# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- VSP PF03302.13 EFO60770.1 - 7.2e-17 61.3 156.2 0.00028 19.9 48.6 4.8 1 1 2 4 4 4 4 Giardia variant-specific surface protein DUF4705 PF15788.5 EFO60770.1 - 0.071 13.4 4.7 0.33 11.2 4.7 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4705) Ank_2 PF12796.7 EFO60772.1 - 2.5e-21 76.1 0.1 1.5e-11 44.7 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO60772.1 - 3e-14 53.2 0.0 0.00027 21.4 0.0 3.3 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO60772.1 - 3.7e-14 52.6 0.5 0.0053 17.0 0.0 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60772.1 - 9.1e-10 37.9 0.2 0.51 11.1 0.0 4.8 3 1 1 4 4 4 3 Ankyrin repeat Ank PF00023.30 EFO60772.1 - 1.7e-08 34.5 0.0 0.34 11.5 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 EFO60773.1 - 2.9e-47 159.1 7.6 6.6e-17 61.9 0.1 5.1 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO60773.1 - 3.5e-33 115.1 0.0 7.9e-33 113.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 EFO60773.1 - 5.4e-31 106.6 3.0 1.3e-06 28.8 0.0 7.8 5 2 4 9 9 9 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60773.1 - 2.5e-27 91.9 5.2 0.0077 16.7 0.0 9.7 9 0 0 9 9 9 7 Ankyrin repeat Ank_5 PF13857.6 EFO60773.1 - 6.1e-25 87.0 9.2 0.00031 21.0 0.0 7.7 2 2 4 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO60773.1 - 1.7e-21 75.6 8.1 0.0018 18.7 0.0 8.4 9 0 0 9 9 9 6 Ankyrin repeat Pkinase_Tyr PF07714.17 EFO60773.1 - 2.7e-21 76.0 0.0 4.3e-21 75.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase CENP-F_leu_zip PF10473.9 EFO60773.1 - 0.2 11.7 8.1 0.42 10.6 8.1 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3764 PF12594.8 EFO60773.1 - 0.21 11.6 0.5 6 7.0 0.0 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF3764) RVT_1 PF00078.27 EFO60774.1 - 7.9e-05 22.3 0.0 0.0001 21.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ank_2 PF12796.7 EFO60775.1 - 9.7e-62 205.5 0.2 1.9e-16 60.4 0.0 5.2 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 EFO60775.1 - 5.4e-44 146.8 3.1 0.00022 21.5 0.0 10.1 10 0 0 10 10 10 9 Ankyrin repeat Ank_4 PF13637.6 EFO60775.1 - 8.3e-41 137.9 0.5 6.5e-10 39.4 0.0 7.1 6 2 1 7 7 7 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO60775.1 - 8.6e-39 131.1 6.0 5.6e-08 32.9 0.0 8.8 2 2 7 9 9 9 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60775.1 - 6.9e-38 124.3 0.1 0.0012 19.1 0.0 10.1 10 0 0 10 10 10 9 Ankyrin repeat HemY_N PF07219.13 EFO60775.1 - 0.12 12.5 2.1 0.38 11.0 0.8 2.5 2 0 0 2 2 2 0 HemY protein N-terminus 3HCDH_RFF PF18321.1 EFO60775.1 - 0.47 10.9 5.0 23 5.5 0.0 4.5 5 1 0 5 5 5 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain VSP PF03302.13 EFO60776.1 - 5e-72 242.9 108.1 2e-38 132.3 28.3 3.0 1 1 2 3 3 3 3 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO60776.1 - 8.7e-09 35.5 73.5 0.00048 20.3 2.3 6.6 1 1 5 6 6 6 5 Furin-like repeat, cysteine-rich Podoplanin PF05808.11 EFO60776.1 - 0.0023 18.0 0.8 0.0037 17.4 0.1 1.6 2 0 0 2 2 2 1 Podoplanin VSP PF03302.13 EFO60778.1 - 1.9e-86 290.4 144.8 5.3e-51 173.7 33.0 5.6 1 1 5 6 6 6 4 Giardia variant-specific surface protein SM-ATX PF14438.6 EFO60778.1 - 0.19 11.9 0.0 0.61 10.3 0.0 1.8 2 0 0 2 2 2 0 Ataxin 2 SM domain SKG6 PF08693.10 EFO60778.1 - 0.22 11.0 4.5 0.43 10.0 4.5 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Podoplanin PF05808.11 EFO60778.1 - 1.7 8.7 4.5 3.9 7.6 4.5 1.7 1 1 0 1 1 1 0 Podoplanin RVT_1 PF00078.27 EFO60779.1 - 1.8e-17 63.6 0.0 3.4e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GP120 PF00516.18 EFO60780.1 - 0.047 12.3 0.1 0.075 11.6 0.1 1.2 1 0 0 1 1 1 0 Envelope glycoprotein GP120 MCU PF04678.13 EFO60781.1 - 7 6.7 7.5 12 5.9 5.1 2.4 2 0 0 2 2 2 0 Mitochondrial calcium uniporter CBF PF03914.17 EFO60781.1 - 7.5 6.6 7.6 33 4.5 7.6 2.2 1 1 0 1 1 1 0 CBF/Mak21 family BRO1 PF03097.18 EFO60782.1 - 1.3e-12 47.2 3.6 1.3e-12 47.2 3.6 2.1 3 0 0 3 3 3 1 BRO1-like domain SPACA9 PF15120.6 EFO60782.1 - 0.0074 16.1 0.4 0.046 13.5 0.0 2.5 2 0 0 2 2 2 1 Sperm acrosome-associated protein 9 Laminin_II PF06009.12 EFO60782.1 - 0.25 11.3 6.0 4.8 7.2 0.9 3.4 3 0 0 3 3 3 0 Laminin Domain II Occludin_ELL PF07303.13 EFO60782.1 - 6.3 7.6 8.3 12 6.7 0.8 3.6 3 0 0 3 3 3 0 Occludin homology domain Peptidase_M30 PF10460.9 EFO60783.1 - 0.02 13.9 0.0 0.024 13.6 0.0 1.2 1 0 0 1 1 1 0 Peptidase M30 MOLO1 PF17175.4 EFO60783.1 - 0.13 12.3 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Modulator of levamisole receptor-1 Ank_2 PF12796.7 EFO60784.1 - 5.7e-63 209.5 17.8 7.8e-15 55.2 0.3 6.2 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO60784.1 - 9.9e-58 195.6 0.0 2.7e-57 194.1 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO60784.1 - 5.1e-33 114.4 0.0 1.7e-32 112.7 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Ank_5 PF13857.6 EFO60784.1 - 5.2e-32 109.5 8.9 1.1e-05 25.6 0.0 8.5 3 3 6 9 9 9 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO60784.1 - 3e-30 104.2 8.6 0.00061 20.3 0.0 9.5 6 3 3 9 9 9 8 Ankyrin repeats (many copies) Ank PF00023.30 EFO60784.1 - 5.6e-30 102.5 7.0 0.00057 20.2 0.1 10.2 10 0 0 10 10 10 6 Ankyrin repeat Ank_3 PF13606.6 EFO60784.1 - 2.1e-27 92.1 2.8 0.0026 18.1 0.0 10.6 11 0 0 11 11 11 6 Ankyrin repeat Pkinase_fungal PF17667.1 EFO60784.1 - 0.0025 16.7 0.0 0.0041 15.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EFO60784.1 - 0.0097 14.9 0.2 0.015 14.3 0.2 1.2 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase 3HCDH_RFF PF18321.1 EFO60784.1 - 0.03 14.8 9.7 4.1 7.9 0.1 5.8 6 0 0 6 6 6 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain Kinase-like PF14531.6 EFO60784.1 - 0.032 13.6 0.0 0.084 12.2 0.0 1.7 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EFO60784.1 - 0.039 13.9 0.0 0.07 13.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF2098 PF09871.9 EFO60784.1 - 0.061 13.7 0.2 0.16 12.3 0.2 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) PK_C PF02887.16 EFO60784.1 - 0.082 13.2 2.9 1.6 9.0 1.4 3.3 2 1 1 3 3 3 0 Pyruvate kinase, alpha/beta domain ABC1 PF03109.16 EFO60784.1 - 0.14 12.3 0.0 0.38 10.9 0.0 1.7 1 0 0 1 1 1 0 ABC1 family Nitrate_red_gam PF02665.14 EFO60784.1 - 0.21 11.1 0.6 0.42 10.1 0.6 1.4 1 0 0 1 1 1 0 Nitrate reductase gamma subunit Mt_ATP_synt PF15704.5 EFO60784.1 - 4.1 7.3 4.9 11 5.8 0.1 3.5 3 2 1 4 4 4 0 Mitochondrial ATP synthase subunit AAA_12 PF13087.6 EFO60786.1 - 4.4e-15 55.8 0.0 1.3e-14 54.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EFO60786.1 - 3.4e-12 46.7 0.0 1.3e-05 25.1 0.0 2.6 2 1 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 EFO60786.1 - 1e-06 28.7 0.2 0.042 13.6 0.0 3.4 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 EFO60786.1 - 1e-05 25.4 0.0 0.032 13.9 0.0 2.8 3 0 0 3 3 3 2 AAA domain AAA_19 PF13245.6 EFO60786.1 - 0.00024 21.5 0.0 0.0047 17.3 0.0 2.5 1 1 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 EFO60786.1 - 0.00061 19.6 0.0 0.0013 18.5 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 EFO60786.1 - 0.024 14.9 0.0 0.44 10.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFO60786.1 - 0.086 13.4 0.0 0.2 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 EFO60786.1 - 0.097 12.6 0.1 0.84 9.5 0.0 2.3 3 0 0 3 3 3 0 P-loop Nucleotide Kinase3 AAA_16 PF13191.6 EFO60786.1 - 0.2 12.0 1.0 3.5 8.0 0.0 2.9 3 0 0 3 3 3 0 AAA ATPase domain Ank_2 PF12796.7 EFO60787.1 - 6.2e-54 180.5 10.6 2.2e-11 44.2 0.3 6.3 2 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO60787.1 - 2.9e-34 116.7 4.8 7.9e-07 29.2 0.0 9.3 3 2 7 10 10 10 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO60787.1 - 4.2e-28 97.3 6.5 0.0011 19.5 0.0 9.1 7 3 1 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60787.1 - 1.6e-27 92.5 4.0 0.065 13.8 0.0 10.8 11 0 0 11 11 11 6 Ankyrin repeat Ank PF00023.30 EFO60787.1 - 8.4e-25 86.1 9.8 0.015 15.7 0.0 10.1 11 0 0 11 11 11 7 Ankyrin repeat HBS1_N PF08938.10 EFO60787.1 - 0.0061 16.8 0.1 0.02 15.2 0.1 1.9 1 0 0 1 1 1 1 HBS1 N-terminus ABC_tran PF00005.27 EFO60788.1 - 8.1e-43 146.2 0.0 5.9e-24 85.1 0.0 3.1 3 0 0 3 3 3 2 ABC transporter ABC_membrane PF00664.23 EFO60788.1 - 3.5e-27 95.7 44.8 2.7e-19 69.9 11.8 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EFO60788.1 - 3.8e-14 52.6 0.0 0.00026 20.5 0.0 3.6 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFO60788.1 - 9.8e-07 28.9 0.1 0.39 10.5 0.0 4.2 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EFO60788.1 - 6.7e-05 22.9 0.1 0.01 15.9 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 EFO60788.1 - 0.00025 21.6 0.7 0.83 10.1 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EFO60788.1 - 0.00042 20.7 0.5 0.25 11.7 0.1 2.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EFO60788.1 - 0.0011 18.7 0.4 0.11 12.3 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF87 PF01935.17 EFO60788.1 - 0.0012 19.0 1.3 0.05 13.7 0.0 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_22 PF13401.6 EFO60788.1 - 0.0045 17.3 0.3 2 8.7 0.0 3.4 3 0 0 3 3 3 1 AAA domain TsaE PF02367.17 EFO60788.1 - 0.023 14.7 0.3 17 5.4 0.0 3.4 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EFO60788.1 - 0.023 14.2 0.1 4.4 6.8 0.0 2.7 3 0 0 3 3 3 0 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EFO60788.1 - 0.03 14.2 0.1 0.54 10.1 0.0 2.6 2 0 0 2 2 2 0 RsgA GTPase ATP-synt_ab PF00006.25 EFO60788.1 - 0.036 13.7 0.0 9.3 5.8 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_25 PF13481.6 EFO60788.1 - 0.099 12.2 0.0 8.9 5.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFO60788.1 - 5.2 7.2 4.7 46 4.1 0.1 3.4 3 1 0 3 3 3 0 AAA domain Alanine_zipper PF11839.8 EFO60789.1 - 0.012 15.9 3.4 0.012 15.9 3.4 5.6 4 1 1 5 5 5 0 Alanine-zipper, major outer membrane lipoprotein NPV_P10 PF05531.12 EFO60789.1 - 2.1 8.9 22.7 28 5.3 2.0 7.8 7 1 1 8 8 8 0 Nucleopolyhedrovirus P10 protein Ank_2 PF12796.7 EFO60791.1 - 6.6e-09 36.3 0.9 7.9e-06 26.4 0.4 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFO60791.1 - 2.7e-05 24.4 4.1 0.00057 20.2 0.7 3.5 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 EFO60791.1 - 4.8e-05 23.4 0.5 0.088 13.4 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EFO60791.1 - 0.00069 20.1 0.0 0.32 11.6 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO60791.1 - 0.0059 16.9 1.3 0.074 13.4 0.2 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) CSRNP_N PF16019.5 EFO60792.1 - 0.0099 15.8 1.2 0.018 15.0 1.2 1.4 1 0 0 1 1 1 1 Cysteine/serine-rich nuclear protein N-terminus Epimerase PF01370.21 EFO60793.1 - 2.6e-51 174.4 0.0 2.9e-51 174.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFO60793.1 - 1.4e-47 162.7 0.0 2e-47 162.3 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EFO60793.1 - 9.5e-17 60.9 0.0 1.3e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EFO60793.1 - 4.1e-13 49.1 0.0 1.4e-12 47.3 0.0 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EFO60793.1 - 1.2e-10 41.0 0.3 2.8e-08 33.3 0.3 2.6 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 EFO60793.1 - 3.4e-07 29.7 0.0 4.3e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 EFO60793.1 - 0.003 17.0 0.0 0.0063 16.0 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase NUDIX PF00293.28 EFO60795.1 - 1.7e-10 41.0 0.0 4.1e-10 39.8 0.0 1.6 2 0 0 2 2 2 1 NUDIX domain ParA PF10609.9 EFO60796.1 - 2.1e-54 184.6 0.0 2.1e-30 106.0 0.0 2.2 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EFO60796.1 - 2.8e-12 46.8 0.0 1.7e-11 44.3 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EFO60796.1 - 2.5e-06 27.5 0.0 5e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EFO60796.1 - 0.00068 19.3 0.0 0.0016 18.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EFO60796.1 - 0.0042 16.3 2.0 0.021 14.0 0.1 2.3 2 1 1 3 3 3 1 Anion-transporting ATPase MipZ PF09140.11 EFO60796.1 - 0.0086 15.4 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ NACHT PF05729.12 EFO60796.1 - 0.0092 15.9 0.0 0.027 14.4 0.0 1.7 2 0 0 2 2 2 1 NACHT domain AAA_23 PF13476.6 EFO60796.1 - 0.039 14.4 0.0 0.064 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 EFO60796.1 - 0.044 13.7 0.0 0.085 12.7 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase NB-ARC PF00931.22 EFO60796.1 - 0.052 12.7 0.0 0.079 12.1 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain VirC1 PF07015.11 EFO60796.1 - 0.063 12.6 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 VirC1 protein DUF2075 PF09848.9 EFO60796.1 - 0.11 11.7 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 EFO60796.1 - 0.11 12.8 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 EFO60796.1 - 0.12 12.7 0.0 0.4 11.1 0.0 1.8 1 0 0 1 1 1 0 RNA helicase PhoH PF02562.16 EFO60796.1 - 0.18 11.2 0.0 0.33 10.4 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_29 PF13555.6 EFO60796.1 - 0.18 11.6 0.0 0.36 10.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ploopntkinase3 PF18751.1 EFO60796.1 - 0.2 11.6 0.0 16 5.3 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 FeoB_associated PF12669.7 EFO60796.1 - 4.6 7.7 11.1 1 9.8 6.2 2.3 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein Ctf8 PF09696.10 EFO60798.1 - 0.0026 18.1 0.1 0.032 14.5 0.0 2.1 1 1 1 2 2 2 1 Ctf8 IF4E PF01652.18 EFO60799.1 - 2.9e-26 92.1 0.0 3.3e-26 92.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Peptidase_C1 PF00112.23 EFO60800.1 - 1.2e-40 140.0 3.3 1.8e-40 139.3 3.3 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Trypan_PARP PF05887.11 EFO60800.1 - 0.0069 16.4 9.4 0.0069 16.4 9.4 3.1 3 1 0 3 3 3 1 Procyclic acidic repetitive protein (PARP) GPI-anchored PF10342.9 EFO60800.1 - 0.025 15.3 1.2 21 5.9 0.0 3.7 4 0 0 4 4 4 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family TonB_N PF16031.5 EFO60800.1 - 5.6 7.5 16.1 1 9.8 11.3 2.2 2 0 0 2 2 2 0 TonB polyproline region VSP PF03302.13 EFO60801.1 - 2.7e-05 23.2 60.3 0.25 10.2 12.8 3.4 1 1 2 3 3 3 3 Giardia variant-specific surface protein VSP PF03302.13 EFO60802.1 - 5e-34 117.8 99.5 1.9e-21 76.4 35.6 4.4 2 1 2 4 4 4 4 Giardia variant-specific surface protein stn_TNFRSF12A PF12191.8 EFO60802.1 - 0.018 15.2 1.0 0.069 13.4 1.0 2.0 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain IL3Ra_N PF18611.1 EFO60803.1 - 0.16 12.0 0.3 0.32 11.0 0.3 1.4 1 0 0 1 1 1 0 IL-3 receptor alpha chain N-terminal domain DEAD PF00270.29 EFO60804.1 - 6.8e-22 78.1 0.1 1.2e-21 77.2 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO60804.1 - 2.8e-21 75.9 0.0 3.8e-20 72.3 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RPN1_RPN2_N PF17781.1 EFO60804.1 - 0.055 12.9 0.1 2.2 7.6 0.0 2.2 2 0 0 2 2 2 0 RPN1/RPN2 N-terminal domain VSP PF03302.13 EFO60808.1 - 1.1e-25 90.4 108.0 4.1e-14 52.2 48.5 4.6 1 1 3 4 4 4 4 Giardia variant-specific surface protein zf-C2H2_4 PF13894.6 EFO60809.1 - 6.7e-06 26.5 7.7 0.061 14.2 1.0 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFO60809.1 - 0.00026 21.2 3.0 0.0041 17.4 0.7 2.9 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFO60809.1 - 0.0013 19.0 2.2 2.6 8.6 0.9 3.4 3 0 0 3 3 3 1 Zinc-finger of C2H2 type Zn-C2H2_12 PF18112.1 EFO60809.1 - 0.0051 17.2 3.9 0.34 11.4 0.3 3.2 3 0 0 3 3 3 1 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_9 PF16293.5 EFO60809.1 - 0.012 15.4 7.4 4.9 7.1 0.2 3.4 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 EFO60809.1 - 0.025 14.9 5.8 0.55 10.6 1.0 2.8 2 1 1 3 3 2 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 EFO60809.1 - 0.064 13.6 6.1 0.69 10.3 0.3 3.3 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 EFO60809.1 - 0.11 13.0 9.2 8.7 7.0 1.2 3.8 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf_C2H2_6 PF18450.1 EFO60809.1 - 0.13 12.0 2.2 1.8 8.4 0.3 2.5 2 0 0 2 2 2 0 Zinc Finger domain zf-MYST PF17772.1 EFO60809.1 - 0.13 11.9 0.7 8.7 6.0 0.0 2.6 2 0 0 2 2 2 0 MYST family zinc finger domain DUF3039 PF11238.8 EFO60809.1 - 1.1 9.1 5.6 5.5 6.8 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3039) zf-C2H2_6 PF13912.6 EFO60809.1 - 1.7 8.8 6.0 16 5.6 0.1 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger zinc_ribbon_9 PF14369.6 EFO60809.1 - 4 7.8 7.2 16 5.8 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon zf-C2H2_11 PF16622.5 EFO60809.1 - 5 7.0 11.1 0.3 10.9 1.3 2.9 3 0 0 3 3 3 0 zinc-finger C2H2-type GAGA PF09237.11 EFO60809.1 - 5.1 7.0 8.3 1.8 8.4 0.5 3.2 3 0 0 3 3 3 0 GAGA factor TPR_2 PF07719.17 EFO60810.1 - 2.8e-12 45.8 4.8 2.3e-05 24.1 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFO60810.1 - 3.1e-12 45.8 1.9 2.8e-05 23.7 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat STI1 PF17830.1 EFO60810.1 - 8.6e-11 41.6 2.0 8.6e-11 41.6 2.0 1.9 2 0 0 2 2 2 1 STI1 domain TPR_14 PF13428.6 EFO60810.1 - 7.4e-07 29.5 5.7 0.29 12.1 0.0 4.5 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFO60810.1 - 1e-06 29.3 10.2 0.0029 18.2 6.4 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFO60810.1 - 1.1e-06 28.3 3.9 0.0086 16.2 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFO60810.1 - 2.5e-06 27.1 0.0 0.16 12.1 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFO60810.1 - 2.2e-05 24.0 0.4 0.59 9.9 0.1 3.4 2 1 1 3 3 3 3 TPR repeat SGTA_dimer PF16546.5 EFO60810.1 - 0.00011 21.9 0.0 0.00022 20.9 0.0 1.4 1 0 0 1 1 1 1 Homodimerisation domain of SGTA MIT PF04212.18 EFO60810.1 - 0.0062 16.6 0.1 6.2 7.0 0.0 2.8 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain TPR_12 PF13424.6 EFO60810.1 - 0.0074 16.6 1.6 0.25 11.6 0.2 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFO60810.1 - 0.013 16.0 3.2 4 8.0 0.0 3.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFO60810.1 - 0.013 15.6 0.6 0.27 11.4 0.0 2.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFO60810.1 - 0.019 15.3 0.0 0.18 12.3 0.0 2.7 2 0 0 2 2 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFO60810.1 - 0.5 11.1 4.2 6.8 7.6 0.0 3.2 4 0 0 4 4 2 0 Tetratricopeptide repeat RNA_pol_N PF01194.17 EFO60812.1 - 3.2e-29 101.0 0.1 4e-29 100.7 0.1 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Got1 PF04178.12 EFO60814.1 - 8.4e-06 26.2 12.7 1e-05 25.9 12.7 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family rRNA_processing PF08524.11 EFO60815.1 - 1.9e-05 24.7 24.3 0.00013 22.0 24.3 2.0 1 1 0 1 1 1 1 rRNA processing Imm64 PF15600.6 EFO60815.1 - 0.0072 16.0 0.4 0.009 15.7 0.4 1.1 1 0 0 1 1 1 1 Immunity protein 64 RNA_pol_Rpb1_2 PF00623.20 EFO60815.1 - 0.71 10.1 5.1 0.25 11.6 0.7 2.0 1 1 1 2 2 2 0 RNA polymerase Rpb1, domain 2 B56 PF01603.20 EFO60816.1 - 2.4e-98 329.9 21.1 7.7e-87 291.9 9.8 2.8 2 1 0 2 2 2 2 Protein phosphatase 2A regulatory B subunit (B56 family) DUF2063 PF09836.9 EFO60816.1 - 0.13 12.5 0.1 0.8 10.0 0.0 2.3 2 0 0 2 2 2 0 Putative DNA-binding domain Ephrin_rec_like PF07699.13 EFO60818.1 - 0.011 15.5 4.4 0.011 15.5 4.4 14.3 7 5 4 11 11 11 0 Putative ephrin-receptor like VSP PF03302.13 EFO60818.1 - 2.3 7.0 155.7 32 3.2 31.7 6.9 1 1 3 4 4 4 0 Giardia variant-specific surface protein Ank_2 PF12796.7 EFO60819.1 - 1.1e-88 291.9 23.2 5.7e-11 42.9 0.0 11.9 2 2 9 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO60819.1 - 3.8e-43 145.3 23.6 0.00027 21.5 0.0 15.3 9 4 8 17 17 17 16 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60819.1 - 1.2e-41 136.0 26.9 0.067 13.8 0.0 20.5 22 0 0 22 22 22 11 Ankyrin repeat Ank_5 PF13857.6 EFO60819.1 - 5.3e-37 125.4 23.3 0.0072 16.6 0.0 17.2 10 4 8 18 18 18 9 Ankyrin repeats (many copies) Ank PF00023.30 EFO60819.1 - 7.7e-33 111.5 24.1 0.018 15.5 0.0 18.8 21 2 1 22 22 22 8 Ankyrin repeat Ank_2 PF12796.7 EFO60820.1 - 4e-60 200.4 26.2 9.4e-14 51.8 0.1 9.1 2 2 7 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO60820.1 - 4.7e-35 119.5 12.0 1.2e-06 28.9 0.0 11.1 8 3 4 12 12 12 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO60820.1 - 1.5e-29 101.7 23.6 0.00016 21.8 0.1 12.4 5 3 8 13 13 13 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO60820.1 - 7.3e-28 95.8 23.3 0.0016 18.8 0.1 13.7 13 3 2 15 15 15 8 Ankyrin repeat Ank_3 PF13606.6 EFO60820.1 - 5.1e-25 84.8 28.2 0.021 15.4 0.1 15.6 17 0 0 17 17 17 6 Ankyrin repeat DUF4547 PF15080.6 EFO60820.1 - 0.014 15.1 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4547) PRP38 PF03371.15 EFO60821.1 - 4.3e-14 52.8 0.0 6.8e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 PRP38 family EMC3_TMCO1 PF01956.16 EFO60822.1 - 2e-05 24.4 0.1 2.6e-05 24.0 0.1 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like ATG16 PF08614.11 EFO60823.1 - 2.8 8.1 76.0 0.083 13.1 3.5 6.1 4 2 1 5 5 5 0 Autophagy protein 16 (ATG16) Pkinase PF00069.25 EFO60824.1 - 1.4e-49 168.8 0.0 2.1e-48 165.0 0.0 2.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO60824.1 - 6.3e-32 110.9 0.0 7.9e-31 107.3 0.0 2.3 1 1 1 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO60824.1 - 0.012 14.9 0.1 0.15 11.4 0.0 2.6 3 0 0 3 3 3 0 Kinase-like APH PF01636.23 EFO60824.1 - 0.13 12.2 0.0 0.85 9.5 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family YhdX PF17444.2 EFO60824.1 - 0.23 11.3 3.2 0.35 10.8 1.6 2.2 2 1 1 3 3 3 0 Uncharacterized YhdX-like DUF3213 PF11491.8 EFO60824.1 - 1.2 9.3 8.2 6 7.1 0.9 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3213) DUF641 PF04859.12 EFO60824.1 - 2.8 8.3 29.4 11 6.4 0.5 6.7 5 2 2 7 7 7 0 Plant protein of unknown function (DUF641) AAA_12 PF13087.6 EFO60825.1 - 3.3e-14 53.0 0.0 1.2e-13 51.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EFO60825.1 - 4.7e-05 23.3 0.0 0.0002 21.3 0.0 2.0 3 0 0 3 3 3 1 AAA domain UvrD_C_2 PF13538.6 EFO60825.1 - 0.00057 19.7 0.0 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Helicase_C PF00271.31 EFO60826.1 - 2e-17 63.5 0.4 3.7e-13 49.8 0.0 3.1 3 0 0 3 3 3 2 Helicase conserved C-terminal domain DEAD PF00270.29 EFO60826.1 - 4e-17 62.5 0.2 1.2e-16 61.0 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 EFO60826.1 - 6.2e-06 26.9 2.5 1.9e-05 25.3 0.9 2.6 2 0 0 2 2 2 1 RecQ zinc-binding ResIII PF04851.15 EFO60826.1 - 1.1e-05 25.5 0.0 0.00021 21.3 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EFO60826.1 - 0.085 12.6 0.0 0.27 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain UvrD-helicase PF00580.21 EFO60826.1 - 0.089 12.3 0.3 1.6 8.2 0.1 2.6 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain DSPn PF14671.6 EFO60827.1 - 4.3e-46 156.9 0.2 8.3e-46 155.9 0.2 1.5 1 0 0 1 1 1 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 EFO60827.1 - 2.4e-12 46.8 0.0 4.9e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFO60827.1 - 5.8e-05 22.8 0.0 9.2e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EFO60827.1 - 0.00019 21.6 0.0 0.00033 20.8 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EFO60827.1 - 0.059 13.3 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Mif2_N PF15624.6 EFO60827.1 - 7.7 7.2 10.6 27 5.5 10.6 1.9 1 1 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal UQ_con PF00179.26 EFO60828.1 - 1.1e-19 70.5 0.0 1.3e-19 70.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme TTL PF03133.15 EFO60829.1 - 9.6e-47 159.5 0.0 1.5e-46 158.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family Mpp10 PF04006.12 EFO60831.1 - 1.7e-23 83.0 26.9 8.1e-23 80.7 12.0 2.1 1 1 1 2 2 2 2 Mpp10 protein SDA1 PF05285.12 EFO60831.1 - 0.82 9.0 13.7 1 8.7 13.7 1.3 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 EFO60831.1 - 4 6.7 14.7 6 6.1 14.7 1.2 1 0 0 1 1 1 0 BUD22 LRR_4 PF12799.7 EFO60832.1 - 5.4e-09 36.2 11.8 2.1e-05 24.8 4.1 3.7 1 1 4 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO60832.1 - 6.1e-07 29.1 5.1 5.5e-06 26.0 5.3 2.3 2 0 0 2 2 2 1 Leucine rich repeat LRR_9 PF14580.6 EFO60832.1 - 1.2e-06 28.2 2.8 3.9e-06 26.5 1.0 2.2 1 1 1 2 2 2 1 Leucine-rich repeat LRR_6 PF13516.6 EFO60832.1 - 0.00052 19.9 9.4 0.13 12.4 1.1 4.3 4 1 0 4 4 4 2 Leucine Rich repeat LRR_1 PF00560.33 EFO60832.1 - 0.03 14.8 9.7 2.5 9.0 0.9 4.0 3 1 0 3 3 3 0 Leucine Rich Repeat Orthopox_A36R PF05950.11 EFO60832.1 - 0.066 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Orthopoxvirus A36R protein Med2 PF11214.8 EFO60832.1 - 0.067 13.4 1.7 0.074 13.2 0.4 1.8 2 0 0 2 2 2 0 Mediator complex subunit 2 VSP PF03302.13 EFO60833.1 - 4e-66 223.5 138.6 1.5e-45 155.7 26.7 4.1 1 1 3 4 4 4 2 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO60833.1 - 0.012 15.7 0.4 0.035 14.2 0.4 1.7 1 0 0 1 1 1 0 Podoplanin SKG6 PF08693.10 EFO60833.1 - 0.092 12.2 4.1 0.21 11.0 4.1 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain stn_TNFRSF12A PF12191.8 EFO60833.1 - 8.2 6.7 11.2 41 4.4 0.7 4.1 3 0 0 3 3 3 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain VSP PF03302.13 EFO60834.1 - 1.4e-36 126.2 203.3 8.8e-23 80.8 79.9 8.0 1 1 3 4 4 4 4 Giardia variant-specific surface protein RVT_1 PF00078.27 EFO60835.1 - 4.6e-24 85.2 0.0 6e-24 84.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) VSP PF03302.13 EFO60836.1 - 5.3e-28 98.0 121.8 7e-14 51.5 28.6 4.2 1 1 2 3 3 3 3 Giardia variant-specific surface protein Ephrin_rec_like PF07699.13 EFO60836.1 - 0.01 15.6 5.8 0.01 15.6 5.8 11.7 3 2 10 13 13 13 0 Putative ephrin-receptor like Pkinase PF00069.25 EFO60837.1 - 2.6e-59 200.8 0.0 3e-59 200.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO60837.1 - 4.5e-24 85.1 0.0 3.4e-23 82.3 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO60837.1 - 0.0015 17.9 0.0 0.003 16.9 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFO60837.1 - 0.0059 15.6 1.0 0.14 11.1 0.0 2.0 1 1 1 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 EFO60837.1 - 0.0081 15.5 0.3 0.02 14.2 0.4 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFO60837.1 - 0.098 12.2 0.2 0.19 11.3 0.2 1.4 1 1 0 1 1 1 0 RIO1 family APH PF01636.23 EFO60837.1 - 0.15 12.0 0.3 0.49 10.3 0.1 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Ribosomal_L40e PF01020.17 EFO60838.1 - 5e-16 58.3 6.0 8.1e-16 57.7 6.0 1.3 1 0 0 1 1 1 1 Ribosomal L40e family ubiquitin PF00240.23 EFO60838.1 - 1.1e-09 38.0 0.0 1.3e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFO60838.1 - 0.0053 16.6 0.0 0.0087 15.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-RanBP PF00641.18 EFO60838.1 - 0.16 11.4 2.4 0.22 10.9 2.4 1.2 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others zf-ACC PF17848.1 EFO60838.1 - 1.2 9.3 4.5 1.3 9.2 0.5 2.1 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain VSP PF03302.13 EFO60839.1 - 1.8e-110 369.5 105.7 1.4e-54 185.5 51.4 3.1 1 1 2 3 3 3 3 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO60839.1 - 0.0024 18.0 2.3 0.0024 18.0 2.3 6.9 2 1 5 7 7 7 2 Furin-like repeat, cysteine-rich Podoplanin PF05808.11 EFO60839.1 - 0.058 13.5 3.1 0.12 12.5 3.1 1.5 1 1 0 1 1 1 0 Podoplanin RVT_1 PF00078.27 EFO60841.1 - 1.2e-14 54.4 0.0 2e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.6 EFO60841.1 - 1.6e-06 28.5 8.8 0.15 12.9 1.0 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFO60841.1 - 8.4e-06 25.9 2.5 0.014 15.7 0.9 3.2 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFO60841.1 - 9.3e-05 22.7 3.9 0.61 10.6 0.0 3.5 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_9 PF16293.5 EFO60841.1 - 0.001 18.9 5.6 0.054 13.3 0.1 3.4 3 0 0 3 3 3 1 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 EFO60841.1 - 0.0019 18.5 5.4 1.8 8.9 1.3 3.4 2 1 1 3 3 3 1 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EFO60841.1 - 0.0038 17.6 11.7 1.5 9.4 0.0 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 EFO60841.1 - 0.0056 16.4 3.8 0.11 12.3 1.1 2.7 2 0 0 2 2 2 1 zinc-finger C2H2-type Zn-C2H2_12 PF18112.1 EFO60841.1 - 0.029 14.8 4.2 0.93 10.0 0.4 3.1 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain zf-Di19 PF05605.12 EFO60841.1 - 0.052 13.9 8.4 1.7 9.0 0.3 3.5 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_6 PF18450.1 EFO60841.1 - 2.9 7.7 5.0 3.4 7.4 0.2 2.7 3 0 0 3 3 3 0 Zinc Finger domain KptA_kDCL PF18176.1 EFO60842.1 - 0.13 12.1 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 KptA in kinetoplastid DICER domain Flu_PA PF00603.17 EFO60842.1 - 0.18 9.9 0.0 0.24 9.5 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PA Ank_2 PF12796.7 EFO60843.1 - 6.6e-41 138.8 1.8 1.5e-13 51.2 0.1 3.1 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO60843.1 - 2.2e-18 66.3 3.0 2.3e-07 31.2 0.1 3.8 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO60843.1 - 2e-16 59.6 0.2 0.0018 18.6 0.0 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EFO60843.1 - 1.4e-15 57.2 0.7 0.00055 20.2 0.0 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60843.1 - 8.7e-14 50.3 0.1 0.00077 19.7 0.0 5.2 4 1 1 5 5 5 3 Ankyrin repeat DUF2380 PF09533.10 EFO60843.1 - 0.21 11.2 0.0 0.33 10.6 0.0 1.2 1 0 0 1 1 1 0 Predicted lipoprotein of unknown function (DUF2380) Ank_2 PF12796.7 EFO60844.1 - 4.2e-45 152.2 9.7 1.4e-15 57.6 0.2 5.6 3 1 3 6 6 6 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO60844.1 - 7.6e-32 109.3 2.4 3.1e-06 27.6 0.1 8.0 5 1 4 9 9 9 7 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO60844.1 - 1.9e-28 99.6 0.0 7e-28 97.7 0.0 1.9 2 1 0 2 2 2 1 Protein kinase domain Ank_3 PF13606.6 EFO60844.1 - 2.7e-25 85.7 5.9 0.039 14.5 0.1 10.4 11 0 0 11 11 11 6 Ankyrin repeat Ank_5 PF13857.6 EFO60844.1 - 2.4e-23 81.9 13.0 0.00049 20.3 0.0 9.5 3 1 6 10 10 10 7 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO60844.1 - 6e-20 71.6 0.0 1.2e-19 70.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Ank PF00023.30 EFO60844.1 - 4.3e-19 68.0 10.9 0.11 13.0 0.0 9.3 7 2 1 8 8 8 6 Ankyrin repeat APH PF01636.23 EFO60844.1 - 0.021 14.7 0.0 0.058 13.3 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Phage_tail_NK PF16532.5 EFO60844.1 - 0.027 14.1 0.5 0.061 13.0 0.4 1.6 1 1 0 1 1 1 0 Sf6-type phage tail needle knob or tip of some Caudovirales Ank_2 PF12796.7 EFO60845.1 - 2.6e-12 47.2 2.3 3e-06 27.7 0.5 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) zf-C3HC4_3 PF13920.6 EFO60845.1 - 3.5e-10 39.6 12.3 6e-10 38.8 12.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Ank_5 PF13857.6 EFO60845.1 - 1.9e-07 31.2 0.7 0.027 14.8 0.1 3.5 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO60845.1 - 5.4e-07 30.0 0.4 0.0068 17.0 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60845.1 - 3.1e-06 27.1 0.1 0.11 13.1 0.0 3.7 4 0 0 4 4 3 2 Ankyrin repeat Prok-RING_4 PF14447.6 EFO60845.1 - 4.3e-05 23.3 11.6 7.4e-05 22.5 11.6 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Ank PF00023.30 EFO60845.1 - 0.0018 18.7 0.1 0.24 11.9 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat zf-RING_5 PF14634.6 EFO60845.1 - 0.01 15.8 12.5 0.01 15.8 12.5 1.8 2 0 0 2 2 1 0 zinc-RING finger domain TFIIE_alpha PF02002.17 EFO60845.1 - 0.061 13.2 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 TFIIE alpha subunit Peptidase_M60_C PF18630.1 EFO60845.1 - 0.07 13.3 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Peptidase M60 C-terminal domain zf-RING_6 PF14835.6 EFO60845.1 - 0.096 12.6 4.8 0.19 11.6 4.8 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein SEO_C PF14577.6 EFO60845.1 - 0.14 11.5 4.4 0.18 11.3 3.7 1.5 1 1 0 1 1 1 0 Sieve element occlusion C-terminus DUF4815 PF16075.5 EFO60845.1 - 0.17 10.1 0.1 0.21 9.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4815) VWA_N2 PF16164.5 EFO60845.1 - 0.54 10.4 10.0 3.1 8.0 1.8 2.4 1 1 1 2 2 2 0 VWA N-terminal PolC_DP2 PF03833.13 EFO60845.1 - 2.5 5.9 8.2 3.8 5.2 8.2 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 FliT PF05400.13 EFO60845.1 - 2.8 8.8 6.5 1.8 9.5 4.2 1.8 2 0 0 2 2 2 0 Flagellar protein FliT zf-CHY PF05495.12 EFO60845.1 - 5.1 7.6 14.4 36 5.0 4.4 2.3 1 1 1 2 2 2 0 CHY zinc finger ArfGap PF01412.18 EFO60845.1 - 6.6 6.8 13.1 2.6 8.1 4.8 2.8 2 1 1 3 3 3 0 Putative GTPase activating protein for Arf zf-B_box PF00643.24 EFO60845.1 - 7 6.9 14.8 1.5 9.1 9.0 2.2 1 1 1 2 2 2 0 B-box zinc finger zf-C3HC4 PF00097.25 EFO60845.1 - 7.3 6.6 16.1 24 4.9 14.0 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) HK PF02110.15 EFO60846.1 - 0.41 10.0 2.4 0.38 10.1 0.1 1.9 2 0 0 2 2 2 0 Hydroxyethylthiazole kinase family M16C_assoc PF08367.11 EFO60847.1 - 1.4e-18 67.0 0.2 2.2e-18 66.3 0.2 1.3 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EFO60847.1 - 0.00014 22.0 0.1 0.014 15.4 0.0 3.3 3 0 0 3 3 3 1 Peptidase M16 inactive domain Rav1p_C PF12234.8 EFO60848.1 - 3.8e-08 32.2 0.7 6.4e-08 31.5 0.7 1.2 1 0 0 1 1 1 1 RAVE protein 1 C terminal Peptidase_C1 PF00112.23 EFO60849.1 - 7.6e-65 219.1 1.2 8.8e-65 218.8 1.2 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFO60849.1 - 1.6e-06 27.2 0.2 0.00015 20.7 0.2 2.1 2 0 0 2 2 2 2 Peptidase C1-like family VSP PF03302.13 EFO60851.1 - 5.9e-07 28.7 240.8 0.029 13.2 18.9 10.2 1 1 8 9 9 9 6 Giardia variant-specific surface protein Baculo_11_kDa PF06143.11 EFO60851.1 - 0.033 13.8 2.2 0.059 13.0 2.2 1.3 1 0 0 1 1 1 0 Baculovirus 11 kDa family EphA2_TM PF14575.6 EFO60851.1 - 0.058 14.3 0.2 0.16 12.8 0.2 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.20 EFO60851.1 - 0.062 13.2 3.3 0.13 12.2 3.3 1.4 1 0 0 1 1 1 0 Syndecan domain DUF3377 PF11857.8 EFO60851.1 - 0.075 13.0 0.9 0.13 12.2 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Aa_trans PF01490.18 EFO60851.1 - 0.09 11.5 0.1 0.15 10.7 0.1 1.3 1 0 0 1 1 1 0 Transmembrane amino acid transporter protein DUF3827 PF12877.7 EFO60851.1 - 0.098 11.0 0.4 0.14 10.5 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) DUF4577 PF15145.6 EFO60851.1 - 0.17 12.0 0.5 0.34 11.0 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) TMEM154 PF15102.6 EFO60851.1 - 0.35 10.8 1.5 0.62 10.0 1.5 1.3 1 0 0 1 1 1 0 TMEM154 protein family Protocadherin PF08374.11 EFO60851.1 - 9.6 6.1 6.4 6.1 6.8 0.1 2.6 3 0 0 3 3 3 0 Protocadherin RGS PF00615.19 EFO60852.1 - 0.05 13.9 0.9 0.38 11.0 0.0 2.4 1 1 1 2 2 2 0 Regulator of G protein signaling domain VSP PF03302.13 EFO60853.1 - 4e-28 98.4 66.2 1e-16 60.8 8.1 3.8 1 1 2 3 3 3 3 Giardia variant-specific surface protein Pkinase PF00069.25 EFO60855.1 - 4.7e-44 150.7 0.0 6.9e-44 150.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO60855.1 - 1.4e-24 86.8 0.0 2.1e-24 86.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO60855.1 - 8.7e-06 25.2 0.0 1.4e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Ank_2 PF12796.7 EFO60858.1 - 3.8e-109 357.5 41.1 5e-12 46.2 0.3 13.4 4 2 9 13 13 13 13 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO60858.1 - 4e-51 170.8 33.8 2.5e-05 24.7 0.2 18.0 9 7 10 19 19 19 17 Ankyrin repeats (many copies) Ank PF00023.30 EFO60858.1 - 5.4e-49 162.6 36.0 0.012 16.0 0.0 22.3 22 1 0 22 22 22 16 Ankyrin repeat Ank_3 PF13606.6 EFO60858.1 - 3.1e-45 146.9 32.9 0.31 11.7 0.0 22.8 24 0 0 24 24 24 12 Ankyrin repeat Ank_5 PF13857.6 EFO60858.1 - 8.6e-44 147.0 43.4 0.00069 19.9 0.2 19.6 9 4 13 22 22 22 14 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO60858.1 - 4e-07 29.7 0.0 1.6e-06 27.7 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO60858.1 - 0.061 12.6 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Ank_2 PF12796.7 EFO60859.1 - 7.9e-99 324.4 24.7 1.7e-15 57.4 0.1 10.3 2 1 8 11 11 11 10 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO60859.1 - 1.1e-60 200.9 26.1 3.5e-07 30.4 0.2 15.3 4 3 14 18 18 18 17 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO60859.1 - 7.6e-60 198.6 24.8 2.4e-07 31.1 0.0 13.4 8 3 3 13 13 13 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60859.1 - 4e-57 183.4 11.7 0.0095 16.4 0.0 18.8 18 1 1 19 19 19 12 Ankyrin repeat Ank PF00023.30 EFO60859.1 - 3.3e-50 166.4 15.6 0.0016 18.8 0.1 17.4 16 1 1 17 17 17 12 Ankyrin repeat Pkinase PF00069.25 EFO60859.1 - 1.2e-32 113.3 0.0 4.9e-32 111.3 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO60859.1 - 3.7e-19 69.0 0.1 9e-19 67.8 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase NFRKB_winged PF14465.6 EFO60859.1 - 0.0033 17.6 1.9 0.048 13.9 0.6 2.7 2 0 0 2 2 2 1 NFRKB Winged Helix-like APH PF01636.23 EFO60859.1 - 0.08 12.9 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family GBP_C PF02841.14 EFO60859.1 - 0.44 9.9 5.6 0.95 8.8 5.6 1.5 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Spc7 PF08317.11 EFO60862.1 - 0.0027 16.6 3.7 0.0036 16.2 3.7 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein CortBP2 PF09727.9 EFO60862.1 - 0.0048 16.8 7.2 0.0067 16.4 7.2 1.1 1 0 0 1 1 1 1 Cortactin-binding protein-2 AIP3 PF03915.13 EFO60862.1 - 0.006 15.7 0.3 0.0065 15.6 0.3 1.1 1 0 0 1 1 1 1 Actin interacting protein 3 Zwint PF15556.6 EFO60862.1 - 0.013 15.0 0.1 0.018 14.6 0.1 1.2 1 0 0 1 1 1 0 ZW10 interactor CHAD PF05235.14 EFO60862.1 - 0.016 15.2 0.2 0.021 14.8 0.2 1.1 1 0 0 1 1 1 0 CHAD domain RIC1 PF07064.13 EFO60862.1 - 0.017 14.5 0.3 0.022 14.1 0.3 1.1 1 0 0 1 1 1 0 RIC1 MitMem_reg PF13012.6 EFO60862.1 - 0.041 14.3 1.0 0.064 13.7 1.0 1.2 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function CorA PF01544.18 EFO60862.1 - 0.079 12.3 0.9 0.096 12.0 0.9 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein APG6_N PF17675.1 EFO60862.1 - 0.1 13.1 6.0 0.15 12.6 6.0 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region LUC7 PF03194.15 EFO60862.1 - 0.11 12.2 2.7 0.15 11.7 2.7 1.1 1 0 0 1 1 1 0 LUC7 N_terminus zf-C2H2_jaz PF12171.8 EFO60864.1 - 3.3e-06 27.2 0.7 4.5e-06 26.8 0.1 1.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFO60864.1 - 0.0014 18.9 0.1 0.0024 18.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EFO60864.1 - 0.0038 17.5 0.0 0.0043 17.3 0.0 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EFO60864.1 - 0.0059 17.0 0.1 0.011 16.1 0.1 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFO60864.1 - 0.017 15.9 0.1 0.036 14.9 0.1 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger TatD_DNase PF01026.21 EFO60865.1 - 1.1e-23 83.9 0.0 1.7e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase Ank_2 PF12796.7 EFO60867.1 - 2.8e-45 152.8 10.6 1.8e-12 47.7 0.5 6.4 2 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO60867.1 - 1.4e-23 82.6 10.4 0.00085 19.6 0.0 9.0 3 3 7 10 10 10 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO60867.1 - 3.6e-23 81.6 8.1 6.8e-06 26.5 0.0 8.6 8 1 1 9 9 9 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60867.1 - 2.2e-18 64.4 5.7 3.6 8.5 0.0 11.7 12 0 0 12 12 12 3 Ankyrin repeat Ank PF00023.30 EFO60867.1 - 2.5e-15 56.1 4.9 0.34 11.4 0.0 9.6 10 1 1 11 11 11 4 Ankyrin repeat DUF4407 PF14362.6 EFO60867.1 - 0.1 12.0 28.7 0.028 13.8 12.7 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) SUI1 PF01253.22 EFO60867.1 - 0.19 12.3 1.0 13 6.4 0.3 3.1 3 0 0 3 3 3 0 Translation initiation factor SUI1 ERM PF00769.19 EFO60867.1 - 0.43 10.4 42.7 0.1 12.4 7.3 3.9 2 1 1 3 3 3 0 Ezrin/radixin/moesin family PPP1R35_C PF15503.6 EFO60867.1 - 0.43 10.4 7.3 0.053 13.3 1.2 2.5 2 0 0 2 2 2 0 Protein phosphatase 1 regulatory subunit 35 C-terminus NPV_P10 PF05531.12 EFO60867.1 - 0.49 10.9 12.1 2.5 8.6 0.6 4.9 3 3 2 5 5 5 0 Nucleopolyhedrovirus P10 protein Taxilin PF09728.9 EFO60867.1 - 0.57 9.3 35.5 0.15 11.2 20.1 2.6 1 1 0 2 2 2 0 Myosin-like coiled-coil protein Lipoprotein_6 PF01441.19 EFO60867.1 - 0.58 10.1 4.7 5.9 6.9 0.1 3.2 2 1 1 3 3 3 0 Lipoprotein DivIC PF04977.15 EFO60867.1 - 0.79 9.5 23.8 1 9.2 0.1 5.5 4 1 1 5 5 5 0 Septum formation initiator HIP1_clath_bdg PF16515.5 EFO60867.1 - 1.7 9.3 43.9 1.6 9.4 7.0 4.9 2 1 2 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Ank_2 PF12796.7 EFO60868.1 - 6.8e-90 295.8 17.8 1e-15 58.1 0.1 9.1 3 3 6 9 9 9 9 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO60868.1 - 3.8e-59 196.0 24.8 3.4e-05 24.0 0.1 14.5 5 3 9 14 14 14 12 Ankyrin repeats (many copies) Ank PF00023.30 EFO60868.1 - 2.4e-46 154.2 20.3 0.0027 18.1 0.0 16.6 16 2 2 18 18 17 11 Ankyrin repeat Ank_3 PF13606.6 EFO60868.1 - 5.2e-46 149.3 17.2 0.014 15.9 0.0 16.1 17 0 0 17 17 15 11 Ankyrin repeat Ank_4 PF13637.6 EFO60868.1 - 5.5e-45 151.2 17.8 1.6e-07 31.7 0.0 11.7 9 2 4 13 13 13 11 Ankyrin repeats (many copies) APG6_N PF17675.1 EFO60868.1 - 0.00081 19.9 27.9 0.055 14.0 9.6 2.5 1 1 1 2 2 2 2 Apg6 coiled-coil region CENP-H PF05837.12 EFO60868.1 - 0.008 16.6 4.1 0.008 16.6 4.1 2.9 1 1 1 2 2 2 1 Centromere protein H (CENP-H) HALZ PF02183.18 EFO60868.1 - 0.011 15.9 1.4 0.011 15.9 1.4 2.4 2 0 0 2 2 1 0 Homeobox associated leucine zipper KxDL PF10241.9 EFO60868.1 - 0.026 14.8 1.6 0.026 14.8 1.6 3.0 2 1 0 2 2 2 0 Uncharacterized conserved protein PI3K_P85_iSH2 PF16454.5 EFO60868.1 - 0.22 11.1 16.2 0.51 9.9 16.2 1.6 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain FlaC_arch PF05377.11 EFO60868.1 - 0.3 11.5 18.0 1.2 9.6 0.1 4.3 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) FlxA PF14282.6 EFO60868.1 - 0.52 10.3 5.4 1.6 8.7 5.4 1.9 1 1 0 1 1 1 0 FlxA-like protein Fib_alpha PF08702.10 EFO60868.1 - 0.59 10.3 16.8 0.062 13.5 5.2 2.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Fez1 PF06818.15 EFO60868.1 - 1.7 9.0 23.9 0.43 11.0 9.0 2.3 1 1 1 2 2 2 0 Fez1 BRE1 PF08647.11 EFO60868.1 - 2.2 8.4 21.5 7.7 6.7 2.3 3.6 1 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase YabA PF06156.13 EFO60868.1 - 4 8.1 21.5 0.061 14.0 3.2 3.7 1 1 3 4 4 4 0 Initiation control protein YabA Spc7 PF08317.11 EFO60868.1 - 7.9 5.3 27.6 1.5 7.6 4.8 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein Adeno_E3_CR2 PF02439.15 EFO60869.1 - 0.033 13.9 0.9 0.057 13.2 0.9 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DEAD PF00270.29 EFO60870.1 - 7.3e-33 113.8 0.2 1.2e-32 113.1 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO60870.1 - 8.5e-27 93.7 0.0 3.2e-25 88.6 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFO60870.1 - 0.00013 22.0 0.0 0.0003 20.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 EFO60870.1 - 0.00031 20.6 0.0 0.00065 19.6 0.0 1.5 1 0 0 1 1 1 1 Helicase SWI2_SNF2 PF18766.1 EFO60870.1 - 0.059 13.0 0.0 0.088 12.5 0.0 1.3 1 0 0 1 1 1 0 SWI2/SNF2 ATPase RVT_1 PF00078.27 EFO60871.1 - 5.2e-28 98.1 0.0 8e-28 97.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.6 EFO60871.1 - 3.4e-05 24.3 8.2 0.17 12.8 1.0 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFO60871.1 - 0.00031 20.9 1.8 0.016 15.5 0.9 3.1 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFO60871.1 - 0.00096 19.5 3.6 6.1 7.4 0.0 3.4 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_9 PF16293.5 EFO60871.1 - 0.0036 17.1 5.7 0.15 11.9 0.1 3.4 3 0 0 3 3 3 1 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 EFO60871.1 - 0.011 16.1 5.0 2.1 8.7 1.3 3.3 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 EFO60871.1 - 0.079 13.3 8.5 2 8.8 0.3 3.4 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 EFO60871.1 - 0.13 12.8 11.1 11 6.7 1.7 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 EFO60871.1 - 0.19 11.5 3.7 0.12 12.2 1.1 1.9 2 0 0 2 2 2 0 zinc-finger C2H2-type Zn-C2H2_12 PF18112.1 EFO60871.1 - 8 7.0 7.4 1 9.9 0.4 2.8 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain Ank_2 PF12796.7 EFO60872.1 - 2.7e-100 329.1 9.8 3e-15 56.6 0.0 9.0 2 2 6 9 9 9 9 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO60872.1 - 1.1e-61 197.4 11.3 0.0016 18.8 0.0 15.9 16 0 0 16 16 16 13 Ankyrin repeat Ank_5 PF13857.6 EFO60872.1 - 6.1e-59 195.3 22.6 2.6e-05 24.4 0.0 14.3 3 3 11 14 14 14 14 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO60872.1 - 3.7e-57 190.0 8.8 2.8e-08 34.1 0.0 11.2 9 2 2 11 11 11 11 Ankyrin repeats (many copies) Ank PF00023.30 EFO60872.1 - 5e-54 178.5 13.7 0.0031 17.9 0.0 15.9 15 1 1 16 16 16 13 Ankyrin repeat DUF3370 PF11850.8 EFO60872.1 - 0.17 10.7 0.2 22 3.8 0.0 2.9 2 2 0 2 2 2 0 Protein of unknown function (DUF3370) VSP PF03302.13 EFO60873.1 - 2.7e-90 303.1 107.0 4.9e-49 167.2 29.3 7.5 1 1 6 8 8 8 7 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO60873.1 - 0.17 11.9 0.3 0.4 10.8 0.3 1.6 1 0 0 1 1 1 0 Podoplanin VSP PF03302.13 EFO60874.1 - 6.6e-70 236.0 167.9 5e-44 150.8 26.9 4.6 1 1 2 4 4 4 4 Giardia variant-specific surface protein Ank_2 PF12796.7 EFO60875.1 - 6.4e-29 100.4 0.2 5.9e-14 52.4 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO60875.1 - 4.4e-17 62.2 1.9 2e-07 31.4 0.0 3.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO60875.1 - 1.1e-13 51.1 0.4 5.1e-05 23.5 0.0 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60875.1 - 9.4e-12 44.0 0.0 0.00041 20.6 0.0 4.4 4 1 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 EFO60875.1 - 2.5e-11 43.5 0.0 0.0016 18.8 0.0 4.6 5 0 0 5 5 5 2 Ankyrin repeat Zeta_toxin PF06414.12 EFO60875.1 - 0.0071 15.7 0.0 0.0092 15.3 0.0 1.1 1 0 0 1 1 1 1 Zeta toxin RVT_1 PF00078.27 EFO60876.1 - 8.6e-23 81.0 0.0 1.3e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.6 EFO60876.1 - 0.00041 20.9 6.6 0.19 12.7 0.1 3.9 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EFO60876.1 - 3.5 8.3 7.5 5.6 7.6 0.1 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type Ribosomal_L6 PF00347.23 EFO60877.1 - 5.1e-21 75.1 0.2 1.1e-14 54.8 0.0 2.2 2 0 0 2 2 2 2 Ribosomal protein L6 RNase_PH PF01138.21 EFO60878.1 - 9.1e-09 35.9 0.6 1.8e-08 34.9 0.6 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EFO60878.1 - 0.016 15.2 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 PDEase_II PF02112.15 EFO60878.1 - 0.069 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 cAMP phosphodiesterases class-II DUF3450 PF11932.8 EFO60879.1 - 0.11 11.8 24.4 1.4 8.1 0.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) BLOC1_2 PF10046.9 EFO60879.1 - 0.23 11.8 26.2 0.23 11.8 1.2 4.5 4 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ZapB PF06005.12 EFO60879.1 - 0.77 10.2 24.8 0.89 10.0 1.0 4.1 3 1 0 3 3 3 0 Cell division protein ZapB FliD_N PF02465.18 EFO60879.1 - 1.2 9.9 15.4 0.34 11.6 0.3 4.6 1 1 3 4 4 4 0 Flagellar hook-associated protein 2 N-terminus Spc7 PF08317.11 EFO60879.1 - 1.3 7.8 29.1 4.9 5.9 0.6 2.5 2 1 0 2 2 2 0 Spc7 kinetochore protein DUF4407 PF14362.6 EFO60879.1 - 2.1 7.6 15.9 7.1 5.9 11.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) CpxA_peri PF16527.5 EFO60879.1 - 2.3 8.6 6.9 19 5.6 0.0 3.3 2 1 1 3 3 3 0 Two-component sensor protein CpxA, periplasmic domain Laminin_II PF06009.12 EFO60879.1 - 2.8 8.0 21.9 0.43 10.6 1.5 3.3 2 1 1 3 3 3 0 Laminin Domain II YabA PF06156.13 EFO60879.1 - 3.8 8.2 23.1 3.5 8.3 10.5 3.8 2 2 0 3 3 3 0 Initiation control protein YabA HIP1_clath_bdg PF16515.5 EFO60879.1 - 5.5 7.7 28.4 2.1 9.0 3.7 3.6 2 2 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 SOGA PF11365.8 EFO60879.1 - 6.2 8.0 19.2 3 9.0 6.9 2.8 2 1 0 3 3 3 0 Protein SOGA DUF948 PF06103.11 EFO60879.1 - 6.4 7.1 11.0 10 6.5 0.0 3.5 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) ADIP PF11559.8 EFO60880.1 - 2.9e-05 24.2 14.9 2.9e-05 24.2 14.9 6.4 1 1 6 7 7 7 2 Afadin- and alpha -actinin-Binding NYD-SP28 PF14772.6 EFO60880.1 - 0.016 15.3 4.7 0.016 15.3 4.7 9.2 2 1 8 10 10 10 0 Sperm tail Prefoldin_2 PF01920.20 EFO60880.1 - 0.016 15.2 2.1 0.016 15.2 2.1 7.5 4 3 1 6 6 6 0 Prefoldin subunit Peptidase_C15 PF01470.17 EFO60880.1 - 0.13 12.4 0.2 0.13 12.4 0.2 2.0 2 0 0 2 2 2 0 Pyroglutamyl peptidase DUF3626 PF12294.8 EFO60880.1 - 0.33 9.9 7.4 0.029 13.4 1.8 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3626) Golgin_A5 PF09787.9 EFO60880.1 - 0.42 10.0 93.0 2 7.8 13.3 5.1 1 1 4 5 5 5 0 Golgin subfamily A member 5 Spc7 PF08317.11 EFO60880.1 - 0.8 8.5 96.6 0.0054 15.6 24.5 4.7 1 1 4 5 5 5 0 Spc7 kinetochore protein AIP3 PF03915.13 EFO60880.1 - 5.1 6.1 70.2 1.4 7.9 19.1 4.3 1 1 3 4 4 4 0 Actin interacting protein 3 DUF4407 PF14362.6 EFO60880.1 - 9.8 5.4 73.5 0.29 10.4 9.0 4.2 1 1 3 4 4 4 0 Domain of unknown function (DUF4407) VSP PF03302.13 EFO60881.1 - 6.3e-73 245.9 90.2 6.3e-73 245.9 90.2 2.1 1 1 1 2 2 2 1 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO60881.1 - 0.00016 21.8 17.6 0.00016 21.8 17.6 7.6 1 1 6 7 7 7 2 Furin-like repeat, cysteine-rich PsbX PF06596.11 EFO60881.1 - 6.8 6.8 7.1 11 6.1 7.1 1.3 1 0 0 1 1 1 0 Photosystem II reaction centre X protein (PsbX) Ciart PF15673.5 EFO60882.1 - 0.2 11.0 0.1 0.32 10.3 0.1 1.2 1 0 0 1 1 1 0 Circadian-associated transcriptional repressor DUF2070 PF09843.9 EFO60882.1 - 0.36 9.1 4.9 0.5 8.6 4.9 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) MFS_1 PF07690.16 EFO60883.1 - 7.5e-33 113.9 46.8 1.1e-28 100.2 31.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFO60883.1 - 2e-05 23.3 25.9 0.00062 18.4 4.1 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein Lac_bphage_repr PF06543.12 EFO60883.1 - 0.11 12.5 0.1 0.26 11.3 0.1 1.6 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor VSP PF03302.13 EFO60884.1 - 3.8e-43 147.8 97.2 1e-30 106.9 61.9 3.6 1 1 2 3 3 3 3 Giardia variant-specific surface protein cEGF PF12662.7 EFO60884.1 - 0.002 18.0 1.5 0.002 18.0 1.5 7.1 9 0 0 9 9 9 2 Complement Clr-like EGF-like RVT_1 PF00078.27 EFO60885.1 - 0.092 12.2 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) EGF_2 PF07974.13 EFO60886.1 - 0.0002 21.6 17.8 0.00046 20.5 5.1 20.7 19 1 1 20 20 20 13 EGF-like domain VSP PF03302.13 EFO60887.1 - 3.8e-23 82.0 18.4 4.7e-23 81.7 18.4 1.1 1 0 0 1 1 1 1 Giardia variant-specific surface protein FhuF_C PF11575.8 EFO60887.1 - 0.3 11.0 0.2 0.3 11.0 0.2 3.5 3 0 0 3 3 3 0 FhuF 2Fe-2S C-terminal domain Pkinase PF00069.25 EFO60889.1 - 3e-32 112.0 0.0 1.1e-31 110.2 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO60889.1 - 2.3e-18 66.4 0.0 1.5e-17 63.8 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO60889.1 - 0.0018 17.6 0.0 0.0029 16.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like JIP_LZII PF16471.5 EFO60889.1 - 0.0068 16.6 0.7 0.0068 16.6 0.7 2.7 3 0 0 3 3 3 1 JNK-interacting protein leucine zipper II ZapB PF06005.12 EFO60889.1 - 0.028 14.9 6.8 0.046 14.2 3.1 2.5 2 0 0 2 2 2 0 Cell division protein ZapB DUF848 PF05852.11 EFO60889.1 - 0.039 14.1 3.0 0.36 10.9 0.5 2.4 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) HALZ PF02183.18 EFO60889.1 - 0.054 13.7 0.2 0.054 13.7 0.2 2.7 3 0 0 3 3 3 0 Homeobox associated leucine zipper BLOC1_2 PF10046.9 EFO60889.1 - 0.067 13.5 3.7 0.32 11.3 0.5 2.9 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NAD_synthase PF02540.17 EFO60889.1 - 0.13 11.3 0.2 0.2 10.7 0.2 1.3 1 0 0 1 1 1 0 NAD synthase DivIC PF04977.15 EFO60889.1 - 0.23 11.2 6.4 0.07 12.9 2.7 2.1 2 0 0 2 2 2 0 Septum formation initiator APG6_N PF17675.1 EFO60889.1 - 0.43 11.1 6.5 0.1 13.1 3.0 1.8 2 0 0 2 2 2 0 Apg6 coiled-coil region Aminotran_1_2 PF00155.21 EFO60891.1 - 4.1e-34 118.3 0.0 5.2e-34 118.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EFO60891.1 - 0.00039 19.8 0.0 0.00072 18.9 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase HTH_23 PF13384.6 EFO60891.1 - 0.14 12.0 0.0 1.6 8.7 0.0 2.6 2 0 0 2 2 2 0 Homeodomain-like domain TPR_8 PF13181.6 EFO60892.1 - 0.00046 20.2 0.9 0.049 13.9 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFO60892.1 - 0.0048 16.8 0.9 3.2 8.0 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat Imm15 PF15561.6 EFO60892.1 - 0.026 14.8 0.7 1.5 9.1 0.4 2.9 3 0 0 3 3 3 0 Immunity protein 15 TPR_2 PF07719.17 EFO60892.1 - 0.046 13.8 1.0 0.44 10.8 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFO60892.1 - 0.094 13.6 4.2 0.73 10.8 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat AATF-Che1 PF13339.6 EFO60892.1 - 0.097 13.4 0.4 0.22 12.2 0.0 1.8 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor ANAPC3 PF12895.7 EFO60892.1 - 0.14 12.4 4.2 0.058 13.6 1.1 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EFO60892.1 - 0.19 12.3 2.4 3.5 8.2 0.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat RVT_1 PF00078.27 EFO60893.1 - 4.6e-24 85.2 0.0 6e-24 84.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EGF_2 PF07974.13 EFO60894.1 - 0.00048 20.4 5.7 0.00048 20.4 5.7 24.3 22 1 0 22 22 22 15 EGF-like domain EGF PF00008.27 EFO60894.1 - 0.0072 16.6 3.9 0.0072 16.6 3.9 23.6 23 1 0 23 23 23 12 EGF-like domain HGTP_anticodon PF03129.20 EFO60895.1 - 1.3e-21 76.5 0.0 2.5e-21 75.6 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EFO60895.1 - 8.4e-12 45.4 0.0 2.6e-11 43.8 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Oxysterol_BP PF01237.18 EFO60896.1 - 4.4e-24 85.0 0.6 1.6e-13 50.3 0.0 3.1 1 1 1 3 3 3 3 Oxysterol-binding protein Ank_2 PF12796.7 EFO60897.1 - 3.1e-75 248.8 21.4 1.3e-12 48.1 0.1 7.6 4 3 4 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO60897.1 - 6.6e-43 144.6 14.5 1.4e-07 31.9 0.0 12.7 10 3 3 13 13 13 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60897.1 - 1.7e-40 132.3 11.7 0.0054 17.1 0.0 14.0 14 0 0 14 14 14 9 Ankyrin repeat Ank_5 PF13857.6 EFO60897.1 - 1e-38 130.9 15.4 5.5e-06 26.6 0.1 12.4 7 5 6 13 13 13 9 Ankyrin repeats (many copies) Ank PF00023.30 EFO60897.1 - 7e-36 121.1 8.3 0.00061 20.1 0.0 13.3 12 1 1 13 13 13 7 Ankyrin repeat DUF503 PF04456.12 EFO60897.1 - 0.37 10.7 2.8 11 6.0 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF503) Aldo_ket_red PF00248.21 EFO60898.1 - 1.9e-36 125.8 0.0 4e-36 124.7 0.0 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family HEAT PF02985.22 EFO60899.1 - 0.004 17.3 0.2 0.47 10.8 0.1 3.3 2 0 0 2 2 2 1 HEAT repeat Cohesin_HEAT PF12765.7 EFO60899.1 - 0.09 13.1 0.6 9.3 6.7 0.2 2.8 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion DHODB_Fe-S_bind PF10418.9 EFO60901.1 - 0.021 14.6 5.6 0.021 14.6 5.6 3.5 4 1 0 4 4 4 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B VSP PF03302.13 EFO60901.1 - 5 5.9 45.4 0.73 8.6 13.4 3.1 1 1 2 3 3 3 0 Giardia variant-specific surface protein VSP PF03302.13 EFO60902.1 - 1.6e-115 386.2 94.8 1.6e-115 386.2 94.8 2.3 1 1 0 2 2 2 1 Giardia variant-specific surface protein KORA PF16509.5 EFO60903.1 - 0.016 15.5 0.0 0.058 13.7 0.0 1.9 1 0 0 1 1 1 0 TrfB plasmid transcriptional repressor Macoilin PF09726.9 EFO60903.1 - 2.6 6.5 42.9 0.15 10.6 32.8 2.4 2 1 0 2 2 2 0 Macoilin family ANAPC4_WD40 PF12894.7 EFO60904.1 - 8.7e-11 42.0 0.0 0.0028 17.9 0.0 4.9 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFO60904.1 - 1.4e-10 41.6 8.9 0.046 14.6 0.0 6.5 7 0 0 7 7 7 4 WD domain, G-beta repeat FKBP_C PF00254.28 EFO60905.1 - 2.4e-26 91.9 0.1 7.7e-26 90.2 0.0 1.8 2 1 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase IMD PF08397.11 EFO60906.1 - 0.078 12.4 0.0 0.19 11.1 0.0 1.6 1 0 0 1 1 1 0 IRSp53/MIM homology domain Ank_5 PF13857.6 EFO60907.1 - 1.5e-07 31.5 0.4 0.00011 22.4 0.1 3.6 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO60907.1 - 0.00034 21.1 2.2 11 6.7 0.0 3.9 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFO60907.1 - 0.0009 19.8 1.0 0.087 13.4 0.1 3.8 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFO60907.1 - 0.036 14.5 1.4 10 6.7 0.1 3.3 2 0 0 2 2 2 0 Ankyrin repeat Ank_3 PF13606.6 EFO60907.1 - 0.12 13.0 2.0 15 6.6 0.0 3.8 3 0 0 3 3 3 0 Ankyrin repeat SpoU_methylase PF00588.19 EFO60908.1 - 1.7e-05 25.0 0.0 3.4e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 SpoU rRNA Methylase family DUF2318 PF10080.9 EFO60908.1 - 0.071 13.2 0.2 0.16 12.1 0.2 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) Rho_GDI PF02115.17 EFO60909.1 - 1.4e-23 83.7 0.0 1.6e-23 83.5 0.0 1.2 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Aa_trans PF01490.18 EFO60911.1 - 9.1e-55 186.0 38.1 1.1e-54 185.7 38.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2484 PF10658.9 EFO60911.1 - 0.17 12.2 3.5 0.66 10.3 0.7 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2484) Ank_2 PF12796.7 EFO60912.1 - 7.7e-15 55.3 0.1 3.1e-08 34.1 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO60912.1 - 3.6e-11 43.1 1.2 0.0012 19.1 0.1 4.4 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60912.1 - 9.1e-10 37.9 0.4 0.047 14.3 0.0 4.9 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EFO60912.1 - 2e-08 34.3 0.9 0.06 13.8 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EFO60912.1 - 7.8e-06 26.3 0.5 0.089 13.4 0.3 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) ZapB PF06005.12 EFO60912.1 - 3.8 8.0 10.2 11 6.6 0.2 4.4 4 1 1 5 5 5 0 Cell division protein ZapB Ank_2 PF12796.7 EFO60913.1 - 1.6e-19 70.3 3.1 7.7e-11 42.4 0.2 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO60913.1 - 6.9e-10 38.3 2.3 0.47 11.2 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EFO60913.1 - 2.6e-09 37.1 2.4 0.04 14.4 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EFO60913.1 - 6.4e-09 35.9 3.7 0.027 14.8 0.1 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO60913.1 - 1.5e-08 35.0 2.3 0.0038 17.8 0.2 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) SlyX PF04102.12 EFO60913.1 - 0.0017 19.0 1.8 0.0017 19.0 1.8 7.4 8 0 0 8 8 7 1 SlyX Spc7 PF08317.11 EFO60913.1 - 0.0042 16.0 8.8 0.0042 16.0 8.8 5.3 5 2 2 7 7 7 2 Spc7 kinetochore protein TolA_bind_tri PF16331.5 EFO60913.1 - 0.018 15.1 0.6 0.018 15.1 0.6 7.5 8 1 0 8 8 8 0 TolA binding protein trimerisation NRBF2 PF08961.10 EFO60913.1 - 0.043 13.4 0.1 0.043 13.4 0.1 5.4 5 3 2 8 8 8 0 Nuclear receptor-binding factor 2, autophagy regulator YabA PF06156.13 EFO60913.1 - 0.052 14.2 35.8 2.1 9.0 0.0 8.7 5 3 3 9 9 9 0 Initiation control protein YabA VGPC1_C PF16799.5 EFO60913.1 - 0.16 12.0 3.7 0.24 11.4 0.6 2.9 3 0 0 3 3 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 Atg14 PF10186.9 EFO60913.1 - 0.21 10.6 31.3 0.013 14.6 5.3 4.4 3 1 1 4 4 4 0 Vacuolar sorting 38 and autophagy-related subunit 14 HALZ PF02183.18 EFO60913.1 - 0.47 10.7 23.6 2.7 8.3 0.4 7.3 7 0 0 7 7 7 0 Homeobox associated leucine zipper APC_N_CC PF16689.5 EFO60913.1 - 0.55 10.3 10.4 0.64 10.1 0.1 4.7 4 0 0 4 4 4 0 Coiled-coil N-terminus of APC, dimerisation domain Dna2 PF08696.11 EFO60915.1 - 1.8e-05 24.7 0.1 0.00012 21.9 0.1 2.6 1 1 0 1 1 1 1 DNA replication factor Dna2 Ank_2 PF12796.7 EFO60916.1 - 4.5e-47 158.5 13.9 1.4e-11 44.8 0.5 5.8 2 2 4 6 6 6 5 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO60916.1 - 1.7e-27 96.4 0.0 5.6e-27 94.8 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain Ank PF00023.30 EFO60916.1 - 3.1e-25 87.5 4.3 0.021 15.3 0.0 9.5 8 2 1 9 9 9 7 Ankyrin repeat Ank_3 PF13606.6 EFO60916.1 - 3.1e-23 79.3 6.4 0.18 12.5 0.0 10.2 9 1 1 10 10 10 7 Ankyrin repeat Ank_5 PF13857.6 EFO60916.1 - 1.5e-22 79.4 13.1 0.00016 21.9 0.2 8.2 3 2 6 9 9 9 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO60916.1 - 6.2e-22 77.7 5.3 0.0014 19.2 0.0 8.7 6 3 3 9 9 9 7 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO60916.1 - 4.3e-15 55.7 0.0 1.1e-14 54.4 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase 2-Hacid_dh_C PF02826.19 EFO60917.1 - 0.045 13.1 0.0 0.063 12.6 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TTL PF03133.15 EFO60918.1 - 9.1e-68 228.5 0.0 1.3e-67 228.0 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EFO60918.1 - 1.3e-07 31.1 0.0 3.3e-05 23.3 0.0 2.5 2 1 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EFO60918.1 - 3.6e-05 23.2 0.0 0.0023 17.2 0.0 2.2 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp Topoisom_bac PF01131.20 EFO60919.1 - 1.5e-95 320.6 0.0 2.1e-95 320.2 0.0 1.2 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 EFO60919.1 - 6.8e-14 52.0 0.0 2e-13 50.5 0.0 1.8 2 0 0 2 2 2 1 Toprim domain Toprim_2 PF13155.6 EFO60919.1 - 0.0012 19.2 0.0 0.0035 17.7 0.0 1.8 1 0 0 1 1 1 1 Toprim-like Toprim_4 PF13662.6 EFO60919.1 - 0.024 15.1 0.0 0.1 13.1 0.0 2.1 2 0 0 2 2 2 0 Toprim domain RVT_1 PF00078.27 EFO60920.1 - 5e-28 98.1 0.0 6.6e-28 97.