.9 CCF40933.1 - 0.027 13.9 4.7 1.9 8.0 0.1 3.9 2 1 1 3 3 3 0 Rad50 zinc hook motif zf-C2H2_2 PF12756.2 CCF40933.1 - 0.03 14.4 17.2 6 7.0 1.4 5.0 2 2 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C4 PF00105.13 CCF40933.1 - 0.043 14.0 0.4 0.043 14.0 0.3 3.0 3 0 0 3 3 3 0 Zinc finger, C4 type (two domains) zinc-ribbons_6 PF07191.7 CCF40933.1 - 0.09 12.5 9.8 1.1 9.1 0.7 3.5 3 1 1 4 4 4 0 zinc-ribbons TerY-C PF15616.1 CCF40933.1 - 0.5 10.2 5.8 0.53 10.2 0.5 2.7 2 1 0 2 2 2 0 TerY-C metal binding domain zf-RING_3 PF14369.1 CCF40933.1 - 0.99 9.4 4.8 1.7 8.7 0.0 3.5 4 0 0 4 4 4 0 zinc-finger zinc_ribbon_4 PF13717.1 CCF40933.1 - 1.4 8.6 10.2 13 5.5 0.1 4.8 5 0 0 5 5 5 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 CCF40933.1 - 4.6 6.9 11.5 18 5.0 0.2 4.8 5 0 0 5 5 5 0 zinc-ribbon domain CGGC PF08821.6 CCF40933.1 - 4.7 7.3 8.0 0.98 9.5 0.3 2.6 2 1 1 3 3 3 0 CGGC domain zf-NADH-PPase PF09297.6 CCF40933.1 - 5 6.7 9.6 27 4.3 0.1 4.2 4 0 0 4 4 4 0 NADH pyrophosphatase zinc ribbon domain DUF3795 PF12675.2 CCF40933.1 - 7.6 6.7 11.3 6.8 6.9 1.7 3.1 2 2 0 2 2 2 0 Protein of unknown function (DUF3795) Taxilin PF09728.4 CCF40935.1 - 6.5e-46 156.8 26.6 7.5e-46 156.6 18.4 1.0 1 0 0 1 1 1 1 Myosin-like coiled-coil protein Syntaxin PF00804.20 CCF40935.1 - 0.008 16.3 7.0 0.008 16.3 4.8 2.3 1 1 1 2 2 2 1 Syntaxin BLOC1_2 PF10046.4 CCF40935.1 - 0.044 13.9 12.5 0.07 13.2 3.2 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4201 PF13870.1 CCF40935.1 - 0.054 12.9 19.7 0.34 10.3 13.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) Laminin_I PF06008.9 CCF40935.1 - 0.087 12.1 18.5 0.17 11.1 8.0 2.1 1 1 1 2 2 2 0 Laminin Domain I DUF4200 PF13863.1 CCF40935.1 - 0.11 12.4 29.0 0.85 9.5 12.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) ERM PF00769.14 CCF40935.1 - 0.11 11.9 25.9 0.38 10.2 17.9 1.7 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF4559 PF15112.1 CCF40935.1 - 0.22 10.6 11.8 0.11 11.6 6.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4559) DUF4239 PF14023.1 CCF40935.1 - 0.27 10.5 7.5 0.37 10.1 5.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) FliD_N PF02465.13 CCF40935.1 - 0.41 11.0 10.8 26 5.2 1.0 2.6 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 N-terminus DUF1492 PF07374.6 CCF40935.1 - 0.56 10.3 10.3 1.6 8.8 1.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1492) CENP-F_leu_zip PF10473.4 CCF40935.1 - 0.77 9.6 25.3 0.69 9.7 8.8 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Vac_Fusion PF02346.11 CCF40935.1 - 0.77 9.2 5.3 0.32 10.4 1.2 2.1 2 0 0 2 2 2 0 Chordopoxvirus fusion protein IncA PF04156.9 CCF40935.1 - 0.77 9.3 14.5 3.5 7.1 10.2 1.7 1 1 1 2 2 2 0 IncA protein Cep57_CLD_2 PF14197.1 CCF40935.1 - 0.78 9.7 10.5 0.068 13.1 1.8 2.6 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF972 PF06156.8 CCF40935.1 - 0.84 10.0 15.0 0.21 11.9 6.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF972) WXG100 PF06013.7 CCF40935.1 - 0.88 9.6 9.4 5.8 7.0 0.3 3.3 1 1 1 2 2 2 0 Proteins of 100 residues with WXG Snapin_Pallidin PF14712.1 CCF40935.1 - 0.96 9.7 12.6 0.35 11.2 3.7 2.4 1 1 1 2 2 2 0 Snapin/Pallidin Prominin PF05478.6 CCF40935.1 - 1.1 6.7 9.2 1.3 6.4 6.4 1.1 1 0 0 1 1 1 0 Prominin Sec20 PF03908.8 CCF40935.1 - 1.1 8.9 8.0 0.38 10.4 1.7 2.4 1 1 2 3 3 3 0 Sec20 GAS PF13851.1 CCF40935.1 - 1.9 7.6 25.4 0.69 9.0 12.9 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Borrelia_P83 PF05262.6 CCF40935.1 - 2.7 6.1 18.6 0.043 12.0 6.5 1.9 1 1 1 2 2 2 0 Borrelia P83/100 protein MCPsignal PF00015.16 CCF40935.1 - 2.7 7.4 10.0 3.7 7.0 7.0 1.1 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Laminin_II PF06009.7 CCF40935.1 - 3.2 7.4 13.2 4.7 6.9 6.5 2.0 1 1 1 2 2 2 0 Laminin Domain II Macoilin PF09726.4 CCF40935.1 - 4.8 5.3 17.6 7.3 4.7 12.2 1.3 1 0 0 1 1 1 0 Transmembrane protein Jnk-SapK_ap_N PF09744.4 CCF40935.1 - 5 7.1 23.1 7.8 6.4 8.1 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF2203 PF09969.4 CCF40935.1 - 5.7 7.1 12.5 0.71 10.1 3.0 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF1664 PF07889.7 CCF40935.1 - 7.2 6.4 7.3 4.1 7.2 3.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Ribosomal_S27e PF01667.12 CCF40936.1 - 0.00054 19.4 0.1 1.2 8.7 0.0 2.4 2 0 0 2 2 2 2 Ribosomal protein S27 zinc_ribbon_5 PF13719.1 CCF40936.1 - 0.12 11.9 5.1 0.31 10.6 0.5 2.7 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 CCF40936.1 - 0.12 12.0 4.7 0.3 10.8 0.4 2.7 3 0 0 3 3 3 0 zinc-ribbon domain zf-DNA_Pol PF08996.5 CCF40936.1 - 0.63 9.3 4.1 4.6 6.5 2.8 1.9 1 1 0 1 1 1 0 DNA Polymerase alpha zinc finger Sugar_tr PF00083.19 CCF40937.1 - 5.3e-31 107.6 4.5 5.7e-31 107.5 3.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF40937.1 - 5.5e-13 48.3 11.0 6.4e-13 48.1 7.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily COPI_assoc PF08507.5 CCF40937.1 - 0.032 13.9 2.9 0.043 13.5 2.0 1.2 1 0 0 1 1 1 0 COPI associated protein PQQ_3 PF13570.1 CCF40937.1 - 1.1 9.5 0.1 1.1 9.5 0.1 2.4 3 0 0 3 3 3 0 PQQ-like domain HlyIII PF03006.15 CCF40938.1 - 4.7e-30 104.6 6.1 5.8e-30 104.3 4.3 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF962 PF06127.6 CCF40938.1 - 0.093 12.6 0.5 0.14 12.0 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF962) TMA7 PF09072.5 CCF40939.1 - 1.2e-25 89.7 17.3 1.3e-25 89.5 12.0 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 Nefa_Nip30_N PF10187.4 CCF40939.1 - 0.012 15.7 0.9 0.016 15.4 0.6 1.1 1 0 0 1 1 1 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 SPT6_acidic PF14632.1 CCF40939.1 - 0.058 13.5 1.1 0.073 13.2 0.8 1.2 1 0 0 1 1 1 0 Acidic N-terminal SPT6 MFS_1 PF07690.11 CCF40941.1 - 1.5e-38 132.4 35.0 1.5e-38 132.4 24.3 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF40941.1 - 0.00047 18.4 5.0 0.00047 18.4 3.5 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Saccharop_dh PF03435.13 CCF40942.1 - 2.4e-91 306.6 0.0 2.9e-91 306.3 0.0 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 CCF40942.1 - 8.3e-08 32.4 0.2 1.3e-07 31.7 0.1 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.12 CCF40942.1 - 0.01 16.2 0.1 0.021 15.2 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent ThiF PF00899.16 CCF40942.1 - 0.15 11.9 0.0 16 5.3 0.0 2.4 1 1 1 2 2 2 0 ThiF family TatD_DNase PF01026.16 CCF40943.1 - 4.1e-40 137.6 0.0 5.2e-40 137.2 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase zf-C2H2_4 PF13894.1 CCF40944.1 - 0.052 13.8 5.8 1.6 9.2 0.1 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF40944.1 - 0.067 13.5 5.3 3 8.3 0.6 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type Sterol-sensing PF12349.3 CCF40945.1 - 2.9e-38 130.7 9.8 5e-38 129.9 6.8 1.3 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.13 CCF40945.1 - 2.9e-11 42.0 5.0 4.1e-11 41.5 3.4 1.1 1 0 0 1 1 1 1 Patched family MMPL PF03176.10 CCF40945.1 - 0.0036 16.0 0.0 0.0081 14.9 0.0 1.5 1 0 0 1 1 1 1 MMPL family Erp_C PF06780.6 CCF40946.1 - 0.069 12.9 0.1 0.85 9.4 0.0 2.4 2 2 0 3 3 3 0 Erp protein C-terminus DUF2786 PF10979.3 CCF40946.1 - 0.14 11.9 3.7 0.53 10.0 2.6 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2786) TMF_TATA_bd PF12325.3 CCF40946.1 - 0.19 11.4 0.1 0.19 11.4 0.0 3.0 2 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding DivIC PF04977.10 CCF40946.1 - 2.1 7.9 6.5 5.6 6.5 0.3 3.5 1 1 3 4 4 4 0 Septum formation initiator DUF848 PF05852.6 CCF40946.1 - 2.4 8.0 5.4 1.8 8.4 0.3 2.8 2 1 2 4 4 4 0 Gammaherpesvirus protein of unknown function (DUF848) CENP-F_leu_zip PF10473.4 CCF40946.1 - 4 7.2 8.4 13 5.6 0.1 3.4 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin_1 PF12718.2 CCF40946.1 - 8 6.3 8.9 2.1 8.2 0.3 2.6 2 1 1 3 3 3 0 Tropomyosin like DnaJ PF00226.26 CCF40947.1 - 2.5e-23 81.5 2.8 2.5e-23 81.5 1.9 2.4 2 0 0 2 2 2 1 DnaJ domain TPR_11 PF13414.1 CCF40947.1 - 4e-19 68.0 1.4 4.9e-08 32.5 0.0 5.0 3 1 2 5 5 5 3 TPR repeat TPR_2 PF07719.12 CCF40947.1 - 3.4e-16 57.7 0.3 0.083 12.8 0.0 8.0 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.23 CCF40947.1 - 8.8e-16 56.7 0.0 0.0033 16.9 0.0 6.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.1 CCF40947.1 - 3.7e-12 46.5 2.6 0.00079 20.0 0.0 4.9 2 1 5 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.1 CCF40947.1 - 7.1e-12 44.8 3.9 0.03 14.9 0.1 7.2 4 3 5 9 9 8 3 Tetratricopeptide repeat TPR_9 PF13371.1 CCF40947.1 - 2.1e-11 43.4 1.4 0.036 13.9 0.0 4.6 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 CCF40947.1 - 7.9e-11 40.9 0.0 0.17 11.7 0.0 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.1 CCF40947.1 - 8.6e-10 38.8 3.2 0.00045 20.5 0.2 4.3 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 CCF40947.1 - 4.6e-07 29.5 0.6 0.024 14.8 0.1 5.0 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 CCF40947.1 - 6e-07 29.3 1.1 1.8 8.5 0.0 5.1 3 3 2 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 CCF40947.1 - 5.1e-06 25.8 1.7 2.4 8.1 0.0 5.4 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_6 PF13174.1 CCF40947.1 - 1.5e-05 25.1 9.1 1.6 9.3 0.0 7.5 9 0 0 9 9 7 1 Tetratricopeptide repeat TPR_15 PF13429.1 CCF40947.1 - 0.00056 19.0 6.5 6.6 5.7 0.0 5.0 3 2 3 6 6 6 1 Tetratricopeptide repeat Apc3 PF12895.2 CCF40947.1 - 0.0013 18.8 5.3 0.09 12.9 0.0 3.9 4 2 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 SLS PF14611.1 CCF40947.1 - 0.017 14.5 0.1 0.028 13.8 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator Enkurin PF13864.1 CCF40947.1 - 2.9 8.1 7.6 0.87 9.8 0.5 3.2 4 0 0 4 4 4 0 Calmodulin-binding Pheromone PF08015.6 CCF40948.1 - 1.5 9.7 4.8 1.7 9.5 3.3 1.2 1 0 0 1 1 1 0 Fungal mating-type pheromone UDPGT PF00201.13 CCF40949.1 - 4.8e-05 22.0 0.0 7e-05 21.5 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_28 PF03033.15 CCF40949.1 - 0.00014 21.6 0.1 0.0003 20.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_tran_28_C PF04101.11 CCF40949.1 - 0.0011 18.6 0.0 0.0019 17.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain AAA_19 PF13245.1 CCF40949.1 - 0.018 14.8 0.7 0.056 13.2 0.1 2.2 2 0 0 2 2 2 0 Part of AAA domain p450 PF00067.17 CCF40950.1 - 3.9e-49 167.4 0.0 5.5e-49 166.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.20 CCF40951.1 - 5e-21 75.3 2.8 2e-20 73.3 1.9 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF40951.1 - 8.5e-15 55.1 0.1 2.8e-14 53.4 0.1 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF40951.1 - 6.8e-07 29.1 1.3 6.8e-07 29.1 0.9 1.7 2 0 0 2 2 2 1 KR domain TrkA_N PF02254.13 CCF40951.1 - 0.00013 21.9 0.1 0.00022 21.2 0.1 1.4 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_10 PF13460.1 CCF40951.1 - 0.00017 21.6 0.5 0.00045 20.2 0.4 1.6 2 0 0 2 2 2 1 NADH(P)-binding Epimerase PF01370.16 CCF40951.1 - 0.00049 19.6 0.5 0.0036 16.7 0.2 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF40951.1 - 0.0011 17.8 0.3 0.0016 17.2 0.2 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Saccharop_dh PF03435.13 CCF40951.1 - 0.0049 15.8 0.4 0.0072 15.3 0.3 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Methyltransf_18 PF12847.2 CCF40951.1 - 0.029 14.9 0.0 0.051 14.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain 3HCDH_N PF02737.13 CCF40951.1 - 0.032 13.8 1.9 0.049 13.2 1.3 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ADH_zinc_N PF00107.21 CCF40951.1 - 0.034 13.6 0.2 0.064 12.8 0.1 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Methyltransf_31 PF13847.1 CCF40951.1 - 0.053 13.1 0.0 0.083 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain p450 PF00067.17 CCF40952.1 - 6.4e-55 186.5 0.0 8.9e-55 186.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.20 CCF40953.1 - 7.4e-08 32.4 0.6 1.3e-07 31.7 0.4 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF40953.1 - 1.5e-07 31.4 0.0 3.7e-06 26.8 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Lon_C PF05362.8 CCF40953.1 - 0.032 13.5 0.5 0.06 12.6 0.2 1.5 2 0 0 2 2 2 0 Lon protease (S16) C-terminal proteolytic domain NERD PF08378.6 CCF40954.1 - 0.0042 17.3 0.0 0.0066 16.7 0.0 1.3 1 0 0 1 1 1 1 Nuclease-related domain Tox-REase-7 PF15649.1 CCF40954.1 - 0.056 13.5 0.2 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 7 SPOR PF05036.8 CCF40958.1 - 0.031 14.4 0.1 0.038 14.1 0.1 1.2 1 0 0 1 1 1 0 Sporulation related domain VMA21 PF09446.5 CCF40958.1 - 0.73 9.8 5.5 1.1 9.2 3.8 1.3 1 1 0 1 1 1 0 VMA21-like domain COesterase PF00135.23 CCF40959.1 - 6.9e-39 133.9 0.2 8.2e-39 133.7 0.1 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_5 PF12695.2 CCF40959.1 - 0.00059 19.6 0.5 0.0016 18.2 0.3 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 CCF40959.1 - 0.00099 18.7 0.1 0.0023 17.5 0.1 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF40959.1 - 0.0026 17.6 0.6 0.0061 16.4 0.3 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Semenogelin PF05474.6 CCF40959.1 - 0.18 10.0 0.0 0.23 9.6 0.0 1.1 1 0 0 1 1 1 0 Semenogelin Abhydrolase_6 PF12697.2 CCF40961.1 - 8.8e-32 110.8 0.8 1.3e-31 110.2 0.6 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF40961.1 - 1.8e-18 66.9 0.1 2.9e-17 62.9 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF40961.1 - 3.6e-13 49.5 0.1 3e-12 46.5 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CCF40961.1 - 4.3e-05 23.2 0.0 7.8e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Ndr PF03096.9 CCF40961.1 - 0.0025 16.3 0.0 0.0036 15.8 0.0 1.2 1 0 0 1 1 1 1 Ndr family Peptidase_M16_C PF05193.16 CCF40963.1 - 2e-23 83.0 0.0 5.7e-23 81.5 0.0 1.7 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 CCF40963.1 - 5.8e-07 29.3 0.0 1.4e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Glyco_hydro_61 PF03443.9 CCF40964.1 - 3.6e-69 232.9 0.1 5.2e-69 232.3 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 RAB3GAP2_N PF14655.1 CCF40965.1 - 1.2 8.0 2.6 1.7 7.5 1.8 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus AIP3 PF03915.8 CCF40966.1 - 1.1e-161 538.5 9.3 1.6e-161 538.0 6.5 1.2 1 0 0 1 1 1 1 Actin interacting protein 3 Lectin_N PF03954.9 CCF40966.1 - 0.00084 18.7 2.0 0.0018 17.6 0.1 2.5 2 0 0 2 2 2 1 Hepatic lectin, N-terminal domain FliL PF03748.9 CCF40966.1 - 0.014 15.3 0.1 0.093 12.7 0.1 2.5 1 0 0 1 1 1 0 Flagellar basal body-associated protein FliL DivIC PF04977.10 CCF40966.1 - 0.19 11.2 5.5 6.1 6.4 0.1 3.6 3 0 0 3 3 3 0 Septum formation initiator Reo_sigmaC PF04582.7 CCF40966.1 - 0.34 10.0 2.9 0.97 8.5 0.4 2.6 2 1 1 3 3 3 0 Reovirus sigma C capsid protein ATP-synt_Eps PF04627.8 CCF40967.1 - 2.4e-23 81.4 1.2 2.8e-23 81.1 0.9 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain Mak10 PF04112.8 CCF40968.1 - 7.9e-45 152.0 0.0 9.6e-45 151.8 0.0 1.1 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Rubella_E2 PF05749.6 CCF40968.1 - 0.085 12.0 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 AA_permease PF00324.16 CCF40971.1 - 1.8e-128 428.9 46.8 2.2e-128 428.6 32.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF40971.1 - 3.3e-30 104.9 53.1 4.2e-30 104.6 36.8 1.0 1 0 0 1 1 1 1 Amino acid permease DUF2665 PF11654.3 CCF40971.1 - 0.081 12.5 0.2 0.21 11.1 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2665) DUF1772 PF08592.6 CCF40972.1 - 8.7e-11 41.7 0.1 1.1e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) Zn_clus PF00172.13 CCF40973.1 - 1.3e-06 28.2 7.6 2.3e-06 27.4 5.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF40973.1 - 6.5e-05 21.6 0.0 0.00011 20.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Mac PF12464.3 CCF40973.1 - 0.085 12.8 0.1 0.19 11.7 0.1 1.7 1 0 0 1 1 1 0 Maltose acetyltransferase Sugar_tr PF00083.19 CCF40974.1 - 4.8e-63 213.3 3.4 5.4e-63 213.1 2.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF40974.1 - 3e-08 32.7 7.2 3.9e-08 32.3 5.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Glyco_hydro_17 PF00332.13 CCF40975.1 - 0.022 13.7 0.1 0.041 12.9 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 17 DUF4126 PF13548.1 CCF40976.1 - 0.0035 16.7 0.2 0.0036 16.7 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4126) DUF202 PF02656.10 CCF40976.1 - 0.11 12.7 0.5 0.14 12.4 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF202) DUF606 PF04657.8 CCF40976.1 - 0.11 12.5 0.7 0.13 12.3 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF606 PPP4R2 PF09184.6 CCF40977.1 - 0.14 11.6 6.3 0.17 11.4 4.4 1.1 1 0 0 1 1 1 0 PPP4R2 MIP PF00230.15 CCF40978.1 - 1.5e-12 47.4 3.6 1.7e-12 47.3 2.5 1.0 1 0 0 1 1 1 1 Major intrinsic protein DUF3477 PF11963.3 CCF40979.1 - 0.11 11.4 0.1 0.15 11.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3477) Cyclase PF04199.8 CCF40980.1 - 4.5e-08 32.9 0.0 6.8e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase Peptidase_M28 PF04389.12 CCF40981.1 - 1.2e-30 106.6 0.0 1.6e-30 106.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 CCF40981.1 - 5.7e-06 25.9 0.0 9e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 PA PF02225.17 CCF40981.1 - 0.33 10.6 1.8 6 6.6 0.1 2.7 2 1 1 3 3 3 0 PA domain HGTP_anticodon2 PF12745.2 CCF40984.1 - 2e-75 253.4 4.8 4.1e-75 252.4 3.4 1.5 1 1 0 1 1 1 1 Anticodon binding domain of tRNAs tRNA-synt_His PF13393.1 CCF40984.1 - 9.6e-08 31.4 0.1 2.1e-07 30.3 0.0 1.5 2 0 0 2 2 2 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.15 CCF40984.1 - 6.8e-05 22.7 0.0 0.00025 20.9 0.0 2.0 2 0 0 2 2 2 1 Anticodon binding domain LAGLIDADG_3 PF14528.1 CCF40984.1 - 0.028 14.6 0.1 3.7 7.8 0.0 2.9 3 0 0 3 3 3 0 LAGLIDADG-like domain DUF2457 PF10446.4 CCF40986.1 - 0.62 8.7 33.5 1.5 7.4 19.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Pkinase PF00069.20 CCF40987.1 - 4.4e-56 189.9 0.0 5.8e-56 189.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF40987.1 - 1e-24 87.0 0.0 1.5e-24 86.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF40987.1 - 2.5e-07 29.9 0.0 4.3e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 CCF40987.1 - 0.091 11.8 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family UQ_con PF00179.21 CCF40989.1 - 1.3e-47 160.7 0.0 1.5e-47 160.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CCF40989.1 - 1.4e-05 24.8 0.0 1.9e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 CCF40989.1 - 0.021 14.5 0.1 0.033 13.8 0.1 1.4 1 1 0 1 1 1 0 UEV domain RWD PF05773.17 CCF40989.1 - 0.026 14.4 0.3 0.043 13.7 0.2 1.4 1 1 0 1 1 1 0 RWD domain BRE PF06113.7 CCF40989.1 - 0.12 11.3 0.2 0.2 10.6 0.1 1.3 1 0 0 1 1 1 0 Brain and reproductive organ-expressed protein (BRE) Ribosomal_L31e PF01198.14 CCF40990.1 - 4.7e-36 122.3 1.1 6e-36 121.9 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e RGS PF00615.14 CCF40991.1 - 5.6e-12 45.7 0.0 1.9e-08 34.4 0.0 2.2 2 1 0 2 2 2 2 Regulator of G protein signaling domain SNF2_N PF00176.18 CCF40992.1 - 3.5e-67 226.3 0.0 4.3e-67 226.0 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.6 CCF40992.1 - 7.9e-16 57.9 0.0 1.6e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain ResIII PF04851.10 CCF40992.1 - 0.018 14.9 0.0 0.043 13.6 0.0 1.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit CDO_I PF05995.7 CCF40993.1 - 1.3e-36 125.4 0.0 1.4e-36 125.2 0.0 1.0 1 0 0 1 1 1 1 Cysteine dioxygenase type I DUF1637 PF07847.7 CCF40993.1 - 0.022 14.1 0.7 0.036 13.4 0.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1637) zf-SAP30 PF13866.1 CCF40994.1 - 0.026 14.1 0.1 0.061 12.9 0.1 1.6 1 0 0 1 1 1 0 SAP30 zinc-finger GFA PF04828.9 CCF40995.1 - 2.4e-14 53.0 0.3 5.3e-06 26.2 0.0 3.4 2 1 1 3 3 3 3 Glutathione-dependent formaldehyde-activating enzyme SET PF00856.23 CCF40997.1 - 0.029 14.6 0.0 0.051 13.8 0.0 1.7 1 1 0 1 1 1 0 SET domain PSII_Pbs27 PF13326.1 CCF40997.1 - 0.085 12.8 0.1 0.23 11.4 0.1 1.8 2 0 0 2 2 2 0 Photosystem II Pbs27 Zn_clus PF00172.13 CCF40998.1 - 7.6e-08 32.1 9.0 1.9e-07 30.9 6.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF40998.1 - 1.4e-05 24.0 0.7 2.7e-05 23.2 0.1 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Pyr_redox_3 PF13738.1 CCF40999.1 - 8.9e-17 61.8 0.0 1.5e-15 57.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 CCF40999.1 - 3.1e-12 45.4 0.0 2.1e-09 36.1 0.0 2.0 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like K_oxygenase PF13434.1 CCF40999.1 - 7.1e-09 35.0 0.0 5.8e-07 28.7 0.0 2.1 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 CCF40999.1 - 0.00076 19.4 0.0 0.19 11.5 0.0 2.7 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF40999.1 - 0.077 13.4 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase IlvN PF07991.7 CCF40999.1 - 0.079 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain 3HCDH_N PF02737.13 CCF40999.1 - 0.08 12.5 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_4 PF01565.18 CCF41000.1 - 5.1e-22 77.8 0.7 8.8e-22 77.0 0.5 1.4 1 0 0 1 1 1 1 FAD binding domain Mito_carr PF00153.22 CCF41001.1 - 2.3e-12 46.4 0.0 4.1e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial carrier protein GTP_EFTU PF00009.22 CCF41002.1 - 0.089 12.2 0.2 0.12 11.8 0.1 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain NAD_binding_6 PF08030.7 CCF41003.1 - 4e-24 85.3 0.0 6e-24 84.7 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 CCF41003.1 - 9.2e-23 80.1 0.0 2e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.14 CCF41003.1 - 8.5e-16 58.1 9.8 8.5e-16 58.1 6.8 2.2 1 1 1 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.19 CCF41003.1 - 0.00016 21.7 0.0 0.00044 20.3 0.0 1.7 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain Arginase PF00491.16 CCF41005.1 - 1.1e-78 264.3 0.3 1.4e-78 264.0 0.2 1.0 1 0 0 1 1 1 1 Arginase family Nse4_C PF08743.5 CCF41006.1 - 1.2e-32 111.7 0.1 3e-32 110.5 0.0 1.7 2 0 0 2 2 2 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.1 CCF41006.1 - 2.3e-17 62.5 0.1 1e-16 60.4 0.0 2.2 2 0 0 2 2 2 1 Binding domain of Nse4/EID3 to Nse3-MAGE LPP20 PF02169.11 CCF41006.1 - 0.014 15.4 0.0 0.04 14.0 0.0 1.7 1 0 0 1 1 1 0 LPP20 lipoprotein Dehydrin PF00257.14 CCF41006.1 - 0.028 14.7 0.2 0.074 13.3 0.1 1.7 1 0 0 1 1 1 0 Dehydrin DUF3415 PF11895.3 CCF41009.1 - 0.076 12.8 0.8 0.13 12.1 0.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3415) Serglycin PF04360.7 CCF41009.1 - 1.4 8.6 28.0 1.2 8.8 6.1 2.1 1 1 1 2 2 2 0 Serglycin ketoacyl-synt PF00109.21 CCF41010.1 - 4.9e-51 173.6 0.0 5.4e-51 173.5 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.18 CCF41010.1 - 0.0014 17.6 0.2 0.0029 16.6 0.1 1.5 1 1 0 1 1 1 1 Thiolase, N-terminal domain tRNA-synt_1g PF09334.6 CCF41013.1 - 9.4e-120 399.8 0.0 1.3e-119 399.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 CCF41013.1 - 4.5e-23 81.1 4.1 9.9e-09 33.7 0.1 4.1 1 1 2 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.14 CCF41013.1 - 3.2e-08 33.0 0.0 0.005 15.9 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Peripla_BP_3 PF13377.1 CCF41013.1 - 0.0058 16.6 0.0 1.5 8.7 0.0 2.5 1 1 1 2 2 2 2 Periplasmic binding protein-like domain Anticodon_1 PF08264.8 CCF41013.1 - 0.041 13.6 0.0 0.17 11.6 0.0 1.9 2 0 0 2 2 2 0 Anticodon-binding domain of tRNA NTF2 PF02136.15 CCF41014.1 - 0.013 15.8 0.1 0.05 13.9 0.1 1.8 1 1 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain FAD_binding_3 PF01494.14 CCF41015.1 - 3.2e-21 75.7 0.0 3.8e-20 72.2 0.0 2.1 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF41015.1 - 0.00017 20.6 0.1 0.25 10.2 0.0 2.7 3 0 0 3 3 3 2 FAD dependent oxidoreductase Amino_oxidase PF01593.19 CCF41015.1 - 0.00033 19.8 0.1 0.11 11.5 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox PF00070.22 CCF41015.1 - 0.00098 19.4 1.5 0.0049 17.2 0.0 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF41015.1 - 0.0038 16.1 0.1 2.1 7.1 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Trp_halogenase PF04820.9 CCF41015.1 - 0.024 13.2 0.0 2.5 6.6 0.0 2.5 2 1 1 3 3 3 0 Tryptophan halogenase NAD_binding_8 PF13450.1 CCF41015.1 - 0.035 14.1 0.0 0.13 12.3 0.0 2.0 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF41015.1 - 0.055 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Vps8 PF12816.2 CCF41016.1 - 1.8e-28 99.1 2.0 2.1e-28 98.8 1.4 1.0 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 ResB PF05140.9 CCF41017.1 - 0.052 12.0 0.5 0.067 11.7 0.4 1.1 1 0 0 1 1 1 0 ResB-like family PTH2 PF01981.11 CCF41018.1 - 4.8e-45 151.9 0.4 6.1e-45 151.6 0.2 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 AAA_17 PF13207.1 CCF41019.1 - 6e-06 27.0 0.0 2.4e-05 25.1 0.0 2.2 1 1 0 1 1 1 1 AAA domain CPT PF07931.7 CCF41019.1 - 4.1e-05 23.2 0.0 6.9e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.1 CCF41019.1 - 0.0023 18.2 0.0 0.0059 16.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain PRK PF00485.13 CCF41019.1 - 0.0095 15.5 0.0 0.018 14.6 0.0 1.7 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_28 PF13521.1 CCF41019.1 - 0.036 14.0 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain CoaE PF01121.15 CCF41019.1 - 0.1 12.0 0.0 0.22 10.8 0.0 1.6 1 0 0 1 1 1 0 Dephospho-CoA kinase Glyco_hydro_15 PF00723.16 CCF41020.1 - 1.3e-101 340.3 0.0 1.6e-101 340.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.14 CCF41020.1 - 3.8e-34 116.1 0.7 8.6e-34 115.0 0.5 1.6 1 0 0 1 1 1 1 Starch binding domain SART-1 PF03343.8 CCF41021.1 - 3.5e-158 527.7 60.4 4e-158 527.5 41.8 1.0 1 0 0 1 1 1 1 SART-1 family BNIP3 PF06553.7 CCF41022.1 - 1.9 7.8 8.2 0.37 10.1 0.3 2.2 1 1 0 2 2 2 0 BNIP3 VHS PF00790.14 CCF41023.1 - 1.7e-41 141.1 0.1 1.7e-41 141.1 0.1 2.2 2 0 0 2 2 2 1 VHS domain FYVE PF01363.16 CCF41023.1 - 6.9e-15 54.7 7.9 1.1e-14 54.0 5.5 1.3 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.15 CCF41023.1 - 2.1e-05 23.6 13.8 0.0056 16.1 0.5 3.3 3 0 0 3 3 3 2 Ubiquitin interaction motif zf-DHHC PF01529.15 CCF41023.1 - 0.0015 17.9 1.3 0.0026 17.1 0.9 1.3 1 0 0 1 1 1 1 DHHC palmitoyltransferase HAD_2 PF13419.1 CCF41024.1 - 2.4e-15 57.1 0.0 3.1e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CCF41024.1 - 1.9e-09 38.2 0.0 2.4e-07 31.4 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CCF41024.1 - 1.7e-08 34.0 0.0 2.9e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.2 CCF41024.1 - 6e-05 23.2 0.0 7e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase GHL6 PF14871.1 CCF41024.1 - 0.0091 16.0 0.1 0.035 14.1 0.0 1.9 2 0 0 2 2 2 1 Hypothetical glycosyl hydrolase 6 Hydrolase_6 PF13344.1 CCF41024.1 - 0.017 14.9 0.0 0.53 10.2 0.0 2.8 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase TIP41 PF04176.8 CCF41025.1 - 3.6e-74 247.9 0.7 4.6e-74 247.6 0.5 1.1 1 0 0 1 1 1 1 TIP41-like family DUF3572 PF12096.3 CCF41027.1 - 0.1 12.4 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3572) ABC1 PF03109.11 CCF41028.1 - 2.6e-22 79.0 0.1 7.1e-22 77.6 0.0 1.8 2 0 0 2 2 2 1 ABC1 family APH PF01636.18 CCF41028.1 - 0.0003 20.5 0.0 0.00084 19.1 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.20 CCF41029.1 - 1.2e-35 122.9 0.0 1.5e-35 122.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF41029.1 - 3.4e-27 95.1 0.0 4.1e-27 94.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 CCF41029.1 - 0.00051 19.1 0.0 0.00073 18.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CCF41029.1 - 0.00059 19.6 0.0 0.13 11.9 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 CCF41029.1 - 0.036 13.0 0.0 0.066 12.1 0.0 1.5 2 0 0 2 2 2 0 Kinase-like WD40 PF00400.27 CCF41030.1 - 2.9e-17 61.8 0.8 0.00056 19.6 0.0 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat UDPGT PF00201.13 CCF41031.1 - 0.0014 17.3 0.1 0.0023 16.5 0.0 1.4 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 CCF41031.1 - 0.021 14.5 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain ATG_C PF09333.6 CCF41031.1 - 0.046 13.8 0.0 19 5.5 0.0 2.5 2 0 0 2 2 2 0 ATG C terminal domain NMT1 PF09084.6 CCF41032.1 - 3.5e-77 258.8 0.0 4.2e-77 258.5 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.1 CCF41032.1 - 3.5e-08 33.1 0.1 0.059 12.7 0.0 3.7 2 1 2 4 4 4 3 NMT1-like family DUF4083 PF13314.1 CCF41034.1 - 1.6 8.6 7.0 0.2 11.4 0.4 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4083) DUF373 PF04123.8 CCF41034.1 - 5.2 5.9 8.1 1 8.2 2.8 1.8 1 1 0 2 2 2 0 Domain of unknown function (DUF373) OppC_N PF12911.2 CCF41035.1 - 1.7 8.0 5.8 0.35 10.2 0.1 2.6 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C GDPD PF03009.12 CCF41036.1 - 1.2e-21 77.3 0.0 1.3e-21 77.2 0.0 1.0 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Plus-3 PF03126.13 CCF41037.1 - 4.4e-30 103.9 0.0 9.9e-30 102.7 0.0 1.6 1 0 0 1 1 1 1 Plus-3 domain Glucan_synthase PF02364.10 CCF41039.1 - 0 1461.8 0.2 0 1460.9 0.0 1.5 2 0 0 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 CCF41039.1 - 3.9e-40 136.4 0.2 1.3e-39 134.7 0.1 2.0 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 DUF2452 PF10504.4 CCF41042.1 - 0.024 13.9 0.0 0.039 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2452) GTP_EFTU PF00009.22 CCF41043.1 - 6.9e-38 129.9 0.0 1.3e-37 129.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.6 CCF41043.1 - 3.7e-36 123.0 0.4 7.6e-36 122.0 0.3 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.20 CCF41043.1 - 1e-10 41.5 0.2 2.2e-10 40.4 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 CCF41043.1 - 0.0084 16.0 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 CCF41043.1 - 0.08 12.7 0.0 0.4 10.4 0.0 2.2 3 0 0 3 3 3 0 Dynamin family DUF2890 PF11081.3 CCF41043.1 - 0.13 12.3 1.1 0.21 11.6 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) MARVEL PF01284.18 CCF41045.1 - 0.0023 17.7 8.6 0.019 14.7 4.0 2.4 2 1 0 2 2 2 1 Membrane-associating domain DUF3329 PF11808.3 CCF41045.1 - 0.085 12.9 0.7 0.74 9.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3329) DUF3671 PF12420.3 CCF41045.1 - 0.14 12.1 0.1 0.89 9.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF202 PF02656.10 CCF41045.1 - 5.7 7.2 7.5 1.6 8.9 0.3 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF202) Cpn60_TCP1 PF00118.19 CCF41046.1 - 2.9e-136 454.9 14.4 3.7e-136 454.5 10.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Phage_tail_X PF05489.7 CCF41046.1 - 0.031 13.7 0.0 0.073 12.5 0.0 1.5 1 0 0 1 1 1 0 Phage Tail Protein X DUF3924 PF13062.1 CCF41046.1 - 0.036 13.9 0.1 4 7.3 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3924) AAA PF00004.24 CCF41047.1 - 9.6e-41 139.0 0.0 1.7e-40 138.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CCF41047.1 - 4.3e-06 26.9 0.0 0.00059 19.9 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 CCF41047.1 - 2.1e-05 24.2 0.1 0.00024 20.8 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 CCF41047.1 - 0.00026 20.9 0.0 0.00071 19.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 CCF41047.1 - 0.00028 20.9 0.0 0.0013 18.7 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.8 CCF41047.1 - 0.0019 17.1 0.0 0.0035 16.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_17 PF13207.1 CCF41047.1 - 0.0048 17.7 0.1 0.013 16.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CCF41047.1 - 0.0076 15.9 0.1 0.02 14.6 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 CCF41047.1 - 0.0087 15.1 0.0 0.015 14.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_28 PF13521.1 CCF41047.1 - 0.019 14.9 0.1 0.045 13.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 CCF41047.1 - 0.026 14.4 0.0 0.055 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 CCF41047.1 - 0.036 13.9 0.0 0.064 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 CCF41047.1 - 0.041 13.4 0.0 0.62 9.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 CCF41047.1 - 0.047 13.8 0.0 0.13 12.4 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.6 CCF41047.1 - 0.059 12.9 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 CCF41047.1 - 0.071 12.2 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Sigma54_activ_2 PF14532.1 CCF41047.1 - 0.072 13.1 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.12 CCF41047.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Arch_ATPase PF01637.13 CCF41047.1 - 0.13 11.9 0.6 11 5.6 0.0 2.7 2 1 1 3 3 3 0 Archaeal ATPase Mg_chelatase PF01078.16 CCF41047.1 - 0.13 11.3 0.0 0.31 10.1 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 CCF41047.1 - 0.14 11.5 0.2 0.44 9.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain Cytochrom_C1 PF02167.10 CCF41049.1 - 2.5e-80 269.2 0.0 3.1e-80 268.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.1 CCF41049.1 - 0.0063 16.6 0.0 0.013 15.6 0.0 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III DAHP_synth_1 PF00793.15 CCF41050.1 - 4.4e-78 261.7 0.0 5e-78 261.5 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Sugar_tr PF00083.19 CCF41051.1 - 3.2e-67 227.0 18.4 3.6e-67 226.8 12.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF41051.1 - 7.5e-21 74.2 50.0 1.4e-12 47.0 14.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ABC2_membrane_2 PF12679.2 CCF41051.1 - 0.074 11.8 11.1 0.14 11.0 7.7 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein Fungal_trans PF04082.13 CCF41052.1 - 4.3e-23 81.5 0.0 6.9e-23 80.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41052.1 - 7e-06 25.8 15.8 1.3e-05 25.0 10.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 14-3-3 PF00244.15 CCF41053.1 - 1.2e-113 377.9 0.1 1.7e-113 377.5 0.1 1.1 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.1 CCF41053.1 - 0.021 14.7 1.9 0.61 10.0 0.3 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Ribosomal_60s PF00428.14 CCF41053.1 - 0.024 15.0 7.8 0.057 13.8 2.7 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein CorA PF01544.13 CCF41055.1 - 3.8e-05 22.8 1.0 7.2e-05 21.9 0.0 1.8 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein ICE2 PF08426.5 CCF41057.1 - 2.7e-08 32.8 0.0 3.1e-08 32.6 0.0 1.0 1 0 0 1 1 1 1 ICE2 Abhydrolase_5 PF12695.2 CCF41058.1 - 5.3e-07 29.4 0.0 1e-06 28.5 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF41058.1 - 4.1e-06 26.8 1.5 6.1e-06 26.2 1.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.13 CCF41058.1 - 0.081 12.1 0.0 2.5 7.3 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Fungal_trans PF04082.13 CCF41060.1 - 1.3e-23 83.2 0.5 2e-23 82.6 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41061.1 - 2.3e-08 33.8 9.8 3.7e-08 33.1 6.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Myc_N PF01056.13 CCF41061.1 - 0.0001 21.6 3.7 0.0001 21.6 2.6 2.1 2 0 0 2 2 2 1 Myc amino-terminal region PBP1_TM PF14812.1 CCF41061.1 - 0.76 10.1 14.1 0.055 13.7 4.5 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3245 PF11595.3 CCF41061.1 - 1.4 9.1 6.5 6 7.1 4.5 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) Nucleoplasmin PF03066.10 CCF41061.1 - 3.3 7.2 8.4 5.7 6.4 5.8 1.3 1 0 0 1 1 1 0 Nucleoplasmin FAM176 PF14851.1 CCF41061.1 - 8.9 5.9 7.5 1.6 8.4 2.1 2.0 2 0 0 2 2 2 0 FAM176 family COG6 PF06419.6 CCF41062.1 - 3.8e-222 738.8 3.5 4.4e-222 738.6 2.4 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 RmuC PF02646.11 CCF41062.1 - 0.0034 16.2 2.3 0.0072 15.2 0.4 2.5 3 0 0 3 3 3 1 RmuC family COG2 PF06148.6 CCF41062.1 - 0.28 11.0 3.4 0.27 11.1 0.2 2.5 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Ribosomal_L1 PF00687.16 CCF41063.1 - 3.6e-24 85.3 0.1 4.8e-24 84.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family tRNA-synt_1c PF00749.16 CCF41064.1 - 9.4e-101 336.5 0.1 1.3e-100 336.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 CCF41064.1 - 2.6e-39 134.6 0.0 5.2e-39 133.6 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_1e PF01406.14 CCF41064.1 - 0.0067 15.5 0.2 0.018 14.1 0.1 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain 2-Hacid_dh_C PF02826.14 CCF41065.1 - 7.3e-37 126.2 0.0 1e-36 125.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 CCF41065.1 - 4.4e-09 35.9 0.0 6.1e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 CCF41065.1 - 3.1e-06 27.1 0.0 5.2e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase SPC12 PF06645.8 CCF41066.1 - 4.3 7.2 10.3 0.62 9.9 0.9 3.5 3 0 0 3 3 3 0 Microsomal signal peptidase 12 kDa subunit (SPC12) ADH_N PF08240.7 CCF41068.1 - 0.00063 19.4 0.0 0.0012 18.5 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF41068.1 - 0.003 17.0 0.1 0.0064 16.0 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.7 CCF41071.1 - 2.9e-17 62.9 0.0 9.9e-17 61.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF41071.1 - 5.4e-11 42.8 0.0 1e-10 41.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF41071.1 - 1.1e-09 38.1 0.0 2e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF41071.1 - 1.8e-09 37.3 0.0 3e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF41071.1 - 1.6e-07 31.9 0.0 3.9e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF41071.1 - 6.2e-06 25.4 0.0 0.00013 21.1 0.0 2.7 3 0 0 3 3 3 1 ubiE/COQ5 methyltransferase family Methyltransf_24 PF13578.1 CCF41071.1 - 0.0049 17.6 0.0 0.021 15.6 0.0 2.1 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF41071.1 - 0.012 15.6 0.0 0.03 14.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.6 CCF41071.1 - 0.026 13.9 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) DUF1803 PF08820.5 CCF41071.1 - 0.079 12.6 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1803) RrnaAD PF00398.15 CCF41071.1 - 0.17 10.8 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PNGaseA PF12222.3 CCF41072.1 - 7.3e-128 427.0 0.0 1e-127 426.5 0.0 1.2 1 0 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A Pkinase PF00069.20 CCF41073.1 - 6.4e-28 97.6 0.0 1e-27 96.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF41073.1 - 2.5e-07 30.0 0.0 0.00039 19.5 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Glyco_hydro_10 PF00331.15 CCF41074.1 - 2.8e-100 335.4 0.1 3.2e-100 335.2 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Glyco_hydro_42 PF02449.10 CCF41074.1 - 0.07 12.2 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Beta-galactosidase HTH_42 PF06224.7 CCF41074.1 - 0.11 11.8 0.1 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain PhyH PF05721.8 CCF41076.1 - 1.8e-11 44.4 0.1 3.9e-11 43.3 0.1 1.5 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.7 CCF41076.1 - 1.1e-07 30.7 0.1 3e-05 22.7 0.1 2.7 2 1 0 2 2 2 2 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_3 PF13640.1 CCF41076.1 - 0.012 16.1 0.0 0.029 14.8 0.0 1.6 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Fungal_trans PF04082.13 CCF41077.1 - 3.2e-11 42.6 0.0 1e-10 40.9 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 CCF41079.1 - 3.2e-23 80.6 22.7 3.1e-06 27.1 0.5 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CCF41079.1 - 2.5e-21 74.8 26.3 7.7e-09 35.4 0.8 5.0 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.1 CCF41079.1 - 5.5e-18 63.8 20.4 3.8e-05 23.7 0.4 4.6 4 0 0 4 4 4 4 C2H2-type zinc finger zf-met PF12874.2 CCF41079.1 - 0.00045 20.3 13.8 1.4 9.1 0.1 5.3 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 CCF41079.1 - 0.00073 19.6 7.5 0.28 11.3 0.1 4.3 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 CCF41079.1 - 0.1 12.5 7.0 0.28 11.1 0.2 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger zf-LYAR PF08790.6 CCF41079.1 - 0.63 9.7 7.2 5.5 6.7 0.1 3.7 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger Zn-ribbon_8 PF09723.5 CCF41079.1 - 2.3 8.2 6.8 13 5.8 0.1 4.0 4 0 0 4 4 4 0 Zinc ribbon domain DUF1752 PF08550.5 CCF41080.1 - 1.6e-10 40.3 4.1 4.5e-10 38.9 2.8 1.8 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) RRM_1 PF00076.17 CCF41081.1 - 2.4e-16 59.0 0.0 5.6e-13 48.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF41081.1 - 3.1e-09 36.6 0.0 1.2e-06 28.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nab6_mRNP_bdg PF10567.4 CCF41081.1 - 0.054 12.4 0.0 0.075 12.0 0.0 1.1 1 0 0 1 1 1 0 RNA-recognition motif Cu-oxidase_3 PF07732.10 CCF41082.1 - 6.9e-37 125.7 0.8 2.2e-36 124.1 0.0 2.3 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 CCF41082.1 - 9.4e-28 96.4 5.6 4.1e-21 74.9 0.2 4.2 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 CCF41082.1 - 2.2e-13 50.3 0.9 1.2e-11 44.8 0.1 2.7 2 1 0 2 2 2 1 Multicopper oxidase NmrA PF05368.8 CCF41083.1 - 5e-14 52.1 0.0 2.1e-13 50.0 0.0 1.7 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF41083.1 - 2.1e-12 47.4 0.0 3.9e-12 46.5 0.0 1.5 2 0 0 2 2 2 1 NADH(P)-binding Epimerase PF01370.16 CCF41083.1 - 0.00075 18.9 0.1 0.0024 17.3 0.0 1.8 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_2 PF03446.10 CCF41083.1 - 0.0018 18.1 0.0 0.012 15.4 0.0 2.1 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_7 PF13241.1 CCF41083.1 - 0.015 15.5 0.0 0.032 14.4 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding F420_oxidored PF03807.12 CCF41083.1 - 0.017 15.5 0.0 0.031 14.6 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 CCF41083.1 - 0.061 12.4 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_4 PF01565.18 CCF41084.1 - 3.4e-20 71.9 0.2 5.3e-20 71.3 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain ketoacyl-synt PF00109.21 CCF41085.1 - 2.9e-66 223.5 1.0 4.7e-66 222.8 0.1 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 CCF41085.1 - 8.1e-46 156.8 2.3 1.4e-45 156.0 1.6 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.17 CCF41085.1 - 6.7e-32 109.8 5.0 8.9e-32 109.4 2.1 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.15 CCF41085.1 - 1e-27 97.8 0.0 3.1e-27 96.3 0.0 1.9 1 0 0 1 1 1 1 Thioesterase domain PS-DH PF14765.1 CCF41085.1 - 1.6e-12 47.1 0.0 3.3e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase PP-binding PF00550.20 CCF41085.1 - 2.2e-10 40.6 0.4 6.1e-10 39.2 0.1 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site Thiolase_N PF00108.18 CCF41085.1 - 2e-06 26.9 0.0 5.1e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain Abhydrolase_6 PF12697.2 CCF41085.1 - 4e-06 26.8 1.1 0.0011 18.8 0.0 2.6 2 0 0 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF41085.1 - 0.00017 21.3 0.1 0.23 11.1 0.0 2.6 2 0 0 2 2 2 2 Alpha/beta hydrolase family ACP_syn_III PF08545.5 CCF41085.1 - 0.04 13.5 0.3 0.53 9.9 0.0 2.9 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF2974 PF11187.3 CCF41085.1 - 0.1 11.9 0.2 1.5 8.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) DUF1992 PF09350.5 CCF41086.1 - 2.3e-24 85.0 0.2 5.9e-24 83.6 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) TRCF PF03461.10 CCF41086.1 - 0.0089 15.9 0.1 0.21 11.5 0.0 2.4 2 0 0 2 2 2 1 TRCF domain Synaphin PF05835.7 CCF41086.1 - 0.06 13.5 0.1 0.06 13.5 0.0 2.9 4 0 0 4 4 4 0 Synaphin protein Alg14 PF08660.6 CCF41086.1 - 0.22 11.4 0.0 0.38 10.7 0.0 1.4 1 0 0 1 1 1 0 Oligosaccharide biosynthesis protein Alg14 like adh_short PF00106.20 CCF41087.1 - 1.1e-20 74.2 0.2 1.4e-20 73.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF41087.1 - 1e-08 35.2 0.0 1.2e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 CCF41087.1 - 0.00013 22.0 0.2 0.00019 21.4 0.1 1.4 1 1 0 1 1 1 1 NADH(P)-binding KR PF08659.5 CCF41087.1 - 0.0002 21.0 0.3 0.00039 20.1 0.2 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF41087.1 - 0.012 15.1 0.1 0.024 14.0 0.1 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Saccharop_dh PF03435.13 CCF41087.1 - 0.023 13.7 0.3 0.034 13.1 0.2 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase HHH_5 PF14520.1 CCF41087.1 - 0.073 13.2 0.4 0.16 12.1 0.3 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix domain Eno-Rase_NADH_b PF12242.3 CCF41087.1 - 0.11 12.3 0.1 0.3 10.8 0.1 1.7 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase adh_short PF00106.20 CCF41088.1 - 1.3e-21 77.2 1.1 1.7e-21 76.8 0.7 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF41088.1 - 4.6e-19 69.1 0.0 6.8e-19 68.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF41088.1 - 2.5e-08 33.7 0.8 9.1e-08 31.9 0.5 1.8 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 CCF41088.1 - 0.022 13.6 0.0 0.033 13.0 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.16 CCF41088.1 - 0.042 13.2 0.1 0.22 10.9 0.1 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family ABC_tran PF00005.22 CCF41090.1 - 5.2e-08 33.2 0.0 2.6e-07 31.0 0.0 1.9 2 0 0 2 2 2 1 ABC transporter ALIX_LYPXL_bnd PF13949.1 CCF41090.1 - 0.00095 18.2 0.1 0.00095 18.2 0.0 1.6 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV End3 PF12761.2 CCF41090.1 - 0.048 13.2 0.6 0.074 12.6 0.4 1.4 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 DUF498 PF04430.9 CCF41090.1 - 0.076 12.5 0.0 0.19 11.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF498/DUF598) Mei5 PF10376.4 CCF41090.1 - 0.096 12.1 1.7 0.16 11.5 1.2 1.3 1 0 0 1 1 1 0 Double-strand recombination repair protein THOC7 PF05615.8 CCF41090.1 - 0.92 9.7 7.6 0.39 10.9 3.3 1.8 2 0 0 2 2 2 0 Tho complex subunit 7 Epiglycanin_C PF14654.1 CCF41091.1 - 0.047 13.7 0.0 0.077 13.0 0.0 1.4 1 0 0 1 1 1 0 Mucin, catalytic, TM and cytoplasmic tail region AAA PF00004.24 CCF41094.1 - 3.7e-17 62.7 0.0 2.4e-08 34.2 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 CCF41094.1 - 0.00039 19.8 0.2 0.0016 17.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 CCF41094.1 - 0.00043 21.0 1.2 0.0083 16.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CCF41094.1 - 0.00088 19.3 0.1 0.0038 17.2 0.0 1.9 1 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.9 CCF41094.1 - 0.001 18.7 0.0 0.0052 16.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF4207 PF13904.1 CCF41094.1 - 0.0011 18.3 18.5 0.0016 17.9 12.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) RuvB_N PF05496.7 CCF41094.1 - 0.0014 17.6 0.0 0.0042 16.1 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus ARGLU PF15346.1 CCF41094.1 - 0.0019 18.0 25.2 0.003 17.3 17.5 1.3 1 0 0 1 1 1 1 Arginine and glutamate-rich 1 AAA_19 PF13245.1 CCF41094.1 - 0.0046 16.6 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain DDRGK PF09756.4 CCF41094.1 - 0.0054 16.1 30.9 0.8 9.0 0.0 2.4 2 0 0 2 2 2 2 DDRGK domain KaiC PF06745.8 CCF41094.1 - 0.0093 15.0 0.0 0.04 13.0 0.0 2.1 3 0 0 3 3 3 1 KaiC IstB_IS21 PF01695.12 CCF41094.1 - 0.04 13.3 0.0 0.087 12.2 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_29 PF13555.1 CCF41094.1 - 0.043 13.3 0.0 0.086 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.1 CCF41094.1 - 0.066 13.1 0.5 0.4 10.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain U79_P34 PF03064.11 CCF41094.1 - 0.085 12.3 20.0 0.15 11.5 13.9 1.4 1 0 0 1 1 1 0 HSV U79 / HCMV P34 AAA_18 PF13238.1 CCF41094.1 - 0.14 12.4 0.0 0.14 12.4 0.0 3.3 2 1 0 2 2 1 0 AAA domain MIP-T3 PF10243.4 CCF41094.1 - 0.14 10.6 30.5 0.19 10.1 21.1 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF755 PF05501.6 CCF41094.1 - 0.16 12.0 20.4 0.29 11.1 14.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Borrelia_P83 PF05262.6 CCF41094.1 - 0.18 10.0 21.2 0.24 9.6 14.7 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein GAGA_bind PF06217.7 CCF41094.1 - 0.19 11.6 9.8 0.26 11.2 6.8 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family CheZ PF04344.8 CCF41094.1 - 0.33 10.5 0.0 0.33 10.5 0.0 2.6 1 1 1 2 2 1 0 Chemotaxis phosphatase, CheZ TFIIF_alpha PF05793.7 CCF41094.1 - 0.71 8.1 29.7 0.99 7.6 20.6 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF3807 PF12720.2 CCF41094.1 - 1.5 8.9 21.9 2.8 8.0 15.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) RR_TM4-6 PF06459.7 CCF41094.1 - 1.8 8.3 15.8 2.7 7.8 11.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spore_coat_CotO PF14153.1 CCF41094.1 - 2 7.8 20.2 3.5 7.0 14.0 1.4 1 0 0 1 1 1 0 Spore coat protein CotO RNA_polI_A34 PF08208.6 CCF41094.1 - 2.2 7.9 26.0 3.9 7.1 18.0 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 NARP1 PF12569.3 CCF41094.1 - 3.5 6.2 20.5 4.9 5.7 14.2 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF1510 PF07423.6 CCF41094.1 - 4.8 6.4 24.9 7.8 5.8 17.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) PBP_sp32 PF07222.7 CCF41094.1 - 5.1 6.1 12.5 7.9 5.5 8.7 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Ycf1 PF05758.7 CCF41094.1 - 5.7 4.5 13.6 7.3 4.1 9.4 1.1 1 0 0 1 1 1 0 Ycf1 Vfa1 PF08432.5 CCF41094.1 - 6.9 6.6 24.4 12 5.9 16.9 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DDHD PF02862.12 CCF41094.1 - 7.9 6.2 12.1 13 5.5 8.4 1.4 1 0 0 1 1 1 0 DDHD domain DUF1680 PF07944.7 CCF41095.1 - 1.4e-40 139.0 0.0 4.5e-38 130.7 0.0 2.0 1 1 1 2 2 2 2 Putative glycosyl hydrolase of unknown function (DUF1680) Pertactin PF03212.9 CCF41095.1 - 0.027 14.1 0.1 0.089 12.5 0.0 1.8 1 1 0 1 1 1 0 Pertactin Oxidored_FMN PF00724.15 CCF41096.1 - 0.0064 15.5 0.0 0.0082 15.1 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.12 CCF41096.1 - 0.046 12.5 0.0 0.046 12.5 0.0 1.1 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) Fungal_trans PF04082.13 CCF41098.1 - 1.7e-18 66.4 0.0 3.4e-18 65.4 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41098.1 - 3.6e-07 29.9 17.5 6.4e-07 29.1 12.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CCDC142 PF14923.1 CCF41098.1 - 0.024 12.9 0.3 0.038 12.2 0.2 1.2 1 0 0 1 1 1 0 Coiled-coil protein 142 WD40 PF00400.27 CCF41099.1 - 1.7e-29 100.6 0.4 5.1e-10 38.8 0.1 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.3 CCF41099.1 - 0.00062 18.0 0.0 0.00076 17.7 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 PQQ_2 PF13360.1 CCF41099.1 - 0.0012 18.3 0.5 0.51 9.7 0.1 2.4 1 1 1 2 2 2 2 PQQ-like domain eIF2A PF08662.6 CCF41099.1 - 0.0018 18.0 0.1 0.46 10.1 0.0 2.6 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 CCF41099.1 - 0.0032 16.2 0.0 0.046 12.4 0.0 2.4 1 1 1 2 2 2 1 Nup133 N terminal like Coatomer_WDAD PF04053.9 CCF41099.1 - 0.0046 15.8 0.1 0.14 10.8 0.0 2.0 1 1 1 2 2 2 1 Coatomer WD associated region adh_short PF00106.20 CCF41100.1 - 2.7e-12 46.9 0.1 4.3e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF41100.1 - 8.3e-06 25.7 0.0 9.9e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF41100.1 - 0.00011 21.8 0.1 0.00017 21.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Kinesin PF00225.18 CCF41101.1 - 2.4e-45 154.6 0.1 2.4e-45 154.6 0.1 1.5 2 0 0 2 2 2 1 Kinesin motor domain Bac_DnaA PF00308.13 CCF41101.1 - 0.012 15.3 0.0 0.028 14.0 0.0 1.7 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_22 PF13401.1 CCF41101.1 - 0.044 13.9 0.0 0.25 11.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF1768 PF08719.6 CCF41102.1 - 2.3e-49 167.1 0.0 3.2e-49 166.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Tim44 PF04280.10 CCF41103.1 - 6.7e-35 120.2 0.1 1.9e-34 118.7 0.0 1.8 2 0 0 2 2 2 1 Tim44-like domain Ribosomal_S11 PF00411.14 CCF41104.1 - 9.2e-10 38.6 0.0 1.5e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S11 Peptidase_C97 PF05903.9 CCF41105.1 - 5e-34 117.2 0.0 6.5e-34 116.8 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.8 CCF41105.1 - 0.00075 19.4 0.0 0.0012 18.7 0.0 1.3 1 0 0 1 1 1 1 Lecithin retinol acyltransferase YchF-GTPase_C PF06071.8 CCF41106.1 - 3.3e-34 116.5 0.2 9.5e-34 115.0 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 CCF41106.1 - 9.5e-13 48.1 0.0 4.5e-12 45.9 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.16 CCF41106.1 - 0.00028 20.6 0.0 0.00073 19.3 0.0 1.7 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.13 CCF41106.1 - 0.00047 19.4 0.0 0.00093 18.5 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B BetaGal_dom3 PF13363.1 CCF41106.1 - 0.0042 16.4 0.0 0.009 15.3 0.0 1.5 1 0 0 1 1 1 1 Beta-galactosidase, domain 3 MobB PF03205.9 CCF41106.1 - 0.025 14.2 1.2 4 7.1 0.1 2.8 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 CCF41106.1 - 0.036 13.9 0.0 0.095 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain MsyB PF13984.1 CCF41106.1 - 0.047 13.7 0.1 0.45 10.5 0.0 2.2 1 1 1 2 2 2 0 MsyB protein AAA_18 PF13238.1 CCF41106.1 - 0.06 13.6 0.3 31 4.8 0.6 3.0 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.1 CCF41106.1 - 0.064 13.5 3.3 0.31 11.3 2.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.1 CCF41106.1 - 0.097 13.4 0.0 0.49 11.2 0.0 2.2 2 1 0 2 2 2 0 AAA domain TPR_19 PF14559.1 CCF41107.1 - 0.00017 21.8 2.0 0.99 9.7 0.1 3.4 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 CCF41107.1 - 0.022 15.4 3.7 0.25 12.0 0.3 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat AphA_like PF14557.1 CCF41107.1 - 0.051 13.1 0.1 9.4 5.7 0.0 2.8 1 1 1 2 2 2 0 Putative AphA-like transcriptional regulator HemY_N PF07219.8 CCF41107.1 - 0.053 13.0 0.3 0.11 12.0 0.2 1.5 1 0 0 1 1 1 0 HemY protein N-terminus TPR_4 PF07721.9 CCF41107.1 - 0.79 10.3 8.4 0.67 10.5 0.5 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Prismane PF03063.15 CCF41111.1 - 0.19 10.0 0.2 0.26 9.6 0.1 1.1 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family O-antigen_lig PF13425.1 CCF41111.1 - 6.6 6.7 15.3 0.02 14.8 1.0 3.1 3 1 0 3 3 3 0 O-antigen ligase like membrane protein FAT PF02259.18 CCF41112.1 - 2.9e-74 250.1 5.4 5.2e-74 249.3 3.8 1.4 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.22 CCF41112.1 - 1.1e-26 93.8 0.2 1.1e-26 93.8 0.2 2.2 3 0 0 3 3 3 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.15 CCF41112.1 - 9.8e-10 37.7 0.2 2e-09 36.7 0.2 1.5 1 0 0 1 1 1 1 FATC domain AAA_32 PF13654.1 CCF41112.1 - 0.028 13.1 0.1 0.046 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain TPR_8 PF13181.1 CCF41112.1 - 0.03 14.0 0.4 0.12 12.2 0.3 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat HET PF06985.6 CCF41113.1 - 2.2e-31 108.8 0.1 4.6e-31 107.8 0.1 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF624 PF04854.9 CCF41114.1 - 1.6 8.6 6.2 0.49 10.3 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function, DUF624 Fungal_trans PF04082.13 CCF41115.1 - 6.3e-43 146.5 0.0 1e-42 145.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41115.1 - 2.8e-08 33.5 6.7 6e-08 32.4 4.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_4 PF08386.5 CCF41116.1 - 5.2e-20 71.2 0.0 1.7e-19 69.5 0.0 1.9 2 0 0 2 2 2 1 TAP-like protein Abhydrolase_1 PF00561.15 CCF41116.1 - 2.2e-14 53.5 0.0 8.1e-13 48.4 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF41116.1 - 7.9e-06 25.9 0.1 6.7e-05 22.8 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF41116.1 - 0.0077 16.0 0.0 0.14 11.8 0.0 2.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family RuBisCO_large PF00016.15 CCF41116.1 - 0.12 11.2 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, catalytic domain Z1 PF10593.4 CCF41117.1 - 0.053 12.7 4.5 0.11 11.6 3.1 1.5 1 0 0 1 1 1 0 Z1 domain UBN2_3 PF14244.1 CCF41117.1 - 0.37 10.3 4.0 2.5 7.6 0.0 2.5 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type Herpes_UL6 PF01763.11 CCF41117.1 - 0.55 8.3 8.5 1.1 7.3 5.9 1.4 1 0 0 1 1 1 0 Herpesvirus UL6 like ERM PF00769.14 CCF41117.1 - 0.88 9.0 36.9 3 7.3 2.1 2.3 1 1 1 2 2 2 0 Ezrin/radixin/moesin family IncA PF04156.9 CCF41117.1 - 1.5 8.4 34.6 0.082 12.4 12.3 3.1 3 0 0 3 3 3 0 IncA protein DUF4615 PF15393.1 CCF41117.1 - 1.6 8.9 10.5 0.16 12.1 3.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4615) DUF4557 PF15101.1 CCF41117.1 - 2.6 7.8 6.9 5.1 6.8 4.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) DUF342 PF03961.8 CCF41117.1 - 2.9 6.1 16.2 0.26 9.6 7.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF342) Fib_alpha PF08702.5 CCF41117.1 - 3.8 7.6 17.2 23 5.0 5.8 3.2 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family HTH_39 PF14090.1 CCF41118.1 - 0.047 13.1 0.4 0.12 11.8 0.3 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain F-box-like PF12937.2 CCF41119.1 - 2.4e-08 33.5 0.2 2.4e-08 33.5 0.1 2.4 3 0 0 3 3 3 1 F-box-like F-box PF00646.28 CCF41119.1 - 0.37 10.4 5.4 2.2 8.0 0.2 3.6 4 0 0 4 4 4 0 F-box domain GCR1_C PF12550.3 CCF41120.1 - 3.4e-16 58.8 0.2 9.1e-16 57.5 0.1 1.7 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes FMO-like PF00743.14 CCF41120.1 - 3.3e-05 22.3 0.0 5.3e-05 21.6 0.0 1.3 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Oxidored_FMN PF00724.15 CCF41120.1 - 6.1e-05 22.1 0.2 0.11 11.5 0.0 2.3 1 1 1 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family SBP_bac_6 PF13343.1 CCF41121.1 - 2.3e-09 36.9 1.0 2.7e-09 36.7 0.7 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.1 CCF41121.1 - 2.2e-06 27.4 0.1 3.5e-06 26.8 0.1 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.20 CCF41121.1 - 0.011 15.4 0.7 0.021 14.5 0.4 1.4 1 1 0 1 1 1 0 Bacterial extracellular solute-binding protein MFS_1 PF07690.11 CCF41122.1 - 6e-18 64.6 57.9 1.1e-10 40.8 29.7 4.1 1 1 2 3 3 3 3 Major Facilitator Superfamily dCMP_cyt_deam_1 PF00383.17 CCF41123.1 - 5.1e-06 26.0 0.1 6.4e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region BTB PF00651.26 CCF41125.1 - 7.5e-07 29.1 0.5 0.00021 21.2 0.0 3.0 2 1 1 3 3 3 2 BTB/POZ domain Tetraspannin PF00335.15 CCF41127.1 - 4.2e-10 39.2 7.0 5.5e-10 38.8 4.8 1.1 1 0 0 1 1 1 1 Tetraspanin family FxsA PF04186.8 CCF41127.1 - 1.9 8.0 7.4 14 5.3 5.2 2.2 1 1 1 2 2 2 0 FxsA cytoplasmic membrane protein Competence PF03772.11 CCF41127.1 - 2.1 7.3 10.6 0.11 11.5 3.4 1.7 2 1 0 2 2 2 0 Competence protein FAD_binding_3 PF01494.14 CCF41128.1 - 8.1e-13 48.1 0.5 1.8e-11 43.7 0.0 2.3 2 1 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.1 CCF41128.1 - 0.0012 18.8 0.0 0.0028 17.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF41128.1 - 0.0014 17.5 0.0 0.0039 16.1 0.0 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase SE PF08491.5 CCF41128.1 - 0.0022 16.8 0.0 1 8.0 0.0 2.3 2 0 0 2 2 2 2 Squalene epoxidase NAD_binding_9 PF13454.1 CCF41128.1 - 0.0049 16.6 0.1 0.51 10.0 0.0 3.0 3 1 1 4 4 4 1 FAD-NAD(P)-binding Trp_halogenase PF04820.9 CCF41128.1 - 0.026 13.1 0.0 0.57 8.7 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase Opy2 PF09463.5 CCF41129.1 - 8.3e-07 28.9 17.6 1.6e-06 28.1 12.2 1.5 1 0 0 1 1 1 1 Opy2 protein Syndecan PF01034.15 CCF41129.1 - 0.16 11.6 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain DUF2797 PF10977.3 CCF41129.1 - 0.48 10.0 3.3 0.81 9.2 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) DASH_Dad4 PF08650.5 CCF41130.1 - 9e-29 99.2 6.7 9.7e-29 99.0 4.6 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 GM_CSF PF01109.12 CCF41130.1 - 0.064 13.2 0.7 0.073 13.0 0.5 1.1 1 0 0 1 1 1 0 Granulocyte-macrophage colony-stimulating factor Biotin_carb_C PF02785.14 CCF41130.1 - 0.079 12.9 0.0 0.088 12.7 0.0 1.1 1 0 0 1 1 1 0 Biotin carboxylase C-terminal domain DASH_Dad1 PF08649.5 CCF41130.1 - 0.17 11.5 3.1 0.22 11.2 2.1 1.2 1 0 0 1 1 1 0 DASH complex subunit Dad1 Actin PF00022.14 CCF41131.1 - 6.8e-59 199.2 0.0 9e-35 119.8 0.0 2.1 2 0 0 2 2 2 2 Actin ATG2_CAD PF13329.1 CCF41132.1 - 3.3e-53 179.4 1.8 1.9e-52 176.9 0.8 2.5 3 0 0 3 3 3 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.6 CCF41132.1 - 2.1e-30 104.7 0.0 1.5e-29 102.0 0.1 2.5 3 0 0 3 3 3 1 ATG C terminal domain Glyco_hydro_114 PF03537.8 CCF41132.1 - 0.064 13.0 0.1 0.27 11.0 0.0 2.1 2 0 0 2 2 2 0 Glycoside-hydrolase family GH114 DNA_pol_E_B PF04042.11 CCF41133.1 - 5.8e-62 208.6 0.0 7.6e-62 208.2 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B TPR_11 PF13414.1 CCF41134.1 - 1.7e-11 43.5 2.0 1.7e-11 43.5 1.4 1.6 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 CCF41134.1 - 3.9e-05 23.2 1.3 0.021 14.7 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 CCF41134.1 - 0.00026 20.8 1.2 0.00045 20.1 0.8 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.23 CCF41134.1 - 0.0012 18.3 0.2 0.09 12.4 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 CCF41134.1 - 0.0019 18.3 1.3 0.0031 17.5 0.9 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 CCF41134.1 - 0.01 16.3 0.2 0.53 11.0 0.0 2.8 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 CCF41134.1 - 0.036 13.8 2.9 1.9 8.4 0.0 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat BRCT_assoc PF12820.2 CCF41134.1 - 0.34 10.6 4.4 0.14 11.9 0.3 2.0 1 1 1 2 2 2 0 Serine-rich domain associated with BRCT HAD_2 PF13419.1 CCF41135.1 - 8.8e-14 52.0 0.0 5.1e-06 26.8 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CCF41135.1 - 8e-06 25.4 0.0 1.4e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 CCF41135.1 - 8.4e-06 26.3 0.0 0.001 19.5 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase SPOC PF07744.8 CCF41136.1 - 1.8e-20 73.6 0.0 3.6e-20 72.6 0.0 1.6 1 0 0 1 1 1 1 SPOC domain TFIIS_M PF07500.9 CCF41136.1 - 3.6e-13 49.6 0.7 6.2e-13 48.8 0.5 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain Med7 PF05983.6 CCF41138.1 - 2.9e-48 163.7 0.0 3.5e-48 163.4 0.0 1.1 1 0 0 1 1 1 1 MED7 protein DUF1677 PF07911.8 CCF41139.1 - 0.026 14.7 0.1 0.026 14.7 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1677) zf-met PF12874.2 CCF41139.1 - 0.033 14.3 0.4 0.054 13.7 0.3 1.3 1 0 0 1 1 1 0 Zinc-finger of C2H2 type AAA_23 PF13476.1 CCF41139.1 - 2.3 8.5 5.9 3.8 7.7 4.1 1.3 1 0 0 1 1 1 0 AAA domain IncA PF04156.9 CCF41139.1 - 4.2 6.9 9.1 1 8.9 4.2 1.5 2 0 0 2 2 2 0 IncA protein LAMTOR PF15454.1 CCF41141.1 - 2e-19 69.6 0.0 2.9e-19 69.1 0.0 1.2 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Toxin_60 PF15607.1 CCF41141.1 - 0.05 13.6 0.0 0.19 11.8 0.0 1.8 2 0 0 2 2 2 0 Putative toxin 60 Vps5 PF09325.5 CCF41142.1 - 0.033 13.4 0.5 0.04 13.1 0.4 1.1 1 0 0 1 1 1 0 Vps5 C terminal like MFS_1 PF07690.11 CCF41144.1 - 3.3e-26 91.8 40.2 2e-22 79.4 24.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TPR_11 PF13414.1 CCF41145.1 - 9.1e-40 134.1 23.4 3.1e-07 29.9 0.1 10.7 8 1 4 12 12 12 8 TPR repeat TPR_16 PF13432.1 CCF41145.1 - 2.5e-32 110.7 23.4 1.5e-06 28.6 0.0 11.1 9 3 2 12 12 11 5 Tetratricopeptide repeat TPR_14 PF13428.1 CCF41145.1 - 8.7e-31 103.6 12.8 0.00035 20.9 0.1 13.4 8 5 6 14 14 14 6 Tetratricopeptide repeat TPR_2 PF07719.12 CCF41145.1 - 3.7e-30 101.3 30.1 4.7e-06 26.1 0.0 14.0 15 0 0 15 15 14 8 Tetratricopeptide repeat TPR_1 PF00515.23 CCF41145.1 - 4.9e-30 101.8 18.8 2e-07 30.3 0.0 12.4 13 0 0 13 13 12 7 Tetratricopeptide repeat TPR_19 PF14559.1 CCF41145.1 - 1.9e-25 88.9 16.5 5.3e-07 29.8 0.3 9.7 8 2 1 9 9 9 5 Tetratricopeptide repeat TPR_12 PF13424.1 CCF41145.1 - 1.3e-24 85.9 31.9 9.8e-05 22.2 0.0 10.6 10 3 2 13 13 11 7 Tetratricopeptide repeat TPR_17 PF13431.1 CCF41145.1 - 2.9e-24 83.1 5.6 0.074 13.2 0.0 12.6 12 0 0 12 12 12 3 Tetratricopeptide repeat TPR_7 PF13176.1 CCF41145.1 - 6.2e-15 53.7 18.9 0.00019 20.9 0.0 11.9 13 1 1 14 14 14 3 Tetratricopeptide repeat TPR_8 PF13181.1 CCF41145.1 - 9.5e-15 53.2 22.8 0.00022 20.7 0.0 11.2 11 1 1 12 12 12 4 Tetratricopeptide repeat TPR_9 PF13371.1 CCF41145.1 - 3e-11 42.9 5.6 0.01 15.6 0.0 7.0 6 1 0 6 6 5 2 Tetratricopeptide repeat Apc3 PF12895.2 CCF41145.1 - 5.7e-11 42.4 14.6 0.017 15.2 0.0 7.7 6 2 1 8 8 8 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 CCF41145.1 - 9.3e-11 41.4 21.5 0.037 14.4 0.0 13.2 15 0 0 15 15 15 2 Tetratricopeptide repeat TPR_20 PF14561.1 CCF41145.1 - 1.4e-07 31.5 3.0 0.78 9.8 0.0 5.3 4 0 0 4 4 4 2 Tetratricopeptide repeat Coatomer_WDAD PF04053.9 CCF41145.1 - 0.0057 15.5 0.0 0.015 14.1 0.0 1.6 1 0 0 1 1 1 1 Coatomer WD associated region DUF2989 PF11207.3 CCF41145.1 - 0.0082 15.6 2.4 1 8.7 0.1 3.5 3 0 0 3 3 3 1 Protein of unknown function (DUF2989) DUF445 PF04286.7 CCF41147.1 - 0.038 13.5 17.2 0.16 11.4 11.9 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF445) PA26 PF04636.8 CCF41147.1 - 3.5 6.1 12.1 0.6 8.7 5.7 1.7 1 1 1 2 2 2 0 PA26 p53-induced protein (sestrin) GFA PF04828.9 CCF41148.1 - 0.00033 20.5 0.1 0.00033 20.5 0.0 1.7 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme CN_hydrolase PF00795.17 CCF41149.1 - 5.7e-31 107.3 0.1 7.5e-31 106.9 0.1 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase RNase_T PF00929.19 CCF41150.1 - 1.8e-10 41.3 0.0 2.5e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.15 CCF41150.1 - 2.1e-05 24.0 0.0 3e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease HET PF06985.6 CCF41151.1 - 2.4e-21 76.3 4.9 3.7e-18 66.0 0.4 2.3 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) PepX_C PF08530.5 CCF41154.1 - 3.9e-23 82.5 1.1 4.2e-21 75.8 0.8 2.1 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain TPR_11 PF13414.1 CCF41155.1 - 2.4e-13 49.5 0.7 1.8e-09 37.1 0.4 2.1 1 1 1 2 2 2 2 TPR repeat TPR_14 PF13428.1 CCF41155.1 - 9.3e-11 41.3 0.2 4.7e-05 23.6 0.2 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 CCF41155.1 - 3.5e-10 38.9 0.1 1e-05 25.0 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 CCF41155.1 - 1e-09 37.5 0.3 4.1e-06 26.1 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 CCF41155.1 - 2.5e-09 36.2 0.2 0.0013 18.4 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 CCF41155.1 - 1.3e-07 32.0 0.2 1.2e-05 25.8 0.2 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 CCF41155.1 - 6.8e-07 29.1 0.4 1.2e-06 28.3 0.3 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.1 CCF41155.1 - 8e-06 25.6 0.4 0.032 14.4 0.0 3.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 CCF41155.1 - 3e-05 24.2 0.1 5.6e-05 23.3 0.1 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.1 CCF41155.1 - 0.00011 21.7 0.1 0.4 10.5 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.1 CCF41155.1 - 0.00089 19.5 0.2 0.042 14.3 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.1 CCF41155.1 - 0.0015 18.3 0.5 0.067 13.1 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.1 CCF41155.1 - 0.0027 16.8 0.3 0.0048 15.9 0.2 1.4 1 1 0 1 1 1 1 Tetratricopeptide repeat Apc3 PF12895.2 CCF41155.1 - 0.0059 16.7 0.0 0.0084 16.2 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.1 CCF41155.1 - 0.009 15.8 0.2 6.4 6.7 0.0 2.6 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.1 CCF41155.1 - 0.016 15.0 0.2 0.049 13.4 0.1 1.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_20 PF14561.1 CCF41155.1 - 0.019 15.0 0.4 0.03 14.4 0.3 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF4071 PF13281.1 CCF41155.1 - 0.031 13.1 0.0 0.039 12.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4071) DUF1218 PF06749.7 CCF41157.1 - 0.03 14.7 0.7 0.042 14.2 0.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1218) RskA PF10099.4 CCF41157.1 - 0.17 11.5 5.7 0.2 11.3 4.0 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA GTP_EFTU PF00009.22 CCF41158.1 - 1.6e-42 145.0 0.0 2.4e-42 144.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 CCF41158.1 - 2.5e-13 49.6 0.1 9.2e-13 47.8 0.0 2.1 3 0 0 3 3 3 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.20 CCF41158.1 - 1e-08 35.1 0.1 6.7e-08 32.5 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.1 CCF41158.1 - 2.8e-08 33.4 0.2 5.3e-07 29.4 0.0 2.4 2 0 0 2 2 2 1 Elongation Factor G, domain II MMR_HSR1 PF01926.18 CCF41158.1 - 5.9e-05 22.9 0.1 0.00013 21.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CCF41158.1 - 0.0013 19.2 0.0 0.0035 17.8 0.0 1.8 1 1 0 1 1 1 1 Miro-like protein Thiolase_N PF00108.18 CCF41159.1 - 1.6e-97 325.5 0.8 1.6e-97 325.5 0.6 1.5 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 CCF41159.1 - 3.4e-47 158.8 0.3 9.7e-47 157.4 0.2 1.8 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 CCF41159.1 - 4.3e-05 23.1 1.0 4.3e-05 23.1 0.7 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 CCF41159.1 - 0.13 11.9 3.5 2.2 8.0 0.0 2.8 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PAH PF02671.16 CCF41160.1 - 7.7e-44 147.0 2.5 7.3e-18 63.9 0.5 3.5 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.7 CCF41160.1 - 6.2e-38 128.6 0.0 1.5e-37 127.4 0.0 1.7 1 0 0 1 1 1 1 Sin3 family co-repressor Nuf2 PF03800.9 CCF41160.1 - 0.085 12.8 0.7 1 9.3 0.0 2.9 4 0 0 4 4 4 0 Nuf2 family Fasciclin PF02469.17 CCF41161.1 - 3.9e-05 23.6 0.0 5.8e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Fasciclin domain BORA_N PF15280.1 CCF41161.1 - 0.1 11.9 0.1 0.16 11.2 0.0 1.3 1 1 0 1 1 1 0 Protein aurora borealis N-terminus Linker_histone PF00538.14 CCF41162.1 - 1.4e-21 76.3 0.1 4.3e-21 74.7 0.1 1.9 1 0 0 1 1 1 1 linker histone H1 and H5 family Spot_14 PF07084.7 CCF41162.1 - 0.075 12.8 0.1 0.075 12.8 0.1 3.3 1 1 2 3 3 3 0 Thyroid hormone-inducible hepatic protein Spot 14 ADH_N PF08240.7 CCF41163.1 - 1.2e-21 76.4 3.3 2.1e-21 75.6 2.3 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF41163.1 - 2.1e-19 69.3 0.1 3.4e-19 68.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF41163.1 - 8.6e-06 26.6 0.0 1.6e-05 25.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 CCF41163.1 - 0.0088 15.2 0.3 0.014 14.5 0.2 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Fungal_trans_2 PF11951.3 CCF41164.1 - 1.3e-09 37.1 0.0 1.6e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41164.1 - 2.4e-08 33.7 10.7 3.8e-08 33.0 7.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Phosphoesterase PF04185.9 CCF41165.1 - 1.7e-21 76.8 0.1 2.2e-21 76.5 0.1 1.1 1 0 0 1 1 1 1 Phosphoesterase family TerY-C PF15616.1 CCF41166.1 - 0.081 12.8 0.9 0.11 12.3 0.5 1.3 1 1 0 1 1 1 0 TerY-C metal binding domain IPP-2 PF04979.9 CCF41167.1 - 1e-09 38.7 16.1 3.1e-08 33.9 10.1 2.5 1 1 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) SAGA-Tad1 PF12767.2 CCF41167.1 - 0.25 10.9 4.0 0.63 9.6 2.8 1.8 1 1 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Ssl1 PF04056.9 CCF41168.1 - 2.3e-73 245.8 0.0 3.1e-73 245.5 0.0 1.1 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.7 CCF41168.1 - 4.5e-16 58.5 7.0 4.5e-16 58.5 4.9 2.9 2 2 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.1 CCF41168.1 - 2e-10 41.0 0.0 3.1e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 CCF41168.1 - 0.024 14.3 0.0 0.037 13.7 0.0 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain Tfb4 PF03850.9 CCF41168.1 - 0.53 9.4 3.7 1.4 8.1 2.6 1.7 1 0 0 1 1 1 0 Transcription factor Tfb4 DZR PF12773.2 CCF41168.1 - 1.8 8.4 19.5 0.96 9.3 3.5 3.5 3 1 0 3 3 3 0 Double zinc ribbon COesterase PF00135.23 CCF41170.1 - 8.7e-90 301.9 0.0 1e-81 275.3 0.1 2.0 1 1 0 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF41170.1 - 5.4e-13 49.0 0.1 8.3e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF41170.1 - 0.0047 16.6 0.1 0.0085 15.8 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family MFS_1 PF07690.11 CCF41171.1 - 2.7e-27 95.4 21.0 4.3e-27 94.7 14.1 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily CopD PF05425.8 CCF41171.1 - 0.2 11.8 0.1 0.2 11.8 0.0 3.8 4 0 0 4 4 4 0 Copper resistance protein D DUF1049 PF06305.6 CCF41171.1 - 1.2 8.7 0.0 1.2 8.7 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1049) DUF4231 PF14015.1 CCF41171.1 - 1.7 8.6 6.5 0.33 10.9 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) Aldo_ket_red PF00248.16 CCF41172.1 - 7.3e-56 189.0 0.0 8.3e-56 188.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family WD40 PF00400.27 CCF41173.1 - 6.9e-20 70.1 4.0 1.7e-08 34.0 0.1 4.7 5 0 0 5 5 5 4 WD domain, G-beta repeat Ribosomal_L13 PF00572.13 CCF41174.1 - 2.3e-10 40.6 0.1 2.8e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L13 BAG PF02179.11 CCF41175.1 - 3.6e-19 68.6 0.9 6.7e-19 67.7 0.6 1.5 1 0 0 1 1 1 1 BAG domain ubiquitin PF00240.18 CCF41175.1 - 9.6e-05 21.7 0.0 0.00019 20.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Caps_synth_GfcC PF06251.6 CCF41175.1 - 0.056 12.6 0.4 1.6 7.8 0.1 2.1 2 0 0 2 2 2 0 Capsule biosynthesis GfcC RRM_1 PF00076.17 CCF41176.1 - 6.7e-22 76.9 0.0 1.3e-09 37.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF41176.1 - 7.5e-17 61.0 0.0 6.9e-08 32.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF41176.1 - 1.6e-11 43.8 0.0 4.5e-05 23.2 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PEX11 PF05648.9 CCF41177.1 - 8.3e-14 51.3 0.0 8.8e-14 51.3 0.0 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) PGAP1 PF07819.8 CCF41178.1 - 0.14 11.6 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein Bac_rhamnosid PF05592.6 CCF41179.1 - 2.2e-06 26.1 0.0 3.3e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase Sugar_tr PF00083.19 CCF41180.1 - 0.0024 16.5 2.9 0.0035 15.9 2.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter COPI_assoc PF08507.5 CCF41180.1 - 0.057 13.1 0.9 0.095 12.3 0.6 1.3 1 0 0 1 1 1 0 COPI associated protein Peptidase_M18 PF02127.10 CCF41181.1 - 2.5e-167 556.7 0.0 4.7e-167 555.8 0.0 1.4 1 1 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.9 CCF41181.1 - 1.6e-05 23.8 0.0 0.0045 15.7 0.0 2.9 3 0 0 3 3 3 2 M42 glutamyl aminopeptidase His_Phos_1 PF00300.17 CCF41182.1 - 4.6e-09 36.5 0.0 6.4e-07 29.5 0.0 2.6 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) zf-CCHC PF00098.18 CCF41183.1 - 3.4e-18 64.6 17.6 2.2e-09 36.7 3.0 3.1 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_3 PF13917.1 CCF41183.1 - 0.00045 19.8 10.3 0.051 13.3 1.7 2.1 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.1 CCF41183.1 - 0.00048 19.7 7.8 0.064 12.9 0.3 2.1 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.1 CCF41183.1 - 0.0037 16.7 11.0 0.0099 15.3 0.4 2.4 1 1 1 2 2 2 2 Zinc knuckle Prim_Zn_Ribbon PF08273.7 CCF41183.1 - 0.21 11.7 11.6 0.046 13.7 5.7 1.7 1 1 0 1 1 1 0 Zinc-binding domain of primase-helicase zf-CCHC_6 PF15288.1 CCF41183.1 - 0.23 11.1 7.8 0.56 9.9 3.4 2.3 1 1 1 2 2 2 0 Zinc knuckle eIF3g PF12353.3 CCF41183.1 - 0.35 10.7 9.3 0.1 12.4 0.9 2.0 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G IBR PF01485.16 CCF41183.1 - 1.1 9.1 11.9 26 4.7 8.2 2.1 1 1 0 1 1 1 0 IBR domain zf-CCHC_5 PF14787.1 CCF41183.1 - 4.5 6.8 7.9 1.8 8.1 0.3 2.2 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger ACI44 PF15270.1 CCF41183.1 - 5.5 7.0 6.8 4.9 7.2 1.7 2.3 1 1 1 2 2 2 0 Metallo-carboxypeptidase inhibitor AFP PF02420.10 CCF41183.1 - 7.8 7.0 13.3 0.99 9.7 1.8 3.4 4 0 0 4 4 3 0 Insect antifreeze protein repeat Acyl-CoA_dh_1 PF00441.19 CCF41184.1 - 2e-33 115.6 0.9 3e-33 115.0 0.6 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cyt-b5 PF00173.23 CCF41184.1 - 2.7e-20 71.9 0.1 7e-20 70.6 0.1 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_M PF02770.14 CCF41184.1 - 3.1e-15 55.4 0.6 6.2e-15 54.4 0.2 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.11 CCF41184.1 - 1.5e-11 44.8 0.1 1e-10 42.1 0.0 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 CCF41184.1 - 0.0012 19.0 0.0 0.0028 17.9 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain PI31_Prot_N PF11566.3 CCF41185.1 - 1e-30 106.3 0.0 1.2e-30 106.1 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.6 CCF41185.1 - 6.9e-17 61.8 21.6 6.9e-17 61.8 15.0 3.0 3 1 1 4 4 4 1 PI31 proteasome regulator HORMA PF02301.13 CCF41186.1 - 1.4e-19 70.3 0.0 1.9e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 HORMA domain ATG13 PF10033.4 CCF41186.1 - 0.089 12.1 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Autophagy-related protein 13 FA_desaturase PF00487.19 CCF41187.1 - 1.7e-14 53.8 16.2 3e-14 53.0 11.2 1.4 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.3 CCF41187.1 - 0.00019 21.4 0.0 0.00033 20.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Tannase PF07519.6 CCF41188.1 - 1.8e-24 86.3 0.0 1.9e-24 86.2 0.0 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Mito_carr PF00153.22 CCF41189.1 - 3.8e-19 68.1 5.1 1.7e-07 30.8 0.2 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein PBP1_TM PF14812.1 CCF41189.1 - 0.09 13.0 0.5 1.3 9.3 0.1 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Acyl-CoA_dh_2 PF08028.6 CCF41190.1 - 3.9e-07 30.3 0.0 4.7e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DUF2190 PF09956.4 CCF41190.1 - 0.031 14.0 0.0 0.032 13.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2190) UCH PF00443.24 CCF41191.1 - 8.1e-14 51.3 0.0 1.1e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.15 CCF41191.1 - 6.8e-05 23.1 0.0 0.00015 22.0 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain UCH_1 PF13423.1 CCF41191.1 - 0.15 11.5 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Methyltransf_11 PF08241.7 CCF41193.1 - 0.0011 19.4 0.0 0.0035 17.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF41193.1 - 0.55 9.2 0.0 0.93 8.5 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Ank_2 PF12796.2 CCF41194.1 - 1.5e-14 54.0 0.3 8e-08 32.5 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 CCF41194.1 - 3.8e-07 29.6 1.9 0.0061 16.3 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 CCF41194.1 - 2.7e-06 27.0 0.2 0.039 14.2 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 CCF41194.1 - 2e-05 24.6 1.4 0.021 15.0 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) F-box-like PF12937.2 CCF41194.1 - 0.0033 17.0 0.0 0.0067 16.1 0.0 1.6 1 0 0 1 1 1 1 F-box-like Ank_4 PF13637.1 CCF41194.1 - 0.0037 17.7 0.3 0.036 14.6 0.1 2.6 2 1 0 2 2 2 1 Ankyrin repeats (many copies) DUF2993 PF11209.3 CCF41195.1 - 0.012 15.5 0.0 0.019 14.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2993) Methyltransf_26 PF13659.1 CCF41195.1 - 0.18 11.8 0.8 1.9 8.5 0.5 2.3 1 1 0 1 1 1 0 Methyltransferase domain PKD_channel PF08016.7 CCF41197.1 - 1.7e-07 30.0 14.2 1.5e-05 23.6 9.8 2.3 1 1 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.26 CCF41197.1 - 0.0017 17.6 25.0 0.0019 17.5 7.7 2.6 3 0 0 3 3 3 2 Ion transport protein MFS_1 PF07690.11 CCF41198.1 - 1.3e-31 109.6 28.1 1.3e-31 109.6 19.4 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF619 PF04768.8 CCF41199.1 - 1.5e-47 161.1 0.0 2.2e-47 160.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF619) Semialdhyde_dh PF01118.19 CCF41199.1 - 2.7e-28 98.6 0.0 5.8e-28 97.6 0.0 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 CCF41199.1 - 0.01 15.7 0.0 0.023 14.6 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus GFO_IDH_MocA PF01408.17 CCF41199.1 - 0.052 14.0 0.0 0.19 12.2 0.0 2.0 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Fasciclin PF02469.17 CCF41200.1 - 8.3e-11 41.9 0.1 1.7e-10 40.9 0.0 1.5 2 0 0 2 2 2 1 Fasciclin domain PHBC_N PF12551.3 CCF41200.1 - 0.099 12.1 0.1 1.4 8.5 0.0 2.2 2 0 0 2 2 2 0 Poly-beta-hydroxybutyrate polymerase N terminal UNC-93 PF05978.11 CCF41202.1 - 9e-15 54.4 2.3 9e-15 54.4 1.6 2.8 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.11 CCF41202.1 - 4.2e-14 52.0 24.0 4.2e-14 52.0 16.6 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily OATP PF03137.15 CCF41202.1 - 0.11 10.5 7.1 1.1 7.1 0.7 2.7 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Glyco_hydro_16 PF00722.16 CCF41207.1 - 3.4e-12 46.0 0.8 7e-12 45.0 0.5 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 MFS_1 PF07690.11 CCF41208.1 - 1.2e-39 136.0 16.4 1.2e-39 136.0 11.3 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF41208.1 - 4.5e-06 25.1 4.0 6.9e-06 24.5 2.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Neurensin PF14927.1 CCF41208.1 - 0.6 9.4 2.8 0.74 9.2 0.3 2.4 2 0 0 2 2 2 0 Neurensin Adeno_E3_CR2 PF02439.10 CCF41209.1 - 0.019 14.5 0.9 0.047 13.2 0.6 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 MSC PF09402.5 CCF41209.1 - 0.15 10.7 0.0 0.18 10.4 0.0 1.1 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain Syndecan PF01034.15 CCF41209.1 - 0.21 11.2 1.9 0.37 10.4 1.3 1.3 1 0 0 1 1 1 0 Syndecan domain TMEM154 PF15102.1 CCF41209.1 - 2.5 7.8 12.6 5.3 6.7 8.7 1.6 1 1 0 1 1 1 0 TMEM154 protein family ABC_membrane PF00664.18 CCF41210.1 - 4e-41 141.2 18.8 2.6e-26 92.6 5.0 3.1 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.22 CCF41210.1 - 1e-18 67.9 0.0 9.9e-15 55.0 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_29 PF13555.1 CCF41210.1 - 7.9e-05 22.1 0.3 0.08 12.4 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 CCF41210.1 - 0.0012 18.0 0.9 0.0085 15.2 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 CCF41210.1 - 0.0016 18.4 0.4 0.021 14.8 0.1 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.1 CCF41210.1 - 0.014 15.2 0.1 0.22 11.3 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 CCF41210.1 - 0.041 14.6 2.1 0.07 13.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 CCF41210.1 - 0.15 12.1 0.8 0.61 10.2 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 CCF41210.1 - 0.15 11.7 0.2 0.41 10.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Rad17 PF03215.10 CCF41210.1 - 0.16 10.6 0.1 0.25 9.9 0.1 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_10 PF12846.2 CCF41210.1 - 0.17 11.3 0.1 14 4.9 0.1 2.4 2 0 0 2 2 2 0 AAA-like domain AAA_21 PF13304.1 CCF41210.1 - 0.53 10.2 0.0 0.53 10.2 0.0 1.7 2 0 0 2 2 1 0 AAA domain DUF87 PF01935.12 CCF41210.1 - 2.9 7.6 2.9 32 4.2 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF87 Polysacc_synt_4 PF04669.8 CCF41211.1 - 2.5e-26 92.2 1.5 1.5e-25 89.6 1.0 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis Elongin_A PF06881.6 CCF41211.1 - 0.007 16.7 0.2 0.01 16.2 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A DUF2491 PF10679.4 CCF41211.1 - 0.025 13.5 0.5 0.031 13.3 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2491) DUF1912 PF08930.5 CCF41211.1 - 0.064 13.3 1.0 0.12 12.4 0.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1912) DUF573 PF04504.9 CCF41212.1 - 0.33 11.2 4.3 0.6 10.4 3.0 1.6 1 1 0 1 1 1 0 Protein of unknown function, DUF573 FemAB PF02388.11 CCF41212.1 - 9 4.8 14.1 10 4.6 9.8 1.2 1 0 0 1 1 1 0 FemAB family Aa_trans PF01490.13 CCF41213.1 - 4.6e-71 239.4 32.8 5.7e-71 239.1 22.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PseudoU_synth_1 PF01416.15 CCF41214.1 - 0.039 14.3 0.1 0.043 14.2 0.0 1.1 1 0 0 1 1 1 0 tRNA pseudouridine synthase DUF2841 PF11001.3 CCF41216.1 - 4.6e-41 139.6 7.0 6.8e-41 139.0 4.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) Methyltransf_2 PF00891.13 CCF41218.1 - 6.8e-32 110.5 0.0 9e-32 110.1 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase WSK PF03832.8 CCF41220.1 - 4.7 6.6 5.9 8.2 5.8 4.1 1.3 1 0 0 1 1 1 0 WSK motif CVNH PF08881.5 CCF41221.1 - 1.2e-08 35.0 0.1 2.7e-08 33.9 0.1 1.6 1 1 0 1 1 1 1 CVNH domain DUF1158 PF06643.6 CCF41222.1 - 0.14 12.4 0.0 0.21 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1158) MFS_1 PF07690.11 CCF41224.1 - 1.1e-38 132.8 9.8 1.8e-38 132.1 6.8 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF41224.1 - 3.1e-10 39.0 0.0 0.00038 18.9 2.2 3.4 2 1 1 3 3 3 2 MFS/sugar transport protein Sugar_tr PF00083.19 CCF41224.1 - 2e-08 33.2 8.4 2e-08 33.2 5.8 3.1 2 2 0 3 3 3 1 Sugar (and other) transporter MFS_3 PF05977.8 CCF41224.1 - 0.00078 17.6 3.1 0.00078 17.6 2.2 2.3 2 0 0 2 2 2 1 Transmembrane secretion effector AT_hook PF02178.14 CCF41225.1 - 4 7.4 5.7 27 4.8 0.3 2.7 2 0 0 2 2 2 0 AT hook motif MFS_1 PF07690.11 CCF41227.1 - 1.3e-29 103.0 32.2 1.7e-29 102.6 22.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF773 PF05600.7 CCF41229.1 - 0.006 15.4 0.2 0.012 14.4 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF773) DUF3450 PF11932.3 CCF41229.1 - 0.023 13.9 0.1 0.043 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Baculo_PEP_C PF04513.7 CCF41229.1 - 0.15 11.9 4.3 0.72 9.6 0.9 2.8 2 2 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Dicty_REP PF05086.7 CCF41231.1 - 1.2 6.7 6.1 1.7 6.3 4.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Glyco_hydro_72 PF03198.9 CCF41232.1 - 2e-115 385.1 0.1 2.4e-115 384.8 0.1 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.13 CCF41232.1 - 0.0045 16.2 0.0 0.054 12.6 0.0 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) BC10 PF06726.7 CCF41233.1 - 0.002 18.0 0.2 0.0045 16.9 0.1 1.6 1 1 1 2 2 2 1 Bladder cancer-related protein BC10 Cyclase PF04199.8 CCF41234.1 - 1.2e-13 51.1 0.6 1.6e-13 50.7 0.4 1.2 1 0 0 1 1 1 1 Putative cyclase Amidohydro_4 PF13147.1 CCF41234.1 - 0.015 15.3 0.7 0.024 14.7 0.5 1.3 1 0 0 1 1 1 0 Amidohydrolase B3_4 PF03483.12 CCF41235.1 - 2.4e-27 95.5 0.0 3.9e-27 94.8 0.0 1.3 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.10 CCF41235.1 - 5.5e-17 61.3 0.0 1.1e-13 50.7 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetase B5 domain tRNA-synt_2d PF01409.15 CCF41235.1 - 0.041 13.0 0.0 7.4 5.6 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) Ecl1 PF12855.2 CCF41236.1 - 0.0054 16.0 0.2 0.013 14.7 0.2 1.6 1 0 0 1 1 1 1 Life-span regulatory factor DUF2256 PF10013.4 CCF41236.1 - 0.034 13.8 1.9 0.56 10.0 0.4 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) DBR1 PF05011.8 CCF41238.1 - 0.062 13.1 0.1 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Lariat debranching enzyme, C-terminal domain DUF3115 PF11312.3 CCF41241.1 - 3.5e-66 223.2 0.0 4.3e-66 222.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3115) Syja_N PF02383.13 CCF41242.1 - 1.4e-62 211.3 0.1 2.1e-62 210.7 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.3 CCF41242.1 - 1.3e-34 118.0 0.0 2.5e-34 117.1 0.0 1.5 1 0 0 1 1 1 1 Inositol phosphatase MFS_1 PF07690.11 CCF41245.1 - 2.4e-25 89.0 53.8 2.1e-16 59.6 15.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CCF41245.1 - 0.0021 16.5 35.1 0.023 13.0 3.5 2.7 1 1 1 2 2 2 2 MFS/sugar transport protein Pec_lyase_C PF00544.14 CCF41246.1 - 3e-47 160.7 2.3 4e-47 160.2 1.6 1.2 1 0 0 1 1 1 1 Pectate lyase Abhydrolase_1 PF00561.15 CCF41247.1 - 2e-12 47.1 0.2 8.8e-12 45.0 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF41247.1 - 1.4e-10 41.4 0.0 2.2e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family HTH_psq PF05225.11 CCF41248.1 - 1.7e-13 49.8 0.0 4.1e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF41248.1 - 1.4e-09 37.5 0.1 3.3e-09 36.4 0.0 1.7 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 CCF41248.1 - 0.00047 19.3 0.0 0.00087 18.4 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.1 CCF41248.1 - 0.0061 16.1 0.0 0.039 13.6 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 CCF41248.1 - 0.015 15.2 0.1 0.098 12.6 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain HSCB_C PF07743.8 CCF41251.1 - 9.8e-16 57.9 7.0 1.4e-15 57.4 3.2 2.0 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.26 CCF41251.1 - 4.1e-11 42.4 0.1 8.8e-11 41.3 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain FMN_dh PF01070.13 CCF41252.1 - 3.1e-109 365.0 0.0 4.1e-109 364.6 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 CCF41252.1 - 5.6e-22 77.3 0.0 1.5e-21 75.9 0.0 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.12 CCF41252.1 - 2.5e-07 29.9 0.1 4.1e-07 29.2 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.20 CCF41252.1 - 7.2e-06 25.1 0.2 0.00013 20.9 0.1 2.2 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.16 CCF41252.1 - 0.011 15.0 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein NMO PF03060.10 CCF41252.1 - 0.02 14.0 0.2 0.033 13.3 0.1 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase Ribul_P_3_epim PF00834.14 CCF41252.1 - 0.1 11.6 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family DHO_dh PF01180.16 CCF41252.1 - 0.11 11.4 0.0 0.2 10.5 0.0 1.4 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase EHN PF06441.7 CCF41253.1 - 3.3e-34 117.1 0.3 4.8e-34 116.6 0.2 1.2 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_6 PF12697.2 CCF41253.1 - 6.4e-10 39.2 0.2 1.8e-09 37.8 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF41253.1 - 0.0018 17.8 0.0 0.0025 17.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Metallophos PF00149.23 CCF41254.1 - 3.7e-07 29.7 0.2 5.1e-07 29.2 0.1 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CCF41254.1 - 0.00042 20.1 0.0 0.00044 20.1 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Cyclin PF08613.6 CCF41255.1 - 4.1e-14 53.2 0.0 1e-13 51.9 0.0 1.7 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 CCF41255.1 - 0.015 14.8 0.0 0.036 13.6 0.0 1.6 1 0 0 1 1 1 0 Cyclin, N-terminal domain DUF1295 PF06966.7 CCF41256.1 - 4.6e-58 196.2 0.3 6e-58 195.9 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.11 CCF41256.1 - 6.2e-07 29.2 0.1 6.2e-07 29.2 0.1 2.8 1 1 1 3 3 3 1 3-oxo-5-alpha-steroid 4-dehydrogenase ICMT PF04140.9 CCF41256.1 - 3.4e-05 23.9 0.8 0.00052 20.1 0.0 2.7 2 1 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 CCF41256.1 - 0.00051 20.1 0.0 0.00051 20.1 0.0 2.7 3 1 0 4 4 4 1 Phospholipid methyltransferase ERG4_ERG24 PF01222.12 CCF41256.1 - 0.019 13.5 0.3 0.019 13.5 0.2 2.3 2 1 0 2 2 2 0 Ergosterol biosynthesis ERG4/ERG24 family GFA PF04828.9 CCF41257.1 - 9.5e-19 67.1 1.0 1.4e-18 66.5 0.7 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Nudix_N_2 PF14803.1 CCF41257.1 - 0.075 12.7 0.1 0.075 12.7 0.0 2.6 2 1 0 2 2 2 0 Nudix N-terminal Cys_rich_CWC PF14375.1 CCF41257.1 - 4.6 7.2 8.7 0.3 11.0 2.1 1.9 2 0 0 2 2 2 0 Cysteine-rich CWC DUF35_N PF12172.3 CCF41257.1 - 8.2 6.4 7.5 3.9 7.5 0.1 2.9 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Sugar_tr PF00083.19 CCF41258.1 - 3.2e-62 210.5 14.3 3.6e-62 210.4 9.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF41258.1 - 0.0002 20.1 27.6 0.0002 20.1 19.2 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily SpoIIIAC PF06686.6 CCF41258.1 - 0.025 14.3 1.0 0.2 11.5 0.0 2.4 2 0 0 2 2 2 0 Stage III sporulation protein AC/AD protein family PEPCK_ATP PF01293.15 CCF41259.1 - 3.3e-191 635.8 0.0 3.8e-191 635.6 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_29 PF13555.1 CCF41259.1 - 0.024 14.1 0.0 0.061 12.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.1 CCF41259.1 - 0.072 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CCF41259.1 - 0.084 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain p450 PF00067.17 CCF41261.1 - 2.6e-51 174.5 0.0 3.5e-51 174.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cupin_8 PF13621.1 CCF41262.1 - 2.2e-26 92.8 0.0 2.4e-26 92.7 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 CCF41262.1 - 0.0032 16.7 0.0 0.0079 15.4 0.0 1.7 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.17 CCF41262.1 - 0.0057 16.8 0.0 0.062 13.5 0.0 2.5 2 1 0 2 2 2 1 JmjC domain, hydroxylase Cupin_2 PF07883.6 CCF41262.1 - 0.017 14.6 0.0 0.034 13.6 0.0 1.5 1 0 0 1 1 1 0 Cupin domain CK_II_beta PF01214.13 CCF41263.1 - 2.5e-76 255.3 0.0 5.2e-76 254.2 0.0 1.5 1 1 0 1 1 1 1 Casein kinase II regulatory subunit Spt5_N PF11942.3 CCF41263.1 - 0.0012 19.4 8.0 0.0012 19.4 5.6 2.4 2 0 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal RRN3 PF05327.6 CCF41263.1 - 0.13 10.4 2.4 0.19 9.8 1.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 LZ_Tnp_IS66 PF13007.2 CCF41263.1 - 1.2 9.8 7.8 0.39 11.3 0.4 2.4 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain Glyco_hydro_43 PF04616.9 CCF41264.1 - 4.1e-41 140.9 6.4 4.7e-41 140.7 4.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 PD40 PF07676.7 CCF41264.1 - 0.0078 15.8 0.9 0.048 13.3 0.2 2.4 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat DUF2434 PF10361.4 CCF41265.1 - 1.3e-18 67.1 1.0 1.5e-18 66.8 0.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2434) Kelch_1 PF01344.20 CCF41265.1 - 0.076 12.5 0.4 0.14 11.7 0.3 1.7 1 1 0 1 1 1 0 Kelch motif COG5 PF10392.4 CCF41266.1 - 3.5e-40 137.0 0.9 3.5e-40 137.0 0.6 2.4 3 0 0 3 3 3 1 Golgi transport complex subunit 5 SPX PF03105.14 CCF41266.1 - 0.1 12.3 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 SPX domain Sec5 PF15469.1 CCF41266.1 - 0.11 12.2 0.1 1.2 8.8 0.1 2.2 2 0 0 2 2 2 0 Exocyst complex component Sec5 MutS_III PF05192.13 CCF41266.1 - 0.44 10.2 4.3 10 5.8 0.0 2.6 2 1 0 2 2 2 0 MutS domain III Pyr_redox_2 PF07992.9 CCF41267.1 - 1.3e-06 28.4 0.0 1.4e-06 28.3 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Remorin_N PF03766.8 CCF41268.1 - 0.24 11.2 2.5 5.7 6.8 0.2 2.4 2 0 0 2 2 2 0 Remorin, N-terminal region MHYT PF03707.11 CCF41269.1 - 3.8e-06 26.9 22.2 0.00011 22.2 0.9 4.1 3 2 0 3 3 3 2 Bacterial signalling protein N terminal repeat MFS_1 PF07690.11 CCF41270.1 - 1.4e-37 129.2 41.1 1.3e-36 126.0 18.8 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily K_oxygenase PF13434.1 CCF41271.1 - 2e-80 270.2 0.0 2.5e-80 269.9 0.0 1.0 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.1 CCF41271.1 - 2.2e-09 37.6 0.0 3.1e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF41271.1 - 3.8e-07 30.0 0.0 2.3e-06 27.4 0.0 2.0 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 CCF41271.1 - 0.00029 20.7 0.0 0.00077 19.3 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DUF4147 PF13660.1 CCF41271.1 - 0.025 13.7 0.0 1.4 7.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4147) Mqo PF06039.10 CCF41271.1 - 0.13 10.3 0.0 0.21 9.7 0.0 1.3 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) FMO-like PF00743.14 CCF41271.1 - 0.19 9.8 0.0 0.26 9.4 0.0 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like ABC2_membrane PF01061.19 CCF41272.1 - 5.3e-48 162.9 32.5 9.6e-42 142.5 18.0 2.7 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.7 CCF41272.1 - 4.4e-35 119.4 0.0 4.4e-35 119.4 0.0 2.1 3 0 0 3 3 1 1 CDR ABC transporter ABC_tran PF00005.22 CCF41272.1 - 4e-23 82.2 0.0 2.6e-16 60.1 0.0 3.4 3 0 0 3 3 3 2 ABC transporter ABC2_membrane_3 PF12698.2 CCF41272.1 - 4e-05 22.8 24.6 0.00016 20.8 17.0 1.8 1 1 0 1 1 1 1 ABC-2 family transporter protein DUF258 PF03193.11 CCF41272.1 - 5.1e-05 22.5 0.0 9e-05 21.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_25 PF13481.1 CCF41272.1 - 8e-05 22.1 0.0 0.00016 21.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF41272.1 - 0.00035 20.6 0.1 0.0012 18.9 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 CCF41272.1 - 0.0015 18.4 0.1 0.006 16.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain cobW PF02492.14 CCF41272.1 - 0.0018 17.7 0.1 0.0032 16.9 0.0 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain SMC_N PF02463.14 CCF41272.1 - 0.0052 16.0 0.0 0.46 9.6 0.0 2.5 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 CCF41272.1 - 0.0067 15.9 0.1 0.016 14.7 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.1 CCF41272.1 - 0.0076 16.5 0.0 0.029 14.6 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_17 PF13207.1 CCF41272.1 - 0.021 15.6 0.0 0.096 13.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.1 CCF41272.1 - 0.026 14.4 0.1 0.81 9.5 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.1 CCF41272.1 - 0.15 12.2 0.0 0.52 10.4 0.0 2.0 2 0 0 2 2 1 0 AAA domain Thymidylate_kin PF02223.12 CCF41272.1 - 0.15 11.4 0.2 2.5 7.4 0.0 2.5 2 0 0 2 2 2 0 Thymidylate kinase DUF3357 PF11837.3 CCF41273.1 - 0.012 15.4 1.5 0.018 14.8 0.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) DUF401 PF04165.7 CCF41273.1 - 0.13 11.2 0.1 0.16 10.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF401) CytB6-F_Fe-S PF08802.5 CCF41273.1 - 0.19 11.7 0.4 0.52 10.3 0.3 1.8 1 0 0 1 1 1 0 Cytochrome B6-F complex Fe-S subunit LRR_4 PF12799.2 CCF41275.1 - 1.8e-05 24.2 0.2 0.14 11.7 0.0 3.0 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) F-box-like PF12937.2 CCF41275.1 - 0.0013 18.4 0.4 0.0042 16.7 0.1 2.1 2 0 0 2 2 2 1 F-box-like LRR_8 PF13855.1 CCF41275.1 - 0.0015 18.2 6.2 0.027 14.2 0.8 3.5 4 0 0 4 4 4 2 Leucine rich repeat BAR PF03114.13 CCF41276.1 - 7.6e-64 215.3 5.1 1.1e-63 214.8 3.5 1.2 1 0 0 1 1 1 1 BAR domain CP12 PF02672.10 CCF41276.1 - 0.054 13.9 0.1 0.3 11.5 0.0 2.3 2 0 0 2 2 2 0 CP12 domain FliD_N PF02465.13 CCF41276.1 - 1.4 9.3 5.4 0.91 9.9 0.2 2.5 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Pept_tRNA_hydro PF01195.14 CCF41277.1 - 9e-28 97.0 0.0 1.1e-27 96.7 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase Acetyltransf_1 PF00583.19 CCF41278.1 - 1.3e-12 47.5 0.0 2.4e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF41278.1 - 0.064 13.4 0.0 0.24 11.5 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain UCH PF00443.24 CCF41279.1 - 4.2e-49 167.0 0.0 7.8e-49 166.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CCF41279.1 - 4.1e-14 52.7 0.0 1.4e-13 50.9 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase HNOBA PF07701.9 CCF41279.1 - 0.058 12.5 0.0 0.098 11.8 0.0 1.3 1 0 0 1 1 1 0 Heme NO binding associated SAE2 PF08573.5 CCF41280.1 - 5.3e-26 91.1 0.0 5.3e-26 91.1 0.0 3.1 3 1 1 4 4 4 1 DNA repair protein endonuclease SAE2/CtIP C-terminus BEX PF04538.7 CCF41280.1 - 0.023 14.8 0.6 0.023 14.8 0.4 3.7 4 1 0 4 4 4 0 Brain expressed X-linked like family Fib_alpha PF08702.5 CCF41280.1 - 2 8.5 7.3 0.65 10.1 2.2 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family zf-CCHC PF00098.18 CCF41283.1 - 4.5e-07 29.4 7.3 0.00023 20.9 0.5 2.2 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.1 CCF41283.1 - 0.069 12.8 2.5 0.31 10.7 0.1 2.1 2 0 0 2 2 2 0 Zinc knuckle zf-ribbon_3 PF13248.1 CCF41283.1 - 0.15 11.2 7.3 1.5 8.1 0.5 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-CCHC_6 PF15288.1 CCF41283.1 - 0.37 10.4 7.5 0.78 9.4 1.0 2.3 1 1 1 2 2 2 0 Zinc knuckle Amidase PF01425.16 CCF41284.1 - 3.5e-67 227.1 0.2 2.3e-65 221.2 0.0 2.1 2 0 0 2 2 2 2 Amidase DUF1490 PF07371.7 CCF41285.1 - 0.54 10.2 2.8 0.91 9.5 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1490) AF-4 PF05110.8 CCF41286.1 - 1.5 6.6 19.6 1.5 6.6 13.6 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CDK2AP PF09806.4 CCF41286.1 - 2.5 8.2 8.1 3.1 7.9 5.6 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Corona_nucleoca PF00937.13 CCF41286.1 - 5.8 5.7 16.9 6.3 5.6 11.7 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Period_C PF12114.3 CCF41286.1 - 8.5 5.9 12.5 9.4 5.7 8.6 1.2 1 0 0 1 1 1 0 Period protein 2/3C-terminal region BOP1NT PF08145.7 CCF41287.1 - 1.5e-50 172.3 0.0 3.3e-50 171.2 0.0 1.5 2 0 0 2 2 2 1 BOP1NT (NUC169) domain FAD_binding_3 PF01494.14 CCF41288.1 - 4.2e-27 95.1 0.0 6.4e-27 94.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF41288.1 - 2.3e-06 26.7 0.4 0.0093 14.9 0.2 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 CCF41288.1 - 1.1e-05 25.6 0.9 0.00018 21.8 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF41288.1 - 0.00018 21.4 0.0 0.00055 19.9 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 CCF41288.1 - 0.0028 16.6 0.1 0.3 9.9 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Amino_oxidase PF01593.19 CCF41288.1 - 0.0043 16.1 0.2 1.6 7.6 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.9 CCF41288.1 - 0.16 11.8 0.2 1.1 9.0 0.1 2.1 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF41288.1 - 0.32 9.5 3.2 1.1 7.7 0.1 2.1 1 1 1 2 2 2 0 Tryptophan halogenase CUE PF02845.11 CCF41290.1 - 5.9e-07 28.8 0.1 1e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 CUE domain RE_AlwI PF09491.5 CCF41293.1 - 0.097 11.1 0.2 0.12 10.7 0.2 1.0 1 0 0 1 1 1 0 AlwI restriction endonuclease FMO-like PF00743.14 CCF41294.1 - 5.9e-26 90.7 0.0 3.4e-14 51.9 0.0 3.1 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 CCF41294.1 - 1.6e-17 64.2 0.1 3.2e-12 46.9 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF41294.1 - 3.9e-11 42.4 0.2 2.7e-08 33.1 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 CCF41294.1 - 1.3e-10 41.4 0.0 7.8e-08 32.4 0.0 3.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF41294.1 - 2.5e-09 37.1 0.9 8.3e-05 22.4 0.0 3.5 3 0 0 3 3 3 2 FAD-NAD(P)-binding DAO PF01266.19 CCF41294.1 - 0.00031 19.7 2.7 0.78 8.5 0.2 3.2 2 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF41294.1 - 0.00032 20.6 0.0 0.001 19.0 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 CCF41294.1 - 0.0039 16.3 0.2 0.03 13.4 0.0 2.0 2 0 0 2 2 2 1 Thi4 family Semialdhyde_dh PF01118.19 CCF41294.1 - 0.076 13.3 0.0 0.48 10.7 0.0 2.4 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Fungal_trans PF04082.13 CCF41296.1 - 1.2e-11 43.9 0.1 2.5e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41296.1 - 4.6e-05 23.2 7.3 9.5e-05 22.2 5.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Polysacc_deac_1 PF01522.16 CCF41297.1 - 5.3e-23 80.9 0.0 1.1e-22 79.9 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.4 CCF41297.1 - 0.084 12.2 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) ADH_N PF08240.7 CCF41298.1 - 3.9e-21 74.8 0.1 7.7e-21 73.9 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF41298.1 - 1.4e-16 60.2 0.2 3.4e-16 58.9 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 CCF41298.1 - 0.07 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Amidase PF01425.16 CCF41299.1 - 6.5e-94 315.2 0.2 8.3e-94 314.9 0.1 1.1 1 0 0 1 1 1 1 Amidase MSP1b PF03429.8 CCF41299.1 - 0.26 9.1 0.0 0.39 8.5 0.0 1.2 1 0 0 1 1 1 0 Major surface protein 1B adh_short_C2 PF13561.1 CCF41300.1 - 5.2e-27 95.1 0.0 6e-27 94.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF41300.1 - 1.4e-23 83.6 0.4 2.8e-23 82.6 0.1 1.5 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 CCF41300.1 - 1.2e-09 38.0 0.8 2e-09 37.3 0.1 1.7 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.10 CCF41300.1 - 0.016 14.1 0.0 0.024 13.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ThiF PF00899.16 CCF41300.1 - 0.028 14.2 1.1 0.13 12.0 0.6 2.2 2 1 0 2 2 2 0 ThiF family F420_oxidored PF03807.12 CCF41300.1 - 0.12 12.8 0.4 0.33 11.3 0.2 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Fungal_trans PF04082.13 CCF41302.1 - 1.6e-13 50.1 0.1 3.3e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain GATA PF00320.22 CCF41303.1 - 8e-15 53.8 3.4 1.3e-14 53.2 2.4 1.3 1 0 0 1 1 1 1 GATA zinc finger Aldo_ket_red PF00248.16 CCF41305.1 - 1.9e-30 105.6 0.0 2.2e-30 105.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family IDO PF01231.13 CCF41306.1 - 2.2e-47 161.4 0.0 2.7e-47 161.1 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase SNF5 PF04855.7 CCF41309.1 - 1.9e-11 43.9 0.0 3.8e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 Zn_clus PF00172.13 CCF41311.1 - 0.039 13.8 4.1 0.073 12.9 2.8 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2834 PF11196.3 CCF41312.1 - 6.2e-06 26.2 0.8 6.2e-06 26.2 0.5 3.0 3 1 0 3 3 3 1 Protein of unknown function (DUF2834) Glyco_hydro_76 PF03663.9 CCF41314.1 - 1e-148 495.6 14.3 1.3e-148 495.3 9.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Sugar_tr PF00083.19 CCF41315.1 - 9.2e-128 426.6 25.6 1.1e-127 426.3 17.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF41315.1 - 2.7e-29 101.9 60.7 2.5e-22 79.0 20.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.11 CCF41315.1 - 0.012 14.3 0.9 0.012 14.3 0.6 2.6 2 1 0 2 2 2 0 BT1 family Sugar_tr PF00083.19 CCF41317.1 - 1.2e-05 24.0 1.9 1.4e-05 23.8 1.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF41317.1 - 0.0095 14.6 0.0 0.011 14.5 0.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Carb_anhydrase PF00194.16 CCF41318.1 - 3.5e-24 85.1 0.0 5.1e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase MFS_1 PF07690.11 CCF41319.1 - 3.8e-19 68.6 58.6 1.3e-13 50.3 25.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MDM31_MDM32 PF08118.6 CCF41321.1 - 6.4e-185 615.3 1.6 3.6e-184 612.9 1.1 1.8 1 1 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins Sgf11 PF08209.6 CCF41323.1 - 0.22 10.8 7.7 0.029 13.6 2.3 1.7 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) zf-C2HC_2 PF13913.1 CCF41323.1 - 7.7 6.3 7.6 0.32 10.7 0.8 1.9 2 0 0 2 2 2 0 zinc-finger of a C2HC-type SnoaL_2 PF12680.2 CCF41324.1 - 0.12 12.8 0.1 0.19 12.1 0.0 1.5 1 1 0 1 1 1 0 SnoaL-like domain MFS_1 PF07690.11 CCF41325.1 - 1.6e-32 112.6 34.6 1.8e-31 109.1 21.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1614 PF07758.6 CCF41325.1 - 0.05 13.3 4.7 0.039 13.6 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1614) PDGLE PF13190.1 CCF41325.1 - 0.69 9.6 3.6 11 5.7 0.2 3.8 3 1 0 3 3 3 0 PDGLE domain FBPase PF00316.15 CCF41326.1 - 2.7e-22 79.0 0.1 4.4e-22 78.3 0.1 1.3 1 1 0 1 1 1 1 Fructose-1-6-bisphosphatase PAP2 PF01569.16 CCF41327.1 - 9e-20 70.6 2.8 9e-20 70.6 1.9 1.6 2 0 0 2 2 2 1 PAP2 superfamily DUF983 PF06170.7 CCF41327.1 - 0.63 10.1 4.2 4.4 7.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF983) Sporozoite_P67 PF05642.6 CCF41328.1 - 8.1 4.1 9.9 8.8 4.0 6.9 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen p450 PF00067.17 CCF41329.1 - 2e-36 125.5 0.0 1.1e-27 96.7 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 2-Hacid_dh_C PF02826.14 CCF41330.1 - 1.7e-31 108.7 0.0 1.8e-30 105.3 0.0 2.1 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain adh_short PF00106.20 CCF41331.1 - 2.5e-23 82.8 0.3 3.5e-23 82.3 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF41331.1 - 4.7e-11 42.6 0.1 8.9e-11 41.7 0.1 1.5 1 1 0 1 1 1 1 KR domain 3Beta_HSD PF01073.14 CCF41331.1 - 0.025 13.3 0.0 0.041 12.5 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Ras PF00071.17 CCF41332.1 - 3.8e-43 146.6 0.0 5.7e-43 146.1 0.0 1.3 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF41332.1 - 2.4e-15 57.0 0.0 3.8e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CCF41332.1 - 9.3e-11 41.2 0.0 2.8e-10 39.6 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 CCF41332.1 - 0.0013 18.6 0.0 0.0023 17.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.1 CCF41332.1 - 0.0018 18.1 0.0 0.0032 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Gtr1_RagA PF04670.7 CCF41332.1 - 0.0021 17.2 0.0 0.0028 16.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.4 CCF41332.1 - 0.0086 15.5 0.0 0.45 9.9 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.1 CCF41332.1 - 0.0088 16.0 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CCF41332.1 - 0.011 15.9 0.0 0.019 15.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 CCF41332.1 - 0.017 14.3 0.0 0.03 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 SRPRB PF09439.5 CCF41332.1 - 0.036 13.2 0.0 0.05 12.8 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.1 CCF41332.1 - 0.042 13.8 0.0 0.093 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.22 CCF41332.1 - 0.056 13.7 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Arch_ATPase PF01637.13 CCF41332.1 - 0.1 12.2 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase NACHT PF05729.7 CCF41332.1 - 0.15 11.7 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Glyco_hydro_2 PF00703.16 CCF41333.1 - 1.3e-13 51.4 0.1 3.1e-13 50.1 0.1 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.13 CCF41333.1 - 8.7e-11 41.6 0.1 2.6e-10 40.1 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.12 CCF41333.1 - 7.9e-06 24.9 0.0 1.3e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Alg6_Alg8 PF03155.10 CCF41334.1 - 6.1e-142 473.7 27.2 7.6e-142 473.4 18.9 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Ank PF00023.25 CCF41335.1 - 8.9e-68 220.9 16.2 1.5e-11 43.4 0.1 12.9 14 0 0 14 14 14 8 Ankyrin repeat Ank_2 PF12796.2 CCF41335.1 - 9e-68 224.6 10.1 1.5e-18 66.8 0.1 6.7 2 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF41335.1 - 2.4e-51 171.2 16.9 3.9e-12 46.3 0.0 9.4 2 1 8 10 10 10 7 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF41335.1 - 4.8e-45 147.0 1.2 1.8e-06 27.6 0.0 11.4 12 0 0 12 12 12 7 Ankyrin repeat Ank_5 PF13857.1 CCF41335.1 - 8.8e-38 127.4 13.7 3.3e-09 36.6 0.1 8.0 3 1 6 9 9 8 6 Ankyrin repeats (many copies) HTH_Tnp_Tc5 PF03221.11 CCF41335.1 - 0.017 14.9 0.7 9.6 6.1 0.0 4.4 3 1 2 5 5 5 0 Tc5 transposase DNA-binding domain Ferritin PF00210.19 CCF41335.1 - 0.027 14.2 6.2 8.4 6.1 0.4 3.2 1 1 1 3 3 3 0 Ferritin-like domain TniB PF05621.6 CCF41335.1 - 0.031 13.0 0.1 0.085 11.6 0.1 1.7 1 1 0 1 1 1 0 Bacterial TniB protein DUF1843 PF08898.5 CCF41335.1 - 0.04 13.9 1.2 14 5.8 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF1843) C1_2 PF03107.11 CCF41335.1 - 0.33 11.1 10.2 0.59 10.3 7.1 1.4 1 0 0 1 1 1 0 C1 domain zf-UBR PF02207.15 CCF41335.1 - 3.9 7.2 10.4 0.47 10.2 4.1 1.7 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) Mit_KHE1 PF10173.4 CCF41336.1 - 1.2e-62 211.1 1.2 1.2e-62 211.1 0.0 1.5 2 0 0 2 2 2 1 Mitochondrial K+-H+ exchange-related Glyco_tranf_2_4 PF13704.1 CCF41337.1 - 0.072 13.4 0.5 0.11 12.8 0.4 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 2 DDE_1 PF03184.14 CCF41338.1 - 6e-56 188.9 0.0 9.3e-56 188.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 CCF41338.1 - 1.3e-11 44.1 0.1 3.5e-11 42.7 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF41338.1 - 1.9e-11 43.3 0.2 3.8e-11 42.3 0.2 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.1 CCF41338.1 - 2e-08 34.0 0.0 6.1e-08 32.5 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_28 PF13518.1 CCF41338.1 - 0.0017 18.2 1.2 0.0031 17.4 0.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 CCF41338.1 - 0.0032 17.0 0.1 0.011 15.3 0.1 2.0 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.10 CCF41338.1 - 0.013 15.3 0.6 0.031 14.1 0.4 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_Tnp_IS630 PF01710.11 CCF41338.1 - 0.033 13.8 0.0 0.075 12.6 0.0 1.6 1 0 0 1 1 1 0 Transposase HTH_8 PF02954.14 CCF41338.1 - 0.045 13.2 0.1 0.12 11.9 0.1 1.7 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family Zn_clus PF00172.13 CCF41339.1 - 0.00034 20.4 12.8 0.00034 20.4 8.8 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.21 CCF41339.1 - 0.0038 17.4 1.3 0.0038 17.4 0.9 2.1 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-met PF12874.2 CCF41339.1 - 0.0085 16.2 0.2 0.019 15.1 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 CCF41339.1 - 0.019 15.2 1.4 0.019 15.2 1.0 2.2 2 1 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CCF41339.1 - 0.027 14.6 0.1 0.053 13.6 0.1 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Cation_efflux PF01545.16 CCF41341.1 - 6.6e-57 192.7 0.6 8.6e-57 192.3 0.4 1.1 1 0 0 1 1 1 1 Cation efflux family DUF4066 PF13278.1 CCF41342.1 - 4.2e-20 71.6 0.0 5.3e-20 71.3 0.0 1.1 1 0 0 1 1 1 1 Putative amidotransferase DJ-1_PfpI PF01965.19 CCF41342.1 - 2.9e-10 39.7 0.0 4.1e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family ABC_tran PF00005.22 CCF41343.1 - 1.7e-51 174.0 0.0 1.5e-30 106.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 CCF41343.1 - 1.7e-36 126.0 23.5 2.1e-22 79.8 6.6 3.1 2 1 1 3 3 3 2 ABC transporter transmembrane region AAA_21 PF13304.1 CCF41343.1 - 4.1e-10 40.0 0.0 9.4e-05 22.5 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.1 CCF41343.1 - 1.2e-09 37.5 0.2 0.0011 18.4 0.0 3.1 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_17 PF13207.1 CCF41343.1 - 7.4e-09 36.4 0.0 0.0014 19.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 CCF41343.1 - 5.6e-08 32.9 0.7 0.0014 18.6 0.3 2.7 2 0 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.14 CCF41343.1 - 6.1e-08 32.1 1.2 0.00089 18.5 0.0 3.3 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_10 PF12846.2 CCF41343.1 - 1.3e-06 28.1 3.5 0.33 10.3 0.0 3.6 2 1 0 3 3 3 3 AAA-like domain DUF258 PF03193.11 CCF41343.1 - 1.7e-06 27.3 0.0 0.0057 15.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_25 PF13481.1 CCF41343.1 - 3.7e-06 26.4 0.1 0.3 10.4 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.1 CCF41343.1 - 3.9e-06 26.5 1.9 0.036 13.6 0.0 4.1 4 0 0 4 4 4 1 AAA domain APS_kinase PF01583.15 CCF41343.1 - 4.8e-06 26.3 0.1 0.0031 17.1 0.0 2.5 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_22 PF13401.1 CCF41343.1 - 6.5e-06 26.3 0.1 0.14 12.3 0.1 3.3 2 1 0 2 2 2 2 AAA domain AAA_18 PF13238.1 CCF41343.1 - 8.1e-06 26.1 0.0 0.041 14.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.1 CCF41343.1 - 2.3e-05 24.8 0.7 0.21 11.9 0.0 2.7 3 0 0 3 3 2 2 AAA domain AAA_33 PF13671.1 CCF41343.1 - 6.8e-05 22.7 0.1 0.12 12.2 0.0 2.8 3 0 0 3 3 2 2 AAA domain DUF87 PF01935.12 CCF41343.1 - 9.8e-05 22.2 0.0 0.16 11.7 0.0 2.7 3 0 0 3 3 3 2 Domain of unknown function DUF87 Zeta_toxin PF06414.7 CCF41343.1 - 0.00023 20.3 0.0 0.4 9.7 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin MMR_HSR1 PF01926.18 CCF41343.1 - 0.0028 17.5 0.0 1.2 9.1 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_5 PF07728.9 CCF41343.1 - 0.0033 17.1 0.2 7 6.3 0.0 3.6 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) DUF3987 PF13148.1 CCF41343.1 - 0.0098 14.4 0.0 2.6 6.4 0.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3987) ABC_ATPase PF09818.4 CCF41343.1 - 0.01 14.4 0.2 0.024 13.2 0.2 1.5 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA PF00004.24 CCF41343.1 - 0.011 15.9 0.0 50 4.0 0.0 3.5 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.17 CCF41343.1 - 0.013 14.9 0.0 0.39 10.1 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_14 PF13173.1 CCF41343.1 - 0.015 15.2 0.0 6.7 6.6 0.0 2.8 3 0 0 3 3 3 0 AAA domain ATP-synt_ab PF00006.20 CCF41343.1 - 0.021 14.3 0.1 7.4 6.0 0.0 2.6 3 0 0 3 3 2 0 ATP synthase alpha/beta family, nucleotide-binding domain MobB PF03205.9 CCF41343.1 - 0.025 14.2 0.0 4.1 7.1 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 CCF41343.1 - 0.037 14.1 0.1 7.7 6.7 0.0 3.1 3 0 0 3 3 2 0 RNA helicase G-alpha PF00503.15 CCF41343.1 - 0.094 11.3 0.0 12 4.3 0.0 2.4 2 0 0 2 2 2 0 G-protein alpha subunit NB-ARC PF00931.17 CCF41343.1 - 0.14 10.9 0.0 10 4.8 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain UvrD_C PF13361.1 CCF41346.1 - 1.7e-79 267.8 0.0 2.3e-79 267.3 0.0 1.2 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 CCF41346.1 - 3.8e-65 220.2 0.1 3e-63 214.0 0.0 2.4 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.1 CCF41346.1 - 1.5e-14 53.9 0.0 4.6e-14 52.4 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.1 CCF41346.1 - 1.7e-11 43.6 0.8 7.3e-11 41.6 0.5 2.1 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 CCF41346.1 - 1.2e-05 25.0 0.6 0.002 17.7 0.1 2.4 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.13 CCF41346.1 - 4.4e-05 23.1 0.0 0.57 9.6 0.0 3.2 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_12 PF13087.1 CCF41346.1 - 0.0015 17.9 0.0 0.021 14.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CCF41346.1 - 0.007 16.4 0.3 3.5 7.7 0.0 2.8 1 1 1 2 2 2 2 AAA domain AAA_11 PF13086.1 CCF41346.1 - 0.031 13.8 0.0 0.12 11.9 0.0 2.0 1 1 0 1 1 1 0 AAA domain Patched PF02460.13 CCF41347.1 - 8e-61 205.9 23.4 1.5e-47 162.1 1.1 3.3 3 0 0 3 3 3 3 Patched family Sterol-sensing PF12349.3 CCF41347.1 - 4.6e-51 172.2 6.3 4.6e-51 172.2 4.4 3.3 4 0 0 4 4 4 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.10 CCF41347.1 - 4.3e-05 22.3 8.1 4.3e-05 22.3 5.6 3.0 3 0 0 3 3 3 2 MMPL family Folate_rec PF03024.9 CCF41347.1 - 4.9e-05 23.0 1.6 0.00011 21.9 1.1 1.5 1 0 0 1 1 1 1 Folate receptor family PAS_9 PF13426.1 CCF41349.1 - 4.5e-18 65.5 0.0 1.2e-15 57.7 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS PF00989.19 CCF41349.1 - 0.0018 18.0 0.0 0.0073 16.0 0.0 2.0 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.5 CCF41349.1 - 0.03 14.3 0.0 0.36 10.8 0.0 2.4 2 0 0 2 2 2 0 PAS fold zf-DHHC PF01529.15 CCF41351.1 - 2.2e-30 105.3 0.2 2.2e-30 105.3 0.1 2.0 1 1 1 2 2 2 1 DHHC palmitoyltransferase DUF485 PF04341.7 CCF41351.1 - 0.36 10.5 6.8 1.9 8.2 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF485 Methyltransf_23 PF13489.1 CCF41352.1 - 5e-08 32.8 0.0 6e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF41352.1 - 0.028 14.8 0.0 0.047 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain YugN PF08868.5 CCF41353.1 - 0.065 12.8 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 YugN-like family Methyltransf_23 PF13489.1 CCF41354.1 - 3.8e-12 46.2 0.0 4.3e-12 46.0 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF41354.1 - 3.5e-07 30.7 0.1 5.4e-06 26.9 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF41354.1 - 3e-06 26.8 0.0 2.2e-05 24.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF41354.1 - 7.6e-05 23.0 0.0 0.00013 22.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF41354.1 - 0.0011 19.4 0.0 0.0092 16.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF41354.1 - 0.0019 18.6 0.0 0.0023 18.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF41354.1 - 0.0024 16.9 0.0 0.0035 16.4 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 CCF41354.1 - 0.0045 16.3 0.0 0.0049 16.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.14 CCF41354.1 - 0.0046 16.9 0.0 0.0049 16.8 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.13 CCF41354.1 - 0.0057 15.8 0.0 0.0072 15.5 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase PCMT PF01135.14 CCF41354.1 - 0.0094 15.4 0.1 0.097 12.1 0.1 1.9 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_26 PF13659.1 CCF41354.1 - 0.012 15.6 0.0 0.015 15.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.4 CCF41354.1 - 0.04 13.3 0.0 0.047 13.1 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase PrmA PF06325.8 CCF41354.1 - 0.16 11.1 0.0 0.17 10.9 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Fungal_trans PF04082.13 CCF41356.1 - 0.00013 20.9 0.0 0.00022 20.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Polysacc_deac_1 PF01522.16 CCF41357.1 - 5.4e-11 42.2 0.0 9.5e-11 41.4 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase CHASE4 PF05228.8 CCF41358.1 - 0.14 11.7 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 CHASE4 domain HTH_17 PF12728.2 CCF41361.1 - 0.1 12.8 0.1 18 5.6 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain E1-E2_ATPase PF00122.15 CCF41362.1 - 2.7e-55 186.9 5.8 5.3e-55 185.9 4.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 CCF41362.1 - 6.4e-23 82.2 0.0 1.9e-22 80.7 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 CCF41362.1 - 5.6e-13 49.4 0.0 1.6e-12 48.0 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CCF41362.1 - 0.001 18.7 0.1 0.0022 17.6 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF41362.1 - 0.033 14.1 0.0 0.06 13.3 0.0 1.4 1 0 0 1 1 1 0 Putative hydrolase of sodium-potassium ATPase alpha subunit ABM PF03992.11 CCF41363.1 - 0.00023 21.1 0.2 0.00033 20.6 0.2 1.2 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Arrestin_C PF02752.17 CCF41363.1 - 0.11 12.5 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain DUF3425 PF11905.3 CCF41365.1 - 9e-31 106.5 2.2 1.4e-30 105.9 1.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) Metal_resist PF13801.1 CCF41365.1 - 0.0015 18.5 8.2 0.0035 17.3 5.7 1.5 1 0 0 1 1 1 1 Heavy-metal resistance bZIP_1 PF00170.16 CCF41365.1 - 0.0058 16.5 12.5 0.036 14.0 8.0 2.3 1 1 1 2 2 2 1 bZIP transcription factor M PF02370.11 CCF41365.1 - 0.058 13.7 3.7 1.6 9.3 0.4 2.8 2 0 0 2 2 2 0 M protein repeat Spindle_Spc25 PF08234.7 CCF41366.1 - 2e-22 78.9 1.0 2.8e-22 78.4 0.0 1.8 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 VRP1 PF03538.9 CCF41366.1 - 0.004 16.2 1.4 0.0072 15.4 0.4 1.6 1 1 0 2 2 2 1 Salmonella virulence plasmid 28.1kDa A protein Atg14 PF10186.4 CCF41366.1 - 0.093 11.6 15.5 0.021 13.7 8.6 1.5 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF342 PF03961.8 CCF41366.1 - 0.27 9.6 7.5 0.37 9.1 5.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) THOC7 PF05615.8 CCF41366.1 - 0.41 10.9 16.4 0.064 13.5 7.9 2.1 2 1 0 2 2 2 0 Tho complex subunit 7 PRCC PF10253.4 CCF41366.1 - 1.9 9.1 10.7 3.2 8.4 7.4 1.4 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting FUSC PF04632.7 CCF41366.1 - 1.9 6.8 6.9 2.6 6.3 4.8 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Mnd1 PF03962.10 CCF41366.1 - 3.8 7.1 18.7 3.5 7.2 5.4 2.2 1 1 1 2 2 2 0 Mnd1 family V_ATPase_I PF01496.14 CCF41366.1 - 5.8 4.6 9.5 7.4 4.2 6.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ADIP PF11559.3 CCF41366.1 - 8.9 6.1 22.0 16 5.4 6.9 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding HTH_psq PF05225.11 CCF41367.1 - 3.4e-15 55.3 0.0 5.7e-15 54.6 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF41367.1 - 1.1e-10 41.1 0.1 1.7e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_28 PF13518.1 CCF41367.1 - 0.0047 16.8 0.1 0.014 15.3 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_1 PF01527.15 CCF41367.1 - 0.0053 16.6 0.0 0.016 15.1 0.0 1.8 1 1 0 1 1 1 1 Transposase HTH_23 PF13384.1 CCF41367.1 - 0.087 12.5 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain O-FucT PF10250.4 CCF41368.1 - 3e-07 29.8 0.0 8.9e-06 25.0 0.0 2.0 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Acyl-CoA_dh_1 PF00441.19 CCF41370.1 - 2e-05 24.7 0.1 2.2e-05 24.6 0.1 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Sec63 PF02889.11 CCF41371.1 - 4.9e-47 160.6 0.0 2.6e-46 158.2 0.0 1.8 1 1 0 1 1 1 1 Sec63 Brl domain Gelsolin PF00626.17 CCF41372.1 - 4.5e-10 39.0 0.0 0.0017 17.9 0.0 3.2 3 0 0 3 3 3 2 Gelsolin repeat AAR2 PF05282.6 CCF41373.1 - 1.3e-53 182.2 0.0 1.8e-53 181.7 0.0 1.1 1 0 0 1 1 1 1 AAR2 protein Baculo_p74_N PF08404.5 CCF41373.1 - 0.087 11.5 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Baculoviridae P74 N-terminal DUF544 PF04424.8 CCF41374.1 - 5.9e-12 45.4 0.0 1e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF544) MFS_1 PF07690.11 CCF41375.1 - 6.4e-14 51.4 11.7 6.4e-14 51.4 8.1 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.3 CCF41375.1 - 0.0019 16.7 7.0 0.0022 16.5 2.8 2.0 2 0 0 2 2 2 1 Vacuole effluxer Atg22 like TauE PF01925.14 CCF41375.1 - 0.2 11.0 17.2 0.66 9.3 0.6 3.2 2 1 0 3 3 3 0 Sulfite exporter TauE/SafE DUF3328 PF11807.3 CCF41376.1 - 2.4e-11 43.7 1.9 1.7e-10 40.9 1.3 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) 2OG-FeII_Oxy PF03171.15 CCF41378.1 - 8.2e-14 51.7 0.0 1.5e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 CCF41378.1 - 0.018 15.5 0.0 0.034 14.6 0.0 1.4 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal CNH PF00780.17 CCF41379.1 - 7.5e-25 87.8 0.0 9.5e-25 87.5 0.0 1.1 1 0 0 1 1 1 1 CNH domain MFS_1 PF07690.11 CCF41380.1 - 7.9e-18 64.2 26.7 7.9e-18 64.2 18.5 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily NUDIX PF00293.23 CCF41381.1 - 1.4e-18 66.8 0.6 3.2e-18 65.6 0.1 1.6 2 0 0 2 2 2 1 NUDIX domain NUDIX PF00293.23 CCF41382.1 - 1.1e-06 28.2 0.0 1.7e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Abhydrolase_1 PF00561.15 CCF41383.1 - 8.9e-19 67.9 0.0 1.3e-17 64.1 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF41383.1 - 1.9e-12 47.5 3.2 1.2e-11 44.9 2.2 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 CCF41383.1 - 0.00033 20.1 0.0 0.00056 19.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase IFP_35_N PF07334.8 CCF41385.1 - 0.066 13.1 0.4 0.1 12.5 0.3 1.3 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus EVI2A PF05399.6 CCF41386.1 - 0.11 11.7 0.2 0.16 11.2 0.1 1.1 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) DAG1 PF05454.6 CCF41386.1 - 0.23 10.5 1.1 0.32 10.1 0.8 1.1 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) CPSF_A PF03178.10 CCF41387.1 - 0.00012 21.2 0.0 0.0017 17.5 0.0 2.5 3 0 0 3 3 3 1 CPSF A subunit region WD40 PF00400.27 CCF41387.1 - 0.00022 20.9 1.3 0.42 10.5 0.0 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat p450 PF00067.17 CCF41389.1 - 9.8e-25 86.9 0.0 1.2e-24 86.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Phage_Treg PF04761.7 CCF41389.1 - 0.11 12.2 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 Lactococcus bacteriophage putative transcription regulator AA_permease_2 PF13520.1 CCF41390.1 - 2.1e-19 69.4 3.2 2.5e-19 69.1 2.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF41390.1 - 9.8e-11 40.6 2.6 1.1e-10 40.4 1.8 1.0 1 0 0 1 1 1 1 Amino acid permease peroxidase PF00141.18 CCF41391.1 - 3.9e-85 284.9 0.0 2.9e-45 154.5 0.0 2.3 2 0 0 2 2 2 2 Peroxidase GST_C PF00043.20 CCF41391.1 - 0.018 14.9 0.0 1.1 9.2 0.0 2.4 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Myb_DNA-bind_6 PF13921.1 CCF41392.1 - 0.0003 20.8 0.1 0.0028 17.7 0.2 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 CCF41392.1 - 0.027 14.5 0.1 0.27 11.3 0.3 2.3 2 0 0 2 2 2 0 Myb-like DNA-binding domain Exonuc_VIII PF06630.6 CCF41392.1 - 0.11 11.7 0.1 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Enterobacterial exodeoxyribonuclease VIII AIM24 PF01987.12 CCF41393.1 - 3.2e-50 170.5 0.8 3.6e-50 170.4 0.6 1.0 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 Helicase_C PF00271.26 CCF41395.1 - 4.4e-10 39.2 0.1 9.4e-10 38.2 0.0 1.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SH3_9 PF14604.1 CCF41396.1 - 7.8e-06 25.3 0.1 1.4e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 CCF41396.1 - 0.00021 20.6 0.0 0.00046 19.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain DUF1183 PF06682.7 CCF41396.1 - 0.0085 15.7 3.2 1.1 8.8 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1183) DUF4131 PF13567.1 CCF41396.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) DB PF01682.14 CCF41396.1 - 0.17 11.9 3.2 0.3 11.1 2.2 1.3 1 0 0 1 1 1 0 DB module IncA PF04156.9 CCF41396.1 - 0.21 11.1 2.4 0.31 10.6 1.7 1.2 1 0 0 1 1 1 0 IncA protein Gly-zipper_OmpA PF13436.1 CCF41396.1 - 0.24 11.0 8.9 2.1 8.0 2.5 2.5 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain DUF2668 PF10873.3 CCF41396.1 - 3.2 7.8 9.8 0.078 13.1 1.5 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF2668) Pkinase PF00069.20 CCF41397.1 - 5.4e-23 81.4 0.0 8.3e-23 80.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.17 CCF41397.1 - 3.5e-13 48.4 10.6 0.01 15.8 0.2 6.8 6 0 0 6 6 6 4 HEAT repeat WD40 PF00400.27 CCF41397.1 - 1.3e-11 43.9 17.4 1.5e-08 34.2 0.0 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat HEAT_2 PF13646.1 CCF41397.1 - 4.3e-09 36.5 4.9 0.012 15.8 0.0 4.4 1 1 3 4 4 4 4 HEAT repeats Pkinase_Tyr PF07714.12 CCF41397.1 - 3.3e-05 23.0 0.0 5.1e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT_EZ PF13513.1 CCF41397.1 - 0.00042 20.7 5.9 0.026 15.0 0.4 4.2 4 0 0 4 4 4 1 HEAT-like repeat Adaptin_N PF01602.15 CCF41397.1 - 0.036 12.4 0.2 0.96 7.6 0.0 2.2 2 0 0 2 2 2 0 Adaptin N terminal region LRR_9 PF14580.1 CCF41398.1 - 2.8e-50 170.2 0.0 7.6e-50 168.8 0.0 1.6 2 0 0 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.1 CCF41398.1 - 1e-12 47.6 5.1 1.8e-06 27.6 0.1 3.1 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.2 CCF41398.1 - 3.6e-10 39.2 0.1 5.7e-05 22.6 0.0 3.5 2 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 CCF41398.1 - 0.0011 18.7 0.7 7.1 7.3 0.0 4.9 5 0 0 5 5 5 1 Leucine rich repeat LRR_1 PF00560.28 CCF41398.1 - 0.0023 17.7 0.8 23 5.5 0.0 5.0 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.1 CCF41398.1 - 0.056 13.5 0.1 59 4.1 0.0 4.2 5 0 0 5 5 5 0 Leucine Rich repeat DUF4349 PF14257.1 CCF41398.1 - 0.061 12.5 2.9 0.11 11.7 2.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) RHH_1 PF01402.16 CCF41398.1 - 0.17 11.8 1.0 0.43 10.5 0.7 1.8 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family PspB PF06667.7 CCF41398.1 - 0.7 9.8 3.7 0.42 10.5 1.0 1.8 2 0 0 2 2 2 0 Phage shock protein B Glyco_hydro_42M PF08532.5 CCF41402.1 - 0.12 11.4 0.0 0.31 10.1 0.0 1.6 1 0 0 1 1 1 0 Beta-galactosidase trimerisation domain NAD_binding_10 PF13460.1 CCF41403.1 - 4.4e-22 78.9 0.0 7.1e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF41403.1 - 8.5e-07 28.4 0.0 0.0046 16.2 0.0 2.2 2 0 0 2 2 2 2 NmrA-like family 2-Hacid_dh_C PF02826.14 CCF41403.1 - 0.0035 16.5 0.0 0.27 10.3 0.0 2.3 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain adh_short PF00106.20 CCF41403.1 - 0.01 15.7 0.1 0.019 14.8 0.0 1.5 1 0 0 1 1 1 0 short chain dehydrogenase Epimerase PF01370.16 CCF41403.1 - 0.11 11.8 0.0 2.4 7.5 0.0 2.1 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family RibD_C PF01872.12 CCF41404.1 - 1.5e-18 67.1 0.0 1.7e-17 63.6 0.0 1.9 1 1 0 1 1 1 1 RibD C-terminal domain DHFR_1 PF00186.14 CCF41404.1 - 2.4e-05 23.9 0.0 2.7e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Dihydrofolate reductase DUF3433 PF11915.3 CCF41405.1 - 1.3e-31 108.6 6.9 3.3e-20 72.0 0.6 2.9 2 0 0 2 2 2 2 Protein of unknown function (DUF3433) NmrA PF05368.8 CCF41406.1 - 1e-16 60.9 0.1 1.4e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF41406.1 - 1.8e-11 44.4 0.6 2.6e-11 43.8 0.4 1.3 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF41406.1 - 0.0072 15.7 0.1 0.011 15.1 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GARS_N PF02844.10 CCF41406.1 - 0.019 15.4 0.0 0.044 14.2 0.0 1.7 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, N domain Beach PF02138.13 CCF41407.1 - 7.2e-109 363.3 0.0 1.3e-108 362.5 0.0 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 CCF41407.1 - 2.9e-11 43.1 0.0 7.4e-11 41.8 0.0 1.7 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.1 CCF41407.1 - 4.4e-11 43.2 0.0 1.1e-10 41.9 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.27 CCF41407.1 - 4.4e-08 32.6 4.0 0.00059 19.6 0.2 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat DDOST_48kD PF03345.9 CCF41409.1 - 1.8e-149 497.9 0.0 2.8e-148 493.9 0.0 1.9 1 1 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta HSDR_N_2 PF13588.1 CCF41411.1 - 0.042 13.6 0.2 0.13 12.0 0.0 1.7 2 0 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) DUF3328 PF11807.3 CCF41412.1 - 3.4e-28 98.8 0.0 4.9e-28 98.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Fungal_trans_2 PF11951.3 CCF41413.1 - 1.9e-31 109.0 0.2 2.7e-31 108.5 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41413.1 - 4.8e-06 26.3 6.7 8.8e-06 25.5 4.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tyrosinase PF00264.15 CCF41415.1 - 1.5e-16 61.2 0.4 1.8e-16 61.0 0.3 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase DUF3328 PF11807.3 CCF41416.1 - 4.2e-05 23.3 0.1 6.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.3 CCF41418.1 - 7.3e-46 156.5 0.1 8e-46 156.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) ATP1G1_PLM_MAT8 PF02038.11 CCF41419.1 - 0.034 13.1 0.5 0.062 12.3 0.3 1.3 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family ESPR PF13018.1 CCF41420.1 - 0.061 12.9 0.1 0.27 10.8 0.0 2.0 2 0 0 2 2 2 0 Extended Signal Peptide of Type V secretion system Sec61_beta PF03911.11 CCF41421.1 - 7.7e-21 73.6 1.5 1e-20 73.2 1.0 1.2 1 0 0 1 1 1 1 Sec61beta family DUF1180 PF06679.7 CCF41421.1 - 0.077 12.8 1.8 0.097 12.5 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Glyco_transf_25 PF01755.12 CCF41422.1 - 9.2e-13 48.2 0.0 4.1e-10 39.6 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase family 25 (LPS biosynthesis protein) Tup_N PF08581.5 CCF41423.1 - 0.0051 16.9 30.1 0.2 11.8 1.7 5.2 1 1 5 6 6 6 3 Tup N-terminal Mnd1 PF03962.10 CCF41423.1 - 0.0082 15.8 15.3 0.0082 15.8 10.6 4.0 1 1 3 4 4 4 1 Mnd1 family Spectrin PF00435.16 CCF41423.1 - 0.017 15.3 4.5 0.017 15.3 3.1 4.2 1 1 3 4 4 4 0 Spectrin repeat CCDC-167 PF15188.1 CCF41423.1 - 0.021 14.7 2.9 0.021 14.7 2.0 5.0 1 1 3 5 5 5 0 Coiled-coil domain-containing protein 167 rve_3 PF13683.1 CCF41423.1 - 0.14 11.7 6.9 7.4 6.1 0.1 4.4 4 1 1 5 5 5 0 Integrase core domain AIP3 PF03915.8 CCF41423.1 - 0.22 10.3 44.7 0.057 12.3 18.8 2.2 1 1 1 2 2 2 0 Actin interacting protein 3 Filament PF00038.16 CCF41423.1 - 1 8.7 50.0 2.8 7.3 6.4 3.1 1 1 2 3 3 3 0 Intermediate filament protein Tmemb_cc2 PF10267.4 CCF41423.1 - 1.5 7.3 47.1 0.29 9.6 21.2 2.2 1 1 1 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Spc7 PF08317.6 CCF41423.1 - 1.9 7.0 52.7 0.17 10.5 10.7 3.0 1 1 2 3 3 3 0 Spc7 kinetochore protein ACCA PF03255.9 CCF41423.1 - 4.1 6.9 32.9 0.3 10.6 0.8 5.2 1 1 5 7 7 7 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit TPR_MLP1_2 PF07926.7 CCF41423.1 - 8 6.2 73.9 9.1 6.0 10.0 5.1 1 1 2 3 3 2 0 TPR/MLP1/MLP2-like protein TMPIT PF07851.8 CCF41423.1 - 8.5 5.3 41.9 2.5 7.1 7.2 3.5 1 1 1 3 3 3 0 TMPIT-like protein DUF2418 PF10332.4 CCF41424.1 - 7.1e-35 119.2 0.7 1.7e-34 118.0 0.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2418) RRM_5 PF13893.1 CCF41425.1 - 0.053 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Response_reg PF00072.19 CCF41426.1 - 1.6e-06 28.0 0.0 1.6e-05 24.8 0.0 2.0 1 1 0 1 1 1 1 Response regulator receiver domain Phageshock_PspD PF09584.5 CCF41426.1 - 0.16 11.6 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 Phage shock protein PspD (Phageshock_PspD) Pyr_redox_2 PF07992.9 CCF41428.1 - 4e-28 98.6 0.0 8.4e-28 97.6 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.21 CCF41428.1 - 2.8e-14 52.4 0.0 6.3e-14 51.3 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox PF00070.22 CCF41428.1 - 3.3e-14 53.0 0.6 3.3e-14 53.0 0.4 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF41428.1 - 4.7e-07 30.0 0.2 0.0014 18.7 0.0 3.2 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Reductase_C PF14759.1 CCF41428.1 - 1.6e-05 25.0 0.0 4.4e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 Reductase C-terminal K_oxygenase PF13434.1 CCF41428.1 - 6.2e-05 22.0 0.0 0.12 11.2 0.0 2.6 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.19 CCF41428.1 - 0.0004 19.4 5.2 0.034 13.0 0.0 3.1 3 2 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 CCF41428.1 - 0.0016 18.2 4.3 0.15 11.8 0.0 3.1 3 0 0 3 3 3 2 FAD-NAD(P)-binding FAD_binding_3 PF01494.14 CCF41429.1 - 7.3e-14 51.5 0.0 7.8e-14 51.4 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF41429.1 - 9.2e-05 21.4 0.0 9.2e-05 21.4 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 CCF41429.1 - 0.0028 18.0 0.0 0.0033 17.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF41429.1 - 0.0045 16.9 0.0 0.0048 16.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF41429.1 - 0.013 15.4 0.0 0.013 15.3 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF41429.1 - 0.04 12.7 0.0 0.042 12.6 0.0 1.0 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.17 CCF41429.1 - 0.064 12.1 0.0 0.065 12.0 0.0 1.0 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 CCF41429.1 - 0.11 12.5 0.0 0.11 12.4 0.0 1.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF41429.1 - 0.15 11.0 0.0 0.17 10.9 0.0 1.0 1 0 0 1 1 1 0 Thi4 family Cutinase PF01083.17 CCF41430.1 - 9.6e-25 87.3 2.1 9.6e-25 87.3 1.5 1.5 2 0 0 2 2 2 1 Cutinase FAD_binding_2 PF00890.19 CCF41434.1 - 1.3e-69 235.0 0.2 2e-69 234.4 0.2 1.1 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.14 CCF41434.1 - 1.2e-06 27.8 0.1 4.7e-06 25.9 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.1 CCF41434.1 - 2.6e-06 27.3 0.1 8.6e-06 25.6 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF41434.1 - 3.2e-05 23.0 1.4 0.00025 20.0 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.17 CCF41434.1 - 4.9e-05 22.3 0.1 7.3e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 CCF41434.1 - 0.00038 20.5 0.0 0.0033 17.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 CCF41434.1 - 0.00058 19.0 0.0 0.00099 18.2 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 CCF41434.1 - 0.00069 18.7 0.1 0.0016 17.6 0.0 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.9 CCF41434.1 - 0.0008 19.3 0.0 0.0019 18.0 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF41434.1 - 0.0029 16.1 0.1 0.006 15.0 0.1 1.5 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.22 CCF41434.1 - 0.014 15.7 0.1 2.4 8.6 0.0 3.2 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF41434.1 - 0.091 12.5 0.1 0.27 11.0 0.0 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.7 CCF41434.1 - 0.12 11.3 0.2 0.19 10.6 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein DUF3273 PF11677.3 CCF41435.1 - 0.16 11.1 5.2 0.11 11.7 2.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3273) Fungal_trans PF04082.13 CCF41436.1 - 6.8e-20 71.0 0.9 1.3e-19 70.0 0.6 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41436.1 - 3e-06 27.0 6.1 5.9e-06 26.0 4.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.7 CCF41436.1 - 7.6 6.7 12.1 0.98 9.6 2.9 2.3 1 1 1 2 2 2 0 Dickkopf N-terminal cysteine-rich region ATP-grasp_4 PF13535.1 CCF41437.1 - 6.5e-14 52.0 0.0 1.6e-13 50.8 0.0 1.7 1 1 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 CCF41437.1 - 8.4e-11 41.6 0.0 1.2e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.1 CCF41437.1 - 0.00026 19.8 0.0 0.00082 18.2 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.9 CCF41437.1 - 0.00038 20.3 0.0 0.00055 19.8 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.12 CCF41437.1 - 0.0031 16.8 0.0 0.0039 16.5 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain GARS_A PF01071.14 CCF41437.1 - 0.017 14.6 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_ST PF14397.1 CCF41437.1 - 0.11 11.5 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp Ins134_P3_kin PF05770.6 CCF41437.1 - 0.11 11.4 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 Inositol 1, 3, 4-trisphosphate 5/6-kinase RimK PF08443.6 CCF41437.1 - 0.14 11.6 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 RimK-like ATP-grasp domain TPR_11 PF13414.1 CCF41438.1 - 0.002 17.7 0.0 0.0061 16.1 0.0 1.8 1 0 0 1 1 1 1 TPR repeat Ribosomal_L18ae PF01775.12 CCF41439.1 - 4.8e-58 194.4 0.4 6e-58 194.1 0.3 1.1 1 0 0 1 1 1 1 Ribosomal L18ae/LX protein domain Phytase PF02333.10 CCF41441.1 - 2.4e-41 141.7 0.2 2.7e-41 141.5 0.1 1.0 1 0 0 1 1 1 1 Phytase RicinB_lectin_2 PF14200.1 CCF41441.1 - 0.13 12.6 0.0 0.59 10.5 0.0 2.1 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like Sugar_tr PF00083.19 CCF41445.1 - 9.7e-82 274.9 24.8 1.2e-81 274.6 17.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF41445.1 - 7.2e-20 70.9 34.5 3.8e-17 62.0 21.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily ABC2_membrane_2 PF12679.2 CCF41445.1 - 0.29 9.9 11.5 0.66 8.7 8.0 1.6 1 0 0 1 1 1 0 ABC-2 family transporter protein MOSC_N PF03476.11 CCF41446.1 - 4.6e-11 42.4 0.0 1.4e-10 40.9 0.0 1.9 1 1 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.12 CCF41446.1 - 4.8e-08 32.5 0.0 8.7e-08 31.7 0.0 1.5 1 1 0 1 1 1 1 MOSC domain Rad10 PF03834.9 CCF41448.1 - 9.9e-31 105.2 0.0 1.6e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.1 CCF41448.1 - 0.00014 21.9 0.0 0.00034 20.7 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain DUF1643 PF07799.7 CCF41448.1 - 0.11 12.2 0.3 0.56 9.8 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1643) AA_permease PF00324.16 CCF41450.1 - 5.8e-34 117.2 6.7 7e-34 116.9 4.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF41450.1 - 1.9e-10 39.8 5.1 2.3e-10 39.5 3.5 1.1 1 0 0 1 1 1 1 Amino acid permease T_cell_tran_alt PF15128.1 CCF41450.1 - 0.73 9.3 3.8 0.14 11.5 0.2 1.7 2 0 0 2 2 2 0 T-cell leukemia translocation-altered CD20 PF04103.10 CCF41450.1 - 1.1 9.1 6.0 3.7 7.4 4.1 1.8 1 1 0 1 1 1 0 CD20-like family PIG-P PF08510.7 CCF41450.1 - 2.6 7.7 6.6 0.16 11.5 0.3 2.1 1 1 1 2 2 2 0 PIG-P bZIP_1 PF00170.16 CCF41452.1 - 0.0024 17.7 5.8 0.0046 16.8 4.0 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 CCF41452.1 - 0.0065 16.2 9.2 0.042 13.6 6.3 2.1 1 1 0 1 1 1 1 Basic region leucine zipper Peptidase_C14 PF00656.17 CCF41453.1 - 0.0073 16.0 0.0 0.0083 15.8 0.0 1.1 1 0 0 1 1 1 1 Caspase domain DUF4315 PF14193.1 CCF41453.1 - 0.053 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4315) ATX_III PF08098.6 CCF41453.1 - 1.6 8.6 4.2 2.4 8.0 2.9 1.2 1 0 0 1 1 1 0 Anemonia sulcata toxin III family DUF3435 PF11917.3 CCF41454.1 - 1.8e-107 359.6 0.1 5.9e-107 357.9 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF3435) zf-C2H2 PF00096.21 CCF41454.1 - 2.1 8.8 7.4 0.9 10.0 0.9 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type SLX9 PF15341.1 CCF41455.1 - 0.5 10.8 5.3 0.85 10.0 3.7 1.4 1 1 0 1 1 1 0 Ribosome biogenesis protein SLX9 PRP38 PF03371.10 CCF41456.1 - 2.3e-59 199.9 0.0 2.9e-59 199.5 0.0 1.1 1 0 0 1 1 1 1 PRP38 family DUF1509 PF07420.6 CCF41456.1 - 0.03 13.6 9.5 0.039 13.2 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) PRP38_assoc PF12871.2 CCF41456.1 - 0.064 13.7 20.2 0.18 12.3 14.0 1.8 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term RRP7 PF12923.2 CCF41456.1 - 0.19 11.7 4.1 0.091 12.7 0.7 1.9 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) Corona_nucleoca PF00937.13 CCF41456.1 - 4.3 6.1 10.2 6 5.7 7.1 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein CDC45 PF02724.9 CCF41456.1 - 4.4 5.2 10.5 5.6 4.8 7.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Amidase PF01425.16 CCF41457.1 - 1.2e-31 110.0 0.0 1.4e-31 109.8 0.0 1.1 1 0 0 1 1 1 1 Amidase Ank_4 PF13637.1 CCF41458.1 - 9.7e-15 54.6 1.6 2.4e-07 31.0 0.0 4.6 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 CCF41458.1 - 7.3e-13 48.6 0.3 0.00092 19.5 0.0 3.3 1 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.25 CCF41458.1 - 3.5e-12 45.4 1.0 9.3e-06 25.2 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 CCF41458.1 - 1.2e-10 41.3 0.1 0.0016 18.6 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF41458.1 - 1.2e-10 40.5 0.2 0.00032 20.6 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat KilA-N PF04383.8 CCF41458.1 - 2.5e-05 23.8 1.0 0.00015 21.3 0.1 2.4 2 1 0 2 2 2 1 KilA-N domain Peptidase_S10 PF00450.17 CCF41459.1 - 1.1e-16 61.0 0.0 1.2e-16 60.9 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase BTB PF00651.26 CCF41460.1 - 4.2e-07 29.9 0.0 1.1e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain PROL5-SMR PF15621.1 CCF41460.1 - 2.8 8.4 7.1 2.6 8.5 1.9 2.2 2 0 0 2 2 2 0 Proline-rich submaxillary gland androgen-regulated family Abhydrolase_6 PF12697.2 CCF41463.1 - 5.2e-14 52.6 0.4 8.7e-14 51.9 0.3 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF41463.1 - 5e-07 29.5 0.3 1.4e-06 28.1 0.2 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family ADH_zinc_N PF00107.21 CCF41464.1 - 2.7e-19 69.0 0.2 3.5e-19 68.6 0.1 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF41464.1 - 2.7e-08 34.7 0.0 5.7e-08 33.7 0.0 1.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Epimerase PF01370.16 CCF41464.1 - 0.003 17.0 0.2 0.0039 16.6 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 CCF41464.1 - 0.056 12.6 0.1 0.073 12.3 0.1 1.2 1 0 0 1 1 1 0 NmrA-like family AlaDh_PNT_C PF01262.16 CCF41464.1 - 0.067 12.7 0.3 0.16 11.4 0.2 1.7 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DXP_reductoisom PF02670.11 CCF41464.1 - 0.082 13.4 0.1 0.12 12.9 0.0 1.2 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase adh_short PF00106.20 CCF41464.1 - 0.096 12.5 0.2 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase MOSC PF03473.12 CCF41465.1 - 4.8e-14 51.9 0.0 8.5e-14 51.1 0.0 1.4 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.11 CCF41465.1 - 2.1e-12 46.7 0.0 1.9e-11 43.7 0.0 2.3 3 0 0 3 3 3 1 MOSC N-terminal beta barrel domain SMC_N PF02463.14 CCF41466.1 - 6.1e-71 238.1 0.4 5.4e-70 235.0 0.3 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 CCF41466.1 - 3.2e-22 78.7 1.4 9.9e-22 77.1 0.2 2.6 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 CCF41466.1 - 6.7e-14 52.5 2.3 4.4e-06 26.8 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_23 PF13476.1 CCF41466.1 - 5.9e-10 39.8 24.6 5.9e-10 39.8 17.0 7.0 2 2 1 3 3 3 1 AAA domain Reo_sigmaC PF04582.7 CCF41466.1 - 9.1e-09 34.9 40.2 1.4e-05 24.4 1.4 7.0 3 2 4 8 8 8 4 Reovirus sigma C capsid protein AAA_29 PF13555.1 CCF41466.1 - 8e-05 22.0 0.0 0.00018 20.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain GAS PF13851.1 CCF41466.1 - 0.00053 19.2 8.8 0.00053 19.2 6.1 8.0 2 2 4 7 7 7 2 Growth-arrest specific micro-tubule binding ABC_tran PF00005.22 CCF41466.1 - 0.13 12.5 0.0 0.13 12.5 0.0 6.0 4 2 0 4 4 4 0 ABC transporter PGM_PMM_III PF02880.11 CCF41469.1 - 3.9e-25 88.0 0.0 7e-25 87.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.11 CCF41469.1 - 4.8e-13 49.3 0.0 1.1e-12 48.1 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 CCF41469.1 - 7.2e-09 35.5 0.0 1.4e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Aa_trans PF01490.13 CCF41470.1 - 1.1e-80 271.0 17.3 1.4e-80 270.8 12.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Claudin_2 PF13903.1 CCF41470.1 - 0.0024 17.5 5.0 0.012 15.3 0.0 3.3 4 1 0 5 5 5 1 PMP-22/EMP/MP20/Claudin tight junction Nucleoplasmin PF03066.10 CCF41470.1 - 0.13 11.7 6.2 0.062 12.8 0.6 2.1 2 0 0 2 2 2 0 Nucleoplasmin Sigma70_ner PF04546.8 CCF41470.1 - 0.47 10.0 4.9 0.38 10.3 0.4 2.0 2 0 0 2 2 2 0 Sigma-70, non-essential region NOA36 PF06524.7 CCF41470.1 - 1.7 7.8 5.6 0.38 9.9 0.4 1.9 2 0 0 2 2 2 0 NOA36 protein CAAD PF14159.1 CCF41470.1 - 6.1 6.5 6.6 1 9.0 1.0 2.6 2 0 0 2 2 2 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase Velvet PF11754.3 CCF41474.1 - 1.8e-46 158.3 0.1 1.8e-46 158.3 0.1 2.7 1 1 1 2 2 2 1 Velvet factor Trp_leader2 PF08056.6 CCF41474.1 - 0.14 12.1 1.6 0.33 10.9 1.1 1.6 1 0 0 1 1 1 0 Tryptophan operon leader peptide PAT1 PF09770.4 CCF41474.1 - 0.3 9.2 29.2 0.39 8.9 20.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Pex16 PF08610.5 CCF41474.1 - 3.3 6.6 13.1 5 6.0 9.1 1.2 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) DUF3464 PF11947.3 CCF41474.1 - 4.5 6.7 5.7 6.9 6.1 4.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) Glyco_hydro_11 PF00457.12 CCF41475.1 - 2.2e-40 137.9 14.3 2.6e-40 137.7 9.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 Ribosomal_S7 PF00177.16 CCF41477.1 - 4.7e-23 81.4 0.0 8.8e-23 80.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e EOS1 PF12326.3 CCF41478.1 - 6.5e-25 87.5 6.3 1.2e-20 73.6 1.0 2.1 1 1 1 2 2 2 2 N-glycosylation protein FA_desaturase PF00487.19 CCF41478.1 - 0.25 10.7 6.8 0.076 12.4 0.4 2.2 2 0 0 2 2 2 0 Fatty acid desaturase SUI1 PF01253.17 CCF41479.1 - 1.3e-28 98.6 5.9 1.7e-28 98.2 4.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 Cas_Csa5 PF09702.5 CCF41479.1 - 0.16 12.0 0.2 0.23 11.5 0.1 1.3 1 1 0 1 1 1 0 CRISPR-associated protein (Cas_Csa5) Ank_2 PF12796.2 CCF41480.1 - 1.2e-45 153.7 0.0 4.9e-18 65.2 0.1 5.6 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 CCF41480.1 - 2.2e-35 118.7 14.0 6.9e-07 28.7 0.0 9.5 10 0 0 10 10 10 5 Ankyrin repeat Ank_4 PF13637.1 CCF41480.1 - 1.4e-29 101.9 1.0 1.7e-09 37.9 0.1 9.0 5 1 4 9 9 9 6 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF41480.1 - 1.8e-28 97.9 7.2 1.7e-10 40.7 0.2 9.2 6 2 4 10 10 10 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF41480.1 - 3.3e-26 88.7 9.8 0.0034 17.4 0.0 10.4 11 0 0 11 11 11 7 Ankyrin repeat TPR_2 PF07719.12 CCF41481.1 - 0.071 13.0 0.4 0.071 13.0 0.3 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat KTI12 PF08433.5 CCF41483.1 - 6.3e-62 209.2 0.0 1.5e-61 207.9 0.0 1.6 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.1 CCF41483.1 - 0.0066 17.2 0.9 0.028 15.2 0.6 2.3 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CCF41483.1 - 0.021 14.6 5.2 0.022 14.6 2.5 1.9 2 1 0 2 2 2 0 AAA domain Mucin PF01456.12 CCF41483.1 - 0.029 14.1 12.6 0.27 11.0 3.0 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein AAA_18 PF13238.1 CCF41483.1 - 0.061 13.6 0.0 0.18 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain Sigma70_ner PF04546.8 CCF41483.1 - 6 6.4 7.2 11 5.5 5.0 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region PAP1 PF08601.5 CCF41485.1 - 0.14 11.8 5.3 0.18 11.4 3.7 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Lactamase_B PF00753.22 CCF41486.1 - 9.1e-14 51.5 0.2 1.2e-13 51.1 0.2 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CCF41486.1 - 7.1e-06 25.7 0.0 1.2e-05 24.9 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lipase_GDSL PF00657.17 CCF41487.1 - 2.6e-13 50.3 0.2 3.7e-13 49.8 0.1 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.1 CCF41487.1 - 6.3e-10 39.4 2.5 1e-09 38.8 1.8 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Creatinase_N PF01321.13 CCF41487.1 - 0.072 13.5 0.0 0.12 12.8 0.0 1.3 1 0 0 1 1 1 0 Creatinase/Prolidase N-terminal domain Tad PF13400.1 CCF41488.1 - 1.6 8.8 0.0 1.6 8.8 0.0 3.2 4 0 0 4 4 4 0 Putative Flp pilus-assembly TadE/G-like Abhydrolase_6 PF12697.2 CCF41490.1 - 8.7e-37 127.1 0.1 1e-36 126.9 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF41490.1 - 2.2e-27 96.1 0.0 3.6e-27 95.4 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF41490.1 - 2.2e-21 76.1 0.0 7.6e-20 71.1 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF41490.1 - 4e-07 29.4 0.1 0.023 13.9 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Ndr PF03096.9 CCF41490.1 - 5.9e-06 24.9 0.0 7.2e-06 24.6 0.0 1.1 1 0 0 1 1 1 1 Ndr family Abhydrolase_3 PF07859.8 CCF41490.1 - 1e-05 25.2 0.1 3.5e-05 23.4 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.5 CCF41490.1 - 0.00024 20.9 0.0 0.00047 20.0 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Hydrolase_4 PF12146.3 CCF41490.1 - 0.00048 19.9 0.1 0.0011 18.7 0.0 1.7 1 0 0 1 1 1 1 Putative lysophospholipase FSH1 PF03959.8 CCF41490.1 - 0.0039 16.6 0.0 0.0066 15.9 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Thioesterase PF00975.15 CCF41490.1 - 0.075 13.2 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain AXE1 PF05448.7 CCF41490.1 - 0.079 11.4 0.1 2.1 6.7 0.0 2.6 2 1 1 3 3 3 0 Acetyl xylan esterase (AXE1) UPF0227 PF05728.7 CCF41490.1 - 0.13 11.9 0.0 0.29 10.8 0.0 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Fungal_trans PF04082.13 CCF41491.1 - 7.2e-19 67.6 0.1 1.1e-18 67.0 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ribonuclease_T2 PF00445.13 CCF41495.1 - 3.8e-27 95.1 0.7 6.1e-27 94.4 0.5 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family BTB PF00651.26 CCF41496.1 - 0.00024 21.0 0.0 0.00034 20.5 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain PH PF00169.24 CCF41497.1 - 5.2e-10 39.4 0.0 1.1e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 PH domain Prominin PF05478.6 CCF41497.1 - 0.28 8.6 0.1 0.4 8.1 0.1 1.1 1 0 0 1 1 1 0 Prominin Ribosomal_L15e PF00827.12 CCF41498.1 - 1.1e-90 302.2 11.2 1.3e-90 302.0 7.8 1.0 1 0 0 1 1 1 1 Ribosomal L15 Codanin-1_C PF15296.1 CCF41498.1 - 0.13 12.1 0.1 0.24 11.2 0.0 1.5 1 1 0 1 1 1 0 Codanin-1 C-terminus MoeA_N PF03453.12 CCF41499.1 - 0.17 11.2 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 MoeA N-terminal region (domain I and II) N_NLPC_P60 PF12912.2 CCF41499.1 - 0.19 11.8 1.5 0.33 11.0 0.3 1.8 2 0 0 2 2 2 0 NLPC_P60 stabilising domain, N term RED_N PF07808.8 CCF41500.1 - 6.4e-08 32.1 13.0 6.4e-08 32.1 9.0 2.8 2 1 0 2 2 2 1 RED-like protein N-terminal region PYST-C1 PF09690.5 CCF41500.1 - 0.022 14.3 0.1 0.022 14.3 0.1 2.7 2 0 0 2 2 2 0 Plasmodium yoelii subtelomeric region (PYST-C1) DUF3328 PF11807.3 CCF41500.1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) IU_nuc_hydro PF01156.14 CCF41501.1 - 2.7e-86 289.6 0.1 3.1e-86 289.4 0.1 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DUF296 PF03479.10 CCF41501.1 - 0.035 13.7 0.0 3.8 7.1 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF296) Mito_carr PF00153.22 CCF41502.1 - 9.4e-68 223.9 0.8 3.4e-22 77.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Sod_Fe_C PF02777.13 CCF41504.1 - 1.3e-10 41.0 0.0 8.4e-05 22.3 0.0 2.4 1 1 1 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 CCF41504.1 - 0.0078 16.4 0.1 0.012 15.8 0.1 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain F-box-like PF12937.2 CCF41505.1 - 0.0024 17.5 0.0 0.018 14.7 0.0 2.5 2 1 0 2 2 2 1 F-box-like Retinal PF15449.1 CCF41505.1 - 2.6 5.6 11.2 3.6 5.1 7.8 1.1 1 0 0 1 1 1 0 Retinal protein Myosin_HC-like PF07058.6 CCF41506.1 - 0.31 10.0 7.6 0.51 9.3 5.3 1.5 1 1 0 1 1 1 0 Myosin II heavy chain-like NUP50 PF08911.6 CCF41506.1 - 5.4 7.4 8.2 0.47 10.8 1.7 2.3 2 0 0 2 2 2 0 NUP50 (Nucleoporin 50 kDa) MFS_1 PF07690.11 CCF41508.1 - 1.8e-28 99.2 10.8 2e-28 99.1 7.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily ApbA PF02558.11 CCF41509.1 - 5.2e-32 110.3 0.0 6.9e-32 109.9 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.6 CCF41509.1 - 2.6e-30 104.9 0.0 3.7e-30 104.4 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ThiF PF00899.16 CCF41509.1 - 0.064 13.0 0.5 0.2 11.4 0.0 1.9 1 1 1 2 2 2 0 ThiF family Amidohydro_4 PF13147.1 CCF41510.1 - 1.2e-09 38.6 12.4 1.3e-08 35.2 5.7 3.3 2 1 0 2 2 2 1 Amidohydrolase Amidohydro_5 PF13594.1 CCF41510.1 - 1.4e-07 31.2 3.7 1.2e-05 24.9 0.1 3.2 3 0 0 3 3 3 2 Amidohydrolase Amidohydro_1 PF01979.15 CCF41510.1 - 6.9e-05 22.6 3.1 0.00015 21.5 0.1 2.6 2 1 0 2 2 2 1 Amidohydrolase family Amidohydro_3 PF07969.6 CCF41510.1 - 0.0045 16.2 0.1 0.0045 16.2 0.1 1.9 2 1 0 2 2 2 1 Amidohydrolase family Med26 PF08711.6 CCF41511.1 - 9.6e-12 44.2 0.0 1.7e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Brr6_like_C_C PF10104.4 CCF41512.1 - 2.5e-29 101.5 4.3 3e-29 101.2 2.9 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain PgaD PF13994.1 CCF41512.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 PgaD-like protein PBP1_TM PF14812.1 CCF41512.1 - 0.48 10.7 6.9 10 6.5 4.8 2.2 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Tropomyosin PF00261.15 CCF41513.1 - 0.004 16.2 5.2 0.0044 16.1 3.6 1.0 1 0 0 1 1 1 1 Tropomyosin Cortex-I_coil PF09304.5 CCF41513.1 - 0.017 15.1 4.4 0.019 14.9 3.0 1.1 1 0 0 1 1 1 0 Cortexillin I, coiled coil SPT2 PF08243.6 CCF41513.1 - 0.02 15.1 1.3 0.025 14.9 0.9 1.1 1 0 0 1 1 1 0 SPT2 chromatin protein KID PF02524.9 CCF41513.1 - 0.086 12.9 0.4 0.35 11.1 0.3 2.1 1 0 0 1 1 1 0 KID repeat IncA PF04156.9 CCF41513.1 - 0.17 11.4 4.6 0.19 11.3 3.2 1.1 1 0 0 1 1 1 0 IncA protein DUF244 PF03112.9 CCF41513.1 - 0.24 10.9 4.9 0.84 9.1 3.4 1.8 1 1 0 1 1 1 0 Uncharacterized protein family (ORF7) DUF FlaC_arch PF05377.6 CCF41513.1 - 0.55 10.1 3.5 2.1 8.3 0.2 2.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) HR1 PF02185.11 CCF41513.1 - 0.88 9.3 8.1 1.3 8.7 4.0 2.0 1 1 1 2 2 2 0 Hr1 repeat IFP_35_N PF07334.8 CCF41513.1 - 3.9 7.5 9.1 4.4 7.3 0.5 2.3 1 1 1 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus HMG_box_2 PF09011.5 CCF41514.1 - 4.1e-12 46.3 7.6 2.9e-09 37.1 0.3 3.2 3 0 0 3 3 3 2 HMG-box domain HMG_box PF00505.14 CCF41514.1 - 1.7e-05 25.0 3.5 1.7e-05 25.0 2.5 3.4 2 2 0 2 2 2 1 HMG (high mobility group) box DUF3275 PF11679.3 CCF41514.1 - 2.8 7.5 8.2 0.18 11.3 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3275) 3Beta_HSD PF01073.14 CCF41516.1 - 8.3e-68 228.0 0.0 9.8e-68 227.8 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 CCF41516.1 - 1.9e-32 112.6 0.7 3.5e-32 111.7 0.2 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 CCF41516.1 - 4e-17 62.0 0.5 6.7e-17 61.3 0.3 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 CCF41516.1 - 2e-14 53.0 0.7 1.1e-11 44.1 0.1 2.1 1 1 1 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.1 CCF41516.1 - 2.1e-11 44.1 0.6 3.1e-11 43.6 0.4 1.3 1 0 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 CCF41516.1 - 7.3e-07 28.3 1.7 2e-06 26.9 1.2 1.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 CCF41516.1 - 2e-06 27.8 2.9 4.4e-06 26.7 2.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase DapB_N PF01113.15 CCF41516.1 - 0.00062 19.6 0.6 0.0011 18.8 0.4 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus KR PF08659.5 CCF41516.1 - 0.0022 17.6 5.4 0.016 14.8 3.7 2.1 1 1 0 1 1 1 1 KR domain NAD_binding_3 PF03447.11 CCF41516.1 - 0.0036 17.6 0.2 0.0064 16.8 0.2 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain RhoGAP PF00620.22 CCF41517.1 - 2.3e-36 124.6 0.0 4.9e-36 123.6 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.17 CCF41517.1 - 9e-31 105.7 42.9 5.9e-12 45.4 4.1 5.0 5 0 0 5 5 5 4 LIM domain NRDE-2 PF08424.5 CCF41517.1 - 1.1 8.0 5.7 2.4 6.9 3.9 1.5 1 0 0 1 1 1 0 NRDE-2, necessary for RNA interference EutQ PF06249.7 CCF41518.1 - 2.9e-10 39.9 0.0 4.9e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_3 PF05899.7 CCF41518.1 - 6.2e-09 35.1 0.0 1.1e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_2 PF07883.6 CCF41518.1 - 2.1e-05 23.9 0.0 3.1e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.2 CCF41518.1 - 0.0054 16.3 0.0 0.0087 15.6 0.0 1.3 1 1 0 1 1 1 1 Cupin Cupin_1 PF00190.17 CCF41518.1 - 0.12 11.7 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Cupin Med3 PF11593.3 CCF41518.1 - 8.4 5.5 9.8 8.8 5.4 6.8 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF3445 PF11927.3 CCF41519.1 - 9.2e-78 261.0 0.0 1.2e-77 260.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Glyco_hydro_71 PF03659.9 CCF41521.1 - 8.7e-142 472.1 8.4 8.7e-142 472.1 5.8 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 71 Pkinase PF00069.20 CCF41522.1 - 1.3e-41 142.5 0.0 1.7e-41 142.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF41522.1 - 3.7e-22 78.6 0.0 5.2e-22 78.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF41522.1 - 8.7e-05 21.6 0.0 0.00014 20.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CCF41522.1 - 0.0073 16.0 0.4 0.0073 16.0 0.3 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 CCF41522.1 - 0.025 13.6 0.0 0.043 12.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 CCF41522.1 - 0.18 10.5 0.0 0.34 9.6 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Chitin_bind_1 PF00187.14 CCF41523.1 - 3.4e-16 58.9 91.4 1.5e-08 34.4 13.3 5.1 4 1 0 4 4 4 3 Chitin recognition protein Peroxidase_2 PF01328.12 CCF41524.1 - 2.4e-30 105.2 0.0 3.1e-30 104.9 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 YjeF_N PF03853.10 CCF41525.1 - 1e-33 116.3 0.0 1.2e-33 116.0 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus MIP PF00230.15 CCF41526.1 - 6.5e-43 146.8 9.2 7.8e-43 146.5 6.4 1.1 1 0 0 1 1 1 1 Major intrinsic protein DUF221 PF02714.10 CCF41527.1 - 2.2e-95 319.2 18.6 2.8e-95 318.9 12.9 1.1 1 0 0 1 1 1 1 Domain of unknown function DUF221 DUF4463 PF14703.1 CCF41527.1 - 0.0029 18.1 0.0 0.0053 17.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) Vps53_N PF04100.7 CCF41529.1 - 3.7e-31 108.2 2.1 4.1e-31 108.1 1.5 1.0 1 0 0 1 1 1 1 Vps53-like, N-terminal Spc7 PF08317.6 CCF41529.1 - 0.00059 18.6 2.5 0.00071 18.3 1.8 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF2450 PF10475.4 CCF41529.1 - 0.00059 18.8 1.9 0.00074 18.5 1.3 1.0 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) Flagellin_N PF00669.15 CCF41529.1 - 0.0032 17.2 6.1 0.016 15.0 0.3 2.1 1 1 1 2 2 2 1 Bacterial flagellin N-terminal helical region Uds1 PF15456.1 CCF41529.1 - 0.014 15.3 6.3 0.019 14.9 0.5 2.1 1 1 1 2 2 2 0 Up-regulated During Septation Baculo_PEP_C PF04513.7 CCF41529.1 - 0.016 14.9 2.4 0.023 14.5 1.7 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_13 PF13166.1 CCF41529.1 - 0.027 12.9 0.6 0.028 12.9 0.4 1.0 1 0 0 1 1 1 0 AAA domain DUF3919 PF13057.1 CCF41529.1 - 0.082 12.3 0.1 0.19 11.1 0.0 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3919) COG2 PF06148.6 CCF41529.1 - 0.11 12.3 4.0 0.79 9.5 2.8 2.0 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3037 PF11236.3 CCF41529.1 - 0.12 12.4 0.3 0.33 11.0 0.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3037) TPR_MLP1_2 PF07926.7 CCF41529.1 - 0.27 10.9 6.2 2.3 7.9 2.7 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Spectrin PF00435.16 CCF41529.1 - 0.35 11.1 3.2 0.75 10.1 1.3 2.1 1 1 1 2 2 2 0 Spectrin repeat DivIC PF04977.10 CCF41529.1 - 0.63 9.5 3.2 1.1 8.7 0.4 2.5 1 1 2 3 3 3 0 Septum formation initiator TMF_DNA_bd PF12329.3 CCF41529.1 - 1.7 8.5 5.8 0.73 9.6 2.1 1.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF706 PF05153.10 CCF41530.1 - 3.8e-125 416.2 0.4 5.9e-125 415.6 0.3 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF706) HD PF01966.17 CCF41530.1 - 0.026 14.5 0.0 1.3 9.0 0.0 2.5 2 0 0 2 2 2 0 HD domain Fungal_trans_2 PF11951.3 CCF41531.1 - 2.9e-07 29.4 0.7 7.8e-07 28.0 0.1 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Sugar_tr PF00083.19 CCF41532.1 - 4.5e-79 266.1 20.3 5.3e-79 265.9 14.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF41532.1 - 4.5e-17 61.8 23.9 1.2e-14 53.7 14.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4131 PF13567.1 CCF41532.1 - 0.93 8.8 0.0 0.93 8.8 0.0 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) MFS_1 PF07690.11 CCF41533.1 - 8.5e-21 74.0 10.2 9.6e-21 73.8 7.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily SpoVAB PF13782.1 CCF41533.1 - 0.036 14.0 1.5 0.058 13.3 1.0 1.4 1 0 0 1 1 1 0 Stage V sporulation protein AB Fungal_trans PF04082.13 CCF41535.1 - 7.3e-13 47.9 0.9 1.1e-12 47.3 0.6 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41535.1 - 0.0013 18.6 2.7 0.0022 17.8 1.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Med15 PF09606.5 CCF41535.1 - 2.2 6.3 27.0 0.44 8.6 15.8 1.8 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Fungal_trans PF04082.13 CCF41536.1 - 4.4e-16 58.5 0.1 6.9e-16 57.8 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF955 PF06114.8 CCF41536.1 - 0.083 12.6 0.1 0.14 11.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF955) Tim17 PF02466.14 CCF41537.1 - 1.9e-36 124.9 6.4 2.3e-36 124.6 4.5 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF543 PF04418.7 CCF41537.1 - 0.12 12.3 1.1 0.24 11.4 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF543) USP7_ICP0_bdg PF12436.3 CCF41538.1 - 1.6e-87 292.9 0.0 1.3e-85 286.6 0.0 2.4 2 1 1 3 3 3 3 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.1 CCF41538.1 - 9.3e-80 267.0 1.8 1e-74 250.5 1.7 3.5 2 1 2 4 4 4 3 Ubiquitin-specific protease C-terminal Fungal_trans PF04082.13 CCF41539.1 - 1.4e-32 112.5 0.0 2e-32 112.1 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41539.1 - 2.3e-07 30.6 10.2 2.3e-07 30.6 7.1 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.11 CCF41541.1 - 2.9e-25 88.7 18.9 2.9e-25 88.7 13.1 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1218 PF06749.7 CCF41541.1 - 0.0075 16.7 2.2 0.035 14.5 0.2 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1218) CENP-Q PF13094.1 CCF41542.1 - 3e-26 92.3 0.1 3e-26 92.3 0.1 3.5 4 1 0 4 4 4 1 CENP-Q, a CENPA-CAD centromere complex subunit ABC_tran PF00005.22 CCF41543.1 - 4.5e-49 166.2 0.5 7.7e-25 87.7 0.1 3.6 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 CCF41543.1 - 1.1e-18 68.2 0.1 0.00072 19.6 0.0 4.5 3 1 0 4 4 4 4 AAA domain SMC_N PF02463.14 CCF41543.1 - 2e-17 63.1 1.1 3.7e-06 26.3 0.1 3.9 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 CCF41543.1 - 3.9e-10 39.0 0.0 0.0011 18.4 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.1 CCF41543.1 - 6e-09 36.5 5.8 0.00016 22.1 0.1 3.0 4 0 0 4 4 2 2 AAA domain AAA_17 PF13207.1 CCF41543.1 - 7.1e-09 36.5 0.1 0.0058 17.4 0.0 3.6 3 0 0 3 3 3 2 AAA domain DUF258 PF03193.11 CCF41543.1 - 2.6e-08 33.2 0.0 0.00028 20.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 CCF41543.1 - 3.8e-08 33.5 0.0 0.00059 19.9 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_28 PF13521.1 CCF41543.1 - 2e-07 31.0 0.1 0.014 15.3 0.0 2.9 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.18 CCF41543.1 - 2.3e-07 30.7 0.0 0.0042 17.0 0.0 3.4 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_10 PF12846.2 CCF41543.1 - 1e-06 28.4 0.2 0.22 10.9 0.0 3.8 4 0 0 4 4 4 2 AAA-like domain AAA_15 PF13175.1 CCF41543.1 - 1.6e-06 27.4 8.0 0.073 12.0 0.0 4.9 3 2 0 4 4 4 2 AAA ATPase domain Dynamin_N PF00350.18 CCF41543.1 - 1.8e-06 27.8 0.0 0.0012 18.7 0.0 2.7 2 0 0 2 2 2 1 Dynamin family AAA_33 PF13671.1 CCF41543.1 - 1.9e-06 27.8 0.0 0.1 12.4 0.0 2.9 3 0 0 3 3 2 2 AAA domain SbcCD_C PF13558.1 CCF41543.1 - 3.5e-06 26.8 0.0 0.019 14.8 0.0 3.1 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit Miro PF08477.8 CCF41543.1 - 5.7e-06 26.8 0.0 0.03 14.8 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein AAA_18 PF13238.1 CCF41543.1 - 7e-06 26.3 2.1 0.14 12.5 0.0 3.8 4 0 0 4 4 2 2 AAA domain AAA PF00004.24 CCF41543.1 - 9.6e-06 25.8 0.0 0.28 11.3 0.0 4.0 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) ArgK PF03308.11 CCF41543.1 - 9.7e-06 24.5 0.1 0.1 11.3 0.0 2.4 2 0 0 2 2 2 2 ArgK protein MobB PF03205.9 CCF41543.1 - 2.5e-05 23.9 0.0 0.28 10.8 0.0 2.7 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B PduV-EutP PF10662.4 CCF41543.1 - 3.2e-05 23.4 0.1 0.077 12.4 0.0 3.2 3 1 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation AAA_13 PF13166.1 CCF41543.1 - 3.5e-05 22.5 0.2 1.1 7.6 0.0 3.5 3 1 0 3 3 3 2 AAA domain RNA_helicase PF00910.17 CCF41543.1 - 3.8e-05 23.8 0.0 0.54 10.4 0.0 3.1 3 0 0 3 3 2 2 RNA helicase NACHT PF05729.7 CCF41543.1 - 9.4e-05 22.1 0.0 0.056 13.1 0.0 2.5 2 0 0 2 2 2 1 NACHT domain Arch_ATPase PF01637.13 CCF41543.1 - 0.00014 21.6 0.1 0.59 9.7 0.0 3.0 2 1 0 2 2 2 2 Archaeal ATPase AAA_14 PF13173.1 CCF41543.1 - 0.00014 21.7 0.0 1.4 8.8 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.1 CCF41543.1 - 0.0003 20.8 0.0 0.76 9.7 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain DUF87 PF01935.12 CCF41543.1 - 0.0011 18.8 0.0 0.71 9.6 0.0 3.2 3 0 0 3 3 2 1 Domain of unknown function DUF87 cobW PF02492.14 CCF41543.1 - 0.0024 17.3 0.0 2 7.8 0.0 2.8 3 0 0 3 3 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.1 CCF41543.1 - 0.0036 16.9 0.0 5 6.6 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.1 CCF41543.1 - 0.0041 16.5 0.0 4.2 6.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain Septin PF00735.13 CCF41543.1 - 0.0049 15.9 0.0 0.65 8.9 0.0 2.4 2 0 0 2 2 2 1 Septin MutS_V PF00488.16 CCF41543.1 - 0.0049 16.2 0.1 0.64 9.3 0.0 2.4 2 0 0 2 2 2 1 MutS domain V ATP-synt_ab PF00006.20 CCF41543.1 - 0.0051 16.3 0.0 3.2 7.1 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ATP_bind_1 PF03029.12 CCF41543.1 - 0.0098 15.4 0.0 6.2 6.2 0.0 2.8 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein G-alpha PF00503.15 CCF41543.1 - 0.014 14.0 0.1 0.82 8.2 0.0 2.4 2 0 0 2 2 2 0 G-protein alpha subunit PRK PF00485.13 CCF41543.1 - 0.018 14.5 0.0 0.66 9.5 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Mg_chelatase PF01078.16 CCF41543.1 - 0.02 14.0 0.0 2.6 7.1 0.0 3.0 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 CCF41543.1 - 0.02 14.0 0.0 5.1 6.1 0.0 2.8 2 0 0 2 2 2 0 Zeta toxin T2SE PF00437.15 CCF41543.1 - 0.021 13.7 0.1 2.5 6.9 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein NB-ARC PF00931.17 CCF41543.1 - 0.028 13.3 0.0 0.39 9.5 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain FtsK_SpoIIIE PF01580.13 CCF41543.1 - 0.033 13.6 0.4 4.8 6.5 0.0 2.8 3 0 0 3 3 3 0 FtsK/SpoIIIE family Rad17 PF03215.10 CCF41543.1 - 0.037 12.7 0.0 3.6 6.1 0.0 2.2 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein DUF815 PF05673.8 CCF41543.1 - 0.061 12.2 0.0 7.8 5.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) NTPase_1 PF03266.10 CCF41543.1 - 0.062 13.0 0.0 17 5.0 0.0 2.8 2 0 0 2 2 2 0 NTPase AAA_19 PF13245.1 CCF41543.1 - 0.077 12.7 0.0 5.3 6.8 0.0 2.8 3 0 0 3 3 2 0 Part of AAA domain IstB_IS21 PF01695.12 CCF41543.1 - 0.082 12.3 0.0 12 5.3 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein Acetyltransf_3 PF13302.1 CCF41544.1 - 4.7e-25 88.4 0.0 6.7e-25 87.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 CCF41544.1 - 6.7e-09 35.8 0.2 2.6e-06 27.3 0.1 2.4 2 1 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CCF41544.1 - 1.9e-07 30.9 0.5 9.6e-07 28.7 0.3 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 CCF41544.1 - 3.8e-05 23.3 0.2 0.091 12.5 0.0 2.3 2 0 0 2 2 2 2 FR47-like protein Acetyltransf_7 PF13508.1 CCF41544.1 - 0.096 12.8 0.0 0.2 11.8 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain PALP PF00291.20 CCF41545.1 - 3.7e-08 32.9 0.5 4.1e-08 32.8 0.3 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme BiPBP_C PF06832.7 CCF41545.1 - 0.033 14.1 0.0 0.058 13.3 0.0 1.4 1 0 0 1 1 1 0 Penicillin-Binding Protein C-terminus Family MTHFR PF02219.12 CCF41546.1 - 2.6e-111 371.3 0.0 3.8e-111 370.7 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Ribonuclease_3 PF00636.21 CCF41547.1 - 3.1e-45 153.2 0.0 2e-24 86.2 0.0 3.0 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 CCF41547.1 - 1.4e-27 96.2 0.0 6.4e-12 45.5 0.0 3.7 3 0 0 3 3 3 3 Ribonuclease-III-like Dicer_dimer PF03368.9 CCF41547.1 - 7.5e-18 64.0 0.2 4.5e-16 58.4 0.1 2.8 2 0 0 2 2 2 1 Dicer dimerisation domain Helicase_C PF00271.26 CCF41547.1 - 2.5e-16 59.2 0.0 7.5e-16 57.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF41547.1 - 1.8e-12 47.4 0.2 6.1e-12 45.7 0.2 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 CCF41547.1 - 1.3e-09 37.7 0.0 3e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase dsrm PF00035.20 CCF41547.1 - 0.0074 16.8 0.9 1.8 9.2 0.4 2.8 2 0 0 2 2 2 1 Double-stranded RNA binding motif TAP42 PF04177.7 CCF41548.1 - 1.7e-98 329.7 0.0 1.9e-98 329.5 0.0 1.0 1 0 0 1 1 1 1 TAP42-like family LETM1 PF07766.8 CCF41548.1 - 0.081 11.9 0.3 1.7 7.6 0.0 2.1 2 0 0 2 2 2 0 LETM1-like protein NAD_binding_8 PF13450.1 CCF41549.1 - 1.6e-07 31.2 0.0 2e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.14 CCF41549.1 - 7.7e-07 27.6 0.0 1.1e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.1 CCF41549.1 - 1.7e-05 24.6 0.1 0.0001 22.1 0.0 1.7 1 1 1 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 CCF41549.1 - 0.00011 22.3 0.0 0.00011 22.2 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CCF41549.1 - 0.0012 18.7 0.0 0.0012 18.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF41549.1 - 0.0029 16.7 0.0 0.0034 16.5 0.0 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.19 CCF41549.1 - 0.0036 16.2 0.0 0.0036 16.2 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.19 CCF41549.1 - 0.005 15.9 0.0 0.0061 15.6 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.14 CCF41549.1 - 0.0054 15.8 0.1 0.0079 15.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 CCF41549.1 - 0.11 10.8 0.0 0.12 10.8 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein Lycopene_cycl PF05834.7 CCF41549.1 - 0.12 11.2 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein Diphthamide_syn PF01866.12 CCF41551.1 - 4.9e-52 177.0 0.0 7.9e-52 176.3 0.0 1.2 1 0 0 1 1 1 1 Putative diphthamide synthesis protein ETRAMP PF09716.5 CCF41556.1 - 0.0043 16.9 0.0 0.3 11.0 0.0 3.0 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) Med15 PF09606.5 CCF41556.1 - 1.3 7.1 48.2 1.4 7.0 33.4 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Utp14 PF04615.8 CCF41556.1 - 4.4 5.3 45.4 5.5 5.0 31.5 1.0 1 0 0 1 1 1 0 Utp14 protein adh_short PF00106.20 CCF41558.1 - 2.4e-07 30.8 0.1 3.7e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase DUF4010 PF13194.1 CCF41558.1 - 0.08 12.2 0.2 0.11 11.7 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4010) Pkinase PF00069.20 CCF41560.1 - 1.5e-24 86.5 0.0 2.2e-24 86.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF41560.1 - 5.2e-09 35.5 0.0 4.2e-08 32.5 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Chitin_synth_2 PF03142.10 CCF41561.1 - 6.1e-81 272.4 0.0 8.5e-81 271.9 0.0 1.1 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.16 CCF41561.1 - 3.2e-45 154.4 0.0 2.6e-44 151.3 0.0 2.2 1 1 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.23 CCF41561.1 - 1.4e-16 60.0 0.0 7.7e-09 35.2 0.0 3.6 2 1 1 3 3 3 2 Cytochrome b5-like Heme/Steroid binding domain Glyco_transf_21 PF13506.1 CCF41561.1 - 0.14 11.4 0.0 0.32 10.2 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 21 WD40 PF00400.27 CCF41562.1 - 8.8e-29 98.3 16.4 2.4e-08 33.5 0.0 6.9 7 1 1 8 8 8 5 WD domain, G-beta repeat eIF2A PF08662.6 CCF41562.1 - 3.6e-05 23.5 0.2 0.042 13.5 0.0 3.2 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A HIRA_B PF09453.5 CCF41562.1 - 0.32 10.6 4.8 0.096 12.2 0.7 2.2 2 0 0 2 2 2 0 HIRA B motif ABC_membrane PF00664.18 CCF41563.1 - 1.2e-22 80.6 2.9 1.4e-22 80.3 2.0 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region DUF4396 PF14342.1 CCF41563.1 - 0.19 11.8 3.3 0.52 10.4 0.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4396) ABC2_membrane_5 PF13346.1 CCF41563.1 - 0.38 10.0 6.6 3.6 6.8 0.1 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein COesterase PF00135.23 CCF41565.1 - 8.6e-85 285.4 0.0 1.1e-84 285.0 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF41565.1 - 0.00094 18.8 4.5 0.012 15.1 3.0 2.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF41565.1 - 0.0059 15.8 0.3 0.013 14.7 0.2 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Glyco_hydro_47 PF01532.15 CCF41566.1 - 5.2e-138 460.4 0.0 6e-138 460.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Abhydrolase_6 PF12697.2 CCF41570.1 - 4.2e-24 85.7 0.0 5.1e-24 85.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF41570.1 - 5e-10 39.3 0.0 1.2e-09 38.0 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF41570.1 - 8.3e-10 38.5 0.0 2e-09 37.3 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 CCF41570.1 - 0.0026 18.0 0.0 0.0042 17.3 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_2 PF02230.11 CCF41570.1 - 0.0033 16.8 0.0 0.22 10.9 0.0 3.1 2 1 2 4 4 4 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.8 CCF41570.1 - 0.034 13.7 0.0 0.051 13.1 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.15 CCF41570.1 - 0.1 11.9 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Putative esterase S-AdoMet_synt_C PF02773.11 CCF41574.1 - 4.2e-76 253.2 0.2 7.1e-76 252.5 0.1 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 CCF41574.1 - 4.3e-20 71.8 0.1 6.7e-20 71.2 0.1 1.2 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain ChW PF07538.6 CCF41576.1 - 0.25 10.9 1.1 0.5 9.9 0.2 2.0 2 0 0 2 2 2 0 Clostridial hydrophobic W PI-PLC-X PF00388.14 CCF41577.1 - 1.4e-11 44.0 0.0 2.1e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain RhoGEF PF00621.15 CCF41578.1 - 1.8e-14 54.0 0.0 2.8e-14 53.3 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain E1-E2_ATPase PF00122.15 CCF41579.1 - 3.6e-63 212.6 10.4 5.8e-63 211.9 4.0 3.1 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CCF41579.1 - 5e-45 153.2 4.4 5e-45 153.2 3.1 1.7 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CCF41579.1 - 2.7e-33 116.1 0.0 4.2e-32 112.2 0.0 2.5 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF41579.1 - 2.4e-21 75.4 0.0 6.1e-21 74.1 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 CCF41579.1 - 1.9e-18 65.6 0.0 4.5e-18 64.4 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 CCF41579.1 - 2e-16 60.7 0.0 7.2e-16 58.9 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CCF41579.1 - 1.1e-08 34.9 1.4 3.6e-06 26.7 0.6 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 CCF41579.1 - 0.007 16.6 0.0 0.018 15.2 0.0 1.7 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Proteasome PF00227.21 CCF41580.1 - 6.8e-40 136.3 0.0 8.2e-40 136.1 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit TUG-UBL1 PF11470.3 CCF41581.1 - 8.7e-25 86.4 0.1 1.9e-24 85.3 0.1 1.6 1 0 0 1 1 1 1 GLUT4 regulating protein TUG RBD PF02196.10 CCF41581.1 - 0.0022 17.7 0.1 0.0047 16.6 0.0 1.5 1 0 0 1 1 1 1 Raf-like Ras-binding domain UBX PF00789.15 CCF41581.1 - 0.0027 17.7 0.0 0.018 15.1 0.0 2.2 2 0 0 2 2 2 1 UBX domain DUF4294 PF14127.1 CCF41581.1 - 0.0087 15.6 0.0 0.023 14.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4294) RA PF00788.18 CCF41581.1 - 0.013 15.9 0.2 0.035 14.5 0.1 1.7 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain Rad60-SLD PF11976.3 CCF41581.1 - 0.092 12.4 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ribosomal_L36e PF01158.13 CCF41582.1 - 1e-40 137.6 5.0 1.2e-40 137.4 3.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e LemA PF04011.7 CCF41582.1 - 0.042 12.9 0.0 0.049 12.7 0.0 1.0 1 0 0 1 1 1 0 LemA family Lipase_3 PF01764.20 CCF41584.1 - 2.6e-31 108.1 0.0 3.7e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 CCF41584.1 - 0.00048 19.8 0.0 0.00068 19.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 CCF41584.1 - 0.00062 20.0 0.0 0.001 19.3 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.2 CCF41584.1 - 0.00075 19.4 0.0 0.001 19.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.3 CCF41584.1 - 0.0066 15.8 0.0 0.09 12.1 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2974) PGAP1 PF07819.8 CCF41584.1 - 0.021 14.4 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Translin PF01997.11 CCF41586.1 - 5.4e-11 42.4 0.0 6.2e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Translin family ApbA_C PF08546.6 CCF41586.1 - 0.0082 16.1 0.1 0.013 15.5 0.0 1.5 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal LIF_OSM PF01291.12 CCF41586.1 - 0.035 14.0 0.0 0.051 13.5 0.0 1.2 1 0 0 1 1 1 0 LIF / OSM family Fungal_trans PF04082.13 CCF41587.1 - 1e-32 113.0 0.2 1.5e-32 112.5 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41587.1 - 0.00065 19.5 1.9 0.0014 18.5 1.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ILVD_EDD PF00920.16 CCF41588.1 - 2.9e-08 32.6 0.1 3.1e-08 32.5 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family adh_short PF00106.20 CCF41589.1 - 7.2e-18 65.0 0.0 1e-17 64.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF41589.1 - 9.1e-16 58.3 0.0 9.9e-16 58.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF41589.1 - 0.0059 16.2 0.0 0.0092 15.6 0.0 1.4 1 1 0 1 1 1 1 KR domain DUF1482 PF07358.6 CCF41589.1 - 0.032 13.8 0.1 0.06 12.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1482) Ank_5 PF13857.1 CCF41590.1 - 1.2e-16 60.3 0.4 1.1e-10 41.3 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 CCF41590.1 - 2.7e-16 58.4 0.1 1.7e-11 43.3 0.2 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 CCF41590.1 - 2e-15 56.8 0.0 3.2e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF41590.1 - 1.5e-14 54.0 0.4 6.8e-08 32.8 0.0 3.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF41590.1 - 3.1e-12 45.4 0.0 2.4e-08 33.4 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat zf-C2H2_4 PF13894.1 CCF41591.1 - 0.034 14.4 19.2 0.061 13.6 0.1 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger Sina PF03145.11 CCF41591.1 - 0.1 12.2 2.3 0.15 11.7 1.6 1.2 1 0 0 1 1 1 0 Seven in absentia protein family zf-C2H2 PF00096.21 CCF41591.1 - 0.13 12.6 0.1 0.13 12.6 0.1 4.0 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CCF41591.1 - 3.1 8.2 15.2 2.7 8.4 2.0 3.6 3 1 0 3 3 3 0 Zinc-finger double domain TauD PF02668.11 CCF41592.1 - 3.8e-30 105.4 0.0 5.2e-30 104.9 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family RRM_1 PF00076.17 CCF41594.1 - 2.9e-33 113.3 0.0 2.4e-15 55.9 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF41594.1 - 7.2e-20 70.7 0.0 3e-11 43.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF41594.1 - 2e-16 59.5 0.0 1e-08 34.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CCF41594.1 - 0.0022 17.7 0.0 0.0095 15.6 0.0 1.9 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.6 CCF41594.1 - 0.0059 16.0 0.7 1 8.9 0.1 2.5 2 0 0 2 2 2 2 Ribonuclease B OB domain Tom7 PF08038.7 CCF41595.1 - 4.1e-18 64.5 0.3 4.8e-18 64.3 0.2 1.1 1 0 0 1 1 1 1 TOM7 family Mito_carr PF00153.22 CCF41596.1 - 7.6e-53 176.2 1.4 1.5e-19 69.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Fungal_trans_2 PF11951.3 CCF41597.1 - 1.7e-16 59.8 0.1 2.1e-16 59.5 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Phytase PF02333.10 CCF41599.1 - 5.1e-24 84.7 0.0 6.6e-23 81.0 0.0 2.2 2 0 0 2 2 2 1 Phytase EGF_2 PF07974.8 CCF41599.1 - 8.6e-06 25.8 34.5 0.013 15.6 8.3 2.6 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.2 CCF41599.1 - 2.6 8.3 14.5 0.87 9.8 2.0 2.8 2 0 0 2 2 2 0 Human growth factor-like EGF EGF PF00008.22 CCF41599.1 - 5.1 7.1 21.2 0.23 11.4 4.9 2.9 2 1 0 2 2 2 0 EGF-like domain BetaGal_dom2 PF10435.4 CCF41600.1 - 6.1e-59 198.4 2.1 9e-59 197.8 1.5 1.3 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom4_5 PF13364.1 CCF41600.1 - 9.5e-37 125.6 7.0 6e-19 68.3 0.6 3.3 3 1 0 3 3 3 2 Beta-galactosidase jelly roll domain BetaGal_dom3 PF13363.1 CCF41600.1 - 2e-22 78.3 0.0 1.5e-21 75.5 0.0 2.2 2 0 0 2 2 2 1 Beta-galactosidase, domain 3 Glyco_hydro_35 PF01301.14 CCF41600.1 - 1.3e-18 67.4 0.0 1.8e-18 66.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 CDC45 PF02724.9 CCF41604.1 - 0.013 13.5 1.6 0.016 13.2 1.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.7 CCF41604.1 - 1.2 6.9 5.0 1.4 6.7 3.4 1.1 1 0 0 1 1 1 0 Nop14-like family WD40 PF00400.27 CCF41605.1 - 2.4e-72 236.4 14.0 2.9e-11 42.7 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Nucleoporin_N PF08801.6 CCF41605.1 - 0.00022 20.1 0.2 0.1 11.3 0.1 3.4 1 1 2 3 3 3 2 Nup133 N terminal like Nup160 PF11715.3 CCF41605.1 - 0.0013 16.9 1.7 0.32 9.0 0.0 3.6 2 1 2 4 4 4 2 Nucleoporin Nup120/160 Nbas_N PF15492.1 CCF41605.1 - 0.0026 16.9 0.1 3.4 6.6 0.0 3.2 2 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.11 CCF41605.1 - 0.012 13.9 0.4 0.23 9.7 0.1 2.6 1 1 1 2 2 2 0 Cytochrome D1 heme domain PD40 PF07676.7 CCF41605.1 - 0.02 14.5 0.0 12 5.6 0.0 4.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Glyco_hydro_61 PF03443.9 CCF41607.1 - 5.5e-75 251.9 0.2 7.4e-75 251.4 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Ceramidase_alk PF04734.8 CCF41608.1 - 2.3e-230 766.0 0.0 2.6e-230 765.8 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase SPT6_acidic PF14632.1 CCF41609.1 - 0.031 14.4 3.9 1.1 9.4 1.7 2.5 2 0 0 2 2 2 0 Acidic N-terminal SPT6 CDC45 PF02724.9 CCF41610.1 - 0.046 11.7 2.0 0.048 11.7 1.4 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF3245 PF11595.3 CCF41610.1 - 0.11 12.7 5.4 0.13 12.4 3.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) Cwf_Cwc_15 PF04889.7 CCF41610.1 - 0.68 9.5 6.2 0.78 9.4 4.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.1 CCF41610.1 - 1.2 9.4 6.9 1.5 9.2 4.8 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SPC22 PF04573.7 CCF41611.1 - 4.4e-34 117.2 2.2 6.2e-24 84.1 0.3 2.1 2 0 0 2 2 2 2 Signal peptidase subunit DUF2366 PF10171.4 CCF41612.1 - 0.025 14.0 0.0 0.057 12.9 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2366) Mito_carr PF00153.22 CCF41614.1 - 9.9e-41 137.3 4.6 5.5e-21 74.0 0.0 2.8 3 0 0 3 3 3 2 Mitochondrial carrier protein WD40 PF00400.27 CCF41615.1 - 2.2e-18 65.3 1.1 1.5e-09 37.3 0.0 5.5 6 0 0 6 6 6 3 WD domain, G-beta repeat Nup160 PF11715.3 CCF41615.1 - 0.027 12.5 0.1 0.095 10.8 0.1 1.9 2 1 0 2 2 2 0 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 CCF41615.1 - 0.029 13.1 1.3 2.1 7.0 0.1 2.4 2 1 1 3 3 3 0 Nup133 N terminal like p450 PF00067.17 CCF41616.1 - 2.6e-06 26.2 0.0 2.9e-06 26.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 G_glu_transpept PF01019.16 CCF41617.1 - 2.2e-154 514.7 0.5 2.5e-154 514.5 0.3 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase RPE65 PF03055.10 CCF41618.1 - 9.8e-56 189.2 0.0 1.2e-55 189.0 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Sulfotransfer_3 PF13469.1 CCF41618.1 - 0.011 16.6 0.0 0.016 16.1 0.0 1.3 1 0 0 1 1 1 0 Sulfotransferase family NAD_binding_8 PF13450.1 CCF41621.1 - 4.5e-12 45.8 0.4 1.3e-11 44.3 0.3 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CCF41621.1 - 6.6e-09 35.1 3.5 1.2e-08 34.2 2.4 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF41621.1 - 3e-08 32.9 3.1 1.3e-07 30.9 1.6 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 CCF41621.1 - 1.1e-06 28.0 1.8 1.8e-06 27.3 1.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 CCF41621.1 - 6.6e-06 24.8 0.9 1.1e-05 24.0 0.6 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.9 CCF41621.1 - 3.6e-05 23.7 0.9 6.5e-05 22.8 0.6 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF41621.1 - 7.8e-05 23.0 0.3 0.00019 21.7 0.2 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF41621.1 - 8.3e-05 22.7 1.6 0.00032 20.8 0.0 2.4 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 CCF41621.1 - 0.00013 21.1 1.9 0.00021 20.4 1.1 1.5 1 1 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 CCF41621.1 - 0.00035 19.7 0.5 0.00072 18.7 0.4 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.7 CCF41621.1 - 0.00043 19.3 0.1 0.00065 18.7 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.17 CCF41621.1 - 0.0043 15.9 1.3 0.0062 15.4 0.9 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Amino_oxidase PF01593.19 CCF41621.1 - 0.0047 16.0 0.0 0.0068 15.5 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Trp_halogenase PF04820.9 CCF41621.1 - 0.051 12.1 1.5 0.086 11.4 1.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase NAD_binding_7 PF13241.1 CCF41621.1 - 0.054 13.7 0.0 0.098 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.13 CCF41621.1 - 0.07 12.7 1.1 0.17 11.4 0.5 1.8 3 0 0 3 3 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.7 CCF41621.1 - 0.11 11.8 0.3 0.19 11.1 0.2 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain AlaDh_PNT_C PF01262.16 CCF41621.1 - 0.11 12.0 0.1 0.2 11.2 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF4507 PF14964.1 CCF41623.1 - 0.047 12.4 1.1 0.081 11.6 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4507) Toxin_trans PF07952.7 CCF41623.1 - 0.11 11.4 0.8 0.14 11.0 0.6 1.1 1 0 0 1 1 1 0 Clostridium neurotoxin, Translocation domain COMPASS-Shg1 PF05205.7 CCF41623.1 - 3.6 7.9 7.5 0.3 11.3 1.0 2.1 2 1 1 3 3 3 0 COMPASS (Complex proteins associated with Set1p) component shg1 MDH PF02315.11 CCF41624.1 - 0.019 14.8 0.1 0.021 14.7 0.1 1.1 1 0 0 1 1 1 0 Methanol dehydrogenase beta subunit DUF2236 PF09995.4 CCF41625.1 - 2.8e-11 43.2 0.3 4.6e-11 42.4 0.2 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) Spc7_N PF15402.1 CCF41627.1 - 3.5e-122 409.2 49.5 1e-121 407.6 34.3 1.7 1 1 0 1 1 1 1 N-terminus of kinetochore NMS complex subunit Spc7 Ribosomal_S17 PF00366.15 CCF41628.1 - 4.5e-30 103.5 0.6 7e-30 102.8 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 Fungal_trans PF04082.13 CCF41629.1 - 2.7e-26 92.0 0.0 4.4e-26 91.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41629.1 - 3.9e-08 33.0 13.7 6.7e-08 32.3 9.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_L37ae PF01780.14 CCF41629.1 - 0.98 9.3 5.3 1.9 8.3 3.7 1.4 1 0 0 1 1 1 0 Ribosomal L37ae protein family Zn_clus PF00172.13 CCF41630.1 - 2.8e-07 30.3 11.9 4.5e-07 29.6 8.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SIS PF01380.17 CCF41631.1 - 5.3e-55 184.5 0.1 1.1e-29 102.7 0.0 2.3 2 0 0 2 2 2 2 SIS domain GATase_2 PF00310.16 CCF41631.1 - 9.2e-28 96.9 0.0 5.5e-19 68.0 0.0 2.3 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 CCF41631.1 - 9.1e-20 70.9 0.0 2.3e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 CCF41631.1 - 9.8e-12 44.7 0.0 2.3e-11 43.4 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 CCF41631.1 - 1.2e-07 30.7 0.0 1.8e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.1 CCF41631.1 - 0.027 14.1 0.0 0.31 10.7 0.0 2.4 2 0 0 2 2 2 0 SIS domain PTSIIB_sorb PF03830.10 CCF41631.1 - 0.027 14.3 0.0 0.23 11.3 0.0 2.2 2 0 0 2 2 2 0 PTS system sorbose subfamily IIB component Glyco_hydro_43 PF04616.9 CCF41632.1 - 4.1e-08 32.6 4.2 7.6e-08 31.7 2.9 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 TCRP1 PF14944.1 CCF41633.1 - 0.013 15.4 0.1 0.015 15.2 0.1 1.0 1 0 0 1 1 1 0 Tongue Cancer Chemotherapy Resistant Protein 1 Dpy-30 PF05186.8 CCF41635.1 - 4.7e-12 45.1 0.0 6.4e-12 44.7 0.0 1.2 1 0 0 1 1 1 1 Dpy-30 motif Ribosomal_S13_N PF08069.7 CCF41636.1 - 4.5e-30 103.2 0.1 8.4e-30 102.4 0.1 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.17 CCF41636.1 - 1.1e-22 79.5 0.0 1.9e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.13 CCF41636.1 - 0.018 14.7 0.2 0.044 13.5 0.0 1.7 2 0 0 2 2 2 0 'Paired box' domain RRM_1 PF00076.17 CCF41637.1 - 1.1e-33 114.6 0.3 1.2e-13 50.5 0.0 3.7 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF41637.1 - 2e-20 72.5 0.0 3e-05 23.9 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF41637.1 - 4.8e-20 71.1 0.1 5.3e-08 32.6 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CCF41637.1 - 0.11 12.2 0.0 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Serglycin PF04360.7 CCF41638.1 - 0.036 13.7 0.0 0.081 12.6 0.0 1.5 1 0 0 1 1 1 0 Serglycin Peptidase_C15 PF01470.12 CCF41639.1 - 2.5e-05 24.2 0.0 2.8e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Pyroglutamyl peptidase Fungal_trans PF04082.13 CCF41640.1 - 3.6e-12 45.7 0.0 6.2e-12 44.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain HTH_Tnp_Tc5 PF03221.11 CCF41642.1 - 0.00059 19.5 5.8 0.0017 18.1 0.1 3.7 3 2 1 4 4 4 1 Tc5 transposase DNA-binding domain Fasciclin PF02469.17 CCF41643.1 - 7.2e-42 142.4 0.0 3.4e-26 91.7 0.0 2.2 2 0 0 2 2 2 2 Fasciclin domain MFS_1 PF07690.11 CCF41645.1 - 8e-30 103.7 42.6 5.1e-29 101.0 28.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Neurensin PF14927.1 CCF41645.1 - 0.072 12.4 2.2 2.9 7.2 0.1 3.3 3 0 0 3 3 3 0 Neurensin BAR_2 PF10455.4 CCF41647.1 - 1.5e-59 201.3 0.0 2.1e-59 200.7 0.0 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.13 CCF41647.1 - 2.6e-21 76.2 0.1 2.6e-20 72.9 0.1 2.0 1 1 0 1 1 1 1 BAR domain DUF488 PF04343.8 CCF41647.1 - 0.078 13.3 0.1 0.48 10.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF488 YdjC PF04794.7 CCF41647.1 - 0.16 11.4 1.6 0.19 11.1 0.3 1.6 2 0 0 2 2 2 0 YdjC-like protein ETC_C1_NDUFA5 PF04716.9 CCF41648.1 - 8.7e-21 73.2 2.6 1.1e-20 72.8 0.6 2.2 2 0 0 2 2 2 1 ETC complex I subunit conserved region RNA_pol_I_TF PF04090.7 CCF41649.1 - 0.0008 18.7 0.0 0.0075 15.5 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase I specific initiation factor ATP-synt_B PF00430.13 CCF41649.1 - 0.13 12.0 2.7 0.74 9.6 0.5 2.2 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) TPR_6 PF13174.1 CCF41649.1 - 0.82 10.2 2.9 13 6.4 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.27 CCF41650.1 - 1.6e-11 43.5 28.6 1.8e-05 24.4 1.2 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat Fungal_trans_2 PF11951.3 CCF41652.1 - 0.00018 20.2 4.1 0.00019 20.2 2.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Glyco_hydro_17 PF00332.13 CCF41654.1 - 0.029 13.3 0.1 0.05 12.6 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 17 Fungal_trans_2 PF11951.3 CCF41655.1 - 8.3e-13 47.6 0.0 8.3e-13 47.6 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain DHDPS PF00701.17 CCF41656.1 - 3.5e-44 150.5 0.0 4.5e-44 150.1 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family HTH_Tnp_Tc5 PF03221.11 CCF41657.1 - 8.9e-14 51.0 0.1 4.1e-13 48.9 0.0 2.1 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF41657.1 - 4.5e-12 45.3 0.1 8.1e-12 44.4 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_28 PF13518.1 CCF41657.1 - 0.00053 19.9 0.2 0.0024 17.8 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 CCF41657.1 - 0.00066 19.2 0.8 0.0019 17.7 0.0 2.3 3 0 0 3 3 3 1 Homeodomain-like domain CENP-B_N PF04218.8 CCF41657.1 - 0.012 15.0 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_29 PF13551.1 CCF41657.1 - 0.052 13.6 1.3 0.15 12.2 0.5 2.1 1 1 1 2 2 2 0 Winged helix-turn helix HTH_8 PF02954.14 CCF41657.1 - 0.14 11.6 0.4 0.58 9.7 0.0 2.1 1 1 1 2 2 2 0 Bacterial regulatory protein, Fis family PS-DH PF14765.1 CCF41658.1 - 1.1e-20 74.0 0.0 1.7e-20 73.3 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase ADH_zinc_N PF00107.21 CCF41658.1 - 1.8e-19 69.5 0.1 1.6e-18 66.5 0.1 2.6 3 0 0 3 3 3 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.7 CCF41658.1 - 5.1e-18 65.3 0.0 1.6e-17 63.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF41658.1 - 6e-10 39.0 0.0 1.2e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.7 CCF41658.1 - 3.7e-09 36.3 0.2 1.1e-08 34.7 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Methyltransf_18 PF12847.2 CCF41658.1 - 1.2e-07 32.3 0.0 5.2e-07 30.2 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF41658.1 - 1.2e-07 31.3 0.0 2.8e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF41658.1 - 1.7e-06 28.4 0.0 4.5e-06 27.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF41658.1 - 0.0015 17.7 0.0 0.0031 16.6 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 CCF41658.1 - 0.012 16.0 0.0 0.079 13.3 0.0 2.4 3 0 0 3 3 3 0 Methyltransferase domain ADH_zinc_N_2 PF13602.1 CCF41658.1 - 0.028 15.3 0.0 0.12 13.3 0.0 2.1 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Mg_trans_NIPA PF05653.9 CCF41659.1 - 9.7e-17 60.8 10.2 1.7e-16 60.0 7.1 1.3 1 1 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.15 CCF41659.1 - 1.4e-05 25.1 12.9 0.00017 21.5 0.1 2.6 2 0 0 2 2 2 2 EamA-like transporter family COX4_pro_2 PF07835.7 CCF41659.1 - 0.041 13.8 1.3 1.3 9.0 0.1 2.7 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV Neurensin PF14927.1 CCF41659.1 - 0.14 11.5 4.0 1 8.7 0.1 3.2 4 0 0 4 4 4 0 Neurensin DUF373 PF04123.8 CCF41659.1 - 2.8 6.8 6.2 1.2 8.1 2.5 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF373) Cellulase PF00150.13 CCF41661.1 - 8.4e-49 166.2 0.0 1.1e-48 165.8 0.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) LrgB PF04172.11 CCF41663.1 - 6.2e-28 97.4 6.3 6.2e-27 94.1 4.3 1.9 1 1 0 1 1 1 1 LrgB-like family DUF1614 PF07758.6 CCF41663.1 - 0.85 9.3 6.7 0.15 11.7 0.7 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1614) Fucose_iso_C PF02952.12 CCF41664.1 - 0.042 13.3 0.1 0.054 13.0 0.1 1.1 1 0 0 1 1 1 0 L-fucose isomerase, C-terminal domain NmrA PF05368.8 CCF41665.1 - 4.6e-13 48.9 0.6 5e-13 48.8 0.4 1.0 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.14 CCF41665.1 - 1.2e-06 27.5 0.1 1.4e-06 27.2 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 CCF41665.1 - 1.4e-05 24.7 0.1 1.6e-05 24.4 0.1 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF41665.1 - 1.8e-05 24.8 0.5 2.1e-05 24.6 0.3 1.0 1 0 0 1 1 1 1 NADH(P)-binding KR PF08659.5 CCF41665.1 - 6.3e-05 22.7 0.4 7.6e-05 22.4 0.3 1.0 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 CCF41665.1 - 0.0001 22.2 0.7 0.00011 22.1 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Saccharop_dh PF03435.13 CCF41665.1 - 0.0038 16.2 0.2 0.0042 16.1 0.1 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase F420_oxidored PF03807.12 CCF41665.1 - 0.011 16.0 0.2 0.013 15.9 0.1 1.1 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 CCF41665.1 - 0.044 13.8 0.2 0.047 13.7 0.2 1.1 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF2338 PF10100.4 CCF41665.1 - 0.081 11.2 0.1 0.089 11.1 0.1 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2338) RmlD_sub_bind PF04321.12 CCF41665.1 - 0.099 11.5 0.1 0.1 11.4 0.1 1.1 1 0 0 1 1 1 0 RmlD substrate binding domain Semialdhyde_dh PF01118.19 CCF41665.1 - 0.1 12.8 0.1 0.12 12.7 0.1 1.1 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 CCF41665.1 - 0.11 12.3 0.1 0.12 12.2 0.1 1.1 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DUF3722 PF12519.3 CCF41667.1 - 1e-82 277.3 0.0 1.6e-82 276.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3722) Porin_3 PF01459.17 CCF41667.1 - 1.5e-06 27.7 0.2 0.0017 17.6 0.0 2.6 3 0 0 3 3 3 2 Eukaryotic porin zf-C2H2_4 PF13894.1 CCF41669.1 - 8.3e-05 22.6 16.4 0.13 12.6 0.0 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF41669.1 - 8.5e-05 22.6 19.8 1.6 9.2 0.0 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 CCF41669.1 - 0.00086 19.1 1.3 0.068 13.0 0.7 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger TT_ORF2 PF02957.10 CCF41669.1 - 0.012 16.3 2.3 0.03 15.0 1.6 1.7 1 0 0 1 1 1 0 TT viral ORF2 DUF629 PF04780.7 CCF41669.1 - 0.098 11.1 0.4 0.33 9.4 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF629) PGA2 PF07543.7 CCF41669.1 - 0.41 10.4 3.1 0.8 9.4 2.2 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 SH3_9 PF14604.1 CCF41670.1 - 1.1e-19 69.7 3.8 6.5e-14 51.2 0.2 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.23 CCF41670.1 - 5e-19 67.4 4.7 4.3e-12 45.2 0.4 2.5 2 0 0 2 2 2 2 SH3 domain Cofilin_ADF PF00241.15 CCF41670.1 - 1.4e-10 41.1 0.0 2.3e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_2 PF07653.12 CCF41670.1 - 5.9e-09 35.2 0.1 1.3e-07 30.9 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain DUF543 PF04418.7 CCF41670.1 - 0.35 10.8 2.9 0.92 9.5 2.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF543) NADH_u_ox_C PF12853.2 CCF41672.1 - 5.7e-33 112.5 0.1 6.9e-33 112.2 0.0 1.1 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit ATP-synt_E PF05680.7 CCF41672.1 - 0.31 10.9 1.7 0.6 10.1 0.2 2.1 1 1 0 2 2 2 0 ATP synthase E chain Glyco_hydro_12 PF01670.11 CCF41673.1 - 5.2e-13 49.0 1.7 8.6e-13 48.3 1.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 Mucin PF01456.12 CCF41673.1 - 0.018 14.8 12.3 0.031 14.0 8.5 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein SSP160 PF06933.6 CCF41673.1 - 0.53 8.1 8.7 0.76 7.6 6.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DNA_pol_B PF00136.16 CCF41675.1 - 1.5e-113 380.0 0.7 2.2e-113 379.5 0.5 1.2 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.5 CCF41675.1 - 8.7e-53 178.4 0.5 1.5e-52 177.7 0.3 1.4 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.14 CCF41675.1 - 2.6e-38 131.6 0.0 9.1e-38 129.9 0.0 1.8 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DUF4083 PF13314.1 CCF41677.1 - 0.094 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) Bestrophin PF01062.16 CCF41677.1 - 0.12 11.3 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel Fungal_trans PF04082.13 CCF41679.1 - 1.6e-13 50.1 0.0 3e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41679.1 - 7e-06 25.8 7.7 1.3e-05 24.9 5.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.17 CCF41680.1 - 0.12 10.8 0.0 0.13 10.7 0.0 1.0 1 0 0 1 1 1 0 Cytochrome P450 Proteasom_Rpn13 PF04683.8 CCF41683.1 - 1.4e-25 89.2 0.0 2.2e-25 88.5 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor L27_2 PF09045.5 CCF41683.1 - 0.011 15.2 0.1 0.023 14.2 0.1 1.5 1 0 0 1 1 1 0 L27_2 EF1_GNE PF00736.14 CCF41684.1 - 3.3e-29 100.4 1.1 5.7e-29 99.6 0.8 1.3 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.4 CCF41684.1 - 2.4e-14 53.1 9.7 2.4e-14 53.1 6.7 2.3 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.1 CCF41684.1 - 4.1e-05 23.9 0.0 0.0003 21.2 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 CCF41684.1 - 0.00073 19.4 0.3 0.0032 17.4 0.0 2.2 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Cwf_Cwc_15 PF04889.7 CCF41684.1 - 0.014 15.1 1.0 0.018 14.7 0.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein GST_C_2 PF13410.1 CCF41684.1 - 0.13 12.1 0.3 2.7 7.9 0.2 2.4 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DNA_pol3_a_NII PF11490.3 CCF41684.1 - 2.2 7.8 8.4 1.5 8.4 0.1 2.2 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II Sld5 PF05916.6 CCF41685.1 - 3.8e-10 40.0 0.0 5.7e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein Sulfate_transp PF00916.15 CCF41686.1 - 1.8e-29 102.6 0.3 4e-29 101.4 0.1 1.7 1 1 0 1 1 1 1 Sulfate transporter family cNMP_binding PF00027.24 CCF41686.1 - 5.7e-17 61.3 0.0 1.2e-16 60.2 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.16 CCF41686.1 - 1.1e-10 41.0 0.0 1.9e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 STAS domain adh_short PF00106.20 CCF41687.1 - 1.4e-34 119.3 2.0 2e-34 118.9 1.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF41687.1 - 1.2e-17 64.4 0.0 1.6e-17 64.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF41687.1 - 1.2e-15 57.6 0.8 1.7e-15 57.1 0.6 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF41687.1 - 1.8e-06 27.6 0.1 3.8e-06 26.5 0.1 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.13 CCF41687.1 - 0.0007 19.3 0.1 0.001 18.7 0.1 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.12 CCF41687.1 - 0.0011 17.9 0.1 0.0016 17.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.8 CCF41687.1 - 0.0029 16.9 0.2 0.004 16.4 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF41687.1 - 0.0034 17.4 0.6 0.0099 15.8 0.5 1.7 2 0 0 2 2 2 1 NADH(P)-binding 3Beta_HSD PF01073.14 CCF41687.1 - 0.0037 16.0 0.1 0.0047 15.6 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Urocanase PF01175.13 CCF41687.1 - 0.0088 14.1 0.1 0.01 13.8 0.1 1.1 1 0 0 1 1 1 1 Urocanase Eno-Rase_NADH_b PF12242.3 CCF41687.1 - 0.01 15.5 2.4 0.014 15.1 0.5 2.1 2 1 1 3 3 3 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Polysacc_synt_2 PF02719.10 CCF41687.1 - 0.016 14.1 0.1 0.033 13.0 0.0 1.5 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Methyltransf_25 PF13649.1 CCF41687.1 - 0.018 15.3 0.0 0.042 14.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain TrkA_N PF02254.13 CCF41687.1 - 0.028 14.4 0.1 0.047 13.7 0.1 1.3 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_4 PF07993.7 CCF41687.1 - 0.028 13.3 0.5 0.056 12.3 0.3 1.5 1 1 0 1 1 1 0 Male sterility protein THF_DHG_CYH_C PF02882.14 CCF41687.1 - 0.031 13.3 0.0 0.054 12.5 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_7 PF13241.1 CCF41687.1 - 0.044 14.0 0.1 0.071 13.3 0.1 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding F420_oxidored PF03807.12 CCF41687.1 - 0.046 14.1 0.1 0.22 11.9 0.1 1.9 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.16 CCF41687.1 - 0.052 13.3 0.3 0.094 12.5 0.2 1.3 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 CCF41687.1 - 0.058 12.5 0.2 0.18 10.9 0.1 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 CCF41687.1 - 0.1 11.9 0.1 0.18 11.1 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Hydrophobin_2 PF06766.6 CCF41688.1 - 1e-14 53.9 8.0 1.6e-14 53.3 5.5 1.4 1 0 0 1 1 1 1 Fungal hydrophobin adh_short PF00106.20 CCF41689.1 - 9.1e-23 80.9 0.1 1.3e-22 80.5 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF41689.1 - 3.1e-17 62.8 0.0 4.4e-17 62.3 0.0 1.1 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF41689.1 - 4.5e-12 46.2 0.1 6e-12 45.8 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 CCF41689.1 - 4.7e-08 32.7 0.0 8.2e-08 31.9 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PAC2 PF09754.4 CCF41689.1 - 0.034 14.0 0.0 1.2 8.9 0.0 2.4 2 1 0 2 2 2 0 PAC2 family Polysacc_synt_2 PF02719.10 CCF41689.1 - 0.069 12.0 0.0 0.085 11.7 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein MMS1_N PF10433.4 CCF41690.1 - 1.4e-84 284.0 0.0 2.3e-84 283.3 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.10 CCF41690.1 - 9.5e-28 97.2 0.0 1.3e-25 90.2 0.0 2.9 2 1 1 3 3 3 2 CPSF A subunit region Proteasome_A_N PF10584.4 CCF41690.1 - 0.11 11.9 0.1 2.7 7.3 0.0 2.7 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature UPF0233 PF06781.7 CCF41692.1 - 0.00018 21.0 0.1 0.45 10.1 0.0 3.1 3 0 0 3 3 3 2 Uncharacterised protein family (UPF0233) DUF1510 PF07423.6 CCF41692.1 - 0.025 13.9 3.9 2.1 7.6 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1510) 7tm_1 PF00001.16 CCF41692.1 - 0.032 13.3 0.3 0.12 11.5 0.0 2.0 2 1 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) O-antigen_lig PF13425.1 CCF41692.1 - 0.074 13.0 7.4 2 8.4 0.1 3.4 2 2 1 3 3 3 0 O-antigen ligase like membrane protein DUF3357 PF11837.3 CCF41692.1 - 0.18 11.6 0.7 3.2 7.6 0.0 3.2 2 2 3 5 5 5 0 Domain of unknown function (DUF3357) PGAP1 PF07819.8 CCF41693.1 - 7.1e-06 25.7 0.0 1e-05 25.2 0.0 1.4 1 1 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.2 CCF41693.1 - 0.00011 22.2 0.0 0.00013 21.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF41693.1 - 0.00011 21.9 0.0 0.00015 21.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.9 CCF41693.1 - 0.0003 20.1 0.0 0.0004 19.7 0.0 1.1 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF2305 PF10230.4 CCF41693.1 - 0.0055 16.1 0.0 0.0061 16.0 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) DUF915 PF06028.6 CCF41693.1 - 0.022 13.8 0.0 3.3 6.7 0.0 2.4 2 1 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) DUF900 PF05990.7 CCF41693.1 - 0.047 13.0 0.0 0.25 10.6 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) SAM_2 PF07647.12 CCF41694.1 - 1.3e-16 60.1 0.0 2.5e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 CCF41694.1 - 1.9e-15 56.7 0.0 3.4e-15 55.9 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.18 CCF41694.1 - 1.1e-13 51.4 0.0 2.6e-13 50.2 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain CCDC66 PF15236.1 CCF41694.1 - 2 8.0 5.1 16 5.0 0.5 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 66 Myb_DNA-bind_6 PF13921.1 CCF41695.1 - 4.8e-06 26.5 0.1 1.2e-05 25.2 0.0 1.7 1 1 1 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 CCF41695.1 - 0.0015 18.5 0.0 0.0066 16.4 0.0 2.2 1 1 0 1 1 1 1 Myb-like DNA-binding domain Rap1_C PF11626.3 CCF41695.1 - 0.0077 16.0 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain PAT1 PF09770.4 CCF41695.1 - 0.2 9.8 9.0 0.22 9.7 6.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3824 PF12868.2 CCF41695.1 - 1.8 9.4 17.7 0.12 13.3 8.8 1.6 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) DUF2236 PF09995.4 CCF41696.1 - 3.9e-05 23.0 0.2 7.7e-05 22.0 0.2 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) Kelch_3 PF13415.1 CCF41697.1 - 6.3e-21 73.9 8.6 1.1e-10 41.3 0.0 6.5 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.1 CCF41697.1 - 5e-20 71.0 0.3 1.1e-08 34.7 0.0 5.1 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_6 PF13964.1 CCF41697.1 - 4.6e-12 45.5 4.0 0.0023 18.0 0.6 4.7 3 1 1 4 4 4 3 Kelch motif Kelch_5 PF13854.1 CCF41697.1 - 6.6e-12 45.1 6.4 1.9e-06 27.6 0.1 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.20 CCF41697.1 - 2.7e-11 42.8 0.1 0.0018 17.7 0.0 4.1 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.10 CCF41697.1 - 7.1e-08 31.9 0.4 0.00021 20.9 0.0 4.7 5 1 0 5 5 5 1 Kelch motif BTB PF00651.26 CCF41697.1 - 0.019 14.9 0.0 0.13 12.3 0.0 2.1 2 0 0 2 2 2 0 BTB/POZ domain ADH_N PF08240.7 CCF41699.1 - 6.2e-26 90.2 7.1 7.5e-26 90.0 4.9 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DZR PF12773.2 CCF41699.1 - 0.056 13.2 3.0 0.15 11.8 2.1 1.7 1 1 0 1 1 1 0 Double zinc ribbon Fer4_8 PF13183.1 CCF41699.1 - 1.2 9.1 6.1 1.2 9.2 1.9 1.8 1 1 1 2 2 2 0 4Fe-4S dicluster domain Totivirus_coat PF05518.6 CCF41702.1 - 4.1 5.0 6.3 5.2 4.7 4.4 1.3 1 0 0 1 1 1 0 Totivirus coat protein AMP-binding PF00501.23 CCF41703.1 - 5.6e-86 288.5 0.0 6.6e-86 288.3 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF41703.1 - 1.2e-16 61.4 0.0 2.8e-16 60.2 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.8 CCF41703.1 - 0.00069 18.2 0.0 0.014 13.9 0.0 2.1 2 0 0 2 2 2 1 GH3 auxin-responsive promoter Acetyltransf_7 PF13508.1 CCF41705.1 - 7.8e-09 35.5 0.0 1.4e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CCF41705.1 - 1.3e-06 28.3 0.0 2.3e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 CCF41705.1 - 4.2e-05 23.6 0.0 9.4e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 CCF41705.1 - 0.0024 17.7 0.0 0.004 16.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF41705.1 - 0.0026 17.4 0.0 0.0046 16.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.1 CCF41705.1 - 0.0065 16.3 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase RR_TM4-6 PF06459.7 CCF41705.1 - 0.058 13.2 0.3 0.073 12.9 0.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Daxx PF03344.10 CCF41705.1 - 0.26 9.7 5.7 0.35 9.3 3.9 1.0 1 0 0 1 1 1 0 Daxx Family Clat_adaptor_s PF01217.15 CCF41707.1 - 3.2e-56 188.9 1.5 3.6e-56 188.8 1.1 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain CRA PF06589.6 CCF41709.1 - 0.15 11.3 0.5 0.24 10.6 0.3 1.2 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) Thionin PF00321.12 CCF41711.1 - 0.14 12.4 0.2 0.14 12.4 0.1 2.6 3 0 0 3 3 3 0 Plant thionin p450 PF00067.17 CCF41713.1 - 9.8e-09 34.2 0.0 1.2e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ADK PF00406.17 CCF41714.1 - 1.4e-26 93.2 0.1 1.9e-26 92.7 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase Laminin_II PF06009.7 CCF41714.1 - 0.052 13.3 0.1 0.078 12.7 0.0 1.4 1 0 0 1 1 1 0 Laminin Domain II BLOC1_2 PF10046.4 CCF41714.1 - 0.056 13.5 0.4 0.1 12.7 0.3 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MitMem_reg PF13012.1 CCF41715.1 - 1.7e-38 131.2 0.0 3.4e-38 130.2 0.0 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.16 CCF41715.1 - 1.1e-27 96.0 0.3 2.8e-27 94.7 0.0 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF4407 PF14362.1 CCF41715.1 - 1.2 8.0 5.2 1.6 7.6 3.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LNS2 PF08235.8 CCF41716.1 - 1.3e-70 236.0 0.0 2.3e-70 235.1 0.0 1.4 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Acid_phosphat_B PF03767.9 CCF41716.1 - 0.00092 18.6 0.0 0.081 12.2 0.0 2.3 2 0 0 2 2 2 2 HAD superfamily, subfamily IIIB (Acid phosphatase) Nucleoplasmin PF03066.10 CCF41716.1 - 5.8 6.4 17.4 5.5 6.4 1.3 2.3 2 0 0 2 2 2 0 Nucleoplasmin TFIID-31kDa PF02291.10 CCF41717.1 - 1.6e-27 95.8 0.0 1.9e-26 92.3 0.0 2.1 1 1 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Pex14_N PF04695.8 CCF41717.1 - 0.15 12.1 17.0 0.29 11.1 11.8 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.8 CCF41717.1 - 0.52 10.1 22.7 0.031 14.1 11.1 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.9 CCF41717.1 - 1.7 8.3 16.6 2.2 7.9 11.5 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Lin-8 PF03353.10 CCF41717.1 - 5.5 6.1 9.0 8.8 5.5 6.3 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist ketoacyl-synt PF00109.21 CCF41720.1 - 4.3e-68 229.5 0.0 5.2e-68 229.2 0.0 1.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 CCF41720.1 - 1.8e-13 50.3 0.0 3.3e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 CCF41720.1 - 0.011 14.8 0.1 0.015 14.3 0.0 1.1 1 0 0 1 1 1 0 Thiolase, N-terminal domain ACP_syn_III PF08545.5 CCF41720.1 - 0.073 12.7 0.2 0.14 11.8 0.2 1.4 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Peptidase_S8 PF00082.17 CCF41721.1 - 3.5e-18 65.7 0.3 4.9e-18 65.2 0.2 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 CCF41721.1 - 0.16 12.5 0.0 0.38 11.3 0.0 1.6 1 0 0 1 1 1 0 Peptidase inhibitor I9 Rotamase PF00639.16 CCF41722.1 - 3.9e-19 69.1 0.1 6.7e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 CCF41722.1 - 1e-18 67.6 0.1 1.4e-18 67.2 0.1 1.4 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 CCF41722.1 - 6.8e-06 26.7 0.4 1.1e-05 26.0 0.1 1.4 1 1 1 2 2 2 1 PPIC-type PPIASE domain Ribosomal_L7Ae PF01248.21 CCF41723.1 - 1.3e-28 98.3 1.0 1.6e-28 98.0 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PucR PF07905.6 CCF41723.1 - 0.09 12.3 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Purine catabolism regulatory protein-like family Ribosomal_S8 PF00410.14 CCF41724.1 - 8.1e-26 90.3 0.0 1.1e-25 89.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 Herpes_pp38 PF04846.8 CCF41725.1 - 0.028 13.7 0.8 5.8 6.3 0.2 2.9 2 0 0 2 2 2 0 Herpesvirus pp38 phosphoprotein SBP_bac_6 PF13343.1 CCF41727.1 - 0.0028 17.0 0.2 0.0043 16.4 0.2 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein MFS_1 PF07690.11 CCF41729.1 - 4.4e-13 48.6 19.0 5.6e-13 48.3 13.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Git3 PF11710.3 CCF41731.1 - 6.6e-21 74.7 7.2 1.4e-20 73.7 5.0 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.16 CCF41731.1 - 2e-09 36.9 5.4 2.7e-09 36.5 3.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3_C PF11970.3 CCF41731.1 - 0.00095 18.8 0.4 0.0031 17.2 0.3 1.8 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Dicty_CAR PF05462.6 CCF41731.1 - 0.16 10.7 12.2 0.016 14.1 5.3 1.5 2 0 0 2 2 2 0 Slime mold cyclic AMP receptor FixP_N PF14715.1 CCF41731.1 - 5.3 6.5 10.5 13 5.2 2.0 2.6 2 0 0 2 2 2 0 N-terminal domain of cytochrome oxidase-cbb3, FixP SdpI PF13630.1 CCF41732.1 - 0.084 12.5 7.8 0.14 11.8 5.1 1.6 1 1 0 1 1 1 0 SdpI/YhfL protein family GMC_oxred_C PF05199.8 CCF41733.1 - 1.1e-21 77.6 0.0 1.3e-21 77.4 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase Zn_Tnp_IS1595 PF12760.2 CCF41733.1 - 0.12 12.1 0.2 0.2 11.5 0.1 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Acyl-CoA_dh_1 PF00441.19 CCF41734.1 - 1.3e-27 96.7 0.2 2.2e-27 96.0 0.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 CCF41734.1 - 3.9e-15 55.0 0.0 8.2e-15 54.0 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 CCF41734.1 - 1.7e-13 50.9 0.3 2.8e-13 50.2 0.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 CCF41734.1 - 1.2e-12 48.4 0.0 2.1e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Skp1 PF01466.14 CCF41735.1 - 0.18 11.8 2.3 0.37 10.8 1.6 1.6 1 0 0 1 1 1 0 Skp1 family, dimerisation domain NAD_binding_6 PF08030.7 CCF41735.1 - 2.3 8.0 6.7 0.5 10.2 1.2 1.9 2 0 0 2 2 2 0 Ferric reductase NAD binding domain CENP-H PF05837.7 CCF41735.1 - 9.7 6.4 11.6 0.46 10.6 3.7 2.1 2 1 0 2 2 2 0 Centromere protein H (CENP-H) Abhydrolase_6 PF12697.2 CCF41736.1 - 4.3e-10 39.8 0.0 7e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF41736.1 - 4.4e-06 26.4 0.0 4.2e-05 23.2 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF41736.1 - 4.5e-05 23.2 0.0 9.2e-05 22.2 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Cutinase PF01083.17 CCF41736.1 - 0.015 15.0 0.0 0.03 14.0 0.0 1.5 1 0 0 1 1 1 0 Cutinase Peptidase_S15 PF02129.13 CCF41736.1 - 0.029 13.7 0.0 0.042 13.2 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Cohesin_load PF10345.4 CCF41737.1 - 7.3e-131 437.3 0.0 1e-130 436.8 0.0 1.1 1 0 0 1 1 1 1 Cohesin loading factor Pet127 PF08634.5 CCF41737.1 - 1.1e-14 54.2 0.0 2.7e-14 52.9 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial protein Pet127 DUF1985 PF09331.6 CCF41737.1 - 0.046 13.5 0.1 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1985) Pil1 PF13805.1 CCF41739.1 - 3.6e-108 360.8 5.7 5.3e-108 360.2 3.6 1.4 2 0 0 2 2 2 1 Eisosome component PIL1 Ribophorin_I PF04597.9 CCF41740.1 - 5.6e-150 499.6 1.4 6.4e-150 499.4 1.0 1.0 1 0 0 1 1 1 1 Ribophorin I Hexokinase_2 PF03727.11 CCF41741.1 - 2.8e-90 301.7 0.0 4.2e-90 301.2 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 CCF41741.1 - 6.3e-78 260.8 0.0 1.5e-76 256.2 0.0 2.0 2 0 0 2 2 2 1 Hexokinase RVT_1 PF00078.22 CCF41741.1 - 0.05 12.9 0.0 0.071 12.4 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) MiAMP1 PF09117.5 CCF41741.1 - 0.076 13.4 0.4 0.2 12.0 0.3 1.6 1 0 0 1 1 1 0 MiAMP1 Ank_2 PF12796.2 CCF41742.1 - 3.5e-07 30.4 0.2 1.9e-05 24.9 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF41742.1 - 0.016 15.6 0.0 2.5 8.7 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeats (many copies) VTC PF09359.5 CCF41743.1 - 6.2e-101 337.1 0.0 1e-100 336.4 0.0 1.3 1 0 0 1 1 1 1 VTC domain SPX PF03105.14 CCF41743.1 - 1.5e-26 93.8 2.6 3.3e-23 82.8 1.0 3.0 2 1 0 2 2 2 1 SPX domain DUF202 PF02656.10 CCF41743.1 - 1.5e-13 50.7 2.1 3e-13 49.7 1.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF202) PMP22_Claudin PF00822.15 CCF41743.1 - 0.17 11.5 1.0 0.29 10.7 0.7 1.3 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family Cys_Met_Meta_PP PF01053.15 CCF41744.1 - 2.2e-26 92.0 0.0 1.2e-25 89.6 0.0 1.8 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme LysM PF01476.15 CCF41745.1 - 5.9e-18 64.4 0.0 2.7e-06 27.1 0.0 3.3 3 0 0 3 3 3 3 LysM domain NLPC_P60 PF00877.14 CCF41745.1 - 0.0035 17.1 0.8 0.17 11.7 0.0 2.9 3 0 0 3 3 3 1 NlpC/P60 family LRV_FeS PF05484.6 CCF41745.1 - 0.041 13.4 0.0 4.5 6.9 0.0 2.9 3 0 0 3 3 3 0 LRV protein FeS4 cluster LysM PF01476.15 CCF41746.1 - 1.4e-07 31.2 0.0 3.1e-06 26.9 0.0 2.3 2 0 0 2 2 2 1 LysM domain Glyco_hydro_18 PF00704.23 CCF41747.1 - 2.5e-19 69.9 0.0 3.1e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 NPV_P10 PF05531.7 CCF41748.1 - 0.033 14.4 6.5 0.22 11.7 0.1 3.0 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Mito_fiss_reg PF05308.6 CCF41748.1 - 0.24 10.7 1.4 0.8 9.0 0.7 1.7 1 1 1 2 2 2 0 Mitochondrial fission regulator Lipase_GDSL_2 PF13472.1 CCF41748.1 - 3.2 7.8 7.7 6.4 6.8 2.4 2.3 1 1 1 2 2 2 0 GDSL-like Lipase/Acylhydrolase family Laminin_I PF06008.9 CCF41749.1 - 0.0014 17.9 6.7 0.0014 17.9 4.7 3.7 1 1 3 4 4 4 1 Laminin Domain I CENP-F_leu_zip PF10473.4 CCF41749.1 - 0.0021 17.9 41.7 0.072 12.9 0.1 4.3 2 2 2 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.9 CCF41749.1 - 0.0037 16.8 38.2 0.051 13.1 3.6 3.9 1 1 2 3 3 3 3 IncA protein Reo_sigmaC PF04582.7 CCF41749.1 - 0.17 11.0 14.7 0.19 10.8 1.8 3.0 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Striatin PF08232.7 CCF41749.1 - 0.29 11.4 38.9 0.047 13.9 7.4 3.9 1 1 1 3 3 3 0 Striatin family BLOC1_2 PF10046.4 CCF41749.1 - 0.42 10.7 29.9 0.096 12.8 4.2 5.4 2 2 3 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF972 PF06156.8 CCF41749.1 - 0.69 10.2 35.0 2.1 8.7 4.0 5.2 1 1 3 4 4 4 0 Protein of unknown function (DUF972) CALCOCO1 PF07888.6 CCF41749.1 - 1.5 6.9 40.2 1.6 6.9 17.2 2.7 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like ADIP PF11559.3 CCF41749.1 - 1.6 8.6 48.3 1.7 8.4 2.8 5.3 1 1 5 6 6 6 0 Afadin- and alpha -actinin-Binding TPR_MLP1_2 PF07926.7 CCF41749.1 - 3.1 7.5 50.3 27 4.4 11.9 4.7 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein GAS PF13851.1 CCF41749.1 - 3.1 6.9 42.2 0.062 12.4 5.5 3.2 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Filament PF00038.16 CCF41749.1 - 5.1 6.4 46.2 1.2 8.4 3.5 3.0 1 1 0 2 2 2 0 Intermediate filament protein Shugoshin_N PF07558.6 CCF41749.1 - 5.7 6.7 18.3 0.11 12.1 2.8 3.8 5 0 0 5 5 5 0 Shugoshin N-terminal coiled-coil region Peptidase_S41 PF03572.13 CCF41750.1 - 7.9e-10 38.3 0.0 1.5e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S41 DUF3446 PF11928.3 CCF41750.1 - 0.17 12.1 9.1 0.18 12.0 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) Glyco_hydro_47 PF01532.15 CCF41752.1 - 1.7e-32 112.7 0.1 1.8e-32 112.5 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 ADH_N PF08240.7 CCF41755.1 - 1.5e-29 101.9 4.6 2.7e-29 101.1 2.2 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF41755.1 - 2.5e-16 59.3 0.0 3.8e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF41755.1 - 1.6e-05 25.8 0.0 2.9e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_18 PF12847.2 CCF41755.1 - 0.0038 17.7 0.0 0.0078 16.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FAD_binding_3 PF01494.14 CCF41755.1 - 0.021 13.9 0.1 0.032 13.2 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Gp_dh_N PF00044.19 CCF41755.1 - 0.029 14.3 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain fn3 PF00041.16 CCF41755.1 - 0.067 13.3 0.0 11 6.2 0.0 2.3 2 0 0 2 2 2 0 Fibronectin type III domain DUF3712 PF12505.3 CCF41756.1 - 6.6e-11 42.3 0.0 1.4e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3712) HECT PF00632.20 CCF41757.1 - 3.4e-77 259.7 0.0 4.8e-77 259.2 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) TrbE PF11100.3 CCF41757.1 - 0.079 12.8 0.1 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Conjugal transfer protein TrbE C1_1 PF00130.17 CCF41757.1 - 0.094 12.4 0.4 0.18 11.5 0.3 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Mito_carr PF00153.22 CCF41758.1 - 5.6e-19 67.6 0.3 9e-16 57.3 0.0 2.3 2 1 0 2 2 2 2 Mitochondrial carrier protein DUF3021 PF11457.3 CCF41759.1 - 0.0063 16.3 4.8 0.011 15.5 3.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3021) NfeD PF01957.13 CCF41759.1 - 0.024 14.7 1.7 0.047 13.8 1.2 1.4 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding FtsX PF02687.16 CCF41759.1 - 0.057 13.1 4.8 0.11 12.2 3.3 1.5 1 0 0 1 1 1 0 FtsX-like permease family SURF4 PF02077.10 CCF41759.1 - 0.06 12.7 1.3 0.086 12.1 0.9 1.1 1 0 0 1 1 1 0 SURF4 family SUR7 PF06687.7 CCF41759.1 - 0.061 12.8 5.9 0.093 12.2 4.1 1.2 1 0 0 1 1 1 0 SUR7/PalI family HOK_GEF PF01848.11 CCF41761.1 - 0.092 12.0 0.7 0.21 10.9 0.5 1.5 1 0 0 1 1 1 0 Hok/gef family UQ_con PF00179.21 CCF41762.1 - 4.9e-09 35.7 0.0 1.1e-08 34.6 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme F-box PF00646.28 CCF41762.1 - 0.00014 21.3 0.1 0.0004 19.9 0.1 1.8 1 0 0 1 1 1 1 F-box domain TRCF PF03461.10 CCF41762.1 - 0.032 14.1 0.0 0.078 12.9 0.0 1.6 1 0 0 1 1 1 0 TRCF domain DIT1_PvcA PF05141.7 CCF41764.1 - 2.2e-76 256.8 0.0 2.8e-76 256.5 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein DIT1_PvcA PF05141.7 CCF41765.1 - 1.9e-14 53.6 0.0 2.3e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein Fungal_trans PF04082.13 CCF41766.1 - 5.2e-27 94.3 0.0 9.2e-27 93.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41766.1 - 1.5e-09 37.5 10.9 2.4e-09 36.9 7.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain IF-2B PF01008.12 CCF41767.1 - 0.045 12.7 0.1 0.047 12.6 0.1 1.0 1 0 0 1 1 1 0 Initiation factor 2 subunit family WD40 PF00400.27 CCF41768.1 - 6.9e-42 139.8 18.8 4.2e-07 29.5 0.1 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat HIRA_B PF09453.5 CCF41768.1 - 2.2e-08 33.4 0.4 5.2e-08 32.2 0.3 1.7 1 0 0 1 1 1 1 HIRA B motif PD40 PF07676.7 CCF41768.1 - 0.0015 18.1 0.2 4 7.2 0.0 4.1 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat IKI3 PF04762.7 CCF41768.1 - 0.0061 14.4 0.2 0.032 12.0 0.0 2.1 2 1 1 3 3 3 1 IKI3 family YmzC PF14157.1 CCF41768.1 - 0.095 12.5 0.0 0.26 11.1 0.0 1.8 1 0 0 1 1 1 0 YmzC-like protein PepX_C PF08530.5 CCF41770.1 - 1.6e-39 136.0 3.1 2.5e-39 135.4 2.2 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Peptidase_S15 PF02129.13 CCF41770.1 - 1.5e-37 129.5 0.1 2.3e-37 128.9 0.1 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.2 CCF41770.1 - 1.8e-06 28.0 0.1 3.4e-06 27.1 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF41770.1 - 7.5e-05 22.5 0.0 0.00016 21.4 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CCF41770.1 - 0.0052 16.6 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase IN_DBD_C PF00552.16 CCF41770.1 - 0.028 13.8 0.0 0.088 12.2 0.0 1.8 1 0 0 1 1 1 0 Integrase DNA binding domain Sugar_tr PF00083.19 CCF41771.1 - 1.4e-43 149.1 20.2 4.7e-43 147.4 14.0 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF41771.1 - 2.6e-17 62.5 26.8 5.3e-17 61.5 18.1 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Peptidase_M6 PF05547.6 CCF41773.1 - 7.3e-08 30.9 0.1 0.0026 15.8 0.5 2.1 2 0 0 2 2 2 2 Immune inhibitor A peptidase M6 DIOX_N PF14226.1 CCF41774.1 - 5.8e-30 104.2 0.0 9.1e-30 103.5 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 CCF41774.1 - 8.3e-16 58.0 0.0 2.9e-15 56.3 0.0 1.9 3 0 0 3 3 3 1 2OG-Fe(II) oxygenase superfamily Peroxidase_2 PF01328.12 CCF41775.1 - 9.2e-44 149.3 0.0 1.1e-43 149.0 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 MFS_1 PF07690.11 CCF41776.1 - 2.5e-21 75.7 20.1 3.3e-21 75.3 13.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4131 PF13567.1 CCF41776.1 - 0.26 10.6 0.0 0.26 10.6 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Dynein_heavy PF03028.10 CCF41779.1 - 4.7e-23 81.1 0.0 5.2e-23 80.9 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor MARVEL PF01284.18 CCF41783.1 - 1 9.1 4.9 7.6 6.3 3.4 2.0 1 1 0 1 1 1 0 Membrane-associating domain Fungal_trans PF04082.13 CCF41784.1 - 3.3e-22 78.6 0.7 4.9e-22 78.0 0.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41784.1 - 2e-07 30.7 9.3 3.2e-07 30.1 6.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4110 PF13422.1 CCF41785.1 - 1.2e-28 98.8 1.3 1.2e-28 98.8 0.9 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4110) YL1 PF05764.8 CCF41785.1 - 0.00079 19.1 13.3 0.001 18.7 9.2 1.2 1 0 0 1 1 1 1 YL1 nuclear protein CDC45 PF02724.9 CCF41785.1 - 0.0028 15.7 9.7 0.0035 15.4 6.7 1.3 1 0 0 1 1 1 1 CDC45-like protein Kelch_5 PF13854.1 CCF41785.1 - 0.0055 16.6 0.0 0.0099 15.8 0.0 1.4 1 0 0 1 1 1 1 Kelch motif ArsA_ATPase PF02374.10 CCF41785.1 - 0.0072 15.3 0.1 0.011 14.7 0.1 1.2 1 0 0 1 1 1 1 Anion-transporting ATPase Nop14 PF04147.7 CCF41785.1 - 0.02 12.8 18.4 0.023 12.6 12.8 1.1 1 0 0 1 1 1 0 Nop14-like family Daxx PF03344.10 CCF41785.1 - 0.045 12.2 19.9 0.051 12.0 13.8 1.1 1 0 0 1 1 1 0 Daxx Family BUD22 PF09073.5 CCF41785.1 - 0.71 8.8 19.1 1.1 8.1 13.2 1.3 1 0 0 1 1 1 0 BUD22 Sporozoite_P67 PF05642.6 CCF41785.1 - 2.1 6.1 14.8 2.8 5.6 10.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SGT1 PF07093.6 CCF41785.1 - 2.2 6.5 18.6 2.8 6.1 12.9 1.1 1 0 0 1 1 1 0 SGT1 protein DUF2722 PF10846.3 CCF41785.1 - 4 6.3 8.9 5.7 5.8 6.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) WLM PF08325.5 CCF41786.1 - 3.3e-49 167.3 0.4 1.9e-48 164.8 0.0 1.9 1 1 0 2 2 2 1 WLM domain DUF45 PF01863.12 CCF41786.1 - 6e-08 32.7 0.1 6e-08 32.7 0.0 2.2 3 1 1 4 4 4 1 Protein of unknown function DUF45 CHGN PF05679.11 CCF41786.1 - 0.026 13.2 0.0 0.049 12.3 0.0 1.4 1 0 0 1 1 1 0 Chondroitin N-acetylgalactosaminyltransferase DUF2036 PF09724.4 CCF41787.1 - 9e-06 25.0 0.0 9.5e-06 24.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2036) IBR PF01485.16 CCF41788.1 - 2.5e-06 27.2 24.4 0.00021 21.0 2.3 2.9 3 0 0 3 3 3 2 IBR domain Rad4 PF03835.10 CCF41789.1 - 3.3e-30 104.4 0.0 1.5e-29 102.2 0.0 2.1 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.4 CCF41789.1 - 2.1e-26 91.3 0.3 4e-26 90.5 0.2 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.4 CCF41789.1 - 2.9e-18 65.1 0.2 7.3e-18 63.8 0.2 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 CCF41789.1 - 7.8e-17 61.3 0.3 7.8e-17 61.3 0.2 4.4 3 0 0 3 3 3 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.14 CCF41789.1 - 0.0018 18.4 0.0 0.0073 16.5 0.0 2.1 1 1 0 1 1 1 1 Transglutaminase-like superfamily zf-AN1 PF01428.11 CCF41790.1 - 2e-24 85.1 19.6 2.5e-12 46.4 5.3 2.2 2 0 0 2 2 2 2 AN1-like Zinc finger Transp_Tc5_C PF04236.10 CCF41790.1 - 0.022 14.9 12.7 0.44 10.8 3.7 2.4 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain IBR PF01485.16 CCF41790.1 - 0.061 13.2 18.9 0.033 14.0 2.0 2.5 2 1 0 2 2 2 0 IBR domain DRP PF06044.7 CCF41790.1 - 0.52 9.2 2.4 6.8 5.5 0.3 2.4 3 0 0 3 3 3 0 Dam-replacing family MTP18 PF10558.4 CCF41791.1 - 5e-58 195.2 0.0 5.9e-58 194.9 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) DHC_N1 PF08385.7 CCF41792.1 - 6e-169 563.1 9.3 6e-169 563.1 6.4 1.6 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 1 MIP PF00230.15 CCF41794.1 - 6.5e-50 169.7 19.2 8.2e-50 169.3 13.3 1.1 1 0 0 1 1 1 1 Major intrinsic protein bZIP_Maf PF03131.12 CCF41795.1 - 7.6e-08 32.5 13.8 2.2e-07 31.0 9.5 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.16 CCF41795.1 - 9.3e-08 31.9 14.9 9.3e-08 31.9 10.3 2.3 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.10 CCF41795.1 - 0.0099 15.6 23.3 0.053 13.3 13.2 3.2 2 1 0 2 2 2 1 Basic region leucine zipper Sec5 PF15469.1 CCF41795.1 - 0.037 13.7 5.8 0.072 12.8 4.0 1.4 1 0 0 1 1 1 0 Exocyst complex component Sec5 Endotoxin_N PF03945.9 CCF41795.1 - 0.12 11.7 5.1 0.23 10.7 3.5 1.4 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain DUF342 PF03961.8 CCF41795.1 - 1.5 7.1 11.1 2.2 6.5 7.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) V_ATPase_I PF01496.14 CCF41795.1 - 3.3 5.4 8.9 4.7 4.9 6.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family IncA PF04156.9 CCF41795.1 - 7 6.1 15.6 17 4.9 10.8 1.6 1 0 0 1 1 1 0 IncA protein Glycos_transf_1 PF00534.15 CCF41796.1 - 4.8e-35 120.5 0.0 7.8e-35 119.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 CCF41796.1 - 2.2e-16 60.2 0.0 3.9e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 CCF41796.1 - 2.1e-15 57.2 1.3 2.1e-15 57.2 0.9 1.8 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.1 CCF41796.1 - 2.8e-11 43.5 0.0 6e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 CCF41796.1 - 0.0002 21.1 2.6 0.0037 17.0 0.8 3.1 2 1 0 2 2 2 1 Glycosyltransferase Family 4 DUF2109 PF09882.4 CCF41796.1 - 0.13 12.2 0.1 0.27 11.2 0.1 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2109) Cutinase PF01083.17 CCF41797.1 - 9.9e-29 100.3 5.4 1.4e-28 99.8 3.8 1.2 1 0 0 1 1 1 1 Cutinase Abhydrolase_1 PF00561.15 CCF41797.1 - 0.00084 18.9 0.3 0.0028 17.2 0.0 1.8 2 1 0 2 2 2 1 alpha/beta hydrolase fold PE-PPE PF08237.6 CCF41797.1 - 0.0021 17.5 0.1 0.0038 16.6 0.1 1.6 1 1 0 1 1 1 1 PE-PPE domain Abhydrolase_5 PF12695.2 CCF41797.1 - 0.05 13.3 2.0 0.077 12.7 1.4 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family Lipase_3 PF01764.20 CCF41797.1 - 0.066 12.8 0.1 0.091 12.3 0.1 1.2 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_2 PF02230.11 CCF41797.1 - 0.077 12.4 0.2 0.16 11.3 0.1 1.5 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 CCF41797.1 - 0.089 12.6 0.1 0.089 12.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family MFS_1 PF07690.11 CCF41798.1 - 1.3e-41 142.5 46.4 3.8e-35 121.2 20.0 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily ESSS PF10183.4 CCF41798.1 - 0.0042 17.4 2.8 0.75 10.2 0.0 3.7 3 0 0 3 3 3 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) zf-RING_6 PF14835.1 CCF41798.1 - 0.0063 16.2 1.6 0.034 13.9 0.1 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein Xan_ur_permease PF00860.15 CCF41800.1 - 1.8e-07 30.0 2.8 2.4e-07 29.6 1.9 1.1 1 0 0 1 1 1 1 Permease family NESP55 PF06390.7 CCF41802.1 - 0.21 10.9 6.2 0.41 9.9 4.3 1.5 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) WD40 PF00400.27 CCF41804.1 - 2.4e-17 62.0 13.6 4.9e-08 32.5 0.8 6.8 8 0 0 8 8 8 4 WD domain, G-beta repeat DUF4379 PF14311.1 CCF41804.1 - 0.058 13.2 8.6 0.14 12.0 0.4 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4379) Atg14 PF10186.4 CCF41805.1 - 2.8e-18 65.9 0.0 4.8e-18 65.1 0.0 1.3 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 APG6 PF04111.7 CCF41805.1 - 0.003 16.6 7.4 0.48 9.4 4.5 2.4 3 0 0 3 3 3 2 Autophagy protein Apg6 DUF342 PF03961.8 CCF41805.1 - 0.045 12.1 2.2 0.072 11.5 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) COX2 PF00116.15 CCF41806.1 - 0.12 12.1 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, periplasmic domain Tom37 PF10568.4 CCF41807.1 - 1.7e-20 73.0 0.0 2.8e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein Tom37_C PF11801.3 CCF41807.1 - 2.5e-19 69.7 0.0 3.4e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 Tom37 C-terminal domain GST_C_2 PF13410.1 CCF41807.1 - 0.0039 17.0 0.0 0.015 15.1 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 CCF41807.1 - 0.069 13.3 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain TFR_dimer PF04253.10 CCF41808.1 - 7.9e-16 57.7 0.0 1.5e-15 56.8 0.0 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.12 CCF41808.1 - 6.8e-15 55.2 0.0 1.2e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 CCF41808.1 - 6.9e-07 28.8 0.3 5.2e-06 26.0 0.0 2.2 2 0 0 2 2 2 1 PA domain BCS1_N PF08740.6 CCF41810.1 - 6e-44 149.8 0.0 7.6e-44 149.5 0.0 1.1 1 0 0 1 1 1 1 BCS1 N terminal AAA_25 PF13481.1 CCF41810.1 - 4.4e-05 22.9 0.1 0.00028 20.3 0.0 2.2 2 1 1 3 3 3 1 AAA domain AAA PF00004.24 CCF41810.1 - 5.6e-05 23.3 0.0 0.0001 22.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CCF41810.1 - 0.00028 21.6 0.0 0.00079 20.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CCF41810.1 - 0.0016 18.3 0.0 0.0043 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 CCF41810.1 - 0.002 17.8 0.0 0.0044 16.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 CCF41810.1 - 0.0073 16.4 0.0 0.015 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 CCF41810.1 - 0.013 15.0 0.0 0.026 14.