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FOP_dimer PF09398.10 EFO60921.1 - 3.3e-08 33.7 0.0 5.4e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 FOP N terminal dimerisation domain VSP PF03302.13 EFO60922.1 - 2.1e-40 138.8 178.9 1.5e-30 106.4 68.1 7.6 1 1 4 5 5 5 4 Giardia variant-specific surface protein RVT_1 PF00078.27 EFO60923.1 - 0.0074 15.8 0.0 0.01 15.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Tir_receptor_N PF07490.11 EFO60924.1 - 0.054 13.3 0.1 0.07 12.9 0.1 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) N-terminus DUF2173 PF09941.9 EFO60925.1 - 0.14 12.5 0.0 0.35 11.2 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2173) VSP PF03302.13 EFO60926.1 - 8.9e-18 64.3 193.1 0.00027 19.9 32.9 7.4 1 1 6 7 7 7 7 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO60926.1 - 0.0043 17.2 9.0 0.0043 17.2 9.0 11.6 1 1 10 12 12 12 7 Furin-like repeat, cysteine-rich RVT_1 PF00078.27 EFO60927.1 - 3.6e-22 79.0 0.0 4.8e-22 78.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.6 EFO60927.1 - 0.00041 21.0 5.8 0.41 11.6 0.4 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EFO60927.1 - 0.03 14.3 3.8 0.089 12.8 0.9 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_12 PF18658.1 EFO60927.1 - 0.044 13.4 0.5 0.17 11.5 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger C2H2-type zf-C2H2 PF00096.26 EFO60927.1 - 0.045 14.2 3.4 1.8 9.2 1.6 3.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EFO60927.1 - 0.12 12.6 0.0 0.72 10.2 0.0 2.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 EFO60927.1 - 0.18 11.5 0.0 0.38 10.4 0.0 1.5 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain Ank_2 PF12796.7 EFO60928.1 - 2.2e-57 191.6 0.6 2.6e-15 56.7 0.1 4.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EFO60928.1 - 1.7e-42 142.0 0.9 8e-05 22.9 0.0 7.9 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 EFO60928.1 - 3e-38 129.4 8.6 6e-06 26.4 0.0 7.6 2 1 6 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60928.1 - 6.7e-36 118.2 0.1 0.00029 21.0 0.0 7.4 7 0 0 7 7 7 7 Ankyrin repeat Ank_4 PF13637.6 EFO60928.1 - 2.3e-35 120.5 2.6 2.1e-08 34.5 0.0 5.9 5 1 0 5 5 5 4 Ankyrin repeats (many copies) 3HCDH_RFF PF18321.1 EFO60928.1 - 0.014 15.8 0.7 2e+02 2.5 0.0 5.2 6 0 0 6 6 6 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain ERAP1_C PF11838.8 EFO60928.1 - 0.057 13.0 0.7 14 5.1 0.0 3.6 1 1 3 5 5 5 0 ERAP1-like C-terminal domain VSP PF03302.13 EFO60929.1 - 7.2e-83 278.6 189.4 8.8e-43 146.6 26.5 6.3 1 1 6 7 7 7 6 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO60929.1 - 0.011 15.9 0.1 0.038 14.1 0.1 1.9 1 0 0 1 1 1 0 Podoplanin Ank_2 PF12796.7 EFO60930.1 - 1.2e-147 480.8 58.0 1.5e-18 67.1 0.5 12.4 2 1 16 18 18 17 17 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO60930.1 - 3.7e-74 244.2 25.0 1.1e-09 38.6 0.1 15.6 11 5 3 14 14 14 13 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO60930.1 - 1.3e-65 216.5 33.7 9.3e-06 25.8 0.1 20.2 4 4 15 20 20 20 18 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60930.1 - 4.5e-65 207.9 23.1 0.002 18.4 0.0 23.1 21 2 2 23 23 23 14 Ankyrin repeat Ank PF00023.30 EFO60930.1 - 3.3e-63 207.6 37.6 8.8e-05 22.8 0.0 22.5 23 0 0 23 23 22 16 Ankyrin repeat Pkinase PF00069.25 EFO60930.1 - 1.9e-33 116.0 0.0 5.4e-33 114.5 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO60930.1 - 1e-21 77.4 0.0 1.7e-21 76.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase TolA_bind_tri PF16331.5 EFO60930.1 - 0.0001 22.3 0.2 0.00019 21.4 0.2 1.5 1 0 0 1 1 1 1 TolA binding protein trimerisation APH PF01636.23 EFO60930.1 - 0.00042 20.3 0.2 0.0025 17.8 0.2 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family HrpB7 PF09486.10 EFO60930.1 - 0.0015 19.0 1.8 0.005 17.2 1.8 1.9 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB7) Spc7 PF08317.11 EFO60930.1 - 0.0023 16.8 0.3 0.0038 16.2 0.3 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein BRE1 PF08647.11 EFO60930.1 - 0.0091 16.0 2.2 0.0091 16.0 0.2 2.0 2 0 0 2 2 2 1 BRE1 E3 ubiquitin ligase Fez1 PF06818.15 EFO60930.1 - 0.027 14.9 0.4 0.05 14.0 0.4 1.3 1 0 0 1 1 1 0 Fez1 XhlA PF10779.9 EFO60930.1 - 0.035 14.3 0.9 0.46 10.7 0.6 2.3 1 1 0 2 2 2 0 Haemolysin XhlA CEP63 PF17045.5 EFO60930.1 - 0.06 13.2 0.2 0.11 12.4 0.2 1.3 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa Kinase-like PF14531.6 EFO60930.1 - 0.066 12.5 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Kinase-like CENP-F_leu_zip PF10473.9 EFO60930.1 - 0.096 12.7 0.5 0.21 11.6 0.5 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Striatin PF08232.12 EFO60930.1 - 0.14 12.7 0.3 0.28 11.8 0.3 1.5 1 0 0 1 1 1 0 Striatin family DivIC PF04977.15 EFO60930.1 - 0.66 9.8 2.2 1.4 8.8 2.2 1.5 1 0 0 1 1 1 0 Septum formation initiator Ank_2 PF12796.7 EFO60931.1 - 2.7e-37 127.2 11.3 2.4e-12 47.3 0.1 3.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO60931.1 - 7e-17 61.3 4.8 0.077 13.3 0.0 5.6 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO60931.1 - 2.2e-16 59.5 1.5 0.29 11.7 0.0 6.1 5 1 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.6 EFO60931.1 - 8.5e-16 56.5 2.0 0.036 14.6 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 EFO60931.1 - 1.8e-10 41.1 1.9 0.0018 18.8 0.0 5.1 3 1 2 5 5 4 3 Ankyrin repeats (many copies) ATG16 PF08614.11 EFO60931.1 - 0.0011 19.3 13.7 0.039 14.2 4.1 2.3 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) ERM PF00769.19 EFO60931.1 - 0.0027 17.5 9.1 0.018 14.8 6.4 2.4 1 1 1 2 2 2 1 Ezrin/radixin/moesin family DUF1192 PF06698.11 EFO60931.1 - 0.0067 16.5 1.7 0.75 9.9 0.2 3.6 3 0 0 3 3 3 1 Protein of unknown function (DUF1192) DUF724 PF05266.14 EFO60931.1 - 0.0067 16.3 11.2 0.65 9.8 0.3 2.6 1 1 2 3 3 3 2 Protein of unknown function (DUF724) MscS_porin PF12795.7 EFO60931.1 - 0.0069 16.0 6.3 0.0069 16.0 6.3 2.4 2 1 0 2 2 2 1 Mechanosensitive ion channel porin domain FlaC_arch PF05377.11 EFO60931.1 - 0.0072 16.7 6.6 1.7 9.1 3.8 3.4 3 0 0 3 3 3 1 Flagella accessory protein C (FlaC) TMF_TATA_bd PF12325.8 EFO60931.1 - 0.012 15.8 11.2 0.38 11.0 6.3 2.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding APG6_N PF17675.1 EFO60931.1 - 0.013 16.0 9.8 0.97 10.0 3.5 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region Fez1 PF06818.15 EFO60931.1 - 0.027 15.0 7.7 0.049 14.1 6.2 2.1 1 1 0 1 1 1 0 Fez1 ADIP PF11559.8 EFO60931.1 - 0.034 14.3 16.6 0.1 12.7 5.7 3.1 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding WXG100 PF06013.12 EFO60931.1 - 0.034 14.4 6.1 0.5 10.6 0.0 3.2 2 1 1 3 3 2 0 Proteins of 100 residues with WXG HIP1_clath_bdg PF16515.5 EFO60931.1 - 0.041 14.5 11.0 0.17 12.5 5.1 2.7 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF641 PF04859.12 EFO60931.1 - 0.056 13.8 9.4 1.4 9.2 4.4 2.6 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Filament PF00038.21 EFO60931.1 - 0.071 12.7 12.5 0.18 11.4 3.3 1.9 1 1 0 1 1 1 0 Intermediate filament protein T4SS_TraI PF16932.5 EFO60931.1 - 0.096 11.8 0.4 0.59 9.3 0.0 2.2 2 0 0 2 2 2 0 Type IV secretory system, conjugal DNA-protein transfer Csm1_N PF18504.1 EFO60931.1 - 0.12 12.8 12.7 2.8 8.3 4.1 3.8 3 2 2 5 5 4 0 Csm1 N-terminal domain ABC_tran_CTD PF16326.5 EFO60931.1 - 0.17 12.2 10.7 4.3 7.7 5.5 3.4 2 1 2 4 4 4 0 ABC transporter C-terminal domain DivIC PF04977.15 EFO60931.1 - 0.17 11.7 19.3 0.3 10.9 4.7 4.2 2 2 2 4 4 4 0 Septum formation initiator DHR10 PF18595.1 EFO60931.1 - 0.18 11.9 19.2 0.14 12.2 6.6 2.9 3 0 0 3 3 2 0 Designed helical repeat protein 10 domain CCDC144C PF14915.6 EFO60931.1 - 0.18 10.9 13.9 0.21 10.7 10.4 2.3 1 1 1 2 2 2 0 CCDC144C protein coiled-coil region Paralemmin PF03285.15 EFO60931.1 - 0.25 10.9 4.9 0.36 10.4 4.5 1.4 1 1 0 1 1 1 0 Paralemmin TolA_bind_tri PF16331.5 EFO60931.1 - 0.26 11.4 17.1 0.033 14.3 7.3 3.2 2 1 0 2 2 2 0 TolA binding protein trimerisation DUF3450 PF11932.8 EFO60931.1 - 0.28 10.5 16.0 0.49 9.7 8.0 2.6 2 1 0 3 3 2 0 Protein of unknown function (DUF3450) CALCOCO1 PF07888.11 EFO60931.1 - 0.32 9.8 11.8 1.2 7.9 11.8 1.8 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like GAS PF13851.6 EFO60931.1 - 0.51 9.6 13.3 5.7 6.2 13.3 2.2 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding SlyX PF04102.12 EFO60931.1 - 0.63 10.7 17.3 2.9 8.6 8.6 3.7 2 2 1 3 3 3 0 SlyX DUF4164 PF13747.6 EFO60931.1 - 0.74 10.1 16.0 0.23 11.8 5.3 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) Fib_alpha PF08702.10 EFO60931.1 - 0.9 9.7 14.9 0.52 10.5 0.5 2.6 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Rootletin PF15035.6 EFO60931.1 - 0.97 9.4 8.1 1.3 9.0 7.0 1.7 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF4407 PF14362.6 EFO60931.1 - 0.97 8.7 10.0 1.7 7.9 10.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MbeD_MobD PF04899.12 EFO60931.1 - 1.1 9.4 6.5 15 5.8 1.5 2.9 3 1 0 3 3 2 0 MbeD/MobD like Spc7 PF08317.11 EFO60931.1 - 1.1 8.0 13.5 3.1 6.6 13.3 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein BRE1 PF08647.11 EFO60931.1 - 1.3 9.2 13.8 21 5.3 7.2 4.0 2 1 2 4 4 4 0 BRE1 E3 ubiquitin ligase LPP PF04728.13 EFO60931.1 - 1.3 9.5 12.9 8.2 6.9 0.2 4.3 3 1 1 4 4 4 0 Lipoprotein leucine-zipper Occludin_ELL PF07303.13 EFO60931.1 - 1.5 9.6 4.7 1.2 9.9 1.4 2.5 2 1 1 3 3 2 0 Occludin homology domain TMF_DNA_bd PF12329.8 EFO60931.1 - 1.6 8.8 15.4 4.6 7.3 0.4 3.8 1 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding YabA PF06156.13 EFO60931.1 - 1.7 9.4 10.4 2 9.1 4.7 2.7 1 1 2 3 3 3 0 Initiation control protein YabA NRBF2 PF08961.10 EFO60931.1 - 1.7 8.2 6.8 0.78 9.3 2.9 2.1 1 1 1 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator PI3K_P85_iSH2 PF16454.5 EFO60931.1 - 2.4 7.7 11.0 7.7 6.1 0.8 2.2 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Tropomyosin_1 PF12718.7 EFO60931.1 - 3 8.0 13.7 9.1 6.4 5.8 2.5 1 1 0 2 2 2 0 Tropomyosin like DUF1664 PF07889.12 EFO60931.1 - 3.5 7.7 10.8 7.6 6.6 5.1 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) FlxA PF14282.6 EFO60931.1 - 3.9 7.5 20.4 0.76 9.8 13.4 2.8 1 1 2 3 3 3 0 FlxA-like protein Jnk-SapK_ap_N PF09744.9 EFO60931.1 - 3.9 7.7 9.6 1.5 9.1 4.2 2.5 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 Swi5 PF07061.11 EFO60931.1 - 4.1 7.6 10.2 4.3 7.5 4.1 3.5 1 1 2 3 3 3 0 Swi5 UPF0242 PF06785.11 EFO60931.1 - 4.3 7.4 15.3 3.3 7.8 7.5 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus BST2 PF16716.5 EFO60931.1 - 4.9 7.8 10.9 6.8 7.4 2.1 3.3 1 1 1 3 3 3 0 Bone marrow stromal antigen 2 TPR_MLP1_2 PF07926.12 EFO60931.1 - 5.7 7.0 13.3 51 3.9 0.5 3.3 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein zf-C4H2 PF10146.9 EFO60931.1 - 5.7 7.2 14.9 1.1 9.5 1.3 2.2 1 1 1 2 2 2 0 Zinc finger-containing protein Fungal_TACC PF12709.7 EFO60931.1 - 6.2 7.4 8.8 25 5.4 2.3 3.1 3 1 0 3 3 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins OmpH PF03938.14 EFO60931.1 - 6.9 7.0 14.5 9.8 6.5 8.5 2.6 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) CENP-F_leu_zip PF10473.9 EFO60931.1 - 7.5 6.6 15.7 2.1 8.4 5.7 3.0 2 1 2 4 4 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Uso1_p115_C PF04871.13 EFO60931.1 - 9.4 6.6 9.5 91 3.4 9.5 2.2 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Pkinase PF00069.25 EFO60932.1 - 5.5e-69 232.5 0.0 7.7e-69 232.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO60932.1 - 1.5e-45 155.5 0.0 2.1e-45 155.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO60932.1 - 1e-07 31.6 0.1 3.5e-07 29.8 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EFO60932.1 - 0.0036 17.3 0.1 0.019 14.9 0.1 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFO60932.1 - 0.0042 16.1 1.5 0.011 14.8 0.4 2.2 2 1 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 EFO60932.1 - 0.015 14.7 0.3 0.036 13.4 0.3 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFO60932.1 - 0.089 12.4 0.1 0.21 11.1 0.1 1.7 1 0 0 1 1 1 0 RIO1 family NGP1NT PF08153.12 EFO60933.1 - 2.8e-35 121.3 0.3 6.5e-35 120.1 0.3 1.7 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EFO60933.1 - 7.5e-15 55.0 0.0 1.8e-12 47.3 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFO60933.1 - 9.3e-07 28.9 0.0 2.4e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 EFO60933.1 - 7.5e-05 22.8 1.8 0.051 13.6 0.0 3.9 2 2 1 3 3 3 2 Dynamin family FeoB_N PF02421.18 EFO60933.1 - 0.00011 21.8 0.1 0.0008 19.0 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.21 EFO60933.1 - 0.043 13.3 0.0 3.7 7.0 0.0 2.5 2 0 0 2 2 2 0 ADP-ribosylation factor family Ephrin_rec_like PF07699.13 EFO60934.1 - 8.9e-24 83.0 50.6 2.8e-13 49.4 9.5 5.3 2 1 3 5 5 5 4 Putative ephrin-receptor like NCD3G PF07562.14 EFO60934.1 - 0.00017 21.5 31.7 0.0089 16.0 4.9 4.9 1 1 4 6 6 6 4 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 EFO60934.1 - 0.086 13.3 0.5 0.086 13.3 0.5 5.5 4 2 1 5 5 5 0 TNFR/NGFR cysteine-rich region Ank_2 PF12796.7 EFO60935.1 - 5.2e-14 52.6 5.4 1e-11 45.3 0.0 3.8 2 2 1 3 3 3 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO60935.1 - 1.3e-10 41.3 0.2 2.8e-06 27.5 0.0 3.9 3 1 1 4 4 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO60935.1 - 2.1e-07 31.0 0.1 0.044 14.3 0.0 4.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EFO60935.1 - 2.3e-06 27.5 0.7 0.068 13.8 0.0 5.1 4 0 0 4 4 4 1 Ankyrin repeat DUF4201 PF13870.6 EFO60935.1 - 0.0062 16.3 0.9 0.0062 16.3 0.9 4.2 4 1 0 4 4 4 1 Domain of unknown function (DUF4201) Ank_4 PF13637.6 EFO60935.1 - 0.032 14.8 0.1 0.25 12.0 0.0 2.7 2 1 0 2 2 2 0 Ankyrin repeats (many copies) SpoIISA_toxin PF14171.6 EFO60935.1 - 0.48 10.1 3.9 0.33 10.6 0.5 2.3 2 0 0 2 2 2 0 Toxin SpoIISA, type II toxin-antitoxin system Prp19 PF08606.11 EFO60935.1 - 2.8 8.0 7.5 0.43 10.6 0.3 3.4 3 1 0 3 3 3 0 Prp19/Pso4-like MCPVI PF02993.14 EFO60935.1 - 2.9 7.7 8.0 0.32 10.8 1.9 2.2 1 1 1 2 2 2 0 Minor capsid protein VI Spc7 PF08317.11 EFO60935.1 - 6 5.7 29.7 1.4 7.8 9.2 3.8 4 0 0 4 4 4 0 Spc7 kinetochore protein FAM76 PF16046.5 EFO60935.1 - 6.3 6.1 15.5 2.7 7.3 4.8 3.1 3 0 0 3 3 3 0 FAM76 protein TPR_19 PF14559.6 EFO60936.1 - 2.5e-11 43.9 0.6 0.00017 22.0 0.1 4.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFO60936.1 - 5e-09 35.6 0.5 1.4 9.2 0.0 8.2 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFO60936.1 - 1.9e-07 31.3 0.1 2.9 8.9 0.2 6.4 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFO60936.1 - 8.2e-07 28.6 0.1 0.53 10.2 0.1 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFO60936.1 - 0.00076 19.5 13.6 0.69 10.3 0.0 8.3 10 0 0 10 10 8 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFO60936.1 - 0.0012 18.7 1.7 47 4.3 0.0 6.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFO60936.1 - 0.0047 17.6 0.5 37 5.1 0.0 5.0 4 1 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFO60936.1 - 0.0099 16.1 1.6 2 8.7 2.1 4.5 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EFO60936.1 - 0.043 14.5 1.9 8.8 7.2 0.1 5.1 5 0 0 5 5 4 0 Tetratricopeptide repeat RPN7 PF10602.9 EFO60936.1 - 0.12 12.1 1.4 0.7 9.6 0.2 2.9 4 0 0 4 4 4 0 26S proteasome subunit RPN7 TPR_21 PF09976.9 EFO60936.1 - 0.58 9.8 2.5 1 9.0 0.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain TPR_11 PF13414.6 EFO60936.1 - 1 9.1 8.4 48 3.8 0.1 5.9 7 0 0 7 7 7 0 TPR repeat Pkinase PF00069.25 EFO60937.1 - 4.1e-11 42.8 0.0 1.4e-10 41.0 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO60937.1 - 1.1e-05 24.8 1.1 0.0002 20.7 1.1 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase tRNA-synt_1_2 PF13603.6 EFO60937.1 - 0.14 11.7 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 Adaptin_N PF01602.20 EFO60938.1 - 4.6e-40 137.7 10.7 6.8e-40 137.1 10.7 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EFO60938.1 - 3.8e-17 62.8 9.7 7.2e-15 55.4 5.8 3.3 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFO60938.1 - 4.1e-06 26.6 3.5 0.36 11.2 0.1 6.2 7 0 0 7 7 7 2 HEAT repeat HEAT_2 PF13646.6 EFO60938.1 - 1.4e-05 25.4 4.5 0.006 16.9 0.1 3.8 3 1 2 5 5 5 2 HEAT repeats HEAT_EZ PF13513.6 EFO60938.1 - 0.042 14.4 0.4 6.4 7.4 0.0 4.0 3 1 1 4 4 4 0 HEAT-like repeat CUT PF02376.15 EFO60938.1 - 0.11 12.6 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 CUT domain API5 PF05918.11 EFO60938.1 - 0.13 11.1 0.3 0.29 9.9 0.3 1.5 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Ubiq-Cytc-red_N PF09165.10 EFO60939.1 - 0.023 15.6 0.1 0.098 13.6 0.1 2.1 1 0 0 1 1 1 0 Ubiquinol-cytochrome c reductase 8 kDa, N-terminal Ank_2 PF12796.7 EFO60940.1 - 1.6e-24 86.3 8.5 8.1e-09 36.0 0.0 5.6 3 2 3 6 6 6 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO60940.1 - 5.3e-16 58.5 4.6 0.00019 21.6 0.0 5.9 5 1 1 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60940.1 - 1.1e-11 43.9 0.5 0.43 11.3 0.0 7.4 8 0 0 8 8 7 3 Ankyrin repeat Ank_4 PF13637.6 EFO60940.1 - 7.3e-11 42.4 3.8 0.0085 16.7 0.1 6.7 4 2 4 8 8 8 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO60940.1 - 9.4e-10 38.5 0.5 1.9 9.1 0.0 6.5 4 2 1 5 5 5 2 Ankyrin repeat Macoilin PF09726.9 EFO60940.1 - 0.033 12.8 7.9 0.063 11.8 7.9 1.4 1 0 0 1 1 1 0 Macoilin family FapA PF03961.13 EFO60940.1 - 0.13 10.9 8.2 0.29 9.7 0.8 2.2 2 0 0 2 2 2 0 Flagellar Assembly Protein A bZIP_1 PF00170.21 EFO60940.1 - 0.21 11.7 5.2 3.2 7.9 0.1 3.2 2 1 1 3 3 3 0 bZIP transcription factor UPF0242 PF06785.11 EFO60940.1 - 0.49 10.5 10.8 0.52 10.4 1.0 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF4559 PF15112.6 EFO60940.1 - 0.73 9.5 6.4 0.093 12.4 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) YabA PF06156.13 EFO60940.1 - 4.2 8.1 6.9 33 5.2 1.0 3.0 2 0 0 2 2 2 0 Initiation control protein YabA CC2-LZ PF16516.5 EFO60940.1 - 5.4 7.5 8.8 0.97 9.8 0.8 3.3 2 2 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Ank_2 PF12796.7 EFO60941.1 - 2.5e-11 44.0 0.0 3.4e-07 30.7 0.0 3.0 2 1 1 3 3 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO60941.1 - 3.2e-05 24.0 0.1 1.2 9.9 0.0 4.6 5 0 0 5 5 4 1 Ankyrin repeat Ank_4 PF13637.6 EFO60941.1 - 0.0002 21.9 0.1 0.018 15.6 0.0 3.1 3 0 0 3 3 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO60941.1 - 0.0003 21.0 0.0 0.32 11.4 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO60941.1 - 0.0013 19.1 0.1 0.38 11.3 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat GAS PF13851.6 EFO60941.1 - 0.038 13.3 4.6 0.047 13.0 0.3 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding 4HB_MCP_1 PF12729.7 EFO60941.1 - 0.053 13.1 0.3 0.053 13.1 0.3 2.2 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction CENP-H PF05837.12 EFO60941.1 - 0.11 12.9 4.5 1.4 9.4 0.6 2.8 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Spc7 PF08317.11 EFO60941.1 - 0.13 11.1 6.4 0.87 8.4 0.9 2.4 2 0 0 2 2 2 0 Spc7 kinetochore protein PRKG1_interact PF15898.5 EFO60941.1 - 0.14 13.0 6.6 4.3 8.3 0.1 3.0 3 0 0 3 3 2 0 cGMP-dependent protein kinase interacting domain DUF948 PF06103.11 EFO60941.1 - 0.16 12.2 7.5 1.2 9.5 1.3 3.4 2 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) CdvA PF18822.1 EFO60941.1 - 0.54 10.1 7.9 3.6 7.4 2.0 3.1 2 1 0 2 2 2 0 CdvA-like coiled-coil domain Takusan PF04822.13 EFO60941.1 - 0.56 10.1 4.4 8.1 6.4 4.4 2.6 1 1 0 1 1 1 0 Takusan Rx_N PF18052.1 EFO60941.1 - 5.5 7.3 6.8 2.1 8.7 0.9 3.0 2 1 1 3 3 3 0 Rx N-terminal domain ApoLp-III PF07464.11 EFO60941.1 - 8.9 6.4 10.4 27 4.8 0.7 4.1 2 2 1 4 4 4 0 Apolipophorin-III precursor (apoLp-III) zf-RING_9 PF13901.6 EFO60942.1 - 1.9e-13 50.9 6.1 3.3e-13 50.1 6.1 1.4 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon Herpes_gE PF02480.16 EFO60943.1 - 0.051 12.3 0.0 0.064 12.0 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Bac_export_2 PF01312.19 EFO60943.1 - 0.12 11.5 1.6 0.19 10.9 1.6 1.3 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family DUF3671 PF12420.8 EFO60943.1 - 1 9.4 7.8 0.55 10.3 2.2 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF2721 PF11026.8 EFO60943.1 - 1.5 8.7 15.1 4.6 7.1 1.2 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2721) TMIE PF16038.5 EFO60943.1 - 2.1 8.3 8.5 0.09 12.6 2.3 1.9 2 0 0 2 2 2 0 TMIE protein DUF5113 PF17140.4 EFO60943.1 - 7.4 6.3 7.2 8.8 6.1 0.3 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5113) Myb_DNA-bind_7 PF15963.5 EFO60944.1 - 0.033 14.1 0.1 0.068 13.1 0.1 1.4 1 0 0 1 1 1 0 Myb DNA-binding like DNA_pol_phi PF04931.13 EFO60944.1 - 9.8 4.1 7.3 16 3.5 7.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi Fip1 PF05182.13 EFO60946.1 - 4.4e-05 22.9 0.3 4.4e-05 22.9 0.3 1.8 2 0 0 2 2 2 1 Fip1 motif AMP_N PF05195.16 EFO60947.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Aminopeptidase P, N-terminal domain PQQ_3 PF13570.6 EFO60948.1 - 0.11 13.0 0.5 3.8 8.1 0.0 3.0 2 0 0 2 2 2 0 PQQ-like domain Enolase_C PF00113.22 EFO60949.1 - 4e-109 364.4 0.0 5.4e-109 364.0 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EFO60949.1 - 4.5e-50 169.2 0.0 6.9e-50 168.6 0.0 1.3 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EFO60949.1 - 1.5e-05 24.7 0.0 2.3e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like DUF1611_N PF17396.2 EFO60949.1 - 0.012 15.8 0.0 0.29 11.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1611_N) Rossmann-like domain MAAL_C PF07476.11 EFO60949.1 - 0.034 13.3 0.0 0.061 12.5 0.0 1.3 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus Kelch_4 PF13418.6 EFO60950.1 - 4.1e-16 58.7 10.3 1.3e-08 34.7 0.0 5.9 5 1 1 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.25 EFO60950.1 - 4.2e-15 55.0 18.5 4.4e-07 29.4 0.1 5.5 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 EFO60950.1 - 5.5e-15 55.0 9.8 4.8e-07 29.8 0.1 5.7 5 1 1 6 6 6 3 Kelch motif Kelch_3 PF13415.6 EFO60950.1 - 5.9e-11 42.4 5.2 0.00027 21.1 0.0 4.2 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EFO60950.1 - 6.2e-11 42.0 11.1 0.001 19.0 0.0 5.3 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 EFO60950.1 - 1.9e-08 34.0 13.8 1.9e-05 24.4 0.0 5.6 6 0 0 6 6 6 3 Kelch motif RCC1 PF00415.18 EFO60950.1 - 0.001 19.7 2.6 0.0063 17.1 0.1 2.8 2 0 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat RdRP_1 PF00680.20 EFO60950.1 - 0.12 10.9 0.0 0.17 10.4 0.0 1.1 1 0 0 1 1 1 0 RNA dependent RNA polymerase MCM PF00493.23 EFO60951.1 - 5.1e-80 267.8 0.7 8.2e-80 267.1 0.7 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFO60951.1 - 4.3e-28 97.7 0.3 9.9e-28 96.5 0.3 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFO60951.1 - 6.7e-21 74.5 0.1 2.5e-20 72.7 0.0 2.1 2 0 0 2 2 2 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EFO60951.1 - 1.7e-08 34.1 0.4 1.7e-06 27.6 0.4 2.5 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 EFO60951.1 - 2.2e-08 34.6 1.4 2.5e-07 31.2 0.1 2.8 2 0 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.14 EFO60951.1 - 6.6e-06 26.2 0.0 1.5e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFO60951.1 - 0.00019 21.3 0.0 0.00096 19.0 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFO60951.1 - 0.00055 19.7 0.2 0.0019 17.9 0.2 1.8 1 1 0 1 1 1 1 Sigma-54 interaction domain Dynactin_p22 PF07426.11 EFO60951.1 - 0.019 14.9 0.1 0.044 13.6 0.1 1.6 1 0 0 1 1 1 0 Dynactin subunit p22 AAA_16 PF13191.6 EFO60951.1 - 0.019 15.3 0.4 1.3 9.4 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 EFO60951.1 - 0.02 14.6 0.1 0.059 13.1 0.1 1.7 2 0 0 2 2 2 0 AAA domain DUF2203 PF09969.9 EFO60951.1 - 0.076 13.7 0.1 0.19 12.5 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) AAA PF00004.29 EFO60951.1 - 0.21 12.0 0.6 0.59 10.6 0.1 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Ank_2 PF12796.7 EFO60952.1 - 9.4e-43 144.7 9.7 2.8e-13 50.3 0.3 5.7 4 2 2 6 6 6 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO60952.1 - 5.7e-24 81.6 4.3 0.017 15.6 0.0 9.4 9 0 0 9 9 8 5 Ankyrin repeat Ank_5 PF13857.6 EFO60952.1 - 4.1e-23 81.2 9.5 0.00048 20.4 0.1 7.7 4 2 3 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO60952.1 - 8.1e-22 76.7 3.2 0.025 15.0 0.0 8.7 8 0 0 8 8 8 4 Ankyrin repeat Ank_4 PF13637.6 EFO60952.1 - 4.2e-16 59.1 5.1 0.015 15.8 0.1 6.1 5 1 0 5 5 5 4 Ankyrin repeats (many copies) DUF3552 PF12072.8 EFO60952.1 - 0.00041 19.8 2.2 0.17 11.3 0.5 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF3552) HAP1_N PF04849.13 EFO60952.1 - 0.018 14.2 0.6 0.018 14.2 0.6 2.6 3 0 0 3 3 3 0 HAP1 N-terminal conserved region FlgN PF05130.12 EFO60952.1 - 0.067 13.7 4.2 0.96 10.0 0.2 3.1 2 0 0 2 2 2 0 FlgN protein Phage_GP20 PF06810.11 EFO60952.1 - 0.12 12.2 2.7 0.14 12.0 0.5 2.3 2 0 0 2 2 1 0 Phage minor structural protein GP20 FliJ PF02050.16 EFO60952.1 - 0.18 12.0 11.2 0.11 12.8 0.4 3.7 4 0 0 4 4 4 0 Flagellar FliJ protein HrpB7 PF09486.10 EFO60952.1 - 0.29 11.5 4.7 0.67 10.3 1.4 2.5 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) SlyX PF04102.12 EFO60952.1 - 0.31 11.7 2.4 8.7 7.0 2.0 3.1 2 0 0 2 2 2 0 SlyX Atg14 PF10186.9 EFO60952.1 - 0.64 9.1 4.2 0.18 10.9 0.4 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cep57_MT_bd PF06657.13 EFO60952.1 - 0.88 10.1 5.0 3.2 8.3 0.4 3.4 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Sec20 PF03908.13 EFO60952.1 - 0.98 9.4 3.5 1.9 8.5 0.2 3.0 2 0 0 2 2 2 0 Sec20 Syntaxin-6_N PF09177.11 EFO60952.1 - 3.8 8.1 5.5 37 5.0 0.2 3.8 4 0 0 4 4 3 0 Syntaxin 6, N-terminal FlxA PF14282.6 EFO60952.1 - 4 7.5 10.5 2.6 8.1 0.3 3.1 2 0 0 2 2 2 0 FlxA-like protein ABC_tran_CTD PF16326.5 EFO60952.1 - 4.7 7.5 10.4 14 6.0 0.0 3.1 3 0 0 3 3 2 0 ABC transporter C-terminal domain HIP1_clath_bdg PF16515.5 EFO60952.1 - 6.8 7.4 10.1 2.5 8.8 1.0 3.9 4 0 0 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 APG6_N PF17675.1 EFO60952.1 - 7.4 7.1 13.5 0.52 10.8 0.6 3.4 3 1 0 3 3 3 0 Apg6 coiled-coil region LRR_9 PF14580.6 EFO60953.1 - 1.4e-14 53.9 0.0 8.8e-14 51.4 0.0 2.3 2 0 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 EFO60953.1 - 1.3e-08 35.0 3.3 8.5e-05 22.9 0.3 3.1 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO60953.1 - 2.7e-06 27.0 1.7 5e-06 26.2 0.7 2.0 2 0 0 2 2 2 1 Leucine rich repeat HALZ PF02183.18 EFO60953.1 - 0.013 15.8 1.4 0.096 12.9 0.4 3.1 2 0 0 2 2 2 0 Homeobox associated leucine zipper DivIVA PF05103.13 EFO60953.1 - 3.6 7.7 29.2 0.023 14.8 7.1 3.8 1 1 2 3 3 3 0 DivIVA protein Acetyltransf_1 PF00583.25 EFO60954.1 - 3.4e-15 56.3 0.0 3.8e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFO60954.1 - 8e-09 35.5 0.0 1.1e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFO60954.1 - 1e-07 32.3 0.0 3e-07 30.8 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFO60954.1 - 0.0031 17.6 0.0 0.0035 17.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFO60954.1 - 0.071 13.2 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase FR47 PF08445.10 EFO60954.1 - 0.095 12.7 0.0 0.22 11.5 0.0 1.6 2 0 0 2 2 2 0 FR47-like protein MRP-S34 PF16053.5 EFO60954.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S34 DHH PF01368.20 EFO60955.1 - 8.5e-21 74.1 0.0 2.6e-20 72.5 0.0 1.8 1 1 0 1 1 1 1 DHH family CBS PF00571.28 EFO60955.1 - 1.3e-10 41.6 0.0 0.00085 19.7 0.0 3.0 2 0 0 2 2 2 2 CBS domain DHHA2 PF02833.14 EFO60955.1 - 3.5e-07 30.5 0.0 6.6e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 DHHA2 domain PP2C PF00481.21 EFO60957.1 - 1.2e-43 149.7 0.0 5.9e-43 147.3 0.0 1.9 2 0 0 2 2 2 1 Protein phosphatase 2C Lin-8 PF03353.15 EFO60957.1 - 0.15 11.6 0.1 0.24 10.9 0.1 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist RNA_pol_Rpb5_C PF01191.19 EFO60958.1 - 4.2e-26 90.6 0.0 7.6e-26 89.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EFO60958.1 - 0.17 12.5 0.0 0.35 11.5 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb5, N-terminal domain CCDC158 PF15921.5 EFO60959.1 - 0.15 9.8 0.0 0.2 9.4 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 158 Pkinase PF00069.25 EFO60960.1 - 3.8e-23 82.2 0.0 5.4e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO60960.1 - 8.4e-12 44.9 0.0 1.3e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFO60961.1 - 1.4e-66 224.6 0.1 3.1e-66 223.4 0.0 1.7 2 0 0 2 2 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO60961.1 - 6.3e-42 143.6 0.0 1.3e-41 142.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO60961.1 - 2.5e-31 108.1 0.7 6.8e-11 42.6 0.0 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO60961.1 - 3.6e-23 81.3 0.4 8e-06 26.0 0.0 5.5 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO60961.1 - 7.4e-19 67.9 0.6 5e-06 27.0 0.1 5.4 4 2 2 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO60961.1 - 1.8e-17 62.9 1.1 0.11 13.0 0.0 7.0 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 EFO60961.1 - 3.1e-15 54.7 0.3 0.12 13.0 0.0 6.5 6 0 0 6 6 6 3 Ankyrin repeat DUF4407 PF14362.6 EFO60961.1 - 0.00078 18.9 2.9 0.0012 18.2 2.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) CALCOCO1 PF07888.11 EFO60961.1 - 0.0032 16.4 12.0 0.0044 15.9 12.0 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Atg14 PF10186.9 EFO60961.1 - 0.004 16.3 6.4 0.007 15.5 6.4 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 FTA2 PF13095.6 EFO60961.1 - 0.0081 15.8 0.1 0.11 12.1 0.1 2.6 1 1 1 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EFO60961.1 - 0.0094 15.9 0.0 0.035 14.0 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFO60961.1 - 0.0097 15.2 1.1 0.029 13.7 0.0 2.2 3 0 0 3 3 3 1 Kinase-like AAA_13 PF13166.6 EFO60961.1 - 0.018 13.7 3.5 0.024 13.3 3.5 1.1 1 0 0 1 1 1 0 AAA domain Herpes_UL6 PF01763.16 EFO60961.1 - 0.04 12.4 4.9 0.086 11.3 4.5 1.7 2 0 0 2 2 2 0 Herpesvirus UL6 like ATG16 PF08614.11 EFO60961.1 - 0.066 13.4 18.0 0.55 10.4 17.8 2.2 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) OmpH PF03938.14 EFO60961.1 - 0.078 13.3 9.2 0.16 12.3 9.2 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Exonuc_VII_L PF02601.15 EFO60961.1 - 0.12 12.0 5.1 0.2 11.2 5.1 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Seryl_tRNA_N PF02403.22 EFO60961.1 - 0.12 12.6 8.1 4.3 7.6 7.7 2.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain SlyX PF04102.12 EFO60961.1 - 0.15 12.7 14.4 0.087 13.5 9.7 2.6 1 1 1 2 2 2 0 SlyX DUF812 PF05667.11 EFO60961.1 - 0.19 10.6 12.8 0.28 10.0 12.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Spc7 PF08317.11 EFO60961.1 - 0.2 10.5 15.3 0.37 9.6 13.5 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Choline_kinase PF01633.20 EFO60961.1 - 0.25 10.9 2.8 2 7.9 0.0 2.5 2 1 0 2 2 2 0 Choline/ethanolamine kinase GAS PF13851.6 EFO60961.1 - 0.27 10.6 13.5 0.76 9.1 13.5 1.7 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding COG2 PF06148.11 EFO60961.1 - 0.35 10.9 4.3 0.84 9.7 4.3 1.6 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF641 PF04859.12 EFO60961.1 - 0.37 11.1 12.6 0.16 12.3 3.9 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Csm1_N PF18504.1 EFO60961.1 - 1 9.7 12.1 0.99 9.8 2.7 2.7 2 0 0 2 2 2 0 Csm1 N-terminal domain DUF16 PF01519.16 EFO60961.1 - 1.4 9.4 8.4 4.5 7.8 8.3 1.9 1 1 0 1 1 1 0 Protein of unknown function DUF16 Phage_lysis PF03245.13 EFO60961.1 - 1.8 8.7 9.1 0.95 9.6 4.7 2.5 1 1 1 2 2 2 0 Bacteriophage Rz lysis protein BLOC1_2 PF10046.9 EFO60961.1 - 2.4 8.5 10.6 8.5 6.7 0.8 2.7 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DivIC PF04977.15 EFO60961.1 - 2.9 7.7 14.9 1.7 8.5 4.8 3.2 2 1 1 3 3 3 0 Septum formation initiator Cep57_CLD_2 PF14197.6 EFO60961.1 - 3.4 7.8 14.8 0.077 13.1 5.2 2.4 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 V_ATPase_I PF01496.19 EFO60961.1 - 7 4.4 6.9 3 5.6 3.6 1.8 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family FlaC_arch PF05377.11 EFO60961.1 - 7.6 7.0 6.6 12 6.4 1.8 2.7 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) APG6_N PF17675.1 EFO60961.1 - 9.8 6.7 17.2 53 4.3 14.4 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region Cyt-b5 PF00173.28 EFO60962.1 - 1.7e-09 37.7 0.0 2.8e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ubiquitin PF00240.23 EFO60962.1 - 5e-05 23.0 0.0 9.2e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFO60962.1 - 0.02 14.7 0.0 0.033 14.0 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Baculo_PEP_C PF04513.12 EFO60964.1 - 0.1 12.6 0.1 0.19 11.8 0.1 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus BBL5 PF07289.11 EFO60965.1 - 7.6e-39 133.7 0.5 5e-35 121.1 0.2 2.7 2 1 0 2 2 2 2 Bardet-Biedl syndrome 5 protein Vps36_ESCRT-II PF11605.8 EFO60965.1 - 5.5e-10 39.3 0.1 0.002 18.2 0.0 2.7 2 1 0 2 2 2 2 Vacuolar protein sorting protein 36 Vps36 PH_TFIIH PF08567.11 EFO60965.1 - 0.0017 18.6 0.0 0.14 12.5 0.0 2.6 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain Voldacs PF03517.13 EFO60965.1 - 0.014 15.5 0.1 0.051 13.7 0.0 1.9 2 1 0 2 2 2 0 Regulator of volume decrease after cellular swelling SDF PF00375.18 EFO60966.1 - 0.013 14.5 0.1 0.47 9.4 0.1 2.0 1 1 1 2 2 2 0 Sodium:dicarboxylate symporter family mRNA_decap_C PF16741.5 EFO60966.1 - 0.016 14.5 0.6 0.079 12.3 0.1 2.4 2 0 0 2 2 2 0 mRNA-decapping enzyme C-terminus CFAP91 PF14738.6 EFO60969.1 - 1.5e-24 86.8 12.0 1.5e-24 86.8 12.0 2.6 3 0 0 3 3 3 1 Cilia- and flagella-associated protein 91 CopG_antitoxin PF12441.8 EFO60969.1 - 1 9.9 5.2 4 8.0 0.3 2.8 1 1 1 2 2 2 0 CopG antitoxin of type II toxin-antitoxin system FtsJ PF01728.19 EFO60970.1 - 0.0014 18.8 0.0 0.003 17.7 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase Ank_2 PF12796.7 EFO60972.1 - 3.1e-96 316.1 25.4 1.8e-12 47.7 0.1 10.6 2 2 7 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO60972.1 - 2.6e-54 180.9 34.5 2.6e-07 31.0 0.5 15.6 7 4 9 16 16 16 14 Ankyrin repeats (many copies) Ank PF00023.30 EFO60972.1 - 2.4e-51 170.0 35.2 0.00028 21.2 0.0 18.4 18 1 1 19 19 19 13 Ankyrin repeat Ank_5 PF13857.6 EFO60972.1 - 2.3e-46 155.3 33.5 2.3e-05 24.6 0.1 15.6 8 5 8 17 17 16 12 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60972.1 - 1.3e-45 148.1 27.0 0.0068 16.8 0.0 19.8 21 0 0 21 21 21 11 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO60972.1 - 6.8e-13 48.3 7.4 1.6e-12 47.1 7.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO60972.1 - 1.9e-06 27.7 6.8 4.2e-06 26.5 6.8 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EFO60972.1 - 9.1e-05 22.3 7.8 0.00033 20.5 7.8 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFO60972.1 - 0.00015 22.0 8.8 0.00054 20.2 8.8 2.1 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFO60972.1 - 0.0064 16.3 7.6 0.024 14.5 7.6 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFO60972.1 - 0.09 12.8 7.8 0.077 13.0 5.8 2.1 2 0 0 2 2 2 0 zinc-RING finger domain VSP PF03302.13 EFO60973.1 - 5.2e-42 144.1 182.6 1e-31 110.2 53.1 7.9 1 1 6 7 7 7 7 Giardia variant-specific surface protein RVT_1 PF00078.27 EFO60974.1 - 8.5e-12 45.1 0.0 1.7e-05 24.5 0.0 2.0 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Ank_2 PF12796.7 EFO60975.1 - 4.7e-57 190.5 0.1 9.1e-16 58.2 0.0 4.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO60975.1 - 6.6e-36 122.2 0.9 2.2e-08 34.5 0.0 7.7 5 3 3 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO60975.1 - 8.7e-31 105.0 0.0 0.00045 20.5 0.0 9.1 9 0 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 EFO60975.1 - 1.8e-30 104.6 3.3 0.00027 21.2 0.0 8.4 1 1 7 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60975.1 - 5.2e-25 84.8 0.1 0.035 14.7 0.0 8.8 9 0 0 9 9 9 5 Ankyrin repeat Pkinase PF00069.25 EFO60975.1 - 9e-19 67.8 0.0 1.7e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO60975.1 - 4.5e-09 36.0 0.0 7.3e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase zf-C2H2_jaz PF12171.8 EFO60976.1 - 0.02 15.2 0.2 0.041 14.2 0.2 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Ank_2 PF12796.7 EFO60978.1 - 1.2e-103 339.8 7.2 4.6e-15 56.0 0.0 5.2 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO60978.1 - 1.6e-38 130.6 3.1 3.7e-11 43.3 0.0 6.8 5 2 2 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO60978.1 - 8.7e-31 105.0 0.3 0.0015 18.8 0.0 8.9 8 1 0 8 8 8 7 Ankyrin repeat Ank_5 PF13857.6 EFO60978.1 - 1.6e-28 98.4 5.7 6.1e-05 23.2 0.1 7.7 2 1 6 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60978.1 - 8.6e-25 84.1 0.4 0.14 12.8 0.0 9.4 9 0 0 9 9 9 6 Ankyrin repeat Pkinase PF00069.25 EFO60978.1 - 3.2e-17 62.8 0.0 1.6e-16 60.5 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO60978.1 - 2.7e-12 46.5 0.0 4.7e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase T3SSipB PF16535.5 EFO60978.1 - 3 8.3 5.5 4.9 7.6 5.5 1.2 1 0 0 1 1 1 0 Type III cell invasion protein SipB Ank_2 PF12796.7 EFO60979.1 - 1.1e-36 125.3 0.5 6.8e-14 52.2 0.0 2.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO60979.1 - 9.6e-23 80.3 3.7 1.8e-08 34.8 0.2 3.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO60979.1 - 2.1e-16 59.6 0.1 0.0098 16.3 0.0 4.3 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 EFO60979.1 - 6.2e-15 55.1 0.8 0.00016 21.9 0.0 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60979.1 - 8.3e-15 53.4 0.1 0.00058 20.1 0.0 4.7 4 1 1 5 5 5 4 Ankyrin repeat SLATT_1 PF18181.1 EFO60979.1 - 0.094 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 Ank_2 PF12796.7 EFO60980.1 - 5.7e-44 148.6 9.6 1.6e-14 54.2 0.1 5.4 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO60980.1 - 8.1e-31 106.0 4.1 1.2e-05 25.8 0.1 7.3 4 1 3 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60980.1 - 3.8e-27 91.3 7.0 0.023 15.2 0.1 9.9 10 0 0 10 10 10 8 Ankyrin repeat Ank_5 PF13857.6 EFO60980.1 - 9.4e-25 86.4 14.8 0.00013 22.2 0.0 9.3 2 1 8 10 10 10 8 Ankyrin repeats (many copies) Ank PF00023.30 EFO60980.1 - 4.8e-22 77.4 8.2 0.097 13.2 0.2 9.2 8 1 0 8 8 8 6 Ankyrin repeat Pkinase PF00069.25 EFO60980.1 - 1.7e-07 30.9 0.1 7.1e-07 28.8 0.0 2.1 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO60980.1 - 6.9e-06 25.5 0.0 1.4e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase VWA_3_C PF18571.1 EFO60980.1 - 0.071 13.0 0.2 48 3.9 0.0 3.5 3 0 0 3 3 3 0 von Willebrand factor type A C-terminal domain Phage_tail_NK PF16532.5 EFO60980.1 - 0.079 12.6 0.2 0.18 11.4 0.2 1.6 1 1 1 2 2 2 0 Sf6-type phage tail needle knob or tip of some Caudovirales Ank_2 PF12796.7 EFO60981.1 - 5.2e-25 87.8 0.0 4.6e-14 52.8 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO60981.1 - 1.9e-15 57.0 1.7 2e-06 28.2 0.1 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60981.1 - 2.9e-15 54.8 0.3 0.0017 18.7 0.0 5.0 4 1 1 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EFO60981.1 - 3.5e-15 55.8 2.9 8.8e-05 22.7 0.0 4.3 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO60981.1 - 5.4e-15 55.1 0.1 0.001 19.4 0.0 4.2 3 1 1 4 4 4 3 Ankyrin repeat HTH_Tnp_1_2 PF13022.6 EFO60981.1 - 0.029 14.5 0.0 0.063 13.4 0.0 1.5 2 0 0 2 2 2 0 Helix-turn-helix of insertion element transposase Thioredoxin PF00085.20 EFO60982.1 - 8.3e-07 28.9 0.0 1.3e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 EFO60982.1 - 0.0015 17.5 0.1 0.0018 17.3 0.1 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin_6 PF13848.6 EFO60982.1 - 0.045 13.7 0.3 0.063 13.2 0.3 1.3 1 1 0 1 1 1 0 Thioredoxin-like domain Nefa_Nip30_N PF10187.9 EFO60982.1 - 0.089 13.2 0.3 0.13 12.6 0.3 1.2 1 0 0 1 1 1 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 SBDS PF01172.18 EFO60983.1 - 2.7e-16 59.4 0.3 4.1e-16 58.8 0.3 1.3 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Glycos_transf_4 PF00953.21 EFO60984.1 - 1.8e-32 112.6 5.9 1.8e-32 112.6 5.9 2.1 3 0 0 3 3 3 1 Glycosyl transferase family 4 COX7a PF02238.15 EFO60984.1 - 2.5 8.5 4.3 1.1 9.7 0.1 2.6 3 0 0 3 3 3 0 Cytochrome c oxidase subunit VII KIAA1328 PF15369.6 EFO60985.1 - 0.0019 18.1 1.3 0.0043 17.0 1.3 1.6 1 0 0 1 1 1 1 Uncharacterised protein KIAA1328 CASP_C PF08172.12 EFO60985.1 - 0.0037 16.7 0.6 0.0086 15.5 0.6 1.6 1 0 0 1 1 1 1 CASP C terminal Pilus_CpaD PF09476.10 EFO60987.1 - 0.0054 16.5 0.0 0.0064 16.2 0.0 1.0 1 0 0 1 1 1 1 Pilus biogenesis CpaD protein (pilus_cpaD) DUF4848 PF16140.5 EFO60987.1 - 0.041 13.4 0.2 1.2 8.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4848) ATP-synt_ab_C PF00306.27 EFO60987.1 - 0.057 13.8 0.2 3.3 8.0 0.0 2.0 1 1 1 2 2 2 0 ATP synthase alpha/beta chain, C terminal domain TPR_12 PF13424.6 EFO60990.1 - 0.0016 18.7 2.1 0.0045 17.2 0.2 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat NOA36 PF06524.12 EFO60990.1 - 0.18 11.1 5.9 0.52 9.6 5.4 1.9 2 0 0 2 2 2 0 NOA36 protein Alpha-amylase_C PF02806.18 EFO60991.1 - 5.5e-17 62.0 0.1 1.3e-16 60.9 0.1 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 EFO60991.1 - 2.1e-14 53.9 0.1 6.1e-09 35.9 0.1 2.5 1 1 1 2 2 2 2 Alpha amylase, catalytic domain CBM_48 PF02922.18 EFO60991.1 - 4.2e-07 30.2 0.0 1.4e-06 28.5 0.0 1.9 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) IFT20 PF14931.6 EFO60994.1 - 1.7e-05 25.0 2.5 1.9e-05 24.8 2.5 1.1 1 0 0 1 1 1 1 Intraflagellar transport complex B, subunit 20 MOZ_SAS PF01853.18 EFO60995.1 - 3.5e-61 206.0 3.3 3.4e-59 199.5 3.3 2.2 1 1 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EFO60995.1 - 3.6e-16 58.5 3.0 3.6e-16 58.5 3.0 2.1 2 0 0 2 2 2 1 MYST family zinc finger domain Tudor-knot PF11717.8 EFO60995.1 - 0.00048 19.9 0.0 0.0015 18.4 0.0 1.9 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Ank_2 PF12796.7 EFO60996.1 - 6.3e-66 219.0 16.5 3.9e-16 59.4 0.1 6.3 2 1 6 8 8 8 6 Ankyrin repeats (3 copies) Ank PF00023.30 EFO60996.1 - 4.6e-34 115.4 4.7 0.0009 19.6 0.0 10.3 10 0 0 10 10 10 8 Ankyrin repeat Ank_5 PF13857.6 EFO60996.1 - 4.6e-32 109.7 11.5 7.5e-05 22.9 0.0 9.0 2 1 7 9 9 9 8 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO60996.1 - 1.2e-28 99.1 5.2 3.6e-05 24.2 0.3 8.2 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO60996.1 - 1.1e-25 86.8 2.3 0.03 14.9 0.0 9.8 10 0 0 10 10 10 7 Ankyrin repeat Tape_meas_lam_C PF09718.10 EFO60996.1 - 0.15 12.2 0.4 1.8 8.7 0.1 2.7 3 0 0 3 3 3 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) RPN1_RPN2_N PF17781.1 EFO60997.1 - 8.1e-20 71.4 2.3 8.1e-20 71.4 2.3 1.9 2 0 0 2 2 2 1 RPN1/RPN2 N-terminal domain PC_rep PF01851.22 EFO60997.1 - 2.6e-14 52.8 19.4 0.00015 22.0 0.2 6.9 6 0 0 6 6 6 4 Proteasome/cyclosome repeat RPN1_C PF18051.1 EFO60997.1 - 3.8e-08 33.2 0.6 1.1e-07 31.7 0.2 2.0 2 0 0 2 2 2 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal HEAT_2 PF13646.6 EFO60997.1 - 5.6e-06 26.7 0.3 0.051 14.0 0.0 4.3 5 1 1 6 6 6 2 HEAT repeats PBECR2 PF18810.1 EFO60997.1 - 0.063 13.6 0.1 0.13 12.6 0.1 1.5 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease2 MCM PF00493.23 EFO60998.1 - 3.6e-90 301.0 0.1 8.1e-90 299.8 0.1 1.6 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 EFO60998.1 - 1.5e-28 99.0 1.2 2.9e-28 98.1 1.2 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 EFO60998.1 - 5.7e-17 61.7 0.1 1.3e-16 60.6 0.1 1.5 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 EFO60998.1 - 3.1e-09 36.5 0.1 2.1e-07 30.5 0.0 2.7 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 EFO60998.1 - 4.9e-08 33.5 0.0 1.1e-07 32.4 0.0 1.6 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 EFO60998.1 - 0.0017 18.4 0.0 0.0046 17.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFO60998.1 - 0.0099 15.7 0.0 0.026 14.4 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFO60998.1 - 0.011 15.4 0.1 0.03 14.0 0.0 1.7 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_16 PF13191.6 EFO60998.1 - 0.12 12.8 0.5 1.6 9.1 0.1 2.6 2 1 0 2 2 2 0 AAA ATPase domain LRR_4 PF12799.7 EFO60999.1 - 2.1e-10 40.7 9.4 0.0056 17.1 0.1 4.8 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO60999.1 - 1e-06 28.4 10.7 0.48 10.2 0.1 5.0 2 2 4 6 6 6 5 Leucine rich repeat LRR_9 PF14580.6 EFO60999.1 - 0.0017 17.9 0.8 0.18 11.3 0.0 2.2 2 0 0 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.6 EFO60999.1 - 0.063 13.2 0.9 0.17 11.8 0.1 2.1 3 0 0 3 3 3 0 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 EFO60999.1 - 0.17 12.0 9.5 39 4.7 0.2 5.7 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.33 EFO60999.1 - 0.96 10.2 7.1 27 5.8 0.0 5.2 3 1 0 3 3 3 0 Leucine Rich Repeat DNA_pol_D_N PF18018.1 EFO61000.1 - 0.12 12.4 1.7 0.29 11.3 0.4 2.4 2 0 0 2 2 2 0 DNA polymerase delta subunit OB-fold domain Kinesin PF00225.23 EFO61001.1 - 8.4e-90 301.1 0.7 1.5e-89 300.2 0.7 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFO61001.1 - 8e-16 58.3 0.4 4.2e-15 56.0 0.0 2.6 3 0 0 3 3 3 1 Microtubule binding Med21 PF11221.8 EFO61001.1 - 0.041 14.1 0.5 0.041 14.1 0.5 3.2 4 0 0 4 4 4 0 Subunit 21 of Mediator complex FliT PF05400.13 EFO61001.1 - 0.7 10.8 7.6 3.1 8.7 0.4 3.4 2 0 0 2 2 2 0 Flagellar protein FliT LRR_9 PF14580.6 EFO61002.1 - 4.4e-05 23.1 7.0 0.00026 20.5 6.3 2.4 2 1 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 EFO61002.1 - 0.00061 20.1 8.7 0.0033 17.8 0.6 3.3 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO61002.1 - 0.011 15.4 6.5 0.054 13.3 6.5 2.2 1 1 0 1 1 1 0 Leucine rich repeat Dynein_light PF01221.18 EFO61003.1 - 1.1e-18 67.3 0.0 1.3e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 TINF2_N PF14973.6 EFO61003.1 - 0.0009 19.6 0.0 0.0012 19.3 0.0 1.1 1 0 0 1 1 1 1 TERF1-interacting nuclear factor 2 N-terminus F420_ligase PF01996.16 EFO61003.1 - 0.0081 15.5 0.0 0.0087 15.4 0.0 1.1 1 0 0 1 1 1 1 F420-0:Gamma-glutamyl ligase DUF5571 PF17732.1 EFO61003.1 - 0.052 13.0 0.0 0.056 12.9 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5571) Kinesin PF00225.23 EFO61004.1 - 4.5e-89 298.7 8.1 6.4e-88 294.9 4.2 2.8 3 0 0 3 3 3 2 Kinesin motor domain Microtub_bd PF16796.5 EFO61004.1 - 7.6e-37 126.5 2.0 6.6e-33 113.8 2.5 3.5 2 1 0 2 2 2 1 Microtubule binding ubiquitin PF00240.23 EFO61004.1 - 8.6e-06 25.4 0.3 2.7e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin family DUF3618 PF12277.8 EFO61004.1 - 0.15 12.4 2.5 1.5 9.2 1.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3618) Tsc35 PF15079.6 EFO61004.1 - 0.8 9.2 7.5 0.31 10.6 2.7 2.5 2 0 0 2 2 2 0 Testis-specific protein 35 FapA PF03961.13 EFO61004.1 - 1.3 7.5 9.8 1.4 7.4 4.3 2.4 2 0 0 2 2 2 0 Flagellar Assembly Protein A M PF02370.16 EFO61004.1 - 5.8 7.8 6.1 2 9.3 1.4 2.9 2 0 0 2 2 2 0 M protein repeat Pkinase PF00069.25 EFO61005.1 - 2.1e-14 53.6 0.1 1.7e-06 27.6 0.0 2.7 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61005.1 - 6.8e-07 28.8 0.1 0.016 14.5 0.0 2.5 2 1 0 2 2 2 2 Protein tyrosine kinase GCS PF03074.16 EFO61007.1 - 5.1e-64 216.9 0.0 4.2e-63 213.9 0.0 2.0 1 1 0 1 1 1 1 Glutamate-cysteine ligase VSP PF03302.13 EFO61008.1 - 1e-88 297.9 163.4 2.6e-52 178.0 27.4 4.0 1 1 3 4 4 4 4 Giardia variant-specific surface protein DNA_pol_B PF00136.21 EFO61009.1 - 3.9e-82 276.4 0.8 5.6e-82 275.9 0.8 1.2 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 EFO61009.1 - 9.7e-08 32.0 0.0 3.2e-07 30.3 0.0 1.9 1 1 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 EFO61009.1 - 0.08 12.1 0.1 3.2 6.8 0.0 2.8 3 0 0 3 3 3 0 DNA polymerase family B, exonuclease domain mCpol PF18182.1 EFO61009.1 - 0.11 12.9 0.1 0.32 11.4 0.1 1.8 1 0 0 1 1 1 0 minimal CRISPR polymerase domain TSC22 PF01166.18 EFO61010.1 - 0.00025 21.3 1.3 0.00053 20.2 1.3 1.4 1 0 0 1 1 1 1 TSC-22/dip/bun family Shugoshin_N PF07558.11 EFO61010.1 - 0.0031 17.3 4.0 0.0055 16.5 3.5 1.6 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region WD40_alt PF14077.6 EFO61010.1 - 0.01 15.7 1.3 0.02 14.7 1.3 1.4 1 0 0 1 1 1 0 Alternative WD40 repeat motif YabA PF06156.13 EFO61010.1 - 0.044 14.4 0.1 0.088 13.5 0.1 1.5 1 0 0 1 1 1 0 Initiation control protein YabA DUF1192 PF06698.11 EFO61010.1 - 0.052 13.6 0.9 3.8 7.6 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) bZIP_1 PF00170.21 EFO61010.1 - 0.06 13.4 1.0 0.13 12.3 1.0 1.5 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.15 EFO61010.1 - 0.069 13.2 2.8 0.14 12.3 2.8 1.4 1 0 0 1 1 1 0 Basic region leucine zipper Med9 PF07544.13 EFO61010.1 - 0.14 12.2 0.2 1.1 9.4 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Uds1 PF15456.6 EFO61010.1 - 0.77 9.9 4.9 1.4 9.1 1.3 2.4 1 1 1 2 2 2 0 Up-regulated During Septation VSP PF03302.13 EFO61011.1 - 8.1e-84 281.8 293.1 3.4e-32 111.8 29.7 10.4 1 1 9 10 10 10 8 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO61011.1 - 0.49 10.5 1.9 1.9 8.5 0.0 2.6 3 0 0 3 3 3 0 Podoplanin VSP PF03302.13 EFO61012.1 - 2.6e-70 237.3 86.0 8.4e-51 173.1 28.9 5.4 1 1 4 5 5 5 4 Giardia variant-specific surface protein SKG6 PF08693.10 EFO61012.1 - 0.1 12.0 4.8 0.2 11.1 4.8 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Ank_2 PF12796.7 EFO61013.1 - 5.4e-42 142.3 1.9 1.5e-13 51.2 0.1 3.0 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61013.1 - 1.6e-17 63.3 0.6 2.6e-06 27.6 0.0 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61013.1 - 3.6e-16 59.3 0.2 2.1e-06 28.1 0.0 3.5 3 1 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO61013.1 - 3.7e-16 58.8 0.2 0.0016 18.8 0.0 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EFO61013.1 - 2.1e-14 52.2 0.1 0.00039 20.7 0.0 5.2 4 1 1 5 5 5 3 Ankyrin repeat DUF2380 PF09533.10 EFO61013.1 - 0.22 11.1 0.0 0.33 10.6 0.0 1.2 1 0 0 1 1 1 0 Predicted lipoprotein of unknown function (DUF2380) TBCC PF07986.12 EFO61014.1 - 2.5e-12 46.6 10.5 6.5e-12 45.2 10.5 1.6 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 EFO61014.1 - 1.7e-05 24.5 0.9 3e-05 23.7 0.9 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal PVL_ORF50 PF07768.11 EFO61015.1 - 0.0086 16.4 4.8 0.014 15.7 4.8 1.4 1 0 0 1 1 1 1 PVL ORF-50-like family DUF1682 PF07946.14 EFO61015.1 - 0.23 10.6 8.3 0.27 10.4 8.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Kinesin PF00225.23 EFO61016.1 - 1.1e-105 353.3 1.1 2.4e-105 352.2 1.1 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFO61016.1 - 2.4e-22 79.5 1.3 5e-20 72.0 0.0 3.0 2 1 1 3 3 3 2 Microtubule binding CHD5 PF04420.14 EFO61016.1 - 0.22 11.4 2.0 0.83 9.5 2.0 2.0 1 0 0 1 1 1 0 CHD5-like protein DUF1296 PF06972.11 EFO61016.1 - 0.23 11.6 2.9 4.5 7.5 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) FlxA PF14282.6 EFO61016.1 - 0.5 10.4 12.2 3.7 7.6 0.5 3.8 3 0 0 3 3 3 0 FlxA-like protein Peptidase_M41 PF01434.18 EFO61016.1 - 4 7.3 9.9 4.8 7.0 2.5 4.0 3 1 0 3 3 3 0 Peptidase family M41 AAA PF00004.29 EFO61017.1 - 1.5e-33 116.1 0.0 3.4e-33 114.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EFO61017.1 - 5e-26 90.4 0.1 9.3e-26 89.6 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EFO61017.1 - 2.6e-10 39.9 0.1 6.7e-10 38.6 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFO61017.1 - 6.8e-07 29.4 0.6 6.6e-05 22.9 0.1 3.1 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFO61017.1 - 1.8e-05 25.2 0.0 5.4e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.14 EFO61017.1 - 3.2e-05 24.1 0.0 7.6e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 EFO61017.1 - 0.00045 20.8 0.3 0.0022 18.5 0.0 2.3 2 1 1 3 3 3 1 AAA domain DUF815 PF05673.13 EFO61017.1 - 0.00062 19.0 0.0 0.0018 17.5 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TIP49 PF06068.13 EFO61017.1 - 0.00072 18.9 0.0 0.0013 18.0 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 EFO61017.1 - 0.0013 18.5 0.1 0.0041 16.9 0.1 1.8 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFO61017.1 - 0.002 18.4 0.1 0.022 15.0 0.1 2.4 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EFO61017.1 - 0.0041 16.9 0.0 0.0078 16.0 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 EFO61017.1 - 0.0093 15.8 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EFO61017.1 - 0.017 15.0 0.1 0.04 13.8 0.1 1.6 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.6 EFO61017.1 - 0.018 15.2 0.0 0.055 13.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain IPT PF01745.16 EFO61017.1 - 0.02 14.3 0.3 0.054 12.9 0.0 1.7 2 0 0 2 2 2 0 Isopentenyl transferase CPT PF07931.12 EFO61017.1 - 0.041 13.7 0.0 0.079 12.8 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_28 PF13521.6 EFO61017.1 - 0.051 13.8 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFO61017.1 - 0.067 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF2075 PF09848.9 EFO61017.1 - 0.078 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TsaE PF02367.17 EFO61017.1 - 0.09 12.8 0.1 0.24 11.4 0.1 1.6 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 EFO61017.1 - 0.096 12.4 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFO61017.1 - 0.11 12.6 0.1 0.65 10.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EFO61017.1 - 0.23 11.9 0.9 1.1 9.8 0.1 2.3 2 0 0 2 2 2 0 ABC transporter DUF3450 PF11932.8 EFO61017.1 - 0.35 10.1 5.5 0.53 9.5 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) LEM PF03020.15 EFO61017.1 - 0.58 9.8 4.7 0.29 10.8 1.3 2.2 2 0 0 2 2 2 0 LEM domain Ank_4 PF13637.6 EFO61019.1 - 0.00085 19.8 0.1 4.2 8.1 0.0 3.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFO61019.1 - 0.0014 19.2 1.5 2.7 8.6 0.0 4.4 4 1 1 5 5 5 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61019.1 - 0.0077 16.5 0.1 1.2 9.5 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeats (many copies) YmgB PF10798.8 EFO61019.1 - 0.13 12.1 0.2 0.33 10.8 0.2 1.6 1 0 0 1 1 1 0 Biofilm development protein YmgB/AriR Ank_3 PF13606.6 EFO61019.1 - 0.19 12.4 4.6 5.2 8.0 0.0 4.6 4 0 0 4 4 4 0 Ankyrin repeat Maf1 PF09174.10 EFO61019.1 - 0.85 9.8 8.5 0.044 13.9 1.3 2.7 3 0 0 3 3 3 0 Maf1 regulator Ank PF00023.30 EFO61019.1 - 2.2 8.9 13.6 0.62 10.6 0.0 4.9 4 1 0 4 4 4 0 Ankyrin repeat HTH_23 PF13384.6 EFO61020.1 - 0.035 13.9 0.0 0.1 12.4 0.0 1.9 1 0 0 1 1 1 0 Homeodomain-like domain Terminase_5 PF06056.12 EFO61020.1 - 0.041 13.8 0.1 0.16 11.8 0.1 1.9 1 1 1 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) Myb_DNA-bind_6 PF13921.6 EFO61020.1 - 0.1 12.8 0.1 0.43 10.9 0.0 1.9 2 0 0 2 2 2 0 Myb-like DNA-binding domain Ribosomal_L37ae PF01780.19 EFO61023.1 - 1.4e-36 124.4 7.0 1.6e-36 124.3 7.0 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 EFO61023.1 - 0.00055 19.9 4.5 0.00098 19.1 4.5 1.5 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zf-H2C2_2 PF13465.6 EFO61023.1 - 0.0098 16.3 3.5 0.087 13.3 0.3 2.4 2 0 0 2 2 2 1 Zinc-finger double domain Zn_Tnp_IS91 PF14319.6 EFO61023.1 - 0.018 15.1 1.3 0.021 14.8 1.3 1.2 1 0 0 1 1 1 0 Transposase zinc-binding domain zf-RING_13 PF17977.1 EFO61023.1 - 0.021 15.0 1.9 0.027 14.6 1.9 1.2 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Sgf11 PF08209.11 EFO61023.1 - 0.031 13.8 0.4 0.81 9.3 0.0 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) NUFIP1 PF10453.9 EFO61024.1 - 1e-05 25.3 0.9 1.5e-05 24.7 0.9 1.3 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) DUF3450 PF11932.8 EFO61028.1 - 0.016 14.5 0.7 0.016 14.5 0.7 3.9 2 1 0 3 3 3 0 Protein of unknown function (DUF3450) GAS PF13851.6 EFO61028.1 - 0.085 12.2 37.1 0.19 11.1 19.2 3.5 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding MukF_M PF17192.4 EFO61028.1 - 0.2 11.4 16.6 0.074 12.8 12.5 2.4 2 0 0 2 2 2 0 MukF middle domain DUF3153 PF11353.8 EFO61028.1 - 0.89 9.1 10.2 0.59 9.7 1.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3153) HALZ PF02183.18 EFO61028.1 - 4 7.8 13.7 3.5 7.9 0.1 5.2 4 1 0 4 4 4 0 Homeobox associated leucine zipper TPR_MLP1_2 PF07926.12 EFO61028.1 - 4.7 7.3 36.8 0.56 10.3 4.2 4.2 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein YabA PF06156.13 EFO61028.1 - 5 7.8 32.9 0.53 11.0 2.6 4.6 2 1 2 4 4 4 0 Initiation control protein YabA FlgM PF04316.13 EFO61028.1 - 6.1 7.3 6.4 4 7.9 1.3 3.0 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM FAS_I_H PF18314.1 EFO61028.1 - 6.4 6.4 11.7 3.8 7.1 3.7 2.8 1 1 1 2 2 2 0 Fatty acid synthase type I helical domain HIP1_clath_bdg PF16515.5 EFO61028.1 - 7.5 7.2 34.5 0.28 11.8 0.5 4.8 2 1 1 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Peptidase_S46 PF10459.9 EFO61028.1 - 9 4.8 17.9 0.42 9.2 4.6 2.3 1 1 1 2 2 2 0 Peptidase S46 DUF2441 PF10386.9 EFO61028.1 - 9.3 6.2 9.4 0.62 10.1 1.7 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2441) Rad51 PF08423.11 EFO61031.1 - 2.9e-05 23.5 0.0 0.0088 15.3 0.0 3.0 3 0 0 3 3 3 1 Rad51 AAA_25 PF13481.6 EFO61031.1 - 0.00057 19.5 0.0 0.0097 15.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EFO61031.1 - 0.029 14.2 0.0 0.053 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EFO61031.1 - 0.029 13.7 0.0 0.081 12.3 0.0 1.7 2 0 0 2 2 2 0 KaiC DUF424 PF04242.13 EFO61031.1 - 0.058 13.7 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF424) AAA_29 PF13555.6 EFO61031.1 - 0.11 12.2 0.0 7.8 6.3 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain SPC25 PF06703.11 EFO61033.1 - 0.0024 17.7 0.0 0.0044 16.8 0.0 1.4 1 1 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) Ribosomal_L10 PF00466.20 EFO61034.1 - 4.8e-25 87.6 0.2 7.1e-25 87.1 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 EFO61034.1 - 2.9e-21 75.3 0.0 5e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P 7TMR-HDED PF07697.11 EFO61034.1 - 0.013 15.7 0.1 1.3 9.1 0.3 2.3 2 1 0 2 2 2 0 7TM-HD extracellular DIOX_N PF14226.6 EFO61034.1 - 0.023 15.4 0.0 0.037 14.8 0.0 1.3 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal DUF936 PF06075.12 EFO61035.1 - 5.2 5.9 29.5 9.8 5.0 29.5 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Ank_2 PF12796.7 EFO61036.1 - 1e-96 317.7 10.7 1.3e-16 60.9 0.0 8.5 1 1 6 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61036.1 - 1.7e-64 213.4 2.4 6.4e-10 39.4 0.0 11.1 9 2 1 10 10 10 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61036.1 - 7.5e-56 179.5 7.5 0.0016 18.8 0.0 15.6 15 1 1 16 16 16 13 Ankyrin repeat Ank PF00023.30 EFO61036.1 - 1.5e-54 180.1 10.3 6.7e-05 23.2 0.0 14.7 13 1 1 14 14 14 12 Ankyrin repeat Ank_5 PF13857.6 EFO61036.1 - 9.2e-54 178.8 17.1 6.9e-05 23.0 0.1 13.3 2 2 13 15 15 15 15 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO61036.1 - 1.2e-33 116.6 0.0 2.8e-32 112.1 0.0 2.4 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61036.1 - 1.2e-21 77.2 0.0 2.3e-21 76.