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.22 CCF41810.1 - 0.02 15.2 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.1 CCF41810.1 - 0.029 14.3 0.0 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.7 CCF41810.1 - 0.029 13.4 0.0 0.055 12.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Alpha_GJ PF03229.8 CCF41810.1 - 0.033 14.5 7.4 0.06 13.6 2.9 2.3 2 0 0 2 2 2 0 Alphavirus glycoprotein J DUF258 PF03193.11 CCF41810.1 - 0.044 12.9 0.0 0.079 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_18 PF13238.1 CCF41810.1 - 0.067 13.5 0.0 0.18 12.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 CCF41810.1 - 0.075 13.2 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AFOR_C PF01314.13 CCF41810.1 - 0.11 11.2 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 Aldehyde ferredoxin oxidoreductase, domains 2 & 3 Miro PF08477.8 CCF41810.1 - 0.11 12.9 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein ATP_bind_1 PF03029.12 CCF41810.1 - 0.13 11.7 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein KaiC PF06745.8 CCF41810.1 - 0.16 11.0 0.0 0.25 10.4 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_10 PF12846.2 CCF41810.1 - 0.17 11.3 0.0 0.32 10.3 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_21 PF13304.1 CCF41810.1 - 0.19 11.6 0.1 0.25 11.2 0.1 1.1 1 0 0 1 1 1 0 AAA domain DUF1232 PF06803.7 CCF41811.1 - 0.83 9.1 4.2 0.38 10.2 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1232) Epimerase PF01370.16 CCF41812.1 - 1e-15 57.8 0.0 2.3e-15 56.6 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF41812.1 - 3e-13 49.1 0.0 4.2e-13 48.6 0.0 1.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 CCF41812.1 - 4.3e-13 49.6 0.7 8.9e-13 48.6 0.5 1.6 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 CCF41812.1 - 3.9e-11 42.3 0.2 5.3e-09 35.3 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.8 CCF41812.1 - 4e-07 29.5 0.3 7.6e-07 28.6 0.2 1.5 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.20 CCF41812.1 - 1.4e-06 28.3 0.3 2.4e-06 27.5 0.2 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.10 CCF41812.1 - 0.00026 20.0 0.1 0.00036 19.5 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.5 CCF41812.1 - 0.00079 19.1 1.1 0.0081 15.8 0.7 2.1 1 1 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.12 CCF41812.1 - 0.009 14.9 0.1 0.013 14.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain DXP_reductoisom PF02670.11 CCF41812.1 - 0.043 14.3 0.1 0.083 13.4 0.0 1.5 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase DUF2850 PF11012.3 CCF41812.1 - 0.099 12.8 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2850) DUF1981 PF09324.5 CCF41813.1 - 4.3e-07 29.3 0.0 8.8e-05 21.9 0.0 2.9 2 0 0 2 2 2 2 Domain of unknown function (DUF1981) CDC37_M PF08565.6 CCF41814.1 - 1.5e-47 161.2 0.3 3.1e-47 160.2 0.2 1.4 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.5 CCF41814.1 - 5.4e-26 90.3 0.4 5.4e-26 90.3 0.3 2.6 2 1 0 2 2 2 1 Cdc37 C terminal domain CDC37_N PF03234.9 CCF41814.1 - 1.1e-13 51.8 0.8 1.1e-13 51.8 0.5 2.6 3 1 0 3 3 3 1 Cdc37 N terminal kinase binding MgtE_N PF03448.12 CCF41814.1 - 0.17 12.1 2.6 0.5 10.7 0.1 2.7 3 0 0 3 3 3 0 MgtE intracellular N domain DUF1268 PF06896.6 CCF41814.1 - 0.7 10.2 5.4 0.13 12.6 0.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1268) DUF3552 PF12072.3 CCF41814.1 - 0.76 8.9 10.8 0.066 12.4 3.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) Glyco_hydro_71 PF03659.9 CCF41815.1 - 9.2e-128 425.9 0.3 1.2e-127 425.6 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 Thioredoxin_7 PF13899.1 CCF41816.1 - 2.4e-15 56.3 0.0 5.5e-15 55.1 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.1 CCF41816.1 - 3.9e-15 55.0 1.5 5.7e-15 54.5 0.3 1.9 2 0 0 2 2 2 1 UBA-like domain UBX PF00789.15 CCF41816.1 - 3.8e-08 33.2 0.0 7e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 UBX domain Thioredox_DsbH PF03190.10 CCF41816.1 - 0.0018 18.0 0.0 0.0036 17.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF255 MIP-T3 PF10243.4 CCF41816.1 - 4.1 5.7 11.5 0.065 11.6 0.6 2.1 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 DAO PF01266.19 CCF41818.1 - 3.4e-56 190.7 0.3 3.9e-56 190.4 0.2 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF41818.1 - 6.4e-05 22.9 1.4 0.00011 22.0 0.1 2.1 2 1 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF41818.1 - 0.00017 21.7 0.0 0.67 9.9 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF41818.1 - 0.0048 16.6 0.1 0.049 13.4 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.12 CCF41818.1 - 0.021 13.9 0.0 0.033 13.2 0.0 1.3 1 0 0 1 1 1 0 Thi4 family DUF4147 PF13660.1 CCF41818.1 - 0.047 12.7 0.0 0.077 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4147) Lycopene_cycl PF05834.7 CCF41818.1 - 0.066 12.1 0.1 0.12 11.2 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein HI0933_like PF03486.9 CCF41818.1 - 0.076 11.4 0.0 0.99 7.8 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_2 PF00890.19 CCF41818.1 - 0.13 11.0 0.2 1.2 7.9 0.2 2.1 2 0 0 2 2 2 0 FAD binding domain Pyr_redox PF00070.22 CCF41818.1 - 0.16 12.3 0.2 1.7 9.1 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF41818.1 - 0.18 10.6 0.0 0.3 9.9 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Amino_oxidase PF01593.19 CCF41819.1 - 9.6e-61 206.2 0.0 1.2e-60 205.8 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 CCF41819.1 - 6.4e-09 35.7 0.2 3.3e-08 33.4 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF41819.1 - 0.00018 21.6 0.0 0.00041 20.4 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF41819.1 - 0.00031 19.6 0.0 0.00051 19.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.14 CCF41819.1 - 0.00067 18.8 0.5 0.0012 17.9 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF41819.1 - 0.0012 17.8 0.2 0.002 17.1 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 CCF41819.1 - 0.0081 14.6 0.0 0.014 13.8 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.12 CCF41819.1 - 0.019 14.0 0.2 0.036 13.1 0.1 1.4 1 0 0 1 1 1 0 Thi4 family Shikimate_DH PF01488.15 CCF41819.1 - 0.18 11.9 0.7 0.41 10.7 0.2 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Rhodanese PF00581.15 CCF41820.1 - 8.1e-05 22.9 0.0 0.00012 22.4 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain TRM PF02005.11 CCF41822.1 - 2.9e-106 355.5 0.0 8.6e-93 311.2 0.0 2.1 2 0 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_26 PF13659.1 CCF41822.1 - 0.013 15.4 1.1 0.54 10.3 0.7 2.5 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 CCF41822.1 - 0.015 14.6 0.1 0.043 13.1 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase small domain DUF1744 PF08490.7 CCF41823.1 - 2.9e-149 496.9 0.0 3.7e-149 496.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) AAA_22 PF13401.1 CCF41825.1 - 0.018 15.1 0.0 0.019 15.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain DUF3871 PF12987.2 CCF41825.1 - 0.15 10.7 0.2 0.15 10.7 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3871) Aminotran_5 PF00266.14 CCF41826.1 - 7.6e-11 41.3 0.0 1e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Abhydrolase_6 PF12697.2 CCF41827.1 - 1.3e-28 100.4 0.1 2e-28 99.8 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF41827.1 - 1.4e-11 44.3 0.1 2.9e-11 43.3 0.1 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF41827.1 - 0.005 16.4 0.0 0.0089 15.6 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF3089 PF11288.3 CCF41827.1 - 0.016 14.4 0.0 0.029 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Peptidase_S9 PF00326.16 CCF41827.1 - 0.042 13.0 0.0 4.7 6.3 0.0 3.2 3 1 1 4 4 4 0 Prolyl oligopeptidase family PGAP1 PF07819.8 CCF41827.1 - 0.088 12.3 0.0 0.15 11.5 0.0 1.6 1 1 0 1 1 1 0 PGAP1-like protein AATase PF07247.7 CCF41828.1 - 5.9e-16 58.0 0.0 8.5e-16 57.5 0.0 1.2 1 0 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.15 CCF41828.1 - 0.0026 16.6 0.0 1.6 7.4 0.0 2.2 2 0 0 2 2 2 2 Condensation domain UDPG_MGDP_dh PF00984.14 CCF41831.1 - 9.3e-30 102.7 0.0 1.9e-29 101.7 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.10 CCF41831.1 - 1.1e-21 76.9 0.0 2.4e-17 62.9 0.0 2.4 2 0 0 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PNP_UDP_1 PF01048.15 CCF41832.1 - 0.002 17.1 0.1 0.0022 17.0 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Acetyltransf_3 PF13302.1 CCF41833.1 - 6.7e-11 42.5 0.0 9.7e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 CCF41833.1 - 0.017 15.0 0.0 0.033 14.1 0.0 1.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CCF41833.1 - 0.029 14.3 0.0 0.051 13.6 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.1 CCF41833.1 - 0.065 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Glyco_hydro_43 PF04616.9 CCF41834.1 - 1e-65 221.6 0.0 1.3e-65 221.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 adh_short PF00106.20 CCF41835.1 - 4.4e-22 78.7 0.4 9e-22 77.7 0.3 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF41835.1 - 3.6e-12 46.2 0.5 7.4e-12 45.2 0.2 1.6 1 1 1 2 2 2 1 KR domain Epimerase PF01370.16 CCF41835.1 - 1.2e-05 24.8 0.1 1.8e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 CCF41835.1 - 0.0037 16.2 0.0 0.011 14.6 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Amidohydro_2 PF04909.9 CCF41835.1 - 0.0042 16.6 1.8 0.1 12.1 1.3 2.4 1 1 0 1 1 1 1 Amidohydrolase Shikimate_DH PF01488.15 CCF41835.1 - 0.019 15.1 0.0 0.04 14.0 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Saccharop_dh PF03435.13 CCF41835.1 - 0.025 13.5 0.0 0.037 13.0 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase Glyco_hydro_28 PF00295.12 CCF41836.1 - 9.8e-101 336.9 21.2 1.1e-100 336.7 14.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.1 CCF41836.1 - 0.003 17.3 27.2 0.088 12.5 12.3 3.0 1 1 1 2 2 2 2 Right handed beta helix region Helicase_C PF00271.26 CCF41837.1 - 5.5e-17 61.3 0.0 1.1e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 CCF41837.1 - 5.7e-06 25.3 0.0 8.3e-06 24.8 0.0 1.2 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 NpwBP PF12622.2 CCF41837.1 - 0.38 11.2 2.6 5.7 7.5 0.1 2.6 2 0 0 2 2 2 0 mRNA biogenesis factor Tyrosinase PF00264.15 CCF41838.1 - 1.6e-37 129.8 0.3 2.1e-37 129.4 0.2 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase HMG_box PF00505.14 CCF41838.1 - 0.09 13.0 0.1 0.16 12.2 0.1 1.3 1 0 0 1 1 1 0 HMG (high mobility group) box Fungal_trans PF04082.13 CCF41839.1 - 3.2e-05 22.9 0.0 6.2e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 CCF41840.1 - 0.15 12.4 11.3 0.48 10.8 1.1 3.5 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF41840.1 - 0.15 12.4 11.8 0.24 11.8 0.4 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger DUF719 PF05334.8 CCF41840.1 - 0.42 10.6 5.0 1.2 9.1 3.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF719) Med3 PF11593.3 CCF41840.1 - 6.5 5.8 16.9 1 8.4 6.3 2.2 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal DUF3661 PF12400.3 CCF41841.1 - 4.7 7.3 7.8 0.37 10.8 0.9 2.2 2 1 0 2 2 2 0 Vaculolar membrane protein ABC2_membrane PF01061.19 CCF41844.1 - 2.2e-46 157.6 17.8 3.1e-46 157.1 12.3 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_trans_N PF14510.1 CCF41844.1 - 6.6e-18 64.5 0.0 1.4e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal PDR_CDR PF06422.7 CCF41844.1 - 1.2e-15 57.0 0.0 2.9e-15 55.7 0.0 1.7 1 0 0 1 1 1 1 CDR ABC transporter ABC_tran PF00005.22 CCF41844.1 - 4.3e-14 52.9 0.0 9.8e-14 51.8 0.0 1.6 2 0 0 2 2 2 1 ABC transporter AAA_25 PF13481.1 CCF41844.1 - 0.047 13.0 0.0 0.092 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 CCF41844.1 - 0.11 12.4 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CCF41844.1 - 0.2 11.6 0.1 0.94 9.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain ABC2_membrane_3 PF12698.2 CCF41844.1 - 1.5 7.8 22.1 8.6 5.2 15.4 2.0 1 1 0 1 1 1 0 ABC-2 family transporter protein Peptidase_S49_N PF08496.5 CCF41845.1 - 0.19 11.4 0.6 0.24 11.2 0.4 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Pex14_N PF04695.8 CCF41845.1 - 0.84 9.6 10.1 1.2 9.2 7.0 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ndc1_Nup PF09531.5 CCF41845.1 - 1.5 7.1 4.3 1.6 7.0 3.0 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Gag_spuma PF03276.9 CCF41845.1 - 7.7 4.7 14.5 7.5 4.7 10.1 1.1 1 0 0 1 1 1 0 Spumavirus gag protein LysM PF01476.15 CCF41846.1 - 0.04 13.7 0.0 0.078 12.8 0.0 1.4 1 0 0 1 1 1 0 LysM domain Arv1 PF04161.8 CCF41847.1 - 2.1e-48 165.0 0.3 2.7e-48 164.6 0.2 1.1 1 0 0 1 1 1 1 Arv1-like family ATP_synt_H PF05493.8 CCF41848.1 - 1.5e-26 92.2 1.4 1.6e-26 92.1 1.0 1.0 1 0 0 1 1 1 1 ATP synthase subunit H DUF4131 PF13567.1 CCF41848.1 - 0.012 15.0 1.6 0.012 15.0 1.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) ARL6IP6 PF15062.1 CCF41848.1 - 0.027 14.3 0.1 0.037 13.9 0.1 1.4 1 1 0 1 1 1 0 Haemopoietic lineage transmembrane helix 7TMR-DISM_7TM PF07695.6 CCF41848.1 - 0.035 13.7 0.2 0.039 13.6 0.2 1.0 1 0 0 1 1 1 0 7TM diverse intracellular signalling Bax1-I PF01027.15 CCF41848.1 - 0.06 12.9 0.6 0.06 12.9 0.4 1.0 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 NAD_binding_2 PF03446.10 CCF41849.1 - 1.3e-25 90.1 0.2 2e-25 89.5 0.2 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 CCF41849.1 - 8.1e-12 45.2 0.4 1.8e-09 37.7 0.0 2.2 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.12 CCF41849.1 - 1.1e-07 32.2 0.0 3.4e-07 30.6 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 CCF41849.1 - 2.3e-07 30.9 0.1 4.3e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.13 CCF41849.1 - 1.6e-06 28.0 0.3 3.2e-06 27.1 0.0 1.6 2 0 0 2 2 2 1 TrkA-N domain NAD_binding_3 PF03447.11 CCF41849.1 - 0.0027 18.0 0.1 0.007 16.7 0.1 1.8 1 1 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.19 CCF41849.1 - 0.018 15.3 0.0 0.038 14.2 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain HTH_Tnp_Mu_2 PF09039.6 CCF41849.1 - 0.03 14.0 0.0 0.1 12.3 0.0 1.8 2 0 0 2 2 2 0 Mu DNA binding, I gamma subdomain 2-Hacid_dh_C PF02826.14 CCF41849.1 - 0.036 13.2 0.0 0.058 12.5 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain adh_short PF00106.20 CCF41849.1 - 0.046 13.6 1.5 0.059 13.2 0.1 1.9 3 0 0 3 3 3 0 short chain dehydrogenase GFO_IDH_MocA PF01408.17 CCF41849.1 - 0.046 14.2 0.0 0.1 13.1 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold DUF619 PF04768.8 CCF41850.1 - 5.3e-50 169.1 0.0 2e-49 167.3 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF619) Ribosomal_L3 PF00297.17 CCF41852.1 - 1.6e-09 37.5 0.1 2e-09 37.2 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L3 BUD22 PF09073.5 CCF41853.1 - 0.012 14.6 10.7 0.015 14.4 7.4 1.1 1 0 0 1 1 1 0 BUD22 PBP1_TM PF14812.1 CCF41853.1 - 0.022 15.0 4.7 0.022 15.0 3.2 2.9 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TFIIA PF03153.8 CCF41853.1 - 0.044 13.6 4.9 0.064 13.1 3.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ebola_NP PF05505.7 CCF41853.1 - 0.28 9.1 3.6 0.32 9.0 2.5 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein Cwf_Cwc_15 PF04889.7 CCF41853.1 - 0.3 10.7 11.8 0.38 10.4 8.2 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein FCP1_C PF09309.5 CCF41853.1 - 2.3 7.4 15.9 9.5 5.4 10.0 2.2 1 1 2 3 3 3 0 FCP1, C-terminal Daxx PF03344.10 CCF41853.1 - 2.6 6.4 13.5 3.1 6.1 9.4 1.1 1 0 0 1 1 1 0 Daxx Family PPP1R35_C PF15503.1 CCF41853.1 - 3.8 7.0 7.5 0.14 11.6 0.6 1.8 2 0 0 2 2 2 0 Protein phosphatase 1 regulatory subunit 35 C-terminus DDRGK PF09756.4 CCF41853.1 - 9.8 5.5 15.1 12 5.2 10.4 1.1 1 0 0 1 1 1 0 DDRGK domain Zn_clus PF00172.13 CCF41855.1 - 3.1e-05 23.7 12.0 5.3e-05 23.0 8.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SRR1 PF07985.7 CCF41855.1 - 0.0062 16.4 0.4 0.25 11.2 0.0 2.7 2 1 0 2 2 2 1 SRR1 Glyco_hydro_7 PF00840.15 CCF41856.1 - 1.1e-189 630.3 21.4 1.3e-189 630.1 14.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 DEC-1_N PF04625.8 CCF41858.1 - 1.1 7.8 9.8 1.2 7.7 6.8 1.0 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Mob1_phocein PF03637.12 CCF41859.1 - 8.5e-39 133.0 1.9 8.1e-21 74.4 0.0 2.1 2 0 0 2 2 2 2 Mob1/phocein family Epimerase PF01370.16 CCF41861.1 - 0.00022 20.7 0.0 0.00023 20.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF41861.1 - 0.00053 20.0 0.0 0.00056 19.9 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF41861.1 - 0.0029 16.9 0.0 0.0029 16.8 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.10 CCF41861.1 - 0.015 14.2 0.0 0.015 14.2 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 CCF41861.1 - 0.017 13.8 0.0 0.019 13.6 0.0 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 CCF41861.1 - 0.085 12.7 0.0 0.094 12.6 0.0 1.1 1 0 0 1 1 1 0 short chain dehydrogenase PHD PF00628.24 CCF41864.1 - 0.00065 19.3 8.3 0.0011 18.5 5.8 1.4 1 0 0 1 1 1 1 PHD-finger TYA PF01021.14 CCF41864.1 - 0.3 11.3 0.1 0.3 11.3 0.0 3.1 4 0 0 4 4 4 0 TYA transposon protein CoA_transf_3 PF02515.12 CCF41865.1 - 1.2e-60 204.0 0.0 3.7e-60 202.4 0.0 1.7 2 0 0 2 2 2 1 CoA-transferase family III Sigma70_r4 PF04545.11 CCF41865.1 - 0.015 14.6 0.1 0.033 13.5 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 ArsB PF02040.10 CCF41867.1 - 1.8e-15 56.8 20.9 3.5e-11 42.7 5.9 2.3 2 0 0 2 2 2 2 Arsenical pump membrane protein zf-C2H2 PF00096.21 CCF41868.1 - 0.015 15.6 2.1 0.015 15.6 1.4 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF41868.1 - 1.1 9.8 17.9 0.092 13.1 0.9 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger AMP-binding PF00501.23 CCF41869.1 - 1.3e-90 303.7 0.0 1.7e-90 303.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF41869.1 - 6.1e-10 39.9 1.5 8.3e-10 39.4 0.3 1.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Epimerase_Csub PF13950.1 CCF41870.1 - 0.081 12.8 0.1 0.17 11.8 0.0 1.6 2 0 0 2 2 2 0 UDP-glucose 4-epimerase C-term subunit FSH1 PF03959.8 CCF41871.1 - 1.5e-29 102.9 0.0 1.9e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 CCF41871.1 - 3.5e-05 23.5 0.3 6.3e-05 22.7 0.2 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 CCF41871.1 - 0.00047 19.7 0.2 0.00086 18.9 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 CCF41871.1 - 0.0046 16.4 1.4 0.12 11.8 0.4 2.4 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 CCF41871.1 - 0.0092 15.8 4.9 0.052 13.4 3.4 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family ELK PF03789.8 CCF41871.1 - 0.12 12.2 0.3 0.31 10.8 0.2 1.7 1 0 0 1 1 1 0 ELK domain Pkinase PF00069.20 CCF41872.1 - 6.2e-71 238.5 0.0 1e-70 237.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF41872.1 - 2.1e-51 174.5 0.0 3.2e-51 173.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF41872.1 - 0.0018 17.2 0.0 0.0039 16.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pal1 PF08316.6 CCF41873.1 - 1.3e-43 148.8 1.3 3.2e-43 147.5 0.9 1.7 1 0 0 1 1 1 1 Pal1 cell morphology protein UPF0546 PF10639.4 CCF41874.1 - 8.6e-37 125.4 0.1 1.1e-36 125.0 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0546 EamA PF00892.15 CCF41874.1 - 0.018 15.0 6.3 0.14 12.2 4.0 2.2 1 1 0 1 1 1 0 EamA-like transporter family TPT PF03151.11 CCF41874.1 - 0.53 9.9 4.4 1.2 8.7 3.1 1.4 1 1 0 1 1 1 0 Triose-phosphate Transporter family EmrE PF13536.1 CCF41874.1 - 6.7 6.9 9.1 0.23 11.6 2.3 1.5 2 0 0 2 2 2 0 Multidrug resistance efflux transporter DUF2011 PF09428.5 CCF41875.1 - 0.039 13.8 0.0 0.07 13.0 0.0 1.5 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2011) PCI PF01399.22 CCF41876.1 - 2e-18 66.6 0.2 7e-18 64.8 0.0 2.0 2 0 0 2 2 2 1 PCI domain PCI_Csn8 PF10075.4 CCF41876.1 - 3.2e-05 23.7 0.1 9e-05 22.2 0.1 1.7 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 TPR_7 PF13176.1 CCF41876.1 - 0.02 14.6 0.8 5.2 7.1 0.1 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 CCF41876.1 - 0.021 14.7 0.2 2 8.4 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 CCF41876.1 - 0.027 14.3 2.3 0.36 10.8 0.2 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 CCF41876.1 - 0.044 13.5 1.6 0.098 12.4 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 CCF41876.1 - 0.11 12.4 2.0 1.2 9.0 0.1 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat FeoC PF09012.5 CCF41876.1 - 0.12 12.0 0.0 0.32 10.7 0.0 1.7 1 0 0 1 1 1 0 FeoC like transcriptional regulator TPR_1 PF00515.23 CCF41876.1 - 0.15 11.7 1.8 1.1 9.0 0.1 3.1 4 0 0 4 4 4 0 Tetratricopeptide repeat CWC25 PF12542.3 CCF41877.1 - 3.5e-25 88.2 0.3 3.5e-25 88.2 0.2 2.6 2 1 1 3 3 3 1 Pre-mRNA splicing factor Cir_N PF10197.4 CCF41877.1 - 3.1e-13 49.4 9.4 3.1e-13 49.4 6.5 2.8 2 1 1 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR GGGtGRT PF14057.1 CCF41877.1 - 0.14 10.9 0.0 0.2 10.4 0.0 1.2 1 0 0 1 1 1 0 GGGtGRT protein DUF3674 PF12426.3 CCF41877.1 - 0.27 10.6 0.1 0.27 10.6 0.1 2.5 3 0 0 3 3 3 0 RNA dependent RNA polymerase FYVE_2 PF02318.11 CCF41877.1 - 2 8.3 6.6 3.9 7.4 4.6 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger Ank_2 PF12796.2 CCF41881.1 - 5.2e-60 199.7 7.2 5e-21 74.8 0.1 6.9 3 2 2 6 6 6 5 Ankyrin repeats (3 copies) Ank PF00023.25 CCF41881.1 - 1.2e-53 176.2 10.8 1.4e-09 37.2 0.0 10.9 9 2 1 10 10 10 7 Ankyrin repeat Ank_5 PF13857.1 CCF41881.1 - 4.2e-40 134.8 7.0 1.5e-10 40.9 0.1 7.4 3 2 5 8 8 8 6 Ankyrin repeats (many copies) Ank_4 PF13637.1 CCF41881.1 - 6.3e-39 131.6 6.8 1.3e-10 41.5 0.1 8.8 4 2 6 10 10 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF41881.1 - 9.6e-34 112.0 8.9 5e-05 23.1 0.0 11.8 10 1 1 11 11 11 6 Ankyrin repeat NACHT PF05729.7 CCF41881.1 - 2.3e-08 33.8 0.1 6.9e-08 32.3 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 CCF41881.1 - 1.5e-07 31.5 0.1 9.5e-07 28.9 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 CCF41881.1 - 1.1e-06 28.8 0.0 4.9e-06 26.7 0.0 2.1 1 0 0 1 1 1 1 AAA domain PNP_UDP_1 PF01048.15 CCF41881.1 - 3e-05 23.1 0.0 7.2e-05 21.8 0.0 1.6 1 0 0 1 1 1 1 Phosphorylase superfamily AAA_17 PF13207.1 CCF41881.1 - 0.00056 20.7 0.0 0.002 18.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.9 CCF41881.1 - 0.0026 16.8 0.7 0.19 10.6 0.2 2.2 1 1 1 2 2 2 1 KAP family P-loop domain AAA PF00004.24 CCF41881.1 - 0.007 16.5 0.0 0.13 12.5 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Glycos_transf_2 PF00535.21 CCF41881.1 - 0.011 15.4 0.0 0.027 14.1 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 AAA_10 PF12846.2 CCF41881.1 - 0.028 13.8 0.1 0.071 12.5 0.1 1.7 1 0 0 1 1 1 0 AAA-like domain AAA_30 PF13604.1 CCF41881.1 - 0.035 13.6 0.0 0.092 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 CCF41881.1 - 0.039 14.1 0.1 0.14 12.3 0.0 2.0 2 0 0 2 2 1 0 RNA helicase ABC_tran PF00005.22 CCF41881.1 - 0.042 14.1 0.0 0.5 10.6 0.0 2.4 2 0 0 2 2 2 0 ABC transporter AAA_18 PF13238.1 CCF41881.1 - 0.042 14.1 0.0 0.11 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.12 CCF41881.1 - 0.14 11.9 0.0 0.47 10.2 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_23 PF13476.1 CCF41881.1 - 0.22 11.8 0.0 0.55 10.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain CorA PF01544.13 CCF41882.1 - 0.00022 20.3 2.0 0.00095 18.2 1.4 1.9 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Mit_KHE1 PF10173.4 CCF41882.1 - 0.014 15.2 0.0 0.27 11.0 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related NAD_binding_6 PF08030.7 CCF41883.1 - 1.5e-17 63.9 0.0 2.3e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 CCF41883.1 - 1.3e-14 54.3 11.3 3e-14 53.2 7.8 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 CCF41883.1 - 1.4e-06 28.1 0.0 8.3e-06 25.6 0.0 2.1 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.16 CCF41883.1 - 1.4e-06 28.7 0.0 0.0024 18.4 0.0 2.5 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain VanZ PF04892.7 CCF41884.1 - 2e-11 44.0 3.3 2.6e-11 43.6 2.3 1.1 1 0 0 1 1 1 1 VanZ like family Cation_efflux PF01545.16 CCF41885.1 - 0.00045 19.3 0.0 0.00055 19.0 0.0 1.1 1 0 0 1 1 1 1 Cation efflux family MRP-L27 PF09809.4 CCF41886.1 - 1.1e-16 60.3 0.5 1.5e-16 59.9 0.3 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 Zip PF02535.17 CCF41888.1 - 0.069 12.1 0.2 0.07 12.1 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF385 PF04075.9 CCF41889.1 - 0.077 12.9 0.0 0.09 12.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF385) DmpG_comm PF07836.6 CCF41889.1 - 0.14 11.6 0.0 0.45 9.9 0.0 1.8 2 0 0 2 2 2 0 DmpG-like communication domain P5CR_dimer PF14748.1 CCF41890.1 - 5.7e-38 129.2 0.1 5.7e-38 129.2 0.1 2.6 4 1 0 4 4 4 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.12 CCF41890.1 - 5.2e-18 65.2 3.1 1.6e-17 63.7 2.1 1.9 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.10 CCF41890.1 - 0.00085 19.2 0.6 0.0017 18.2 0.4 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.18 CCF41890.1 - 0.0041 16.8 6.9 0.081 12.6 3.5 2.8 2 1 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus CoA_binding PF02629.14 CCF41890.1 - 0.0093 16.4 0.7 0.031 14.7 0.5 1.9 1 0 0 1 1 1 1 CoA binding domain Shikimate_DH PF01488.15 CCF41890.1 - 0.03 14.4 0.3 0.067 13.3 0.1 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NMT1_2 PF13379.1 CCF41890.1 - 0.11 11.8 2.2 0.7 9.2 0.0 2.4 2 1 0 3 3 3 0 NMT1-like family Hexapep_2 PF14602.1 CCF41892.1 - 1.5e-17 62.8 20.1 8.1e-10 38.0 3.9 2.5 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.19 CCF41892.1 - 3e-15 54.9 19.1 3.5e-10 38.9 3.5 3.4 3 1 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Mac PF12464.3 CCF41892.1 - 1.1e-12 47.7 0.0 3.5e-12 46.1 0.0 1.8 1 0 0 1 1 1 1 Maltose acetyltransferase Zn_clus PF00172.13 CCF41892.1 - 1.1e-09 38.0 8.6 2.1e-09 37.1 6.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ABC_membrane_2 PF06472.10 CCF41893.1 - 1.3e-98 329.6 0.9 1.6e-98 329.3 0.1 1.5 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 CCF41893.1 - 6.2e-16 58.9 0.0 1.1e-15 58.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_17 PF13207.1 CCF41893.1 - 0.0082 16.9 0.0 0.023 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.1 CCF41893.1 - 0.0095 15.9 0.0 0.025 14.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 CCF41893.1 - 0.016 15.3 0.0 0.035 14.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 CCF41893.1 - 0.022 13.7 0.0 0.047 12.7 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus Mg_chelatase PF01078.16 CCF41893.1 - 0.031 13.4 0.1 0.053 12.6 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.1 CCF41893.1 - 0.037 13.9 0.0 0.083 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Sigma54_activat PF00158.21 CCF41893.1 - 0.062 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.1 CCF41893.1 - 0.086 12.8 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_22 PF13401.1 CCF41893.1 - 0.087 12.9 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 CCF41893.1 - 0.13 12.0 0.0 0.35 10.6 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain IstB_IS21 PF01695.12 CCF41893.1 - 0.13 11.6 0.0 0.38 10.1 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein T2SE PF00437.15 CCF41893.1 - 0.19 10.5 0.0 0.31 9.9 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein G-patch PF01585.18 CCF41894.1 - 1e-05 25.2 0.0 4e-05 23.3 0.0 2.1 1 1 0 1 1 1 1 G-patch domain CDC27 PF09507.5 CCF41894.1 - 0.0014 17.9 57.6 0.002 17.4 39.9 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 CAF-1_p150 PF11600.3 CCF41894.1 - 1.1 8.5 77.8 1.6 8.0 53.9 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal MIP-T3 PF10243.4 CCF41894.1 - 2.6 6.4 72.3 3.6 5.9 50.1 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 COX17 PF05051.8 CCF41895.1 - 7.9e-20 70.6 5.7 9.4e-20 70.3 4.0 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) RRM_1 PF00076.17 CCF41897.1 - 1.8e-13 49.8 0.0 2e-06 27.3 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF41897.1 - 1.4e-12 47.3 0.1 2.7e-05 24.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF41897.1 - 6.5e-07 29.0 0.0 3.1e-06 26.9 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2201_N PF13203.1 CCF41897.1 - 3 6.9 7.5 0.65 9.1 0.6 2.3 2 0 0 2 2 2 0 Putative metallopeptidase domain Pkinase PF00069.20 CCF41898.1 - 1.2e-51 175.4 0.2 9.1e-36 123.3 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CCF41898.1 - 4.1e-22 78.4 0.5 6.7e-20 71.2 0.2 3.5 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF41898.1 - 1.6e-05 23.9 0.0 6.3e-05 22.0 0.0 1.8 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 CCF41898.1 - 0.0012 18.6 0.1 0.0049 16.6 0.0 2.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Clathrin PF00637.15 CCF41899.1 - 5.2e-24 84.4 4.0 1.4e-22 79.8 0.5 2.6 3 0 0 3 3 3 1 Region in Clathrin and VPS VPS11_C PF12451.3 CCF41899.1 - 8.9e-20 70.2 0.1 3.3e-19 68.4 0.0 2.0 2 0 0 2 2 2 1 Vacuolar protein sorting protein 11 C terminal zf-RING_2 PF13639.1 CCF41899.1 - 0.0039 16.9 8.1 0.01 15.6 5.6 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 CCF41899.1 - 0.0074 15.9 6.7 0.016 14.9 4.6 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_1 PF14446.1 CCF41899.1 - 0.062 13.0 3.5 0.14 11.8 2.4 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Curto_V2 PF07325.6 CCF41899.1 - 0.11 12.1 1.0 0.25 10.9 0.7 1.5 1 0 0 1 1 1 0 Curtovirus V2 protein zf-Apc11 PF12861.2 CCF41899.1 - 0.17 11.7 1.5 0.52 10.1 1.1 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 CCF41899.1 - 0.19 11.8 2.3 0.46 10.6 1.6 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 CCF41899.1 - 0.21 11.6 11.3 0.086 12.8 4.8 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF41899.1 - 2.5 7.8 11.3 0.55 9.9 4.9 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_6 PF14599.1 CCF41900.1 - 3.5e-25 87.5 0.0 3.5e-25 87.5 0.0 4.3 3 1 0 3 3 3 1 Zinc-ribbon zf-CHY PF05495.7 CCF41900.1 - 1.3e-16 60.5 20.4 1.3e-16 60.5 14.1 4.3 3 1 1 4 4 4 1 CHY zinc finger zf-RING_2 PF13639.1 CCF41900.1 - 2.1e-08 33.8 9.2 2.1e-08 33.8 6.4 5.5 3 1 1 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.1 CCF41900.1 - 5.5e-07 29.5 7.4 5.5e-07 29.5 5.2 5.5 3 2 3 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF41900.1 - 1.9e-05 24.2 7.7 1.9e-05 24.2 5.3 7.1 3 2 2 5 5 5 1 zinc-RING finger domain MOZART1 PF12554.3 CCF41901.1 - 2.4e-27 94.1 0.8 2.9e-27 93.8 0.6 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated Rrn6 PF10214.4 CCF41902.1 - 1.4e-65 221.8 28.6 1.9e-63 214.8 0.0 3.1 2 1 0 3 3 3 2 RNA polymerase I-specific transcription-initiation factor Urocanase PF01175.13 CCF41902.1 - 0.31 9.0 0.0 0.46 8.4 0.0 1.1 1 0 0 1 1 1 0 Urocanase PITH PF06201.8 CCF41903.1 - 1.4e-45 154.7 0.0 1.7e-45 154.4 0.0 1.1 1 0 0 1 1 1 1 PITH domain RRM_5 PF13893.1 CCF41904.1 - 4.2e-07 29.7 0.0 7.8e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CCF41904.1 - 1.7e-06 27.5 0.0 3.1e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF41904.1 - 1e-05 25.4 0.0 2.1e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.8 CCF41904.1 - 0.00042 20.4 0.0 0.0013 18.9 0.0 1.9 1 1 0 1 1 1 1 RNA polymerase II-binding domain. RRM_3 PF08777.6 CCF41904.1 - 0.037 13.8 0.0 0.1 12.4 0.0 1.6 2 0 0 2 2 2 0 RNA binding motif Citrate_synt PF00285.16 CCF41905.1 - 1.1e-102 343.4 0.0 1.3e-102 343.1 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase Eclosion PF04736.7 CCF41905.1 - 0.011 15.1 0.0 0.023 14.1 0.0 1.5 1 0 0 1 1 1 0 Eclosion hormone DAO PF01266.19 CCF41906.1 - 9.8e-39 133.2 0.1 1.4e-38 132.7 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 CCF41906.1 - 0.00011 22.0 0.2 0.13 12.0 0.0 3.2 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 CCF41906.1 - 0.00027 20.8 0.0 0.96 9.2 0.0 3.3 2 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF41906.1 - 0.034 12.7 0.1 0.18 10.3 0.0 1.9 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_7 PF13241.1 CCF41906.1 - 0.074 13.3 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox_3 PF13738.1 CCF41906.1 - 0.082 12.9 0.0 1 9.3 0.0 2.4 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DHBP_synthase PF00926.14 CCF41907.1 - 6.3e-05 22.2 0.0 7.6e-05 22.0 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase CHAP PF05257.11 CCF41907.1 - 0.1 12.2 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 CHAP domain NatB_MDM20 PF09797.4 CCF41907.1 - 0.11 11.2 0.0 0.11 11.2 0.0 1.0 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit p450 PF00067.17 CCF41908.1 - 1.7e-49 168.6 0.0 1.1e-35 123.0 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Urb2 PF10441.4 CCF41909.1 - 0.043 13.3 0.0 0.069 12.7 0.0 1.4 1 0 0 1 1 1 0 Urb2/Npa2 family DUF605 PF04652.11 CCF41909.1 - 0.056 12.8 29.5 0.07 12.5 20.4 1.1 1 0 0 1 1 1 0 Vta1 like DltD_M PF04918.7 CCF41909.1 - 0.12 12.5 1.1 0.21 11.7 0.8 1.4 1 0 0 1 1 1 0 DltD central region DUF3141 PF11339.3 CCF41909.1 - 0.13 10.5 5.8 0.16 10.2 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) Hid1 PF12722.2 CCF41909.1 - 1.7 6.1 9.5 2.3 5.7 6.6 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ADH_zinc_N PF00107.21 CCF41910.1 - 1.3e-20 73.2 0.0 2.1e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF41910.1 - 1.9e-08 35.2 0.0 4.3e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FA_desaturase PF00487.19 CCF41912.1 - 1.2e-39 136.3 18.4 1.6e-39 135.9 12.7 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 CCF41912.1 - 3.5e-10 39.5 0.0 7.4e-10 38.4 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ASL_C2 PF14698.1 CCF41913.1 - 0.00026 20.9 0.1 0.00036 20.5 0.1 1.2 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Na_H_Exchanger PF00999.16 CCF41916.1 - 3.2e-69 233.2 48.8 4.6e-69 232.7 33.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family F-box-like PF12937.2 CCF41918.1 - 0.065 12.9 0.1 0.21 11.3 0.1 1.9 1 0 0 1 1 1 0 F-box-like Peptidase_M3 PF01432.15 CCF41919.1 - 9.4e-156 519.4 0.0 1.2e-155 519.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M91 PF14891.1 CCF41919.1 - 0.017 15.1 0.0 0.043 13.8 0.0 1.6 1 0 0 1 1 1 0 Effector protein EF-hand_7 PF13499.1 CCF41920.1 - 2.1e-15 56.5 0.3 2.1e-10 40.5 0.2 2.2 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 CCF41920.1 - 1.3e-11 43.3 0.4 0.00097 18.8 0.0 3.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_9 PF14658.1 CCF41920.1 - 1.8e-10 40.6 0.0 0.00013 21.7 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 CCF41920.1 - 4.6e-10 38.0 0.5 0.012 14.8 0.0 4.1 4 1 0 4 4 4 2 EF hand EF-hand_8 PF13833.1 CCF41920.1 - 4.1e-08 32.7 1.0 0.00041 19.8 0.1 3.5 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.1 CCF41920.1 - 0.029 13.7 1.2 2.2 7.7 0.7 3.2 3 0 0 3 3 3 0 EF hand DUF3216 PF11505.3 CCF41920.1 - 0.14 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3216) HET PF06985.6 CCF41923.1 - 7.2e-19 68.3 0.0 1.7e-18 67.1 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Asp PF00026.18 CCF41924.1 - 7.8e-56 189.6 0.0 9.6e-56 189.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CCF41924.1 - 9.2e-10 38.7 0.0 7e-09 35.8 0.0 2.2 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Serglycin PF04360.7 CCF41924.1 - 0.1 12.3 0.2 0.19 11.4 0.2 1.4 1 0 0 1 1 1 0 Serglycin Ribonuc_L-PSP PF01042.16 CCF41925.1 - 2.9e-16 59.3 0.0 3.5e-16 59.0 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP Sulfotransfer_3 PF13469.1 CCF41926.1 - 0.075 13.9 0.4 1.2 10.0 0.3 2.6 1 1 0 1 1 1 0 Sulfotransferase family Ribosomal_L27 PF01016.14 CCF41928.1 - 2e-22 78.7 0.0 3.5e-22 77.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal L27 protein Mhr1 PF12829.2 CCF41928.1 - 0.51 10.1 4.0 0.8 9.5 0.1 2.3 1 1 1 2 2 2 0 Transcriptional regulation of mitochondrial recombination Rad4 PF03835.10 CCF41929.1 - 2.4e-15 56.1 2.8 4.2e-15 55.4 2.0 1.3 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.14 CCF41929.1 - 2.3e-11 43.9 1.9 4.6e-11 42.9 1.3 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily p450 PF00067.17 CCF41930.1 - 4.6e-49 167.1 0.0 8.1e-49 166.3 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.11 CCF41931.1 - 3.3e-41 141.1 57.9 4.9e-39 134.0 39.0 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily OTT_1508_deam PF14441.1 CCF41933.1 - 0.00015 21.5 0.0 0.00035 20.3 0.0 1.6 1 0 0 1 1 1 1 OTT_1508-like deaminase COG5 PF10392.4 CCF41933.1 - 0.045 13.7 0.1 0.64 9.9 0.0 2.2 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Gln-synt_C PF00120.19 CCF41935.1 - 1.3e-52 178.5 0.0 1.9e-52 177.9 0.0 1.2 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Amidohydro_2 PF04909.9 CCF41935.1 - 1e-27 97.4 0.4 2.5e-27 96.1 0.2 1.8 2 0 0 2 2 2 1 Amidohydrolase Dynamin_N PF00350.18 CCF41936.1 - 7.1e-21 74.7 0.0 5.5e-20 71.8 0.0 2.3 1 1 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 CCF41936.1 - 1e-10 40.8 0.1 1.7e-06 27.0 0.0 2.2 2 0 0 2 2 2 2 Dynamin central region GED PF02212.13 CCF41936.1 - 6.7e-06 25.9 0.1 3.2e-05 23.7 0.0 2.1 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 CCF41936.1 - 0.011 15.6 0.0 7.5 6.5 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Miro PF08477.8 CCF41936.1 - 0.07 13.6 0.0 0.24 11.9 0.0 1.9 1 0 0 1 1 1 0 Miro-like protein Sugar_tr PF00083.19 CCF41937.1 - 2.4e-81 273.5 22.0 2.8e-81 273.4 15.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF41937.1 - 1.2e-25 90.0 20.5 1.7e-25 89.4 14.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Methyltransf_23 PF13489.1 CCF41938.1 - 3.9e-12 46.1 0.0 6.1e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF41938.1 - 2.3e-05 24.7 0.0 5.6e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF41938.1 - 0.0001 22.6 0.0 0.00035 20.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF41938.1 - 0.094 13.2 0.0 0.76 10.3 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.11 CCF41939.1 - 3.1e-16 59.0 8.2 3.7e-16 58.7 5.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF41939.1 - 4e-09 35.5 0.5 4.6e-09 35.3 0.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter DUF1228 PF06779.9 CCF41939.1 - 0.0082 16.1 1.5 0.012 15.5 1.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1228) MFS_2 PF13347.1 CCF41939.1 - 0.077 11.3 4.4 0.11 10.8 3.0 1.3 1 0 0 1 1 1 0 MFS/sugar transport protein Ceramidase_alk PF04734.8 CCF41940.1 - 1e-268 892.8 0.0 1.1e-268 892.6 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase nec1 PF10379.4 CCF41941.1 - 0.13 11.5 0.8 0.15 11.2 0.6 1.1 1 0 0 1 1 1 0 Virulence protein nec1 Transferase PF02458.10 CCF41942.1 - 5e-20 71.3 0.0 1.4e-16 59.9 0.0 2.9 2 1 0 2 2 2 2 Transferase family Condensation PF00668.15 CCF41942.1 - 0.023 13.5 0.0 0.039 12.8 0.0 1.2 1 0 0 1 1 1 0 Condensation domain BTB PF00651.26 CCF41943.1 - 2e-07 30.9 0.0 3.1e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF2347 PF09804.4 CCF41945.1 - 0.017 14.4 1.0 0.02 14.1 0.7 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) PEHE PF15275.1 CCF41945.1 - 0.018 15.5 3.9 0.019 15.3 2.7 1.1 1 0 0 1 1 1 0 PEHE domain Peptidase_S49_N PF08496.5 CCF41945.1 - 0.029 14.1 4.2 0.032 14.0 2.9 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Topoisom_I_N PF02919.10 CCF41945.1 - 0.06 12.6 6.3 0.066 12.5 4.4 1.0 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment DUF945 PF06097.6 CCF41945.1 - 0.078 11.7 2.6 0.092 11.5 1.8 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) BRF1 PF07741.8 CCF41945.1 - 0.08 13.1 5.5 0.083 13.1 3.8 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Med19 PF10278.4 CCF41945.1 - 0.14 11.8 8.2 0.16 11.6 5.7 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 TraV PF09676.5 CCF41945.1 - 0.49 11.1 3.3 0.55 10.9 2.3 1.1 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) DDRGK PF09756.4 CCF41945.1 - 0.58 9.5 12.2 0.64 9.4 8.4 1.1 1 0 0 1 1 1 0 DDRGK domain PEX11 PF05648.9 CCF41945.1 - 0.75 9.0 2.8 0.8 8.9 1.9 1.1 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) PsiA PF06952.6 CCF41945.1 - 0.76 8.7 6.4 0.83 8.6 4.4 1.1 1 0 0 1 1 1 0 PsiA protein Radial_spoke_3 PF06098.6 CCF41945.1 - 1.4 7.8 11.5 1.6 7.6 8.0 1.0 1 0 0 1 1 1 0 Radial spoke protein 3 NARP1 PF12569.3 CCF41945.1 - 1.4 7.5 10.4 1.6 7.3 7.2 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Iron_permease PF04120.7 CCF41945.1 - 2.5 7.7 5.6 3.2 7.3 3.9 1.2 1 0 0 1 1 1 0 Low affinity iron permease DUF2098 PF09871.4 CCF41945.1 - 2.6 8.0 5.7 3.2 7.7 3.9 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) MscS_TM PF12794.2 CCF41945.1 - 4.4 5.8 6.4 5.1 5.5 4.5 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 COesterase PF00135.23 CCF41946.1 - 4.6e-101 339.1 0.1 5.1e-101 339.0 0.1 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF41946.1 - 4.6e-05 23.0 0.0 8.1e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF41946.1 - 0.0048 16.1 0.3 0.008 15.4 0.2 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CCF41946.1 - 0.029 14.1 0.0 0.047 13.4 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family DCAF15_WD40 PF14939.1 CCF41946.1 - 0.14 11.4 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 DDB1-and CUL4-substrate receptor 15, WD repeat GMC_oxred_N PF00732.14 CCF41948.1 - 1.9e-42 145.4 0.0 5.6e-42 143.9 0.0 1.7 1 1 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 CCF41948.1 - 3.2e-05 22.9 0.2 0.063 12.1 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 CCF41948.1 - 4.6e-05 22.5 0.6 0.0023 16.9 0.4 2.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 CCF41948.1 - 0.0049 15.8 0.0 0.0079 15.1 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 CCF41948.1 - 0.013 15.5 0.3 0.052 13.5 0.1 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 CCF41948.1 - 0.021 13.9 0.0 0.04 13.0 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.9 CCF41948.1 - 0.056 12.0 0.1 0.075 11.6 0.1 1.1 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox_3 PF13738.1 CCF41948.1 - 0.06 13.4 0.2 3.4 7.6 0.1 2.3 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF41948.1 - 0.063 11.7 0.0 0.096 11.1 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Acetyltransf_1 PF00583.19 CCF41950.1 - 6.4e-16 58.1 0.2 9.3e-16 57.6 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 CCF41950.1 - 8.1e-10 38.8 0.0 9.8e-10 38.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 CCF41950.1 - 4.2e-05 23.7 0.0 5.4e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 CCF41950.1 - 0.00023 21.0 0.0 0.00045 20.1 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF41950.1 - 0.00027 20.6 0.0 0.00043 19.9 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.1 CCF41950.1 - 0.0012 18.9 0.0 0.0018 18.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 CCF41950.1 - 0.016 15.1 0.0 0.022 14.7 0.0 1.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 CCF41950.1 - 0.023 14.5 0.0 0.037 13.9 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase MFS_1 PF07690.11 CCF41951.1 - 2.1e-05 23.3 7.1 3e-05 22.9 4.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily SKG6 PF08693.5 CCF41951.1 - 0.057 12.7 0.6 5.2 6.4 0.0 2.9 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Fungal_trans PF04082.13 CCF41954.1 - 5.3e-17 61.5 0.0 9.4e-17 60.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41954.1 - 4.1e-08 33.0 12.9 4.1e-08 33.0 8.9 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BRK PF07533.11 CCF41954.1 - 0.002 17.5 0.0 0.0041 16.5 0.0 1.4 1 0 0 1 1 1 1 BRK domain Dickkopf_N PF04706.7 CCF41954.1 - 0.13 12.4 7.2 0.44 10.7 5.0 1.9 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region PepX_C PF08530.5 CCF41956.1 - 2.3e-31 109.3 0.0 3.7e-31 108.7 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain EthD PF07110.6 CCF41956.1 - 0.00014 22.7 0.0 0.0006 20.6 0.0 2.1 2 0 0 2 2 2 1 EthD domain Peptidase_S15 PF02129.13 CCF41956.1 - 0.00044 19.7 0.1 0.00078 18.9 0.1 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) DUF4440 PF14534.1 CCF41957.1 - 4.3e-10 39.7 0.0 5.2e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) RNA_Me_trans PF04252.8 CCF41959.1 - 2.6e-48 164.0 0.0 3e-48 163.8 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase DUF1680 PF07944.7 CCF41960.1 - 5e-94 315.4 0.0 6.9e-94 314.9 0.0 1.0 1 0 0 1 1 1 1 Putative glycosyl hydrolase of unknown function (DUF1680) DUF2934 PF11154.3 CCF41960.1 - 3.4 7.0 6.3 15 5.0 0.7 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2934) ABC_tran PF00005.22 CCF41961.1 - 2.1e-41 141.4 0.1 1.6e-20 73.7 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.18 CCF41961.1 - 1.4e-24 87.0 15.0 1.4e-24 87.0 10.4 1.9 2 0 0 2 2 2 1 ABC transporter transmembrane region AAA_21 PF13304.1 CCF41961.1 - 3.8e-14 53.3 0.1 0.019 14.9 0.2 4.2 2 2 0 4 4 4 4 AAA domain SMC_N PF02463.14 CCF41961.1 - 7.7e-09 35.1 0.6 0.007 15.6 0.1 4.2 3 1 0 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 CCF41961.1 - 2.2e-06 27.0 0.1 0.096 12.2 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 CCF41961.1 - 2.8e-05 24.2 0.2 0.042 14.0 0.0 3.0 3 1 0 3 3 2 1 AAA domain AAA_23 PF13476.1 CCF41961.1 - 4.2e-05 23.9 0.1 0.1 12.9 0.1 2.2 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 CCF41961.1 - 8e-05 22.5 0.2 0.58 10.1 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_25 PF13481.1 CCF41961.1 - 0.00011 21.6 0.1 0.24 10.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain Miro PF08477.8 CCF41961.1 - 0.00018 22.0 0.0 0.22 12.0 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein AAA_18 PF13238.1 CCF41961.1 - 0.00022 21.5 0.1 1.1 9.5 0.0 2.9 3 0 0 3 3 2 2 AAA domain MobB PF03205.9 CCF41961.1 - 0.00027 20.6 0.2 0.6 9.7 0.0 2.7 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 CCF41961.1 - 0.00027 20.8 0.0 0.063 13.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 CCF41961.1 - 0.00029 21.6 0.1 0.94 10.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.18 CCF41961.1 - 0.0005 19.9 0.6 0.12 12.1 0.0 2.3 2 0 0 2 2 2 1 Dynamin family DUF258 PF03193.11 CCF41961.1 - 0.00054 19.1 0.1 1 8.5 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_10 PF12846.2 CCF41961.1 - 0.0008 18.9 0.3 0.92 8.8 0.0 2.7 3 0 0 3 3 3 2 AAA-like domain T2SE PF00437.15 CCF41961.1 - 0.0018 17.2 0.0 0.27 10.0 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 CCF41961.1 - 0.0063 16.0 0.0 0.32 10.4 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_16 PF13191.1 CCF41961.1 - 0.0081 16.1 1.5 0.83 9.6 0.1 2.5 2 0 0 2 2 2 1 AAA ATPase domain DUF87 PF01935.12 CCF41961.1 - 0.016 15.0 0.0 0.031 14.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 Zeta_toxin PF06414.7 CCF41961.1 - 0.045 12.8 0.1 6 5.9 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin cobW PF02492.14 CCF41961.1 - 0.053 12.9 0.6 6 6.2 0.3 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.1 CCF41961.1 - 0.099 12.5 0.0 3.4 7.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain Arch_ATPase PF01637.13 CCF41961.1 - 0.1 12.2 0.0 6.5 6.3 0.0 2.3 2 0 0 2 2 2 0 Archaeal ATPase ABC_ATPase PF09818.4 CCF41961.1 - 0.62 8.5 3.4 0.42 9.1 0.1 2.2 3 0 0 3 3 3 0 Predicted ATPase of the ABC class AMP-binding PF00501.23 CCF41962.1 - 6.7e-158 525.4 0.0 1.4e-77 260.9 0.0 3.5 4 0 0 4 4 4 3 AMP-binding enzyme Condensation PF00668.15 CCF41962.1 - 4.4e-82 275.2 0.0 7.9e-43 146.4 0.0 3.3 3 0 0 3 3 3 3 Condensation domain PP-binding PF00550.20 CCF41962.1 - 2.8e-28 97.9 0.2 5.3e-13 49.0 0.0 3.3 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.1 CCF41962.1 - 1.2e-13 51.8 0.9 2.2e-05 25.3 0.1 3.2 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain Csm1 PF12539.3 CCF41962.1 - 0.41 11.1 0.1 35 4.9 0.0 2.5 2 0 0 2 2 2 0 Chromosome segregation protein Csm1/Pcs1 DUF2884 PF11101.3 CCF41962.1 - 0.98 8.7 0.2 7.6 5.8 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2884) Cation_efflux PF01545.16 CCF41963.1 - 4.9e-61 206.2 1.3 6.5e-61 205.8 0.9 1.1 1 0 0 1 1 1 1 Cation efflux family Zip PF02535.17 CCF41963.1 - 0.082 11.8 57.5 0.84 8.5 11.3 3.4 1 1 1 2 2 2 0 ZIP Zinc transporter Herpes_gE PF02480.11 CCF41965.1 - 0.00028 19.3 0.1 0.00041 18.7 0.1 1.3 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E Rax2 PF12768.2 CCF41965.1 - 0.0004 19.6 0.4 0.00062 19.0 0.3 1.2 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Podoplanin PF05808.6 CCF41965.1 - 0.026 14.0 1.3 0.052 13.1 0.9 1.4 1 0 0 1 1 1 0 Podoplanin VSP PF03302.8 CCF41965.1 - 0.09 11.3 0.1 0.11 11.1 0.1 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein MgtE PF01769.11 CCF41965.1 - 0.21 11.8 2.4 0.44 10.8 1.7 1.5 1 1 0 1 1 1 0 Divalent cation transporter CcmD PF04995.9 CCF41965.1 - 1.5 8.6 7.7 1.6 8.5 2.1 2.4 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) Lamp PF01299.12 CCF41965.1 - 2 7.4 10.1 0.3 10.2 2.2 2.1 1 1 1 2 2 2 0 Lysosome-associated membrane glycoprotein (Lamp) Toxin_35 PF10530.4 CCF41968.1 - 0.12 12.5 4.9 3.8 7.6 0.5 2.3 2 0 0 2 2 2 0 Toxin with inhibitor cystine knot ICK or Knottin scaffold KAP_NTPase PF07693.9 CCF41969.1 - 3.6e-06 26.2 0.0 3.6e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 KAP family P-loop domain AAA_17 PF13207.1 CCF41969.1 - 5.7e-06 27.1 0.0 6.7e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF41969.1 - 0.0002 21.3 0.0 0.0002 21.3 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain ArgK PF03308.11 CCF41969.1 - 0.0011 17.8 0.1 0.0022 16.8 0.0 1.4 2 0 0 2 2 2 1 ArgK protein AAA_33 PF13671.1 CCF41969.1 - 0.0013 18.5 0.0 0.0016 18.3 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 CCF41969.1 - 0.0014 18.7 0.0 0.0015 18.7 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CCF41969.1 - 0.0049 16.9 0.0 0.0053 16.8 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 CCF41969.1 - 0.0057 16.6 0.0 0.0063 16.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 CCF41969.1 - 0.0065 16.3 0.0 0.0071 16.2 0.0 1.2 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 CCF41969.1 - 0.0086 15.6 0.0 0.0092 15.5 0.0 1.1 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase Arch_ATPase PF01637.13 CCF41969.1 - 0.009 15.7 0.0 0.014 15.1 0.0 1.3 1 1 0 1 1 1 1 Archaeal ATPase RNA_helicase PF00910.17 CCF41969.1 - 0.0091 16.1 0.0 0.0097 16.0 0.0 1.2 1 0 0 1 1 1 1 RNA helicase Zeta_toxin PF06414.7 CCF41969.1 - 0.011 14.8 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin Torsin PF06309.6 CCF41969.1 - 0.011 15.6 0.0 0.012 15.5 0.0 1.2 1 0 0 1 1 1 0 Torsin AAA_18 PF13238.1 CCF41969.1 - 0.014 15.6 0.0 0.016 15.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain Virul_Fac PF10139.4 CCF41969.1 - 0.022 12.7 0.0 0.028 12.3 0.0 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor ABC_tran PF00005.22 CCF41969.1 - 0.028 14.7 0.0 0.033 14.4 0.0 1.3 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.7 CCF41969.1 - 0.036 13.7 0.0 0.053 13.1 0.0 1.2 1 0 0 1 1 1 0 NACHT domain MMR_HSR1 PF01926.18 CCF41969.1 - 0.037 13.9 0.0 0.073 13.0 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase NB-ARC PF00931.17 CCF41969.1 - 0.038 12.8 0.0 0.052 12.3 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain DAP3 PF10236.4 CCF41969.1 - 0.038 12.9 0.0 0.052 12.4 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DUF258 PF03193.11 CCF41969.1 - 0.041 13.0 0.0 0.041 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_5 PF07728.9 CCF41969.1 - 0.055 13.1 0.0 0.076 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) GBP PF02263.14 CCF41969.1 - 0.08 11.9 0.0 0.084 11.9 0.0 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain DUF815 PF05673.8 CCF41969.1 - 0.11 11.3 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_30 PF13604.1 CCF41969.1 - 0.12 11.9 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.15 CCF41969.1 - 0.14 11.8 0.0 0.17 11.5 0.0 1.1 1 0 0 1 1 1 0 Adenylylsulphate kinase DAO PF01266.19 CCF41970.1 - 7.2e-12 44.8 0.0 9.4e-12 44.4 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase HEM4 PF02602.10 CCF41970.1 - 0.052 12.7 0.0 0.085 12.0 0.0 1.2 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD NAD_binding_8 PF13450.1 CCF41970.1 - 0.15 12.1 0.0 0.37 10.8 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Cu-oxidase_3 PF07732.10 CCF41971.1 - 4e-42 142.6 4.4 6.5e-42 141.9 0.1 3.1 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 CCF41971.1 - 4.7e-32 110.3 3.5 3.2e-26 91.4 0.2 3.9 4 0 0 4 4 4 3 Multicopper oxidase Cu-oxidase PF00394.17 CCF41971.1 - 7e-16 58.5 0.0 1.1e-14 54.7 0.0 2.5 2 1 0 2 2 2 1 Multicopper oxidase Aldedh PF00171.17 CCF41972.1 - 2.2e-112 375.7 0.0 2.7e-112 375.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family zf-H2C2_2 PF13465.1 CCF41975.1 - 2.2e-10 40.2 18.7 3.5e-06 27.0 2.4 4.1 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.1 CCF41975.1 - 1.7e-06 27.9 12.0 0.0032 17.6 0.8 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF41975.1 - 2.5e-06 27.4 19.0 0.0011 19.1 2.9 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type DUF2225 PF09986.4 CCF41975.1 - 0.26 10.7 0.7 0.54 9.6 0.5 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-C2H2_6 PF13912.1 CCF41975.1 - 0.51 10.3 3.8 3.2 7.7 0.2 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Amino_oxidase PF01593.19 CCF41976.1 - 5.1e-48 164.2 0.2 1.5e-47 162.6 0.2 1.7 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 CCF41976.1 - 5.1e-14 52.0 0.2 2.1e-12 46.8 0.1 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF41976.1 - 3.3e-10 39.4 0.4 2.3e-08 33.3 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 CCF41976.1 - 6.4e-09 35.3 0.9 1.2e-08 34.5 0.6 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 CCF41976.1 - 8.8e-08 31.0 0.2 6.4e-06 24.8 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.19 CCF41976.1 - 5.1e-07 28.8 0.7 9.9e-07 27.9 0.5 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 CCF41976.1 - 1.5e-05 24.9 0.0 0.0014 18.5 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF41976.1 - 1.8e-05 24.9 0.1 0.008 16.2 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CCF41976.1 - 2e-05 23.6 0.6 0.00018 20.4 0.1 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox PF00070.22 CCF41976.1 - 3.5e-05 24.1 2.4 0.00017 21.9 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF41976.1 - 0.0001 21.4 0.0 0.00019 20.6 0.0 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.1 CCF41976.1 - 0.16 11.7 1.0 23 4.7 0.0 2.9 3 0 0 3 3 3 0 FAD-NAD(P)-binding DUF2263 PF10021.4 CCF41978.1 - 4.1e-25 88.5 0.1 1.1e-24 87.1 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2263) BCS1_N PF08740.6 CCF41979.1 - 1.1e-13 51.2 0.0 1.6e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 CCF41979.1 - 5.5e-13 49.2 0.0 9.2e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Miro PF08477.8 CCF41979.1 - 0.017 15.6 0.0 0.032 14.7 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein VirE PF05272.6 CCF41979.1 - 0.14 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Virulence-associated protein E Dynamin_N PF00350.18 CCF41979.1 - 0.14 11.9 0.1 0.32 10.7 0.0 1.5 2 0 0 2 2 2 0 Dynamin family Pkinase PF00069.20 CCF41980.1 - 2.8e-12 46.3 0.0 3.2e-11 42.8 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF41980.1 - 0.00032 19.8 0.0 0.00044 19.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Zn_ribbon_2 PF12674.2 CCF41981.1 - 0.016 15.5 0.9 0.42 10.9 0.0 2.5 2 0 0 2 2 2 0 Putative zinc ribbon domain DivIC PF04977.10 CCF41981.1 - 0.02 14.3 4.4 0.087 12.3 1.3 2.1 2 0 0 2 2 2 0 Septum formation initiator APG6 PF04111.7 CCF41981.1 - 0.078 12.0 0.6 0.11 11.4 0.4 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 zf-CCHC_4 PF14392.1 CCF41981.1 - 2.6 7.7 5.1 8.4 6.1 0.3 2.3 2 0 0 2 2 2 0 Zinc knuckle C1_2 PF03107.11 CCF41981.1 - 4.4 7.4 5.9 16 5.6 0.9 2.3 2 0 0 2 2 2 0 C1 domain Ribonuc_L-PSP PF01042.16 CCF41982.1 - 6.3e-17 61.4 0.0 9.5e-17 60.8 0.0 1.2 1 0 0 1 1 1 1 Endoribonuclease L-PSP HD PF01966.17 CCF41982.1 - 7e-05 22.8 0.1 0.00018 21.5 0.1 1.7 1 0 0 1 1 1 1 HD domain RVT_2 PF07727.9 CCF41983.1 - 3.4e-09 36.0 0.0 5.7e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 CCF41983.1 - 3.4e-08 33.6 0.1 9.3e-08 32.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.1 CCF41983.1 - 6.1e-05 22.5 1.8 0.00017 21.1 1.2 1.7 1 0 0 1 1 1 1 GAG-pre-integrase domain LigB PF02900.13 CCF41984.1 - 5.5e-49 166.5 1.2 6.6e-49 166.3 0.9 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase BORA_N PF15280.1 CCF41985.1 - 0.0058 16.0 0.1 0.0072 15.6 0.1 1.1 1 0 0 1 1 1 1 Protein aurora borealis N-terminus p47_phox_C PF08944.6 CCF41986.1 - 0.015 15.4 3.6 0.038 14.1 2.5 1.7 1 0 0 1 1 1 0 NADPH oxidase subunit p47Phox, C terminal domain p450 PF00067.17 CCF41988.1 - 2.7e-23 82.2 0.0 3.9e-23 81.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 eIF_4EBP PF05456.6 CCF41988.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Cys_Met_Meta_PP PF01053.15 CCF41989.1 - 1.9e-10 39.6 0.0 2.1e-10 39.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Filament_head PF04732.9 CCF41990.1 - 0.17 12.5 0.7 0.17 12.5 0.5 1.8 2 0 0 2 2 2 0 Intermediate filament head (DNA binding) region ATP-grasp_2 PF08442.5 CCF41991.1 - 9e-79 263.5 1.0 9e-79 263.5 0.7 1.7 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.14 CCF41991.1 - 5.1e-27 94.3 0.5 1e-26 93.3 0.3 1.5 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.1 CCF41991.1 - 1.9e-07 30.5 0.1 4.5e-07 29.3 0.1 1.7 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.14 CCF41991.1 - 0.0012 18.4 3.4 0.027 14.0 0.2 2.7 2 1 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_4 PF13535.1 CCF41991.1 - 0.0024 17.6 0.0 0.0042 16.8 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Peripla_BP_2 PF01497.13 CCF41991.1 - 0.024 13.7 0.4 0.043 12.9 0.3 1.4 1 0 0 1 1 1 0 Periplasmic binding protein ABC2_membrane PF01061.19 CCF41992.1 - 2.6e-93 311.0 47.2 8e-51 172.1 14.0 2.3 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.22 CCF41992.1 - 2.9e-39 134.4 0.0 2.7e-18 66.5 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.7 CCF41992.1 - 1.7e-28 98.2 5.2 8.8e-27 92.7 0.0 3.3 3 0 0 3 3 3 1 CDR ABC transporter ABC2_membrane_3 PF12698.2 CCF41992.1 - 1.5e-11 43.9 31.7 3.3e-06 26.3 4.6 2.4 2 0 0 2 2 2 2 ABC-2 family transporter protein ABC_trans_N PF14510.1 CCF41992.1 - 1.5e-07 31.4 0.1 4.8e-07 29.7 0.1 1.9 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_25 PF13481.1 CCF41992.1 - 2.8e-06 26.8 0.0 0.0037 16.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 CCF41992.1 - 6.4e-05 22.1 0.0 0.0077 15.4 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 CCF41992.1 - 6.4e-05 23.0 0.2 0.025 14.5 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 CCF41992.1 - 8.1e-05 22.7 0.0 0.057 13.5 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.1 CCF41992.1 - 0.00021 21.2 1.0 0.38 10.7 0.2 2.4 2 0 0 2 2 2 2 AAA domain cobW PF02492.14 CCF41992.1 - 0.00041 19.8 0.5 0.33 10.3 0.1 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 CCF41992.1 - 0.00085 19.6 0.0 2.2 8.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 CCF41992.1 - 0.0009 18.7 0.2 0.077 12.5 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_33 PF13671.1 CCF41992.1 - 0.0017 18.2 0.1 1.1 9.1 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_19 PF13245.1 CCF41992.1 - 0.0018 18.0 0.2 0.52 10.0 0.0 2.6 2 0 0 2 2 2 1 Part of AAA domain AAA_17 PF13207.1 CCF41992.1 - 0.0049 17.6 0.0 1.3 9.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.4 CCF41992.1 - 0.023 14.1 0.5 1.5 8.2 0.1 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation T2SE PF00437.15 CCF41992.1 - 0.028 13.3 0.1 0.34 9.7 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_21 PF13304.1 CCF41992.1 - 0.056 13.4 0.0 0.81 9.5 0.0 2.7 3 0 0 3 3 3 0 AAA domain NACHT PF05729.7 CCF41992.1 - 0.064 12.9 0.7 3.8 7.1 0.2 2.4 2 0 0 2 2 2 0 NACHT domain Arch_ATPase PF01637.13 CCF41992.1 - 0.1 12.2 0.0 12 5.5 0.0 2.3 2 0 0 2 2 2 0 Archaeal ATPase MMR_HSR1 PF01926.18 CCF41992.1 - 0.16 11.9 0.0 16 5.4 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase RuvB_N PF05496.7 CCF41992.1 - 0.21 10.5 0.1 3.3 6.6 0.0 2.1 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus Fungal_trans PF04082.13 CCF41993.1 - 1.8e-14 53.2 0.3 2.9e-14 52.5 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41993.1 - 1.5e-08 34.4 11.0 2.7e-08 33.5 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lip_A_acyltrans PF03279.8 CCF41993.1 - 0.11 11.3 0.0 0.19 10.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial lipid A biosynthesis acyltransferase Fungal_trans_2 PF11951.3 CCF41994.1 - 4e-42 144.1 0.0 5e-42 143.8 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF41994.1 - 5.1e-07 29.5 12.6 8.6e-07 28.7 8.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain U79_P34 PF03064.11 CCF41996.1 - 0.016 14.7 17.8 0.022 14.3 12.4 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Baculo_PP31 PF05311.6 CCF41996.1 - 0.025 13.8 4.7 0.033 13.4 3.3 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF2229 PF09989.4 CCF41996.1 - 0.21 11.0 4.2 0.26 10.7 2.9 1.3 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) GAGA_bind PF06217.7 CCF41996.1 - 0.21 11.5 8.2 0.24 11.3 5.7 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family TFIIF_alpha PF05793.7 CCF41996.1 - 0.23 9.7 23.7 0.26 9.6 16.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RR_TM4-6 PF06459.7 CCF41996.1 - 0.56 10.0 16.9 0.65 9.8 11.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RNase_H2-Ydr279 PF09468.5 CCF41996.1 - 0.57 9.3 12.1 0.71 9.0 8.4 1.2 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) DUF1510 PF07423.6 CCF41996.1 - 0.68 9.2 21.4 0.86 8.9 14.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) NARP1 PF12569.3 CCF41996.1 - 0.78 8.4 22.6 0.93 8.1 15.6 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Pox_Ag35 PF03286.9 CCF41996.1 - 0.79 9.2 15.2 0.92 8.9 10.5 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Rtf2 PF04641.7 CCF41996.1 - 0.86 8.7 16.8 1 8.5 11.6 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Zip PF02535.17 CCF41996.1 - 0.99 8.3 3.2 0.96 8.3 2.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SelP_N PF04592.9 CCF41996.1 - 1.1 8.6 5.3 1.3 8.3 3.6 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF3807 PF12720.2 CCF41996.1 - 1.3 9.1 20.1 1.7 8.7 14.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Borrelia_P83 PF05262.6 CCF41996.1 - 1.5 6.9 23.6 1.7 6.7 16.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DDHD PF02862.12 CCF41996.1 - 1.8 8.3 7.8 2 8.1 5.4 1.3 1 0 0 1 1 1 0 DDHD domain Tim54 PF11711.3 CCF41996.1 - 2.3 6.7 14.8 3 6.3 10.3 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Nop14 PF04147.7 CCF41996.1 - 2.8 5.7 22.3 3 5.6 15.5 1.0 1 0 0 1 1 1 0 Nop14-like family BTV_NS2 PF04514.7 CCF41996.1 - 3.6 6.3 15.1 3.9 6.2 10.5 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Vfa1 PF08432.5 CCF41996.1 - 3.9 7.4 28.4 6 6.8 19.7 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Hid1 PF12722.2 CCF41996.1 - 6 4.4 7.9 6.3 4.3 5.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC73 PF05179.9 CCF41996.1 - 6.1 6.1 10.5 7 5.9 6.6 1.6 2 0 0 2 2 2 0 RNA pol II accessory factor, Cdc73 family Herpes_DNAp_acc PF04929.7 CCF41996.1 - 6.7 5.5 8.1 7.9 5.3 5.6 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor APG6 PF04111.7 CCF41996.1 - 7.1 5.5 13.7 8.2 5.3 9.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Ribosomal_60s PF00428.14 CCF41997.1 - 3.5 8.0 10.9 5.3 7.5 7.6 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein MFS_1 PF07690.11 CCF42000.1 - 3.2e-37 128.0 46.6 3.2e-37 128.0 32.3 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF1673 PF07895.6 CCF42000.1 - 1.5 8.3 4.4 2.6 7.4 3.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) Ketoacyl-synt_C PF02801.17 CCF42001.1 - 3.5e-14 52.6 0.0 5.8e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Sugar_tr PF00083.19 CCF42002.1 - 5.7e-12 44.9 0.1 7.1e-12 44.6 0.1 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF42002.1 - 1.7e-11 43.4 0.3 4.6e-11 42.0 0.1 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF42002.1 - 0.0003 19.1 0.4 0.00041 18.6 0.3 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PhoQ_Sensor PF08918.5 CCF42002.1 - 0.023 14.2 0.0 0.038 13.4 0.0 1.3 1 0 0 1 1 1 0 PhoQ Sensor SH3_6 PF12913.2 CCF42002.1 - 0.075 12.2 0.1 0.19 10.9 0.1 1.7 1 0 0 1 1 1 0 SH3 domain of the SH3b1 type Claudin_2 PF13903.1 CCF42002.1 - 9.3 5.8 12.5 1.4e+02 2.0 0.0 3.9 3 1 1 4 4 4 0 PMP-22/EMP/MP20/Claudin tight junction MFS_1 PF07690.11 CCF42003.1 - 1.4e-40 139.1 27.1 2.1e-40 138.5 18.8 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF42003.1 - 9.4e-09 34.3 7.9 9.4e-09 34.3 5.4 2.2 3 1 1 4 4 4 1 Sugar (and other) transporter TRI12 PF06609.8 CCF42003.1 - 0.00014 20.2 5.1 0.00014 20.2 3.5 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) PAGK PF15284.1 CCF42003.1 - 0.051 13.3 0.7 0.72 9.6 0.0 3.0 4 0 0 4 4 4 0 Phage-encoded virulence factor HEAT PF02985.17 CCF42004.1 - 1.5e-36 121.1 13.6 0.0022 17.9 0.1 11.2 12 0 0 12 12 12 9 HEAT repeat HEAT_2 PF13646.1 CCF42004.1 - 2e-26 92.0 4.3 1.6e-08 34.6 0.0 6.0 2 2 4 6 6 6 6 HEAT repeats Vac14_Fab1_bd PF12755.2 CCF42004.1 - 1.4e-09 38.1 3.9 0.031 14.6 0.0 6.4 3 1 2 7 7 7 3 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 CCF42004.1 - 4.8e-09 36.4 9.4 0.0067 16.8 0.0 6.8 6 1 1 7 7 7 2 HEAT-like repeat Adaptin_N PF01602.15 CCF42004.1 - 1.6e-05 23.4 8.9 0.0029 15.9 0.1 4.2 1 1 1 3 3 3 2 Adaptin N terminal region DUF2435 PF10363.4 CCF42004.1 - 6.8e-05 22.6 4.7 0.069 13.0 0.1 4.6 4 1 1 5 5 5 1 Protein of unknown function (DUF2435) CLASP_N PF12348.3 CCF42004.1 - 0.00091 18.6 2.5 0.73 9.1 0.1 4.4 3 2 1 4 4 4 1 CLASP N terminal Cnd3 PF12719.2 CCF42004.1 - 0.0029 16.6 0.3 0.023 13.7 0.1 2.4 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain RIX1 PF08167.7 CCF42004.1 - 0.004 16.8 0.3 0.34 10.5 0.0 3.7 3 1 1 4 4 4 1 rRNA processing/ribosome biogenesis Cnd1 PF12717.2 CCF42004.1 - 0.021 14.6 5.8 7.6 6.3 0.0 5.0 2 1 3 6 6 6 0 non-SMC mitotic condensation complex subunit 1 Arm PF00514.18 CCF42004.1 - 0.025 14.3 4.0 11 6.0 0.0 5.0 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat Proteasom_PSMB PF10508.4 CCF42004.1 - 0.19 9.9 6.0 0.35 9.0 0.1 2.9 2 1 0 3 3 3 0 Proteasome non-ATPase 26S subunit Calreticulin PF00262.13 CCF42005.1 - 2.3e-115 385.1 23.5 2.3e-115 385.1 16.3 1.5 2 0 0 2 2 2 1 Calreticulin family Aldedh PF00171.17 CCF42006.1 - 1.1e-56 192.1 0.2 1.4e-56 191.7 0.1 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family p450 PF00067.17 CCF42007.1 - 1.3e-52 178.8 0.0 1.6e-52 178.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 LicD PF04991.8 CCF42010.1 - 6.5e-37 127.6 8.9 1.5e-35 123.1 6.2 2.1 1 1 0 1 1 1 1 LicD family WLM PF08325.5 CCF42011.1 - 8.7e-45 152.8 0.3 1.6e-44 152.0 0.0 1.5 1 1 1 2 2 2 1 WLM domain DUF45 PF01863.12 CCF42011.1 - 3.5e-05 23.7 0.6 3.5e-05 23.7 0.4 1.5 2 0 0 2 2 2 1 Protein of unknown function DUF45 SprT-like PF10263.4 CCF42011.1 - 0.012 15.2 0.3 0.02 14.5 0.2 1.4 1 0 0 1 1 1 0 SprT-like family Peptidase_MA_2 PF13485.1 CCF42011.1 - 0.045 13.7 0.2 0.097 12.7 0.1 1.5 1 0 0 1 1 1 0 Peptidase MA superfamily Reprolysin_5 PF13688.1 CCF42011.1 - 0.047 13.6 0.8 0.094 12.6 0.2 1.6 1 1 0 1 1 1 0 Metallo-peptidase family M12 ubiquitin PF00240.18 CCF42011.1 - 0.078 12.3 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family ER_lumen_recept PF00810.13 CCF42012.1 - 1.5e-53 181.2 10.0 2.4e-53 180.5 6.9 1.3 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.9 CCF42012.1 - 0.069 12.7 8.5 1.3 8.5 0.7 3.2 3 0 0 3 3 3 0 PQ loop repeat BMF PF15185.1 CCF42013.1 - 0.11 11.7 0.4 0.19 10.9 0.0 1.6 2 0 0 2 2 2 0 Bcl-2-modifying factor, apoptosis Ribosomal_60s PF00428.14 CCF42014.1 - 4.6 7.7 8.9 7.6 7.0 0.3 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein Pex26 PF07163.7 CCF42018.1 - 0.14 11.0 0.2 0.18 10.6 0.1 1.1 1 0 0 1 1 1 0 Pex26 protein Fungal_trans PF04082.13 CCF42019.1 - 1.1e-21 76.9 0.0 1.9e-21 76.1 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF42019.1 - 4.1e-09 36.1 11.0 8.9e-09 35.1 7.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HalX PF08663.5 CCF42019.1 - 0.036 14.0 0.7 0.52 10.3 0.3 2.5 2 0 0 2 2 2 0 HalX domain Aa_trans PF01490.13 CCF42020.1 - 1.2e-30 106.3 34.9 1.4e-30 106.1 24.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.1 CCF42020.1 - 0.0011 17.5 44.4 0.068 11.7 30.8 2.7 1 1 0 1 1 1 1 Amino acid permease p450 PF00067.17 CCF42021.1 - 4.7e-65 219.9 0.0 5.4e-65 219.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Thioesterase PF00975.15 CCF42023.1 - 1.9e-25 90.4 0.0 3e-25 89.7 0.0 1.3 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.2 CCF42023.1 - 2.9e-07 30.5 0.5 4.1e-07 30.1 0.3 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF42023.1 - 0.0041 16.8 0.0 0.0057 16.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Sugar_tr PF00083.19 CCF42025.1 - 4.4e-34 117.8 12.0 5e-34 117.6 8.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF42025.1 - 3.5e-07 29.2 19.3 4.1e-07 29.0 12.6 1.5 1 1 0 2 2 2 1 Major Facilitator Superfamily ABC2_membrane_5 PF13346.1 CCF42025.1 - 2.5 7.3 12.6 0.043 13.0 2.0 2.0 1 1 1 2 2 2 0 ABC-2 family transporter protein GtrA PF04138.9 CCF42025.1 - 4.5 7.2 14.6 0.2 11.5 4.6 2.3 1 1 1 2 2 2 0 GtrA-like protein Fungal_trans PF04082.13 CCF42026.1 - 2.7e-09 36.2 0.0 4.5e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain AMP-binding PF00501.23 CCF42027.1 - 1e-58 198.7 1.7 8.4e-44 149.6 0.0 2.8 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.1 CCF42027.1 - 6.4e-12 46.2 0.8 1.6e-11 45.0 0.2 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain IF4E PF01652.13 CCF42028.1 - 8.4e-52 175.0 0.0 9.6e-52 174.8 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E APH PF01636.18 CCF42030.1 - 1.5e-13 51.0 0.0 2.4e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 CCF42030.1 - 2.6e-05 23.5 0.0 4.2e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.6 CCF42030.1 - 0.022 13.4 0.0 0.032 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Zn_clus PF00172.13 CCF42031.1 - 9.7e-07 28.6 7.0 1.9e-06 27.6 4.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF42031.1 - 0.0042 15.7 1.6 0.0053 15.3 0.5 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF2797 PF10977.3 CCF42031.1 - 0.36 10.4 2.7 0.59 9.7 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) Pico_P2B PF01552.12 CCF42032.1 - 0.021 14.9 0.0 0.029 14.5 0.0 1.2 1 0 0 1 1 1 0 Picornavirus 2B protein Vac14_Fig4_bd PF11916.3 CCF42032.1 - 0.095 11.8 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Vacuolar protein 14 C-terminal Fig4p binding Methyltransf_2 PF00891.13 CCF42033.1 - 9e-26 90.5 0.0 1.1e-25 90.2 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase AMP-binding PF00501.23 CCF42034.1 - 2.9e-90 302.6 0.0 3.8e-90 302.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.15 CCF42034.1 - 7.4e-60 202.3 0.0 1.1e-59 201.7 0.0 1.2 1 0 0 1 1 1 1 Condensation domain HxxPF_rpt PF13745.1 CCF42034.1 - 7.6e-23 80.6 0.1 2.4e-22 79.0 0.0 2.0 1 0 0 1 1 1 1 HxxPF-repeated domain PP-binding PF00550.20 CCF42034.1 - 6.6e-13 48.7 0.2 2.1e-12 47.1 0.0 1.9 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.1 CCF42034.1 - 1.6e-08 35.3 1.1 0.00041 21.2 0.0 3.1 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain DDE_1 PF03184.14 CCF42035.1 - 1e-24 86.8 0.0 1.2e-24 86.6 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Vps26 PF03643.10 CCF42037.1 - 9.4e-131 434.5 0.8 1.1e-130 434.3 0.6 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.24 CCF42037.1 - 6.7e-05 22.7 0.0 0.2 11.5 0.0 3.4 1 1 2 3 3 3 2 Arrestin (or S-antigen), N-terminal domain DUF432 PF04254.8 CCF42037.1 - 0.076 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF432) p450 PF00067.17 CCF42038.1 - 6.1e-34 117.3 0.0 1.4e-33 116.1 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 Mre11_DNA_bind PF04152.9 CCF42039.1 - 1.5e-54 184.5 0.3 1.5e-54 184.5 0.2 2.1 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.23 CCF42039.1 - 0.0087 15.4 0.5 0.014 14.8 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Mucin PF01456.12 CCF42040.1 - 0.47 10.2 21.3 0.67 9.7 14.8 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Radical_SAM PF04055.16 CCF42041.1 - 0.081 13.1 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Radical SAM superfamily Acyl_transf_3 PF01757.17 CCF42042.1 - 1.1e-10 40.9 1.8 2.6e-10 39.6 0.5 1.8 2 0 0 2 2 2 1 Acyltransferase family DUF1275 PF06912.6 CCF42042.1 - 0.062 12.4 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1275) OpgC_C PF10129.4 CCF42042.1 - 0.078 11.6 0.0 0.21 10.2 0.0 1.7 1 1 1 2 2 2 0 OpgC protein GFO_IDH_MocA PF01408.17 CCF42044.1 - 2.5e-15 57.0 0.0 2.7e-15 56.9 0.0 1.1 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold COesterase PF00135.23 CCF42045.1 - 2.9e-90 303.5 0.0 3.8e-90 303.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF42045.1 - 0.00047 19.7 0.2 0.0025 17.4 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Glyco_hydro_12 PF01670.11 CCF42046.1 - 4.5e-15 55.7 7.5 1.7e-13 50.6 1.5 2.9 2 1 1 3 3 3 2 Glycosyl hydrolase family 12 PseudoU_synth_1 PF01416.15 CCF42047.1 - 2.1e-24 85.9 0.1 5.2e-11 42.8 0.0 2.9 3 1 0 3 3 3 2 tRNA pseudouridine synthase MCPVI PF02993.9 CCF42047.1 - 0.014 15.5 4.9 0.03 14.4 3.4 1.4 1 0 0 1 1 1 0 Minor capsid protein VI Tannase PF07519.6 CCF42048.1 - 7.2e-92 308.5 0.8 8.6e-92 308.2 0.6 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_6 PF12697.2 CCF42048.1 - 8.8e-09 35.5 0.0 4.4e-08 33.2 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF42048.1 - 1.6e-05 24.2 0.0 0.078 12.1 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 CCF42048.1 - 0.0053 16.3 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF42048.1 - 0.0082 15.8 0.9 0.38 10.4 0.3 2.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family ADH_zinc_N_2 PF13602.1 CCF42049.1 - 4.3e-24 85.8 0.0 8.6e-24 84.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 CCF42049.1 - 8.4e-18 64.1 0.2 2.1e-17 62.8 0.2 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF42049.1 - 0.00076 19.2 0.0 0.0088 15.7 0.0 2.3 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain DUF1399 PF07173.7 CCF42050.1 - 3.8e-10 40.1 1.9 0.0055 16.9 0.2 3.5 3 1 1 4 4 4 3 Protein of unknown function (DUF1399) MFS_1 PF07690.11 CCF42053.1 - 4.4e-05 22.3 5.2 5.5e-05 22.0 3.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Glyco_hydro_3 PF00933.16 CCF42054.1 - 7.1e-54 182.8 0.5 1.1e-53 182.2 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 CCF42054.1 - 0.0015 18.0 0.0 0.0027 17.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain PfkB PF00294.19 CCF42055.1 - 7.1e-17 61.4 0.0 2.3e-16 59.8 0.0 1.7 1 1 0 1 1 1 1 pfkB family carbohydrate kinase FA_hydroxylase PF04116.8 CCF42057.1 - 3.4e-12 46.7 7.8 3.4e-12 46.7 5.4 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily DAO PF01266.19 CCF42059.1 - 6.3e-07 28.6 0.0 9.8e-07 27.9 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase adh_short_C2 PF13561.1 CCF42060.1 - 2.5e-24 86.3 0.0 2.9e-24 86.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF42060.1 - 1.5e-14 54.3 0.1 1.9e-14 53.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF42060.1 - 3.4e-07 30.1 0.1 4.6e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF42060.1 - 0.017 14.5 0.3 0.057 12.8 0.2 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Acetate_kinase PF00871.12 CCF42060.1 - 0.063 11.8 0.0 0.084 11.3 0.0 1.2 1 0 0 1 1 1 0 Acetokinase family DUF1682 PF07946.9 CCF42062.1 - 6.5e-106 353.8 0.1 7.5e-106 353.5 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF2140 PF09911.4 CCF42062.1 - 0.39 9.8 0.0 0.39 9.8 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) DUF77 PF01910.12 CCF42063.1 - 9.7e-15 54.0 0.1 1.2e-14 53.7 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function DUF77 Cyto_heme_lyase PF01265.12 CCF42066.1 - 2.2e-62 210.9 0.0 2.5e-62 210.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase ABC1 PF03109.11 CCF42067.1 - 1.2e-22 80.1 0.1 1.8e-22 79.5 0.1 1.3 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 CCF42067.1 - 4.8e-05 23.1 3.4 0.0041 16.8 0.0 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family Sec7_N PF12783.2 CCF42068.1 - 2.8e-38 130.9 1.1 1.9e-36 125.0 0.1 2.4 2 0 0 2 2 2 2 Guanine nucleotide exchange factor in Golgi transport N-terminal UQ_con PF00179.21 CCF42069.1 - 4.4e-17 61.8 0.0 4.7e-17 61.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 CCF42069.1 - 0.0034 17.2 0.0 0.0034 17.2 0.0 1.2 1 0 0 1 1 1 1 RWD domain Band_7 PF01145.20 CCF42070.1 - 1.1e-31 110.1 0.4 1.9e-31 109.3 0.3 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.1 CCF42070.1 - 0.034 13.6 0.0 0.06 12.8 0.0 1.5 1 0 0 1 1 1 0 SPFH domain-Band 7 family Zn_clus PF00172.13 CCF42073.1 - 7.8e-05 22.4 10.7 0.00013 21.8 7.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF42073.1 - 0.00028 19.8 0.1 0.00046 19.1 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain RecO_C PF02565.10 CCF42073.1 - 0.07 12.9 0.0 0.38 10.6 0.0 2.0 2 0 0 2 2 2 0 Recombination protein O C terminal Matrilin_ccoil PF10393.4 CCF42073.1 - 0.27 10.6 0.4 1.6 8.1 0.2 2.2 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin RhoGAP PF00620.22 CCF42074.1 - 1.5e-43 148.0 0.4 4.8e-43 146.3 0.2 1.9 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.24 CCF42074.1 - 1.7e-09 37.8 0.0 3.7e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 CCF42074.1 - 4.3e-07 30.1 0.0 1.3e-06 28.6 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.1 CCF42074.1 - 0.0077 16.2 0.1 0.15 12.1 0.0 2.4 2 0 0 2 2 2 1 Pleckstrin homology domain R3H-assoc PF13902.1 CCF42077.1 - 8.7e-21 74.2 1.4 1.4e-20 73.5 1.0 1.3 1 0 0 1 1 1 1 R3H-associated N-terminal domain AXE1 PF05448.7 CCF42078.1 - 0.11 10.9 0.0 0.17 10.3 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) CFEM PF05730.6 CCF42079.1 - 1e-12 47.6 9.8 1.8e-12 46.8 6.8 1.4 1 0 0 1 1 1 1 CFEM domain Sugar_tr PF00083.19 CCF42080.1 - 1.4e-19 70.0 23.4 2.8e-15 55.8 10.2 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter Transgly_assoc PF04226.8 CCF42080.1 - 0.22 11.6 0.3 0.22 11.6 0.2 4.2 3 2 1 4 4 4 0 Transglycosylase associated protein DUF2929 PF11151.3 CCF42080.1 - 0.91 9.6 8.7 0.2 11.7 0.3 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2929) ADH_N PF08240.7 CCF42081.1 - 9.1e-13 47.9 3.7 2.2e-12 46.6 0.2 2.6 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF42081.1 - 2.4e-06 27.0 0.6 5e-06 26.0 0.4 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TrkA_N PF02254.13 CCF42081.1 - 0.011 15.7 0.2 0.017 15.0 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain AlaDh_PNT_C PF01262.16 CCF42081.1 - 0.073 12.6 0.3 0.15 11.5 0.2 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Hexapep PF00132.19 CCF42081.1 - 0.1 12.1 0.5 0.38 10.3 0.1 2.1 2 0 0 2 2 2 0 Bacterial transferase hexapeptide (six repeats) 3HCDH_N PF02737.13 CCF42081.1 - 0.15 11.7 0.8 0.38 10.3 0.5 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Reprolysin_5 PF13688.1 CCF42082.1 - 2.7e-06 27.4 0.6 5e-06 26.5 0.4 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.1 CCF42082.1 - 1.1e-05 25.1 0.5 1.7e-05 24.4 0.3 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Pep_M12B_propep PF01562.14 CCF42082.1 - 0.019 14.7 0.3 0.04 13.7 0.1 1.6 2 0 0 2 2 2 0 Reprolysin family propeptide AA_permease PF00324.16 CCF42083.1 - 8.6e-98 327.7 36.3 9.8e-98 327.5 25.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF42083.1 - 7.8e-29 100.4 42.9 9.2e-29 100.2 29.8 1.1 1 0 0 1 1 1 1 Amino acid permease FKBP_C PF00254.23 CCF42084.1 - 3.7e-28 97.3 0.1 4.6e-28 97.0 0.1 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF3328 PF11807.3 CCF42085.1 - 2.3e-37 128.8 5.7 3.2e-37 128.3 3.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) adh_short_C2 PF13561.1 CCF42086.1 - 1.2e-10 41.6 0.1 1.3e-10 41.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF4232 PF14016.1 CCF42086.1 - 0.2 11.3 1.1 0.22 11.1 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4232) Fungal_trans_2 PF11951.3 CCF42087.1 - 2.4e-10 39.5 0.1 2.8e-10 39.3 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans PF04082.13 CCF42087.1 - 0.087 11.6 0.3 0.13 11.1 0.2 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain HEAT_EZ PF13513.1 CCF42089.1 - 1.7e-29 101.4 10.5 3.3e-13 49.6 0.0 10.7 9 3 4 13 13 12 7 HEAT-like repeat HEAT PF02985.17 CCF42089.1 - 2.6e-28 95.5 10.8 2.3e-05 24.0 0.0 9.2 9 0 0 9 9 9 6 HEAT repeat HEAT_2 PF13646.1 CCF42089.1 - 5.6e-26 90.6 0.1 2.8e-08 33.9 0.0 6.9 3 3 5 8 8 8 7 HEAT repeats Vac14_Fab1_bd PF12755.2 CCF42089.1 - 5.2e-09 36.3 0.0 0.0011 19.2 0.0 5.5 4 2 3 7 7 7 1 Vacuolar 14 Fab1-binding region MMS19_C PF12460.3 CCF42089.1 - 8.6e-09 34.6 2.1 0.011 14.4 0.0 4.6 5 0 0 5 5 5 3 RNAPII transcription regulator C-terminal Cnd1 PF12717.2 CCF42089.1 - 9.6e-07 28.8 1.0 0.26 11.0 0.0 5.0 4 2 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.3 CCF42089.1 - 2e-05 24.0 0.0 8.3 5.6 0.0 6.0 4 2 2 6 6 6 1 CLASP N terminal HEAT_PBS PF03130.11 CCF42089.1 - 7.2e-05 22.8 2.8 6.5 7.5 0.0 4.8 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat Adaptin_N PF01602.15 CCF42089.1 - 0.00025 19.5 0.1 0.98 7.6 0.0 3.2 3 1 0 3 3 3 2 Adaptin N terminal region Arm PF00514.18 CCF42089.1 - 0.0016 18.2 4.1 4.1 7.3 0.0 5.3 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat DUF3437 PF11919.3 CCF42089.1 - 0.003 17.2 0.2 0.21 11.3 0.0 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) RIX1 PF08167.7 CCF42089.1 - 0.011 15.3 0.3 1.7 8.3 0.0 4.1 6 0 0 6 6 6 0 rRNA processing/ribosome biogenesis ADH_N PF08240.7 CCF42090.1 - 3.4e-18 65.3 0.2 4.4e-18 65.0 0.1 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain tRNA_SAD PF07973.9 CCF42091.1 - 7.7e-05 22.4 0.3 0.00017 21.3 0.2 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.14 CCF42091.1 - 0.0002 19.7 0.0 0.00024 19.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) GATase PF00117.23 CCF42092.1 - 4.2e-09 36.1 0.0 8.6e-09 35.1 0.0 1.5 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 CCF42092.1 - 4.3e-05 23.0 0.1 9.2e-05 21.9 0.0 1.6 1 1 0 1 1 1 1 Peptidase C26 AMP-binding PF00501.23 CCF42093.1 - 9.5e-119 396.4 0.0 3.2e-78 262.9 0.0 2.3 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.15 CCF42093.1 - 4.5e-51 173.4 0.2 1.5e-24 86.4 0.0 3.0 2 1 0 2 2 2 2 Condensation domain PP-binding PF00550.20 CCF42093.1 - 2.9e-22 78.6 0.1 1.8e-10 40.9 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.1 CCF42093.1 - 5.1e-13 49.7 0.0 7.5e-07 30.0 0.0 2.8 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain GH3 PF03321.8 CCF42093.1 - 0.01 14.4 0.0 2.8 6.3 0.0 2.3 2 0 0 2 2 2 0 GH3 auxin-responsive promoter Candida_ALS PF05792.8 CCF42094.1 - 1.7e-25 88.8 272.8 4.1e-07 30.0 8.9 18.3 17 2 0 17 17 17 9 Candida agglutinin-like (ALS) DUF2381 PF09544.5 CCF42094.1 - 0.034 13.2 0.1 0.92 8.5 0.0 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2381) Acyl-CoA_ox_N PF14749.1 CCF42095.1 - 0.09 13.0 0.2 1.6 9.0 0.0 2.0 2 0 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal CRIC_ras_sig PF10534.4 CCF42095.1 - 0.14 12.2 0.2 26 4.9 0.1 2.6 2 1 0 2 2 2 0 Connector enhancer of kinase suppressor of ras DUF4185 PF13810.1 CCF42096.1 - 2.1e-09 36.7 1.1 3.1e-09 36.1 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4185) p450 PF00067.17 CCF42101.1 - 2.1e-13 49.5 0.0 2.8e-13 49.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 ESSS PF10183.4 CCF42102.1 - 0.061 13.7 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Cupin_8 PF13621.1 CCF42103.1 - 1.4e-39 136.1 0.0 1.9e-39 135.6 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Kelch_4 PF13418.1 CCF42103.1 - 6.7e-08 32.1 8.3 6.2e-07 29.0 0.0 4.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_3 PF13415.1 CCF42103.1 - 2.4e-06 27.5 15.5 0.0012 18.9 0.0 5.5 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.1 CCF42103.1 - 6.7e-06 26.0 4.4 0.031 14.4 0.0 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.1 CCF42103.1 - 4.8e-05 23.1 0.1 0.22 11.5 0.0 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.20 CCF42103.1 - 0.00011 21.6 0.0 0.022 14.2 0.0 3.3 3 0 0 3 3 3 1 Kelch motif Cupin_4 PF08007.7 CCF42103.1 - 0.00099 18.4 0.0 0.0027 16.9 0.0 1.7 2 0 0 2 2 2 1 Cupin superfamily protein Kelch_2 PF07646.10 CCF42103.1 - 0.45 10.3 3.9 10 6.0 0.0 3.2 3 0 0 3 3 3 0 Kelch motif MFS_1 PF07690.11 CCF42104.1 - 3.8e-13 48.8 13.9 4.4e-13 48.6 9.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF897 PF05982.7 CCF42104.1 - 0.061 12.1 9.7 0.027 13.2 1.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF897) MFS_2 PF13347.1 CCF42104.1 - 0.14 10.5 12.3 1.3 7.2 8.4 2.0 1 1 0 1 1 1 0 MFS/sugar transport protein ATG22 PF11700.3 CCF42104.1 - 0.44 8.9 11.7 0.97 7.8 8.1 1.5 1 1 0 1 1 1 0 Vacuole effluxer Atg22 like Sugar_tr PF00083.19 CCF42104.1 - 1 7.8 9.4 1.3 7.5 6.5 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter Pkinase PF00069.20 CCF42106.1 - 7e-53 179.4 0.0 1.6e-52 178.2 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF42106.1 - 1.4e-23 83.2 0.0 3.3e-23 82.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CCF42106.1 - 0.00051 19.8 0.1 0.00051 19.8 0.0 2.3 2 1 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 CCF42106.1 - 0.0032 16.8 0.2 0.011 15.1 0.1 1.7 1 1 0 1 1 1 1 RIO1 family DUF4430 PF14478.1 CCF42106.1 - 0.088 12.8 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4430) RRM_1 PF00076.17 CCF42108.1 - 0.0074 15.9 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PPR_2 PF13041.1 CCF42109.1 - 1.8e-24 85.4 0.9 1e-15 57.4 0.0 5.9 5 2 2 7 7 7 2 PPR repeat family PPR_3 PF13812.1 CCF42109.1 - 1e-15 56.6 9.9 0.019 15.2 0.0 9.7 10 0 0 10 10 10 3 Pentatricopeptide repeat domain PPR PF01535.15 CCF42109.1 - 1.1e-12 46.9 2.8 0.048 13.6 0.0 8.0 7 0 0 7 7 7 2 PPR repeat PPR_1 PF12854.2 CCF42109.1 - 4.9e-06 25.9 4.8 2.1 7.9 0.0 6.2 7 0 0 7 7 7 2 PPR repeat ATP13 PF12921.2 CCF42109.1 - 0.00022 20.5 0.0 0.00093 18.5 0.0 2.1 1 0 0 1 1 1 1 Mitochondrial ATPase expression ERAP1_C PF11838.3 CCF42109.1 - 0.0016 17.7 2.8 0.0053 16.0 0.3 2.7 3 0 0 3 3 3 1 ERAP1-like C-terminal domain TPR_14 PF13428.1 CCF42109.1 - 0.054 14.1 4.5 80 4.2 0.0 5.8 4 2 2 6 6 6 0 Tetratricopeptide repeat Clathrin PF00637.15 CCF42109.1 - 0.061 12.9 5.6 0.8 9.3 0.1 3.2 3 0 0 3 3 3 0 Region in Clathrin and VPS TPR_19 PF14559.1 CCF42109.1 - 0.12 12.7 3.8 0.92 9.8 0.0 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat EcsB PF05975.7 CCF42109.1 - 0.25 9.7 0.6 5.1 5.4 0.0 2.1 2 0 0 2 2 2 0 Bacterial ABC transporter protein EcsB PhaP_Bmeg PF09602.5 CCF42110.1 - 0.0045 16.8 0.0 0.0085 15.9 0.0 1.4 1 0 0 1 1 1 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Trypsin_2 PF13365.1 CCF42110.1 - 0.0086 16.0 0.0 0.026 14.5 0.0 1.8 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S3 PF00944.14 CCF42110.1 - 0.085 12.2 0.1 0.16 11.3 0.1 1.4 1 0 0 1 1 1 0 Alphavirus core protein Peptidase_S64 PF08192.6 CCF42110.1 - 0.13 10.5 0.0 0.71 8.1 0.0 2.0 1 1 0 1 1 1 0 Peptidase family S64 Med13_C PF06333.7 CCF42111.1 - 2.3e-103 345.9 0.0 3.1e-103 345.5 0.0 1.2 1 0 0 1 1 1 1 Mediator complex subunit 13 C-terminal AAA PF00004.24 CCF42112.1 - 3.6e-32 111.3 0.0 1.4e-30 106.1 0.0 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF42112.1 - 3.6e-06 27.0 0.2 1.2e-05 25.3 0.0 2.0 2 1 0 2 2 1 1 AAA ATPase domain AAA_14 PF13173.1 CCF42112.1 - 4.2e-06 26.6 0.0 8.8e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CCF42112.1 - 8.2e-06 25.9 1.3 0.00068 19.7 0.0 3.1 2 1 2 4 4 3 1 AAA domain RuvB_N PF05496.7 CCF42112.1 - 8.6e-06 24.9 0.0 2.7e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 CCF42112.1 - 1.4e-05 25.8 0.0 3.3e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 CCF42112.1 - 4.8e-05 23.1 0.1 0.00044 19.9 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 CCF42112.1 - 5.6e-05 23.1 0.0 0.00011 22.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.1 CCF42112.1 - 0.00039 20.3 0.0 0.00078 19.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 CCF42112.1 - 0.00065 18.8 0.0 0.0013 17.9 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin Mg_chelatase PF01078.16 CCF42112.1 - 0.0015 17.7 0.1 0.0032 16.6 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 CCF42112.1 - 0.0018 17.9 0.2 0.0082 15.8 0.1 2.1 1 1 0 1 1 1 1 Part of AAA domain RNA_helicase PF00910.17 CCF42112.1 - 0.0025 17.9 0.0 0.0083 16.2 0.0 1.9 2 0 0 2 2 1 1 RNA helicase AAA_25 PF13481.1 CCF42112.1 - 0.0034 16.8 0.6 0.13 11.6 0.1 2.6 1 1 1 3 3 3 1 AAA domain NACHT PF05729.7 CCF42112.1 - 0.0041 16.7 0.1 0.016 14.8 0.0 1.9 2 1 0 2 2 2 1 NACHT domain IstB_IS21 PF01695.12 CCF42112.1 - 0.0045 16.4 0.0 0.0082 15.5 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activ_2 PF14532.1 CCF42112.1 - 0.0052 16.8 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_28 PF13521.1 CCF42112.1 - 0.0077 16.2 0.1 0.022 14.7 0.0 1.9 2 0 0 2 2 1 1 AAA domain DUF815 PF05673.8 CCF42112.1 - 0.0085 15.0 0.0 0.016 14.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.1 CCF42112.1 - 0.0094 16.2 0.0 0.035 14.4 0.0 2.0 2 0 0 2 2 1 1 AAA domain Sigma54_activat PF00158.21 CCF42112.1 - 0.01 15.3 0.0 0.028 13.8 0.0 1.7 2 0 0 2 2 1 0 Sigma-54 interaction domain AAA_24 PF13479.1 CCF42112.1 - 0.017 14.7 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain TOMM6 PF15184.1 CCF42112.1 - 0.02 14.1 0.1 0.049 12.9 0.1 1.6 1 0 0 1 1 1 0 Mitochondrial import receptor subunit TOM6 homolog TIP49 PF06068.8 CCF42112.1 - 0.024 13.3 0.0 0.044 12.5 0.0 1.4 1 0 0 1 1 1 0 TIP49 C-terminus NB-ARC PF00931.17 CCF42112.1 - 0.027 13.3 0.0 0.055 12.3 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Arch_ATPase PF01637.13 CCF42112.1 - 0.027 14.1 0.0 0.12 12.0 0.0 1.9 1 1 1 2 2 2 0 Archaeal ATPase AAA_10 PF12846.2 CCF42112.1 - 0.039 13.3 0.3 2.3 7.5 0.0 2.8 3 0 0 3 3 3 0 AAA-like domain ABC_tran PF00005.22 CCF42112.1 - 0.064 13.5 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Guanylate_kin PF00625.16 CCF42112.1 - 0.065 12.6 0.0 0.38 10.1 0.0 2.2 2 1 0 2 2 2 0 Guanylate kinase Rad17 PF03215.10 CCF42112.1 - 0.087 11.4 0.0 0.13 10.9 0.0 1.3 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Viral_helicase1 PF01443.13 CCF42112.1 - 0.1 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Bac_DnaA PF00308.13 CCF42112.1 - 0.15 11.7 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein Hydantoinase_B PF02538.9 CCF42115.1 - 9.2e-53 179.2 7.5 1.1e-52 179.0 5.2 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Fic PF02661.13 CCF42116.1 - 7e-16 58.7 0.0 1.6e-15 57.5 0.0 1.7 1 0 0 1 1 1 1 Fic/DOC family PV-1 PF06637.6 CCF42116.1 - 0.16 10.4 0.0 0.26 9.8 0.0 1.2 1 0 0 1 1 1 0 PV-1 protein (PLVAP) NmrA PF05368.8 CCF42117.1 - 2.1e-13 50.1 0.0 2.7e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF42117.1 - 0.035 14.1 0.3 0.12 12.3 0.2 1.9 1 1 0 1 1 1 0 NADH(P)-binding FtsX PF02687.16 CCF42119.1 - 0.091 12.5 1.4 0.12 12.0 0.9 1.2 1 1 0 1 1 1 0 FtsX-like permease family Glyco_hydro_61 PF03443.9 CCF42122.1 - 8.8e-73 244.7 0.4 1.1e-72 244.4 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Peptidase_C14 PF00656.17 CCF42124.1 - 3.8e-51 174.1 0.0 4.6e-51 173.9 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Ndc80_HEC PF03801.8 CCF42124.1 - 0.084 12.3 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 HEC/Ndc80p family CDC45 PF02724.9 CCF42126.1 - 7.4e-171 569.3 0.0 9.9e-171 568.9 0.0 1.2 1 0 0 1 1 1 1 CDC45-like protein Metal_resist PF13801.1 CCF42126.1 - 0.055 13.4 1.2 0.1 12.6 0.2 1.9 2 0 0 2 2 2 0 Heavy-metal resistance Vfa1 PF08432.5 CCF42126.1 - 3.8 7.5 9.5 11 5.9 6.9 1.5 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Amidase PF01425.16 CCF42127.1 - 1.3e-60 205.5 0.2 1.4e-60 205.3 0.1 1.0 1 0 0 1 1 1 1 Amidase Transp_cyt_pur PF02133.10 CCF42128.1 - 7.7e-52 176.3 14.6 8.9e-52 176.0 10.1 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Bac_luciferase PF00296.15 CCF42129.1 - 0.14 11.2 0.4 0.16 11.0 0.3 1.0 1 0 0 1 1 1 0 Luciferase-like monooxygenase DHDPS PF00701.17 CCF42130.1 - 1.2e-38 132.3 0.0 1.6e-38 131.9 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family HTH_29 PF13551.1 CCF42130.1 - 0.038 14.1 0.0 0.59 10.2 0.0 2.6 3 0 0 3 3 3 0 Winged helix-turn helix CobU PF02283.11 CCF42131.1 - 0.44 9.9 2.7 0.96 8.8 1.9 1.5 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase DUF4163 PF13739.1 CCF42131.1 - 0.8 10.5 3.3 17 6.2 0.0 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4163) AFG1_ATPase PF03969.11 CCF42132.1 - 2.9e-54 184.2 0.1 2.1e-26 92.5 0.0 4.5 3 2 1 4 4 4 3 AFG1-like ATPase AAA_16 PF13191.1 CCF42132.1 - 1.4e-05 25.1 1.0 0.0077 16.2 0.0 3.3 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.9 CCF42132.1 - 0.00043 20.0 0.0 0.00098 18.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 CCF42132.1 - 0.0042 17.2 0.0 0.018 15.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain Bac_DnaA PF00308.13 CCF42132.1 - 0.012 15.2 0.0 0.19 11.3 0.0 2.4 2 0 0 2 2 2 0 Bacterial dnaA protein AAA PF00004.24 CCF42132.1 - 0.016 15.4 0.0 0.033 14.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 CCF42132.1 - 0.017 15.0 0.0 0.037 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 CCF42132.1 - 0.017 15.3 0.1 3.2 8.0 0.0 2.4 1 1 1 2 2 2 0 ABC transporter NACHT PF05729.7 CCF42132.1 - 0.025 14.2 0.1 0.17 11.5 0.1 2.2 2 1 0 2 2 2 0 NACHT domain KAP_NTPase PF07693.9 CCF42132.1 - 0.076 11.9 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain AAA_29 PF13555.1 CCF42132.1 - 0.12 11.9 0.0 0.29 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RTA1 PF04479.8 CCF42133.1 - 6.9e-14 51.8 0.9 6.9e-14 51.8 0.6 1.6 2 0 0 2 2 2 1 RTA1 like protein LHC PF00556.15 CCF42133.1 - 0.15 11.9 1.0 0.33 10.8 0.7 1.6 1 0 0 1 1 1 0 Antenna complex alpha/beta subunit Esterase_phd PF10503.4 CCF42136.1 - 6.9e-22 77.7 0.8 1.2e-21 76.9 0.5 1.3 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.16 CCF42136.1 - 3.7e-10 39.3 0.7 5.5e-10 38.8 0.5 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CCF42136.1 - 6.1e-05 22.7 0.1 0.00011 22.0 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF42136.1 - 0.0013 18.7 0.1 0.002 18.0 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF42136.1 - 0.0013 18.3 0.2 0.002 17.7 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 CCF42136.1 - 0.0058 15.3 1.5 0.016 13.9 0.1 1.9 2 0 0 2 2 2 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF42136.1 - 0.036 13.6 0.0 0.05 13.1 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold adh_short PF00106.20 CCF42137.1 - 4.9e-27 94.8 2.2 1e-26 93.8 1.5 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF42137.1 - 9.6e-12 45.1 0.0 1.4e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF42137.1 - 2.6e-09 37.0 5.8 3.4e-08 33.3 4.0 2.1 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF42137.1 - 5e-07 29.8 0.2 1.3e-06 28.5 0.1 1.7 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF42137.1 - 8.4e-06 25.3 1.2 9.8e-06 25.1 0.2 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF42137.1 - 1.9e-05 23.4 0.4 2.9e-05 22.9 0.2 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 CCF42137.1 - 0.0033 16.3 0.0 0.0047 15.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.8 CCF42137.1 - 0.052 12.7 0.4 0.091 11.9 0.3 1.4 1 0 0 1 1 1 0 NmrA-like family 3HCDH_N PF02737.13 CCF42137.1 - 0.059 13.0 0.1 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.13 CCF42137.1 - 0.064 13.2 0.2 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain Methyltransf_23 PF13489.1 CCF42138.1 - 6.4e-20 71.4 0.0 8.8e-20 71.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF42138.1 - 1.8e-11 44.3 0.0 3.4e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF42138.1 - 2.5e-11 44.1 0.0 9.8e-11 42.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF42138.1 - 2.4e-09 36.9 0.0 1.5e-08 34.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF42138.1 - 2.5e-09 37.5 0.0 1.1e-08 35.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF42138.1 - 2.2e-05 24.7 0.0 5.3e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 CCF42138.1 - 0.0043 16.2 0.0 0.0073 15.5 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_4 PF02390.12 CCF42138.1 - 0.0071 15.4 0.0 0.022 13.8 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_26 PF13659.1 CCF42138.1 - 0.0074 16.3 0.0 0.021 14.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 CCF42138.1 - 0.012 15.6 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase CheR PF01739.13 CCF42138.1 - 0.015 14.5 0.0 0.033 13.4 0.0 1.5 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain CMAS PF02353.15 CCF42138.1 - 0.045 12.8 0.0 0.096 11.7 0.0 1.5 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 CCF42138.1 - 0.053 12.6 0.0 0.25 10.4 0.0 1.9 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family MTS PF05175.9 CCF42138.1 - 0.053 12.8 0.0 0.085 12.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.8 CCF42138.1 - 0.14 11.2 0.0 0.21 10.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) EXS PF03124.9 CCF42140.1 - 1.8e-103 346.2 7.1 2e-103 346.0 4.9 1.0 1 0 0 1 1 1 1 EXS family DAO PF01266.19 CCF42142.1 - 1.1e-40 139.6 0.0 1.5e-40 139.2 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 CCF42142.1 - 1.1e-08 34.6 0.2 8.8e-06 25.0 0.1 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CCF42142.1 - 2.3e-08 33.3 2.7 0.0031 16.4 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.9 CCF42142.1 - 0.00041 20.2 0.0 0.0011 18.8 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CCF42142.1 - 0.0024 16.8 0.1 0.091 11.6 0.0 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A 3HCDH_N PF02737.13 CCF42142.1 - 0.0042 16.7 0.0 0.0071 16.0 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.22 CCF42142.1 - 0.019 15.3 0.6 0.076 13.4 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF42142.1 - 0.021 14.8 0.1 0.081 12.9 0.1 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 CCF42142.1 - 0.027 12.9 0.2 0.038 12.4 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.12 CCF42142.1 - 0.038 13.0 0.3 0.78 8.7 0.0 2.6 3 0 0 3 3 3 0 Thi4 family Pyr_redox_3 PF13738.1 CCF42142.1 - 0.047 13.7 0.2 0.63 10.0 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF42142.1 - 0.052 12.4 0.2 0.18 10.6 0.1 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_10 PF13460.1 CCF42142.1 - 0.099 12.6 1.2 0.21 11.5 0.1 2.1 3 0 0 3 3 3 0 NADH(P)-binding Alpha-amylase PF00128.19 CCF42143.1 - 2.9e-95 319.3 0.0 4e-95 318.8 0.0 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF4434 PF14488.1 CCF42143.1 - 0.023 14.4 0.0 0.046 13.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) hDGE_amylase PF14701.1 CCF42143.1 - 0.05 12.5 0.0 0.077 11.8 0.0 1.2 1 0 0 1 1 1 0 glucanotransferase domain of human glycogen debranching enzyme CRC_subunit PF08624.5 CCF42144.1 - 1.2e-57 193.7 0.0 1.9e-57 193.0 0.0 1.3 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Daxx PF03344.10 CCF42144.1 - 0.0017 16.9 16.0 0.0026 16.3 11.1 1.2 1 0 0 1 1 1 1 Daxx Family Nop14 PF04147.7 CCF42144.1 - 0.091 10.6 10.6 0.11 10.3 7.4 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 CCF42144.1 - 1 7.3 6.5 1.4 6.8 4.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Neisseria_TspB PF05616.8 CCF42144.1 - 3.7 5.8 9.5 5.1 5.3 6.6 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein DUF2890 PF11081.3 CCF42144.1 - 4.1 7.4 14.6 7.1 6.6 10.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Abhydrolase_6 PF12697.2 CCF42145.1 - 4.7e-18 65.9 3.3 4.7e-18 65.9 2.3 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF42145.1 - 6.4e-10 38.9 1.9 9.6e-10 38.3 0.1 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF42145.1 - 2.6e-09 37.0 0.5 5.5e-09 35.9 0.4 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 CCF42145.1 - 1.6e-05 24.6 0.0 2.7e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Putative lysophospholipase DLH PF01738.13 CCF42145.1 - 0.015 14.6 0.0 0.024 13.9 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family Thioesterase PF00975.15 CCF42145.1 - 0.028 14.6 0.1 0.041 14.1 0.1 1.3 1 0 0 1 1 1 0 Thioesterase domain Lipase_3 PF01764.20 CCF42145.1 - 4 7.0 5.6 0.57 9.8 0.5 1.9 2 0 0 2 2 2 0 Lipase (class 3) PNPOx_C PF10590.4 CCF42146.1 - 1.7e-22 78.5 2.1 2.1e-22 78.3 1.5 1.1 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region DUF3833 PF12915.2 CCF42146.1 - 0.056 12.6 0.2 0.065 12.4 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3833) Cyclin_N PF00134.18 CCF42147.1 - 1.4e-06 27.9 0.1 2.3e-05 23.9 0.0 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Abhydrolase_6 PF12697.2 CCF42149.1 - 8e-27 94.5 0.1 1e-26 94.2 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF42149.1 - 7.6e-16 58.3 0.5 2.5e-14 53.3 0.4 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF42149.1 - 3.1e-08 33.5 0.0 5.2e-08 32.7 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CCF42149.1 - 1.5e-07 31.1 0.0 3.1e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase BAAT_C PF08840.6 CCF42149.1 - 0.048 13.3 0.0 0.47 10.1 0.0 2.0 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal WD40 PF00400.27 CCF42150.1 - 1.3e-26 91.4 0.3 2.8e-07 30.1 0.0 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat DUF3639 PF12341.3 CCF42150.1 - 8.8e-10 38.4 5.3 1.5e-09 37.6 1.6 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3639) Apc4_WD40 PF12894.2 CCF42150.1 - 0.00011 21.6 0.0 2.6 7.6 0.0 3.6 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.6 CCF42150.1 - 0.00011 21.9 0.0 0.00088 19.0 0.0 2.2 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.9 CCF42150.1 - 0.0034 16.2 0.0 0.0074 15.1 0.0 1.5 1 1 0 1 1 1 1 Coatomer WD associated region PQQ_3 PF13570.1 CCF42150.1 - 0.0082 16.3 3.8 0.87 9.9 0.1 4.7 4 1 0 4 4 4 1 PQQ-like domain IKI3 PF04762.7 CCF42150.1 - 0.016 13.0 0.1 0.082 10.7 0.0 1.9 2 1 0 2 2 2 0 IKI3 family Bd3614_N PF14442.1 CCF42150.1 - 0.046 13.6 1.4 0.12 12.3 1.0 1.7 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal BBS2_Mid PF14783.1 CCF42150.1 - 0.18 11.6 0.0 1.5 8.5 0.0 2.5 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.27 CCF42151.1 - 3.5e-16 58.3 14.5 0.00011 21.9 0.0 6.8 6 1 0 6 6 6 5 WD domain, G-beta repeat PQQ_3 PF13570.1 CCF42151.1 - 0.022 15.0 0.2 0.37 11.1 0.0 2.9 2 0 0 2 2 2 0 PQQ-like domain Ribosomal_60s PF00428.14 CCF42151.1 - 7.7 6.9 17.5 26 5.2 0.0 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Chitin_bind_1 PF00187.14 CCF42152.1 - 6.8e-05 22.7 20.1 6.8e-05 22.7 14.0 1.7 1 1 0 1 1 1 1 Chitin recognition protein adh_short PF00106.20 CCF42153.1 - 9.3e-29 100.4 1.0 1e-28 100.3 0.7 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF42153.1 - 5.4e-13 49.2 0.1 7e-13 48.8 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF42153.1 - 8.1e-13 48.4 0.2 9.5e-13 48.1 0.2 1.0 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF42153.1 - 0.00014 21.3 0.2 0.00016 21.1 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.14 CCF42153.1 - 0.0016 17.5 0.4 0.0032 16.5 0.1 1.6 1 1 1 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1776 PF08643.5 CCF42153.1 - 0.011 14.8 0.0 0.047 12.8 0.0 1.8 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) 3HCDH_N PF02737.13 CCF42153.1 - 0.017 14.7 1.9 0.027 14.1 1.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 CCF42153.1 - 0.019 13.9 0.5 0.024 13.6 0.3 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase Cas_Cas02710 PF09670.5 CCF42153.1 - 0.029 12.9 0.2 0.036 12.7 0.1 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas02710) Eno-Rase_NADH_b PF12242.3 CCF42153.1 - 0.046 13.5 2.6 0.064 13.0 1.2 1.7 1 1 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase YjeF_N PF03853.10 CCF42153.1 - 0.072 12.6 0.1 0.085 12.4 0.0 1.2 1 0 0 1 1 1 0 YjeF-related protein N-terminus DFP PF04127.10 CCF42153.1 - 0.076 12.6 2.4 0.15 11.6 1.6 1.6 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein BDV_P24 PF06595.6 CCF42153.1 - 0.086 12.6 0.1 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Borna disease virus P24 protein NAD_binding_10 PF13460.1 CCF42153.1 - 0.086 12.8 1.9 0.16 11.9 1.3 1.5 1 1 0 1 1 1 0 NADH(P)-binding ketoacyl-synt PF00109.21 CCF42155.1 - 3.1e-35 121.8 0.0 4.4e-35 121.3 0.0 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 CCF42156.1 - 2.2e-43 146.8 0.0 3.1e-43 146.4 0.0 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.16 CCF42156.1 - 4.9e-11 42.5 0.1 6.9e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.21 CCF42156.1 - 1.4e-06 28.0 0.1 5e-06 26.1 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ERG2_Sigma1R PF04622.7 CCF42157.1 - 6.9e-96 319.6 0.3 7.7e-96 319.4 0.2 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein UCR_6-4kD PF08997.5 CCF42157.1 - 0.088 12.5 0.3 2.8 7.7 0.0 2.5 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein ECH PF00378.15 CCF42159.1 - 5e-35 120.7 0.1 1.5e-31 109.4 0.1 2.5 2 1 0 2 2 2 2 Enoyl-CoA hydratase/isomerase family Glyco_trans_4_4 PF13579.1 CCF42159.1 - 0.0055 16.8 0.0 0.28 11.2 0.1 2.4 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain eIF2A PF08662.6 CCF42160.1 - 1.8e-41 142.0 3.1 6.2e-37 127.1 0.2 3.6 2 2 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40 PF00400.27 CCF42160.1 - 1.4e-05 24.7 1.7 0.99 9.3 0.0 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat RRM_6 PF14259.1 CCF42160.1 - 0.00019 21.3 0.0 0.00072 19.4 0.0 2.1 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CCF42160.1 - 0.00033 20.2 0.0 0.00067 19.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF42160.1 - 0.0022 17.7 0.0 0.005 16.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP3 PF08572.5 CCF42160.1 - 0.064 12.6 1.0 0.11 11.8 0.7 1.3 1 0 0 1 1 1 0 pre-mRNA processing factor 3 (PRP3) CCDC92 PF14916.1 CCF42161.1 - 0.044 13.3 0.2 0.13 11.8 0.1 1.7 1 0 0 1 1 1 0 Coiled-coil domain of unknown function Stn1 PF10451.4 CCF42163.1 - 7.4e-11 41.3 0.1 0.00014 20.7 0.0 2.0 2 0 0 2 2 2 2 Telomere regulation protein Stn1 Acyl_transf_1 PF00698.16 CCF42165.1 - 1.3e-37 129.8 0.6 2.1e-37 129.1 0.4 1.3 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.1 CCF42165.1 - 2.9e-13 49.6 0.1 5.6e-13 48.6 0.1 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase PP-binding PF00550.20 CCF42165.1 - 4.5e-07 30.0 0.3 1.1e-06 28.8 0.2 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site DUF915 PF06028.6 CCF42165.1 - 0.015 14.3 0.0 3 6.8 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_5 PF12695.2 CCF42165.1 - 0.024 14.4 0.1 0.066 12.9 0.0 1.7 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF42165.1 - 0.065 13.1 1.9 0.16 11.7 1.0 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase family FHA PF00498.21 CCF42166.1 - 1.5e-15 57.0 0.0 3e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 FHA domain zf-RING_2 PF13639.1 CCF42166.1 - 3e-06 26.9 12.4 5.1e-06 26.2 8.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 CCF42166.1 - 9.7e-06 25.6 7.7 1.8e-05 24.7 5.4 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 CCF42166.1 - 0.011 15.3 12.8 0.019 14.6 8.9 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CCF42166.1 - 0.17 11.7 3.3 0.34 10.7 2.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger lci PF12197.3 CCF42166.1 - 0.19 11.3 2.9 0.16 11.5 0.7 1.8 2 0 0 2 2 2 0 Bacillus cereus group antimicrobial protein PHD PF00628.24 CCF42166.1 - 0.3 10.8 7.9 0.56 9.9 5.5 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING_5 PF14634.1 CCF42166.1 - 0.46 10.2 10.5 0.77 9.5 7.3 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CCF42166.1 - 2.8 8.0 14.2 4.8 7.2 9.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Mt_ATP-synt_D PF05873.7 CCF42167.1 - 2.4e-19 69.5 0.7 3e-19 69.2 0.5 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) Abhydrolase_3 PF07859.8 CCF42168.1 - 1.4e-33 116.2 0.2 2e-33 115.7 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF42168.1 - 9.9e-10 38.6 3.3 1.7e-09 37.9 2.3 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF42168.1 - 0.00047 19.9 0.4 0.00076 19.2 0.3 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF42168.1 - 0.02 14.4 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2424 PF10340.4 CCF42168.1 - 0.042 12.4 0.0 0.059 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2424) Peptidase_S9 PF00326.16 CCF42168.1 - 0.047 12.9 0.2 0.11 11.7 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family Pkinase PF00069.20 CCF42169.1 - 2.9e-40 138.0 0.0 6e-40 137.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF42169.1 - 3e-22 78.9 0.0 5.3e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Hex_IIIa PF02455.11 CCF42169.1 - 1.5 7.3 4.5 3.3 6.2 3.1 1.4 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) Alpha_L_fucos PF01120.12 CCF42172.1 - 6.9e-86 288.2 0.6 9e-86 287.9 0.4 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase GHL6 PF14871.1 CCF42172.1 - 0.019 15.0 0.2 0.065 13.2 0.0 2.0 2 0 0 2 2 2 0 Hypothetical glycosyl hydrolase 6 RdRP PF05183.7 CCF42174.1 - 2e-174 581.5 0.0 2.8e-174 581.0 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase RRM_6 PF14259.1 CCF42174.1 - 5.1e-05 23.1 0.0 0.029 14.3 0.0 3.0 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CCF42174.1 - 7.7e-05 22.2 0.0 0.0011 18.6 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAD-oxidase_C PF02913.14 CCF42175.1 - 7.5e-61 205.5 0.1 1.4e-60 204.7 0.0 1.5 2 0 0 2 2 2 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 CCF42175.1 - 3.6e-34 117.2 0.1 1.1e-33 115.6 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain SLA_LP_auto_ag PF05889.8 CCF42175.1 - 0.06 11.8 0.0 0.097 11.1 0.0 1.3 1 0 0 1 1 1 0 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) LysM PF01476.15 CCF42176.1 - 0.0089 15.9 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 LysM domain Med3 PF11593.3 CCF42176.1 - 0.023 13.9 0.8 0.023 13.9 0.5 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Sporozoite_P67 PF05642.6 CCF42176.1 - 1.1 7.0 7.7 1.3 6.8 5.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen BLVR PF06375.6 CCF42178.1 - 0.62 9.8 13.3 1.4 8.7 9.2 1.7 1 1 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) CDC27 PF09507.5 CCF42178.1 - 1.2 8.2 25.6 1.6 7.8 17.8 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Draxin PF15550.1 CCF42178.1 - 1.4 8.5 20.5 1.7 8.2 14.2 1.0 1 0 0 1 1 1 0 Draxin CENP-I PF07778.6 CCF42178.1 - 2.4 6.2 5.4 3.2 5.8 3.7 1.2 1 0 0 1 1 1 0 Mis6 PAT1 PF09770.4 CCF42178.1 - 3.2 5.8 48.6 3.7 5.6 33.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CCF42178.1 - 5.4 5.0 49.8 6.9 4.7 34.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Parvo_coat PF00740.13 CCF42178.1 - 6.5 5.5 27.3 7.8 5.3 18.9 1.0 1 0 0 1 1 1 0 Parvovirus coat protein VP2 Peptidase_S8 PF00082.17 CCF42179.1 - 1.5e-11 44.0 1.4 3.5e-11 42.7 1.0 1.6 1 1 0 1 1 1 1 Subtilase family HypD PF01924.11 CCF42179.1 - 0.081 11.6 0.1 0.12 11.0 0.1 1.2 1 0 0 1 1 1 0 Hydrogenase formation hypA family Ank_2 PF12796.2 CCF42181.1 - 3.8e-21 75.2 0.3 5.5e-09 36.2 0.2 3.4 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.1 CCF42181.1 - 7.1e-20 70.5 5.9 1.6e-05 24.9 0.1 4.6 4 0 0 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 CCF42181.1 - 7.3e-19 67.7 2.3 9.1e-06 26.0 0.0 4.9 4 1 1 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.25 CCF42181.1 - 5e-16 57.6 14.8 9.7e-05 21.9 0.1 6.3 5 1 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.1 CCF42181.1 - 4.7e-14 51.1 3.1 0.0019 18.2 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat F-box-like PF12937.2 CCF42181.1 - 0.00075 19.1 0.0 0.0022 17.6 0.0 1.8 1 1 0 1 1 1 1 F-box-like Tet_JBP PF12851.2 CCF42181.1 - 0.018 14.3 0.0 0.025 13.8 0.0 1.4 1 0 0 1 1 1 0 Oxygenase domain of the 2OGFeDO superfamily NST1 PF13945.1 CCF42182.1 - 0.046 13.7 0.5 0.059 13.4 0.3 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Sec62 PF03839.11 CCF42183.1 - 8.1e-51 172.5 0.4 1.2e-50 172.0 0.3 1.2 1 0 0 1 1 1 1 Translocation protein Sec62 Zip PF02535.17 CCF42183.1 - 0.28 10.1 1.5 0.33 9.9 0.2 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter SelP_N PF04592.9 CCF42183.1 - 1.7 7.9 5.0 3 7.1 3.5 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Bac_rhamnosid_N PF08531.5 CCF42184.1 - 0.032 13.7 0.0 0.033 13.7 0.0 1.0 1 0 0 1 1 1 0 Alpha-L-rhamnosidase N-terminal domain PTPS_related PF10131.4 CCF42185.1 - 0.0068 14.6 0.5 0.0083 14.3 0.4 1.0 1 0 0 1 1 1 1 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein NAD_Gly3P_dh_N PF01210.18 CCF42186.1 - 6.3e-48 162.4 0.0 3.3e-47 160.1 0.0 1.9 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.9 CCF42186.1 - 3.8e-42 143.5 0.3 5.9e-42 142.9 0.2 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus SopE_GEF PF07487.8 CCF42186.1 - 0.015 15.2 0.0 0.11 12.4 0.0 2.0 2 0 0 2 2 2 0 SopE GEF domain ABC_membrane PF00664.18 CCF42187.1 - 7.3e-77 258.4 35.3 1.9e-38 132.4 10.6 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 CCF42187.1 - 2.2e-70 235.3 0.0 9e-34 116.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 CCF42187.1 - 1.1e-13 50.9 0.1 2.1e-05 23.8 0.0 4.0 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF42187.1 - 8.1e-13 48.9 0.1 0.0022 17.9 0.2 4.4 3 1 0 3 3 3 3 AAA domain AAA_29 PF13555.1 CCF42187.1 - 2.2e-09 36.7 0.7 0.00039 19.9 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.4 CCF42187.1 - 3.9e-08 32.2 0.0 0.028 13.0 0.0 3.7 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_16 PF13191.1 CCF42187.1 - 4.7e-08 33.2 1.1 0.0021 18.0 0.1 2.9 2 2 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.11 CCF42187.1 - 1.9e-07 30.3 0.0 0.013 14.7 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 CCF42187.1 - 5.6e-07 30.3 0.0 0.062 14.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 CCF42187.1 - 2e-06 27.9 0.6 0.21 11.7 0.1 4.0 2 2 0 2 2 2 2 AAA domain AAA_25 PF13481.1 CCF42187.1 - 2.1e-06 27.3 0.5 0.035 13.5 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_33 PF13671.1 CCF42187.1 - 0.00033 20.5 0.0 1.1 9.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 CCF42187.1 - 0.00041 19.5 0.0 1.2 8.2 0.0 2.9 3 0 0 3 3 3 2 Zeta toxin AAA_30 PF13604.1 CCF42187.1 - 0.00065 19.3 0.5 2.4 7.6 0.0 3.8 4 0 0 4 4 4 1 AAA domain AAA_28 PF13521.1 CCF42187.1 - 0.00085 19.3 0.0 0.79 9.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain SbcCD_C PF13558.1 CCF42187.1 - 0.00086 19.1 1.3 2.1 8.3 0.1 3.4 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.1 CCF42187.1 - 0.0011 18.9 0.0 6.4 6.7 0.0 3.6 4 0 0 4 4 3 0 AAA domain AAA_23 PF13476.1 CCF42187.1 - 0.0017 18.7 0.5 0.66 10.2 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_18 PF13238.1 CCF42187.1 - 0.0023 18.2 0.0 1.4 9.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.12 CCF42187.1 - 0.0027 17.5 0.2 1.9 8.2 0.0 2.8 3 0 0 3 3 2 1 Domain of unknown function DUF87 AAA_5 PF07728.9 CCF42187.1 - 0.007 16.0 0.1 12 5.6 0.0 3.6 4 0 0 4 4 3 0 AAA domain (dynein-related subfamily) MobB PF03205.9 CCF42187.1 - 0.0076 15.9 0.0 3.9 7.1 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_15 PF13175.1 CCF42187.1 - 0.011 14.7 0.0 3.9 6.4 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA PF00004.24 CCF42187.1 - 0.012 15.7 0.5 19 5.4 0.0 4.3 5 0 0 5 5 4 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.18 CCF42187.1 - 0.013 15.4 0.0 5.2 7.0 0.0 2.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase APS_kinase PF01583.15 CCF42187.1 - 0.019 14.6 0.1 3.1 7.4 0.1 3.4 4 0 0 4 4 3 0 Adenylylsulphate kinase G-alpha PF00503.15 CCF42187.1 - 0.023 13.4 0.0 2 6.9 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit AAA_10 PF12846.2 CCF42187.1 - 0.065 12.6 0.7 11 5.4 0.0 3.3 3 0 0 3 3 3 0 AAA-like domain RNA_helicase PF00910.17 CCF42187.1 - 0.071 13.2 0.1 3.5 7.8 0.0 2.5 2 0 0 2 2 2 0 RNA helicase NB-ARC PF00931.17 CCF42187.1 - 0.19 10.5 0.9 4.4 6.0 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain RNase_PH PF01138.16 CCF42188.1 - 8.1e-18 65.0 0.0 2.7e-17 63.2 0.0 1.9 2 1 0 2 2 2 1 3' exoribonuclease family, domain 1 CHORD PF04968.7 CCF42189.1 - 0.022 14.9 4.9 0.055 13.7 0.7 2.6 2 1 0 2 2 2 0 CHORD NCKAP5 PF15246.1 CCF42189.1 - 0.053 12.8 0.1 0.067 12.5 0.1 1.1 1 0 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein BTK PF00779.14 CCF42189.1 - 0.33 10.5 2.8 4.8 6.8 0.8 2.5 2 0 0 2 2 2 0 BTK motif GDI PF00996.13 CCF42190.1 - 7.1e-39 133.3 0.0 8.5e-39 133.0 0.0 1.1 1 0 0 1 1 1 1 GDP dissociation inhibitor Chordopox_RPO7 PF05864.7 CCF42192.1 - 0.071 13.2 0.3 0.59 10.2 0.0 2.1 1 1 1 2 2 2 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) DUF3074 PF11274.3 CCF42195.1 - 1.8e-58 197.2 2.1 3e-54 183.4 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF3074) Macoilin PF09726.4 CCF42195.1 - 0.17 10.1 20.2 0.27 9.4 14.0 1.2 1 0 0 1 1 1 0 Transmembrane protein TPR_MLP1_2 PF07926.7 CCF42195.1 - 0.24 11.1 35.6 0.2 11.4 22.8 2.2 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF3584 PF12128.3 CCF42195.1 - 0.63 7.2 26.8 1.1 6.5 18.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF342 PF03961.8 CCF42195.1 - 2.2 6.6 14.8 4 5.7 10.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) CAF-1_p150 PF11600.3 CCF42195.1 - 2.9 7.2 44.0 0.079 12.3 25.3 2.0 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal AAA_13 PF13166.1 CCF42195.1 - 7.3 4.9 22.1 13 4.0 15.3 1.3 1 0 0 1 1 1 0 AAA domain APG6 PF04111.7 CCF42195.1 - 9.3 5.1 32.2 18 4.2 22.3 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 PAN_1 PF00024.21 CCF42197.1 - 1.1e-05 25.1 0.3 1.6e-05 24.5 0.2 1.3 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.1 CCF42197.1 - 0.00073 19.1 0.7 0.0014 18.2 0.5 1.5 1 0 0 1 1 1 1 PAN domain NAP PF00956.13 CCF42198.1 - 5.4e-88 294.2 11.5 5.4e-88 294.2 7.9 1.7 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) Adeno_E3_CR2 PF02439.10 CCF42199.1 - 0.11 12.0 0.3 0.21 11.1 0.2 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Kelch_4 PF13418.1 CCF42199.1 - 0.42 10.4 5.4 7.1 6.4 0.1 3.8 4 0 0 4 4 4 0 Galactose oxidase, central domain SKG6 PF08693.5 CCF42199.1 - 1.3 8.4 3.6 0.3 10.4 0.1 1.7 2 0 0 2 2 2 0 Transmembrane alpha-helix domain OPT PF03169.10 CCF42200.1 - 2.1e-162 541.8 56.1 2.4e-162 541.6 38.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Ammonium_transp PF00909.16 CCF42201.1 - 5.2e-117 390.6 26.6 6e-117 390.4 18.4 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family CoA_binding PF02629.14 CCF42203.1 - 3.1e-28 98.1 4.2 1.2e-27 96.2 0.7 2.3 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.14 CCF42203.1 - 1.5e-23 83.0 0.3 2.6e-23 82.3 0.2 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.1 CCF42203.1 - 3.7e-09 36.2 0.0 6.7e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.1 CCF42203.1 - 4.4e-05 23.6 0.1 0.00023 21.3 0.0 2.2 3 0 0 3 3 3 1 CoA binding domain GFO_IDH_MocA PF01408.17 CCF42203.1 - 0.00088 19.7 0.1 0.0021 18.5 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Asp PF00026.18 CCF42205.1 - 4.6e-40 137.8 0.0 6.2e-40 137.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CCF42205.1 - 0.0024 17.8 0.0 0.0063 16.4 0.0 1.7 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 CCF42205.1 - 0.0058 17.1 0.2 3.6 8.1 0.0 3.3 2 1 0 2 2 2 2 Aspartyl protease Ank PF00023.25 CCF42206.1 - 9.5e-47 154.5 14.4 2.3e-08 33.4 0.1 8.4 8 0 0 8 8 8 7 Ankyrin repeat Ank_2 PF12796.2 CCF42206.1 - 1.5e-46 156.6 2.9 4.8e-20 71.6 0.2 3.5 3 0 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.1 CCF42206.1 - 2.2e-38 126.4 1.6 1.9e-06 27.5 0.0 8.3 8 0 0 8 8 8 7 Ankyrin repeat Ank_5 PF13857.1 CCF42206.1 - 4.9e-36 121.9 10.0 7.6e-08 32.3 0.0 8.3 4 2 5 9 9 9 7 Ankyrin repeats (many copies) Ank_4 PF13637.1 CCF42206.1 - 9.4e-29 99.2 1.8 2.3e-08 34.3 0.1 6.6 2 2 5 8 8 8 8 Ankyrin repeats (many copies) NACHT PF05729.7 CCF42206.1 - 0.0021 17.7 0.2 0.0043 16.7 0.1 1.4 1 0 0 1 1 1 1 NACHT domain DUF3021 PF11457.3 CCF42207.1 - 0.51 10.2 5.3 0.22 11.4 1.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3021) Zip PF02535.17 CCF42207.1 - 0.85 8.5 7.0 0.036 13.0 0.8 1.7 2 1 1 3 3 3 0 ZIP Zinc transporter DUF3328 PF11807.3 CCF42208.1 - 1.5e-07 31.3 0.0 1.7e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) TilS_C PF11734.3 CCF42208.1 - 0.036 13.2 0.0 0.057 12.6 0.0 1.2 1 0 0 1 1 1 0 TilS substrate C-terminal domain Peptidase_S10 PF00450.17 CCF42209.1 - 5.3e-50 170.7 3.8 6.6e-50 170.4 2.6 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase GHMP_kinases_N PF00288.21 CCF42209.1 - 0.04 13.9 0.6 3 7.9 0.0 2.3 2 0 0 2 2 2 0 GHMP kinases N terminal domain Sugar_tr PF00083.19 CCF42210.1 - 7.7e-18 64.2 6.5 8.5e-18 64.1 4.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter PQ-loop PF04193.9 CCF42210.1 - 0.052 13.1 0.7 0.12 11.9 0.5 1.6 1 0 0 1 1 1 0 PQ loop repeat DUF4118 PF13493.1 CCF42210.1 - 0.091 12.9 0.5 0.091 12.9 0.3 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4118) SDF PF00375.13 CCF42211.1 - 4.9e-37 127.6 18.2 6.1e-37 127.3 12.6 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family 7tm_1 PF00001.16 CCF42211.1 - 0.016 14.3 0.9 0.024 13.7 0.6 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Protoglobin PF11563.3 CCF42212.1 - 5.3e-58 195.1 0.1 6.3e-58 194.9 0.1 1.1 1 0 0 1 1 1 1 Protoglobin Cys_Met_Meta_PP PF01053.15 CCF42213.1 - 1e-30 106.3 0.0 1.2e-30 106.1 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme TFIIF_alpha PF05793.7 CCF42214.1 - 0.011 14.1 10.2 0.017 13.5 7.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Protocadherin PF08374.6 CCF42214.1 - 0.19 11.3 3.8 0.21 11.1 2.6 1.2 1 0 0 1 1 1 0 Protocadherin DUF3827 PF12877.2 CCF42214.1 - 0.66 8.0 3.4 0.74 7.8 2.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) SPT6_acidic PF14632.1 CCF42214.1 - 2.1 8.5 8.9 0.25 11.5 2.1 2.0 2 0 0 2 2 2 0 Acidic N-terminal SPT6 PGA2 PF07543.7 CCF42214.1 - 4.6 7.0 8.2 0.38 10.5 2.6 1.5 2 0 0 2 2 2 0 Protein trafficking PGA2 BAR PF03114.13 CCF42216.1 - 1.7e-47 161.8 4.2 2.4e-47 161.4 2.9 1.2 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.4 CCF42216.1 - 1.1e-07 31.0 1.1 1.4e-07 30.7 0.8 1.1 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking PMEI PF04043.10 CCF42216.1 - 0.036 13.9 0.2 0.062 13.1 0.2 1.5 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor Herpes_UL25 PF01499.11 CCF42216.1 - 0.07 11.4 1.1 0.085 11.1 0.8 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family Oxysterol_BP PF01237.13 CCF42216.1 - 0.32 9.4 2.2 0.5 8.8 1.5 1.2 1 0 0 1 1 1 0 Oxysterol-binding protein GBP_C PF02841.9 CCF42216.1 - 0.45 9.6 6.3 0.71 8.9 4.4 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain IncA PF04156.9 CCF42216.1 - 0.93 9.0 4.6 1.5 8.3 3.2 1.3 1 0 0 1 1 1 0 IncA protein DUF883 PF05957.8 CCF42216.1 - 1.2 9.5 7.6 4.6 7.7 5.3 2.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) APG6 PF04111.7 CCF42216.1 - 9 5.2 10.5 2.5 7.0 5.3 1.4 2 0 0 2 2 2 0 Autophagy protein Apg6 Tom5 PF10642.4 CCF42217.1 - 0.093 12.3 0.4 0.16 11.6 0.2 1.3 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase Glyco_hydro_62 PF03664.8 CCF42219.1 - 6e-148 491.2 9.3 6.8e-148 491.0 6.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 62 DivIVA PF05103.8 CCF42220.1 - 0.098 12.7 4.4 0.53 10.3 2.6 2.4 1 1 1 2 2 2 0 DivIVA protein F-box-like PF12937.2 CCF42221.1 - 3.9e-11 42.5 0.0 7.8e-11 41.5 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF42221.1 - 0.00097 18.7 0.0 0.0023 17.5 0.0 1.6 1 0 0 1 1 1 1 F-box domain Mito_carr PF00153.22 CCF42222.1 - 4.3e-61 202.6 0.7 3.9e-21 74.5 0.1 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein Sugar_tr PF00083.19 CCF42223.1 - 1.2e-79 268.0 12.6 1.3e-79 267.8 8.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF42223.1 - 3.2e-29 101.7 17.2 4.4e-29 101.2 11.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF42223.1 - 0.00059 18.1 2.9 0.0061 14.8 0.2 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) DUF3021 PF11457.3 CCF42223.1 - 0.68 9.8 9.9 1.9 8.4 6.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) FAD_binding_3 PF01494.14 CCF42224.1 - 8.4e-23 80.9 0.0 1e-15 57.7 0.0 2.3 2 1 0 2 2 2 2 FAD binding domain DAO PF01266.19 CCF42224.1 - 6.6e-07 28.5 0.2 9.4e-05 21.4 0.1 2.5 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CCF42224.1 - 7.9e-06 24.9 0.1 1.3e-05 24.2 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 CCF42224.1 - 5.3e-05 23.1 0.0 0.00012 22.0 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF42224.1 - 6.1e-05 22.9 0.4 0.00014 21.7 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.5 CCF42224.1 - 6.4e-05 21.9 0.1 0.007 15.2 0.0 2.4 2 1 1 3 3 3 1 Squalene epoxidase Pyr_redox PF00070.22 CCF42224.1 - 0.00033 20.9 0.6 0.003 17.9 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CCF42224.1 - 0.00067 18.6 0.0 0.0025 16.7 0.0 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.12 CCF42224.1 - 0.0017 17.4 0.2 0.0031 16.6 0.2 1.4 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.9 CCF42224.1 - 0.0026 16.2 0.1 0.0049 15.3 0.1 1.4 1 0 0 1 1 1 1 HI0933-like protein Trp_halogenase PF04820.9 CCF42224.1 - 0.0046 15.6 0.0 1.7 7.2 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase AlaDh_PNT_C PF01262.16 CCF42224.1 - 0.0052 16.3 1.4 0.012 15.2 0.1 2.2 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.2 CCF42224.1 - 0.0061 15.6 0.2 0.01 14.9 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 CCF42224.1 - 0.033 14.2 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Clathrin PF00637.15 CCF42224.1 - 0.089 12.3 0.1 0.2 11.2 0.1 1.5 1 0 0 1 1 1 0 Region in Clathrin and VPS Lycopene_cycl PF05834.7 CCF42224.1 - 0.096 11.5 0.2 0.88 8.4 0.1 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein A_thal_3526 PF09713.5 CCF42224.1 - 0.12 12.5 0.0 0.37 10.9 0.0 1.8 1 0 0 1 1 1 0 Plant protein 1589 of unknown function (A_thal_3526) 3HCDH_N PF02737.13 CCF42224.1 - 0.12 12.0 0.3 0.26 10.9 0.2 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.10 CCF42225.1 - 1.8e-24 86.4 0.0 2.7e-24 85.8 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 CCF42225.1 - 3.8e-10 39.8 0.0 6.5e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.12 CCF42225.1 - 0.0012 19.1 0.0 0.003 17.9 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Antimicrobial11 PF08106.6 CCF42225.1 - 0.11 12.3 0.4 0.23 11.3 0.3 1.6 1 0 0 1 1 1 0 Formaecin family GDPD PF03009.12 CCF42227.1 - 0.12 11.8 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family RNA_pol_Rpc34 PF05158.7 CCF42228.1 - 4.4e-100 335.0 0.0 5.4e-100 334.7 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit RPA_C PF08784.6 CCF42228.1 - 0.0053 17.1 0.0 0.063 13.7 0.0 2.6 2 0 0 2 2 2 1 Replication protein A C terminal B-block_TFIIIC PF04182.7 CCF42228.1 - 0.047 13.5 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC NMT_C PF02799.10 CCF42233.1 - 4.9e-75 251.0 0.0 7e-75 250.5 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.14 CCF42233.1 - 1.3e-72 242.7 0.0 2.5e-72 241.7 0.0 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.1 CCF42233.1 - 1.3e-05 25.0 0.1 0.00084 19.2 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Band_7 PF01145.20 CCF42234.1 - 1.2e-25 90.4 4.4 2e-25 89.7 3.1 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF2884 PF11101.3 CCF42234.1 - 0.011 15.1 1.9 0.014 14.7 0.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2884) UcrQ PF02939.11 CCF42235.1 - 3.1e-34 116.6 0.2 3.7e-34 116.4 0.1 1.0 1 0 0 1 1 1 1 UcrQ family zf-RAG1 PF10426.4 CCF42235.1 - 0.2 11.6 0.6 0.31 11.0 0.4 1.2 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain MaoC_dehydratas PF01575.14 CCF42236.1 - 6.4e-24 83.6 0.0 8.2e-24 83.3 0.0 1.1 1 0 0 1 1 1 1 MaoC like domain ECH PF00378.15 CCF42237.1 - 4.3e-38 130.8 0.0 5.4e-38 130.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family ECH PF00378.15 CCF42238.1 - 4.9e-52 176.4 0.0 6e-52 176.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family TRI12 PF06609.8 CCF42239.1 - 9.5e-82 275.0 19.1 1.2e-81 274.7 13.2 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.11 CCF42239.1 - 1e-26 93.5 48.4 1e-26 93.5 33.5 2.2 2 0 0 2 2 2 1 Major Facilitator Superfamily adh_short PF00106.20 CCF42240.1 - 1.4e-32 112.8 3.9 2.2e-32 112.2 2.7 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF42240.1 - 8.6e-28 97.7 0.8 1e-27 97.4 0.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF42240.1 - 4.1e-15 55.9 2.7 6.1e-15 55.3 1.9 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF42240.1 - 0.0045 16.4 0.5 0.026 13.9 0.3 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Ldh_1_N PF00056.18 CCF42240.1 - 0.0062 16.3 0.2 0.01 15.6 0.1 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 CCF42240.1 - 0.016 14.8 0.4 0.025 14.2 0.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH PF00378.15 CCF42241.1 - 3.7e-26 91.7 0.7 6e-22 77.9 0.1 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase family Epimerase PF01370.16 CCF42242.1 - 7.6e-15 54.9 0.1 2.7e-14 53.1 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF42242.1 - 1.4e-14 54.5 1.1 3.6e-14 53.1 0.7 1.7 1 1 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 CCF42242.1 - 5.5e-09 35.1 0.0 1.9e-08 33.3 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 CCF42242.1 - 0.0004 19.4 0.1 0.012 14.5 0.1 2.0 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.8 CCF42242.1 - 0.0021 17.3 0.2 0.004 16.4 0.1 1.4 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.20 CCF42242.1 - 0.027 14.3 2.4 0.032 14.1 0.4 2.0 2 1 0 2 2 2 0 short chain dehydrogenase RmlD_sub_bind PF04321.12 CCF42242.1 - 0.068 12.0 0.1 1.2 7.9 0.0 2.1 2 0 0 2 2 2 0 RmlD substrate binding domain bZIP_1 PF00170.16 CCF42245.1 - 0.00029 20.7 8.4 0.00053 19.9 5.8 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 CCF42245.1 - 0.004 16.9 8.2 0.0062 16.3 5.7 1.2 1 0 0 1 1 1 1 Basic region leucine zipper adh_short_C2 PF13561.1 CCF42246.1 - 8.3e-25 87.9 1.0 9.8e-25 87.7 0.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF42246.1 - 1.1e-19 70.9 4.8 1.7e-19 70.3 3.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF42246.1 - 3.4e-09 36.6 3.2 4.9e-09 36.1 2.2 1.2 1 0 0 1 1 1 1 KR domain Cupin_2 PF07883.6 CCF42247.1 - 3e-13 49.0 0.0 4.8e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.7 CCF42247.1 - 8.6e-06 25.0 0.0 1.4e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) AraC_binding PF02311.14 CCF42247.1 - 0.0052 16.4 0.0 0.0071 16.0 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain AraC_binding_2 PF14525.1 CCF42247.1 - 0.056 13.0 0.0 0.098 12.2 0.0 1.5 1 1 0 1 1 1 0 AraC-binding-like domain adh_short PF00106.20 CCF42250.1 - 7.1e-07 29.2 0.0 1.7e-06 28.0 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase Methyltransf_26 PF13659.1 CCF42250.1 - 0.027 14.4 0.0 0.033 14.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain adh_short_C2 PF13561.1 CCF42250.1 - 0.042 13.6 0.0 0.057 13.1 0.0 1.1 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase p450 PF00067.17 CCF42253.1 - 8.7e-55 186.0 0.0 1.1e-54 185.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 COesterase PF00135.23 CCF42254.1 - 7.6e-74 249.3 0.0 9.6e-74 248.9 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF42254.1 - 2.6e-08 33.7 0.1 2.4e-07 30.5 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF42254.1 - 0.00057 19.1 0.2 0.0009 18.5 0.2 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.15 CCF42254.1 - 0.035 13.5 0.0 3.7 6.8 0.0 2.3 2 0 0 2 2 2 0 Putative esterase FAD_binding_3 PF01494.14 CCF42256.1 - 6.1e-74 249.1 0.0 7.5e-74 248.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.7 CCF42256.1 - 8.8e-34 116.5 0.0 1.4e-33 115.9 0.0 1.3 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.9 CCF42256.1 - 1.4e-05 25.0 0.0 4.5e-05 23.4 0.0 1.8 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF42256.1 - 2.3e-05 24.7 0.1 0.0061 16.9 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF42256.1 - 6.6e-05 21.5 0.6 0.00014 20.5 0.2 1.6 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.1 CCF42256.1 - 0.00037 20.4 0.1 0.00086 19.2 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 CCF42256.1 - 0.0025 16.9 0.0 0.0044 16.1 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.1 CCF42256.1 - 0.0031 17.5 0.9 0.0088 16.1 0.6 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF42256.1 - 0.0046 15.9 0.2 0.007 15.3 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Trp_halogenase PF04820.9 CCF42256.1 - 0.0075 14.9 0.0 0.011 14.3 0.0 1.2 1 0 0 1 1 1 1 Tryptophan halogenase DAO PF01266.19 CCF42256.1 - 0.013 14.3 0.2 0.41 9.4 0.1 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase XdhC_C PF13478.1 CCF42256.1 - 0.042 14.1 0.0 0.085 13.1 0.0 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain GIDA PF01134.17 CCF42256.1 - 0.051 12.4 0.1 0.078 11.8 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A UDPG_MGDP_dh_N PF03721.9 CCF42256.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_2 PF00890.19 CCF42256.1 - 0.18 10.5 0.2 0.29 9.9 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain 3HCDH_N PF02737.13 CCF42256.1 - 0.29 10.7 0.0 0.45 10.1 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Condensation PF00668.15 CCF42257.1 - 2.4e-173 574.9 0.3 2.6e-53 180.8 0.0 4.9 4 1 0 4 4 4 4 Condensation domain AMP-binding PF00501.23 CCF42257.1 - 6e-157 522.3 0.0 8.1e-80 268.2 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme PP-binding PF00550.20 CCF42257.1 - 2.4e-36 123.8 0.0 4e-13 49.4 0.0 4.4 4 0 0 4 4 4 3 Phosphopantetheine attachment site HxxPF_rpt PF13745.1 CCF42257.1 - 1.7e-10 41.0 1.1 0.029 14.6 0.0 3.9 3 0 0 3 3 3 3 HxxPF-repeated domain AMP-binding_C PF13193.1 CCF42257.1 - 6.9e-05 23.7 0.0 0.046 14.6 0.0 3.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain AATase PF07247.7 CCF42257.1 - 0.089 11.3 0.3 1.3 7.4 0.0 3.1 4 1 0 4 4 4 0 Alcohol acetyltransferase O-FucT PF10250.4 CCF42258.1 - 0.00066 18.8 0.0 0.016 14.3 0.0 2.1 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase GN3L_Grn1 PF08701.6 CCF42259.1 - 4.5e-25 87.3 16.0 8e-25 86.5 11.1 1.4 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.18 CCF42259.1 - 4.4e-21 74.9 0.1 4e-15 55.7 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CCF42259.1 - 1.8e-07 30.7 0.0 0.008 15.6 0.0 2.4 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 CCF42259.1 - 2.5e-06 27.4 8.3 0.038 13.8 0.3 3.8 4 0 0 4 4 4 2 Dynamin family DUF258 PF03193.11 CCF42259.1 - 0.00033 19.8 0.1 0.00057 19.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Miro PF08477.8 CCF42259.1 - 0.00055 20.4 1.1 1.4 9.4 0.1 2.6 2 0 0 2 2 2 2 Miro-like protein FeoB_N PF02421.13 CCF42259.1 - 0.0011 18.3 0.4 0.02 14.1 0.1 2.5 2 1 0 2 2 2 1 Ferrous iron transport protein B AIG1 PF04548.11 CCF42259.1 - 0.028 13.5 0.2 0.078 12.0 0.1 1.7 2 0 0 2 2 2 0 AIG1 family ArgK PF03308.11 CCF42259.1 - 0.11 11.1 0.0 0.11 11.1 0.0 2.2 2 0 0 2 2 2 0 ArgK protein AAA_16 PF13191.1 CCF42259.1 - 0.95 9.4 4.8 0.64 9.9 0.1 2.6 2 1 0 2 2 2 0 AAA ATPase domain DUF3812 PF12757.2 CCF42261.1 - 4.1e-37 126.9 12.0 4.1e-37 126.9 8.3 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3812) Frag1 PF10277.4 CCF42262.1 - 1.7e-39 135.5 16.4 1.9e-39 135.3 11.4 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family LSM PF01423.17 CCF42263.1 - 6.9e-15 54.3 0.2 9.8e-15 53.8 0.2 1.2 1 0 0 1 1 1 1 LSM domain Ribosomal_L7Ae PF01248.21 CCF42264.1 - 4e-22 77.5 0.4 1.6e-21 75.5 0.3 2.0 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 CCF42264.1 - 0.0096 15.7 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 RNase P subunit Pop3 HK97-gp10_like PF04883.7 CCF42264.1 - 0.11 13.3 0.1 0.11 13.3 0.1 2.4 2 0 0 2 2 2 0 Bacteriophage HK97-gp10, putative tail-component DUF1761 PF08570.5 CCF42265.1 - 7.7e-24 84.1 2.5 8.7e-24 83.9 1.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1761) CBFD_NFYB_HMF PF00808.18 CCF42266.1 - 2.2e-12 46.8 3.0 3.3e-12 46.2 2.1 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 CCF42266.1 - 0.00024 21.1 0.9 0.00039 20.4 0.7 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Pex16 PF08610.5 CCF42266.1 - 7.3 5.4 7.3 14 4.5 5.1 1.4 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) AdoHcyase PF05221.12 CCF42267.1 - 2.7e-137 456.0 0.2 3.2e-137 455.8 0.2 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 CCF42267.1 - 1.5e-83 278.5 2.9 2.3e-83 277.9 2.0 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 CCF42267.1 - 1.1e-06 27.8 0.2 2.9e-06 26.5 0.1 1.7 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.16 CCF42267.1 - 0.0011 18.6 0.1 0.0019 17.8 0.1 1.5 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TrkA_N PF02254.13 CCF42267.1 - 0.005 16.8 0.1 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain IlvN PF07991.7 CCF42267.1 - 0.008 15.5 0.4 0.015 14.6 0.3 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain 3HCDH_N PF02737.13 CCF42267.1 - 0.012 15.3 0.4 0.021 14.4 0.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ig PF00047.20 CCF42267.1 - 0.086 12.9 0.0 10 6.3 0.0 2.7 2 0 0 2 2 2 0 Immunoglobulin domain adh_short PF00106.20 CCF42267.1 - 0.14 12.0 3.6 6.7 6.5 0.0 2.6 2 1 0 2 2 2 0 short chain dehydrogenase zf-C2H2_4 PF13894.1 CCF42268.1 - 0.064 13.6 6.0 0.11 12.8 0.3 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger UBA_4 PF14555.1 CCF42268.1 - 0.16 11.5 0.7 0.89 9.1 0.1 2.3 2 0 0 2 2 2 0 UBA-like domain Peptidase_S8 PF00082.17 CCF42270.1 - 6.5e-28 97.6 0.0 1e-27 97.0 0.0 1.3 1 0 0 1 1 1 1 Subtilase family Ribonuc_L-PSP PF01042.16 CCF42271.1 - 7.4e-12 45.0 0.0 9.2e-12 44.7 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP DDE_1 PF03184.14 CCF42272.1 - 3e-54 183.4 0.0 4e-54 183.0 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 CCF42272.1 - 3e-08 33.5 0.0 8e-08 32.1 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease Clr5 PF14420.1 CCF42274.1 - 1.2e-13 50.6 0.1 3e-13 49.4 0.1 1.7 1 0 0 1 1 1 1 Clr5 domain DUF3965 PF13112.1 CCF42274.1 - 0.17 11.0 0.1 0.27 10.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3965) N2227 PF07942.7 CCF42275.1 - 5.9e-99 330.4 0.0 7.2e-99 330.1 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.1 CCF42275.1 - 0.00027 20.6 0.0 0.00054 19.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF42275.1 - 0.0055 17.1 0.1 0.05 14.0 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF42275.1 - 0.038 14.0 0.3 0.17 11.9 0.2 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.2 CCF42275.1 - 0.056 14.0 0.1 0.62 10.6 0.1 2.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 CCF42275.1 - 0.059 13.8 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Fungal_trans PF04082.13 CCF42277.1 - 2.8e-25 88.6 0.0 5.2e-25 87.8 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF3837 PF12939.2 CCF42277.1 - 0.18 11.8 0.0 1.5 8.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3837) Mito_fiss_reg PF05308.6 CCF42277.1 - 0.92 8.8 6.7 0.58 9.4 3.0 1.7 2 0 0 2 2 2 0 Mitochondrial fission regulator Aldo_ket_red PF00248.16 CCF42278.1 - 2.4e-26 92.1 0.0 2.8e-26 91.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF3435 PF11917.3 CCF42280.1 - 3.4e-109 365.3 0.2 1.8e-108 362.9 0.1 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3435) zf-C2H2 PF00096.21 CCF42280.1 - 3.3 8.2 8.5 0.85 10.0 0.8 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type NOT2_3_5 PF04153.13 CCF42281.1 - 1.7e-41 141.2 8.7 1.7e-41 141.2 6.0 1.9 3 0 0 3 3 3 1 NOT2 / NOT3 / NOT5 family DUF2373 PF10180.4 CCF42281.1 - 0.006 16.0 3.7 0.011 15.2 2.6 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) HUN PF08729.5 CCF42281.1 - 0.053 13.3 1.3 0.1 12.4 0.9 1.5 1 0 0 1 1 1 0 HPC2 and ubinuclein domain Aminotran_3 PF00202.16 CCF42282.1 - 4.3e-05 22.5 0.0 5.2e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III MCM PF00493.18 CCF42283.1 - 1.1e-85 287.3 0.6 1.7e-85 286.7 0.4 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 CCF42283.1 - 1.9e-16 60.6 0.0 3.8e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 CCF42283.1 - 5.1e-08 32.3 0.1 1.1e-06 27.9 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 CCF42283.1 - 0.0023 17.5 0.1 0.006 16.1 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 CCF42283.1 - 0.0044 16.5 0.0 0.015 14.7 0.0 1.8 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_5 PF07728.9 CCF42283.1 - 0.1 12.3 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Peptidase_S28 PF05577.7 CCF42284.1 - 6.3e-47 160.1 0.6 9.9e-47 159.4 0.4 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_6 PF12697.2 CCF42286.1 - 0.0075 16.1 0.0 0.0086 15.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family UPF0149 PF03695.8 CCF42286.1 - 0.04 13.7 0.0 0.05 13.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0149) MFS_1 PF07690.11 CCF42287.1 - 7.2e-29 100.5 17.4 8.5e-29 100.3 12.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF42287.1 - 2.7e-09 36.1 4.3 3.8e-09 35.6 2.5 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter ADH_N PF08240.7 CCF42288.1 - 2.2e-27 94.9 1.8 5e-27 93.8 1.2 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF42288.1 - 7e-21 74.1 1.2 3.5e-20 71.8 0.8 2.0 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ApbA PF02558.11 CCF42288.1 - 0.0074 15.7 0.1 0.013 14.9 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.13 CCF42288.1 - 0.0098 15.8 0.1 0.017 15.1 0.1 1.3 1 0 0 1 1 1 1 TrkA-N domain 3HCDH_N PF02737.13 CCF42288.1 - 0.0098 15.5 0.5 0.016 14.9 0.3 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 CCF42288.1 - 0.015 14.7 0.3 0.032 13.6 0.2 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.15 CCF42288.1 - 0.016 15.2 0.1 0.037 14.1 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Methyltransf_18 PF12847.2 CCF42288.1 - 0.018 15.6 0.2 0.04 14.4 0.1 1.8 1 1 0 1 1 1 0 Methyltransferase domain ThiF PF00899.16 CCF42288.1 - 0.025 14.4 0.8 0.051 13.3 0.5 1.4 1 0 0 1 1 1 0 ThiF family Pyr_redox PF00070.22 CCF42288.1 - 0.036 14.4 0.4 0.2 12.1 0.3 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.16 CCF42288.1 - 0.041 13.4 0.4 0.079 12.5 0.3 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain AdoHcyase_NAD PF00670.16 CCF42288.1 - 0.061 13.1 0.3 0.13 12.0 0.2 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_8 PF13450.1 CCF42288.1 - 0.075 13.0 1.1 0.21 11.6 0.5 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF42288.1 - 0.076 13.0 0.1 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NADH_4Fe-4S PF10589.4 CCF42288.1 - 0.28 10.3 4.9 0.58 9.3 3.4 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region JAB PF01398.16 CCF42289.1 - 1.9e-06 27.6 0.0 5.7e-06 26.0 0.0 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.1 CCF42289.1 - 1.6e-05 24.9 0.1 0.0063 16.5 0.0 2.9 2 1 0 2 2 2 2 Maintenance of mitochondrial structure and function ADH_zinc_N PF00107.21 CCF42292.1 - 2.1e-09 37.0 0.0 4.5e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF42292.1 - 3.9e-08 33.0 0.9 2.4e-07 30.4 0.5 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Glyco_hydro_71 PF03659.9 CCF42294.1 - 3.8e-127 423.9 0.3 4.4e-127 423.7 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 Siah-Interact_N PF09032.6 CCF42294.1 - 0.15 12.1 1.2 0.22 11.5 0.8 1.2 1 0 0 1 1 1 0 Siah interacting protein, N terminal tRNA-synt_2b PF00587.20 CCF42297.1 - 1.5e-20 73.5 0.0 2.5e-20 72.7 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) ProRS-C_1 PF09180.6 CCF42297.1 - 2.2e-19 69.1 1.5 2.4e-19 68.9 0.1 1.8 2 0 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.15 CCF42297.1 - 1.7e-17 63.1 0.0 3.4e-17 62.1 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain Pkinase PF00069.20 CCF42298.1 - 2.1e-49 168.0 0.0 2.7e-46 157.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CCF42298.1 - 2e-29 102.4 0.0 7.5e-28 97.3 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Seadorna_VP7 PF07387.6 CCF42298.1 - 0.00069 18.5 0.1 0.0014 17.5 0.0 1.4 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.1 CCF42298.1 - 0.00085 18.3 0.0 0.0014 17.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pox_ser-thr_kin PF05445.6 CCF42298.1 - 0.36 9.5 0.0 0.54 8.9 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF4252 PF14060.1 CCF42299.1 - 0.0065 16.0 0.5 0.0085 15.6 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4252) CBP4 PF07960.6 CCF42299.1 - 0.098 12.2 4.5 0.057 13.0 2.0 1.4 2 0 0 2 2 2 0 CBP4 DUF4602 PF15375.1 CCF42299.1 - 0.11 12.5 1.2 0.18 11.8 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4602) MFS_1 PF07690.11 CCF42302.1 - 6.2e-42 143.5 50.6 2.5e-41 141.6 31.8 2.6 1 1 1 2 2 2 1 Major Facilitator Superfamily SKG6 PF08693.5 CCF42303.1 - 1.3e-10 40.3 5.8 3e-10 39.2 4.0 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain RCR PF12273.3 CCF42303.1 - 3.5e-05 24.3 5.6 9.4e-05 22.9 3.9 1.7 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red DUF4448 PF14610.1 CCF42303.1 - 0.00071 19.1 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Rifin_STEVOR PF02009.11 CCF42303.1 - 0.093 12.3 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Rifin/stevor family MSP1_C PF07462.6 CCF42303.1 - 5.1 5.3 6.9 7.5 4.8 4.8 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Hexokinase_2 PF03727.11 CCF42304.1 - 2.2e-58 197.3 0.0 8.1e-46 156.1 0.0 2.2 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.16 CCF42304.1 - 3.4e-53 180.0 0.0 5.9e-53 179.2 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Zn_clus PF00172.13 CCF42305.1 - 2.5e-07 30.4 9.2 4.1e-07 29.7 6.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glucosamine_iso PF01182.15 CCF42306.1 - 1.2e-27 96.9 0.0 1.8e-27 96.3 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase FAD_binding_8 PF08022.7 CCF42306.1 - 0.032 14.1 0.0 0.063 13.1 0.0 1.5 1 0 0 1 1 1 0 FAD-binding domain AA_permease_2 PF13520.1 CCF42307.1 - 1e-55 188.9 43.5 1.2e-55 188.7 30.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF42307.1 - 1.2e-23 83.2 36.5 1.5e-23 82.8 25.3 1.0 1 0 0 1 1 1 1 Amino acid permease DUF3040 PF11239.3 CCF42307.1 - 3.5 7.7 6.7 6.6 6.8 0.1 4.3 5 0 0 5 5 5 0 Protein of unknown function (DUF3040) RRM_1 PF00076.17 CCF42309.1 - 1.3e-14 53.5 0.0 3.2e-14 52.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF42309.1 - 1.9e-10 40.5 0.0 3.5e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF42309.1 - 4.5e-07 29.6 0.0 1.1e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 CCF42309.1 - 0.07 12.8 1.5 0.16 11.7 0.0 2.3 2 1 2 4 4 4 0 Limkain b1 CDC27 PF09507.5 CCF42309.1 - 4.7 6.3 36.1 7.4 5.6 25.0 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF935 PF06074.7 CCF42309.1 - 6.7 5.2 13.9 11 4.6 9.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF935) SMN PF06003.7 CCF42310.1 - 5.6e-08 32.2 3.0 1.4e-05 24.3 0.2 2.4 2 1 0 2 2 2 2 Survival motor neuron protein (SMN) F-box-like PF12937.2 CCF42311.1 - 1.2e-10 40.9 0.0 4e-10 39.2 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF42311.1 - 6.6e-08 32.0 0.0 2.6e-07 30.0 0.0 2.1 2 0 0 2 2 2 1 F-box domain LRR_6 PF13516.1 CCF42311.1 - 1.1e-07 31.1 3.0 0.53 10.5 0.0 7.2 7 1 1 8 8 8 2 Leucine Rich repeat LRR_1 PF00560.28 CCF42311.1 - 2.3e-07 29.8 6.0 1.7 8.9 0.0 7.4 6 2 1 7 7 7 2 Leucine Rich Repeat LRR_8 PF13855.1 CCF42311.1 - 5.9e-06 25.9 1.3 0.079 12.7 0.0 4.5 4 1 1 5 5 5 2 Leucine rich repeat LRR_4 PF12799.2 CCF42311.1 - 0.0057 16.2 6.4 0.43 10.2 0.0 5.2 3 2 0 3 3 3 1 Leucine Rich repeats (2 copies) PRANC PF09372.5 CCF42311.1 - 0.17 11.9 0.0 0.55 10.2 0.0 1.9 1 0 0 1 1 1 0 PRANC domain RabGAP-TBC PF00566.13 CCF42312.1 - 1.3e-31 109.7 0.0 5.9e-26 91.2 0.0 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain HET PF06985.6 CCF42313.1 - 4e-23 82.1 0.0 6.6e-23 81.3 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF1264 PF06884.6 CCF42314.1 - 1.3e-59 200.4 0.6 4.4e-59 198.7 0.4 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1264) TMEM240 PF15207.1 CCF42314.1 - 0.15 11.6 0.0 0.29 10.7 0.0 1.4 1 0 0 1 1 1 0 TMEM240 family Helicase_C PF00271.26 CCF42316.1 - 5.2e-13 48.6 0.0 1e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 CCF42316.1 - 6.5e-13 48.1 0.0 1.2e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-RING_5 PF14634.1 CCF42316.1 - 0.00014 21.4 5.5 0.00042 19.9 3.8 1.9 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CCF42316.1 - 0.001 19.0 3.1 0.0021 18.0 1.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CHY PF05495.7 CCF42316.1 - 0.006 16.7 2.5 0.015 15.4 1.7 1.7 1 0 0 1 1 1 1 CHY zinc finger zf-C3HC4 PF00097.20 CCF42316.1 - 0.034 13.8 6.2 0.092 12.4 4.3 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF42316.1 - 0.039 13.6 8.5 0.12 12.0 5.9 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF42316.1 - 0.045 13.5 6.7 0.12 12.2 4.7 1.8 1 0 0 1 1 1 0 Ring finger domain Prok-RING_4 PF14447.1 CCF42316.1 - 0.072 12.6 2.4 0.14 11.7 0.7 2.2 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 DZR PF12773.2 CCF42316.1 - 0.82 9.5 6.0 4.3 7.2 4.1 2.1 1 1 0 1 1 1 0 Double zinc ribbon DDE_1 PF03184.14 CCF42317.1 - 3.4e-23 81.9 0.0 5.1e-23 81.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 CCF42317.1 - 4.6e-10 39.1 0.1 9.7e-10 38.1 0.0 1.6 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain Amidohydro_4 PF13147.1 CCF42320.1 - 3.9e-21 76.3 3.8 5.7e-21 75.7 2.6 1.3 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_5 PF13594.1 CCF42320.1 - 1.6e-06 27.8 0.2 6e-06 25.9 0.0 2.0 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_1 PF01979.15 CCF42320.1 - 2.4e-06 27.4 0.1 3.8e-05 23.4 0.0 2.4 2 1 0 2 2 2 1 Amidohydrolase family Wbp11 PF09429.5 CCF42322.1 - 5.1e-23 80.8 8.9 5.1e-23 80.8 6.2 2.4 2 0 0 2 2 2 1 WW domain binding protein 11 DUF2294 PF10057.4 CCF42322.1 - 0.0034 17.0 0.4 0.0062 16.1 0.3 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2294) Pkinase PF00069.20 CCF42323.1 - 2.8e-58 197.0 0.0 1.7e-57 194.5 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF42323.1 - 6.7e-28 97.4 0.3 1.2e-19 70.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.19 CCF42323.1 - 4.6e-08 33.4 0.4 1.3e-07 32.0 0.3 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 CCF42323.1 - 0.00046 19.2 0.1 0.0027 16.7 0.0 2.2 3 0 0 3 3 3 1 Kinase-like APH PF01636.18 CCF42323.1 - 0.0051 16.5 0.0 0.084 12.5 0.0 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 CCF42323.1 - 0.22 10.3 0.0 0.4 9.4 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 MIF4G PF02854.14 CCF42324.1 - 1.9e-22 79.7 0.8 4.2e-22 78.5 0.0 2.0 3 0 0 3 3 3 1 MIF4G domain MA3 PF02847.12 CCF42324.1 - 3.2e-22 78.3 0.0 1.1e-21 76.6 0.0 2.0 2 0 0 2 2 2 1 MA3 domain ENOD40 PF08247.6 CCF42325.1 - 0.15 11.8 0.7 0.29 10.9 0.5 1.5 1 0 0 1 1 1 0 ENOD40 protein CFEM PF05730.6 CCF42325.1 - 1.5 8.7 16.1 1.5 8.6 10.2 2.0 1 1 0 1 1 1 0 CFEM domain Herpes_capsid PF06112.6 CCF42325.1 - 5.5 7.0 9.9 7.1 6.6 6.9 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Vfa1 PF08432.5 CCF42327.1 - 3.9e-58 196.4 19.7 4.4e-58 196.3 13.7 1.0 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.9 CCF42327.1 - 0.0072 14.4 13.4 0.0083 14.2 9.3 1.0 1 0 0 1 1 1 1 CDC45-like protein GAGA_bind PF06217.7 CCF42327.1 - 0.044 13.7 7.1 0.045 13.7 4.9 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Rtf2 PF04641.7 CCF42327.1 - 0.053 12.7 14.6 0.073 12.2 10.1 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger Ycf1 PF05758.7 CCF42327.1 - 0.19 9.3 13.1 0.21 9.2 9.1 1.0 1 0 0 1 1 1 0 Ycf1 DDHD PF02862.12 CCF42327.1 - 0.24 11.1 3.8 0.32 10.7 2.7 1.2 1 0 0 1 1 1 0 DDHD domain BTV_NS2 PF04514.7 CCF42327.1 - 0.41 9.4 12.6 0.52 9.1 8.7 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 RR_TM4-6 PF06459.7 CCF42327.1 - 0.42 10.4 14.2 0.57 10.0 9.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 UPF0560 PF10577.4 CCF42327.1 - 1.2 7.2 7.3 1.4 7.1 5.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 60KD_IMP PF02096.15 CCF42327.1 - 1.8 8.2 4.1 2.4 7.7 2.9 1.2 1 0 0 1 1 1 0 60Kd inner membrane protein MIP-T3 PF10243.4 CCF42327.1 - 2 6.7 28.8 2.4 6.5 20.0 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 FLO_LFY PF01698.11 CCF42327.1 - 2.6 6.7 12.0 3.7 6.3 8.3 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein DUF1510 PF07423.6 CCF42327.1 - 3.5 6.9 26.4 4.5 6.5 18.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Borrelia_P83 PF05262.6 CCF42327.1 - 5.4 5.1 22.3 6.6 4.8 15.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein SAPS PF04499.10 CCF42327.1 - 6.4 5.3 12.0 7.6 5.0 8.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein U79_P34 PF03064.11 CCF42327.1 - 7.4 6.0 20.8 4.3 6.7 13.3 1.4 2 0 0 2 2 2 0 HSV U79 / HCMV P34 DUF2413 PF10310.4 CCF42327.1 - 9.4 4.9 18.0 12 4.5 12.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Arrestin_N PF00339.24 CCF42328.1 - 3.1e-05 23.8 0.2 0.00022 21.0 0.2 1.9 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Bul1_N PF04425.7 CCF42328.1 - 0.00086 17.9 2.9 0.0036 15.9 0.4 2.0 1 1 0 2 2 2 2 Bul1 N terminus Vps26 PF03643.10 CCF42328.1 - 0.15 10.8 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 26 Ndc80_HEC PF03801.8 CCF42330.1 - 5.5e-64 214.4 0.3 5.5e-64 214.4 0.2 1.8 2 0 0 2 2 2 1 HEC/Ndc80p family AAA_13 PF13166.1 CCF42330.1 - 0.003 16.0 7.3 0.003 16.0 5.1 1.8 2 0 0 2 2 2 1 AAA domain FliJ PF02050.11 CCF42330.1 - 0.017 15.1 20.7 0.039 14.0 0.1 3.0 4 0 0 4 4 2 0 Flagellar FliJ protein NPV_P10 PF05531.7 CCF42330.1 - 0.031 14.5 1.8 2.5 8.4 0.5 3.4 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.7 CCF42330.1 - 0.078 12.7 15.0 0.12 12.1 0.4 4.6 3 1 1 5 5 5 0 Protein of unknown function (DUF1664) Anth_Ig PF05587.8 CCF42330.1 - 0.1 12.4 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Anthrax receptor extracellular domain PEP-utilisers_N PF05524.8 CCF42330.1 - 0.17 11.7 19.0 0.34 10.7 1.2 4.0 2 1 1 4 4 4 0 PEP-utilising enzyme, N-terminal Spc7 PF08317.6 CCF42330.1 - 0.31 9.6 21.2 0.013 14.1 5.9 2.6 3 0 0 3 3 3 0 Spc7 kinetochore protein Tropomyosin_1 PF12718.2 CCF42330.1 - 0.38 10.6 33.1 0.53 10.1 13.3 3.7 2 1 1 3 3 3 0 Tropomyosin like Syntaxin_2 PF14523.1 CCF42330.1 - 0.5 10.4 7.2 0.25 11.3 2.9 2.1 2 0 0 2 2 1 0 Syntaxin-like protein AAA_32 PF13654.1 CCF42330.1 - 0.63 8.6 13.8 2.5 6.6 9.5 1.9 1 1 0 1 1 1 0 AAA domain CCDC155 PF14662.1 CCF42330.1 - 0.65 9.5 25.4 0.12 11.9 13.1 2.8 2 1 0 2 2 2 0 Coiled-coil region of CCDC155 TPR_MLP1_2 PF07926.7 CCF42330.1 - 0.72 9.6 26.8 0.15 11.8 8.1 3.5 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein IncA PF04156.9 CCF42330.1 - 1.2 8.7 28.6 7.5 6.1 0.6 3.5 2 1 0 2 2 2 0 IncA protein GAS PF13851.1 CCF42330.1 - 1.6 7.9 28.6 0.12 11.6 8.5 3.2 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Tropomyosin PF00261.15 CCF42330.1 - 1.9 7.4 37.4 0.23 10.5 8.9 3.2 2 1 1 3 3 3 0 Tropomyosin COG5 PF10392.4 CCF42330.1 - 2.1 8.2 6.9 1.3 8.9 1.5 2.8 3 0 0 3 3 3 0 Golgi transport complex subunit 5 DUF745 PF05335.8 CCF42330.1 - 2.9 7.3 10.9 4.5 6.7 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF745) DivIC PF04977.10 CCF42330.1 - 4 7.0 21.1 2.2 7.8 1.1 4.3 3 1 1 4 4 4 0 Septum formation initiator FlxA PF14282.1 CCF42330.1 - 4 7.4 7.0 18 5.3 0.1 3.2 2 1 1 3 3 3 0 FlxA-like protein Fib_alpha PF08702.5 CCF42330.1 - 6.5 6.8 12.3 9 6.4 0.0 3.9 4 1 0 4 4 3 0 Fibrinogen alpha/beta chain family Kinetocho_Slk19 PF12709.2 CCF42330.1 - 7.7 6.6 19.5 1.9 8.5 0.2 4.3 3 1 1 4 4 4 0 Central kinetochore-associated BLOC1_2 PF10046.4 CCF42330.1 - 9.2 6.4 18.8 1.2 9.3 2.4 4.1 2 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HTH_psq PF05225.11 CCF42331.1 - 5.9e-13 48.1 0.0 1.1e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF42331.1 - 1.2e-09 37.8 0.0 3.1e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.1 CCF42331.1 - 0.00048 19.6 0.2 0.0034 16.9 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain DDE_1 PF03184.14 CCF42331.1 - 0.00089 18.4 0.0 0.0016 17.6 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_28 PF13518.1 CCF42331.1 - 0.041 13.8 0.1 0.1 12.5 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain MARVEL PF01284.18 CCF42332.1 - 0.076 12.8 2.7 0.068 12.9 1.2 1.4 1 1 0 1 1 1 0 Membrane-associating domain DUF998 PF06197.8 CCF42332.1 - 0.11 11.7 5.2 0.42 9.9 3.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF998) 2TM PF13239.1 CCF42332.1 - 0.25 11.4 5.9 0.41 10.7 0.1 2.2 1 1 1 2 2 2 0 2TM domain DUF4231 PF14015.1 CCF42332.1 - 0.31 11.0 4.2 0.71 9.8 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) DUF4064 PF13273.1 CCF42332.1 - 1.4 9.1 8.9 9.3 6.4 5.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) TPR_21 PF09976.4 CCF42333.1 - 0.012 15.5 0.7 0.021 14.7 0.1 1.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 CCF42333.1 - 0.061 12.9 2.2 0.13 11.9 1.5 1.5 1 0 0 1 1 1 0 TPR repeat TPR_12 PF13424.1 CCF42333.1 - 3.3 7.6 7.7 0.52 10.2 2.5 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3425 PF11905.3 CCF42334.1 - 2.8e-28 98.5 0.2 4.1e-28 97.9 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) Aldo_ket_red PF00248.16 CCF42335.1 - 1.6e-62 210.8 0.0 1.8e-62 210.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family AAA PF00004.24 CCF42336.1 - 4.7e-16 59.1 0.0 9.8e-16 58.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CCF42336.1 - 0.00027 20.6 0.0 0.00064 19.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 CCF42336.1 - 0.0016 18.5 0.1 0.0071 16.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CCF42336.1 - 0.0019 17.8 0.1 0.0053 16.4 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 CCF42336.1 - 0.014 15.3 0.0 0.039 13.9 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.1 CCF42336.1 - 0.015 16.1 0.1 0.11 13.3 0.1 2.3 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.1 CCF42336.1 - 0.021 14.7 0.0 0.098 12.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 CCF42336.1 - 0.032 14.5 0.0 0.13 12.5 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 CCF42336.1 - 0.046 13.6 0.0 0.23 11.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain HTH_Tnp_Tc5 PF03221.11 CCF42337.1 - 1.2e-13 50.6 0.1 3.5e-13 49.1 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF42337.1 - 4e-12 45.4 0.1 7.2e-12 44.6 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_28 PF13518.1 CCF42337.1 - 0.00045 20.1 0.4 0.0021 18.0 0.0 2.3 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_23 PF13384.1 CCF42337.1 - 0.00051 19.6 0.6 0.0017 17.9 0.0 2.3 3 0 0 3 3 3 1 Homeodomain-like domain CENP-B_N PF04218.8 CCF42337.1 - 0.011 15.1 0.0 0.019 14.3 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_29 PF13551.1 CCF42337.1 - 0.041 14.0 1.3 0.12 12.5 0.4 2.1 1 1 1 2 2 2 0 Winged helix-turn helix HTH_8 PF02954.14 CCF42337.1 - 0.089 12.3 0.3 0.5 9.9 0.0 2.4 1 1 1 2 2 2 0 Bacterial regulatory protein, Fis family DUF1399 PF07173.7 CCF42338.1 - 1.2e-16 61.2 0.1 2.4e-16 60.2 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1399) ABC_tran PF00005.22 CCF42341.1 - 8.5e-26 90.8 0.0 3.5e-25 88.8 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.1 CCF42341.1 - 2.5e-09 37.5 0.0 2.1e-08 34.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain hEGF PF12661.2 CCF42341.1 - 5.3e-05 23.0 21.2 0.0039 17.1 2.1 4.3 3 0 0 3 3 3 2 Human growth factor-like EGF AAA_25 PF13481.1 CCF42341.1 - 8.4e-05 22.0 0.0 0.005 16.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 CCF42341.1 - 0.0018 17.7 0.0 0.0044 16.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 CCF42341.1 - 0.0046 16.1 0.0 0.012 14.7 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF258 SMC_N PF02463.14 CCF42341.1 - 0.0062 15.7 0.0 0.17 11.0 0.0 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 CCF42341.1 - 0.028 13.4 0.0 1.3 7.9 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.1 CCF42341.1 - 0.028 14.5 0.0 0.085 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CCF42341.1 - 0.029 14.6 0.0 0.076 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 CCF42341.1 - 0.046 13.3 0.0 0.088 12.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_23 PF13476.1 CCF42341.1 - 0.05 13.9 0.1 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 CCF42341.1 - 0.062 14.1 0.0 0.14 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CCF42341.1 - 0.064 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain cobW PF02492.14 CCF42341.1 - 0.082 12.3 0.1 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 CCF42341.1 - 0.11 12.4 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 CCF42341.1 - 0.13 12.1 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 CCF42341.1 - 0.15 11.7 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase AAA_28 PF13521.1 CCF42341.1 - 0.16 11.9 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain bZIP_1 PF00170.16 CCF42343.1 - 1.1e-05 25.2 7.6 1.1e-05 25.2 5.3 1.7 2 0 0 2 2 2 1 bZIP transcription factor DUF4407 PF14362.1 CCF42343.1 - 1.2 8.0 4.5 1.9 7.3 3.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) bZIP_2 PF07716.10 CCF42343.1 - 4.4 7.2 11.0 0.86 9.4 4.6 2.0 2 0 0 2 2 2 0 Basic region leucine zipper Pro-kuma_activ PF09286.6 CCF42344.1 - 4.7e-35 120.7 0.0 1e-34 119.6 0.0 1.6 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 CCF42344.1 - 1.7e-08 33.9 0.2 2.7e-08 33.3 0.1 1.3 1 0 0 1 1 1 1 Subtilase family DUF3716 PF12511.3 CCF42348.1 - 8.5e-10 38.0 1.2 1.1e-09 37.6 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) DHquinase_I PF01487.10 CCF42349.1 - 3.6e-56 190.3 0.0 5.5e-56 189.7 0.0 1.3 1 0 0 1 1 1 1 Type I 3-dehydroquinase Cu_amine_oxid PF01179.15 CCF42351.1 - 8.4e-162 538.5 0.0 1e-161 538.3 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.11 CCF42351.1 - 1.3e-09 38.0 0.1 3.8e-09 36.4 0.0 1.8 2 0 0 2 2 2 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.11 CCF42351.1 - 6e-06 26.2 0.0 1.8e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Mit_proteolip PF08039.6 CCF42353.1 - 0.099 12.6 0.3 0.16 11.9 0.2 1.3 1 0 0 1 1 1 0 Mitochondrial proteolipid DUF3328 PF11807.3 CCF42354.1 - 9.8e-32 110.3 0.2 1.3e-31 109.9 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) adh_short PF00106.20 CCF42355.1 - 2.4e-23 82.8 2.0 3.5e-23 82.3 1.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF42355.1 - 5.6e-16 59.0 0.0 7.1e-16 58.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF42355.1 - 8.3e-08 32.0 0.9 1.3e-07 31.4 0.6 1.2 1 0 0 1 1 1 1 KR domain TPR_14 PF13428.1 CCF42357.1 - 8.5e-07 29.0 0.0 0.0041 17.6 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 CCF42357.1 - 2.1e-06 27.1 0.3 0.0051 16.6 0.1 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 CCF42357.1 - 4e-06 27.0 0.0 0.00045 20.4 0.0 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 CCF42357.1 - 1.3e-05 25.7 0.3 0.021 15.5 0.4 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 CCF42357.1 - 2.1e-05 23.9 0.0 0.00059 19.4 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 CCF42357.1 - 0.00011 22.1 0.1 0.0026 17.8 0.0 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 CCF42357.1 - 0.00015 21.2 0.0 0.61 9.7 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 CCF42357.1 - 0.00022 20.8 0.0 0.13 11.9 0.0 2.3 2 0 0 2 2 2 2 TPR repeat TPR_7 PF13176.1 CCF42357.1 - 0.0051 16.5 0.1 0.59 10.0 0.0 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 CCF42357.1 - 0.012 15.5 0.0 1 9.3 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_21 PF09976.4 CCF42357.1 - 0.097 12.6 0.2 0.75 9.7 0.1 2.3 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 CCF42357.1 - 0.11 13.0 0.0 1.2 9.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat NAPRTase PF04095.11 CCF42359.1 - 5.4e-31 107.7 0.0 9.9e-31 106.8 0.0 1.4 1 1 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family DUF3812 PF12757.2 CCF42360.1 - 4.4e-37 126.8 11.5 4.4e-37 126.8 8.0 4.3 3 2 1 4 4 4 1 Protein of unknown function (DUF3812) Peptidase_S8 PF00082.17 CCF42361.1 - 0.0015 17.7 0.1 0.0017 17.5 0.1 1.2 1 0 0 1 1 1 1 Subtilase family p450 PF00067.17 CCF42363.1 - 2.9e-33 115.0 0.0 3.7e-33 114.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Amidohydro_1 PF01979.15 CCF42365.1 - 1.2e-26 94.1 0.1 1.6e-26 93.7 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 CCF42365.1 - 3.5e-12 46.9 0.6 3.2e-05 24.1 0.0 2.4 2 1 0 2 2 2 2 Amidohydrolase Amidohydro_5 PF13594.1 CCF42365.1 - 1.4e-06 28.0 0.1 0.00015 21.5 0.0 3.0 3 0 0 3 3 3 1 Amidohydrolase Amidohydro_3 PF07969.6 CCF42365.1 - 8e-06 25.3 1.0 0.00019 20.8 0.2 2.4 2 1 0 2 2 2 1 Amidohydrolase family DUF3775 PF12616.3 CCF42365.1 - 0.16 11.7 0.0 0.44 10.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3775) adh_short PF00106.20 CCF42366.1 - 3.9e-31 108.2 4.5 4.9e-31 107.8 3.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF42366.1 - 6.1e-23 81.8 0.1 7.8e-23 81.4 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF42366.1 - 1.2e-11 44.6 2.0 1.8e-11 44.0 1.4 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF42366.1 - 0.087 12.2 0.4 0.77 9.1 0.3 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.13 CCF42366.1 - 0.09 12.4 0.2 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Delta_lysin PF05372.6 CCF42366.1 - 0.095 12.0 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 Delta lysin family Ammonium_transp PF00909.16 CCF42367.1 - 4.9e-118 394.0 30.5 5.6e-118 393.8 21.2 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family ABC_membrane PF00664.18 CCF42367.1 - 0.68 9.2 10.8 0.98 8.7 0.1 3.0 3 0 0 3 3 3 0 ABC transporter transmembrane region CcmD PF04995.9 CCF42368.1 - 3.2 7.5 4.7 0.84 9.4 0.3 2.1 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) Glyco_hydro_43 PF04616.9 CCF42369.1 - 6.7e-26 91.0 0.0 8e-26 90.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GMC_oxred_C PF05199.8 CCF42370.1 - 1.3e-09 38.4 0.3 3.4e-09 37.1 0.2 1.7 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.14 CCF42370.1 - 0.0001 21.5 0.0 0.0013 18.0 0.0 2.5 1 1 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.1 CCF42370.1 - 0.0051 16.8 0.2 0.02 14.8 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF42370.1 - 0.046 12.6 0.2 0.17 10.7 0.0 2.0 3 0 0 3 3 3 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF42370.1 - 0.09 12.6 1.7 0.14 12.0 0.0 2.2 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_2_C PF02836.12 CCF42371.1 - 2.6e-23 82.3 0.0 3e-23 82.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_cc PF11790.3 CCF42371.1 - 0.0043 16.5 0.0 0.0048 16.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_53 PF07745.8 CCF42371.1 - 0.01 14.6 0.0 0.01 14.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 Phage_antiter_Q PF06323.6 CCF42371.1 - 0.04 13.2 0.0 0.065 12.6 0.0 1.3 1 0 0 1 1 1 0 Phage antitermination protein Q Pkinase PF00069.20 CCF42372.1 - 1.2e-16 60.6 0.0 3e-16 59.3 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF42372.1 - 0.00066 18.8 0.0 0.0012 18.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF387 PF04079.11 CCF42373.1 - 0.035 13.4 0.6 0.61 9.4 0.3 2.6 2 0 0 2 2 2 0 Putative transcriptional regulators (Ypuh-like) MFS_1 PF07690.11 CCF42374.1 - 2.1e-14 53.0 34.1 2.1e-14 53.0 23.6 2.3 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF1049 PF06305.6 CCF42374.1 - 0.032 13.6 1.1 0.032 13.6 0.7 3.9 5 0 0 5 5 5 0 Protein of unknown function (DUF1049) DUF2368 PF10166.4 CCF42374.1 - 0.11 12.1 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) Claudin_3 PF06653.6 CCF42375.1 - 0.087 12.5 0.0 0.093 12.4 0.0 1.0 1 0 0 1 1 1 0 Tight junction protein, Claudin-like ODV-E18 PF10717.4 CCF42376.1 - 0.039 13.3 0.1 0.058 12.8 0.1 1.3 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Met_10 PF02475.11 CCF42377.1 - 8.1e-72 241.0 0.0 1.3e-71 240.3 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_18 PF12847.2 CCF42377.1 - 0.041 14.4 0.0 0.11 13.0 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain TRM PF02005.11 CCF42377.1 - 0.12 11.3 0.0 0.22 10.3 0.0 1.4 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase 2OG-FeII_Oxy_2 PF13532.1 CCF42378.1 - 8.4e-29 100.7 0.0 1.2e-28 100.3 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 CCF42378.1 - 1.3e-06 28.6 0.0 2.7e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Prenyltransf PF01255.14 CCF42379.1 - 1e-05 24.7 0.0 0.00013 21.1 0.0 2.0 2 0 0 2 2 2 1 Putative undecaprenyl diphosphate synthase Ald_Xan_dh_C2 PF02738.13 CCF42379.1 - 0.22 9.8 0.0 0.3 9.3 0.0 1.1 1 0 0 1 1 1 0 Molybdopterin-binding domain of aldehyde dehydrogenase OCD_Mu_crystall PF02423.10 CCF42381.1 - 0.00087 18.1 0.0 0.022 13.5 0.0 2.1 1 1 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Formyl_trans_N PF00551.14 CCF42382.1 - 1.9e-37 128.6 0.0 2.2e-37 128.3 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase MannoseP_isomer PF01050.13 CCF42382.1 - 0.02 14.4 0.2 0.038 13.5 0.0 1.5 2 0 0 2 2 2 0 Mannose-6-phosphate isomerase Gar1 PF04410.9 CCF42382.1 - 0.055 12.9 0.1 0.094 12.1 0.1 1.3 1 0 0 1 1 1 0 Gar1/Naf1 RNA binding region Cation_efflux PF01545.16 CCF42383.1 - 4.3e-34 117.8 11.5 6.3e-34 117.3 8.0 1.2 1 0 0 1 1 1 1 Cation efflux family PI3_PI4_kinase PF00454.22 CCF42384.1 - 8.2e-41 140.0 0.0 2.5e-40 138.4 0.0 1.8 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 CCF42384.1 - 1.7e-22 79.5 0.0 4.4e-22 78.1 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Flu_NS2 PF00601.14 CCF42384.1 - 0.028 14.6 0.4 2.4 8.3 0.0 3.0 2 0 0 2 2 2 0 Influenza non-structural protein (NS2) Proteasome PF00227.21 CCF42385.1 - 5.4e-27 94.3 0.3 1.9e-26 92.5 0.1 1.8 2 1 0 2 2 2 1 Proteasome subunit Sec63 PF02889.11 CCF42386.1 - 9.5e-98 327.2 0.0 1.3e-97 326.8 0.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.24 CCF42386.1 - 2.9e-26 91.9 0.3 1.3e-13 50.8 0.2 3.6 4 0 0 4 4 4 2 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF42386.1 - 8.2e-08 32.0 0.0 7.4e-06 25.7 0.0 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF42386.1 - 2e-07 31.0 0.0 0.0089 15.8 0.0 2.8 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_19 PF13245.1 CCF42386.1 - 0.0017 18.0 0.1 0.015 15.0 0.0 2.4 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 CCF42386.1 - 0.037 14.1 0.1 3.1 7.9 0.0 2.9 2 0 0 2 2 2 0 AAA domain Peptidase_S8 PF00082.17 CCF42387.1 - 6.3e-15 55.0 0.0 9.4e-15 54.4 0.0 1.2 1 0 0 1 1 1 1 Subtilase family PAN_4 PF14295.1 CCF42387.1 - 0.028 14.1 0.4 0.083 12.6 0.3 1.8 1 0 0 1 1 1 0 PAN domain UxuA PF03786.8 CCF42387.1 - 0.16 10.5 0.0 0.25 9.8 0.0 1.2 1 0 0 1 1 1 0 D-mannonate dehydratase (UxuA) FAD_binding_4 PF01565.18 CCF42390.1 - 8.6e-20 70.6 2.0 8.6e-20 70.6 1.4 1.6 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.7 CCF42390.1 - 0.00037 20.3 0.2 0.00089 19.1 0.2 1.6 1 0 0 1 1 1 1 Berberine and berberine like GMC_oxred_N PF00732.14 CCF42393.1 - 8.6e-54 182.6 0.0 1.1e-53 182.3 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF42393.1 - 3.4e-39 134.4 0.0 5.2e-39 133.8 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 CCF42393.1 - 1.7e-07 30.4 0.1 0.011 14.6 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 CCF42393.1 - 1.1e-06 27.7 0.0 8.7e-05 21.5 0.0 2.5 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF42393.1 - 2e-05 24.4 0.1 0.00019 21.3 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 CCF42393.1 - 2.4e-05 23.4 0.0 3.7e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Trp_halogenase PF04820.9 CCF42393.1 - 0.004 15.8 0.2 0.0091 14.6 0.0 1.6 2 0 0 2 2 2 1 Tryptophan halogenase FAD_oxidored PF12831.2 CCF42393.1 - 0.0084 15.2 0.2 0.87 8.5 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF42393.1 - 0.013 15.3 0.0 0.03 14.2 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF42393.1 - 0.021 15.2 0.2 0.17 12.3 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF42393.1 - 0.078 11.4 0.0 0.13 10.7 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_3 PF13738.1 CCF42393.1 - 0.11 12.5 0.0 14 5.6 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF42393.1 - 0.12 12.1 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding NOSIC PF08060.8 CCF42395.1 - 0.052 13.3 0.0 0.14 11.9 0.0 1.7 2 0 0 2 2 2 0 NOSIC (NUC001) domain Methyltransf_23 PF13489.1 CCF42396.1 - 4.3e-13 49.2 0.1 8.6e-13 48.3 0.0 1.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF42396.1 - 1.8e-07 31.5 0.0 3.4e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF42396.1 - 3e-07 31.0 0.0 1.4e-06 28.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF42396.1 - 1.5e-05 24.6 0.0 6.8e-05 22.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF42396.1 - 0.00064 20.1 0.0 0.012 16.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain CheR PF01739.13 CCF42396.1 - 0.0042 16.3 0.0 0.0066 15.7 0.0 1.2 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_4 PF02390.12 CCF42396.1 - 0.11 11.5 0.0 1.2 8.1 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase IF4E PF01652.13 CCF42397.1 - 3.5e-42 143.7 0.1 4.4e-42 143.4 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E CBM_20 PF00686.14 CCF42397.1 - 0.12 11.9 0.3 2.2 7.9 0.0 2.2 2 0 0 2 2 2 0 Starch binding domain UCH PF00443.24 CCF42398.1 - 4e-25 88.4 0.0 6e-25 87.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 CCF42398.1 - 7.2e-12 45.2 0.3 7.2e-12 45.2 0.2 1.9 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.1 CCF42398.1 - 0.0095 15.4 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.27 CCF42399.1 - 5.5e-68 222.6 18.0 1.6e-09 37.3 0.0 11.8 11 0 0 11 11 11 10 WD domain, G-beta repeat Utp13 PF08625.6 CCF42399.1 - 4.5e-43 146.2 0.2 6.8e-43 145.6 0.2 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain Nup160 PF11715.3 CCF42399.1 - 7.6e-08 30.9 1.9 0.00016 19.9 0.1 4.4 3 2 0 4 4 4 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 CCF42399.1 - 1.3e-05 24.1 1.0 0.46 9.1 0.0 4.9 6 0 0 6 6 6 2 Nup133 N terminal like CENP-S PF15630.1 CCF42401.1 - 2.1e-35 120.7 0.0 2.9e-35 120.2 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S Bromo_TP PF07524.8 CCF42401.1 - 0.00046 19.8 0.0 0.0024 17.5 0.0 1.9 1 1 0 1 1 1 1 Bromodomain associated Histone PF00125.19 CCF42401.1 - 0.0036 17.3 0.0 0.0047 17.0 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.11 CCF42401.1 - 0.013 15.2 0.1 0.018 14.8 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit CENP-T PF15511.1 CCF42401.1 - 0.018 14.3 0.1 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T TAF PF02969.12 CCF42401.1 - 0.046 13.6 0.0 0.095 12.6 0.0 1.5 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) TFIID-31kDa PF02291.10 CCF42401.1 - 0.068 12.9 0.0 0.08 12.7 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Catalase-rel PF06628.7 CCF42401.1 - 0.099 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Catalase-related immune-responsive PGA2 PF07543.7 CCF42402.1 - 3e-37 127.5 0.3 3.4e-37 127.3 0.2 1.0 1 0 0 1 1 1 1 Protein trafficking PGA2 COMPASS-Shg1 PF05205.7 CCF42403.1 - 7.3e-27 93.7 0.4 7.3e-27 93.7 0.3 1.9 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component shg1 Asp-B-Hydro_N PF05279.6 CCF42403.1 - 0.8 9.5 20.9 1.1 9.0 14.5 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Nop53 PF07767.6 CCF42403.1 - 2.5 6.9 26.5 3.3 6.5 18.4 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Ycf1 PF05758.7 CCF42403.1 - 3.4 5.2 7.8 3.3 5.3 5.4 1.1 1 0 0 1 1 1 0 Ycf1 p450 PF00067.17 CCF42404.1 - 3.6e-13 48.8 0.0 4e-13 48.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3661 PF12400.3 CCF42405.1 - 7.1e-20 71.4 3.9 8.7e-20 71.1 2.7 1.1 1 0 0 1 1 1 1 Vaculolar membrane protein Hid1 PF12722.2 CCF42407.1 - 0.019 12.6 0.0 0.02 12.6 0.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein E1-E2_ATPase PF00122.15 CCF42409.1 - 1e-15 57.4 0.0 1.9e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_like2 PF13246.1 CCF42409.1 - 7.2e-05 22.6 0.0 0.00016 21.5 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit p450 PF00067.17 CCF42410.1 - 3.9e-61 206.9 0.0 4.6e-61 206.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Zn_clus PF00172.13 CCF42411.1 - 3.9e-08 33.0 8.0 5.8e-08 32.5 5.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF42411.1 - 0.0011 17.6 0.1 0.0014 17.2 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Bax1-I PF01027.15 CCF42413.1 - 5.2e-49 166.6 27.1 6e-49 166.4 18.8 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Spore_YhaL PF14147.1 CCF42413.1 - 0.14 11.5 0.8 0.43 10.0 0.1 2.2 2 0 0 2 2 2 0 Sporulation protein YhaL DUF2157 PF09925.4 CCF42413.1 - 0.93 9.0 12.8 0.048 13.2 4.4 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) MBOAT_2 PF13813.1 CCF42414.1 - 4e-12 46.0 4.5 4e-12 46.0 3.1 2.8 3 0 0 3 3 3 1 Membrane bound O-acyl transferase family MAP65_ASE1 PF03999.7 CCF42415.1 - 3.3e-71 240.7 22.4 3.3e-71 240.7 15.5 2.8 2 1 0 2 2 2 1 Microtubule associated protein (MAP65/ASE1 family) LemA PF04011.7 CCF42415.1 - 0.053 12.6 0.1 0.19 10.7 0.0 1.9 1 0 0 1 1 1 0 LemA family DUF948 PF06103.6 CCF42415.1 - 1.8 8.4 5.7 3.1 7.6 0.3 3.5 6 0 0 6 6 6 0 Bacterial protein of unknown function (DUF948) Pyr_redox_3 PF13738.1 CCF42416.1 - 6.3e-25 88.4 0.3 2e-24 86.7 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF42416.1 - 6.2e-06 26.1 0.6 6.2e-06 26.1 0.4 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 CCF42416.1 - 5.8e-05 22.9 0.0 0.003 17.3 0.1 2.6 3 0 0 3 3 3 1 FAD-NAD(P)-binding 2-Hacid_dh_C PF02826.14 CCF42416.1 - 0.00056 19.1 0.0 0.0039 16.3 0.0 2.1 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 CCF42416.1 - 0.0012 18.9 0.0 0.2 11.7 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.9 CCF42416.1 - 0.0023 17.8 0.0 0.039 13.8 0.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF42416.1 - 0.0038 16.1 0.0 0.0064 15.4 0.0 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) ThiF PF00899.16 CCF42416.1 - 0.09 12.6 2.4 11 5.7 0.7 2.6 2 0 0 2 2 2 0 ThiF family Malic_M PF03949.10 CCF42416.1 - 0.13 11.8 0.1 13 5.2 0.1 2.2 2 0 0 2 2 2 0 Malic enzyme, NAD binding domain Rop-like PF05082.8 CCF42416.1 - 0.15 11.5 0.0 1.5 8.3 0.0 2.2 2 0 0 2 2 2 0 Rop-like DAO PF01266.19 CCF42416.1 - 0.98 8.2 7.8 0.1 11.4 1.8 2.0 2 1 0 2 2 2 0 FAD dependent oxidoreductase polyprenyl_synt PF00348.12 CCF42417.1 - 4e-51 173.3 0.0 5.1e-51 173.0 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase adh_short PF00106.20 CCF42418.1 - 3.1e-19 69.4 0.1 6.2e-19 68.5 0.1 1.5 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF42418.1 - 6e-10 39.3 0.0 1.2e-09 38.3 0.0 1.4 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF42418.1 - 4.5e-08 32.9 0.1 7.8e-08 32.1 0.1 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF42418.1 - 0.00022 21.3 0.7 0.00074 19.5 0.5 2.0 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF42418.1 - 0.00028 20.4 0.0 0.00039 19.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.15 CCF42418.1 - 0.034 14.2 0.0 0.06 13.4 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 CCF42418.1 - 0.085 13.1 0.0 0.29 11.4 0.0 1.9 2 1 0 2 2 2 0 Putative NAD(P)-binding UbiA PF01040.13 CCF42419.1 - 4.6e-29 101.4 12.4 5.8e-29 101.0 8.6 1.0 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF4293 PF14126.1 CCF42419.1 - 1.2 9.0 4.7 3.9 7.3 0.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) Sugar_tr PF00083.19 CCF42422.1 - 3.9e-07 28.9 5.9 4.8e-07 28.7 4.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF42422.1 - 6.5e-07 28.3 8.9 9.6e-07 27.8 6.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF308 PF03729.8 CCF42422.1 - 1.6 8.7 12.2 2.3 8.2 3.2 2.2 1 1 1 2 2 2 0 Short repeat of unknown function (DUF308) RNA_POL_M_15KD PF02150.11 CCF42424.1 - 2.4e-11 43.1 2.8 2.4e-11 43.1 2.0 2.2 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit GFA PF04828.9 CCF42424.1 - 0.26 11.2 8.8 0.21 11.5 0.4 2.3 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zf-NADH-PPase PF09297.6 CCF42424.1 - 0.3 10.6 3.9 13 5.4 0.0 2.6 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain IBR PF01485.16 CCF42424.1 - 0.36 10.7 10.0 40 4.1 7.0 2.3 1 1 0 1 1 1 0 IBR domain DZR PF12773.2 CCF42424.1 - 0.61 9.9 13.8 0.12 12.2 2.5 2.7 2 1 0 2 2 2 0 Double zinc ribbon zf-C3HC4_3 PF13920.1 CCF42424.1 - 6.1 6.6 15.0 0.11 12.1 1.8 2.8 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Rotamase PF00639.16 CCF42425.1 - 8.5e-23 80.9 0.1 1.3e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 CCF42425.1 - 1.3e-16 60.9 0.0 1.7e-16 60.5 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.21 CCF42425.1 - 1.8e-08 34.0 0.2 3.8e-08 33.0 0.2 1.6 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.1 CCF42425.1 - 3.4e-06 27.7 0.0 5.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain MAM PF00629.18 CCF42425.1 - 0.15 11.7 0.5 1.2 8.8 0.0 1.9 1 1 1 2 2 2 0 MAM domain MbtH PF03621.8 CCF42425.1 - 0.24 10.8 0.9 14 5.1 0.0 2.7 3 0 0 3 3 3 0 MbtH-like protein FBPase PF00316.15 CCF42427.1 - 2.3e-08 33.2 0.0 4.9e-08 32.1 0.0 1.4 1 1 1 2 2 2 1 Fructose-1-6-bisphosphatase Pkinase PF00069.20 CCF42428.1 - 1.2e-26 93.4 0.0 1.9e-26 92.7 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF42428.1 - 0.0034 16.5 0.0 0.031 13.3 0.0 2.4 3 1 0 3 3 3 1 Protein tyrosine kinase RPE65 PF03055.10 CCF42429.1 - 7.1e-91 305.1 0.0 8.7e-91 304.8 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Peptidase_S28 PF05577.7 CCF42430.1 - 3.4e-06 25.9 0.0 4e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 ETC_C1_NDUFA4 PF04800.7 CCF42430.1 - 0.065 13.0 0.1 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 ETC complex I subunit conserved region Glyco_transf_8 PF01501.15 CCF42431.1 - 5.3e-38 130.7 0.0 9.9e-38 129.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.3 CCF42431.1 - 0.0011 18.4 0.0 0.0019 17.6 0.0 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative zf-rbx1 PF12678.2 CCF42432.1 - 1e-11 44.7 1.2 1.9e-11 43.8 0.8 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 CCF42432.1 - 1.7e-11 43.7 4.7 3.1e-11 42.9 3.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 CCF42432.1 - 4.6e-07 29.4 4.3 1.7e-06 27.5 3.1 1.8 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CCF42432.1 - 3.6e-06 26.8 2.5 9.6e-06 25.5 1.7 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF42432.1 - 4.3e-06 26.3 2.4 7.6e-06 25.5 1.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 CCF42432.1 - 5.1e-06 26.0 3.4 9e-06 25.2 2.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 CCF42432.1 - 0.00075 19.1 3.5 0.0019 17.8 2.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-Apc11 PF12861.2 CCF42432.1 - 0.0025 17.6 2.4 0.0062 16.3 1.7 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.3 CCF42432.1 - 0.095 12.6 2.3 0.35 10.8 1.6 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.1 CCF42432.1 - 0.1 12.5 1.4 0.22 11.4 1.0 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.1 CCF42432.1 - 0.92 9.1 2.8 2.1 8.0 2.0 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain CMD PF02627.15 CCF42433.1 - 0.00036 20.3 0.0 0.00045 20.0 0.0 1.2 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family MFS_1 PF07690.11 CCF42434.1 - 3.9e-19 68.5 49.9 2.1e-17 62.9 25.3 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Zn_clus PF00172.13 CCF42435.1 - 1.7e-08 34.2 10.1 1.7e-08 34.2 7.0 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cu_amine_oxidN2 PF02727.11 CCF42436.1 - 2.2e-11 43.6 0.0 4.1e-11 42.7 0.0 1.5 2 0 0 2 2 2 1 Copper amine oxidase, N2 domain DUF1454 PF07305.7 CCF42437.1 - 0.077 12.0 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1454) Cyclin_N PF00134.18 CCF42438.1 - 7e-08 32.0 0.2 8.1e-08 31.8 0.1 1.1 1 0 0 1 1 1 1 Cyclin, N-terminal domain Mito_carr PF00153.22 CCF42439.1 - 4.8e-07 29.3 0.0 1.3e-06 27.9 0.0 1.7 1 1 0 1 1 1 1 Mitochondrial carrier protein SID-1_RNA_chan PF13965.1 CCF42440.1 - 0.12 10.5 5.7 0.18 9.9 4.0 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Aldolase_II PF00596.16 CCF42442.1 - 2.3e-40 138.1 0.0 2.8e-40 137.8 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain DUF647 PF04884.9 CCF42443.1 - 7e-91 303.8 0.7 9.3e-91 303.4 0.5 1.2 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis Ribosomal_S3Ae PF01015.13 CCF42444.1 - 5.1e-77 257.6 2.9 6.3e-77 257.3 2.0 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Syntaxin PF00804.20 CCF42444.1 - 0.054 13.6 0.1 0.17 12.0 0.0 1.8 1 1 1 2 2 2 0 Syntaxin Abhydro_lipase PF04083.11 CCF42444.1 - 0.14 11.5 0.0 0.28 10.5 0.0 1.5 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region SGL PF08450.7 CCF42445.1 - 0.0004 19.8 0.1 0.02 14.2 0.0 2.4 1 1 1 2 2 2 1 SMP-30/Gluconolaconase/LRE-like region NHL PF01436.16 CCF42445.1 - 0.01 15.7 0.6 0.24 11.4 0.0 3.4 4 0 0 4 4 4 0 NHL repeat PD40 PF07676.7 CCF42445.1 - 0.012 15.2 0.1 0.046 13.4 0.1 2.1 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat Arylesterase PF01731.15 CCF42445.1 - 0.059 13.3 0.0 1.3 9.0 0.0 2.9 3 0 0 3 3 3 0 Arylesterase Aldo_ket_red PF00248.16 CCF42446.1 - 7e-56 189.1 0.0 8.7e-56 188.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HgmA PF04209.8 CCF42448.1 - 5.8e-52 176.5 0.0 6.8e-52 176.2 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase EF-hand_1 PF00036.27 CCF42449.1 - 4.3e-26 88.1 13.5 4.9e-07 28.5 0.6 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 CCF42449.1 - 2e-23 82.2 3.7 1.2e-12 47.7 0.6 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 CCF42449.1 - 5.2e-20 69.4 6.3 4.7e-05 22.9 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 CCF42449.1 - 3.4e-18 64.0 13.2 2.2e-06 26.7 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 CCF42449.1 - 4.6e-15 54.9 13.3 2.3e-05 23.9 0.8 4.5 1 1 3 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 CCF42449.1 - 5e-07 29.7 0.0 0.00028 20.8 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 CCF42449.1 - 4.1e-06 26.4 8.2 0.0028 17.3 0.4 3.8 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 CCF42449.1 - 0.039 13.8 0.1 1.7 8.5 0.0 3.0 2 1 1 3 3 3 0 EF-hand domain SNF5 PF04855.7 CCF42450.1 - 5.3e-75 252.0 0.0 7.9e-75 251.4 0.0 1.2 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 ORC5_C PF14630.1 CCF42454.1 - 7.7e-48 163.2 0.0 8.5e-48 163.1 0.0 1.0 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus TPT PF03151.11 CCF42455.1 - 1.1e-39 135.4 2.2 1.1e-39 135.4 1.5 2.1 2 0 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 CCF42455.1 - 1.1e-09 37.6 12.9 3.4e-09 36.0 8.9 1.7 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 CCF42455.1 - 8.5e-08 32.2 28.7 0.00071 19.6 7.1 3.2 2 1 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.10 CCF42455.1 - 0.0034 16.5 1.1 0.43 9.6 0.0 2.5 2 1 0 2 2 2 2 Nucleotide-sugar transporter Multi_Drug_Res PF00893.14 CCF42455.1 - 3.4 8.1 10.5 2.5 8.6 0.3 3.7 3 1 1 4 4 4 0 Small Multidrug Resistance protein Metallophos PF00149.23 CCF42456.1 - 1.7e-38 132.0 0.2 2.1e-38 131.7 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Dus PF01207.12 CCF42457.1 - 1.8e-35 122.2 0.0 9.9e-26 90.2 0.0 2.6 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH PF00642.19 CCF42457.1 - 0.88 9.3 9.4 0.88 9.3 0.1 2.8 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Bap31 PF05529.7 CCF42458.1 - 5.1e-66 221.8 4.5 5.9e-66 221.6 3.1 1.0 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like TMF_DNA_bd PF12329.3 CCF42458.1 - 0.0031 17.2 3.4 0.0056 16.4 2.4 1.5 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding DUF192 PF02643.10 CCF42458.1 - 0.0032 17.1 0.0 0.006 16.2 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized ACR, COG1430 Lge1 PF11488.3 CCF42458.1 - 0.013 15.6 0.4 0.025 14.7 0.3 1.5 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 Phage_GP20 PF06810.6 CCF42458.1 - 0.074 12.4 4.5 0.12 11.8 3.1 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 DivIC PF04977.10 CCF42458.1 - 0.088 12.2 5.5 0.14 11.7 0.6 2.9 2 1 1 3 3 3 0 Septum formation initiator Spc24 PF08286.6 CCF42458.1 - 0.11 12.2 0.8 0.2 11.3 0.6 1.5 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 IncA PF04156.9 CCF42458.1 - 0.12 11.9 1.9 0.19 11.3 1.3 1.3 1 0 0 1 1 1 0 IncA protein DUF4446 PF14584.1 CCF42458.1 - 0.13 12.0 2.3 0.16 11.7 0.2 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF4446) DUF2956 PF11169.3 CCF42458.1 - 0.39 10.6 6.6 0.8 9.6 4.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) Peroxin-13_N PF04088.8 CCF42459.1 - 2.2e-58 196.7 0.0 3.4e-58 196.0 0.0 1.3 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.12 CCF42459.1 - 2.5e-09 36.4 0.0 4.1e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 CCF42459.1 - 1.7e-07 30.4 0.0 3.5e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 CCF42459.1 - 3.1e-06 26.6 0.1 5.3e-06 25.9 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain AA_permease PF00324.16 CCF42460.1 - 2.7e-134 448.0 33.9 3.1e-134 447.9 23.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF42460.1 - 7.8e-35 120.2 36.1 1.1e-34 119.7 25.0 1.1 1 0 0 1 1 1 1 Amino acid permease Abhydrolase_6 PF12697.2 CCF42462.1 - 1.1e-26 94.1 0.0 2.5e-26 92.9 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF42462.1 - 2e-19 70.0 0.0 1e-18 67.7 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF42462.1 - 7.7e-13 48.4 0.0 6.8e-10 38.8 0.0 2.4 2 1 0 2 2 2 2 Alpha/beta hydrolase family DUF915 PF06028.6 CCF42462.1 - 5.5e-07 28.9 0.0 1.4e-06 27.5 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Esterase PF00756.15 CCF42462.1 - 4.3e-05 23.0 0.0 7.7e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.8 CCF42462.1 - 0.0016 18.0 0.0 0.0083 15.7 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.2 CCF42462.1 - 0.0066 15.3 0.0 0.011 14.6 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.3 CCF42462.1 - 0.0086 15.9 0.0 0.07 12.9 0.0 2.3 2 0 0 2 2 2 1 Putative lysophospholipase Ser_hydrolase PF06821.8 CCF42462.1 - 0.01 15.4 0.0 0.019 14.5 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Thioesterase PF00975.15 CCF42462.1 - 0.011 15.9 0.0 0.064 13.4 0.0 2.2 1 1 0 1 1 1 0 Thioesterase domain Lipase_3 PF01764.20 CCF42462.1 - 0.016 14.7 0.0 0.037 13.6 0.0 1.6 2 0 0 2 2 2 0 Lipase (class 3) Abhydrolase_2 PF02230.11 CCF42462.1 - 0.043 13.2 0.0 9.4 5.6 0.0 3.0 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase DLH PF01738.13 CCF42462.1 - 0.058 12.6 0.0 0.61 9.3 0.0 2.4 2 1 0 2 2 2 0 Dienelactone hydrolase family Chlorophyllase PF07224.6 CCF42462.1 - 0.058 12.1 0.0 0.094 11.4 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase DUF2305 PF10230.4 CCF42462.1 - 0.15 11.4 0.0 0.28 10.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) MBOAT PF03062.14 CCF42463.1 - 2.9e-34 118.6 6.6 3.6e-34 118.3 4.5 1.0 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MTHFR PF02219.12 CCF42465.1 - 6.1e-102 340.5 0.0 8.5e-102 340.1 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Condensation PF00668.15 CCF42466.1 - 7.4e-08 31.5 0.1 1.3e-07 30.7 0.1 1.4 1 1 0 1 1 1 1 Condensation domain YchF-GTPase_C PF06071.8 CCF42467.1 - 2.1e-36 123.5 0.0 4.2e-36 122.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 CCF42467.1 - 1.2e-16 60.6 0.0 2.3e-16 59.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CCF42467.1 - 1e-07 31.3 0.0 2e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B DUF1254 PF06863.7 CCF42468.1 - 4.4e-29 100.9 2.0 6.5e-29 100.3 0.5 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1254) DUF1214 PF06742.6 CCF42468.1 - 2.4e-14 53.6 1.4 5.2e-14 52.5 0.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1214) TPP_enzyme_C PF02775.16 CCF42472.1 - 3.6e-26 91.5 0.2 1.3e-25 89.7 0.0 2.0 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 CCF42472.1 - 6.8e-20 71.2 0.0 1.1e-19 70.5 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain LIM PF00412.17 CCF42474.1 - 3.7e-21 74.9 18.5 4.4e-11 42.6 3.5 2.7 3 0 0 3 3 3 2 LIM domain c-SKI_SMAD_bind PF08782.5 CCF42474.1 - 2.3 8.4 5.7 1.8 8.7 0.4 2.4 2 0 0 2 2 2 0 c-SKI Smad4 binding domain Recep_L_domain PF01030.19 CCF42476.1 - 0.025 14.5 0.0 0.058 13.3 0.0 1.6 1 1 0 1 1 1 0 Receptor L domain G-patch PF01585.18 CCF42477.1 - 3e-12 46.1 1.5 6.7e-12 45.0 1.0 1.6 1 0 0 1 1 1 1 G-patch domain RRM_5 PF13893.1 CCF42477.1 - 3.6e-07 29.9 0.0 6.4e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CCF42477.1 - 6.7e-05 22.4 0.1 0.00012 21.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF42477.1 - 0.012 15.5 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) NAD_binding_6 PF08030.7 CCF42478.1 - 3.9e-14 52.8 0.0 5.5e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 CCF42478.1 - 8.4e-14 51.7 15.3 8.4e-14 51.7 10.6 2.3 2 1 1 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 CCF42478.1 - 7.3e-07 29.0 0.0 1.7e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain DUF793 PF05633.6 CCF42478.1 - 0.02 13.6 0.4 0.02 13.6 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF793) SR-25 PF10500.4 CCF42478.1 - 5.7 6.3 17.0 0.055 12.9 0.7 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein bZIP_1 PF00170.16 CCF42479.1 - 0.00039 20.3 4.2 0.00067 19.5 2.9 1.4 1 0 0 1 1 1 1 bZIP transcription factor Milton PF12448.3 CCF42479.1 - 0.054 13.6 3.8 0.086 13.0 2.7 1.3 1 0 0 1 1 1 0 Kinesin associated protein bZIP_Maf PF03131.12 CCF42479.1 - 0.057 13.7 4.1 0.12 12.7 2.8 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor Rad4 PF03835.10 CCF42479.1 - 0.067 12.6 3.1 0.085 12.2 2.2 1.2 1 0 0 1 1 1 0 Rad4 transglutaminase-like domain bZIP_2 PF07716.10 CCF42479.1 - 1.7 8.5 11.4 0.29 10.9 5.3 1.7 2 0 0 2 2 2 0 Basic region leucine zipper Creatinase_N PF01321.13 CCF42480.1 - 3.8e-11 43.5 0.0 4.2e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Xpo1 PF08389.7 CCF42481.1 - 0.00031 20.6 0.3 0.0053 16.6 0.3 2.7 2 1 0 2 2 2 1 Exportin 1-like protein tRNA-synt_1b PF00579.20 CCF42482.1 - 2.2e-72 243.6 0.0 2.8e-72 243.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA-synt_1f PF01921.13 CCF42482.1 - 0.13 10.9 0.0 0.22 10.1 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) Ribosomal_S10 PF00338.17 CCF42483.1 - 4.1e-22 77.8 0.0 6.3e-22 77.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Fcf2 PF08698.6 CCF42484.1 - 6.1e-25 87.1 0.0 2.2e-24 85.3 0.0 1.9 1 1 1 2 2 2 1 Fcf2 pre-rRNA processing DUF2740 PF10872.3 CCF42484.1 - 0.32 10.6 0.2 0.32 10.6 0.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2740) CBFD_NFYB_HMF PF00808.18 CCF42485.1 - 1.3e-19 70.0 0.6 2e-19 69.4 0.4 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 CCF42485.1 - 2.4e-11 43.5 0.1 3.6e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.5 CCF42485.1 - 0.021 14.6 0.0 0.032 14.0 0.0 1.3 1 0 0 1 1 1 0 CENP-S associating Centromere protein X TAFA PF12020.3 CCF42486.1 - 0.03 14.4 0.1 0.035 14.2 0.1 1.1 1 0 0 1 1 1 0 TAFA family Trypsin_2 PF13365.1 CCF42487.1 - 0.00074 19.4 0.0 0.0029 17.5 0.0 2.0 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S3 PF00944.14 CCF42487.1 - 0.01 15.2 0.1 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 Alphavirus core protein Peptidase_S32 PF05579.8 CCF42487.1 - 0.014 14.4 0.1 0.023 13.6 0.1 1.2 1 0 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 Pex16 PF08610.5 CCF42489.1 - 8.7e-105 350.4 0.0 1e-104 350.1 0.0 1.0 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) SRF-TF PF00319.13 CCF42490.1 - 4.7e-23 80.1 0.2 7.9e-23 79.4 0.1 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Metal_resist PF13801.1 CCF42491.1 - 0.054 13.4 0.1 0.058 13.3 0.0 1.1 1 0 0 1 1 1 0 Heavy-metal resistance Acetyltransf_7 PF13508.1 CCF42492.1 - 1.8e-07 31.2 0.0 3.8e-07 30.1 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CCF42492.1 - 7.5e-07 29.0 0.1 1.3e-06 28.3 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.1 CCF42492.1 - 2e-05 24.4 0.0 7.5e-05 22.5 0.0 2.0 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CCF42492.1 - 4.9e-05 23.4 0.0 0.00028 21.0 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF42492.1 - 0.00084 19.0 0.0 0.0015 18.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.1 CCF42492.1 - 0.0086 15.9 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase BcrAD_BadFG PF01869.15 CCF42495.1 - 0.023 14.0 0.1 0.56 9.4 0.0 2.1 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family MFS_1 PF07690.11 CCF42495.1 - 0.027 13.2 7.0 0.065 11.9 1.9 2.1 1 1 1 2 2 2 0 Major Facilitator Superfamily Pkinase PF00069.20 CCF42496.1 - 7.1e-59 199.0 0.0 9.3e-59 198.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF42496.1 - 1.7e-31 109.2 0.0 2.2e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF42496.1 - 1.1e-05 24.5 0.0 7.6e-05 21.8 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 CCF42496.1 - 0.0017 18.1 0.0 0.0034 17.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 CCF42496.1 - 0.0032 16.5 0.0 0.0049 15.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.6 CCF42496.1 - 0.15 10.8 0.2 0.27 9.9 0.0 1.4 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase Choline_kinase PF01633.15 CCF42496.1 - 0.19 11.3 0.0 0.32 10.5 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase YrbL-PhoP_reg PF10707.4 CCF42496.1 - 0.19 11.0 0.0 0.32 10.2 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Fungal_trans_2 PF11951.3 CCF42497.1 - 8.4e-07 27.9 0.2 1.1e-06 27.4 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF42497.1 - 0.00017 21.4 2.3 0.0003 20.6 1.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ATP-synt_C PF00137.16 CCF42498.1 - 2.4e-25 88.2 27.7 3.8e-16 58.7 6.5 2.1 2 0 0 2 2 2 2 ATP synthase subunit C TCR_zetazeta PF11628.3 CCF42498.1 - 0.13 11.7 0.9 20 4.7 0.2 2.6 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 zeta chain DUF4064 PF13273.1 CCF42498.1 - 3.7 7.7 13.3 0.99 9.5 2.4 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF4064) Chromo PF00385.19 CCF42499.1 - 6.4e-16 57.7 0.0 1.2e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AT_hook PF02178.14 CCF42499.1 - 0.68 9.8 21.9 0.15 11.8 2.2 4.0 3 0 0 3 3 3 0 AT hook motif PQ-loop PF04193.9 CCF42500.1 - 3e-21 74.7 3.3 4.4e-11 42.1 0.5 2.6 2 0 0 2 2 2 2 PQ loop repeat AMP-binding PF00501.23 CCF42502.1 - 2.3e-87 293.0 0.0 3.4e-87 292.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.20 CCF42502.1 - 4.5e-16 58.8 0.0 9.1e-16 57.8 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Condensation PF00668.15 CCF42502.1 - 8.9e-13 47.7 0.0 1.2e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Condensation domain AMP-binding_C PF13193.1 CCF42502.1 - 1.9e-05 25.5 0.0 5.4e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain NST1 PF13945.1 CCF42505.1 - 0.024 14.7 18.5 0.1 12.6 3.6 3.4 3 0 0 3 3 3 0 Salt tolerance down-regulator HSP70 PF00012.15 CCF42506.1 - 6.1e-266 883.1 14.6 6.9e-266 882.9 10.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 CCF42506.1 - 1.3e-15 56.7 2.8 4e-13 48.6 0.3 2.4 2 1 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 CCF42506.1 - 0.00016 21.3 0.2 0.00059 19.4 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 CCF42506.1 - 0.00067 19.4 5.3 14 5.5 3.7 4.4 1 1 0 1 1 1 1 Cell division protein FtsA AalphaY_MDB PF04611.7 CCF42506.1 - 0.085 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Mating type protein A alpha Y mating type dependent binding region Hydantoinase_A PF01968.13 CCF42506.1 - 0.23 10.4 5.4 1.4 7.9 0.7 3.4 2 1 0 2 2 2 0 Hydantoinase/oxoprolinase CCER1 PF15482.1 CCF42507.1 - 0.1 12.2 3.0 0.12 12.0 2.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 APG17 PF04108.7 CCF42508.1 - 3.4e-105 352.2 0.7 4e-105 351.9 0.5 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 GTPase_Cys_C PF12631.2 CCF42508.1 - 0.095 13.1 0.5 29 5.1 0.0 3.8 2 1 1 3 3 3 0 Catalytic cysteine-containing C-terminus of GTPase, MnmE DUF4358 PF14270.1 CCF42508.1 - 0.53 10.1 0.1 0.53 10.1 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4358) IncA PF04156.9 CCF42508.1 - 0.6 9.6 10.1 1.5 8.4 2.0 3.3 2 2 0 2 2 2 0 IncA protein DUF972 PF06156.8 CCF42508.1 - 5.4 7.4 6.1 15 5.9 0.1 3.7 2 2 2 4 4 4 0 Protein of unknown function (DUF972) TPR_MLP1_2 PF07926.7 CCF42508.1 - 7.5 6.2 8.5 9.4 5.9 0.8 2.9 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Ank PF00023.25 CCF42509.1 - 3.2e-18 64.5 1.1 1.8e-07 30.5 0.1 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.2 CCF42509.1 - 5.4e-17 61.9 0.7 6.9e-07 29.5 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF42509.1 - 7e-15 55.0 0.6 3.4e-05 24.2 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF42509.1 - 2.4e-14 53.0 0.7 4.1e-07 30.0 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF42509.1 - 4.5e-09 35.6 0.1 0.12 12.6 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat KilA-N PF04383.8 CCF42509.1 - 4.5e-08 32.6 0.2 3.5e-07 29.8 0.1 2.3 1 1 0 1 1 1 1 KilA-N domain DUF2802 PF10975.3 CCF42509.1 - 0.046 13.4 3.0 0.3 10.8 0.2 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) AAA_13 PF13166.1 CCF42509.1 - 0.11 10.8 7.5 0.037 12.4 2.9 1.7 1 1 0 1 1 1 0 AAA domain APG6 PF04111.7 CCF42509.1 - 0.66 8.9 9.8 0.099 11.6 3.5 1.9 2 0 0 2 2 2 0 Autophagy protein Apg6 Mnd1 PF03962.10 CCF42509.1 - 3.4 7.2 9.4 2.4 7.7 3.6 2.3 1 1 1 2 2 2 0 Mnd1 family AAA_23 PF13476.1 CCF42509.1 - 4 7.6 5.6 0.79 10.0 0.5 2.1 2 0 0 2 2 2 0 AAA domain Siah-Interact_N PF09032.6 CCF42509.1 - 6.1 6.9 10.6 0.36 10.9 1.6 3.1 2 1 0 2 2 2 0 Siah interacting protein, N terminal Arrestin_C PF02752.17 CCF42510.1 - 9.4e-17 61.3 1.0 2.7e-16 59.8 0.0 2.3 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 CCF42510.1 - 4.3e-08 33.0 0.0 0.0006 19.6 0.0 2.6 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain PLAC8 PF04749.12 CCF42511.1 - 3.4e-24 85.4 9.6 4.2e-24 85.1 6.6 1.1 1 0 0 1 1 1 1 PLAC8 family GMC_oxred_N PF00732.14 CCF42512.1 - 2.3e-63 214.1 0.2 3.6e-63 213.4 0.0 1.4 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF42512.1 - 5.1e-30 104.6 0.0 1.4e-29 103.2 0.0 1.8 2 0 0 2 2 2 1 GMC oxidoreductase DAO PF01266.19 CCF42512.1 - 4.6e-06 25.7 4.3 0.0013 17.7 1.0 2.6 2 1 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF42512.1 - 5.5e-05 23.1 0.0 0.00028 20.8 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF42512.1 - 0.00011 22.2 0.5 0.067 13.2 0.2 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF42512.1 - 0.00016 20.6 0.5 0.018 13.9 0.2 2.2 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.7 CCF42512.1 - 0.00031 19.7 0.1 0.00058 18.8 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_9 PF13454.1 CCF42512.1 - 0.0099 15.6 0.5 0.084 12.6 0.0 2.3 2 1 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 CCF42512.1 - 0.01 15.7 0.3 0.051 13.4 0.1 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF42512.1 - 0.011 14.7 0.1 0.022 13.8 0.0 1.4 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.9 CCF42512.1 - 0.06 11.8 0.1 0.24 9.8 0.0 1.8 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox PF00070.22 CCF42512.1 - 0.064 13.6 0.3 0.43 11.0 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Eno-Rase_NADH_b PF12242.3 CCF42512.1 - 0.23 11.2 1.8 4.8 7.0 0.0 3.0 3 0 0 3 3 3 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase BCNT PF07572.7 CCF42515.1 - 1.1e-26 92.5 1.4 1.8e-26 91.9 1.0 1.3 1 0 0 1 1 1 1 Bucentaur or craniofacial development DSBA PF01323.15 CCF42516.1 - 2.2e-15 56.7 0.0 9.5e-07 28.5 0.0 2.1 2 0 0 2 2 2 2 DSBA-like thioredoxin domain adh_short PF00106.20 CCF42517.1 - 1.3e-19 70.7 0.1 1.6e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF42517.1 - 8.4e-10 38.5 0.0 1e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF42517.1 - 1.9e-06 28.0 0.1 2.7e-06 27.4 0.1 1.1 1 0 0 1 1 1 1 NADH(P)-binding adh_short_C2 PF13561.1 CCF42517.1 - 0.00025 20.8 0.0 0.00026 20.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 CCF42517.1 - 0.0043 16.5 0.0 0.0058 16.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.5 CCF42517.1 - 0.0089 15.1 0.0 0.055 12.6 0.0 1.9 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) ThuA PF06283.6 CCF42517.1 - 0.023 14.4 0.0 0.067 12.8 0.0 1.7 1 1 1 2 2 2 0 Trehalose utilisation THF_DHG_CYH_C PF02882.14 CCF42517.1 - 0.028 13.4 0.0 0.064 12.3 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_2 PF03446.10 CCF42517.1 - 0.037 13.8 0.0 0.052 13.3 0.0 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Eno-Rase_NADH_b PF12242.3 CCF42517.1 - 0.07 12.9 0.2 0.16 11.8 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DHquinase_II PF01220.14 CCF42517.1 - 0.092 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Dehydroquinase class II Saccharop_dh PF03435.13 CCF42517.1 - 0.13 11.2 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase Glyco_hydro_47 PF01532.15 CCF42518.1 - 7.6e-116 387.4 0.0 2.5e-64 217.6 0.0 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 47 MscL PF01741.13 CCF42520.1 - 1.9e-16 60.3 0.7 4.1e-16 59.2 0.5 1.5 1 1 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL zf-BED PF02892.10 CCF42520.1 - 0.00064 19.4 1.7 0.00098 18.8 1.2 1.3 1 0 0 1 1 1 1 BED zinc finger C1_1 PF00130.17 CCF42520.1 - 0.068 12.9 1.7 0.11 12.1 1.2 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ArsA_ATPase PF02374.10 CCF42521.1 - 3.7e-94 315.2 0.0 4.5e-94 314.9 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.18 CCF42521.1 - 3.2e-17 62.5 0.3 1.4e-16 60.4 0.2 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 CCF42521.1 - 4.2e-09 36.5 0.0 3.4e-08 33.5 0.0 2.3 2 1 0 2 2 2 1 AAA domain Fer4_NifH PF00142.13 CCF42521.1 - 4.1e-06 26.1 0.0 6.3e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.17 CCF42521.1 - 8.8e-06 25.2 0.0 0.00048 19.6 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_10 PF12846.2 CCF42521.1 - 0.0016 17.9 0.0 0.0022 17.5 0.0 1.1 1 0 0 1 1 1 1 AAA-like domain AAA_19 PF13245.1 CCF42521.1 - 0.0021 17.7 0.0 0.0055 16.4 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_25 PF13481.1 CCF42521.1 - 0.0038 16.6 0.1 0.0099 15.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 CCF42521.1 - 0.004 16.6 0.0 0.0068 15.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein YhjQ PF06564.7 CCF42521.1 - 0.01 15.2 0.0 0.02 14.2 0.0 1.6 1 1 0 1 1 1 0 YhjQ protein MipZ PF09140.6 CCF42521.1 - 0.013 14.6 0.1 0.032 13.3 0.1 1.5 1 1 0 1 1 1 0 ATPase MipZ NB-ARC PF00931.17 CCF42521.1 - 0.05 12.4 0.0 0.086 11.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain T2SE PF00437.15 CCF42521.1 - 0.061 12.2 0.0 0.13 11.1 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.11 CCF42521.1 - 0.073 12.2 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_18 PF13238.1 CCF42521.1 - 0.091 13.0 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain KaiC PF06745.8 CCF42521.1 - 0.11 11.6 0.2 0.64 9.0 0.0 1.9 2 0 0 2 2 2 0 KaiC PDZ_1 PF12812.2 CCF42524.1 - 7.7e-56 185.9 0.0 9.9e-35 118.2 0.0 2.6 2 0 0 2 2 2 2 PDZ-like domain PDZ_2 PF13180.1 CCF42524.1 - 2.8e-14 52.7 2.1 9.1e-06 25.4 0.1 4.4 4 0 0 4 4 4 3 PDZ domain Trypsin_2 PF13365.1 CCF42524.1 - 8.5e-14 51.5 2.5 3.8e-12 46.2 0.0 3.2 3 1 0 3 3 3 1 Trypsin-like peptidase domain PDZ PF00595.19 CCF42524.1 - 9e-10 38.5 0.0 0.00013 22.0 0.0 3.8 4 0 0 4 4 4 2 PDZ domain (Also known as DHR or GLGF) Tricorn_PDZ PF14685.1 CCF42524.1 - 0.00016 21.3 0.4 0.0056 16.4 0.1 3.1 3 0 0 3 3 3 1 Tricorn protease PDZ domain Trypsin PF00089.21 CCF42524.1 - 0.00049 19.7 0.0 0.0018 17.8 0.0 2.0 2 0 0 2 2 2 1 Trypsin DUF2413 PF10310.4 CCF42525.1 - 1.5 7.5 16.9 2.1 7.0 11.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Pneumo_att_G PF05539.6 CCF42525.1 - 8.2 5.6 9.0 10 5.3 6.2 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G DnaJ PF00226.26 CCF42526.1 - 2.4e-22 78.4 1.6 4.6e-22 77.5 1.1 1.5 1 0 0 1 1 1 1 DnaJ domain zf-RING_2 PF13639.1 CCF42527.1 - 5.9e-09 35.6 8.2 1.1e-08 34.7 5.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 CCF42527.1 - 1.5e-07 31.4 2.4 3.3e-07 30.3 1.6 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger FANCL_C PF11793.3 CCF42527.1 - 5.9e-06 26.1 8.9 1.8e-05 24.6 6.2 1.8 1 1 0 1 1 1 1 FANCL C-terminal domain zf-Apc11 PF12861.2 CCF42527.1 - 0.00029 20.5 3.0 0.00073 19.3 2.1 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger C1_1 PF00130.17 CCF42527.1 - 0.0006 19.4 3.7 0.0006 19.4 2.5 1.7 1 1 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) RINGv PF12906.2 CCF42527.1 - 0.0017 18.3 8.8 0.0038 17.2 6.1 1.7 1 0 0 1 1 1 1 RING-variant domain zf-C3HC4 PF00097.20 CCF42527.1 - 0.0023 17.5 10.6 0.0044 16.6 7.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF42527.1 - 0.0044 16.6 5.6 0.0079 15.8 3.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CCF42527.1 - 0.016 15.2 9.3 0.032 14.2 6.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Baculo_RING PF05883.6 CCF42527.1 - 0.071 12.9 1.7 0.17 11.6 1.2 1.6 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain zf-RING-like PF08746.6 CCF42527.1 - 0.28 11.2 8.3 0.58 10.2 5.7 1.6 1 0 0 1 1 1 0 RING-like domain zf-RING_5 PF14634.1 CCF42527.1 - 1.7 8.4 9.4 3.1 7.6 6.5 1.5 1 0 0 1 1 1 0 zinc-RING finger domain PHD PF00628.24 CCF42527.1 - 3.3 7.4 7.8 6.7 6.4 5.4 1.6 1 0 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.1 CCF42527.1 - 6.5 6.4 7.7 55 3.4 5.4 2.2 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_1 PF14446.1 CCF42527.1 - 9.8 6.0 6.7 30 4.4 4.7 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 HypA PF01155.14 CCF42528.1 - 0.0056 16.3 0.8 0.008 15.8 0.6 1.2 1 0 0 1 1 1 1 Hydrogenase expression/synthesis hypA family FYDLN_acid PF09538.5 CCF42528.1 - 1.3 9.5 16.9 8.1 7.0 6.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) SAE2 PF08573.5 CCF42528.1 - 3.6 8.3 10.0 1.8 9.3 5.2 1.8 2 0 0 2 2 2 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Pkinase PF00069.20 CCF42529.1 - 8.7e-35 120.1 0.0 1.2e-34 119.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF42529.1 - 1.8e-07 30.5 0.0 3e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CCF42529.1 - 0.00034 20.4 0.1 0.086 12.5 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family HalX PF08663.5 CCF42529.1 - 4.6 7.2 6.5 7.6 6.6 0.3 2.7 3 0 0 3 3 3 0 HalX domain muHD PF10291.4 CCF42530.1 - 2.1e-71 240.1 0.0 3.1e-71 239.5 0.0 1.3 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.18 CCF42530.1 - 9.5e-10 38.5 0.7 7.7e-09 35.6 0.0 2.5 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DUF2458 PF10454.4 CCF42530.1 - 0.16 11.8 7.1 0.75 9.6 4.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2458) MAD PF05557.8 CCF42531.1 - 1.3e-50 172.3 64.4 3.1e-50 171.0 44.7 1.4 1 1 0 1 1 1 1 Mitotic checkpoint protein Mmp37 PF09139.6 CCF42532.1 - 1.8e-126 421.6 0.0 2.3e-126 421.3 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial matrix Mmp37 FA_desaturase PF00487.19 CCF42533.1 - 4.7e-14 52.4 11.5 5.5e-14 52.2 7.4 1.5 1 1 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 CCF42533.1 - 5.3e-10 38.9 0.0 1e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain HTH_psq PF05225.11 CCF42534.1 - 1.6e-13 49.9 0.0 3.6e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF42534.1 - 4.2e-10 39.2 0.1 9.7e-10 38.1 0.0 1.7 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.1 CCF42534.1 - 0.0026 17.3 0.1 0.034 13.7 0.0 2.6 2 1 0 2 2 2 1 Homeodomain-like domain DDE_1 PF03184.14 CCF42534.1 - 0.0067 15.5 0.0 0.012 14.7 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_28 PF13518.1 CCF42534.1 - 0.0083 16.1 0.0 0.087 12.8 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain DUF2537 PF10801.3 CCF42534.1 - 0.12 12.5 0.1 12 6.0 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2537) HTH_8 PF02954.14 CCF42534.1 - 0.15 11.6 0.1 0.55 9.8 0.0 2.0 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family Pectate_lyase PF03211.8 CCF42536.1 - 2.7e-48 164.2 5.0 3.3e-48 163.9 3.4 1.0 1 0 0 1 1 1 1 Pectate lyase PTRF_SDPR PF15237.1 CCF42537.1 - 0.036 13.4 0.0 0.06 12.7 0.0 1.3 1 0 0 1 1 1 0 PTRF/SDPR family Sugar_tr PF00083.19 CCF42538.1 - 6e-96 321.7 24.2 6.9e-96 321.5 16.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF42538.1 - 2.8e-31 108.5 34.6 2.1e-22 79.3 6.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF42538.1 - 0.058 13.1 6.8 2.4 8.0 0.2 3.7 3 1 1 4 4 4 0 MFS_1 like family CTP_transf_2 PF01467.21 CCF42541.1 - 3e-21 76.1 0.0 5.5e-21 75.2 0.0 1.5 1 0 0 1 1 1 1 Cytidylyltransferase OPT PF03169.10 CCF42542.1 - 1.1e-168 562.6 54.6 1.2e-168 562.4 37.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein zf-UDP PF14569.1 CCF42544.1 - 0.023 14.4 2.4 0.027 14.2 1.6 1.3 1 1 0 1 1 1 0 Zinc-binding RING-finger EGF_3 PF12947.2 CCF42544.1 - 8.9 6.3 7.6 9.9 6.2 0.6 2.8 2 1 0 2 2 2 0 EGF domain ADK PF00406.17 CCF42545.1 - 2e-23 82.9 0.0 3.4e-23 82.1 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase HD_3 PF13023.1 CCF42545.1 - 7.9e-18 64.7 0.0 1.3e-17 63.9 0.0 1.3 1 0 0 1 1 1 1 HD domain AAA_17 PF13207.1 CCF42545.1 - 2e-08 35.0 0.1 3.1e-07 31.2 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 CCF42545.1 - 0.00015 22.0 0.0 0.00036 20.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF42545.1 - 0.00021 21.3 0.1 0.00068 19.6 0.0 1.8 1 1 1 2 2 2 1 AAA ATPase domain AAA PF00004.24 CCF42545.1 - 0.0013 18.9 0.0 0.004 17.3 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) HD PF01966.17 CCF42545.1 - 0.002 18.1 0.5 0.0054 16.7 0.2 1.9 1 1 0 1 1 1 1 HD domain AAA_19 PF13245.1 CCF42545.1 - 0.0037 16.9 0.0 0.011 15.4 0.0 1.8 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 CCF42545.1 - 0.0065 16.6 0.0 0.013 15.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 CCF42545.1 - 0.012 14.7 0.0 0.33 10.0 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin AAA_33 PF13671.1 CCF42545.1 - 0.023 14.5 0.0 0.13 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.7 CCF42545.1 - 0.027 13.5 0.0 0.038 13.0 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus Thymidylate_kin PF02223.12 CCF42545.1 - 0.036 13.4 0.0 0.15 11.4 0.0 1.8 2 0 0 2 2 2 0 Thymidylate kinase NTPase_1 PF03266.10 CCF42545.1 - 0.057 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_29 PF13555.1 CCF42545.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain APH PF01636.18 CCF42546.1 - 5.3e-09 36.1 1.3 1.4e-08 34.7 0.7 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family Fungal_trans_2 PF11951.3 CCF42547.1 - 0.00027 19.6 0.3 0.00041 19.0 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF42547.1 - 0.086 12.7 13.8 0.094 12.6 3.1 2.6 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_transf_28 PF03033.15 CCF42548.1 - 2e-24 85.9 0.2 3.6e-24 85.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain PYRIN PF02758.11 CCF42549.1 - 0.13 12.0 0.0 0.17 11.5 0.0 1.4 1 1 0 1 1 1 0 PAAD/DAPIN/Pyrin domain Alg14 PF08660.6 CCF42550.1 - 1.3e-28 100.0 0.0 1.6e-28 99.8 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like MRP-S25 PF13741.1 CCF42551.1 - 4.5e-72 242.2 5.3 1.2e-69 234.2 3.7 2.0 1 1 0 1 1 1 1 Mitochondrial ribosomal protein S25 Yos1 PF08571.5 CCF42553.1 - 0.1 12.7 0.0 0.1 12.7 0.0 1.1 1 0 0 1 1 1 0 Yos1-like ADK PF00406.17 CCF42554.1 - 1.3e-22 80.2 0.0 1.9e-22 79.7 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.1 CCF42554.1 - 0.00026 21.7 0.0 0.00038 21.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CCF42554.1 - 0.03 14.2 0.0 0.046 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Glyco_hydro_72 PF03198.9 CCF42556.1 - 2.6e-122 407.7 4.5 3.3e-122 407.3 3.1 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.13 CCF42556.1 - 3.9e-05 22.9 0.9 0.00071 18.8 0.6 2.3 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) RNase_H2-Ydr279 PF09468.5 CCF42557.1 - 1.6e-82 277.1 1.9 2.3e-82 276.5 1.3 1.2 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) DASH_Duo1 PF08651.5 CCF42558.1 - 1.4e-29 101.4 0.3 2e-29 100.9 0.2 1.2 1 0 0 1 1 1 1 DASH complex subunit Duo1 DUF3367 PF11847.3 CCF42558.1 - 0.12 10.3 1.4 0.12 10.2 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3367) DUF1682 PF07946.9 CCF42558.1 - 0.12 11.2 3.1 0.15 10.8 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) SWIRM PF04433.12 CCF42559.1 - 5.6e-13 48.8 0.0 1e-12 47.9 0.0 1.5 1 0 0 1 1 1 1 SWIRM domain ADH_zinc_N_2 PF13602.1 CCF42560.1 - 8e-25 88.1 0.5 1.6e-24 87.1 0.3 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 CCF42560.1 - 1.3e-14 53.8 0.4 5.9e-14 51.7 0.2 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF42560.1 - 1.3e-07 31.3 0.6 2.5e-06 27.2 0.0 2.7 2 2 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain CytB6-F_Fe-S PF08802.5 CCF42560.1 - 2.4 8.2 4.7 2.6 8.0 1.0 2.6 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit Pkinase PF00069.20 CCF42562.1 - 1.4e-15 57.1 0.0 1.5e-12 47.2 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CCF42562.1 - 7.8e-05 21.8 0.0 0.00015 20.9 0.0 1.5 1 1 1 2 2 2 1 Protein tyrosine kinase Kdo PF06293.9 CCF42562.1 - 0.003 16.6 0.0 0.0042 16.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PBP_GOBP PF01395.17 CCF42562.1 - 0.0084 15.7 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 PBP/GOBP family RIO1 PF01163.17 CCF42562.1 - 0.12 11.7 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 RIO1 family DUF2829 PF11195.3 CCF42562.1 - 0.19 12.1 0.4 0.56 10.7 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2829) DDE_1 PF03184.14 CCF42563.1 - 1.3e-46 158.5 0.0 1.7e-46 158.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.11 CCF42563.1 - 6.9e-11 41.5 0.2 1.5e-10 40.4 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.1 CCF42563.1 - 1.2e-07 31.6 0.0 1.8e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 CCF42563.1 - 1.5e-05 24.6 0.0 4.2e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_AsnC-type PF13404.1 CCF42563.1 - 0.0063 16.0 0.0 0.014 14.9 0.0 1.6 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_23 PF13384.1 CCF42563.1 - 0.011 15.3 0.1 0.03 13.9 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_28 PF13518.1 CCF42563.1 - 0.019 14.9 0.1 0.094 12.7 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_24 PF13412.1 CCF42563.1 - 0.021 14.2 0.1 0.045 13.1 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding IF-2B PF01008.12 CCF42564.1 - 2.8e-19 69.1 0.0 4.6e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 Initiation factor 2 subunit family NUDIX PF00293.23 CCF42564.1 - 2.8e-12 46.4 0.2 4.8e-12 45.6 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain DUF3437 PF11919.3 CCF42564.1 - 0.025 14.2 0.0 0.34 10.6 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) DUF2716 PF10898.3 CCF42564.1 - 0.079 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2716) MFS_1 PF07690.11 CCF42565.1 - 0.14 10.8 6.7 0.25 10.0 4.7 1.5 1 1 0 1 1 1 0 Major Facilitator Superfamily Ribosomal_L30_N PF08079.7 CCF42566.1 - 3.1e-23 81.5 18.0 5.2e-23 80.8 12.4 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.15 CCF42566.1 - 7.8e-18 63.8 1.7 7.8e-18 63.8 1.2 1.7 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e ERCC4 PF02732.10 CCF42566.1 - 0.044 13.5 0.5 0.073 12.8 0.4 1.3 1 0 0 1 1 1 0 ERCC4 domain Ribosomal_S11 PF00411.14 CCF42567.1 - 9.7e-41 138.3 0.5 1.2e-40 138.1 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 DUF2252 PF10009.4 CCF42567.1 - 0.071 12.0 0.0 0.089 11.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) SNF2_N PF00176.18 CCF42568.1 - 8.5e-71 238.1 0.0 1.3e-70 237.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CCF42568.1 - 2.9e-13 49.4 0.0 1.9e-12 46.8 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 CCF42568.1 - 0.0002 20.8 0.0 0.00077 18.9 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase APG6 PF04111.7 CCF42568.1 - 2.6 7.0 9.2 4.8 6.1 6.4 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 ApbA_C PF08546.6 CCF42569.1 - 6e-13 48.8 0.0 6e-13 48.8 0.0 1.0 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal MFS_1 PF07690.11 CCF42570.1 - 2.5e-39 134.9 21.7 2.5e-39 134.9 15.1 2.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF42570.1 - 3.9e-13 48.7 14.8 3.9e-13 48.7 10.3 2.9 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 CCF42570.1 - 0.0049 15.1 3.8 0.0085 14.3 2.6 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) AMP-binding PF00501.23 CCF42571.1 - 2.9e-59 200.5 0.0 3.9e-59 200.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme HLH PF00010.21 CCF42572.1 - 1.2e-12 47.3 0.2 2.2e-12 46.4 0.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF607 PF04678.8 CCF42573.1 - 5.6e-40 137.1 0.3 1.5e-39 135.7 0.2 1.8 1 1 0 1 1 1 1 Protein of unknown function, DUF607 p450 PF00067.17 CCF42574.1 - 8.3e-29 100.4 0.0 1e-28 100.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.20 CCF42575.1 - 1.2e-17 64.3 0.3 5.8e-17 62.1 0.0 2.0 1 1 1 2 2 2 1 short chain dehydrogenase KR PF08659.5 CCF42575.1 - 5.8e-09 35.8 0.0 1.2e-08 34.8 0.0 1.6 2 0 0 2 2 2 1 KR domain Epimerase PF01370.16 CCF42575.1 - 0.00023 20.7 0.0 0.00041 19.8 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 CCF42575.1 - 0.00074 18.5 0.0 0.0019 17.1 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.15 CCF42575.1 - 0.12 12.5 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF1593 PF07632.6 CCF42576.1 - 3.1e-88 295.4 0.0 4.4e-88 294.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) REJ PF02010.10 CCF42576.1 - 0.0061 14.9 0.0 0.0082 14.5 0.0 1.1 1 0 0 1 1 1 1 REJ domain Pet127 PF08634.5 CCF42577.1 - 6.9e-121 402.5 2.0 1.1e-120 401.8 1.4 1.3 1 0 0 1 1 1 1 Mitochondrial protein Pet127 DUF824 PF05688.6 CCF42577.1 - 0.034 13.7 0.0 0.098 12.3 0.0 1.7 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF824) HATPase_c PF02518.21 CCF42582.1 - 3.2e-28 97.6 0.1 7.6e-28 96.4 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 CCF42582.1 - 2.1e-20 72.4 0.2 7.9e-20 70.6 0.1 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.19 CCF42582.1 - 2.6e-15 56.3 0.2 1.5e-14 53.9 0.2 2.3 1 1 0 1 1 1 1 Response regulator receiver domain AAA_16 PF13191.1 CCF42582.1 - 6.5e-13 49.0 0.0 2.6e-12 47.1 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain GAF_2 PF13185.1 CCF42582.1 - 1.4e-10 41.8 0.0 4.5e-10 40.1 0.0 2.0 1 0 0 1 1 1 1 GAF domain Pkinase PF00069.20 CCF42582.1 - 4.6e-09 35.8 0.0 1.1e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain GAF_3 PF13492.1 CCF42582.1 - 3.8e-08 33.5 0.0 8.4e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 GAF domain TPR_8 PF13181.1 CCF42582.1 - 6.4e-05 22.4 0.7 0.23 11.3 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat HATPase_c_3 PF13589.1 CCF42582.1 - 0.00043 19.9 0.0 0.001 18.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TPR_12 PF13424.1 CCF42582.1 - 0.0058 16.5 14.7 0.025 14.4 2.5 3.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 CCF42582.1 - 0.0074 15.9 13.3 0.11 12.1 0.9 3.9 4 0 0 4 4 4 2 TPR repeat AAA_22 PF13401.1 CCF42582.1 - 0.011 15.9 0.0 0.76 9.9 0.0 3.0 2 0 0 2 2 2 0 AAA domain Pkinase_Tyr PF07714.12 CCF42582.1 - 0.031 13.3 0.0 0.058 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase ArgK PF03308.11 CCF42582.1 - 0.13 10.9 0.0 0.28 9.9 0.0 1.5 1 0 0 1 1 1 0 ArgK protein TPR_2 PF07719.12 CCF42582.1 - 0.34 10.9 10.9 1 9.4 0.1 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 CCF42582.1 - 7.2 6.6 7.7 2.4 8.1 0.3 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat MTS PF05175.9 CCF42583.1 - 0.0024 17.2 0.0 0.0026 17.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.1 CCF42583.1 - 0.0044 16.7 0.0 0.005 16.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF42583.1 - 0.012 16.2 0.2 0.015 15.8 0.1 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 CCF42583.1 - 0.034 13.7 0.0 0.039 13.5 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain CoA_binding_2 PF13380.1 CCF42584.1 - 1.2e-27 96.3 0.0 1.5e-27 96.0 0.0 1.1 1 0 0 1 1 1 1 CoA binding domain CoA_binding PF02629.14 CCF42584.1 - 0.12 12.8 0.0 0.19 12.2 0.0 1.2 1 0 0 1 1 1 0 CoA binding domain Mitofilin PF09731.4 CCF42585.1 - 4.8 5.7 29.2 6.5 5.2 20.3 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DASH_Dad2 PF08654.5 CCF42586.1 - 0.02 14.8 0.4 0.03 14.2 0.3 1.6 1 1 0 1 1 1 0 DASH complex subunit Dad2 Nbl1_Borealin_N PF10444.4 CCF42586.1 - 0.13 11.6 0.5 0.26 10.6 0.3 1.6 1 1 0 1 1 1 0 Nbl1 / Borealin N terminal PCI PF01399.22 CCF42587.1 - 2.2e-10 40.7 0.0 8.8e-10 38.8 0.0 1.9 1 0 0 1 1 1 1 PCI domain RPN7 PF10602.4 CCF42587.1 - 0.018 14.4 0.1 0.046 13.0 0.1 1.6 1 1 0 1 1 1 0 26S proteasome subunit RPN7 PPE PF00823.14 CCF42587.1 - 0.089 12.6 4.3 0.71 9.6 0.1 3.2 3 0 0 3 3 3 0 PPE family TPR_12 PF13424.1 CCF42587.1 - 0.095 12.6 0.7 0.85 9.5 0.2 2.4 1 1 2 3 3 3 0 Tetratricopeptide repeat peroxidase PF00141.18 CCF42588.1 - 3.6e-25 88.7 0.1 5.2e-25 88.2 0.1 1.2 1 0 0 1 1 1 1 Peroxidase DUF3415 PF11895.3 CCF42588.1 - 0.00028 20.6 0.0 0.00068 19.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3415) DUF3446 PF11928.3 CCF42588.1 - 0.16 12.1 5.9 0.49 10.6 1.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) PNP_UDP_1 PF01048.15 CCF42589.1 - 3e-11 42.7 0.0 8.4e-11 41.2 0.0 1.7 1 1 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.7 CCF42589.1 - 3.4e-09 36.5 0.1 7.9e-09 35.3 0.1 1.7 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 CCF42589.1 - 1.8e-06 28.0 0.0 4.1e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CCF42589.1 - 2e-05 24.7 0.0 4.4e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.17 CCF42589.1 - 5.9e-05 22.0 0.0 0.00011 21.1 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA PF00004.24 CCF42589.1 - 0.00056 20.1 0.1 0.0044 17.2 0.1 2.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CCF42589.1 - 0.0048 17.6 0.0 0.018 15.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 CCF42589.1 - 0.0055 16.4 0.0 0.0098 15.6 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase AAA_18 PF13238.1 CCF42589.1 - 0.014 15.7 0.0 0.057 13.7 0.0 2.1 1 1 0 1 1 1 0 AAA domain APS_kinase PF01583.15 CCF42589.1 - 0.024 14.2 0.0 0.048 13.3 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase Zeta_toxin PF06414.7 CCF42589.1 - 0.041 12.9 0.0 1.1 8.3 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin AAA_33 PF13671.1 CCF42589.1 - 0.054 13.3 0.0 0.23 11.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 CCF42589.1 - 0.055 13.3 0.1 1.1 9.1 0.0 2.8 2 1 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.12 CCF42589.1 - 0.081 11.7 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 RNA_helicase PF00910.17 CCF42589.1 - 0.15 12.2 0.0 0.37 10.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase PfkB PF00294.19 CCF42590.1 - 5e-67 226.1 0.2 5.8e-67 225.9 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 CCF42590.1 - 0.0026 17.0 0.0 0.0054 15.9 0.0 1.5 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Fer2_3 PF13085.1 CCF42590.1 - 0.17 11.6 0.1 3.4 7.5 0.1 2.3 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Sec23_trunk PF04811.10 CCF42594.1 - 4.7e-51 173.4 0.0 1.2e-50 172.1 0.0 1.7 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 CCF42594.1 - 2.2e-25 88.0 0.1 3.7e-25 87.3 0.1 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 CCF42594.1 - 4.5e-18 65.5 0.0 8.5e-18 64.6 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 CCF42594.1 - 2.2e-16 59.1 5.5 4.5e-16 58.1 3.8 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 CCF42594.1 - 1.7e-05 24.4 0.0 4.1e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat CPSF100_C PF13299.1 CCF42595.1 - 6.4e-45 153.2 1.2 6.4e-45 153.2 0.8 2.2 3 0 0 3 3 3 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.3 CCF42595.1 - 3.1e-26 91.7 0.0 1.1e-25 89.9 0.0 2.0 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.7 CCF42595.1 - 2.7e-06 27.1 0.0 6.8e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase AA_permease PF00324.16 CCF42598.1 - 2.6e-139 464.6 33.7 3.2e-139 464.3 23.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF42598.1 - 1e-39 136.2 31.3 1.4e-39 135.8 21.7 1.1 1 0 0 1 1 1 1 Amino acid permease UPF0261 PF06792.6 CCF42598.1 - 0.23 9.9 0.1 0.35 9.2 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0261) Hormone_4 PF00220.12 CCF42599.1 - 4.1 7.2 7.4 3.1 7.6 0.1 3.2 3 0 0 3 3 3 0 Neurohypophysial hormones, N-terminal Domain MFS_1 PF07690.11 CCF42600.1 - 2.9e-24 85.4 20.6 3.4e-24 85.2 14.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF42600.1 - 2.6e-09 36.2 12.0 3.3e-09 35.8 8.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 CCF42600.1 - 1.5e-05 23.3 6.8 1.9e-05 23.1 4.7 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF791 PF05631.9 CCF42600.1 - 0.013 14.2 0.4 0.016 13.9 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF791) PP-binding PF00550.20 CCF42601.1 - 2.9e-12 46.6 0.1 6.1e-12 45.6 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site PS-DH PF14765.1 CCF42601.1 - 3.1e-10 39.7 3.8 1.8e-05 24.0 0.1 2.8 1 1 2 3 3 3 2 Polyketide synthase dehydratase Choline_transpo PF04515.7 CCF42602.1 - 2.6e-106 355.1 19.6 2.6e-106 355.1 13.6 2.2 1 1 1 2 2 2 1 Plasma-membrane choline transporter AMP-binding PF00501.23 CCF42605.1 - 1.3e-48 165.4 0.0 1.6e-48 165.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF42605.1 - 1.7e-06 28.8 0.1 5e-06 27.3 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain CoA_transf_3 PF02515.12 CCF42606.1 - 2.3e-25 88.9 0.2 1.9e-24 85.9 0.0 2.1 2 0 0 2 2 2 1 CoA-transferase family III Na_H_Exchanger PF00999.16 CCF42607.1 - 8.2e-32 110.1 35.8 1.6e-25 89.4 16.3 3.1 3 0 0 3 3 3 3 Sodium/hydrogen exchanger family Rep-A_N PF04057.7 CCF42608.1 - 0.017 14.9 0.0 0.044 13.5 0.0 1.6 2 0 0 2 2 2 0 Replication factor-A protein 1, N-terminal domain Avian_gp85 PF03708.9 CCF42610.1 - 0.072 12.3 0.1 0.074 12.2 0.0 1.0 1 0 0 1 1 1 0 Avian retrovirus envelope protein, gp85 Rubella_E1 PF05748.6 CCF42610.1 - 0.094 11.3 0.0 0.1 11.2 0.0 1.0 1 0 0 1 1 1 0 Rubella membrane glycoprotein E1 DUF2613 PF11021.3 CCF42610.1 - 0.1 12.3 0.1 0.15 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) MFS_1 PF07690.11 CCF42611.1 - 2.1e-49 168.1 39.3 2.6e-49 167.8 27.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF42611.1 - 5.8e-14 51.5 22.4 1.3e-13 50.3 15.5 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_3 PF05977.8 CCF42611.1 - 0.16 10.0 9.1 0.14 10.2 5.6 1.4 1 1 0 1 1 1 0 Transmembrane secretion effector DDE_1 PF03184.14 CCF42612.1 - 1.6e-25 89.5 0.0 2.5e-25 88.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 CCF42612.1 - 5.3e-12 45.3 0.1 1.1e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF42612.1 - 7.2e-12 44.6 0.2 1.3e-11 43.8 0.2 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_28 PF13518.1 CCF42612.1 - 0.00045 20.1 0.9 0.0012 18.8 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 CCF42612.1 - 0.0013 18.2 0.1 0.004 16.7 0.1 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.10 CCF42612.1 - 0.006 16.4 0.6 0.011 15.5 0.4 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_29 PF13551.1 CCF42612.1 - 0.013 15.6 0.5 0.035 14.2 0.4 1.8 1 1 0 1 1 1 0 Winged helix-turn helix HTH_8 PF02954.14 CCF42612.1 - 0.014 14.8 0.1 0.042 13.3 0.1 1.8 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_Tnp_IS630 PF01710.11 CCF42612.1 - 0.015 14.9 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 Transposase HTH_Tnp_1 PF01527.15 CCF42612.1 - 0.075 12.9 0.3 0.28 11.1 0.0 2.0 3 0 0 3 3 3 0 Transposase Methyltransf_2 PF00891.13 CCF42613.1 - 5.1e-39 133.9 0.0 7e-39 133.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_23 PF13489.1 CCF42613.1 - 0.00031 20.5 0.0 0.0024 17.6 0.0 2.3 1 1 1 2 2 2 1 Methyltransferase domain DUF3940 PF13076.1 CCF42613.1 - 0.029 13.9 0.1 0.095 12.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3940) Glucokinase PF02685.11 CCF42613.1 - 0.11 11.2 0.0 0.18 10.5 0.0 1.3 1 0 0 1 1 1 0 Glucokinase Abhydrolase_6 PF12697.2 CCF42615.1 - 1.2e-05 25.3 0.0 1.5e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 CCF42615.1 - 7.2e-05 22.4 0.0 0.00011 21.9 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.2 CCF42615.1 - 0.00029 20.6 0.0 0.00044 20.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.9 CCF42615.1 - 0.00049 19.4 0.0 0.0008 18.7 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Cutinase PF01083.17 CCF42615.1 - 0.015 15.0 0.0 0.022 14.5 0.0 1.2 1 0 0 1 1 1 0 Cutinase Abhydrolase_1 PF00561.15 CCF42615.1 - 0.016 14.7 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Frizzled PF01534.12 CCF42615.1 - 0.087 11.5 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Frizzled/Smoothened family membrane region NAD_binding_8 PF13450.1 CCF42616.1 - 2.7e-09 36.9 0.3 7.1e-09 35.5 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 CCF42616.1 - 4.5e-07 29.3 0.1 1.2e-05 24.6 0.0 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.2 CCF42616.1 - 6.4e-07 28.7 2.5 9.6e-07 28.2 0.9 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CCF42616.1 - 3.2e-06 26.2 3.0 4.8e-06 25.6 2.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.1 CCF42616.1 - 8.4e-06 25.9 0.0 2.3e-05 24.5 0.0 1.8 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF42616.1 - 2.3e-05 23.0 2.2 3.7e-05 22.3 1.5 1.2 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.12 CCF42616.1 - 2.8e-05 23.3 0.6 4.9e-05 22.5 0.4 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.9 CCF42616.1 - 5.1e-05 23.2 0.5 0.00012 22.0 0.3 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF42616.1 - 6.4e-05 22.0 1.0 9.9e-05 21.3 0.3 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 CCF42616.1 - 0.00024 20.3 0.1 0.00032 19.8 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.17 CCF42616.1 - 0.0022 16.9 1.2 0.0033 16.3 0.8 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.22 CCF42616.1 - 0.0088 16.4 0.4 0.024 15.0 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 CCF42616.1 - 0.027 14.7 0.0 0.047 13.9 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding RRM_1 PF00076.17 CCF42616.1 - 0.056 13.0 0.0 0.24 11.0 0.0 2.0 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AlaDh_PNT_C PF01262.16 CCF42616.1 - 0.059 12.9 0.6 0.12 11.9 0.4 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.7 CCF42616.1 - 0.092 11.6 0.2 0.15 10.9 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Trp_halogenase PF04820.9 CCF42616.1 - 0.2 10.2 1.0 0.29 9.7 0.7 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Septin PF00735.13 CCF42617.1 - 2.1e-105 351.8 0.0 4.8e-105 350.6 0.0 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 CCF42617.1 - 0.00029 20.7 0.0 0.00054 19.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 CCF42617.1 - 0.0058 16.4 5.6 0.83 9.4 0.0 3.0 2 1 1 3 3 3 2 Dynamin family DUF258 PF03193.11 CCF42617.1 - 0.0098 15.0 0.3 0.041 13.0 0.2 1.9 1 1 0 1 1 1 1 Protein of unknown function, DUF258 IIGP PF05049.8 CCF42617.1 - 0.017 13.9 0.0 0.029 13.2 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Miro PF08477.8 CCF42617.1 - 0.022 15.2 0.0 0.065 13.7 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein AAA_22 PF13401.1 CCF42617.1 - 0.067 13.3 0.0 0.25 11.4 0.0 2.0 1 1 0 1 1 1 0 AAA domain GTP_EFTU PF00009.22 CCF42617.1 - 0.073 12.4 0.0 0.2 11.0 0.0 1.7 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain GLE1 PF07817.8 CCF42617.1 - 0.15 10.9 0.5 0.24 10.2 0.3 1.2 1 0 0 1 1 1 0 GLE1-like protein FMN_bind PF04205.9 CCF42617.1 - 0.19 11.8 0.5 0.72 10.0 0.0 2.1 2 0 0 2 2 2 0 FMN-binding domain DUF3653 PF12375.3 CCF42617.1 - 0.27 11.4 2.7 15 5.8 1.3 2.9 2 1 0 2 2 2 0 Phage protein AAA_17 PF13207.1 CCF42617.1 - 0.29 11.9 5.3 0.44 11.3 0.3 2.9 1 1 1 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 CCF42617.1 - 3 7.2 5.8 0.31 10.4 0.2 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family Zn_clus PF00172.13 CCF42620.1 - 1.6e-09 37.5 10.9 2.4e-09 36.9 7.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF42620.1 - 5.9e-05 21.8 0.0 0.0003 19.5 0.0 1.9 1 1 0 2 2 2 1 Fungal specific transcription factor domain MFS_1 PF07690.11 CCF42621.1 - 1e-29 103.3 37.0 1e-29 103.3 25.6 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Peptidase_M19 PF01244.16 CCF42622.1 - 1.6e-101 339.4 0.0 1.8e-101 339.2 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) EF-hand_1 PF00036.27 CCF42625.1 - 5.7e-26 87.8 4.0 5.6e-06 25.2 0.0 5.4 5 1 0 5 5 5 5 EF hand EF-hand_7 PF13499.1 CCF42625.1 - 2.8e-23 81.8 1.4 1.6e-08 34.5 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 CCF42625.1 - 1.7e-20 70.9 4.3 0.00072 19.2 0.4 5.3 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.1 CCF42625.1 - 3.4e-20 71.3 6.2 2.7e-09 36.4 0.0 4.7 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.1 CCF42625.1 - 1.4e-17 62.1 5.5 0.00056 19.1 0.0 4.6 4 0 0 4 4 4 4 EF hand Sugar_tr PF00083.19 CCF42626.1 - 2.3e-60 204.4 33.8 3e-60 204.1 23.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF42626.1 - 3.9e-22 78.4 33.1 6.7e-22 77.6 22.9 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Vps8 PF12816.2 CCF42627.1 - 1.6e-74 249.3 0.0 2.8e-74 248.6 0.0 1.4 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.15 CCF42627.1 - 1.1e-05 25.0 0.0 0.088 12.4 0.0 3.2 4 0 0 4 4 4 2 Region in Clathrin and VPS zf-RING_2 PF13639.1 CCF42627.1 - 0.00045 19.9 0.2 0.0012 18.6 0.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 CCF42627.1 - 0.0097 15.6 0.0 0.0097 15.6 0.0 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CCF42627.1 - 0.049 13.6 1.2 0.089 12.8 0.1 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Glyco_hydro_46 PF01374.13 CCF42627.1 - 0.13 11.7 0.1 0.25 10.8 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 46 HEAT_EZ PF13513.1 CCF42628.1 - 2.7e-13 49.9 10.8 9.7e-07 29.1 0.0 8.4 7 3 2 9 9 9 2 HEAT-like repeat HEAT PF02985.17 CCF42628.1 - 4e-12 45.1 16.3 0.015 15.2 0.0 10.4 12 0 0 12 12 12 3 HEAT repeat HEAT_2 PF13646.1 CCF42628.1 - 3.9e-11 43.0 14.8 1.9e-05 24.8 0.0 7.6 3 2 4 7 7 7 3 HEAT repeats IBN_N PF03810.14 CCF42628.1 - 7.7e-08 32.1 0.4 0.00012 21.9 0.0 4.1 3 0 0 3 3 3 1 Importin-beta N-terminal domain CLASP_N PF12348.3 CCF42628.1 - 5.9e-07 29.0 1.3 1.5 8.0 0.0 5.0 3 1 2 5 5 5 3 CLASP N terminal MMS19_C PF12460.3 CCF42628.1 - 2.3e-05 23.3 1.3 0.00015 20.6 0.2 2.6 2 1 0 3 3 3 1 RNAPII transcription regulator C-terminal RIX1 PF08167.7 CCF42628.1 - 0.00015 21.4 0.2 2.2 7.9 0.0 5.0 3 2 2 5 5 5 1 rRNA processing/ribosome biogenesis Arm PF00514.18 CCF42628.1 - 0.023 14.5 3.4 27 4.7 0.0 5.5 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat HEAT_PBS PF03130.11 CCF42628.1 - 0.069 13.6 0.3 42 5.0 0.0 4.9 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Sugar_tr PF00083.19 CCF42629.1 - 1.6e-95 320.3 22.5 1.9e-95 320.1 15.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF42629.1 - 8.1e-23 80.6 35.6 4.6e-18 65.0 13.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF42629.1 - 0.00036 18.8 4.2 0.00063 18.0 0.4 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) PAM2 PF07145.10 CCF42630.1 - 0.0051 16.2 0.1 0.033 13.7 0.0 2.4 2 0 0 2 2 2 1 Ataxin-2 C-terminal region MFS_1 PF07690.11 CCF42631.1 - 1.2e-12 47.2 41.2 1.2e-12 47.2 28.6 2.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Fungal_trans PF04082.13 CCF42633.1 - 4.2e-15 55.3 0.0 6.5e-15 54.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF42633.1 - 6.6e-06 25.9 13.1 1e-05 25.3 9.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_7 PF00840.15 CCF42634.1 - 8.6e-204 676.8 17.8 1.1e-203 676.5 12.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 CBM_1 PF00734.13 CCF42634.1 - 1.9e-06 27.4 1.1 1.9e-06 27.4 0.8 3.8 4 0 0 4 4 4 1 Fungal cellulose binding domain ADH_N PF08240.7 CCF42636.1 - 1.4e-21 76.2 1.2 1.8e-21 75.9 0.2 1.6 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF42636.1 - 1.1e-13 50.7 4.1 2e-13 50.0 2.8 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Antimicrobial_6 PF08036.6 CCF42636.1 - 0.034 13.8 0.0 0.094 12.4 0.0 1.7 1 0 0 1 1 1 0 Diapausin family of antimicrobial peptide FOLN PF09289.5 CCF42637.1 - 0.032 14.0 1.2 0.15 11.9 0.9 2.2 1 1 0 1 1 1 0 Follistatin/Osteonectin-like EGF domain NAD_binding_5 PF07994.7 CCF42639.1 - 1.7e-109 365.8 0.0 2.2e-109 365.5 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.12 CCF42639.1 - 9.4e-46 154.2 0.5 1.5e-45 153.5 0.3 1.3 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase PP-binding PF00550.20 CCF42641.1 - 0.0001 22.4 0.3 0.00013 22.1 0.2 1.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site GTPase_Cys_C PF12631.2 CCF42643.1 - 3.8e-21 75.2 0.7 2e-20 72.9 0.1 2.5 2 0 0 2 2 2 1 Catalytic cysteine-containing C-terminus of GTPase, MnmE TrmE_N PF10396.4 CCF42643.1 - 1.5e-20 73.2 0.0 4e-20 71.8 0.0 1.7 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.18 CCF42643.1 - 4.7e-17 62.0 0.0 8.9e-17 61.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CCF42643.1 - 3.9e-05 22.9 0.0 7.3e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 CCF42643.1 - 9.5e-05 22.2 0.0 0.00015 21.6 0.0 1.4 1 0 0 1 1 1 1 Dynamin family Miro PF08477.8 CCF42643.1 - 0.0076 16.7 0.0 0.028 14.9 0.0 1.9 2 0 0 2 2 2 1 Miro-like protein DUF258 PF03193.11 CCF42643.1 - 0.017 14.2 0.0 0.033 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ABC_tran PF00005.22 CCF42643.1 - 0.031 14.5 0.0 0.075 13.3 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_10 PF12846.2 CCF42643.1 - 0.13 11.6 0.0 0.24 10.8 0.0 1.6 1 1 0 1 1 1 0 AAA-like domain AAA_24 PF13479.1 CCF42643.1 - 0.15 11.5 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ribosomal_L28e PF01778.12 CCF42644.1 - 2.2e-31 108.6 1.4 2.8e-31 108.3 1.0 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family ketoacyl-synt PF00109.21 CCF42645.1 - 1e-75 254.5 0.0 2.9e-75 253.0 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 CCF42645.1 - 2.2e-56 191.5 0.2 4.9e-56 190.3 0.2 1.5 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.1 CCF42645.1 - 4.9e-46 157.2 0.0 8.3e-46 156.4 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.17 CCF42645.1 - 1.2e-29 102.5 0.1 3e-29 101.2 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.5 CCF42645.1 - 3.7e-23 82.1 0.4 8.1e-18 64.7 0.0 2.9 1 1 1 2 2 2 2 KR domain adh_short PF00106.20 CCF42645.1 - 1e-17 64.5 5.5 1.3e-15 57.6 0.0 3.4 2 1 1 3 3 3 2 short chain dehydrogenase Thiolase_N PF00108.18 CCF42645.1 - 0.00093 18.2 0.0 0.0021 17.1 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_12 PF08242.7 CCF42645.1 - 0.0012 19.3 0.0 0.0031 17.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.20 CCF42645.1 - 0.01 16.0 0.0 0.029 14.6 0.0 1.8 1 0 0 1 1 1 0 Phosphopantetheine attachment site Methyltransf_18 PF12847.2 CCF42645.1 - 0.015 15.8 0.0 0.062 13.8 0.0 2.1 2 0 0 2 2 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 CCF42645.1 - 0.021 14.5 0.0 0.097 12.3 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.1 CCF42645.1 - 0.043 13.4 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Lipase_GDSL PF00657.17 CCF42646.1 - 2.4e-11 43.9 0.4 3.2e-11 43.5 0.3 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase CBM_1 PF00734.13 CCF42646.1 - 7.5e-10 38.3 16.4 7.5e-10 38.3 11.3 2.5 3 0 0 3 3 3 1 Fungal cellulose binding domain Sporozoite_P67 PF05642.6 CCF42646.1 - 0.96 7.2 12.7 1.4 6.7 8.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen ESX-1_EspG PF14011.1 CCF42647.1 - 0.012 14.8 0.1 0.013 14.7 0.1 1.1 1 0 0 1 1 1 0 EspG family AMP-binding PF00501.23 CCF42648.1 - 5.7e-42 143.5 0.0 7e-42 143.2 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme p450 PF00067.17 CCF42649.1 - 1.7e-49 168.6 0.0 6e-49 166.8 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 AcetylCoA_hydro PF02550.10 CCF42649.1 - 0.032 14.0 0.0 0.053 13.2 0.0 1.3 1 0 0 1 1 1 0 Acetyl-CoA hydrolase/transferase N-terminal domain Polyketide_cyc2 PF10604.4 CCF42650.1 - 3.1e-05 24.1 0.0 3.7e-05 23.9 0.0 1.3 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Sugar_tr PF00083.19 CCF42651.1 - 1.9e-30 105.8 26.3 9e-30 103.6 18.2 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF42651.1 - 1.6e-28 99.4 32.5 3.6e-24 85.1 7.9 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily PIRT PF15099.1 CCF42651.1 - 0.027 13.6 0.6 0.027 13.6 0.4 1.9 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family Peptidase_A8 PF01252.13 CCF42651.1 - 4.5 6.8 7.1 0.85 9.2 1.5 2.4 3 1 0 3 3 3 0 Signal peptidase (SPase) II AMP-binding PF00501.23 CCF42652.1 - 3.2e-29 101.5 0.0 7.3e-28 97.0 0.0 2.0 2 0 0 2 2 2 2 AMP-binding enzyme PP-binding PF00550.20 CCF42652.1 - 0.00017 21.7 0.1 0.00043 20.4 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site JAB PF01398.16 CCF42653.1 - 0.0083 15.8 0.4 0.069 12.9 0.3 2.3 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease GDE_N PF12439.3 CCF42653.1 - 0.042 13.0 1.1 6.1 6.0 0.2 2.3 2 0 0 2 2 2 0 Glycogen debranching enzyme N terminal TrbM PF07424.6 CCF42653.1 - 0.082 12.8 0.0 0.18 11.7 0.0 1.6 2 0 0 2 2 2 0 TrbM CorA PF01544.13 CCF42654.1 - 6.6e-28 97.5 0.2 7.7e-28 97.3 0.2 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Peptidase_M14 PF00246.19 CCF42655.1 - 1e-64 218.8 0.0 1.6e-64 218.2 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase Vps23_core PF09454.5 CCF42656.1 - 0.055 13.0 0.0 0.092 12.3 0.0 1.3 1 0 0 1 1 1 0 Vps23 core domain TFIIA PF03153.8 CCF42656.1 - 1.6 8.5 6.9 2 8.1 4.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 CCF42656.1 - 9.9 4.2 21.2 12 3.9 14.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Fungal_trans PF04082.13 CCF42657.1 - 2.4e-39 134.8 0.4 2.4e-39 134.8 0.3 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain AMP-binding PF00501.23 CCF42658.1 - 3.2e-46 157.5 0.0 4.7e-46 157.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF42658.1 - 0.00085 20.2 0.0 0.0016 19.3 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Apc3 PF12895.2 CCF42659.1 - 6.2e-28 96.7 16.9 4.5e-21 74.7 0.3 6.0 4 2 3 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.23 CCF42659.1 - 4.1e-24 83.1 10.9 2.9e-05 23.4 0.3 9.6 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_11 PF13414.1 CCF42659.1 - 2.4e-22 78.3 22.3 1.3e-07 31.1 0.0 8.0 6 1 1 8 8 8 6 TPR repeat TPR_2 PF07719.12 CCF42659.1 - 4.5e-21 73.0 22.4 0.00073 19.2 0.1 10.4 12 0 0 12 12 11 6 Tetratricopeptide repeat TPR_19 PF14559.1 CCF42659.1 - 1.8e-19 69.8 16.8 0.0017 18.6 0.1 8.4 6 3 2 9 9 9 6 Tetratricopeptide repeat TPR_12 PF13424.1 CCF42659.1 - 4.2e-18 65.0 18.5 0.00095 19.0 0.0 8.8 5 3 4 9 9 9 5 Tetratricopeptide repeat TPR_8 PF13181.1 CCF42659.1 - 6.1e-13 47.5 2.6 0.014 15.1 0.3 8.6 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_14 PF13428.1 CCF42659.1 - 1.2e-12 47.2 16.8 0.28 11.9 0.1 9.9 5 2 6 11 11 11 4 Tetratricopeptide repeat TPR_16 PF13432.1 CCF42659.1 - 6.1e-11 42.6 21.3 0.044 14.4 0.5 7.8 5 3 1 7 7 7 3 Tetratricopeptide repeat TPR_10 PF13374.1 CCF42659.1 - 3.2e-09 36.4 2.8 4.1 7.4 0.0 7.9 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_7 PF13176.1 CCF42659.1 - 6.6e-08 31.7 16.8 0.8 9.6 0.0 8.7 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_17 PF13431.1 CCF42659.1 - 4.4e-06 26.4 2.6 8.4 6.8 0.0 7.6 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_6 PF13174.1 CCF42659.1 - 6.1e-05 23.2 10.1 1.3 9.6 0.1 7.5 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_15 PF13429.1 CCF42659.1 - 0.00047 19.3 6.4 0.17 10.8 0.0 5.6 2 2 1 6 6 6 1 Tetratricopeptide repeat TPR_4 PF07721.9 CCF42659.1 - 0.00055 20.1 0.6 1.8 9.1 0.0 5.4 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_9 PF13371.1 CCF42659.1 - 0.032 14.0 9.9 8.9 6.2 0.0 5.5 7 0 0 7 7 6 0 Tetratricopeptide repeat Hexapep PF00132.19 CCF42660.1 - 1.4e-08 33.8 0.2 6.8e-05 22.2 0.1 2.6 2 0 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 CCF42660.1 - 0.00043 20.3 0.0 0.00085 19.4 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.18 CCF42660.1 - 0.078 12.2 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Nucleotidyl transferase Hexapep_2 PF14602.1 CCF42660.1 - 0.13 11.8 7.1 0.21 11.1 0.2 3.3 2 2 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase Anophelin PF10731.4 CCF42660.1 - 2 8.5 5.9 4 7.5 4.1 1.5 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito TruB_C PF09142.6 CCF42661.1 - 1.2 8.8 5.7 0.3 10.7 1.3 1.9 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal Aldolase_II PF00596.16 CCF42663.1 - 2.2e-25 89.3 0.3 2.9e-25 88.9 0.2 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Ketoacyl-synt_C PF02801.17 CCF42663.1 - 0.092 12.6 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain Glyco_hydro_cc PF11790.3 CCF42664.1 - 1.4e-10 41.0 0.0 1.6e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Ras PF00071.17 CCF42665.1 - 1.8e-59 199.7 0.3 2.1e-59 199.5 0.2 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF42665.1 - 6e-19 68.6 0.0 8.6e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CCF42665.1 - 2.4e-08 33.4 0.0 2.6e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 CCF42665.1 - 3.2e-07 29.9 0.1 1.5e-06 27.8 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CCF42665.1 - 0.0017 18.2 0.0 0.0025 17.7 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CCF42665.1 - 0.0023 17.2 0.0 0.0044 16.3 0.0 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.7 CCF42665.1 - 0.011 14.9 0.1 0.015 14.4 0.1 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF258 PF03193.11 CCF42665.1 - 0.04 13.1 0.1 0.09 11.9 0.1 1.7 2 1 0 2 2 2 0 Protein of unknown function, DUF258 ATP_bind_1 PF03029.12 CCF42665.1 - 0.055 13.0 2.1 0.48 9.9 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein DUF3500 PF12006.3 CCF42666.1 - 2.4e-104 348.6 0.0 2.8e-104 348.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3500) Rubis-subs-bind PF09273.6 CCF42668.1 - 1.7e-15 57.0 0.4 3.5e-15 56.0 0.3 1.6 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.23 CCF42668.1 - 9.6e-08 32.4 0.0 2.2e-07 31.2 0.0 1.6 2 0 0 2 2 2 1 SET domain Gate PF07670.9 CCF42669.1 - 0.53 10.2 9.3 0.023 14.5 0.8 2.8 2 2 0 2 2 2 0 Nucleoside recognition DUF4492 PF14899.1 CCF42669.1 - 5.1 6.6 8.2 2.1 7.9 1.4 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4492) zf-Nse PF11789.3 CCF42670.1 - 4.4e-18 64.5 0.7 8.1e-18 63.6 0.1 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 CCF42670.1 - 0.0015 18.1 0.2 0.0038 16.8 0.1 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Sec2p PF06428.6 CCF42670.1 - 0.027 14.3 3.4 1.5 8.7 0.0 2.7 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p Geminin PF07412.7 CCF42670.1 - 0.071 12.7 2.9 0.88 9.2 0.0 2.3 2 0 0 2 2 2 0 Geminin DUF2312 PF10073.4 CCF42670.1 - 0.17 11.2 2.4 6.5 6.1 0.1 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2312) zf-C3HC4_4 PF15227.1 CCF42670.1 - 0.19 11.5 0.1 0.4 10.5 0.1 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Fib_alpha PF08702.5 CCF42670.1 - 0.3 11.2 1.8 3.6 7.6 0.0 2.7 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Rootletin PF15035.1 CCF42670.1 - 0.35 10.8 11.6 0.093 12.7 1.7 2.9 3 0 0 3 3 3 0 Ciliary rootlet component, centrosome cohesion Baculo_PEP_C PF04513.7 CCF42670.1 - 0.39 10.5 1.7 34 4.2 0.1 3.4 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Zn_clus PF00172.13 CCF42671.1 - 0.34 10.8 6.1 0.75 9.7 4.2 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain SNARE PF05739.14 CCF42672.1 - 3e-13 49.2 2.8 1.6e-12 46.9 1.5 2.3 2 0 0 2 2 2 1 SNARE domain Fusion_gly PF00523.13 CCF42672.1 - 0.059 11.4 0.4 0.11 10.4 0.1 1.5 2 0 0 2 2 2 0 Fusion glycoprotein F0 ALIX_LYPXL_bnd PF13949.1 CCF42672.1 - 2.5 6.9 8.1 1.5 7.7 1.0 2.2 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV WD40 PF00400.27 CCF42673.1 - 5.2e-11 41.9 6.1 8.5e-08 31.8 0.0 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat PPTA PF01239.17 CCF42674.1 - 6e-41 136.1 8.2 3.2e-08 32.5 0.7 5.4 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat FAP PF07174.6 CCF42674.1 - 0.33 10.2 13.1 0.55 9.4 9.1 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) His_Phos_2 PF00328.17 CCF42675.1 - 9.7e-05 21.8 0.0 0.0034 16.7 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Aminotran_1_2 PF00155.16 CCF42676.1 - 1e-21 77.3 0.0 1e-19 70.7 0.0 2.6 2 1 1 3 3 3 2 Aminotransferase class I and II Aminotran_5 PF00266.14 CCF42676.1 - 0.0084 14.8 0.0 0.01 14.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Fungal_trans PF04082.13 CCF42677.1 - 0.0048 15.8 0.0 0.0081 15.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Beta-lactamase PF00144.19 CCF42678.1 - 2.9e-40 138.2 0.0 4.3e-39 134.4 0.0 2.0 1 1 0 1 1 1 1 Beta-lactamase FMO-like PF00743.14 CCF42679.1 - 2e-15 55.9 0.3 3.9e-13 48.4 0.0 2.3 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 CCF42679.1 - 6.8e-15 55.6 0.0 1.4e-14 54.6 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF42679.1 - 5.8e-08 32.0 0.0 3.4e-07 29.5 0.0 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 CCF42679.1 - 1.5e-05 25.0 0.2 0.0033 17.3 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF42679.1 - 0.0001 22.2 0.0 0.074 13.0 0.0 3.4 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain PTR2 PF00854.16 CCF42681.1 - 4.2e-27 94.8 12.8 1.7e-25 89.6 6.4 3.0 1 1 1 2 2 2 2 POT family PXA PF02194.10 CCF42682.1 - 3.3e-37 127.8 1.2 3.6e-37 127.7 0.0 1.6 2 0 0 2 2 2 1 PXA domain FliJ PF02050.11 CCF42682.1 - 0.0066 16.4 3.7 0.013 15.5 2.6 1.4 1 0 0 1 1 1 1 Flagellar FliJ protein MAT_Alpha1 PF04769.7 CCF42682.1 - 0.58 9.4 3.0 1.1 8.5 0.0 2.4 3 0 0 3 3 3 0 Mating-type protein MAT alpha 1 Zn_clus PF00172.13 CCF42684.1 - 0.01 15.7 2.4 0.016 15.0 1.7 1.2 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Myco_19_kDa PF05481.7 CCF42684.1 - 0.029 14.2 0.6 0.044 13.6 0.4 1.2 1 0 0 1 1 1 0 Mycobacterium 19 kDa lipoprotein antigen DUF1880 PF08976.6 CCF42684.1 - 0.041 14.0 0.3 0.11 12.6 0.0 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF1880) ABC2_membrane PF01061.19 CCF42686.1 - 1.9e-73 246.0 47.4 7.2e-51 172.3 14.0 2.9 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.7 CCF42686.1 - 2.2e-35 120.3 2.5 3e-32 110.3 0.0 3.3 3 0 0 3 3 3 2 CDR ABC transporter ABC_tran PF00005.22 CCF42686.1 - 8.3e-17 61.7 0.0 1.4e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.1 CCF42686.1 - 5.1e-06 26.5 0.8 1.1e-05 25.5 0.1 1.8 2 0 0 2 2 2 1 AAA ATPase domain ABC2_membrane_3 PF12698.2 CCF42686.1 - 4.5e-05 22.6 10.1 4.5e-05 22.6 7.0 3.4 2 2 0 2 2 2 1 ABC-2 family transporter protein AAA_25 PF13481.1 CCF42686.1 - 6.7e-05 22.3 0.0 0.00013 21.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 CCF42686.1 - 0.00022 20.4 0.0 0.00038 19.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 cobW PF02492.14 CCF42686.1 - 0.00094 18.6 0.0 0.0016 17.9 0.0 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_21 PF13304.1 CCF42686.1 - 0.0038 17.2 0.0 0.47 10.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 CCF42686.1 - 0.0054 16.2 0.1 0.013 14.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.1 CCF42686.1 - 0.0055 16.5 0.0 0.016 15.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.14 CCF42686.1 - 0.041 13.1 0.0 1.5 7.9 0.0 2.3 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_18 PF13238.1 CCF42686.1 - 0.057 13.7 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 CCF42686.1 - 0.11 12.8 0.0 0.25 11.6 0.0 1.6 2 0 0 2 2 1 0 AAA domain AAA_22 PF13401.1 CCF42686.1 - 0.12 12.4 0.0 0.39 10.8 0.0 2.0 2 1 0 2 2 1 0 AAA domain Sel1 PF08238.7 CCF42687.1 - 3e-15 56.3 4.9 0.0002 21.8 0.1 5.4 4 1 1 5 5 5 4 Sel1 repeat WD40 PF00400.27 CCF42688.1 - 3.5e-09 36.1 0.9 1.4e-05 24.8 0.0 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat Bcl-2_3 PF15286.1 CCF42689.1 - 0.0043 17.4 0.0 0.0085 16.5 0.0 1.4 1 0 0 1 1 1 1 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like MARVEL PF01284.18 CCF42689.1 - 0.041 13.6 3.5 0.062 13.1 2.4 1.3 1 0 0 1 1 1 0 Membrane-associating domain ABA_GPCR PF12430.3 CCF42689.1 - 0.062 12.4 0.7 0.45 9.6 0.0 1.9 1 1 1 2 2 2 0 Abscisic acid G-protein coupled receptor TPR_19 PF14559.1 CCF42691.1 - 0.0098 16.2 0.0 0.014 15.7 0.0 1.4 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 CCF42691.1 - 0.011 16.3 0.1 0.019 15.6 0.0 1.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 CCF42691.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat PP-binding PF00550.20 CCF42692.1 - 0.0092 16.2 0.0 0.019 15.2 0.0 1.6 1 1 0 1 1 1 1 Phosphopantetheine attachment site Transp_cyt_pur PF02133.10 CCF42694.1 - 2e-34 118.9 14.4 2.2e-34 118.8 10.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin TMCO5 PF14992.1 CCF42695.1 - 0.02 14.0 0.5 0.023 13.8 0.4 1.1 1 0 0 1 1 1 0 TMCO5 family PAT1 PF09770.4 CCF42696.1 - 1.5e-235 784.2 19.6 2.3e-235 783.6 13.6 1.3 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Glyco_transf_15 PF01793.11 CCF42697.1 - 2.2e-145 483.7 6.0 2.7e-145 483.4 4.2 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase CDI PF02234.14 CCF42697.1 - 0.019 14.7 0.6 0.019 14.7 0.4 2.2 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor DUF4338 PF14236.1 CCF42697.1 - 0.11 11.0 0.0 0.21 10.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4338) Ribosom_S12_S23 PF00164.20 CCF42698.1 - 1.5e-40 137.3 1.1 1.9e-40 137.0 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Acyl-CoA_dh_1 PF00441.19 CCF42699.1 - 5.4e-42 143.4 3.7 8.8e-42 142.7 2.5 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 CCF42699.1 - 2.8e-28 98.7 0.2 8.1e-28 97.2 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 CCF42699.1 - 6.8e-18 63.9 0.0 1.3e-17 63.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 CCF42699.1 - 1.7e-17 63.9 0.9 2.9e-17 63.1 0.6 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.3 CCF42699.1 - 0.082 12.2 0.1 0.37 10.1 0.0 2.0 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Myelin-PO_C PF10570.4 CCF42699.1 - 0.12 12.4 0.0 0.33 11.0 0.0 1.8 1 0 0 1 1 1 0 Myelin-PO cytoplasmic C-term p65 binding region Peptidase_M14 PF00246.19 CCF42700.1 - 1.2e-74 251.3 0.1 1.4e-74 251.2 0.1 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase Aft1_HRA PF11786.3 CCF42700.1 - 0.06 13.5 0.0 0.19 12.0 0.0 1.8 1 0 0 1 1 1 0 Aft1 HRA domain Cellulase PF00150.13 CCF42701.1 - 0.0046 16.2 0.1 0.0073 15.5 0.0 1.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF1712 PF08217.6 CCF42703.1 - 2e-13 49.5 0.0 9e-13 47.3 0.0 2.0 2 1 0 2 2 2 1 Fungal domain of unknown function (DUF1712) TPR_14 PF13428.1 CCF42704.1 - 8e-07 29.1 2.6 0.0042 17.5 1.1 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 CCF42704.1 - 3.5e-05 24.3 0.3 0.00023 21.7 0.2 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 CCF42704.1 - 0.00032 20.9 0.8 0.0016 18.7 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat HrpJ PF07201.6 CCF42704.1 - 0.0017 18.3 0.6 1.2 9.0 0.1 2.4 2 0 0 2 2 2 2 HrpJ-like domain TPR_17 PF13431.1 CCF42704.1 - 0.018 15.1 0.0 0.11 12.7 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat HAT PF02184.11 CCF42704.1 - 0.031 14.0 0.0 0.031 14.0 0.0 3.1 3 0 0 3 3 3 0 HAT (Half-A-TPR) repeat TPR_7 PF13176.1 CCF42704.1 - 0.034 13.9 0.0 18 5.4 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.7 CCF42704.1 - 0.063 13.0 1.6 1.3 8.8 0.0 3.2 3 0 0 3 3 3 0 Mad3/BUB1 homology region 1 Fungal_trans_2 PF11951.3 CCF42705.1 - 1.7e-08 33.4 0.1 2.1e-08 33.1 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF42706.1 - 4.3e-09 36.1 7.5 1e-08 34.9 5.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF42706.1 - 1.7e-06 27.1 0.7 1.7e-06 27.1 0.5 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Nop PF01798.13 CCF42707.1 - 1.7e-52 176.7 0.6 4.3e-52 175.4 0.4 1.7 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 CCF42707.1 - 8.4e-25 86.3 0.1 1.5e-24 85.5 0.1 1.4 1 0 0 1 1 1 1 NOSIC (NUC001) domain DUF760 PF05542.6 CCF42707.1 - 0.069 13.3 0.0 0.22 11.7 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF760) NOP5NT PF08156.8 CCF42707.1 - 0.24 11.5 0.1 0.24 11.5 0.1 3.6 3 0 0 3 3 3 0 NOP5NT (NUC127) domain APC10 PF03256.11 CCF42709.1 - 9.1e-48 162.4 0.0 1.3e-47 161.8 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) HET PF06985.6 CCF42710.1 - 7.3e-34 116.9 0.0 1.1e-33 116.3 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) GARS_A PF01071.14 CCF42711.1 - 4.3e-75 251.5 0.0 5.8e-75 251.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.10 CCF42711.1 - 1.7e-32 111.8 0.0 3.2e-32 110.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.11 CCF42711.1 - 1.8e-27 95.2 0.2 5.2e-27 93.8 0.1 1.8 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain ATP-grasp_4 PF13535.1 CCF42711.1 - 2.2e-12 47.0 0.0 5.9e-12 45.7 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.12 CCF42711.1 - 1.1e-05 24.8 0.0 3e-05 23.4 0.0 1.7 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.8 CCF42711.1 - 4.1e-05 23.0 0.0 6.5e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.1 CCF42711.1 - 7.1e-05 21.6 0.0 0.00017 20.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.9 CCF42711.1 - 0.00063 19.6 0.0 0.0021 17.9 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain Glyco_hydro_42 PF02449.10 CCF42713.1 - 1.2e-11 44.3 0.0 1.7e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Beta-galactosidase Glyco_hydro_35 PF01301.14 CCF42713.1 - 6.6e-08 32.2 0.0 1.5e-05 24.5 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 35 Glyco_hydro_10 PF00331.15 CCF42713.1 - 0.033 13.2 0.0 0.04 12.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 DUF3295 PF11702.3 CCF42714.1 - 5.1e-136 454.6 32.6 8.2e-136 453.9 22.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3295) DUF1752 PF08550.5 CCF42714.1 - 1.2e-12 47.1 1.5 1.2e-12 47.1 1.0 1.8 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF1752) Redoxin PF08534.5 CCF42716.1 - 5.2e-06 26.0 0.0 7.4e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.1 CCF42716.1 - 1.1e-05 25.3 0.0 1.5e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.16 CCF42716.1 - 0.00024 20.7 0.0 0.00029 20.4 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family DUF2427 PF10348.4 CCF42717.1 - 5.1e-06 26.0 0.7 9.9e-06 25.0 0.2 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) Abhydrolase_6 PF12697.2 CCF42719.1 - 7.5e-32 111.0 2.9 1.3e-31 110.3 2.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF42719.1 - 5.9e-17 61.9 0.4 1.3e-16 60.9 0.3 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF42719.1 - 6.9e-12 45.3 0.0 1.8e-11 43.9 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.9 CCF42719.1 - 0.0026 16.3 0.0 0.0042 15.6 0.0 1.3 1 0 0 1 1 1 1 Ndr family Hydrolase_4 PF12146.3 CCF42719.1 - 0.0027 17.5 0.0 0.005 16.6 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase peroxidase PF00141.18 CCF42720.1 - 3.5e-25 88.8 0.0 5.3e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 Peroxidase Ribosomal_L18_c PF14204.1 CCF42723.1 - 9.8e-35 119.0 9.4 1.3e-34 118.6 6.5 1.1 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region Ribosomal_L18p PF00861.17 CCF42723.1 - 4.2e-06 26.9 0.1 4.2e-06 26.9 0.1 1.9 2 0 0 2 2 2 1 Ribosomal L18p/L5e family Uteroglobin PF01099.12 CCF42723.1 - 0.086 12.6 4.6 1 9.2 0.1 2.7 2 1 1 3 3 3 0 Uteroglobin family DUF2347 PF09804.4 CCF42723.1 - 0.092 12.0 1.2 0.11 11.7 0.8 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Transp_cyt_pur PF02133.10 CCF42724.1 - 5e-65 219.7 25.1 6.1e-65 219.4 17.4 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin S1FA PF04689.8 CCF42724.1 - 0.36 10.7 0.1 0.36 10.7 0.0 2.1 3 0 0 3 3 3 0 DNA binding protein S1FA NAD_binding_8 PF13450.1 CCF42725.1 - 2.3e-07 30.7 0.1 4.2e-07 29.8 0.1 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF42725.1 - 6.8e-05 22.8 0.3 7.3e-05 22.7 0.2 1.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF42725.1 - 9e-05 21.4 0.2 9e-05 21.4 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF42725.1 - 0.00015 20.8 1.4 0.00017 20.5 0.8 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 CCF42725.1 - 0.00097 17.7 0.1 0.0012 17.3 0.0 1.1 1 0 0 1 1 1 1 HI0933-like protein TrkA_N PF02254.13 CCF42725.1 - 0.0017 18.3 0.0 0.0023 17.9 0.0 1.3 1 0 0 1 1 1 1 TrkA-N domain FAD_binding_3 PF01494.14 CCF42725.1 - 0.0019 17.3 0.2 0.002 17.2 0.2 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.22 CCF42725.1 - 0.0027 18.0 0.4 0.0038 17.6 0.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF42725.1 - 0.0073 14.9 0.1 0.0073 14.9 0.1 1.1 1 0 0 1 1 1 1 Tryptophan halogenase GIDA PF01134.17 CCF42725.1 - 0.0084 15.0 0.3 0.0084 15.0 0.2 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.16 CCF42725.1 - 0.015 14.9 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.12 CCF42725.1 - 0.03 13.4 0.3 0.038 13.0 0.2 1.2 1 1 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.1 CCF42725.1 - 0.063 13.3 0.3 0.077 13.0 0.2 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.18 CCF42725.1 - 0.069 12.8 0.0 0.069 12.8 0.0 1.2 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Lycopene_cycl PF05834.7 CCF42725.1 - 0.11 11.4 0.2 0.12 11.2 0.2 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_oxidored PF12831.2 CCF42725.1 - 0.14 11.2 0.6 0.17 10.9 0.4 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase NmrA PF05368.8 CCF42727.1 - 2.4e-31 108.8 0.0 2.8e-31 108.5 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF42727.1 - 1.7e-11 44.4 0.1 2.4e-11 43.9 0.1 1.2 1 0 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 CCF42727.1 - 1.4e-05 25.0 0.3 2.4e-05 24.3 0.2 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF42727.1 - 3.3e-05 23.6 0.1 5.5e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF42727.1 - 4.6e-05 22.9 0.0 0.00033 20.1 0.0 2.0 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF42727.1 - 0.00023 19.9 0.0 0.00042 19.1 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.15 CCF42727.1 - 0.014 15.3 0.0 0.03 14.2 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.7 CCF42727.1 - 0.018 13.9 0.0 0.037 12.9 0.0 1.5 1 0 0 1 1 1 0 Male sterility protein Saccharop_dh PF03435.13 CCF42727.1 - 0.1 11.5 0.1 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase F-box PF00646.28 CCF42728.1 - 0.003 17.1 0.1 0.0077 15.8 0.1 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 CCF42728.1 - 0.062 13.0 0.1 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 F-box-like DOT1 PF08123.8 CCF42729.1 - 1e-73 247.0 0.0 1.4e-73 246.6 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_26 PF13659.1 CCF42729.1 - 0.0024 17.8 0.0 0.0055 16.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF42729.1 - 0.0057 16.2 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF42729.1 - 0.072 13.6 0.1 0.24 11.9 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain ATG16 PF08614.6 CCF42730.1 - 3.7e-42 144.3 23.1 4.2e-42 144.1 16.0 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) HHH_5 PF14520.1 CCF42730.1 - 0.0011 19.0 2.4 0.0024 17.9 1.7 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain PhyH PF05721.8 CCF42730.1 - 0.065 13.2 1.7 0.1 12.6 1.2 1.3 1 0 0 1 1 1 0 Phytanoyl-CoA dioxygenase (PhyH) bZIP_1 PF00170.16 CCF42730.1 - 0.091 12.7 0.0 0.091 12.7 0.0 4.1 2 1 2 4 4 4 0 bZIP transcription factor TPR_19 PF14559.1 CCF42730.1 - 0.12 12.6 3.0 0.19 12.0 1.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat SurA_N PF09312.6 CCF42730.1 - 0.12 12.1 8.6 0.054 13.3 2.9 2.4 1 1 1 2 2 2 0 SurA N-terminal domain DUF4201 PF13870.1 CCF42730.1 - 0.13 11.6 19.1 0.037 13.4 10.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) LAGLIDADG_WhiA PF14527.1 CCF42730.1 - 0.19 11.6 3.9 0.13 12.1 1.5 1.7 2 0 0 2 2 2 0 WhiA LAGLIDADG-like domain SurA_N_2 PF13623.1 CCF42730.1 - 0.24 11.3 2.0 0.41 10.6 1.4 1.3 1 0 0 1 1 1 0 SurA N-terminal domain TSC22 PF01166.13 CCF42730.1 - 0.27 11.2 9.5 1.2 9.2 0.0 3.8 2 1 3 5 5 5 0 TSC-22/dip/bun family Nup54 PF13874.1 CCF42730.1 - 0.63 9.7 17.3 0.2 11.3 2.1 2.9 2 1 1 3 3 3 0 Nucleoporin complex subunit 54 Peptidase_S46 PF10459.4 CCF42730.1 - 1 7.6 13.7 1.1 7.5 9.5 1.1 1 0 0 1 1 1 0 Peptidase S46 APG6 PF04111.7 CCF42730.1 - 1.1 8.1 18.7 0.13 11.2 9.6 1.7 2 0 0 2 2 2 0 Autophagy protein Apg6 DUF3584 PF12128.3 CCF42730.1 - 1.2 6.4 23.9 0.34 8.1 13.6 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF3584) AAA_13 PF13166.1 CCF42730.1 - 1.2 7.5 11.9 1.4 7.2 8.2 1.1 1 0 0 1 1 1 0 AAA domain Sipho_Gp157 PF05565.6 CCF42730.1 - 1.5 8.3 15.8 1.2 8.7 8.2 2.0 2 0 0 2 2 2 0 Siphovirus Gp157 Cep57_CLD_2 PF14197.1 CCF42730.1 - 1.8 8.5 23.6 3.4 7.6 0.8 4.1 3 1 1 4 4 4 0 Centrosome localisation domain of PPC89 Fez1 PF06818.10 CCF42730.1 - 2.1 8.3 20.5 0.97 9.4 9.8 2.3 1 1 1 2 2 2 0 Fez1 DUF4140 PF13600.1 CCF42730.1 - 9.8 6.6 17.5 8.7 6.8 0.8 3.4 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Vps16_C PF04840.7 CCF42732.1 - 7.5e-66 222.2 0.1 9.6e-66 221.8 0.1 1.1 1 0 0 1 1 1 1 Vps16, C-terminal region p450 PF00067.17 CCF42734.1 - 5.6e-49 166.9 0.0 7.8e-49 166.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Ldl_recept_b PF00058.12 CCF42735.1 - 0.1 12.9 0.0 5.5 7.3 0.0 2.7 3 0 0 3 3 3 0 Low-density lipoprotein receptor repeat class B E1-E2_ATPase PF00122.15 CCF42737.1 - 1.4e-53 181.2 3.6 2.3e-53 180.6 2.5 1.3 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CCF42737.1 - 6.1e-41 139.9 2.9 6.1e-41 139.9 2.0 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CCF42737.1 - 3.3e-27 96.3 0.0 8e-26 91.7 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF42737.1 - 3.4e-17 62.1 0.0 7.1e-17 61.1 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 CCF42737.1 - 5.3e-13 49.5 0.0 1.5e-12 48.1 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CCF42737.1 - 5.2e-06 26.2 0.2 0.00012 21.7 0.4 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Glycophorin_A PF01102.13 CCF42737.1 - 0.013 15.2 1.1 0.26 11.0 0.1 2.4 1 1 1 2 2 2 0 Glycophorin A DUF2849 PF11011.3 CCF42737.1 - 0.037 14.2 0.2 0.12 12.5 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2849) Dak1_2 PF13684.1 CCF42737.1 - 0.062 12.2 0.2 0.1 11.4 0.2 1.3 1 0 0 1 1 1 0 Dihydroxyacetone kinase family UPF0086 PF01868.11 CCF42739.1 - 1e-22 79.5 0.0 1.5e-22 79.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function UPF0086 MFS_1 PF07690.11 CCF42741.1 - 9.1e-14 50.9 24.3 4.9e-13 48.5 16.9 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF42741.1 - 7.3e-06 24.4 9.4 0.0059 14.8 0.2 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) DUF4538 PF15061.1 CCF42741.1 - 0.0038 16.5 1.9 0.011 14.9 1.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4538) SBF PF01758.11 CCF42743.1 - 1.4e-44 151.7 13.1 1.4e-44 151.7 9.1 1.9 3 0 0 3 3 3 1 Sodium Bile acid symporter family UBA PF00627.26 CCF42743.1 - 0.074 12.9 0.1 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 UBA/TS-N domain DUF2029 PF09594.5 CCF42746.1 - 0.0028 17.2 4.1 0.0032 17.0 2.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2029) ACC_central PF08326.7 CCF42747.1 - 4.8e-142 474.5 0.1 5.8e-142 474.2 0.1 1.0 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region TetR_C_9 PF14514.1 CCF42747.1 - 0.13 12.1 0.2 0.5 10.1 0.0 2.0 3 0 0 3 3 3 0 Transcriptional regulator, TetR, C-terminal HR_lesion PF05514.6 CCF42747.1 - 0.16 11.7 0.0 0.45 10.3 0.0 1.7 2 0 0 2 2 2 0 HR-like lesion-inducing DUF22 PF01629.11 CCF42749.1 - 0.04 13.4 0.2 0.067 12.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF22 EamA PF00892.15 CCF42750.1 - 1.4e-05 25.1 0.1 1.4e-05 25.1 0.0 1.7 2 0 0 2 2 2 1 EamA-like transporter family Mg_trans_NIPA PF05653.9 CCF42750.1 - 0.0014 17.6 0.1 0.0017 17.4 0.1 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA 7TMR-DISM_7TM PF07695.6 CCF42750.1 - 0.039 13.6 2.2 0.057 13.0 1.5 1.3 1 1 0 1 1 1 0 7TM diverse intracellular signalling Neurensin PF14927.1 CCF42750.1 - 0.056 12.8 0.2 0.084 12.2 0.1 1.6 1 1 0 1 1 1 0 Neurensin COX4_pro_2 PF07835.7 CCF42750.1 - 0.21 11.6 1.8 0.23 11.4 0.1 1.9 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV EmrE PF13536.1 CCF42750.1 - 2 8.6 8.5 0.38 10.9 2.9 1.9 2 1 1 3 3 3 0 Multidrug resistance efflux transporter vATP-synt_E PF01991.13 CCF42751.1 - 5e-65 218.4 10.1 5.7e-65 218.3 7.0 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Hydrolase PF00702.21 CCF42752.1 - 1.8e-16 61.1 0.0 1.4e-14 55.0 0.0 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 CCF42752.1 - 6.3e-13 49.3 0.0 4.5e-11 43.2 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF42752.1 - 1.1e-10 41.3 0.0 8.1e-10 38.5 0.0 2.4 2 1 1 3 3 3 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 CCF42752.1 - 0.0099 15.4 0.1 0.037 13.5 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase UPF0449 PF15136.1 CCF42752.1 - 0.12 12.5 0.1 0.28 11.4 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Pkinase PF00069.20 CCF42754.1 - 1.3e-26 93.3 0.0 1.8e-26 92.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF42754.1 - 1.1e-05 24.6 0.1 0.043 12.8 0.0 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase DUF2551 PF10826.3 CCF42754.1 - 0.049 13.5 0.0 0.099 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2551) Aa_trans PF01490.13 CCF42755.1 - 3.1e-16 58.8 6.3 4.1e-16 58.4 4.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein UvdE PF03851.9 CCF42756.1 - 8.9e-113 375.8 0.0 1.1e-112 375.5 0.0 1.1 1 0 0 1 1 1 1 UV-endonuclease UvdE Gp_dh_C PF02800.15 CCF42758.1 - 2.2e-74 248.1 0.2 3.2e-74 247.6 0.1 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 CCF42758.1 - 2.7e-60 202.7 0.2 4.5e-60 201.9 0.1 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.15 CCF42758.1 - 0.00048 20.0 0.1 0.0018 18.1 0.1 2.1 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus ADH_zinc_N PF00107.21 CCF42758.1 - 0.0028 17.2 0.1 0.0087 15.6 0.1 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 CCF42758.1 - 0.079 12.1 0.1 0.28 10.3 0.0 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF1690 PF07956.6 CCF42759.1 - 1.1e-08 35.2 1.6 6.2e-06 26.2 0.3 2.1 2 0 0 2 2 2 2 Protein of Unknown function (DUF1690) COesterase PF00135.23 CCF42760.1 - 1.3e-83 281.5 0.3 7e-77 259.3 0.1 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF42760.1 - 3.2e-14 52.9 0.0 5e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF42760.1 - 0.018 14.8 0.1 0.038 13.7 0.1 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family ADH_zinc_N PF00107.21 CCF42761.1 - 6.3e-23 80.7 0.0 1.1e-22 79.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF42761.1 - 1.5e-22 79.3 0.7 2.6e-22 78.6 0.5 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 CCF42761.1 - 9.4e-05 23.3 0.0 0.00027 21.8 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_18 PF12847.2 CCF42761.1 - 0.036 14.6 0.0 0.082 13.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain TrkA_N PF02254.13 CCF42761.1 - 0.04 13.9 0.1 0.074 13.0 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain Methyltransf_11 PF08241.7 CCF42761.1 - 0.064 13.7 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.11 CCF42761.1 - 0.095 12.2 0.1 0.55 9.7 0.0 2.2 1 1 1 2 2 2 0 Met-10+ like-protein AlaDh_PNT_C PF01262.16 CCF42761.1 - 0.11 12.1 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain p450 PF00067.17 CCF42763.1 - 2.6e-53 181.2 0.0 2.9e-53 181.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF829 PF05705.9 CCF42764.1 - 9e-49 166.3 0.0 1e-48 166.1 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Pyr_redox_3 PF13738.1 CCF42765.1 - 3.9e-24 85.8 0.0 9.5e-24 84.5 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 CCF42765.1 - 4.7e-10 38.2 0.0 8.9e-10 37.3 0.0 1.4 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.9 CCF42765.1 - 1.8e-07 31.2 0.0 3.9e-07 30.1 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF42765.1 - 3.4e-06 26.2 0.0 0.00015 20.7 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.22 CCF42765.1 - 4.8e-05 23.6 0.1 0.0053 17.1 0.0 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF42765.1 - 0.00034 19.6 1.0 0.0083 15.0 0.9 2.7 2 1 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 CCF42765.1 - 0.00043 20.2 0.0 0.005 16.8 0.0 2.7 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 CCF42765.1 - 0.00056 18.5 0.1 0.0049 15.4 0.0 2.3 3 0 0 3 3 3 1 HI0933-like protein FAD_binding_3 PF01494.14 CCF42765.1 - 0.001 18.1 0.5 0.0019 17.3 0.1 1.6 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.1 CCF42765.1 - 0.0012 18.5 1.5 6.3 6.5 1.0 3.3 2 1 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.19 CCF42765.1 - 0.0085 15.0 6.3 0.06 12.2 0.2 3.2 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CCF42765.1 - 0.028 13.2 0.3 0.068 11.9 0.2 1.6 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.13 CCF42765.1 - 0.033 14.1 0.0 0.061 13.3 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain DCX PF03607.12 CCF42765.1 - 0.04 13.5 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 Doublecortin ApbA PF02558.11 CCF42765.1 - 0.043 13.2 0.0 0.72 9.2 0.0 2.5 3 0 0 3 3 3 0 Ketopantoate reductase PanE/ApbA CPSase_L_chain PF00289.17 CCF42765.1 - 0.085 12.9 0.0 12 6.0 0.0 2.4 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, N-terminal domain AlaDh_PNT_C PF01262.16 CCF42765.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.14 CCF42765.1 - 0.17 11.0 0.0 0.35 10.0 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Cofilin_ADF PF00241.15 CCF42766.1 - 3e-16 59.4 0.0 3.4e-16 59.2 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Aspzincin_M35 PF14521.1 CCF42767.1 - 0.0014 19.1 0.0 0.0047 17.4 0.0 2.0 1 1 0 1 1 1 1 Lysine-specific metallo-endopeptidase HRXXH PF13933.1 CCF42767.1 - 0.0067 15.8 0.7 0.051 12.9 0.5 2.1 1 1 0 1 1 1 1 Putative peptidase family Pex14_N PF04695.8 CCF42767.1 - 0.082 12.9 4.0 0.21 11.6 0.5 2.4 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Polysacc_deac_1 PF01522.16 CCF42768.1 - 6.9e-32 109.6 0.1 1.2e-31 108.8 0.0 1.5 2 0 0 2 2 2 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 CCF42768.1 - 2.3e-05 23.4 0.0 0.00011 21.1 0.0 1.8 1 1 1 2 2 2 1 Glycosyl hydrolase family 57 MFS_1 PF07690.11 CCF42769.1 - 2e-39 135.3 36.6 2e-39 135.3 25.3 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily PUA PF01472.15 CCF42770.1 - 3.4e-14 52.3 0.1 1.6e-13 50.1 0.0 1.9 1 1 0 1 1 1 1 PUA domain Inhibitor_I78 PF11720.3 CCF42771.1 - 7.9e-13 47.9 0.0 1e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.13 CCF42771.1 - 0.00038 20.5 0.2 0.00051 20.1 0.1 1.4 1 1 0 1 1 1 1 Potato inhibitor I family Fn3-like PF14310.1 CCF42772.1 - 1.3e-25 89.1 0.1 1.8e-25 88.6 0.1 1.2 1 0 0 1 1 1 1 Fibronectin type III-like domain CVNH PF08881.5 CCF42773.1 - 8e-12 45.3 0.1 2.6e-11 43.6 0.1 1.9 1 1 0 1 1 1 1 CVNH domain Methyltransf_23 PF13489.1 CCF42774.1 - 1.5e-18 67.0 0.0 3.6e-18 65.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF42774.1 - 5.7e-10 39.5 0.0 1.8e-09 37.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF42774.1 - 4.1e-09 36.9 0.0 2.1e-08 34.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF42774.1 - 2.5e-08 34.3 0.0 4.9e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF42774.1 - 2.7e-08 33.5 0.0 8.6e-08 31.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF42774.1 - 1.5e-05 25.2 0.0 4.4e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF42774.1 - 5.1e-05 22.3 0.0 0.00024 20.2 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_26 PF13659.1 CCF42774.1 - 9.8e-05 22.3 0.0 0.00034 20.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 CCF42774.1 - 0.0002 20.8 0.0 0.0023 17.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.13 CCF42774.1 - 0.00069 18.8 0.0 0.0019 17.3 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.15 CCF42774.1 - 0.052 12.6 0.1 0.12 11.4 0.0 1.8 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase FtsJ PF01728.14 CCF42774.1 - 0.069 13.1 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase Aa_trans PF01490.13 CCF42777.1 - 2.2e-19 69.2 5.1 2.6e-19 68.9 3.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Claudin_2 PF13903.1 CCF42777.1 - 0.033 13.8 1.3 0.11 12.2 0.0 2.0 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Trp_Tyr_perm PF03222.8 CCF42777.1 - 0.26 10.0 6.2 0.35 9.6 4.3 1.2 1 0 0 1 1 1 0 Tryptophan/tyrosine permease family SNARE PF05739.14 CCF42779.1 - 1.7e-18 66.0 2.8 2.2e-17 62.4 0.1 2.6 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 CCF42779.1 - 9.2e-15 54.6 0.3 9.2e-15 54.6 0.2 2.8 4 0 0 4 4 4 1 Syntaxin Atg14 PF10186.4 CCF42779.1 - 0.0045 15.9 4.8 0.029 13.3 0.0 2.9 3 0 0 3 3 3 1 UV radiation resistance protein and autophagy-related subunit 14 MCPsignal PF00015.16 CCF42779.1 - 0.0099 15.4 0.3 0.0099 15.4 0.2 2.3 2 1 0 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain Baculo_PEP_C PF04513.7 CCF42779.1 - 0.01 15.6 3.4 7 6.4 0.1 3.2 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Sed5p PF11416.3 CCF42779.1 - 0.024 14.0 0.0 0.056 12.8 0.0 1.5 1 0 0 1 1 1 0 Integral membrane protein Sed5p SF-assemblin PF06705.6 CCF42779.1 - 0.026 13.6 7.2 0.073 12.2 0.9 2.5 3 0 0 3 3 3 0 SF-assemblin/beta giardin Spc7 PF08317.6 CCF42779.1 - 0.041 12.5 3.7 0.043 12.4 0.8 1.9 2 0 0 2 2 2 0 Spc7 kinetochore protein RGCC PF15151.1 CCF42779.1 - 0.24 11.8 1.8 0.61 10.5 0.1 2.3 2 0 0 2 2 2 0 Response gene to complement 32 protein family LTXXQ PF07813.7 CCF42779.1 - 0.72 10.3 6.4 9.9 6.6 0.1 3.1 3 0 0 3 3 3 0 LTXXQ motif family protein NPV_P10 PF05531.7 CCF42779.1 - 0.78 10.0 5.6 12 6.2 0.1 3.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Zip PF02535.17 CCF42780.1 - 1.2e-07 31.0 1.2 1.3e-07 30.9 0.8 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter adh_short PF00106.20 CCF42781.1 - 2.9e-07 30.5 0.0 4e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF42781.1 - 0.00016 21.5 0.0 0.00019 21.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short_C2 PF13561.1 CCF42782.1 - 2.1e-18 66.9 0.0 2.6e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF42782.1 - 1.1e-07 31.9 0.1 3.7e-07 30.2 0.1 1.8 1 1 0 1 1 1 1 short chain dehydrogenase APH PF01636.18 CCF42783.1 - 2e-09 37.5 0.0 4.4e-09 36.4 0.0 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CCF42783.1 - 0.0017 17.9 0.0 0.0026 17.3 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase He_PIG PF05345.7 CCF42783.1 - 0.24 11.4 2.4 5.5 7.0 0.8 2.6 2 0 0 2 2 2 0 Putative Ig domain p450 PF00067.17 CCF42784.1 - 5.5e-27 94.4 0.0 6.7e-27 94.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Bul1_N PF04425.7 CCF42785.1 - 0.0014 17.3 0.2 0.0032 16.0 0.1 1.6 2 0 0 2 2 2 1 Bul1 N terminus Arrestin_N PF00339.24 CCF42785.1 - 0.0024 17.6 0.2 0.019 14.7 0.2 2.2 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Bul1_C PF04426.7 CCF42785.1 - 0.0055 15.9 0.0 0.0081 15.3 0.0 1.2 1 0 0 1 1 1 1 Bul1 C terminus Sugar_tr PF00083.19 CCF42786.1 - 1.4e-66 224.9 30.5 1.7e-66 224.6 21.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF42786.1 - 8.9e-16 57.5 53.8 2e-11 43.2 14.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily HTH_Tnp_Tc5 PF03221.11 CCF42787.1 - 0.21 11.4 0.9 2.5 7.9 0.2 2.8 2 1 0 2 2 2 0 Tc5 transposase DNA-binding domain AMP-binding PF00501.23 CCF42788.1 - 8.1e-16 57.4 0.0 1.3e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.15 CCF42788.1 - 0.0061 15.4 0.1 0.011 14.6 0.1 1.3 1 0 0 1 1 1 1 Condensation domain Hydant_A_N PF05378.8 CCF42789.1 - 1.6e-06 27.7 0.0 1.7e-06 27.6 0.0 1.0 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase N-terminal region BcrAD_BadFG PF01869.15 CCF42789.1 - 0.03 13.5 0.0 0.031 13.5 0.0 1.0 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Hydantoinase_A PF01968.13 CCF42789.1 - 0.037 13.1 0.0 0.039 13.0 0.0 1.0 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase Transp_cyt_pur PF02133.10 CCF42790.1 - 4.3e-100 335.3 30.3 4.8e-100 335.1 21.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF1593 PF07632.6 CCF42791.1 - 1.2e-91 306.6 0.0 1.4e-91 306.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) Sds3 PF08598.6 CCF42793.1 - 1e-38 132.9 0.4 1.4e-38 132.4 0.3 1.2 1 0 0 1 1 1 1 Sds3-like Choline_kinase PF01633.15 CCF42794.1 - 1.8e-54 184.5 0.0 1.1e-53 181.9 0.0 1.9 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.18 CCF42794.1 - 2.6e-11 43.7 0.1 7.3e-11 42.2 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Glyco_hydro_10 PF00331.15 CCF42795.1 - 5.2e-95 318.1 0.1 6e-95 317.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Cellulase-like PF12876.2 CCF42795.1 - 0.077 13.4 0.0 0.18 12.2 0.0 1.7 1 0 0 1 1 1 0 Sugar-binding cellulase-like SoxE PF06525.6 CCF42796.1 - 2 7.6 8.0 2.2 7.5 5.5 1.0 1 0 0 1 1 1 0 Sulfocyanin (SoxE) SSP160 PF06933.6 CCF42796.1 - 2.5 5.9 14.2 2.3 6.0 9.8 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 ADH_N PF08240.7 CCF42798.1 - 4e-26 90.9 2.7 6.5e-26 90.2 1.9 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF42798.1 - 2e-15 56.5 0.0 5.6e-15 55.0 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 CCF42798.1 - 2.7e-05 23.3 0.2 4.9e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.11 CCF42798.1 - 0.018 14.4 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ABA_WDS PF02496.11 CCF42798.1 - 0.16 12.1 0.0 0.42 10.8 0.0 1.6 1 0 0 1 1 1 0 ABA/WDS induced protein Upf2 PF04050.9 CCF42801.1 - 5 6.8 9.2 5.3 6.7 6.4 1.1 1 0 0 1 1 1 0 Up-frameshift suppressor 2 Hap4_Hap_bind PF10297.4 CCF42803.1 - 2.4e-08 33.5 6.0 2.4e-08 33.5 4.2 2.3 2 0 0 2 2 2 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.16 CCF42803.1 - 2.7e-06 27.2 7.8 5.6e-06 26.2 5.2 1.6 1 1 0 1 1 1 1 bZIP transcription factor SPX PF03105.14 CCF42803.1 - 0.011 15.4 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 0 SPX domain HAUS6_N PF14661.1 CCF42803.1 - 0.046 13.0 1.4 0.075 12.3 1.0 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus RBM39linker PF15519.1 CCF42803.1 - 0.1 12.8 0.0 0.75 10.1 0.0 2.5 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein Macoilin PF09726.4 CCF42803.1 - 0.12 10.6 5.5 0.2 9.8 3.8 1.3 1 1 0 1 1 1 0 Transmembrane protein bZIP_2 PF07716.10 CCF42803.1 - 3.8 7.3 11.9 5.8 6.8 5.9 2.3 1 1 1 2 2 2 0 Basic region leucine zipper IncA PF04156.9 CCF42803.1 - 6.1 6.3 6.9 11 5.5 4.8 1.3 1 0 0 1 1 1 0 IncA protein FAD_binding_7 PF03441.9 CCF42805.1 - 7.9e-91 304.0 0.8 9.4e-91 303.8 0.6 1.1 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase adh_short PF00106.20 CCF42806.1 - 8.9e-12 45.2 0.1 5.8e-11 42.5 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF42806.1 - 6.1e-08 32.7 0.0 1e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF42806.1 - 0.0002 21.1 0.2 0.00043 19.9 0.1 1.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF42806.1 - 0.0014 18.1 0.0 0.0027 17.1 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 CCF42806.1 - 0.025 13.5 0.0 0.055 12.3 0.0 1.5 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Zn_clus PF00172.13 CCF42807.1 - 6.6e-06 25.9 9.1 1.2e-05 25.0 6.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HECT_2 PF09814.4 CCF42809.1 - 1.2e-29 103.1 0.0 1.4e-29 102.8 0.0 1.1 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Glyco_trans_1_4 PF13692.1 CCF42811.1 - 6.5e-08 32.8 0.0 1.2e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.15 CCF42811.1 - 9.7e-07 28.3 0.0 1.8e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Candida_ALS PF05792.8 CCF42812.1 - 1.1e-12 47.8 46.4 6e-06 26.2 4.9 15.6 16 0 0 16 16 16 9 Candida agglutinin-like (ALS) Actin PF00022.14 CCF42813.1 - 1.6e-19 69.6 0.0 1.6e-18 66.3 0.0 2.1 1 1 0 1 1 1 1 Actin PI3_PI4_kinase PF00454.22 CCF42814.1 - 1.2e-49 168.9 0.1 1.8e-49 168.3 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.18 CCF42814.1 - 6.4e-37 127.3 3.2 8.7e-37 126.9 2.2 1.2 1 0 0 1 1 1 1 FAT domain FATC PF02260.15 CCF42814.1 - 1.5e-17 62.7 0.0 2.6e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 FATC domain TPR_16 PF13432.1 CCF42814.1 - 0.0058 17.2 0.1 0.018 15.6 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat Ank_2 PF12796.2 CCF42815.1 - 6.8e-20 71.2 0.1 3.4e-11 43.3 0.1 3.8 3 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF42815.1 - 1.5e-19 69.9 1.0 1.8e-08 34.6 0.0 5.9 4 2 2 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.25 CCF42815.1 - 4.4e-16 57.8 0.5 3.6e-06 26.5 0.1 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 CCF42815.1 - 1.4e-12 47.3 4.9 4.7e-08 33.0 0.2 4.3 4 1 0 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF42815.1 - 5.5e-10 38.4 1.8 0.047 13.9 0.0 5.7 6 0 0 6 6 6 2 Ankyrin repeat Pkinase PF00069.20 CCF42816.1 - 3.7e-30 104.9 0.0 4.6e-30 104.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF42816.1 - 3.8e-14 52.3 0.0 7e-14 51.5 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 CCF42816.1 - 0.088 11.5 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF3449 PF11931.3 CCF42817.1 - 2.5e-65 219.6 0.0 2.9e-65 219.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) DUF951 PF06107.6 CCF42817.1 - 0.01 15.3 0.1 0.022 14.2 0.0 1.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF951) MFS_1 PF07690.11 CCF42819.1 - 5e-35 120.8 27.6 1.4e-34 119.3 19.4 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF3169 PF11368.3 CCF42819.1 - 0.028 13.6 0.0 0.085 12.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Chromo PF00385.19 CCF42821.1 - 4.2e-11 42.3 8.7 8.6e-08 31.7 0.7 2.5 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain PWWP PF00855.12 CCF42821.1 - 0.055 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 PWWP domain AT_hook PF02178.14 CCF42821.1 - 0.5 10.2 30.4 0.073 12.7 3.8 3.7 3 0 0 3 3 3 0 AT hook motif Abhydrolase_6 PF12697.2 CCF42822.1 - 8.5e-17 61.7 0.0 1.3e-16 61.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF42822.1 - 7.1e-08 32.2 0.0 1e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF42822.1 - 3.8e-06 26.7 0.0 8e-06 25.6 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family NUDIX PF00293.23 CCF42823.1 - 4.7e-20 71.6 0.2 5.6e-20 71.3 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain TetR_C_9 PF14514.1 CCF42827.1 - 0.1 12.4 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator, TetR, C-terminal NBP1 PF08537.5 CCF42827.1 - 2.5 7.2 11.8 3.7 6.6 8.1 1.3 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 2OG-FeII_Oxy_3 PF13640.1 CCF42828.1 - 0.025 15.0 0.4 0.11 12.9 0.3 2.0 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily AAA_18 PF13238.1 CCF42829.1 - 6.1e-10 39.5 0.0 1e-09 38.7 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CCF42829.1 - 0.00015 22.5 0.0 0.00024 21.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CCF42829.1 - 0.00065 19.6 0.0 0.00086 19.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 CCF42829.1 - 0.03 14.0 0.0 1.7 8.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) CPT PF07931.7 CCF42829.1 - 0.085 12.4 0.1 0.2 11.2 0.1 1.9 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein DDE_1 PF03184.14 CCF42830.1 - 9.2e-51 172.0 0.0 1.3e-50 171.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Viral_NABP PF05515.6 CCF42830.1 - 0.0083 16.3 0.4 0.015 15.5 0.3 1.4 1 0 0 1 1 1 1 Viral nucleic acid binding Mg_chelatase PF01078.16 CCF42830.1 - 0.035 13.2 0.1 0.057 12.5 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ResIII PF04851.10 CCF42830.1 - 0.049 13.4 0.4 0.14 11.9 0.1 1.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit zf-CCHC PF00098.18 CCF42830.1 - 0.12 12.3 3.2 0.29 11.1 2.2 1.7 1 0 0 1 1 1 0 Zinc knuckle Sec15 PF04091.7 CCF42831.1 - 2.3e-119 398.3 4.1 2.3e-119 398.3 2.8 1.9 3 0 0 3 3 3 1 Exocyst complex subunit Sec15-like DUF4201 PF13870.1 CCF42831.1 - 0.00071 19.0 7.0 0.00071 19.0 4.9 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) COG2 PF06148.6 CCF42831.1 - 3.5 7.5 15.8 0.043 13.6 2.5 3.5 3 1 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 RRM_2 PF04059.7 CCF42833.1 - 3.2e-39 132.8 0.4 4.4e-39 132.3 0.3 1.2 1 0 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.17 CCF42833.1 - 0.056 13.0 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sad1_UNC PF07738.8 CCF42834.1 - 5.9e-37 126.4 0.0 9.2e-37 125.8 0.0 1.3 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal AFG1_ATPase PF03969.11 CCF42835.1 - 7.8e-96 321.0 0.0 8e-91 304.5 0.0 2.0 2 0 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.1 CCF42835.1 - 9.2e-07 29.0 0.4 0.0077 16.2 0.0 3.2 2 1 0 3 3 3 2 AAA ATPase domain Bac_DnaA PF00308.13 CCF42835.1 - 9.4e-06 25.4 0.9 0.072 12.7 0.0 2.7 2 1 0 2 2 2 2 Bacterial dnaA protein Sigma54_activ_2 PF14532.1 CCF42835.1 - 0.00014 21.9 0.0 0.0087 16.1 0.0 2.7 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_5 PF07728.9 CCF42835.1 - 0.0039 16.9 0.0 0.009 15.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 CCF42835.1 - 0.0042 17.2 0.0 0.017 15.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 CCF42835.1 - 0.0098 16.0 0.0 0.03 14.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 CCF42835.1 - 0.034 14.3 0.0 0.096 12.8 0.0 1.9 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.7 CCF42835.1 - 0.037 13.6 0.0 0.15 11.7 0.0 1.9 2 0 0 2 2 2 0 NACHT domain PIF1 PF05970.9 CCF42835.1 - 0.11 11.3 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase DUF1295 PF06966.7 CCF42836.1 - 1.8e-17 63.4 0.1 2.5e-17 62.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ERG4_ERG24 PF01222.12 CCF42836.1 - 3.3e-08 32.5 0.6 4.8e-08 31.9 0.4 1.3 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family ICMT PF04140.9 CCF42836.1 - 0.014 15.5 0.0 0.027 14.6 0.0 1.5 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 CCF42836.1 - 0.03 14.4 0.1 0.066 13.3 0.1 1.6 1 0 0 1 1 1 0 Phospholipid methyltransferase Permease PF02405.11 CCF42836.1 - 0.034 13.6 0.5 0.26 10.7 0.0 2.2 1 1 1 2 2 2 0 Permease Steroid_dh PF02544.11 CCF42836.1 - 0.073 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 3-oxo-5-alpha-steroid 4-dehydrogenase Peptidase_M28 PF04389.12 CCF42837.1 - 1.6e-26 93.1 0.1 2.9e-26 92.2 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 CCF42837.1 - 8.4e-05 22.1 0.0 0.00014 21.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 DSPc PF00782.15 CCF42838.1 - 2e-08 33.9 0.0 5.2e-07 29.3 0.0 2.1 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain End3 PF12761.2 CCF42840.1 - 5.2e-74 248.1 2.9 7e-74 247.7 2.0 1.2 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.2 CCF42840.1 - 1.8e-48 162.5 0.0 1.6e-47 159.5 0.0 2.2 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_8 PF13833.1 CCF42840.1 - 6.7e-07 28.8 0.1 1.3e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 CCF42840.1 - 7.4e-07 28.0 0.2 1.7e-06 26.8 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 CCF42840.1 - 0.00012 22.1 0.0 0.00048 20.2 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 CCF42840.1 - 0.00067 19.3 0.2 0.0027 17.4 0.1 2.1 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.1 CCF42840.1 - 0.004 16.4 0.1 0.013 14.7 0.1 2.0 1 0 0 1 1 1 1 EF hand MDMPI_N PF11716.3 CCF42840.1 - 0.025 14.9 0.3 0.18 12.2 0.0 2.2 2 0 0 2 2 2 0 Mycothiol maleylpyruvate isomerase N-terminal domain Mnd1 PF03962.10 CCF42840.1 - 0.031 13.9 5.4 0.056 13.1 3.8 1.4 1 0 0 1 1 1 0 Mnd1 family AKNA PF12443.3 CCF42840.1 - 0.26 11.3 2.6 1.3 9.0 0.1 2.3 2 0 0 2 2 2 0 AT-hook-containing transcription factor FlxA PF14282.1 CCF42840.1 - 0.29 11.0 2.5 2.5 8.1 0.1 2.4 1 1 0 2 2 2 0 FlxA-like protein TBPIP PF07106.8 CCF42840.1 - 0.67 9.4 9.9 2.4 7.6 4.2 2.2 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Vfa1 PF08432.5 CCF42840.1 - 0.91 9.5 4.0 1.7 8.6 2.8 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Lge1 PF11488.3 CCF42840.1 - 1.2 9.4 8.2 0.78 9.9 2.0 2.6 2 1 0 2 2 2 0 Transcriptional regulatory protein LGE1 COG2 PF06148.6 CCF42840.1 - 1.8 8.4 6.2 1.1 9.1 0.5 2.3 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 TPR_MLP1_2 PF07926.7 CCF42840.1 - 3.2 7.4 9.7 0.38 10.4 0.3 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Pyr_redox_2 PF07992.9 CCF42841.1 - 5.2e-18 65.6 0.0 1.1e-17 64.6 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF42841.1 - 4.6e-07 30.1 0.9 2.2e-06 27.9 0.3 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF42841.1 - 0.00072 18.5 0.3 3.4 6.4 0.0 3.7 3 1 1 4 4 4 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 CCF42841.1 - 0.0017 18.4 0.1 0.018 15.1 0.0 2.4 1 1 2 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF42841.1 - 0.0019 17.9 0.0 2.3 7.9 0.0 3.5 4 0 0 4 4 4 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 CCF42841.1 - 0.0048 16.8 0.0 4.4 7.4 0.0 2.4 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 CCF42841.1 - 0.0059 15.5 0.1 0.45 9.3 0.0 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein HI0933_like PF03486.9 CCF42841.1 - 0.02 13.4 0.1 0.26 9.7 0.0 2.7 3 1 1 4 4 4 0 HI0933-like protein Thi4 PF01946.12 CCF42841.1 - 0.038 13.0 0.3 0.7 8.9 0.1 2.4 2 0 0 2 2 2 0 Thi4 family K_oxygenase PF13434.1 CCF42841.1 - 0.055 12.3 0.0 0.12 11.3 0.0 1.4 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) ACBP PF00887.14 CCF42842.1 - 4.4e-25 87.1 0.4 5.1e-25 86.9 0.3 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein Tyr-DNA_phospho PF06087.7 CCF42843.1 - 1.4e-137 458.9 0.0 1.6e-137 458.7 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.1 CCF42843.1 - 7.5e-05 22.4 0.1 0.042 13.5 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain WD40 PF00400.27 CCF42845.1 - 2.4e-07 30.3 0.5 0.009 15.8 0.0 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat CLTH PF10607.4 CCF42845.1 - 1.3e-05 24.9 0.2 1.8e-05 24.4 0.2 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain Peptidase_M8 PF01457.11 CCF42845.1 - 0.16 10.2 0.0 0.21 9.8 0.0 1.1 1 0 0 1 1 1 0 Leishmanolysin CAP PF00188.21 CCF42846.1 - 5.2e-20 72.1 0.7 8.4e-20 71.5 0.5 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Nop PF01798.13 CCF42847.1 - 2e-57 192.7 0.2 3.7e-57 191.8 0.2 1.4 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 CCF42847.1 - 9.8e-22 76.5 0.0 2.1e-21 75.4 0.0 1.6 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 CCF42847.1 - 7.8e-19 67.6 0.0 7.8e-19 67.6 0.0 2.4 2 0 0 2 2 2 1 NOP5NT (NUC127) domain RNA_polI_A34 PF08208.6 CCF42847.1 - 0.00018 21.2 21.1 0.0003 20.5 14.6 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 Autotransporter PF03797.14 CCF42847.1 - 0.00054 19.3 0.1 0.00085 18.7 0.1 1.2 1 0 0 1 1 1 1 Autotransporter beta-domain GAGA_bind PF06217.7 CCF42847.1 - 1.8 8.4 9.9 2.9 7.7 6.9 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family DDHD PF02862.12 CCF42847.1 - 3.8 7.2 6.9 7.2 6.3 4.8 1.5 1 0 0 1 1 1 0 DDHD domain V_ATPase_I PF01496.14 CCF42848.1 - 0.19 9.5 4.8 0.29 8.9 3.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MFS_1 PF07690.11 CCF42850.1 - 8e-38 130.0 19.6 8e-38 130.0 13.6 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Phage_holin_3 PF05106.7 CCF42850.1 - 0.15 12.0 2.6 0.41 10.6 0.3 2.7 2 0 0 2 2 2 0 Phage holin family (Lysis protein S) DUF1049 PF06305.6 CCF42850.1 - 0.34 10.4 2.1 6.7 6.2 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1049) AAA_17 PF13207.1 CCF42851.1 - 0.00024 21.9 0.0 0.00099 19.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.15 CCF42851.1 - 0.002 17.8 0.0 0.0033 17.1 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.1 CCF42851.1 - 0.0028 17.5 0.0 0.0052 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF42851.1 - 0.0047 16.9 0.0 0.0074 16.2 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.7 CCF42851.1 - 0.0068 15.5 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin Torsin PF06309.6 CCF42851.1 - 0.025 14.4 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 Torsin ArgK PF03308.11 CCF42851.1 - 0.11 11.2 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 ArgK protein Iso_dh PF00180.15 CCF42852.1 - 2.3e-35 122.1 0.0 2.6e-35 122.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Ank_2 PF12796.2 CCF42853.1 - 2.3e-48 162.4 1.1 2.8e-14 53.1 0.0 3.9 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 CCF42853.1 - 7.9e-33 110.6 4.2 2.7e-08 33.2 0.0 7.3 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.1 CCF42853.1 - 7.6e-27 92.7 1.4 7e-07 29.2 0.0 6.3 3 1 3 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF42853.1 - 3.5e-25 85.5 3.0 6.3e-06 25.9 0.0 7.0 8 0 0 8 8 8 5 Ankyrin repeat Ank_4 PF13637.1 CCF42853.1 - 4.2e-24 84.4 0.7 2.9e-08 33.9 0.0 4.9 3 2 1 5 5 5 3 Ankyrin repeats (many copies) SAP PF02037.22 CCF42853.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 SAP domain Ank_2 PF12796.2 CCF42854.1 - 8.4e-28 96.5 0.0 6.1e-12 45.7 0.0 4.6 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 CCF42854.1 - 7.2e-19 66.5 3.8 0.0059 16.3 0.0 7.3 7 0 0 7 7 7 5 Ankyrin repeat Ank_4 PF13637.1 CCF42854.1 - 8.4e-16 58.0 1.1 0.036 14.5 0.0 5.8 4 1 2 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF42854.1 - 6.2e-15 53.8 0.4 0.034 14.3 0.0 7.8 8 0 0 8 8 7 3 Ankyrin repeat Ank_5 PF13857.1 CCF42854.1 - 3.8e-10 39.6 2.2 0.0043 17.2 0.0 5.3 3 1 3 6 6 6 2 Ankyrin repeats (many copies) NACHT PF05729.7 CCF42854.1 - 0.00047 19.8 0.0 0.0017 18.0 0.0 1.9 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.1 CCF42854.1 - 0.0032 17.6 0.0 0.0094 16.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 CCF42854.1 - 0.005 17.0 0.0 0.02 15.0 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF42854.1 - 0.013 15.5 0.0 0.095 12.6 0.0 2.4 2 1 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.1 CCF42854.1 - 0.039 13.7 0.0 0.16 11.7 0.0 2.0 2 0 0 2 2 2 0 Part of AAA domain AAA_17 PF13207.1 CCF42854.1 - 0.061 14.1 0.0 0.21 12.4 0.0 2.0 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 CCF42854.1 - 0.16 12.1 0.0 0.44 10.7 0.0 1.8 1 0 0 1 1 1 0 RNA helicase MaoC_dehydrat_N PF13452.1 CCF42854.1 - 0.17 11.7 0.0 0.39 10.4 0.0 1.6 1 0 0 1 1 1 0 N-terminal half of MaoC dehydratase PhoH PF02562.11 CCF42854.1 - 0.18 10.9 0.0 0.42 9.8 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein IstB_IS21 PF01695.12 CCF42854.1 - 0.19 11.1 0.0 0.38 10.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein XPG_N PF00752.12 CCF42855.1 - 1e-31 109.1 0.0 2.8e-31 107.7 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 CCF42855.1 - 4.8e-30 103.4 0.6 8e-30 102.7 0.0 1.7 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.15 CCF42855.1 - 2.7e-05 24.3 0.2 0.00019 21.5 0.0 2.4 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold HHH_2 PF12826.2 CCF42855.1 - 0.04 13.8 0.0 0.12 12.2 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif XPG_I_2 PF12813.2 CCF42855.1 - 0.079 12.4 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 XPG domain containing Acyl-CoA_dh_M PF02770.14 CCF42856.1 - 6.4e-21 73.6 0.2 1.2e-20 72.7 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Cyt-b5 PF00173.23 CCF42856.1 - 1.8e-20 72.4 0.2 3.5e-20 71.5 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_N PF02771.11 CCF42856.1 - 4.7e-17 62.5 0.0 8.3e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Ribosomal_60s PF00428.14 CCF42856.1 - 0.053 13.9 2.4 0.1 13.0 1.7 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Cys_rich_VLP PF14194.1 CCF42856.1 - 0.12 12.1 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Cysteine-rich VLP Rad60-SLD_2 PF13881.1 CCF42857.1 - 6.2e-12 45.3 0.0 1.5e-11 44.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 CCF42857.1 - 1.1e-05 24.6 0.0 1.9e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.4 CCF42857.1 - 0.0009 19.3 0.3 0.0024 18.0 0.0 1.8 2 1 0 2 2 2 1 DUF2407 ubiquitin-like domain Mitofilin PF09731.4 CCF42857.1 - 0.12 11.0 5.5 0.12 11.0 3.8 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Herpes_TAF50 PF03326.8 CCF42857.1 - 5.3 5.8 13.9 6.3 5.6 9.6 1.1 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) Dicty_REP PF05086.7 CCF42857.1 - 5.4 4.6 7.2 6.7 4.3 5.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3827 PF12877.2 CCF42857.1 - 7.9 4.4 11.0 11 4.0 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) CBFD_NFYB_HMF PF00808.18 CCF42858.1 - 4.8e-11 42.5 0.1 8.7e-11 41.7 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 CCF42858.1 - 0.00021 21.3 0.0 0.00038 20.5 0.0 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIIA PF03153.8 CCF42858.1 - 0.0013 18.7 19.4 0.0018 18.2 13.4 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF1983 PF09327.6 CCF42858.1 - 0.33 10.9 3.9 0.91 9.5 2.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1983) Sigma70_ner PF04546.8 CCF42858.1 - 5.9 6.4 21.1 15 5.1 14.6 1.7 1 0 0 1 1 1 0 Sigma-70, non-essential region eIF-3c_N PF05470.7 CCF42858.1 - 8.6 4.3 13.7 16 3.4 9.5 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Peptidase_S24 PF00717.18 CCF42859.1 - 0.00058 19.4 0.1 0.0018 17.8 0.0 1.8 1 1 0 1 1 1 1 Peptidase S24-like Stm1_N PF09598.5 CCF42861.1 - 2.6e-12 47.2 3.8 2.6e-12 47.2 2.6 3.8 4 2 1 5 5 5 1 Stm1 HABP4_PAI-RBP1 PF04774.10 CCF42861.1 - 0.00025 21.4 7.5 0.00025 21.4 5.2 2.6 2 1 1 3 3 3 1 Hyaluronan / mRNA binding family DUF913 PF06025.7 CCF42861.1 - 0.66 8.6 2.2 0.76 8.4 1.0 1.4 1 1 0 1 1 1 0 Domain of Unknown Function (DUF913) Phostensin PF13914.1 CCF42861.1 - 0.99 9.5 4.5 0.36 10.9 0.6 2.2 2 0 0 2 2 2 0 Phostensin PP1-binding and SH3-binding region Prefoldin_2 PF01920.15 CCF42862.1 - 0.012 15.3 2.6 0.018 14.8 1.8 1.3 1 0 0 1 1 1 0 Prefoldin subunit DUF2205 PF10224.4 CCF42862.1 - 0.024 14.1 0.7 0.024 14.1 0.5 1.0 1 0 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) Cmc1 PF08583.5 CCF42863.1 - 3.8e-15 55.4 1.9 4.6e-15 55.1 1.3 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like Tmemb_14 PF03647.8 CCF42864.1 - 1.8e-23 82.7 7.6 2e-23 82.5 5.2 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C DUF2416 PF10315.4 CCF42864.1 - 0.078 13.2 0.3 0.13 12.5 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2416) DAD PF02109.11 CCF42865.1 - 4e-14 52.6 0.1 5.2e-14 52.2 0.1 1.1 1 0 0 1 1 1 1 DAD family DUF1180 PF06679.7 CCF42865.1 - 0.0098 15.7 0.9 0.011 15.6 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) NmrA PF05368.8 CCF42866.1 - 7.4e-33 113.7 0.3 1e-32 113.2 0.2 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF42866.1 - 0.00016 21.6 0.6 0.011 15.8 0.4 2.2 1 1 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 CCF42867.1 - 1.3e-20 74.0 0.2 2.1e-20 73.3 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF42867.1 - 4.4e-18 65.9 0.0 5.7e-18 65.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF42867.1 - 1e-06 28.5 0.1 2e-06 27.6 0.1 1.5 1 1 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.14 CCF42867.1 - 0.00021 20.4 0.0 0.00076 18.5 0.0 1.8 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Eno-Rase_NADH_b PF12242.3 CCF42867.1 - 0.001 18.7 0.2 0.0023 17.6 0.2 1.5 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Epimerase PF01370.16 CCF42867.1 - 0.0032 16.9 0.0 0.0087 15.5 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF42867.1 - 0.0064 16.5 0.8 0.014 15.3 0.2 1.7 2 0 0 2 2 2 1 NADH(P)-binding RmlD_sub_bind PF04321.12 CCF42867.1 - 0.14 11.0 0.3 0.38 9.5 0.1 1.9 2 1 0 2 2 2 0 RmlD substrate binding domain P5CR_dimer PF14748.1 CCF42868.1 - 0.1 12.6 2.1 1.1 9.2 0.0 2.4 2 0 0 2 2 2 0 Pyrroline-5-carboxylate reductase dimerisation PLU-1 PF08429.6 CCF42868.1 - 0.22 10.3 3.6 0.22 10.3 1.5 1.9 2 1 0 2 2 2 0 PLU-1-like protein DUF2664 PF10867.3 CCF42868.1 - 0.35 11.5 2.2 1.1 9.9 1.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2664) zf-CCHC PF00098.18 CCF42868.1 - 0.52 10.3 9.2 0.08 12.9 3.0 2.3 2 0 0 2 2 2 0 Zinc knuckle RRM_1 PF00076.17 CCF42869.1 - 4.3e-15 55.0 0.0 6e-14 51.4 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF42869.1 - 1.1e-07 31.7 0.0 2e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF42869.1 - 0.002 17.9 0.0 0.0048 16.7 0.0 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.27 CCF42870.1 - 1.8e-07 30.7 1.1 0.0087 15.9 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat TRAM_LAG1_CLN8 PF03798.11 CCF42871.1 - 1.9e-34 118.9 18.5 2.8e-34 118.4 12.9 1.3 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.6 CCF42871.1 - 4.5e-24 83.7 0.5 1.6e-23 81.9 0.0 2.1 2 0 0 2 2 2 1 TRAM1-like protein ABC_tran PF00005.22 CCF42872.1 - 3.2e-32 111.6 0.1 1.5e-31 109.4 0.0 2.1 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.18 CCF42872.1 - 1.6e-22 80.2 9.6 1.6e-22 80.2 6.6 2.3 3 0 0 3 3 3 1 ABC transporter transmembrane region SMC_N PF02463.14 CCF42872.1 - 6.9e-06 25.4 0.1 4.4e-05 22.8 0.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF42872.1 - 0.0014 18.6 0.0 0.13 12.1 0.0 2.3 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 CCF42872.1 - 0.0032 16.6 0.0 0.0075 15.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 CCF42872.1 - 0.01 15.3 0.2 0.048 13.1 0.1 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain SbcCD_C PF13558.1 CCF42872.1 - 0.03 14.2 0.1 0.27 11.1 0.1 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF3742 PF12553.3 CCF42872.1 - 0.085 13.3 0.0 4 7.9 0.0 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3742) HLH PF00010.21 CCF42874.1 - 4.2e-13 48.7 0.1 1.1e-12 47.4 0.0 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain KAR9 PF08580.5 CCF42874.1 - 0.05 11.8 2.8 0.062 11.5 1.9 1.2 1 0 0 1 1 1 0 Yeast cortical protein KAR9 DUF826 PF05696.6 CCF42874.1 - 0.073 13.2 0.1 0.27 11.3 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF826) Ric8 PF10165.4 CCF42875.1 - 5.4e-117 391.3 0.0 6.2e-117 391.1 0.0 1.0 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn NUC130_3NT PF08158.7 CCF42875.1 - 0.17 12.2 1.8 17 5.8 0.0 3.6 4 0 0 4 4 4 0 NUC130/3NT domain Fungal_trans PF04082.13 CCF42876.1 - 2.2e-24 85.7 0.1 3.7e-24 84.9 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF42876.1 - 0.0012 18.6 6.4 0.0023 17.7 4.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Amidohydro_3 PF07969.6 CCF42877.1 - 1.1e-40 140.1 0.1 1.4e-40 139.8 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 CCF42877.1 - 9.8e-11 41.3 0.1 1.1e-09 37.9 0.0 2.5 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_4 PF13147.1 CCF42877.1 - 0.00043 20.3 0.6 0.0016 18.5 0.0 2.2 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_1 PF01979.15 CCF42877.1 - 0.00089 19.0 0.3 0.0056 16.3 0.2 2.4 1 1 0 1 1 1 1 Amidohydrolase family DUF3130 PF11328.3 CCF42877.1 - 0.071 13.1 0.0 15 5.6 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3130 DUF917 PF06032.7 CCF42878.1 - 1.5e-43 148.7 0.0 1.8e-43 148.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF917) DUF1183 PF06682.7 CCF42879.1 - 0.062 12.9 2.9 0.055 13.0 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1183) Syndecan PF01034.15 CCF42880.1 - 0.0015 18.1 0.0 0.0032 17.1 0.0 1.5 1 0 0 1 1 1 1 Syndecan domain Herpes_gE PF02480.11 CCF42880.1 - 0.048 11.9 0.0 0.061 11.5 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF1191 PF06697.7 CCF42880.1 - 0.094 11.5 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) Flu_M2 PF00599.12 CCF42880.1 - 0.16 11.8 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Influenza Matrix protein (M2) SKG6 PF08693.5 CCF42880.1 - 2.3 7.5 4.1 3.8 6.9 2.8 1.2 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Dioxygenase_C PF00775.16 CCF42883.1 - 1.2e-07 31.2 0.0 1.6e-05 24.2 0.0 2.2 1 1 1 2 2 2 2 Dioxygenase DUF615 PF04751.9 CCF42884.1 - 0.011 15.3 0.7 0.016 14.8 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF615) Nit_Regul_Hom PF10126.4 CCF42884.1 - 0.073 12.8 0.0 0.082 12.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein, homolog of nitrogen regulatory protein PII Cauli_VI PF01693.11 CCF42886.1 - 7.8e-24 83.4 1.1 2.5e-13 49.8 0.2 2.6 2 0 0 2 2 2 2 Caulimovirus viroplasmin Uma2 PF05685.7 CCF42887.1 - 0.0025 17.2 0.0 0.0049 16.2 0.0 1.4 1 0 0 1 1 1 1 Putative restriction endonuclease BAF1_ABF1 PF04684.8 CCF42887.1 - 0.44 9.3 4.8 0.62 8.8 3.3 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Glyco_hydro_61 PF03443.9 CCF42888.1 - 6.8e-13 48.9 0.3 7e-13 48.8 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DUF3602 PF12223.3 CCF42889.1 - 1.4e-08 35.0 6.6 0.00036 20.8 1.4 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3602) DUF2665 PF11654.3 CCF42892.1 - 0.086 12.4 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2665) Nucleocapsid-N PF11030.3 CCF42893.1 - 0.14 11.9 3.4 0.45 10.3 2.4 1.9 1 0 0 1 1 1 0 Nucleocapsid protein N Cupin_2 PF07883.6 CCF42894.1 - 7.7e-08 31.7 0.0 1.9e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 Cupin domain FAA_hydrolase PF01557.13 CCF42896.1 - 2.6e-62 210.1 0.0 3.3e-62 209.8 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Pkinase PF00069.20 CCF42897.1 - 3.9e-13 49.1 0.0 3.2e-12 46.1 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF42897.1 - 2.2e-10 40.0 0.0 3.2e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF42897.1 - 0.00013 21.0 0.0 0.00017 20.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like DUF1751 PF08551.5 CCF42899.1 - 8.4e-22 77.3 2.6 1.4e-21 76.6 1.8 1.4 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.17 CCF42899.1 - 0.0051 16.8 0.8 0.0089 16.0 0.2 1.6 1 1 1 2 2 2 1 Rhomboid family PALP PF00291.20 CCF42901.1 - 7.1e-13 48.4 0.0 1.2e-11 44.3 0.0 2.0 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme TauD PF02668.11 CCF42902.1 - 9.2e-22 77.9 0.0 1.1e-21 77.6 0.0 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family TilS PF09179.6 CCF42902.1 - 0.013 15.5 2.7 8.6 6.4 0.1 3.3 3 0 0 3 3 3 0 TilS substrate binding domain DUF2116 PF09889.4 CCF42903.1 - 0.26 11.1 0.1 0.26 11.1 0.1 2.8 3 0 0 3 3 3 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF843 PF05814.6 CCF42903.1 - 0.55 10.0 3.0 2.3 8.0 0.1 2.6 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) SNF PF00209.13 CCF42904.1 - 3.8e-89 299.5 32.1 1.5e-88 297.5 22.2 1.8 1 1 0 1 1 1 1 Sodium:neurotransmitter symporter family DUF4241 PF14025.1 CCF42904.1 - 0.27 10.9 1.4 0.46 10.2 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4241) Fungal_trans PF04082.13 CCF42906.1 - 5e-30 104.2 0.0 9.5e-30 103.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.11 CCF42907.1 - 0.026 13.2 8.3 0.024 13.3 5.2 1.3 1 1 0 1 1 1 0 Major Facilitator Superfamily Srg PF02118.16 CCF42907.1 - 0.098 12.0 1.6 0.12 11.8 1.1 1.0 1 0 0 1 1 1 0 Srg family chemoreceptor EF-hand_4 PF12763.2 CCF42908.1 - 1.2e-13 50.6 0.0 3e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand CENP-F_leu_zip PF10473.4 CCF42908.1 - 1.2e-06 28.4 30.0 4.7e-05 23.2 7.1 3.0 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.9 CCF42908.1 - 0.00012 21.7 30.9 0.0023 17.5 8.6 2.7 1 1 1 2 2 2 2 IncA protein ATG16 PF08614.6 CCF42908.1 - 0.00054 19.8 32.1 0.042 13.6 6.9 2.7 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) Myosin_tail_1 PF01576.14 CCF42908.1 - 0.0027 15.5 27.6 0.015 13.0 19.3 1.7 1 1 0 1 1 1 1 Myosin tail EF-hand_7 PF13499.1 CCF42908.1 - 0.0037 17.3 0.0 0.0083 16.2 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair WEMBL PF05701.6 CCF42908.1 - 0.011 14.1 23.1 0.017 13.5 16.0 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light TPR_MLP1_2 PF07926.7 CCF42908.1 - 0.02 14.6 33.4 0.25 11.0 11.9 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF869 PF05911.6 CCF42908.1 - 0.032 12.5 18.2 0.054 11.7 12.6 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) Rab5-bind PF09311.6 CCF42908.1 - 0.041 13.7 34.8 0.68 9.7 13.3 3.2 1 1 1 2 2 2 0 Rabaptin-like protein EF-hand_1 PF00036.27 CCF42908.1 - 0.046 13.0 0.0 13 5.3 0.0 2.5 2 0 0 2 2 2 0 EF hand Spc7 PF08317.6 CCF42908.1 - 0.053 12.1 26.0 0.66 8.5 6.3 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein AAA_27 PF13514.1 CCF42908.1 - 0.053 11.2 19.9 0.079 10.6 13.8 1.1 1 0 0 1 1 1 0 AAA domain GAS PF13851.1 CCF42908.1 - 0.063 12.4 29.9 0.69 9.0 12.0 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.7 CCF42908.1 - 0.081 12.7 11.8 0.014 15.1 3.7 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Mnd1 PF03962.10 CCF42908.1 - 0.092 12.4 28.2 0.39 10.3 6.7 2.3 1 1 1 2 2 2 0 Mnd1 family DUF3584 PF12128.3 CCF42908.1 - 0.094 10.0 26.1 0.15 9.3 18.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF812 PF05667.6 CCF42908.1 - 0.3 9.5 25.0 0.62 8.4 17.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF812) TMF_TATA_bd PF12325.3 CCF42908.1 - 0.31 10.7 27.1 0.08 12.6 3.1 3.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.3 CCF42908.1 - 0.36 10.6 32.6 0.27 11.0 7.4 3.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding MscS_porin PF12795.2 CCF42908.1 - 0.5 9.6 41.9 6 6.0 29.2 2.1 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain AAA_13 PF13166.1 CCF42908.1 - 0.69 8.3 20.7 1.2 7.5 14.3 1.3 1 0 0 1 1 1 0 AAA domain Reo_sigmaC PF04582.7 CCF42908.1 - 0.83 8.7 12.5 1.8 7.6 2.6 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein CALCOCO1 PF07888.6 CCF42908.1 - 0.95 7.6 18.8 1.7 6.8 13.0 1.4 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like COG2 PF06148.6 CCF42908.1 - 1 9.2 15.1 0.2 11.5 3.3 2.6 1 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Atg14 PF10186.4 CCF42908.1 - 1.6 7.5 30.1 1 8.2 7.9 2.2 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4201 PF13870.1 CCF42908.1 - 1.7 8.0 27.5 3.7 6.9 9.0 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) APG6 PF04111.7 CCF42908.1 - 1.9 7.4 31.0 0.95 8.4 10.9 2.2 1 1 1 2 2 2 0 Autophagy protein Apg6 ADIP PF11559.3 CCF42908.1 - 1.9 8.3 37.4 2.9 7.7 12.4 3.4 1 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Filament PF00038.16 CCF42908.1 - 2.2 7.6 27.9 4.5 6.6 7.4 2.6 1 1 1 2 2 2 0 Intermediate filament protein EzrA PF06160.7 CCF42908.1 - 3.2 5.8 24.2 0.71 7.9 11.7 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Lebercilin PF15619.1 CCF42908.1 - 3.4 7.0 29.0 0.14 11.5 13.2 2.1 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF3450 PF11932.3 CCF42908.1 - 4.2 6.5 28.7 3.5 6.8 6.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DivIC PF04977.10 CCF42908.1 - 4.4 6.8 33.5 0.13 11.7 3.0 4.7 1 1 3 4 4 4 0 Septum formation initiator DUF342 PF03961.8 CCF42908.1 - 4.6 5.5 24.5 0.28 9.5 5.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF342) DUF4047 PF13256.1 CCF42908.1 - 5.6 6.9 9.0 3 7.8 4.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4047) GOLGA2L5 PF15070.1 CCF42908.1 - 6 5.2 28.6 12 4.2 19.8 1.4 1 1 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 DUF2353 PF09789.4 CCF42908.1 - 6.4 5.9 23.5 7.8 5.6 15.5 1.6 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) Fib_alpha PF08702.5 CCF42908.1 - 7.6 6.6 25.4 0.32 11.1 7.3 3.0 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Tup_N PF08581.5 CCF42908.1 - 8.2 6.7 14.2 3.8 7.7 3.7 2.5 1 1 1 2 2 2 0 Tup N-terminal Cut8_M PF14483.1 CCF42910.1 - 0.055 13.2 0.1 0.098 12.4 0.1 1.4 1 0 0 1 1 1 0 Cut8 dimerisation domain PMC2NT PF08066.7 CCF42911.1 - 3.4e-21 75.3 0.1 5.2e-21 74.7 0.1 1.3 1 0 0 1 1 1 1 PMC2NT (NUC016) domain NAD_binding_6 PF08030.7 CCF42912.1 - 8.7e-17 61.4 0.0 1.2e-16 60.9 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 CCF42912.1 - 1.8e-09 37.4 0.0 3.8e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.14 CCF42912.1 - 2.4e-09 37.3 12.1 2.4e-09 37.3 8.4 2.5 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.16 CCF42912.1 - 0.02 15.4 0.0 8.8 6.9 0.0 2.6 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain DsrC PF04358.8 CCF42913.1 - 0.085 13.1 0.0 0.091 13.0 0.0 1.2 1 0 0 1 1 1 0 DsrC like protein Surfac_D-trimer PF09006.6 CCF42913.1 - 0.27 11.0 4.7 0.47 10.2 3.2 1.3 1 0 0 1 1 1 0 Lung surfactant protein D coiled-coil trimerisation CDC14 PF08045.6 CCF42914.1 - 4.1e-91 304.6 0.0 5.1e-91 304.3 0.0 1.1 1 0 0 1 1 1 1 Cell division control protein 14, SIN component Methyltransf_12 PF08242.7 CCF42916.1 - 7.4e-19 68.0 0.0 1.8e-18 66.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF42916.1 - 6.4e-11 42.8 0.0 2.5e-10 40.9 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF42916.1 - 6.9e-11 41.9 0.0 1.3e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF42916.1 - 5.2e-10 39.6 0.0 3.5e-09 37.0 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF42916.1 - 5.7e-10 39.1 0.0 1.1e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PS-DH PF14765.1 CCF42916.1 - 3.9e-07 29.5 0.1 7.1e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ubie_methyltran PF01209.13 CCF42916.1 - 1.7e-06 27.3 0.0 3.6e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family ADH_N PF08240.7 CCF42916.1 - 2.5e-06 27.2 0.1 6.2e-06 25.9 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_25 PF13649.1 CCF42916.1 - 2.7e-06 27.6 0.0 1e-05 25.8 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.21 CCF42916.1 - 8.1e-06 25.4 0.0 3e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_26 PF13659.1 CCF42916.1 - 0.001 19.0 0.0 0.0026 17.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF42916.1 - 0.025 13.9 0.0 0.093 12.0 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.14 CCF42916.1 - 0.055 13.0 0.2 0.24 10.8 0.0 2.1 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NodS PF05401.6 CCF42916.1 - 0.083 12.2 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Nodulation protein S (NodS) DUF938 PF06080.7 CCF42916.1 - 0.14 11.6 0.0 0.9 9.0 0.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF938) ATP-synt_J PF04911.7 CCF42917.1 - 1.4e-24 85.3 0.9 1.5e-24 85.1 0.6 1.0 1 0 0 1 1 1 1 ATP synthase j chain APH PF01636.18 CCF42919.1 - 3.8e-15 56.2 0.1 7.5e-15 55.3 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family AA_permease_2 PF13520.1 CCF42920.1 - 4.9e-17 61.5 7.5 5.7e-17 61.3 5.2 1.1 1 0 0 1 1 1 1 Amino acid permease zf-C2H2_4 PF13894.1 CCF42922.1 - 1.7e-08 34.1 13.2 0.077 13.3 0.2 4.8 4 0 0 4 4 4 3 C2H2-type zinc finger Peptidase_C14 PF00656.17 CCF42922.1 - 0.0034 17.1 0.2 0.016 14.9 0.1 2.0 1 1 0 1 1 1 1 Caspase domain zf-H2C2_2 PF13465.1 CCF42922.1 - 0.016 15.4 2.1 6.8 7.1 0.0 3.2 2 0 0 2 2 2 0 Zinc-finger double domain Raptor_N PF14538.1 CCF42922.1 - 0.021 14.6 0.1 0.063 13.1 0.0 1.8 2 0 0 2 2 2 0 Raptor N-terminal CASPase like domain Pneumo_att_G PF05539.6 CCF42922.1 - 0.021 14.2 7.9 0.034 13.5 5.5 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G zf-C2H2 PF00096.21 CCF42922.1 - 0.042 14.2 21.0 0.4 11.1 0.5 4.5 4 1 0 4 4 4 0 Zinc finger, C2H2 type zf-TRAF PF02176.13 CCF42922.1 - 0.58 10.5 4.6 0.15 12.4 0.4 2.2 2 0 0 2 2 2 0 TRAF-type zinc finger zf-H2C2_5 PF13909.1 CCF42922.1 - 9.4 6.6 9.4 74 3.8 0.2 4.0 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Glyco_hydro_43 PF04616.9 CCF42923.1 - 1.3e-18 67.1 1.3 2.1e-18 66.4 0.9 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_31 PF01055.21 CCF42924.1 - 1.7e-170 567.6 1.6 2.1e-170 567.3 1.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 CCF42924.1 - 3.7e-12 45.9 2.6 1.8e-11 43.7 1.0 2.7 3 0 0 3 3 3 1 Galactose mutarotase-like Glyco_hydro_28 PF00295.12 CCF42925.1 - 5e-49 167.0 11.8 7.9e-49 166.3 8.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 adh_short PF00106.20 CCF42926.1 - 1.7e-15 57.3 4.3 4.7e-15 55.9 3.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF42926.1 - 2.3e-09 37.1 1.0 3.6e-09 36.5 0.7 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF42926.1 - 0.00017 21.0 0.0 0.00025 20.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF42926.1 - 0.044 13.7 0.7 0.1 12.6 0.5 1.7 1 1 0 1 1 1 0 NADH(P)-binding ADH_zinc_N_2 PF13602.1 CCF42928.1 - 3.9e-23 82.7 0.1 4.6e-23 82.4 0.1 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 CCF42928.1 - 3.6e-10 39.4 0.0 5.4e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FAD-oxidase_C PF02913.14 CCF42929.1 - 8.4e-18 64.5 0.1 1.1e-17 64.2 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain TauD PF02668.11 CCF42930.1 - 5.4e-32 111.4 0.2 7e-32 111.0 0.2 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family HsbA PF12296.3 CCF42931.1 - 5.5e-14 52.0 1.0 5.5e-14 52.0 0.7 1.8 2 0 0 2 2 2 1 Hydrophobic surface binding protein A ABC_tran PF00005.22 CCF42935.1 - 6.6e-32 110.6 0.0 1.3e-31 109.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 CCF42935.1 - 3.7e-09 36.3 5.4 4.7e-09 36.0 3.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 CCF42935.1 - 9.5e-07 28.2 0.0 1.6e-05 24.2 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 CCF42935.1 - 9.5e-05 22.4 0.1 0.0002 21.3 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.1 CCF42935.1 - 0.0002 21.4 0.0 0.023 14.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CCF42935.1 - 0.0023 18.0 0.0 0.021 14.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 CCF42935.1 - 0.0041 16.3 0.0 0.0085 15.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Zeta_toxin PF06414.7 CCF42935.1 - 0.015 14.4 0.0 0.032 13.3 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin DUF87 PF01935.12 CCF42935.1 - 0.017 14.9 0.0 0.04 13.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_29 PF13555.1 CCF42935.1 - 0.028 13.9 0.2 0.078 12.5 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF815 PF05673.8 CCF42935.1 - 0.039 12.8 0.0 0.071 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA PF00004.24 CCF42935.1 - 0.052 13.7 0.0 0.68 10.1 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CCF42935.1 - 0.099 13.4 0.0 0.26 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 CCF42935.1 - 0.1 12.5 0.2 0.8 9.6 0.1 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.1 CCF42935.1 - 0.11 11.8 0.4 0.85 8.9 0.3 2.2 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 CCF42935.1 - 0.13 12.1 0.0 0.31 11.0 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase POTRA_2 PF08479.6 CCF42936.1 - 0.17 11.5 2.6 1.8 8.2 0.1 3.4 3 2 1 4 4 4 0 POTRA domain, ShlB-type Ribosomal_L44 PF00935.14 CCF42937.1 - 1.1e-34 118.2 12.0 1.6e-34 117.7 8.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 Sugar_tr PF00083.19 CCF42938.1 - 1.6e-52 178.6 6.9 1.9e-52 178.4 4.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF42938.1 - 2.4e-17 62.7 9.8 2.8e-17 62.4 6.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF42938.1 - 0.00063 18.0 0.9 0.00074 17.8 0.6 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) cIII PF08134.6 CCF42938.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 cIII protein family YrhK PF14145.1 CCF42938.1 - 0.34 10.5 0.1 0.34 10.5 0.1 2.9 4 0 0 4 4 4 0 YrhK-like protein AA_permease PF00324.16 CCF42939.1 - 0.0019 16.5 0.4 0.0023 16.3 0.3 1.0 1 0 0 1 1 1 1 Amino acid permease FAD_binding_3 PF01494.14 CCF42940.1 - 1.2e-88 297.5 0.0 1.6e-88 297.1 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.7 CCF42940.1 - 5.8e-56 188.7 0.0 9.9e-56 187.9 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain HI0933_like PF03486.9 CCF42940.1 - 6.4e-05 21.5 0.2 9.8e-05 20.9 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.19 CCF42940.1 - 0.00023 20.1 0.2 0.0004 19.3 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 CCF42940.1 - 0.001 18.2 0.0 0.0023 17.0 0.0 1.5 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.1 CCF42940.1 - 0.0072 16.3 0.1 0.042 13.8 0.1 2.4 3 0 0 3 3 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF42940.1 - 0.012 15.5 0.4 0.033 14.0 0.1 1.9 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF42940.1 - 0.027 14.8 0.0 0.077 13.4 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 CCF42940.1 - 0.043 12.8 0.3 0.077 12.0 0.2 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.17 CCF42940.1 - 0.059 12.2 0.3 0.094 11.5 0.2 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A DAO PF01266.19 CCF42940.1 - 0.1 11.4 0.3 0.2 10.4 0.1 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase ERG4_ERG24 PF01222.12 CCF42941.1 - 8.9e-168 558.2 0.4 1e-167 558.0 0.3 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 CCF42941.1 - 0.00023 20.5 0.1 0.00075 18.8 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PolyA_pol PF01743.15 CCF42942.1 - 5.9e-07 29.7 0.0 9e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Poly A polymerase head domain BP28CT PF08146.7 CCF42943.1 - 1.5e-39 135.1 1.3 1.5e-39 135.1 0.9 2.8 3 0 0 3 3 3 1 BP28CT (NUC211) domain HEAT PF02985.17 CCF42943.1 - 8.2e-06 25.4 6.4 0.043 13.9 0.1 5.7 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.1 CCF42943.1 - 0.00037 20.7 10.4 0.067 13.4 1.0 4.4 4 1 1 5 5 5 3 HEAT repeats RIX1 PF08167.7 CCF42943.1 - 0.94 9.1 5.4 8.8 5.9 0.0 4.3 4 2 0 4 4 4 0 rRNA processing/ribosome biogenesis HEAT_EZ PF13513.1 CCF42943.1 - 7 7.2 14.1 10 6.7 0.5 5.5 4 2 2 6 6 6 0 HEAT-like repeat Hemerythrin PF01814.18 CCF42944.1 - 4.5e-11 43.0 1.2 6e-11 42.6 0.8 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain EF-hand_1 PF00036.27 CCF42945.1 - 2.4e-24 82.7 13.5 3.8e-08 32.0 0.2 4.8 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 CCF42945.1 - 5.8e-24 81.7 4.3 7.1e-06 25.4 0.1 5.1 4 1 1 5 5 5 4 EF-hand domain EF-hand_7 PF13499.1 CCF42945.1 - 4e-22 78.1 4.8 5e-14 52.1 0.6 3.1 1 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 CCF42945.1 - 7e-17 59.9 14.5 2.5e-05 23.3 0.0 4.6 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.1 CCF42945.1 - 3.6e-15 55.2 12.7 1.7e-05 24.3 0.9 4.1 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.2 CCF42945.1 - 3.6e-09 36.3 8.1 0.0039 16.9 0.1 4.0 1 1 2 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 CCF42945.1 - 0.0001 22.1 0.4 0.022 14.6 0.0 3.1 3 0 0 3 3 3 1 EF-hand domain SPARC_Ca_bdg PF10591.4 CCF42945.1 - 0.0012 18.8 2.2 0.45 10.5 0.1 3.0 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 CCF42945.1 - 0.003 17.2 3.4 0.32 10.7 0.0 4.0 4 0 0 4 4 4 1 EF hand EF-hand_2 PF09068.6 CCF42945.1 - 0.021 14.8 0.1 2.9 7.9 0.0 3.1 3 1 1 4 4 4 0 EF hand DUF1679 PF07914.6 CCF42945.1 - 0.022 13.3 0.5 1.7 7.1 0.1 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1679) Toprim PF01751.17 CCF42945.1 - 0.027 14.4 0.0 8.8 6.3 0.0 2.3 1 1 1 2 2 2 0 Toprim domain AMP-binding PF00501.23 CCF42946.1 - 1.5e-80 270.6 0.0 2.3e-80 270.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme CdhD PF03599.11 CCF42946.1 - 0.0028 16.2 0.0 0.0046 15.5 0.0 1.2 1 0 0 1 1 1 1 CO dehydrogenase/acetyl-CoA synthase delta subunit 5-FTHF_cyc-lig PF01812.15 CCF42947.1 - 1.1e-27 96.9 0.0 1.4e-27 96.7 0.0 1.1 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family LSM PF01423.17 CCF42948.1 - 7.2e-16 57.4 0.5 8.9e-16 57.2 0.4 1.1 1 0 0 1 1 1 1 LSM domain PhnA PF03831.9 CCF42948.1 - 0.12 11.8 0.1 0.48 9.8 0.0 1.9 2 0 0 2 2 2 0 PhnA protein ATP_bind_1 PF03029.12 CCF42950.1 - 0.0002 20.9 0.0 0.00028 20.4 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_28 PF13521.1 CCF42950.1 - 0.00025 21.0 0.8 0.00046 20.1 0.1 1.7 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 CCF42950.1 - 0.00028 20.6 0.0 0.00044 19.9 0.0 1.3 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 CCF42950.1 - 0.00043 20.3 0.0 0.0007 19.6 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.18 CCF42950.1 - 0.0044 16.9 0.0 0.0072 16.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CCF42950.1 - 0.0089 15.3 0.0 0.015 14.5 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_35 PF14516.1 CCF42950.1 - 0.011 14.4 0.0 0.014 14.0 0.0 1.1 1 0 0 1 1 1 0 AAA-like domain AAA_19 PF13245.1 CCF42950.1 - 0.013 15.1 0.1 0.027 14.2 0.1 1.5 1 0 0 1 1 1 0 Part of AAA domain KTI12 PF08433.5 CCF42950.1 - 0.02 14.1 0.0 0.028 13.6 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Miro PF08477.8 CCF42950.1 - 0.027 14.9 0.0 0.047 14.1 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein FtsK_SpoIIIE PF01580.13 CCF42950.1 - 0.031 13.7 0.0 0.042 13.3 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_17 PF13207.1 CCF42950.1 - 0.045 14.5 0.1 0.078 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain ArgK PF03308.11 CCF42950.1 - 0.059 12.1 0.0 0.079 11.7 0.0 1.1 1 0 0 1 1 1 0 ArgK protein AAA PF00004.24 CCF42950.1 - 0.059 13.5 0.1 0.091 12.9 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 CCF42950.1 - 0.071 12.5 0.0 0.098 12.0 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_22 PF13401.1 CCF42950.1 - 0.081 13.0 0.1 0.14 12.2 0.0 1.4 1 1 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.12 CCF42950.1 - 0.1 11.4 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_30 PF13604.1 CCF42950.1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain Cep57_CLD_2 PF14197.1 CCF42951.1 - 0.028 14.3 2.7 0.29 11.0 1.9 2.2 1 1 0 1 1 1 0 Centrosome localisation domain of PPC89 DUF1529 PF07485.6 CCF42951.1 - 0.1 12.3 0.1 0.23 11.2 0.0 1.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1259) Trp_DMAT PF11991.3 CCF42952.1 - 1.3e-59 202.2 0.0 1.7e-59 201.8 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Cu_amine_oxid PF01179.15 CCF42953.1 - 5.9e-161 535.8 0.0 6.8e-161 535.5 0.0 1.0 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain UPF0546 PF10639.4 CCF42953.1 - 0.15 11.8 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0546 KR PF08659.5 CCF42954.1 - 5.4e-26 91.3 0.0 1.2e-25 90.2 0.0 1.6 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 CCF42954.1 - 6.3e-18 65.2 0.0 1.4e-17 64.1 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase PP-binding PF00550.20 CCF42954.1 - 1.9e-08 34.4 0.1 3.8e-08 33.4 0.1 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site TAP_C PF03943.8 CCF42956.1 - 9.1e-15 53.8 0.2 1.7e-14 52.9 0.1 1.5 1 0 0 1 1 1 1 TAP C-terminal domain LRR_4 PF12799.2 CCF42956.1 - 3.5e-09 36.0 1.5 0.00017 21.1 0.0 3.0 2 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CCF42956.1 - 6.7e-07 28.9 1.0 6.6e-05 22.5 0.1 2.4 1 1 1 2 2 2 2 Leucine rich repeat NTF2 PF02136.15 CCF42956.1 - 1.6e-05 25.2 0.0 6.4e-05 23.3 0.0 2.1 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain LRR_1 PF00560.28 CCF42956.1 - 0.001 18.7 1.0 2.8 8.2 0.0 3.6 2 1 1 3 3 3 2 Leucine Rich Repeat LRR_6 PF13516.1 CCF42956.1 - 0.0087 16.0 1.0 1.9 8.7 0.0 3.6 3 0 0 3 3 3 1 Leucine Rich repeat LRR_7 PF13504.1 CCF42956.1 - 0.012 15.7 0.1 1.4 9.3 0.0 3.5 3 0 0 3 3 3 0 Leucine rich repeat HsbA PF12296.3 CCF42957.1 - 7.4e-16 58.1 9.5 9e-16 57.8 4.9 1.9 2 0 0 2 2 2 1 Hydrophobic surface binding protein A Colicin PF01024.14 CCF42957.1 - 0.064 12.8 1.1 0.13 11.8 0.0 1.9 2 1 0 2 2 2 0 Colicin pore forming domain NRDE PF05742.7 CCF42959.1 - 6.2e-43 147.0 0.0 1.2e-42 146.1 0.0 1.3 1 1 0 1 1 1 1 NRDE protein ABC_tran PF00005.22 CCF42960.1 - 4.7e-40 137.0 0.0 3.9e-19 69.3 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 CCF42960.1 - 6.9e-19 68.3 47.0 1.5e-17 63.9 13.4 3.1 3 0 0 3 3 3 2 ABC transporter transmembrane region AAA_21 PF13304.1 CCF42960.1 - 1.8e-12 47.8 0.0 0.015 15.2 0.0 4.3 2 2 0 3 3 3 3 AAA domain SMC_N PF02463.14 CCF42960.1 - 5.6e-09 35.5 0.5 0.0027 16.9 0.0 4.3 3 1 0 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 CCF42960.1 - 3e-07 29.8 0.2 0.024 14.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 CCF42960.1 - 1.2e-05 25.4 0.0 0.033 14.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 CCF42960.1 - 1.7e-05 24.9 0.7 0.15 12.0 0.2 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.1 CCF42960.1 - 3.3e-05 23.3 0.2 0.18 11.2 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_17 PF13207.1 CCF42960.1 - 6e-05 23.8 0.0 0.17 12.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 CCF42960.1 - 0.00013 21.8 0.0 0.13 12.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 CCF42960.1 - 0.00026 20.2 0.1 0.33 10.1 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 T2SE PF00437.15 CCF42960.1 - 0.00032 19.6 0.1 0.017 14.0 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein MMR_HSR1 PF01926.18 CCF42960.1 - 0.0011 18.9 0.5 1.8 8.5 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase MobB PF03205.9 CCF42960.1 - 0.0013 18.4 0.0 0.6 9.8 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 CCF42960.1 - 0.0013 19.0 0.0 0.72 10.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.1 CCF42960.1 - 0.0017 18.7 0.1 1.6 9.0 0.0 2.3 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.18 CCF42960.1 - 0.0029 17.4 0.3 0.41 10.4 0.0 2.4 2 0 0 2 2 2 1 Dynamin family Miro PF08477.8 CCF42960.1 - 0.0067 16.9 0.0 0.38 11.2 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein AAA PF00004.24 CCF42960.1 - 0.0081 16.3 0.0 8.4 6.5 0.0 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF4644 PF15486.1 CCF42960.1 - 0.015 15.2 0.2 0.031 14.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4644) Zeta_toxin PF06414.7 CCF42960.1 - 0.035 13.2 0.0 7.5 5.5 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_10 PF12846.2 CCF42960.1 - 0.049 13.0 1.8 2.8 7.2 0.0 2.6 3 0 0 3 3 2 0 AAA-like domain FtsK_SpoIIIE PF01580.13 CCF42960.1 - 0.09 12.2 0.1 5.5 6.4 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family PduV-EutP PF10662.4 CCF42960.1 - 0.1 12.0 0.4 3.1 7.2 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF815 PF05673.8 CCF42960.1 - 0.11 11.4 0.1 6.2 5.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ABC_ATPase PF09818.4 CCF42960.1 - 0.31 9.5 1.1 1.7 7.1 0.0 2.5 3 0 0 3 3 3 0 Predicted ATPase of the ABC class Dus PF01207.12 CCF42966.1 - 1.3e-53 181.8 0.0 2.2e-53 181.1 0.0 1.3 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Dynamin_N PF00350.18 CCF42967.1 - 4.2e-17 62.4 0.1 1.1e-16 61.1 0.0 1.8 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.18 CCF42967.1 - 1.1e-09 38.2 0.0 7e-09 35.6 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CCF42967.1 - 5.1e-07 29.3 0.4 5.3e-06 25.9 0.3 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_18 PF13238.1 CCF42967.1 - 0.0049 17.1 0.0 0.016 15.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain IIGP PF05049.8 CCF42967.1 - 0.02 13.7 0.0 0.039 12.7 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_29 PF13555.1 CCF42967.1 - 0.029 13.9 0.1 0.12 11.8 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain Miro PF08477.8 CCF42967.1 - 0.061 13.8 0.1 0.66 10.4 0.1 2.5 1 1 0 1 1 1 0 Miro-like protein DUF3210 PF11489.3 CCF42968.1 - 4.7e-96 323.1 20.6 4.7e-96 323.1 14.3 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3210) Ras PF00071.17 CCF42970.1 - 5.7e-54 181.8 0.0 6.6e-54 181.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF42970.1 - 7.6e-18 65.1 0.0 1.1e-17 64.6 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CCF42970.1 - 6.8e-07 28.6 0.0 8.9e-07 28.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Aldedh PF00171.17 CCF42971.1 - 6.8e-82 275.2 0.2 7.7e-82 275.0 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family GTP_cyclohydro2 PF00925.15 CCF42971.1 - 0.13 11.5 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 GTP cyclohydrolase II WSC PF01822.14 CCF42972.1 - 4.9e-32 109.7 30.9 4.4e-19 68.2 6.2 5.4 4 1 2 6 6 6 2 WSC domain KAR9 PF08580.5 CCF42972.1 - 2.7 6.1 7.4 3.6 5.7 5.1 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 DUF605 PF04652.11 CCF42972.1 - 9 5.5 15.4 0.57 9.5 5.9 1.9 2 0 0 2 2 2 0 Vta1 like KR PF08659.5 CCF42973.1 - 1.7e-52 177.7 0.0 2.4e-52 177.2 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 CCF42973.1 - 7.4e-43 146.3 0.0 1.2e-42 145.6 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase PP-binding PF00550.20 CCF42973.1 - 6.8e-08 32.6 0.2 1.3e-07 31.8 0.1 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site Shikimate_DH PF01488.15 CCF42973.1 - 0.098 12.7 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase EamA PF00892.15 CCF42974.1 - 5.5e-15 55.5 31.4 1.3e-09 38.1 5.7 2.4 2 0 0 2 2 2 2 EamA-like transporter family PTPLA PF04387.9 CCF42974.1 - 0.16 11.4 4.5 0.21 10.9 2.6 1.6 1 1 0 1 1 1 0 Protein tyrosine phosphatase-like protein, PTPLA p450 PF00067.17 CCF42975.1 - 1.7e-31 109.2 0.0 2.1e-31 108.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_A8 PF01252.13 CCF42976.1 - 0.025 14.2 0.0 0.041 13.4 0.0 1.3 1 0 0 1 1 1 0 Signal peptidase (SPase) II Herpes_UL51 PF04540.8 CCF42976.1 - 0.12 11.9 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL51 protein Het-C PF07217.6 CCF42977.1 - 2e-153 511.8 0.0 2.3e-153 511.5 0.0 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C DUF605 PF04652.11 CCF42977.1 - 2.5 7.4 9.4 4 6.7 6.5 1.3 1 0 0 1 1 1 0 Vta1 like PP2C PF00481.16 CCF42978.1 - 6.9e-17 61.6 0.0 9.8e-17 61.1 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 CCF42978.1 - 0.012 15.3 0.0 0.015 15.0 0.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 CCF42978.1 - 0.023 14.1 0.0 0.03 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein phosphatase 2C Acyl_transf_1 PF00698.16 CCF42979.1 - 1.1e-47 163.0 6.8 2.8e-39 135.3 4.9 2.7 2 1 0 2 2 2 2 Acyl transferase domain Ketoacyl-synt_C PF02801.17 CCF42979.1 - 2.6e-34 117.6 0.7 5.8e-34 116.4 0.2 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.21 CCF42979.1 - 1.9e-13 50.5 2.1 6e-13 48.8 0.2 2.4 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Med11 PF10280.4 CCF42981.1 - 1e-30 106.1 0.0 1.4e-30 105.7 0.0 1.1 1 0 0 1 1 1 1 Mediator complex protein UBA PF00627.26 CCF42982.1 - 0.00027 20.6 0.0 0.00048 19.8 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain adh_short_C2 PF13561.1 CCF42984.1 - 3.1e-16 59.8 0.0 4e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF42984.1 - 7.7e-09 35.6 0.0 1e-08 35.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Zn_clus PF00172.13 CCF42985.1 - 2.2e-07 30.6 6.1 3.4e-07 30.0 4.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UDPGP PF01704.13 CCF42986.1 - 9.1e-186 617.4 0.7 1e-185 617.2 0.5 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DUF4301 PF14134.1 CCF42986.1 - 0.05 12.1 0.3 0.74 8.2 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4301) DUF3605 PF12239.3 CCF42987.1 - 2.8e-56 189.7 0.3 3.3e-56 189.5 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) FolB PF02152.13 CCF42988.1 - 7e-20 71.2 0.0 2.5e-15 56.5 0.0 2.2 2 0 0 2 2 2 2 Dihydroneopterin aldolase Peptidase_M1 PF01433.15 CCF42989.1 - 8.5e-140 466.2 0.0 1.6e-139 465.3 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M1 ERAP1_C PF11838.3 CCF42989.1 - 7e-82 275.2 1.7 1.2e-81 274.5 1.1 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 CCF42989.1 - 4.1e-19 68.8 0.2 7.9e-19 67.9 0.1 1.4 1 0 0 1 1 1 1 Peptidase MA superfamily Enolase_N PF03952.11 CCF42990.1 - 2.5e-48 163.3 0.3 2.8e-48 163.1 0.2 1.0 1 0 0 1 1 1 1 Enolase, N-terminal domain MFS_1 PF07690.11 CCF42992.1 - 3.2e-26 91.8 22.6 6.8e-25 87.5 13.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Amidase PF01425.16 CCF42993.1 - 1.4e-89 300.9 0.0 1.7e-89 300.6 0.0 1.1 1 0 0 1 1 1 1 Amidase Amino_oxidase PF01593.19 CCF42994.1 - 6.3e-48 163.9 0.2 4.5e-47 161.1 0.2 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Ribonuc_L-PSP PF01042.16 CCF42994.1 - 1.2e-16 60.5 0.3 2.4e-16 59.6 0.1 1.6 2 0 0 2 2 2 1 Endoribonuclease L-PSP NAD_binding_8 PF13450.1 CCF42994.1 - 1.8e-13 50.3 0.2 5.3e-13 48.7 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CCF42994.1 - 7.7e-09 34.8 0.5 1.4e-08 34.0 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.1 CCF42994.1 - 9.5e-07 29.0 0.4 7.5e-05 22.8 0.2 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF42994.1 - 1.8e-06 27.0 0.1 1.8e-06 27.0 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.12 CCF42994.1 - 3.4e-06 26.3 0.0 5.9e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.7 CCF42994.1 - 3.7e-06 26.1 0.1 2.2e-05 23.5 0.2 1.9 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_oxidored PF12831.2 CCF42994.1 - 3.7e-05 22.9 0.2 5.7e-05 22.3 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF42994.1 - 3.8e-05 23.6 0.0 6.2e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 CCF42994.1 - 0.00013 21.1 0.8 0.00019 20.5 0.5 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 CCF42994.1 - 0.00046 18.7 0.9 0.00068 18.2 0.3 1.5 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.17 CCF42994.1 - 0.0014 17.5 0.7 0.0024 16.7 0.5 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.16 CCF42994.1 - 0.0051 16.3 0.1 0.024 14.2 0.1 1.9 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.22 CCF42994.1 - 0.04 14.3 0.1 0.082 13.3 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Aldolase_II PF00596.16 CCF42995.1 - 7.4e-48 162.5 0.1 9.4e-48 162.2 0.1 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain DUF3148 PF11347.3 CCF42995.1 - 0.075 12.6 0.0 0.32 10.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3148) Hce2 PF14856.1 CCF42996.1 - 1.8e-13 50.2 0.1 2.3e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor HET PF06985.6 CCF42997.1 - 3.6e-23 82.2 0.0 6.3e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Pkinase PF00069.20 CCF42997.1 - 1e-05 24.8 0.0 1.7e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Arginase PF00491.16 CCF42998.1 - 1e-79 267.7 0.7 1.2e-79 267.5 0.5 1.0 1 0 0 1 1 1 1 Arginase family Phytoreo_P8 PF07124.6 CCF42999.1 - 0.13 10.8 0.0 0.19 10.3 0.0 1.2 1 0 0 1 1 1 0 Phytoreovirus outer capsid protein P8 SnoaL_2 PF12680.2 CCF43000.1 - 0.00023 21.5 0.0 0.00032 21.0 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF2358 PF10184.4 CCF43000.1 - 0.00058 19.7 0.0 0.00087 19.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) TonB_2 PF13103.1 CCF43000.1 - 0.097 12.7 0.1 0.19 11.7 0.1 1.5 1 0 0 1 1 1 0 TonB C terminal Glyco_hydro_20 PF00728.17 CCF43002.1 - 0.097 11.8 0.4 0.16 11.0 0.1 1.4 1 1 0 1 1 1 0 Glycosyl hydrolase family 20, catalytic domain HypA PF01155.14 CCF43002.1 - 2.9 7.6 5.7 0.65 9.6 1.6 1.7 1 1 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Oxidored_FMN PF00724.15 CCF43004.1 - 9.8e-69 231.9 0.0 1.3e-68 231.5 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.12 CCF43004.1 - 0.0023 16.7 0.3 0.0093 14.8 0.0 1.9 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) XH PF03469.9 CCF43004.1 - 0.18 11.4 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 XH domain Fungal_trans_2 PF11951.3 CCF43005.1 - 0.00029 19.5 3.5 0.0041 15.7 2.4 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain bZIP_1 PF00170.16 CCF43006.1 - 7.1e-12 45.0 7.3 8.8e-12 44.8 5.1 1.1 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 CCF43006.1 - 4.9e-07 29.4 10.3 6.9e-07 28.9 7.1 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 CCF43006.1 - 9.6e-05 22.6 6.3 0.00013 22.2 4.3 1.1 1 0 0 1 1 1 1 bZIP Maf transcription factor TMF_DNA_bd PF12329.3 CCF43006.1 - 0.042 13.6 2.9 0.057 13.2 1.7 1.4 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Adaptin_binding PF10199.4 CCF43006.1 - 0.05 13.8 0.5 0.058 13.6 0.3 1.1 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Takusan PF04822.8 CCF43006.1 - 0.06 13.1 2.9 0.091 12.5 2.0 1.3 1 0 0 1 1 1 0 Takusan IncA PF04156.9 CCF43006.1 - 0.083 12.4 0.2 0.091 12.3 0.1 1.1 1 0 0 1 1 1 0 IncA protein DUF1985 PF09331.6 CCF43006.1 - 0.098 12.4 0.2 0.13 12.1 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1985) DUF4463 PF14703.1 CCF43006.1 - 0.3 11.6 2.6 0.23 11.9 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4463) DUF4140 PF13600.1 CCF43006.1 - 0.39 11.1 2.8 0.5 10.8 1.9 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Aldedh PF00171.17 CCF43009.1 - 1.1e-136 455.8 0.0 1.4e-136 455.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 CCF43009.1 - 2.1e-05 23.4 0.1 6.2e-05 21.8 0.1 1.6 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF2890 PF11081.3 CCF43010.1 - 0.13 12.2 6.2 0.17 11.9 4.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) DUF1510 PF07423.6 CCF43010.1 - 3.5 6.9 11.4 4 6.7 7.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Nop14 PF04147.7 CCF43010.1 - 4.2 5.1 20.8 4.6 5.0 14.4 1.0 1 0 0 1 1 1 0 Nop14-like family DTHCT PF08070.6 CCF43010.1 - 8.4 7.1 12.9 52 4.5 8.8 2.0 1 1 1 2 2 2 0 DTHCT (NUC029) region Spc97_Spc98 PF04130.8 CCF43013.1 - 4.1e-23 81.5 0.0 5.1e-23 81.2 0.0 1.2 1 0 0 1 1 1 1 Spc97 / Spc98 family TDH PF03347.8 CCF43014.1 - 0.15 11.5 0.1 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Vibrio thermostable direct hemolysin Cript PF10235.4 CCF43016.1 - 0.017 15.4 0.4 0.029 14.7 0.3 1.4 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT DUF4215 PF13948.1 CCF43016.1 - 0.19 12.0 6.1 0.31 11.2 4.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4215) EGF PF00008.22 CCF43016.1 - 0.2 11.6 7.0 0.14 12.1 3.4 1.9 1 1 0 1 1 1 0 EGF-like domain DUF2667 PF10868.3 CCF43016.1 - 0.77 10.1 5.5 23 5.4 3.8 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2667) FXa_inhibition PF14670.1 CCF43016.1 - 0.96 9.6 7.1 2.1 8.5 4.9 1.7 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site DUF500 PF04366.7 CCF43018.1 - 7.8e-45 151.3 0.1 1.3e-44 150.6 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF500) Glyco_transf_28 PF03033.15 CCF43019.1 - 3.7e-21 75.3 0.0 9.5e-21 74.0 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Metallothio_Cad PF07846.6 CCF43021.1 - 0.0099 15.7 0.7 7.7 6.5 0.0 3.0 3 0 0 3 3 3 2 Metallothionein family DDE_1 PF03184.14 CCF43022.1 - 3.5e-14 52.4 0.0 6e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 CCF43022.1 - 2.2e-13 49.8 0.1 8.7e-13 47.8 0.0 2.1 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF43022.1 - 8e-12 44.5 0.1 1.5e-11 43.6 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.1 CCF43022.1 - 0.0011 18.5 0.3 0.0038 16.8 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 CCF43022.1 - 0.0012 18.8 0.2 0.0041 17.0 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain CENP-B_N PF04218.8 CCF43022.1 - 0.021 14.2 0.0 0.038 13.3 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_29 PF13551.1 CCF43022.1 - 0.28 11.3 2.0 0.34 11.0 0.4 2.0 2 1 0 2 2 2 0 Winged helix-turn helix TIM PF00121.13 CCF43023.1 - 1.1e-59 201.5 0.0 1.2e-59 201.3 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase LacAB_rpiB PF02502.13 CCF43024.1 - 7.6e-40 135.7 0.3 8.7e-40 135.6 0.2 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase Dak1 PF02733.12 CCF43025.1 - 1.3e-108 362.4 0.0 1.7e-108 362.0 0.0 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.12 CCF43025.1 - 1.7e-41 141.7 0.2 2.7e-41 141.1 0.2 1.3 1 0 0 1 1 1 1 DAK2 domain Fungal_trans PF04082.13 CCF43026.1 - 1.5e-25 89.6 0.1 3e-25 88.6 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF43026.1 - 0.00042 20.1 10.7 0.00086 19.1 7.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CKS PF01111.14 CCF43027.1 - 4.9e-36 122.4 0.8 6.4e-36 122.0 0.6 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Indigoidine_A PF04227.7 CCF43028.1 - 5.9e-101 337.5 1.7 7.8e-101 337.1 1.2 1.2 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.19 CCF43028.1 - 0.00036 19.7 0.0 0.00081 18.6 0.0 1.6 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Sugar_tr PF00083.19 CCF43029.1 - 9.5e-48 162.8 14.0 1.4e-47 162.3 9.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF43029.1 - 1e-23 83.6 21.6 1.9e-23 82.7 15.0 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily HET PF06985.6 CCF43030.1 - 5.5e-19 68.7 0.0 8.9e-19 68.0 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Hid1 PF12722.2 CCF43031.1 - 4.1e-26 90.9 0.4 7.4e-25 86.8 0.3 2.0 1 1 0 1 1 1 1 High-temperature-induced dauer-formation protein His_Phos_2 PF00328.17 CCF43033.1 - 2.5e-35 122.4 0.1 3.6e-35 121.9 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Ribosomal_L19e PF01280.15 CCF43033.1 - 0.19 11.4 2.8 2.9 7.6 0.3 2.5 2 1 1 3 3 3 0 Ribosomal protein L19e Myb_DNA-bind_6 PF13921.1 CCF43036.1 - 5e-05 23.3 0.9 0.00011 22.2 0.6 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF688 PF05097.7 CCF43036.1 - 0.012 14.6 0.1 0.015 14.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF688) Myb_DNA-binding PF00249.26 CCF43036.1 - 0.014 15.4 1.2 0.036 14.1 0.8 1.8 1 1 0 1 1 1 0 Myb-like DNA-binding domain Cut8_N PF14482.1 CCF43036.1 - 3.3 7.7 8.1 3.2 7.8 3.5 2.5 1 1 0 1 1 1 0 Cut8 proteasome-binding domain zf-B_box PF00643.19 CCF43038.1 - 0.0099 15.7 4.8 0.021 14.7 3.3 1.6 1 0 0 1 1 1 1 B-box zinc finger DAO PF01266.19 CCF43039.1 - 3e-21 75.7 0.1 3.8e-21 75.4 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase APH PF01636.18 CCF43042.1 - 1.8e-17 63.8 0.4 2.7e-17 63.2 0.2 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CCF43042.1 - 0.025 14.1 0.0 0.038 13.5 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Condensation PF00668.15 CCF43044.1 - 6.3e-55 186.1 0.0 1.7e-31 109.1 0.0 2.7 2 1 0 2 2 2 2 Condensation domain Cyclin_N PF00134.18 CCF43045.1 - 3.9e-11 42.6 0.1 7.2e-11 41.7 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain TFIIB PF00382.14 CCF43045.1 - 0.076 12.8 0.1 0.076 12.8 0.1 1.7 2 0 0 2 2 2 0 Transcription factor TFIIB repeat ACC_epsilon PF13822.1 CCF43045.1 - 9 6.7 9.2 0.48 10.8 2.2 2.1 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit DDT PF02791.12 CCF43046.1 - 2.8e-18 65.4 0.4 5.3e-18 64.5 0.3 1.5 1 0 0 1 1 1 1 DDT domain WHIM2 PF15613.1 CCF43046.1 - 9.6e-14 50.6 0.3 1.8e-13 49.8 0.2 1.5 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 2 Sigma70_ner PF04546.8 CCF43046.1 - 0.0087 15.6 3.1 0.0087 15.6 2.1 3.8 3 1 0 4 4 4 2 Sigma-70, non-essential region WHIM1 PF15612.1 CCF43046.1 - 0.016 15.1 1.3 0.063 13.2 0.1 2.5 2 0 0 2 2 2 0 WSTF, HB1, Itc1p, MBD9 motif 1 WHIM3 PF15614.1 CCF43046.1 - 0.029 14.1 0.6 0.098 12.4 0.1 2.1 2 0 0 2 2 2 0 WSTF, HB1, Itc1p, MBD9 motif 3 GldM_N PF12081.3 CCF43046.1 - 6.7 6.1 12.6 0.96 8.9 0.6 2.9 3 0 0 3 3 3 0 GldM N-terminal domain Nop53 PF07767.6 CCF43046.1 - 8 5.3 55.1 0.13 11.2 13.7 3.5 3 1 0 3 3 3 0 Nop53 (60S ribosomal biogenesis) CDC45 PF02724.9 CCF43046.1 - 8.5 4.2 32.8 0.54 8.2 1.3 3.1 3 0 0 3 3 3 0 CDC45-like protein ABC_tran PF00005.22 CCF43047.1 - 1.5e-17 64.1 0.0 3.8e-17 62.8 0.0 1.7 1 1 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 CCF43047.1 - 4.1e-11 42.7 0.4 6.7e-11 42.1 0.3 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_25 PF13481.1 CCF43047.1 - 8.1e-05 22.1 0.0 0.00014 21.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF43047.1 - 0.00031 20.7 0.2 0.0014 18.6 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.1 CCF43047.1 - 0.013 15.2 0.0 0.061 13.0 0.0 2.2 1 0 0 1 1 1 0 Part of AAA domain AAA_14 PF13173.1 CCF43047.1 - 0.015 15.2 0.0 0.026 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.14 CCF43047.1 - 0.016 14.4 0.0 2.7 7.1 0.0 2.1 1 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain Viral_helicase1 PF01443.13 CCF43047.1 - 0.02 14.3 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.1 CCF43047.1 - 0.031 13.7 0.8 0.068 12.7 0.2 1.8 2 0 0 2 2 1 0 P-loop containing region of AAA domain AAA_23 PF13476.1 CCF43047.1 - 0.038 14.3 0.1 0.061 13.6 0.1 1.2 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 CCF43047.1 - 0.045 13.1 0.0 0.096 12.1 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_10 PF12846.2 CCF43047.1 - 0.058 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain ATP-synt_ab PF00006.20 CCF43047.1 - 0.065 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_28 PF13521.1 CCF43047.1 - 0.075 12.9 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.1 CCF43047.1 - 0.1 12.5 0.0 16 5.3 0.0 2.1 1 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 CCF43047.1 - 0.18 11.9 0.0 0.54 10.4 0.0 1.8 2 0 0 2 2 1 0 RNA helicase AAA_18 PF13238.1 CCF43047.1 - 0.18 12.0 0.0 0.33 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 CCF43047.1 - 0.31 10.6 0.0 0.52 9.9 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase Alpha-amylase PF00128.19 CCF43048.1 - 5e-15 55.7 0.0 6.2e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF676 PF05057.9 CCF43049.1 - 8.3e-43 146.2 0.0 2.2e-27 95.8 0.0 3.2 3 0 0 3 3 3 3 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.2 CCF43049.1 - 0.006 16.3 0.0 0.015 15.0 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.20 CCF43049.1 - 0.0092 15.6 0.0 0.023 14.3 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.8 CCF43049.1 - 0.035 13.6 0.0 0.091 12.3 0.0 1.6 2 0 0 2 2 2 0 PGAP1-like protein DDE_1 PF03184.14 CCF43051.1 - 2.4e-53 180.4 0.0 3.4e-53 179.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.11 CCF43051.1 - 4.7e-12 45.2 5.0 1.5e-11 43.6 0.0 3.0 3 0 0 3 3 3 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF43051.1 - 3.4e-07 29.9 0.0 9.8e-07 28.4 0.0 1.9 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain peroxidase PF00141.18 CCF43052.1 - 3.1e-50 170.8 0.0 4.9e-50 170.1 0.0 1.3 1 0 0 1 1 1 1 Peroxidase ATP11 PF06644.6 CCF43053.1 - 3.3e-87 292.3 0.0 3.8e-87 292.1 0.0 1.0 1 0 0 1 1 1 1 ATP11 protein Sel1 PF08238.7 CCF43054.1 - 5.3e-37 125.4 30.7 4.8e-05 23.8 0.1 7.5 7 0 0 7 7 7 7 Sel1 repeat Glyoxalase_2 PF12681.2 CCF43055.1 - 1.3e-06 28.9 1.6 6e-05 23.6 0.1 2.3 2 0 0 2 2 2 1 Glyoxalase-like domain Glyoxalase PF00903.20 CCF43055.1 - 3.6e-06 26.9 6.7 0.0012 18.8 1.6 2.7 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TPR_3 PF07720.7 CCF43055.1 - 0.11 12.2 2.2 0.69 9.7 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 CCF43055.1 - 0.14 12.1 0.1 2.4 8.2 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat GATA PF00320.22 CCF43056.1 - 2.7e-05 23.4 5.6 0.0039 16.5 1.0 2.5 2 0 0 2 2 2 2 GATA zinc finger Metallophos PF00149.23 CCF43057.1 - 8.3e-08 31.8 1.4 1.7e-07 30.8 0.9 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Pyr_redox_2 PF07992.9 CCF43062.1 - 9.8e-39 133.3 0.3 1.7e-38 132.5 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 CCF43062.1 - 3.2e-34 117.2 0.4 7.6e-34 116.0 0.2 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 CCF43062.1 - 2e-19 69.7 0.5 5.4e-18 65.1 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF43062.1 - 1.6e-09 38.1 0.0 1.5e-08 34.9 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF43062.1 - 3.1e-05 23.0 0.0 0.0026 16.7 0.0 2.1 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.9 CCF43062.1 - 0.00059 18.4 1.6 2.5 6.4 0.4 3.3 3 1 0 3 3 3 3 HI0933-like protein FAD_oxidored PF12831.2 CCF43062.1 - 0.012 14.6 0.1 0.028 13.5 0.0 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.17 CCF43062.1 - 0.032 13.0 0.4 0.066 12.0 0.1 1.8 3 0 0 3 3 3 0 Glucose inhibited division protein A FAD_binding_2 PF00890.19 CCF43062.1 - 0.13 11.0 3.4 1.3 7.8 1.2 2.2 2 0 0 2 2 2 0 FAD binding domain NAD_binding_8 PF13450.1 CCF43062.1 - 0.15 12.1 1.5 0.48 10.4 1.0 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 CCF43062.1 - 0.46 9.5 2.3 0.39 9.7 0.3 1.7 2 0 0 2 2 2 0 Thi4 family ADH_zinc_N PF00107.21 CCF43064.1 - 4.3e-21 74.8 0.0 7.2e-21 74.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF43064.1 - 4.4e-06 27.5 0.0 9.2e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase E1-E2_ATPase PF00122.15 CCF43067.1 - 4.4e-17 61.8 0.0 6.1e-17 61.4 0.0 1.2 1 0 0 1 1 1 1 E1-E2 ATPase Erv26 PF04148.8 CCF43067.1 - 0.0054 16.1 0.3 0.44 9.8 0.0 2.3 2 0 0 2 2 2 2 Transmembrane adaptor Erv26 Cutinase PF01083.17 CCF43068.1 - 6.6e-48 162.7 0.1 8.3e-48 162.4 0.1 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.6 CCF43068.1 - 0.0077 15.6 0.0 0.02 14.3 0.0 1.7 2 0 0 2 2 2 1 PE-PPE domain VirJ PF06057.6 CCF43068.1 - 0.021 14.6 0.0 0.034 13.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) VPS9 PF02204.13 CCF43069.1 - 2e-29 101.6 0.1 4.1e-29 100.6 0.1 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain CUE PF02845.11 CCF43069.1 - 1.3e-08 34.1 0.1 1.4e-07 30.8 0.0 2.3 2 0 0 2 2 2 1 CUE domain NdhL PF10716.4 CCF43070.1 - 0.00044 19.9 0.7 0.00044 19.9 0.5 2.1 2 0 0 2 2 2 2 NADH dehydrogenase transmembrane subunit DUF412 PF04217.8 CCF43070.1 - 0.048 13.4 0.3 0.085 12.6 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF412 UPF0697 PF15117.1 CCF43070.1 - 0.064 13.0 0.4 0.12 12.1 0.3 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0697 Acyl_transf_3 PF01757.17 CCF43071.1 - 3.3e-31 108.3 33.6 1.9e-30 105.8 23.3 2.2 1 1 0 1 1 1 1 Acyltransferase family DUF1600 PF07667.6 CCF43071.1 - 0.25 11.4 3.4 0.59 10.2 0.1 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1600) Abhydrolase_6 PF12697.2 CCF43072.1 - 2.4e-32 112.6 0.0 3e-32 112.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF43072.1 - 2.2e-20 73.1 0.1 5.2e-17 62.1 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF43072.1 - 7.7e-13 48.4 0.0 2e-12 47.0 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.9 CCF43072.1 - 3.3e-05 22.5 0.0 5.2e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Ndr family Hydrolase_4 PF12146.3 CCF43072.1 - 3.4e-05 23.5 0.0 6.3e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Putative lysophospholipase Peptidase_S9 PF00326.16 CCF43072.1 - 0.068 12.3 0.2 9.2 5.4 0.1 2.7 2 1 0 2 2 2 0 Prolyl oligopeptidase family Clr5 PF14420.1 CCF43073.1 - 1.3e-17 63.4 0.3 2.3e-17 62.6 0.2 1.4 1 0 0 1 1 1 1 Clr5 domain TilS PF09179.6 CCF43073.1 - 0.063 13.3 0.1 0.099 12.6 0.0 1.3 1 0 0 1 1 1 0 TilS substrate binding domain Cnl2_NKP2 PF09447.5 CCF43073.1 - 0.079 12.6 0.2 0.11 12.1 0.1 1.4 1 1 0 1 1 1 0 Cnl2/NKP2 family protein WD40 PF00400.27 CCF43074.1 - 1.4e-77 253.0 14.9 1.4e-12 46.9 0.3 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 CCF43074.1 - 4.1e-10 38.4 6.7 0.00068 17.9 0.1 5.1 2 2 4 6 6 6 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 CCF43074.1 - 5e-05 22.2 0.0 0.092 11.4 0.0 3.2 2 1 1 3 3 3 3 Nup133 N terminal like CCDC155 PF14662.1 CCF43076.1 - 0.0031 17.1 7.4 0.0041 16.7 5.1 1.1 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 DUF2228 PF10228.4 CCF43076.1 - 0.022 14.3 0.1 0.029 13.9 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) ATP-synt_D PF01813.12 CCF43076.1 - 0.042 13.3 0.5 0.042 13.3 0.4 1.8 1 1 1 2 2 2 0 ATP synthase subunit D APG6 PF04111.7 CCF43076.1 - 0.063 12.3 4.4 0.075 12.0 3.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 GidB PF02527.10 CCF43076.1 - 0.065 12.3 0.5 0.083 12.0 0.4 1.1 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G V_ATPase_I PF01496.14 CCF43076.1 - 0.39 8.5 1.3 0.44 8.3 0.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4446 PF14584.1 CCF43076.1 - 1.4 8.7 4.9 1.4 8.7 0.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DDE_1 PF03184.14 CCF43077.1 - 8e-26 90.5 0.0 1.3e-25 89.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.11 CCF43077.1 - 3.2e-13 49.0 0.0 7e-13 47.8 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF43077.1 - 7.1e-10 38.5 0.0 1.7e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.1 CCF43077.1 - 0.0094 15.5 0.1 0.066 12.8 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 CCF43077.1 - 0.028 14.4 0.1 0.17 11.9 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain bZIP_1 PF00170.16 CCF43078.1 - 0.28 11.1 3.1 0.55 10.2 2.2 1.5 1 0 0 1 1 1 0 bZIP transcription factor Pyr_redox_3 PF13738.1 CCF43080.1 - 5.4e-28 98.4 0.0 9.2e-28 97.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 CCF43080.1 - 1.3e-12 46.6 0.0 2.5e-12 45.8 0.0 1.5 1 1 1 2 2 2 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.1 CCF43080.1 - 3.7e-10 39.2 0.0 8.6e-10 38.0 0.0 1.6 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 CCF43080.1 - 4e-10 39.9 0.0 8.1e-10 38.9 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF43080.1 - 4.9e-05 23.6 0.0 2.5 8.5 0.0 3.3 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 CCF43080.1 - 6.4e-05 22.1 0.2 0.0005 19.2 0.2 2.1 1 1 1 2 2 2 1 FAD binding domain Shikimate_DH PF01488.15 CCF43080.1 - 0.00014 22.0 0.0 0.013 15.6 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 CCF43080.1 - 0.00018 20.7 0.1 0.0043 16.2 0.0 2.1 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_2 PF00890.19 CCF43080.1 - 0.0025 16.7 0.0 0.64 8.7 0.1 2.3 2 0 0 2 2 2 2 FAD binding domain CPSase_L_chain PF00289.17 CCF43080.1 - 0.0025 17.8 0.0 2.2 8.4 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, N-terminal domain GIDA PF01134.17 CCF43080.1 - 0.018 13.9 0.0 0.043 12.6 0.0 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A LigB PF02900.13 CCF43080.1 - 0.032 13.2 0.1 0.073 12.0 0.0 1.5 1 0 0 1 1 1 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase NAD_binding_8 PF13450.1 CCF43080.1 - 0.037 14.0 0.0 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain IlvN PF07991.7 CCF43080.1 - 0.042 13.2 0.0 0.78 9.0 0.0 2.1 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain UDPG_MGDP_dh_N PF03721.9 CCF43080.1 - 0.058 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.11 CCF43080.1 - 0.1 12.0 0.0 0.71 9.3 0.0 2.1 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA ubiquitin PF00240.18 CCF43081.1 - 2.4e-07 30.0 0.2 5.6e-07 28.8 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.4 CCF43081.1 - 7.9e-06 25.9 0.0 2.4e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.3 CCF43081.1 - 0.019 14.6 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like PS_Dcarbxylase PF02666.10 CCF43082.1 - 2.1e-72 242.6 0.0 1.1e-71 240.2 0.0 1.9 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase Biotin_lipoyl PF00364.17 CCF43082.1 - 0.02 14.4 0.0 0.051 13.2 0.0 1.6 1 0 0 1 1 1 0 Biotin-requiring enzyme Nitroreductase PF00881.19 CCF43083.1 - 9.8e-15 54.7 0.0 1.2e-14 54.4 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family COesterase PF00135.23 CCF43084.1 - 3.7e-80 270.1 0.0 4.8e-80 269.7 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF43084.1 - 1.1e-05 25.1 0.1 0.013 15.0 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold 4HB_MCP_1 PF12729.2 CCF43085.1 - 0.012 15.0 0.3 0.012 15.0 0.2 1.7 2 1 0 2 2 2 0 Four helix bundle sensory module for signal transduction SNARE PF05739.14 CCF43085.1 - 0.041 13.5 0.1 0.14 11.8 0.0 1.9 2 0 0 2 2 2 0 SNARE domain Jnk-SapK_ap_N PF09744.4 CCF43085.1 - 0.049 13.6 1.0 0.06 13.3 0.1 1.6 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 GRAB PF10375.4 CCF43087.1 - 6.8e-09 35.0 0.1 1.4e-08 34.0 0.1 1.6 1 0 0 1 1 1 1 GRIP-related Arf-binding domain Filament PF00038.16 CCF43087.1 - 0.0011 18.5 59.6 0.055 12.9 23.3 2.1 1 1 1 2 2 2 2 Intermediate filament protein CENP-F_leu_zip PF10473.4 CCF43087.1 - 0.0017 18.2 31.6 0.0017 18.2 21.9 3.2 1 1 2 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Transposase_22 PF02994.9 CCF43087.1 - 0.002 16.7 16.2 0.002 16.7 11.2 3.6 1 1 2 3 3 3 1 L1 transposable element Reo_sigmaC PF04582.7 CCF43087.1 - 0.0075 15.4 23.2 0.43 9.7 1.7 3.1 1 1 2 3 3 3 3 Reovirus sigma C capsid protein HALZ PF02183.13 CCF43087.1 - 0.01 15.5 1.9 0.01 15.5 1.3 5.8 6 1 1 7 7 6 0 Homeobox associated leucine zipper Tup_N PF08581.5 CCF43087.1 - 0.011 15.9 2.0 0.011 15.9 1.4 4.6 3 1 1 4 4 4 0 Tup N-terminal IncA PF04156.9 CCF43087.1 - 0.027 14.0 67.4 0.38 10.3 16.7 3.3 1 1 2 3 3 3 0 IncA protein BCDHK_Adom3 PF10436.4 CCF43087.1 - 0.096 12.1 3.7 0.21 11.0 0.1 2.7 2 1 0 2 2 2 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase AAA_27 PF13514.1 CCF43087.1 - 0.12 9.9 51.6 0.18 9.4 35.8 1.2 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.3 CCF43087.1 - 0.23 8.7 58.0 0.069 10.4 21.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Atg14 PF10186.4 CCF43087.1 - 0.93 8.3 50.8 7.1 5.4 19.7 3.3 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Spc7 PF08317.6 CCF43087.1 - 1 7.9 54.2 0.36 9.4 6.0 3.2 1 1 0 2 2 2 0 Spc7 kinetochore protein NPV_P10 PF05531.7 CCF43087.1 - 1.3 9.3 21.5 0.18 12.0 0.4 4.8 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein WEMBL PF05701.6 CCF43087.1 - 1.6 7.1 65.5 5.6 5.2 8.4 3.0 1 1 1 2 2 2 0 Weak chloroplast movement under blue light AAA_13 PF13166.1 CCF43087.1 - 1.8 6.8 48.2 0.6 8.4 8.4 3.1 1 1 2 3 3 3 0 AAA domain Fib_alpha PF08702.5 CCF43087.1 - 2 8.5 32.9 0.22 11.6 8.4 3.7 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family Prominin PF05478.6 CCF43087.1 - 2.3 5.6 28.7 2.5 5.5 13.4 2.2 1 1 1 2 2 2 0 Prominin Baculo_PEP_C PF04513.7 CCF43087.1 - 3.6 7.4 24.4 0.3 10.9 2.9 3.9 1 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF641 PF04859.7 CCF43087.1 - 5.3 6.8 39.4 1.2 8.9 1.4 4.2 2 2 1 4 4 4 0 Plant protein of unknown function (DUF641) Mnd1 PF03962.10 CCF43087.1 - 6 6.4 57.0 1.4 8.5 6.1 3.9 1 1 4 5 5 5 0 Mnd1 family Tropomyosin PF00261.15 CCF43087.1 - 7.7 5.5 71.3 31 3.5 33.3 2.9 1 1 1 2 2 2 0 Tropomyosin HAD PF12710.2 CCF43088.1 - 6.1e-30 104.8 0.0 1.1e-29 104.0 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 CCF43088.1 - 2.7e-28 98.5 0.0 4.1e-28 97.9 0.0 1.2 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 CCF43088.1 - 6e-17 62.7 0.0 4.1e-15 56.7 0.0 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF43088.1 - 0.0061 16.4 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 CCF43088.1 - 0.046 13.2 0.2 1.1 8.8 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase TMP-TENI PF02581.12 CCF43089.1 - 1.3e-07 30.9 0.0 1.4e-07 30.8 0.0 1.0 1 0 0 1 1 1 1 Thiamine monophosphate synthase/TENI PGP_phosphatase PF09419.5 CCF43089.1 - 0.14 11.4 0.1 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase Fungal_trans PF04082.13 CCF43090.1 - 0.00042 19.2 0.0 0.00082 18.3 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Methyltransf_23 PF13489.1 CCF43091.1 - 3.3e-20 72.4 0.0 5.6e-20 71.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF43091.1 - 3.5e-13 49.8 0.0 6.7e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF43091.1 - 4.4e-10 39.3 0.0 4.4e-09 36.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF43091.1 - 3.5e-09 37.2 0.0 3.5e-08 33.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF43091.1 - 5.2e-08 33.2 0.0 3.2e-07 30.7 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF43091.1 - 1.6e-06 28.3 0.0 1.7e-05 25.0 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF43091.1 - 1e-05 24.7 0.0 6.1e-05 22.2 0.0 1.9 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 CCF43091.1 - 0.00013 21.0 0.0 0.0011 18.0 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase CMAS PF02353.15 CCF43091.1 - 0.0034 16.5 0.0 0.0057 15.7 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_26 PF13659.1 CCF43091.1 - 0.011 15.8 0.2 0.1 12.6 0.0 2.5 2 1 0 2 2 2 0 Methyltransferase domain FtsJ PF01728.14 CCF43091.1 - 0.015 15.2 0.0 0.041 13.8 0.0 1.7 2 0 0 2 2 2 0 FtsJ-like methyltransferase PrmA PF06325.8 CCF43091.1 - 0.016 14.3 0.0 0.026 13.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 CCF43091.1 - 0.017 14.5 0.0 0.13 11.6 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_2 PF00891.13 CCF43091.1 - 0.14 11.3 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_16 PF10294.4 CCF43091.1 - 0.18 11.2 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Lysine_decarbox PF03641.9 CCF43092.1 - 2.1e-30 105.2 0.0 3.3e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 Possible lysine decarboxylase IMD PF08397.6 CCF43094.1 - 0.00054 19.3 2.3 0.14 11.4 0.3 2.1 1 1 1 2 2 2 2 IRSp53/MIM homology domain MFS_1 PF07690.11 CCF43096.1 - 8.2e-12 44.5 50.6 8.2e-12 44.5 35.1 2.8 1 1 2 3 3 3 2 Major Facilitator Superfamily PQ-loop PF04193.9 CCF43097.1 - 1.8e-41 139.4 8.4 1.7e-20 72.3 0.5 2.6 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.11 CCF43097.1 - 0.12 12.2 0.3 0.12 12.2 0.2 2.4 2 1 0 2 2 2 0 Sugar efflux transporter for intercellular exchange NUDIX PF00293.23 CCF43098.1 - 3.4e-16 59.1 0.0 7.1e-16 58.0 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.6 CCF43098.1 - 3.4e-15 56.1 0.0 1.1e-14 54.5 0.0 1.9 3 0 0 3 3 3 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.6 CCF43098.1 - 7.4e-06 25.3 0.7 1.4e-05 24.5 0.5 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain Arf PF00025.16 CCF43099.1 - 1e-38 132.2 0.0 1.9e-38 131.4 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 CCF43099.1 - 5.5e-14 51.6 0.0 1.8e-09 36.7 0.0 2.0 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.17 CCF43099.1 - 1.2e-08 34.5 0.0 2.9e-08 33.2 0.0 1.6 1 1 0 1 1 1 1 Ras family Gtr1_RagA PF04670.7 CCF43099.1 - 5.1e-08 32.3 0.0 6.1e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 CCF43099.1 - 2.4e-07 30.1 0.0 5.6e-07 28.9 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Miro PF08477.8 CCF43099.1 - 9.1e-06 26.1 0.0 3.4e-05 24.3 0.0 1.9 1 1 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 CCF43099.1 - 3e-05 23.5 0.0 9.9e-05 21.8 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CCF43099.1 - 0.0018 18.1 0.0 0.0028 17.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RNase_PH PF01138.16 CCF43100.1 - 1.2e-21 77.3 0.0 2e-21 76.7 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 CCF43100.1 - 3.4e-06 26.8 0.0 5.7e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Cwf_Cwc_15 PF04889.7 CCF43101.1 - 1.4e-84 283.6 19.5 1.5e-84 283.5 13.5 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein GEMIN8 PF15348.1 CCF43101.1 - 0.0078 16.2 11.2 0.0095 16.0 7.7 1.2 1 0 0 1 1 1 1 Gemini of Cajal bodies-associated protein 8 CDC27 PF09507.5 CCF43101.1 - 0.13 11.4 15.7 0.16 11.1 10.9 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Nop53 PF07767.6 CCF43101.1 - 0.22 10.4 22.1 0.33 9.8 15.3 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) SDA1 PF05285.7 CCF43101.1 - 0.27 10.5 24.7 0.33 10.1 17.1 1.2 1 0 0 1 1 1 0 SDA1 DDHD PF02862.12 CCF43101.1 - 0.41 10.4 3.9 0.5 10.1 2.7 1.2 1 0 0 1 1 1 0 DDHD domain Nop14 PF04147.7 CCF43101.1 - 0.49 8.2 24.6 0.58 8.0 17.0 1.2 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 CCF43101.1 - 0.78 7.6 20.8 1 7.3 14.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1510 PF07423.6 CCF43101.1 - 2.6 7.3 19.9 4 6.7 13.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF2890 PF11081.3 CCF43101.1 - 2.8 7.9 21.4 4.2 7.3 14.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2890) Tom37_C PF11801.3 CCF43101.1 - 4.5 7.0 5.9 7.5 6.3 4.1 1.5 1 0 0 1 1 1 0 Tom37 C-terminal domain Hex_IIIa PF02455.11 CCF43101.1 - 6.3 5.3 9.2 7.3 5.1 6.4 1.1 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) Daxx PF03344.10 CCF43101.1 - 8.5 4.7 21.2 10 4.4 14.7 1.2 1 0 0 1 1 1 0 Daxx Family DUF3381 PF11861.3 CCF43101.1 - 9.3 5.7 21.4 20 4.6 14.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Benyvirus_14KDa PF07255.6 CCF43103.1 - 0.087 12.7 0.2 0.12 12.2 0.1 1.1 1 0 0 1 1 1 0 Benyvirus 14KDa protein SRF-TF PF00319.13 CCF43104.1 - 1.6e-23 81.6 0.3 2.2e-23 81.2 0.2 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) CDC45 PF02724.9 CCF43104.1 - 0.022 12.8 0.4 0.026 12.5 0.3 1.1 1 0 0 1 1 1 0 CDC45-like protein LRS4 PF10422.4 CCF43105.1 - 1.5e-05 24.4 3.0 2e-05 24.0 2.1 1.1 1 0 0 1 1 1 1 Monopolin complex subunit LRS4 Pox_Ag35 PF03286.9 CCF43105.1 - 0.049 13.1 5.0 0.069 12.6 3.5 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Nucleo_P87 PF07267.6 CCF43105.1 - 0.075 11.7 0.6 0.083 11.5 0.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 ASFV_J13L PF05568.6 CCF43105.1 - 0.31 10.5 3.3 0.39 10.2 2.3 1.1 1 0 0 1 1 1 0 African swine fever virus J13L protein zf-CCHC PF00098.18 CCF43107.1 - 2.3e-21 74.5 30.0 1e-06 28.3 0.7 4.2 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_2 PF13696.1 CCF43107.1 - 0.00012 21.5 22.3 0.0024 17.3 0.3 5.1 2 1 3 5 5 5 4 Zinc knuckle zf-CCHC_4 PF14392.1 CCF43107.1 - 0.00032 20.3 23.1 0.011 15.3 0.8 4.3 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_3 PF13917.1 CCF43107.1 - 0.11 12.2 21.1 4.1 7.2 1.3 4.2 1 1 3 4 4 4 0 Zinc knuckle GFA PF04828.9 CCF43108.1 - 0.00021 21.1 0.0 0.00042 20.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme zf-ribbon_3 PF13248.1 CCF43108.1 - 0.093 11.9 0.5 0.093 11.9 0.3 1.6 2 0 0 2 2 2 0 zinc-ribbon domain DUF2407_C PF13373.1 CCF43109.1 - 0.09 12.6 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 DUF2407 C-terminal domain PT PF04886.7 CCF43110.1 - 1.8 7.9 14.2 0.2 10.9 3.8 2.8 2 2 0 2 2 2 0 PT repeat MGC-24 PF05283.6 CCF43111.1 - 0.048 13.4 5.8 0.063 13.0 4.0 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) DUF4215 PF13948.1 CCF43111.1 - 0.084 13.1 1.1 0.15 12.3 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4215) DUF1180 PF06679.7 CCF43111.1 - 4.4 7.1 6.6 7.1 6.4 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Gag_spuma PF03276.9 CCF43112.1 - 0.0012 17.3 2.1 0.0019 16.6 1.4 1.2 1 0 0 1 1 1 1 Spumavirus gag protein AT_hook PF02178.14 CCF43112.1 - 0.018 14.6 1.7 0.043 13.4 1.2 1.7 1 0 0 1 1 1 0 AT hook motif PP_M1 PF03012.9 CCF43112.1 - 0.13 11.5 4.5 0.2 10.9 3.1 1.2 1 0 0 1 1 1 0 Phosphoprotein MSA-2c PF12238.3 CCF43112.1 - 0.14 11.7 2.3 0.33 10.5 1.6 1.6 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF2027 PF09640.5 CCF43113.1 - 0.063 12.6 0.0 0.1 11.9 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF2027) Sugar_tr PF00083.19 CCF43114.1 - 4e-77 259.7 20.4 4.6e-77 259.5 14.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF43114.1 - 5.5e-13 48.3 20.1 5.5e-13 48.3 13.9 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily Tmemb_18A PF09771.4 CCF43114.1 - 0.096 12.6 0.1 0.26 11.2 0.1 1.7 1 0 0 1 1 1 0 Transmembrane protein 188 MFS_1 PF07690.11 CCF43117.1 - 3e-32 111.6 30.4 3e-32 111.6 21.1 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF43117.1 - 1.8e-10 40.0 31.8 9.7e-09 34.2 22.0 3.1 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 CCF43117.1 - 0.00053 18.3 4.5 0.00053 18.3 3.2 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) PT-VENN PF04829.8 CCF43117.1 - 3.9 7.0 5.2 2.5 7.7 0.6 2.4 2 0 0 2 2 2 0 Pre-toxin domain with VENN motif DUF4267 PF14087.1 CCF43118.1 - 5.9e-12 45.1 1.2 8e-12 44.7 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) PNP_UDP_1 PF01048.15 CCF43120.1 - 1.3e-09 37.4 0.1 3.4e-09 36.0 0.0 1.7 1 1 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.7 CCF43120.1 - 1.2e-07 31.5 0.0 2e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 CCF43120.1 - 8.4e-06 25.8 0.0 2.1e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CCF43120.1 - 6.3e-05 23.1 0.0 0.00014 22.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mito_fiss_reg PF05308.6 CCF43120.1 - 0.0052 16.1 1.6 0.009 15.4 1.1 1.3 1 0 0 1 1 1 1 Mitochondrial fission regulator AFG1_ATPase PF03969.11 CCF43120.1 - 0.025 13.3 0.4 0.098 11.4 0.2 1.9 2 0 0 2 2 2 0 AFG1-like ATPase AAA_10 PF12846.2 CCF43120.1 - 0.05 13.0 0.4 0.37 10.1 0.3 2.3 3 0 0 3 3 3 0 AAA-like domain KAP_NTPase PF07693.9 CCF43120.1 - 0.051 12.5 0.8 1.7 7.5 0.0 2.1 2 0 0 2 2 2 0 KAP family P-loop domain ABC_tran PF00005.22 CCF43120.1 - 0.14 12.4 0.1 0.34 11.2 0.1 1.6 1 0 0 1 1 1 0 ABC transporter CAP_N PF01213.14 CCF43120.1 - 0.41 9.8 1.9 0.71 9.0 1.3 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Pex14_N PF04695.8 CCF43121.1 - 1.1 9.2 11.1 0.056 13.4 1.5 2.1 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region UFD1 PF03152.9 CCF43122.1 - 7.9e-22 77.2 0.0 1.3e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 ELO PF01151.13 CCF43123.1 - 1.9e-82 276.3 12.1 2.3e-82 276.0 8.4 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family O-FucT PF10250.4 CCF43124.1 - 9.6e-08 31.5 0.0 5.2e-07 29.1 0.0 1.9 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase TPR_12 PF13424.1 CCF43125.1 - 9e-05 22.3 1.1 0.00037 20.3 0.1 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 CCF43125.1 - 0.00012 21.4 0.4 0.0031 17.0 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 CCF43125.1 - 0.00037 20.2 0.9 0.0015 18.3 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 CCF43125.1 - 0.0024 17.5 0.0 0.0088 15.7 0.0 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat Gemin6 PF06372.7 CCF43125.1 - 0.0037 16.6 0.1 0.73 9.1 0.0 2.3 2 0 0 2 2 2 2 Gemin6 protein TPR_19 PF14559.1 CCF43125.1 - 0.0079 16.5 1.9 0.033 14.5 0.2 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 CCF43125.1 - 0.024 14.2 0.1 0.12 12.0 0.1 2.1 1 1 0 1 1 1 0 TPR repeat Ank_4 PF13637.1 CCF43125.1 - 0.052 14.0 0.0 0.21 12.1 0.0 2.1 2 0 0 2 2 1 0 Ankyrin repeats (many copies) FCP1_C PF09309.5 CCF43125.1 - 0.057 12.7 0.1 0.1 11.8 0.1 1.3 1 0 0 1 1 1 0 FCP1, C-terminal Ank_2 PF12796.2 CCF43125.1 - 0.069 13.5 0.0 0.19 12.0 0.0 1.8 2 0 0 2 2 1 0 Ankyrin repeats (3 copies) TPR_10 PF13374.1 CCF43125.1 - 0.2 11.6 0.0 0.2 11.6 0.0 2.6 2 0 0 2 2 1 0 Tetratricopeptide repeat AMP-binding PF00501.23 CCF43126.1 - 2.7e-47 161.1 0.0 3e-47 160.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme Repressor_Mnt PF11423.3 CCF43126.1 - 0.34 10.2 1.3 0.79 9.0 0.9 1.5 1 0 0 1 1 1 0 Regulatory protein Mnt AAA_23 PF13476.1 CCF43127.1 - 3e-17 63.6 31.1 3.9e-11 43.6 17.4 4.0 2 1 0 2 2 2 2 AAA domain SMC_N PF02463.14 CCF43127.1 - 3.2e-13 49.4 6.2 3.2e-13 49.4 4.3 1.6 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF43127.1 - 0.00039 20.4 0.0 0.00091 19.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 CCF43127.1 - 0.0044 16.5 0.0 0.0092 15.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain CENP-F_leu_zip PF10473.4 CCF43127.1 - 0.0067 16.2 0.5 0.0067 16.2 0.3 4.3 2 1 0 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA PF00004.24 CCF43127.1 - 0.0078 16.4 0.1 0.15 12.2 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Reo_sigmaC PF04582.7 CCF43127.1 - 0.015 14.4 0.3 2.5 7.2 0.0 2.8 3 0 0 3 3 3 0 Reovirus sigma C capsid protein AAA_25 PF13481.1 CCF43127.1 - 0.018 14.4 0.8 0.081 12.3 0.0 2.5 2 1 1 3 3 3 0 AAA domain V_ATPase_I PF01496.14 CCF43127.1 - 3.3 5.4 33.5 0.33 8.7 6.4 3.1 2 1 1 3 3 3 0 V-type ATPase 116kDa subunit family SNARE PF05739.14 CCF43128.1 - 3.5e-07 29.7 0.3 3.8e-07 29.6 0.2 1.0 1 0 0 1 1 1 1 SNARE domain DUF1488 PF07369.6 CCF43128.1 - 0.088 12.6 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1488) Use1 PF09753.4 CCF43128.1 - 0.13 11.7 0.1 0.14 11.5 0.1 1.0 1 0 0 1 1 1 0 Membrane fusion protein Use1 Apc15p PF05841.6 CCF43129.1 - 8.9e-20 71.6 6.7 1.7e-19 70.7 4.6 1.5 1 0 0 1 1 1 1 Apc15p protein DUF4148 PF13663.1 CCF43129.1 - 0.15 11.9 2.6 0.5 10.2 1.8 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) Abhydrolase_3 PF07859.8 CCF43130.1 - 2.4e-22 79.5 0.1 3.5e-22 79.0 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2424 PF10340.4 CCF43130.1 - 1e-14 53.9 0.0 1.4e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 CCF43130.1 - 0.023 14.4 0.2 0.048 13.4 0.1 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family adh_short PF00106.20 CCF43131.1 - 5.5e-25 88.2 0.0 1.2e-24 87.1 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF43131.1 - 2.7e-08 33.6 0.6 1.5e-07 31.3 0.0 2.3 2 1 0 2 2 2 1 KR domain DUF1776 PF08643.5 CCF43131.1 - 2e-05 23.8 0.1 4.1e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.16 CCF43131.1 - 0.00013 21.4 0.0 0.00018 21.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF43131.1 - 0.012 15.6 0.0 0.026 14.5 0.0 1.7 1 1 0 1 1 1 0 NADH(P)-binding 3Beta_HSD PF01073.14 CCF43131.1 - 0.018 13.7 0.0 0.027 13.1 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family TraC_F_IV PF11130.3 CCF43131.1 - 0.022 14.2 0.0 0.033 13.6 0.0 1.3 1 0 0 1 1 1 0 F pilus assembly Type-IV secretion system for plasmid transfer Eno-Rase_NADH_b PF12242.3 CCF43131.1 - 0.086 12.6 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Pyr_redox_3 PF13738.1 CCF43132.1 - 3.8e-14 53.2 0.0 8.4e-14 52.1 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF43132.1 - 6.5e-07 29.2 0.0 1.8e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.14 CCF43132.1 - 4.5e-06 25.1 0.0 7.1e-06 24.5 0.0 1.3 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.1 CCF43132.1 - 0.00026 20.0 0.0 0.02 13.7 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.19 CCF43132.1 - 0.0047 15.8 0.0 0.0086 15.0 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Fungal_trans PF04082.13 CCF43133.1 - 3.2e-19 68.8 0.0 3e-18 65.6 0.0 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF1195 PF06708.6 CCF43133.1 - 0.066 12.6 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1195) p450 PF00067.17 CCF43134.1 - 1.2e-53 182.2 0.0 1.6e-53 181.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Atg8 PF02991.11 CCF43135.1 - 2.7e-36 123.6 3.4 3.9e-33 113.5 0.1 2.1 2 0 0 2 2 2 2 Autophagy protein Atg8 ubiquitin like APG12 PF04110.8 CCF43135.1 - 0.00069 19.7 0.0 0.00096 19.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Glyco_hydro_61 PF03443.9 CCF43136.1 - 4.7e-39 134.4 0.0 5.2e-39 134.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 SnoaL_2 PF12680.2 CCF43137.1 - 0.00032 21.0 0.3 0.00059 20.2 0.2 1.4 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.7 CCF43137.1 - 0.00039 20.0 0.1 0.00057 19.4 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase Cyto_heme_lyase PF01265.12 CCF43139.1 - 1.5e-34 119.7 24.1 1.5e-30 106.6 11.5 2.0 1 1 1 2 2 2 2 Cytochrome c/c1 heme lyase Mito_carr PF00153.22 CCF43141.1 - 9.5e-58 191.9 3.7 2e-19 69.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DOPA_dioxygen PF08883.6 CCF43142.1 - 1e-25 89.7 0.0 1.3e-25 89.4 0.0 1.1 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family IMS PF00817.15 CCF43143.1 - 1.1e-36 125.8 0.0 2e-36 125.0 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 CCF43143.1 - 9.6e-08 32.0 0.0 1.7e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 CCF43143.1 - 0.054 13.5 0.0 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 IMS family HHH motif Sugar_tr PF00083.19 CCF43144.1 - 3e-66 223.8 26.5 7.8e-60 202.7 14.1 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 CCF43144.1 - 5.3e-25 87.8 32.6 9.3e-25 87.0 20.7 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily CoaE PF01121.15 CCF43144.1 - 0.035 13.5 0.0 0.05 13.0 0.0 1.2 1 0 0 1 1 1 0 Dephospho-CoA kinase TPR_19 PF14559.1 CCF43144.1 - 0.073 13.4 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Chorein_N PF12624.2 CCF43146.1 - 3.5e-42 142.6 0.0 1.2e-41 140.9 0.0 2.0 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter DUF3429 PF11911.3 CCF43147.1 - 3.8e-40 137.1 5.6 5.3e-40 136.6 3.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) Ycf1 PF05758.7 CCF43147.1 - 0.17 9.5 7.9 0.23 9.1 5.5 1.2 1 0 0 1 1 1 0 Ycf1 DUF1510 PF07423.6 CCF43147.1 - 0.89 8.8 24.8 0.032 13.5 12.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Neur_chan_memb PF02932.11 CCF43147.1 - 1.5 8.6 4.0 0.45 10.3 0.8 1.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF3129 PF11327.3 CCF43148.1 - 1.9e-32 112.5 10.7 1.9e-32 112.5 7.4 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF3129) V-set PF07686.12 CCF43148.1 - 0.063 13.1 0.1 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin V-set domain PAT1 PF09770.4 CCF43148.1 - 0.62 8.2 8.7 0.76 7.9 6.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MSP1_C PF07462.6 CCF43148.1 - 3.7 5.8 5.1 5.7 5.2 3.6 1.3 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus But2 PF09792.4 CCF43149.1 - 6.9e-24 84.2 1.1 1.2e-23 83.4 0.3 1.7 2 1 1 3 3 3 1 Ubiquitin 3 binding protein But2 C-terminal domain Cation_efflux PF01545.16 CCF43150.1 - 1.4e-06 27.5 0.1 1.6e-06 27.4 0.1 1.1 1 0 0 1 1 1 1 Cation efflux family FGGY_N PF00370.16 CCF43151.1 - 1.8e-20 73.3 0.0 1.8e-11 43.8 0.0 2.2 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.11 CCF43151.1 - 3.8e-08 33.1 0.0 7.8e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain SRP-alpha_N PF04086.8 CCF43151.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal WH1 PF00568.18 CCF43153.1 - 4.9e-18 64.8 0.1 5.9e-18 64.6 0.1 1.1 1 0 0 1 1 1 1 WH1 domain Esterase_phd PF10503.4 CCF43154.1 - 2.2e-21 76.0 0.7 3.1e-21 75.6 0.5 1.2 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.16 CCF43154.1 - 9.7e-09 34.7 0.1 1.7e-08 33.9 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CCF43154.1 - 2e-06 27.6 0.2 2.9e-06 27.0 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF43154.1 - 4.1e-05 23.5 0.2 6.5e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family COesterase PF00135.23 CCF43154.1 - 0.00098 17.9 0.1 0.0015 17.3 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Esterase PF00756.15 CCF43154.1 - 0.0027 17.1 0.1 0.0031 16.9 0.1 1.2 1 0 0 1 1 1 1 Putative esterase Abhydrolase_1 PF00561.15 CCF43154.1 - 0.0082 15.7 0.3 0.019 14.5 0.2 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.8 CCF43154.1 - 0.0084 15.7 0.1 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 CCF43154.1 - 0.021 14.2 0.0 1.5 8.1 0.1 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase LIP PF03583.9 CCF43154.1 - 0.059 12.5 1.4 2.5 7.2 0.0 2.1 1 1 1 2 2 2 0 Secretory lipase Fungal_trans PF04082.13 CCF43155.1 - 2.9e-14 52.5 0.8 4e-14 52.1 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Cpn60_TCP1 PF00118.19 CCF43156.1 - 5.6e-136 453.9 7.9 6.6e-136 453.7 5.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family GARS_C PF02843.11 CCF43156.1 - 0.061 13.5 0.4 0.32 11.1 0.0 2.4 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, C domain FumaraseC_C PF10415.4 CCF43157.1 - 7e-24 83.6 0.0 8.4e-24 83.4 0.0 1.1 1 0 0 1 1 1 1 Fumarase C C-terminus Metallophos PF00149.23 CCF43158.1 - 3.7e-10 39.5 0.2 5.2e-09 35.7 0.1 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CCF43158.1 - 2.2e-06 27.5 0.0 5.5e-06 26.3 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Zip PF02535.17 CCF43160.1 - 3.9e-34 118.1 11.8 2.1e-33 115.6 8.2 1.9 1 1 0 1 1 1 1 ZIP Zinc transporter SOG2 PF10428.4 CCF43160.1 - 0.38 9.3 6.3 0.047 12.3 1.3 1.6 1 1 0 1 1 1 0 RAM signalling pathway protein WSC PF01822.14 CCF43161.1 - 1.7e-14 53.4 6.0 1.7e-14 53.4 4.2 2.0 2 0 0 2 2 2 1 WSC domain Guanylate_cyc PF00211.15 CCF43161.1 - 0.16 11.3 0.2 0.25 10.6 0.1 1.2 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain Metallophos PF00149.23 CCF43162.1 - 3.8e-10 39.5 5.0 3.8e-06 26.4 0.2 2.4 2 1 0 2 2 2 2 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CCF43162.1 - 1.3e-05 25.1 0.1 2.2e-05 24.3 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Anoctamin PF04547.7 CCF43163.1 - 4.2e-121 404.7 7.2 5.2e-121 404.4 5.0 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel SH3_9 PF14604.1 CCF43164.1 - 4e-12 45.5 0.5 4e-12 45.5 0.3 1.8 2 0 0 2 2 2 1 Variant SH3 domain P-mevalo_kinase PF04275.9 CCF43164.1 - 0.15 11.7 0.3 0.41 10.3 0.1 1.7 2 0 0 2 2 2 0 Phosphomevalonate kinase Cyt-b5 PF00173.23 CCF43165.1 - 1.2e-23 82.6 0.0 2.1e-23 81.9 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain BNR PF02012.15 CCF43166.1 - 4.4e-12 43.8 18.8 0.2 11.5 0.0 7.4 6 0 0 6 6 6 5 BNR/Asp-box repeat PSII_BNR PF14870.1 CCF43166.1 - 5.5e-06 25.5 1.5 0.013 14.4 0.0 4.1 3 1 1 4 4 4 2 Photosynthesis system II assembly factor YCF48 BNR_2 PF13088.1 CCF43166.1 - 1.4e-05 24.5 1.5 0.7 9.1 0.0 4.4 4 1 0 4 4 4 2 BNR repeat-like domain Mago-bind PF09282.5 CCF43167.1 - 1.2e-13 50.3 3.7 2.1e-13 49.5 2.5 1.4 1 0 0 1 1 1 1 Mago binding RR_TM4-6 PF06459.7 CCF43167.1 - 0.37 10.6 11.6 0.56 10.0 8.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peptidase_A21 PF03566.8 CCF43167.1 - 0.71 7.8 4.1 0.85 7.6 2.8 1.1 1 0 0 1 1 1 0 Peptidase family A21 Menin PF05053.8 CCF43167.1 - 3.1 5.8 7.0 3.5 5.6 4.9 1.1 1 0 0 1 1 1 0 Menin MRL1 PF13003.2 CCF43167.1 - 7.4 6.4 6.8 0.46 10.3 0.3 2.0 2 0 0 2 2 2 0 Ribosomal protein L1 E1-E2_ATPase PF00122.15 CCF43169.1 - 1.2e-60 204.4 2.1 1.2e-60 204.4 1.5 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CCF43169.1 - 1.2e-45 155.2 2.3 1.2e-45 155.2 1.6 2.8 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CCF43169.1 - 1.1e-28 101.1 0.0 9.3e-28 98.1 0.0 2.4 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF43169.1 - 3.4e-20 71.8 0.0 1.1e-19 70.2 0.0 1.9 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 CCF43169.1 - 1.2e-15 58.1 0.0 3.1e-15 56.8 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 CCF43169.1 - 2.5e-08 33.2 0.4 1.6e-07 30.6 0.0 2.5 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 CCF43169.1 - 1.8e-06 27.7 0.6 0.00019 21.0 0.3 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase UCR_UQCRX_QCR9 PF05365.7 CCF43170.1 - 4.6e-16 58.1 0.9 5e-16 58.0 0.6 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Tricorn_C1 PF14684.1 CCF43170.1 - 0.081 12.8 0.7 0.093 12.6 0.5 1.1 1 0 0 1 1 1 0 Tricorn protease C1 domain Ribonuc_L-PSP PF01042.16 CCF43171.1 - 2.3e-40 137.1 0.0 2.8e-40 136.8 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP PMT PF02366.13 CCF43172.1 - 3.5e-81 272.1 19.0 6.6e-81 271.2 13.2 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 CCF43172.1 - 1.3e-20 73.7 1.0 1.9e-19 69.9 0.1 2.1 1 1 1 2 2 2 2 MIR domain DUF334 PF03904.8 CCF43172.1 - 1.3 8.2 2.7 0.55 9.5 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF334) CAP59_mtransfer PF11735.3 CCF43173.1 - 3.4e-83 278.5 0.0 4.5e-83 278.1 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Abhydrolase_3 PF07859.8 CCF43174.1 - 4.1e-11 42.8 0.0 4.8e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Pkinase PF00069.20 CCF43175.1 - 9.7e-05 21.6 0.0 0.00043 19.5 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF43175.1 - 0.07 12.1 0.9 0.39 9.7 0.6 1.9 1 1 0 1 1 1 0 Protein tyrosine kinase GRP PF07172.6 CCF43176.1 - 0.18 12.2 10.4 0.22 12.0 7.2 1.2 1 0 0 1 1 1 0 Glycine rich protein family DUF4367 PF14285.1 CCF43177.1 - 0.0079 15.5 0.0 0.0095 15.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4367) Ribosomal_S27 PF01599.14 CCF43177.1 - 5.4 6.9 7.6 4.1 7.3 1.0 2.5 3 0 0 3 3 3 0 Ribosomal protein S27a Mito_carr PF00153.22 CCF43178.1 - 6.1e-53 176.5 5.4 3.2e-18 65.2 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein UcrQ PF02939.11 CCF43178.1 - 0.00069 19.3 0.2 0.002 17.9 0.1 1.9 2 0 0 2 2 2 1 UcrQ family Frag1 PF10277.4 CCF43178.1 - 0.025 14.0 0.0 0.04 13.3 0.0 1.4 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family Fungal_trans PF04082.13 CCF43180.1 - 1.7e-28 99.2 0.0 3.4e-28 98.2 0.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF43180.1 - 2.4e-09 36.9 7.6 3.9e-09 36.2 5.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tropomyosin PF00261.15 CCF43181.1 - 0.04 13.0 31.1 0.018 14.1 9.6 2.6 1 1 1 2 2 2 0 Tropomyosin Tropomyosin_1 PF12718.2 CCF43181.1 - 0.068 13.0 32.8 0.17 11.7 11.3 2.8 2 1 1 3 3 3 0 Tropomyosin like DivIVA PF05103.8 CCF43181.1 - 0.22 11.5 27.0 6.8 6.7 0.1 4.2 2 1 2 4 4 4 0 DivIVA protein TMCO5 PF14992.1 CCF43181.1 - 1.2 8.2 14.1 2 7.4 9.8 1.4 1 0 0 1 1 1 0 TMCO5 family AAA_13 PF13166.1 CCF43181.1 - 2.7 6.3 11.4 4.7 5.5 7.9 1.4 1 0 0 1 1 1 0 AAA domain ADIP PF11559.3 CCF43181.1 - 3.3 7.6 31.3 0.047 13.5 7.9 3.2 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.6 CCF43181.1 - 5.7 6.7 31.1 0.81 9.4 5.9 3.4 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Myb_DNA-binding PF00249.26 CCF43182.1 - 3.6e-21 74.9 0.7 3.4e-11 43.0 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CCF43182.1 - 1e-18 67.1 1.3 1.1e-13 51.0 0.0 2.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain DUF2774 PF11242.3 CCF43182.1 - 0.018 15.0 0.0 0.16 11.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2774) HTH_23 PF13384.1 CCF43182.1 - 0.035 13.7 0.9 0.23 11.1 0.5 2.2 2 0 0 2 2 2 0 Homeodomain-like domain Pkinase PF00069.20 CCF43183.1 - 1.1e-64 218.0 0.0 1.3e-64 217.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF43183.1 - 5e-31 107.7 0.0 6.3e-31 107.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF43183.1 - 0.00014 20.9 0.0 0.00022 20.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CCF43183.1 - 0.0069 16.1 0.1 0.023 14.4 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 CCF43183.1 - 0.088 11.6 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Phage-MuB_C PF09077.6 CCF43187.1 - 0.11 12.1 0.9 4.2 7.1 0.0 2.7 3 0 0 3 3 3 0 Mu B transposition protein, C terminal AMP-binding PF00501.23 CCF43188.1 - 4.2e-78 262.6 0.0 8.9e-78 261.5 0.0 1.6 2 0 0 2 2 2 1 AMP-binding enzyme NAD_binding_4 PF07993.7 CCF43188.1 - 1.3e-66 224.0 0.0 2e-66 223.4 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.16 CCF43188.1 - 2.5e-12 46.7 0.0 1e-11 44.7 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF43188.1 - 2.2e-10 39.7 0.0 7.9e-10 37.8 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family PP-binding PF00550.20 CCF43188.1 - 1.1e-08 35.1 0.0 2.8e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site NAD_binding_10 PF13460.1 CCF43188.1 - 7.5e-07 29.3 0.0 0.00019 21.5 0.0 3.3 2 1 0 2 2 2 1 NADH(P)-binding AMP-binding_C PF13193.1 CCF43188.1 - 1.2e-05 26.1 0.0 0.00023 22.0 0.0 3.2 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain RmlD_sub_bind PF04321.12 CCF43188.1 - 0.059 12.2 0.0 5.3 5.8 0.0 2.4 2 0 0 2 2 2 0 RmlD substrate binding domain DUF1667 PF07892.6 CCF43188.1 - 0.093 12.4 0.0 4.3 7.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1667) Ala_racemase_N PF01168.15 CCF43189.1 - 1.7e-38 132.3 0.7 2.1e-38 132.0 0.5 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Abhydrolase_6 PF12697.2 CCF43191.1 - 7.4e-10 39.0 0.9 9.7e-10 38.7 0.6 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF43191.1 - 1.8e-06 27.7 0.0 3.2e-06 26.9 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 CCF43191.1 - 0.0043 17.3 0.0 0.0077 16.4 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_1 PF00561.15 CCF43191.1 - 0.012 15.2 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold WSC PF01822.14 CCF43192.1 - 5.5e-11 42.2 8.5 1.2e-10 41.1 5.9 1.6 1 0 0 1 1 1 1 WSC domain SKG6 PF08693.5 CCF43192.1 - 0.00048 19.3 5.2 0.00048 19.3 3.6 1.7 2 0 0 2 2 2 1 Transmembrane alpha-helix domain DUF4366 PF14283.1 CCF43192.1 - 0.034 13.5 0.1 0.13 11.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Hydantoinase_B PF02538.9 CCF43193.1 - 2.7e-117 392.1 0.0 3.4e-117 391.8 0.0 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.13 CCF43193.1 - 1.7e-70 237.4 0.1 2.6e-70 236.7 0.0 1.3 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Proteasome_A_N PF10584.4 CCF43193.1 - 0.032 13.5 0.1 0.071 12.4 0.1 1.5 1 0 0 1 1 1 0 Proteasome subunit A N-terminal signature DUF3039 PF11238.3 CCF43195.1 - 0.015 14.7 0.0 0.033 13.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3039) AATF-Che1 PF13339.1 CCF43195.1 - 0.022 14.9 0.6 0.84 9.7 0.2 2.2 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor HAUS6_N PF14661.1 CCF43195.1 - 0.073 12.4 0.5 0.11 11.7 0.3 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus TelA PF05816.6 CCF43195.1 - 0.075 11.7 0.6 0.12 11.0 0.4 1.3 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) TMF_DNA_bd PF12329.3 CCF43195.1 - 0.21 11.3 1.4 0.4 10.5 1.0 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Ax_dynein_light PF10211.4 CCF43195.1 - 0.23 11.2 0.9 0.37 10.6 0.6 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain Glyco_transf_22 PF03901.12 CCF43196.1 - 9.2e-10 38.0 0.1 1.1e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family UPF0121 PF03661.8 CCF43197.1 - 9.2e-07 28.2 4.4 1.3e-06 27.8 3.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) TGT PF01702.13 CCF43197.1 - 0.084 12.1 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Queuine tRNA-ribosyltransferase AA_kinase PF00696.23 CCF43199.1 - 1.1e-07 31.6 0.2 2.3e-07 30.6 0.1 1.5 1 1 0 1 1 1 1 Amino acid kinase family DUF3662 PF12401.3 CCF43199.1 - 0.0059 16.7 0.1 0.009 16.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2662) SapB_1 PF05184.10 CCF43199.1 - 0.018 14.8 0.8 0.071 12.9 0.3 2.2 2 0 0 2 2 2 0 Saposin-like type B, region 1 DUF3328 PF11807.3 CCF43200.1 - 6.9e-48 163.1 0.6 9.2e-48 162.7 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) PseudoU_synth_2 PF00849.17 CCF43201.1 - 3.5e-31 108.2 0.0 5.3e-31 107.6 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase Ub-Mut7C PF14451.1 CCF43201.1 - 0.0028 17.1 0.1 0.0067 15.9 0.1 1.5 1 0 0 1 1 1 1 Mut7-C ubiquitin PAS_4 PF08448.5 CCF43201.1 - 0.044 13.8 0.0 0.15 12.1 0.0 1.9 1 0 0 1 1 1 0 PAS fold 4HBT PF03061.17 CCF43202.1 - 1.5e-08 34.6 0.0 2.1e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_2 PF13279.1 CCF43202.1 - 0.0019 18.6 0.0 0.0023 18.3 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily GFO_IDH_MocA PF01408.17 CCF43203.1 - 6.8e-19 68.5 0.0 1.2e-18 67.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 CCF43203.1 - 0.0085 15.8 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain MatE PF01554.13 CCF43204.1 - 3.1e-50 169.9 24.9 8.3e-29 100.2 2.9 2.6 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.1 CCF43204.1 - 3.4e-07 30.1 6.9 3.4e-07 30.1 4.8 4.4 3 2 0 4 4 4 2 Polysaccharide biosynthesis C-terminal domain Pkinase PF00069.20 CCF43205.1 - 2.3e-55 187.5 4.6 1.7e-39 135.5 0.1 2.8 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 CCF43205.1 - 1.3e-26 93.2 0.1 2.3e-20 72.7 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 CCF43205.1 - 9.1e-05 21.5 0.3 0.00019 20.4 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 CCF43205.1 - 0.00055 19.0 0.0 0.0012 17.9 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CCF43205.1 - 0.0027 17.4 5.0 0.016 14.9 0.2 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 CCF43205.1 - 0.04 12.7 0.1 0.064 12.0 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Seadorna_VP7 PF07387.6 CCF43205.1 - 0.074 11.8 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.17 CCF43205.1 - 0.078 12.3 1.4 0.44 9.8 0.0 2.2 2 0 0 2 2 2 0 RIO1 family NPP1 PF05630.6 CCF43207.1 - 5.8e-52 176.4 0.1 1.5e-45 155.5 0.0 2.0 1 1 1 2 2 2 2 Necrosis inducing protein (NPP1) IBR PF01485.16 CCF43208.1 - 4.1e-22 77.8 42.6 1.4e-10 40.8 2.6 4.6 3 1 1 4 4 4 3 IBR domain zf-C3HC4 PF00097.20 CCF43208.1 - 6.4e-07 28.9 38.8 0.00041 19.9 4.1 4.6 3 1 1 4 4 4 3 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF43208.1 - 5.5e-06 26.1 41.5 8.1e-05 22.3 4.0 3.7 2 1 1 3 3 3 2 Ring finger domain zf-C3HC4_2 PF13923.1 CCF43208.1 - 1.8e-05 24.6 7.7 1.8e-05 24.6 5.3 4.7 2 1 1 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF43208.1 - 0.012 15.3 8.0 0.012 15.3 5.5 3.8 3 1 0 3 3 3 0 zinc-RING finger domain UN_NPL4 PF11543.3 CCF43208.1 - 0.014 15.6 0.0 0.033 14.4 0.0 1.6 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 zf-RING_UBOX PF13445.1 CCF43208.1 - 1 9.1 22.7 0.14 11.9 2.0 3.8 3 0 0 3 3 3 0 RING-type zinc-finger zf-C3HC4_4 PF15227.1 CCF43208.1 - 1.1 9.1 36.9 0.35 10.7 2.2 5.1 4 1 0 4 4 4 0 zinc finger of C3HC4-type, RING Asp PF00026.18 CCF43209.1 - 5.8e-77 259.0 12.8 6.7e-77 258.8 8.9 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CCF43209.1 - 7.9e-09 35.6 2.8 4.5e-08 33.2 0.2 2.9 1 1 1 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 CCF43209.1 - 0.0071 16.8 3.0 0.092 13.2 0.7 2.7 2 1 0 2 2 2 1 Aspartyl protease CDC37_N PF03234.9 CCF43210.1 - 2.7e-41 141.8 0.4 3e-41 141.6 0.3 1.0 1 0 0 1 1 1 1 Cdc37 N terminal kinase binding Phage_GP20 PF06810.6 CCF43210.1 - 0.014 14.8 0.6 0.017 14.5 0.4 1.2 1 0 0 1 1 1 0 Phage minor structural protein GP20 Metallophos PF00149.23 CCF43211.1 - 0.0021 17.5 2.8 0.0067 15.8 1.9 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CCF43211.1 - 0.0038 17.0 0.0 0.012 15.4 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain MMtag PF10159.4 CCF43215.1 - 1.6e-28 98.5 9.8 1.6e-28 98.5 6.8 2.4 2 1 0 2 2 2 1 Kinase phosphorylation protein Ribosomal_60s PF00428.14 CCF43215.1 - 0.82 10.1 7.8 3.3 8.1 1.3 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Draxin PF15550.1 CCF43215.1 - 2.8 7.5 9.7 3.8 7.0 6.7 1.3 1 0 0 1 1 1 0 Draxin SRRM_C PF15230.1 CCF43215.1 - 3.4 7.8 28.0 0.33 11.0 13.7 2.3 2 0 0 2 2 2 0 Serine/arginine repetitive matrix protein C-terminus Med6 PF04934.9 CCF43216.1 - 3.9e-39 133.3 0.0 5.6e-39 132.8 0.0 1.2 1 0 0 1 1 1 1 MED6 mediator sub complex component p450 PF00067.17 CCF43218.1 - 6.2e-25 87.6 0.0 7.6e-25 87.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Abhydrolase_6 PF12697.2 CCF43219.1 - 2e-28 99.8 3.1 2.3e-28 99.6 2.1 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF43219.1 - 1.7e-17 63.5 0.0 2.6e-17 62.9 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF43219.1 - 0.00026 20.6 0.0 0.54 9.7 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold PGAP1 PF07819.8 CCF43219.1 - 0.0011 18.5 0.0 0.0021 17.7 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein UPF0227 PF05728.7 CCF43219.1 - 0.0067 16.1 0.0 0.08 12.6 0.0 2.1 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0227) DLH PF01738.13 CCF43219.1 - 0.03 13.6 0.0 0.29 10.3 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Thioesterase PF00975.15 CCF43219.1 - 0.062 13.5 0.0 0.21 11.7 0.0 1.8 2 1 0 2 2 2 0 Thioesterase domain HTH_16 PF12645.2 CCF43219.1 - 0.13 12.2 0.1 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain DUF3089 PF11288.3 CCF43219.1 - 0.13 11.3 0.0 0.24 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Sugar_tr PF00083.19 CCF43220.1 - 1.3e-86 290.9 13.5 1.5e-86 290.7 9.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF43220.1 - 1.2e-21 76.8 15.1 1.2e-21 76.8 10.5 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF1228 PF06779.9 CCF43220.1 - 1.5 8.9 8.3 0.11 12.5 0.6 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1228) Nucleocapsid-N PF11030.3 CCF43221.1 - 0.029 14.1 0.1 0.034 13.9 0.1 1.2 1 0 0 1 1 1 0 Nucleocapsid protein N OPT PF03169.10 CCF43222.1 - 6.6e-42 143.7 22.3 7.9e-42 143.5 15.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Ost4 PF10215.4 CCF43222.1 - 0.44 10.0 0.1 0.44 10.0 0.1 2.4 2 0 0 2 2 2 0 Oligosaccaryltransferase DUF4191 PF13829.1 CCF43222.1 - 6.1 5.8 5.9 2.4 7.2 2.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) oligo_HPY PF08352.7 CCF43224.1 - 0.016 15.5 0.1 0.023 15.0 0.0 1.5 1 1 0 1 1 1 0 Oligopeptide/dipeptide transporter, C-terminal region TB PF00683.12 CCF43225.1 - 0.0032 17.0 0.1 0.0046 16.4 0.1 1.3 1 0 0 1 1 1 1 TB domain Glyco_hydro_3_C PF01915.17 CCF43226.1 - 7.3e-36 123.7 0.1 9.9e-36 123.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 CCF43226.1 - 1.2e-27 95.6 0.1 2.1e-27 94.8 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain zf-H2C2 PF09337.5 CCF43227.1 - 7e-22 76.5 5.0 1.2e-21 75.8 3.4 1.4 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Acetyltransf_4 PF13420.1 CCF43227.1 - 0.00012 22.0 0.0 0.00022 21.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CCF43227.1 - 0.0046 16.9 0.0 0.01 15.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.1 CCF43227.1 - 0.0087 16.2 0.0 0.019 15.1 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Imm47 PF15586.1 CCF43227.1 - 0.2 11.5 0.0 0.37 10.6 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 47 adh_short_C2 PF13561.1 CCF43228.1 - 3.1e-34 118.7 0.1 3.7e-34 118.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF43228.1 - 5.8e-20 71.8 2.4 7.7e-20 71.4 1.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF43228.1 - 1e-06 28.5 0.7 1.6e-06 27.9 0.5 1.2 1 0 0 1 1 1 1 KR domain Dabb PF07876.7 CCF43229.1 - 1.6e-15 57.3 0.2 2.2e-15 56.8 0.2 1.2 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain DIE2_ALG10 PF04922.7 CCF43230.1 - 2.7e-15 56.3 0.9 3e-15 56.1 0.1 1.4 2 0 0 2 2 2 1 DIE2/ALG10 family PspC PF04024.7 CCF43230.1 - 0.91 9.0 3.9 0.61 9.5 0.1 2.0 2 0 0 2 2 2 0 PspC domain QCR10 PF09796.4 CCF43231.1 - 3.3e-25 87.5 0.2 4.6e-25 87.0 0.1 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) UCR_6-4kD PF08997.5 CCF43231.1 - 0.0073 15.9 0.8 0.039 13.6 0.3 2.3 1 1 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex, 6.4kD protein PASTA PF03793.14 CCF43231.1 - 0.026 14.1 0.0 0.053 13.1 0.0 1.5 1 0 0 1 1 1 0 PASTA domain Med4 PF10018.4 CCF43232.1 - 9.1e-24 83.8 0.4 1.2e-23 83.4 0.2 1.2 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 PspA_IM30 PF04012.7 CCF43232.1 - 0.0014 18.0 3.0 0.0019 17.6 2.1 1.1 1 0 0 1 1 1 1 PspA/IM30 family SQS_PSY PF00494.14 CCF43232.1 - 0.008 15.5 0.4 0.01 15.1 0.3 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase HECT PF00632.20 CCF43232.1 - 0.023 13.8 0.1 0.027 13.6 0.1 1.1 1 0 0 1 1 1 0 HECT-domain (ubiquitin-transferase) GATase_4 PF13230.1 CCF43232.1 - 0.084 11.5 0.1 0.1 11.2 0.0 1.1 1 0 0 1 1 1 0 Glutamine amidotransferases class-II IQ PF00612.22 CCF43233.1 - 0.0088 15.5 0.2 0.039 13.6 0.0 2.1 2 0 0 2 2 2 1 IQ calmodulin-binding motif Lipoprotein_5 PF01298.13 CCF43236.1 - 0.073 12.0 0.0 0.085 11.7 0.0 1.1 1 0 0 1 1 1 0 Transferrin binding protein-like solute binding protein DUF1772 PF08592.6 CCF43238.1 - 0.049 13.3 3.0 0.079 12.6 2.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) GMC_oxred_C PF05199.8 CCF43239.1 - 5.1e-11 43.0 0.0 7e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase Methyltransf_3 PF01596.12 CCF43240.1 - 3.1e-24 85.1 0.0 3.9e-24 84.8 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.1 CCF43240.1 - 5.5e-12 46.4 0.0 8.6e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF43240.1 - 1.3e-08 35.3 0.0 2.2e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF43240.1 - 5.2e-08 32.6 0.0 7.8e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF43240.1 - 6.5e-07 29.3 0.0 1.2e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF43240.1 - 0.00027 20.6 0.0 0.00033 20.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF43240.1 - 0.0017 18.7 0.0 0.0026 18.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF43240.1 - 0.0029 17.9 0.0 0.0044 17.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.5 CCF43240.1 - 0.0037 16.8 0.0 0.0051 16.3 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.10 CCF43240.1 - 0.0074 15.6 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 RrnaAD PF00398.15 CCF43240.1 - 0.099 11.6 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase MARVEL PF01284.18 CCF43241.1 - 1.4e-07 31.3 8.5 3.8e-07 30.0 5.9 1.6 1 1 0 1 1 1 1 Membrane-associating domain Cyt_c_ox_IV PF12270.3 CCF43241.1 - 0.1 12.3 0.2 0.1 12.3 0.1 2.9 1 1 1 3 3 3 0 Cytochrome c oxidase subunit IV dCMP_cyt_deam_1 PF00383.17 CCF43242.1 - 4.2e-11 42.4 2.6 3.5e-06 26.6 1.1 2.5 1 1 1 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region zf-CCHC PF00098.18 CCF43242.1 - 8.9e-05 22.2 0.2 0.00018 21.2 0.2 1.6 1 0 0 1 1 1 1 Zinc knuckle Glyco_hydro_3 PF00933.16 CCF43243.1 - 0.00019 20.5 0.0 0.00023 20.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Gal_mutarotas_2 PF13802.1 CCF43244.1 - 0.12 12.2 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Galactose mutarotase-like Aconitase PF00330.15 CCF43245.1 - 1.8e-145 485.0 0.0 1.5e-144 481.9 0.0 1.9 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 CCF43245.1 - 6.7e-05 23.0 0.0 0.00014 21.9 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.8 CCF43245.1 - 0.073 11.5 0.0 0.12 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Pam17 PF08566.5 CCF43246.1 - 0.14 11.8 0.1 0.36 10.4 0.0 1.6 2 0 0 2 2 2 0 Mitochondrial import protein Pam17 DUF3054 PF11255.3 CCF43246.1 - 0.2 11.4 6.2 0.14 12.0 2.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3054) Sugar_tr PF00083.19 CCF43247.1 - 2.1e-44 151.8 14.1 2.5e-44 151.6 9.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF43247.1 - 1.7e-06 27.0 16.4 2e-06 26.7 11.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily UAA PF08449.6 CCF43247.1 - 0.0046 15.9 0.3 0.0087 15.0 0.2 1.4 1 0 0 1 1 1 1 UAA transporter family Abhydrolase_5 PF12695.2 CCF43250.1 - 2.3e-21 76.0 0.0 3.4e-21 75.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF43250.1 - 5.3e-18 65.7 0.1 1.5e-16 60.9 0.1 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF43250.1 - 7.5e-06 25.6 0.0 0.0012 18.4 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold AXE1 PF05448.7 CCF43250.1 - 0.00014 20.4 0.0 0.036 12.5 0.0 2.7 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Abhydrolase_2 PF02230.11 CCF43250.1 - 0.00019 20.9 0.0 0.1 12.0 0.0 2.4 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase FSH1 PF03959.8 CCF43250.1 - 0.00043 19.7 0.0 0.0023 17.3 0.0 1.9 2 0 0 2 2 2 1 Serine hydrolase (FSH1) DUF818 PF05677.7 CCF43250.1 - 0.00066 18.5 0.0 0.00097 17.9 0.0 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Peptidase_S9 PF00326.16 CCF43250.1 - 0.0044 16.2 0.0 0.02 14.1 0.0 1.9 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.13 CCF43250.1 - 0.013 14.7 0.0 0.68 9.1 0.0 2.3 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_3 PF07859.8 CCF43250.1 - 0.014 14.9 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold BAAT_C PF08840.6 CCF43250.1 - 0.024 14.3 0.0 0.45 10.1 0.0 2.3 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Hydrolase_4 PF12146.3 CCF43250.1 - 0.035 13.9 0.1 0.12 12.1 0.0 1.9 2 0 0 2 2 2 0 Putative lysophospholipase p450 PF00067.17 CCF43251.1 - 0.00028 19.5 0.0 0.00032 19.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Nucleoside_tran PF01733.13 CCF43252.1 - 5.9e-38 130.7 3.5 5.9e-38 130.7 2.4 1.9 2 0 0 2 2 2 1 Nucleoside transporter MFS_1 PF07690.11 CCF43252.1 - 0.0017 17.1 6.8 0.0017 17.1 4.7 3.2 1 1 2 3 3 3 2 Major Facilitator Superfamily Glyco_transf_90 PF05686.7 CCF43253.1 - 1.2e-13 50.5 3.1 1.7e-11 43.4 1.1 2.9 2 1 0 2 2 2 2 Glycosyl transferase family 90 Paf1 PF03985.8 CCF43254.1 - 3e-49 167.9 0.0 4.4e-49 167.3 0.0 1.2 1 0 0 1 1 1 1 Paf1 ABC_tran PF00005.22 CCF43255.1 - 6.2e-36 123.7 0.0 2.3e-35 121.8 0.0 2.0 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.18 CCF43255.1 - 4.8e-22 78.6 9.3 6.2e-22 78.3 6.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 CCF43255.1 - 3.3e-07 29.7 0.8 0.00011 21.5 0.0 2.4 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF43255.1 - 1.6e-06 28.3 0.1 0.041 13.8 0.0 2.4 1 1 0 2 2 2 2 AAA domain AAA_22 PF13401.1 CCF43255.1 - 0.0003 20.9 0.4 0.002 18.2 0.3 2.1 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 CCF43255.1 - 0.00037 19.9 0.3 0.00094 18.6 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.1 CCF43255.1 - 0.0049 16.7 0.6 0.038 13.8 0.4 2.3 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_10 PF12846.2 CCF43255.1 - 0.0084 15.5 0.2 0.035 13.5 0.0 1.9 1 1 0 2 2 2 1 AAA-like domain FtsK_SpoIIIE PF01580.13 CCF43255.1 - 0.023 14.1 0.1 0.052 13.0 0.1 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF258 PF03193.11 CCF43255.1 - 0.035 13.3 1.1 0.053 12.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DUF87 PF01935.12 CCF43255.1 - 0.038 13.7 0.3 0.18 11.6 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_15 PF13175.1 CCF43255.1 - 0.05 12.6 0.1 0.25 10.3 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_16 PF13191.1 CCF43255.1 - 0.068 13.1 1.1 0.25 11.3 0.8 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.1 CCF43255.1 - 0.078 13.7 0.3 0.21 12.4 0.2 1.7 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.1 CCF43255.1 - 0.1 11.9 0.1 0.23 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain CoA_binding_3 PF13727.1 CCF43257.1 - 0.064 13.0 0.4 0.15 11.9 0.2 1.7 1 1 0 1 1 1 0 CoA-binding domain Pex24p PF06398.6 CCF43258.1 - 1e-42 146.2 9.4 1.4e-42 145.8 6.5 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF202 PF02656.10 CCF43259.1 - 0.0015 18.6 2.2 0.0045 17.1 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF347 PF03988.7 CCF43259.1 - 2.1 8.2 5.8 2.8 7.9 0.1 2.6 2 0 0 2 2 2 0 Repeat of Unknown Function (DUF347) ABC_trans_N PF14510.1 CCF43260.1 - 4.1e-20 71.6 0.2 1.1e-19 70.2 0.0 1.9 2 0 0 2 2 2 1 ABC-transporter extracellular N-terminal ABC_tran PF00005.22 CCF43260.1 - 5e-09 36.5 0.0 1.3e-08 35.1 0.0 1.7 2 0 0 2 2 2 1 ABC transporter AAA_33 PF13671.1 CCF43260.1 - 0.0027 17.5 0.0 0.0079 16.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CCF43260.1 - 0.02 14.8 0.0 0.047 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain T2SE PF00437.15 CCF43260.1 - 0.14 11.0 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein P16-Arc PF04699.9 CCF43262.1 - 2.7e-54 183.3 0.0 3.2e-54 183.0 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Methyltransf_23 PF13489.1 CCF43263.1 - 7.8e-10 38.6 0.0 1.6e-09 37.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF43263.1 - 3.4e-08 33.8 0.0 8.5e-08 32.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF43263.1 - 7e-06 26.4 0.0 1.3e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF43263.1 - 0.00065 19.3 0.0 0.0036 16.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF43263.1 - 0.036 14.6 0.0 0.42 11.2 0.0 2.5 2 1 0 2 2 2 0 Methyltransferase domain KH_1 PF00013.24 CCF43264.1 - 7.5e-37 124.7 11.5 2e-14 52.9 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 CCF43264.1 - 7.8e-30 101.9 11.4 3.4e-11 42.5 0.5 3.4 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 CCF43264.1 - 2.4e-09 36.6 7.9 0.0045 16.5 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.1 CCF43264.1 - 2e-08 33.7 1.8 0.075 12.6 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.1 CCF43264.1 - 0.00044 20.0 4.6 0.66 9.8 0.0 3.3 3 0 0 3 3 3 2 NusA-like KH domain dUTPase PF00692.14 CCF43264.1 - 0.013 14.9 0.2 1 8.8 0.0 3.0 3 0 0 3 3 3 0 dUTPase UAA PF08449.6 CCF43265.1 - 4.8e-71 239.1 12.4 1.8e-70 237.2 8.6 1.7 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 CCF43265.1 - 5.5e-07 29.6 28.5 0.00024 21.1 5.8 3.3 3 0 0 3 3 3 3 EamA-like transporter family Nuc_sug_transp PF04142.10 CCF43265.1 - 0.0014 17.7 5.2 0.075 12.1 0.4 2.3 2 0 0 2 2 2 2 Nucleotide-sugar transporter EmrE PF13536.1 CCF43265.1 - 0.0027 17.8 22.2 0.032 14.4 4.6 3.3 3 0 0 3 3 3 2 Multidrug resistance efflux transporter TPT PF03151.11 CCF43265.1 - 0.007 16.0 7.9 0.007 16.0 5.5 2.4 2 1 0 2 2 2 1 Triose-phosphate Transporter family Peptidase_U4 PF03419.8 CCF43265.1 - 0.65 9.0 7.5 0.27 10.2 2.5 2.0 2 0 0 2 2 2 0 Sporulation factor SpoIIGA DSPc PF00782.15 CCF43266.1 - 5.1e-24 84.3 0.1 5.3e-23 81.0 0.0 2.1 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 CCF43266.1 - 0.0073 15.6 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase LysM PF01476.15 CCF43267.1 - 2.7e-19 68.7 0.0 7.3e-09 35.3 0.0 2.2 2 0 0 2 2 2 2 LysM domain Yeast-kill-tox PF09207.6 CCF43267.1 - 0.086 13.2 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Yeast killer toxin PhyH PF05721.8 CCF43268.1 - 5.3e-10 39.6 0.0 7.9e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) SCP2 PF02036.12 CCF43268.1 - 0.00022 21.4 0.0 0.00038 20.6 0.0 1.4 1 0 0 1 1 1 1 SCP-2 sterol transfer family Lbh PF15317.1 CCF43268.1 - 0.12 12.6 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 Cardiac transcription factor regulator, Developmental protein zf-MYND PF01753.13 CCF43269.1 - 0.16 11.8 5.2 0.29 11.0 3.6 1.4 1 0 0 1 1 1 0 MYND finger Mpv17_PMP22 PF04117.7 CCF43270.1 - 3.3e-17 61.8 2.9 9e-17 60.4 2.1 1.7 2 0 0 2 2 2 1 Mpv17 / PMP22 family HMGL-like PF00682.14 CCF43271.1 - 1.5e-33 116.4 0.0 2.3e-33 115.8 0.0 1.2 1 0 0 1 1 1 1 HMGL-like TRAPP PF04051.11 CCF43272.1 - 3.6e-37 127.2 0.0 4.2e-37 127.0 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DUF4250 PF14056.1 CCF43272.1 - 0.021 14.5 0.1 0.045 13.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) PS-DH PF14765.1 CCF43273.1 - 4.6e-40 137.6 1.4 5.5e-40 137.3 0.4 1.5 2 0 0 2 2 2 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.16 CCF43273.1 - 1.5e-22 80.3 0.0 2.1e-22 79.8 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain Cript PF10235.4 CCF43275.1 - 2.7e-26 91.7 9.0 4.2e-26 91.1 6.2 1.3 1 0 0 1 1 1 1 Microtubule-associated protein CRIPT DUF2039 PF10217.4 CCF43275.1 - 0.011 15.7 9.9 0.011 15.7 6.8 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) Ribosomal_L32p PF01783.18 CCF43275.1 - 0.027 14.6 3.4 0.027 14.6 2.4 2.5 2 1 1 3 3 3 0 Ribosomal L32p protein family DZR PF12773.2 CCF43275.1 - 0.027 14.2 14.0 0.05 13.4 2.7 2.9 2 1 0 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.1 CCF43275.1 - 0.31 10.2 11.1 0.68 9.2 0.9 3.1 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 CCF43275.1 - 0.6 9.6 13.0 9.6 5.8 4.8 3.2 2 1 0 2 2 2 0 zinc-ribbon domain DUF1272 PF06906.6 CCF43275.1 - 1.6 8.6 7.5 0.26 11.1 2.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) zf-RING_5 PF14634.1 CCF43275.1 - 4.5 7.0 12.8 17 5.2 6.4 2.9 2 1 0 2 2 2 0 zinc-RING finger domain Zn_Tnp_IS91 PF14319.1 CCF43275.1 - 5.4 6.5 9.6 1.7 8.1 4.1 1.9 2 0 0 2 2 2 0 Transposase zinc-binding domain Abhydrolase_6 PF12697.2 CCF43276.1 - 1.4e-31 110.1 0.0 2.2e-31 109.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF43276.1 - 1.5e-18 67.2 0.0 4.4e-17 62.4 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF43276.1 - 2.1e-13 50.2 0.0 6.2e-13 48.7 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CCF43276.1 - 6.3e-05 22.7 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_2 PF02230.11 CCF43276.1 - 0.038 13.4 0.0 0.23 10.8 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Pinin_SDK_memA PF04696.8 CCF43277.1 - 1.6e-25 89.2 13.6 2.7e-25 88.4 9.4 1.4 1 0 0 1 1 1 1 pinin/SDK/memA/ protein conserved region PHF5 PF03660.9 CCF43278.1 - 1.6e-51 172.8 10.6 1.9e-51 172.6 7.3 1.0 1 0 0 1 1 1 1 PHF5-like protein DZR PF12773.2 CCF43278.1 - 1.1 9.1 15.8 19 5.1 10.1 2.8 1 1 0 1 1 1 0 Double zinc ribbon Prok-RING_1 PF14446.1 CCF43278.1 - 1.4 8.7 15.7 3 7.6 0.5 3.1 3 1 0 3 3 3 0 Prokaryotic RING finger family 1 PolC_DP2 PF03833.8 CCF43278.1 - 4 4.9 5.7 3.9 5.0 4.0 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 PHD PF00628.24 CCF43278.1 - 7.2 6.3 15.4 0.21 11.2 4.5 2.5 1 1 1 2 2 2 0 PHD-finger Pex26 PF07163.7 CCF43279.1 - 0.011 14.6 1.8 0.023 13.6 1.2 1.5 1 0 0 1 1 1 0 Pex26 protein Herpes_DNAp_acc PF04929.7 CCF43279.1 - 0.03 13.2 0.0 0.074 12.0 0.0 1.6 1 1 0 1 1 1 0 Herpes DNA replication accessory factor HAND PF09110.6 CCF43279.1 - 0.054 13.8 5.0 2 8.8 5.8 1.8 2 0 0 2 2 2 0 HAND DUF572 PF04502.8 CCF43279.1 - 0.084 12.0 14.1 0.17 11.0 9.8 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) SAPS PF04499.10 CCF43279.1 - 0.11 11.0 2.9 0.15 10.6 2.0 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CAF1 PF04857.15 CCF43280.1 - 2.3e-42 145.1 0.0 3.7e-42 144.4 0.0 1.3 1 1 0 1 1 1 1 CAF1 family ribonuclease Minor_capsid_3 PF12691.2 CCF43280.1 - 0.037 13.7 0.1 0.078 12.6 0.0 1.5 1 0 0 1 1 1 0 Minor capsid protein from bacteriophage PCP_red PF08369.5 CCF43280.1 - 0.065 13.1 0.1 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Proto-chlorophyllide reductase 57 kD subunit Sigma70_ner PF04546.8 CCF43280.1 - 0.92 9.0 3.9 0.29 10.7 0.3 1.9 2 0 0 2 2 2 0 Sigma-70, non-essential region Abhydrolase_6 PF12697.2 CCF43284.1 - 2.5e-13 50.4 0.1 3.9e-13 49.8 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF43284.1 - 4.2e-13 49.2 0.1 7.3e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF43284.1 - 4.2e-08 33.0 0.0 6.4e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.13 CCF43284.1 - 0.00048 19.6 0.2 0.0011 18.4 0.1 1.4 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.3 CCF43284.1 - 0.00082 19.1 0.2 0.0024 17.7 0.1 1.8 1 1 0 1 1 1 1 Putative lysophospholipase Abhydrolase_3 PF07859.8 CCF43284.1 - 0.00095 18.7 0.2 0.0016 18.0 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 CCF43284.1 - 0.026 13.9 0.2 0.2 11.0 0.1 2.0 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Lipase PF00151.14 CCF43284.1 - 0.18 11.0 0.0 0.25 10.5 0.0 1.2 1 0 0 1 1 1 0 Lipase Chitin_synth_2 PF03142.10 CCF43285.1 - 5.2e-156 520.1 2.8 6.8e-156 519.7 1.9 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.1 CCF43285.1 - 1.5e-18 67.2 1.6 2.8e-18 66.3 1.1 1.5 1 1 0 1 1 1 1 Glycosyl transferase family group 2 DEK_C PF08766.6 CCF43285.1 - 6.8e-15 54.5 0.3 3.4e-13 49.1 0.3 2.3 2 0 0 2 2 2 1 DEK C terminal domain Glyco_tranf_2_3 PF13641.1 CCF43285.1 - 5.6e-12 45.9 0.0 8.8e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 CCF43285.1 - 6.3e-07 28.8 0.0 4.4e-06 26.0 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 CCF43285.1 - 0.0058 16.3 0.0 0.015 14.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 DUF3357 PF11837.3 CCF43287.1 - 0.016 15.0 0.4 0.074 12.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3357) Herpes_US9 PF06072.6 CCF43287.1 - 1.7 8.5 3.3 2.9 7.7 2.3 1.3 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 Abhydrolase_3 PF07859.8 CCF43288.1 - 1.4e-11 44.4 0.0 3.5e-11 43.0 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold SGL PF08450.7 CCF43289.1 - 1.2e-24 87.0 0.0 2.8e-24 85.8 0.0 1.5 1 1 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Arylesterase PF01731.15 CCF43289.1 - 0.00016 21.5 0.0 0.00037 20.4 0.0 1.6 1 0 0 1 1 1 1 Arylesterase Str_synth PF03088.11 CCF43289.1 - 0.1 12.6 0.0 0.27 11.3 0.0 1.8 1 1 0 1 1 1 0 Strictosidine synthase NHL PF01436.16 CCF43289.1 - 0.87 9.6 3.0 1.4 8.9 0.0 3.0 4 0 0 4 4 4 0 NHL repeat Pkinase PF00069.20 CCF43290.1 - 3.8e-19 68.8 0.0 4.7e-19 68.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF43290.1 - 1.6e-09 37.2 0.0 1.9e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Phosphorylase PF00343.15 CCF43291.1 - 0 1078.6 0.1 0 1078.4 0.1 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase zf-C2H2_4 PF13894.1 CCF43292.1 - 0.0046 17.1 11.1 0.26 11.6 0.2 3.6 3 1 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF43292.1 - 0.35 11.2 7.1 1.8 9.0 0.1 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type MRP-L46 PF11788.3 CCF43294.1 - 2.6e-25 89.2 0.0 5.5e-25 88.1 0.0 1.6 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.23 CCF43294.1 - 4.1e-07 29.7 0.0 7.2e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain AMP-binding PF00501.23 CCF43296.1 - 3e-08 32.5 1.0 1.8e-07 29.8 0.7 2.2 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C_2 PF14535.1 CCF43296.1 - 0.022 14.8 0.3 0.043 13.8 0.2 1.5 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain CLASP_N PF12348.3 CCF43297.1 - 7.3e-07 28.7 0.0 9.3e-05 21.8 0.0 2.3 2 0 0 2 2 2 1 CLASP N terminal HEAT_2 PF13646.1 CCF43297.1 - 5.9e-06 26.4 1.7 0.11 12.7 0.2 3.4 3 0 0 3 3 3 2 HEAT repeats HEAT PF02985.17 CCF43297.1 - 6e-06 25.9 1.9 0.55 10.4 0.1 5.0 5 0 0 5 5 5 2 HEAT repeat APG6 PF04111.7 CCF43297.1 - 0.0013 17.8 5.4 0.0025 16.9 3.7 1.3 1 0 0 1 1 1 1 Autophagy protein Apg6 HemX PF04375.9 CCF43297.1 - 0.002 16.7 0.1 0.0042 15.7 0.1 1.4 1 0 0 1 1 1 1 HemX DUF1675 PF07897.6 CCF43297.1 - 0.0045 16.8 3.5 0.0045 16.8 2.4 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1675) MAP65_ASE1 PF03999.7 CCF43297.1 - 0.0086 14.7 4.0 0.017 13.7 2.8 1.4 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) Adaptin_N PF01602.15 CCF43297.1 - 0.01 14.1 0.1 1.5 7.0 0.0 2.9 2 1 1 3 3 3 0 Adaptin N terminal region HEAT_EZ PF13513.1 CCF43297.1 - 0.2 12.1 3.0 4.2 7.9 0.4 3.8 3 1 1 4 4 3 0 HEAT-like repeat TPR_MLP1_2 PF07926.7 CCF43297.1 - 0.24 11.1 10.7 0.14 11.8 5.2 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein CorA PF01544.13 CCF43297.1 - 0.86 8.5 5.8 1.6 7.7 4.0 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF972 PF06156.8 CCF43297.1 - 0.95 9.8 5.6 13 6.1 3.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Rab5-bind PF09311.6 CCF43297.1 - 1.8 8.4 12.4 2.8 7.8 7.0 2.2 2 0 0 2 2 2 0 Rabaptin-like protein ADIP PF11559.3 CCF43297.1 - 2.5 7.9 12.6 9.8 6.0 8.7 2.0 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding Seryl_tRNA_N PF02403.17 CCF43297.1 - 6.9 6.7 9.8 9.8 6.2 3.4 3.4 3 1 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain IncA PF04156.9 CCF43297.1 - 7.4 6.1 10.3 16 5.0 7.2 1.5 1 0 0 1 1 1 0 IncA protein HALZ PF02183.13 CCF43297.1 - 9 6.1 7.1 24 4.7 1.2 2.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper KH_1 PF00013.24 CCF43298.1 - 9.7e-40 134.0 5.9 1.3e-16 59.9 0.6 3.3 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 CCF43298.1 - 4.7e-31 105.9 12.7 2.5e-11 42.9 2.8 3.4 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 CCF43298.1 - 1.2e-12 47.1 3.9 0.0063 16.0 0.0 3.2 3 0 0 3 3 3 3 KH domain KH_4 PF13083.1 CCF43298.1 - 1.7e-05 24.3 1.0 0.59 9.8 0.0 3.3 3 0 0 3 3 3 2 KH domain KH_5 PF13184.1 CCF43298.1 - 0.0072 16.1 6.6 0.76 9.6 0.1 3.2 3 0 0 3 3 3 2 NusA-like KH domain adh_short PF00106.20 CCF43299.1 - 5.6e-14 52.3 0.0 1.1e-13 51.4 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase Glyco_hydro_3 PF00933.16 CCF43302.1 - 4.1e-61 206.5 0.0 1.3e-58 198.3 0.0 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 3 N terminal domain PPR_2 PF13041.1 CCF43304.1 - 2.2e-18 65.9 0.8 4.3e-05 23.3 0.0 5.8 5 1 1 6 6 6 4 PPR repeat family PPR_3 PF13812.1 CCF43304.1 - 5.5e-11 41.8 7.7 2.1e-05 24.4 0.0 7.4 7 0 0 7 7 7 1 Pentatricopeptide repeat domain PPR PF01535.15 CCF43304.1 - 7.1e-11 41.3 7.3 0.0025 17.6 0.0 7.0 8 0 0 8 8 8 3 PPR repeat RPM2 PF08579.6 CCF43304.1 - 5.9e-05 23.1 0.0 0.00045 20.3 0.0 2.4 2 1 0 2 2 2 1 Mitochondrial ribonuclease P subunit (RPM2) ATP13 PF12921.2 CCF43304.1 - 0.0086 15.4 0.2 0.065 12.5 0.1 2.2 1 1 1 2 2 2 1 Mitochondrial ATPase expression TPR_14 PF13428.1 CCF43304.1 - 0.1 13.2 16.9 17 6.4 0.0 7.5 9 1 1 10 10 10 0 Tetratricopeptide repeat PPR_1 PF12854.2 CCF43304.1 - 0.15 11.5 6.9 6.2 6.4 0.0 4.5 6 0 0 6 6 6 0 PPR repeat TALPID3 PF15324.1 CCF43305.1 - 0.4 7.9 8.0 0.47 7.7 5.5 1.0 1 0 0 1 1 1 0 Hedgehog signalling target AF-4 PF05110.8 CCF43305.1 - 2.7 5.7 12.3 3.5 5.3 8.5 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein HsbA PF12296.3 CCF43306.1 - 0.016 15.0 0.3 0.029 14.2 0.2 1.4 1 0 0 1 1 1 0 Hydrophobic surface binding protein A malic PF00390.14 CCF43308.1 - 2.8e-71 238.8 0.0 4.4e-71 238.2 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Malic_M PF03949.10 CCF43308.1 - 1.5e-56 191.7 0.0 2.3e-56 191.2 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain GMC_oxred_N PF00732.14 CCF43309.1 - 9.9e-14 51.1 0.0 1.9e-13 50.2 0.0 1.5 1 1 0 1 1 1 1 GMC oxidoreductase HHH PF00633.18 CCF43309.1 - 0.032 13.9 0.1 2 8.3 0.0 2.5 2 0 0 2 2 2 0 Helix-hairpin-helix motif Pyr_redox_3 PF13738.1 CCF43310.1 - 0.035 14.1 0.0 0.043 13.8 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF43310.1 - 0.053 13.5 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain p450 PF00067.17 CCF43312.1 - 4.1e-24 84.9 0.0 3e-11 42.5 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 MFS_1 PF07690.11 CCF43313.1 - 2.6e-08 32.9 27.0 6.6e-07 28.3 8.3 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Aldolase_II PF00596.16 CCF43313.1 - 0.088 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Class II Aldolase and Adducin N-terminal domain TMEMspv1-c74-12 PF11044.3 CCF43313.1 - 0.28 10.7 0.1 0.28 10.7 0.1 2.7 4 0 0 4 4 4 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Zn_clus PF00172.13 CCF43314.1 - 0.1 12.5 7.7 0.24 11.3 5.3 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain PAT1 PF09770.4 CCF43314.1 - 0.98 7.5 25.8 2.3 6.3 17.9 1.6 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 zf-C2H2_6 PF13912.1 CCF43314.1 - 3.9 7.5 5.2 1.1 9.2 0.3 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger Sec5 PF15469.1 CCF43315.1 - 7e-37 126.9 0.0 1e-35 123.1 0.0 2.6 2 1 0 2 2 2 1 Exocyst complex component Sec5 Vps51 PF08700.6 CCF43315.1 - 0.00016 21.3 2.4 0.00027 20.6 0.1 2.5 2 0 0 2 2 2 1 Vps51/Vps67 Iso_dh PF00180.15 CCF43316.1 - 6.5e-99 331.1 0.0 7.7e-99 330.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase GTP_EFTU PF00009.22 CCF43319.1 - 6.1e-48 162.7 0.0 9.7e-48 162.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.7 CCF43319.1 - 1.4e-38 131.0 4.2 2.5e-38 130.2 2.9 1.4 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.19 CCF43319.1 - 4.3e-17 61.7 0.0 7.8e-17 60.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 CCF43319.1 - 4e-05 23.3 0.0 0.00011 21.9 0.0 1.8 1 1 0 1 1 1 1 Elongation Factor G, domain II Ras PF00071.17 CCF43319.1 - 4.5e-05 22.8 0.0 0.00013 21.3 0.0 1.7 2 0 0 2 2 2 1 Ras family MMR_HSR1 PF01926.18 CCF43319.1 - 5.9e-05 23.0 0.0 0.00017 21.5 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 CCF43319.1 - 0.0029 17.6 0.0 0.0066 16.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 SRPRB PF09439.5 CCF43319.1 - 0.05 12.8 0.0 0.13 11.4 0.0 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Miro PF08477.8 CCF43319.1 - 0.083 13.3 0.0 0.19 12.2 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein His_Phos_1 PF00300.17 CCF43320.1 - 1.8e-07 31.3 0.0 2.4e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) CTNNBL PF08216.6 CCF43321.1 - 9.8e-37 124.8 0.3 5e-36 122.5 0.0 2.4 3 0 0 3 3 3 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.18 CCF43321.1 - 0.00047 19.8 0.2 0.46 10.3 0.0 4.3 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Clathrin PF00637.15 CCF43321.1 - 0.0063 16.1 0.1 0.72 9.4 0.0 3.0 1 1 2 3 3 3 1 Region in Clathrin and VPS HEAT_2 PF13646.1 CCF43321.1 - 0.025 14.8 4.3 0.27 11.5 0.1 3.6 2 1 2 4 4 4 0 HEAT repeats DUF1911 PF08929.5 CCF43321.1 - 0.035 14.8 1.0 0.33 11.6 0.2 2.7 3 1 0 3 3 3 0 Domain of unknown function (DUF1911) V-ATPase_G PF03179.10 CCF43322.1 - 4.9e-33 113.5 16.9 5.5e-33 113.3 11.7 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit ATP-synt_B PF00430.13 CCF43322.1 - 0.0015 18.3 8.3 0.0015 18.3 5.7 2.0 1 1 1 2 2 2 1 ATP synthase B/B' CF(0) DUF3552 PF12072.3 CCF43322.1 - 0.012 14.8 10.8 0.012 14.8 7.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) Nop25 PF09805.4 CCF43322.1 - 0.043 13.9 15.1 0.054 13.5 10.5 1.1 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) YusW PF14039.1 CCF43322.1 - 0.11 12.7 4.2 0.18 12.1 2.9 1.3 1 0 0 1 1 1 0 YusW-like protein SAPS PF04499.10 CCF43322.1 - 0.42 9.1 7.1 0.46 9.0 4.9 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RRF PF01765.14 CCF43322.1 - 0.68 9.3 13.2 0.91 8.9 9.2 1.2 1 0 0 1 1 1 0 Ribosome recycling factor Vfa1 PF08432.5 CCF43322.1 - 1 9.3 13.7 1.1 9.2 9.5 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 HAUS6_N PF14661.1 CCF43322.1 - 2.2 7.5 8.4 2.2 7.5 5.2 1.4 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus vATP-synt_E PF01991.13 CCF43322.1 - 3 7.0 20.0 2.5 7.3 7.7 2.1 1 1 0 2 2 2 0 ATP synthase (E/31 kDa) subunit DUF2151 PF10221.4 CCF43322.1 - 5.5 5.0 8.3 6.5 4.7 5.8 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator OmpH PF03938.9 CCF43322.1 - 6.9 6.5 11.2 9.2 6.1 7.8 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF883 PF05957.8 CCF43322.1 - 8.9 6.7 10.3 35 4.8 4.1 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Brr6_like_C_C PF10104.4 CCF43323.1 - 0.14 11.6 0.0 0.15 11.5 0.0 1.0 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain RNA_pol_Rpb2_6 PF00562.23 CCF43324.1 - 2.6e-126 421.4 0.1 6.6e-126 420.1 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 CCF43324.1 - 5.2e-57 192.0 0.0 9.5e-57 191.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 CCF43324.1 - 1.8e-47 161.2 0.0 3.5e-47 160.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.15 CCF43324.1 - 9.1e-31 105.9 0.0 2.1e-30 104.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_5 PF04567.12 CCF43324.1 - 1.1e-23 82.8 0.7 3.1e-23 81.4 0.5 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_3 PF04565.11 CCF43324.1 - 8.4e-23 79.9 0.0 1.9e-22 78.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.8 CCF43324.1 - 2.5e-18 65.6 1.4 6.6e-18 64.2 0.9 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 Glyco_hydro_45 PF02015.11 CCF43325.1 - 1.4e-39 136.2 1.2 2.1e-39 135.6 0.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 IDO PF01231.13 CCF43326.1 - 5.9e-169 561.9 0.0 6.9e-169 561.7 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase ASF1_hist_chap PF04729.8 CCF43327.1 - 9.9e-67 223.3 0.0 1.3e-66 222.9 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone KR PF08659.5 CCF43328.1 - 7.6e-60 201.6 1.2 8.8e-60 201.4 0.1 1.7 2 0 0 2 2 2 1 KR domain adh_short PF00106.20 CCF43328.1 - 1.5e-46 158.3 1.1 1.1e-45 155.4 0.1 2.3 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N PF00107.21 CCF43328.1 - 3.4e-19 68.6 0.0 7.6e-19 67.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF43328.1 - 1.8e-10 41.8 0.0 1.5e-09 38.8 0.0 2.5 3 0 0 3 3 3 1 Zinc-binding dehydrogenase PP-binding PF00550.20 CCF43328.1 - 2.7e-05 24.3 0.0 6.4e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_N PF08240.7 CCF43328.1 - 0.0029 17.3 0.1 0.006 16.3 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ThiF PF00899.16 CCF43328.1 - 0.018 14.8 0.1 0.043 13.6 0.1 1.7 1 0 0 1 1 1 0 ThiF family NAD_binding_10 PF13460.1 CCF43328.1 - 0.028 14.4 5.4 1.5 8.7 0.2 2.9 2 1 0 2 2 2 0 NADH(P)-binding YjeF_N PF03853.10 CCF43328.1 - 0.11 12.1 0.5 10 5.6 0.1 2.4 2 0 0 2 2 2 0 YjeF-related protein N-terminus PEX11 PF05648.9 CCF43331.1 - 9.4e-75 250.6 0.5 1.1e-74 250.5 0.3 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) FBPase PF00316.15 CCF43332.1 - 8.4e-122 406.0 0.0 9.6e-122 405.8 0.0 1.0 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase DUF1295 PF06966.7 CCF43333.1 - 3.8e-40 137.6 0.8 1.7e-31 109.3 0.2 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1295) Steroid_dh PF02544.11 CCF43333.1 - 0.001 18.8 0.0 0.0024 17.6 0.0 1.6 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.8 CCF43333.1 - 0.016 15.3 0.0 0.085 12.9 0.0 2.2 1 1 1 2 2 2 0 Phospholipid methyltransferase ERG4_ERG24 PF01222.12 CCF43333.1 - 0.11 11.0 0.0 0.16 10.4 0.0 1.3 1 0 0 1 1 1 0 Ergosterol biosynthesis ERG4/ERG24 family Homoserine_dh PF00742.14 CCF43334.1 - 1.3e-51 174.7 0.0 1.7e-51 174.4 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.11 CCF43334.1 - 2e-17 63.6 0.0 3.3e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain AAA_17 PF13207.1 CCF43334.1 - 0.064 14.0 0.0 0.12 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 CCF43334.1 - 0.12 11.7 0.2 0.94 8.8 0.2 2.2 1 1 0 1 1 1 0 AAA domain CIA30 PF08547.7 CCF43335.1 - 1.8e-37 128.6 0.0 2.3e-37 128.2 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) p450 PF00067.17 CCF43337.1 - 5.1e-17 61.5 0.0 2.5e-09 36.1 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 Barttin PF15462.1 CCF43338.1 - 0.028 14.0 0.1 0.033 13.8 0.1 1.1 1 0 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) Sugar_tr PF00083.19 CCF43341.1 - 2.1e-06 26.6 3.4 3.3e-06 25.9 2.3 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter EST1_DNA_bind PF10373.4 CCF43343.1 - 1.1e-35 123.1 0.1 1.3e-35 122.9 0.1 1.0 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.4 CCF43343.1 - 6.5e-05 22.9 1.1 0.00016 21.6 0.1 2.0 3 0 0 3 3 3 1 Telomerase activating protein Est1 TPR_11 PF13414.1 CCF43343.1 - 0.00088 18.8 0.2 0.0035 16.9 0.0 1.9 2 0 0 2 2 2 1 TPR repeat TPR_12 PF13424.1 CCF43343.1 - 0.082 12.8 1.1 0.16 11.9 0.1 1.9 2 1 0 2 2 2 0 Tetratricopeptide repeat p450 PF00067.17 CCF43344.1 - 7.2e-47 159.9 0.0 9.7e-47 159.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Cerato-platanin PF07249.7 CCF43345.1 - 0.091 12.7 0.1 0.28 11.1 0.0 1.7 2 0 0 2 2 2 0 Cerato-platanin FA_desaturase PF00487.19 CCF43346.1 - 0.0031 16.9 1.4 0.0043 16.5 1.0 1.3 1 0 0 1 1 1 1 Fatty acid desaturase BNR_assoc_N PF14873.1 CCF43346.1 - 0.043 13.5 0.0 0.064 13.0 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain of BNR-repeat neuraminidase DUF4366 PF14283.1 CCF43348.1 - 0.024 14.0 0.0 0.033 13.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Mito_fiss_reg PF05308.6 CCF43348.1 - 0.52 9.6 4.1 0.061 12.6 0.3 1.4 2 0 0 2 2 2 0 Mitochondrial fission regulator CAP_N PF01213.14 CCF43348.1 - 2.3 7.4 4.2 0.71 9.0 0.9 1.6 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Dfp1_Him1_M PF08630.5 CCF43349.1 - 1.9e-35 121.3 0.0 4.5e-35 120.1 0.0 1.7 1 0 0 1 1 1 1 Dfp1/Him1, central region zf-DBF PF07535.7 CCF43349.1 - 2.1e-23 81.7 0.4 3.8e-23 80.8 0.3 1.4 1 0 0 1 1 1 1 DBF zinc finger PTCB-BRCT PF12738.2 CCF43349.1 - 0.018 14.9 0.0 0.047 13.5 0.0 1.8 1 0 0 1 1 1 0 twin BRCT domain BRCT PF00533.21 CCF43349.1 - 0.11 12.6 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain CopD PF05425.8 CCF43350.1 - 0.0046 17.1 0.1 0.0073 16.5 0.1 1.3 1 0 0 1 1 1 1 Copper resistance protein D Pyridoxal_deC PF00282.14 CCF43351.1 - 3.8e-31 107.8 0.0 4.6e-31 107.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.16 CCF43351.1 - 8e-06 25.1 0.0 9.3e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 CCF43351.1 - 0.0011 18.0 0.0 0.0018 17.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 CCF43351.1 - 0.0077 15.0 0.0 0.014 14.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V B5 PF03484.10 CCF43351.1 - 0.14 12.0 0.1 0.32 10.8 0.0 1.6 1 0 0 1 1 1 0 tRNA synthetase B5 domain ArfGap PF01412.13 CCF43352.1 - 1e-40 138.1 0.3 2.2e-40 137.0 0.2 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf UBA PF00627.26 CCF43352.1 - 0.11 12.3 0.0 0.26 11.1 0.0 1.7 1 0 0 1 1 1 0 UBA/TS-N domain Glyco_hydro_76 PF03663.9 CCF43353.1 - 6.3e-148 493.0 16.7 8.2e-148 492.7 11.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Abp2 PF09441.5 CCF43355.1 - 4.8e-87 290.3 0.0 7.5e-87 289.7 0.0 1.3 1 0 0 1 1 1 1 ARS binding protein 2 Fungal_trans PF04082.13 CCF43356.1 - 7.2e-15 54.5 0.3 1.5e-14 53.5 0.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain UQ_con PF00179.21 CCF43357.1 - 1.6e-43 147.4 0.0 1.8e-43 147.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CCF43357.1 - 0.0029 17.3 0.0 0.0038 16.9 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 CCF43357.1 - 0.017 15.0 0.0 0.024 14.5 0.0 1.6 1 1 0 1 1 1 0 RWD domain UEV PF05743.8 CCF43357.1 - 0.034 13.8 0.0 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 UEV domain RabGAP-TBC PF00566.13 CCF43358.1 - 3.2e-35 121.5 0.1 3.3e-34 118.2 0.0 2.0 1 1 0 1 1 1 1 Rab-GTPase-TBC domain YfbU PF03887.9 CCF43358.1 - 0.058 12.9 0.0 0.096 12.2 0.0 1.3 1 0 0 1 1 1 0 YfbU domain Copper-fist PF00649.13 CCF43359.1 - 2.3e-22 77.8 1.6 2.3e-22 77.8 1.1 4.4 1 1 3 4 4 4 2 Copper fist DNA binding domain ECH PF00378.15 CCF43360.1 - 3.4e-23 82.0 0.0 3.5e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Sugar_tr PF00083.19 CCF43361.1 - 8.1e-105 350.9 22.7 9.2e-105 350.8 15.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF43361.1 - 6.7e-28 97.4 61.2 2.4e-23 82.4 20.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.15 CCF43361.1 - 0.00065 17.8 0.6 0.0012 16.9 0.4 1.5 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.8 CCF43361.1 - 0.44 8.6 9.6 0.36 8.9 0.8 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector EF-hand_1 PF00036.27 CCF43362.1 - 7.7e-38 124.9 14.3 1.4e-09 36.5 0.0 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 CCF43362.1 - 2.2e-33 114.2 5.8 1.7e-18 66.5 0.2 2.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 CCF43362.1 - 2.7e-30 101.4 8.5 1e-08 34.3 0.0 4.1 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 CCF43362.1 - 6.6e-29 99.2 11.6 3.2e-13 49.0 0.2 3.8 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 CCF43362.1 - 2.9e-25 86.4 12.6 8.1e-08 31.2 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.1 CCF43362.1 - 2.8e-16 59.1 0.1 9.2e-08 31.8 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 CCF43362.1 - 3.3e-09 36.4 1.5 0.0017 18.0 0.2 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 CCF43362.1 - 1.3e-05 25.1 0.0 0.069 13.1 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.8 CCF43362.1 - 0.00016 21.3 0.2 0.27 10.9 0.0 2.4 1 1 2 3 3 3 2 Tellurite resistance protein TerB EFhand_Ca_insen PF08726.5 CCF43362.1 - 0.00041 20.2 0.1 0.0057 16.5 0.0 2.2 2 0 0 2 2 2 1 Ca2+ insensitive EF hand UPF0154 PF03672.8 CCF43362.1 - 0.00095 18.7 0.0 0.27 10.8 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0154) Toprim_2 PF13155.1 CCF43362.1 - 0.0012 19.1 0.8 0.24 11.7 0.1 2.5 1 1 0 2 2 2 1 Toprim-like Toprim_4 PF13662.1 CCF43362.1 - 0.0088 16.0 0.5 0.62 10.1 0.0 2.7 2 1 0 2 2 2 1 Toprim domain Tenui_NCP PF04876.7 CCF43362.1 - 0.012 15.1 0.3 0.24 10.9 0.0 2.2 1 1 0 2 2 2 0 Tenuivirus major non-capsid protein GTPase_Cys_C PF12631.2 CCF43362.1 - 0.031 14.6 0.1 0.31 11.4 0.0 2.2 2 0 0 2 2 2 0 Catalytic cysteine-containing C-terminus of GTPase, MnmE Caleosin PF05042.8 CCF43362.1 - 0.072 12.6 0.0 6.6 6.2 0.0 2.4 2 1 0 2 2 2 0 Caleosin related protein BRE1 PF08647.6 CCF43365.1 - 1.7e-21 76.0 10.3 1.7e-21 76.0 7.1 6.2 5 1 1 6 6 5 1 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.1 CCF43365.1 - 2.7e-08 33.3 7.7 4.3e-08 32.7 5.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF43365.1 - 1.2e-07 31.2 10.7 2.1e-07 30.5 7.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CCF43365.1 - 2.5e-07 30.6 10.1 4.1e-07 29.9 7.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF43365.1 - 1.1e-05 25.0 10.7 1.8e-05 24.3 7.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 CCF43365.1 - 2.7e-05 23.8 8.8 4.5e-05 23.1 6.1 1.4 1 0 0 1 1 1 1 Ring finger domain DivIC PF04977.10 CCF43365.1 - 0.00036 19.9 1.7 0.00036 19.9 1.2 10.1 7 3 4 11 11 11 2 Septum formation initiator zf-RING_UBOX PF13445.1 CCF43365.1 - 0.00095 18.8 6.0 0.0026 17.4 4.2 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Reo_sigmaC PF04582.7 CCF43365.1 - 0.0051 16.0 18.2 0.15 11.1 2.2 4.2 3 2 2 5 5 5 2 Reovirus sigma C capsid protein zf-RING_6 PF14835.1 CCF43365.1 - 0.0078 15.9 2.7 0.016 14.9 1.9 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein TPR_MLP1_2 PF07926.7 CCF43365.1 - 0.008 15.9 12.9 0.008 15.9 8.9 6.2 3 2 3 6 6 6 2 TPR/MLP1/MLP2-like protein Phage_GP20 PF06810.6 CCF43365.1 - 0.0081 15.6 9.5 0.0081 15.6 6.6 7.8 3 2 3 8 8 8 1 Phage minor structural protein GP20 zf-C3HC4_4 PF15227.1 CCF43365.1 - 0.014 15.2 7.1 0.027 14.3 4.9 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.1 CCF43365.1 - 0.014 14.9 3.6 0.026 14.0 2.5 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DUF1664 PF07889.7 CCF43365.1 - 0.019 14.7 1.8 0.019 14.7 1.3 6.3 5 2 2 7 7 7 0 Protein of unknown function (DUF1664) zf-RING_4 PF14570.1 CCF43365.1 - 0.023 14.2 7.5 0.064 12.8 5.2 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain TerY-C PF15616.1 CCF43365.1 - 0.23 11.3 9.0 0.085 12.7 1.1 2.9 3 0 0 3 3 3 0 TerY-C metal binding domain DUF1272 PF06906.6 CCF43365.1 - 1.1 9.2 6.3 2.8 7.8 4.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-rbx1 PF12678.2 CCF43365.1 - 1.1 9.4 8.0 3.3 7.8 5.5 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger FYVE PF01363.16 CCF43365.1 - 6.5 6.7 11.6 61 3.6 8.0 2.3 1 1 1 2 2 2 0 FYVE zinc finger DUF2721 PF11026.3 CCF43365.1 - 8.3 6.0 5.3 54 3.4 0.2 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) DUF1183 PF06682.7 CCF43366.1 - 1.5e-89 300.7 7.3 2.2e-89 300.2 5.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1183) Fic PF02661.13 CCF43367.1 - 7.1e-14 52.2 0.0 2.6e-13 50.4 0.0 2.0 2 1 0 2 2 2 1 Fic/DOC family ABC_membrane PF00664.18 CCF43369.1 - 2.2e-18 66.6 9.4 3.2e-15 56.3 0.5 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region Actin PF00022.14 CCF43370.1 - 5.3e-23 81.0 0.0 2.2e-13 49.4 0.0 2.2 2 0 0 2 2 2 2 Actin MreB_Mbl PF06723.8 CCF43370.1 - 0.0049 15.5 0.0 0.016 13.7 0.0 1.7 2 0 0 2 2 2 1 MreB/Mbl protein PMD PF10536.4 CCF43371.1 - 0.048 12.6 0.0 0.057 12.4 0.0 1.1 1 0 0 1 1 1 0 Plant mobile domain RFamide_26RFa PF11109.3 CCF43371.1 - 0.091 12.6 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Orexigenic neuropeptide Qrfp/P518 Helicase_C PF00271.26 CCF43372.1 - 6.5e-10 38.7 0.0 1.4e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 CCF43372.1 - 0.056 12.2 0.0 0.081 11.7 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain ADC PF06314.6 CCF43374.1 - 0.00066 19.1 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) MFS_1 PF07690.11 CCF43375.1 - 4.4e-31 107.8 7.3 5.6e-31 107.5 5.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF43375.1 - 6.5e-09 34.8 3.9 7.9e-09 34.5 2.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Sensor PF13796.1 CCF43375.1 - 0.00033 20.3 3.9 0.00069 19.2 0.0 2.4 1 1 1 2 2 2 1 Putative sensor Kinesin PF00225.18 CCF43376.1 - 1.7e-51 174.9 0.0 2.4e-51 174.4 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain PAPS_reduct PF01507.14 CCF43377.1 - 1.5e-06 28.1 0.1 2e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family PEN-2 PF10251.4 CCF43378.1 - 0.022 15.0 0.4 2.1 8.5 0.0 3.0 3 0 0 3 3 3 0 Presenilin enhancer-2 subunit of gamma secretase Mito_carr PF00153.22 CCF43379.1 - 5.8e-18 64.3 0.4 6.8e-18 64.1 0.3 1.1 1 0 0 1 1 1 1 Mitochondrial carrier protein MARVEL PF01284.18 CCF43380.1 - 1.8e-05 24.5 25.4 6.7e-05 22.7 17.6 1.8 1 1 0 1 1 1 1 Membrane-associating domain DUF3551 PF12071.3 CCF43380.1 - 0.15 11.5 3.4 0.27 10.8 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3551) COPI_assoc PF08507.5 CCF43380.1 - 7 6.3 17.8 3.3 7.4 3.9 2.1 1 1 1 2 2 2 0 COPI associated protein Astacin PF01400.19 CCF43382.1 - 4.1e-32 111.1 0.0 4.4e-31 107.7 0.0 2.2 1 1 0 1 1 1 1 Astacin (Peptidase family M12A) zf-C4 PF00105.13 CCF43382.1 - 0.03 14.5 1.0 5 7.4 0.4 2.5 2 0 0 2 2 2 0 Zinc finger, C4 type (two domains) AMP-binding PF00501.23 CCF43383.1 - 1.3e-175 583.7 0.0 2.5e-87 292.9 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme NAD_binding_4 PF07993.7 CCF43383.1 - 6.5e-43 146.4 0.0 1e-42 145.7 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Condensation PF00668.15 CCF43383.1 - 2.3e-41 141.6 0.0 3.9e-41 140.8 0.0 1.4 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.20 CCF43383.1 - 1.1e-15 57.6 0.3 3.1e-09 36.9 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site Epimerase PF01370.16 CCF43383.1 - 1.8e-08 34.1 0.0 4.4e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.1 CCF43383.1 - 1e-06 29.6 0.0 0.016 16.1 0.0 3.6 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.14 CCF43383.1 - 0.0006 18.6 0.0 0.003 16.3 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 CCF43383.1 - 0.0024 17.8 0.1 0.008 16.1 0.0 1.9 2 0 0 2 2 2 1 NADH(P)-binding adh_short PF00106.20 CCF43383.1 - 0.006 16.5 0.1 0.027 14.3 0.0 2.1 1 0 0 1 1 1 1 short chain dehydrogenase Semialdhyde_dh PF01118.19 CCF43383.1 - 0.017 15.3 0.0 0.047 13.9 0.0 1.8 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Amidase PF01425.16 CCF43384.1 - 1.4e-75 254.8 1.9 1.8e-75 254.5 1.3 1.0 1 0 0 1 1 1 1 Amidase Glyoxal_oxid_N PF07250.6 CCF43386.1 - 5.8e-25 87.7 0.0 1.7e-23 82.9 0.0 2.7 3 0 0 3 3 3 1 Glyoxal oxidase N-terminus DUF1929 PF09118.6 CCF43386.1 - 1.2e-20 73.4 0.0 2.1e-20 72.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) WSC PF01822.14 CCF43386.1 - 2e-14 53.2 3.7 3.3e-14 52.5 2.5 1.4 1 0 0 1 1 1 1 WSC domain Macro_2 PF14519.1 CCF43386.1 - 0.071 12.2 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Macro-like domain Kelch_2 PF07646.10 CCF43386.1 - 0.096 12.4 0.4 3.2 7.6 0.1 3.2 2 1 1 3 3 3 0 Kelch motif Kelch_6 PF13964.1 CCF43386.1 - 1.5 9.0 4.7 3.2 8.0 0.0 3.9 6 0 0 6 6 6 0 Kelch motif DUF4414 PF14377.1 CCF43387.1 - 0.039 13.8 0.0 0.066 13.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4414) Methyltransf_16 PF10294.4 CCF43391.1 - 9e-14 51.3 0.0 3.4e-13 49.4 0.0 1.7 1 1 0 1 1 1 1 Putative methyltransferase PrmA PF06325.8 CCF43391.1 - 0.0037 16.4 0.1 0.005 16.0 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.2 CCF43391.1 - 0.019 15.5 0.0 0.029 14.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 CCF43391.1 - 0.084 12.5 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain GidB PF02527.10 CCF43391.1 - 0.14 11.2 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G MTS PF05175.9 CCF43391.1 - 0.15 11.4 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain COesterase PF00135.23 CCF43392.1 - 6.9e-11 41.5 0.0 7.8e-11 41.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.23 CCF43393.1 - 3.8e-06 25.8 0.0 4.6e-06 25.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family HsbA PF12296.3 CCF43395.1 - 4.8e-14 52.2 6.6 8.3e-14 51.5 4.6 1.4 1 0 0 1 1 1 1 Hydrophobic surface binding protein A Cation_ATPase_N PF00690.21 CCF43397.1 - 2.7e-16 58.7 0.1 3.8e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus E1-E2_ATPase PF00122.15 CCF43397.1 - 6.3e-10 38.4 0.0 2.7e-09 36.4 0.0 1.8 2 0 0 2 2 2 1 E1-E2 ATPase DUF106 PF01956.11 CCF43397.1 - 0.014 14.8 0.1 0.017 14.6 0.0 1.1 1 0 0 1 1 1 0 Integral membrane protein DUF106 DUF1129 PF06570.6 CCF43397.1 - 0.021 14.1 0.0 0.024 13.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DUF4059 PF13268.1 CCF43397.1 - 0.029 14.5 2.7 0.61 10.3 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4059) DUF3733 PF12534.3 CCF43397.1 - 0.03 13.5 0.0 0.054 12.7 0.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeat containing protein 8 DUF2208 PF09973.4 CCF43397.1 - 0.091 11.9 0.1 0.11 11.7 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) TPR_16 PF13432.1 CCF43399.1 - 1.2e-08 35.3 5.8 1e-05 26.0 0.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 CCF43399.1 - 1e-05 25.7 0.8 1e-05 25.7 0.6 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 CCF43399.1 - 6.6e-05 22.4 2.5 0.05 13.2 0.4 2.5 1 1 1 2 2 2 2 TPR repeat TPR_14 PF13428.1 CCF43399.1 - 0.00046 20.5 1.3 0.51 11.1 0.1 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 CCF43399.1 - 0.003 17.6 1.1 1.9 8.8 0.0 3.5 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 CCF43399.1 - 0.015 15.2 1.4 11 6.2 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4588 PF15251.1 CCF43399.1 - 0.046 13.6 0.2 0.077 12.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4588) HHH_8 PF14716.1 CCF43399.1 - 0.049 13.8 1.6 0.87 9.8 0.0 2.9 3 1 0 3 3 3 0 Helix-hairpin-helix domain TPR_6 PF13174.1 CCF43399.1 - 2.3 8.8 4.7 14 6.3 0.0 4.1 4 1 0 4 4 4 0 Tetratricopeptide repeat MFS_1 PF07690.11 CCF43400.1 - 8.8e-32 110.1 50.9 3.6e-29 101.5 33.7 3.3 2 1 1 3 3 3 2 Major Facilitator Superfamily NDUF_B12 PF08122.7 CCF43400.1 - 0.021 14.5 1.6 13 5.6 0.0 3.6 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase B12 subunit family HET PF06985.6 CCF43401.1 - 7.8e-33 113.5 0.0 1.6e-32 112.5 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) NOA36 PF06524.7 CCF43401.1 - 2.8 7.1 10.5 4.1 6.5 7.3 1.2 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.9 CCF43401.1 - 3.6 5.5 6.9 6.9 4.5 4.8 1.4 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.7 CCF43401.1 - 3.6 6.7 10.8 5.5 6.1 7.5 1.2 1 0 0 1 1 1 0 SDA1 adh_short PF00106.20 CCF43405.1 - 8.7e-19 68.0 0.2 1.5e-18 67.2 0.1 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF43405.1 - 3.8e-12 46.2 0.0 4.8e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF43405.1 - 2e-07 30.6 0.0 2.7e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 CCF43405.1 - 0.00025 20.8 0.0 0.00035 20.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_4 PF07993.7 CCF43405.1 - 0.021 13.7 0.0 0.035 13.0 0.0 1.5 1 1 0 1 1 1 0 Male sterility protein NAD_binding_10 PF13460.1 CCF43405.1 - 0.063 13.2 0.3 0.17 11.8 0.2 1.8 1 1 0 1 1 1 0 NADH(P)-binding Fungal_trans PF04082.13 CCF43406.1 - 2.1e-27 95.6 0.4 3e-27 95.1 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Phage_Coat_Gp8 PF05371.7 CCF43406.1 - 0.011 15.2 0.0 0.021 14.3 0.0 1.5 1 0 0 1 1 1 0 Phage major coat protein, Gp8 Shisa PF13908.1 CCF43409.1 - 0.011 15.9 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator ADH_zinc_N PF00107.21 CCF43410.1 - 4.3e-09 35.9 0.0 1e-08 34.8 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF43410.1 - 3.6e-05 23.4 0.0 8.8e-05 22.2 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ketoacyl-synt PF00109.21 CCF43411.1 - 3.8e-78 262.4 0.0 7.8e-78 261.4 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.5 CCF43411.1 - 3.5e-53 179.9 0.0 1.2e-52 178.2 0.0 1.9 2 0 0 2 2 2 1 KR domain PS-DH PF14765.1 CCF43411.1 - 1.1e-47 162.7 0.0 2.3e-47 161.6 0.0 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.16 CCF43411.1 - 2.3e-46 158.6 0.0 5e-46 157.5 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain adh_short PF00106.20 CCF43411.1 - 1.6e-41 142.0 1.1 6.5e-41 140.0 0.0 2.8 3 0 0 3 3 3 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 CCF43411.1 - 3.8e-30 104.1 0.0 8.9e-30 102.9 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.7 CCF43411.1 - 2.1e-15 56.9 0.0 6e-15 55.5 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF43411.1 - 9.1e-13 48.5 0.0 2.8e-12 46.9 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF43411.1 - 3.3e-12 46.2 0.0 6.9e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF43411.1 - 9.9e-11 41.6 0.0 2.1e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF43411.1 - 8.8e-10 39.1 0.0 3.9e-09 37.0 0.0 2.2 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF43411.1 - 3.7e-07 30.1 0.1 3.4e-06 27.0 0.0 2.8 2 0 0 2 2 1 1 Methyltransferase domain Thiolase_N PF00108.18 CCF43411.1 - 2.2e-06 26.8 0.0 1.7e-05 23.9 0.0 2.2 2 0 0 2 2 2 1 Thiolase, N-terminal domain Methyltransf_25 PF13649.1 CCF43411.1 - 3.5e-05 24.1 0.0 0.00016 21.9 0.0 2.2 2 0 0 2 2 1 1 Methyltransferase domain PP-binding PF00550.20 CCF43411.1 - 0.00013 22.1 0.5 0.00032 20.8 0.3 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site MTS PF05175.9 CCF43411.1 - 0.00095 18.5 0.0 0.0024 17.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.4 CCF43411.1 - 0.0017 17.8 0.0 0.0033 16.8 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Ubie_methyltran PF01209.13 CCF43411.1 - 0.004 16.3 0.0 0.0077 15.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family RrnaAD PF00398.15 CCF43411.1 - 0.14 11.2 0.0 0.27 10.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PCMT PF01135.14 CCF43411.1 - 0.37 10.2 0.0 0.72 9.3 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.15 CCF43411.1 - 0.61 9.1 0.0 1 8.3 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase HIG_1_N PF04588.8 CCF43412.1 - 3.7e-22 77.8 0.6 7.2e-22 76.8 0.4 1.5 1 0 0 1 1 1 1 Hypoxia induced protein conserved region DUF1772 PF08592.6 CCF43412.1 - 0.063 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) Git3 PF11710.3 CCF43413.1 - 2.2e-64 216.7 11.9 4e-64 215.8 8.2 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Git3_C PF11970.3 CCF43413.1 - 2.1e-21 75.4 0.3 2.1e-21 75.4 0.2 1.9 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term 7tm_1 PF00001.16 CCF43413.1 - 8.2e-07 28.4 0.2 1.4e-06 27.6 0.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2763 PF10961.3 CCF43416.1 - 9.1 6.7 18.0 7.4 7.0 4.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2763) ApbA_C PF08546.6 CCF43417.1 - 4.3e-28 97.8 0.1 6.5e-28 97.2 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 CCF43417.1 - 3.6e-23 81.6 0.0 5.4e-23 81.1 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ThiF PF00899.16 CCF43417.1 - 0.14 11.9 0.7 0.28 11.0 0.5 1.5 1 0 0 1 1 1 0 ThiF family DNA_binding_1 PF01035.15 CCF43418.1 - 4.9e-06 26.1 0.0 6e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Fib_alpha PF08702.5 CCF43419.1 - 0.061 13.4 33.5 0.043 13.9 4.7 4.4 2 1 1 4 4 4 0 Fibrinogen alpha/beta chain family IncA PF04156.9 CCF43419.1 - 0.069 12.7 60.7 0.014 14.9 6.3 4.2 2 1 2 4 4 4 0 IncA protein AlkA_N PF06029.6 CCF43419.1 - 0.072 13.1 2.4 0.2 11.7 0.3 2.7 2 0 0 2 2 2 0 AlkA N-terminal domain Reo_sigmaC PF04582.7 CCF43419.1 - 1.9 7.6 20.4 0.3 10.2 4.4 3.5 2 1 1 3 3 3 0 Reovirus sigma C capsid protein Hormone_1 PF00103.15 CCF43419.1 - 1.9 7.7 12.2 0.75 9.1 0.1 3.2 2 1 1 3 3 3 0 Somatotropin hormone family DUF812 PF05667.6 CCF43419.1 - 4 5.8 55.8 0.018 13.6 6.4 4.0 3 2 0 3 3 3 0 Protein of unknown function (DUF812) Tropomyosin PF00261.15 CCF43419.1 - 5.3 6.0 62.5 0.3 10.1 9.4 4.0 2 1 1 3 3 3 0 Tropomyosin MscS_porin PF12795.2 CCF43419.1 - 9.2 5.4 63.1 0.71 9.1 9.9 4.5 2 1 1 4 4 4 0 Mechanosensitive ion channel porin domain DUF3618 PF12277.3 CCF43420.1 - 0.011 15.7 0.9 0.026 14.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3618) UFC1 PF08694.6 CCF43420.1 - 0.13 11.7 0.1 0.44 10.0 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin-fold modifier-conjugating enzyme 1 Glyco_hydro_47 PF01532.15 CCF43421.1 - 5e-121 404.5 0.0 6.4e-121 404.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 OSR1_C PF12202.3 CCF43421.1 - 0.0069 15.9 0.1 0.027 14.0 0.1 2.0 2 0 0 2 2 2 1 Oxidative-stress-responsive kinase 1 C terminal DUF1649 PF07855.7 CCF43422.1 - 6.8e-64 214.4 0.0 7.8e-64 214.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1649) Mo-co_dimer PF03404.11 CCF43422.1 - 0.043 13.4 0.2 0.065 12.8 0.1 1.2 1 0 0 1 1 1 0 Mo-co oxidoreductase dimerisation domain Ribosomal_S8e PF01201.17 CCF43424.1 - 4.1e-48 162.8 2.1 4.8e-48 162.6 1.