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase AAA_13 PF13166.6 EFO61036.1 - 0.0017 17.1 0.4 0.0048 15.6 0.4 1.5 1 1 0 1 1 1 1 AAA domain ATG16 PF08614.11 EFO61036.1 - 0.002 18.4 1.3 0.0049 17.1 1.3 1.7 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) SpoU_sub_bind PF08032.12 EFO61036.1 - 0.026 14.8 1.0 18 5.7 0.1 5.1 3 1 1 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding HAP1_N PF04849.13 EFO61036.1 - 0.11 11.6 5.1 0.15 11.2 1.7 2.7 3 1 0 3 3 3 0 HAP1 N-terminal conserved region SIP PF04954.13 EFO61036.1 - 2.6 8.6 6.0 0.34 11.4 0.2 2.5 3 0 0 3 3 3 0 Siderophore-interacting protein Fez1 PF06818.15 EFO61036.1 - 4.3 7.8 5.0 17 5.8 4.4 2.3 2 1 0 2 2 1 0 Fez1 FtsJ PF01728.19 EFO61037.1 - 2.6e-22 79.8 0.0 3.6e-22 79.3 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 EFO61037.1 - 0.036 13.4 0.0 0.067 12.5 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain DUF5524 PF17662.1 EFO61037.1 - 0.24 10.8 0.0 0.36 10.2 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5524) Acetyltransf_11 PF13720.6 EFO61038.1 - 2.1 8.8 4.7 0.75 10.3 0.1 2.5 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 SlyX PF04102.12 EFO61040.1 - 0.00036 21.1 2.3 0.00036 21.1 2.3 11.6 11 4 2 13 13 13 3 SlyX UPF0242 PF06785.11 EFO61040.1 - 0.0036 17.4 56.1 0.033 14.3 12.5 7.1 5 2 2 7 7 7 4 Uncharacterised protein family (UPF0242) N-terminus TMF_DNA_bd PF12329.8 EFO61040.1 - 0.0048 16.9 11.5 0.0048 16.9 11.5 10.1 11 0 0 11 11 11 2 TATA element modulatory factor 1 DNA binding KASH_CCD PF14662.6 EFO61040.1 - 0.019 14.8 0.2 0.019 14.8 0.2 6.8 7 2 1 8 8 8 0 Coiled-coil region of CCDC155 or KASH Sin3_corepress PF08295.12 EFO61040.1 - 0.036 14.2 0.7 0.24 11.5 0.7 2.5 1 0 0 1 1 1 0 Sin3 family co-repressor XLF PF09302.11 EFO61040.1 - 0.072 13.3 32.5 0.15 12.3 2.2 5.9 4 0 0 4 4 4 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component Pox_A_type_inc PF04508.12 EFO61040.1 - 0.093 12.6 0.0 0.093 12.6 0.0 6.0 7 0 0 7 7 7 0 Viral A-type inclusion protein repeat FAM76 PF16046.5 EFO61040.1 - 0.21 10.9 53.0 6.2 6.1 0.0 7.1 4 1 3 7 7 7 0 FAM76 protein ATG16 PF08614.11 EFO61040.1 - 4.4 7.5 82.6 0.098 12.9 0.2 8.2 7 3 0 7 7 7 0 Autophagy protein 16 (ATG16) JIP_LZII PF16471.5 EFO61040.1 - 4.7 7.5 26.8 3.2 8.0 0.2 6.6 4 1 0 5 5 5 0 JNK-interacting protein leucine zipper II Fez1 PF06818.15 EFO61040.1 - 5.7 7.3 62.4 0.1 13.0 14.0 6.8 4 2 2 6 6 6 0 Fez1 Ras PF00071.22 EFO61041.1 - 7.2e-33 113.5 0.1 8.3e-33 113.3 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFO61041.1 - 9.1e-16 58.2 0.0 1.2e-15 57.8 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFO61041.1 - 1.9e-10 40.5 0.0 2.5e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFO61041.1 - 0.0018 18.3 0.0 0.0026 17.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase TB2_DP1_HVA22 PF03134.19 EFO61042.1 - 6.8e-13 48.4 1.4 7.9e-13 48.1 0.4 1.6 2 0 0 2 2 2 1 TB2/DP1, HVA22 family Phage_gp53 PF11246.8 EFO61042.1 - 0.047 13.4 0.0 0.057 13.1 0.0 1.1 1 0 0 1 1 1 0 Base plate wedge protein 53 tRNA-synt_2d PF01409.20 EFO61044.1 - 5.5e-80 268.4 0.0 1.1e-79 267.4 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) PheRS_DBD1 PF18552.1 EFO61044.1 - 8.4e-05 22.3 0.0 0.00028 20.6 0.0 1.9 1 0 0 1 1 1 1 PheRS DNA binding domain 1 PheRS_DBD3 PF18553.1 EFO61044.1 - 0.00097 19.4 0.0 0.0038 17.5 0.0 2.1 1 0 0 1 1 1 1 PheRS DNA binding domain 3 tRNA-synt_2 PF00152.20 EFO61044.1 - 0.0016 17.6 2.7 0.078 12.0 0.2 3.4 3 1 1 4 4 4 1 tRNA synthetases class II (D, K and N) HTH_20 PF12840.7 EFO61044.1 - 0.11 12.6 0.2 0.49 10.5 0.1 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain BPL_N PF09825.9 EFO61045.1 - 0.003 16.7 1.9 0.0049 16.0 1.9 1.3 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal DUF521 PF04412.13 EFO61045.1 - 0.039 12.7 0.7 0.062 12.0 0.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF521) Rx_N PF18052.1 EFO61045.1 - 0.2 11.9 4.9 1.1 9.5 0.2 3.1 3 0 0 3 3 3 0 Rx N-terminal domain LidA_Long_CC PF18641.1 EFO61045.1 - 0.27 11.3 6.2 0.13 12.3 0.5 3.0 3 0 0 3 3 3 0 LidA long coiled-coil domain FliT PF05400.13 EFO61045.1 - 0.93 10.3 14.9 1.4 9.8 1.6 3.5 4 0 0 4 4 4 0 Flagellar protein FliT DUF724 PF05266.14 EFO61045.1 - 6.1 6.6 9.7 1.2 8.9 1.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF724) LSM PF01423.22 EFO61046.1 - 9.5e-12 44.4 0.0 1.1e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 LSM domain LSM14 PF12701.7 EFO61046.1 - 0.0043 17.1 0.0 0.013 15.6 0.0 1.7 1 1 0 1 1 1 1 Scd6-like Sm domain DUF2642 PF10842.8 EFO61046.1 - 0.063 13.1 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2642) SM-ATX PF14438.6 EFO61046.1 - 0.11 12.7 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain CENP-T_C PF15511.6 EFO61047.1 - 1.2e-09 38.2 0.1 1.5e-09 38.0 0.1 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EFO61047.1 - 1.9e-05 25.1 0.2 2.4e-05 24.7 0.2 1.2 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EFO61047.1 - 6e-05 23.1 0.0 7.3e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit TAF PF02969.17 EFO61047.1 - 0.00014 21.9 0.0 0.00022 21.3 0.0 1.3 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EFO61047.1 - 0.00032 20.9 0.0 0.00045 20.5 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EFO61047.1 - 0.00059 20.2 0.1 0.00089 19.6 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein Bromo_TP PF07524.13 EFO61047.1 - 0.14 12.1 0.0 0.24 11.4 0.0 1.4 1 1 0 1 1 1 0 Bromodomain associated VSP PF03302.13 EFO61049.1 - 4.2e-25 88.4 155.9 1.8e-09 36.9 30.0 6.3 1 1 5 6 6 6 5 Giardia variant-specific surface protein CPSF_A PF03178.15 EFO61051.1 - 5.2e-09 35.9 0.0 0.00066 19.1 0.0 2.1 2 0 0 2 2 2 2 CPSF A subunit region Myotub-related PF06602.14 EFO61052.1 - 0.092 11.7 0.0 0.18 10.7 0.0 1.4 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain AstE_AspA PF04952.14 EFO61053.1 - 1.5e-05 24.2 0.0 3.6e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Peptidase_M14 PF00246.24 EFO61053.1 - 0.0048 16.7 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 Zinc carboxypeptidase Vps62 PF06101.11 EFO61054.1 - 1.8e-13 49.7 0.0 5.8e-06 24.9 0.0 3.2 3 0 0 3 3 3 3 Vacuolar protein sorting-associated protein 62 Tubulin PF00091.25 EFO61055.1 - 6.7e-53 179.8 0.0 7.7e-53 179.6 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 EFO61055.1 - 6.6e-05 22.7 0.0 9.8e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Nitroreductase PF00881.24 EFO61056.1 - 1.8e-11 44.4 0.3 1.7e-07 31.4 0.1 2.1 1 1 1 2 2 2 2 Nitroreductase family TM1586_NiRdase PF14512.6 EFO61056.1 - 0.0062 16.1 0.1 0.071 12.7 0.1 2.2 1 1 0 1 1 1 1 Putative TM nitroreductase UPF0160 PF03690.13 EFO61057.1 - 2.4e-87 293.6 0.0 2.8e-87 293.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) LSM PF01423.22 EFO61058.1 - 5.7e-14 51.6 0.0 7.3e-14 51.2 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFO61058.1 - 0.055 13.6 0.1 0.14 12.3 0.0 1.7 2 0 0 2 2 2 0 Ataxin 2 SM domain YqhG PF11079.8 EFO61058.1 - 0.092 11.7 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein YqhG of unknown function SNAP PF14938.6 EFO61059.1 - 6.9e-16 58.5 9.6 1.1e-15 57.9 9.6 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF1160 PF06648.11 EFO61059.1 - 0.06 13.4 0.2 0.11 12.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1160) TraB PF01963.17 EFO61059.1 - 2.5 7.9 6.2 56 3.5 6.1 2.4 1 1 0 1 1 1 0 TraB family Ank_2 PF12796.7 EFO61060.1 - 2.5e-19 69.6 3.3 6.1e-09 36.3 0.1 3.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61060.1 - 5e-08 33.1 1.2 0.041 14.2 0.0 4.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61060.1 - 2.2e-07 31.3 2.5 0.16 12.6 0.2 4.0 2 2 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61060.1 - 7.5e-05 22.8 3.3 0.23 12.2 0.0 4.7 5 0 0 5 5 5 1 Ankyrin repeat Ank PF00023.30 EFO61060.1 - 0.00057 20.2 1.1 3.6 8.2 0.0 4.7 5 0 0 5 5 5 1 Ankyrin repeat Polysacc_synt_2 PF02719.15 EFO61060.1 - 0.15 11.2 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Ank_2 PF12796.7 EFO61062.1 - 4.4e-102 334.8 36.1 1.2e-09 38.6 0.1 13.7 6 2 7 14 14 14 14 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61062.1 - 3.7e-53 176.9 40.1 4.3e-05 23.7 0.0 19.3 13 5 7 20 20 20 14 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61062.1 - 5.4e-44 148.0 32.7 0.00013 22.5 0.1 16.9 12 5 9 21 21 21 15 Ankyrin repeats (many copies) Ank PF00023.30 EFO61062.1 - 3e-40 134.9 37.2 0.00069 20.0 0.0 20.2 20 1 0 20 20 20 10 Ankyrin repeat Ank_3 PF13606.6 EFO61062.1 - 3.9e-40 131.3 34.5 0.019 15.5 0.0 20.4 22 0 0 22 22 22 12 Ankyrin repeat HTH_10 PF04967.12 EFO61062.1 - 0.14 12.0 0.7 16 5.4 0.0 3.6 3 0 0 3 3 3 0 HTH DNA binding domain Ank_2 PF12796.7 EFO61063.1 - 2.1e-54 182.0 11.6 1.3e-13 51.3 0.1 5.2 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61063.1 - 2.7e-37 126.6 3.0 6.7e-06 26.6 0.1 8.4 5 3 3 8 8 8 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO61063.1 - 3.2e-31 107.0 14.2 0.00014 22.1 0.0 9.5 3 2 7 10 10 10 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61063.1 - 8.3e-31 102.6 9.4 0.041 14.4 0.0 10.4 11 0 0 11 11 11 8 Ankyrin repeat Ank PF00023.30 EFO61063.1 - 5.9e-29 99.2 9.5 0.035 14.6 0.0 10.4 11 0 0 11 11 11 8 Ankyrin repeat Pkinase PF00069.25 EFO61064.1 - 3.2e-18 66.0 0.0 6e-18 65.2 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61064.1 - 2.5e-14 53.2 0.0 3.7e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFO61064.1 - 0.00044 20.2 0.5 0.001 19.0 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family DUF2968 PF11180.8 EFO61064.1 - 0.065 12.9 0.1 0.09 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) XhlA PF10779.9 EFO61064.1 - 0.27 11.4 1.3 0.59 10.4 1.3 1.6 1 0 0 1 1 1 0 Haemolysin XhlA Ank_2 PF12796.7 EFO61065.1 - 8.7e-39 132.0 0.0 2.8e-12 47.0 0.0 3.0 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61065.1 - 6e-16 58.3 0.2 0.00045 20.5 0.0 4.3 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61065.1 - 2.1e-15 56.8 0.1 6.4e-07 29.8 0.0 4.3 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61065.1 - 5.8e-15 53.9 0.0 0.00088 19.6 0.0 5.1 4 1 1 5 5 5 3 Ankyrin repeat Ank PF00023.30 EFO61065.1 - 7.2e-13 48.4 0.2 0.0089 16.4 0.2 5.0 4 1 0 4 4 4 3 Ankyrin repeat zf-C2H2_4 PF13894.6 EFO61066.1 - 0.88 10.6 6.8 4.5 8.4 0.3 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger RVT_1 PF00078.27 EFO61067.1 - 1.4e-25 90.1 0.0 1.9e-25 89.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) VSP PF03302.13 EFO61068.1 - 3.4e-139 464.1 152.7 8.7e-124 413.4 95.1 4.5 1 1 2 4 4 4 3 Giardia variant-specific surface protein PQ-loop PF04193.14 EFO61069.1 - 1.1e-09 37.9 28.9 1e-05 25.2 6.4 3.2 3 0 0 3 3 3 2 PQ loop repeat DHHC PF01529.20 EFO61069.1 - 0.046 13.8 0.5 0.046 13.8 0.5 3.8 1 1 2 3 3 3 0 DHHC palmitoyltransferase FixQ PF05545.11 EFO61069.1 - 2.3 8.2 0.0 2.3 8.2 0.0 3.8 6 0 0 6 6 6 0 Cbb3-type cytochrome oxidase component FixQ Mo25 PF08569.11 EFO61070.1 - 3.3e-81 273.2 5.6 3.7e-81 273.0 5.6 1.0 1 0 0 1 1 1 1 Mo25-like ComC PF03047.14 EFO61070.1 - 0.24 11.2 0.5 7.9 6.4 0.0 2.6 2 0 0 2 2 2 0 COMC family CPSF_A PF03178.15 EFO61072.1 - 5.5e-07 29.2 0.0 1.4e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 CPSF A subunit region Cation_ATPase_C PF00689.21 EFO61075.1 - 4.4e-47 160.1 3.1 4.4e-47 160.1 3.1 3.1 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFO61075.1 - 4.8e-46 156.6 5.3 9.1e-46 155.7 0.3 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_N PF00690.26 EFO61075.1 - 7.7e-20 70.4 0.0 1.8e-19 69.2 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 EFO61075.1 - 7.7e-15 55.7 0.0 4.6e-05 23.8 0.0 3.7 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFO61075.1 - 5.5e-11 42.4 0.0 1.2e-10 41.3 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFO61075.1 - 0.00035 20.4 4.4 0.00041 20.2 1.3 2.4 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Cation_efflux PF01545.21 EFO61075.1 - 0.45 10.2 9.4 0.17 11.6 0.4 2.7 2 0 0 2 2 2 0 Cation efflux family Septin PF00735.18 EFO61078.1 - 1.3e-05 24.6 0.0 4.9e-05 22.8 0.0 1.8 1 1 0 1 1 1 1 Septin RsgA_GTPase PF03193.16 EFO61078.1 - 5.4e-05 23.2 0.3 0.00078 19.4 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EFO61078.1 - 0.00045 20.3 0.0 0.0011 19.0 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 EFO61078.1 - 0.0013 18.5 0.0 0.0024 17.6 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFO61078.1 - 0.0039 17.6 0.0 0.0075 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 EFO61078.1 - 0.0053 16.6 0.0 0.0086 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EFO61078.1 - 0.0086 16.4 0.1 0.033 14.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EFO61078.1 - 0.0094 15.7 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EFO61078.1 - 0.02 15.4 0.0 0.041 14.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter FtsK_SpoIIIE PF01580.18 EFO61078.1 - 0.021 14.2 0.0 5 6.4 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family Roc PF08477.13 EFO61078.1 - 0.027 14.7 0.0 0.047 13.9 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 EFO61078.1 - 0.043 13.1 0.1 1.3 8.3 0.0 2.3 2 0 0 2 2 2 0 AIG1 family G-alpha PF00503.20 EFO61078.1 - 0.05 12.8 0.0 0.1 11.8 0.0 1.4 2 0 0 2 2 2 0 G-protein alpha subunit AAA_7 PF12775.7 EFO61078.1 - 0.058 12.9 0.0 0.13 11.8 0.0 1.5 1 1 1 2 2 2 0 P-loop containing dynein motor region IIGP PF05049.13 EFO61078.1 - 0.059 12.4 0.0 0.083 11.9 0.0 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) HCV_NS5a PF01506.19 EFO61078.1 - 0.065 13.1 0.3 1.8 8.6 0.0 2.5 2 0 0 2 2 2 0 Hepatitis C virus non-structural 5a protein membrane anchor Sigma54_activat PF00158.26 EFO61078.1 - 0.085 12.5 0.0 0.19 11.4 0.0 1.5 2 0 0 2 2 2 0 Sigma-54 interaction domain TniB PF05621.11 EFO61078.1 - 0.1 12.0 0.0 0.35 10.3 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein Ras PF00071.22 EFO61078.1 - 0.1 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Ras family EGF_Tenascin PF18720.1 EFO61079.1 - 0.026 14.6 7.4 0.026 14.6 7.4 5.0 4 1 0 4 4 4 0 Tenascin EGF domain Iwr1 PF08574.10 EFO61080.1 - 0.0036 18.3 1.2 0.0055 17.7 1.2 1.3 1 0 0 1 1 1 1 Transcription factor Iwr1 Epsilon_antitox PF08998.11 EFO61080.1 - 0.17 12.1 0.0 0.24 11.7 0.0 1.2 1 0 0 1 1 1 0 Bacterial epsilon antitoxin RhoGAP PF00620.27 EFO61082.1 - 5.8e-12 45.7 0.0 7.9e-08 32.3 0.0 2.5 3 0 0 3 3 3 2 RhoGAP domain DUF4075 PF13294.6 EFO61082.1 - 0.12 12.5 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4075) TRAPP PF04051.16 EFO61085.1 - 2.9e-17 62.7 0.0 4.2e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Nop16 PF09420.10 EFO61086.1 - 5e-08 33.2 1.0 1e-07 32.2 0.1 1.9 2 1 0 2 2 2 1 Ribosome biogenesis protein Nop16 Ribosomal_L15e PF00827.17 EFO61087.1 - 6.3e-89 296.8 4.7 7.3e-89 296.6 4.7 1.0 1 0 0 1 1 1 1 Ribosomal L15 eIF-6 PF01912.18 EFO61088.1 - 1.5e-75 252.9 0.2 3.6e-75 251.7 0.1 1.6 1 1 1 2 2 2 1 eIF-6 family Ribosomal_S3_C PF00189.20 EFO61089.1 - 2.8e-22 79.0 2.7 4.8e-22 78.3 2.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain VSP PF03302.13 EFO61090.1 - 6e-26 91.2 50.6 2.2e-19 69.6 8.8 3.0 1 1 2 3 3 3 3 Giardia variant-specific surface protein BmKX PF09132.10 EFO61090.1 - 4.7e-09 36.1 14.7 4.7e-09 36.1 14.7 3.4 3 1 0 3 3 3 2 BmKX Furin-like_2 PF15913.5 EFO61090.1 - 4.6e-05 23.5 21.4 0.0071 16.5 2.9 3.0 1 1 2 3 3 3 3 Furin-like repeat, cysteine-rich Ank_2 PF12796.7 EFO61092.1 - 2.4e-109 358.1 10.8 1.4e-20 73.7 0.4 5.3 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61092.1 - 1.1e-50 169.4 5.7 3.1e-09 37.2 0.1 8.4 8 1 0 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO61092.1 - 9.7e-44 146.0 2.1 7.6e-05 23.0 0.0 9.5 9 1 1 10 10 10 8 Ankyrin repeat Ank_5 PF13857.6 EFO61092.1 - 1.6e-40 136.6 12.0 8.6e-07 29.1 0.0 8.8 1 1 8 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61092.1 - 3.3e-37 122.3 2.9 0.00075 19.8 0.0 10.1 10 0 0 10 10 10 7 Ankyrin repeat Pkinase PF00069.25 EFO61092.1 - 1.9e-05 24.2 0.0 0.00011 21.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61092.1 - 3.9e-05 23.1 0.0 5.7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase T3SSipB PF16535.5 EFO61092.1 - 0.48 10.9 4.2 0.77 10.2 4.2 1.2 1 0 0 1 1 1 0 Type III cell invasion protein SipB RVT_1 PF00078.27 EFO61094.1 - 1.5e-28 99.8 0.0 2.2e-28 99.3 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ank_2 PF12796.7 EFO61095.1 - 4.4e-154 501.5 70.3 2.2e-14 53.8 0.1 15.9 2 2 15 18 18 18 18 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61095.1 - 3.2e-89 292.2 46.4 6.8e-06 26.5 0.6 23.7 8 7 19 28 28 28 27 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO61095.1 - 8.5e-79 258.6 59.1 1.8e-06 28.1 0.0 26.8 5 5 22 28 28 28 24 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61095.1 - 7.7e-77 244.0 44.0 0.0044 17.4 0.0 31.0 31 2 2 33 33 33 19 Ankyrin repeat Ank PF00023.30 EFO61095.1 - 2.5e-72 236.4 57.4 0.0098 16.3 0.0 29.4 24 6 5 29 29 29 21 Ankyrin repeat CdAMP_rec PF06153.11 EFO61095.1 - 0.00023 21.3 0.7 3.4 7.9 0.0 4.8 4 1 1 5 5 5 2 Cyclic-di-AMP receptor HTH_16 PF12645.7 EFO61095.1 - 0.63 10.1 3.8 56 3.9 0.1 4.4 4 0 0 4 4 4 0 Helix-turn-helix domain IQ PF00612.27 EFO61097.1 - 0.0079 15.9 5.2 0.21 11.5 0.8 2.7 2 0 0 2 2 2 2 IQ calmodulin-binding motif WRKY PF03106.15 EFO61098.1 - 1.1e-28 99.3 11.3 4.4e-17 62.1 2.2 2.7 3 0 0 3 3 3 2 WRKY DNA -binding domain FLYWCH PF04500.16 EFO61098.1 - 0.003 17.6 1.9 1.7 8.8 0.3 2.7 2 0 0 2 2 2 2 FLYWCH zinc finger domain NIF3 PF01784.18 EFO61100.1 - 4.6e-48 164.0 0.0 6.1e-48 163.6 0.0 1.1 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) HTH_Tnp_1 PF01527.20 EFO61100.1 - 0.039 14.3 0.0 0.079 13.3 0.0 1.4 1 0 0 1 1 1 0 Transposase Ank_2 PF12796.7 EFO61101.1 - 8.9e-131 426.8 28.2 7.8e-19 68.1 0.4 11.4 1 1 10 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61101.1 - 1.6e-79 261.3 18.3 8.2e-09 35.8 0.1 15.5 11 6 6 17 17 17 14 Ankyrin repeats (many copies) Ank PF00023.30 EFO61101.1 - 3.3e-75 245.5 28.2 5.2e-05 23.5 0.0 21.4 22 0 0 22 22 22 18 Ankyrin repeat Ank_5 PF13857.6 EFO61101.1 - 5.9e-73 240.0 27.3 2.3e-06 27.8 0.1 19.3 4 4 14 19 19 19 18 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61101.1 - 4.6e-68 217.1 24.3 0.0012 19.2 0.0 21.7 21 2 2 23 23 23 16 Ankyrin repeat 3HCDH_RFF PF18321.1 EFO61101.1 - 2.4 8.7 9.5 23 5.6 0.0 6.1 6 1 0 6 6 6 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain VSP PF03302.13 EFO61102.1 - 1.7e-70 237.9 135.6 3.1e-51 174.5 53.2 4.0 1 1 3 4 4 4 4 Giardia variant-specific surface protein BmKX PF09132.10 EFO61102.1 - 1.3e-31 108.3 34.2 6.9e-17 61.1 13.1 11.0 12 0 0 12 12 12 3 BmKX Furin-like_2 PF15913.5 EFO61102.1 - 3.2e-05 24.0 15.9 3.2e-05 24.0 15.9 7.7 1 1 5 6 6 6 3 Furin-like repeat, cysteine-rich Ank_2 PF12796.7 EFO61103.1 - 2.9e-43 146.4 22.8 1.2e-10 41.8 0.0 6.1 2 2 6 8 8 8 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61103.1 - 2.1e-27 94.8 17.1 0.0019 18.4 0.1 10.0 5 3 5 10 10 10 9 Ankyrin repeats (many copies) Ank PF00023.30 EFO61103.1 - 1.1e-26 92.0 10.2 0.014 15.9 0.0 10.3 11 0 0 11 11 11 8 Ankyrin repeat Ank_3 PF13606.6 EFO61103.1 - 5.5e-25 84.7 10.9 0.036 14.6 0.0 10.8 11 0 0 11 11 11 7 Ankyrin repeat Ank_4 PF13637.6 EFO61103.1 - 1.1e-19 70.4 11.0 0.0048 17.5 0.4 8.7 7 2 1 8 8 8 6 Ankyrin repeats (many copies) Cyclin_N PF00134.23 EFO61103.1 - 0.38 10.5 4.0 8.5 6.1 0.6 3.8 3 2 1 4 4 4 0 Cyclin, N-terminal domain PAP1 PF08601.10 EFO61103.1 - 4.6 6.9 13.3 6.9 6.3 13.3 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 HTH_13 PF11972.8 EFO61104.1 - 0.14 12.2 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 HTH DNA binding domain Mic1 PF07035.12 EFO61106.1 - 0.051 13.3 3.3 0.11 12.1 0.4 3.0 4 0 0 4 4 4 0 Colon cancer-associated protein Mic1-like MnmE_helical PF12631.7 EFO61106.1 - 1.6 8.9 9.7 4.7 7.3 0.2 3.1 3 0 0 3 3 3 0 MnmE helical domain Clathrin PF00637.20 EFO61106.1 - 3.2 7.6 13.7 13 5.6 0.4 4.7 5 0 0 5 5 5 0 Region in Clathrin and VPS Ank_2 PF12796.7 EFO61107.1 - 3.4e-102 335.2 29.3 1.7e-15 57.4 0.0 10.0 2 1 10 12 12 12 11 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61107.1 - 1.5e-46 155.9 8.2 6.3e-05 23.2 0.0 12.1 4 4 7 12 12 12 10 Ankyrin repeats (many copies) Ank PF00023.30 EFO61107.1 - 1.8e-45 151.4 14.5 0.00079 19.8 0.0 15.6 14 1 1 15 15 15 13 Ankyrin repeat Ank_4 PF13637.6 EFO61107.1 - 7.8e-43 144.3 12.0 5.6e-06 26.8 0.0 11.9 9 3 3 12 12 12 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61107.1 - 1.5e-41 135.6 17.4 0.19 12.4 0.0 16.4 16 0 0 16 16 16 11 Ankyrin repeat Pkinase PF00069.25 EFO61107.1 - 0.029 13.7 0.1 1.2 8.5 0.1 2.6 2 1 0 2 2 2 0 Protein kinase domain FKBP_C PF00254.28 EFO61108.1 - 4.9e-31 106.9 0.0 1.5e-30 105.3 0.0 1.9 3 0 0 3 3 3 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.17 EFO61108.1 - 2.4e-05 24.1 3.4 0.015 15.4 0.5 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFO61108.1 - 0.003 17.8 2.2 1.9 8.8 0.1 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFO61108.1 - 0.0065 16.1 0.5 0.013 15.2 0.5 1.5 1 0 0 1 1 1 1 TPR repeat DUF1955 PF09205.10 EFO61108.1 - 0.026 14.3 0.4 0.056 13.2 0.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1955) TPR_1 PF00515.28 EFO61108.1 - 0.077 12.9 3.2 0.21 11.5 0.5 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF5318 PF17249.2 EFO61109.1 - 0.00017 21.4 0.5 0.0014 18.4 0.1 2.8 2 1 1 3 3 3 1 Family of unknown function (DUF5318) DUF3800 PF12686.7 EFO61109.1 - 0.0014 19.2 0.0 20 5.8 0.0 6.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3800) AAA_13 PF13166.6 EFO61109.1 - 0.077 11.6 142.8 0.011 14.4 6.1 8.3 2 1 7 10 10 10 0 AAA domain Cyt-b5 PF00173.28 EFO61111.1 - 3.4e-19 68.8 0.0 4.7e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain EntA_Immun PF08951.10 EFO61113.1 - 0.018 15.4 3.4 0.085 13.2 0.7 3.0 3 0 0 3 3 3 0 Enterocin A Immunity ComR_TPR PF18710.1 EFO61113.1 - 0.11 12.0 3.2 0.087 12.4 0.6 2.1 2 0 0 2 2 2 0 ComR tetratricopeptide VSP PF03302.13 EFO61114.1 - 1.9e-37 129.1 184.9 3.5e-30 105.1 72.4 7.2 1 1 5 6 6 6 5 Giardia variant-specific surface protein Profilin PF00235.19 EFO61114.1 - 9.7 6.5 8.8 0.23 11.7 0.4 2.7 3 0 0 3 3 3 0 Profilin VSP PF03302.13 EFO61115.1 - 1.8e-116 389.3 213.0 1.1e-56 192.5 67.2 5.1 1 1 4 5 5 5 4 Giardia variant-specific surface protein PucR PF07905.11 EFO61116.1 - 0.049 13.9 0.0 0.096 13.0 0.0 1.4 1 0 0 1 1 1 0 Purine catabolism regulatory protein-like family IGR PF09597.10 EFO61116.1 - 0.11 12.6 0.1 0.66 10.1 0.0 2.1 2 0 0 2 2 2 0 IGR protein motif DUF927 PF06048.11 EFO61117.1 - 0.041 13.4 0.0 0.086 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF927) VSP PF03302.13 EFO61118.1 - 1e-33 116.8 104.7 5.9e-20 71.5 43.3 4.3 1 1 3 4 4 4 4 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO61118.1 - 0.59 10.3 93.0 0.72 10.0 17.0 8.5 1 1 7 9 9 9 0 Furin-like repeat, cysteine-rich VSP PF03302.13 EFO61119.1 - 2.4e-36 125.5 190.3 3.1e-27 95.5 79.0 6.2 1 1 2 3 3 3 3 Giardia variant-specific surface protein LRR_4 PF12799.7 EFO61120.1 - 1.1e-15 57.5 9.2 4e-08 33.4 1.5 3.7 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFO61120.1 - 8.7e-15 54.6 0.0 1.5e-08 34.3 0.1 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 EFO61120.1 - 1.8e-08 34.0 8.8 0.0041 16.8 3.8 4.1 2 1 2 4 4 4 3 Leucine rich repeat LRR_6 PF13516.6 EFO61120.1 - 0.66 10.2 2.9 35 4.8 0.3 3.2 2 0 0 2 2 2 0 Leucine Rich repeat AhpC-TSA PF00578.21 EFO61123.1 - 5.6e-29 100.6 0.0 7.3e-29 100.2 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFO61123.1 - 4e-13 49.3 0.0 5.4e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EFO61123.1 - 1.7e-08 34.2 0.1 3.6e-08 33.1 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin DUF563 PF04577.14 EFO61123.1 - 0.15 12.2 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF563) TLD PF07534.16 EFO61124.1 - 1.4e-10 41.6 1.5 2.5e-10 40.7 0.1 2.2 2 0 0 2 2 2 1 TLD UCH PF00443.29 EFO61125.1 - 3.9e-33 115.0 0.5 7.2e-33 114.2 0.5 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFO61125.1 - 1.5e-12 47.8 0.2 1.5e-12 47.8 0.2 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Rad21_Rec8 PF04824.16 EFO61125.1 - 0.14 11.5 0.2 0.48 9.7 0.2 1.9 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein CNDH2_N PF06278.11 EFO61126.1 - 7e-12 45.5 0.0 1.9e-11 44.2 0.0 1.7 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal CNDH2_C PF16858.5 EFO61126.1 - 4.4e-05 23.5 0.0 6.3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term DTW PF03942.15 EFO61127.1 - 2.6e-12 46.9 0.1 5e-12 45.9 0.1 1.4 1 0 0 1 1 1 1 DTW domain TF_Zn_Ribbon PF08271.12 EFO61127.1 - 6 6.5 8.0 3.9 7.1 0.1 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding Flavodoxin_1 PF00258.25 EFO61128.1 - 5.2e-20 72.1 0.0 9.1e-20 71.3 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 EFO61128.1 - 1.6e-18 67.1 0.0 4.7e-18 65.6 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain ABC2_membrane PF01061.24 EFO61130.1 - 6.6e-35 120.4 35.0 6.6e-35 120.4 35.0 2.2 3 0 0 3 3 3 1 ABC-2 type transporter ABC_tran PF00005.27 EFO61130.1 - 1e-24 87.6 0.2 2.7e-24 86.2 0.0 1.8 2 0 0 2 2 2 1 ABC transporter ABC2_membrane_3 PF12698.7 EFO61130.1 - 3.3e-05 23.2 25.1 3.3e-05 23.2 25.1 2.2 1 1 1 2 2 2 1 ABC-2 family transporter protein AAA_16 PF13191.6 EFO61130.1 - 0.00027 21.4 0.0 0.00047 20.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFO61130.1 - 0.0014 18.5 0.0 0.004 17.1 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase SMC_N PF02463.19 EFO61130.1 - 0.0063 16.0 0.3 0.44 9.9 0.0 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFO61130.1 - 0.0069 16.2 0.1 0.053 13.3 0.2 2.2 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EFO61130.1 - 0.0083 16.4 0.1 0.046 14.0 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFO61130.1 - 0.017 15.4 0.1 0.03 14.6 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EFO61130.1 - 0.017 15.5 0.8 0.27 11.7 0.3 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EFO61130.1 - 0.018 14.7 0.4 0.058 13.1 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EFO61130.1 - 0.023 14.8 0.0 0.044 13.9 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 EFO61130.1 - 0.033 14.7 0.0 0.065 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EFO61130.1 - 0.038 14.5 0.1 0.098 13.1 0.1 1.6 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 EFO61130.1 - 0.045 14.0 0.1 0.34 11.2 0.1 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SRPRB PF09439.10 EFO61130.1 - 0.086 12.3 0.1 0.39 10.1 0.0 2.0 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Zeta_toxin PF06414.12 EFO61130.1 - 0.1 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.22 EFO61130.1 - 0.14 12.6 0.0 0.34 11.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_35 PF14516.6 EFO61130.1 - 0.19 10.6 0.0 2.3 7.0 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain CAF1C_H4-bd PF12265.8 EFO61132.1 - 1.9e-14 53.6 1.3 2.4e-14 53.4 0.1 1.9 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EFO61132.1 - 5.9e-08 33.3 6.7 0.016 16.1 0.0 5.3 6 0 0 6 6 6 2 WD domain, G-beta repeat HPS3_N PF14761.6 EFO61132.1 - 0.061 12.9 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 Gp45_2 PF17470.2 EFO61133.1 - 0.13 12.2 0.0 0.39 10.7 0.0 1.7 2 0 0 2 2 2 0 Phage gene product 45.2 Myb_DNA-bind_7 PF15963.5 EFO61135.1 - 0.0045 16.9 0.5 0.011 15.6 0.5 1.6 1 0 0 1 1 1 1 Myb DNA-binding like DUF4754 PF15946.5 EFO61135.1 - 0.16 12.2 0.1 0.39 11.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4754) Myb_DNA-binding PF00249.31 EFO61135.1 - 0.18 12.0 0.0 0.41 10.9 0.0 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain Ribosomal_L36e PF01158.18 EFO61137.1 - 1.8e-22 79.4 2.9 2e-22 79.2 2.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L36e zf-C2HC_2 PF13913.6 EFO61138.1 - 1.4e-09 37.6 1.3 3.9e-09 36.2 0.5 2.0 2 0 0 2 2 2 1 zinc-finger of a C2HC-type DUF2318 PF10080.9 EFO61138.1 - 0.0053 16.9 0.0 0.0086 16.2 0.0 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2318) zf-CHCC PF10276.9 EFO61138.1 - 0.083 13.0 0.6 0.17 12.0 0.6 1.5 1 0 0 1 1 1 0 Zinc-finger domain DUF2427 PF10348.9 EFO61139.1 - 0.071 12.9 1.6 0.11 12.3 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2427) Annexin PF00191.20 EFO61140.1 - 1.1e-11 44.6 0.4 0.00014 21.8 0.0 4.0 5 0 0 5 5 5 3 Annexin Ank_2 PF12796.7 EFO61143.1 - 4.4e-59 197.0 0.0 8.9e-15 55.1 0.0 5.4 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 EFO61143.1 - 1.3e-41 139.3 0.0 1e-05 25.7 0.0 9.5 9 0 0 9 9 9 8 Ankyrin repeat Ank_4 PF13637.6 EFO61143.1 - 8.9e-40 134.6 0.2 9.3e-11 42.0 0.0 7.2 3 3 3 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO61143.1 - 9.6e-40 134.1 3.9 0.00029 21.1 0.0 8.9 1 1 8 9 9 9 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61143.1 - 5.6e-37 121.6 0.0 0.00045 20.4 0.0 9.8 10 0 0 10 10 10 8 Ankyrin repeat Pkinase PF00069.25 EFO61143.1 - 7.3e-26 91.1 0.0 2.9e-25 89.1 0.0 1.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61143.1 - 8e-17 61.4 0.0 1.3e-16 60.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase VSP PF03302.13 EFO61144.1 - 5.3e-77 259.3 142.0 8.1e-45 153.4 29.9 4.9 1 1 4 5 5 5 4 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO61144.1 - 0.1 12.7 0.0 0.35 11.0 0.0 2.0 1 0 0 1 1 1 0 Podoplanin VSP PF03302.13 EFO61146.1 - 1.8e-05 23.8 36.8 1.8e-05 23.8 36.8 7.7 1 1 5 6 6 6 4 Giardia variant-specific surface protein VSP PF03302.13 EFO61148.1 - 3.8e-35 121.5 183.4 1.4e-26 93.3 66.2 7.6 1 1 4 5 5 5 4 Giardia variant-specific surface protein SKG6 PF08693.10 EFO61148.1 - 0.54 9.7 5.6 2.3 7.7 5.6 2.1 1 0 0 1 1 1 0 Transmembrane alpha-helix domain TMF_DNA_bd PF12329.8 EFO61150.1 - 0.0014 18.6 3.9 0.0014 18.6 3.9 2.4 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding DUF3972 PF13118.6 EFO61150.1 - 0.044 14.2 2.9 0.13 12.7 2.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3972) DUF4763 PF15960.5 EFO61150.1 - 0.14 11.5 12.2 0.008 15.5 4.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) DUF1664 PF07889.12 EFO61150.1 - 0.26 11.3 4.4 0.58 10.2 3.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4472 PF14739.6 EFO61150.1 - 0.72 10.6 13.1 0.05 14.4 2.9 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) FlaC_arch PF05377.11 EFO61150.1 - 0.99 9.8 4.0 7.1 7.1 2.5 2.8 2 1 0 2 2 1 0 Flagella accessory protein C (FlaC) DUF812 PF05667.11 EFO61150.1 - 1.1 8.1 21.4 0.023 13.6 14.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF812) Spc7 PF08317.11 EFO61150.1 - 1.1 8.0 17.4 2.2 7.1 17.4 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein AAA_13 PF13166.6 EFO61150.1 - 1.3 7.6 11.5 2.2 6.8 11.5 1.2 1 0 0 1 1 1 0 AAA domain Med7 PF05983.11 EFO61150.1 - 1.5 8.9 6.9 0.15 12.1 2.0 2.0 2 0 0 2 2 2 0 MED7 protein DUF16 PF01519.16 EFO61150.1 - 2.2 8.8 5.4 11 6.5 5.4 2.2 1 1 0 1 1 1 0 Protein of unknown function DUF16 UPF0242 PF06785.11 EFO61150.1 - 3.3 7.8 10.8 7.3 6.7 10.8 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DivIC PF04977.15 EFO61150.1 - 3.9 7.3 16.4 0.12 12.2 2.5 4.0 2 1 2 4 4 4 0 Septum formation initiator YabA PF06156.13 EFO61150.1 - 6.2 7.5 7.4 1.1 9.9 2.0 2.6 2 1 1 3 3 3 0 Initiation control protein YabA DUF4200 PF13863.6 EFO61150.1 - 8.2 6.9 18.0 0.26 11.7 11.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Pkinase PF00069.25 EFO61151.1 - 3.3e-34 118.5 0.0 2.1e-19 69.9 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61151.1 - 5.7e-08 32.4 0.0 0.0028 17.0 0.0 2.7 2 1 0 2 2 2 2 Protein tyrosine kinase VSP PF03302.13 EFO61152.1 - 4.3e-38 131.2 208.5 5.6e-27 94.6 79.5 7.9 1 1 3 4 4 4 3 Giardia variant-specific surface protein SKG6 PF08693.10 EFO61152.1 - 1.2 8.6 5.6 2.7 7.5 5.6 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain UFD1 PF03152.14 EFO61153.1 - 9.5e-42 142.4 0.0 1.3e-41 142.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 LIM PF00412.22 EFO61154.1 - 0.79 10.0 5.3 2.1 8.6 3.9 2.3 3 0 0 3 3 3 0 LIM domain Ribosomal_60s PF00428.19 EFO61155.1 - 2.8e-21 75.9 5.6 3.8e-21 75.5 5.6 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein Ank_2 PF12796.7 EFO61158.1 - 2e-92 303.9 4.5 1.9e-18 66.8 0.0 8.4 1 1 8 9 9 9 8 Ankyrin repeats (3 copies) Ank PF00023.30 EFO61158.1 - 5.6e-63 206.8 0.2 0.00017 21.9 0.0 14.2 14 1 0 14 14 14 10 Ankyrin repeat Ank_4 PF13637.6 EFO61158.1 - 2e-60 200.4 5.4 6e-09 36.3 0.2 12.1 6 3 6 12 12 12 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61158.1 - 8.2e-52 167.1 3.5 0.00066 19.9 0.0 14.4 15 0 0 15 15 14 11 Ankyrin repeat Ank_5 PF13857.6 EFO61158.1 - 1.5e-51 171.7 16.1 8.8e-06 25.9 0.1 12.3 4 2 8 12 12 12 10 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO61158.1 - 1.6e-26 93.3 0.0 6.8e-26 91.2 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61158.1 - 6.7e-20 71.5 0.0 1.5e-19 70.3 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3450 PF11932.8 EFO61158.1 - 0.0071 15.7 0.0 0.018 14.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) APH PF01636.23 EFO61158.1 - 0.022 14.7 0.6 0.051 13.5 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family GAS PF13851.6 EFO61158.1 - 0.05 12.9 0.3 0.05 12.9 0.3 1.6 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding HemY_N PF07219.13 EFO61158.1 - 0.13 12.5 0.3 0.13 12.5 0.3 2.7 2 0 0 2 2 2 0 HemY protein N-terminus DUF3584 PF12128.8 EFO61158.1 - 0.23 8.9 1.5 0.33 8.4 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CLZ PF16526.5 EFO61158.1 - 0.24 11.8 2.5 9 6.7 0.0 2.9 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels AATase PF07247.12 EFO61158.1 - 0.25 9.8 0.0 0.5 8.9 0.0 1.4 2 0 0 2 2 2 0 Alcohol acetyltransferase SerH PF06873.11 EFO61158.1 - 3.1 6.5 6.0 1.7 7.4 1.2 2.3 2 1 0 2 2 2 0 Cell surface immobilisation antigen SerH VSP PF03302.13 EFO61159.1 - 0.00048 19.1 74.8 0.00048 19.1 74.8 5.6 1 1 2 3 3 3 2 Giardia variant-specific surface protein VSP PF03302.13 EFO61160.1 - 1e-37 129.9 229.7 1.4e-15 57.1 46.0 9.1 1 1 7 8 8 8 7 Giardia variant-specific surface protein VSP PF03302.13 EFO61161.1 - 5.3e-72 242.9 103.2 1.7e-32 112.8 29.4 4.8 1 1 4 5 5 5 3 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO61161.1 - 0.046 13.8 0.1 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 Podoplanin SKG6 PF08693.10 EFO61161.1 - 0.21 11.1 5.0 0.4 10.1 5.0 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Peptidase_C1 PF00112.23 EFO61162.1 - 2.4e-31 109.5 0.5 5.4e-19 69.2 0.9 3.3 3 0 0 3 3 3 3 Papain family cysteine protease Helicase_C PF00271.31 EFO61163.1 - 8.3e-12 45.4 0.0 2e-11 44.2 0.0 1.7 1 1 0 1 1 1 1 Helicase conserved C-terminal domain Snapin_Pallidin PF14712.6 EFO61164.1 - 0.6 10.6 14.7 0.44 11.0 0.8 4.2 4 0 0 4 4 4 0 Snapin/Pallidin Apolipoprotein PF01442.18 EFO61164.1 - 1.7 8.4 5.9 2.8 7.8 1.8 3.3 3 1 0 3 3 3 0 Apolipoprotein A1/A4/E domain DUF948 PF06103.11 EFO61164.1 - 1.9 8.8 8.6 39 4.6 0.1 5.0 5 1 1 6 6 6 0 Bacterial protein of unknown function (DUF948) ABC_tran_CTD PF16326.5 EFO61164.1 - 3.1 8.1 9.6 8.3 6.7 0.2 4.0 3 1 0 3 3 3 0 ABC transporter C-terminal domain Syntaxin_2 PF14523.6 EFO61164.1 - 9.6 6.6 20.0 7 7.1 0.1 5.3 4 1 0 5 5 5 0 Syntaxin-like protein zf-U1 PF06220.12 EFO61166.1 - 3.8e-07 29.8 2.3 4.3e-07 29.6 2.3 1.1 1 0 0 1 1 1 1 U1 zinc finger zf-Di19 PF05605.12 EFO61166.1 - 0.059 13.7 0.0 0.067 13.5 0.0 1.2 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_9 PF16293.5 EFO61166.1 - 0.06 13.2 0.0 0.071 13.0 0.0 1.2 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) CCB1 PF12046.8 EFO61167.1 - 0.074 12.4 0.1 8.5 5.7 0.1 2.3 2 0 0 2 2 2 0 Cofactor assembly of complex C subunit B Ank_2 PF12796.7 EFO61168.1 - 1.6e-83 275.4 13.4 4e-19 69.0 0.2 6.2 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61168.1 - 6.8e-45 150.9 4.8 1.2e-08 35.3 0.1 8.5 7 1 2 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61168.1 - 1.4e-41 135.6 1.5 0.00013 22.1 0.0 11.8 12 0 0 12 12 12 9 Ankyrin repeat Ank_5 PF13857.6 EFO61168.1 - 2e-41 139.5 12.9 9.7e-05 22.6 0.0 9.3 3 3 5 9 9 9 9 Ankyrin repeats (many copies) Ank PF00023.30 EFO61168.1 - 1.4e-39 132.8 8.2 0.00011 22.5 0.0 11.1 10 1 1 11 11 11 8 Ankyrin repeat Phage_T7_Capsid PF05396.11 EFO61168.1 - 0.16 12.4 0.3 0.55 10.6 0.0 2.0 2 1 1 3 3 3 0 Phage T7 capsid assembly protein Ank_2 PF12796.7 EFO61169.1 - 1e-35 122.2 6.2 9.5e-15 55.0 0.1 3.8 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO61169.1 - 6.9e-29 101.0 0.0 1.4e-28 100.0 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Ank_5 PF13857.6 EFO61169.1 - 3.3e-21 75.1 6.4 5e-07 29.9 0.0 6.2 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61169.1 - 1.2e-19 68.3 4.8 0.0033 17.8 0.0 7.8 7 0 0 7 7 7 5 Ankyrin repeat Ank_4 PF13637.6 EFO61169.1 - 4.5e-19 68.6 2.2 0.00043 20.8 0.0 4.6 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO61169.1 - 3.4e-18 65.9 0.0 5.1e-18 65.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank PF00023.30 EFO61169.1 - 2.9e-15 55.9 7.0 0.0013 19.0 0.0 7.3 7 0 0 7 7 7 4 Ankyrin repeat 3HCDH_RFF PF18321.1 EFO61169.1 - 1.1 9.7 4.3 3.3 8.2 0.0 3.1 3 0 0 3 3 3 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain VSP PF03302.13 EFO61170.1 - 7.5e-76 255.5 152.8 1.6e-39 135.9 25.1 4.1 1 1 3 4 4 4 4 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO61170.1 - 0.0079 16.3 0.1 0.0079 16.3 0.1 2.8 3 0 0 3 3 3 1 Podoplanin SKG6 PF08693.10 EFO61170.1 - 0.088 12.2 5.0 0.18 11.2 5.0 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain NAD_binding_1 PF00175.21 EFO61171.1 - 5.6e-10 39.8 0.0 1.5e-09 38.5 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EFO61171.1 - 3.8e-08 33.6 0.0 7.5e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Globin PF00042.22 EFO61171.1 - 7.9e-05 23.2 0.2 0.015 15.8 0.0 2.8 3 0 0 3 3 3 1 Globin Protoglobin PF11563.8 EFO61171.1 - 0.023 14.6 0.4 0.21 11.5 0.4 2.1 1 1 0 1 1 1 0 Protoglobin NAD_binding_6 PF08030.12 EFO61171.1 - 0.036 14.2 0.0 0.063 13.4 0.0 1.3 1 0 0 1 1 1 0 Ferric reductase NAD binding domain DUF4474 PF14751.6 EFO61172.1 - 0.036 13.5 0.1 0.059 12.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4474) Histone PF00125.24 EFO61173.1 - 1.7e-24 86.7 0.6 2.1e-24 86.3 0.6 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFO61173.1 - 1.5e-05 25.2 1.1 9.9e-05 22.5 0.1 2.5 3 0 0 3 3 3 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EFO61173.1 - 0.0027 18.1 0.1 0.0045 17.4 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A TAF PF02969.17 EFO61173.1 - 0.0065 16.6 0.2 0.012 15.7 0.2 1.5 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-T_C PF15511.6 EFO61173.1 - 0.034 14.3 0.0 0.044 13.9 0.0 1.4 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold DAGK_prokar PF01219.19 EFO61173.1 - 0.16 11.8 0.4 0.3 10.9 0.4 1.4 1 1 0 1 1 1 0 Prokaryotic diacylglycerol kinase VSP PF03302.13 EFO61175.1 - 1.8e-82 277.4 281.6 1e-32 113.5 30.2 10.2 1 1 8 9 9 9 8 Giardia variant-specific surface protein Ank_2 PF12796.7 EFO61177.1 - 2.7e-197 639.9 46.1 5e-17 62.3 0.0 19.2 1 1 19 21 21 21 20 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61177.1 - 4.4e-118 384.3 40.8 4.7e-08 33.4 0.0 24.7 14 6 9 24 24 24 21 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61177.1 - 1.4e-104 329.2 26.3 0.0053 17.2 0.0 34.9 33 2 2 35 35 35 23 Ankyrin repeat Ank PF00023.30 EFO61177.1 - 1.1e-100 326.0 22.0 0.0012 19.2 0.0 30.4 29 3 3 32 32 31 23 Ankyrin repeat Ank_5 PF13857.6 EFO61177.1 - 2.3e-99 324.1 45.0 2.9e-06 27.5 0.0 27.6 9 5 18 29 29 29 23 Ankyrin repeats (many copies) RHD3 PF05879.12 EFO61177.1 - 1.7e-45 155.5 5.6 3.9e-43 147.7 0.0 2.2 2 0 0 2 2 2 2 Root hair defective 3 GTP-binding protein (RHD3) Pkinase PF00069.25 EFO61177.1 - 4.9e-33 114.6 0.1 2e-32 112.6 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61177.1 - 2.4e-25 89.3 0.0 6.6e-25 87.9 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase MMR_HSR1 PF01926.23 EFO61177.1 - 2.3e-06 27.7 0.2 2.1e-05 24.6 0.0 2.8 3 0 0 3 3 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFO61177.1 - 0.00035 20.7 1.3 0.0019 18.3 0.0 2.7 3 0 0 3 3 3 1 Dynamin family HemY_N PF07219.13 EFO61177.1 - 0.0018 18.5 0.9 0.38 11.0 0.3 3.7 2 0 0 2 2 2 1 HemY protein N-terminus Phage_T7_Capsid PF05396.11 EFO61177.1 - 0.018 15.4 12.9 3.4 8.0 0.0 6.6 7 1 1 8 8 8 0 Phage T7 capsid assembly protein AAA_28 PF13521.6 EFO61177.1 - 0.031 14.5 0.5 0.15 12.3 0.1 2.5 2 0 0 2 2 1 0 AAA domain APH PF01636.23 EFO61177.1 - 0.05 13.5 0.0 0.15 12.0 0.0 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFO61177.1 - 0.067 12.8 0.0 0.18 11.3 0.0 1.7 1 0 0 1 1 1 0 Choline/ethanolamine kinase RNA_helicase PF00910.22 EFO61177.1 - 0.12 12.8 0.0 0.47 10.9 0.0 2.1 1 0 0 1 1 1 0 RNA helicase LPD7 PF18821.1 EFO61177.1 - 0.23 11.6 4.7 0.42 10.8 0.1 3.1 3 0 0 3 3 2 0 Large polyvalent protein-associated domain 7 DUF572 PF04502.13 EFO61177.1 - 1.2 8.6 5.9 2.5 7.7 5.9 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF572) VSP PF03302.13 EFO61178.1 - 1e-192 640.3 193.8 2.4e-177 589.7 119.6 3.1 1 1 2 3 3 3 3 Giardia variant-specific surface protein cEGF PF12662.7 EFO61178.1 - 0.054 13.4 0.4 0.054 13.4 0.4 8.1 9 0 0 9 9 9 0 Complement Clr-like EGF-like Ebp2 PF05890.12 EFO61181.1 - 2.8e-17 63.1 15.4 3.4e-17 62.9 15.4 1.1 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 HU-DNA_bdg PF14848.6 EFO61183.1 - 0.13 12.3 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 DNA-binding domain SNARE PF05739.19 EFO61186.1 - 0.014 15.3 0.0 0.042 13.8 0.0 1.7 1 0 0 1 1 1 0 SNARE domain Arteri_Gl PF00951.18 EFO61186.1 - 0.18 11.6 0.8 0.32 10.8 0.2 1.7 1 1 1 2 2 2 0 Arterivirus GL envelope glycoprotein Cullin_Nedd8 PF10557.9 EFO61187.1 - 0.022 14.8 0.0 0.068 13.2 0.0 1.9 1 0 0 1 1 1 0 Cullin protein neddylation domain TTL PF03133.15 EFO61188.1 - 1e-57 195.5 0.2 3.2e-38 131.5 0.0 3.2 3 0 0 3 3 3 3 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EFO61188.1 - 0.00014 21.2 0.0 0.0024 17.2 0.0 2.4 2 0 0 2 2 2 1 YheC/D like ATP-grasp MFS_1 PF07690.16 EFO61189.1 - 5.8e-24 84.7 14.8 1.5e-17 63.6 1.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFO61189.1 - 3.6e-05 22.8 12.2 0.0023 16.9 4.9 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 EFO61189.1 - 0.00034 19.6 12.1 0.002 17.1 6.0 2.5 2 1 0 3 3 3 2 MFS_1 like family Per1 PF04080.13 EFO61189.1 - 0.076 12.8 0.8 0.58 9.9 0.9 2.2 2 0 0 2 2 2 0 Per1-like family EamA PF00892.20 EFO61190.1 - 2.7e-07 30.8 14.7 2.6e-05 24.4 2.2 4.4 3 1 1 4 4 4 2 EamA-like transporter family UAA PF08449.11 EFO61190.1 - 1.9e-05 24.0 1.8 2.7e-05 23.5 0.1 1.9 2 0 0 2 2 2 1 UAA transporter family Mg_trans_NIPA PF05653.14 EFO61190.1 - 0.00011 21.4 4.5 0.00011 21.4 4.5 2.0 2 1 0 2 2 2 1 Magnesium transporter NIPA Nuc_sug_transp PF04142.15 EFO61190.1 - 0.0014 17.9 3.3 0.041 13.1 3.2 2.5 2 1 0 2 2 2 1 Nucleotide-sugar transporter DUF4131 PF13567.6 EFO61190.1 - 0.0027 17.4 7.4 0.009 15.7 0.3 3.1 3 1 0 3 3 3 1 Domain of unknown function (DUF4131) SLC35F PF06027.12 EFO61190.1 - 0.0035 16.9 5.6 0.0043 16.6 4.2 1.8 2 0 0 2 2 2 1 Solute carrier family 35 PUNUT PF16913.5 EFO61190.1 - 0.025 13.8 4.7 0.013 14.7 1.6 2.2 2 1 1 3 3 3 0 Purine nucleobase transmembrane transport TMEM234 PF10639.9 EFO61190.1 - 0.055 13.5 2.5 4.1 7.5 0.0 2.9 2 1 1 3 3 3 0 Putative transmembrane family 234 VSP PF03302.13 EFO61192.1 - 8.5e-76 255.3 168.2 1.3e-71 241.5 90.6 4.3 1 1 1 3 3 3 2 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO61192.1 - 1.1e-05 25.5 13.7 1.1e-05 25.5 13.7 12.8 2 2 12 14 14 14 4 Furin-like repeat, cysteine-rich VSP PF03302.13 EFO61193.1 - 1.1e-172 574.4 238.8 8.4e-150 499.0 104.6 7.0 1 1 6 7 7 7 7 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO61193.1 - 0.069 13.3 0.1 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 Podoplanin SKG6 PF08693.10 EFO61193.1 - 0.41 10.1 5.0 0.75 9.2 5.0 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Drc1-Sld2 PF11719.8 EFO61194.1 - 0.01 15.5 0.9 0.018 14.6 0.4 1.6 1 1 0 1 1 1 0 DNA replication and checkpoint protein DUF3970 PF13113.6 EFO61194.1 - 1.2 9.4 3.4 19 5.6 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3970) VSP PF03302.13 EFO61195.1 - 2.9e-38 131.8 187.1 1.7e-27 96.3 68.1 5.5 1 1 2 3 3 3 3 Giardia variant-specific surface protein PK PF00224.21 EFO61196.1 - 7.1e-57 192.9 0.2 9.7e-57 192.4 0.2 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 EFO61196.1 - 1.4e-15 57.5 1.2 7e-15 55.3 0.2 2.6 2 1 0 2 2 2 1 Pyruvate kinase, alpha/beta domain DHquinase_I PF01487.15 EFO61196.1 - 0.004 17.4 0.0 0.0081 16.4 0.0 1.4 1 0 0 1 1 1 1 Type I 3-dehydroquinase HpcH_HpaI PF03328.14 EFO61196.1 - 0.016 14.4 0.0 0.038 13.1 0.0 1.6 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family Kelch_4 PF13418.6 EFO61197.1 - 1.3e-15 57.1 0.3 1.8e-06 27.9 0.0 4.2 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_3 PF13415.6 EFO61197.1 - 9.7e-10 38.5 2.1 4.6e-05 23.6 0.1 3.8 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EFO61197.1 - 3.3e-09 36.2 1.8 0.001 18.6 0.1 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 EFO61197.1 - 1e-06 28.8 3.7 0.03 14.6 0.1 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 EFO61197.1 - 3.3e-06 26.9 5.3 0.0002 21.2 0.0 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 EFO61197.1 - 0.0038 17.1 1.0 1.4 9.0 0.0 3.2 3 0 0 3 3 3 1 Kelch motif AdoMet_MTase PF07757.13 EFO61197.1 - 0.18 12.1 0.0 0.4 11.0 0.0 1.5 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase RRM_1 PF00076.22 EFO61198.1 - 0.0082 15.9 0.0 2.6 7.9 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFO61198.1 - 0.079 12.8 0.0 0.2 11.5 0.0 1.6 2 0 0 2 2 2 0 Occluded RNA-recognition motif Dehydrin PF00257.19 EFO61198.1 - 0.13 12.8 0.5 0.2 12.2 0.5 1.2 1 0 0 1 1 1 0 Dehydrin TPR_2 PF07719.17 EFO61199.1 - 6.1e-05 22.8 0.2 0.1 12.8 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFO61199.1 - 0.00073 20.0 0.4 0.015 15.8 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFO61199.1 - 0.0082 16.4 0.2 0.94 10.0 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFO61199.1 - 0.02 15.7 0.1 1.2e+02 4.0 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFO61199.1 - 0.031 14.1 0.5 0.17 11.8 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_20 PF14561.6 EFO61199.1 - 0.033 14.5 0.0 1.1 9.6 0.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFO61199.1 - 0.31 11.7 1.0 3.8 8.2 0.0 2.8 3 1 1 4 4 4 0 Tetratricopeptide repeat Ank_2 PF12796.7 EFO61201.1 - 3.7e-74 245.3 27.3 1.9e-16 60.4 0.2 11.1 2 2 11 14 14 14 11 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61201.1 - 1.9e-38 130.0 20.1 2.2e-06 27.8 0.0 14.1 5 2 8 14 14 14 10 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61201.1 - 3.9e-37 126.1 12.6 0.0001 22.8 0.1 11.9 10 3 2 12 12 12 10 Ankyrin repeats (many copies) Ank PF00023.30 EFO61201.1 - 3.3e-33 112.7 18.3 0.0051 17.2 0.1 15.7 16 0 0 16 16 16 10 Ankyrin repeat Ank_3 PF13606.6 EFO61201.1 - 5.7e-30 100.0 18.2 0.0015 18.9 0.0 17.7 19 0 0 19 19 19 7 Ankyrin repeat Pkinase PF00069.25 EFO61202.1 - 2e-53 181.5 0.0 2.3e-53 181.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61202.1 - 2e-20 73.2 0.0 3.9e-20 72.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase HMG_box PF00505.19 EFO61203.1 - 8.1e-07 29.4 5.9 8.1e-07 29.4 5.9 2.6 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFO61203.1 - 1.5e-05 25.5 4.0 0.0028 18.2 3.0 2.5 2 0 0 2 2 2 2 HMG-box domain DUF3106 PF11304.8 EFO61203.1 - 0.038 14.5 7.5 0.33 11.4 2.9 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3106) MlaC PF05494.12 EFO61203.1 - 0.055 13.2 0.3 0.2 11.4 0.1 1.8 2 0 0 2 2 2 0 MlaC protein Stevor PF17410.2 EFO61203.1 - 0.11 12.0 3.1 0.16 11.5 3.1 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame GIY-YIG PF01541.24 EFO61203.1 - 0.17 12.2 3.2 0.29 11.4 3.2 1.4 1 0 0 1 1 1 0 GIY-YIG catalytic domain Methyltransf_15 PF09445.10 EFO61204.1 - 5.4e-12 45.6 0.0 7.3e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase SAM_MT PF04445.13 EFO61204.1 - 0.006 16.0 0.0 0.0079 15.6 0.0 1.2 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase Cons_hypoth95 PF03602.15 EFO61204.1 - 0.015 14.9 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Met_10 PF02475.16 EFO61204.1 - 0.074 12.8 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein TPR_12 PF13424.6 EFO61205.1 - 6.9e-06 26.3 0.4 0.021 15.1 0.2 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFO61205.1 - 0.0026 17.5 1.1 1.2 9.0 0.0 4.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFO61205.1 - 0.0045 17.0 2.3 10 6.5 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFO61205.1 - 0.019 15.1 0.5 0.27 11.4 1.5 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat FapA PF03961.13 EFO61205.1 - 0.042 12.5 0.8 0.061 11.9 0.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Syntaxin-6_N PF09177.11 EFO61205.1 - 0.19 12.3 4.6 0.95 10.1 0.2 3.2 3 1 0 3 3 3 0 Syntaxin 6, N-terminal TPR_17 PF13431.6 EFO61205.1 - 0.24 11.9 0.9 6.9 7.3 0.0 3.5 4 1 0 4 4 4 0 Tetratricopeptide repeat DHR10 PF18595.1 EFO61205.1 - 1.7 8.8 8.1 1.4 9.0 6.7 1.6 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain DUF515 PF04415.12 EFO61205.1 - 3 6.1 5.8 1.6 7.1 3.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF515) Ank_2 PF12796.7 EFO61206.1 - 7e-66 218.8 8.8 5.7e-13 49.3 0.1 6.6 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61206.1 - 2.6e-42 142.3 12.6 0.0013 19.0 0.0 10.6 3 3 7 10 10 10 10 Ankyrin repeats (many copies) Ank PF00023.30 EFO61206.1 - 4.2e-42 140.8 0.6 0.00096 19.5 0.0 11.6 11 0 0 11 11 11 10 Ankyrin repeat Ank_4 PF13637.6 EFO61206.1 - 6.1e-42 141.5 5.1 1.9e-08 34.7 0.0 7.7 5 1 3 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61206.1 - 7.7e-39 127.3 3.2 0.025 15.1 0.0 11.7 11 0 0 11 11 11 11 Ankyrin repeat Pkinase PF00069.25 EFO61206.1 - 4.8e-23 81.9 0.4 1e-22 80.8 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61206.1 - 2.7e-14 53.1 0.1 8.4e-14 51.5 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO61206.1 - 0.00094 18.6 0.0 0.0022 17.4 0.0 1.6 1 0 0 1 1 1 1 Kinase-like KIND PF16474.5 EFO61206.1 - 0.062 13.2 0.0 0.5 10.3 0.0 2.4 2 0 0 2 2 2 0 Kinase non-catalytic C-lobe domain Ank_2 PF12796.7 EFO61207.1 - 4.4e-21 75.3 0.7 3.4e-09 37.1 0.2 3.9 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61207.1 - 8.5e-12 45.1 0.4 4.2e-05 23.7 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61207.1 - 1.6e-09 38.1 0.6 0.00046 20.7 0.0 6.0 3 1 4 7 7 7 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO61207.1 - 6.8e-08 32.6 0.3 0.045 14.2 0.0 5.6 4 1 1 5 5 5 2 Ankyrin repeat Ank_3 PF13606.6 EFO61207.1 - 4.4e-07 29.7 0.3 1.6 9.5 0.0 6.3 7 0 0 7 7 7 2 Ankyrin repeat Pep3_Vps18 PF05131.14 EFO61208.1 - 2.3e-06 27.5 1.1 0.00067 19.5 0.1 3.3 3 0 0 3 3 3 2 Pep3/Vps18/deep orange family zf-RING_UBOX PF13445.6 EFO61208.1 - 0.11 12.5 5.0 0.12 12.4 2.9 2.3 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_2 PF13639.6 EFO61208.1 - 1.1 9.6 12.1 15 6.0 7.3 3.9 2 1 0 2 2 2 0 Ring finger domain CTP_transf_like PF01467.26 EFO61209.1 - 7.7e-17 61.8 0.0 9.5e-17 61.5 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like TGT PF01702.18 EFO61210.1 - 1.2e-124 416.1 0.0 1.4e-124 415.8 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase DUF2013 PF09431.10 EFO61211.1 - 0.032 14.4 1.6 0.25 11.5 1.6 2.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2013) RHD3 PF05879.12 EFO61212.1 - 4.5e-69 233.4 1.1 2.9e-66 224.1 0.2 3.1 2 1 0 2 2 2 2 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.23 EFO61212.1 - 5.3e-05 23.3 0.0 0.00015 21.8 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFO61212.1 - 0.0002 21.5 0.2 0.00054 20.0 0.2 1.7 1 0 0 1 1 1 1 Dynamin family GBP PF02263.19 EFO61212.1 - 0.00029 20.2 0.0 0.00056 19.3 0.0 1.4 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain AAA_16 PF13191.6 EFO61212.1 - 0.0027 18.1 0.0 0.013 15.9 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain Condensin2nSMC PF12422.8 EFO61212.1 - 0.043 14.0 0.0 0.69 10.1 0.0 2.8 2 0 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit RNB PF00773.19 EFO61217.1 - 2e-82 277.1 1.6 3.1e-82 276.5 1.6 1.2 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 EFO61217.1 - 1.3e-09 37.9 0.0 3.4e-09 36.6 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 EFO61217.1 - 1.3e-06 28.5 0.0 3.3e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 Cold shock domain HPPK PF01288.20 EFO61217.1 - 0.084 13.4 0.0 0.97 10.0 0.0 2.5 2 0 0 2 2 2 0 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) Ank_2 PF12796.7 EFO61218.1 - 7.3e-20 71.4 7.0 8.5e-11 42.3 0.3 3.1 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61218.1 - 6.3e-12 45.5 6.6 4e-07 30.2 0.0 4.5 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61218.1 - 6.4e-12 44.6 1.9 0.27 11.9 0.1 5.3 5 0 0 5 5 4 3 Ankyrin repeat Ank_4 PF13637.6 EFO61218.1 - 1.7e-10 41.2 4.1 0.00015 22.3 0.1 4.4 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO61218.1 - 1.3e-09 38.1 5.4 0.021 15.2 0.2 4.9 3 1 0 3 3 3 3 Ankyrin repeat DUF4407 PF14362.6 EFO61218.1 - 2.8e-05 23.6 27.6 0.00031 20.2 13.1 5.8 1 1 3 5 5 5 2 Domain of unknown function (DUF4407) FAM76 PF16046.5 EFO61218.1 - 0.0002 20.8 1.9 0.0002 20.8 1.9 6.5 3 1 4 7 7 5 2 FAM76 protein DUF4164 PF13747.6 EFO61218.1 - 0.0025 18.1 3.5 0.0025 18.1 3.5 7.3 4 2 2 6 6 6 1 Domain of unknown function (DUF4164) Fez1 PF06818.15 EFO61218.1 - 0.019 15.4 66.0 0.9 10.0 18.7 5.7 2 2 2 4 4 4 0 Fez1 HALZ PF02183.18 EFO61218.1 - 0.025 14.8 0.5 0.025 14.8 0.5 6.9 7 0 0 7 7 6 0 Homeobox associated leucine zipper DUF3800 PF12686.7 EFO61218.1 - 0.029 15.0 0.0 1.1 9.9 0.0 3.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) DUF2046 PF09755.9 EFO61218.1 - 0.7 9.1 49.2 0.027 13.7 3.4 5.2 2 1 3 5 5 5 0 Uncharacterized conserved protein H4 (DUF2046) UPF0242 PF06785.11 EFO61218.1 - 0.95 9.5 65.9 1.8 8.7 0.6 6.8 2 1 6 8 8 8 0 Uncharacterised protein family (UPF0242) N-terminus Jnk-SapK_ap_N PF09744.9 EFO61218.1 - 3 8.1 59.2 0.18 12.0 11.8 5.8 2 1 4 6 6 6 0 JNK_SAPK-associated protein-1 WD40_alt PF14077.6 EFO61218.1 - 3 7.8 6.8 17 5.4 0.1 4.6 4 0 0 4 4 4 0 Alternative WD40 repeat motif Trimer_CC PF08954.11 EFO61218.1 - 5.7 6.6 16.4 21 4.8 0.1 5.9 5 0 0 5 5 5 0 Trimerisation motif LURAP PF14854.6 EFO61218.1 - 6.4 6.8 12.8 15 5.5 0.0 5.1 4 1 1 5 5 5 0 Leucine rich adaptor protein DUF2703 PF10865.8 EFO61218.1 - 6.4 7.0 9.4 3.1 8.0 0.4 3.7 3 2 1 4 4 3 0 Domain of unknown function (DUF2703) TSC22 PF01166.18 EFO61218.1 - 7.1 7.0 28.8 6.6 7.1 0.2 8.0 8 1 1 9 9 8 0 TSC-22/dip/bun family Med10 PF09748.9 EFO61218.1 - 8.9 6.3 11.1 9.6 6.2 0.1 4.6 3 1 0 3 3 3 0 Transcription factor subunit Med10 of Mediator complex Pkinase PF00069.25 EFO61219.1 - 2.5e-35 122.1 0.0 5.5e-34 117.7 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61219.1 - 2.6e-13 49.9 0.0 6.3e-12 45.3 0.0 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFO61219.1 - 0.043 12.6 0.0 0.11 11.2 0.0 1.7 1 1 0 1 1 1 0 Fungal protein kinase MYO10_CC PF16735.5 EFO61219.1 - 0.14 12.3 1.0 0.28 11.3 1.0 1.5 1 0 0 1 1 1 0 Unconventional myosin-X coiled coil domain Helicase_C PF00271.31 EFO61220.1 - 2e-10 41.0 0.1 6.4e-10 39.4 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFO61220.1 - 1.2e-05 25.2 0.0 2.5e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EFO61220.1 - 1.9e-05 24.8 0.0 4e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EFO61220.1 - 0.00037 20.8 0.0 0.0014 18.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EFO61220.1 - 0.016 14.3 0.1 0.027 13.5 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.6 EFO61220.1 - 0.1 13.0 0.0 0.31 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain Rad17 PF03215.15 EFO61220.1 - 0.12 12.3 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain IstB_IS21 PF01695.17 EFO61220.1 - 0.15 11.8 0.0 9.4 5.9 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein Ank_2 PF12796.7 EFO61221.1 - 4.3e-29 100.9 0.4 1.2e-11 45.1 0.0 3.4 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61221.1 - 2.9e-18 65.7 0.8 1.7e-09 37.7 0.0 3.8 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61221.1 - 2.7e-13 48.8 0.6 0.036 14.6 0.0 4.9 6 0 0 6 6 6 3 Ankyrin repeat Ank_4 PF13637.6 EFO61221.1 - 4.7e-13 49.4 0.6 4.3e-08 33.5 0.0 3.8 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO61221.1 - 7e-13 48.4 2.3 0.0036 17.7 0.0 5.4 6 0 0 6 6 6 3 Ankyrin repeat POB3_N PF17292.2 EFO61221.1 - 0.029 14.8 0.0 7.9 7.0 0.0 2.3 2 0 0 2 2 2 0 POB3-like N-terminal PH domain Pyridoxal_deC PF00282.19 EFO61221.1 - 0.11 11.2 0.0 0.15 10.7 0.0 1.1 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain RNase_P_p30 PF01876.16 EFO61223.1 - 1.8e-12 47.2 0.0 4.2e-12 46.0 0.0 1.6 1 1 0 1 1 1 1 RNase P subunit p30 DUF4201 PF13870.6 EFO61224.1 - 0.004 16.9 8.5 0.22 11.3 2.6 2.8 3 0 0 3 3 3 2 Domain of unknown function (DUF4201) NPV_P10 PF05531.12 EFO61224.1 - 0.0094 16.4 14.4 0.14 12.6 0.7 4.9 3 2 1 4 4 4 1 Nucleopolyhedrovirus P10 protein APG6_N PF17675.1 EFO61224.1 - 0.011 16.3 17.3 0.59 10.7 8.4 3.3 2 1 1 3 3 3 0 Apg6 coiled-coil region DUF3837 PF12939.7 EFO61224.1 - 0.014 15.8 2.0 0.039 14.4 0.0 2.6 3 1 0 3 3 3 0 Domain of unknown function (DUF3837) TRPM_tetra PF16519.5 EFO61224.1 - 0.025 14.7 1.5 5.4 7.2 0.1 3.0 2 0 0 2 2 2 0 Tetramerisation domain of TRPM Allexi_40kDa PF05549.11 EFO61224.1 - 0.031 13.8 6.1 0.41 10.1 0.4 3.0 1 1 1 2 2 2 0 Allexivirus 40kDa protein DUF4774 PF15999.5 EFO61224.1 - 0.063 13.1 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4774) Methyltransf_30 PF05430.11 EFO61224.1 - 0.11 12.4 0.0 0.3 11.0 0.0 1.8 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase IPPT PF01715.17 EFO61224.1 - 0.19 11.5 7.0 3 7.6 7.0 2.0 1 1 0 1 1 1 0 IPP transferase Occludin_ELL PF07303.13 EFO61224.1 - 0.26 12.0 6.1 0.46 11.2 1.3 3.0 3 1 0 3 3 3 0 Occludin homology domain DUF4164 PF13747.6 EFO61224.1 - 0.27 11.6 8.8 0.6 10.4 0.2 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4164) KxDL PF10241.9 EFO61224.1 - 0.29 11.4 11.6 0.16 12.2 2.1 3.4 2 1 1 3 3 3 0 Uncharacterized conserved protein STAR_dimer PF16544.5 EFO61224.1 - 0.32 10.6 7.4 2 8.1 0.1 3.7 3 1 1 4 4 4 0 Homodimerisation region of STAR domain protein DASH_Dam1 PF08653.10 EFO61224.1 - 0.32 10.8 6.4 1.8 8.5 0.3 3.7 3 1 0 3 3 3 0 DASH complex subunit Dam1 DASH_Dad2 PF08654.10 EFO61224.1 - 0.46 10.9 12.0 3.9 8.0 1.2 4.0 3 1 1 4 4 4 0 DASH complex subunit Dad2 FlaC_arch PF05377.11 EFO61224.1 - 0.98 9.9 14.4 2.3 8.7 0.2 5.0 4 2 1 5 5 5 0 Flagella accessory protein C (FlaC) ABC_tran_CTD PF16326.5 EFO61224.1 - 1.1 9.5 20.1 0.41 10.9 1.1 4.9 3 2 2 5 5 5 0 ABC transporter C-terminal domain Baculo_PEP_C PF04513.12 EFO61224.1 - 1.2 9.2 16.6 2.1 8.4 9.2 3.4 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Snapin_Pallidin PF14712.6 EFO61224.1 - 1.5 9.3 20.8 0.037 14.4 6.6 4.1 3 2 1 5 5 5 0 Snapin/Pallidin CCDC53 PF10152.9 EFO61224.1 - 1.5 9.2 7.4 2.3 8.6 0.5 2.9 2 1 1 3 3 3 0 Subunit CCDC53 of WASH complex ALIX_LYPXL_bnd PF13949.6 EFO61224.1 - 2.2 7.5 11.6 52 3.0 0.0 3.1 1 1 0 2 2 2 0 ALIX V-shaped domain binding to HIV Enkurin PF13864.6 EFO61224.1 - 2.3 8.7 8.4 1.7 9.1 2.2 3.0 2 1 1 3 3 3 0 Calmodulin-binding Laminin_II PF06009.12 EFO61224.1 - 3.9 7.5 11.4 1.2 9.1 3.7 3.0 2 1 1 3 3 3 0 Laminin Domain II DASH_Dad4 PF08650.10 EFO61224.1 - 6.2 6.9 9.4 0.51 10.4 0.7 3.3 4 1 0 4 4 3 0 DASH complex subunit Dad4 Med9 PF07544.13 EFO61224.1 - 6.2 7.0 11.0 34 4.6 0.2 3.9 4 0 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 DUF16 PF01519.16 EFO61224.1 - 7.8 7.0 11.7 0.22 12.0 2.1 2.9 3 1 1 4 4 3 0 Protein of unknown function DUF16 RabGAP-TBC PF00566.18 EFO61225.1 - 2e-06 27.7 0.1 4e-06 26.6 0.1 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain FAE1_CUT1_RppA PF08392.12 EFO61226.1 - 1.2e-87 293.9 0.1 1.8e-87 293.3 0.1 1.2 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein ACP_syn_III_C PF08541.10 EFO61226.1 - 5e-11 42.6 0.0 1.9e-10 40.7 0.0 2.0 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Chal_sti_synt_C PF02797.15 EFO61226.1 - 3.8e-09 36.7 0.0 7.6e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain Chal_sti_synt_N PF00195.19 EFO61226.1 - 0.0076 15.7 0.0 0.014 14.8 0.0 1.4 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain HTH_53 PF18606.1 EFO61226.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Zap helix turn helix N-terminal domain ASF1_hist_chap PF04729.13 EFO61227.1 - 1.9e-10 40.9 0.0 3e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 ASF1 like histone chaperone IreB PF06135.12 EFO61228.1 - 0.11 12.7 0.0 0.33 11.2 0.0 1.8 1 0 0 1 1 1 0 IreB regulatory phosphoprotein Proteasome PF00227.26 EFO61229.1 - 2e-39 135.1 0.0 7.4e-39 133.2 0.0 1.8 1 1 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFO61229.1 - 1.9e-08 33.9 0.9 4e-08 32.8 0.1 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature ThiF PF00899.21 EFO61230.1 - 1.4e-35 122.8 0.4 1.7e-35 122.6 0.4 1.0 1 0 0 1 1 1 1 ThiF family UDPG_MGDP_dh_N PF03721.14 EFO61230.1 - 0.0021 17.7 2.9 0.0041 16.7 2.8 1.5 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.20 EFO61230.1 - 0.0044 17.1 1.0 0.0079 16.3 0.7 1.5 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EFO61230.1 - 0.006 16.8 3.5 0.08 13.2 3.5 2.2 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 EFO61230.1 - 0.014 15.0 0.1 0.028 14.1 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AlaDh_PNT_C PF01262.21 EFO61230.1 - 0.016 14.5 0.4 0.022 14.1 0.4 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 EFO61230.1 - 0.057 12.7 0.9 0.079 12.2 0.9 1.2 1 0 0 1 1 1 0 FAD binding domain NAD_binding_7 PF13241.6 EFO61230.1 - 0.13 12.8 1.0 0.32 11.5 1.0 1.8 1 1 0 1 1 1 0 Putative NAD(P)-binding Ank_2 PF12796.7 EFO61231.1 - 5.1e-13 49.4 2.5 1.1e-09 38.7 0.4 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61231.1 - 3e-07 30.9 0.5 0.00089 19.8 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61231.1 - 1.3e-05 25.2 0.2 0.024 15.2 0.0 4.0 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 EFO61231.1 - 0.0013 19.1 0.2 0.15 12.6 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EFO61231.1 - 0.011 16.0 0.6 2 8.9 0.0 3.5 3 1 1 4 4 4 0 Ankyrin repeats (many copies) Kinesin PF00225.23 EFO61232.1 - 5.9e-90 301.6 0.0 5.9e-90 301.6 0.0 1.9 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFO61232.1 - 9.3e-19 67.8 0.2 4.1e-18 65.8 0.0 2.3 2 0 0 2 2 2 1 Microtubule binding FAM184 PF15665.5 EFO61232.1 - 0.00066 19.5 15.7 0.00066 19.5 15.7 3.0 2 1 1 3 3 3 1 Family with sequence similarity 184, A and B DUF1319 PF07028.11 EFO61232.1 - 0.4 10.9 8.4 1.7 8.9 4.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1319) DNA_photolyase PF00875.18 EFO61232.1 - 0.65 10.0 3.9 0.46 10.5 1.6 1.9 2 0 0 2 2 2 0 DNA photolyase Rootletin PF15035.6 EFO61232.1 - 1 9.3 24.7 0.13 12.2 8.2 4.0 3 1 1 4 4 4 0 Ciliary rootlet component, centrosome cohesion DNA_ligase_A_M PF01068.21 EFO61232.1 - 7.8 6.1 9.4 3.8 7.1 6.7 1.8 2 0 0 2 2 2 0 ATP dependent DNA ligase domain Kinesin PF00225.23 EFO61233.1 - 1.9e-47 161.8 0.0 3e-47 161.2 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFO61233.1 - 3.9e-12 46.4 0.0 8.4e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding LAG1-DNAbind PF09271.11 EFO61233.1 - 0.057 14.0 0.2 0.26 11.9 0.2 2.0 2 0 0 2 2 2 0 LAG1, DNA binding DUSP PF06337.12 EFO61233.1 - 0.089 13.4 0.4 1.5 9.5 0.5 2.7 3 0 0 3 3 3 0 DUSP domain HOOK PF05622.12 EFO61233.1 - 0.44 8.6 11.8 0.64 8.1 11.8 1.1 1 0 0 1 1 1 0 HOOK protein OmpH PF03938.14 EFO61233.1 - 0.57 10.5 7.8 0.58 10.5 2.5 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) YabA PF06156.13 EFO61233.1 - 1.1 9.9 6.8 6.4 7.5 0.1 2.9 2 1 1 3 3 3 0 Initiation control protein YabA DUF4763 PF15960.5 EFO61233.1 - 1.3 8.3 8.8 0.18 11.1 3.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) APG6_N PF17675.1 EFO61233.1 - 1.7 9.2 17.3 3.2 8.3 8.1 2.3 1 1 0 2 2 2 0 Apg6 coiled-coil region DUF4407 PF14362.6 EFO61233.1 - 4.7 6.5 9.9 8.1 5.7 9.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HMMR_C PF15908.5 EFO61233.1 - 9.3 6.5 7.7 1.4 9.2 0.4 2.5 2 1 0 2 2 2 0 Hyaluronan mediated motility receptor C-terminal Siva PF05458.12 EFO61234.1 - 0.00071 19.3 17.2 0.00077 19.2 17.2 1.2 1 0 0 1 1 1 1 Cd27 binding protein (Siva) HypA PF01155.19 EFO61234.1 - 9.2 6.3 18.0 5.7e+02 0.5 18.0 2.3 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Proteasom_PSMB PF10508.9 EFO61235.1 - 0.0039 15.8 0.8 0.012 14.2 0.1 2.0 3 0 0 3 3 3 1 Proteasome non-ATPase 26S subunit RICTOR_N PF14664.6 EFO61235.1 - 0.019 13.9 6.9 0.19 10.7 0.3 2.9 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.6 EFO61235.1 - 0.53 10.1 2.9 0.73 9.6 0.1 2.5 2 1 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain PGM_PMM_I PF02878.16 EFO61237.1 - 1.7e-07 31.0 0.0 2.6e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I ATP_bind_3 PF01171.20 EFO61238.1 - 5.9e-14 52.2 0.0 6.7e-08 32.5 0.0 2.5 2 0 0 2 2 2 2 PP-loop family PAPS_reduct PF01507.19 EFO61238.1 - 0.009 16.1 0.0 0.73 9.8 0.0 2.3 2 0 0 2 2 2 2 Phosphoadenosine phosphosulfate reductase family zf-FPG_IleRS PF06827.14 EFO61238.1 - 0.77 9.7 8.9 3.3 7.7 0.4 3.0 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS NPV_P10 PF05531.12 EFO61239.1 - 0.019 15.4 3.7 1.3 9.5 0.1 3.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Vip3A_N PF12495.8 EFO61239.1 - 0.083 12.8 3.9 0.071 13.0 0.8 2.4 2 0 0 2 2 2 0 Vegetative insecticide protein 3A N terminal SlyX PF04102.12 EFO61239.1 - 1.8 9.2 8.5 0.5 11.0 0.5 3.6 3 0 0 3 3 3 0 SlyX Ank_2 PF12796.7 EFO61240.1 - 2e-24 86.0 6.6 2.2e-08 34.6 0.1 4.3 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61240.1 - 9e-15 54.8 5.7 1.3e-05 25.7 0.3 5.4 4 2 1 5 5 5 5 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO61240.1 - 1.2e-12 47.8 0.0 9.3e-08 31.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Ank_5 PF13857.6 EFO61240.1 - 5.8e-12 45.6 6.7 0.0012 19.1 0.2 4.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61240.1 - 7.6e-10 38.2 6.4 2.1 9.2 0.0 7.1 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.30 EFO61240.1 - 1.4e-08 34.8 10.1 0.32 11.5 0.1 6.2 5 1 0 5 5 5 3 Ankyrin repeat NAD_binding_1 PF00175.21 EFO61241.1 - 5.8e-10 39.8 0.0 1.5e-09 38.5 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EFO61241.1 - 1.7e-08 34.7 0.0 3.5e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Globin PF00042.22 EFO61241.1 - 5.1e-05 23.8 0.2 0.015 15.8 0.0 3.1 3 0 0 3 3 3 1 Globin Protoglobin PF11563.8 EFO61241.1 - 0.015 15.2 0.4 0.13 12.1 0.4 2.1 1 1 0 1 1 1 0 Protoglobin NAD_binding_6 PF08030.12 EFO61241.1 - 0.035 14.2 0.0 0.063 13.4 0.0 1.3 1 0 0 1 1 1 0 Ferric reductase NAD binding domain VSP PF03302.13 EFO61243.1 - 2.5e-93 313.1 176.5 1.6e-50 172.1 28.7 5.9 1 1 4 5 5 5 4 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO61243.1 - 0.18 11.9 0.0 0.18 11.9 0.0 2.5 3 1 1 4 4 4 0 Podoplanin Pkinase PF00069.25 EFO61245.1 - 3.5e-47 161.0 0.4 5.3e-47 160.4 0.4 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61245.1 - 6.8e-33 114.0 0.1 1e-32 113.4 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFO61245.1 - 7.7e-06 24.9 0.3 7.7e-06 24.9 0.3 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EFO61245.1 - 0.011 15.1 0.1 0.032 13.5 0.0 1.7 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 EFO61245.1 - 0.037 13.4 0.1 0.071 12.4 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Gag_p30 PF02093.16 EFO61247.1 - 0.047 13.2 0.6 0.068 12.7 0.6 1.4 1 0 0 1 1 1 0 Gag P30 core shell protein GAS PF13851.6 EFO61247.1 - 0.12 11.8 23.9 0.75 9.1 12.2 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding UPF0242 PF06785.11 EFO61247.1 - 0.16 12.0 20.4 1.7 8.7 19.1 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Fib_alpha PF08702.10 EFO61247.1 - 0.21 11.7 8.8 0.83 9.8 3.3 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF1640 PF07798.11 EFO61247.1 - 3.6 7.6 18.7 3.6 7.6 9.8 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1640) Vps51 PF08700.11 EFO61247.1 - 3.8 7.7 8.5 15 5.7 0.1 3.4 2 2 1 3 3 3 0 Vps51/Vps67 PUF PF00806.19 EFO61249.1 - 2.8e-15 55.1 5.0 0.00091 18.8 0.0 5.3 5 0 0 5 5 5 4 Pumilio-family RNA binding repeat Nup160 PF11715.8 EFO61250.1 - 0.0011 17.7 0.1 0.0071 15.0 0.1 2.0 1 1 1 2 2 2 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EFO61250.1 - 0.002 18.4 0.0 0.028 14.7 0.0 2.8 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFO61250.1 - 0.0022 18.8 8.1 0.013 16.4 0.1 3.9 4 0 0 4 4 4 1 WD domain, G-beta repeat zf-MIZ PF02891.20 EFO61252.1 - 2.4e-16 59.2 2.4 4.9e-16 58.2 2.4 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EFO61252.1 - 3.1e-05 23.7 1.6 7.5e-05 22.5 1.6 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit DUF3819 PF12842.7 EFO61252.1 - 0.12 12.4 0.1 0.58 10.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3819) Cyclin_N PF00134.23 EFO61253.1 - 0.0002 21.1 0.9 0.00028 20.7 0.9 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain CCD48 PF15799.5 EFO61253.1 - 0.073 11.4 0.0 0.089 11.1 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 VSP PF03302.13 EFO61255.1 - 1.6e-37 129.4 215.8 1.4e-27 96.6 45.9 8.7 1 1 6 7 7 7 4 Giardia variant-specific surface protein YebO PF13974.6 EFO61255.1 - 0.31 11.1 0.8 0.47 10.6 0.8 1.2 1 0 0 1 1 1 0 YebO-like protein DUF384 PF04064.13 EFO61256.1 - 7.6e-05 22.5 0.1 0.00015 21.5 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF384) FSAP_sig_propep PF03032.15 EFO61258.1 - 0.021 14.9 0.1 0.03 14.4 0.1 1.3 1 0 0 1 1 1 0 Frog skin active peptide family signal and propeptide LST1 PF05083.13 EFO61258.1 - 0.08 13.2 0.3 0.11 12.8 0.3 1.3 1 0 0 1 1 1 0 LST-1 protein Orthoreo_P10 PF07204.11 EFO61258.1 - 0.11 12.4 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 DUF4713 PF15831.5 EFO61258.1 - 0.39 11.2 3.9 0.59 10.6 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) DS PF01916.17 EFO61259.1 - 1.1e-119 399.0 0.0 1.4e-119 398.7 0.0 1.1 1 0 0 1 1 1 1 Deoxyhypusine synthase Actin PF00022.19 EFO61260.1 - 2.1e-16 59.5 0.0 2.3e-11 43.0 0.0 2.0 2 0 0 2 2 2 2 Actin MreB_Mbl PF06723.13 EFO61260.1 - 0.0004 19.3 0.0 0.00058 18.8 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein PilM_2 PF11104.8 EFO61260.1 - 0.018 14.1 0.1 0.027 13.5 0.1 1.2 1 0 0 1 1 1 0 Type IV pilus assembly protein PilM; MIF PF01187.18 EFO61262.1 - 0.023 15.0 0.0 0.038 14.3 0.0 1.4 1 1 0 1 1 1 0 Macrophage migration inhibitory factor (MIF) eIF-5_eIF-2B PF01873.17 EFO61263.1 - 4.9e-25 87.7 0.0 1.1e-24 86.5 0.0 1.6 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EFO61263.1 - 9.3e-08 32.1 1.0 2.1e-07 30.9 1.0 1.7 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon DUF2318 PF10080.9 EFO61263.1 - 0.056 13.6 0.2 0.1 12.7 0.2 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) zf-NADH-PPase PF09297.11 EFO61263.1 - 0.19 11.4 0.0 0.19 11.4 0.0 1.7 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Ribosomal_L18 PF17135.4 EFO61264.1 - 2.4e-61 206.4 0.7 2.8e-61 206.2 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EFO61264.1 - 2.9e-05 24.7 0.1 0.00017 22.2 0.1 2.2 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A WD40 PF00400.32 EFO61267.1 - 3.6e-26 90.9 22.9 5.7e-08 33.3 0.1 7.3 7 1 0 7 7 7 5 WD domain, G-beta repeat COPI_C PF06957.11 EFO61267.1 - 2.5e-18 66.1 5.9 2.7e-18 65.9 3.1 2.0 2 0 0 2 2 2 1 Coatomer (COPI) alpha subunit C-terminus Coatomer_WDAD PF04053.14 EFO61267.1 - 2.2e-08 33.6 0.5 5.3e-07 29.0 0.5 2.4 1 1 0 1 1 1 1 Coatomer WD associated region ANAPC4_WD40 PF12894.7 EFO61267.1 - 9.5e-07 29.0 0.5 0.37 11.1 0.0 4.8 2 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFO61267.1 - 0.092 12.6 0.0 13 5.6 0.0 2.6 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A ParBc_2 PF08857.11 EFO61267.1 - 0.17 12.0 0.0 0.52 10.4 0.0 1.8 2 0 0 2 2 2 0 Putative ParB-like nuclease CodY PF06018.14 EFO61270.1 - 0.045 13.2 0.1 0.21 11.1 0.0 2.0 2 0 0 2 2 2 0 CodY GAF-like domain CSTF2_hinge PF14327.6 EFO61272.1 - 0.0083 16.6 0.0 0.032 14.7 0.0 1.8 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 Ank_2 PF12796.7 EFO61275.1 - 3.3e-54 181.4 3.0 6.2e-13 49.1 0.0 5.3 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61275.1 - 2.3e-38 130.1 0.3 3.4e-08 33.9 0.0 7.0 5 2 2 7 7 7 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO61275.1 - 8.8e-34 115.1 5.0 1.7e-06 28.2 0.0 8.3 1 1 8 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61275.1 - 3.7e-31 103.7 0.1 0.0014 18.9 0.0 9.5 9 0 0 9 9 9 7 Ankyrin repeat Ank PF00023.30 EFO61275.1 - 7.5e-28 95.7 0.8 0.0099 16.3 0.0 9.5 9 0 0 9 9 9 6 Ankyrin repeat Pkinase PF00069.25 EFO61275.1 - 1.1e-20 74.1 0.0 2.3e-20 73.1 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61275.1 - 3.4e-12 46.2 0.0 5.4e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase TIR-like PF10137.9 EFO61275.1 - 0.039 13.9 0.0 0.082 12.9 0.0 1.5 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain APH PF01636.23 EFO61275.1 - 0.051 13.5 0.0 0.14 12.0 0.0 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EFO61275.1 - 0.094 12.0 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Kinase-like cNMP_binding PF00027.29 EFO61275.1 - 0.12 12.5 0.1 0.68 10.0 0.0 2.3 1 1 1 2 2 2 0 Cyclic nucleotide-binding domain Ank_2 PF12796.7 EFO61276.1 - 7.1e-13 49.0 2.1 3.4e-06 27.6 0.3 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61276.1 - 1.6e-07 31.4 0.7 0.024 15.0 0.1 3.3 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61276.1 - 4.3e-07 30.3 0.4 0.0058 17.2 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61276.1 - 1.6e-06 28.0 0.1 0.1 13.2 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EFO61276.1 - 0.0015 18.9 0.1 0.21 12.1 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Peptidase_M60_C PF18630.1 EFO61276.1 - 0.059 13.5 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Peptidase M60 C-terminal domain TrmO PF01980.16 EFO61277.1 - 6.1e-12 45.8 0.0 1.1e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 tRNA-methyltransferase O SHIPPO-rpt PF07004.12 EFO61278.1 - 3.2e-76 249.0 104.5 1e-05 26.2 0.4 18.2 18 0 0 18 18 18 17 Sperm-tail PG-rich repeat Gly_rich PF12810.7 EFO61278.1 - 0.0078 16.2 15.2 0.94 9.3 1.8 4.6 3 2 2 5 5 5 3 Glycine rich protein ECR1_N PF14382.6 EFO61278.1 - 9.7 6.1 34.2 17 5.3 0.2 11.6 14 1 1 15 15 15 0 Exosome complex exonuclease RRP4 N-terminal region RNA_pol_Rpb2_6 PF00562.28 EFO61279.1 - 3.6e-115 385.1 0.0 4.7e-115 384.8 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EFO61279.1 - 3e-25 88.9 0.0 5.1e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EFO61279.1 - 1.2e-22 80.1 0.0 2.9e-22 78.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 EFO61279.1 - 1.4e-17 63.6 0.0 3.8e-17 62.2 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 EFO61279.1 - 2.2e-17 63.1 0.2 5.3e-17 61.9 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_2 PF04561.14 EFO61279.1 - 3.2e-15 56.3 0.0 5.6e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_5 PF04567.17 EFO61279.1 - 4.4e-11 43.2 0.3 1.1e-10 41.9 0.3 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Ank_2 PF12796.7 EFO61281.1 - 4.6e-54 181.0 23.4 4.9e-14 52.7 0.6 5.8 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61281.1 - 4.4e-34 116.1 21.4 0.00054 20.2 0.0 10.1 2 2 8 10 10 10 9 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61281.1 - 3.4e-32 110.4 10.5 1.9e-07 31.5 0.0 8.0 4 2 2 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61281.1 - 9.9e-30 99.3 9.4 0.0047 17.3 0.0 10.8 12 0 0 12 12 12 7 Ankyrin repeat Ank PF00023.30 EFO61281.1 - 3.6e-26 90.4 9.3 0.012 16.0 0.0 11.0 11 0 0 11 11 11 7 Ankyrin repeat Pkinase PF00069.25 EFO61281.1 - 1.1e-16 61.1 0.0 2.5e-16 59.8 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61281.1 - 3e-08 33.3 0.0 5e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase zf-RING_2 PF13639.6 EFO61282.1 - 4.7e-10 39.6 2.7 1e-09 38.6 2.7 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EFO61282.1 - 1.8e-07 31.0 1.5 3.3e-07 30.2 0.6 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 EFO61282.1 - 1.9e-07 31.3 2.7 1.9e-07 31.3 2.7 1.8 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EFO61282.1 - 2.3e-07 30.5 0.7 6.5e-07 29.0 0.7 1.9 1 1 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 EFO61282.1 - 8.1e-07 28.8 1.9 1.9e-06 27.6 1.9 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFO61282.1 - 1.1e-05 25.2 5.7 3.6e-05 23.5 5.7 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO61282.1 - 0.00037 20.3 2.3 0.00078 19.3 2.3 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFO61282.1 - 0.00041 20.3 2.2 0.00088 19.2 2.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3H2C3 PF17122.5 EFO61282.1 - 0.00056 19.9 1.2 0.0017 18.4 1.2 1.8 1 0 0 1 1 1 1 Zinc-finger zf-Nse PF11789.8 EFO61282.1 - 0.00067 19.4 0.3 0.0039 17.0 0.3 2.1 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.7 EFO61282.1 - 0.0021 18.1 0.9 0.0064 16.5 0.9 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EFO61282.1 - 0.0044 16.6 0.4 0.0044 16.6 0.4 1.6 2 0 0 2 2 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 EFO61282.1 - 0.0079 16.0 1.6 0.019 14.8 1.6 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 EFO61282.1 - 0.054 13.7 1.7 0.15 12.3 1.7 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 EFO61282.1 - 0.3 11.2 4.4 0.89 9.7 4.5 1.8 1 1 0 1 1 1 0 RING-variant domain zf-RING-like PF08746.11 EFO61282.1 - 0.33 11.3 1.6 0.78 10.1 1.6 1.6 1 0 0 1 1 1 0 RING-like domain Myb_DNA-binding PF00249.31 EFO61283.1 - 0.00074 19.7 0.3 0.0014 18.8 0.3 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Ran-binding PF05508.11 EFO61284.1 - 0.025 13.6 0.0 1.2 8.0 0.1 2.2 2 0 0 2 2 2 0 RanGTP-binding protein DUF4735 PF15882.5 EFO61285.1 - 0.014 14.9 0.1 0.04 13.4 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4735) ApoLp-III PF07464.11 EFO61285.1 - 0.29 11.2 2.2 63 3.6 0.1 3.7 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) TetR PF13972.6 EFO61285.1 - 0.3 10.8 1.8 0.55 9.9 0.2 2.3 2 0 0 2 2 2 0 Bacterial transcriptional repressor AIP3 PF03915.13 EFO61285.1 - 0.98 8.4 7.4 0.067 12.3 2.0 1.7 2 0 0 2 2 2 0 Actin interacting protein 3 APG6_N PF17675.1 EFO61285.1 - 2.2 8.8 7.0 0.93 10.0 2.9 2.4 2 0 0 2 2 2 0 Apg6 coiled-coil region Carbpep_Y_N PF05388.11 EFO61285.1 - 2.6 8.6 6.6 1.6 9.3 0.4 3.4 3 1 0 3 3 3 0 Carboxypeptidase Y pro-peptide SHIPPO-rpt PF07004.12 EFO61287.1 - 1.8e-29 101.3 20.3 5.2e-06 27.1 0.3 6.4 6 1 0 6 6 6 6 Sperm-tail PG-rich repeat ECR1_N PF14382.6 EFO61287.1 - 0.0019 17.9 2.4 7.6 6.4 0.0 4.2 5 0 0 5 5 5 2 Exosome complex exonuclease RRP4 N-terminal region PNP_UDP_1 PF01048.20 EFO61288.1 - 5.6e-25 88.0 0.0 7.8e-24 84.2 0.0 2.1 2 0 0 2 2 2 1 Phosphorylase superfamily SafA PF17073.5 EFO61288.1 - 0.045 13.7 0.3 2 8.4 0.0 2.5 2 0 0 2 2 2 0 Two-component-system connector protein DEAD PF00270.29 EFO61289.1 - 5.6e-17 62.1 0.1 1.3e-16 60.9 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO61289.1 - 1.5e-09 38.2 0.0 3.7e-09 36.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFO61289.1 - 7.7e-06 26.0 0.0 1.3e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RecQ_Zn_bind PF16124.5 EFO61289.1 - 0.0008 20.1 0.4 0.0033 18.1 0.4 2.1 1 0 0 1 1 1 1 RecQ zinc-binding Toxin_21 PF08091.11 EFO61290.1 - 0.32 11.0 6.3 1.6 8.7 0.1 3.1 3 0 0 3 3 3 0 Spider insecticidal peptide Ost4 PF10215.9 EFO61290.1 - 0.55 10.1 4.6 5.6 6.9 0.0 3.0 3 0 0 3 3 3 0 Oligosaccaryltransferase DUF1484 PF07363.11 EFO61291.1 - 0.9 10.6 10.7 0.083 13.9 2.2 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1484) Pkinase PF00069.25 EFO61292.1 - 3.9e-20 72.3 1.0 4.6e-12 45.9 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain zf-C3HC4_3 PF13920.6 EFO61292.1 - 1.2e-10 41.1 16.5 2.4e-10 40.1 16.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Pkinase_Tyr PF07714.17 EFO61292.1 - 1.5e-07 31.0 0.0 8e-06 25.3 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase Prok-RING_4 PF14447.6 EFO61292.1 - 3.2e-07 30.1 13.7 6.6e-07 29.1 13.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 AAA_13 PF13166.6 EFO61292.1 - 0.0015 17.3 3.8 0.002 16.9 3.8 1.1 1 0 0 1 1 1 1 AAA domain SH3BP5 PF05276.14 EFO61292.1 - 0.031 14.1 4.5 0.05 13.4 4.5 1.3 1 0 0 1 1 1 0 SH3 domain-binding protein 5 (SH3BP5) Med4 PF10018.9 EFO61292.1 - 0.061 13.0 5.1 0.1 12.3 5.1 1.3 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 FapA PF03961.13 EFO61292.1 - 0.091 11.4 4.7 0.13 10.8 4.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Fib_alpha PF08702.10 EFO61292.1 - 0.16 12.2 11.7 0.09 13.0 9.4 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family ApoLp-III PF07464.11 EFO61292.1 - 0.22 11.6 8.4 0.53 10.4 8.4 1.6 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Spc7 PF08317.11 EFO61292.1 - 0.23 10.3 9.1 0.54 9.1 9.1 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein Cnn_1N PF07989.11 EFO61292.1 - 0.24 11.6 6.9 0.11 12.6 0.9 2.4 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Fez1 PF06818.15 EFO61292.1 - 0.31 11.5 8.0 0.47 10.9 8.0 1.2 1 0 0 1 1 1 0 Fez1 PHF5 PF03660.14 EFO61292.1 - 0.32 11.2 8.8 0.7 10.1 8.8 1.5 1 0 0 1 1 1 0 PHF5-like protein Bacillus_HBL PF05791.11 EFO61292.1 - 0.32 10.8 5.7 0.62 9.9 5.6 1.6 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Syntaxin-6_N PF09177.11 EFO61292.1 - 1.3 9.6 8.2 0.27 11.8 3.1 2.3 2 0 0 2 2 2 0 Syntaxin 6, N-terminal COG2 PF06148.11 EFO61292.1 - 7.2 6.7 8.7 3.3 7.8 4.5 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Nup188 PF10487.9 EFO61293.1 - 0.044 11.7 0.1 0.06 11.2 0.1 1.1 1 0 0 1 1 1 0 Nucleoporin subcomplex protein binding to Pom34 zf-RING_5 PF14634.6 EFO61294.1 - 2.6e-07 30.5 6.8 5.1e-07 29.6 6.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFO61294.1 - 9.3e-05 22.4 3.4 9.3e-05 22.4 3.4 1.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EFO61294.1 - 9.7e-05 22.6 6.6 0.0002 21.6 6.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFO61294.1 - 0.0037 17.1 3.5 0.012 15.5 3.6 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prominin PF05478.11 EFO61294.1 - 0.0042 15.1 0.7 0.048 11.6 0.0 2.2 1 1 1 2 2 2 1 Prominin zf-C3HC4_3 PF13920.6 EFO61294.1 - 0.0072 16.2 7.0 0.03 14.2 7.0 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFO61294.1 - 0.034 14.0 3.1 0.034 14.0 3.1 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO61294.1 - 0.046 13.6 9.5 0.79 9.6 10.2 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 DUF4709 PF15821.5 EFO61294.1 - 0.17 12.2 3.0 3.1 8.1 0.1 3.3 2 1 2 4 4 4 0 Domain of unknown function (DUF4709) zf-HC5HC2H PF13771.6 EFO61294.1 - 0.6 10.4 4.9 1.3 9.3 4.9 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain FYVE PF01363.21 EFO61294.1 - 1.1 9.5 5.5 3.7 7.8 5.5 1.9 1 1 0 1 1 1 0 FYVE zinc finger zf-RING_4 PF14570.6 EFO61294.1 - 7 6.5 8.0 53 3.7 8.7 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Ribosomal_L22e PF01776.17 EFO61295.1 - 7.1e-23 81.1 0.5 8.7e-23 80.8 0.5 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family DHHC PF01529.20 EFO61296.1 - 1e-15 58.0 12.7 1e-15 58.0 12.7 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase Transpos_assoc PF13963.6 EFO61297.1 - 0.74 10.2 2.6 24 5.3 2.6 2.5 1 1 0 1 1 1 0 Transposase-associated domain DUF3792 PF12670.7 EFO61299.1 - 0.026 14.7 0.6 0.094 12.9 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) DUF2108 PF09881.9 EFO61299.1 - 0.1 12.6 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2108) VSP PF03302.13 EFO61300.1 - 2.1e-29 102.6 193.3 1.6e-20 73.4 80.4 7.3 1 1 2 3 3 3 3 Giardia variant-specific surface protein Nuf2 PF03800.14 EFO61302.1 - 1.6e-11 44.5 0.8 4.6e-11 43.0 0.0 2.3 2 1 0 2 2 2 1 Nuf2 family Taxilin PF09728.9 EFO61302.1 - 0.015 14.5 22.8 0.024 13.8 12.0 2.5 2 0 0 2 2 2 0 Myosin-like coiled-coil protein DUF3584 PF12128.8 EFO61302.1 - 0.03 11.9 26.0 0.26 8.7 8.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) APG6_N PF17675.1 EFO61302.1 - 0.034 14.7 30.2 0.53 10.8 7.7 3.3 1 1 3 4 4 4 0 Apg6 coiled-coil region DUF4407 PF14362.6 EFO61302.1 - 0.1 11.9 25.0 0.27 10.5 11.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Rab5-bind PF09311.11 EFO61302.1 - 0.13 11.7 25.9 0.82 9.0 9.9 2.7 1 1 0 2 2 2 0 Rabaptin-like protein YabA PF06156.13 EFO61302.1 - 0.13 12.9 22.1 0.72 10.5 2.5 4.2 1 1 2 3 3 3 0 Initiation control protein YabA HALZ PF02183.18 EFO61302.1 - 0.18 12.0 0.2 0.18 12.0 0.2 4.6 4 1 0 4 4 4 0 Homeobox associated leucine zipper CENP-H PF05837.12 EFO61302.1 - 0.38 11.2 23.9 0.29 11.6 1.7 3.5 2 1 1 3 3 3 0 Centromere protein H (CENP-H) Tup_N PF08581.10 EFO61302.1 - 0.61 10.4 22.1 1.9 8.9 2.6 5.2 2 2 3 5 5 5 0 Tup N-terminal Prominin PF05478.11 EFO61302.1 - 0.69 7.8 24.4 0.049 11.6 3.9 2.2 1 1 1 2 2 2 0 Prominin Sec34 PF04136.15 EFO61302.1 - 0.92 9.4 20.0 0.55 10.1 2.9 4.6 1 1 2 4 4 4 0 Sec34-like family DUF4472 PF14739.6 EFO61302.1 - 1.1 10.0 22.7 0.13 13.0 4.8 3.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) Fib_alpha PF08702.10 EFO61302.1 - 1.2 9.3 26.3 0.2 11.8 8.0 3.6 1 1 0 3 3 3 0 Fibrinogen alpha/beta chain family CC2-LZ PF16516.5 EFO61302.1 - 1.5 9.2 21.5 0.64 10.4 3.5 4.3 2 1 2 4 4 4 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Spc7 PF08317.11 EFO61302.1 - 2.2 7.1 30.5 40 2.9 18.8 3.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DASH_Duo1 PF08651.10 EFO61302.1 - 2.9 7.7 12.2 0.32 10.8 0.6 4.3 4 0 0 4 4 4 0 DASH complex subunit Duo1 HrpB7 PF09486.10 EFO61302.1 - 4.6 7.6 18.4 13 6.1 4.2 3.4 1 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) Jnk-SapK_ap_N PF09744.9 EFO61302.1 - 5.7 7.1 25.2 2 8.6 4.4 3.6 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 DUF2203 PF09969.9 EFO61302.1 - 6 7.6 16.5 9.5 7.0 1.1 3.9 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) MRPL52 PF18699.1 EFO61302.1 - 7.5 6.8 17.6 0.12 12.6 3.6 3.8 2 1 3 5 5 5 0 Mitoribosomal protein mL52 BRE1 PF08647.11 EFO61302.1 - 9.1 6.4 23.9 6.9 6.8 1.0 4.6 2 2 2 4 4 4 0 BRE1 E3 ubiquitin ligase Uso1_p115_C PF04871.13 EFO61302.1 - 9.3 6.6 24.6 2.4 8.6 3.5 3.7 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region HR_lesion PF05514.11 EFO61303.1 - 0.073 13.3 3.0 13 6.0 0.2 3.2 3 0 0 3 3 3 0 HR-like lesion-inducing T4BSS_DotI_IcmL PF11393.8 EFO61304.1 - 0.018 14.5 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 Type-IV b secretion system, inner-membrane complex component DUF2682 PF10909.8 EFO61304.1 - 0.054 14.0 1.6 0.054 14.0 1.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2682) HWE_HK PF07536.14 EFO61304.1 - 0.07 13.8 0.1 0.098 13.4 0.1 1.2 1 0 0 1 1 1 0 HWE histidine kinase LPP PF04728.13 EFO61304.1 - 0.14 12.6 0.6 4 7.9 0.5 2.3 2 0 0 2 2 2 0 Lipoprotein leucine-zipper UCH PF00443.29 EFO61305.1 - 5.5e-30 104.7 0.1 9.8e-30 103.9 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFO61305.1 - 2.7e-13 50.2 3.5 1.1e-09 38.3 0.3 2.3 1 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Copine PF07002.16 EFO61306.1 - 1.9e-26 92.9 0.1 4e-26 91.8 0.1 1.6 1 1 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 EFO61306.1 - 1.2e-10 41.8 0.4 2.2e-10 41.0 0.4 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 EFO61306.1 - 0.00038 20.8 0.2 0.00067 19.9 0.2 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain ATG16 PF08614.11 EFO61307.1 - 0.00056 20.2 15.6 0.00056 20.2 15.6 2.5 3 0 0 3 3 3 1 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 EFO61307.1 - 0.014 15.4 2.4 0.014 15.4 2.4 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) IFT57 PF10498.9 EFO61307.1 - 0.015 14.2 7.0 0.024 13.6 7.0 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF948 PF06103.11 EFO61307.1 - 0.041 14.1 0.7 0.041 14.1 0.7 3.7 1 1 3 4 4 4 0 Bacterial protein of unknown function (DUF948) Taxilin PF09728.9 EFO61307.1 - 0.087 12.0 11.0 0.15 11.2 0.0 2.3 2 1 0 2 2 2 0 Myosin-like coiled-coil protein Laminin_II PF06009.12 EFO61307.1 - 0.11 12.5 13.5 1.1 9.3 6.0 2.8 1 1 0 2 2 2 0 Laminin Domain II NPV_P10 PF05531.12 EFO61307.1 - 0.12 12.9 11.2 11 6.6 0.2 4.2 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein LPP PF04728.13 EFO61307.1 - 0.12 12.7 7.7 0.14 12.6 0.9 3.2 2 1 1 3 3 2 0 Lipoprotein leucine-zipper Lebercilin PF15619.6 EFO61307.1 - 0.21 11.2 17.0 0.057 13.1 8.8 2.7 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease FtsQ PF03799.15 EFO61307.1 - 0.24 12.2 0.8 0.6 10.9 0.1 2.0 2 0 0 2 2 2 0 Cell division protein FtsQ GAS PF13851.6 EFO61307.1 - 0.31 10.4 9.5 3 7.1 9.2 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF16 PF01519.16 EFO61307.1 - 0.35 11.4 6.5 0.17 12.4 1.7 2.7 1 1 1 2 2 2 0 Protein of unknown function DUF16 FH2 PF02181.23 EFO61307.1 - 0.35 9.9 9.8 0.57 9.2 0.7 2.2 1 1 1 2 2 2 0 Formin Homology 2 Domain Mer2 PF09074.10 EFO61307.1 - 0.58 9.9 12.2 0.68 9.7 9.3 2.1 1 1 1 2 2 2 0 Mer2 Spc7 PF08317.11 EFO61307.1 - 0.58 9.0 17.1 0.16 10.8 13.2 1.9 2 1 0 2 2 2 0 Spc7 kinetochore protein PI3K_P85_iSH2 PF16454.5 EFO61307.1 - 0.59 9.7 6.2 0.23 11.0 2.3 2.1 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Serine_rich PF08824.10 EFO61307.1 - 0.59 10.1 9.4 4.1 7.4 2.4 2.7 1 1 0 2 2 2 0 Serine rich protein interaction domain Prominin PF05478.11 EFO61307.1 - 0.65 7.9 13.4 1.3 6.9 13.4 1.4 1 1 0 1 1 1 0 Prominin EzrA PF06160.12 EFO61307.1 - 0.74 7.9 15.0 1.4 7.1 7.5 2.2 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Snapin_Pallidin PF14712.6 EFO61307.1 - 0.86 10.1 16.2 4 7.9 5.8 2.5 1 1 1 2 2 2 0 Snapin/Pallidin BLOC1_2 PF10046.9 EFO61307.1 - 0.86 9.9 11.6 3.4 8.0 0.4 3.4 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CorA PF01544.18 EFO61307.1 - 0.89 8.8 11.0 1.6 8.0 9.3 2.1 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein zf-CpG_bind_C PF12269.8 EFO61307.1 - 0.91 9.3 5.4 1 9.1 0.4 2.4 1 1 1 2 2 2 0 CpG binding protein zinc finger C terminal domain DUF2408 PF10303.9 EFO61307.1 - 1.2 9.7 12.3 6 7.4 2.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) MCPsignal PF00015.21 EFO61307.1 - 2.7 7.8 14.6 3.4 7.5 7.6 2.9 1 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain ISG65-75 PF11727.8 EFO61307.1 - 3.2 6.9 7.2 1.3 8.2 3.7 1.9 1 1 0 2 2 2 0 Invariant surface glycoprotein DivIVA PF05103.13 EFO61307.1 - 4.2 7.5 14.7 0.26 11.4 6.9 2.5 1 1 1 2 2 2 0 DivIVA protein SKA1 PF07160.12 EFO61307.1 - 5.1 6.9 9.1 3.8 7.3 6.3 2.0 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 Mce4_CUP1 PF11887.8 EFO61307.1 - 6.6 6.1 6.6 2 7.8 1.4 2.2 1 1 2 3 3 3 0 Cholesterol uptake porter CUP1 of Mce4, putative DUF948 PF06103.11 EFO61308.1 - 0.92 9.8 3.0 2.5 8.4 3.0 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Ank_2 PF12796.7 EFO61309.1 - 3.7e-135 440.8 63.2 2.8e-13 50.2 0.0 15.6 4 3 12 16 16 16 16 Ankyrin repeats (3 copies) Ank PF00023.30 EFO61309.1 - 8.4e-70 228.4 60.4 1.1e-05 25.6 0.1 24.2 23 1 1 24 24 24 19 Ankyrin repeat Ank_5 PF13857.6 EFO61309.1 - 5.1e-69 227.4 58.9 2.6e-05 24.4 0.1 22.3 8 6 16 24 24 24 19 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61309.1 - 1e-67 223.6 54.1 1.3e-07 32.0 0.1 21.0 11 8 14 25 25 25 21 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61309.1 - 8.6e-56 179.3 58.6 0.023 15.2 0.1 27.7 30 0 0 30 30 30 16 Ankyrin repeat Pkinase PF00069.25 EFO61309.1 - 4.3e-19 68.9 0.0 1.4e-18 67.2 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61309.1 - 2.9e-09 36.6 0.0 9.4e-09 34.9 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Attractin PF08037.11 EFO61309.1 - 0.2 11.7 2.3 0.71 9.9 0.7 2.5 2 0 0 2 2 2 0 Attractin family Macro PF01661.21 EFO61311.1 - 1.3e-06 28.4 0.1 4.6e-06 26.7 0.0 1.9 2 1 0 2 2 2 1 Macro domain ATP-synt_C PF00137.21 EFO61312.1 - 1.2e-32 112.0 31.1 1.9e-21 76.1 13.2 2.1 2 0 0 2 2 2 2 ATP synthase subunit C FapA PF03961.13 EFO61315.1 - 0.0013 17.4 5.3 0.0013 17.4 5.3 8.3 5 2 2 8 8 8 4 Flagellar Assembly Protein A GAS PF13851.6 EFO61315.1 - 0.0039 16.6 9.6 0.0039 16.6 9.6 9.4 9 1 0 10 10 10 4 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 EFO61315.1 - 0.0042 17.6 7.4 0.0042 17.6 7.4 11.1 8 3 4 12 12 12 6 Apg6 coiled-coil region KASH_CCD PF14662.6 EFO61315.1 - 0.0043 16.9 4.2 0.0043 16.9 4.2 10.3 7 3 1 9 9 9 4 Coiled-coil region of CCDC155 or KASH BRE1 PF08647.11 EFO61315.1 - 0.0054 16.8 11.1 0.0054 16.8 11.1 12.2 11 4 2 14 14 14 2 BRE1 E3 ubiquitin ligase HNH PF01844.23 EFO61315.1 - 5.4 7.3 5.2 4.7 7.5 0.3 2.8 2 0 0 2 2 2 0 HNH endonuclease Yip1 PF04893.17 EFO61316.1 - 0.0023 17.7 11.3 0.0031 17.2 11.3 1.2 1 0 0 1 1 1 1 Yip1 domain Pkinase PF00069.25 EFO61317.1 - 1.2e-38 133.0 0.0 1.6e-38 132.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61317.1 - 9.3e-27 93.9 0.0 1.2e-26 93.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO61317.1 - 0.13 11.6 0.0 0.29 10.4 0.0 1.6 1 1 0 1 1 1 0 Kinase-like Pkinase PF00069.25 EFO61318.1 - 7.3e-33 114.0 0.0 2.8e-32 112.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61318.1 - 3.8e-19 69.0 0.0 5.2e-19 68.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase AMP-binding PF00501.28 EFO61319.1 - 2.1e-76 257.2 0.1 8.9e-57 192.6 0.1 2.1 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 EFO61319.1 - 0.0012 19.7 0.0 0.0038 18.2 0.0 1.9 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain tRNA-synt_1d PF00750.19 EFO61320.1 - 3.1e-114 381.6 0.2 7.7e-114 380.3 0.1 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EFO61320.1 - 1.9e-24 86.1 0.0 5.1e-24 84.7 0.0 1.8 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EFO61320.1 - 7.6e-05 23.2 0.0 0.00029 21.4 0.0 1.9 1 1 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.19 EFO61320.1 - 0.046 13.0 0.1 0.08 12.3 0.1 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EFO61320.1 - 0.13 10.9 0.9 2.2 6.9 0.1 2.7 3 0 0 3 3 3 0 tRNA synthetases class I (M) SHIPPO-rpt PF07004.12 EFO61321.1 - 1.9e-23 82.2 53.4 4.3e-05 24.2 0.6 6.6 6 1 0 6 6 6 6 Sperm-tail PG-rich repeat SHIPPO-rpt PF07004.12 EFO61322.1 - 9.9e-15 54.7 36.1 0.017 16.0 0.0 8.2 8 0 0 8 8 8 7 Sperm-tail PG-rich repeat TPR_1 PF00515.28 EFO61327.1 - 2.2e-14 52.5 3.9 0.018 14.8 0.0 8.2 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFO61327.1 - 1.3e-13 50.0 1.7 0.25 11.6 0.0 8.0 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFO61327.1 - 3e-13 48.8 17.3 0.033 14.3 0.0 9.0 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_16 PF13432.6 EFO61327.1 - 4.8e-09 36.7 0.9 0.019 15.6 0.0 5.5 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFO61327.1 - 5.6e-08 33.0 10.3 0.1 13.4 0.0 7.6 4 3 5 9 9 9 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFO61327.1 - 7.8e-08 32.4 11.5 0.097 12.9 0.3 5.0 2 1 2 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EFO61327.1 - 8.8e-08 32.6 10.3 0.0051 17.3 0.5 6.4 4 3 4 8 8 8 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFO61327.1 - 3.6e-07 29.7 0.2 0.21 11.3 0.0 5.3 5 1 1 6 6 6 2 TPR repeat TPR_9 PF13371.6 EFO61327.1 - 2e-06 27.8 7.0 0.078 13.1 0.0 4.8 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFO61327.1 - 1.6e-05 25.1 14.6 1.1 9.6 0.4 6.3 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EFO61327.1 - 0.00038 19.9 1.4 0.39 10.0 0.1 3.4 2 1 1 3 3 3 1 MalT-like TPR region TPR_6 PF13174.6 EFO61327.1 - 0.0024 18.4 7.5 2.1 9.1 0.0 6.3 7 0 0 7 7 7 1 Tetratricopeptide repeat ZnuA PF01297.17 EFO61327.1 - 0.042 13.3 1.0 2.3 7.6 0.0 2.2 2 0 0 2 2 2 0 Zinc-uptake complex component A periplasmic TPR_17 PF13431.6 EFO61327.1 - 0.53 10.8 4.9 14 6.4 0.0 4.9 6 0 0 6 6 4 0 Tetratricopeptide repeat ATP-synt_C PF00137.21 EFO61328.1 - 5.5e-29 100.3 35.1 8.1e-21 74.1 17.9 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Ank_2 PF12796.7 EFO61330.1 - 1.2e-36 125.2 12.2 4.1e-09 36.9 0.1 6.9 5 2 2 7 7 7 6 Ankyrin repeats (3 copies) Ank PF00023.30 EFO61330.1 - 2.8e-16 59.1 1.0 0.012 16.0 0.0 8.8 8 1 0 8 8 8 2 Ankyrin repeat Ank_5 PF13857.6 EFO61330.1 - 4.3e-15 55.6 5.7 0.0082 16.4 0.1 8.2 5 2 4 9 9 9 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61330.1 - 2.7e-14 51.8 5.9 0.034 14.7 0.0 9.5 10 0 0 10 10 10 3 Ankyrin repeat Ank_4 PF13637.6 EFO61330.1 - 1.1e-13 51.4 6.9 0.0022 18.5 0.0 8.0 5 3 5 10 10 10 2 Ankyrin repeats (many copies) BRE1 PF08647.11 EFO61330.1 - 2.3 8.4 20.2 0.44 10.7 5.5 4.0 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase Jnk-SapK_ap_N PF09744.9 EFO61330.1 - 3.3 7.9 17.3 4.2 7.6 8.0 2.6 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 TPR_MLP1_2 PF07926.12 EFO61330.1 - 8.6 6.4 24.9 1.9 8.6 3.5 3.1 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein SMC_N PF02463.19 EFO61331.1 - 5.9e-72 241.7 0.0 2.3e-71 239.8 0.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EFO61331.1 - 4.3e-18 65.7 0.0 1.1e-17 64.5 0.0 1.7 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EFO61331.1 - 3.4e-10 40.2 0.3 0.00041 20.3 0.0 2.9 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFO61331.1 - 2.6e-06 27.4 15.9 6.3e-05 22.8 0.0 4.7 4 1 0 4 4 4 1 AAA ATPase domain AAA_23 PF13476.6 EFO61331.1 - 2.8e-06 28.0 8.8 2.8e-06 28.0 8.8 5.8 4 2 1 5 5 4 1 AAA domain AAA_29 PF13555.6 EFO61331.1 - 8.7e-06 25.4 0.0 2e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.6 EFO61331.1 - 0.00016 20.5 6.7 0.00016 20.5 6.7 4.8 6 0 0 6 6 6 2 AAA domain MscS_porin PF12795.7 EFO61331.1 - 0.0033 17.0 32.5 0.0033 17.0 32.5 5.5 4 1 1 5 5 4 2 Mechanosensitive ion channel porin domain AAA_27 PF13514.6 EFO61331.1 - 0.012 15.3 2.7 4 7.0 0.0 3.5 2 0 0 2 2 2 0 AAA domain Spc7 PF08317.11 EFO61331.1 - 0.075 11.9 72.7 0.0093 14.9 7.9 6.2 4 2 2 6 6 6 0 Spc7 kinetochore protein T2SSG PF08334.11 EFO61331.1 - 0.088 12.9 0.5 0.77 9.9 0.0 2.5 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein G ABC_tran PF00005.27 EFO61331.1 - 0.22 12.0 7.3 4.1 7.9 0.0 4.8 2 1 0 2 2 2 0 ABC transporter DASH_Dad1 PF08649.10 EFO61331.1 - 2.5 8.3 4.7 1.9 8.8 0.2 3.2 3 0 0 3 3 3 0 DASH complex subunit Dad1 Vip3A_N PF12495.8 EFO61331.1 - 3.4 7.5 5.5 1.1 9.1 0.0 3.0 4 0 0 4 4 4 0 Vegetative insecticide protein 3A N terminal DUF4407 PF14362.6 EFO61331.1 - 7.9 5.7 52.3 1.8 7.8 5.0 6.0 4 2 1 5 5 5 0 Domain of unknown function (DUF4407) AAA_9 PF12781.7 EFO61332.1 - 1.8e-81 272.5 8.3 1.7e-79 266.0 7.8 3.0 2 1 0 2 2 2 1 ATP-binding dynein motor region Dynein_heavy PF03028.15 EFO61332.1 - 8.7e-40 135.5 0.0 1.6e-34 118.5 0.0 2.7 2 0 0 2 2 2 2 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 EFO61332.1 - 2.6e-11 43.6 0.0 6.2e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Med7 PF05983.11 EFO61332.1 - 0.1 12.7 0.7 0.25 11.4 0.7 1.6 1 0 0 1 1 1 0 MED7 protein AAA_6 PF12774.7 EFO61332.1 - 0.13 11.2 0.2 0.25 10.3 0.2 1.5 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region Fibrillarin PF01269.17 EFO61333.1 - 5.6e-101 336.4 0.0 6.5e-101 336.2 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EFO61333.1 - 4.9e-07 29.7 0.0 7.3e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 EFO61333.1 - 0.0097 15.7 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltr_RsmB-F PF01189.17 EFO61333.1 - 0.15 11.7 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EFO61333.1 - 0.15 12.1 0.0 0.21 11.7 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase V-SNARE_C PF12352.8 EFO61334.1 - 0.00024 21.3 0.7 0.0005 20.3 0.7 1.5 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus ING PF12998.7 EFO61334.1 - 0.044 14.4 1.9 0.068 13.8 1.9 1.2 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding Sec20 PF03908.13 EFO61334.1 - 0.089 12.7 1.7 0.23 11.4 0.2 2.0 1 1 1 2 2 2 0 Sec20 GvpK PF05121.12 EFO61334.1 - 1.7 8.7 7.2 0.68 10.0 0.6 2.4 2 0 0 2 2 2 0 Gas vesicle protein K VSP PF03302.13 EFO61335.1 - 2.3e-28 99.2 127.4 4.5e-14 52.1 39.2 5.8 1 1 4 5 5 5 5 Giardia variant-specific surface protein Cnd2 PF05786.14 EFO61336.1 - 1e-18 67.5 0.4 9.4e-15 54.3 0.0 2.2 2 0 0 2 2 2 2 Condensin complex subunit 2 CNDH2_N PF06278.11 EFO61336.1 - 0.0065 16.7 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Ribosomal_S25 PF03297.15 EFO61336.1 - 0.24 11.6 1.6 0.26 11.5 0.0 1.8 2 0 0 2 2 2 0 S25 ribosomal protein HEAT PF02985.22 EFO61337.1 - 0.0068 16.6 0.0 8.2 7.0 0.0 3.0 2 0 0 2 2 2 2 HEAT repeat ABC_tran PF00005.27 EFO61338.1 - 1.9e-41 141.8 0.0 5.6e-24 85.2 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 EFO61338.1 - 3.6e-23 82.3 49.2 1.2e-14 54.2 19.3 3.2 3 0 0 3 3 3 2 ABC-2 family transporter protein AAA_21 PF13304.6 EFO61338.1 - 1.6e-13 51.1 6.8 4.6e-06 26.7 0.0 3.8 3 1 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFO61338.1 - 8.9e-08 31.8 0.3 0.06 12.8 0.0 3.3 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFO61338.1 - 3e-05 23.7 0.3 0.00013 21.7 0.0 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EFO61338.1 - 0.00011 22.8 0.0 0.00025 21.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 EFO61338.1 - 0.00027 20.9 0.3 0.15 12.0 0.2 2.8 2 0 0 2 2 2 1 Rad17 P-loop domain RsgA_GTPase PF03193.16 EFO61338.1 - 0.0007 19.5 2.3 0.0055 16.6 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EFO61338.1 - 0.0025 17.9 1.8 0.0033 17.5 0.2 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_15 PF13175.6 EFO61338.1 - 0.012 15.3 0.0 0.54 9.9 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain MukB PF04310.12 EFO61338.1 - 0.019 14.8 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 MukB N-terminal DUF87 PF01935.17 EFO61338.1 - 0.075 13.1 0.1 7.3 6.6 0.0 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_27 PF13514.6 EFO61338.1 - 0.077 12.6 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Archease PF01951.16 EFO61338.1 - 0.091 13.0 0.0 0.28 11.4 0.0 1.8 1 0 0 1 1 1 0 Archease protein family (MTH1598/TM1083) Dynamin_N PF00350.23 EFO61338.1 - 0.15 12.1 0.0 0.34 10.9 0.0 1.6 1 0 0 1 1 1 0 Dynamin family SWIRM PF04433.17 EFO61340.1 - 5.8e-12 45.8 0.2 2.3e-11 43.9 0.2 2.1 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_2 PF16496.5 EFO61340.1 - 1.6e-07 30.5 0.0 0.035 13.0 0.0 3.7 3 1 0 3 3 3 2 SWIRM-associated domain at the N-terminal DivIVA PF05103.13 EFO61341.1 - 0.033 14.3 0.1 0.064 13.3 0.1 1.5 1 0 0 1 1 1 0 DivIVA protein GTP_EFTU PF00009.27 EFO61342.1 - 3.6e-43 147.4 0.0 7e-43 146.4 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFO61342.1 - 4.4e-15 56.0 0.4 1.1e-13 51.4 0.0 3.1 3 1 0 3 3 3 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 EFO61342.1 - 0.00017 21.6 0.0 0.00064 19.8 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EFO61342.1 - 0.00036 20.9 0.1 0.0011 19.3 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 EFO61342.1 - 0.0007 19.5 0.0 0.14 12.0 0.0 2.4 1 1 1 2 2 2 2 RsgA GTPase KTI12 PF08433.10 EFO61342.1 - 0.021 14.3 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Gtr1_RagA PF04670.12 EFO61342.1 - 0.049 13.0 0.0 0.18 11.1 0.0 1.9 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF243 PF03103.17 EFO61342.1 - 0.055 13.8 0.0 5.6 7.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF243) G-alpha PF00503.20 EFO61342.1 - 0.061 12.5 0.0 0.33 10.1 0.0 2.0 1 1 0 1 1 1 0 G-protein alpha subunit Ank_2 PF12796.7 EFO61344.1 - 7.8e-46 154.6 12.5 1.3e-12 48.2 0.4 5.4 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO61344.1 - 3.5e-32 111.8 0.0 6e-32 111.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 EFO61344.1 - 4.4e-26 90.9 8.9 1.1e-05 25.9 0.0 6.1 3 1 3 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61344.1 - 5.2e-26 87.9 8.8 0.047 14.3 0.0 10.2 10 0 0 10 10 10 7 Ankyrin repeat Ank_5 PF13857.6 EFO61344.1 - 1.1e-25 89.3 9.3 5.5e-05 23.4 0.1 7.3 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO61344.1 - 3.1e-21 75.8 0.0 5.9e-21 74.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Ank PF00023.30 EFO61344.1 - 2e-18 65.9 10.8 0.25 11.9 0.1 9.7 10 1 0 10 10 10 6 Ankyrin repeat Fructosamin_kin PF03881.14 EFO61344.1 - 0.016 14.4 0.0 0.027 13.7 0.0 1.3 1 0 0 1 1 1 0 Fructosamine kinase DivIC PF04977.15 EFO61344.1 - 0.027 14.2 0.0 0.071 12.9 0.0 1.7 1 0 0 1 1 1 0 Septum formation initiator WD40 PF00400.32 EFO61345.1 - 2.7e-09 37.5 1.1 0.00088 20.0 0.0 4.4 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO61345.1 - 3.2e-06 27.3 0.0 0.21 11.9 0.0 3.3 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain NIF PF03031.18 EFO61346.1 - 4.1e-36 124.1 0.0 6.5e-36 123.5 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase RTC PF01137.21 EFO61347.1 - 0.51 9.5 2.1 1.7 7.8 0.2 2.1 2 0 0 2 2 2 0 RNA 3'-terminal phosphate cyclase Cation_ATPase_C PF00689.21 EFO61348.1 - 1.1e-35 122.9 8.2 1.1e-35 122.9 8.2 2.9 4 0 0 4 4 4 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFO61348.1 - 1e-19 70.8 3.5 1e-19 70.8 3.5 3.5 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase_N PF00690.26 EFO61348.1 - 7.2e-11 41.6 0.0 2.2e-10 40.1 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase_C PF00689.21 EFO61349.1 - 1.4e-42 145.4 3.5 1.4e-42 145.4 3.5 2.6 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFO61349.1 - 2.7e-40 137.8 1.3 2.7e-40 137.8 1.3 3.0 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EFO61349.1 - 1.7e-18 67.7 0.6 2e-17 64.2 0.6 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFO61349.1 - 2.9e-18 65.3 0.0 1e-17 63.6 0.0 2.0 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EFO61349.1 - 1.7e-15 56.9 0.0 3.9e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFO61349.1 - 2.9e-05 23.9 0.6 9.9e-05 22.2 0.2 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFO61349.1 - 0.003 18.0 0.0 0.0059 17.0 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Wzy_C PF04932.15 EFO61349.1 - 0.11 12.1 10.5 0.23 11.1 0.1 3.9 3 1 0 3 3 3 0 O-Antigen ligase DUF4231 PF14015.6 EFO61349.1 - 1.6 9.2 9.2 1.1 9.7 0.3 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) TMEM208_SND2 PF05620.11 EFO61349.1 - 3.6 7.3 7.1 8.9 6.1 0.8 2.9 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 NUDIX PF00293.28 EFO61350.1 - 5e-09 36.3 0.0 2.5e-08 34.1 0.0 2.3 2 1 0 2 2 2 1 NUDIX domain Helicase_C PF00271.31 EFO61351.1 - 1.2e-12 48.1 0.1 7.5e-12 45.6 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HA2 PF04408.23 EFO61351.1 - 1.2e-10 41.6 0.1 4.8e-10 39.7 0.1 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFO61351.1 - 2.5e-09 37.4 0.0 5.9e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Adaptin_N PF01602.20 EFO61352.1 - 1.4e-78 264.7 0.1 2.1e-78 264.2 0.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EFO61352.1 - 1.2e-28 100.2 2.4 1.5e-28 99.9 0.2 2.4 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFO61352.1 - 1.1e-10 41.7 8.8 1.2e-05 25.6 0.5 6.3 6 1 1 7 7 7 3 HEAT repeats HEAT PF02985.22 EFO61352.1 - 3.5e-07 29.9 3.7 0.048 13.9 0.0 5.5 5 0 0 5 5 5 2 HEAT repeat Vitellogenin_N PF01347.22 EFO61352.1 - 0.064 11.7 0.5 0.25 9.7 0.1 1.9 1 1 1 2 2 2 0 Lipoprotein amino terminal region HEAT_EZ PF13513.6 EFO61352.1 - 0.072 13.6 1.9 7.3 7.2 0.1 4.0 3 0 0 3 3 3 0 HEAT-like repeat Lin-8 PF03353.15 EFO61352.1 - 0.24 10.9 0.1 0.58 9.7 0.0 1.6 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist ASFV_J13L PF05568.11 EFO61352.1 - 0.31 10.8 11.4 0.71 9.6 11.4 1.6 1 0 0 1 1 1 0 African swine fever virus J13L protein Arm PF00514.23 EFO61352.1 - 0.51 10.5 2.4 2.4 8.3 0.4 3.4 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Gcd10p PF04189.13 EFO61353.1 - 6.9e-12 45.1 0.0 2.1e-10 40.2 0.0 2.0 2 0 0 2 2 2 2 Gcd10p family Kinesin PF00225.23 EFO61354.1 - 1.3e-08 34.2 0.0 1.6e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFO61354.1 - 0.00022 21.2 0.0 0.00051 20.0 0.0 1.6 2 0 0 2 2 2 1 Microtubule binding dNK PF01712.19 EFO61357.1 - 2.9e-53 180.8 1.3 3.5e-53 180.5 1.3 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.6 EFO61357.1 - 2.5e-12 47.5 0.0 3.8e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFO61357.1 - 1.6e-06 28.3 0.0 6.3e-06 26.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EFO61357.1 - 6.1e-06 26.7 0.1 0.0038 17.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.17 EFO61357.1 - 7.7e-05 22.4 0.1 0.032 13.9 0.0 2.3 2 0 0 2 2 2 2 Thymidylate kinase AAA_28 PF13521.6 EFO61357.1 - 0.00012 22.4 0.0 0.00017 21.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain SKI PF01202.22 EFO61357.1 - 0.00012 22.2 0.1 0.3 11.2 0.0 2.9 2 1 0 2 2 2 2 Shikimate kinase Cytidylate_kin2 PF13189.6 EFO61357.1 - 0.00019 21.6 0.0 0.00058 20.0 0.0 1.8 1 0 0 1 1 1 1 Cytidylate kinase-like family TsaE PF02367.17 EFO61357.1 - 0.001 19.0 0.1 0.0066 16.4 0.0 2.2 2 1 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE PPK2 PF03976.14 EFO61357.1 - 0.0026 17.3 0.6 0.0051 16.3 0.1 1.6 2 0 0 2 2 2 1 Polyphosphate kinase 2 (PPK2) NB-ARC PF00931.22 EFO61357.1 - 0.0051 16.0 0.1 0.036 13.2 0.1 2.0 1 1 0 1 1 1 1 NB-ARC domain AAA PF00004.29 EFO61357.1 - 0.0095 16.4 0.0 0.019 15.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EFO61357.1 - 0.03 13.6 0.0 0.11 11.8 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.6 EFO61357.1 - 0.039 14.2 0.0 0.21 11.9 0.0 2.1 2 1 0 2 2 2 0 AAA domain ADK PF00406.22 EFO61357.1 - 0.078 13.1 0.3 4.4 7.4 0.1 2.2 2 0 0 2 2 2 0 Adenylate kinase PPR_2 PF13041.6 EFO61357.1 - 0.087 13.0 2.1 18 5.6 0.1 3.9 4 0 0 4 4 4 0 PPR repeat family AAA_16 PF13191.6 EFO61357.1 - 0.11 12.8 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain CoaE PF01121.20 EFO61357.1 - 0.17 11.6 0.0 0.56 9.8 0.0 1.8 2 0 0 2 2 2 0 Dephospho-CoA kinase cobW PF02492.19 EFO61357.1 - 0.2 11.3 0.1 0.36 10.4 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Ank_2 PF12796.7 EFO61358.1 - 2.6e-23 82.4 0.0 1.1e-11 45.2 0.0 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO61358.1 - 1.5e-15 55.7 0.0 0.00071 19.9 0.0 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EFO61358.1 - 2e-14 53.4 0.1 0.00056 20.2 0.0 4.3 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61358.1 - 7.7e-14 51.9 0.2 6e-07 29.9 0.0 4.4 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO61358.1 - 2.1e-12 46.9 0.0 0.013 15.9 0.0 4.8 5 0 0 5 5 5 3 Ankyrin repeat zinc_ribbon_15 PF17032.5 EFO61358.1 - 0.17 12.7 0.1 0.3 11.9 0.1 1.4 1 0 0 1 1 1 0 zinc-ribbon family Pkinase PF00069.25 EFO61359.1 - 1.4e-30 106.6 0.0 1.7e-30 106.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61359.1 - 8.1e-20 71.2 0.0 9.4e-20 71.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFO61359.1 - 0.0015 18.5 0.2 0.0036 17.3 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFO61359.1 - 0.016 14.5 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Ank_2 PF12796.7 EFO61360.1 - 2.2e-95 313.4 21.3 2.4e-14 53.7 0.1 11.4 2 2 7 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61360.1 - 5.6e-55 183.1 19.9 1.9e-05 25.1 0.0 16.0 13 3 5 18 18 18 12 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO61360.1 - 2.4e-52 174.3 24.9 1.9e-05 24.8 0.1 15.7 6 5 9 16 16 16 13 Ankyrin repeats (many copies) Ank PF00023.30 EFO61360.1 - 2.3e-44 148.0 23.4 0.0028 18.0 0.0 20.8 21 0 0 21 21 21 13 Ankyrin repeat Ank_3 PF13606.6 EFO61360.1 - 4.5e-43 140.3 23.7 0.014 15.9 0.0 20.4 21 0 0 21 21 21 11 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO61360.1 - 2.2e-09 37.0 18.0 4.1e-09 36.1 18.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO61360.1 - 0.0061 16.4 19.1 0.014 15.3 19.1 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 GHMP_kinases_N PF00288.26 EFO61362.1 - 1.1e-09 38.4 0.2 2.6e-09 37.2 0.2 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EFO61362.1 - 3.4e-07 30.5 0.2 1.3e-06 28.7 0.2 2.0 1 1 1 2 2 2 1 GHMP kinases C terminal S4 PF01479.25 EFO61362.1 - 0.032 14.0 0.2 0.085 12.6 0.1 1.8 2 0 0 2 2 2 0 S4 domain DUF2802 PF10975.8 EFO61362.1 - 0.069 13.3 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2802) AAA_23 PF13476.6 EFO61363.1 - 1.9 8.9 5.7 3.2 8.2 5.7 1.2 1 0 0 1 1 1 0 AAA domain Acetyltransf_1 PF00583.25 EFO61364.1 - 9.3e-15 54.9 0.0 1.3e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFO61364.1 - 2.9e-10 40.2 0.0 2.5e-09 37.1 0.1 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFO61364.1 - 2.8e-08 34.0 0.0 5.4e-08 33.1 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EFO61364.1 - 7.3e-05 22.9 0.1 0.00017 21.7 0.2 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFO61364.1 - 8.9e-05 22.4 0.0 0.00013 21.8 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EFO61364.1 - 0.00025 21.1 0.1 0.025 14.6 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Ank_2 PF12796.7 EFO61365.1 - 3.1e-49 165.5 6.5 1.5e-14 54.3 0.0 6.5 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO61365.1 - 5.2e-43 147.3 0.0 1.1e-42 146.2 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 EFO61365.1 - 7.7e-29 99.7 7.3 1.2e-06 28.9 0.2 8.4 6 3 2 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61365.1 - 1.6e-28 95.5 6.2 0.0074 16.7 0.0 11.3 11 0 0 11 11 11 7 Ankyrin repeat Pkinase_Tyr PF07714.17 EFO61365.1 - 1.4e-27 96.6 0.0 4.4e-27 95.0 0.0 1.8 1 1 1 2 2 2 1 Protein tyrosine kinase Ank PF00023.30 EFO61365.1 - 8.1e-27 92.5 10.6 0.054 14.0 0.0 9.9 9 2 2 11 11 10 8 Ankyrin repeat Ank_5 PF13857.6 EFO61365.1 - 5.7e-26 90.2 8.3 5.1e-05 23.5 0.0 8.8 3 3 6 9 9 9 7 Ankyrin repeats (many copies) ATG16 PF08614.11 EFO61365.1 - 0.00035 20.9 64.9 0.19 11.9 13.5 4.3 1 1 3 4 4 4 3 Autophagy protein 16 (ATG16) UPF0242 PF06785.11 EFO61365.1 - 0.0022 18.2 19.3 0.0022 18.2 19.3 4.2 1 1 3 4 4 4 2 Uncharacterised protein family (UPF0242) N-terminus BRE1 PF08647.11 EFO61365.1 - 0.0046 17.0 9.4 0.0046 17.0 9.4 5.3 2 1 2 5 5 4 2 BRE1 E3 ubiquitin ligase APG6_N PF17675.1 EFO61365.1 - 0.013 16.0 16.8 0.013 16.0 16.8 5.1 1 1 4 5 5 5 0 Apg6 coiled-coil region Fez1 PF06818.15 EFO61365.1 - 0.94 9.9 52.6 0.65 10.4 12.4 3.3 1 1 2 3 3 3 0 Fez1 GAS PF13851.6 EFO61365.1 - 1.9 7.8 61.6 0.27 10.6 19.9 4.3 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding Sulfatase PF00884.23 EFO61366.1 - 1.5e-14 54.1 0.0 2.3e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EFO61366.1 - 0.008 15.8 0.0 0.04 13.5 0.0 1.9 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Collectrin PF16959.5 EFO61366.1 - 0.014 15.1 3.4 0.04 13.7 3.4 1.7 1 0 0 1 1 1 0 Renal amino acid transporter DUF1678 PF07913.11 EFO61366.1 - 0.086 12.6 0.1 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1678) Ins134_P3_kin PF05770.11 EFO61367.1 - 0.00018 21.1 0.0 0.0022 17.5 0.0 2.3 2 0 0 2 2 2 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain zf-C3HC4_3 PF13920.6 EFO61368.1 - 6.8e-13 48.3 15.2 1e-12 47.7 15.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO61368.1 - 1.5e-06 27.9 14.3 2.8e-06 27.1 14.3 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Arrestin_C PF02752.22 EFO61368.1 - 0.00027 21.4 0.1 0.0071 16.8 0.1 2.5 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain zf-RING_2 PF13639.6 EFO61368.1 - 0.0034 17.7 17.1 0.0059 16.9 17.1 1.4 1 0 0 1 1 1 1 Ring finger domain Arrestin_N PF00339.29 EFO61368.1 - 0.011 15.8 0.0 0.031 14.3 0.0 1.7 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain zf-RING_5 PF14634.6 EFO61368.1 - 0.11 12.5 14.9 0.19 11.7 14.9 1.4 1 0 0 1 1 1 0 zinc-RING finger domain LCAT PF02450.15 EFO61369.1 - 1e-15 57.9 0.0 2.8e-15 56.4 0.0 1.7 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase PGAP1 PF07819.13 EFO61369.1 - 2.2e-05 24.3 0.0 0.00015 21.6 0.0 2.1 2 0 0 2 2 2 1 PGAP1-like protein Abhydrolase_1 PF00561.20 EFO61369.1 - 4.3e-05 23.3 0.4 8.7e-05 22.3 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFO61369.1 - 0.00038 19.8 0.0 0.00073 18.9 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFO61369.1 - 0.00097 19.8 0.0 0.0019 18.8 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.11 EFO61369.1 - 0.00097 18.5 0.0 0.003 17.0 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Palm_thioest PF02089.15 EFO61369.1 - 0.012 15.4 0.0 0.051 13.4 0.0 1.9 2 0 0 2 2 2 0 Palmitoyl protein thioesterase Peptidase_S9 PF00326.21 EFO61369.1 - 0.2 11.1 0.0 0.37 10.2 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family WD40 PF00400.32 EFO61370.1 - 4.4e-06 27.3 6.4 0.45 11.5 0.2 4.5 5 0 0 5 5 5 3 WD domain, G-beta repeat Yippee-Mis18 PF03226.14 EFO61371.1 - 0.059 13.6 0.2 0.1 12.8 0.2 1.4 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly LSM PF01423.22 EFO61372.1 - 3.4e-05 23.5 0.0 4.2e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 LSM domain DUF3247 PF11607.8 EFO61372.1 - 0.045 14.0 0.0 0.057 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3247) EGF_2 PF07974.13 EFO61373.1 - 3.6e-05 24.0 254.3 0.0013 19.1 3.8 23.2 22 0 0 22 22 22 16 EGF-like domain hEGF PF12661.7 EFO61373.1 - 0.0036 17.9 7.3 0.0036 17.9 7.3 22.7 22 0 0 22 22 22 7 Human growth factor-like EGF Isochorismatase PF00857.20 EFO61374.1 - 1.4e-29 103.5 0.0 1.6e-29 103.3 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family Bromodomain PF00439.25 EFO61376.1 - 0.00023 21.2 0.1 0.0056 16.7 0.0 2.6 2 0 0 2 2 2 1 Bromodomain WH2 PF02205.20 EFO61376.1 - 0.042 13.7 0.3 2 8.4 0.1 2.4 2 0 0 2 2 2 0 WH2 motif SNAP PF14938.6 EFO61378.1 - 1.5e-50 172.2 18.0 1.8e-50 171.9 18.0 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_MalT PF17874.1 EFO61378.1 - 2.6e-06 27.1 0.7 0.0033 16.8 0.6 2.3 1 1 1 2 2 2 2 MalT-like TPR region TPR_12 PF13424.6 EFO61378.1 - 3.9e-06 27.1 7.6 0.015 15.6 0.1 3.4 2 1 2 4 4 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFO61378.1 - 6e-05 23.5 1.4 1 10.4 0.0 4.2 3 1 2 5 5 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFO61378.1 - 0.00014 21.7 1.7 1.3 9.2 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFO61378.1 - 0.0022 18.0 10.7 1.1 9.5 0.3 5.0 2 1 3 5 5 5 1 Tetratricopeptide repeat USP8_dimer PF08969.11 EFO61378.1 - 0.0028 17.8 2.2 0.0028 17.8 2.2 3.1 3 1 1 4 4 4 1 USP8 dimerisation domain MIT PF04212.18 EFO61378.1 - 0.015 15.3 2.1 0.015 15.3 2.1 4.5 3 1 2 5 5 5 0 MIT (microtubule interacting and transport) domain TOM20_plant PF06552.12 EFO61378.1 - 0.03 14.1 0.7 0.055 13.2 0.4 1.6 1 1 0 1 1 1 0 Plant specific mitochondrial import receptor subunit TOM20 DUF357 PF04010.13 EFO61378.1 - 0.033 14.3 4.5 0.069 13.2 0.3 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF357) TPR_1 PF00515.28 EFO61378.1 - 0.045 13.6 10.9 12 5.9 0.3 4.