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e SMAP PF15477.1 CCF43424.1 - 0.036 14.3 5.2 0.13 12.5 3.6 2.0 1 1 0 1 1 1 0 Small acidic protein family RabGAP-TBC PF00566.13 CCF43425.1 - 5e-49 166.6 1.3 2.3e-47 161.2 0.9 2.4 1 1 0 1 1 1 1 Rab-GTPase-TBC domain HALZ PF02183.13 CCF43425.1 - 0.0094 15.6 17.0 0.052 13.2 1.5 3.4 2 1 1 3 3 3 2 Homeobox associated leucine zipper CCDC155 PF14662.1 CCF43425.1 - 0.11 12.1 29.1 0.58 9.7 18.0 2.4 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 DUF1640 PF07798.6 CCF43425.1 - 0.41 10.6 21.2 4.2 7.3 10.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) Microtub_assoc PF07989.6 CCF43425.1 - 1.5 8.7 27.9 0.072 12.9 4.8 3.2 3 0 0 3 3 3 0 Microtubule associated ADIP PF11559.3 CCF43425.1 - 7.4 6.4 35.0 2.7 7.9 7.4 3.3 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Glyco_hydro_63 PF03200.11 CCF43426.1 - 8.6e-189 629.1 0.1 9.9e-188 625.6 0.1 1.9 1 1 0 1 1 1 1 Mannosyl oligosaccharide glucosidase Trehalase PF01204.13 CCF43426.1 - 5.9e-09 35.0 0.0 9.3e-09 34.4 0.0 1.2 1 0 0 1 1 1 1 Trehalase GDE_C PF06202.9 CCF43426.1 - 0.012 14.3 0.0 0.018 13.7 0.0 1.3 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase MFS_1 PF07690.11 CCF43427.1 - 7.9e-12 44.5 17.0 7.9e-12 44.5 11.8 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily p450 PF00067.17 CCF43428.1 - 2.7e-17 62.4 0.0 3.1e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 CCF43429.1 - 1.8e-71 241.0 0.0 2.1e-71 240.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 PALP PF00291.20 CCF43430.1 - 2.1e-15 56.7 0.6 2.4e-15 56.5 0.4 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme IU_nuc_hydro PF01156.14 CCF43430.1 - 0.12 11.5 0.0 0.14 11.3 0.0 1.0 1 0 0 1 1 1 0 Inosine-uridine preferring nucleoside hydrolase DIT1_PvcA PF05141.7 CCF43431.1 - 2.4e-87 292.8 0.0 3e-87 292.4 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein Dynamin_N PF00350.18 CCF43432.1 - 4.9e-29 101.2 0.0 1.2e-28 100.0 0.0 1.7 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 CCF43432.1 - 1.4e-10 40.4 0.1 6e-10 38.3 0.0 2.0 2 0 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.18 CCF43432.1 - 1.9e-05 24.6 0.0 6.2e-05 22.9 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CCF43432.1 - 0.0034 17.8 0.0 0.0097 16.3 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein ABC_tran PF00005.22 CCF43432.1 - 0.022 15.0 0.0 0.075 13.3 0.0 1.9 1 0 0 1 1 1 0 ABC transporter DUF3141 PF11339.3 CCF43432.1 - 0.079 11.2 1.1 0.12 10.7 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) AAA_21 PF13304.1 CCF43432.1 - 0.16 11.9 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF2077 PF09850.4 CCF43432.1 - 0.23 10.8 2.1 15 4.9 0.0 2.7 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2077) AAA_23 PF13476.1 CCF43432.1 - 0.56 10.4 0.0 0.56 10.4 0.0 2.4 3 1 0 3 3 3 0 AAA domain p450 PF00067.17 CCF43434.1 - 0.015 13.8 0.0 0.022 13.2 0.0 1.2 1 0 0 1 1 1 0 Cytochrome P450 ERG4_ERG24 PF01222.12 CCF43435.1 - 4e-54 183.7 0.1 4.6e-54 183.6 0.0 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 CCF43435.1 - 0.00094 18.5 0.8 0.0021 17.3 0.2 1.8 2 1 0 2 2 2 1 Protein of unknown function (DUF1295) Prefoldin PF02996.12 CCF43437.1 - 0.061 12.9 0.5 0.12 11.9 0.3 1.5 1 0 0 1 1 1 0 Prefoldin subunit DUF2414 PF10309.4 CCF43438.1 - 2.4e-20 71.9 0.0 3.9e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2414) Apolipoprotein PF01442.13 CCF43439.1 - 0.0079 15.7 4.7 0.015 14.8 3.3 1.4 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Moulting_cycle PF04870.11 CCF43439.1 - 0.019 14.0 0.0 0.027 13.5 0.0 1.1 1 0 0 1 1 1 0 Moulting cycle IncA PF04156.9 CCF43439.1 - 0.024 14.2 14.7 0.083 12.4 10.2 1.8 1 1 0 1 1 1 0 IncA protein SH3BP5 PF05276.9 CCF43439.1 - 0.043 13.1 2.9 0.062 12.6 2.0 1.1 1 0 0 1 1 1 0 SH3 domain-binding protein 5 (SH3BP5) Seryl_tRNA_N PF02403.17 CCF43439.1 - 0.049 13.6 0.6 13 5.8 0.1 2.5 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Spectrin PF00435.16 CCF43439.1 - 0.081 13.2 7.0 0.088 13.1 2.2 2.2 1 1 1 2 2 2 0 Spectrin repeat HWE_HK PF07536.9 CCF43439.1 - 0.12 12.8 2.6 8.7 6.8 0.0 2.6 1 1 0 2 2 2 0 HWE histidine kinase Tropomyosin_1 PF12718.2 CCF43439.1 - 0.16 11.8 12.0 0.62 9.9 2.0 2.3 1 1 1 2 2 2 0 Tropomyosin like Baculo_PEP_C PF04513.7 CCF43439.1 - 0.16 11.7 0.1 0.4 10.5 0.1 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus GrpE PF01025.14 CCF43439.1 - 0.2 11.2 1.8 0.32 10.5 1.3 1.3 1 0 0 1 1 1 0 GrpE FliD_C PF07195.7 CCF43439.1 - 0.5 9.6 2.3 0.53 9.5 0.1 1.8 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Sugarporin_N PF11471.3 CCF43439.1 - 0.5 10.0 8.8 1.6 8.4 0.1 2.4 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension PhoU_div PF01865.11 CCF43439.1 - 0.54 9.3 3.6 0.56 9.3 0.3 1.9 1 1 0 2 2 2 0 Protein of unknown function DUF47 Tropomyosin PF00261.15 CCF43439.1 - 0.69 8.9 10.7 1.7 7.6 2.0 2.1 1 1 1 2 2 2 0 Tropomyosin DUF3847 PF12958.2 CCF43439.1 - 1 9.1 4.9 1.3 8.8 0.4 2.5 2 1 0 3 3 3 0 Protein of unknown function (DUF3847) BLOC1_2 PF10046.4 CCF43439.1 - 1.1 9.4 2.8 9.4 6.4 0.1 2.6 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 OEP PF02321.13 CCF43439.1 - 1.3 8.6 8.0 0.59 9.6 0.2 2.2 2 0 0 2 2 2 0 Outer membrane efflux protein DUF16 PF01519.11 CCF43439.1 - 1.3 9.3 3.5 4.3 7.6 2.4 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF1664 PF07889.7 CCF43439.1 - 2 8.2 4.6 5 6.9 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Spc7 PF08317.6 CCF43439.1 - 4.6 5.7 8.1 2.2 6.8 2.1 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein Nup54 PF13874.1 CCF43439.1 - 8.9 5.9 8.4 12 5.5 0.5 2.4 1 1 0 2 2 2 0 Nucleoporin complex subunit 54 BTB PF00651.26 CCF43440.1 - 3.1e-05 23.9 1.6 0.00016 21.6 0.1 2.4 2 1 1 3 3 3 1 BTB/POZ domain Amidohydro_2 PF04909.9 CCF43441.1 - 3.3e-15 56.3 0.1 4e-15 56.1 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase zf-TFIIB PF13453.1 CCF43442.1 - 0.85 8.8 9.6 3.7 6.8 0.1 3.0 3 0 0 3 3 3 0 Transcription factor zinc-finger DUF3587 PF12132.3 CCF43442.1 - 2.5 7.2 7.8 2.8 7.1 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3587) PolC_DP2 PF03833.8 CCF43442.1 - 2.6 5.6 6.6 2.6 5.5 4.6 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 AMP-binding PF00501.23 CCF43444.1 - 5.2e-35 120.6 0.0 7.4e-35 120.1 0.0 1.3 1 1 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.7 CCF43444.1 - 3e-10 39.4 0.1 5e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.20 CCF43444.1 - 1.5e-07 31.5 0.0 2.8e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.20 CCF43444.1 - 0.0025 17.7 0.6 0.0067 16.3 0.3 1.8 2 0 0 2 2 2 1 short chain dehydrogenase Semialdhyde_dh PF01118.19 CCF43444.1 - 0.021 15.1 0.2 0.15 12.3 0.1 2.4 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain KR PF08659.5 CCF43444.1 - 0.077 12.6 0.2 0.14 11.7 0.1 1.4 1 0 0 1 1 1 0 KR domain Polysacc_synt_2 PF02719.10 CCF43444.1 - 0.13 11.1 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Carb_anhydrase PF00194.16 CCF43445.1 - 1.9e-23 82.7 0.0 2.8e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Polyketide_cyc2 PF10604.4 CCF43446.1 - 3e-16 59.8 0.0 3.3e-16 59.7 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.15 CCF43446.1 - 0.024 14.6 0.0 0.025 14.5 0.0 1.4 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport PI-PLC-X PF00388.14 CCF43448.1 - 6.6e-63 210.4 0.0 9.6e-63 209.9 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 CCF43448.1 - 4.4e-07 29.8 0.0 7.5e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain LRR_6 PF13516.1 CCF43450.1 - 1.2e-17 61.9 7.8 0.025 14.6 0.0 8.5 9 0 0 9 9 9 5 Leucine Rich repeat LRR_1 PF00560.28 CCF43450.1 - 6.4e-11 40.7 3.0 1.6 9.0 0.1 8.1 7 2 1 8 8 8 2 Leucine Rich Repeat LRR_8 PF13855.1 CCF43450.1 - 2.3e-08 33.6 1.5 0.0034 17.0 0.1 4.4 3 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.2 CCF43450.1 - 1.1e-07 31.3 0.0 0.31 10.7 0.0 4.6 5 0 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 CCF43450.1 - 0.0057 16.6 14.4 10 6.8 0.0 7.1 8 1 0 8 8 8 2 Leucine rich repeat Ste50p-SAM PF09235.5 CCF43450.1 - 0.021 14.8 0.7 0.97 9.5 0.0 3.3 4 0 0 4 4 4 0 Ste50p, sterile alpha motif MFS_1 PF07690.11 CCF43452.1 - 1.7e-27 96.0 30.3 1.7e-27 96.0 21.0 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4131 PF13567.1 CCF43452.1 - 0.3 10.4 0.0 0.3 10.4 0.0 3.5 3 1 1 4 4 4 0 Domain of unknown function (DUF4131) FAD_binding_4 PF01565.18 CCF43454.1 - 5.9e-29 100.3 1.8 8.5e-29 99.8 1.2 1.2 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 CCF43454.1 - 1.2e-13 50.6 0.0 2.4e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like DUF3857 PF12969.2 CCF43454.1 - 0.1 12.1 0.0 1.7 8.2 0.0 2.1 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3857) Glyco_hydro_43 PF04616.9 CCF43455.1 - 4.6e-41 140.7 1.7 5.1e-41 140.6 1.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 APH PF01636.18 CCF43456.1 - 7.1e-05 22.6 0.0 8e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.20 CCF43456.1 - 0.0038 16.4 0.0 0.0051 15.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Choline_kinase PF01633.15 CCF43456.1 - 0.063 12.8 0.1 0.089 12.3 0.1 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase NmrA PF05368.8 CCF43457.1 - 9.6e-09 34.8 0.1 1.4e-08 34.2 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family Fungal_trans PF04082.13 CCF43458.1 - 2.5e-29 101.9 0.0 3.6e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF43458.1 - 5.3e-07 29.4 7.2 9e-07 28.7 5.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tannase PF07519.6 CCF43460.1 - 1e-90 304.7 0.0 1.3e-90 304.4 0.0 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_6 PF12697.2 CCF43460.1 - 0.0021 17.9 0.1 0.0071 16.2 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF43460.1 - 0.03 13.5 0.0 0.69 9.0 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family Glyco_hydro_61 PF03443.9 CCF43462.1 - 3.3e-37 128.4 0.3 4.4e-37 128.0 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 TPR_12 PF13424.1 CCF43463.1 - 1.3e-12 47.5 0.3 0.00028 20.7 0.1 3.7 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 CCF43463.1 - 1.5e-07 30.7 1.5 8 6.6 0.3 6.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.1 CCF43463.1 - 1e-05 25.0 0.3 0.063 12.9 0.0 4.1 2 1 2 4 4 4 1 TPR repeat TPR_8 PF13181.1 CCF43463.1 - 2.2e-05 23.8 0.3 0.73 9.7 0.0 5.2 6 0 0 6 6 6 1 Tetratricopeptide repeat HET PF06985.6 CCF43463.1 - 0.0026 17.9 0.1 0.0083 16.2 0.1 1.8 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) TPR_1 PF00515.23 CCF43463.1 - 0.0028 17.1 0.0 21 4.9 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.1 CCF43463.1 - 0.017 14.8 0.0 32 4.6 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Ank_4 PF13637.1 CCF43463.1 - 0.054 14.0 0.0 0.15 12.6 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) TIR_2 PF13676.1 CCF43463.1 - 0.097 12.8 0.7 0.4 10.8 0.0 2.4 3 0 0 3 3 3 0 TIR domain Baculo_PEP_C PF04513.7 CCF43464.1 - 0.19 11.5 13.6 2.2 8.1 9.2 2.4 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus MFS_1 PF07690.11 CCF43465.1 - 4.2e-20 71.7 14.5 5.3e-20 71.4 10.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily GrpE PF01025.14 CCF43466.1 - 9.3e-53 178.1 2.9 1.2e-52 177.8 2.0 1.1 1 0 0 1 1 1 1 GrpE RNA_pol_A_bac PF01000.21 CCF43467.1 - 9.4e-34 115.9 0.0 1.5e-33 115.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 CCF43467.1 - 7.5e-15 53.8 0.0 9.6e-15 53.4 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Sulfotransfer_3 PF13469.1 CCF43468.1 - 1.9e-10 41.8 3.1 2.4e-10 41.5 2.1 1.2 1 0 0 1 1 1 1 Sulfotransferase family DUF2611 PF11022.3 CCF43469.1 - 8.5 6.5 7.0 28 4.9 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2611) UDPGT PF00201.13 CCF43473.1 - 9.4e-10 37.6 0.1 9.7e-10 37.5 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 CCF43473.1 - 0.0096 15.5 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain p450 PF00067.17 CCF43474.1 - 1.2e-32 113.0 0.0 1.4e-32 112.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TAXi_C PF14541.1 CCF43474.1 - 0.056 12.9 0.0 0.086 12.3 0.0 1.3 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal Reticulon PF02453.12 CCF43474.1 - 0.12 11.9 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Reticulon CN_hydrolase PF00795.17 CCF43475.1 - 1.9e-22 79.5 0.0 2.2e-22 79.3 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase HAD PF12710.2 CCF43476.1 - 2e-07 31.3 0.0 2.6e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Methyltransf_23 PF13489.1 CCF43477.1 - 3.6e-19 69.0 0.0 5.7e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF43477.1 - 2.2e-10 40.2 0.0 3.9e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF43477.1 - 3.2e-09 37.3 0.0 1.4e-08 35.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF43477.1 - 2.6e-08 34.2 0.0 5.4e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF43477.1 - 6.9e-08 32.8 0.0 2.8e-07 30.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF43477.1 - 1.2e-05 25.6 0.0 2.1e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF43477.1 - 0.001 18.1 0.0 0.0025 16.8 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.9 CCF43477.1 - 0.0016 17.8 0.0 0.0027 17.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 CCF43477.1 - 0.0056 16.6 0.0 0.036 14.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 CCF43477.1 - 0.0076 16.2 0.0 0.012 15.5 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase Ubie_methyltran PF01209.13 CCF43477.1 - 0.016 14.3 0.0 0.77 8.8 0.0 2.5 1 1 1 2 2 2 0 ubiE/COQ5 methyltransferase family CMAS PF02353.15 CCF43477.1 - 0.022 13.8 0.0 0.051 12.6 0.0 1.6 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.8 CCF43477.1 - 0.032 13.3 0.0 0.1 11.7 0.0 1.8 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.14 CCF43477.1 - 0.13 11.8 0.2 3.5 7.1 0.0 3.0 3 1 0 3 3 3 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) p450 PF00067.17 CCF43478.1 - 5.6e-62 209.7 0.0 7.5e-62 209.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.20 CCF43479.1 - 2.1e-22 79.7 0.0 2.7e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF43479.1 - 2e-07 30.8 0.0 2.9e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF43479.1 - 2.9e-07 30.5 0.0 4.2e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Shikimate_DH PF01488.15 CCF43479.1 - 7.3e-06 26.1 0.0 1.3e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.12 CCF43479.1 - 4.6e-05 23.7 0.2 9.2e-05 22.8 0.2 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.16 CCF43479.1 - 0.00054 19.4 0.0 0.00064 19.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.13 CCF43479.1 - 0.0021 17.7 0.1 0.0039 16.8 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_10 PF13460.1 CCF43479.1 - 0.0024 17.8 0.1 0.004 17.1 0.1 1.3 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_2 PF03446.10 CCF43479.1 - 0.0078 16.0 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Polysacc_synt_2 PF02719.10 CCF43479.1 - 0.0079 15.1 0.1 0.011 14.7 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.8 CCF43479.1 - 0.073 12.3 0.1 0.1 11.8 0.1 1.2 1 0 0 1 1 1 0 NmrA-like family Melibiase PF02065.13 CCF43480.1 - 6.5e-13 48.1 0.0 1.7e-07 30.3 0.0 2.4 2 1 0 2 2 2 2 Melibiase DUF905 PF06006.7 CCF43480.1 - 0.019 14.2 0.1 0.07 12.5 0.0 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF905) Peptidase_S8 PF00082.17 CCF43481.1 - 2.3e-43 148.3 6.1 3.6e-43 147.7 4.2 1.3 1 0 0 1 1 1 1 Subtilase family PA PF02225.17 CCF43481.1 - 5.2e-10 38.9 0.0 1.5e-09 37.4 0.0 1.8 1 0 0 1 1 1 1 PA domain DUF1034 PF06280.7 CCF43481.1 - 4.9e-07 30.1 0.3 1.7e-05 25.1 0.0 2.6 2 0 0 2 2 2 1 Fn3-like domain (DUF1034) Spc24 PF08286.6 CCF43483.1 - 1.5e-25 89.2 0.0 1.5e-25 89.1 0.0 1.0 1 0 0 1 1 1 1 Spc24 subunit of Ndc80 ABC_tran PF00005.22 CCF43484.1 - 1.9e-19 70.2 0.6 3.6e-19 69.4 0.4 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.2 CCF43484.1 - 7.6e-17 61.3 1.7 1.4e-11 44.0 0.2 2.3 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.1 CCF43484.1 - 8e-11 42.4 0.3 0.00011 22.2 0.2 2.3 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 CCF43484.1 - 8.6e-06 25.2 0.1 2.4e-05 23.7 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.14 CCF43484.1 - 3.3e-05 23.2 0.2 0.063 12.5 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 CCF43484.1 - 0.005 17.2 0.8 0.0095 16.2 0.5 1.4 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.1 CCF43484.1 - 0.56 9.2 0.0 0.88 8.5 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain GMC_oxred_C PF05199.8 CCF43486.1 - 1.1e-38 132.7 0.0 1.6e-38 132.2 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase MFS_1 PF07690.11 CCF43487.1 - 3.5e-10 39.1 8.8 3.5e-10 39.1 6.1 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF43487.1 - 2.2e-06 26.5 6.3 3.5e-06 25.8 4.4 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter LacAB_rpiB PF02502.13 CCF43487.1 - 0.063 12.9 0.5 0.13 11.9 0.4 1.4 1 0 0 1 1 1 0 Ribose/Galactose Isomerase PALP PF00291.20 CCF43490.1 - 4.2e-73 246.2 0.3 5.1e-73 245.9 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.13 CCF43490.1 - 4.6e-42 141.5 0.0 7.1e-22 76.8 0.0 2.3 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase p450 PF00067.17 CCF43491.1 - 4.3e-22 78.2 0.0 4.4e-22 78.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Helicase_C_3 PF13625.1 CCF43492.1 - 1.1e-23 83.3 0.0 1.9e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF43492.1 - 4.2e-07 29.9 0.0 8.9e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AChE_tetra PF08674.5 CCF43492.1 - 4.1 7.0 7.7 12 5.5 5.3 1.6 1 1 0 1 1 1 0 Acetylcholinesterase tetramerisation domain zf-CHY PF05495.7 CCF43493.1 - 1.4e-13 50.7 21.0 1.8e-13 50.3 14.5 1.1 1 0 0 1 1 1 1 CHY zinc finger Zn_Tnp_IS1595 PF12760.2 CCF43493.1 - 0.29 10.9 12.4 4.5 7.1 5.8 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-RING_3 PF14369.1 CCF43493.1 - 0.84 9.6 10.5 0.27 11.2 3.8 2.5 1 1 1 2 2 2 0 zinc-finger HypA PF01155.14 CCF43493.1 - 1.2 8.8 12.0 0.049 13.3 3.0 2.0 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family Cytochrome_C7 PF14522.1 CCF43493.1 - 1.3 8.6 16.0 2 8.0 11.1 1.3 1 0 0 1 1 1 0 Cytochrome c7 C1_4 PF07975.7 CCF43493.1 - 1.5 8.9 17.4 1.4 9.0 5.1 2.7 1 1 2 3 3 3 0 TFIIH C1-like domain Zn-ribbon_8 PF09723.5 CCF43493.1 - 2.5 8.1 16.8 5.3 7.0 6.3 2.6 1 1 1 2 2 2 0 Zinc ribbon domain Evr1_Alr PF04777.8 CCF43493.1 - 3.1 7.7 12.1 66 3.4 8.3 2.4 1 1 0 1 1 1 0 Erv1 / Alr family Proteasome PF00227.21 CCF43494.1 - 8.8e-55 184.9 0.1 1.3e-54 184.3 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 CCF43494.1 - 1.8e-12 46.3 0.1 1.8e-12 46.3 0.1 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Zn_clus PF00172.13 CCF43495.1 - 5.8e-07 29.3 10.4 9.8e-07 28.5 7.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD-oxidase_C PF02913.14 CCF43496.1 - 7.4e-60 202.3 0.0 1.2e-59 201.7 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 CCF43496.1 - 1e-38 131.9 0.3 1.8e-38 131.1 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain Cupredoxin_1 PF13473.1 CCF43497.1 - 0.058 13.2 0.2 0.12 12.2 0.1 1.6 1 1 0 1 1 1 0 Cupredoxin-like domain GRP PF07172.6 CCF43497.1 - 0.095 13.1 14.7 0.23 11.9 10.2 1.6 1 0 0 1 1 1 0 Glycine rich protein family zf-LYAR PF08790.6 CCF43498.1 - 8.9e-15 54.0 2.5 1.6e-14 53.2 1.7 1.5 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger RmlD_sub_bind PF04321.12 CCF43499.1 - 3.1e-54 183.8 0.0 3.7e-54 183.5 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.16 CCF43499.1 - 4e-23 82.0 0.0 1.6e-22 80.1 0.0 1.8 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 CCF43499.1 - 6.8e-14 51.3 0.0 7.5e-12 44.7 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.10 CCF43499.1 - 2.3e-07 30.0 0.3 3.9e-05 22.6 0.0 2.9 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 CCF43499.1 - 4e-07 29.0 0.0 1.1e-06 27.5 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 CCF43499.1 - 4e-06 26.9 0.1 5e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 CCF43499.1 - 0.0011 18.8 1.8 0.12 12.2 1.2 2.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF43499.1 - 0.042 13.4 0.3 7.5 6.1 0.0 2.5 2 0 0 2 2 2 0 KR domain NmrA PF05368.8 CCF43499.1 - 0.06 12.5 0.3 1.1 8.5 0.1 2.2 2 0 0 2 2 2 0 NmrA-like family Ammonium_transp PF00909.16 CCF43500.1 - 1.2e-116 389.5 30.8 1.4e-116 389.3 21.3 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF2207 PF09972.4 CCF43500.1 - 6.9 5.1 7.7 6 5.3 0.4 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Abhydrolase_4 PF08386.5 CCF43501.1 - 8e-15 54.5 0.0 2.4e-14 53.0 0.0 1.7 2 0 0 2 2 2 1 TAP-like protein Abhydrolase_5 PF12695.2 CCF43501.1 - 0.0041 16.8 0.0 0.018 14.7 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF43501.1 - 0.005 16.7 0.2 0.0067 16.3 0.2 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family EF_assoc_2 PF08356.7 CCF43503.1 - 6.5e-35 118.7 0.0 1.2e-34 117.8 0.0 1.5 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.7 CCF43503.1 - 5.1e-33 112.1 0.7 1.1e-32 111.0 0.5 1.6 1 0 0 1 1 1 1 EF hand associated Miro PF08477.8 CCF43503.1 - 3e-22 79.3 0.0 2e-14 54.1 0.0 2.8 2 1 1 3 3 3 2 Miro-like protein Ras PF00071.17 CCF43503.1 - 1.5e-12 47.2 0.0 3.7e-06 26.4 0.0 2.2 2 0 0 2 2 2 2 Ras family EF-hand_7 PF13499.1 CCF43503.1 - 1.3e-08 34.8 0.7 0.00031 20.8 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 CCF43503.1 - 5.8e-08 31.4 2.6 0.0031 16.7 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 CCF43503.1 - 2e-06 27.2 4.5 0.034 14.0 0.1 2.9 2 1 1 3 3 3 2 EF-hand domain EF-hand_5 PF13202.1 CCF43503.1 - 1.7e-05 23.8 5.1 0.12 11.7 1.9 2.8 2 0 0 2 2 2 2 EF hand AAA_29 PF13555.1 CCF43503.1 - 0.001 18.5 0.0 0.0023 17.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 CCF43503.1 - 0.0022 18.0 0.0 0.0046 16.9 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain EF-hand_8 PF13833.1 CCF43503.1 - 0.012 15.1 3.9 1.7 8.3 0.1 2.5 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_10 PF14788.1 CCF43503.1 - 0.019 14.6 1.6 0.18 11.5 0.1 2.4 2 0 0 2 2 2 0 EF hand MMR_HSR1 PF01926.18 CCF43503.1 - 0.086 12.8 0.0 0.23 11.4 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.1 CCF43503.1 - 0.088 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 CCF43503.1 - 0.13 12.5 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 ABC transporter DUF258 PF03193.11 CCF43503.1 - 0.14 11.3 0.0 0.28 10.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 RRM_1 PF00076.17 CCF43506.1 - 1e-43 146.8 0.6 6.9e-20 70.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF43506.1 - 4.1e-33 113.1 0.1 2.9e-16 59.1 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.1 CCF43506.1 - 4.1e-30 103.8 0.2 8.6e-30 102.8 0.1 1.5 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_5 PF13893.1 CCF43506.1 - 6.7e-22 77.0 0.0 5.8e-08 32.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 CCF43506.1 - 0.00097 18.9 0.2 0.031 14.1 0.0 2.7 2 1 0 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.1 CCF43506.1 - 0.022 14.5 0.0 2.1 8.2 0.0 2.6 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Cyt-b5 PF00173.23 CCF43507.1 - 2.2e-18 65.7 0.3 9.4e-18 63.7 0.0 2.1 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.8 CCF43507.1 - 1.6e-07 31.6 21.0 1.6e-07 31.6 14.6 1.7 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.8 CCF43507.1 - 0.0047 16.9 0.1 0.011 15.7 0.1 1.6 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Het-C PF07217.6 CCF43508.1 - 2.5e-175 584.1 0.0 2.8e-175 584.0 0.0 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C Fungal_trans_2 PF11951.3 CCF43509.1 - 1.4e-23 83.1 11.3 1.2e-19 70.2 1.6 2.6 3 0 0 3 3 3 2 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF43509.1 - 0.00011 21.9 1.8 0.00019 21.2 1.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Suf PF05843.9 CCF43509.1 - 0.078 12.6 5.4 0.12 12.0 3.7 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DDHD PF02862.12 CCF43509.1 - 0.21 11.3 5.2 0.39 10.4 3.6 1.4 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.7 CCF43509.1 - 0.72 9.6 5.6 1.1 9.0 3.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF605 PF04652.11 CCF43509.1 - 1.2 8.4 13.7 2.1 7.6 9.5 1.3 1 0 0 1 1 1 0 Vta1 like Zip PF02535.17 CCF43509.1 - 1.3 7.9 2.8 2.2 7.1 1.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter AvrE PF11725.3 CCF43509.1 - 4.1 4.3 13.1 6.4 3.6 9.1 1.2 1 0 0 1 1 1 0 Pathogenicity factor EutQ PF06249.7 CCF43510.1 - 9.3e-13 47.9 0.0 1.2e-12 47.6 0.0 1.0 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_3 PF05899.7 CCF43510.1 - 1.5e-11 43.4 0.1 3.1e-11 42.4 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF861) Cupin_2 PF07883.6 CCF43510.1 - 2.6e-05 23.6 0.0 4e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Cupin domain KduI PF04962.7 CCF43510.1 - 0.0048 16.0 0.0 0.0051 15.9 0.0 1.1 1 0 0 1 1 1 1 KduI/IolB family Cupin_6 PF12852.2 CCF43510.1 - 0.0053 16.3 0.0 0.0062 16.1 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_1 PF00190.17 CCF43510.1 - 0.036 13.5 0.0 0.036 13.4 0.0 1.1 1 0 0 1 1 1 0 Cupin SNARE PF05739.14 CCF43512.1 - 1e-12 47.5 5.5 1.7e-12 46.8 3.8 1.4 1 0 0 1 1 1 1 SNARE domain YebO PF13974.1 CCF43512.1 - 1 9.1 5.8 6.9 6.5 4.0 1.9 1 1 0 1 1 1 0 YebO-like protein SlyX PF04102.7 CCF43512.1 - 2.4 8.5 5.8 4.4 7.7 1.7 2.1 1 1 1 2 2 2 0 SlyX PIF1 PF05970.9 CCF43513.1 - 9.7e-32 110.3 0.6 2.2e-28 99.2 0.1 3.3 2 1 1 3 3 3 2 PIF1-like helicase AAA_30 PF13604.1 CCF43513.1 - 6.3e-14 52.0 0.0 1.1e-11 44.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain Cauli_VI PF01693.11 CCF43513.1 - 2.8e-13 49.6 1.5 5.5e-13 48.7 1.1 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin AAA_22 PF13401.1 CCF43513.1 - 7.5e-06 26.1 0.0 2.3e-05 24.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 CCF43513.1 - 1e-05 25.2 0.0 1.8e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 CCF43513.1 - 3.6e-05 23.8 0.0 0.00011 22.3 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 CCF43513.1 - 3.8e-05 23.3 0.0 8.9e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_14 PF13173.1 CCF43513.1 - 9.4e-05 22.3 0.0 0.00028 20.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 CCF43513.1 - 0.00017 21.7 0.0 0.00028 21.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 CCF43513.1 - 0.00089 19.3 0.0 0.0018 18.3 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain IstB_IS21 PF01695.12 CCF43513.1 - 0.0013 18.2 0.8 0.78 9.1 0.0 2.2 1 1 1 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.16 CCF43513.1 - 0.0023 17.1 0.1 0.0058 15.8 0.1 1.6 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_29 PF13555.1 CCF43513.1 - 0.004 16.6 0.0 0.009 15.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain DEAD PF00270.24 CCF43513.1 - 0.0042 16.5 0.2 1.8 8.0 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase ABC_tran PF00005.22 CCF43513.1 - 0.0066 16.7 0.0 0.016 15.4 0.0 1.6 1 0 0 1 1 1 1 ABC transporter Viral_helicase1 PF01443.13 CCF43513.1 - 0.015 14.8 0.1 0.045 13.2 0.1 1.8 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.17 CCF43513.1 - 0.015 14.1 0.1 0.028 13.2 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain T2SE PF00437.15 CCF43513.1 - 0.016 14.1 0.0 0.026 13.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF815 PF05673.8 CCF43513.1 - 0.018 14.0 0.1 0.032 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.21 CCF43513.1 - 0.019 14.4 0.1 0.065 12.7 0.1 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.17 CCF43513.1 - 0.019 15.1 0.7 0.071 13.2 0.1 2.2 2 1 0 2 2 2 0 RNA helicase NTPase_1 PF03266.10 CCF43513.1 - 0.023 14.3 0.3 0.65 9.6 0.1 2.3 2 0 0 2 2 2 0 NTPase AAA_10 PF12846.2 CCF43513.1 - 0.032 13.6 0.2 0.075 12.4 0.1 1.6 1 0 0 1 1 1 0 AAA-like domain AAA_28 PF13521.1 CCF43513.1 - 0.039 13.9 0.5 0.18 11.7 0.1 2.4 2 1 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 CCF43513.1 - 0.044 13.4 0.1 0.16 11.6 0.1 1.8 1 1 0 1 1 1 0 Archaeal ATPase AAA_18 PF13238.1 CCF43513.1 - 0.087 13.1 0.0 0.29 11.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 CCF43513.1 - 0.11 12.9 0.0 0.29 11.6 0.0 1.7 1 1 0 1 1 1 0 Miro-like protein ATP-synt_ab PF00006.20 CCF43513.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain FtsK_SpoIIIE PF01580.13 CCF43513.1 - 0.16 11.4 0.0 0.31 10.4 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family APS_kinase PF01583.15 CCF43513.1 - 0.16 11.6 0.2 0.46 10.1 0.0 1.8 2 0 0 2 2 2 0 Adenylylsulphate kinase PhoH PF02562.11 CCF43513.1 - 0.16 11.1 0.0 0.3 10.2 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ArgK PF03308.11 CCF43513.1 - 0.18 10.5 0.1 0.29 9.8 0.1 1.2 1 0 0 1 1 1 0 ArgK protein SH3_1 PF00018.23 CCF43514.1 - 1.4e-09 37.1 0.5 2.5e-09 36.3 0.0 1.7 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.1 CCF43514.1 - 2.2e-07 30.3 0.0 4.6e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 CCF43514.1 - 1.1e-06 28.0 0.0 1.9e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF2417 PF10329.4 CCF43514.1 - 0.17 11.2 9.5 0.31 10.4 6.6 1.4 1 1 0 1 1 1 0 Region of unknown function (DUF2417) DUF1516 PF07457.6 CCF43514.1 - 0.9 9.6 7.6 1.4 9.0 5.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1516) MpPF26 PF07666.6 CCF43514.1 - 6.5 6.6 9.1 0.99 9.3 1.2 2.1 1 1 1 2 2 2 0 M penetrans paralogue family 26 DUF2892 PF11127.3 CCF43514.1 - 7.4 6.4 10.8 0.14 11.9 0.8 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2892) DASH_Spc19 PF08287.6 CCF43515.1 - 1.1e-15 57.5 0.9 1.5e-15 57.0 0.6 1.2 1 0 0 1 1 1 1 Spc19 SlyX PF04102.7 CCF43515.1 - 0.041 14.2 0.9 0.14 12.5 0.1 2.0 2 0 0 2 2 2 0 SlyX Surfac_D-trimer PF09006.6 CCF43515.1 - 0.2 11.3 0.6 12 5.7 0.1 2.3 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation Lzipper-MIP1 PF14389.1 CCF43515.1 - 0.53 10.4 4.7 1.2 9.2 1.5 2.1 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Med9 PF07544.8 CCF43515.1 - 0.85 9.3 4.9 9.2 6.0 0.5 2.2 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF972 PF06156.8 CCF43516.1 - 6.5 7.1 10.6 14 6.1 0.8 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Spermine_synth PF01564.12 CCF43517.1 - 2.5e-06 26.6 0.0 5.1e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_23 PF13489.1 CCF43517.1 - 5.1e-05 23.0 0.0 0.00041 20.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF43517.1 - 0.00014 21.8 0.1 0.0003 20.8 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF43517.1 - 0.0093 16.5 0.0 0.017 15.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain NPL4 PF05021.10 CCF43518.1 - 1e-128 428.7 0.0 1.3e-128 428.4 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.10 CCF43518.1 - 8.1e-70 233.1 0.1 1.5e-69 232.3 0.1 1.4 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.3 CCF43518.1 - 0.007 16.6 0.0 0.051 13.8 0.0 2.2 1 1 0 1 1 1 1 Nuclear pore localisation protein NPL4 DUF4451 PF14616.1 CCF43518.1 - 0.076 12.7 0.2 0.16 11.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4451) Sec66 PF09802.4 CCF43519.1 - 4.3e-79 264.3 0.2 5e-79 264.1 0.1 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 DUF3527 PF12043.3 CCF43519.1 - 0.024 14.1 0.7 0.029 13.9 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) DUF4456 PF14644.1 CCF43519.1 - 0.058 12.6 0.5 0.084 12.0 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4456) ORC3_N PF07034.6 CCF43521.1 - 2e-38 132.2 0.8 4e-38 131.2 0.5 1.5 1 1 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus BNIP2 PF12496.3 CCF43522.1 - 2.3 8.4 8.0 2.3 8.3 5.6 1.1 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 FemAB PF02388.11 CCF43522.1 - 3.7 6.1 6.9 4.1 5.9 4.8 1.0 1 0 0 1 1 1 0 FemAB family ADH_N PF08240.7 CCF43523.1 - 1.4e-26 92.3 0.6 1.8e-26 92.0 0.4 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_assoc PF13823.1 CCF43523.1 - 1.9e-06 27.4 0.5 3.4e-06 26.5 0.3 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated Ribosomal_L21e PF01157.13 CCF43523.1 - 0.047 13.4 0.1 0.72 9.6 0.0 2.1 1 1 1 2 2 2 0 Ribosomal protein L21e Peptidase_S8 PF00082.17 CCF43524.1 - 1.7e-37 129.1 9.9 2.2e-37 128.7 6.9 1.1 1 0 0 1 1 1 1 Subtilase family ORMDL PF04061.9 CCF43525.1 - 1.6e-60 202.5 3.5 2.1e-60 202.1 2.4 1.1 1 0 0 1 1 1 1 ORMDL family NUDE_C PF04880.8 CCF43526.1 - 2.3 8.5 9.1 2.8 8.2 6.3 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region DUF3275 PF11679.3 CCF43526.1 - 5.6 6.5 7.6 6.5 6.3 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) zf-MYND PF01753.13 CCF43527.1 - 1.8e-06 27.6 9.4 4.8e-06 26.3 6.5 1.7 1 0 0 1 1 1 1 MYND finger Ecl1 PF12855.2 CCF43527.1 - 0.08 12.2 4.8 0.32 10.3 3.3 2.0 1 0 0 1 1 1 0 Life-span regulatory factor PRELI PF04707.9 CCF43528.1 - 2.7e-19 69.2 0.0 6.9e-16 58.1 0.0 2.2 2 0 0 2 2 2 2 PRELI-like family bPH_2 PF03703.9 CCF43528.1 - 0.045 13.7 0.0 0.096 12.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial PH domain DUF1996 PF09362.5 CCF43532.1 - 2e-21 76.7 0.1 2.5e-21 76.4 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) DUF1996 PF09362.5 CCF43533.1 - 7.7e-17 61.7 0.1 9.2e-17 61.5 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) Ras PF00071.17 CCF43534.1 - 5.1e-47 159.2 0.0 6e-47 159.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF43534.1 - 3.1e-15 56.7 0.0 4.6e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CCF43534.1 - 9.4e-06 24.9 0.0 1.4e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 CCF43534.1 - 0.013 14.7 0.0 0.019 14.1 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.4 CCF43534.1 - 0.031 13.7 0.0 1.2 8.5 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.7 CCF43534.1 - 0.079 12.0 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Chs3p PF12271.3 CCF43535.1 - 4.3e-100 334.4 7.5 5.1e-100 334.2 5.2 1.0 1 0 0 1 1 1 1 Chitin synthase III catalytic subunit Lysis_S PF04971.7 CCF43535.1 - 0.028 14.0 0.0 0.091 12.4 0.0 1.9 1 0 0 1 1 1 0 Lysis protein S MpPF26 PF07666.6 CCF43535.1 - 7.1 6.5 16.1 0.21 11.4 1.9 3.7 3 1 1 4 4 4 0 M penetrans paralogue family 26 Cytochrom_B561 PF03188.11 CCF43536.1 - 6.6e-18 64.8 2.3 6.6e-18 64.8 1.6 2.0 3 0 0 3 3 3 1 Eukaryotic cytochrome b561 DUF4006 PF13179.1 CCF43536.1 - 5.1e-05 22.7 0.1 0.055 13.0 0.1 3.0 2 0 0 2 2 2 2 Family of unknown function (DUF4006) Ni_hydr_CYTB PF01292.15 CCF43536.1 - 0.00097 18.5 11.9 0.021 14.2 2.3 2.5 1 1 1 2 2 2 2 Prokaryotic cytochrome b561 PepSY_TM_1 PF13172.1 CCF43536.1 - 0.0013 18.3 0.3 0.0013 18.3 0.2 3.9 5 0 0 5 5 3 2 PepSY-associated TM helix DUF2162 PF09930.4 CCF43536.1 - 0.0027 16.8 8.2 0.13 11.4 0.2 2.1 2 0 0 2 2 2 2 Predicted transporter (DUF2162) COX15-CtaA PF02628.10 CCF43536.1 - 0.0063 15.4 12.4 0.14 11.0 2.1 2.1 1 1 1 2 2 2 2 Cytochrome oxidase assembly protein DUF420 PF04238.7 CCF43536.1 - 0.0092 15.9 5.9 0.0092 15.9 4.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF420) DUF998 PF06197.8 CCF43536.1 - 0.015 14.6 14.7 0.083 12.2 4.2 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF998) Tmpp129 PF10272.4 CCF43536.1 - 0.027 13.2 0.4 1.6 7.3 0.2 2.1 2 0 0 2 2 2 0 Putative transmembrane protein precursor Cytochrom_B_N PF00033.14 CCF43536.1 - 0.029 13.7 15.3 0.073 12.4 4.3 3.0 1 1 3 4 4 4 0 Cytochrome b(N-terminal)/b6/petB DUF4079 PF13301.1 CCF43536.1 - 0.04 13.9 17.4 0.9 9.5 2.0 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF4079) PepSY_TM_3 PF13706.1 CCF43536.1 - 0.36 10.2 12.8 0.36 10.2 0.3 3.5 3 0 0 3 3 3 0 PepSY-associated TM helix DUF1980 PF09323.5 CCF43536.1 - 0.37 10.5 2.5 0.61 9.7 0.1 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF1980) PepSY_TM_2 PF13703.1 CCF43536.1 - 0.45 10.7 19.2 0.15 12.2 3.4 3.5 2 1 2 4 4 4 0 PepSY-associated TM helix Ferric_reduct PF01794.14 CCF43536.1 - 2 8.4 11.9 1.3 9.1 5.6 2.6 2 1 0 2 2 2 0 Ferric reductase like transmembrane component DUF202 PF02656.10 CCF43536.1 - 3 8.1 5.4 3.5e+02 1.5 3.6 3.4 2 1 0 2 2 2 0 Domain of unknown function (DUF202) DUF2306 PF10067.4 CCF43536.1 - 5.8 7.0 15.8 0.31 11.1 0.3 3.4 2 1 0 3 3 3 0 Predicted membrane protein (DUF2306) DUF4149 PF13664.1 CCF43536.1 - 7.2 6.7 14.5 0.22 11.5 2.5 2.8 1 1 1 2 2 1 0 Domain of unknown function (DUF4149) Allantoicase PF03561.10 CCF43537.1 - 3.9e-107 354.3 0.2 4.3e-57 191.8 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat DIL PF01843.14 CCF43538.1 - 4e-20 71.6 0.6 1.4e-12 47.3 0.1 2.6 2 0 0 2 2 2 2 DIL domain Ank_2 PF12796.2 CCF43538.1 - 4.4e-15 55.7 0.0 1.6e-14 54.0 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 CCF43538.1 - 5.1e-15 54.4 0.0 1.3e-06 27.9 0.0 4.0 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.1 CCF43538.1 - 1.8e-11 43.8 0.0 2e-05 24.7 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 CCF43538.1 - 1e-10 41.8 0.1 6.6e-06 26.4 0.0 4.2 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF43538.1 - 4e-09 35.8 0.1 0.0051 16.9 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Cys_Met_Meta_PP PF01053.15 CCF43539.1 - 5.1e-137 456.2 0.0 6e-137 456.0 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 CCF43539.1 - 7.3e-07 28.4 0.0 1.7e-06 27.2 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_5 PF00266.14 CCF43539.1 - 1e-05 24.5 0.0 2.5e-05 23.2 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class-V Met_gamma_lyase PF06838.6 CCF43539.1 - 1.6e-05 23.4 0.3 4.6e-05 21.8 0.2 1.6 1 1 0 1 1 1 1 Methionine gamma-lyase DegT_DnrJ_EryC1 PF01041.12 CCF43539.1 - 0.00029 19.9 0.1 0.00059 18.9 0.0 1.5 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 CCF43539.1 - 0.011 14.9 0.1 0.039 13.0 0.0 1.8 1 1 0 1 1 1 0 Beta-eliminating lyase ADH_zinc_N PF00107.21 CCF43541.1 - 3.5e-26 91.2 0.1 5.5e-26 90.6 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF43541.1 - 4.4e-19 69.6 0.0 1e-18 68.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF43541.1 - 2e-10 40.3 0.0 5.7e-10 38.9 0.0 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.16 CCF43541.1 - 0.022 14.3 0.1 0.042 13.4 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Smg4_UPF3 PF03467.10 CCF43542.1 - 2.2e-26 92.9 1.4 3e-26 92.4 0.0 2.0 2 0 0 2 2 2 1 Smg-4/UPF3 family RRM_6 PF14259.1 CCF43542.1 - 3.8e-07 29.9 0.0 3.9e-05 23.5 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CCF43542.1 - 1e-06 28.2 0.0 0.00015 21.3 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF43542.1 - 0.00047 19.9 0.0 0.001 18.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NUDIX PF00293.23 CCF43543.1 - 2.6e-10 40.0 0.0 4.9e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain SelB-wing_3 PF09107.6 CCF43543.1 - 0.078 12.3 0.1 0.17 11.2 0.1 1.5 1 0 0 1 1 1 0 Elongation factor SelB, winged helix BCIP PF13862.1 CCF43544.1 - 1.6e-64 216.9 0.1 2.1e-64 216.6 0.1 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein DUF3005 PF11448.3 CCF43544.1 - 0.12 11.9 0.1 2.3 7.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3005) CM_2 PF01817.16 CCF43545.1 - 8.5e-07 28.9 0.1 0.00012 22.0 0.0 3.0 2 1 0 2 2 2 2 Chorismate mutase type II Zn_clus PF00172.13 CCF43546.1 - 0.00046 20.0 1.5 0.00098 18.9 1.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Asp PF00026.18 CCF43548.1 - 5.5e-73 245.9 5.4 6.6e-73 245.7 3.7 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CCF43548.1 - 9.9e-12 45.1 1.8 9.9e-12 45.1 1.2 2.2 3 1 0 3 3 3 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 CCF43548.1 - 1.1e-06 29.0 2.2 0.0061 17.0 0.2 3.9 3 1 0 3 3 3 2 Aspartyl protease TAXi_C PF14541.1 CCF43548.1 - 2.8e-05 23.7 0.1 0.00027 20.5 0.1 2.1 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.1 CCF43548.1 - 0.045 13.5 0.1 0.81 9.5 0.0 2.4 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease K_channel_TID PF07941.6 CCF43548.1 - 0.76 10.0 5.1 2 8.7 3.5 1.7 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain AIG2_2 PF13772.1 CCF43549.1 - 3e-06 27.2 0.0 3.4e-05 23.8 0.0 2.3 2 1 0 2 2 2 1 AIG2-like family AIG2 PF06094.7 CCF43549.1 - 0.0097 16.3 0.0 0.014 15.8 0.0 1.3 1 0 0 1 1 1 1 AIG2-like family GMC_oxred_N PF00732.14 CCF43551.1 - 4.8e-57 193.3 0.0 6.5e-57 192.9 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF43551.1 - 2.8e-37 128.2 0.0 6.2e-37 127.0 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 CCF43551.1 - 4.5e-07 29.1 0.3 0.023 13.5 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF43551.1 - 0.00044 20.2 0.0 0.0014 18.5 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF43551.1 - 0.0018 18.2 0.1 0.28 11.0 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF43551.1 - 0.0018 17.2 0.8 0.036 12.9 0.2 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_3 PF13738.1 CCF43551.1 - 0.016 15.2 0.1 1.5 8.8 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CCF43551.1 - 0.054 12.3 0.3 3.3 6.4 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A DUF3843 PF12954.2 CCF43551.1 - 0.092 11.7 0.4 0.14 11.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3843) Catalase-rel PF06628.7 CCF43551.1 - 0.13 12.1 0.0 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 Catalase-related immune-responsive Myosin_TH1 PF06017.8 CCF43552.1 - 6.2e-14 51.7 0.0 1.2e-13 50.8 0.0 1.5 2 0 0 2 2 2 1 Myosin tail SH3_1 PF00018.23 CCF43552.1 - 7.6e-14 50.8 0.2 1.5e-13 49.8 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 CCF43552.1 - 2.3e-13 49.4 0.1 6.1e-13 48.1 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 CCF43552.1 - 2.9e-10 39.4 0.0 1.8e-09 36.9 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_3 PF08239.6 CCF43552.1 - 0.023 14.8 0.3 0.05 13.8 0.2 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain zf-DHHC PF01529.15 CCF43553.1 - 5.9e-12 45.3 3.7 7.8e-12 44.9 2.6 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase NAD_binding_8 PF13450.1 CCF43554.1 - 7.6e-11 41.8 0.0 8.7e-11 41.6 0.0 1.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF43554.1 - 2.2e-06 27.9 0.0 2.2e-06 27.8 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF43554.1 - 0.00017 20.7 0.0 0.0002 20.5 0.0 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.19 CCF43554.1 - 0.00038 19.4 0.0 0.00038 19.4 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 CCF43554.1 - 0.0022 17.1 0.0 0.0022 17.1 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 CCF43554.1 - 0.0029 16.5 0.0 0.0032 16.4 0.0 1.0 1 0 0 1 1 1 1 Lycopene cyclase protein Amino_oxidase PF01593.19 CCF43554.1 - 0.03 13.3 0.0 0.033 13.2 0.0 1.1 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase FAD_binding_8 PF08022.7 CCF43555.1 - 6.8e-19 67.6 0.0 1.3e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.14 CCF43555.1 - 6.2e-12 45.6 3.2 6.2e-12 45.6 2.2 2.3 1 1 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.7 CCF43555.1 - 9.5e-09 35.3 0.1 1.9e-05 24.6 0.0 3.1 2 1 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_6 PF00970.19 CCF43555.1 - 0.0044 17.1 0.0 0.016 15.2 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain DUF308 PF03729.8 CCF43555.1 - 0.0057 16.6 2.5 0.019 14.9 1.8 1.9 1 0 0 1 1 1 1 Short repeat of unknown function (DUF308) EF-hand_7 PF13499.1 CCF43555.1 - 0.056 13.5 0.2 0.16 12.1 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.1 CCF43555.1 - 0.07 12.7 0.4 0.15 11.7 0.3 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 CCF43555.1 - 0.12 12.3 0.4 0.33 10.9 0.3 1.7 1 0 0 1 1 1 0 EF-hand domain COesterase PF00135.23 CCF43556.1 - 1.2e-89 301.4 0.0 1.5e-89 301.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF43556.1 - 1.4e-06 28.0 0.1 3.6e-06 26.7 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold 7TM_GPCR_Str PF10326.4 CCF43558.1 - 0.62 9.1 5.6 0.66 9.0 3.9 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Str DUF3455 PF11937.3 CCF43559.1 - 3.6e-36 124.7 0.0 4.6e-36 124.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) Tyrosinase PF00264.15 CCF43561.1 - 3.2e-45 155.0 0.0 5e-45 154.3 0.0 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase AlgF PF11182.3 CCF43562.1 - 0.0027 17.4 0.1 0.12 11.9 0.0 2.6 2 1 1 3 3 3 1 Alginate O-acetyl transferase AlgF Gly-zipper_OmpA PF13436.1 CCF43562.1 - 0.023 14.3 6.1 0.069 12.8 4.2 1.8 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain MAS20 PF02064.10 CCF43562.1 - 0.078 12.8 0.1 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 MAS20 protein import receptor DUF410 PF04190.8 CCF43563.1 - 1.3e-29 103.5 0.0 1.4e-29 103.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF410) Glyco_hydro_61 PF03443.9 CCF43564.1 - 1.8e-07 31.1 0.1 3.2e-07 30.4 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 61 Sugar_tr PF00083.19 CCF43566.1 - 8.5e-44 149.8 15.4 1e-43 149.5 10.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF43566.1 - 9.7e-07 27.8 24.0 4.1e-06 25.7 17.0 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily ABC2_membrane_5 PF13346.1 CCF43566.1 - 0.018 14.3 12.4 0.011 14.9 6.9 1.8 2 0 0 2 2 2 0 ABC-2 family transporter protein Amastin PF07344.6 CCF43566.1 - 1.7 8.2 11.7 2.3 7.7 4.9 2.4 1 1 1 2 2 2 0 Amastin surface glycoprotein DUF4131 PF13567.1 CCF43566.1 - 5.3 6.4 10.6 7 6.0 3.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) ADH_zinc_N PF00107.21 CCF43567.1 - 1e-14 54.1 0.0 1.9e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF43567.1 - 1.1e-07 31.6 2.5 6.9e-07 29.0 0.9 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 CCF43567.1 - 2.6e-07 31.5 0.0 4.6e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Cbl_N3 PF02762.9 CCF43567.1 - 0.044 13.4 0.1 0.2 11.3 0.0 2.1 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, SH2-like domain Dynamin_N PF00350.18 CCF43568.1 - 4.6e-13 49.3 3.9 2.5e-12 46.9 0.0 3.6 3 1 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.18 CCF43568.1 - 1.7e-05 24.7 0.1 0.0018 18.2 0.1 3.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CCF43568.1 - 0.0002 21.8 0.0 0.001 19.5 0.0 2.3 1 0 0 1 1 1 1 Miro-like protein ABC_tran PF00005.22 CCF43568.1 - 0.00072 19.8 1.5 0.0028 17.9 0.0 2.6 2 1 0 2 2 2 1 ABC transporter AAA_16 PF13191.1 CCF43568.1 - 0.0017 18.4 0.5 0.25 11.3 0.0 3.6 3 0 0 3 3 3 1 AAA ATPase domain DUF258 PF03193.11 CCF43568.1 - 0.015 14.5 0.0 0.046 12.8 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 CCF43568.1 - 0.02 14.4 0.0 0.043 13.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.1 CCF43568.1 - 0.028 14.5 1.0 2.6 8.2 0.0 3.7 5 0 0 5 5 5 0 AAA domain Prefoldin PF02996.12 CCF43568.1 - 0.088 12.4 11.7 0.96 9.1 0.1 3.5 3 0 0 3 3 3 0 Prefoldin subunit PEP-utilisers_N PF05524.8 CCF43568.1 - 0.61 9.8 7.8 3.2 7.5 0.1 4.7 5 0 0 5 5 5 0 PEP-utilising enzyme, N-terminal DUF87 PF01935.12 CCF43568.1 - 9.2 6.0 12.7 1.2 8.9 0.0 3.9 3 1 1 4 4 4 0 Domain of unknown function DUF87 NUDIX_2 PF13869.1 CCF43569.1 - 7.5e-82 273.2 0.0 8.9e-82 272.9 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase UPF0047 PF01894.12 CCF43570.1 - 5.5e-41 139.0 0.0 6.3e-41 138.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 2OG-Fe_Oxy_2 PF10014.4 CCF43571.1 - 0.27 10.5 4.8 0.09 12.1 0.4 2.1 1 1 1 2 2 2 0 2OG-Fe dioxygenase Abhydrolase_2 PF02230.11 CCF43572.1 - 0.0001 21.8 0.0 0.00029 20.3 0.0 1.6 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 CCF43572.1 - 0.0023 17.6 0.0 0.0025 17.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family GAS2 PF02187.12 CCF43572.1 - 0.1 12.3 0.5 0.81 9.4 0.1 2.0 2 0 0 2 2 2 0 Growth-Arrest-Specific Protein 2 Domain HEAT PF02985.17 CCF43573.1 - 1.3e-18 65.3 0.1 0.062 13.4 0.0 5.2 5 0 0 5 5 5 5 HEAT repeat HEAT_2 PF13646.1 CCF43573.1 - 3.1e-09 36.9 0.0 0.0024 18.1 0.0 3.1 1 1 1 2 2 2 2 HEAT repeats Vac14_Fab1_bd PF12755.2 CCF43573.1 - 0.036 14.4 0.0 4.5 7.7 0.0 3.0 2 1 0 3 3 3 0 Vacuolar 14 Fab1-binding region MadL PF03817.8 CCF43573.1 - 0.04 13.7 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 Malonate transporter MadL subunit HEAT_EZ PF13513.1 CCF43573.1 - 0.042 14.3 0.1 6.6 7.3 0.0 3.4 3 1 1 4 4 4 0 HEAT-like repeat Methyltransf_18 PF12847.2 CCF43574.1 - 3.2e-18 66.3 0.0 5.5e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF43574.1 - 5.1e-13 48.8 0.0 2.4e-08 33.7 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_26 PF13659.1 CCF43574.1 - 2.6e-09 37.1 0.0 6.3e-09 35.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF43574.1 - 4.3e-08 33.0 0.2 4.2e-07 29.8 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF43574.1 - 5.6e-07 29.9 0.0 2.8e-06 27.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF43574.1 - 2.4e-05 24.7 0.7 0.0002 21.7 0.0 2.4 3 0 0 3 3 2 1 Methyltransferase domain AdoMet_MTase PF07757.8 CCF43574.1 - 5.4e-05 23.2 0.0 0.00013 22.0 0.0 1.7 2 0 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase Methyltransf_25 PF13649.1 CCF43574.1 - 0.00025 21.3 0.0 0.00054 20.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 CCF43574.1 - 0.00057 19.5 0.0 0.00079 19.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF43574.1 - 0.0057 16.0 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.7 CCF43574.1 - 0.011 15.1 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW PrmA PF06325.8 CCF43574.1 - 0.036 13.2 0.0 0.051 12.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.12 CCF43574.1 - 0.058 12.4 0.0 0.087 11.8 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase DUF4632 PF15451.1 CCF43574.1 - 0.12 12.3 2.9 0.33 10.9 2.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) FtsJ PF01728.14 CCF43574.1 - 0.13 12.2 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase PBCV_basic_adap PF08789.5 CCF43574.1 - 0.2 11.3 0.3 0.36 10.5 0.2 1.4 1 0 0 1 1 1 0 PBCV-specific basic adaptor domain p450 PF00067.17 CCF43576.1 - 5.1e-61 206.6 0.0 5.8e-61 206.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Zw10 PF06248.8 CCF43579.1 - 0.03 12.4 0.5 0.03 12.5 0.3 1.0 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 DUF1151 PF06625.6 CCF43579.1 - 0.068 12.8 1.1 0.076 12.7 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1151) TMPIT PF07851.8 CCF43579.1 - 0.35 9.8 2.0 0.36 9.8 1.4 1.0 1 0 0 1 1 1 0 TMPIT-like protein DUF2951 PF11166.3 CCF43579.1 - 0.37 10.6 3.0 0.41 10.5 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) HEAT PF02985.17 CCF43582.1 - 0.00074 19.3 1.0 4 7.7 0.1 4.0 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.1 CCF43582.1 - 0.03 14.6 1.1 6.8 7.0 0.0 2.9 3 0 0 3 3 3 0 HEAT repeats HEAT_EZ PF13513.1 CCF43582.1 - 1 9.9 3.6 8.8 6.9 0.1 4.0 4 0 0 4 4 4 0 HEAT-like repeat Condensation PF00668.15 CCF43584.1 - 1.4e-09 37.2 0.1 1.6e-09 37.0 0.1 1.1 1 0 0 1 1 1 1 Condensation domain Metallophos_2 PF12850.2 CCF43585.1 - 2.6e-07 30.5 0.0 1.3e-06 28.3 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 CCF43585.1 - 4.1e-06 26.3 0.0 7.1e-06 25.5 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase PITH PF06201.8 CCF43588.1 - 1.7e-40 138.2 0.0 2.3e-40 137.8 0.0 1.2 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.15 CCF43588.1 - 2.4e-28 97.8 0.1 3.7e-28 97.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 CCF43588.1 - 1.7e-07 31.2 0.0 6.4e-05 22.9 0.0 2.6 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.1 CCF43588.1 - 2.4e-06 27.7 0.1 8.1e-06 26.0 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 CCF43588.1 - 0.0011 18.9 0.0 0.0068 16.4 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.16 CCF43588.1 - 0.0055 16.3 0.0 0.024 14.3 0.0 2.0 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_9 PF14595.1 CCF43588.1 - 0.058 12.9 0.0 0.098 12.2 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin HyaE PF07449.6 CCF43588.1 - 0.1 12.4 0.0 0.3 11.0 0.0 1.7 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Spt5_N PF11942.3 CCF43590.1 - 0.66 10.6 14.5 1.2 9.8 10.1 1.4 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal CENP-B_dimeris PF09026.5 CCF43590.1 - 1.9 8.7 14.8 3 8.1 10.3 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sigma70_ner PF04546.8 CCF43590.1 - 3.1 7.3 9.0 4.4 6.8 6.2 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region GMC_oxred_N PF00732.14 CCF43591.1 - 1.7e-44 152.1 0.0 2.2e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF43591.1 - 9.3e-33 113.5 0.1 1.5e-32 112.8 0.1 1.3 1 0 0 1 1 1 1 GMC oxidoreductase ADH_zinc_N PF00107.21 CCF43594.1 - 2.3e-34 117.7 1.8 3.2e-34 117.2 1.3 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF43594.1 - 1.5e-12 48.5 0.1 3.2e-12 47.4 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF43594.1 - 1.6e-07 31.0 0.0 4e-07 29.7 0.0 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.13 CCF43594.1 - 0.0039 17.1 0.3 0.0079 16.1 0.2 1.5 1 0 0 1 1 1 1 TrkA-N domain AlaDh_PNT_C PF01262.16 CCF43594.1 - 0.033 13.7 3.6 0.077 12.5 1.4 1.9 1 1 1 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain CN_hydrolase PF00795.17 CCF43595.1 - 3e-12 46.2 0.0 4.6e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF1212 PF06738.7 CCF43597.1 - 3.5e-23 82.0 0.0 4.9e-23 81.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1212) EAP30 PF04157.11 CCF43597.1 - 0.031 13.4 0.1 0.098 11.8 0.0 1.7 2 0 0 2 2 2 0 EAP30/Vps36 family AIF_C PF14721.1 CCF43597.1 - 0.037 14.2 1.0 0.16 12.2 0.7 2.0 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Acyl-CoA_dh_M PF02770.14 CCF43597.1 - 0.49 9.9 2.4 1.5 8.4 1.7 1.8 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, middle domain Zn_clus PF00172.13 CCF43599.1 - 5.5e-06 26.1 7.9 9.1e-06 25.4 5.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HTH_psq PF05225.11 CCF43600.1 - 0.057 12.9 0.0 0.092 12.3 0.0 1.3 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF43600.1 - 0.09 12.6 0.0 0.54 10.1 0.0 2.2 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain NB-ARC PF00931.17 CCF43601.1 - 3e-06 26.3 0.0 5.9e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain PNP_UDP_1 PF01048.15 CCF43601.1 - 4.5e-05 22.5 0.1 0.00018 20.5 0.1 1.9 1 1 0 1 1 1 1 Phosphorylase superfamily Cep57_CLD_2 PF14197.1 CCF43605.1 - 0.02 14.8 1.7 0.02 14.8 1.2 9.2 6 2 2 8 8 8 0 Centrosome localisation domain of PPC89 DUF1843 PF08898.5 CCF43605.1 - 9.9 6.2 13.3 8.1 6.5 0.4 5.4 4 0 0 4 4 4 0 Domain of unknown function (DUF1843) DEAD PF00270.24 CCF43606.1 - 1.2e-41 142.0 0.0 4.8e-41 140.0 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF43606.1 - 2.7e-22 78.3 0.0 5.9e-22 77.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 CCF43606.1 - 3.4e-05 22.8 0.0 6.1e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF1253 PF06862.7 CCF43606.1 - 0.29 9.5 1.7 5.4 5.3 0.0 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1253) BBE PF08031.7 CCF43607.1 - 3e-11 43.0 0.0 4.1e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Berberine and berberine like M20_dimer PF07687.9 CCF43608.1 - 5.9e-19 67.8 0.1 1e-18 67.1 0.1 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.23 CCF43608.1 - 2.4e-18 66.3 3.2 3.9e-18 65.6 2.2 1.3 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.12 CCF43608.1 - 0.0068 16.1 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 IF-2B PF01008.12 CCF43609.1 - 1.5e-63 214.4 0.5 1.9e-63 214.1 0.3 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DNA_gyraseB PF00204.20 CCF43611.1 - 0.091 11.9 0.0 0.099 11.8 0.0 1.1 1 0 0 1 1 1 0 DNA gyrase B p450 PF00067.17 CCF43613.1 - 4.9e-43 147.3 0.0 1.4e-27 96.3 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Ank_2 PF12796.2 CCF43614.1 - 8.7e-27 93.3 0.0 8.9e-10 38.7 0.0 5.2 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 CCF43614.1 - 8.8e-17 59.9 1.7 4.2e-06 26.3 0.0 8.2 8 1 0 8 8 8 2 Ankyrin repeat Ank_3 PF13606.1 CCF43614.1 - 1.5e-13 49.5 1.0 0.0008 19.4 0.0 8.9 9 1 1 10 10 10 2 Ankyrin repeat Ank_4 PF13637.1 CCF43614.1 - 3.2e-10 40.2 0.2 0.001 19.5 0.0 6.2 4 1 1 5 5 5 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF43614.1 - 5.5e-10 39.1 0.9 6.6e-08 32.5 0.0 4.3 5 0 0 5 5 5 1 Ankyrin repeats (many copies) Phage_Gp23 PF10669.4 CCF43614.1 - 0.89 9.6 7.6 0.18 11.8 0.3 2.6 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) Lge1 PF11488.3 CCF43614.1 - 1.3 9.3 4.8 3.4 7.9 0.6 2.9 3 0 0 3 3 3 0 Transcriptional regulatory protein LGE1 GMC_oxred_C PF05199.8 CCF43616.1 - 8.6e-06 26.1 0.0 3e-05 24.3 0.0 1.9 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.14 CCF43616.1 - 1.2e-05 24.6 0.0 0.0013 17.9 0.0 2.5 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.19 CCF43616.1 - 5.7e-05 22.1 0.1 0.00012 21.1 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 CCF43616.1 - 0.002 17.2 0.1 0.0032 16.6 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF43616.1 - 0.0022 17.8 0.1 0.0051 16.7 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF43616.1 - 0.0037 16.2 0.3 0.03 13.2 0.2 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF43616.1 - 0.0042 17.0 0.2 0.014 15.4 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 CCF43616.1 - 0.019 15.3 0.4 0.091 13.1 0.0 2.4 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF43616.1 - 0.027 12.9 0.1 0.044 12.2 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein GIDA PF01134.17 CCF43616.1 - 0.039 12.7 0.6 0.062 12.1 0.4 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Thi4 PF01946.12 CCF43616.1 - 0.066 12.2 0.0 0.19 10.7 0.0 1.7 2 0 0 2 2 2 0 Thi4 family HATPase_c PF02518.21 CCF43618.1 - 2.2e-24 85.2 0.2 4.5e-24 84.3 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 CCF43618.1 - 3.1e-23 81.9 0.2 5.9e-22 77.7 0.0 2.8 3 0 0 3 3 3 1 Response regulator receiver domain HisKA PF00512.20 CCF43618.1 - 1.4e-21 76.2 0.4 8e-21 73.8 0.1 2.6 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.6 CCF43618.1 - 5.6e-21 74.4 1.1 1.7e-11 44.0 0.2 3.6 3 0 0 3 3 3 3 PAS fold PAS_9 PF13426.1 CCF43618.1 - 3.4e-15 56.2 0.0 4.5e-07 30.2 0.0 3.5 2 1 0 2 2 2 2 PAS domain PAS_4 PF08448.5 CCF43618.1 - 1.3e-08 34.7 0.2 3.6e-06 26.9 0.0 3.2 3 0 0 3 3 3 1 PAS fold PAS PF00989.19 CCF43618.1 - 1.5e-08 34.4 0.0 0.0069 16.1 0.0 2.7 2 0 0 2 2 2 2 PAS fold UPF0565 PF10561.4 CCF43618.1 - 0.056 12.3 0.0 0.097 11.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 PAS_8 PF13188.1 CCF43618.1 - 0.087 12.7 0.0 3.1 7.7 0.0 2.6 2 0 0 2 2 2 0 PAS domain PAS_10 PF13596.1 CCF43618.1 - 0.096 12.9 0.0 0.31 11.3 0.0 1.9 1 0 0 1 1 1 0 PAS domain Cpn60_TCP1 PF00118.19 CCF43620.1 - 1.6e-160 534.9 0.0 1.8e-160 534.7 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DAHP_synth_2 PF01474.11 CCF43621.1 - 1.9e-52 178.1 0.0 2.3e-52 177.8 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family HHH_8 PF14716.1 CCF43622.1 - 0.14 12.3 2.0 0.15 12.2 0.5 1.7 2 0 0 2 2 2 0 Helix-hairpin-helix domain Lectin_leg-like PF03388.8 CCF43623.1 - 6.2e-15 54.9 0.0 1.1e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 Legume-like lectin family Baculo_PEP_C PF04513.7 CCF43623.1 - 0.0074 16.1 0.8 0.015 15.1 0.5 1.4 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2408 PF10303.4 CCF43623.1 - 0.009 16.1 0.6 0.009 16.1 0.4 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2408) DUF4592 PF15262.1 CCF43623.1 - 0.013 16.0 4.4 0.024 15.1 3.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4592) ATG16 PF08614.6 CCF43623.1 - 0.23 11.2 13.4 0.38 10.5 9.3 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Pex16 PF08610.5 CCF43623.1 - 1.4 7.8 5.5 2.1 7.2 3.8 1.2 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) TMF_DNA_bd PF12329.3 CCF43623.1 - 1.5 8.6 11.1 0.052 13.3 1.0 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Helicase_C PF00271.26 CCF43625.1 - 9.3e-27 92.7 0.2 5.2e-26 90.3 0.1 2.2 1 1 1 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 CCF43625.1 - 2e-18 66.4 0.0 1.9e-17 63.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase SNF2_N PF00176.18 CCF43625.1 - 0.0016 17.3 0.0 0.0023 16.8 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain SAD_SRA PF02182.12 CCF43626.1 - 3.9e-06 26.2 0.2 5.6e-06 25.7 0.1 1.3 1 0 0 1 1 1 1 SAD/SRA domain PMT PF02366.13 CCF43627.1 - 3.4e-76 255.8 15.7 3.4e-76 255.8 10.9 1.9 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 CCF43627.1 - 5.1e-54 182.7 0.0 8.7e-54 181.9 0.0 1.4 1 0 0 1 1 1 1 MIR domain Polysacc_deac_1 PF01522.16 CCF43628.1 - 3.4e-29 100.9 0.0 7.7e-29 99.8 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 CCF43628.1 - 0.0018 17.2 0.0 0.0029 16.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 ERG4_ERG24 PF01222.12 CCF43629.1 - 6.6e-140 466.4 17.5 7.7e-140 466.2 12.1 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Glyco_hydro_18 PF00704.23 CCF43630.1 - 3.1e-88 296.5 0.6 3.6e-88 296.3 0.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_2_C PF02836.12 CCF43631.1 - 2.5e-100 335.2 0.0 3.2e-100 334.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.13 CCF43631.1 - 6.8e-49 165.6 0.2 1.3e-48 164.6 0.2 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.16 CCF43631.1 - 8.7e-16 58.3 0.2 2.2e-15 57.0 0.1 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Bgal_small_N PF02929.12 CCF43631.1 - 5.6e-06 25.5 0.0 1.2e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Beta galactosidase small chain tRNA-synt_2b PF00587.20 CCF43633.1 - 2.1e-21 76.2 0.0 3.1e-21 75.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 CCF43633.1 - 7e-12 45.3 7.1 1.8e-11 43.9 4.9 1.7 1 1 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Atg14 PF10186.4 CCF43633.1 - 0.073 11.9 7.9 0.11 11.4 5.4 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF342 PF03961.8 CCF43633.1 - 0.12 10.7 0.9 0.17 10.2 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Mnd1 PF03962.10 CCF43633.1 - 0.12 11.9 3.2 0.21 11.2 2.2 1.2 1 0 0 1 1 1 0 Mnd1 family tRNA-synt_His PF13393.1 CCF43633.1 - 0.15 11.0 1.2 0.29 10.1 0.0 1.9 2 0 0 2 2 2 0 Histidyl-tRNA synthetase RRM_1 PF00076.17 CCF43635.1 - 5.8e-46 153.9 0.0 1.6e-16 59.7 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF43635.1 - 6.7e-25 86.8 0.0 6.2e-10 38.9 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF43635.1 - 7.5e-21 73.7 0.0 1.3e-08 34.5 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 CCF43635.1 - 1.8e-05 24.5 0.0 0.00015 21.5 0.0 2.3 3 0 0 3 3 3 1 RNA binding motif Nup35_RRM_2 PF14605.1 CCF43635.1 - 7.9e-05 22.3 0.1 0.0034 17.1 0.0 2.9 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Cyt-b5 PF00173.23 CCF43636.1 - 9.8e-15 54.1 0.1 1.1e-14 53.9 0.1 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain RE_LlaJI PF09563.5 CCF43636.1 - 0.11 11.1 0.0 0.13 10.9 0.0 1.0 1 0 0 1 1 1 0 LlaJI restriction endonuclease Acetyltransf_1 PF00583.19 CCF43637.1 - 2.6e-08 33.7 0.0 4.6e-08 32.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF43637.1 - 4.4e-07 29.9 0.0 6.9e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 CCF43637.1 - 0.0011 18.8 0.0 0.013 15.3 0.0 2.2 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF43637.1 - 0.016 14.9 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_10 PF13673.1 CCF43637.1 - 0.023 14.7 0.0 0.047 13.8 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain GxGYxYP PF14323.1 CCF43637.1 - 0.068 11.8 0.0 0.084 11.5 0.0 1.1 1 0 0 1 1 1 0 GxGYxY sequence motif in domain of unknown function Acetyltransf_CG PF14542.1 CCF43637.1 - 0.073 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase zf-FCS PF06467.9 CCF43638.1 - 0.027 14.1 2.6 0.54 9.9 0.0 2.3 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Zn_ribbon_recom PF13408.1 CCF43638.1 - 0.072 13.3 7.0 0.85 9.9 1.3 2.3 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-ribbon_3 PF13248.1 CCF43638.1 - 0.11 11.7 0.3 0.11 11.7 0.2 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zf-like PF04071.7 CCF43638.1 - 0.25 11.0 5.7 0.47 10.1 4.0 1.5 1 1 0 1 1 1 0 Cysteine-rich small domain CBM_10 PF02013.11 CCF43638.1 - 0.42 10.9 0.4 0.42 10.9 0.3 2.5 3 0 0 3 3 3 0 Cellulose or protein binding domain PHD PF00628.24 CCF43638.1 - 0.82 9.4 7.2 1.4 8.6 0.9 2.3 2 0 0 2 2 2 0 PHD-finger zinc_ribbon_4 PF13717.1 CCF43638.1 - 2.5 7.8 7.7 3.4 7.4 0.7 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 CCF43638.1 - 2.8 7.6 7.6 4.4 6.9 0.7 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Prok-RING_1 PF14446.1 CCF43638.1 - 3 7.6 7.1 1.5 8.6 0.3 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 Desulfoferrod_N PF06397.7 CCF43638.1 - 3.4 7.1 7.2 7.1 6.1 1.2 2.3 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain DZR PF12773.2 CCF43638.1 - 4.5 7.1 10.9 2.1 8.2 1.0 2.2 1 1 1 2 2 2 0 Double zinc ribbon zf-RING_3 PF14369.1 CCF43638.1 - 8.9 6.4 8.4 3.2 7.8 0.6 2.4 2 0 0 2 2 2 0 zinc-finger DUF164 PF02591.10 CCF43638.1 - 9 6.2 9.8 9.3 6.1 0.3 2.9 3 0 0 3 3 3 0 Putative zinc ribbon domain Homeobox PF00046.24 CCF43639.1 - 4.1e-15 55.1 0.7 8.7e-15 54.0 0.5 1.6 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 CCF43639.1 - 0.018 14.7 0.0 0.044 13.4 0.0 1.7 1 0 0 1 1 1 0 Homeobox KN domain Mac PF12464.3 CCF43639.1 - 0.06 13.3 0.6 0.46 10.5 0.4 2.2 1 1 0 1 1 1 0 Maltose acetyltransferase TFIIA PF03153.8 CCF43639.1 - 3.5 7.4 22.5 5.3 6.8 15.6 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SLX9 PF15341.1 CCF43641.1 - 3.9e-39 133.8 2.6 4.7e-39 133.5 1.8 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 KGG PF10685.4 CCF43642.1 - 2.9e-10 39.8 2.8 3.5e-10 39.5 0.1 2.2 2 0 0 2 2 2 1 Stress-induced bacterial acidophilic repeat motif RNA_pol_A_bac PF01000.21 CCF43643.1 - 5.7e-28 97.3 0.0 1.1e-27 96.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 CCF43643.1 - 7.2e-14 50.6 0.0 1.3e-13 49.8 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Phage_1_1 PF08200.6 CCF43643.1 - 0.14 12.3 0.1 0.29 11.3 0.1 1.4 1 0 0 1 1 1 0 Bacteriophage 1.1 Protein ThiF PF00899.16 CCF43644.1 - 4.4e-36 123.6 0.6 9.8e-36 122.5 0.1 1.7 2 0 0 2 2 2 1 ThiF family E2_bind PF08825.5 CCF43644.1 - 4.2e-28 96.9 0.5 8.4e-28 95.9 0.3 1.5 1 0 0 1 1 1 1 E2 binding domain UBACT PF02134.16 CCF43644.1 - 2.2e-24 84.8 2.5 2.9e-24 84.4 0.8 1.9 2 0 0 2 2 2 1 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 CCF43644.1 - 3.1e-15 55.2 2.6 3.1e-15 55.2 1.8 2.1 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site UAE_UbL PF14732.1 CCF43644.1 - 0.012 15.7 0.3 0.11 12.6 0.1 2.4 2 0 0 2 2 2 0 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Telomere_reg-2 PF10193.4 CCF43645.1 - 1.1e-39 135.2 0.0 3.5e-39 133.5 0.0 1.9 1 0 0 1 1 1 1 Telomere length regulation protein Nuf2 PF03800.9 CCF43647.1 - 1.1e-45 155.2 0.0 1.8e-45 154.5 0.0 1.3 1 0 0 1 1 1 1 Nuf2 family BLOC1_2 PF10046.4 CCF43647.1 - 0.065 13.3 4.5 0.1 12.7 3.2 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Vg_Tdu PF07545.9 CCF43647.1 - 0.068 12.6 0.2 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 Vestigial/Tondu family Snapin_Pallidin PF14712.1 CCF43647.1 - 0.12 12.6 5.4 1.6 9.0 0.1 2.3 2 0 0 2 2 2 0 Snapin/Pallidin DivIC PF04977.10 CCF43647.1 - 0.15 11.5 8.9 0.17 11.3 3.9 2.1 1 1 1 2 2 2 0 Septum formation initiator DUF641 PF04859.7 CCF43647.1 - 0.2 11.4 7.0 0.31 10.7 4.9 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Prefoldin_2 PF01920.15 CCF43647.1 - 0.23 11.2 10.1 0.32 10.7 0.5 2.7 2 1 1 3 3 3 0 Prefoldin subunit V_ATPase_I PF01496.14 CCF43647.1 - 0.29 8.9 4.1 0.36 8.6 2.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF972 PF06156.8 CCF43647.1 - 0.31 11.3 5.1 0.61 10.4 3.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Seryl_tRNA_N PF02403.17 CCF43647.1 - 0.32 11.0 8.2 0.52 10.3 5.7 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Nup54 PF13874.1 CCF43647.1 - 0.64 9.6 12.7 3.4 7.3 8.7 1.9 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 CENP-Q PF13094.1 CCF43647.1 - 0.86 9.6 11.2 1.4 8.9 7.8 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit APG6 PF04111.7 CCF43647.1 - 0.98 8.3 9.1 1.4 7.8 6.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF2175 PF09943.4 CCF43647.1 - 1.2 9.2 3.7 1.9 8.5 2.6 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) IncA PF04156.9 CCF43647.1 - 1.9 8.0 9.4 2.8 7.5 6.5 1.2 1 0 0 1 1 1 0 IncA protein Atg14 PF10186.4 CCF43647.1 - 4.7 6.0 8.2 7.5 5.3 5.7 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 APC_CDC26 PF10471.4 CCF43651.1 - 5.1e-06 27.1 47.0 0.17 12.6 28.6 4.0 1 1 1 2 2 2 2 Anaphase-promoting complex APC subunit 1 PAT1 PF09770.4 CCF43651.1 - 1.8 6.7 39.5 2.1 6.4 27.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 CCF43651.1 - 2.4 7.9 26.4 2.9 7.7 18.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cwf_Cwc_15 PF04889.7 CCF43651.1 - 3.6 7.2 17.3 4.8 6.8 12.0 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein HlyD_2 PF12700.2 CCF43651.1 - 5.2 6.1 11.0 6.1 5.8 7.6 1.2 1 0 0 1 1 1 0 HlyD family secretion protein MFS_1 PF07690.11 CCF43655.1 - 1.4e-23 83.2 18.3 1.4e-23 83.2 12.7 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily CopD PF05425.8 CCF43655.1 - 6.3 7.0 14.0 0.56 10.4 3.6 3.0 3 0 0 3 3 3 0 Copper resistance protein D zf-HIT PF04438.11 CCF43657.1 - 1.1e-07 31.3 10.9 1.5e-07 30.9 7.6 1.2 1 0 0 1 1 1 1 HIT zinc finger zf-MYND PF01753.13 CCF43657.1 - 0.0043 16.8 5.5 0.0069 16.2 3.8 1.3 1 0 0 1 1 1 1 MYND finger zf-B_box PF00643.19 CCF43657.1 - 0.13 12.1 5.9 0.21 11.5 4.1 1.2 1 0 0 1 1 1 0 B-box zinc finger NUC173 PF08161.7 CCF43659.1 - 2.1e-79 265.5 0.7 2.2e-77 258.8 0.1 3.2 3 0 0 3 3 3 2 NUC173 domain HEAT PF02985.17 CCF43659.1 - 0.12 12.4 1.8 2.1 8.6 0.0 3.7 4 0 0 4 4 4 0 HEAT repeat V-SNARE PF05008.10 CCF43660.1 - 1.9e-20 72.8 2.0 1.9e-20 72.8 1.4 1.8 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.3 CCF43660.1 - 2.1e-20 72.5 2.3 2.1e-20 72.5 1.6 2.1 2 0 0 2 2 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 CCF43660.1 - 0.0046 16.6 1.0 0.0099 15.5 0.1 2.1 2 2 0 2 2 2 1 Sec20 Fusion_gly PF00523.13 CCF43660.1 - 0.029 12.4 1.0 0.37 8.7 0.2 2.1 2 0 0 2 2 2 0 Fusion glycoprotein F0 Myosin_tail_1 PF01576.14 CCF43660.1 - 0.048 11.3 8.6 0.34 8.5 0.5 2.1 2 0 0 2 2 2 0 Myosin tail Spectrin PF00435.16 CCF43660.1 - 0.054 13.7 3.5 0.17 12.2 0.2 2.6 1 1 2 3 3 3 0 Spectrin repeat YvbH_ext PF11724.3 CCF43660.1 - 0.12 12.0 0.0 0.28 10.9 0.0 1.7 1 1 0 1 1 1 0 YvbH-like oligomerisation region YqjK PF13997.1 CCF43660.1 - 0.24 11.5 1.3 5.9 7.1 0.1 2.7 3 0 0 3 3 3 0 YqjK-like protein Spc7 PF08317.6 CCF43660.1 - 1.3 7.5 5.1 5 5.6 0.5 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein Use1 PF09753.4 CCF43660.1 - 1.4 8.2 6.0 11 5.3 4.2 2.4 1 1 0 1 1 1 0 Membrane fusion protein Use1 OppC_N PF12911.2 CCF43660.1 - 2.8 7.4 5.3 0.51 9.7 1.1 1.6 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C NAD_binding_8 PF13450.1 CCF43661.1 - 1.7e-09 37.5 0.1 2e-09 37.3 0.1 1.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF43661.1 - 0.00011 22.3 0.0 0.00012 22.1 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF43661.1 - 0.00011 21.1 0.1 0.00011 21.1 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF43661.1 - 0.00012 21.9 0.0 0.00013 21.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 CCF43661.1 - 0.00063 18.9 0.0 0.00069 18.8 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase GIDA PF01134.17 CCF43661.1 - 0.0087 14.9 0.1 0.0092 14.8 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.2 CCF43661.1 - 0.0096 15.0 0.0 0.0096 15.0 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 CCF43661.1 - 0.01 14.9 0.0 0.012 14.7 0.0 1.1 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.19 CCF43661.1 - 0.019 13.8 0.0 0.021 13.6 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain NAD_Gly3P_dh_N PF01210.18 CCF43661.1 - 0.057 13.1 0.2 0.062 13.0 0.1 1.1 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus HI0933_like PF03486.9 CCF43661.1 - 0.066 11.6 0.0 0.081 11.3 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein AlaDh_PNT_C PF01262.16 CCF43661.1 - 0.12 11.8 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.22 CCF43661.1 - 0.14 12.6 0.0 0.18 12.1 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF1297 PF06973.7 CCF43661.1 - 0.14 11.4 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1297) ApbA PF02558.11 CCF43661.1 - 0.14 11.5 0.2 0.18 11.2 0.1 1.3 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Histone PF00125.19 CCF43662.1 - 8.3e-26 89.9 0.0 1.1e-25 89.5 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 CCF43662.1 - 1.2e-05 25.2 0.0 1.7e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Complex1_LYR PF05347.10 CCF43663.1 - 3e-09 36.5 3.1 4.1e-09 36.1 2.2 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 CCF43663.1 - 3.8e-06 27.0 1.7 5.8e-06 26.4 1.2 1.3 1 0 0 1 1 1 1 Complex1_LYR-like DIOX_N PF14226.1 CCF43664.1 - 8.4e-22 77.8 0.0 1.4e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 CCF43664.1 - 3.1e-19 69.0 0.0 5.1e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Methyltransf_12 PF08242.7 CCF43668.1 - 5.7e-06 26.7 0.0 9.1e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF43668.1 - 0.00013 21.9 0.0 0.00016 21.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF43668.1 - 0.00023 21.7 0.0 0.00038 21.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF43668.1 - 0.00048 20.5 0.0 0.00084 19.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF43668.1 - 0.0078 16.5 0.0 0.013 15.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MFS_1 PF07690.11 CCF43669.1 - 4.8e-38 130.7 23.7 6.5e-38 130.3 16.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF43669.1 - 4e-13 48.7 10.6 5.6e-13 48.2 7.4 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter SPC25 PF06703.6 CCF43669.1 - 0.021 14.3 0.7 0.039 13.5 0.5 1.4 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) ketoacyl-synt PF00109.21 CCF43671.1 - 5.5e-73 245.5 1.1 1.4e-72 244.2 0.7 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 CCF43671.1 - 2.1e-35 121.1 0.1 5.5e-35 119.7 0.0 1.8 2 0 0 2 2 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.16 CCF43671.1 - 3.9e-31 108.5 1.5 3.6e-26 92.2 0.4 2.6 2 0 0 2 2 2 2 Acyl transferase domain PS-DH PF14765.1 CCF43671.1 - 3.8e-22 78.8 0.1 7.2e-22 77.8 0.1 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Methyltransf_12 PF08242.7 CCF43671.1 - 3e-15 56.5 0.0 9.1e-15 54.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Abhydrolase_3 PF07859.8 CCF43671.1 - 1.5e-12 47.5 0.0 1.5e-10 40.9 0.0 2.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Methyltransf_23 PF13489.1 CCF43671.1 - 2.4e-11 43.6 0.0 2.4e-10 40.3 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain PP-binding PF00550.20 CCF43671.1 - 3.5e-10 40.0 1.4 6.7e-10 39.0 0.4 2.0 2 0 0 2 2 1 1 Phosphopantetheine attachment site Abhydrolase_5 PF12695.2 CCF43671.1 - 4.1e-10 39.5 0.1 4.9e-08 32.8 0.0 3.0 3 0 0 3 3 2 1 Alpha/beta hydrolase family Methyltransf_31 PF13847.1 CCF43671.1 - 1.5e-09 37.5 0.0 3.8e-09 36.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Peptidase_S9 PF00326.16 CCF43671.1 - 5.9e-09 35.4 0.0 7.4e-06 25.3 0.0 2.7 3 0 0 3 3 3 2 Prolyl oligopeptidase family Thiolase_N PF00108.18 CCF43671.1 - 1.1e-06 27.8 0.1 2.3e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_25 PF13649.1 CCF43671.1 - 2.7e-06 27.6 0.1 9.7e-06 25.8 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF43671.1 - 6.6e-06 26.5 0.0 2.1e-05 24.9 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF43671.1 - 5.5e-05 23.7 0.0 0.00019 21.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF43671.1 - 0.0066 16.4 0.1 0.024 14.6 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain ABC_trans_N PF14510.1 CCF43671.1 - 0.0079 16.2 0.1 0.025 14.6 0.0 1.8 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal ACP_syn_III PF08545.5 CCF43671.1 - 0.026 14.1 1.9 0.31 10.7 0.3 2.7 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Ubie_methyltran PF01209.13 CCF43671.1 - 0.035 13.2 0.0 0.072 12.1 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Abhydrolase_2 PF02230.11 CCF43671.1 - 0.038 13.4 0.0 1.4 8.2 0.0 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Methyltransf_28 PF02636.12 CCF43671.1 - 0.044 13.1 0.0 0.073 12.4 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF829 PF05705.9 CCF43671.1 - 0.05 13.2 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) HTH_6 PF01418.12 CCF43671.1 - 0.2 11.4 0.0 0.47 10.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family COesterase PF00135.23 CCF43671.1 - 0.38 9.3 0.0 1.7 7.2 0.0 1.8 2 0 0 2 2 2 0 Carboxylesterase family DUF2920 PF11144.3 CCF43671.1 - 1.2 8.0 0.0 2 7.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) HTH_Tnp_Tc5 PF03221.11 CCF43672.1 - 4e-05 23.3 0.2 7.1e-05 22.5 0.0 1.5 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF43672.1 - 0.00014 21.3 0.0 0.00023 20.6 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain His_Phos_2 PF00328.17 CCF43673.1 - 1.6e-19 70.4 0.0 2.8e-19 69.6 0.0 1.4 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Glyco_hydro_16 PF00722.16 CCF43674.1 - 5.4e-42 143.1 3.8 8.3e-42 142.5 2.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 DUF2201_N PF13203.1 CCF43674.1 - 1.1 8.3 3.7 1.5 7.8 2.5 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain AF-4 PF05110.8 CCF43674.1 - 1.8 6.3 17.0 2.5 5.8 11.8 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF3821 PF12863.2 CCF43675.1 - 0.007 16.0 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3821) Suf PF05843.9 CCF43675.1 - 0.0099 15.6 4.5 0.011 15.4 3.1 1.2 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Zip PF02535.17 CCF43675.1 - 0.02 13.8 6.2 0.022 13.8 4.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CPSF73-100_C PF11718.3 CCF43675.1 - 2.8 7.2 5.9 4.7 6.4 4.1 1.3 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term DUF4175 PF13779.1 CCF43675.1 - 6.9 4.2 16.1 6.1 4.4 8.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) PAT1 PF09770.4 CCF43675.1 - 8.1 4.5 22.9 9.9 4.2 15.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF1446 PF07287.6 CCF43676.1 - 2.7e-111 371.5 0.0 3.2e-111 371.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1446) F420_oxidored PF03807.12 CCF43678.1 - 0.0019 18.6 0.5 0.002 18.5 0.3 1.1 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.13 CCF43678.1 - 0.0024 17.5 1.1 0.0027 17.4 0.8 1.0 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.10 CCF43678.1 - 0.021 14.6 0.2 0.023 14.5 0.1 1.0 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.14 CCF43678.1 - 0.11 11.6 0.4 0.11 11.6 0.3 1.0 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain tRNA-synt_1 PF00133.17 CCF43680.1 - 5.4e-213 708.3 0.0 3.1e-212 705.8 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 CCF43680.1 - 1.2e-31 109.5 0.1 3.3e-31 108.0 0.1 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 CCF43680.1 - 3.3e-13 49.0 0.0 6.2e-05 21.8 0.0 4.5 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 CCF43680.1 - 1.8e-11 43.6 6.0 1.5e-08 34.1 0.0 3.2 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.4 CCF43680.1 - 0.0032 17.5 5.1 0.0032 17.5 3.6 3.8 3 0 0 3 3 3 1 Valyl tRNA synthetase tRNA binding arm PepSY PF03413.14 CCF43680.1 - 0.65 10.6 0.0 0.65 10.6 0.0 3.6 4 0 0 4 4 4 0 Peptidase propeptide and YPEB domain SHR3_chaperone PF08229.6 CCF43681.1 - 5.2e-72 240.9 0.0 5.8e-72 240.7 0.0 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 SlyX PF04102.7 CCF43682.1 - 0.0036 17.6 0.1 0.61 10.4 0.0 2.5 2 0 0 2 2 2 2 SlyX DUF1706 PF08020.6 CCF43682.1 - 0.16 11.4 0.0 0.31 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1706) UPF0020 PF01170.13 CCF43683.1 - 1.7e-13 50.5 0.0 2.7e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_26 PF13659.1 CCF43683.1 - 2e-09 37.4 0.0 4e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PC_rep PF01851.17 CCF43684.1 - 2e-20 71.8 14.2 2.1e-05 24.5 0.2 8.6 9 0 0 9 9 9 3 Proteasome/cyclosome repeat HEAT_2 PF13646.1 CCF43684.1 - 3e-09 37.0 0.9 0.00013 22.2 0.0 3.5 3 0 0 3 3 3 2 HEAT repeats Methyltransf_21 PF05050.7 CCF43684.1 - 0.024 14.5 0.0 0.049 13.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase FkbM domain DLIC PF05783.6 CCF43686.1 - 1.3e-26 93.3 0.0 4.8e-26 91.4 0.0 1.9 2 1 0 2 2 2 1 Dynein light intermediate chain (DLIC) zf-ZPR1 PF03367.8 CCF43687.1 - 9.4e-104 343.4 0.0 7.8e-51 171.4 0.0 2.4 2 0 0 2 2 2 2 ZPR1 zinc-finger domain Lipoprot_C PF08794.5 CCF43687.1 - 0.034 13.9 0.1 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 Lipoprotein GNA1870 C terminal like DUF2561 PF10812.3 CCF43688.1 - 0.0085 15.7 1.0 0.024 14.2 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2561) 7tm_1 PF00001.16 CCF43688.1 - 4.6 6.3 13.9 0.13 11.3 4.3 2.2 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) PDR_CDR PF06422.7 CCF43689.1 - 0.00016 21.2 0.1 0.00021 20.8 0.1 1.1 1 0 0 1 1 1 1 CDR ABC transporter GRAM PF02893.15 CCF43690.1 - 1.1e-17 63.2 0.0 2e-17 62.4 0.0 1.5 1 0 0 1 1 1 1 GRAM domain NOA36 PF06524.7 CCF43690.1 - 0.023 13.9 0.3 0.046 12.9 0.2 1.5 1 0 0 1 1 1 0 NOA36 protein DUF4005 PF13178.1 CCF43690.1 - 0.023 14.8 0.8 0.023 14.8 0.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4005) TFIIA PF03153.8 CCF43690.1 - 0.31 10.8 8.2 0.67 9.7 5.7 1.6 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Con-6 PF10346.4 CCF43691.1 - 7.5e-15 54.0 4.3 6.3e-12 44.7 0.4 2.1 2 0 0 2 2 2 2 Conidiation protein 6 Prosystemin PF07376.6 CCF43691.1 - 0.049 13.0 0.6 0.052 12.9 0.4 1.0 1 0 0 1 1 1 0 Prosystemin Ketoacyl-synt_C PF02801.17 CCF43694.1 - 4.8e-36 123.1 0.0 6e-36 122.9 0.0 1.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PPR_2 PF13041.1 CCF43695.1 - 0.00066 19.5 0.0 0.0091 15.9 0.0 2.6 2 0 0 2 2 2 1 PPR repeat family PPR_1 PF12854.2 CCF43695.1 - 0.0039 16.6 0.0 0.011 15.1 0.0 1.9 1 0 0 1 1 1 1 PPR repeat PPR PF01535.15 CCF43695.1 - 0.063 13.2 0.0 0.5 10.4 0.0 2.5 2 0 0 2 2 2 0 PPR repeat GDPD PF03009.12 CCF43696.1 - 2.8e-69 233.4 0.0 1.5e-68 231.0 0.0 2.2 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.2 CCF43696.1 - 1e-31 109.1 1.0 1.8e-11 44.2 0.1 4.8 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) SPX PF03105.14 CCF43696.1 - 1.4e-28 100.4 4.9 1.7e-17 64.1 1.1 3.4 1 1 1 2 2 2 2 SPX domain Ank_4 PF13637.1 CCF43696.1 - 1.6e-27 95.3 1.7 2.1e-09 37.6 0.1 5.6 5 0 0 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.25 CCF43696.1 - 3.5e-25 86.4 5.5 1.4e-05 24.6 0.0 7.3 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.1 CCF43696.1 - 5.5e-21 74.1 3.0 1.2e-05 25.3 0.0 6.1 3 1 3 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF43696.1 - 1.4e-15 55.8 0.8 0.0054 16.8 0.0 6.7 6 0 0 6 6 6 4 Ankyrin repeat GAS PF13851.1 CCF43697.1 - 8.7e-05 21.8 110.1 0.00086 18.5 9.3 7.4 3 2 4 7 7 7 5 Growth-arrest specific micro-tubule binding Reo_sigmaC PF04582.7 CCF43697.1 - 0.00011 21.5 35.8 0.087 11.9 3.7 5.6 3 2 2 5 5 5 4 Reovirus sigma C capsid protein Phage_GP20 PF06810.6 CCF43697.1 - 0.00051 19.5 6.9 0.00051 19.5 4.7 8.1 5 2 5 10 10 10 3 Phage minor structural protein GP20 Filament PF00038.16 CCF43697.1 - 0.0037 16.7 97.0 0.0097 15.4 9.7 7.5 3 2 5 8 8 8 5 Intermediate filament protein Bap31 PF05529.7 CCF43697.1 - 0.0069 15.8 2.7 0.0069 15.8 1.9 8.9 5 3 4 9 9 9 2 B-cell receptor-associated protein 31-like CENP-F_leu_zip PF10473.4 CCF43697.1 - 0.008 16.0 26.4 0.008 16.0 18.3 6.2 3 2 2 6 6 6 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.6 CCF43697.1 - 0.0081 15.9 26.0 0.0081 15.9 18.0 7.5 3 2 3 6 6 6 1 Autophagy protein 16 (ATG16) HOOK PF05622.7 CCF43697.1 - 0.0084 13.9 82.5 0.012 13.4 1.0 3.6 3 0 0 3 3 3 2 HOOK protein DUF4179 PF13786.1 CCF43697.1 - 3.2 8.0 7.6 0.28 11.4 0.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4179) Fib_alpha PF08702.5 CCF43697.1 - 8 6.5 69.1 0.35 10.9 4.8 7.2 3 2 3 7 7 7 0 Fibrinogen alpha/beta chain family TRP PF06011.7 CCF43698.1 - 7.2e-124 413.6 27.4 8.4e-124 413.4 19.0 1.0 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel gpUL132 PF11359.3 CCF43698.1 - 0.12 11.6 0.0 0.27 10.5 0.0 1.5 1 0 0 1 1 1 0 Glycoprotein UL132 ABC2_membrane PF01061.19 CCF43700.1 - 2.9e-14 52.7 8.4 2.9e-14 52.7 5.8 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 CCF43700.1 - 1.3e-06 27.7 17.7 1.5e-06 27.4 12.3 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.2 CCF43700.1 - 0.0046 15.8 10.4 0.005 15.7 7.2 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein EamA PF00892.15 CCF43700.1 - 2.3 8.2 16.0 0.13 12.2 5.3 2.4 2 1 0 2 2 2 0 EamA-like transporter family ABC2_membrane_4 PF12730.2 CCF43700.1 - 3.3 6.8 20.6 2.3 7.3 12.0 1.9 1 1 1 2 2 2 0 ABC-2 family transporter protein DUF1212 PF06738.7 CCF43700.1 - 7.6 5.9 13.5 1 8.7 6.3 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1212) FAA_hydrolase PF01557.13 CCF43702.1 - 3.8e-51 173.6 0.0 5.7e-51 173.0 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.6 CCF43702.1 - 6.8e-28 96.7 0.0 2.8e-27 94.7 0.0 1.9 2 0 0 2 2 2 1 Fumarylacetoacetase N-terminal Glyco_hydro_18 PF00704.23 CCF43703.1 - 3.9e-71 240.2 0.0 4.5e-71 240.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 HLH PF00010.21 CCF43706.1 - 8e-08 31.8 0.2 2.1e-07 30.5 0.0 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain BAF1_ABF1 PF04684.8 CCF43706.1 - 0.058 12.2 42.0 0.11 11.3 29.1 1.4 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor MIP-T3 PF10243.4 CCF43706.1 - 3.1 6.1 28.1 1.1 7.6 1.9 2.1 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 NAD_binding_10 PF13460.1 CCF43708.1 - 1.6e-08 34.7 0.1 2.1e-08 34.3 0.1 1.0 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF43708.1 - 8.2e-08 31.9 0.0 1e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF43708.1 - 0.00051 18.8 0.0 0.00068 18.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.19 CCF43708.1 - 0.0042 17.3 0.1 0.011 16.0 0.0 1.7 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.8 CCF43708.1 - 0.011 14.9 0.8 0.086 12.0 0.6 2.0 1 1 0 1 1 1 0 NmrA-like family NAD_binding_4 PF07993.7 CCF43708.1 - 0.047 12.5 0.1 2.6 6.8 0.0 2.1 2 0 0 2 2 2 0 Male sterility protein DUF3529 PF12046.3 CCF43709.1 - 0.12 11.4 0.5 3 6.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3529) Bestrophin PF01062.16 CCF43709.1 - 0.13 11.1 2.8 0.24 10.2 1.9 1.4 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel MAPEG PF01124.13 CCF43710.1 - 6e-15 55.0 0.4 7.2e-15 54.7 0.3 1.2 1 0 0 1 1 1 1 MAPEG family BTP PF05232.7 CCF43710.1 - 0.01 15.5 0.0 0.027 14.1 0.0 1.7 1 0 0 1 1 1 0 Bacterial Transmembrane Pair family CLN3 PF02487.12 CCF43712.1 - 8.6e-08 31.3 0.8 1e-07 31.1 0.6 1.0 1 0 0 1 1 1 1 CLN3 protein MFS_1 PF07690.11 CCF43712.1 - 0.009 14.7 10.8 0.011 14.4 7.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily HemY_N PF07219.8 CCF43712.1 - 0.11 12.1 0.2 0.19 11.2 0.2 1.3 1 0 0 1 1 1 0 HemY protein N-terminus 3D PF06725.6 CCF43712.1 - 0.13 12.2 0.1 0.23 11.4 0.1 1.4 1 0 0 1 1 1 0 3D domain p450 PF00067.17 CCF43714.1 - 3.7e-42 144.4 0.0 4.5e-42 144.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Cnd1 PF12717.2 CCF43714.1 - 0.086 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Med9 PF07544.8 CCF43715.1 - 0.034 13.8 0.5 0.13 12.0 0.4 2.1 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 adh_short PF00106.20 CCF43717.1 - 1e-18 67.7 0.8 2.4e-18 66.5 0.5 1.6 1 1 1 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF43717.1 - 2.6e-18 66.7 0.0 3.4e-18 66.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF43717.1 - 2.1e-07 30.7 0.1 3e-07 30.2 0.1 1.2 1 0 0 1 1 1 1 KR domain PEPCK_ATP PF01293.15 CCF43718.1 - 1.2e-11 43.8 0.0 1.3e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AMP-binding PF00501.23 CCF43719.1 - 9.4e-87 291.0 0.1 1.2e-86 290.7 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF43719.1 - 4.5e-10 40.3 0.0 1e-09 39.2 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Antitoxin-MazE PF04014.13 CCF43719.1 - 0.13 12.0 0.0 17 5.2 0.0 2.5 2 0 0 2 2 2 0 Antidote-toxin recognition MazE Abhydrolase_6 PF12697.2 CCF43720.1 - 6e-18 65.5 2.4 8.3e-18 65.0 1.6 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF43720.1 - 7.1e-10 38.8 0.0 1.1e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF43720.1 - 1e-05 25.2 0.0 6.1e-05 22.6 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 CCF43720.1 - 0.1 12.4 0.1 0.43 10.4 0.1 2.1 1 1 1 2 2 2 0 Putative lysophospholipase DUF1446 PF07287.6 CCF43721.1 - 3.6e-58 196.7 0.1 4.2e-58 196.5 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1446) MFS_1 PF07690.11 CCF43722.1 - 1.1e-20 73.7 19.4 1.3e-20 73.4 13.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF43722.1 - 8e-07 27.9 7.6 9.5e-07 27.7 5.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter FA_desaturase PF00487.19 CCF43722.1 - 3 7.2 13.7 0.18 11.2 0.4 2.2 1 1 1 2 2 2 0 Fatty acid desaturase CBM_1 PF00734.13 CCF43723.1 - 9.6e-11 41.1 11.1 9.6e-11 41.1 7.7 2.2 3 0 0 3 3 3 1 Fungal cellulose binding domain AAA_11 PF13086.1 CCF43724.1 - 8.9e-52 176.0 2.5 8.8e-31 107.2 0.2 2.3 1 1 1 2 2 2 2 AAA domain AAA_12 PF13087.1 CCF43724.1 - 5.7e-39 133.5 0.0 1.1e-38 132.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CCF43724.1 - 3.4e-14 52.3 0.1 6.6e-14 51.4 0.1 1.4 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 CCF43724.1 - 1.7e-13 50.5 0.0 5e-13 49.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 CCF43724.1 - 5.7e-07 29.5 0.0 1.1e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PIF1 PF05970.9 CCF43724.1 - 7.5e-07 28.4 0.0 1.1e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Helicase_RecD PF05127.9 CCF43724.1 - 2.1e-05 24.2 0.0 3.5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Helicase UvrD-helicase PF00580.16 CCF43724.1 - 9e-05 21.9 0.0 0.0042 16.4 0.0 2.3 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain DEAD PF00270.24 CCF43724.1 - 0.0002 20.9 0.1 0.00037 20.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.4 CCF43724.1 - 0.00061 18.8 0.0 0.0012 17.8 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) KaiC PF06745.8 CCF43724.1 - 0.0024 17.0 0.0 0.005 15.9 0.0 1.5 1 0 0 1 1 1 1 KaiC AAA_16 PF13191.1 CCF43724.1 - 0.0033 17.4 0.0 0.0048 16.8 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain SRP54 PF00448.17 CCF43724.1 - 0.0086 15.5 0.0 0.02 14.3 0.0 1.6 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SNF2_N PF00176.18 CCF43724.1 - 0.013 14.3 0.0 0.02 13.6 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain PhoH PF02562.11 CCF43724.1 - 0.042 13.0 0.0 0.14 11.4 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_22 PF13401.1 CCF43724.1 - 0.045 13.8 0.0 0.097 12.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA PF00004.24 CCF43724.1 - 0.047 13.8 0.0 0.093 12.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Helicase_C_2 PF13307.1 CCF43724.1 - 0.055 13.4 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Helicase C-terminal domain T2SE PF00437.15 CCF43724.1 - 0.086 11.7 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_25 PF13481.1 CCF43724.1 - 0.089 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 CCF43724.1 - 0.1 12.0 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_10 PF12846.2 CCF43724.1 - 0.14 11.6 0.0 0.58 9.5 0.0 1.9 1 1 1 2 2 2 0 AAA-like domain NB PF04159.8 CCF43725.1 - 0.09 12.5 0.1 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 NB glycoprotein Peptidase_S8 PF00082.17 CCF43726.1 - 5.2e-23 81.6 0.9 5.2e-23 81.6 0.7 1.9 2 0 0 2 2 2 1 Subtilase family AA_kinase PF00696.23 CCF43726.1 - 0.027 14.0 1.2 0.081 12.4 0.1 2.2 2 1 0 2 2 2 0 Amino acid kinase family ABC_membrane PF00664.18 CCF43727.1 - 1.3e-35 123.2 21.6 1.5e-35 122.9 15.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 CCF43727.1 - 1.8e-15 57.4 0.1 6.2e-14 52.4 0.1 2.2 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.1 CCF43727.1 - 3e-05 23.4 0.2 8e-05 22.0 0.2 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 CCF43727.1 - 0.0012 18.0 0.1 0.002 17.3 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_30 PF13604.1 CCF43727.1 - 0.0039 16.7 0.2 0.0075 15.8 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 CCF43727.1 - 0.0055 16.1 0.0 0.026 13.9 0.0 1.9 2 0 0 2 2 2 1 AAA-like domain AAA_17 PF13207.1 CCF43727.1 - 0.0069 17.2 0.3 0.012 16.3 0.2 1.6 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.1 CCF43727.1 - 0.0087 16.0 0.0 0.027 14.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.1 CCF43727.1 - 0.0089 16.3 2.5 0.021 15.1 1.7 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CCF43727.1 - 0.01 15.9 0.1 0.02 15.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 CCF43727.1 - 0.011 15.4 0.5 0.032 13.9 0.1 2.0 2 0 0 2 2 2 0 Part of AAA domain AAA_33 PF13671.1 CCF43727.1 - 0.023 14.5 0.0 0.046 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF3987 PF13148.1 CCF43727.1 - 0.027 13.0 0.3 0.044 12.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) SMC_N PF02463.14 CCF43727.1 - 0.031 13.4 0.0 0.05 12.8 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 CCF43727.1 - 0.045 13.7 0.1 0.13 12.2 0.0 1.8 2 0 0 2 2 1 0 AAA ATPase domain AAA_25 PF13481.1 CCF43727.1 - 0.051 12.9 0.1 0.099 12.0 0.1 1.4 1 0 0 1 1 1 0 AAA domain Glyco_hydro_3_C PF01915.17 CCF43728.1 - 0.051 13.0 1.1 0.081 12.4 0.8 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain RTA1 PF04479.8 CCF43729.1 - 5.2e-59 199.4 4.1 8.5e-59 198.7 2.8 1.3 1 0 0 1 1 1 1 RTA1 like protein GlpM PF06942.7 CCF43729.1 - 0.0071 16.5 2.5 0.0071 16.5 1.7 2.4 2 1 1 3 3 3 1 GlpM protein DUF2235 PF09994.4 CCF43730.1 - 3.1e-95 318.6 1.2 4.5e-95 318.1 0.9 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) AATF-Che1 PF13339.1 CCF43730.1 - 0.0017 18.4 0.1 0.0037 17.4 0.0 1.5 1 0 0 1 1 1 1 Apoptosis antagonizing transcription factor An_peroxidase PF03098.10 CCF43731.1 - 1.1e-51 175.8 0.0 3.7e-44 151.0 0.0 2.2 2 0 0 2 2 2 2 Animal haem peroxidase FMN_dh PF01070.13 CCF43734.1 - 1.2e-104 350.0 0.1 1.8e-104 349.4 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 CCF43734.1 - 6.7e-18 64.2 0.0 1.2e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.12 CCF43734.1 - 0.00079 18.4 0.0 0.0013 17.6 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.20 CCF43734.1 - 0.0032 16.4 0.1 0.0079 15.1 0.0 1.6 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.10 CCF43734.1 - 0.0041 16.3 0.3 0.01 15.0 0.1 1.6 1 1 1 2 2 2 1 Nitronate monooxygenase Dus PF01207.12 CCF43734.1 - 0.087 11.6 0.0 3.2 6.5 0.0 2.6 2 1 1 3 3 3 0 Dihydrouridine synthase (Dus) Peptidase_M19 PF01244.16 CCF43734.1 - 0.09 11.6 0.0 0.3 9.9 0.0 1.9 2 1 0 2 2 2 0 Membrane dipeptidase (Peptidase family M19) DUF4202 PF13875.1 CCF43735.1 - 1e-72 243.6 0.1 1.2e-72 243.5 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4202) EphA2_TM PF14575.1 CCF43736.1 - 0.04 14.3 0.0 0.077 13.4 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.15 CCF43736.1 - 0.048 13.3 1.3 0.061 12.9 0.0 1.7 2 0 0 2 2 2 0 Syndecan domain Adeno_E3_CR2 PF02439.10 CCF43736.1 - 0.049 13.1 1.6 2.3 7.8 0.1 2.4 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 SKG6 PF08693.5 CCF43736.1 - 0.053 12.8 1.9 0.2 11.0 1.3 2.0 1 0 0 1 1 1 0 Transmembrane alpha-helix domain PDGLE PF13190.1 CCF43736.1 - 0.078 12.6 0.4 0.27 10.9 0.0 2.0 2 0 0 2 2 2 0 PDGLE domain DUF1191 PF06697.7 CCF43736.1 - 0.18 10.5 0.4 0.38 9.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1191) IncA PF04156.9 CCF43736.1 - 0.26 10.8 0.0 0.26 10.8 0.0 1.5 2 0 0 2 2 2 0 IncA protein Synaptobrevin PF00957.16 CCF43737.1 - 2.3e-32 110.4 0.5 3e-32 110.0 0.3 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.1 CCF43737.1 - 2.7e-24 84.5 0.0 5e-24 83.6 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain SpoIIAA-like PF11964.3 CCF43737.1 - 0.018 15.2 0.1 0.03 14.6 0.0 1.3 1 0 0 1 1 1 0 SpoIIAA-like NAD_binding_8 PF13450.1 CCF43739.1 - 1.1e-06 28.4 0.2 1.8e-06 27.8 0.1 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF43739.1 - 9.9e-06 25.7 0.1 1.2e-05 25.4 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF43739.1 - 0.0007 19.3 0.1 0.0012 18.6 0.1 1.3 1 0 0 1 1 1 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.14 CCF43739.1 - 0.022 13.8 1.3 0.029 13.4 0.9 1.1 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.19 CCF43739.1 - 0.056 12.3 1.8 0.085 11.7 1.3 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Planc_extracel PF07595.7 CCF43739.1 - 0.16 11.6 0.8 0.35 10.6 0.5 1.5 1 0 0 1 1 1 0 Planctomycete extracellular TAF PF02969.12 CCF43741.1 - 6.3e-14 51.6 0.0 7.7e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Acyltransferase PF01553.16 CCF43742.1 - 6e-14 51.6 0.0 8.6e-14 51.1 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Raffinose_syn PF05691.7 CCF43742.1 - 0.085 10.3 0.0 0.68 7.4 0.0 1.9 2 0 0 2 2 2 0 Raffinose synthase or seed imbibition protein Sip1 Aa_trans PF01490.13 CCF43743.1 - 7.7e-82 274.9 29.5 9.3e-82 274.6 20.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Voltage_CLC PF00654.15 CCF43745.1 - 2.9e-88 296.2 26.5 2.9e-88 296.2 18.4 1.8 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.23 CCF43745.1 - 2.2e-11 43.3 0.1 4.5e-05 23.1 0.0 2.5 2 0 0 2 2 2 2 CBS domain EamA PF00892.15 CCF43746.1 - 0.0021 18.1 10.2 0.0028 17.6 6.5 1.6 1 1 1 2 2 2 1 EamA-like transporter family UPF0546 PF10639.4 CCF43746.1 - 0.0056 16.4 2.8 0.0079 15.9 2.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family UPF0546 EmrE PF13536.1 CCF43746.1 - 0.044 13.9 9.9 0.024 14.8 4.1 2.0 1 1 1 2 2 2 0 Multidrug resistance efflux transporter TFIIA_gamma_C PF02751.9 CCF43747.1 - 3.7e-26 90.6 0.7 5e-26 90.2 0.5 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.11 CCF43747.1 - 7.2e-24 83.1 0.2 1e-23 82.6 0.2 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain ATP-synt_C PF00137.16 CCF43748.1 - 1.5e-25 88.8 32.0 4.1e-16 58.6 4.9 3.0 3 1 0 3 3 3 2 ATP synthase subunit C Oxidored_q2 PF00420.19 CCF43748.1 - 3.5 7.2 8.7 3.2 7.3 3.6 2.6 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L MoCF_biosynth PF00994.19 CCF43749.1 - 7.4e-54 181.0 0.8 8.6e-30 103.0 0.0 2.4 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.12 CCF43749.1 - 1.1e-34 119.0 2.2 2e-34 118.2 1.5 1.4 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.10 CCF43749.1 - 4.7e-16 58.4 0.0 1.2e-15 57.1 0.0 1.8 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) Phage_Coat_B PF05356.6 CCF43749.1 - 0.057 13.1 0.1 0.19 11.4 0.1 1.9 1 0 0 1 1 1 0 Phage Coat protein B GST_N_3 PF13417.1 CCF43751.1 - 3.9e-11 43.0 0.2 8.5e-11 41.9 0.2 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 CCF43751.1 - 0.00032 21.1 0.0 0.00056 20.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 CCF43751.1 - 0.00044 20.0 0.0 0.00078 19.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 CCF43751.1 - 0.0042 17.0 0.0 0.012 15.6 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 CCF43751.1 - 0.018 14.9 0.0 0.03 14.3 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Aft1_HRA PF11786.3 CCF43752.1 - 2.2e-30 104.7 9.7 2.2e-30 104.7 6.7 2.3 2 0 0 2 2 2 1 Aft1 HRA domain Aft1_HRR PF11787.3 CCF43752.1 - 1.8e-21 76.9 10.1 1.8e-21 76.9 7.0 3.8 4 1 1 5 5 5 1 Aft1 HRR domain Aft1_OSA PF11785.3 CCF43752.1 - 1.8e-18 66.7 5.2 1.8e-18 66.7 3.6 6.0 6 0 0 6 6 6 1 Aft1 osmotic stress response (OSM) domain bZIP_1 PF00170.16 CCF43752.1 - 2.3e-13 49.8 6.1 3.8e-13 49.1 4.2 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 CCF43752.1 - 7.4e-07 28.9 6.1 1.5e-06 27.9 4.2 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 CCF43752.1 - 0.0026 17.9 3.1 0.0026 17.9 2.1 2.6 3 0 0 3 3 3 1 bZIP Maf transcription factor Macoilin PF09726.4 CCF43752.1 - 4.6 5.3 15.5 6.7 4.8 10.7 1.2 1 0 0 1 1 1 0 Transmembrane protein MIS13 PF08202.6 CCF43753.1 - 1.2e-59 201.8 4.2 2e-59 201.1 2.9 1.3 1 0 0 1 1 1 1 Mis12-Mtw1 protein family DivIC PF04977.10 CCF43753.1 - 9.3 5.8 8.1 8.6 5.9 2.0 2.3 2 0 0 2 2 2 0 Septum formation initiator Sdh5 PF03937.11 CCF43754.1 - 4e-23 80.8 0.5 8.2e-23 79.8 0.2 1.7 2 0 0 2 2 2 1 Flavinator of succinate dehydrogenase EMP24_GP25L PF01105.19 CCF43755.1 - 6.1e-42 143.4 0.0 6.8e-42 143.2 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD EzrA PF06160.7 CCF43755.1 - 0.038 12.1 0.2 0.048 11.8 0.1 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA zf-U1 PF06220.7 CCF43756.1 - 5.3e-22 77.0 3.4 7.9e-22 76.5 2.3 1.3 1 0 0 1 1 1 1 U1 zinc finger zf-C2H2_jaz PF12171.3 CCF43756.1 - 0.021 14.9 3.6 0.045 13.8 2.5 1.6 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Bactofilin PF04519.8 CCF43757.1 - 5.9e-06 26.2 1.7 0.00061 19.7 0.7 2.4 1 1 1 2 2 2 2 Polymer-forming cytoskeletal MinC_C PF03775.11 CCF43757.1 - 0.061 12.9 3.0 8.2 6.1 0.0 2.4 1 1 0 2 2 2 0 Septum formation inhibitor MinC, C-terminal domain DUF342 PF03961.8 CCF43757.1 - 0.066 11.6 2.9 0.19 10.1 2.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF342) ING PF12998.2 CCF43758.1 - 0.0012 19.0 0.0 0.0027 17.9 0.0 1.6 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding P_proprotein PF01483.15 CCF43759.1 - 0.014 15.1 0.2 0.019 14.7 0.2 1.2 1 0 0 1 1 1 0 Proprotein convertase P-domain zf-C2H2 PF00096.21 CCF43760.1 - 4.7e-06 26.6 4.5 1.3e-05 25.1 3.1 1.8 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-met PF12874.2 CCF43760.1 - 6.4e-06 26.1 1.5 1.3e-05 25.1 1.0 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 CCF43760.1 - 3.2e-05 23.9 2.1 8.1e-05 22.6 1.4 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 CCF43760.1 - 5.9e-05 23.1 2.3 0.00014 21.9 1.6 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CCF43760.1 - 6.5e-05 23.0 7.8 0.024 14.9 0.9 2.5 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_6 PF13912.1 CCF43760.1 - 0.0012 18.7 1.5 0.0027 17.5 1.1 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_2 PF12756.2 CCF43760.1 - 0.0032 17.5 0.1 0.0058 16.7 0.1 1.4 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-BED PF02892.10 CCF43760.1 - 0.17 11.6 1.7 0.28 10.9 1.2 1.3 1 0 0 1 1 1 0 BED zinc finger RAP1 PF07218.6 CCF43760.1 - 0.99 7.4 2.9 1.3 6.9 2.0 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Fer4 PF00037.22 CCF43762.1 - 1.5e-13 49.7 16.5 5.4e-08 32.1 2.5 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.2 CCF43762.1 - 6.9e-12 45.5 10.6 1.2e-11 44.8 7.3 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.1 CCF43762.1 - 2.5e-10 40.4 7.2 5.1e-10 39.4 5.0 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 CCF43762.1 - 2.1e-09 37.0 21.9 7.1e-08 32.1 8.4 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.1 CCF43762.1 - 2.7e-09 37.6 8.7 0.00021 21.9 0.2 2.5 3 0 0 3 3 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.1 CCF43762.1 - 9.3e-09 35.0 32.3 1.1e-05 25.1 8.7 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_8 PF13183.1 CCF43762.1 - 1.1e-07 31.7 20.3 2.4e-05 24.2 8.1 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_2 PF12797.2 CCF43762.1 - 1.3e-07 31.1 14.7 0.00044 20.0 1.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.2 CCF43762.1 - 2.4e-07 30.3 17.1 0.0012 18.5 3.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.1 CCF43762.1 - 4.5e-06 26.9 9.3 0.00097 19.4 7.7 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_4 PF12800.2 CCF43762.1 - 5.3e-06 26.3 12.7 0.00058 19.9 2.1 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_18 PF13746.1 CCF43762.1 - 3e-05 24.3 9.2 0.012 15.9 0.5 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.1 CCF43762.1 - 0.01 16.1 15.4 0.3 11.4 3.2 2.7 2 1 1 3 3 3 0 4Fe-4S single cluster domain Fer4_15 PF13459.1 CCF43762.1 - 0.013 16.0 12.9 0.22 12.1 1.1 2.8 2 1 0 2 2 2 0 4Fe-4S single cluster domain Fer4_3 PF12798.2 CCF43762.1 - 0.073 13.6 16.9 0.16 12.6 2.4 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain c-SKI_SMAD_bind PF08782.5 CCF43762.1 - 0.11 12.6 4.9 0.27 11.3 0.1 2.3 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Glyco_transf_52 PF07922.6 CCF43764.1 - 0.0069 15.4 0.0 0.0078 15.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 52 Sugar_tr PF00083.19 CCF43765.1 - 1.8e-30 105.9 19.3 2e-30 105.8 13.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Ferritin_2 PF13668.1 CCF43768.1 - 2.3e-17 63.2 0.0 3.5e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 Ferritin-like domain MFS_1 PF07690.11 CCF43769.1 - 1.7e-22 79.6 15.5 2.1e-22 79.3 10.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF43769.1 - 8.3e-12 44.4 6.0 1.1e-11 43.9 4.1 1.2 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 CCF43769.1 - 2.2e-07 29.4 3.4 2.8e-07 29.1 2.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Alpha_E2_glycop PF00943.14 CCF43769.1 - 0.0014 17.3 1.1 0.002 16.8 0.8 1.1 1 0 0 1 1 1 1 Alphavirus E2 glycoprotein MFS_2 PF13347.1 CCF43769.1 - 0.041 12.2 9.1 0.11 10.9 6.3 1.7 1 1 0 1 1 1 0 MFS/sugar transport protein BT1 PF03092.11 CCF43769.1 - 0.13 10.8 3.1 2.3 6.8 1.8 2.1 2 0 0 2 2 2 0 BT1 family zf-C3HC4_2 PF13923.1 CCF43770.1 - 1.8e-08 34.2 6.6 3.1e-08 33.4 4.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF43770.1 - 2e-08 33.7 4.9 3.4e-08 33.0 3.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF43770.1 - 8e-08 31.9 4.6 1.3e-07 31.2 3.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 CCF43770.1 - 2.1e-07 30.5 3.5 3.6e-07 29.7 2.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CCF43770.1 - 2.3e-06 27.3 3.4 5.3e-06 26.2 2.4 1.6 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 CCF43770.1 - 2.9e-06 26.8 3.8 5e-06 26.1 2.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 CCF43770.1 - 0.0018 17.9 3.8 0.0037 16.9 2.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-MIZ PF02891.15 CCF43770.1 - 0.11 12.0 4.8 0.32 10.5 3.2 1.9 1 1 1 2 2 2 0 MIZ/SP-RING zinc finger zf-rbx1 PF12678.2 CCF43770.1 - 0.25 11.4 1.6 0.7 10.0 1.1 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger TerY-C PF15616.1 CCF43770.1 - 0.39 10.6 3.2 1.5 8.7 2.2 1.9 1 1 0 1 1 1 0 TerY-C metal binding domain DUF3433 PF11915.3 CCF43771.1 - 6.9e-15 54.9 16.1 9.9e-10 38.4 0.0 4.3 3 1 1 4 4 4 3 Protein of unknown function (DUF3433) Pectate_lyase PF03211.8 CCF43774.1 - 8.2e-61 205.1 3.2 9.2e-61 204.9 2.2 1.0 1 0 0 1 1 1 1 Pectate lyase WD40 PF00400.27 CCF43775.1 - 4.6e-27 92.8 8.9 2e-07 30.6 0.1 6.3 7 0 0 7 7 7 4 WD domain, G-beta repeat Nup160 PF11715.3 CCF43775.1 - 0.0015 16.7 0.5 0.036 12.1 0.0 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Transposase_23 PF03017.9 CCF43775.1 - 0.012 15.1 0.1 0.03 13.8 0.1 1.7 1 0 0 1 1 1 0 TNP1/EN/SPM transposase Tic20 PF09685.5 CCF43776.1 - 0.0011 18.9 2.8 0.0015 18.4 1.9 1.2 1 0 0 1 1 1 1 Tic20-like protein TRF PF08558.5 CCF43778.1 - 1e-23 83.9 0.8 1.7e-23 83.1 0.5 1.3 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.26 CCF43778.1 - 3.6e-06 26.9 0.1 8.1e-06 25.7 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CCF43778.1 - 0.0054 16.8 0.0 0.013 15.5 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Tic20 PF09685.5 CCF43780.1 - 2.5 8.1 9.2 4 7.4 6.4 1.3 1 0 0 1 1 1 0 Tic20-like protein TRI5 PF06330.6 CCF43781.1 - 9.5e-05 21.2 0.0 0.00012 20.8 0.0 1.2 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) RRM_1 PF00076.17 CCF43782.1 - 7.5e-60 198.4 0.0 3.3e-21 74.7 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF43782.1 - 5.5e-44 148.0 0.0 1.1e-14 54.1 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF43782.1 - 2.8e-30 103.9 0.0 9e-11 41.4 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CCF43782.1 - 6.2e-08 32.2 0.0 0.0084 15.8 0.0 3.5 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Cas_Cas2CT1978 PF09707.5 CCF43782.1 - 0.00021 21.1 0.0 0.96 9.4 0.0 2.4 2 0 0 2 2 2 2 CRISPR-associated protein (Cas_Cas2CT1978) RRM_3 PF08777.6 CCF43782.1 - 0.046 13.5 0.0 0.93 9.3 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif ALG3 PF05208.8 CCF43783.1 - 4.9e-64 216.8 5.6 5.5e-64 216.6 3.9 1.0 1 0 0 1 1 1 1 ALG3 protein eIF-1a PF01176.14 CCF43784.1 - 4.3e-14 51.6 0.0 5.9e-14 51.2 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 GATase_4 PF13230.1 CCF43785.1 - 8.5e-19 67.2 0.0 1.1e-16 60.3 0.0 2.1 1 1 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.1 CCF43785.1 - 3.1e-09 36.8 0.0 5.2e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_2 PF00310.16 CCF43785.1 - 5.6e-07 28.5 0.0 6.7e-05 21.7 0.0 2.2 2 0 0 2 2 2 2 Glutamine amidotransferases class-II 2-Hacid_dh PF00389.25 CCF43787.1 - 6.5e-30 103.3 0.0 7.7e-30 103.0 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 2-Hacid_dh_C PF02826.14 CCF43787.1 - 8.1e-06 25.1 0.1 1.7e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF1399 PF07173.7 CCF43788.1 - 8.5e-23 81.1 0.9 6.6e-16 58.8 0.1 2.7 2 1 0 2 2 2 2 Protein of unknown function (DUF1399) OstA_C PF04453.9 CCF43788.1 - 0.13 11.3 0.1 0.21 10.6 0.0 1.3 1 0 0 1 1 1 0 Organic solvent tolerance protein MoCF_biosynth PF00994.19 CCF43789.1 - 8.3e-36 122.5 0.0 1.4e-35 121.8 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain Cofilin_ADF PF00241.15 CCF43790.1 - 1.1e-08 35.0 0.0 1.3e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Treacle PF03546.9 CCF43791.1 - 0.33 9.6 2.7 0.36 9.5 1.9 1.0 1 0 0 1 1 1 0 Treacher Collins syndrome protein Treacle CPSase_L_D2 PF02786.12 CCF43792.1 - 1e-51 175.2 0.0 1.9e-51 174.3 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 CCF43792.1 - 7.9e-25 87.0 0.1 1.5e-24 86.1 0.1 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 CCF43792.1 - 4.5e-22 78.0 0.0 2.5e-20 72.4 0.0 2.8 3 0 0 3 3 3 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.17 CCF43792.1 - 2.9e-10 39.6 0.1 6.9e-10 38.4 0.0 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_4 PF13535.1 CCF43792.1 - 3.1e-09 36.8 0.0 7.6e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 CCF43792.1 - 1.7e-08 33.6 0.0 0.0026 16.5 0.0 3.0 3 0 0 3 3 3 2 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl_2 PF13533.1 CCF43792.1 - 0.0022 17.6 0.0 0.0046 16.5 0.0 1.5 1 0 0 1 1 1 1 Biotin-lipoyl like Dala_Dala_lig_C PF07478.8 CCF43792.1 - 0.0034 16.8 0.0 0.0062 15.9 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.9 CCF43792.1 - 0.0059 16.4 0.0 0.11 12.3 0.0 3.0 4 1 0 4 4 4 1 ATP-grasp domain ATP-grasp PF02222.17 CCF43792.1 - 0.022 14.1 0.0 0.045 13.1 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain HlyD_2 PF12700.2 CCF43792.1 - 0.086 11.9 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 HlyD family secretion protein Voltage_CLC PF00654.15 CCF43793.1 - 8.9e-48 163.1 6.4 1.1e-47 162.8 4.5 1.1 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.23 CCF43793.1 - 0.0045 16.7 0.1 0.012 15.3 0.1 1.8 2 0 0 2 2 2 1 CBS domain DUF2062 PF09835.4 CCF43793.1 - 0.034 13.7 0.3 0.034 13.7 0.2 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2062) NDUF_B7 PF05676.8 CCF43794.1 - 4.7e-33 112.4 3.2 5.5e-33 112.2 2.2 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.5 CCF43794.1 - 0.00047 19.8 2.2 0.00065 19.4 1.5 1.3 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like Antifungal_prot PF11402.3 CCF43794.1 - 1.2 9.4 4.8 1.9 8.7 2.2 1.9 1 1 1 2 2 2 0 Antifungal protein Peptidase_C39_2 PF13529.1 CCF43797.1 - 0.0035 17.7 0.1 0.004 17.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase_C39 like family TauD PF02668.11 CCF43798.1 - 5.6e-14 52.4 0.2 6.1e-14 52.3 0.1 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family P16-Arc PF04699.9 CCF43798.1 - 0.084 12.8 0.0 0.092 12.7 0.0 1.1 1 0 0 1 1 1 0 ARP2/3 complex 16 kDa subunit (p16-Arc) adh_short PF00106.20 CCF43799.1 - 1.4e-13 51.1 0.1 1.6e-13 50.9 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF43799.1 - 1.9e-08 34.1 0.0 2.3e-08 33.9 0.0 1.0 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF43799.1 - 1.3e-05 25.1 0.0 1.6e-05 24.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 CCF43799.1 - 0.0014 18.6 0.1 0.0017 18.3 0.1 1.1 1 0 0 1 1 1 1 NADH(P)-binding DFP PF04127.10 CCF43799.1 - 0.0056 16.3 0.1 0.0073 15.9 0.1 1.1 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein Epimerase PF01370.16 CCF43799.1 - 0.0062 15.9 0.0 0.0074 15.7 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 CCF43799.1 - 0.027 14.2 0.5 0.074 12.8 0.0 1.9 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ADH_zinc_N PF00107.21 CCF43801.1 - 2.1e-14 53.1 0.0 3e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF43801.1 - 0.00026 21.8 0.0 0.00039 21.3 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Clathrin_propel PF01394.15 CCF43802.1 - 5.9e-36 120.2 1.6 1.7e-06 27.9 0.0 7.4 7 0 0 7 7 7 7 Clathrin propeller repeat Clathrin_H_link PF13838.1 CCF43802.1 - 5.2e-31 106.3 0.7 1.1e-30 105.2 0.5 1.6 1 0 0 1 1 1 1 Clathrin-H-link Clathrin PF00637.15 CCF43802.1 - 3.8e-13 49.2 0.0 3.5e-12 46.1 0.0 2.4 1 1 2 3 3 3 1 Region in Clathrin and VPS Clathrin-link PF09268.5 CCF43802.1 - 0.064 12.3 1.6 0.075 12.0 0.1 2.0 2 0 0 2 2 2 0 Clathrin, heavy-chain linker DUF4131 PF13567.1 CCF43804.1 - 0.26 10.6 5.2 0.39 10.1 3.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) RhoGAP PF00620.22 CCF43805.1 - 3.9e-39 133.6 0.0 6.7e-39 132.9 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain Glyco_transf_22 PF03901.12 CCF43806.1 - 3.7e-79 266.7 22.2 4.3e-79 266.4 15.4 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family LigD_N PF13298.1 CCF43806.1 - 0.037 14.1 0.0 0.066 13.3 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase Ligase (LigD) Aminotran_3 PF00202.16 CCF43807.1 - 4.2e-108 361.1 0.0 5.1e-108 360.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 CCF43807.1 - 8.2e-06 25.1 0.0 1.4e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 CCF43807.1 - 0.11 11.3 0.0 0.22 10.4 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II Nol1_Nop2_Fmu PF01189.12 CCF43808.1 - 4.1e-19 69.0 0.0 1.7e-13 50.5 0.0 2.3 2 0 0 2 2 2 2 NOL1/NOP2/sun family Band_7 PF01145.20 CCF43809.1 - 5e-14 52.6 0.1 5e-14 52.6 0.0 3.3 2 2 0 2 2 2 1 SPFH domain / Band 7 family SDH_alpha PF03313.10 CCF43811.1 - 7.6e-05 21.8 0.0 8e-05 21.8 0.0 1.0 1 0 0 1 1 1 1 Serine dehydratase alpha chain PAN_4 PF14295.1 CCF43812.1 - 0.00069 19.2 7.3 0.038 13.7 0.3 3.0 2 1 0 2 2 2 2 PAN domain PTPLA PF04387.9 CCF43813.1 - 1.5e-53 180.5 13.6 2.3e-53 179.9 9.5 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA CHAD PF05235.9 CCF43814.1 - 0.054 13.0 0.0 0.055 13.0 0.0 1.1 1 0 0 1 1 1 0 CHAD domain MFS_1 PF07690.11 CCF43820.1 - 2.1e-36 125.3 70.3 5.1e-36 124.1 47.2 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF43820.1 - 1.2e-13 50.1 26.4 1.6e-13 49.7 17.0 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 CCF43820.1 - 8.5e-13 47.6 17.8 8.5e-13 47.6 12.3 2.6 2 0 0 2 2 2 2 Sugar (and other) transporter Zn_clus PF00172.13 CCF43821.1 - 7.8e-07 28.9 10.0 1.6e-06 27.9 6.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF43821.1 - 2.4e-06 26.4 0.0 5.1e-06 25.3 0.0 1.5 1 1 1 2 2 2 1 Fungal specific transcription factor domain RRN7 PF11781.3 CCF43821.1 - 0.044 13.2 2.3 0.11 12.0 1.6 1.7 1 0 0 1 1 1 0 RNA polymerase I-specific transcription initiation factor Rrn7 DUF4449 PF14613.1 CCF43821.1 - 0.068 13.0 0.1 0.26 11.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4449) LSM PF01423.17 CCF43823.1 - 1.2e-18 66.3 0.7 1.5e-18 66.0 0.5 1.1 1 0 0 1 1 1 1 LSM domain Dppa2_A PF14049.1 CCF43823.1 - 0.08 12.8 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Dppa2/4 conserved region in higher vertebrates NTR2 PF15458.1 CCF43824.1 - 3.9e-05 23.0 2.8 3.9e-05 23.0 1.9 1.9 3 0 0 3 3 3 1 Nineteen complex-related protein 2 SOCS PF12610.3 CCF43827.1 - 2.2 8.6 8.7 0.52 10.6 2.1 2.3 2 0 0 2 2 2 0 Suppressor of cytokine signalling Methyltransf_23 PF13489.1 CCF43828.1 - 3.4e-18 65.8 0.0 5.8e-18 65.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF43828.1 - 1.9e-11 44.4 0.0 7.7e-11 42.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF43828.1 - 4.5e-10 39.3 0.0 1.5e-09 37.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF43828.1 - 2e-06 28.2 0.0 8.8e-06 26.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF43828.1 - 1.6e-05 25.3 0.0 3.1e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF43828.1 - 3.4e-05 24.1 0.0 0.00041 20.6 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 CCF43828.1 - 9.9e-05 22.4 0.1 0.00022 21.2 0.0 1.8 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_26 PF13659.1 CCF43828.1 - 0.00012 22.0 0.0 0.00026 20.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF43828.1 - 0.0018 17.3 0.0 0.0047 15.9 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase PCMT PF01135.14 CCF43828.1 - 0.005 16.3 0.0 0.02 14.4 0.0 1.9 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.9 CCF43828.1 - 0.0072 15.7 0.0 0.032 13.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.13 CCF43828.1 - 0.049 12.7 0.0 0.22 10.5 0.0 2.1 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.13 CCF43828.1 - 0.05 12.7 0.0 0.091 11.9 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase CMAS PF02353.15 CCF43828.1 - 0.15 11.0 0.0 0.3 10.1 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Glyco_hydro_cc PF11790.3 CCF43831.1 - 8.6e-21 74.4 0.2 1.2e-20 73.9 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core DUF1308 PF07000.6 CCF43832.1 - 1.9e-43 148.4 0.0 2.4e-43 148.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1308) DUF3745 PF12560.3 CCF43832.1 - 0.18 11.4 0.1 0.35 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3745) Peptidase_M43 PF05572.8 CCF43833.1 - 6.6e-19 68.0 0.3 8.2e-19 67.7 0.2 1.2 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_2 PF13574.1 CCF43833.1 - 2.7e-08 34.0 0.1 4e-08 33.5 0.1 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 CCF43833.1 - 4.1e-06 26.8 0.2 5.1e-06 26.5 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.1 CCF43833.1 - 6e-06 25.9 0.1 7.1e-06 25.6 0.1 1.1 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.1 CCF43833.1 - 1.5e-05 25.4 0.1 2.9e-05 24.5 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.4 CCF43833.1 - 0.0014 17.6 0.0 0.0016 17.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase M66 Peptidase_M10 PF00413.19 CCF43833.1 - 0.0069 16.1 0.0 0.011 15.4 0.0 1.5 1 1 0 1 1 1 1 Matrixin Peptidase_M57 PF12388.3 CCF43833.1 - 0.012 14.9 0.9 0.021 14.1 0.6 1.4 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Peptidase_M54 PF07998.6 CCF43833.1 - 0.014 15.2 0.1 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M7 PF02031.11 CCF43833.1 - 0.043 13.5 0.4 0.085 12.5 0.3 1.6 1 1 0 1 1 1 0 Streptomyces extracellular neutral proteinase (M7) family Peptidase_M28 PF04389.12 CCF43834.1 - 2.1e-35 122.0 0.2 8.6e-35 120.0 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.23 CCF43834.1 - 7.6e-08 32.0 0.0 1.4e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Glucosaminidase PF01832.15 CCF43834.1 - 0.056 13.5 0.0 2.2 8.4 0.0 2.4 2 0 0 2 2 2 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase PepSY_2 PF13670.1 CCF43835.1 - 0.013 15.3 3.9 1.6 8.7 0.3 2.2 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Gamma-thionin PF00304.15 CCF43835.1 - 0.14 12.1 4.1 0.22 11.5 2.8 1.3 1 0 0 1 1 1 0 Gamma-thionin family CN_hydrolase PF00795.17 CCF43836.1 - 2.1e-24 85.9 0.0 2.8e-24 85.5 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Fungal_trans PF04082.13 CCF43837.1 - 1.5e-13 50.2 0.0 3.2e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_transf_17 PF04724.8 CCF43838.1 - 3e-45 154.7 0.2 3.9e-45 154.4 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 17 HTH_Tnp_Tc3_2 PF01498.13 CCF43839.1 - 0.00016 21.6 0.1 0.00067 19.6 0.0 1.9 1 1 1 2 2 2 1 Transposase HTH_32 PF13565.1 CCF43839.1 - 0.00016 22.3 6.3 0.00042 21.0 0.6 2.7 1 1 2 3 3 3 1 Homeodomain-like domain HTH_29 PF13551.1 CCF43839.1 - 0.00071 19.7 0.6 0.0014 18.7 0.3 1.6 1 1 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_1 PF01527.15 CCF43839.1 - 0.0078 16.1 0.2 0.07 13.1 0.1 2.1 1 1 1 2 2 2 1 Transposase HTH_38 PF13936.1 CCF43839.1 - 0.014 14.9 0.2 0.04 13.4 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.1 CCF43839.1 - 0.028 14.0 0.0 0.069 12.8 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_7 PF02796.10 CCF43839.1 - 0.029 14.2 0.6 7.6 6.4 0.0 2.6 2 1 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_28 PF13518.1 CCF43839.1 - 0.032 14.2 0.2 0.032 14.2 0.1 2.6 3 0 0 3 3 3 0 Helix-turn-helix domain FYDLN_acid PF09538.5 CCF43840.1 - 0.34 11.4 10.9 0.74 10.4 7.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DnaJ PF00226.26 CCF43841.1 - 1.5e-22 79.0 0.3 2.2e-22 78.5 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain DUF2416 PF10315.4 CCF43842.1 - 0.0048 17.1 0.4 0.19 12.0 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2416) Prp18 PF02840.10 CCF43843.1 - 5.5e-19 68.4 0.0 6.1e-19 68.2 0.0 1.0 1 0 0 1 1 1 1 Prp18 domain RPN7 PF10602.4 CCF43844.1 - 1e-22 80.3 0.0 2.5e-22 79.1 0.0 1.6 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.22 CCF43844.1 - 2.1e-13 50.4 0.0 3.9e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 PCI domain PMT PF02366.13 CCF43845.1 - 3.4e-81 272.2 13.9 4e-81 271.9 9.6 1.0 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_2 PF13231.1 CCF43845.1 - 8.1e-06 25.8 11.7 8.1e-06 25.8 8.1 2.2 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF2976 PF11190.3 CCF43845.1 - 0.0047 16.4 3.3 0.038 13.5 1.3 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2976) DUF4345 PF14248.1 CCF43845.1 - 0.62 9.5 10.4 0.48 9.8 0.1 2.8 2 1 0 3 3 3 0 Domain of unknown function (DUF4345) Bax1-I PF01027.15 CCF43845.1 - 4.3 6.8 14.8 10 5.6 2.0 2.9 1 1 1 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 UQ_con PF00179.21 CCF43847.1 - 4.9e-49 165.3 0.1 5.5e-49 165.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CCF43847.1 - 6.4e-05 22.7 0.0 7.2e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 CCF43847.1 - 0.011 15.6 1.8 0.022 14.6 1.3 1.8 1 1 0 1 1 1 0 RWD domain FAD_binding_6 PF00970.19 CCF43848.1 - 1.9e-27 95.2 0.0 3.2e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 CCF43848.1 - 2.6e-26 92.3 0.0 3.8e-26 91.7 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 CCF43848.1 - 3.8e-05 23.6 0.0 0.0057 16.5 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.6 CCF43848.1 - 0.028 14.3 0.0 0.049 13.6 0.0 1.4 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain G-patch_2 PF12656.2 CCF43849.1 - 2.9e-17 62.2 0.3 2.9e-17 62.2 0.2 2.7 3 0 0 3 3 3 1 DExH-box splicing factor binding site DNase-RNase PF02577.9 CCF43849.1 - 0.069 12.3 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Bifunctional nuclease Sugar_tr PF00083.19 CCF43850.1 - 4.9e-71 239.6 18.0 5.8e-71 239.3 12.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF43850.1 - 1.5e-14 53.5 24.7 1.5e-14 53.5 17.1 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF43850.1 - 2.1e-05 23.1 4.0 2.1e-05 23.1 2.8 3.0 2 1 1 3 3 3 2 MFS/sugar transport protein HpcH_HpaI PF03328.9 CCF43852.1 - 1.6e-31 108.9 0.0 1.9e-31 108.6 0.0 1.0 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PEP_mutase PF13714.1 CCF43852.1 - 0.12 11.5 0.1 13 4.9 0.0 2.8 2 1 0 3 3 3 0 Phosphoenolpyruvate phosphomutase DUF836 PF05768.9 CCF43853.1 - 1.2e-14 54.2 0.0 1.5e-14 54.0 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.19 CCF43853.1 - 0.00084 19.2 0.0 0.0014 18.5 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin Glyco_transf_20 PF00982.16 CCF43854.1 - 6.3e-146 486.5 0.0 9e-146 486.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 CCF43854.1 - 5.4e-41 140.0 0.0 1.2e-40 138.8 0.0 1.6 2 0 0 2 2 2 1 Trehalose-phosphatase Glyco_trans_1_4 PF13692.1 CCF43854.1 - 0.084 13.0 0.0 1.2 9.3 0.0 2.6 2 1 0 2 2 2 0 Glycosyl transferases group 1 Pyridoxal_deC PF00282.14 CCF43855.1 - 3.3e-79 266.0 0.0 4.1e-79 265.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.16 CCF43855.1 - 2.2e-05 23.7 0.0 3.2e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 CCF43855.1 - 0.005 15.6 0.0 0.0072 15.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V GMC_oxred_N PF00732.14 CCF43856.1 - 3.4e-45 154.4 0.5 4.5e-45 154.0 0.4 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF43856.1 - 1.1e-25 90.5 0.8 1.6e-24 86.8 0.0 2.6 2 1 0 2 2 2 1 GMC oxidoreductase DAO PF01266.19 CCF43856.1 - 1.4e-09 37.3 0.7 5.2e-05 22.3 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CCF43856.1 - 3.2e-08 32.8 2.3 6.2e-08 31.8 1.6 1.4 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 CCF43856.1 - 1.8e-07 31.2 0.2 1.8e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF43856.1 - 1.2e-06 27.8 0.4 3e-05 23.2 0.2 2.3 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.1 CCF43856.1 - 2.6e-06 27.3 0.2 1.3e-05 25.0 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 CCF43856.1 - 3.2e-06 26.4 0.1 5e-06 25.7 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 CCF43856.1 - 0.001 17.6 0.9 0.0051 15.3 0.1 2.0 2 0 0 2 2 2 1 HI0933-like protein GDI PF00996.13 CCF43856.1 - 0.0056 15.0 0.1 0.0084 14.4 0.0 1.1 1 0 0 1 1 1 1 GDP dissociation inhibitor 3HCDH_N PF02737.13 CCF43856.1 - 0.011 15.3 0.1 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.17 CCF43856.1 - 0.017 14.0 0.2 0.063 12.1 0.0 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 CCF43856.1 - 0.018 15.0 0.9 5.8 6.9 0.1 2.9 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 CCF43856.1 - 0.021 13.8 1.9 0.037 13.1 1.3 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.16 CCF43856.1 - 0.058 12.9 0.2 0.1 12.1 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.9 CCF43856.1 - 0.071 12.4 1.4 0.11 11.8 1.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.22 CCF43856.1 - 0.12 12.7 0.9 0.25 11.7 0.7 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MoaC PF01967.16 CCF43857.1 - 2.5e-12 46.6 1.0 4e-12 45.9 0.2 1.6 2 0 0 2 2 2 1 MoaC family RNA_pol_Rpb2_7 PF04560.15 CCF43857.1 - 0.096 12.9 0.0 0.16 12.2 0.0 1.4 1 1 0 1 1 1 0 RNA polymerase Rpb2, domain 7 DUF2296 PF10058.4 CCF43858.1 - 3e-20 71.6 0.3 9.4e-20 70.1 0.1 1.9 2 0 0 2 2 2 1 Predicted integral membrane metal-binding protein (DUF2296) DUF4231 PF14015.1 CCF43858.1 - 0.12 12.3 0.4 0.2 11.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) DUF605 PF04652.11 CCF43858.1 - 0.43 9.9 7.2 0.62 9.3 5.0 1.2 1 0 0 1 1 1 0 Vta1 like SET PF00856.23 CCF43859.1 - 9.8e-10 38.9 0.0 9e-09 35.8 0.0 2.2 1 1 0 1 1 1 1 SET domain EHN PF06441.7 CCF43862.1 - 6.5e-35 119.4 0.1 8.7e-35 119.0 0.1 1.2 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_6 PF12697.2 CCF43862.1 - 1.6e-08 34.7 0.2 2.9e-08 33.8 0.1 1.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF43862.1 - 8.4e-08 32.0 0.1 1.3e-07 31.3 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF43862.1 - 0.0078 15.9 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF1736 PF08409.6 CCF43863.1 - 1.5 8.4 5.5 7.8 6.1 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1736) adh_short PF00106.20 CCF43864.1 - 5.1e-14 52.5 2.9 1.2e-13 51.3 2.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.16 CCF43864.1 - 2.3e-05 23.9 0.1 3.2e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 CCF43864.1 - 0.00026 20.6 0.6 0.00076 19.2 0.1 2.0 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_10 PF13460.1 CCF43864.1 - 0.0043 17.0 0.3 0.0076 16.2 0.2 1.5 1 1 0 1 1 1 1 NADH(P)-binding KR PF08659.5 CCF43864.1 - 0.0053 16.4 3.3 0.11 12.1 2.3 2.7 1 1 0 1 1 1 1 KR domain Polysacc_lyase PF14099.1 CCF43865.1 - 0.028 14.0 0.0 0.04 13.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide lyase Laminin_G_3 PF13385.1 CCF43865.1 - 0.043 14.0 1.3 0.083 13.1 0.9 1.6 1 1 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily Pro-kuma_activ PF09286.6 CCF43867.1 - 1.1e-48 164.9 0.1 3.3e-48 163.3 0.1 1.7 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain OAF PF14941.1 CCF43868.1 - 0.055 12.6 0.2 0.071 12.2 0.1 1.1 1 0 0 1 1 1 0 Transcriptional regulator, Out at first zf-AN1 PF01428.11 CCF43869.1 - 4e-12 45.7 8.6 4.5e-12 45.6 6.0 1.1 1 0 0 1 1 1 1 AN1-like Zinc finger TPR_10 PF13374.1 CCF43870.1 - 2.7e-32 109.7 0.1 4.3e-14 51.8 0.0 3.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 CCF43870.1 - 1.7e-28 98.3 0.0 8.1e-16 57.7 0.0 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 CCF43870.1 - 2e-13 49.0 0.1 0.0001 21.8 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 CCF43870.1 - 1.6e-07 30.9 0.2 0.022 14.9 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 CCF43870.1 - 1.8e-05 24.2 0.1 0.046 13.6 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 CCF43870.1 - 2.2e-05 23.8 0.0 0.048 13.2 0.0 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_4 PF07721.9 CCF43870.1 - 4.6e-05 23.4 0.0 0.18 12.3 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 CCF43870.1 - 0.00071 19.1 0.1 0.0054 16.3 0.1 2.2 2 1 0 2 2 2 1 TPR repeat TPR_8 PF13181.1 CCF43870.1 - 0.0036 16.9 0.0 0.51 10.2 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 CCF43870.1 - 0.0044 17.5 0.0 1.6 9.5 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 CCF43870.1 - 0.0099 16.5 0.0 0.27 11.9 0.0 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 CCF43870.1 - 0.037 14.3 0.0 0.13 12.6 0.0 1.7 1 1 1 2 2 2 0 Tetratricopeptide repeat PPR PF01535.15 CCF43870.1 - 0.048 13.6 0.1 2.3 8.4 0.0 2.3 2 0 0 2 2 2 0 PPR repeat DUF4074 PF13293.1 CCF43870.1 - 0.087 13.0 0.0 4.9 7.4 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4074) FATC PF02260.15 CCF43870.1 - 0.41 10.1 1.9 17 4.9 0.0 2.8 3 0 0 3 3 3 0 FATC domain FSH1 PF03959.8 CCF43873.1 - 2.2e-31 109.0 0.0 2.8e-30 105.3 0.0 1.9 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.2 CCF43873.1 - 0.00023 21.1 0.1 0.21 11.4 0.0 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 CCF43873.1 - 0.00032 20.2 0.0 0.0006 19.3 0.0 1.4 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 CCF43873.1 - 0.00078 19.2 0.0 0.0012 18.6 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Laminin_II PF06009.7 CCF43874.1 - 0.043 13.5 0.4 0.073 12.8 0.3 1.3 1 1 0 1 1 1 0 Laminin Domain II Fzo_mitofusin PF04799.8 CCF43874.1 - 0.099 12.0 1.2 0.2 11.0 0.4 1.6 1 1 1 2 2 2 0 fzo-like conserved region RPW8 PF05659.6 CCF43874.1 - 0.1 12.1 0.2 0.4 10.2 0.0 1.8 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 TMF_TATA_bd PF12325.3 CCF43874.1 - 0.15 11.7 1.6 4.7 6.9 0.2 2.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF221 PF02714.10 CCF43875.1 - 3e-102 341.8 28.8 3e-102 341.8 20.0 1.6 2 0 0 2 2 2 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 CCF43875.1 - 9.4e-30 103.2 1.0 9.4e-30 103.2 0.7 3.3 5 0 0 5 5 5 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 CCF43875.1 - 6.5e-29 99.6 0.2 3.5e-28 97.3 0.1 2.1 2 0 0 2 2 2 1 Phosphate metabolism protein DUF4463 PF14703.1 CCF43875.1 - 1.8e-22 79.6 0.3 2.9e-22 78.9 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) TPR_MLP1_2 PF07926.7 CCF43877.1 - 0.2 11.4 8.8 0.52 10.0 6.1 1.7 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein IncA PF04156.9 CCF43877.1 - 1.6 8.2 13.1 3.1 7.3 9.1 1.4 1 0 0 1 1 1 0 IncA protein APG6 PF04111.7 CCF43877.1 - 3.6 6.5 8.0 5.8 5.8 5.5 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 DZR PF12773.2 CCF43878.1 - 0.02 14.7 2.6 0.052 13.3 1.8 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.1 CCF43878.1 - 0.22 10.7 2.3 0.69 9.1 1.6 1.9 1 0 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 CCF43878.1 - 0.6 9.6 4.2 1.9 8.0 2.9 1.8 1 0 0 1 1 1 0 zinc-ribbon domain LicD PF04991.8 CCF43879.1 - 2.4e-29 102.9 5.3 6.9e-28 98.1 3.7 2.1 1 1 0 1 1 1 1 LicD family AphA_like PF14557.1 CCF43879.1 - 0.16 11.4 0.2 0.26 10.8 0.2 1.3 1 0 0 1 1 1 0 Putative AphA-like transcriptional regulator NUDIX PF00293.23 CCF43880.1 - 5.5e-08 32.5 0.2 8.3e-08 31.9 0.1 1.4 1 1 0 1 1 1 1 NUDIX domain CFEM PF05730.6 CCF43881.1 - 0.00034 20.3 3.1 0.00034 20.3 2.1 2.7 2 0 0 2 2 2 1 CFEM domain CFEM PF05730.6 CCF43882.1 - 0.1 12.4 0.3 0.24 11.2 0.2 1.6 1 0 0 1 1 1 0 CFEM domain OMPdecase PF00215.19 CCF43883.1 - 2.4e-99 331.2 0.0 2.9e-99 331.0 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family polyprenyl_synt PF00348.12 CCF43884.1 - 5.3e-30 104.1 0.2 6.5e-30 103.8 0.2 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Terpene_synth_C PF03936.11 CCF43884.1 - 0.027 13.6 0.1 0.032 13.4 0.0 1.1 1 0 0 1 1 1 0 Terpene synthase family, metal binding domain Condensation PF00668.15 CCF43885.1 - 7.6e-38 130.0 0.5 3.3e-25 88.5 0.0 2.4 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.20 CCF43885.1 - 4e-17 62.2 2.8 3.9e-08 33.4 0.2 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site DUF3337 PF11816.3 CCF43887.1 - 1.1e-90 304.4 0.2 1.8e-90 303.7 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) WW PF00397.21 CCF43888.1 - 9.4e-09 34.9 0.7 2.3e-08 33.7 0.0 2.1 2 0 0 2 2 2 1 WW domain PhoD PF09423.5 CCF43888.1 - 0.018 13.6 0.3 0.027 13.0 0.2 1.2 1 0 0 1 1 1 0 PhoD-like phosphatase PIG-F PF06699.6 CCF43889.1 - 0.23 11.3 4.5 1.9 8.3 3.1 2.0 1 1 0 1 1 1 0 GPI biosynthesis protein family Pig-F DUF3989 PF13150.1 CCF43889.1 - 0.97 8.9 4.9 0.22 11.0 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) Fungal_trans PF04082.13 CCF43890.1 - 2.2e-15 56.2 0.0 3.5e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF43890.1 - 5.5e-05 22.9 4.9 8.8e-05 22.3 3.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_15 PF00723.16 CCF43891.1 - 1.8e-84 283.8 0.0 2.3e-84 283.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.14 CCF43891.1 - 2.6e-22 78.2 0.3 8e-22 76.6 0.0 2.0 2 0 0 2 2 2 1 Starch binding domain p450 PF00067.17 CCF43892.1 - 1.9e-50 171.7 0.0 2.7e-50 171.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_23 PF13489.1 CCF43893.1 - 1.1e-19 70.6 0.0 1.6e-19 70.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF43893.1 - 3.9e-09 37.0 0.1 1.5e-07 31.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF43893.1 - 6.4e-07 29.0 0.0 1e-05 25.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF43893.1 - 1.3e-06 28.8 0.0 1.2e-05 25.7 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF43893.1 - 4.6e-06 27.0 0.0 1.1e-05 25.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF43893.1 - 0.00024 21.4 0.0 0.0009 19.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 CCF43893.1 - 0.0011 18.1 0.0 0.0025 16.9 0.0 1.6 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.9 CCF43893.1 - 0.0016 17.8 0.0 0.0046 16.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain FtsJ PF01728.14 CCF43893.1 - 0.0058 16.6 0.0 0.0089 16.0 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.12 CCF43893.1 - 0.0083 15.1 0.0 0.015 14.3 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase FmrO PF07091.6 CCF43893.1 - 0.024 13.6 0.0 0.045 12.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Methyltransf_26 PF13659.1 CCF43893.1 - 0.071 13.1 0.1 0.13 12.2 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain PrmA PF06325.8 CCF43893.1 - 0.14 11.2 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.13 CCF43893.1 - 0.15 11.1 0.0 0.79 8.7 0.0 2.0 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Microtub_assoc PF07989.6 CCF43894.1 - 3.3e-28 97.3 4.3 3.3e-28 97.3 3.0 14.0 10 5 5 16 16 16 1 Microtubule associated PACT_coil_coil PF10495.4 CCF43894.1 - 6.7e-11 41.9 0.4 2.7e-10 40.0 0.3 2.2 1 0 0 1 1 1 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein TPR_MLP1_2 PF07926.7 CCF43894.1 - 0.00035 20.3 225.6 0.0061 16.3 12.9 12.4 4 2 4 10 10 10 6 TPR/MLP1/MLP2-like protein HALZ PF02183.13 CCF43894.1 - 0.00081 19.0 2.7 0.00081 19.0 1.9 15.7 15 2 3 18 18 18 2 Homeobox associated leucine zipper AAA_13 PF13166.1 CCF43894.1 - 0.0027 16.2 26.6 0.0027 16.2 18.5 6.8 1 1 7 8 8 8 5 AAA domain CCDC155 PF14662.1 CCF43894.1 - 0.0034 16.9 24.6 0.0034 16.9 17.0 10.7 1 1 8 10 10 10 1 Coiled-coil region of CCDC155 DUF1664 PF07889.7 CCF43894.1 - 0.0043 16.8 7.2 0.0043 16.8 5.0 12.8 2 1 10 15 15 15 1 Protein of unknown function (DUF1664) Reo_sigmaC PF04582.7 CCF43894.1 - 0.25 10.4 74.2 0.097 11.8 0.9 8.8 3 3 5 9 9 9 0 Reovirus sigma C capsid protein Peptidase_C14 PF00656.17 CCF43895.1 - 2.4e-59 201.0 0.0 3.1e-59 200.6 0.0 1.1 1 0 0 1 1 1 1 Caspase domain PAT1 PF09770.4 CCF43895.1 - 9.4 4.3 13.6 11 4.0 9.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Nha1_C PF08619.5 CCF43898.1 - 1.4e-78 265.1 28.6 2e-78 264.6 19.8 1.1 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.16 CCF43898.1 - 9.7e-05 21.0 0.8 0.00012 20.7 0.6 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family FlgD_ig PF13860.1 CCF43898.1 - 0.026 14.2 0.2 0.13 12.0 0.0 2.2 2 0 0 2 2 2 0 FlgD Ig-like domain Glyco_hydro_3_C PF01915.17 CCF43899.1 - 2.5e-54 184.1 0.1 3.8e-54 183.6 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.16 CCF43899.1 - 9.9e-35 119.9 0.0 1.4e-34 119.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.1 CCF43899.1 - 1.7e-24 85.5 0.1 5.3e-24 83.9 0.0 1.9 2 0 0 2 2 2 1 Fibronectin type III-like domain Pyr_redox_2 PF07992.9 CCF43900.1 - 4.2e-31 108.4 0.0 6.3e-31 107.8 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF43900.1 - 2.4e-14 53.4 0.0 7.3e-12 45.5 0.0 3.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF43900.1 - 1.4e-09 38.3 0.0 0.022 14.8 0.0 3.2 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF43900.1 - 0.0098 15.9 0.0 6.2 6.9 0.0 2.8 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Methyltransf_23 PF13489.1 CCF43901.1 - 5.9e-17 61.8 0.0 7.9e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF43901.1 - 2.8e-06 26.9 0.0 2.4e-05 23.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF43901.1 - 5.6e-06 26.9 0.1 0.00011 22.7 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF43901.1 - 9.4e-05 22.8 0.0 0.00016 22.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF43901.1 - 0.0037 17.6 0.0 0.035 14.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 CCF43901.1 - 0.015 15.2 0.1 0.027 14.4 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase PTS_2-RNA PF01885.11 CCF43901.1 - 0.15 11.3 0.0 0.24 10.6 0.0 1.3 1 0 0 1 1 1 0 RNA 2'-phosphotransferase, Tpt1 / KptA family CopD PF05425.8 CCF43902.1 - 0.0024 18.0 3.0 0.57 10.4 0.3 2.2 2 0 0 2 2 2 2 Copper resistance protein D MFS_1 PF07690.11 CCF43902.1 - 0.01 14.5 4.5 0.014 14.1 3.2 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily Herpes_glycop PF01528.11 CCF43902.1 - 0.027 13.1 5.1 1.2 7.7 1.2 2.0 1 1 1 2 2 2 0 Herpesvirus glycoprotein M 7tm_7 PF08395.7 CCF43902.1 - 0.097 11.6 7.7 0.15 11.0 5.3 1.3 1 0 0 1 1 1 0 7tm Chemosensory receptor Cyto_ox_2 PF02322.10 CCF43902.1 - 0.12 11.4 5.1 0.22 10.6 3.5 1.3 1 1 0 1 1 1 0 Cytochrome oxidase subunit II DUF4131 PF13567.1 CCF43902.1 - 0.14 11.5 5.2 1.4 8.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Neur_chan_memb PF02932.11 CCF43902.1 - 0.17 11.7 0.0 0.17 11.7 0.0 2.0 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region DUF4239 PF14023.1 CCF43902.1 - 0.3 10.3 2.1 3.4 6.9 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4239) DUF1673 PF07895.6 CCF43902.1 - 3.2 7.2 6.8 6 6.3 4.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1673) DUF2029 PF09594.5 CCF43902.1 - 5.3 6.4 11.3 0.86 9.0 1.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2029) Acyl_transf_1 PF00698.16 CCF43903.1 - 7.9e-29 100.9 0.0 1.1e-28 100.5 0.0 1.1 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.1 CCF43903.1 - 0.00069 18.8 0.0 0.002 17.3 0.0 1.7 1 0 0 1 1 1 1 Polyketide synthase dehydratase WD40 PF00400.27 CCF43905.1 - 1.8e-05 24.3 0.0 0.00034 20.3 0.0 2.2 2 0 0 2 2 2 1 WD domain, G-beta repeat DNA_topoisoIV PF00521.15 CCF43907.1 - 1.5e-123 412.7 0.8 1.5e-122 409.5 0.0 2.2 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseB PF00204.20 CCF43907.1 - 2.1e-33 114.9 3.4 4.7e-33 113.8 2.4 1.6 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.17 CCF43907.1 - 7.7e-13 48.2 0.0 4.2e-12 45.9 0.0 2.3 1 0 0 1 1 1 1 Toprim domain HATPase_c PF02518.21 CCF43907.1 - 6e-11 42.0 0.0 1.9e-10 40.4 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Reticulon PF02453.12 CCF43908.1 - 1.7e-38 131.8 1.2 2.5e-38 131.3 0.8 1.2 1 0 0 1 1 1 1 Reticulon DUF3328 PF11807.3 CCF43909.1 - 6.6e-09 35.7 0.0 7.5e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Pox_A14 PF05767.7 CCF43909.1 - 0.0068 16.3 0.1 0.009 15.9 0.1 1.2 1 0 0 1 1 1 1 Poxvirus virion envelope protein A14 S-AdoMet_synt_C PF02773.11 CCF43910.1 - 5e-51 172.0 1.1 9.8e-51 171.1 0.8 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 CCF43910.1 - 4.8e-47 158.8 0.0 8.4e-47 158.0 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.15 CCF43910.1 - 7.3e-42 141.6 0.3 1.7e-41 140.4 0.0 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain Dr_adhesin PF12393.3 CCF43911.1 - 0.11 12.6 1.2 0.38 10.8 0.8 2.0 1 0 0 1 1 1 0 Dr family adhesin Fungal_trans_2 PF11951.3 CCF43912.1 - 0.039 12.5 0.1 0.083 11.4 0.0 1.6 2 0 0 2 2 2 0 Fungal specific transcription factor domain Fungal_trans PF04082.13 CCF43913.1 - 5.2e-25 87.7 0.3 8.5e-25 87.0 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain ATP_transf PF09830.4 CCF43914.1 - 0.034 13.9 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 ATP adenylyltransferase Na_Ca_ex PF01699.19 CCF43915.1 - 1.3e-25 89.6 7.5 1.3e-25 89.6 5.2 3.2 2 1 1 3 3 3 2 Sodium/calcium exchanger protein UDPGT PF00201.13 CCF43916.1 - 2.3e-05 23.1 0.0 3.8e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase ATG_C PF09333.6 CCF43916.1 - 0.0012 18.9 0.0 0.0028 17.7 0.0 1.5 1 0 0 1 1 1 1 ATG C terminal domain Glyco_tran_28_C PF04101.11 CCF43916.1 - 0.0054 16.4 0.0 0.012 15.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain DUF4648 PF15505.1 CCF43916.1 - 0.023 14.9 1.8 0.028 14.6 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4648) Ribosomal_L29 PF00831.18 CCF43917.1 - 2.2e-19 68.8 1.8 2.2e-19 68.8 1.2 1.9 2 0 0 2 2 2 1 Ribosomal L29 protein DUF2450 PF10475.4 CCF43917.1 - 0.061 12.2 1.4 0.071 12.0 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) FlxA PF14282.1 CCF43917.1 - 1.9 8.4 5.0 1.7 8.6 3.0 1.3 1 1 0 1 1 1 0 FlxA-like protein V-SNARE_C PF12352.3 CCF43918.1 - 2.2e-12 46.8 0.5 2.2e-12 46.8 0.3 3.1 4 0 0 4 4 4 1 Snare region anchored in the vesicle membrane C-terminus STAT_alpha PF01017.15 CCF43918.1 - 0.084 12.5 7.3 2 8.1 1.9 2.5 1 1 1 2 2 2 0 STAT protein, all-alpha domain Imm3 PF14425.1 CCF43918.1 - 0.21 11.5 1.3 0.36 10.7 0.0 2.0 2 1 1 3 3 3 0 Immunity protein Imm3 IncA PF04156.9 CCF43918.1 - 1.9 8.0 12.5 1.1 8.8 6.7 1.8 1 1 1 2 2 2 0 IncA protein Fib_alpha PF08702.5 CCF43918.1 - 3.5 7.7 6.7 4.2 7.4 2.5 2.2 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family ATP-synt_10 PF05176.9 CCF43919.1 - 2.9e-84 282.2 0.0 3.7e-84 281.9 0.0 1.1 1 0 0 1 1 1 1 ATP10 protein 2-oxoacid_dh PF00198.18 CCF43920.1 - 6.3e-74 248.1 0.0 1.1e-73 247.3 0.0 1.4 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 CCF43920.1 - 5.9e-18 64.2 0.0 1e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 CCF43920.1 - 7.1e-11 41.5 0.1 1.7e-10 40.3 0.1 1.7 1 0 0 1 1 1 1 e3 binding domain BEX PF04538.7 CCF43920.1 - 0.092 12.9 2.3 0.36 11.0 0.0 2.2 2 0 0 2 2 2 0 Brain expressed X-linked like family SKI PF01202.17 CCF43921.1 - 1e-11 44.9 0.0 1.3e-11 44.6 0.0 1.1 1 0 0 1 1 1 1 Shikimate kinase AAA_17 PF13207.1 CCF43921.1 - 2.1e-10 41.4 0.0 3.8e-10 40.6 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CCF43921.1 - 5e-10 39.4 0.0 6.5e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CCF43921.1 - 2.5e-08 34.2 0.0 5.7e-08 33.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 CCF43921.1 - 4.7e-05 23.5 0.2 0.00015 21.9 0.0 1.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 CCF43921.1 - 5e-05 22.1 0.0 7.7e-05 21.5 0.0 1.2 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 CCF43921.1 - 0.00014 21.9 0.0 0.00024 21.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 CCF43921.1 - 0.0007 19.5 0.0 0.0019 18.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CCF43921.1 - 0.00097 18.8 0.0 0.0024 17.5 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain CoaE PF01121.15 CCF43921.1 - 0.0011 18.3 0.0 0.012 14.9 0.0 2.3 2 0 0 2 2 2 1 Dephospho-CoA kinase NACHT PF05729.7 CCF43921.1 - 0.0011 18.6 0.0 0.0019 17.8 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 CCF43921.1 - 0.0016 18.4 0.0 0.0026 17.7 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.17 CCF43921.1 - 0.0021 18.2 0.0 0.0042 17.2 0.0 1.5 1 0 0 1 1 1 1 RNA helicase PRK PF00485.13 CCF43921.1 - 0.0023 17.5 0.0 0.0066 16.0 0.0 1.7 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_5 PF07728.9 CCF43921.1 - 0.0026 17.4 0.0 0.0048 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 CCF43921.1 - 0.0041 17.0 0.0 0.011 15.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.1 CCF43921.1 - 0.0065 16.4 0.0 0.039 13.8 0.0 2.0 1 1 2 3 3 3 1 Cytidylate kinase-like family AAA_30 PF13604.1 CCF43921.1 - 0.0097 15.5 0.1 0.021 14.4 0.0 1.5 2 0 0 2 2 1 1 AAA domain ABC_tran PF00005.22 CCF43921.1 - 0.015 15.6 0.0 0.026 14.8 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Mg_chelatase PF01078.16 CCF43921.1 - 0.016 14.3 0.1 0.058 12.5 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI APS_kinase PF01583.15 CCF43921.1 - 0.027 14.1 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase Thymidylate_kin PF02223.12 CCF43921.1 - 0.027 13.8 0.0 4.8 6.5 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase T2SE PF00437.15 CCF43921.1 - 0.043 12.7 0.0 0.076 11.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.11 CCF43921.1 - 0.062 12.5 0.1 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein NTPase_1 PF03266.10 CCF43921.1 - 0.062 13.0 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 NTPase MobB PF03205.9 CCF43921.1 - 0.07 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B RuvB_N PF05496.7 CCF43921.1 - 0.077 12.0 0.2 0.19 10.7 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus Zeta_toxin PF06414.7 CCF43921.1 - 0.1 11.6 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.1 CCF43921.1 - 0.14 11.7 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 CCF43921.1 - 0.14 11.8 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase DNA_pol3_delta2 PF13177.1 CCF43921.1 - 0.16 11.5 0.0 0.23 11.1 0.0 1.3 1 1 0 1 1 1 0 DNA polymerase III, delta subunit YIF1 PF03878.10 CCF43922.1 - 7.6e-76 254.4 1.4 8.5e-76 254.2 1.0 1.0 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.12 CCF43922.1 - 0.38 10.2 14.9 0.15 11.5 7.9 1.9 1 1 1 2 2 2 0 Yip1 domain Myelin_PLP PF01275.14 CCF43923.1 - 0.011 15.1 0.0 0.012 14.9 0.0 1.0 1 0 0 1 1 1 0 Myelin proteolipid protein (PLP or lipophilin) UCR_6-4kD PF08997.5 CCF43923.1 - 0.037 13.7 0.0 0.056 13.1 0.0 1.3 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein GCFC PF07842.7 CCF43924.1 - 7.2e-69 232.2 2.6 9.7e-69 231.7 1.8 1.1 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein UCH PF00443.24 CCF43925.1 - 4.9e-41 140.6 0.0 8.8e-35 120.1 0.0 2.8 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CCF43925.1 - 7.7e-15 55.0 0.6 7.9e-11 41.9 0.0 3.2 2 2 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Kelch_3 PF13415.1 CCF43926.1 - 2.9e-26 90.9 8.9 2.4e-08 33.9 0.0 5.4 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_4 PF13418.1 CCF43926.1 - 7.2e-21 73.6 9.4 8e-06 25.5 0.0 6.0 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_5 PF13854.1 CCF43926.1 - 2.1e-19 69.0 3.1 1.2e-07 31.5 0.0 5.3 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 CCF43926.1 - 1.8e-14 52.8 4.7 0.0027 17.3 0.0 6.2 6 1 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 CCF43926.1 - 1e-11 44.4 1.3 0.00057 19.9 0.1 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.20 CCF43926.1 - 3e-11 42.6 0.1 0.00013 21.4 0.0 4.7 4 0 0 4 4 4 3 Kelch motif DENN PF02141.16 CCF43931.1 - 2.2e-57 193.7 0.0 3.5e-57 193.1 0.0 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.14 CCF43931.1 - 5.4e-18 64.8 0.2 1e-17 63.9 0.1 1.5 1 0 0 1 1 1 1 dDENN domain uDENN PF03456.13 CCF43931.1 - 3.9e-17 61.9 0.0 7.7e-17 61.0 0.0 1.5 1 0 0 1 1 1 1 uDENN domain C1_1 PF00130.17 CCF43931.1 - 0.00062 19.4 8.3 0.0014 18.3 5.7 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.24 CCF43931.1 - 0.058 13.1 6.6 0.091 12.4 4.0 1.8 1 1 0 1 1 1 0 PHD-finger C1_3 PF07649.7 CCF43931.1 - 0.12 12.4 6.1 0.25 11.4 4.2 1.6 1 0 0 1 1 1 0 C1-like domain C1_2 PF03107.11 CCF43931.1 - 0.58 10.3 6.4 1.4 9.1 4.3 1.8 2 0 0 2 2 2 0 C1 domain OrfB_Zn_ribbon PF07282.6 CCF43931.1 - 2.3 7.9 5.1 6.1 6.5 3.5 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain SNAP PF14938.1 CCF43932.1 - 8.6e-115 382.7 15.7 9.7e-115 382.5 10.9 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 CCF43932.1 - 7e-06 25.8 14.1 0.0094 15.8 2.6 3.5 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 CCF43932.1 - 9.4e-06 25.1 13.8 0.43 10.6 0.1 6.1 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.1 CCF43932.1 - 5.9e-05 23.6 18.8 0.003 18.1 0.1 4.0 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 CCF43932.1 - 0.0015 18.1 18.2 0.0058 16.2 1.6 3.9 1 1 3 4 4 4 2 TPR repeat TPR_7 PF13176.1 CCF43932.1 - 0.0027 17.3 10.4 2 8.4 0.2 5.1 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.1 CCF43932.1 - 0.0027 18.0 12.3 25 5.6 0.0 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 CCF43932.1 - 0.0072 16.0 8.8 2 8.3 0.4 4.7 4 1 0 4 4 4 2 Tetratricopeptide repeat Exotox-A_target PF09102.5 CCF43932.1 - 0.089 12.3 0.2 0.21 11.0 0.1 1.7 2 0 0 2 2 2 0 Exotoxin A, targeting TPR_14 PF13428.1 CCF43932.1 - 0.36 11.5 17.4 17 6.4 0.3 5.5 2 1 4 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.1 CCF43932.1 - 0.46 10.8 0.1 0.46 10.8 0.1 3.9 2 2 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 CCF43932.1 - 0.55 9.9 18.0 0.4 10.3 0.2 5.2 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_9 PF13371.1 CCF43932.1 - 1.1 9.1 6.3 1 9.2 0.4 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Glu-tRNAGln PF02686.10 CCF43933.1 - 0.00052 19.7 0.1 0.0022 17.7 0.1 2.0 1 1 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit DUF726 PF05277.7 CCF43934.1 - 6.2e-123 410.0 4.6 7.6e-123 409.7 3.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Gate PF07670.9 CCF43934.1 - 0.039 13.8 0.2 3.7 7.4 0.7 2.7 2 1 0 2 2 2 0 Nucleoside recognition Abhydrolase_6 PF12697.2 CCF43934.1 - 0.068 13.0 0.1 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Methyltransf_23 PF13489.1 CCF43935.1 - 2.4e-13 50.1 0.0 3.6e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF43935.1 - 1.8e-07 30.8 0.0 0.00025 20.6 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 CCF43935.1 - 1.8e-05 25.2 0.0 0.00016 22.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF43935.1 - 2.1e-05 24.8 0.4 0.00034 21.0 0.0 2.7 2 2 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF43935.1 - 5.6e-05 23.5 0.0 0.00013 22.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF43935.1 - 0.0014 17.7 0.0 0.0021 17.1 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.14 CCF43935.1 - 0.0037 17.2 0.0 0.005 16.8 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_25 PF13649.1 CCF43935.1 - 0.015 15.6 0.0 0.085 13.2 0.0 2.2 2 1 0 2 2 2 0 Methyltransferase domain CMAS PF02353.15 CCF43935.1 - 0.015 14.4 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MTS PF05175.9 CCF43935.1 - 0.022 14.1 0.0 0.042 13.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.8 CCF43935.1 - 0.038 13.1 0.0 0.059 12.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.4 CCF43935.1 - 0.06 12.7 0.0 0.081 12.3 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Ubie_methyltran PF01209.13 CCF43935.1 - 0.11 11.6 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family GidB PF02527.10 CCF43935.1 - 0.16 11.0 0.0 0.83 8.7 0.0 1.9 2 0 0 2 2 2 0 rRNA small subunit methyltransferase G POT1 PF02765.12 CCF43936.1 - 1.4e-09 37.9 0.0 4.1e-09 36.5 0.0 1.7 2 0 0 2 2 2 1 Telomeric single stranded DNA binding POT1/CDC13 DivIVA PF05103.8 CCF43936.1 - 0.018 15.1 6.5 0.035 14.1 4.5 1.4 1 0 0 1 1 1 0 DivIVA protein Borrelia_P83 PF05262.6 CCF43936.1 - 1.3 7.1 11.6 2 6.6 8.1 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Bcr-Abl_Oligo PF09036.5 CCF43937.1 - 1.4 8.8 5.9 6.3 6.8 0.1 2.5 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain Ndufs5 PF10200.4 CCF43937.1 - 1.8 8.5 6.2 0.18 11.8 0.6 2.1 2 0 0 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa adh_short PF00106.20 CCF43938.1 - 0.00097 19.0 0.2 0.0013 18.6 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Peptidase_M19 PF01244.16 CCF43939.1 - 0.012 14.5 0.3 0.019 13.9 0.2 1.2 1 0 0 1 1 1 0 Membrane dipeptidase (Peptidase family M19) COG7 PF10191.4 CCF43939.1 - 0.018 13.0 0.2 0.022 12.6 0.2 1.1 1 0 0 1 1 1 0 Golgi complex component 7 (COG7) Mod_r PF07200.8 CCF43939.1 - 0.032 14.1 1.6 0.054 13.4 1.1 1.3 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein NOA36 PF06524.7 CCF43939.1 - 0.34 10.1 7.2 0.67 9.1 5.0 1.5 1 0 0 1 1 1 0 NOA36 protein HET PF06985.6 CCF43940.1 - 1.8e-16 60.5 0.4 6e-16 58.8 0.0 1.8 1 1 1 2 2 2 1 Heterokaryon incompatibility protein (HET) MFS_1 PF07690.11 CCF43941.1 - 4.7e-13 48.5 22.6 6.3e-13 48.1 15.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sulfatase PF00884.18 CCF43942.1 - 1.9e-65 221.0 0.7 2.7e-65 220.5 0.5 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.17 CCF43942.1 - 9.1e-05 21.9 0.3 0.021 14.1 0.0 2.1 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Glyco_hydro_92 PF07971.7 CCF43943.1 - 7.4e-167 555.9 0.0 9.4e-167 555.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 DTHCT PF08070.6 CCF43946.1 - 0.12 13.0 0.8 0.14 12.7 0.6 1.1 1 0 0 1 1 1 0 DTHCT (NUC029) region SR-25 PF10500.4 CCF43946.1 - 0.16 11.4 9.5 0.19 11.1 6.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Peptidase_S10 PF00450.17 CCF43947.1 - 1.9e-111 373.1 0.1 2.3e-111 372.9 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase eIF-3_zeta PF05091.7 CCF43948.1 - 0.011 14.4 0.5 0.013 14.1 0.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4647 PF15504.1 CCF43948.1 - 0.014 14.2 0.1 0.018 13.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) TatD_DNase PF01026.16 CCF43949.1 - 1.3e-27 96.5 0.0 2e-27 96.0 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase DUF4586 PF15239.1 CCF43951.1 - 0.036 13.6 0.1 0.044 13.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4586) Herpes_UL56 PF04534.7 CCF43951.1 - 0.14 11.9 3.0 0.15 11.7 2.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL56 protein UbiA PF01040.13 CCF43952.1 - 1.8e-33 115.8 16.3 2.3e-33 115.5 11.3 1.0 1 0 0 1 1 1 1 UbiA prenyltransferase family Ribosom_S12_S23 PF00164.20 CCF43953.1 - 1.2e-12 47.3 0.1 1.3e-12 47.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 ABM PF03992.11 CCF43954.1 - 2.2e-06 27.6 0.1 0.014 15.4 0.0 2.4 2 0 0 2 2 2 2 Antibiotic biosynthesis monooxygenase DUF3764 PF12594.3 CCF43954.1 - 0.025 14.3 0.0 0.039 13.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3764) PLA2_B PF01735.13 CCF43957.1 - 1.2e-27 96.2 0.0 2.7e-27 95.1 0.0 1.5 1 1 0 1 1 1 1 Lysophospholipase catalytic domain Ribonucleas_3_3 PF14622.1 CCF43958.1 - 2.9e-05 24.0 0.0 0.15 12.0 0.0 2.3 2 0 0 2 2 2 2 Ribonuclease-III-like dsrm PF00035.20 CCF43958.1 - 0.00033 21.1 0.0 0.00067 20.1 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.21 CCF43958.1 - 0.00044 20.6 0.0 0.0012 19.2 0.0 1.8 1 1 0 1 1 1 1 Ribonuclease III domain Vac_ImportDeg PF09783.4 CCF43960.1 - 2.4e-65 219.3 0.5 1.3e-50 171.3 0.4 2.1 2 0 0 2 2 2 2 Vacuolar import and degradation protein RgpF PF05045.7 CCF43961.1 - 0.00043 18.9 0.1 0.38 9.2 0.0 2.1 2 0 0 2 2 2 2 Rhamnan synthesis protein F MFS_1 PF07690.11 CCF43963.1 - 3.5e-05 22.6 22.2 0.00042 19.1 9.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily zf-SAP30 PF13866.1 CCF43964.1 - 0.24 11.0 2.3 0.36 10.5 1.6 1.4 1 0 0 1 1 1 0 SAP30 zinc-finger Abhydrolase_3 PF07859.8 CCF43966.1 - 4.1e-09 36.3 0.0 6.6e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold RVT_2 PF07727.9 CCF43967.1 - 5e-10 38.7 0.0 8.6e-10 37.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 CCF43967.1 - 2.3e-08 34.1 0.0 4.7e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain 5_nucleotid_C PF02872.13 CCF43968.1 - 1.4e-34 119.3 0.6 2.7e-34 118.3 0.4 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.23 CCF43968.1 - 9.6e-13 47.9 0.4 2.3e-10 40.2 0.4 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase YmdB PF13277.1 CCF43968.1 - 0.023 13.7 0.0 0.036 13.1 0.0 1.4 1 0 0 1 1 1 0 YmdB-like protein Cu-oxidase_2 PF07731.9 CCF43969.1 - 2.1e-32 111.5 0.8 2.1e-32 111.5 0.6 1.8 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.17 CCF43969.1 - 3.8e-06 26.8 0.1 5.3e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Multicopper oxidase UPF0220 PF05255.6 CCF43970.1 - 0.026 13.7 0.0 0.045 12.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0220) Transp_cyt_pur PF02133.10 CCF43971.1 - 2e-19 69.4 1.0 2.3e-19 69.2 0.7 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin NnrS PF05940.7 CCF43971.1 - 0.11 11.3 1.9 0.14 10.9 1.3 1.1 1 0 0 1 1 1 0 NnrS protein Permease PF02405.11 CCF43971.1 - 0.13 11.7 0.9 0.15 11.4 0.6 1.1 1 0 0 1 1 1 0 Permease Fungal_trans PF04082.13 CCF43972.1 - 6.8e-15 54.6 0.0 1.5e-14 53.5 0.0 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain UbiD PF01977.11 CCF43973.1 - 1.1e-131 439.1 0.0 1.3e-131 438.8 0.0 1.1 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase MarR_2 PF12802.2 CCF43973.1 - 0.14 11.8 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 MarR family CHZ PF09649.5 CCF43974.1 - 2.5e-17 61.8 0.6 2.5e-17 61.8 0.4 1.9 2 0 0 2 2 2 1 Histone chaperone domain CHZ TAP42 PF04177.7 CCF43974.1 - 3.8 6.3 6.2 4 6.2 4.3 1.0 1 0 0 1 1 1 0 TAP42-like family Zip PF02535.17 CCF43976.1 - 4.2e-55 186.9 0.1 4.8e-55 186.7 0.1 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter SIR2 PF02146.12 CCF43977.1 - 6.4e-23 81.3 0.0 7.1e-12 45.4 0.0 2.1 2 0 0 2 2 2 2 Sir2 family PhnA_Zn_Ribbon PF08274.7 CCF43977.1 - 0.13 12.0 1.1 0.24 11.2 0.8 1.4 1 0 0 1 1 1 0 PhnA Zinc-Ribbon MFS_1 PF07690.11 CCF43978.1 - 1.4e-15 56.8 17.5 1.4e-15 56.8 12.2 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Glyco_transf_52 PF07922.6 CCF43978.1 - 0.0015 17.6 0.0 0.0022 17.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 52 DUF4337 PF14235.1 CCF43978.1 - 0.14 11.9 0.3 0.39 10.5 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF3357 PF11837.3 CCF43978.1 - 0.16 11.8 0.9 1.9 8.3 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3357) FAR1 PF03101.10 CCF43979.1 - 1.3e-05 25.6 0.0 3.1e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 FAR1 DNA-binding domain Phosphodiest PF01663.17 CCF43979.1 - 0.00015 21.2 0.2 0.00031 20.1 0.1 1.5 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4200 PF13863.1 CCF43979.1 - 0.057 13.3 10.0 0.11 12.4 7.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DUF4071 PF13281.1 CCF43979.1 - 0.13 11.0 0.6 0.18 10.5 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4071) TPD52 PF04201.10 CCF43979.1 - 0.57 9.9 2.9 0.97 9.1 2.0 1.3 1 0 0 1 1 1 0 Tumour protein D52 family Peptidase_M28 PF04389.12 CCF43980.1 - 3.5e-20 72.4 0.0 4.9e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 adh_short PF00106.20 CCF43981.1 - 1.2e-21 77.3 2.5 1.7e-21 76.8 1.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF43981.1 - 3.2e-13 50.0 0.0 4e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 CCF43981.1 - 4.7e-10 39.7 1.3 2.7e-09 37.2 0.5 2.3 2 1 0 2 2 2 1 NADH(P)-binding KR PF08659.5 CCF43981.1 - 1.4e-08 34.6 0.2 2e-08 34.1 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF43981.1 - 2.4e-05 23.8 0.1 3.1e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 CCF43981.1 - 0.006 15.8 0.1 0.0093 15.2 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family ADH_zinc_N PF00107.21 CCF43981.1 - 0.0094 15.4 1.3 0.014 14.9 0.1 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DFP PF04127.10 CCF43981.1 - 0.011 15.3 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Eno-Rase_NADH_b PF12242.3 CCF43981.1 - 0.022 14.5 0.1 0.062 13.0 0.1 1.7 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase M20_dimer PF07687.9 CCF43982.1 - 9.3e-21 73.6 0.1 1.5e-20 73.0 0.1 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.23 CCF43982.1 - 1.6e-09 37.5 0.0 2e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 PAH PF02671.16 CCF43983.1 - 0.0014 18.1 0.0 0.0024 17.4 0.0 1.6 1 1 0 1 1 1 1 Paired amphipathic helix repeat HopW1-1 PF15457.1 CCF43983.1 - 0.04 12.9 0.1 0.049 12.6 0.0 1.1 1 0 0 1 1 1 0 Type III T3SS secreted effector HopW1-1/HopPmaA Phage_GPO PF05929.6 CCF43983.1 - 0.059 12.6 0.2 0.066 12.4 0.1 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase HATPase_c PF02518.21 CCF43984.1 - 1.4e-20 73.1 0.0 2.5e-20 72.2 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 CCF43984.1 - 8.2e-17 61.2 0.0 9.8e-16 57.7 0.0 2.3 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.20 CCF43984.1 - 1.5e-10 40.8 0.0 3.6e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Cullin PF00888.17 CCF43985.1 - 2.8e-202 673.4 9.5 3.8e-202 672.9 6.6 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 CCF43985.1 - 7.7e-27 92.9 5.5 7.7e-27 92.9 3.8 2.7 3 0 0 3 3 3 1 Cullin protein neddylation domain WGG PF10273.4 CCF43985.1 - 0.56 10.3 3.3 14 5.8 0.0 3.8 4 0 0 4 4 4 0 Pre-rRNA-processing protein TSR2 GDPD_2 PF13653.1 CCF43986.1 - 2.4 8.4 4.0 33 4.8 0.2 2.3 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family PBP1_TM PF14812.1 CCF43988.1 - 0.0033 17.7 0.4 0.0033 17.7 0.3 2.1 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal OPT PF03169.10 CCF43989.1 - 4.1e-103 345.9 10.8 5.1e-103 345.6 7.5 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Sugar_tr PF00083.19 CCF43990.1 - 1.9e-36 125.6 13.9 2.1e-36 125.4 9.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF43990.1 - 1e-05 24.4 19.6 1.3e-05 24.0 13.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Ni_hydr_CYTB PF01292.15 CCF43990.1 - 1.3 8.4 6.5 2.8 7.3 4.4 1.8 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 FUSC PF04632.7 CCF43990.1 - 2.8 6.2 10.8 0.72 8.2 0.6 2.1 2 0 0 2 2 2 0 Fusaric acid resistance protein family Trep_Strep PF09605.5 CCF43990.1 - 5.5 6.6 16.9 0.098 12.3 1.7 2.5 2 1 0 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) tRNA-synt_1c PF00749.16 CCF43992.1 - 3.4e-65 219.7 0.0 4.4e-65 219.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 CCF43992.1 - 4.1e-32 111.2 0.1 6.1e-31 107.4 0.0 2.6 3 0 0 3 3 3 1 tRNA synthetases class I (E and Q), anti-codon binding domain ADK PF00406.17 CCF43993.1 - 2.9e-08 33.7 0.0 3.7e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase Thymidylate_kin PF02223.12 CCF43993.1 - 0.0027 17.0 0.0 0.0046 16.3 0.0 1.4 1 0 0 1 1 1 1 Thymidylate kinase MFS_1 PF07690.11 CCF43994.1 - 7.6e-06 24.8 7.4 9.6e-06 24.5 5.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily PseudoU_synth_1 PF01416.15 CCF43995.1 - 2.5e-26 92.1 0.0 8.7e-19 67.9 0.0 2.5 2 0 0 2 2 2 2 tRNA pseudouridine synthase SAND PF01342.16 CCF43995.1 - 0.078 12.7 0.2 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 SAND domain PIG-H PF10181.4 CCF43996.1 - 5.3e-27 93.2 0.0 7.8e-27 92.7 0.0 1.2 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component DUF1180 PF06679.7 CCF43996.1 - 0.12 12.2 1.2 0.16 11.8 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) MFS_1 PF07690.11 CCF43997.1 - 2.5e-41 141.5 47.5 7.5e-41 140.0 33.0 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF43997.1 - 1.5e-11 43.2 10.2 1.5e-11 43.2 7.1 1.5 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 CCF43997.1 - 9.9e-07 27.6 32.7 7.3e-06 24.8 9.3 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter DUF2919 PF11143.3 CCF43997.1 - 0.013 15.2 1.6 6.8 6.5 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2919) FSH1 PF03959.8 CCF43998.1 - 3.9e-32 111.4 0.0 5.1e-32 111.0 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 CCF43998.1 - 0.057 13.1 0.0 0.11 12.2 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family ADH_N PF08240.7 CCF43999.1 - 8.9e-09 35.0 0.0 1.8e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF43999.1 - 1.4e-08 34.2 0.0 2.6e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF43999.1 - 2e-05 25.5 0.0 5.9e-05 23.9 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Uso1_p115_C PF04871.8 CCF44000.1 - 0.02 14.8 0.6 0.025 14.4 0.4 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region 2H-phosphodiest PF08975.5 CCF44000.1 - 0.036 13.8 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1868) HTH_22 PF13309.1 CCF44000.1 - 0.089 12.5 0.3 0.55 10.0 0.0 2.2 3 0 0 3 3 3 0 HTH domain GCS2 PF04107.8 CCF44000.1 - 0.11 11.5 0.6 1.6 7.7 0.1 2.0 1 1 1 2 2 2 0 Glutamate-cysteine ligase family 2(GCS2) Syndecan PF01034.15 CCF44001.1 - 0.00097 18.7 0.9 0.0019 17.8 0.6 1.4 1 0 0 1 1 1 1 Syndecan domain MGC-24 PF05283.6 CCF44001.1 - 0.0033 17.2 9.1 0.006 16.3 6.3 1.3 1 0 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24) Herpes_gE PF02480.11 CCF44001.1 - 0.0045 15.3 0.1 0.0066 14.7 0.1 1.2 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E Podoplanin PF05808.6 CCF44001.1 - 0.0052 16.3 1.0 0.0082 15.7 0.7 1.2 1 0 0 1 1 1 1 Podoplanin SKG6 PF08693.5 CCF44001.1 - 0.16 11.3 3.8 0.27 10.5 2.6 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain TrbL PF04610.9 CCF44001.1 - 0.25 11.0 3.3 0.36 10.4 2.3 1.2 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein KGG PF10685.4 CCF44002.1 - 1.6e-25 88.4 20.2 2.8e-10 39.8 0.3 3.1 3 0 0 3 3 3 3 Stress-induced bacterial acidophilic repeat motif LEA_5 PF00477.12 CCF44002.1 - 0.13 12.4 4.1 0.21 11.9 2.9 1.4 1 1 0 1 1 1 0 Small hydrophilic plant seed protein DDE_1 PF03184.14 CCF44003.1 - 3e-25 88.6 0.0 3.3e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Cnd2 PF05786.9 CCF44006.1 - 6.4e-40 137.3 0.4 7.3e-40 137.1 0.3 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 Gag_p15 PF08723.5 CCF44006.1 - 0.02 14.9 0.0 0.022 14.7 0.0 1.2 1 0 0 1 1 1 0 Gag protein p15 Peptidase_S8 PF00082.17 CCF44007.1 - 4e-08 32.7 0.5 5.8e-08 32.2 0.4 1.2 1 0 0 1 1 1 1 Subtilase family NmrA PF05368.8 CCF44008.1 - 4e-35 121.1 0.0 9.8e-35 119.8 0.0 1.5 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF44008.1 - 7.2e-11 42.4 0.0 1e-10 41.9 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding TrkA_N PF02254.13 CCF44008.1 - 2.5e-06 27.4 0.1 4.2e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 TrkA-N domain 3Beta_HSD PF01073.14 CCF44008.1 - 9.9e-06 24.4 0.0 1.3e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 CCF44008.1 - 0.019 14.4 0.0 0.024 14.0 0.0 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family KR PF08659.5 CCF44008.1 - 0.033 13.8 0.0 0.05 13.2 0.0 1.2 1 0 0 1 1 1 0 KR domain SET PF00856.23 CCF44010.1 - 0.00013 22.2 0.0 0.0014 18.9 0.0 2.2 1 1 0 1 1 1 1 SET domain Peptidase_M2 PF01401.13 CCF44010.1 - 0.057 11.6 0.0 0.085 11.0 0.0 1.1 1 0 0 1 1 1 0 Angiotensin-converting enzyme COesterase PF00135.23 CCF44011.1 - 7.1e-97 325.3 0.0 9.1e-97 324.9 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF44011.1 - 8.5e-08 32.0 0.1 4.8e-07 29.5 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold NTP_transf_3 PF12804.2 CCF44011.1 - 0.059 13.4 0.1 0.1 12.6 0.1 1.4 1 0 0 1 1 1 0 MobA-like NTP transferase domain Abhydrolase_5 PF12695.2 CCF44011.1 - 0.069 12.9 0.1 0.14 11.8 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF44011.1 - 0.12 11.5 0.1 0.2 10.8 0.1 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Ras PF00071.17 CCF44012.1 - 8.9e-32 109.7 0.1 1.2e-31 109.3 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF44012.1 - 3.7e-21 75.8 0.1 2.1e-20 73.3 0.0 1.9 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 CCF44012.1 - 1.1e-06 28.0 0.0 1.3e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CCF44012.1 - 4.4e-05 22.7 0.1 5.8e-05 22.3 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 CCF44012.1 - 0.053 13.4 0.0 0.095 12.6 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase DLIC PF05783.6 CCF44012.1 - 0.055 12.1 0.1 3.8 6.0 0.0 2.1 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) G-alpha PF00503.15 CCF44012.1 - 0.075 11.7 2.2 0.18 10.4 0.0 2.3 1 1 2 3 3 3 0 G-protein alpha subunit Drc1-Sld2 PF11719.3 CCF44013.1 - 0.22 10.6 11.2 0.27 10.3 7.8 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein GCV_H PF01597.14 CCF44014.1 - 4.7e-36 123.1 1.9 5.7e-36 122.8 1.3 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.17 CCF44014.1 - 0.0057 16.2 0.3 0.014 14.9 0.2 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme RnfC_N PF13375.1 CCF44014.1 - 0.062 13.0 0.1 0.09 12.5 0.1 1.4 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Porphobil_deam PF01379.15 CCF44015.1 - 5.7e-78 260.7 0.0 7.6e-78 260.3 0.0 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.10 CCF44015.1 - 1.8e-17 63.1 0.1 3.3e-17 62.3 0.1 1.5 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain AAA PF00004.24 CCF44016.1 - 1.4e-07 31.7 0.0 5.6e-07 29.8 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) HDV_ag PF01517.13 CCF44016.1 - 0.0011 18.6 5.5 0.0033 17.1 3.8 1.7 1 1 0 1 1 1 1 Hepatitis delta virus delta antigen Guanylate_cyc_2 PF09778.4 CCF44016.1 - 0.083 12.0 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 Guanylylate cyclase PLRV_ORF5 PF01690.12 CCF44016.1 - 0.47 9.5 6.7 0.68 9.0 4.6 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein TPD PF14811.1 CCF44016.1 - 2.5 7.6 6.9 0.62 9.5 1.5 2.4 3 0 0 3 3 3 0 Protein of unknown function TPD sequence-motif DUF4558 PF15104.1 CCF44016.1 - 3.7 7.5 11.1 5.1 7.0 5.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4558) Ank_5 PF13857.1 CCF44017.1 - 2.7e-07 30.5 0.1 6.6e-07 29.3 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 CCF44017.1 - 0.02 14.6 0.5 0.056 13.2 0.2 1.9 2 0 0 2 2 2 0 Ankyrin repeat Ank_2 PF12796.2 CCF44017.1 - 0.025 14.9 0.0 0.06 13.7 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF44017.1 - 0.068 13.7 0.0 0.17 12.4 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF44017.1 - 0.12 12.6 0.0 0.55 10.6 0.0 2.1 1 0 0 1 1 1 0 Ankyrin repeat Na_H_Exchanger PF00999.16 CCF44020.1 - 3.5e-66 223.2 25.0 4.3e-66 222.9 17.3 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Nha1_C PF08619.5 CCF44020.1 - 2.6e-08 33.5 2.0 3.3e-08 33.2 1.4 1.1 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Band_7 PF01145.20 CCF44024.1 - 3.1e-26 92.3 2.4 4.6e-26 91.8 1.7 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.1 CCF44024.1 - 0.061 12.8 0.2 0.092 12.2 0.1 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family 2OG-FeII_Oxy_3 PF13640.1 CCF44025.1 - 0.016 15.6 0.3 0.032 14.7 0.2 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Peptidase_M24 PF00557.19 CCF44026.1 - 7.2e-39 133.5 0.0 1e-38 132.9 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.13 CCF44026.1 - 6.3e-05 23.4 0.1 0.0033 17.9 0.0 2.5 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Sugar_tr PF00083.19 CCF44027.1 - 6.2e-36 123.9 28.6 9e-35 120.1 19.8 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF44027.1 - 2.1e-26 92.5 39.9 1.3e-14 53.6 7.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CCF44027.1 - 3.8e-10 38.7 22.4 9.2e-07 27.5 4.0 2.2 1 1 1 2 2 2 2 MFS/sugar transport protein OPT PF03169.10 CCF44028.1 - 3.4e-121 405.6 40.6 3.9e-121 405.4 28.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF2207 PF09972.4 CCF44028.1 - 0.017 13.7 0.1 0.055 12.0 0.1 1.9 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Arylesterase PF01731.15 CCF44029.1 - 0.00092 19.1 0.0 0.0021 18.0 0.0 1.6 1 0 0 1 1 1 1 Arylesterase Tim17 PF02466.14 CCF44030.1 - 1.6e-28 99.2 0.6 2.6e-28 98.6 0.4 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Oxidored_FMN PF00724.15 CCF44031.1 - 8e-81 271.6 0.0 1.1e-80 271.1 0.0 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Ribosomal_S8e PF01201.17 CCF44032.1 - 8.5e-35 119.7 10.2 5.6e-34 117.1 7.1 2.1 1 1 0 1 1 1 1 Ribosomal protein S8e DUF2390 PF09523.5 CCF44032.1 - 1.9 8.6 6.3 3.5 7.8 4.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2390) Bud13 PF09736.4 CCF44032.1 - 2 8.6 13.3 0.92 9.7 7.7 1.5 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex Ribosomal_L21p PF00829.16 CCF44033.1 - 0.0021 18.1 0.0 0.0031 17.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Pkinase PF00069.20 CCF44034.1 - 3.2e-44 151.0 0.0 4.9e-44 150.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF44034.1 - 3.2e-19 69.0 0.0 4.9e-19 68.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF44034.1 - 0.00079 18.4 0.0 0.0027 16.7 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 CCF44034.1 - 0.0037 17.0 0.0 1.2 8.7 0.0 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.17 CCF44034.1 - 0.11 11.8 0.1 0.26 10.6 0.0 1.7 1 1 0 1 1 1 0 RIO1 family Ribosomal_60s PF00428.14 CCF44035.1 - 2.7e-28 98.2 6.6 3e-28 98.0 4.5 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein SPT2 PF08243.6 CCF44036.1 - 2.8e-07 30.8 25.3 2.8e-07 30.8 17.6 3.4 3 1 0 3 3 3 1 SPT2 chromatin protein DUF2457 PF10446.4 CCF44037.1 - 0.00018 20.4 9.3 0.00018 20.4 6.5 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2457) BSP_II PF05432.6 CCF44037.1 - 0.0073 15.6 5.6 0.013 14.8 3.9 1.3 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) eIF-3c_N PF05470.7 CCF44037.1 - 0.036 12.1 1.2 0.038 12.0 0.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Nop14 PF04147.7 CCF44037.1 - 0.12 10.2 10.1 0.17 9.8 7.0 1.1 1 0 0 1 1 1 0 Nop14-like family Vfa1 PF08432.5 CCF44037.1 - 0.18 11.8 8.9 0.35 10.8 6.2 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.9 CCF44037.1 - 0.23 9.4 6.3 0.31 9.0 4.4 1.1 1 0 0 1 1 1 0 CDC45-like protein TRAP_alpha PF03896.11 CCF44037.1 - 0.25 10.3 4.3 0.48 9.3 3.0 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RNA_pol_Rpc4 PF05132.9 CCF44037.1 - 0.43 10.5 2.7 0.88 9.5 1.9 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Peptidase_S64 PF08192.6 CCF44037.1 - 2 6.6 5.7 2.6 6.2 3.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 Nucleoplasmin PF03066.10 CCF44037.1 - 2.3 7.7 14.1 1.1 8.7 7.3 2.0 2 0 0 2 2 2 0 Nucleoplasmin FAM176 PF14851.1 CCF44037.1 - 2.3 7.8 8.6 0.23 11.1 2.7 1.7 2 0 0 2 2 2 0 FAM176 family CobT PF06213.7 CCF44037.1 - 5.8 5.9 12.5 10 5.1 8.7 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pkinase PF00069.20 CCF44038.1 - 6e-62 209.1 0.0 7.6e-62 208.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF44038.1 - 2.6e-31 108.6 0.0 3.9e-31 108.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF44038.1 - 0.0048 15.9 0.0 0.0076 15.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CCF44038.1 - 0.058 13.1 0.0 0.25 11.0 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Gti1_Pac2 PF09729.4 CCF44039.1 - 5.1e-49 166.3 4.0 4.4e-47 160.0 1.4 2.7 2 1 0 2 2 2 1 Gti1/Pac2 family Mus7 PF09462.5 CCF44040.1 - 2.4e-21 76.2 0.5 3.1e-21 75.8 0.3 1.2 1 0 0 1 1 1 1 Mus7/MMS22 family ADH_zinc_N PF00107.21 CCF44041.1 - 9.5e-17 60.7 0.1 2e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF44041.1 - 9.9e-11 42.6 0.0 4.1e-10 40.6 0.0 2.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AAA PF00004.24 CCF44042.1 - 6e-39 133.2 0.0 1.1e-38 132.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CCF44042.1 - 1.5e-06 28.4 0.2 6.8e-05 23.0 0.1 2.8 2 1 0 2 2 1 1 AAA domain RuvB_N PF05496.7 CCF44042.1 - 3.5e-05 22.9 0.0 6.3e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.8 CCF44042.1 - 0.00036 19.3 0.0 0.00085 18.1 0.0 1.5 1 0 0 1 1 1 1 TIP49 C-terminus AAA_16 PF13191.1 CCF44042.1 - 0.00049 20.1 0.3 0.0052 16.7 0.1 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_11 PF13086.1 CCF44042.1 - 0.00066 19.3 0.0 0.0017 17.9 0.0 1.6 2 0 0 2 2 1 1 AAA domain DUF815 PF05673.8 CCF44042.1 - 0.00081 18.3 0.0 0.0014 17.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.12 CCF44042.1 - 0.00082 18.8 0.0 0.0016 17.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.1 CCF44042.1 - 0.001 18.8 0.1 0.016 14.9 0.0 2.6 2 0 0 2 2 2 1 Part of AAA domain AAA_2 PF07724.9 CCF44042.1 - 0.001 19.0 0.0 0.0025 17.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.16 CCF44042.1 - 0.0013 17.9 0.2 0.0053 15.9 0.1 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 CCF44042.1 - 0.0017 18.1 0.1 0.0066 16.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 CCF44042.1 - 0.0047 16.8 0.0 0.082 12.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 CCF44042.1 - 0.0057 16.5 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 CCF44042.1 - 0.0085 16.0 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 CCF44042.1 - 0.0087 15.4 0.2 0.13 11.6 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.1 CCF44042.1 - 0.011 16.5 0.1 0.05 14.4 0.0 2.2 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.1 CCF44042.1 - 0.032 13.7 0.0 0.069 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 CCF44042.1 - 0.041 13.1 0.0 0.18 11.0 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein NACHT PF05729.7 CCF44042.1 - 0.076 12.6 0.0 0.23 11.0 0.0 1.8 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.1 CCF44042.1 - 0.085 13.1 0.0 0.26 11.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 CCF44042.1 - 0.091 11.8 0.0 0.22 10.6 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin Sigma54_activat PF00158.21 CCF44042.1 - 0.14 11.6 0.0 0.33 10.4 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain Arch_ATPase PF01637.13 CCF44042.1 - 0.17 11.5 0.0 0.38 10.4 0.0 1.6 1 0 0 1 1 1 0 Archaeal ATPase Guanylate_kin PF00625.16 CCF44042.1 - 0.19 11.1 0.0 0.44 9.9 0.0 1.6 1 1 0 1 1 1 0 Guanylate kinase DUF2075 PF09848.4 CCF44042.1 - 0.23 10.3 1.2 0.73 8.7 0.0 2.3 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) KaiC PF06745.8 CCF44042.1 - 0.25 10.4 2.5 2.1 7.3 0.0 3.0 3 1 1 4 4 4 0 KaiC PAN_1 PF00024.21 CCF44043.1 - 0.00012 21.7 0.0 0.00017 21.2 0.0 1.2 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.1 CCF44043.1 - 0.00074 19.1 1.2 0.0012 18.5 0.8 1.3 1 0 0 1 1 1 1 PAN domain Oxysterol_BP PF01237.13 CCF44044.1 - 8e-30 103.5 0.0 9e-30 103.3 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein HA2 PF04408.18 CCF44045.1 - 1.3e-19 70.1 0.0 2.5e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 CCF44045.1 - 1.7e-13 50.2 0.0 4.1e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.11 CCF44045.1 - 1.3e-12 47.5 0.0 2.7e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold YL1 PF05764.8 CCF44045.1 - 7.4 6.1 6.0 12 5.4 4.2 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Cytochrom_B561 PF03188.11 CCF44046.1 - 0.011 15.5 3.0 0.011 15.5 2.1 1.9 1 1 0 2 2 2 0 Eukaryotic cytochrome b561 SdpI PF13630.1 CCF44046.1 - 0.017 14.8 4.7 0.017 14.8 3.3 2.0 2 0 0 2 2 2 0 SdpI/YhfL protein family DUF2306 PF10067.4 CCF44046.1 - 0.017 15.2 2.6 0.017 15.2 1.8 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2306) DUF2339 PF10101.4 CCF44046.1 - 0.047 11.9 2.3 0.058 11.6 1.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) Ni_hydr_CYTB PF01292.15 CCF44046.1 - 0.17 11.2 6.4 2.4 7.4 1.1 2.1 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 Pox_P21 PF05313.7 CCF44046.1 - 0.47 9.6 2.3 0.26 10.5 0.1 1.6 2 0 0 2 2 2 0 Poxvirus P21 membrane protein DUF2636 PF11120.3 CCF44046.1 - 0.5 9.9 1.9 0.44 10.0 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2636) DUF4282 PF14110.1 CCF44046.1 - 0.51 10.5 4.7 3.7 7.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) DUF2207 PF09972.4 CCF44046.1 - 4.3 5.8 5.2 1.9 6.9 1.9 1.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) FA_desaturase_2 PF03405.9 CCF44047.1 - 0.048 12.4 0.0 0.055 12.2 0.0 1.1 1 0 0 1 1 1 0 Fatty acid desaturase DUF3647 PF12363.3 CCF44048.1 - 0.085 12.9 0.0 0.58 10.2 0.0 1.9 2 0 0 2 2 2 0 Phage protein PAF-AH_p_II PF03403.8 CCF44049.1 - 1.7e-41 141.8 0.0 1.3e-36 125.7 0.0 2.1 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_5 PF12695.2 CCF44049.1 - 3.7e-10 39.7 0.0 8.3e-10 38.5 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF44049.1 - 0.00038 20.4 0.0 0.00074 19.4 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 CCF44049.1 - 0.0039 16.1 0.0 0.0074 15.2 0.0 1.4 1 0 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.3 CCF44049.1 - 0.006 16.4 0.0 0.015 15.1 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase Chlorophyllase PF07224.6 CCF44049.1 - 0.019 13.7 0.0 0.041 12.6 0.0 1.5 1 0 0 1 1 1 0 Chlorophyllase DLH PF01738.13 CCF44049.1 - 0.026 13.8 0.0 0.044 13.0 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family Peptidase_M43 PF05572.8 CCF44051.1 - 3.4e-10 39.7 0.0 7.2e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_3 PF13582.1 CCF44051.1 - 9.6e-06 26.1 0.1 1.5e-05 25.5 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 CCF44051.1 - 0.00017 21.5 0.0 0.00028 20.8 0.0 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.1 CCF44051.1 - 0.0019 18.2 2.9 0.003 17.6 2.0 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.4 CCF44051.1 - 0.0022 16.9 2.3 0.0032 16.4 1.6 1.2 1 0 0 1 1 1 1 Peptidase M66 Reprolysin_4 PF13583.1 CCF44051.1 - 0.004 16.6 0.0 0.0052 16.3 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.19 CCF44051.1 - 0.0075 16.0 0.1 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Matrixin NAD_binding_1 PF00175.16 CCF44052.1 - 9.8e-23 80.8 0.0 2.3e-22 79.6 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 CCF44052.1 - 2.2e-17 63.0 0.0 1.9e-07 31.1 0.0 2.3 2 0 0 2 2 2 2 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 CCF44052.1 - 0.004 17.0 0.0 3 7.7 0.0 2.5 2 0 0 2 2 2 2 Ferric reductase NAD binding domain STE3 PF02076.10 CCF44053.1 - 9.5e-29 100.3 6.1 1.1e-28 100.1 4.2 1.0 1 0 0 1 1 1 1 Pheromone A receptor ketoacyl-synt PF00109.21 CCF44055.1 - 3e-74 249.7 0.0 1.5e-73 247.4 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 CCF44055.1 - 2.3e-24 85.4 0.1 3.2e-23 81.8 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 CCF44055.1 - 1.8e-06 27.1 0.0 2.9e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 CCF44055.1 - 0.033 13.8 0.5 0.068 12.8 0.0 1.7 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III gag_pre-integrs PF13976.1 CCF44056.1 - 0.00014 21.4 1.0 0.00047 19.7 0.3 2.1 2 0 0 2 2 2 1 GAG-pre-integrase domain Cas_Csa5 PF09702.5 CCF44058.1 - 0.15 12.1 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csa5) DSPc PF00782.15 CCF44059.1 - 7.3e-27 93.5 0.0 6.4e-21 74.3 0.0 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 CCF44059.1 - 0.0001 21.7 0.0 0.00094 18.5 0.0 2.1 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 CCF44059.1 - 0.046 13.7 0.3 0.33 10.9 0.1 2.3 3 0 0 3 3 3 0 Inositol hexakisphosphate CDKN3 PF05706.7 CCF44059.1 - 0.17 11.2 0.0 23 4.4 0.0 2.3 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Catalase PF00199.14 CCF44062.1 - 6.2e-173 574.8 0.8 7.1e-173 574.6 0.6 1.0 1 0 0 1 1 1 1 Catalase SHMT PF00464.14 CCF44063.1 - 4.6e-208 690.4 0.0 5.3e-208 690.2 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_5 PF00266.14 CCF44063.1 - 0.0022 16.8 0.0 0.0032 16.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 CCF44063.1 - 0.095 11.8 0.0 0.16 11.0 0.0 1.5 1 1 0 1 1 1 0 Beta-eliminating lyase Hce2 PF14856.1 CCF44064.1 - 1e-17 63.8 0.1 1.4e-17 63.3 0.1 1.2 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor DUF676 PF05057.9 CCF44065.1 - 8.5e-08 31.7 0.1 1.5e-07 30.9 0.0 1.5 1 1 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.8 CCF44065.1 - 3.2e-05 23.6 0.0 5.7e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.2 CCF44065.1 - 0.00018 21.2 0.0 0.00039 20.2 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF44065.1 - 0.0015 18.5 0.0 0.0031 17.4 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF829 PF05705.9 CCF44065.1 - 0.025 14.2 0.0 0.03 14.0 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) LCAT PF02450.10 CCF44065.1 - 0.085 11.8 0.0 0.14 11.0 0.0 1.3 1 1 0 1 1 1 0 Lecithin:cholesterol acyltransferase Ser_hydrolase PF06821.8 CCF44065.1 - 0.11 12.0 0.1 0.69 9.5 0.0 2.1 2 1 0 2 2 2 0 Serine hydrolase AAA_16 PF13191.1 CCF44066.1 - 4.4e-09 36.5 0.1 6.7e-08 32.7 0.0 2.8 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.17 CCF44066.1 - 8.8e-05 21.4 0.0 0.00012 21.0 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain Zeta_toxin PF06414.7 CCF44066.1 - 0.0027 16.8 0.1 0.041 12.9 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin Arch_ATPase PF01637.13 CCF44066.1 - 0.015 15.0 0.0 0.03 14.0 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase AAA_33 PF13671.1 CCF44066.1 - 0.016 15.0 0.0 0.057 13.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain KaiC PF06745.8 CCF44066.1 - 0.018 14.2 0.0 0.032 13.3 0.0 1.3 1 0 0 1 1 1 0 KaiC DUF2075 PF09848.4 CCF44066.1 - 0.019 13.9 0.0 0.032 13.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_17 PF13207.1 CCF44066.1 - 0.022 15.6 0.1 0.087 13.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 CCF44066.1 - 0.022 14.8 0.0 0.076 13.1 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 CCF44066.1 - 0.023 14.4 0.0 0.067 12.9 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain RuvB_N PF05496.7 CCF44066.1 - 0.028 13.4 0.0 0.059 12.4 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus Viral_helicase1 PF01443.13 CCF44066.1 - 0.033 13.6 0.5 0.7 9.3 0.0 2.8 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase NACHT PF05729.7 CCF44066.1 - 0.04 13.5 0.0 0.092 12.3 0.0 1.7 1 1 0 1 1 1 0 NACHT domain AAA_14 PF13173.1 CCF44066.1 - 0.081 12.8 0.0 0.31 10.9 0.0 2.1 1 1 1 2 2 2 0 AAA domain P3A PF08727.6 CCF44067.1 - 0.015 14.5 1.1 0.14 11.5 0.0 2.8 3 0 0 3 3 3 0 Poliovirus 3A protein like DDE_1 PF03184.14 CCF44069.1 - 2.2e-51 174.0 0.0 2.9e-51 173.6 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.11 CCF44069.1 - 1.8e-10 40.1 0.2 4e-10 39.0 0.2 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF44069.1 - 2.5e-05 24.0 0.0 6.3e-05 22.7 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_AsnC-type PF13404.1 CCF44069.1 - 0.012 15.1 0.1 0.03 13.8 0.1 1.6 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_23 PF13384.1 CCF44069.1 - 0.029 14.0 0.1 0.076 12.6 0.1 1.7 1 0 0 1 1 1 0 Homeodomain-like domain Xan_ur_permease PF00860.15 CCF44070.1 - 9.3e-25 86.9 24.7 1.7e-23 82.7 16.0 3.0 2 1 0 2 2 2 1 Permease family ECH PF00378.15 CCF44071.1 - 6.9e-11 41.7 0.0 9.2e-11 41.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family 4HBT_2 PF13279.1 CCF44072.1 - 5.5e-07 30.0 0.0 1e-06 29.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase-like superfamily Fungal_trans PF04082.13 CCF44073.1 - 3.9e-17 61.9 0.0 5.8e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ycf9 PF01737.12 CCF44073.1 - 0.039 13.3 0.1 0.099 12.1 0.1 1.7 1 0 0 1 1 1 0 YCF9 bZIP_1 PF00170.16 CCF44074.1 - 5.8e-07 29.3 9.6 3e-06 27.0 6.7 2.1 1 1 0 1 1 1 1 bZIP transcription factor Leu_zip PF15294.1 CCF44074.1 - 0.00061 18.9 0.5 0.00061 18.9 0.3 1.7 2 0 0 2 2 2 1 Leucine zipper Complex1_LYR_2 PF13233.1 CCF44074.1 - 0.07 13.6 2.4 0.091 13.2 0.2 1.9 2 0 0 2 2 2 0 Complex1_LYR-like Adeno_PIX PF03955.9 CCF44074.1 - 0.46 11.0 4.8 0.39 11.2 1.0 2.1 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) bZIP_2 PF07716.10 CCF44074.1 - 0.47 10.3 11.6 3.1 7.6 4.4 2.6 1 1 1 2 2 2 0 Basic region leucine zipper dsrm PF00035.20 CCF44074.1 - 1 9.9 3.7 2.9 8.5 2.6 2.0 1 1 0 1 1 1 0 Double-stranded RNA binding motif DUF501 PF04417.7 CCF44074.1 - 1.4 8.7 6.9 0.098 12.5 0.7 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF501) HTH_psq PF05225.11 CCF44077.1 - 2.4e-14 52.5 0.2 4.4e-14 51.7 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF44077.1 - 1.9e-12 46.8 0.6 6.3e-12 45.1 0.0 2.1 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.1 CCF44077.1 - 7.7e-05 22.2 0.1 0.00027 20.4 0.0 2.0 1 1 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 CCF44077.1 - 0.00032 20.6 0.1 0.00093 19.1 0.1 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_7 PF02796.10 CCF44077.1 - 0.0013 18.5 0.1 0.0025 17.6 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.1 CCF44077.1 - 0.0025 17.3 0.1 0.0057 16.2 0.1 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_1 PF00126.22 CCF44077.1 - 0.026 14.2 0.3 0.056 13.1 0.2 1.6 1 1 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family DDE_1 PF03184.14 CCF44077.1 - 0.028 13.5 0.0 0.077 12.1 0.0 1.8 2 0 0 2 2 2 0 DDE superfamily endonuclease SpoIIID PF12116.3 CCF44077.1 - 0.059 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Stage III sporulation protein D CENP-B_N PF04218.8 CCF44077.1 - 0.07 12.5 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_8 PF02954.14 CCF44077.1 - 0.11 12.0 0.7 0.63 9.6 0.0 2.3 1 1 1 2 2 2 0 Bacterial regulatory protein, Fis family HMG_box PF00505.14 CCF44078.1 - 2.7e-09 37.1 0.3 5.6e-09 36.1 0.2 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 CCF44078.1 - 9.3e-05 22.7 0.1 0.00029 21.1 0.1 2.0 1 0 0 1 1 1 1 HMG-box domain Het-C PF07217.6 CCF44081.1 - 2.4e-261 868.2 0.0 3.4e-261 867.7 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C DDE_1 PF03184.14 CCF44083.1 - 2.9e-27 95.2 0.0 4.7e-27 94.5 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.11 CCF44083.1 - 1.6e-12 46.7 0.0 2.8e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF44083.1 - 3.7e-09 36.2 0.0 9.4e-09 34.9 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.1 CCF44083.1 - 0.0019 17.7 0.2 0.0089 15.6 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 CCF44083.1 - 0.11 12.5 0.1 0.28 11.2 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain ATP-grasp_4 PF13535.1 CCF44084.1 - 4.7e-08 32.9 0.0 5e-07 29.6 0.0 2.4 2 1 0 2 2 2 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 CCF44084.1 - 3.6e-06 25.9 0.0 2.8e-05 23.0 0.0 2.1 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon AAA PF00004.24 CCF44085.1 - 1.1e-14 54.7 0.0 7.5e-14 52.0 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) BAH PF01426.13 CCF44085.1 - 7.9e-11 41.7 0.0 1.7e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 BAH domain AAA_16 PF13191.1 CCF44085.1 - 7.2e-10 39.1 0.0 1e-08 35.4 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CCF44085.1 - 6.3e-09 36.0 0.0 3.3e-07 30.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 CCF44085.1 - 0.001 18.8 0.0 0.012 15.3 0.0 2.5 2 1 0 2 2 2 1 Archaeal ATPase AAA_17 PF13207.1 CCF44085.1 - 0.0016 19.2 0.0 0.038 14.7 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.1 CCF44085.1 - 0.0017 18.0 0.1 0.0049 16.5 0.1 1.8 1 0 0 1 1 1 1 Part of AAA domain DUF2075 PF09848.4 CCF44085.1 - 0.0021 17.0 0.0 0.003 16.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.1 CCF44085.1 - 0.013 15.0 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CCF44085.1 - 0.016 15.5 0.0 0.035 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zot PF05707.7 CCF44085.1 - 0.026 13.9 0.0 0.044 13.2 0.0 1.3 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) NACHT PF05729.7 CCF44085.1 - 0.033 13.8 0.0 0.068 12.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_32 PF13654.1 CCF44085.1 - 0.077 11.6 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain Baculo_11_kDa PF06143.6 CCF44085.1 - 0.14 11.5 0.0 0.31 10.4 0.0 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family MFS_1 PF07690.11 CCF44086.1 - 9e-32 110.1 18.4 9e-32 110.1 12.7 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Cation_ATPase_C PF00689.16 CCF44086.1 - 2.4 7.6 0.0 2.4 7.6 0.0 4.2 3 2 1 4 4 4 0 Cation transporting ATPase, C-terminus Pkinase PF00069.20 CCF44089.1 - 9.5e-61 205.2 0.0 1.3e-60 204.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF44089.1 - 2.6e-28 98.8 0.0 4.8e-28 97.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF44089.1 - 0.00095 18.2 0.0 0.0016 17.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CCF44089.1 - 0.022 14.5 0.1 0.11 12.2 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 CCF44089.1 - 0.049 12.7 0.0 0.084 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DivIC PF04977.10 CCF44089.1 - 9.8 5.7 7.2 16 5.0 5.0 1.4 1 0 0 1 1 1 0 Septum formation initiator Methyltransf_28 PF02636.12 CCF44090.1 - 1.1e-78 264.1 0.0 1.5e-78 263.7 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Lung_7-TM_R PF06814.8 CCF44091.1 - 1.9e-71 240.4 16.1 2.3e-71 240.1 11.2 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor DUF4492 PF14899.1 CCF44091.1 - 0.032 13.7 1.2 0.12 11.8 0.8 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4492) PrgI PF12666.2 CCF44091.1 - 0.13 12.4 22.5 0.35 11.0 2.6 3.6 1 1 1 3 3 3 0 PrgI family protein Pro_isomerase PF00160.16 CCF44092.1 - 1.8e-46 158.1 0.0 3.3e-46 157.3 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD U-box PF04564.10 CCF44092.1 - 0.0005 19.9 0.0 0.0018 18.2 0.0 1.9 1 0 0 1 1 1 1 U-box domain Fungal_trans_2 PF11951.3 CCF44093.1 - 9.5e-10 37.6 0.1 2.7e-07 29.5 0.0 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Flu_M1_C PF08289.6 CCF44093.1 - 0.0076 16.2 0.0 0.022 14.7 0.0 1.7 1 0 0 1 1 1 1 Influenza Matrix protein (M1) C-terminal domain FAD_binding_3 PF01494.14 CCF44095.1 - 2.4e-09 36.7 0.0 2.4e-09 36.7 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 CCF44095.1 - 0.00049 20.0 0.1 0.00071 19.5 0.1 1.6 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 CCF44095.1 - 0.0017 18.7 0.2 0.0024 18.2 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF44095.1 - 0.012 14.5 0.0 0.012 14.5 0.0 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase Amino_oxidase PF01593.19 CCF44095.1 - 0.04 12.9 0.0 0.048 12.7 0.0 1.1 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.9 CCF44095.1 - 0.056 13.3 0.0 0.056 13.3 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Na_H_antiport_2 PF13726.1 CCF44095.1 - 0.15 11.9 0.6 3.8 7.4 0.1 2.1 1 1 1 2 2 2 0 Na+-H+ antiporter family Nucleos_tra2_C PF07662.8 CCF44097.1 - 3.2e-66 222.8 5.6 3.2e-66 222.8 3.9 2.7 2 1 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.15 CCF44097.1 - 2.7e-23 82.0 1.3 2.7e-23 82.0 0.9 2.8 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.9 CCF44097.1 - 0.0043 16.9 8.6 0.0043 16.9 6.0 3.6 4 0 0 4 4 4 1 Nucleoside recognition adh_short PF00106.20 CCF44099.1 - 5.1e-16 59.0 0.3 2.3e-15 56.8 0.1 1.9 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 CCF44099.1 - 3.1e-07 30.2 0.1 5.6e-07 29.4 0.1 1.4 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF44099.1 - 0.00066 19.5 0.0 0.0011 18.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Peptidase_M14 PF00246.19 CCF44101.1 - 3.3e-61 207.3 0.1 4.1e-61 207.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.11 CCF44101.1 - 0.0015 18.1 0.3 0.0026 17.3 0.2 1.4 1 0 0 1 1 1 1 Carboxypeptidase activation peptide DUF3089 PF11288.3 CCF44102.1 - 0.082 12.0 0.0 0.21 10.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Peptidase_S8 PF00082.17 CCF44103.1 - 8.4e-43 146.5 0.0 2.5e-42 144.9 0.0 1.8 1 1 0 1 1 1 1 Subtilase family DUF1034 PF06280.7 CCF44103.1 - 5.5e-18 65.4 0.1 1.9e-17 63.6 0.0 2.0 2 0 0 2 2 2 1 Fn3-like domain (DUF1034) Fungal_trans_2 PF11951.3 CCF44104.1 - 2.4e-48 164.6 0.2 3.1e-48 164.2 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF44104.1 - 8.4e-07 28.7 4.7 1.7e-06 27.8 3.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4281 PF14108.1 CCF44104.1 - 4.4e-05 23.5 0.2 0.00016 21.7 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4281) PBP PF01161.15 CCF44105.1 - 2.3e-15 56.7 0.0 4.3e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Secretin_N_2 PF07655.8 CCF44105.1 - 0.084 13.2 8.4 0.16 12.3 5.8 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Pkinase PF00069.20 CCF44106.1 - 1.8e-10 40.4 0.0 2.8e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 CCF44106.1 - 1.8e-05 23.8 0.0 2.7e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CCF44106.1 - 0.0002 21.1 0.3 0.00074 19.3 0.2 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 CCF44106.1 - 0.00035 19.7 0.0 0.00048 19.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.6 CCF44106.1 - 0.014 14.6 0.0 0.025 13.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) DNA_pol_alpha_N PF12254.3 CCF44107.1 - 2e-22 78.7 10.8 2e-22 78.7 7.5 2.5 3 0 0 3 3 3 1 DNA polymerase alpha subunit p180 N terminal WT1 PF02165.10 CCF44107.1 - 0.016 14.3 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 Wilm's tumour protein AT_hook PF02178.14 CCF44107.1 - 1.4 8.8 9.2 0.25 11.1 1.9 2.8 2 0 0 2 2 2 0 AT hook motif ABC_membrane PF00664.18 CCF44108.1 - 3.1e-35 121.9 8.5 3.8e-35 121.6 5.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 CCF44108.1 - 1.7e-34 119.0 0.0 3.1e-34 118.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 CCF44108.1 - 2.8e-07 29.9 0.0 9.1e-05 21.7 0.0 2.6 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_30 PF13604.1 CCF44108.1 - 6.7e-05 22.5 1.6 0.0094 15.5 0.3 3.2 2 1 0 2 2 2 1 AAA domain ABC_ATPase PF09818.4 CCF44108.1 - 0.00015 20.4 0.0 0.00034 19.3 0.0 1.5 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_21 PF13304.1 CCF44108.1 - 0.00019 21.5 0.0 0.2 11.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 CCF44108.1 - 0.00051 20.0 0.1 0.0011 18.9 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.1 CCF44108.1 - 0.00081 18.8 0.0 0.0019 17.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.1 CCF44108.1 - 0.0032 17.5 0.2 0.053 13.6 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 CCF44108.1 - 0.0089 15.4 0.0 0.13 11.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 CCF44108.1 - 0.01 15.0 0.0 0.019 14.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 SbcCD_C PF13558.1 CCF44108.1 - 0.044 13.7 0.3 0.26 11.2 0.2 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_17 PF13207.1 CCF44108.1 - 0.072 13.9 0.0 0.19 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 CCF44108.1 - 0.12 12.5 0.0 1.3 9.1 0.0 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PRK PF00485.13 CCF44108.1 - 0.16 11.5 0.1 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Rhomboid PF01694.17 CCF44108.1 - 2.9 7.9 10.4 0.14 12.1 2.4 2.3 3 0 0 3 3 3 0 Rhomboid family ABC2_membrane PF01061.19 CCF44109.1 - 5.8e-19 68.0 12.6 5.8e-19 68.0 8.7 1.9 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 CCF44109.1 - 0.00019 20.5 11.3 0.00027 20.0 7.8 1.3 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.2 CCF44109.1 - 0.028 13.3 1.5 0.034 13.0 1.0 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein SCAMP PF04144.8 CCF44109.1 - 1.9 8.3 8.6 11 5.7 4.5 2.6 2 1 0 2 2 2 0 SCAMP family NACHT PF05729.7 CCF44110.1 - 8.1e-12 45.1 0.0 1.4e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 CCF44110.1 - 1.3e-06 28.4 0.2 4.9e-06 26.6 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CCF44110.1 - 1.4e-05 25.2 0.0 3.4e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 CCF44110.1 - 3.3e-05 24.0 0.1 0.001 19.2 0.0 2.2 2 0 0 2 2 2 1 RNA helicase AAA PF00004.24 CCF44110.1 - 0.00049 20.3 0.1 0.0036 17.5 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 CCF44110.1 - 0.00075 19.3 0.1 0.0013 18.6 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 CCF44110.1 - 0.00075 18.9 0.0 0.0013 18.1 0.0 1.3 1 1 0 1 1 1 1 AAA domain XPC-binding PF09280.6 CCF44110.1 - 0.0058 16.0 1.2 0.01 15.2 0.1 1.9 2 0 0 2 2 2 1 XPC-binding domain AAA_17 PF13207.1 CCF44110.1 - 0.0064 17.2 0.1 0.02 15.6 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 CCF44110.1 - 0.0072 16.6 0.0 0.014 15.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.1 CCF44110.1 - 0.026 14.0 0.0 0.037 13.6 0.0 1.3 1 1 0 1 1 1 0 AAA domain Torsin PF06309.6 CCF44110.1 - 0.036 13.9 0.0 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 Torsin AAA_5 PF07728.9 CCF44110.1 - 0.049 13.3 0.0 0.78 9.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 CCF44110.1 - 0.064 13.0 0.2 0.16 11.7 0.0 1.7 2 0 0 2 2 2 0 Part of AAA domain APS_kinase PF01583.15 CCF44110.1 - 0.071 12.7 0.2 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase DUF2075 PF09848.4 CCF44110.1 - 0.074 12.0 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RuvB_N PF05496.7 CCF44110.1 - 0.098 11.6 0.0 0.2 10.6 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus NOG1 PF06858.9 CCF44110.1 - 0.14 12.0 0.1 0.4 10.6 0.0 1.7 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) KAP_NTPase PF07693.9 CCF44110.1 - 0.14 11.1 0.0 1.2 8.0 0.0 2.0 2 0 0 2 2 2 0 KAP family P-loop domain NB-ARC PF00931.17 CCF44110.1 - 0.17 10.7 0.1 0.21 10.4 0.0 1.4 1 1 0 1 1 1 0 NB-ARC domain Helicase_C PF00271.26 CCF44111.1 - 2e-05 24.3 0.0 5.5e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Pkinase PF00069.20 CCF44112.1 - 1.8e-71 240.3 0.0 3.4e-71 239.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF44112.1 - 1.3e-36 125.9 0.0 3.2e-36 124.7 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF44112.1 - 0.00051 19.1 0.4 0.54 9.1 0.0 2.4 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 CCF44112.1 - 0.009 15.7 0.8 0.19 11.3 0.0 2.9 2 2 1 3 3 3 2 Phosphotransferase enzyme family DASH_Spc34 PF08657.5 CCF44114.1 - 4.1e-14 52.8 2.9 4.8e-14 52.6 2.0 1.0 1 0 0 1 1 1 1 DASH complex subunit Spc34 SlyX PF04102.7 CCF44114.1 - 0.024 14.9 4.2 0.077 13.3 0.4 2.2 2 0 0 2 2 2 0 SlyX Cwf_Cwc_15 PF04889.7 CCF44114.1 - 0.26 10.9 8.8 0.31 10.7 6.1 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein BBS2_C PF14782.1 CCF44114.1 - 0.27 9.7 3.4 0.13 10.8 1.0 1.4 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal V_ATPase_I PF01496.14 CCF44114.1 - 0.36 8.6 2.0 0.42 8.4 1.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NOA36 PF06524.7 CCF44114.1 - 0.37 10.0 5.2 0.45 9.7 3.6 1.1 1 0 0 1 1 1 0 NOA36 protein Toxin_44 PF15523.1 CCF44114.1 - 0.43 10.4 3.3 0.17 11.8 0.3 1.8 2 0 0 2 2 2 0 Putative toxin 44 DUF4637 PF15470.1 CCF44114.1 - 0.57 9.7 5.4 0.81 9.2 3.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) TBCA PF02970.11 CCF44114.1 - 3.2 7.8 10.9 4.8e+02 0.9 7.4 2.3 1 1 0 1 1 1 0 Tubulin binding cofactor A Spt5_N PF11942.3 CCF44114.1 - 5.7 7.6 19.3 3.6 8.2 9.6 2.1 1 1 1 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal DSBA PF01323.15 CCF44115.1 - 2.1e-32 112.2 0.0 2.4e-32 112.0 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_3 PF13192.1 CCF44115.1 - 9.2e-06 25.3 0.1 0.00041 20.0 0.0 2.5 2 1 0 3 3 3 1 Thioredoxin domain Thioredoxin_4 PF13462.1 CCF44115.1 - 8e-05 22.6 0.0 0.00021 21.3 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.1 CCF44115.1 - 0.025 14.7 0.0 1.4 9.1 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin-like domain Thioredoxin_5 PF13743.1 CCF44115.1 - 0.06 12.9 0.0 0.58 9.7 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin DUF1525 PF07511.6 CCF44115.1 - 0.069 13.1 0.1 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) DUF2223 PF09985.4 CCF44115.1 - 0.092 12.0 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2223) RNA_pol_3_Rpc31 PF11705.3 CCF44116.1 - 0.011 15.7 12.0 0.021 14.7 8.3 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 NOA36 PF06524.7 CCF44116.1 - 0.24 10.6 10.0 0.35 10.0 7.0 1.2 1 0 0 1 1 1 0 NOA36 protein BUD22 PF09073.5 CCF44116.1 - 0.31 10.0 19.8 0.39 9.7 13.7 1.2 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.9 CCF44116.1 - 2 6.3 11.2 2.5 6.0 7.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Nucleo_P87 PF07267.6 CCF44116.1 - 2.1 6.9 8.0 3.3 6.2 5.5 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Nop14 PF04147.7 CCF44116.1 - 5.6 4.7 21.2 7.8 4.2 14.7 1.2 1 0 0 1 1 1 0 Nop14-like family DUF3446 PF11928.3 CCF44118.1 - 3.7 7.7 6.3 1 9.6 1.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3446) Aminotran_1_2 PF00155.16 CCF44120.1 - 1.1e-58 198.9 0.0 1.3e-58 198.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.2 CCF44120.1 - 0.029 12.9 0.0 0.039 12.5 0.0 1.3 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase DUF3763 PF12592.3 CCF44120.1 - 0.11 12.1 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3763) HpcH_HpaI PF03328.9 CCF44121.1 - 0.012 14.4 0.0 0.014 14.2 0.0 1.2 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family Pkinase PF00069.20 CCF44123.1 - 2.2e-59 200.7 0.0 2.8e-59 200.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF44123.1 - 1.5e-32 112.7 0.0 4.3e-31 107.9 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 CCF44123.1 - 0.01 14.6 0.0 0.014 14.1 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.9 CCF44123.1 - 0.25 10.3 0.6 0.44 9.5 0.4 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family F-box-like PF12937.2 CCF44124.1 - 0.032 13.9 0.3 0.13 11.9 0.0 2.2 2 0 0 2 2 2 0 F-box-like LRR_4 PF12799.2 CCF44124.1 - 0.17 11.5 0.2 5.5 6.7 0.2 2.9 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) Fungal_trans_2 PF11951.3 CCF44125.1 - 1.5e-29 102.7 0.9 3.4e-29 101.6 0.7 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF44125.1 - 8e-09 35.2 5.5 1.3e-08 34.6 3.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FoP_duplication PF13865.1 CCF44126.1 - 6.3 7.3 9.0 11 6.5 6.2 1.6 1 1 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Kinesin PF00225.18 CCF44127.1 - 1.9e-106 355.5 0.0 3.2e-106 354.8 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain FHA PF00498.21 CCF44127.1 - 7.7e-05 22.7 0.0 0.00074 19.5 0.0 2.3 2 0 0 2 2 2 1 FHA domain Ribosomal_S2 PF00318.15 CCF44127.1 - 0.23 10.6 1.0 0.39 9.8 0.1 1.8 2 0 0 2 2 2 0 Ribosomal protein S2 WD40 PF00400.27 CCF44128.1 - 2.8e-05 23.8 3.0 0.0046 16.7 0.7 3.6 4 0 0 4 4 4 2 WD domain, G-beta repeat ATP-synt_E PF05680.7 CCF44129.1 - 1.5e-24 85.7 0.2 1.6e-24 85.6 0.1 1.0 1 0 0 1 1 1 1 ATP synthase E chain CotJB PF12652.2 CCF44129.1 - 0.028 14.4 0.2 0.041 13.9 0.1 1.3 1 0 0 1 1 1 0 CotJB protein Drf_GBD PF06371.8 CCF44129.1 - 0.049 12.9 0.0 0.05 12.9 0.0 1.1 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain ABC_trans_N PF14510.1 CCF44129.1 - 0.065 13.3 0.1 0.086 12.9 0.1 1.3 1 0 0 1 1 1 0 ABC-transporter extracellular N-terminal DUF349 PF03993.7 CCF44129.1 - 0.11 12.6 4.1 0.16 12.1 2.9 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) STT3 PF02516.9 CCF44130.1 - 1.5e-124 416.6 39.5 1.4e-119 400.2 25.6 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit Dpy19 PF10034.4 CCF44130.1 - 0.011 13.9 0.1 0.036 12.2 0.1 1.8 1 1 0 1 1 1 0 Q-cell neuroblast polarisation CoA_trans PF01144.18 CCF44132.1 - 9.5e-68 227.6 0.2 6.4e-58 195.4 0.4 2.1 2 0 0 2 2 2 2 Coenzyme A transferase MFS_1 PF07690.11 CCF44133.1 - 0.039 12.6 0.1 0.044 12.4 0.0 1.0 1 0 0 1 1 1 0 Major Facilitator Superfamily Cdc6_C PF09079.6 CCF44134.1 - 1.2e-05 24.9 0.1 6e-05 22.6 0.0 2.2 2 0 0 2 2 2 1 CDC6, C terminal AAA_22 PF13401.1 CCF44134.1 - 0.00039 20.5 1.6 0.00053 20.1 0.1 2.0 2 1 0 2 2 2 1 AAA domain AAA PF00004.24 CCF44134.1 - 0.00078 19.6 0.0 0.0028 17.8 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Fanconi_A PF03511.9 CCF44134.1 - 0.12 12.2 0.1 0.51 10.1 0.0 2.1 2 0 0 2 2 2 0 Fanconi anaemia group A protein AAA_16 PF13191.1 CCF44134.1 - 0.13 12.1 1.7 0.66 9.9 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain Recombinase PF07508.8 CCF44135.1 - 0.086 13.0 0.0 0.4 10.9 0.0 2.0 2 0 0 2 2 2 0 Recombinase Nucleoplasmin PF03066.10 CCF44135.1 - 0.55 9.7 2.9 0.9 9.0 2.0 1.2 1 0 0 1 1 1 0 Nucleoplasmin Pyr_redox_2 PF07992.9 CCF44136.1 - 5.5e-19 68.8 0.0 3.8e-18 66.0 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF44136.1 - 1.6e-15 57.2 3.9 9.3e-14 51.5 0.2 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF44136.1 - 5.1e-07 29.9 0.6 0.0001 22.4 0.0 2.3 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF44136.1 - 4.9e-05 23.1 0.4 0.22 11.3 0.0 3.1 2 1 1 3 3 3 2 FAD-NAD(P)-binding Amino_oxidase PF01593.19 CCF44136.1 - 0.0081 15.2 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase GIDA PF01134.17 CCF44136.1 - 0.013 14.3 0.1 3.5 6.3 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_binding_7 PF13241.1 CCF44136.1 - 0.03 14.5 0.1 1.1 9.4 0.0 2.3 2 1 0 2 2 2 0 Putative NAD(P)-binding K_oxygenase PF13434.1 CCF44136.1 - 0.033 13.1 0.0 0.071 12.0 0.0 1.5 1 1 1 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 CCF44136.1 - 0.07 13.1 0.1 1.2 9.2 0.0 2.5 2 1 0 2 2 2 0 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.16 CCF44136.1 - 0.091 12.3 0.2 14 5.2 0.0 2.5 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.7 CCF44136.1 - 0.13 11.1 0.1 3.2 6.5 0.0 2.4 3 0 0 3 3 3 0 Lycopene cyclase protein TrkA_N PF02254.13 CCF44136.1 - 0.13 12.2 0.4 9.6 6.2 0.0 2.8 3 0 0 3 3 3 0 TrkA-N domain BMF PF15185.1 CCF44137.1 - 0.03 13.6 0.1 0.039 13.2 0.1 1.2 1 0 0 1 1 1 0 Bcl-2-modifying factor, apoptosis ADK PF00406.17 CCF44138.1 - 1.3e-21 77.0 0.0 1.6e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_18 PF13238.1 CCF44138.1 - 0.0036 17.6 0.0 0.0052 17.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain MFS_1 PF07690.11 CCF44139.1 - 7.2e-06 24.9 16.7 9e-06 24.6 11.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1295 PF06966.7 CCF44139.1 - 0.038 13.2 0.7 0.057 12.6 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) WSC PF01822.14 CCF44141.1 - 3.5e-16 58.8 9.7 3.5e-16 58.8 6.7 3.0 2 1 0 2 2 2 1 WSC domain CFEM PF05730.6 CCF44141.1 - 9.9e-12 44.5 5.0 9.9e-12 44.5 3.5 2.7 2 0 0 2 2 2 2 CFEM domain p450 PF00067.17 CCF44143.1 - 5.2e-09 35.1 0.2 5.8e-09 34.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 AMP-binding PF00501.23 CCF44144.1 - 3.3e-39 134.4 0.6 4.5e-39 134.0 0.4 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PLRV_ORF5 PF01690.12 CCF44144.1 - 0.14 11.2 2.1 0.2 10.7 1.4 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein DEC-1_N PF04625.8 CCF44144.1 - 5.4 5.5 10.6 7.9 5.0 7.3 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region AMP-binding PF00501.23 CCF44145.1 - 5.1e-15 54.7 0.0 7.7e-15 54.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.20 CCF44145.1 - 1e-12 48.0 0.0 2e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.1 CCF44145.1 - 1.2e-05 26.1 0.6 8.7e-05 23.3 0.3 2.3 2 1 0 2 2 2 1 AMP-binding enzyme C-terminal domain p450 PF00067.17 CCF44146.1 - 2.8e-31 108.5 0.0 3.5e-31 108.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 CCF44147.1 - 4.4e-32 111.2 0.0 7.9e-32 110.3 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 DUF3391 PF11871.3 CCF44147.1 - 0.15 12.2 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) DUF2116 PF09889.4 CCF44148.1 - 4.3 7.2 6.4 16 5.3 0.3 2.4 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Arylsulfotran_2 PF14269.1 CCF44150.1 - 1.1e-50 172.5 0.0 1.3e-50 172.2 0.0 1.1 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.6 CCF44150.1 - 1.9e-17 62.9 0.0 3.1e-16 58.9 0.0 2.4 2 1 0 2 2 2 1 Arylsulfotransferase (ASST) Glyco_hydro_2_C PF02836.12 CCF44152.1 - 4.6e-98 327.7 0.0 7.1e-98 327.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.13 CCF44152.1 - 7.2e-53 178.5 0.6 1.2e-52 177.7 0.4 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.16 CCF44152.1 - 2.9e-11 43.7 0.0 2.6e-10 40.6 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 BetaGal_dom4_5 PF13364.1 CCF44152.1 - 0.021 15.0 0.4 0.37 11.0 0.0 2.5 2 0 0 2 2 2 0 Beta-galactosidase jelly roll domain CTDII PF01556.13 CCF44152.1 - 0.11 12.3 0.0 0.32 10.9 0.0 1.7 1 0 0 1 1 1 0 DnaJ C terminal domain Oxidored_FMN PF00724.15 CCF44153.1 - 4.3e-37 127.8 0.0 5e-37 127.6 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Sugar_tr PF00083.19 CCF44155.1 - 7.5e-60 202.7 13.9 8.4e-60 202.6 9.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF44155.1 - 7.3e-10 38.0 28.0 1.6e-05 23.8 10.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_M35 PF02102.10 CCF44156.1 - 1.8e-29 102.4 1.3 2.2e-29 102.2 0.9 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Pro_Al_protease PF02983.9 CCF44156.1 - 2.3 8.2 6.4 0.69 9.9 0.7 2.4 2 0 0 2 2 2 0 Alpha-lytic protease prodomain GFO_IDH_MocA PF01408.17 CCF44157.1 - 4e-18 66.0 0.0 5.9e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Sugar_tr PF00083.19 CCF44158.1 - 9.9e-85 284.7 18.4 1.1e-84 284.5 12.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF44158.1 - 3e-33 114.9 44.7 1.8e-25 89.4 16.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily GFO_IDH_MocA PF01408.17 CCF44159.1 - 6.4e-19 68.6 0.0 1.9e-18 67.0 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold LRRNT_2 PF08263.7 CCF44160.1 - 0.02 14.8 0.1 0.051 13.5 0.1 1.7 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain MtmB PF05369.7 CCF44160.1 - 0.23 9.5 3.8 0.28 9.3 2.6 1.0 1 0 0 1 1 1 0 Monomethylamine methyltransferase MtmB Lamprin PF06403.6 CCF44160.1 - 1.7 8.4 6.6 4.4 7.0 4.6 1.7 1 1 0 1 1 1 0 Lamprin Zn_clus PF00172.13 CCF44161.1 - 6.4e-10 38.7 11.8 9.6e-10 38.2 8.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.21 CCF44162.1 - 0.00063 19.9 4.0 0.00063 19.9 2.8 4.0 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF44162.1 - 0.00076 19.6 3.0 0.00076 19.6 2.1 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger YdjO PF14169.1 CCF44162.1 - 0.053 12.9 0.1 6.1 6.3 0.0 2.7 2 0 0 2 2 2 0 Cold-inducible protein YdjO DUF3129 PF11327.3 CCF44163.1 - 3.4e-53 180.1 11.6 4.2e-53 179.8 8.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3129) PS-DH PF14765.1 CCF44164.1 - 2.5e-56 191.0 0.0 4e-56 190.3 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.16 CCF44164.1 - 7.7e-56 189.7 0.3 2.2e-55 188.2 0.2 1.8 1 1 0 1 1 1 1 Acyl transferase domain Dioxygenase_C PF00775.16 CCF44165.1 - 4.1e-09 35.9 0.0 5.3e-06 25.8 0.0 2.5 2 1 0 2 2 2 2 Dioxygenase PufQ PF05398.6 CCF44166.1 - 0.26 11.3 2.6 5.7 7.0 0.0 3.3 4 0 0 4 4 4 0 PufQ cytochrome subunit SPC12 PF06645.8 CCF44166.1 - 1.1 9.1 0.0 1.1 9.1 0.0 2.7 3 0 0 3 3 3 0 Microsomal signal peptidase 12 kDa subunit (SPC12) S1-P1_nuclease PF02265.11 CCF44167.1 - 9.1e-61 205.6 0.0 1e-60 205.4 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease Na_H_Exchanger PF00999.16 CCF44171.1 - 1.8e-34 118.9 10.0 2.2e-34 118.6 7.0 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF3112 PF11309.3 CCF44171.1 - 0.045 13.5 0.1 9.3 6.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3112) TPP_enzyme_N PF02776.13 CCF44172.1 - 1.3e-32 112.6 0.3 5.8e-30 104.0 0.1 3.6 3 1 0 3 3 3 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 CCF44172.1 - 5.6e-23 81.2 0.1 1.4e-22 79.9 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 CCF44172.1 - 1.6e-22 79.7 0.0 6.7e-22 77.7 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TYW3 PF02676.9 CCF44172.1 - 0.074 12.1 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase TYW3 FtsX PF02687.16 CCF44173.1 - 0.041 13.6 1.9 3 7.6 0.4 2.1 2 0 0 2 2 2 0 FtsX-like permease family DUF1049 PF06305.6 CCF44173.1 - 8.2 5.9 11.5 11 5.6 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) DUF4267 PF14087.1 CCF44174.1 - 9.1e-16 57.4 2.0 1.1e-15 57.2 1.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) zf-RING_5 PF14634.1 CCF44175.1 - 4.1e-06 26.4 0.8 4.1e-06 26.4 0.6 2.6 2 2 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.1 CCF44175.1 - 1.5e-05 24.7 6.2 1.5e-05 24.7 4.3 2.5 3 1 0 3 3 2 1 Ring finger domain zf-RING_UBOX PF13445.1 CCF44175.1 - 0.00013 21.5 4.1 0.00043 19.9 0.0 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.1 CCF44175.1 - 0.00074 19.4 0.4 0.00074 19.4 0.3 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 CCF44175.1 - 0.0017 18.4 6.3 0.0017 18.4 4.4 2.1 1 1 1 2 2 2 1 RING-H2 zinc finger zf-C3HC4_4 PF15227.1 CCF44175.1 - 0.004 16.9 2.1 0.0047 16.7 0.2 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.1 CCF44175.1 - 0.018 14.7 4.9 0.018 14.7 3.4 2.8 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CCF44175.1 - 0.023 14.5 3.3 0.055 13.3 2.3 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger NADH-G_4Fe-4S_3 PF10588.4 CCF44175.1 - 0.074 12.2 1.3 0.18 11.1 0.9 1.6 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region zf-C3HC4 PF00097.20 CCF44175.1 - 0.42 10.3 5.8 0.15 11.7 1.2 2.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.2 CCF44175.1 - 2.6 7.9 9.0 22 4.9 2.2 2.6 1 1 1 2 2 2 0 Double zinc ribbon Nop14 PF04147.7 CCF44175.1 - 5 4.9 10.7 8.1 4.2 7.4 1.3 1 0 0 1 1 1 0 Nop14-like family MFS_1 PF07690.11 CCF44176.1 - 4.6e-36 124.2 36.3 4.6e-36 124.2 25.2 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily FGGY_N PF00370.16 CCF44176.1 - 0.0081 15.4 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain adh_short PF00106.20 CCF44177.1 - 1.5e-25 90.0 1.1 1.5e-25 90.0 0.8 1.5 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF44177.1 - 2.6e-23 83.0 0.0 3.6e-23 82.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF44177.1 - 3.1e-10 40.0 0.2 5e-10 39.3 0.1 1.4 1 1 0 1 1 1 1 KR domain Fungal_trans_2 PF11951.3 CCF44178.1 - 1.7e-16 59.8 0.0 2.5e-15 55.9 0.0 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF44178.1 - 3.8e-06 26.7 13.9 7.1e-06 25.8 9.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Transketolase_N PF00456.16 CCF44179.1 - 2.2e-120 401.4 0.1 4.4e-120 400.4 0.0 1.5 2 0 0 2 2 2 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 CCF44179.1 - 1.9e-37 128.5 0.0 4.5e-37 127.2 0.0 1.7 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DXP_synthase_N PF13292.1 CCF44179.1 - 5.3e-08 32.1 0.0 1.1e-06 27.7 0.0 2.3 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.15 CCF44179.1 - 3.7e-07 29.1 0.5 5.8e-07 28.5 0.3 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component Transketolase_C PF02780.15 CCF44179.1 - 1.4e-06 28.2 0.0 3e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain TPP_enzyme_C PF02775.16 CCF44179.1 - 0.0026 17.3 1.6 0.029 13.9 1.2 2.6 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain AsmA_2 PF13502.1 CCF44179.1 - 0.058 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 AsmA-like C-terminal region NmrA PF05368.8 CCF44181.1 - 1.5e-23 83.2 0.0 1.9e-23 82.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF44181.1 - 4.5e-19 69.1 0.4 7.1e-19 68.5 0.3 1.3 1 0 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 CCF44181.1 - 7.6e-08 31.7 0.1 1.3e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase Epimerase PF01370.16 CCF44181.1 - 8.2e-08 31.9 0.0 1.7e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.15 CCF44181.1 - 4.1e-06 26.7 0.1 9.5e-06 25.5 0.1 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.19 CCF44181.1 - 1e-05 25.8 0.3 3.7e-05 24.0 0.1 2.1 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.12 CCF44181.1 - 5.1e-05 22.2 0.4 9.1e-05 21.4 0.1 1.5 2 0 0 2 2 2 1 RmlD substrate binding domain 3Beta_HSD PF01073.14 CCF44181.1 - 0.00031 19.5 0.1 0.00065 18.4 0.0 1.6 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family 3HCDH_N PF02737.13 CCF44181.1 - 0.00073 19.2 0.5 0.0014 18.3 0.3 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DFP PF04127.10 CCF44181.1 - 0.0022 17.6 2.1 0.0054 16.3 0.4 2.1 2 1 1 3 3 3 1 DNA / pantothenate metabolism flavoprotein NAD_binding_2 PF03446.10 CCF44181.1 - 0.0023 17.7 0.4 0.0073 16.1 0.1 1.9 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 CCF44181.1 - 0.0026 18.1 0.3 0.0065 16.8 0.2 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.13 CCF44181.1 - 0.0026 17.7 0.2 0.006 16.5 0.2 1.6 1 0 0 1 1 1 1 TrkA-N domain Shikimate_DH PF01488.15 CCF44181.1 - 0.018 15.1 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 CCF44181.1 - 0.028 13.5 0.1 0.048 12.8 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.17 CCF44181.1 - 0.03 14.8 0.3 0.068 13.6 0.1 1.6 2 0 0 2 2 1 0 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_7 PF13241.1 CCF44181.1 - 0.031 14.5 0.1 0.11 12.8 0.0 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding NAD_binding_4 PF07993.7 CCF44181.1 - 0.06 12.2 0.1 0.13 11.2 0.0 1.6 2 0 0 2 2 2 0 Male sterility protein K_oxygenase PF13434.1 CCF44181.1 - 0.19 10.6 1.2 1.9 7.3 0.1 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Citrate_synt PF00285.16 CCF44182.1 - 5e-114 380.7 0.0 6.4e-114 380.3 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase DnaJ-X PF14308.1 CCF44183.1 - 2.1e-74 249.2 1.8 2.1e-74 249.2 1.2 1.9 2 0 0 2 2 2 1 X-domain of DnaJ-containing SopA PF13981.1 CCF44183.1 - 0.12 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 SopA-like central domain Peptidase_S8 PF00082.17 CCF44184.1 - 4.6e-27 94.8 0.5 6.8e-27 94.3 0.3 1.2 1 0 0 1 1 1 1 Subtilase family Kri1 PF05178.7 CCF44185.1 - 1.9e-26 92.2 23.9 1.9e-26 92.2 16.6 5.3 6 1 0 6 6 6 1 KRI1-like family Kri1_C PF12936.2 CCF44185.1 - 4.5e-25 87.4 0.0 4.5e-25 87.4 0.0 4.4 5 1 0 5 5 5 1 KRI1-like family C-terminal TMEM154 PF15102.1 CCF44186.1 - 0.13 11.9 0.0 0.14 11.8 0.0 1.1 1 0 0 1 1 1 0 TMEM154 protein family OTCace_N PF02729.16 CCF44187.1 - 8.3e-43 145.4 0.0 1.2e-42 144.8 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.19 CCF44187.1 - 7.9e-36 123.3 0.0 1.5e-35 122.3 0.0 1.5 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Pyridox_oxidase PF01243.15 CCF44188.1 - 0.0017 18.3 0.1 0.0037 17.2 0.0 1.6 1 1 1 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Macoilin PF09726.4 CCF44189.1 - 2.2 6.4 8.9 2.8 6.1 6.1 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF2628 PF10947.3 CCF44190.1 - 0.27 11.0 3.4 5.6 6.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2628) Aldo_ket_red PF00248.16 CCF44191.1 - 3.6e-54 183.5 0.0 4.4e-54 183.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Death PF00531.17 CCF44191.1 - 0.00099 18.8 0.0 1.5 8.6 0.0 3.3 3 0 0 3 3 3 2 Death domain Dak1_2 PF13684.1 CCF44191.1 - 0.12 11.2 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Dihydroxyacetone kinase family COesterase PF00135.23 CCF44192.1 - 1.2e-49 169.4 1.9 2.7e-48 165.0 1.3 2.0 1 1 0 1 1 1 1 Carboxylesterase family F-box-like PF12937.2 CCF44193.1 - 2.7e-12 46.1 0.9 7.2e-12 44.8 0.6 1.8 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 CCF44193.1 - 2.3e-11 43.0 6.2 0.017 14.7 0.0 6.9 5 2 2 7 7 7 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CCF44193.1 - 5.5e-09 35.6 19.8 0.006 16.3 0.3 6.3 4 2 2 6 6 6 4 Leucine rich repeat LRR_6 PF13516.1 CCF44193.1 - 4.3e-08 32.4 20.9 1.1 9.4 0.0 11.9 13 1 1 14 14 14 1 Leucine Rich repeat LRR_1 PF00560.28 CCF44193.1 - 4.4e-05 22.9 28.3 12 6.4 0.0 10.7 9 3 0 9 9 9 2 Leucine Rich Repeat F-box PF00646.28 CCF44193.1 - 5.7e-05 22.6 2.3 8.6e-05 22.0 0.2 2.4 2 0 0 2 2 2 1 F-box domain RNase_T PF00929.19 CCF44194.1 - 2.4e-14 53.9 0.0 1.8e-09 38.0 0.0 2.3 1 1 1 2 2 2 2 Exonuclease AAA_11 PF13086.1 CCF44196.1 - 8.3e-13 48.4 0.0 1.3e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CCF44196.1 - 1.2e-09 37.7 0.0 3.8e-09 36.1 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 CCF44196.1 - 1.5e-06 27.9 0.0 2.6e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF44196.1 - 0.0014 18.6 0.4 0.036 14.0 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain DUF2075 PF09848.4 CCF44196.1 - 0.0039 16.2 0.0 0.012 14.6 0.0 1.7 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.10 CCF44196.1 - 0.0057 16.5 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_17 PF13207.1 CCF44196.1 - 0.049 14.4 0.0 0.18 12.6 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 CCF44196.1 - 0.061 12.7 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Helicase_RecD PF05127.9 CCF44196.1 - 0.062 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Helicase Glyco_hydro_12 PF01670.11 CCF44197.1 - 1.9e-11 44.0 0.4 3.1e-11 43.2 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 12 NACHT PF05729.7 CCF44198.1 - 8.7e-11 41.7 0.0 1.2e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 CCF44198.1 - 0.0013 18.8 0.0 0.0027 17.7 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.17 CCF44198.1 - 0.0035 16.2 0.0 0.0053 15.6 0.0 1.4 1 1 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.1 CCF44198.1 - 0.0047 17.0 0.0 0.0087 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain Syntaxin_2 PF14523.1 CCF44198.1 - 0.013 15.4 1.6 0.026 14.5 0.2 1.9 2 0 0 2 2 2 0 Syntaxin-like protein AAA_14 PF13173.1 CCF44198.1 - 0.044 13.6 0.0 0.11 12.4 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_35 PF14516.1 CCF44198.1 - 0.067 11.8 0.1 0.15 10.6 0.0 1.5 2 0 0 2 2 2 0 AAA-like domain p450 PF00067.17 CCF44199.1 - 6.4e-62 209.5 0.0 7.6e-62 209.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 F420_oxidored PF03807.12 CCF44199.1 - 0.087 13.2 0.0 0.14 12.5 0.0 1.2 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent PepSY_2 PF13670.1 CCF44201.1 - 0.084 12.7 0.9 0.26 11.2 0.6 1.8 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain RskA PF10099.4 CCF44201.1 - 0.19 11.4 6.2 4.2 7.0 1.2 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF605 PF04652.11 CCF44202.1 - 0.0097 15.3 10.6 0.012 14.9 7.3 1.1 1 0 0 1 1 1 1 Vta1 like CDC45 PF02724.9 CCF44202.1 - 0.23 9.4 8.1 0.31 9.0 5.6 1.1 1 0 0 1 1 1 0 CDC45-like protein p450 PF00067.17 CCF44203.1 - 1.1e-51 175.7 0.0 1.4e-51 175.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cutinase PF01083.17 CCF44205.1 - 7.5e-19 68.1 0.1 1e-18 67.7 0.0 1.2 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.6 CCF44205.1 - 0.0023 17.3 0.0 0.0037 16.7 0.0 1.2 1 0 0 1 1 1 1 PE-PPE domain PX PF00787.19 CCF44206.1 - 7.6e-20 70.8 0.0 2.7e-19 69.0 0.0 2.0 2 0 0 2 2 2 1 PX domain Vps5 PF09325.5 CCF44206.1 - 6.2e-16 58.3 12.6 1.2e-10 41.0 0.2 2.1 2 0 0 2 2 2 2 Vps5 C terminal like Ndc1_Nup PF09531.5 CCF44206.1 - 2.5 6.3 4.7 4 5.7 3.3 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TPR_1 PF00515.23 CCF44207.1 - 3.8e-34 114.9 19.6 1.9e-05 24.0 0.5 11.3 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_11 PF13414.1 CCF44207.1 - 1.5e-29 101.4 34.5 8.8e-10 38.0 3.0 11.5 9 6 4 13 13 13 7 TPR repeat TPR_2 PF07719.12 CCF44207.1 - 7.2e-29 97.3 34.3 0.0002 21.0 0.5 12.7 13 0 0 13 13 13 8 Tetratricopeptide repeat TPR_8 PF13181.1 CCF44207.1 - 1.1e-28 96.7 19.3 1.6e-05 24.3 0.6 11.3 12 0 0 12 12 12 7 Tetratricopeptide repeat TPR_12 PF13424.1 CCF44207.1 - 2e-20 72.4 36.6 8.4e-08 32.0 3.0 11.0 8 3 4 13 13 13 7 Tetratricopeptide repeat TPR_7 PF13176.1 CCF44207.1 - 2.8e-18 64.1 28.9 0.00015 21.3 0.1 10.9 13 0 0 13 13 12 6 Tetratricopeptide repeat TPR_19 PF14559.1 CCF44207.1 - 2e-17 63.2 23.5 0.00013 22.2 0.0 11.0 11 1 2 13 13 12 4 Tetratricopeptide repeat TPR_14 PF13428.1 CCF44207.1 - 4.2e-15 54.8 36.3 0.0032 17.9 0.0 14.1 13 3 3 16 16 15 3 Tetratricopeptide repeat TPR_17 PF13431.1 CCF44207.1 - 2.8e-12 45.7 7.7 0.28 11.4 0.0 10.5 11 0 0 11 11 10 3 Tetratricopeptide repeat Apc3 PF12895.2 CCF44207.1 - 5e-09 36.1 18.8 0.029 14.5 0.6 7.5 6 1 1 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 CCF44207.1 - 7.9e-09 35.9 44.5 0.021 15.5 0.0 11.4 10 2 3 13 13 13 5 Tetratricopeptide repeat TPR_6 PF13174.1 CCF44207.1 - 3.4e-07 30.2 26.5 0.027 14.9 0.0 12.2 14 1 0 14 14 13 1 Tetratricopeptide repeat TPR_10 PF13374.1 CCF44207.1 - 0.00073 19.3 31.2 0.12 12.2 0.1 9.0 11 0 0 11 11 8 2 Tetratricopeptide repeat SUV3_C PF12513.3 CCF44207.1 - 0.078 12.4 1.5 0.36 10.2 0.0 3.0 4 0 0 4 4 4 0 Mitochondrial degradasome RNA helicase subunit C terminal TPR_3 PF07720.7 CCF44207.1 - 3.2 7.6 9.7 0.54 10.1 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat 2OG-FeII_Oxy PF03171.15 CCF44209.1 - 2.3e-13 50.2 0.0 4e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 CCF44209.1 - 4.3e-12 46.5 0.0 7.2e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Fungal_trans_2 PF11951.3 CCF44210.1 - 0.00029 19.5 0.0 0.00038 19.1 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain RRM_1 PF00076.17 CCF44211.1 - 1.7e-14 53.2 0.0 2.6e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF44211.1 - 4.3e-13 49.0 0.0 6.3e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF44211.1 - 3.3e-05 23.6 0.0 5.1e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Imm32 PF15579.1 CCF44212.1 - 0.85 9.2 5.8 8.5 6.0 0.0 4.3 4 1 1 5 5 5 0 Immunity protein 32 Aconitase PF00330.15 CCF44213.1 - 1.7e-178 593.8 0.1 1.7e-178 593.8 0.1 1.4 2 0 0 2 2 2 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 CCF44213.1 - 3.7e-45 153.2 0.0 6.5e-45 152.4 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain MARVEL PF01284.18 CCF44214.1 - 2.7e-16 59.6 20.0 3.7e-16 59.2 13.8 1.1 1 0 0 1 1 1 1 Membrane-associating domain FA_desaturase PF00487.19 CCF44214.1 - 0.43 9.9 9.5 0.53 9.6 6.6 1.2 1 0 0 1 1 1 0 Fatty acid desaturase OCD_Mu_crystall PF02423.10 CCF44215.1 - 4.9e-09 35.3 0.1 6.5e-09 34.9 0.1 1.1 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.15 CCF44215.1 - 0.00012 22.1 0.2 0.0002 21.4 0.1 1.2 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GATase PF00117.23 CCF44216.1 - 1.2e-37 129.2 0.0 5.1e-37 127.1 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.17 CCF44216.1 - 7.1e-34 115.4 0.0 1.5e-33 114.3 0.0 1.6 1 0 0 1 1 1 1 GMP synthase C terminal domain NAD_synthase PF02540.12 CCF44216.1 - 1.5e-08 33.8 0.0 4.1e-06 25.8 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.8 CCF44216.1 - 5.3e-08 32.5 0.0 1.2e-07 31.3 0.0 1.6 1 1 0 1 1 1 1 Peptidase C26 tRNA_Me_trans PF03054.11 CCF44216.1 - 0.0025 16.4 0.0 0.0055 15.3 0.0 1.5 2 0 0 2 2 2 1 tRNA methyl transferase Asn_synthase PF00733.16 CCF44216.1 - 0.0073 15.8 0.0 0.014 14.9 0.0 1.4 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.8 CCF44216.1 - 0.0088 15.3 0.0 0.055 12.7 0.0 2.0 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC ThiI PF02568.9 CCF44216.1 - 0.013 15.0 0.0 0.027 13.9 0.0 1.5 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) PAPS_reduct PF01507.14 CCF44216.1 - 0.038 13.7 0.0 0.061 13.1 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Arginosuc_synth PF00764.14 CCF44216.1 - 0.058 12.4 0.1 0.095 11.7 0.0 1.3 1 0 0 1 1 1 0 Arginosuccinate synthase ATP_bind_3 PF01171.15 CCF44216.1 - 0.13 11.7 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 PP-loop family Mito_carr PF00153.22 CCF44217.1 - 8e-48 160.0 6.2 5.5e-20 70.8 0.1 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein JAB PF01398.16 CCF44219.1 - 1.8e-06 27.6 0.9 0.00014 21.6 0.7 2.2 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MFS_1 PF07690.11 CCF44220.1 - 4e-31 108.0 23.5 5e-31 107.6 16.