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFO61378.1 - 0.096 13.3 2.4 4 8.2 0.1 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat HrpF PF06266.12 EFO61378.1 - 0.1 12.9 0.1 0.34 11.2 0.1 1.9 1 0 0 1 1 1 0 HrpF protein NSF PF02071.20 EFO61378.1 - 0.16 12.8 17.9 0.39 11.6 0.8 5.1 5 0 0 5 5 4 0 Aromatic-di-Alanine (AdAR) repeat SRP_TPR_like PF17004.5 EFO61378.1 - 0.24 11.4 7.6 1.3 9.1 0.7 2.7 1 1 2 3 3 3 0 Putative TPR-like repeat TPR_6 PF13174.6 EFO61378.1 - 0.34 11.6 8.2 21 6.0 0.1 4.8 2 1 3 5 5 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFO61378.1 - 0.37 11.1 16.2 7.6 7.0 1.0 4.7 3 1 2 5 5 5 0 Tetratricopeptide repeat HHH_8 PF14716.6 EFO61378.1 - 0.78 10.2 4.4 24 5.4 0.0 3.7 2 2 0 2 2 2 0 Helix-hairpin-helix domain HEAT PF02985.22 EFO61379.1 - 5.4e-10 38.7 1.0 0.0075 16.4 0.0 5.3 4 0 0 4 4 4 3 HEAT repeat HEAT_EZ PF13513.6 EFO61379.1 - 5.2e-07 30.0 0.0 0.00026 21.4 0.0 3.8 2 1 1 3 3 3 2 HEAT-like repeat DRIM PF07539.12 EFO61379.1 - 6.5e-06 24.8 1.4 0.017 13.5 0.0 4.5 5 1 0 5 5 5 2 Down-regulated in metastasis Importin_rep_4 PF18808.1 EFO61379.1 - 9.1e-05 22.7 0.0 0.0013 19.0 0.0 3.0 2 0 0 2 2 2 1 Importin repeat HEAT_2 PF13646.6 EFO61379.1 - 0.00034 20.9 0.0 0.014 15.8 0.0 3.0 2 0 0 2 2 2 1 HEAT repeats UNC45-central PF11701.8 EFO61379.1 - 0.27 11.2 7.9 2 8.4 0.4 5.2 5 2 1 6 6 6 0 Myosin-binding striated muscle assembly central SoxE PF06525.11 EFO61380.1 - 0.071 12.6 0.9 4.2 6.9 0.1 2.3 2 0 0 2 2 2 0 Sulfocyanin (SoxE) domain RhoGAP PF00620.27 EFO61384.1 - 1.4e-11 44.5 0.1 1.8e-11 44.1 0.1 1.1 1 0 0 1 1 1 1 RhoGAP domain TC1 PF15063.6 EFO61384.1 - 0.036 13.9 0.1 0.077 12.9 0.1 1.5 2 0 0 2 2 2 0 Thyroid cancer protein 1 Viral_alk_exo PF01771.17 EFO61384.1 - 0.063 12.1 0.0 0.076 11.9 0.0 1.1 1 0 0 1 1 1 0 Viral alkaline exonuclease RNA_pol_A_bac PF01000.26 EFO61385.1 - 4.8e-21 75.2 0.0 1.5e-20 73.6 0.0 1.8 2 1 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EFO61385.1 - 3.4e-12 45.6 0.0 4.7e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Annexin PF00191.20 EFO61386.1 - 1.1e-13 51.0 0.6 8.4e-05 22.6 0.0 4.3 5 0 0 5 5 5 3 Annexin Sec1 PF00995.23 EFO61387.1 - 8.7e-20 71.5 3.9 1.2e-19 71.0 3.9 1.1 1 0 0 1 1 1 1 Sec1 family Pur_ac_phosph_N PF16656.5 EFO61388.1 - 9.4e-06 26.1 0.4 1.8e-05 25.2 0.4 1.4 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Ank_2 PF12796.7 EFO61390.1 - 1.5e-77 256.2 0.7 1e-15 58.0 0.0 6.0 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61390.1 - 7.1e-38 128.5 3.3 2.8e-06 27.7 0.0 8.6 8 2 1 9 9 9 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO61390.1 - 8.3e-34 114.6 1.1 0.00045 20.5 0.0 9.4 9 1 1 10 10 10 6 Ankyrin repeat Ank_5 PF13857.6 EFO61390.1 - 1.2e-28 98.7 7.8 2.1e-05 24.7 0.0 7.9 3 2 4 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61390.1 - 4.1e-26 88.2 1.5 0.017 15.6 0.0 9.0 8 2 1 9 9 9 7 Ankyrin repeat Phage_T7_Capsid PF05396.11 EFO61390.1 - 0.052 13.9 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 Phage T7 capsid assembly protein DUF3881 PF12997.7 EFO61390.1 - 0.27 10.4 0.5 1.6 7.9 0.2 2.3 3 0 0 3 3 3 0 Domain of unknown function, E. rectale Gene description (DUF3881) VSP PF03302.13 EFO61391.1 - 1.6e-64 218.2 83.3 6.2e-37 127.4 30.9 3.0 2 1 1 3 3 3 3 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO61391.1 - 0.0073 16.4 1.4 0.0079 16.3 0.1 1.8 2 0 0 2 2 2 1 Podoplanin Jnk-SapK_ap_N PF09744.9 EFO61392.1 - 0.0065 16.7 7.8 0.0065 16.7 7.8 3.1 2 1 0 2 2 1 1 JNK_SAPK-associated protein-1 ZnuA PF01297.17 EFO61392.1 - 0.025 14.0 0.4 0.025 14.0 0.4 2.0 2 0 0 2 2 2 0 Zinc-uptake complex component A periplasmic PKcGMP_CC PF16808.5 EFO61392.1 - 0.034 14.0 14.7 0.25 11.2 0.8 4.3 5 0 0 5 5 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase NAP PF00956.18 EFO61392.1 - 0.26 10.4 7.6 0.16 11.2 2.5 2.7 3 0 0 3 3 3 0 Nucleosome assembly protein (NAP) Baculo_PEP_C PF04513.12 EFO61392.1 - 0.84 9.7 5.0 2.5 8.1 0.1 3.2 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus UPF0242 PF06785.11 EFO61392.1 - 1.6 8.8 19.3 0.13 12.3 7.7 3.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus CENP-F_leu_zip PF10473.9 EFO61392.1 - 1.6 8.7 26.3 0.69 9.9 11.8 3.5 3 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Mt_ATP-synt_B PF05405.14 EFO61392.1 - 2.1 8.0 9.4 0.29 10.8 3.7 2.3 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) CdvA PF18822.1 EFO61392.1 - 2.1 8.2 20.6 1 9.2 0.2 4.0 3 1 1 4 4 4 0 CdvA-like coiled-coil domain TMF_TATA_bd PF12325.8 EFO61392.1 - 2.5 8.3 25.9 1.3 9.2 0.8 3.4 2 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Vps51 PF08700.11 EFO61392.1 - 3.1 7.9 14.8 2.6 8.2 5.9 3.5 3 1 0 3 3 3 0 Vps51/Vps67 CorA PF01544.18 EFO61392.1 - 5 6.4 9.8 6.1 6.1 1.0 2.6 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF641 PF04859.12 EFO61392.1 - 7.5 6.9 19.0 3.8 7.8 6.7 3.3 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) Vma12 PF11712.8 EFO61393.1 - 0.44 10.6 6.3 1.1 9.3 4.2 2.4 2 1 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Cyclin PF08613.11 EFO61394.1 - 6.3e-14 52.7 0.5 1.1e-13 51.9 0.5 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EFO61394.1 - 2.6e-05 24.0 0.6 5.4e-05 22.9 0.5 1.5 1 1 0 1 1 1 1 Cyclin, N-terminal domain DUF2153 PF09921.9 EFO61394.1 - 0.047 13.5 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2153) Ribosomal_L50 PF10501.9 EFO61394.1 - 0.084 13.0 0.0 0.64 10.2 0.0 2.3 2 0 0 2 2 2 0 Ribosomal subunit 39S DnaJ_C PF01556.18 EFO61396.1 - 1.7e-30 106.0 0.0 3.4e-30 105.1 0.0 1.5 2 0 0 2 2 2 1 DnaJ C terminal domain DnaJ PF00226.31 EFO61396.1 - 2.3e-20 72.4 0.8 4.1e-20 71.7 0.8 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EFO61396.1 - 2e-12 47.3 10.4 4.6e-12 46.1 10.4 1.7 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 EFO61396.1 - 0.0021 18.0 2.9 0.5 10.4 0.1 2.4 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Anti-TRAP PF15777.5 EFO61396.1 - 0.58 10.2 11.4 5 7.2 3.0 3.4 1 1 3 4 4 4 0 Tryptophan RNA-binding attenuator protein inhibitory protein Lar_restr_allev PF14354.6 EFO61396.1 - 1.9 8.9 7.8 3.1 8.3 3.0 2.7 2 0 0 2 2 2 0 Restriction alleviation protein Lar Nbl1_Borealin_N PF10444.9 EFO61397.1 - 0.0052 16.4 4.2 0.025 14.2 0.6 3.0 2 0 0 2 2 2 1 Nbl1 / Borealin N terminal Pkinase PF00069.25 EFO61398.1 - 2.9e-59 200.6 0.1 7.1e-57 192.8 0.1 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61398.1 - 2.5e-26 92.5 0.0 1e-25 90.5 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFO61398.1 - 0.0099 14.7 0.0 0.014 14.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EFO61398.1 - 0.019 14.0 1.6 0.035 13.1 0.2 1.9 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase FTA2 PF13095.6 EFO61398.1 - 0.022 14.4 0.0 3 7.4 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 S4 PF01479.25 EFO61399.1 - 0.0027 17.4 1.0 0.0046 16.7 0.2 1.8 2 0 0 2 2 2 1 S4 domain Med31 PF05669.12 EFO61400.1 - 1.1e-22 79.8 7.3 1.2e-22 79.7 6.9 1.3 1 1 0 1 1 1 1 SOH1 Copine PF07002.16 EFO61401.1 - 5.6e-48 163.3 0.0 7e-48 163.0 0.0 1.1 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 EFO61401.1 - 1.1e-10 42.0 0.1 1.9e-10 41.2 0.1 1.4 1 1 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 EFO61401.1 - 0.0075 16.5 0.0 0.016 15.4 0.0 1.7 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFO61401.1 - 0.025 15.2 0.0 0.22 12.2 0.0 2.3 1 1 1 2 2 2 0 von Willebrand factor type A domain Colicin_V PF02674.16 EFO61402.1 - 0.097 12.6 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 Colicin V production protein SPC22 PF04573.12 EFO61403.1 - 6.9e-25 87.5 1.5 8.4e-25 87.2 1.5 1.1 1 0 0 1 1 1 1 Signal peptidase subunit Sec1 PF00995.23 EFO61404.1 - 1.9e-35 123.1 0.0 2.7e-35 122.7 0.0 1.2 1 0 0 1 1 1 1 Sec1 family SPAM PF02090.15 EFO61404.1 - 0.019 14.8 0.3 0.03 14.1 0.3 1.3 1 0 0 1 1 1 0 Salmonella surface presentation of antigen gene type M protein Ribosomal_S25 PF03297.15 EFO61405.1 - 2.5e-17 62.9 2.3 2.7e-17 62.8 2.3 1.0 1 0 0 1 1 1 1 S25 ribosomal protein HTH_24 PF13412.6 EFO61405.1 - 0.00027 20.4 0.1 0.00043 19.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR PF01047.22 EFO61405.1 - 0.00054 19.8 0.1 0.0011 18.9 0.1 1.4 1 0 0 1 1 1 1 MarR family EAP30 PF04157.16 EFO61405.1 - 0.0011 18.3 0.0 0.0013 18.1 0.0 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family HTH_11 PF08279.12 EFO61405.1 - 0.0054 16.6 0.1 0.0073 16.2 0.1 1.2 1 0 0 1 1 1 1 HTH domain DAHP_synth_2 PF01474.16 EFO61405.1 - 0.0056 15.2 0.1 0.0061 15.1 0.1 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family DUF2129 PF09902.9 EFO61405.1 - 0.013 15.6 0.1 0.16 12.0 0.0 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2129) CHASE8 PF17152.4 EFO61405.1 - 0.05 13.9 0.0 0.093 13.0 0.0 1.4 1 1 0 1 1 1 0 Periplasmic sensor domain Mga PF05043.13 EFO61405.1 - 0.11 13.1 0.1 0.2 12.3 0.1 1.6 1 1 0 1 1 1 0 Mga helix-turn-helix domain MarR_2 PF12802.7 EFO61405.1 - 0.18 11.7 0.0 0.26 11.2 0.0 1.2 1 0 0 1 1 1 0 MarR family Peptidase_C1 PF00112.23 EFO61406.1 - 2.9e-29 102.7 0.9 7.5e-29 101.4 0.9 1.7 1 1 0 1 1 1 1 Papain family cysteine protease DUF508 PF04370.12 EFO61406.1 - 1.3 8.8 6.9 11 5.7 3.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF508) SR-25 PF10500.9 EFO61406.1 - 7.3 6.1 6.9 10 5.6 6.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Herpes_capsid PF06112.11 EFO61406.1 - 9.8 6.2 8.7 24 5.0 7.2 2.1 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein eIF3g PF12353.8 EFO61407.1 - 7.5e-20 71.6 2.1 1.6e-19 70.5 0.1 2.1 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit G UQ_con PF00179.26 EFO61408.1 - 3.1e-44 150.0 0.0 3.6e-44 149.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFO61408.1 - 0.14 12.5 0.1 0.21 11.9 0.1 1.4 1 1 0 1 1 1 0 RWD domain Peptidase_S28 PF05577.12 EFO61409.1 - 1.7e-60 205.1 1.2 5.2e-60 203.5 1.2 1.8 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S9 PF00326.21 EFO61409.1 - 4.8e-06 26.2 0.0 2.4e-05 23.9 0.0 2.2 3 0 0 3 3 3 1 Prolyl oligopeptidase family Acyl-CoA_dh_2 PF08028.11 EFO61410.1 - 0.015 15.6 0.4 0.025 14.9 0.4 1.3 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain Ribosomal_L11_N PF03946.14 EFO61412.1 - 7.2e-13 48.2 0.4 1.4e-12 47.2 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EFO61412.1 - 5.5e-11 42.8 0.0 8.3e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Sec23_trunk PF04811.15 EFO61413.1 - 1.3e-40 139.6 0.0 2.6e-38 132.0 0.0 2.3 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EFO61413.1 - 5.2e-15 55.1 0.2 1.1e-14 54.1 0.2 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EFO61413.1 - 1.1e-10 41.3 1.2 1.1e-10 41.3 1.2 2.1 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 EFO61413.1 - 3.2e-07 31.0 0.0 1.3e-06 29.0 0.0 2.0 1 1 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 EFO61413.1 - 5.4e-05 23.0 0.1 0.00032 20.5 0.1 2.2 1 1 0 1 1 1 1 Gelsolin repeat DUF4538 PF15061.6 EFO61414.1 - 0.1 12.4 0.1 0.2 11.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) MFS_1 PF07690.16 EFO61415.1 - 2.2e-32 112.4 37.3 6.8e-28 97.6 30.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFO61415.1 - 0.00085 18.0 32.9 0.26 9.8 14.9 2.2 1 1 1 2 2 2 2 MFS/sugar transport protein Lac_bphage_repr PF06543.12 EFO61415.1 - 0.12 12.4 0.1 0.25 11.3 0.1 1.5 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor Wzz PF02706.15 EFO61415.1 - 1.2 9.5 6.5 3.5 8.0 0.7 3.8 3 1 0 3 3 3 0 Chain length determinant protein Prenyltrans PF00432.21 EFO61417.1 - 1.5e-07 31.0 2.5 2.7e-05 23.8 0.1 5.1 6 1 0 6 6 6 3 Prenyltransferase and squalene oxidase repeat Ank_2 PF12796.7 EFO61419.1 - 1.3e-80 266.0 1.1 1.6e-14 54.2 0.0 5.6 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61419.1 - 6.4e-46 154.2 5.4 2.1e-11 44.1 0.0 6.7 6 1 1 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO61419.1 - 3e-39 131.8 0.5 0.00012 22.4 0.0 9.6 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.6 EFO61419.1 - 2.5e-37 126.4 11.7 2.2e-05 24.6 0.1 8.5 1 1 7 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61419.1 - 1.1e-32 108.3 1.4 0.0027 18.0 0.0 9.8 9 0 0 9 9 9 8 Ankyrin repeat Pkinase PF00069.25 EFO61419.1 - 1.3e-21 77.2 0.0 3.7e-21 75.7 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61419.1 - 1.8e-16 60.2 0.0 2.9e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3077 PF11275.8 EFO61419.1 - 0.09 13.0 0.9 0.21 11.8 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3077) AAA_12 PF13087.6 EFO61420.1 - 4.1e-27 95.1 0.0 1e-26 93.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain DUF2650 PF10853.8 EFO61420.1 - 0.064 13.0 0.3 0.11 12.2 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2650) UvrD_C_2 PF13538.6 EFO61420.1 - 0.088 12.6 0.0 0.28 11.0 0.0 1.9 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain WD40 PF00400.32 EFO61421.1 - 2.6e-08 34.4 10.8 0.0044 17.8 0.1 6.5 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO61421.1 - 2.1e-06 27.9 0.0 0.28 11.5 0.0 4.0 2 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Proteasome PF00227.26 EFO61422.1 - 1.1e-40 139.2 0.0 1.3e-40 139.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFO61422.1 - 3.6e-11 42.5 0.0 6.3e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature KH_8 PF17903.1 EFO61423.1 - 4.3e-22 78.0 0.0 8.7e-22 77.0 0.0 1.5 1 0 0 1 1 1 1 Krr1 KH1 domain Eno-Rase_NADH_b PF12242.8 EFO61423.1 - 0.02 14.6 0.1 0.075 12.8 0.0 1.9 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase THF_DHG_CYH_C PF02882.19 EFO61423.1 - 0.039 13.3 0.1 0.062 12.6 0.1 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF4915 PF16261.5 EFO61423.1 - 0.06 12.6 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4915) KH_1 PF00013.29 EFO61423.1 - 0.12 12.2 0.2 0.26 11.2 0.2 1.5 1 0 0 1 1 1 0 KH domain Ribosomal_L5e PF17144.4 EFO61424.1 - 6e-79 263.7 0.1 9e-79 263.2 0.1 1.3 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EFO61424.1 - 3.5e-28 98.4 4.5 3.5e-28 98.4 4.5 1.9 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Peptidase_M14 PF00246.24 EFO61425.1 - 8.2e-32 111.2 0.0 2.1e-31 109.8 0.0 1.8 1 0 0 1 1 1 1 Zinc carboxypeptidase Pepdidase_M14_N PF18027.1 EFO61425.1 - 6.5e-06 26.5 0.1 4.6e-05 23.7 0.2 2.3 2 0 0 2 2 2 1 Cytosolic carboxypeptidase N-terminal domain TAN PF11640.8 EFO61426.1 - 0.14 12.2 0.6 0.77 9.9 0.1 2.5 1 1 0 2 2 2 0 Telomere-length maintenance and DNA damage repair Prefoldin_2 PF01920.20 EFO61427.1 - 6.9e-20 71.0 9.2 8e-20 70.8 9.2 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF1241 PF06840.11 EFO61427.1 - 5e-05 23.0 0.6 0.0014 18.3 0.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF1241) Spectrin PF00435.21 EFO61427.1 - 0.00024 21.5 4.3 0.00044 20.7 4.3 1.4 1 1 0 1 1 1 1 Spectrin repeat ApoLp-III PF07464.11 EFO61427.1 - 0.00044 20.4 5.0 0.0027 17.8 3.6 2.1 1 1 1 2 2 2 1 Apolipophorin-III precursor (apoLp-III) Leu_zip PF15294.6 EFO61427.1 - 0.003 17.1 6.2 0.0032 17.0 6.2 1.0 1 0 0 1 1 1 1 Leucine zipper SlyX PF04102.12 EFO61427.1 - 0.0037 17.8 2.5 0.05 14.2 0.3 2.3 2 0 0 2 2 2 1 SlyX Sas6_CC PF18594.1 EFO61427.1 - 0.0039 16.9 4.9 0.19 11.5 0.0 3.5 3 1 1 4 4 4 1 Sas6/XLF/XRCC4 coiled-coil domain FliJ PF02050.16 EFO61427.1 - 0.011 16.0 2.9 0.87 9.8 0.2 2.1 2 0 0 2 2 2 0 Flagellar FliJ protein BLOC1_2 PF10046.9 EFO61427.1 - 0.011 16.0 4.4 0.42 10.9 0.2 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CENP-H PF05837.12 EFO61427.1 - 0.014 15.8 4.9 1.1 9.6 0.7 2.2 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Tektin PF03148.14 EFO61427.1 - 0.016 14.0 7.2 0.066 12.0 0.7 2.3 1 1 0 2 2 2 0 Tektin family CdvA PF18822.1 EFO61427.1 - 0.016 15.0 5.5 0.62 9.9 1.3 2.1 1 1 1 2 2 2 0 CdvA-like coiled-coil domain DUF1664 PF07889.12 EFO61427.1 - 0.025 14.6 4.5 0.27 11.3 0.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Uds1 PF15456.6 EFO61427.1 - 0.027 14.6 4.9 0.043 14.0 4.9 1.4 1 1 0 1 1 1 0 Up-regulated During Septation Baculo_PEP_C PF04513.12 EFO61427.1 - 0.028 14.4 0.9 0.053 13.6 0.9 1.5 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMF_DNA_bd PF12329.8 EFO61427.1 - 0.028 14.4 4.1 0.028 14.4 4.1 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Prefoldin PF02996.17 EFO61427.1 - 0.032 14.1 6.2 0.29 11.0 6.2 2.1 1 1 0 1 1 1 0 Prefoldin subunit NPV_P10 PF05531.12 EFO61427.1 - 0.033 14.6 3.3 2.6 8.5 0.5 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein WXG100 PF06013.12 EFO61427.1 - 0.036 14.3 0.7 1.5 9.1 0.1 2.3 2 0 0 2 2 2 0 Proteins of 100 residues with WXG FlxA PF14282.6 EFO61427.1 - 0.037 14.0 2.9 1.1 9.3 0.5 2.1 2 0 0 2 2 2 0 FlxA-like protein DUF5320 PF17253.2 EFO61427.1 - 0.061 14.4 2.0 7.1 7.8 0.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5320) TolA_bind_tri PF16331.5 EFO61427.1 - 0.063 13.4 5.7 2.1 8.5 0.3 2.2 2 0 0 2 2 2 0 TolA binding protein trimerisation Sec2p PF06428.11 EFO61427.1 - 0.066 13.2 7.3 1.6 8.8 1.3 2.2 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p Fib_alpha PF08702.10 EFO61427.1 - 0.072 13.3 3.6 0.082 13.1 3.6 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Spc7 PF08317.11 EFO61427.1 - 0.073 11.9 8.4 0.54 9.1 0.5 2.0 1 1 0 1 1 1 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 EFO61427.1 - 0.074 13.1 7.0 1.7 8.7 0.4 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein FPRL1_inhibitor PF16104.5 EFO61427.1 - 0.076 13.2 0.3 0.11 12.6 0.2 1.5 1 1 0 1 1 1 0 Formyl peptide receptor-like 1 inhibitory protein Nre_C PF04895.12 EFO61427.1 - 0.078 12.9 0.6 2.8 7.9 0.1 2.0 1 1 1 2 2 2 0 Archaeal Nre, C-terminal Apolipoprotein PF01442.18 EFO61427.1 - 0.084 12.7 8.0 0.36 10.7 8.0 1.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Med9 PF07544.13 EFO61427.1 - 0.1 12.7 4.4 1.1 9.4 1.2 2.2 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 ZapB PF06005.12 EFO61427.1 - 0.11 13.0 7.7 1.8 9.1 1.7 2.2 2 0 0 2 2 2 0 Cell division protein ZapB ADIP PF11559.8 EFO61427.1 - 0.12 12.5 5.1 1.7 8.7 0.6 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Csm1_N PF18504.1 EFO61427.1 - 0.13 12.6 8.5 1.7 9.0 2.7 2.3 1 1 0 2 2 2 0 Csm1 N-terminal domain THOC7 PF05615.13 EFO61427.1 - 0.13 12.6 6.0 0.22 11.8 0.6 2.1 2 0 0 2 2 2 0 Tho complex subunit 7 Prefoldin_3 PF13758.6 EFO61427.1 - 0.13 12.4 3.7 0.18 11.9 3.3 1.4 1 1 0 1 1 1 0 Prefoldin subunit COG2 PF06148.11 EFO61427.1 - 0.19 11.8 4.1 0.98 9.5 2.4 2.0 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Cauli_AT PF03233.13 EFO61427.1 - 0.25 11.3 3.1 0.35 10.8 1.3 2.0 1 1 1 2 2 2 0 Aphid transmission protein YtxH PF12732.7 EFO61427.1 - 0.3 11.7 2.6 1.2 9.8 0.5 2.1 1 1 1 2 2 2 0 YtxH-like protein Tropomyosin_1 PF12718.7 EFO61427.1 - 0.43 10.7 10.8 1 9.5 2.9 2.1 1 1 0 2 2 2 0 Tropomyosin like UPF0242 PF06785.11 EFO61427.1 - 0.45 10.6 7.9 15 5.7 8.0 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Spc24 PF08286.11 EFO61427.1 - 0.46 10.7 7.8 2.9 8.2 0.6 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF948 PF06103.11 EFO61427.1 - 0.68 10.2 4.7 28 5.1 4.7 2.2 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Seryl_tRNA_N PF02403.22 EFO61427.1 - 0.72 10.1 7.8 7.8 6.8 0.4 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Swi5 PF07061.11 EFO61427.1 - 0.83 9.8 6.8 3.6 7.7 1.3 2.3 1 1 0 2 2 2 0 Swi5 E2F_CC-MB PF16421.5 EFO61427.1 - 0.94 9.9 5.0 7.4 7.0 0.2 2.1 2 0 0 2 2 2 0 E2F transcription factor CC-MB domain DivIVA PF05103.13 EFO61427.1 - 1.1 9.4 7.4 2.1 8.4 0.9 2.1 2 0 0 2 2 2 0 DivIVA protein FlaC_arch PF05377.11 EFO61427.1 - 2.6 8.5 6.6 3.6 8.1 1.1 3.0 2 2 0 3 3 2 0 Flagella accessory protein C (FlaC) Med4 PF10018.9 EFO61427.1 - 3.7 7.2 7.7 1.1 8.9 2.3 2.0 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Ank_2 PF12796.7 EFO61428.1 - 2.7e-15 56.7 0.3 3.4e-06 27.6 0.0 3.4 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61428.1 - 1.9e-09 37.9 0.0 0.011 16.2 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61428.1 - 5.2e-09 35.6 0.4 3.1 8.7 0.0 5.8 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EFO61428.1 - 2.2e-07 31.0 0.1 1.8 9.2 0.0 5.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EFO61428.1 - 4.6e-06 26.8 0.4 0.36 11.2 0.0 4.7 3 2 1 4 4 4 2 Ankyrin repeats (many copies) tRNA_int_endo PF01974.17 EFO61431.1 - 3.9e-10 39.7 0.1 9.9e-10 38.4 0.1 1.7 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain zf-H2C2_2 PF13465.6 EFO61431.1 - 0.33 11.4 5.4 8.1 7.1 1.7 3.6 2 0 0 2 2 2 0 Zinc-finger double domain UAA PF08449.11 EFO61432.1 - 2.7e-12 46.5 22.0 1.2e-11 44.4 20.2 2.0 2 0 0 2 2 2 1 UAA transporter family EamA PF00892.20 EFO61432.1 - 0.00063 19.9 26.1 0.0011 19.2 13.3 2.6 2 0 0 2 2 2 2 EamA-like transporter family Ank_2 PF12796.7 EFO61433.1 - 8.1e-14 52.0 0.5 7.1e-09 36.1 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61433.1 - 2.2e-11 44.1 0.2 0.0002 21.9 0.0 3.8 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61433.1 - 3e-11 42.5 0.1 0.07 13.7 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EFO61433.1 - 2.2e-10 40.6 0.3 0.00068 19.9 0.0 4.0 3 2 2 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO61433.1 - 1.9e-06 28.1 0.0 0.44 11.1 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat MCPVI PF02993.14 EFO61433.1 - 0.5 10.2 3.6 19 5.0 3.6 2.3 1 1 0 1 1 1 0 Minor capsid protein VI Ank_2 PF12796.7 EFO61434.1 - 3.4e-86 283.9 37.6 7.2e-14 52.1 1.7 10.3 1 1 10 11 11 11 11 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61434.1 - 1.1e-45 153.4 18.1 1.3e-07 32.0 0.0 13.5 8 4 5 13 13 13 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO61434.1 - 7.3e-43 144.1 24.3 0.00029 21.1 0.0 16.4 5 4 12 17 17 17 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61434.1 - 2.9e-39 128.6 21.8 0.17 12.5 0.0 18.4 18 1 1 19 19 19 8 Ankyrin repeat Ank PF00023.30 EFO61434.1 - 2.2e-38 129.1 24.2 0.018 15.5 0.0 16.7 17 1 1 18 18 18 12 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO61434.1 - 6.4e-09 35.5 10.0 1.5e-08 34.3 10.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO61434.1 - 0.00012 21.8 9.4 0.00035 20.4 9.4 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFO61434.1 - 0.00083 19.6 11.0 0.0023 18.2 11.0 1.8 1 0 0 1 1 1 1 Ring finger domain SRP_TPR_like PF17004.5 EFO61434.1 - 0.095 12.7 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Putative TPR-like repeat zf-RING_5 PF14634.6 EFO61434.1 - 0.13 12.3 10.4 0.37 10.8 10.4 1.9 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFO61434.1 - 0.88 9.6 7.3 1.2 9.3 5.7 2.2 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_4 PF14570.6 EFO61434.1 - 2.4 8.0 8.4 7.3 6.5 8.4 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-B_box PF00643.24 EFO61434.1 - 6.1 7.1 7.4 6.2 7.1 5.8 1.9 1 1 0 1 1 1 0 B-box zinc finger Alg14 PF08660.11 EFO61435.1 - 8.1e-41 139.8 0.0 1e-40 139.5 0.0 1.1 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like ABC_tran PF00005.27 EFO61436.1 - 3.9e-44 150.5 0.0 8.4e-25 87.9 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFO61436.1 - 2e-40 139.2 47.6 2.5e-30 106.1 11.3 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EFO61436.1 - 1e-08 34.9 0.1 0.0057 16.1 0.0 4.1 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EFO61436.1 - 7.8e-06 25.9 0.1 0.19 11.8 0.0 3.3 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_21 PF13304.6 EFO61436.1 - 0.00061 19.7 0.0 0.81 9.4 0.0 3.6 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFO61436.1 - 0.00071 20.1 0.0 0.057 13.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFO61436.1 - 0.0013 19.1 0.2 0.52 10.6 0.0 2.9 2 1 0 2 2 2 1 AAA domain DUF87 PF01935.17 EFO61436.1 - 0.0066 16.6 0.2 0.046 13.8 0.0 2.2 2 0 0 2 2 2 1 Helicase HerA, central domain RsgA_GTPase PF03193.16 EFO61436.1 - 0.0078 16.1 0.0 1.9 8.3 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EFO61436.1 - 0.012 15.3 2.1 4.1 7.2 0.0 3.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EFO61436.1 - 0.019 15.3 0.1 1.2 9.5 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain GTP_EFTU PF00009.27 EFO61436.1 - 0.035 13.6 0.0 0.3 10.6 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain cobW PF02492.19 EFO61436.1 - 0.056 13.0 1.2 0.22 11.1 0.0 2.4 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 EFO61436.1 - 0.058 13.0 0.2 1.3 8.6 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 EFO61436.1 - 0.076 13.6 0.0 1.1 9.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EFO61436.1 - 0.083 13.1 0.0 1.9 8.8 0.0 2.7 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.6 EFO61436.1 - 0.12 12.5 0.3 0.66 10.1 0.0 2.3 3 0 0 3 3 2 0 AAA domain TsaE PF02367.17 EFO61436.1 - 0.15 12.0 0.0 2.3 8.2 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TrwB_AAD_bind PF10412.9 EFO61436.1 - 0.2 10.5 0.1 13 4.5 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Dynamin_N PF00350.23 EFO61436.1 - 0.26 11.3 0.7 11 6.1 0.0 2.4 2 0 0 2 2 2 0 Dynamin family VSP PF03302.13 EFO61437.1 - 1e-22 80.6 30.5 1.4e-22 80.1 30.5 1.1 1 0 0 1 1 1 1 Giardia variant-specific surface protein Profilin PF00235.19 EFO61437.1 - 0.046 14.0 0.4 0.095 13.0 0.4 1.5 1 0 0 1 1 1 0 Profilin Selenoprotein_S PF06936.11 EFO61437.1 - 0.17 11.7 0.5 0.28 11.0 0.5 1.3 1 0 0 1 1 1 0 Selenoprotein S (SelS) Peptidase_C1 PF00112.23 EFO61438.1 - 3.7e-27 95.9 6.0 1.1e-26 94.3 4.4 2.5 2 1 0 2 2 2 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFO61438.1 - 0.0033 16.3 0.1 0.0067 15.3 0.1 1.4 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C39_2 PF13529.6 EFO61438.1 - 0.039 14.5 0.8 0.12 12.9 0.0 2.2 2 1 1 3 3 3 0 Peptidase_C39 like family BrkDBD PF09607.10 EFO61438.1 - 0.047 13.5 0.3 0.4 10.5 0.2 2.3 2 0 0 2 2 2 0 Brinker DNA-binding domain tRNA-synt_1c PF00749.21 EFO61439.1 - 3.8e-98 328.3 0.0 5.6e-98 327.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EFO61439.1 - 1.5e-31 109.7 0.0 2.4e-31 108.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R1 PF04558.15 EFO61439.1 - 1.2e-15 57.9 0.1 4.5e-15 56.0 0.0 2.0 2 0 0 2 2 2 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 AMMECR1 PF01871.17 EFO61440.1 - 1.1e-38 132.5 0.0 1.3e-38 132.2 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 AMP-binding PF00501.28 EFO61441.1 - 1.5e-79 267.6 0.1 3.8e-78 263.0 0.1 2.0 1 1 0 1 1 1 1 AMP-binding enzyme DEAD PF00270.29 EFO61442.1 - 2.6e-21 76.2 0.1 8e-21 74.6 0.1 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Sec63 PF02889.16 EFO61442.1 - 3.8e-17 62.3 0.7 8.7e-17 61.1 0.7 1.7 1 0 0 1 1 1 1 Sec63 Brl domain ResIII PF04851.15 EFO61442.1 - 1.8e-11 44.3 0.0 4.6e-11 43.0 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFO61442.1 - 6.8e-10 39.3 0.0 1.4e-08 35.1 0.0 2.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain UvrD-helicase PF00580.21 EFO61442.1 - 0.049 13.1 0.2 11 5.5 0.0 2.5 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 EFO61442.1 - 0.081 13.3 0.1 12 6.2 0.0 3.0 2 0 0 2 2 2 0 AAA domain Inositol_P PF00459.25 EFO61443.1 - 9.1e-23 81.1 0.0 5e-11 42.6 0.0 3.0 3 0 0 3 3 3 3 Inositol monophosphatase family Ank_2 PF12796.7 EFO61444.1 - 3.6e-127 415.2 36.4 2.4e-14 53.7 0.1 14.7 2 2 12 15 15 15 15 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61444.1 - 2.9e-67 221.8 39.2 2.9e-05 24.2 0.0 23.0 8 5 16 24 24 24 19 Ankyrin repeats (many copies) Ank PF00023.30 EFO61444.1 - 4.3e-67 219.8 33.5 0.0042 17.5 0.1 23.9 21 3 2 23 23 23 18 Ankyrin repeat Ank_4 PF13637.6 EFO61444.1 - 8e-67 220.8 24.6 2.2e-05 24.9 0.0 19.4 12 6 8 21 21 21 16 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61444.1 - 1.9e-57 184.5 27.9 0.011 16.2 0.0 26.3 29 0 0 29 29 29 12 Ankyrin repeat Pkinase PF00069.25 EFO61444.1 - 2.9e-05 23.6 0.0 0.0073 15.7 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain DUF3447 PF11929.8 EFO61444.1 - 7e-05 22.7 0.9 0.23 11.4 0.1 4.4 3 1 1 4 4 4 2 Domain of unknown function (DUF3447) DUF5044 PF16447.5 EFO61444.1 - 0.037 13.9 0.3 0.11 12.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5044) Mt_ATP_synt PF15704.5 EFO61444.1 - 0.058 13.3 4.7 1.2 9.0 0.6 3.7 4 0 0 4 4 4 0 Mitochondrial ATP synthase subunit AhpC-TSA PF00578.21 EFO61445.1 - 1.9e-10 40.7 0.0 2.5e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFO61445.1 - 4.5e-09 36.2 0.0 5.8e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Redoxin Thioredoxin PF00085.20 EFO61445.1 - 9.6e-07 28.7 0.2 1.2e-06 28.5 0.2 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EFO61445.1 - 3.2e-06 27.4 0.0 4.3e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_3 PF13192.6 EFO61445.1 - 0.015 15.3 0.0 2.9 8.0 0.0 2.4 1 1 1 2 2 2 0 Thioredoxin domain Thioredoxin_9 PF14595.6 EFO61445.1 - 0.03 14.1 0.1 0.27 11.0 0.2 2.3 1 1 1 2 2 2 0 Thioredoxin Thioredoxin_2 PF13098.6 EFO61445.1 - 0.062 13.8 0.1 0.078 13.4 0.1 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain Pkinase PF00069.25 EFO61446.1 - 6e-21 75.0 0.0 2e-10 40.5 0.0 3.8 4 0 0 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61446.1 - 7.2e-08 32.0 0.0 1.3e-06 27.9 0.0 2.5 3 0 0 3 3 3 1 Protein tyrosine kinase APH PF01636.23 EFO61446.1 - 0.028 14.3 0.1 0.046 13.6 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family LSM PF01423.22 EFO61447.1 - 4.7e-12 45.4 0.0 6.1e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFO61447.1 - 0.00016 21.8 0.0 0.00021 21.4 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EFO61447.1 - 0.066 13.3 0.0 0.096 12.8 0.0 1.4 1 1 0 1 1 1 0 Scd6-like Sm domain Hfq PF17209.3 EFO61447.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Hfq protein UNC45-central PF11701.8 EFO61448.1 - 2.3 8.1 9.8 4.4 7.2 0.2 4.2 3 1 1 4 4 4 0 Myosin-binding striated muscle assembly central SMI1_KNR4 PF09346.10 EFO61449.1 - 0.0019 18.6 0.1 0.006 17.0 0.1 1.7 1 1 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) Methyltransf_8 PF05148.15 EFO61450.1 - 1.2e-52 179.0 0.0 2.2e-50 171.6 0.0 2.1 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EFO61450.1 - 5.2e-06 27.0 0.1 2.3e-05 25.0 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFO61450.1 - 1.3e-05 25.8 0.1 0.00095 19.8 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFO61450.1 - 0.00036 20.3 0.0 0.45 10.3 0.0 2.2 1 1 1 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 EFO61450.1 - 0.0019 17.6 0.0 0.0027 17.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EFO61450.1 - 0.0076 15.8 0.0 3 7.4 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase small domain Methyltransf_2 PF00891.18 EFO61450.1 - 0.013 14.8 0.0 0.026 13.8 0.0 1.5 2 0 0 2 2 2 0 O-methyltransferase domain Methyltransf_23 PF13489.6 EFO61450.1 - 0.1 12.5 0.0 0.44 10.4 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain PIH1_CS PF18201.1 EFO61451.1 - 3.5e-09 37.0 0.0 5.1e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 PIH1 CS-like domain ArsA_HSP20 PF17886.1 EFO61451.1 - 4.8e-07 29.2 0.0 7.6e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 EFO61451.1 - 0.0022 19.0 0.0 0.0034 18.4 0.0 1.3 1 0 0 1 1 1 1 CS domain HSP20 PF00011.21 EFO61451.1 - 0.014 15.5 0.0 0.064 13.4 0.0 2.1 1 1 0 1 1 1 0 Hsp20/alpha crystallin family AAA PF00004.29 EFO61452.1 - 5.7e-41 140.0 0.0 8.5e-29 100.6 0.0 3.0 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFO61452.1 - 3.6e-10 40.2 3.3 4.1e-05 23.9 0.2 4.5 3 2 0 3 3 3 2 AAA domain AAA_16 PF13191.6 EFO61452.1 - 2e-09 38.0 0.3 0.00044 20.7 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain T2SSE PF00437.20 EFO61452.1 - 3.1e-08 33.0 0.0 4.3e-05 22.7 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_14 PF13173.6 EFO61452.1 - 1.5e-05 25.1 0.0 0.059 13.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain cobW PF02492.19 EFO61452.1 - 3.5e-05 23.5 0.0 0.039 13.5 0.0 2.5 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 EFO61452.1 - 0.00011 21.8 0.0 0.1 12.1 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region Viral_helicase1 PF01443.18 EFO61452.1 - 0.00017 21.4 0.0 0.0094 15.7 0.0 2.6 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 EFO61452.1 - 0.00017 21.6 0.0 0.73 9.7 0.0 2.4 2 0 0 2 2 2 2 ATPase domain predominantly from Archaea TIP49 PF06068.13 EFO61452.1 - 0.00022 20.5 0.0 0.00064 19.0 0.0 1.7 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_33 PF13671.6 EFO61452.1 - 0.00024 21.3 0.0 0.15 12.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EFO61452.1 - 0.00063 19.7 0.2 0.28 11.1 0.1 3.4 2 1 0 2 2 2 1 NACHT domain Mg_chelatase PF01078.21 EFO61452.1 - 0.0012 18.2 0.0 0.053 12.9 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI FtsK_SpoIIIE PF01580.18 EFO61452.1 - 0.0031 16.9 0.1 2.5 7.4 0.0 3.0 3 0 0 3 3 3 1 FtsK/SpoIIIE family AAA_18 PF13238.6 EFO61452.1 - 0.0042 17.6 0.0 3.8 8.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFO61452.1 - 0.0055 16.4 0.1 1.3 8.8 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EFO61452.1 - 0.0058 17.1 0.0 4.3 7.9 0.0 2.8 3 0 0 3 3 2 1 ABC transporter DUF815 PF05673.13 EFO61452.1 - 0.0082 15.3 0.0 2.4 7.3 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_19 PF13245.6 EFO61452.1 - 0.011 16.1 0.0 1.5 9.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EFO61452.1 - 0.011 15.8 0.0 1.8 8.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PIF1 PF05970.14 EFO61452.1 - 0.015 14.4 0.0 0.13 11.4 0.0 2.0 2 0 0 2 2 2 0 PIF1-like helicase UvrD-helicase PF00580.21 EFO61452.1 - 0.017 14.6 0.0 0.068 12.7 0.0 2.0 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain RNA_helicase PF00910.22 EFO61452.1 - 0.019 15.3 0.0 3.1 8.2 0.0 2.9 2 0 0 2 2 2 0 RNA helicase RNA12 PF10443.9 EFO61452.1 - 0.023 13.5 0.0 0.18 10.5 0.0 2.0 2 0 0 2 2 2 0 RNA12 protein Sigma54_activat PF00158.26 EFO61452.1 - 0.027 14.2 0.0 1.6 8.4 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain NB-ARC PF00931.22 EFO61452.1 - 0.03 13.5 0.0 2.8 7.0 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain MobB PF03205.14 EFO61452.1 - 0.031 14.2 0.1 0.58 10.1 0.0 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.17 EFO61452.1 - 0.043 13.8 0.0 4.1 7.4 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TrwB_AAD_bind PF10412.9 EFO61452.1 - 0.061 12.2 0.0 2.1 7.2 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain KAP_NTPase PF07693.14 EFO61452.1 - 0.069 12.4 0.0 8.1 5.6 0.0 2.3 2 0 0 2 2 2 0 KAP family P-loop domain AAA_30 PF13604.6 EFO61452.1 - 0.074 12.8 0.0 3.3 7.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain WD40 PF00400.32 EFO61453.1 - 0.00017 22.3 8.3 0.0065 17.3 0.4 4.9 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO61453.1 - 0.0045 17.3 0.0 4.9 7.5 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_S7e PF01251.18 EFO61454.1 - 1e-57 194.9 0.1 1.2e-57 194.6 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e FR47 PF08445.10 EFO61454.1 - 0.056 13.4 0.0 0.27 11.2 0.0 1.9 2 0 0 2 2 2 0 FR47-like protein DUF4464 PF14713.6 EFO61455.1 - 2.8e-81 272.3 5.0 3.2e-81 272.2 5.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4464) RteC PF09357.10 EFO61455.1 - 0.05 13.3 1.8 0.15 11.7 0.3 2.0 2 0 0 2 2 2 0 RteC protein SIR2 PF02146.17 EFO61456.1 - 3.2e-06 27.2 0.0 0.0015 18.5 0.0 2.6 2 0 0 2 2 2 2 Sir2 family PolyA_pol PF01743.20 EFO61457.1 - 1.3e-28 100.0 0.0 2.7e-28 98.9 0.0 1.6 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EFO61457.1 - 0.00036 20.2 0.3 0.00085 19.0 0.3 1.6 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A RNA_pol_Rpc34 PF05158.12 EFO61458.1 - 3.5e-11 43.1 0.0 4.4e-10 39.5 0.0 1.9 1 1 1 2 2 2 1 RNA polymerase Rpc34 subunit DUF3793 PF12672.7 EFO61458.1 - 0.067 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3793) LytR_C PF13399.6 EFO61458.1 - 0.068 14.2 0.7 0.16 13.0 0.7 1.7 1 1 0 1 1 1 0 LytR cell envelope-related transcriptional attenuator Penicillinase_R PF03965.16 EFO61458.1 - 0.12 12.7 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 Penicillinase repressor Mnd1 PF03962.15 EFO61458.1 - 0.13 12.6 0.1 23 5.4 0.0 2.5 2 0 0 2 2 2 0 Mnd1 HTH domain VSP PF03302.13 EFO61459.1 - 1.3e-78 264.6 188.5 1.4e-35 122.9 29.2 6.0 1 1 5 6 6 6 5 Giardia variant-specific surface protein SKG6 PF08693.10 EFO61459.1 - 0.35 10.3 4.4 0.87 9.0 4.4 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Podoplanin PF05808.11 EFO61459.1 - 0.47 10.5 0.0 0.47 10.5 0.0 3.8 3 1 1 4 4 4 0 Podoplanin Ank_2 PF12796.7 EFO61460.1 - 9.2e-112 365.8 36.2 2.9e-15 56.6 0.2 10.6 1 1 12 14 14 14 14 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61460.1 - 2.1e-55 184.4 15.7 5.7e-07 30.0 0.1 14.5 8 5 6 14 14 14 12 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61460.1 - 6.8e-52 167.4 7.7 0.0019 18.5 0.0 19.4 19 1 1 20 20 19 10 Ankyrin repeat Ank_5 PF13857.6 EFO61460.1 - 2.7e-51 170.9 22.4 9.1e-06 25.9 0.0 15.1 6 3 8 15 15 15 12 Ankyrin repeats (many copies) Ank PF00023.30 EFO61460.1 - 1.6e-47 157.9 4.8 0.00021 21.6 0.0 17.6 17 2 1 18 18 18 11 Ankyrin repeat Pkinase PF00069.25 EFO61460.1 - 3.6e-20 72.4 0.0 1.3e-19 70.6 0.0 2.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61460.1 - 5e-14 52.2 0.0 1.4e-13 50.7 0.0 1.8 1 0 0 1 1 1 1 Protein tyrosine kinase CdAMP_rec PF06153.11 EFO61460.1 - 0.0084 16.3 0.2 1 9.6 0.1 3.5 2 1 1 3 3 3 1 Cyclic-di-AMP receptor Phage_T7_Capsid PF05396.11 EFO61460.1 - 0.062 13.7 0.2 7.4 7.0 0.0 3.3 3 0 0 3 3 3 0 Phage T7 capsid assembly protein TIR-like PF10137.9 EFO61460.1 - 0.063 13.3 0.0 0.23 11.4 0.0 2.1 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain APH PF01636.23 EFO61460.1 - 0.13 12.1 0.7 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family VSP PF03302.13 EFO61461.1 - 1.3e-147 491.8 156.4 1.8e-143 478.1 109.0 4.0 1 1 3 4 4 4 2 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO61461.1 - 0.049 13.7 0.1 0.049 13.7 0.1 3.0 3 0 0 3 3 3 0 Podoplanin Ribosomal_L18A PF01775.17 EFO61463.1 - 8.4e-48 161.5 0.7 1.1e-47 161.1 0.7 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Lipase_3 PF01764.25 EFO61465.1 - 4.6e-16 59.0 0.0 8.2e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Chlorophyllase2 PF12740.7 EFO61465.1 - 0.0071 15.3 0.4 0.027 13.4 0.2 1.8 2 0 0 2 2 2 1 Chlorophyllase enzyme PGAP1 PF07819.13 EFO61465.1 - 0.011 15.5 0.0 0.016 14.9 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_6 PF12697.7 EFO61465.1 - 0.017 15.8 0.0 0.031 14.9 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Thioesterase PF00975.20 EFO61465.1 - 0.047 13.8 0.0 0.37 10.9 0.0 2.4 3 0 0 3 3 3 0 Thioesterase domain Esterase PF00756.20 EFO61465.1 - 0.12 12.0 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Putative esterase NAD_synthase PF02540.17 EFO61466.1 - 3.4e-36 124.6 0.0 4.1e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 NAD synthase Asn_synthase PF00733.21 EFO61466.1 - 0.13 11.8 0.1 0.23 11.1 0.1 1.3 1 0 0 1 1 1 0 Asparagine synthase DUF16 PF01519.16 EFO61467.1 - 0.0012 19.3 0.8 0.0012 19.3 0.8 3.7 2 1 2 4 4 4 1 Protein of unknown function DUF16 Shugoshin_N PF07558.11 EFO61467.1 - 0.004 17.0 5.1 0.019 14.8 5.1 2.2 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region TSC22 PF01166.18 EFO61467.1 - 0.034 14.4 7.1 0.23 11.8 1.6 3.8 3 0 0 3 3 3 0 TSC-22/dip/bun family NPV_P10 PF05531.12 EFO61467.1 - 0.21 12.1 24.1 2.4 8.7 0.6 5.5 2 2 3 5 5 5 0 Nucleopolyhedrovirus P10 protein DUF2939 PF11159.8 EFO61467.1 - 0.46 10.9 3.9 1.9 9.0 0.2 3.5 2 1 2 4 4 4 0 Protein of unknown function (DUF2939) Herpes_BLRF2 PF05812.12 EFO61467.1 - 0.63 10.2 10.7 1.1 9.4 0.5 3.5 2 1 1 3 3 3 0 Herpesvirus BLRF2 protein DUF4407 PF14362.6 EFO61467.1 - 1.1 8.5 12.0 0.2 11.0 3.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) DUF4164 PF13747.6 EFO61467.1 - 1.2 9.4 13.1 0.84 10.0 0.4 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4164) OmpH PF03938.14 EFO61467.1 - 3.5 7.9 18.2 0.36 11.2 0.3 3.9 2 2 2 4 4 4 0 Outer membrane protein (OmpH-like) CENP-F_leu_zip PF10473.9 EFO61467.1 - 9.6 6.2 22.5 0.88 9.6 0.5 4.6 4 1 0 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF5366 PF17328.2 EFO61468.1 - 9.5 6.3 17.2 3.8 7.6 8.8 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5366) VSP PF03302.13 EFO61469.1 - 3.1e-76 256.8 165.3 4.5e-68 229.9 87.9 4.9 1 1 2 5 5 5 4 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO61469.1 - 0.00036 20.7 15.5 0.00036 20.7 15.5 12.5 3 2 9 13 13 13 3 Furin-like repeat, cysteine-rich Peptidase_C27 PF05407.12 EFO61469.1 - 0.003 17.7 0.7 0.0074 16.4 0.7 1.6 1 0 0 1 1 1 1 Rubella virus endopeptidase DUF384 PF04064.13 EFO61470.1 - 7.3e-05 22.6 0.1 0.00015 21.5 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF384) VCBS PF13517.6 EFO61472.1 - 0.021 15.4 4.3 23 5.7 0.0 5.0 5 1 0 5 5 5 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Annexin PF00191.20 EFO61473.1 - 1.4e-17 63.5 0.3 4.7e-08 33.0 0.0 3.9 4 0 0 4 4 4 3 Annexin LRR_4 PF12799.7 EFO61475.1 - 1.4e-07 31.7 9.5 0.033 14.6 0.5 4.0 1 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO61475.1 - 5.5e-05 22.8 8.5 0.16 11.7 0.4 3.6 1 1 2 3 3 3 3 Leucine rich repeat LRR_9 PF14580.6 EFO61475.1 - 0.0039 16.7 2.3 0.15 11.5 0.9 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 EFO61475.1 - 0.069 13.7 5.6 10 7.1 0.4 4.7 3 2 1 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.6 EFO61475.1 - 0.75 10.0 3.0 57 4.1 0.1 3.8 3 1 1 4 4 4 0 Leucine Rich repeat TRAPP PF04051.16 EFO61477.1 - 4.7e-05 23.1 0.0 6.1e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Arf PF00025.21 EFO61478.1 - 7.1e-77 256.8 0.0 8.1e-77 256.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFO61478.1 - 8.8e-14 51.3 0.0 1.1e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EFO61478.1 - 1.1e-13 51.4 0.0 1.6e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFO61478.1 - 1.4e-13 50.7 0.0 8.7e-10 38.3 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EFO61478.1 - 1.1e-10 41.3 0.0 1.3e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFO61478.1 - 1.3e-10 41.0 0.0 1.7e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFO61478.1 - 1.2e-05 25.4 0.0 1.8e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EFO61478.1 - 0.0011 18.3 0.1 0.0016 17.8 0.1 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase cobW PF02492.19 EFO61478.1 - 0.032 13.8 0.2 0.47 10.0 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 EFO61478.1 - 0.034 14.7 0.0 0.074 13.6 0.0 1.5 1 1 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 EFO61478.1 - 0.056 13.6 0.1 0.081 13.1 0.1 1.5 1 1 0 1 1 1 0 AAA domain Asparaginase PF00710.20 EFO61479.1 - 2.2e-59 200.3 0.0 3e-59 199.8 0.0 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EFO61479.1 - 4.8e-24 84.8 0.0 8.2e-24 84.0 0.0 1.4 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain HAD_2 PF13419.6 EFO61480.1 - 3.6e-28 98.8 0.0 7.5e-28 97.8 0.0 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFO61480.1 - 1.8e-11 43.9 0.0 3.5e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EFO61480.1 - 6.5e-11 42.9 0.0 1.6e-10 41.6 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFO61480.1 - 0.05 14.0 0.1 0.23 11.8 0.1 2.1 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Metallophos PF00149.28 EFO61481.1 - 6.5e-25 88.8 0.0 9.2e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFO61481.1 - 0.011 16.0 0.0 0.033 14.4 0.0 1.8 2 1 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain LMBR1 PF04791.16 EFO61483.1 - 8.6e-38 130.5 20.7 6.5e-37 127.6 20.7 1.9 1 1 0 1 1 1 1 LMBR1-like membrane protein DUF1126 PF06565.12 EFO61484.1 - 2.1e-80 265.3 1.6 2.3e-34 117.4 0.1 3.2 3 0 0 3 3 3 3 DUF1126 PH-like domain Herpes_IE68 PF02479.16 EFO61484.1 - 0.029 14.0 0.2 0.2 11.3 0.0 2.2 2 0 0 2 2 2 0 Herpesvirus immediate early protein DUF4880 PF16220.5 EFO61485.1 - 0.56 10.1 5.8 0.23 11.4 1.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4880) TPX2 PF06886.11 EFO61485.1 - 1.6 9.0 18.0 0.29 11.4 13.7 2.1 2 1 0 2 2 2 0 Targeting protein for Xklp2 (TPX2) KptA_kDCL PF18176.1 EFO61486.1 - 0.13 12.1 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 KptA in kinetoplastid DICER domain RVT_1 PF00078.27 EFO61487.1 - 4.8e-09 36.1 0.0 6.7e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_9 PF16293.5 EFO61487.1 - 0.015 15.1 0.1 0.027 14.3 0.1 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) zf-met PF12874.7 EFO61487.1 - 0.17 12.3 0.0 0.31 11.5 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EFO61487.1 - 0.2 12.6 0.0 0.44 11.5 0.0 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger GAGA PF09237.11 EFO61488.1 - 0.084 12.7 0.4 0.17 11.7 0.4 1.4 1 0 0 1 1 1 0 GAGA factor zf-C2H2_11 PF16622.5 EFO61488.1 - 3.8 7.4 8.8 0.15 11.8 1.8 2.1 2 0 0 2 2 2 0 zinc-finger C2H2-type NOT2_3_5 PF04153.18 EFO61489.1 - 3.5e-09 36.8 0.0 5.7e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family PAP2_3 PF14378.6 EFO61489.1 - 0.097 12.3 0.1 0.15 11.7 0.1 1.2 1 0 0 1 1 1 0 PAP2 superfamily zf-RING_UBOX PF13445.6 EFO61490.1 - 0.00031 20.7 5.5 0.00031 20.7 5.5 2.2 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFO61490.1 - 0.001 18.9 4.7 0.001 18.9 4.7 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFO61490.1 - 0.0023 17.7 4.6 0.0023 17.7 4.6 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFO61490.1 - 0.0074 16.4 3.4 0.0074 16.4 3.4 3.3 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING cwf18 PF08315.12 EFO61490.1 - 0.052 14.2 0.1 0.086 13.5 0.1 1.3 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor RE_Bsp6I PF09504.10 EFO61490.1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Bsp6I restriction endonuclease zf-Nse PF11789.8 EFO61490.1 - 0.18 11.7 3.7 0.1 12.4 0.5 2.2 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_3 PF13920.6 EFO61491.1 - 2.5e-12 46.5 14.7 3.8e-12 45.9 14.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO61491.1 - 8.6e-06 25.5 13.3 1.6e-05 24.7 13.3 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFO61491.1 - 0.00075 19.8 16.3 0.0014 18.9 16.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C4H2 PF10146.9 EFO61491.1 - 0.064 13.6 0.6 0.07 13.4 0.6 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein zf-RING_5 PF14634.6 EFO61491.1 - 0.71 9.9 14.6 1.4 9.0 14.6 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFO61491.1 - 2 8.3 16.3 3.5 7.5 16.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Vps39_2 PF10367.9 EFO61492.1 - 0.00035 21.0 0.0 0.0012 19.3 0.0 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 DUF3099 PF11298.8 EFO61493.1 - 0.056 13.6 1.5 0.1 12.8 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3099) Queuosine_synth PF02547.15 EFO61493.1 - 0.19 10.8 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein DIX PF00778.17 EFO61494.1 - 0.062 13.1 0.3 0.12 12.2 0.3 1.4 1 0 0 1 1 1 0 DIX domain LSM PF01423.22 EFO61495.1 - 8.4e-18 63.8 0.0 1e-17 63.6 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFO61495.1 - 0.001 19.2 0.0 0.0014 18.7 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain Tudor_2 PF18104.1 EFO61495.1 - 0.12 12.0 1.0 0.15 11.7 0.1 1.7 2 0 0 2 2 2 0 Jumonji domain-containing protein 2A Tudor domain CoaE PF01121.20 EFO61496.1 - 7e-34 117.0 0.0 1.7e-32 112.6 0.0 2.1 1 1 0 1 1 1 1 Dephospho-CoA kinase AAA_33 PF13671.6 EFO61496.1 - 3e-05 24.2 0.0 7.6e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFO61496.1 - 0.0025 18.4 0.3 0.014 15.9 0.1 2.2 3 1 0 3 3 3 1 AAA domain AAA_28 PF13521.6 EFO61496.1 - 0.013 15.7 0.0 0.033 14.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain dNK PF01712.19 EFO61496.1 - 0.018 14.9 0.2 0.073 12.9 0.0 2.1 3 0 0 3 3 3 0 Deoxynucleoside kinase RBM39linker PF15519.6 EFO61497.1 - 0.09 13.9 0.2 5.8 8.1 0.0 2.3 2 0 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein LRRNT_2 PF08263.12 EFO61498.1 - 9.3e-06 25.8 0.8 2e-05 24.8 0.8 1.6 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_8 PF13855.6 EFO61498.1 - 1.1e-05 25.1 5.0 1.1e-05 25.1 5.0 2.7 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 EFO61498.1 - 0.00037 20.8 16.6 0.009 16.4 2.4 4.0 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFO61498.1 - 0.074 13.6 17.1 6 7.8 0.0 5.4 4 2 1 5 5 5 0 Leucine Rich Repeat SHE3 PF17078.5 EFO61501.1 - 0.00078 19.2 1.1 0.00078 19.2 1.1 3.9 2 1 1 3 3 3 1 SWI5-dependent HO expression protein 3 AKNA PF12443.8 EFO61501.1 - 0.0026 18.4 8.4 0.0073 16.9 0.3 4.3 3 1 1 4 4 4 1 AT-hook-containing transcription factor RPW8 PF05659.11 EFO61501.1 - 0.01 15.5 3.1 0.01 15.5 3.1 4.7 3 1 1 6 6 6 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 TMF_TATA_bd PF12325.8 EFO61501.1 - 0.023 14.9 70.1 0.86 9.8 11.3 6.5 3 2 3 6 6 6 0 TATA element modulatory factor 1 TATA binding TACC_C PF05010.14 EFO61501.1 - 0.048 13.4 48.6 0.037 13.8 16.3 4.4 2 1 1 4 4 4 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Spc7 PF08317.11 EFO61501.1 - 0.31 9.9 64.8 0.31 9.9 8.8 5.2 2 1 3 5 5 5 0 Spc7 kinetochore protein DivIC PF04977.15 EFO61501.1 - 2.2 8.1 0.0 2.1 8.2 0.8 9.0 4 2 4 9 9 9 0 Septum formation initiator DUF1664 PF07889.12 EFO61501.1 - 2.3 8.3 27.0 0.69 10.0 0.2 5.5 2 1 4 6 6 6 0 Protein of unknown function (DUF1664) HMMR_N PF15905.5 EFO61501.1 - 6.6 6.1 63.2 0.48 9.9 11.8 4.1 2 1 2 4 4 4 0 Hyaluronan mediated motility receptor N-terminal GAS PF13851.6 EFO61501.1 - 9.9 5.5 64.8 0.068 12.5 8.4 5.5 2 2 4 6 6 6 0 Growth-arrest specific micro-tubule binding Ank_2 PF12796.7 EFO61502.1 - 1.3e-127 416.7 46.3 7.4e-16 58.5 1.0 13.6 1 1 12 14 14 14 14 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61502.1 - 7.9e-71 233.6 40.4 5.5e-08 33.2 0.1 18.7 14 6 5 20 20 20 15 Ankyrin repeats (many copies) Ank PF00023.30 EFO61502.1 - 1e-66 218.6 49.9 0.00056 20.2 0.1 24.8 22 5 4 26 26 26 13 Ankyrin repeat Ank_3 PF13606.6 EFO61502.1 - 1.1e-64 206.7 37.7 0.0031 17.9 0.1 26.7 27 0 0 27 27 27 13 Ankyrin repeat Ank_5 PF13857.6 EFO61502.1 - 2.5e-58 193.4 40.4 0.00012 22.3 0.0 19.8 7 5 15 22 22 22 16 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO61502.1 - 3.3e-50 170.9 0.0 6.1e-50 170.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61502.1 - 4.7e-29 101.5 0.0 1.2e-28 100.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EFO61502.1 - 0.0019 18.2 0.0 0.0036 17.2 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFO61502.1 - 0.056 12.2 0.0 0.093 11.5 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Metallophos PF00149.28 EFO61503.1 - 2.7e-37 129.3 0.1 3.6e-37 128.9 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFO61503.1 - 9.6e-05 22.8 0.8 0.00039 20.8 0.8 2.0 1 1 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 EFO61503.1 - 0.12 12.6 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain TMA7 PF09072.10 EFO61504.1 - 0.0001 23.0 17.9 0.00011 22.9 17.9 1.1 1 0 0 1 1 1 1 Translation machinery associated TMA7 Rhodanese PF00581.20 EFO61505.1 - 4.3e-05 24.0 0.0 0.00011 22.7 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain LIAS_N PF16881.5 EFO61505.1 - 0.027 14.9 0.2 2.5 8.6 0.1 2.8 2 1 0 2 2 2 0 N-terminal domain of lipoyl synthase of Radical_SAM family Methyltransf_25 PF13649.6 EFO61506.1 - 7.1e-06 26.7 0.0 1.2e-05 25.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFO61506.1 - 1e-05 25.3 0.0 1.2e-05 25.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFO61506.1 - 1.9e-05 25.2 0.0 2.9e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFO61506.1 - 0.00099 19.8 0.0 0.0015 19.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DUF2258 PF10015.9 EFO61506.1 - 0.18 12.0 0.0 0.3 11.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2258) Macoilin PF09726.9 EFO61507.1 - 0.00087 18.0 14.8 0.00087 18.0 14.8 2.1 1 1 1 2 2 2 1 Macoilin family DUF812 PF05667.11 EFO61507.1 - 0.0097 14.8 27.4 0.013 14.4 27.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) TPR_MLP1_2 PF07926.12 EFO61507.1 - 0.013 15.6 11.2 0.013 15.6 11.2 3.5 4 0 0 4 4 4 0 TPR/MLP1/MLP2-like protein L27_1 PF09058.10 EFO61507.1 - 0.015 15.2 0.4 0.097 12.7 0.4 2.4 1 0 0 1 1 1 0 L27_1 DUF1722 PF08349.11 EFO61507.1 - 0.026 14.8 0.4 0.097 13.0 0.4 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) DUF244 PF03112.14 EFO61507.1 - 0.81 9.5 4.8 0.12 12.2 0.5 1.9 2 0 0 2 2 2 0 Uncharacterized protein family (ORF7) DUF DUF3510 PF12022.8 EFO61507.1 - 0.88 10.0 13.3 1.1 9.6 0.3 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF3510) Golgin_A5 PF09787.9 EFO61507.1 - 2.8 7.3 27.8 2.3 7.6 21.2 2.4 2 0 0 2 2 2 0 Golgin subfamily A member 5 SlyX PF04102.12 EFO61507.1 - 6.9 7.4 31.1 30 5.3 0.0 6.1 4 2 2 6 6 6 0 SlyX CAP_N PF01213.19 EFO61507.1 - 7.2 6.0 17.0 0.038 13.5 7.6 1.9 2 1 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal DUF4407 PF14362.6 EFO61507.1 - 9 5.6 34.7 7.8 5.7 10.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Presenilin PF01080.17 EFO61509.1 - 0.032 13.0 0.4 0.034 12.9 0.4 1.0 1 0 0 1 1 1 0 Presenilin Phospholamban PF04272.14 EFO61509.1 - 0.042 13.3 1.3 0.052 13.0 1.3 1.2 1 0 0 1 1 1 0 Phospholamban DHHC PF01529.20 EFO61511.1 - 3.9e-25 88.5 11.0 3.9e-25 88.5 11.0 2.4 2 0 0 2 2 2 2 DHHC palmitoyltransferase CsiV PF10972.8 EFO61511.1 - 0.026 14.3 0.0 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 Peptidoglycan-binding protein, CsiV DUF2781 PF10914.8 EFO61511.1 - 3 8.2 6.8 0.62 10.5 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2781) DUF2254 PF10011.9 EFO61511.1 - 3.7 6.3 4.5 7.2 5.3 4.5 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) ABC_tran PF00005.27 EFO61512.1 - 6.5e-40 136.8 0.0 1.1e-21 77.7 0.0 3.7 4 2 0 4 4 3 2 ABC transporter ABC_tran_Xtn PF12848.7 EFO61512.1 - 9.7e-23 80.0 0.9 9.7e-23 80.0 0.9 2.6 3 0 0 3 3 2 1 ABC transporter AAA_21 PF13304.6 EFO61512.1 - 6.1e-19 68.9 7.1 0.0011 18.9 0.0 4.4 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFO61512.1 - 1.3e-15 57.4 0.0 5.8e-05 22.6 0.0 4.0 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EFO61512.1 - 3.3e-08 33.6 3.6 0.0015 18.3 0.1 3.6 3 2 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 EFO61512.1 - 2.6e-07 30.3 0.1 0.028 14.2 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EFO61512.1 - 5e-06 26.8 0.4 0.13 12.5 0.0 4.4 3 1 0 3 3 2 1 AAA domain AAA_23 PF13476.6 EFO61512.1 - 1.2e-05 25.9 14.9 0.0092 16.5 0.6 3.6 3 1 0 3 3 3 2 AAA domain AAA_18 PF13238.6 EFO61512.1 - 0.00012 22.6 0.6 0.043 14.4 0.0 3.4 4 0 0 4 4 3 1 AAA domain MMR_HSR1 PF01926.23 EFO61512.1 - 0.0002 21.4 0.2 0.38 10.9 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EFO61512.1 - 0.00046 20.6 0.4 1 9.7 0.0 3.0 3 1 0 3 3 2 1 AAA ATPase domain AAA_33 PF13671.6 EFO61512.1 - 0.00062 20.0 0.1 0.23 11.6 0.0 3.0 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 EFO61512.1 - 0.00086 19.2 0.6 1.8 8.4 0.0 2.9 3 0 0 3 3 3 2 RsgA GTPase AAA_28 PF13521.6 EFO61512.1 - 0.001 19.3 3.4 0.3 11.3 0.0 3.2 4 0 0 4 4 3 2 AAA domain G-alpha PF00503.20 EFO61512.1 - 0.002 17.4 0.1 0.14 11.3 0.0 2.7 2 1 0 3 3 3 1 G-protein alpha subunit AAA_30 PF13604.6 EFO61512.1 - 0.0025 17.5 0.0 0.96 9.1 0.0 2.9 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 EFO61512.1 - 0.0047 16.9 0.6 2.1 8.2 0.0 3.1 3 1 0 3 3 2 1 NACHT domain Egg_lysin PF01303.17 EFO61512.1 - 0.0059 16.8 0.1 0.013 15.7 0.1 1.6 1 0 0 1 1 1 1 Egg lysin (Sperm-lysin) AAA_24 PF13479.6 EFO61512.1 - 0.013 15.2 0.0 3.1 7.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 EFO61512.1 - 0.013 15.1 0.0 3.8 7.1 0.0 2.8 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EFO61512.1 - 0.015 14.7 0.2 0.32 10.3 0.0 2.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA PF00004.29 EFO61512.1 - 0.02 15.3 0.0 5.6 7.4 0.0 3.6 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 EFO61512.1 - 0.022 13.9 0.1 0.62 9.