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily VKOR PF07884.9 CCF44220.1 - 0.026 14.3 0.4 0.026 14.3 0.2 3.7 3 1 1 4 4 4 0 Vitamin K epoxide reductase family Pam17 PF08566.5 CCF44220.1 - 0.069 12.8 1.1 0.93 9.1 0.0 2.7 3 0 0 3 3 3 0 Mitochondrial import protein Pam17 CRCB PF02537.10 CCF44220.1 - 0.25 11.2 9.2 0.068 13.0 1.5 3.3 3 0 0 3 3 3 0 CrcB-like protein DUF3054 PF11255.3 CCF44220.1 - 4 7.3 8.9 0.42 10.4 1.7 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3054) Alpha-amylase_C PF02806.13 CCF44221.1 - 1e-25 89.6 0.3 4.3e-25 87.6 0.1 2.2 3 0 0 3 3 3 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.19 CCF44221.1 - 7.6e-19 68.2 0.3 1.9e-14 53.8 0.1 2.7 1 1 1 2 2 2 2 Alpha amylase, catalytic domain CBM_48 PF02922.13 CCF44221.1 - 5.8e-17 61.5 0.0 1.5e-16 60.1 0.0 1.8 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) hDGE_amylase PF14701.1 CCF44221.1 - 0.097 11.5 0.2 0.3 9.9 0.0 1.7 2 0 0 2 2 2 0 glucanotransferase domain of human glycogen debranching enzyme TC1 PF15063.1 CCF44223.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Thyroid cancer protein 1 Raptor_N PF14538.1 CCF44224.1 - 1.4e-66 223.0 0.0 2.3e-66 222.4 0.0 1.3 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain Apo-CII PF05355.6 CCF44224.1 - 0.078 12.8 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Apolipoprotein C-II DUF347 PF03988.7 CCF44225.1 - 0.051 13.4 0.1 0.067 13.0 0.1 1.2 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) DUF2531 PF10748.4 CCF44226.1 - 0.1 11.8 0.5 0.27 10.4 0.1 1.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2531) Condensation PF00668.15 CCF44227.1 - 5.8e-26 91.0 0.6 1.6e-24 86.2 0.0 3.2 3 2 1 4 4 4 1 Condensation domain Ion_trans PF00520.26 CCF44228.1 - 0.062 12.5 9.5 0.33 10.1 6.4 2.1 2 0 0 2 2 2 0 Ion transport protein MFS_1 PF07690.11 CCF44231.1 - 1.7e-30 105.9 30.3 2.7e-30 105.2 21.0 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily PsbN PF02468.10 CCF44231.1 - 5.5 6.6 7.1 2.9 7.5 0.7 2.9 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) BSP_II PF05432.6 CCF44232.1 - 0.091 12.0 0.1 0.11 11.7 0.1 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Peptidase_M28 PF04389.12 CCF44233.1 - 1.3e-14 54.3 0.0 2.3e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 CCF44233.1 - 6.9e-07 28.8 0.2 0.00011 21.8 0.0 2.5 2 0 0 2 2 2 2 PA domain Peptidase_M20 PF01546.23 CCF44233.1 - 0.011 15.2 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 HTH_psq PF05225.11 CCF44234.1 - 1.4e-14 53.3 0.2 3.1e-14 52.2 0.2 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF44234.1 - 2.3e-12 46.5 0.5 7.9e-12 44.8 0.0 2.1 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.1 CCF44234.1 - 9e-05 21.9 0.0 0.00027 20.4 0.0 1.9 1 0 0 1 1 1 1 Homeodomain-like domain DDE_1 PF03184.14 CCF44234.1 - 0.0001 21.4 0.0 0.00026 20.2 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_28 PF13518.1 CCF44234.1 - 0.00037 20.4 0.1 0.0011 18.8 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_7 PF02796.10 CCF44234.1 - 0.00085 19.1 0.1 0.0017 18.1 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.1 CCF44234.1 - 0.0032 17.0 0.1 0.007 15.9 0.1 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_1 PF00126.22 CCF44234.1 - 0.053 13.2 0.9 0.1 12.3 0.6 1.5 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family SpoIIID PF12116.3 CCF44234.1 - 0.064 13.1 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Stage III sporulation protein D CENP-B_N PF04218.8 CCF44234.1 - 0.074 12.4 0.0 0.17 11.2 0.0 1.6 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_8 PF02954.14 CCF44234.1 - 0.12 11.9 0.5 0.74 9.3 0.0 2.4 1 1 1 2 2 2 0 Bacterial regulatory protein, Fis family HTH_Tnp_1 PF01527.15 CCF44234.1 - 0.24 11.3 1.2 0.52 10.2 0.0 2.2 3 0 0 3 3 3 0 Transposase NAD_binding_6 PF08030.7 CCF44235.1 - 4.7e-19 68.8 0.0 1.3e-16 60.9 0.0 2.3 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 CCF44235.1 - 4.8e-11 42.4 0.0 8.8e-10 38.4 0.0 2.2 1 1 0 1 1 1 1 FAD-binding domain Abhydrolase_5 PF12695.2 CCF44236.1 - 3.5e-11 43.0 0.2 1.6e-10 40.9 0.0 2.2 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF44236.1 - 1.1e-09 38.4 3.3 1.1e-09 38.4 2.3 2.1 1 1 1 2 2 2 1 Alpha/beta hydrolase family DUF1100 PF06500.6 CCF44236.1 - 6.7e-05 21.6 0.0 9.5e-05 21.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Peptidase_S9 PF00326.16 CCF44236.1 - 0.014 14.6 0.2 0.032 13.4 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family AXE1 PF05448.7 CCF44236.1 - 0.024 13.1 0.0 0.037 12.5 0.0 1.4 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.8 CCF44236.1 - 0.029 13.9 0.1 0.059 12.9 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_1 PF00561.15 CCF44236.1 - 0.085 12.4 0.2 0.36 10.3 0.2 2.0 1 1 0 2 2 2 0 alpha/beta hydrolase fold adh_short PF00106.20 CCF44237.1 - 1.8e-11 44.2 0.2 2.2e-11 43.9 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF44237.1 - 1.1e-07 31.7 0.0 1.3e-07 31.4 0.0 1.0 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.3 CCF44237.1 - 0.0017 18.1 0.1 0.0026 17.5 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Glyco_transf_8 PF01501.15 CCF44239.1 - 9.2e-17 61.2 0.0 2.3e-16 59.9 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.3 CCF44239.1 - 0.0028 17.0 0.0 0.0036 16.6 0.0 1.1 1 0 0 1 1 1 1 Mannosyltransferase putative Nucleotid_trans PF03407.11 CCF44239.1 - 0.098 12.4 0.0 0.17 11.6 0.0 1.3 1 1 0 1 1 1 0 Nucleotide-diphospho-sugar transferase LOH1CR12 PF10158.4 CCF44240.1 - 0.0097 15.6 1.0 0.32 10.7 0.2 2.2 2 0 0 2 2 2 2 Tumour suppressor protein Oxysterol_BP PF01237.13 CCF44241.1 - 7.9e-108 360.0 0.0 2.3e-107 358.5 0.0 1.7 2 0 0 2 2 2 1 Oxysterol-binding protein PH_8 PF15409.1 CCF44241.1 - 7.5e-39 131.6 1.0 2.5e-38 130.0 0.1 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.24 CCF44241.1 - 9.5e-05 22.5 0.0 0.00033 20.7 0.0 2.0 1 0 0 1 1 1 1 PH domain GOLD_2 PF13897.1 CCF44241.1 - 0.043 14.0 1.6 0.13 12.4 0.0 2.4 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking PH_11 PF15413.1 CCF44241.1 - 0.069 13.4 4.5 0.11 12.7 1.1 2.6 2 1 0 2 2 2 0 Pleckstrin homology domain INSIG PF07281.7 CCF44241.1 - 0.15 11.3 0.0 0.33 10.2 0.0 1.4 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) Zn_clus PF00172.13 CCF44243.1 - 6e-08 32.4 9.8 1.1e-07 31.6 6.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF44243.1 - 6.2e-08 31.6 0.3 9.1e-08 31.0 0.2 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain RTA1 PF04479.8 CCF44246.1 - 3.4e-11 43.0 4.6 1.3e-10 41.1 3.2 1.8 1 1 0 1 1 1 1 RTA1 like protein ADH_N PF08240.7 CCF44247.1 - 4.1e-21 74.7 0.2 6.9e-21 74.0 0.1 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain FAD_oxidored PF12831.2 CCF44248.1 - 8e-52 176.7 0.0 9.7e-52 176.4 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.17 CCF44248.1 - 0.0039 16.1 0.1 0.005 15.7 0.1 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A Trp_halogenase PF04820.9 CCF44248.1 - 0.011 14.4 0.0 0.014 14.0 0.0 1.1 1 0 0 1 1 1 0 Tryptophan halogenase HI0933_like PF03486.9 CCF44248.1 - 0.16 10.3 0.0 0.21 9.9 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Phe_hydrox_dim PF07976.7 CCF44250.1 - 1.5e-45 154.8 0.0 1.8e-45 154.5 0.0 1.1 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Bd3614_N PF14442.1 CCF44250.1 - 0.15 12.0 0.2 0.23 11.4 0.1 1.2 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal PTPLA PF04387.9 CCF44251.1 - 3.9e-47 159.7 10.2 3.9e-47 159.7 7.1 1.5 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA Glyco_tranf_2_3 PF13641.1 CCF44252.1 - 7.5e-16 58.6 0.0 1e-15 58.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 CCF44252.1 - 8.8e-07 28.3 0.0 2.2e-06 27.0 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 CCF44252.1 - 0.0018 18.0 0.0 0.0065 16.1 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase family 2 PTS_2-RNA PF01885.11 CCF44253.1 - 1.4e-34 119.0 0.0 1.6e-34 118.8 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Macoilin PF09726.4 CCF44254.1 - 0.075 11.3 3.4 0.088 11.0 2.4 1.1 1 0 0 1 1 1 0 Transmembrane protein dsrm PF00035.20 CCF44254.1 - 0.081 13.5 1.4 0.79 10.3 0.0 2.9 3 1 0 3 3 3 0 Double-stranded RNA binding motif TFIIA PF03153.8 CCF44254.1 - 2.7 7.7 6.6 3.5 7.4 4.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1574 PF07611.6 CCF44255.1 - 0.2 10.4 0.6 0.34 9.7 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1574) SRP54 PF00448.17 CCF44256.1 - 2.4e-53 180.5 0.1 4.1e-53 179.7 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.8 CCF44256.1 - 2.6e-10 40.1 1.7 4e-10 39.5 1.1 1.3 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.14 CCF44256.1 - 8.7e-07 28.9 0.1 1.8e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain ArgK PF03308.11 CCF44256.1 - 2.2e-05 23.3 0.0 5.2e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 ArgK protein CbiA PF01656.18 CCF44256.1 - 3.4e-05 23.3 0.1 9.1e-05 21.9 0.1 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain cobW PF02492.14 CCF44256.1 - 0.0036 16.7 0.1 0.0066 15.9 0.0 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.9 CCF44256.1 - 0.0048 16.6 0.2 0.014 15.1 0.1 1.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 CCF44256.1 - 0.012 15.5 0.0 0.032 14.1 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase SMC_N PF02463.14 CCF44256.1 - 0.039 13.1 0.0 0.063 12.5 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ABC_tran PF00005.22 CCF44256.1 - 0.039 14.2 1.3 0.12 12.6 0.1 2.3 2 2 0 2 2 2 0 ABC transporter AAA_33 PF13671.1 CCF44256.1 - 0.043 13.6 0.0 0.13 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CCF44256.1 - 0.051 13.5 0.1 0.14 12.1 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.1 CCF44256.1 - 0.06 13.4 0.1 2.2 8.4 0.1 2.9 2 1 0 2 2 2 0 AAA domain Motilin_assoc PF04643.7 CCF44258.1 - 0.12 11.9 0.4 0.23 10.9 0.3 1.4 1 0 0 1 1 1 0 Motilin/ghrelin-associated peptide Surp PF01805.15 CCF44260.1 - 3.3e-15 55.4 0.0 6.5e-15 54.5 0.0 1.5 1 0 0 1 1 1 1 Surp module NUDIX PF00293.23 CCF44262.1 - 1.7e-07 30.9 0.0 2.2e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Git3 PF11710.3 CCF44263.1 - 1.7e-08 34.3 2.7 1.9e-08 34.1 1.9 1.1 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Dicty_CAR PF05462.6 CCF44263.1 - 0.00011 21.2 3.1 0.00017 20.6 2.1 1.3 1 1 0 1 1 1 1 Slime mold cyclic AMP receptor DUF2157 PF09925.4 CCF44263.1 - 0.39 10.3 3.3 8 6.0 0.2 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2157) GDPD PF03009.12 CCF44264.1 - 4.3e-13 49.3 0.0 4.7e-13 49.2 0.0 1.1 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Amidohydro_4 PF13147.1 CCF44265.1 - 9.7e-15 55.3 0.0 1.7e-14 54.4 0.0 1.4 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 CCF44265.1 - 5.5e-10 39.4 0.1 5.6e-09 36.1 0.0 2.1 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 CCF44265.1 - 2.1e-07 30.5 0.0 4.7e-07 29.3 0.0 1.4 1 1 0 1 1 1 1 Amidohydrolase family Pkinase PF00069.20 CCF44267.1 - 5.9e-06 25.6 0.0 9.8e-06 24.8 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain DHDPS PF00701.17 CCF44270.1 - 9.7e-35 119.5 0.0 1.1e-34 119.3 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family zf-Di19 PF05605.7 CCF44271.1 - 0.11 12.6 4.3 0.5 10.5 3.0 2.1 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.1 CCF44271.1 - 4.2 7.9 17.1 20 5.7 0.4 4.5 3 1 0 3 3 3 0 C2H2-type zinc finger PHO4 PF01384.15 CCF44272.1 - 1.4e-25 89.6 3.1 1.6e-25 89.4 2.1 1.0 1 0 0 1 1 1 1 Phosphate transporter family DUF4044 PF13253.1 CCF44272.1 - 3.1 7.0 5.4 7.7 5.7 3.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4044) Cu-oxidase PF00394.17 CCF44273.1 - 4.6e-33 114.3 0.1 5.9e-32 110.7 0.1 2.0 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.10 CCF44273.1 - 2.1e-32 111.3 0.0 3.7e-31 107.3 0.0 2.1 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 CCF44273.1 - 0.015 14.8 0.6 0.24 10.9 0.1 2.8 2 1 0 2 2 2 0 Multicopper oxidase SNF2_N PF00176.18 CCF44275.1 - 1.4e-45 155.4 0.0 8.3e-45 152.8 0.0 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CCF44275.1 - 1.3e-15 56.9 0.3 1.2e-14 53.9 0.2 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF44275.1 - 0.0011 18.8 0.4 0.049 13.4 0.0 3.0 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit GSH_synth_ATP PF03917.12 CCF44276.1 - 1e-111 373.1 0.0 1.3e-111 372.8 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.10 CCF44276.1 - 7e-30 103.2 0.0 1.3e-29 102.3 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic glutathione synthase SSB PF00436.20 CCF44277.1 - 1.2e-19 70.0 0.0 1.5e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 Single-strand binding protein family HeLo PF14479.1 CCF44279.1 - 3e-18 66.3 0.7 6.5e-18 65.2 0.1 1.9 2 0 0 2 2 2 1 Prion-inhibition and propagation NACHT PF05729.7 CCF44279.1 - 5.9e-12 45.5 0.0 1.2e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.1 CCF44279.1 - 0.0017 18.4 0.0 0.0074 16.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CCF44279.1 - 0.0031 17.5 0.2 0.016 15.2 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.1 CCF44279.1 - 0.0048 16.3 0.1 0.02 14.2 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CCF44279.1 - 0.0073 16.0 0.0 0.098 12.4 0.0 2.6 2 0 0 2 2 2 1 Part of AAA domain AAA PF00004.24 CCF44279.1 - 0.013 15.7 0.0 0.03 14.5 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 CCF44279.1 - 0.095 12.8 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase MobB PF03205.9 CCF44279.1 - 0.097 12.3 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Vac14_Fig4_bd PF11916.3 CCF44281.1 - 3.1e-83 277.4 7.8 3.1e-83 277.4 5.4 1.7 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding TMF_TATA_bd PF12325.3 CCF44282.1 - 0.0034 17.0 2.1 0.037 13.7 0.1 2.2 1 1 0 2 2 2 1 TATA element modulatory factor 1 TATA binding COG2 PF06148.6 CCF44282.1 - 0.013 15.3 0.9 0.1 12.4 0.1 2.0 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Tropomyosin_1 PF12718.2 CCF44282.1 - 0.036 13.9 2.9 1.1 9.0 0.7 2.1 1 1 1 2 2 2 0 Tropomyosin like CENP-F_leu_zip PF10473.4 CCF44282.1 - 0.047 13.5 3.0 4.7 7.0 0.0 2.3 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 WEMBL PF05701.6 CCF44282.1 - 0.07 11.5 3.0 0.079 11.4 0.4 1.8 1 1 1 2 2 2 0 Weak chloroplast movement under blue light PspB PF06667.7 CCF44282.1 - 0.11 12.3 2.5 4.9 7.1 0.0 3.0 2 1 1 3 3 3 0 Phage shock protein B Takusan PF04822.8 CCF44282.1 - 0.14 11.9 1.6 1.1 9.0 0.1 2.4 2 0 0 2 2 2 0 Takusan CENP-Q PF13094.1 CCF44282.1 - 0.47 10.4 4.8 1.7 8.6 3.3 1.8 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DIRP PF06584.8 CCF44282.1 - 0.55 10.1 3.0 17 5.3 0.2 2.4 1 1 0 2 2 2 0 DIRP FUSC PF04632.7 CCF44282.1 - 2.1 6.6 4.8 2.3 6.5 3.4 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family BBE PF08031.7 CCF44283.1 - 2.2e-08 33.8 0.2 4.8e-08 32.7 0.1 1.5 1 0 0 1 1 1 1 Berberine and berberine like Cytokin-bind PF09265.5 CCF44283.1 - 0.047 12.8 0.3 0.07 12.2 0.2 1.1 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding FAD-oxidase_C PF02913.14 CCF44283.1 - 0.068 12.4 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 FAD linked oxidases, C-terminal domain Ank_2 PF12796.2 CCF44284.1 - 2.3e-24 85.5 0.0 2.8e-15 56.4 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 CCF44284.1 - 7.2e-20 69.7 0.0 1.3e-06 27.9 0.0 4.5 4 1 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.1 CCF44284.1 - 8.1e-17 60.8 0.0 2.4e-08 33.9 0.1 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF44284.1 - 2.3e-13 48.9 0.1 0.00018 21.4 0.0 4.4 4 1 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.1 CCF44284.1 - 1e-11 45.0 0.0 7.3e-06 26.3 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Methyltransf_2 PF00891.13 CCF44287.1 - 0.03 13.5 0.1 0.037 13.2 0.1 1.1 1 0 0 1 1 1 0 O-methyltransferase VGCC_alpha2 PF08473.6 CCF44287.1 - 0.038 13.7 0.0 0.047 13.4 0.0 1.2 1 0 0 1 1 1 0 Neuronal voltage-dependent calcium channel alpha 2acd Sugar_tr PF00083.19 CCF44288.1 - 8e-104 347.7 24.7 9.1e-104 347.5 17.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF44288.1 - 3.8e-26 91.6 29.6 1.1e-24 86.8 8.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.15 CCF44288.1 - 8.3e-05 20.8 0.4 8.3e-05 20.8 0.3 2.4 3 0 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.11 CCF44289.1 - 7.5e-19 67.6 6.5 7.5e-19 67.6 4.5 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF44289.1 - 9.8e-08 30.9 6.8 2.2e-07 29.8 4.7 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter ATG22 PF11700.3 CCF44289.1 - 0.00051 18.6 0.2 0.00051 18.6 0.1 2.5 1 1 2 3 3 3 2 Vacuole effluxer Atg22 like TRI12 PF06609.8 CCF44289.1 - 0.04 12.1 0.4 0.05 11.8 0.3 1.1 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) Folate_carrier PF01770.13 CCF44289.1 - 0.13 10.7 0.7 0.9 7.9 0.0 2.0 1 1 1 2 2 2 0 Reduced folate carrier Transp_cyt_pur PF02133.10 CCF44290.1 - 4.7e-29 101.2 15.4 5.9e-29 100.8 10.7 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Zn_clus PF00172.13 CCF44291.1 - 5.2e-09 35.8 12.4 7.9e-09 35.2 8.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mito_carr PF00153.22 CCF44292.1 - 8.3e-07 28.6 0.0 1.1e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial carrier protein NDUF_B12 PF08122.7 CCF44292.1 - 0.0017 18.0 0.3 0.83 9.4 0.1 2.1 2 0 0 2 2 2 2 NADH-ubiquinone oxidoreductase B12 subunit family ATP-synt_C PF00137.16 CCF44294.1 - 7.6e-28 96.2 27.5 1.2e-16 60.3 4.2 2.1 2 0 0 2 2 2 2 ATP synthase subunit C TctB PF07331.6 CCF44294.1 - 7.7 6.1 17.6 5.1e+02 0.2 11.8 2.2 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family Glyco_hydro_12 PF01670.11 CCF44295.1 - 1.3e-34 119.2 1.0 1.3e-34 119.2 0.7 1.5 1 1 1 2 2 2 1 Glycosyl hydrolase family 12 Bac_luciferase PF00296.15 CCF44296.1 - 5.9e-64 216.1 0.2 7.6e-64 215.7 0.2 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase MFS_1 PF07690.11 CCF44297.1 - 6.3e-28 97.5 29.1 9.1e-28 96.9 20.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Pyr_redox_3 PF13738.1 CCF44298.1 - 4.3e-19 69.3 0.0 7.7e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 CCF44298.1 - 2.3e-13 49.2 0.0 8.1e-13 47.4 0.0 1.9 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 CCF44298.1 - 1.8e-09 37.5 0.0 7.1e-09 35.5 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 CCF44298.1 - 1.5e-05 24.1 0.1 0.00086 18.3 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 CCF44298.1 - 0.00012 21.9 0.3 0.092 12.5 0.0 3.3 2 1 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.12 CCF44298.1 - 0.0072 15.4 0.1 0.023 13.8 0.0 1.7 2 0 0 2 2 2 1 Thi4 family DAO PF01266.19 CCF44298.1 - 0.011 14.6 0.0 2.2 7.0 0.0 2.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF44298.1 - 0.023 14.5 0.0 0.085 12.7 0.0 1.9 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF44298.1 - 0.16 12.4 0.2 22 5.5 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase OmdA PF13376.1 CCF44298.1 - 0.29 10.8 2.3 1.1 8.9 0.1 2.5 2 0 0 2 2 2 0 Bacteriocin-protection, YdeI or OmpD-Associated HI0933_like PF03486.9 CCF44298.1 - 1.3 7.3 2.2 7.2 4.9 0.3 2.4 3 0 0 3 3 3 0 HI0933-like protein Acyl_transf_1 PF00698.16 CCF44299.1 - 2.2e-54 184.9 0.0 5.6e-54 183.6 0.0 1.6 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.5 CCF44299.1 - 2.1e-45 154.6 0.6 2.5e-44 151.0 0.0 2.8 3 0 0 3 3 3 1 KR domain adh_short PF00106.20 CCF44299.1 - 7.9e-39 133.2 4.5 1.7e-38 132.1 0.0 3.1 3 0 0 3 3 3 1 short chain dehydrogenase PS-DH PF14765.1 CCF44299.1 - 8.1e-26 90.8 0.0 2.4e-25 89.3 0.0 1.7 1 1 0 1 1 1 1 Polyketide synthase dehydratase Methyltransf_12 PF08242.7 CCF44299.1 - 1.4e-20 73.5 0.0 4.2e-20 72.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF44299.1 - 7.1e-12 45.3 0.0 2.9e-11 43.3 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF44299.1 - 1.7e-11 44.4 0.0 4.3e-11 43.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF44299.1 - 3.7e-10 40.3 0.0 1.2e-09 38.6 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF44299.1 - 1.5e-09 37.6 0.0 3.4e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF44299.1 - 3.2e-07 29.6 0.0 6.1e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PP-binding PF00550.20 CCF44299.1 - 6.8e-06 26.2 0.1 1.5e-05 25.1 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Ketoacyl-synt_C PF02801.17 CCF44299.1 - 4.5e-05 23.2 0.3 0.00017 21.4 0.2 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_16 PF10294.4 CCF44299.1 - 0.00074 19.0 0.0 0.0015 18.0 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase NodS PF05401.6 CCF44299.1 - 0.012 14.9 0.0 0.035 13.5 0.0 1.7 1 0 0 1 1 1 0 Nodulation protein S (NodS) RrnaAD PF00398.15 CCF44299.1 - 0.041 12.9 0.0 0.087 11.8 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase 3Beta_HSD PF01073.14 CCF44299.1 - 0.47 9.1 0.0 0.8 8.3 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DREV PF05219.7 CCF44299.1 - 0.8 8.5 0.0 1.3 7.8 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Fiji_64_capsid PF05880.6 CCF44299.1 - 2 6.6 0.0 3 6.0 0.0 1.1 1 0 0 1 1 1 0 Fijivirus 64 kDa capsid protein p450 PF00067.17 CCF44300.1 - 5.4e-64 216.4 0.0 6.3e-64 216.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 KR PF08659.5 CCF44301.1 - 2.1e-62 210.0 0.0 7.6e-62 208.1 0.0 2.1 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.16 CCF44301.1 - 2.3e-53 181.5 0.0 3.9e-53 180.8 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.21 CCF44301.1 - 6.4e-53 179.8 0.6 6.4e-53 179.8 0.4 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain adh_short PF00106.20 CCF44301.1 - 8.6e-48 162.4 0.0 3.3e-47 160.5 0.0 2.1 1 0 0 1 1 1 1 short chain dehydrogenase PS-DH PF14765.1 CCF44301.1 - 1.6e-47 162.0 0.4 2.7e-47 161.3 0.3 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.17 CCF44301.1 - 1.7e-35 121.4 0.1 4e-35 120.2 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.20 CCF44301.1 - 8.9e-06 25.8 0.1 2.8e-05 24.3 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.18 CCF44301.1 - 4.1e-05 22.6 0.0 8.4e-05 21.6 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 CCF44301.1 - 0.00099 18.7 0.1 0.0051 16.4 0.1 2.2 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Pyr_redox_3 PF13738.1 CCF44302.1 - 0.015 15.3 0.0 0.025 14.6 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RabGAP-TBC PF00566.13 CCF44303.1 - 9e-20 71.0 0.0 1.5e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Astro_capsid PF03115.9 CCF44303.1 - 0.088 11.0 3.8 0.12 10.6 2.6 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Nop14 PF04147.7 CCF44303.1 - 0.17 9.7 11.0 0.23 9.3 7.6 1.1 1 0 0 1 1 1 0 Nop14-like family Y_phosphatase2 PF03162.8 CCF44307.1 - 1.8e-44 151.0 0.0 2.8e-44 150.4 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 CCF44307.1 - 5.5e-11 42.9 0.0 2.5e-09 37.5 0.0 2.2 1 1 1 2 2 2 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 CCF44307.1 - 0.0056 16.0 0.0 0.0078 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.15 CCF44307.1 - 0.0075 15.8 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Phage_lysis PF03245.8 CCF44308.1 - 0.022 14.7 0.6 0.052 13.5 0.4 1.6 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein COesterase PF00135.23 CCF44309.1 - 1.1e-95 321.3 0.0 1.5e-95 320.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF44309.1 - 5.9e-06 25.9 0.0 1.3e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF44309.1 - 0.0022 17.2 0.0 0.0041 16.3 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CCF44309.1 - 0.014 15.1 0.3 0.044 13.5 0.2 2.1 1 1 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_MA_2 PF13485.1 CCF44310.1 - 2.5e-05 24.3 0.0 5.1e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase MA superfamily Peptidase_M61 PF05299.7 CCF44310.1 - 0.074 13.0 0.1 0.88 9.5 0.1 2.2 1 1 0 1 1 1 0 M61 glycyl aminopeptidase DUF2268 PF10026.4 CCF44310.1 - 0.22 10.8 0.0 0.36 10.1 0.0 1.3 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) RasGAP PF00616.14 CCF44312.1 - 4.1e-55 186.5 0.0 7.3e-55 185.6 0.0 1.4 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.10 CCF44312.1 - 1.6e-29 102.4 7.2 3.9e-29 101.1 5.0 1.7 1 0 0 1 1 1 1 RasGAP C-terminus WD40 PF00400.27 CCF44314.1 - 1.5e-54 180.0 15.8 1.4e-09 37.4 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 CCF44314.1 - 5.9e-05 21.4 4.9 1.7 6.6 0.0 4.8 1 1 3 5 5 5 5 Nucleoporin Nup120/160 PQQ_2 PF13360.1 CCF44314.1 - 0.0071 15.8 1.2 2.3 7.6 0.1 3.0 3 1 0 3 3 3 2 PQQ-like domain Tfb4 PF03850.9 CCF44315.1 - 5.4e-58 196.4 0.6 6.6e-58 196.1 0.4 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 Cation_efflux PF01545.16 CCF44316.1 - 2.6e-31 108.7 5.7 3.4e-31 108.3 4.0 1.1 1 0 0 1 1 1 1 Cation efflux family PDR_CDR PF06422.7 CCF44317.1 - 0.0034 17.0 0.1 0.004 16.7 0.1 1.3 1 0 0 1 1 1 1 CDR ABC transporter Methyltransf_23 PF13489.1 CCF44318.1 - 8.1e-13 48.3 0.2 1.3e-12 47.7 0.2 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF44318.1 - 2.5e-06 27.8 0.0 3.7e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF44318.1 - 1.3e-05 25.6 0.0 2.1e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF44318.1 - 0.09 12.3 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.2 CCF44318.1 - 0.092 13.3 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain GPI-anchored PF10342.4 CCF44319.1 - 5e-16 58.9 1.7 5e-16 58.9 1.2 1.8 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Gly-zipper_OmpA PF13436.1 CCF44319.1 - 0.07 12.7 7.9 0.11 12.1 5.5 1.3 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Cupredoxin_1 PF13473.1 CCF44319.1 - 0.071 13.0 0.0 0.16 11.9 0.0 1.7 1 1 0 1 1 1 0 Cupredoxin-like domain Serglycin PF04360.7 CCF44319.1 - 1.2 8.8 5.8 2.6 7.7 3.6 1.9 1 1 0 1 1 1 0 Serglycin 2-oxoacid_dh PF00198.18 CCF44321.1 - 1.3e-37 129.2 0.0 1.4e-37 129.1 0.0 1.0 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) HLH PF00010.21 CCF44322.1 - 1.4e-17 63.1 1.4 3.5e-17 61.8 0.9 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Pcc1 PF09341.5 CCF44323.1 - 4.9e-27 93.7 0.4 5.9e-27 93.5 0.3 1.1 1 0 0 1 1 1 1 Transcription factor Pcc1 DSPn PF14671.1 CCF44324.1 - 3.2e-43 147.1 0.0 4.1e-41 140.2 0.0 2.7 3 0 0 3 3 3 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.15 CCF44324.1 - 1.7e-15 56.7 0.0 4.2e-15 55.4 0.0 1.6 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 CCF44324.1 - 1.1e-06 28.1 0.0 2.7e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 CCF44324.1 - 0.35 11.1 2.8 0.33 11.1 0.1 2.1 2 0 0 2 2 2 0 Tyrosine phosphatase family DUF3405 PF11885.3 CCF44325.1 - 5.1e-149 496.6 0.1 5.8e-149 496.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) TcpQ PF10671.4 CCF44325.1 - 0.093 12.6 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Toxin co-regulated pilus biosynthesis protein Q MIP PF00230.15 CCF44327.1 - 1.1e-40 139.5 9.3 1.3e-40 139.3 6.5 1.0 1 0 0 1 1 1 1 Major intrinsic protein HPP PF04982.8 CCF44328.1 - 2.4e-36 124.1 5.7 2.4e-36 124.1 4.0 1.6 2 0 0 2 2 2 1 HPP family Ycf66_N PF07444.6 CCF44328.1 - 0.11 12.1 3.5 1.5 8.5 0.2 2.8 3 0 0 3 3 3 0 Ycf66 protein N-terminus DUF3377 PF11857.3 CCF44328.1 - 0.75 9.4 6.6 0.21 11.2 1.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) PAF-AH_p_II PF03403.8 CCF44330.1 - 1.5e-35 122.2 0.0 2.1e-35 121.7 0.0 1.2 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_5 PF12695.2 CCF44330.1 - 2.6e-12 46.6 0.1 5.3e-12 45.7 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF44330.1 - 3.4e-05 23.8 1.2 0.00012 22.0 0.8 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 CCF44330.1 - 0.0026 16.7 0.0 0.2 10.5 0.0 2.1 2 0 0 2 2 2 2 Chlorophyllase enzyme Hydrolase_4 PF12146.3 CCF44330.1 - 0.015 15.1 0.0 0.038 13.8 0.0 1.6 1 0 0 1 1 1 0 Putative lysophospholipase Chlorophyllase PF07224.6 CCF44330.1 - 0.047 12.4 0.0 1.2 7.9 0.0 2.1 2 0 0 2 2 2 0 Chlorophyllase AA_permease_2 PF13520.1 CCF44331.1 - 6e-38 130.4 20.5 7.8e-38 130.1 14.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF44331.1 - 1.6e-22 79.4 22.5 2.2e-22 79.0 15.6 1.1 1 0 0 1 1 1 1 Amino acid permease Phage_holin_4 PF05105.7 CCF44331.1 - 0.2 11.3 3.0 0.42 10.2 0.8 2.4 1 1 1 2 2 2 0 Holin family DUF334 PF03904.8 CCF44331.1 - 1.6 8.0 3.2 1.2 8.3 0.9 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF334) adh_short_C2 PF13561.1 CCF44333.1 - 1.2e-30 107.0 0.3 1.4e-30 106.8 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF44333.1 - 6.3e-22 78.2 0.5 1e-21 77.5 0.3 1.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF44333.1 - 2.5e-06 27.2 0.2 4e-06 26.6 0.2 1.4 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.13 CCF44333.1 - 0.0054 16.4 0.3 0.0098 15.5 0.2 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HMG_CoA_synt_C PF08540.5 CCF44333.1 - 0.01 15.3 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A synthase C terminal 2-Hacid_dh_C PF02826.14 CCF44333.1 - 0.035 13.2 0.1 0.077 12.1 0.1 1.6 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.18 CCF44333.1 - 0.13 12.0 2.8 1.2 8.8 0.8 2.3 2 1 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TauD PF02668.11 CCF44334.1 - 2.4e-38 132.3 0.1 4.5e-38 131.3 0.0 1.4 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.7 CCF44334.1 - 3.4e-05 24.1 0.0 6.9e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF971) 2OG-FeII_Oxy_3 PF13640.1 CCF44334.1 - 0.028 14.9 0.0 0.028 14.9 0.0 2.3 3 0 0 3 3 3 0 2OG-Fe(II) oxygenase superfamily CsiD PF08943.5 CCF44334.1 - 0.13 11.1 0.0 0.22 10.3 0.0 1.3 1 0 0 1 1 1 0 CsiD Lustrin_cystein PF14625.1 CCF44335.1 - 1.4 9.0 21.2 0.036 14.1 5.4 2.8 2 1 0 2 2 2 0 Lustrin, cysteine-rich repeated domain Pol_alpha_B_N PF08418.5 CCF44335.1 - 3.3 7.1 6.3 6.3 6.2 4.3 1.4 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Granulin PF00396.13 CCF44335.1 - 5.3 7.2 31.6 1.7 8.7 2.8 4.0 3 1 1 4 4 4 0 Granulin DEP PF00610.16 CCF44336.1 - 4e-26 90.5 0.1 4.4e-21 74.3 0.0 3.2 2 1 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF1469 PF07332.6 CCF44336.1 - 0.24 11.1 1.7 0.49 10.1 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) Glyco_hydro_18 PF00704.23 CCF44337.1 - 4.8e-66 223.5 1.8 6e-66 223.2 1.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF187 PF02638.10 CCF44337.1 - 0.051 12.4 0.0 0.078 11.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase like GH101 adh_short PF00106.20 CCF44338.1 - 4.6e-33 114.4 0.4 6.8e-33 113.9 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF44338.1 - 6.5e-26 91.5 0.0 8.3e-26 91.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF44338.1 - 1.8e-15 57.0 0.7 3.7e-15 56.0 0.5 1.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF44338.1 - 3.2e-07 30.0 0.0 5.1e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 CCF44338.1 - 0.0019 17.9 0.6 0.0042 16.8 0.4 1.5 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase RmlD_sub_bind PF04321.12 CCF44338.1 - 0.012 14.4 0.1 0.027 13.3 0.1 1.6 1 0 0 1 1 1 0 RmlD substrate binding domain DUF1815 PF08844.5 CCF44338.1 - 0.015 14.9 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1815) NmrA PF05368.8 CCF44338.1 - 0.021 14.0 2.7 0.076 12.2 0.6 2.5 2 1 0 3 3 3 0 NmrA-like family CW_binding_2 PF04122.7 CCF44338.1 - 0.05 13.8 0.1 0.18 12.0 0.1 1.9 2 0 0 2 2 2 0 Putative cell wall binding repeat 2 NAD_binding_10 PF13460.1 CCF44338.1 - 0.078 12.9 2.4 0.18 11.8 0.8 2.0 2 1 0 2 2 2 0 NADH(P)-binding PRTase_1 PF11202.3 CCF44338.1 - 0.12 11.2 0.0 0.22 10.4 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase (PRTase) DUF3425 PF11905.3 CCF44340.1 - 2.4e-21 76.0 0.6 2.8e-21 75.8 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) AIRS_C PF02769.17 CCF44341.1 - 6.1e-24 84.7 0.0 1.8e-23 83.2 0.1 1.7 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain AIRS PF00586.19 CCF44341.1 - 1.5e-22 79.6 0.0 4.4e-22 78.1 0.0 1.9 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain PSI_PsaE PF02427.12 CCF44341.1 - 0.088 12.1 0.0 0.21 10.9 0.0 1.6 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IV / PsaE Nefa_Nip30_N PF10187.4 CCF44342.1 - 5.4e-24 84.3 10.4 1.4e-23 83.0 7.2 1.7 1 0 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 YcbB PF08664.5 CCF44342.1 - 0.024 14.4 0.5 0.039 13.7 0.3 1.2 1 0 0 1 1 1 0 YcbB domain MIF4G_like_2 PF09090.6 CCF44342.1 - 0.63 9.2 2.2 0.85 8.7 1.6 1.1 1 0 0 1 1 1 0 MIF4G like Aldo_ket_red PF00248.16 CCF44343.1 - 1.3e-61 207.9 0.0 1.6e-61 207.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family BT1 PF03092.11 CCF44344.1 - 0.42 9.2 5.4 0.69 8.5 3.7 1.2 1 0 0 1 1 1 0 BT1 family Virul_fac_BrkB PF03631.10 CCF44344.1 - 6.9 5.9 12.0 0.27 10.5 3.9 1.7 2 0 0 2 2 2 0 Virulence factor BrkB MFS_1 PF07690.11 CCF44345.1 - 8.8e-39 133.1 46.5 9.3e-39 133.1 30.8 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF4131 PF13567.1 CCF44345.1 - 4.5 6.6 17.7 1.4 8.3 1.9 4.3 3 1 0 4 4 4 0 Domain of unknown function (DUF4131) Fungal_trans PF04082.13 CCF44346.1 - 1.2e-12 47.3 0.0 1.7e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF44346.1 - 6.5e-09 35.5 10.0 1.5e-08 34.4 6.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Filament PF00038.16 CCF44347.1 - 7.2e-05 22.3 18.8 7.2e-05 22.3 13.0 4.5 2 1 2 4 4 4 1 Intermediate filament protein IncA PF04156.9 CCF44347.1 - 0.00026 20.6 63.0 0.0084 15.7 13.2 3.8 2 1 2 4 4 4 3 IncA protein Myosin_tail_1 PF01576.14 CCF44347.1 - 0.00036 18.4 29.3 0.00036 18.4 20.3 4.0 2 1 1 4 4 4 2 Myosin tail Tropomyosin_1 PF12718.2 CCF44347.1 - 0.0035 17.2 9.7 0.0035 17.2 6.7 5.4 4 1 2 6 6 5 2 Tropomyosin like TMF_DNA_bd PF12329.3 CCF44347.1 - 0.016 14.9 74.9 0.038 13.7 4.0 7.0 5 1 1 7 7 6 0 TATA element modulatory factor 1 DNA binding HALZ PF02183.13 CCF44347.1 - 0.038 13.7 0.4 0.038 13.7 0.3 6.8 6 1 1 7 7 7 0 Homeobox associated leucine zipper DivIC PF04977.10 CCF44347.1 - 0.1 12.0 54.9 0.067 12.6 2.2 7.2 6 2 1 7 7 7 0 Septum formation initiator Reo_sigmaC PF04582.7 CCF44347.1 - 0.19 10.8 15.8 0.22 10.6 4.6 2.4 1 1 2 3 3 3 0 Reovirus sigma C capsid protein TcdB_N PF12918.2 CCF44347.1 - 0.21 11.6 5.3 1.3 9.1 0.0 3.7 3 1 0 3 3 3 0 TcdB toxin N-terminal helical domain CCDC92 PF14916.1 CCF44347.1 - 0.45 10.1 0.0 0.45 10.1 0.0 4.1 5 1 1 6 6 5 0 Coiled-coil domain of unknown function ADIP PF11559.3 CCF44347.1 - 3.8 7.4 62.5 0.052 13.4 10.3 5.1 4 1 0 5 5 5 0 Afadin- and alpha -actinin-Binding TPR_MLP1_2 PF07926.7 CCF44347.1 - 5.1 6.8 62.3 0.67 9.6 7.7 4.5 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein TSC22 PF01166.13 CCF44347.1 - 7.9 6.5 28.5 0.55 10.2 1.7 5.3 5 0 0 5 5 5 0 TSC-22/dip/bun family Syntaxin PF00804.20 CCF44347.1 - 8.5 6.5 38.8 0.74 10.0 10.6 4.9 3 1 1 4 4 4 0 Syntaxin BLVR PF06375.6 CCF44348.1 - 0.072 12.9 6.0 0.13 12.1 4.1 1.4 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) Autoind_bind PF03472.10 CCF44350.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Autoinducer binding domain FlaG PF03646.10 CCF44352.1 - 0.13 12.4 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 FlaG protein CHCH PF06747.8 CCF44354.1 - 1.6e-06 27.8 2.4 2.5e-06 27.2 1.7 1.4 1 0 0 1 1 1 1 CHCH domain DUF1903 PF08991.5 CCF44354.1 - 7.3e-05 22.8 1.8 0.00012 22.1 1.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1903) Pet191_N PF10203.4 CCF44354.1 - 0.093 12.7 3.7 0.29 11.1 2.5 1.8 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 UPF0203 PF05254.7 CCF44354.1 - 0.1 12.4 4.2 1 9.2 2.5 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) Cmc1 PF08583.5 CCF44354.1 - 1.5 8.6 5.8 16 5.3 3.5 2.5 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Dynein_heavy PF03028.10 CCF44356.1 - 5.2e-107 358.6 0.0 8e-107 358.0 0.0 1.2 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_9 PF12781.2 CCF44356.1 - 5.1e-26 90.9 1.0 2.2e-25 88.8 0.1 2.1 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 Hemerythrin PF01814.18 CCF44356.1 - 0.0032 17.6 0.4 0.0088 16.2 0.0 1.9 2 0 0 2 2 2 1 Hemerythrin HHE cation binding domain Snapin_Pallidin PF14712.1 CCF44356.1 - 0.79 10.0 5.1 1.1 9.6 1.6 2.7 3 0 0 3 3 3 0 Snapin/Pallidin Sulfatase PF00884.18 CCF44357.1 - 3.5e-60 203.7 0.2 3.5e-60 203.7 0.1 1.4 2 0 0 2 2 2 1 Sulfatase Phosphodiest PF01663.17 CCF44357.1 - 3.3e-07 29.9 2.1 4.5e-06 26.2 1.4 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.12 CCF44357.1 - 0.0045 15.4 0.0 0.0072 14.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF1501 PF07394.7 CCF44357.1 - 0.087 11.6 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) LSM PF01423.17 CCF44358.1 - 2.6e-16 58.9 0.0 3.5e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 LSM domain PPR_2 PF13041.1 CCF44359.1 - 1.6e-07 31.1 0.2 1.8 8.6 0.0 5.1 4 1 1 5 5 5 3 PPR repeat family PPR_3 PF13812.1 CCF44359.1 - 3.7e-07 29.9 10.7 0.27 11.6 0.0 6.7 7 1 0 7 7 7 3 Pentatricopeptide repeat domain PPR PF01535.15 CCF44359.1 - 0.00027 20.7 8.1 1.3 9.1 0.1 4.6 6 0 0 6 6 6 3 PPR repeat DDE_Tnp_1_assoc PF13808.1 CCF44359.1 - 0.038 13.6 0.0 2.3 7.9 0.0 2.5 1 1 0 1 1 1 0 DDE_Tnp_1-associated PPR_1 PF12854.2 CCF44359.1 - 0.22 11.0 3.5 13 5.3 0.1 3.3 3 0 0 3 3 3 0 PPR repeat MFS_1 PF07690.11 CCF44360.1 - 1.8e-31 109.1 42.0 1.8e-31 109.1 29.1 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily EphA2_TM PF14575.1 CCF44362.1 - 8.7e-06 26.0 0.2 1.4e-05 25.4 0.1 1.3 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Rifin_STEVOR PF02009.11 CCF44362.1 - 0.00076 19.2 0.5 0.00098 18.8 0.3 1.1 1 0 0 1 1 1 1 Rifin/stevor family DUF1183 PF06682.7 CCF44362.1 - 0.0025 17.4 0.2 0.0029 17.2 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1183) GRP PF07172.6 CCF44362.1 - 0.0042 17.5 5.6 0.0051 17.2 3.4 1.4 1 1 0 1 1 1 1 Glycine rich protein family Syndecan PF01034.15 CCF44362.1 - 0.0063 16.1 0.8 0.011 15.3 0.5 1.4 1 0 0 1 1 1 1 Syndecan domain Herpes_gE PF02480.11 CCF44362.1 - 0.0065 14.7 0.1 0.0074 14.5 0.1 1.0 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E IncA PF04156.9 CCF44362.1 - 0.017 14.7 0.0 0.022 14.3 0.0 1.1 1 0 0 1 1 1 0 IncA protein Adeno_E3_CR2 PF02439.10 CCF44362.1 - 0.017 14.6 5.7 0.028 13.9 3.9 1.2 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF3609 PF12259.3 CCF44362.1 - 0.019 13.6 0.0 0.023 13.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3609) CD34_antigen PF06365.7 CCF44362.1 - 0.024 14.3 0.0 0.029 14.0 0.0 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family DAG1 PF05454.6 CCF44362.1 - 0.033 13.3 0.2 0.038 13.1 0.1 1.1 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Shisa PF13908.1 CCF44362.1 - 0.061 13.5 0.0 0.069 13.3 0.0 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator ASFV_J13L PF05568.6 CCF44362.1 - 0.093 12.2 0.5 0.15 11.6 0.2 1.5 1 1 0 1 1 1 0 African swine fever virus J13L protein Vpu PF00558.14 CCF44362.1 - 0.094 12.2 0.1 0.27 10.8 0.1 1.6 2 0 0 2 2 2 0 Vpu protein Protocadherin PF08374.6 CCF44362.1 - 0.15 11.6 0.3 0.18 11.4 0.2 1.1 1 0 0 1 1 1 0 Protocadherin P12 PF12669.2 CCF44362.1 - 0.25 11.5 4.9 0.45 10.7 3.4 1.4 1 0 0 1 1 1 0 Virus attachment protein p12 family YajC PF02699.10 CCF44362.1 - 0.31 10.7 2.3 0.49 10.1 1.4 1.5 1 1 0 1 1 1 0 Preprotein translocase subunit SKG6 PF08693.5 CCF44362.1 - 0.97 8.7 6.9 1.6 8.1 4.8 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain RCR PF12273.3 CCF44362.1 - 2 8.9 8.8 7 7.2 6.1 1.8 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red DUF2615 PF11027.3 CCF44364.1 - 0.013 15.4 0.0 0.015 15.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) Fun_ATP-synt_8 PF05933.8 CCF44364.1 - 0.02 14.9 0.4 0.027 14.4 0.3 1.2 1 0 0 1 1 1 0 Fungal ATP synthase protein 8 (A6L) DUF3043 PF11241.3 CCF44364.1 - 0.092 12.3 0.1 0.1 12.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) DUF3328 PF11807.3 CCF44364.1 - 0.1 12.2 0.2 0.13 11.9 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) DUF4149 PF13664.1 CCF44364.1 - 0.12 12.4 0.1 0.15 12.1 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4149) DUF4200 PF13863.1 CCF44366.1 - 0.96 9.4 34.7 0.82 9.6 10.8 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF4200) COG5 PF10392.4 CCF44366.1 - 2.1 8.3 7.3 0.52 10.2 0.8 2.4 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Bacillus_HBL PF05791.6 CCF44366.1 - 4.3 6.6 19.5 0.11 11.8 4.1 3.1 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Macoilin PF09726.4 CCF44366.1 - 8.1 4.5 34.6 0.067 11.4 16.5 2.3 2 1 1 3 3 3 0 Transmembrane protein GAS PF13851.1 CCF44366.1 - 9.6 5.3 27.4 9 5.4 10.0 3.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Sugar_tr PF00083.19 CCF44367.1 - 2.2e-27 95.7 19.9 2.5e-27 95.5 13.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF44367.1 - 9.8e-16 57.3 10.3 1.2e-15 57.0 7.2 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF44367.1 - 0.0019 16.6 16.9 0.0027 16.1 5.1 2.0 1 1 1 2 2 2 2 MFS/sugar transport protein MerC PF03203.9 CCF44367.1 - 0.31 11.4 5.3 0.11 12.9 0.4 2.0 1 1 0 2 2 2 0 MerC mercury resistance protein DUF1345 PF07077.6 CCF44367.1 - 0.31 10.5 3.4 0.49 9.9 0.1 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1345) RseC_MucC PF04246.7 CCF44367.1 - 1.9 8.0 5.9 0.19 11.3 0.6 1.8 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC ABC_membrane PF00664.18 CCF44369.1 - 5e-30 104.8 12.7 6.3e-30 104.5 8.8 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region Psu PF07455.6 CCF44369.1 - 0.044 13.2 0.0 0.078 12.4 0.0 1.3 1 0 0 1 1 1 0 Phage polarity suppression protein (Psu) DUF2628 PF10947.3 CCF44369.1 - 0.76 9.5 5.4 0.73 9.6 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2628) NADH-u_ox-rdase PF10785.4 CCF44369.1 - 1.8 8.8 4.8 2.3 8.5 0.3 2.9 2 2 0 2 2 2 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit AP_endonuc_2 PF01261.19 CCF44370.1 - 4.9e-26 91.3 0.2 7.6e-26 90.7 0.2 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Sox_N PF12444.3 CCF44370.1 - 0.49 11.5 4.7 1.3 10.2 3.3 1.8 1 0 0 1 1 1 0 Sox developmental protein N terminal DUF601 PF04642.7 CCF44370.1 - 3.9 6.7 14.5 6.1 6.1 10.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF601 DAGAT PF03982.8 CCF44371.1 - 7.7e-51 172.5 0.0 8.4e-51 172.4 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Sugar_tr PF00083.19 CCF44372.1 - 2e-69 234.3 29.2 2.3e-69 234.1 20.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF44372.1 - 1.4e-18 66.7 31.8 1.4e-18 66.7 22.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF44372.1 - 0.0063 16.2 0.3 0.0063 16.2 0.2 3.8 4 0 0 4 4 4 1 MFS_1 like family DUF1494 PF07379.6 CCF44374.1 - 0.068 13.0 1.7 0.11 12.4 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1494) Med15 PF09606.5 CCF44374.1 - 0.56 8.3 77.2 0.93 7.6 53.5 1.4 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CorA PF01544.13 CCF44374.1 - 2.4 7.1 8.4 4.3 6.2 5.8 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein adh_short PF00106.20 CCF44375.1 - 7.3e-20 71.5 3.7 3.3e-10 40.1 0.3 3.2 2 1 1 3 3 3 2 short chain dehydrogenase KR PF08659.5 CCF44375.1 - 1.6e-06 27.8 0.7 0.0012 18.4 0.2 2.5 1 1 0 2 2 2 2 KR domain NAD_binding_10 PF13460.1 CCF44375.1 - 5.7e-05 23.1 0.4 0.00013 22.0 0.1 1.8 2 1 0 2 2 2 1 NADH(P)-binding DUF1776 PF08643.5 CCF44375.1 - 0.00038 19.7 0.2 0.00053 19.2 0.1 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Saccharop_dh PF03435.13 CCF44375.1 - 0.025 13.5 0.0 0.035 13.0 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase Epimerase PF01370.16 CCF44375.1 - 0.045 13.1 0.0 0.12 11.8 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 CCF44375.1 - 0.12 12.1 0.1 0.24 11.2 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NmrA PF05368.8 CCF44377.1 - 1.3e-18 67.1 0.0 1.6e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF44377.1 - 7.8e-12 45.5 0.3 1.3e-11 44.8 0.1 1.5 1 1 1 2 2 2 1 NADH(P)-binding Semialdhyde_dh PF01118.19 CCF44377.1 - 0.0097 16.2 0.1 0.021 15.1 0.1 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 CCF44377.1 - 0.037 13.9 0.0 0.072 13.0 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.20 CCF44377.1 - 0.081 12.8 2.1 0.21 11.4 0.1 2.4 2 1 0 2 2 2 0 short chain dehydrogenase 3Beta_HSD PF01073.14 CCF44377.1 - 0.11 11.1 0.0 0.17 10.5 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family HAD_2 PF13419.1 CCF44378.1 - 3.3e-25 89.2 0.0 4.3e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CCF44378.1 - 1.2e-05 24.9 0.0 2.1e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 CCF44378.1 - 0.004 17.6 0.0 0.084 13.2 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF3226 PF11536.3 CCF44378.1 - 0.0048 16.3 0.0 0.007 15.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3226) DAGK_cat PF00781.19 CCF44379.1 - 2.5e-07 30.1 0.0 4.9e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain adh_short_C2 PF13561.1 CCF44380.1 - 8.7e-08 32.2 0.1 9.6e-08 32.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Ras PF00071.17 CCF44381.1 - 3e-39 133.9 0.0 7.8e-26 90.3 0.0 2.1 2 0 0 2 2 2 2 Ras family Miro PF08477.8 CCF44381.1 - 1.7e-12 47.9 0.0 3.9e-12 46.7 0.0 1.6 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 CCF44381.1 - 0.00036 19.8 0.0 0.0015 17.8 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 CCF44381.1 - 0.00041 20.2 0.0 0.0006 19.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CCF44381.1 - 0.0075 15.7 0.0 0.21 10.9 0.0 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 CCF44381.1 - 0.058 13.3 0.0 0.1 12.6 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain PRK PF00485.13 CCF44381.1 - 0.059 12.9 0.0 0.083 12.4 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family NEL PF14496.1 CCF44382.1 - 0.012 14.9 1.5 0.014 14.6 1.0 1.2 1 0 0 1 1 1 0 C-terminal novel E3 ligase, LRR-interacting SbcD_C PF12320.3 CCF44382.1 - 0.097 12.7 1.2 0.12 12.4 0.5 1.4 1 1 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain APG6 PF04111.7 CCF44382.1 - 0.45 9.5 2.3 0.5 9.3 1.6 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 Phage_lysis PF03245.8 CCF44382.1 - 0.61 10.0 4.4 0.9 9.5 2.9 1.4 1 1 0 1 1 1 0 Bacteriophage Rz lysis protein ABC2_membrane PF01061.19 CCF44383.1 - 5e-32 110.7 17.9 5e-32 110.7 12.4 1.4 2 0 0 2 2 2 1 ABC-2 type transporter PDR_CDR PF06422.7 CCF44383.1 - 3.6e-30 103.6 0.0 8.9e-30 102.4 0.0 1.7 1 0 0 1 1 1 1 CDR ABC transporter ABC_tran PF00005.22 CCF44383.1 - 2e-16 60.5 0.0 5.2e-16 59.1 0.0 1.7 2 0 0 2 2 2 1 ABC transporter ABC2_membrane_3 PF12698.2 CCF44383.1 - 1.4e-06 27.6 4.7 2.7e-06 26.6 3.2 1.5 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_25 PF13481.1 CCF44383.1 - 1e-05 25.0 0.0 2.3e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF44383.1 - 4.1e-05 23.6 0.1 7.3e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 CCF44383.1 - 6e-05 22.2 0.0 0.00011 21.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 CCF44383.1 - 0.00029 20.3 1.5 0.00044 19.7 0.2 2.0 2 0 0 2 2 1 1 P-loop containing region of AAA domain SMC_N PF02463.14 CCF44383.1 - 0.00031 20.0 0.0 0.12 11.5 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_33 PF13671.1 CCF44383.1 - 0.00072 19.4 0.0 0.0014 18.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain cobW PF02492.14 CCF44383.1 - 0.0017 17.8 0.1 0.0031 16.9 0.0 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_21 PF13304.1 CCF44383.1 - 0.0027 17.7 0.1 0.16 11.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 CCF44383.1 - 0.0036 17.6 0.0 0.007 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CCF44383.1 - 0.0074 17.1 0.0 0.018 15.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 CCF44383.1 - 0.016 15.1 0.1 0.037 13.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 CCF44383.1 - 0.025 14.7 0.1 0.054 13.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.1 CCF44383.1 - 0.027 14.7 0.0 0.044 14.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 CCF44383.1 - 0.04 13.5 0.2 0.08 12.5 0.1 1.5 1 0 0 1 1 1 0 NACHT domain SRP54 PF00448.17 CCF44383.1 - 0.12 11.7 0.1 0.19 11.1 0.1 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain UPF0079 PF02367.12 CCF44383.1 - 0.17 11.4 0.1 0.34 10.5 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 TRP PF06011.7 CCF44385.1 - 8.4e-31 106.9 3.5 6.3e-30 104.1 2.4 2.0 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 CCF44385.1 - 5.3e-24 84.8 0.0 7.9e-24 84.3 0.0 1.2 1 0 0 1 1 1 1 ML-like domain TrbL PF04610.9 CCF44385.1 - 0.39 10.3 9.6 0.2 11.3 1.9 2.2 2 0 0 2 2 2 0 TrbL/VirB6 plasmid conjugal transfer protein PAN_4 PF14295.1 CCF44386.1 - 0.00072 19.2 32.9 0.016 14.9 2.4 4.8 4 0 0 4 4 4 3 PAN domain HTH_psq PF05225.11 CCF44387.1 - 5.3e-12 45.0 0.0 7.6e-12 44.5 0.0 1.2 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF44387.1 - 6.5e-07 29.0 0.0 5.5e-06 26.1 0.0 2.0 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_30 PF13556.1 CCF44387.1 - 0.0017 17.9 0.0 0.0035 16.9 0.0 1.6 2 0 0 2 2 2 1 PucR C-terminal helix-turn-helix domain HTH_23 PF13384.1 CCF44387.1 - 0.0021 17.6 0.1 0.0044 16.6 0.1 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_8 PF02954.14 CCF44387.1 - 0.02 14.4 0.3 0.057 12.9 0.0 2.0 2 1 1 3 3 3 0 Bacterial regulatory protein, Fis family HTH_1 PF00126.22 CCF44387.1 - 0.088 12.5 0.2 0.16 11.7 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family Fungal_trans PF04082.13 CCF44388.1 - 2.5e-18 65.9 0.1 4e-18 65.2 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF44388.1 - 0.00043 20.1 7.4 0.00087 19.1 5.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pyr_redox PF00070.22 CCF44389.1 - 6.8e-14 52.0 1.8 3e-10 40.3 0.1 3.0 4 0 0 4 4 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CCF44389.1 - 3.6e-13 49.8 0.2 6.4e-13 49.0 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF44389.1 - 1.8e-05 23.8 6.5 0.0058 15.5 0.0 3.7 4 0 0 4 4 4 3 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 CCF44389.1 - 1.9e-05 24.7 2.0 0.051 13.6 0.2 3.0 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF44389.1 - 2e-05 24.3 1.9 0.075 12.8 0.0 3.8 4 0 0 4 4 4 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.7 CCF44389.1 - 0.003 16.5 0.7 0.029 13.3 0.0 2.5 3 0 0 3 3 3 1 Lycopene cyclase protein Trp_halogenase PF04820.9 CCF44389.1 - 0.047 12.3 2.8 8.1 4.9 0.7 3.0 2 1 0 3 3 3 0 Tryptophan halogenase Thi4 PF01946.12 CCF44389.1 - 0.074 12.1 0.6 4.8 6.2 0.0 2.4 2 0 0 2 2 2 0 Thi4 family Malic_M PF03949.10 CCF44389.1 - 0.085 12.4 2.3 0.43 10.0 0.0 2.6 2 1 0 2 2 2 0 Malic enzyme, NAD binding domain TrkA_N PF02254.13 CCF44389.1 - 0.089 12.7 1.1 14 5.6 0.0 3.1 3 1 0 3 3 3 0 TrkA-N domain ThiF PF00899.16 CCF44389.1 - 0.14 11.9 5.0 1.1 9.0 0.0 3.2 3 0 0 3 3 3 0 ThiF family Beta_helix PF13229.1 CCF44390.1 - 5.2e-13 49.0 11.5 2.4e-09 37.1 1.7 2.4 1 1 1 2 2 2 2 Right handed beta helix region NosD PF05048.8 CCF44390.1 - 0.004 16.3 12.0 0.049 12.7 0.7 2.4 1 1 0 2 2 2 2 Periplasmic copper-binding protein (NosD) DUF3395 PF11875.3 CCF44391.1 - 1.4e-24 86.4 0.0 1.9e-24 86.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) Fungal_trans_2 PF11951.3 CCF44392.1 - 5.6e-07 28.4 0.0 7.5e-07 28.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain C5-epim_C PF06662.8 CCF44392.1 - 0.051 12.8 0.1 0.15 11.3 0.0 1.7 2 0 0 2 2 2 0 D-glucuronyl C5-epimerase C-terminus Transaldolase PF00923.14 CCF44393.1 - 4.2e-94 314.8 0.8 4.8e-94 314.7 0.5 1.0 1 0 0 1 1 1 1 Transaldolase Robl_LC7 PF03259.12 CCF44394.1 - 6.9e-09 35.1 0.0 9.8e-06 25.0 0.0 2.1 2 0 0 2 2 2 2 Roadblock/LC7 domain Acetyltransf_1 PF00583.19 CCF44395.1 - 5e-09 36.0 0.0 7.8e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF44395.1 - 5.1e-06 26.5 0.1 8.2e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF44395.1 - 0.014 15.1 0.0 0.031 14.0 0.0 1.5 2 0 0 2 2 2 0 FR47-like protein Acetyltransf_10 PF13673.1 CCF44395.1 - 0.015 15.4 0.0 0.023 14.8 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF4231 PF14015.1 CCF44395.1 - 0.038 13.9 0.0 0.06 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) Mec-17 PF05301.6 CCF44395.1 - 0.17 11.8 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 Touch receptor neuron protein Mec-17 ATP-grasp_2 PF08442.5 CCF44396.1 - 6.3e-18 64.9 0.0 8.2e-18 64.5 0.0 1.1 1 0 0 1 1 1 1 ATP-grasp domain adh_short_C2 PF13561.1 CCF44397.1 - 8.4e-12 45.3 0.0 9.7e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Kin17_mid PF10357.4 CCF44401.1 - 2.7e-49 166.0 1.4 2.7e-49 166.0 1.0 2.2 3 0 0 3 3 3 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.3 CCF44401.1 - 1.3e-05 25.1 2.4 2.8e-05 24.1 1.6 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CCF44401.1 - 2.1e-05 24.5 3.2 4.3e-05 23.5 2.2 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 CCF44401.1 - 0.0038 17.3 0.4 0.0038 17.3 0.3 2.3 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) NOD PF06816.8 CCF44401.1 - 0.075 12.1 0.0 0.16 11.0 0.0 1.5 1 0 0 1 1 1 0 NOTCH protein Ecl1 PF12855.2 CCF44401.1 - 0.091 12.0 0.2 0.21 10.9 0.2 1.5 1 0 0 1 1 1 0 Life-span regulatory factor Spt4 PF06093.8 CCF44402.1 - 2.5e-33 113.8 0.3 3e-33 113.5 0.2 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Coronavirus_5 PF05528.6 CCF44402.1 - 0.061 13.1 0.9 0.28 11.0 0.1 2.1 1 1 1 2 2 2 0 Coronavirus gene 5 protein TBCC PF07986.7 CCF44402.1 - 0.11 11.8 0.1 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Tubulin binding cofactor C Cys_rich_CPXG PF14255.1 CCF44402.1 - 0.23 11.2 3.4 18 5.2 0.0 2.6 2 1 0 2 2 2 0 Cysteine-rich CPXCG Metallophos PF00149.23 CCF44404.1 - 6.6e-39 133.3 0.1 1.1e-38 132.6 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.7 CCF44404.1 - 1.5e-30 105.0 3.2 3.6e-30 103.8 1.6 2.1 2 0 0 2 2 2 1 PPP5 TPR repeat region TPR_11 PF13414.1 CCF44404.1 - 1.6e-25 88.5 3.2 2.4e-17 62.3 0.8 2.4 1 1 2 3 3 3 3 TPR repeat TPR_1 PF00515.23 CCF44404.1 - 6.1e-18 63.5 1.8 0.00024 20.5 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 CCF44404.1 - 5.5e-12 44.6 0.5 0.019 14.8 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.1 CCF44404.1 - 2.5e-06 27.2 3.1 0.14 12.4 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 CCF44404.1 - 0.00061 20.2 0.3 1.6 9.5 0.0 3.1 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 CCF44404.1 - 0.0028 17.4 0.0 0.24 11.2 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 CCF44404.1 - 0.013 15.8 0.1 2.8 8.3 0.1 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 CCF44404.1 - 0.016 15.8 0.2 4.9 7.9 0.0 2.8 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 CCF44404.1 - 0.03 14.2 0.1 4.3 7.3 0.0 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat UPF0278 PF08745.6 CCF44404.1 - 0.086 12.0 0.2 0.14 11.3 0.1 1.2 1 0 0 1 1 1 0 UPF0278 family TPR_8 PF13181.1 CCF44404.1 - 0.11 12.2 1.2 39 4.3 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Es2 PF09751.4 CCF44405.1 - 1e-98 331.4 2.2 3e-98 329.9 1.5 1.6 1 1 0 1 1 1 1 Nuclear protein Es2 ABC1 PF03109.11 CCF44406.1 - 3.3e-32 110.9 0.0 7.7e-32 109.7 0.0 1.7 1 0 0 1 1 1 1 ABC1 family DUF947 PF06102.7 CCF44407.1 - 2.4e-26 92.5 25.2 2.7e-26 92.3 17.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF947) Sec10 PF07393.6 CCF44408.1 - 4.5e-125 418.5 2.8 4.5e-125 418.5 2.0 1.4 2 0 0 2 2 2 1 Exocyst complex component Sec10 KfrA_N PF11740.3 CCF44408.1 - 1 9.7 0.0 1 9.7 0.0 3.7 5 0 0 5 5 5 0 Plasmid replication region DNA-binding N-term BTB PF00651.26 CCF44409.1 - 0.11 12.5 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain Flavin_Reduct PF01613.13 CCF44411.1 - 1.1e-12 48.0 0.0 1.6e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain Pyridox_oxidase PF01243.15 CCF44411.1 - 0.0081 16.1 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Dmrt1 PF12374.3 CCF44412.1 - 0.037 14.3 1.3 0.082 13.2 0.9 1.5 1 0 0 1 1 1 0 Double-sex mab3 related transcription factor 1 p450 PF00067.17 CCF44413.1 - 0.00036 19.1 0.0 0.00039 19.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 UAA PF08449.6 CCF44414.1 - 1.9e-08 33.5 6.8 3e-08 32.9 4.7 1.4 1 1 0 1 1 1 1 UAA transporter family DUF2000 PF09391.5 CCF44414.1 - 0.13 11.9 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2000) SIR2 PF02146.12 CCF44415.1 - 8.3e-30 103.8 0.0 1.3e-29 103.2 0.0 1.3 1 0 0 1 1 1 1 Sir2 family Y1_Tnp PF01797.11 CCF44418.1 - 0.071 12.9 0.0 0.092 12.6 0.0 1.2 1 0 0 1 1 1 0 Transposase IS200 like GMC_oxred_C PF05199.8 CCF44419.1 - 2.7e-27 95.8 0.0 5.6e-27 94.7 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.14 CCF44419.1 - 4.7e-27 94.9 0.0 5e-25 88.2 0.0 2.5 2 1 0 2 2 2 1 GMC oxidoreductase Pyr_redox_2 PF07992.9 CCF44419.1 - 0.0027 17.6 0.0 0.0054 16.6 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF44419.1 - 0.0063 15.4 0.0 0.01 14.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 CCF44419.1 - 0.01 15.8 0.1 0.025 14.6 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF44419.1 - 0.011 15.8 0.0 2.8 7.9 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF44419.1 - 0.022 13.6 0.0 0.035 13.0 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein ThiF PF00899.16 CCF44419.1 - 0.071 12.9 0.1 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 ThiF family FAD_binding_3 PF01494.14 CCF44419.1 - 0.11 11.5 0.1 0.16 10.9 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.17 CCF44419.1 - 0.3 9.8 0.1 0.43 9.3 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Methyltransf_2 PF00891.13 CCF44421.1 - 2e-14 53.3 0.1 3e-14 52.8 0.1 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_18 PF12847.2 CCF44421.1 - 0.016 15.7 0.0 0.03 14.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MT0933_antitox PF14013.1 CCF44423.1 - 1e-05 25.4 3.6 2e-05 24.6 2.5 1.5 1 0 0 1 1 1 1 MT0933-like antitoxin protein p450 PF00067.17 CCF44424.1 - 8.2e-58 196.0 0.0 8.9e-58 195.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Conotoxin PF02950.12 CCF44426.1 - 0.014 16.1 2.1 0.021 15.5 1.4 1.4 1 0 0 1 1 1 0 Conotoxin Toxin_12 PF07740.7 CCF44426.1 - 0.041 14.3 1.4 0.041 14.3 1.0 1.5 2 0 0 2 2 2 0 Ion channel inhibitory toxin Kisspeptin PF15152.1 CCF44426.1 - 0.14 12.8 0.8 0.21 12.2 0.6 1.3 1 0 0 1 1 1 0 Kisspeptin Chon_Sulph_att PF06566.6 CCF44426.1 - 0.6 9.6 3.2 0.73 9.4 2.2 1.1 1 0 0 1 1 1 0 Chondroitin sulphate attachment domain ADH_zinc_N PF00107.21 CCF44427.1 - 8.9e-12 44.6 0.0 1.7e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF44427.1 - 2.6e-06 27.1 0.0 4.6e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 CCF44427.1 - 0.011 16.6 0.0 0.032 15.1 0.0 1.7 2 0 0 2 2 2 0 Zinc-binding dehydrogenase Brix PF04427.13 CCF44428.1 - 3.9e-18 65.8 0.0 5.1e-18 65.4 0.0 1.2 1 0 0 1 1 1 1 Brix domain DUF4431 PF14485.1 CCF44428.1 - 0.084 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4431) Peptidase_S41 PF03572.13 CCF44429.1 - 5.6e-05 22.6 0.0 0.00012 21.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase family S41 Polysacc_deac_1 PF01522.16 CCF44431.1 - 5.1e-27 93.9 0.0 9.7e-27 93.0 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase Nucleo_P87 PF07267.6 CCF44431.1 - 0.089 11.4 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF566 PF04484.7 CCF44431.1 - 2.2 7.7 8.3 3.4 7.0 5.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) HSP70 PF00012.15 CCF44432.1 - 8.1e-30 103.2 0.0 3.8e-20 71.3 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 CCF44432.1 - 2.2e-05 23.2 0.0 2.7e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 MreB/Mbl protein EBV-NA1 PF02905.9 CCF44432.1 - 0.062 12.7 0.0 0.099 12.1 0.0 1.2 1 0 0 1 1 1 0 Epstein Barr virus nuclear antigen-1, DNA-binding domain Aldo_ket_red PF00248.16 CCF44433.1 - 6.1e-67 225.4 0.1 6.9e-67 225.2 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF4131 PF13567.1 CCF44435.1 - 0.074 12.4 0.4 0.074 12.4 0.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) MgtE PF01769.11 CCF44435.1 - 0.54 10.5 11.3 2.7 8.2 1.4 2.3 1 1 1 2 2 2 0 Divalent cation transporter O-antigen_lig PF13425.1 CCF44435.1 - 4.9 7.1 9.0 8.4 6.3 1.0 2.2 1 1 1 2 2 2 0 O-antigen ligase like membrane protein GMC_oxred_N PF00732.14 CCF44436.1 - 8.3e-27 94.1 0.0 3.5e-17 62.5 0.0 3.3 3 0 0 3 3 3 3 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF44436.1 - 1.5e-25 90.2 0.0 2.5e-25 89.4 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.9 CCF44436.1 - 0.00047 20.1 0.0 0.0018 18.2 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF44436.1 - 0.00054 19.9 0.1 0.0018 18.2 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF44436.1 - 0.012 14.5 0.0 0.04 12.8 0.0 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.9 CCF44436.1 - 0.059 11.8 0.2 0.089 11.2 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein Lycopene_cycl PF05834.7 CCF44436.1 - 0.098 11.5 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_2 PF00890.19 CCF44436.1 - 0.13 11.0 0.5 0.21 10.3 0.4 1.3 1 0 0 1 1 1 0 FAD binding domain FAD_binding_3 PF01494.14 CCF44436.1 - 0.21 10.6 0.3 0.31 10.0 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain NmrA PF05368.8 CCF44437.1 - 2e-26 92.7 0.0 2.4e-26 92.4 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF44437.1 - 1.2e-08 35.1 0.1 2.1e-08 34.3 0.1 1.6 1 1 0 1 1 1 1 NADH(P)-binding Semialdhyde_dh PF01118.19 CCF44437.1 - 0.0025 18.0 0.1 0.0052 17.0 0.0 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 CCF44437.1 - 0.013 15.4 0.1 0.024 14.5 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.7 CCF44437.1 - 0.12 11.2 0.0 0.2 10.5 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein Dynamin_N PF00350.18 CCF44438.1 - 1.2e-16 60.9 0.0 5.2e-16 58.9 0.0 2.1 2 0 0 2 2 2 1 Dynamin family Dynamin_M PF01031.15 CCF44438.1 - 1.8e-08 33.5 0.0 6.1e-07 28.5 0.0 2.2 1 1 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.18 CCF44438.1 - 0.00017 21.4 0.0 0.0018 18.2 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.1 CCF44438.1 - 0.038 13.9 0.1 0.6 10.0 0.0 2.9 2 0 0 2 2 2 0 AAA domain FliX PF10768.4 CCF44438.1 - 0.065 13.4 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Class II flagellar assembly regulator Miro PF08477.8 CCF44438.1 - 0.079 13.4 0.1 0.38 11.2 0.0 2.2 3 0 0 3 3 3 0 Miro-like protein Transferase PF02458.10 CCF44439.1 - 1.9e-05 23.2 0.0 5.7e-05 21.7 0.0 1.7 2 1 0 2 2 2 1 Transferase family p450 PF00067.17 CCF44440.1 - 1.2e-21 76.8 0.0 2.6e-21 75.7 0.0 1.5 2 0 0 2 2 2 1 Cytochrome P450 HTH_7 PF02796.10 CCF44440.1 - 0.002 17.9 0.0 0.0051 16.6 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase KR PF08659.5 CCF44441.1 - 1.4e-52 178.0 0.1 7.7e-52 175.5 0.0 2.2 2 0 0 2 2 2 1 KR domain adh_short PF00106.20 CCF44441.1 - 3.1e-40 137.8 0.0 5.5e-39 133.7 0.0 2.3 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N PF00107.21 CCF44441.1 - 5.9e-20 71.1 0.1 1e-19 70.3 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF44441.1 - 3.6e-11 44.0 0.0 1.1e-10 42.5 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.20 CCF44441.1 - 0.00038 20.6 0.0 0.00094 19.4 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site YjeF_N PF03853.10 CCF44442.1 - 1.2e-38 132.4 0.1 1.8e-38 131.7 0.1 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.5 CCF44442.1 - 3.6e-10 40.2 2.0 3.6e-10 40.2 1.4 2.3 2 1 0 2 2 2 1 FDF domain PIF1 PF05970.9 CCF44443.1 - 7.1e-60 202.8 0.1 1.9e-46 158.7 0.0 2.2 1 1 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.1 CCF44443.1 - 7.2e-17 61.6 0.0 1.6e-16 60.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CCF44443.1 - 2.2e-07 31.0 0.0 1.2e-06 28.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CCF44443.1 - 1.3e-06 28.0 0.1 3.6e-06 26.6 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain UvrD_C_2 PF13538.1 CCF44443.1 - 2.1e-05 24.6 0.0 0.00017 21.7 0.0 2.4 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.9 CCF44443.1 - 0.00012 19.9 0.1 0.00039 18.3 0.0 1.7 2 0 0 2 2 2 1 Helicase AAA_16 PF13191.1 CCF44443.1 - 0.00026 21.0 0.0 0.00088 19.3 0.0 1.9 2 0 0 2 2 1 1 AAA ATPase domain AAA PF00004.24 CCF44443.1 - 0.0015 18.7 0.0 0.0038 17.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.22 CCF44443.1 - 0.0015 18.7 0.0 0.0054 17.0 0.0 1.9 1 0 0 1 1 1 1 ABC transporter AFG1_ATPase PF03969.11 CCF44443.1 - 0.005 15.6 0.2 0.011 14.5 0.0 1.6 2 0 0 2 2 2 1 AFG1-like ATPase PhoH PF02562.11 CCF44443.1 - 0.0056 15.9 1.8 0.0097 15.1 0.0 2.3 3 0 0 3 3 3 1 PhoH-like protein T2SE PF00437.15 CCF44443.1 - 0.0076 15.1 0.0 0.013 14.4 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein RNA_helicase PF00910.17 CCF44443.1 - 0.0095 16.1 0.0 0.03 14.4 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_11 PF13086.1 CCF44443.1 - 0.013 15.0 1.2 0.33 10.4 0.0 3.1 2 1 1 3 3 3 0 AAA domain NACHT PF05729.7 CCF44443.1 - 0.018 14.7 0.0 0.037 13.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain DUF2075 PF09848.4 CCF44443.1 - 0.02 13.8 0.0 0.06 12.3 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.1 CCF44443.1 - 0.025 14.4 0.0 0.1 12.4 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.1 CCF44443.1 - 0.025 13.9 0.6 0.061 12.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 CCF44443.1 - 0.042 13.3 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.9 CCF44443.1 - 0.043 13.5 0.1 0.38 10.4 0.1 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) MobB PF03205.9 CCF44443.1 - 0.048 13.3 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Viral_helicase1 PF01443.13 CCF44443.1 - 0.053 13.0 0.2 4 6.9 0.0 2.9 2 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Arch_ATPase PF01637.13 CCF44443.1 - 0.075 12.7 0.0 0.2 11.3 0.0 1.8 1 1 0 1 1 1 0 Archaeal ATPase DUF258 PF03193.11 CCF44443.1 - 0.083 12.0 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Adeno_IVa2 PF02456.10 CCF44443.1 - 0.12 10.9 0.0 0.25 9.9 0.0 1.4 1 0 0 1 1 1 0 Adenovirus IVa2 protein Hce2 PF14856.1 CCF44445.1 - 4.8e-10 39.2 0.2 9.1e-10 38.3 0.1 1.4 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor COesterase PF00135.23 CCF44446.1 - 1.7e-74 251.4 0.0 6.2e-74 249.6 0.0 1.8 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF44446.1 - 8.9e-07 28.6 0.1 2.8e-06 27.0 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF44446.1 - 0.0024 17.1 0.3 0.0045 16.2 0.2 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CCF44446.1 - 0.03 14.0 0.1 0.067 12.9 0.1 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family CH PF00307.26 CCF44447.1 - 5e-10 39.3 0.0 8.3e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain DUF1720 PF08226.6 CCF44447.1 - 0.8 9.8 7.9 1.6 8.8 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1720) NDUFA12 PF05071.11 CCF44448.1 - 2.3e-10 40.8 0.2 2.3e-10 40.8 0.1 2.1 1 1 1 2 2 2 1 NADH ubiquinone oxidoreductase subunit NDUFA12 cwf21 PF08312.7 CCF44449.1 - 4.9e-18 64.6 13.5 1.4e-17 63.2 9.4 1.8 1 0 0 1 1 1 1 cwf21 domain GvpG PF05120.7 CCF44449.1 - 4.8 7.0 10.3 6.9 6.5 0.4 2.3 1 1 1 2 2 2 0 Gas vesicle protein G D123 PF07065.9 CCF44450.1 - 1.5e-85 286.8 0.0 2.2e-85 286.3 0.0 1.2 1 0 0 1 1 1 1 D123 DUF3716 PF12511.3 CCF44451.1 - 1.3e-15 56.7 9.8 2e-15 56.1 6.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) Tfb2 PF03849.9 CCF44454.1 - 7.5e-13 47.8 0.2 1.1e-12 47.3 0.1 1.2 1 0 0 1 1 1 1 Transcription factor Tfb2 Helicase_C_3 PF13625.1 CCF44454.1 - 1.5e-06 27.9 0.1 2.5e-05 24.0 0.1 2.3 1 1 0 1 1 1 1 Helicase conserved C-terminal domain SinI PF08671.5 CCF44454.1 - 0.0053 16.1 0.1 0.71 9.3 0.0 2.3 2 0 0 2 2 2 2 Anti-repressor SinI DUF3665 PF12427.3 CCF44455.1 - 0.82 9.0 3.3 1.9 7.9 2.3 1.6 1 0 0 1 1 1 0 Branched-chain amino acid aminotransferase DHC_N1 PF08385.7 CCF44456.1 - 3.7e-61 207.2 13.0 7.1e-61 206.2 0.1 3.8 2 1 2 4 4 4 2 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 CCF44456.1 - 5.1e-23 81.2 0.4 5.1e-23 81.2 0.2 4.6 3 1 0 4 4 4 3 Dynein heavy chain, N-terminal region 2 HrpB7 PF09486.5 CCF44456.1 - 0.71 9.7 8.3 0.58 10.0 0.1 3.7 4 1 0 4 4 4 0 Bacterial type III secretion protein (HrpB7) DUF1664 PF07889.7 CCF44456.1 - 1 9.1 10.1 1.7 8.4 0.4 4.9 4 2 2 6 6 6 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.7 CCF44456.1 - 6.8 7.0 10.1 31 4.9 0.1 5.4 4 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein FAD_binding_3 PF01494.14 CCF44457.1 - 8e-13 48.1 0.0 1.2e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain SE PF08491.5 CCF44457.1 - 0.0088 14.9 0.0 0.02 13.7 0.0 1.5 1 0 0 1 1 1 1 Squalene epoxidase Clr5 PF14420.1 CCF44458.1 - 0.00013 21.7 0.4 0.00031 20.5 0.3 1.7 1 0 0 1 1 1 1 Clr5 domain TPR_7 PF13176.1 CCF44458.1 - 0.0077 15.9 0.8 21 5.2 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 CCF44458.1 - 0.019 14.8 6.9 0.14 12.1 0.3 3.2 1 1 3 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 CCF44458.1 - 0.056 13.0 1.0 1.1 8.9 0.2 2.6 2 0 0 2 2 2 0 TPR repeat TPR_2 PF07719.12 CCF44458.1 - 0.089 12.7 0.1 18 5.5 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 CCF44458.1 - 0.13 11.8 0.2 24 4.7 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat p450 PF00067.17 CCF44459.1 - 3.7e-92 309.2 0.0 4.3e-92 309.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 AAL_decarboxy PF03306.8 CCF44460.1 - 1.6e-69 233.3 0.0 1.8e-69 233.1 0.0 1.0 1 0 0 1 1 1 1 Alpha-acetolactate decarboxylase MFS_1 PF07690.11 CCF44463.1 - 5.7e-31 107.4 32.1 8.8e-31 106.8 22.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily NAAA-beta PF15508.1 CCF44465.1 - 5.2e-20 71.6 0.0 8.4e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase p450 PF00067.17 CCF44466.1 - 7.5e-55 186.2 0.0 1.3e-54 185.5 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Iso_dh PF00180.15 CCF44467.1 - 9.6e-82 274.7 0.0 1.1e-81 274.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase MFS_1 PF07690.11 CCF44469.1 - 2.7e-12 46.0 26.4 3.1e-12 45.8 18.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily VIT1 PF01988.14 CCF44469.1 - 4 6.8 8.9 0.34 10.3 2.5 1.7 1 1 1 2 2 2 0 VIT family FAM70 PF14967.1 CCF44470.1 - 0.12 11.5 0.1 0.12 11.5 0.1 1.0 1 0 0 1 1 1 0 FAM70 protein TPR_16 PF13432.1 CCF44472.1 - 0.00028 21.4 2.5 1.6 9.4 0.1 4.3 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 CCF44472.1 - 0.0011 18.7 0.7 19 5.4 0.1 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.1 CCF44472.1 - 0.029 14.3 3.7 0.58 10.1 0.0 3.9 4 1 0 4 4 4 0 Tetratricopeptide repeat Mucin PF01456.12 CCF44472.1 - 6 6.6 12.7 14 5.4 8.8 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein TPP_enzyme_N PF02776.13 CCF44473.1 - 7.5e-31 106.9 5.7 4.8e-29 101.0 2.1 2.6 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 CCF44473.1 - 5.5e-23 81.2 0.1 9e-23 80.5 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain PDR_CDR PF06422.7 CCF44474.1 - 0.045 13.4 0.5 0.058 13.0 0.3 1.5 1 1 0 1 1 1 0 CDR ABC transporter Leader_CPA1 PF08252.6 CCF44474.1 - 0.095 11.9 0.7 4.2 6.7 0.0 2.4 2 0 0 2 2 2 0 arg-2/CPA1 leader peptide DUF2024 PF09630.5 CCF44474.1 - 0.12 12.0 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2024) MoCF_biosynth PF00994.19 CCF44475.1 - 2.9e-33 114.3 0.0 1.2e-32 112.2 0.0 1.9 2 0 0 2 2 2 1 Probable molybdopterin binding domain MoeA_N PF03453.12 CCF44475.1 - 2.5e-27 95.2 0.4 4e-27 94.5 0.2 1.4 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) TPT PF03151.11 CCF44476.1 - 6.1e-28 97.3 13.8 6.1e-28 97.3 9.6 2.5 2 1 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 CCF44476.1 - 0.00071 18.5 25.7 0.019 13.8 17.8 2.1 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 CCF44476.1 - 0.0013 18.7 32.3 0.025 14.6 8.2 2.6 3 0 0 3 3 3 2 EamA-like transporter family Mito_carr PF00153.22 CCF44477.1 - 1.8e-54 181.4 0.2 1.6e-18 66.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Peptidase_C2 PF00648.16 CCF44479.1 - 6.1e-22 77.9 0.0 1e-21 77.2 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.17 CCF44479.1 - 2.1e-15 56.6 0.0 2.2e-12 46.8 0.0 2.9 2 1 0 2 2 2 2 Calpain large subunit, domain III MIT PF04212.13 CCF44479.1 - 0.00092 19.0 0.1 0.0017 18.1 0.1 1.3 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain zf-C2H2_4 PF13894.1 CCF44480.1 - 3.3e-07 30.1 11.6 0.00065 19.8 1.9 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF44480.1 - 1.6e-05 24.9 11.4 0.0051 17.0 1.2 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CCF44480.1 - 0.00092 19.3 8.6 0.77 10.1 0.2 3.5 3 0 0 3 3 3 3 Zinc-finger double domain zf-Di19 PF05605.7 CCF44480.1 - 2.3 8.3 5.4 0.34 11.0 0.6 1.9 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Cupin_2 PF07883.6 CCF44481.1 - 1.2e-07 31.1 0.1 2.1e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.7 CCF44481.1 - 0.076 12.4 0.1 0.13 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Peptidase_M22 PF00814.20 CCF44482.1 - 9.8e-85 284.2 0.0 1.2e-84 284.0 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family BcrAD_BadFG PF01869.15 CCF44482.1 - 0.09 12.0 0.0 0.37 10.0 0.0 1.8 1 1 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family AMPKBI PF04739.10 CCF44483.1 - 3.1e-30 104.0 1.5 5.3e-30 103.2 1.0 1.3 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interation domain TF_Zn_Ribbon PF08271.7 CCF44484.1 - 0.058 12.7 0.0 0.086 12.1 0.0 1.2 1 0 0 1 1 1 0 TFIIB zinc-binding DUF1936 PF09151.5 CCF44484.1 - 0.13 11.7 1.4 0.25 10.8 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1936) Mito_fiss_reg PF05308.6 CCF44484.1 - 0.37 10.1 8.2 1.3 8.3 0.1 2.1 1 1 1 2 2 2 0 Mitochondrial fission regulator FGGY_C PF02782.11 CCF44486.1 - 3.3e-72 242.2 0.8 5.7e-72 241.5 0.5 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 CCF44486.1 - 1e-66 224.7 0.0 1.3e-66 224.4 0.0 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.15 CCF44486.1 - 0.026 13.8 0.2 0.32 10.2 0.0 2.1 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family HTH_IclR PF09339.5 CCF44486.1 - 0.032 13.8 0.1 0.23 11.0 0.0 2.3 2 0 0 2 2 2 0 IclR helix-turn-helix domain WAPL PF07814.8 CCF44487.1 - 1.7e-11 43.4 0.0 4.9e-10 38.6 0.0 2.1 2 0 0 2 2 2 2 Wings apart-like protein regulation of heterochromatin Fun_ATP-synt_8 PF05933.8 CCF44487.1 - 0.099 12.6 0.2 0.19 11.7 0.2 1.4 1 0 0 1 1 1 0 Fungal ATP synthase protein 8 (A6L) UPRTase PF14681.1 CCF44488.1 - 1.1e-80 269.7 0.0 1.3e-80 269.4 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 CCF44488.1 - 0.00023 20.8 0.0 0.00033 20.3 0.0 1.4 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Flu_C_NS1 PF03506.8 CCF44488.1 - 0.14 11.8 0.2 0.23 11.2 0.1 1.2 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) Elf1 PF05129.8 CCF44489.1 - 2.3e-28 97.7 0.2 2.9e-28 97.3 0.1 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like GTP_CH_N PF12471.3 CCF44490.1 - 9.5e-87 289.6 0.0 1.3e-86 289.2 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.15 CCF44490.1 - 8.5e-17 60.9 0.0 1.3e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II FMN_dh PF01070.13 CCF44493.1 - 1.3e-69 234.7 4.4 1.5e-69 234.6 3.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.10 CCF44493.1 - 1.5e-09 37.4 0.3 1.7e-09 37.2 0.2 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 CCF44493.1 - 1.1e-08 34.4 2.0 4e-08 32.5 0.4 2.2 2 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.9 CCF44493.1 - 1.3e-06 27.7 0.2 0.001 18.2 0.1 2.2 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.12 CCF44493.1 - 3e-06 26.3 0.8 5.8e-06 25.4 0.5 1.6 1 1 0 1 1 1 1 Conserved region in glutamate synthase DHO_dh PF01180.16 CCF44493.1 - 5.2e-06 25.6 0.4 8.1e-05 21.7 0.0 2.0 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase His_biosynth PF00977.16 CCF44493.1 - 5.2e-06 25.8 0.3 0.0022 17.3 0.0 2.3 1 1 1 2 2 2 2 Histidine biosynthesis protein PcrB PF01884.12 CCF44493.1 - 0.00034 19.9 1.4 0.22 10.7 0.1 2.1 1 1 1 2 2 2 2 PcrB family Dus PF01207.12 CCF44493.1 - 0.0031 16.4 0.1 0.005 15.7 0.1 1.4 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) IGPS PF00218.16 CCF44493.1 - 0.028 13.4 0.1 0.84 8.6 0.1 2.1 1 1 1 2 2 2 0 Indole-3-glycerol phosphate synthase Ribul_P_3_epim PF00834.14 CCF44493.1 - 0.061 12.4 0.6 4.7 6.2 0.0 2.2 1 1 1 2 2 2 0 Ribulose-phosphate 3 epimerase family G3P_antiterm PF04309.7 CCF44493.1 - 0.068 12.2 0.3 5 6.1 0.0 2.2 1 1 1 2 2 2 0 Glycerol-3-phosphate responsive antiterminator TMP-TENI PF02581.12 CCF44493.1 - 0.077 12.1 0.1 6.3 5.8 0.0 2.2 2 0 0 2 2 2 0 Thiamine monophosphate synthase/TENI BtpA PF03437.10 CCF44493.1 - 0.11 11.7 0.0 0.21 10.7 0.0 1.5 2 0 0 2 2 2 0 BtpA family MFS_1 PF07690.11 CCF44494.1 - 1.9e-32 112.3 34.6 2.2e-32 112.1 24.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1228 PF06779.9 CCF44494.1 - 0.064 13.2 0.6 0.064 13.2 0.4 3.5 2 2 1 3 3 3 0 Protein of unknown function (DUF1228) Sugar_tr PF00083.19 CCF44494.1 - 0.26 9.8 30.6 1.3 7.4 21.5 2.0 1 1 0 1 1 1 0 Sugar (and other) transporter Transgly_assoc PF04226.8 CCF44494.1 - 0.78 9.8 7.4 13 5.9 1.4 3.8 3 0 0 3 3 3 0 Transglycosylase associated protein DUF3210 PF11489.3 CCF44496.1 - 1.3e-116 391.0 54.1 1.3e-116 391.0 37.5 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3210) NA37 PF04245.8 CCF44496.1 - 0.07 12.4 1.4 0.14 11.5 1.0 1.4 1 0 0 1 1 1 0 37-kD nucleoid-associated bacterial protein Glyco_hydro_10 PF00331.15 CCF44497.1 - 2.8e-87 292.7 0.0 3.3e-87 292.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Tub PF01167.13 CCF44497.1 - 0.14 11.1 0.2 0.2 10.6 0.2 1.2 1 0 0 1 1 1 0 Tub family POT1 PF02765.12 CCF44498.1 - 7.1e-06 25.9 0.0 8e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 UPF0220 PF05255.6 CCF44498.1 - 0.054 12.7 0.0 0.076 12.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0220) SIR2 PF02146.12 CCF44499.1 - 3.4e-24 85.5 0.0 8.6e-24 84.2 0.0 1.7 1 1 0 1 1 1 1 Sir2 family SNF2_N PF00176.18 CCF44500.1 - 1e-62 211.6 0.1 1.9e-62 210.7 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.19 CCF44500.1 - 5.1e-25 86.9 5.2 3.6e-14 52.1 0.4 3.0 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.26 CCF44500.1 - 9.8e-15 54.1 0.0 2.8e-14 52.7 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF44500.1 - 2.7e-05 24.0 0.0 0.00028 20.7 0.0 2.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 CCF44500.1 - 0.012 15.7 0.0 0.041 14.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.20 CCF44501.1 - 1.2e-34 119.6 0.0 3.7e-34 118.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF44501.1 - 7.1e-18 64.6 0.0 7.5e-10 38.3 0.0 3.1 3 0 0 3 3 3 3 Protein tyrosine kinase GST_C_2 PF13410.1 CCF44503.1 - 0.011 15.5 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Chitin_synth_2 PF03142.10 CCF44504.1 - 3.5e-183 609.8 8.1 9.4e-183 608.3 6.1 1.3 2 0 0 2 2 2 1 Chitin synthase DEK_C PF08766.6 CCF44504.1 - 3.8e-19 68.2 0.2 6.6e-18 64.2 0.2 2.3 2 0 0 2 2 2 1 DEK C terminal domain Glyco_trans_2_3 PF13632.1 CCF44504.1 - 5.6e-15 55.5 9.8 1.7e-14 53.9 6.8 1.8 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 CCF44504.1 - 9.2e-13 48.5 0.1 2.4e-12 47.1 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 CCF44504.1 - 4.6e-05 23.1 0.0 0.0001 22.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 CCF44504.1 - 0.0023 17.2 0.6 0.025 13.8 0.4 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 21 RTA1 PF04479.8 CCF44505.1 - 5.6e-51 173.1 7.8 7.3e-51 172.8 5.4 1.0 1 0 0 1 1 1 1 RTA1 like protein DUF2975 PF11188.3 CCF44505.1 - 5.3 6.7 13.0 0.19 11.4 2.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2975) Peptidase_MA_2 PF13485.1 CCF44507.1 - 0.003 17.5 1.1 0.0057 16.6 0.7 1.5 1 0 0 1 1 1 1 Peptidase MA superfamily zf-CCHC PF00098.18 CCF44509.1 - 1.3e-11 43.8 9.7 1.8e-05 24.4 0.4 2.4 2 0 0 2 2 2 2 Zinc knuckle KH_1 PF00013.24 CCF44509.1 - 3.1e-08 33.1 0.3 5.5e-08 32.3 0.2 1.4 1 0 0 1 1 1 1 KH domain zf-CCHC_3 PF13917.1 CCF44509.1 - 8.7e-07 28.5 6.0 0.00031 20.3 2.1 2.5 1 1 1 2 2 2 2 Zinc knuckle KH_3 PF13014.1 CCF44509.1 - 4.7e-05 22.9 0.2 0.00011 21.7 0.2 1.6 1 0 0 1 1 1 1 KH domain zf-CCHC_6 PF15288.1 CCF44509.1 - 0.00041 19.9 7.1 0.1 12.3 0.2 2.7 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.1 CCF44509.1 - 0.0011 18.5 6.0 0.28 10.8 0.5 2.4 2 0 0 2 2 2 2 Zinc knuckle Peptidase_M16_C PF05193.16 CCF44509.1 - 0.36 10.4 3.3 6.7 6.3 0.1 2.6 2 1 0 2 2 2 0 Peptidase M16 inactive domain MFS_1 PF07690.11 CCF44510.1 - 8.5e-19 67.4 12.3 1.1e-18 67.1 8.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily CENP-B_N PF04218.8 CCF44510.1 - 0.0011 18.3 0.0 0.0021 17.4 0.0 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain Troponin-I_N PF11636.3 CCF44511.1 - 0.011 15.3 1.2 0.04 13.6 0.9 1.9 1 0 0 1 1 1 0 Troponin I residues 1-32 Pro_isomerase PF00160.16 CCF44512.1 - 2.6e-35 121.9 0.1 6.4e-35 120.6 0.1 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Fungal_trans_2 PF11951.3 CCF44513.1 - 5.5e-46 156.9 0.0 6.9e-46 156.5 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sin3_corepress PF08295.7 CCF44513.1 - 0.033 13.9 0.2 0.087 12.5 0.0 1.7 2 0 0 2 2 2 0 Sin3 family co-repressor Ferritin_2 PF13668.1 CCF44514.1 - 1.2e-41 141.8 0.7 1.9e-41 141.2 0.5 1.3 1 0 0 1 1 1 1 Ferritin-like domain FMN_dh PF01070.13 CCF44515.1 - 1.9e-121 405.2 0.0 2.2e-121 405.0 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.12 CCF44515.1 - 2.6e-05 23.3 0.3 3.7e-05 22.8 0.2 1.1 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.20 CCF44515.1 - 0.00018 20.5 0.5 0.00058 18.8 0.3 1.7 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.9 CCF44515.1 - 0.0026 16.8 0.5 0.061 12.3 0.4 2.2 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG NMO PF03060.10 CCF44515.1 - 0.0045 16.1 1.7 0.007 15.5 1.2 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.16 CCF44515.1 - 0.0071 15.6 0.2 0.027 13.7 0.0 1.9 1 1 0 2 2 2 1 Histidine biosynthesis protein Sld5 PF05916.6 CCF44516.1 - 4.5e-08 33.3 0.2 6.9e-08 32.7 0.2 1.3 1 0 0 1 1 1 1 GINS complex protein Sugar_tr PF00083.19 CCF44518.1 - 3.3e-24 85.2 9.1 3.7e-24 85.1 6.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF44518.1 - 3.5e-12 45.6 10.6 4.2e-12 45.4 7.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF44518.1 - 0.00018 20.0 1.8 0.00019 20.0 1.3 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein TRI12 PF06609.8 CCF44518.1 - 0.03 12.5 2.2 0.032 12.4 1.5 1.1 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) Acyl_transf_3 PF01757.17 CCF44518.1 - 0.1 11.3 7.1 0.17 10.7 4.9 1.3 1 1 0 1 1 1 0 Acyltransferase family Phage_holin_2 PF04550.7 CCF44518.1 - 0.46 10.6 4.5 0.65 10.1 2.7 1.7 1 1 0 1 1 1 0 Phage holin family 2 p450 PF00067.17 CCF44519.1 - 8.8e-18 64.0 0.0 3.8e-17 61.9 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 RTC PF01137.16 CCF44521.1 - 5.8e-37 126.6 0.0 9.5e-36 122.6 0.0 2.1 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase DUF2561 PF10812.3 CCF44522.1 - 0.015 14.8 0.4 0.041 13.4 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2561) Sulfate_transp PF00916.15 CCF44522.1 - 0.05 12.5 0.2 0.069 12.1 0.1 1.1 1 0 0 1 1 1 0 Sulfate transporter family Pho88 PF10032.4 CCF44523.1 - 2.8e-71 238.7 0.0 3.1e-71 238.5 0.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) XPA_C PF05181.7 CCF44524.1 - 2.9e-28 97.2 4.8 4.3e-28 96.6 2.4 2.0 2 0 0 2 2 2 1 XPA protein C-terminus XPA_N PF01286.13 CCF44524.1 - 7.3e-05 22.3 1.6 0.00012 21.6 1.1 1.4 1 0 0 1 1 1 1 XPA protein N-terminal ArfGap PF01412.13 CCF44524.1 - 0.0078 15.9 0.4 0.015 15.0 0.3 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf XFP_C PF09363.5 CCF44525.1 - 7.3e-68 228.0 0.0 9.7e-68 227.5 0.0 1.1 1 0 0 1 1 1 1 XFP C-terminal domain XFP PF03894.10 CCF44525.1 - 2.5e-31 108.6 0.1 3.7e-31 108.1 0.1 1.3 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase Sipho_Gp157 PF05565.6 CCF44525.1 - 0.037 13.6 0.2 0.062 12.8 0.1 1.3 1 0 0 1 1 1 0 Siphovirus Gp157 Transketolase_C PF02780.15 CCF44525.1 - 0.075 12.9 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 Transketolase, C-terminal domain Pinin_SDK_N PF04697.8 CCF44526.1 - 0.15 12.1 0.5 0.16 12.0 0.3 1.1 1 0 0 1 1 1 0 pinin/SDK conserved region RabGAP-TBC PF00566.13 CCF44527.1 - 1.6e-44 151.9 1.5 2.7e-44 151.1 0.0 2.0 2 0 0 2 2 2 1 Rab-GTPase-TBC domain zf-C4H2 PF10146.4 CCF44527.1 - 3.8e-06 27.0 1.9 3.8e-06 27.0 1.3 2.2 2 0 0 2 2 2 1 Zinc finger-containing protein Myosin_tail_1 PF01576.14 CCF44527.1 - 0.0012 16.6 7.3 0.0012 16.6 5.1 2.6 3 0 0 3 3 3 2 Myosin tail IncA PF04156.9 CCF44527.1 - 0.0023 17.5 27.4 0.03 13.9 8.3 3.3 3 0 0 3 3 3 2 IncA protein DUF869 PF05911.6 CCF44527.1 - 0.014 13.6 17.0 0.027 12.7 0.3 2.7 3 0 0 3 3 3 0 Plant protein of unknown function (DUF869) DUF342 PF03961.8 CCF44527.1 - 0.14 10.5 8.5 0.11 10.8 1.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF342) Mnd1 PF03962.10 CCF44527.1 - 0.26 10.9 24.7 0.4 10.3 2.1 3.1 3 0 0 3 3 3 0 Mnd1 family APG6 PF04111.7 CCF44527.1 - 0.37 9.7 21.8 0.28 10.1 4.7 3.1 3 0 0 3 3 3 0 Autophagy protein Apg6 Fib_alpha PF08702.5 CCF44527.1 - 0.51 10.4 10.3 0.58 10.2 2.1 2.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family ADIP PF11559.3 CCF44527.1 - 1.2 9.0 27.7 0.083 12.7 5.1 3.3 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding V_ATPase_I PF01496.14 CCF44527.1 - 1.8 6.3 8.9 0.24 9.1 1.1 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Ax_dynein_light PF10211.4 CCF44527.1 - 4.7 6.9 19.8 0.58 9.9 0.6 2.9 3 0 0 3 3 3 0 Axonemal dynein light chain EMP24_GP25L PF01105.19 CCF44527.1 - 5.5 6.6 14.6 4.3 7.0 0.5 2.8 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF1664 PF07889.7 CCF44527.1 - 7.5 6.3 10.6 3.5 7.4 2.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Aminotran_1_2 PF00155.16 CCF44528.1 - 5.4e-37 127.5 0.0 6.4e-37 127.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 CCF44528.1 - 0.0039 15.5 0.0 0.0071 14.6 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Mannosyl_trans3 PF11051.3 CCF44529.1 - 5e-34 117.8 0.1 2.1e-33 115.8 0.0 1.8 1 1 0 1 1 1 1 Mannosyltransferase putative AMP-binding PF00501.23 CCF44530.1 - 2.8e-70 236.8 0.0 3.3e-70 236.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF44530.1 - 1.1e-07 32.6 0.0 2.1e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Response_reg PF00072.19 CCF44531.1 - 6.5e-09 35.7 0.0 7.6e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain AA_permease_2 PF13520.1 CCF44532.1 - 6.6e-53 179.7 49.4 8.3e-53 179.4 34.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF44532.1 - 3.5e-25 88.2 45.1 5e-25 87.7 31.2 1.1 1 0 0 1 1 1 1 Amino acid permease Cation_efflux PF01545.16 CCF44534.1 - 9.5e-13 47.8 15.2 1.8e-11 43.6 4.5 2.9 2 1 0 2 2 2 2 Cation efflux family P33MONOX PF15302.1 CCF44535.1 - 0.045 13.3 2.0 0.092 12.3 0.3 1.9 1 1 1 2 2 2 0 P33 mono-oxygenase DUF3622 PF12286.3 CCF44535.1 - 1.3 9.3 6.8 2.8 8.3 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3622) DNase_NucA_NucB PF14040.1 CCF44536.1 - 0.0017 18.4 0.0 0.0041 17.2 0.0 1.7 1 0 0 1 1 1 1 Deoxyribonuclease NucA/NucB Glyco_hydro_18 PF00704.23 CCF44537.1 - 6.4e-25 88.3 0.1 8.4e-25 87.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 SUR7 PF06687.7 CCF44538.1 - 5.9e-30 104.4 8.9 7.2e-30 104.1 6.2 1.1 1 0 0 1 1 1 1 SUR7/PalI family NfeD PF01957.13 CCF44538.1 - 0.023 14.8 1.1 0.023 14.8 0.8 2.4 2 1 1 3 3 3 0 NfeD-like C-terminal, partner-binding HsbA PF12296.3 CCF44539.1 - 5e-08 32.8 5.3 9.4e-08 31.9 3.7 1.5 1 0 0 1 1 1 1 Hydrophobic surface binding protein A DUF3486 PF11985.3 CCF44539.1 - 0.53 10.3 6.1 1.7 8.6 4.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3486) Gly-zipper_Omp PF13488.1 CCF44541.1 - 0.29 10.7 3.6 0.65 9.6 2.5 1.5 1 0 0 1 1 1 0 Glycine zipper adh_short PF00106.20 CCF44542.1 - 4.9e-30 104.6 0.6 6.5e-30 104.2 0.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF44542.1 - 1.3e-25 90.5 0.0 1.7e-25 90.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF44542.1 - 3.2e-17 62.7 0.1 4.7e-17 62.2 0.1 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF44542.1 - 0.086 12.8 0.1 0.18 11.8 0.0 1.6 1 1 0 1 1 1 0 NADH(P)-binding DUF4070 PF13282.1 CCF44543.1 - 0.045 13.2 0.2 0.77 9.3 0.0 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4070) Dabb PF07876.7 CCF44545.1 - 4.1e-10 39.9 0.0 4.9e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain DUF2701 PF10857.3 CCF44545.1 - 0.13 12.0 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2701) Lactamase_B PF00753.22 CCF44546.1 - 4.5e-19 68.8 0.1 9.6e-19 67.7 0.1 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CCF44546.1 - 3e-05 23.6 0.0 4.4e-05 23.1 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 CCF44546.1 - 0.00054 19.7 0.0 0.00082 19.1 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain UCH PF00443.24 CCF44547.1 - 2.3e-56 190.8 0.9 3.4e-56 190.3 0.6 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CCF44547.1 - 8.9e-33 113.9 0.3 1.4e-32 113.3 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 CCF44547.1 - 2e-05 24.6 0.4 2e-05 24.6 0.3 2.4 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein zf-ribbon_3 PF13248.1 CCF44547.1 - 0.11 11.7 2.2 25 4.2 0.1 3.6 3 1 0 3 3 3 0 zinc-ribbon domain zf-CCHC PF00098.18 CCF44547.1 - 4.2 7.4 8.5 60 3.8 0.0 4.3 4 0 0 4 4 4 0 Zinc knuckle N6-adenineMlase PF10237.4 CCF44548.1 - 7e-52 175.3 0.0 8.7e-52 175.0 0.0 1.1 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase NAD_binding_10 PF13460.1 CCF44549.1 - 2.9e-18 66.5 0.0 4.1e-18 66.0 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF44549.1 - 3.3e-16 59.2 0.0 4.2e-16 58.9 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.16 CCF44549.1 - 6e-15 55.3 0.2 1.1e-14 54.4 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF44549.1 - 1.1e-11 44.0 0.1 2.7e-11 42.6 0.1 1.6 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 CCF44549.1 - 3.5e-10 39.2 0.0 2.4e-08 33.2 0.0 2.4 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 CCF44549.1 - 0.00037 19.5 0.7 0.052 12.4 0.3 3.0 1 1 1 2 2 2 1 Male sterility protein KR PF08659.5 CCF44549.1 - 0.00038 20.1 0.0 0.71 9.5 0.0 2.2 2 0 0 2 2 2 2 KR domain adh_short PF00106.20 CCF44549.1 - 0.00057 19.8 0.0 0.0054 16.6 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase Saccharop_dh PF03435.13 CCF44549.1 - 0.0013 17.8 0.0 0.0019 17.2 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Polysacc_synt_2 PF02719.10 CCF44549.1 - 0.007 15.2 0.0 0.011 14.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_synthase PF02540.12 CCF44549.1 - 0.041 12.7 0.0 0.069 12.0 0.0 1.3 1 0 0 1 1 1 0 NAD synthase 2-Hacid_dh_C PF02826.14 CCF44549.1 - 0.095 11.8 0.2 0.78 8.8 0.1 2.1 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DDE_Tnp_1_3 PF13612.1 CCF44549.1 - 0.1 12.3 0.0 0.37 10.5 0.0 1.8 2 0 0 2 2 2 0 Transposase DDE domain ApbA PF02558.11 CCF44549.1 - 0.11 11.9 0.0 0.26 10.7 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA PCI PF01399.22 CCF44550.1 - 7.9e-11 42.2 0.0 1.6e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 PCI domain Spo0A_C PF08769.6 CCF44550.1 - 0.017 15.0 0.0 0.039 13.8 0.0 1.6 1 0 0 1 1 1 0 Sporulation initiation factor Spo0A C terminal Gaa1 PF04114.9 CCF44551.1 - 0.00091 18.0 1.2 0.0013 17.5 0.8 1.2 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component FAD_binding_4 PF01565.18 CCF44552.1 - 5.7e-14 51.7 2.0 5.7e-14 51.7 1.4 1.7 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.7 CCF44552.1 - 2.5e-10 40.0 0.0 4.8e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like D5_N PF08706.6 CCF44557.1 - 0.044 13.8 1.6 0.12 12.4 1.1 1.7 2 0 0 2 2 2 0 D5 N terminal like DUF2461 PF09365.5 CCF44557.1 - 0.23 10.8 0.0 0.23 10.8 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical protein (DUF2461) zinc_ribbon_6 PF14599.1 CCF44558.1 - 0.069 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Zinc-ribbon TAFH PF07531.9 CCF44558.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 NHR1 homology to TAF DUF1533 PF07550.6 CCF44559.1 - 0.081 12.9 0.1 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1533) MFS_1 PF07690.11 CCF44560.1 - 0.023 13.4 11.1 0.14 10.8 7.7 2.0 1 1 0 1 1 1 0 Major Facilitator Superfamily Thiolase_N PF00108.18 CCF44562.1 - 5.7e-73 245.1 0.8 7.7e-73 244.7 0.6 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 CCF44562.1 - 4.6e-39 132.6 0.8 4.6e-39 132.6 0.5 1.8 2 0 0 2 2 2 1 Thiolase, C-terminal domain UxuA PF03786.8 CCF44563.1 - 0.071 11.6 0.0 0.088 11.3 0.0 1.2 1 0 0 1 1 1 0 D-mannonate dehydratase (UxuA) Ank_2 PF12796.2 CCF44564.1 - 3.5e-46 155.4 8.2 4.2e-16 59.0 0.0 5.0 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 CCF44564.1 - 1e-28 97.6 12.6 5.9e-08 32.1 0.0 7.3 7 1 0 7 7 7 5 Ankyrin repeat Ank_4 PF13637.1 CCF44564.1 - 2.2e-27 94.9 2.8 7.7e-10 39.0 0.0 5.1 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF44564.1 - 7e-25 86.4 9.9 1.7e-10 40.7 0.0 6.2 2 2 4 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF44564.1 - 9e-24 81.1 1.4 1e-05 25.2 0.0 7.8 7 1 1 8 8 8 4 Ankyrin repeat NUDIX PF00293.23 CCF44565.1 - 0.0084 15.7 0.0 0.032 13.8 0.0 2.0 1 1 0 1 1 1 1 NUDIX domain Med19 PF10278.4 CCF44566.1 - 0.11 12.1 5.2 0.17 11.5 3.6 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 SR-25 PF10500.4 CCF44566.1 - 0.15 11.4 9.6 0.21 11.0 6.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.6 CCF44566.1 - 4.1 7.4 16.2 7.5 6.6 11.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Pkinase PF00069.20 CCF44568.1 - 3.9e-15 55.6 0.0 6e-15 55.0 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF44568.1 - 2.7e-09 36.4 0.0 4.1e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF44568.1 - 4.4e-06 25.8 0.0 6.1e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CCF44568.1 - 0.00054 19.7 0.2 0.00072 19.3 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 CCF44568.1 - 0.029 13.4 0.0 0.041 12.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family VWA_2 PF13519.1 CCF44569.1 - 0.0026 17.9 0.1 0.0049 16.9 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain FAD_binding_3 PF01494.14 CCF44570.1 - 1.6e-21 76.7 0.0 3.7e-21 75.5 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF44570.1 - 1e-11 44.3 1.8 6.3e-08 31.9 1.3 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF44570.1 - 3.5e-08 33.3 0.6 6.8e-08 32.4 0.4 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CCF44570.1 - 2.2e-06 26.8 3.2 2.2e-06 26.8 2.2 2.2 3 0 0 3 3 3 1 FAD binding domain Amino_oxidase PF01593.19 CCF44570.1 - 3.6e-06 26.3 0.8 0.05 12.6 0.2 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Trp_halogenase PF04820.9 CCF44570.1 - 3.6e-06 25.8 0.6 0.0024 16.5 0.3 2.2 2 0 0 2 2 2 2 Tryptophan halogenase Pyr_redox PF00070.22 CCF44570.1 - 1.1e-05 25.7 1.0 0.00069 19.9 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CCF44570.1 - 4.2e-05 23.5 1.0 0.0001 22.2 0.7 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF44570.1 - 9.6e-05 21.4 0.5 0.044 12.7 0.0 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_oxidored PF12831.2 CCF44570.1 - 0.00021 20.5 0.2 0.0003 19.9 0.2 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 CCF44570.1 - 0.00052 18.6 1.1 0.0022 16.5 0.2 1.9 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.12 CCF44570.1 - 0.0065 15.5 0.1 0.012 14.7 0.0 1.4 1 0 0 1 1 1 1 Thi4 family ApbA PF02558.11 CCF44570.1 - 0.0074 15.7 0.2 0.016 14.6 0.1 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox_3 PF13738.1 CCF44570.1 - 0.0086 16.1 1.9 0.022 14.8 0.6 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CCF44570.1 - 0.016 14.1 1.1 0.016 14.1 0.8 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.16 CCF44570.1 - 0.059 12.9 0.2 0.12 11.9 0.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.9 CCF44570.1 - 0.062 12.6 0.1 0.1 11.9 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_18 PF12847.2 CCF44570.1 - 0.086 13.4 0.0 0.17 12.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain 3HCDH_N PF02737.13 CCF44570.1 - 0.098 12.3 0.1 0.15 11.6 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.1 CCF44570.1 - 0.1 12.8 0.1 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding MTS PF05175.9 CCF44570.1 - 0.14 11.5 0.1 0.22 10.8 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Pyr_redox_3 PF13738.1 CCF44571.1 - 3e-17 63.3 0.0 1.5e-16 61.0 0.0 2.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF44571.1 - 5e-14 51.9 0.0 4.7e-12 45.4 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.14 CCF44571.1 - 6.2e-11 41.1 0.0 9.3e-11 40.6 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.9 CCF44571.1 - 1e-06 28.7 0.0 2.1e-06 27.7 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF44571.1 - 2.3e-05 24.2 0.0 9.5e-05 22.3 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 CCF44571.1 - 4.3e-05 23.3 0.0 0.027 14.2 0.0 3.2 2 1 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.19 CCF44571.1 - 0.058 12.2 0.0 13 4.5 0.0 2.9 3 0 0 3 3 3 0 FAD dependent oxidoreductase Mqo PF06039.10 CCF44571.1 - 0.09 10.9 0.0 5.8 4.9 0.0 2.2 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) FAD_binding_2 PF00890.19 CCF44571.1 - 0.14 10.9 0.0 2.4 6.9 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.12 CCF44571.1 - 0.16 11.0 0.0 0.46 9.5 0.0 1.8 2 0 0 2 2 2 0 Thi4 family Anth_synt_I_N PF04715.8 CCF44572.1 - 3.7e-08 33.4 0.0 4.9e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Nif11 PF07862.6 CCF44573.1 - 0.1 12.5 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 Nitrogen fixation protein of unknown function Glyco_hydro_18 PF00704.23 CCF44575.1 - 1.6e-49 169.1 0.1 1.9e-49 168.9 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.14 CCF44575.1 - 8.9e-08 31.9 43.9 1.8e-07 30.9 11.6 2.9 2 1 1 3 3 3 2 Chitin recognition protein HET PF06985.6 CCF44576.1 - 3.7e-31 108.1 0.0 6.4e-31 107.3 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) adh_short_C2 PF13561.1 CCF44580.1 - 3.2e-27 95.8 0.8 3.6e-27 95.6 0.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF44580.1 - 6.2e-27 94.5 0.5 7.8e-27 94.2 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF44580.1 - 1.8e-14 53.8 0.2 2.4e-14 53.3 0.2 1.1 1 0 0 1 1 1 1 KR domain IncA PF04156.9 CCF44581.1 - 5.1e-07 29.4 65.3 0.013 15.1 11.3 4.3 1 1 3 4 4 4 3 IncA protein Filament PF00038.16 CCF44581.1 - 9.2e-06 25.3 51.3 3.6e-05 23.3 24.0 2.2 1 1 0 2 2 2 2 Intermediate filament protein Myosin_tail_1 PF01576.14 CCF44581.1 - 4.4e-05 21.4 62.8 0.0096 13.7 20.9 2.5 1 1 1 2 2 2 2 Myosin tail Spc7 PF08317.6 CCF44581.1 - 8.2e-05 21.4 52.4 0.0067 15.1 7.5 3.9 1 1 2 3 3 3 1 Spc7 kinetochore protein Tup_N PF08581.5 CCF44581.1 - 0.00014 21.9 28.1 0.21 11.7 0.9 5.4 2 1 3 5 5 5 3 Tup N-terminal AAA_13 PF13166.1 CCF44581.1 - 0.0006 18.4 20.2 0.0006 18.4 14.0 2.5 1 1 1 2 2 2 1 AAA domain CENP-Q PF13094.1 CCF44581.1 - 0.00086 19.3 26.8 0.00086 19.3 18.6 3.9 1 1 1 2 2 1 1 CENP-Q, a CENPA-CAD centromere complex subunit DUF2968 PF11180.3 CCF44581.1 - 0.0058 16.0 5.9 0.0058 16.0 4.1 4.6 1 1 2 4 4 3 1 Protein of unknown function (DUF2968) IFT57 PF10498.4 CCF44581.1 - 0.0064 15.2 11.2 0.0064 15.2 7.7 3.4 1 1 2 3 3 3 1 Intra-flagellar transport protein 57 MscS_porin PF12795.2 CCF44581.1 - 0.0083 15.4 70.3 0.044 13.1 8.2 4.1 1 1 3 4 4 4 1 Mechanosensitive ion channel porin domain SlyX PF04102.7 CCF44581.1 - 0.01 16.2 6.0 0.01 16.2 4.2 6.9 1 1 5 7 7 7 1 SlyX Rootletin PF15035.1 CCF44581.1 - 0.01 15.7 20.9 0.01 15.7 14.5 3.7 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion TMF_DNA_bd PF12329.3 CCF44581.1 - 0.013 15.2 14.4 0.013 15.2 10.0 6.0 2 1 4 6 6 6 0 TATA element modulatory factor 1 DNA binding Reo_sigmaC PF04582.7 CCF44581.1 - 0.016 14.3 35.1 0.034 13.3 7.1 3.5 1 1 3 4 4 4 0 Reovirus sigma C capsid protein Baculo_PEP_C PF04513.7 CCF44581.1 - 0.037 13.8 38.0 0.76 9.5 7.1 4.0 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus YmdB PF13277.1 CCF44581.1 - 0.038 13.0 0.2 0.097 11.6 0.2 1.8 1 0 0 1 1 1 0 YmdB-like protein GAS PF13851.1 CCF44581.1 - 0.041 13.0 58.8 0.88 8.7 13.4 4.5 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.4 CCF44581.1 - 0.046 13.5 56.5 0.023 14.5 8.5 4.5 1 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Mnd1 PF03962.10 CCF44581.1 - 0.047 13.3 53.5 0.11 12.0 4.8 4.5 1 1 2 3 3 3 0 Mnd1 family DUF4201 PF13870.1 CCF44581.1 - 0.05 13.0 51.4 1 8.7 5.4 5.6 1 1 4 5 5 5 0 Domain of unknown function (DUF4201) Occludin_ELL PF07303.8 CCF44581.1 - 0.061 14.0 1.1 0.061 14.0 0.8 5.4 1 1 2 5 5 5 0 Occludin homology domain Prefoldin_2 PF01920.15 CCF44581.1 - 0.063 13.0 57.8 0.099 12.4 4.0 6.8 2 1 4 6 6 6 0 Prefoldin subunit Tmemb_cc2 PF10267.4 CCF44581.1 - 0.064 11.8 47.3 0.66 8.4 21.8 2.9 1 1 2 3 3 3 0 Predicted transmembrane and coiled-coil 2 protein DUF3584 PF12128.3 CCF44581.1 - 0.094 10.0 64.1 0.81 6.9 16.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) AIP3 PF03915.8 CCF44581.1 - 0.097 11.5 43.0 0.32 9.8 9.7 2.2 1 1 1 2 2 2 0 Actin interacting protein 3 DUF948 PF06103.6 CCF44581.1 - 0.14 11.9 36.3 0.14 12.0 1.6 5.2 2 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) Laminin_I PF06008.9 CCF44581.1 - 0.19 11.0 63.8 0.63 9.3 23.1 2.8 1 1 1 2 2 2 0 Laminin Domain I WEMBL PF05701.6 CCF44581.1 - 0.2 10.1 67.1 0.28 9.5 35.3 2.6 1 1 1 2 2 2 0 Weak chloroplast movement under blue light DUF1664 PF07889.7 CCF44581.1 - 0.2 11.4 34.9 0.17 11.7 1.7 4.8 2 2 3 5 5 5 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.5 CCF44581.1 - 0.55 10.3 37.1 0.46 10.5 5.6 4.2 1 1 2 4 4 4 0 Fibrinogen alpha/beta chain family ATG16 PF08614.6 CCF44581.1 - 0.58 9.9 62.4 0.53 10.0 5.2 4.1 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) BicD PF09730.4 CCF44581.1 - 0.58 8.4 52.9 0.062 11.6 19.3 2.4 1 1 1 2 2 2 0 Microtubule-associated protein Bicaudal-D AAA_27 PF13514.1 CCF44581.1 - 0.69 7.5 60.6 0.072 10.7 29.0 2.1 1 1 1 2 2 2 0 AAA domain STAT_alpha PF01017.15 CCF44581.1 - 0.75 9.4 33.9 0.35 10.5 0.6 3.9 2 1 2 4 4 4 0 STAT protein, all-alpha domain TPR_MLP1_2 PF07926.7 CCF44581.1 - 0.81 9.4 69.6 5.4 6.7 12.1 5.3 1 1 4 5 5 5 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.1 CCF44581.1 - 1.1 8.1 59.9 0.27 10.1 15.8 3.3 1 1 1 2 2 1 0 Domain of unknown function (DUF4407) FliJ PF02050.11 CCF44581.1 - 1.5 8.9 54.7 0.086 12.9 3.1 5.7 1 1 6 7 7 7 0 Flagellar FliJ protein ERM PF00769.14 CCF44581.1 - 1.9 7.9 58.4 0.062 12.8 15.2 3.1 1 1 2 3 3 3 0 Ezrin/radixin/moesin family EzrA PF06160.7 CCF44581.1 - 2 6.5 48.2 0.51 8.4 5.7 3.3 1 1 1 3 3 3 0 Septation ring formation regulator, EzrA DUF4510 PF14971.1 CCF44581.1 - 2.5 8.2 25.7 5.6 7.1 10.5 4.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4510) Prefoldin PF02996.12 CCF44581.1 - 3.3 7.3 51.5 0.062 12.9 3.0 7.1 2 2 4 7 7 7 0 Prefoldin subunit PspA_IM30 PF04012.7 CCF44581.1 - 3.4 6.9 66.5 0.54 9.5 7.5 4.5 1 1 1 3 3 3 0 PspA/IM30 family MAD PF05557.8 CCF44581.1 - 4 5.4 58.9 1.6 6.7 6.8 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein HrpB7 PF09486.5 CCF44581.1 - 6.7 6.6 50.9 1.1 9.2 9.2 3.4 1 1 2 3 3 3 0 Bacterial type III secretion protein (HrpB7) Troponin PF00992.15 CCF44581.1 - 7.4 6.6 47.9 0.75 9.8 4.9 4.3 1 1 3 4 4 4 0 Troponin DUF3552 PF12072.3 CCF44581.1 - 9.5 5.3 58.4 0.81 8.8 10.4 4.0 1 1 3 4 4 2 0 Domain of unknown function (DUF3552) Glyco_hydro_43 PF04616.9 CCF44582.1 - 4.3e-23 81.7 0.1 4.9e-23 81.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Proteasome_A_N PF10584.4 CCF44582.1 - 0.034 13.4 0.0 0.063 12.6 0.0 1.4 1 0 0 1 1 1 0 Proteasome subunit A N-terminal signature DUF4387 PF14330.1 CCF44583.1 - 1.3e-29 102.4 0.0 2.3e-29 101.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4387) DUF1446 PF07287.6 CCF44583.1 - 8.6e-05 21.1 0.0 0.00012 20.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1446) HMG_box PF00505.14 CCF44585.1 - 1.9e-25 88.9 1.7 2.8e-25 88.3 1.2 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 CCF44585.1 - 3.9e-19 68.8 2.1 6e-19 68.1 1.5 1.3 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.1 CCF44585.1 - 0.00077 19.2 0.7 0.0017 18.0 0.5 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box 5 DUF1014 PF06244.7 CCF44585.1 - 0.018 15.2 0.3 0.046 13.9 0.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1014) Prefoldin_2 PF01920.15 CCF44586.1 - 1.2e-08 34.6 1.4 1.3e-08 34.5 1.0 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF869 PF05911.6 CCF44586.1 - 0.0043 15.3 0.6 0.0044 15.3 0.4 1.0 1 0 0 1 1 1 1 Plant protein of unknown function (DUF869) Prefoldin PF02996.12 CCF44586.1 - 0.0073 15.9 0.7 0.0073 15.9 0.5 1.0 1 0 0 1 1 1 1 Prefoldin subunit bZIP_1 PF00170.16 CCF44586.1 - 0.0093 15.9 1.4 0.011 15.6 1.0 1.1 1 0 0 1 1 1 1 bZIP transcription factor Baculo_PEP_C PF04513.7 CCF44586.1 - 0.011 15.5 0.1 0.011 15.5 0.1 1.0 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-F_leu_zip PF10473.4 CCF44586.1 - 0.012 15.5 1.8 0.012 15.5 1.2 1.1 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin_1 PF12718.2 CCF44586.1 - 0.02 14.7 0.7 0.02 14.7 0.5 1.1 1 0 0 1 1 1 0 Tropomyosin like XhlA PF10779.4 CCF44586.1 - 0.029 14.2 0.9 0.034 14.0 0.6 1.2 1 0 0 1 1 1 0 Haemolysin XhlA WXG100 PF06013.7 CCF44586.1 - 0.033 14.1 0.3 0.04 13.9 0.2 1.1 1 0 0 1 1 1 0 Proteins of 100 residues with WXG Cast PF10174.4 CCF44586.1 - 0.033 12.2 0.7 0.035 12.1 0.5 1.0 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone DUF1664 PF07889.7 CCF44586.1 - 0.038 13.7 0.3 0.038 13.7 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.6 CCF44586.1 - 0.046 13.6 2.7 0.094 12.6 1.9 1.5 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) PspA_IM30 PF04012.7 CCF44586.1 - 0.049 12.9 0.8 0.053 12.8 0.6 1.0 1 0 0 1 1 1 0 PspA/IM30 family DUF972 PF06156.8 CCF44586.1 - 0.054 13.8 0.4 0.055 13.8 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) ORF6C PF10552.4 CCF44586.1 - 0.061 13.0 0.7 0.067 12.9 0.5 1.2 1 0 0 1 1 1 0 ORF6C domain DUF1319 PF07028.6 CCF44586.1 - 0.065 13.4 0.2 0.068 13.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) MtrG PF04210.8 CCF44586.1 - 0.065 12.9 0.2 0.072 12.7 0.1 1.2 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G ApoLp-III PF07464.6 CCF44586.1 - 0.083 12.9 0.2 0.083 12.9 0.2 1.1 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) SLIDE PF09111.5 CCF44586.1 - 0.091 12.4 0.2 0.091 12.4 0.1 1.0 1 0 0 1 1 1 0 SLIDE E2 PF08199.6 CCF44586.1 - 0.094 12.3 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage E2-like protein Fib_alpha PF08702.5 CCF44586.1 - 0.11 12.5 0.2 0.12 12.4 0.1 1.0 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF2730 PF10805.3 CCF44586.1 - 0.13 12.0 0.7 0.13 11.9 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) MFS_1 PF07690.11 CCF44587.1 - 2e-16 59.6 12.1 2.5e-16 59.3 8.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF44587.1 - 1.8e-07 30.1 3.0 2.4e-07 29.7 1.8 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.1 CCF44587.1 - 3.7e-05 22.3 7.3 4.6e-05 22.0 5.1 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein DUF3816 PF12822.2 CCF44587.1 - 0.56 10.0 9.7 0.6 9.9 6.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3816) X PF00739.14 CCF44588.1 - 0.07 13.0 0.1 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Trans-activation protein X CLASP_N PF12348.3 CCF44588.1 - 0.11 11.8 0.2 0.94 8.7 0.0 2.5 3 0 0 3 3 3 0 CLASP N terminal MFS_1 PF07690.11 CCF44590.1 - 5.9e-22 77.8 30.8 1.5e-21 76.5 17.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3328 PF11807.3 CCF44592.1 - 2.1e-12 47.2 0.2 2.7e-11 43.5 0.2 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) PsbN PF02468.10 CCF44592.1 - 0.13 11.8 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 Photosystem II reaction centre N protein (psbN) Methyltransf_31 PF13847.1 CCF44593.1 - 1.1e-14 54.2 0.0 2e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF44593.1 - 8.8e-13 48.8 0.0 1.4e-12 48.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF44593.1 - 1.3e-10 41.6 0.2 1.3e-09 38.4 0.1 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF44593.1 - 2.2e-09 36.6 0.0 2.2e-08 33.3 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_12 PF08242.7 CCF44593.1 - 5.1e-09 36.5 0.0 7.9e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF44593.1 - 2.1e-08 34.1 0.1 1.8e-07 31.1 0.2 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF44593.1 - 4.3e-07 29.7 0.0 6.2e-07 29.2 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF44593.1 - 9.1e-07 29.1 0.0 8.1e-06 26.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF44593.1 - 2.4e-06 26.8 0.0 1.7e-05 24.0 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.9 CCF44593.1 - 2.7e-06 26.8 0.0 4.5e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.13 CCF44593.1 - 0.0027 16.9 0.0 0.0049 16.0 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase PCMT PF01135.14 CCF44593.1 - 0.0069 15.9 0.0 0.014 14.9 0.0 1.5 1 1 1 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FmrO PF07091.6 CCF44593.1 - 0.012 14.5 0.0 0.024 13.6 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Methyltransf_32 PF13679.1 CCF44593.1 - 0.029 14.0 0.0 0.044 13.4 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain DUF713 PF05218.9 CCF44593.1 - 0.12 12.1 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF713) CMAS PF02353.15 CCF44593.1 - 0.14 11.2 0.0 0.24 10.4 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Condensation PF00668.15 CCF44594.1 - 8.9e-22 77.3 0.0 3.2e-21 75.4 0.0 1.9 1 1 0 1 1 1 1 Condensation domain ArfGap PF01412.13 CCF44595.1 - 8.2e-41 138.4 0.8 1.6e-40 137.5 0.6 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf 2-Hacid_dh_C PF02826.14 CCF44596.1 - 3.7e-52 176.0 0.1 7e-52 175.1 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 CCF44596.1 - 1.5e-35 121.6 1.1 4e-35 120.1 0.4 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ACT PF01842.20 CCF44596.1 - 0.00085 18.7 2.0 0.0042 16.5 0.0 2.9 3 0 0 3 3 3 1 ACT domain XdhC_C PF13478.1 CCF44596.1 - 0.041 14.1 0.0 0.093 13.0 0.0 1.6 1 0 0 1 1 1 0 XdhC Rossmann domain DUF21 PF01595.15 CCF44597.1 - 2.2e-32 111.8 0.0 3.4e-32 111.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.23 CCF44597.1 - 0.00016 21.3 0.3 0.088 12.6 0.0 2.6 2 0 0 2 2 2 2 CBS domain Lactonase PF10282.4 CCF44598.1 - 1.6e-18 66.9 0.0 2.3e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller WD40 PF00400.27 CCF44598.1 - 0.029 14.2 0.1 7.3 6.6 0.0 3.9 5 0 0 5 5 5 0 WD domain, G-beta repeat ABC_tran PF00005.22 CCF44599.1 - 7.9e-45 152.5 0.0 3.9e-25 88.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 CCF44599.1 - 8.7e-37 127.0 16.4 7.5e-22 78.0 3.7 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.14 CCF44599.1 - 3.9e-08 32.7 0.6 0.0082 15.4 0.0 4.0 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF44599.1 - 7.3e-08 32.7 1.6 0.098 12.6 0.1 4.4 3 1 0 4 4 4 1 AAA domain AAA_29 PF13555.1 CCF44599.1 - 2e-06 27.2 0.3 0.0056 16.1 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 CCF44599.1 - 5.7e-06 26.4 0.6 0.11 12.5 0.1 3.2 2 2 0 2 2 2 2 AAA domain AAA_25 PF13481.1 CCF44599.1 - 6.1e-06 25.7 0.1 0.014 14.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 CCF44599.1 - 1.7e-05 24.0 0.1 0.09 11.9 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 CCF44599.1 - 2.5e-05 24.3 0.3 0.011 15.7 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain AAA_10 PF12846.2 CCF44599.1 - 7.5e-05 22.3 1.1 0.17 11.2 0.1 3.3 4 0 0 4 4 3 2 AAA-like domain Miro PF08477.8 CCF44599.1 - 0.00013 22.4 0.0 0.42 11.1 0.0 2.5 2 0 0 2 2 2 2 Miro-like protein AAA PF00004.24 CCF44599.1 - 0.00039 20.6 0.9 0.049 13.8 0.1 3.1 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.1 CCF44599.1 - 0.0014 18.9 0.5 0.3 11.3 0.2 2.3 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 CCF44599.1 - 0.0016 18.1 0.1 0.011 15.4 0.0 2.2 2 1 0 2 2 2 1 Archaeal ATPase MMR_HSR1 PF01926.18 CCF44599.1 - 0.0022 17.9 0.0 0.51 10.3 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF87 PF01935.12 CCF44599.1 - 0.005 16.6 2.5 0.41 10.4 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function DUF87 T2SE PF00437.15 CCF44599.1 - 0.0063 15.4 0.3 0.17 10.7 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 CCF44599.1 - 0.0066 15.9 0.5 3.6 7.0 0.1 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family RNA_helicase PF00910.17 CCF44599.1 - 0.0087 16.2 0.0 1.3 9.1 0.0 3.1 3 0 0 3 3 3 1 RNA helicase AAA_14 PF13173.1 CCF44599.1 - 0.021 14.6 0.3 0.46 10.3 0.0 2.6 3 0 0 3 3 2 0 AAA domain DUF815 PF05673.8 CCF44599.1 - 0.023 13.6 0.3 4.8 6.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) NACHT PF05729.7 CCF44599.1 - 0.033 13.8 0.3 0.33 10.5 0.0 2.3 2 0 0 2 2 2 0 NACHT domain Zeta_toxin PF06414.7 CCF44599.1 - 0.063 12.3 0.1 13 4.8 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin PduV-EutP PF10662.4 CCF44599.1 - 0.065 12.7 0.6 0.31 10.5 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.18 CCF44599.1 - 0.067 12.9 2.1 0.32 10.8 0.3 2.2 2 0 0 2 2 2 0 Dynamin family AAA_17 PF13207.1 CCF44599.1 - 0.071 13.9 0.3 3.9 8.3 0.1 2.7 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 CCF44599.1 - 0.071 12.8 2.3 9.7 5.9 0.1 3.7 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 CCF44599.1 - 0.087 13.1 0.8 2.1 8.6 0.0 2.7 2 1 0 2 2 2 0 AAA domain ABC_ATPase PF09818.4 CCF44599.1 - 0.094 11.2 0.1 3.9 5.9 0.0 2.5 3 0 0 3 3 3 0 Predicted ATPase of the ABC class DUF3595 PF12166.3 CCF44599.1 - 0.1 11.4 0.1 0.19 10.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3595) Adeno_IVa2 PF02456.10 CCF44599.1 - 0.12 11.0 0.1 1.5 7.3 0.0 2.1 2 0 0 2 2 2 0 Adenovirus IVa2 protein Viral_helicase1 PF01443.13 CCF44599.1 - 0.17 11.3 0.6 1.6 8.1 0.1 2.6 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase Rad17 PF03215.10 CCF44599.1 - 0.36 9.4 0.3 0.78 8.3 0.0 1.6 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein AAA_33 PF13671.1 CCF44599.1 - 0.47 10.3 1.4 1.2 9.0 0.1 2.2 2 0 0 2 2 2 0 AAA domain zf-C3HC4_2 PF13923.1 CCF44600.1 - 2.2e-08 33.9 14.9 0.00011 22.0 3.6 2.5 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF44600.1 - 3e-06 26.9 12.2 0.0004 20.1 2.9 2.4 2 0 0 2 2 2 2 Ring finger domain zf-RING_5 PF14634.1 CCF44600.1 - 7.2e-05 22.4 4.7 7.2e-05 22.4 3.3 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.20 CCF44600.1 - 7.7e-05 22.2 14.5 0.018 14.6 3.2 2.7 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CCF44600.1 - 0.00016 21.4 14.0 0.042 13.7 1.3 2.8 2 1 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 CCF44600.1 - 0.0029 17.2 1.1 0.0029 17.2 0.8 2.9 2 0 0 2 2 2 1 RING-type zinc-finger FYVE PF01363.16 CCF44600.1 - 0.0081 16.0 11.9 0.012 15.4 3.7 2.7 2 1 1 3 3 3 1 FYVE zinc finger zf-AD PF07776.10 CCF44600.1 - 0.3 11.0 0.0 0.3 11.0 0.0 3.7 2 2 2 4 4 4 0 Zinc-finger associated domain (zf-AD) Fer2 PF00111.22 CCF44600.1 - 1.4 8.7 11.3 8.4 6.2 0.2 3.3 2 1 1 3 3 3 0 2Fe-2S iron-sulfur cluster binding domain zf-RING_6 PF14835.1 CCF44600.1 - 2.4 8.0 7.6 2.2 8.1 0.8 2.4 2 0 0 2 2 2 0 zf-RING of BARD1-type protein SRP72 PF08492.7 CCF44600.1 - 3.7 7.9 8.3 0.16 12.3 0.7 2.4 3 0 0 3 3 3 0 SRP72 RNA-binding domain Ima1_N PF09779.4 CCF44600.1 - 6.1 7.3 8.2 0.24 11.9 0.2 2.5 2 1 0 2 2 2 0 Ima1 N-terminal domain Mito_carr PF00153.22 CCF44601.1 - 5.3e-10 38.8 0.1 1.4e-09 37.5 0.1 1.6 1 1 0 1 1 1 1 Mitochondrial carrier protein DUF719 PF05334.8 CCF44601.1 - 0.082 12.9 0.3 0.11 12.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF719) SRP-alpha_N PF04086.8 CCF44603.1 - 1e-50 172.7 0.0 9e-50 169.6 0.0 2.0 1 1 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal YIF1 PF03878.10 CCF44604.1 - 1.2e-25 90.0 0.5 1.5e-25 89.7 0.4 1.1 1 0 0 1 1 1 1 YIF1 ABC2_membrane PF01061.19 CCF44605.1 - 4.9e-42 143.4 33.4 8.2e-40 136.2 15.4 3.1 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.7 CCF44605.1 - 2.8e-32 110.4 0.0 8e-32 108.9 0.0 1.8 1 0 0 1 1 1 1 CDR ABC transporter ABC_tran PF00005.22 CCF44605.1 - 8.2e-17 61.7 0.1 1.7e-16 60.7 0.0 1.6 2 0 0 2 2 1 1 ABC transporter DUF258 PF03193.11 CCF44605.1 - 0.0001 21.5 0.0 0.00024 20.3 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_25 PF13481.1 CCF44605.1 - 0.00026 20.4 0.0 0.00052 19.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain ABC2_membrane_2 PF12679.2 CCF44605.1 - 0.00078 18.3 0.1 0.00078 18.3 0.1 2.9 2 1 0 3 3 3 1 ABC-2 family transporter protein AAA_16 PF13191.1 CCF44605.1 - 0.0011 18.9 0.0 0.0021 18.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.1 CCF44605.1 - 0.0019 17.6 0.2 0.0091 15.5 0.1 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain cobW PF02492.14 CCF44605.1 - 0.0021 17.5 0.1 0.0038 16.6 0.1 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 CCF44605.1 - 0.013 15.3 0.1 0.026 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CCF44605.1 - 0.024 14.9 0.0 0.044 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.14 CCF44605.1 - 0.03 13.5 0.0 1.4 8.1 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 CCF44605.1 - 0.12 12.5 0.0 0.37 10.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 CCF44605.1 - 0.16 12.8 0.0 0.33 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Involucrin_N PF10583.4 CCF44608.1 - 0.043 14.1 0.9 0.043 14.1 0.6 2.9 3 1 0 3 3 3 0 Involucrin of squamous epithelia N-terminus Aldedh PF00171.17 CCF44610.1 - 3.4e-96 322.3 0.0 4.3e-96 322.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 CCF44610.1 - 0.054 12.2 0.0 0.47 9.1 0.0 2.0 2 0 0 2 2 2 0 Acyl-CoA reductase (LuxC) adh_short_C2 PF13561.1 CCF44613.1 - 3.1e-31 108.9 1.4 3.6e-31 108.7 1.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF44613.1 - 2.5e-30 105.5 1.5 3.5e-30 105.1 1.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF44613.1 - 1.5e-13 50.8 0.7 3.5e-13 49.6 0.5 1.6 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 CCF44613.1 - 0.0082 15.0 0.1 0.012 14.5 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein MFS_1 PF07690.11 CCF44614.1 - 4.9e-16 58.3 11.4 5.5e-16 58.2 7.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily LEA_6 PF10714.4 CCF44615.1 - 0.1 12.4 1.3 0.82 9.5 0.1 2.2 2 0 0 2 2 2 0 Late embryogenesis abundant protein 18 CIAPIN1 PF05093.8 CCF44616.1 - 8.3e-35 118.8 1.9 1.3e-34 118.2 1.3 1.3 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Hom_end PF05204.9 CCF44616.1 - 0.036 14.0 0.0 0.097 12.6 0.0 1.7 1 0 0 1 1 1 0 Homing endonuclease ThiF PF00899.16 CCF44618.1 - 1.4e-19 70.2 0.0 2.3e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 ThiF family SOBP PF15279.1 CCF44619.1 - 0.00034 21.0 4.4 0.00034 21.0 3.0 1.1 1 0 0 1 1 1 1 Sine oculis-binding protein DUF1517 PF07466.6 CCF44620.1 - 0.11 11.5 11.4 0.12 11.3 7.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) PspC PF04024.7 CCF44620.1 - 0.22 10.9 2.2 0.31 10.5 1.5 1.3 1 0 0 1 1 1 0 PspC domain Glyco_hydro_76 PF03663.9 CCF44621.1 - 3.7e-84 283.2 3.7 4.5e-84 282.9 2.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Fungal_trans_2 PF11951.3 CCF44623.1 - 1.1e-08 34.0 0.2 1.7e-08 33.4 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain E1-E2_ATPase PF00122.15 CCF44624.1 - 6.3e-67 224.9 1.5 6.3e-67 224.9 1.0 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CCF44624.1 - 1.6e-32 112.5 8.4 1.6e-32 112.5 5.8 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CCF44624.1 - 5.1e-31 108.7 0.0 1.5e-29 103.9 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF44624.1 - 2.1e-18 66.0 0.0 4.4e-18 65.0 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 CCF44624.1 - 1.9e-16 59.2 0.0 5.7e-16 57.7 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 CCF44624.1 - 3.1e-15 56.8 0.0 6.8e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CCF44624.1 - 0.00092 18.8 0.1 0.011 15.3 0.1 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase SieB PF14163.1 CCF44624.1 - 5.5 6.5 7.8 2.5 7.6 0.1 2.9 3 0 0 3 3 3 0 Superinfection exclusion protein B DUF2417 PF10329.4 CCF44625.1 - 5.9e-15 55.3 0.3 8.7e-15 54.7 0.2 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Abhydrolase_6 PF12697.2 CCF44625.1 - 2.9e-08 33.8 0.3 3.9e-08 33.4 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF44625.1 - 0.019 14.6 0.1 0.025 14.3 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family AA_permease_2 PF13520.1 CCF44626.1 - 4.1e-37 127.7 35.4 5.4e-37 127.3 24.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF44626.1 - 3.1e-18 65.3 31.5 3.8e-18 65.0 21.8 1.0 1 0 0 1 1 1 1 Amino acid permease Baculo_helicase PF04735.7 CCF44626.1 - 0.062 10.6 0.1 0.084 10.2 0.1 1.0 1 0 0 1 1 1 0 Baculovirus DNA helicase YpzG PF14139.1 CCF44627.1 - 0.064 13.1 0.5 0.083 12.8 0.4 1.3 1 0 0 1 1 1 0 YpzG-like protein MFS_1 PF07690.11 CCF44628.1 - 2.4e-30 105.4 18.8 3e-30 105.1 13.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Suf PF05843.9 CCF44630.1 - 6.5e-70 236.0 0.0 1e-69 235.3 0.0 1.3 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) ATXN-1_C PF12547.3 CCF44632.1 - 2 8.4 4.9 0.73 9.8 0.1 2.5 3 0 0 3 3 3 0 Capicua transcriptional repressor modulator HgmA PF04209.8 CCF44634.1 - 5.4e-151 502.7 0.0 6.2e-151 502.5 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase DUF3484 PF11983.3 CCF44635.1 - 0.058 14.2 0.0 0.14 13.0 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3484) Dicty_REP PF05086.7 CCF44635.1 - 0.36 8.5 3.5 0.31 8.7 2.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.3 CCF44635.1 - 5.6 6.7 10.2 7.8 6.2 7.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Shisa PF13908.1 CCF44637.1 - 0.071 13.2 0.0 0.08 13.1 0.0 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator GAPT PF11770.3 CCF44637.1 - 0.14 11.8 0.0 0.19 11.4 0.0 1.1 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) Acetyltransf_9 PF13527.1 CCF44640.1 - 1.9e-07 30.9 0.1 3.8e-07 29.9 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 CCF44640.1 - 0.00021 21.3 0.0 0.00039 20.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CCF44640.1 - 0.00032 20.6 0.0 0.001 19.0 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 CCF44640.1 - 0.024 14.7 0.0 0.11 12.6 0.0 2.1 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF44640.1 - 0.088 12.5 0.0 0.31 10.8 0.0 1.9 1 1 0 1 1 1 0 FR47-like protein Sas10_Utp3 PF04000.10 CCF44641.1 - 3.8e-07 30.2 0.7 4.2e-07 30.0 0.5 1.0 1 0 0 1 1 1 1 Sas10/Utp3/C1D family DUF4279 PF14106.1 CCF44641.1 - 0.04 13.7 0.1 0.041 13.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4279) ApbA_C PF08546.6 CCF44642.1 - 8.8e-17 61.2 0.1 1.8e-16 60.2 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 CCF44642.1 - 5.9e-09 35.5 0.0 1e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA RNase_PH PF01138.16 CCF44643.1 - 2.7e-17 63.2 0.0 4e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 zf-CCCH PF00642.19 CCF44644.1 - 1.1e-09 37.6 25.2 0.00042 19.9 0.1 5.5 4 1 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Amidase PF01425.16 CCF44645.1 - 2.9e-63 214.2 2.6 1.8e-58 198.4 0.4 2.0 1 1 1 2 2 2 2 Amidase DUF3759 PF12585.3 CCF44646.1 - 0.12 12.3 4.4 0.17 11.8 3.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3759) FUSC_2 PF13515.1 CCF44647.1 - 0.0014 18.4 0.3 0.0017 18.2 0.2 1.1 1 0 0 1 1 1 1 Fusaric acid resistance protein-like Methyltransf_32 PF13679.1 CCF44648.1 - 9.8e-21 73.9 0.0 1.7e-20 73.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF44648.1 - 1.1e-05 24.8 0.0 0.00011 21.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_18 PF12847.2 CCF44648.1 - 1.9e-05 25.2 0.0 4.5e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF44648.1 - 5.8e-05 22.7 0.0 9.4e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.10 CCF44648.1 - 0.004 16.3 0.0 0.0071 15.5 0.0 1.4 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_4 PF02390.12 CCF44648.1 - 0.0099 14.9 0.0 0.017 14.2 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.7 CCF44648.1 - 0.02 15.3 0.1 0.052 14.0 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 CCF44648.1 - 0.14 12.6 0.0 0.34 11.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Pkinase PF00069.20 CCF44653.1 - 3.4e-69 232.8 0.0 5.9e-69 232.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF44653.1 - 2e-49 168.0 0.0 3.4e-49 167.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF44653.1 - 0.00059 18.8 0.0 0.0017 17.3 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 CCF44653.1 - 0.029 13.4 0.0 0.059 12.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF952 PF06108.7 CCF44654.1 - 1.1e-13 50.8 0.0 1.4e-13 50.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF952) AMP-binding PF00501.23 CCF44655.1 - 1.7e-22 79.4 0.1 2.2e-22 79.0 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF44655.1 - 2e-14 54.3 0.6 3.4e-14 53.5 0.4 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Ferric_reduct PF01794.14 CCF44656.1 - 1.2e-16 60.9 15.6 3e-16 59.6 10.8 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 CCF44656.1 - 0.0016 18.3 0.0 0.015 15.1 0.0 2.2 2 0 0 2 2 2 1 FAD-binding domain FAD_binding_8 PF08022.7 CCF44658.1 - 2.4e-18 65.9 0.7 4.9e-18 64.9 0.0 1.8 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.14 CCF44658.1 - 4.7e-16 59.0 9.6 4.7e-16 59.0 6.7 2.3 1 1 1 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.19 CCF44658.1 - 0.0013 18.8 0.0 0.0034 17.4 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain DUF2272 PF10030.4 CCF44658.1 - 0.11 11.9 1.3 0.82 9.1 0.2 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2272) DUF572 PF04502.8 CCF44659.1 - 7e-73 245.6 9.4 8.3e-73 245.4 6.5 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) Rubredoxin PF00301.15 CCF44659.1 - 0.037 13.8 0.1 0.1 12.4 0.1 1.8 1 0 0 1 1 1 0 Rubredoxin Benyvirus_14KDa PF07255.6 CCF44659.1 - 0.1 12.4 0.2 0.22 11.3 0.1 1.5 1 1 0 1 1 1 0 Benyvirus 14KDa protein DUF951 PF06107.6 CCF44659.1 - 0.12 11.8 1.2 6.9 6.2 0.0 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF951) zf-FCS PF06467.9 CCF44659.1 - 0.27 10.9 1.4 0.38 10.4 0.1 1.9 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif His_Phos_1 PF00300.17 CCF44662.1 - 1.2e-08 35.1 0.0 1.4e-08 35.0 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Mitochondr_Som1 PF11093.3 CCF44662.1 - 0.083 12.7 0.0 0.1 12.4 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial export protein Som1 MFS_1 PF07690.11 CCF44666.1 - 1.8e-45 155.2 27.0 1.8e-45 155.2 18.7 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF44666.1 - 4.3e-15 55.2 3.4 4.3e-15 55.2 2.4 2.6 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_2 PF13347.1 CCF44666.1 - 4.1e-07 28.7 1.5 4.1e-07 28.7 1.0 2.9 3 1 1 4 4 4 1 MFS/sugar transport protein TRI12 PF06609.8 CCF44666.1 - 3.1e-05 22.4 5.8 5e-05 21.6 4.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.8 CCF44666.1 - 0.00039 18.6 4.5 0.00039 18.6 3.1 2.1 2 0 0 2 2 2 1 Transmembrane secretion effector DUF3317 PF11779.3 CCF44666.1 - 0.14 11.6 0.9 0.33 10.4 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3317) Methyltransf_11 PF08241.7 CCF44668.1 - 1.3e-07 31.9 0.0 1.9e-05 25.0 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF44668.1 - 2e-05 24.3 0.0 2.9e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF44668.1 - 6.4e-05 23.2 0.1 0.0035 17.6 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF44668.1 - 0.00019 21.9 0.0 0.00028 21.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF44668.1 - 0.0018 18.6 0.1 0.02 15.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF44668.1 - 0.0066 16.0 0.0 0.66 9.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Mito_fiss_reg PF05308.6 CCF44668.1 - 0.52 9.6 4.5 0.098 12.0 0.7 1.6 2 0 0 2 2 2 0 Mitochondrial fission regulator CAP_N PF01213.14 CCF44668.1 - 0.74 9.0 7.6 1.3 8.2 5.2 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Metallophos PF00149.23 CCF44670.1 - 5.8e-42 143.3 0.7 9.3e-42 142.6 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Tyrosinase PF00264.15 CCF44672.1 - 1.4e-40 139.8 0.2 1.9e-40 139.4 0.1 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase adh_short_C2 PF13561.1 CCF44673.1 - 1.9e-17 63.8 0.0 2.2e-17 63.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF44673.1 - 5.1e-15 55.7 0.3 8.5e-15 55.0 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF44673.1 - 0.0019 17.8 0.1 0.0029 17.3 0.1 1.2 1 0 0 1 1 1 1 KR domain HTH_28 PF13518.1 CCF44675.1 - 0.003 17.5 1.0 0.0067 16.4 0.3 2.0 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_IS630 PF01710.11 CCF44675.1 - 0.011 15.4 0.4 0.019 14.6 0.3 1.4 1 0 0 1 1 1 0 Transposase HTH_23 PF13384.1 CCF44675.1 - 0.017 14.7 1.9 0.02 14.5 0.4 1.9 2 0 0 2 2 2 0 Homeodomain-like domain Pkinase PF00069.20 CCF44676.1 - 9.5e-40 136.3 0.0 2.3e-39 135.0 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF44676.1 - 4e-21 75.2 0.0 6.3e-21 74.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF44676.1 - 6.9e-08 31.7 0.0 1.6e-05 24.0 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 CCF44676.1 - 1e-06 28.6 0.2 0.0019 17.9 0.1 3.0 3 1 0 4 4 4 2 Phosphotransferase enzyme family PAS_9 PF13426.1 CCF44676.1 - 0.00057 20.2 0.0 0.0014 18.9 0.0 1.6 1 0 0 1 1 1 1 PAS domain Seadorna_VP7 PF07387.6 CCF44676.1 - 0.0048 15.7 0.0 0.0076 15.1 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.9 CCF44676.1 - 0.012 14.6 0.0 0.021 13.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PAS PF00989.19 CCF44676.1 - 0.014 15.1 0.1 0.077 12.7 0.0 2.2 1 1 1 2 2 2 0 PAS fold PAS_4 PF08448.5 CCF44676.1 - 0.022 14.7 0.0 0.056 13.4 0.0 1.7 1 0 0 1 1 1 0 PAS fold PAS_9 PF13426.1 CCF44677.1 - 1.7e-13 50.8 0.0 3.9e-13 49.6 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.5 CCF44677.1 - 3.3e-07 30.3 0.1 2.5e-06 27.4 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS PF00989.19 CCF44677.1 - 0.0014 18.4 0.0 0.0043 16.8 0.0 1.8 1 0 0 1 1 1 1 PAS fold RGS PF00615.14 CCF44677.1 - 0.0023 18.0 0.8 0.038 14.1 0.0 2.8 2 1 0 2 2 2 1 Regulator of G protein signaling domain Baculo_p74 PF04583.7 CCF44677.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 Baculoviridae p74 conserved region MFS_1 PF07690.11 CCF44678.1 - 1.9e-09 36.7 33.4 1.9e-09 36.7 23.2 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.11 CCF44678.1 - 5.1e-06 26.0 3.5 5.1e-06 26.0 2.4 2.8 3 0 0 3 3 3 2 Ion channel regulatory protein UNC-93 DUF1295 PF06966.7 CCF44680.1 - 7.5e-19 67.9 0.0 1.1e-18 67.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.9 CCF44680.1 - 9e-05 22.6 0.0 0.00018 21.6 0.0 1.6 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 CCF44680.1 - 0.00037 20.5 0.0 0.00071 19.6 0.0 1.5 1 0 0 1 1 1 1 Phospholipid methyltransferase Steroid_dh PF02544.11 CCF44680.1 - 0.0012 18.6 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase ERG4_ERG24 PF01222.12 CCF44680.1 - 0.013 14.0 0.0 0.015 13.8 0.0 1.2 1 0 0 1 1 1 0 Ergosterol biosynthesis ERG4/ERG24 family NDT80_PhoG PF05224.7 CCF44681.1 - 1.5e-33 116.3 0.0 1.3e-32 113.2 0.0 2.0 2 0 0 2 2 2 1 NDT80 / PhoG like DNA-binding family bZIP_1 PF00170.16 CCF44682.1 - 0.00081 19.3 10.7 0.00081 19.3 7.4 2.1 1 1 1 2 2 2 1 bZIP transcription factor DUF904 PF06005.7 CCF44682.1 - 0.026 14.7 4.0 0.045 14.0 2.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF904) Mnd1 PF03962.10 CCF44682.1 - 0.029 14.0 4.4 0.043 13.4 3.0 1.2 1 0 0 1 1 1 0 Mnd1 family DUF2962 PF11176.3 CCF44682.1 - 0.033 13.7 2.7 0.053 13.0 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2962) IncA PF04156.9 CCF44682.1 - 0.061 12.9 1.6 0.083 12.4 1.1 1.2 1 0 0 1 1 1 0 IncA protein Myc_target_1 PF15179.1 CCF44682.1 - 0.069 12.7 1.9 0.13 11.8 1.3 1.4 1 0 0 1 1 1 0 Myc target protein 1 DUF972 PF06156.8 CCF44682.1 - 0.093 13.0 0.7 0.18 12.1 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DUF342 PF03961.8 CCF44682.1 - 0.3 9.4 1.8 0.4 9.0 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DNase_NucA_NucB PF14040.1 CCF44683.1 - 0.0012 18.9 1.4 0.01 15.9 1.0 2.6 1 1 0 1 1 1 1 Deoxyribonuclease NucA/NucB GMC_oxred_C PF05199.8 CCF44684.1 - 5.3e-21 75.4 0.0 5.8e-21 75.3 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase Glyco_hydro_28 PF00295.12 CCF44685.1 - 0.0023 16.9 0.0 0.003 16.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Ribosomal_L18p PF00861.17 CCF44686.1 - 5.4e-41 139.5 0.2 5.4e-41 139.5 0.1 1.6 2 0 0 2 2 2 1 Ribosomal L18p/L5e family Ribosomal_L18_c PF14204.1 CCF44686.1 - 5.6e-34 116.5 9.4 5.6e-34 116.5 6.5 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Uteroglobin PF01099.12 CCF44686.1 - 0.34 10.7 3.8 2.5 7.9 0.1 2.7 2 1 1 3 3 3 0 Uteroglobin family HAD_2 PF13419.1 CCF44687.1 - 4.4e-14 53.0 0.0 5.1e-13 49.6 0.0 2.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Methyltransf_31 PF13847.1 CCF44688.1 - 1.7e-19 69.8 0.0 2.8e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF44688.1 - 2.2e-16 60.1 0.0 8e-16 58.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF44688.1 - 4.9e-15 56.0 0.0 1.1e-14 54.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF44688.1 - 1.2e-14 54.5 0.0 3.4e-14 53.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF44688.1 - 3.4e-14 52.5 0.0 1.6e-13 50.2 0.0 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 CCF44688.1 - 7.9e-12 45.4 0.0 5.7e-11 42.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF44688.1 - 5.1e-11 42.6 0.1 1.7e-10 40.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF44688.1 - 1.2e-09 38.0 0.0 1.8e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 CCF44688.1 - 2e-05 24.2 0.0 4.6e-05 23.0 0.0 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TPMT PF05724.6 CCF44688.1 - 3.3e-05 23.4 0.0 5.8e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_24 PF13578.1 CCF44688.1 - 0.0025 18.6 0.0 0.0067 17.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain CheR PF01739.13 CCF44688.1 - 0.0072 15.6 0.0 2 7.6 0.0 2.2 1 1 1 2 2 2 2 CheR methyltransferase, SAM binding domain UPF0020 PF01170.13 CCF44688.1 - 0.0074 15.8 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 MTS PF05175.9 CCF44688.1 - 0.01 15.2 0.0 0.022 14.1 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_3 PF01596.12 CCF44688.1 - 0.048 12.7 0.0 0.16 11.0 0.0 1.8 2 0 0 2 2 2 0 O-methyltransferase SAM_2 PF07647.12 CCF44689.1 - 3.7e-14 52.3 0.0 8.1e-14 51.2 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.1 CCF44689.1 - 1.5e-13 50.0 0.0 4.1e-13 48.6 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 CCF44689.1 - 2.9e-10 39.3 0.0 6.3e-10 38.2 0.0 1.6 1 0 0 1 1 1 1 SH3 domain PH PF00169.24 CCF44689.1 - 6.1e-09 36.0 0.0 1.4e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 CCF44689.1 - 1.5e-05 25.1 0.1 4.6e-05 23.6 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain SH3_2 PF07653.12 CCF44689.1 - 5.3e-05 22.6 0.0 0.00011 21.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_1 PF00536.25 CCF44689.1 - 0.051 13.7 0.0 0.093 12.9 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PH_8 PF15409.1 CCF44689.1 - 0.087 12.9 0.0 0.54 10.3 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain DUF1546 PF07571.8 CCF44690.1 - 9.8e-28 96.1 0.0 2e-27 95.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1546) TAF PF02969.12 CCF44690.1 - 1.5e-21 76.1 0.0 3.5e-21 74.9 0.0 1.6 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.19 CCF44690.1 - 0.00065 19.7 0.1 0.0016 18.5 0.0 1.7 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 CCF44690.1 - 0.008 16.2 0.0 0.024 14.6 0.0 1.8 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 CCF44690.1 - 0.094 12.4 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Bromodomain associated Ofd1_CTDD PF10637.4 CCF44692.1 - 4.6e-99 330.8 0.0 1.7e-90 302.7 0.0 2.1 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_3 PF13640.1 CCF44692.1 - 5.2e-15 55.7 0.0 1.4e-14 54.3 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 CCF44692.1 - 0.0078 15.8 0.0 0.026 14.1 0.0 1.9 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Paf1 PF03985.8 CCF44692.1 - 1.3 7.6 0.0 1.3 7.6 0.0 2.2 1 1 0 2 2 2 0 Paf1 Lyase_1 PF00206.15 CCF44693.1 - 7e-58 196.2 0.0 9.3e-58 195.8 0.0 1.1 1 0 0 1 1 1 1 Lyase AKNA PF12443.3 CCF44693.1 - 0.01 15.8 0.0 0.021 14.8 0.0 1.6 1 0 0 1 1 1 1 AT-hook-containing transcription factor Fungal_trans PF04082.13 CCF44694.1 - 2.7e-12 46.0 0.3 6e-12 44.9 0.2 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain AAA_16 PF13191.1 CCF44694.1 - 0.0099 15.8 0.0 0.025 14.5 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Anticodon_1 PF08264.8 CCF44694.1 - 0.13 12.0 0.1 0.55 9.9 0.0 2.1 2 0 0 2 2 2 0 Anticodon-binding domain of tRNA HrpF PF06266.7 CCF44694.1 - 0.15 12.2 0.8 14 5.9 0.1 3.1 3 0 0 3 3 3 0 HrpF protein DUF2976 PF11190.3 CCF44695.1 - 0.69 9.4 3.3 1.7 8.1 1.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2976) Glyco_hydro_76 PF03663.9 CCF44696.1 - 2.5e-82 277.2 9.3 2.9e-82 277.0 6.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 SAP PF02037.22 CCF44697.1 - 1.4e-13 50.0 0.3 1.7e-13 49.6 0.2 1.1 1 0 0 1 1 1 1 SAP domain HeH PF12949.2 CCF44697.1 - 0.0073 15.8 0.2 0.014 14.9 0.1 1.6 1 1 0 1 1 1 1 HeH/LEM domain Armet PF10208.4 CCF44697.1 - 0.033 13.8 0.0 0.043 13.4 0.0 1.2 1 0 0 1 1 1 0 Degradation arginine-rich protein for mis-folding PaaSYMP PF14738.1 CCF44697.1 - 0.063 13.0 0.0 0.076 12.7 0.0 1.1 1 0 0 1 1 1 0 Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1 Metallophos PF00149.23 CCF44699.1 - 6.1e-12 45.3 0.0 1.1e-11 44.4 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CCF44699.1 - 1.3e-05 25.0 0.0 2.4e-05 24.2 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Tyrosinase PF00264.15 CCF44701.1 - 7.5e-40 137.4 0.5 1e-39 137.0 0.4 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase Cyt-b5 PF00173.23 CCF44703.1 - 1.6e-14 53.4 0.0 3e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_1 PF00175.16 CCF44703.1 - 0.086 13.4 0.0 0.55 10.8 0.0 2.4 2 1 0 2 2 2 0 Oxidoreductase NAD-binding domain Macoilin PF09726.4 CCF44703.1 - 9.1 4.4 10.8 0.87 7.7 3.0 1.9 2 0 0 2 2 2 0 Transmembrane protein DDE_1 PF03184.14 CCF44704.1 - 1e-13 50.9 0.0 1.3e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease CAF1A PF12253.3 CCF44705.1 - 9.2e-19 67.3 3.1 9.2e-19 67.3 2.1 3.5 3 1 0 3 3 3 1 Chromatin assembly factor 1 subunit A MIP-T3 PF10243.4 CCF44705.1 - 0.0098 14.4 33.4 0.015 13.7 23.2 1.4 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 Ycf1 PF05758.7 CCF44705.1 - 0.037 11.7 14.1 0.052 11.2 9.8 1.2 1 0 0 1 1 1 0 Ycf1 Hamartin PF04388.7 CCF44705.1 - 0.26 9.9 16.1 0.36 9.4 11.2 1.1 1 0 0 1 1 1 0 Hamartin protein Peptidase_S64 PF08192.6 CCF44705.1 - 7.1 4.8 9.9 9.3 4.4 6.9 1.2 1 0 0 1 1 1 0 Peptidase family S64 adh_short PF00106.20 CCF44706.1 - 1.9e-16 60.4 0.7 2.1e-16 60.3 0.5 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF44706.1 - 1.6e-07 31.1 0.1 1.8e-07 31.0 0.1 1.1 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.15 CCF44706.1 - 4.2e-07 30.1 0.1 5.1e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Saccharop_dh PF03435.13 CCF44706.1 - 1.6e-05 24.0 0.3 1.9e-05 23.8 0.2 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase Epimerase PF01370.16 CCF44706.1 - 0.00013 21.4 0.1 0.00016 21.2 0.1 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 CCF44706.1 - 0.00053 19.8 0.0 0.00064 19.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.3 CCF44706.1 - 0.0013 18.4 1.2 0.0026 17.5 0.8 1.5 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_10 PF13460.1 CCF44706.1 - 0.0038 17.2 1.0 0.0051 16.8 0.7 1.2 1 0 0 1 1 1 1 NADH(P)-binding 2-Hacid_dh_C PF02826.14 CCF44706.1 - 0.013 14.6 0.3 0.018 14.1 0.2 1.4 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.10 CCF44706.1 - 0.018 13.9 0.0 0.02 13.7 0.0 1.0 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein THF_DHG_CYH_C PF02882.14 CCF44706.1 - 0.035 13.1 0.2 0.082 11.9 0.0 1.6 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Trp_halogenase PF04820.9 CCF44706.1 - 0.045 12.3 1.9 0.057 12.0 1.3 1.0 1 0 0 1 1 1 0 Tryptophan halogenase OMPdecase PF00215.19 CCF44706.1 - 0.16 11.3 0.5 9.4 5.5 0.0 2.1 2 0 0 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family ThiF PF00899.16 CCF44706.1 - 0.56 10.0 4.6 2.6 7.8 1.4 2.0 1 1 1 2 2 2 0 ThiF family Amidoligase_2 PF12224.3 CCF44707.1 - 1.8e-20 73.6 0.0 5.5e-12 45.8 0.0 3.3 3 0 0 3 3 3 3 Putative amidoligase enzyme Catalase PF00199.14 CCF44710.1 - 5.3e-182 604.7 2.0 6.8e-182 604.3 1.4 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.7 CCF44710.1 - 1.1e-10 41.2 0.0 2.4e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive Na_Ca_ex PF01699.19 CCF44711.1 - 0.029 13.9 0.1 0.029 13.9 0.1 2.6 2 1 0 2 2 2 0 Sodium/calcium exchanger protein Fungal_trans PF04082.13 CCF44712.1 - 1.5e-15 56.7 1.9 3.5e-15 55.5 1.1 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF44712.1 - 4.5e-08 32.8 13.1 8.1e-08 32.0 9.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Clat_adaptor_s PF01217.15 CCF44712.1 - 0.039 13.6 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 Clathrin adaptor complex small chain AA_permease PF00324.16 CCF44713.1 - 3.4e-34 118.0 17.7 3.5e-21 75.0 9.4 2.0 2 0 0 2 2 2 2 Amino acid permease ABM PF03992.11 CCF44714.1 - 0.003 17.5 0.0 0.024 14.6 0.0 2.0 2 0 0 2 2 2 1 Antibiotic biosynthesis monooxygenase H_kinase_N PF12282.3 CCF44715.1 - 0.12 12.0 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Signal transduction histidine kinase DUF1183 PF06682.7 CCF44716.1 - 9 5.8 7.1 13 5.2 4.9 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1183) Zn_clus PF00172.13 CCF44717.1 - 2.3e-06 27.4 8.9 3.8e-06 26.7 6.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tyrosinase PF00264.15 CCF44718.1 - 0.0017 18.5 0.0 0.0024 18.0 0.0 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase RALF PF05498.6 CCF44719.1 - 0.00034 21.3 0.6 0.00046 20.9 0.4 1.2 1 0 0 1 1 1 1 Rapid ALkalinization Factor (RALF) MIP-T3 PF10243.4 CCF44720.1 - 5.6 5.3 5.5 7.8 4.8 3.8 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 NAD_binding_6 PF08030.7 CCF44721.1 - 6.5e-15 55.3 0.0 1.5e-14 54.2 0.0 1.6 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 CCF44721.1 - 4.4e-13 49.4 8.2 8.3e-13 48.5 5.7 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 CCF44721.1 - 1.9e-11 43.7 0.0 4.7e-11 42.5 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.16 CCF44721.1 - 0.0015 19.0 0.1 0.27 11.7 0.0 2.4 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain PGG PF13962.1 CCF44721.1 - 0.046 13.3 0.3 0.094 12.3 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function MerC PF03203.9 CCF44721.1 - 0.17 12.2 5.2 0.31 11.4 3.0 1.9 1 1 0 1 1 1 0 MerC mercury resistance protein PDT PF00800.13 CCF44723.1 - 7e-64 214.7 0.0 9.1e-64 214.3 0.0 1.1 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.20 CCF44723.1 - 0.011 15.1 0.0 0.069 12.6 0.0 2.3 2 1 0 2 2 2 0 ACT domain Pkinase PF00069.20 CCF44724.1 - 3.1e-68 229.7 0.0 5.4e-68 228.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF44724.1 - 3.3e-50 170.5 0.0 5.4e-50 169.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.1 CCF44724.1 - 4.9e-29 100.3 0.0 9.5e-29 99.4 0.0 1.5 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.12 CCF44724.1 - 1.3e-15 56.9 0.2 5.3e-15 55.0 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 CCF44724.1 - 3.6e-15 55.8 0.1 6.5e-15 55.0 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.18 CCF44724.1 - 4.9e-13 49.3 0.0 9.6e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Kinase-like PF14531.1 CCF44724.1 - 5e-07 28.9 0.0 0.00016 20.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 CCF44724.1 - 0.046 12.7 0.0 0.084 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SAM_PNT PF02198.11 CCF44724.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Abhydrolase_6 PF12697.2 CCF44725.1 - 1.8e-25 90.1 2.5 2.1e-25 89.9 1.7 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF44725.1 - 2.1e-09 37.2 0.5 3.4e-09 36.6 0.4 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF44725.1 - 2.1e-05 24.1 0.3 0.08 12.4 0.0 2.3 2 1 0 2 2 2 2 alpha/beta hydrolase fold DUF900 PF05990.7 CCF44725.1 - 0.036 13.3 0.0 0.051 12.8 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.8 CCF44725.1 - 0.17 11.4 0.2 0.25 10.9 0.1 1.2 1 0 0 1 1 1 0 PGAP1-like protein SnoaL PF07366.7 CCF44727.1 - 1.9e-06 27.5 0.1 4.1e-06 26.3 0.1 1.6 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.2 CCF44727.1 - 0.00082 19.7 0.1 0.0019 18.5 0.1 1.6 1 0 0 1 1 1 1 SnoaL-like domain BBE PF08031.7 CCF44729.1 - 0.019 14.8 0.0 0.048 13.5 0.0 1.7 1 0 0 1 1 1 0 Berberine and berberine like UBA PF00627.26 CCF44730.1 - 5.1e-10 38.8 1.7 2.5e-08 33.5 0.0 2.6 2 0 0 2 2 2 2 UBA/TS-N domain NPR2 PF06218.6 CCF44731.1 - 1.3e-46 159.1 0.0 1.5e-46 158.9 0.0 1.0 1 0 0 1 1 1 1 Nitrogen permease regulator 2 Acyl_transf_1 PF00698.16 CCF44732.1 - 1.3e-26 93.6 0.2 1.9e-26 93.1 0.2 1.2 1 0 0 1 1 1 1 Acyl transferase domain CENP-Q PF13094.1 CCF44733.1 - 0.0023 17.9 8.7 0.0023 17.9 6.1 4.9 2 2 2 4 4 4 2 CENP-Q, a CENPA-CAD centromere complex subunit Tropomyosin_1 PF12718.2 CCF44733.1 - 0.0031 17.3 7.1 0.0031 17.3 4.9 6.0 2 2 3 5 5 5 4 Tropomyosin like Filament PF00038.16 CCF44733.1 - 0.1 12.0 61.8 1.1 8.6 9.2 4.9 2 1 3 5 5 5 0 Intermediate filament protein XG_FTase PF03254.8 CCF44733.1 - 0.12 10.8 4.5 0.29 9.5 3.1 1.6 1 0 0 1 1 1 0 Xyloglucan fucosyltransferase Reo_sigmaC PF04582.7 CCF44733.1 - 0.13 11.3 9.5 0.72 8.9 0.5 3.2 2 1 0 2 2 2 0 Reovirus sigma C capsid protein Mnd1 PF03962.10 CCF44733.1 - 0.14 11.8 62.1 0.026 14.2 9.3 4.4 2 1 1 4 4 4 0 Mnd1 family AAA_27 PF13514.1 CCF44733.1 - 0.21 9.2 65.8 0.07 10.8 10.7 2.1 2 0 0 2 2 2 0 AAA domain Fib_alpha PF08702.5 CCF44733.1 - 1.3 9.0 44.7 0.83 9.7 6.3 5.8 2 2 4 6 6 6 0 Fibrinogen alpha/beta chain family Tweety PF04906.8 CCF44733.1 - 4.6 5.5 6.9 9.9 4.4 0.3 3.2 2 1 0 3 3 3 0 Tweety IncA PF04156.9 CCF44733.1 - 8.7 5.8 81.8 0.53 9.8 16.8 5.0 2 2 2 4 4 4 0 IncA protein Hexokinase_2 PF03727.11 CCF44734.1 - 3.8e-19 68.8 0.0 6e-19 68.2 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 CCF44734.1 - 7.6e-15 54.7 0.0 6.8e-14 51.6 0.0 2.1 1 1 0 1 1 1 1 Hexokinase Beta-lactamase PF00144.19 CCF44736.1 - 6.7e-28 97.6 1.4 9.2e-28 97.2 1.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Per1 PF04080.8 CCF44738.1 - 1.2e-105 352.8 4.5 1.4e-105 352.5 3.1 1.0 1 0 0 1 1 1 1 Per1-like DUF1772 PF08592.6 CCF44739.1 - 0.016 14.9 0.8 0.039 13.6 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) ATP-synt_B PF00430.13 CCF44739.1 - 0.62 9.8 8.6 1 9.1 5.9 1.2 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Methyltransf_23 PF13489.1 CCF44740.1 - 6e-18 65.0 0.0 9.5e-18 64.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF44740.1 - 7e-10 38.6 0.0 5e-09 35.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF44740.1 - 1.1e-08 35.4 0.0 2.3e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF44740.1 - 2.2e-08 34.6 0.0 5.8e-07 30.0 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF44740.1 - 1.8e-07 31.5 0.0 8.4e-07 29.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF44740.1 - 0.0019 18.4 0.0 0.0062 16.8 0.0 1.9 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF44740.1 - 0.0024 16.9 0.1 0.017 14.1 0.0 2.2 2 1 0 2 2 2 1 Putative methyltransferase Methyltransf_16 PF10294.4 CCF44740.1 - 0.04 13.3 0.0 0.07 12.5 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase FtsJ PF01728.14 CCF44740.1 - 0.041 13.8 0.0 0.083 12.8 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_2 PF00891.13 CCF44740.1 - 0.047 12.8 0.0 0.12 11.4 0.0 1.8 2 1 0 2 2 2 0 O-methyltransferase PCMT PF01135.14 CCF44740.1 - 0.063 12.8 0.0 0.67 9.4 0.0 2.1 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_26 PF13659.1 CCF44740.1 - 0.065 13.2 0.0 0.18 11.8 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 CCF44740.1 - 0.13 11.5 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.1 CCF44741.1 - 1.7e-19 70.1 0.0 2.5e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF44741.1 - 1e-12 47.8 0.0 3.2e-12 46.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF44741.1 - 6.4e-12 46.0 0.0 5e-11 43.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF44741.1 - 7.5e-09 35.9 0.0 1.3e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF44741.1 - 5e-08 33.3 0.0 2.5e-07 31.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF44741.1 - 1.1e-06 28.8 0.0 8.6e-06 26.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.15 CCF44741.1 - 0.0058 15.7 0.0 0.026 13.6 0.0 1.8 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_26 PF13659.1 CCF44741.1 - 0.0063 16.5 0.0 0.032 14.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF44741.1 - 0.0085 15.1 0.0 0.053 12.5 0.0 2.0 2 0 0 2 2 2 1 Putative methyltransferase FtsJ PF01728.14 CCF44741.1 - 0.014 15.3 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_16 PF10294.4 CCF44741.1 - 0.035 13.5 0.0 0.061 12.7 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_2 PF00891.13 CCF44741.1 - 0.035 13.2 0.0 0.06 12.5 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase MTS PF05175.9 CCF44741.1 - 0.045 13.1 0.0 0.12 11.7 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain PrmA PF06325.8 CCF44741.1 - 0.05 12.7 0.0 0.075 12.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.14 CCF44741.1 - 0.15 11.5 0.0 0.95 8.9 0.0 2.0 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.13 CCF44741.1 - 0.16 11.0 0.0 1.2 8.2 0.0 2.0 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family LysM PF01476.15 CCF44743.1 - 4.7e-07 29.5 0.0 6.6e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 LysM domain ATG22 PF11700.3 CCF44744.1 - 0.00039 19.0 0.0 0.00042 18.9 0.0 1.1 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.11 CCF44744.1 - 0.0021 16.8 1.2 0.0049 15.6 0.9 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily BDV_G PF06208.6 CCF44744.1 - 0.017 14.0 0.0 0.023 13.6 0.0 1.1 1 0 0 1 1 1 0 Borna disease virus G protein eIF-5a PF01287.15 CCF44746.1 - 3.6e-06 26.8 0.0 6.5e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold SNF PF00209.13 CCF44748.1 - 1.1e-22 80.2 11.4 1.1e-22 80.2 7.9 1.7 2 0 0 2 2 2 1 Sodium:neurotransmitter symporter family AviRa PF11599.3 CCF44753.1 - 0.12 11.3 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Vps23_core PF09454.5 CCF44754.1 - 2.2e-23 81.6 0.0 3e-23 81.2 0.0 1.2 1 0 0 1 1 1 1 Vps23 core domain Cas_NE0113 PF09623.5 CCF44754.1 - 0.063 12.7 0.0 0.15 11.5 0.0 1.5 2 0 0 2 2 2 0 CRISPR-associated protein NE0113 (Cas_NE0113) DUF1996 PF09362.5 CCF44755.1 - 5e-84 281.6 0.0 7.1e-84 281.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) WSC PF01822.14 CCF44755.1 - 1.3e-22 79.5 7.0 1.3e-22 79.5 4.8 2.4 3 0 0 3 3 3 1 WSC domain Rad21_Rec8 PF04824.11 CCF44757.1 - 3.1e-05 23.0 0.0 7.2e-05 21.8 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein zf-RING_2 PF13639.1 CCF44758.1 - 1.3e-12 47.3 6.9 2e-12 46.7 4.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 CCF44758.1 - 5.1e-08 32.9 3.3 1e-07 31.9 2.3 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 CCF44758.1 - 8.5e-08 31.7 4.2 1.3e-07 31.0 2.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF44758.1 - 2e-05 24.2 4.0 3e-05 23.6 2.8 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CCF44758.1 - 3.9e-05 23.5 5.9 6.2e-05 22.9 4.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF44758.1 - 0.0001 21.8 2.6 0.00015 21.3 1.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CCF44758.1 - 0.0014 18.4 1.7 0.0027 17.5 1.2 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 CCF44758.1 - 0.0081 15.7 6.4 0.013 15.0 4.5 1.3 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain PHD PF00628.24 CCF44758.1 - 0.14 11.8 5.7 0.24 11.1 3.9 1.4 1 0 0 1 1 1 0 PHD-finger FANCL_C PF11793.3 CCF44758.1 - 0.38 10.7 3.2 0.95 9.4 2.2 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.1 CCF44758.1 - 0.63 9.9 4.9 1.2 9.0 3.4 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.2 CCF44758.1 - 1.8 8.6 5.7 3.2 7.8 3.9 1.4 1 0 0 1 1 1 0 RING-variant domain Prok-RING_1 PF14446.1 CCF44758.1 - 3.9 7.2 8.5 3.5 7.4 3.9 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 Pyr_redox_3 PF13738.1 CCF44760.1 - 6.4e-21 75.3 0.0 1.3e-19 71.0 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF44760.1 - 1e-05 24.6 0.5 0.002 17.1 0.1 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Shikimate_DH PF01488.15 CCF44760.1 - 0.00049 20.2 0.0 0.0013 18.7 0.0 1.7 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 CCF44760.1 - 0.001 18.2 0.0 0.0018 17.4 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FMO-like PF00743.14 CCF44760.1 - 0.025 12.7 0.1 0.21 9.7 0.0 2.0 2 0 0 2 2 2 0 Flavin-binding monooxygenase-like RasGAP PF00616.14 CCF44762.1 - 1.5e-46 158.6 0.1 2.1e-46 158.0 0.1 1.3 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase CAP PF00188.21 CCF44763.1 - 3.8e-08 33.8 3.0 4.8e-08 33.5 2.0 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family TPR_12 PF13424.1 CCF44764.1 - 3.3e-05 23.7 2.7 0.81 9.6 0.0 4.6 4 1 1 5 5 5 1 Tetratricopeptide repeat Apc3 PF12895.2 CCF44764.1 - 0.018 15.1 0.0 0.74 9.9 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.1 CCF44764.1 - 0.023 14.3 0.5 24 4.6 0.0 4.2 5 0 0 5 5 5 0 TPR repeat TPR_2 PF07719.12 CCF44764.1 - 0.028 14.3 4.8 0.77 9.8 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 CCF44764.1 - 0.073 12.7 0.3 1.3 8.7 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 CCF44764.1 - 0.98 10.2 11.6 2.1 9.2 0.1 5.2 4 2 2 6 6 6 0 Tetratricopeptide repeat MscS_porin PF12795.2 CCF44766.1 - 0.017 14.4 3.8 0.021 14.1 2.6 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain DUF4618 PF15397.1 CCF44766.1 - 0.12 11.7 0.5 0.16 11.2 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) COG2 PF06148.6 CCF44766.1 - 0.3 10.9 1.4 0.5 10.2 0.9 1.3 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Zn_clus PF00172.13 CCF44767.1 - 0.0061 16.4 8.2 0.012 15.4 5.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SPX PF03105.14 CCF44768.1 - 5e-19 69.1 8.2 2.4e-12 47.2 0.2 3.3 1 1 2 3 3 3 2 SPX domain Chromate_transp PF02417.10 CCF44768.1 - 0.0012 18.4 0.8 0.0017 17.9 0.6 1.2 1 0 0 1 1 1 1 Chromate transporter DUF998 PF06197.8 CCF44768.1 - 0.0046 16.2 3.0 0.0074 15.6 2.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF998) Prefoldin_3 PF13758.1 CCF44768.1 - 0.13 12.0 0.9 0.68 9.7 0.3 2.5 2 1 0 2 2 2 0 Prefoldin subunit Epimerase PF01370.16 CCF44771.1 - 7.7e-08 32.0 0.0 0.00019 20.9 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 CCF44771.1 - 0.084 11.7 0.0 0.51 9.2 0.1 1.9 2 0 0 2 2 2 0 Male sterility protein NAD_binding_10 PF13460.1 CCF44771.1 - 0.11 12.4 0.1 0.4 10.6 0.1 2.1 1 1 0 1 1 1 0 NADH(P)-binding 3Beta_HSD PF01073.14 CCF44771.1 - 0.19 10.3 0.0 9.4 4.8 0.0 2.1 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family SH3_9 PF14604.1 CCF44772.1 - 1.9e-10 40.1 0.0 2.9e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 CCF44772.1 - 4.3e-06 26.0 0.0 6e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 CCF44772.1 - 3.5e-05 23.1 0.0 5.7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Peptidase_M24 PF00557.19 CCF44774.1 - 5.2e-46 156.8 0.1 6.3e-46 156.5 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-MYND PF01753.13 CCF44774.1 - 0.00049 19.9 3.7 0.00049 19.9 2.6 2.0 2 0 0 2 2 2 1 MYND finger DDE_1 PF03184.14 CCF44775.1 - 6e-28 97.4 0.0 8.6e-28 96.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 CCF44775.1 - 2e-09 37.1 0.0 5.2e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF44775.1 - 0.00068 19.1 0.0 0.0013 18.2 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain Pkinase PF00069.20 CCF44778.1 - 1.1e-32 113.1 0.0 1.4e-32 112.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF44778.1 - 1.4e-18 66.9 0.1 8.5e-18 64.3 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF44778.1 - 0.00012 21.1 0.0 0.00013 21.0 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CCF44778.1 - 0.0025 17.5 0.0 0.039 13.6 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 CCF44778.1 - 0.076 12.0 0.0 0.094 11.7 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Myosin_tail_1 PF01576.14 CCF44779.1 - 0.00013 19.8 2.0 0.00015 19.7 1.4 1.0 1 0 0 1 1 1 1 Myosin tail Cwf_Cwc_15 PF04889.7 CCF44779.1 - 0.012 15.3 1.8 0.012 15.3 1.3 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF1645 PF07816.6 CCF44779.1 - 0.033 14.6 2.7 0.037 14.4 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) Kelch_4 PF13418.1 CCF44782.1 - 4.5e-36 122.3 9.9 1.8e-09 37.1 0.4 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.20 CCF44782.1 - 3.9e-31 106.3 5.6 1.1e-12 47.2 0.2 6.5 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.1 CCF44782.1 - 7.7e-31 105.5 12.3 1.1e-08 34.9 0.1 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 CCF44782.1 - 4.6e-30 103.0 13.2 4.7e-08 32.8 0.1 6.9 7 0 0 7 7 7 6 Kelch motif Kelch_6 PF13964.1 CCF44782.1 - 2e-27 94.1 8.0 4.1e-11 42.5 0.5 6.4 5 1 1 6 6 6 6 Kelch motif Kelch_2 PF07646.10 CCF44782.1 - 3.1e-20 71.1 8.3 1.3e-07 31.0 0.2 6.6 6 0 0 6 6 6 5 Kelch motif Filament PF00038.16 CCF44782.1 - 0.0012 18.3 32.1 0.0012 18.3 22.3 3.9 2 1 2 4 4 4 2 Intermediate filament protein DUF4200 PF13863.1 CCF44782.1 - 0.0023 17.8 14.8 0.0023 17.8 10.2 6.5 5 1 1 6 6 6 2 Domain of unknown function (DUF4200) RAG2 PF03089.9 CCF44782.1 - 0.031 12.9 0.5 0.97 8.0 0.0 3.3 4 0 0 4 4 4 0 Recombination activating protein 2 Git3 PF11710.3 CCF44783.1 - 0.0011 18.5 0.0 0.0023 17.5 0.0 1.5 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.16 CCF44783.1 - 0.0063 15.6 0.1 0.0093 15.1 0.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) WD40 PF00400.27 CCF44784.1 - 3.9e-22 77.2 0.1 4.4e-07 29.5 0.1 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat P34-Arc PF04045.9 CCF44785.1 - 5.3e-65 219.0 0.0 6.8e-65 218.7 0.0 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Metallophos PF00149.23 CCF44786.1 - 0.0026 17.1 0.0 0.0034 16.7 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_53 PF07745.8 CCF44787.1 - 6e-54 183.0 0.0 1.2e-45 155.8 0.0 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 53 Aminotran_1_2 PF00155.16 CCF44788.1 - 4.4e-35 121.3 0.0 5.2e-35 121.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II VWA PF00092.23 CCF44789.1 - 4.4e-08 33.0 0.0 7.8e-07 28.9 0.0 2.1 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.1 CCF44789.1 - 2.5e-07 30.9 0.0 2.7e-06 27.5 0.0 2.3 1 1 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.4 CCF44789.1 - 3.7e-06 26.9 0.0 5.5e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus RTC4 PF14474.1 CCF44789.1 - 0.19 11.6 0.5 0.38 10.7 0.0 1.7 2 0 0 2 2 2 0 RTC4-like domain TFIIA PF03153.8 CCF44790.1 - 0.22 11.3 8.4 0.25 11.1 5.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit bZIP_2 PF07716.10 CCF44791.1 - 3.3e-12 46.0 12.1 5.3e-12 45.3 8.4 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.16 CCF44791.1 - 9.4e-05 22.2 12.4 9.4e-05 22.2 8.6 1.6 1 1 1 2 2 2 2 bZIP transcription factor FTZ PF03867.9 CCF44791.1 - 0.024 13.8 0.6 0.034 13.3 0.4 1.4 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region bZIP_Maf PF03131.12 CCF44791.1 - 0.051 13.8 6.8 0.099 12.9 4.7 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor RCR PF12273.3 CCF44791.1 - 0.065 13.7 2.5 0.12 12.9 1.8 1.4 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red IncA PF04156.9 CCF44791.1 - 0.067 12.7 4.2 0.089 12.3 2.9 1.1 1 0 0 1 1 1 0 IncA protein TSC22 PF01166.13 CCF44791.1 - 0.07 13.1 1.5 0.13 12.2 1.0 1.6 1 0 0 1 1 1 0 TSC-22/dip/bun family PGC7_Stella PF15549.1 CCF44791.1 - 0.17 11.8 5.8 0.086 12.8 2.3 1.7 1 1 0 1 1 1 0 PGC7/Stella/Dppa3 domain Phlebovirus_NSM PF07246.6 CCF44791.1 - 0.29 10.2 3.8 0.35 10.0 2.6 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M XhlA PF10779.4 CCF44791.1 - 0.3 11.0 4.5 0.52 10.2 3.1 1.5 1 1 0 1 1 1 0 Haemolysin XhlA Fzo_mitofusin PF04799.8 CCF44791.1 - 0.31 10.4 2.6 0.43 9.9 1.8 1.1 1 0 0 1 1 1 0 fzo-like conserved region DUF342 PF03961.8 CCF44791.1 - 0.37 9.1 4.8 0.43 8.9 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) V_ATPase_I PF01496.14 CCF44791.1 - 1 7.1 5.0 1.1 7.0 3.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF972 PF06156.8 CCF44791.1 - 1.5 9.2 8.9 0.52 10.6 3.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) U1snRNP70_N PF12220.3 CCF44791.1 - 3.9 7.8 7.2 0.91 9.8 1.6 2.2 1 1 1 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Reo_sigmaC PF04582.7 CCF44794.1 - 0.032 13.4 2.0 0.056 12.6 1.4 1.4 1 0 0 1 1 1 0 Reovirus sigma C capsid protein HHH_5 PF14520.1 CCF44794.1 - 0.095 12.8 0.1 0.24 11.5 0.1 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain Cob_adeno_trans PF01923.13 CCF44794.1 - 0.11 12.3 2.0 0.18 11.5 0.2 2.0 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Baculo_PEP_C PF04513.7 CCF44794.1 - 0.28 11.0 2.3 1.4 8.7 1.2 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1451 PF07295.6 CCF44794.1 - 0.76 9.5 6.4 0.21 11.3 1.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1451) Phage_lysis PF03245.8 CCF44794.1 - 1.2 9.0 6.2 17 5.3 0.1 2.9 2 1 0 2 2 2 0 Bacteriophage Rz lysis protein ING PF12998.2 CCF44794.1 - 4.6 7.5 10.2 3.7 7.8 1.5 2.9 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding HALZ PF02183.13 CCF44794.1 - 5.6 6.7 8.0 1.5 8.5 0.2 3.8 4 1 1 5 5 5 0 Homeobox associated leucine zipper DUF1664 PF07889.7 CCF44794.1 - 9.1 6.0 6.6 3.9 7.2 2.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) zf-C2H2_jaz PF12171.3 CCF44795.1 - 4.6e-07 29.7 0.1 7.9e-07 29.0 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CCF44795.1 - 4.4e-05 23.5 0.1 7.6e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type DUF1777 PF08648.7 CCF44795.1 - 0.00034 20.3 10.7 0.00034 20.3 7.4 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1777) zf-C2H2_2 PF12756.2 CCF44795.1 - 0.038 14.0 0.0 0.074 13.1 0.0 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-DBF PF07535.7 CCF44795.1 - 0.039 13.6 0.0 0.075 12.7 0.0 1.4 1 0 0 1 1 1 0 DBF zinc finger zf-C2H2 PF00096.21 CCF44795.1 - 0.079 13.3 0.5 0.13 12.6 0.3 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type UQ_con PF00179.21 CCF44796.1 - 2e-36 124.4 0.0 2.4e-36 124.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CCF44796.1 - 0.00013 21.6 0.1 0.00027 20.6 0.0 1.5 1 1 0 1 1 1 1 Prokaryotic E2 family B TRP PF06011.7 CCF44797.1 - 1.2e-118 396.5 20.3 1.5e-118 396.1 14.1 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 CCF44797.1 - 2.2e-38 131.4 3.9 4e-38 130.6 2.7 1.4 1 0 0 1 1 1 1 ML-like domain DUF3753 PF12575.3 CCF44797.1 - 3.7 7.4 7.7 1.8 8.4 0.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3753) Methyltransf_23 PF13489.1 CCF44798.1 - 0.0027 17.4 0.0 0.0035 17.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF44798.1 - 0.033 14.7 0.0 0.062 13.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain ADH_zinc_N PF00107.21 CCF44799.1 - 4.5e-24 84.4 0.5 5.5e-24 84.1 0.4 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF44799.1 - 0.00016 22.6 0.3 0.00021 22.1 0.2 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF359 PF04019.7 CCF44799.1 - 0.018 14.4 0.1 0.029 13.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF359) CoA_binding PF02629.14 CCF44799.1 - 0.37 11.3 3.4 0.48 10.9 0.5 2.4 3 1 0 3 3 3 0 CoA binding domain UBA PF00627.26 CCF44800.1 - 1.6e-10 40.4 0.4 3.1e-10 39.5 0.2 1.5 1 0 0 1 1 1 1 UBA/TS-N domain XPC-binding PF09280.6 CCF44800.1 - 9e-09 34.6 0.6 1.5e-08 33.9 0.4 1.4 1 0 0 1 1 1 1 XPC-binding domain eIF-5a PF01287.15 CCF44800.1 - 0.016 15.1 0.0 0.026 14.4 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold DUF3113 PF11310.3 CCF44800.1 - 0.027 14.1 1.0 3.8 7.2 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3113) MCM_N PF14551.1 CCF44800.1 - 0.034 14.6 0.0 0.034 14.6 0.0 1.2 1 0 0 1 1 1 0 MCM N-terminal domain Myb_DNA-binding PF00249.26 CCF44801.1 - 5.2e-07 29.6 0.0 1.1e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CCF44801.1 - 0.0033 17.4 0.0 0.016 15.2 0.0 2.1 1 1 1 2 2 2 1 Myb-like DNA-binding domain MARVEL PF01284.18 CCF44802.1 - 0.15 11.9 17.3 1.1 9.0 12.0 2.0 1 1 0 1 1 1 0 Membrane-associating domain Zn_clus PF00172.13 CCF44803.1 - 4.1e-09 36.2 9.5 6.3e-09 35.5 6.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF44803.1 - 7.6e-06 24.9 0.1 1.9e-05 23.7 0.1 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain RrnaAD PF00398.15 CCF44804.1 - 2.9e-52 177.3 0.0 3.6e-52 176.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 CCF44804.1 - 8.8e-09 35.4 0.0 1.6e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF44804.1 - 5.1e-07 30.2 0.0 1.1e-06 29.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 CCF44804.1 - 0.00012 21.6 0.0 0.00019 21.0 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 CCF44804.1 - 0.00024 20.7 0.0 0.00039 20.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF44804.1 - 0.00026 20.7 0.0 0.00049 19.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 CCF44804.1 - 0.00049 19.2 0.0 0.00073 18.6 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.9 CCF44804.1 - 0.0018 17.6 0.0 0.0033 16.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.7 CCF44804.1 - 0.0049 17.3 0.0 0.013 15.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF44804.1 - 0.013 14.5 0.0 0.027 13.5 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase NodS PF05401.6 CCF44804.1 - 0.026 13.9 0.0 0.46 9.8 0.0 2.2 2 0 0 2 2 2 0 Nodulation protein S (NodS) Methyltransf_11 PF08241.7 CCF44804.1 - 0.032 14.7 0.0 0.07 13.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.13 CCF44804.1 - 0.038 13.5 0.0 0.11 12.1 0.0 1.7 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Ubie_methyltran PF01209.13 CCF44804.1 - 0.043 12.9 0.0 0.073 12.1 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Nop53 PF07767.6 CCF44804.1 - 0.065 12.2 2.2 0.095 11.6 1.5 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Sigma70_ner PF04546.8 CCF44804.1 - 0.13 11.8 3.4 0.2 11.2 2.4 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region PUF PF00806.14 CCF44806.1 - 6.8e-26 88.2 0.0 3.3e-05 23.1 0.0 5.6 5 0 0 5 5 5 5 Pumilio-family RNA binding repeat RRM_1 PF00076.17 CCF44806.1 - 8.3e-13 47.7 0.0 1.7e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF44806.1 - 1.2e-06 28.1 0.0 2.5e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF44806.1 - 2.7e-06 27.2 0.0 6.3e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) HAD_2 PF13419.1 CCF44807.1 - 8.4e-30 104.2 0.0 1.1e-29 103.9 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase cEGF PF12662.2 CCF44809.1 - 0.048 13.2 0.4 0.11 12.2 0.3 1.7 1 0 0 1 1 1 0 Complement Clr-like EGF-like PEMT PF04191.8 CCF44810.1 - 1.9e-48 162.9 10.9 2.4e-26 91.8 1.4 2.9 2 0 0 2 2 2 2 Phospholipid methyltransferase DAO PF01266.19 CCF44811.1 - 0.0037 16.2 0.0 0.11 11.3 0.0 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Amino_oxidase PF01593.19 CCF44811.1 - 0.0039 16.3 0.1 0.2 10.6 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase OPT PF03169.10 CCF44813.1 - 1.2e-25 90.0 7.9 1.3e-25 89.9 5.5 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein MFS_1 PF07690.11 CCF44814.1 - 0.058 12.0 0.0 0.068 11.8 0.0 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily BsuPI PF12690.2 CCF44814.1 - 0.093 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Intracellular proteinase inhibitor DDE_1 PF03184.14 CCF44815.1 - 1.8e-34 118.8 0.0 2.9e-34 118.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 CCF44815.1 - 1.7e-12 46.9 0.2 8.8e-12 44.6 0.0 2.1 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF44815.1 - 5.1e-10 38.7 0.0 9.6e-10 37.8 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain MFS_1 PF07690.11 CCF44816.1 - 1.8e-34 119.0 27.5 1.2e-33 116.3 19.0 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF44816.1 - 1.4e-16 59.8 8.1 1.7e-16 59.5 5.6 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 CCF44816.1 - 2.1e-07 29.9 15.5 2.1e-07 29.9 10.7 1.7 2 0 0 2 2 2 1 Sugar (and other) transporter UNC-93 PF05978.11 CCF44816.1 - 0.054 12.9 5.3 0.095 12.1 3.7 1.5 1 0 0 1 1 1 0 Ion channel regulatory protein UNC-93 UQ_con PF00179.21 CCF44818.1 - 1.9e-26 92.1 0.1 2.6e-26 91.6 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CCF44818.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B MFS_1 PF07690.11 CCF44819.1 - 1.1e-24 86.8 32.4 1.1e-24 86.8 22.5 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF44819.1 - 4e-09 35.5 10.3 1.7e-07 30.2 1.1 3.5 2 2 1 3 3 3 2 Sugar (and other) transporter HET PF06985.6 CCF44820.1 - 1.4e-24 86.8 0.0 2.5e-24 86.0 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Aldo_ket_red PF00248.16 CCF44821.1 - 7.1e-48 162.8 0.0 9.2e-48 162.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family XH PF03469.9 CCF44821.1 - 0.066 12.8 0.1 0.066 12.8 0.1 2.1 3 0 0 3 3 3 0 XH domain Zn_clus PF00172.13 CCF44823.1 - 4.5e-09 36.0 13.6 6.7e-09 35.5 9.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mito_fiss_reg PF05308.6 CCF44823.1 - 2.3 7.4 9.1 0.39 10.0 3.3 1.9 2 0 0 2 2 2 0 Mitochondrial fission regulator RF-1 PF00472.15 CCF44824.1 - 2.6e-10 40.0 0.0 3.5e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 RF-1 domain MFS_1 PF07690.11 CCF44826.1 - 4.4e-20 71.7 13.3 6e-20 71.2 9.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF44826.1 - 0.02 13.0 0.3 0.028 12.6 0.2 1.1 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) DUF92 PF01940.11 CCF44826.1 - 0.03 13.4 0.7 0.053 12.6 0.5 1.3 1 0 0 1 1 1 0 Integral membrane protein DUF92 Fungal_trans PF04082.13 CCF44827.1 - 2.3e-20 72.5 0.0 3.6e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF44827.1 - 4.3e-09 36.1 9.7 8.5e-09 35.1 6.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DIE2_ALG10 PF04922.7 CCF44828.1 - 3.4e-68 230.4 14.3 6.3e-54 183.4 0.9 3.4 3 1 0 3 3 3 3 DIE2/ALG10 family Pkinase PF00069.20 CCF44829.1 - 1.1e-15 57.5 0.0 3.3e-15 55.9 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF44829.1 - 2.7e-09 36.5 0.0 2.8e-08 33.1 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Aminotran_4 PF01063.14 CCF44830.1 - 2.1e-30 105.9 0.0 2.8e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV ESSS PF10183.4 CCF44831.1 - 1.3e-24 86.5 0.2 1.6e-24 86.3 0.1 1.0 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) AAA_12 PF13087.1 CCF44832.1 - 2.9e-52 176.9 0.0 5.6e-52 176.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 CCF44832.1 - 3.3e-41 141.4 0.2 6.7e-21 74.9 0.0 2.5 1 1 1 2 2 2 2 AAA domain Dna2 PF08696.6 CCF44832.1 - 4.2e-14 52.3 0.3 5.4e-12 45.4 0.0 2.6 2 0 0 2 2 2 1 DNA replication factor Dna2 AAA_30 PF13604.1 CCF44832.1 - 5.2e-13 49.0 0.0 1.9e-12 47.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CCF44832.1 - 1.3e-11 44.0 0.2 3.1e-11 42.8 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain Cas_Cas4 PF01930.12 CCF44832.1 - 1.1e-08 35.1 0.1 2.1e-08 34.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF83 Viral_helicase1 PF01443.13 CCF44832.1 - 2.7e-08 33.6 0.3 0.12 11.8 0.0 3.4 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.9 CCF44832.1 - 4.8e-05 23.0 0.0 0.00015 21.4 0.0 1.9 1 1 0 1 1 1 1 Helicase UvrD-helicase PF00580.16 CCF44832.1 - 0.00031 20.1 0.2 0.00078 18.8 0.0 1.8 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain SRP54 PF00448.17 CCF44832.1 - 0.00047 19.6 0.1 0.00093 18.6 0.1 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain PIF1 PF05970.9 CCF44832.1 - 0.00049 19.1 0.1 0.0038 16.2 0.0 2.0 1 1 0 1 1 1 1 PIF1-like helicase CbiA PF01656.18 CCF44832.1 - 0.00059 19.3 0.0 0.0017 17.8 0.0 1.7 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.9 CCF44832.1 - 0.00064 19.4 0.3 0.0023 17.6 0.2 2.0 2 0 0 2 2 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 CCF44832.1 - 0.003 17.5 0.0 0.0068 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 CCF44832.1 - 0.005 16.2 0.0 0.05 12.9 0.0 2.5 3 0 0 3 3 3 1 AAA domain DUF2075 PF09848.4 CCF44832.1 - 0.0066 15.4 0.0 0.015 14.2 0.0 1.7 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) DUF87 PF01935.12 CCF44832.1 - 0.025 14.4 0.2 0.054 13.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF87 ArgK PF03308.11 CCF44832.1 - 0.032 13.0 0.6 0.13 11.0 0.0 2.0 2 0 0 2 2 2 0 ArgK protein AAA_10 PF12846.2 CCF44832.1 - 0.035 13.5 0.0 0.064 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain NTPase_1 PF03266.10 CCF44832.1 - 0.039 13.6 0.1 0.13 11.9 0.1 1.9 1 0 0 1 1 1 0 NTPase AAA_22 PF13401.1 CCF44832.1 - 0.043 13.9 0.1 0.16 12.1 0.0 2.1 1 1 0 1 1 1 0 AAA domain T2SE PF00437.15 CCF44832.1 - 0.046 12.6 0.0 0.12 11.2 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 CCF44832.1 - 0.047 13.1 0.1 0.16 11.4 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_33 PF13671.1 CCF44832.1 - 0.079 12.8 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 CCF44832.1 - 0.079 12.3 0.2 0.22 10.9 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TrwB_AAD_bind PF10412.4 CCF44832.1 - 0.08 11.5 0.1 0.47 9.0 0.1 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_5 PF07728.9 CCF44832.1 - 0.081 12.6 0.1 0.36 10.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA PF00004.24 CCF44832.1 - 0.087 13.0 0.1 0.19 11.9 0.1 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) P3A PF08727.6 CCF44833.1 - 0.79 9.1 2.7 0.62 9.4 0.3 1.8 2 0 0 2 2 2 0 Poliovirus 3A protein like CAS_CSE1 PF03378.10 CCF44834.1 - 1.2e-154 514.8 0.2 1.3e-154 514.6 0.2 1.0 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus UME PF08064.8 CCF44834.1 - 0.052 13.5 0.6 0.36 10.8 0.0 2.5 2 1 0 2 2 2 0 UME (NUC010) domain CBFD_NFYB_HMF PF00808.18 CCF44835.1 - 5.7e-05 23.1 0.1 7e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Prefoldin_2 PF01920.15 CCF44836.1 - 1.1e-24 86.1 9.6 1.1e-24 86.1 6.6 1.4 2 0 0 2 2 2 1 Prefoldin subunit PilJ PF13675.1 CCF44836.1 - 0.054 13.8 1.5 0.45 10.8 1.0 2.0 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term Fib_alpha PF08702.5 CCF44836.1 - 0.055 13.6 3.8 0.095 12.8 2.2 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.7 CCF44836.1 - 0.085 12.6 0.6 0.14 11.9 0.1 1.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Atg14 PF10186.4 CCF44836.1 - 0.14 11.0 3.1 0.19 10.6 2.1 1.3 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 AAA_23 PF13476.1 CCF44836.1 - 0.15 12.3 7.8 0.19 12.0 5.4 1.1 1 0 0 1 1 1 0 AAA domain DUF3496 PF12001.3 CCF44836.1 - 0.29 11.3 7.1 0.17 12.1 1.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3496) DUF1664 PF07889.7 CCF44836.1 - 0.34 10.6 0.1 0.34 10.6 0.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.6 CCF44836.1 - 0.46 10.4 8.1 0.3 10.9 1.0 2.6 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF1319 PF07028.6 CCF44836.1 - 0.59 10.3 9.4 0.48 10.6 2.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) Prefoldin PF02996.12 CCF44836.1 - 0.82 9.3 7.7 0.25 10.9 1.9 2.1 1 1 1 2 2 2 0 Prefoldin subunit MtrG PF04210.8 CCF44836.1 - 1.1 8.9 3.6 0.85 9.3 0.1 2.2 2 1 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G DUF2730 PF10805.3 CCF44836.1 - 1.1 8.9 6.0 1.2 8.8 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2730) bZIP_1 PF00170.16 CCF44836.1 - 1.3 9.0 9.7 0.12 12.3 0.9 2.2 2 0 0 2 2 2 0 bZIP transcription factor DUF972 PF06156.8 CCF44836.1 - 1.6 9.0 6.1 0.69 10.2 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Seryl_tRNA_N PF02403.17 CCF44836.1 - 4 7.5 12.1 1.1 9.3 0.2 2.5 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain GvpK PF05121.7 CCF44836.1 - 5.5 6.8 8.7 0.35 10.7 0.4 2.5 2 1 0 2 2 2 0 Gas vesicle protein K DivIC PF04977.10 CCF44836.1 - 5.6 6.5 10.2 5.9 6.4 0.2 2.2 2 0 0 2 2 2 0 Septum formation initiator XhlA PF10779.4 CCF44836.1 - 7.3 6.5 10.2 37 4.3 7.1 2.2 1 1 0 1 1 1 0 Haemolysin XhlA ORF6C PF10552.4 CCF44836.1 - 7.9 6.2 7.5 0.62 9.8 0.3 2.3 2 1 0 2 2 2 0 ORF6C domain Pectinesterase PF01095.14 CCF44837.1 - 9.8e-39 132.6 6.6 1.5e-38 132.0 4.6 1.2 1 0 0 1 1 1 1 Pectinesterase Pec_lyase_C PF00544.14 CCF44837.1 - 5.7e-19 68.3 3.9 6.8e-19 68.1 1.3 1.9 2 0 0 2 2 2 1 Pectate lyase Nucleoplasmin PF03066.10 CCF44837.1 - 0.027 13.9 3.0 0.05 13.1 2.0 1.4 1 0 0 1 1 1 0 Nucleoplasmin Ketoacyl-synt_C PF02801.17 CCF44838.1 - 4.1e-30 104.0 0.0 9.6e-30 102.8 0.0 1.6 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.16 CCF44838.1 - 2.8e-06 26.9 0.1 4.7e-06 26.1 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain ADH_N PF08240.7 CCF44839.1 - 1.1e-05 25.1 0.0 1.4e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain LigB PF02900.13 CCF44840.1 - 5.7e-45 153.4 0.0 7.2e-45 153.0 0.0 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Taeniidae_ag PF05596.6 CCF44840.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Taeniidae antigen B-block_TFIIIC PF04182.7 CCF44844.1 - 1.1e-13 50.8 0.0 2.1e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC DUF1610 PF07754.6 CCF44844.1 - 0.018 15.1 0.2 0.044 13.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1610) zf-TFIIB PF13453.1 CCF44844.1 - 0.027 13.6 0.0 0.058 12.5 0.0 1.5 1 0 0 1 1 1 0 Transcription factor zinc-finger Elf1 PF05129.8 CCF44844.1 - 0.054 13.1 1.8 0.12 12.0 1.3 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Fungal_trans PF04082.13 CCF44846.1 - 8.2e-27 93.7 0.7 8.2e-27 93.7 0.5 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zip PF02535.17 CCF44846.1 - 0.083 11.8 0.4 0.12 11.4 0.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Suf PF05843.9 CCF44846.1 - 0.33 10.6 6.7 0.54 9.9 4.6 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Ctr PF04145.10 CCF44846.1 - 0.54 10.3 3.3 3.2 7.8 1.4 2.4 2 0 0 2 2 2 0 Ctr copper transporter family Med15 PF09606.5 CCF44846.1 - 7.3 4.6 26.8 10 4.1 18.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal BBE PF08031.7 CCF44847.1 - 0.00028 20.7 0.1 0.0004 20.2 0.1 1.2 1 0 0 1 1 1 1 Berberine and berberine like Sterol-sensing PF12349.3 CCF44849.1 - 4.7e-13 48.8 5.9 3.5e-11 42.8 4.1 2.5 1 1 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.13 CCF44849.1 - 2.5e-06 25.7 0.7 3.7e-06 25.1 0.5 1.2 1 0 0 1 1 1 1 Patched family Lig_chan PF00060.21 CCF44849.1 - 0.00043 20.0 1.6 0.43 10.2 0.0 2.3 2 0 0 2 2 2 2 Ligand-gated ion channel MFS_1 PF07690.11 CCF44850.1 - 4.5e-45 153.9 34.3 8.9e-39 133.1 11.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF44850.1 - 1.2e-17 63.6 15.1 3.1e-17 62.3 10.5 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 CCF44850.1 - 6.3e-06 24.6 0.2 6.3e-06 24.6 0.1 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Folate_carrier PF01770.13 CCF44850.1 - 3.6e-05 22.4 0.0 6.2e-05 21.6 0.0 1.3 1 0 0 1 1 1 1 Reduced folate carrier OATP PF03137.15 CCF44850.1 - 0.0036 15.4 9.7 0.03 12.3 3.1 2.6 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Spt20 PF12090.3 CCF44850.1 - 0.024 14.0 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 Spt20 family PsiA PF06952.6 CCF44850.1 - 0.035 13.1 0.1 0.057 12.4 0.1 1.2 1 0 0 1 1 1 0 PsiA protein DUF1980 PF09323.5 CCF44850.1 - 0.39 10.4 2.3 3.5 7.3 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1980) ATP_synt_I PF03899.10 CCF44850.1 - 7 6.8 24.8 0.84 9.8 4.2 3.7 3 1 1 4 4 4 0 ATP synthase I chain V-ATPase_C PF03223.10 CCF44853.1 - 0.13 11.1 0.1 0.16 10.8 0.0 1.1 1 0 0 1 1 1 0 V-ATPase subunit C MerR-DNA-bind PF09278.6 CCF44853.1 - 1.2 9.6 10.9 1.8 9.0 7.6 1.3 1 0 0 1 1 1 0 MerR, DNA binding zf-C2H2_2 PF12756.2 CCF44855.1 - 2.1e-08 34.2 6.8 0.00032 20.7 0.6 2.5 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 CCF44855.1 - 0.00079 19.4 14.0 0.0063 16.6 1.5 3.1 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CCF44855.1 - 0.0076 16.4 7.7 0.24 11.6 0.3 3.1 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2 PF00096.21 CCF44855.1 - 0.012 15.8 0.4 0.012 15.8 0.3 3.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF44855.1 - 0.019 15.2 0.1 0.019 15.2 0.1 3.2 4 0 0 4 4 4 0 C2H2-type zinc finger LIM PF00412.17 CCF44855.1 - 0.034 14.1 1.7 1.1 9.3 0.1 3.1 2 0 0 2 2 2 0 LIM domain Evr1_Alr PF04777.8 CCF44855.1 - 0.1 12.5 3.1 3.2 7.7 0.1 2.5 1 1 1 2 2 2 0 Erv1 / Alr family UPF0004 PF00919.15 CCF44855.1 - 0.16 11.7 3.0 0.57 10.0 0.3 2.4 2 0 0 2 2 2 0 Uncharacterized protein family UPF0004 Arc_trans_TRASH PF08394.5 CCF44855.1 - 0.44 10.7 6.3 4.2 7.6 0.6 2.8 3 0 0 3 3 3 0 Archaeal TRASH domain Chordopox_A33R PF05966.7 CCF44855.1 - 0.52 9.0 4.2 0.13 10.9 0.9 1.5 2 0 0 2 2 2 0 Chordopoxvirus A33R protein NAD_kinase PF01513.16 CCF44857.1 - 1.2e-49 168.6 0.0 3.3e-49 167.2 0.0 1.6 1 1 0 1 1 1 1 ATP-NAD kinase Acyl_transf_1 PF00698.16 CCF44858.1 - 5e-65 219.9 0.1 8.5e-65 219.1 0.1 1.4 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.21 CCF44858.1 - 5.8e-61 206.1 0.0 1.5e-60 204.8 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.5 CCF44858.1 - 5.6e-58 195.5 1.7 6.3e-58 195.4 0.0 2.1 2 0 0 2 2 1 1 KR domain PS-DH PF14765.1 CCF44858.1 - 2.2e-54 184.6 0.0 4e-54 183.7 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.20 CCF44858.1 - 6.4e-47 159.5 0.1 2.4e-46 157.7 0.1 2.1 1 0 0 1 1 1 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 CCF44858.1 - 3.5e-31 107.5 3.5 4.6e-31 107.1 0.2 2.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N PF00107.21 CCF44858.1 - 1.2e-19 70.1 0.1 4.4e-19 68.3 0.1 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.7 CCF44858.1 - 1.1e-18 67.5 0.0 2.9e-18 66.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF44858.1 - 3.9e-14 52.6 0.0 1.3e-13 50.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.1 CCF44858.1 - 4.6e-14 53.4 0.0 5.4e-13 49.9 0.0 2.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF44858.1 - 3.1e-10 39.7 0.1 1.6e-09 37.5 0.0 2.2 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Methyltransf_31 PF13847.1 CCF44858.1 - 1.9e-09 37.2 0.0 5.8e-09 35.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF44858.1 - 4.9e-08 33.5 0.0 1.8e-07 31.7 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF44858.1 - 5.6e-07 29.9 0.0 1.8e-06 28.3 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF44858.1 - 0.00016 20.8 0.0 0.00036 19.7 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Thiolase_N PF00108.18 CCF44858.1 - 0.00032 19.7 1.0 0.0016 17.5 0.1 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain Methyltransf_25 PF13649.1 CCF44858.1 - 0.002 18.4 0.0 0.006 16.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.20 CCF44858.1 - 0.0055 16.9 0.0 0.017 15.3 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_16 PF10294.4 CCF44858.1 - 0.0057 16.1 0.0 0.013 14.9 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase DREV PF05219.7 CCF44858.1 - 0.027 13.3 0.0 0.052 12.4 0.0 1.4 1 0 0 1 1 1 0 DREV methyltransferase DUF3328 PF11807.3 CCF44859.1 - 1.8e-20 73.5 1.5 2.1e-20 73.3 1.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.3 CCF44860.1 - 0.023 14.3 1.3 0.034 13.8 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) PAP1 PF08601.5 CCF44860.1 - 0.047 13.3 0.0 0.062 12.9 0.0 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Thioesterase PF00975.15 CCF44861.1 - 4.5e-13 49.9 0.0 7.2e-13 49.2 0.0 1.5 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.2 CCF44861.1 - 4.4e-09 36.5 0.0 6e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 CCF44861.1 - 0.0016 18.0 0.0 0.0021 17.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF44861.1 - 0.0039 16.9 0.0 0.0051 16.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF44861.1 - 0.0057 16.2 0.0 0.0066 16.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF3328 PF11807.3 CCF44862.1 - 0.018 14.7 0.0 0.023 14.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) WD40 PF00400.27 CCF44863.1 - 0.026 14.4 1.9 0.86 9.5 0.0 2.9 4 0 0 4 4 4 0 WD domain, G-beta repeat MFS_1 PF07690.11 CCF44864.1 - 1.2e-10 40.6 20.3 1.7e-10 40.1 12.9 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF44864.1 - 7.1e-06 24.8 4.2 7.1e-06 24.8 2.9 1.6 2 0 0 2 2 2 1 Sugar (and other) transporter GTP_EFTU PF00009.22 CCF44865.1 - 5.6e-62 208.5 0.2 7e-62 208.2 0.2 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CCF44865.1 - 7.7e-06 25.8 0.2 1.6e-05 24.8 0.2 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.4 CCF44865.1 - 0.0034 16.8 0.6 0.017 14.5 0.1 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation GatB_N PF02934.10 CCF44867.1 - 1.2e-102 342.6 0.0 1.5e-102 342.3 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain Methyltransf_31 PF13847.1 CCF44870.1 - 6.4e-11 42.0 0.0 1e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 CCF44870.1 - 1.5e-10 40.7 0.0 2.3e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PRMT5 PF05185.11 CCF44870.1 - 2.6e-09 36.4 0.0 3.5e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_18 PF12847.2 CCF44870.1 - 7.9e-08 32.8 0.0 2.1e-07 31.5 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF44870.1 - 1.2e-07 31.7 0.0 3.3e-07 30.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF44870.1 - 1.3e-07 31.9 0.0 3.7e-07 30.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.6 CCF44870.1 - 2.4e-06 26.4 0.1 3.5e-06 25.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_25 PF13649.1 CCF44870.1 - 1.2e-05 25.5 0.0 5.9e-05 23.3 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF44870.1 - 0.00011 21.9 0.0 0.00026 20.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF44870.1 - 0.00074 19.9 0.0 0.0016 18.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF44870.1 - 0.0014 18.0 0.0 0.0021 17.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.15 CCF44870.1 - 0.0033 16.5 0.0 0.0046 16.0 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.1 CCF44870.1 - 0.066 12.8 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltrans_SAM PF10672.4 CCF44870.1 - 0.13 11.0 0.1 0.22 10.3 0.1 1.3 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase DUF1903 PF08991.5 CCF44871.1 - 1.4e-15 57.1 2.2 1.8e-15 56.8 1.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1903) CHCH PF06747.8 CCF44871.1 - 0.03 14.2 2.2 0.046 13.6 1.5 1.3 1 0 0 1 1 1 0 CHCH domain Cmc1 PF08583.5 CCF44871.1 - 0.046 13.5 1.6 0.07 12.9 1.1 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like UvrD_C_2 PF13538.1 CCF44871.1 - 0.075 13.1 0.0 0.075 13.1 0.0 1.1 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Nup84_Nup100 PF04121.8 CCF44873.1 - 6.6e-12 43.9 1.9 8.9e-12 43.5 1.3 1.1 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 ANTH PF07651.11 CCF44873.1 - 0.02 13.6 0.1 0.028 13.1 0.1 1.1 1 0 0 1 1 1 0 ANTH domain tRNA-synt_2 PF00152.15 CCF44874.1 - 5.2e-11 41.8 0.0 5.3e-11 41.8 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) Glyco_hydro_3 PF00933.16 CCF44875.1 - 4.1e-37 127.7 0.0 4.8e-37 127.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Abhydrolase_9_N PF15420.1 CCF44877.1 - 0.011 15.5 4.3 0.019 14.7 3.0 1.3 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus DUF4418 PF14387.1 CCF44877.1 - 0.63 9.7 11.4 0.75 9.5 3.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4418) Helicase_C PF00271.26 CCF44879.1 - 3.2e-29 100.5 0.0 5.9e-29 99.7 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.1 CCF44879.1 - 0.00028 20.8 0.0 0.00045 20.2 0.0 1.3 1 0 0 1 1 1 1 Helicase C-terminal domain DUF1253 PF06862.7 CCF44879.1 - 0.0083 14.5 0.0 0.01 14.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1253) DUF3734 PF12536.3 CCF44879.1 - 0.061 13.4 0.4 4.4 7.4 0.0 2.2 2 0 0 2 2 2 0 Patatin phospholipase FtsK_SpoIIIE PF01580.13 CCF44879.1 - 0.13 11.7 0.2 0.56 9.6 0.0 2.1 2 1 0 2 2 2 0 FtsK/SpoIIIE family API5 PF05918.6 CCF44879.1 - 5 5.4 7.9 7.2 4.9 5.5 1.3 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) DUF3628 PF12300.3 CCF44879.1 - 9.1 6.2 9.3 14 5.6 6.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3628) Melibiase PF02065.13 CCF44880.1 - 1.8e-17 63.1 0.0 1.9e-17 63.0 0.0 1.0 1 0 0 1 1 1 1 Melibiase Dak2 PF02734.12 CCF44881.1 - 6.1e-34 117.1 0.7 7.1e-34 116.9 0.5 1.0 1 0 0 1 1 1 1 DAK2 domain LSM PF01423.17 CCF44882.1 - 5.6e-18 64.2 0.1 7.5e-18 63.8 0.1 1.2 1 0 0 1 1 1 1 LSM domain Trp_DMAT PF11991.3 CCF44882.1 - 0.098 11.8 0.0 0.13 11.4 0.0 1.0 1 0 0 1 1 1 0 Tryptophan dimethylallyltransferase Alpha-amylase PF00128.19 CCF44884.1 - 1.3e-66 225.1 0.0 1.8e-66 224.7 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.6 CCF44884.1 - 4e-22 78.0 0.0 7e-22 77.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) Pyr_redox_3 PF13738.1 CCF44885.1 - 4.9e-25 88.7 0.0 2.1e-24 86.7 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF44885.1 - 6.1e-07 29.3 0.0 1.5e-05 24.9 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.14 CCF44885.1 - 4.6e-05 21.8 0.0 0.00028 19.2 0.0 1.9 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.1 CCF44885.1 - 4.7e-05 23.2 0.0 0.011 15.5 0.0 3.2 3 0 0 3 3 3 1 FAD-NAD(P)-binding K_oxygenase PF13434.1 CCF44885.1 - 9.7e-05 21.4 0.0 0.00057 18.8 0.0 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Shikimate_DH PF01488.15 CCF44885.1 - 0.00028 21.0 0.0 0.022 14.8 0.0 2.5 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.22 CCF44885.1 - 0.0091 16.3 0.0 6.5 7.2 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CCF44885.1 - 0.017 14.9 0.3 12 5.7 0.1 3.4 2 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.14 CCF44885.1 - 0.048 12.8 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ThiF PF00899.16 CCF44885.1 - 0.088 12.6 0.9 1.1 9.0 0.1 2.4 2 0 0 2 2 2 0 ThiF family FAD_binding_3 PF01494.14 CCF44885.1 - 0.093 11.7 0.2 0.9 8.5 0.1 2.3 2 0 0 2 2 2 0 FAD binding domain p450 PF00067.17 CCF44886.1 - 7.6e-54 182.9 0.0 9.6e-54 182.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 polyprenyl_synt PF00348.12 CCF44887.1 - 5.6e-34 117.1 0.0 9.8e-34 116.3 0.0 1.3 1 0 0 1 1 1 1 Polyprenyl synthetase Terpene_synth_C PF03936.11 CCF44887.1 - 2.6e-05 23.5 2.5 3.3e-05 23.2 0.7 1.9 2 0 0 2 2 2 1 Terpene synthase family, metal binding domain Sporozoite_P67 PF05642.6 CCF44887.1 - 0.2 9.5 2.6 0.27 9.0 1.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF947 PF06102.7 CCF44889.1 - 1.7e-55 187.3 26.7 1.7e-55 187.3 18.5 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF947) NIF PF03031.13 CCF44890.1 - 3e-10 40.0 0.0 3.7e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF1363 PF07101.6 CCF44890.1 - 0.064 13.3 0.0 0.077 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1363) Myosin_head PF00063.16 CCF44891.1 - 3.4e-45 154.3 0.0 4.3e-45 153.9 0.0 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) TRAPP PF04051.11 CCF44893.1 - 5.9e-44 149.2 0.0 7.1e-44 148.9 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Gly-zipper_OmpA PF13436.1 CCF44893.1 - 0.96 9.1 9.8 1.8 8.2 6.8 1.4 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Ldh_1_C PF02866.13 CCF44894.1 - 1.6e-13 50.7 0.0 1.8e-13 50.6 0.0 1.0 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Myosin_head PF00063.16 CCF44896.1 - 1.2e-199 664.8 1.3 2.1e-199 664.0 0.9 1.4 1 1 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.8 CCF44896.1 - 3.5e-27 95.0 0.0 1.3e-26 93.1 0.0 2.0 2 0 0 2 2 2 1 Myosin tail IQ PF00612.22 CCF44896.1 - 0.00056 19.3 9.7 0.024 14.2 1.7 2.7 1 1 1 2 2 2 2 IQ calmodulin-binding motif AAA_22 PF13401.1 CCF44896.1 - 0.0028 17.8 0.0 0.0082 16.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain Hpr_kinase_C PF07475.7 CCF44896.1 - 0.011 15.0 0.3 1.8 7.8 0.0 2.3 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain Zeta_toxin PF06414.7 CCF44896.1 - 0.015 14.3 0.1 0.041 12.9 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin AAA_17 PF13207.1 CCF44896.1 - 0.029 15.1 0.0 0.11 13.2 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CCF44896.1 - 0.035 14.4 0.0 0.11 12.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 CCF44896.1 - 0.048 13.3 0.0 0.18 11.4 0.0 2.0 2 0 0 2 2 2 0 NACHT domain DUF4145 PF13643.1 CCF44896.1 - 0.059 13.2 0.0 0.98 9.3 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4145) DUF552 PF04472.7 CCF44896.1 - 0.06 13.2 0.1 0.25 11.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF552) AAA_19 PF13245.1 CCF44896.1 - 0.079 12.7 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain ABC_tran PF00005.22 CCF44896.1 - 0.24 11.7 1.8 0.52 10.6 0.5 2.2 2 1 0 2 2 2 0 ABC transporter DUF2628 PF10947.3 CCF44897.1 - 0.16 11.8 1.5 0.31 10.8 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) Sec7_N PF12783.2 CCF44899.1 - 9.5e-52 174.8 3.6 1.8e-51 173.8 2.5 1.5 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal 2-oxoacid_dh PF00198.18 CCF44900.1 - 3.2e-74 249.1 0.0 4.1e-74 248.7 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 CCF44900.1 - 1.9e-18 65.8 0.6 5.2e-18 64.4 0.4 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 CCF44900.1 - 1.7e-08 33.9 1.9 1.7e-08 33.9 1.3 2.0 2 0 0 2 2 2 1 e3 binding domain Ribosomal_60s PF00428.14 CCF44900.1 - 0.039 14.3 13.0 0.17 12.2 4.1 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein UDPG_MGDP_dh_N PF03721.9 CCF44903.1 - 4.4e-30 104.4 0.0 7.1e-30 103.7 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Saccharop_dh PF03435.13 CCF44903.1 - 0.00083 18.4 0.0 0.00098 18.1 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase 3HCDH_N PF02737.13 CCF44903.1 - 0.0069 16.0 0.0 0.018 14.6 0.0 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.18 CCF44903.1 - 0.0074 16.0 0.0 4.4 7.0 0.0 2.4 2 0 0 2 2 2 2 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TrkA_N PF02254.13 CCF44903.1 - 0.025 14.5 0.4 0.83 9.6 0.0 2.8 3 1 0 3 3 3 0 TrkA-N domain Shikimate_DH PF01488.15 CCF44903.1 - 0.057 13.5 0.0 2.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Transketolase_N PF00456.16 CCF44904.1 - 4.1e-119 397.3 0.1 5e-119 397.0 0.1 1.0 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain E1_dh PF00676.15 CCF44904.1 - 7e-08 31.5 0.1 1e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 CCF44904.1 - 2e-07 30.2 0.0 5.8e-06 25.4 0.0 2.1 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase DUF2263 PF10021.4 CCF44906.1 - 6.3e-17 61.9 0.0 1.3e-16 60.9 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) TraG-D_C PF12696.2 CCF44906.1 - 0.39 10.5 2.9 0.65 9.8 2.0 1.3 1 0 0 1 1 1 0 TraM recognition site of TraD and TraG Candida_ALS PF05792.8 CCF44907.1 - 0.00038 20.5 14.0 0.00038 20.5 9.7 6.6 7 0 0 7 7 7 2 Candida agglutinin-like (ALS) MFS_1 PF07690.11 CCF44908.1 - 2.3e-19 69.3 26.0 3.7e-19 68.6 18.0 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 CCF44908.1 - 4.2e-12 45.8 5.1 4.2e-12 45.8 3.5 2.9 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.19 CCF44908.1 - 0.0011 17.5 8.8 0.0032 16.1 6.1 1.7 1 0 0 1 1 1 1 Sugar (and other) transporter PsaM PF07465.8 CCF44908.1 - 0.11 12.0 2.2 1.2 8.7 0.5 3.0 2 0 0 2 2 2 0 Photosystem I protein M (PsaM) DUF3021 PF11457.3 CCF44908.1 - 0.74 9.6 7.3 0.35 10.7 0.7 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3021) SdpI PF13630.1 CCF44908.1 - 2.7 7.7 10.0 2.5 7.8 0.5 3.4 3 0 0 3 3 3 0 SdpI/YhfL protein family MerC PF03203.9 CCF44908.1 - 8.3 6.8 8.2 1.9 8.8 1.8 2.8 3 0 0 3 3 3 0 MerC mercury resistance protein Amidohydro_4 PF13147.1 CCF44911.1 - 8.9e-12 45.6 0.2 2e-09 37.8 0.0 2.9 2 1 0 2 2 2 2 Amidohydrolase Amidohydro_1 PF01979.15 CCF44911.1 - 2e-08 34.2 0.0 1.5e-06 28.0 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.6 CCF44911.1 - 0.0002 20.6 0.0 0.00039 19.7 0.0 1.5 1 0 0 1 1 1 1 Amidohydrolase family tRNA_int_endo PF01974.12 CCF44911.1 - 0.058 13.2 0.0 5.3 6.9 0.0 3.2 3 0 0 3 3 3 0 tRNA intron endonuclease, catalytic C-terminal domain OPT PF03169.10 CCF44912.1 - 3.7e-101 339.4 18.3 4.6e-101 339.1 12.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Meth_synt_1 PF08267.7 CCF44913.1 - 1.3e-66 224.9 0.0 1.6e-66 224.7 0.0 1.0 1 0 0 1 1 1 1 Cobalamin-independent synthase, N-terminal domain SHS2_Rpb7-N PF03876.12 CCF44914.1 - 1.1e-06 28.6 0.0 1.8e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 MIP-T3 PF10243.4 CCF44914.1 - 0.0085 14.6 32.4 0.012 14.1 22.4 1.1 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 hNIFK_binding PF12196.3 CCF44914.1 - 0.77 9.1 5.2 3.7 7.0 0.4 2.8 2 0 0 2 2 2 0 FHA Ki67 binding domain of hNIFK SOBP PF15279.1 CCF44914.1 - 1.4 9.1 11.4 1.9 8.7 7.9 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein NmrA PF05368.8 CCF44915.1 - 2.8e-15 56.1 0.0 3.2e-15 56.0 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF44915.1 - 1.5e-09 38.0 0.1 1.9e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 CCF44915.1 - 9e-07 27.8 0.0 1e-06 27.7 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Saccharop_dh PF03435.13 CCF44915.1 - 1.4e-06 27.5 0.0 1.7e-06 27.3 0.0 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase Semialdhyde_dh PF01118.19 CCF44915.1 - 5.8e-05 23.3 0.0 6.8e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.16 CCF44915.1 - 0.00013 21.4 0.0 0.00015 21.2 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.20 CCF44915.1 - 0.00026 20.9 0.0 0.0003 20.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF44915.1 - 0.00027 20.6 0.0 0.00031 20.4 0.0 1.1 1 0 0 1 1 1 1 KR domain TrkA_N PF02254.13 CCF44915.1 - 0.00036 20.4 0.1 0.00046 20.1 0.0 1.1 1 0 0 1 1 1 1 TrkA-N domain Polysacc_synt_2 PF02719.10 CCF44915.1 - 0.066 12.0 0.0 0.078 11.8 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein dCMP_cyt_deam_1 PF00383.17 CCF44918.1 - 0.00047 19.7 0.0 0.0005 19.6 0.0 1.0 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region F-box PF00646.28 CCF44920.1 - 0.023 14.3 0.1 4.4 7.0 0.0 2.6 2 0 0 2 2 2 0 F-box domain bZIP_1 PF00170.16 CCF44920.1 - 0.14 12.1 0.4 0.26 11.2 0.3 1.4 1 0 0 1 1 1 0 bZIP transcription factor TFIIS_M PF07500.9 CCF44922.1 - 2.5e-29 101.6 0.6 5.5e-29 100.5 0.4 1.6 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.13 CCF44922.1 - 1.3e-18 66.2 5.9 2.3e-18 65.5 4.1 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.6 CCF44922.1 - 2.1e-14 52.7 0.2 4.1e-14 51.8 0.1 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain MbeB_N PF04837.7 CCF44922.1 - 0.81 9.8 5.1 10 6.2 0.1 2.8 2 0 0 2 2 2 0 MbeB-like, N-term conserved region ATP-synt_E PF05680.7 CCF44922.1 - 3.8 7.5 7.8 0.48 10.4 0.5 2.6 2 1 0 2 2 2 0 ATP synthase E chain Glyco_hydro_15 PF00723.16 CCF44923.1 - 2.5e-12 46.0 0.0 3.2e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 KRE9 PF05390.6 CCF44924.1 - 0.034 14.5 0.1 0.059 13.7 0.1 1.4 1 0 0 1 1 1 0 Yeast cell wall synthesis protein KRE9/KNH1 Fungal_trans_2 PF11951.3 CCF44930.1 - 3e-07 29.3 0.4 4.6e-05 22.2 0.1 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Epimerase PF01370.16 CCF44931.1 - 3.2e-37 128.2 0.0 4.7e-37 127.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Epimerase_Csub PF13950.1 CCF44931.1 - 4.5e-26 90.5 0.0 7.4e-26 89.8 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit 3Beta_HSD PF01073.14 CCF44931.1 - 4.1e-14 51.9 0.0 1.2e-13 50.3 0.0 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 CCF44931.1 - 1.2e-09 38.3 0.0 3.5e-08 33.5 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.1 CCF44931.1 - 1.8e-09 37.8 0.0 3.1e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 CCF44931.1 - 3.7e-07 29.3 0.0 0.00016 20.6 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.12 CCF44931.1 - 6.1e-07 28.6 0.0 1.1e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 CCF44931.1 - 2.5e-06 26.6 0.0 0.00036 19.5 0.0 2.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.5 CCF44931.1 - 4.8e-06 26.3 0.0 0.00011 21.9 0.0 2.1 2 0 0 2 2 2 1 KR domain UDPG_MGDP_dh_N PF03721.9 CCF44931.1 - 0.0037 16.6 0.1 0.0061 15.9 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NmrA PF05368.8 CCF44931.1 - 0.01 15.1 0.0 0.038 13.2 0.0 1.8 2 0 0 2 2 2 0 NmrA-like family ADH_zinc_N_2 PF13602.1 CCF44932.1 - 1.6e-09 38.7 0.0 1.7e-09 38.6 0.0 1.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Peptidase_S8 PF00082.17 CCF44933.1 - 1.3e-45 155.7 2.7 1.7e-45 155.3 1.8 1.1 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 CCF44933.1 - 0.005 17.3 0.0 0.013 16.0 0.0 1.7 1 0 0 1 1 1 1 Peptidase inhibitor I9 TauD PF02668.11 CCF44935.1 - 6e-27 94.9 0.0 8.7e-27 94.4 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF2205 PF10224.4 CCF44935.1 - 0.089 12.3 1.3 3.7 7.1 0.0 2.3 2 0 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) Zn_clus PF00172.13 CCF44937.1 - 2.6e-07 30.4 8.6 2.6e-07 30.4 5.9 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_6 PF12697.2 CCF44938.1 - 1.6e-15 57.6 0.4 2e-15 57.3 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF44938.1 - 5.2e-11 42.4 0.0 1.1e-10 41.4 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF44938.1 - 2.6e-10 40.2 0.0 4.6e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CCF44938.1 - 1.6e-06 27.5 0.0 2.7e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF1100 PF06500.6 CCF44938.1 - 1e-05 24.3 0.0 1.5e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Esterase PF00756.15 CCF44938.1 - 6e-05 22.5 0.1 0.0001 21.8 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.8 CCF44938.1 - 0.0016 18.0 0.0 0.0024 17.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2048 PF09752.4 CCF44938.1 - 0.018 13.9 0.1 0.027 13.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) Peptidase_S15 PF02129.13 CCF44938.1 - 0.023 14.0 0.2 0.034 13.5 0.1 1.4 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) AXE1 PF05448.7 CCF44938.1 - 0.072 11.5 0.1 0.24 9.8 0.1 1.7 1 1 1 2 2 2 0 Acetyl xylan esterase (AXE1) ADH_zinc_N PF00107.21 CCF44939.1 - 1e-06 28.3 0.0 1.6e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Mito_carr PF00153.22 CCF44940.1 - 2.2e-54 181.1 6.1 8.5e-21 73.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein SecE PF00584.15 CCF44940.1 - 0.036 13.6 0.0 0.087 12.4 0.0 1.6 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex Sugar_tr PF00083.19 CCF44941.1 - 2e-77 260.7 16.5 2.4e-77 260.4 11.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF44941.1 - 2e-23 82.7 23.3 1.1e-21 76.9 8.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CCF44941.1 - 1.5e-06 26.9 0.6 1.5e-06 26.9 0.4 3.1 2 1 1 3 3 3 1 MFS/sugar transport protein ATP_synt_H PF05493.8 CCF44941.1 - 7.1 6.7 12.1 4.8 7.3 3.5 3.2 2 0 0 2 2 2 0 ATP synthase subunit H JmjC PF02373.17 CCF44942.1 - 9.8e-36 122.4 0.5 9.8e-36 122.4 0.3 2.1 2 0 0 2 2 2 1 JmjC domain, hydroxylase zf-HC5HC2H PF13771.1 CCF44942.1 - 2.3e-21 75.7 4.9 2.3e-21 75.7 3.4 2.4 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.1 CCF44942.1 - 2.5e-21 75.7 4.3 4.8e-21 74.8 3.0 1.5 1 0 0 1 1 1 1 PHD-zinc-finger like domain JmjN PF02375.12 CCF44942.1 - 6.9e-13 47.8 0.9 1.4e-12 46.8 0.7 1.6 1 0 0 1 1 1 1 jmjN domain Peptidase_M1 PF01433.15 CCF44943.1 - 2.1e-133 445.1 3.4 2.9e-133 444.7 2.4 1.2 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 CCF44943.1 - 9.3e-75 251.8 0.0 1.5e-74 251.1 0.0 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 CCF44943.1 - 8.2e-21 74.3 1.2 8.2e-21 74.3 0.8 2.5 1 1 1 2 2 2 1 Peptidase MA superfamily DUF45 PF01863.12 CCF44943.1 - 0.0062 16.3 0.0 0.28 10.9 0.0 2.7 2 1 1 3 3 3 1 Protein of unknown function DUF45 HTH_psq PF05225.11 CCF44944.1 - 6e-12 44.9 0.0 1.2e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF44944.1 - 1.3e-11 44.1 0.1 8.2e-11 41.5 0.0 2.0 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_30 PF13556.1 CCF44944.1 - 0.0026 17.2 0.0 0.0059 16.1 0.0 1.6 2 0 0 2 2 2 1 PucR C-terminal helix-turn-helix domain HTH_23 PF13384.1 CCF44944.1 - 0.003 17.1 0.1 0.0073 15.9 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_8 PF02954.14 CCF44944.1 - 0.028 13.9 0.0 0.091 12.3 0.0 1.9 1 1 0 1 1 1 0 Bacterial regulatory protein, Fis family Glycos_transf_3 PF00591.16 CCF44945.1 - 0.033 13.5 0.0 0.035 13.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family, a/b domain Fungal_trans PF04082.13 CCF44946.1 - 4.1e-09 35.7 0.0 6e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DDE_1 PF03184.14 CCF44947.1 - 2.3e-25 89.0 0.0 2.7e-25 88.8 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease YL1_C PF08265.6 CCF44948.1 - 2.1e-12 46.3 0.4 3.4e-12 45.6 0.3 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain zf-HIT PF04438.11 CCF44948.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 HIT zinc finger FAM75 PF14650.1 CCF44948.1 - 0.13 11.5 13.7 0.17 11.2 9.5 1.2 1 0 0 1 1 1 0 FAM75 family PMI_typeI PF01238.16 CCF44950.1 - 4.3e-41 141.1 0.0 4.6e-41 141.0 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Adaptin_N PF01602.15 CCF44953.1 - 6.5e-123 410.8 9.9 7.8e-123 410.5 6.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.11 CCF44953.1 - 1.8e-47 159.9 0.0 6.2e-47 158.2 0.0 2.0 2 0 0 2 2 2 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.15 CCF44953.1 - 2e-19 70.0 0.0 3.7e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain FAD_binding_4 PF01565.18 CCF44955.1 - 4.1e-11 42.5 0.0 5.8e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain LCM PF04072.9 CCF44958.1 - 1.6e-23 83.2 0.0 2.2e-23 82.7 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_4 PF13418.1 CCF44958.1 - 0.005 16.5 0.1 0.017 14.8 0.1 2.0 1 0 0 1 1 1 1 Galactose oxidase, central domain DUF4551 PF15087.1 CCF44959.1 - 1.7 6.8 4.8 1.8 6.8 3.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) zf-B_box PF00643.19 CCF44960.1 - 0.6 10.0 8.4 1.5 8.7 5.9 1.7 1 1 0 1 1 1 0 B-box zinc finger zf-HIT PF04438.11 CCF44960.1 - 0.82 9.3 6.1 1.2 8.7 4.2 1.3 1 0 0 1 1 1 0 HIT zinc finger zf-ribbon_3 PF13248.1 CCF44960.1 - 2 7.7 5.4 0.39 9.9 1.1 1.8 2 0 0 2 2 2 0 zinc-ribbon domain NOB1_Zn_bind PF08772.6 CCF44960.1 - 9.4 6.1 8.5 27 4.6 0.8 2.2 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like p450 PF00067.17 CCF44961.1 - 9.1e-47 159.6 0.0 1.4e-46 159.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 DUF3920 PF13058.1 CCF44961.1 - 0.011 15.5 0.0 0.019 14.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3920) CUE PF02845.11 CCF44964.1 - 1.7e-11 43.3 0.0 2.5e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 CUE domain NOT2_3_5 PF04153.13 CCF44965.1 - 7.3e-28 97.1 0.4 1e-27 96.6 0.3 1.2 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family cobW PF02492.14 CCF44966.1 - 3.8e-25 88.3 0.1 5e-25 87.9 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 CCF44966.1 - 5.8e-05 22.7 0.1 0.00011 21.8 0.1 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain Rxt3 PF08642.5 CCF44967.1 - 1.2e-28 99.7 0.0 2.3e-28 98.7 0.0 1.5 1 0 0 1 1 1 1 Histone deacetylation protein Rxt3 LCCL PF03815.14 CCF44967.1 - 2.6e-06 27.3 0.0 0.0017 18.3 0.0 2.4 2 0 0 2 2 2 2 LCCL domain PBP PF01161.15 CCF44969.1 - 5.3e-10 39.3 0.0 9.5e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Tmemb_cc2 PF10267.4 CCF44970.1 - 0.058 11.9 11.4 0.07 11.7 7.9 1.0 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein TMPIT PF07851.8 CCF44970.1 - 3.5 6.6 5.4 4.3 6.3 3.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein RRN9 PF10680.4 CCF44971.1 - 2.3e-16 59.2 0.4 9.2e-16 57.3 0.3 2.1 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor HeLo PF14479.1 CCF44975.1 - 5.4e-35 121.0 0.1 6e-35 120.9 0.1 1.0 1 0 0 1 1 1 1 Prion-inhibition and propagation LamB_YcsF PF03746.11 CCF44976.1 - 4.8e-70 235.3 0.0 5.6e-70 235.1 0.0 1.0 1 0 0 1 1 1 1 LamB/YcsF family EHN PF06441.7 CCF44977.1 - 1.3e-38 131.3 1.5 6.6e-38 129.0 0.0 2.2 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_6 PF12697.2 CCF44977.1 - 2.1e-13 50.7 0.7 5.4e-13 49.3 0.2 1.9 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF44977.1 - 6.2e-09 35.7 0.0 8.5e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Calponin PF00402.13 CCF44977.1 - 0.15 11.4 0.2 0.25 10.7 0.2 1.4 1 0 0 1 1 1 0 Calponin family repeat Dodecin PF07311.7 CCF44980.1 - 0.18 11.8 1.8 2.3 8.3 0.1 2.9 2 1 1 3 3 3 0 Dodecin Peptidase_S10 PF00450.17 CCF44981.1 - 2e-73 247.9 0.0 3e-73 247.3 0.0 1.2 1 1 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 CCF44981.1 - 0.013 15.3 0.0 0.13 12.1 0.0 2.2 2 1 0 2 2 2 0 Alpha/beta hydrolase family MFS_1 PF07690.11 CCF44982.1 - 4e-06 25.7 21.8 4e-06 25.7 15.1 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Abhydrolase_6 PF12697.2 CCF44983.1 - 0.0043 16.9 0.4 0.0044 16.9 0.3 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF44983.1 - 0.13 12.0 0.0 0.14 11.9 0.0 1.0 1 0 0 1 1 1 0 Alpha/beta hydrolase family Microtub_assoc PF07989.6 CCF44987.1 - 5.2e-19 67.8 8.9 5.2e-19 67.8 6.2 8.2 8 1 1 9 9 9 1 Microtubule associated Mto2_bdg PF12808.2 CCF44987.1 - 3.3e-12 46.2 8.7 3.3e-12 46.2 6.0 13.7 14 2 1 16 16 16 2 Micro-tubular organiser Mto1 C-term Mto2-binding region Reo_sigmaC PF04582.7 CCF44987.1 - 0.0006 19.0 35.9 0.035 13.3 1.4 6.0 5 1 1 6 6 6 3 Reovirus sigma C capsid protein Fib_alpha PF08702.5 CCF44987.1 - 0.049 13.7 63.8 0.37 10.9 2.4 8.2 5 2 2 8 8 8 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.7 CCF44987.1 - 1.5 9.1 0.0 1.5 9.1 0.0 7.2 7 1 0 7 7 7 0 Nucleopolyhedrovirus P10 protein DUF1479 PF07350.7 CCF44988.1 - 2e-159 530.5 0.0 2.3e-159 530.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) PhyH PF05721.8 CCF44988.1 - 0.017 15.1 0.1 1.7 8.5 0.0 2.3 2 0 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) TauD PF02668.11 CCF44988.1 - 0.044 13.4 0.0 3.7 7.1 0.0 2.2 2 0 0 2 2 2 0 Taurine catabolism dioxygenase TauD, TfdA family Methyltransf_18 PF12847.2 CCF44989.1 - 1.6e-06 28.6 0.0 2.3e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF44989.1 - 3.3e-06 27.5 0.0 5.2e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF44989.1 - 6.7e-06 26.1 0.2 1.4e-05 25.0 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF44989.1 - 0.0069 16.8 0.0 0.01 16.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF44989.1 - 0.048 14.0 0.0 0.084 13.2 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain DUF1993 PF09351.5 CCF44990.1 - 1.4e-48 164.8 0.0 1.6e-48 164.6 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) DUF4252 PF14060.1 CCF44991.1 - 0.033 13.7 0.0 0.051 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) adh_short PF00106.20 CCF44992.1 - 9.8e-17 61.3 2.8 1.5e-16 60.7 1.9 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF44992.1 - 3.7e-12 46.2 2.1 5.6e-12 45.6 1.5 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF44992.1 - 0.0058 16.0 0.0 0.0071 15.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.15 CCF44992.1 - 0.0082 16.2 1.0 0.019 15.0 0.3 1.7 1 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.10 CCF44992.1 - 0.013 14.4 0.3 0.017 14.0 0.2 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 CCF44992.1 - 0.13 12.2 4.5 1.8 8.5 3.1 2.2 1 1 0 1 1 1 0 NADH(P)-binding Sugar_tr PF00083.19 CCF44994.1 - 5.9e-71 239.3 11.2 7.3e-71 239.0 7.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF44994.1 - 9.5e-11 40.9 18.5 9.5e-11 40.9 12.8 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF3149 PF11346.3 CCF44994.1 - 0.6 9.7 4.0 0.56 9.8 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3149) NAD_binding_10 PF13460.1 CCF44995.1 - 9e-15 55.1 0.2 3.1e-14 53.4 0.0 1.8 2 0 0 2 2 2 1 NADH(P)-binding NmrA PF05368.8 CCF44995.1 - 1e-13 51.1 0.0 1.4e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.16 CCF44995.1 - 1.4e-05 24.6 0.0 2.2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.19 CCF44995.1 - 0.0065 16.7 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain CPSase_L_chain PF00289.17 CCF44995.1 - 0.03 14.4 0.0 0.083 12.9 0.0 1.7 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, N-terminal domain 3Beta_HSD PF01073.14 CCF44995.1 - 0.12 11.1 0.0 0.21 10.2 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family PhoD PF09423.5 CCF44996.1 - 4.9e-158 526.4 5.2 5.7e-158 526.1 3.6 1.0 1 0 0 1 1 1 1 PhoD-like phosphatase Glyco_hydro_3 PF00933.16 CCF44999.1 - 1.1e-78 264.2 0.0 1.5e-78 263.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain NAD_binding_8 PF13450.1 CCF45000.1 - 0.0011 18.9 0.0 0.0019 18.1 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF45000.1 - 0.0016 18.5 1.5 0.012 15.7 1.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF45000.1 - 0.0019 18.0 0.2 0.0019 18.0 0.2 2.0 2 1 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.12 CCF45000.1 - 0.037 13.1 0.0 0.056 12.5 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.9 CCF45000.1 - 0.12 12.2 0.0 0.7 9.7 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Ribosomal_60s PF00428.14 CCF45000.1 - 0.35 11.2 5.1 0.71 10.3 3.5 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Epimerase PF01370.16 CCF45001.1 - 3.9e-05 23.2 0.0 4.1e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF45001.1 - 4.5e-05 23.5 0.0 5e-05 23.3 0.0 1.0 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF45001.1 - 0.00076 18.8 0.0 0.00085 18.6 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.20 CCF45001.1 - 0.024 14.5 0.0 0.026 14.4 0.0 1.1 1 0 0 1 1 1 0 short chain dehydrogenase F420_oxidored PF03807.12 CCF45001.1 - 0.058 13.8 0.0 0.064 13.6 0.0 1.1 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent MFS_1 PF07690.11 CCF45002.1 - 1.2e-09 37.3 23.0 2.2e-09 36.5 15.4 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily PUCC PF03209.10 CCF45002.1 - 0.0092 14.7 9.5 0.043 12.5 4.8 2.1 1 1 0 2 2 2 2 PUCC protein Sugar_tr PF00083.19 CCF45003.1 - 2.3e-53 181.3 3.0 2.8e-53 181.1 2.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF45003.1 - 4.9e-17 61.6 6.4 6.4e-17 61.2 4.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF45003.1 - 0.00027 19.4 0.1 0.00027 19.4 0.1 1.5 2 0 0 2 2 2 1 MFS/sugar transport protein DUF1547 PF07577.6 CCF45005.1 - 0.42 10.3 1.8 0.77 9.4 1.2 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1547) DUF1479 PF07350.7 CCF45006.1 - 5.4e-160 532.4 0.0 6.2e-160 532.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) HHH PF00633.18 CCF45007.1 - 0.0052 16.4 0.1 0.011 15.3 0.1 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif Cep57_MT_bd PF06657.8 CCF45007.1 - 0.019 14.8 0.8 1.8 8.5 0.2 2.3 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 RE_BstXI PF09552.5 CCF45007.1 - 0.074 12.0 0.1 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 BstXI restriction endonuclease HHH_5 PF14520.1 CCF45007.1 - 0.15 12.2 0.3 0.42 10.8 0.1 1.8 2 0 0 2 2 2 0 Helix-hairpin-helix domain zf-met2 PF12907.2 CCF45008.1 - 1.5e-17 63.2 2.3 2.4e-17 62.6 1.6 1.3 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.9 CCF45008.1 - 7.1e-06 26.6 9.9 7.1e-06 26.6 6.8 1.5 2 0 0 2 2 2 1 4F5 protein family HypA PF01155.14 CCF45008.1 - 0.059 13.0 0.3 0.064 12.9 0.2 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family DIOX_N PF14226.1 CCF45009.1 - 6.3e-31 107.3 0.0 4.8e-30 104.4 0.0 2.1 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 CCF45009.1 - 1.3e-13 51.0 0.0 2.3e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily WD40 PF00400.27 CCF45010.1 - 2.7e-05 23.8 0.2 1.9 8.5 0.0 4.3 5 0 0 5 5 5 2 WD domain, G-beta repeat Harakiri PF15196.1 CCF45010.1 - 0.0035 17.5 0.3 0.46 10.7 0.1 2.4 2 0 0 2 2 2 1 Activator of apoptosis harakiri Peptidase_S9_N PF02897.10 CCF45010.1 - 0.01 14.4 0.0 0.019 13.5 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase, N-terminal beta-propeller domain PQQ PF01011.16 CCF45010.1 - 0.051 13.1 0.4 0.25 10.9 0.1 2.4 2 0 0 2 2 2 0 PQQ enzyme repeat PQQ_3 PF13570.1 CCF45010.1 - 0.079 13.2 0.4 0.5 10.7 0.1 2.7 2 0 0 2 2 2 0 PQQ-like domain Lactonase PF10282.4 CCF45010.1 - 0.12 11.4 0.0 0.37 9.8 0.0 1.8 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller AA_permease PF00324.16 CCF45011.1 - 5.3e-33 114.0 21.9 6.5e-33 113.7 15.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF45011.1 - 4e-10 38.8 17.3 4.8e-10 38.5 12.0 1.0 1 0 0 1 1 1 1 Amino acid permease Bacteriocin_IIc PF10439.4 CCF45011.1 - 7.2 6.8 10.0 17 5.6 7.0 1.6 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Peptidase_A22B PF04258.8 CCF45012.1 - 5.9e-13 48.9 5.5 4.9e-12 45.9 3.8 1.9 1 1 0 1 1 1 1 Signal peptide peptidase DUF457 PF04307.9 CCF45012.1 - 0.24 10.7 4.0 0.12 11.7 0.4 2.0 2 0 0 2 2 2 0 Predicted membrane-bound metal-dependent hydrolase (DUF457) FA_hydroxylase PF04116.8 CCF45012.1 - 4.8 7.6 10.0 1.3 9.3 3.0 2.2 2 0 0 2 2 2 0 Fatty acid hydroxylase superfamily CHZ PF09649.5 CCF45014.1 - 8.3e-16 56.9 0.3 8.3e-16 56.9 0.2 2.4 3 0 0 3 3 3 1 Histone chaperone domain CHZ ADH_N PF08240.7 CCF45016.1 - 5.5e-08 32.5 0.5 4.3e-06 26.4 0.1 2.2 1 1 1 2 2 2 2 Alcohol dehydrogenase GroES-like domain ketoacyl-synt PF00109.21 CCF45017.1 - 2.8e-71 239.9 0.0 3.1e-71 239.8 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.18 CCF45017.1 - 0.00021 20.3 0.0 0.00028 19.9 0.0 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Enolase_N PF03952.11 CCF45017.1 - 0.029 14.3 0.0 0.041 13.8 0.0 1.2 1 0 0 1 1 1 0 Enolase, N-terminal domain ACP_syn_III PF08545.5 CCF45017.1 - 0.033 13.8 0.5 0.075 12.6 0.3 1.6 1 1 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III MDMPI_C PF07398.6 CCF45018.1 - 0.032 14.8 2.5 0.068 13.7 1.8 1.7 1 1 0 1 1 1 0 MDMPI C-terminal domain NCD2 PF04905.8 CCF45019.1 - 0.013 15.2 0.3 0.015 15.0 0.2 1.0 1 0 0 1 1 1 0 NAB conserved region 2 (NCD2) zf-C2H2_4 PF13894.1 CCF45020.1 - 2.9e-06 27.2 12.7 0.00054 20.1 1.3 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CCF45020.1 - 5.9e-06 26.3 4.0 5.9e-06 26.3 2.8 3.1 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2 PF00096.21 CCF45020.1 - 1.3e-05 25.2 11.4 0.006 16.8 0.9 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type DUF3821 PF12863.2 CCF45020.1 - 0.051 13.2 0.0 0.089 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3821) Nucleo_P87 PF07267.6 CCF45020.1 - 0.13 10.9 4.7 0.24 10.0 3.3 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 PBP1_TM PF14812.1 CCF45020.1 - 0.44 10.8 7.9 0.96 9.7 5.4 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-C2H2_6 PF13912.1 CCF45020.1 - 2.5 8.1 5.8 0.33 10.9 0.6 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger CobT PF06213.7 CCF45020.1 - 3.4 6.7 7.4 5.2 6.1 5.2 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT MCM PF00493.18 CCF45021.1 - 2.1e-139 463.9 0.0 2.1e-139 463.9 0.0 1.7 2 0 0 2 2 2 1 MCM2/3/5 family MCM2_N PF12619.3 CCF45021.1 - 2e-31 109.1 37.0 2e-31 109.1 25.6 2.7 3 0 0 3 3 3 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.1 CCF45021.1 - 5.1e-21 75.3 0.1 1.2e-20 74.1 0.1 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 CCF45021.1 - 1e-07 31.3 0.8 5.3e-06 25.7 0.0 2.9 2 1 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 CCF45021.1 - 1.9e-06 27.6 0.0 4.5e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.21 CCF45021.1 - 0.002 17.6 0.2 0.014 14.8 0.1 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.6 CCF45021.1 - 0.0035 16.9 0.1 0.017 14.7 0.0 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) zf-TFIIB PF13453.1 CCF45021.1 - 0.25 10.5 1.2 0.56 9.4 0.8 1.6 1 0 0 1 1 1 0 Transcription factor zinc-finger zf-rbx1 PF12678.2 CCF45023.1 - 7.9e-11 41.9 13.7 1.7e-09 37.6 1.5 3.0 2 2 0 2 2 2 2 RING-H2 zinc finger zf-RING_2 PF13639.1 CCF45023.1 - 1.2e-09 37.8 0.9 1.2e-09 37.8 0.6 4.3 4 1 1 5 5 5 1 Ring finger domain PHD PF00628.24 CCF45023.1 - 1.4e-09 37.4 15.4 2.3e-09 36.7 5.3 2.7 2 0 0 2 2 2 1 PHD-finger zf-C3HC4_3 PF13920.1 CCF45023.1 - 7.3e-07 28.7 0.5 7.3e-07 28.7 0.3 4.8 5 1 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) PHD_2 PF13831.1 CCF45023.1 - 2.2e-06 26.8 3.5 2.2e-06 26.8 2.4 2.5 2 0 0 2 2 2 1 PHD-finger zf-C3HC4 PF00097.20 CCF45023.1 - 3.5e-06 26.5 2.3 3.5e-06 26.5 1.6 3.4 2 2 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.1 CCF45023.1 - 1.9e-05 24.1 4.0 0.00025 20.5 0.2 3.2 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.1 CCF45023.1 - 1.9e-05 24.2 0.6 1.9e-05 24.2 0.4 4.2 4 1 1 5 5 4 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CCF45023.1 - 3.4e-05 23.7 0.8 3.4e-05 23.7 0.6 5.0 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-PHD-like PF15446.1 CCF45023.1 - 0.00045 19.5 2.9 0.0012 18.1 0.8 2.4 2 0 0 2 2 2 1 PHD/FYVE-zinc-finger like domain zf-Apc11 PF12861.2 CCF45023.1 - 0.0016 18.2 11.7 0.016 15.0 0.8 2.8 1 1 0 2 2 2 2 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_1 PF14446.1 CCF45023.1 - 0.0017 18.0 3.9 0.0096 15.6 1.1 2.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 Rtf2 PF04641.7 CCF45023.1 - 0.015 14.5 0.6 0.037 13.2 0.4 1.8 1 1 0 1 1 1 0 Rtf2 RING-finger zf-P11 PF03854.9 CCF45023.1 - 0.022 14.2 0.4 0.022 14.2 0.3 2.7 4 0 0 4 4 3 0 P-11 zinc finger zf-RING_6 PF14835.1 CCF45023.1 - 0.1 12.3 0.3 0.1 12.3 0.2 2.9 3 0 0 3 3 3 0 zf-RING of BARD1-type protein DUF4463 PF14703.1 CCF45023.1 - 0.12 12.8 0.3 0.31 11.5 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4463) Rad50_zn_hook PF04423.9 CCF45023.1 - 0.12 11.8 2.1 0.7 9.4 0.1 2.3 2 0 0 2 2 2 0 Rad50 zinc hook motif DUF1644 PF07800.7 CCF45023.1 - 4.7 7.0 10.5 0.41 10.4 0.7 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1644) ATG_C PF09333.6 CCF45024.1 - 1.5e-07 31.4 0.0 1.2e-06 28.5 0.0 2.1 2 0 0 2 2 2 1 ATG C terminal domain 2OG-FeII_Oxy PF03171.15 CCF45025.1 - 0.12 12.6 0.1 0.32 11.3 0.1 1.9 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Prim_Zn_Ribbon PF08273.7 CCF45025.1 - 0.79 9.8 9.3 6.4 6.9 2.3 3.1 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase WD40 PF00400.27 CCF45027.1 - 2.1e-24 84.4 1.1 1e-11 44.2 0.1 2.0 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.3 CCF45027.1 - 0.0016 16.6 0.1 0.0016 16.6 0.0 1.0 1 0 0 1 1 1 1 Nucleoporin Nup120/160 PQQ_2 PF13360.1 CCF45027.1 - 0.0088 15.5 0.1 0.0088 15.5 0.1 1.1 1 0 0 1 1 1 1 PQQ-like domain SEF14_adhesin PF06443.6 CCF45027.1 - 0.034 13.8 0.3 0.039 13.5 0.2 1.0 1 0 0 1 1 1 0 SEF14-like adhesin DUF946 PF06101.6 CCF45029.1 - 1.4e-11 43.1 3.7 2.6e-11 42.2 0.1 2.2 3 0 0 3 3 3 2 Plant protein of unknown function (DUF946) Carb_anhydrase PF00194.16 CCF45030.1 - 7.1e-08 31.7 0.0 8.1e-08 31.5 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Glyco_hydro_28 PF00295.12 CCF45031.1 - 2.8e-32 111.9 1.5 3.2e-32 111.7 1.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase PF03211.8 CCF45035.1 - 2e-68 230.0 2.3 2.4e-68 229.7 1.6 1.0 1 0 0 1 1 1 1 Pectate lyase Tannase PF07519.6 CCF45036.1 - 4.3e-92 309.3 0.2 5e-92 309.0 0.1 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_6 PF12697.2 CCF45036.1 - 9.8e-05 22.3 0.0 0.00035 20.5 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF45036.1 - 0.00039 19.7 0.0 0.5 9.5 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 CCF45036.1 - 0.0006 19.4 0.0 0.0013 18.2 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF45036.1 - 0.0036 17.0 0.4 0.34 10.6 0.0 2.6 2 1 1 3 3 3 1 Alpha/beta hydrolase family Esterase PF00756.15 CCF45036.1 - 0.069 12.5 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Putative esterase Cu-oxidase PF00394.17 CCF45037.1 - 2.1e-28 99.2 0.0 3.1e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 CCF45037.1 - 9.9e-26 89.8 0.5 2e-25 88.9 0.4 1.5 1 0 0 1 1 1 1 Multicopper oxidase Sec34 PF04136.10 CCF45038.1 - 3.1e-31 108.1 1.2 9.2e-31 106.6 0.2 2.1 2 0 0 2 2 2 1 Sec34-like family NTP_transf_3 PF12804.2 CCF45039.1 - 0.049 13.7 0.0 0.053 13.5 0.0 1.1 1 0 0 1 1 1 0 MobA-like NTP transferase domain Hydrolase PF00702.21 CCF45040.1 - 8.9e-12 45.8 0.0 1.7e-11 44.9 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 CCF45040.1 - 1.5e-06 28.5 0.0 3.6e-06 27.2 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CCF45040.1 - 0.00031 20.3 0.1 0.00058 19.5 0.1 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase AA_permease_C PF13906.1 CCF45040.1 - 2 8.3 7.2 1.1 9.1 2.0 2.5 2 0 0 2 2 2 0 C-terminus of AA_permease UBA_4 PF14555.1 CCF45041.1 - 0.11 12.0 0.1 0.26 10.8 0.0 1.8 1 1 0 1 1 1 0 UBA-like domain Helicase_C PF00271.26 CCF45043.1 - 0.00075 19.3 0.0 0.002 17.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain adh_short PF00106.20 CCF45044.1 - 2.3e-10 40.6 0.0 3.5e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.7 CCF45044.1 - 0.00025 20.0 0.0 0.00033 19.6 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Shikimate_DH PF01488.15 CCF45044.1 - 0.00037 20.6 0.0 0.00058 19.9 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.16 CCF45044.1 - 0.00047 19.6 0.0 0.0016 17.8 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF45044.1 - 0.00087 19.3 0.0 0.0025 17.8 0.0 1.7 2 0 0 2 2 2 1 NADH(P)-binding KR PF08659.5 CCF45044.1 - 0.0016 18.1 0.0 0.0027 17.4 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 CCF45044.1 - 0.024 13.5 0.0 0.031 13.1 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Semialdhyde_dh PF01118.19 CCF45044.1 - 0.083 13.1 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.8 CCF45044.1 - 0.12 11.6 0.0 0.21 10.7 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family Ank PF00023.25 CCF45045.1 - 1.2e-14 53.2 0.0 3.3e-07 29.7 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 CCF45045.1 - 1.8e-12 47.4 0.0 8.7e-09 35.6 0.0 4.1 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.2 CCF45045.1 - 9.4e-12 45.1 0.0 2.4e-11 43.8 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 CCF45045.1 - 5.2e-10 38.5 0.0 7.5e-06 25.7 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 CCF45045.1 - 8.3e-08 32.2 0.0 2e-06 27.8 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) NMD3 PF04981.8 CCF45046.1 - 2.6e-70 236.2 3.0 4e-70 235.5 2.1 1.3 1 0 0 1 1 1 1 NMD3 family DUF35_N PF12172.3 CCF45046.1 - 0.0016 18.2 0.5 0.41 10.6 0.2 2.7 2 0 0 2 2 2 2 Rubredoxin-like zinc ribbon domain (DUF35_N) HABP4_PAI-RBP1 PF04774.10 CCF45049.1 - 0.0035 17.8 3.0 0.0061 17.0 2.1 1.5 1 1 0 1 1 1 1 Hyaluronan / mRNA binding family Fis1_TPR_C PF14853.1 CCF45050.1 - 0.025 14.4 0.0 0.052 13.4 0.0 1.5 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat PMP1_2 PF08114.6 CCF45051.1 - 0.047 13.1 0.8 2.9 7.4 0.0 3.2 3 0 0 3 3 3 0 ATPase proteolipid family Neurochondrin PF05536.6 CCF45052.1 - 1e-45 156.1 0.2 1.2e-45 155.8 0.1 1.0 1 0 0 1 1 1 1 Neurochondrin adh_short PF00106.20 CCF45056.1 - 6.8e-14 52.1 0.5 8.7e-14 51.7 0.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF45056.1 - 1.3e-07 31.4 0.1 1.5e-07 31.2 0.1 1.1 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF45056.1 - 5.5e-07 29.5 0.1 6.8e-07 29.2 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 CCF45056.1 - 0.003 17.0 0.1 0.0034 16.8 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family CHB_HEX_C_1 PF13290.1 CCF45056.1 - 0.008 15.9 0.0 0.017 14.9 0.0 1.5 2 0 0 2 2 2 1 Chitobiase/beta-hexosaminidase C-terminal domain CHB_HEX_C PF03174.8 CCF45056.1 - 0.042 13.6 0.1 0.095 12.5 0.0 1.7 2 0 0 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain Fibrillarin PF01269.12 CCF45056.1 - 0.044 12.6 0.0 0.05 12.5 0.0 1.1 1 0 0 1 1 1 0 Fibrillarin PBP_like_2 PF12849.2 CCF45056.1 - 0.082 12.3 0.2 0.088 12.2 0.2 1.0 1 0 0 1 1 1 0 PBP superfamily domain F-box PF00646.28 CCF45059.1 - 0.045 13.4 0.0 13 5.6 0.0 2.3 2 0 0 2 2 2 0 F-box domain Sigma70_r3 PF04539.11 CCF45059.1 - 0.062 13.1 0.1 0.17 11.7 0.0 1.7 2 0 0 2 2 2 0 Sigma-70 region 3 Mito_carr PF00153.22 CCF45060.1 - 7.5e-11 41.5 0.0 8.4e-11 41.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein GTP_EFTU PF00009.22 CCF45061.1 - 1.6e-39 135.3 0.2 1.9e-39 135.0 0.1 1.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CCF45061.1 - 0.00012 21.9 0.1 0.00034 20.5 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CCF45061.1 - 0.016 15.7 0.1 0.14 12.6 0.1 2.0 1 1 0 1 1 1 0 Miro-like protein Dynamin_N PF00350.18 CCF45061.1 - 0.039 13.7 0.3 2.6 7.8 0.1 2.1 1 1 1 2 2 2 0 Dynamin family MobB PF03205.9 CCF45061.1 - 0.041 13.5 0.1 0.062 12.9 0.1 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Fibrinogen_aC PF12160.3 CCF45061.1 - 0.092 12.2 0.1 0.63 9.5 0.0 2.0 2 0 0 2 2 2 0 Fibrinogen alpha C domain Septin PF00735.13 CCF45061.1 - 0.12 11.4 0.0 0.34 9.8 0.0 1.6 1 1 0 1 1 1 0 Septin Polyoma_lg_T_C PF06431.6 CCF45061.1 - 0.12 10.9 0.0 0.15 10.6 0.0 1.1 1 0 0 1 1 1 0 Polyomavirus large T antigen C-terminus G-alpha PF00503.15 CCF45061.1 - 0.13 10.9 0.0 0.17 10.5 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Phosphodiest PF01663.17 CCF45063.1 - 4.2e-85 286.2 0.3 5.5e-85 285.8 0.2 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 CCF45063.1 - 0.03 13.5 0.2 0.9 8.6 0.1 2.3 2 1 0 2 2 2 0 Sulfatase ATG27 PF09451.5 CCF45063.1 - 0.051 12.8 0.0 0.11 11.6 0.0 1.5 1 0 0 1 1 1 0 Autophagy-related protein 27 Peptidase_S29 PF02907.10 CCF45066.1 - 0.14 11.6 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Ribosomal_S10 PF00338.17 CCF45068.1 - 3.8e-29 100.3 0.4 4.5e-29 100.1 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Fibrillarin_2 PF10113.4 CCF45068.1 - 0.033 12.5 0.0 0.033 12.5 0.0 1.1 1 0 0 1 1 1 0 Fibrillarin-like archaeal protein NACHT PF05729.7 CCF45070.1 - 1.2e-06 28.3 0.0 2.9e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 CCF45070.1 - 0.00033 20.6 0.0 0.001 19.0 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CCF45070.1 - 0.024 14.7 0.0 0.074 13.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain MFS_1 PF07690.11 CCF45072.1 - 6.3e-37 127.0 49.0 5.5e-36 124.0 33.4 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF45072.1 - 1.2e-14 53.5 20.3 1.5e-14 53.1 14.0 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 CCF45072.1 - 2.2e-10 39.7 7.6 2.2e-10 39.7 5.3 2.7 3 1 1 4 4 4 2 Sugar (and other) transporter OATP PF03137.15 CCF45072.1 - 0.36 8.8 5.0 0.55 8.2 0.4 2.4 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family HEV_ORF1 PF02444.11 CCF45074.1 - 0.049 13.8 2.3 0.049 13.8 1.6 2.6 1 1 2 3 3 3 0 Hepatitis E virus ORF-2 (Putative capsid protein) EphA2_TM PF14575.1 CCF45076.1 - 0.014 15.7 0.6 7.7 6.9 0.2 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain HATPase_c_3 PF13589.1 CCF45076.1 - 0.02 14.5 0.1 0.053 13.1 0.1 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IncA PF04156.9 CCF45076.1 - 0.036 13.6 1.8 0.081 12.5 1.3 1.5 1 1 0 1 1 1 0 IncA protein Suf PF05843.9 CCF45076.1 - 6.2 6.4 5.8 13 5.3 4.0 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Pro_CA PF00484.14 CCF45077.1 - 3e-49 166.9 0.0 3.9e-49 166.5 0.0 1.1 1 0 0 1 1 1 1 Carbonic anhydrase SopA PF13981.1 CCF45077.1 - 0.034 14.1 0.1 0.084 12.9 0.1 1.6 1 0 0 1 1 1 0 SopA-like central domain DUF912 PF06024.7 CCF45081.1 - 2.2 8.3 3.7 3.9 7.5 2.5 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Fungal_trans_2 PF11951.3 CCF45082.1 - 4.4e-78 262.5 0.0 5.4e-78 262.2 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain DASH_Spc19 PF08287.6 CCF45083.1 - 1.3e-23 83.3 0.0 1.4e-23 83.2 0.0 1.0 1 0 0 1 1 1 1 Spc19 PMEI PF04043.10 CCF45083.1 - 0.05 13.5 0.1 0.059 13.2 0.0 1.2 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor Fungal_trans_2 PF11951.3 CCF45086.1 - 0.00063 18.4 0.2 0.00089 17.9 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Thi4 PF01946.12 CCF45087.1 - 7.8e-108 358.8 0.2 9.3e-108 358.6 0.2 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.19 CCF45087.1 - 1.7e-09 37.0 0.8 3.1e-08 32.9 0.7 2.0 1 1 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 CCF45087.1 - 1.2e-05 24.3 0.6 9.1e-05 21.5 0.3 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 CCF45087.1 - 6.8e-05 22.8 0.3 0.00016 21.6 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 CCF45087.1 - 0.00032 20.5 1.1 0.00062 19.5 0.0 2.0 3 0 0 3 3 3 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.19 CCF45087.1 - 0.00057 18.8 5.6 0.0053 15.6 0.9 2.6 2 1 1 3 3 3 1 FAD binding domain Pyr_redox_3 PF13738.1 CCF45087.1 - 0.0013 18.8 0.4 0.002 18.1 0.3 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CCF45087.1 - 0.0017 18.2 0.7 0.0028 17.5 0.5 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 CCF45087.1 - 0.0074 15.3 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 CCF45087.1 - 0.027 13.5 0.4 0.051 12.6 0.3 1.4 1 1 0 1 1 1 0 FAD dependent oxidoreductase Macoilin PF09726.4 CCF45089.1 - 0.013 13.7 1.1 0.017 13.4 0.8 1.0 1 0 0 1 1 1 0 Transmembrane protein FlxA PF14282.1 CCF45089.1 - 0.027 14.3 1.2 0.046 13.6 0.0 2.1 2 0 0 2 2 2 0 FlxA-like protein LPP PF04728.8 CCF45089.1 - 0.045 13.5 0.2 0.15 11.8 0.1 1.8 1 1 1 2 2 2 0 Lipoprotein leucine-zipper Zip PF02535.17 CCF45091.1 - 0.33 9.9 4.9 0.29 10.1 3.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter KASH PF10541.4 CCF45092.1 - 0.29 11.0 4.2 0.42 10.4 2.9 1.3 1 0 0 1 1 1 0 Nuclear envelope localisation domain DDE_1 PF03184.14 CCF45093.1 - 3.8e-57 192.9 0.0 6.3e-57 192.1 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.11 CCF45093.1 - 6.8e-14 51.1 0.2 1.3e-13 50.2 0.2 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF45093.1 - 1.2e-11 44.2 0.0 3.8e-11 42.6 0.0 1.9 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.1 CCF45093.1 - 2.7e-08 33.6 0.0 6.2e-08 32.5 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.1 CCF45093.1 - 0.00038 19.9 0.0 0.0011 18.4 0.0 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 CCF45093.1 - 0.0016 18.3 0.1 0.0042 17.0 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_7 PF02796.10 CCF45093.1 - 0.0029 17.4 0.1 0.0065 16.3 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.1 CCF45093.1 - 0.012 15.1 0.0 0.026 14.1 0.0 1.5 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Complex1_LYR PF05347.10 CCF45094.1 - 3.2e-09 36.4 0.1 6.1e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 CCF45094.1 - 2.2e-08 34.1 0.0 4.6e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Complex1_LYR-like DUF4018 PF13210.1 CCF45094.1 - 0.025 13.9 0.0 0.032 13.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4018) Spt5_N PF11942.3 CCF45095.1 - 1.1 9.9 7.6 0.23 12.0 0.3 2.5 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal RNase_H PF00075.19 CCF45096.1 - 5.4e-29 101.1 0.1 1e-28 100.2 0.1 1.4 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.11 CCF45096.1 - 2.9e-26 91.1 3.8 4.2e-16 58.6 0.4 2.7 2 0 0 2 2 2 2 Caulimovirus viroplasmin GARS_A PF01071.14 CCF45096.1 - 0.07 12.6 0.1 0.71 9.4 0.0 2.1 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Telomerase_RBD PF12009.3 CCF45097.1 - 8e-41 139.1 0.2 1.7e-40 138.1 0.1 1.6 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.22 CCF45097.1 - 3.2e-17 62.6 0.0 2.2e-16 59.8 0.0 2.2 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2171 PF09939.4 CCF45098.1 - 0.23 11.4 0.2 0.23 11.4 0.1 2.3 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2171) DEAD PF00270.24 CCF45100.1 - 2.5e-30 105.1 0.0 4.7e-30 104.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF45100.1 - 6.1e-18 64.4 0.0 1.2e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF45100.1 - 1e-05 25.4 0.0 1.8e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 CCF45100.1 - 0.039 12.7 0.0 0.061 12.1 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain ketoacyl-synt PF00109.21 CCF45102.1 - 1.6e-40 139.2 0.5 9.2e-39 133.4 0.3 2.4 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain DUF2280 PF10045.4 CCF45102.1 - 0.17 11.8 0.0 0.42 10.5 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2280) CD20 PF04103.10 CCF45103.1 - 0.12 12.3 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 CD20-like family DUF4051 PF13260.1 CCF45104.1 - 0.093 12.0 0.8 0.093 12.0 0.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4051) DUF3382 PF11862.3 CCF45104.1 - 0.57 10.1 4.3 0.82 9.6 3.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3382) STb_secrete PF09075.5 CCF45104.1 - 0.71 9.7 4.5 10 6.0 0.2 2.3 1 1 1 2 2 2 0 Heat-stable enterotoxin B, secretory Ribosomal_S5_C PF03719.10 CCF45105.1 - 2.7e-16 58.5 0.0 2.3e-15 55.6 0.0 2.4 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.15 CCF45105.1 - 4.3e-10 39.1 0.7 9.8e-10 38.0 0.5 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain RWD PF05773.17 CCF45106.1 - 3.8e-24 84.7 0.0 5.4e-24 84.2 0.0 1.2 1 0 0 1 1 1 1 RWD domain zf-RING_2 PF13639.1 CCF45106.1 - 5.7e-05 22.8 7.5 9.2e-05 22.1 5.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 CCF45106.1 - 0.00059 19.8 8.6 0.001 19.0 6.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF45106.1 - 0.00087 18.8 8.2 0.0015 18.1 5.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF45106.1 - 0.00091 18.9 7.4 0.0017 18.0 5.1 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 CCF45106.1 - 0.0056 16.3 3.8 0.011 15.4 2.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 CCF45106.1 - 0.019 14.8 7.7 0.068 13.0 5.4 2.0 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Baculo_RING PF05883.6 CCF45106.1 - 0.03 14.1 1.7 0.048 13.4 1.2 1.3 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain IBR PF01485.16 CCF45106.1 - 6.3 6.7 8.4 3.4 7.6 2.7 2.3 1 1 1 2 2 2 0 IBR domain PRP1_N PF06424.7 CCF45109.1 - 6.1e-53 178.7 8.2 1.6e-52 177.3 5.7 1.8 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.1 CCF45109.1 - 8.8e-34 112.9 29.5 0.0035 17.8 0.0 14.4 4 3 10 14 14 14 11 Tetratricopeptide repeat TPR_16 PF13432.1 CCF45109.1 - 7.2e-28 96.6 18.3 7e-08 32.9 0.8 9.6 6 2 1 9 9 9 6 Tetratricopeptide repeat TPR_19 PF14559.1 CCF45109.1 - 2.5e-25 88.6 18.0 7.7e-07 29.3 0.3 9.4 5 3 5 10 10 10 7 Tetratricopeptide repeat TPR_2 PF07719.12 CCF45109.1 - 7.8e-16 56.6 7.8 0.2 11.6 0.0 10.6 11 1 1 12 12 10 2 Tetratricopeptide repeat TPR_11 PF13414.1 CCF45109.1 - 9.3e-16 57.2 13.5 0.0023 17.5 0.0 8.5 5 3 1 8 8 8 3 TPR repeat TPR_15 PF13429.1 CCF45109.1 - 7.5e-10 38.3 18.7 8.5e-05 21.7 3.8 6.6 2 2 3 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.1 CCF45109.1 - 2e-09 36.9 5.6 4.9 7.5 0.0 8.6 7 2 1 8 8 7 1 Tetratricopeptide repeat TPR_8 PF13181.1 CCF45109.1 - 5.4e-09 35.1 0.2 0.6 10.0 0.0 7.7 9 0 0 9 9 8 1 Tetratricopeptide repeat NARP1 PF12569.3 CCF45109.1 - 1.7e-07 30.4 9.9 0.08 11.6 0.0 6.1 4 1 2 6 6 6 2 NMDA receptor-regulated protein 1 TPR_6 PF13174.1 CCF45109.1 - 2.4e-07 30.7 3.1 9.3 6.9 0.0 8.8 9 0 0 9 9 8 0 Tetratricopeptide repeat TPR_1 PF00515.23 CCF45109.1 - 1.2e-06 27.8 0.2 0.76 9.4 0.0 5.6 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_9 PF13371.1 CCF45109.1 - 5.9e-06 26.0 6.4 0.032 14.0 0.0 6.0 5 1 0 6 6 6 1 Tetratricopeptide repeat Suf PF05843.9 CCF45109.1 - 7.8e-06 25.8 0.5 0.45 10.1 0.0 5.1 4 1 1 5 5 5 1 Suppressor of forked protein (Suf) TPR_12 PF13424.1 CCF45109.1 - 5.8e-05 22.9 9.2 0.41 10.6 0.0 6.2 7 1 0 7 7 7 2 Tetratricopeptide repeat Apc3 PF12895.2 CCF45109.1 - 0.0006 19.9 0.2 6.5 6.9 0.0 4.8 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 NRDE-2 PF08424.5 CCF45109.1 - 0.001 18.0 0.1 0.001 18.0 0.1 5.7 4 2 2 6 6 6 3 NRDE-2, necessary for RNA interference FAT PF02259.18 CCF45109.1 - 0.0012 17.9 6.6 3.8 6.4 0.0 4.6 4 1 1 5 5 5 2 FAT domain DUF3808 PF10300.4 CCF45109.1 - 0.12 10.9 1.5 7.5 4.9 0.0 3.7 3 1 2 5 5 5 0 Protein of unknown function (DUF3808) TPR_7 PF13176.1 CCF45109.1 - 0.46 10.4 10.4 6.5 6.8 0.0 6.2 9 0 0 9 9 5 0 Tetratricopeptide repeat ChAPs PF09295.5 CCF45109.1 - 0.81 8.3 5.5 4.7 5.8 0.2 3.2 2 1 1 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_10 PF13374.1 CCF45109.1 - 1.3 9.0 6.7 96 3.1 0.0 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.4 CCF45109.1 - 2.4 8.0 25.4 0.13 12.2 1.8 5.2 4 1 1 5 5 5 0 Tetratricopeptide repeat Apolipoprotein PF01442.13 CCF45110.1 - 0.006 16.1 0.4 0.0099 15.4 0.3 1.4 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain V-ATPase_G PF03179.10 CCF45110.1 - 0.4 11.0 7.4 0.2 11.9 3.6 1.6 2 0 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit MRFAP1 PF15155.1 CCF45110.1 - 3.1 8.1 5.3 3.4 8.0 2.3 1.8 1 1 1 2 2 2 0 MORF4 family-associated protein1 PPR_2 PF13041.1 CCF45112.1 - 0.0031 17.4 0.1 0.21 11.6 0.0 2.8 2 2 1 3 3 3 1 PPR repeat family MARVEL PF01284.18 CCF45116.1 - 0.26 11.0 16.8 0.54 10.0 11.6 1.5 1 1 0 1 1 1 0 Membrane-associating domain DUF3488 PF11992.3 CCF45116.1 - 5.1 5.6 7.8 0.77 8.3 1.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3488) Inositol_P PF00459.20 CCF45117.1 - 1.4e-39 136.0 0.0 1.6e-39 135.8 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family DUF331 PF03889.8 CCF45117.1 - 0.071 12.4 0.4 0.12 11.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function Methyltransf_16 PF10294.4 CCF45119.1 - 4.6e-10 39.2 0.0 0.0008 18.9 0.0 2.1 2 0 0 2 2 2 2 Putative methyltransferase Methyltransf_23 PF13489.1 CCF45119.1 - 0.014 15.1 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Aconitase_C PF00694.14 CCF45120.1 - 4e-36 124.0 0.0 6.1e-36 123.4 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain Aconitase_2_N PF06434.8 CCF45120.1 - 0.099 12.0 0.1 0.48 9.8 0.1 1.9 1 1 0 1 1 1 0 Aconitate hydratase 2 N-terminus DUF1977 PF09320.6 CCF45121.1 - 1.8e-20 73.1 0.0 2.2e-20 72.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) UPRTase PF14681.1 CCF45122.1 - 1.9e-32 112.1 0.0 3.7e-32 111.2 0.0 1.5 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 CCF45122.1 - 2.3e-05 24.1 1.3 0.0014 18.3 0.8 2.6 2 0 0 2 2 2 1 Phosphoribosyl transferase domain Hydrolase PF00702.21 CCF45122.1 - 5.5e-05 23.6 0.0 9.3e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 CCF45122.1 - 0.00064 19.9 0.0 0.0012 19.1 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PRTase_2 PF15609.1 CCF45122.1 - 0.033 13.4 0.0 0.097 11.9 0.0 1.8 1 0 0 1 1 1 0 Phosphoribosyl transferase DUF423 PF04241.10 CCF45124.1 - 0.0055 16.6 0.1 0.011 15.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF423) Ecm29 PF13001.2 CCF45125.1 - 1.1e-05 24.1 0.2 1.3e-05 23.9 0.1 1.0 1 0 0 1 1 1 1 Proteasome stabiliser Transglut_i_TM PF14400.1 CCF45126.1 - 0.11 11.9 0.2 0.15 11.5 0.1 1.1 1 0 0 1 1 1 0 Inactive transglutaminase fused to 7 transmembrane helices Fructosamin_kin PF03881.9 CCF45127.1 - 3.4e-75 252.6 0.0 4e-75 252.4 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.18 CCF45127.1 - 0.0013 18.5 0.0 0.002 17.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.6 CCF45127.1 - 0.0063 15.2 0.0 0.0094 14.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) RHD3 PF05879.7 CCF45128.1 - 0 1050.1 0.0 0 1049.8 0.0 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.14 CCF45128.1 - 1e-09 37.8 0.3 1.7e-09 37.1 0.2 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.18 CCF45128.1 - 2e-07 30.9 0.0 3.9e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Dynamin family AAA_28 PF13521.1 CCF45128.1 - 0.00013 22.0 0.0 0.00066 19.6 0.0 2.3 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 CCF45128.1 - 0.00017 21.5 0.0 0.0004 20.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CCF45128.1 - 0.00061 20.2 0.1 0.0012 19.2 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein Septin PF00735.13 CCF45128.1 - 0.027 13.4 0.1 0.045 12.7 0.1 1.3 1 0 0 1 1 1 0 Septin GTP_EFTU PF00009.22 CCF45128.1 - 0.14 11.5 0.1 0.61 9.5 0.0 2.0 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain DDE_1 PF03184.14 CCF45131.1 - 2.7e-50 170.5 0.0 5e-50 169.6 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.11 CCF45131.1 - 2.3e-12 46.2 0.1 5e-12 45.1 0.1 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF45131.1 - 8.9e-11 41.4 0.0 2e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain ABC_tran PF00005.22 CCF45132.1 - 3.5e-47 160.1 0.0 1.8e-25 89.8 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 CCF45132.1 - 2.5e-31 109.1 36.7 7.2e-28 97.7 9.9 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.1 CCF45132.1 - 4.2e-15 56.4 1.1 1.4e-06 28.5 0.2 4.5 3 1 0 3 3 3 2 AAA domain SMC_N PF02463.14 CCF45132.1 - 1.3e-11 44.1 1.4 0.0029 16.8 0.1 3.8 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 CCF45132.1 - 5.4e-08 33.4 0.0 0.00074 19.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 CCF45132.1 - 5.9e-08 32.1 0.2 0.0043 16.5 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 CCF45132.1 - 1.7e-06 27.3 0.3 0.032 13.4 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 T2SE PF00437.15 CCF45132.1 - 4.4e-06 25.7 0.0 0.013 14.4 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_25 PF13481.1 CCF45132.1 - 5.4e-06 25.9 0.0 0.043 13.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_10 PF12846.2 CCF45132.1 - 2.2e-05 24.0 0.5 0.2 11.0 0.0 3.2 3 0 0 3 3 3 2 AAA-like domain Miro PF08477.8 CCF45132.1 - 6.1e-05 23.4 0.2 0.038 14.4 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein MMR_HSR1 PF01926.18 CCF45132.1 - 0.00018 21.4 0.1 0.56 10.1 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.1 CCF45132.1 - 0.0004 20.4 1.2 0.37 10.7 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain Arch_ATPase PF01637.13 CCF45132.1 - 0.00044 20.0 0.1 0.025 14.3 0.0 2.4 2 0 0 2 2 2 1 Archaeal ATPase AAA_22 PF13401.1 CCF45132.1 - 0.00055 20.0 0.4 0.64 10.1 0.0 3.0 3 0 0 3 3 2 1 AAA domain Dynamin_N PF00350.18 CCF45132.1 - 0.0011 18.8 2.3 0.55 10.0 0.0 2.7 3 0 0 3 3 2 2 Dynamin family FtsK_SpoIIIE PF01580.13 CCF45132.1 - 0.0016 17.9 1.0 0.11 11.9 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_17 PF13207.1 CCF45132.1 - 0.0032 18.2 0.1 4.8 8.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.1 CCF45132.1 - 0.006 15.6 0.0 0.028 13.4 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain TrwB_AAD_bind PF10412.4 CCF45132.1 - 0.0071 15.0 0.3 1.2 7.6 0.0 2.4 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain NB-ARC PF00931.17 CCF45132.1 - 0.0077 15.1 0.8 0.1 11.4 0.1 2.7 2 1 0 2 2 2 1 NB-ARC domain Adeno_IVa2 PF02456.10 CCF45132.1 - 0.0086 14.7 0.1 0.13 10.9 0.0 2.1 2 0 0 2 2 2 1 Adenovirus IVa2 protein AAA_18 PF13238.1 CCF45132.1 - 0.01 16.1 0.2 8 6.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 CCF45132.1 - 0.015 14.4 0.1 5.7 5.9 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin DUF87 PF01935.12 CCF45132.1 - 0.016 15.0 0.8 0.22 11.2 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_19 PF13245.1 CCF45132.1 - 0.019 14.7 0.1 0.28 10.9 0.0 2.7 2 0 0 2 2 2 0 Part of AAA domain Mg_chelatase PF01078.16 CCF45132.1 - 0.02 14.0 0.0 3.5 6.7 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.1 CCF45132.1 - 0.02 14.7 0.0 0.72 9.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.10 CCF45132.1 - 0.044 12.4 0.0 0.071 11.7 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein NACHT PF05729.7 CCF45132.1 - 0.047 13.3 0.5 6.9 6.2 0.1 2.5 2 0 0 2 2 2 0 NACHT domain AAA PF00004.24 CCF45132.1 - 0.06 13.5 0.2 0.28 11.3 0.0 2.2 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.4 CCF45132.1 - 0.064 12.7 0.6 9.5 5.7 0.0 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Viral_helicase1 PF01443.13 CCF45132.1 - 0.074 12.5 0.2 2.8 7.4 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.1 CCF45132.1 - 0.076 12.8 0.0 5.7 6.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.8 CCF45132.1 - 0.077 11.8 0.0 7.2 5.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) RNA_helicase PF00910.17 CCF45132.1 - 0.082 13.0 0.0 8.3 6.6 0.0 2.7 2 0 0 2 2 2 0 RNA helicase cobW PF02492.14 CCF45132.1 - 0.098 12.0 2.4 2.6 7.4 0.2 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.9 CCF45132.1 - 0.24 11.0 0.9 3.5 7.3 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.1 CCF45132.1 - 0.3 10.6 0.1 28 4.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain Ribosomal_L28e PF01778.12 CCF45133.1 - 7.5e-21 74.7 0.8 1e-20 74.2 0.6 1.2 1 0 0 1 1 1 1 Ribosomal L28e protein family Potassium_chann PF11404.3 CCF45133.1 - 0.09 12.5 3.2 3.7 7.4 0.2 2.5 2 0 0 2 2 2 0 Potassium voltage-gated channel zf-DHHC PF01529.15 CCF45134.1 - 9.4 5.5 6.4 11 5.3 0.0 2.2 1 1 1 2 2 2 0 DHHC palmitoyltransferase NAD_binding_8 PF13450.1 CCF45138.1 - 8.6e-08 32.0 0.2 2.3e-07 30.7 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 CCF45138.1 - 4.5e-06 26.0 0.2 2.7e-05 23.4 0.1 2.0 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.1 CCF45138.1 - 8.6e-05 22.6 0.1 0.00034 20.7 0.1 1.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 CCF45138.1 - 0.00081 18.5 0.7 0.0021 17.2 0.2 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CCF45138.1 - 0.00094 18.1 1.7 0.0015 17.4 1.2 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 CCF45138.1 - 0.019 14.0 0.1 0.031 13.3 0.1 1.2 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.9 CCF45138.1 - 0.02 14.7 0.1 0.039 13.8 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF45138.1 - 0.022 13.6 0.5 0.047 12.5 0.3 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.9 CCF45138.1 - 0.026 12.9 0.4 0.039 12.4 0.3 1.1 1 0 0 1 1 1 0 HI0933-like protein DUF3328 PF11807.3 CCF45139.1 - 2.8e-14 53.3 0.1 3.3e-14 53.0 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) UBA PF00627.26 CCF45140.1 - 1.5e-07 31.0 0.0 2.5e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain ketoacyl-synt PF00109.21 CCF45141.1 - 3.7e-72 242.8 0.0 8.7e-72 241.6 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 CCF45141.1 - 7.4e-51 173.3 0.0 1.4e-50 172.4 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain Thioesterase PF00975.15 CCF45141.1 - 5.7e-47 160.8 0.0 1.8e-46 159.2 0.0 1.9 2 0 0 2 2 2 1 Thioesterase domain Ketoacyl-synt_C PF02801.17 CCF45141.1 - 1.3e-35 121.8 0.6 3.1e-35 120.5 0.4 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.20 CCF45141.1 - 9.8e-21 73.8 4.3 2.1e-10 40.6 0.2 2.6 2 0 0 2 2 2 2 Phosphopantetheine attachment site PS-DH PF14765.1 CCF45141.1 - 6.1e-19 68.2 0.8 1.2e-18 67.2 0.0 1.9 2 0 0 2 2 2 1 Polyketide synthase dehydratase Abhydrolase_5 PF12695.2 CCF45141.1 - 2e-06 27.6 0.2 0.18 11.5 0.0 3.4 3 0 0 3 3 3 2 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF45141.1 - 2.7e-06 27.4 1.8 0.0021 17.9 0.0 3.5 3 0 0 3 3 3 1 Alpha/beta hydrolase family Thiolase_N PF00108.18 CCF45141.1 - 0.00086 18.3 0.1 0.002 17.1 0.1 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain Ribosomal_60s PF00428.14 CCF45141.1 - 0.016 15.6 11.4 0.096 13.0 5.2 2.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein JAB PF01398.16 CCF45142.1 - 9.5e-27 93.0 0.0 1.3e-26 92.6 0.0 1.2 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 CCF45142.1 - 3.7e-07 29.6 0.0 5.1e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.8 CCF45142.1 - 0.071 12.5 0.0 0.1 12.0 0.0 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0172) DUF1183 PF06682.7 CCF45145.1 - 0.00073 19.2 0.1 0.00096 18.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1183) Tetraspannin PF00335.15 CCF45145.1 - 0.00094 18.5 0.5 0.0014 18.0 0.3 1.2 1 0 0 1 1 1 1 Tetraspanin family Shisa PF13908.1 CCF45145.1 - 0.0081 16.3 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Sensor PF13796.1 CCF45145.1 - 0.0085 15.7 0.1 0.0085 15.7 0.0 1.6 1 1 1 2 2 2 1 Putative sensor Herpes_gE PF02480.11 CCF45145.1 - 0.062 11.5 0.0 0.078 11.2 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Tmemb_185A PF10269.4 CCF45145.1 - 0.076 12.6 0.2 0.094 12.2 0.1 1.1 1 0 0 1 1 1 0 Transmembrane Fragile-X-F protein GP41 PF00517.12 CCF45145.1 - 0.083 12.4 0.1 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 Retroviral envelope protein Prominin PF05478.6 CCF45145.1 - 0.15 9.5 0.5 0.18 9.3 0.3 1.0 1 0 0 1 1 1 0 Prominin Synaptobrevin PF00957.16 CCF45145.1 - 0.43 10.2 3.6 0.65 9.6 2.5 1.2 1 0 0 1 1 1 0 Synaptobrevin LSR PF05624.9 CCF45145.1 - 0.51 10.1 4.5 0.91 9.3 3.1 1.3 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) DUF2668 PF10873.3 CCF45145.1 - 7.4 6.7 9.7 17 5.5 6.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2668) Enolase_C PF00113.17 CCF45150.1 - 4.4e-151 501.9 0.2 5.6e-151 501.5 0.1 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 CCF45150.1 - 2.4e-57 192.5 0.2 4.3e-57 191.7 0.1 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MAAL_C PF07476.6 CCF45150.1 - 0.0034 16.3 0.3 0.062 12.2 0.1 2.3 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus MR_MLE PF01188.16 CCF45150.1 - 0.051 14.1 0.0 0.13 12.8 0.0 1.7 1 0 0 1 1 1 0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain DUF3356 PF11836.3 CCF45150.1 - 0.088 12.6 0.1 0.26 11.1 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3356) Pec_lyase_C PF00544.14 CCF45151.1 - 1.9e-43 148.2 8.3 2.7e-43 147.7 5.7 1.1 1 0 0 1 1 1 1 Pectate lyase MFS_1 PF07690.11 CCF45152.1 - 6.3e-27 94.2 19.1 6.3e-27 94.2 13.2 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily YcxB PF14317.1 CCF45152.1 - 0.038 13.2 0.1 0.091 12.0 0.0 1.6 1 0 0 1 1 1 0 YcxB-like protein VIT1 PF01988.14 CCF45152.1 - 0.048 13.1 1.4 0.1 12.0 0.3 1.9 1 1 0 1 1 1 0 VIT family DUF4231 PF14015.1 CCF45152.1 - 0.47 10.4 0.1 0.47 10.4 0.0 3.8 4 1 1 5 5 5 0 Protein of unknown function (DUF4231) 60KD_IMP PF02096.15 CCF45152.1 - 0.79 9.3 6.4 0.95 9.0 0.2 2.7 2 1 1 3 3 3 0 60Kd inner membrane protein Glycos_transf_2 PF00535.21 CCF45155.1 - 1.2e-23 83.6 0.0 2.1e-23 82.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 CCF45155.1 - 1.1e-10 41.7 0.2 1.9e-07 31.1 0.0 2.9 3 0 0 3 3 3 2 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 CCF45155.1 - 0.0043 16.1 0.0 0.0063 15.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.1 CCF45155.1 - 0.0084 16.4 0.0 0.017 15.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 DND1_DSRM PF14709.1 CCF45156.1 - 0.00011 22.4 0.1 0.00031 20.9 0.0 1.8 2 1 0 2 2 2 1 double strand RNA binding domain from DEAD END PROTEIN 1 dsrm PF00035.20 CCF45156.1 - 0.0019 18.7 0.0 0.0048 17.4 0.0 1.7 2 0 0 2 2 2 1 Double-stranded RNA binding motif DUF755 PF05501.6 CCF45156.1 - 1.8 8.6 13.5 2.5 8.1 9.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF755) bZIP_1 PF00170.16 CCF45157.1 - 0.67 9.9 7.4 2 8.4 4.1 2.2 1 1 1 2 2 2 0 bZIP transcription factor Glyco_hydro_3_C PF01915.17 CCF45158.1 - 2.8e-72 242.9 0.1 5e-72 242.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 CCF45158.1 - 3.4e-24 84.5 2.6 1.5e-23 82.5 0.4 2.3 2 0 0 2 2 2 1 Fibronectin type III-like domain PA14 PF07691.7 CCF45158.1 - 1.6e-17 63.5 0.0 2.9e-17 62.6 0.0 1.5 1 0 0 1 1 1 1 PA14 domain CARDB PF07705.6 CCF45158.1 - 0.11 12.5 0.1 0.31 11.1 0.0 1.8 2 0 0 2 2 2 0 CARDB Lipase_GDSL_2 PF13472.1 CCF45158.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family DUF2393 PF09624.5 CCF45158.1 - 0.22 11.0 0.4 0.95 8.9 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2393) MitMem_reg PF13012.1 CCF45160.1 - 2.9e-15 56.3 0.0 5.1e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Abhydrolase_3 PF07859.8 CCF45160.1 - 0.039 13.5 0.0 0.049 13.1 0.0 1.1 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF4407 PF14362.1 CCF45160.1 - 0.17 10.8 5.2 0.19 10.6 3.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OAD_gamma PF04277.8 CCF45160.1 - 0.18 12.2 2.4 0.34 11.3 1.7 1.5 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain TRAP_alpha PF03896.11 CCF45160.1 - 0.51 9.2 4.0 0.58 9.1 2.8 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF809 PF05663.6 CCF45160.1 - 0.53 10.2 5.3 0.67 9.8 3.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF809) Bap31 PF05529.7 CCF45160.1 - 4.6 6.6 5.7 5.7 6.3 4.0 1.1 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like SWIM PF04434.12 CCF45161.1 - 0.003 16.9 0.5 0.29 10.6 0.0 2.4 2 0 0 2 2 2 2 SWIM zinc finger Coprogen_oxidas PF01218.13 CCF45162.1 - 2.3e-41 141.2 0.0 2.6e-41 141.0 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase DUF1651 PF07864.6 CCF45162.1 - 0.0027 17.7 0.3 0.042 13.9 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1651) Kelch_5 PF13854.1 CCF45163.1 - 1.9e-14 53.2 9.8 2.8e-07 30.3 0.1 4.8 4 1 0 4 4 4 4 Kelch motif Kelch_3 PF13415.1 CCF45163.1 - 9.6e-12 44.7 10.5 3.6e-06 26.9 0.0 5.1 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.1 CCF45163.1 - 4.8e-09 35.9 5.0 0.083 13.1 0.0 5.3 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.1 CCF45163.1 - 1e-07 31.6 9.5 0.33 10.7 0.0 5.7 4 1 1 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.20 CCF45163.1 - 0.17 11.4 5.5 21 4.7 0.1 4.3 5 0 0 5 5 5 0 Kelch motif Kelch_2 PF07646.10 CCF45163.1 - 0.2 11.4 5.3 4.3 7.2 0.0 4.3 6 0 0 6 6 6 0 Kelch motif CDC45 PF02724.9 CCF45163.1 - 9.7 4.0 9.9 13 3.6 6.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Amidohydro_1 PF01979.15 CCF45164.1 - 2.5e-40 139.1 0.0 3.6e-40 138.6 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 CCF45164.1 - 3.9e-07 29.6 5.7 8.7e-06 25.1 0.1 3.1 3 1 0 3 3 3 2 Amidohydrolase family Amidohydro_4 PF13147.1 CCF45164.1 - 1.1e-05 25.6 0.3 0.039 13.9 0.1 2.5 2 0 0 2 2 2 2 Amidohydrolase Amidohydro_5 PF13594.1 CCF45164.1 - 1.1e-05 25.1 0.0 4.4e-05 23.2 0.0 2.1 2 0 0 2 2 2 1 Amidohydrolase Lipase_GDSL PF00657.17 CCF45164.1 - 0.14 11.9 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Ank_2 PF12796.2 CCF45165.1 - 5e-56 187.0 0.7 8.3e-16 58.1 0.0 6.0 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 CCF45165.1 - 1.2e-53 176.3 2.0 3.5e-08 32.8 0.0 9.3 9 0 0 9 9 9 9 Ankyrin repeat Ank_5 PF13857.1 CCF45165.1 - 6.2e-37 124.7 5.1 1.3e-07 31.5 0.0 7.8 2 2 7 9 9 9 7 Ankyrin repeats (many copies) Ank_4 PF13637.1 CCF45165.1 - 1.6e-34 117.6 0.3 9.8e-06 25.9 0.0 5.8 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF45165.1 - 1.8e-34 114.2 0.0 4e-05 23.4 0.0 9.2 9 0 0 9 9 9 6 Ankyrin repeat zf-UBR PF02207.15 CCF45165.1 - 0.0066 16.1 0.8 0.012 15.2 0.6 1.4 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) C1_3 PF07649.7 CCF45165.1 - 0.077 13.0 8.8 0.15 12.1 6.1 1.5 1 0 0 1 1 1 0 C1-like domain ZZ PF00569.12 CCF45165.1 - 0.088 12.3 8.6 0.18 11.3 6.0 1.4 1 0 0 1 1 1 0 Zinc finger, ZZ type Cupin_2 PF07883.6 CCF45166.1 - 2.1e-08 33.5 0.0 3.6e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.17 CCF45166.1 - 0.0068 15.8 0.0 0.0099 15.3 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_6 PF12852.2 CCF45166.1 - 0.02 14.5 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 Cupin Abhydrolase_6 PF12697.2 CCF45167.1 - 6.4e-10 39.3 1.1 1.3e-09 38.2 0.8 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF45167.1 - 0.0031 17.1 0.0 0.0049 16.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_8 PF06259.7 CCF45167.1 - 0.09 12.2 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase TrbC PF04956.8 CCF45167.1 - 0.34 10.9 1.3 0.65 10.0 0.9 1.4 1 0 0 1 1 1 0 TrbC/VIRB2 family UbiA PF01040.13 CCF45169.1 - 2.2e-30 105.7 21.5 3.3e-30 105.1 14.5 1.6 1 1 0 1 1 1 1 UbiA prenyltransferase family CLN3 PF02487.12 CCF45172.1 - 4.9e-53 180.3 0.7 5.6e-53 180.1 0.5 1.0 1 0 0 1 1 1 1 CLN3 protein GTP_EFTU_D3 PF03143.12 CCF45173.1 - 4.5e-36 123.0 0.0 1.1e-35 121.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU PF00009.22 CCF45173.1 - 6.5e-20 71.3 0.0 1.1e-19 70.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.20 CCF45173.1 - 1e-17 63.9 2.0 1.5e-17 63.4 0.7 1.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 CCF45173.1 - 0.00043 19.8 0.2 0.0011 18.6 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 4 NmrA PF05368.8 CCF45174.1 - 1.1e-38 132.7 0.0 1.4e-38 132.4 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF45174.1 - 6.2e-23 81.7 0.0 8.2e-23 81.3 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 CCF45174.1 - 2.6e-06 26.3 0.4 1.1e-05 24.2 0.3 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 CCF45174.1 - 5.8e-05 22.6 0.0 0.00041 19.8 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.12 CCF45174.1 - 0.018 15.4 0.0 0.044 14.2 0.0 1.8 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.11 CCF45174.1 - 0.037 13.4 0.0 0.063 12.7 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF3042 PF11240.3 CCF45174.1 - 0.13 12.1 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) RNase_P_Rpp14 PF01900.14 CCF45176.1 - 1.3e-32 111.8 0.0 1.7e-32 111.5 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family ATP_bind_1 PF03029.12 CCF45177.1 - 3.9e-77 259.0 0.0 5e-77 258.6 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein ArgK PF03308.11 CCF45177.1 - 0.0032 16.3 0.2 0.0085 14.9 0.0 1.6 2 0 0 2 2 2 1 ArgK protein AAA_10 PF12846.2 CCF45177.1 - 0.0073 15.7 0.0 0.038 13.4 0.0 2.0 1 1 0 1 1 1 1 AAA-like domain AAA_29 PF13555.1 CCF45177.1 - 0.016 14.7 0.0 0.031 13.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain CbiA PF01656.18 CCF45177.1 - 0.037 13.4 0.0 0.091 12.1 0.0 1.7 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain GTP_EFTU PF00009.22 CCF45177.1 - 0.056 12.8 0.0 0.28 10.5 0.0 2.1 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_33 PF13671.1 CCF45177.1 - 0.074 12.9 0.3 0.16 11.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 CCF45177.1 - 0.1 13.4 2.7 0.47 11.2 1.9 2.4 1 1 0 1 1 1 0 AAA domain Fer4_NifH PF00142.13 CCF45177.1 - 0.16 11.1 0.2 4.4 6.4 0.1 2.2 1 1 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family cNMP_binding PF00027.24 CCF45178.1 - 2.6e-38 129.7 0.1 2.6e-18 65.6 0.0 4.6 4 0 0 4 4 4 3 Cyclic nucleotide-binding domain Patatin PF01734.17 CCF45178.1 - 1.6e-15 57.5 3.9 3.9e-14 53.0 2.7 2.8 1 1 0 1 1 1 1 Patatin-like phospholipase TraG_N PF07916.6 CCF45178.1 - 1.1 7.5 7.6 1.7 6.9 5.3 1.2 1 0 0 1 1 1 0 TraG-like protein, N-terminal region DUF2628 PF10947.3 CCF45178.1 - 1.7 8.4 4.8 3.8 7.3 3.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) MIP-T3 PF10243.4 CCF45179.1 - 8.6 4.6 12.0 10 4.4 8.3 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Pyridoxal_deC PF00282.14 CCF45180.1 - 2.1e-68 230.4 0.0 2.6e-68 230.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain CHORD PF04968.7 CCF45181.1 - 3.4e-51 171.3 16.5 1.1e-25 89.6 3.1 2.2 2 0 0 2 2 2 2 CHORD CS PF04969.11 CCF45181.1 - 1.7e-13 50.9 0.0 2.7e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 CS domain DUF4526 PF15029.1 CCF45183.1 - 1 8.8 6.2 0.051 13.1 0.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4526) TruB_C PF09142.6 CCF45184.1 - 0.052 13.2 0.3 12 5.6 0.0 3.0 3 0 0 3 3 3 0 tRNA Pseudouridine synthase II, C terminal DUF3425 PF11905.3 CCF45185.1 - 7.9e-05 22.5 0.1 0.0023 17.8 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3425) DivIC PF04977.10 CCF45185.1 - 1.5 8.3 3.9 3.4 7.2 2.7 1.6 1 0 0 1 1 1 0 Septum formation initiator Chromate_transp PF02417.10 CCF45186.1 - 3.1e-28 98.5 13.6 3.1e-28 98.5 9.4 1.7 2 0 0 2 2 2 1 Chromate transporter DUF4066 PF13278.1 CCF45188.1 - 0.0034 16.6 0.0 0.0038 16.4 0.0 1.1 1 0 0 1 1 1 1 Putative amidotransferase EnY2 PF10163.4 CCF45190.1 - 0.032 14.1 0.1 0.052 13.4 0.0 1.3 1 0 0 1 1 1 0 Transcription factor e(y)2 SusD PF07980.6 CCF45190.1 - 0.09 12.2 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 SusD family MFS_1 PF07690.11 CCF45193.1 - 5.8e-28 97.6 28.6 2.9e-21 75.5 12.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3099 PF11298.3 CCF45193.1 - 0.063 13.0 0.0 0.23 11.2 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3099) ATG22 PF11700.3 CCF45193.1 - 0.088 11.2 10.0 0.2 10.0 6.9 1.6 1 1 0 1 1 1 0 Vacuole effluxer Atg22 like OATP PF03137.15 CCF45193.1 - 0.1 10.6 0.0 4.9 5.0 0.0 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF2975 PF11188.3 CCF45193.1 - 0.12 12.1 1.7 0.45 10.2 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) Dioxygenase_C PF00775.16 CCF45195.1 - 1e-11 44.4 2.6 1e-10 41.2 1.8 2.1 1 1 0 1 1 1 1 Dioxygenase KdpC PF02669.10 CCF45195.1 - 0.27 10.8 2.2 3.1 7.4 0.0 2.4 2 0 0 2 2 2 0 K+-transporting ATPase, c chain DUF1996 PF09362.5 CCF45197.1 - 3.2e-48 164.4 0.2 4.2e-48 164.0 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) Sugar_tr PF00083.19 CCF45198.1 - 1.9e-15 56.4 8.3 2.4e-15 56.0 5.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF45198.1 - 2.7e-11 42.8 9.3 2.8e-11 42.7 6.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF45198.1 - 0.0034 15.8 1.5 0.0039 15.6 1.1 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1_like PF12832.2 CCF45198.1 - 0.01 15.6 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 MFS_1 like family OATP PF03137.15 CCF45198.1 - 0.038 12.0 3.8 0.054 11.5 2.1 1.6 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Ank_2 PF12796.2 CCF45200.1 - 1.3e-56 188.8 0.8 1.4e-12 47.7 0.0 5.6 4 1 2 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 CCF45200.1 - 2.8e-39 130.9 5.2 4.3e-06 26.2 0.0 11.4 11 0 0 11 11 11 9 Ankyrin repeat Ank_4 PF13637.1 CCF45200.1 - 3e-34 116.7 3.9 1.6e-06 28.4 0.0 9.5 5 4 5 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF45200.1 - 4.8e-32 106.8 2.5 0.00022 21.1 0.0 11.3 12 1 1 13 13 13 7 Ankyrin repeat Ank_5 PF13857.1 CCF45200.1 - 9.7e-32 108.2 5.1 3.8e-08 33.3 0.0 8.3 6 4 3 9 9 9 7 Ankyrin repeats (many copies) Ribosomal_L7Ae PF01248.21 CCF45200.1 - 0.022 14.2 0.0 0.9 9.0 0.0 2.5 2 0 0 2 2 2 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Metallophos_2 PF12850.2 CCF45202.1 - 2.3e-13 50.2 0.0 2.8e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 CCF45202.1 - 0.12 11.7 0.1 1.6 8.0 0.0 2.1 1 1 0 2 2 2 0 Calcineurin-like phosphoesterase Shugoshin_C PF07557.6 CCF45203.1 - 7.1e-12 44.5 7.0 7.1e-12 44.5 4.8 3.2 3 0 0 3 3 3 1 Shugoshin C terminus Shugoshin_N PF07558.6 CCF45203.1 - 0.002 17.7 1.6 0.0047 16.5 1.1 1.6 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region DASH_Dad2 PF08654.5 CCF45204.1 - 4e-33 113.4 0.7 5.8e-33 112.9 0.5 1.3 1 0 0 1 1 1 1 DASH complex subunit Dad2 AAA_27 PF13514.1 CCF45204.1 - 0.0046 14.7 0.6 0.0052 14.5 0.4 1.0 1 0 0 1 1 1 1 AAA domain Seryl_tRNA_N PF02403.17 CCF45204.1 - 0.014 15.4 0.9 0.018 15.0 0.1 1.6 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain COesterase PF00135.23 CCF45206.1 - 6.5e-78 262.7 0.0 7.4e-78 262.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF45206.1 - 1.3e-06 28.1 1.2 5.4e-06 26.1 0.8 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF45206.1 - 0.064 13.0 0.1 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family zf-HYPF PF07503.7 CCF45207.1 - 0.00078 18.8 0.8 0.002 17.5 0.6 1.7 1 0 0 1 1 1 1 HypF finger FYDLN_acid PF09538.5 CCF45207.1 - 0.092 13.3 0.1 0.29 11.7 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF2225 PF09986.4 CCF45207.1 - 0.16 11.3 0.4 0.25 10.7 0.3 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) Rad50_zn_hook PF04423.9 CCF45207.1 - 0.23 10.9 0.5 0.45 10.0 0.3 1.4 1 0 0 1 1 1 0 Rad50 zinc hook motif PMP1_2 PF08114.6 CCF45207.1 - 0.27 10.7 3.8 0.29 10.6 0.1 2.2 2 0 0 2 2 2 0 ATPase proteolipid family DUF2305 PF10230.4 CCF45209.1 - 6.7e-59 199.4 0.0 8.6e-59 199.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Abhydrolase_6 PF12697.2 CCF45209.1 - 8.4e-09 35.6 1.1 1.1e-08 35.3 0.7 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF45209.1 - 0.0058 16.3 0.0 0.012 15.3 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Oxidored_molyb PF00174.14 CCF45210.1 - 3.4e-51 173.0 0.0 4.6e-51 172.5 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.11 CCF45210.1 - 1.9e-31 108.3 0.7 3.5e-31 107.5 0.5 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain BNR_2 PF13088.1 CCF45210.1 - 0.013 14.7 0.2 0.023 14.0 0.1 1.3 1 0 0 1 1 1 0 BNR repeat-like domain BNR PF02012.15 CCF45210.1 - 0.017 14.8 0.2 0.065 13.0 0.1 2.0 1 0 0 1 1 1 0 BNR/Asp-box repeat ADH_N PF08240.7 CCF45212.1 - 3.2e-10 39.7 0.0 8.5e-09 35.1 0.0 2.1 1 1 1 2 2 2 2 Alcohol dehydrogenase GroES-like domain Epimerase PF01370.16 CCF45213.1 - 5.5e-19 68.5 0.0 6.8e-19 68.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF45213.1 - 7e-15 54.4 0.0 5e-14 51.6 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 CCF45213.1 - 1e-12 48.4 0.2 2.6e-12 47.1 0.2 1.8 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 CCF45213.1 - 1.8e-10 40.2 0.0 8.2e-10 38.0 0.0 1.8 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 CCF45213.1 - 6.4e-08 32.6 1.3 9e-08 32.2 0.1 1.7 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 CCF45213.1 - 3.6e-07 30.0 0.1 6.2e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 KR domain NmrA PF05368.8 CCF45213.1 - 0.00091 18.5 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.12 CCF45213.1 - 0.003 16.4 0.0 0.0058 15.5 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain ApbA PF02558.11 CCF45213.1 - 0.013 14.9 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.12 CCF45213.1 - 0.032 14.6 0.0 0.064 13.6 0.0 1.6 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Herpes_teg_N PF04843.7 CCF45213.1 - 0.084 12.2 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus tegument protein, N-terminal conserved region DUF1162 PF06650.7 CCF45214.1 - 1.6e-10 40.6 0.0 1.2e-05 24.6 0.0 3.8 4 0 0 4 4 4 2 Protein of unknown function (DUF1162) zf-C2H2 PF00096.21 CCF45216.1 - 0.00015 21.8 18.6 0.0021 18.3 0.3 4.2 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_2 PF12756.2 CCF45216.1 - 0.013 15.6 1.5 0.04 14.0 1.1 1.8 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.1 CCF45216.1 - 0.03 14.6 1.0 0.03 14.6 0.7 4.7 5 0 0 5 5 5 0 C2H2-type zinc finger DUF202 PF02656.10 CCF45217.1 - 0.0012 19.0 2.9 0.0012 19.0 2.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF202) AT_hook PF02178.14 CCF45218.1 - 0.077 12.7 3.8 0.23 11.2 2.6 1.8 1 0 0 1 1 1 0 AT hook motif WD40 PF00400.27 CCF45219.1 - 7.3e-36 120.7 7.8 1.5e-13 50.0 0.1 4.3 4 0 0 4 4 4 4 WD domain, G-beta repeat NLE PF08154.7 CCF45219.1 - 0.00093 19.1 0.0 0.0016 18.4 0.0 1.3 1 0 0 1 1 1 1 NLE (NUC135) domain DUF4079 PF13301.1 CCF45220.1 - 0.013 15.4 0.3 0.022 14.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) DUF2427 PF10348.4 CCF45220.1 - 0.043 13.3 6.2 0.035 13.6 1.7 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF2427) CopD PF05425.8 CCF45220.1 - 0.095 12.9 0.3 0.095 12.9 0.2 1.8 2 0 0 2 2 2 0 Copper resistance protein D Gelsolin PF00626.17 CCF45221.1 - 9.3e-05 22.0 0.0 0.00023 20.7 0.0 1.7 2 0 0 2 2 2 1 Gelsolin repeat NapD PF03927.8 CCF45221.1 - 0.11 12.3 0.0 13 5.7 0.0 2.2 2 0 0 2 2 2 0 NapD protein Cut8_C PF08559.5 CCF45222.1 - 1.3e-44 151.5 0.0 1.6e-44 151.1 0.0 1.1 1 0 0 1 1 1 1 Cut8 six-helix bundle Cut8_M PF14483.1 CCF45222.1 - 2.6e-12 46.3 0.5 5e-12 45.4 0.3 1.5 1 0 0 1 1 1 1 Cut8 dimerisation domain Cut8_N PF14482.1 CCF45222.1 - 1.7e-07 31.1 5.6 3.9e-07 29.9 3.9 1.6 1 0 0 1 1 1 1 Cut8 proteasome-binding domain Rdx PF10262.4 CCF45223.1 - 1.7e-29 101.6 0.0 2.6e-29 101.0 0.0 1.3 1 0 0 1 1 1 1 Rdx family Dimerisation PF08100.6 CCF45223.1 - 0.11 12.3 0.2 0.28 11.0 0.2 1.6 1 0 0 1 1 1 0 Dimerisation domain 2_5_RNA_ligase2 PF13563.1 CCF45225.1 - 4e-31 107.8 0.0 1e-30 106.4 0.0 1.8 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily PAP_central PF04928.12 CCF45225.1 - 1.1e-21 76.8 0.0 2.5e-21 75.6 0.0 1.5 1 0 0 1 1 1 1 Poly(A) polymerase central domain Exo_endo_phos PF03372.18 CCF45225.1 - 1.7e-15 57.6 0.2 4.4e-15 56.3 0.1 1.8 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family DUF504 PF04457.7 CCF45225.1 - 1.8e-08 34.3 0.3 3.9e-08 33.3 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF504) NTP_transf_2 PF01909.18 CCF45225.1 - 0.00017 21.8 0.0 0.00047 20.4 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_RNA-bind PF04926.10 CCF45225.1 - 0.00025 20.6 0.0 0.00042 19.8 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain LigT_PEase PF02834.11 CCF45225.1 - 0.016 15.1 0.0 0.13 12.2 0.0 2.5 3 0 0 3 3 3 0 LigT like Phosphoesterase Exo70 PF03081.10 CCF45226.1 - 1.1e-69 234.9 0.0 1.3e-69 234.8 0.0 1.0 1 0 0 1 1 1 1 Exo70 exocyst complex subunit Apolipoprotein PF01442.13 CCF45226.1 - 0.15 11.5 0.3 0.37 10.2 0.1 1.8 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain MFS_1 PF07690.11 CCF45227.1 - 5.7e-29 100.9 40.2 9.6e-18 64.0 15.9 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily AAA PF00004.24 CCF45228.1 - 1.7e-22 80.0 0.0 1.8e-20 73.5 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 CCF45228.1 - 4.7e-06 25.8 0.0 8.7e-06 24.9 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 CCF45228.1 - 0.001 19.8 0.0 0.0032 18.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.8 CCF45228.1 - 0.0061 15.5 0.0 0.0092 14.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.1 CCF45228.1 - 0.0062 16.8 0.0 0.012 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 CCF45228.1 - 0.0082 15.8 0.0 0.066 12.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 CCF45228.1 - 0.011 15.7 0.0 0.04 13.9 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.17 CCF45228.1 - 0.012 15.7 0.0 0.042 14.0 0.0 1.9 2 0 0 2 2 2 0 RNA helicase AAA_25 PF13481.1 CCF45228.1 - 0.024 14.0 0.0 0.039 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 CCF45228.1 - 0.054 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 CCF45228.1 - 0.066 12.6 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.8 CCF45228.1 - 0.077 11.7 0.0 0.13 10.9 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus AAA_19 PF13245.1 CCF45228.1 - 0.087 12.5 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain YL1_C PF08265.6 CCF45228.1 - 0.11 12.0 0.2 0.24 10.9 0.1 1.5 1 0 0 1 1 1 0 YL1 nuclear protein C-terminal domain Rhomboid PF01694.17 CCF45229.1 - 0.12 12.3 6.0 1.6 8.7 1.3 2.4 2 0 0 2 2 2 0 Rhomboid family YjgP_YjgQ PF03739.9 CCF45229.1 - 2.3 6.9 5.7 2.2 6.9 2.7 1.8 2 0 0 2 2 2 0 Predicted permease YjgP/YjgQ family Polysacc_deac_1 PF01522.16 CCF45230.1 - 5.6e-27 93.8 0.0 8.9e-27 93.1 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.14 CCF45230.1 - 2.9e-10 39.9 49.0 8.6e-06 25.6 12.9 3.3 3 0 0 3 3 3 2 Chitin recognition protein TRI5 PF06330.6 CCF45230.1 - 0.13 10.9 0.0 0.18 10.4 0.0 1.1 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) CHRD PF07452.7 CCF45231.1 - 0.009 16.6 0.0 0.023 15.2 0.0 1.8 2 0 0 2 2 2 1 CHRD domain Ank_2 PF12796.2 CCF45234.1 - 6.5e-32 109.7 0.0 1.9e-08 34.5 0.0 6.4 3 1 1 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 CCF45234.1 - 2.4e-24 83.8 19.6 5.3e-05 22.8 0.0 9.6 10 0 0 10 10 10 6 Ankyrin repeat Ank_3 PF13606.1 CCF45234.1 - 3.5e-20 70.0 10.9 0.083 13.1 0.0 10.8 11 0 0 11 11 11 6 Ankyrin repeat Ank_4 PF13637.1 CCF45234.1 - 5.1e-18 65.0 4.3 0.00018 21.8 0.1 7.4 6 1 1 7 7 7 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF45234.1 - 1.1e-15 57.2 10.4 0.00013 22.0 0.0 7.7 8 2 2 10 10 10 4 Ankyrin repeats (many copies) Aldo_ket_red PF00248.16 CCF45235.1 - 5.1e-66 222.3 0.0 6.3e-66 222.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Methyltransf_23 PF13489.1 CCF45236.1 - 2.8e-20 72.6 0.0 4.5e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF45236.1 - 2.2e-08 34.6 0.0 3.7e-07 30.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF45236.1 - 1e-06 29.1 0.0 3.2e-06 27.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF45236.1 - 8.3e-06 26.2 0.0 3e-05 24.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF45236.1 - 2e-05 24.2 0.0 0.00018 21.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF45236.1 - 0.00038 19.8 0.0 0.21 10.9 0.0 2.8 2 1 1 3 3 3 2 Methyltransferase small domain Methyltransf_4 PF02390.12 CCF45236.1 - 0.00058 18.9 0.2 0.16 11.0 0.0 2.6 3 0 0 3 3 3 2 Putative methyltransferase FtsJ PF01728.14 CCF45236.1 - 0.0056 16.6 0.0 0.0083 16.1 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_25 PF13649.1 CCF45236.1 - 0.041 14.2 0.0 0.12 12.8 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain FGE-sulfatase PF03781.11 CCF45239.1 - 1.1e-17 64.2 0.5 2.3e-10 40.2 0.1 2.5 2 1 0 2 2 2 2 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.2 CCF45239.1 - 2.3e-07 31.1 0.3 4.9e-07 30.1 0.2 1.6 1 0 0 1 1 1 1 DinB superfamily Trypsin_2 PF13365.1 CCF45241.1 - 8.2e-17 61.3 0.0 1.5e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_C4 PF00863.14 CCF45241.1 - 0.00052 19.0 0.0 0.0029 16.6 0.0 1.9 2 0 0 2 2 2 1 Peptidase family C4 Trypsin PF00089.21 CCF45241.1 - 0.012 15.1 0.0 1.4 8.4 0.0 2.3 2 0 0 2 2 2 0 Trypsin Peptidase_S46 PF10459.4 CCF45241.1 - 0.017 13.5 0.0 0.065 11.6 0.0 1.8 2 0 0 2 2 2 0 Peptidase S46 Peptidase_S32 PF05579.8 CCF45241.1 - 0.076 11.9 0.1 0.15 11.0 0.1 1.4 1 0 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 MIT PF04212.13 CCF45242.1 - 2.5e-13 49.6 1.8 3.6e-13 49.1 1.2 1.2 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain DUF3543 PF12063.3 CCF45242.1 - 0.23 10.6 1.5 0.31 10.1 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3543) SQS_PSY PF00494.14 CCF45243.1 - 0.028 13.7 0.1 0.038 13.2 0.1 1.2 1 0 0 1 1 1 0 Squalene/phytoene synthase SnoaL_2 PF12680.2 CCF45244.1 - 0.0092 16.3 0.8 0.017 15.5 0.6 1.5 1 1 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.1 CCF45244.1 - 0.036 13.9 2.9 0.063 13.1 2.0 1.4 1 1 0 1 1 1 0 SnoaL-like domain DHDPS PF00701.17 CCF45245.1 - 2e-45 154.6 0.0 2.4e-45 154.3 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family ubiquitin PF00240.18 CCF45248.1 - 1.5e-34 117.2 0.9 2.8e-34 116.3 0.6 1.5 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.14 CCF45248.1 - 3.1e-28 97.3 1.8 6.4e-28 96.3 1.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.3 CCF45248.1 - 5.4e-20 70.8 0.7 1.1e-19 69.9 0.5 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 CCF45248.1 - 8.6e-06 25.9 0.6 4.1e-05 23.7 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 CCF45248.1 - 0.00013 21.6 0.2 0.00021 21.0 0.0 1.4 1 1 0 1 1 1 1 Telomere stability and silencing Rad60-SLD_2 PF13881.1 CCF45248.1 - 0.0017 18.2 0.6 0.0035 17.1 0.4 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 CCF45248.1 - 0.0044 17.1 0.6 0.006 16.7 0.4 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain DUF2870 PF11069.3 CCF45248.1 - 0.047 13.7 1.0 0.07 13.1 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) Stig1 PF04885.8 CCF45248.1 - 0.069 13.3 0.2 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 Stigma-specific protein, Stig1 DUF971 PF06155.7 CCF45248.1 - 0.076 13.4 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF971) DUF2207 PF09972.4 CCF45248.1 - 0.088 11.3 0.4 0.094 11.2 0.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Plexin_cytopl PF08337.7 CCF45248.1 - 0.097 10.9 2.9 1.8 6.7 0.1 2.1 1 1 0 2 2 2 0 Plexin cytoplasmic RasGAP domain MFS_1 PF07690.11 CCF45249.1 - 1.8e-34 118.9 32.0 1.8e-34 118.9 22.2 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF1469 PF07332.6 CCF45249.1 - 1.8 8.2 0.0 1.8 8.2 0.0 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF1469) Phage_holin PF04688.8 CCF45249.1 - 4.9 6.7 7.0 33 4.1 4.8 2.5 1 0 0 1 1 1 0 Phage lysis protein, holin 4HBT_2 PF13279.1 CCF45251.1 - 1.5e-19 70.5 0.3 2.7e-19 69.7 0.2 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.17 CCF45251.1 - 0.0013 18.7 0.0 0.0027 17.7 0.0 1.5 1 0 0 1 1 1 1 Thioesterase superfamily ketoacyl-synt PF00109.21 CCF45252.1 - 3.1e-19 69.4 0.1 7.2e-19 68.2 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.15 CCF45252.1 - 7.6e-17 61.1 0.0 1.7e-16 60.0 0.0 1.7 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.17 CCF45252.1 - 7.2e-11 41.9 0.0 2.2e-10 40.4 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.20 CCF45252.1 - 5.7e-05 23.0 0.0 0.00019 21.3 0.0 2.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF45252.1 - 0.013 15.1 0.0 0.04 13.5 0.0 1.8 1 0 0 1 1 1 0 KR domain Acyl_transf_1 PF00698.16 CCF45254.1 - 7.5e-80 268.6 0.0 2.7e-78 263.4 0.0 2.9 3 0 0 3 3 3 1 Acyl transferase domain MaoC_dehydratas PF01575.14 CCF45254.1 - 5.6e-39 132.3 0.0 1.3e-38 131.1 0.0 1.6 1 0 0 1 1 1 1 MaoC like domain DUF1729 PF08354.5 CCF45254.1 - 2.7e-28 97.5 0.0 7.3e-28 96.1 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) MaoC_dehydrat_N PF13452.1 CCF45254.1 - 1e-22 80.3 0.1 7.5e-22 77.5 0.0 2.6 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase NMO PF03060.10 CCF45254.1 - 8.4e-07 28.4 0.6 6.7e-06 25.4 0.5 2.2 1 1 0 1 1 1 1 Nitronate monooxygenase PepSY_2 PF13670.1 CCF45255.1 - 0.22 11.4 0.5 2.1 8.3 0.4 2.1 1 1 0 1 1 1 0 Peptidase propeptide and YPEB domain MRP-L47 PF06984.8 CCF45257.1 - 1.1e-23 82.8 0.5 2e-23 82.1 0.3 1.4 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) DNA_ligase_A_M PF01068.16 CCF45260.1 - 2.5e-58 196.8 1.0 4.9e-47 159.9 0.2 2.2 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_C PF04679.10 CCF45260.1 - 2.7e-28 98.2 0.0 1.2e-27 96.1 0.0 2.1 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region DNA_ligase_A_N PF04675.9 CCF45260.1 - 7.9e-19 68.1 0.0 1.6e-18 67.1 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus mRNA_cap_enzyme PF01331.14 CCF45260.1 - 0.0081 15.8 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain DNA_ligase_OB_2 PF14743.1 CCF45260.1 - 0.095 12.3 1.1 12 5.6 0.0 3.1 3 0 0 3 3 3 0 DNA ligase OB-like domain TPP_enzyme_N PF02776.13 CCF45261.1 - 2.7e-34 118.1 0.0 4.5e-34 117.3 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 CCF45261.1 - 3.9e-26 91.4 0.0 8.3e-26 90.3 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 CCF45261.1 - 1.9e-16 59.9 0.2 1.6e-15 57.0 0.1 2.4 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.1 CCF45261.1 - 0.0022 16.9 0.0 0.0036 16.2 0.0 1.2 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.15 CCF45261.1 - 0.006 15.3 0.1 0.0095 14.6 0.1 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component OCC1 PF15506.1 CCF45261.1 - 0.76 9.6 2.8 30 4.5 0.3 3.0 3 0 0 3 3 3 0 OCC1 family THUMP PF02926.12 CCF45262.1 - 1.2e-08 34.9 3.2 2e-07 30.9 0.1 2.8 2 1 1 3 3 3 2 THUMP domain Prim_Zn_Ribbon PF08273.7 CCF45264.1 - 0.19 11.8 1.2 0.49 10.5 0.1 2.1 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase DUF2415 PF10313.4 CCF45267.1 - 2e-13 49.7 0.0 4.1e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) HET PF06985.6 CCF45269.1 - 2.3e-18 66.6 12.5 2.6e-17 63.2 1.2 2.8 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) CAP_C PF08603.6 CCF45272.1 - 1.3e-55 187.0 2.8 1.5e-55 186.8 2.0 1.0 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.7 CCF45272.1 - 0.029 13.7 2.7 0.11 11.9 1.1 1.9 1 1 0 2 2 2 0 Tubulin binding cofactor C Carn_acyltransf PF00755.15 CCF45273.1 - 5.4e-83 279.0 0.0 6.1e-83 278.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase PolyA_pol PF01743.15 CCF45274.1 - 1.9e-17 63.6 0.1 4.7e-17 62.3 0.1 1.7 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.2 CCF45274.1 - 1.1e-06 28.1 0.0 2.1e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.1 CCF45274.1 - 0.0011 18.8 0.0 0.0017 18.2 0.0 1.4 1 0 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative IncA PF04156.9 CCF45275.1 - 0.073 12.6 7.1 0.096 12.2 4.9 1.2 1 0 0 1 1 1 0 IncA protein Flu_B_M2 PF04772.7 CCF45275.1 - 0.11 12.6 0.3 0.19 11.7 0.2 1.3 1 0 0 1 1 1 0 Influenza B matrix protein 2 (BM2) Atg14 PF10186.4 CCF45275.1 - 0.15 11.0 10.2 0.2 10.5 7.1 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 FAA_hydrolase_N PF09298.6 CCF45275.1 - 0.38 10.7 2.7 0.82 9.6 1.9 1.6 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal DUF1104 PF06518.6 CCF45275.1 - 0.38 10.9 3.5 0.75 9.9 1.5 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1104) Allexi_40kDa PF05549.6 CCF45275.1 - 1.4 8.1 5.1 1.4 8.1 2.0 1.8 1 1 0 2 2 2 0 Allexivirus 40kDa protein GrpE PF01025.14 CCF45276.1 - 5.7e-08 32.4 0.0 6.3e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 GrpE NPR3 PF03666.8 CCF45277.1 - 0.12 10.9 0.1 0.12 10.9 0.1 1.7 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 AA_permease PF00324.16 CCF45280.1 - 8.9e-112 373.8 45.6 1.1e-111 373.5 31.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF45280.1 - 2e-36 125.4 46.6 2.4e-36 125.2 32.3 1.1 1 0 0 1 1 1 1 Amino acid permease ADH_zinc_N PF00107.21 CCF45281.1 - 3.3e-09 36.3 1.0 6e-09 35.5 0.7 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF45281.1 - 5.1e-05 22.9 0.0 9.3e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain TFIIF_alpha PF05793.7 CCF45283.1 - 3 6.1 43.5 0.46 8.8 0.9 3.1 3 0 0 3 3 3 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BSP_II PF05432.6 CCF45283.1 - 3.2 6.9 36.1 0.97 8.6 11.1 3.2 3 0 0 3 3 3 0 Bone sialoprotein II (BSP-II) BUD22 PF09073.5 CCF45283.1 - 6.2 5.7 42.8 1.1 8.3 24.6 2.2 2 0 0 2 2 2 0 BUD22 YibE_F PF07907.6 CCF45284.1 - 0.065 12.4 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 YibE/F-like protein peroxidase PF00141.18 CCF45286.1 - 7.1e-26 91.1 0.0 1e-25 90.5 0.0 1.2 1 0 0 1 1 1 1 Peroxidase XAP5 PF04921.9 CCF45288.1 - 4.2e-80 268.7 0.0 7.2e-80 267.9 0.0 1.3 1 0 0 1 1 1 1 XAP5, circadian clock regulator bZIP_1 PF00170.16 CCF45289.1 - 0.00019 21.3 18.0 0.0019 18.1 7.5 2.6 1 1 2 3 3 3 2 bZIP transcription factor DUF837 PF05769.6 CCF45289.1 - 0.0071 15.9 3.8 0.01 15.3 2.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF837) Atg14 PF10186.4 CCF45289.1 - 0.021 13.7 9.4 0.033 13.1 6.5 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4515 PF14988.1 CCF45289.1 - 0.023 14.3 7.3 0.036 13.7 5.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) LOH1CR12 PF10158.4 CCF45289.1 - 0.057 13.2 2.6 0.11 12.3 1.8 1.4 1 0 0 1 1 1 0 Tumour suppressor protein DUF3138 PF11336.3 CCF45289.1 - 0.066 11.3 0.2 0.14 10.2 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) Effector_1 PF04518.7 CCF45289.1 - 0.071 12.0 1.8 0.1 11.5 1.2 1.1 1 0 0 1 1 1 0 Effector from type III secretion system HALZ PF02183.13 CCF45289.1 - 0.079 12.6 0.9 0.21 11.3 0.6 1.7 1 0 0 1 1 1 0 Homeobox associated leucine zipper Mnd1 PF03962.10 CCF45289.1 - 0.15 11.7 3.9 0.29 10.7 2.7 1.5 1 0 0 1 1 1 0 Mnd1 family Mto2_bdg PF12808.2 CCF45289.1 - 0.15 12.1 12.1 0.049 13.7 4.2 2.9 2 1 1 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Jnk-SapK_ap_N PF09744.4 CCF45289.1 - 0.44 10.5 5.9 0.69 9.8 4.1 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 NARP1 PF12569.3 CCF45289.1 - 0.85 8.2 5.8 1.2 7.8 4.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Fib_alpha PF08702.5 CCF45289.1 - 0.98 9.5 6.4 1.1 9.3 3.5 1.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family SLX9 PF15341.1 CCF45289.1 - 1.9 8.9 10.6 6.3 7.2 4.7 2.3 1 1 1 2 2 2 0 Ribosome biogenesis protein SLX9 DUF4164 PF13747.1 CCF45289.1 - 2 8.5 15.4 0.97 9.6 2.8 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) Cu-oxidase_3 PF07732.10 CCF45290.1 - 3e-39 133.4 1.2 4.7e-39 132.7 0.8 1.3 1 0 0 1 1 1 1 Multicopper oxidase Avian_gp85 PF03708.9 CCF45291.1 - 0.0041 16.4 0.5 0.0047 16.2 0.3 1.1 1 0 0 1 1 1 1 Avian retrovirus envelope protein, gp85 AA_permease PF00324.16 CCF45293.1 - 2e-144 481.5 35.9 2.3e-144 481.3 24.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CCF45293.1 - 4.5e-40 137.4 40.3 6e-40 137.0 27.9 1.1 1 0 0 1 1 1 1 Amino acid permease DUF373 PF04123.8 CCF45293.1 - 7.6 5.4 8.3 23 3.8 5.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Abhydrolase_3 PF07859.8 CCF45296.1 - 2.2e-20 73.1 0.1 2.9e-20 72.7 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 CCF45296.1 - 5.2e-05 22.1 0.0 0.00028 19.7 0.0 1.8 2 0 0 2 2 2 1 Carboxylesterase family Abhydrolase_2 PF02230.11 CCF45296.1 - 0.044 13.2 0.0 0.067 12.6 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 CCF45296.1 - 0.053 13.2 0.0 0.088 12.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF45296.1 - 0.082 12.7 1.5 0.13 12.1 1.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF45296.1 - 0.14 11.3 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Ligase_CoA PF00549.14 CCF45298.1 - 1.5e-11 44.1 0.2 2.1e-11 43.6 0.1 1.2 1 0 0 1 1 1 1 CoA-ligase PsaL PF02605.10 CCF45298.1 - 0.075 12.5 0.0 0.081 12.4 0.0 1.2 1 0 0 1 1 1 0 Photosystem I reaction centre subunit XI Glyco_hydro_3_C PF01915.17 CCF45298.1 - 0.12 11.8 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain DUF2413 PF10310.4 CCF45299.1 - 1.4e-136 455.8 4.6 7.9e-136 453.3 3.2 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF2413) Flu_M1_C PF08289.6 CCF45299.1 - 0.033 14.2 0.3 0.089 12.8 0.2 1.7 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain EthD PF07110.6 CCF45300.1 - 1.2e-10 42.1 0.0 1.6e-10 41.7 0.0 1.1 1 0 0 1 1 1 1 EthD domain DUF1689 PF07954.6 CCF45301.1 - 0.15 11.9 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1689) DDE_1 PF03184.14 CCF45303.1 - 5.4e-60 202.2 0.0 1.5e-34 119.0 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease DDE_3 PF13358.1 CCF45303.1 - 2.6e-07 30.4 0.0 1.9e-06 27.6 0.0 2.4 1 1 0 1 1 1 1 DDE superfamily endonuclease RRN3 PF05327.6 CCF45304.1 - 2.1e-164 547.7 0.0 2.1e-164 547.7 0.0 1.6 1 1 1 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 DUF2372 PF10178.4 CCF45304.1 - 0.073 13.2 0.0 0.2 11.8 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2372) IBN_N PF03810.14 CCF45304.1 - 0.14 12.1 0.0 0.6 10.0 0.0 2.0 2 0 0 2 2 2 0 Importin-beta N-terminal domain CBFD_NFYB_HMF PF00808.18 CCF45305.1 - 1.6e-29 101.7 0.9 2.2e-29 101.3 0.6 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 CCF45305.1 - 2.7e-07 30.6 0.0 4.3e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.11 CCF45305.1 - 0.0012 18.6 0.0 0.0017 18.1 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Bromo_TP PF07524.8 CCF45305.1 - 0.0018 17.9 0.0 0.0032 17.1 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.8 CCF45305.1 - 0.053 13.8 0.0 0.09 13.0 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Herpes_LMP1 PF05297.6 CCF45305.1 - 4.7 6.0 10.4 1.1 8.0 0.5 2.0 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) Prefoldin_2 PF01920.15 CCF45306.1 - 2.3e-15 56.2 0.8 2.8e-15 55.9 0.5 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF4035 PF13227.1 CCF45306.1 - 0.076 12.4 0.5 5.1 6.5 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF4035) Rho_Binding PF08912.6 CCF45306.1 - 0.095 13.0 1.3 0.14 12.4 0.9 1.3 1 0 0 1 1 1 0 Rho Binding p450 PF00067.17 CCF45307.1 - 1.3e-72 244.7 0.0 1.5e-72 244.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Condensation PF00668.15 CCF45308.1 - 6.2e-17 61.3 0.0 5.8e-16 58.2 0.0 2.1 1 1 0 1 1 1 1 Condensation domain PP-binding PF00550.20 CCF45308.1 - 6.2e-09 36.0 0.1 1.6e-08 34.6 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site FAD_binding_3 PF01494.14 CCF45309.1 - 3.2e-86 289.5 0.0 3.9e-86 289.3 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF45309.1 - 2.8e-06 26.5 0.1 3.1e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.12 CCF45309.1 - 9.4e-06 24.8 0.0 0.0003 19.9 0.0 2.4 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.9 CCF45309.1 - 2e-05 24.6 0.1 0.00011 22.0 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF45309.1 - 3.6e-05 22.8 0.1 6e-05 22.0 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 CCF45309.1 - 7.7e-05 21.3 0.0 0.00012 20.6 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.7 CCF45309.1 - 0.00069 18.6 0.0 0.001 18.0 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.22 CCF45309.1 - 0.00098 19.4 0.0 0.0021 18.4 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CCF45309.1 - 0.0015 17.4 0.0 0.0024 16.8 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.1 CCF45309.1 - 0.0018 18.2 0.0 0.0041 17.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.2 CCF45309.1 - 0.0052 15.9 0.0 0.0096 15.0 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 CCF45309.1 - 0.025 14.6 0.1 0.069 13.1 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase XdhC_C PF13478.1 CCF45309.1 - 0.054 13.7 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain ThiF PF00899.16 CCF45309.1 - 0.055 13.2 0.1 0.13 12.0 0.1 1.7 1 0 0 1 1 1 0 ThiF family SE PF08491.5 CCF45309.1 - 0.082 11.7 0.0 1.7 7.4 0.0 2.2 2 0 0 2 2 2 0 Squalene epoxidase 3HCDH_N PF02737.13 CCF45309.1 - 0.083 12.5 0.1 0.3 10.7 0.0 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Trp_halogenase PF04820.9 CCF45309.1 - 0.088 11.4 0.0 0.14 10.7 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase NAD_binding_9 PF13454.1 CCF45309.1 - 0.13 12.0 0.0 0.27 10.9 0.0 1.7 1 0 0 1 1 1 0 FAD-NAD(P)-binding ApbA PF02558.11 CCF45309.1 - 0.14 11.5 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.9 CCF45309.1 - 0.16 11.3 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ChAPs PF09295.5 CCF45310.1 - 4.1e-135 450.5 0.0 5.1e-135 450.2 0.0 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_14 PF13428.1 CCF45310.1 - 2.2e-07 30.8 1.5 0.46 11.2 0.0 5.1 4 1 2 6 6 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 CCF45310.1 - 1.3e-05 24.7 1.1 0.33 10.6 0.1 3.9 4 0 0 4 4 4 2 TPR repeat TPR_19 PF14559.1 CCF45310.1 - 1.4e-05 25.2 0.2 0.12 12.7 0.0 4.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 CCF45310.1 - 8.3e-05 22.2 1.1 0.62 10.1 1.3 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 CCF45310.1 - 8.4e-05 22.0 1.2 0.34 10.8 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 CCF45310.1 - 0.00018 21.0 0.3 0.69 9.8 0.2 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat Apc3 PF12895.2 CCF45310.1 - 0.00083 19.4 1.0 2.3 8.3 0.0 3.4 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 CCF45310.1 - 0.0018 18.0 1.1 0.23 11.3 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 CCF45310.1 - 0.002 18.4 0.7 16 6.1 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 CCF45310.1 - 0.0048 17.5 2.0 21 5.9 0.9 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 CCF45310.1 - 0.016 15.0 0.7 3.5 7.6 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2007 PF09413.5 CCF45310.1 - 0.068 13.0 0.0 0.22 11.3 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF2007) TPR_1 PF00515.23 CCF45310.1 - 0.069 12.7 1.0 5.8 6.6 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat WSC PF01822.14 CCF45313.1 - 7.3e-50 166.8 45.7 1.1e-17 63.7 6.4 4.6 4 0 0 4 4 4 4 WSC domain PQQ_3 PF13570.1 CCF45313.1 - 3.3e-05 24.0 2.7 0.08 13.2 0.0 4.0 3 0 0 3 3 3 2 PQQ-like domain PQQ PF01011.16 CCF45313.1 - 1.5 8.5 7.6 3.9 7.1 0.2 4.3 4 0 0 4 4 4 0 PQQ enzyme repeat Beta-lactamase PF00144.19 CCF45314.1 - 6.9e-43 146.9 0.2 9.9e-43 146.3 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase F-box-like PF12937.2 CCF45315.1 - 0.012 15.2 0.3 0.028 14.1 0.2 1.7 1 0 0 1 1 1 0 F-box-like ABM PF03992.11 CCF45316.1 - 1.3e-07 31.5 2.1 0.0034 17.3 0.0 3.2 2 1 0 2 2 2 2 Antibiotic biosynthesis monooxygenase Dehydratase_hem PF13816.1 CCF45316.1 - 0.01 14.8 1.0 0.71 8.8 0.0 2.1 2 0 0 2 2 2 0 Haem-containing dehydratase HEAT_2 PF13646.1 CCF45317.1 - 4.6e-10 39.6 1.2 0.0005 20.2 0.0 4.1 4 1 0 4 4 4 2 HEAT repeats HEAT PF02985.17 CCF45317.1 - 3.3e-06 26.7 5.0 0.12 12.4 0.0 5.7 5 0 0 5 5 5 2 HEAT repeat Vac14_Fab1_bd PF12755.2 CCF45317.1 - 2.2e-05 24.7 0.1 0.0092 16.3 0.0 3.3 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.3 CCF45317.1 - 0.04 13.2 0.0 0.17 11.1 0.0 2.0 1 1 0 1 1 1 0 CLASP N terminal GATA PF00320.22 CCF45317.1 - 0.088 12.1 0.1 0.19 11.1 0.1 1.5 1 0 0 1 1 1 0 GATA zinc finger MutS_I PF01624.15 CCF45319.1 - 1.7e-28 98.9 0.0 2.5e-28 98.3 0.0 1.3 1 0 0 1 1 1 1 MutS domain I PBP1_TM PF14812.1 CCF45319.1 - 4.2 7.7 12.0 32 4.8 7.6 2.5 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Methyltransf_23 PF13489.1 CCF45320.1 - 1.1e-06 28.4 0.0 1.8e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 CCF45320.1 - 0.016 15.2 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_11 PF08241.7 CCF45320.1 - 0.017 15.6 0.0 0.033 14.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 CCF45320.1 - 0.022 14.3 0.0 0.043 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.14 CCF45320.1 - 0.033 13.7 0.0 0.058 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.2 CCF45320.1 - 0.083 13.4 0.1 0.15 12.6 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.11 CCF45321.1 - 4.7e-15 55.1 0.8 5.4e-15 54.9 0.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF45321.1 - 0.0012 17.5 0.1 0.0012 17.5 0.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Proteasome PF00227.21 CCF45323.1 - 3.2e-33 114.6 0.0 3.8e-33 114.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit WD40 PF00400.27 CCF45324.1 - 3.1e-31 106.1 3.0 1.8e-08 33.9 0.0 5.7 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.3 CCF45324.1 - 0.02 13.0 0.0 1.3 7.1 0.1 2.6 2 1 0 2 2 2 0 Nucleoporin Nup120/160 PQQ_3 PF13570.1 CCF45324.1 - 0.054 13.7 0.0 1.5 9.1 0.0 3.0 2 0 0 2 2 2 0 PQQ-like domain PBP1_TM PF14812.1 CCF45324.1 - 7.4 6.9 9.4 7.2 6.9 5.1 2.1 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Peptidase_C48 PF02902.14 CCF45325.1 - 5.2e-30 104.6 0.0 1.2e-29 103.5 0.0 1.6 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Pectate_lyase PF03211.8 CCF45327.1 - 7.5e-34 117.0 0.2 8.9e-34 116.7 0.1 1.0 1 0 0 1 1 1 1 Pectate lyase ketoacyl-synt PF00109.21 CCF45328.1 - 4.4e-79 265.5 0.1 5.6e-79 265.1 0.1 1.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 CCF45328.1 - 3.3e-36 123.7 0.1 9.9e-36 122.1 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 CCF45328.1 - 5.8e-05 22.1 0.1 0.0001 21.4 0.0 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 CCF45328.1 - 0.015 14.8 0.4 0.034 13.7 0.2 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DEAD PF00270.24 CCF45330.1 - 6.1e-19 68.1 0.0 1.1e-18 67.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF45330.1 - 1e-18 66.9 0.1 3.2e-17 62.1 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF45330.1 - 0.025 14.4 0.0 0.069 12.9 0.0 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit HTH_Tnp_Tc5 PF03221.11 CCF45332.1 - 1e-13 50.8 0.1 4.5e-13 48.8 0.0 2.1 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF45332.1 - 4.9e-12 45.2 0.1 8.7e-12 44.3 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_28 PF13518.1 CCF45332.1 - 0.00058 19.7 0.2 0.0025 17.7 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 CCF45332.1 - 0.00067 19.2 0.7 0.0021 17.6 0.0 2.3 3 0 0 3 3 3 1 Homeodomain-like domain CENP-B_N PF04218.8 CCF45332.1 - 0.013 14.9 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_29 PF13551.1 CCF45332.1 - 0.057 13.5 1.2 0.16 12.1 0.4 2.1 1 1 1 2 2 2 0 Winged helix-turn helix DDE_1 PF03184.14 CCF45332.1 - 0.078 12.0 0.0 0.14 11.2 0.0 1.5 1 0 0 1 1 1 0 DDE superfamily endonuclease HTH_8 PF02954.14 CCF45332.1 - 0.16 11.5 0.4 0.62 9.6 0.0 2.1 1 1 1 2 2 2 0 Bacterial regulatory protein, Fis family DUF1183 PF06682.7 CCF45333.1 - 0.12 11.9 0.7 0.13 11.8 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) DUF1932 PF09130.6 CCF45334.1 - 3.9e-18 64.9 1.0 6.1e-18 64.3 0.2 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1932) Sirohm_synth_C PF14823.1 CCF45334.1 - 0.1 11.9 0.0 0.22 10.8 0.0 1.6 1 0 0 1 1 1 0 Sirohaem biosynthesis protein C-terminal Maf_N PF08383.6 CCF45337.1 - 0.049 13.1 0.2 0.14 11.7 0.1 1.7 2 0 0 2 2 2 0 Maf N-terminal region DUF389 PF04087.9 CCF45338.1 - 0.062 13.2 0.3 0.074 13.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF389) KAP PF05804.7 CCF45339.1 - 7e-05 20.9 0.0 0.015 13.2 0.0 2.1 2 0 0 2 2 2 2 Kinesin-associated protein (KAP) HEAT_2 PF13646.1 CCF45339.1 - 0.00074 19.7 9.4 0.0027 17.9 0.2 3.7 1 1 2 3 3 3 2 HEAT repeats Arm PF00514.18 CCF45339.1 - 0.01 15.6 5.5 20 5.2 0.0 5.0 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat HEAT PF02985.17 CCF45339.1 - 0.076 13.1 0.1 0.076 13.1 0.1 3.4 5 0 0 5 5 5 0 HEAT repeat CAF-1_p150 PF11600.3 CCF45340.1 - 0.0029 17.0 39.2 0.0047 16.3 27.2 1.2 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal SAPS PF04499.10 CCF45340.1 - 0.0036 16.0 5.7 0.0049 15.5 3.9 1.4 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein Borrelia_P83 PF05262.6 CCF45340.1 - 0.01 14.1 18.9 0.013 13.7 13.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF4407 PF14362.1 CCF45340.1 - 0.025 13.5 22.6 0.036 13.0 15.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MIP-T3 PF10243.4 CCF45340.1 - 0.25 9.7 39.0 0.34 9.3 27.0 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 SprA-related PF12118.3 CCF45340.1 - 0.35 10.1 22.0 0.48 9.7 15.2 1.2 1 0 0 1 1 1 0 SprA-related family LMBR1 PF04791.11 CCF45340.1 - 0.97 7.9 2.6 1.1 7.7 1.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein SOBP PF15279.1 CCF45340.1 - 1.2 9.4 6.1 2.1 8.6 4.2 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein AAA PF00004.24 CCF45341.1 - 4.5e-09 36.5 0.1 9.4e-09 35.5 0.0 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF500 PF04366.7 CCF45342.1 - 2.2e-10 40.0 0.0 2.9e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF500) Aminotran_3 PF00202.16 CCF45343.1 - 5.3e-44 150.4 0.0 3.8e-24 85.1 0.0 2.3 2 0 0 2 2 2 2 Aminotransferase class-III AAA_26 PF13500.1 CCF45343.1 - 2e-17 63.4 0.0 3.5e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain Mito_carr PF00153.22 CCF45344.1 - 3.5e-37 126.0 0.1 1.5e-16 59.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4451 PF14616.1 CCF45346.1 - 5.5e-35 119.8 0.4 5.5e-35 119.8 0.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4451) Suf PF05843.9 CCF45346.1 - 7.4 6.2 12.2 17 5.0 8.4 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) WSC PF01822.14 CCF45347.1 - 1.4e-42 143.4 50.4 3.1e-18 65.4 7.3 4.1 4 0 0 4 4 4 3 WSC domain Methyltransf_2 PF00891.13 CCF45348.1 - 2.8e-15 56.2 0.0 3.4e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Abhydrolase_4 PF08386.5 CCF45349.1 - 1.5e-06 28.0 0.2 2.3e-06 27.4 0.1 1.3 1 0 0 1 1 1 1 TAP-like protein BAH PF01426.13 CCF45351.1 - 5.7e-05 22.8 0.0 0.00024 20.8 0.0 2.0 1 1 1 2 2 2 1 BAH domain PHD PF00628.24 CCF45351.1 - 0.41 10.3 9.1 0.061 13.0 3.4 1.8 2 0 0 2 2 2 0 PHD-finger Cauli_DNA-bind PF03310.8 CCF45352.1 - 0.07 12.9 0.2 0.24 11.2 0.1 2.0 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein PBP_sp32 PF07222.7 CCF45355.1 - 1.2 8.3 7.5 1.4 8.0 5.2 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 AMP-binding PF00501.23 CCF45356.1 - 7.2e-23 80.6 0.0 2.4e-22 78.9 0.0 1.7 2 0 0 2 2 2 1 AMP-binding enzyme PP-binding PF00550.20 CCF45356.1 - 4e-06 27.0 0.0 7.9e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site NAD_binding_4 PF07993.7 CCF45356.1 - 0.00069 18.6 0.0 0.0015 17.4 0.0 1.6 1 0 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.10 CCF45356.1 - 0.18 10.6 0.0 0.47 9.2 0.0 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein p450 PF00067.17 CCF45358.1 - 4.7e-36 124.3 0.0 5.9e-36 123.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Adaptin_N PF01602.15 CCF45360.1 - 1.6e-107 360.0 0.0 1.9e-107 359.7 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 CCF45360.1 - 6.2e-13 48.8 4.3 1.7e-05 25.0 0.0 5.0 4 1 0 4 4 4 3 HEAT repeats HEAT PF02985.17 CCF45360.1 - 3.9e-10 38.9 0.2 0.026 14.5 0.0 6.2 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.1 CCF45360.1 - 4.2e-06 27.0 5.3 0.0042 17.5 0.0 5.3 5 0 0 5 5 5 1 HEAT-like repeat Cohesin_HEAT PF12765.2 CCF45360.1 - 0.0015 18.4 1.0 0.14 12.1 0.0 3.3 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion Cnd1 PF12717.2 CCF45360.1 - 0.0099 15.7 0.0 0.17 11.7 0.0 2.7 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 VHS PF00790.14 CCF45360.1 - 0.073 12.7 0.3 24 4.5 0.0 3.5 4 0 0 4 4 4 0 VHS domain Trehalase PF01204.13 CCF45361.1 - 6.3e-195 648.6 0.0 7.6e-195 648.3 0.0 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.6 CCF45361.1 - 2.5e-16 58.6 0.1 4.3e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain Mito_carr PF00153.22 CCF45362.1 - 1.5e-28 98.3 4.9 1.4e-12 47.1 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein E1-E2_ATPase PF00122.15 CCF45366.1 - 5.1e-42 143.4 0.5 6.8e-42 143.0 0.4 1.2 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_N PF00690.21 CCF45366.1 - 4.6e-09 35.6 0.1 7.9e-09 34.8 0.0 1.4 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus MIP-T3 PF10243.4 CCF45367.1 - 7.9e-05 21.3 20.5 7.9e-05 21.3 14.2 1.6 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 CAF-1_p150 PF11600.3 CCF45367.1 - 0.0051 16.2 30.8 0.0051 16.2 21.4 2.0 2 0 0 2 2 2 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Spore_coat_CotO PF14153.1 CCF45367.1 - 0.73 9.2 10.8 1.3 8.4 7.5 1.4 1 0 0 1 1 1 0 Spore coat protein CotO eIF-3_zeta PF05091.7 CCF45367.1 - 1.1 7.7 11.1 1.8 7.1 7.7 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) USP7_ICP0_bdg PF12436.3 CCF45370.1 - 3.5e-51 173.8 0.6 4.9e-50 170.0 0.0 2.5 1 1 1 2 2 2 2 ICP0-binding domain of Ubiquitin-specific protease 7 UCH PF00443.24 CCF45370.1 - 2.9e-32 111.8 1.1 4.5e-32 111.2 0.8 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CCF45370.1 - 2.8e-09 36.8 0.0 5.6e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ribosomal_L29e PF01779.12 CCF45371.1 - 4e-23 80.9 9.2 6.1e-23 80.3 6.4 1.3 1 0 0 1 1 1 1 Ribosomal L29e protein family p450 PF00067.17 CCF45372.1 - 3.5e-33 114.8 0.0 6.3e-33 113.9 0.0 1.3 2 0 0 2 2 2 1 Cytochrome P450 DUF3602 PF12223.3 CCF45373.1 - 4.1e-13 49.5 4.8 6.4e-08 32.8 0.4 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF3602) DUF791 PF05631.9 CCF45374.1 - 9.5e-20 70.5 1.1 1e-19 70.5 0.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF791) Big_1 PF02369.11 CCF45376.1 - 0.1 12.4 0.0 0.29 11.0 0.0 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) Bromodomain PF00439.20 CCF45380.1 - 1.4e-20 73.0 0.2 1.4e-20 73.0 0.1 2.3 3 0 0 3 3 3 1 Bromodomain DUF4635 PF15466.1 CCF45380.1 - 0.027 13.7 0.4 0.068 12.4 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) Prefoldin PF02996.12 CCF45380.1 - 0.21 11.2 5.0 1.2 8.7 0.1 3.1 3 0 0 3 3 3 0 Prefoldin subunit PS-DH PF14765.1 CCF45382.1 - 1.4e-53 182.0 3.0 1.9e-53 181.5 2.1 1.1 1 0 0 1 1 1 1 Polyketide synthase dehydratase RNase_P_pop3 PF08228.6 CCF45383.1 - 2.7e-08 33.7 0.0 7.2e-06 25.9 0.0 2.2 2 0 0 2 2 2 2 RNase P subunit Pop3 zf-C5HC2 PF02928.11 CCF45384.1 - 0.1 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 C5HC2 zinc finger DUF2668 PF10873.3 CCF45384.1 - 0.74 9.9 2.8 1.7 8.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2668) DUF917 PF06032.7 CCF45385.1 - 4.3e-78 262.3 0.0 4.8e-78 262.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Thioredoxin PF00085.15 CCF45387.1 - 2.9e-63 210.0 6.4 7.2e-32 109.1 0.1 4.1 4 1 0 4 4 4 3 Thioredoxin Thioredoxin_6 PF13848.1 CCF45387.1 - 7.3e-54 182.3 0.7 3.7e-39 134.4 0.2 3.6 2 2 2 4 4 4 3 Thioredoxin-like domain Thioredoxin_8 PF13905.1 CCF45387.1 - 1.2e-12 47.8 0.1 4.4e-05 23.5 0.0 4.0 2 1 0 3 3 3 2 Thioredoxin-like Thioredoxin_7 PF13899.1 CCF45387.1 - 3.5e-12 46.1 0.8 2.2e-05 24.3 0.0 3.3 4 0 0 4 4 4 2 Thioredoxin-like Thioredoxin_2 PF13098.1 CCF45387.1 - 4.9e-11 42.8 4.5 0.00012 22.2 0.1 4.4 3 2 0 3 3 3 2 Thioredoxin-like domain Calsequestrin PF01216.12 CCF45387.1 - 3.9e-09 35.7 3.3 4.1e-09 35.7 0.8 2.1 2 1 0 2 2 2 1 Calsequestrin AhpC-TSA PF00578.16 CCF45387.1 - 2e-08 33.9 1.8 0.0015 18.1 0.1 3.3 3 0 0 3 3 3 2 AhpC/TSA family Redoxin PF08534.5 CCF45387.1 - 4.8e-07 29.4 7.2 0.00038 20.0 0.0 3.7 4 1 0 4 4 4 2 Redoxin Thioredoxin_4 PF13462.1 CCF45387.1 - 0.00094 19.2 3.7 1.2 9.1 0.1 3.9 3 1 0 3 3 3 2 Thioredoxin Thioredoxin_3 PF13192.1 CCF45387.1 - 0.0049 16.6 0.2 0.025 14.3 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin domain DUF3186 PF11382.3 CCF45387.1 - 0.011 14.8 0.2 0.024 13.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3186) DSBA PF01323.15 CCF45387.1 - 0.062 12.8 0.0 20 4.6 0.0 3.3 2 1 1 3 3 3 0 DSBA-like thioredoxin domain NMD3 PF04981.8 CCF45387.1 - 0.47 9.5 2.2 3.9 6.5 0.0 2.8 3 0 0 3 3 3 0 NMD3 family Polysacc_deac_1 PF01522.16 CCF45388.1 - 7.8e-23 80.4 0.3 1.7e-22 79.3 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.14 CCF45388.1 - 7.3e-07 29.0 43.5 2.4e-05 24.1 16.9 3.8 3 1 1 4 4 4 2 Chitin recognition protein CompInhib_SCIN PF11546.3 CCF45388.1 - 0.11 12.4 0.1 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Staphylococcal complement inhibitor SCIN MFS_1 PF07690.11 CCF45392.1 - 3e-20 72.2 15.9 7.7e-20 70.8 11.0 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Tmemb_18A PF09771.4 CCF45392.1 - 0.092 12.7 2.8 6.8 6.6 0.0 2.7 3 0 0 3 3 3 0 Transmembrane protein 188 UNC-93 PF05978.11 CCF45392.1 - 3.1 7.2 12.1 1.9 7.9 6.7 1.9 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 DUF2236 PF09995.4 CCF45393.1 - 7.9e-07 28.6 0.4 1.2e-06 27.9 0.2 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) RRM_1 PF00076.17 CCF45394.1 - 0.00013 21.5 0.1 0.00026 20.5 0.0 1.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF45394.1 - 0.071 13.1 0.0 0.16 11.9 0.0 1.6 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) p450 PF00067.17 CCF45398.1 - 7.5e-51 173.0 0.0 2.1e-50 171.5 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 Prenyltrans_2 PF13249.1 CCF45399.1 - 0.00014 22.2 0.1 0.00018 21.8 0.1 1.2 1 0 0 1 1 1 1 Prenyltransferase-like Prenyltrans_1 PF13243.1 CCF45399.1 - 0.00022 21.2 0.6 0.00081 19.3 0.1 1.7 1 1 0 1 1 1 1 Prenyltransferase-like Prenyltrans PF00432.16 CCF45399.1 - 0.00073 19.0 0.2 0.14 11.7 0.0 2.3 2 0 0 2 2 2 2 Prenyltransferase and squalene oxidase repeat Cytochrom_C550 PF14495.1 CCF45399.1 - 0.075 12.4 0.0 0.087 12.2 0.0 1.1 1 0 0 1 1 1 0 Cytochrome c-550 domain MLANA PF14991.1 CCF45402.1 - 0.00068 19.6 0.0 0.00097 19.1 0.0 1.2 1 0 0 1 1 1 1 Protein melan-A Shisa PF13908.1 CCF45402.1 - 0.0079 16.3 0.0 0.009 16.2 0.0 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Ctr PF04145.10 CCF45402.1 - 0.033 14.2 0.0 0.042 13.8 0.0 1.2 1 0 0 1 1 1 0 Ctr copper transporter family Herpes_gE PF02480.11 CCF45402.1 - 0.084 11.1 0.0 0.093 10.9 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E SKG6 PF08693.5 CCF45402.1 - 0.09 12.1 0.2 0.09 12.1 0.1 1.8 2 0 0 2 2 2 0 Transmembrane alpha-helix domain DUF2360 PF10152.4 CCF45402.1 - 0.14 12.4 0.9 0.13 12.5 0.6 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Herpes_capsid PF06112.6 CCF45402.1 - 0.57 10.2 6.6 0.84 9.6 4.6 1.3 1 1 0 1 1 1 0 Gammaherpesvirus capsid protein FAP PF07174.6 CCF45402.1 - 2.5 7.3 18.7 3.1 7.0 13.0 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Carb_kinase PF01256.12 CCF45403.1 - 1.3e-55 188.2 0.1 1.8e-55 187.9 0.0 1.2 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.10 CCF45403.1 - 0.00016 20.9 0.5 0.00024 20.3 0.0 1.5 2 0 0 2 2 2 1 Hydroxyethylthiazole kinase family MPC PF03650.8 CCF45404.1 - 6.8e-36 122.8 0.0 8.3e-36 122.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) Fasciclin PF02469.17 CCF45407.1 - 1.6e-38 131.5 0.0 5e-20 71.8 0.0 2.2 2 0 0 2 2 2 2 Fasciclin domain CN_hydrolase PF00795.17 CCF45412.1 - 2.8e-31 108.3 0.0 3.3e-31 108.0 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Sugar_tr PF00083.19 CCF45413.1 - 6.2e-87 292.0 24.5 7e-87 291.8 17.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF45413.1 - 5.4e-20 71.4 26.4 9.1e-13 47.6 8.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CCF45413.1 - 0.00093 17.6 34.8 0.0054 15.1 1.7 4.0 2 2 2 4 4 4 3 MFS/sugar transport protein FGGY_C PF02782.11 CCF45414.1 - 1.1e-71 240.5 0.8 2.1e-71 239.6 0.6 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 CCF45414.1 - 2.2e-61 207.3 0.0 2.9e-61 206.9 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain DUF1612 PF07756.7 CCF45414.1 - 0.048 13.7 0.0 0.098 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1612) NTP_transferase PF00483.18 CCF45415.1 - 3.7e-49 167.2 0.0 8.9e-49 166.0 0.0 1.6 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.19 CCF45415.1 - 2.6e-16 58.3 12.7 1.4e-09 37.0 1.1 3.9 2 2 2 4 4 4 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 CCF45415.1 - 1.5e-11 44.5 0.0 2.3e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.1 CCF45415.1 - 4.6e-08 32.4 3.8 1.9e-06 27.2 0.7 3.0 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase IspD PF01128.14 CCF45415.1 - 0.0061 16.0 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CTP_transf_3 PF02348.14 CCF45415.1 - 0.0065 16.1 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase DUF2207 PF09972.4 CCF45416.1 - 0.00028 19.5 0.6 0.00029 19.5 0.4 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Anoctamin PF04547.7 CCF45416.1 - 0.0052 15.4 0.1 0.0062 15.2 0.1 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel VIT1 PF01988.14 CCF45416.1 - 0.021 14.3 0.2 0.025 14.0 0.1 1.1 1 0 0 1 1 1 0 VIT family DUF4191 PF13829.1 CCF45416.1 - 0.032 13.3 2.2 0.038 13.0 1.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Pex24p PF06398.6 CCF45416.1 - 0.47 9.1 8.9 0.66 8.7 6.1 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Tic20 PF09685.5 CCF45416.1 - 0.55 10.2 17.9 0.75 9.8 12.4 1.2 1 0 0 1 1 1 0 Tic20-like protein O-antigen_lig PF13425.1 CCF45416.1 - 1.8 8.5 12.2 2.8 7.9 8.4 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein VirB3 PF05101.8 CCF45416.1 - 5 7.1 8.2 8.7 6.4 5.7 1.4 1 0 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein Phlebovirus_G2 PF07245.6 CCF45416.1 - 6.1 4.9 6.8 7.4 4.7 4.7 1.2 1 0 0 1 1 1 0 Phlebovirus glycoprotein G2 DUF3796 PF12676.2 CCF45416.1 - 7.1 6.8 16.8 1 9.5 9.1 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3796) p450 PF00067.17 CCF45417.1 - 2.5e-33 115.3 0.0 2.9e-33 115.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DAGAT PF03982.8 CCF45418.1 - 0.00043 19.0 0.3 0.00061 18.5 0.2 1.2 1 0 0 1 1 1 1 Diacylglycerol acyltransferase IPK PF03770.11 CCF45419.1 - 0.048 13.2 1.2 0.051 13.2 0.8 1.1 1 0 0 1 1 1 0 Inositol polyphosphate kinase PSD5 PF07637.6 CCF45419.1 - 0.054 13.5 0.9 0.088 12.8 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1595) Glyco_tran_28_C PF04101.11 CCF45419.1 - 0.11 12.1 0.7 0.14 11.8 0.5 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain Dehydrin PF00257.14 CCF45419.1 - 0.18 12.1 2.6 0.25 11.6 1.8 1.2 1 0 0 1 1 1 0 Dehydrin RP-C_C PF11800.3 CCF45419.1 - 0.19 11.4 6.0 0.24 11.0 4.2 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region bZIP_1 PF00170.16 CCF45419.1 - 0.22 11.4 12.5 0.67 9.9 8.7 1.7 1 1 0 1 1 1 0 bZIP transcription factor Selenoprotein_S PF06936.6 CCF45419.1 - 0.47 9.9 5.2 0.52 9.8 3.6 1.1 1 0 0 1 1 1 0 Selenoprotein S (SelS) Herpes_UL25 PF01499.11 CCF45419.1 - 0.91 7.7 5.7 0.92 7.7 4.0 1.0 1 0 0 1 1 1 0 Herpesvirus UL25 family IFT20 PF14931.1 CCF45419.1 - 3.4 7.5 9.0 5 7.0 6.3 1.2 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 Sugar_tr PF00083.19 CCF45420.1 - 9.8e-98 327.6 30.1 1.2e-97 327.4 20.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF45420.1 - 4.6e-21 74.9 32.1 4.6e-21 74.9 22.2 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF983 PF06170.7 CCF45420.1 - 0.17 11.9 2.8 0.29 11.2 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF983) Colicin PF01024.14 CCF45420.1 - 0.21 11.1 3.3 6.5 6.2 0.8 2.4 2 0 0 2 2 2 0 Colicin pore forming domain Aldolase_II PF00596.16 CCF45421.1 - 4.7e-48 163.2 0.0 5.8e-48 162.9 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Glyco_hydro_88 PF07470.8 CCF45422.1 - 2e-41 142.1 0.2 2.2e-41 142.0 0.1 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Peptidase_C32 PF05411.7 CCF45422.1 - 0.15 11.7 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Equine arteritis virus putative proteinase Tannase PF07519.6 CCF45423.1 - 3.9e-76 256.6 0.5 4.9e-76 256.3 0.3 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase HSP90 PF00183.13 CCF45424.1 - 0.48 8.7 5.8 0.57 8.5 4.0 1.0 1 0 0 1 1 1 0 Hsp90 protein Med19 PF10278.4 CCF45424.1 - 0.58 9.8 5.8 0.67 9.6 4.0 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Sad1_UNC PF07738.8 CCF45425.1 - 4.4e-09 36.2 0.0 9.4e-08 31.9 0.0 2.3 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal FAM75 PF14650.1 CCF45425.1 - 0.13 11.6 0.8 0.16 11.3 0.6 1.1 1 0 0 1 1 1 0 FAM75 family Complex1_LYR_1 PF13232.1 CCF45425.1 - 0.66 10.2 2.6 8.2 6.7 1.8 2.5 1 1 0 1 1 1 0 Complex1_LYR-like Dynamin_N PF00350.18 CCF45427.1 - 4.1e-31 108.0 0.0 7.1e-31 107.2 0.0 1.4 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 CCF45427.1 - 7.8e-13 47.8 0.3 1.7e-12 46.7 0.2 1.5 1 0 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.18 CCF45427.1 - 0.0027 17.6 0.0 0.017 15.1 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CCF45427.1 - 0.062 13.7 0.0 0.2 12.1 0.0 1.9 2 0 0 2 2 2 0 Miro-like protein DUF507 PF04368.8 CCF45427.1 - 0.1 12.2 2.2 0.39 10.3 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF507) DUF1736 PF08409.6 CCF45429.1 - 1.5 8.4 5.5 7.8 6.1 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1736) DDE_1 PF03184.14 CCF45430.1 - 0.00037 19.6 0.0 0.00052 19.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 CCF45430.1 - 0.23 11.2 1.4 0.32 10.8 0.2 1.8 1 1 1 2 2 2 0 Tc5 transposase DNA-binding domain Synaptobrevin PF00957.16 CCF45432.1 - 0.00079 18.9 0.6 0.0071 15.9 0.2 2.0 1 1 1 2 2 2 1 Synaptobrevin LPP PF04728.8 CCF45432.1 - 0.079 12.7 0.3 0.13 12.0 0.2 1.4 1 0 0 1 1 1 0 Lipoprotein leucine-zipper SNARE PF05739.14 CCF45432.1 - 0.11 12.1 0.0 0.52 10.0 0.0 1.9 1 1 0 1 1 1 0 SNARE domain Amino_oxidase PF01593.19 CCF45435.1 - 3.1e-11 43.0 0.3 0.00056 19.0 0.0 3.1 3 0 0 3 3 3 3 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 CCF45435.1 - 5.8e-10 39.0 0.1 1.3e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF45435.1 - 8.3e-08 32.5 0.2 0.0034 17.4 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF45435.1 - 1.3e-06 27.5 0.3 0.0027 16.6 0.0 3.0 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF45435.1 - 1.3e-05 25.2 0.0 0.0024 17.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF45435.1 - 4.9e-05 23.1 0.1 0.017 14.8 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding HI0933_like PF03486.9 CCF45435.1 - 0.0007 18.1 0.1 0.76 8.1 0.0 2.5 3 0 0 3 3 3 2 HI0933-like protein GIDA PF01134.17 CCF45435.1 - 0.11 11.3 0.4 0.19 10.5 0.1 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A Aminotran_4 PF01063.14 CCF45436.1 - 2.2e-12 46.9 0.0 2.7e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV Amidoligase_2 PF12224.3 CCF45437.1 - 0.045 13.3 0.0 0.049 13.2 0.0 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme CBM_1 PF00734.13 CCF45438.1 - 2.2e-09 36.8 12.3 4.9e-09 35.6 8.5 1.6 1 0 0 1 1 1 1 Fungal cellulose binding domain WD40 PF00400.27 CCF45440.1 - 1.7e-27 94.2 5.1 3.4e-09 36.2 0.1 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 CCF45440.1 - 5.1e-18 64.7 0.1 1.4e-17 63.3 0.0 1.8 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex DUF1627 PF07789.7 CCF45441.1 - 0.049 13.1 0.8 0.087 12.3 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1627) Borrelia_P83 PF05262.6 CCF45441.1 - 0.18 10.0 10.0 0.18 10.0 6.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein NARP1 PF12569.3 CCF45441.1 - 0.82 8.3 9.5 0.89 8.2 6.6 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 RR_TM4-6 PF06459.7 CCF45441.1 - 2.2 8.1 10.2 3.2 7.5 7.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4551 PF15087.1 CCF45441.1 - 3 6.0 10.6 3.5 5.8 7.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Gastrin PF00918.12 CCF45441.1 - 6 7.7 8.9 1.7 9.4 3.5 1.8 2 0 0 2 2 2 0 Gastrin/cholecystokinin family zf-RING_5 PF14634.1 CCF45442.1 - 6.6e-05 22.5 2.2 0.00015 21.3 1.5 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CCF45442.1 - 0.013 15.5 0.8 0.013 15.5 0.5 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 CCF45442.1 - 0.026 14.2 0.1 0.079 12.6 0.1 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.20 CCF45442.1 - 0.066 12.8 0.6 0.15 11.7 0.4 1.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF45442.1 - 0.076 12.8 2.2 0.1 12.4 0.3 1.9 2 0 0 2 2 2 0 Ring finger domain Prok-RING_4 PF14447.1 CCF45442.1 - 0.36 10.4 3.1 0.26 10.8 0.3 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 WD40 PF00400.27 CCF45443.1 - 0.00012 21.7 0.0 0.01 15.7 0.0 2.7 3 0 0 3 3 3 1 WD domain, G-beta repeat Lactonase PF10282.4 CCF45443.1 - 0.0073 15.4 0.0 0.0088 15.1 0.0 1.2 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Palm_thioest PF02089.10 CCF45443.1 - 0.018 14.0 0.0 0.02 13.8 0.0 1.0 1 0 0 1 1 1 0 Palmitoyl protein thioesterase MFS_1 PF07690.11 CCF45444.1 - 1.3e-36 126.1 26.3 1.3e-36 126.1 18.2 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF2207 PF09972.4 CCF45444.1 - 9.2 4.7 7.2 1.9 6.9 0.6 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) MFS_2 PF13347.1 CCF45445.1 - 6.9e-14 51.0 21.4 2.1e-13 49.4 14.8 1.7 1 1 0 1 1 1 1 MFS/sugar transport protein RESP18 PF14948.1 CCF45447.1 - 0.036 14.0 0.6 6.5 6.8 0.1 2.8 2 1 0 2 2 2 0 RESP18 domain APG6 PF04111.7 CCF45447.1 - 0.18 10.8 2.3 0.093 11.7 0.2 1.5 2 0 0 2 2 2 0 Autophagy protein Apg6 SbcD_C PF12320.3 CCF45447.1 - 0.73 9.8 6.8 0.51 10.4 1.4 2.2 2 0 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain IncA PF04156.9 CCF45447.1 - 2.2 7.8 7.7 0.99 8.9 1.6 2.0 2 0 0 2 2 2 0 IncA protein Sec10 PF07393.6 CCF45448.1 - 2.3e-113 379.7 3.0 2.6e-113 379.6 2.1 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 KfrA_N PF11740.3 CCF45448.1 - 0.23 11.9 2.6 0.9 9.9 0.1 2.8 2 1 1 3 3 3 0 Plasmid replication region DNA-binding N-term Adaptin_N PF01602.15 CCF45450.1 - 1.8e-31 109.0 0.0 2.2e-31 108.8 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 CCF45450.1 - 0.0054 16.9 0.3 0.42 10.9 0.2 2.8 1 1 0 1 1 1 1 HEAT repeats TFIIA PF03153.8 CCF45450.1 - 1.1 9.1 23.0 1.4 8.7 16.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ECH PF00378.15 CCF45451.1 - 2.2e-10 40.1 0.0 2.5e-10 39.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Mo-co_dimer PF03404.11 CCF45452.1 - 3e-23 81.8 1.2 4e-23 81.4 0.8 1.2 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain HTH_24 PF13412.1 CCF45452.1 - 0.13 11.6 0.1 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Hemerythrin PF01814.18 CCF45453.1 - 1.7e-13 50.9 1.7 2.4e-13 50.4 1.2 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Peptidase_M28 PF04389.12 CCF45454.1 - 1.2e-38 132.5 0.0 1.7e-38 132.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 BTB PF00651.26 CCF45455.1 - 1.1e-07 31.7 0.0 6.7e-07 29.2 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain Ank_3 PF13606.1 CCF45455.1 - 0.046 13.9 0.1 0.37 11.1 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeat 3HCDH_N PF02737.13 CCF45456.1 - 1.8e-22 79.8 0.0 2.3e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.17 CCF45456.1 - 3.4e-15 56.1 0.0 5.2e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain DUF3432 PF11914.3 CCF45460.1 - 1.6 8.7 11.2 1.1 9.3 6.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) Glyco_hydro_61 PF03443.9 CCF45462.1 - 3.2e-48 164.4 0.0 3.7e-48 164.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 A2M_N PF01835.14 CCF45462.1 - 0.0075 16.5 0.0 0.014 15.6 0.0 1.4 1 0 0 1 1 1 1 MG2 domain Microtub_assoc PF07989.6 CCF45463.1 - 0.0036 17.0 1.2 0.0036 17.0 0.8 2.7 2 1 0 3 3 3 1 Microtubule associated APG6 PF04111.7 CCF45463.1 - 4.3 6.2 10.2 0.41 9.6 3.8 1.6 2 0 0 2 2 2 0 Autophagy protein Apg6 PilM PF07419.7 CCF45464.1 - 0.086 12.3 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 PilM HTH_29 PF13551.1 CCF45466.1 - 0.019 15.0 0.1 0.054 13.6 0.1 1.8 1 0 0 1 1 1 0 Winged helix-turn helix PqqD PF05402.7 CCF45466.1 - 0.12 12.3 0.0 5.8 7.0 0.0 2.7 2 0 0 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) DUF4463 PF14703.1 CCF45466.1 - 0.13 12.7 6.5 2.9 8.4 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4463) SF3b10 PF07189.6 CCF45467.1 - 5.2e-35 119.1 0.0 6e-35 118.9 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) MAGE PF01454.14 CCF45468.1 - 3.7e-33 114.5 0.0 5.4e-33 113.9 0.0 1.2 1 0 0 1 1 1 1 MAGE family Tom22 PF04281.8 CCF45468.1 - 5.2 6.6 6.9 13 5.2 4.8 1.7 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 DUF883 PF05957.8 CCF45468.1 - 7.4 7.0 7.6 0.28 11.6 0.5 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) SLS PF14611.1 CCF45469.1 - 4.3e-32 111.2 0.6 6.4e-32 110.6 0.4 1.3 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator EBP50_C-term PF09007.6 CCF45469.1 - 0.14 12.0 0.4 0.65 9.8 0.3 2.2 1 0 0 1 1 1 0 EBP50, C-terminal Glyco_hydro_11 PF00457.12 CCF45470.1 - 6.2e-45 152.7 2.6 6.9e-45 152.6 1.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 NAD_binding_10 PF13460.1 CCF45471.1 - 3.7e-13 49.8 0.1 5.1e-13 49.4 0.1 1.3 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF45471.1 - 6.9e-11 41.8 0.0 1.1e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Saccharop_dh PF03435.13 CCF45471.1 - 0.0001 21.4 0.1 0.00013 21.0 0.0 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase Epimerase PF01370.16 CCF45471.1 - 0.01 15.2 0.1 0.016 14.6 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Glyco_trans_4_4 PF13579.1 CCF45471.1 - 0.079 13.1 1.4 0.28 11.2 0.6 2.0 2 1 0 2 2 2 0 Glycosyl transferase 4-like domain DapB_N PF01113.15 CCF45471.1 - 0.11 12.4 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.20 CCF45471.1 - 0.12 12.2 1.2 0.24 11.3 0.8 1.5 1 1 0 1 1 1 0 short chain dehydrogenase DUF3999 PF13163.1 CCF45472.1 - 0.073 12.0 0.1 0.081 11.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3999) FYVE PF01363.16 CCF45473.1 - 5.1e-14 51.9 10.7 9.4e-14 51.0 7.4 1.5 1 0 0 1 1 1 1 FYVE zinc finger zf-AN1 PF01428.11 CCF45473.1 - 0.023 14.5 9.2 0.023 14.5 6.4 1.7 1 1 0 1 1 1 0 AN1-like Zinc finger STAS PF01740.16 CCF45474.1 - 1.8e-06 27.3 0.0 2.8e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 STAS domain SMAP PF15477.1 CCF45479.1 - 7.7e-17 61.3 7.6 7.7e-17 61.3 5.2 5.6 3 2 1 4 4 4 1 Small acidic protein family Formyl_trans_N PF00551.14 CCF45483.1 - 8.4e-21 74.3 0.0 1.2e-20 73.8 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase NICE-3 PF07406.6 CCF45484.1 - 0.038 13.4 0.6 0.063 12.7 0.4 1.3 1 0 0 1 1 1 0 NICE-3 protein PSD4 PF07631.6 CCF45484.1 - 0.073 13.4 1.2 0.14 12.5 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1592) CX PF01705.14 CCF45484.1 - 0.41 10.6 2.4 35 4.4 0.0 3.1 3 0 0 3 3 3 0 CX module DUF1366 PF07104.6 CCF45484.1 - 3.1 7.4 11.4 0.45 10.1 2.2 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1366) Synaptobrevin PF00957.16 CCF45484.1 - 7.3 6.2 8.6 1.7 8.2 2.1 2.6 1 1 1 2 2 2 0 Synaptobrevin ABC_membrane_2 PF06472.10 CCF45485.1 - 2.6e-109 364.7 0.8 2.6e-109 364.7 0.6 1.5 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 CCF45485.1 - 2.1e-17 63.7 0.0 5.2e-17 62.4 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 CCF45485.1 - 0.00045 20.2 0.0 0.0013 18.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF45485.1 - 0.013 15.5 0.3 0.041 13.8 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.1 CCF45485.1 - 0.035 13.6 0.0 0.078 12.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.14 CCF45485.1 - 0.05 12.8 0.2 0.22 10.7 0.0 2.1 2 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 CCF45485.1 - 0.06 13.6 0.1 0.25 11.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 CCF45485.1 - 0.077 12.1 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 zf-CSL PF05207.8 CCF45486.1 - 5.5e-26 89.8 1.3 7.2e-26 89.4 0.9 1.2 1 0 0 1 1 1 1 CSL zinc finger Zn-ribbon_8 PF09723.5 CCF45486.1 - 0.0077 16.1 0.5 0.013 15.4 0.3 1.5 1 0 0 1 1 1 1 Zinc ribbon domain Terminase_GpA PF05876.7 CCF45486.1 - 0.051 11.9 0.1 0.058 11.7 0.1 1.1 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) TF_Zn_Ribbon PF08271.7 CCF45486.1 - 0.094 12.0 0.5 0.2 10.9 0.3 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding Prok-RING_1 PF14446.1 CCF45486.1 - 0.68 9.7 3.4 2.4 7.9 2.4 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 tRNA-synt_1 PF00133.17 CCF45487.1 - 3.2e-37 127.8 0.4 4e-27 94.4 0.0 3.7 2 2 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 CCF45487.1 - 2.6e-16 59.2 0.0 1.4e-09 37.1 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 CCF45487.1 - 2.3e-11 43.6 0.9 5.8e-11 42.3 0.6 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 CCF45487.1 - 8.1e-08 31.7 0.0 2e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Clat_adaptor_s PF01217.15 CCF45489.1 - 9e-43 145.4 0.0 1.7e-42 144.4 0.0 1.4 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Frataxin_Cyay PF01491.11 CCF45490.1 - 5.4e-34 116.2 0.0 7.1e-34 115.8 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain AJAP1_PANP_C PF15298.1 CCF45491.1 - 0.00049 20.0 0.1 0.00067 19.5 0.0 1.2 1 0 0 1 1 1 1 AJAP1/PANP C-terminus DUF4381 PF14316.1 CCF45491.1 - 0.0085 16.2 0.0 0.012 15.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) Mid2 PF04478.7 CCF45491.1 - 0.14 11.6 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Response_reg PF00072.19 CCF45492.1 - 2.5e-19 69.3 0.0 3.2e-19 68.9 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain Aldedh PF00171.17 CCF45493.1 - 3e-05 22.5 0.1 4e-05 22.1 0.1 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Peptidase_S8 PF00082.17 CCF45495.1 - 1.9e-17 63.3 0.3 1.9e-16 60.0 0.1 2.0 2 0 0 2 2 2 1 Subtilase family DUF1034 PF06280.7 CCF45495.1 - 1.8e-05 25.1 0.0 2.9e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Fn3-like domain (DUF1034) Glyco_hydro_31 PF01055.21 CCF45496.1 - 1.6e-80 271.1 0.4 2e-80 270.7 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 CCF45496.1 - 8.9e-14 51.1 0.0 2.9e-13 49.4 0.0 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like Cyt-b5 PF00173.23 CCF45497.1 - 0.019 14.7 0.0 1.1 9.0 0.0 2.4 2 0 0 2 2 2 0 Cytochrome b5-like Heme/Steroid binding domain KRTDAP PF15200.1 CCF45498.1 - 0.029 14.1 0.0 0.037 13.8 0.0 1.1 1 0 0 1 1 1 0 Keratinocyte differentiation-associated Fungal_trans PF04082.13 CCF45500.1 - 5.6e-13 48.3 0.2 8.4e-13 47.7 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF45500.1 - 4.8e-08 32.7 10.7 1.1e-07 31.5 7.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2477 PF10631.4 CCF45501.1 - 0.49 10.6 3.5 0.95 9.6 0.0 2.7 3 1 0 3 3 3 0 Protein of unknown function (DUF2477) Cu-oxidase_2 PF07731.9 CCF45502.1 - 9.1e-44 148.3 7.9 7.1e-42 142.1 0.9 3.8 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.10 CCF45502.1 - 4.9e-41 139.1 11.7 8.2e-41 138.4 1.3 4.0 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.17 CCF45502.1 - 7.3e-34 116.9 3.4 7.6e-34 116.9 0.1 2.8 4 0 0 4 4 4 1 Multicopper oxidase VTC PF09359.5 CCF45502.1 - 0.056 12.4 0.0 0.073 12.0 0.0 1.2 1 0 0 1 1 1 0 VTC domain Perilipin PF03036.11 CCF45503.1 - 0.00045 19.1 0.0 0.00053 18.9 0.0 1.1 1 0 0 1 1 1 1 Perilipin family Acyl-CoA_dh_N PF02771.11 CCF45505.1 - 1.9e-19 70.2 0.7 1.9e-19 70.2 0.5 1.4 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Nrap PF03813.9 CCF45506.1 - 2.2e-37 128.1 0.1 2.7e-37 127.8 0.0 1.0 1 0 0 1 1 1 1 Nrap protein Zn_clus PF00172.13 CCF45507.1 - 8.6e-09 35.1 10.9 1.4e-08 34.5 7.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF45507.1 - 2.7e-05 22.9 0.0 3.3e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Cyt-b5 PF00173.23 CCF45508.1 - 1.1e-09 37.8 0.0 2.1e-09 37.0 0.0 1.5 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Protocadherin PF08374.6 CCF45508.1 - 0.078 12.6 0.2 0.13 11.8 0.1 1.3 1 0 0 1 1 1 0 Protocadherin AOX PF01786.12 CCF45511.1 - 1e-43 149.1 0.0 1.4e-43 148.7 0.0 1.1 1 0 0 1 1 1 1 Alternative oxidase Pkinase PF00069.20 CCF45512.1 - 2.2e-71 240.0 0.0 3.8e-71 239.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF45512.1 - 6.6e-34 117.1 0.1 2.4e-33 115.3 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF45512.1 - 0.00011 21.2 0.0 0.00019 20.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CCF45512.1 - 0.00022 21.0 0.0 0.0028 17.4 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CCF45512.1 - 0.0036 16.9 0.3 0.0036 16.9 0.2 2.1 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kdo PF06293.9 CCF45512.1 - 0.028 13.5 0.0 0.058 12.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Malate_synthase PF01274.17 CCF45513.1 - 8.9e-225 746.6 0.0 1e-224 746.4 0.0 1.0 1 0 0 1 1 1 1 Malate synthase Aldolase_2 PF10120.4 CCF45514.1 - 0.1 11.9 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Putative aldolase Chorein_N PF12624.2 CCF45518.1 - 0.13 11.7 0.0 0.18 11.3 0.0 1.1 1 0 0 1 1 1 0 N-terminal region of Chorein, a TM vesicle-mediated sorter Glyco_hydro_18 PF00704.23 CCF45519.1 - 7.1e-93 311.7 0.9 8.2e-93 311.5 0.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DNA_pol_B PF00136.16 CCF45520.1 - 2.7e-19 69.3 0.2 2.9e-19 69.2 0.1 1.0 1 0 0 1 1 1 1 DNA polymerase family B DUF1399 PF07173.7 CCF45521.1 - 0.00013 22.2 0.0 0.00022 21.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1399) DZR PF12773.2 CCF45521.1 - 0.19 11.5 3.4 1.2 8.9 1.1 2.3 2 0 0 2 2 2 0 Double zinc ribbon zinc_ribbon_5 PF13719.1 CCF45521.1 - 0.55 9.8 2.3 2.6 7.6 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Sugar_tr PF00083.19 CCF45524.1 - 1.6e-06 27.0 0.2 1.8e-06 26.8 0.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter AChE_tetra PF08674.5 CCF45524.1 - 0.077 12.5 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 Acetylcholinesterase tetramerisation domain DUF2235 PF09994.4 CCF45525.1 - 6.8e-69 232.3 1.0 3.9e-67 226.5 0.7 2.3 1 1 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) DTW PF03942.10 CCF45525.1 - 0.025 13.7 0.0 0.047 12.9 0.0 1.3 1 0 0 1 1 1 0 DTW domain Acyl-CoA_dh_1 PF00441.19 CCF45526.1 - 1.1e-24 87.3 3.3 1.7e-24 86.6 2.3 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 CCF45526.1 - 3.2e-09 36.1 0.1 9.5e-09 34.6 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.11 CCF45526.1 - 6.8e-08 33.0 0.3 1.5e-07 31.9 0.2 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 CCF45526.1 - 1.3e-07 31.8 3.3 1.3e-07 31.8 2.3 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Equine_IAV_S2 PF06502.6 CCF45526.1 - 0.0077 16.0 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 Equine infectious anaemia virus S2 protein MFS_1 PF07690.11 CCF45527.1 - 1.8e-06 26.9 17.9 2.7e-06 26.3 7.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF962 PF06127.6 CCF45527.1 - 0.09 12.6 1.1 0.46 10.3 0.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF962) MFS_1_like PF12832.2 CCF45527.1 - 0.098 12.4 1.6 0.31 10.8 0.0 2.2 2 0 0 2 2 2 0 MFS_1 like family Vfa1 PF08432.5 CCF45528.1 - 0.99 9.4 42.7 1.4 8.8 29.6 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Ycf1 PF05758.7 CCF45528.1 - 1.1 6.9 41.1 1.2 6.7 28.5 1.0 1 0 0 1 1 1 0 Ycf1 GAGA_bind PF06217.7 CCF45528.1 - 1.8 8.4 40.5 2.1 8.2 28.1 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family PA26 PF04636.8 CCF45528.1 - 5.1 5.6 29.8 5.5 5.5 20.6 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Herpes_UL87 PF03043.9 CCF45528.1 - 9 4.5 24.0 10 4.3 16.6 1.2 1 0 0 1 1 1 0 Herpesvirus UL87 family Fungal_trans_2 PF11951.3 CCF45529.1 - 1.6e-08 33.5 0.8 2.7e-08 32.8 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Hus1 PF04005.7 CCF45530.1 - 1.5e-94 316.2 0.0 1.7e-94 316.0 0.0 1.0 1 0 0 1 1 1 1 Hus1-like protein NIPSNAP PF07978.8 CCF45532.1 - 6.3e-21 74.2 4.6 9.6e-12 44.7 0.1 2.7 3 0 0 3 3 3 2 NIPSNAP ASD2 PF08687.6 CCF45532.1 - 0.0064 15.8 1.1 0.01 15.1 0.7 1.3 1 0 0 1 1 1 1 Apx/Shroom domain ASD2 Vma12 PF11712.3 CCF45532.1 - 0.01 15.5 0.6 0.019 14.6 0.4 1.4 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase SR-25 PF10500.4 CCF45532.1 - 2.5 7.4 12.1 4.2 6.7 8.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MAP7 PF05672.6 CCF45533.1 - 0.011 15.1 1.1 0.015 14.6 0.8 1.1 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family DUF2264 PF10022.4 CCF45534.1 - 2.7e-95 319.0 1.8 3.7e-95 318.6 1.3 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) GMC_oxred_C PF05199.8 CCF45535.1 - 1.8e-14 54.2 0.3 2e-14 54.0 0.2 1.0 1 0 0 1 1 1 1 GMC oxidoreductase Sugar_tr PF00083.19 CCF45536.1 - 1.2e-105 353.7 25.2 2.5e-105 352.6 17.5 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF45536.1 - 1.2e-22 80.1 53.2 9.2e-16 57.4 20.4 2.6 1 1 2 3 3 3 2 Major Facilitator Superfamily DUF2207 PF09972.4 CCF45536.1 - 0.059 11.9 3.8 0.38 9.2 0.0 2.5 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF910 PF06014.6 CCF45536.1 - 0.081 12.8 0.1 0.24 11.3 0.0 1.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF910) DUF89 PF01937.14 CCF45537.1 - 4e-134 446.9 0.0 4.6e-134 446.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 adh_short_C2 PF13561.1 CCF45539.1 - 2.5e-17 63.4 0.0 3.3e-17 63.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ZapA PF05164.8 CCF45541.1 - 0.009 15.9 0.6 0.013 15.4 0.4 1.3 1 1 0 1 1 1 1 Cell division protein ZapA Lactamase_B PF00753.22 CCF45542.1 - 3.2e-27 95.4 0.8 3.4e-26 92.0 0.6 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CCF45542.1 - 1.1e-06 28.3 0.1 1.5e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 CCF45542.1 - 0.00099 18.8 0.1 0.0012 18.6 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Peripla_BP_4 PF13407.1 CCF45542.1 - 0.015 14.6 0.3 0.026 13.8 0.2 1.4 1 0 0 1 1 1 0 Periplasmic binding protein domain LVIVD PF08309.6 CCF45542.1 - 0.026 13.4 0.3 0.048 12.6 0.2 1.3 1 0 0 1 1 1 0 LVIVD repeat BcrAD_BadFG PF01869.15 CCF45542.1 - 0.085 12.1 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family bZIP_1 PF00170.16 CCF45543.1 - 0.00048 20.0 10.7 0.0025 17.7 0.2 3.7 2 1 1 3 3 3 1 bZIP transcription factor Myosin_tail_1 PF01576.14 CCF45543.1 - 0.0014 16.4 12.6 0.012 13.4 8.8 2.0 1 1 0 1 1 1 1 Myosin tail CENP-F_leu_zip PF10473.4 CCF45543.1 - 0.0069 16.2 8.0 0.0069 16.2 5.6 2.5 2 1 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AKNA PF12443.3 CCF45543.1 - 0.014 15.3 7.2 0.36 10.8 0.6 3.3 1 1 1 2 2 2 0 AT-hook-containing transcription factor Bacillus_HBL PF05791.6 CCF45543.1 - 0.017 14.5 2.3 0.19 11.1 0.8 2.3 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) HAUS-augmin3 PF14932.1 CCF45543.1 - 0.022 13.9 7.3 0.082 12.0 4.9 1.9 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 Spc24 PF08286.6 CCF45543.1 - 0.044 13.4 5.7 0.53 9.9 0.5 3.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 ERM PF00769.14 CCF45543.1 - 0.065 12.7 11.1 0.15 11.5 7.7 1.6 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF4200 PF13863.1 CCF45543.1 - 0.09 12.7 11.4 0.75 9.7 0.7 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) IncA PF04156.9 CCF45543.1 - 0.091 12.3 16.4 0.3 10.6 11.4 1.9 1 1 0 1 1 1 0 IncA protein DUF4201 PF13870.1 CCF45543.1 - 0.094 12.1 8.4 0.38 10.1 5.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) EzrA PF06160.7 CCF45543.1 - 0.11 10.7 9.0 0.18 9.9 5.8 1.6 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Reo_sigmaC PF04582.7 CCF45543.1 - 0.11 11.6 2.1 0.24 10.5 1.4 1.5 1 0 0 1 1 1 0 Reovirus sigma C capsid protein ATG16 PF08614.6 CCF45543.1 - 0.17 11.6 13.0 1.4 8.7 9.0 2.5 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Lge1 PF11488.3 CCF45543.1 - 0.17 12.0 3.9 0.85 9.8 0.4 2.7 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 ADIP PF11559.3 CCF45543.1 - 0.24 11.2 13.0 2.8 7.8 1.8 2.9 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding TPR_MLP1_2 PF07926.7 CCF45543.1 - 0.28 10.9 11.3 0.16 11.6 4.9 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein APG6 PF04111.7 CCF45543.1 - 0.3 10.0 12.2 0.6 9.1 8.4 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 K-box PF01486.12 CCF45543.1 - 0.4 10.5 11.3 0.33 10.7 0.2 3.1 4 0 0 4 4 2 0 K-box region Atg14 PF10186.4 CCF45543.1 - 0.43 9.4 14.4 0.81 8.5 10.0 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Shugoshin_N PF07558.6 CCF45543.1 - 0.67 9.7 5.1 0.14 11.8 0.5 2.2 2 0 0 2 2 1 0 Shugoshin N-terminal coiled-coil region Spc7 PF08317.6 CCF45543.1 - 0.81 8.2 10.5 0.66 8.5 2.2 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein TMF_DNA_bd PF12329.3 CCF45543.1 - 0.99 9.2 17.3 0.29 10.9 0.8 3.6 4 0 0 4 4 4 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.10 CCF45543.1 - 1 8.8 13.4 1.1 8.7 1.7 3.5 2 1 1 3 3 3 0 Septum formation initiator TBPIP PF07106.8 CCF45543.1 - 1.2 8.6 6.2 2.4 7.6 2.7 2.4 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) IFT57 PF10498.4 CCF45543.1 - 1.2 7.7 10.0 0.17 10.6 3.8 1.7 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Bap31 PF05529.7 CCF45543.1 - 1.3 8.3 6.8 2.5 7.5 1.7 2.3 1 1 1 2 2 2 0 B-cell receptor-associated protein 31-like Halogen_Hydrol PF10112.4 CCF45543.1 - 1.5 8.1 8.7 6.7 6.0 0.7 3.5 2 2 1 4 4 4 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein MscS_porin PF12795.2 CCF45543.1 - 1.6 7.9 18.5 0.34 10.1 6.7 2.8 2 1 0 2 2 2 0 Mechanosensitive ion channel porin domain GrpE PF01025.14 CCF45543.1 - 1.7 8.1 10.6 4.6 6.7 2.2 2.9 2 1 1 3 3 3 0 GrpE DUF904 PF06005.7 CCF45543.1 - 2 8.7 10.1 38 4.6 4.3 3.6 2 1 0 2 2 2 0 Protein of unknown function (DUF904) Mnd1 PF03962.10 CCF45543.1 - 2.8 7.5 10.8 14 5.2 7.6 2.2 1 1 1 2 2 2 0 Mnd1 family DUF641 PF04859.7 CCF45543.1 - 3.1 7.5 10.0 6.4 6.5 2.4 3.3 2 1 2 4 4 4 0 Plant protein of unknown function (DUF641) V_ATPase_I PF01496.14 CCF45543.1 - 3.3 5.4 4.8 5.4 4.7 3.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF724 PF05266.9 CCF45543.1 - 3.6 7.1 9.0 2 8.0 3.4 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF724) DUF4407 PF14362.1 CCF45543.1 - 4.8 6.0 8.6 19 4.1 6.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Uds1 PF15456.1 CCF45543.1 - 6.2 6.8 14.2 3.3 7.7 5.8 2.8 1 1 1 2 2 2 0 Up-regulated During Septation Viral_P18 PF04521.8 CCF45543.1 - 6.7 6.1 8.3 3.7 7.0 0.6 2.8 1 1 2 3 3 3 0 ssRNA positive strand viral 18kD cysteine rich protein bZIP_2 PF07716.10 CCF45543.1 - 8.5 6.2 15.4 2 8.3 0.5 3.9 3 0 0 3 3 3 0 Basic region leucine zipper PUF PF00806.14 CCF45544.1 - 2.3e-13 48.8 0.1 0.026 13.9 0.0 5.4 5 0 0 5 5 5 5 Pumilio-family RNA binding repeat Gemini_AL1_M PF08283.6 CCF45546.1 - 0.00013 21.7 0.0 0.00029 20.6 0.0 1.6 2 0 0 2 2 2 1 Geminivirus rep protein central domain Rap1_C PF11626.3 CCF45546.1 - 0.11 12.4 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Spc7 PF08317.6 CCF45547.1 - 0.00075 18.2 1.2 0.001 17.7 0.8 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein IncA PF04156.9 CCF45547.1 - 0.00082 19.0 1.6 0.0012 18.4 1.1 1.2 1 0 0 1 1 1 1 IncA protein DUF3552 PF12072.3 CCF45547.1 - 0.0084 15.3 0.7 0.013 14.6 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) Sec2p PF06428.6 CCF45547.1 - 0.021 14.6 2.6 0.043 13.6 1.8 1.5 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p AAA_13 PF13166.1 CCF45547.1 - 0.03 12.8 0.2 0.039 12.4 0.1 1.1 1 0 0 1 1 1 0 AAA domain BicD PF09730.4 CCF45547.1 - 0.25 9.6 9.7 0.02 13.2 3.6 1.6 1 1 1 2 2 2 0 Microtubule-associated protein Bicaudal-D Cwf_Cwc_15 PF04889.7 CCF45547.1 - 1.3 8.7 7.9 0.22 11.2 2.7 1.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein MscS_porin PF12795.2 CCF45547.1 - 1.3 8.2 14.4 5.9 6.1 9.6 2.0 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain DUF812 PF05667.6 CCF45547.1 - 5.7 5.3 15.4 7.3 4.9 10.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) SBP_bac_6 PF13343.1 CCF45548.1 - 5.2e-14 52.1 0.5 7.2e-14 51.6 0.4 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.1 CCF45548.1 - 3.4e-06 26.8 0.1 4.2e-06 26.5 0.0 1.3 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.20 CCF45548.1 - 0.015 15.0 4.6 0.039 13.6 3.2 1.7 1 1 0 1 1 1 0 Bacterial extracellular solute-binding protein Ank_2 PF12796.2 CCF45549.1 - 1.5e-18 66.9 0.2 2.8e-06 27.5 0.0 4.4 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 CCF45549.1 - 7e-14 50.8 7.3 1.3e-06 27.8 0.0 6.3 6 1 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.1 CCF45549.1 - 1.2e-10 41.2 3.7 5.5e-05 23.2 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 CCF45549.1 - 8.3e-07 29.3 1.1 0.0027 18.1 0.0 4.5 4 1 2 6 6 6 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF45549.1 - 1.2e-06 28.1 0.1 0.79 10.1 0.0 5.3 4 0 0 4 4 4 1 Ankyrin repeat NACHT PF05729.7 CCF45549.1 - 6.2e-05 22.7 1.9 0.00049 19.7 0.3 2.8 2 1 0 2 2 2 1 NACHT domain AAA_19 PF13245.1 CCF45549.1 - 0.026 14.2 0.1 0.084 12.6 0.1 1.9 1 0 0 1 1 1 0 Part of AAA domain UPF0079 PF02367.12 CCF45549.1 - 0.12 12.0 0.0 0.31 10.6 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 ATP12 PF07542.6 CCF45551.1 - 4.5e-18 65.3 0.3 9e-18 64.3 0.1 1.6 2 0 0 2 2 2 1 ATP12 chaperone protein UnbV_ASPIC PF07593.7 CCF45551.1 - 0.048 13.3 1.0 0.2 11.3 0.1 2.1 1 1 1 2 2 2 0 ASPIC and UnbV DFP PF04127.10 CCF45552.1 - 0.0052 16.4 0.2 0.0072 15.9 0.1 1.2 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein ApoO PF09769.4 CCF45552.1 - 0.11 12.1 0.0 0.11 12.1 0.0 1.1 1 0 0 1 1 1 0 Apolipoprotein O MFS_1 PF07690.11 CCF45554.1 - 4.7e-13 48.5 19.3 4.7e-13 48.5 13.4 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF45554.1 - 0.0015 17.2 17.3 0.0015 17.2 12.0 1.9 1 1 1 2 2 2 1 Sugar (and other) transporter PX PF00787.19 CCF45555.1 - 2.4e-21 75.6 0.2 2.4e-21 75.6 0.2 1.7 2 0 0 2 2 2 1 PX domain Vps5 PF09325.5 CCF45555.1 - 0.0005 19.4 0.9 0.00079 18.7 0.6 1.4 1 0 0 1 1 1 1 Vps5 C terminal like Reo_sigmaC PF04582.7 CCF45555.1 - 0.023 13.9 0.0 0.036 13.2 0.0 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein IncA PF04156.9 CCF45555.1 - 0.024 14.2 0.6 0.034 13.7 0.4 1.2 1 0 0 1 1 1 0 IncA protein Occludin_ELL PF07303.8 CCF45555.1 - 0.043 14.5 0.1 0.21 12.3 0.0 2.2 2 1 0 2 2 2 0 Occludin homology domain DUF3140 PF11338.3 CCF45555.1 - 0.092 12.8 1.4 0.2 11.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3140) Zip PF02535.17 CCF45556.1 - 8.2e-47 159.7 0.0 1.1e-46 159.3 0.0 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter AIG2 PF06094.7 CCF45558.1 - 3.1e-09 37.2 0.0 5.8e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 AIG2-like family Stb3 PF10330.4 CCF45559.1 - 3.9e-37 125.8 0.0 6.1e-37 125.2 0.0 1.3 1 0 0 1 1 1 1 Putative Sin3 binding protein NmrA PF05368.8 CCF45560.1 - 3.5e-28 98.4 0.0 8.3e-28 97.2 0.0 1.6 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF45560.1 - 3.3e-12 46.7 0.2 5.1e-12 46.1 0.2 1.3 1 0 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 CCF45560.1 - 3.1e-05 23.9 1.5 3.1e-05 23.9 1.0 1.8 3 0 0 3 3 3 1 short chain dehydrogenase Epimerase PF01370.16 CCF45560.1 - 0.00026 20.5 0.0 0.00038 19.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.12 CCF45560.1 - 0.0029 17.9 0.1 0.0054 17.1 0.1 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent KR PF08659.5 CCF45560.1 - 0.0037 16.9 0.3 0.007 16.0 0.2 1.4 1 0 0 1 1 1 1 KR domain Saccharop_dh PF03435.13 CCF45560.1 - 0.017 14.1 0.0 0.023 13.6 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase 3Beta_HSD PF01073.14 CCF45560.1 - 0.022 13.4 0.0 0.033 12.9 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short_C2 PF13561.1 CCF45561.1 - 1.3e-22 80.8 0.0 2.2e-22 80.0 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CCF45561.1 - 1.6e-21 76.9 1.5 2.1e-21 76.5 1.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF45561.1 - 2.9e-09 36.8 0.4 4.2e-09 36.3 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF45561.1 - 0.00046 19.7 0.5 0.00093 18.6 0.1 1.8 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.13 CCF45561.1 - 0.035 13.7 0.6 0.048 13.2 0.4 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Hydantoinase_A PF01968.13 CCF45562.1 - 3.7e-62 210.0 1.0 1.8e-61 207.7 0.0 2.2 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 CCF45562.1 - 5.5e-54 182.3 0.4 8.1e-52 175.2 0.0 2.2 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Epimerase PF01370.16 CCF45563.1 - 1.6e-31 109.5 0.0 2.3e-31 109.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 CCF45563.1 - 1.1e-08 34.3 0.0 1.4e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 CCF45563.1 - 7.7e-08 31.5 0.0 1.1e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.10 CCF45563.1 - 5.1e-05 22.3 0.0 6.8e-05 21.9 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 CCF45563.1 - 0.011 14.4 0.0 0.015 14.0 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Bac_globin PF01152.16 CCF45565.1 - 0.52 10.3 2.1 0.87 9.6 0.9 1.7 1 1 0 1 1 1 0 Bacterial-like globin Pkinase PF00069.20 CCF45566.1 - 0.00014 21.1 0.0 0.00099 18.3 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain PDEase_II PF02112.10 CCF45569.1 - 5.2e-49 166.9 0.0 8.5e-41 139.9 0.0 3.1 2 1 0 2 2 2 2 cAMP phosphodiesterases class-II Lactamase_B PF00753.22 CCF45569.1 - 0.032 13.8 1.8 0.1 12.2 1.2 1.9 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CCF45569.1 - 0.069 12.6 0.0 0.12 11.9 0.0 1.5 1 1 0 1 1 1 0 Beta-lactamase superfamily domain Abhydrolase_6 PF12697.2 CCF45570.1 - 0.0094 15.8 0.6 0.014 15.2 0.4 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Pkinase PF00069.20 CCF45571.1 - 3.9e-12 45.8 0.0 5.1e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF45571.1 - 0.0071 15.4 0.0 0.0099 14.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase XPG_I PF00867.13 CCF45572.1 - 7.6e-27 93.2 0.0 2.1e-26 91.7 0.0 1.8 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.2 CCF45572.1 - 0.0022 17.5 0.6 0.013 15.0 0.0 2.2 1 1 1 2 2 2 1 XPG domain containing 5_3_exonuc PF01367.15 CCF45572.1 - 0.039 14.1 0.5 0.12 12.5 0.0 2.2 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold HHH PF00633.18 CCF45572.1 - 0.23 11.2 0.9 0.71 9.6 0.1 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix motif adh_short PF00106.20 CCF45574.1 - 6.7e-17 61.9 6.5 1.1e-16 61.2 2.9 2.2 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF45574.1 - 7.2e-14 52.1 1.7 2.8e-13 50.1 1.2 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 CCF45574.1 - 1.9e-06 27.9 0.1 3.5e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF45574.1 - 3.3e-05 23.2 0.0 6.4e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 NmrA-like family NAD_binding_2 PF03446.10 CCF45574.1 - 0.00018 21.3 0.0 0.00044 20.1 0.0 1.7 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DUF1776 PF08643.5 CCF45574.1 - 0.00061 19.0 0.0 0.00098 18.3 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) DFP PF04127.10 CCF45574.1 - 0.0028 17.3 0.1 0.0053 16.3 0.1 1.4 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein ApbA PF02558.11 CCF45574.1 - 0.026 13.9 0.0 0.045 13.2 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.13 CCF45574.1 - 0.076 12.6 0.0 0.18 11.4 0.0 1.7 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PP-binding PF00550.20 CCF45575.1 - 9.3e-06 25.8 0.0 1.2e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site p450 PF00067.17 CCF45576.1 - 8.3e-58 196.0 0.0 9.4e-58 195.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Terpene_synth PF01397.16 CCF45576.1 - 0.088 12.1 0.1 0.3 10.4 0.1 1.8 2 0 0 2 2 2 0 Terpene synthase, N-terminal domain NAD_binding_11 PF14833.1 CCF45578.1 - 1.3e-30 105.9 0.0 1.5e-30 105.7 0.0 1.0 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase DUF3812 PF12757.2 CCF45579.1 - 0.024 14.6 0.2 0.035 14.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3812) Brix PF04427.13 CCF45580.1 - 1.4e-35 122.6 0.1 1.9e-35 122.2 0.0 1.1 1 0 0 1 1 1 1 Brix domain DUF1072 PF06380.6 CCF45581.1 - 1.7 8.3 6.3 0.22 11.2 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1072) ABC_tran PF00005.22 CCF45582.1 - 3.7e-46 156.8 0.0 1.2e-24 87.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 CCF45582.1 - 2.5e-38 132.0 17.1 4.8e-24 85.2 6.2 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.14 CCF45582.1 - 9.3e-11 41.3 0.2 0.00015 21.0 0.0 4.2 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF45582.1 - 1.2e-08 35.3 0.2 0.073 13.0 0.0 4.2 3 1 1 4 4 4 2 AAA domain T2SE PF00437.15 CCF45582.1 - 1e-07 31.1 0.1 0.0003 19.7 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_29 PF13555.1 CCF45582.1 - 6.7e-07 28.7 2.1 0.035 13.6 0.2 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.1 CCF45582.1 - 1.5e-06 27.7 0.1 0.067 12.5 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.1 CCF45582.1 - 3.5e-06 27.1 0.9 0.0011 18.9 0.1 2.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 CCF45582.1 - 1.3e-05 25.3 0.3 0.16 12.0 0.0 3.3 2 1 0 2 2 2 2 AAA domain FtsK_SpoIIIE PF01580.13 CCF45582.1 - 2.8e-05 23.6 0.1 0.0097 15.3 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_23 PF13476.1 CCF45582.1 - 0.00047 20.5 0.1 0.75 10.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 CCF45582.1 - 0.0012 18.0 0.1 0.79 8.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Miro PF08477.8 CCF45582.1 - 0.0014 19.1 0.2 1.5 9.3 0.0 2.6 2 0 0 2 2 2 1 Miro-like protein AAA_10 PF12846.2 CCF45582.1 - 0.0015 18.0 0.1 0.82 9.0 0.0 2.3 2 0 0 2 2 2 1 AAA-like domain MMR_HSR1 PF01926.18 CCF45582.1 - 0.0042 17.0 0.0 1.3 8.9 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.12 CCF45582.1 - 0.008 15.7 0.0 3.1 7.2 0.0 2.4 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_19 PF13245.1 CCF45582.1 - 0.0089 15.7 3.2 0.52 10.0 0.0 4.6 5 0 0 5 5 4 1 Part of AAA domain AAA_33 PF13671.1 CCF45582.1 - 0.011 15.5 0.0 3 7.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 CCF45582.1 - 0.017 15.9 2.0 5.1 7.9 0.2 2.8 2 0 0 2 2 2 0 AAA domain cobW PF02492.14 CCF45582.1 - 0.024 14.1 0.8 4.4 6.7 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.12 CCF45582.1 - 0.025 14.4 1.0 0.42 10.3 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF87 MobB PF03205.9 CCF45582.1 - 0.031 14.0 0.4 6.3 6.5 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B TrwB_AAD_bind PF10412.4 CCF45582.1 - 0.034 12.7 0.5 1.4 7.4 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Zeta_toxin PF06414.7 CCF45582.1 - 0.035 13.2 0.0 2.4 7.1 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin DEAD PF00270.24 CCF45582.1 - 0.036 13.5 1.5 5 6.5 0.0 3.2 4 0 0 4 4 2 0 DEAD/DEAH box helicase NTPase_1 PF03266.10 CCF45582.1 - 0.053 13.2 1.1 15 5.2 0.0 3.3 3 0 0 3 3 3 0 NTPase AAA_18 PF13238.1 CCF45582.1 - 0.054 13.8 0.2 5.3 7.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.13 CCF45582.1 - 0.059 12.8 0.0 11 5.4 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase NACHT PF05729.7 CCF45582.1 - 0.07 12.7 1.3 2.9 7.5 0.0 3.1 3 0 0 3 3 2 0 NACHT domain Arch_ATPase PF01637.13 CCF45582.1 - 0.071 12.8 0.1 0.8 9.3 0.0 2.2 2 0 0 2 2 2 0 Archaeal ATPase ArgK PF03308.11 CCF45582.1 - 0.078 11.7 0.1 0.91 8.2 0.0 2.2 2 0 0 2 2 2 0 ArgK protein NB-ARC PF00931.17 CCF45582.1 - 0.13 11.1 2.8 6.3 5.5 0.0 3.2 4 0 0 4 4 4 0 NB-ARC domain RNA_helicase PF00910.17 CCF45582.1 - 0.28 11.3 0.4 64 3.7 0.0 3.3 3 0 0 3 3 3 0 RNA helicase AAA_30 PF13604.1 CCF45582.1 - 0.47 9.9 2.4 23 4.5 0.0 3.0 4 0 0 4 4 2 0 AAA domain Utp14 PF04615.8 CCF45582.1 - 1.1 7.3 0.2 1.7 6.7 0.2 1.2 1 0 0 1 1 1 0 Utp14 protein DAP3 PF10236.4 CCF45582.1 - 1.2 7.9 2.5 8 5.2 0.1 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 adh_short PF00106.20 CCF45583.1 - 4.5e-17 62.4 0.7 5.8e-17 62.1 0.5 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF45583.1 - 1e-08 35.0 0.2 2.3e-08 33.9 0.1 1.5 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.1 CCF45583.1 - 3.6e-06 26.9 0.0 4.7e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.3 CCF45583.1 - 0.0012 18.5 0.3 0.0027 17.4 0.2 1.5 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Epimerase PF01370.16 CCF45583.1 - 0.0036 16.7 0.1 0.0067 15.8 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 CCF45583.1 - 0.009 14.9 0.0 0.012 14.5 0.0 1.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_3 PF03447.11 CCF45583.1 - 0.11 12.9 0.1 0.18 12.2 0.1 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain TauD PF02668.11 CCF45586.1 - 4.4e-56 190.4 0.2 5.5e-56 190.1 0.2 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Carn_acyltransf PF00755.15 CCF45587.1 - 1.4e-15 56.4 1.2 1.8e-15 56.1 0.8 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Catalase-rel PF06628.7 CCF45588.1 - 6.9e-21 73.8 0.0 1.2e-20 73.1 0.0 1.4 1 0 0 1 1 1 1 Catalase-related immune-responsive PALP PF00291.20 CCF45589.1 - 0.047 12.9 0.0 0.063 12.4 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme SMP PF04927.7 CCF45590.1 - 0.0001 22.2 3.8 0.00014 21.7 2.6 1.3 1 0 0 1 1 1 1 Seed maturation protein Trypan_PARP PF05887.6 CCF45590.1 - 0.67 9.7 4.0 0.68 9.7 2.8 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Ank_2 PF12796.2 CCF45591.1 - 0.016 15.5 0.0 0.024 14.9 0.0 1.3 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF45591.1 - 0.019 15.4 0.0 0.033 14.7 0.0 1.4 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Thioredoxin PF00085.15 CCF45592.1 - 1.2e-42 143.7 0.2 1.9e-24 85.3 0.0 3.2 3 1 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.1 CCF45592.1 - 6e-12 45.7 0.0 7.8e-05 22.5 0.0 3.8 2 1 2 4 4 4 3 Thioredoxin-like domain Thioredoxin_2 PF13098.1 CCF45592.1 - 5.6e-09 36.1 0.6 0.0012 19.0 0.1 4.3 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 CCF45592.1 - 3.9e-06 26.9 0.7 0.0013 18.8 0.0 3.7 3 1 0 3 3 3 1 Thioredoxin-like Thioredoxin_7 PF13899.1 CCF45592.1 - 8.1e-05 22.5 0.5 0.0012 18.7 0.1 2.9 3 0 0 3 3 3 1 Thioredoxin-like HyaE PF07449.6 CCF45592.1 - 0.0014 18.4 0.0 8.8 6.2 0.0 4.3 4 0 0 4 4 4 1 Hydrogenase-1 expression protein HyaE AhpC-TSA PF00578.16 CCF45592.1 - 0.016 14.8 0.9 0.15 11.7 0.0 2.9 3 0 0 3 3 3 0 AhpC/TSA family Thioredoxin_3 PF13192.1 CCF45592.1 - 0.026 14.3 0.9 0.46 10.3 0.0 3.4 5 0 0 5 5 5 0 Thioredoxin domain 7TM_GPCR_Srh PF10318.4 CCF45592.1 - 0.085 11.6 0.0 0.16 10.7 0.0 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srh DUF4349 PF14257.1 CCF45592.1 - 1 8.4 0.0 1 8.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) PLDc_2 PF13091.1 CCF45593.1 - 2e-15 56.6 0.0 1.8e-05 24.4 0.0 4.1 3 1 0 3 3 3 2 PLD-like domain PLDc PF00614.17 CCF45593.1 - 2.2e-10 39.9 0.8 0.00029 20.5 0.0 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif Acetyltransf_1 PF00583.19 CCF45594.1 - 7.4e-07 29.1 0.4 2.2e-06 27.5 0.0 1.9 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF45594.1 - 2.6e-06 27.4 0.0 2.5e-05 24.3 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CCF45594.1 - 7.9e-05 22.7 0.0 0.00044 20.3 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF45594.1 - 0.006 16.3 0.1 0.035 13.8 0.1 2.0 1 1 0 1 1 1 1 FR47-like protein p450 PF00067.17 CCF45595.1 - 8.7e-26 90.4 0.0 1.3e-25 89.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Alk_phosphatase PF00245.15 CCF45597.1 - 1.7e-92 310.3 0.0 2.3e-92 309.8 0.0 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.13 CCF45597.1 - 0.00055 19.4 0.0 0.00097 18.5 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF3169 PF11368.3 CCF45598.1 - 0.087 12.0 0.0 3.9 6.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) DUF4395 PF14340.1 CCF45598.1 - 1.8 8.6 7.9 4.2 7.4 5.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4395) DUF484 PF04340.7 CCF45599.1 - 0.11 11.9 0.1 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF484 HECT PF00632.20 CCF45600.1 - 2.5e-69 233.8 0.0 3.5e-69 233.3 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) 2OG-FeII_Oxy_3 PF13640.1 CCF45601.1 - 5.4e-10 39.6 0.0 8.6e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 CCF45601.1 - 2.9e-07 30.0 0.1 6.1e-07 28.9 0.0 1.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 CCF45601.1 - 0.017 15.3 0.0 0.031 14.5 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DUF218 PF02698.12 CCF45603.1 - 2.8e-11 43.1 0.0 1.1e-10 41.2 0.0 1.9 3 0 0 3 3 3 1 DUF218 domain Tyrosinase PF00264.15 CCF45604.1 - 1.6e-39 136.4 0.7 2.1e-39 135.9 0.5 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase DUF3328 PF11807.3 CCF45605.1 - 0.0047 16.6 0.2 0.0084 15.8 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Mannosyl_trans3 PF11051.3 CCF45606.1 - 2.9e-60 203.9 0.0 3.5e-60 203.6 0.0 1.1 1 0 0 1 1 1 1 Mannosyltransferase putative p47_phox_C PF08944.6 CCF45606.1 - 0.02 15.0 0.4 0.04 14.1 0.3 1.4 1 0 0 1 1 1 0 NADPH oxidase subunit p47Phox, C terminal domain p450 PF00067.17 CCF45607.1 - 3.9e-18 65.2 0.0 5.4e-18 64.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 HCV_core PF01542.13 CCF45608.1 - 0.0078 16.5 0.3 0.02 15.2 0.2 1.7 1 0 0 1 1 1 1 Hepatitis C virus core protein DUF4188 PF13826.1 CCF45610.1 - 1e-33 115.8 0.6 1.4e-33 115.4 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4188) Dehydratase_hem PF13816.1 CCF45610.1 - 0.00013 21.1 0.9 0.00043 19.4 0.3 1.6 1 1 1 2 2 2 1 Haem-containing dehydratase Dabb PF07876.7 CCF45610.1 - 0.13 12.6 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 Stress responsive A/B Barrel Domain Iso_dh PF00180.15 CCF45613.1 - 1.4e-133 445.1 0.0 1.6e-133 444.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase MFS_1 PF07690.11 CCF45615.1 - 1.3e-06 27.4 25.8 1.8e-05 23.6 17.9 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF45615.1 - 0.021 14.5 0.5 0.68 9.7 0.1 2.4 2 0 0 2 2 2 0 MFS_1 like family Cyt-b5 PF00173.23 CCF45620.1 - 0.14 11.9 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Cytochrome b5-like Heme/Steroid binding domain Fungal_trans PF04082.13 CCF45623.1 - 1.7e-23 82.8 0.1 2.1e-23 82.5 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain adh_short PF00106.20 CCF45626.1 - 6.5e-12 45.6 1.4 7.6e-12 45.4 0.2 1.7 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF45626.1 - 7.2e-05 22.6 0.0 9.8e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF45626.1 - 0.0019 17.9 0.2 0.0038 16.9 0.2 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF45626.1 - 0.0062 15.9 0.2 0.02 14.3 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Herpes_IE2_3 PF03361.9 CCF45626.1 - 0.13 11.5 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Herpes virus intermediate/early protein 2/3 Homeobox_KN PF05920.6 CCF45627.1 - 4.4e-14 51.8 1.8 9.6e-14 50.8 1.3 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.24 CCF45627.1 - 2.3e-09 36.7 1.4 3.8e-09 36.0 1.0 1.3 1 0 0 1 1 1 1 Homeobox domain Homez PF11569.3 CCF45627.1 - 0.0027 16.7 0.3 0.014 14.4 0.1 2.0 2 0 0 2 2 2 1 Homeodomain leucine-zipper encoding, Homez HA PF03457.9 CCF45627.1 - 0.11 12.5 0.1 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Helicase associated domain Pkinase_C PF00433.19 CCF45628.1 - 0.045 14.2 0.6 0.39 11.2 0.4 2.1 2 0 0 2 2 2 0 Protein kinase C terminal domain Acetyltransf_1 PF00583.19 CCF45629.1 - 2.4e-05 24.2 0.0 0.00011 22.0 0.0 2.0 1 1 1 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF45629.1 - 0.055 13.6 0.0 0.087 12.9 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DAO PF01266.19 CCF45630.1 - 0.019 13.8 0.0 0.033 13.0 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Rop PF01815.11 CCF45633.1 - 0.022 14.1 0.3 0.071 12.5 0.2 1.8 2 1 1 3 3 3 0 Rop protein GWT1 PF06423.7 CCF45635.1 - 2.5e-45 153.9 1.1 2.5e-45 153.9 0.8 1.9 2 0 0 2 2 2 1 GWT1 Trehalose_PPase PF02358.11 CCF45637.1 - 1.7e-23 82.8 0.0 1.8e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 Trehalose-phosphatase Prenyltrans PF00432.16 CCF45638.1 - 1.4e-32 110.9 8.7 1e-07 31.4 0.1 5.7 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 CCF45638.1 - 1.9e-18 66.9 0.0 1.4e-10 41.5 0.0 4.6 1 1 4 5 5 5 5 Prenyltransferase-like Prenyltrans_1 PF13243.1 CCF45638.1 - 0.0011 18.9 0.1 0.34 10.9 0.0 2.6 2 0 0 2 2 2 2 Prenyltransferase-like MFS_1 PF07690.11 CCF45639.1 - 3e-22 78.8 39.9 3.6e-22 78.5 27.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans PF04082.13 CCF45640.1 - 1e-14 54.0 0.0 1.8e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF45640.1 - 0.00013 21.8 11.2 0.00031 20.5 7.7 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.20 CCF45642.1 - 3e-24 85.8 0.6 4.6e-24 85.2 0.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF45642.1 - 2.7e-19 69.8 0.0 3.4e-19 69.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF45642.1 - 3.5e-08 33.3 0.1 5.2e-08 32.7 0.1 1.2 1 0 0 1 1 1 1 KR domain Ldh_1_N PF00056.18 CCF45642.1 - 0.0013 18.5 0.0 0.0039 17.0 0.0 1.7 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain HHH_5 PF14520.1 CCF45642.1 - 0.0064 16.6 0.1 0.073 13.2 0.1 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix domain Pkinase PF00069.20 CCF45643.1 - 9.7e-46 156.0 0.0 3e-45 154.4 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF45643.1 - 1.3e-31 109.6 0.0 1.9e-31 109.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF45643.1 - 0.0012 17.9 0.0 0.0019 17.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 CCF45643.1 - 0.072 12.1 0.0 0.38 9.7 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Y_phosphatase PF00102.22 CCF45649.1 - 3.1e-46 157.5 0.0 6.6e-46 156.5 0.0 1.5 1 1 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 CCF45649.1 - 0.0079 16.2 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate DSPc PF00782.15 CCF45649.1 - 0.023 14.2 0.0 0.048 13.2 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 CCF45649.1 - 0.032 14.4 0.0 0.055 13.7 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Period_C PF12114.3 CCF45649.1 - 0.13 11.8 1.5 0.24 10.9 1.0 1.4 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Transp_cyt_pur PF02133.10 CCF45650.1 - 1.7e-27 96.0 0.4 2.2e-27 95.7 0.3 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Ferric_reduct PF01794.14 CCF45652.1 - 2.2e-16 60.0 17.7 2.2e-16 60.0 12.2 2.0 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 CCF45652.1 - 6.9e-05 22.6 0.0 0.074 12.9 0.0 2.7 3 0 0 3 3 3 2 FAD-binding domain Dehydrin PF00257.14 CCF45652.1 - 0.19 12.0 6.0 1.1 9.6 0.8 2.2 2 0 0 2 2 2 0 Dehydrin ERG4_ERG24 PF01222.12 CCF45653.1 - 2.7e-144 480.8 16.0 3.2e-144 480.6 11.1 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Fungal_trans_2 PF11951.3 CCF45654.1 - 2.6e-09 36.1 0.7 2.6e-09 36.1 0.5 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Methyltransf_23 PF13489.1 CCF45655.1 - 9.8e-22 77.3 0.0 1.4e-21 76.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF45655.1 - 4.1e-10 40.2 0.0 6.8e-09 36.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF45655.1 - 2.4e-09 37.5 0.0 4.2e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF45655.1 - 5.3e-09 35.8 0.0 6.4e-08 32.3 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF45655.1 - 1.2e-06 28.8 0.0 5.6e-06 26.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF45655.1 - 5.7e-05 23.4 0.0 0.00013 22.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 CCF45655.1 - 0.02 14.0 0.0 0.03 13.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 CCF45655.1 - 0.047 13.0 0.0 0.087 12.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_26 PF13659.1 CCF45655.1 - 0.093 12.7 0.0 0.29 11.1 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Osteopontin PF00865.13 CCF45657.1 - 0.8 8.8 5.2 1.4 8.0 3.6 1.3 1 0 0 1 1 1 0 Osteopontin FAD_binding_4 PF01565.18 CCF45658.1 - 8.2e-28 96.6 0.7 1.3e-27 95.9 0.5 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_5 PF00941.16 CCF45658.1 - 0.074 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain in molybdopterin dehydrogenase Ribosomal_L3 PF00297.17 CCF45659.1 - 1.1e-116 388.8 7.3 1.4e-116 388.5 5.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 PCRF PF03462.13 CCF45662.1 - 2.5e-27 94.8 0.0 4e-27 94.2 0.0 1.3 1 0 0 1 1 1 1 PCRF domain GST_N_3 PF13417.1 CCF45663.1 - 9.1e-17 61.0 0.0 1e-16 60.8 0.0 1.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 CCF45663.1 - 6.2e-14 51.7 0.0 7.1e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 CCF45663.1 - 1.2e-12 47.8 0.0 1.3e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DAO PF01266.19 CCF45666.1 - 2.9e-09 36.2 0.0 3.1e-09 36.2 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase MFS_1 PF07690.11 CCF45667.1 - 2.9e-38 131.5 54.8 2.9e-38 131.5 38.0 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily ATP-synt_J PF04911.7 CCF45668.1 - 0.17 11.3 0.2 1 8.8 0.0 2.3 2 1 0 2 2 2 0 ATP synthase j chain Adipogenin PF15202.1 CCF45668.1 - 4.7 7.1 6.1 2.3 8.1 2.1 2.0 1 1 1 2 2 2 0 Adipogenin FAD_binding_4 PF01565.18 CCF45669.1 - 6.3e-20 71.0 4.2 1.3e-19 70.0 2.1 2.0 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.7 CCF45669.1 - 0.022 14.6 0.7 0.041 13.7 0.0 1.7 2 0 0 2 2 2 0 Berberine and berberine like RNA_pol_Rpb4 PF03874.11 CCF45671.1 - 8.7e-23 80.5 0.0 1e-22 80.3 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Ras PF00071.17 CCF45672.1 - 2e-13 50.0 0.0 2.3e-13 49.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Zn_clus PF00172.13 CCF45675.1 - 2.6e-10 40.0 8.4 4.6e-10 39.2 5.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF45675.1 - 0.0014 17.3 0.2 0.0018 16.9 0.2 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2182 PF09948.4 CCF45675.1 - 0.032 14.1 0.6 0.052 13.4 0.4 1.4 1 1 0 1 1 1 0 Predicted metal-binding integral membrane protein (DUF2182) Sugar_tr PF00083.19 CCF45677.1 - 4e-98 328.9 26.1 4.6e-98 328.7 18.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF45677.1 - 9.3e-35 119.9 48.8 1e-30 106.7 14.0 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.14 CCF45677.1 - 0.0009 17.9 0.4 0.0009 17.9 0.3 3.3 3 0 0 3 3 3 2 LacY proton/sugar symporter DUF3522 PF12036.3 CCF45677.1 - 0.0076 16.0 3.5 3 7.5 0.9 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF3522) SpoIIIAC PF06686.6 CCF45677.1 - 0.75 9.6 9.0 7 6.5 0.9 2.8 2 0 0 2 2 2 0 Stage III sporulation protein AC/AD protein family Herpes_LMP1 PF05297.6 CCF45677.1 - 3.5 6.4 15.4 0.052 12.4 5.1 1.9 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) L51_S25_CI-B8 PF05047.11 CCF45678.1 - 3.9e-16 58.5 0.1 6.4e-16 57.8 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain MMR_HSR1 PF01926.18 CCF45679.1 - 4.2e-05 23.4 0.0 0.00016 21.6 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase PPI_Ypi1 PF07491.6 CCF45680.1 - 1.1e-24 85.8 1.0 3.6e-24 84.1 0.7 2.0 1 1 0 1 1 1 1 Protein phosphatase inhibitor SR-25 PF10500.4 CCF45680.1 - 0.1 12.0 17.1 0.29 10.5 11.8 1.6 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein CDC45 PF02724.9 CCF45680.1 - 2.3 6.1 6.6 2.9 5.8 4.6 1.1 1 0 0 1 1 1 0 CDC45-like protein cobW PF02492.14 CCF45681.1 - 2.9e-34 118.0 0.0 3.7e-34 117.7 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 CCF45681.1 - 0.00012 20.9 0.4 0.0011 17.7 0.3 2.0 1 1 0 1 1 1 1 ArgK protein AAA_23 PF13476.1 CCF45681.1 - 0.0092 16.3 0.0 0.012 15.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 CCF45681.1 - 0.013 15.4 0.0 0.04 13.8 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase ResIII PF04851.10 CCF45681.1 - 0.016 15.0 0.0 0.02 14.7 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_11 PF13086.1 CCF45681.1 - 0.023 14.2 0.0 0.033 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 CCF45681.1 - 0.042 13.2 0.4 0.078 12.3 0.3 1.5 1 1 0 1 1 1 0 AAA domain CbiA PF01656.18 CCF45681.1 - 0.088 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_21 PF13304.1 CCF45681.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.4 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 CCF45681.1 - 0.11 13.2 0.6 0.25 12.1 0.4 1.6 1 1 0 1 1 1 0 AAA domain DUF663 PF04950.7 CCF45682.1 - 3e-101 338.3 0.0 4.2e-101 337.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 CCF45682.1 - 4.6e-19 67.7 0.0 1e-18 66.6 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain ATP-synt_F6 PF05511.6 CCF45683.1 - 0.048 13.5 0.6 0.094 12.6 0.4 1.5 1 0 0 1 1 1 0 Mitochondrial ATP synthase coupling factor 6 Pectinesterase PF01095.14 CCF45684.1 - 3.9e-46 156.9 8.7 4.9e-46 156.6 6.0 1.1 1 0 0 1 1 1 1 Pectinesterase DNA_ligase_A_N PF04675.9 CCF45685.1 - 1.3e-47 161.8 0.0 2.3e-47 161.0 0.0 1.3 1 0 0 1 1 1 1 DNA ligase N terminus KIAA1328 PF15369.1 CCF45685.1 - 0.23 11.2 14.2 0.32 10.7 9.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 DNA_mis_repair PF01119.14 CCF45687.1 - 1.3e-29 102.0 0.0 2.1e-29 101.4 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain Thioredoxin_8 PF13905.1 CCF45687.1 - 0.062 13.4 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like Gly_radical PF01228.16 CCF45688.1 - 0.055 13.8 0.0 0.088 13.1 0.0 1.2 1 0 0 1 1 1 0 Glycine radical CFEM PF05730.6 CCF45689.1 - 0.034 13.9 1.6 0.048 13.4 1.1 1.3 1 0 0 1 1 1 0 CFEM domain ABC_tran PF00005.22 CCF45692.1 - 9.8e-25 87.4 0.1 1.5e-24 86.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 CCF45692.1 - 0.0052 16.0 0.0 0.65 9.1 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain DUF87 PF01935.12 CCF45692.1 - 0.0062 16.3 0.1 0.0062 16.3 0.1 1.5 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_29 PF13555.1 CCF45692.1 - 0.0079 15.7 0.0 0.017 14.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.1 CCF45692.1 - 0.0098 15.8 0.1 0.18 11.7 0.1 2.1 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 CCF45692.1 - 0.017 14.2 0.0 0.028 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 SbcCD_C PF13558.1 CCF45692.1 - 0.029 14.2 0.0 0.055 13.3 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DEAD PF00270.24 CCF45692.1 - 0.03 13.8 0.3 0.46 9.9 0.2 2.1 1 1 0 1 1 1 0 DEAD/DEAH box helicase MMR_HSR1 PF01926.18 CCF45692.1 - 0.038 13.9 0.0 0.075 12.9 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.13 CCF45692.1 - 0.041 13.3 0.0 0.071 12.5 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Miro PF08477.8 CCF45692.1 - 0.071 13.6 0.1 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein AAA_16 PF13191.1 CCF45692.1 - 0.093 12.7 0.1 0.15 12.0 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.1 CCF45692.1 - 0.12 11.9 0.0 0.7 9.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.12 CCF45692.1 - 0.14 11.5 0.0 4.5 6.6 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF815 PF05673.8 CCF45692.1 - 0.17 10.7 0.0 0.3 9.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Abhydrolase_6 PF12697.2 CCF45693.1 - 7.3e-07 29.2 0.0 1.3e-06 28.4 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF45693.1 - 0.01 15.3 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold LCAT PF02450.10 CCF45693.1 - 0.041 12.8 0.0 0.066 12.1 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase PGAP1 PF07819.8 CCF45693.1 - 0.11 12.0 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.2 CCF45693.1 - 0.14 11.8 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF676 PF05057.9 CCF45693.1 - 0.18 11.0 0.0 0.45 9.7 0.0 1.6 2 0 0 2 2 2 0 Putative serine esterase (DUF676) RNA_pol_Rpc82 PF05645.8 CCF45694.1 - 2.8e-42 145.0 0.0 4.3e-42 144.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 Hormone_3 PF00159.13 CCF45695.1 - 0.5 10.4 3.3 14 5.7 0.1 3.7 2 0 0 2 2 2 0 Pancreatic hormone peptide HsbA PF12296.3 CCF45696.1 - 3.4e-17 62.4 13.2 3.4e-17 62.4 9.2 1.8 2 0 0 2 2 2 1 Hydrophobic surface binding protein A Antigen_Bd37 PF11641.3 CCF45696.1 - 0.035 13.3 0.3 0.043 13.0 0.2 1.1 1 0 0 1 1 1 0 Glycosylphosphatidylinositol-anchored merozoite surface protein YPEB PF14620.1 CCF45696.1 - 0.05 12.6 0.8 0.056 12.4 0.6 1.1 1 0 0 1 1 1 0 YpeB sporulation DUF4404 PF14357.1 CCF45696.1 - 0.089 13.2 1.2 0.38 11.1 0.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) ApoLp-III PF07464.6 CCF45696.1 - 0.18 11.8 6.8 0.25 11.3 3.2 2.0 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Sas10_Utp3 PF04000.10 CCF45696.1 - 0.23 11.6 4.2 0.4 10.8 0.4 2.6 3 0 0 3 3 3 0 Sas10/Utp3/C1D family NPV_P10 PF05531.7 CCF45696.1 - 0.4 10.9 12.2 1.1 9.5 0.2 3.1 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Ribosomal_60s PF00428.14 CCF45696.1 - 4.7 7.6 15.8 0.19 12.1 5.5 2.3 2 1 0 2 2 2 0 60s Acidic ribosomal protein Ctr PF04145.10 CCF45697.1 - 2.1e-34 118.6 12.2 2.4e-33 115.1 8.4 1.9 1 1 0 1 1 1 1 Ctr copper transporter family Ni_hydr_CYTB PF01292.15 CCF45697.1 - 0.00029 20.2 0.6 0.00035 20.0 0.4 1.1 1 0 0 1 1 1 1 Prokaryotic cytochrome b561 DUF1049 PF06305.6 CCF45697.1 - 0.11 11.9 1.3 2.9 7.4 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) Cytochrom_B_N PF00033.14 CCF45697.1 - 0.12 11.6 3.5 0.18 11.1 2.4 1.3 1 1 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB Papilloma_E5 PF03025.9 CCF45697.1 - 0.39 10.7 4.3 0.33 10.9 0.9 2.0 2 0 0 2 2 2 0 Papillomavirus E5 DUF4395 PF14340.1 CCF45697.1 - 1.2 9.2 6.8 4.4 7.3 4.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4395) Ribosomal_L4 PF00573.17 CCF45698.1 - 2.1e-13 50.0 0.0 2.6e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family DUF3604 PF12228.3 CCF45698.1 - 0.11 10.6 0.0 0.13 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3604) p450 PF00067.17 CCF45701.1 - 5e-41 140.6 0.0 5.6e-41 140.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Aldo_ket_red PF00248.16 CCF45702.1 - 1e-48 165.5 0.0 1.2e-48 165.3 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family AA_permease_2 PF13520.1 CCF45703.1 - 2.2e-55 187.9 33.8 2.7e-55 187.6 23.4 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF45703.1 - 2.9e-23 81.9 35.3 1.4e-22 79.7 17.6 2.2 2 0 0 2 2 2 2 Amino acid permease Saccharop_dh PF03435.13 CCF45704.1 - 2e-130 435.2 0.0 2.2e-130 435.0 0.0 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 CCF45704.1 - 7.8e-06 26.0 0.0 1.2e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 CCF45704.1 - 2.8e-05 24.2 0.3 4.3e-05 23.6 0.2 1.3 1 0 0 1 1 1 1 NADH(P)-binding IlvN PF07991.7 CCF45704.1 - 0.0018 17.6 0.2 0.027 13.8 0.0 2.7 2 1 0 2 2 2 1 Acetohydroxy acid isomeroreductase, catalytic domain GFO_IDH_MocA PF01408.17 CCF45704.1 - 0.016 15.7 0.0 0.059 13.8 0.0 1.9 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold GATA PF00320.22 CCF45705.1 - 1.1e-09 37.5 7.5 1.1e-09 37.5 5.2 1.9 2 0 0 2 2 2 1 GATA zinc finger GSu_C4xC__C2xCH PF09698.5 CCF45705.1 - 1.3 9.2 5.9 3.2 7.9 4.1 1.7 1 0 0 1 1 1 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) DUF106 PF01956.11 CCF45706.1 - 0.057 12.9 5.1 0.1 12.0 3.5 1.5 1 1 0 1 1 1 0 Integral membrane protein DUF106 PAT1 PF09770.4 CCF45706.1 - 0.092 10.9 60.3 0.11 10.7 41.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RP-C_C PF11800.3 CCF45706.1 - 0.16 11.6 9.8 0.25 11.0 6.8 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region Hid1 PF12722.2 CCF45706.1 - 0.25 8.9 16.2 0.29 8.7 11.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4638 PF15472.1 CCF45706.1 - 0.79 9.2 12.6 1.2 8.6 8.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Baculo_PP31 PF05311.6 CCF45706.1 - 1.2 8.3 9.5 1.9 7.7 6.6 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Zip PF02535.17 CCF45706.1 - 1.6 7.6 16.8 0.09 11.7 8.3 1.5 2 0 0 2 2 2 0 ZIP Zinc transporter Paramyxo_ncap PF00973.14 CCF45706.1 - 2.1 6.9 6.9 2.4 6.7 4.8 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein SeqA PF03925.8 CCF45706.1 - 3 7.5 12.2 5.5 6.6 8.5 1.3 1 0 0 1 1 1 0 SeqA protein Tim54 PF11711.3 CCF45706.1 - 4.6 5.7 12.9 6.3 5.2 8.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF3260 PF11658.3 CCF45706.1 - 4.6 5.2 15.1 7.5 4.5 10.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) DUF1631 PF07793.6 CCF45706.1 - 8.9 4.2 24.4 12 3.8 16.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) Oxysterol_BP PF01237.13 CCF45708.1 - 2.1e-86 289.6 0.0 2.7e-86 289.2 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein ILVD_EDD PF00920.16 CCF45709.1 - 2e-08 33.1 0.0 2.2e-08 32.9 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family ILVD_EDD PF00920.16 CCF45710.1 - 1.5e-40 139.1 0.0 1.6e-40 139.0 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family Herpes_U44 PF04533.8 CCF45710.1 - 0.023 13.9 0.0 0.028 13.6 0.0 1.0 1 0 0 1 1 1 0 Herpes virus U44 protein TPK_catalytic PF04263.11 CCF45711.1 - 8.1e-23 80.3 0.0 1.1e-22 79.8 0.0 1.1 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.9 CCF45711.1 - 6.9e-22 76.9 0.5 1.3e-21 76.0 0.3 1.5 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain V-SNARE_C PF12352.3 CCF45712.1 - 1.8e-15 56.7 0.2 2e-15 56.5 0.1 1.1 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 CCF45712.1 - 0.00013 21.5 0.0 0.00015 21.3 0.0 1.1 1 0 0 1 1 1 1 Sec20 Sigma70_r4 PF04545.11 CCF45712.1 - 0.0043 16.3 0.0 0.0065 15.7 0.0 1.3 1 0 0 1 1 1 1 Sigma-70, region 4 Zn_clus PF00172.13 CCF45713.1 - 0.042 13.7 14.8 0.066 13.1 10.3 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Cnd1_N PF12922.2 CCF45716.1 - 1.3e-56 190.9 0.1 2.1e-56 190.1 0.0 1.4 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term Ald_Xan_dh_C2 PF02738.13 CCF45716.1 - 0.0045 15.3 0.0 0.0064 14.8 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase Peptidase_C48 PF02902.14 CCF45719.1 - 1.8e-07 30.9 0.0 7.9e-07 28.9 0.0 1.9 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain zf-B_box PF00643.19 CCF45720.1 - 1.5e-05 24.7 3.8 2.4e-05 24.1 2.6 1.3 1 0 0 1 1 1 1 B-box zinc finger ketoacyl-synt PF00109.21 CCF45721.1 - 2.5e-74 249.9 0.1 2.9e-74 249.7 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.18 CCF45721.1 - 7.4e-06 25.1 0.0 1.2e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain MCR_beta_N PF02783.10 CCF45721.1 - 0.17 11.3 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, N-terminal domain Serglycin PF04360.7 CCF45722.1 - 0.07 12.8 0.3 0.13 11.9 0.2 1.5 1 0 0 1 1 1 0 Serglycin AAA_16 PF13191.1 CCF45723.1 - 8.6e-07 29.1 1.7 9.3e-05 22.4 0.4 2.9 2 1 0 2 2 2 1 AAA ATPase domain Arch_ATPase PF01637.13 CCF45723.1 - 1.3e-06 28.2 0.3 2.1e-06 27.6 0.2 1.3 1 0 0 1 1 1 1 Archaeal ATPase AAA_25 PF13481.1 CCF45723.1 - 0.041 13.2 0.5 0.44 9.9 0.0 2.7 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.8 CCF45723.1 - 0.042 12.7 0.0 0.087 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ATP-synt_ab PF00006.20 CCF45723.1 - 0.14 11.6 0.0 1.5 8.2 0.0 2.5 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain BNR PF02012.15 CCF45724.1 - 0.042 13.6 0.7 0.042 13.6 0.5 3.1 2 0 0 2 2 2 0 BNR/Asp-box repeat TEP1_N PF05386.6 CCF45725.1 - 0.14 11.6 0.1 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 TEP1 N-terminal domain DUF2667 PF10868.3 CCF45726.1 - 0.062 13.6 3.5 0.091 13.1 1.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2667) FXa_inhibition PF14670.1 CCF45726.1 - 0.16 12.1 6.1 0.13 12.3 2.9 2.0 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site EGF_2 PF07974.8 CCF45726.1 - 0.33 11.1 0.4 0.33 11.1 0.3 2.3 2 0 0 2 2 2 0 EGF-like domain DUF3433 PF11915.3 CCF45728.1 - 1.7e-15 56.9 3.5 1.7e-15 56.9 2.4 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3433) MFS_1 PF07690.11 CCF45729.1 - 1.4e-44 152.2 32.8 3.6e-44 150.9 22.7 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF45729.1 - 1.5e-11 43.5 12.6 1.5e-11 43.5 8.7 1.8 2 0 0 2 2 2 1 Sugar (and other) transporter DUF3754 PF12576.3 CCF45729.1 - 0.027 14.1 0.6 0.069 12.7 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3754) OATP PF03137.15 CCF45729.1 - 0.23 9.4 5.2 0.058 11.4 0.7 2.2 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family CorA PF01544.13 CCF45730.1 - 7.3e-06 25.2 10.6 0.00012 21.2 7.3 2.6 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Mnd1 PF03962.10 CCF45730.1 - 0.013 15.1 0.3 0.022 14.4 0.2 1.4 1 0 0 1 1 1 0 Mnd1 family Baculo_PEP_C PF04513.7 CCF45730.1 - 0.032 14.0 0.3 0.096 12.5 0.2 1.6 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Taxilin PF09728.4 CCF45730.1 - 0.033 13.2 0.1 0.058 12.4 0.1 1.3 1 0 0 1 1 1 0 Myosin-like coiled-coil protein Seryl_tRNA_N PF02403.17 CCF45730.1 - 0.057 13.4 1.4 0.13 12.2 0.3 2.0 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Pkinase PF00069.20 CCF45733.1 - 7.1e-17 61.4 0.0 2e-16 59.9 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF45733.1 - 4.2e-09 35.8 0.0 1.9e-08 33.7 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase MMR_HSR1_C PF08438.5 CCF45734.1 - 1.9e-32 111.7 0.0 3.8e-32 110.7 0.0 1.5 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.18 CCF45734.1 - 7.4e-06 25.9 0.0 1.8e-05 24.6 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase adh_short PF00106.20 CCF45735.1 - 1.9e-06 27.9 0.2 3.7e-06 26.9 0.1 1.5 1 1 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.12 CCF45735.1 - 0.0011 17.9 0.0 0.0019 17.1 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.16 CCF45735.1 - 0.0034 16.8 0.0 0.0058 16.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF45735.1 - 0.015 15.2 0.0 0.027 14.4 0.0 1.6 1 0 0 1 1 1 0 NADH(P)-binding 3HCDH_N PF02737.13 CCF45735.1 - 0.063 12.9 0.0 0.083 12.5 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IFRD PF05004.8 CCF45737.1 - 6.9e-25 87.7 0.6 9.5e-25 87.3 0.4 1.2 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) HEAT_EZ PF13513.1 CCF45737.1 - 6e-06 26.5 0.7 0.0023 18.3 0.0 3.7 2 1 2 4 4 4 1 HEAT-like repeat HEAT_2 PF13646.1 CCF45737.1 - 0.00036 20.7 0.7 0.037 14.2 0.1 2.7 1 1 2 3 3 3 2 HEAT repeats HEAT PF02985.17 CCF45737.1 - 0.0012 18.7 0.0 0.2 11.8 0.0 3.3 3 0 0 3 3 3 1 HEAT repeat FHA PF00498.21 CCF45738.1 - 5.3e-13 48.8 0.2 9.5e-13 48.0 0.1 1.5 1 0 0 1 1 1 1 FHA domain WD40 PF00400.27 CCF45739.1 - 1.1e-47 158.2 17.1 1.3e-11 43.8 0.0 7.4 8 0 0 8 8 8 6 WD domain, G-beta repeat Nup160 PF11715.3 CCF45739.1 - 8.5e-07 27.4 3.2 0.25 9.4 0.0 4.8 4 1 1 5 5 5 2 Nucleoporin Nup120/160 DUF3312 PF11768.3 CCF45739.1 - 0.0014 16.9 0.0 0.0032 15.7 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3312) Coatomer_WDAD PF04053.9 CCF45739.1 - 0.0016 17.2 0.0 0.0021 16.9 0.0 1.2 1 0 0 1 1 1 1 Coatomer WD associated region Nucleoporin_N PF08801.6 CCF45739.1 - 0.037 12.7 0.4 1.4 7.5 0.1 3.2 1 1 1 2 2 1 0 Nup133 N terminal like HPS3_N PF14761.1 CCF45739.1 - 0.057 12.8 0.0 0.39 10.0 0.0 2.1 2 1 0 2 2 2 0 Hermansky-Pudlak syndrome 3 SUKH_5 PF14567.1 CCF45739.1 - 0.11 11.9 0.6 5.8 6.3 0.1 3.2 2 1 1 3 3 3 0 SMI1-KNR4 cell-wall HEAT PF02985.17 CCF45740.1 - 8.7e-12 44.0 3.3 0.049 13.7 0.0 5.9 5 1 1 6 6 6 3 HEAT repeat Pkinase PF00069.20 CCF45740.1 - 1.2e-08 34.4 0.0 2.1e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF45740.1 - 5.2e-05 22.4 0.0 0.0001 21.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT_EZ PF13513.1 CCF45740.1 - 8.1e-05 22.9 0.0 2.1 8.9 0.0 3.8 2 1 1 3 3 3 2 HEAT-like repeat HEAT_2 PF13646.1 CCF45740.1 - 8.3e-05 22.7 0.0 0.05 13.8 0.0 3.1 1 1 2 3 3 3 2 HEAT repeats Cnd1 PF12717.2 CCF45740.1 - 0.031 14.1 0.0 0.077 12.8 0.0 1.8 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.15 CCF45740.1 - 0.053 11.8 0.1 0.2 9.9 0.1 1.6 1 1 1 2 2 2 0 Adaptin N terminal region Vac14_Fab1_bd PF12755.2 CCF45740.1 - 0.14 12.5 0.2 3 8.2 0.0 2.7 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region DUF3554 PF12074.3 CCF45740.1 - 0.17 11.2 0.0 0.33 10.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3554) Peptidase_S8 PF00082.17 CCF45741.1 - 3.1e-17 62.6 0.0 4.7e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 Subtilase family UEV PF05743.8 CCF45742.1 - 2.8e-37 127.0 0.0 4.4e-37 126.4 0.0 1.3 1 0 0 1 1 1 1 UEV domain UQ_con PF00179.21 CCF45742.1 - 0.00069 19.0 0.1 0.001 18.5 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RSN1_TM PF13967.1 CCF45744.1 - 3.1e-30 104.7 1.4 3.8e-30 104.5 1.0 1.0 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport PepSY_TM_2 PF13703.1 CCF45744.1 - 0.2 11.8 1.3 18 5.5 0.0 2.3 2 1 0 2 2 2 0 PepSY-associated TM helix Transp_cyt_pur PF02133.10 CCF45745.1 - 7.5e-43 146.6 36.2 9.4e-43 146.3 25.1 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF925 PF06042.6 CCF45746.1 - 2.3e-32 111.7 0.0 7.8e-18 64.5 0.0 2.1 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF925) AP_endonuc_2 PF01261.19 CCF45747.1 - 9.5e-33 113.2 0.0 1.3e-32 112.7 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel 2OG-FeII_Oxy_3 PF13640.1 CCF45748.1 - 2.1e-09 37.7 0.0 4.2e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 CCF45748.1 - 4.1e-07 29.5 0.0 2.3e-06 27.1 0.0 2.1 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Ribosomal_L6 PF00347.18 CCF45749.1 - 4.9e-24 84.6 6.2 3.7e-11 43.3 0.1 2.2 2 0 0 2 2 2 2 Ribosomal protein L6 RCR PF12273.3 CCF45750.1 - 6.1e-15 55.9 10.6 1.6e-14 54.5 7.3 1.7 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red Adeno_E3_CR2 PF02439.10 CCF45750.1 - 0.01 15.3 0.7 0.023 14.2 0.5 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Shisa PF13908.1 CCF45750.1 - 0.031 14.4 0.0 0.046 13.8 0.0 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF2668 PF10873.3 CCF45750.1 - 0.11 12.6 0.2 0.2 11.8 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2668) DUF1191 PF06697.7 CCF45750.1 - 0.14 10.9 0.1 0.2 10.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) WBP-1 PF11669.3 CCF45750.1 - 0.72 9.9 4.4 1.6 8.8 3.1 1.7 1 1 0 1 1 1 0 WW domain-binding protein 1 Glyco_hydro_31 PF01055.21 CCF45751.1 - 6.1e-98 328.5 4.3 6.1e-97 325.2 3.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 Aa_trans PF01490.13 CCF45752.1 - 1.7e-41 142.1 35.3 1.8e-41 141.9 24.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ATG27 PF09451.5 CCF45752.1 - 0.025 13.8 1.6 0.047 12.9 1.1 1.4 1 0 0 1 1 1 0 Autophagy-related protein 27 Bac_luciferase PF00296.15 CCF45753.1 - 1.4e-20 73.6 0.2 1.5e-20 73.5 0.1 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase Bac_luciferase PF00296.15 CCF45754.1 - 0.0043 16.2 0.0 0.0048 16.0 0.0 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase Oxidored_molyb PF00174.14 CCF45755.1 - 1.6e-45 154.5 0.0 4.8e-45 152.9 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.11 CCF45755.1 - 7.2e-24 83.8 3.1 1.2e-23 83.2 2.1 1.3 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Acyl_transf_1 PF00698.16 CCF45756.1 - 6.9e-15 55.1 0.0 2.1e-10 40.4 0.0 2.2 2 0 0 2 2 2 2 Acyl transferase domain DUF1908 PF08926.6 CCF45759.1 - 0.13 11.0 2.6 0.14 10.9 1.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1908) CLU PF13236.1 CCF45763.1 - 6.3e-81 271.0 0.0 1.1e-80 270.1 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.2 CCF45763.1 - 2.2e-50 170.8 0.4 6e-50 169.4 0.0 1.9 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.1 CCF45763.1 - 1.4e-25 89.2 0.1 2.9e-25 88.1 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_12 PF13424.1 CCF45763.1 - 3.7e-20 71.6 9.2 3.8e-09 36.3 0.1 3.8 2 1 1 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.1 CCF45763.1 - 1.4e-15 56.6 0.1 0.0011 18.7 0.0 4.4 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_11 PF13414.1 CCF45763.1 - 1.3e-05 24.7 5.4 0.022 14.4 0.4 3.6 3 0 0 3 3 3 2 TPR repeat TPR_2 PF07719.12 CCF45763.1 - 0.00014 21.4 3.7 0.029 14.2 0.1 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat CDC45 PF02724.9 CCF45763.1 - 0.035 12.1 12.0 0.055 11.5 8.3 1.2 1 0 0 1 1 1 0 CDC45-like protein TPR_8 PF13181.1 CCF45763.1 - 0.13 12.0 4.6 0.37 10.6 0.4 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DDHD PF02862.12 CCF45763.1 - 1.6 8.5 7.8 3.8 7.2 5.4 1.6 1 0 0 1 1 1 0 DDHD domain Na_trans_assoc PF06512.8 CCF45763.1 - 4.2 7.2 15.2 8.7 6.2 10.6 1.5 1 0 0 1 1 1 0 Sodium ion transport-associated Fork_head PF00250.13 CCF45764.1 - 1.7e-34 117.7 0.2 3.2e-34 116.8 0.1 1.4 1 0 0 1 1 1 1 Fork head domain FHA PF00498.21 CCF45764.1 - 8.1e-09 35.4 0.0 1.8e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 FHA domain BOP1NT PF08145.7 CCF45765.1 - 4.6e-47 160.9 11.7 7.9e-47 160.1 8.1 1.4 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.27 CCF45765.1 - 1.5e-29 100.7 4.9 6.2e-13 48.0 0.1 6.3 6 1 0 6 6 6 4 WD domain, G-beta repeat Apc4_WD40 PF12894.2 CCF45765.1 - 0.1 12.1 0.0 18 4.9 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Anticodon_1 PF08264.8 CCF45767.1 - 3.7e-27 94.9 0.0 1.7e-26 92.8 0.0 2.0 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA Peptidase_M61 PF05299.7 CCF45769.1 - 0.084 12.8 0.1 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 M61 glycyl aminopeptidase Amidohydro_3 PF07969.6 CCF45771.1 - 2.5e-24 86.2 0.1 3.8e-24 85.6 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 CCF45771.1 - 6.6e-10 38.6 0.1 4.8e-09 35.9 0.0 2.3 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_4 PF13147.1 CCF45771.1 - 4.9e-05 23.4 1.0 0.00029 20.9 0.7 2.1 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 CCF45771.1 - 0.013 15.1 0.0 0.037 13.6 0.0 1.8 2 0 0 2 2 2 0 Amidohydrolase family Glyco_hydro_7 PF00840.15 CCF45772.1 - 2.5e-180 599.4 25.2 2.8e-180 599.3 17.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 Colipase-like PF15083.1 CCF45772.1 - 0.032 14.1 0.2 0.096 12.6 0.2 1.8 1 0 0 1 1 1 0 Colipase-like Bromodomain PF00439.20 CCF45773.1 - 5e-18 64.8 0.0 9.7e-18 63.8 0.0 1.6 1 0 0 1 1 1 1 Bromodomain CHCH PF06747.8 CCF45773.1 - 0.032 14.1 1.9 1.5 8.8 0.0 2.4 2 0 0 2 2 2 0 CHCH domain Aa_trans PF01490.13 CCF45776.1 - 4.9e-15 54.9 0.6 5e-15 54.9 0.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF1056 PF06341.6 CCF45776.1 - 0.031 14.3 0.2 0.068 13.2 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1056) Phage_CII PF05269.6 CCF45776.1 - 0.13 12.3 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage CII protein RNA_pol_L_2 PF13656.1 CCF45777.1 - 6.4e-24 83.1 0.2 7.9e-24 82.8 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 CCF45777.1 - 3.5e-09 35.6 0.0 5e-09 35.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Cep57_MT_bd PF06657.8 CCF45777.1 - 0.035 14.0 0.5 0.06 13.3 0.1 1.6 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 SseB_C PF14581.1 CCF45777.1 - 0.082 12.7 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 SseB protein C-terminal domain SIR2_2 PF13289.1 CCF45777.1 - 0.099 12.5 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 SIR2-like domain LSM PF01423.17 CCF45778.1 - 3.5e-21 74.5 0.0 3.9e-21 74.3 0.0 1.0 1 0 0 1 1 1 1 LSM domain DNA_pol_A_exo1 PF01612.15 CCF45779.1 - 1.1e-18 67.2 0.0 1.6e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease NAD_binding_2 PF03446.10 CCF45780.1 - 4.6e-05 23.3 0.0 5.6e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 CCF45780.1 - 0.0002 21.7 0.1 0.00027 21.2 0.1 1.2 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.13 CCF45780.1 - 0.0058 16.2 0.1 0.0092 15.6 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sulfate_tra_GLY PF13792.1 CCF45781.1 - 6.3e-31 105.8 2.8 6.3e-31 105.8 1.9 2.0 2 0 0 2 2 2 1 Sulfate transporter N-terminal domain with GLY motif Sulfate_transp PF00916.15 CCF45781.1 - 5.1e-12 45.3 0.3 9.4e-12 44.5 0.0 1.5 2 0 0 2 2 2 1 Sulfate transporter family Methyltransf_23 PF13489.1 CCF45782.1 - 4.9e-15 55.5 0.0 7.7e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF45782.1 - 2e-06 28.3 0.0 2e-05 25.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF45782.1 - 0.00016 21.2 0.0 0.0008 19.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF45782.1 - 0.00018 21.9 0.0 0.00036 20.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain CheR PF01739.13 CCF45782.1 - 0.00055 19.2 0.0 0.0009 18.5 0.0 1.2 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_12 PF08242.7 CCF45782.1 - 0.0008 19.8 0.0 0.0052 17.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain DDE_1 PF03184.14 CCF45783.1 - 5.4e-30 104.1 0.0 6.9e-30 103.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.11 CCF45783.1 - 3.3e-12 45.7 0.1 6e-12 44.9 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF45783.1 - 1.1e-07 31.5 0.4 3.7e-07 29.8 0.0 2.2 2 1 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.1 CCF45783.1 - 0.037 13.7 0.0 0.056 13.1 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease DDE_1 PF03184.14 CCF45784.1 - 9.6e-42 142.5 0.0 1.3e-41 142.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.11 CCF45784.1 - 2.8e-12 45.9 0.1 6.5e-12 44.7 0.1 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF45784.1 - 1.8e-05 24.4 0.0 4.6e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_24 PF13412.1 CCF45784.1 - 0.057 12.8 0.1 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_23 PF13384.1 CCF45784.1 - 0.085 12.5 0.0 0.22 11.2 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain DUF3620 PF12281.3 CCF45786.1 - 0.079 12.6 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3620) NUC202 PF08166.7 CCF45787.1 - 0.072 12.9 0.1 0.08 12.8 0.0 1.2 1 0 0 1 1 1 0 NUC202 domain SecM PF06558.7 CCF45787.1 - 0.1 12.3 0.0 0.11 12.1 0.0 1.1 1 0 0 1 1 1 0 Secretion monitor precursor protein (SecM) CVNH PF08881.5 CCF45789.1 - 1.4e-14 54.1 0.1 2e-14 53.6 0.1 1.2 1 0 0 1 1 1 1 CVNH domain PAS_9 PF13426.1 CCF45790.1 - 1.3e-15 57.6 0.0 5.5e-15 55.6 0.0 2.1 2 0 0 2 2 2 1 PAS domain RGS PF00615.14 CCF45790.1 - 7.7e-09 35.6 0.3 2.1e-08 34.2 0.2 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain PAS PF00989.19 CCF45790.1 - 0.03 14.0 0.0 0.084 12.6 0.0 1.7 1 0 0 1 1 1 0 PAS fold Glyco_hydro_61 PF03443.9 CCF45791.1 - 0.014 15.2 0.1 0.068 12.9 0.0 1.8 2 0 0 2 2 2 0 Glycosyl hydrolase family 61 DUF4493 PF14900.1 CCF45791.1 - 0.054 13.1 0.5 0.11 12.1 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4493) Wzt_C PF14524.1 CCF45791.1 - 0.094 12.4 0.0 0.17 11.5 0.0 1.6 1 1 0 1 1 1 0 Wzt C-terminal domain NPCBM_assoc PF10633.4 CCF45791.1 - 0.13 12.3 1.2 0.74 9.9 0.0 2.5 3 0 0 3 3 3 0 NPCBM-associated, NEW3 domain of alpha-galactosidase CDC45 PF02724.9 CCF45794.1 - 0.00019 19.6 11.3 0.0002 19.5 7.8 1.2 1 0 0 1 1 1 1 CDC45-like protein SAPS PF04499.10 CCF45794.1 - 0.03 12.9 8.2 0.039 12.6 5.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Nop14 PF04147.7 CCF45794.1 - 0.074 10.9 30.6 0.092 10.6 21.2 1.1 1 0 0 1 1 1 0 Nop14-like family Daxx PF03344.10 CCF45794.1 - 0.086 11.3 23.1 0.11 10.9 16.0 1.1 1 0 0 1 1 1 0 Daxx Family DUF2890 PF11081.3 CCF45794.1 - 0.096 12.7 6.4 0.12 12.3 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) BTV_NS2 PF04514.7 CCF45794.1 - 0.69 8.7 10.4 0.95 8.2 7.2 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 DUF2457 PF10446.4 CCF45794.1 - 0.77 8.4 39.7 1.6 7.3 27.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF1510 PF07423.6 CCF45794.1 - 0.78 9.0 23.0 1.1 8.5 15.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Ycf1 PF05758.7 CCF45794.1 - 1.1 6.8 2.9 1.2 6.7 2.0 1.2 1 0 0 1 1 1 0 Ycf1 SDA1 PF05285.7 CCF45794.1 - 1.4 8.1 27.2 1.9 7.7 18.9 1.1 1 0 0 1 1 1 0 SDA1 CENP-T PF15511.1 CCF45794.1 - 2 7.6 19.2 2.8 7.1 13.3 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Tim54 PF11711.3 CCF45794.1 - 2 6.8 7.8 2.8 6.4 5.4 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2146 PF10220.4 CCF45794.1 - 2.1 6.2 10.8 2.6 5.9 7.5 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) Sporozoite_P67 PF05642.6 CCF45794.1 - 2.7 5.7 18.3 5 4.8 12.6 1.4 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Hid1 PF12722.2 CCF45794.1 - 7.4 4.1 13.3 9.2 3.7 9.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TRAP_alpha PF03896.11 CCF45794.1 - 7.7 5.4 15.5 11 4.8 10.8 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit NPR3 PF03666.8 CCF45794.1 - 9.3 4.6 13.4 12 4.2 9.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 BUD22 PF09073.5 CCF45794.1 - 9.3 5.1 25.7 12 4.8 17.8 1.1 1 0 0 1 1 1 0 BUD22 Herpes_U26 PF07402.6 CCF45796.1 - 0.3 10.3 8.5 0.57 9.4 5.9 1.6 1 1 0 1 1 1 0 Human herpesvirus U26 protein AhpC-TSA PF00578.16 CCF45797.1 - 1.6e-32 111.7 0.0 2.1e-32 111.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 CCF45797.1 - 2.7e-13 49.7 0.0 3.6e-13 49.2 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 CCF45797.1 - 7.2e-12 44.7 0.1 1.5e-11 43.7 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Ribosomal_L23eN PF03939.8 CCF45798.1 - 1.3e-17 63.5 7.6 1.3e-17 63.5 5.3 2.2 2 1 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.15 CCF45798.1 - 1.6e-16 60.0 1.7 3.3e-16 58.9 1.2 1.6 1 0 0 1 1 1 1 Ribosomal protein L23 zf-Tim10_DDP PF02953.10 CCF45799.1 - 1.1e-18 66.2 1.5 1.3e-18 66.0 1.1 1.0 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Pkinase PF00069.20 CCF45801.1 - 1.3e-61 207.9 0.0 1.9e-61 207.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF45801.1 - 1.2e-32 113.0 0.0 1.6e-31 109.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF45801.1 - 4.1e-05 22.7 0.2 0.0021 17.0 0.0 2.6 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 CCF45801.1 - 0.00046 19.3 0.0 0.00076 18.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CCF45801.1 - 0.0021 17.8 0.2 0.0082 15.8 0.1 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 CCF45801.1 - 0.2 10.4 1.0 3.9 6.1 0.1 2.0 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase Aldedh PF00171.17 CCF45802.1 - 9.1e-39 133.0 2.7 1.8e-16 59.5 0.1 3.0 1 1 2 3 3 3 3 Aldehyde dehydrogenase family TAXi_C PF14541.1 CCF45802.1 - 0.12 11.8 0.1 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal zf-C2H2 PF00096.21 CCF45803.1 - 0.059 13.7 0.5 0.18 12.2 0.3 1.9 1 1 0 1 1 1 0 Zinc finger, C2H2 type DEK_C PF08766.6 CCF45804.1 - 7.7e-12 44.8 0.2 5e-11 42.2 0.4 1.9 2 0 0 2 2 2 1 DEK C terminal domain GFA PF04828.9 CCF45806.1 - 2.8e-12 46.3 0.1 5.4e-12 45.4 0.1 1.5 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Ferric_reduct PF01794.14 CCF45807.1 - 7.2e-17 61.6 16.8 7.2e-17 61.6 11.7 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 CCF45807.1 - 6.2e-11 42.1 0.0 6.2e-06 26.0 0.0 2.4 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_6 PF08030.7 CCF45807.1 - 2.9e-08 33.7 0.0 4.6e-07 29.8 0.0 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Pam17 PF08566.5 CCF45808.1 - 7.8e-66 221.0 0.0 1.2e-65 220.4 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 Med3 PF11593.3 CCF45808.1 - 0.02 14.1 0.8 0.021 14.0 0.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF3040 PF11239.3 CCF45808.1 - 0.1 12.6 0.2 0.24 11.4 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Rho_GDI PF02115.12 CCF45810.1 - 1.9e-27 95.9 5.2 3e-27 95.3 0.5 2.0 2 0 0 2 2 2 1 RHO protein GDP dissociation inhibitor Daxx PF03344.10 CCF45810.1 - 0.003 16.1 1.8 0.0028 16.2 1.3 1.0 1 0 0 1 1 1 1 Daxx Family PHD_3 PF13922.1 CCF45810.1 - 3.9 7.7 6.7 8.1 6.7 4.6 1.5 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx DUF3248 PF11609.3 CCF45811.1 - 0.057 13.1 0.1 0.07 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3248) DUF1162 PF06650.7 CCF45813.1 - 2.3e-88 296.0 0.0 5.2e-88 294.8 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1162) p450 PF00067.17 CCF45815.1 - 4.2e-58 196.9 0.0 9.7e-56 189.1 0.0 2.9 2 1 0 2 2 2 2 Cytochrome P450 DUF1219 PF06755.7 CCF45815.1 - 0.0053 16.2 0.0 0.013 15.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1219) p450 PF00067.17 CCF45816.1 - 7e-50 169.8 0.0 9.3e-50 169.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FTR1 PF03239.9 CCF45818.1 - 6.9e-57 192.7 7.1 7.8e-57 192.5 4.9 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Tmemb_14 PF03647.8 CCF45818.1 - 0.05 14.0 1.2 0.05 14.0 0.9 2.7 2 1 0 2 2 2 0 Transmembrane proteins 14C Na_Ca_ex PF01699.19 CCF45818.1 - 2.1 7.9 12.0 1.8 8.1 2.5 2.5 2 1 0 2 2 2 0 Sodium/calcium exchanger protein Bax1-I PF01027.15 CCF45818.1 - 3.1 7.3 14.9 0.32 10.5 4.8 2.2 1 1 1 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 DUF4307 PF14155.1 CCF45818.1 - 4.6 7.0 5.5 2.4 7.9 0.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4307) Glyco_hydro_15 PF00723.16 CCF45821.1 - 0.00014 20.5 0.1 0.00017 20.3 0.0 1.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 Bromo_TP PF07524.8 CCF45822.1 - 2.3e-08 33.6 0.0 4.1e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated Dynamin_N PF00350.18 CCF45824.1 - 2.8e-05 24.0 0.8 0.00023 21.0 0.0 2.4 2 1 0 2 2 2 1 Dynamin family Pro_dh PF01619.13 CCF45824.1 - 0.011 14.7 1.8 0.019 13.9 1.3 1.4 1 0 0 1 1 1 0 Proline dehydrogenase DivIC PF04977.10 CCF45824.1 - 0.065 12.7 4.4 0.41 10.1 0.2 2.8 2 0 0 2 2 2 0 Septum formation initiator DUF904 PF06005.7 CCF45824.1 - 0.083 13.1 0.1 0.083 13.1 0.1 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF904) IncA PF04156.9 CCF45824.1 - 0.11 12.1 12.7 4.4 6.8 8.8 2.5 1 1 0 1 1 1 0 IncA protein DUF972 PF06156.8 CCF45824.1 - 3 8.2 9.2 3.7 7.9 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF972) DUF848 PF05852.6 CCF45824.1 - 6.5 6.6 11.1 1.2 9.0 0.3 2.7 2 1 0 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) SMP PF04927.7 CCF45826.1 - 3.1e-16 59.0 14.0 2.2e-10 40.3 4.9 2.1 1 1 1 2 2 2 2 Seed maturation protein p450 PF00067.17 CCF45829.1 - 3.2e-25 88.5 0.0 1.2e-24 86.6 0.0 1.9 2 0 0 2 2 2 1 Cytochrome P450 CorA PF01544.13 CCF45831.1 - 0.0018 17.4 2.8 0.0049 15.9 2.0 1.7 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF4532 PF15046.1 CCF45831.1 - 0.032 13.2 0.3 0.074 12.0 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4532) HAUS-augmin3 PF14932.1 CCF45831.1 - 0.056 12.6 1.6 0.098 11.8 1.1 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 GPI-anchored PF10342.4 CCF45832.1 - 1.8e-17 63.5 4.0 1.8e-17 63.5 2.8 2.3 2 1 1 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family GATase_6 PF13522.1 CCF45834.1 - 9.6e-36 122.6 0.0 1.5e-35 122.0 0.0 1.3 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_7 PF13537.1 CCF45834.1 - 2.1e-35 121.1 0.0 3.1e-35 120.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_2 PF00310.16 CCF45834.1 - 4.1e-05 22.4 0.0 1.1 7.9 0.0 3.0 1 1 2 3 3 3 3 Glutamine amidotransferases class-II DUF3700 PF12481.3 CCF45834.1 - 6.3e-05 22.2 0.0 8.6e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Aluminium induced protein E1-E2_ATPase PF00122.15 CCF45835.1 - 7e-64 215.0 3.1 1e-63 214.4 2.2 1.2 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_N PF00690.21 CCF45835.1 - 6e-16 57.6 0.1 2.1e-15 55.9 0.0 1.9 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.21 CCF45835.1 - 0.0008 19.8 0.1 0.0027 18.1 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2207 PF09972.4 CCF45835.1 - 0.18 10.3 0.3 0.32 9.5 0.2 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ank_2 PF12796.2 CCF45836.1 - 2.1e-36 124.1 3.6 3.4e-18 65.7 0.1 5.3 3 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 CCF45836.1 - 3.3e-31 105.5 0.1 2.7e-06 26.9 0.0 8.7 9 1 0 9 9 9 4 Ankyrin repeat Ank_3 PF13606.1 CCF45836.1 - 6.5e-23 78.5 1.3 0.003 17.6 0.0 9.8 10 0 0 10 10 10 6 Ankyrin repeat Ank_4 PF13637.1 CCF45836.1 - 5.5e-22 77.7 1.3 1.7e-09 37.8 0.0 7.0 5 1 2 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF45836.1 - 1.9e-21 75.5 2.7 2e-08 34.2 0.1 8.4 7 2 3 10 10 10 5 Ankyrin repeats (many copies) MFS_1 PF07690.11 CCF45837.1 - 4.5e-34 117.7 21.7 4.5e-34 117.7 15.0 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF1446 PF07287.6 CCF45839.1 - 1.1e-54 185.2 0.0 1.4e-54 184.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1446) MaoC_dehydrat_N PF13452.1 CCF45840.1 - 0.00066 19.4 0.0 0.0008 19.1 0.0 1.2 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase Abhydrolase_4 PF08386.5 CCF45841.1 - 6e-16 58.2 0.0 6.3e-14 51.7 0.0 2.3 2 0 0 2 2 2 1 TAP-like protein Abhydrolase_1 PF00561.15 CCF45841.1 - 3.7e-14 52.8 0.1 5.3e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF45841.1 - 2.1e-10 40.8 0.0 8.6e-10 38.8 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF45841.1 - 0.00017 21.3 0.0 0.0027 17.4 0.0 2.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Zn_clus PF00172.13 CCF45842.1 - 2e-06 27.6 8.7 5.2e-06 26.2 6.0 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF45842.1 - 0.00023 19.8 0.1 0.00058 18.5 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sugar_tr PF00083.19 CCF45843.1 - 1.8e-115 386.1 25.8 2.9e-115 385.4 17.9 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF45843.1 - 2e-29 102.4 62.3 1.3e-24 86.5 21.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily AA_permease_2 PF13520.1 CCF45844.1 - 1.2e-19 70.1 29.4 1.4e-19 69.9 20.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF45844.1 - 5.2e-15 54.7 27.0 6e-15 54.5 18.7 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4350 PF14258.1 CCF45845.1 - 0.0037 17.4 0.1 1.3 9.2 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4350) MFS_1 PF07690.11 CCF45848.1 - 9.1e-06 24.6 0.0 9.4e-06 24.5 0.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.8 CCF45848.1 - 0.0024 17.1 0.1 0.0029 16.9 0.1 1.1 1 0 0 1 1 1 1 Nodulin-like HpaP PF09483.5 CCF45848.1 - 0.0044 16.9 0.5 0.0055 16.6 0.4 1.1 1 0 0 1 1 1 1 Type III secretion protein (HpaP) ATPase_gene1 PF09527.5 CCF45848.1 - 0.19 11.5 3.8 0.16 11.8 0.7 2.0 1 1 1 2 2 2 0 Putative F0F1-ATPase subunit (ATPase_gene1) MAPEG PF01124.13 CCF45850.1 - 0.00056 19.5 3.0 0.0014 18.2 2.1 1.7 1 1 0 1 1 1 1 MAPEG family DUF202 PF02656.10 CCF45850.1 - 4.5 7.5 8.4 40 4.5 5.8 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF202) UNC-93 PF05978.11 CCF45851.1 - 1.2e-07 31.3 7.4 1.5e-07 31.0 5.1 1.3 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.11 CCF45851.1 - 3.8e-07 29.1 12.4 7.4e-07 28.2 8.5 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF45851.1 - 0.053 12.0 8.6 0.06 11.9 6.0 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter MFS_1 PF07690.11 CCF45852.1 - 0.059 12.0 9.6 0.18 10.4 6.7 1.6 1 1 0 1 1 1 0 Major Facilitator Superfamily DUF1469 PF07332.6 CCF45852.1 - 0.067 12.9 0.1 0.38 10.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) DUF2566 PF10753.4 CCF45852.1 - 1.1 9.1 8.3 0.39 10.6 0.5 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2566) Pyr_redox_3 PF13738.1 CCF45853.1 - 4.3e-22 79.1 0.1 1.1e-21 77.7 0.1 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 CCF45853.1 - 2.6e-12 45.7 0.0 2.1e-10 39.4 0.0 2.1 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 CCF45853.1 - 6e-12 45.4 1.4 4.4e-09 36.2 0.2 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF45853.1 - 2.7e-11 43.7 0.1 4.7e-06 26.6 0.0 3.2 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CCF45853.1 - 4e-09 35.8 0.1 1.1e-06 27.7 0.0 2.5 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.19 CCF45853.1 - 2.5e-08 33.2 0.9 0.087 11.7 0.0 4.1 4 0 0 4 4 4 3 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 CCF45853.1 - 0.00022 21.0 3.9 1.3 8.7 0.4 4.0 3 1 0 3 3 3 2 FAD-NAD(P)-binding Pyr_redox PF00070.22 CCF45853.1 - 0.001 19.4 3.0 0.92 9.9 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF45853.1 - 0.0016 17.5 1.4 0.59 9.1 0.1 2.4 2 0 0 2 2 2 2 Thi4 family FAD_binding_2 PF00890.19 CCF45853.1 - 0.0019 17.0 0.1 0.0019 17.0 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain Shikimate_DH PF01488.15 CCF45853.1 - 0.0039 17.2 0.1 0.15 12.1 0.0 2.5 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 CCF45853.1 - 0.0039 17.4 0.0 0.98 9.7 0.0 2.8 3 0 0 3 3 2 1 Putative NAD(P)-binding FAD_binding_3 PF01494.14 CCF45853.1 - 0.0053 15.8 0.6 0.12 11.4 0.1 2.6 3 0 0 3 3 3 1 FAD binding domain ThiF PF00899.16 CCF45853.1 - 0.065 13.0 3.1 9.8 6.0 0.1 3.6 4 0 0 4 4 4 0 ThiF family 2-Hacid_dh_C PF02826.14 CCF45853.1 - 0.078 12.1 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Lycopene_cycl PF05834.7 CCF45853.1 - 0.15 10.9 1.9 1 8.1 0.1 2.5 2 1 0 2 2 2 0 Lycopene cyclase protein GIDA PF01134.17 CCF45853.1 - 0.37 9.5 5.8 6.3 5.5 0.0 3.4 4 0 0 4 4 4 0 Glucose inhibited division protein A FAD_oxidored PF12831.2 CCF45853.1 - 0.42 9.6 5.7 0.38 9.7 1.7 2.4 2 1 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.9 CCF45853.1 - 0.46 8.8 4.6 4.6 5.5 0.1 2.6 3 0 0 3 3 3 0 HI0933-like protein p450 PF00067.17 CCF45854.1 - 4.4e-30 104.6 0.0 5.7e-30 104.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ADH_N PF08240.7 CCF45855.1 - 8.9e-09 35.0 0.0 1.4e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF45855.1 - 1e-06 28.3 0.0 2.1e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Pec_lyase_C PF00544.14 CCF45856.1 - 2.8e-45 154.2 4.9 3.9e-45 153.7 3.4 1.2 1 0 0 1 1 1 1 Pectate lyase Zn_clus PF00172.13 CCF45859.1 - 1e-07 31.7 6.5 2e-07 30.8 4.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TIP49 PF06068.8 CCF45860.1 - 4.5e-175 582.1 4.2 5.3e-175 581.8 2.9 1.0 1 0 0 1 1 1 1 TIP49 C-terminus RuvB_N PF05496.7 CCF45860.1 - 5.5e-09 35.4 3.1 2e-05 23.7 0.0 3.1 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA PF00004.24 CCF45860.1 - 1.9e-08 34.5 0.9 3.3e-05 24.1 0.0 3.3 2 1 1 3 3 3 2 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.10 CCF45860.1 - 2.9e-06 26.3 0.4 4.9e-06 25.6 0.3 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_22 PF13401.1 CCF45860.1 - 0.00018 21.6 0.0 0.17 12.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 CCF45860.1 - 0.00029 20.8 0.0 0.0027 17.7 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.16 CCF45860.1 - 0.00099 18.3 0.8 0.019 14.1 0.2 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.1 CCF45860.1 - 0.0014 18.5 0.0 1.5 8.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.21 CCF45860.1 - 0.0064 15.9 0.0 2.2 7.7 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_5 PF07728.9 CCF45860.1 - 0.018 14.7 0.1 2.9 7.6 0.0 2.8 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 CCF45860.1 - 0.023 14.4 0.4 0.089 12.5 0.3 2.0 1 1 0 1 1 1 0 Part of AAA domain Parvo_NS1 PF01057.12 CCF45860.1 - 0.029 13.2 0.0 0.05 12.4 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.1 CCF45860.1 - 0.033 13.5 0.1 0.072 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 CCF45860.1 - 0.045 13.3 0.0 0.071 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CCF45860.1 - 0.078 13.2 0.0 0.6 10.4 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.1 CCF45860.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain ORC5_C PF14630.1 CCF45861.1 - 3.6e-43 147.9 0.0 5.5e-43 147.3 0.0 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.1 CCF45861.1 - 4.6e-14 52.8 0.0 1.2e-13 51.5 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 CCF45861.1 - 0.0007 19.7 0.0 0.0019 18.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.8 CCF45861.1 - 0.024 13.5 0.0 0.055 12.3 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Arch_ATPase PF01637.13 CCF45861.1 - 0.12 11.9 0.0 0.28 10.8 0.0 1.6 2 1 0 2 2 2 0 Archaeal ATPase TrwB_AAD_bind PF10412.4 CCF45861.1 - 0.17 10.4 0.0 0.26 9.8 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Abhydrolase_2 PF02230.11 CCF45862.1 - 1.8e-25 89.6 0.0 6.7e-17 61.6 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 CCF45862.1 - 0.0045 16.7 0.0 0.0062 16.2 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF45862.1 - 0.0072 16.2 0.1 0.031 14.1 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF45862.1 - 0.023 13.9 0.1 0.1 11.8 0.0 2.1 2 1 0 2 2 2 0 Prolyl oligopeptidase family CFEM PF05730.6 CCF45863.1 - 0.0019 17.9 1.6 0.0019 17.9 1.1 1.5 2 0 0 2 2 2 1 CFEM domain FAD-oxidase_C PF02913.14 CCF45865.1 - 9.6e-60 201.9 2.9 1.2e-59 201.6 0.5 2.0 2 0 0 2 2 2 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 CCF45865.1 - 1.5e-37 128.1 0.0 3.5e-37 126.9 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain Clr5 PF14420.1 CCF45866.1 - 3.2e-19 68.5 3.6 4.5e-19 68.0 0.6 2.6 2 0 0 2 2 2 1 Clr5 domain TAXi_C PF14541.1 CCF45866.1 - 0.032 13.7 0.2 0.085 12.4 0.0 1.8 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal ECH PF00378.15 CCF45867.1 - 4.8e-35 120.8 0.0 6.1e-35 120.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family SPRY PF00622.23 CCF45868.1 - 5.5e-07 29.6 0.0 9.4e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 SPRY domain Glyco_trans_4_4 PF13579.1 CCF45870.1 - 0.093 12.8 3.6 0.1 12.7 2.5 1.2 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain Herpes_DNAp_acc PF04929.7 CCF45872.1 - 0.13 11.2 1.2 0.15 11.0 0.8 1.0 1 0 0 1 1 1 0 Herpes DNA replication accessory factor SURF2 PF05477.6 CCF45872.1 - 0.18 10.9 5.9 0.18 10.8 4.1 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Lyase_aromatic PF00221.14 CCF45874.1 - 3e-33 114.9 0.2 4.4e-33 114.4 0.1 1.1 1 0 0 1 1 1 1 Aromatic amino acid lyase Glyco_hydro_3_C PF01915.17 CCF45875.1 - 7.6e-27 94.2 0.0 1e-26 93.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 CCF45875.1 - 1.7e-08 34.2 0.0 3.7e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF2372 PF10178.4 CCF45876.1 - 0.00045 20.3 0.0 0.00073 19.6 0.0 1.4 1 1 0 1 1 1 1 Uncharacterised conserved protein (DUF2372) Mac PF12464.3 CCF45877.1 - 8.1e-20 70.5 0.0 1.2e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep PF00132.19 CCF45877.1 - 1.3e-16 59.2 8.5 5.7e-13 47.7 2.0 3.8 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 CCF45877.1 - 6.9e-12 44.7 3.2 6.9e-12 44.7 2.2 3.3 4 0 0 4 4 4 1 Hexapeptide repeat of succinyl-transferase Subtilosin_A PF11420.3 CCF45877.1 - 0.014 15.4 0.5 0.043 13.8 0.1 2.0 2 0 0 2 2 2 0 Bacteriocin subtilosin A Pro_isomerase PF00160.16 CCF45878.1 - 1.1e-47 162.1 0.0 1.2e-47 161.9 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SNARE_assoc PF09335.6 CCF45880.1 - 2.2e-10 40.7 8.8 2.2e-10 40.7 6.1 2.0 2 0 0 2 2 2 1 SNARE associated Golgi protein DUF1771 PF08590.5 CCF45881.1 - 9.4e-14 51.1 10.1 9.4e-14 51.1 7.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.16 CCF45881.1 - 6.3e-10 39.1 0.1 2.4e-09 37.2 0.0 2.0 2 0 0 2 2 2 1 Smr domain zf-CCCH PF00642.19 CCF45881.1 - 2.6e-07 30.1 3.5 0.00078 19.0 0.3 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) HBS1_N PF08938.5 CCF45881.1 - 0.0083 16.2 0.4 0.023 14.7 0.0 1.8 2 0 0 2 2 2 1 HBS1 N-terminus Terpene_synth_C PF03936.11 CCF45881.1 - 0.088 12.0 0.2 0.14 11.4 0.2 1.2 1 0 0 1 1 1 0 Terpene synthase family, metal binding domain Cupin_8 PF13621.1 CCF45882.1 - 2.5e-20 73.0 0.1 9.6e-20 71.1 0.1 1.8 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 CCF45882.1 - 5.2e-10 39.5 0.1 1.5e-09 38.0 0.0 1.8 1 1 0 1 1 1 1 JmjC domain, hydroxylase F-box-like PF12937.2 CCF45882.1 - 3.8e-05 23.3 0.3 8.4e-05 22.2 0.2 1.6 1 0 0 1 1 1 1 F-box-like Cupin_4 PF08007.7 CCF45882.1 - 0.0069 15.6 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein F-box PF00646.28 CCF45882.1 - 0.0084 15.7 0.9 0.018 14.6 0.6 1.5 1 0 0 1 1 1 1 F-box domain Peptidase_S8 PF00082.17 CCF45883.1 - 4.1e-21 75.3 5.6 4.7e-21 75.1 3.9 1.0 1 0 0 1 1 1 1 Subtilase family p450 PF00067.17 CCF45885.1 - 7.2e-14 51.1 0.0 7.2e-14 51.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 WWbp PF10349.4 CCF45886.1 - 5.1 8.0 14.5 5.2 7.9 10.0 1.1 1 0 0 1 1 1 0 WW-domain ligand protein ChaC PF04752.7 CCF45887.1 - 1.9e-36 125.6 0.0 2.5e-36 125.3 0.0 1.1 1 0 0 1 1 1 1 ChaC-like protein Zip PF02535.17 CCF45888.1 - 5.3e-14 51.9 0.2 5.8e-14 51.8 0.1 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter DUF3185 PF11381.3 CCF45888.1 - 0.041 13.6 0.7 0.24 11.1 0.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3185) Glyco_hydro_114 PF03537.8 CCF45888.1 - 0.083 12.6 0.0 0.16 11.7 0.0 1.4 1 1 0 1 1 1 0 Glycoside-hydrolase family GH114 Fungal_trans PF04082.13 CCF45890.1 - 8.2e-20 70.7 0.2 1.3e-19 70.1 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain URO-D PF01208.12 CCF45891.1 - 0.00051 19.0 0.0 0.00055 18.9 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Mito_fiss_reg PF05308.6 CCF45893.1 - 0.38 10.0 2.0 0.46 9.7 1.4 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator Sugar_tr PF00083.19 CCF45894.1 - 4.7e-07 28.7 1.8 6.7e-07 28.2 1.2 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter ABC_tran PF00005.22 CCF45895.1 - 7.1e-43 146.1 0.0 3e-25 89.0 0.0 3.1 3 0 0 3 3 3 2 ABC transporter ABC_membrane PF00664.18 CCF45895.1 - 3.6e-28 98.7 35.4 6.5e-28 97.9 7.6 3.0 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.14 CCF45895.1 - 1.4e-11 44.0 3.2 0.0083 15.3 0.1 4.2 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF45895.1 - 5.6e-10 39.6 0.7 0.16 11.8 0.0 4.3 3 1 1 4 4 4 3 AAA domain AAA_22 PF13401.1 CCF45895.1 - 3.3e-08 33.7 0.0 0.0047 17.0 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.1 CCF45895.1 - 4.1e-07 29.4 2.0 0.0038 16.7 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 CCF45895.1 - 1.2e-05 25.4 2.9 0.0051 16.8 0.1 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.1 CCF45895.1 - 2.3e-05 24.8 1.1 0.0066 16.8 0.2 2.3 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 CCF45895.1 - 4.6e-05 22.6 0.3 0.29 10.3 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_25 PF13481.1 CCF45895.1 - 5.4e-05 22.6 0.0 0.074 12.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_10 PF12846.2 CCF45895.1 - 0.00011 21.7 1.2 0.28 10.5 0.0 2.3 2 0 0 2 2 2 2 AAA-like domain T2SE PF00437.15 CCF45895.1 - 0.00018 20.5 1.6 0.18 10.6 0.1 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein cobW PF02492.14 CCF45895.1 - 0.00065 19.1 2.5 0.24 10.8 0.5 2.6 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain Miro PF08477.8 CCF45895.1 - 0.00077 19.9 0.2 0.16 12.4 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein MobB PF03205.9 CCF45895.1 - 0.00082 19.0 1.9 0.085 12.5 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B SbcCD_C PF13558.1 CCF45895.1 - 0.0014 18.5 0.1 1 9.3 0.1 3.1 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA PF00004.24 CCF45895.1 - 0.0015 18.7 0.9 0.32 11.1 0.0 3.2 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 CCF45895.1 - 0.0021 17.9 0.5 0.49 10.2 0.0 2.8 3 0 0 3 3 2 1 AAA domain ATP_bind_1 PF03029.12 CCF45895.1 - 0.0035 16.9 3.0 0.12 11.9 0.0 3.3 3 0 0 3 3 3 1 Conserved hypothetical ATP binding protein AAA_5 PF07728.9 CCF45895.1 - 0.0062 16.2 0.6 1.8 8.2 0.0 3.5 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 CCF45895.1 - 0.0085 16.3 0.4 0.67 10.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CCF45895.1 - 0.011 15.5 1.9 4.1 7.2 0.0 3.1 3 0 0 3 3 2 0 Part of AAA domain DEAD PF00270.24 CCF45895.1 - 0.013 15.0 2.9 2.6 7.4 0.0 3.2 3 0 0 3 3 3 0 DEAD/DEAH box helicase AAA_17 PF13207.1 CCF45895.1 - 0.017 15.9 1.4 0.56 11.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 CCF45895.1 - 0.024 14.2 2.3 2.9 7.5 0.0 2.6 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.1 CCF45895.1 - 0.036 13.6 2.3 5.5 6.5 0.0 3.2 3 0 0 3 3 3 0 AAA domain ATP-synt_ab PF00006.20 CCF45895.1 - 0.037 13.5 0.2 1.7 8.0 0.0 2.6 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.1 CCF45895.1 - 0.046 13.3 0.2 0.43 10.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 CCF45895.1 - 0.076 12.6 1.8 12 5.5 0.1 2.7 3 0 0 3 3 3 0 Archaeal ATPase IstB_IS21 PF01695.12 CCF45895.1 - 0.097 12.0 5.5 1.8 7.9 0.0 3.8 4 0 0 4 4 4 0 IstB-like ATP binding protein RNA_helicase PF00910.17 CCF45895.1 - 0.1 12.8 0.1 8.5 6.6 0.0 3.1 3 0 0 3 3 3 0 RNA helicase NTPase_1 PF03266.10 CCF45895.1 - 0.11 12.2 4.1 9.4 5.9 0.0 3.3 3 0 0 3 3 3 0 NTPase TrwB_AAD_bind PF10412.4 CCF45895.1 - 0.13 10.8 1.5 3 6.3 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Adeno_IVa2 PF02456.10 CCF45895.1 - 0.17 10.5 0.2 7.1 5.1 0.0 2.3 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_14 PF13173.1 CCF45895.1 - 0.18 11.6 1.4 18 5.2 0.1 3.0 3 0 0 3 3 3 0 AAA domain Dynamin_N PF00350.18 CCF45895.1 - 0.19 11.5 5.1 0.45 10.3 0.1 2.7 3 0 0 3 3 2 0 Dynamin family Zeta_toxin PF06414.7 CCF45895.1 - 0.21 10.6 0.2 7.9 5.5 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_28 PF13521.1 CCF45895.1 - 0.46 10.4 3.1 12 5.8 0.0 3.1 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.13 CCF45895.1 - 0.74 9.2 2.8 2.2 7.7 0.1 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family TPR_12 PF13424.1 CCF45896.1 - 4.1e-08 33.0 10.6 8e-06 25.7 1.3 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 CCF45896.1 - 1e-07 31.2 6.6 0.065 13.1 0.0 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 CCF45896.1 - 3.4e-05 24.0 14.7 0.0097 16.4 0.1 5.1 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 CCF45896.1 - 3.6e-05 23.1 0.8 0.53 9.9 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.1 CCF45896.1 - 4.9e-05 23.5 4.3 0.42 11.1 0.0 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 CCF45896.1 - 0.00033 21.2 13.5 0.00038 21.0 1.3 3.9 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 CCF45896.1 - 0.00036 20.1 10.0 0.0023 17.5 0.7 3.7 3 1 0 4 4 4 1 TPR repeat TPR_8 PF13181.1 CCF45896.1 - 0.00039 20.0 0.0 2.9 7.8 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 CCF45896.1 - 0.00066 19.2 10.2 0.24 11.2 0.1 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 CCF45896.1 - 0.024 14.9 5.3 1 9.7 0.0 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat RasGAP PF00616.14 CCF45896.1 - 0.047 13.3 0.1 0.082 12.5 0.0 1.3 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase TPR_17 PF13431.1 CCF45896.1 - 0.066 13.4 0.4 3.6 8.0 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.9 CCF45896.1 - 0.073 13.5 19.6 0.48 11.0 0.2 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.1 CCF45896.1 - 0.089 12.7 13.6 2.9 7.9 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Ras PF00071.17 CCF45898.1 - 2e-47 160.5 0.0 2.8e-47 160.1 0.0 1.2 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF45898.1 - 7.6e-12 45.7 0.0 1.2e-11 45.1 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CCF45898.1 - 5.6e-05 22.4 0.0 9.9e-05 21.6 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 CCF45899.1 - 1.5e-49 167.4 2.0 2.9e-47 160.0 0.5 2.0 2 0 0 2 2 2 2 Ras family Miro PF08477.8 CCF45899.1 - 1e-11 45.3 0.2 3e-11 43.8 0.1 1.9 2 1 0 2 2 2 1 Miro-like protein Arf PF00025.16 CCF45899.1 - 6.5e-11 41.7 0.1 1.3e-10 40.8 0.1 1.5 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 CCF45899.1 - 9.5e-09 34.9 0.0 1.1e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 CCF45899.1 - 0.00021 20.5 0.1 0.00059 19.0 0.0 1.6 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region TCP PF03634.8 CCF45899.1 - 0.099 13.0 0.2 0.16 12.3 0.1 1.2 1 0 0 1 1 1 0 TCP family transcription factor Amidase02_C PF12123.3 CCF45899.1 - 0.14 11.8 0.0 0.92 9.1 0.0 2.1 2 0 0 2 2 2 0 N-acetylmuramoyl-l-alanine amidase Amidohydro_2 PF04909.9 CCF45900.1 - 1.1e-43 149.8 0.1 1.3e-43 149.5 0.1 1.2 1 0 0 1 1 1 1 Amidohydrolase TatD_DNase PF01026.16 CCF45900.1 - 0.026 13.7 0.0 0.063 12.4 0.0 1.6 2 0 0 2 2 2 0 TatD related DNase PGA2 PF07543.7 CCF45902.1 - 0.0066 16.2 0.4 0.0083 15.9 0.2 1.0 1 0 0 1 1 1 1 Protein trafficking PGA2 RXT2_N PF08595.6 CCF45902.1 - 0.092 12.5 1.1 0.11 12.2 0.7 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF2457 PF10446.4 CCF45902.1 - 0.17 10.5 4.3 0.18 10.5 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nucleoplasmin PF03066.10 CCF45902.1 - 0.21 11.0 1.4 0.21 11.1 1.0 1.1 1 0 0 1 1 1 0 Nucleoplasmin PBP1_TM PF14812.1 CCF45902.1 - 0.32 11.3 3.0 0.37 11.1 2.1 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Spt5_N PF11942.3 CCF45902.1 - 7.6 7.2 11.1 6 7.5 4.3 2.0 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal GATase_5 PF13507.1 CCF45903.1 - 6.6e-32 110.4 0.2 1e-31 109.8 0.1 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.17 CCF45903.1 - 3.3e-17 62.9 0.0 6.1e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain SOR_SNZ PF01680.12 CCF45904.1 - 6.9e-25 87.8 2.1 8.5e-25 87.5 1.4 1.0 1 0 0 1 1 1 1 SOR/SNZ family MlrC_C PF07171.7 CCF45904.1 - 0.37 10.3 3.4 0.39 10.2 2.4 1.0 1 0 0 1 1 1 0 MlrC C-terminus RNA_pol_Rpb5_N PF03871.9 CCF45905.1 - 6.1e-28 97.0 0.0 8.8e-28 96.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain RNA_pol_Rpb5_C PF01191.14 CCF45905.1 - 2.4e-12 46.2 0.1 4.8e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain Cas_Cas6 PF01881.11 CCF45906.1 - 0.13 12.4 0.8 0.15 12.2 0.5 1.0 1 0 0 1 1 1 0 CRISPR associated protein Cas6 Kinetocho_Slk19 PF12709.2 CCF45906.1 - 0.16 12.0 4.1 0.13 12.3 1.9 1.6 1 1 0 1 1 1 0 Central kinetochore-associated AATF-Che1 PF13339.1 CCF45906.1 - 0.23 11.6 5.9 0.28 11.3 4.1 1.2 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor DUF342 PF03961.8 CCF45906.1 - 0.25 9.7 4.1 0.27 9.6 2.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) PRP1_N PF06424.7 CCF45906.1 - 1.2 9.4 7.1 1.3 9.2 4.9 1.1 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal DUF4407 PF14362.1 CCF45906.1 - 5.4 5.8 8.9 5.7 5.7 6.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Sec2p PF06428.6 CCF45907.1 - 1.1e-24 86.1 12.8 1.1e-24 86.1 8.9 2.3 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p DUF3348 PF11828.3 CCF45907.1 - 0.46 9.8 15.2 0.15 11.4 6.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3348) DUF2220 PF09983.4 CCF45907.1 - 1 8.4 7.6 1.2 8.3 4.3 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) Nucleocapsid-N PF11030.3 CCF45909.1 - 0.038 13.8 4.6 0.05 13.3 3.2 1.2 1 0 0 1 1 1 0 Nucleocapsid protein N DUF1777 PF08648.7 CCF45909.1 - 0.41 10.3 24.6 0.52 10.0 17.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) MIP-T3 PF10243.4 CCF45909.1 - 0.62 8.4 18.2 0.66 8.3 12.6 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF4220 PF13968.1 CCF45909.1 - 5.2 6.0 5.7 6.5 5.7 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) Peptidase_S64 PF08192.6 CCF45909.1 - 9.5 4.4 7.7 11 4.2 5.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 CTNNB1_binding PF08347.6 CCF45910.1 - 0.015 15.5 0.3 0.025 14.8 0.1 1.3 1 1 0 1 1 1 0 N-terminal CTNNB1 binding p450 PF00067.17 CCF45912.1 - 7.5e-42 143.4 0.0 9.2e-42 143.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 EMP70 PF02990.11 CCF45913.1 - 6.7e-89 298.7 33.5 8.1e-89 298.4 23.2 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 DUF2065 PF09838.4 CCF45914.1 - 0.0045 16.6 0.1 0.01 15.5 0.1 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2065) RGS PF00615.14 CCF45914.1 - 0.014 15.5 0.0 0.033 14.2 0.0 1.6 2 0 0 2 2 2 0 Regulator of G protein signaling domain DUF4184 PF13803.1 CCF45914.1 - 0.16 11.2 1.2 0.23 10.7 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4184) DUF1625 PF07787.7 CCF45914.1 - 0.17 11.1 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1625) Helicase_C PF00271.26 CCF45916.1 - 0.00058 19.6 0.0 0.0009 19.0 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Hexapep PF00132.19 CCF45917.1 - 1.2e-07 30.9 8.4 0.0011 18.4 0.6 4.6 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 CCF45917.1 - 1.9e-06 27.3 2.4 0.00013 21.4 0.6 3.2 2 1 1 3 3 3 2 Hexapeptide repeat of succinyl-transferase Meth_synt_2 PF01717.13 CCF45918.1 - 9.4e-11 41.2 0.0 1.1e-08 34.4 0.0 2.1 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.7 CCF45918.1 - 0.011 15.0 0.0 0.073 12.3 0.0 2.1 2 0 0 2 2 2 0 Cobalamin-independent synthase, N-terminal domain F-box-like PF12937.2 CCF45919.1 - 8.4e-08 31.8 5.6 1e-07 31.5 2.2 2.4 2 1 0 2 2 2 1 F-box-like F-box PF00646.28 CCF45919.1 - 0.00085 18.9 5.7 0.11 12.2 4.0 3.2 2 1 0 2 2 2 1 F-box domain F-box-like_2 PF13013.1 CCF45919.1 - 0.064 12.9 0.0 0.34 10.6 0.0 2.1 2 0 0 2 2 2 0 F-box-like domain GATase_5 PF13507.1 CCF45921.1 - 9.6e-88 293.4 0.0 1.1e-87 293.1 0.0 1.0 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain DUF603 PF04645.7 CCF45922.1 - 0.022 14.7 0.1 0.033 14.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF603 RGCC PF15151.1 CCF45923.1 - 0.22 11.9 3.3 0.91 9.9 0.2 2.6 1 1 2 3 3 3 0 Response gene to complement 32 protein family DUF488 PF04343.8 CCF45923.1 - 0.84 10.0 5.1 0.95 9.8 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function, DUF488 Zn_clus PF00172.13 CCF45925.1 - 2.9e-08 33.4 11.3 4.7e-08 32.8 7.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UBX PF00789.15 CCF45926.1 - 7.2e-12 45.2 0.0 1.3e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 UBX domain CAF-1_p150 PF11600.3 CCF45926.1 - 0.011 15.0 17.5 0.022 14.1 12.1 1.5 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal TFIIA PF03153.8 CCF45926.1 - 0.049 13.5 7.6 0.062 13.2 5.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 CCF45926.1 - 0.055 11.7 8.8 0.07 11.3 6.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FancD2 PF14631.1 CCF45926.1 - 2.8 4.9 6.4 4 4.3 4.5 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Borrelia_P83 PF05262.6 CCF45926.1 - 4.9 5.3 17.5 6.8 4.8 12.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein FAM216B PF15107.1 CCF45927.1 - 0.14 12.0 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 FAM216B protein family Peptidase_S8 PF00082.17 CCF45929.1 - 1.6e-45 155.4 0.0 6.9e-45 153.3 0.0 1.9 1 1 0 1 1 1 1 Subtilase family PA PF02225.17 CCF45929.1 - 3.2e-10 39.5 0.0 7.9e-10 38.3 0.0 1.7 1 0 0 1 1 1 1 PA domain DUF1034 PF06280.7 CCF45929.1 - 1.1e-06 28.9 0.0 7.9e-06 26.2 0.0 2.3 2 0 0 2 2 2 1 Fn3-like domain (DUF1034) DUF3328 PF11807.3 CCF45931.1 - 8.9e-24 84.3 0.7 1.1e-23 84.0 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.3 CCF45932.1 - 4.7e-07 29.7 0.1 4.7e-07 29.7 0.0 1.2 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) R3H PF01424.17 CCF45937.1 - 1.9e-14 53.0 0.1 3.6e-14 52.2 0.1 1.4 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.12 CCF45937.1 - 6.2e-06 26.0 48.5 8e-05 22.5 9.2 9.2 9 1 0 9 9 9 4 NF-X1 type zinc finger Glucosamine_iso PF01182.15 CCF45939.1 - 1.6e-33 116.0 0.0 1.9e-33 115.9 0.0 1.1 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase CAF1-p150_N PF15557.1 CCF45940.1 - 0.037 13.3 0.8 0.042 13.1 0.6 1.2 1 0 0 1 1 1 0 CAF1 complex subunit p150, region binding to PCNA DUF4215 PF13948.1 CCF45940.1 - 0.36 11.0 5.7 0.53 10.5 4.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4215) Zn_clus PF00172.13 CCF45940.1 - 0.85 9.5 10.9 1.7 8.6 2.6 2.4 1 1 1 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4231 PF14015.1 CCF45941.1 - 0.35 10.8 2.1 2.2 8.3 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) Leu_zip PF15294.1 CCF45942.1 - 0.04 13.0 1.2 0.095 11.7 0.0 1.8 2 0 0 2 2 2 0 Leucine zipper DUF2046 PF09755.4 CCF45942.1 - 0.07 12.0 2.0 0.14 11.0 1.4 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) Pox_A_type_inc PF04508.7 CCF45942.1 - 0.34 10.7 3.7 0.15 11.8 0.4 2.1 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat DivIC PF04977.10 CCF45942.1 - 4.8 6.7 7.0 2.5 7.6 0.1 2.3 2 0 0 2 2 2 0 Septum formation initiator Herpes_TAF50 PF03326.8 CCF45943.1 - 0.19 10.6 15.6 0.33 9.8 10.8 1.5 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) HET PF06985.6 CCF45944.1 - 0.014 15.5 0.6 2 8.5 0.0 2.7 1 1 1 2 2 2 0 Heterokaryon incompatibility protein (HET) Pkinase PF00069.20 CCF45945.1 - 7.9e-10 38.3 0.2 5.6e-08 32.2 0.1 2.4 1 1 0 1 1 1 1 Protein kinase domain Choline_kinase PF01633.15 CCF45945.1 - 1.2e-05 25.0 0.0 2.2e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase_Tyr PF07714.12 CCF45945.1 - 3.6e-05 22.9 0.2 0.0011 18.1 0.1 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 CCF45945.1 - 0.00012 21.8 1.1 0.0003 20.5 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 CCF45945.1 - 0.015 14.6 0.1 0.049 12.9 0.0 1.7 2 0 0 2 2 2 0 RIO1 family Kdo PF06293.9 CCF45945.1 - 0.071 12.1 0.9 0.84 8.6 0.1 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.6 CCF45945.1 - 0.13 11.0 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase AAA_22 PF13401.1 CCF45947.1 - 1.5e-05 25.1 0.1 6.5e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain DEAD PF00270.24 CCF45947.1 - 4.1e-05 23.1 0.1 0.00011 21.7 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 CCF45947.1 - 0.0033 16.3 0.1 0.019 13.8 0.0 2.0 2 0 0 2 2 2 1 Type II/IV secretion system protein KaiC PF06745.8 CCF45947.1 - 0.011 14.8 0.0 0.021 13.9 0.0 1.5 1 0 0 1 1 1 0 KaiC PhoH PF02562.11 CCF45947.1 - 0.011 14.9 0.1 0.044 13.0 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_14 PF13173.1 CCF45947.1 - 0.046 13.6 0.2 0.42 10.5 0.0 2.5 2 1 0 2 2 2 0 AAA domain Miro PF08477.8 CCF45947.1 - 0.054 13.9 1.5 0.27 11.7 0.1 2.8 2 1 0 2 2 2 0 Miro-like protein FtsK_SpoIIIE PF01580.13 CCF45947.1 - 0.063 12.7 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family ResIII PF04851.10 CCF45947.1 - 0.15 11.9 6.7 0.81 9.4 0.0 3.2 4 0 0 4 4 4 0 Type III restriction enzyme, res subunit Nop14 PF04147.7 CCF45947.1 - 8.4 4.1 31.2 0.098 10.5 12.6 2.0 2 0 0 2 2 2 0 Nop14-like family Daxx PF03344.10 CCF45947.1 - 9.1 4.6 25.5 0.018 13.5 9.4 2.0 2 0 0 2 2 2 0 Daxx Family Tyrosinase PF00264.15 CCF45948.1 - 5e-36 124.9 2.3 6.5e-36 124.5 1.6 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase RTA1 PF04479.8 CCF45949.1 - 3.4e-56 190.2 13.4 4.9e-56 189.7 9.3 1.2 1 0 0 1 1 1 1 RTA1 like protein Kei1 PF08552.6 CCF45949.1 - 6.9e-05 22.5 0.0 0.00045 19.9 0.0 2.2 2 0 0 2 2 2 1 Inositolphosphorylceramide synthase subunit Kei1 Caveolin PF01146.12 CCF45949.1 - 0.43 10.1 5.3 0.2 11.2 0.2 2.4 2 0 0 2 2 2 0 Caveolin DUF21 PF01595.15 CCF45949.1 - 7.6 5.7 12.6 0.052 12.8 2.3 2.1 3 0 0 3 3 3 0 Domain of unknown function DUF21 PALP PF00291.20 CCF45951.1 - 1.9e-24 86.4 0.0 3.4e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Rhodanese PF00581.15 CCF45951.1 - 1.3e-08 35.1 0.0 3.9e-08 33.6 0.0 1.8 1 1 0 1 1 1 1 Rhodanese-like domain Asparaginase PF00710.15 CCF45952.1 - 8.2e-40 136.5 0.0 1.1e-39 136.2 0.0 1.1 1 0 0 1 1 1 1 Asparaginase Acetyltransf_9 PF13527.1 CCF45952.1 - 0.16 11.7 0.0 3.8 7.3 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acyl-CoA_dh_1 PF00441.19 CCF45955.1 - 1.9e-22 79.9 0.3 2.9e-22 79.3 0.2 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 CCF45955.1 - 3.2e-20 72.7 0.4 6.8e-20 71.7 0.3 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 CCF45955.1 - 2.7e-16 58.8 0.0 6.2e-16 57.6 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 CCF45955.1 - 1.4e-06 28.6 0.3 2.1e-06 28.0 0.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Glyco_hydro_3_C PF01915.17 CCF45957.1 - 1.2e-49 168.8 0.2 6.3e-49 166.5 0.2 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 CCF45957.1 - 8.3e-24 83.3 0.0 1.4e-23 82.6 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain HAD PF12710.2 CCF45958.1 - 4.8e-09 36.6 0.1 7.6e-09 36.0 0.1 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.7 CCF45958.1 - 0.0018 17.5 0.0 0.0069 15.5 0.0 1.8 1 1 0 1 1 1 1 Putative Phosphatase Hydrolase PF00702.21 CCF45958.1 - 0.016 15.6 0.2 0.24 11.8 0.1 2.5 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.7 CCF45958.1 - 0.042 13.1 0.0 0.097 11.9 0.0 1.7 2 0 0 2 2 2 0 Pyrimidine 5'-nucleotidase (UMPH-1) DUF1056 PF06341.6 CCF45959.1 - 0.092 12.7 0.7 0.092 12.7 0.5 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1056) Vps5 PF09325.5 CCF45961.1 - 3.9e-87 291.4 7.9 5.9e-87 290.8 5.5 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.19 CCF45961.1 - 4.3e-25 87.7 0.0 9.7e-25 86.5 0.0 1.6 1 0 0 1 1 1 1 PX domain BAR_2 PF10455.4 CCF45961.1 - 0.0029 16.5 2.4 0.0044 15.9 1.7 1.3 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3_WASP_bdg PF10456.4 CCF45961.1 - 0.0037 16.5 1.0 0.035 13.3 0.6 2.1 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein BAR PF03114.13 CCF45961.1 - 0.0047 16.4 6.5 0.0073 15.8 4.5 1.2 1 0 0 1 1 1 1 BAR domain FAD_binding_3 PF01494.14 CCF45962.1 - 3.7e-18 65.7 0.0 7.4e-09 35.1 0.0 2.8 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.1 CCF45962.1 - 8.9e-05 22.4 0.0 0.00018 21.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 CCF45962.1 - 0.00036 19.7 0.0 0.0006 18.9 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.1 CCF45962.1 - 0.00037 20.6 0.0 0.00061 19.8 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CCF45962.1 - 0.00099 19.0 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.5 CCF45962.1 - 0.0012 17.7 0.0 0.0036 16.1 0.0 1.7 1 1 0 1 1 1 1 Squalene epoxidase NAD_Gly3P_dh_N PF01210.18 CCF45962.1 - 0.017 14.8 0.0 0.036 13.7 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TrkA_N PF02254.13 CCF45962.1 - 0.019 14.9 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain DAO PF01266.19 CCF45962.1 - 0.1 11.4 0.0 0.31 9.9 0.0 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 CCF45962.1 - 0.12 11.2 0.0 0.28 10.0 0.0 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein HI0933_like PF03486.9 CCF45962.1 - 0.16 10.3 0.0 0.8 8.1 0.0 1.9 2 0 0 2 2 2 0 HI0933-like protein Fungal_trans PF04082.13 CCF45963.1 - 5.6e-16 58.1 0.0 1e-15 57.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF45963.1 - 0.19 11.6 5.1 0.39 10.6 3.5 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_9_N PF15420.1 CCF45964.1 - 0.23 11.1 12.0 0.29 10.8 7.8 1.5 1 1 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus DUF3377 PF11857.3 CCF45964.1 - 0.28 10.8 5.1 0.16 11.5 2.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3377) Virul_fac_BrkB PF03631.10 CCF45964.1 - 0.46 9.7 13.6 0.58 9.4 9.4 1.1 1 0 0 1 1 1 0 Virulence factor BrkB Tetraspannin PF00335.15 CCF45964.1 - 0.53 9.5 10.8 2.3 7.4 7.5 1.9 1 1 0 1 1 1 0 Tetraspanin family Polysacc_synt PF01943.12 CCF45964.1 - 0.69 9.1 14.3 1.6 7.9 10.0 1.6 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein DUF2207 PF09972.4 CCF45964.1 - 1.9 6.9 4.9 2.6 6.5 3.4 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) FA_desaturase PF00487.19 CCF45964.1 - 5.6 6.3 8.3 1.3 8.4 3.4 1.7 1 1 1 2 2 2 0 Fatty acid desaturase UPF0182 PF03699.8 CCF45964.1 - 7.8 4.2 6.5 9.6 3.9 4.5 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Pep3_Vps18 PF05131.9 CCF45967.1 - 2.6e-46 156.7 0.0 4.4e-46 155.9 0.0 1.4 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family DAO PF01266.19 CCF45969.1 - 2.9e-09 36.3 1.3 5.8e-05 22.1 0.1 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 CCF45969.1 - 5.1e-05 23.0 0.1 0.00012 21.9 0.1 1.6 1 1 0 1 1 1 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.14 CCF45969.1 - 6.1e-05 22.2 0.2 0.0001 21.4 0.1 1.3 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.1 CCF45969.1 - 0.00017 21.7 0.0 0.00035 20.6 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CCF45969.1 - 0.00037 20.4 0.0 0.0011 18.9 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF45969.1 - 0.008 16.0 0.4 0.015 15.1 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF45969.1 - 0.015 14.2 0.0 0.022 13.6 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.17 CCF45969.1 - 0.024 13.5 0.1 0.033 13.0 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A HI0933_like PF03486.9 CCF45969.1 - 0.043 12.2 0.0 0.064 11.7 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein 3HCDH_N PF02737.13 CCF45969.1 - 0.12 11.9 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Abhydrolase_6 PF12697.2 CCF45971.1 - 1.9e-34 119.5 2.6 3.6e-34 118.6 1.8 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF45971.1 - 2.9e-19 69.5 0.1 2.6e-16 59.9 0.1 2.4 2 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF45971.1 - 2.6e-14 53.1 0.1 5.2e-14 52.2 0.1 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CCF45971.1 - 2.5e-05 24.0 0.0 5e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase AXE1 PF05448.7 CCF45971.1 - 0.015 13.8 0.0 0.024 13.1 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) p450 PF00067.17 CCF45972.1 - 4.9e-47 160.5 0.0 6.7e-47 160.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 GMC_oxred_N PF00732.14 CCF45973.1 - 5.9e-56 189.7 0.0 7.5e-56 189.4 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 CCF45973.1 - 1.6e-34 119.2 0.0 5.1e-34 117.6 0.0 1.9 2 0 0 2 2 2 1 GMC oxidoreductase DAO PF01266.19 CCF45973.1 - 2.7e-05 23.2 5.4 0.00036 19.5 0.4 2.5 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF45973.1 - 0.00012 21.9 0.1 0.00038 20.4 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 CCF45973.1 - 0.00016 20.6 0.6 0.00042 19.3 0.2 1.8 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_2 PF00890.19 CCF45973.1 - 0.00058 18.8 0.7 0.0063 15.4 0.1 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.9 CCF45973.1 - 0.0022 17.8 0.0 0.11 12.3 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF45973.1 - 0.0027 16.8 0.7 0.058 12.4 0.1 2.2 2 0 0 2 2 2 1 Thi4 family K_oxygenase PF13434.1 CCF45973.1 - 0.018 13.9 0.3 0.25 10.1 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) PTCB-BRCT PF12738.2 CCF45974.1 - 4.2e-28 96.9 0.6 1.9e-21 75.6 0.1 4.3 4 0 0 4 4 4 2 twin BRCT domain BRCT PF00533.21 CCF45974.1 - 7e-28 96.5 0.1 1e-11 44.7 0.0 5.4 6 0 0 6 6 6 4 BRCA1 C Terminus (BRCT) domain ESCRT-II PF05871.7 CCF45975.1 - 2.3e-49 166.8 0.0 1.7e-48 164.0 0.0 2.0 1 1 0 1 1 1 1 ESCRT-II complex subunit GMC_oxred_C PF05199.8 CCF45976.1 - 9.6e-31 107.0 0.1 1.2e-30 106.7 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase Acetyltransf_1 PF00583.19 CCF45977.1 - 0.00023 21.1 0.0 0.00038 20.4 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 CCF45977.1 - 0.00024 21.2 0.1 0.001 19.1 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 CCF45977.1 - 0.0003 20.8 0.0 0.0004 20.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF45977.1 - 0.027 14.1 0.1 0.15 11.8 0.1 1.9 1 1 0 1 1 1 0 FR47-like protein Pro_CA PF00484.14 CCF45978.1 - 3e-26 92.2 0.0 3.9e-26 91.8 0.0 1.1 1 0 0 1 1 1 1 Carbonic anhydrase SET PF00856.23 CCF45979.1 - 3.6e-21 76.1 0.7 3.6e-21 76.1 0.5 2.6 2 2 0 2 2 2 1 SET domain Aldedh PF00171.17 CCF45980.1 - 3.2e-10 38.9 0.2 0.00029 19.3 0.1 2.1 2 0 0 2 2 2 2 Aldehyde dehydrogenase family SEEK1 PF15357.1 CCF45980.1 - 0.08 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Psoriasis susceptibility 1 candidate 1 GMC_oxred_N PF00732.14 CCF45985.1 - 1.9e-11 43.6 0.0 6.7e-06 25.4 0.0 3.0 2 1 0 2 2 2 2 GMC oxidoreductase NAD_binding_8 PF13450.1 CCF45985.1 - 7.2e-05 22.7 0.2 0.00025 20.9 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CCF45985.1 - 0.00054 18.9 0.1 0.00076 18.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 CCF45985.1 - 0.016 15.1 0.0 0.06 13.2 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.11 CCF45985.1 - 0.024 14.0 0.1 0.041 13.3 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.7 CCF45985.1 - 0.028 13.3 0.0 0.05 12.5 0.0 1.4 2 0 0 2 2 2 0 Lycopene cyclase protein HI0933_like PF03486.9 CCF45985.1 - 0.19 10.1 0.8 0.25 9.7 0.5 1.1 1 0 0 1 1 1 0 HI0933-like protein Pec_lyase_C PF00544.14 CCF45986.1 - 4e-24 85.2 1.1 6.5e-24 84.5 0.7 1.3 1 0 0 1 1 1 1 Pectate lyase CBM_1 PF00734.13 CCF45986.1 - 2.6e-13 49.3 13.2 2.6e-13 49.3 9.2 2.3 2 0 0 2 2 2 1 Fungal cellulose binding domain Beta_helix PF13229.1 CCF45986.1 - 1.3e-05 25.0 7.6 5.9e-05 22.8 5.3 2.0 1 1 0 1 1 1 1 Right handed beta helix region CT47 PF15623.1 CCF45986.1 - 0.013 15.2 7.3 0.02 14.6 5.0 1.2 1 0 0 1 1 1 0 Cancer/testis gene family 47 PRCC PF10253.4 CCF45986.1 - 0.27 11.9 4.4 0.46 11.1 3.1 1.3 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting ADH_zinc_N PF00107.21 CCF45989.1 - 1.2e-08 34.5 0.1 1.8e-08 33.9 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CCF45989.1 - 1.3e-07 31.3 0.0 3.4e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Fmp27 PF10344.4 CCF45994.1 - 4.6e-236 785.6 0.4 1.5e-235 783.9 0.0 2.0 2 0 0 2 2 2 1 Mitochondrial protein from FMP27 Apt1 PF10351.4 CCF45994.1 - 5.4e-169 562.8 1.1 5.4e-169 562.8 0.8 2.6 3 0 0 3 3 3 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.4 CCF45994.1 - 5.4e-147 490.0 0.0 5.4e-147 490.0 0.0 2.3 3 0 0 3 3 3 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.4 CCF45994.1 - 2.7e-53 179.9 0.1 6.7e-53 178.6 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_GFWDK PF10347.4 CCF45994.1 - 7.9e-53 178.5 0.0 1.6e-52 177.5 0.0 1.6 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Fmp27_SW PF10305.4 CCF45994.1 - 4e-33 113.9 0.0 1.8e-32 111.8 0.0 2.3 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain RRM_1 PF00076.17 CCF45996.1 - 1.6e-10 40.4 0.0 2.7e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF45996.1 - 7.4e-08 32.2 0.0 1.1e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF45996.1 - 0.0005 19.8 0.1 0.0013 18.4 0.0 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GRP PF07172.6 CCF45996.1 - 0.0032 17.9 5.0 0.0032 17.9 3.5 2.1 2 1 0 2 2 2 1 Glycine rich protein family Fork_head PF00250.13 CCF45997.1 - 1e-11 44.6 0.0 2.1e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Fork head domain BAF1_ABF1 PF04684.8 CCF45997.1 - 0.16 10.7 18.3 0.26 10.0 12.7 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF3772 PF12607.3 CCF45997.1 - 0.18 11.4 1.0 0.38 10.4 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3772) Macoilin PF09726.4 CCF45997.1 - 0.37 9.0 4.5 0.37 9.0 3.1 1.1 1 0 0 1 1 1 0 Transmembrane protein MFS_1 PF07690.11 CCF45998.1 - 2.6e-34 118.4 24.5 3.1e-34 118.2 17.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF45998.1 - 3.3e-16 58.9 10.1 4.4e-16 58.5 7.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter AAA_13 PF13166.1 CCF45999.1 - 0.00043 18.8 0.9 0.00053 18.6 0.6 1.2 1 0 0 1 1 1 1 AAA domain CENP-F_leu_zip PF10473.4 CCF45999.1 - 0.0072 16.1 13.9 0.13 12.1 4.1 2.4 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF812 PF05667.6 CCF45999.1 - 0.0082 14.7 6.7 0.0088 14.5 3.7 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF812) FUSC PF04632.7 CCF45999.1 - 0.011 14.2 3.2 0.013 13.9 2.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family ApoLp-III PF07464.6 CCF45999.1 - 0.015 15.3 0.3 0.015 15.3 0.2 2.1 1 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) TPR_MLP1_2 PF07926.7 CCF45999.1 - 0.017 14.8 7.8 0.014 15.1 4.0 1.9 2 1 0 2 2 1 0 TPR/MLP1/MLP2-like protein EzrA PF06160.7 CCF45999.1 - 0.02 13.0 5.3 0.016 13.4 1.4 1.9 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA NPV_P10 PF05531.7 CCF45999.1 - 0.03 14.5 2.0 0.34 11.2 0.6 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein PilJ PF13675.1 CCF45999.1 - 0.031 14.5 3.8 0.11 12.8 0.8 2.6 1 1 2 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term V_ATPase_I PF01496.14 CCF45999.1 - 0.037 11.8 2.7 0.042 11.7 1.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.6 CCF45999.1 - 0.053 12.1 7.2 0.095 11.3 4.7 1.7 1 1 1 2 2 2 0 Spc7 kinetochore protein EMP24_GP25L PF01105.19 CCF45999.1 - 0.059 13.0 1.0 0.097 12.3 0.7 1.4 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD MAD PF05557.8 CCF45999.1 - 0.078 11.0 12.7 0.9 7.5 5.5 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein YscO PF07321.7 CCF45999.1 - 0.096 12.5 9.8 0.2 11.4 6.8 1.6 1 1 0 1 1 1 0 Type III secretion protein YscO DUF3584 PF12128.3 CCF45999.1 - 0.12 9.6 10.1 0.44 7.8 1.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) FH2 PF02181.18 CCF45999.1 - 0.15 10.9 5.5 1.5 7.6 0.3 2.1 1 1 1 2 2 2 0 Formin Homology 2 Domain Mod_r PF07200.8 CCF45999.1 - 0.15 11.9 5.3 0.06 13.2 0.9 2.1 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein TMF_DNA_bd PF12329.3 CCF45999.1 - 0.17 11.7 17.1 2.2 8.1 1.8 4.1 2 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding WEMBL PF05701.6 CCF45999.1 - 0.31 9.4 15.0 0.31 9.4 4.7 2.4 2 1 1 3 3 3 0 Weak chloroplast movement under blue light Laminin_II PF06009.7 CCF45999.1 - 0.34 10.6 3.1 0.9 9.2 1.7 2.0 1 1 1 2 2 2 0 Laminin Domain II DUF4201 PF13870.1 CCF45999.1 - 0.56 9.6 9.7 0.29 10.5 3.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) Fez1 PF06818.10 CCF45999.1 - 0.63 10.0 15.0 0.39 10.7 8.7 1.7 2 0 0 2 2 2 0 Fez1 Occludin_ELL PF07303.8 CCF45999.1 - 0.66 10.7 3.7 1.1 10.0 1.2 2.2 1 1 1 2 2 2 0 Occludin homology domain IncA PF04156.9 CCF45999.1 - 0.7 9.4 14.0 1.6 8.2 9.7 1.9 1 1 0 1 1 1 0 IncA protein DivIC PF04977.10 CCF45999.1 - 0.72 9.3 10.7 3.4 7.1 0.3 4.0 2 1 1 4 4 4 0 Septum formation initiator V-SNARE PF05008.10 CCF45999.1 - 0.83 9.8 5.0 0.9 9.7 1.6 2.5 2 1 0 3 3 2 0 Vesicle transport v-SNARE protein N-terminus DUF4140 PF13600.1 CCF45999.1 - 0.92 9.9 14.0 2.4 8.6 2.6 3.8 1 1 3 4 4 4 0 N-terminal domain of unknown function (DUF4140) Ax_dynein_light PF10211.4 CCF45999.1 - 1 9.1 11.4 0.12 12.1 0.9 2.5 2 1 1 3 3 2 0 Axonemal dynein light chain Seryl_tRNA_N PF02403.17 CCF45999.1 - 1.1 9.3 10.8 1.7 8.6 0.7 3.2 2 2 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain BLOC1_2 PF10046.4 CCF45999.1 - 1.1 9.4 9.0 0.46 10.6 1.2 2.8 2 1 1 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF972 PF06156.8 CCF45999.1 - 1.1 9.6 5.8 0.91 9.8 0.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF745 PF05335.8 CCF45999.1 - 1.2 8.6 5.7 0.83 9.1 0.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF4407 PF14362.1 CCF45999.1 - 1.4 7.7 9.8 1.2 8.0 1.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) APG6 PF04111.7 CCF45999.1 - 1.4 7.8 11.1 0.6 9.0 3.3 2.0 1 1 1 2 2 2 0 Autophagy protein Apg6 ISG65-75 PF11727.3 CCF45999.1 - 1.5 7.8 7.9 2.3 7.2 1.2 2.1 1 1 1 2 2 2 0 Invariant surface glycoprotein End3 PF12761.2 CCF45999.1 - 1.5 8.4 6.6 4.5 6.8 3.6 2.0 1 1 1 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 DivIVA PF05103.8 CCF45999.1 - 1.7 8.6 9.0 0.5 10.4 1.3 2.4 1 1 1 2 2 2 0 DivIVA protein FlgN PF05130.7 CCF45999.1 - 1.9 8.7 14.1 8.2 6.6 6.5 2.6 1 1 1 2 2 2 0 FlgN protein DUF4510 PF14971.1 CCF45999.1 - 2 8.5 8.3 8.2 6.5 1.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4510) OmpH PF03938.9 CCF45999.1 - 2 8.3 5.4 56 3.6 3.8 2.2 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Syntaxin-6_N PF09177.6 CCF45999.1 - 2.4 8.6 5.8 13 6.3 1.0 3.1 1 1 1 3 3 3 0 Syntaxin 6, N-terminal OEP PF02321.13 CCF45999.1 - 2.5 7.6 5.7 2.3 7.7 3.2 1.4 1 1 0 1 1 1 0 Outer membrane efflux protein Tropomyosin_1 PF12718.2 CCF45999.1 - 2.7 7.8 21.1 0.45 10.3 3.7 2.9 2 1 1 3 3 3 0 Tropomyosin like DUF1192 PF06698.6 CCF45999.1 - 3.4 7.5 11.9 1.6 8.6 2.6 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1192) Mnd1 PF03962.10 CCF45999.1 - 3.9 7.0 10.5 5.4 6.6 2.7 2.5 1 1 1 2 2 2 0 Mnd1 family HALZ PF02183.13 CCF45999.1 - 5.1 6.8 6.6 49 3.7 0.6 3.8 4 0 0 4 4 3 0 Homeobox associated leucine zipper SlyX PF04102.7 CCF45999.1 - 8.1 6.9 9.8 10 6.5 3.6 3.5 3 1 1 4 4 3 0 SlyX BRE1 PF08647.6 CCF45999.1 - 8.4 6.4 10.0 2.4 8.1 2.7 2.9 2 1 1 3 3 2 0 BRE1 E3 ubiquitin ligase GAS PF13851.1 CCF45999.1 - 9.4 5.3 12.6 5.5 6.1 5.1 2.5 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Mito_carr PF00153.22 CCF46002.1 - 1.6e-48 162.3 1.7 1.2e-19 69.7 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Sugar_tr PF00083.19 CCF46004.1 - 6.3e-85 285.4 16.3 7.2e-85 285.2 11.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF46004.1 - 2e-31 108.9 56.7 1.8e-28 99.2 22.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF46004.1 - 1.5e-06 26.7 2.7 4.9e-06 25.0 0.4 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.1 CCF46004.1 - 3.5e-05 22.3 0.8 3.5e-05 22.3 0.6 2.7 2 2 0 2 2 2 2 MFS/sugar transport protein OATP PF03137.15 CCF46004.1 - 0.024 12.7 1.2 0.04 11.9 0.5 1.5 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family ThiS PF02597.15 CCF46006.1 - 6.1e-08 32.9 0.0 7.3e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 ThiS family Ribosomal_S28e PF01200.13 CCF46007.1 - 3e-34 116.5 2.6 3.3e-34 116.4 1.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e Dynamitin PF04912.9 CCF46008.1 - 0.0024 16.7 0.1 0.0024 16.7 0.0 1.0 1 0 0 1 1 1 1 Dynamitin FH2 PF02181.18 CCF46008.1 - 0.015 14.2 0.1 0.015 14.1 0.0 1.0 1 0 0 1 1 1 0 Formin Homology 2 Domain Methyltransf_33 PF10017.4 CCF46010.1 - 3.7e-21 75.3 0.0 6.7e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent Snf7 PF03357.16 CCF46013.1 - 2.5e-34 118.1 21.6 2.8e-34 117.9 15.0 1.0 1 0 0 1 1 1 1 Snf7 CaMBD PF02888.11 CCF46013.1 - 0.0015 18.2 4.0 0.0015 18.2 2.8 2.0 1 1 1 2 2 2 1 Calmodulin binding domain DUF4309 PF14172.1 CCF46013.1 - 0.036 14.0 0.1 0.065 13.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4309) Ist1 PF03398.9 CCF46013.1 - 0.074 12.4 6.7 0.15 11.4 4.6 1.6 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway DUF3576 PF12100.3 CCF46013.1 - 0.13 12.3 0.2 0.31 11.1 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3576) PspA_IM30 PF04012.7 CCF46013.1 - 0.28 10.5 17.1 0.94 8.7 2.9 2.1 1 1 0 2 2 2 0 PspA/IM30 family Hpt PF01627.18 CCF46013.1 - 2 8.4 4.9 7.9 6.5 0.5 2.6 1 1 1 2 2 2 0 Hpt domain LDB19 PF13002.2 CCF46016.1 - 2.6e-34 118.4 0.2 4.2e-34 117.7 0.2 1.2 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.24 CCF46016.1 - 2.4e-06 27.4 0.2 9.2e-06 25.5 0.0 2.1 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Fungal_trans_2 PF11951.3 CCF46017.1 - 9.4e-50 169.2 1.7 1.8e-49 168.3 1.2 1.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain Pam16 PF03656.8 CCF46018.1 - 9e-31 106.3 0.2 1.1e-30 106.0 0.1 1.0 1 0 0 1 1 1 1 Pam16 Beta_helix PF13229.1 CCF46019.1 - 5.3e-09 36.0 20.5 1.1e-06 28.4 12.5 2.7 2 1 0 2 2 2 1 Right handed beta helix region Chondroitinas_B PF14592.1 CCF46019.1 - 2.8e-06 26.4 0.4 8.7e-06 24.8 0.0 1.9 2 0 0 2 2 2 1 Chondroitinase B DUF1565 PF07602.6 CCF46019.1 - 0.00025 20.3 0.3 0.00025 20.3 0.2 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1565) CC2D2AN-C2 PF15625.1 CCF46019.1 - 0.1 12.0 1.5 0.22 10.9 0.5 1.8 2 0 0 2 2 2 0 CC2D2A N-terminal C2 domain Yip1 PF04893.12 CCF46020.1 - 4.5e-05 23.0 10.4 4.9e-05 22.8 6.1 1.8 1 1 1 2 2 2 1 Yip1 domain DUF3824 PF12868.2 CCF46020.1 - 1.6 9.6 5.9 2.6 8.9 4.1 1.4 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) RCC1 PF00415.13 CCF46021.1 - 4.4e-59 196.5 5.0 2.7e-10 40.2 0.0 7.8 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CCF46021.1 - 5.1e-37 124.7 28.8 1e-08 34.5 0.4 6.8 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat MIP-T3 PF10243.4 CCF46021.1 - 0.0011 17.5 44.0 0.0017 16.9 30.5 1.3 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 TFIIA PF03153.8 CCF46021.1 - 0.028 14.3 22.4 0.044 13.6 15.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ketoacyl-synt PF00109.21 CCF46022.1 - 8.7e-58 195.7 0.0 9.7e-58 195.6 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.18 CCF46022.1 - 0.055 12.4 0.0 0.085 11.8 0.0 1.3 1 0 0 1 1 1 0 Thiolase, N-terminal domain ADH_N PF08240.7 CCF46024.1 - 1e-05 25.2 0.0 7.7e-05 22.4 0.0 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain RNA_pol_3_Rpc31 PF11705.3 CCF46026.1 - 1e-22 81.2 0.0 1.1e-22 81.0 0.0 1.0 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 RRM_1 PF00076.17 CCF46028.1 - 1.7e-06 27.5 0.2 3.7e-06 26.4 0.1 1.6 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF46028.1 - 3.3e-05 23.6 0.1 5.3e-05 22.9 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF46028.1 - 3.5e-05 23.6 0.0 5.5e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) MNNL PF07657.8 CCF46030.1 - 0.085 12.8 2.3 10 6.1 0.0 2.5 3 0 0 3 3 3 0 N terminus of Notch ligand Fungal_trans PF04082.13 CCF46031.1 - 5.9e-27 94.1 2.1 1.1e-26 93.3 1.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sugarporin_N PF11471.3 CCF46031.1 - 0.27 10.9 2.6 0.62 9.7 1.8 1.6 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension ATAD4 PF15321.1 CCF46031.1 - 0.49 11.4 3.1 1.7 9.6 2.1 1.9 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 CDC45 PF02724.9 CCF46031.1 - 9.7 4.0 8.4 15 3.4 5.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Ctr PF04145.10 CCF46032.1 - 3.9e-41 140.4 2.2 4.6e-41 140.2 1.5 1.1 1 0 0 1 1 1 1 Ctr copper transporter family DUF4282 PF14110.1 CCF46032.1 - 0.17 12.0 5.1 0.14 12.3 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) Ferric_reduct PF01794.14 CCF46033.1 - 2.4e-21 76.0 8.4 2.4e-21 76.0 5.8 2.0 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.7 CCF46033.1 - 1.5e-14 54.2 0.0 2.3e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 CCF46033.1 - 4.5e-11 42.5 0.0 1.5e-10 40.8 0.0 1.8 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.16 CCF46033.1 - 0.00054 20.5 0.0 0.0011 19.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF1418 PF07214.7 CCF46033.1 - 4.4 6.9 6.0 5.8 6.6 0.0 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF1418) Tannase PF07519.6 CCF46036.1 - 0.096 11.3 0.0 0.098 11.3 0.0 1.0 1 0 0 1 1 1 0 Tannase and feruloyl esterase Calreticulin PF00262.13 CCF46037.1 - 1.2e-72 244.6 0.1 1.4e-72 244.4 0.1 1.0 1 0 0 1 1 1 1 Calreticulin family DUF1911 PF08929.5 CCF46037.1 - 0.026 15.2 0.1 0.045 14.