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ATP-synt_ab PF00006.25 EFO61512.1 - 0.044 13.4 0.0 9.1 5.9 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_13 PF13166.6 EFO61512.1 - 0.052 12.2 5.5 2.9 6.4 0.0 3.5 4 0 0 4 4 4 0 AAA domain Dynamin_N PF00350.23 EFO61512.1 - 0.053 13.6 3.3 2.4 8.2 0.1 3.5 3 1 0 3 3 3 0 Dynamin family DUF87 PF01935.17 EFO61512.1 - 0.054 13.6 6.5 4.6 7.3 0.0 4.4 4 1 0 4 4 4 0 Helicase HerA, central domain RNA_helicase PF00910.22 EFO61512.1 - 0.073 13.5 0.0 8.4 6.8 0.0 2.6 2 0 0 2 2 2 0 RNA helicase 5_3_exonuc_N PF02739.16 EFO61512.1 - 0.077 12.9 0.1 11 5.9 0.0 3.1 3 0 0 3 3 3 0 5'-3' exonuclease, N-terminal resolvase-like domain NB-ARC PF00931.22 EFO61512.1 - 0.079 12.1 0.0 6.1 5.9 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_7 PF12775.7 EFO61512.1 - 0.1 12.1 0.0 9.4 5.7 0.0 2.6 3 0 0 3 3 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 EFO61512.1 - 0.11 12.0 0.0 25 4.4 0.0 2.9 3 0 0 3 3 3 0 AAA domain Roc PF08477.13 EFO61512.1 - 0.13 12.5 0.0 12 6.2 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase HEAT PF02985.22 EFO61513.1 - 0.086 13.1 0.6 0.34 11.3 0.0 2.3 3 0 0 3 3 3 0 HEAT repeat AAA-ATPase_like PF09820.9 EFO61514.1 - 1.4e-10 41.1 0.0 1.9e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Predicted AAA-ATPase S_2TMBeta PF18153.1 EFO61514.1 - 0.01 15.7 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 SMODS-associating 2TM, beta-strand rich effector domain WD40 PF00400.32 EFO61515.1 - 2.5e-07 31.3 3.2 0.03 15.2 0.0 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat UTP15_C PF09384.10 EFO61515.1 - 0.00048 19.8 0.1 0.00073 19.2 0.1 1.2 1 0 0 1 1 1 1 UTP15 C terminal Ribosomal_L22 PF00237.19 EFO61516.1 - 1.5e-26 92.6 0.1 1.9e-26 92.3 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e KH_8 PF17903.1 EFO61517.1 - 0.0026 17.8 0.0 0.0063 16.6 0.0 1.6 2 0 0 2 2 2 1 Krr1 KH1 domain KH_1 PF00013.29 EFO61517.1 - 0.013 15.3 0.4 0.023 14.5 0.4 1.4 1 0 0 1 1 1 0 KH domain START PF01852.19 EFO61518.1 - 5.3e-05 22.7 0.0 8.2e-05 22.1 0.0 1.4 1 1 0 1 1 1 1 START domain VSP PF03302.13 EFO61519.1 - 9e-15 54.4 187.6 1.8e-05 23.8 26.3 8.6 1 1 6 8 8 8 8 Giardia variant-specific surface protein cEGF PF12662.7 EFO61519.1 - 0.026 14.5 2.4 0.026 14.5 2.4 11.5 9 3 0 9 9 9 0 Complement Clr-like EGF-like DUF4690 PF15756.5 EFO61519.1 - 0.51 11.0 1.5 1.2 9.8 1.5 1.6 1 0 0 1 1 1 0 Small Novel Rich in Cartilage OCRE PF17780.1 EFO61519.1 - 9.7 6.3 9.8 11 6.1 0.1 4.2 4 1 0 4 4 4 0 OCRE domain Ank_2 PF12796.7 EFO61520.1 - 3.2e-41 139.8 16.7 3.9e-11 43.4 0.1 6.4 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61520.1 - 2.2e-17 62.9 16.8 0.0013 19.0 0.0 8.5 6 2 3 9 9 9 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61520.1 - 1.2e-16 60.8 9.8 2.4e-06 28.0 0.1 7.4 4 2 4 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61520.1 - 8.7e-14 50.3 14.8 0.58 10.9 0.0 10.4 10 1 1 11 11 11 4 Ankyrin repeat Ank PF00023.30 EFO61520.1 - 8e-13 48.2 10.8 0.85 10.2 0.0 9.1 7 2 1 8 8 8 4 Ankyrin repeat CAGE1 PF15066.6 EFO61520.1 - 0.00052 18.8 0.2 0.0072 15.1 0.0 2.1 2 0 0 2 2 2 1 Cancer-associated gene protein 1 family Spc42p PF11544.8 EFO61520.1 - 0.022 14.8 1.3 4.7 7.3 0.0 2.8 3 0 0 3 3 3 0 Spindle pole body component Spc42p TMF_DNA_bd PF12329.8 EFO61520.1 - 0.21 11.6 4.0 8.1 6.5 0.1 3.2 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF4042 PF13251.6 EFO61521.1 - 0.00014 21.6 0.2 0.00041 20.1 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4042) Tugs PF17840.1 EFO61521.1 - 0.27 11.4 1.3 8.9 6.6 0.0 3.2 2 0 0 2 2 2 0 Tethering Ubl4a to BAGS domain Ribosomal_S2 PF00318.20 EFO61522.1 - 5e-22 78.2 0.4 2.1e-12 46.7 0.3 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 PG_binding_1 PF01471.18 EFO61526.1 - 0.018 15.3 0.7 0.05 13.8 0.7 1.8 1 0 0 1 1 1 0 Putative peptidoglycan binding domain Lbh PF15317.6 EFO61527.1 - 0.063 14.1 2.1 0.25 12.2 2.1 2.0 1 0 0 1 1 1 0 Cardiac transcription factor regulator, Developmental protein Rad60-SLD PF11976.8 EFO61528.1 - 8.1e-15 54.4 0.1 1.1e-14 54.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EFO61528.1 - 1.7e-06 27.7 0.0 2.1e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family B3 PF02362.21 EFO61528.1 - 0.053 13.4 0.0 0.068 13.0 0.0 1.2 1 0 0 1 1 1 0 B3 DNA binding domain DUF916 PF06030.12 EFO61528.1 - 0.072 13.2 0.1 0.096 12.8 0.1 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF916) MecA_N PF05223.11 EFO61528.1 - 0.1 12.9 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 NTF2-like N-terminal transpeptidase domain VSP PF03302.13 EFO61529.1 - 8.3e-69 232.3 139.1 2.4e-34 118.9 26.2 5.0 1 1 4 5 5 5 3 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO61529.1 - 0.00026 21.1 0.4 0.069 13.3 0.0 2.9 2 1 1 3 3 3 2 Podoplanin TGT PF01702.18 EFO61530.1 - 0.088 11.9 0.2 0.36 9.9 0.2 1.7 2 0 0 2 2 2 0 Queuine tRNA-ribosyltransferase PMT2_N PF17987.1 EFO61530.1 - 0.26 11.5 3.6 0.15 12.3 0.4 2.1 2 0 0 2 2 2 0 Phosphoethanolamine N-methyltransferase 2 N-terminal PMSR PF01625.21 EFO61532.1 - 5.1e-49 166.4 4.6 8.3e-47 159.2 4.6 2.0 1 1 0 1 1 1 1 Peptide methionine sulfoxide reductase SMC_N PF02463.19 EFO61533.1 - 0.062 12.7 0.0 0.14 11.6 0.0 1.5 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain ASXH PF13919.6 EFO61533.1 - 0.069 13.2 0.0 0.23 11.5 0.0 1.9 1 0 0 1 1 1 0 Asx homology domain TAFII55_N PF04658.13 EFO61534.1 - 2.2e-06 27.5 0.0 3.2e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 TAFII55 protein conserved region DUF775 PF05603.12 EFO61535.1 - 3.9e-17 62.4 0.0 3.1e-16 59.5 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF775) Erf4 PF10256.9 EFO61536.1 - 2.1 8.5 6.4 8.4 6.5 0.4 3.9 3 0 0 3 3 3 0 Golgin subfamily A member 7/ERF4 family Cep57_MT_bd PF06657.13 EFO61537.1 - 0.0027 18.1 4.4 0.0046 17.4 4.4 1.4 1 0 0 1 1 1 1 Centrosome microtubule-binding domain of Cep57 Golgin_A5 PF09787.9 EFO61537.1 - 0.0028 17.2 1.0 0.0036 16.8 1.0 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 5 Bac_GDH PF05088.12 EFO61537.1 - 0.0031 15.1 0.1 0.0037 14.9 0.1 1.0 1 0 0 1 1 1 1 Bacterial NAD-glutamate dehydrogenase DUF2229 PF09989.9 EFO61537.1 - 0.0033 17.1 0.0 0.0044 16.7 0.0 1.1 1 0 0 1 1 1 1 CoA enzyme activase uncharacterised domain (DUF2229) ApoLp-III PF07464.11 EFO61537.1 - 0.0037 17.4 1.4 0.0057 16.8 1.4 1.2 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) Rootletin PF15035.6 EFO61537.1 - 0.0057 16.7 1.3 0.0083 16.2 1.3 1.2 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion DUF812 PF05667.11 EFO61537.1 - 0.006 15.5 0.8 0.0063 15.5 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF4795 PF16043.5 EFO61537.1 - 0.0069 16.0 2.2 0.01 15.5 2.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) CENP-F_leu_zip PF10473.9 EFO61537.1 - 0.0096 16.0 4.3 0.016 15.2 4.3 1.3 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 OmpH PF03938.14 EFO61537.1 - 0.0097 16.2 1.6 0.014 15.7 1.6 1.2 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) SLATT_3 PF18184.1 EFO61537.1 - 0.015 15.4 0.6 0.024 14.8 0.6 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 3 BRE1 PF08647.11 EFO61537.1 - 0.017 15.1 2.9 0.032 14.3 2.9 1.4 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase DUF1043 PF06295.12 EFO61537.1 - 0.023 14.7 0.2 0.035 14.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) NUDE_C PF04880.13 EFO61537.1 - 0.026 15.0 0.9 0.026 15.0 0.9 2.1 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region Spc24 PF08286.11 EFO61537.1 - 0.034 14.4 1.2 0.059 13.6 1.2 1.5 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 USP8_interact PF08941.10 EFO61537.1 - 0.038 13.8 3.8 0.063 13.1 3.7 1.5 1 1 0 1 1 1 0 USP8 interacting zf-C2HC_2 PF13913.6 EFO61537.1 - 0.043 13.7 0.2 0.076 12.9 0.2 1.4 1 0 0 1 1 1 0 zinc-finger of a C2HC-type Vps53_N PF04100.12 EFO61537.1 - 0.046 12.7 2.6 0.06 12.3 2.6 1.1 1 0 0 1 1 1 0 Vps53-like, N-terminal AATF-Che1 PF13339.6 EFO61537.1 - 0.048 14.4 0.4 0.048 14.4 0.4 1.8 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor TFA2_Winged_2 PF18121.1 EFO61537.1 - 0.091 12.5 0.8 0.2 11.4 0.8 1.6 1 0 0 1 1 1 0 TFA2 Winged helix domain 2 LMBR1 PF04791.16 EFO61537.1 - 0.12 11.3 0.1 0.12 11.2 0.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein zf-C3HC4_3 PF13920.6 EFO61537.1 - 0.13 12.2 3.0 0.28 11.1 3.0 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TMPIT PF07851.13 EFO61537.1 - 0.13 11.5 1.2 0.16 11.2 1.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein DASH_Dam1 PF08653.10 EFO61537.1 - 0.13 12.1 2.0 2.4 8.0 0.8 2.3 1 1 1 2 2 2 0 DASH complex subunit Dam1 zf-RING_5 PF14634.6 EFO61537.1 - 0.18 11.8 1.9 0.23 11.5 0.4 1.9 2 0 0 2 2 2 0 zinc-RING finger domain ZapB PF06005.12 EFO61537.1 - 0.2 12.1 5.1 0.31 11.5 5.1 1.4 1 0 0 1 1 1 0 Cell division protein ZapB TMF_DNA_bd PF12329.8 EFO61537.1 - 0.2 11.7 4.7 0.41 10.7 4.7 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF4446 PF14584.6 EFO61537.1 - 0.2 11.6 1.1 0.31 11.0 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) bZIP_1 PF00170.21 EFO61537.1 - 0.21 11.7 3.6 0.54 10.4 3.6 1.7 1 0 0 1 1 1 0 bZIP transcription factor ATG16 PF08614.11 EFO61537.1 - 0.24 11.6 9.0 0.4 10.9 9.0 1.5 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF3450 PF11932.8 EFO61537.1 - 0.25 10.6 5.3 0.37 10.1 5.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) NPV_P10 PF05531.12 EFO61537.1 - 0.27 11.7 3.8 0.64 10.5 3.8 1.6 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein MCPVI PF02993.14 EFO61537.1 - 0.46 10.3 3.0 3 7.6 1.5 2.2 1 1 1 2 2 2 0 Minor capsid protein VI SseC PF04888.12 EFO61537.1 - 0.65 9.5 2.6 0.89 9.1 2.6 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DUF4140 PF13600.6 EFO61537.1 - 0.68 10.4 5.4 0.39 11.2 2.5 2.0 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) WXG100 PF06013.12 EFO61537.1 - 0.73 10.1 3.6 2.9 8.2 3.6 1.8 1 1 0 1 1 1 0 Proteins of 100 residues with WXG SlyX PF04102.12 EFO61537.1 - 0.83 10.3 5.5 3.5 8.3 5.9 1.8 2 0 0 2 2 1 0 SlyX DnaJ PF00226.31 EFO61539.1 - 2.4e-16 59.6 0.2 4.2e-16 58.8 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain Mod_r PF07200.13 EFO61540.1 - 0.0024 18.0 13.5 0.0024 18.0 13.5 5.2 2 2 3 5 5 5 1 Modifier of rudimentary (Mod(r)) protein NPV_P10 PF05531.12 EFO61540.1 - 0.47 11.0 18.1 1.6 9.3 0.1 5.1 5 0 0 5 5 5 0 Nucleopolyhedrovirus P10 protein HisKA PF00512.25 EFO61540.1 - 2.2 8.4 10.2 0.37 10.9 0.8 3.8 3 0 0 3 3 3 0 His Kinase A (phospho-acceptor) domain ATPase PF06745.13 EFO61540.1 - 3.6 6.9 9.4 0.074 12.4 0.7 2.5 3 0 0 3 3 3 0 KaiC ThiS PF02597.20 EFO61540.1 - 6 7.6 9.8 6.1 7.6 2.5 3.4 2 2 0 2 2 2 0 ThiS family Cnn_1N PF07989.11 EFO61540.1 - 6 7.1 36.5 1.4 9.2 1.8 6.2 5 2 0 5 5 5 0 Centrosomin N-terminal motif 1 Ank_2 PF12796.7 EFO61541.1 - 9.2e-29 99.9 5.2 6.9e-08 33.0 0.1 4.1 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EFO61541.1 - 2.8e-20 71.8 1.0 0.0018 18.7 0.0 6.3 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 EFO61541.1 - 1.2e-19 68.3 0.8 0.13 12.9 0.0 6.3 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.6 EFO61541.1 - 1.1e-15 57.4 8.2 0.008 16.5 0.2 6.0 3 1 3 6 6 6 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61541.1 - 2.1e-15 56.9 3.9 1.5e-06 28.7 0.1 5.6 4 2 2 6 6 6 5 Ankyrin repeats (many copies) Radial_spoke PF04712.12 EFO61543.1 - 1.3e-56 192.6 2.4 4.4e-48 164.4 0.1 4.1 3 1 1 4 4 4 2 Radial spokehead-like protein Ank_2 PF12796.7 EFO61545.1 - 1.2e-31 109.2 0.0 6.6e-12 45.9 0.1 5.1 2 2 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO61545.1 - 1.9e-18 64.6 1.2 0.021 15.4 0.0 7.4 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 EFO61545.1 - 4.1e-18 65.2 0.0 5.1e-05 23.5 0.0 4.8 3 2 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO61545.1 - 1.8e-17 62.9 1.7 0.058 13.9 0.0 6.8 7 0 0 7 7 7 5 Ankyrin repeat Ank_4 PF13637.6 EFO61545.1 - 3.5e-16 59.3 1.7 0.0032 18.0 0.0 6.6 5 2 1 6 6 6 5 Ankyrin repeats (many copies) Sep15_SelM PF08806.11 EFO61546.1 - 0.0033 17.6 0.0 0.0042 17.2 0.0 1.1 1 0 0 1 1 1 1 Sep15/SelM redox domain Mur_ligase_C PF02875.21 EFO61546.1 - 0.12 12.7 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain CCDC-167 PF15188.6 EFO61548.1 - 1.2 9.6 5.1 3 8.3 5.1 1.7 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 TGT PF01702.18 EFO61549.1 - 8.1e-17 61.4 0.0 1.6e-11 44.0 0.0 2.2 2 0 0 2 2 2 2 Queuine tRNA-ribosyltransferase FAINT PF04385.15 EFO61549.1 - 0.03 14.4 0.1 0.059 13.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function, DUF529 Cytochrom_B561 PF03188.16 EFO61549.1 - 0.036 14.2 1.6 0.32 11.1 0.3 2.2 2 0 0 2 2 2 0 Eukaryotic cytochrome b561 Kinesin PF00225.23 EFO61550.1 - 9.8e-91 304.1 0.1 3.3e-90 302.4 0.1 1.9 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFO61550.1 - 3.7e-17 62.7 0.0 7.3e-13 48.7 0.0 3.2 1 1 1 2 2 2 2 Microtubule binding HALZ PF02183.18 EFO61550.1 - 0.024 14.9 10.2 0.16 12.2 5.0 2.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper APG6_N PF17675.1 EFO61550.1 - 1.7 9.2 34.1 0.55 10.8 5.8 3.8 3 0 0 3 3 3 0 Apg6 coiled-coil region OSTbeta PF15048.6 EFO61550.1 - 4.9 7.3 7.8 23 5.1 0.3 3.1 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein UQ_con PF00179.26 EFO61551.1 - 6.9e-12 45.2 0.0 8.9e-12 44.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme TACC_C PF05010.14 EFO61552.1 - 9.5 6.0 9.5 5.6 6.7 4.6 2.8 2 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal PHF5 PF03660.14 EFO61553.1 - 6.7e-20 71.2 15.3 7.8e-20 71.0 15.3 1.0 1 0 0 1 1 1 1 PHF5-like protein CEBP_ZZ PF16366.5 EFO61553.1 - 0.019 15.2 4.1 0.019 15.2 4.1 2.4 1 1 1 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Ribosomal_L1 PF00687.21 EFO61554.1 - 1.6e-38 132.5 1.0 1.7e-38 132.4 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family HU-CCDC81_euk_2 PF18289.1 EFO61555.1 - 1.5e-09 37.9 0.1 4.8e-09 36.2 0.0 1.8 2 0 0 2 2 2 1 CCDC81 eukaryotic HU domain 2 HU-CCDC81_euk_1 PF14908.6 EFO61555.1 - 0.0017 18.5 0.0 0.0083 16.3 0.0 2.2 1 1 0 1 1 1 1 CCDC81 eukaryotic HU domain 1 DUF2000 PF09391.10 EFO61555.1 - 0.47 10.4 2.5 0.69 9.8 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2000) Cytochrom_C PF00034.21 EFO61555.1 - 2.8 9.1 9.2 62 4.8 9.2 3.1 1 1 0 1 1 1 0 Cytochrome c Ribosomal_S4 PF00163.19 EFO61555.1 - 3.4 8.7 7.8 8.7 7.3 2.3 2.7 2 0 0 2 2 2 0 Ribosomal protein S4/S9 N-terminal domain EF-hand_1 PF00036.32 EFO61556.1 - 1.9e-31 105.2 16.3 4.4e-09 35.2 1.0 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EFO61556.1 - 1.4e-29 102.3 9.5 2.7e-14 53.3 0.3 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFO61556.1 - 2.4e-25 86.3 8.8 1.2e-08 34.2 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EFO61556.1 - 1.5e-24 85.6 15.4 1.5e-12 47.2 1.5 3.9 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 EFO61556.1 - 6.1e-17 61.7 0.1 3.1e-07 30.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EFO61556.1 - 2.2e-12 45.8 19.7 1.7e-05 24.1 0.2 4.9 4 1 1 5 5 5 3 EF hand EF-hand_4 PF12763.7 EFO61556.1 - 6.3e-05 22.9 5.0 0.056 13.4 0.8 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 EFO61556.1 - 0.00028 21.2 1.2 0.46 10.9 0.2 2.3 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EFO61556.1 - 0.0045 17.3 0.7 0.41 11.0 0.4 2.1 1 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region SurA_N_3 PF13624.6 EFO61556.1 - 0.0098 15.7 1.0 0.33 10.7 0.4 2.1 1 1 1 2 2 2 1 SurA N-terminal domain SurA_N_2 PF13623.6 EFO61556.1 - 0.014 15.3 0.2 0.43 10.5 0.1 2.3 2 0 0 2 2 2 0 SurA N-terminal domain Dockerin_1 PF00404.18 EFO61556.1 - 0.023 14.9 0.4 0.6 10.3 0.1 2.4 2 1 0 2 2 2 0 Dockerin type I domain DUF853 PF05872.12 EFO61556.1 - 0.042 12.5 0.1 2.5 6.6 0.0 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF853) SUB1_ProdP9 PF18213.1 EFO61556.1 - 0.059 13.2 1.1 0.093 12.6 0.5 1.7 2 0 0 2 2 2 0 SUB1 protease Prodomain ProdP9 DUF3911 PF13050.6 EFO61556.1 - 0.075 13.2 0.9 0.56 10.4 0.2 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3911) DUF3349 PF11829.8 EFO61556.1 - 0.082 13.7 0.6 15 6.4 0.1 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF3349) Arc_PepC PF06819.11 EFO61556.1 - 0.089 12.9 1.8 0.12 12.5 1.4 1.5 1 1 0 1 1 1 0 Archaeal Peptidase A24 C-terminal Domain Caleosin PF05042.13 EFO61556.1 - 0.1 12.5 0.3 1.6 8.7 0.3 2.8 1 1 1 2 2 2 0 Caleosin related protein SRI PF08236.11 EFO61556.1 - 0.11 12.6 1.1 0.94 9.7 0.2 2.5 2 1 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain EF-hand_11 PF08976.11 EFO61556.1 - 0.14 13.0 0.3 4.9 8.1 0.1 2.1 1 1 1 2 2 2 0 EF-hand domain DUF21 PF01595.20 EFO61556.1 - 0.35 10.6 0.6 1.1 9.0 0.2 1.9 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain MazG PF03819.17 EFO61556.1 - 1.7 8.9 6.1 21 5.4 0.0 3.1 2 1 1 3 3 3 0 MazG nucleotide pyrophosphohydrolase domain DUF2070 PF09843.9 EFO61557.1 - 6.4 4.9 6.0 8.2 4.6 6.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Malic_M PF03949.15 EFO61558.1 - 3.9e-93 311.4 0.0 5e-93 311.1 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EFO61558.1 - 4.1e-60 202.7 0.0 6.2e-60 202.1 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain DivIC PF04977.15 EFO61558.1 - 0.15 11.9 0.0 5.6 6.8 0.0 2.4 2 0 0 2 2 2 0 Septum formation initiator 5_nucleotid_C PF02872.18 EFO61561.1 - 3.7e-07 30.5 0.0 1.1e-06 29.0 0.0 1.7 2 0 0 2 2 2 1 5'-nucleotidase, C-terminal domain CLASP_N PF12348.8 EFO61562.1 - 4.4e-15 55.9 0.5 1.4e-07 31.3 0.6 2.5 2 0 0 2 2 2 2 CLASP N terminal HEAT PF02985.22 EFO61562.1 - 2.6e-10 39.6 6.4 0.015 15.5 0.0 6.6 8 0 0 8 8 8 2 HEAT repeat HEAT_2 PF13646.6 EFO61562.1 - 1.9e-08 34.6 1.1 0.00027 21.3 0.1 4.3 5 0 0 5 5 5 2 HEAT repeats HEAT_EZ PF13513.6 EFO61562.1 - 1.2e-06 28.9 0.9 0.024 15.1 0.0 5.2 4 2 1 5 5 5 1 HEAT-like repeat Arm PF00514.23 EFO61562.1 - 2.7e-06 27.2 0.4 0.043 13.9 0.0 5.4 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 EFO61562.1 - 0.00013 20.7 1.8 0.041 12.4 0.0 3.6 3 0 0 3 3 3 1 Adaptin N terminal region Cnd1 PF12717.7 EFO61562.1 - 0.0063 16.6 7.5 0.14 12.2 0.1 5.1 5 2 1 7 7 7 1 non-SMC mitotic condensation complex subunit 1 Rotavirus_VP1 PF12289.8 EFO61562.1 - 0.0093 15.0 0.2 0.016 14.3 0.2 1.2 1 0 0 1 1 1 1 Rotavirus VP1 C-terminal domain DUF3385 PF11865.8 EFO61562.1 - 0.11 12.4 0.0 3.3 7.6 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) DHHC PF01529.20 EFO61563.1 - 9.3e-31 106.7 10.4 9.3e-31 106.7 10.4 2.6 3 0 0 3 3 3 1 DHHC palmitoyltransferase DNA_RNApol_7kD PF03604.13 EFO61563.1 - 4.8 7.0 10.5 4.5 7.0 0.1 3.0 2 1 1 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit Pkinase PF00069.25 EFO61564.1 - 8.7e-58 195.8 0.0 1.4e-57 195.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EFO61564.1 - 2.8e-31 107.9 2.1 2.7e-11 43.9 0.0 3.8 2 1 2 4 4 3 3 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EFO61564.1 - 2.2e-26 92.7 0.0 4.1e-26 91.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_4 PF13637.6 EFO61564.1 - 2.6e-22 78.9 0.3 1.2e-08 35.3 0.0 4.6 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61564.1 - 8.8e-20 68.7 1.0 0.0015 18.8 0.0 6.5 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 EFO61564.1 - 1.9e-18 66.3 2.9 0.00032 20.9 0.1 5.9 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO61564.1 - 2.5e-18 65.6 0.4 0.00014 22.1 0.1 6.7 7 0 0 7 7 6 4 Ankyrin repeat Kinase-like PF14531.6 EFO61564.1 - 3.2e-06 26.7 0.0 5.1e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFO61564.1 - 0.00052 18.9 0.0 0.00089 18.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFO61564.1 - 0.00059 19.8 0.0 0.0031 17.5 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family YjhX_toxin PF09857.9 EFO61564.1 - 0.029 14.3 0.0 0.092 12.7 0.0 1.8 1 0 0 1 1 1 0 Putative toxin of bacterial toxin-antitoxin pair DUF2179 PF10035.9 EFO61564.1 - 0.15 11.8 0.1 0.4 10.5 0.1 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2179) ANAPC4_WD40 PF12894.7 EFO61566.1 - 0.013 15.8 0.0 0.26 11.6 0.0 3.2 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Fucose_iso_C PF02952.17 EFO61566.1 - 0.016 14.9 0.0 0.041 13.6 0.0 1.6 1 0 0 1 1 1 0 L-fucose isomerase, C-terminal domain WD40 PF00400.32 EFO61566.1 - 0.66 10.9 13.3 16 6.6 0.0 6.8 8 0 0 8 8 8 0 WD domain, G-beta repeat PSK_trans_fac PF07704.11 EFO61566.1 - 2 9.2 7.1 33 5.3 0.8 3.8 2 0 0 2 2 2 0 Rv0623-like transcription factor Lyase_8 PF02278.18 EFO61567.1 - 4.9e-10 39.3 3.1 5.2e-10 39.2 1.1 2.0 3 0 0 3 3 3 1 Polysaccharide lyase family 8, super-sandwich domain Lyase_8_N PF08124.11 EFO61567.1 - 8.3e-08 31.5 0.2 5.3e-07 28.9 0.0 2.0 2 0 0 2 2 2 1 Polysaccharide lyase family 8, N terminal alpha-helical domain Mfa_like_1 PF13149.6 EFO61567.1 - 0.0014 18.7 1.1 0.003 17.6 1.1 1.5 1 0 0 1 1 1 1 Fimbrillin-like DUF3377 PF11857.8 EFO61567.1 - 0.0045 16.9 2.0 0.0045 16.9 2.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3377) REF PF05755.12 EFO61567.1 - 0.12 12.1 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 Rubber elongation factor protein (REF) DEAD PF00270.29 EFO61568.1 - 2.3e-40 138.2 1.4 2.6e-40 138.0 0.3 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO61568.1 - 7.7e-16 58.4 0.0 7.8e-15 55.2 0.0 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFO61568.1 - 2.4e-15 56.5 0.0 5.5e-15 55.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EFO61568.1 - 3e-05 24.1 0.1 8.3e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EFO61568.1 - 0.03 13.0 0.1 0.12 11.1 0.1 1.8 1 1 0 1 1 1 0 SNF2 family N-terminal domain EGF_2 PF07974.13 EFO61569.1 - 6.9e-19 67.9 148.9 0.0017 18.7 7.0 13.8 11 3 2 13 13 13 11 EGF-like domain EGF PF00008.27 EFO61569.1 - 7.8e-05 22.9 17.7 0.00052 20.3 2.7 14.7 14 1 0 14 14 14 5 EGF-like domain FXa_inhibition PF14670.6 EFO61569.1 - 0.0054 17.0 4.4 0.0054 17.0 4.4 12.6 7 4 4 11 11 11 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 EFO61569.1 - 0.0089 16.2 7.6 0.0089 16.2 7.6 12.4 7 5 4 11 11 11 3 Calcium-binding EGF domain hEGF PF12661.7 EFO61569.1 - 0.013 16.1 3.5 0.013 16.1 3.5 16.3 17 4 1 18 18 18 0 Human growth factor-like EGF ANAPC4_WD40 PF12894.7 EFO61570.1 - 0.011 16.0 0.0 0.12 12.6 0.0 2.8 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain ASH PF15780.5 EFO61571.1 - 4.5e-19 68.5 16.6 0.99 9.7 0.1 14.5 13 1 0 13 13 13 7 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 EFO61571.1 - 1e-09 38.4 0.5 0.00039 20.5 0.0 5.9 7 0 0 7 7 7 2 Flagellar-associated PapD-like Motile_Sperm PF00635.26 EFO61571.1 - 1.1e-08 34.9 14.4 0.24 11.3 0.0 7.5 7 0 0 7 7 7 4 MSP (Major sperm protein) domain TMEM131_like PF12371.8 EFO61571.1 - 1.3e-05 25.3 19.2 0.19 12.0 0.1 9.0 9 0 0 9 9 9 2 Transmembrane protein 131-like VWD PF00094.25 EFO61574.1 - 0.0034 17.7 0.2 0.012 15.8 0.2 2.0 1 0 0 1 1 1 1 von Willebrand factor type D domain ADIP PF11559.8 EFO61575.1 - 1.3e-07 31.8 7.0 1.3e-07 31.8 7.0 3.0 3 0 0 3 3 3 1 Afadin- and alpha -actinin-Binding Jnk-SapK_ap_N PF09744.9 EFO61575.1 - 0.0034 17.6 8.9 0.0034 17.6 8.9 2.9 2 1 1 3 3 3 1 JNK_SAPK-associated protein-1 SOGA PF11365.8 EFO61575.1 - 0.012 16.8 4.8 0.012 16.8 4.8 3.4 2 1 0 2 2 2 0 Protein SOGA RACo_linker PF17650.1 EFO61575.1 - 0.064 13.1 0.4 0.92 9.4 0.1 2.8 2 0 0 2 2 2 0 RACo linker region YabA PF06156.13 EFO61575.1 - 0.12 13.0 15.5 0.15 12.7 0.0 3.6 2 2 2 4 4 4 0 Initiation control protein YabA Noelin-1 PF12308.8 EFO61575.1 - 5.5 7.0 18.1 0.77 9.8 5.6 3.5 3 0 0 3 3 3 0 Neurogenesis glycoprotein Ank_2 PF12796.7 EFO61576.1 - 2.9e-117 383.5 49.8 2.3e-16 60.1 0.1 9.1 1 1 11 12 12 12 12 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO61576.1 - 6e-55 176.8 22.6 0.00025 21.2 0.0 16.3 16 0 0 16 16 16 12 Ankyrin repeat Ank PF00023.30 EFO61576.1 - 2.8e-49 163.5 27.2 0.0021 18.4 0.1 15.4 14 2 2 16 16 16 12 Ankyrin repeat Ank_5 PF13857.6 EFO61576.1 - 8.2e-49 163.0 31.2 0.00082 19.6 0.1 15.6 3 3 13 16 16 16 13 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61576.1 - 1.8e-46 155.9 27.1 7.8e-07 29.5 1.4 11.5 8 3 5 13 13 12 11 Ankyrin repeats (many copies) CEP63 PF17045.5 EFO61576.1 - 0.015 15.3 3.6 0.024 14.5 3.6 1.2 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa Spc7 PF08317.11 EFO61576.1 - 0.017 14.0 4.4 0.027 13.4 4.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein HMMR_N PF15905.5 EFO61576.1 - 0.017 14.6 7.3 0.026 14.0 7.3 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal FAM76 PF16046.5 EFO61576.1 - 0.037 13.4 0.3 0.069 12.5 0.3 1.4 1 0 0 1 1 1 0 FAM76 protein Atg14 PF10186.9 EFO61576.1 - 0.046 12.8 3.6 0.076 12.1 3.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RasGAP_C PF03836.15 EFO61576.1 - 0.22 11.7 2.9 0.48 10.6 2.9 1.5 1 0 0 1 1 1 0 RasGAP C-terminus Fez1 PF06818.15 EFO61576.1 - 0.35 11.3 4.0 0.67 10.4 4.0 1.4 1 0 0 1 1 1 0 Fez1 DUF724 PF05266.14 EFO61576.1 - 0.6 9.9 3.8 1.1 9.1 3.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Ank_2 PF12796.7 EFO61577.1 - 1.6e-65 217.6 28.8 3.4e-11 43.6 1.9 11.1 5 3 6 12 12 12 9 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61577.1 - 1.2e-36 124.3 29.9 0.00085 19.6 0.0 13.9 7 3 8 15 15 15 9 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61577.1 - 3.9e-32 110.2 17.2 0.00011 22.7 0.2 11.0 8 3 3 12 12 12 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61577.1 - 1.9e-27 92.2 30.4 0.033 14.7 0.0 16.6 16 1 1 17 17 17 9 Ankyrin repeat Ank PF00023.30 EFO61577.1 - 2.3e-26 91.0 29.2 0.0017 18.7 0.1 14.4 12 3 2 14 14 14 9 Ankyrin repeat Pkinase PF00069.25 EFO61577.1 - 0.00046 19.6 0.0 0.00091 18.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain HAUS-augmin3 PF14932.6 EFO61581.1 - 2.2 7.8 12.2 1.3 8.5 10.0 1.7 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 Nup54 PF13874.6 EFO61581.1 - 5.8 7.0 10.6 2.8 8.0 7.2 2.0 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Thioredoxin_8 PF13905.6 EFO61583.1 - 8.2e-09 35.7 0.0 1.2e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 EFO61583.1 - 1.1e-08 34.9 0.1 9.2e-07 28.8 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin AhpC-TSA PF00578.21 EFO61583.1 - 2.4e-08 33.9 0.0 2.8e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFO61583.1 - 1.2e-07 31.5 0.0 1.4e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 Redoxin Thioredoxin_9 PF14595.6 EFO61583.1 - 6.1e-05 22.8 0.0 0.33 10.7 0.1 2.4 1 1 1 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 EFO61583.1 - 0.019 15.4 0.0 0.026 14.9 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain DUF3662 PF12401.8 EFO61583.1 - 0.18 12.2 0.0 0.26 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2662) ThiF PF00899.21 EFO61584.1 - 6.3e-41 140.3 0.0 8e-41 140.0 0.0 1.1 1 0 0 1 1 1 1 ThiF family UNC-50 PF05216.13 EFO61584.1 - 0.059 12.9 0.9 0.098 12.2 0.9 1.3 1 0 0 1 1 1 0 UNC-50 family XRCC1_N PF01834.16 EFO61585.1 - 0.04 13.9 0.0 0.18 11.8 0.0 2.0 2 0 0 2 2 2 0 XRCC1 N terminal domain F5_F8_type_C PF00754.25 EFO61585.1 - 0.051 13.7 0.1 0.17 12.0 0.0 1.9 2 0 0 2 2 2 0 F5/8 type C domain UVR PF02151.19 EFO61585.1 - 1 9.2 7.9 7.3 6.5 1.5 2.8 2 0 0 2 2 2 0 UvrB/uvrC motif Transglut_core PF01841.19 EFO61587.1 - 1.4e-07 32.0 0.0 2.8e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily TssN PF17555.2 EFO61589.1 - 0.31 10.4 5.3 0.41 10.0 5.3 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssN DUF4231 PF14015.6 EFO61589.1 - 1 9.8 4.8 12 6.4 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) PQ-loop PF04193.14 EFO61590.1 - 6.1e-23 80.4 19.7 2e-12 46.7 5.2 3.3 3 0 0 3 3 3 2 PQ loop repeat YfdX PF10938.8 EFO61594.1 - 0.029 14.3 0.7 0.048 13.6 0.1 1.6 2 0 0 2 2 2 0 YfdX protein DUF1104 PF06518.11 EFO61594.1 - 0.073 13.5 1.0 6.7 7.2 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1104) DUF4201 PF13870.6 EFO61595.1 - 2.7e-05 24.0 3.6 2.7e-05 24.0 3.6 6.4 6 2 1 7 7 7 3 Domain of unknown function (DUF4201) HAP1_N PF04849.13 EFO61595.1 - 0.0016 17.7 8.1 0.0016 17.7 8.1 5.0 5 1 0 6 6 6 2 HAP1 N-terminal conserved region Fez1 PF06818.15 EFO61595.1 - 0.0034 17.9 45.5 0.16 12.4 7.0 5.6 3 1 0 4 4 4 2 Fez1 ATG16 PF08614.11 EFO61595.1 - 0.005 17.1 10.9 0.005 17.1 10.9 6.1 3 2 1 5 5 5 3 Autophagy protein 16 (ATG16) TMF_DNA_bd PF12329.8 EFO61595.1 - 0.09 12.8 67.6 0.023 14.7 2.5 8.9 6 3 2 8 8 8 0 TATA element modulatory factor 1 DNA binding XPC-binding PF09280.11 EFO61595.1 - 0.42 10.4 3.1 1.2 8.9 0.3 3.1 2 0 0 2 2 2 0 XPC-binding domain SlyX PF04102.12 EFO61595.1 - 2.3 8.9 43.1 0.49 11.1 1.2 8.5 7 2 1 8 8 8 0 SlyX MetOD2 PF18548.1 EFO61595.1 - 3.7 7.7 16.5 2.8 8.1 2.0 4.6 3 0 0 3 3 3 0 Metanogen output domain 2 DUF572 PF04502.13 EFO61596.1 - 8.5e-05 22.3 1.2 0.0001 22.1 1.2 1.4 1 1 0 1 1 1 1 Family of unknown function (DUF572) CpXC PF14353.6 EFO61596.1 - 0.03 14.4 0.9 0.16 12.0 0.0 2.0 1 1 1 2 2 2 0 CpXC protein PknG_rubred PF16919.5 EFO61596.1 - 0.089 13.0 1.0 0.14 12.3 0.4 1.6 2 0 0 2 2 2 0 Protein kinase G rubredoxin domain zf-ribbon_3 PF13248.6 EFO61596.1 - 0.2 11.1 1.9 5 6.7 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2HC5 PF06221.13 EFO61596.1 - 0.32 11.0 2.3 2.3 8.3 2.3 2.0 1 1 0 1 1 1 0 Putative zinc finger motif, C2HC5-type zf-C2H2 PF00096.26 EFO61596.1 - 0.32 11.6 2.0 7.9 7.2 0.3 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF4988 PF16378.5 EFO61597.1 - 0.00031 20.5 0.4 0.00031 20.5 0.4 2.2 2 0 0 2 2 2 1 Domain of unknown function UCH PF00443.29 EFO61597.1 - 0.00097 18.7 2.6 0.0012 18.4 2.6 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Lebercilin PF15619.6 EFO61597.1 - 0.003 17.2 8.0 0.003 17.2 8.0 2.3 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease Uso1_p115_C PF04871.13 EFO61597.1 - 0.019 15.3 8.1 0.52 10.7 2.1 2.5 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region FlaC_arch PF05377.11 EFO61597.1 - 0.029 14.8 9.3 0.72 10.3 1.4 3.0 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 EFO61597.1 - 0.04 14.0 13.5 0.07 13.2 1.6 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) UTP15_C PF09384.10 EFO61597.1 - 0.045 13.4 0.2 0.045 13.4 0.2 2.3 2 1 1 3 3 3 0 UTP15 C terminal Spc7 PF08317.11 EFO61597.1 - 0.054 12.4 16.0 0.021 13.7 3.7 2.3 1 1 0 2 2 2 0 Spc7 kinetochore protein GCN5L1 PF06320.13 EFO61597.1 - 0.077 13.2 0.5 0.077 13.2 0.5 2.8 3 1 0 3 3 2 0 GCN5-like protein 1 (GCN5L1) Snapin_Pallidin PF14712.6 EFO61597.1 - 0.097 13.1 13.6 1 9.8 1.3 4.2 3 1 1 4 4 4 0 Snapin/Pallidin ATG16 PF08614.11 EFO61597.1 - 0.17 12.1 13.9 0.71 10.1 3.8 2.5 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF1515 PF07439.11 EFO61597.1 - 0.25 11.4 7.1 0.089 12.8 0.4 3.2 2 2 1 3 3 3 0 Protein of unknown function (DUF1515) DUF2730 PF10805.8 EFO61597.1 - 0.3 11.2 11.6 0.63 10.2 1.2 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) Syntaxin_2 PF14523.6 EFO61597.1 - 0.36 11.2 18.9 7.5 7.0 3.8 3.7 1 1 2 3 3 3 0 Syntaxin-like protein ZapB PF06005.12 EFO61597.1 - 0.52 10.8 13.5 1.4 9.4 2.3 2.9 2 2 0 2 2 2 0 Cell division protein ZapB BLOC1_2 PF10046.9 EFO61597.1 - 0.57 10.5 12.1 0.14 12.5 0.9 3.3 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fib_alpha PF08702.10 EFO61597.1 - 0.69 10.1 16.0 0.11 12.7 4.8 3.0 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family LPP PF04728.13 EFO61597.1 - 0.75 10.2 4.2 3.3 8.2 0.2 3.7 3 1 1 4 4 4 0 Lipoprotein leucine-zipper XhlA PF10779.9 EFO61597.1 - 1.1 9.5 10.9 0.64 10.3 2.5 3.1 2 1 0 2 2 2 0 Haemolysin XhlA DASH_Dam1 PF08653.10 EFO61597.1 - 1.4 8.8 3.9 3 7.7 0.3 3.3 3 0 0 3 3 3 0 DASH complex subunit Dam1 CREPT PF16566.5 EFO61597.1 - 1.9 8.6 9.2 0.5 10.5 1.4 2.7 2 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour Cytochrom_B562 PF07361.11 EFO61597.1 - 1.9 9.2 7.8 5.6 7.7 0.6 3.6 1 1 3 4 4 4 0 Cytochrome b562 Laminin_II PF06009.12 EFO61597.1 - 2 8.4 14.1 1.1 9.3 2.4 3.0 2 1 1 3 3 3 0 Laminin Domain II DUF4477 PF14780.6 EFO61597.1 - 2.4 7.7 5.3 7.4 6.1 1.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4477) Tho2 PF11262.8 EFO61597.1 - 2.5 7.2 7.8 0.36 10.0 1.9 2.1 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 PhaP_Bmeg PF09602.10 EFO61597.1 - 2.5 8.0 10.3 1.9 8.4 1.1 2.9 1 1 2 3 3 3 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) TolA_bind_tri PF16331.5 EFO61597.1 - 2.7 8.2 7.5 4.9 7.3 1.3 3.3 2 1 1 3 3 3 0 TolA binding protein trimerisation KxDL PF10241.9 EFO61597.1 - 2.7 8.3 10.8 4.1 7.7 2.0 3.2 3 0 0 3 3 3 0 Uncharacterized conserved protein DUF16 PF01519.16 EFO61597.1 - 3.1 8.3 15.9 0.14 12.6 3.9 3.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 GIT_CC PF16559.5 EFO61597.1 - 3.2 7.7 8.2 5 7.1 1.1 3.3 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DivIC PF04977.15 EFO61597.1 - 3.3 7.6 8.7 5.9 6.7 0.6 3.4 2 1 1 3 3 3 0 Septum formation initiator DUF641 PF04859.12 EFO61597.1 - 8.6 6.7 7.9 1.7 9.0 1.8 2.4 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) NPV_P10 PF05531.12 EFO61597.1 - 9.7 6.7 14.1 0.63 10.5 3.7 3.6 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein IMS PF00817.20 EFO61598.1 - 4.3e-41 140.4 0.1 1.2e-40 138.9 0.1 1.8 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 EFO61598.1 - 6e-11 43.1 0.0 9.4e-10 39.2 0.0 2.6 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EFO61598.1 - 0.06 13.7 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 IMS family HHH motif SUFU PF05076.13 EFO61598.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Suppressor of fused protein (SUFU) Myb_DNA-binding PF00249.31 EFO61599.1 - 1.7e-21 76.1 0.2 3.3e-10 40.0 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFO61599.1 - 7.9e-17 61.3 1.0 2.8e-13 49.9 0.3 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EFO61599.1 - 0.087 13.2 0.6 0.83 10.1 0.1 2.5 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain Pkinase PF00069.25 EFO61600.1 - 1.1e-58 198.8 0.0 1.4e-58 198.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61600.1 - 1.8e-37 129.0 0.0 2.5e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO61600.1 - 8.5e-11 42.3 0.4 3.8e-09 37.0 0.2 3.2 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61600.1 - 1.5e-06 28.3 0.0 0.13 12.6 0.1 3.6 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61600.1 - 1.1e-05 25.9 0.0 0.0014 19.2 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Kinase-like PF14531.6 EFO61600.1 - 0.00018 21.0 0.0 0.00027 20.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Ank PF00023.30 EFO61600.1 - 0.00048 20.4 0.0 0.69 10.5 0.0 3.4 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 EFO61600.1 - 0.0021 18.4 0.0 2.7 8.8 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeat EIIBC-GUT_C PF07663.11 EFO61600.1 - 0.1 12.8 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II C-terminus MatE PF01554.18 EFO61601.1 - 6.2e-08 32.5 30.5 5.1e-05 23.0 7.5 3.5 2 2 1 3 3 3 2 MatE FYVE PF01363.21 EFO61602.1 - 1.1e-16 60.8 10.5 1.9e-16 60.0 10.5 1.3 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 EFO61602.1 - 0.065 13.4 7.0 0.14 12.4 7.0 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger ATPgrasp_Ter PF15632.6 EFO61602.1 - 0.12 12.1 0.1 0.26 11.0 0.1 1.5 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon IBR PF01485.21 EFO61602.1 - 0.43 10.9 7.1 1 9.6 7.1 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf_C2HC_14 PF18574.1 EFO61602.1 - 0.45 10.3 2.5 1 9.2 2.5 1.5 1 0 0 1 1 1 0 C2HC Zing finger domain Pre-PUA PF17832.1 EFO61603.1 - 1e-13 51.7 0.0 1.8e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EFO61603.1 - 4.7e-06 26.5 0.0 7.5e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 PUA domain Ribosomal_S13_N PF08069.12 EFO61604.1 - 9.5e-27 92.8 0.0 1.9e-26 91.9 0.0 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 EFO61604.1 - 9.5e-13 48.2 0.6 1.4e-12 47.6 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S15 CDC73_C PF05179.14 EFO61605.1 - 5.1e-25 88.0 0.1 1.1e-24 86.9 0.1 1.6 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal Coatomer_WDAD PF04053.14 EFO61606.1 - 1.5e-26 93.5 1.9 2.4e-20 73.0 0.1 4.6 3 2 0 3 3 3 2 Coatomer WD associated region WD40 PF00400.32 EFO61606.1 - 3.8e-25 87.7 9.8 5.7e-05 23.8 0.2 7.9 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO61606.1 - 2e-11 44.0 0.3 0.31 11.4 0.0 7.1 6 2 2 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFO61606.1 - 0.0011 18.4 0.4 0.91 8.8 0.0 3.0 3 0 0 3 3 3 2 WD40-like domain UspB PF10625.9 EFO61606.1 - 0.12 12.3 0.0 0.31 11.0 0.0 1.6 1 0 0 1 1 1 0 Universal stress protein B (UspB) STI1 PF17830.1 EFO61607.1 - 3.7e-14 52.4 0.5 7.2e-14 51.5 0.5 1.4 1 0 0 1 1 1 1 STI1 domain TPR_1 PF00515.28 EFO61607.1 - 3.3e-08 33.0 1.1 0.0025 17.6 2.2 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFO61607.1 - 1.8e-06 27.6 2.0 0.01 15.5 0.0 3.5 1 1 2 3 3 3 2 TPR repeat TPR_2 PF07719.17 EFO61607.1 - 2.5e-05 24.0 2.4 0.0018 18.2 2.1 4.1 5 0 0 5 5 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFO61607.1 - 5.2e-05 23.4 1.4 0.00015 21.9 1.1 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EFO61607.1 - 9.7e-05 22.3 0.8 0.47 10.8 0.0 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFO61607.1 - 0.00013 22.2 6.7 0.00031 21.0 2.6 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat BTAD PF03704.17 EFO61607.1 - 0.00088 19.7 2.9 0.00088 19.7 2.9 2.2 2 2 0 2 2 2 1 Bacterial transcriptional activator domain TPR_16 PF13432.6 EFO61607.1 - 0.0026 18.4 1.6 0.0026 18.4 1.6 2.8 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFO61607.1 - 0.0054 17.2 9.3 0.0075 16.8 0.4 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFO61607.1 - 0.021 15.0 1.2 0.12 12.5 1.2 2.3 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFO61607.1 - 0.043 14.2 0.3 15 6.2 0.0 3.4 3 1 0 3 3 2 0 Tetratricopeptide repeat Hydrolase PF00702.26 EFO61607.1 - 0.063 13.5 1.2 0.096 13.0 1.2 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase TPR_14 PF13428.6 EFO61607.1 - 0.078 13.8 0.2 0.078 13.8 0.2 4.4 2 1 1 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFO61607.1 - 0.082 13.0 4.8 2.2 8.5 0.6 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat GerD PF17898.1 EFO61607.1 - 0.48 10.4 5.6 0.086 12.8 0.7 2.2 2 1 0 2 2 2 0 Spore germination GerD central core domain DUF1840 PF08895.11 EFO61607.1 - 9.2 6.7 10.1 3.4 8.1 3.5 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1840) PFK PF00365.20 EFO61609.1 - 6.7e-34 117.5 0.0 2.4e-33 115.7 0.0 1.8 1 1 0 1 1 1 1 Phosphofructokinase DUF4370 PF14290.6 EFO61611.1 - 0.082 12.8 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4370) HIP1_clath_bdg PF16515.5 EFO61612.1 - 7.6 7.2 7.9 1.6 9.4 0.6 3.2 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 VSP PF03302.13 EFO61613.1 - 6.7e-92 308.4 151.1 1e-51 176.1 27.3 6.5 1 1 4 5 5 5 4 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO61613.1 - 0.48 10.5 2.5 0.48 10.5 0.1 2.2 2 1 0 2 2 2 0 Podoplanin DUF4521 PF15021.6 EFO61615.1 - 0.0023 17.9 0.2 0.0081 16.1 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4521) Phage_GP20 PF06810.11 EFO61615.1 - 0.0041 16.9 12.7 0.03 14.1 1.8 4.7 2 1 2 4 4 4 1 Phage minor structural protein GP20 DUF4618 PF15397.6 EFO61615.1 - 0.0057 16.1 0.2 0.0057 16.1 0.2 4.1 2 1 0 3 3 3 1 Domain of unknown function (DUF4618) Trns_repr_metal PF02583.17 EFO61615.1 - 0.013 15.9 0.8 0.58 10.6 0.2 3.2 2 0 0 2 2 2 0 Metal-sensitive transcriptional repressor Spc7 PF08317.11 EFO61615.1 - 0.021 13.7 26.7 0.031 13.2 0.7 4.5 3 1 2 5 5 5 0 Spc7 kinetochore protein Mod_r PF07200.13 EFO61615.1 - 0.035 14.2 0.5 0.035 14.2 0.5 5.2 3 1 2 5 5 5 0 Modifier of rudimentary (Mod(r)) protein DUF948 PF06103.11 EFO61615.1 - 0.053 13.8 14.5 0.66 10.3 1.0 4.8 4 1 1 5 5 4 0 Bacterial protein of unknown function (DUF948) FliD_C PF07195.12 EFO61615.1 - 0.28 10.6 24.5 1.6 8.1 0.4 4.7 2 1 0 3 3 3 0 Flagellar hook-associated protein 2 C-terminus DUF2125 PF09898.9 EFO61615.1 - 0.44 10.1 3.3 0.74 9.4 3.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2125) Laminin_II PF06009.12 EFO61615.1 - 0.5 10.4 23.2 0.75 9.8 5.0 4.7 3 1 0 4 4 4 0 Laminin Domain II MCPsignal PF00015.21 EFO61615.1 - 0.59 9.9 14.8 1 9.1 2.8 3.0 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF5082 PF16888.5 EFO61615.1 - 0.74 10.1 21.1 3.2 8.0 0.1 4.6 2 1 2 4 4 4 0 Domain of unknown function (DUF5082) FliD_N PF02465.18 EFO61615.1 - 0.82 10.4 24.2 0.54 11.0 3.8 4.4 3 1 1 4 4 4 0 Flagellar hook-associated protein 2 N-terminus DUF16 PF01519.16 EFO61615.1 - 1.6 9.2 27.0 1.6 9.3 0.1 6.3 3 1 3 6 6 6 0 Protein of unknown function DUF16 BLOC1_2 PF10046.9 EFO61615.1 - 2.1 8.7 21.2 5.3 7.4 2.4 5.5 4 2 0 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tropomyosin_1 PF12718.7 EFO61615.1 - 3.1 7.9 21.6 8.9 6.5 0.6 4.1 2 1 0 3 3 3 0 Tropomyosin like LPP PF04728.13 EFO61615.1 - 3.4 8.1 0.0 3.4 8.1 0.0 5.9 6 1 1 7 7 7 0 Lipoprotein leucine-zipper Cob_adeno_trans PF01923.18 EFO61615.1 - 3.4 7.8 13.6 26 4.9 0.1 5.4 3 2 3 6 6 6 0 Cobalamin adenosyltransferase DNA_pol_B_2 PF03175.13 EFO61616.1 - 3.9e-36 124.9 0.1 6.6e-36 124.2 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral Gal4_dimer PF03902.13 EFO61616.1 - 0.033 14.3 0.1 0.13 12.4 0.1 2.0 1 0 0 1 1 1 0 Gal4-like dimerisation domain dNK PF01712.19 EFO61617.1 - 5e-15 55.9 0.0 6.8e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Deoxynucleoside kinase Thymidylate_kin PF02223.17 EFO61617.1 - 0.00021 21.1 0.0 0.00042 20.0 0.0 1.5 1 1 0 1 1 1 1 Thymidylate kinase CLP1_P PF16575.5 EFO61617.1 - 0.00021 21.2 0.0 0.00032 20.5 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_18 PF13238.6 EFO61617.1 - 0.0012 19.4 0.0 0.0028 18.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFO61617.1 - 0.0055 17.0 0.0 0.0088 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFO61617.1 - 0.01 16.2 0.0 0.018 15.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 EFO61617.1 - 0.016 15.2 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Cytidylate_kin PF02224.18 EFO61617.1 - 0.018 14.8 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_22 PF13401.6 EFO61617.1 - 0.026 14.8 0.0 0.049 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EFO61617.1 - 0.027 14.3 0.0 0.047 13.5 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 EFO61617.1 - 0.033 14.4 0.0 0.21 11.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 EFO61617.1 - 0.071 13.0 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_30 PF13604.6 EFO61617.1 - 0.079 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 EFO61617.1 - 0.082 12.1 0.0 0.082 12.1 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain AAA_24 PF13479.6 EFO61617.1 - 0.099 12.4 0.0 0.18 11.5 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_PrkA PF08298.11 EFO61617.1 - 0.15 11.0 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 PrkA AAA domain RNA_helicase PF00910.22 EFO61617.1 - 0.16 12.3 0.0 0.4 11.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Ank_2 PF12796.7 EFO61620.1 - 4.9e-37 126.4 8.8 1.4e-17 64.0 0.4 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EFO61620.1 - 6.9e-24 83.2 1.3 0.00031 21.1 0.0 6.0 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 EFO61620.1 - 5.1e-21 74.8 3.8 3.7e-05 24.2 0.1 5.0 4 1 0 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61620.1 - 3.1e-19 67.0 2.2 0.021 15.3 0.0 6.0 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EFO61620.1 - 4.1e-18 65.2 10.1 1.8e-05 24.9 0.0 5.6 1 1 5 6 6 6 4 Ankyrin repeats (many copies) VWA_3_C PF18571.1 EFO61620.1 - 0.55 10.1 7.6 7 6.6 0.0 5.0 7 0 0 7 7 7 0 von Willebrand factor type A C-terminal domain DUF4911 PF16256.5 EFO61621.1 - 0.098 12.6 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4911) Pox_C7_F8A PF03287.14 EFO61623.1 - 0.12 12.4 1.6 0.14 12.1 0.2 1.8 2 0 0 2 2 2 0 Poxvirus C7/F8A protein Pox_A32 PF04665.12 EFO61624.1 - 6.7e-06 25.7 2.0 0.00055 19.5 0.1 2.5 1 1 2 3 3 3 1 Poxvirus A32 protein ATPase_2 PF01637.18 EFO61624.1 - 0.00058 19.9 2.6 0.0014 18.6 2.6 1.6 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea Seryl_tRNA_N PF02403.22 EFO61624.1 - 0.00083 19.6 0.3 0.002 18.3 0.3 1.6 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain ResIII PF04851.15 EFO61624.1 - 0.00093 19.2 0.3 0.0015 18.5 0.3 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_16 PF13191.6 EFO61624.1 - 0.00093 19.6 0.2 0.002 18.6 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EFO61624.1 - 0.0013 18.8 0.0 0.003 17.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EFO61624.1 - 0.0024 17.5 0.0 0.0051 16.5 0.0 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain DUF2075 PF09848.9 EFO61624.1 - 0.0025 17.1 0.2 0.008 15.5 0.0 1.9 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EFO61624.1 - 0.0029 17.9 0.2 0.014 15.6 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFO61624.1 - 0.0038 17.8 0.0 0.0087 16.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 EFO61624.1 - 0.0061 15.6 0.4 0.019 14.0 0.1 2.0 1 1 1 2 2 2 1 Type II/IV secretion system protein NB-ARC PF00931.22 EFO61624.1 - 0.0074 15.5 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_19 PF13245.6 EFO61624.1 - 0.0084 16.5 0.0 0.015 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EFO61624.1 - 0.0096 16.4 0.0 0.017 15.7 0.0 1.4 1 1 0 1 1 1 1 ABC transporter G-alpha PF00503.20 EFO61624.1 - 0.014 14.6 0.5 0.17 11.0 0.1 2.0 2 0 0 2 2 2 0 G-protein alpha subunit Viral_helicase1 PF01443.18 EFO61624.1 - 0.028 14.2 0.0 0.066 12.9 0.0 1.8 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_15 PF13175.6 EFO61624.1 - 0.05 13.3 0.1 0.23 11.1 0.0 1.6 1 1 1 2 2 2 0 AAA ATPase domain AAA_28 PF13521.6 EFO61624.1 - 0.064 13.5 0.1 0.16 12.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFO61624.1 - 0.069 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 EFO61624.1 - 0.078 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 EFO61624.1 - 0.1 12.3 0.0 0.26 11.0 0.0 1.6 1 1 1 2 2 2 0 AAA domain CbiA PF01656.23 EFO61624.1 - 0.14 12.2 0.0 0.39 10.8 0.0 1.7 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain cobW PF02492.19 EFO61624.1 - 0.58 9.7 4.0 0.98 9.0 0.3 2.2 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 EFO61624.1 - 0.61 10.1 3.2 1.6 8.8 3.2 1.7 1 1 0 1 1 1 0 Helicase HerA, central domain AAA_23 PF13476.6 EFO61624.1 - 4.1 7.8 10.4 0.61 10.6 1.0 2.2 1 1 0 2 2 2 0 AAA domain FXMR_C2 PF16098.5 EFO61626.1 - 0.098 13.2 0.9 0.19 12.3 0.9 1.5 1 0 0 1 1 1 0 Fragile X-related mental retardation protein C-terminal region 2 TBCA PF02970.16 EFO61627.1 - 0.025 14.9 0.1 0.055 13.8 0.1 1.5 1 0 0 1 1 1 0 Tubulin binding cofactor A KxDL PF10241.9 EFO61627.1 - 0.51 10.7 2.7 1.1 9.6 2.7 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein Tubulin PF00091.25 EFO61629.1 - 3e-68 229.9 0.0 5.1e-68 229.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFO61629.1 - 7.2e-41 139.3 0.0 1e-40 138.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EFO61629.1 - 2.3e-05 24.7 0.0 5.2e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EFO61629.1 - 0.0044 16.7 0.0 0.0087 15.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 EFO61629.1 - 0.0067 15.7 0.2 0.027 13.7 0.0 1.8 2 0 0 2 2 2 1 Tubulin like Peptidase_M20 PF01546.28 EFO61631.1 - 9.3e-14 51.6 0.0 2.4e-13 50.3 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFO61631.1 - 0.0001 22.2 0.0 0.00027 20.8 0.0 1.8 1 1 0 1 1 1 1 Peptidase dimerisation domain Tubulin PF00091.25 EFO61632.1 - 3e-68 229.9 0.0 5.1e-68 229.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFO61632.1 - 7.2e-41 139.3 0.0 1e-40 138.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EFO61632.1 - 2.3e-05 24.7 0.0 5.2e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EFO61632.1 - 0.0044 16.7 0.0 0.0087 15.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 EFO61632.1 - 0.0067 15.7 0.2 0.027 13.7 0.0 1.8 2 0 0 2 2 2 1 Tubulin like AAA_6 PF12774.7 EFO61633.1 - 5.7e-146 485.7 0.1 1.8e-145 484.0 0.1 2.0 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFO61633.1 - 5.3e-123 411.0 7.6 5.3e-123 411.0 7.6 4.4 4 1 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 EFO61633.1 - 6.7e-101 337.5 0.1 2.1e-100 335.9 0.0 2.0 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 EFO61633.1 - 1.2e-83 280.4 0.0 2.9e-83 279.2 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 EFO61633.1 - 7.5e-78 260.6 4.0 3.4e-77 258.5 2.6 3.0 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 EFO61633.1 - 1.7e-73 246.0 0.1 6.5e-69 231.1 0.0 4.1 4 0 0 4 4 4 2 P-loop containing dynein motor region MT PF12777.7 EFO61633.1 - 4.5e-48 164.0 7.8 7.7e-48 163.3 7.8 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 EFO61633.1 - 1.2e-45 155.3 0.7 3.9e-45 153.6 0.1 2.3 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 EFO61633.1 - 6.7e-45 152.0 0.0 2.3e-42 143.9 0.1 3.2 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 EFO61633.1 - 1.7e-22 79.9 2.6 4e-22 78.7 0.0 3.2 4 0 0 4 4 4 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 EFO61633.1 - 6.2e-20 71.3 1.4 8.3e-19 67.7 1.4 2.9 1 1 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFO61633.1 - 1.3e-10 41.4 0.0 0.011 15.7 0.0 5.7 4 1 0 4 4 4 2 AAA domain (dynein-related subfamily) DHR10 PF18595.1 EFO61633.1 - 0.00026 21.0 5.9 0.00026 21.0 5.9 5.4 5 0 0 5 5 3 1 Designed helical repeat protein 10 domain AAA_16 PF13191.6 EFO61633.1 - 0.0007 20.0 0.0 6.8 7.0 0.0 4.3 5 0 0 5 5 3 2 AAA ATPase domain AAA PF00004.29 EFO61633.1 - 0.00082 19.8 0.2 0.66 10.4 0.0 4.1 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFO61633.1 - 0.0011 19.3 0.1 15 5.9 0.0 5.6 5 0 0 5 5 5 0 AAA domain AAA_18 PF13238.6 EFO61633.1 - 0.009 16.6 0.0 0.97 10.0 0.0 3.4 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EFO61633.1 - 0.01 14.9 0.6 0.49 9.4 0.0 3.4 4 0 0 4 4 4 0 Type II/IV secretion system protein LCIB_C_CA PF18599.1 EFO61633.1 - 0.53 9.5 2.3 4.4 6.5 1.2 2.7 2 0 0 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases kleA_kleC PF17383.2 EFO61633.1 - 6.9 7.1 5.8 2.2 8.6 1.2 2.8 2 0 0 2 2 1 0 Uncharacterized KorC regulated protein A DEAD PF00270.29 EFO61634.1 - 4e-34 117.9 0.0 2.3e-33 115.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO61634.1 - 6.2e-22 78.0 0.0 3e-21 75.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFO61634.1 - 4.5e-11 42.8 0.0 9.7e-11 41.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) MNHE PF01899.16 EFO61634.1 - 0.16 11.7 0.1 0.35 10.6 0.1 1.5 1 0 0 1 1 1 0 Na+/H+ ion antiporter subunit Aa_trans PF01490.18 EFO61635.1 - 6.5e-27 94.3 32.2 9.8e-27 93.7 32.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EFO61635.1 - 0.11 11.5 29.7 0.34 9.9 29.7 2.0 1 1 0 1 1 1 0 Tryptophan/tyrosine permease family DUF2157 PF09925.9 EFO61635.1 - 8.4 6.2 8.4 0.65 9.8 0.2 2.9 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) Ank_2 PF12796.7 EFO61636.1 - 6e-17 62.0 0.9 4.8e-12 46.3 0.1 2.8 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61636.1 - 1e-10 41.9 0.3 8e-07 29.5 0.0 3.8 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO61636.1 - 1.4e-10 41.2 0.1 0.00032 20.9 0.0 3.9 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO61636.1 - 3.2e-07 30.5 0.1 0.058 13.9 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EFO61636.1 - 7.4e-07 29.0 0.0 2.2 9.1 0.0 4.9 5 0 0 5 5 5 2 Ankyrin repeat APG6_N PF17675.1 EFO61636.1 - 0.032 14.8 3.1 0.067 13.7 3.1 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region Mto2_bdg PF12808.7 EFO61636.1 - 0.044 14.1 5.2 0.11 12.9 1.7 2.8 1 1 1 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF4349 PF14257.6 EFO61636.1 - 0.16 11.4 1.7 0.29 10.5 1.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) bZIP_2 PF07716.15 EFO61636.1 - 0.26 11.4 1.8 0.64 10.1 1.8 1.7 1 0 0 1 1 1 0 Basic region leucine zipper YabA PF06156.13 EFO61636.1 - 0.79 10.4 3.2 2.1 9.1 2.8 1.9 1 1 0 1 1 1 0 Initiation control protein YabA Csm1_N PF18504.1 EFO61636.1 - 0.92 9.9 4.2 1 9.8 1.2 2.4 2 0 0 2 2 2 0 Csm1 N-terminal domain Ank_2 PF12796.7 EFO61638.1 - 8.2e-39 132.1 5.2 3.2e-12 46.9 0.1 4.5 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61638.1 - 1.7e-25 88.7 9.5 0.00027 21.2 0.0 7.3 2 1 5 7 7 7 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61638.1 - 2.5e-24 85.3 2.3 2.6e-06 27.9 0.2 5.5 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO61638.1 - 1.1e-22 79.3 2.2 0.0052 17.2 0.0 6.6 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.6 EFO61638.1 - 7.6e-17 59.7 4.3 0.15 12.7 0.1 7.2 6 0 0 6 6 6 4 Ankyrin repeat DUF948 PF06103.11 EFO61639.1 - 0.051 13.8 0.6 0.34 11.2 0.1 2.8 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.10 EFO61639.1 - 0.36 11.0 9.2 0.64 10.2 0.3 4.0 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family AAA_33 PF13671.6 EFO61639.1 - 0.42 10.8 2.6 20 5.3 0.1 3.2 3 0 0 3 3 3 0 AAA domain ETC_C1_NDUFA5 PF04716.14 EFO61639.1 - 0.43 10.4 2.4 13 5.7 0.0 3.6 3 0 0 3 3 3 0 ETC complex I subunit conserved region PMC2NT PF08066.12 EFO61639.1 - 0.53 11.0 7.0 1.5 9.6 0.1 4.4 5 0 0 5 5 5 0 PMC2NT (NUC016) domain Syntaxin-6_N PF09177.11 EFO61639.1 - 1.3 9.6 5.1 21 5.8 0.0 3.9 3 1 0 3 3 3 0 Syntaxin 6, N-terminal DUF327 PF03885.13 EFO61639.1 - 1.3 9.0 7.3 0.097 12.6 0.5 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF327) HsbA PF12296.8 EFO61639.1 - 1.3 9.5 8.0 1.2 9.6 0.5 3.6 4 0 0 4 4 4 0 Hydrophobic surface binding protein A Tht1 PF04163.12 EFO61639.1 - 1.4 7.5 10.9 2 7.1 0.4 2.9 4 0 0 4 4 4 0 Tht1-like nuclear fusion protein Acetyltransf_11 PF13720.6 EFO61639.1 - 2.4 8.7 4.9 1.8 9.1 0.1 3.2 3 0 0 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 HisKA PF00512.25 EFO61639.1 - 3.1 7.9 6.1 1.4 9.0 0.1 3.5 3 1 1 4 4 3 0 His Kinase A (phospho-acceptor) domain Pkinase PF00069.25 EFO61640.1 - 1.7e-90 302.9 0.0 3.5e-49 167.5 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61640.1 - 3.4e-46 157.6 0.0 5.9e-22 78.2 0.0 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase Ank_2 PF12796.7 EFO61640.1 - 6.9e-27 93.9 1.5 1.7e-09 38.1 0.0 6.1 3 2 2 6 6 6 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61640.1 - 6.3e-17 61.4 5.7 0.0013 19.0 0.1 6.4 3 1 3 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO61640.1 - 1e-13 51.0 1.5 0.039 14.4 0.0 6.7 7 0 0 7 7 7 3 Ankyrin repeat Ank_3 PF13606.6 EFO61640.1 - 3.9e-12 45.2 1.7 0.45 11.2 0.0 6.2 6 0 0 6 6 5 4 Ankyrin repeat Ank_4 PF13637.6 EFO61640.1 - 4.9e-11 42.9 0.2 0.0072 16.9 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Kinase-like PF14531.6 EFO61640.1 - 1.6e-09 37.5 0.0 0.0014 18.0 0.0 3.5 3 2 0 3 3 3 2 Kinase-like APH PF01636.23 EFO61640.1 - 4.5e-06 26.8 0.0 0.0027 17.7 0.0 2.7 2 1 0 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFO61640.1 - 6.4e-06 25.2 0.0 9.5e-05 21.3 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 EFO61640.1 - 0.03 13.3 0.2 0.1 11.5 0.1 1.9 2 0 0 2 2 2 0 Haspin like kinase domain Choline_kinase PF01633.20 EFO61640.1 - 0.047 13.3 0.0 2.7 7.5 0.0 3.0 2 1 1 3 3 3 0 Choline/ethanolamine kinase DUF4471 PF14740.6 EFO61642.1 - 1.5e-18 67.1 0.0 3.4e-15 56.1 0.3 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF4471) DUF4470 PF14737.6 EFO61642.1 - 0.00034 20.7 0.1 0.00093 19.3 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) Phage_tail_APC PF16778.5 EFO61643.1 - 0.019 14.8 0.1 0.059 13.2 0.1 1.9 1 0 0 1 1 1 0 Phage tail assembly chaperone protein Pkinase PF00069.25 EFO61644.1 - 8.2e-41 140.1 0.0 2.1e-24 86.3 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61644.1 - 8.6e-17 61.3 0.0 5.9e-09 35.6 0.0 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFO61644.1 - 7.4e-05 22.2 0.0 0.017 14.4 0.0 2.5 2 1 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 EFO61644.1 - 0.047 12.6 0.1 0.047 12.6 0.1 1.7 2 0 0 2 2 2 0 Haspin like kinase domain VSP PF03302.13 EFO61646.1 - 4.9e-59 200.2 201.3 1.8e-41 142.3 79.4 6.1 2 1 2 4 4 4 4 Giardia variant-specific surface protein DIM PF08194.12 EFO61646.1 - 0.021 15.0 0.3 0.021 15.0 0.3 8.6 10 0 0 10 10 10 0 DIM protein DUF3147 PF11345.8 EFO61646.1 - 0.06 13.7 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3147) PARM PF17061.5 EFO61646.1 - 0.22 11.6 2.1 0.45 10.6 2.1 1.4 1 0 0 1 1 1 0 PARM Vpu PF00558.19 EFO61646.1 - 0.44 10.4 1.3 0.73 9.6 1.3 1.3 1 0 0 1 1 1 0 Vpu protein Rep_fac-A_C PF08646.10 EFO61647.1 - 5.3e-10 39.2 0.0 1.5e-08 34.5 0.0 2.4 2 0 0 2 2 2 1 Replication factor-A C terminal domain tRNA_anti-codon PF01336.25 EFO61647.1 - 5.7e-09 35.8 0.1 2.3e-06 27.5 0.0 2.6 2 0 0 2 2 2 2 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 EFO61647.1 - 3.7e-06 26.8 0.0 0.018 14.8 0.0 3.3 2 1 0 2 2 2 2 Cell division control protein 24, OB domain 3 REPA_OB_2 PF16900.5 EFO61647.1 - 0.019 14.9 0.1 0.071 13.0 0.0 1.9 2 0 0 2 2 2 0 Replication protein A OB domain DUF5088 PF17008.5 EFO61647.1 - 0.034 13.9 0.0 0.81 9.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5088) zinc-ribbons_6 PF07191.12 EFO61647.1 - 0.054 13.5 0.6 0.12 12.4 0.6 1.4 1 0 0 1 1 1 0 zinc-ribbons zf-C4H2 PF10146.9 EFO61647.1 - 0.2 12.0 0.5 0.32 11.3 0.5 1.5 1 1 0 1 1 1 0 Zinc finger-containing protein SPRY PF00622.28 EFO61650.1 - 0.001 19.2 0.0 0.0022 18.1 0.0 1.5 1 0 0 1 1 1 1 SPRY domain KIF1B PF12423.8 EFO61650.1 - 0.019 15.4 0.4 0.21 12.1 0.0 2.6 2 0 0 2 2 2 0 Kinesin protein 1B DUF1184 PF06683.11 EFO61651.1 - 0.0033 16.9 0.3 0.0033 16.9 0.3 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF1184) NMT1 PF09084.11 EFO61651.1 - 0.02 14.8 0.0 0.074 13.0 0.0 1.9 2 0 0 2 2 2 0 NMT1/THI5 like TMF_TATA_bd PF12325.8 EFO61652.1 - 0.0025 18.0 4.5 0.0025 18.0 4.5 16.7 5 3 13 20 20 20 5 TATA element modulatory factor 1 TATA binding WD40_alt PF14077.6 EFO61652.1 - 0.23 11.4 5.0 10 6.1 0.1 5.2 3 0 0 3 3 3 0 Alternative WD40 repeat motif BRI3BP PF14965.6 EFO61652.1 - 2.1 7.8 6.2 42 3.6 0.2 4.3 4 0 0 4 4 4 0 Negative regulator of p53/TP53 Na_Ca_ex_C PF16494.5 EFO61652.1 - 5.4 7.5 8.8 14 6.1 0.7 4.6 3 0 0 3 3 3 0 C-terminal extension of sodium/calcium exchanger domain Arf PF00025.21 EFO61653.1 - 2.1e-23 82.6 0.0 2.7e-23 82.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EFO61653.1 - 2e-07 30.5 1.2 0.011 15.0 0.2 2.5 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EFO61653.1 - 5.7e-07 29.8 0.1 2.5e-06 27.7 0.1 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFO61653.1 - 1.3e-06 28.1 0.2 2e-06 27.5 0.2 1.3 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EFO61653.1 - 6.2e-06 26.3 0.2 2.4e-05 24.4 0.2 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFO61653.1 - 4.7e-05 22.9 0.1 5.9e-05 22.6 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 EFO61653.1 - 0.0013 18.8 0.1 0.0015 18.6 0.1 1.2 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 EFO61653.1 - 0.0014 18.3 0.0 0.45 10.3 0.0 2.1 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.27 EFO61653.1 - 0.0021 17.6 0.2 0.012 15.2 0.1 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EFO61653.1 - 0.0026 17.8 0.3 0.13 12.3 0.1 2.2 1 1 1 2 2 2 1 Dynamin family Gtr1_RagA PF04670.12 EFO61653.1 - 0.015 14.7 0.2 0.025 14.0 0.2 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFO61653.1 - 0.026 14.4 0.0 1.8 8.5 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_29 PF13555.6 EFO61653.1 - 0.054 13.2 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 EFO61653.1 - 0.064 12.7 0.0 0.11 11.9 0.0 1.5 2 0 0 2 2 2 0 Bacterial TniB protein ABC_tran PF00005.27 EFO61653.1 - 0.15 12.6 0.1 0.2 12.1 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 EFO61653.1 - 0.17 12.4 0.0 0.22 12.