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1911) LRR_6 PF13516.1 CCF46039.1 - 1.4e-18 64.7 0.3 0.00023 20.8 0.0 6.8 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.2 CCF46039.1 - 1.7e-07 30.6 0.0 0.26 10.9 0.0 4.9 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 CCF46039.1 - 5.7e-05 22.6 0.9 1.4 9.2 0.0 5.1 4 1 1 5 5 5 1 Leucine Rich Repeat LRR_7 PF13504.1 CCF46039.1 - 0.0065 16.4 1.4 7.7 7.2 0.0 5.1 6 0 0 6 6 6 1 Leucine rich repeat OMP_b-brl PF13505.1 CCF46041.1 - 0.014 15.3 8.1 0.024 14.5 5.6 1.5 1 1 0 1 1 1 0 Outer membrane protein beta-barrel domain SUR7 PF06687.7 CCF46042.1 - 5.6e-31 107.7 10.3 7.4e-31 107.3 7.1 1.1 1 0 0 1 1 1 1 SUR7/PalI family Claudin_2 PF13903.1 CCF46042.1 - 4e-07 29.8 7.1 4e-07 29.8 4.9 1.9 1 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction Trp_oprn_chp PF09534.5 CCF46042.1 - 0.0047 16.5 1.6 0.0047 16.5 1.1 1.5 2 0 0 2 2 2 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Amastin PF07344.6 CCF46042.1 - 0.77 9.3 15.9 0.46 10.0 9.6 1.6 2 0 0 2 2 2 0 Amastin surface glycoprotein PPR_3 PF13812.1 CCF46043.1 - 0.12 12.6 0.0 1.3 9.4 0.0 2.6 3 0 0 3 3 3 0 Pentatricopeptide repeat domain GFO_IDH_MocA PF01408.17 CCF46044.1 - 0.0003 21.2 0.5 0.0027 18.1 0.3 2.2 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold ATP_transf PF09830.4 CCF46045.1 - 1.7e-15 56.5 0.0 2.1e-15 56.2 0.0 1.1 1 0 0 1 1 1 1 ATP adenylyltransferase eIF-5_eIF-2B PF01873.12 CCF46047.1 - 5.5e-41 139.1 0.0 7.3e-41 138.7 0.0 1.2 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Zn-ribbon_8 PF09723.5 CCF46047.1 - 0.094 12.6 0.7 0.19 11.7 0.5 1.5 1 0 0 1 1 1 0 Zinc ribbon domain Utp21 PF04192.7 CCF46048.1 - 1.3e-80 269.9 0.0 1.8e-80 269.4 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.27 CCF46048.1 - 1.2e-20 72.5 19.8 1e-05 25.2 0.5 7.7 9 0 0 9 9 9 5 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 CCF46048.1 - 6e-05 21.5 0.0 0.00012 20.5 0.0 1.4 1 0 0 1 1 1 1 Cytochrome D1 heme domain Nup160 PF11715.3 CCF46048.1 - 0.0015 16.7 0.6 4.7 5.2 0.0 3.4 3 0 0 3 3 3 3 Nucleoporin Nup120/160 MFS_1 PF07690.11 CCF46049.1 - 1.3e-27 96.5 28.3 2.1e-27 95.7 19.4 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF3382 PF11862.3 CCF46049.1 - 0.0057 16.5 0.0 0.028 14.3 0.0 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3382) PUCC PF03209.10 CCF46049.1 - 0.035 12.8 8.6 0.045 12.4 4.7 1.9 2 1 0 2 2 2 0 PUCC protein DUF485 PF04341.7 CCF46049.1 - 0.42 10.3 0.0 0.42 10.3 0.0 3.1 4 0 0 4 4 4 0 Protein of unknown function, DUF485 Fungal_trans PF04082.13 CCF46050.1 - 7.3e-17 61.0 0.2 1.2e-16 60.4 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Nab6_mRNP_bdg PF10567.4 CCF46050.1 - 0.049 12.6 0.1 0.092 11.7 0.0 1.4 2 0 0 2 2 2 0 RNA-recognition motif DHH PF01368.15 CCF46051.1 - 3e-12 46.4 0.0 4.3e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 DHH family GATase PF00117.23 CCF46052.1 - 0.0014 18.1 0.0 0.0017 17.8 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Grp1_Fun34_YaaH PF01184.14 CCF46053.1 - 1.6e-49 168.1 9.2 2e-49 167.7 6.3 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Cyt-b5 PF00173.23 CCF46055.1 - 4e-12 45.7 0.0 5.6e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF2531 PF10748.4 CCF46055.1 - 0.11 11.6 0.0 0.22 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2531) Toxin_22 PF08092.6 CCF46055.1 - 0.16 11.7 1.8 0.34 10.7 1.2 1.5 1 0 0 1 1 1 0 Magi peptide toxin family TPP_enzyme_C PF02775.16 CCF46057.1 - 9.9e-24 83.6 0.2 1.5e-23 83.0 0.1 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Pkinase PF00069.20 CCF46059.1 - 5.8e-07 28.9 0.0 9.3e-07 28.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Dabb PF07876.7 CCF46060.1 - 1.6e-06 28.4 0.1 2.2e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain 3HCDH_N PF02737.13 CCF46060.1 - 0.075 12.6 0.1 0.09 12.4 0.1 1.1 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain RNase_H PF00075.19 CCF46062.1 - 2.9e-07 30.9 0.0 4.6e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 RNase H Mur_ligase_M PF08245.7 CCF46063.1 - 0.001 19.1 0.0 0.0069 16.4 0.0 2.0 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.16 CCF46063.1 - 0.018 15.0 0.0 0.038 14.0 0.0 1.5 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain DDE_1 PF03184.14 CCF46064.1 - 3.3e-20 72.1 0.0 6.3e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 CCF46064.1 - 0.015 15.0 0.2 0.04 13.6 0.0 1.7 2 0 0 2 2 2 0 DDE superfamily endonuclease DUF972 PF06156.8 CCF46064.1 - 0.058 13.7 0.2 0.1 12.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) ATP-synt_D PF01813.12 CCF46066.1 - 0.019 14.5 0.1 0.027 14.0 0.1 1.2 1 0 0 1 1 1 0 ATP synthase subunit D NEMO PF11577.3 CCF46066.1 - 1.5 8.6 4.5 1.7 8.4 1.2 2.1 2 1 0 2 2 2 0 NF-kappa-B essential modulator NEMO Phage_Coat_B PF05356.6 CCF46067.1 - 0.0029 17.2 1.6 0.0096 15.5 1.1 1.9 1 0 0 1 1 1 1 Phage Coat protein B STE PF02200.11 CCF46069.1 - 4.7e-62 206.9 0.4 9.3e-62 206.0 0.1 1.6 2 0 0 2 2 2 1 STE like transcription factor zf-C2H2 PF00096.21 CCF46069.1 - 5.2e-12 45.3 10.4 1.4e-06 28.2 0.6 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CCF46069.1 - 1.9e-08 34.1 3.1 1.9e-08 34.1 2.1 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 CCF46069.1 - 2.7e-07 30.4 9.1 3.2e-05 23.9 0.4 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 CCF46069.1 - 0.00051 19.8 0.1 0.00051 19.8 0.1 3.2 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CCF46069.1 - 0.045 13.8 0.2 0.045 13.8 0.2 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding FYDLN_acid PF09538.5 CCF46069.1 - 0.079 13.5 2.3 0.26 11.8 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DSBA PF01323.15 CCF46069.1 - 0.31 10.5 2.7 8.2 5.9 0.1 2.9 3 0 0 3 3 3 0 DSBA-like thioredoxin domain zf-C2HC_2 PF13913.1 CCF46069.1 - 0.89 9.2 3.2 3.8 7.2 0.1 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type HET PF06985.6 CCF46070.1 - 2.3e-22 79.6 6.4 2.9e-19 69.6 4.4 2.2 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) UBN2_3 PF14244.1 CCF46072.1 - 6.7e-05 22.4 0.0 0.00035 20.1 0.0 2.0 2 1 1 3 3 3 1 gag-polypeptide of LTR copia-type MIR PF02815.14 CCF46073.1 - 1.1e-39 136.0 0.6 1.4e-39 135.6 0.4 1.1 1 0 0 1 1 1 1 MIR domain PMT PF02366.13 CCF46073.1 - 2.5e-16 59.7 4.6 2.5e-16 59.7 3.2 2.7 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Glyco_hydro_43 PF04616.9 CCF46074.1 - 6.8e-11 41.7 2.4 1.8e-10 40.3 1.7 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 Isochorismatase PF00857.15 CCF46075.1 - 6.6e-20 71.7 0.0 8.3e-20 71.4 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family TrbH PF07283.6 CCF46075.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Conjugal transfer protein TrbH Cyt-b5 PF00173.23 CCF46078.1 - 6e-14 51.5 0.0 2.1e-13 49.8 0.0 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain IDO PF01231.13 CCF46078.1 - 2e-11 42.9 0.0 2.3e-10 39.4 0.0 2.3 3 0 0 3 3 3 1 Indoleamine 2,3-dioxygenase FAD_binding_1 PF00667.15 CCF46078.1 - 6.5e-11 42.1 0.0 2.6e-10 40.1 0.0 2.0 2 1 0 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.16 CCF46078.1 - 1.7e-09 38.1 0.0 6.5e-09 36.3 0.0 2.0 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Tannase PF07519.6 CCF46081.1 - 6.2e-26 91.1 0.3 8.9e-26 90.6 0.2 1.2 1 0 0 1 1 1 1 Tannase and feruloyl esterase Thiolase_C PF02803.13 CCF46082.1 - 1.6e-10 40.4 0.3 5.8e-10 38.6 0.0 2.0 2 0 0 2 2 2 1 Thiolase, C-terminal domain ACP_syn_III PF08545.5 CCF46082.1 - 5.7e-08 32.3 0.3 3.8e-06 26.4 0.1 2.4 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.21 CCF46082.1 - 6.2e-05 22.5 0.0 0.00013 21.5 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.18 CCF46082.1 - 0.00057 18.9 0.9 0.0013 17.8 0.0 2.1 3 0 0 3 3 3 1 Thiolase, N-terminal domain Ketoacyl-synt_C PF02801.17 CCF46082.1 - 0.0034 17.2 0.6 0.022 14.5 0.0 2.4 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain SpoVAD PF07451.6 CCF46082.1 - 0.026 13.0 0.3 0.077 11.4 0.1 1.7 2 0 0 2 2 2 0 Stage V sporulation protein AD (SpoVAD) Dendrin PF15498.1 CCF46083.1 - 0.026 13.0 1.4 0.027 12.9 0.9 1.0 1 0 0 1 1 1 0 Nephrin and CD2AP-binding protein, Dendrin X8 PF07983.8 CCF46084.1 - 1.3e-23 83.2 3.0 3e-23 82.0 2.1 1.6 1 0 0 1 1 1 1 X8 domain DUF2076 PF09849.4 CCF46084.1 - 0.73 9.8 5.4 1 9.3 3.8 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Zn_clus PF00172.13 CCF46086.1 - 4.1e-10 39.3 8.5 7.6e-10 38.5 5.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1675 PF07897.6 CCF46086.1 - 0.016 15.1 15.7 0.021 14.6 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Fungal_trans_2 PF11951.3 CCF46086.1 - 0.11 11.0 0.0 0.19 10.3 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain IF-2B PF01008.12 CCF46088.1 - 1.3e-45 155.5 0.0 3.6e-45 154.1 0.0 1.6 1 1 0 1 1 1 1 Initiation factor 2 subunit family Usp PF00582.21 CCF46088.1 - 1.3 9.2 4.3 2.7 8.1 0.0 2.5 2 0 0 2 2 2 0 Universal stress protein family IF3_C PF00707.17 CCF46089.1 - 3.9e-10 39.3 0.1 7.5e-10 38.4 0.1 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain mIF3 PF14877.1 CCF46089.1 - 5.7e-06 25.8 0.2 5.3e-05 22.6 0.1 2.0 1 1 1 2 2 2 1 Mitochondrial translation initiation factor IF3_N PF05198.11 CCF46089.1 - 0.0051 16.7 0.2 0.014 15.3 0.1 1.7 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain Peptidase_S24 PF00717.18 CCF46090.1 - 5.9e-08 32.2 0.1 9.1e-08 31.6 0.1 1.3 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.4 CCF46090.1 - 1e-06 28.3 0.0 4.5e-05 22.9 0.0 2.5 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 Arm PF00514.18 CCF46091.1 - 6e-71 232.0 33.6 3.4e-13 48.8 0.1 11.1 11 1 0 11 11 11 9 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 CCF46091.1 - 2.8e-23 82.0 15.7 2.9e-06 27.4 0.5 7.8 2 2 3 6 6 6 6 HEAT repeats HEAT PF02985.17 CCF46091.1 - 1e-18 65.6 16.3 0.046 13.8 0.1 9.7 11 0 0 11 11 10 5 HEAT repeat HEAT_EZ PF13513.1 CCF46091.1 - 4.2e-15 55.7 13.1 0.011 16.2 0.2 8.4 5 1 3 9 9 9 5 HEAT-like repeat Adaptin_N PF01602.15 CCF46091.1 - 6.6e-11 41.2 11.0 2.1e-07 29.6 0.3 3.0 1 1 2 3 3 3 2 Adaptin N terminal region Arm_2 PF04826.8 CCF46091.1 - 1e-10 41.1 12.2 0.00026 20.1 0.9 3.5 3 1 1 4 4 4 3 Armadillo-like KAP PF05804.7 CCF46091.1 - 2.1e-09 35.9 0.7 4.2e-09 34.9 0.5 1.5 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.9 CCF46091.1 - 2.4e-09 36.7 2.2 0.0013 17.8 0.6 3.8 2 1 1 3 3 3 2 V-ATPase subunit H DUF2454 PF10521.4 CCF46091.1 - 0.0011 18.0 0.7 0.012 14.6 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2454) HEAT_PBS PF03130.11 CCF46091.1 - 0.02 15.3 8.1 34 5.3 0.2 6.9 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat Vac14_Fab1_bd PF12755.2 CCF46091.1 - 0.022 15.1 0.1 1.7 9.0 0.1 3.3 2 1 2 4 4 4 0 Vacuolar 14 Fab1-binding region RIX1 PF08167.7 CCF46091.1 - 0.052 13.2 1.8 0.24 11.0 0.3 2.8 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis DLH PF01738.13 CCF46092.1 - 5.5e-06 25.8 0.0 6.2e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family TRI5 PF06330.6 CCF46093.1 - 1.2e-11 43.8 0.0 1.6e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) DUF4184 PF13803.1 CCF46094.1 - 0.0071 15.6 0.1 1.5 8.0 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4184) Corona_S2 PF01601.11 CCF46094.1 - 0.041 11.9 0.3 0.056 11.5 0.2 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein DUF1673 PF07895.6 CCF46094.1 - 0.094 12.2 0.6 0.18 11.3 0.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1673) Tetraspannin PF00335.15 CCF46094.1 - 0.2 10.9 0.0 0.2 10.9 0.0 1.8 2 0 0 2 2 2 0 Tetraspanin family DUF4117 PF13491.1 CCF46094.1 - 0.53 9.7 5.7 1.5 8.2 3.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4117) FA_desaturase PF00487.19 CCF46094.1 - 4.4 6.6 9.2 0.19 11.1 1.9 1.9 2 0 0 2 2 2 0 Fatty acid desaturase PQ-loop PF04193.9 CCF46094.1 - 7.8 6.1 7.2 6.3 6.4 0.1 2.9 3 0 0 3 3 3 0 PQ loop repeat FixP_N PF14715.1 CCF46094.1 - 8.4 5.8 7.7 8.9 5.7 1.1 2.7 2 0 0 2 2 2 0 N-terminal domain of cytochrome oxidase-cbb3, FixP L31 PF09784.4 CCF46095.1 - 4.8e-46 155.0 1.8 5.3e-46 154.9 1.2 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 Sedlin_N PF04628.8 CCF46096.1 - 1.4e-11 44.4 0.0 1.4e-11 44.3 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region DUF952 PF06108.7 CCF46097.1 - 2.3e-08 33.7 0.0 2.6e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF952) UCH PF00443.24 CCF46098.1 - 8.2e-26 90.6 0.0 2.6e-25 89.0 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CCF46098.1 - 4.5e-08 32.8 0.0 5.9e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RRM_1 PF00076.17 CCF46099.1 - 1.2e-09 37.5 0.0 1.8e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF46099.1 - 1.4e-08 34.6 0.0 1.9e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF46099.1 - 0.0024 17.6 0.0 0.0046 16.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAD_binding_7 PF03441.9 CCF46101.1 - 3.5e-56 190.4 0.1 5e-56 189.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.13 CCF46101.1 - 1.8e-21 76.5 0.0 3e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 DNA photolyase Herpes_capsid PF06112.6 CCF46101.1 - 8.9 6.3 6.4 17 5.4 4.4 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein 4HBT PF03061.17 CCF46102.1 - 3.2e-05 23.9 0.1 6.8e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 Thioesterase superfamily SQS_PSY PF00494.14 CCF46103.1 - 2.2e-66 223.8 1.2 2.7e-66 223.5 0.9 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase His_Phos_2 PF00328.17 CCF46104.1 - 1.5e-24 87.0 0.0 1.9e-24 86.6 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) His_Phos_1 PF00300.17 CCF46104.1 - 0.012 15.6 0.0 0.019 15.0 0.0 1.3 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) 4HBT_2 PF13279.1 CCF46105.1 - 3.2e-07 30.8 0.0 4.7e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily DBR1 PF05011.8 CCF46105.1 - 0.00073 19.4 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain adh_short PF00106.20 CCF46106.1 - 4.4e-14 52.7 0.0 6e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF46106.1 - 4.1e-09 36.5 0.0 5.4e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF46106.1 - 5.7e-08 32.6 0.1 9.7e-08 31.8 0.0 1.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF46106.1 - 0.015 14.7 0.0 0.2 11.0 0.0 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF46106.1 - 0.065 13.2 1.5 0.84 9.6 1.0 2.4 1 1 0 1 1 1 0 NADH(P)-binding Glyco_hydro_43 PF04616.9 CCF46108.1 - 1.3e-76 257.4 0.6 1.9e-76 256.8 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 MAPEG PF01124.13 CCF46109.1 - 5.4e-12 45.4 3.8 5.9e-12 45.3 2.6 1.0 1 0 0 1 1 1 1 MAPEG family TauD PF02668.11 CCF46110.1 - 2.8e-26 92.7 0.0 3.8e-26 92.3 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family RhoGAP PF00620.22 CCF46110.1 - 0.018 14.6 0.0 0.029 13.9 0.0 1.3 1 0 0 1 1 1 0 RhoGAP domain AA_permease_2 PF13520.1 CCF46111.1 - 6.9e-75 252.1 35.9 8.6e-75 251.8 24.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF46111.1 - 3.8e-22 78.2 35.6 5.1e-22 77.8 24.6 1.1 1 0 0 1 1 1 1 Amino acid permease HTH_Tnp_Tc5 PF03221.11 CCF46112.1 - 2.7e-13 49.5 0.5 6.1e-13 48.3 0.0 1.9 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF46112.1 - 5.7e-12 44.9 0.1 1.1e-11 44.0 0.1 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_1 PF03184.14 CCF46112.1 - 0.00013 21.1 0.0 0.00025 20.2 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_28 PF13518.1 CCF46112.1 - 0.00086 19.2 0.2 0.0032 17.4 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 CCF46112.1 - 0.00088 18.8 0.4 0.0028 17.2 0.0 2.1 3 0 0 3 3 3 1 Homeodomain-like domain CENP-B_N PF04218.8 CCF46112.1 - 0.014 14.8 0.0 0.029 13.7 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_29 PF13551.1 CCF46112.1 - 0.076 13.1 1.5 0.23 11.5 0.5 2.2 1 1 1 2 2 2 0 Winged helix-turn helix p450 PF00067.17 CCF46113.1 - 5.3e-41 140.6 0.0 1.3e-39 135.9 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 NAD_binding_8 PF13450.1 CCF46114.1 - 2.3e-06 27.5 0.0 2.7e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CCF46114.1 - 0.0043 17.1 0.0 0.0043 17.1 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF46114.1 - 0.015 14.4 0.0 0.018 14.1 0.0 1.1 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.9 CCF46114.1 - 0.018 14.9 0.0 0.018 14.9 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF46114.1 - 0.042 13.6 0.0 0.042 13.6 0.0 1.3 1 1 0 1 1 1 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.19 CCF46114.1 - 0.1 11.4 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.16 CCF46114.1 - 0.12 11.9 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thg1C PF14413.1 CCF46116.1 - 3.6e-26 91.2 0.0 5.1e-26 90.7 0.0 1.2 1 0 0 1 1 1 1 Thg1 C terminal domain Thg1 PF04446.7 CCF46116.1 - 1e-21 77.0 0.0 1.4e-21 76.5 0.0 1.2 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Cu-oxidase_3 PF07732.10 CCF46117.1 - 5.4e-20 71.2 0.0 1.1e-19 70.3 0.0 1.5 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase PF00394.17 CCF46117.1 - 0.00082 19.2 0.0 0.0019 18.1 0.0 1.7 1 1 0 1 1 1 1 Multicopper oxidase IBR PF01485.16 CCF46118.1 - 3.7e-10 39.5 0.5 3.7e-10 39.5 0.4 2.7 2 1 0 2 2 2 1 IBR domain zf-C3HC4_3 PF13920.1 CCF46118.1 - 0.29 10.8 11.1 0.055 13.1 3.7 2.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CCF46118.1 - 4 7.5 15.5 0.074 13.0 4.4 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TerY-C PF15616.1 CCF46118.1 - 4.4 7.2 9.2 1.3 8.9 0.4 2.9 2 1 0 2 2 2 0 TerY-C metal binding domain zf-RING_4 PF14570.1 CCF46118.1 - 9.3 5.9 9.9 2.4 7.7 3.7 2.4 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain U3snoRNP10 PF12397.3 CCF46119.1 - 6.4e-26 90.6 2.7 3.7e-24 84.9 0.1 4.1 3 0 0 3 3 3 1 U3 small nucleolar RNA-associated protein 10 HEAT PF02985.17 CCF46119.1 - 0.00013 21.7 1.7 0.0082 16.1 0.0 3.9 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.1 CCF46119.1 - 0.028 14.6 0.1 0.028 14.6 0.1 5.2 5 2 0 5 5 5 0 HEAT repeats HEAT_EZ PF13513.1 CCF46119.1 - 0.16 12.4 13.2 0.045 14.2 1.4 5.1 6 1 1 7 7 7 0 HEAT-like repeat DUF2360 PF10152.4 CCF46119.1 - 0.2 11.9 2.1 0.57 10.4 0.2 2.4 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) Lipase_GDSL_2 PF13472.1 CCF46120.1 - 1.6e-19 70.6 0.0 2e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 CCF46120.1 - 7.2e-16 58.7 0.0 8.9e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.1 CCF46120.1 - 0.17 11.6 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family FAD_binding_2 PF00890.19 CCF46122.1 - 2.3e-46 158.4 0.5 2.6e-46 158.3 0.3 1.0 1 0 0 1 1 1 1 FAD binding domain Baculo_ME53 PF06061.6 CCF46124.1 - 0.031 13.2 0.4 0.034 13.1 0.3 1.0 1 0 0 1 1 1 0 Baculoviridae ME53 RNB PF00773.14 CCF46125.1 - 7e-19 68.2 0.0 1.2e-18 67.5 0.0 1.4 1 0 0 1 1 1 1 RNB domain PIN_4 PF13638.1 CCF46125.1 - 1.6e-11 44.4 0.4 5.2e-11 42.7 0.3 1.9 1 1 0 1 1 1 1 PIN domain Ank_2 PF12796.2 CCF46126.1 - 2.2e-17 63.1 0.1 4.8e-17 62.0 0.1 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CCF46126.1 - 6.5e-17 61.5 2.0 1.6e-08 34.7 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 CCF46126.1 - 1.7e-16 59.0 1.5 1.4e-08 34.0 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 CCF46126.1 - 3.2e-16 58.9 7.7 9.9e-08 31.9 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF46126.1 - 1.2e-12 46.6 0.1 2.5e-05 24.0 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Pkinase PF00069.20 CCF46127.1 - 9.1e-54 182.3 0.0 1.1e-53 182.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF46127.1 - 1.6e-34 119.1 0.0 2.1e-34 118.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF46127.1 - 3.8e-07 29.3 0.0 5.4e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Kinase-like TauD PF02668.11 CCF46128.1 - 1.5e-55 188.6 0.5 1.9e-55 188.3 0.3 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family AAA PF00004.24 CCF46130.1 - 2.2e-06 27.8 0.2 1.1e-05 25.6 0.2 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) OTT_1508_deam PF14441.1 CCF46131.1 - 3.9e-11 42.9 0.0 6.4e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 OTT_1508-like deaminase Abhydrolase_6 PF12697.2 CCF46133.1 - 6.8e-11 42.4 0.0 1.1e-10 41.7 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF46133.1 - 7.8e-07 28.9 0.2 2.4e-06 27.3 0.2 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Aldo_ket_red PF00248.16 CCF46136.1 - 2.3e-39 134.9 0.0 2.7e-39 134.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Glyco_transf_28 PF03033.15 CCF46138.1 - 2.6e-21 75.8 0.0 7.1e-21 74.4 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase family 28 N-terminal domain GMC_oxred_C PF05199.8 CCF46140.1 - 3e-27 95.6 0.0 3.5e-27 95.4 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase DUF1469 PF07332.6 CCF46142.1 - 0.026 14.2 0.4 0.026 14.2 0.3 4.2 5 0 0 5 5 5 0 Protein of unknown function (DUF1469) AAR2 PF05282.6 CCF46142.1 - 0.052 12.4 0.5 0.15 10.9 0.4 1.7 1 0 0 1 1 1 0 AAR2 protein Exo_endo_phos PF03372.18 CCF46143.1 - 0.00087 19.2 2.1 0.0038 17.1 1.4 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HATPase_c PF02518.21 CCF46145.1 - 2.9e-22 78.4 0.2 6.3e-22 77.4 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 CCF46145.1 - 0.084 12.6 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain RRM_1 PF00076.17 CCF46147.1 - 4.1e-18 64.7 0.1 7.3e-18 63.9 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF46147.1 - 2.2e-13 49.9 0.0 3.6e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF46147.1 - 6.2e-09 35.5 0.1 8.6e-09 35.1 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GRAM PF02893.15 CCF46148.1 - 0.025 14.0 0.0 0.059 12.9 0.0 1.6 1 0 0 1 1 1 0 GRAM domain Flavi_NS2A PF01005.14 CCF46148.1 - 0.16 11.1 3.7 0.26 10.5 2.6 1.2 1 0 0 1 1 1 0 Flavivirus non-structural protein NS2A Aldedh PF00171.17 CCF46149.1 - 2.1e-143 478.0 0.0 2.7e-143 477.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 CCF46149.1 - 0.0063 15.2 0.0 0.012 14.4 0.0 1.5 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) Cu-oxidase_3 PF07732.10 CCF46150.1 - 6.9e-44 148.3 2.8 1.1e-43 147.7 1.9 1.3 1 0 0 1 1 1 1 Multicopper oxidase Exo_endo_phos PF03372.18 CCF46151.1 - 6.6e-10 39.3 2.7 4.8e-09 36.5 1.9 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family U-box PF04564.10 CCF46152.1 - 0.01 15.8 0.0 0.01 15.8 0.0 1.1 1 0 0 1 1 1 1 U-box domain U3_assoc_6 PF08640.6 CCF46153.1 - 2.1e-27 94.6 0.3 2.3e-27 94.5 0.2 1.0 1 0 0 1 1 1 1 U3 small nucleolar RNA-associated protein 6 Frag1 PF10277.4 CCF46154.1 - 1.1e-14 54.4 0.2 1.3e-14 54.1 0.2 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family NfeD PF01957.13 CCF46155.1 - 0.12 12.5 0.0 0.38 10.8 0.0 1.8 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding Sugar_tr PF00083.19 CCF46155.1 - 0.67 8.4 4.7 0.83 8.1 3.3 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter ABC_membrane PF00664.18 CCF46156.1 - 3.8e-45 154.4 10.6 5.4e-45 153.9 7.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 CCF46156.1 - 6.1e-42 143.1 0.0 7.8e-29 100.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 CCF46156.1 - 9.8e-11 41.2 1.8 0.00091 18.5 0.1 3.1 2 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CCF46156.1 - 7.6e-09 35.9 0.0 0.011 15.6 0.0 3.2 2 1 1 3 3 3 2 AAA domain SbcCD_C PF13558.1 CCF46156.1 - 1.1e-05 25.2 4.5 0.16 11.8 0.1 4.0 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.1 CCF46156.1 - 3.5e-05 23.8 0.1 0.0085 16.0 0.0 3.3 2 1 0 2 2 2 1 AAA ATPase domain ABC_ATPase PF09818.4 CCF46156.1 - 0.00014 20.6 0.3 0.0035 16.0 0.0 2.6 3 0 0 3 3 3 1 Predicted ATPase of the ABC class AAA PF00004.24 CCF46156.1 - 0.00054 20.1 1.8 0.15 12.2 0.2 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 CCF46156.1 - 0.0014 18.3 2.6 0.62 9.8 0.0 3.1 3 0 0 3 3 3 2 Part of AAA domain AAA_25 PF13481.1 CCF46156.1 - 0.0016 17.8 0.2 0.56 9.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.1 CCF46156.1 - 0.0022 18.1 0.4 0.15 12.2 0.1 3.1 2 1 0 2 2 2 1 AAA domain DUF258 PF03193.11 CCF46156.1 - 0.0026 16.9 0.2 0.0072 15.5 0.0 1.9 2 1 0 2 2 2 1 Protein of unknown function, DUF258 AAA_17 PF13207.1 CCF46156.1 - 0.0028 18.4 0.0 0.0073 17.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain ATP-synt_ab PF00006.20 CCF46156.1 - 0.03 13.8 0.4 1.5 8.2 0.0 2.6 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_5 PF07728.9 CCF46156.1 - 0.081 12.6 0.1 1.9 8.1 0.0 2.8 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 CCF46156.1 - 0.13 12.5 0.0 0.34 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 CCF46156.1 - 0.14 12.1 0.0 9.3 6.1 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_10 PF12846.2 CCF46156.1 - 0.17 11.2 1.2 19 4.5 0.0 3.0 3 0 0 3 3 3 0 AAA-like domain Zn_clus PF00172.13 CCF46157.1 - 1e-08 34.9 10.3 1.7e-08 34.2 7.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_17 PF00332.13 CCF46158.1 - 0.00074 18.6 0.7 0.0019 17.3 0.5 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 UDPG_MGDP_dh_N PF03721.9 CCF46159.1 - 2.8e-22 79.0 0.0 1e-19 70.6 0.0 2.2 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.14 CCF46159.1 - 6.5e-18 64.7 0.0 2e-17 63.2 0.0 1.8 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain NAD_binding_2 PF03446.10 CCF46159.1 - 3.5e-07 30.1 0.0 6.1e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_C PF03720.10 CCF46159.1 - 0.0024 17.9 0.0 0.0047 17.0 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Methyltransf_18 PF12847.2 CCF46159.1 - 0.012 16.1 0.0 0.43 11.1 0.0 2.6 2 1 0 2 2 2 0 Methyltransferase domain F420_oxidored PF03807.12 CCF46159.1 - 0.11 12.8 0.0 0.38 11.1 0.0 1.9 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Methyltransf_31 PF13847.1 CCF46159.1 - 0.14 11.7 0.0 2.1 7.8 0.0 2.5 2 1 0 2 2 2 0 Methyltransferase domain TrkA_N PF02254.13 CCF46159.1 - 0.16 11.9 0.0 0.34 10.9 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain ABC_tran PF00005.22 CCF46161.1 - 2.3e-12 47.3 0.0 6.2e-12 45.9 0.0 1.6 2 0 0 2 2 2 1 ABC transporter ABC_trans_N PF14510.1 CCF46161.1 - 9.3e-06 25.6 0.0 2e-05 24.5 0.0 1.5 1 1 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_22 PF13401.1 CCF46161.1 - 0.0057 16.8 0.0 0.01 15.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.13 CCF46161.1 - 0.037 13.5 0.0 0.089 12.2 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_19 PF13245.1 CCF46161.1 - 0.084 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain AAA_29 PF13555.1 CCF46161.1 - 0.093 12.2 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Arch_ATPase PF01637.13 CCF46161.1 - 0.13 11.9 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase Peptidase_S8 PF00082.17 CCF46165.1 - 1.5e-27 96.5 0.3 2e-27 96.1 0.2 1.1 1 0 0 1 1 1 1 Subtilase family Peptidase_S68 PF10461.4 CCF46166.1 - 0.14 11.9 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Peptidase S68 Peptidase_S9 PF00326.16 CCF46167.1 - 1.4e-47 161.6 0.0 2.4e-47 160.9 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CCF46167.1 - 5.7e-10 39.1 0.0 1.6e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.7 CCF46167.1 - 0.0012 17.4 0.0 0.36 9.2 0.0 2.4 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) PD40 PF07676.7 CCF46167.1 - 0.1 12.2 0.8 4.7 6.9 0.0 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Glyco_hydro_2 PF00703.16 CCF46168.1 - 1.4e-10 41.6 0.0 2.9e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.13 CCF46168.1 - 1.2e-07 31.4 0.0 2.2e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.12 CCF46168.1 - 2.2e-05 23.5 0.0 3.7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain MFS_1 PF07690.11 CCF46169.1 - 1.3e-28 99.7 26.1 1.6e-28 99.4 18.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1616 PF07760.6 CCF46169.1 - 0.019 14.1 2.6 0.034 13.2 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) Zn_clus PF00172.13 CCF46170.1 - 3.4e-09 36.4 9.6 5e-09 35.9 6.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2796 PF10986.3 CCF46170.1 - 0.049 13.6 8.9 0.06 13.3 6.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) CPSF73-100_C PF11718.3 CCF46170.1 - 0.086 12.1 0.6 0.081 12.2 0.4 1.1 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term CDC45 PF02724.9 CCF46170.1 - 0.12 10.4 1.9 0.11 10.5 1.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Macoilin PF09726.4 CCF46170.1 - 0.17 10.1 3.8 0.18 10.0 2.6 1.0 1 0 0 1 1 1 0 Transmembrane protein Zip PF02535.17 CCF46170.1 - 0.2 10.6 4.3 0.2 10.6 3.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SelP_N PF04592.9 CCF46170.1 - 1.3 8.3 13.7 0.059 12.7 5.9 1.4 2 0 0 2 2 2 0 Selenoprotein P, N terminal region DUF4611 PF15387.1 CCF46170.1 - 8.2 6.6 7.0 14 5.8 4.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4611) DUF658 PF04936.7 CCF46172.1 - 0.085 12.7 0.6 0.11 12.2 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF658) STAG PF08514.6 CCF46172.1 - 0.26 10.9 0.9 0.36 10.5 0.6 1.1 1 0 0 1 1 1 0 STAG domain MOSC_N PF03476.11 CCF46173.1 - 2.7e-23 81.9 0.0 5e-23 81.0 0.0 1.5 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.12 CCF46173.1 - 4.6e-23 81.1 0.0 8.4e-23 80.3 0.0 1.4 1 0 0 1 1 1 1 MOSC domain YidC_periplas PF14849.1 CCF46174.1 - 0.011 15.7 0.2 0.013 15.4 0.1 1.1 1 0 0 1 1 1 0 YidC periplasmic domain MgtE_N PF03448.12 CCF46174.1 - 0.019 15.2 0.2 0.033 14.5 0.1 1.4 1 0 0 1 1 1 0 MgtE intracellular N domain DUF3791 PF12668.2 CCF46174.1 - 0.043 13.4 0.1 0.27 10.8 0.0 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3791) p25-alpha PF05517.7 CCF46174.1 - 0.1 12.8 0.3 0.21 11.8 0.2 1.6 1 1 1 2 2 2 0 p25-alpha UTP15_C PF09384.5 CCF46174.1 - 0.13 11.9 0.3 0.27 10.9 0.1 1.6 2 0 0 2 2 2 0 UTP15 C terminal EFG_II PF14492.1 CCF46174.1 - 0.19 11.5 0.5 0.52 10.1 0.1 2.0 2 1 0 2 2 2 0 Elongation Factor G, domain II p450 PF00067.17 CCF46176.1 - 1.8e-32 112.4 0.0 2.4e-32 112.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Mpv17_PMP22 PF04117.7 CCF46178.1 - 2.9e-12 46.0 0.4 2.9e-12 46.0 0.3 2.3 2 0 0 2 2 2 1 Mpv17 / PMP22 family Methyltransf_15 PF09445.5 CCF46178.1 - 0.061 12.8 0.0 0.084 12.4 0.0 1.1 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase HATPase_c PF02518.21 CCF46179.1 - 1.1e-21 76.6 0.0 2.4e-21 75.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.1 CCF46179.1 - 1.2e-19 70.5 1.0 3.1e-06 27.5 0.2 4.0 3 1 0 3 3 3 3 PAS domain Response_reg PF00072.19 CCF46179.1 - 2.2e-17 63.0 0.4 1.3e-16 60.5 0.0 2.5 2 1 0 2 2 2 1 Response regulator receiver domain PAS_4 PF08448.5 CCF46179.1 - 2.6e-15 56.4 0.2 0.00069 19.6 0.0 4.7 3 1 0 3 3 3 3 PAS fold PAS PF00989.19 CCF46179.1 - 1.1e-12 47.7 0.0 0.0012 18.6 0.0 3.9 3 0 0 3 3 3 3 PAS fold PAS_3 PF08447.6 CCF46179.1 - 2.7e-08 33.8 0.3 0.00016 21.7 0.0 3.7 3 1 0 3 3 3 2 PAS fold HisKA PF00512.20 CCF46179.1 - 9.9e-08 31.8 0.0 5.2e-07 29.5 0.0 2.4 1 1 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.1 CCF46179.1 - 3.5e-06 26.6 0.0 0.046 13.5 0.0 3.3 3 0 0 3 3 3 2 PAS domain GAF_2 PF13185.1 CCF46179.1 - 9.7e-05 22.8 0.0 0.011 16.2 0.0 2.8 2 0 0 2 2 2 1 GAF domain GAF_3 PF13492.1 CCF46179.1 - 0.00011 22.2 0.0 0.0055 16.7 0.0 2.7 2 0 0 2 2 2 1 GAF domain PAS_7 PF12860.2 CCF46179.1 - 0.068 13.1 2.7 0.31 11.0 0.1 3.3 3 1 0 3 3 2 0 PAS fold CFEM PF05730.6 CCF46180.1 - 2.3e-10 40.1 11.7 5.8e-10 38.8 8.1 1.7 1 1 0 1 1 1 1 CFEM domain Med3 PF11593.3 CCF46180.1 - 0.5 9.5 6.0 0.63 9.2 4.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal WD40 PF00400.27 CCF46181.1 - 4.2e-27 93.0 16.9 3.1e-08 33.1 0.0 7.3 6 1 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.6 CCF46181.1 - 1.6e-06 27.9 0.0 0.027 14.1 0.0 3.0 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.11 CCF46181.1 - 0.0067 14.7 0.0 2.1 6.5 0.0 3.6 2 1 2 4 4 4 1 Cytochrome D1 heme domain ABC_tran PF00005.22 CCF46182.1 - 4.2e-22 78.9 0.0 6.6e-22 78.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.19 CCF46182.1 - 5.9e-18 64.8 9.5 9e-18 64.1 6.6 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 CCF46182.1 - 2.4e-06 26.8 13.9 3.3e-06 26.3 9.7 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein DUF258 PF03193.11 CCF46182.1 - 0.014 14.6 0.5 0.035 13.3 0.5 1.5 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_21 PF13304.1 CCF46182.1 - 0.019 14.9 0.0 0.13 12.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 CCF46182.1 - 0.026 14.4 0.0 0.062 13.2 0.0 1.7 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit YqzM PF14141.1 CCF46182.1 - 3.5 7.5 4.9 0.65 9.8 0.2 2.2 2 0 0 2 2 2 0 YqzM-like protein ATP-synt_DE PF00401.15 CCF46183.1 - 0.0053 16.6 1.3 0.0073 16.1 0.9 1.4 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, long alpha-helix domain PHTB1_C PF14728.1 CCF46183.1 - 0.014 14.1 0.1 0.015 14.1 0.1 1.0 1 0 0 1 1 1 0 PTHB1 C-terminus UPF0449 PF15136.1 CCF46183.1 - 0.068 13.3 1.1 0.12 12.5 0.8 1.5 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 DMPK_coil PF08826.5 CCF46183.1 - 0.17 11.7 3.6 0.23 11.3 2.5 1.2 1 0 0 1 1 1 0 DMPK coiled coil domain like PTR2 PF00854.16 CCF46184.1 - 1.4e-30 106.3 4.0 6.6e-16 58.0 1.5 2.2 2 0 0 2 2 2 2 POT family HlyIII PF03006.15 CCF46184.1 - 0.03 13.7 13.8 0.084 12.2 1.3 3.1 1 1 1 2 2 2 0 Haemolysin-III related DUF1469 PF07332.6 CCF46184.1 - 0.15 11.8 4.1 0.74 9.5 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) Bax1-I PF01027.15 CCF46184.1 - 0.16 11.5 14.5 0.54 9.8 6.3 2.5 2 1 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 RseC_MucC PF04246.7 CCF46184.1 - 0.73 9.3 6.0 0.46 10.0 0.1 3.0 3 1 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC Mitofilin PF09731.4 CCF46188.1 - 0.015 13.9 23.0 0.02 13.6 15.9 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Borrelia_P83 PF05262.6 CCF46188.1 - 0.036 12.3 30.9 0.041 12.1 21.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Daxx PF03344.10 CCF46188.1 - 0.7 8.3 29.2 0.8 8.1 20.3 1.1 1 0 0 1 1 1 0 Daxx Family Asp-B-Hydro_N PF05279.6 CCF46188.1 - 0.73 9.6 25.6 0.95 9.2 17.7 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF1509 PF07420.6 CCF46188.1 - 2.2 7.4 5.5 2.6 7.2 3.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) MIP-T3 PF10243.4 CCF46188.1 - 2.5 6.4 39.5 3.3 6.0 27.4 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF966 PF06136.8 CCF46188.1 - 2.5 7.4 13.2 2.9 7.2 9.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Pilt PF15453.1 CCF46188.1 - 3.7 7.1 20.2 4.7 6.7 14.0 1.2 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions Ycf1 PF05758.7 CCF46188.1 - 4.9 4.7 17.4 5.6 4.5 12.0 1.1 1 0 0 1 1 1 0 Ycf1 CDC27 PF09507.5 CCF46188.1 - 7.3 5.6 32.2 9.5 5.3 22.3 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 WBS_methylT PF12589.3 CCF46189.1 - 3.3e-17 62.7 7.0 6.2e-17 61.8 4.9 1.5 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.7 CCF46189.1 - 1.9e-11 44.3 0.0 4.1e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF46189.1 - 1.1e-07 32.1 0.0 2.3e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF46189.1 - 9.3e-06 25.6 0.0 1.7e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF46189.1 - 1.4e-05 24.7 0.0 2.1e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF46189.1 - 1.4e-05 25.4 0.0 4.9e-05 23.7 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF46189.1 - 7.6e-05 22.4 0.0 0.00011 21.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF46189.1 - 0.00011 22.8 0.0 0.00029 21.3 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain PCMT PF01135.14 CCF46189.1 - 0.00024 20.6 0.0 0.00041 19.9 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.15 CCF46189.1 - 0.0038 16.3 0.0 0.088 11.8 0.0 2.1 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 CCF46189.1 - 0.034 13.2 0.0 0.11 11.5 0.0 1.8 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Erv26 PF04148.8 CCF46190.1 - 1e-47 162.2 5.8 1.1e-47 162.1 4.0 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 Cytochrom_C_asm PF01578.15 CCF46190.1 - 0.00027 20.5 0.2 0.00037 20.0 0.1 1.2 1 0 0 1 1 1 1 Cytochrome C assembly protein OPT PF03169.10 CCF46194.1 - 8.5e-141 470.4 33.1 9.4e-141 470.2 22.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein EIAV_GP90 PF00971.13 CCF46194.1 - 0.5 8.7 4.3 0.76 8.1 0.1 2.2 2 0 0 2 2 2 0 EIAV coat protein, gp90 DUF2457 PF10446.4 CCF46195.1 - 0.018 13.7 5.7 0.035 12.8 3.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Conotoxin PF02950.12 CCF46195.1 - 0.23 12.2 2.4 5.8 7.7 0.0 2.7 2 0 0 2 2 2 0 Conotoxin Nop14 PF04147.7 CCF46195.1 - 0.26 9.1 3.5 0.36 8.7 2.4 1.1 1 0 0 1 1 1 0 Nop14-like family Nucleoplasmin PF03066.10 CCF46195.1 - 0.36 10.3 4.6 0.63 9.5 2.6 1.8 2 0 0 2 2 2 0 Nucleoplasmin TFIID-18kDa PF02269.11 CCF46197.1 - 5.1e-25 87.1 1.5 4.9e-24 83.9 0.4 2.3 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit CBFD_NFYB_HMF PF00808.18 CCF46197.1 - 0.059 13.4 1.4 24 5.1 0.2 3.6 4 0 0 4 4 4 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 CCF46197.1 - 0.31 11.3 4.5 2.6 8.3 0.2 3.1 3 0 0 3 3 3 0 Transcription initiation factor TFIID subunit A Peptidase_S10 PF00450.17 CCF46199.1 - 1.4e-51 175.9 0.0 2.3e-51 175.2 0.0 1.3 1 1 0 1 1 1 1 Serine carboxypeptidase Lactamase_B PF00753.22 CCF46200.1 - 3.9e-28 98.4 1.6 3.5e-27 95.3 1.1 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CCF46200.1 - 1.4e-06 27.9 0.0 1.9e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 CCF46200.1 - 0.0015 18.2 0.8 0.0043 16.7 0.2 1.8 1 1 1 2 2 2 1 Beta-lactamase superfamily domain Peripla_BP_4 PF13407.1 CCF46200.1 - 0.0074 15.6 1.0 0.047 13.0 0.2 2.0 2 0 0 2 2 2 1 Periplasmic binding protein domain LVIVD PF08309.6 CCF46200.1 - 0.044 12.7 0.3 0.083 11.8 0.2 1.4 1 0 0 1 1 1 0 LVIVD repeat BcrAD_BadFG PF01869.15 CCF46200.1 - 0.083 12.1 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Sarcoglycan_1 PF04790.8 CCF46200.1 - 0.11 11.6 0.1 0.14 11.2 0.1 1.2 1 0 0 1 1 1 0 Sarcoglycan complex subunit protein Chitin_bind_1 PF00187.14 CCF46201.1 - 1.1e-16 60.4 41.9 9.6e-09 35.0 14.1 2.9 2 1 1 3 3 3 2 Chitin recognition protein DEC-1_N PF04625.8 CCF46201.1 - 0.8 8.3 3.6 0.91 8.1 2.5 1.0 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region LEA_6 PF10714.4 CCF46201.1 - 6.5 6.6 8.0 6.7 6.5 4.9 1.5 1 1 0 1 1 1 0 Late embryogenesis abundant protein 18 Amidohydro_4 PF13147.1 CCF46202.1 - 1.4e-13 51.5 0.4 1.6e-13 51.3 0.3 1.2 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 CCF46202.1 - 8.6e-10 38.7 0.0 8.6e-10 38.7 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 CCF46202.1 - 1.6e-05 24.2 0.1 2.2e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Patatin PF01734.17 CCF46203.1 - 3.5e-18 66.2 0.2 4.2e-18 66.0 0.1 1.0 1 0 0 1 1 1 1 Patatin-like phospholipase MutS_III PF05192.13 CCF46204.1 - 1.1e-41 142.8 0.0 2.1e-41 141.9 0.0 1.5 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.12 CCF46204.1 - 1e-14 54.7 0.5 6e-14 52.2 0.0 2.5 2 1 0 2 2 2 1 MutS domain II MutS_IV PF05190.13 CCF46204.1 - 1.2e-14 54.2 1.0 3e-14 52.9 0.7 1.7 1 0 0 1 1 1 1 MutS family domain IV MutS_I PF01624.15 CCF46204.1 - 4.1e-12 46.1 0.0 8e-12 45.1 0.0 1.5 1 0 0 1 1 1 1 MutS domain I DUF3461 PF11944.3 CCF46204.1 - 0.074 12.9 1.1 0.24 11.2 0.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3461) DUF1777 PF08648.7 CCF46205.1 - 0.0024 17.6 11.4 0.0038 16.9 7.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) Epimerase PF01370.16 CCF46206.1 - 4.9e-57 193.0 0.0 6.3e-57 192.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 CCF46206.1 - 2.2e-24 85.8 0.0 3e-23 82.1 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 CCF46206.1 - 1.6e-21 76.4 0.1 1e-20 73.7 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 CCF46206.1 - 9.2e-21 73.7 0.0 1.2e-20 73.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 CCF46206.1 - 5.3e-20 71.4 0.0 7e-20 71.0 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.1 CCF46206.1 - 1e-08 35.4 0.0 1.7e-08 34.6 0.0 1.4 1 1 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 CCF46206.1 - 0.0023 17.8 0.0 0.14 12.0 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase RNA_pol_A_CTD PF03118.10 CCF46206.1 - 0.09 12.2 0.0 0.2 11.0 0.0 1.6 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain WD40 PF00400.27 CCF46207.1 - 9.7e-13 47.4 22.4 0.0032 17.2 0.1 7.4 8 1 0 8 8 8 5 WD domain, G-beta repeat p450 PF00067.17 CCF46208.1 - 1.7e-66 224.7 0.0 2.2e-66 224.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ParA PF10609.4 CCF46209.1 - 3e-33 113.5 0.0 4.6e-33 112.9 0.0 1.3 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 CCF46209.1 - 2.7e-14 53.0 0.0 3.7e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 CCF46209.1 - 1.4e-05 25.0 0.0 3.9e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.10 CCF46209.1 - 0.00016 20.8 0.1 0.0025 16.9 0.2 2.1 2 0 0 2 2 2 1 Anion-transporting ATPase MipZ PF09140.6 CCF46209.1 - 0.00092 18.3 0.0 0.002 17.2 0.0 1.5 1 1 0 1 1 1 1 ATPase MipZ AAA_25 PF13481.1 CCF46209.1 - 0.0023 17.3 0.1 0.0041 16.5 0.1 1.4 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 CCF46209.1 - 0.0088 15.2 0.0 0.015 14.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_30 PF13604.1 CCF46209.1 - 0.023 14.2 0.0 0.059 12.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 CCF46209.1 - 0.031 14.0 0.3 0.54 10.0 0.1 2.5 2 0 0 2 2 2 0 Part of AAA domain RNA_helicase PF00910.17 CCF46209.1 - 0.065 13.4 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 RNA helicase VirE PF05272.6 CCF46209.1 - 0.091 12.2 0.0 0.23 10.8 0.0 1.6 2 0 0 2 2 2 0 Virulence-associated protein E T2SE PF00437.15 CCF46209.1 - 0.13 11.1 0.1 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_5 PF07728.9 CCF46209.1 - 0.14 11.8 0.0 0.35 10.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Zn_Tnp_IS1595 PF12760.2 CCF46209.1 - 0.16 11.8 0.0 0.16 11.8 0.0 1.8 2 0 0 2 2 1 0 Transposase zinc-ribbon domain Ras PF00071.17 CCF46209.1 - 0.2 11.0 0.0 0.29 10.5 0.0 1.2 1 0 0 1 1 1 0 Ras family HEAT_2 PF13646.1 CCF46210.1 - 4.9e-28 97.2 6.4 2.2e-15 56.6 0.1 3.7 2 2 2 4 4 4 2 HEAT repeats HEAT_PBS PF03130.11 CCF46210.1 - 2.2e-17 61.6 5.6 0.0049 17.2 0.0 6.6 6 0 0 6 6 6 4 PBS lyase HEAT-like repeat HEAT_EZ PF13513.1 CCF46210.1 - 2.9e-10 40.3 7.7 0.00088 19.6 1.3 4.6 3 2 0 3 3 3 2 HEAT-like repeat HEAT PF02985.17 CCF46210.1 - 4.7e-07 29.3 4.4 0.68 10.1 0.0 5.6 6 0 0 6 6 6 3 HEAT repeat Arm PF00514.18 CCF46210.1 - 0.009 15.8 0.2 7.2 6.6 0.0 3.4 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat TFIIS_C PF01096.13 CCF46211.1 - 2.5e-15 55.8 1.6 2.5e-15 55.8 1.1 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 CCF46211.1 - 8e-05 22.2 7.6 0.00017 21.1 2.4 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit HypA PF01155.14 CCF46211.1 - 0.0079 15.8 2.8 1.1 8.9 0.4 2.3 2 0 0 2 2 2 2 Hydrogenase expression/synthesis hypA family C1_1 PF00130.17 CCF46211.1 - 0.026 14.2 1.0 0.026 14.2 0.7 1.9 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) OrfB_Zn_ribbon PF07282.6 CCF46211.1 - 0.027 14.1 8.9 0.87 9.2 0.9 2.5 2 1 0 2 2 2 0 Putative transposase DNA-binding domain Lar_restr_allev PF14354.1 CCF46211.1 - 0.028 14.7 11.4 0.13 12.6 0.4 3.2 2 1 1 3 3 3 0 Restriction alleviation protein Lar DZR PF12773.2 CCF46211.1 - 0.039 13.7 9.2 4.7 7.0 6.4 2.4 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.1 CCF46211.1 - 0.053 13.0 12.5 0.56 9.7 0.0 3.6 4 0 0 4 4 4 0 zinc-ribbon domain zf-ISL3 PF14690.1 CCF46211.1 - 0.088 12.8 4.4 5.3 7.1 0.0 3.1 3 0 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-RING_3 PF14369.1 CCF46211.1 - 0.15 12.1 7.0 0.78 9.7 0.4 2.7 3 0 0 3 3 3 0 zinc-finger zf-ribbon_3 PF13248.1 CCF46211.1 - 0.2 10.8 0.1 0.2 10.8 0.1 3.4 3 1 1 4 4 4 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 CCF46211.1 - 0.51 10.3 8.5 0.96 9.4 0.1 3.0 2 1 1 3 3 3 0 Zinc ribbon domain Mu-like_Com PF10122.4 CCF46211.1 - 0.87 8.6 3.7 2.2 7.3 0.5 2.2 2 0 0 2 2 2 0 Mu-like prophage protein Com IBR PF01485.16 CCF46211.1 - 0.9 9.4 8.8 2 8.3 0.6 2.7 2 1 0 2 2 2 0 IBR domain Ribosomal_S27e PF01667.12 CCF46211.1 - 1.2 8.6 6.1 15 5.2 0.5 2.9 2 1 0 2 2 2 0 Ribosomal protein S27 DUF3797 PF12677.2 CCF46211.1 - 1.6 8.4 10.7 4.5 6.9 2.4 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF3797) NOB1_Zn_bind PF08772.6 CCF46211.1 - 6.6 6.6 12.2 0.64 9.8 0.3 2.8 1 1 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like DUF164 PF02591.10 CCF46211.1 - 9.4 6.1 8.3 34 4.3 0.0 3.3 3 1 0 3 3 3 0 Putative zinc ribbon domain Nipped-B_C PF12830.2 CCF46212.1 - 8.1e-49 165.8 2.2 8.1e-49 165.8 1.5 2.6 2 1 0 2 2 2 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.2 CCF46212.1 - 6.1e-09 35.6 1.8 2.1e-08 33.9 0.5 2.5 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion Adaptin_N PF01602.15 CCF46212.1 - 6.1e-07 28.1 0.1 2.9e-05 22.6 0.0 3.0 3 0 0 3 3 3 1 Adaptin N terminal region HEAT PF02985.17 CCF46212.1 - 2.9e-06 26.8 0.6 0.68 10.1 0.0 4.9 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.2 CCF46212.1 - 1e-05 25.4 0.1 0.41 10.4 0.0 3.5 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.3 CCF46212.1 - 0.0094 15.3 0.4 1.9 7.8 0.0 3.3 3 0 0 3 3 3 1 CLASP N terminal MMS19_C PF12460.3 CCF46212.1 - 0.019 13.6 0.7 0.098 11.3 0.1 2.5 3 0 0 3 3 3 0 RNAPII transcription regulator C-terminal HEAT_2 PF13646.1 CCF46212.1 - 0.023 14.9 1.1 1.7 8.9 0.1 3.5 2 1 2 4 4 4 0 HEAT repeats FNIP_N PF14636.1 CCF46213.1 - 5.8e-30 104.4 0.0 5.8e-30 104.4 0.0 3.8 3 1 0 3 3 3 1 Folliculin-interacting protein N-terminus FNIP_M PF14637.1 CCF46213.1 - 0.014 15.0 0.2 0.17 11.4 0.0 2.2 1 1 0 2 2 2 0 Folliculin-interacting protein middle domain tRNA-synt_1 PF00133.17 CCF46214.1 - 2.2e-61 207.6 0.0 3.1e-61 207.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 CCF46214.1 - 1.6e-17 63.6 0.0 3e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 CCF46214.1 - 3.4e-06 25.9 0.0 0.038 12.6 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) zf-FPG_IleRS PF06827.9 CCF46214.1 - 7.4e-05 22.2 2.3 0.0002 20.9 1.6 1.8 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS EFG_C PF00679.19 CCF46215.1 - 2.6e-17 62.4 0.0 3.4e-17 62.0 0.0 1.1 1 0 0 1 1 1 1 Elongation factor G C-terminus DHFR_2 PF06442.6 CCF46215.1 - 0.084 12.5 0.0 0.4 10.3 0.0 1.9 2 0 0 2 2 2 0 R67 dihydrofolate reductase DDE_1 PF03184.14 CCF46216.1 - 3.1e-28 98.3 0.0 6.3e-28 97.3 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.11 CCF46216.1 - 2.5e-14 52.5 0.2 4.9e-14 51.5 0.2 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF46216.1 - 3.4e-12 45.9 0.2 1.3e-11 44.0 0.0 2.1 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.1 CCF46216.1 - 0.00013 21.4 0.0 0.00044 19.7 0.0 2.0 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 CCF46216.1 - 0.00057 19.8 0.1 0.0017 18.2 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_7 PF02796.10 CCF46216.1 - 0.0013 18.5 0.1 0.0026 17.5 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.1 CCF46216.1 - 0.0045 16.5 0.1 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_1 PF00126.22 CCF46216.1 - 0.076 12.7 0.9 0.16 11.7 0.6 1.5 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family SpoIIID PF12116.3 CCF46216.1 - 0.097 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Stage III sporulation protein D CENP-B_N PF04218.8 CCF46216.1 - 0.12 11.8 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_psq PF05225.11 CCF46217.1 - 1.3e-15 56.6 0.2 3.6e-15 55.2 0.2 1.7 2 0 0 2 2 2 1 helix-turn-helix, Psq domain HTH_23 PF13384.1 CCF46217.1 - 2e-05 24.0 0.1 3.5e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 CCF46217.1 - 0.0001 22.2 0.1 0.00015 21.6 0.0 1.4 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_7 PF02796.10 CCF46217.1 - 0.00014 21.6 0.1 0.00024 20.9 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.1 CCF46217.1 - 0.00059 19.3 0.1 0.0011 18.5 0.0 1.4 1 1 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_1 PF00126.22 CCF46217.1 - 0.0053 16.4 0.7 0.01 15.5 0.2 1.6 1 1 1 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family SpoIIID PF12116.3 CCF46217.1 - 0.01 15.7 0.0 0.021 14.7 0.0 1.5 1 1 0 1 1 1 0 Stage III sporulation protein D HTH_8 PF02954.14 CCF46217.1 - 0.014 14.9 0.9 0.12 11.9 0.1 2.2 1 1 1 2 2 2 0 Bacterial regulatory protein, Fis family CENP-B_N PF04218.8 CCF46217.1 - 0.018 14.4 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain DUF4164 PF13747.1 CCF46217.1 - 0.038 14.1 0.5 0.044 13.9 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) HTH_Tnp_1 PF01527.15 CCF46217.1 - 0.045 13.7 0.1 0.048 13.6 0.1 1.3 1 1 0 1 1 1 0 Transposase Med9 PF07544.8 CCF46217.1 - 0.091 12.5 0.1 0.12 12.1 0.1 1.3 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 HTH_psq PF05225.11 CCF46218.1 - 4.7e-11 42.0 0.2 1.3e-10 40.6 0.2 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF46218.1 - 9.7e-06 25.3 0.0 1.8e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 CCF46218.1 - 1.1e-05 24.7 0.0 1.6e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_AsnC-type PF13404.1 CCF46218.1 - 0.0033 16.9 0.1 0.011 15.2 0.1 1.9 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_23 PF13384.1 CCF46218.1 - 0.009 15.6 0.1 0.026 14.1 0.1 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_24 PF13412.1 CCF46218.1 - 0.088 12.2 0.1 0.21 11.0 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MFS_1 PF07690.11 CCF46220.1 - 5e-34 117.5 26.0 5e-34 117.5 18.1 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily SpoVAB PF13782.1 CCF46220.1 - 0.0034 17.3 2.1 0.0059 16.5 0.5 2.1 2 0 0 2 2 2 1 Stage V sporulation protein AB Dispanin PF04505.7 CCF46220.1 - 1.7 8.1 6.8 1.2 8.7 0.1 2.8 2 0 0 2 2 2 0 Interferon-induced transmembrane protein PepSY_TM PF03929.11 CCF46220.1 - 1.9 9.0 0.0 1.9 9.0 0.0 5.1 6 0 0 6 6 6 0 PepSY-associated TM helix ADH_zinc_N PF00107.21 CCF46221.1 - 4.1e-27 94.2 1.2 4.6e-27 94.1 0.5 1.3 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF46221.1 - 1.8e-18 67.6 0.0 2.5e-18 67.1 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Prp19 PF08606.6 CCF46222.1 - 1.4e-32 111.2 2.2 2.7e-32 110.3 1.5 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.27 CCF46222.1 - 1.6e-15 56.3 0.4 7.4e-07 28.8 0.0 5.2 6 0 0 6 6 6 3 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 CCF46222.1 - 1.9e-05 23.6 0.0 0.0066 15.2 0.0 2.1 1 1 1 2 2 2 2 Coatomer WD associated region zf-Nse PF11789.3 CCF46222.1 - 0.0015 17.9 0.0 0.0037 16.7 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.10 CCF46222.1 - 0.0023 17.8 0.0 0.0044 16.9 0.0 1.4 1 0 0 1 1 1 1 U-box domain Lactonase PF10282.4 CCF46222.1 - 0.027 13.5 0.0 0.092 11.8 0.0 1.9 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller VID27 PF08553.5 CCF46222.1 - 0.062 11.5 0.0 0.11 10.6 0.0 1.3 1 0 0 1 1 1 0 VID27 cytoplasmic protein OHCU_decarbox PF09349.5 CCF46223.1 - 7.6e-43 146.5 0.9 8.8e-43 146.3 0.6 1.0 1 0 0 1 1 1 1 OHCU decarboxylase tRNA-synt_His PF13393.1 CCF46223.1 - 0.026 13.5 0.4 0.035 13.1 0.3 1.3 1 1 0 1 1 1 0 Histidyl-tRNA synthetase Amino_oxidase PF01593.19 CCF46224.1 - 4.1e-58 197.5 1.9 6.4e-40 137.5 0.1 2.0 1 1 1 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 CCF46224.1 - 5.6e-17 61.5 1.0 4.3e-16 58.7 0.3 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF46224.1 - 7.4e-10 38.2 6.0 3.6e-09 35.9 4.2 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 CCF46224.1 - 2e-06 28.0 1.6 0.002 18.4 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF46224.1 - 4e-06 25.9 1.2 4e-06 25.9 0.8 1.8 3 0 0 3 3 3 1 FAD binding domain HI0933_like PF03486.9 CCF46224.1 - 4.2e-06 25.4 0.4 0.00015 20.3 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.9 CCF46224.1 - 5e-06 26.5 0.2 0.00042 20.2 0.2 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF46224.1 - 5.3e-06 25.6 0.2 1e-05 24.7 0.1 1.4 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.2 CCF46224.1 - 0.00018 20.6 0.6 0.00018 20.6 0.4 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 CCF46224.1 - 0.00028 20.0 0.8 0.00077 18.6 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.1 CCF46224.1 - 0.0011 19.0 0.3 0.019 15.0 0.4 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CCF46224.1 - 0.0074 15.1 0.3 0.011 14.6 0.2 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Lycopene_cycl PF05834.7 CCF46224.1 - 0.0094 14.9 1.7 0.025 13.5 0.5 1.9 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_9 PF13454.1 CCF46224.1 - 0.029 14.1 0.7 2.2 8.0 0.1 2.8 3 0 0 3 3 3 0 FAD-NAD(P)-binding Ank PF00023.25 CCF46226.1 - 0.0057 16.4 0.0 0.093 12.5 0.0 2.9 4 1 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.1 CCF46226.1 - 0.024 15.1 0.0 11 6.6 0.0 3.4 3 0 0 3 3 3 0 Ankyrin repeats (many copies) ACT_7 PF13840.1 CCF46227.1 - 4.6e-22 77.3 0.4 3.7e-19 68.0 0.1 2.5 2 0 0 2 2 2 2 ACT domain Fungal_trans PF04082.13 CCF46228.1 - 8.5e-16 57.6 0.1 1.3e-15 56.9 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Mito_fiss_reg PF05308.6 CCF46228.1 - 0.11 11.8 6.9 0.08 12.2 1.4 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator HET PF06985.6 CCF46230.1 - 3.3e-33 114.7 0.2 6.6e-33 113.8 0.0 1.6 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) HTH_32 PF13565.1 CCF46230.1 - 0.0097 16.6 2.5 0.019 15.7 0.9 2.1 2 0 0 2 2 2 1 Homeodomain-like domain Pro_isomerase PF00160.16 CCF46231.1 - 1.1e-23 84.1 0.0 1.4e-23 83.8 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD HTH_psq PF05225.11 CCF46234.1 - 1.5e-13 50.0 0.0 3.2e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF46234.1 - 2.8e-10 39.8 0.1 6.7e-10 38.6 0.0 1.7 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.1 CCF46234.1 - 0.0028 17.2 0.1 0.031 13.9 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 CCF46234.1 - 0.011 15.7 0.0 0.078 12.9 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_8 PF02954.14 CCF46234.1 - 0.13 11.8 0.1 0.5 9.9 0.0 2.0 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family DUF3129 PF11327.3 CCF46235.1 - 1.6e-45 155.1 6.9 1.9e-45 154.9 4.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3129) Tsg PF04668.7 CCF46236.1 - 0.03 14.5 0.0 0.033 14.3 0.0 1.2 1 0 0 1 1 1 0 Twisted gastrulation (Tsg) protein conserved region TetR_C_7 PF14246.1 CCF46236.1 - 0.064 13.4 0.3 15 5.8 0.0 2.4 2 0 0 2 2 2 0 AefR-like transcriptional repressor, C-terminal region EPSP_synthase PF00275.15 CCF46240.1 - 2.1e-128 428.3 0.0 6.2e-128 426.7 0.0 1.7 2 0 0 2 2 2 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.15 CCF46240.1 - 2.9e-100 334.5 0.0 4.6e-100 333.8 0.0 1.3 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.10 CCF46240.1 - 2e-62 210.7 0.0 3.3e-62 210.0 0.0 1.4 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.17 CCF46240.1 - 6.2e-37 126.8 0.0 1.8e-35 122.1 0.0 2.4 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.6 CCF46240.1 - 2.9e-22 78.4 0.0 6.1e-22 77.4 0.0 1.6 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Fe-ADH_2 PF13685.1 CCF46240.1 - 4.4e-09 35.9 0.0 1.4e-08 34.3 0.0 1.8 2 1 0 2 2 2 1 Iron-containing alcohol dehydrogenase Shikimate_DH PF01488.15 CCF46240.1 - 2.1e-05 24.6 0.0 6.7e-05 23.0 0.0 1.8 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_17 PF13207.1 CCF46240.1 - 2.5e-05 25.0 0.0 6.5e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 CCF46240.1 - 0.14 12.0 0.0 0.43 10.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 CCF46240.1 - 0.2 11.5 0.0 0.54 10.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 CCF46240.1 - 0.33 10.0 0.0 0.59 9.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin zf-C2H2 PF00096.21 CCF46241.1 - 4.6e-08 32.9 19.4 0.0095 16.2 0.9 4.4 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF46241.1 - 0.0012 19.0 23.2 0.0024 18.0 1.5 4.3 4 0 0 4 4 4 3 C2H2-type zinc finger p450 PF00067.17 CCF46242.1 - 2e-11 43.1 0.0 2.5e-11 42.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_cc PF11790.3 CCF46244.1 - 1.7e-34 119.2 0.0 1.9e-34 119.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core DUF2300 PF10062.4 CCF46244.1 - 0.089 12.5 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 Predicted secreted protein (DUF2300) JmjN PF02375.12 CCF46245.1 - 0.00089 18.7 0.4 0.0013 18.2 0.3 1.3 1 0 0 1 1 1 1 jmjN domain Actino_peptide PF14408.1 CCF46247.1 - 0.021 14.7 0.4 0.028 14.3 0.3 1.2 1 0 0 1 1 1 0 Ribosomally synthesized peptide in actinomycetes LAMTOR PF15454.1 CCF46247.1 - 0.62 10.3 4.9 0.76 10.1 3.4 1.2 1 0 0 1 1 1 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Pex14_N PF04695.8 CCF46247.1 - 0.64 10.0 4.6 0.64 10.0 3.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Dynamin_N PF00350.18 CCF46250.1 - 3.2e-17 62.8 5.5 4.4e-17 62.3 0.0 3.1 3 1 0 3 3 2 1 Dynamin family MMR_HSR1 PF01926.18 CCF46250.1 - 6.6e-06 26.0 0.1 0.00017 21.5 0.1 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 CCF46250.1 - 0.00032 19.9 0.1 0.0093 15.1 0.0 2.8 3 0 0 3 3 3 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 CCF46250.1 - 0.00072 19.5 3.0 0.0016 18.4 0.0 3.1 5 0 0 5 5 4 1 AAA ATPase domain ABC_tran PF00005.22 CCF46250.1 - 0.00083 19.6 0.0 0.00083 19.6 0.0 2.9 2 1 0 2 2 2 1 ABC transporter AAA_22 PF13401.1 CCF46250.1 - 0.01 15.9 0.0 0.31 11.2 0.0 3.1 1 1 1 2 2 2 0 AAA domain Miro PF08477.8 CCF46250.1 - 0.013 15.9 0.0 0.04 14.4 0.0 1.9 1 0 0 1 1 1 0 Miro-like protein Adeno_IVa2 PF02456.10 CCF46250.1 - 0.067 11.8 0.0 0.14 10.7 0.0 1.5 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_29 PF13555.1 CCF46250.1 - 0.076 12.5 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_17 PF13207.1 CCF46250.1 - 0.088 13.6 1.8 0.22 12.3 0.0 2.6 3 0 0 3 3 3 0 AAA domain AIG1 PF04548.11 CCF46250.1 - 0.13 11.3 0.0 0.13 11.3 0.0 2.7 4 0 0 4 4 4 0 AIG1 family HR1 PF02185.11 CCF46250.1 - 0.29 10.8 14.6 0.67 9.7 0.1 3.3 3 0 0 3 3 3 0 Hr1 repeat AAA_23 PF13476.1 CCF46250.1 - 0.52 10.6 0.0 0.52 10.6 0.0 3.7 3 1 0 3 3 2 0 AAA domain FlaC_arch PF05377.6 CCF46250.1 - 1.3 9.0 12.6 5 7.1 0.2 4.1 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) ADIP PF11559.3 CCF46250.1 - 4.5 7.1 16.6 38 4.1 0.1 2.9 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF1304 PF06993.7 CCF46251.1 - 9.4e-38 128.4 1.0 1.1e-37 128.2 0.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1304) Pribosyltran PF00156.22 CCF46253.1 - 4.8e-16 58.6 0.5 9.3e-16 57.6 0.3 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 CCF46253.1 - 0.084 12.0 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Thg1C PF14413.1 CCF46254.1 - 3.7e-11 42.7 0.1 4.2e-11 42.5 0.0 1.0 1 0 0 1 1 1 1 Thg1 C terminal domain Hex_IIIa PF02455.11 CCF46255.1 - 6 5.4 12.4 7.2 5.1 8.6 1.1 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) CAF-1_p150 PF11600.3 CCF46255.1 - 6.1 6.1 36.1 11 5.3 25.0 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Red1 PF07964.6 CCF46255.1 - 8.4 4.4 11.7 9.6 4.2 8.1 1.1 1 0 0 1 1 1 0 Rec10 / Red1 TP_methylase PF00590.15 CCF46256.1 - 0.00012 21.8 0.0 0.00019 21.1 0.0 1.5 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases TCL1_MTCP1 PF01840.12 CCF46256.1 - 0.076 12.5 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 TCL1/MTCP1 family F-box-like PF12937.2 CCF46257.1 - 0.0033 17.1 0.0 0.0061 16.2 0.0 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CCF46257.1 - 0.025 14.2 0.0 0.048 13.3 0.0 1.5 1 0 0 1 1 1 0 F-box domain Tyrosinase PF00264.15 CCF46259.1 - 2.5e-22 80.1 1.6 5.9e-18 65.8 0.0 2.3 2 0 0 2 2 2 2 Common central domain of tyrosinase Glyco_hydro_43 PF04616.9 CCF46260.1 - 3.8e-52 177.1 0.5 5.1e-52 176.7 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 DUF1349 PF07081.6 CCF46260.1 - 0.0012 18.2 0.0 0.002 17.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) FAD_binding_3 PF01494.14 CCF46261.1 - 1.6e-43 149.1 0.0 2.4e-43 148.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF46261.1 - 4.4e-08 32.4 0.1 0.00044 19.2 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF46261.1 - 3.9e-07 30.0 0.2 9e-07 28.8 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 CCF46261.1 - 0.00017 21.9 0.0 0.00043 20.6 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF46261.1 - 0.00021 19.9 0.0 0.00046 18.7 0.0 1.6 1 1 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.7 CCF46261.1 - 0.00032 19.7 0.0 0.0043 16.0 0.1 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_oxidored PF12831.2 CCF46261.1 - 0.00063 18.9 0.0 0.0014 17.8 0.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 CCF46261.1 - 0.00094 18.3 0.1 0.0014 17.7 0.1 1.2 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.19 CCF46261.1 - 0.0021 17.0 1.4 0.023 13.5 0.3 2.1 1 1 1 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.1 CCF46261.1 - 0.0029 17.6 0.1 0.012 15.6 0.1 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 CCF46261.1 - 0.035 13.1 0.0 1.2 8.0 0.0 2.7 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.1 CCF46261.1 - 0.11 12.2 0.1 0.5 10.1 0.0 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 CCF46261.1 - 0.15 11.9 0.1 0.25 11.2 0.0 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 CCF46261.1 - 0.2 11.3 0.0 0.57 9.8 0.0 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ATP-synt_ab PF00006.20 CCF46262.1 - 3.6e-113 376.3 0.0 5.1e-113 375.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 CCF46262.1 - 8.1e-19 68.1 0.8 2.2e-18 66.7 0.6 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 CCF46262.1 - 3e-15 56.1 3.4 1.3e-14 54.1 1.9 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain DUF4048 PF13257.1 CCF46263.1 - 3.1e-13 49.9 0.1 3.1e-13 49.9 0.1 4.3 3 1 2 5 5 5 3 Domain of unknown function (DUF4048) MitoNEET_N PF10660.4 CCF46264.1 - 0.057 13.2 0.9 0.11 12.3 0.5 1.6 1 1 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus Flavi_NS2A PF01005.14 CCF46264.1 - 0.071 12.3 0.1 0.091 12.0 0.0 1.2 1 0 0 1 1 1 0 Flavivirus non-structural protein NS2A GCIP PF13324.1 CCF46265.1 - 0.092 11.9 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Glyco_hydro_28 PF00295.12 CCF46266.1 - 4.8e-42 144.0 6.7 8e-42 143.3 4.6 1.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 28 PilX PF13681.1 CCF46266.1 - 0.55 10.7 3.8 2.9 8.4 0.1 3.1 3 1 1 4 4 4 0 Type IV pilus assembly protein PilX C-term Peptidase_S10 PF00450.17 CCF46267.1 - 1.1e-08 34.7 0.1 1.3e-08 34.4 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase DUF2910 PF11139.3 CCF46268.1 - 0.092 11.8 0.4 0.16 11.0 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2910) Methyltransf_23 PF13489.1 CCF46269.1 - 0.002 17.8 0.0 0.003 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.10 CCF46269.1 - 0.0044 16.1 0.0 0.0059 15.7 0.0 1.1 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_18 PF12847.2 CCF46269.1 - 0.012 16.2 0.0 0.022 15.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 CCF46269.1 - 0.032 13.6 0.0 0.053 12.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.14 CCF46269.1 - 0.037 13.5 0.0 0.051 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NST1 PF13945.1 CCF46270.1 - 1.3e-60 204.7 5.4 1.3e-60 204.7 3.8 4.6 2 2 1 4 4 4 1 Salt tolerance down-regulator Glyco_hydro_16 PF00722.16 CCF46271.1 - 9.1e-11 41.3 3.6 1.5e-10 40.6 2.5 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Glyco_hydro_16 PF00722.16 CCF46273.1 - 7.2e-33 113.4 2.3 8.9e-33 113.1 0.2 2.0 1 1 1 2 2 2 1 Glycosyl hydrolases family 16 Condensation PF00668.15 CCF46274.1 - 7.4e-48 162.9 0.0 9.6e-48 162.5 0.0 1.1 1 0 0 1 1 1 1 Condensation domain AMP-binding PF00501.23 CCF46274.1 - 7.8e-30 103.5 0.4 1.5e-29 102.6 0.3 1.4 1 0 0 1 1 1 1 AMP-binding enzyme HxxPF_rpt PF13745.1 CCF46274.1 - 2.3e-11 43.8 0.0 5.7e-11 42.5 0.0 1.7 1 0 0 1 1 1 1 HxxPF-repeated domain NIR_SIR_ferr PF03460.12 CCF46274.1 - 0.056 13.0 0.0 0.4 10.3 0.0 2.4 2 0 0 2 2 2 0 Nitrite/Sulfite reductase ferredoxin-like half domain DS PF01916.12 CCF46275.1 - 5e-135 449.3 0.0 6.2e-135 449.0 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Abhydrolase_6 PF12697.2 CCF46276.1 - 1.7e-07 31.3 1.1 2.8e-07 30.6 0.2 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF46276.1 - 0.0018 18.0 0.0 0.0036 17.0 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 CCF46276.1 - 0.015 15.5 0.1 0.032 14.4 0.0 1.5 2 0 0 2 2 2 0 Thioesterase domain Abhydrolase_1 PF00561.15 CCF46276.1 - 0.02 14.4 0.0 0.065 12.7 0.0 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold BTB PF00651.26 CCF46277.1 - 0.0008 19.3 0.0 0.0016 18.3 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain APH_6_hur PF04655.9 CCF46277.1 - 0.041 13.0 0.0 0.06 12.4 0.0 1.2 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Hce2 PF14856.1 CCF46278.1 - 2.6e-14 52.9 0.0 3.6e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor Abhydrolase_3 PF07859.8 CCF46279.1 - 1.4e-11 44.4 0.0 3.8e-11 42.9 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF46279.1 - 3.1e-05 23.7 0.0 5.4e-05 22.9 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF46279.1 - 0.00016 21.6 0.7 0.0003 20.7 0.1 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF46279.1 - 0.00037 19.7 0.0 0.061 12.5 0.0 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase family Esterase_phd PF10503.4 CCF46279.1 - 0.044 13.0 0.1 3.8 6.6 0.0 2.2 2 0 0 2 2 2 0 Esterase PHB depolymerase DUF4431 PF14485.1 CCF46279.1 - 0.15 11.6 0.0 0.54 9.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4431) Sulfate_transp PF00916.15 CCF46280.1 - 8.5e-53 179.1 3.7 8.5e-53 179.1 2.6 1.6 1 1 0 1 1 1 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 CCF46280.1 - 5.6e-30 102.8 3.7 1.9e-29 101.1 2.5 2.0 1 0 0 1 1 1 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 CCF46280.1 - 1.6e-15 56.5 0.0 3.5e-15 55.4 0.0 1.6 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.1 CCF46280.1 - 0.00031 20.7 0.0 0.0011 18.9 0.0 1.9 1 1 0 1 1 1 1 STAS domain Phage_G PF02306.10 CCF46281.1 - 0.011 15.4 0.1 0.018 14.6 0.0 1.4 1 0 0 1 1 1 0 Major spike protein (G protein) RRM_1 PF00076.17 CCF46281.1 - 0.086 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_S8 PF00082.17 CCF46282.1 - 9.7e-33 113.5 4.7 1.2e-32 113.2 3.2 1.1 1 0 0 1 1 1 1 Subtilase family cobW PF02492.14 CCF46284.1 - 4.4e-49 166.3 4.5 2.1e-35 121.7 0.2 2.2 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 CCF46284.1 - 1.8e-06 26.9 0.9 0.0003 19.6 0.0 2.2 2 0 0 2 2 2 2 ArgK protein CbiA PF01656.18 CCF46284.1 - 0.00052 19.4 0.3 0.0016 17.8 0.0 1.9 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.9 CCF46284.1 - 0.0022 17.6 0.0 0.0042 16.7 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B Viral_helicase1 PF01443.13 CCF46284.1 - 0.0048 16.4 0.0 0.011 15.2 0.0 1.6 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.1 CCF46284.1 - 0.0083 16.0 0.1 0.066 13.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CCF46284.1 - 0.0092 15.9 1.2 0.033 14.1 0.9 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CCF46284.1 - 0.013 15.5 0.1 0.071 13.2 0.0 2.1 2 1 0 2 2 2 0 AAA domain TFIIA PF03153.8 CCF46284.1 - 0.014 15.3 12.2 0.024 14.5 8.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AAA_11 PF13086.1 CCF46284.1 - 0.016 14.8 1.0 0.29 10.6 0.0 2.5 2 1 0 3 3 3 0 AAA domain Arch_ATPase PF01637.13 CCF46284.1 - 0.016 14.9 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 Archaeal ATPase UPF0079 PF02367.12 CCF46284.1 - 0.028 14.0 0.0 0.069 12.7 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_10 PF12846.2 CCF46284.1 - 0.031 13.7 0.0 0.057 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_29 PF13555.1 CCF46284.1 - 0.045 13.2 0.1 0.11 11.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF3396 PF11876.3 CCF46284.1 - 0.049 12.7 0.0 0.083 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3396) NACHT PF05729.7 CCF46284.1 - 0.076 12.6 0.1 0.26 10.9 0.1 1.9 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.1 CCF46284.1 - 0.11 12.3 0.0 0.29 11.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 CCF46284.1 - 0.13 12.0 0.0 0.46 10.2 0.0 1.8 2 0 0 2 2 2 0 Part of AAA domain AAA_18 PF13238.1 CCF46284.1 - 0.22 11.8 0.0 0.22 11.8 0.0 2.8 3 0 0 3 3 2 0 AAA domain Nop14 PF04147.7 CCF46284.1 - 0.59 7.9 20.6 0.77 7.6 14.3 1.1 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.7 CCF46284.1 - 0.72 9.5 13.4 1.3 8.6 9.3 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.9 CCF46284.1 - 1.3 6.9 13.4 1.9 6.4 9.3 1.2 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.6 CCF46284.1 - 1.3 7.0 10.4 2.3 6.2 7.2 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 KH_1 PF00013.24 CCF46286.1 - 5e-05 22.8 0.9 9.4e-05 21.9 0.6 1.4 1 0 0 1 1 1 1 KH domain Nuc_sug_transp PF04142.10 CCF46287.1 - 3.3e-11 42.7 3.6 5.5e-11 42.0 2.5 1.3 1 0 0 1 1 1 1 Nucleotide-sugar transporter 7TM-7TMR_HD PF07698.6 CCF46287.1 - 8.3 5.8 13.5 0.16 11.3 2.1 2.8 3 0 0 3 3 3 0 7TM receptor with intracellular HD hydrolase 2OG-FeII_Oxy_2 PF13532.1 CCF46288.1 - 3.7e-07 30.1 0.0 9.5e-07 28.8 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Steroid_dh PF02544.11 CCF46289.1 - 7.6e-15 54.9 1.1 1.6e-14 53.8 0.8 1.7 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.7 CCF46289.1 - 0.007 15.6 1.7 0.015 14.5 1.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.8 CCF46289.1 - 0.05 13.7 0.1 0.05 13.7 0.1 3.1 3 0 0 3 3 3 0 Phospholipid methyltransferase DUF2235 PF09994.4 CCF46290.1 - 8.8e-69 231.9 0.0 1.1e-68 231.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Abhydrolase_5 PF12695.2 CCF46290.1 - 0.06 13.0 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family Arm PF00514.18 CCF46291.1 - 4.2e-42 140.5 1.0 1.6e-13 49.8 0.0 4.4 5 0 0 5 5 5 3 Armadillo/beta-catenin-like repeat IBB PF01749.15 CCF46291.1 - 5.9e-24 84.0 1.1 8.7e-24 83.5 0.8 1.3 1 0 0 1 1 1 1 Importin beta binding domain HEAT_EZ PF13513.1 CCF46291.1 - 4.5e-13 49.2 1.4 4.1e-10 39.8 0.1 2.8 2 0 0 2 2 2 2 HEAT-like repeat HEAT_2 PF13646.1 CCF46291.1 - 8.9e-13 48.3 0.0 2.1e-10 40.7 0.0 3.0 1 1 2 3 3 3 3 HEAT repeats HEAT PF02985.17 CCF46291.1 - 5.2e-12 44.7 0.2 1.7e-06 27.5 0.0 3.7 3 0 0 3 3 3 2 HEAT repeat HEAT_PBS PF03130.11 CCF46291.1 - 0.0011 19.2 1.4 0.59 10.7 0.0 3.5 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat Arm_2 PF04826.8 CCF46291.1 - 0.0026 16.9 0.0 0.04 13.0 0.0 2.2 1 1 1 2 2 2 1 Armadillo-like SURF6 PF04935.7 CCF46291.1 - 0.67 9.1 6.8 0.99 8.6 4.7 1.1 1 0 0 1 1 1 0 Surfeit locus protein 6 DIL PF01843.14 CCF46292.1 - 1.9e-18 66.2 0.2 4.9e-18 64.9 0.1 1.7 1 0 0 1 1 1 1 DIL domain OAS1_C PF10421.4 CCF46292.1 - 0.045 13.2 0.3 0.19 11.2 0.0 2.1 3 0 0 3 3 3 0 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus WIYLD PF10440.4 CCF46292.1 - 0.22 11.5 1.1 0.69 9.8 0.0 2.3 2 1 0 2 2 2 0 Ubiquitin-binding WIYLD domain FAD_binding_3 PF01494.14 CCF46293.1 - 3e-11 42.9 0.0 3.5e-11 42.7 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 CCF46293.1 - 5.4e-09 35.9 0.4 5.5e-06 26.3 0.1 2.3 1 1 1 2 2 2 2 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF46293.1 - 5.9e-06 25.4 1.1 9.1e-06 24.8 0.8 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 CCF46293.1 - 1.5e-05 24.2 0.0 2.3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.9 CCF46293.1 - 6.3e-05 21.6 0.1 8.2e-05 21.2 0.0 1.1 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.1 CCF46293.1 - 7e-05 22.9 0.1 0.00015 21.8 0.1 1.4 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF46293.1 - 0.00017 20.6 0.2 0.0002 20.3 0.2 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 CCF46293.1 - 0.00021 21.2 0.1 0.00021 21.2 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF46293.1 - 0.00085 19.6 0.3 0.0012 19.1 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF46293.1 - 0.00095 17.8 0.0 0.00096 17.8 0.0 1.1 1 0 0 1 1 1 1 Tryptophan halogenase FAD_oxidored PF12831.2 CCF46293.1 - 0.001 18.2 0.0 0.001 18.2 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.17 CCF46293.1 - 0.0011 17.9 0.1 0.0012 17.8 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.16 CCF46293.1 - 0.0011 18.5 0.1 0.0019 17.8 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Amino_oxidase PF01593.19 CCF46293.1 - 0.0013 17.9 0.0 0.0016 17.6 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Shikimate_DH PF01488.15 CCF46293.1 - 0.0085 16.2 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.13 CCF46293.1 - 0.049 13.6 0.0 0.063 13.2 0.0 1.2 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_9 PF13454.1 CCF46293.1 - 0.06 13.1 0.1 0.087 12.5 0.1 1.3 1 0 0 1 1 1 0 FAD-NAD(P)-binding Med21 PF11221.3 CCF46294.1 - 0.11 12.4 0.0 0.32 10.9 0.0 1.8 1 0 0 1 1 1 0 Subunit 21 of Mediator complex Ufd2P_core PF10408.4 CCF46295.1 - 2.9e-47 161.2 0.1 3.4e-47 161.0 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.10 CCF46295.1 - 1.6e-25 88.8 0.8 2.9e-25 88.0 0.6 1.4 1 0 0 1 1 1 1 U-box domain Zds_C PF08632.5 CCF46295.1 - 0.091 12.1 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 Activator of mitotic machinery Cdc14 phosphatase activation C-term Macoilin PF09726.4 CCF46296.1 - 0.22 9.7 4.8 0.28 9.4 3.3 1.1 1 0 0 1 1 1 0 Transmembrane protein Innate_immun PF12782.2 CCF46296.1 - 2.2 7.4 14.4 0.13 11.5 0.8 2.2 2 0 0 2 2 2 0 Invertebrate innate immunity transcript family Hydrolase PF00702.21 CCF46298.1 - 1.2e-21 78.1 0.0 4.5e-21 76.2 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 CCF46298.1 - 1.6e-20 73.1 0.0 4e-20 71.8 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 CCF46298.1 - 8.6e-20 71.7 0.0 2e-19 70.5 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CCF46298.1 - 4.7e-05 23.2 0.0 0.00016 21.5 0.0 1.9 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 CCF46298.1 - 0.013 15.0 0.0 0.13 11.8 0.0 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF4059 PF13268.1 CCF46298.1 - 0.18 12.0 1.6 12 6.2 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4059) Ldh_1_N PF00056.18 CCF46299.1 - 1e-43 148.5 0.1 2.1e-43 147.5 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 CCF46299.1 - 2.5e-42 144.5 0.0 3.7e-42 144.0 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.14 CCF46299.1 - 0.0001 21.0 0.0 0.00015 20.5 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.11 CCF46299.1 - 0.093 12.0 0.0 0.3 10.3 0.0 1.8 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase zf-C2HC5 PF06221.8 CCF46300.1 - 4.2e-21 74.4 5.2 6.7e-21 73.7 3.6 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type FYVE PF01363.16 CCF46300.1 - 0.073 12.9 1.9 0.13 12.1 1.3 1.4 1 0 0 1 1 1 0 FYVE zinc finger FAM176 PF14851.1 CCF46300.1 - 0.61 9.7 3.4 1.8 8.2 2.3 1.8 1 0 0 1 1 1 0 FAM176 family CFEM PF05730.6 CCF46301.1 - 1.1e-11 44.3 7.4 2.2e-11 43.3 5.1 1.5 1 0 0 1 1 1 1 CFEM domain APO_RNA-bind PF05634.6 CCF46301.1 - 0.21 10.7 0.0 0.31 10.2 0.0 1.2 1 0 0 1 1 1 0 APO RNA-binding ATG13 PF10033.4 CCF46304.1 - 5.5e-71 238.6 0.0 7.6e-71 238.2 0.0 1.2 1 0 0 1 1 1 1 Autophagy-related protein 13 Oxidored_FMN PF00724.15 CCF46305.1 - 0.003 16.6 0.0 0.0032 16.5 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family RL11D PF11088.3 CCF46306.1 - 0.0067 16.2 0.8 0.082 12.7 0.0 2.0 1 1 0 2 2 2 1 Glycoprotein encoding membrane proteins RL5A and RL6 Astro_capsid_p PF12226.3 CCF46306.1 - 0.026 13.7 0.1 0.031 13.5 0.0 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Glyco_hydro_61 PF03443.9 CCF46308.1 - 3.1e-63 213.5 0.1 3.7e-63 213.2 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Glutaredoxin PF00462.19 CCF46309.1 - 1.3e-18 66.7 0.0 2e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_9 PF14595.1 CCF46309.1 - 0.00011 21.8 0.0 0.00012 21.6 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin DUF836 PF05768.9 CCF46309.1 - 0.00028 21.0 0.1 0.00034 20.8 0.1 1.3 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.1 CCF46309.1 - 0.0011 19.1 0.1 0.0018 18.4 0.1 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain GST_N_3 PF13417.1 CCF46309.1 - 0.0012 19.0 0.0 0.0018 18.4 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Thioredoxin PF00085.15 CCF46309.1 - 0.0016 18.0 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.15 CCF46309.1 - 0.0022 17.6 0.1 0.005 16.4 0.1 1.7 1 1 0 1 1 1 1 DSBA-like thioredoxin domain TraF PF13728.1 CCF46309.1 - 0.0071 15.8 0.0 0.0079 15.7 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Inos-1-P_synth PF01658.12 CCF46309.1 - 0.01 15.6 0.3 2.3 8.0 0.0 2.1 1 1 1 2 2 2 0 Myo-inositol-1-phosphate synthase Thioredoxin_4 PF13462.1 CCF46309.1 - 0.028 14.4 0.4 0.063 13.2 0.2 1.6 1 1 0 1 1 1 0 Thioredoxin Redoxin PF08534.5 CCF46309.1 - 0.047 13.2 0.0 0.052 13.0 0.0 1.2 1 0 0 1 1 1 0 Redoxin Thioredoxin_3 PF13192.1 CCF46309.1 - 0.078 12.7 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin domain Thioredoxin_8 PF13905.1 CCF46309.1 - 0.1 12.7 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like Glyco_transf_49 PF13896.1 CCF46309.1 - 0.12 11.4 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 Glycosyl-transferase for dystroglycan GST_N_2 PF13409.1 CCF46309.1 - 0.13 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Thioredoxin_7 PF13899.1 CCF46309.1 - 0.15 12.0 0.1 0.24 11.4 0.0 1.6 1 1 0 1 1 1 0 Thioredoxin-like Chalcone PF02431.10 CCF46310.1 - 3.7e-57 192.9 0.0 4.6e-57 192.6 0.0 1.1 1 0 0 1 1 1 1 Chalcone-flavanone isomerase CBFNT PF08143.6 CCF46311.1 - 0.073 14.1 3.2 0.11 13.6 2.2 1.3 1 0 0 1 1 1 0 CBFNT (NUC161) domain Sugar_tr PF00083.19 CCF46313.1 - 7.7e-105 351.0 21.4 8.8e-105 350.8 14.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF46313.1 - 2.2e-33 115.4 35.1 2.9e-30 105.1 12.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF791 PF05631.9 CCF46313.1 - 2.2e-05 23.3 1.9 2.2e-05 23.3 1.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF791) CoA_binding_3 PF13727.1 CCF46313.1 - 0.053 13.3 2.0 0.076 12.8 0.0 2.3 2 0 0 2 2 2 0 CoA-binding domain Aldedh PF00171.17 CCF46314.1 - 2.5e-179 596.4 1.5 2.8e-179 596.2 1.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 CCF46314.1 - 0.024 13.8 0.0 0.36 10.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Alpha-amylase PF00128.19 CCF46315.1 - 1.1e-29 103.8 1.6 3.2e-29 102.3 1.1 1.6 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_hydro_70 PF02324.11 CCF46315.1 - 1.4e-06 26.3 0.6 0.11 10.2 0.1 3.1 3 0 0 3 3 3 3 Glycosyl hydrolase family 70 Glyco_hydro_98M PF08306.6 CCF46315.1 - 0.017 13.8 1.1 0.034 12.8 0.8 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 98 DPCD PF14913.1 CCF46316.1 - 0.12 11.4 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 DPCD protein family DUF4381 PF14316.1 CCF46317.1 - 0.074 13.1 1.2 0.18 11.9 0.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) FixQ PF05545.6 CCF46317.1 - 0.83 9.3 10.7 11 5.7 0.1 4.0 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ Adeno_E4_34 PF04528.8 CCF46320.1 - 0.0094 15.5 0.0 0.012 15.2 0.0 1.0 1 0 0 1 1 1 1 Adenovirus early E4 34 kDa protein conserved region CPSase_L_D2 PF02786.12 CCF46321.1 - 1.9e-70 236.4 0.0 4.9e-59 199.1 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.14 CCF46321.1 - 2.3e-41 140.3 0.3 4.8e-41 139.3 0.0 1.7 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp_4 PF13535.1 CCF46321.1 - 2.6e-14 53.4 0.0 7.2e-07 29.1 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.1 CCF46321.1 - 5.4e-07 28.6 0.0 0.0038 16.0 0.0 2.2 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 CCF46321.1 - 3.2e-06 26.6 0.3 0.011 15.1 0.0 2.8 3 1 0 3 3 3 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 CCF46321.1 - 8.8e-06 25.1 0.0 0.054 12.8 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain CPSase_L_chain PF00289.17 CCF46321.1 - 1.1e-05 25.4 0.0 0.048 13.7 0.0 2.7 1 1 1 2 2 2 2 Carbamoyl-phosphate synthase L chain, N-terminal domain RimK PF08443.6 CCF46321.1 - 0.00068 19.1 0.0 0.0016 17.9 0.0 1.6 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GARS_A PF01071.14 CCF46321.1 - 0.095 12.2 0.0 0.59 9.6 0.0 2.2 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain BBE PF08031.7 CCF46322.1 - 1.6e-11 43.8 0.7 3.5e-11 42.8 0.5 1.6 1 0 0 1 1 1 1 Berberine and berberine like FAD_binding_4 PF01565.18 CCF46322.1 - 0.042 13.3 0.0 0.093 12.2 0.0 1.6 1 0 0 1 1 1 0 FAD binding domain CtaG_Cox11 PF04442.9 CCF46323.1 - 1.5e-56 190.4 0.0 2e-56 189.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 DUF3433 PF11915.3 CCF46325.1 - 1.2e-17 63.7 2.7 2.4e-10 40.4 0.1 3.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3433) Ribosomal_S5_C PF03719.10 CCF46327.1 - 3e-09 36.0 0.0 3.6e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain DASH_Dad3 PF08656.5 CCF46328.1 - 1.5e-29 101.4 0.3 1.9e-29 101.1 0.2 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad3 NmrA PF05368.8 CCF46329.1 - 3.4e-09 36.3 0.0 3.8e-09 36.1 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family ERG4_ERG24 PF01222.12 CCF46331.1 - 2.2e-140 468.0 7.8 2.5e-140 467.8 5.4 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 CCF46331.1 - 0.00011 21.5 0.1 0.00027 20.3 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) WSC PF01822.14 CCF46335.1 - 4.3e-14 52.1 10.0 8.5e-14 51.2 6.9 1.5 1 0 0 1 1 1 1 WSC domain TarH PF02203.10 CCF46335.1 - 0.12 12.1 0.1 0.34 10.7 0.0 1.7 2 0 0 2 2 2 0 Tar ligand binding domain homologue Herpes_US9 PF06072.6 CCF46335.1 - 4.9 7.0 6.0 41 4.1 4.2 2.3 1 1 0 1 1 1 0 Alphaherpesvirus tegument protein US9 HTH_psq PF05225.11 CCF46339.1 - 1.1e-09 37.7 0.1 1.4e-09 37.3 0.1 1.1 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_AsnC-type PF13404.1 CCF46339.1 - 0.047 13.2 0.3 0.07 12.6 0.2 1.4 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_23 PF13384.1 CCF46339.1 - 0.084 12.5 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 Homeodomain-like domain HTH_24 PF13412.1 CCF46339.1 - 0.087 12.2 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Fungal_trans_2 PF11951.3 CCF46340.1 - 0.003 16.2 0.0 0.0033 16.0 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain PTS_EIIB PF00367.15 CCF46340.1 - 0.065 12.4 0.1 0.92 8.7 0.0 2.1 2 0 0 2 2 2 0 phosphotransferase system, EIIB MFS_1 PF07690.11 CCF46343.1 - 2.1e-17 62.8 33.8 1.3e-15 56.9 21.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF46343.1 - 4.7e-07 28.7 11.1 4.7e-07 28.7 7.7 2.2 2 1 0 3 3 3 1 Sugar (and other) transporter UNC-93 PF05978.11 CCF46343.1 - 0.0006 19.3 5.1 0.0006 19.3 3.6 2.0 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 PUCC PF03209.10 CCF46343.1 - 0.00062 18.5 0.9 0.0014 17.4 0.6 1.7 1 1 0 1 1 1 1 PUCC protein DUF1275 PF06912.6 CCF46343.1 - 0.0073 15.5 0.7 0.0073 15.5 0.5 3.2 3 1 0 3 3 3 1 Protein of unknown function (DUF1275) ABC2_membrane PF01061.19 CCF46345.1 - 1.1e-05 24.6 2.8 6.7e-05 22.1 0.1 2.0 2 0 0 2 2 2 2 ABC-2 type transporter PDR_CDR PF06422.7 CCF46345.1 - 2.7e-05 23.7 0.7 5e-05 22.9 0.5 1.4 1 0 0 1 1 1 1 CDR ABC transporter Photo_RC PF00124.14 CCF46345.1 - 0.0061 15.6 0.0 0.0074 15.3 0.0 1.1 1 0 0 1 1 1 1 Photosynthetic reaction centre protein SIN1 PF05422.7 CCF46346.1 - 2.6e-34 118.6 0.1 4.8e-17 61.6 0.0 2.9 3 0 0 3 3 3 2 Stress-activated map kinase interacting protein 1 (SIN1) TUG-UBL1 PF11470.3 CCF46346.1 - 0.0058 16.5 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 GLUT4 regulating protein TUG PRCC PF10253.4 CCF46347.1 - 1.4e-38 133.4 3.0 1.4e-38 133.4 2.1 3.2 2 1 1 3 3 3 1 Mitotic checkpoint regulator, MAD2B-interacting HLH PF00010.21 CCF46348.1 - 0.037 13.7 0.0 0.14 11.8 0.0 2.0 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Vac_Fusion PF02346.11 CCF46349.1 - 0.049 13.0 0.6 0.077 12.4 0.4 1.3 1 0 0 1 1 1 0 Chordopoxvirus fusion protein Arginase PF00491.16 CCF46351.1 - 1.1e-05 24.8 0.0 1.2e-05 24.7 0.0 1.0 1 0 0 1 1 1 1 Arginase family RRM_1 PF00076.17 CCF46352.1 - 1.1e-14 53.8 0.0 1.4e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF46352.1 - 2.5e-12 46.5 0.0 3.3e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF46352.1 - 1.8e-10 40.5 0.0 2.7e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 CCF46352.1 - 0.017 14.9 0.1 0.03 14.1 0.0 1.5 1 1 0 1 1 1 0 RNA binding motif HET PF06985.6 CCF46353.1 - 5.9e-35 120.4 0.2 1e-34 119.6 0.1 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) FtsJ PF01728.14 CCF46354.1 - 0.027 14.4 0.0 0.039 13.9 0.0 1.4 1 1 0 1 1 1 0 FtsJ-like methyltransferase CRPA PF05745.6 CCF46356.1 - 0.22 11.2 0.6 0.71 9.6 0.0 1.9 2 0 0 2 2 2 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) MBOAT PF03062.14 CCF46357.1 - 1.9e-49 168.5 3.9 1.9e-49 168.5 2.7 1.5 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family Ter PF05472.6 CCF46358.1 - 0.069 12.2 0.0 0.076 12.1 0.0 1.0 1 0 0 1 1 1 0 DNA replication terminus site-binding protein (Ter protein) TPT PF03151.11 CCF46359.1 - 1.3e-11 44.3 8.2 1.3e-11 44.3 5.7 2.1 1 1 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 CCF46359.1 - 6.3e-11 41.7 13.0 7.2e-11 41.5 9.0 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 CCF46359.1 - 4.5e-05 23.5 17.8 6.1e-05 23.0 4.0 2.2 2 0 0 2 2 2 2 EamA-like transporter family PHO4 PF01384.15 CCF46359.1 - 0.003 16.2 11.3 0.0042 15.7 6.8 1.9 1 1 0 1 1 1 1 Phosphate transporter family Peptidase_A24 PF01478.13 CCF46359.1 - 5.8 7.1 15.2 2.7 8.1 3.8 3.4 2 1 0 2 2 2 0 Type IV leader peptidase family VirionAssem_T7 PF11653.3 CCF46360.1 - 0.083 13.6 0.7 0.18 12.5 0.4 1.7 1 1 0 1 1 1 0 Bacteriophage T7 virion assembly protein MFS_1 PF07690.11 CCF46362.1 - 1.6e-28 99.4 28.8 1.2e-27 96.5 20.5 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF46362.1 - 0.00032 19.3 14.0 0.00032 19.3 9.7 1.4 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 CCF46362.1 - 0.0026 16.0 4.4 0.0031 15.7 3.1 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3180 PF11377.3 CCF46362.1 - 0.0076 16.1 2.1 0.67 9.8 0.3 3.5 3 0 0 3 3 3 1 Protein of unknown function (DUF3180) DUF4231 PF14015.1 CCF46362.1 - 0.024 14.6 2.2 5.8 6.9 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) P12 PF12669.2 CCF46362.1 - 0.17 12.1 0.2 11 6.2 0.0 2.7 2 0 0 2 2 2 0 Virus attachment protein p12 family OATP PF03137.15 CCF46362.1 - 0.68 7.9 3.1 9.2 4.1 2.2 2.2 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Cu-oxidase_3 PF07732.10 CCF46363.1 - 1.3e-41 140.9 2.3 1.5e-40 137.5 0.2 2.5 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.17 CCF46363.1 - 1.2e-38 132.5 1.9 7.8e-35 120.1 0.0 3.4 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.9 CCF46363.1 - 4.9e-18 64.9 4.9 2.6e-12 46.4 0.1 3.8 3 1 0 3 3 3 2 Multicopper oxidase zf-RING_2 PF13639.1 CCF46364.1 - 4.6e-15 55.1 6.9 7.3e-15 54.5 4.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 CCF46364.1 - 2.2e-11 43.5 6.6 3.6e-11 42.9 4.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF46364.1 - 2.9e-10 39.6 3.5 4.9e-10 38.9 2.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF46364.1 - 7.1e-09 35.2 3.3 1.1e-08 34.5 2.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF46364.1 - 1.6e-08 34.1 4.1 2.7e-08 33.3 2.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 CCF46364.1 - 3.6e-07 29.9 5.0 8e-07 28.8 3.5 1.6 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 CCF46364.1 - 1.5e-05 24.6 3.2 2.9e-05 23.6 2.2 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.2 CCF46364.1 - 3.8e-05 23.6 6.0 3.8e-05 23.6 4.2 2.0 2 1 0 2 2 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 CCF46364.1 - 5e-05 23.0 0.8 7.3e-05 22.5 0.5 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger TerY-C PF15616.1 CCF46364.1 - 0.00079 19.3 2.5 0.0011 18.8 1.7 1.2 1 0 0 1 1 1 1 TerY-C metal binding domain RskA PF10099.4 CCF46364.1 - 0.0019 17.9 0.2 0.0029 17.3 0.1 1.3 1 0 0 1 1 1 1 Anti-sigma-K factor rskA zf-RING_4 PF14570.1 CCF46364.1 - 0.0043 16.6 5.0 0.011 15.3 3.5 1.6 1 1 1 2 2 2 1 RING/Ubox like zinc-binding domain Vps39_2 PF10367.4 CCF46364.1 - 0.011 15.8 0.1 0.019 15.1 0.1 1.4 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 Prok-RING_4 PF14447.1 CCF46364.1 - 0.012 15.1 8.4 0.17 11.4 6.2 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-ribbon_3 PF13248.1 CCF46364.1 - 0.12 11.5 11.4 0.88 8.8 0.4 3.4 3 0 0 3 3 3 0 zinc-ribbon domain C1_3 PF07649.7 CCF46364.1 - 0.17 11.9 0.7 0.17 11.9 0.5 2.0 3 0 0 3 3 1 0 C1-like domain FdhE PF04216.7 CCF46364.1 - 0.19 11.4 1.8 0.2 11.3 1.3 1.3 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation FYVE PF01363.16 CCF46364.1 - 0.25 11.2 6.6 1.1 9.2 4.6 2.2 1 1 0 1 1 1 0 FYVE zinc finger zf-RING_6 PF14835.1 CCF46364.1 - 0.34 10.7 7.1 1.9 8.3 5.0 1.9 1 1 1 2 2 2 0 zf-RING of BARD1-type protein DZR PF12773.2 CCF46364.1 - 0.45 10.3 7.3 5.3 6.9 5.1 2.3 1 1 0 1 1 1 0 Double zinc ribbon IBR PF01485.16 CCF46364.1 - 1.8 8.5 6.0 32 4.4 4.1 2.5 2 1 1 3 3 3 0 IBR domain Glyco_hydro_7 PF00840.15 CCF46365.1 - 2e-19 69.2 0.0 2.3e-19 69.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 RRM_1 PF00076.17 CCF46366.1 - 1.3e-14 53.5 0.0 2.1e-12 46.4 0.0 2.3 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF46366.1 - 2e-09 37.3 0.0 3.1e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF46366.1 - 0.0057 16.4 0.0 0.0091 15.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NACHT PF05729.7 CCF46368.1 - 1.1e-06 28.3 0.0 4e-06 26.6 0.0 2.1 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.1 CCF46368.1 - 9.1e-05 22.6 0.0 0.00046 20.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CCF46368.1 - 0.00011 22.2 0.8 0.0052 16.7 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain AAA_23 PF13476.1 CCF46368.1 - 0.00037 20.8 1.1 0.0024 18.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 CCF46368.1 - 0.00046 19.7 2.3 0.0035 16.8 0.0 3.0 3 0 0 3 3 3 1 AAA-like domain AAA_17 PF13207.1 CCF46368.1 - 0.001 19.8 1.6 0.027 15.3 0.0 4.0 3 1 0 4 4 4 1 AAA domain MMR_HSR1 PF01926.18 CCF46368.1 - 0.0044 16.9 0.0 0.013 15.4 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.22 CCF46368.1 - 0.0047 17.2 0.0 0.014 15.6 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_18 PF13238.1 CCF46368.1 - 0.0071 16.6 0.0 0.037 14.3 0.0 2.4 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 CCF46368.1 - 0.011 15.7 0.4 4.7 7.1 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 CCF46368.1 - 0.012 14.9 0.3 0.056 12.8 0.0 2.3 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.1 CCF46368.1 - 0.013 14.9 0.1 0.03 13.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SF PF00482.18 CCF46368.1 - 0.016 15.0 3.8 0.1 12.5 1.7 2.8 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F NTPase_1 PF03266.10 CCF46368.1 - 0.042 13.5 0.3 0.31 10.7 0.0 2.2 2 0 0 2 2 2 0 NTPase Synaptonemal_3 PF15191.1 CCF46368.1 - 0.082 12.6 0.5 0.41 10.4 0.1 2.4 2 0 0 2 2 2 0 Synaptonemal complex central element protein 3 AAA_33 PF13671.1 CCF46368.1 - 0.098 12.5 0.6 0.29 10.9 0.1 2.1 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.17 CCF46368.1 - 0.11 12.6 0.1 0.3 11.2 0.1 1.7 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.1 CCF46368.1 - 0.17 11.6 0.0 0.58 9.9 0.0 1.9 1 0 0 1 1 1 0 Part of AAA domain Myticin-prepro PF10690.4 CCF46369.1 - 0.72 9.9 4.9 0.81 9.7 3.4 1.1 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel p450 PF00067.17 CCF46370.1 - 1.5e-12 46.7 0.0 1.9e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_2 PF00891.13 CCF46372.1 - 5.2e-12 45.4 0.0 2.7e-10 39.8 0.0 2.3 1 1 1 2 2 2 2 O-methyltransferase Dimerisation PF08100.6 CCF46372.1 - 0.05 13.4 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Dimerisation domain Adap_comp_sub PF00928.16 CCF46373.1 - 3.1e-59 200.2 0.0 1.8e-58 197.6 0.0 1.9 1 1 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 CCF46373.1 - 0.00027 20.6 0.0 0.00041 20.0 0.0 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain AA_permease_2 PF13520.1 CCF46375.1 - 7e-10 38.0 3.5 7e-10 38.0 2.5 1.6 1 1 0 1 1 1 1 Amino acid permease Glyco_hydro_61 PF03443.9 CCF46377.1 - 2.1e-44 151.9 0.1 2.1e-44 151.9 0.1 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 Transcript_VP30 PF11507.3 CCF46377.1 - 0.08 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Ebola virus-specific transcription factor VP30 PAP2 PF01569.16 CCF46378.1 - 1.5e-20 73.1 2.0 1.5e-20 73.1 1.4 2.0 2 0 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.1 CCF46378.1 - 1.5 9.1 7.2 0.52 10.6 1.7 2.5 2 1 0 2 2 2 0 PAP2 superfamily C-terminal BTP PF05232.7 CCF46378.1 - 4.8 7.0 7.3 20 4.9 0.2 2.8 2 0 0 2 2 2 0 Bacterial Transmembrane Pair family Myb_DNA-bind_4 PF13837.1 CCF46379.1 - 0.011 15.9 0.9 0.018 15.1 0.1 1.7 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain BCDHK_Adom3 PF10436.4 CCF46382.1 - 2.2e-42 144.3 0.0 3e-42 143.9 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 CCF46382.1 - 0.006 16.2 0.0 0.016 14.9 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Inhibitor_I9 PF05922.11 CCF46383.1 - 1.7e-12 47.6 0.2 1.8e-12 47.6 0.2 1.0 1 0 0 1 1 1 1 Peptidase inhibitor I9 DUF1152 PF06626.7 CCF46384.1 - 0.032 13.3 0.5 0.037 13.1 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1152) Glyco_hydro_46 PF01374.13 CCF46384.1 - 0.066 12.7 0.9 0.087 12.3 0.6 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 46 HET PF06985.6 CCF46386.1 - 3.7e-22 78.9 0.0 6.3e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) HsbA PF12296.3 CCF46387.1 - 0.00011 21.9 1.8 0.00018 21.3 1.2 1.3 1 0 0 1 1 1 1 Hydrophobic surface binding protein A DUF2360 PF10152.4 CCF46387.1 - 3.1 8.0 17.0 16 5.7 11.8 2.0 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) PAT1 PF09770.4 CCF46387.1 - 9 4.3 22.7 10 4.2 15.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4129 PF13559.1 CCF46388.1 - 0.00053 19.8 0.5 0.0012 18.7 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4129) Inhibitor_Mig-6 PF11555.3 CCF46390.1 - 2.2 8.7 5.6 13 6.2 0.8 2.3 1 1 1 2 2 2 0 EGFR receptor inhibitor Mig-6 PNRC PF15365.1 CCF46391.1 - 0.087 12.8 1.6 0.27 11.2 0.3 2.0 2 0 0 2 2 2 0 Proline-rich nuclear receptor coactivator Glyco_transf_8 PF01501.15 CCF46392.1 - 2.7e-14 53.1 0.0 3e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 MFS_1 PF07690.11 CCF46393.1 - 4.6e-17 61.7 35.9 5.7e-17 61.4 24.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1290 PF06947.7 CCF46393.1 - 0.63 9.9 3.7 5.4 6.9 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1290) Maf PF02545.9 CCF46394.1 - 4.7e-45 153.1 0.0 6.2e-45 152.7 0.0 1.1 1 0 0 1 1 1 1 Maf-like protein Glyco_hydro_47 PF01532.15 CCF46395.1 - 8e-161 535.6 0.0 9.2e-161 535.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Rhv PF00073.15 CCF46395.1 - 0.099 12.3 0.2 0.19 11.3 0.1 1.4 1 0 0 1 1 1 0 picornavirus capsid protein Utp11 PF03998.8 CCF46396.1 - 2.5e-58 197.7 17.7 2.9e-58 197.5 12.3 1.0 1 0 0 1 1 1 1 Utp11 protein FlxA PF14282.1 CCF46396.1 - 1.8 8.5 8.9 4.2 7.3 3.0 3.1 3 0 0 3 3 3 0 FlxA-like protein UPRTase PF14681.1 CCF46398.1 - 7e-42 142.9 0.1 9.1e-42 142.6 0.1 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 CCF46398.1 - 5.5e-06 26.1 1.6 0.00061 19.5 1.3 2.3 2 0 0 2 2 2 2 Phosphoribosyl transferase domain PRTase_2 PF15609.1 CCF46398.1 - 0.00066 19.0 0.0 0.00086 18.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase G-alpha PF00503.15 CCF46399.1 - 5e-60 203.2 0.4 6.6e-60 202.8 0.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 CCF46399.1 - 0.0028 16.9 0.2 0.0053 16.0 0.1 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_29 PF13555.1 CCF46399.1 - 0.0049 16.3 0.1 0.012 15.0 0.1 1.6 1 1 0 1 1 1 1 P-loop containing region of AAA domain MCM PF00493.18 CCF46399.1 - 0.039 12.7 0.1 0.064 12.0 0.0 1.3 1 1 0 1 1 1 0 MCM2/3/5 family FtsK_SpoIIIE PF01580.13 CCF46399.1 - 0.057 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF3413 PF11893.3 CCF46400.1 - 0.013 14.3 1.0 0.018 13.9 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) Fe-S_biosyn PF01521.15 CCF46401.1 - 4e-12 46.0 0.0 2.3e-10 40.4 0.0 2.2 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis Endonuc_BglI PF14562.1 CCF46402.1 - 0.027 13.3 0.0 0.032 13.0 0.0 1.1 1 0 0 1 1 1 0 Restriction endonuclease BglI SDH_alpha PF03313.10 CCF46403.1 - 3.7e-65 219.7 0.2 6.1e-65 219.0 0.2 1.3 1 1 0 1 1 1 1 Serine dehydratase alpha chain SDH_beta PF03315.10 CCF46403.1 - 2.1e-06 27.8 0.1 4.8e-06 26.7 0.1 1.6 1 0 0 1 1 1 1 Serine dehydratase beta chain Ricin_B_lectin PF00652.17 CCF46404.1 - 2.8e-09 37.0 0.0 9e-06 25.7 0.0 2.3 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain AAA PF00004.24 CCF46405.1 - 2.5e-42 144.2 0.0 4.5e-42 143.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 CCF46405.1 - 1.8e-24 85.3 0.2 1.3e-23 82.6 0.2 2.5 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.13 CCF46405.1 - 4.9e-23 80.7 2.4 1.4e-22 79.2 1.4 2.0 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain RuvB_N PF05496.7 CCF46405.1 - 8.5e-07 28.2 0.0 1.4e-06 27.5 0.0 1.4 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 CCF46405.1 - 3.9e-06 27.6 0.0 1.8e-05 25.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 CCF46405.1 - 9.8e-06 25.1 0.0 1.9e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.8 CCF46405.1 - 1.2e-05 24.2 0.0 2.7e-05 23.0 0.0 1.5 2 0 0 2 2 2 1 TIP49 C-terminus AAA_22 PF13401.1 CCF46405.1 - 2e-05 24.7 0.0 0.0017 18.5 0.0 2.6 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 CCF46405.1 - 3.3e-05 24.0 0.1 0.01 16.0 0.0 3.0 3 0 0 3 3 3 1 RNA helicase AAA_5 PF07728.9 CCF46405.1 - 3.4e-05 23.5 0.0 0.00023 20.8 0.0 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 CCF46405.1 - 4.9e-05 23.3 0.2 0.0046 16.9 0.0 3.0 2 1 1 3 3 3 1 AAA ATPase domain AAA_14 PF13173.1 CCF46405.1 - 5e-05 23.2 0.0 0.00012 21.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 CCF46405.1 - 0.00038 19.4 0.0 0.0042 16.0 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_33 PF13671.1 CCF46405.1 - 0.00066 19.5 0.0 0.0016 18.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 CCF46405.1 - 0.0021 17.5 0.1 0.26 10.6 0.1 2.4 1 1 0 2 2 2 1 AAA domain AAA_2 PF07724.9 CCF46405.1 - 0.0058 16.5 0.0 0.029 14.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.1 CCF46405.1 - 0.0096 16.2 0.1 0.025 14.8 0.0 1.8 2 0 0 2 2 1 1 AAA domain NACHT PF05729.7 CCF46405.1 - 0.0097 15.5 0.0 0.56 9.8 0.0 2.4 1 1 1 2 2 2 1 NACHT domain AAA_24 PF13479.1 CCF46405.1 - 0.015 14.8 0.0 0.028 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 CCF46405.1 - 0.02 14.0 0.1 0.12 11.4 0.0 2.3 1 1 0 1 1 1 0 Zeta toxin Mg_chelatase PF01078.16 CCF46405.1 - 0.021 14.0 0.0 0.062 12.4 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 CCF46405.1 - 0.024 14.3 0.0 0.067 12.9 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA_21 PF13304.1 CCF46405.1 - 0.027 14.4 0.1 2.8 7.8 0.0 2.3 1 1 1 2 2 2 0 AAA domain PhoH PF02562.11 CCF46405.1 - 0.039 13.1 0.1 0.084 12.0 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Bac_DnaA PF00308.13 CCF46405.1 - 0.043 13.4 0.0 0.13 11.8 0.0 1.7 1 1 0 1 1 1 0 Bacterial dnaA protein USP8_dimer PF08969.6 CCF46405.1 - 0.05 13.5 1.4 0.11 12.4 0.9 1.5 1 0 0 1 1 1 0 USP8 dimerisation domain Sigma54_activ_2 PF14532.1 CCF46405.1 - 0.052 13.5 0.0 0.14 12.1 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain Torsin PF06309.6 CCF46405.1 - 0.074 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Torsin KaiC PF06745.8 CCF46405.1 - 0.083 11.9 0.0 4.7 6.2 0.0 2.5 2 1 1 3 3 3 0 KaiC ResIII PF04851.10 CCF46405.1 - 0.087 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Parvo_NS1 PF01057.12 CCF46405.1 - 0.09 11.6 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.21 CCF46405.1 - 0.12 11.8 0.0 0.41 10.0 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.1 CCF46405.1 - 0.13 12.1 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Prefoldin_2 PF01920.15 CCF46406.1 - 8.4e-19 67.3 14.1 1.1e-18 66.9 9.7 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.1 CCF46406.1 - 0.013 15.2 4.8 0.018 14.7 3.3 1.3 1 0 0 1 1 1 0 Prefoldin subunit DUF1732 PF08340.6 CCF46406.1 - 0.044 13.5 3.7 0.46 10.3 0.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1732) Scaffolding_pro PF11418.3 CCF46406.1 - 0.054 13.8 4.7 0.1 12.9 1.2 2.1 1 1 1 2 2 2 0 Phi29 scaffolding protein IncA PF04156.9 CCF46406.1 - 0.08 12.5 12.3 0.23 11.0 8.5 1.6 1 1 0 1 1 1 0 IncA protein Prefoldin PF02996.12 CCF46406.1 - 0.15 11.6 10.7 0.81 9.3 0.2 2.8 2 1 1 3 3 3 0 Prefoldin subunit YtxC PF08812.6 CCF46406.1 - 0.2 11.1 1.7 0.24 10.8 1.2 1.1 1 0 0 1 1 1 0 YtxC-like family CENP-F_leu_zip PF10473.4 CCF46406.1 - 0.66 9.8 10.9 1.8 8.3 3.4 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CDC37_N PF03234.9 CCF46406.1 - 0.76 10.0 6.8 0.91 9.8 4.7 1.1 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding ERp29 PF07749.7 CCF46406.1 - 0.87 10.2 5.6 2.5 8.7 3.9 1.8 1 1 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain Spc24 PF08286.6 CCF46406.1 - 1.4 8.5 10.6 0.32 10.7 4.4 1.9 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Herpes_BLRF2 PF05812.7 CCF46406.1 - 2 8.2 6.9 3.2 7.5 4.6 1.8 1 1 0 1 1 1 0 Herpesvirus BLRF2 protein NPV_P10 PF05531.7 CCF46406.1 - 2.2 8.5 5.2 2.5 8.3 2.2 2.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Atg14 PF10186.4 CCF46406.1 - 2.2 7.1 13.3 8.9 5.1 9.2 1.8 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4201 PF13870.1 CCF46406.1 - 2.3 7.6 11.1 7.3 5.9 0.2 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) Occludin_ELL PF07303.8 CCF46406.1 - 2.3 8.9 6.3 2.6 8.8 3.8 1.7 1 1 1 2 2 2 0 Occludin homology domain Spc7 PF08317.6 CCF46406.1 - 2.6 6.6 10.5 3.1 6.3 7.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Rho_Binding PF08912.6 CCF46406.1 - 2.6 8.3 10.3 1.4 9.2 4.4 2.1 2 0 0 2 2 2 0 Rho Binding GAS PF13851.1 CCF46406.1 - 3 6.9 12.4 0.68 9.1 6.2 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF904 PF06005.7 CCF46406.1 - 4.7 7.5 13.4 8 6.8 9.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF904) DUF972 PF06156.8 CCF46406.1 - 7.5 6.9 8.4 13 6.1 5.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF972) JAB PF01398.16 CCF46408.1 - 1.2e-14 54.0 0.0 2.6e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 CCF46408.1 - 2.5e-06 27.0 0.0 8.3e-06 25.3 0.0 1.9 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain USP8_dimer PF08969.6 CCF46408.1 - 5.3e-05 23.1 0.0 0.00012 22.0 0.0 1.6 1 0 0 1 1 1 1 USP8 dimerisation domain DUF1294 PF06961.8 CCF46409.1 - 0.19 11.7 1.0 1.5 8.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1294) dCMP_cyt_deam_1 PF00383.17 CCF46410.1 - 6.6e-10 38.5 0.0 1.2e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.1 CCF46410.1 - 1.4 8.7 7.8 0.53 10.1 1.2 2.6 2 1 0 2 2 2 0 Bd3614-like deaminase Bd3614_N PF14442.1 CCF46410.1 - 2.5 8.0 6.4 4.7 7.1 4.5 1.4 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal PAS_4 PF08448.5 CCF46412.1 - 0.00091 19.2 0.7 0.12 12.4 0.0 2.6 3 0 0 3 3 3 2 PAS fold HisKA PF00512.20 CCF46414.1 - 1.5e-11 44.1 0.1 3.3e-11 43.0 0.1 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain DUF2788 PF10981.3 CCF46414.1 - 0.17 11.7 0.0 0.32 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2788) Pec_lyase_C PF00544.14 CCF46415.1 - 1.8e-18 66.7 0.3 2.6e-18 66.2 0.2 1.3 1 0 0 1 1 1 1 Pectate lyase Zn_clus PF00172.13 CCF46417.1 - 8.6e-09 35.1 11.9 1.2e-08 34.7 8.2 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.7 CCF46417.1 - 0.43 10.7 13.8 0.54 10.4 2.3 2.2 1 1 1 2 2 2 0 Dickkopf N-terminal cysteine-rich region Fn3-like PF14310.1 CCF46419.1 - 4e-22 77.9 0.1 5.7e-22 77.4 0.1 1.2 1 0 0 1 1 1 1 Fibronectin type III-like domain D-ser_dehydrat PF14031.1 CCF46420.1 - 1.5e-21 76.3 0.0 3.1e-21 75.3 0.0 1.6 1 0 0 1 1 1 1 Putative serine dehydratase domain Ala_racemase_N PF01168.15 CCF46420.1 - 1.8e-14 53.8 1.2 2.7e-14 53.2 0.6 1.5 1 1 0 1 1 1 1 Alanine racemase, N-terminal domain tRNA_SAD PF07973.9 CCF46421.1 - 8.7e-09 35.1 1.3 1.8e-08 34.1 0.9 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain PH_8 PF15409.1 CCF46421.1 - 0.029 14.4 0.1 0.065 13.3 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain Aa_trans PF01490.13 CCF46422.1 - 1.8e-43 148.6 34.0 2e-43 148.4 23.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 CCF46422.1 - 0.00012 21.0 15.6 0.00012 21.0 10.8 1.7 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family CAAD PF14159.1 CCF46422.1 - 1.5 8.5 10.4 0.046 13.3 1.5 2.9 2 1 0 2 2 2 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase p450 PF00067.17 CCF46423.1 - 2.4e-54 184.6 0.0 3e-54 184.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_S10 PF00450.17 CCF46424.1 - 1.8e-72 244.8 0.0 2.4e-72 244.3 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Methyltransf_23 PF13489.1 CCF46425.1 - 5.8e-25 87.8 0.0 8.3e-25 87.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF46425.1 - 2.6e-10 40.1 0.0 1.1e-09 38.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF46425.1 - 7.2e-10 39.4 0.0 6.2e-09 36.4 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF46425.1 - 1.7e-08 34.8 0.0 3.8e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF46425.1 - 2.3e-06 28.0 0.0 1.6e-05 25.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF46425.1 - 0.00014 22.1 0.0 0.00027 21.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF46425.1 - 0.00059 18.9 0.0 0.0012 17.9 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 CCF46425.1 - 0.00075 18.9 0.0 0.002 17.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain Ubie_methyltran PF01209.13 CCF46425.1 - 0.001 18.2 0.0 0.019 14.0 0.0 2.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.14 CCF46425.1 - 0.002 18.1 0.0 0.0029 17.6 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase PrmA PF06325.8 CCF46425.1 - 0.0032 16.6 0.0 0.0063 15.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 CCF46425.1 - 0.016 15.2 0.0 0.076 13.0 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain UDPG_MGDP_dh_N PF03721.9 CCF46427.1 - 3e-20 72.3 0.0 1.5e-18 66.8 0.0 2.4 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.14 CCF46427.1 - 9.7e-19 67.3 0.0 2e-18 66.4 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.10 CCF46427.1 - 0.0015 18.6 0.0 0.0034 17.5 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain TrkA_N PF02254.13 CCF46427.1 - 0.0073 16.3 0.0 0.026 14.5 0.0 1.9 2 0 0 2 2 2 1 TrkA-N domain F420_oxidored PF03807.12 CCF46427.1 - 0.02 15.3 0.0 0.43 11.0 0.0 2.7 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Chitin_synth_2 PF03142.10 CCF46428.1 - 6.2e-31 107.3 0.0 9.3e-26 90.2 0.0 2.4 2 0 0 2 2 2 2 Chitin synthase Glyco_tranf_2_3 PF13641.1 CCF46428.1 - 1.6e-08 34.6 1.4 8.3e-08 32.3 0.6 2.0 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 CCF46428.1 - 1.4e-06 28.1 2.1 3.3e-06 26.9 1.5 1.6 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.21 CCF46428.1 - 0.001 18.8 0.0 1.6 8.3 0.0 2.7 3 0 0 3 3 3 2 Glycosyl transferase family 2 Methyltransf_23 PF13489.1 CCF46429.1 - 1.1e-18 67.5 0.1 1.7e-18 66.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF46429.1 - 1.3e-09 37.8 0.0 1e-08 34.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF46429.1 - 2e-09 37.9 0.0 6.7e-09 36.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF46429.1 - 2.8e-08 34.1 0.0 6.3e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF46429.1 - 1.3e-05 25.5 0.0 4.2e-05 23.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF46429.1 - 6.3e-05 23.2 0.0 0.00016 21.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF46429.1 - 0.00013 21.9 0.0 0.00028 20.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 CCF46429.1 - 0.002 17.5 0.0 0.0037 16.7 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 CCF46429.1 - 0.003 16.9 0.0 0.0048 16.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.14 CCF46429.1 - 0.005 16.8 0.0 0.01 15.8 0.0 1.5 2 0 0 2 2 1 1 FtsJ-like methyltransferase PrmA PF06325.8 CCF46429.1 - 0.008 15.3 0.0 0.013 14.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.15 CCF46429.1 - 0.017 14.2 0.0 0.032 13.3 0.0 1.5 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.12 CCF46429.1 - 0.017 14.1 0.0 0.037 13.0 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Serglycin PF04360.7 CCF46429.1 - 0.12 12.1 0.5 0.18 11.4 0.4 1.2 1 0 0 1 1 1 0 Serglycin Vwaint PF14624.1 CCF46430.1 - 4.2e-33 113.2 0.0 1.6e-32 111.3 0.0 2.0 2 0 0 2 2 2 1 VWA / Hh protein intein-like VWA_2 PF13519.1 CCF46430.1 - 2.8e-11 43.8 0.0 6.1e-11 42.7 0.0 1.5 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.23 CCF46430.1 - 2.2e-09 37.2 0.0 4.5e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.1 CCF46430.1 - 3.4e-06 26.8 0.0 1.3e-05 24.9 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain hNIFK_binding PF12196.3 CCF46432.1 - 0.072 12.4 0.4 0.072 12.4 0.3 3.2 3 0 0 3 3 3 0 FHA Ki67 binding domain of hNIFK Pneumo_phosprot PF02478.11 CCF46433.1 - 1.7 8.0 3.7 0.84 9.1 0.7 1.7 1 1 0 2 2 2 0 Pneumovirus phosphoprotein Myosin_tail_1 PF01576.14 CCF46434.1 - 0.00024 19.0 4.8 0.00024 19.0 3.3 1.0 1 0 0 1 1 1 1 Myosin tail Cwf_Cwc_15 PF04889.7 CCF46434.1 - 0.0067 16.1 2.5 0.0075 16.0 1.7 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Herpes_UL17 PF04559.7 CCF46434.1 - 0.1 11.1 2.3 0.11 11.0 1.6 1.0 1 0 0 1 1 1 0 Herpesvirus UL17 protein IncA PF04156.9 CCF46434.1 - 0.15 11.6 1.8 0.15 11.6 1.3 1.1 1 0 0 1 1 1 0 IncA protein Bap31 PF05529.7 CCF46434.1 - 0.42 10.0 2.3 0.5 9.8 1.6 1.2 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like GrpE PF01025.14 CCF46434.1 - 1.1 8.7 7.9 1.3 8.5 5.4 1.1 1 0 0 1 1 1 0 GrpE DUF3129 PF11327.3 CCF46437.1 - 2.4e-34 118.7 8.6 1.5e-33 116.1 6.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3129) MFS_1 PF07690.11 CCF46438.1 - 7.2e-45 153.2 30.9 1.1e-44 152.6 21.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF46438.1 - 7.7e-12 44.5 10.4 7.7e-12 44.5 7.2 2.3 3 0 0 3 3 3 1 Sugar (and other) transporter Gly-zipper_Omp PF13488.1 CCF46438.1 - 1.3 8.6 4.6 6.5 6.4 0.6 2.7 2 0 0 2 2 2 0 Glycine zipper Period_C PF12114.3 CCF46440.1 - 1.3 8.6 3.3 1.9 8.0 2.3 1.2 1 0 0 1 1 1 0 Period protein 2/3C-terminal region p450 PF00067.17 CCF46441.1 - 2.2e-61 207.8 0.0 3.3e-61 207.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Pro_Al_protease PF02983.9 CCF46442.1 - 0.025 14.5 2.8 0.025 14.5 1.9 3.1 2 2 0 2 2 2 0 Alpha-lytic protease prodomain Cupin_1 PF00190.17 CCF46446.1 - 9.4e-10 38.0 0.2 1.5e-09 37.3 0.2 1.3 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.6 CCF46446.1 - 0.011 15.1 0.0 0.024 14.1 0.0 1.5 1 0 0 1 1 1 0 Cupin domain adh_short PF00106.20 CCF46447.1 - 1.9e-29 102.7 0.0 2.6e-29 102.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF46447.1 - 1.2e-13 51.1 0.0 5.4e-13 49.0 0.0 1.8 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.1 CCF46447.1 - 4.4e-06 26.6 0.0 6.1e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 CCF46447.1 - 0.0014 18.0 0.0 0.0082 15.5 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 CCF46447.1 - 0.0062 15.4 0.0 0.0099 14.8 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein ThiF PF00899.16 CCF46447.1 - 0.037 13.8 0.1 0.062 13.1 0.1 1.5 1 1 0 1 1 1 0 ThiF family Condensation PF00668.15 CCF46448.1 - 5.6e-10 38.5 0.0 6.4e-10 38.3 0.0 1.1 1 0 0 1 1 1 1 Condensation domain ketoacyl-synt PF00109.21 CCF46449.1 - 2.8e-27 95.8 0.0 3.2e-27 95.6 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Glyco_hydro_20 PF00728.17 CCF46450.1 - 0.15 11.2 0.3 0.23 10.5 0.1 1.3 1 1 0 1 1 1 0 Glycosyl hydrolase family 20, catalytic domain MFS_1 PF07690.11 CCF46451.1 - 1.9e-24 86.0 30.6 2.4e-24 85.7 21.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily RGS PF00615.14 CCF46453.1 - 9.5e-12 45.0 0.0 1.3e-11 44.6 0.0 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain DAO PF01266.19 CCF46454.1 - 6.3e-13 48.3 0.5 6.3e-13 48.3 0.4 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase MFS_1 PF07690.11 CCF46455.1 - 0.00033 19.4 4.3 0.00043 19.1 3.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF46455.1 - 0.00058 18.5 5.3 0.00071 18.2 3.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Trp_oprn_chp PF09534.5 CCF46455.1 - 0.035 13.7 2.5 0.045 13.3 1.7 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) ICMT PF04140.9 CCF46455.1 - 0.074 13.2 0.5 16 5.7 0.0 2.5 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF3938 PF13074.1 CCF46455.1 - 0.083 12.7 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3938) TctB PF07331.6 CCF46455.1 - 0.097 12.3 2.4 1.3 8.6 0.0 2.6 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family WD40 PF00400.27 CCF46457.1 - 3.6e-05 23.4 1.3 0.00023 20.9 0.1 2.8 3 0 0 3 3 3 1 WD domain, G-beta repeat ADH_N PF08240.7 CCF46458.1 - 1.1e-25 89.4 2.9 2.3e-25 88.4 2.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF46458.1 - 2.3e-17 62.7 0.0 3.3e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ELFV_dehydrog PF00208.16 CCF46458.1 - 0.0078 15.8 0.3 0.013 15.1 0.2 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ADH_zinc_N_2 PF13602.1 CCF46458.1 - 0.039 14.8 0.0 0.076 13.9 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase SRP-alpha_N PF04086.8 CCF46459.1 - 0.056 12.8 1.5 0.073 12.4 1.0 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal p450 PF00067.17 CCF46463.1 - 3.9e-36 124.5 0.0 4.9e-36 124.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ribosomal_L19 PF01245.15 CCF46464.1 - 3.6e-16 58.9 0.0 5.7e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L19 HpaP PF09483.5 CCF46464.1 - 0.35 10.7 5.5 0.52 10.2 3.8 1.2 1 0 0 1 1 1 0 Type III secretion protein (HpaP) Alpha-amylase PF00128.19 CCF46465.1 - 4.9e-21 75.4 7.6 1.3e-20 74.0 5.3 1.6 1 1 0 1 1 1 1 Alpha amylase, catalytic domain DUF307 PF03733.8 CCF46466.1 - 0.038 14.4 3.0 0.038 14.4 2.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF307) ATP1G1_PLM_MAT8 PF02038.11 CCF46466.1 - 0.22 10.5 0.9 0.32 10.0 0.6 1.2 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family Skp1_POZ PF03931.10 CCF46468.1 - 2.5e-11 43.4 0.0 3.3e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain DEAD PF00270.24 CCF46469.1 - 3.6e-43 146.9 0.0 7.6e-43 145.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.1 CCF46469.1 - 1e-20 73.0 0.2 2.1e-20 71.9 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 CCF46469.1 - 5.8e-20 70.9 0.0 2.8e-19 68.7 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Daxx PF03344.10 CCF46469.1 - 0.49 8.8 19.0 0.67 8.3 13.2 1.1 1 0 0 1 1 1 0 Daxx Family ResIII PF04851.10 CCF46469.1 - 0.79 9.5 7.9 0.27 11.0 0.1 3.0 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit Spore_coat_CotO PF14153.1 CCF46469.1 - 2.1 7.7 11.1 3.4 7.0 7.7 1.3 1 0 0 1 1 1 0 Spore coat protein CotO COPI_C PF06957.6 CCF46469.1 - 3.5 6.0 7.5 6.9 5.0 5.2 1.4 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus Pox_Ag35 PF03286.9 CCF46469.1 - 4.7 6.6 18.3 8.2 5.9 12.7 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein 6PF2K PF01591.13 CCF46471.1 - 1.5e-79 266.2 0.2 2.1e-79 265.7 0.1 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 CCF46471.1 - 5.1e-32 111.1 0.0 1.2e-31 109.9 0.0 1.6 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 CCF46471.1 - 1.4e-09 37.9 0.0 2.4e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.5 CCF46471.1 - 2.2e-05 23.8 0.1 3.3e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.1 CCF46471.1 - 0.00044 21.0 1.2 0.0038 18.0 0.1 2.7 2 1 0 2 2 2 1 AAA domain Asp PF00026.18 CCF46472.1 - 1.5e-39 136.1 0.3 2e-39 135.7 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.1 CCF46472.1 - 2.7e-07 30.9 0.2 0.012 16.0 0.0 3.5 3 0 0 3 3 3 2 Aspartyl protease TAXi_C PF14541.1 CCF46472.1 - 0.0002 20.9 0.1 0.0047 16.4 0.0 2.8 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal RVP PF00077.15 CCF46472.1 - 0.009 15.9 0.0 0.093 12.6 0.0 2.3 2 0 0 2 2 2 1 Retroviral aspartyl protease Helicase_C PF00271.26 CCF46475.1 - 0.0029 17.4 0.0 0.0054 16.5 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Lipase_3 PF01764.20 CCF46476.1 - 1.7e-22 79.5 0.1 2.6e-22 78.9 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 CCF46476.1 - 0.0021 17.8 0.1 0.0033 17.1 0.1 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF46476.1 - 0.0042 16.9 0.3 0.0042 16.9 0.2 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_8 PF06259.7 CCF46476.1 - 0.012 15.1 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase Thioesterase PF00975.15 CCF46476.1 - 0.021 15.0 0.0 0.038 14.2 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain Cutinase PF01083.17 CCF46476.1 - 0.063 13.0 0.7 0.17 11.6 0.5 1.8 1 1 0 1 1 1 0 Cutinase ETF_QO PF05187.8 CCF46477.1 - 5.3e-46 155.1 0.0 8.4e-46 154.5 0.0 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase DAO PF01266.19 CCF46477.1 - 0.0023 16.9 0.0 0.048 12.5 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Fer4_7 PF12838.2 CCF46477.1 - 0.011 16.1 0.9 0.03 14.7 0.7 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain HIG_1_N PF04588.8 CCF46481.1 - 6.9e-08 32.1 2.3 1.2e-07 31.3 1.6 1.4 1 0 0 1 1 1 1 Hypoxia induced protein conserved region ubiquitin PF00240.18 CCF46482.1 - 2.2e-19 68.6 0.1 2.8e-19 68.2 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 CCF46482.1 - 2.7e-05 23.7 0.1 3.5e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.1 CCF46482.1 - 7.6e-05 22.5 0.0 9.4e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 CCF46482.1 - 0.013 15.6 0.0 0.016 15.4 0.0 1.1 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_2 PF14560.1 CCF46482.1 - 0.078 13.2 0.1 0.54 10.5 0.1 2.0 1 1 0 1 1 1 0 Ubiquitin-like domain CDP-OH_P_transf PF01066.16 CCF46484.1 - 1.3e-15 57.5 3.0 2.4e-15 56.6 2.1 1.4 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase DUF1767 PF08585.7 CCF46485.1 - 2.9e-07 30.6 0.1 6.1e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1767) Dynamin_N PF00350.18 CCF46490.1 - 6.2e-29 100.9 0.0 1.2e-28 100.0 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 CCF46490.1 - 2.3e-15 56.1 0.0 5.7e-14 51.5 0.0 2.3 1 1 1 2 2 2 1 Dynamin central region GED PF02212.13 CCF46490.1 - 8e-06 25.6 0.7 2.9e-05 23.8 0.5 2.0 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 CCF46490.1 - 0.00014 21.7 0.0 0.00052 19.9 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CCF46490.1 - 0.0088 16.5 0.0 0.043 14.3 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein AAA_21 PF13304.1 CCF46490.1 - 0.013 15.4 0.0 0.029 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.13 CCF46490.1 - 0.11 11.7 0.0 9.3 5.5 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_23 PF13476.1 CCF46490.1 - 0.14 12.4 0.1 0.45 10.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain CN_hydrolase PF00795.17 CCF46491.1 - 1e-21 77.1 0.0 1.4e-21 76.6 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF1471 PF07338.8 CCF46491.1 - 0.3 10.7 2.4 2.1 8.0 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1471) CAV_VP3 PF04771.7 CCF46492.1 - 0.011 15.7 0.0 0.012 15.6 0.0 1.1 1 0 0 1 1 1 0 Chicken anaemia virus VP-3 protein HET PF06985.6 CCF46494.1 - 3.3e-22 79.1 0.0 6.3e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) PQQ_2 PF13360.1 CCF46495.1 - 0.01 15.2 3.4 0.032 13.6 2.4 1.9 1 1 0 1 1 1 0 PQQ-like domain SGL PF08450.7 CCF46495.1 - 0.035 13.4 0.0 0.049 13.0 0.0 1.2 1 0 0 1 1 1 0 SMP-30/Gluconolaconase/LRE-like region ThiF PF00899.16 CCF46497.1 - 0.094 12.5 0.1 0.13 12.0 0.1 1.2 1 0 0 1 1 1 0 ThiF family F420_oxidored PF03807.12 CCF46497.1 - 0.098 13.0 0.0 0.22 11.9 0.0 1.6 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 CCF46497.1 - 0.12 12.5 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Cys_Met_Meta_PP PF01053.15 CCF46499.1 - 1.2e-142 474.8 0.0 1.3e-142 474.6 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 CCF46499.1 - 7.8e-11 41.6 0.1 1e-09 37.9 0.1 2.1 2 1 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 CCF46499.1 - 6.4e-09 35.2 0.1 9.1e-09 34.7 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 CCF46499.1 - 1.3e-07 30.7 0.1 2.3e-07 29.8 0.1 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 CCF46499.1 - 5e-05 22.5 0.1 0.00012 21.3 0.0 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase SLA_LP_auto_ag PF05889.8 CCF46499.1 - 0.0027 16.2 0.1 0.004 15.6 0.1 1.1 1 0 0 1 1 1 1 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) GDC-P PF02347.11 CCF46499.1 - 0.0038 15.9 0.0 0.0051 15.5 0.0 1.1 1 0 0 1 1 1 1 Glycine cleavage system P-protein Met_gamma_lyase PF06838.6 CCF46499.1 - 0.012 13.8 0.0 0.016 13.4 0.0 1.2 1 0 0 1 1 1 0 Methionine gamma-lyase ADH_zinc_N PF00107.21 CCF46499.1 - 0.026 14.0 0.0 0.06 12.8 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Pyridoxal_deC PF00282.14 CCF46499.1 - 0.13 10.6 0.1 0.27 9.6 0.0 1.5 2 0 0 2 2 2 0 Pyridoxal-dependent decarboxylase conserved domain Cerato-platanin PF07249.7 CCF46501.1 - 3.4e-31 107.7 0.2 3.7e-31 107.6 0.1 1.0 1 0 0 1 1 1 1 Cerato-platanin Glyco_hydro_18 PF00704.23 CCF46502.1 - 2.4e-70 237.6 0.0 2.9e-70 237.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF3142 PF11340.3 CCF46502.1 - 4.9e-05 23.0 0.0 7.5e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3142) CDC27 PF09507.5 CCF46503.1 - 0.77 8.9 15.1 0.99 8.5 10.5 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 zf-UBR PF02207.15 CCF46504.1 - 2e-17 62.6 4.3 3.1e-17 62.0 3.0 1.3 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) DHODB_Fe-S_bind PF10418.4 CCF46504.1 - 1.3 8.5 8.8 1.1 8.7 3.6 2.3 1 1 1 2 2 2 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B PH_10 PF15411.1 CCF46505.1 - 1.1e-25 90.0 0.2 1.9e-25 89.3 0.1 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain VWA_3 PF13768.1 CCF46505.1 - 4.7e-10 39.3 0.0 1.1e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 CCF46505.1 - 4.8e-08 32.9 0.0 8.6e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain zf-RING_2 PF13639.1 CCF46505.1 - 6.7e-07 29.0 5.9 1.3e-06 28.1 4.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 CCF46505.1 - 0.003 17.2 5.1 0.0051 16.5 3.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.2 CCF46505.1 - 0.0077 16.3 1.1 0.016 15.3 0.8 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING-like PF08746.6 CCF46505.1 - 0.089 12.8 4.2 0.15 12.0 2.9 1.4 1 0 0 1 1 1 0 RING-like domain zf-C3HC4_2 PF13923.1 CCF46505.1 - 0.097 12.7 5.0 0.17 11.9 3.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF46505.1 - 0.13 11.9 5.5 0.23 11.1 3.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1147 PF06615.6 CCF46505.1 - 0.14 12.0 0.5 0.36 10.6 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1147) HET PF06985.6 CCF46506.1 - 5.3e-09 36.3 0.0 7.6e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) TSP9 PF11493.3 CCF46507.1 - 0.051 14.1 0.2 0.066 13.7 0.2 1.1 1 0 0 1 1 1 0 Thylakoid soluble phosphoprotein TSP9 Fungal_trans PF04082.13 CCF46511.1 - 0.00016 20.6 0.1 0.00036 19.4 0.1 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Condensation PF00668.15 CCF46512.1 - 6.1e-20 71.2 0.0 1.4e-19 70.0 0.0 1.6 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.20 CCF46512.1 - 5.3e-05 23.4 0.0 0.0001 22.4 0.0 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.1 CCF46512.1 - 0.00031 21.6 0.0 0.00092 20.1 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain YEATS PF03366.11 CCF46513.1 - 1.9e-24 85.1 0.1 3.3e-24 84.4 0.1 1.4 1 0 0 1 1 1 1 YEATS family YidC_periplas PF14849.1 CCF46513.1 - 0.022 14.6 0.1 0.029 14.2 0.1 1.2 1 0 0 1 1 1 0 YidC periplasmic domain MgtE_N PF03448.12 CCF46513.1 - 0.041 14.2 0.1 0.081 13.2 0.1 1.5 1 0 0 1 1 1 0 MgtE intracellular N domain DUF953 PF06110.6 CCF46515.1 - 7.6e-19 67.3 0.1 9.3e-19 67.0 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin PF00085.15 CCF46515.1 - 0.0012 18.5 0.3 0.0024 17.5 0.2 1.6 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.1 CCF46515.1 - 0.04 13.4 0.0 0.065 12.7 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin Vac7 PF12751.2 CCF46516.1 - 2.5e-122 408.5 4.5 4.5e-122 407.6 3.1 1.4 1 0 0 1 1 1 1 Vacuolar segregation subunit 7 Daxx PF03344.10 CCF46519.1 - 2.7 6.3 19.4 5.4 5.3 13.4 1.4 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 CCF46519.1 - 3.5 5.4 30.7 0.014 13.3 14.6 1.7 2 0 0 2 2 2 0 Nop14-like family eIF-3c_N PF05470.7 CCF46519.1 - 3.8 5.5 13.4 7.5 4.5 9.3 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus SURF2 PF05477.6 CCF46519.1 - 4.4 6.3 24.7 6.6 5.7 11.5 2.5 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) CDC45 PF02724.9 CCF46519.1 - 5.2 4.9 23.2 0.065 11.2 10.8 1.5 2 0 0 2 2 2 0 CDC45-like protein Dioxygenase_C PF00775.16 CCF46520.1 - 2.4e-11 43.2 0.1 4.2e-11 42.4 0.1 1.4 1 0 0 1 1 1 1 Dioxygenase Phosphodiest PF01663.17 CCF46521.1 - 5.4e-15 55.5 0.2 5.4e-15 55.5 0.1 1.7 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 CCF46521.1 - 2.3e-07 30.3 0.0 5.3e-07 29.1 0.0 1.8 1 1 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.13 CCF46521.1 - 1.3e-05 24.7 1.0 2e-05 24.0 0.7 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily adh_short PF00106.20 CCF46522.1 - 4.8e-30 104.6 2.1 6.4e-30 104.2 1.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF46522.1 - 8.8e-19 68.2 0.3 1.1e-18 67.8 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF46522.1 - 1.5e-13 50.7 1.2 2.1e-13 50.3 0.8 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CCF46522.1 - 2.4e-07 30.9 0.9 3.4e-07 30.4 0.6 1.4 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF46522.1 - 0.00028 20.3 0.2 0.00054 19.4 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 CCF46522.1 - 0.004 16.4 0.2 0.0057 15.9 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family TrkA_N PF02254.13 CCF46522.1 - 0.0087 16.0 0.1 0.025 14.5 0.0 1.7 2 0 0 2 2 2 1 TrkA-N domain NAD_Gly3P_dh_N PF01210.18 CCF46522.1 - 0.035 13.8 0.0 0.071 12.8 0.0 1.5 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Shikimate_DH PF01488.15 CCF46522.1 - 0.043 13.9 0.6 0.069 13.2 0.0 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase PP2C_2 PF13672.1 CCF46522.1 - 0.057 12.8 0.5 0.085 12.2 0.4 1.2 1 0 0 1 1 1 0 Protein phosphatase 2C MFS_1 PF07690.11 CCF46523.1 - 3.1e-17 62.3 44.6 3.1e-17 62.3 30.9 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily SH3_1 PF00018.23 CCF46524.1 - 3.1e-16 58.4 1.8 1e-12 47.2 0.4 2.2 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.1 CCF46524.1 - 1.8e-15 56.2 0.9 8.8e-14 50.8 0.2 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.12 CCF46524.1 - 5.1e-12 45.0 0.0 2.3e-10 39.7 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain F420_ligase PF01996.11 CCF46524.1 - 0.081 11.9 0.0 0.091 11.8 0.0 1.4 1 1 0 1 1 1 0 F420-0:Gamma-glutamyl ligase SH3_3 PF08239.6 CCF46524.1 - 0.11 12.7 0.1 0.15 12.2 0.1 1.2 1 0 0 1 1 1 0 Bacterial SH3 domain A_deaminase PF00962.17 CCF46525.1 - 6.6e-111 370.3 0.1 8.6e-111 370.0 0.1 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase UAA PF08449.6 CCF46526.1 - 2.3e-75 253.3 0.2 6.3e-73 245.3 0.1 2.2 1 1 0 1 1 1 1 UAA transporter family TPT PF03151.11 CCF46526.1 - 0.0084 15.7 2.8 0.025 14.2 1.5 2.1 2 0 0 2 2 2 1 Triose-phosphate Transporter family WD40 PF00400.27 CCF46527.1 - 1.2e-12 47.1 1.6 0.89 9.5 0.1 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat FOLN PF09289.5 CCF46529.1 - 0.004 16.9 1.7 0.0078 16.0 1.2 1.5 1 0 0 1 1 1 1 Follistatin/Osteonectin-like EGF domain CD99L2 PF12301.3 CCF46529.1 - 0.15 11.7 0.3 0.26 10.9 0.2 1.5 1 0 0 1 1 1 0 CD99 antigen like protein 2 NifU_N PF01592.11 CCF46530.1 - 0.029 14.3 0.0 0.029 14.2 0.0 1.1 1 0 0 1 1 1 0 NifU-like N terminal domain DUF1751 PF08551.5 CCF46534.1 - 0.077 13.3 0.1 0.19 12.0 0.1 1.7 1 0 0 1 1 1 0 Eukaryotic integral membrane protein (DUF1751) Coprogen_oxidas PF01218.13 CCF46537.1 - 3.6e-115 383.5 0.1 4.6e-115 383.2 0.1 1.1 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase DUF1651 PF07864.6 CCF46537.1 - 0.078 13.0 0.1 0.22 11.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1651) TauD PF02668.11 CCF46540.1 - 8.2e-28 97.7 0.0 1.5e-27 96.9 0.0 1.4 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family SUZ-C PF12901.2 CCF46540.1 - 0.0078 15.8 0.1 0.017 14.7 0.1 1.5 1 0 0 1 1 1 1 SUZ-C motif ABC_tran PF00005.22 CCF46541.1 - 1.2e-50 171.3 0.0 3.4e-24 85.6 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC2_membrane PF01061.19 CCF46541.1 - 8.3e-50 168.8 32.1 1.4e-28 99.5 7.0 3.0 3 0 0 3 3 3 2 ABC-2 type transporter AAA_21 PF13304.1 CCF46541.1 - 2.2e-21 77.0 0.4 4e-07 30.2 0.0 3.8 3 1 0 3 3 3 3 AAA domain DUF258 PF03193.11 CCF46541.1 - 2.8e-09 36.3 0.6 0.0021 17.2 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_23 PF13476.1 CCF46541.1 - 1.3e-08 35.4 0.7 0.00028 21.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 CCF46541.1 - 1.4e-08 34.1 2.1 0.0038 16.7 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 CCF46541.1 - 1.9e-08 34.4 0.2 0.0045 16.9 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.14 CCF46541.1 - 4.2e-08 32.6 0.7 0.00076 18.7 0.0 3.8 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.1 CCF46541.1 - 1.1e-07 31.4 0.2 0.016 14.6 0.0 3.5 4 0 0 4 4 3 2 AAA domain AAA_15 PF13175.1 CCF46541.1 - 1.5e-07 30.7 0.0 0.68 8.9 0.0 4.1 4 0 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.1 CCF46541.1 - 4e-07 30.2 1.1 0.0051 16.9 0.0 3.2 3 2 0 3 3 2 2 AAA domain NACHT PF05729.7 CCF46541.1 - 8.5e-06 25.5 0.1 0.16 11.6 0.0 2.4 2 0 0 2 2 2 2 NACHT domain T2SE PF00437.15 CCF46541.1 - 1.6e-05 23.9 0.2 0.14 11.0 0.0 2.2 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_17 PF13207.1 CCF46541.1 - 1.8e-05 25.5 0.0 0.33 11.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_10 PF12846.2 CCF46541.1 - 2.3e-05 23.9 2.7 0.03 13.7 0.2 2.4 2 0 0 2 2 2 2 AAA-like domain AAA_19 PF13245.1 CCF46541.1 - 2.6e-05 23.8 0.2 0.076 12.7 0.0 2.7 2 0 0 2 2 2 2 Part of AAA domain PDR_CDR PF06422.7 CCF46541.1 - 2.7e-05 23.7 0.1 6.5e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 CDR ABC transporter AAA_28 PF13521.1 CCF46541.1 - 3.5e-05 23.8 1.4 0.084 12.8 0.4 2.6 2 0 0 2 2 2 2 AAA domain FtsK_SpoIIIE PF01580.13 CCF46541.1 - 5.4e-05 22.7 1.6 0.036 13.5 0.1 2.7 2 0 0 2 2 2 2 FtsK/SpoIIIE family SbcCD_C PF13558.1 CCF46541.1 - 5.7e-05 22.9 0.8 0.68 9.8 0.0 3.6 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit Arch_ATPase PF01637.13 CCF46541.1 - 0.00023 20.9 0.0 0.18 11.4 0.0 2.4 2 0 0 2 2 2 1 Archaeal ATPase AAA_18 PF13238.1 CCF46541.1 - 0.00025 21.3 0.0 1.1 9.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.1 CCF46541.1 - 0.00045 19.8 0.0 0.9 9.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain cobW PF02492.14 CCF46541.1 - 0.00064 19.2 3.1 0.54 9.6 0.4 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.12 CCF46541.1 - 0.00099 18.7 0.2 0.59 9.6 0.1 2.8 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_33 PF13671.1 CCF46541.1 - 0.0022 17.9 0.0 1.9 8.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain PDR_assoc PF08370.6 CCF46541.1 - 0.0022 17.4 0.1 0.01 15.3 0.0 2.1 1 0 0 1 1 1 1 Plant PDR ABC transporter associated MMR_HSR1 PF01926.18 CCF46541.1 - 0.0023 17.8 1.9 1 9.3 0.1 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase RNA_helicase PF00910.17 CCF46541.1 - 0.0024 18.0 0.1 1.9 8.7 0.0 2.6 2 0 0 2 2 2 1 RNA helicase PduV-EutP PF10662.4 CCF46541.1 - 0.0028 17.1 0.4 1.5 8.2 0.1 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Miro PF08477.8 CCF46541.1 - 0.003 18.0 0.1 4.7 7.7 0.0 2.5 2 0 0 2 2 2 0 Miro-like protein ABC_ATPase PF09818.4 CCF46541.1 - 0.0031 16.1 0.1 0.97 7.9 0.1 3.3 4 0 0 4 4 3 1 Predicted ATPase of the ABC class NTPase_1 PF03266.10 CCF46541.1 - 0.0033 17.1 0.3 1.6 8.4 0.0 3.7 4 0 0 4 4 4 1 NTPase AAA_24 PF13479.1 CCF46541.1 - 0.0033 17.0 0.4 2.5 7.6 0.2 2.3 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 CCF46541.1 - 0.0035 17.0 0.2 3.1 7.5 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B UPF0079 PF02367.12 CCF46541.1 - 0.0039 16.8 0.2 3.3 7.3 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Zeta_toxin PF06414.7 CCF46541.1 - 0.0048 16.0 0.2 3.2 6.7 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_14 PF13173.1 CCF46541.1 - 0.0095 15.8 0.1 3.9 7.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain Pox_A32 PF04665.7 CCF46541.1 - 0.016 14.5 0.9 0.53 9.5 0.1 2.5 2 0 0 2 2 2 0 Poxvirus A32 protein IstB_IS21 PF01695.12 CCF46541.1 - 0.017 14.5 2.4 0.63 9.4 0.0 3.3 4 0 0 4 4 3 0 IstB-like ATP binding protein AAA_5 PF07728.9 CCF46541.1 - 0.021 14.5 0.4 4.8 6.9 0.0 2.8 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) Septin PF00735.13 CCF46541.1 - 0.029 13.3 0.3 1.4 7.8 0.1 2.2 2 0 0 2 2 2 0 Septin PhoH PF02562.11 CCF46541.1 - 0.032 13.4 0.3 1.4 8.1 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein ATP-synt_ab PF00006.20 CCF46541.1 - 0.063 12.7 0.0 4.4 6.7 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain SRPRB PF09439.5 CCF46541.1 - 0.085 12.0 0.6 4.1 6.5 0.0 2.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA PF00004.24 CCF46541.1 - 0.1 12.8 0.4 4.6 7.4 0.0 3.1 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) KAP_NTPase PF07693.9 CCF46541.1 - 0.11 11.4 0.0 9.6 5.0 0.0 2.2 2 0 0 2 2 2 0 KAP family P-loop domain PRK PF00485.13 CCF46541.1 - 0.12 11.8 0.3 3.8 7.0 0.0 2.2 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family ABC2_membrane_3 PF12698.2 CCF46541.1 - 0.34 9.9 28.5 0.6 9.0 10.4 2.3 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF2075 PF09848.4 CCF46541.1 - 0.4 9.5 0.1 23 3.8 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Dynamin_N PF00350.18 CCF46541.1 - 0.44 10.3 1.1 21 4.8 0.1 2.7 3 0 0 3 3 2 0 Dynamin family DUF87 PF01935.12 CCF46541.1 - 0.84 9.4 3.0 1.3 8.8 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF87 DUF3987 PF13148.1 CCF46541.1 - 4 5.9 4.6 22 3.4 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3987) Sds3 PF08598.6 CCF46543.1 - 0.25 10.8 8.8 0.23 10.9 3.3 2.1 2 0 0 2 2 2 0 Sds3-like DDE_1 PF03184.14 CCF46547.1 - 3.6e-20 72.0 0.0 7.8e-20 70.9 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 CCF46547.1 - 1.4e-06 28.0 0.6 3.4e-06 26.7 0.1 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain Amidohydro_1 PF01979.15 CCF46548.1 - 4.1e-33 115.4 0.0 5.5e-33 115.0 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 CCF46548.1 - 1.6e-09 37.4 0.1 3.3e-06 26.5 0.0 3.1 2 2 1 3 3 3 2 Amidohydrolase family Amidohydro_4 PF13147.1 CCF46548.1 - 1.3e-06 28.7 0.0 0.021 14.8 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase Amidohydro_5 PF13594.1 CCF46548.1 - 1.9e-05 24.3 0.0 5.3e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 Amidohydrolase A_deaminase PF00962.17 CCF46548.1 - 0.005 15.7 0.0 0.0097 14.8 0.0 1.4 1 0 0 1 1 1 1 Adenosine/AMP deaminase YlbD_coat PF14071.1 CCF46548.1 - 0.063 13.3 0.0 0.83 9.7 0.0 2.2 2 0 0 2 2 2 0 Putative coat protein APH PF01636.18 CCF46550.1 - 0.00012 21.8 0.0 0.00023 21.0 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family GRAM PF02893.15 CCF46551.1 - 1.3e-26 91.9 0.4 9.5e-15 53.8 0.0 3.4 3 0 0 3 3 3 3 GRAM domain Glyco_transf_28 PF03033.15 CCF46551.1 - 3.1e-25 88.5 0.0 6.8e-25 87.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain PH PF00169.24 CCF46551.1 - 2.9e-14 53.1 0.0 1.1e-13 51.2 0.0 2.1 1 0 0 1 1 1 1 PH domain PH_8 PF15409.1 CCF46551.1 - 0.00012 22.1 0.2 0.00048 20.1 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.1 CCF46551.1 - 0.00012 22.2 0.3 0.00012 22.2 0.2 2.7 2 1 0 2 2 2 1 Pleckstrin homology domain UDPGT PF00201.13 CCF46551.1 - 0.00097 17.8 0.1 0.0036 15.9 0.1 1.8 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_6 PF15406.1 CCF46551.1 - 0.026 14.5 0.6 0.21 11.6 0.0 2.7 2 0 0 2 2 2 0 Pleckstrin homology domain RAB3GAP2_N PF14655.1 CCF46551.1 - 0.15 11.0 1.4 0.28 10.1 1.0 1.4 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF3504 PF12012.3 CCF46551.1 - 2.2 7.9 11.9 1.6 8.4 0.9 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3504) NIF PF03031.13 CCF46552.1 - 1e-27 96.7 0.1 3.2e-27 95.1 0.0 1.9 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.2 CCF46552.1 - 1.1e-08 34.8 0.3 3.6e-08 33.1 0.0 2.1 2 0 0 2 2 2 1 twin BRCT domain BRCT PF00533.21 CCF46552.1 - 7.5e-08 32.4 0.0 2.4e-07 30.7 0.0 1.8 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Biotin_lipoyl PF00364.17 CCF46552.1 - 0.034 13.7 0.0 5 6.8 0.0 2.7 2 0 0 2 2 2 0 Biotin-requiring enzyme Ribosomal_S2 PF00318.15 CCF46552.1 - 0.12 11.6 0.0 0.36 10.0 0.0 1.8 2 0 0 2 2 2 0 Ribosomal protein S2 Zn_clus PF00172.13 CCF46553.1 - 1.2e-06 28.3 5.9 1.8e-06 27.7 4.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CCF46553.1 - 2.4e-05 23.3 0.4 3.4e-05 22.8 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Swi3 PF07962.7 CCF46554.1 - 8.8e-29 98.9 0.5 4.2e-28 96.7 0.2 2.1 2 0 0 2 2 2 1 Replication Fork Protection Component Swi3 PALP PF00291.20 CCF46555.1 - 1.6e-24 86.6 0.2 2.1e-24 86.3 0.2 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme MurB_C PF02873.11 CCF46555.1 - 0.063 13.0 0.0 0.098 12.4 0.0 1.3 1 0 0 1 1 1 0 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain Dicty_REP PF05086.7 CCF46556.1 - 9.5 3.8 5.9 10 3.7 4.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Peptidase_S8 PF00082.17 CCF46557.1 - 8.1e-16 58.0 1.1 1.5e-15 57.1 0.1 1.7 2 0 0 2 2 2 1 Subtilase family Inhibitor_I9 PF05922.11 CCF46557.1 - 0.00048 20.6 0.1 0.0008 19.9 0.1 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 p450 PF00067.17 CCF46558.1 - 2.2e-11 42.9 0.0 2.8e-11 42.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 JmjC PF02373.17 CCF46559.1 - 0.077 13.2 0.1 0.081 13.1 0.1 1.0 1 0 0 1 1 1 0 JmjC domain, hydroxylase GCS PF03074.11 CCF46560.1 - 4e-30 105.0 0.0 4.5e-30 104.9 0.0 1.0 1 0 0 1 1 1 1 Glutamate-cysteine ligase Crystall_3 PF08964.5 CCF46561.1 - 9.7e-08 31.6 0.1 0.00024 20.7 0.0 2.1 1 1 1 2 2 2 2 Beta/Gamma crystallin Crystall PF00030.14 CCF46561.1 - 0.0015 18.3 0.2 0.0021 17.9 0.1 1.1 1 0 0 1 1 1 1 Beta/Gamma crystallin DIM PF08194.7 CCF46561.1 - 0.014 15.3 0.8 0.023 14.6 0.5 1.4 1 0 0 1 1 1 0 DIM protein AAA PF00004.24 CCF46562.1 - 6.8e-17 61.9 0.0 1.3e-16 61.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CCF46562.1 - 0.023 14.8 0.0 0.049 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mito_fiss_reg PF05308.6 CCF46562.1 - 0.036 13.4 1.1 0.051 12.9 0.8 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.14 CCF46562.1 - 2.9 7.1 4.3 4.2 6.5 3.0 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Isochorismatase PF00857.15 CCF46563.1 - 6.5e-31 107.6 0.2 8e-31 107.2 0.1 1.1 1 0 0 1 1 1 1 Isochorismatase family TPP_enzyme_M PF00205.17 CCF46563.1 - 0.044 13.5 0.1 0.64 9.7 0.0 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain HK PF02110.10 CCF46564.1 - 3.4e-49 167.2 0.2 4.5e-49 166.8 0.1 1.0 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family Carb_kinase PF01256.12 CCF46564.1 - 0.0004 19.7 0.1 0.00058 19.2 0.1 1.3 1 1 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.7 CCF46564.1 - 0.0024 17.1 0.0 0.0031 16.7 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Zn_clus PF00172.13 CCF46566.1 - 0.00013 21.8 2.6 0.00022 21.0 0.6 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PRP4 PF08799.6 CCF46568.1 - 2.7e-11 42.5 3.2 2.7e-11 42.5 2.2 2.8 3 0 0 3 3 3 1 pre-mRNA processing factor 4 (PRP4) like Borrelia_P83 PF05262.6 CCF46568.1 - 0.0046 15.2 10.3 0.0042 15.4 7.1 1.1 1 0 0 1 1 1 1 Borrelia P83/100 protein CDC27 PF09507.5 CCF46568.1 - 0.017 14.4 15.0 0.023 13.9 10.4 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Ycf1 PF05758.7 CCF46568.1 - 1 7.0 5.6 0.98 7.0 3.9 1.1 1 0 0 1 1 1 0 Ycf1 Presenilin PF01080.12 CCF46568.1 - 5.2 5.7 8.3 7.5 5.2 5.7 1.2 1 0 0 1 1 1 0 Presenilin HTH_psq PF05225.11 CCF46570.1 - 1.3e-11 43.8 0.0 3.2e-11 42.5 0.0 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF46570.1 - 3.2e-07 30.0 0.0 7.2e-07 28.9 0.0 1.6 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 CCF46570.1 - 1.1e-05 24.6 0.0 1.8e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease MFS_1 PF07690.11 CCF46572.1 - 6.6e-28 97.4 29.1 6.6e-28 97.4 20.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily YebO PF13974.1 CCF46572.1 - 0.2 11.4 0.2 2.9 7.7 0.0 2.2 2 0 0 2 2 2 0 YebO-like protein Sugar_tr PF00083.19 CCF46572.1 - 0.23 10.0 22.1 0.034 12.7 10.0 2.7 2 1 0 2 2 2 0 Sugar (and other) transporter Atg14 PF10186.4 CCF46573.1 - 7.3e-76 254.9 0.0 8.6e-76 254.7 0.0 1.0 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 AIP3 PF03915.8 CCF46573.1 - 0.0063 15.4 0.4 0.0087 15.0 0.3 1.1 1 0 0 1 1 1 1 Actin interacting protein 3 IpaC_SipC PF09599.5 CCF46573.1 - 0.022 13.7 9.2 0.046 12.7 6.4 1.4 1 1 0 1 1 1 0 Salmonella-Shigella invasin protein C (IpaC_SipC) Glyco_hydro_88 PF07470.8 CCF46575.1 - 2.4e-84 283.2 0.6 2.8e-84 283.0 0.4 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 TAFH PF07531.9 CCF46575.1 - 0.056 13.0 0.1 1.5 8.5 0.0 2.2 2 0 0 2 2 2 0 NHR1 homology to TAF Glyco_hydro_76 PF03663.9 CCF46575.1 - 0.32 10.3 5.8 0.049 13.0 0.7 2.0 2 1 1 3 3 3 0 Glycosyl hydrolase family 76 MFS_1 PF07690.11 CCF46576.1 - 1.1e-35 123.0 23.2 1.5e-35 122.5 16.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2929 PF11151.3 CCF46576.1 - 0.14 12.2 0.0 0.14 12.2 0.0 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF2929) ESSS PF10183.4 CCF46576.1 - 2.8 8.3 6.0 6.6 7.1 0.1 3.4 2 1 1 3 3 3 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) BMF PF15185.1 CCF46577.1 - 0.05 12.9 0.0 0.055 12.7 0.0 1.1 1 0 0 1 1 1 0 Bcl-2-modifying factor, apoptosis EI24 PF07264.6 CCF46578.1 - 5.3 6.3 10.5 0.1 12.0 0.3 2.1 1 1 1 2 2 2 0 Etoposide-induced protein 2.4 (EI24) Gp_dh_C PF02800.15 CCF46579.1 - 8.6e-67 223.4 0.2 9.9e-67 223.2 0.1 1.0 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Fungal_trans PF04082.13 CCF46581.1 - 3.1e-06 26.2 0.0 5.2e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain FtsX PF02687.16 CCF46582.1 - 3.9 7.2 12.0 0.66 9.7 0.8 3.3 3 0 0 3 3 3 0 FtsX-like permease family BHD_2 PF10404.4 CCF46583.1 - 0.1 12.9 0.2 0.1 12.9 0.1 2.1 2 1 0 2 2 2 0 Rad4 beta-hairpin domain 2 DUF4455 PF14643.1 CCF46583.1 - 1.1 7.8 5.4 1.5 7.3 3.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4455) Aconitase PF00330.15 CCF46584.1 - 6.3e-61 206.2 0.0 1e-38 133.0 0.0 2.2 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 CCF46584.1 - 3.3e-15 56.3 0.0 9.2e-15 54.9 0.0 1.7 2 0 0 2 2 2 1 Aconitase C-terminal domain p450 PF00067.17 CCF46585.1 - 1.2e-61 208.6 0.0 1.8e-61 208.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short_C2 PF13561.1 CCF46585.1 - 2.9e-06 27.2 0.0 7.5e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase CBFD_NFYB_HMF PF00808.18 CCF46586.1 - 1.7e-12 47.1 0.0 3e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 CCF46586.1 - 0.0077 16.3 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 MBOAT PF03062.14 CCF46587.1 - 3e-34 118.5 19.5 8.6e-34 117.1 13.5 1.7 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Cytochrom_B561 PF03188.11 CCF46587.1 - 0.0065 16.2 1.1 0.013 15.3 0.8 1.5 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 MBOAT_2 PF13813.1 CCF46587.1 - 0.42 10.7 10.1 0.64 10.1 3.9 2.9 2 1 0 2 2 2 0 Membrane bound O-acyl transferase family DUF2566 PF10753.4 CCF46588.1 - 0.13 12.2 0.3 0.18 11.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2566) PDGLE PF13190.1 CCF46588.1 - 0.13 11.9 1.9 0.46 10.1 0.9 1.9 2 0 0 2 2 2 0 PDGLE domain Dioxygenase_C PF00775.16 CCF46589.1 - 1.8e-42 144.6 0.0 2.4e-42 144.2 0.0 1.1 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.9 CCF46589.1 - 9.5e-13 47.9 0.0 1.5e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.1 CCF46589.1 - 0.0079 16.2 0.0 0.037 14.0 0.0 2.1 1 1 0 1 1 1 1 Carboxypeptidase regulatory-like domain p450 PF00067.17 CCF46590.1 - 7.2e-48 163.2 0.0 7.9e-48 163.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Proteasome PF00227.21 CCF46591.1 - 2.8e-51 173.5 0.0 2.4e-27 95.4 0.0 2.1 2 0 0 2 2 2 2 Proteasome subunit DUF3451 PF11933.3 CCF46592.1 - 0.0053 16.5 0.5 0.0053 16.5 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3451) SpaB_C PF14028.1 CCF46592.1 - 0.2 11.2 2.0 0.24 10.9 1.4 1.0 1 0 0 1 1 1 0 SpaB C-terminal domain Spore_coat_CotO PF14153.1 CCF46592.1 - 0.66 9.3 4.9 0.83 9.0 3.4 1.2 1 0 0 1 1 1 0 Spore coat protein CotO DUF2130 PF09903.4 CCF46592.1 - 0.69 8.6 6.5 0.85 8.2 4.5 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2130) zf-H2C2_2 PF13465.1 CCF46593.1 - 3.6e-13 49.1 6.0 2.3e-05 24.4 0.0 4.1 4 1 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.21 CCF46593.1 - 5.1e-13 48.5 15.4 6.8e-05 22.9 1.1 3.6 3 1 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CCF46593.1 - 3.8e-12 45.6 12.6 2e-05 24.5 0.9 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CCF46593.1 - 8.5e-09 35.3 2.4 0.059 13.5 0.1 3.6 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CCF46593.1 - 3.5e-08 33.3 3.3 0.006 16.7 0.1 3.5 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-Di19 PF05605.7 CCF46593.1 - 0.012 15.7 1.1 0.027 14.5 0.8 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Endonuclease_7 PF02945.10 CCF46593.1 - 0.013 15.1 1.0 0.024 14.3 0.7 1.4 1 0 0 1 1 1 0 Recombination endonuclease VII LIM PF00412.17 CCF46593.1 - 0.025 14.6 3.9 2.9 8.0 2.8 2.7 1 1 1 2 2 2 0 LIM domain Zn_ribbon_recom PF13408.1 CCF46593.1 - 0.056 13.7 1.0 0.056 13.7 0.7 1.8 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain Elf1 PF05129.8 CCF46593.1 - 0.097 12.3 0.9 0.21 11.3 0.6 1.5 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-C2H2_2 PF12756.2 CCF46593.1 - 0.1 12.7 2.2 0.87 9.7 0.0 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-DNL PF05180.7 CCF46593.1 - 0.4 10.4 3.1 5.1 6.8 0.1 2.4 2 0 0 2 2 2 0 DNL zinc finger zf-AN1 PF01428.11 CCF46593.1 - 0.65 9.9 3.5 4.2 7.3 0.3 2.7 2 0 0 2 2 2 0 AN1-like Zinc finger zf-C2H2_6 PF13912.1 CCF46593.1 - 0.83 9.6 12.1 1.5 8.8 0.3 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.5 CCF46593.1 - 3.2 7.7 4.9 17 5.4 0.1 2.8 2 1 1 3 3 3 0 Zinc ribbon domain DUF3425 PF11905.3 CCF46594.1 - 1e-29 103.1 0.3 1.2e-29 102.9 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) Polyketide_cyc2 PF10604.4 CCF46595.1 - 0.023 14.8 1.3 0.046 13.8 0.9 1.8 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport His_Phos_1 PF00300.17 CCF46596.1 - 1.9e-24 86.5 0.0 2.7e-24 86.0 0.0 1.3 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) SNF2_N PF00176.18 CCF46599.1 - 1.1e-40 139.3 0.0 1.4e-40 138.9 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 CCF46599.1 - 5.6e-06 26.3 0.0 9.4e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PrpF PF04303.8 CCF46601.1 - 1.7e-97 326.5 2.0 2.4e-89 299.6 0.4 2.0 2 0 0 2 2 2 2 PrpF protein ADH_N PF08240.7 CCF46602.1 - 1.6e-25 88.9 6.7 3.1e-25 88.0 4.7 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF46602.1 - 1.1e-22 79.9 0.3 1.6e-21 76.2 0.0 2.9 3 1 0 3 3 3 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 CCF46602.1 - 9.1e-05 21.6 0.2 0.00016 20.9 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.16 CCF46602.1 - 0.00012 21.6 0.0 0.00022 20.8 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ApbA PF02558.11 CCF46602.1 - 0.046 13.1 0.0 0.074 12.4 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AAA_19 PF13245.1 CCF46602.1 - 0.093 12.4 0.5 0.18 11.5 0.3 1.4 1 0 0 1 1 1 0 Part of AAA domain DUF2855 PF11017.3 CCF46603.1 - 5.3e-62 209.7 0.0 6.7e-62 209.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2855) PA_decarbox PF05870.6 CCF46604.1 - 1.4e-09 37.6 0.2 1.9e-09 37.1 0.1 1.1 1 0 0 1 1 1 1 Phenolic acid decarboxylase (PAD) U3_snoRNA_assoc PF08297.6 CCF46606.1 - 7.8e-08 32.4 0.6 7.8e-08 32.4 0.4 4.4 3 2 1 4 4 4 1 U3 snoRNA associated Lyase_aromatic PF00221.14 CCF46608.1 - 9.3e-150 499.1 2.3 1.1e-149 498.9 1.6 1.0 1 0 0 1 1 1 1 Aromatic amino acid lyase DUF4142 PF13628.1 CCF46609.1 - 0.1 12.6 1.1 0.24 11.4 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4142) UQ_con PF00179.21 CCF46610.1 - 2.2e-21 75.7 0.0 3.5e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CCF46610.1 - 0.061 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.17 CCF46610.1 - 0.078 12.8 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 RWD domain NADH_B2 PF14813.1 CCF46611.1 - 0.091 12.4 0.1 0.1 12.2 0.1 1.1 1 0 0 1 1 1 0 NADH dehydrogenase 1 beta subcomplex subunit 2 CMAS PF02353.15 CCF46612.1 - 9.5e-39 133.1 0.8 1.3e-38 132.6 0.6 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.7 CCF46612.1 - 2.3e-17 63.2 0.0 3.9e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF46612.1 - 8.2e-17 61.2 0.0 1.2e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF46612.1 - 2.1e-13 50.3 0.0 3.1e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF46612.1 - 1.2e-11 45.1 0.0 2.6e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF46612.1 - 1.2e-10 41.7 0.0 2e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF46612.1 - 2.1e-08 33.5 0.0 3.1e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 CCF46612.1 - 2.2e-08 34.3 0.0 3.9e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF46612.1 - 2.9e-08 33.2 0.0 5.8e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain DUF938 PF06080.7 CCF46612.1 - 8e-06 25.5 0.0 1.4e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF938) PCMT PF01135.14 CCF46612.1 - 0.0017 17.9 0.4 0.0036 16.8 0.0 1.8 2 1 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.9 CCF46612.1 - 0.0019 17.4 0.0 0.0032 16.6 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_4 PF02390.12 CCF46612.1 - 0.0031 16.6 0.1 0.0074 15.3 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_26 PF13659.1 CCF46612.1 - 0.0048 16.9 0.0 0.0095 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.10 CCF46612.1 - 0.0061 15.7 0.0 0.012 14.7 0.0 1.4 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G HAD PF12710.2 CCF46613.1 - 1.3e-07 32.0 0.1 2.2e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.16 CCF46613.1 - 6.7e-05 22.4 5.0 6.7e-05 22.4 3.5 1.6 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CCF46613.1 - 0.00023 21.6 0.0 0.00038 20.9 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF308 PF03729.8 CCF46613.1 - 0.011 15.6 0.8 0.32 11.0 0.5 2.7 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) Abhydrolase_9_N PF15420.1 CCF46613.1 - 0.025 14.3 1.4 0.025 14.3 0.2 1.6 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus Hydrolase_3 PF08282.7 CCF46613.1 - 0.17 11.4 0.0 0.35 10.4 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase IDO PF01231.13 CCF46615.1 - 3.1e-11 42.3 0.0 4.4e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase PGI PF00342.14 CCF46617.1 - 4.2e-69 233.2 0.0 4.7e-69 233.0 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase CHCH PF06747.8 CCF46618.1 - 1e-05 25.2 3.1 1e-05 25.2 2.2 1.9 2 0 0 2 2 2 1 CHCH domain GCK PF07802.6 CCF46618.1 - 0.046 13.8 1.3 0.083 13.0 0.5 1.6 1 1 1 2 2 2 0 GCK domain Pet191_N PF10203.4 CCF46618.1 - 0.2 11.7 3.8 0.23 11.5 1.6 1.8 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.5 CCF46618.1 - 1.6 8.5 9.0 0.59 9.9 2.7 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Tannase PF07519.6 CCF46619.1 - 3.2e-08 32.7 0.2 3.2e-08 32.7 0.2 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_M35 PF02102.10 CCF46620.1 - 5.1e-67 226.0 14.7 5.7e-67 225.8 10.2 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family adh_short PF00106.20 CCF46621.1 - 1.2e-12 48.0 0.1 2.1e-12 47.2 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF46621.1 - 6.7e-09 35.6 0.1 1.2e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CCF46621.1 - 0.00087 19.1 0.0 0.0013 18.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 CCF46621.1 - 0.064 12.6 0.0 0.099 12.0 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Acetate_kinase PF00871.12 CCF46621.1 - 0.096 11.1 0.0 0.14 10.6 0.0 1.2 1 0 0 1 1 1 0 Acetokinase family Acyl-CoA_dh_1 PF00441.19 CCF46622.1 - 7.8e-41 139.6 1.0 1.5e-40 138.7 0.7 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 CCF46622.1 - 1.2e-30 106.4 0.1 2.4e-30 105.4 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 CCF46622.1 - 4.1e-21 74.2 0.2 8.9e-21 73.1 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 CCF46622.1 - 9.6e-14 51.7 0.1 2e-13 50.7 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.3 CCF46622.1 - 0.00023 20.6 0.4 0.001 18.4 0.3 1.9 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal Carboxyl_trans PF01039.17 CCF46623.1 - 1.2e-143 479.0 0.1 1.6e-143 478.6 0.1 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain NUDIX PF00293.23 CCF46624.1 - 1.2e-10 41.1 0.1 1.2e-09 37.8 0.1 2.0 1 1 0 1 1 1 1 NUDIX domain HTH_psq PF05225.11 CCF46625.1 - 1.6e-13 49.9 0.0 4.1e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF46625.1 - 3.8e-10 39.4 0.1 9e-10 38.2 0.0 1.7 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 CCF46625.1 - 0.00032 19.9 0.0 0.00053 19.1 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.1 CCF46625.1 - 0.0041 16.7 0.1 0.039 13.6 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 CCF46625.1 - 0.015 15.3 0.1 0.098 12.6 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Methyltransf_2 PF00891.13 CCF46626.1 - 9e-20 70.8 0.0 1.2e-19 70.5 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_23 PF13489.1 CCF46626.1 - 0.00026 20.7 0.0 0.0004 20.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF46626.1 - 0.0011 19.5 0.0 0.0018 18.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF46626.1 - 0.063 13.6 0.0 0.17 12.2 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.7 CCF46626.1 - 0.13 12.7 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.11 CCF46628.1 - 3.2e-28 98.4 12.3 3.8e-28 98.2 8.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF46628.1 - 1.9e-07 30.0 5.6 2.7e-07 29.5 3.8 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.1 CCF46628.1 - 9.1e-06 24.3 1.4 9.1e-06 24.3 1.0 2.0 1 1 1 2 2 2 1 MFS/sugar transport protein TRI12 PF06609.8 CCF46628.1 - 0.0026 16.0 1.7 0.0036 15.5 1.2 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Senescence PF06911.7 CCF46630.1 - 4.9e-49 166.4 1.9 7.4e-49 165.8 1.3 1.3 1 0 0 1 1 1 1 Senescence-associated protein Spc97_Spc98 PF04130.8 CCF46631.1 - 9e-71 238.8 0.0 1.1e-70 238.4 0.0 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family Vps51 PF08700.6 CCF46632.1 - 1.8e-30 104.6 0.3 3.6e-30 103.6 0.0 1.6 2 0 0 2 2 2 1 Vps51/Vps67 Dor1 PF04124.7 CCF46632.1 - 0.00033 19.2 0.2 0.00046 18.7 0.1 1.1 1 0 0 1 1 1 1 Dor1-like family COG5 PF10392.4 CCF46632.1 - 0.00048 20.0 0.0 0.00079 19.3 0.0 1.3 1 0 0 1 1 1 1 Golgi transport complex subunit 5 NIF3 PF01784.13 CCF46633.1 - 3.8e-52 177.2 0.0 4.2e-50 170.5 0.0 2.0 1 1 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) BolA PF01722.13 CCF46634.1 - 8.9e-21 73.6 0.0 1.1e-20 73.3 0.0 1.1 1 0 0 1 1 1 1 BolA-like protein Adaptin_N PF01602.15 CCF46635.1 - 2.8e-148 494.5 3.8 4e-148 494.0 2.7 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 CCF46635.1 - 3.8e-26 92.0 0.2 3.2e-25 88.9 0.0 2.3 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 CCF46635.1 - 3.7e-17 62.3 0.4 3.9e-07 30.2 0.0 5.2 3 2 3 6 6 6 3 HEAT repeats HEAT PF02985.17 CCF46635.1 - 1.9e-11 43.0 3.8 0.014 15.4 0.0 5.9 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.1 CCF46635.1 - 1.6e-05 25.2 0.8 2 9.0 0.0 5.7 5 1 1 6 6 6 1 HEAT-like repeat UNC45-central PF11701.3 CCF46635.1 - 0.00015 21.4 0.4 0.6 9.7 0.1 2.9 2 1 0 2 2 2 2 Myosin-binding striated muscle assembly central Arm PF00514.18 CCF46635.1 - 0.0037 17.0 0.5 3.8 7.4 0.0 4.8 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.4 CCF46635.1 - 0.0052 16.4 0.0 0.14 11.8 0.0 3.0 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain CLASP_N PF12348.3 CCF46635.1 - 0.049 12.9 0.3 2 7.6 0.0 3.2 3 1 1 4 4 4 0 CLASP N terminal AF0941-like PF14591.1 CCF46635.1 - 0.26 11.3 3.6 0.46 10.5 1.4 2.2 3 0 0 3 3 3 0 AF0941-like DNA_ligase_A_M PF01068.16 CCF46636.1 - 2.2e-48 164.3 0.3 8.3e-46 155.9 0.0 2.3 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 CCF46636.1 - 3e-40 137.9 0.0 4.7e-40 137.2 0.0 1.3 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 CCF46636.1 - 1e-19 70.7 0.0 2.5e-18 66.2 0.0 3.0 3 0 0 3 3 3 1 ATP dependent DNA ligase C terminal region mRNA_cap_enzyme PF01331.14 CCF46636.1 - 0.063 12.9 0.1 0.3 10.7 0.1 1.9 1 1 0 1 1 1 0 mRNA capping enzyme, catalytic domain FTHFS PF01268.14 CCF46636.1 - 0.22 9.4 0.0 0.33 8.8 0.0 1.1 1 0 0 1 1 1 0 Formate--tetrahydrofolate ligase PCI_Csn8 PF10075.4 CCF46637.1 - 1.1e-35 122.4 0.0 1.6e-35 121.9 0.0 1.2 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 SAC3_GANP PF03399.11 CCF46637.1 - 2.8e-22 79.2 0.2 3.5e-22 78.9 0.1 1.1 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PDCD2_C PF04194.8 CCF46638.1 - 1.8e-50 170.7 0.0 4.4e-50 169.4 0.0 1.6 2 0 0 2 2 2 1 Programmed cell death protein 2, C-terminal putative domain Herpes_capsid PF06112.6 CCF46638.1 - 2.6 8.0 5.3 4.2 7.4 3.7 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Cpn60_TCP1 PF00118.19 CCF46639.1 - 9.6e-149 496.0 0.4 1.1e-148 495.9 0.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Collagen PF01391.13 CCF46640.1 - 1 8.9 17.3 1.3 8.6 10.1 2.4 2 1 0 2 2 2 0 Collagen triple helix repeat (20 copies) AA_permease_2 PF13520.1 CCF46641.1 - 4.2e-34 117.8 31.8 4.7e-34 117.6 22.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF46641.1 - 1e-18 66.9 26.3 1.3e-18 66.6 18.2 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4293 PF14126.1 CCF46641.1 - 3.2 7.6 7.2 1.7 8.5 2.9 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4293) Glyco_hydro_12 PF01670.11 CCF46642.1 - 2.7e-19 69.4 0.1 3e-19 69.3 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 F-box PF00646.28 CCF46643.1 - 1.7e-06 27.5 0.7 3e-06 26.7 0.5 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 CCF46643.1 - 2.9e-06 26.8 1.2 5.8e-06 25.9 0.8 1.4 1 0 0 1 1 1 1 F-box-like SNF2_N PF00176.18 CCF46644.1 - 3.2e-69 233.0 1.8 4e-69 232.6 1.2 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 CCF46644.1 - 4.7e-06 26.2 1.0 8.9e-06 25.2 0.7 1.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 CCF46644.1 - 9.1e-06 25.6 0.0 1.4e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ThuA PF06283.6 CCF46644.1 - 0.032 13.9 0.1 0.093 12.4 0.0 1.7 2 0 0 2 2 2 0 Trehalose utilisation Corona_7 PF02398.11 CCF46645.1 - 0.014 15.8 1.7 0.027 14.9 1.2 1.4 1 0 0 1 1 1 0 Coronavirus protein 7 TgMIC1 PF11476.3 CCF46645.1 - 0.12 11.9 0.1 0.88 9.0 0.0 2.0 2 0 0 2 2 2 0 Toxoplasma gondii micronemal protein 1 TgMIC1 Cep57_CLD_2 PF14197.1 CCF46647.1 - 0.028 14.3 2.7 0.29 11.0 1.9 2.2 1 1 0 1 1 1 0 Centrosome localisation domain of PPC89 DUF1529 PF07485.6 CCF46647.1 - 0.1 12.3 0.1 0.23 11.2 0.0 1.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1259) AMP-binding PF00501.23 CCF46648.1 - 4.7e-149 496.3 0.0 1.5e-76 257.4 0.0 2.6 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.15 CCF46648.1 - 4.6e-95 317.9 0.0 4e-20 71.8 0.0 7.5 5 2 2 7 7 7 7 Condensation domain PP-binding PF00550.20 CCF46648.1 - 1.8e-18 66.5 0.1 3.7e-09 36.7 0.0 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site NAC PF01849.13 CCF46648.1 - 0.4 10.2 0.0 0.82 9.2 0.0 1.5 1 0 0 1 1 1 0 NAC domain Aldedh PF00171.17 CCF46649.1 - 1.2e-38 132.6 0.2 1.3e-38 132.5 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 CCF46649.1 - 0.0046 15.7 0.1 0.0056 15.4 0.1 1.1 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) PHO4 PF01384.15 CCF46652.1 - 2.5e-52 177.5 6.4 2.8e-52 177.3 4.4 1.0 1 0 0 1 1 1 1 Phosphate transporter family CPSase_L_D2 PF02786.12 CCF46653.1 - 4.6e-24 84.8 0.0 6.5e-24 84.3 0.0 1.1 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.1 CCF46653.1 - 3.7e-23 82.2 0.1 9.4e-23 80.8 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 CCF46653.1 - 3.2e-11 42.5 0.0 1.3e-10 40.5 0.0 1.8 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 CCF46653.1 - 1.7e-10 40.4 0.0 3.2e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 CCF46653.1 - 4.8e-09 35.8 0.0 8.4e-09 35.1 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus RimK PF08443.6 CCF46653.1 - 6.3e-06 25.8 0.0 1.2e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GARS_A PF01071.14 CCF46653.1 - 0.0037 16.8 0.0 0.0066 16.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_5 PF13549.1 CCF46653.1 - 0.094 11.9 0.0 0.2 10.8 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain SSP160 PF06933.6 CCF46654.1 - 1.4 6.7 44.9 0.38 8.6 1.5 2.3 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 Pex14_N PF04695.8 CCF46654.1 - 4.7 7.2 13.6 7.8 6.5 9.5 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Macoilin PF09726.4 CCF46654.1 - 6.8 4.8 13.2 7.7 4.6 9.1 1.0 1 0 0 1 1 1 0 Transmembrane protein Apt1 PF10351.4 CCF46654.1 - 6.9 5.4 10.6 8.1 5.1 7.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain CCDC50_N PF15295.1 CCF46655.1 - 0.12 12.3 0.0 0.13 12.1 0.0 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus AhpC-TSA_2 PF13911.1 CCF46656.1 - 1.4e-11 44.3 0.3 5.4e-11 42.4 0.2 1.9 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.16 CCF46656.1 - 1.9e-05 24.3 0.0 3.6e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 CCF46656.1 - 0.00016 21.2 0.0 0.00026 20.5 0.0 1.3 1 0 0 1 1 1 1 Redoxin Thioredoxin_6 PF13848.1 CCF46659.1 - 0.0002 21.1 0.0 0.00031 20.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain NAD_binding_10 PF13460.1 CCF46660.1 - 8.2e-18 65.0 0.0 1e-17 64.7 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF46660.1 - 5.3e-06 25.8 0.0 7.5e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.14 CCF46660.1 - 0.0092 14.7 0.0 0.013 14.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.19 CCF46660.1 - 0.03 14.6 0.0 0.051 13.8 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain TrkA_N PF02254.13 CCF46660.1 - 0.045 13.7 0.0 0.083 12.9 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain ATP-grasp_2 PF08442.5 CCF46662.1 - 1.8e-08 34.0 0.0 4.9e-06 26.0 0.0 2.1 2 0 0 2 2 2 2 ATP-grasp domain FAD_binding_3 PF01494.14 CCF46663.1 - 1e-13 51.0 0.0 1.4e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF46663.1 - 2.2e-09 36.7 0.9 5.3e-06 25.5 0.4 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CCF46663.1 - 1.6e-06 27.2 0.3 3.1e-06 26.3 0.1 1.6 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 CCF46663.1 - 3.1e-06 27.1 0.1 1.1e-05 25.3 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF46663.1 - 5.8e-06 26.3 0.5 9.9e-06 25.5 0.3 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF46663.1 - 7.6e-06 24.6 0.6 0.0019 16.7 0.2 2.0 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox PF00070.22 CCF46663.1 - 2e-05 24.8 0.3 0.0015 18.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF46663.1 - 0.00035 20.7 0.0 0.00055 20.0 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 CCF46663.1 - 0.00082 18.5 0.0 0.001 18.2 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 CCF46663.1 - 0.00097 18.1 0.0 0.0013 17.6 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.17 CCF46663.1 - 0.0019 17.1 0.1 0.0027 16.6 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_Gly3P_dh_N PF01210.18 CCF46663.1 - 0.008 15.9 0.1 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Thi4 PF01946.12 CCF46663.1 - 0.01 14.9 0.0 0.017 14.2 0.0 1.3 1 0 0 1 1 1 1 Thi4 family 3HCDH_N PF02737.13 CCF46663.1 - 0.038 13.6 0.0 0.058 13.0 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Amino_oxidase PF01593.19 CCF46663.1 - 0.053 12.5 0.2 0.097 11.7 0.1 1.5 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase F420_oxidored PF03807.12 CCF46663.1 - 0.059 13.8 0.2 0.1 13.0 0.1 1.3 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_9 PF13454.1 CCF46663.1 - 0.13 12.0 0.2 0.27 10.9 0.1 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding SET PF00856.23 CCF46664.1 - 3.9e-15 56.5 0.0 2.9e-14 53.6 0.0 2.0 1 1 0 1 1 1 1 SET domain SAF PF08666.7 CCF46664.1 - 0.14 12.5 0.0 1.1 9.6 0.0 2.3 2 0 0 2 2 2 0 SAF domain HTH_psq PF05225.11 CCF46665.1 - 1e-11 44.1 0.0 2.2e-11 43.1 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF46665.1 - 2.2e-11 43.3 0.2 1.6e-10 40.5 0.0 2.3 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 CCF46665.1 - 0.0018 17.4 0.0 0.0031 16.6 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.1 CCF46665.1 - 0.0038 16.8 0.1 0.013 15.1 0.0 1.9 2 0 0 2 2 2 1 Homeodomain-like domain HTH_30 PF13556.1 CCF46665.1 - 0.0047 16.4 0.0 0.01 15.3 0.0 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_8 PF02954.14 CCF46665.1 - 0.048 13.1 0.0 0.15 11.6 0.0 1.9 1 1 0 1 1 1 0 Bacterial regulatory protein, Fis family Fungal_trans PF04082.13 CCF46666.1 - 9.2e-15 54.2 0.0 1.9e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain PAF-AH_p_II PF03403.8 CCF46667.1 - 4.1e-49 166.8 0.0 1.5e-23 82.7 0.0 3.1 3 0 0 3 3 3 2 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_5 PF12695.2 CCF46667.1 - 2.8e-15 56.3 0.1 1.8e-06 27.7 0.0 2.3 2 0 0 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF46667.1 - 2.4e-07 30.8 0.0 8.8e-07 29.0 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 CCF46667.1 - 1.9e-06 26.9 0.0 8.4e-05 21.5 0.0 2.2 2 0 0 2 2 2 1 Chlorophyllase enzyme Chlorophyllase PF07224.6 CCF46667.1 - 4.1e-06 25.8 0.0 6.1e-05 21.9 0.0 2.1 2 0 0 2 2 2 1 Chlorophyllase Hydrolase_4 PF12146.3 CCF46667.1 - 0.02 14.7 0.0 0.057 13.2 0.0 1.7 1 0 0 1 1 1 0 Putative lysophospholipase Methyltransf_11 PF08241.7 CCF46670.1 - 1.3e-15 57.6 0.0 2.6e-15 56.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF46670.1 - 5.4e-11 42.3 0.0 8.3e-11 41.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF46670.1 - 4.6e-09 36.5 0.0 8.1e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 CCF46670.1 - 6.2e-09 35.3 0.0 8.2e-09 34.9 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 CCF46670.1 - 1.3e-08 34.7 0.0 2e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF46670.1 - 8.9e-08 32.1 0.1 2.1e-07 30.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF46670.1 - 9.5e-07 29.2 0.0 2.2e-06 28.0 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF46670.1 - 4.1e-06 27.3 0.0 6.5e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF46670.1 - 7.5e-05 22.1 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.13 CCF46670.1 - 0.00018 20.7 0.0 0.00025 20.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.7 CCF46670.1 - 0.00029 20.2 0.0 0.00046 19.6 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW FmrO PF07091.6 CCF46670.1 - 0.00039 19.4 0.0 0.0016 17.5 0.0 1.8 2 0 0 2 2 2 1 Ribosomal RNA methyltransferase (FmrO) TehB PF03848.9 CCF46670.1 - 0.00045 19.4 0.0 0.00091 18.4 0.0 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB PrmA PF06325.8 CCF46670.1 - 0.00093 18.3 0.0 0.0015 17.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.14 CCF46670.1 - 0.0038 16.7 0.0 0.0053 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.13 CCF46670.1 - 0.012 14.8 0.1 0.026 13.6 0.0 1.6 2 0 0 2 2 2 0 O-methyltransferase Methyltransf_32 PF13679.1 CCF46670.1 - 0.012 15.3 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.15 CCF46670.1 - 0.046 12.7 0.0 0.065 12.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_4 PF02390.12 CCF46670.1 - 0.073 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase DOT1 PF08123.8 CCF46670.1 - 0.12 11.7 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 CN_hydrolase PF00795.17 CCF46673.1 - 8e-38 129.6 0.0 1e-37 129.3 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Metallophos PF00149.23 CCF46674.1 - 0.081 12.3 0.2 0.21 10.9 0.1 1.7 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase DAO PF01266.19 CCF46676.1 - 1.6e-10 40.4 0.0 1.7e-10 40.3 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF46676.1 - 3.2e-06 27.0 0.0 3.2e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.13 CCF46676.1 - 4e-05 23.5 0.1 4.5e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 TrkA-N domain Pyr_redox PF00070.22 CCF46676.1 - 7.8e-05 23.0 0.0 7.8e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF46676.1 - 0.00017 21.7 0.1 0.00018 21.6 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF46676.1 - 0.00049 19.0 0.0 0.00053 18.9 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 CCF46676.1 - 0.0005 20.0 0.0 0.00052 19.9 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 CCF46676.1 - 0.00074 18.6 0.0 0.00076 18.6 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.7 CCF46676.1 - 0.00076 18.5 0.1 0.00085 18.3 0.0 1.0 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_9 PF13454.1 CCF46676.1 - 0.003 17.3 0.1 0.0031 17.2 0.0 1.0 1 0 0 1 1 1 1 FAD-NAD(P)-binding Saccharop_dh PF03435.13 CCF46676.1 - 0.0042 16.1 0.1 0.0043 16.0 0.0 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 CCF46676.1 - 0.0096 16.0 0.0 0.011 15.8 0.0 1.1 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ThiF PF00899.16 CCF46676.1 - 0.013 15.2 0.1 0.018 14.8 0.1 1.1 1 0 0 1 1 1 0 ThiF family ApbA PF02558.11 CCF46676.1 - 0.015 14.7 0.0 0.016 14.6 0.0 1.1 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA K_oxygenase PF13434.1 CCF46676.1 - 0.017 14.0 0.0 0.019 13.9 0.0 1.0 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.12 CCF46676.1 - 0.017 14.1 0.0 0.019 14.0 0.0 1.0 1 0 0 1 1 1 0 Thi4 family 3HCDH_N PF02737.13 CCF46676.1 - 0.027 14.1 0.0 0.027 14.1 0.0 1.0 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_10 PF13460.1 CCF46676.1 - 0.048 13.6 0.1 0.048 13.6 0.0 1.0 1 0 0 1 1 1 0 NADH(P)-binding NAD_Gly3P_dh_N PF01210.18 CCF46676.1 - 0.07 12.8 0.0 0.075 12.7 0.0 1.1 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.12 CCF46676.1 - 0.09 13.2 0.0 0.096 13.1 0.0 1.1 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent UDPG_MGDP_dh_N PF03721.9 CCF46676.1 - 0.1 11.9 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.10 CCF46676.1 - 0.11 12.3 0.0 0.12 12.2 0.0 1.1 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase HI0933_like PF03486.9 CCF46676.1 - 0.15 10.4 0.0 0.17 10.3 0.0 1.0 1 0 0 1 1 1 0 HI0933-like protein She2p PF11435.3 CCF46677.1 - 0.037 13.4 0.0 0.039 13.3 0.0 1.1 1 0 0 1 1 1 0 RNA binding protein She2p EB1 PF03271.12 CCF46677.1 - 0.063 13.3 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 EB1-like C-terminal motif Epimerase PF01370.16 CCF46678.1 - 1.3e-23 83.7 0.1 1.5e-23 83.4 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 CCF46678.1 - 2.5e-18 65.9 0.0 3.1e-18 65.6 0.0 1.0 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 CCF46678.1 - 1e-14 53.9 0.0 1.2e-14 53.7 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 CCF46678.1 - 2.3e-10 39.8 0.5 2.2e-09 36.6 0.4 2.0 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.12 CCF46678.1 - 1.1e-08 34.3 0.0 1.7e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.1 CCF46678.1 - 0.0049 16.9 0.0 0.0095 15.9 0.0 1.6 1 1 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 CCF46678.1 - 0.014 15.2 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 short chain dehydrogenase RNA_pol_A_CTD PF03118.10 CCF46678.1 - 0.034 13.5 0.0 0.063 12.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain KR PF08659.5 CCF46678.1 - 0.096 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 KR domain 3HCDH PF00725.17 CCF46680.1 - 6.3e-16 58.5 0.0 9e-16 58.0 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NmrA PF05368.8 CCF46681.1 - 8.8e-38 129.8 0.0 1.1e-37 129.5 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Ribonucleas_3_3 PF14622.1 CCF46682.1 - 4.3e-26 91.3 0.0 6.9e-26 90.6 0.0 1.3 1 1 0 1 1 1 1 Ribonuclease-III-like GcrA PF07750.6 CCF46683.1 - 0.036 14.2 0.0 0.042 14.0 0.0 1.2 1 0 0 1 1 1 0 GcrA cell cycle regulator DUF1466 PF07326.6 CCF46684.1 - 0.026 13.8 0.1 0.031 13.5 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1466) AMP-binding PF00501.23 CCF46685.1 - 3.8e-76 256.1 0.1 5.6e-76 255.5 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.15 CCF46685.1 - 8.1e-55 185.7 0.0 1.2e-54 185.2 0.0 1.3 1 0 0 1 1 1 1 Condensation domain KR PF08659.5 CCF46685.1 - 2.3e-46 157.7 0.2 1e-45 155.6 0.0 2.2 2 0 0 2 2 2 1 KR domain PS-DH PF14765.1 CCF46685.1 - 3.2e-45 154.5 1.2 3.2e-45 154.5 0.8 1.8 2 0 0 2 2 1 1 Polyketide synthase dehydratase adh_short PF00106.20 CCF46685.1 - 5.1e-42 143.6 2.1 3.3e-40 137.7 0.0 3.1 3 0 0 3 3 3 1 short chain dehydrogenase NAD_binding_4 PF07993.7 CCF46685.1 - 5.2e-24 84.5 0.0 2.5e-23 82.3 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein PP-binding PF00550.20 CCF46685.1 - 1.5e-16 60.4 0.2 1.7e-09 37.7 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site Acyl_transf_1 PF00698.16 CCF46685.1 - 1.8e-16 60.3 0.0 3e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Methyltransf_12 PF08242.7 CCF46685.1 - 1.3e-15 57.6 0.0 4e-15 56.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain HxxPF_rpt PF13745.1 CCF46685.1 - 7.6e-11 42.1 0.0 2.4e-10 40.5 0.0 2.0 1 0 0 1 1 1 1 HxxPF-repeated domain Methyltransf_11 PF08241.7 CCF46685.1 - 1.2e-09 38.5 0.0 2.9e-09 37.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF46685.1 - 7.7e-09 35.4 0.0 2.1e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF46685.1 - 3.1e-08 33.3 0.0 8.9e-08 31.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF46685.1 - 6e-08 33.2 0.0 3e-05 24.5 0.0 4.0 4 0 0 4 4 4 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF46685.1 - 1.5e-05 24.1 0.0 3.5e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Epimerase PF01370.16 CCF46685.1 - 3.3e-05 23.4 0.0 0.00058 19.3 0.0 2.6 3 0 0 3 3 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF46685.1 - 5.9e-05 23.1 0.2 0.1 12.6 0.0 3.6 3 0 0 3 3 3 1 NADH(P)-binding 3Beta_HSD PF01073.14 CCF46685.1 - 0.00012 20.9 0.0 0.00041 19.1 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Methyltransf_16 PF10294.4 CCF46685.1 - 0.0096 15.3 0.0 0.027 13.9 0.0 1.7 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_8 PF05148.10 CCF46685.1 - 0.073 12.6 0.0 0.22 11.0 0.0 1.7 2 0 0 2 2 2 0 Hypothetical methyltransferase PhoD PF09423.5 CCF46686.1 - 0.00038 19.1 0.4 0.0061 15.1 0.1 2.0 2 0 0 2 2 2 2 PhoD-like phosphatase FPN1 PF06963.7 CCF46687.1 - 3.2e-108 361.8 5.7 3.7e-108 361.7 3.9 1.0 1 0 0 1 1 1 1 Ferroportin1 (FPN1) Methyltransf_2 PF00891.13 CCF46688.1 - 7.7e-32 110.3 0.0 1e-31 110.0 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_31 PF13847.1 CCF46688.1 - 0.00024 20.7 0.0 0.00036 20.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF46688.1 - 0.002 18.7 0.0 0.0037 17.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 CCF46688.1 - 0.042 13.3 0.0 0.076 12.4 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_12 PF08242.7 CCF46688.1 - 0.058 13.8 0.0 0.16 12.4 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain DUF2407_C PF13373.1 CCF46689.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 DUF2407 C-terminal domain DUF4229 PF14012.1 CCF46690.1 - 0.088 12.7 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4229) Peptidase_M74 PF03411.8 CCF46691.1 - 0.043 13.0 0.0 0.05 12.8 0.0 1.0 1 0 0 1 1 1 0 Penicillin-insensitive murein endopeptidase Cyanate_lyase PF02560.9 CCF46692.1 - 1.4e-32 111.0 0.0 1.9e-32 110.6 0.0 1.2 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_31 PF13560.1 CCF46692.1 - 0.0035 17.5 0.0 0.0053 16.9 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain Lipase_GDSL_2 PF13472.1 CCF46695.1 - 6.4e-22 78.5 0.1 7.7e-22 78.2 0.1 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 CCF46695.1 - 7.8e-11 42.2 0.2 2.3e-10 40.7 0.1 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase ketoacyl-synt PF00109.21 CCF46696.1 - 1.5e-67 227.7 0.0 3.7e-67 226.4 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 CCF46696.1 - 1.7e-46 159.0 0.0 3.1e-46 158.1 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.17 CCF46696.1 - 2.6e-34 117.6 1.7 1.1e-33 115.6 1.0 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.1 CCF46696.1 - 1.2e-21 77.2 0.0 2.3e-21 76.2 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase PP-binding PF00550.20 CCF46696.1 - 2.4e-19 69.3 2.7 7e-11 42.2 0.1 2.6 2 0 0 2 2 2 2 Phosphopantetheine attachment site Thiolase_N PF00108.18 CCF46696.1 - 0.0015 17.5 0.7 0.003 16.5 0.0 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain ketoacyl-synt PF00109.21 CCF46697.1 - 2.6e-58 197.4 0.4 3.7e-58 196.9 0.3 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 CCF46697.1 - 8.1e-39 132.1 0.1 3e-38 130.2 0.1 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.16 CCF46697.1 - 1.1e-09 38.1 0.0 1.7e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Thiolase_N PF00108.18 CCF46697.1 - 8e-08 31.5 0.1 1.4e-07 30.7 0.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Zn_clus PF00172.13 CCF46698.1 - 1.9e-09 37.2 12.8 2.6e-09 36.8 8.9 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Vps39_2 PF10367.4 CCF46698.1 - 0.021 15.0 2.7 0.024 14.7 1.9 1.2 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 DUF3237 PF11578.3 CCF46699.1 - 5.2e-12 45.3 0.0 6.3e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) Ras PF00071.17 CCF46701.1 - 1.8e-51 173.7 0.0 2.2e-51 173.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CCF46701.1 - 1.3e-20 74.0 0.2 4.9e-20 72.1 0.0 1.8 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 CCF46701.1 - 1.3e-11 44.0 0.0 1.6e-11 43.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 CCF46701.1 - 2.9e-06 26.8 0.2 2.9e-05 23.5 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CCF46701.1 - 5.2e-05 23.1 0.0 0.0001 22.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 CCF46701.1 - 0.0014 17.8 0.0 0.0018 17.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.1 CCF46701.1 - 0.0065 16.6 0.2 0.14 12.2 0.1 2.5 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CCF46701.1 - 0.011 15.7 0.1 0.3 11.0 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.17 CCF46701.1 - 0.051 12.4 0.1 0.076 11.8 0.0 1.5 1 1 1 2 2 2 0 NB-ARC domain AAA_33 PF13671.1 CCF46701.1 - 0.051 13.4 0.0 0.13 12.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain Scytalone_dh PF02982.9 CCF46701.1 - 0.056 13.0 0.0 0.15 11.6 0.0 1.6 2 0 0 2 2 2 0 Scytalone dehydratase DUF258 PF03193.11 CCF46701.1 - 0.081 12.1 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 SH3_9 PF14604.1 CCF46705.1 - 2.4e-20 71.8 0.5 1.5e-12 46.8 0.0 2.2 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.23 CCF46705.1 - 2.5e-14 52.3 0.1 4.7e-06 25.8 0.0 2.2 2 0 0 2 2 2 2 SH3 domain SH3_3 PF08239.6 CCF46705.1 - 3.5e-05 23.8 0.3 0.0032 17.6 0.1 2.4 2 0 0 2 2 2 1 Bacterial SH3 domain SH3_2 PF07653.12 CCF46705.1 - 0.0042 16.5 0.0 0.79 9.2 0.0 2.2 2 0 0 2 2 2 2 Variant SH3 domain Elong_Iki1 PF10483.4 CCF46707.1 - 8e-86 287.8 0.0 9.2e-86 287.6 0.0 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 NACHT PF05729.7 CCF46707.1 - 0.22 11.1 1.8 1.4 8.5 1.2 2.0 1 1 0 1 1 1 0 NACHT domain ASXH PF13919.1 CCF46708.1 - 2.3e-26 92.2 0.1 3.6e-26 91.6 0.0 1.3 1 0 0 1 1 1 1 Asx homology domain DUF3433 PF11915.3 CCF46709.1 - 7e-29 99.8 1.9 1.8e-15 56.8 0.7 3.7 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) PP-binding PF00550.20 CCF46710.1 - 4.6e-09 36.4 0.1 5.1e-09 36.2 0.1 1.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site Cu_amine_oxid PF01179.15 CCF46711.1 - 0.15 10.7 0.1 0.17 10.5 0.1 1.1 1 0 0 1 1 1 0 Copper amine oxidase, enzyme domain ProSAAS PF07259.7 CCF46713.1 - 0.036 13.5 0.6 0.044 13.3 0.4 1.2 1 0 0 1 1 1 0 ProSAAS precursor MIP-T3 PF10243.4 CCF46713.1 - 0.58 8.5 16.2 0.69 8.3 11.2 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Ebola_NP PF05505.7 CCF46713.1 - 1.8 6.5 6.9 2 6.3 4.8 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein CDC45 PF02724.9 CCF46713.1 - 8.5 4.2 9.6 9.1 4.1 6.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Pyridox_oxidase PF01243.15 CCF46714.1 - 0.094 12.7 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Polysacc_deac_1 PF01522.16 CCF46715.1 - 4.2e-28 97.4 0.0 6.9e-28 96.7 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.14 CCF46715.1 - 2.3e-06 27.4 14.7 5.1e-06 26.3 10.2 1.5 1 0 0 1 1 1 1 Chitin recognition protein Peroxidase_2 PF01328.12 CCF46716.1 - 2e-44 151.5 0.0 2.6e-44 151.1 0.0 1.0 1 0 0 1 1 1 1 Peroxidase, family 2 GIT_SHD PF08518.6 CCF46718.1 - 3.4e-20 71.0 8.7 2.2e-12 46.0 2.0 2.8 3 0 0 3 3 3 2 Spa2 homology domain (SHD) of GIT DUF1843 PF08898.5 CCF46718.1 - 0.013 15.5 3.7 0.019 14.9 0.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) Glyco_hydro_15 PF00723.16 CCF46720.1 - 1.6e-43 148.9 0.0 4.7e-41 140.8 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 NUDE_C PF04880.8 CCF46722.1 - 8.4e-21 75.0 5.4 8.4e-21 75.0 3.7 5.7 3 2 2 5 5 3 1 NUDE protein, C-terminal conserved region ATG16 PF08614.6 CCF46722.1 - 0.0058 16.4 34.8 0.14 11.9 11.3 3.2 2 1 1 3 3 3 2 Autophagy protein 16 (ATG16) WEMBL PF05701.6 CCF46722.1 - 0.0063 15.0 32.5 0.0091 14.5 22.5 1.2 1 0 0 1 1 1 1 Weak chloroplast movement under blue light DUF904 PF06005.7 CCF46722.1 - 0.012 15.8 10.1 0.012 15.8 7.0 4.1 2 1 1 4 4 4 0 Protein of unknown function (DUF904) Tropomyosin_1 PF12718.2 CCF46722.1 - 0.026 14.3 40.8 0.53 10.1 17.3 3.9 2 1 1 3 3 3 0 Tropomyosin like IncA PF04156.9 CCF46722.1 - 0.13 11.8 41.9 0.074 12.6 13.8 2.6 2 1 1 3 3 3 0 IncA protein Filament PF00038.16 CCF46722.1 - 0.15 11.5 34.3 4.1 6.7 21.8 2.8 2 1 0 2 2 2 0 Intermediate filament protein CENP-F_leu_zip PF10473.4 CCF46722.1 - 0.17 11.7 39.2 0.12 12.2 15.9 4.0 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3584 PF12128.3 CCF46722.1 - 0.23 8.7 26.2 0.37 8.0 18.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Chibby PF14645.1 CCF46722.1 - 0.5 10.2 17.1 3.4 7.5 5.1 2.8 1 1 1 2 2 2 0 Chibby family ERM PF00769.14 CCF46722.1 - 0.7 9.3 32.4 0.11 12.0 6.4 2.3 1 1 1 2 2 2 0 Ezrin/radixin/moesin family ADIP PF11559.3 CCF46722.1 - 1.3 8.9 37.5 0.67 9.8 11.3 3.7 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding FlxA PF14282.1 CCF46722.1 - 6.8 6.6 26.1 14 5.6 8.6 4.0 2 1 2 4 4 4 0 FlxA-like protein Prefoldin_2 PF01920.15 CCF46722.1 - 7.2 6.4 38.2 0.93 9.2 7.2 5.3 2 1 3 5 5 4 0 Prefoldin subunit RTBV_P46 PF06216.6 CCF46722.1 - 8.6 5.0 13.7 1.5 7.6 1.4 2.3 1 1 1 2 2 2 0 Rice tungro bacilliform virus P46 protein PaO PF08417.7 CCF46723.1 - 0.12 12.3 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Pheophorbide a oxygenase Glyco_hyd_65N_2 PF14498.1 CCF46724.1 - 6.2e-59 199.5 0.0 8.3e-59 199.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Sugar_tr PF00083.19 CCF46725.1 - 1.5e-05 23.7 2.5 2.1e-05 23.2 1.7 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter OAF PF14941.1 CCF46726.1 - 0.055 12.6 0.2 0.071 12.2 0.1 1.1 1 0 0 1 1 1 0 Transcriptional regulator, Out at first NPP1 PF05630.6 CCF46728.1 - 6.1e-61 205.7 0.0 7.1e-61 205.5 0.0 1.0 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) HisG PF01634.13 CCF46732.1 - 2.2e-48 163.9 1.5 4.9e-46 156.2 1.1 2.3 1 1 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.6 CCF46732.1 - 1.9e-27 94.9 0.1 4.5e-27 93.7 0.0 1.7 1 0 0 1 1 1 1 HisG, C-terminal domain DUF1805 PF08827.6 CCF46732.1 - 1.8 8.3 6.6 4.9 7.0 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1805) SelR PF01641.13 CCF46733.1 - 2.5e-49 166.0 0.0 3.1e-49 165.7 0.0 1.1 1 0 0 1 1 1 1 SelR domain TF_Zn_Ribbon PF08271.7 CCF46733.1 - 0.13 11.5 1.2 0.9 8.9 0.1 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding DUF2296 PF10058.4 CCF46733.1 - 0.16 11.7 0.4 1.3 8.7 0.0 2.2 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) DZR PF12773.2 CCF46733.1 - 0.31 10.8 3.2 9 6.2 2.2 2.3 1 1 1 2 2 2 0 Double zinc ribbon zf-Mss51 PF13824.1 CCF46733.1 - 0.46 10.3 3.9 7.1 6.5 0.2 3.1 2 1 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Syndecan PF01034.15 CCF46734.1 - 0.73 9.5 2.4 4.1 7.1 0.4 2.5 2 0 0 2 2 2 0 Syndecan domain Pterin_bind PF00809.17 CCF46736.1 - 1.1e-53 181.6 0.0 1.9e-53 180.9 0.0 1.4 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.15 CCF46736.1 - 6.8e-33 113.1 0.0 1.2e-32 112.3 0.0 1.4 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) NMO PF03060.10 CCF46737.1 - 1.1e-70 238.4 0.4 1.4e-70 238.1 0.3 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 CCF46737.1 - 1.1e-07 31.0 0.1 4.1e-07 29.2 0.0 1.8 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 CCF46737.1 - 2.9e-05 23.0 2.1 4.7e-05 22.4 1.5 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.12 CCF46737.1 - 0.0023 16.8 0.1 0.0041 16.0 0.1 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase DHO_dh PF01180.16 CCF46737.1 - 0.0068 15.4 0.1 0.01 14.8 0.1 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase ArfGap PF01412.13 CCF46738.1 - 1.3e-31 108.8 0.1 2.5e-31 107.8 0.1 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf DUF3275 PF11679.3 CCF46738.1 - 0.093 12.3 0.2 0.093 12.3 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3275) HET PF06985.6 CCF46739.1 - 5.5e-22 78.4 2.0 6.4e-21 74.9 1.4 2.2 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) zf-MYND PF01753.13 CCF46740.1 - 1.1e-10 41.2 16.4 2.1e-10 40.2 11.4 1.5 1 0 0 1 1 1 1 MYND finger DUF4470 PF14737.1 CCF46740.1 - 1.7e-09 37.2 0.1 1.8e-07 30.8 0.0 2.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4470) AMP-binding PF00501.23 CCF46742.1 - 1.4e-33 115.8 0.0 7.5e-31 106.9 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.1 CCF46742.1 - 0.052 14.5 0.2 0.47 11.4 0.1 2.3 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain HET PF06985.6 CCF46743.1 - 2.3e-08 34.3 0.1 7.2e-06 26.2 0.1 2.6 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Apolipoprotein PF01442.13 CCF46744.1 - 0.0041 16.6 0.4 0.0051 16.3 0.3 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain CsbD PF05532.7 CCF46744.1 - 0.0078 15.8 22.9 0.27 10.9 9.7 3.3 1 1 1 2 2 2 2 CsbD-like LEA_4 PF02987.11 CCF46744.1 - 0.011 15.5 8.7 0.011 15.5 6.0 2.3 1 1 1 2 2 2 0 Late embryogenesis abundant protein DUF883 PF05957.8 CCF46744.1 - 0.03 14.7 3.8 0.19 12.1 1.8 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) RapA_C PF12137.3 CCF46744.1 - 0.045 12.5 0.0 0.052 12.3 0.0 1.1 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal YtxH PF12732.2 CCF46744.1 - 0.096 13.0 9.7 17 5.8 6.7 2.5 1 1 0 1 1 1 0 YtxH-like protein WXG100 PF06013.7 CCF46744.1 - 0.14 12.1 1.2 0.27 11.2 0.5 1.8 2 0 0 2 2 2 0 Proteins of 100 residues with WXG ATP-synt_B PF00430.13 CCF46744.1 - 1.9 8.3 4.5 2.2 8.0 2.4 1.6 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) ISG65-75 PF11727.3 CCF46744.1 - 2.1 7.3 9.3 5.7 5.9 6.5 1.6 1 1 0 1 1 1 0 Invariant surface glycoprotein Hira PF07569.6 CCF46745.1 - 3e-84 281.6 0.0 4.5e-84 281.0 0.0 1.3 1 0 0 1 1 1 1 TUP1-like enhancer of split Glyco_hydro_7 PF00840.15 CCF46746.1 - 6.3e-57 192.8 0.0 7e-57 192.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 ADH_N PF08240.7 CCF46747.1 - 1.1e-25 89.4 2.1 2.1e-25 88.5 1.5 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_assoc PF13823.1 CCF46747.1 - 7.1e-10 38.3 0.2 1.8e-09 37.0 0.2 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated COQ7 PF03232.8 CCF46748.1 - 7.7e-66 220.8 0.0 9.4e-66 220.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.12 CCF46748.1 - 0.00038 20.7 0.1 0.0007 19.9 0.1 1.6 1 1 0 1 1 1 1 Rubrerythrin Vitellogenin_N PF01347.17 CCF46748.1 - 0.026 12.7 0.0 0.026 12.7 0.0 1.2 1 0 0 1 1 1 0 Lipoprotein amino terminal region Phe_hydrox_dim PF07976.7 CCF46751.1 - 5.6e-47 159.4 0.0 7.3e-47 159.1 0.0 1.1 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Peptidase_C50 PF03568.12 CCF46752.1 - 1.1e-110 369.9 0.0 1.8e-110 369.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family C50 TPR_12 PF13424.1 CCF46752.1 - 1.5e-13 50.4 12.0 4.2e-05 23.4 0.2 4.9 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 CCF46752.1 - 5.4e-05 22.7 3.2 4.8 7.3 0.1 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.1 CCF46752.1 - 0.0055 16.4 0.2 10 6.2 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 CCF46752.1 - 0.0087 15.7 1.6 9.1 6.3 0.1 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat Apc3 PF12895.2 CCF46752.1 - 0.051 13.7 4.6 0.21 11.7 0.0 3.7 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 MFS_1 PF07690.11 CCF46754.1 - 7.3e-11 41.3 0.3 8.5e-11 41.1 0.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily OPT PF03169.10 CCF46757.1 - 9.6e-30 103.5 4.9 1.1e-29 103.3 3.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein 2TM PF13239.1 CCF46757.1 - 0.82 9.7 5.0 4.6 7.3 0.0 2.4 2 0 0 2 2 2 0 2TM domain Clp1 PF06807.9 CCF46758.1 - 3.4e-19 69.3 0.0 4.7e-19 68.9 0.0 1.1 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 ENTH PF01417.15 CCF46759.1 - 5e-51 171.7 0.1 9.7e-51 170.8 0.1 1.5 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.11 CCF46759.1 - 0.0024 16.6 0.0 0.0035 16.0 0.0 1.2 1 0 0 1 1 1 1 ANTH domain UIM PF02809.15 CCF46759.1 - 0.016 14.7 3.5 0.025 14.1 0.3 2.6 2 0 0 2 2 2 0 Ubiquitin interaction motif VHS PF00790.14 CCF46759.1 - 0.026 14.1 0.0 0.049 13.2 0.0 1.4 1 0 0 1 1 1 0 VHS domain DUF4264 PF14084.1 CCF46759.1 - 0.079 12.3 0.1 0.14 11.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4264) SART-1 PF03343.8 CCF46759.1 - 0.08 11.2 10.8 0.12 10.6 7.5 1.2 1 0 0 1 1 1 0 SART-1 family DUF1510 PF07423.6 CCF46759.1 - 0.4 10.0 10.8 1.3 8.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Nucleoporin2 PF04096.9 CCF46760.1 - 1.5e-47 160.9 0.0 2.5e-47 160.2 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nup96 PF12110.3 CCF46760.1 - 5.9e-25 87.9 0.0 8.6e-25 87.4 0.0 1.2 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin_FG PF13634.1 CCF46760.1 - 1.1e-16 61.0 417.8 4.8e-09 36.4 37.5 12.5 1 1 6 8 8 8 5 Nucleoporin FG repeat region Polysacc_deac_1 PF01522.16 CCF46761.1 - 1.2e-25 89.4 0.0 1.8e-25 88.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 CCF46761.1 - 0.0078 15.1 0.0 0.012 14.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 Corona_NS8 PF12093.3 CCF46761.1 - 0.094 13.0 0.0 2.9 8.2 0.0 2.3 2 0 0 2 2 2 0 Coronavirus NS8 protein FAD_binding_4 PF01565.18 CCF46762.1 - 1.5e-28 99.0 0.2 3.7e-28 97.7 0.1 1.6 2 0 0 2 2 2 1 FAD binding domain ALO PF04030.9 CCF46762.1 - 3.4e-21 75.9 0.1 5.1e-21 75.4 0.1 1.3 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase Orthopox_A5L PF06193.6 CCF46764.1 - 0.12 12.2 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Orthopoxvirus A5L protein-like zf-PARP PF00645.13 CCF46767.1 - 9.6e-15 54.6 0.4 1.7e-14 53.8 0.3 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region SKG6 PF08693.5 CCF46770.1 - 0.003 16.8 1.3 0.003 16.8 0.9 1.8 2 0 0 2 2 2 1 Transmembrane alpha-helix domain Rax2 PF12768.2 CCF46770.1 - 0.0077 15.4 0.1 0.016 14.4 0.0 1.3 1 1 0 1 1 1 1 Cortical protein marker for cell polarity Nitrate_red_gam PF02665.9 CCF46770.1 - 0.12 11.7 0.3 0.16 11.3 0.2 1.1 1 0 0 1 1 1 0 Nitrate reductase gamma subunit IBN_N PF03810.14 CCF46771.1 - 5.2e-10 39.1 0.2 1.6e-08 34.2 0.1 2.6 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.7 CCF46771.1 - 9.1e-07 28.8 0.1 2.2e-06 27.6 0.1 1.7 1 1 0 1 1 1 1 Exportin 1-like protein GRIP PF01465.15 CCF46771.1 - 0.0035 16.8 0.1 0.013 15.0 0.1 2.0 1 1 1 2 2 2 1 GRIP domain DUF3530 PF12048.3 CCF46771.1 - 0.0094 14.9 1.0 0.012 14.5 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3530) DUF1907 PF08925.6 CCF46772.1 - 3.3e-62 210.1 0.0 3.8e-62 209.9 0.0 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1907) Aminotran_1_2 PF00155.16 CCF46773.1 - 1.4e-59 201.9 0.0 1.6e-59 201.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Arf PF00025.16 CCF46775.1 - 3e-36 124.2 0.0 3.2e-36 124.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 CCF46775.1 - 7e-14 51.5 0.0 8.4e-14 51.2 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 CCF46775.1 - 6.9e-07 28.2 0.0 9.1e-07 27.8 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Miro PF08477.8 CCF46775.1 - 1.7e-06 28.4 0.0 3e-06 27.7 0.0 1.4 2 0 0 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 CCF46775.1 - 2.6e-05 23.4 0.0 3e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 CCF46775.1 - 0.00043 19.7 0.0 0.00048 19.6 0.0 1.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HTH_32 PF13565.1 CCF46777.1 - 0.049 14.4 1.2 0.074 13.8 0.1 1.7 1 1 1 2 2 2 0 Homeodomain-like domain GRP PF07172.6 CCF46777.1 - 0.26 11.7 4.7 0.3 11.5 3.3 1.2 1 0 0 1 1 1 0 Glycine rich protein family HTH_29 PF13551.1 CCF46777.1 - 0.26 11.4 1.2 0.36 11.0 0.1 1.6 1 1 1 2 2 2 0 Winged helix-turn helix MoCo_carrier PF12694.2 CCF46778.1 - 0.055 12.9 0.1 0.056 12.8 0.1 1.2 1 0 0 1 1 1 0 Putative molybdenum carrier Aldose_epim PF01263.15 CCF46779.1 - 1.7e-55 188.2 0.0 2.2e-55 187.9 0.0 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase DUF3767 PF12597.3 CCF46781.1 - 3e-37 126.8 0.2 7.8e-37 125.5 0.0 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF3767) FlpD PF02662.11 CCF46781.1 - 0.035 13.8 0.3 0.066 12.9 0.2 1.4 1 0 0 1 1 1 0 Methyl-viologen-reducing hydrogenase, delta subunit DNA_pol_B_exo1 PF03104.14 CCF46782.1 - 8.1e-65 218.8 1.6 1.5e-64 217.9 1.1 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.16 CCF46782.1 - 1.3e-21 76.9 0.0 4.6e-21 75.1 0.0 1.8 2 1 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.4 CCF46782.1 - 9.3e-10 38.3 0.1 2.7e-09 36.8 0.1 1.7 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.1 CCF46782.1 - 4.6e-06 26.5 0.6 6.4e-05 22.8 0.0 2.7 2 1 0 2 2 2 1 RNase_H superfamily FA_desaturase PF00487.19 CCF46784.1 - 8.7e-09 35.1 7.5 1.1e-08 34.9 5.2 1.1 1 0 0 1 1 1 1 Fatty acid desaturase zf-CCHC PF00098.18 CCF46785.1 - 0.046 13.6 1.9 0.046 13.6 1.3 1.8 2 0 0 2 2 2 0 Zinc knuckle Trypan_PARP PF05887.6 CCF46785.1 - 0.071 12.9 3.4 0.11 12.3 2.4 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) zf-CCHC_3 PF13917.1 CCF46785.1 - 0.22 11.2 1.4 0.6 9.8 1.0 1.8 1 1 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.1 CCF46785.1 - 0.29 10.6 1.9 0.69 9.4 1.3 1.6 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.1 CCF46785.1 - 1.4 8.6 7.0 0.33 10.6 1.2 2.6 3 0 0 3 3 3 0 Zinc knuckle MFS_1 PF07690.11 CCF46787.1 - 1.6e-21 76.4 32.4 2.1e-21 76.0 22.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily ESSS PF10183.4 CCF46787.1 - 0.014 15.7 0.6 0.035 14.4 0.4 1.6 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) DUF1673 PF07895.6 CCF46787.1 - 0.16 11.4 0.8 0.54 9.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1673) DUF2929 PF11151.3 CCF46787.1 - 0.34 11.0 4.7 0.45 10.6 0.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2929) DUF4131 PF13567.1 CCF46787.1 - 1.8 7.9 9.1 0.24 10.7 1.8 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) GMC_oxred_C PF05199.8 CCF46788.1 - 1.1e-28 100.3 0.0 1.3e-28 100.1 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase PROCN PF08083.6 CCF46790.1 - 4.7e-221 733.4 7.8 7.9e-221 732.7 5.4 1.4 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.3 CCF46790.1 - 3.1e-126 419.3 1.2 6.7e-126 418.2 0.9 1.6 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.4 CCF46790.1 - 1.8e-94 313.4 1.1 4e-94 312.3 0.8 1.6 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.6 CCF46790.1 - 9.4e-75 249.3 4.4 1.6e-74 248.5 2.1 2.2 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.4 CCF46790.1 - 3.6e-67 224.1 0.1 7.6e-67 223.0 0.1 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.4 CCF46790.1 - 7.1e-44 147.5 0.1 2e-43 146.1 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.6 CCF46790.1 - 1.4e-42 144.3 0.9 2.5e-42 143.5 0.1 1.9 2 0 0 2 2 2 1 PROCT (NUC072) domain DUF3753 PF12575.3 CCF46790.1 - 0.082 12.7 0.0 0.24 11.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) MFS_1 PF07690.11 CCF46791.1 - 7.3e-21 74.2 43.2 3.2e-10 39.2 13.4 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.8 CCF46791.1 - 3.9e-13 48.4 10.0 3.9e-13 48.4 6.9 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PUCC PF03209.10 CCF46791.1 - 0.00011 21.0 8.4 0.00011 21.0 5.8 3.4 1 1 1 3 3 3 1 PUCC protein Pox_A14 PF05767.7 CCF46791.1 - 0.0056 16.6 1.1 0.0056 16.6 0.7 3.4 4 1 0 4 4 4 1 Poxvirus virion envelope protein A14 Zn_clus PF00172.13 CCF46793.1 - 1e-07 31.7 6.6 1.3e-07 31.3 4.6 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.7 CCF46793.1 - 4.2 7.6 7.9 2.8 8.1 2.1 2.1 1 1 1 2 2 2 0 Dickkopf N-terminal cysteine-rich region GATase PF00117.23 CCF46794.1 - 1.2e-25 90.1 0.0 1.4e-25 89.8 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.14 CCF46794.1 - 2.2e-08 33.9 0.0 2.4e-06 27.3 0.0 2.0 2 0 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.9 CCF46794.1 - 1.3e-05 24.8 0.1 7.4e-05 22.3 0.0 1.9 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.8 CCF46794.1 - 0.046 13.1 0.1 0.3 10.5 0.1 2.0 1 1 0 1 1 1 0 Peptidase C26 FPN1 PF06963.7 CCF46797.1 - 1.3e-09 37.0 0.0 1.4e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 Ferroportin1 (FPN1) PQ-loop PF04193.9 CCF46798.1 - 2.1e-25 88.0 3.6 4.9e-12 45.2 0.0 2.8 3 0 0 3 3 3 2 PQ loop repeat PIP5K PF01504.13 CCF46800.1 - 1e-85 286.9 0.2 1.5e-85 286.3 0.1 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase COX6B PF02297.12 CCF46801.1 - 2e-23 82.2 5.1 2.7e-23 81.7 3.5 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb IL28A PF15177.1 CCF46801.1 - 0.052 13.0 0.0 0.071 12.6 0.0 1.3 1 0 0 1 1 1 0 Interleukin-28A Pet191_N PF10203.4 CCF46801.1 - 0.092 12.8 0.4 0.15 12.1 0.3 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 SYS1 PF09801.4 CCF46802.1 - 1.9e-45 154.4 0.3 2.1e-45 154.2 0.2 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network TrbE PF11100.3 CCF46802.1 - 0.0081 15.9 0.3 0.016 15.0 0.2 1.5 1 1 0 1 1 1 1 Conjugal transfer protein TrbE DctQ PF04290.7 CCF46802.1 - 1 9.0 13.6 0.41 10.3 3.8 2.1 1 1 1 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component APH PF01636.18 CCF46803.1 - 3.2e-05 23.7 0.6 7.2e-05 22.6 0.1 1.7 1 1 0 2 2 2 1 Phosphotransferase enzyme family AMP-binding PF00501.23 CCF46804.1 - 2.5e-20 72.2 0.0 2.8e-20 72.1 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme DUF4250 PF14056.1 CCF46805.1 - 0.039 13.6 0.1 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) DUF1446 PF07287.6 CCF46806.1 - 7.6e-62 208.8 0.0 9.4e-62 208.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1446) DUF1967 PF09269.6 CCF46808.1 - 0.015 14.9 0.4 7.9 6.2 0.0 2.8 2 1 2 4 4 4 0 Domain of unknown function (DUF1967) PTCB-BRCT PF12738.2 CCF46809.1 - 2e-08 33.9 0.5 4e-08 33.0 0.0 1.7 2 0 0 2 2 2 1 twin BRCT domain BRCT PF00533.21 CCF46809.1 - 3.5e-08 33.4 0.0 8.3e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Ribosomal_S2 PF00318.15 CCF46809.1 - 0.086 12.0 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S2 BATS PF06968.8 CCF46810.1 - 6.6e-31 106.0 0.1 1.9e-30 104.5 0.0 1.8 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.16 CCF46810.1 - 1.5e-16 61.0 0.0 2.4e-16 60.3 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Tubulin PF00091.20 CCF46811.1 - 5.4e-52 176.7 0.0 7.7e-52 176.2 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 CCF46811.1 - 2.9e-44 150.1 0.0 4.5e-44 149.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 CCF46811.1 - 7.2e-05 22.3 0.0 0.00013 21.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Enterotoxin_a PF01375.12 CCF46812.1 - 1.5e-26 93.2 0.0 2.3e-26 92.6 0.0 1.3 1 1 0 1 1 1 1 Heat-labile enterotoxin alpha chain Penaeidin PF05927.6 CCF46813.1 - 4 8.0 11.2 35 5.0 7.8 1.9 1 1 0 1 1 1 0 Penaeidin Pro_CA PF00484.14 CCF46815.1 - 6.2e-12 45.7 0.0 7.4e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 Carbonic anhydrase ThiF PF00899.16 CCF46816.1 - 1.4e-40 138.2 0.0 2.5e-40 137.4 0.0 1.4 1 0 0 1 1 1 1 ThiF family MoeZ_MoeB PF05237.8 CCF46816.1 - 4.5e-22 77.4 0.1 1.1e-21 76.1 0.0 1.7 1 1 0 1 1 1 1 MoeZ/MoeB domain Rhodanese PF00581.15 CCF46816.1 - 3.5e-05 24.1 0.0 6.7e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Shikimate_DH PF01488.15 CCF46816.1 - 0.00053 20.1 0.2 0.015 15.3 0.1 2.5 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 CCF46816.1 - 0.011 16.0 0.0 0.022 14.9 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding MFS_Mycoplasma PF07672.8 CCF46817.1 - 0.0021 17.2 0.4 0.0021 17.2 0.3 2.1 2 0 0 2 2 2 1 Mycoplasma MFS transporter DUF2413 PF10310.4 CCF46821.1 - 7.6e-34 117.2 0.1 8.5e-34 117.1 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2413) DAO PF01266.19 CCF46823.1 - 3.3e-08 32.8 2.9 3.8e-08 32.6 2.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CCF46823.1 - 7e-08 32.3 1.5 8.2e-08 32.1 1.1 1.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CCF46823.1 - 8.6e-06 25.7 1.8 9e-06 25.6 1.3 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF46823.1 - 1.1e-05 25.7 1.8 1.2e-05 25.6 1.3 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF46823.1 - 2.9e-05 23.1 2.5 3e-05 23.0 1.7 1.0 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 CCF46823.1 - 0.00027 19.5 0.7 0.0003 19.3 0.5 1.0 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.2 CCF46823.1 - 0.00033 19.8 2.8 0.00035 19.7 1.9 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_2 PF03446.10 CCF46823.1 - 0.00038 20.3 0.4 0.00042 20.1 0.2 1.1 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase GIDA PF01134.17 CCF46823.1 - 0.0005 19.0 1.6 0.00053 18.9 1.1 1.0 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_Gly3P_dh_N PF01210.18 CCF46823.1 - 0.00074 19.2 0.3 0.00078 19.1 0.2 1.1 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Rossmann-like PF10727.4 CCF46823.1 - 0.0014 18.3 0.1 0.0014 18.3 0.1 1.1 1 0 0 1 1 1 1 Rossmann-like domain FAD_binding_3 PF01494.14 CCF46823.1 - 0.0014 17.7 0.7 0.0015 17.6 0.5 1.0 1 0 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.19 CCF46823.1 - 0.0026 16.9 0.1 0.003 16.6 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase 3HCDH_N PF02737.13 CCF46823.1 - 0.0027 17.3 1.7 0.0028 17.3 1.2 1.0 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GDI PF00996.13 CCF46823.1 - 0.0036 15.6 0.0 0.0039 15.5 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Pyr_redox_3 PF13738.1 CCF46823.1 - 0.0074 16.3 1.8 0.0088 16.1 1.3 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF46823.1 - 0.0087 15.1 0.3 0.0096 15.0 0.2 1.0 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.16 CCF46823.1 - 0.012 15.2 0.4 0.012 15.2 0.3 1.0 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.9 CCF46823.1 - 0.038 12.6 1.0 0.038 12.6 0.7 1.0 1 0 0 1 1 1 0 Tryptophan halogenase Lycopene_cycl PF05834.7 CCF46823.1 - 0.048 12.5 0.2 0.051 12.4 0.2 1.0 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.1 CCF46823.1 - 0.053 13.3 0.6 0.061 13.0 0.4 1.1 1 0 0 1 1 1 0 FAD-NAD(P)-binding TrkA_N PF02254.13 CCF46823.1 - 0.076 13.0 0.3 0.081 12.9 0.2 1.1 1 0 0 1 1 1 0 TrkA-N domain ApbA PF02558.11 CCF46823.1 - 0.088 12.2 1.1 0.1 12.0 0.8 1.1 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.12 CCF46823.1 - 0.1 13.0 0.8 0.11 12.9 0.5 1.1 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 CCF46823.1 - 0.12 11.5 0.5 0.11 11.6 0.4 1.0 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Abhydrolase_5 PF12695.2 CCF46824.1 - 5.8e-08 32.6 0.2 8.2e-08 32.1 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family PAF-AH_p_II PF03403.8 CCF46824.1 - 0.00093 17.5 0.0 0.35 9.1 0.0 2.7 2 1 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II BAAT_C PF08840.6 CCF46824.1 - 0.18 11.4 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal PHO4 PF01384.15 CCF46825.1 - 5.9e-110 366.9 7.1 6.9e-110 366.7 4.9 1.0 1 0 0 1 1 1 1 Phosphate transporter family Chromo PF00385.19 CCF46827.1 - 0.00013 21.5 0.2 0.00032 20.3 0.2 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Ank_2 PF12796.2 CCF46828.1 - 6.6e-12 45.6 0.0 1e-06 28.9 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 CCF46828.1 - 4e-07 29.5 0.0 0.063 13.1 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 CCF46828.1 - 1.6e-05 24.7 0.1 8.3 6.9 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 CCF46828.1 - 0.00015 22.1 0.2 0.036 14.5 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF46828.1 - 0.012 15.8 0.4 15 5.9 0.0 3.4 3 0 0 3 3 3 0 Ankyrin repeats (many copies) AAA_11 PF13086.1 CCF46831.1 - 3.2e-60 203.6 0.2 4.5e-60 203.1 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.1 CCF46831.1 - 1.8e-14 53.5 0.2 1.3e-13 50.8 0.1 2.0 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CCF46831.1 - 6.7e-13 48.1 0.0 1.9e-12 46.7 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 CCF46831.1 - 9.9e-11 41.5 0.0 1.3e-08 34.6 0.0 2.8 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 CCF46831.1 - 1.3e-08 34.8 0.1 1.7e-07 31.2 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.4 CCF46831.1 - 2.6e-07 29.9 1.0 1.4e-06 27.5 0.7 2.2 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 CCF46831.1 - 3.1e-06 27.3 0.0 0.011 15.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain UvrD-helicase PF00580.16 CCF46831.1 - 8e-06 25.3 0.1 0.0008 18.8 0.0 2.0 1 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.13 CCF46831.1 - 1e-05 25.1 0.0 0.018 14.5 0.0 2.3 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.9 CCF46831.1 - 0.00016 21.3 0.0 0.092 12.3 0.0 2.3 2 0 0 2 2 2 2 Helicase DEAD PF00270.24 CCF46831.1 - 0.001 18.6 0.1 0.022 14.2 0.1 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_25 PF13481.1 CCF46831.1 - 0.001 18.5 0.3 0.011 15.1 0.0 2.4 1 1 2 3 3 3 1 AAA domain PhoH PF02562.11 CCF46831.1 - 0.0014 17.8 0.0 0.11 11.6 0.0 2.2 2 0 0 2 2 2 1 PhoH-like protein Zot PF05707.7 CCF46831.1 - 0.0021 17.5 0.1 0.11 11.9 0.0 2.2 1 1 1 2 2 2 1 Zonular occludens toxin (Zot) T2SE PF00437.15 CCF46831.1 - 0.003 16.4 0.0 0.0057 15.5 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.1 CCF46831.1 - 0.0042 17.1 0.3 0.0089 16.0 0.2 1.8 1 1 1 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.12 CCF46831.1 - 0.0044 16.4 0.0 0.014 14.8 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein Flavi_DEAD PF07652.9 CCF46831.1 - 0.0059 16.3 0.0 0.055 13.2 0.0 2.4 3 0 0 3 3 3 1 Flavivirus DEAD domain AAA PF00004.24 CCF46831.1 - 0.008 16.3 0.2 0.054 13.7 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.13 CCF46831.1 - 0.016 14.7 0.1 0.044 13.2 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_10 PF12846.2 CCF46831.1 - 0.024 14.0 0.0 0.44 9.9 0.0 2.1 1 1 1 2 2 2 0 AAA-like domain SKI PF01202.17 CCF46831.1 - 0.028 14.2 0.1 0.079 12.8 0.1 1.8 2 0 0 2 2 2 0 Shikimate kinase AAA_17 PF13207.1 CCF46831.1 - 0.053 14.3 2.6 0.35 11.7 1.4 2.5 2 1 0 2 2 1 0 AAA domain ABC_tran PF00005.22 CCF46831.1 - 0.077 13.3 0.1 0.17 12.1 0.0 1.9 1 1 0 1 1 1 0 ABC transporter 4HB_MCP_1 PF12729.2 CCF46831.1 - 0.079 12.3 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Mg_chelatase PF01078.16 CCF46831.1 - 0.091 11.9 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.10 CCF46831.1 - 0.11 12.1 0.5 7.3 6.2 0.0 2.5 2 0 0 2 2 2 0 NTPase AAA_14 PF13173.1 CCF46831.1 - 0.12 12.2 0.0 2.6 7.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain NUC202 PF08166.7 CCF46832.1 - 0.076 12.8 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 NUC202 domain zf-C2H2_4 PF13894.1 CCF46833.1 - 3.6e-07 30.0 13.2 0.0061 16.8 0.0 4.4 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF46833.1 - 0.00022 21.3 19.1 0.2 12.0 0.0 4.7 4 1 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CCF46833.1 - 0.03 14.6 14.5 0.82 10.0 0.4 4.8 4 1 0 4 4 4 0 Zinc-finger double domain IBR PF01485.16 CCF46833.1 - 0.23 11.3 7.0 17 5.3 3.7 2.8 2 1 0 2 2 2 0 IBR domain DnaJ_CXXCXGXG PF00684.14 CCF46833.1 - 0.54 10.3 3.7 3.5 7.7 0.2 2.4 2 0 0 2 2 2 0 DnaJ central domain CRAL_TRIO PF00650.15 CCF46834.1 - 5.8e-28 97.3 0.0 7.2e-28 97.0 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.1 CCF46834.1 - 8.7e-05 22.4 0.0 0.00011 22.1 0.0 1.1 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Ribosomal_60s PF00428.14 CCF46834.1 - 0.26 11.7 10.7 0.46 10.9 7.4 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein Bacteriocin_IIc PF10439.4 CCF46834.1 - 1.5 8.9 5.4 2.5 8.3 3.8 1.3 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide TRAPP PF04051.11 CCF46835.1 - 5.1e-10 39.0 0.0 6.1e-10 38.8 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component OPT PF03169.10 CCF46837.1 - 6.5e-26 90.9 26.3 3e-25 88.7 18.2 1.8 1 1 0 1 1 1 1 OPT oligopeptide transporter protein ADH_N PF08240.7 CCF46838.1 - 1.1e-22 79.9 2.0 1.6e-22 79.3 1.4 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain MFS_1 PF07690.11 CCF46839.1 - 5.7e-21 74.6 14.2 7.4e-21 74.2 9.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3154 PF11351.3 CCF46839.1 - 0.033 13.9 1.3 0.048 13.4 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3154) Rossmann-like PF10727.4 CCF46839.1 - 0.12 12.1 0.2 0.19 11.4 0.1 1.3 1 0 0 1 1 1 0 Rossmann-like domain TMEM107 PF14995.1 CCF46839.1 - 0.37 10.9 3.0 1.1 9.3 0.1 2.5 2 1 1 3 3 3 0 Transmembrane protein Pex24p PF06398.6 CCF46840.1 - 3.2e-41 141.3 0.3 4.7e-41 140.7 0.2 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Reticulon PF02453.12 CCF46840.1 - 0.0082 15.7 0.2 0.021 14.4 0.1 1.7 2 1 0 2 2 2 1 Reticulon DUF3292 PF11696.3 CCF46840.1 - 0.011 13.7 0.1 0.015 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF639 PF04842.7 CCF46840.1 - 0.077 11.1 0.1 0.11 10.6 0.1 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) AAA_2 PF07724.9 CCF46841.1 - 3.6e-44 150.6 0.0 5.3e-44 150.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.4 CCF46841.1 - 1e-10 41.3 2.1 4.1e-07 29.8 0.0 2.6 1 1 1 2 2 2 2 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 CCF46841.1 - 1e-09 38.2 0.0 1.7e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.24 CCF46841.1 - 4.4e-07 30.1 0.0 9.6e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 CCF46841.1 - 5.2e-05 22.7 0.0 8.2e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_16 PF13191.1 CCF46841.1 - 0.00045 20.2 0.9 0.023 14.6 0.0 2.6 2 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 CCF46841.1 - 0.0017 18.4 0.1 0.0091 16.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CCF46841.1 - 0.0018 19.0 0.2 0.0038 18.0 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_10 PF12846.2 CCF46841.1 - 0.0043 16.5 0.0 0.069 12.5 0.0 2.1 1 1 0 1 1 1 1 AAA-like domain AAA_14 PF13173.1 CCF46841.1 - 0.014 15.2 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CCF46841.1 - 0.019 15.2 0.1 0.047 13.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 CCF46841.1 - 0.035 14.3 0.0 0.053 13.8 0.0 1.3 1 0 0 1 1 1 0 ABC transporter MobB PF03205.9 CCF46841.1 - 0.039 13.6 0.0 0.078 12.6 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 CCF46841.1 - 0.049 13.8 0.1 0.22 11.6 0.0 2.2 2 1 0 2 2 2 0 RNA helicase Mg_chelatase PF01078.16 CCF46841.1 - 0.058 12.5 0.0 0.45 9.6 0.0 2.2 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI NACHT PF05729.7 CCF46841.1 - 0.074 12.7 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 NACHT domain SRP54 PF00448.17 CCF46841.1 - 0.082 12.3 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.7 CCF46841.1 - 0.12 11.4 0.0 0.25 10.4 0.0 1.5 1 1 0 1 1 1 0 Zeta toxin PduV-EutP PF10662.4 CCF46841.1 - 0.16 11.4 0.0 0.3 10.5 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Arf PF00025.16 CCF46842.1 - 2.5e-80 267.8 0.3 2.8e-80 267.6 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 CCF46842.1 - 1.6e-14 53.5 0.0 2e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 CCF46842.1 - 2.4e-13 49.8 0.0 2.6e-13 49.6 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 CCF46842.1 - 2.2e-12 46.3 2.0 2.5e-09 36.3 0.5 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 CCF46842.1 - 3.5e-11 42.6 0.0 4.3e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 CCF46842.1 - 1.2e-08 35.4 0.0 1.8e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 CCF46842.1 - 2.5e-06 27.4 0.0 3.3e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.13 CCF46842.1 - 0.009 15.1 0.7 0.02 13.9 0.5 1.7 1 1 0 1 1 1 1 6-phosphofructo-2-kinase GTP_EFTU PF00009.22 CCF46842.1 - 0.012 15.0 0.2 0.093 12.1 0.0 1.9 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_33 PF13671.1 CCF46842.1 - 0.04 13.7 0.2 0.097 12.5 0.1 1.9 1 1 0 1 1 1 0 AAA domain EMP24_GP25L PF01105.19 CCF46843.1 - 8.3e-44 149.4 0.0 9.7e-44 149.2 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Dioxygenase_C PF00775.16 CCF46843.1 - 0.0061 15.8 0.0 0.0088 15.3 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase DUF3405 PF11885.3 CCF46844.1 - 8.2e-212 703.8 3.9 1e-211 703.4 2.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) DUF3659 PF12396.3 CCF46845.1 - 1.4e-16 59.9 3.8 1.4e-16 59.9 2.7 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3659) RRM_1 PF00076.17 CCF46847.1 - 1.1e-08 34.5 0.1 1.9e-08 33.7 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF46847.1 - 7.5e-08 32.2 0.0 1.3e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CCF46847.1 - 0.00032 20.4 0.0 0.00057 19.5 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.1 CCF46847.1 - 0.011 15.5 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MFS_1 PF07690.11 CCF46848.1 - 1.2e-35 122.9 21.3 1.6e-35 122.4 14.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans PF04082.13 CCF46849.1 - 1.4e-23 83.0 0.0 2.5e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF46849.1 - 1.4e-07 31.3 12.1 2.3e-07 30.5 8.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hydantoinase_B PF02538.9 CCF46851.1 - 2.3e-185 616.8 0.0 3.2e-185 616.3 0.0 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.13 CCF46851.1 - 5e-95 317.9 1.1 6.6e-95 317.5 0.0 1.7 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 CCF46851.1 - 4e-56 189.2 3.8 1.3e-55 187.6 0.1 2.4 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region Arginase PF00491.16 CCF46854.1 - 1.4e-88 296.7 0.0 1.8e-88 296.4 0.0 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.2 CCF46854.1 - 0.11 12.7 0.1 0.24 11.6 0.0 1.6 1 1 0 1 1 1 0 UPF0489 domain DUF1589 PF07628.6 CCF46854.1 - 0.12 12.2 0.0 0.63 9.9 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1589) DUF1816 PF08846.5 CCF46855.1 - 0.19 11.4 0.8 0.33 10.6 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1816) 2-ph_phosp PF04029.9 CCF46856.1 - 0.041 12.8 0.0 0.081 11.8 0.0 1.3 1 0 0 1 1 1 0 2-phosphosulpholactate phosphatase SpoU_methylase PF00588.14 CCF46857.1 - 7.4e-28 97.2 0.0 1.2e-27 96.5 0.0 1.3 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.7 CCF46857.1 - 1e-09 38.3 0.0 2.2e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding MIP-T3 PF10243.4 CCF46857.1 - 8.7 4.6 19.1 14 3.9 13.2 1.4 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 zf-PHD-like PF15446.1 CCF46859.1 - 1.7e-71 239.1 9.9 4.2e-71 237.8 6.9 1.7 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain SNF2_N PF00176.18 CCF46859.1 - 2e-58 197.5 0.1 3.6e-58 196.7 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CCF46859.1 - 1.7e-14 53.4 0.0 7.9e-14 51.2 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Chromo PF00385.19 CCF46859.1 - 5e-08 32.4 0.7 1.9e-05 24.2 0.3 3.5 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain DEAD PF00270.24 CCF46859.1 - 2.3e-06 27.2 0.0 4.2e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase PHD PF00628.24 CCF46859.1 - 7.9e-05 22.2 4.4 7.9e-05 22.2 3.0 3.2 2 1 1 3 3 3 1 PHD-finger PHD_2 PF13831.1 CCF46859.1 - 0.016 14.4 0.4 0.016 14.4 0.3 2.8 3 0 0 3 3 3 0 PHD-finger DUF4434 PF14488.1 CCF46860.1 - 0.033 13.9 0.1 0.051 13.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) Amidohydro_2 PF04909.9 CCF46861.1 - 9.7e-07 28.6 0.0 1.2e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_4 PF13147.1 CCF46861.1 - 1.2e-06 28.8 0.9 1.6e-06 28.3 0.7 1.2 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 CCF46861.1 - 5.6e-06 26.2 0.9 1.1e-05 25.2 0.6 1.7 1 1 0 1 1 1 1 Amidohydrolase family TatD_DNase PF01026.16 CCF46861.1 - 0.0064 15.7 0.2 0.013 14.6 0.1 1.6 1 1 0 1 1 1 1 TatD related DNase dTMP_synthase PF02593.9 CCF46861.1 - 0.014 14.7 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 Thymidylate synthase LysR_substrate PF03466.15 CCF46861.1 - 0.027 13.5 0.0 0.15 11.1 0.0 2.0 2 0 0 2 2 2 0 LysR substrate binding domain CoA_binding_2 PF13380.1 CCF46861.1 - 0.064 13.4 0.0 0.28 11.3 0.0 2.1 2 0 0 2 2 2 0 CoA binding domain Autoind_synth PF00765.12 CCF46862.1 - 0.063 12.5 0.0 0.14 11.3 0.0 1.7 1 0 0 1 1 1 0 Autoinducer synthetase YL1_C PF08265.6 CCF46862.1 - 0.11 12.0 1.0 0.24 11.0 0.2 1.9 2 0 0 2 2 2 0 YL1 nuclear protein C-terminal domain DUF1515 PF07439.6 CCF46862.1 - 0.16 11.8 0.3 14 5.5 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) ADH_N PF08240.7 CCF46863.1 - 0.0052 16.5 0.0 0.0073 16.0 0.0 1.2 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain HMG_CoA_synt_N PF01154.12 CCF46865.1 - 6.3e-95 315.6 0.4 8.9e-95 315.1 0.3 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.5 CCF46865.1 - 1.4e-72 244.5 0.6 2.1e-72 244.0 0.4 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal Aminotran_5 PF00266.14 CCF46866.1 - 1.4e-74 251.1 0.0 1.8e-74 250.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 CCF46866.1 - 2.1e-07 30.3 0.1 3.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 CCF46866.1 - 2e-05 23.8 0.0 3.1e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.14 CCF46866.1 - 0.0014 17.1 0.0 0.0024 16.4 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.15 CCF46866.1 - 0.0058 14.9 0.0 0.0081 14.4 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme B12-binding PF02310.14 CCF46866.1 - 0.028 14.2 0.0 0.63 9.9 0.0 2.4 2 1 0 2 2 2 0 B12 binding domain SIS_2 PF13580.1 CCF46866.1 - 0.035 13.8 0.0 0.085 12.5 0.0 1.7 2 0 0 2 2 2 0 SIS domain Tcell_CD4_Cterm PF12104.3 CCF46866.1 - 0.059 12.9 1.9 0.31 10.6 0.1 2.3 2 0 0 2 2 2 0 T cell CD4 receptor C terminal region RbsD_FucU PF05025.8 CCF46867.1 - 5e-38 130.6 0.0 5.6e-38 130.4 0.0 1.0 1 0 0 1 1 1 1 RbsD / FucU transport protein family DASH_Spc34 PF08657.5 CCF46869.1 - 4.2e-37 128.2 0.0 7.2e-36 124.1 0.0 2.0 1 1 0 1 1 1 1 DASH complex subunit Spc34 ABC2_membrane PF01061.19 CCF46870.1 - 7.1e-46 156.0 16.6 9.8e-46 155.5 11.5 1.1 1 0 0 1 1 1 1 ABC-2 type transporter ABC_trans_N PF14510.1 CCF46870.1 - 2.2e-20 72.5 0.0 5.6e-20 71.2 0.0 1.8 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal ABC_tran PF00005.22 CCF46870.1 - 3.7e-18 66.1 0.0 6.4e-15 55.6 0.0 2.3 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.2 CCF46870.1 - 0.0056 15.7 12.4 0.0056 15.7 8.6 1.5 1 1 0 1 1 1 1 ABC-2 family transporter protein CDP-OH_P_transf PF01066.16 CCF46871.1 - 3e-13 49.9 5.0 3e-13 49.9 3.5 2.7 3 1 0 3 3 3 1 CDP-alcohol phosphatidyltransferase Aldedh PF00171.17 CCF46873.1 - 2.9e-36 124.8 0.1 3.2e-36 124.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family ABC2_membrane PF01061.19 CCF46874.1 - 2.1e-42 144.7 22.3 2.1e-42 144.7 15.5 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 CCF46874.1 - 5.2e-13 48.7 7.1 8.6e-13 48.0 4.9 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein PDR_CDR PF06422.7 CCF46874.1 - 0.0089 15.6 0.3 0.0089 15.6 0.2 2.9 2 1 0 2 2 2 1 CDR ABC transporter Nup96 PF12110.3 CCF46875.1 - 2.3e-71 240.2 0.6 3e-71 239.9 0.4 1.1 1 0 0 1 1 1 1 Nuclear protein 96 Sec39 PF08314.6 CCF46877.1 - 7.5e-194 645.6 0.0 1.1e-133 446.7 0.0 2.0 1 1 1 2 2 2 2 Secretory pathway protein Sec39 Ndufs5 PF10200.4 CCF46878.1 - 8.8e-06 25.6 0.0 9.6e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DUF3128 PF11326.3 CCF46878.1 - 0.017 15.2 0.6 0.031 14.3 0.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) COX6B PF02297.12 CCF46878.1 - 0.058 13.4 0.3 0.084 12.8 0.2 1.3 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb ROKNT PF08067.6 CCF46879.1 - 0.11 12.3 0.1 0.24 11.2 0.1 1.5 1 0 0 1 1 1 0 ROKNT (NUC014) domain Antitoxin-MazE PF04014.13 CCF46880.1 - 0.00051 19.7 0.1 1.3 8.8 0.0 2.4 2 0 0 2 2 2 2 Antidote-toxin recognition MazE NAD_binding_1 PF00175.16 CCF46880.1 - 0.0066 17.0 0.0 0.012 16.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 CCF46880.1 - 0.033 14.0 0.0 0.051 13.4 0.0 1.3 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Band_7_1 PF13421.1 CCF46880.1 - 0.046 13.2 0.0 2 7.8 0.0 2.1 2 0 0 2 2 2 0 SPFH domain-Band 7 family Adaptin_N PF01602.15 CCF46881.1 - 4.1e-30 104.5 0.7 4.9e-30 104.3 0.5 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 CCF46881.1 - 3.6e-18 65.9 0.0 1.1e-17 64.3 0.0 1.9 1 0 0 1 1 1 1 Adaptin C-terminal domain G-patch_2 PF12656.2 CCF46881.1 - 0.064 13.1 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 DExH-box splicing factor binding site Spt20 PF12090.3 CCF46881.1 - 0.25 10.6 1.9 2.4 7.4 0.0 2.2 2 0 0 2 2 2 0 Spt20 family Condensation PF00668.15 CCF46882.1 - 0.022 13.6 0.0 0.09 11.6 0.0 1.9 1 1 0 1 1 1 0 Condensation domain DnaB_bind PF10410.4 CCF46884.1 - 0.043 13.8 0.0 0.056 13.4 0.0 1.1 1 0 0 1 1 1 0 DnaB-helicase binding domain of primase DS PF01916.12 CCF46885.1 - 9.1e-57 192.4 0.1 1e-56 192.2 0.1 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase CmcH_NodU PF02543.10 CCF46885.1 - 0.05 12.7 0.1 0.055 12.5 0.0 1.0 1 0 0 1 1 1 0 Carbamoyltransferase MARVEL PF01284.18 CCF46886.1 - 4.8e-09 36.1 7.9 6e-09 35.8 5.5 1.0 1 0 0 1 1 1 1 Membrane-associating domain DUF2374 PF09574.5 CCF46886.1 - 0.11 12.1 0.7 0.2 11.2 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (Duf2374) Steroid_dh PF02544.11 CCF46887.1 - 1.7e-18 66.8 1.5 7.6e-13 48.4 1.0 2.2 2 0 0 2 2 2 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.7 CCF46887.1 - 0.032 13.5 4.9 0.097 11.9 3.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1295) Aldedh PF00171.17 CCF46888.1 - 1.2e-154 515.0 0.1 1.4e-154 514.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family BLVR PF06375.6 CCF46889.1 - 0.012 15.4 1.8 0.013 15.3 1.2 1.1 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) Thioredoxin_4 PF13462.1 CCF46889.1 - 0.093 12.7 1.0 0.11 12.5 0.7 1.1 1 0 0 1 1 1 0 Thioredoxin TT_ORF2 PF02957.10 CCF46889.1 - 0.12 13.0 1.2 0.13 12.9 0.8 1.0 1 0 0 1 1 1 0 TT viral ORF2 ATP-synt_E PF05680.7 CCF46889.1 - 1.2 9.0 6.5 1.4 8.9 4.5 1.2 1 0 0 1 1 1 0 ATP synthase E chain RRM_1 PF00076.17 CCF46890.1 - 4.1e-17 61.5 0.1 5.3e-17 61.2 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF46890.1 - 1.3e-13 50.6 0.1 1.7e-13 50.2 0.1 1.1 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF46890.1 - 7.2e-08 32.1 0.0 1.1e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-MIZ PF02891.15 CCF46891.1 - 5.7e-08 32.1 4.6 2.9e-06 26.6 0.3 2.7 2 0 0 2 2 2 2 MIZ/SP-RING zinc finger Hom_end_hint PF05203.11 CCF46891.1 - 2.5e-05 24.0 0.8 3.6e-05 23.6 0.6 1.3 1 0 0 1 1 1 1 Hom_end-associated Hint Mem_trans PF03547.13 CCF46891.1 - 0.026 12.8 0.3 0.031 12.5 0.2 1.2 1 0 0 1 1 1 0 Membrane transport protein Rrn6 PF10214.4 CCF46891.1 - 0.45 8.5 29.2 0.97 7.4 20.2 1.6 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Neur_chan_memb PF02932.11 CCF46891.1 - 2.1 8.1 18.9 6.1 6.6 13.1 1.9 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Cellulose_synt PF03552.9 CCF46891.1 - 6.4 4.9 9.5 9.8 4.3 6.6 1.1 1 0 0 1 1 1 0 Cellulose synthase Herpes_UL87 PF03043.9 CCF46891.1 - 7.1 4.8 15.2 11 4.2 10.5 1.2 1 0 0 1 1 1 0 Herpesvirus UL87 family Hid1 PF12722.2 CCF46891.1 - 7.2 4.1 32.1 11 3.5 22.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Arrestin_N PF00339.24 CCF46893.1 - 4e-14 52.6 0.1 1.6e-08 34.4 0.0 3.1 2 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 CCF46893.1 - 0.15 12.2 0.0 8.8 6.4 0.0 2.4 2 0 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain SET PF00856.23 CCF46894.1 - 3.5e-07 30.6 0.0 1.9e-06 28.3 0.0 2.1 1 1 0 1 1 1 1 SET domain MFS_1 PF07690.11 CCF46896.1 - 3.3e-11 42.5 21.0 4.4e-11 42.1 14.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF46896.1 - 8.2e-08 31.2 6.4 1.1e-07 30.8 4.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter HET PF06985.6 CCF46898.1 - 5.8e-05 23.2 0.0 0.083 13.0 0.0 2.9 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) Maf_N PF08383.6 CCF46898.1 - 0.092 12.3 0.5 0.27 10.8 0.1 1.9 2 0 0 2 2 2 0 Maf N-terminal region Aft1_HRR PF11787.3 CCF46899.1 - 6.3 7.9 15.0 0.32 12.0 5.9 2.1 2 1 0 2 2 2 0 Aft1 HRR domain AA_kinase PF00696.23 CCF46901.1 - 2e-24 86.4 0.0 3.5e-24 85.6 0.0 1.4 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.20 CCF46901.1 - 5.4e-15 54.5 1.4 1.6e-09 36.9 0.1 2.4 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.1 CCF46901.1 - 1.8e-14 53.0 4.0 7.8e-10 38.1 0.1 2.4 2 0 0 2 2 2 2 ACT domain Peptidase_C14 PF00656.17 CCF46902.1 - 0.00015 21.5 0.0 0.00019 21.2 0.0 1.2 1 0 0 1 1 1 1 Caspase domain Epimerase PF01370.16 CCF46904.1 - 1.8e-05 24.2 0.0 0.0088 15.4 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.19 CCF46904.1 - 9.7e-05 22.6 0.0 0.00037 20.7 0.0 1.9 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.14 CCF46904.1 - 0.00033 19.4 0.0 0.0025 16.5 0.0 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 CCF46904.1 - 0.003 16.5 0.0 0.018 13.9 0.0 2.2 2 1 0 3 3 3 1 Male sterility protein NAD_binding_10 PF13460.1 CCF46904.1 - 0.0048 16.9 0.0 0.01 15.8 0.0 1.5 1 1 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CCF46904.1 - 0.0072 15.6 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Shikimate_DH PF01488.15 CCF46904.1 - 0.12 12.4 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Cep57_CLD_2 PF14197.1 CCF46905.1 - 5.6e-28 96.6 62.3 1.1e-15 57.3 4.4 5.8 4 1 1 5 5 5 2 Centrosome localisation domain of PPC89 Cep57_MT_bd PF06657.8 CCF46905.1 - 3.5e-23 81.3 0.5 3.5e-23 81.3 0.3 6.1 5 2 0 5 5 5 1 Centrosome microtubule-binding domain of Cep57 ATG16 PF08614.6 CCF46905.1 - 0.0011 18.8 29.4 0.0011 18.8 20.4 5.4 3 2 2 5 5 5 1 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.2 CCF46905.1 - 0.0028 17.5 1.4 0.0028 17.5 1.0 5.9 2 1 3 5 5 5 1 Tropomyosin like CCDC155 PF14662.1 CCF46905.1 - 0.027 14.0 0.6 0.027 14.0 0.4 5.0 2 1 3 5 5 5 0 Coiled-coil region of CCDC155 DUF730 PF05325.6 CCF46905.1 - 0.034 13.9 0.5 0.034 13.9 0.4 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF730) HALZ PF02183.13 CCF46905.1 - 0.12 12.0 47.4 0.25 11.0 2.2 8.7 5 1 4 9 9 9 0 Homeobox associated leucine zipper WEMBL PF05701.6 CCF46905.1 - 0.32 9.3 48.4 0.12 10.7 28.4 3.1 2 1 1 3 3 3 0 Weak chloroplast movement under blue light ABC2_membrane PF01061.19 CCF46906.1 - 9.4e-35 119.6 13.3 1.3e-34 119.2 9.2 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 CCF46906.1 - 6.9e-06 25.3 5.9 6.9e-06 25.3 4.1 1.8 1 1 1 2 2 2 1 ABC-2 family transporter protein PDR_CDR PF06422.7 CCF46906.1 - 0.024 14.3 0.1 0.086 12.5 0.0 1.9 1 0 0 1 1 1 0 CDR ABC transporter CBM_48 PF02922.13 CCF46907.1 - 0.017 15.1 0.2 0.024 14.6 0.1 1.3 1 0 0 1 1 1 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) CBM_25 PF03423.8 CCF46907.1 - 0.067 13.2 0.1 0.12 12.4 0.1 1.5 1 1 0 1 1 1 0 Carbohydrate binding domain (family 25) Tektin PF03148.9 CCF46908.1 - 0.1 11.1 2.1 0.14 10.6 1.5 1.1 1 0 0 1 1 1 0 Tektin family DUF3450 PF11932.3 CCF46908.1 - 2.5 7.2 8.9 5.4 6.1 6.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Abhydrolase_6 PF12697.2 CCF46909.1 - 8.8e-26 91.1 0.2 1.6e-25 90.3 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF46909.1 - 5.1e-17 61.9 0.0 1.5e-16 60.4 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF46909.1 - 6e-11 42.3 0.0 9.7e-10 38.3 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.8 CCF46909.1 - 3.3e-07 30.1 0.1 2.5e-06 27.2 0.1 2.0 1 1 0 1 1 1 1 PGAP1-like protein Thioesterase PF00975.15 CCF46909.1 - 4.1e-05 23.9 0.0 8.7e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain DUF3089 PF11288.3 CCF46909.1 - 0.00068 18.8 0.0 0.0014 17.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3089) Thiolase_C PF02803.13 CCF46909.1 - 0.0018 17.7 0.0 3.1 7.2 0.0 2.8 3 0 0 3 3 3 2 Thiolase, C-terminal domain DUF900 PF05990.7 CCF46909.1 - 0.0047 16.2 0.0 0.0076 15.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Hydrolase_4 PF12146.3 CCF46909.1 - 0.011 15.5 0.0 0.025 14.4 0.0 1.6 1 0 0 1 1 1 0 Putative lysophospholipase Abhydrolase_2 PF02230.11 CCF46909.1 - 0.012 15.0 0.0 0.89 8.9 0.0 2.5 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase VirJ PF06057.6 CCF46909.1 - 0.017 14.9 0.0 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) DUF2305 PF10230.4 CCF46909.1 - 0.03 13.7 0.0 0.051 12.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) DUF676 PF05057.9 CCF46909.1 - 0.048 12.9 0.0 0.074 12.3 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) LCAT PF02450.10 CCF46909.1 - 0.053 12.4 0.0 0.089 11.7 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Lipase_3 PF01764.20 CCF46909.1 - 0.075 12.6 0.0 0.19 11.3 0.0 1.5 1 1 0 1 1 1 0 Lipase (class 3) DUF498 PF04430.9 CCF46910.1 - 1.8e-27 95.0 0.0 2.4e-27 94.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Ribosomal_L34e PF01199.13 CCF46911.1 - 1.9e-37 127.3 2.7 2.7e-37 126.8 1.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L34e DUF4222 PF13973.1 CCF46911.1 - 0.095 12.1 0.1 0.15 11.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4222) FhuF_C PF11575.3 CCF46911.1 - 0.39 10.4 5.6 2.5 7.8 0.2 3.0 3 0 0 3 3 3 0 FhuF 2Fe-2S C-terminal domain Zn_ribbon_recom PF13408.1 CCF46911.1 - 0.55 10.5 2.9 0.34 11.1 0.2 2.0 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain FAR1 PF03101.10 CCF46913.1 - 3.2e-05 24.3 0.1 5.5e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 FAR1 DNA-binding domain Tektin PF03148.9 CCF46913.1 - 0.0056 15.2 0.2 0.0073 14.8 0.1 1.1 1 0 0 1 1 1 1 Tektin family AFT PF08731.6 CCF46913.1 - 0.0094 16.1 0.1 0.014 15.5 0.1 1.3 1 0 0 1 1 1 1 Transcription factor AFT Tropomyosin_1 PF12718.2 CCF46913.1 - 0.028 14.2 0.0 0.044 13.6 0.0 1.2 1 0 0 1 1 1 0 Tropomyosin like XhlA PF10779.4 CCF46913.1 - 0.055 13.3 0.0 0.09 12.6 0.0 1.4 1 0 0 1 1 1 0 Haemolysin XhlA Hemagglutinin PF00509.13 CCF46913.1 - 0.066 11.3 0.0 0.085 10.9 0.0 1.1 1 0 0 1 1 1 0 Haemagglutinin Vac_Fusion PF02346.11 CCF46913.1 - 0.15 11.4 0.2 0.77 9.2 0.2 2.2 1 1 1 2 2 2 0 Chordopoxvirus fusion protein DUF1604 PF07713.8 CCF46915.1 - 0.00043 20.0 1.0 0.0008 19.1 0.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1604) Ecm33 PF12454.3 CCF46916.1 - 0.13 12.1 0.1 0.22 11.4 0.0 1.4 2 0 0 2 2 2 0 GPI-anchored cell wall organization protein Candida_ALS PF05792.8 CCF46916.1 - 0.79 9.8 5.7 4.2 7.5 3.9 2.0 1 1 0 1 1 1 0 Candida agglutinin-like (ALS) HTH_psq PF05225.11 CCF46917.1 - 9.2e-14 50.7 0.0 2.1e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF46917.1 - 2.4e-10 40.0 0.0 4e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.1 CCF46917.1 - 0.0019 17.7 0.1 0.02 14.5 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 CCF46917.1 - 0.0074 16.2 0.0 0.054 13.5 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_8 PF02954.14 CCF46917.1 - 0.081 12.4 0.1 0.37 10.3 0.0 2.1 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family Phenol_Hydrox PF02332.13 CCF46920.1 - 0.076 12.2 1.0 0.078 12.2 0.7 1.1 1 0 0 1 1 1 0 Methane/Phenol/Toluene Hydroxylase Tropomyosin_1 PF12718.2 CCF46921.1 - 0.011 15.5 4.5 0.021 14.6 3.1 1.3 1 0 0 1 1 1 0 Tropomyosin like DUF2524 PF10732.4 CCF46921.1 - 0.013 15.5 0.2 0.042 13.9 0.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2524) WD40 PF00400.27 CCF46922.1 - 5e-21 73.7 1.8 9e-06 25.3 0.0 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat Sec16_C PF12931.2 CCF46922.1 - 1.3e-07 31.6 0.2 8.6e-07 28.9 0.1 2.0 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 RRM_1 PF00076.17 CCF46923.1 - 3.9e-18 64.8 0.0 5.3e-18 64.