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain TIMELESS_C PF05029.13 EFO61653.1 - 0.17 11.0 0.0 0.2 10.7 0.0 1.0 1 0 0 1 1 1 0 Timeless protein C terminal region IF4E PF01652.18 EFO61654.1 - 1.4e-11 44.4 0.0 1.7e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E PUFD PF16553.5 EFO61654.1 - 0.0034 17.5 0.1 0.0055 16.8 0.1 1.3 1 0 0 1 1 1 1 BCORL-PCGF1-binding domain DUF2347 PF09804.9 EFO61655.1 - 1.1e-06 28.5 0.1 5.4e-06 26.2 0.0 2.1 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2347) DUF3918 PF13056.6 EFO61655.1 - 0.3 10.7 1.9 0.65 9.7 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) His_Phos_2 PF00328.22 EFO61657.1 - 5.4e-45 154.4 0.1 6.3e-45 154.2 0.1 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Ank_2 PF12796.7 EFO61659.1 - 1.4e-35 121.7 4.7 2.3e-09 37.7 0.1 6.8 4 3 2 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61659.1 - 6.5e-14 51.8 6.9 0.38 11.1 0.1 7.9 5 3 3 8 8 8 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61659.1 - 2.1e-11 44.1 0.5 0.84 10.3 0.1 8.1 3 3 7 10 10 10 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61659.1 - 1.1e-08 34.6 10.7 20 6.2 0.0 10.4 11 0 0 11 11 11 2 Ankyrin repeat Ank PF00023.30 EFO61659.1 - 5.7e-07 29.7 6.4 13 6.4 0.0 7.5 7 0 0 7 7 7 3 Ankyrin repeat CENP-F_N PF10481.9 EFO61660.1 - 0.0096 15.6 1.7 0.0096 15.6 1.7 1.8 2 0 0 2 2 2 1 Cenp-F N-terminal domain Antigen_Bd37 PF11641.8 EFO61660.1 - 0.011 15.2 2.1 0.015 14.8 2.1 1.2 1 0 0 1 1 1 0 Glycosylphosphatidylinositol-anchored merozoite surface protein bMG5 PF17972.1 EFO61660.1 - 0.014 15.8 0.4 0.2 12.0 0.0 2.7 2 1 1 3 3 3 0 Bacterial Alpha-2-macroglobulin MG5 domain SMC_ScpB PF04079.16 EFO61660.1 - 0.038 13.6 1.1 0.54 9.9 0.0 2.2 1 1 1 2 2 2 0 Segregation and condensation complex subunit ScpB Nup54 PF13874.6 EFO61660.1 - 0.11 12.6 2.0 0.18 11.9 2.0 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Hrs_helical PF12210.8 EFO61660.1 - 0.18 12.4 2.0 0.35 11.4 1.4 1.7 1 1 1 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate FlaC_arch PF05377.11 EFO61660.1 - 5.3 7.5 8.6 1.6 9.1 1.1 2.4 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Phospholip_B PF04916.13 EFO61661.1 - 2e-82 277.5 0.6 2.7e-82 277.1 0.6 1.0 1 0 0 1 1 1 1 Phospholipase B STT3 PF02516.14 EFO61662.1 - 3.1e-60 204.5 40.9 5.9e-59 200.3 40.9 2.1 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit DUF3377 PF11857.8 EFO61662.1 - 0.005 16.7 1.3 12 6.0 0.0 3.9 4 0 0 4 4 4 2 Domain of unknown function (DUF3377) SSPI PF14098.6 EFO61662.1 - 0.16 12.1 0.0 0.36 11.0 0.0 1.4 1 0 0 1 1 1 0 Small, acid-soluble spore protein I Pox_A14 PF05767.12 EFO61662.1 - 1.1 9.5 6.3 16 5.8 0.2 4.2 3 1 0 3 3 3 0 Poxvirus virion envelope protein A14 VSP PF03302.13 EFO61664.1 - 5.9e-64 216.4 89.8 1.5e-40 139.3 19.5 3.1 1 1 2 3 3 3 3 Giardia variant-specific surface protein VSP PF03302.13 EFO61665.1 - 1e-145 485.6 200.7 2.2e-136 454.8 109.9 4.1 1 1 3 4 4 4 3 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO61665.1 - 0.3 11.2 0.0 0.3 11.2 0.0 2.6 2 1 1 3 3 3 0 Podoplanin zf-RING_2 PF13639.6 EFO61666.1 - 2.8e-10 40.4 36.3 2.3e-07 31.0 14.7 3.4 2 1 0 2 2 2 2 Ring finger domain zf-ANAPC11 PF12861.7 EFO61666.1 - 9.5e-06 25.6 21.9 0.0014 18.6 9.8 2.7 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EFO61666.1 - 1.4e-05 25.2 31.1 0.0033 17.7 7.4 3.2 2 1 1 3 3 3 2 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EFO61666.1 - 0.00018 21.4 30.7 0.0095 15.9 12.5 2.7 2 0 0 2 2 2 2 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFO61666.1 - 0.00026 21.0 20.6 0.00093 19.2 3.1 3.8 2 2 1 3 3 3 2 RING-type zinc-finger Vps39_2 PF10367.9 EFO61666.1 - 0.0026 18.2 0.1 0.0026 18.2 0.1 2.8 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 zf-C3HC4_2 PF13923.6 EFO61666.1 - 0.0044 16.8 13.2 0.0044 16.8 13.2 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.14 EFO61666.1 - 0.0063 16.3 10.8 4.2 7.3 0.7 4.9 5 0 0 5 5 5 2 Rad50 zinc hook motif PHD PF00628.29 EFO61666.1 - 0.0064 16.4 12.7 0.0064 16.4 12.7 2.9 3 0 0 3 3 3 1 PHD-finger Zn_ribbon_17 PF17120.5 EFO61666.1 - 0.008 15.8 11.4 0.008 15.8 11.4 2.7 3 0 0 3 3 3 1 Zinc-ribbon, C4HC2 type zf-C3HC4 PF00097.25 EFO61666.1 - 0.0097 15.8 12.3 0.0097 15.8 12.3 3.0 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFO61666.1 - 0.16 11.7 27.5 0.046 13.5 9.3 4.2 3 1 0 3 3 3 0 RING-like zinc finger Prok-RING_4 PF14447.6 EFO61666.1 - 7.2 6.6 35.4 7.1 6.6 0.2 4.3 3 1 1 4 4 4 0 Prokaryotic RING finger family 4 DUF3800 PF12686.7 EFO61667.1 - 1.1e-05 26.1 0.5 4 8.1 0.5 6.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3800) DUF3584 PF12128.8 EFO61667.1 - 0.00086 17.0 40.6 0.00086 17.0 40.6 7.1 1 1 4 6 6 6 4 Protein of unknown function (DUF3584) NYD-SP28 PF14772.6 EFO61667.1 - 0.0073 16.3 1.4 0.0073 16.3 1.4 19.0 10 5 6 18 18 18 6 Sperm tail PKcGMP_CC PF16808.5 EFO61667.1 - 0.011 15.5 1.5 0.011 15.5 1.5 19.7 22 1 0 22 22 22 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Erf4 PF10256.9 EFO61667.1 - 1.5 9.0 5.8 1.7 8.7 0.2 4.0 3 0 0 3 3 3 0 Golgin subfamily A member 7/ERF4 family Annexin PF00191.20 EFO61668.1 - 0.12 12.5 0.0 0.4 10.8 0.0 1.9 1 0 0 1 1 1 0 Annexin Annexin PF00191.20 EFO61669.1 - 8.4e-06 25.8 0.0 0.52 10.4 0.0 3.4 3 0 0 3 3 3 2 Annexin AAA PF00004.29 EFO61671.1 - 3.1e-44 150.6 0.0 1.1e-35 123.0 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFO61671.1 - 6.5e-11 41.9 0.5 1.6e-10 40.6 0.0 2.1 2 0 0 2 2 2 1 AAA+ lid domain AAA_22 PF13401.6 EFO61671.1 - 5.6e-08 33.2 0.0 4.8e-05 23.7 0.1 3.3 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EFO61671.1 - 0.00011 22.2 0.4 0.0038 17.2 0.1 3.2 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFO61671.1 - 0.00069 19.4 0.2 0.13 12.0 0.0 2.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 EFO61671.1 - 0.0026 17.6 0.1 0.36 10.7 0.0 3.4 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EFO61671.1 - 0.0034 16.8 0.0 0.01 15.3 0.0 1.8 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 EFO61671.1 - 0.0035 16.6 0.1 2.1 7.5 0.1 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_24 PF13479.6 EFO61671.1 - 0.0042 16.8 0.1 0.028 14.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EFO61671.1 - 0.0047 17.1 0.0 0.014 15.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EFO61671.1 - 0.0056 17.1 0.5 0.022 15.1 0.2 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 EFO61671.1 - 0.006 17.1 0.0 0.22 12.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EFO61671.1 - 0.01 15.7 0.1 9.4 6.1 0.0 3.3 3 0 0 3 3 3 0 NACHT domain AAA_25 PF13481.6 EFO61671.1 - 0.016 14.8 0.2 3.8 7.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EFO61671.1 - 0.022 14.7 0.1 1.2 9.1 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 EFO61671.1 - 0.064 13.4 0.0 0.28 11.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFO61671.1 - 0.098 13.1 0.0 0.35 11.3 0.0 2.1 2 0 0 2 2 1 0 RNA helicase AAA_19 PF13245.6 EFO61671.1 - 2.8 8.3 6.0 0.87 9.9 0.1 3.0 4 0 0 4 4 4 0 AAA domain PhoLip_ATPase_C PF16212.5 EFO61672.1 - 3.2e-31 109.0 28.1 3.2e-31 109.0 28.1 2.8 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal E1-E2_ATPase PF00122.20 EFO61672.1 - 4.6e-13 49.1 0.2 4.6e-13 49.1 0.2 2.5 2 1 1 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EFO61672.1 - 1.3e-08 35.3 0.0 0.0017 18.7 0.0 3.3 4 0 0 4 4 4 2 haloacid dehalogenase-like hydrolase PhoLip_ATPase_N PF16209.5 EFO61672.1 - 9.9e-08 31.6 7.7 2.8e-07 30.1 7.7 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFO61672.1 - 7.1e-07 29.2 0.0 1.5e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFO61672.1 - 0.029 14.1 0.0 3.5 7.3 0.0 3.0 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase GUCT PF08152.12 EFO61673.1 - 0.0089 16.3 0.2 0.014 15.7 0.1 1.4 1 1 0 1 1 1 1 GUCT (NUC152) domain LXG PF04740.12 EFO61673.1 - 0.019 14.7 1.7 0.023 14.4 1.7 1.0 1 0 0 1 1 1 0 LXG domain of WXG superfamily Baculo_PEP_C PF04513.12 EFO61673.1 - 0.02 15.0 3.0 0.025 14.6 3.0 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3584 PF12128.8 EFO61673.1 - 0.036 11.6 0.2 0.04 11.5 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) phiKZ_IP PF12699.7 EFO61673.1 - 0.047 12.8 0.4 0.051 12.7 0.4 1.1 1 0 0 1 1 1 0 phiKZ-like phage internal head proteins Exog_C PF18026.1 EFO61673.1 - 0.05 13.7 0.1 0.091 12.8 0.1 1.4 1 0 0 1 1 1 0 Endo/exonuclease (EXOG) C-terminal domain DUF948 PF06103.11 EFO61673.1 - 0.053 13.8 2.0 0.079 13.2 2.0 1.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) BLOC1_2 PF10046.9 EFO61673.1 - 0.063 13.6 1.7 0.92 9.9 0.1 2.0 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cytochrom_B562 PF07361.11 EFO61673.1 - 0.071 13.8 0.6 0.085 13.5 0.6 1.1 1 0 0 1 1 1 0 Cytochrome b562 Exonuc_VII_S PF02609.16 EFO61673.1 - 0.091 12.8 0.2 0.29 11.2 0.1 1.9 2 0 0 2 2 2 0 Exonuclease VII small subunit Thioredoxin PF00085.20 EFO61674.1 - 1.5e-06 28.1 0.0 3.2e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin NTP_transf_2 PF01909.23 EFO61675.1 - 0.00042 20.6 0.0 0.00084 19.6 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EFO61675.1 - 0.0026 17.8 0.1 0.0062 16.6 0.1 1.7 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase PAP_assoc PF03828.19 EFO61675.1 - 0.006 16.8 1.5 0.023 14.9 0.7 2.1 2 0 0 2 2 2 1 Cid1 family poly A polymerase COG5 PF10392.9 EFO61676.1 - 0.41 10.8 4.4 4.1 7.6 0.5 2.8 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Glyco_transf_21 PF13506.6 EFO61677.1 - 1.2e-09 37.9 0.0 2.7e-09 36.7 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EFO61677.1 - 1.2e-05 25.2 0.0 2.3e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EFO61677.1 - 0.0026 17.7 0.0 0.0062 16.4 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 PTPLA PF04387.14 EFO61678.1 - 0.00014 21.6 5.9 0.00023 21.0 5.9 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA GAS PF13851.6 EFO61679.1 - 6.6e-63 211.7 20.9 6.6e-63 211.7 20.9 3.3 1 1 2 3 3 3 2 Growth-arrest specific micro-tubule binding DUF4235 PF14019.6 EFO61679.1 - 0.15 12.2 0.1 0.29 11.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4235) DUF1827 PF08860.10 EFO61679.1 - 0.17 12.1 0.1 0.17 12.1 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1827) DUF4250 PF14056.6 EFO61679.1 - 0.7 9.9 3.5 5.2 7.1 0.1 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4250) Jnk-SapK_ap_N PF09744.9 EFO61681.1 - 0.023 14.9 3.3 0.023 14.9 3.3 2.1 1 1 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF4473 PF14747.6 EFO61681.1 - 0.033 14.7 1.4 0.068 13.7 1.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) Leu_zip PF15294.6 EFO61681.1 - 0.061 12.8 11.2 0.16 11.5 11.2 1.6 1 1 0 1 1 1 0 Leucine zipper DUF5343 PF17278.2 EFO61681.1 - 0.066 13.3 1.1 0.15 12.2 0.4 1.8 1 1 0 2 2 2 0 Family of unknown function (DUF5343) Fungal_TACC PF12709.7 EFO61681.1 - 0.23 11.9 5.1 6.4 7.3 0.3 2.6 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins JIP_LZII PF16471.5 EFO61681.1 - 0.28 11.4 8.3 2.1 8.6 1.1 2.4 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II SOGA PF11365.8 EFO61681.1 - 0.87 10.8 8.9 9.8 7.4 0.5 2.7 1 1 1 2 2 2 0 Protein SOGA Annexin PF00191.20 EFO61682.1 - 2.2e-06 27.6 0.0 0.017 15.2 0.0 3.5 4 1 0 4 4 4 2 Annexin Ank_2 PF12796.7 EFO61683.1 - 2.5e-96 316.4 33.2 3.8e-15 56.2 0.3 9.4 2 2 6 9 9 9 9 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61683.1 - 6.5e-58 192.0 34.5 0.00016 21.9 0.0 16.1 3 3 14 17 17 17 14 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61683.1 - 4.8e-56 186.5 28.0 4.3e-08 33.5 0.1 12.5 8 3 5 13 13 13 13 Ankyrin repeats (many copies) Ank PF00023.30 EFO61683.1 - 1.2e-49 164.6 27.8 0.00034 20.9 0.0 16.5 16 0 0 16 16 16 14 Ankyrin repeat Ank_3 PF13606.6 EFO61683.1 - 3e-47 153.1 26.4 0.084 13.5 0.0 18.5 20 0 0 20 20 20 14 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO61683.1 - 1.4e-12 47.2 7.5 4e-12 45.8 7.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO61683.1 - 6.3e-07 29.2 8.0 1.3e-06 28.1 8.0 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFO61683.1 - 0.00026 21.3 8.5 0.00064 20.0 8.5 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFO61683.1 - 0.0094 15.8 10.6 0.023 14.5 10.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFO61683.1 - 0.011 15.7 7.3 0.024 14.6 7.3 1.6 1 0 0 1 1 1 0 zinc-RING finger domain Ank_2 PF12796.7 EFO61684.1 - 8.3e-16 58.4 0.7 6.3e-11 42.7 0.1 2.7 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFO61684.1 - 2.1e-08 34.2 2.9 0.00057 20.2 0.0 5.0 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 EFO61684.1 - 1.2e-07 31.9 0.6 0.018 15.4 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61684.1 - 1.6e-07 31.1 1.6 0.023 15.2 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EFO61684.1 - 4.1e-07 30.4 0.1 0.022 15.3 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Annexin PF00191.20 EFO61685.1 - 1.5e-17 63.4 1.3 1e-09 38.3 0.4 3.4 3 0 0 3 3 3 3 Annexin YTH PF04146.15 EFO61685.1 - 0.18 11.8 0.1 0.5 10.3 0.0 1.7 2 0 0 2 2 2 0 YT521-B-like domain VSP PF03302.13 EFO61686.1 - 1.3e-72 244.8 180.2 3.8e-43 147.8 30.0 3.8 1 1 2 3 3 3 3 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO61686.1 - 0.14 12.3 105.9 0.44 10.7 2.4 9.1 1 1 8 9 9 9 0 Furin-like repeat, cysteine-rich Podoplanin PF05808.11 EFO61686.1 - 6.1 6.9 5.9 11 6.1 1.3 2.9 2 1 1 3 3 3 0 Podoplanin UTP25 PF06862.12 EFO61687.1 - 1.5e-42 146.0 0.0 7e-25 87.7 0.0 2.4 1 1 1 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 RRM_1 PF00076.22 EFO61688.1 - 4.2e-09 36.1 0.4 4.5e-07 29.6 0.0 3.9 4 1 1 5 5 5 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 EFO61689.1 - 2.5e-59 200.8 0.0 3.5e-59 200.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61689.1 - 8.2e-33 113.8 0.0 1.4e-32 113.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO61689.1 - 8.5e-30 103.2 0.1 1.1e-10 41.9 0.0 3.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EFO61689.1 - 1.3e-18 66.5 1.7 0.0089 16.4 0.0 6.5 5 1 1 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EFO61689.1 - 2.2e-18 66.1 3.8 0.0061 16.8 0.0 6.0 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61689.1 - 9.9e-17 61.1 1.6 3.1e-06 27.6 0.0 5.8 3 2 3 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61689.1 - 4.7e-16 57.3 2.3 0.039 14.5 0.0 6.7 5 1 1 6 6 6 3 Ankyrin repeat Kinase-like PF14531.6 EFO61689.1 - 0.0077 15.6 0.0 0.015 14.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFO61689.1 - 0.0087 15.0 0.0 0.018 14.0 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFO61689.1 - 0.0088 16.0 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Lipoprotein_15 PF03640.15 EFO61689.1 - 0.014 14.9 0.1 0.03 13.9 0.1 1.5 1 0 0 1 1 1 0 Secreted repeat of unknown function Pkinase_fungal PF17667.1 EFO61689.1 - 0.048 12.4 0.0 0.083 11.6 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Ank_2 PF12796.7 EFO61690.1 - 3e-37 127.1 7.4 4.4e-09 36.8 0.4 5.9 2 2 5 7 7 7 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61690.1 - 8.8e-21 73.7 7.7 0.0023 18.2 0.0 8.6 4 3 5 9 9 9 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61690.1 - 4.1e-16 57.4 6.8 0.5 11.1 0.1 9.7 10 0 0 10 10 9 3 Ankyrin repeat Ank PF00023.30 EFO61690.1 - 2.2e-15 56.3 8.2 0.18 12.3 0.0 9.3 8 1 1 9 9 9 3 Ankyrin repeat Ank_4 PF13637.6 EFO61690.1 - 4.1e-14 52.8 3.8 0.019 15.6 0.3 7.4 6 1 1 7 7 7 4 Ankyrin repeats (many copies) YabA PF06156.13 EFO61690.1 - 0.00016 22.2 20.1 0.39 11.4 0.0 5.3 4 1 1 5 5 5 1 Initiation control protein YabA Fez1 PF06818.15 EFO61690.1 - 0.012 16.1 29.9 0.61 10.5 3.9 4.7 5 0 0 5 5 4 0 Fez1 TMF_DNA_bd PF12329.8 EFO61690.1 - 0.022 14.7 0.3 0.022 14.7 0.3 6.3 5 1 1 6 6 6 0 TATA element modulatory factor 1 DNA binding Syntaxin-18_N PF10496.9 EFO61690.1 - 0.051 13.8 1.8 0.11 12.7 0.4 2.4 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus DUF668 PF05003.12 EFO61690.1 - 0.28 11.7 1.9 13 6.3 0.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF668) APG6_N PF17675.1 EFO61690.1 - 0.5 10.9 39.5 0.59 10.7 4.6 4.7 3 1 1 4 4 4 0 Apg6 coiled-coil region SpoOE-like PF09388.10 EFO61690.1 - 0.53 10.2 4.7 20 5.2 0.6 3.3 2 0 0 2 2 2 0 Spo0E like sporulation regulatory protein bZIP_2 PF07716.15 EFO61690.1 - 0.59 10.3 17.7 6.8 6.9 2.6 4.7 4 1 0 4 4 4 0 Basic region leucine zipper Seryl_tRNA_N PF02403.22 EFO61690.1 - 2.4 8.4 31.0 0.072 13.3 4.9 4.8 4 1 1 5 5 5 0 Seryl-tRNA synthetase N-terminal domain ATG16 PF08614.11 EFO61690.1 - 2.6 8.2 37.7 1.1 9.5 2.4 4.9 4 2 0 4 4 4 0 Autophagy protein 16 (ATG16) GAS PF13851.6 EFO61690.1 - 2.6 7.3 36.2 0.073 12.4 5.4 4.6 4 0 0 4 4 4 0 Growth-arrest specific micro-tubule binding PKcGMP_CC PF16808.5 EFO61690.1 - 4.8 7.1 15.4 3.4 7.6 0.0 4.4 4 0 0 4 4 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ADIP PF11559.8 EFO61690.1 - 5 7.2 35.7 3.6 7.7 1.4 5.4 4 1 0 4 4 4 0 Afadin- and alpha -actinin-Binding HrpB2 PF09487.10 EFO61690.1 - 5.8 7.4 7.8 0.47 10.9 0.8 2.8 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB2) KASH_CCD PF14662.6 EFO61690.1 - 9.9 5.9 34.1 3.7 7.4 2.2 4.6 4 0 0 4 4 4 0 Coiled-coil region of CCDC155 or KASH tRNA-synt_2 PF00152.20 EFO61691.1 - 1.6e-70 237.7 0.0 2e-70 237.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFO61691.1 - 1.7e-10 40.7 0.0 3.4e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EFO61691.1 - 1.2e-06 28.2 0.1 0.0022 17.6 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.25 EFO61691.1 - 0.13 12.2 0.0 0.35 10.8 0.0 1.8 1 1 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) Tubulin PF00091.25 EFO61692.1 - 1.8e-32 113.1 0.0 2.2e-32 112.9 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.9 EFO61692.1 - 3e-06 27.5 0.0 4.5e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain VSP PF03302.13 EFO61693.1 - 5.6e-23 81.4 38.7 1.1e-18 67.3 9.1 3.0 1 1 2 3 3 3 3 Giardia variant-specific surface protein DUF543 PF04418.12 EFO61693.1 - 0.041 13.9 0.7 0.067 13.2 0.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF543) DUF4690 PF15756.5 EFO61693.1 - 0.066 13.8 0.0 0.088 13.4 0.0 1.2 1 0 0 1 1 1 0 Small Novel Rich in Cartilage SKG6 PF08693.10 EFO61693.1 - 0.1 12.0 4.8 0.23 10.9 4.8 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Furin-like_2 PF15913.5 EFO61693.1 - 0.15 12.2 12.9 0.29 11.3 4.8 2.3 1 1 1 2 2 2 0 Furin-like repeat, cysteine-rich cEGF PF12662.7 EFO61693.1 - 0.17 11.9 6.4 0.19 11.7 0.5 2.8 2 0 0 2 2 2 0 Complement Clr-like EGF-like Podoplanin PF05808.11 EFO61693.1 - 0.19 11.8 2.4 0.25 11.4 2.4 1.3 1 1 0 1 1 1 0 Podoplanin VSP PF03302.13 EFO61694.1 - 1.2e-73 248.2 170.5 1e-69 235.3 89.6 4.9 1 1 2 4 4 4 3 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO61694.1 - 0.00038 20.6 16.3 0.00038 20.6 16.3 12.3 2 2 7 11 11 11 4 Furin-like repeat, cysteine-rich DUF4215 PF13948.6 EFO61694.1 - 0.0012 19.3 3.7 0.0012 19.3 3.7 12.6 12 2 0 13 13 13 2 Domain of unknown function (DUF4215) CobU PF02283.16 EFO61698.1 - 0.00043 19.9 0.2 0.009 15.6 0.0 2.7 2 0 0 2 2 2 1 Cobinamide kinase / cobinamide phosphate guanyltransferase FAM76 PF16046.5 EFO61698.1 - 7 5.9 12.2 30 3.8 12.2 2.1 1 0 0 1 1 1 0 FAM76 protein VSP PF03302.13 EFO61699.1 - 4.6e-27 94.9 57.5 3.4e-25 88.8 57.5 3.7 1 1 0 1 1 1 1 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO61699.1 - 4.4 7.5 25.2 0.4 10.9 11.5 2.9 1 1 2 3 3 3 0 Furin-like repeat, cysteine-rich Pkinase PF00069.25 EFO61701.1 - 5.4e-41 140.7 0.3 2.3e-23 82.9 0.0 2.8 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61701.1 - 4.6e-12 45.8 0.3 3.5e-10 39.6 0.0 2.8 3 0 0 3 3 3 1 Protein tyrosine kinase APH PF01636.23 EFO61701.1 - 6.8e-05 22.9 0.0 0.0072 16.3 0.0 3.5 2 1 0 3 3 3 1 Phosphotransferase enzyme family Lebercilin PF15619.6 EFO61701.1 - 0.004 16.8 4.7 0.004 16.8 4.7 3.2 3 0 0 3 3 3 1 Ciliary protein causing Leber congenital amaurosis disease BRE1 PF08647.11 EFO61701.1 - 8.4 6.6 18.1 50 4.1 6.7 4.1 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase Ank_2 PF12796.7 EFO61702.1 - 2e-47 159.7 17.6 6.6e-13 49.1 0.1 6.4 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61702.1 - 8.2e-27 92.9 13.3 0.00036 20.8 0.0 7.3 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO61702.1 - 1.8e-26 91.4 13.4 0.0053 17.2 0.0 10.1 9 2 2 11 11 11 7 Ankyrin repeat Ank_4 PF13637.6 EFO61702.1 - 6.8e-23 80.7 9.3 4.4e-08 33.5 0.0 7.6 7 2 0 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61702.1 - 2.1e-21 73.7 9.2 0.01 16.3 0.0 9.4 10 0 0 10 10 10 5 Ankyrin repeat Lant_dehydr_C PF14028.6 EFO61703.1 - 0.00013 21.7 2.5 0.0002 21.0 2.5 1.4 1 0 0 1 1 1 1 Lantibiotic biosynthesis dehydratase C-term Filament PF00038.21 EFO61703.1 - 0.0024 17.5 13.8 0.0024 17.5 13.8 2.9 1 1 2 3 3 3 2 Intermediate filament protein DUF3375 PF11855.8 EFO61703.1 - 0.0044 16.0 2.6 0.0044 16.0 2.6 2.4 2 1 0 2 2 2 2 Protein of unknown function (DUF3375) DUF4600 PF15372.6 EFO61703.1 - 0.008 16.6 21.9 0.04 14.4 12.8 2.8 2 1 0 2 2 2 2 Domain of unknown function (DUF4600) DUF842 PF05811.13 EFO61703.1 - 0.14 11.8 0.3 0.14 11.8 0.3 3.2 1 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) SF-assemblin PF06705.11 EFO61703.1 - 0.19 11.0 29.6 1.4 8.2 15.6 2.0 1 1 1 2 2 2 0 SF-assemblin/beta giardin LMBR1 PF04791.16 EFO61703.1 - 0.76 8.6 10.8 1.2 8.0 10.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein TMPIT PF07851.13 EFO61703.1 - 8.4 5.5 20.7 4.6 6.4 10.2 2.4 1 1 2 3 3 3 0 TMPIT-like protein WD40 PF00400.32 EFO61704.1 - 3.6e-12 46.6 8.9 4.3e-05 24.2 0.4 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat PQQ_3 PF13570.6 EFO61704.1 - 0.13 12.8 0.1 1.2e+02 3.4 0.0 3.6 3 0 0 3 3 3 0 PQQ-like domain Tubulin PF00091.25 EFO61705.1 - 1.5e-66 224.4 0.0 2.2e-66 223.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFO61705.1 - 1.6e-51 173.7 0.1 2.8e-51 172.9 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EFO61705.1 - 0.00016 21.5 0.0 0.00029 20.6 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Sec2p PF06428.11 EFO61705.1 - 0.18 11.8 0.0 0.36 10.8 0.0 1.4 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p VSP PF03302.13 EFO61706.1 - 7.9e-26 90.8 48.2 2.3e-19 69.5 8.9 3.0 1 1 2 3 3 3 3 Giardia variant-specific surface protein BmKX PF09132.10 EFO61706.1 - 7.7e-16 57.8 17.3 7.7e-16 57.8 17.3 3.5 3 0 0 3 3 3 1 BmKX Furin-like_2 PF15913.5 EFO61706.1 - 0.019 15.1 20.2 0.4 10.8 2.3 3.1 1 1 2 3 3 3 0 Furin-like repeat, cysteine-rich Podoplanin PF05808.11 EFO61706.1 - 3.3 7.8 4.7 1.7 8.7 1.5 1.9 2 0 0 2 2 2 0 Podoplanin Proteasome PF00227.26 EFO61707.1 - 6.1e-29 100.9 0.0 7.7e-29 100.5 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit DUF1681 PF07933.14 EFO61708.1 - 4.6e-39 133.5 0.0 5.2e-39 133.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) DUF3618 PF12277.8 EFO61709.1 - 0.038 14.3 1.7 0.058 13.7 1.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3618) CENP-F_leu_zip PF10473.9 EFO61709.1 - 0.04 14.0 0.1 0.058 13.4 0.1 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1840 PF08895.11 EFO61709.1 - 0.092 13.1 0.1 0.14 12.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) Val_tRNA-synt_C PF10458.9 EFO61709.1 - 0.25 11.6 1.0 0.42 10.9 1.0 1.3 1 0 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm PHP_C PF13263.6 EFO61710.1 - 0.00017 21.3 0.0 0.00041 20.0 0.0 1.6 1 0 0 1 1 1 1 PHP-associated PHP PF02811.19 EFO61710.1 - 0.00096 19.5 1.6 0.0045 17.3 1.6 2.1 1 1 0 1 1 1 1 PHP domain EIF_2_alpha PF07541.12 EFO61712.1 - 2.8e-19 69.3 0.0 5e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EFO61712.1 - 2.6e-09 37.3 0.0 5.2e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 S1 RNA binding domain Band_7 PF01145.25 EFO61712.1 - 0.054 13.5 0.1 2.8 7.9 0.0 2.3 2 0 0 2 2 2 0 SPFH domain / Band 7 family NHL PF01436.21 EFO61716.1 - 3.4e-11 42.6 10.0 2.5e-05 24.1 0.1 5.6 7 0 0 7 7 7 2 NHL repeat SGL PF08450.12 EFO61716.1 - 0.0024 17.5 0.0 0.027 14.0 0.0 2.2 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region TBCA PF02970.16 EFO61717.1 - 0.0087 16.4 11.6 0.0087 16.4 11.6 2.4 2 1 1 3 3 3 1 Tubulin binding cofactor A DUF4795 PF16043.5 EFO61717.1 - 0.25 10.9 20.2 0.2 11.2 2.4 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4795) DUF4771 PF15995.5 EFO61717.1 - 0.32 11.3 8.3 0.09 13.0 1.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4771) CT_C_D PF02682.16 EFO61717.1 - 2.3 7.9 5.3 2.2 8.0 3.5 2.0 2 1 1 3 3 3 0 Carboxyltransferase domain, subdomain C and D DUF812 PF05667.11 EFO61717.1 - 3.2 6.5 25.7 13 4.6 25.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF812) Baculo_PEP_C PF04513.12 EFO61717.1 - 7.3 6.6 15.1 4.1 7.4 4.9 2.7 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus UPF0242 PF06785.11 EFO61717.1 - 7.8 6.6 32.0 0.3 11.1 6.4 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus ENTH PF01417.20 EFO61718.1 - 6.6e-30 103.7 0.1 1.3e-29 102.8 0.1 1.5 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 EFO61718.1 - 1.4e-05 24.2 0.0 1.4e-05 24.2 0.0 1.7 2 0 0 2 2 2 1 ANTH domain TFIIA PF03153.13 EFO61718.1 - 3 7.8 37.9 5 7.0 37.9 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sec7 PF01369.20 EFO61719.1 - 1.1e-33 116.5 4.7 1.6e-27 96.3 0.7 3.2 3 0 0 3 3 3 2 Sec7 domain CBFD_NFYB_HMF PF00808.23 EFO61721.1 - 6.8e-16 58.3 0.0 8e-16 58.1 0.0 1.1 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 EFO61721.1 - 0.0061 16.7 0.0 0.0063 16.6 0.0 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EFO61721.1 - 0.022 15.1 0.0 0.026 14.9 0.0 1.1 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 EFO61721.1 - 0.054 13.5 0.1 0.095 12.7 0.0 1.5 1 1 0 1 1 1 0 Bromodomain associated DUF4391 PF14335.6 EFO61721.1 - 0.055 13.2 0.0 0.068 12.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) 4HB_MCP_1 PF12729.7 EFO61722.1 - 0.18 11.4 3.4 0.15 11.6 0.8 2.1 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction Folate_carrier PF01770.18 EFO61724.1 - 1.1e-92 311.0 27.8 1.3e-92 310.7 27.8 1.0 1 0 0 1 1 1 1 Reduced folate carrier GWT1 PF06423.12 EFO61724.1 - 6.7 6.8 15.7 0.19 11.9 2.5 3.2 2 2 0 2 2 2 0 GWT1 Ank_2 PF12796.7 EFO61725.1 - 9.8e-07 29.3 0.7 7.6e-05 23.2 0.0 3.0 2 1 1 3 3 2 1 Ankyrin repeats (3 copies) HAP1_N PF04849.13 EFO61725.1 - 0.0015 17.8 22.7 0.0031 16.8 6.1 2.7 2 1 0 3 3 3 2 HAP1 N-terminal conserved region Ank_3 PF13606.6 EFO61725.1 - 0.0045 17.4 0.1 0.48 11.2 0.0 3.6 3 0 0 3 3 2 1 Ankyrin repeat Ank PF00023.30 EFO61725.1 - 0.0059 17.0 0.0 0.022 15.2 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeat GAS PF13851.6 EFO61725.1 - 0.03 13.7 12.7 0.62 9.4 2.1 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding HALZ PF02183.18 EFO61725.1 - 0.056 13.7 0.6 0.056 13.7 0.6 3.7 4 0 0 4 4 3 0 Homeobox associated leucine zipper Ank_5 PF13857.6 EFO61725.1 - 0.056 13.8 0.0 0.36 11.2 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeats (many copies) bZIP_1 PF00170.21 EFO61725.1 - 0.07 13.2 18.7 0.047 13.8 1.7 4.7 4 1 1 5 5 5 0 bZIP transcription factor Vps23_core PF09454.10 EFO61725.1 - 0.095 12.7 0.5 0.52 10.3 0.1 2.4 2 0 0 2 2 2 0 Vps23 core domain Filament PF00038.21 EFO61725.1 - 0.099 12.2 15.6 0.4 10.2 1.9 2.8 2 1 0 2 2 2 0 Intermediate filament protein GrpE PF01025.19 EFO61725.1 - 0.21 11.2 6.9 0.2 11.3 1.4 3.0 3 0 0 3 3 3 0 GrpE KASH_CCD PF14662.6 EFO61725.1 - 0.25 11.2 18.7 10 5.9 18.2 2.7 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DivIC PF04977.15 EFO61725.1 - 0.41 10.4 12.4 1.2 9.0 5.1 3.0 2 1 0 2 2 2 0 Septum formation initiator ZapB PF06005.12 EFO61725.1 - 0.42 11.1 21.4 0.14 12.6 1.7 4.0 4 1 0 4 4 4 0 Cell division protein ZapB Shugoshin_N PF07558.11 EFO61725.1 - 0.76 9.7 10.0 2.8 7.9 0.2 3.4 3 2 1 4 4 3 0 Shugoshin N-terminal coiled-coil region AKNA PF12443.8 EFO61725.1 - 0.76 10.5 4.4 0.66 10.7 0.6 2.7 2 0 0 2 2 2 0 AT-hook-containing transcription factor TSC22 PF01166.18 EFO61725.1 - 1.4 9.2 21.4 2.5 8.5 1.2 5.2 3 2 2 5 5 5 0 TSC-22/dip/bun family UPF0449 PF15136.6 EFO61725.1 - 2 8.9 12.0 0.3 11.6 0.4 3.1 2 1 1 3 3 3 0 Uncharacterised protein family UPF0449 Ax_dynein_light PF10211.9 EFO61725.1 - 2.4 8.1 12.8 0.58 10.1 0.4 2.6 3 0 0 3 3 2 0 Axonemal dynein light chain CENP-H PF05837.12 EFO61725.1 - 3.7 8.0 14.3 1.1 9.7 0.7 2.9 3 0 0 3 3 2 0 Centromere protein H (CENP-H) YabA PF06156.13 EFO61725.1 - 4.4 8.0 16.4 1.4e+03 -0.1 0.0 3.3 2 1 0 2 2 2 0 Initiation control protein YabA JIP_LZII PF16471.5 EFO61725.1 - 9.7 6.4 10.0 18 5.6 0.9 3.3 2 2 0 2 2 2 0 JNK-interacting protein leucine zipper II zf-C2H2_4 PF13894.6 EFO61729.1 - 0.0086 16.8 1.3 0.034 15.0 1.3 2.1 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 EFO61729.1 - 0.023 15.1 2.5 0.087 13.3 2.5 2.0 1 0 0 1 1 1 0 Zinc finger, C2H2 type TFIIF_beta_N PF17683.1 EFO61729.1 - 0.066 13.9 6.0 2.6 8.8 2.7 2.9 2 1 0 2 2 2 0 TFIIF, beta subunit N-terminus CsgA PF17334.2 EFO61730.1 - 0.018 15.8 0.4 1.3 9.8 0.0 3.4 3 0 0 3 3 3 0 Minor curli fiber component A Myb_DNA-binding PF00249.31 EFO61732.1 - 3.5e-05 23.9 0.0 3.5e-05 23.9 0.0 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFO61732.1 - 0.00013 21.8 0.5 0.00026 20.8 0.5 1.5 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 EFO61732.1 - 0.0022 18.2 0.3 0.0046 17.2 0.3 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Ras PF00071.22 EFO61733.1 - 1.5e-38 131.9 0.0 1.8e-38 131.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFO61733.1 - 2.5e-24 85.8 0.0 3.3e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFO61733.1 - 1.4e-06 27.9 0.0 1.8e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 EFO61733.1 - 0.0003 20.5 0.0 0.0074 16.0 0.0 2.2 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 EFO61733.1 - 0.00095 19.2 0.0 0.0013 18.8 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFO61733.1 - 0.0018 17.9 0.0 1.2 8.6 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B DUF447 PF04289.12 EFO61733.1 - 0.055 13.3 0.0 0.078 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF447) RsgA_GTPase PF03193.16 EFO61733.1 - 0.18 11.7 0.1 13 5.7 0.0 2.3 2 1 0 2 2 2 0 RsgA GTPase DUF5077 PF16871.5 EFO61733.1 - 0.19 11.6 0.0 0.47 10.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5077) HECT PF00632.25 EFO61735.1 - 6.1e-26 91.6 0.0 1.8e-25 90.1 0.0 1.9 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) EGF_2 PF07974.13 EFO61736.1 - 6.2e-24 84.1 177.1 1.1e-05 25.7 8.6 14.3 14 1 0 14 14 14 10 EGF-like domain EGF PF00008.27 EFO61736.1 - 7.8e-11 42.1 155.7 9.9e-05 22.6 8.6 15.2 13 2 2 15 15 15 9 EGF-like domain EGF_Tenascin PF18720.1 EFO61736.1 - 0.00029 20.8 8.7 0.00029 20.8 8.7 13.4 15 3 2 17 17 17 3 Tenascin EGF domain hEGF PF12661.7 EFO61736.1 - 0.00041 20.9 26.8 0.0015 19.1 11.0 17.5 17 1 0 17 17 17 8 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 EFO61736.1 - 0.0073 16.6 3.2 0.0073 16.6 3.2 12.2 10 2 2 12 12 12 3 Pvs28 EGF domain Laminin_EGF PF00053.24 EFO61736.1 - 0.012 15.7 9.7 0.012 15.7 9.7 11.2 5 3 4 9 9 9 0 Laminin EGF domain EB PF01683.18 EFO61736.1 - 0.025 14.9 9.4 0.025 14.9 9.4 12.7 7 3 4 12 12 12 0 EB module Helicase_C PF00271.31 EFO61737.1 - 8.4e-12 45.4 0.0 2.3e-11 44.0 0.0 1.7 1 1 0 1 1 1 1 Helicase conserved C-terminal domain Peptidase_C1 PF00112.23 EFO61738.1 - 1.1e-30 107.4 3.9 4.8e-19 69.3 1.0 3.3 3 0 0 3 3 3 3 Papain family cysteine protease APG6_N PF17675.1 EFO61740.1 - 0.00021 21.8 1.6 0.00028 21.4 1.6 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region Spc24 PF08286.11 EFO61740.1 - 0.00027 21.2 1.3 0.0005 20.3 1.3 1.4 1 0 0 1 1 1 1 Spc24 subunit of Ndc80 Anp1 PF03452.14 EFO61740.1 - 0.0026 17.2 1.3 0.0033 16.9 1.3 1.1 1 0 0 1 1 1 1 Anp1 COG2 PF06148.11 EFO61740.1 - 0.016 15.3 2.2 0.029 14.4 1.6 1.6 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 RAP1 PF07218.11 EFO61740.1 - 0.033 12.5 0.1 0.039 12.2 0.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) OmpH PF03938.14 EFO61740.1 - 0.045 14.1 0.3 0.059 13.7 0.3 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) CorA PF01544.18 EFO61740.1 - 0.052 12.9 1.3 0.066 12.5 0.5 1.5 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Exonuc_VII_S PF02609.16 EFO61740.1 - 0.053 13.6 0.7 0.093 12.8 0.7 1.4 1 0 0 1 1 1 0 Exonuclease VII small subunit DUF4140 PF13600.6 EFO61740.1 - 0.07 13.6 0.1 0.07 13.6 0.1 2.0 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Phycobilisome PF00502.19 EFO61740.1 - 0.072 13.0 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Phycobilisome protein V_ATPase_I PF01496.19 EFO61740.1 - 0.082 10.8 1.1 0.095 10.6 1.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SecA_DEAD PF07517.14 EFO61740.1 - 0.083 12.2 0.6 0.35 10.1 0.6 1.8 2 0 0 2 2 2 0 SecA DEAD-like domain DUF2205 PF10224.9 EFO61740.1 - 0.11 12.5 4.3 0.13 12.3 0.6 2.4 1 1 1 2 2 2 0 Short coiled-coil protein YabA PF06156.13 EFO61740.1 - 0.16 12.6 1.4 0.33 11.6 1.4 1.5 1 0 0 1 1 1 0 Initiation control protein YabA FapA PF03961.13 EFO61740.1 - 0.17 10.5 1.3 0.2 10.3 1.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A COG5 PF10392.9 EFO61740.1 - 0.22 11.7 6.3 0.2 11.8 0.8 2.1 1 1 1 2 2 2 0 Golgi transport complex subunit 5 MRFAP1 PF15155.6 EFO61740.1 - 0.71 10.4 4.2 13 6.4 2.3 2.8 1 1 1 2 2 2 0 MORF4 family-associated protein1 CCDC-167 PF15188.6 EFO61740.1 - 1.8 9.0 7.3 0.77 10.1 0.6 2.4 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 DivIC PF04977.15 EFO61740.1 - 3.7 7.4 5.5 2.5 8.0 2.3 2.0 1 1 1 2 2 2 0 Septum formation initiator AAA PF00004.29 EFO61741.1 - 5.7e-38 130.3 0.1 1.8e-36 125.4 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFO61741.1 - 6.6e-11 41.8 0.0 1.8e-10 40.5 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 EFO61741.1 - 4.3e-09 36.2 1.2 9.4e-09 35.2 0.2 2.1 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 EFO61741.1 - 1.8e-05 24.5 0.0 3.8e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFO61741.1 - 6.3e-05 23.3 0.1 0.015 15.6 0.0 2.8 2 1 1 3 3 2 1 AAA domain AAA_16 PF13191.6 EFO61741.1 - 0.00014 22.3 0.5 0.0084 16.5 0.2 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EFO61741.1 - 0.00067 19.7 0.2 0.0093 16.0 0.1 2.8 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EFO61741.1 - 0.0011 18.7 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_17 PF13207.6 EFO61741.1 - 0.0012 19.3 0.0 0.0035 17.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 EFO61741.1 - 0.0045 16.3 0.1 0.018 14.3 0.1 1.9 1 1 1 2 2 2 1 TIP49 P-loop domain Mg_chelatase PF01078.21 EFO61741.1 - 0.0089 15.4 0.1 0.025 13.9 0.1 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 EFO61741.1 - 0.012 15.7 0.0 0.03 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) ATPase PF06745.13 EFO61741.1 - 0.014 14.8 0.5 0.88 8.9 0.0 2.7 2 1 1 3 3 3 0 KaiC AAA_18 PF13238.6 EFO61741.1 - 0.021 15.4 0.5 0.11 13.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EFO61741.1 - 0.023 14.2 0.1 0.055 12.9 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_33 PF13671.6 EFO61741.1 - 0.032 14.4 0.0 0.081 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFO61741.1 - 0.043 13.9 0.0 0.15 12.1 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_28 PF13521.6 EFO61741.1 - 0.059 13.6 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 EFO61741.1 - 0.065 12.3 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_24 PF13479.6 EFO61741.1 - 0.07 12.8 0.0 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFO61741.1 - 0.092 13.1 0.0 0.27 11.6 0.0 1.8 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 EFO61741.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EFO61741.1 - 0.14 12.1 0.1 0.49 10.3 0.1 1.9 1 0 0 1 1 1 0 NACHT domain RabGAP-TBC PF00566.18 EFO61742.1 - 5.5e-52 176.5 0.4 8.1e-52 176.0 0.4 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Cytokin_check_N PF10407.9 EFO61744.1 - 0.00061 19.7 0.6 0.0011 18.8 0.6 1.4 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus Ank_2 PF12796.7 EFO61745.1 - 9.9e-09 35.7 0.9 0.00055 20.5 0.2 2.9 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO61745.1 - 1.7e-07 31.0 1.5 0.23 12.1 0.3 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EFO61745.1 - 0.00045 20.5 0.1 1.3 9.6 0.2 3.3 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EFO61745.1 - 0.00097 19.4 0.2 0.79 10.1 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61745.1 - 0.056 14.0 0.2 0.16 12.6 0.2 1.8 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Peptidase_C1 PF00112.23 EFO61746.1 - 3.3e-22 79.7 0.1 3.2e-21 76.4 0.1 2.3 1 1 0 1 1 1 1 Papain family cysteine protease TMEM154 PF15102.6 EFO61746.1 - 0.11 12.4 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 TMEM154 protein family 5_nucleotid_C PF02872.18 EFO61747.1 - 0.021 15.0 0.0 0.039 14.1 0.0 1.4 1 0 0 1 1 1 0 5'-nucleotidase, C-terminal domain TIM PF00121.18 EFO61748.1 - 3.8e-89 298.3 0.3 4.3e-89 298.1 0.3 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase DeoRC PF00455.22 EFO61748.1 - 0.086 12.8 0.5 0.16 11.9 0.5 1.4 1 0 0 1 1 1 0 DeoR C terminal sensor domain Pkinase PF00069.25 EFO61750.1 - 4.9e-66 222.8 0.0 6e-66 222.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61750.1 - 1.7e-32 112.7 0.0 2.1e-32 112.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFO61750.1 - 7.1e-05 21.9 0.1 9.7e-05 21.5 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EFO61750.1 - 0.0093 15.3 0.0 0.028 13.7 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFO61750.1 - 0.016 14.0 0.0 0.022 13.5 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Methyltr_RsmB-F PF01189.17 EFO61751.1 - 2.7e-40 138.2 0.0 1.1e-38 132.9 0.0 2.2 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EFO61751.1 - 0.086 12.9 0.0 0.26 11.4 0.0 1.8 1 1 0 1 1 1 0 FtsJ-like methyltransferase LRR_8 PF13855.6 EFO61752.1 - 0.00038 20.2 16.4 2.6 7.9 0.1 6.4 6 1 0 6 6 6 3 Leucine rich repeat GILT PF03227.16 EFO61752.1 - 0.00067 19.9 0.0 0.0016 18.7 0.0 1.7 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) LRR_4 PF12799.7 EFO61752.1 - 0.0018 18.6 19.1 1.8 9.1 0.1 5.8 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) PRIMA1 PF16101.5 EFO61752.1 - 0.0059 16.6 0.4 0.011 15.8 0.4 1.3 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 DUF4998 PF16389.5 EFO61752.1 - 0.017 14.8 0.3 0.031 13.8 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function IPK PF03770.16 EFO61753.1 - 2.5e-14 53.6 0.0 4e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Inositol polyphosphate kinase Hexapep PF00132.24 EFO61754.1 - 1.6e-05 24.4 9.2 0.071 12.9 0.5 4.0 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 EFO61754.1 - 5.8e-05 22.2 2.5 0.003 16.6 0.1 2.9 3 0 0 3 3 3 2 L-fucokinase DUF4954 PF16314.5 EFO61754.1 - 0.0049 15.1 0.7 0.011 13.9 0.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 EFO61754.1 - 0.03 14.1 9.5 0.72 9.7 0.7 3.0 1 1 1 2 2 2 0 Hexapeptide repeat of succinyl-transferase SNARE PF05739.19 EFO61755.1 - 5.6e-05 23.1 0.1 0.00013 21.9 0.1 1.7 1 0 0 1 1 1 1 SNARE domain DUF4661 PF15576.6 EFO61755.1 - 0.039 13.9 0.4 0.066 13.1 0.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4661) CAP_N PF01213.19 EFO61756.1 - 0.28 10.6 1.6 0.38 10.2 1.6 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal VSP PF03302.13 EFO61757.1 - 6.7e-151 502.6 199.5 1.9e-141 471.5 108.7 4.1 1 1 3 4 4 4 3 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO61757.1 - 0.032 14.3 0.0 0.032 14.3 0.0 2.7 2 1 1 3 3 3 0 Podoplanin SH2_2 PF14633.6 EFO61761.1 - 1.3e-08 34.5 0.0 2.9e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 SH2 domain YtpI PF14007.6 EFO61762.1 - 0.071 13.3 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 YtpI-like protein EGF PF00008.27 EFO61763.1 - 0.001 19.3 3.3 0.001 19.3 3.3 33.8 32 5 0 32 32 32 17 EGF-like domain EGF_2 PF07974.13 EFO61763.1 - 0.0046 17.3 7.1 0.0046 17.3 7.1 36.5 36 4 1 37 37 37 16 EGF-like domain WD40 PF00400.32 EFO61764.1 - 6.6e-09 36.3 8.7 1 10.4 0.1 6.7 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO61764.1 - 3e-06 27.5 0.0 1.1 9.6 0.0 4.6 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 EFO61764.1 - 0.26 11.2 1.8 3.9 7.4 0.2 3.1 2 1 0 3 3 3 0 Transcription factor IIIC subunit delta N-term PD40 PF07676.12 EFO61764.1 - 0.28 11.2 3.9 3.8 7.6 0.2 4.0 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat DNTTIP1_dimer PF18192.1 EFO61765.1 - 0.037 14.4 1.2 7 7.1 0.0 3.8 4 0 0 4 4 4 0 DNTTIP1 dimerisation domain Peptidase_M90 PF06167.12 EFO61765.1 - 0.11 12.1 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Glucose-regulated metallo-peptidase M90 DUF3930 PF13067.6 EFO61771.1 - 0.05 13.9 0.1 0.13 12.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3930) ANAPC4_WD40 PF12894.7 EFO61772.1 - 1.2e-07 31.9 0.2 0.098 13.0 0.0 4.9 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFO61772.1 - 4.8e-07 30.4 13.2 0.61 11.0 0.2 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat PQQ_3 PF13570.6 EFO61772.1 - 0.00043 20.7 0.7 0.3 11.6 0.0 4.6 4 1 1 5 5 5 1 PQQ-like domain PQQ PF01011.21 EFO61772.1 - 0.00046 20.0 0.9 0.0013 18.5 0.2 2.2 2 0 0 2 2 2 1 PQQ enzyme repeat PQQ_2 PF13360.6 EFO61772.1 - 0.0055 16.3 0.0 0.094 12.3 0.0 2.5 3 1 0 3 3 3 1 PQQ-like domain BORCS6 PF10157.9 EFO61773.1 - 0.027 14.7 1.7 0.076 13.2 0.2 2.5 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 6 Ribosomal_S4Pg PF11993.8 EFO61773.1 - 0.18 11.8 2.9 0.17 11.9 0.6 2.1 2 0 0 2 2 2 0 Ribosomal S4P (gammaproteobacterial) Synthase_beta PF11421.8 EFO61773.1 - 1.3 9.8 4.7 6.3 7.6 4.7 2.2 1 0 0 1 1 1 0 ATP synthase F1 beta subunit AAA PF00004.29 EFO61774.1 - 5.1e-36 124.0 0.0 8.5e-36 123.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFO61774.1 - 1.2e-09 37.9 0.0 3.3e-09 36.4 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EFO61774.1 - 4.4e-05 23.7 0.0 7.2e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFO61774.1 - 0.002 18.4 0.4 0.17 12.1 0.1 2.8 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 EFO61774.1 - 0.0025 18.2 0.2 0.22 11.9 0.1 2.8 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EFO61774.1 - 0.0051 16.8 0.0 0.017 15.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFO61774.1 - 0.039 13.7 0.0 0.085 12.6 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Zot PF05707.12 EFO61774.1 - 0.1 12.2 0.1 4.4 6.9 0.1 2.4 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_33 PF13671.6 EFO61774.1 - 0.11 12.7 0.0 0.2 11.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain DUF424 PF04242.13 EFO61774.1 - 0.14 12.5 0.0 1.6 9.1 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF424) Mg_chelatase PF01078.21 EFO61774.1 - 0.15 11.4 0.0 0.33 10.3 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EFO61774.1 - 0.15 12.6 0.0 1.2 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EFO61774.1 - 0.18 11.5 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase tRNA-synt_1c PF00749.21 EFO61775.1 - 4.7e-98 328.0 0.0 5.9e-98 327.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EFO61775.1 - 2.8e-24 85.9 0.0 4.3e-24 85.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain Fungal_lectin PF07938.12 EFO61776.1 - 0.12 11.7 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Fungal fucose-specific lectin SF-assemblin PF06705.11 EFO61777.1 - 4.8e-15 55.6 11.2 6.1e-15 55.2 11.2 1.1 1 0 0 1 1 1 1 SF-assemblin/beta giardin Apolipoprotein PF01442.18 EFO61777.1 - 0.012 15.5 6.1 0.063 13.2 5.8 2.1 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain DUF713 PF05218.14 EFO61777.1 - 0.024 14.4 4.5 1.6 8.4 1.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF713) ApoLp-III PF07464.11 EFO61777.1 - 0.033 14.3 0.7 10 6.2 0.0 3.3 2 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) DUF4600 PF15372.6 EFO61777.1 - 0.033 14.6 4.0 0.19 12.2 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) RecG_N PF17190.4 EFO61777.1 - 0.95 10.2 4.4 2.1 9.1 0.7 3.0 3 1 1 4 4 4 0 RecG N-terminal helical domain zf-C4H2 PF10146.9 EFO61777.1 - 1.3 9.2 9.6 2.2 8.5 1.5 2.2 1 1 1 2 2 2 0 Zinc finger-containing protein DUF883 PF05957.13 EFO61777.1 - 4.7 7.9 10.1 1.2 9.8 1.3 3.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) TBCC PF07986.12 EFO61778.1 - 7.7e-31 106.3 0.5 1.1e-30 105.8 0.5 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 EFO61778.1 - 0.023 15.1 0.2 0.039 14.4 0.2 1.4 1 0 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain IclR PF01614.18 EFO61778.1 - 0.039 13.8 0.4 2.8 7.8 0.1 2.2 2 0 0 2 2 2 0 Bacterial transcriptional regulator CAP_C PF08603.11 EFO61778.1 - 0.21 11.2 0.2 0.33 10.6 0.2 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) C terminal UNC80 PF15778.5 EFO61779.1 - 0.078 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Cation channel complex component UNC80 VSP PF03302.13 EFO61780.1 - 1.4e-43 149.3 183.9 9.2e-26 90.6 68.6 5.9 1 1 2 3 3 3 3 Giardia variant-specific surface protein dNK PF01712.19 EFO61781.1 - 1.2e-08 35.0 0.0 1.8e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Deoxynucleoside kinase CLP1_P PF16575.5 EFO61781.1 - 3.9e-05 23.5 0.0 5.4e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_18 PF13238.6 EFO61781.1 - 0.014 15.9 0.0 0.041 14.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain KTI12 PF08433.10 EFO61781.1 - 0.058 12.8 0.0 0.098 12.1 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_16 PF13191.6 EFO61781.1 - 0.081 13.3 0.0 0.12 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain GTP_EFTU PF00009.27 EFO61781.1 - 0.12 11.9 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Cytidylate_kin PF02224.18 EFO61781.1 - 0.14 11.8 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase AAA_14 PF13173.6 EFO61781.1 - 0.16 12.0 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EFO61781.1 - 0.21 11.6 0.0 0.36 10.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_PrkA PF08298.11 EFO61781.1 - 0.24 10.3 0.0 0.3 9.9 0.0 1.1 1 0 0 1 1 1 0 PrkA AAA domain AlbA_2 PF04326.14 EFO61782.1 - 4.9e-14 52.7 0.0 8.2e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 Putative DNA-binding domain Pyocin_S PF06958.12 EFO61784.1 - 0.49 10.9 6.5 0.49 10.9 3.9 2.4 2 0 0 2 2 2 0 S-type Pyocin rve PF00665.26 EFO61785.1 - 0.0022 18.2 0.0 0.0051 17.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Pox_A32 PF04665.12 EFO61789.1 - 1.9e-07 30.8 1.1 1.9e-05 24.3 0.2 2.2 1 1 1 2 2 2 1 Poxvirus A32 protein Seryl_tRNA_N PF02403.22 EFO61789.1 - 0.00069 19.8 0.2 0.0017 18.6 0.2 1.7 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain SRP54 PF00448.22 EFO61789.1 - 0.00075 19.2 0.1 0.0063 16.2 0.1 2.1 1 1 1 2 2 2 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 EFO61789.1 - 0.0012 19.3 0.2 0.0027 18.1 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 EFO61789.1 - 0.0013 18.7 2.4 0.0029 17.5 2.4 1.6 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EFO61789.1 - 0.0015 18.8 0.2 0.0088 16.3 0.2 2.3 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFO61789.1 - 0.0016 18.4 0.0 0.0044 17.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EFO61789.1 - 0.0025 17.8 0.2 0.0038 17.3 0.2 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EFO61789.1 - 0.0027 17.0 0.0 0.0066 15.7 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 EFO61789.1 - 0.0038 16.3 0.7 0.011 14.8 0.2 2.0 1 1 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 EFO61789.1 - 0.0073 16.7 0.0 0.012 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EFO61789.1 - 0.0082 15.3 0.0 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain ABC_tran PF00005.27 EFO61789.1 - 0.0089 16.6 0.0 0.014 15.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 EFO61789.1 - 0.013 16.1 0.0 0.032 14.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.20 EFO61789.1 - 0.023 13.9 0.3 0.3 10.2 0.1 2.0 2 0 0 2 2 2 0 G-protein alpha subunit Viral_helicase1 PF01443.18 EFO61789.1 - 0.025 14.3 0.0 0.07 12.9 0.0 1.8 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_15 PF13175.6 EFO61789.1 - 0.029 14.1 0.1 0.038 13.7 0.1 1.3 1 1 0 1 1 1 0 AAA ATPase domain Rop-like PF05082.13 EFO61789.1 - 0.052 13.4 3.6 2.5 8.0 0.4 3.1 2 1 1 3 3 3 0 Rop-like AAA_29 PF13555.6 EFO61789.1 - 0.056 13.2 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 EFO61789.1 - 0.071 12.8 0.0 0.29 10.8 0.0 1.8 1 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EFO61789.1 - 0.077 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region CbiA PF01656.23 EFO61789.1 - 0.077 13.1 0.0 0.15 12.1 0.0 1.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_28 PF13521.6 EFO61789.1 - 0.08 13.2 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EFO61789.1 - 0.3 10.6 4.3 0.96 9.0 0.5 2.2 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 EFO61789.1 - 7.7 7.0 10.7 0.78 10.2 1.3 2.3 1 1 0 2 2 2 0 AAA domain Pox_C7_F8A PF03287.14 EFO61790.1 - 0.053 13.5 0.2 0.14 12.1 0.2 1.7 1 0 0 1 1 1 0 Poxvirus C7/F8A protein dNK PF01712.19 EFO61792.1 - 1.6e-07 31.4 0.0 2.7e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.6 EFO61792.1 - 0.00029 21.4 0.0 0.00046 20.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFO61792.1 - 0.0023 18.2 0.0 0.0037 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EFO61792.1 - 0.0052 16.1 0.0 0.0093 15.3 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin KTI12 PF08433.10 EFO61792.1 - 0.0056 16.2 0.0 0.019 14.4 0.0 1.7 2 0 0 2 2 2 1 Chromatin associated protein KTI12 NTPase_1 PF03266.15 EFO61792.1 - 0.0061 16.5 0.0 0.014 15.3 0.0 1.6 1 0 0 1 1 1 1 NTPase AAA_16 PF13191.6 EFO61792.1 - 0.008 16.6 0.0 0.014 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain TsaE PF02367.17 EFO61792.1 - 0.0085 16.1 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 EFO61792.1 - 0.01 15.4 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EFO61792.1 - 0.01 14.8 0.0 0.018 14.0 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MobB PF03205.14 EFO61792.1 - 0.013 15.4 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.6 EFO61792.1 - 0.014 15.2 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EFO61792.1 - 0.023 13.8 0.0 0.039 13.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 EFO61792.1 - 0.027 15.0 0.0 0.047 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 EFO61792.1 - 0.049 12.9 0.0 0.068 12.4 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain ATP_bind_1 PF03029.17 EFO61792.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_28 PF13521.6 EFO61792.1 - 0.13 12.5 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EFO61792.1 - 0.13 12.1 0.0 0.37 10.7 0.0 1.8 1 0 0 1 1 1 0 NACHT domain DUF4795 PF16043.5 EFO61796.1 - 0.02 14.5 0.3 0.028 14.0 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) Phage-scaffold PF09306.10 EFO61796.1 - 0.041 13.2 4.1 0.061 12.7 4.1 1.2 1 0 0 1 1 1 0 Bacteriophage, scaffolding protein DUF4112 PF13430.6 EFO61796.1 - 0.074 13.3 0.0 0.18 12.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4112) Mob_Pre PF01076.19 EFO61796.1 - 0.77 9.5 5.4 0.91 9.3 2.9 2.0 2 0 0 2 2 2 0 Plasmid recombination enzyme Phage_Mu_Gam PF07352.12 EFO61796.1 - 1.5 8.7 6.7 3.5 7.5 6.7 1.6 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein Spc7 PF08317.11 EFO61801.1 - 0.001 18.1 0.4 0.0013 17.7 0.4 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein CdvA PF18822.1 EFO61801.1 - 0.001 18.9 1.9 0.0025 17.7 1.9 1.6 1 1 0 1 1 1 1 CdvA-like coiled-coil domain YPEB PF14620.6 EFO61801.1 - 0.0013 18.2 0.2 0.0015 18.0 0.2 1.1 1 0 0 1 1 1 1 YpeB sporulation Baculo_PEP_C PF04513.12 EFO61801.1 - 0.0031 17.6 6.4 0.0047 17.0 6.4 1.2 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.18 EFO61801.1 - 0.0043 17.0 1.8 0.0062 16.4 1.8 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Nup88 PF10168.9 EFO61801.1 - 0.014 13.3 0.1 0.016 13.1 0.1 1.2 1 0 0 1 1 1 0 Nuclear pore component Matrilin_ccoil PF10393.9 EFO61801.1 - 0.015 15.2 0.4 0.056 13.3 0.1 2.1 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin ApoLp-III PF07464.11 EFO61801.1 - 0.016 15.3 2.5 0.024 14.7 2.5 1.2 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) CREPT PF16566.5 EFO61801.1 - 0.025 14.7 1.2 0.13 12.4 0.9 1.9 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Dynamitin PF04912.14 EFO61801.1 - 0.026 13.9 2.1 0.035 13.4 2.1 1.1 1 0 0 1 1 1 0 Dynamitin CCCAP PF15964.5 EFO61801.1 - 0.032 12.5 1.6 0.037 12.3 1.6 1.1 1 0 0 1 1 1 0 Centrosomal colon cancer autoantigen protein family IFT57 PF10498.9 EFO61801.1 - 0.033 13.2 2.2 0.04 12.9 2.2 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 SKA2 PF16740.5 EFO61801.1 - 0.039 13.8 0.8 0.057 13.2 0.8 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Sec34 PF04136.15 EFO61801.1 - 0.042 13.7 1.6 0.064 13.1 1.6 1.2 1 0 0 1 1 1 0 Sec34-like family RPN6_C_helix PF18503.1 EFO61801.1 - 0.048 13.4 0.3 0.048 13.4 0.3 1.9 3 0 0 3 3 1 0 26S proteasome subunit RPN6 C-terminal helix domain DUF1664 PF07889.12 EFO61801.1 - 0.067 13.2 1.6 0.1 12.6 1.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 EFO61801.1 - 0.071 13.4 5.9 0.19 12.0 5.9 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) BLOC1_2 PF10046.9 EFO61801.1 - 0.091 13.1 3.2 3.6 8.0 0.2 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YojJ PF10372.9 EFO61801.1 - 0.11 12.5 0.2 0.56 10.3 0.1 2.0 1 1 1 2 2 2 0 Bacterial membrane-spanning protein N-terminus NPV_P10 PF05531.12 EFO61801.1 - 0.13 12.7 4.4 4.2 7.9 0.1 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein COG2 PF06148.11 EFO61801.1 - 0.17 11.9 2.7 0.7 10.0 2.7 1.8 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 FlgN PF05130.12 EFO61801.1 - 0.25 11.9 3.9 0.57 10.7 3.9 1.5 1 1 0 1 1 1 0 FlgN protein HAUS-augmin3 PF14932.6 EFO61801.1 - 0.32 10.5 2.8 0.5 9.9 2.8 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Syntaxin-6_N PF09177.11 EFO61801.1 - 0.92 10.1 4.0 4.1 8.0 4.0 1.9 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Pox_A32 PF04665.12 EFO61802.1 - 0.0039 16.7 0.0 0.39 10.1 0.0 2.1 2 0 0 2 2 2 2 Poxvirus A32 protein Fer4_12 PF13353.6 EFO61802.1 - 0.048 13.9 0.0 0.079 13.2 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S single cluster domain HTH_50 PF18024.1 EFO61802.1 - 0.089 12.4 0.0 0.35 10.5 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain AAA_22 PF13401.6 EFO61802.1 - 0.13 12.5 0.0 0.27 11.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain PhaP_Bmeg PF09602.10 EFO61804.1 - 0.0081 16.1 0.1 0.011 15.7 0.1 1.1 1 0 0 1 1 1 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DNA_pol_B_2 PF03175.13 EFO61805.1 - 3.5e-25 88.8 0.1 7e-24 84.5 0.0 2.7 2 1 0 2 2 2 1 DNA polymerase type B, organellar and viral YodL PF14191.6 EFO61805.1 - 0.11 13.3 0.0 0.32 11.9 0.0 1.7 1 0 0 1 1 1 0 YodL-like DUF4485 PF14846.6 EFO61806.1 - 2e-14 53.4 0.0 3.3e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4485) Helicase_C_2 PF13307.6 EFO61807.1 - 7.4e-39 133.6 0.0 1.8e-38 132.4 0.0 1.6 1 1 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 EFO61807.1 - 2.5e-17 63.1 0.0 4.4e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 EFO61807.1 - 0.0018 18.3 0.0 0.021 14.8 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SelR PF01641.18 EFO61808.1 - 3e-47 159.7 0.2 3.8e-47 159.3 0.2 1.1 1 0 0 1 1 1 1 SelR domain Ada_Zn_binding PF02805.16 EFO61808.1 - 0.054 13.5 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 Metal binding domain of Ada Prim_Zn_Ribbon PF08273.12 EFO61808.1 - 0.073 13.4 4.0 1.6 9.0 0.3 2.4 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase Lar_restr_allev PF14354.6 EFO61808.1 - 0.21 12.0 2.9 2.5 8.6 2.9 2.2 1 1 0 1 1 1 0 Restriction alleviation protein Lar GFA PF04828.14 EFO61808.1 - 0.21 11.9 2.7 11 6.5 0.2 2.2 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zf-B_box PF00643.24 EFO61808.1 - 0.49 10.6 5.5 9.9 6.4 0.3 2.5 2 0 0 2 2 2 0 B-box zinc finger zf-RRN7 PF11781.8 EFO61808.1 - 2.3 8.0 8.7 0.26 11.0 0.9 2.5 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Glyco_tran_28_C PF04101.16 EFO61809.1 - 6.3e-11 42.5 0.0 7.3e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Histone PF00125.24 EFO61810.1 - 1.7e-24 86.7 0.6 2.1e-24 86.3 0.6 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFO61810.1 - 1.5e-05 25.2 1.1 9.9e-05 22.5 0.1 2.5 3 0 0 3 3 3 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EFO61810.1 - 0.0027 18.1 0.1 0.0045 17.4 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A TAF PF02969.17 EFO61810.1 - 0.0065 16.6 0.2 0.012 15.7 0.2 1.5 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-T_C PF15511.6 EFO61810.1 - 0.034 14.3 0.0 0.044 13.9 0.0 1.4 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold DAGK_prokar PF01219.19 EFO61810.1 - 0.16 11.8 0.4 0.3 10.9 0.4 1.4 1 1 0 1 1 1 0 Prokaryotic diacylglycerol kinase Ank_2 PF12796.7 EFO61811.1 - 3.5e-24 85.2 1.6 8.6e-12 45.5 0.1 4.2 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61811.1 - 1.7e-15 56.9 0.3 0.014 15.7 0.1 4.7 3 1 0 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61811.1 - 2.4e-12 47.1 1.9 1.3e-08 35.1 0.0 4.0 3 1 0 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO61811.1 - 3.4e-12 46.2 1.0 0.0029 18.0 0.1 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 EFO61811.1 - 1.6e-10 40.3 0.6 0.22 12.2 0.0 5.5 5 0 0 5 5 5 4 Ankyrin repeat CCDC24 PF15669.5 EFO61812.1 - 0.021 14.7 7.4 0.49 10.2 0.3 3.3 3 2 1 4 4 4 0 Coiled-coil domain-containing protein 24 family YliH PF10799.8 EFO61813.1 - 0.043 13.8 0.1 0.17 11.8 0.1 2.1 1 0 0 1 1 1 0 Biofilm formation protein (YliH/bssR) ZapB PF06005.12 EFO61813.1 - 0.11 12.9 2.8 0.62 10.6 2.8 2.3 1 0 0 1 1 1 0 Cell division protein ZapB DUF4407 PF14362.6 EFO61813.1 - 0.15 11.4 2.9 0.44 9.9 2.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-MYND PF01753.18 EFO61813.1 - 0.38 10.9 2.3 0.89 9.7 2.3 1.6 1 0 0 1 1 1 0 MYND finger Prefoldin PF02996.17 EFO61813.1 - 1.8 8.5 6.5 2 8.3 2.4 2.9 3 0 0 3 3 3 0 Prefoldin subunit Ribosomal_L5_C PF00673.21 EFO61814.1 - 9.6e-19 67.4 0.0 1.4e-18 66.8 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EFO61814.1 - 6e-18 64.9 0.0 9.9e-18 64.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 UCH_1 PF13423.6 EFO61815.1 - 0.15 11.6 0.9 5.5 6.5 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase Rubredoxin_2 PF18073.1 EFO61815.1 - 0.82 9.4 2.7 15 5.4 0.5 2.4 2 0 0 2 2 2 0 Rubredoxin metal binding domain zf-RING_2 PF13639.6 EFO61815.1 - 4.7 7.6 6.2 2.3 8.6 0.3 2.9 3 0 0 3 3 3 0 Ring finger domain Rad60-SLD PF11976.8 EFO61817.1 - 0.08 12.8 0.0 0.1 12.5 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like NIF PF03031.18 EFO61818.1 - 6.3e-44 149.5 0.0 8.6e-44 149.0 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 EFO61818.1 - 0.0026 18.2 0.1 0.012 16.0 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Reprolysin_4 PF13583.6 EFO61819.1 - 0.016 14.9 0.0 0.067 12.8 0.0 2.1 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DMAP_binding PF06464.11 EFO61823.1 - 0.008 17.0 6.5 0.065 14.1 6.5 2.1 1 1 0 1 1 1 1 DMAP1-binding Domain Sec7 PF01369.20 EFO61824.1 - 0.11 12.1 0.0 0.53 9.9 0.0 2.1 2 0 0 2 2 2 0 Sec7 domain CTP_transf_like PF01467.26 EFO61826.1 - 7.7e-17 61.8 0.0 2.3e-16 60.3 0.0 1.7 1 1 0 1 1 1 1 Cytidylyltransferase-like Nrap PF03813.14 EFO61826.1 - 0.099 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Nrap protein domain 1 Stealth_CR2 PF11380.8 EFO61827.1 - 3.2e-28 98.1 0.1 7.1e-28 96.9 0.0 1.6 2 0 0 2 2 2 1 Stealth protein CR2, conserved region 2 Stealth_CR1 PF17101.5 EFO61827.1 - 4.7e-06 26.2 0.0 1.2e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 KNOX1 PF03790.13 EFO61829.1 - 0.0047 16.6 0.0 0.063 13.0 0.0 2.4 2 0 0 2 2 2 1 KNOX1 domain VSP PF03302.13 EFO61831.1 - 7.4e-37 127.1 69.9 2.6e-25 89.1 34.0 3.2 1 1 2 3 3 3 2 Giardia variant-specific surface protein cEGF PF12662.7 EFO61831.1 - 0.0024 17.8 1.5 0.0024 17.8 1.5 4.6 5 0 0 5 5 5 1 Complement Clr-like EGF-like zf-C2H2_4 PF13894.6 EFO61832.1 - 1 10.4 6.8 4.5 8.4 0.3 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Glyco_hydro_31 PF01055.26 EFO61833.1 - 0.004 16.4 0.0 0.0059 15.