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF46923.1 - 3.6e-13 49.2 0.0 7e-13 48.3 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF46923.1 - 3.9e-10 39.4 0.0 5.6e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 CCF46923.1 - 0.065 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Limkain b1 Nup35_RRM_2 PF14605.1 CCF46923.1 - 0.14 11.9 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif B12D PF06522.6 CCF46924.1 - 1.2e-09 37.7 0.0 1.6e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit COX6B PF02297.12 CCF46925.1 - 2.5e-19 69.0 4.2 2.9e-19 68.8 2.9 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb APOBEC_C PF05240.9 CCF46925.1 - 0.014 14.7 2.0 0.018 14.4 1.2 1.5 1 1 0 1 1 1 0 APOBEC-like C-terminal domain ketoacyl-synt PF00109.21 CCF46925.1 - 0.13 11.7 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain Telomere_Sde2 PF13019.1 CCF46926.1 - 2.1e-68 229.1 0.9 3e-68 228.6 0.6 1.2 1 0 0 1 1 1 1 Telomere stability and silencing SbcD_C PF12320.3 CCF46926.1 - 0.1 12.6 2.7 3.5 7.7 1.4 2.4 2 0 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain S10_plectin PF03501.10 CCF46927.1 - 8.6e-42 140.9 0.2 1.5e-41 140.1 0.1 1.3 1 0 0 1 1 1 1 Plectin/S10 domain DUF3328 PF11807.3 CCF46928.1 - 4.5e-05 23.2 0.1 7e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF1096 PF06493.6 CCF46928.1 - 0.14 12.0 1.3 0.26 11.2 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1096) Acetyltransf_7 PF13508.1 CCF46930.1 - 7.2e-07 29.2 0.0 1.3e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CCF46930.1 - 0.00019 21.3 0.0 0.00028 20.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.1 CCF46930.1 - 0.00046 20.0 0.0 0.00089 19.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF46930.1 - 0.098 12.4 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Hemerythrin PF01814.18 CCF46932.1 - 1.4e-06 28.5 1.3 1.5e-06 28.3 0.5 1.4 2 0 0 2 2 2 1 Hemerythrin HHE cation binding domain DUF2383 PF09537.5 CCF46932.1 - 0.096 12.9 0.1 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) MFS_1 PF07690.11 CCF46933.1 - 4.1e-08 32.3 4.3 4.8e-08 32.1 3.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF46933.1 - 0.0028 16.1 0.2 0.0031 15.9 0.1 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein 7TM-7TMR_HD PF07698.6 CCF46933.1 - 0.032 13.6 0.6 0.039 13.3 0.4 1.1 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase DctQ PF04290.7 CCF46933.1 - 0.49 10.1 3.1 1 9.1 2.2 1.6 1 1 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component DUF4131 PF13567.1 CCF46933.1 - 5.8 6.2 8.4 71 2.7 5.7 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) UQ_con PF00179.21 CCF46934.1 - 1.9e-34 118.1 0.0 2.5e-34 117.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CCF46934.1 - 0.024 14.3 0.1 0.077 12.7 0.0 1.9 1 1 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.17 CCF46934.1 - 0.098 12.5 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 RWD domain Thioredoxin PF00085.15 CCF46935.1 - 3e-07 30.0 0.0 4.5e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.5 CCF46935.1 - 0.0062 16.0 0.0 0.0066 16.0 0.0 1.2 1 0 0 1 1 1 1 Redoxin Thioredoxin_9 PF14595.1 CCF46935.1 - 0.01 15.4 0.0 0.04 13.4 0.0 1.9 1 1 0 1 1 1 0 Thioredoxin DUF953 PF06110.6 CCF46935.1 - 0.041 13.3 0.3 0.26 10.7 0.2 1.9 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Thioredoxin_2 PF13098.1 CCF46935.1 - 0.056 13.6 0.0 0.69 10.1 0.0 2.1 1 1 0 1 1 1 0 Thioredoxin-like domain DUF718 PF05336.8 CCF46936.1 - 1.6e-32 111.4 0.2 1.9e-32 111.2 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF718) ArsA_ATPase PF02374.10 CCF46939.1 - 7.7e-44 149.9 1.2 8.6e-44 149.8 0.9 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AIP3 PF03915.8 CCF46939.1 - 0.0085 15.0 0.1 0.0098 14.8 0.1 1.1 1 0 0 1 1 1 1 Actin interacting protein 3 DUF3763 PF12592.3 CCF46939.1 - 0.12 12.0 0.1 0.3 10.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3763) DUF4183 PF13799.1 CCF46939.1 - 0.13 12.1 0.1 0.18 11.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4183) ParA PF10609.4 CCF46939.1 - 0.14 12.0 0.1 0.2 11.5 0.1 1.3 1 0 0 1 1 1 0 ParA/MinD ATPase like DUF1183 PF06682.7 CCF46940.1 - 4.4 6.8 10.4 4.6 6.7 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) Fungal_trans PF04082.13 CCF46941.1 - 3.1e-26 91.7 0.6 1.8e-25 89.3 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF46941.1 - 1.6e-06 27.9 10.5 3.3e-06 26.9 7.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Spt20 PF12090.3 CCF46941.1 - 0.0058 16.0 2.8 0.0094 15.3 1.9 1.3 1 0 0 1 1 1 1 Spt20 family DUF4557 PF15101.1 CCF46941.1 - 0.0076 16.1 7.8 0.014 15.2 5.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4557) Gal4_dimer PF03902.8 CCF46941.1 - 0.018 14.9 0.4 0.036 14.0 0.3 1.5 1 0 0 1 1 1 0 Gal4-like dimerisation domain DUF3801 PF12687.2 CCF46941.1 - 0.03 13.8 3.9 0.042 13.4 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) SAE2 PF08573.5 CCF46941.1 - 0.03 15.0 3.3 0.03 15.0 2.3 2.2 2 1 0 2 2 2 0 DNA repair protein endonuclease SAE2/CtIP C-terminus DUF775 PF05603.7 CCF46941.1 - 0.035 13.6 1.4 0.057 12.9 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF775) FimP PF09766.4 CCF46941.1 - 0.074 12.1 8.9 0.11 11.5 6.2 1.2 1 0 0 1 1 1 0 Fms-interacting protein Suf PF05843.9 CCF46941.1 - 0.1 12.3 4.6 0.13 11.9 3.2 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Kei1 PF08552.6 CCF46941.1 - 0.16 11.6 1.4 0.3 10.7 1.0 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Serinc PF03348.10 CCF46941.1 - 1 7.9 2.7 0.83 8.2 0.9 1.5 2 0 0 2 2 2 0 Serine incorporator (Serinc) Herpes_U44 PF04533.8 CCF46941.1 - 1.8 7.7 6.5 0.44 9.7 1.9 1.8 2 0 0 2 2 2 0 Herpes virus U44 protein BAF1_ABF1 PF04684.8 CCF46941.1 - 2.5 6.8 19.0 3.8 6.2 13.2 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Dickkopf_N PF04706.7 CCF46941.1 - 5 7.3 11.5 26 5.0 8.0 2.1 1 1 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region DUF4175 PF13779.1 CCF46941.1 - 6.8 4.2 20.2 9.8 3.7 14.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Glyco_trans_2_3 PF13632.1 CCF46942.1 - 1e-17 64.4 0.4 1.5e-17 63.9 0.3 1.3 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Dimerisation PF08100.6 CCF46945.1 - 0.0039 16.9 0.1 0.0075 16.0 0.1 1.5 1 0 0 1 1 1 1 Dimerisation domain HxlR PF01638.12 CCF46945.1 - 0.0064 16.0 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 HxlR-like helix-turn-helix DUF236 PF03057.9 CCF46945.1 - 0.035 14.0 0.1 0.058 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function XPG_N PF00752.12 CCF46946.1 - 5.2e-34 116.5 0.0 1.2e-33 115.3 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain UIM PF02809.15 CCF46946.1 - 0.0038 16.6 8.4 0.035 13.6 0.1 4.0 3 0 0 3 3 3 2 Ubiquitin interaction motif LSM PF01423.17 CCF46947.1 - 2.3e-06 27.0 0.0 3e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 CCF46947.1 - 0.022 14.6 0.0 0.031 14.1 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Big_1 PF02369.11 CCF46947.1 - 0.059 13.2 0.0 0.07 13.0 0.0 1.2 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) Pil1 PF13805.1 CCF46948.1 - 1.1e-134 447.7 3.5 1.6e-134 447.2 2.4 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 FAM92 PF06730.6 CCF46948.1 - 0.031 13.6 3.7 0.022 14.0 0.8 1.8 1 1 0 2 2 2 0 FAM92 protein US22 PF02393.11 CCF46952.1 - 0.032 14.2 0.3 0.034 14.1 0.2 1.0 1 0 0 1 1 1 0 US22 like GPI2 PF06432.6 CCF46954.1 - 1.3e-43 149.4 4.7 1.7e-43 149.0 3.2 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Herpes_US9 PF06072.6 CCF46954.1 - 0.086 12.6 0.4 0.15 11.9 0.3 1.3 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 ABC2_membrane PF01061.19 CCF46954.1 - 0.25 10.4 8.9 0.79 8.8 6.2 1.8 1 1 0 1 1 1 0 ABC-2 type transporter DUF202 PF02656.10 CCF46954.1 - 0.73 10.0 3.4 1 9.6 0.2 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF202) DUF4231 PF14015.1 CCF46954.1 - 2.6 8.0 4.7 1.3 9.0 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) RNase_H PF00075.19 CCF46955.1 - 2.3e-08 34.4 0.0 3.3e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.1 CCF46955.1 - 0.00079 19.1 1.2 0.047 13.4 0.1 2.7 2 1 0 2 2 2 1 Reverse transcriptase-like YdjC PF04794.7 CCF46955.1 - 0.078 12.4 0.0 0.11 11.9 0.0 1.3 1 1 0 1 1 1 0 YdjC-like protein DUF2622 PF11080.3 CCF46955.1 - 0.079 12.8 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2622) Pectate_lyase_3 PF12708.2 CCF46956.1 - 1.8e-65 221.2 15.4 8.7e-54 183.0 7.4 2.2 2 0 0 2 2 2 2 Pectate lyase superfamily protein Beta_helix PF13229.1 CCF46956.1 - 0.00059 19.6 13.6 0.002 17.9 8.6 2.1 1 1 0 1 1 1 1 Right handed beta helix region NosD PF05048.8 CCF46956.1 - 0.0011 18.1 8.6 0.0037 16.4 6.0 1.8 1 1 0 1 1 1 1 Periplasmic copper-binding protein (NosD) End_N_terminal PF12218.3 CCF46956.1 - 0.028 13.8 0.0 0.073 12.5 0.0 1.7 1 0 0 1 1 1 0 N terminal extension of bacteriophage endosialidase VMA21 PF09446.5 CCF46956.1 - 0.18 11.7 0.8 0.42 10.5 0.6 1.6 1 0 0 1 1 1 0 VMA21-like domain FMO-like PF00743.14 CCF46957.1 - 8.4e-37 126.5 0.0 6.3e-23 80.7 0.0 3.0 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 CCF46957.1 - 4.2e-21 75.9 0.0 4.7e-20 72.5 0.0 2.3 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CCF46957.1 - 1.7e-12 47.3 0.0 4.1e-10 39.6 0.0 2.4 2 1 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 CCF46957.1 - 3.1e-11 43.5 0.0 2.6e-10 40.5 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF46957.1 - 7.5e-08 31.7 0.1 4.7e-05 22.5 0.0 2.3 2 0 0 2 2 2 2 Thi4 family NAD_binding_8 PF13450.1 CCF46957.1 - 1.1e-07 31.7 0.0 2.3e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 CCF46957.1 - 5.2e-07 28.9 0.0 0.00034 19.6 0.0 2.8 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.19 CCF46957.1 - 1.6e-05 24.0 0.0 0.09 11.6 0.0 3.1 3 0 0 3 3 3 2 FAD dependent oxidoreductase Amino_oxidase PF01593.19 CCF46957.1 - 9.5e-05 21.6 0.0 0.0092 15.0 0.0 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.2 CCF46957.1 - 0.00013 21.1 0.0 0.00018 20.7 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 CCF46957.1 - 0.0016 18.8 0.3 0.028 14.8 0.0 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF46957.1 - 0.0062 15.0 0.3 0.013 13.9 0.0 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.19 CCF46957.1 - 0.045 12.5 0.0 0.37 9.5 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain DJ-1_PfpI PF01965.19 CCF46957.1 - 0.065 12.6 0.1 9.8 5.6 0.0 2.4 2 0 0 2 2 2 0 DJ-1/PfpI family FAD_binding_3 PF01494.14 CCF46957.1 - 0.08 11.9 0.0 0.21 10.5 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain NAD_Gly3P_dh_N PF01210.18 CCF46957.1 - 0.092 12.4 0.0 0.43 10.2 0.0 1.9 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Shikimate_DH PF01488.15 CCF46957.1 - 0.14 12.3 0.0 0.64 10.1 0.0 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Oxidored_FMN PF00724.15 CCF46958.1 - 0.0002 20.4 0.0 0.00026 20.1 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family MFS_1 PF07690.11 CCF46960.1 - 4.4e-31 107.8 10.2 4.4e-31 107.8 7.1 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily LVIVD PF08309.6 CCF46961.1 - 0.027 13.4 4.4 4.3 6.4 1.0 3.1 2 1 1 3 3 3 0 LVIVD repeat Prok-E2_A PF14457.1 CCF46962.1 - 0.07 12.6 0.5 0.46 9.9 0.4 2.0 1 1 0 1 1 1 0 Prokaryotic E2 family A CTDII PF01556.13 CCF46963.1 - 1.1e-06 28.4 0.1 1.3e-06 28.2 0.0 1.0 1 0 0 1 1 1 1 DnaJ C terminal domain LTXXQ PF07813.7 CCF46963.1 - 0.095 13.1 0.0 0.095 13.1 0.0 1.0 1 0 0 1 1 1 0 LTXXQ motif family protein HMGL-like PF00682.14 CCF46965.1 - 1.8e-33 116.1 0.7 3.5e-33 115.2 0.5 1.5 1 0 0 1 1 1 1 HMGL-like Orbi_NS1 PF01718.11 CCF46965.1 - 0.11 10.4 0.0 0.16 9.9 0.0 1.1 1 0 0 1 1 1 0 Orbivirus non-structural protein NS1, or hydrophobic tubular protein AbfB PF05270.8 CCF46966.1 - 0.017 14.8 0.1 0.021 14.5 0.1 1.1 1 0 0 1 1 1 0 Alpha-L-arabinofuranosidase B (ABFB) Amidohydro_5 PF13594.1 CCF46967.1 - 1.8e-13 50.0 0.0 4e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 CCF46967.1 - 2e-10 40.8 0.1 2.6e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 CCF46967.1 - 3.4e-06 27.3 0.5 5.6e-06 26.5 0.3 1.4 1 0 0 1 1 1 1 Amidohydrolase TPR_4 PF07721.9 CCF46969.1 - 0.11 13.0 0.3 0.11 13.0 0.2 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TraQ PF09679.5 CCF46969.1 - 0.21 11.5 0.9 0.34 10.8 0.1 1.7 2 0 0 2 2 2 0 Type-F conjugative transfer system pilin chaperone (TraQ) FGGY_C PF02782.11 CCF46971.1 - 3.8e-46 157.1 0.6 6.6e-46 156.4 0.4 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 CCF46971.1 - 2.3e-25 89.3 0.5 1.1e-23 83.8 0.4 2.8 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.15 CCF46971.1 - 0.081 12.2 0.0 0.25 10.5 0.0 1.8 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family VTC PF09359.5 CCF46972.1 - 1e-92 310.2 0.9 1.7e-92 309.4 0.6 1.4 1 0 0 1 1 1 1 VTC domain SPX PF03105.14 CCF46972.1 - 1.4e-15 57.8 15.4 1.4e-15 57.8 10.7 4.4 3 1 0 3 3 3 1 SPX domain DUF202 PF02656.10 CCF46972.1 - 2e-10 40.7 2.3 2e-10 40.7 1.6 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF202) CCDC155 PF14662.1 CCF46972.1 - 0.024 14.2 5.5 0.48 9.9 0.5 2.4 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 NPV_P10 PF05531.7 CCF46972.1 - 0.41 10.9 2.0 7.5 6.8 0.0 2.7 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein TauD PF02668.11 CCF46973.1 - 1.4e-24 87.2 0.0 2e-24 86.6 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family PK_C PF02887.11 CCF46973.1 - 0.16 11.5 0.1 1.2 8.6 0.1 2.1 2 0 0 2 2 2 0 Pyruvate kinase, alpha/beta domain Cyto_heme_lyase PF01265.12 CCF46978.1 - 1.8e-74 250.5 0.0 2.2e-74 250.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase DEC-1_N PF04625.8 CCF46978.1 - 2.3 6.8 7.5 3.1 6.3 5.2 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Axin_b-cat_bind PF08833.5 CCF46979.1 - 0.055 13.1 1.1 0.44 10.2 0.1 2.3 2 1 0 2 2 2 0 Axin beta-catenin binding domain CorA PF01544.13 CCF46980.1 - 0.0016 17.5 6.2 0.002 17.1 4.3 1.3 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein FlhD PF05247.8 CCF46980.1 - 0.026 14.5 0.3 0.039 13.9 0.2 1.3 1 0 0 1 1 1 0 Flagellar transcriptional activator (FlhD) EamA PF00892.15 CCF46980.1 - 0.052 13.5 3.5 0.069 13.1 2.4 1.1 1 0 0 1 1 1 0 EamA-like transporter family Cation_ATPase_C PF00689.16 CCF46980.1 - 0.21 11.1 5.5 0.27 10.7 3.8 1.1 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus Cellulase PF00150.13 CCF46982.1 - 4.1e-08 32.7 0.0 6.2e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Amidohydro_1 PF01979.15 CCF46983.1 - 1.5e-08 34.7 0.0 1.7e-08 34.5 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 CCF46983.1 - 1.5e-07 30.9 0.0 1.7e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 CCF46983.1 - 0.0066 16.5 0.0 0.0083 16.1 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase Pectinesterase PF01095.14 CCF46985.1 - 1.4e-09 36.9 1.4 1.6e-09 36.7 0.9 1.0 1 0 0 1 1 1 1 Pectinesterase Apelin PF15360.1 CCF46986.1 - 0.53 10.5 11.9 1.6 8.9 0.5 2.4 1 1 1 2 2 2 0 APJ endogenous ligand TFIID-18kDa PF02269.11 CCF46987.1 - 1.4e-17 63.2 0.0 2.4e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Bromo_TP PF07524.8 CCF46987.1 - 3.9e-05 23.3 0.0 8.8e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 Bromodomain associated CBFD_NFYB_HMF PF00808.18 CCF46987.1 - 0.0022 18.0 0.3 0.016 15.2 0.0 2.2 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Transcrip_reg PF01709.15 CCF46987.1 - 0.0024 17.0 3.1 0.003 16.7 2.2 1.1 1 0 0 1 1 1 1 Transcriptional regulator CENP-S PF15630.1 CCF46987.1 - 0.0035 17.4 0.0 0.0069 16.5 0.0 1.4 1 0 0 1 1 1 1 Kinetochore component CENP-S Histone PF00125.19 CCF46987.1 - 0.029 14.4 0.0 0.052 13.6 0.0 1.4 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 DUF1242 PF06842.7 CCF46988.1 - 1.6e-15 56.3 0.6 1.8e-15 56.1 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) zf-LITAF-like PF10601.4 CCF46988.1 - 0.091 12.6 0.3 0.093 12.6 0.2 1.1 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain DUF3317 PF11779.3 CCF46988.1 - 0.27 10.6 1.3 0.26 10.7 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3317) Tcp11 PF05794.8 CCF46989.1 - 1.5e-83 280.9 0.0 2.3e-79 267.2 0.2 2.1 2 0 0 2 2 2 2 T-complex protein 11 Glyco_hydro_11 PF00457.12 CCF46991.1 - 1.2e-73 246.3 19.3 1.4e-73 246.2 13.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 HTH_psq PF05225.11 CCF46995.1 - 2.1e-12 46.3 0.1 3.6e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_1 PF03184.14 CCF46995.1 - 1.1e-08 34.4 0.0 1.5e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 CCF46995.1 - 7.2e-08 32.1 0.2 2.1e-07 30.6 0.0 1.9 2 1 0 2 2 2 1 Tc5 transposase DNA-binding domain Fn3-like PF14310.1 CCF46996.1 - 1.2e-21 76.4 0.5 2.2e-21 75.5 0.3 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF11 PF01345.13 CCF46996.1 - 0.028 14.4 0.9 0.23 11.5 0.9 2.1 1 1 1 2 2 2 0 Domain of unknown function DUF11 DUF4352 PF11611.3 CCF46996.1 - 0.057 13.5 0.0 0.11 12.5 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4352) Msg2_C PF12373.3 CCF46996.1 - 0.085 12.0 1.5 2.4 7.4 0.0 2.6 2 0 0 2 2 2 0 Major surface glycoprotein 2 C terminal Cytochrom_B562 PF07361.6 CCF46999.1 - 0.0085 16.4 8.5 0.0085 16.4 5.9 2.2 1 1 1 2 2 2 1 Cytochrome b562 ARGLU PF15346.1 CCF46999.1 - 0.2 11.4 10.4 0.29 10.8 7.2 1.2 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 Glyco_hydro_61 PF03443.9 CCF47000.1 - 2e-66 223.9 0.0 2.3e-66 223.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 NPCBM_assoc PF10633.4 CCF47000.1 - 0.0081 16.1 0.1 0.22 11.6 0.0 2.8 3 0 0 3 3 3 1 NPCBM-associated, NEW3 domain of alpha-galactosidase SUV3_C PF12513.3 CCF47001.1 - 1.5e-14 53.1 1.1 2.2e-14 52.6 0.1 1.9 2 0 0 2 2 2 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.26 CCF47001.1 - 3e-05 23.7 0.0 8.6e-05 22.3 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Nha1_C PF08619.5 CCF47002.1 - 0.091 12.0 0.4 0.13 11.4 0.3 1.3 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus MFS_1 PF07690.11 CCF47007.1 - 6.7e-25 87.5 56.7 1.2e-24 86.7 28.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3814 PF12769.2 CCF47007.1 - 0.033 14.3 3.6 0.16 12.1 2.5 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3814) NmrA PF05368.8 CCF47008.1 - 7.7e-22 77.6 0.4 1e-21 77.2 0.2 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF47008.1 - 3.2e-21 76.1 1.0 3.3e-20 72.8 0.6 2.0 1 1 1 2 2 2 1 NADH(P)-binding Epimerase PF01370.16 CCF47008.1 - 9e-08 31.8 0.1 2.1e-06 27.3 0.1 2.4 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.19 CCF47008.1 - 0.00039 20.6 0.2 0.00083 19.6 0.2 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.12 CCF47008.1 - 0.00045 19.1 0.1 0.006 15.5 0.1 2.1 2 0 0 2 2 2 1 RmlD substrate binding domain CoA_binding_2 PF13380.1 CCF47008.1 - 0.0021 18.2 1.0 0.0049 17.0 0.7 1.6 1 0 0 1 1 1 1 CoA binding domain Saccharop_dh PF03435.13 CCF47008.1 - 0.0094 14.9 0.2 0.013 14.5 0.2 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase DapB_N PF01113.15 CCF47008.1 - 0.016 15.1 0.6 0.041 13.8 0.4 1.8 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus 3Beta_HSD PF01073.14 CCF47008.1 - 0.029 13.0 0.1 0.083 11.5 0.1 1.7 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family FAD_binding_3 PF01494.14 CCF47008.1 - 0.031 13.3 0.6 0.053 12.5 0.4 1.3 1 0 0 1 1 1 0 FAD binding domain DFP PF04127.10 CCF47008.1 - 0.032 13.8 0.6 0.064 12.8 0.4 1.5 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein THF_DHG_CYH_C PF02882.14 CCF47008.1 - 0.05 12.6 1.8 0.099 11.7 0.6 2.0 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.13 CCF47008.1 - 0.088 12.4 0.5 0.16 11.5 0.4 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Trp_DMAT PF11991.3 CCF47009.1 - 6.8e-56 190.0 0.0 7.8e-56 189.8 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase ABC_membrane PF00664.18 CCF47013.1 - 8e-06 25.4 6.4 5.3e-05 22.7 4.4 2.2 1 1 0 1 1 1 1 ABC transporter transmembrane region PGA2 PF07543.7 CCF47014.1 - 0.051 13.3 9.5 0.055 13.2 6.6 1.1 1 0 0 1 1 1 0 Protein trafficking PGA2 NAM-associated PF14303.1 CCF47014.1 - 1.2 9.4 5.0 1.5 9.1 3.5 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain LIN37 PF15306.1 CCF47014.1 - 1.6 8.7 4.3 1.7 8.6 2.9 1.1 1 0 0 1 1 1 0 LIN37 DUF1510 PF07423.6 CCF47014.1 - 5.8 6.2 10.8 6.5 6.0 7.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) MFS_1 PF07690.11 CCF47015.1 - 0.0018 17.0 0.4 0.0024 16.6 0.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily UCH PF00443.24 CCF47017.1 - 1.6e-75 253.6 0.0 9.9e-75 251.1 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CCF47017.1 - 2.4e-18 66.5 0.0 9.1e-09 35.1 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.7 CCF47017.1 - 5.9e-06 26.6 0.0 1.5e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 DUSP domain TMEM51 PF15345.1 CCF47018.1 - 0.14 11.8 3.5 0.32 10.6 2.4 1.6 1 0 0 1 1 1 0 Transmembrane protein 51 SCIMP PF15050.1 CCF47018.1 - 0.49 10.3 3.2 0.78 9.6 1.4 1.9 1 1 0 1 1 1 0 SCIMP protein CoA_transf_3 PF02515.12 CCF47021.1 - 0.0057 15.9 1.2 0.0087 15.3 0.3 1.7 2 0 0 2 2 2 1 CoA-transferase family III DUF3632 PF12311.3 CCF47026.1 - 0.095 12.5 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3632) Peptidase_S8 PF00082.17 CCF47027.1 - 0.016 14.3 0.0 0.018 14.1 0.0 1.2 1 0 0 1 1 1 0 Subtilase family Pyr_redox PF00070.22 CCF47028.1 - 1.9e-13 50.6 0.0 3.2e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CCF47028.1 - 1.8e-08 34.5 0.1 0.0025 17.7 0.1 3.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF47028.1 - 2.5e-06 26.6 0.1 0.0095 14.8 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Trp_halogenase PF04820.9 CCF47028.1 - 5.2e-05 22.0 0.0 0.21 10.1 0.1 2.1 1 1 1 2 2 2 2 Tryptophan halogenase K_oxygenase PF13434.1 CCF47028.1 - 6e-05 22.1 0.0 7.9e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.1 CCF47028.1 - 8.6e-05 22.6 0.0 0.026 14.5 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CCF47028.1 - 0.00013 21.0 0.0 0.072 11.9 0.0 2.2 1 1 1 2 2 2 2 Lycopene cyclase protein NAD_binding_7 PF13241.1 CCF47028.1 - 0.025 14.8 0.1 0.11 12.7 0.0 1.9 2 0 0 2 2 2 0 Putative NAD(P)-binding NAD_binding_9 PF13454.1 CCF47028.1 - 0.031 14.0 0.1 2.6 7.8 0.0 2.3 1 1 1 2 2 2 0 FAD-NAD(P)-binding TrkA_N PF02254.13 CCF47028.1 - 0.061 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Asparaginase PF00710.15 CCF47029.1 - 3.1e-30 105.1 0.0 3.6e-30 104.9 0.0 1.0 1 0 0 1 1 1 1 Asparaginase SR-25 PF10500.4 CCF47030.1 - 0.018 14.5 10.1 0.023 14.1 7.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pex14_N PF04695.8 CCF47030.1 - 0.97 9.4 7.7 0.66 10.0 4.2 1.6 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Spc7_N PF15402.1 CCF47030.1 - 2 6.3 7.4 2.6 5.9 5.1 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF3446 PF11928.3 CCF47030.1 - 9.8 6.4 18.9 5.6 7.2 9.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3446) Pectate_lyase PF03211.8 CCF47031.1 - 1.8e-71 240.0 7.5 2.2e-71 239.7 5.2 1.0 1 0 0 1 1 1 1 Pectate lyase PC4 PF02229.11 CCF47031.1 - 0.054 12.7 0.1 0.098 11.9 0.1 1.3 1 0 0 1 1 1 0 Transcriptional Coactivator p15 (PC4) Beta_elim_lyase PF01212.16 CCF47032.1 - 2.2e-21 76.2 0.0 2.6e-21 76.0 0.0 1.0 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 CCF47032.1 - 0.0018 16.6 0.0 0.0024 16.2 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 CCF47032.1 - 0.0042 16.1 0.0 0.0048 15.9 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family DUF1484 PF07363.6 CCF47033.1 - 0.04 14.2 1.5 0.058 13.7 0.6 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1484) TMCO5 PF14992.1 CCF47033.1 - 0.083 12.0 4.5 0.092 11.8 3.1 1.0 1 0 0 1 1 1 0 TMCO5 family DMPK_coil PF08826.5 CCF47033.1 - 0.21 11.5 3.1 1.1 9.2 0.0 2.2 1 1 1 2 2 2 0 DMPK coiled coil domain like Phage_lysis PF03245.8 CCF47033.1 - 0.38 10.7 7.0 1.6 8.7 1.6 2.1 1 1 1 2 2 2 0 Bacteriophage Rz lysis protein YaaC PF14175.1 CCF47034.1 - 4.4 6.1 9.6 2.1 7.2 5.1 1.6 2 0 0 2 2 2 0 YaaC-like Protein WD40 PF00400.27 CCF47035.1 - 3.7e-09 36.1 0.1 0.081 12.8 0.0 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat PD40 PF07676.7 CCF47035.1 - 0.078 12.6 0.0 0.4 10.4 0.0 2.1 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat PfkB PF00294.19 CCF47036.1 - 3.7e-09 36.1 0.1 7.4e-09 35.1 0.1 1.5 1 1 0 1 1 1 1 pfkB family carbohydrate kinase DUF3473 PF11959.3 CCF47036.1 - 0.15 11.4 0.0 0.81 9.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3473) RTA1 PF04479.8 CCF47037.1 - 3.3e-37 128.1 2.5 4.7e-37 127.6 1.7 1.1 1 0 0 1 1 1 1 RTA1 like protein AAA PF00004.24 CCF47039.1 - 5.3e-17 62.2 0.0 2.3e-16 60.2 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.6 CCF47039.1 - 7.3e-13 48.3 0.0 1.9e-12 47.0 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 CCF47039.1 - 4.2e-11 42.7 0.0 1.8e-10 40.7 0.0 2.0 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.1 CCF47039.1 - 3.5e-07 30.4 0.0 1.8e-05 24.8 0.0 3.1 2 2 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CCF47039.1 - 3e-05 23.6 0.0 6.6e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain DNA_pol3_delta PF06144.8 CCF47039.1 - 4e-05 23.2 0.0 7.3e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_14 PF13173.1 CCF47039.1 - 4.9e-05 23.2 0.0 8.6e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.4 CCF47039.1 - 0.00024 20.2 0.0 0.00045 19.2 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.1 CCF47039.1 - 0.00031 20.3 0.0 0.00058 19.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF47039.1 - 0.00048 20.1 0.0 0.015 15.3 0.0 2.7 2 1 0 3 3 3 1 AAA ATPase domain Rad17 PF03215.10 CCF47039.1 - 0.00069 18.4 0.1 0.42 9.2 0.0 2.2 1 1 1 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_17 PF13207.1 CCF47039.1 - 0.00072 20.3 0.0 0.0019 19.0 0.0 1.9 2 1 0 2 2 1 1 AAA domain AAA_25 PF13481.1 CCF47039.1 - 0.0045 16.4 0.1 0.02 14.3 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 CCF47039.1 - 0.0055 16.6 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 CCF47039.1 - 0.0055 16.3 0.4 0.012 15.2 0.3 1.7 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CCF47039.1 - 0.0057 16.9 0.0 0.017 15.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 CCF47039.1 - 0.0059 16.3 0.3 0.038 13.7 0.1 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 CCF47039.1 - 0.0074 15.4 0.0 0.36 9.9 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 CCF47039.1 - 0.009 14.7 0.0 0.8 8.3 0.0 2.2 2 0 0 2 2 2 1 TIP49 C-terminus AAA_30 PF13604.1 CCF47039.1 - 0.011 15.2 0.0 0.071 12.6 0.0 2.2 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 CCF47039.1 - 0.017 15.2 0.0 0.046 13.9 0.0 1.7 1 1 0 1 1 1 0 RNA helicase RuvB_N PF05496.7 CCF47039.1 - 0.073 12.1 0.1 0.2 10.6 0.0 1.8 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 CCF47039.1 - 0.12 12.2 0.0 0.23 11.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_3 PF07726.6 CCF47039.1 - 0.13 11.8 0.0 0.87 9.1 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) BNR PF02012.15 CCF47040.1 - 3.4e-07 29.0 3.3 0.2 11.6 0.0 4.6 3 0 0 3 3 3 3 BNR/Asp-box repeat DUF4185 PF13810.1 CCF47040.1 - 0.00033 19.6 0.7 0.027 13.3 0.0 3.0 2 1 1 3 3 3 1 Domain of unknown function (DUF4185) BNR_2 PF13088.1 CCF47040.1 - 0.01 15.1 0.4 0.21 10.8 0.3 2.5 1 1 0 1 1 1 0 BNR repeat-like domain Kelch_3 PF13415.1 CCF47040.1 - 0.071 13.3 3.9 1.3 9.2 0.1 4.1 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_4 PF13418.1 CCF47040.1 - 0.51 10.1 4.2 0.42 10.4 0.3 2.9 2 1 1 3 3 3 0 Galactose oxidase, central domain Kelch_6 PF13964.1 CCF47040.1 - 3.7 7.8 6.6 8.5 6.7 0.1 4.3 5 2 0 5 5 5 0 Kelch motif Pkinase PF00069.20 CCF47043.1 - 5.5e-25 87.9 0.0 7.6e-25 87.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF47043.1 - 1e-18 67.3 0.0 1.4e-18 66.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 CCF47043.1 - 0.0029 16.6 0.0 0.0047 16.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 CCF47043.1 - 0.019 13.9 0.0 0.036 13.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Pox_ser-thr_kin PF05445.6 CCF47043.1 - 0.096 11.4 0.0 0.15 10.7 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF3115 PF11312.3 CCF47044.1 - 5.3e-05 22.2 0.0 7.7e-05 21.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3115) DUF2880 PF11082.3 CCF47044.1 - 0.03 14.2 2.0 0.061 13.2 1.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2880) Cu_amine_oxid PF01179.15 CCF47045.1 - 3.3e-37 128.2 1.6 3.8e-37 128.0 1.1 1.0 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Xpo1 PF08389.7 CCF47046.1 - 2.4e-08 34.0 6.0 0.00011 22.1 0.0 4.3 4 0 0 4 4 4 2 Exportin 1-like protein HEAT_2 PF13646.1 CCF47046.1 - 0.00036 20.7 0.2 0.59 10.4 0.0 4.0 4 0 0 4 4 4 1 HEAT repeats IBN_N PF03810.14 CCF47046.1 - 0.00052 19.8 0.4 0.0038 17.0 0.2 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain WD40 PF00400.27 CCF47047.1 - 2.4e-08 33.5 1.5 0.00038 20.2 0.0 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat DUF1917 PF08939.5 CCF47048.1 - 2.4e-64 217.3 0.2 5e-64 216.3 0.2 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1917) Mhr1 PF12829.2 CCF47048.1 - 0.12 12.2 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulation of mitochondrial recombination Acetyltransf_1 PF00583.19 CCF47049.1 - 9e-19 67.3 0.0 1.3e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CCF47049.1 - 1e-10 41.5 0.0 1.5e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CCF47049.1 - 5.7e-10 38.8 0.0 9.2e-10 38.1 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 CCF47049.1 - 7e-10 39.0 0.0 1e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 CCF47049.1 - 1e-09 38.6 0.0 1.2e-09 38.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 CCF47049.1 - 3e-07 30.4 0.0 3.6e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 CCF47049.1 - 4.5e-07 29.7 0.0 7.8e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 CCF47049.1 - 0.0011 18.8 0.0 0.0022 17.8 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.1 CCF47049.1 - 0.017 15.0 0.0 0.025 14.5 0.0 1.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.2 CCF47049.1 - 0.12 11.1 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase AAR2 PF05282.6 CCF47051.1 - 1.3e-08 34.2 0.0 1.7e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 AAR2 protein Baculo_p74_N PF08404.5 CCF47051.1 - 0.048 12.4 0.0 0.067 11.9 0.0 1.2 1 0 0 1 1 1 0 Baculoviridae P74 N-terminal ADH_zinc_N PF00107.21 CCF47052.1 - 3.5e-07 29.8 0.0 7.5e-07 28.7 0.0 1.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase zf-rbx1 PF12678.2 CCF47053.1 - 4.3e-10 39.5 0.2 7.6e-10 38.7 0.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 CCF47053.1 - 4.2e-09 36.0 8.8 5.7e-08 32.4 6.1 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 CCF47053.1 - 8.3e-08 31.7 0.5 1.4e-07 31.0 0.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF47053.1 - 1.2e-07 31.2 2.1 1.5e-06 27.7 0.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF47053.1 - 1.7e-07 30.8 2.7 8.1e-07 28.6 1.9 2.0 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CCF47053.1 - 3.4e-05 23.7 2.4 3.4e-05 23.7 1.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CCF47053.1 - 0.0078 16.0 0.9 0.0078 16.0 0.6 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF2921 PF11145.3 CCF47053.1 - 0.011 13.4 0.6 0.014 13.1 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2921) zf-RING_UBOX PF13445.1 CCF47053.1 - 0.014 15.1 0.7 0.014 15.1 0.5 2.8 2 1 1 3 3 3 0 RING-type zinc-finger zf-RING_6 PF14835.1 CCF47053.1 - 0.088 12.6 2.0 0.55 10.0 0.1 2.3 1 1 1 2 2 2 0 zf-RING of BARD1-type protein FANCL_C PF11793.3 CCF47053.1 - 0.88 9.5 6.4 1.1 9.2 2.4 2.4 2 1 0 2 2 2 0 FANCL C-terminal domain RINGv PF12906.2 CCF47053.1 - 2.6 8.1 5.7 0.61 10.1 0.9 2.1 2 0 0 2 2 2 0 RING-variant domain APG5 PF04106.7 CCF47054.1 - 1.9e-19 69.9 0.2 3.6e-18 65.7 0.2 2.2 1 1 0 1 1 1 1 Autophagy protein Apg5 Serglycin PF04360.7 CCF47055.1 - 0.065 12.9 4.6 0.11 12.2 3.2 1.4 1 0 0 1 1 1 0 Serglycin Glyco_hydro_28 PF00295.12 CCF47056.1 - 1.5e-14 53.6 0.0 9.2e-14 51.1 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.2 CCF47056.1 - 0.0024 18.0 0.5 0.0089 16.1 0.4 2.0 1 1 0 1 1 1 1 Pectate lyase superfamily protein FAM60A PF15396.1 CCF47057.1 - 1.6 8.4 5.8 2.2 7.9 4.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Gag_spuma PF03276.9 CCF47057.1 - 6.8 4.8 32.4 13 4.0 22.4 1.4 1 0 0 1 1 1 0 Spumavirus gag protein Lipase_GDSL PF00657.17 CCF47058.1 - 1e-17 64.7 0.0 1.7e-17 64.0 0.0 1.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.1 CCF47058.1 - 2e-06 28.0 3.0 5.3e-06 26.6 2.1 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Fels1 PF05666.6 CCF47058.1 - 0.11 11.8 0.1 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Fels-1 Prophage Protein-like Aminotran_1_2 PF00155.16 CCF47059.1 - 2.8e-64 217.3 0.0 3.3e-64 217.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Glyco_hydro_76 PF03663.9 CCF47060.1 - 6e-91 305.5 12.4 7.1e-91 305.3 8.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.8 CCF47060.1 - 0.21 10.6 6.5 0.22 10.5 0.1 2.8 2 1 1 3 3 3 0 Glycosyl Hydrolase Family 88 Peptidase_A22B PF04258.8 CCF47062.1 - 2e-42 145.6 6.2 1.2e-41 143.1 4.3 1.9 1 1 0 1 1 1 1 Signal peptide peptidase DUF1119 PF06550.6 CCF47062.1 - 7.9 5.5 10.1 12 4.9 0.1 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF1119) IGF2_C PF08365.6 CCF47065.1 - 0.061 13.0 3.9 0.052 13.3 2.1 1.4 1 1 0 1 1 1 0 Insulin-like growth factor II E-peptide zf-Tim10_DDP PF02953.10 CCF47066.1 - 3.7e-20 70.9 3.6 4.5e-20 70.7 2.5 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Collagen PF01391.13 CCF47067.1 - 1.5 8.4 16.8 9.9 5.7 11.6 2.2 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) FbpA PF05833.6 CCF47068.1 - 1.4e-05 23.8 0.0 1.7e-05 23.5 0.0 1.0 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DDE_1 PF03184.14 CCF47071.1 - 1.8e-55 187.4 0.0 2.7e-55 186.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 CCF47071.1 - 1.7e-08 34.3 0.0 3.4e-08 33.3 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease Glyco_hydro_2_C PF02836.12 CCF47072.1 - 0.025 13.4 0.0 0.043 12.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Voltage_CLC PF00654.15 CCF47074.1 - 6.2e-50 170.2 3.0 6.2e-50 170.2 2.0 2.2 2 1 0 2 2 2 1 Voltage gated chloride channel Abi PF02517.11 CCF47074.1 - 0.055 13.6 0.1 0.055 13.6 0.1 2.4 2 1 0 2 2 2 0 CAAX protease self-immunity MFS_1 PF07690.11 CCF47075.1 - 9.8e-33 113.3 35.4 9.8e-33 113.3 24.6 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF1228 PF06779.9 CCF47075.1 - 0.013 15.5 6.4 1.4 9.0 0.1 3.4 2 2 2 4 4 4 0 Protein of unknown function (DUF1228) AAA_33 PF13671.1 CCF47076.1 - 1.5e-11 44.3 0.0 1.9e-11 43.9 0.0 1.0 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 CCF47076.1 - 1.9e-08 33.6 0.0 7.4e-08 31.7 0.0 1.7 1 1 0 1 1 1 1 Zeta toxin AAA_17 PF13207.1 CCF47076.1 - 8.9e-08 32.9 0.0 1.2e-07 32.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CCF47076.1 - 0.00039 20.7 0.1 0.00086 19.6 0.1 1.7 1 1 0 1 1 1 1 AAA domain CoaE PF01121.15 CCF47076.1 - 0.0017 17.7 0.0 0.0019 17.6 0.0 1.2 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA PF00004.24 CCF47076.1 - 0.0031 17.7 0.1 0.0065 16.6 0.0 1.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SKI PF01202.17 CCF47076.1 - 0.0076 16.1 0.0 0.0081 16.0 0.0 1.3 1 0 0 1 1 1 1 Shikimate kinase KTI12 PF08433.5 CCF47076.1 - 0.01 15.0 0.0 0.017 14.3 0.0 1.3 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_28 PF13521.1 CCF47076.1 - 0.011 15.6 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 CCF47076.1 - 0.017 15.2 0.0 0.021 14.9 0.0 1.3 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.13 CCF47076.1 - 0.026 14.0 0.0 0.027 14.0 0.0 1.1 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.22 CCF47076.1 - 0.032 14.5 0.0 0.041 14.1 0.0 1.2 1 0 0 1 1 1 0 ABC transporter APS_kinase PF01583.15 CCF47076.1 - 0.049 13.2 0.0 0.052 13.1 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase Mg_chelatase PF01078.16 CCF47076.1 - 0.056 12.6 0.0 0.075 12.1 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.1 CCF47076.1 - 0.068 12.7 0.1 0.15 11.5 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_10 PF12846.2 CCF47076.1 - 0.078 12.4 0.1 0.11 11.9 0.0 1.5 1 1 0 1 1 1 0 AAA-like domain RNA_helicase PF00910.17 CCF47076.1 - 0.079 13.1 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 RNA helicase Mycobact_memb PF05423.8 CCF47076.1 - 0.082 12.6 0.0 0.089 12.5 0.0 1.2 1 0 0 1 1 1 0 Mycobacterium membrane protein AAA_24 PF13479.1 CCF47076.1 - 0.083 12.4 0.0 0.083 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain CPT PF07931.7 CCF47076.1 - 0.085 12.4 0.1 1.2 8.7 0.0 2.0 1 1 1 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_19 PF13245.1 CCF47076.1 - 0.086 12.6 0.2 0.17 11.6 0.1 1.5 1 0 0 1 1 1 0 Part of AAA domain DUF815 PF05673.8 CCF47076.1 - 0.091 11.6 0.0 1.7 7.5 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF815) AAA_25 PF13481.1 CCF47076.1 - 0.24 10.8 0.7 0.28 10.5 0.5 1.5 1 1 0 1 1 1 0 AAA domain RTA1 PF04479.8 CCF47077.1 - 1.3e-35 122.9 5.3 1.9e-35 122.4 3.7 1.2 1 0 0 1 1 1 1 RTA1 like protein Zn_clus PF00172.13 CCF47078.1 - 4.5e-07 29.6 8.3 4.5e-07 29.6 5.7 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF47078.1 - 0.00028 19.6 0.0 0.00041 19.0 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain p450 PF00067.17 CCF47079.1 - 0.00011 20.8 0.0 0.00013 20.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3638 PF12340.3 CCF47080.1 - 2e-98 327.9 0.5 3.3e-98 327.2 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.3 CCF47080.1 - 2.5e-17 61.6 0.2 7e-17 60.2 0.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) Chromadorea_ALT PF05535.7 CCF47080.1 - 0.037 14.1 0.0 0.099 12.7 0.0 1.7 1 0 0 1 1 1 0 Chromadorea ALT protein peroxidase PF00141.18 CCF47082.1 - 2e-28 99.4 0.2 6.4e-28 97.7 0.1 1.6 1 1 0 1 1 1 1 Peroxidase DUF3415 PF11895.3 CCF47082.1 - 1.7e-05 24.5 0.0 3.5e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3415) DUF1929 PF09118.6 CCF47083.1 - 2e-24 85.5 0.1 3.8e-24 84.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_1 PF01344.20 CCF47083.1 - 3.1e-17 61.8 0.2 1.4e-08 34.1 0.0 4.4 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.1 CCF47083.1 - 8.7e-16 57.3 3.5 2.7e-05 24.1 0.0 4.7 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.1 CCF47083.1 - 4.3e-14 52.0 3.8 2.8e-05 23.7 0.0 5.1 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.10 CCF47083.1 - 3.1e-12 45.7 2.6 5.3e-06 25.9 0.1 4.7 4 0 0 4 4 4 2 Kelch motif Glyoxal_oxid_N PF07250.6 CCF47083.1 - 1e-10 41.1 0.7 4.3e-07 29.2 0.4 2.3 2 0 0 2 2 2 2 Glyoxal oxidase N-terminus Kelch_3 PF13415.1 CCF47083.1 - 2.7e-07 30.5 2.5 0.0043 17.1 0.0 4.3 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.1 CCF47083.1 - 0.0002 21.2 6.2 2 8.4 0.1 4.6 5 0 0 5 5 5 2 Kelch motif PIG-S PF10510.4 CCF47086.1 - 0.028 13.1 0.0 0.038 12.6 0.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein Tub_2 PF04525.7 CCF47087.1 - 1.3e-22 80.1 0.0 1.6e-22 79.8 0.0 1.0 1 0 0 1 1 1 1 Tubby C 2 UNC45-central PF11701.3 CCF47089.1 - 2.2e-48 163.8 0.0 4.2e-48 162.9 0.0 1.5 1 0 0 1 1 1 1 Myosin-binding striated muscle assembly central NACHT PF05729.7 CCF47091.1 - 0.0021 17.7 0.2 0.0041 16.8 0.1 1.5 1 0 0 1 1 1 1 NACHT domain KAP_NTPase PF07693.9 CCF47091.1 - 0.0043 16.1 0.3 0.0062 15.5 0.2 1.3 1 0 0 1 1 1 1 KAP family P-loop domain TcdB_N PF12918.2 CCF47091.1 - 0.017 15.1 0.4 11 6.1 0.0 3.1 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain AAA_16 PF13191.1 CCF47091.1 - 0.13 12.2 3.8 0.085 12.8 0.8 2.0 1 1 1 2 2 2 0 AAA ATPase domain Ank_2 PF12796.2 CCF47092.1 - 5.6e-58 193.2 3.3 1.3e-19 70.2 1.8 6.9 2 2 3 5 5 5 4 Ankyrin repeats (3 copies) Ank PF00023.25 CCF47092.1 - 9.5e-45 148.2 11.5 5.1e-08 32.3 0.1 11.8 12 0 0 12 12 12 6 Ankyrin repeat Ank_4 PF13637.1 CCF47092.1 - 3.2e-38 129.4 5.7 6.6e-12 45.6 0.1 6.8 4 1 3 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF47092.1 - 4.1e-29 97.7 8.4 0.00021 21.2 0.0 9.7 11 0 0 11 11 11 6 Ankyrin repeat Ank_5 PF13857.1 CCF47092.1 - 1.2e-28 98.4 7.4 1.8e-07 31.1 0.6 7.6 1 1 6 7 7 7 6 Ankyrin repeats (many copies) MA3 PF02847.12 CCF47092.1 - 0.049 13.3 0.3 12 5.5 0.0 3.3 2 1 0 2 2 2 0 MA3 domain HTH_18 PF12833.2 CCF47092.1 - 0.086 12.9 0.0 0.25 11.4 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain ZZ PF00569.12 CCF47092.1 - 2.4 7.7 10.2 5.3 6.6 7.1 1.5 1 0 0 1 1 1 0 Zinc finger, ZZ type p450 PF00067.17 CCF47093.1 - 3.2e-62 210.5 0.0 5.4e-62 209.8 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 2OG-FeII_Oxy PF03171.15 CCF47094.1 - 5.4e-18 65.1 0.0 7.8e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 CCF47094.1 - 2.2e-17 63.6 0.0 3.4e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Gar1 PF04410.9 CCF47095.1 - 5.3e-25 87.6 0.1 6.7e-25 87.3 0.0 1.1 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region HAD_2 PF13419.1 CCF47096.1 - 3.4e-17 63.2 0.0 5.8e-17 62.4 0.0 1.4 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CCF47096.1 - 3.9e-09 36.0 0.0 7.2e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 CCF47096.1 - 9.8e-09 35.9 0.0 1.6e-07 32.0 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase NIF PF03031.13 CCF47096.1 - 0.00064 19.4 0.0 0.05 13.2 0.0 2.2 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase UDPG_MGDP_dh_C PF03720.10 CCF47096.1 - 0.029 14.5 0.0 0.074 13.2 0.0 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Hydrolase_6 PF13344.1 CCF47096.1 - 0.039 13.8 0.0 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF4473 PF14747.1 CCF47097.1 - 0.0065 16.6 0.1 0.0075 16.4 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4473) DUF1313 PF07011.6 CCF47097.1 - 0.053 13.1 0.0 0.059 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1313) Clusterin PF01093.12 CCF47097.1 - 0.1 11.3 0.1 0.11 11.2 0.1 1.0 1 0 0 1 1 1 0 Clusterin NADPH_Ox PF08414.5 CCF47097.1 - 0.14 12.2 0.1 0.26 11.4 0.0 1.4 2 0 0 2 2 2 0 Respiratory burst NADPH oxidase Pkinase PF00069.20 CCF47098.1 - 0.11 11.6 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain PAS_8 PF13188.1 CCF47099.1 - 0.016 15.0 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 PAS domain Snf7 PF03357.16 CCF47101.1 - 0.037 13.4 5.3 0.051 12.9 3.7 1.2 1 0 0 1 1 1 0 Snf7 DUF4090 PF13319.1 CCF47101.1 - 0.075 12.9 0.2 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4090) DUF1504 PF07399.6 CCF47101.1 - 0.1 11.2 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1504) SRP72 PF08492.7 CCF47104.1 - 8.7e-15 54.8 7.9 8.7e-15 54.8 5.5 2.5 2 0 0 2 2 2 1 SRP72 RNA-binding domain Apc3 PF12895.2 CCF47104.1 - 0.00057 19.9 10.7 0.0029 17.6 2.4 3.9 3 2 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 SPO22 PF08631.5 CCF47104.1 - 0.0036 16.4 0.2 0.038 13.0 0.0 2.6 3 0 0 3 3 3 1 Meiosis protein SPO22/ZIP4 like TPR_11 PF13414.1 CCF47104.1 - 0.072 12.7 9.2 3.1 7.5 0.1 4.3 3 1 0 3 3 3 0 TPR repeat TPR_2 PF07719.12 CCF47104.1 - 0.22 11.5 24.3 1.1 9.4 0.5 5.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_14 PF13428.1 CCF47104.1 - 0.74 10.6 25.2 7.1 7.5 0.0 7.5 6 1 3 9 9 9 0 Tetratricopeptide repeat TPR_1 PF00515.23 CCF47104.1 - 3.4 7.4 13.6 20 4.9 0.1 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.1 CCF47104.1 - 3.7 7.6 16.0 12 6.0 0.0 5.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_12 PF13424.1 CCF47104.1 - 6.1 6.8 23.3 0.24 11.3 0.3 5.8 5 2 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.1 CCF47104.1 - 7.7 7.2 8.4 38 5.0 0.1 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat PH_9 PF15410.1 CCF47105.1 - 0.0079 16.3 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 CCF47105.1 - 0.042 14.0 0.0 0.084 13.0 0.0 1.5 1 0 0 1 1 1 0 PH domain CBM_25 PF03423.8 CCF47106.1 - 0.13 12.3 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) MFS_1 PF07690.11 CCF47107.1 - 3.4e-29 101.6 34.1 5.1e-29 101.0 23.7 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CCF47107.1 - 1.2e-07 30.3 11.4 1.7e-07 29.8 7.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PAN_1 PF00024.21 CCF47108.1 - 3.2e-05 23.5 4.7 3.9e-05 23.3 3.2 1.3 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.1 CCF47108.1 - 0.024 14.3 1.7 0.024 14.3 1.2 2.0 1 1 0 2 2 2 0 PAN domain PAN_3 PF08277.7 CCF47108.1 - 0.04 13.5 0.2 0.062 12.9 0.1 1.3 1 0 0 1 1 1 0 PAN-like domain MANEC PF07502.9 CCF47108.1 - 0.045 13.7 0.6 0.059 13.3 0.4 1.4 1 0 0 1 1 1 0 MANEC domain Exo_endo_phos PF03372.18 CCF47111.1 - 6.7e-06 26.2 0.4 1.2e-05 25.3 0.3 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pkinase PF00069.20 CCF47112.1 - 2.4e-29 102.3 0.3 1.8e-23 83.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CCF47112.1 - 3.6e-12 45.8 0.0 1.1e-11 44.2 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF47112.1 - 0.066 12.1 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like FKBP_C PF00254.23 CCF47113.1 - 5.2e-31 106.5 0.2 3.1e-30 104.0 0.0 2.3 2 1 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase SET PF00856.23 CCF47113.1 - 0.93 9.7 5.2 2.3 8.5 0.6 2.2 2 0 0 2 2 2 0 SET domain DUF4066 PF13278.1 CCF47114.1 - 4e-13 48.9 0.0 5.5e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 Putative amidotransferase DJ-1_PfpI PF01965.19 CCF47114.1 - 0.001 18.5 0.0 0.0014 18.0 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family INTS5_N PF14837.1 CCF47115.1 - 0.017 14.5 0.0 0.017 14.5 0.0 1.0 1 0 0 1 1 1 0 Integrator complex subunit 5 N-terminus Asparaginase PF00710.15 CCF47116.1 - 5.1e-13 48.5 0.0 5.9e-13 48.3 0.0 1.0 1 0 0 1 1 1 1 Asparaginase NMO PF03060.10 CCF47116.1 - 0.092 11.8 0.1 0.11 11.5 0.1 1.1 1 0 0 1 1 1 0 Nitronate monooxygenase EBP PF05241.7 CCF47117.1 - 1.9e-65 219.5 7.7 2.2e-65 219.3 5.3 1.0 1 0 0 1 1 1 1 Emopamil binding protein Nic96 PF04097.9 CCF47118.1 - 5.5e-63 213.0 0.0 6.2e-63 212.9 0.0 1.0 1 0 0 1 1 1 1 Nup93/Nic96 Peptidase_M48 PF01435.13 CCF47119.1 - 4.2e-13 49.3 0.0 5.4e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M48 TPR_11 PF13414.1 CCF47121.1 - 1.7e-12 46.8 7.5 6.5e-06 25.7 0.0 4.5 6 0 0 6 6 6 2 TPR repeat TPR_2 PF07719.12 CCF47121.1 - 3.1e-12 45.4 7.0 0.00013 21.6 0.0 5.3 5 1 0 5 5 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 CCF47121.1 - 6.3e-11 41.4 3.0 0.0018 17.8 0.0 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.1 CCF47121.1 - 2.5e-07 31.1 16.1 0.038 14.6 1.3 5.3 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_12 PF13424.1 CCF47121.1 - 5.2e-07 29.5 1.5 0.034 14.0 0.2 4.2 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 CCF47121.1 - 9.4e-07 28.1 0.0 0.3 10.9 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 CCF47121.1 - 1.4e-05 24.9 1.6 3.7 7.9 0.0 6.3 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_4 PF07721.9 CCF47121.1 - 0.0004 20.5 19.4 0.058 13.8 2.2 5.1 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 CCF47121.1 - 0.00057 20.1 3.0 0.32 11.3 0.1 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 CCF47121.1 - 0.05 14.0 2.0 8.5 7.0 0.1 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.1 CCF47121.1 - 0.22 12.2 20.4 1.7 9.5 0.8 6.9 6 2 1 7 7 6 0 Tetratricopeptide repeat TPR_10 PF13374.1 CCF47121.1 - 4.2 7.4 7.0 46 4.1 0.3 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat SSF PF00474.12 CCF47122.1 - 2.4e-05 23.1 32.4 0.00041 19.1 22.4 2.2 1 1 0 1 1 1 1 Sodium:solute symporter family MadM PF03818.8 CCF47123.1 - 0.33 10.5 2.8 0.23 11.0 0.7 1.6 2 0 0 2 2 2 0 Malonate/sodium symporter MadM subunit RSN1_TM PF13967.1 CCF47126.1 - 3.4e-37 127.4 3.6 4e-37 127.1 2.5 1.0 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport FtsX PF02687.16 CCF47126.1 - 8.4 6.1 8.6 4.4 7.0 0.8 2.2 2 0 0 2 2 2 0 FtsX-like permease family RNA_pol_Rpb1_R PF05001.8 CCF47128.1 - 3 8.2 8.0 2.4 8.4 1.3 3.0 2 1 0 2 2 2 0 RNA polymerase Rpb1 C-terminal repeat PSRP-3_Ycf65 PF04839.8 CCF47129.1 - 0.041 13.9 0.2 0.23 11.5 0.0 1.9 2 0 0 2 2 2 0 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) Chorismate_bind PF00425.13 CCF47130.1 - 1.6e-88 296.4 0.0 1.9e-88 296.0 0.0 1.1 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.8 CCF47130.1 - 0.0013 18.7 2.0 2.4 8.1 0.3 3.5 3 1 0 3 3 3 2 Anthranilate synthase component I, N terminal region F-box PF00646.28 CCF47134.1 - 5.5e-09 35.4 0.5 1.5e-08 34.0 0.3 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 CCF47134.1 - 1.6e-06 27.7 2.7 2.7e-06 26.9 0.1 2.7 3 0 0 3 3 3 1 F-box-like Ycf1 PF05758.7 CCF47135.1 - 0.12 10.0 11.1 0.17 9.5 7.7 1.1 1 0 0 1 1 1 0 Ycf1 CAF-1_p150 PF11600.3 CCF47135.1 - 0.28 10.5 26.9 0.83 8.9 18.6 1.8 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Hid1 PF12722.2 CCF47135.1 - 0.88 7.1 19.2 1.2 6.6 13.3 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Otopetrin PF03189.8 CCF47135.1 - 4.2 6.2 5.8 6.1 5.7 4.0 1.2 1 0 0 1 1 1 0 Otopetrin V-ATPase_C PF03223.10 CCF47136.1 - 1.9e-119 398.8 0.1 2.1e-119 398.7 0.1 1.0 1 0 0 1 1 1 1 V-ATPase subunit C APS_kinase PF01583.15 CCF47137.1 - 6.3e-70 233.8 0.0 8.1e-70 233.5 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.1 CCF47137.1 - 2.9e-07 30.4 0.0 4.1e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CCF47137.1 - 3.8e-06 27.7 0.0 5.9e-06 27.1 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CCF47137.1 - 1.3e-05 25.5 0.0 2.3e-05 24.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 CCF47137.1 - 0.00026 20.3 0.0 0.00026 20.3 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_26 PF13500.1 CCF47137.1 - 0.0025 17.4 0.0 0.055 13.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain PRK PF00485.13 CCF47137.1 - 0.032 13.8 0.0 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_29 PF13555.1 CCF47137.1 - 0.092 12.2 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain Thymidylate_kin PF02223.12 CCF47137.1 - 0.11 11.9 0.1 6 6.1 0.0 2.2 1 1 1 2 2 2 0 Thymidylate kinase AAA_16 PF13191.1 CCF47137.1 - 0.12 12.3 0.5 0.45 10.4 0.3 1.8 1 1 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.7 CCF47137.1 - 0.12 11.4 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Trp_DMAT PF11991.3 CCF47138.1 - 2.8e-30 105.7 0.0 3.3e-30 105.5 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase CN_hydrolase PF00795.17 CCF47140.1 - 2.4e-22 79.1 0.0 3.4e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase MFS_1 PF07690.11 CCF47141.1 - 5.3e-11 41.8 19.9 3e-08 32.7 13.8 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF1469 PF07332.6 CCF47141.1 - 2.8 7.6 22.6 0.12 12.0 2.9 3.3 2 2 1 3 3 3 0 Protein of unknown function (DUF1469) Pyridoxal_deC PF00282.14 CCF47142.1 - 7.7e-43 146.3 0.0 8.5e-43 146.2 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Sulfate_tra_GLY PF13792.1 CCF47143.1 - 0.003 17.1 0.0 0.0049 16.5 0.0 1.3 1 0 0 1 1 1 1 Sulfate transporter N-terminal domain with GLY motif Ribosomal_L13e PF01294.13 CCF47143.1 - 0.049 13.1 0.0 0.068 12.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L13e VQ PF05678.9 CCF47143.1 - 0.13 11.3 0.1 0.27 10.3 0.0 1.5 1 0 0 1 1 1 0 VQ motif Stn1 PF10451.4 CCF47144.1 - 6.7e-05 21.8 0.0 7e-05 21.7 0.0 1.1 1 0 0 1 1 1 1 Telomere regulation protein Stn1 DnaJ PF00226.26 CCF47145.1 - 2e-24 85.1 2.7 6.3e-24 83.4 1.9 1.9 1 0 0 1 1 1 1 DnaJ domain DUF1635 PF07795.6 CCF47145.1 - 0.018 14.4 0.2 0.029 13.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) DUF493 PF04359.9 CCF47145.1 - 0.074 13.4 0.2 0.73 10.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF493) dCMP_cyt_deam_1 PF00383.17 CCF47146.1 - 5.9e-13 48.3 0.0 7.6e-13 47.9 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.6 CCF47146.1 - 0.009 15.6 0.0 0.011 15.3 0.0 1.1 1 0 0 1 1 1 1 APOBEC-like N-terminal domain Piwi PF02171.12 CCF47147.1 - 1.9e-70 237.2 0.0 3.1e-70 236.5 0.0 1.3 1 0 0 1 1 1 1 Piwi domain DUF1785 PF08699.5 CCF47147.1 - 1e-09 37.6 0.0 2.6e-09 36.2 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) PAZ PF02170.17 CCF47147.1 - 1.6e-06 27.4 0.0 3.3e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 PAZ domain Glyoxalase PF00903.20 CCF47148.1 - 2.5e-37 127.6 0.2 2.3e-18 66.4 0.0 2.6 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 CCF47148.1 - 9.5e-31 106.6 0.0 4.6e-14 52.9 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_4 PF13669.1 CCF47148.1 - 2.4e-17 62.8 0.0 1.2e-07 31.6 0.0 3.4 2 2 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.1 CCF47148.1 - 2.1e-08 34.2 0.0 0.00088 19.2 0.0 3.1 1 1 1 2 2 2 2 Glyoxalase-like domain CppA_N PF14506.1 CCF47148.1 - 0.0031 17.1 0.0 0.64 9.6 0.0 2.4 2 0 0 2 2 2 2 CppA N-terminal PRT_C PF08372.5 CCF47148.1 - 0.021 14.3 0.0 6.5 6.2 0.0 2.2 2 0 0 2 2 2 0 Plant phosphoribosyltransferase C-terminal EAP30 PF04157.11 CCF47148.1 - 0.077 12.1 0.0 4.2 6.4 0.0 2.2 2 0 0 2 2 2 0 EAP30/Vps36 family PP_M1 PF03012.9 CCF47148.1 - 0.1 11.9 0.1 4.8 6.4 0.0 2.1 2 0 0 2 2 2 0 Phosphoprotein PBD PF00786.23 CCF47150.1 - 9.7e-06 25.9 3.6 0.0042 17.4 0.2 2.5 2 0 0 2 2 2 2 P21-Rho-binding domain Pirin PF02678.11 CCF47152.1 - 7.8e-31 106.1 0.0 1.7e-30 105.0 0.0 1.6 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.8 CCF47152.1 - 3.4e-24 84.9 0.0 2e-23 82.4 0.0 1.9 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.6 CCF47152.1 - 1.4e-07 30.9 0.5 4.7e-05 22.8 0.2 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.7 CCF47152.1 - 0.0089 15.3 0.1 0.07 12.5 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF861) Stk19 PF10494.4 CCF47154.1 - 7.4e-64 215.5 0.0 8.9e-64 215.2 0.0 1.1 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 Sugar_tr PF00083.19 CCF47156.1 - 6.8e-32 110.6 17.3 8.6e-32 110.2 12.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF47156.1 - 5.4e-11 41.7 19.1 2.1e-10 39.8 13.8 1.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Romo1 PF10247.4 CCF47156.1 - 0.59 10.3 6.2 0.86 9.8 3.3 2.1 1 1 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 MFS_3 PF05977.8 CCF47156.1 - 2.7 6.0 8.4 3.5 5.6 5.8 1.2 1 0 0 1 1 1 0 Transmembrane secretion effector PAP2 PF01569.16 CCF47157.1 - 0.04 13.6 0.0 0.044 13.4 0.0 1.1 1 0 0 1 1 1 0 PAP2 superfamily ACPS PF01648.15 CCF47158.1 - 2.2e-05 24.2 0.0 2.6e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Fungal_trans PF04082.13 CCF47160.1 - 8.2e-06 24.8 1.9 1e-05 24.5 1.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF47162.1 - 7.6e-08 32.1 9.8 1.5e-07 31.1 6.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CCF47163.1 - 8.1e-14 51.0 0.0 1.3e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain NAD_synthase PF02540.12 CCF47164.1 - 2.6e-23 82.2 0.0 1.8e-22 79.4 0.0 2.1 1 1 0 1 1 1 1 NAD synthase Methyltransf_23 PF13489.1 CCF47165.1 - 4.2e-21 75.3 0.0 6.2e-21 74.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF47165.1 - 1.6e-10 41.5 0.0 8.8e-10 39.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF47165.1 - 9.6e-10 38.2 0.0 4.3e-09 36.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF47165.1 - 5.8e-08 33.1 0.0 1e-07 32.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF47165.1 - 2.5e-06 27.9 0.0 8.2e-06 26.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF47165.1 - 0.00047 20.4 0.0 0.0016 18.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF47165.1 - 0.015 14.3 0.0 0.032 13.2 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_26 PF13659.1 CCF47165.1 - 0.016 15.2 0.0 0.046 13.7 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 CCF47165.1 - 0.026 13.8 0.0 0.07 12.5 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain PrmA PF06325.8 CCF47165.1 - 0.067 12.3 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.4 CCF47165.1 - 0.14 11.5 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase PCMT PF01135.14 CCF47165.1 - 0.17 11.4 0.0 0.81 9.1 0.0 1.9 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.1 CCF47167.1 - 9.7e-22 77.3 0.0 1.7e-21 76.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF47167.1 - 1.5e-11 44.8 0.0 5.9e-11 42.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF47167.1 - 7.4e-10 38.6 0.0 1.7e-09 37.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF47167.1 - 3.2e-08 33.9 0.0 1.9e-07 31.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF47167.1 - 8.3e-08 32.6 0.0 2.6e-07 31.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF47167.1 - 7e-05 23.1 0.0 0.00018 21.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF47167.1 - 0.0039 16.3 0.0 0.65 9.0 0.0 2.6 2 1 1 3 3 3 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.14 CCF47167.1 - 0.0042 17.0 0.0 0.0064 16.5 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.12 CCF47167.1 - 0.015 14.3 0.0 0.046 12.7 0.0 1.8 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_2 PF00891.13 CCF47167.1 - 0.023 13.8 0.1 0.077 12.1 0.0 1.8 1 1 0 1 1 1 0 O-methyltransferase Methyltransf_26 PF13659.1 CCF47167.1 - 0.031 14.3 0.0 0.099 12.6 0.0 1.6 1 1 0 2 2 2 0 Methyltransferase domain CMAS PF02353.15 CCF47167.1 - 0.042 12.9 0.0 0.18 10.8 0.0 1.9 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase MTS PF05175.9 CCF47167.1 - 0.094 12.0 0.0 0.26 10.6 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain Slu7 PF11708.3 CCF47169.1 - 2.3e-75 253.4 21.4 2.3e-75 253.4 14.8 2.1 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.1 CCF47169.1 - 0.012 15.2 0.8 0.023 14.3 0.5 1.4 1 0 0 1 1 1 0 Zinc knuckle DNAJ_related PF12339.3 CCF47169.1 - 0.098 12.5 0.3 0.22 11.3 0.2 1.5 1 0 0 1 1 1 0 DNA-J related protein zf-CCHC PF00098.18 CCF47169.1 - 0.098 12.6 1.1 0.18 11.8 0.8 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.1 CCF47169.1 - 1.1 8.8 4.1 2.5 7.6 2.9 1.6 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger DUF3775 PF12616.3 CCF47169.1 - 2.4 8.0 6.0 1.3 8.8 0.1 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3775) Methyltransf_23 PF13489.1 CCF47171.1 - 6.1e-20 71.5 0.0 9.4e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF47171.1 - 6.4e-08 33.1 0.0 5.7e-07 30.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF47171.1 - 1e-07 31.6 0.0 9.8e-07 28.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF47171.1 - 4.3e-07 30.3 0.0 7e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF47171.1 - 3e-06 27.6 0.0 2.1e-05 24.9 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF47171.1 - 0.00019 21.7 0.0 0.00034 20.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 CCF47171.1 - 0.15 11.6 0.0 0.23 10.9 0.0 1.4 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.15 CCF47171.1 - 0.16 11.0 0.0 0.3 10.1 0.0 1.4 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase ABM PF03992.11 CCF47172.1 - 0.018 15.0 0.2 0.023 14.7 0.1 1.1 1 0 0 1 1 1 0 Antibiotic biosynthesis monooxygenase DUF3237 PF11578.3 CCF47173.1 - 2.2e-30 104.9 0.0 3.3e-30 104.3 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3237) Pectinesterase PF01095.14 CCF47174.1 - 2.4e-08 32.9 5.5 3.1e-08 32.5 3.8 1.1 1 0 0 1 1 1 1 Pectinesterase CENP-T PF15511.1 CCF47175.1 - 0.0014 17.9 7.7 0.0014 17.9 5.3 1.0 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T Daxx PF03344.10 CCF47175.1 - 0.22 9.9 22.6 0.28 9.6 15.7 1.0 1 0 0 1 1 1 0 Daxx Family SDA1 PF05285.7 CCF47175.1 - 1.8 7.7 19.8 2.3 7.4 13.7 1.1 1 0 0 1 1 1 0 SDA1 Pox_Ag35 PF03286.9 CCF47175.1 - 3.6 7.0 13.2 5.1 6.5 9.2 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Metallophos_2 PF12850.2 CCF47178.1 - 1.2e-05 25.2 0.0 1.3e-05 25.1 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 CCF47178.1 - 0.00036 19.9 0.0 0.00037 19.9 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF3425 PF11905.3 CCF47179.1 - 1e-16 61.0 1.9 9.8e-14 51.4 1.3 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF3425) FAM117 PF15388.1 CCF47180.1 - 0.97 8.6 9.0 1.3 8.1 6.3 1.2 1 0 0 1 1 1 0 Protein Family FAM117 SoxE PF06525.6 CCF47180.1 - 3.6 6.8 6.5 5.9 6.1 4.5 1.3 1 0 0 1 1 1 0 Sulfocyanin (SoxE) CAF-1_p150 PF11600.3 CCF47180.1 - 8.7 5.6 9.4 12 5.2 6.5 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Globin PF00042.17 CCF47182.1 - 0.00077 19.7 0.0 0.059 13.7 0.0 2.2 1 1 0 1 1 1 1 Globin Protoglobin PF11563.3 CCF47182.1 - 0.005 16.5 0.0 0.0068 16.0 0.0 1.2 1 0 0 1 1 1 1 Protoglobin Anth_synt_I_N PF04715.8 CCF47183.1 - 0.14 12.2 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 Anthranilate synthase component I, N terminal region Fungal_trans PF04082.13 CCF47185.1 - 3.9e-10 39.0 0.4 1.5e-09 37.1 0.3 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Pectate_lyase PF03211.8 CCF47186.1 - 6.7e-77 257.7 5.5 1.1e-76 257.0 3.8 1.2 1 0 0 1 1 1 1 Pectate lyase ChiC PF06483.6 CCF47188.1 - 0.04 13.6 0.0 0.049 13.3 0.0 1.1 1 0 0 1 1 1 0 Chitinase C Aminotran_3 PF00202.16 CCF47189.1 - 1e-96 323.7 0.0 1.2e-96 323.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 CCF47189.1 - 0.11 11.4 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II Voltage_CLC PF00654.15 CCF47191.1 - 3.7e-92 309.0 24.6 3.7e-92 309.0 17.0 1.9 2 0 0 2 2 2 1 Voltage gated chloride channel TAT_signal PF10518.4 CCF47191.1 - 0.013 15.4 3.4 0.013 15.4 2.4 3.1 3 0 0 3 3 3 0 TAT (twin-arginine translocation) pathway signal sequence NRDE-2 PF08424.5 CCF47193.1 - 3e-83 279.3 2.0 6.1e-82 275.0 0.5 2.9 3 0 0 3 3 3 1 NRDE-2, necessary for RNA interference TPR_14 PF13428.1 CCF47193.1 - 0.22 12.2 12.3 9.6 7.1 0.0 6.2 7 1 1 8 8 8 0 Tetratricopeptide repeat eIF-6 PF01912.13 CCF47194.1 - 4.1e-84 280.6 0.4 5.2e-84 280.2 0.2 1.1 1 0 0 1 1 1 1 eIF-6 family Methyltransf_2 PF00891.13 CCF47196.1 - 0.011 14.9 0.0 0.012 14.8 0.0 1.1 1 0 0 1 1 1 0 O-methyltransferase Pribosyltran PF00156.22 CCF47197.1 - 5e-10 39.1 0.3 3.7e-09 36.3 0.2 2.0 1 1 0 1 1 1 1 Phosphoribosyl transferase domain FAD_binding_3 PF01494.14 CCF47198.1 - 6.4e-12 45.1 0.0 7e-12 45.0 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 CCF47198.1 - 5.6e-06 26.2 0.2 1.6e-05 24.7 0.1 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CCF47198.1 - 1.5e-05 24.1 0.6 2.8e-05 23.2 0.4 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF47198.1 - 5.5e-05 23.1 0.1 8.3e-05 22.5 0.1 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CCF47198.1 - 5.7e-05 22.1 0.0 0.00061 18.7 0.0 2.1 2 1 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox PF00070.22 CCF47198.1 - 8.3e-05 22.9 0.0 0.00094 19.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF47198.1 - 0.00055 18.5 0.0 0.00076 18.0 0.0 1.1 1 0 0 1 1 1 1 HI0933-like protein 3HCDH_N PF02737.13 CCF47198.1 - 0.0018 17.9 0.0 0.0026 17.4 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.2 CCF47198.1 - 0.0021 17.1 0.2 0.011 14.9 0.2 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase DUF667 PF05018.8 CCF47198.1 - 0.014 14.6 0.0 0.02 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF667) FAD_binding_2 PF00890.19 CCF47198.1 - 0.015 14.1 0.1 0.056 12.2 0.0 1.8 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.12 CCF47198.1 - 0.035 13.2 0.1 0.055 12.5 0.0 1.2 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.16 CCF47198.1 - 0.053 13.0 0.0 0.095 12.2 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.1 CCF47198.1 - 0.095 12.9 0.0 0.15 12.3 0.0 1.4 1 1 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox_3 PF13738.1 CCF47198.1 - 0.15 12.1 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.16 CCF47198.1 - 0.15 11.8 0.1 0.35 10.6 0.1 1.5 1 0 0 1 1 1 0 ThiF family NAD_binding_8 PF13450.1 CCF47199.1 - 0.0022 17.9 3.2 0.0038 17.2 2.3 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain N2227 PF07942.7 CCF47199.1 - 0.03 13.2 0.0 0.041 12.8 0.0 1.2 1 0 0 1 1 1 0 N2227-like protein ThiF PF00899.16 CCF47199.1 - 0.15 11.8 0.4 0.23 11.2 0.3 1.3 1 0 0 1 1 1 0 ThiF family Pyr_redox_2 PF07992.9 CCF47199.1 - 0.29 10.9 1.6 0.46 10.3 1.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF47199.1 - 0.35 9.7 2.7 0.58 8.9 1.8 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase AMP-binding_C PF13193.1 CCF47201.1 - 0.0007 20.4 0.0 0.0012 19.8 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Protamine_P2 PF00841.14 CCF47202.1 - 1.1 9.7 8.8 1.3 9.6 6.1 1.1 1 0 0 1 1 1 0 Sperm histone P2 MFS_1 PF07690.11 CCF47204.1 - 6.2e-10 38.3 16.7 6.2e-10 38.3 11.6 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF47204.1 - 0.78 8.0 10.5 2.8 6.2 7.3 1.9 1 1 0 1 1 1 0 MFS/sugar transport protein HMG_box PF00505.14 CCF47205.1 - 2.6e-17 62.8 1.2 3.3e-17 62.4 0.1 1.7 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 CCF47205.1 - 9e-13 48.4 0.1 2.3e-12 47.1 0.1 1.7 1 0 0 1 1 1 1 HMG-box domain SAM_1 PF00536.25 CCF47205.1 - 2.3e-10 40.5 0.0 3.7e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 CCF47205.1 - 1.8e-07 30.9 0.0 3.2e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pneumo_att_G PF05539.6 CCF47205.1 - 0.081 12.2 5.1 0.15 11.4 3.5 1.4 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Adeno_E1B_55K_N PF04623.7 CCF47207.1 - 0.082 13.4 3.5 0.16 12.4 2.4 1.4 1 0 0 1 1 1 0 Adenovirus E1B protein N-terminus DUF418 PF04235.7 CCF47208.1 - 0.091 12.4 0.3 0.099 12.3 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF418) DUF3929 PF13066.1 CCF47208.1 - 0.093 12.5 0.1 0.12 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3929) TPP_enzyme_N PF02776.13 CCF47209.1 - 2.3e-36 124.8 0.3 2.7e-36 124.6 0.2 1.0 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain POR_N PF01855.14 CCF47209.1 - 0.1 12.0 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg AAL_decarboxy PF03306.8 CCF47210.1 - 3.4e-27 94.9 0.0 3.7e-27 94.8 0.0 1.0 1 0 0 1 1 1 1 Alpha-acetolactate decarboxylase P33MONOX PF15302.1 CCF47211.1 - 0.045 13.3 2.0 0.092 12.3 0.3 1.9 1 1 1 2 2 2 0 P33 mono-oxygenase DUF3622 PF12286.3 CCF47211.1 - 1.3 9.3 6.8 2.8 8.3 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3622) adh_short PF00106.20 CCF47212.1 - 0.017 15.0 0.4 0.019 14.8 0.3 1.1 1 0 0 1 1 1 0 short chain dehydrogenase DEAD PF00270.24 CCF47213.1 - 6e-47 159.2 0.0 1.9e-45 154.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CCF47213.1 - 5e-28 96.7 0.1 1.3e-27 95.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CCF47213.1 - 0.0047 16.7 0.0 0.012 15.4 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.1 CCF47213.1 - 0.025 13.6 0.1 0.046 12.7 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF1253 PF06862.7 CCF47213.1 - 0.064 11.6 0.0 0.21 9.9 0.0 1.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1253) CHCH PF06747.8 CCF47214.1 - 0.0056 16.5 7.7 0.01 15.7 5.3 1.5 1 0 0 1 1 1 1 CHCH domain COX17 PF05051.8 CCF47214.1 - 0.016 15.2 2.1 0.022 14.7 1.5 1.2 1 0 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.5 CCF47214.1 - 0.052 13.3 4.2 0.18 11.6 2.9 1.8 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like DUF2948 PF11164.3 CCF47214.1 - 0.069 12.7 0.4 0.078 12.6 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2948) Phage_B PF02304.10 CCF47214.1 - 0.13 12.5 1.0 0.15 12.3 0.7 1.1 1 0 0 1 1 1 0 Scaffold protein B DUF3295 PF11702.3 CCF47214.1 - 0.29 10.0 2.0 0.29 10.0 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) QueT PF06177.6 CCF47215.1 - 0.00026 21.0 0.8 0.00034 20.6 0.6 1.2 1 0 0 1 1 1 1 QueT transporter NfeD PF01957.13 CCF47215.1 - 0.065 13.3 1.8 1.6 8.9 0.4 2.1 1 1 1 2 2 2 0 NfeD-like C-terminal, partner-binding UPF0060 PF02694.10 CCF47215.1 - 0.47 10.4 4.4 0.52 10.3 1.7 1.9 1 1 1 2 2 2 0 Uncharacterised BCR, YnfA/UPF0060 family PEP_mutase PF13714.1 CCF47216.1 - 2.8e-53 180.5 0.3 3.6e-53 180.2 0.2 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.16 CCF47216.1 - 7.3e-13 47.5 0.0 3e-12 45.5 0.0 1.8 1 1 1 2 2 2 1 Isocitrate lyase family Pantoate_transf PF02548.10 CCF47216.1 - 0.0014 17.8 0.1 0.022 13.8 0.0 2.0 2 0 0 2 2 2 1 Ketopantoate hydroxymethyltransferase Fis1_TPR_C PF14853.1 CCF47218.1 - 1.8e-25 88.5 2.4 3.6e-25 87.5 1.6 1.5 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.1 CCF47218.1 - 2.8e-17 61.6 0.0 4.6e-17 61.0 0.0 1.4 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_16 PF13432.1 CCF47218.1 - 0.0014 19.2 0.4 0.0027 18.3 0.3 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 CCF47218.1 - 0.0019 17.9 2.0 0.0036 17.1 1.4 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.1 CCF47218.1 - 0.15 12.5 1.1 0.22 12.0 0.2 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat FAD_binding_3 PF01494.14 CCF47219.1 - 0.0061 15.6 0.0 0.0082 15.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain BLVR PF06375.6 CCF47219.1 - 1.1 9.1 6.8 1.6 8.5 4.7 1.2 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) Calsarcin PF05556.6 CCF47221.1 - 0.014 14.6 0.2 0.017 14.3 0.1 1.1 1 0 0 1 1 1 0 Calcineurin-binding protein (Calsarcin) Ldh_1_N PF00056.18 CCF47222.1 - 4.5e-44 149.6 0.1 5.9e-44 149.3 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 CCF47222.1 - 7.2e-33 113.7 0.0 1.2e-32 113.0 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.14 CCF47222.1 - 0.00076 18.2 0.0 0.001 17.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.11 CCF47222.1 - 0.16 11.2 0.2 11 5.2 0.0 2.2 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase RCR PF12273.3 CCF47224.1 - 3.3e-10 40.6 2.2 4.5e-10 40.1 1.5 1.1 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red Tubulin_3 PF14881.1 CCF47225.1 - 3.4e-78 261.2 0.1 5.4e-78 260.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.4 CCF47225.1 - 4.5e-41 139.5 0.0 7.6e-41 138.7 0.0 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.20 CCF47225.1 - 1.9e-10 40.9 0.0 2.1e-06 27.7 0.0 2.3 2 0 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain PAP_central PF04928.12 CCF47226.1 - 4.7e-102 340.1 0.0 7e-102 339.5 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.10 CCF47226.1 - 1.5e-46 157.8 0.2 3.1e-46 156.7 0.1 1.6 2 0 0 2 2 2 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.18 CCF47226.1 - 1.8e-08 34.5 0.0 3.8e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain HET PF06985.6 CCF47229.1 - 0.067 13.3 1.5 0.069 13.3 0.5 1.5 2 0 0 2 2 2 0 Heterokaryon incompatibility protein (HET) Homeobox PF00046.24 CCF47230.1 - 3.9e-13 48.7 3.5 7.4e-13 47.9 2.4 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 CCF47230.1 - 0.0043 16.7 0.6 0.013 15.1 0.4 1.8 1 0 0 1 1 1 1 Homeobox KN domain ADIP PF11559.3 CCF47230.1 - 0.24 11.2 9.2 0.5 10.2 6.4 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding OmpH PF03938.9 CCF47230.1 - 0.92 9.4 8.2 1.5 8.7 5.7 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Alpha-amylase PF00128.19 CCF47232.1 - 9.9e-48 163.1 0.7 1.2e-47 162.8 0.5 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.1 CCF47232.1 - 0.026 13.4 0.0 0.031 13.1 0.0 1.1 1 0 0 1 1 1 0 glucanotransferase domain of human glycogen debranching enzyme DUF2450 PF10475.4 CCF47232.1 - 0.036 12.9 0.0 0.044 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) Tim17 PF02466.14 CCF47233.1 - 4.1e-05 23.6 2.7 7.3e-05 22.8 1.6 1.6 1 1 1 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family Metallophos PF00149.23 CCF47235.1 - 4.2e-09 36.1 3.7 1.2e-08 34.5 2.3 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase NIF PF03031.13 CCF47236.1 - 1.6e-36 125.3 0.0 2.3e-36 124.8 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase NmrA PF05368.8 CCF47237.1 - 8.3e-10 38.3 0.0 1.1e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Hypoth_Ymh PF09509.5 CCF47238.1 - 0.072 12.7 0.2 0.18 11.4 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (Hypoth_ymh) CBM_1 PF00734.13 CCF47239.1 - 6.4e-15 54.5 11.2 6.4e-15 54.5 7.8 1.9 2 0 0 2 2 2 1 Fungal cellulose binding domain COX1 PF00115.15 CCF47240.1 - 0.0086 14.7 1.5 0.011 14.4 1.0 1.1 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I DUF4117 PF13491.1 CCF47240.1 - 0.02 14.3 0.3 0.024 14.0 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4117) Corona_S2 PF01601.11 CCF47240.1 - 0.025 12.7 0.1 0.032 12.3 0.1 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein FA_desaturase PF00487.19 CCF47240.1 - 0.061 12.7 2.7 0.1 12.0 1.9 1.3 1 0 0 1 1 1 0 Fatty acid desaturase Tetraspannin PF00335.15 CCF47240.1 - 0.076 12.2 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 Tetraspanin family DUF1673 PF07895.6 CCF47240.1 - 0.083 12.4 0.0 0.099 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) PQ-loop PF04193.9 CCF47240.1 - 6.2 6.4 6.8 4.2 6.9 0.1 2.5 3 0 0 3 3 3 0 PQ loop repeat FixP_N PF14715.1 CCF47240.1 - 7.4 6.0 7.7 5.9 6.3 1.1 2.2 2 0 0 2 2 2 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Ribosomal_L33 PF00471.15 CCF47241.1 - 2.6e-06 27.5 0.0 3.5e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L33 DUF2371 PF10177.4 CCF47244.1 - 0.019 14.8 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) DUF4448 PF14610.1 CCF47244.1 - 0.11 11.9 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) NUC153 PF08159.7 CCF47245.1 - 1.5e-12 46.8 2.2 3e-12 45.9 1.5 1.5 1 0 0 1 1 1 1 NUC153 domain BTB_2 PF02214.17 CCF47246.1 - 6.2e-07 29.5 0.1 0.002 18.2 0.0 2.3 2 0 0 2 2 2 2 BTB/POZ domain TRAM_LAG1_CLN8 PF03798.11 CCF47247.1 - 1.8e-38 132.0 13.9 1.8e-38 132.0 9.6 1.8 3 0 0 3 3 3 1 TLC domain TRAM1 PF08390.6 CCF47247.1 - 5.5e-18 64.2 0.0 1.6e-17 62.7 0.0 1.9 1 0 0 1 1 1 1 TRAM1-like protein Peptidase_C37 PF05416.7 CCF47248.1 - 2.1 6.5 6.6 2.4 6.3 4.6 1.2 1 0 0 1 1 1 0 Southampton virus-type processing peptidase P33MONOX PF15302.1 CCF47249.1 - 0.045 13.3 2.0 0.092 12.3 0.3 1.9 1 1 1 2 2 2 0 P33 mono-oxygenase DUF3622 PF12286.3 CCF47249.1 - 1.3 9.3 6.8 2.8 8.3 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3622) Esterase_phd PF10503.4 CCF47251.1 - 2.7e-13 49.6 0.0 3.1e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.16 CCF47251.1 - 0.00043 19.5 0.1 0.00069 18.8 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CCF47251.1 - 0.00056 19.6 0.1 0.00076 19.2 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF47251.1 - 0.0052 16.6 0.1 0.0072 16.2 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family COesterase PF00135.23 CCF47251.1 - 0.0056 15.4 0.0 0.0075 15.0 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF47251.1 - 0.016 14.7 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 CCF47251.1 - 0.017 14.5 0.0 2.3 7.5 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Eno-Rase_NADH_b PF12242.3 CCF47251.1 - 0.1 12.4 0.5 0.46 10.3 0.2 2.1 2 1 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Abhydrolase_1 PF00561.15 CCF47251.1 - 0.11 12.0 0.0 0.14 11.6 0.0 1.4 1 1 0 1 1 1 0 alpha/beta hydrolase fold PHP PF02811.14 CCF47252.1 - 2.2e-08 34.0 0.1 2.8e-08 33.7 0.1 1.1 1 0 0 1 1 1 1 PHP domain Transposase_22 PF02994.9 CCF47255.1 - 0.0063 15.0 1.4 0.0063 15.0 0.9 1.0 1 0 0 1 1 1 1 L1 transposable element Use1 PF09753.4 CCF47255.1 - 0.0064 15.9 0.3 0.007 15.8 0.2 1.0 1 0 0 1 1 1 1 Membrane fusion protein Use1 Tup_N PF08581.5 CCF47255.1 - 0.01 16.0 2.2 0.013 15.6 1.6 1.2 1 0 0 1 1 1 0 Tup N-terminal FlaC_arch PF05377.6 CCF47255.1 - 0.02 14.7 0.4 0.026 14.3 0.3 1.3 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) SAS4 PF15460.1 CCF47255.1 - 0.026 14.4 0.5 0.033 14.0 0.4 1.2 1 0 0 1 1 1 0 Something about silencing, SAS, complex subunit 4 ApoLp-III PF07464.6 CCF47255.1 - 0.042 13.8 1.2 0.045 13.7 0.8 1.1 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) DUF948 PF06103.6 CCF47255.1 - 0.044 13.6 0.1 0.048 13.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Fmp27_WPPW PF10359.4 CCF47255.1 - 0.049 12.0 0.6 0.048 12.0 0.4 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain AAA_32 PF13654.1 CCF47255.1 - 0.052 12.2 0.4 0.05 12.2 0.3 1.0 1 0 0 1 1 1 0 AAA domain Endotoxin_N PF03945.9 CCF47255.1 - 0.06 12.7 0.1 0.063 12.6 0.1 1.1 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain Prefoldin_2 PF01920.15 CCF47255.1 - 0.11 12.2 4.4 0.14 11.9 3.0 1.1 1 0 0 1 1 1 0 Prefoldin subunit DUF725 PF05267.7 CCF47255.1 - 0.12 12.2 0.1 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF725) DUF4337 PF14235.1 CCF47255.1 - 0.28 11.0 1.8 0.27 11.0 1.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Tom5 PF10642.4 CCF47256.1 - 9.2e-20 70.0 1.1 9.6e-20 69.9 0.8 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase GDC-P PF02347.11 CCF47257.1 - 1.3e-171 571.0 0.0 2.1e-158 527.5 0.0 2.7 2 1 0 2 2 2 2 Glycine cleavage system P-protein Aminotran_5 PF00266.14 CCF47257.1 - 6.5e-10 38.2 0.0 5.4e-05 22.0 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class-V Beta_elim_lyase PF01212.16 CCF47257.1 - 7.1e-05 22.0 0.0 0.00012 21.3 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 CCF47257.1 - 0.015 13.5 0.0 0.027 12.7 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Thioredox_DsbH PF03190.10 CCF47258.1 - 7.9e-57 191.5 0.0 1.2e-56 190.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.1 CCF47258.1 - 2.9e-05 24.0 0.0 6.8e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like Robl_LC7 PF03259.12 CCF47258.1 - 0.067 12.7 0.4 0.22 11.1 0.2 1.8 2 0 0 2 2 2 0 Roadblock/LC7 domain Sigma70_r4 PF04545.11 CCF47258.1 - 0.085 12.1 0.2 0.19 11.0 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 Neugrin PF06413.6 CCF47260.1 - 1.2e-13 51.4 0.5 1.7e-13 50.9 0.2 1.3 1 1 0 1 1 1 1 Neugrin MRP-L20 PF12824.2 CCF47260.1 - 6.2e-08 32.7 0.1 6.2e-08 32.7 0.1 1.9 2 0 0 2 2 2 1 Mitochondrial ribosomal protein subunit L20 HTH_29 PF13551.1 CCF47260.1 - 0.0005 20.2 3.7 0.0025 17.9 0.0 2.5 2 2 0 2 2 2 1 Winged helix-turn helix Sigma70_r4 PF04545.11 CCF47260.1 - 0.0082 15.4 0.1 0.064 12.5 0.0 2.3 2 0 0 2 2 2 1 Sigma-70, region 4 HEAT_2 PF13646.1 CCF47261.1 - 2.3e-05 24.6 0.2 2.5e-05 24.4 0.1 1.0 1 0 0 1 1 1 1 HEAT repeats IBN_N PF03810.14 CCF47261.1 - 2.9e-05 23.8 0.0 3.7e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain DUF3385 PF11865.3 CCF47261.1 - 0.033 14.1 0.0 0.045 13.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3385) Toxin_7 PF05980.7 CCF47263.1 - 0.0058 16.6 1.8 0.013 15.5 1.2 1.6 1 0 0 1 1 1 1 Toxin 7 Tachystatin_A PF11406.3 CCF47263.1 - 0.0089 15.8 4.0 0.011 15.6 2.8 1.3 1 0 0 1 1 1 1 Antimicrobial peptide tachystatin A Toxin_12 PF07740.7 CCF47263.1 - 0.087 13.3 0.5 0.087 13.3 0.4 1.6 2 0 0 2 2 2 0 Ion channel inhibitory toxin Conotoxin PF02950.12 CCF47263.1 - 0.16 12.7 0.8 0.16 12.7 0.6 1.1 1 0 0 1 1 1 0 Conotoxin DUF3712 PF12505.3 CCF47264.1 - 2.3e-08 34.1 0.1 1.6e-05 24.9 0.1 2.9 2 0 0 2 2 2 2 Protein of unknown function (DUF3712) OTCace_N PF02729.16 CCF47265.1 - 1.9e-41 141.0 0.0 2.7e-41 140.5 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.19 CCF47265.1 - 1.7e-39 135.1 0.0 7.3e-39 133.1 0.0 1.8 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Gp_dh_N PF00044.19 CCF47265.1 - 0.0081 16.1 0.0 0.79 9.6 0.0 2.3 2 0 0 2 2 2 2 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain ALS_ss_C PF10369.4 CCF47266.1 - 2.3e-19 68.8 0.0 3.8e-18 64.9 0.0 2.4 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.20 CCF47266.1 - 7e-13 47.7 0.1 1.4e-12 46.7 0.1 1.6 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.1 CCF47266.1 - 4.6e-10 39.1 0.0 8.4e-10 38.3 0.0 1.5 1 0 0 1 1 1 1 ACT domain KH_1 PF00013.24 CCF47267.1 - 1.4e-08 34.2 0.0 9.8e-05 21.9 0.0 2.5 2 0 0 2 2 2 2 KH domain KH_3 PF13014.1 CCF47267.1 - 2.1e-07 30.4 0.6 0.00012 21.6 0.0 3.1 4 0 0 4 4 4 2 KH domain Trp_repressor PF01371.14 CCF47267.1 - 0.11 12.3 0.1 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 Trp repressor protein FA_desaturase PF00487.19 CCF47268.1 - 2.9e-30 105.5 18.0 3.7e-30 105.2 12.4 1.1 1 0 0 1 1 1 1 Fatty acid desaturase PGI PF00342.14 CCF47269.1 - 2.2e-119 399.0 0.4 2.5e-119 398.8 0.3 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Methyltransf_23 PF13489.1 CCF47271.1 - 7.8e-16 58.2 0.0 1.1e-15 57.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF47271.1 - 9.1e-16 58.1 0.0 1.7e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF47271.1 - 3.1e-14 52.8 0.0 3.2e-13 49.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 CCF47271.1 - 6.7e-14 51.6 0.2 4.6e-12 45.5 0.1 2.2 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.7 CCF47271.1 - 2e-13 50.6 0.0 3.7e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF47271.1 - 4.7e-11 43.2 0.0 1.2e-10 41.9 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF47271.1 - 6.2e-09 36.1 0.0 1.4e-08 34.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF47271.1 - 3.6e-06 26.2 0.0 9.5e-06 24.8 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 CCF47271.1 - 7.4e-06 25.9 0.0 1.8e-05 24.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 CCF47271.1 - 0.00021 20.7 0.0 0.004 16.5 0.1 2.1 1 1 1 2 2 2 1 Methionine biosynthesis protein MetW DOT1 PF08123.8 CCF47271.1 - 0.0013 18.1 0.0 0.0019 17.5 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 MTS PF05175.9 CCF47271.1 - 0.004 16.5 0.2 0.013 14.9 0.1 1.8 2 0 0 2 2 2 1 Methyltransferase small domain PCMT PF01135.14 CCF47271.1 - 0.005 16.3 0.0 0.0077 15.7 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.1 CCF47271.1 - 0.013 15.1 0.1 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.9 CCF47271.1 - 0.014 14.5 0.0 0.022 13.9 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB FtsJ PF01728.14 CCF47271.1 - 0.014 15.3 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_PK PF05891.7 CCF47271.1 - 0.05 12.8 0.0 0.38 10.0 0.0 2.0 1 1 0 1 1 1 0 AdoMet dependent proline di-methyltransferase RrnaAD PF00398.15 CCF47271.1 - 0.071 12.1 0.1 0.1 11.6 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase V-ATPase_H_C PF11698.3 CCF47271.1 - 0.072 13.0 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 V-ATPase subunit H NodS PF05401.6 CCF47271.1 - 0.1 11.9 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Proteasome PF00227.21 CCF47272.1 - 5.4e-29 100.8 0.0 6.4e-29 100.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF3738 PF12543.3 CCF47272.1 - 0.15 11.6 0.1 7 6.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3738) p450 PF00067.17 CCF47273.1 - 1.6e-60 204.9 0.0 2.1e-60 204.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_3 PF01494.14 CCF47275.1 - 1.6e-16 60.3 3.8 2.8e-16 59.5 1.2 2.3 1 1 1 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.1 CCF47275.1 - 6e-08 32.6 0.2 1.5e-07 31.3 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CCF47275.1 - 1.3e-05 24.2 2.0 0.00017 20.5 1.1 2.2 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.19 CCF47275.1 - 6.5e-05 22.0 1.3 6.5e-05 22.0 0.9 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CCF47275.1 - 0.00011 22.1 0.0 0.00017 21.5 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CCF47275.1 - 0.00036 19.1 0.1 0.00058 18.4 0.1 1.4 1 1 0 1 1 1 1 HI0933-like protein AlaDh_PNT_C PF01262.16 CCF47275.1 - 0.00067 19.2 0.0 0.001 18.6 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.12 CCF47275.1 - 0.0025 16.9 0.1 0.0046 16.0 0.0 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.1 CCF47275.1 - 0.0038 16.9 0.5 0.018 14.7 0.2 2.5 2 1 0 2 2 2 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.7 CCF47275.1 - 0.005 15.8 1.9 0.029 13.2 0.1 2.5 2 1 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_3 PF13738.1 CCF47275.1 - 0.0062 16.6 0.4 0.012 15.7 0.0 1.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF47275.1 - 0.0089 16.4 0.2 0.033 14.6 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CCF47275.1 - 0.0096 14.8 0.2 0.014 14.2 0.2 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A 3HCDH_N PF02737.13 CCF47275.1 - 0.15 11.7 0.1 0.15 11.7 0.1 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain RVP PF00077.15 CCF47276.1 - 0.42 10.5 2.2 0.63 9.9 0.0 2.1 2 0 0 2 2 2 0 Retroviral aspartyl protease DUF702 PF05142.7 CCF47276.1 - 1.7 8.7 11.5 1.7 8.7 3.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Macoilin PF09726.4 CCF47276.1 - 2.3 6.4 13.2 2.4 6.3 9.1 1.0 1 0 0 1 1 1 0 Transmembrane protein TFIIA PF03153.8 CCF47276.1 - 4.9 6.9 30.1 5.5 6.7 20.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NST1 PF13945.1 CCF47276.1 - 7.7 6.5 16.1 1.2 9.1 3.9 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator EPL1 PF10513.4 CCF47276.1 - 9.6 6.4 16.6 0.31 11.2 1.5 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like Fibrillarin PF01269.12 CCF47277.1 - 3.2e-48 163.6 0.1 3.5e-48 163.5 0.1 1.0 1 0 0 1 1 1 1 Fibrillarin DUF3982 PF13138.1 CCF47277.1 - 0.092 12.6 0.1 0.38 10.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3982) GCD14 PF08704.5 CCF47277.1 - 0.11 11.9 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Paramyxo_PCT PF14320.1 CCF47279.1 - 0.14 11.0 0.0 0.2 10.4 0.0 1.2 1 0 0 1 1 1 0 Phosphoprotein P region PCT disordered SBDS PF01172.13 CCF47281.1 - 3.9e-25 87.4 1.2 4.6e-25 87.2 0.8 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein CorA PF01544.13 CCF47281.1 - 0.077 12.0 0.1 0.088 11.8 0.0 1.0 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF2200 PF09966.4 CCF47282.1 - 0.067 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2200) Tubulin PF00091.20 CCF47283.1 - 0.37 10.5 2.3 0.64 9.8 0.3 1.8 1 1 1 2 2 2 0 Tubulin/FtsZ family, GTPase domain MFS_1 PF07690.11 CCF47284.1 - 2.9e-36 124.8 20.5 1.9e-28 99.1 1.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF47284.1 - 3.1e-09 35.9 12.7 8.6e-09 34.4 3.4 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_2 PF13347.1 CCF47284.1 - 0.00055 18.4 3.8 0.00055 18.4 2.6 3.1 2 1 1 3 3 3 2 MFS/sugar transport protein Inositol_P PF00459.20 CCF47285.1 - 4.9e-19 68.6 3.1 5.4e-19 68.5 2.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family DUF1034 PF06280.7 CCF47286.1 - 4.6e-06 27.0 0.0 1.1e-05 25.7 0.0 1.6 1 1 0 1 1 1 1 Fn3-like domain (DUF1034) Peptidase_S8 PF00082.17 CCF47286.1 - 0.015 14.4 0.2 0.021 14.0 0.1 1.2 1 0 0 1 1 1 0 Subtilase family Pam16 PF03656.8 CCF47286.1 - 0.024 14.4 0.0 0.032 14.0 0.0 1.1 1 0 0 1 1 1 0 Pam16 DUF4232 PF14016.1 CCF47286.1 - 0.059 13.0 0.0 0.67 9.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4232) ELO PF01151.13 CCF47287.1 - 2.8e-55 187.3 9.4 3.4e-55 187.0 6.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family PFK PF00365.15 CCF47291.1 - 1.4e-148 493.4 0.8 2.8e-119 397.2 1.4 2.1 2 0 0 2 2 2 2 Phosphofructokinase UVR PF02151.14 CCF47291.1 - 0.0048 16.3 0.4 0.011 15.1 0.3 1.6 1 0 0 1 1 1 1 UvrB/uvrC motif Med17 PF10156.4 CCF47292.1 - 4.5e-78 262.5 0.0 5.8e-78 262.2 0.0 1.1 1 0 0 1 1 1 1 Subunit 17 of Mediator complex SNF2_N PF00176.18 CCF47293.1 - 3.6e-18 65.3 0.0 6.4e-18 64.5 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CCF47293.1 - 6e-11 42.0 0.0 1.4e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.1 CCF47293.1 - 2.9e-08 33.3 4.9 6e-08 32.3 3.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 CCF47293.1 - 3.2e-08 33.0 5.1 6.8e-08 32.0 3.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CCF47293.1 - 6.3e-07 29.3 5.0 1.4e-06 28.2 3.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF47293.1 - 2e-06 27.3 3.3 3.7e-06 26.4 2.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CCF47293.1 - 1.7e-05 24.5 5.7 4.7e-05 23.1 3.9 1.8 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 CCF47293.1 - 6.8e-05 22.5 4.2 0.00015 21.4 2.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 CCF47293.1 - 9.6e-05 22.0 2.2 0.00021 20.9 1.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Nop14 PF04147.7 CCF47293.1 - 0.0093 13.9 4.6 0.014 13.3 3.2 1.3 1 0 0 1 1 1 1 Nop14-like family YL1 PF05764.8 CCF47293.1 - 0.3 10.6 11.9 0.64 9.5 8.2 1.5 1 0 0 1 1 1 0 YL1 nuclear protein SDA1 PF05285.7 CCF47293.1 - 0.48 9.6 16.2 0.04 13.2 7.9 1.5 2 0 0 2 2 2 0 SDA1 zf-RING_4 PF14570.1 CCF47293.1 - 0.75 9.4 5.2 2.8 7.6 3.7 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Pkinase PF00069.20 CCF47294.1 - 9e-76 254.4 0.0 1.9e-37 128.8 0.0 4.3 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 CCF47294.1 - 8.4e-51 172.5 0.0 7.7e-22 77.5 0.0 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.17 CCF47294.1 - 3.3e-12 46.2 0.0 1.1e-11 44.6 0.0 1.9 1 0 0 1 1 1 1 RWD domain tRNA-synt_His PF13393.1 CCF47294.1 - 3.1e-09 36.3 1.2 9.5e-09 34.7 0.0 2.3 2 1 0 2 2 2 1 Histidyl-tRNA synthetase APH PF01636.18 CCF47294.1 - 1.4e-05 24.9 3.8 0.081 12.6 0.2 3.0 3 0 0 3 3 3 2 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 CCF47294.1 - 0.05 12.9 0.0 0.9 8.8 0.0 2.3 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL NOA36 PF06524.7 CCF47294.1 - 6.9 5.8 11.4 14 4.8 7.9 1.5 1 0 0 1 1 1 0 NOA36 protein Cut12 PF11500.3 CCF47295.1 - 3.2e-44 150.2 19.2 3.2e-44 150.2 13.3 4.6 2 1 2 4 4 4 1 Spindle pole body formation-associated protein Rad50_zn_hook PF04423.9 CCF47295.1 - 6 6.4 14.2 2.5 7.6 0.3 3.6 3 0 0 3 3 3 0 Rad50 zinc hook motif IGPD PF00475.13 CCF47296.1 - 1.1e-59 200.4 0.2 1.5e-59 200.0 0.1 1.2 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase ArgJ PF01960.13 CCF47297.1 - 4.6e-145 482.8 0.1 5.2e-145 482.7 0.1 1.0 1 0 0 1 1 1 1 ArgJ family DER1 PF04511.10 CCF47298.1 - 1.6e-25 89.8 6.9 1.8e-25 89.5 4.8 1.0 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.17 CCF47298.1 - 0.56 10.2 7.7 0.081 12.9 2.6 1.7 2 0 0 2 2 2 0 Rhomboid family DUF3499 PF12005.3 CCF47299.1 - 0.0053 16.9 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3499) IncA PF04156.9 CCF47299.1 - 0.13 11.8 0.0 0.25 10.9 0.0 1.4 1 1 0 1 1 1 0 IncA protein SPC12 PF06645.8 CCF47302.1 - 3.3e-29 100.5 0.0 4e-29 100.2 0.0 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) zf-rbx1 PF12678.2 CCF47303.1 - 3.8e-35 119.8 13.5 4.9e-35 119.4 9.4 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 CCF47303.1 - 3.9e-17 61.8 9.8 5.1e-17 61.5 6.8 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.1 CCF47303.1 - 4.7e-07 29.5 11.8 3.1e-06 26.9 8.2 2.0 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 CCF47303.1 - 0.0013 18.3 11.5 0.023 14.3 8.0 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF47303.1 - 0.0035 16.9 9.8 0.43 10.2 7.0 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CCF47303.1 - 0.048 13.6 12.5 0.052 13.5 5.4 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CCF47303.1 - 0.45 10.2 11.6 4.3 7.1 8.0 2.4 1 1 1 2 2 2 0 zinc-RING finger domain FANCL_C PF11793.3 CCF47303.1 - 0.85 9.6 9.4 4.8 7.2 6.6 2.0 1 1 1 2 2 2 0 FANCL C-terminal domain zf-HC5HC2H_2 PF13832.1 CCF47303.1 - 0.88 9.5 9.8 2.7 8.0 6.8 1.8 1 1 0 1 1 1 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 CCF47303.1 - 1.1 9.4 10.5 0.99 9.5 0.9 2.2 1 1 1 2 2 2 0 PHD-like zinc-binding domain zf-RING_UBOX PF13445.1 CCF47303.1 - 1.7 8.4 7.0 4 7.2 2.4 2.3 1 1 1 2 2 2 0 RING-type zinc-finger DUF3328 PF11807.3 CCF47305.1 - 4.7e-07 29.7 0.1 4.7e-07 29.7 0.0 1.2 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) G-alpha PF00503.15 CCF47307.1 - 8.3e-115 383.5 1.9 9.4e-115 383.3 1.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 CCF47307.1 - 7.6e-11 41.5 0.2 1.9e-10 40.2 0.2 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family zf-CHC2 PF01807.15 CCF47307.1 - 6.8e-05 22.3 0.0 0.00032 20.2 0.0 2.0 2 0 0 2 2 2 1 CHC2 zinc finger p450 PF00067.17 CCF47308.1 - 2.2e-08 33.0 0.0 3e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 CENP-B_dimeris PF09026.5 CCF47310.1 - 0.0079 16.4 0.4 0.0091 16.2 0.2 1.2 1 0 0 1 1 1 1 Centromere protein B dimerisation domain RXT2_N PF08595.6 CCF47310.1 - 0.057 13.2 0.2 0.072 12.8 0.1 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal PBP1_TM PF14812.1 CCF47310.1 - 0.1 12.8 0.2 0.1 12.8 0.2 1.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal S-antigen PF05756.6 CCF47310.1 - 0.27 11.2 3.6 0.39 10.7 2.5 1.2 1 0 0 1 1 1 0 S-antigen protein Nucleoplasmin PF03066.10 CCF47310.1 - 0.3 10.5 4.3 0.39 10.2 3.0 1.1 1 0 0 1 1 1 0 Nucleoplasmin BSP_II PF05432.6 CCF47310.1 - 0.41 9.8 5.5 0.55 9.4 3.8 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DNA_pol_phi PF04931.8 CCF47310.1 - 1.5 6.4 9.0 1.9 6.1 6.2 1.0 1 0 0 1 1 1 0 DNA polymerase phi CBF PF03914.12 CCF47311.1 - 5.1e-47 159.3 0.1 7.6e-47 158.8 0.1 1.3 1 0 0 1 1 1 1 CBF/Mak21 family Utp12 PF04003.7 CCF47311.1 - 0.043 13.7 0.2 0.097 12.5 0.1 1.5 1 0 0 1 1 1 0 Dip2/Utp12 Family EIN3 PF04873.8 CCF47311.1 - 0.069 12.3 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Ethylene insensitive 3 CorA PF01544.13 CCF47312.1 - 2.1e-41 141.8 1.3 1.1e-40 139.5 0.9 1.9 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein ERM PF00769.14 CCF47313.1 - 0.01 15.3 2.0 0.032 13.7 0.2 1.9 2 0 0 2 2 2 0 Ezrin/radixin/moesin family AAA_27 PF13514.1 CCF47313.1 - 0.033 11.9 1.3 0.041 11.5 0.9 1.1 1 0 0 1 1 1 0 AAA domain DUF3847 PF12958.2 CCF47313.1 - 0.17 11.6 2.2 6.2 6.6 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3847) DUF896 PF05979.7 CCF47313.1 - 0.45 10.1 2.7 1 8.9 0.4 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) MAD PF05557.8 CCF47315.1 - 4.2e-05 21.8 3.8 4.9e-05 21.6 2.6 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein DUF904 PF06005.7 CCF47315.1 - 0.0048 17.1 4.9 0.0094 16.2 3.4 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF904) ADIP PF11559.3 CCF47315.1 - 0.0078 16.1 2.5 0.0092 15.8 1.7 1.1 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding bZIP_1 PF00170.16 CCF47315.1 - 0.0091 15.9 1.7 0.0091 15.9 1.2 1.9 1 1 0 2 2 2 1 bZIP transcription factor DUF972 PF06156.8 CCF47315.1 - 0.011 16.0 0.8 0.014 15.7 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) IncA PF04156.9 CCF47315.1 - 0.015 14.8 4.7 0.018 14.6 3.3 1.2 1 0 0 1 1 1 0 IncA protein DivIC PF04977.10 CCF47315.1 - 0.021 14.3 2.2 0.021 14.3 1.5 2.0 1 1 1 2 2 2 0 Septum formation initiator HALZ PF02183.13 CCF47315.1 - 0.024 14.3 4.2 0.35 10.6 2.9 2.3 1 1 1 2 2 2 0 Homeobox associated leucine zipper DUF724 PF05266.9 CCF47315.1 - 0.039 13.5 0.5 0.047 13.2 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) CENP-F_leu_zip PF10473.4 CCF47315.1 - 0.088 12.6 6.5 0.15 11.9 4.5 1.3 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1875 PF08961.5 CCF47315.1 - 0.089 12.0 0.4 0.11 11.8 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1875) YscO PF07321.7 CCF47315.1 - 0.09 12.5 6.5 0.12 12.1 4.5 1.2 1 0 0 1 1 1 0 Type III secretion protein YscO Rootletin PF15035.1 CCF47315.1 - 0.093 12.6 3.0 0.12 12.2 2.1 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion phiKZ_IP PF12699.2 CCF47315.1 - 0.11 11.3 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 phiKZ-like phage internal head proteins Fez1 PF06818.10 CCF47315.1 - 0.12 12.4 4.2 0.13 12.2 2.9 1.1 1 0 0 1 1 1 0 Fez1 Atg14 PF10186.4 CCF47315.1 - 0.17 10.7 0.9 0.19 10.6 0.6 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Cep57_MT_bd PF06657.8 CCF47315.1 - 0.19 11.6 0.3 0.19 11.6 0.2 1.7 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 T2SF PF00482.18 CCF47315.1 - 0.2 11.5 1.3 0.24 11.3 0.9 1.1 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F TBPIP PF07106.8 CCF47315.1 - 0.23 10.9 0.8 0.31 10.5 0.5 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMF_DNA_bd PF12329.3 CCF47315.1 - 0.3 10.9 7.8 0.45 10.3 5.4 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding GAS PF13851.1 CCF47315.1 - 0.3 10.2 2.2 0.34 10.0 0.9 1.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding WXG100 PF06013.7 CCF47315.1 - 0.42 10.6 2.0 0.52 10.3 0.2 1.8 2 0 0 2 2 2 0 Proteins of 100 residues with WXG TMF_TATA_bd PF12325.3 CCF47315.1 - 0.48 10.1 5.0 0.83 9.3 0.9 1.9 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding FlgN PF05130.7 CCF47315.1 - 1.1 9.5 7.5 4.8 7.4 5.3 1.8 1 1 0 1 1 1 0 FlgN protein DUF4140 PF13600.1 CCF47315.1 - 1.2 9.5 7.4 4 7.9 5.2 1.8 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) UPF0242 PF06785.6 CCF47315.1 - 1.3 7.6 3.3 1.5 7.4 2.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) FUSC PF04632.7 CCF47315.1 - 3.1 6.1 5.8 3.3 6.0 4.0 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family bZIP_2 PF07716.10 CCF47315.1 - 8.3 6.3 9.2 3.6 7.4 1.9 2.4 1 1 1 2 2 2 0 Basic region leucine zipper zf-C2H2_4 PF13894.1 CCF47316.1 - 1.2e-09 37.7 24.2 0.0011 19.1 0.9 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CCF47316.1 - 6e-08 32.6 25.1 1.7e-06 28.0 0.1 5.3 5 1 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.21 CCF47316.1 - 1.1e-05 25.4 10.2 0.00013 22.1 1.4 4.5 4 1 0 4 4 4 2 Zinc finger, C2H2 type zf-met PF12874.2 CCF47316.1 - 0.0038 17.3 0.8 0.0038 17.3 0.5 2.8 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 CCF47316.1 - 0.014 15.5 1.1 0.014 15.5 0.8 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.5 CCF47316.1 - 0.13 12.2 6.7 2.6 8.0 0.2 3.1 3 0 0 3 3 3 0 Zinc ribbon domain HypA PF01155.14 CCF47316.1 - 0.17 11.6 0.6 0.29 10.8 0.4 1.3 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zf-BED PF02892.10 CCF47316.1 - 0.27 10.9 3.7 0.36 10.6 0.1 2.5 2 0 0 2 2 2 0 BED zinc finger Zn_Tnp_IS1595 PF12760.2 CCF47316.1 - 0.46 10.3 7.1 0.11 12.3 0.7 2.8 3 0 0 3 3 3 0 Transposase zinc-ribbon domain zf-C2H2_6 PF13912.1 CCF47316.1 - 1.4 8.9 8.0 7.8 6.5 0.4 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met2 PF12907.2 CCF47316.1 - 2.1 8.3 5.9 2.8 7.9 1.0 3.0 2 1 1 3 3 3 0 Zinc-binding Mito_fiss_reg PF05308.6 CCF47317.1 - 0.11 11.8 1.3 0.16 11.3 0.9 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator CDO_I PF05995.7 CCF47321.1 - 2.1e-07 30.3 0.0 2.4e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I SBF2 PF12335.3 CCF47321.1 - 0.13 11.5 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Myotubularin protein SLAC1 PF03595.12 CCF47322.1 - 3.9e-59 199.9 33.0 4.6e-59 199.7 22.9 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Radical_SAM PF04055.16 CCF47323.1 - 1.4e-24 87.1 0.1 8.5e-24 84.5 0.0 2.2 2 0 0 2 2 2 1 Radical SAM superfamily Wyosine_form PF08608.7 CCF47323.1 - 2.4e-23 82.0 0.0 7.5e-23 80.4 0.0 2.0 1 0 0 1 1 1 1 Wyosine base formation Flavodoxin_1 PF00258.20 CCF47323.1 - 2.6e-11 43.7 0.3 2.7e-09 37.1 0.1 3.3 2 1 0 2 2 2 1 Flavodoxin MAS20 PF02064.10 CCF47324.1 - 5.6e-12 45.6 1.3 5.9e-11 42.3 0.9 1.9 1 1 0 1 1 1 1 MAS20 protein import receptor Rhabdo_ncap PF00945.13 CCF47324.1 - 0.0063 15.1 1.3 0.0076 14.8 0.9 1.1 1 0 0 1 1 1 1 Rhabdovirus nucleocapsid protein Peptidase_C8 PF03569.8 CCF47324.1 - 0.017 14.4 2.5 0.18 11.0 1.8 2.0 1 1 0 1 1 1 0 Peptidase family C8 DUF533 PF04391.7 CCF47324.1 - 0.019 14.3 2.4 0.024 13.9 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF533) CCDC66 PF15236.1 CCF47324.1 - 0.024 14.2 12.3 0.034 13.7 8.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 66 DUF4231 PF14015.1 CCF47324.1 - 0.034 14.1 0.6 0.056 13.4 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) NAM-associated PF14303.1 CCF47324.1 - 0.034 14.4 4.0 0.043 14.1 2.8 1.1 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain DUF3824 PF12868.2 CCF47324.1 - 0.099 13.5 2.4 0.15 12.9 1.7 1.3 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) AP-5_subunit_s1 PF15001.1 CCF47324.1 - 0.28 11.1 1.7 0.32 10.8 1.2 1.1 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 Vps51 PF08700.6 CCF47325.1 - 3e-15 55.8 1.8 3e-15 55.8 1.3 2.3 3 0 0 3 3 3 1 Vps51/Vps67 Sec5 PF15469.1 CCF47325.1 - 0.0039 16.9 6.0 0.9 9.2 1.6 2.8 2 1 0 2 2 2 2 Exocyst complex component Sec5 Laminin_B PF00052.13 CCF47325.1 - 0.0054 16.3 0.2 0.013 15.1 0.1 1.6 1 0 0 1 1 1 1 Laminin B (Domain IV) COG2 PF06148.6 CCF47325.1 - 0.0063 16.3 2.6 0.03 14.1 0.0 2.4 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF3010 PF11215.3 CCF47325.1 - 0.014 15.3 0.2 0.053 13.4 0.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3010) DASH_Dam1 PF08653.5 CCF47325.1 - 3.3 7.5 4.8 34 4.2 0.1 3.2 3 0 0 3 3 3 0 DASH complex subunit Dam1 Atg14 PF10186.4 CCF47325.1 - 6.9 5.5 11.9 1.7 7.5 2.1 2.3 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 SnoaL PF07366.7 CCF47330.1 - 8.5e-19 67.3 0.0 9.9e-19 67.1 0.0 1.0 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.2 CCF47330.1 - 7.4e-08 32.7 0.0 1.1e-07 32.1 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF3622 PF12286.3 CCF47330.1 - 0.13 12.5 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3622) Fungal_trans PF04082.13 CCF47331.1 - 8.5e-19 67.4 0.0 1.2e-18 66.9 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF47331.1 - 8.4e-11 41.5 10.2 1.6e-10 40.7 7.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ETC_C1_NDUFA5 PF04716.9 CCF47331.1 - 0.016 14.7 0.0 2.2 7.8 0.0 2.4 2 0 0 2 2 2 0 ETC complex I subunit conserved region MFS_1 PF07690.11 CCF47332.1 - 7.9e-28 97.1 26.0 7.9e-28 97.1 18.0 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Xpo1 PF08389.7 CCF47336.1 - 1.1e-42 145.4 6.1 3.2e-42 143.9 4.2 1.9 1 0 0 1 1 1 1 Exportin 1-like protein HD_assoc PF13286.1 CCF47336.1 - 0.002 18.3 0.1 3.4 8.0 0.1 2.5 2 0 0 2 2 2 2 Phosphohydrolase-associated domain Glyoxalase PF00903.20 CCF47337.1 - 0.00017 21.5 1.3 0.00022 21.1 0.9 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily zf-RING_2 PF13639.1 CCF47338.1 - 9.3e-11 41.3 4.9 1.4e-10 40.7 3.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 CCF47338.1 - 4.6e-07 29.8 2.5 9e-07 28.9 1.7 1.5 1 1 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 CCF47338.1 - 1.1e-06 28.3 0.8 1.9e-06 27.6 0.6 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.1 CCF47338.1 - 2.9e-05 23.9 4.7 4.6e-05 23.3 3.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CCF47338.1 - 3.2e-05 23.5 1.9 5.2e-05 22.8 1.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF47338.1 - 0.0013 18.3 2.8 0.0023 17.5 1.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.3 CCF47338.1 - 0.0072 16.2 2.6 0.23 11.4 1.8 2.4 1 1 0 1 1 1 1 FANCL C-terminal domain zf-RING_4 PF14570.1 CCF47338.1 - 0.0079 15.7 3.1 0.02 14.4 2.2 1.7 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain Rad50_zn_hook PF04423.9 CCF47338.1 - 0.016 14.6 2.5 0.76 9.2 0.1 2.6 2 1 1 3 3 3 0 Rad50 zinc hook motif zf-RING_5 PF14634.1 CCF47338.1 - 0.017 14.8 2.1 0.03 14.0 1.5 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-Di19 PF05605.7 CCF47338.1 - 0.067 13.3 1.9 10 6.3 0.3 2.5 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Tmpp129 PF10272.4 CCF47338.1 - 0.11 11.2 0.7 0.43 9.2 0.2 1.9 2 0 0 2 2 2 0 Putative transmembrane protein precursor Prok-RING_1 PF14446.1 CCF47338.1 - 0.14 11.8 3.3 6.1 6.6 0.1 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_3 PF14369.1 CCF47338.1 - 0.19 11.7 1.4 1.5 8.9 0.0 2.5 2 0 0 2 2 2 0 zinc-finger zf-UDP PF14569.1 CCF47338.1 - 0.44 10.3 2.5 0.45 10.2 0.5 1.9 1 1 1 2 2 2 0 Zinc-binding RING-finger zf-P11 PF03854.9 CCF47338.1 - 0.71 9.3 3.8 4.1 6.9 0.9 2.2 2 0 0 2 2 2 0 P-11 zinc finger Fungal_trans PF04082.13 CCF47339.1 - 1e-23 83.5 0.0 1.5e-23 83.0 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DLH PF01738.13 CCF47340.1 - 6.8e-18 64.7 0.0 7.8e-18 64.5 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.15 CCF47340.1 - 2.8e-05 23.7 0.0 3.8e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CCF47340.1 - 0.00031 20.5 0.0 0.00043 20.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CCF47340.1 - 0.0034 17.2 0.0 0.0045 16.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase PF07224.6 CCF47340.1 - 0.015 14.1 0.0 0.023 13.5 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Translin PF01997.11 CCF47341.1 - 5.6e-32 110.9 0.4 6.3e-32 110.8 0.3 1.0 1 0 0 1 1 1 1 Translin family GMP_synt_C PF00958.17 CCF47341.1 - 0.039 13.6 0.0 0.053 13.2 0.0 1.3 1 0 0 1 1 1 0 GMP synthase C terminal domain Gpi1 PF05024.10 CCF47341.1 - 0.078 12.6 0.1 0.095 12.3 0.1 1.3 1 0 0 1 1 1 0 N-acetylglucosaminyl transferase component (Gpi1) Ank_5 PF13857.1 CCF47342.1 - 0.0016 18.6 0.1 0.0062 16.7 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 CCF47342.1 - 0.013 16.0 0.3 9.6 6.8 0.0 2.7 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Methyltransf_23 PF13489.1 CCF47343.1 - 1.2e-18 67.3 0.0 2.3e-18 66.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF47343.1 - 1.4e-12 48.1 0.0 1.7e-11 44.6 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF47343.1 - 2e-11 43.7 0.0 1.5e-10 40.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF47343.1 - 6.5e-08 32.9 0.0 1.7e-07 31.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF47343.1 - 0.0002 21.7 0.0 0.0033 17.8 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF47343.1 - 0.00052 20.3 0.0 0.0014 18.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF47343.1 - 0.0016 18.4 0.0 0.0043 17.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 CCF47343.1 - 0.0023 17.9 0.0 0.0035 17.3 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.9 CCF47343.1 - 0.004 16.5 0.0 0.0084 15.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.12 CCF47343.1 - 0.005 15.9 0.0 0.012 14.6 0.0 1.5 2 0 0 2 2 2 1 Putative methyltransferase CheR PF01739.13 CCF47343.1 - 0.0083 15.4 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_16 PF10294.4 CCF47343.1 - 0.019 14.4 0.0 0.032 13.6 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase PrmA PF06325.8 CCF47343.1 - 0.02 14.0 0.0 0.029 13.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.13 CCF47343.1 - 0.13 11.4 0.0 0.26 10.4 0.0 1.6 2 0 0 2 2 2 0 O-methyltransferase Toxin_3 PF00537.13 CCF47344.1 - 0.043 13.7 0.3 0.92 9.4 0.1 2.2 2 0 0 2 2 2 0 Scorpion toxin-like domain CBM_1 PF00734.13 CCF47345.1 - 3.6e-13 48.9 10.0 3.6e-13 48.9 6.9 2.1 2 0 0 2 2 2 1 Fungal cellulose binding domain Toxin_7 PF05980.7 CCF47345.1 - 0.12 12.3 0.5 0.3 11.1 0.4 1.7 1 0 0 1 1 1 0 Toxin 7 4HBT PF03061.17 CCF47347.1 - 2.1e-07 30.9 0.2 3.5e-07 30.2 0.1 1.4 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.1 CCF47347.1 - 0.02 14.6 0.1 0.026 14.2 0.1 1.2 1 0 0 1 1 1 0 Thioesterase-like superfamily MARVEL PF01284.18 CCF47348.1 - 6.9e-05 22.7 15.3 9.8e-05 22.2 10.6 1.2 1 0 0 1 1 1 1 Membrane-associating domain UPF0104 PF03706.8 CCF47348.1 - 0.17 11.1 13.7 0.02 14.2 6.5 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0104) 7TMR-DISM_7TM PF07695.6 CCF47348.1 - 0.28 10.8 16.8 0.29 10.7 8.3 2.0 2 0 0 2 2 2 0 7TM diverse intracellular signalling UNC-50 PF05216.8 CCF47348.1 - 0.75 8.9 9.5 0.049 12.8 2.6 1.8 2 0 0 2 2 2 0 UNC-50 family Myc_target_1 PF15179.1 CCF47348.1 - 10 5.6 10.0 4 6.9 2.9 2.1 2 0 0 2 2 2 0 Myc target protein 1 DUF1772 PF08592.6 CCF47351.1 - 1.4e-25 89.6 9.2 1.9e-25 89.2 6.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) MFS_1 PF07690.11 CCF47352.1 - 7.7e-16 57.7 18.5 9.4e-16 57.4 12.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 CCF47352.1 - 1.8e-05 23.3 6.6 2.5e-05 22.8 4.5 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1_like PF12832.2 CCF47352.1 - 0.0058 16.3 0.1 0.011 15.4 0.1 1.5 1 0 0 1 1 1 1 MFS_1 like family HET PF06985.6 CCF47353.1 - 5.3e-33 114.1 0.1 9.5e-33 113.2 0.1 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Methyltransf_11 PF08241.7 CCF47354.1 - 9.3e-14 51.7 0.0 1.8e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CCF47354.1 - 3.7e-12 45.8 0.0 7.5e-12 44.8 0.0 1.4 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 CCF47354.1 - 2.9e-11 43.1 0.0 3.5e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF47354.1 - 3.3e-09 36.9 0.0 6.8e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF47354.1 - 4.9e-09 36.5 0.0 7.7e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF47354.1 - 1.9e-07 30.9 0.0 2.9e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CCF47354.1 - 8.7e-05 22.5 0.0 0.00027 20.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF47354.1 - 0.0012 19.3 0.0 0.0022 18.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF47354.1 - 0.0053 16.1 0.1 0.012 14.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.1 CCF47354.1 - 0.071 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain S19 PF06756.6 CCF47355.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Chorion protein S19 C-terminal Peptidase_S8 PF00082.17 CCF47359.1 - 9.7e-08 31.4 1.5 1.6e-07 30.7 0.7 1.7 2 0 0 2 2 2 1 Subtilase family Cytochrom_C PF00034.16 CCF47361.1 - 1.7e-11 44.8 0.0 2.5e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.1 CCF47361.1 - 3.5e-09 36.6 2.6 1.8e-08 34.3 1.8 1.8 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.1 CCF47361.1 - 0.0022 17.4 0.4 0.026 13.9 0.1 2.2 2 0 0 2 2 2 1 Cytochrome c-550 domain AAA PF00004.24 CCF47362.1 - 3.2e-64 215.0 0.0 2e-45 154.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CCF47362.1 - 1.7e-10 41.1 0.1 0.0026 17.8 0.0 5.9 5 2 0 5 5 4 2 AAA domain AAA_16 PF13191.1 CCF47362.1 - 5e-10 39.6 3.9 4.4e-05 23.5 0.0 4.6 4 2 1 5 5 4 2 AAA ATPase domain AAA_5 PF07728.9 CCF47362.1 - 1.6e-08 34.4 0.1 0.0016 18.1 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 CCF47362.1 - 1.8e-08 35.2 1.0 0.0064 17.3 0.0 3.4 3 2 0 3 3 2 2 AAA domain Zeta_toxin PF06414.7 CCF47362.1 - 7e-08 31.8 1.8 0.00041 19.5 0.0 3.7 4 0 0 4 4 4 2 Zeta toxin AAA_33 PF13671.1 CCF47362.1 - 1e-06 28.6 0.0 0.0023 17.7 0.0 3.1 3 1 0 3 3 2 2 AAA domain AAA_14 PF13173.1 CCF47362.1 - 1.1e-06 28.5 0.0 0.0021 17.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 CCF47362.1 - 1.2e-06 28.9 0.4 0.032 14.5 0.0 3.0 3 0 0 3 3 2 2 AAA domain Sigma54_activ_2 PF14532.1 CCF47362.1 - 3.3e-06 27.1 0.0 0.072 13.1 0.0 3.1 2 1 0 2 2 2 2 Sigma-54 interaction domain RuvB_N PF05496.7 CCF47362.1 - 3.9e-06 26.0 0.0 0.00038 19.5 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 CCF47362.1 - 4.3e-06 26.3 0.1 0.032 13.9 0.0 3.2 2 0 0 2 2 2 2 Part of AAA domain AAA_25 PF13481.1 CCF47362.1 - 8.1e-06 25.3 0.8 3.5 6.9 0.0 4.4 2 2 1 4 4 4 1 AAA domain IstB_IS21 PF01695.12 CCF47362.1 - 5.8e-05 22.5 0.0 0.022 14.1 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_2 PF07724.9 CCF47362.1 - 8.6e-05 22.5 0.0 0.0014 18.5 0.0 2.6 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.17 CCF47362.1 - 0.00036 20.6 0.0 0.043 13.9 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_28 PF13521.1 CCF47362.1 - 0.00038 20.4 5.0 0.35 10.8 0.0 3.9 4 1 1 5 5 4 2 AAA domain Mg_chelatase PF01078.16 CCF47362.1 - 0.00063 18.9 0.1 0.092 11.8 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.8 CCF47362.1 - 0.00072 18.5 0.0 0.61 8.9 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Sigma54_activat PF00158.21 CCF47362.1 - 0.00075 19.0 0.0 0.59 9.5 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_24 PF13479.1 CCF47362.1 - 0.00087 18.9 0.0 1.1 8.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain Vps4_C PF09336.5 CCF47362.1 - 0.001 18.8 0.1 0.75 9.7 0.0 3.4 3 0 0 3 3 3 1 Vps4 C terminal oligomerisation domain NACHT PF05729.7 CCF47362.1 - 0.0023 17.6 0.0 2.6 7.6 0.0 3.8 3 1 1 4 4 4 1 NACHT domain AAA_11 PF13086.1 CCF47362.1 - 0.0025 17.4 0.6 0.73 9.3 0.0 2.9 3 0 0 3 3 3 1 AAA domain Rad17 PF03215.10 CCF47362.1 - 0.0033 16.1 0.0 0.24 10.0 0.0 2.2 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein ATP-synt_ab PF00006.20 CCF47362.1 - 0.0061 16.0 0.0 0.44 10.0 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain TIP49 PF06068.8 CCF47362.1 - 0.0066 15.2 0.0 0.22 10.2 0.0 2.2 2 0 0 2 2 2 1 TIP49 C-terminus Arch_ATPase PF01637.13 CCF47362.1 - 0.02 14.5 0.1 5.8 6.5 0.0 3.2 3 1 1 4 4 3 0 Archaeal ATPase ABC_tran PF00005.22 CCF47362.1 - 0.021 15.1 0.1 2.1 8.6 0.0 2.9 3 0 0 3 3 2 0 ABC transporter NB-ARC PF00931.17 CCF47362.1 - 0.026 13.3 0.0 0.098 11.4 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain AAA_3 PF07726.6 CCF47362.1 - 0.034 13.7 0.0 1.7 8.2 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.13 CCF47362.1 - 0.058 12.9 0.0 1.1 8.7 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.10 CCF47362.1 - 0.073 12.7 0.0 12 5.5 0.0 2.6 2 0 0 2 2 2 0 NTPase SKI PF01202.17 CCF47362.1 - 0.074 12.9 0.4 3.6 7.4 0.0 3.1 3 0 0 3 3 3 0 Shikimate kinase AAA_10 PF12846.2 CCF47362.1 - 0.08 12.3 0.0 11 5.3 0.0 3.1 3 0 0 3 3 3 0 AAA-like domain IPT PF01745.11 CCF47362.1 - 0.084 12.0 0.7 4.9 6.2 0.0 2.8 3 0 0 3 3 3 0 Isopentenyl transferase CRM1_C PF08767.6 CCF47363.1 - 1.2e-134 448.2 3.4 1.2e-134 448.2 2.3 2.4 2 1 0 2 2 2 1 CRM1 C terminal DUF3385 PF11865.3 CCF47363.1 - 0.044 13.7 4.0 0.088 12.7 0.0 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF3385) C8 PF08742.6 CCF47363.1 - 0.11 12.7 0.1 0.61 10.3 0.0 2.2 2 0 0 2 2 2 0 C8 domain uDENN PF03456.13 CCF47363.1 - 0.17 11.8 0.7 5.9 6.9 0.1 3.0 3 0 0 3 3 3 0 uDENN domain FliH PF02108.11 CCF47363.1 - 0.45 10.4 2.8 1.5 8.7 0.0 2.9 3 0 0 3 3 3 0 Flagellar assembly protein FliH Vac14_Fab1_bd PF12755.2 CCF47363.1 - 0.55 10.6 7.6 1.8 9.0 0.0 4.4 5 1 1 6 6 6 0 Vacuolar 14 Fab1-binding region SDH_beta PF03315.10 CCF47364.1 - 0.064 13.3 0.2 0.092 12.8 0.1 1.2 1 0 0 1 1 1 0 Serine dehydratase beta chain Fungal_trans PF04082.13 CCF47365.1 - 1.8e-12 46.7 0.1 4.9e-12 45.2 0.0 1.7 1 1 0 2 2 2 1 Fungal specific transcription factor domain Ribosomal_L13 PF00572.13 CCF47368.1 - 2.1e-27 95.6 0.3 3.7e-27 94.9 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L13 DSBA PF01323.15 CCF47368.1 - 0.012 15.2 0.1 0.017 14.6 0.1 1.2 1 1 0 1 1 1 0 DSBA-like thioredoxin domain Pyr_redox_2 PF07992.9 CCF47369.1 - 5.9e-05 23.0 0.0 0.00035 20.5 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF47369.1 - 0.0048 16.9 0.0 0.015 15.3 0.0 1.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF47369.1 - 0.0054 15.6 0.0 0.0079 15.1 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 CCF47369.1 - 0.0059 16.3 0.0 0.022 14.5 0.0 1.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding Malic_M PF03949.10 CCF47369.1 - 0.075 12.5 0.0 0.17 11.3 0.0 1.5 2 0 0 2 2 2 0 Malic enzyme, NAD binding domain Methyltransf_24 PF13578.1 CCF47370.1 - 2.2e-05 25.2 0.0 3e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain zf-C2H2 PF00096.21 CCF47372.1 - 4.3e-06 26.7 3.7 4.3e-06 26.7 2.6 4.6 4 1 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CCF47372.1 - 3.4e-05 23.9 4.4 3.4e-05 23.9 3.0 4.7 5 1 0 5 5 5 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 CCF47372.1 - 0.0002 21.4 1.1 0.0002 21.4 0.8 4.9 5 0 0 5 5 5 2 C2H2-type zinc finger Glyco_hydro_3 PF00933.16 CCF47374.1 - 0.0017 17.3 0.0 0.0022 17.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain GATA PF00320.22 CCF47376.1 - 2.3e-10 39.6 1.0 4.5e-10 38.6 0.7 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF3405 PF11885.3 CCF47377.1 - 3.4e-45 154.2 0.2 3.8e-45 154.0 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) bZIP_1 PF00170.16 CCF47378.1 - 4.1e-08 33.0 15.4 8.1e-08 32.1 10.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.12 CCF47378.1 - 0.0022 18.2 10.9 0.0034 17.6 7.6 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor DUF972 PF06156.8 CCF47378.1 - 0.016 15.5 0.3 0.029 14.7 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) V_ATPase_I PF01496.14 CCF47378.1 - 0.02 12.8 1.3 0.024 12.5 0.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CCDC155 PF14662.1 CCF47378.1 - 0.02 14.4 8.8 0.031 13.8 6.1 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 ADIP PF11559.3 CCF47378.1 - 0.027 14.3 11.2 0.041 13.7 7.7 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding BLOC1_2 PF10046.4 CCF47378.1 - 0.034 14.2 1.5 0.058 13.5 1.0 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DivIC PF04977.10 CCF47378.1 - 0.06 12.8 4.9 0.12 11.8 3.4 1.4 1 0 0 1 1 1 0 Septum formation initiator bZIP_2 PF07716.10 CCF47378.1 - 0.07 12.9 18.3 0.13 12.1 11.9 1.9 1 1 1 2 2 2 0 Basic region leucine zipper DUF641 PF04859.7 CCF47378.1 - 0.077 12.7 5.8 0.12 12.1 4.0 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) NAM-associated PF14303.1 CCF47378.1 - 0.079 13.2 9.8 0.11 12.7 6.8 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain AAA_11 PF13086.1 CCF47378.1 - 0.28 10.7 3.3 0.39 10.2 2.3 1.1 1 0 0 1 1 1 0 AAA domain Glutaredoxin2_C PF04399.8 CCF47378.1 - 0.34 10.5 2.6 0.53 9.8 1.8 1.2 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain IncA PF04156.9 CCF47378.1 - 0.47 10.0 3.7 0.65 9.5 2.6 1.2 1 0 0 1 1 1 0 IncA protein LMSTEN PF07988.7 CCF47378.1 - 0.98 8.7 6.0 16 4.8 0.6 2.8 1 1 1 2 2 2 0 LMSTEN motif DDRGK PF09756.4 CCF47378.1 - 1.3 8.4 9.9 1.8 7.9 6.8 1.1 1 0 0 1 1 1 0 DDRGK domain APG6 PF04111.7 CCF47378.1 - 2.5 7.0 6.7 3.2 6.7 4.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 M PF02370.11 CCF47378.1 - 6.2 7.5 8.1 1.1 9.7 2.5 2.1 2 0 0 2 2 2 0 M protein repeat PAT1 PF09770.4 CCF47378.1 - 9.1 4.3 25.1 12 4.0 17.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MFS_1 PF07690.11 CCF47379.1 - 9.5e-22 77.1 30.1 9.5e-22 77.1 20.8 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Multi_Drug_Res PF00893.14 CCF47379.1 - 0.25 11.8 4.4 3.7 8.0 0.0 3.3 2 1 1 3 3 3 0 Small Multidrug Resistance protein Peptidase_A24 PF01478.13 CCF47379.1 - 1.8 8.7 15.3 0.24 11.5 1.2 3.0 2 2 1 3 3 3 0 Type IV leader peptidase family FA_desaturase PF00487.19 CCF47379.1 - 6.2 6.1 12.5 9 5.6 3.2 2.5 2 1 0 2 2 2 0 Fatty acid desaturase LysM PF01476.15 CCF47381.1 - 3.4e-14 52.4 0.0 1.1e-06 28.3 0.0 3.2 3 0 0 3 3 3 2 LysM domain RbcS PF12338.3 CCF47381.1 - 0.037 13.8 0.6 0.037 13.8 0.4 3.9 4 1 1 5 5 5 0 Ribulose-1,5-bisphosphate carboxylase small subunit Mucin PF01456.12 CCF47381.1 - 0.25 11.1 19.4 0.23 11.2 9.8 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein UPF0104 PF03706.8 CCF47383.1 - 0.12 11.6 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0104) Dak1 PF02733.12 CCF47384.1 - 4.3e-47 160.2 0.5 4.7e-47 160.1 0.4 1.0 1 0 0 1 1 1 1 Dak1 domain DUF605 PF04652.11 CCF47385.1 - 1.9 7.8 19.7 2.7 7.3 13.6 1.2 1 0 0 1 1 1 0 Vta1 like EF-hand_7 PF13499.1 CCF47386.1 - 4.7e-07 29.8 0.2 1.2e-06 28.4 0.0 1.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 CCF47386.1 - 0.00014 20.8 3.3 0.25 10.7 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 CCF47386.1 - 0.087 12.7 1.4 0.52 10.3 0.1 2.6 3 0 0 3 3 3 0 EF-hand domain Gar1 PF04410.9 CCF47388.1 - 6.5e-24 84.1 0.1 6.5e-24 84.1 0.1 1.9 3 0 0 3 3 3 1 Gar1/Naf1 RNA binding region Abhydrolase_4 PF08386.5 CCF47389.1 - 2.9e-13 49.5 0.0 5.2e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.15 CCF47389.1 - 3.3e-11 43.1 0.0 5.6e-10 39.1 0.0 2.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF47389.1 - 2.7e-07 30.6 0.2 1.9e-05 24.6 0.1 3.0 1 1 0 2 2 2 1 Alpha/beta hydrolase family zf-C2H2_4 PF13894.1 CCF47390.1 - 5e-06 26.4 12.8 0.0015 18.7 0.2 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF47390.1 - 0.00045 20.3 0.5 0.00045 20.3 0.4 4.0 3 2 0 3 3 3 2 Zinc finger, C2H2 type zf-Di19 PF05605.7 CCF47390.1 - 0.011 15.8 6.8 0.14 12.3 0.5 2.7 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.1 CCF47390.1 - 0.027 14.1 5.8 0.43 10.3 0.1 3.4 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-H2C2_2 PF13465.1 CCF47390.1 - 0.029 14.6 17.4 0.096 13.0 0.7 4.4 4 0 0 4 4 4 0 Zinc-finger double domain ROS_MUCR PF05443.6 CCF47390.1 - 0.17 11.6 0.1 3.4 7.4 0.1 2.4 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein zf-H2C2_5 PF13909.1 CCF47390.1 - 0.48 10.7 10.3 9.8 6.6 1.0 4.0 2 1 2 4 4 4 0 C2H2-type zinc-finger domain zf-BED PF02892.10 CCF47390.1 - 0.73 9.6 7.5 0.56 9.9 2.0 2.6 2 1 0 2 2 2 0 BED zinc finger zf-C2H2_2 PF12756.2 CCF47390.1 - 1.4 9.0 6.8 8.4 6.5 0.3 2.7 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 CCF47390.1 - 4.9 7.4 7.8 1.8 8.8 0.2 3.4 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding p450 PF00067.17 CCF47392.1 - 2.3e-05 23.1 0.0 2.7e-05 22.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 LysM PF01476.15 CCF47393.1 - 3.6e-05 23.5 0.0 4.7e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 LysM domain FAT PF02259.18 CCF47395.1 - 8.4e-10 38.1 0.0 1.4e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 FAT domain TPR_19 PF14559.1 CCF47395.1 - 0.0016 18.7 0.2 0.017 15.4 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat LSM14 PF12701.2 CCF47396.1 - 4.2e-35 119.4 0.0 5.6e-35 119.0 0.0 1.2 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.1 CCF47396.1 - 1.3e-06 28.1 0.0 2e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain TPR_1 PF00515.23 CCF47397.1 - 4.4e-45 149.4 26.2 1.2e-08 34.1 0.0 9.0 9 1 0 9 9 9 6 Tetratricopeptide repeat TPR_11 PF13414.1 CCF47397.1 - 1.5e-42 143.0 21.3 2.5e-14 52.6 0.9 5.2 2 2 3 6 6 6 6 TPR repeat TPR_2 PF07719.12 CCF47397.1 - 1e-39 131.2 19.1 4.4e-07 29.3 0.0 8.4 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.1 CCF47397.1 - 6.7e-31 103.7 19.1 1.4e-06 27.6 0.0 7.9 6 1 2 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.1 CCF47397.1 - 1.2e-30 105.4 12.4 2.9e-09 37.3 0.0 5.2 3 2 2 5 5 5 5 Tetratricopeptide repeat TPR_17 PF13431.1 CCF47397.1 - 2.9e-27 92.5 9.0 0.00044 20.2 0.0 8.2 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.1 CCF47397.1 - 5.1e-25 87.2 17.3 1.5e-07 31.2 0.1 5.9 2 2 4 6 6 6 6 Tetratricopeptide repeat TPR_14 PF13428.1 CCF47397.1 - 1e-22 78.5 11.8 2.2e-05 24.6 0.0 7.5 3 2 5 8 8 8 6 Tetratricopeptide repeat TPR_7 PF13176.1 CCF47397.1 - 3.7e-22 76.2 10.0 0.0004 19.9 0.0 7.6 7 1 0 7 7 7 5 Tetratricopeptide repeat TPR_6 PF13174.1 CCF47397.1 - 3e-21 74.3 14.7 0.00018 21.7 0.0 7.9 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.1 CCF47397.1 - 7.4e-20 71.0 13.6 5.7e-05 23.3 0.1 5.5 4 2 1 5 5 5 5 Tetratricopeptide repeat TPR_9 PF13371.1 CCF47397.1 - 3.9e-13 49.0 10.3 0.00021 21.0 0.1 5.4 1 1 5 6 6 6 5 Tetratricopeptide repeat Apc3 PF12895.2 CCF47397.1 - 9.4e-13 48.1 8.1 6.7e-09 35.7 0.7 3.9 2 2 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.1 CCF47397.1 - 4.5e-09 35.7 6.2 0.022 13.8 1.2 4.8 1 1 2 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.1 CCF47397.1 - 0.00015 21.5 11.3 5.4 7.0 0.1 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat DUF2225 PF09986.4 CCF47397.1 - 0.00024 20.6 1.3 0.41 10.0 0.0 3.3 1 1 2 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_21 PF09976.4 CCF47397.1 - 0.00036 20.4 15.6 0.0075 16.2 0.0 4.5 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_20 PF14561.1 CCF47397.1 - 0.00046 20.2 1.3 0.071 13.2 0.0 3.9 4 2 2 6 6 5 1 Tetratricopeptide repeat GAS PF13851.1 CCF47397.1 - 0.0036 16.5 0.3 0.015 14.4 0.1 2.0 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding Fis1_TPR_C PF14853.1 CCF47397.1 - 0.0046 16.8 0.1 6.6 6.7 0.0 3.8 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Foie-gras_1 PF11817.3 CCF47397.1 - 0.075 12.5 8.9 0.89 8.9 1.3 3.2 1 1 1 2 2 2 0 Foie gras liver health family 1 SNAP PF14938.1 CCF47397.1 - 0.1 11.7 16.3 2.8 7.0 0.2 4.1 2 1 2 4 4 3 0 Soluble NSF attachment protein, SNAP MIT PF04212.13 CCF47397.1 - 0.51 10.2 17.5 0.95 9.3 0.7 5.4 6 0 0 6 6 5 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.7 CCF47397.1 - 3.5 8.4 10.7 71 4.2 2.1 4.9 4 1 0 4 4 4 0 Sel1 repeat MFS_1 PF07690.11 CCF47399.1 - 6.8e-16 57.9 34.1 6.8e-16 57.9 23.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily p450 PF00067.17 CCF47400.1 - 2.2e-37 128.6 0.0 3e-37 128.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 CCF47401.1 - 8e-72 242.2 0.0 1.1e-71 241.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 CCF47402.1 - 3.1e-33 115.0 0.0 3.6e-33 114.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 GST_C_3 PF14497.1 CCF47404.1 - 2.8e-08 34.1 0.0 5.8e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 CCF47404.1 - 0.0073 16.1 0.0 0.014 15.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain UPF0183 PF03676.9 CCF47405.1 - 1.1e-37 129.5 0.0 2.5e-23 82.3 0.0 4.6 4 1 0 4 4 4 4 Uncharacterised protein family (UPF0183) Acetyltransf_1 PF00583.19 CCF47406.1 - 1.2e-07 31.6 0.3 1.9e-07 31.0 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 CCF47406.1 - 0.0019 18.2 0.5 0.005 16.9 0.2 1.9 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 CCF47406.1 - 0.0041 17.2 0.1 0.007 16.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Kinesin PF00225.18 CCF47407.1 - 1e-107 359.7 0.0 1e-107 359.7 0.0 2.2 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bind PF13931.1 CCF47407.1 - 8.2e-07 29.2 0.5 8.2e-07 29.2 0.4 5.6 3 2 3 6 6 6 1 Kinesin-associated microtubule-binding Apolipoprotein PF01442.13 CCF47407.1 - 0.00048 19.6 62.6 0.044 13.2 15.1 4.6 1 1 2 3 3 3 2 Apolipoprotein A1/A4/E domain DUF479 PF04336.7 CCF47407.1 - 4.7 7.3 16.3 0.13 12.3 0.4 5.3 4 2 0 4 4 4 0 Protein of unknown function, DUF479 HTH_psq PF05225.11 CCF47408.1 - 1.4e-12 46.9 0.2 1.9e-12 46.5 0.1 1.2 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.1 CCF47408.1 - 0.00017 21.1 0.1 0.00046 19.7 0.0 1.8 1 1 1 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 CCF47408.1 - 0.00034 20.5 0.0 0.00067 19.5 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_Tc5 PF03221.11 CCF47408.1 - 0.00061 19.5 0.0 0.0024 17.6 0.0 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 CCF47408.1 - 0.0039 16.5 0.0 0.0055 16.1 0.0 1.2 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_8 PF02954.14 CCF47408.1 - 0.043 13.3 1.4 0.17 11.4 0.0 2.4 2 1 1 3 3 3 0 Bacterial regulatory protein, Fis family Phage_CP76 PF06892.6 CCF47408.1 - 0.051 12.8 0.0 0.063 12.6 0.0 1.1 1 0 0 1 1 1 0 Phage regulatory protein CII (CP76) HTH_Tnp_ISL3 PF13542.1 CCF47408.1 - 0.056 12.6 0.0 0.091 11.9 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_29 PF13551.1 CCF47408.1 - 0.066 13.3 0.2 0.16 12.1 0.2 1.6 1 1 0 1 1 1 0 Winged helix-turn helix DUF1529 PF07485.6 CCF47408.1 - 0.095 12.4 0.0 0.16 11.6 0.0 1.6 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1259) SCIMP PF15050.1 CCF47410.1 - 0.64 9.9 3.5 1.8 8.4 2.2 1.7 1 1 1 2 2 2 0 SCIMP protein Sugar_tr PF00083.19 CCF47413.1 - 4.1e-15 55.2 0.3 4.5e-15 55.1 0.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF47413.1 - 0.00047 18.9 0.1 0.00051 18.8 0.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily CoaE PF01121.15 CCF47413.1 - 0.0017 17.7 0.0 0.002 17.5 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase MFS_2 PF13347.1 CCF47413.1 - 0.03 12.7 0.3 0.033 12.6 0.2 1.0 1 0 0 1 1 1 0 MFS/sugar transport protein SET PF00856.23 CCF47414.1 - 1.3e-11 45.0 0.1 5.3e-09 36.5 0.1 2.3 1 1 0 1 1 1 1 SET domain SAF PF08666.7 CCF47414.1 - 0.033 14.5 0.1 9.2 6.7 0.0 2.5 2 0 0 2 2 2 0 SAF domain MFS_1 PF07690.11 CCF47415.1 - 5.8e-19 68.0 10.8 6.8e-19 67.7 7.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF486 PF04342.7 CCF47415.1 - 0.037 14.0 0.9 0.071 13.1 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF486 XhlA PF10779.4 CCF47415.1 - 0.25 11.2 1.0 0.63 10.0 0.7 1.6 1 0 0 1 1 1 0 Haemolysin XhlA FAD_binding_3 PF01494.14 CCF47417.1 - 1.4e-72 244.7 0.0 1.7e-72 244.4 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 CCF47417.1 - 1.9e-05 23.7 0.0 0.015 14.2 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 CCF47417.1 - 0.019 13.8 0.0 0.036 13.0 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.12 CCF47417.1 - 0.037 13.1 0.0 0.066 12.2 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.9 CCF47417.1 - 0.039 13.8 0.0 0.076 12.8 0.0 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.5 CCF47417.1 - 0.048 12.4 0.0 0.22 10.3 0.0 1.8 2 0 0 2 2 2 0 Squalene epoxidase NAD_binding_8 PF13450.1 CCF47417.1 - 0.048 13.6 0.0 0.13 12.2 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.13 CCF47417.1 - 0.065 13.2 0.0 0.25 11.3 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain HI0933_like PF03486.9 CCF47417.1 - 0.096 11.1 0.0 0.17 10.3 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein Ank PF00023.25 CCF47418.1 - 7.9e-82 265.2 14.3 1.5e-11 43.4 0.0 10.7 11 0 0 11 11 11 10 Ankyrin repeat Ank_2 PF12796.2 CCF47418.1 - 2.7e-78 258.3 0.2 1.4e-20 73.4 0.0 5.8 1 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.1 CCF47418.1 - 1e-59 192.5 0.3 4.1e-08 32.6 0.0 10.4 10 0 0 10 10 10 9 Ankyrin repeat Ank_4 PF13637.1 CCF47418.1 - 1.5e-59 197.4 4.0 4.8e-15 55.6 0.0 7.6 2 2 5 8 8 8 8 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF47418.1 - 2.4e-57 189.6 9.0 2.1e-11 43.6 0.0 9.3 2 1 7 9 9 9 9 Ankyrin repeats (many copies) Pkinase PF00069.20 CCF47418.1 - 5e-50 170.0 0.0 7e-50 169.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF47418.1 - 2.3e-32 112.0 0.0 3.4e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 CCF47418.1 - 0.016 14.3 0.0 0.029 13.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Shigella_OspC PF06128.6 CCF47418.1 - 0.17 11.3 0.0 4.2 6.7 0.0 2.8 3 1 0 3 3 3 0 Shigella flexneri OspC protein MFS_1 PF07690.11 CCF47419.1 - 4.5e-17 61.8 15.5 4.8e-16 58.4 11.9 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF2512 PF10710.4 CCF47419.1 - 0.031 13.7 1.4 7.2 6.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2512) Kelch_3 PF13415.1 CCF47420.1 - 2.4 8.4 5.0 5.4 7.3 1.7 2.8 1 1 1 2 2 2 0 Galactose oxidase, central domain S1FA PF04689.8 CCF47422.1 - 0.084 12.7 0.1 0.37 10.6 0.0 2.1 1 0 0 1 1 1 0 DNA binding protein S1FA Ycf1 PF05758.7 CCF47422.1 - 0.71 7.5 15.0 0.27 8.8 2.5 2.1 2 0 0 2 2 2 0 Ycf1 IU_nuc_hydro PF01156.14 CCF47423.1 - 8.6e-56 189.4 0.0 2.2e-43 148.6 0.0 2.1 2 0 0 2 2 2 2 Inosine-uridine preferring nucleoside hydrolase LSM PF01423.17 CCF47424.1 - 2.3e-14 52.6 0.0 3.2e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 LSM domain Fig1 PF12351.3 CCF47425.1 - 1.5 8.6 8.6 3.6 7.4 6.0 1.6 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 Na_Ca_ex PF01699.19 CCF47426.1 - 0.0011 18.6 1.4 0.0014 18.2 0.9 1.2 1 0 0 1 1 1 1 Sodium/calcium exchanger protein DUF4173 PF13777.1 CCF47426.1 - 0.066 12.4 0.7 0.071 12.4 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4173) DUF202 PF02656.10 CCF47426.1 - 0.12 12.6 0.3 0.18 12.0 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF202) DUF3742 PF12553.3 CCF47426.1 - 0.14 12.6 1.2 0.68 10.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3742) MLANA PF14991.1 CCF47426.1 - 0.79 9.7 2.5 0.44 10.5 0.7 1.5 1 1 0 1 1 1 0 Protein melan-A Y_phosphatase3 PF13350.1 CCF47428.1 - 4.4e-05 23.7 0.0 7.3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3C PF13348.1 CCF47428.1 - 0.0043 17.1 0.0 0.01 15.9 0.0 1.9 1 1 0 1 1 1 1 Tyrosine phosphatase family C-terminal region MCR_C PF04609.7 CCF47430.1 - 0.087 11.6 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C Lig_chan PF00060.21 CCF47430.1 - 5.5 6.7 8.5 1.4 8.6 3.6 1.7 2 0 0 2 2 2 0 Ligand-gated ion channel DUF2011 PF09428.5 CCF47431.1 - 0.0091 15.8 0.0 0.011 15.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2011) Chitin_synth_2 PF03142.10 CCF47434.1 - 2.3e-294 976.6 0.0 3.4e-294 976.1 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.1 CCF47434.1 - 3.5e-18 66.0 4.3 1.6e-17 63.8 3.0 2.1 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 CCF47434.1 - 1.4e-14 54.4 0.0 5.6e-14 52.4 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Cyt-b5 PF00173.23 CCF47434.1 - 3.8e-12 45.8 0.1 2.9e-09 36.6 0.0 2.5 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glyco_transf_21 PF13506.1 CCF47434.1 - 1.2e-05 24.6 0.0 0.00033 19.9 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 CCF47434.1 - 0.01 15.5 0.0 0.04 13.5 0.0 2.0 1 0 0 1 1 1 0 Glycosyl transferase family 2 DUF2207 PF09972.4 CCF47434.1 - 3.5 6.1 5.0 32 2.9 1.5 2.9 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) U1snRNP70_N PF12220.3 CCF47435.1 - 1.5 9.2 6.5 6.2 7.2 0.5 2.6 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal ARF7EP_C PF14949.1 CCF47435.1 - 1.6 9.1 8.4 0.18 12.2 1.6 2.1 2 0 0 2 2 2 0 ARF7 effector protein C-terminus Herpes_capsid PF06112.6 CCF47435.1 - 2 8.4 8.3 0.21 11.6 1.5 2.2 1 1 0 2 2 2 0 Gammaherpesvirus capsid protein Phe_hydrox_dim PF07976.7 CCF47436.1 - 1.4e-05 24.8 0.0 1.7e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Peptidase_S8 PF00082.17 CCF47437.1 - 8.4e-22 77.6 0.1 1e-21 77.3 0.1 1.1 1 0 0 1 1 1 1 Subtilase family RVT_1 PF00078.22 CCF47438.1 - 9.2e-11 41.4 0.0 1.4e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.19 CCF47439.1 - 1.5e-11 44.7 0.5 1.1e-07 32.1 0.1 2.1 1 1 1 2 2 2 2 RNase H DDE_1 PF03184.14 CCF47441.1 - 1.1e-20 73.7 0.0 1.4e-20 73.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.11 CCF47441.1 - 2.3e-08 33.4 0.2 5.9e-08 32.1 0.1 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 CCF47441.1 - 1.2e-05 24.9 0.0 3.4e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_AsnC-type PF13404.1 CCF47441.1 - 0.015 14.7 0.1 0.039 13.4 0.0 1.6 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain Acyl-CoA_dh_N PF02771.11 CCF47442.1 - 3.1e-22 79.2 0.0 6.4e-22 78.2 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.19 CCF47442.1 - 5.6e-20 71.9 1.0 8.7e-20 71.3 0.7 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 CCF47442.1 - 2.7e-19 68.4 1.4 2.7e-19 68.4 1.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain SIS PF01380.17 CCF47443.1 - 0.091 12.3 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 SIS domain MutS_V PF00488.16 CCF47445.1 - 6.5e-13 48.6 0.1 4.4e-12 45.9 0.0 1.9 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.13 CCF47445.1 - 2.2e-06 27.5 0.2 3.2e-06 27.0 0.1 1.2 1 0 0 1 1 1 1 MutS domain III AAA_21 PF13304.1 CCF47445.1 - 0.0015 18.5 0.2 0.0041 17.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.1 CCF47445.1 - 0.0015 18.8 0.6 0.0039 17.5 0.1 1.7 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 CCF47445.1 - 0.0038 16.7 0.1 0.0063 16.0 0.1 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.22 CCF47445.1 - 0.018 15.3 0.4 0.14 12.4 0.3 2.0 1 1 1 2 2 2 0 ABC transporter AAA_15 PF13175.1 CCF47445.1 - 0.076 12.0 0.0 0.18 10.8 0.0 1.5 1 1 0 2 2 2 0 AAA ATPase domain Fungal_trans_2 PF11951.3 CCF47446.1 - 6e-30 104.1 0.0 7.6e-30 103.7 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ank_2 PF12796.2 CCF47447.1 - 9.5e-54 179.7 1.2 1e-17 64.2 0.2 4.4 3 2 1 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 CCF47447.1 - 1.7e-46 153.7 15.9 3.5e-06 26.5 0.3 10.7 10 1 1 11 11 11 8 Ankyrin repeat Ank_4 PF13637.1 CCF47447.1 - 6.4e-35 118.9 2.1 2.5e-08 34.2 0.0 7.4 3 3 4 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF47447.1 - 4.9e-31 103.6 3.4 0.0039 17.3 0.0 9.5 9 0 0 9 9 9 9 Ankyrin repeat Ank_5 PF13857.1 CCF47447.1 - 2.7e-28 97.3 7.6 5.9e-06 26.3 0.0 7.9 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Nitro_FeMo-Co PF02579.12 CCF47447.1 - 0.019 15.0 1.8 3.7 7.6 0.0 4.2 2 1 4 6 6 6 0 Dinitrogenase iron-molybdenum cofactor Rotamase_3 PF13616.1 CCF47447.1 - 0.087 13.0 0.1 3.6 7.8 0.0 2.4 2 0 0 2 2 2 0 PPIC-type PPIASE domain Yippee-Mis18 PF03226.9 CCF47448.1 - 0.027 14.5 0.1 0.032 14.2 0.0 1.1 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF3268 PF11672.3 CCF47448.1 - 0.12 12.4 0.2 0.13 12.3 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3268) Evr1_Alr PF04777.8 CCF47448.1 - 0.13 12.1 0.1 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 Erv1 / Alr family Ferric_reduct PF01794.14 CCF47449.1 - 2.2e-20 72.9 7.1 5.7e-20 71.6 4.9 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.7 CCF47449.1 - 3.5e-19 69.2 0.0 1.9e-16 60.3 0.0 2.4 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 CCF47449.1 - 6.3e-15 54.9 0.0 1.8e-14 53.4 0.0 1.8 1 1 0 1 1 1 1 FAD-binding domain DUF1345 PF07077.6 CCF47449.1 - 0.082 12.4 5.0 0.068 12.6 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) Arf PF00025.16 CCF47454.1 - 6.5e-75 250.1 0.1 7.5e-75 249.9 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 CCF47454.1 - 1.9e-12 46.8 0.0 2.1e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 CCF47454.1 - 4.7e-12 45.3 2.7 6.5e-09 34.9 0.3 2.2 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.5 CCF47454.1 - 7.4e-12 44.8 0.0 9.2e-12 44.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 CCF47454.1 - 9.4e-11 41.2 0.0 1.1e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 CCF47454.1 - 2.9e-08 34.2 0.0 4e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 CCF47454.1 - 0.00044 20.1 0.0 0.00056 19.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.13 CCF47454.1 - 0.045 12.8 0.1 0.072 12.1 0.1 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase NdhL PF10716.4 CCF47455.1 - 0.036 13.8 0.1 0.048 13.4 0.1 1.2 1 0 0 1 1 1 0 NADH dehydrogenase transmembrane subunit WD40 PF00400.27 CCF47458.1 - 3e-29 99.7 9.7 6.2e-08 32.2 0.1 4.8 4 0 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.3 CCF47458.1 - 0.0052 14.9 1.9 1.3 7.0 0.0 3.0 3 1 1 4 4 4 2 Nucleoporin Nup120/160 PQQ_2 PF13360.1 CCF47458.1 - 0.065 12.6 1.4 6.8 6.0 0.1 3.0 4 1 0 4 4 4 0 PQQ-like domain eIF2A PF08662.6 CCF47458.1 - 0.072 12.7 0.0 18 5.0 0.0 2.6 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A RNB PF00773.14 CCF47458.1 - 0.084 12.1 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 RNB domain TSNR_N PF04705.7 CCF47458.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Thiostrepton-resistance methylase, N terminus PQQ_3 PF13570.1 CCF47458.1 - 3.9 7.8 6.4 8.5 6.8 0.0 3.9 4 0 0 4 4 4 0 PQQ-like domain LNS2 PF08235.8 CCF47460.1 - 0.00071 19.1 0.1 0.0013 18.3 0.1 1.4 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Baculo_PP31 PF05311.6 CCF47462.1 - 0.16 11.2 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Git3 PF11710.3 CCF47463.1 - 7e-10 38.7 1.7 8.4e-10 38.5 1.2 1.0 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_2 PF00002.19 CCF47463.1 - 0.031 13.3 1.2 0.036 13.1 0.8 1.0 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) Vma12 PF11712.3 CCF47463.1 - 0.4 10.3 4.1 0.65 9.6 2.9 1.6 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase APH_6_hur PF04655.9 CCF47464.1 - 0.087 11.9 0.4 0.11 11.6 0.3 1.1 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Cucumo_coat PF00760.13 CCF47464.1 - 0.12 11.3 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 Cucumovirus coat protein GCS PF03074.11 CCF47465.1 - 3.7e-98 328.9 0.0 4.4e-98 328.7 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase AA_permease_2 PF13520.1 CCF47466.1 - 1e-37 129.7 19.0 1.3e-37 129.3 13.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CCF47466.1 - 2.1e-17 62.6 18.1 2.6e-17 62.3 12.5 1.0 1 0 0 1 1 1 1 Amino acid permease HgmA PF04209.8 CCF47467.1 - 9.7e-183 607.3 0.0 1.1e-182 607.1 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase FAA_hydrolase PF01557.13 CCF47468.1 - 5.4e-53 179.6 0.0 7.2e-53 179.2 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.6 CCF47468.1 - 2.2e-22 79.0 0.0 4e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal Dabb PF07876.7 CCF47469.1 - 3.9e-15 56.0 0.0 4.8e-15 55.7 0.0 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain AMP-binding_C PF13193.1 CCF47470.1 - 2.9e-09 37.7 0.0 3.6e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PRMT5 PF05185.11 CCF47470.1 - 0.094 11.6 0.0 0.096 11.5 0.0 1.0 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase E3_binding PF02817.12 CCF47471.1 - 0.023 14.3 0.4 0.042 13.4 0.2 1.4 1 0 0 1 1 1 0 e3 binding domain DUF1524 PF07510.6 CCF47472.1 - 1.3e-15 57.5 0.0 1.7e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1524) HNH_4 PF13395.1 CCF47472.1 - 0.13 11.9 0.0 8.4 6.1 0.0 2.2 2 0 0 2 2 2 0 HNH endonuclease Herpes_UL56 PF04534.7 CCF47473.1 - 0.047 13.3 0.7 0.059 13.0 0.5 1.1 1 0 0 1 1 1 0 Herpesvirus UL56 protein Period_C PF12114.3 CCF47475.1 - 7.5 6.1 10.1 8 6.0 7.0 1.0 1 0 0 1 1 1 0 Period protein 2/3C-terminal region RRM_1 PF00076.17 CCF47477.1 - 2e-13 49.7 0.0 4.8e-13 48.5 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF47477.1 - 3.7e-11 42.8 0.0 6.4e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF47477.1 - 2.6e-05 23.9 0.0 7.6e-05 22.4 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GTP_EFTU PF00009.22 CCF47478.1 - 2.3e-54 183.6 0.0 3.8e-54 182.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.20 CCF47478.1 - 1.5e-06 28.2 0.0 3e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 CCF47478.1 - 0.0055 16.6 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Paf67 PF10255.4 CCF47479.1 - 9.7e-153 508.8 0.8 1.2e-152 508.5 0.6 1.1 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.12 CCF47479.1 - 0.016 15.1 0.0 0.088 12.7 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 CCF47479.1 - 0.057 13.0 0.0 0.29 10.8 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 CCF47479.1 - 0.063 13.2 0.0 0.5 10.3 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat MFS_1 PF07690.11 CCF47481.1 - 0.00015 20.5 30.2 0.00028 19.7 21.0 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily RskA PF10099.4 CCF47482.1 - 0.31 10.7 2.1 0.55 9.9 1.4 1.4 1 0 0 1 1 1 0 Anti-sigma-K factor rskA GHMP_kinases_N PF00288.21 CCF47485.1 - 4.8e-11 42.5 2.5 3.5e-10 39.7 0.5 2.5 2 0 0 2 2 2 1 GHMP kinases N terminal domain DUF647 PF04884.9 CCF47486.1 - 6.6e-89 297.4 1.6 8.6e-89 297.0 0.5 1.6 2 0 0 2 2 2 1 Vitamin B6 photo-protection and homoeostasis ISK_Channel PF02060.10 CCF47486.1 - 0.072 12.6 0.0 0.5 9.9 0.0 2.1 2 0 0 2 2 2 0 Slow voltage-gated potassium channel IL12p40_C PF10420.4 CCF47486.1 - 0.094 12.8 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Cytokine interleukin-12p40 C-terminus GPI-anchored PF10342.4 CCF47487.1 - 0.026 14.9 0.3 0.044 14.2 0.2 1.6 1 1 0 1 1 1 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family CBM_2 PF00553.14 CCF47487.1 - 0.045 13.7 0.3 0.065 13.2 0.2 1.3 1 0 0 1 1 1 0 Cellulose binding domain DHQ_synthase PF01761.15 CCF47489.1 - 1.9e-39 135.1 0.0 2.7e-39 134.6 0.0 1.1 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.1 CCF47489.1 - 0.00031 20.1 0.0 0.00054 19.3 0.0 1.4 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DUF836 PF05768.9 CCF47490.1 - 7.4e-12 45.3 0.0 8.7e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.19 CCF47490.1 - 0.00084 19.2 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin AMP-binding_C PF13193.1 CCF47491.1 - 4.3e-20 72.4 0.2 5.1e-20 72.1 0.2 1.1 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain TPR_11 PF13414.1 CCF47493.1 - 0.034 13.7 0.4 12 5.6 0.1 2.8 2 0 0 2 2 2 0 TPR repeat Glyco_hydro_16 PF00722.16 CCF47494.1 - 6.3e-43 146.2 1.7 6.3e-43 146.2 1.2 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 DUF1080 PF06439.6 CCF47494.1 - 0.023 14.5 0.1 0.036 13.9 0.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) MARVEL PF01284.18 CCF47496.1 - 0.0034 17.1 1.4 0.0061 16.3 1.0 1.4 1 1 0 1 1 1 1 Membrane-associating domain DUF4231 PF14015.1 CCF47496.1 - 0.0048 16.8 1.9 0.085 12.8 1.4 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF4231) DUF1206 PF06724.6 CCF47496.1 - 0.019 14.6 0.4 3.1 7.6 0.0 2.9 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1206) UPF0104 PF03706.8 CCF47496.1 - 0.043 13.0 4.2 0.057 12.6 2.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0104) DUF1218 PF06749.7 CCF47496.1 - 0.19 12.1 1.5 0.43 11.0 0.4 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF1218) Apq12 PF12716.2 CCF47496.1 - 1.9 8.2 10.1 0.18 11.5 3.7 1.8 2 0 0 2 2 2 0 Nuclear pore assembly and biogenesis Abhydrolase_2 PF02230.11 CCF47497.1 - 1.2e-24 87.0 0.0 3.2e-15 56.1 0.0 2.7 2 1 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 CCF47497.1 - 2.4e-05 24.3 0.6 9.4e-05 22.3 0.4 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF47497.1 - 6e-05 22.8 0.0 0.00018 21.3 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CCF47497.1 - 8.8e-05 21.8 0.0 0.00035 19.8 0.0 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family FSH1 PF03959.8 CCF47497.1 - 0.003 17.0 0.0 0.023 14.1 0.0 2.2 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Sec15 PF04091.7 CCF47499.1 - 1.4e-45 155.9 0.4 1.6e-45 155.7 0.3 1.0 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like DIL PF01843.14 CCF47499.1 - 0.041 13.7 0.0 0.054 13.3 0.0 1.2 1 0 0 1 1 1 0 DIL domain DUF1704 PF08014.6 CCF47499.1 - 0.081 11.9 0.0 0.095 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1704) Rbsn PF11464.3 CCF47499.1 - 0.089 12.3 0.7 0.17 11.4 0.5 1.5 1 0 0 1 1 1 0 Rabenosyn Rab binding domain Geminin PF07412.7 CCF47499.1 - 0.15 11.7 0.4 0.2 11.3 0.3 1.2 1 0 0 1 1 1 0 Geminin Oxidored_q6 PF01058.17 CCF47500.1 - 1.2e-22 79.8 0.1 1.8e-22 79.3 0.0 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit adh_short_C2 PF13561.1 CCF47501.1 - 3.6e-10 40.0 0.0 4.3e-10 39.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 CCF47503.1 - 2.8e-05 23.6 0.0 5.1e-05 22.8 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Bac_rhamnosid PF05592.6 CCF47505.1 - 0.00067 18.0 0.0 0.00069 17.9 0.0 1.0 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase UPF0160 PF03690.8 CCF47506.1 - 1e-10 41.6 0.2 1.2e-10 41.3 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Ino80_Iec3 PF14612.1 CCF47507.1 - 1.3e-18 67.9 2.6 1.5e-18 67.6 1.8 1.1 1 0 0 1 1 1 1 IEC3 subunit of the Ino80 complex, chromatin re-modelling GrpE PF01025.14 CCF47507.1 - 0.013 15.0 0.8 0.016 14.7 0.5 1.1 1 0 0 1 1 1 0 GrpE Tox-REase-5 PF15648.1 CCF47507.1 - 0.014 15.6 0.1 0.016 15.4 0.1 1.0 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 5 DUF3007 PF11460.3 CCF47507.1 - 0.14 12.2 0.2 0.18 11.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3007) RasGEF PF00617.14 CCF47508.1 - 4.4e-50 170.0 0.1 7e-50 169.3 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain Miro PF08477.8 CCF47508.1 - 9.5e-16 58.3 0.0 4.6e-15 56.1 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein RasGEF_N PF00618.15 CCF47508.1 - 1.5e-13 50.7 0.0 3.4e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif Ras PF00071.17 CCF47508.1 - 4.1e-07 29.5 1.6 7.5e-05 22.1 0.0 2.8 3 0 0 3 3 3 2 Ras family FtsK_SpoIIIE PF01580.13 CCF47508.1 - 0.001 18.6 0.0 0.016 14.6 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_22 PF13401.1 CCF47508.1 - 0.0025 17.9 0.2 0.31 11.1 0.0 2.8 2 1 0 2 2 2 1 AAA domain GTP_EFTU PF00009.22 CCF47508.1 - 0.0034 16.8 0.0 0.12 11.8 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 CCF47508.1 - 0.016 15.2 0.0 0.068 13.1 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.1 CCF47508.1 - 0.017 15.8 0.1 0.26 12.0 0.0 3.0 3 0 0 3 3 3 0 AAA domain DUF258 PF03193.11 CCF47508.1 - 0.066 12.4 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ATP_bind_1 PF03029.12 CCF47508.1 - 0.09 12.2 0.1 8.6 5.8 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.18 CCF47508.1 - 0.092 12.7 0.2 0.59 10.1 0.2 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase IIGP PF05049.8 CCF47508.1 - 0.15 10.8 1.8 0.1 11.3 0.1 1.6 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) F_bP_aldolase PF01116.15 CCF47511.1 - 1.9e-47 161.7 0.1 2.1e-47 161.6 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Sec7 PF01369.15 CCF47513.1 - 2.2e-38 131.8 0.0 3.6e-38 131.1 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Peptidase_M14 PF00246.19 CCF47514.1 - 2.1e-64 217.8 0.0 2.8e-64 217.4 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase MAPEG PF01124.13 CCF47515.1 - 6.3e-22 77.5 1.3 7.6e-22 77.3 0.9 1.1 1 0 0 1 1 1 1 MAPEG family DNA_pol_B_thumb PF14791.1 CCF47516.1 - 2.1e-21 75.3 0.0 3.6e-21 74.6 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_B_palm PF14792.1 CCF47516.1 - 1.4e-17 63.7 0.1 3.2e-17 62.6 0.1 1.5 1 1 0 1 1 1 1 DNA polymerase beta palm NTP_transf_2 PF01909.18 CCF47516.1 - 0.00022 21.4 0.1 0.00064 20.0 0.1 1.8 1 1 0 1 1 1 1 Nucleotidyltransferase domain Oxidored_FMN PF00724.15 CCF47517.1 - 0.0038 16.2 0.0 0.0047 15.9 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Patched PF02460.13 CCF47518.1 - 5.3e-27 94.1 11.4 6.1e-27 93.9 7.9 1.0 1 0 0 1 1 1 1 Patched family ACR_tran PF00873.14 CCF47518.1 - 0.00079 16.9 11.2 0.00079 16.9 7.8 1.5 2 0 0 2 2 2 1 AcrB/AcrD/AcrF family MMPL PF03176.10 CCF47518.1 - 0.0037 16.0 13.6 0.0053 15.5 9.4 1.2 1 0 0 1 1 1 1 MMPL family DUF1700 PF08006.6 CCF47518.1 - 1.5 8.0 13.4 0.16 11.2 3.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Herpes_U47 PF05467.6 CCF47519.1 - 0.53 8.0 2.8 0.56 7.9 2.0 1.0 1 0 0 1 1 1 0 Herpesvirus glycoprotein U47 A_deaminase PF00962.17 CCF47521.1 - 2.2e-14 53.1 0.0 2.6e-14 52.8 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase DUF2638 PF10937.3 CCF47522.1 - 1.2e-34 119.6 1.3 1.5e-34 119.3 0.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2638) Nop14 PF04147.7 CCF47523.1 - 0.49 8.2 41.3 0.65 7.8 28.6 1.1 1 0 0 1 1 1 0 Nop14-like family Lectin_N PF03954.9 CCF47524.1 - 0.0036 16.7 0.0 0.0049 16.2 0.0 1.2 1 0 0 1 1 1 1 Hepatic lectin, N-terminal domain IBR PF01485.16 CCF47525.1 - 1e-09 38.1 36.1 1e-06 28.5 9.9 3.4 3 0 0 3 3 3 2 IBR domain FAA_hydrolase PF01557.13 CCF47526.1 - 1.9e-60 204.0 0.0 2.6e-60 203.5 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Complex1_LYR PF05347.10 CCF47527.1 - 7.6e-15 54.4 1.5 9.1e-15 54.2 1.0 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 CCF47527.1 - 8.8e-14 51.4 1.5 1.1e-13 51.2 1.0 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_2 PF13233.1 CCF47527.1 - 0.055 13.9 0.1 0.071 13.5 0.1 1.2 1 0 0 1 1 1 0 Complex1_LYR-like RRM_1 PF00076.17 CCF47532.1 - 1.1e-11 44.1 0.0 1.9e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF47532.1 - 2.2e-09 37.1 0.0 4.8e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF47532.1 - 3.5e-08 33.1 0.0 6e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 PF10243.4 CCF47532.1 - 0.008 14.6 2.1 0.015 13.7 1.5 1.4 1 1 0 1 1 1 1 Microtubule-binding protein MIP-T3 RRM_3 PF08777.6 CCF47532.1 - 0.023 14.5 0.1 0.041 13.7 0.1 1.4 1 0 0 1 1 1 0 RNA binding motif Ribonuc_L-PSP PF01042.16 CCF47533.1 - 3.6e-35 120.3 0.0 4.1e-35 120.1 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP NACHT PF05729.7 CCF47534.1 - 2.5e-08 33.7 0.1 6.5e-08 32.4 0.1 1.6 1 0 0 1 1 1 1 NACHT domain PNP_UDP_1 PF01048.15 CCF47534.1 - 6.7e-08 31.7 0.0 1.4e-07 30.7 0.0 1.5 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_22 PF13401.1 CCF47534.1 - 4.8e-07 29.9 0.1 5e-05 23.4 0.0 3.0 2 1 1 3 3 3 1 AAA domain AAA PF00004.24 CCF47534.1 - 0.00045 20.4 1.6 0.004 17.3 1.1 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF47534.1 - 0.001 19.0 0.0 0.0052 16.7 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 CCF47534.1 - 0.0025 18.6 0.1 0.012 16.3 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 CCF47534.1 - 0.02 14.2 0.0 0.046 13.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 CCF47534.1 - 0.025 14.8 0.0 0.05 13.8 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_11 PF13086.1 CCF47534.1 - 0.059 12.9 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 CCF47534.1 - 0.06 13.5 0.1 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_10 PF12846.2 CCF47534.1 - 0.089 12.2 1.9 0.32 10.3 0.3 2.1 2 0 0 2 2 2 0 AAA-like domain NTPase_1 PF03266.10 CCF47534.1 - 0.1 12.3 0.1 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 NTPase AAA_18 PF13238.1 CCF47534.1 - 0.1 12.8 0.1 0.1 12.8 0.1 2.7 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.1 CCF47534.1 - 0.15 11.6 0.0 0.32 10.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.1 CCF47534.1 - 0.93 9.7 9.0 70 3.6 5.9 2.8 2 1 0 2 2 2 0 AAA domain Ank_2 PF12796.2 CCF47535.1 - 1.3e-13 51.0 0.3 1.2e-12 47.9 0.2 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 CCF47535.1 - 6e-12 44.7 0.3 0.00067 19.3 0.0 3.2 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 CCF47535.1 - 2.3e-11 43.8 1.1 2.1e-05 24.8 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 CCF47535.1 - 5.3e-10 39.2 1.7 2e-08 34.1 1.0 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 CCF47535.1 - 2.4e-06 27.2 0.2 0.018 15.2 0.1 3.3 3 0 0 3 3 3 1 Ankyrin repeat PAP2 PF01569.16 CCF47537.1 - 1.3e-11 44.3 0.1 1.3e-11 44.3 0.1 2.0 2 0 0 2 2 2 1 PAP2 superfamily FMN_red PF03358.10 CCF47538.1 - 0.068 12.6 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 NADPH-dependent FMN reductase DUF4452 PF14618.1 CCF47539.1 - 2.1e-80 268.3 11.6 2.6e-80 268.0 8.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4452) HTH_Tnp_Tc5 PF03221.11 CCF47544.1 - 0.042 13.6 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain MFS_1 PF07690.11 CCF47545.1 - 6.1e-25 87.6 26.6 7.4e-25 87.4 18.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Phage_holin_5 PF06946.6 CCF47545.1 - 0.33 11.1 0.1 0.33 11.1 0.1 2.1 2 0 0 2 2 2 0 Phage holin CDC27 PF09507.5 CCF47546.1 - 5.7 6.0 5.9 7.6 5.6 4.1 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Synaptobrevin PF00957.16 CCF47549.1 - 0.14 11.8 0.1 0.15 11.6 0.1 1.1 1 0 0 1 1 1 0 Synaptobrevin Vps55 PF04133.9 CCF47550.1 - 6.8e-47 158.1 6.3 7.5e-47 158.0 4.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF2721 PF11026.3 CCF47550.1 - 8.9 5.9 8.3 0.96 9.0 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) LVIVD PF08309.6 CCF47552.1 - 0.063 12.2 0.1 1.6 7.8 0.0 2.8 2 0 0 2 2 2 0 LVIVD repeat PP1_bind PF15276.1 CCF47554.1 - 0.016 15.1 14.4 0.86 9.6 1.1 3.3 1 1 2 3 3 3 0 Protein phosphatase 1 binding K_channel_TID PF07941.6 CCF47554.1 - 2.3 8.5 7.2 0.41 10.8 1.5 2.1 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Spo12 PF05032.7 CCF47555.1 - 1.4e-14 53.4 0.5 1.4e-14 53.4 0.4 2.1 2 0 0 2 2 2 1 Spo12 family Peptidase_M24 PF00557.19 CCF47556.1 - 3.2e-11 43.1 0.0 3.8e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Methyltransf_23 PF13489.1 CCF47560.1 - 0.0029 17.3 0.0 0.0045 16.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.13 CCF47560.1 - 0.05 12.8 0.0 0.078 12.2 0.0 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Abhydrolase_5 PF12695.2 CCF47562.1 - 1.2e-07 31.6 0.1 2.6e-07 30.4 0.1 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 CCF47562.1 - 0.00055 19.5 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.2 CCF47562.1 - 0.00056 19.8 0.3 0.0019 18.1 0.1 1.8 1 1 0 2 2 2 1 Alpha/beta hydrolase family DUF676 PF05057.9 CCF47562.1 - 0.00089 18.6 0.0 0.0019 17.5 0.0 1.6 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_2 PF02230.11 CCF47562.1 - 0.027 13.9 0.0 0.068 12.6 0.0 1.6 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Esterase PF00756.15 CCF47562.1 - 0.029 13.7 0.0 0.073 12.4 0.0 1.6 2 0 0 2 2 2 0 Putative esterase Thioesterase PF00975.15 CCF47562.1 - 0.031 14.4 0.0 0.051 13.7 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_3 PF07859.8 CCF47562.1 - 0.049 13.2 0.0 0.067 12.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.20 CCF47562.1 - 0.13 11.8 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) UDPG_MGDP_dh_N PF03721.9 CCF47563.1 - 2.7e-19 69.2 1.4 2.9e-16 59.4 1.0 2.1 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.10 CCF47563.1 - 1.1e-06 28.5 0.0 1.5e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase TrkA_N PF02254.13 CCF47563.1 - 0.0013 18.7 0.0 0.0021 18.0 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain Saccharop_dh PF03435.13 CCF47563.1 - 0.0054 15.7 0.1 1 8.2 0.0 2.0 2 0 0 2 2 2 2 Saccharopine dehydrogenase Methyltransf_18 PF12847.2 CCF47563.1 - 0.01 16.3 0.0 0.019 15.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain 3HCDH_N PF02737.13 CCF47563.1 - 0.03 13.9 0.0 0.037 13.6 0.0 1.3 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1685 PF07939.6 CCF47565.1 - 0.11 12.1 0.4 1.5 8.5 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1685) PKD_channel PF08016.7 CCF47567.1 - 1.1 7.6 9.3 3.6 5.9 0.3 2.2 2 0 0 2 2 2 0 Polycystin cation channel DUF1961 PF09224.6 CCF47568.1 - 6.4e-80 267.3 0.0 7.5e-80 267.1 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1961) DUF1080 PF06439.6 CCF47568.1 - 0.017 14.9 0.0 0.02 14.7 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) Peroxidase_2 PF01328.12 CCF47569.1 - 1.3e-36 125.8 0.1 1.6e-36 125.5 0.1 1.0 1 0 0 1 1 1 1 Peroxidase, family 2 HMG-CoA_red PF00368.13 CCF47574.1 - 3.3e-128 427.4 8.9 3.8e-128 427.2 6.1 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Complex1_51K PF01512.12 CCF47574.1 - 0.079 12.6 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Respiratory-chain NADH dehydrogenase 51 Kd subunit Anoctamin PF04547.7 CCF47575.1 - 9.7e-102 340.9 1.8 1.1e-101 340.7 1.3 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel Peptidase_M35 PF02102.10 CCF47576.1 - 5.3e-61 206.2 1.0 6.4e-61 205.9 0.7 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.1 CCF47576.1 - 8e-05 23.1 0.5 0.00013 22.4 0.0 1.5 2 0 0 2 2 2 1 Lysine-specific metallo-endopeptidase DUF3762 PF12591.3 CCF47576.1 - 0.085 12.9 0.6 0.19 11.8 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3762) Ribonuc_2-5A PF06479.7 CCF47578.1 - 9.8e-44 148.3 0.0 1.9e-43 147.3 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.20 CCF47578.1 - 3.5e-41 141.0 0.0 5.7e-41 140.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF47578.1 - 7e-20 71.1 0.0 5.5e-19 68.2 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 CCF47578.1 - 0.0011 18.1 0.0 0.0033 16.5 0.0 1.8 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CCF47578.1 - 0.025 14.3 5.1 0.052 13.2 0.1 2.7 2 1 0 2 2 2 0 Phosphotransferase enzyme family PQQ PF01011.16 CCF47578.1 - 0.028 13.9 0.2 7.8 6.2 0.1 2.9 2 0 0 2 2 2 0 PQQ enzyme repeat YrbL-PhoP_reg PF10707.4 CCF47578.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Fasciclin PF02469.17 CCF47579.1 - 1.4e-10 41.3 1.7 1.4e-10 41.3 1.2 1.5 1 1 1 2 2 2 1 Fasciclin domain UBX PF00789.15 CCF47580.1 - 1.5e-11 44.1 0.0 2.2e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 UBX domain BMP2K_C PF15282.1 CCF47580.1 - 0.13 12.3 0.3 0.26 11.4 0.0 1.5 2 0 0 2 2 2 0 BMP-2-inducible protein kinase C-terminus CHCH PF06747.8 CCF47581.1 - 0.00021 21.1 5.0 0.00031 20.5 3.4 1.3 1 0 0 1 1 1 1 CHCH domain DUF2076 PF09849.4 CCF47581.1 - 0.00026 21.1 0.7 0.00031 20.8 0.5 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) GCK PF07802.6 CCF47581.1 - 0.02 14.9 0.4 0.061 13.4 0.1 1.8 1 1 1 2 2 2 0 GCK domain Romo1 PF10247.4 CCF47581.1 - 0.058 13.5 0.1 0.091 12.9 0.1 1.3 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 DUF1517 PF07466.6 CCF47581.1 - 0.15 10.9 0.9 0.17 10.8 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) COX6B PF02297.12 CCF47581.1 - 0.18 11.8 2.4 0.28 11.2 1.7 1.3 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb COX17 PF05051.8 CCF47581.1 - 0.76 9.8 2.7 1.2 9.1 0.2 2.0 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) Atrophin-1 PF03154.10 CCF47582.1 - 2.2 6.3 5.1 2.1 6.4 3.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family p450 PF00067.17 CCF47585.1 - 7.7e-37 126.8 0.0 8.5e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NmrA PF05368.8 CCF47586.1 - 1.7e-14 53.6 0.0 2.4e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 CCF47586.1 - 6.7e-13 49.0 0.0 9.2e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CCF47586.1 - 3e-05 23.5 0.1 4.4e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.15 CCF47586.1 - 0.00018 21.4 0.5 0.00052 19.9 0.4 1.8 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.20 CCF47586.1 - 0.029 14.3 0.7 0.079 12.8 0.2 1.9 2 0 0 2 2 2 0 short chain dehydrogenase KR PF08659.5 CCF47586.1 - 0.11 12.1 0.2 0.21 11.2 0.1 1.5 1 1 0 1 1 1 0 KR domain 3Beta_HSD PF01073.14 CCF47586.1 - 0.14 10.8 0.1 0.2 10.2 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Methyltransf_23 PF13489.1 CCF47587.1 - 2.5e-21 76.0 0.0 4.4e-21 75.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF47587.1 - 3.7e-11 42.8 0.0 6.5e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF47587.1 - 5.8e-11 42.9 0.0 3.7e-10 40.3 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF47587.1 - 1.6e-08 34.9 0.0 3.3e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF47587.1 - 1.1e-07 32.2 0.0 4.2e-07 30.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF47587.1 - 5.3e-07 29.9 0.0 2.1e-06 28.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF47587.1 - 0.00031 19.8 0.0 0.0048 15.9 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_16 PF10294.4 CCF47587.1 - 0.017 14.5 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase MTS PF05175.9 CCF47587.1 - 0.019 14.3 0.0 0.043 13.1 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_26 PF13659.1 CCF47587.1 - 0.041 13.9 0.0 0.28 11.2 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain PIN_4 PF13638.1 CCF47587.1 - 0.079 13.0 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 PIN domain Aldo_ket_red PF00248.16 CCF47588.1 - 1.6e-44 151.8 0.0 2.2e-44 151.3 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family eRF1_1 PF03463.10 CCF47589.1 - 6.1e-41 139.0 0.1 1.5e-40 137.8 0.0 1.7 2 0 0 2 2 2 1 eRF1 domain 1 eRF1_2 PF03464.10 CCF47589.1 - 5.3e-22 78.5 0.1 8e-22 77.9 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 CCF47589.1 - 1.3e-16 60.8 0.0 2.4e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 3 WD40 PF00400.27 CCF47590.1 - 2.6e-33 112.6 17.9 1.6e-10 40.4 0.2 7.8 8 0 0 8 8 8 6 WD domain, G-beta repeat IKI3 PF04762.7 CCF47590.1 - 0.03 12.1 0.0 3.3 5.4 0.0 2.2 1 1 1 2 2 2 0 IKI3 family Dicty_REP PF05086.7 CCF47590.1 - 1.2 6.7 7.0 0.27 8.9 2.5 1.5 1 1 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Thioredoxin PF00085.15 CCF47591.1 - 1.7e-23 82.2 0.0 2.8e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 CCF47591.1 - 1.2e-06 28.5 0.0 1.8e-05 24.8 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 CCF47591.1 - 4.5e-05 23.5 3.2 0.00024 21.2 0.3 2.7 1 1 1 2 2 2 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 CCF47591.1 - 0.00051 20.0 0.0 0.00051 20.0 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.16 CCF47591.1 - 0.003 17.2 0.7 0.21 11.2 0.1 2.3 1 1 1 2 2 2 1 AhpC/TSA family Redoxin PF08534.5 CCF47591.1 - 0.0086 15.6 0.7 0.12 11.9 0.2 2.1 1 1 1 2 2 2 1 Redoxin TraF PF13728.1 CCF47591.1 - 0.06 12.8 0.8 0.15 11.5 0.0 1.9 2 0 0 2 2 2 0 F plasmid transfer operon protein HyaE PF07449.6 CCF47591.1 - 0.086 12.7 0.1 0.19 11.6 0.0 1.6 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Amidoligase_2 PF12224.3 CCF47592.1 - 3.1e-15 56.4 0.0 2.6e-12 46.8 0.0 2.3 1 1 1 2 2 2 2 Putative amidoligase enzyme IDO PF01231.13 CCF47593.1 - 8.1e-79 265.0 0.0 9e-79 264.8 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase DUF1864 PF08933.6 CCF47593.1 - 0.0015 17.1 0.0 0.0025 16.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1864) zf-C2H2_4 PF13894.1 CCF47596.1 - 5.3 7.6 15.0 3.6 8.1 0.7 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger Methyltransf_23 PF13489.1 CCF47597.1 - 2.7e-22 79.1 0.0 1.2e-21 77.1 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CCF47597.1 - 1.2e-09 37.9 0.0 1e-08 34.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF47597.1 - 1.3e-09 38.4 0.0 2.2e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF47597.1 - 4.2e-08 33.7 0.0 7.4e-07 29.7 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF47597.1 - 7.5e-06 26.3 0.0 8e-05 23.0 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CCF47597.1 - 0.0001 22.6 0.0 0.00024 21.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CCF47597.1 - 0.00027 20.3 0.0 0.00053 19.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 CCF47597.1 - 0.0034 16.5 0.0 0.0054 15.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 CCF47597.1 - 0.0053 16.7 0.0 0.014 15.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CCF47597.1 - 0.032 13.2 0.0 0.14 11.1 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase DUF938 PF06080.7 CCF47597.1 - 0.055 13.0 0.0 0.085 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Ubie_methyltran PF01209.13 CCF47597.1 - 0.061 12.4 0.0 0.65 9.0 0.0 2.2 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family CMAS PF02353.15 CCF47597.1 - 0.077 12.0 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.4 CCF47597.1 - 0.11 12.0 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase FtsJ PF01728.14 CCF47597.1 - 0.17 11.8 0.0 0.31 10.9 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Chitin_bind_1 PF00187.14 CCF47599.1 - 2.2e-13 49.9 56.3 7.2e-07 29.0 18.8 2.9 2 0 0 2 2 2 2 Chitin recognition protein ABC_tran PF00005.22 CCF47600.1 - 5e-08 33.3 0.1 2.3e-07 31.1 0.0 1.9 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.14 CCF47600.1 - 0.027 13.6 0.0 0.046 12.9 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ABC2_membrane PF01061.19 CCF47600.1 - 0.14 11.2 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 ABC-2 type transporter UDPGT PF00201.13 CCF47601.1 - 6.7e-06 24.9 0.0 7.2e-06 24.8 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase UMP1 PF05348.6 CCF47602.1 - 5.8e-14 52.1 0.0 6.3e-14 52.0 0.0 1.0 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 ubiquitin PF00240.18 CCF47603.1 - 0.007 15.7 0.0 0.0082 15.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.1 CCF47603.1 - 0.011 15.5 0.0 0.012 15.5 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Glyco_hydro_43 PF04616.9 CCF47604.1 - 1.5e-52 178.4 0.8 1.8e-52 178.1 0.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GFA PF04828.9 CCF47605.1 - 2.2e-20 72.3 0.5 3e-20 71.9 0.3 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme adh_short PF00106.20 CCF47607.1 - 2.4e-28 99.1 3.5 3.1e-28 98.7 2.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF47607.1 - 4.2e-27 95.4 0.0 5.6e-27 95.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF47607.1 - 3.2e-15 56.2 1.7 4.5e-15 55.7 1.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CCF47607.1 - 0.044 13.2 0.1 0.077 12.4 0.1 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CCF47607.1 - 0.068 11.8 0.1 0.097 11.3 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family SPOUT_MTase PF02590.12 CCF47607.1 - 0.083 12.6 0.0 9.6 5.9 0.0 2.3 2 0 0 2 2 2 0 Predicted SPOUT methyltransferase PAS_3 PF08447.6 CCF47612.1 - 1.5e-08 34.5 0.0 1.8e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.1 CCF47612.1 - 1.7e-06 28.3 0.0 1.8e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 PAS domain PAS PF00989.19 CCF47612.1 - 3.8e-06 26.6 0.0 4.6e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.1 CCF47612.1 - 7.5e-06 25.8 0.0 7.9e-06 25.8 0.0 1.0 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.5 CCF47612.1 - 0.02 14.9 0.0 0.022 14.8 0.0 1.1 1 0 0 1 1 1 0 PAS fold Peptidase_M35 PF02102.10 CCF47614.1 - 0.033 12.8 0.1 0.033 12.8 0.0 1.0 1 0 0 1 1 1 0 Deuterolysin metalloprotease (M35) family Glyco_hydro_35 PF01301.14 CCF47615.1 - 1.5e-59 201.9 0.0 1.7e-59 201.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Amidohydro_1 PF01979.15 CCF47616.1 - 3.9e-10 39.9 0.0 1.1e-09 38.4 0.0 1.7 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 CCF47616.1 - 1.3e-05 25.4 0.6 3.3e-05 24.0 0.2 1.9 1 1 1 2 2 2 1 Amidohydrolase Amidohydro_3 PF07969.6 CCF47616.1 - 0.0036 16.5 0.0 0.0069 15.6 0.0 1.4 1 1 0 1 1 1 1 Amidohydrolase family Mid2 PF04478.7 CCF47617.1 - 2.5e-06 26.9 1.2 2.5e-06 26.9 0.9 2.5 2 1 1 3 3 3 1 Mid2 like cell wall stress sensor DUF533 PF04391.7 CCF47617.1 - 0.086 12.2 0.2 0.086 12.2 0.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF533) Mitofilin PF09731.4 CCF47617.1 - 0.22 10.1 7.2 0.3 9.7 5.0 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein FAM53 PF15242.1 CCF47617.1 - 3.2 7.1 17.5 3.1 7.2 11.5 1.4 1 1 0 1 1 1 0 Family of FAM53 GCR PF02155.10 CCF47618.1 - 0.022 13.5 0.0 0.023 13.4 0.0 1.0 1 0 0 1 1 1 0 Glucocorticoid receptor WTF PF03303.8 CCF47620.1 - 0.05 13.0 0.3 0.073 12.4 0.2 1.2 1 0 0 1 1 1 0 WTF protein DUF2151 PF10221.4 CCF47621.1 - 0.15 10.2 0.3 0.19 9.8 0.2 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator L51_S25_CI-B8 PF05047.11 CCF47622.1 - 3.9e-12 45.7 0.0 5.1e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain DUF605 PF04652.11 CCF47623.1 - 1.2 8.4 7.7 1.4 8.2 5.3 1.1 1 0 0 1 1 1 0 Vta1 like Glyco_hydro_47 PF01532.15 CCF47624.1 - 2.4e-136 454.9 0.0 2.8e-136 454.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 KR PF08659.5 CCF47625.1 - 5e-55 185.9 0.1 2.3e-54 183.7 0.1 2.3 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.16 CCF47625.1 - 9e-54 182.9 0.2 1.4e-53 182.3 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.1 CCF47625.1 - 2.5e-49 168.0 0.0 5e-49 167.0 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.20 CCF47625.1 - 1.4e-40 138.9 0.1 7.1e-40 136.6 0.1 2.3 1 0 0 1 1 1 1 short chain dehydrogenase Methyltransf_12 PF08242.7 CCF47625.1 - 3.7e-22 78.6 0.0 1.9e-21 76.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain ADH_zinc_N PF00107.21 CCF47625.1 - 1.6e-20 72.9 1.0 1.5e-19 69.8 0.0 3.1 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CCF47625.1 - 3.2e-14 53.8 0.0 5e-13 50.0 0.0 2.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_31 PF13847.1 CCF47625.1 - 3.2e-13 49.5 0.0 9.2e-13 48.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CCF47625.1 - 3.8e-12 46.2 0.0 8.2e-12 45.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CCF47625.1 - 1.6e-11 44.7 0.0 7.6e-11 42.5 0.0 2.2 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF47625.1 - 2.2e-11 44.0 0.0 6.8e-11 42.5 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.20 CCF47625.1 - 1.9e-07 31.2 0.0 1.7e-06 28.2 0.0 2.6 2 0 0 2 2 2 1 Phosphopantetheine attachment site Methyltransf_26 PF13659.1 CCF47625.1 - 5.1e-07 29.7 0.0 4.1e-06 26.8 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain ADH_N PF08240.7 CCF47625.1 - 1.7e-06 27.7 2.4 4.3e-06 26.4 0.0 2.7 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain Ubie_methyltran PF01209.13 CCF47625.1 - 8.6e-06 25.0 0.0 2e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF938 PF06080.7 CCF47625.1 - 0.0003 20.3 0.0 0.0009 18.8 0.0 1.7 2 0 0 2 2 1 1 Protein of unknown function (DUF938) DREV PF05219.7 CCF47625.1 - 0.017 14.0 0.0 0.033 13.0 0.0 1.4 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_16 PF10294.4 CCF47625.1 - 0.022 14.2 0.0 0.11 11.9 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_28 PF02636.12 CCF47625.1 - 0.025 13.9 0.0 0.057 12.7 0.0 1.5 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF915 PF06028.6 CCF47625.1 - 0.064 12.3 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) CheR PF01739.13 CCF47625.1 - 0.078 12.2 0.0 9.6 5.4 0.0 2.6 2 1 1 3 3 2 0 CheR methyltransferase, SAM binding domain RrnaAD PF00398.15 CCF47625.1 - 0.35 9.8 0.0 0.66 8.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DUF824 PF05688.6 CCF47628.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF824) PUCC PF03209.10 CCF47629.1 - 0.00013 20.8 7.6 0.0018 17.0 3.3 2.0 1 1 1 2 2 2 2 PUCC protein MFS_1 PF07690.11 CCF47629.1 - 0.0066 15.2 6.7 0.0066 15.2 4.7 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily EI24 PF07264.6 CCF47629.1 - 0.054 12.9 1.3 0.096 12.1 0.9 1.5 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) p450 PF00067.17 CCF47631.1 - 6.1e-22 77.7 0.0 7.3e-22 77.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Mg_trans_NIPA PF05653.9 CCF47634.1 - 4.9e-99 331.0 12.1 6.1e-99 330.7 8.4 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EmrE PF13536.1 CCF47634.1 - 2.2e-07 31.0 1.8 2.2e-07 31.0 1.3 3.2 2 1 1 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 CCF47634.1 - 0.00015 21.7 7.4 0.00015 21.7 5.2 3.3 3 1 1 4 4 4 1 EamA-like transporter family NfeD PF01957.13 CCF47634.1 - 9.1 6.4 13.1 1 9.5 0.1 3.2 1 1 2 3 3 3 0 NfeD-like C-terminal, partner-binding Ribosomal_S3_C PF00189.15 CCF47635.1 - 1.2e-16 60.6 0.1 2.6e-16 59.6 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.12 CCF47635.1 - 2.7e-12 46.0 0.1 4.6e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.3 CCF47635.1 - 0.057 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Myotub-related PF06602.9 CCF47636.1 - 1.1e-128 428.9 0.2 1.6e-128 428.4 0.2 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.1 CCF47636.1 - 0.017 15.3 0.0 0.059 13.6 0.0 1.8 1 1 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.22 CCF47636.1 - 0.032 13.5 0.0 0.075 12.3 0.0 1.5 1 1 0 1 1 1 0 Protein-tyrosine phosphatase HTH_Tnp_Tc5 PF03221.11 CCF47638.1 - 0.11 12.2 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain Patatin PF01734.17 CCF47639.1 - 7.7e-07 29.2 0.2 1.2e-06 28.5 0.2 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase Pectate_lyase_3 PF12708.2 CCF47641.1 - 3.5e-26 92.7 13.0 5.9e-20 72.3 1.6 2.8 3 0 0 3 3 3 2 Pectate lyase superfamily protein Beta_helix PF13229.1 CCF47641.1 - 0.0014 18.4 9.2 0.0014 18.4 6.4 2.1 1 1 1 2 2 2 2 Right handed beta helix region NosD PF05048.8 CCF47641.1 - 0.0068 15.5 8.1 0.011 14.9 5.6 1.4 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) ELYS PF13934.1 CCF47642.1 - 1.9e-64 217.5 0.5 2.1e-64 217.3 0.4 1.0 1 0 0 1 1 1 1 Nuclear pore complex assembly PAT1 PF09770.4 CCF47643.1 - 2.7 6.1 14.5 3.9 5.5 10.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 OPT PF03169.10 CCF47644.1 - 1.1e-79 268.5 27.3 1.3e-79 268.3 18.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Hemerythrin PF01814.18 CCF47645.1 - 1.2e-12 48.1 1.1 1.5e-12 47.8 0.8 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF4210 PF13915.1 CCF47646.1 - 2.3e-24 85.4 0.0 5.4e-24 84.2 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) Chromosome_seg PF13889.1 CCF47646.1 - 3.1e-21 74.9 0.6 6.5e-21 73.9 0.4 1.6 1 0 0 1 1 1 1 Chromosome segregation during meiosis RRM_6 PF14259.1 CCF47647.1 - 1.8e-12 47.0 0.1 8.9e-12 44.8 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF47647.1 - 7.1e-10 38.5 0.1 3.3e-09 36.4 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CCF47647.1 - 2e-08 33.8 0.1 0.008 15.9 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_1 PF00076.17 CCF47647.1 - 7.4e-08 31.9 0.3 1.2e-06 28.0 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.12 CCF47647.1 - 2.1e-06 27.7 0.0 5.6e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 PWI domain zf-CCCH PF00642.19 CCF47647.1 - 6.9e-06 25.6 2.8 1.3e-05 24.6 2.0 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Borrelia_P83 PF05262.6 CCF47647.1 - 0.0012 17.2 5.7 0.0016 16.7 4.0 1.2 1 0 0 1 1 1 1 Borrelia P83/100 protein RRM_3 PF08777.6 CCF47647.1 - 0.11 12.3 10.6 2.3 8.0 3.4 3.4 2 1 1 3 3 3 0 RNA binding motif Seryl_tRNA_N PF02403.17 CCF47647.1 - 0.14 12.2 11.7 0.34 10.9 8.1 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain EFG_IV PF03764.13 CCF47648.1 - 5.1e-37 126.0 0.0 1.1e-36 125.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 CCF47648.1 - 7.3e-23 80.2 0.0 2.3e-22 78.6 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 CCF47648.1 - 2.2e-13 50.1 0.8 1e-12 47.9 0.1 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.1 CCF47648.1 - 4.6e-12 45.6 0.0 1.4e-11 44.1 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II DUF1962 PF09227.5 CCF47650.1 - 0.079 13.0 0.5 0.14 12.2 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1962) FRG2 PF15315.1 CCF47650.1 - 5.2 6.9 7.6 8 6.3 5.3 1.3 1 1 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 Ribosomal_L23 PF00276.15 CCF47651.1 - 1.3e-13 50.6 0.0 2.4e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L23 MT-A70 PF05063.9 CCF47652.1 - 2.5e-32 111.8 0.0 3.4e-32 111.4 0.0 1.2 1 0 0 1 1 1 1 MT-A70 Methyltransf_26 PF13659.1 CCF47652.1 - 0.00047 20.1 0.0 0.0017 18.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Mito_carr PF00153.22 CCF47653.1 - 8.3e-59 195.3 3.3 8.3e-21 73.5 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Methyltransf_3 PF01596.12 CCF47654.1 - 3.6e-14 52.2 0.0 5e-14 51.8 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.1 CCF47654.1 - 4.8e-09 36.9 0.0 8.3e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.7 CCF47654.1 - 0.031 13.6 0.0 0.055 12.7 0.0 1.4 1 0 0 1 1 1 0 Cephalosporin hydroxylase Methyltransf_26 PF13659.1 CCF47654.1 - 0.048 13.7 1.3 0.15 12.0 0.6 1.9 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.2 CCF47654.1 - 0.11 13.1 0.0 0.22 12.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain DHQ_synthase PF01761.15 CCF47655.1 - 7.3e-30 103.7 0.1 1.1e-29 103.2 0.1 1.2 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.1 CCF47655.1 - 7.4e-09 35.2 0.0 8.6e-09 35.0 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.14 CCF47655.1 - 0.11 11.1 0.0 0.12 10.9 0.0 1.1 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase Cofilin_ADF PF00241.15 CCF47656.1 - 1.2e-26 93.0 0.0 1.3e-12 47.6 0.0 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein AlaDh_PNT_N PF05222.10 CCF47657.1 - 1.9e-28 99.1 0.0 2.7e-28 98.6 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.16 CCF47657.1 - 0.00031 20.3 0.0 0.00057 19.4 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 3A PF00803.13 CCF47658.1 - 0.16 10.9 0.1 0.23 10.5 0.1 1.2 1 0 0 1 1 1 0 3A/RNA2 movement protein family PhoQ_Sensor PF08918.5 CCF47660.1 - 0.046 13.2 0.0 0.091 12.2 0.0 1.4 1 0 0 1 1 1 0 PhoQ Sensor DUF2569 PF10754.4 CCF47660.1 - 0.29 11.3 3.9 0.12 12.5 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) adh_short PF00106.20 CCF47662.1 - 1.4e-14 54.3 3.5 2.5e-14 53.5 2.4 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CCF47662.1 - 0.00014 21.6 2.0 0.00014 21.6 1.4 1.6 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.1 CCF47662.1 - 0.0015 18.3 0.0 0.0021 17.8 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 CCF47662.1 - 0.05 13.0 0.1 0.15 11.4 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 CCF47662.1 - 0.21 11.4 4.2 1.1 9.0 0.3 3.0 3 1 0 3 3 3 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF2306 PF10067.4 CCF47663.1 - 4.3e-13 49.2 7.4 4.3e-13 49.2 5.1 2.1 3 0 0 3 3 3 1 Predicted membrane protein (DUF2306) DUF997 PF06196.7 CCF47663.1 - 0.083 12.4 0.5 0.44 10.0 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF997) HMGL-like PF00682.14 CCF47664.1 - 9.7e-61 205.4 0.3 1.4e-60 204.9 0.2 1.1 1 0 0 1 1 1 1 HMGL-like Epimerase PF01370.16 CCF47665.1 - 8.4e-12 45.0 0.0 1.2e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CCF47665.1 - 4.5e-07 30.0 0.1 3.7e-06 27.0 0.1 2.0 1 1 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 CCF47665.1 - 1.6e-06 27.0 0.0 2.6e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 CCF47665.1 - 2.6e-05 23.2 0.0 0.0011 17.9 0.0 2.3 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 CCF47665.1 - 9.3e-05 22.4 0.0 0.00034 20.5 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.8 CCF47665.1 - 0.0047 16.2 0.1 0.0073 15.5 0.1 1.4 1 1 0 1 1 1 1 NmrA-like family Pro-kuma_activ PF09286.6 CCF47669.1 - 2.2e-28 99.0 0.0 7.5e-28 97.3 0.0 1.9 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 CCF47669.1 - 1.3e-06 27.7 0.3 2.3e-06 26.9 0.2 1.4 1 0 0 1 1 1 1 Subtilase family FAD_binding_4 PF01565.18 CCF47670.1 - 8.8e-22 77.0 0.1 1.3e-21 76.5 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 CCF47671.1 - 2.9e-12 46.8 0.1 4.1e-05 23.5 0.0 2.7 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CCF47671.1 - 1.3e-10 41.5 0.1 6.6e-08 32.8 0.1 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CCF47671.1 - 2.5e-06 27.7 0.1 0.015 15.3 0.0 3.1 1 1 2 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CCF47671.1 - 0.0032 16.1 1.3 1.6 7.2 0.8 2.7 2 1 1 3 3 3 2 Tryptophan halogenase Abhydrolase_5 PF12695.2 CCF47671.1 - 0.034 13.8 0.8 0.88 9.3 0.1 2.6 1 1 2 3 3 3 0 Alpha/beta hydrolase family HI0933_like PF03486.9 CCF47671.1 - 0.12 10.8 0.2 4.6 5.6 0.0 2.3 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_9 PF13454.1 CCF47671.1 - 0.18 11.5 4.6 16 5.2 0.1 3.7 4 0 0 4 4 4 0 FAD-NAD(P)-binding DAO PF01266.19 CCF47671.1 - 2.3 7.0 7.8 7.3 5.3 0.0 3.5 2 1 1 4 4 4 0 FAD dependent oxidoreductase Pec_lyase_C PF00544.14 CCF47673.1 - 3e-24 85.6 4.9 4.2e-24 85.1 3.4 1.2 1 0 0 1 1 1 1 Pectate lyase AAA_29 PF13555.1 CCF47673.1 - 0.11 12.0 0.8 3.8 7.1 0.1 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain CLTH PF10607.4 CCF47674.1 - 3.2e-14 52.8 0.0 3.3e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain Miro PF08477.8 CCF47677.1 - 2.3e-07 31.3 0.0 2.9e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Miro-like protein Ras PF00071.17 CCF47677.1 - 2.1e-06 27.2 0.0 3.6e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Ras family PduV-EutP PF10662.4 CCF47677.1 - 0.045 13.2 0.0 0.13 11.7 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.5 CCF47677.1 - 0.057 12.6 0.0 0.084 12.0 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Glyco_transf_28 PF03033.15 CCF47679.1 - 1.3e-07 31.4 0.2 1.4e-07 31.4 0.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_trans_4_4 PF13579.1 CCF47679.1 - 0.0032 17.6 2.0 0.0035 17.5 1.4 1.1 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Flocculin_t3 PF13928.1 CCF47680.1 - 0.032 14.3 7.4 0.032 14.3 5.1 3.3 2 2 1 3 3 3 0 Flocculin type 3 repeat AMP-binding PF00501.23 CCF47681.1 - 1.5e-75 254.2 0.0 1.8e-75 253.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CCF47681.1 - 1.4e-16 61.1 0.1 4.6e-16 59.5 0.1 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PTCB-BRCT PF12738.2 CCF47682.1 - 0.00013 21.7 0.5 0.00031 20.5 0.1 1.8 2 0 0 2 2 2 1 twin BRCT domain BRCT PF00533.21 CCF47682.1 - 0.00015 21.8 0.0 0.0003 20.8 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Peptidase_S8 PF00082.17 CCF47683.1 - 0.00027 20.1 0.0 0.00032 19.9 0.0 1.1 1 0 0 1 1 1 1 Subtilase family HsbA PF12296.3 CCF47684.1 - 2.8e-20 72.4 10.5 2.8e-20 72.4 7.3 1.6 2 0 0 2 2 2 1 Hydrophobic surface binding protein A HHH_8 PF14716.1 CCF47684.1 - 0.043 14.0 0.7 2.6 8.3 0.1 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix domain NPV_P10 PF05531.7 CCF47684.1 - 2.4 8.4 5.7 38 4.6 4.0 2.6 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein peroxidase PF00141.18 CCF47686.1 - 1.1e-26 93.7 0.0 1.4e-26 93.3 0.0 1.2 1 0 0 1 1 1 1 Peroxidase ATP-synt PF00231.14 CCF47687.1 - 5.5e-29 101.4 0.8 6.8e-29 101.1 0.6 1.0 1 0 0 1 1 1 1 ATP synthase Amino_oxidase PF01593.19 CCF47688.1 - 1.2e-81 275.1 0.2 2.6e-81 274.0 0.1 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase HMG_box PF00505.14 CCF47688.1 - 1.1e-07 31.9 1.3 1.1e-07 31.9 0.9 1.9 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 CCF47688.1 - 1.2e-07 32.0 1.8 2.2e-07 31.1 1.3 1.5 1 0 0 1 1 1 1 HMG-box domain NAD_binding_8 PF13450.1 CCF47688.1 - 1.6e-07 31.2 0.0 3.9e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SWIRM PF04433.12 CCF47688.1 - 2.7e-06 27.4 0.1 2.3e-05 24.4 0.1 2.2 2 0 0 2 2 2 1 SWIRM domain DAO PF01266.19 CCF47688.1 - 0.0097 14.8 0.0 0.071 12.0 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Sec1 PF00995.18 CCF47689.1 - 2e-139 465.8 0.0 2.3e-139 465.6 0.0 1.0 1 0 0 1 1 1 1 Sec1 family UQ_con PF00179.21 CCF47690.1 - 8.5e-29 99.7 0.0 9.9e-29 99.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CCF47690.1 - 2.2e-07 30.6 0.0 2.6e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 CCF47690.1 - 2.6e-05 24.0 0.0 3.1e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 CCF47690.1 - 0.0019 17.8 0.1 0.0025 17.4 0.0 1.2 1 0 0 1 1 1 1 UEV domain Mito_carr PF00153.22 CCF47691.1 - 5.7e-35 118.9 0.6 5.1e-23 80.6 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein MtrF PF09472.5 CCF47691.1 - 0.22 10.7 1.6 0.39 9.9 0.2 2.0 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Xpo1 PF08389.7 CCF47692.1 - 2.3e-19 69.7 3.6 1.9e-18 66.8 0.1 2.8 2 1 1 3 3 3 1 Exportin 1-like protein HEAT PF02985.17 CCF47692.1 - 0.00015 21.5 0.0 0.35 11.0 0.0 2.8 2 0 0 2 2 2 2 HEAT repeat Phage_C PF12025.3 CCF47692.1 - 0.0014 18.5 0.0 0.0045 16.9 0.0 1.8 1 0 0 1 1 1 1 Phage protein C TipAS PF07739.8 CCF47692.1 - 0.066 13.5 2.5 7.5 6.9 0.0 2.9 3 0 0 3 3 3 0 TipAS antibiotic-recognition domain GlutR_dimer PF00745.15 CCF47692.1 - 0.12 12.3 2.0 0.52 10.2 0.1 2.5 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain COesterase PF00135.23 CCF47693.1 - 5.6e-05 22.0 0.0 6.3e-05 21.8 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_1 PF00561.15 CCF47696.1 - 2.5e-09 37.0 0.0 3.9e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CCF47696.1 - 2.4e-08 34.1 0.0 2.7e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CCF47696.1 - 0.00036 20.3 0.0 0.00052 19.8 0.0 1.3 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_5 PF12695.2 CCF47696.1 - 0.0018 18.0 0.1 0.0022 17.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.7 CCF47696.1 - 0.013 13.9 0.5 2.4 6.5 0.0 2.0 1 1 1 2 2 2 0 Acetyl xylan esterase (AXE1) zf-DHHC PF01529.15 CCF47697.1 - 5e-42 143.2 5.3 7.8e-42 142.6 3.6 1.3 1 0 0 1 1 1 1 DHHC palmitoyltransferase DZR PF12773.2 CCF47697.1 - 0.09 12.6 6.3 0.18 11.6 4.3 1.4 1 0 0 1 1 1 0 Double zinc ribbon LRR_6 PF13516.1 CCF47698.1 - 0.0004 20.1 0.0 0.13 12.3 0.0 4.7 5 0 0 5 5 5 1 Leucine Rich repeat Med15 PF09606.5 CCF47698.1 - 1.2 7.2 23.6 1.3 7.0 16.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal BAF1_ABF1 PF04684.8 CCF47698.1 - 6.3 5.5 24.9 12 4.6 17.2 1.4 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SNF2_N PF00176.18 CCF47699.1 - 1.4e-60 204.6 0.0 2.3e-60 203.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4 PF00097.20 CCF47699.1 - 8.2e-06 25.3 10.7 8.2e-06 25.3 7.4 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.24 CCF47699.1 - 0.00035 20.1 0.0 0.00072 19.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_34 PF13872.1 CCF47699.1 - 0.00037 19.3 0.0 0.0047 15.7 0.0 2.5 2 1 0 2 2 2 1 P-loop containing NTP hydrolase pore-1 zf-C3HC4_2 PF13923.1 CCF47699.1 - 0.0017 18.3 10.2 0.0017 18.3 7.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CCF47699.1 - 0.0019 18.0 11.5 0.0019 18.0 8.0 2.2 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 CCF47699.1 - 7 6.8 16.1 0.18 11.9 6.2 2.0 2 0 0 2 2 2 0 RING-H2 zinc finger PKD PF00801.15 CCF47700.1 - 0.021 14.5 0.0 0.029 14.0 0.0 1.2 1 0 0 1 1 1 0 PKD domain PP-binding PF00550.20 CCF47701.1 - 8.6e-11 41.9 0.5 1.6e-10 41.0 0.3 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site UxaC PF02614.9 CCF47701.1 - 0.21 10.1 0.0 0.31 9.5 0.0 1.2 1 0 0 1 1 1 0 Glucuronate isomerase Zip PF02535.17 CCF47702.1 - 0.33 9.9 4.9 0.29 10.1 3.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Mg_trans_NIPA PF05653.9 CCF47703.1 - 3.7e-37 127.9 5.8 4.8e-37 127.5 4.0 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA DUF4401 PF14351.1 CCF47703.1 - 0.0024 16.9 9.2 0.004 16.1 6.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4401) DUF998 PF06197.8 CCF47703.1 - 0.0045 16.3 0.0 0.0045 16.3 0.0 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF998) TctB PF07331.6 CCF47703.1 - 0.033 13.8 11.2 1.3 8.6 6.6 2.3 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family DUF3366 PF11846.3 CCF47703.1 - 0.17 11.7 0.6 0.38 10.6 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3366) DUF1772 PF08592.6 CCF47703.1 - 7 6.3 8.1 0.69 9.6 1.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) RRM_1 PF00076.17 CCF47704.1 - 2.7e-58 193.4 0.0 8.9e-17 60.4 0.0 6.1 5 1 1 6 6 6 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CCF47704.1 - 1.7e-47 159.2 0.0 2.3e-14 53.1 0.0 5.7 5 1 1 6 6 6 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF47704.1 - 4.4e-19 68.0 0.7 0.00012 21.8 0.0 5.4 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CENP-B_dimeris PF09026.5 CCF47704.1 - 0.0077 16.4 11.5 0.0077 16.4 8.0 2.5 2 0 0 2 2 2 1 Centromere protein B dimerisation domain Cnd3 PF12719.2 CCF47705.1 - 5.4e-94 314.5 4.7 5.4e-94 314.5 3.3 1.9 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.1 CCF47705.1 - 3.6e-08 33.5 15.7 9.9e-05 22.5 1.2 5.1 4 2 1 5 5 5 3 HEAT repeats HEAT PF02985.17 CCF47705.1 - 6.8e-07 28.8 7.3 0.11 12.6 0.0 7.3 8 0 0 8 8 8 1 HEAT repeat DUF1546 PF07571.8 CCF47705.1 - 0.0024 17.9 0.6 0.7 10.0 0.0 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF1546) HEAT_EZ PF13513.1 CCF47705.1 - 0.47 11.0 20.9 0.056 13.9 1.3 6.2 4 1 2 6 6 6 0 HEAT-like repeat zf-Mss51 PF13824.1 CCF47707.1 - 3.2e-27 94.1 5.9 5.7e-27 93.3 4.1 1.4 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.13 CCF47707.1 - 0.0054 16.5 0.7 0.0099 15.7 0.5 1.4 1 0 0 1 1 1 1 MYND finger GFA PF04828.9 CCF47707.1 - 0.065 13.1 0.1 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme Cyt-b5 PF00173.23 CCF47708.1 - 8.7e-22 76.7 0.0 7.7e-17 60.8 0.0 2.7 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain C1_2 PF03107.11 CCF47709.1 - 0.0088 16.1 0.6 0.016 15.2 0.4 1.5 1 0 0 1 1 1 1 C1 domain Methyltransf_12 PF08242.7 CCF47710.1 - 8.8e-05 22.9 0.0 0.0001 22.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CCF47710.1 - 0.016 15.6 0.0 0.019 15.4 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 CCF47710.1 - 0.037 13.6 0.0 0.038 13.5 0.0 1.0 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 CCF47710.1 - 0.052 13.2 0.0 0.059 13.0 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain ChlI PF13541.1 CCF47710.1 - 0.12 11.9 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 Subunit ChlI of Mg-chelatase Flavokinase PF01687.12 CCF47712.1 - 2.2e-21 76.0 0.0 2.6e-21 75.8 0.0 1.0 1 0 0 1 1 1 1 Riboflavin kinase PAS PF00989.19 CCF47713.1 - 0.00019 21.2 0.0 0.00044 20.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.13 CCF47713.1 - 0.0023 17.7 8.8 0.0053 16.6 6.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.11 CCF47714.1 - 9.4e-35 119.9 30.4 1.2e-34 119.6 21.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF47714.1 - 6.8e-15 54.5 10.4 1.9e-14 53.1 7.3 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 CCF47714.1 - 8.6e-10 37.4 3.9 1.2e-09 36.9 2.7 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.8 CCF47714.1 - 0.0037 15.4 3.8 0.0055 14.8 2.6 1.2 1 0 0 1 1 1 1 Transmembrane secretion effector DUF3602 PF12223.3 CCF47715.1 - 2.2e-15 56.7 3.6 4.9e-11 42.8 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3602) Lipase_GDSL PF00657.17 CCF47719.1 - 3.2e-12 46.8 0.6 5e-12 46.1 0.4 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase BPL_N PF09825.4 CCF47720.1 - 4.3e-127 423.8 0.0 5.3e-127 423.6 0.0 1.0 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal ADH_N PF08240.7 CCF47721.1 - 8.2e-29 99.5 0.3 1.8e-28 98.4 0.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CCF47721.1 - 2.4e-10 40.0 0.5 4.9e-10 39.0 0.4 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.1 CCF47721.1 - 4.5e-06 26.1 0.5 1e-05 25.0 0.3 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated HI0933_like PF03486.9 CCF47721.1 - 0.0021 16.6 0.1 0.0028 16.1 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein Shikimate_DH PF01488.15 CCF47721.1 - 0.019 15.0 0.1 0.042 13.9 0.0 1.5 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.16 CCF47721.1 - 0.024 14.1 0.3 0.041 13.4 0.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.14 CCF47721.1 - 0.027 13.5 0.1 0.04 12.9 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.22 CCF47721.1 - 0.029 14.7 0.5 0.58 10.6 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CCF47721.1 - 0.033 13.1 0.3 0.05 12.5 0.2 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 CCF47721.1 - 0.048 13.7 0.2 0.076 13.0 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CCF47721.1 - 0.074 11.8 0.8 0.11 11.3 0.5 1.2 1 0 0 1 1 1 0 FAD binding domain Methyltransf_31 PF13847.1 CCF47721.1 - 0.076 12.6 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain 3HCDH_N PF02737.13 CCF47721.1 - 0.087 12.4 0.3 0.11 12.0 0.2 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.17 CCF47721.1 - 0.15 10.9 0.4 0.2 10.4 0.3 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A FYVE_2 PF02318.11 CCF47723.1 - 0.00088 19.1 21.1 0.31 10.9 1.9 3.3 3 0 0 3 3 3 3 FYVE-type zinc finger DUF2360 PF10152.4 CCF47723.1 - 4.1 7.6 7.8 0.86 9.8 3.0 1.6 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) Abhydrolase_3 PF07859.8 CCF47725.1 - 3.2e-07 30.1 0.0 5.2e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 CCF47725.1 - 0.041 12.5 0.0 0.049 12.3 0.0 1.1 1 0 0 1 1 1 0 Carboxylesterase family FixQ PF05545.6 CCF47726.1 - 0.016 14.8 0.3 0.029 14.0 0.2 1.4 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ MFS_1 PF07690.11 CCF47727.1 - 2.1e-15 56.2 13.0 2.1e-15 56.2 9.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2681 PF10883.3 CCF47727.1 - 0.015 15.5 2.5 0.018 15.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Hist_deacetyl PF00850.14 CCF47729.1 - 4.2e-77 259.4 0.0 8.5e-77 258.4 0.0 1.5 1 1 1 2 2 2 1 Histone deacetylase domain ING PF12998.2 CCF47730.1 - 1.1e-23 83.4 3.3 1.6e-23 82.9 2.3 1.2 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.24 CCF47730.1 - 1e-07 31.5 9.1 1e-07 31.5 6.3 1.7 2 0 0 2 2 2 1 PHD-finger BUD22 PF09073.5 CCF47730.1 - 0.013 14.5 0.6 0.021 13.8 0.4 1.2 1 0 0 1 1 1 0 BUD22 zf-HC5HC2H PF13771.1 CCF47730.1 - 0.035 14.2 0.1 0.092 12.8 0.0 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain OMP_b-brl_3 PF14905.1 CCF47730.1 - 0.21 10.2 0.1 0.32 9.6 0.1 1.2 1 0 0 1 1 1 0 Outer membrane protein beta-barrel family Septin PF00735.13 CCF47732.1 - 1.4e-43 148.9 0.7 1.6e-43 148.7 0.5 1.0 1 0 0 1 1 1 1 Septin IBR PF01485.16 CCF47735.1 - 3.8e-07 29.8 10.8 9.1e-07 28.6 7.5 1.6 1 0 0 1 1 1 1 IBR domain Mnd1 PF03962.10 CCF47735.1 - 0.59 9.7 11.6 0.89 9.1 8.1 1.2 1 0 0 1 1 1 0 Mnd1 family FG-GAP_2 PF14312.1 CCF47737.1 - 0.03 14.3 0.8 0.039 13.9 0.1 1.6 2 0 0 2 2 2 0 FG-GAP repeat FAD_binding_2 PF00890.19 CCF47738.1 - 1.5e-123 412.7 4.8 1.9e-123 412.4 3.3 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.15 CCF47738.1 - 8.3e-46 155.0 0.2 1.2e-45 154.4 0.1 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.9 CCF47738.1 - 4.1e-07 30.0 0.1 0.0023 17.8 0.1 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CCF47738.1 - 8.7e-06 24.9 0.1 0.0078 15.3 0.0 2.6 3 0 0 3 3 3 2 Thi4 family GIDA PF01134.17 CCF47738.1 - 3.4e-05 22.8 1.4 0.014 14.3 1.5 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A DAO PF01266.19 CCF47738.1 - 0.00029 19.8 0.1 0.0039 16.1 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 CCF47738.1 - 0.0075 15.3 0.1 0.0075 15.3 0.1 2.4 3 0 0 3 3 3 1 FAD binding domain HI0933_like PF03486.9 CCF47738.1 - 0.082 11.3 1.1 0.24 9.8 0.4 2.0 2 0 0 2 2 2 0 HI0933-like protein Fer2_3 PF13085.1 CCF47739.1 - 1.8e-32 111.4 0.0 2.8e-32 110.7 0.0 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_8 PF13183.1 CCF47739.1 - 2.2e-09 37.1 4.2 2.2e-09 37.1 2.9 1.9 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_17 PF13534.1 CCF47739.1 - 2.3e-09 37.4 6.0 2.3e-09 37.4 4.2 2.1 2 0 0 2 2 1 1 4Fe-4S dicluster domain Fer4_18 PF13746.1 CCF47739.1 - 4e-05 23.9 7.2 5e-05 23.6 0.8 2.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.1 CCF47739.1 - 7.7e-05 22.8 3.9 0.043 14.0 0.4 3.1 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_10 PF13237.1 CCF47739.1 - 0.00014 21.5 4.2 0.00014 21.5 2.9 2.2 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.22 CCF47739.1 - 0.0012 18.5 2.6 0.0022 17.6 0.2 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.2 CCF47739.1 - 0.0043 17.4 5.3 0.0043 17.4 3.7 2.4 2 1 0 2 2 2 1 4Fe-4S dicluster domain DNA_pol3_tau_4 PF12168.3 CCF47739.1 - 0.59 10.5 2.7 3.5 8.1 0.2 2.4 2 0 0 2 2 2 0 DNA polymerase III subunits tau domain IV DnaB-binding Fer4_2 PF12797.2 CCF47739.1 - 1.9 8.6 16.7 1.9 8.5 3.1 3.3 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_15 PF13459.1 CCF47739.1 - 4.1 8.0 7.1 1.1 9.8 0.1 2.6 3 0 0 3 3 2 0 4Fe-4S single cluster domain DUF3712 PF12505.3 CCF47740.1 - 6.8e-24 84.2 4.2 1.4e-23 83.3 2.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) DUF4137 PF13593.1 CCF47740.1 - 0.01 14.9 0.1 0.015 14.4 0.1 1.1 1 0 0 1 1 1 0 SBF-like CPA transporter family (DUF4137) DUF805 PF05656.9 CCF47740.1 - 0.044 13.6 0.5 0.073 12.8 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF805) FAD_binding_2 PF00890.19 CCF47741.1 - 0.16 10.7 0.0 0.25 10.1 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Ketoacyl-synt_C PF02801.17 CCF47742.1 - 3.6e-32 110.6 0.1 6.3e-32 109.9 0.1 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.16 CCF47742.1 - 1.4e-12 47.5 0.0 2.3e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Pex14_N PF04695.8 CCF47744.1 - 6.6e-23 81.2 1.3 6.6e-23 81.2 0.9 2.4 2 1 1 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region PAT1 PF09770.4 CCF47744.1 - 0.52 8.4 13.2 0.7 8.0 9.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PAPA-1 PF04795.7 CCF47745.1 - 5.7e-21 75.0 0.1 5.7e-21 75.0 0.1 3.8 5 1 0 5 5 5 1 PAPA-1-like conserved region Baculo_E56 PF04639.7 CCF47745.1 - 0.055 12.1 0.1 0.083 11.5 0.1 1.1 1 0 0 1 1 1 0 Baculoviral E56 protein, specific to ODV envelope Cu-oxidase PF00394.17 CCF47746.1 - 1.4e-14 54.3 0.0 1.9e-14 53.8 0.0 1.2 1 1 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 CCF47749.1 - 3e-06 26.7 0.0 4.7e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Multicopper oxidase AMMECR1 PF01871.12 CCF47750.1 - 2e-45 153.9 0.0 7.4e-45 152.1 0.0 1.7 2 0 0 2 2 2 1 AMMECR1 HMGL-like PF00682.14 CCF47752.1 - 2e-50 171.6 0.0 2.8e-50 171.1 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.5 CCF47752.1 - 2.2e-22 79.2 0.0 5.2e-22 78.0 0.0 1.7 1 1 0 1 1 1 1 LeuA allosteric (dimerisation) domain LysM PF01476.15 CCF47753.1 - 1.8e-10 40.5 0.6 0.0021 17.9 0.0 3.7 4 0 0 4 4 4 3 LysM domain Lamp PF01299.12 CCF47753.1 - 1.6 7.8 11.3 2 7.5 0.0 3.0 3 0 0 3 3 3 0 Lysosome-associated membrane glycoprotein (Lamp) zf-C3HC4_3 PF13920.1 CCF47754.1 - 4.3e-06 26.2 9.0 4.3e-06 26.2 6.2 3.4 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CCF47754.1 - 0.012 15.2 13.1 0.012 15.2 9.1 3.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) E_raikovi_mat PF06360.6 CCF47754.1 - 4.9 7.4 8.1 1.2 9.4 0.4 3.1 3 0 0 3 3 3 0 Euplotes raikovi mating pheromone Rhamno_transf PF11316.3 CCF47755.1 - 0.088 11.9 0.1 0.1 11.7 0.1 1.0 1 0 0 1 1 1 0 Putative rhamnosyl transferase Taxilin PF09728.4 CCF47756.1 - 5e-51 173.6 33.8 5.6e-51 173.4 23.5 1.0 1 0 0 1 1 1 1 Myosin-like coiled-coil protein TMF_TATA_bd PF12325.3 CCF47756.1 - 0.013 15.2 10.1 0.013 15.2 7.0 3.1 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Cep57_MT_bd PF06657.8 CCF47756.1 - 0.2 11.5 6.9 0.062 13.2 2.3 2.1 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 GAS PF13851.1 CCF47756.1 - 0.64 9.1 30.2 0.28 10.3 13.5 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding TSC22 PF01166.13 CCF47756.1 - 3.6 7.6 16.4 0.47 10.4 1.6 3.4 3 1 0 3 3 3 0 TSC-22/dip/bun family Seryl_tRNA_N PF02403.17 CCF47756.1 - 7.8 6.5 25.8 3.7 7.5 1.6 2.8 1 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Aminotran_3 PF00202.16 CCF47758.1 - 6.2e-82 275.1 0.0 7e-82 274.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III OPT PF03169.10 CCF47759.1 - 0.62 8.4 4.1 0.69 8.2 2.8 1.0 1 0 0 1 1 1 0 OPT oligopeptide transporter protein SRP-alpha_N PF04086.8 CCF47760.1 - 7.4 5.8 10.5 9.3 5.5 7.3 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Ribosomal_S19 PF00203.16 CCF47763.1 - 1.5e-33 114.2 0.3 2.2e-33 113.7 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S19 DUF462 PF04315.7 CCF47763.1 - 0.087 12.1 0.0 7 6.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF462 Glyco_hydro_53 PF07745.8 CCF47764.1 - 4.3e-105 351.1 0.4 4.8e-105 351.0 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 NTF2 PF02136.15 CCF47766.1 - 2.4e-30 105.3 0.1 2.7e-30 105.1 0.1 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4518 PF15008.1 CCF47766.1 - 0.0093 15.0 0.1 0.049 12.6 0.1 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4518) Pro_CA PF00484.14 CCF47767.1 - 6.2e-46 156.1 0.5 8.7e-46 155.7 0.3 1.2 1 0 0 1 1 1 1 Carbonic anhydrase Ribosomal_L7Ae PF01248.21 CCF47768.1 - 1e-20 73.0 0.5 1.7e-20 72.3 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family ATP_bind_3 PF01171.15 CCF47769.1 - 3.7e-18 65.6 0.0 6.1e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 PP-loop family DUF2392 PF10288.4 CCF47769.1 - 0.0013 19.0 0.0 0.0042 17.3 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2392) RecR PF02132.10 CCF47769.1 - 0.0038 16.6 0.2 0.0038 16.6 0.2 2.8 3 0 0 3 3 3 1 RecR protein tRNA_Me_trans PF03054.11 CCF47769.1 - 0.011 14.3 0.0 0.02 13.4 0.0 1.4 1 0 0 1 1 1 0 tRNA methyl transferase zf-UBR PF02207.15 CCF47769.1 - 0.24 11.1 8.8 0.58 9.9 0.1 2.9 3 0 0 3 3 3 0 Putative zinc finger in N-recognin (UBR box) MOZ_SAS PF01853.13 CCF47771.1 - 3.9e-79 264.2 0.0 5.6e-79 263.7 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family PHD PF00628.24 CCF47771.1 - 0.0059 16.2 9.2 0.0059 16.2 6.4 2.2 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.1 CCF47771.1 - 0.093 12.0 1.6 0.23 10.7 1.1 1.7 1 0 0 1 1 1 0 PHD-finger C1_1 PF00130.17 CCF47771.1 - 5 6.9 7.9 0.17 11.5 1.0 1.9 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DDE_1 PF03184.14 CCF47772.1 - 2.2e-28 98.8 0.0 3.7e-28 98.1 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 CCF47772.1 - 5.2e-12 45.3 0.3 1.3e-11 44.0 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.11 CCF47772.1 - 8.3e-12 44.4 0.2 1.5e-11 43.6 0.2 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_28 PF13518.1 CCF47772.1 - 0.00049 20.0 0.9 0.0013 18.6 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 CCF47772.1 - 0.0014 18.1 0.1 0.0047 16.5 0.1 1.9 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.10 CCF47772.1 - 0.0066 16.2 0.6 0.013 15.3 0.4 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_29 PF13551.1 CCF47772.1 - 0.015 15.4 0.5 0.042 14.0 0.4 1.9 1 1 0 1 1 1 0 Winged helix-turn helix HTH_Tnp_IS630 PF01710.11 CCF47772.1 - 0.015 14.9 0.0 0.028 14.0 0.0 1.5 1 0 0 1 1 1 0 Transposase HTH_8 PF02954.14 CCF47772.1 - 0.017 14.6 0.1 0.048 13.2 0.1 1.8 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_Tnp_1 PF01527.15 CCF47772.1 - 0.082 12.8 0.2 0.32 10.9 0.0 2.1 3 0 0 3 3 3 0 Transposase Sugar_tr PF00083.19 CCF47774.1 - 1.4e-15 56.8 20.7 1.5e-15 56.7 14.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Methyltransf_23 PF13489.1 CCF47775.1 - 0.1 12.3 0.0 0.11 12.1 0.0 1.0 1 0 0 1 1 1 0 Methyltransferase domain RabGAP-TBC PF00566.13 CCF47776.1 - 9.1e-08 31.8 0.0 1e-07 31.6 0.0 1.0 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GTP1_OBG PF01018.17 CCF47778.1 - 3.7e-37 127.3 1.1 7.6e-27 93.8 1.9 2.4 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.18 CCF47778.1 - 1.8e-22 79.4 0.0 3e-22 78.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CCF47778.1 - 6.6e-09 35.2 0.1 6.1e-08 32.0 0.0 2.4 3 0 0 3 3 3 1 Ferrous iron transport protein B ArgK PF03308.11 CCF47778.1 - 0.00014 20.7 0.1 0.11 11.2 0.0 2.2 2 0 0 2 2 2 2 ArgK protein GTP_EFTU PF00009.22 CCF47778.1 - 0.00031 20.2 0.0 0.069 12.5 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Arf PF00025.16 CCF47778.1 - 0.0011 18.3 0.0 0.082 12.1 0.0 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family ABC_tran PF00005.22 CCF47778.1 - 0.026 14.8 0.0 0.048 13.9 0.0 1.4 1 0 0 1 1 1 0 ABC transporter cobW PF02492.14 CCF47778.1 - 0.031 13.7 0.0 7.2 6.0 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.18 CCF47778.1 - 0.069 12.9 0.1 2 8.1 0.0 2.7 2 1 1 3 3 3 0 Dynamin family Aldolase_II PF00596.16 CCF47779.1 - 4e-44 150.4 0.0 5.1e-44 150.0 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Nol1_Nop2_Fmu PF01189.12 CCF47780.1 - 1.4e-44 152.6 0.0 3e-22 79.3 0.0 4.6 3 1 1 4 4 4 4 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 CCF47780.1 - 0.036 14.1 0.0 0.072 13.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Anoctamin PF04547.7 CCF47781.1 - 1.3e-43 149.3 0.0 1.6e-43 149.0 0.0 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel Glyco_hydro_18 PF00704.23 CCF47782.1 - 3.3e-78 263.5 0.8 3.7e-78 263.3 0.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CobN-Mg_chel PF02514.11 CCF47784.1 - 0.0045 14.4 0.0 0.0059 14.0 0.0 1.1 1 0 0 1 1 1 1 CobN/Magnesium Chelatase Tim17 PF02466.14 CCF47788.1 - 4.4e-31 107.5 9.1 5e-31 107.4 6.3 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF2628 PF10947.3 CCF47788.1 - 0.05 13.3 0.0 0.062 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) Nup84_Nup100 PF04121.8 CCF47789.1 - 2.2e-46 157.9 0.0 2.6e-27 94.8 0.0 2.5 2 1 0 2 2 2 2 Nuclear pore protein 84 / 107 Mod_r PF07200.8 CCF47790.1 - 6.1e-09 35.9 2.2 1.1e-08 35.1 1.5 1.5 1 1 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Glyco_hydro_3_C PF01915.17 CCF47792.1 - 1.3e-31 109.9 0.0 1.7e-31 109.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain PA14 PF07691.7 CCF47792.1 - 8.3e-09 35.2 0.0 1.3e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 PA14 domain Glyco_hydro_3 PF00933.16 CCF47792.1 - 6.1e-08 31.9 0.0 2.1e-07 30.2 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 N terminal domain SKG6 PF08693.5 CCF47794.1 - 0.0087 15.3 0.1 0.011 15.0 0.1 1.2 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF2627 PF11118.3 CCF47794.1 - 0.098 12.7 0.1 0.11 12.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) DUF4381 PF14316.1 CCF47794.1 - 0.14 12.2 0.0 0.16 12.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Pyridox_oxidase PF01243.15 CCF47795.1 - 2.9e-05 23.9 0.0 0.00013 21.8 0.0 1.9 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase zf-C2H2_4 PF13894.1 CCF47797.1 - 0.0027 17.9 13.1 0.78 10.2 0.2 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.21 CCF47797.1 - 0.21 11.9 14.0 1.1 9.7 0.1 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type Abhydrolase_5 PF12695.2 CCF47798.1 - 1.2e-14 54.2 0.1 2.3e-14 53.3 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family PAF-AH_p_II PF03403.8 CCF47798.1 - 1.6e-14 53.0 0.0 1.4e-06 26.8 0.0 2.8 2 1 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_6 PF12697.2 CCF47798.1 - 1.6e-08 34.7 1.2 1.6e-08 34.7 0.8 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 CCF47798.1 - 1.1e-06 27.7 0.0 4.3e-06 25.7 0.0 1.8 1 1 1 2 2 2 1 Chlorophyllase enzyme Chlorophyllase PF07224.6 CCF47798.1 - 0.0063 15.3 0.0 0.019 13.7 0.0 1.6 1 1 0 1 1 1 1 Chlorophyllase Abhydrolase_2 PF02230.11 CCF47798.1 - 0.024 14.0 0.0 0.034 13.5 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.16 CCF47798.1 - 0.03 13.5 0.0 0.054 12.7 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Fungal_trans_2 PF11951.3 CCF47799.1 - 1.2e-07 30.6 4.0 2.1e-07 29.9 2.8 1.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CCF47799.1 - 0.062 13.2 1.9 0.12 12.3 1.3 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.11 CCF47800.1 - 7.3e-06 24.9 9.5 9.7e-06 24.5 6.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.2 CCF47800.1 - 0.0005 19.8 0.1 0.00082 19.1 0.1 1.3 1 0 0 1 1 1 1 MFS_1 like family ATG22 PF11700.3 CCF47800.1 - 0.0062 15.0 0.0 0.0084 14.6 0.0 1.2 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like Xan_ur_permease PF00860.15 CCF47801.1 - 4.3e-12 45.2 4.8 4.3e-12 45.2 3.3 2.5 3 0 0 3 3 3 2 Permease family Hyd_WA PF06462.7 CCF47804.1 - 0.18 11.4 0.4 0.32 10.6 0.0 1.8 2 0 0 2 2 2 0 Propeller Peptidase_S8 PF00082.17 CCF47806.1 - 1.4e-42 145.7 5.3 2.2e-42 145.1 2.4 2.0 2 0 0 2 2 2 1 Subtilase family PA PF02225.17 CCF47806.1 - 2.1e-08 33.7 0.0 6.3e-08 32.2 0.0 1.9 1 0 0 1 1 1 1 PA domain DUF1034 PF06280.7 CCF47806.1 - 5.6e-08 33.1 0.0 1.3e-07 32.0 0.0 1.7 1 0 0 1 1 1 1 Fn3-like domain (DUF1034) Inhibitor_I9 PF05922.11 CCF47806.1 - 0.14 12.7 0.0 0.27 11.8 0.0 1.5 1 0 0 1 1 1 0 Peptidase inhibitor I9 Sugar_tr PF00083.19 CCF47807.1 - 1.3e-71 241.5 25.6 1.5e-71 241.2 17.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF47807.1 - 1.6e-20 73.1 22.6 1.6e-20 73.1 15.6 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3687 PF12459.3 CCF47807.1 - 0.045 12.9 1.2 0.093 11.9 0.1 2.1 2 0 0 2 2 2 0 D-Ala-teichoic acid biosynthesis protein LysM PF01476.15 CCF47809.1 - 1.3e-15 57.0 0.2 2e-06 27.5 0.0 2.6 2 2 0 2 2 2 2 LysM domain Rubella_E2 PF05749.6 CCF47809.1 - 0.1 11.8 4.8 0.11 11.7 3.3 1.1 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 RP-C_C PF11800.3 CCF47810.1 - 0.12 12.0 0.6 0.14 11.8 0.4 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region Dicty_REP PF05086.7 CCF47810.1 - 0.81 7.3 4.2 0.74 7.4 2.9 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Mucin PF01456.12 CCF47810.1 - 1 9.1 8.6 1.2 8.9 6.0 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Pex14_N PF04695.8 CCF47810.1 - 2.5 8.1 6.9 2.9 7.9 4.8 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region WSC PF01822.14 CCF47811.1 - 0.064 13.1 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 WSC domain DUF1996 PF09362.5 CCF47812.1 - 2.4e-53 181.2 0.2 3e-53 180.9 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) Tox-PL PF15644.1 CCF47813.1 - 0.12 13.1 0.0 0.15 12.8 0.0 1.1 1 0 0 1 1 1 0 Papain fold toxin 1 Pkinase PF00069.20 CCF47814.1 - 7.4e-22 77.7 0.0 1.6e-21 76.6 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF47814.1 - 3.5e-07 29.5 0.0 1e-06 28.0 0.0 1.7 2 1 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 CCF47814.1 - 0.014 15.1 0.2 0.19 11.4 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family DDE_1 PF03184.14 CCF47815.1 - 2.6e-10 39.7 0.0 3.6e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease zf-CCHC PF00098.18 CCF47815.1 - 0.068 13.1 5.5 0.14 12.1 3.8 1.5 1 0 0 1 1 1 0 Zinc knuckle DUF2205 PF10224.4 CCF47815.1 - 0.092 12.3 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) p450 PF00067.17 CCF47816.1 - 2.4e-16 59.3 0.0 3.2e-16 58.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HET PF06985.6 CCF47819.1 - 1.5e-21 77.0 7.3 1.4e-19 70.6 5.1 2.3 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) MMR_HSR1 PF01926.18 CCF47822.1 - 1.1e-17 64.0 0.2 2.1e-15 56.6 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CCF47822.1 - 1.5e-07 30.8 0.5 2e-05 23.8 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B DUF258 PF03193.11 CCF47822.1 - 0.00015 21.0 0.0 0.00027 20.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 CCF47822.1 - 0.0013 18.6 0.9 0.024 14.4 0.0 2.8 3 0 0 3 3 3 1 Dynamin family AIG1 PF04548.11 CCF47822.1 - 0.0099 15.0 0.1 0.018 14.1 0.0 1.4 1 0 0 1 1 1 1 AIG1 family Miro PF08477.8 CCF47822.1 - 0.028 14.9 0.0 0.074 13.5 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein Rep_fac_C PF08542.6 CCF47823.1 - 3.2e-19 68.6 0.0 7.4e-19 67.5 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 CCF47823.1 - 1e-11 44.7 0.0 8.1e-10 38.5 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.24 CCF47823.1 - 2.5e-11 43.8 0.0 4.8e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 CCF47823.1 - 1.9e-07 31.0 0.0 4e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CCF47823.1 - 2.8e-06 27.4 0.1 0.00011 22.2 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 CCF47823.1 - 1.5e-05 25.1 0.1 0.0045 17.1 0.1 2.6 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 CCF47823.1 - 2e-05 23.7 0.0 6.9e-05 22.0 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus Rad17 PF03215.10 CCF47823.1 - 4.3e-05 22.4 0.0 0.021 13.5 0.0 2.5 2 1 0 2 2 2 2 Rad17 cell cycle checkpoint protein Viral_helicase1 PF01443.13 CCF47823.1 - 0.00011 21.8 0.0 0.00017 21.1 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_10 PF12846.2 CCF47823.1 - 0.00019 20.9 0.0 0.045 13.1 0.0 2.3 1 1 1 2 2 2 1 AAA-like domain AAA_3 PF07726.6 CCF47823.1 - 0.00022 20.8 0.0 0.00042 19.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 CCF47823.1 - 0.0011 18.3 0.1 0.12 11.7 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CCF47823.1 - 0.0021 17.7 0.0 0.0048 16.6 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain DEAD PF00270.24 CCF47823.1 - 0.0027 17.2 0.1 0.11 11.9 0.0 2.5 1 1 1 2 2 2 1 DEAD/DEAH box helicase DNA_pol3_delta PF06144.8 CCF47823.1 - 0.0029 17.1 0.0 0.0049 16.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Mg_chelatase PF01078.16 CCF47823.1 - 0.0043 16.2 0.0 0.039 13.1 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.10 CCF47823.1 - 0.0047 16.6 0.5 0.031 13.9 0.1 2.3 2 1 1 3 3 2 1 NTPase FtsK_SpoIIIE PF01580.13 CCF47823.1 - 0.0058 16.1 0.0 0.012 15.0 0.0 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family ArgK PF03308.11 CCF47823.1 - 0.0062 15.3 0.0 0.016 14.0 0.0 1.6 1 1 0 1 1 1 1 ArgK protein AAA_11 PF13086.1 CCF47823.1 - 0.0077 15.8 0.1 0.014 15.0 0.0 1.3 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 CCF47823.1 - 0.013 14.7 0.0 0.024 13.8 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_31 PF13614.1 CCF47823.1 - 0.013 15.3 0.0 0.054 13.4 0.0 2.0 1 1 0 2 2 2 0 AAA domain AAA_18 PF13238.1 CCF47823.1 - 0.015 15.6 0.0 0.03 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain DNA_pol3_gamma3 PF12169.3 CCF47823.1 - 0.03 14.0 0.2 0.57 9.9 0.0 2.6 3 0 0 3 3 3 0 DNA polymerase III subunits gamma and tau domain III AAA_5 PF07728.9 CCF47823.1 - 0.036 13.8 0.1 0.28 10.8 0.0 2.4 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.17 CCF47823.1 - 0.088 11.6 0.0 0.16 10.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain UreF PF01730.11 CCF47825.1 - 3.4e-13 49.9 0.6 6.1e-13 49.1 0.4 1.4 1 0 0 1 1 1 1 UreF RRM_1 PF00076.17 CCF47826.1 - 3.1e-08 33.1 0.0 5.3e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CCF47826.1 - 1e-07 31.7 0.0 2.1e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CCF47826.1 - 4.7e-05 23.0 0.0 9.9e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_6 PF14259.1 CCF47826.1 - 7.3e-05 22.6 0.0 0.00013 21.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.19 CCF47826.1 - 0.014 15.0 0.7 0.031 13.9 0.5 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TGS PF02824.16 CCF47827.1 - 2.8e-19 68.7 0.0 4.9e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.18 CCF47827.1 - 5.7e-19 68.1 0.0 1.5e-18 66.8 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CCF47827.1 - 1.1e-12 47.5 0.0 1.8e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 CCF47827.1 - 2e-05 24.4 0.3 0.022 14.5 0.0 2.5 1 1 1 2 2 2 2 Dynamin family Miro PF08477.8 CCF47827.1 - 0.0021 18.5 0.0 0.0054 17.2 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein ArgK PF03308.11 CCF47827.1 - 0.047 12.4 0.2 0.17 10.6 0.1 1.9 2 1 0 2 2 2 0 ArgK protein DUF2009 PF09418.5 CCF47827.1 - 0.074 11.8 0.2 0.1 11.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) MCM PF00493.18 CCF47827.1 - 0.084 11.6 0.0 0.17 10.6 0.0 1.4 1 0 0 1 1 1 0 MCM2/3/5 family adh_short PF00106.20 CCF47828.1 - 5.6e-13 49.1 5.6 6.2e-13 48.9 3.9 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CCF47828.1 - 5e-07 29.7 0.1 5.8e-07 29.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CCF47828.1 - 3.9e-06 26.6 3.1 4.5e-06 26.4 2.2 1.0 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 CCF47828.1 - 3.6e-05 22.8 0.1 3.9e-05 22.7 0.1 1.0 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3HCDH_N PF02737.13 CCF47828.1 - 0.00017 21.3 1.5 0.0002 21.0 1.1 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.16 CCF47828.1 - 0.0002 20.8 0.5 0.00024 20.6 0.3 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.13 CCF47828.1 - 0.0024 17.8 0.6 0.0031 17.5 0.4 1.2 1 0 0 1 1 1 1 TrkA-N domain UDPG_MGDP_dh_N PF03721.9 CCF47828.1 - 0.0055 16.0 0.2 0.0061 15.9 0.2 1.1 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AdoHcyase_NAD PF00670.16 CCF47828.1 - 0.015 15.1 1.7 0.015 15.1 1.2 1.2 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Urocanase PF01175.13 CCF47828.1 - 0.016 13.2 0.1 0.018 13.1 0.1 1.0 1 0 0 1 1 1 0 Urocanase 3Beta_HSD PF01073.14 CCF47828.1 - 0.029 13.0 0.1 0.035 12.8 0.1 1.0 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Shikimate_DH PF01488.15 CCF47828.1 - 0.061 13.4 0.5 0.068 13.2 0.4 1.2 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 CCF47828.1 - 0.067 13.1 3.2 0.096 12.6 2.2 1.3 1 1 0 1 1 1 0 NADH(P)-binding Ldh_1_N PF00056.18 CCF47828.1 - 0.071 12.9 0.5 0.079 12.7 0.3 1.1 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.14 CCF47828.1 - 0.088 11.9 0.6 0.21 10.7 0.2 1.6 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_16 PF10294.4 CCF47828.1 - 0.11 11.9 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 Putative methyltransferase DapB_N PF01113.15 CCF47828.1 - 0.15 12.0 2.1 0.29 11.0 1.5 1.5 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DFP PF04127.10 CCF47828.1 - 0.17 11.4 1.4 0.26 10.8 1.0 1.4 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Fibrillarin PF01269.12 CCF47829.1 - 8.6e-57 191.6 0.0 1.1e-56 191.2 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.5 CCF47829.1 - 0.12 11.8 0.1 0.17 11.3 0.1 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Suf PF05843.9 CCF47830.1 - 0.0047 16.7 6.4 0.0053 16.5 4.4 1.2 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Spt20 PF12090.3 CCF47830.1 - 0.0067 15.7 1.5 0.0082 15.5 1.1 1.2 1 0 0 1 1 1 1 Spt20 family PAT1 PF09770.4 CCF47830.1 - 0.014 13.7 31.9 0.015 13.5 22.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4557 PF15101.1 CCF47830.1 - 0.036 13.9 5.3 0.043 13.6 3.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Pex14_N PF04695.8 CCF47830.1 - 0.19 11.7 10.4 0.32 11.0 7.2 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Zip PF02535.17 CCF47830.1 - 0.2 10.6 0.6 0.24 10.3 0.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter TFIIA PF03153.8 CCF47830.1 - 0.59 9.9 15.2 0.72 9.6 10.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF605 PF04652.11 CCF47830.1 - 2 7.7 16.6 2.3 7.5 11.5 1.1 1 0 0 1 1 1 0 Vta1 like CVNH PF08881.5 CCF47831.1 - 3.1e-20 72.3 0.2 3.3e-20 72.2 0.1 1.0 1 0 0 1 1 1 1 CVNH domain Mtc PF03820.12 CCF47832.1 - 5.5e-103 343.8 0.1 4.3e-102 340.8 0.1 1.9 1 1 0 1 1 1 1 Tricarboxylate carrier zinc_ribbon_5 PF13719.1 CCF47833.1 - 0.039 13.5 0.3 0.083 12.4 0.2 1.5 1 0 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 CCF47833.1 - 0.053 13.2 0.5 0.11 12.1 0.3 1.5 1 0 0 1 1 1 0 zinc-ribbon domain DUF2407 PF10302.4 CCF47835.1 - 1.4e-27 95.7 0.0 2.4e-27 94.9 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain DUF2407_C PF13373.1 CCF47835.1 - 2e-07 31.0 0.3 2.9e-07 30.4 0.2 1.3 1 0 0 1 1 1 1 DUF2407 C-terminal domain ubiquitin PF00240.18 CCF47835.1 - 0.0021 17.3 0.0 0.0054 16.1 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD_2 PF13881.1 CCF47835.1 - 0.029 14.2 0.0 0.057 13.3 0.0 1.5 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Glyco_hydro_3 PF00933.16 CCF47836.1 - 1.8e-56 191.3 0.0 2e-56 191.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 CCF47839.1 - 7.3e-49 166.3 0.3 1.2e-47 162.3 0.1 2.2 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.16 CCF47839.1 - 1.5e-44 152.2 0.0 1.9e-44 151.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.1 CCF47839.1 - 2.6e-25 88.1 0.1 4.8e-25 87.2 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain CARDB PF07705.6 CCF47839.1 - 0.016 15.2 0.0 0.048 13.7 0.0 1.8 1 0 0 1 1 1 0 CARDB Nucleoplasmin PF03066.10 CCF47840.1 - 0.0077 15.7 8.3 0.011 15.1 5.7 1.3 1 0 0 1 1 1 1 Nucleoplasmin TRAP_alpha PF03896.11 CCF47840.1 - 0.029 13.3 0.8 0.043 12.8 0.6 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit NOA36 PF06524.7 CCF47840.1 - 0.076 12.2 13.0 0.077 12.2 8.0 1.7 2 0 0 2 2 2 0 NOA36 protein Nop14 PF04147.7 CCF47840.1 - 2 6.2 8.1 2.5 5.9 5.6 1.1 1 0 0 1 1 1 0 Nop14-like family Daxx PF03344.10 CCF47840.1 - 8 4.8 11.1 11 4.3 7.7 1.1 1 0 0 1 1 1 0 Daxx Family Ribosomal_L34 PF00468.12 CCF47841.1 - 4.1e-14 51.9 11.4 8.2e-14 51.0 7.9 1.5 1 0 0 1 1 1 1 Ribosomal protein L34 Peptidase_M48 PF01435.13 CCF47842.1 - 3.1e-50 170.8 0.2 4.5e-50 170.3 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.6 CCF47842.1 - 0.037 12.9 0.0 0.078 11.9 0.0 1.6 1 0 0 1 1 1 0 BlaR1 peptidase M56 DUF2201_N PF13203.1 CCF47842.1 - 0.043 12.9 0.3 0.091 11.9 0.2 1.4 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF955 PF06114.8 CCF47842.1 - 0.13 11.9 0.5 1 9.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF955) Ish1 PF10281.4 CCF47843.1 - 0.00012 22.0 0.0 0.00016 21.6 0.0 1.2 1 0 0 1 1 1 1 Putative stress-responsive nuclear envelope protein Ribosomal_L38e PF01781.13 CCF47844.1 - 4.3e-33 112.8 2.0 5e-33 112.6 1.4 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family PYST-C1 PF09690.5 CCF47844.1 - 0.2 11.3 0.5 0.2 11.3 0.3 1.7 2 0 0 2 2 2 0 Plasmodium yoelii subtelomeric region (PYST-C1) NRPS PF08415.5 CCF47845.1 - 0.037 13.8 1.8 0.085 12.6 1.3 1.6 1 0 0 1 1 1 0 Nonribosomal peptide synthase CX PF01705.14 CCF47845.1 - 1.6 8.7 12.9 3.2 7.8 1.0 3.5 3 0 0 3 3 3 0 CX module ubiquitin PF00240.18 CCF47846.1 - 1.3e-19 69.3 0.1 2e-19 68.7 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 CCF47846.1 - 0.00011 21.8 0.1 0.00017 21.2 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.1 CCF47846.1 - 0.00013 21.8 0.0 0.0002 21.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 CCF47846.1 - 0.051 13.7 0.0 0.08 13.1 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Fungal_trans_2 PF11951.3 CCF47848.1 - 5.1e-05 22.0 0.6 0.0003 19.5 0.0 2.0 2 0 0 2 2 2 2 Fungal specific transcription factor domain Ketoacyl-synt_C PF02801.17 CCF47849.1 - 2e-39 134.0 0.0 3.2e-39 133.4 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.21 CCF47849.1 - 1.9e-09 37.4 0.1 5e-09 36.0 0.0 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Melibiase PF02065.13 CCF47850.1 - 0.0048 15.6 1.5 0.68 8.5 0.0 2.4 2 1 0 2 2 2 2 Melibiase Sugar_tr PF00083.19 CCF47851.1 - 5.6e-92 308.6 28.7 6.5e-92 308.4 19.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CCF47851.1 - 8.1e-26 90.5 52.8 4.7e-23 81.4 17.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily COesterase PF00135.23 CCF47852.1 - 5e-64 216.9 4.1 1.2e-63 215.6 2.8 1.6 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 CCF47852.1 - 0.00077 19.0 0.2 0.0072 15.9 0.1 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold AAA PF00004.24 CCF47853.1 - 8.5e-13 48.6 0.0 1.6e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CCF47853.1 - 0.00035 20.5 0.4 0.0014 18.6 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 CCF47853.1 - 0.00045 21.0 0.1 0.003 18.3 0.0 2.4 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.1 CCF47853.1 - 0.00096 19.2 0.1 0.017 15.2 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.1 CCF47853.1 - 0.0015 18.2 0.0 0.004 16.8 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 CCF47853.1 - 0.019 14.6 0.1 0.037 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 CCF47853.1 - 0.031 14.5 0.0 0.093 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 CCF47853.1 - 0.035 13.9 0.0 0.16 11.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain KaiC PF06745.8 CCF47853.1 - 0.039 13.0 0.1 0.062 12.4 0.1 1.3 1 0 0 1 1 1 0 KaiC ArgK PF03308.11 CCF47853.1 - 0.046 12.4 0.0 0.079 11.7 0.0 1.2 1 0 0 1 1 1 0 ArgK protein AAA_2 PF07724.9 CCF47853.1 - 0.053 13.4 0.0 0.09 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Zot PF05707.7 CCF47853.1 - 0.07 12.5 0.1 11 5.3 0.0 2.4 1 1 0 2 2 2 0 Zonular occludens toxin (Zot) NTPase_1 PF03266.10 CCF47853.1 - 0.072 12.8 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 NTPase Mg_chelatase PF01078.16 CCF47853.1 - 2.5 7.2 4.0 1.2 8.2 0.1 2.4 2 1 0 3 3 3 0 Magnesium chelatase, subunit ChlI 2-Hacid_dh_C PF02826.14 CCF47855.1 - 1.4e-43 148.1 0.0 1.5e-43 147.9 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.10 CCF47855.1 - 2.3e-05 24.3 0.0 2.9e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.7 CCF47855.1 - 0.038 13.3 0.0 0.046 13.0 0.0 1.1 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain UDPG_MGDP_dh_C PF03720.10 CCF47855.1 - 0.053 13.6 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Methyltransf_23 PF13489.1 CCF47856.1 - 5.7e-05 22.8 0.0 0.00011 21.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CCF47856.1 - 0.092 13.2 0.0 0.2 12.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DUF1579 PF07617.6 CCF47857.1 - 0.033 13.8 0.1 0.036 13.7 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1579) Abhydrolase_6 PF12697.2 CCF47861.1 - 4.4e-18 65.9 0.0 5.1e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CCF47861.1 - 4.6e-09 36.1 0.0 6.4e-09 35.7 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CCF47861.1 - 1.5e-08 34.4 0.0 1.7e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ndr PF03096.9 CCF47861.1 - 0.0047 15.4 0.0 0.0062 15.0 0.0 1.1 1 0 0 1 1 1 1 Ndr family DUF3425 PF11905.3 CCF47862.1 - 6.4e-33 113.5 0.1 8.6e-33 113.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) p450 PF00067.17 CCF47863.1 - 2.1e-72 244.1 0.0 2.8e-72 243.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_7 PF00840.15 CCF47864.1 - 2.4e-188 625.9 12.4 2.8e-188 625.7 8.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 Pkinase PF00069.20 CCF47865.1 - 5.5e-66 222.3 0.0 7.6e-66 221.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF47865.1 - 2.3e-30 105.5 0.0 3e-30 105.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 CCF47865.1 - 0.00036 20.9 0.2 0.00075 19.9 0.1 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.18 CCF47865.1 - 0.15 11.7 0.1 1.9 8.1 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family MFS_1 PF07690.11 CCF47866.1 - 4e-27 94.8 32.6 4e-27 94.8 22.6 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CCF47866.1 - 1.7e-13 49.9 23.9 5.3e-13 48.3 16.5 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter Beta_elim_lyase PF01212.16 CCF47867.1 - 6e-63 212.6 0.0 7.6e-63 212.3 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 CCF47867.1 - 3.2e-05 22.8 0.0 4.3e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 CCF47867.1 - 4.1e-05 22.7 0.5 0.00014 21.0 0.3 1.8 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 CCF47867.1 - 5.9e-05 22.1 0.0 0.00011 21.2 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 CCF47867.1 - 0.00011 20.6 0.0 0.00018 19.8 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme WD40 PF00400.27 CCF47868.1 - 2e-48 160.5 19.2 1.3e-10 40.7 0.2 6.9 7 1 0 7 7 7 6 WD domain, G-beta repeat PRP4 PF08799.6 CCF47868.1 - 4.3e-14 51.4 2.0 7.5e-14 50.7 1.4 1.4 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Nbas_N PF15492.1 CCF47868.1 - 0.0044 16.1 0.1 0.87 8.6 0.0 2.5 3 0 0 3 3 3 2 Neuroblastoma-amplified sequence, N terminal eIF2A PF08662.6 CCF47868.1 - 0.051 13.2 0.0 4.5 6.9 0.0 3.3 2 1 2 5 5 5 0 Eukaryotic translation initiation factor eIF2A Cyclin_N PF00134.18 CCF47869.1 - 1.5e-08 34.2 0.4 0.0001 21.8 0.4 2.7 3 0 0 3 3 3 2 Cyclin, N-terminal domain TFIIB PF00382.14 CCF47869.1 - 0.13 12.1 0.2 0.22 11.3 0.1 1.3 1 0 0 1 1 1 0 Transcription factor TFIIB repeat WRW PF10206.4 CCF47869.1 - 0.15 12.1 0.2 1.1 9.3 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial F1F0-ATP synthase, subunit f Dus PF01207.12 CCF47870.1 - 7.4e-30 103.8 0.0 8.4e-26 90.5 0.0 2.4 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) SpoIIE PF07228.7 CCF47871.1 - 2.2e-09 37.3 0.1 4.2e-09 36.3 0.1 1.5 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 CCF47871.1 - 4.3e-08 32.8 0.3 8.3e-08 31.8 0.2 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.16 CCF47871.1 - 1e-07 31.6 0.1 0.012 15.0 0.0 2.4 2 0 0 2 2 2 2 Protein phosphatase 2C eIF-6 PF01912.13 CCF47872.1 - 2e-18 66.2 0.1 3.7e-18 65.3 0.1 1.4 2 0 0 2 2 2 1 eIF-6 family Macoilin PF09726.4 CCF47873.1 - 0.014 13.7 4.0 0.02 13.2 2.8 1.2 1 0 0 1 1 1 0 Transmembrane protein IncA PF04156.9 CCF47873.1 - 0.05 13.2 3.8 0.095 12.2 2.6 1.4 1 0 0 1 1 1 0 IncA protein Mnd1 PF03962.10 CCF47873.1 - 0.19 11.3 6.9 0.36 10.4 4.8 1.5 1 0 0 1 1 1 0 Mnd1 family Spc7 PF08317.6 CCF47873.1 - 0.3 9.6 7.7 0.53 8.8 5.3 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein APG6 PF04111.7 CCF47873.1 - 0.91 8.5 7.2 1.3 7.9 5.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF2570 PF10828.3 CCF47873.1 - 1.5 8.4 8.1 0.86 9.2 3.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) NDUF_B12 PF08122.7 CCF47874.1 - 2.1e-15 56.1 1.4 3.1e-15 55.6 1.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family CAF1 PF04857.15 CCF47875.1 - 2e-69 233.8 0.0 2.6e-69 233.4 0.0 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease RFX_DNA_binding PF02257.10 CCF47875.1 - 0.13 12.3 0.0 0.5 10.5 0.0 1.9 2 0 0 2 2 2 0 RFX DNA-binding domain LMBR1 PF04791.11 CCF47876.1 - 8e-22 77.4 11.8 2.6e-21 75.7 8.2 1.7 1 1 0 1 1 1 1 LMBR1-like membrane protein Phage_P2_GpE PF06528.7 CCF47876.1 - 0.069 12.6 0.1 0.18 11.2 0.1 1.7 1 0 0 1 1 1 0 Phage P2 GpE DUF2040 PF09745.4 CCF47877.1 - 1.5e-39 134.7 24.9 1.5e-39 134.7 17.3 3.3 2 1 1 3 3 3 3 Coiled-coil domain-containing protein 55 (DUF2040) zf-Tim10_DDP PF02953.10 CCF47878.1 - 6.7e-22 76.5 1.7 8e-22 76.3 1.2 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Lectin_leg-like PF03388.8 CCF47879.1 - 2.2e-66 223.2 0.0 2.8e-66 222.9 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Lectin_legB PF00139.14 CCF47879.1 - 0.0035 16.7 0.0 0.47 9.7 0.0 2.2 2 0 0 2 2 2 2 Legume lectin domain Pkinase PF00069.20 CCF47880.1 - 5.8e-72 241.9 0.6 1e-71 241.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CCF47880.1 - 1.3e-38 132.6 0.0 2.2e-38 131.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CCF47880.1 - 2.2e-08 33.4 0.3 6.9e-08 31.7 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 CCF47880.1 - 0.043 13.5 0.8 0.29 10.8 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF605 PF04652.11 CCF47880.1 - 0.055 12.8 35.1 0.075 12.4 24.3 1.1 1 0 0 1 1 1 0 Vta1 like PAT1 PF09770.4 CCF47880.1 - 0.51 8.5 44.5 0.81 7.8 30.9 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Serinc PF03348.10 CCF47880.1 - 2.5 6.7 3.5 3.8 6.1 2.4 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4407 PF14362.1 CCF47880.1 - 2.7 6.8 8.0 4.4 6.1 5.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TFIIA PF03153.8 CCF47880.1 - 4.6 7.0 34.3 6.4 6.5 23.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.7 CCF47880.1 - 4.7 7.0 8.2 7.5 6.3 5.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CorA PF01544.13 CCF47881.1 - 1.7e-05 23.9 1.0 3.2e-05 23.1 0.4 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein COX16 PF14138.1 CCF47881.1 - 0.0016 18.5 0.0 0.37 10.9 0.0 3.1 3 0 0 3 3 3 2 Cytochrome c oxidase assembly protein COX16 PI-PLC-X PF00388.14 CCF47882.1 - 1.1e-61 206.5 0.0 1.7e-61 205.9 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 CCF47882.1 - 3.5e-36 123.7 0.0 6.3e-36 122.9 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.6 CCF47882.1 - 0.015 15.3 0.0 0.052 13.5 0.0 1.9 1 1 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like