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NUDIX PF00293.28 EFO61834.1 - 1.9e-13 50.6 0.0 2.8e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Sec8_exocyst PF04048.14 EFO61835.1 - 0.11 12.4 6.0 2.2 8.2 0.1 3.3 3 0 0 3 3 3 0 Sec8 exocyst complex component specific domain DUF4231 PF14015.6 EFO61836.1 - 0.0094 16.4 2.5 0.0094 16.4 2.5 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4231) Phage_holin_8 PF16931.5 EFO61836.1 - 0.61 10.1 8.0 0.94 9.5 8.0 1.3 1 0 0 1 1 1 0 Putative phage holin Phosphorylase PF00343.20 EFO61837.1 - 5.4e-276 917.5 0.0 6.3e-276 917.3 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase SPOB_a PF14689.6 EFO61837.1 - 0.017 14.8 0.5 2.5 7.9 0.4 2.9 2 0 0 2 2 2 0 Sensor_kinase_SpoOB-type, alpha-helical domain JHY PF15261.6 EFO61839.1 - 5.4e-15 56.3 6.4 6.8e-15 55.9 6.4 1.1 1 0 0 1 1 1 1 Jhy protein DUF2205 PF10224.9 EFO61839.1 - 0.27 11.3 5.4 0.26 11.3 2.5 2.2 2 1 1 3 3 3 0 Short coiled-coil protein UvrB PF12344.8 EFO61839.1 - 4.3 7.3 7.4 10 6.1 1.6 2.5 2 0 0 2 2 2 0 Ultra-violet resistance protein B zf-B_box PF00643.24 EFO61840.1 - 2.6e-11 43.5 20.8 2.9e-06 27.3 6.3 2.2 2 0 0 2 2 2 2 B-box zinc finger DUF745 PF05335.13 EFO61840.1 - 0.029 14.1 3.6 0.051 13.3 3.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DLP_helical PF18709.1 EFO61840.1 - 0.035 13.3 1.9 0.063 12.5 1.9 1.4 1 0 0 1 1 1 0 Dynamin-like helical domain Prefoldin PF02996.17 EFO61840.1 - 0.044 13.7 0.3 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 Prefoldin subunit Syntaxin-6_N PF09177.11 EFO61840.1 - 0.079 13.5 5.4 0.27 11.8 5.2 2.0 1 1 1 2 2 2 0 Syntaxin 6, N-terminal GrpE PF01025.19 EFO61840.1 - 0.1 12.3 2.3 0.21 11.2 2.3 1.5 1 0 0 1 1 1 0 GrpE Laminin_II PF06009.12 EFO61840.1 - 4.7 7.2 6.6 25 4.9 6.7 2.1 1 1 0 1 1 1 0 Laminin Domain II DUF4795 PF16043.5 EFO61840.1 - 5.7 6.5 7.9 23 4.5 7.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) IBR PF01485.21 EFO61840.1 - 7.5 6.9 16.6 1.6 9.0 4.5 2.4 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Peptidase_M20 PF01546.28 EFO61841.1 - 0.1 12.2 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 DEAD PF00270.29 EFO61842.1 - 1.3e-31 109.7 0.1 2.6e-31 108.7 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO61842.1 - 1.4e-19 70.5 0.1 7.2e-19 68.2 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFO61842.1 - 3.1e-07 30.6 0.0 6e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EFO61842.1 - 0.11 11.1 0.1 0.22 10.2 0.0 1.4 1 1 0 1 1 1 0 SNF2 family N-terminal domain Spc24 PF08286.11 EFO61843.1 - 0.0048 17.1 2.3 0.012 15.8 2.3 1.7 1 1 0 1 1 1 1 Spc24 subunit of Ndc80 KxDL PF10241.9 EFO61843.1 - 0.019 15.2 0.8 0.064 13.5 0.8 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein TBCA PF02970.16 EFO61843.1 - 0.019 15.3 0.6 0.03 14.6 0.6 1.4 1 0 0 1 1 1 0 Tubulin binding cofactor A PhaP_Bmeg PF09602.10 EFO61843.1 - 0.024 14.6 0.7 0.04 13.8 0.3 1.6 2 0 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF5082 PF16888.5 EFO61843.1 - 0.031 14.6 1.2 0.057 13.7 1.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) EF_TS PF00889.19 EFO61843.1 - 0.061 12.9 0.3 0.089 12.4 0.3 1.2 1 0 0 1 1 1 0 Elongation factor TS TetR_C_27 PF17935.1 EFO61843.1 - 0.11 12.6 0.1 0.21 11.7 0.0 1.6 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Glutaredoxin2_C PF04399.13 EFO61843.1 - 0.11 12.3 0.7 0.18 11.6 0.1 1.6 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain Spc7 PF08317.11 EFO61843.1 - 0.13 11.1 3.6 0.16 10.9 3.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF948 PF06103.11 EFO61843.1 - 0.18 12.1 1.5 0.48 10.7 0.3 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) THOC7 PF05615.13 EFO61843.1 - 0.21 11.8 5.6 0.45 10.8 5.6 1.5 1 0 0 1 1 1 0 Tho complex subunit 7 HR1 PF02185.16 EFO61843.1 - 0.4 10.8 7.9 0.083 13.0 3.4 2.4 2 1 1 3 3 3 0 Hr1 repeat SlyX PF04102.12 EFO61843.1 - 2.1 9.0 7.3 0.46 11.1 2.5 2.3 3 0 0 3 3 3 0 SlyX Ank_2 PF12796.7 EFO61844.1 - 5.2e-141 459.6 30.5 1.2e-15 57.8 0.1 9.4 1 1 11 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61844.1 - 4.4e-67 221.6 7.0 2e-05 25.1 0.1 13.6 8 3 6 14 14 14 12 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO61844.1 - 4.4e-62 205.3 20.3 1.2e-05 25.5 0.0 15.3 2 2 13 16 16 16 14 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61844.1 - 7.4e-56 179.6 6.6 0.006 17.0 0.1 17.6 17 1 1 18 18 16 11 Ankyrin repeat Ank PF00023.30 EFO61844.1 - 5.9e-53 175.1 19.3 0.014 15.8 0.0 17.4 18 0 0 18 18 16 12 Ankyrin repeat Pkinase PF00069.25 EFO61844.1 - 2.7e-41 141.7 0.0 2.8e-40 138.3 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61844.1 - 2.1e-25 89.5 0.0 4e-25 88.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Fib_alpha PF08702.10 EFO61844.1 - 0.00015 22.0 0.7 0.0098 16.1 0.1 2.7 1 1 1 2 2 2 1 Fibrinogen alpha/beta chain family APH PF01636.23 EFO61844.1 - 0.00074 19.5 0.0 0.0015 18.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family HMMR_N PF15905.5 EFO61844.1 - 0.00086 18.9 4.3 0.007 15.9 4.0 2.2 1 1 1 2 2 2 2 Hyaluronan mediated motility receptor N-terminal DUF4201 PF13870.6 EFO61844.1 - 0.00095 18.9 2.5 0.0021 17.8 2.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) CENP-F_leu_zip PF10473.9 EFO61844.1 - 0.0022 18.0 8.0 0.074 13.1 1.7 3.1 2 1 1 3 3 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 EFO61844.1 - 0.0027 17.1 1.7 0.0076 15.6 1.5 1.9 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding CEP63 PF17045.5 EFO61844.1 - 0.003 17.5 0.6 0.099 12.5 0.2 2.7 1 1 2 3 3 3 1 Centrosomal protein of 63 kDa DUF4200 PF13863.6 EFO61844.1 - 0.0031 17.9 1.6 0.031 14.7 0.4 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) ATG16 PF08614.11 EFO61844.1 - 0.0041 17.4 8.2 0.026 14.7 8.1 2.3 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) HOOK PF05622.12 EFO61844.1 - 0.0057 14.9 4.4 0.011 14.0 4.4 1.4 1 0 0 1 1 1 1 HOOK protein ADIP PF11559.8 EFO61844.1 - 0.008 16.3 5.3 1.6 8.8 1.0 2.8 1 1 2 3 3 3 2 Afadin- and alpha -actinin-Binding AAA_13 PF13166.6 EFO61844.1 - 0.008 14.9 5.1 0.013 14.2 5.1 1.2 1 0 0 1 1 1 1 AAA domain KASH_CCD PF14662.6 EFO61844.1 - 0.0085 15.9 2.7 0.015 15.1 2.7 1.4 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH Spc7 PF08317.11 EFO61844.1 - 0.0096 14.8 6.9 0.02 13.8 4.3 2.1 1 1 1 2 2 2 1 Spc7 kinetochore protein PKcGMP_CC PF16808.5 EFO61844.1 - 0.013 15.3 0.1 0.17 11.8 0.1 2.8 2 1 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF641 PF04859.12 EFO61844.1 - 0.015 15.6 5.8 1.8 8.9 0.6 3.9 1 1 3 4 4 4 0 Plant protein of unknown function (DUF641) DUF3450 PF11932.8 EFO61844.1 - 0.016 14.6 3.7 8.6 5.6 1.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) Fez1 PF06818.15 EFO61844.1 - 0.016 15.6 8.0 0.093 13.2 2.2 3.1 2 1 2 4 4 3 0 Fez1 UPF0242 PF06785.11 EFO61844.1 - 0.022 14.9 0.5 0.054 13.6 0.3 1.7 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF16 PF01519.16 EFO61844.1 - 0.03 14.8 1.4 0.5 10.9 0.2 2.6 1 1 1 2 2 2 0 Protein of unknown function DUF16 MAD PF05557.13 EFO61844.1 - 0.031 12.7 3.2 0.048 12.0 3.2 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein TMF_DNA_bd PF12329.8 EFO61844.1 - 0.039 14.0 12.0 0.35 10.9 4.2 4.3 3 1 2 5 5 4 0 TATA element modulatory factor 1 DNA binding DUF4407 PF14362.6 EFO61844.1 - 0.04 13.3 7.5 0.076 12.4 7.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Atg14 PF10186.9 EFO61844.1 - 0.04 13.0 6.7 0.53 9.3 5.6 2.3 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Tektin PF03148.14 EFO61844.1 - 0.048 12.4 3.3 1.8 7.2 0.2 2.2 2 0 0 2 2 2 0 Tektin family TolA_bind_tri PF16331.5 EFO61844.1 - 0.055 13.5 0.0 7.4 6.7 0.0 3.2 2 1 1 3 3 2 0 TolA binding protein trimerisation TRAF_BIRC3_bd PF16673.5 EFO61844.1 - 0.058 13.2 2.4 5.3 6.9 0.1 3.3 1 1 2 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain Cast PF10174.9 EFO61844.1 - 0.066 11.4 7.0 0.12 10.6 7.0 1.4 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone HIP1_clath_bdg PF16515.5 EFO61844.1 - 0.073 13.7 6.1 6 7.5 0.3 3.9 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Taxilin PF09728.9 EFO61844.1 - 0.074 12.2 1.4 0.16 11.1 1.4 1.5 1 0 0 1 1 1 0 Myosin-like coiled-coil protein NPV_P10 PF05531.12 EFO61844.1 - 0.1 13.1 4.2 6.8 7.2 1.0 4.3 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein YabA PF06156.13 EFO61844.1 - 0.11 13.2 2.2 1 10.1 0.1 3.0 1 1 0 2 2 2 0 Initiation control protein YabA Filament PF00038.21 EFO61844.1 - 0.11 12.0 2.5 0.61 9.6 0.5 2.1 1 1 1 2 2 2 0 Intermediate filament protein SlyX PF04102.12 EFO61844.1 - 0.21 12.2 0.4 34 5.1 0.0 3.4 1 1 1 3 3 3 0 SlyX PI3K_P85_iSH2 PF16454.5 EFO61844.1 - 0.23 11.1 0.5 4.6 6.8 0.0 2.4 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TMF_TATA_bd PF12325.8 EFO61844.1 - 0.25 11.6 3.2 4.6 7.5 2.0 3.0 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Csm1_N PF18504.1 EFO61844.1 - 0.26 11.6 2.8 8.6 6.8 0.5 3.5 1 1 2 3 3 3 0 Csm1 N-terminal domain DivIC PF04977.15 EFO61844.1 - 0.32 10.8 2.7 9.6 6.1 0.0 3.2 2 1 1 3 3 2 0 Septum formation initiator DUF1664 PF07889.12 EFO61844.1 - 0.36 10.9 5.3 8.3 6.5 0.2 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 EFO61844.1 - 0.4 10.7 6.8 1.6 8.8 1.6 2.5 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus KxDL PF10241.9 EFO61844.1 - 0.66 10.3 2.0 2.2 8.6 0.4 2.5 1 1 0 2 2 2 0 Uncharacterized conserved protein Seryl_tRNA_N PF02403.22 EFO61844.1 - 0.77 10.0 12.0 0.67 10.2 0.2 3.6 2 1 2 4 4 3 0 Seryl-tRNA synthetase N-terminal domain Lebercilin PF15619.6 EFO61844.1 - 0.8 9.3 5.8 1.1 8.8 3.0 2.7 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Lectin_N PF03954.14 EFO61844.1 - 1.1 9.0 4.2 4.6 7.0 3.1 2.4 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain TMCO5 PF14992.6 EFO61844.1 - 1.4 8.4 5.5 2.2 7.8 0.2 2.2 1 1 1 2 2 2 0 TMCO5 family BLOC1_2 PF10046.9 EFO61844.1 - 1.8 8.9 5.6 5.5 7.4 0.8 2.9 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prefoldin_2 PF01920.20 EFO61844.1 - 2 8.4 8.4 14 5.7 0.2 3.2 2 1 1 3 3 3 0 Prefoldin subunit FAM76 PF16046.5 EFO61844.1 - 2.3 7.5 5.7 39 3.5 5.8 2.3 1 1 0 1 1 1 0 FAM76 protein TPR_MLP1_2 PF07926.12 EFO61844.1 - 2.4 8.2 7.3 2.6 8.1 0.9 2.6 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Bacillus_HBL PF05791.11 EFO61844.1 - 2.9 7.7 4.8 36 4.1 0.0 2.4 1 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) BRE1 PF08647.11 EFO61844.1 - 3.8 7.7 9.6 2.3 8.4 1.6 3.5 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase SWIRM PF04433.17 EFO61845.1 - 6.4e-07 29.6 0.3 2.7e-06 27.6 0.1 2.3 2 0 0 2 2 2 1 SWIRM domain DUF4094 PF13334.6 EFO61847.1 - 1.8 9.1 4.5 0.53 10.7 0.5 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) ANAPC4_WD40 PF12894.7 EFO61849.1 - 1.2e-05 25.6 0.0 0.036 14.4 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFO61849.1 - 0.047 14.6 0.8 4.8 8.2 0.0 4.2 6 0 0 6 6 6 0 WD domain, G-beta repeat Ribosomal_S5 PF00333.20 EFO61850.1 - 2.1e-24 85.2 2.1 3.7e-24 84.5 2.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EFO61850.1 - 2.5e-23 81.3 0.0 4.8e-23 80.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain CENP-H PF05837.12 EFO61851.1 - 0.0029 18.0 5.2 0.0029 18.0 5.2 4.0 2 1 1 3 3 3 1 Centromere protein H (CENP-H) DASH_Dam1 PF08653.10 EFO61851.1 - 0.21 11.4 1.6 2.3 8.1 0.1 3.1 3 1 1 4 4 4 0 DASH complex subunit Dam1 AKNA PF12443.8 EFO61851.1 - 1.7 9.4 5.4 0.63 10.7 1.0 2.6 2 1 0 2 2 2 0 AT-hook-containing transcription factor Peptidase_C12 PF01088.21 EFO61851.1 - 2.2 8.0 6.6 0.74 9.5 3.5 1.8 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase, family 1 Tup_N PF08581.10 EFO61851.1 - 6.2 7.2 12.1 0.83 10.0 2.6 3.5 3 0 0 3 3 3 0 Tup N-terminal DHHC PF01529.20 EFO61852.1 - 5.8e-29 100.9 9.8 5.8e-29 100.9 9.8 2.5 2 1 1 3 3 3 1 DHHC palmitoyltransferase PDEase_I PF00233.19 EFO61853.1 - 7e-06 25.9 2.0 9.8e-06 25.5 0.1 2.3 3 0 0 3 3 3 1 3'5'-cyclic nucleotide phosphodiesterase Baculo_PEP_C PF04513.12 EFO61853.1 - 0.066 13.2 0.2 0.17 12.0 0.2 1.6 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus RGS PF00615.19 EFO61853.1 - 0.1 12.9 0.6 2.9 8.2 0.4 3.2 2 1 0 2 2 2 0 Regulator of G protein signaling domain Aida_C2 PF14186.6 EFO61853.1 - 0.11 12.1 0.1 1.4 8.5 0.1 2.3 2 0 0 2 2 2 0 Cytoskeletal adhesion DUF3246 PF11596.8 EFO61853.1 - 0.24 10.8 0.1 0.41 10.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Ank_2 PF12796.7 EFO61854.1 - 6.6e-73 241.3 18.9 1.9e-11 44.4 0.0 8.5 3 3 5 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61854.1 - 1.8e-43 146.4 6.7 1.2e-08 35.3 0.7 12.1 6 4 6 12 12 12 9 Ankyrin repeats (many copies) Ank PF00023.30 EFO61854.1 - 2.5e-37 125.7 14.1 0.00056 20.3 0.1 13.9 14 1 0 14 14 14 8 Ankyrin repeat Ank_5 PF13857.6 EFO61854.1 - 2.5e-35 120.0 14.0 6e-07 29.6 0.0 11.4 7 3 5 12 12 12 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61854.1 - 2.6e-32 107.2 19.2 0.095 13.3 0.0 15.1 16 0 0 16 16 16 7 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO61854.1 - 6.1e-12 45.2 15.2 1.4e-11 44.1 15.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFO61854.1 - 7e-06 26.3 16.2 7e-06 26.3 16.2 1.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFO61854.1 - 0.0012 18.6 17.7 0.0027 17.5 17.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFO61854.1 - 0.53 10.3 19.7 0.23 11.5 16.9 1.9 2 0 0 2 2 2 0 zinc-RING finger domain Prok-RING_4 PF14447.6 EFO61854.1 - 0.88 9.5 15.7 1.8 8.5 15.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Prefoldin PF02996.17 EFO61857.1 - 1.4e-24 86.3 0.4 2.9e-24 85.3 0.1 1.6 1 1 1 2 2 2 1 Prefoldin subunit Prefoldin_2 PF01920.20 EFO61857.1 - 0.00026 20.9 0.7 0.027 14.4 0.0 2.4 2 1 0 2 2 2 1 Prefoldin subunit CC2-LZ PF16516.5 EFO61857.1 - 0.002 18.5 1.8 0.77 10.2 0.4 2.2 2 0 0 2 2 2 2 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator FlaC_arch PF05377.11 EFO61857.1 - 0.0049 17.2 3.9 0.95 9.9 0.1 2.4 2 0 0 2 2 2 2 Flagella accessory protein C (FlaC) KASH_CCD PF14662.6 EFO61857.1 - 0.0079 16.0 1.3 0.017 14.9 0.1 1.8 2 0 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH Osmo_CC PF08946.10 EFO61857.1 - 0.013 15.8 1.0 0.37 11.1 0.1 2.8 2 1 0 2 2 2 0 Osmosensory transporter coiled coil DUF2661 PF10860.8 EFO61857.1 - 0.016 15.3 0.2 0.044 13.9 0.0 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2661) Vps5 PF09325.10 EFO61857.1 - 0.019 14.5 1.6 0.031 13.8 0.2 1.8 2 0 0 2 2 2 0 Vps5 C terminal like GAS PF13851.6 EFO61857.1 - 0.065 12.6 1.6 0.67 9.3 0.1 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding BLOC1_2 PF10046.9 EFO61857.1 - 0.53 10.6 4.6 12 6.3 0.7 2.4 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2570 PF10828.8 EFO61858.1 - 0.0036 17.1 1.0 0.0036 17.1 1.0 3.3 4 0 0 4 4 4 1 Protein of unknown function (DUF2570) E2R135 PF11570.8 EFO61858.1 - 0.011 16.0 0.2 0.011 16.0 0.2 4.8 5 1 1 6 6 6 0 Coiled-coil receptor-binding R-domain of colicin E2 DUF4248 PF14053.6 EFO61858.1 - 0.14 12.2 1.5 1.9 8.6 0.1 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4248) HIP1_clath_bdg PF16515.5 EFO61858.1 - 0.75 10.4 38.9 0.45 11.2 4.3 7.0 5 2 2 7 7 7 0 Clathrin-binding domain of Huntingtin-interacting protein 1 MbeD_MobD PF04899.12 EFO61858.1 - 1.3 9.2 4.8 1.2 9.3 0.5 3.2 3 0 0 3 3 3 0 MbeD/MobD like DUF641 PF04859.12 EFO61858.1 - 2.4 8.5 35.6 1.2 9.4 0.6 7.2 3 1 3 6 6 6 0 Plant protein of unknown function (DUF641) Med15_fungi PF05397.12 EFO61858.1 - 4.9 7.4 7.2 3.7 7.8 0.1 3.6 3 0 0 3 3 3 0 Mediator complex subunit 15 Csm1_N PF18504.1 EFO61858.1 - 7.7 6.9 40.4 3.6 8.0 0.5 8.4 6 2 2 8 8 8 0 Csm1 N-terminal domain Pyr_redox_2 PF07992.14 EFO61859.1 - 1e-54 185.8 0.1 1.3e-54 185.4 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EFO61859.1 - 2.3e-15 56.8 0.0 8.2e-15 55.0 0.0 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EFO61859.1 - 4e-15 56.1 0.3 3e-14 53.3 0.0 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFO61859.1 - 6.7e-07 28.9 0.0 1.1e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFO61859.1 - 2e-05 24.4 0.4 0.31 10.6 0.0 3.2 3 0 0 3 3 3 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 EFO61859.1 - 6e-05 22.3 0.0 0.00013 21.3 0.0 1.5 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) TrkA_N PF02254.18 EFO61859.1 - 0.0028 17.9 0.0 2.8 8.2 0.0 2.8 2 0 0 2 2 2 2 TrkA-N domain Asp_Glu_race PF01177.22 EFO61859.1 - 0.018 14.9 0.2 0.06 13.2 0.1 1.9 2 0 0 2 2 2 0 Asp/Glu/Hydantoin racemase GIDA PF01134.22 EFO61859.1 - 0.026 13.6 0.5 9.2 5.2 0.0 3.1 3 0 0 3 3 3 0 Glucose inhibited division protein A HI0933_like PF03486.14 EFO61859.1 - 0.027 13.2 0.1 3.4 6.3 0.0 3.1 2 1 1 3 3 3 0 HI0933-like protein NAD_binding_8 PF13450.6 EFO61859.1 - 0.18 12.1 0.3 10 6.4 0.0 3.4 4 0 0 4 4 4 0 NAD(P)-binding Rossmann-like domain EF-hand_7 PF13499.6 EFO61861.1 - 0.052 14.0 0.6 1.3 9.6 0.0 2.8 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_6 PF13405.6 EFO61861.1 - 0.098 12.6 0.0 0.46 10.6 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain Pkinase PF00069.25 EFO61862.1 - 8.4e-21 74.5 0.0 1.9e-20 73.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61862.1 - 3.4e-16 59.3 0.0 5.4e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO61862.1 - 0.17 11.2 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Kinase-like VSP PF03302.13 EFO61863.1 - 1e-76 258.3 169.4 4.1e-39 134.6 24.9 5.8 1 1 3 4 4 4 3 Giardia variant-specific surface protein cEGF PF12662.7 EFO61863.1 - 0.055 13.4 0.7 0.055 13.4 0.7 7.2 7 0 0 7 7 7 0 Complement Clr-like EGF-like VSP PF03302.13 EFO61865.1 - 3e-15 56.0 206.9 1.1e-06 27.7 42.1 8.3 1 1 5 6 6 6 5 Giardia variant-specific surface protein RIFIN PF02009.16 EFO61865.1 - 0.01 15.8 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 0 Rifin MLANA PF14991.6 EFO61865.1 - 0.018 15.3 0.1 0.043 14.1 0.1 1.6 1 0 0 1 1 1 0 Protein melan-A cEGF PF12662.7 EFO61865.1 - 0.083 12.8 0.3 0.083 12.8 0.3 11.2 12 1 0 12 12 12 0 Complement Clr-like EGF-like ASFV_J13L PF05568.11 EFO61865.1 - 0.23 11.2 1.7 0.42 10.3 0.2 2.1 2 0 0 2 2 2 0 African swine fever virus J13L protein EGF_2 PF07974.13 EFO61866.1 - 6.8e-06 26.3 280.7 0.0023 18.2 10.3 23.2 23 1 0 23 23 23 15 EGF-like domain hEGF PF12661.7 EFO61866.1 - 0.0036 17.9 7.3 0.0036 17.9 7.3 23.0 24 0 0 24 24 24 7 Human growth factor-like EGF Gloverin PF10793.9 EFO61866.1 - 0.12 12.3 0.3 0.85 9.5 0.1 2.2 1 1 1 2 2 2 0 Gloverin-like protein DUF1180 PF06679.12 EFO61866.1 - 0.19 12.1 0.0 0.42 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) EGF PF00008.27 EFO61866.1 - 0.35 11.2 235.6 0.019 15.3 4.4 22.7 22 0 0 22 22 22 0 EGF-like domain EGF PF00008.27 EFO61867.1 - 2.6e-05 24.4 26.5 0.002 18.4 6.8 6.7 5 3 2 7 7 7 3 EGF-like domain Plasmod_Pvs28 PF06247.11 EFO61867.1 - 3.5e-05 24.0 4.3 3.5e-05 24.0 4.3 5.5 5 1 0 5 5 5 3 Pvs28 EGF domain hEGF PF12661.7 EFO61867.1 - 0.013 16.1 6.3 0.013 16.1 6.3 8.6 8 3 1 9 9 9 0 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 EFO61867.1 - 0.026 14.6 1.3 0.026 14.6 1.3 4.9 4 0 0 4 4 4 0 MSP1 EGF domain 1 cEGF PF12662.7 EFO61867.1 - 0.05 13.5 3.0 0.05 13.5 3.0 6.2 5 3 0 5 5 5 0 Complement Clr-like EGF-like EGF_CA PF07645.15 EFO61867.1 - 0.19 12.0 54.9 0.11 12.7 9.1 5.9 4 2 1 5 5 5 0 Calcium-binding EGF domain EGF_2 PF07974.13 EFO61867.1 - 0.31 11.4 61.0 0.064 13.6 8.1 6.0 5 1 0 5 5 5 0 EGF-like domain VSP PF03302.13 EFO61868.1 - 1.1e-96 324.1 299.9 6.8e-41 140.4 27.0 11.1 1 1 9 11 11 11 9 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO61868.1 - 0.27 11.3 0.5 1.6 8.8 0.0 2.6 2 0 0 2 2 2 0 Podoplanin Ank_2 PF12796.7 EFO61869.1 - 1.9e-208 675.7 51.5 3.4e-19 69.2 0.1 15.8 1 1 16 19 19 19 19 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61869.1 - 4.7e-120 390.6 24.8 2.5e-08 34.3 0.3 23.1 13 5 10 24 24 24 21 Ankyrin repeats (many copies) Ank PF00023.30 EFO61869.1 - 4.4e-100 324.1 12.3 0.0004 20.7 0.0 27.6 26 2 1 27 27 27 20 Ankyrin repeat Ank_5 PF13857.6 EFO61869.1 - 4.9e-90 294.4 44.4 8.3e-06 26.0 0.0 26.0 6 4 22 29 29 29 20 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61869.1 - 4.6e-87 275.4 20.3 0.007 16.8 0.0 28.9 30 0 0 30 30 30 20 Ankyrin repeat Pkinase PF00069.25 EFO61869.1 - 3.1e-35 121.8 0.0 1.3e-33 116.5 0.0 2.8 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61869.1 - 1.1e-22 80.6 0.0 5.9e-22 78.2 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Phage_T7_Capsid PF05396.11 EFO61869.1 - 5.5e-05 23.5 0.3 0.29 11.5 0.0 4.8 3 2 1 4 4 4 1 Phage T7 capsid assembly protein HemY_N PF07219.13 EFO61869.1 - 0.00031 20.9 2.2 0.13 12.4 0.7 3.3 2 0 0 2 2 2 2 HemY protein N-terminus Kinase-like PF14531.6 EFO61869.1 - 0.053 12.8 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 Kinase-like Ank_2 PF12796.7 EFO61870.1 - 2.4e-28 98.6 4.4 1.1e-09 38.7 0.1 6.6 5 1 1 6 6 6 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO61870.1 - 9.2e-24 83.5 5.2 1.6e-11 44.5 0.1 7.4 4 1 3 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61870.1 - 6.2e-21 72.3 9.8 5.4e-06 26.3 0.0 10.2 9 0 0 9 9 9 5 Ankyrin repeat Ank PF00023.30 EFO61870.1 - 3.2e-18 65.3 12.3 6.4e-06 26.4 0.0 9.5 11 0 0 11 11 11 5 Ankyrin repeat Ank_5 PF13857.6 EFO61870.1 - 5.1e-17 61.7 7.0 2.6e-11 43.5 0.7 6.3 7 0 0 7 7 7 3 Ankyrin repeats (many copies) tRNA_bind PF01588.20 EFO61870.1 - 0.072 13.2 0.0 0.72 10.0 0.0 2.4 1 1 1 2 2 2 0 Putative tRNA binding domain Sfi1 PF08457.10 EFO61871.1 - 0.00029 19.5 24.2 0.0057 15.3 2.5 3.5 3 0 0 3 3 3 3 Sfi1 spindle body protein Ank_2 PF12796.7 EFO61872.1 - 3.9e-50 168.4 6.5 1.7e-16 60.6 0.0 5.4 3 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61872.1 - 2.8e-32 110.4 16.2 5.8e-07 29.7 0.2 8.2 4 3 5 9 9 8 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO61872.1 - 1.7e-28 97.7 6.8 0.00011 22.5 0.1 8.0 7 1 1 8 8 8 6 Ankyrin repeat Ank_3 PF13606.6 EFO61872.1 - 1.2e-25 86.7 5.7 0.00064 20.0 0.0 8.9 9 0 0 9 9 8 5 Ankyrin repeat Ank_4 PF13637.6 EFO61872.1 - 1.2e-21 76.8 5.3 6.5e-05 23.4 0.0 6.4 4 1 0 5 5 5 3 Ankyrin repeats (many copies) FPP PF05911.11 EFO61872.1 - 2e-08 33.0 8.4 2.5e-08 32.6 8.4 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil ERM PF00769.19 EFO61872.1 - 1.5e-05 25.0 14.1 1.5e-05 25.0 14.1 2.2 2 0 0 2 2 2 1 Ezrin/radixin/moesin family APG6_N PF17675.1 EFO61872.1 - 0.00027 21.5 25.1 0.0024 18.4 15.8 2.5 2 0 0 2 2 2 2 Apg6 coiled-coil region GAS PF13851.6 EFO61872.1 - 0.0043 16.4 23.5 0.015 14.7 2.4 2.3 2 0 0 2 2 2 2 Growth-arrest specific micro-tubule binding DUF5344 PF17279.2 EFO61872.1 - 0.023 15.3 3.3 1.9 9.1 0.1 3.6 3 0 0 3 3 3 0 Family of unknown function (DUF5344) Cluap1 PF10234.9 EFO61872.1 - 0.097 12.1 14.5 0.9 8.9 0.4 2.3 2 0 0 2 2 2 0 Clusterin-associated protein-1 MutS_III PF05192.18 EFO61872.1 - 0.13 12.5 5.7 0.3 11.3 5.7 1.7 1 0 0 1 1 1 0 MutS domain III Spc7 PF08317.11 EFO61872.1 - 0.17 10.7 25.3 0.018 14.0 14.5 2.3 1 1 2 3 3 3 0 Spc7 kinetochore protein TACC_C PF05010.14 EFO61872.1 - 0.18 11.5 22.0 0.098 12.4 2.0 2.9 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal CheZ PF04344.13 EFO61872.1 - 0.19 11.7 9.0 0.042 13.8 4.4 2.2 1 1 1 2 2 2 0 Chemotaxis phosphatase, CheZ DivIVA PF05103.13 EFO61872.1 - 0.33 11.0 16.8 1.2 9.2 1.2 3.5 2 1 0 3 3 3 0 DivIVA protein Seryl_tRNA_N PF02403.22 EFO61872.1 - 0.37 11.0 22.7 0.21 11.8 7.6 3.3 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain FUSC PF04632.12 EFO61872.1 - 0.38 9.2 4.0 0.72 8.3 4.0 1.5 1 0 0 1 1 1 0 Fusaric acid resistance protein family CENP-F_leu_zip PF10473.9 EFO61872.1 - 0.65 10.0 29.1 1.8 8.6 11.7 2.9 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF948 PF06103.11 EFO61872.1 - 0.7 10.2 14.9 0.29 11.4 1.2 3.7 1 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) KASH_CCD PF14662.6 EFO61872.1 - 0.75 9.6 30.2 0.21 11.4 4.9 2.4 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Fez1 PF06818.15 EFO61872.1 - 1.2 9.5 24.2 1.7 9.0 9.3 2.4 1 1 1 2 2 2 0 Fez1 TMF_TATA_bd PF12325.8 EFO61872.1 - 1.7 8.9 29.9 2.4 8.4 4.3 3.4 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Filament PF00038.21 EFO61872.1 - 2.7 7.5 27.8 1.1 8.8 14.9 2.9 2 1 1 3 3 3 0 Intermediate filament protein KELK PF15796.5 EFO61872.1 - 3 8.4 19.1 2.7 8.5 1.3 3.5 3 0 0 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Macoilin PF09726.9 EFO61872.1 - 3.5 6.1 19.5 7 5.1 19.2 1.5 1 1 0 1 1 1 0 Macoilin family DHR10 PF18595.1 EFO61872.1 - 5.9 7.0 30.1 0.27 11.3 3.2 3.7 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain Yuri_gagarin PF15934.5 EFO61872.1 - 7.1 6.4 18.7 68 3.2 18.9 2.1 1 1 0 1 1 1 0 Yuri gagarin Tup_N PF08581.10 EFO61872.1 - 7.4 7.0 15.9 0.21 11.9 2.0 3.6 1 1 3 4 4 4 0 Tup N-terminal CENP-H PF05837.12 EFO61872.1 - 7.4 7.0 27.4 9.9 6.6 9.1 3.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) AAA_13 PF13166.6 EFO61872.1 - 8.1 5.0 16.4 11 4.5 16.4 1.1 1 0 0 1 1 1 0 AAA domain EzrA PF06160.12 EFO61872.1 - 9.2 4.3 22.3 31 2.6 22.3 1.6 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA YabA PF06156.13 EFO61872.1 - 9.4 6.9 26.3 8.5 7.1 3.8 3.9 2 1 2 4 4 3 0 Initiation control protein YabA Ank_2 PF12796.7 EFO61873.1 - 2.2e-46 156.4 8.5 5.3e-12 46.2 0.1 5.1 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 EFO61873.1 - 1.3e-27 95.0 6.1 0.00047 20.5 0.0 8.7 7 1 1 8 8 8 7 Ankyrin repeat Ank_3 PF13606.6 EFO61873.1 - 4e-27 91.3 2.3 0.0057 17.1 0.0 9.0 9 0 0 9 9 8 5 Ankyrin repeat Ank_5 PF13857.6 EFO61873.1 - 2e-25 88.5 8.2 0.00036 20.7 0.0 7.7 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61873.1 - 7.2e-23 80.7 1.7 0.00028 21.4 0.0 6.5 6 0 0 6 6 6 5 Ankyrin repeats (many copies) Leu_zip PF15294.6 EFO61873.1 - 0.0018 17.8 19.2 0.0018 17.8 19.2 2.2 2 1 1 3 3 3 1 Leucine zipper Syntaxin_2 PF14523.6 EFO61873.1 - 0.0039 17.5 12.6 0.04 14.3 4.1 2.7 2 1 0 2 2 2 2 Syntaxin-like protein TolA_bind_tri PF16331.5 EFO61873.1 - 0.01 15.9 18.9 0.43 10.7 4.9 3.3 3 0 0 3 3 3 0 TolA binding protein trimerisation TMF_TATA_bd PF12325.8 EFO61873.1 - 0.015 15.5 24.4 0.044 14.0 4.8 3.6 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF4745 PF15923.5 EFO61873.1 - 0.021 14.8 0.4 3.5 7.6 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4745) Bacillus_HBL PF05791.11 EFO61873.1 - 0.037 13.9 10.1 0.27 11.0 6.3 2.5 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF1465 PF07323.12 EFO61873.1 - 0.099 12.5 0.2 0.099 12.5 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) PFEMP PF03011.15 EFO61873.1 - 0.2 12.3 7.5 0.56 10.9 7.5 1.8 1 0 0 1 1 1 0 PFEMP DBL domain Herpes_UL6 PF01763.16 EFO61873.1 - 0.61 8.5 15.4 0.0065 15.1 5.2 2.1 1 1 0 2 2 2 0 Herpesvirus UL6 like FlaC_arch PF05377.11 EFO61873.1 - 0.67 10.4 13.1 0.85 10.1 0.4 3.6 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Fez1 PF06818.15 EFO61873.1 - 1.2 9.5 25.6 0.26 11.7 20.8 2.1 2 0 0 2 2 2 0 Fez1 TSC22 PF01166.18 EFO61873.1 - 2 8.8 9.4 4.3 7.7 0.9 3.3 2 0 0 2 2 2 0 TSC-22/dip/bun family NPV_P10 PF05531.12 EFO61873.1 - 3.2 8.3 7.6 9.6 6.8 0.3 3.1 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Ank_2 PF12796.7 EFO61874.1 - 2.2e-24 85.9 0.3 1.6e-09 38.2 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61874.1 - 1.3e-12 47.6 3.4 0.0012 19.1 0.1 4.6 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO61874.1 - 2.6e-12 46.6 1.8 0.13 12.7 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EFO61874.1 - 2.1e-11 43.0 1.0 0.12 13.0 0.0 5.4 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 EFO61874.1 - 3.9e-10 40.0 1.2 0.00045 20.7 0.1 4.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) VSP PF03302.13 EFO61875.1 - 0.0036 16.2 1.2 0.0036 16.2 1.2 3.4 3 1 0 3 3 3 1 Giardia variant-specific surface protein Cytochrome_cB PF11783.8 EFO61875.1 - 0.052 13.4 0.8 0.16 11.8 0.8 1.8 1 0 0 1 1 1 0 Cytochrome c bacterial Trypan_PARP PF05887.11 EFO61875.1 - 0.35 10.8 4.2 0.69 9.9 4.2 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) zf-C2H2_jaz PF12171.8 EFO61876.1 - 3.3e-06 27.2 0.7 4.5e-06 26.8 0.1 1.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFO61876.1 - 0.0014 18.9 0.1 0.0024 18.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EFO61876.1 - 0.0038 17.5 0.0 0.0043 17.3 0.0 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EFO61876.1 - 0.0059 17.0 0.1 0.011 16.1 0.1 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFO61876.1 - 0.017 15.9 0.1 0.036 14.9 0.1 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger TatD_DNase PF01026.21 EFO61877.1 - 7.3e-24 84.5 0.0 1.1e-23 84.0 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase ANTAR PF03861.14 EFO61877.1 - 0.086 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 ANTAR domain VCPO_N PF17897.1 EFO61878.1 - 0.016 15.0 0.1 0.062 13.1 0.0 2.0 2 0 0 2 2 2 0 Vanadium chloroperoxidase N-terminal domain RIO1 PF01163.22 EFO61879.1 - 5.6e-10 39.1 0.0 8.6e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EFO61879.1 - 1.2e-08 35.2 0.1 6.5e-06 26.2 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 EFO61879.1 - 2.8e-08 33.5 0.0 3.4e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EFO61879.1 - 7.3e-07 28.8 0.0 0.0001 21.7 0.0 2.1 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EFO61879.1 - 1.5e-05 24.7 0.1 5e-05 23.0 0.1 1.7 1 1 1 2 2 2 1 Choline/ethanolamine kinase Pkinase_Tyr PF07714.17 EFO61879.1 - 0.00017 21.0 0.0 0.0002 20.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EcKinase PF02958.20 EFO61879.1 - 0.018 14.3 0.1 0.026 13.9 0.1 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase DUF1679 PF07914.11 EFO61879.1 - 0.12 11.2 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Staygreen PF12638.7 EFO61880.1 - 0.012 15.4 0.1 2.2 8.1 0.0 2.4 2 0 0 2 2 2 0 Staygreen protein DNA_pol_E_B PF04042.16 EFO61881.1 - 3e-13 49.6 0.6 6.3e-13 48.6 0.6 1.5 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B AAA PF00004.29 EFO61882.1 - 2.8e-39 134.6 0.0 4.4e-39 133.9 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EFO61882.1 - 2e-18 66.2 0.1 1.4e-17 63.4 0.0 2.5 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EFO61882.1 - 1e-09 38.1 0.4 4.1e-09 36.1 0.0 2.3 2 0 0 2 2 2 1 AAA+ lid domain RuvB_N PF05496.12 EFO61882.1 - 1.3e-06 28.2 0.0 4e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFO61882.1 - 1.3e-05 25.7 0.1 0.035 14.5 0.0 2.6 1 1 1 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EFO61882.1 - 2.1e-05 24.8 0.3 0.027 14.7 0.1 2.4 1 1 1 2 2 2 2 AAA domain DUF815 PF05673.13 EFO61882.1 - 0.00012 21.3 0.0 0.00022 20.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TIP49 PF06068.13 EFO61882.1 - 0.00019 20.7 0.0 0.00035 19.9 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_2 PF07724.14 EFO61882.1 - 0.00033 20.8 0.0 0.00077 19.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 EFO61882.1 - 0.00078 19.5 0.0 0.0015 18.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EFO61882.1 - 0.0011 19.0 0.0 0.01 15.8 0.0 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) MIT PF04212.18 EFO61882.1 - 0.0015 18.5 0.2 0.0015 18.5 0.2 2.4 3 0 0 3 3 2 1 MIT (microtubule interacting and transport) domain AAA_33 PF13671.6 EFO61882.1 - 0.0016 18.6 0.0 0.0045 17.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFO61882.1 - 0.0017 18.9 0.0 0.0051 17.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EFO61882.1 - 0.0033 17.2 0.0 0.0067 16.2 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_25 PF13481.6 EFO61882.1 - 0.015 14.9 0.7 0.77 9.3 0.1 2.5 1 1 1 2 2 2 0 AAA domain Torsin PF06309.11 EFO61882.1 - 0.023 14.8 0.0 0.045 13.9 0.0 1.4 1 0 0 1 1 1 0 Torsin AAA_17 PF13207.6 EFO61882.1 - 0.029 14.8 0.0 0.062 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFO61882.1 - 0.032 14.6 0.0 0.38 11.2 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.6 EFO61882.1 - 0.047 13.9 0.0 0.094 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFO61882.1 - 0.082 12.6 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Pilus_CpaD PF09476.10 EFO61882.1 - 0.095 12.4 0.3 0.18 11.5 0.1 1.6 2 0 0 2 2 2 0 Pilus biogenesis CpaD protein (pilus_cpaD) Zot PF05707.12 EFO61882.1 - 0.098 12.3 0.0 0.28 10.8 0.0 1.7 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) Mg_chelatase PF01078.21 EFO61882.1 - 0.13 11.6 0.0 0.44 9.9 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 EFO61882.1 - 0.15 11.5 0.0 0.83 9.1 0.0 2.1 2 1 0 2 2 2 0 P-loop containing dynein motor region NFACT-R_1 PF05670.13 EFO61883.1 - 4.4e-39 133.5 0.0 7.5e-39 132.8 0.0 1.4 1 0 0 1 1 1 1 NFACT protein RNA binding domain NPV_P10 PF05531.12 EFO61884.1 - 0.0038 17.7 4.1 0.0098 16.3 1.8 2.2 2 0 0 2 2 2 1 Nucleopolyhedrovirus P10 protein TMF_DNA_bd PF12329.8 EFO61884.1 - 0.004 17.1 10.4 0.13 12.2 1.8 3.0 2 1 0 3 3 3 2 TATA element modulatory factor 1 DNA binding DUF948 PF06103.11 EFO61884.1 - 0.047 13.9 5.4 0.2 11.9 0.4 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF5304 PF17230.2 EFO61884.1 - 0.076 13.2 0.4 0.15 12.3 0.2 1.5 1 1 1 2 2 2 0 Family of unknown function (DUF5304) Syntaxin_2 PF14523.6 EFO61884.1 - 0.15 12.5 6.7 0.24 11.8 2.6 2.1 2 0 0 2 2 2 0 Syntaxin-like protein Bacillus_HBL PF05791.11 EFO61884.1 - 0.3 10.9 3.6 0.27 11.1 2.4 1.5 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) FapA PF03961.13 EFO61884.1 - 0.35 9.4 4.0 0.43 9.1 3.7 1.3 1 1 0 1 1 1 0 Flagellar Assembly Protein A Spc7 PF08317.11 EFO61884.1 - 0.53 9.1 10.2 0.056 12.3 3.2 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein UBM PF14377.6 EFO61884.1 - 0.63 9.6 3.8 5 6.7 0.2 3.2 3 0 0 3 3 3 0 Ubiquitin binding region DUF1664 PF07889.12 EFO61884.1 - 0.77 9.8 4.7 0.53 10.3 1.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) kleA_kleC PF17383.2 EFO61884.1 - 0.84 10.0 3.6 6 7.3 0.1 2.4 2 1 0 2 2 2 0 Uncharacterized KorC regulated protein A TSC22 PF01166.18 EFO61884.1 - 1.7 9.0 9.9 0.59 10.5 0.6 3.0 2 1 1 3 3 3 0 TSC-22/dip/bun family Mod_r PF07200.13 EFO61884.1 - 2.4 8.3 8.9 1.6 8.8 1.0 2.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein LMBR1 PF04791.16 EFO61884.1 - 2.9 6.7 3.8 3.3 6.5 3.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein TBCA PF02970.16 EFO61885.1 - 9e-13 48.4 7.8 1.9e-12 47.3 6.6 1.9 1 1 1 2 2 2 2 Tubulin binding cofactor A NBP1 PF08537.10 EFO61885.1 - 0.045 13.2 2.3 0.056 12.9 2.3 1.2 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 ATP_Ca_trans_C PF12424.8 EFO61885.1 - 0.12 12.9 0.0 0.28 11.7 0.0 1.7 2 0 0 2 2 2 0 Plasma membrane calcium transporter ATPase C terminal Wbp11 PF09429.10 EFO61885.1 - 0.67 10.4 10.5 3 8.3 3.4 2.1 1 1 1 2 2 2 0 WW domain binding protein 11 CCDC53 PF10152.9 EFO61886.1 - 1.1 9.7 0.0 1.1 9.7 0.0 2.9 4 0 0 4 4 4 0 Subunit CCDC53 of WASH complex BBS1 PF14779.6 EFO61887.1 - 9.2e-09 35.1 0.4 7.3e-08 32.2 0.0 2.5 3 1 0 3 3 3 1 Ciliary BBSome complex subunit 1 MetOD2 PF18548.1 EFO61887.1 - 0.0032 17.5 0.0 0.015 15.4 0.1 2.0 2 0 0 2 2 2 1 Metanogen output domain 2 Pkinase PF00069.25 EFO61888.1 - 2.5e-62 210.7 0.0 4.7e-62 209.7 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61888.1 - 3.9e-41 141.0 0.0 6.6e-41 140.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO61888.1 - 2.1e-06 27.3 0.0 1.2e-05 24.8 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFO61888.1 - 8.1e-06 24.9 0.0 1.8e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFO61888.1 - 0.0021 17.4 0.0 0.0055 16.1 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4100 PF13352.6 EFO61888.1 - 0.059 13.1 0.6 0.1 12.3 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4100) YrbL-PhoP_reg PF10707.9 EFO61888.1 - 0.089 12.3 0.1 0.17 11.4 0.1 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DUF4368 PF14287.6 EFO61888.1 - 0.1 12.9 0.2 0.24 11.7 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4368) zf-C3HC4_3 PF13920.6 EFO61891.1 - 1.1e-10 41.2 5.0 1.6e-10 40.6 5.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFO61891.1 - 3.7e-09 36.8 7.4 5.5e-09 36.2 7.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EFO61891.1 - 7.2e-09 35.5 4.3 1.7e-08 34.3 4.3 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFO61891.1 - 2.3e-08 33.8 8.3 3.5e-08 33.2 8.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFO61891.1 - 7.3e-07 28.9 6.7 1.3e-06 28.2 6.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFO61891.1 - 2.2e-06 27.5 7.1 9.8e-06 25.4 7.6 1.8 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EFO61891.1 - 2.6e-06 27.5 9.7 5.5e-06 26.4 9.7 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EFO61891.1 - 4.6e-05 23.2 6.1 0.00012 21.8 6.2 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EFO61891.1 - 0.0021 18.3 7.3 0.0064 16.8 7.4 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EFO61891.1 - 0.0059 16.6 2.1 0.0097 15.9 2.1 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Rtf2 PF04641.12 EFO61891.1 - 0.016 14.6 0.1 0.024 14.0 0.1 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger Zn_ribbon_17 PF17120.5 EFO61891.1 - 0.017 14.7 4.5 0.029 14.0 4.5 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-Nse PF11789.8 EFO61891.1 - 0.019 14.7 1.3 0.037 13.8 1.3 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-MIZ PF02891.20 EFO61891.1 - 0.16 11.7 6.0 0.29 10.9 6.0 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger TerY_C PF15616.6 EFO61891.1 - 0.21 11.7 2.2 0.37 10.9 2.2 1.3 1 0 0 1 1 1 0 TerY-C metal binding domain RINGv PF12906.7 EFO61891.1 - 0.32 11.2 6.3 1.1 9.4 6.3 1.9 1 1 0 1 1 1 0 RING-variant domain zf-P11 PF03854.14 EFO61891.1 - 0.91 9.2 9.6 3.3 7.4 9.7 1.8 1 1 0 1 1 1 0 P-11 zinc finger zf-RING_6 PF14835.6 EFO61891.1 - 1.5 8.7 5.6 4.7 7.2 5.6 1.8 1 1 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_11 PF17123.5 EFO61891.1 - 6.8 6.5 7.0 14 5.6 4.1 2.5 2 1 0 2 2 2 0 RING-like zinc finger EF-hand_6 PF13405.6 EFO61893.1 - 0.0016 18.2 1.3 0.11 12.5 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 EFO61893.1 - 0.01 16.3 0.1 1 9.9 0.0 2.9 2 0 0 2 2 2 0 EF-hand domain pair DUF3618 PF12277.8 EFO61893.1 - 1.1 9.6 3.2 3.3 8.1 1.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3618) EF-hand_6 PF13405.6 EFO61894.1 - 0.014 15.3 1.9 45 4.4 0.1 4.5 5 0 0 5 5 5 0 EF-hand domain ParD_antitoxin PF03693.14 EFO61894.1 - 0.08 13.4 0.1 0.28 11.6 0.1 1.9 1 0 0 1 1 1 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH FANCF PF11107.8 EFO61894.1 - 0.081 12.1 0.7 0.2 10.9 0.3 1.9 2 0 0 2 2 2 0 Fanconi anemia group F protein (FANCF) EF-hand_1 PF00036.32 EFO61894.1 - 0.22 11.2 1.0 7.1 6.4 0.0 3.8 4 0 0 4 4 4 0 EF hand Myb_DNA-binding PF00249.31 EFO61896.1 - 1.9e-24 85.6 0.9 6.4e-12 45.5 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFO61896.1 - 3.1e-17 62.6 0.0 1.3e-12 47.7 0.0 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 EFO61896.1 - 0.02 14.9 0.0 1.7 8.7 0.0 2.3 2 0 0 2 2 2 0 SLIDE Myb_DNA-bind_4 PF13837.6 EFO61896.1 - 0.066 13.6 1.5 5.8 7.4 0.1 2.9 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain CompInhib_SCIN PF11546.8 EFO61897.1 - 0.073 13.1 1.1 0.25 11.4 0.1 2.5 2 1 1 3 3 3 0 Staphylococcal complement inhibitor SCIN zf-Di19 PF05605.12 EFO61898.1 - 0.15 12.3 0.2 0.43 10.9 0.1 1.7 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Ribosomal_L7Ae PF01248.26 EFO61899.1 - 8.7e-17 60.6 0.7 1.1e-16 60.3 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Aspzincin_M35 PF14521.6 EFO61899.1 - 0.13 12.8 0.2 0.16 12.5 0.2 1.3 1 0 0 1 1 1 0 Lysine-specific metallo-endopeptidase Ank_2 PF12796.7 EFO61900.1 - 4e-36 123.5 10.1 8.7e-11 42.3 2.2 5.8 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61900.1 - 3e-21 75.2 5.6 0.00028 21.1 0.0 7.4 2 1 4 7 7 7 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61900.1 - 1.8e-17 63.4 4.8 0.0012 19.4 0.0 6.9 4 1 2 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61900.1 - 5.2e-14 51.0 9.3 0.89 10.3 0.0 10.1 11 0 0 11 11 11 4 Ankyrin repeat Ank PF00023.30 EFO61900.1 - 7.6e-13 48.3 2.1 0.91 10.1 0.0 8.0 8 0 0 8 8 8 3 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO61900.1 - 5.7e-07 29.3 16.5 5.7e-07 29.3 16.5 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO61900.1 - 0.011 15.6 13.2 0.023 14.6 13.2 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 L1R_F9L PF02442.17 EFO61900.1 - 0.5 10.2 4.0 0.16 11.8 0.2 2.1 3 0 0 3 3 3 0 Lipid membrane protein of large eukaryotic DNA viruses Pkinase PF00069.25 EFO61901.1 - 4.8e-27 95.0 0.0 6.9e-27 94.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61901.1 - 4.5e-15 55.6 0.0 9.6e-15 54.6 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase DUF3877 PF12993.7 EFO61901.1 - 0.59 10.0 4.1 0.35 10.7 1.9 1.7 2 0 0 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3877) SRR1 PF07985.12 EFO61902.1 - 9.1e-12 44.8 0.0 1.8e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 SRR1 Mtp PF03821.16 EFO61902.1 - 0.032 13.8 0.3 0.048 13.2 0.3 1.2 1 0 0 1 1 1 0 Golgi 4-transmembrane spanning transporter VSP PF03302.13 EFO61904.1 - 5.9e-17 61.6 193.9 1.4e-05 24.1 20.0 7.1 1 1 5 7 7 7 7 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO61904.1 - 0.003 17.7 7.6 0.003 17.7 7.6 11.5 1 1 8 11 11 11 5 Furin-like repeat, cysteine-rich TPH PF13868.6 EFO61905.1 - 9.4e-09 34.2 107.5 9.4e-09 34.2 107.5 1.9 1 1 0 2 2 2 1 Trichohyalin-plectin-homology domain HSP70 PF00012.20 EFO61907.1 - 6.1e-14 51.1 0.0 3.5e-12 45.3 0.0 2.3 2 1 0 2 2 2 2 Hsp70 protein U6-snRNA_bdg PF10596.9 EFO61908.1 - 5.4e-64 214.9 1.5 1.7e-63 213.3 0.2 2.5 3 0 0 3 3 3 1 U6-snRNA interacting domain of PrP8 PROCN PF08083.11 EFO61908.1 - 1.5e-62 211.6 3.3 3.6e-62 210.4 3.3 1.5 1 1 0 1 1 1 1 PROCN (NUC071) domain U5_2-snRNA_bdg PF10597.9 EFO61908.1 - 1.3e-34 119.1 0.0 3.6e-34 117.7 0.0 1.7 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PRP8_domainIV PF12134.8 EFO61908.1 - 6.7e-21 75.0 0.0 1.3e-20 74.1 0.0 1.3 1 0 0 1 1 1 1 PRP8 domain IV core PRO8NT PF08082.11 EFO61908.1 - 1.6e-11 44.3 0.0 5.6e-11 42.6 0.0 1.9 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain RRM_4 PF10598.9 EFO61908.1 - 4.8e-06 26.8 0.3 1.2e-05 25.5 0.3 1.7 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 Ank_2 PF12796.7 EFO61910.1 - 1.1e-54 182.9 0.6 3.1e-17 62.9 0.1 3.6 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EFO61910.1 - 2.5e-36 122.5 0.9 4.1e-05 23.8 0.1 7.9 7 1 1 8 8 8 6 Ankyrin repeat Ank_4 PF13637.6 EFO61910.1 - 4.3e-36 122.8 7.8 5.6e-11 42.8 0.1 6.9 5 2 1 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61910.1 - 2.8e-34 113.2 1.1 0.00094 19.5 0.0 8.0 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 EFO61910.1 - 3.2e-34 116.5 14.2 6.8e-07 29.5 0.1 7.2 3 2 4 7 7 7 7 Ankyrin repeats (many copies) DUF5639 PF18690.1 EFO61910.1 - 0.0032 17.6 0.7 5.4 7.3 0.0 3.4 1 1 2 3 3 3 2 Family of unknown function (DUF5639) TED PF08341.11 EFO61910.1 - 0.011 16.1 0.1 0.23 11.8 0.1 2.6 1 1 0 1 1 1 0 Thioester domain ERAP1_C PF11838.8 EFO61910.1 - 0.14 11.6 0.9 33 3.9 0.0 3.3 2 2 1 3 3 3 0 ERAP1-like C-terminal domain Imm_superinfect PF14373.6 EFO61910.1 - 3.1 7.8 13.8 45 4.1 0.0 6.1 7 1 0 7 7 7 0 Superinfection immunity protein WD40 PF00400.32 EFO61912.1 - 1.2e-06 29.1 4.0 0.15 13.0 0.2 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat Pkinase PF00069.25 EFO61913.1 - 5.9e-58 196.3 0.0 9e-58 195.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61913.1 - 1.1e-39 136.4 0.0 1.6e-39 135.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFO61913.1 - 0.0055 15.5 0.9 0.059 12.1 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase NifU_N PF01592.16 EFO61914.1 - 1.2e-47 161.3 0.0 1.5e-47 161.0 0.0 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain Myb_DNA-bind_7 PF15963.5 EFO61918.1 - 0.027 14.4 0.3 0.059 13.3 0.3 1.5 1 0 0 1 1 1 0 Myb DNA-binding like Zip PF02535.22 EFO61920.1 - 9.3e-38 130.3 11.1 1.1e-37 130.0 11.1 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter CybS PF05328.12 EFO61920.1 - 1.4 8.6 3.8 1.5 8.5 0.3 2.2 1 1 1 2 2 2 0 CybS, succinate dehydrogenase cytochrome B small subunit Robl_LC7 PF03259.17 EFO61922.1 - 9.6e-20 70.2 0.0 1.1e-19 70.0 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 EFO61922.1 - 0.00011 22.0 0.0 0.00012 22.0 0.0 1.2 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 Tektin PF03148.14 EFO61923.1 - 2.6e-05 23.1 5.5 2.6e-05 23.1 5.5 5.1 1 1 4 5 5 5 3 Tektin family DUF4201 PF13870.6 EFO61923.1 - 3.4e-05 23.7 40.5 0.011 15.5 7.8 4.6 3 2 0 4 4 4 2 Domain of unknown function (DUF4201) DUF1664 PF07889.12 EFO61923.1 - 0.00025 21.1 0.2 0.00025 21.1 0.2 4.9 3 2 3 6 6 5 2 Protein of unknown function (DUF1664) Filament PF00038.21 EFO61923.1 - 0.00027 20.6 39.4 0.014 15.0 21.3 3.6 1 1 2 3 3 3 2 Intermediate filament protein HOOK PF05622.12 EFO61923.1 - 0.00032 19.0 43.4 0.034 12.3 9.3 3.5 1 1 0 3 3 3 3 HOOK protein UPF0242 PF06785.11 EFO61923.1 - 0.00046 20.4 37.8 0.0076 16.4 11.2 3.4 3 0 0 3 3 3 3 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 EFO61923.1 - 0.0019 17.2 48.4 0.036 13.0 6.9 4.0 1 1 0 3 3 3 2 Spc7 kinetochore protein Shugoshin_N PF07558.11 EFO61923.1 - 0.0021 17.9 4.6 0.33 10.9 0.1 4.3 4 0 0 4 4 4 1 Shugoshin N-terminal coiled-coil region DnaB_C PF03796.15 EFO61923.1 - 0.0024 17.2 2.9 0.0024 17.2 2.9 2.8 2 1 0 3 3 3 1 DnaB-like helicase C terminal domain GAS PF13851.6 EFO61923.1 - 0.0055 16.1 46.0 0.0081 15.5 4.1 4.6 1 1 2 4 4 4 2 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 EFO61923.1 - 0.0055 16.9 55.0 0.19 12.0 18.0 4.3 1 1 1 3 3 3 1 Autophagy protein 16 (ATG16) MAD PF05557.13 EFO61923.1 - 0.006 15.0 42.7 0.088 11.2 21.0 2.7 1 1 2 3 3 3 3 Mitotic checkpoint protein CENP-F_leu_zip PF10473.9 EFO61923.1 - 0.016 15.2 48.7 0.56 10.2 13.3 5.6 2 2 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EzrA PF06160.12 EFO61923.1 - 0.027 12.7 36.1 0.037 12.2 8.3 3.2 2 1 0 3 3 3 0 Septation ring formation regulator, EzrA NPV_P10 PF05531.12 EFO61923.1 - 0.027 14.9 17.0 3.4 8.2 0.2 6.9 2 2 3 6 6 6 0 Nucleopolyhedrovirus P10 protein Lebercilin PF15619.6 EFO61923.1 - 0.036 13.7 46.2 0.078 12.6 2.2 6.0 2 2 2 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease WD40_alt PF14077.6 EFO61923.1 - 0.04 13.8 5.9 0.091 12.6 0.0 3.9 3 1 1 4 4 4 0 Alternative WD40 repeat motif SHE3 PF17078.5 EFO61923.1 - 0.1 12.3 37.9 0.063 13.0 13.1 4.5 1 1 2 3 3 2 0 SWI5-dependent HO expression protein 3 FtsH_ext PF06480.15 EFO61923.1 - 0.11 12.9 0.0 0.27 11.6 0.0 1.7 1 0 0 1 1 1 0 FtsH Extracellular TMF_TATA_bd PF12325.8 EFO61923.1 - 0.17 12.1 41.6 0.87 9.8 6.4 5.6 2 2 1 4 4 4 0 TATA element modulatory factor 1 TATA binding YabA PF06156.13 EFO61923.1 - 0.2 12.3 28.9 6.2 7.5 2.6 5.7 2 2 3 5 5 5 0 Initiation control protein YabA DUF4407 PF14362.6 EFO61923.1 - 0.3 10.4 43.9 0.1 12.0 7.7 3.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 EFO61923.1 - 0.3 11.1 56.3 0.9 9.6 6.9 5.4 3 2 2 5 5 5 0 TPR/MLP1/MLP2-like protein Pox_A_type_inc PF04508.12 EFO61923.1 - 0.38 10.7 3.9 56 3.8 0.1 4.4 4 0 0 4 4 3 0 Viral A-type inclusion protein repeat CEP63 PF17045.5 EFO61923.1 - 0.53 10.1 37.4 0.018 14.9 18.7 2.3 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa DUF5082 PF16888.5 EFO61923.1 - 0.62 10.4 34.8 2 8.7 6.9 5.7 2 2 2 4 4 4 0 Domain of unknown function (DUF5082) IFT57 PF10498.9 EFO61923.1 - 0.73 8.7 33.1 0.14 11.1 2.7 3.3 2 1 1 3 3 3 0 Intra-flagellar transport protein 57 BLOC1_2 PF10046.9 EFO61923.1 - 0.74 10.2 34.3 4.4 7.7 5.1 5.3 4 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 EFO61923.1 - 1.4 9.0 30.4 0.027 14.5 4.1 4.5 3 2 1 4 4 4 0 Laminin Domain II MscS_porin PF12795.7 EFO61923.1 - 1.5 8.3 58.7 5.2 6.5 17.2 4.7 1 1 3 4 4 4 0 Mechanosensitive ion channel porin domain TolA_bind_tri PF16331.5 EFO61923.1 - 2.2 8.4 34.0 0.26 11.4 0.3 7.0 4 3 3 7 7 7 0 TolA binding protein trimerisation ADIP PF11559.8 EFO61923.1 - 2.3 8.3 51.3 0.44 10.6 3.8 6.6 2 2 5 7 7 7 0 Afadin- and alpha -actinin-Binding Fez1 PF06818.15 EFO61923.1 - 2.4 8.6 42.3 4.3 7.7 5.9 3.4 1 1 2 3 3 3 0 Fez1 Tropomyosin_1 PF12718.7 EFO61923.1 - 2.6 8.2 43.2 0.12 12.6 2.8 4.4 2 2 2 4 4 3 0 Tropomyosin like Tropomyosin PF00261.20 EFO61923.1 - 3.4 7.0 45.8 0.014 14.8 4.6 4.6 2 2 2 4 4 4 0 Tropomyosin APG6_N PF17675.1 EFO61923.1 - 3.7 8.1 59.9 5.1 7.6 16.6 5.1 1 1 4 5 5 5 0 Apg6 coiled-coil region Sec34 PF04136.15 EFO61923.1 - 7.5 6.4 24.7 0.56 10.1 0.2 4.6 3 3 1 4 4 4 0 Sec34-like family DUF3450 PF11932.8 EFO61923.1 - 9.8 5.4 43.8 0.24 10.7 1.5 5.1 3 3 3 6 6 6 0 Protein of unknown function (DUF3450) Ank_2 PF12796.7 EFO61924.1 - 4.7e-18 65.6 0.1 5.3e-10 39.8 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61924.1 - 1.2e-15 57.3 2.1 7.8e-07 29.3 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61924.1 - 5.5e-15 55.5 0.2 8.8e-08 32.6 0.0 3.0 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61924.1 - 8.3e-11 41.1 0.7 0.091 13.4 0.1 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 EFO61924.1 - 2e-10 40.6 0.7 0.015 15.7 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat TMF_DNA_bd PF12329.8 EFO61924.1 - 0.032 14.2 5.7 0.82 9.7 0.8 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Lebercilin PF15619.6 EFO61924.1 - 0.051 13.2 4.9 0.77 9.4 0.9 2.3 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease ZapB PF06005.12 EFO61924.1 - 0.055 13.9 5.8 0.61 10.6 0.2 2.6 2 0 0 2 2 2 0 Cell division protein ZapB bZIP_1 PF00170.21 EFO61924.1 - 0.066 13.3 7.2 2.4 8.3 0.7 3.2 2 1 1 3 3 3 0 bZIP transcription factor DUF3848 PF12959.7 EFO61924.1 - 0.14 12.2 1.8 0.89 9.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3848) bZIP_2 PF07716.15 EFO61924.1 - 0.35 11.0 7.2 8.9 6.5 0.2 3.3 2 1 1 3 3 3 0 Basic region leucine zipper DivIC PF04977.15 EFO61924.1 - 0.38 10.6 3.3 9.3 6.1 0.4 2.6 2 0 0 2 2 2 0 Septum formation initiator Shugoshin_N PF07558.11 EFO61924.1 - 0.5 10.3 5.0 0.35 10.8 0.5 2.8 2 1 1 3 3 3 0 Shugoshin N-terminal coiled-coil region NYD-SP28_assoc PF14775.6 EFO61924.1 - 0.79 9.9 7.0 3.6 7.8 0.2 3.1 2 1 1 3 3 3 0 Sperm tail C-terminal domain BRE1 PF08647.11 EFO61924.1 - 1.6 8.8 7.5 0.59 10.2 3.5 2.1 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase PRKG1_interact PF15898.5 EFO61924.1 - 5.6 7.9 9.1 45 5.0 8.0 2.4 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain His_Phos_1 PF00300.22 EFO61926.1 - 3.8e-43 147.4 0.0 4.3e-43 147.3 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Pkinase PF00069.25 EFO61927.1 - 7.5e-28 97.6 0.0 1.4e-19 70.5 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61927.1 - 9.4e-10 38.2 0.0 0.00014 21.3 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase PAN_4 PF14295.6 EFO61927.1 - 4.5 7.2 8.7 5.1 7.1 4.5 2.7 2 0 0 2 2 2 0 PAN domain SlyX PF04102.12 EFO61928.1 - 0.008 16.8 6.6 0.008 16.8 6.6 2.0 2 0 0 2 2 2 1 SlyX AAA_23 PF13476.6 EFO61928.1 - 0.0096 16.4 10.5 0.012 16.2 10.5 1.2 1 0 0 1 1 1 1 AAA domain Sugarporin_N PF11471.8 EFO61928.1 - 0.023 14.6 5.7 0.044 13.8 5.7 1.4 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension FliJ PF02050.16 EFO61928.1 - 0.037 14.3 8.8 0.033 14.4 7.1 1.7 2 0 0 2 2 2 0 Flagellar FliJ protein Herpes_UL6 PF01763.16 EFO61928.1 - 0.052 12.1 6.1 0.062 11.8 6.1 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like Laminin_II PF06009.12 EFO61928.1 - 0.057 13.4 8.8 0.21 11.6 5.5 2.3 2 0 0 2 2 2 0 Laminin Domain II Exonuc_VII_L PF02601.15 EFO61928.1 - 0.065 12.8 3.7 0.068 12.7 3.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit TMPIT PF07851.13 EFO61928.1 - 0.19 10.9 4.5 0.25 10.5 4.5 1.3 1 0 0 1 1 1 0 TMPIT-like protein FlaC_arch PF05377.11 EFO61928.1 - 0.2 12.1 10.8 2.1 8.8 1.3 3.5 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Csm1_N PF18504.1 EFO61928.1 - 0.33 11.3 13.3 0.17 12.2 10.4 2.0 2 0 0 2 2 1 0 Csm1 N-terminal domain Cauli_AT PF03233.13 EFO61928.1 - 0.98 9.3 11.6 0.27 11.1 7.8 1.7 1 1 1 2 2 2 0 Aphid transmission protein NPV_P10 PF05531.12 EFO61928.1 - 1.1 9.7 6.0 1.5 9.3 3.2 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 EFO61928.1 - 1.8 8.9 4.3 4 7.8 2.2 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 EFO61928.1 - 2 8.5 11.8 4.7 7.3 3.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FAM76 PF16046.5 EFO61928.1 - 2.3 7.5 10.4 2.6 7.3 10.4 1.2 1 0 0 1 1 1 0 FAM76 protein UPF0242 PF06785.11 EFO61928.1 - 2.3 8.3 15.9 3.1 7.8 15.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Fzo_mitofusin PF04799.13 EFO61928.1 - 2.7 7.5 8.4 0.83 9.2 5.4 1.6 2 0 0 2 2 2 0 fzo-like conserved region DUF16 PF01519.16 EFO61928.1 - 2.9 8.4 14.5 11 6.5 13.0 2.5 1 1 1 2 2 2 0 Protein of unknown function DUF16 Fib_alpha PF08702.10 EFO61928.1 - 4.1 7.6 14.8 0.84 9.8 2.8 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family XhlA PF10779.9 EFO61928.1 - 4.6 7.5 12.8 0.31 11.3 5.6 2.6 2 1 0 2 2 2 0 Haemolysin XhlA ISG65-75 PF11727.8 EFO61928.1 - 5.5 6.1 10.7 1.9 7.6 8.0 1.7 1 1 1 2 2 2 0 Invariant surface glycoprotein Matrilin_ccoil PF10393.9 EFO61928.1 - 5.8 6.8 11.1 17 5.4 3.4 3.5 3 1 1 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin Ank_2 PF12796.7 EFO61931.1 - 7.8e-34 116.1 11.6 1.4e-12 48.0 0.1 3.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61931.1 - 9.4e-17 60.9 5.4 9.4e-07 29.0 0.0 5.1 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61931.1 - 2.5e-16 58.1 3.2 0.0074 16.7 0.0 5.6 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 EFO61931.1 - 2.3e-15 56.2 3.7 0.014 15.8 0.0 5.4 5 1 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 EFO61931.1 - 1.6e-12 47.7 2.5 1.5e-05 25.5 0.1 3.9 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFO61932.1 - 9.1e-16 58.2 1.2 6.2e-07 29.9 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61932.1 - 1e-08 35.2 1.6 0.056 13.8 0.0 4.0 3 1 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61932.1 - 1.8e-07 30.9 0.7 2.2 9.1 0.0 5.0 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 EFO61932.1 - 5.8e-06 26.5 1.9 3.3 8.3 0.0 4.8 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.6 EFO61932.1 - 0.00025 21.5 0.6 0.44 11.2 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Zn-ribbon_8 PF09723.10 EFO61932.1 - 0.071 13.2 0.3 0.14 12.3 0.3 1.5 1 0 0 1 1 1 0 Zinc ribbon domain AAT PF03417.16 EFO61932.1 - 0.37 10.4 3.8 0.22 11.2 0.3 2.1 2 1 0 2 2 2 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Ank_2 PF12796.7 EFO61933.1 - 6.2e-55 183.7 15.6 6.5e-13 49.1 0.1 5.8 2 2 6 8 8 8 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61933.1 - 1.7e-31 107.8 9.0 0.00089 19.5 0.2 8.1 3 2 5 8 8 8 8 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61933.1 - 5.6e-25 87.4 4.4 4.1e-05 24.0 0.2 8.0 6 2 2 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61933.1 - 1.6e-16 58.7 7.2 0.15 12.7 0.0 9.3 8 1 1 9 9 9 5 Ankyrin repeat Ank PF00023.30 EFO61933.1 - 3.8e-13 49.2 16.5 0.69 10.5 0.1 9.4 9 1 0 9 9 9 5 Ankyrin repeat Ank_2 PF12796.7 EFO61934.1 - 7.2e-46 154.7 14.2 4.8e-10 39.9 0.4 5.1 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO61934.1 - 1.1e-20 71.5 6.8 0.15 12.7 0.0 8.6 8 0 0 8 8 8 7 Ankyrin repeat Ank PF00023.30 EFO61934.1 - 1.2e-19 69.7 5.7 0.017 15.5 0.0 8.6 7 1 1 8 8 8 5 Ankyrin repeat Ank_5 PF13857.6 EFO61934.1 - 5.7e-19 67.9 6.9 0.008 16.5 0.0 7.2 4 3 3 7 7 7 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61934.1 - 2.3e-14 53.5 8.2 0.019 15.6 0.0 8.1 6 2 3 9 9 9 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFO61935.1 - 2.8e-48 162.4 8.6 6.4e-15 55.5 0.4 4.8 3 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank PF00023.30 EFO61935.1 - 1.2e-27 95.1 4.9 0.0001 22.6 0.0 8.8 8 1 1 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 EFO61935.1 - 1.4e-27 95.3 8.9 3.7e-05 23.9 0.1 8.0 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61935.1 - 3.9e-26 88.2 7.9 0.084 13.5 0.0 9.6 9 0 0 9 9 9 7 Ankyrin repeat Ank_4 PF13637.6 EFO61935.1 - 3.7e-23 81.6 3.3 9.5e-07 29.3 0.2 6.8 5 2 1 6 6 6 6 Ankyrin repeats (many copies) Adeno_PVIII PF01310.18 EFO61935.1 - 0.99 9.0 6.0 0.58 9.7 0.1 2.4 2 0 0 2 2 2 0 Adenovirus hexon associated protein, protein VIII DUF4592 PF15262.6 EFO61936.1 - 0.076 13.7 1.5 0.19 12.4 0.1 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4592) RNA_pol_Rpb2_6 PF00562.28 EFO61937.1 - 1.6e-107 360.0 0.0 4.9e-107 358.4 0.0 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_3 PF04565.16 EFO61937.1 - 6.6e-23 80.7 0.0 1.8e-22 79.3 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 EFO61937.1 - 2.6e-19 69.4 1.4 5e-19 68.5 0.5 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_1 PF04563.15 EFO61937.1 - 1e-18 67.6 0.0 1e-18 67.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpa2_4 PF06883.12 EFO61937.1 - 7.2e-10 38.7 0.0 1.4e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.14 EFO61937.1 - 0.00018 21.2 0.1 0.00045 19.9 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 EFO61937.1 - 0.0022 18.3 0.0 0.0057 16.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 NESP55 PF06390.12 EFO61941.1 - 0.0053 16.4 0.2 0.0053 16.4 0.2 2.1 2 0 0 2 2 2 1 Neuroendocrine-specific golgi protein P55 (NESP55) VSP PF03302.13 EFO61942.1 - 1.4e-80 271.1 445.2 2.7e-25 89.1 50.9 16.8 1 1 14 16 16 16 14 Giardia variant-specific surface protein TPR_12 PF13424.6 EFO61943.1 - 2.3e-33 114.3 19.4 2.5e-10 40.5 0.1 9.5 5 2 5 10 10 10 5 Tetratricopeptide repeat TPR_10 PF13374.6 EFO61943.1 - 1.1e-20 72.8 4.0 4.2e-05 23.3 0.0 7.3 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_1 PF00515.28 EFO61943.1 - 3.9e-12 45.4 2.9 0.0026 17.5 0.0 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFO61943.1 - 9.6e-09 35.3 12.0 3.2 8.8 1.0 9.1 9 1 1 10 10 9 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFO61943.1 - 1.1e-08 34.5 18.8 0.025 14.7 0.0 8.5 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EFO61943.1 - 5.1e-07 29.4 7.9 0.0018 17.7 0.1 3.4 2 1 0 2 2 2 2 MalT-like TPR region TPR_7 PF13176.6 EFO61943.1 - 2.9e-06 26.9 3.7 1.2 9.3 0.0 7.1 8 1 0 8 8 8 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFO61943.1 - 5.2e-06 26.3 12.1 1.4 9.3 0.0 7.7 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_5 PF12688.7 EFO61943.1 - 2e-05 24.8 4.8 0.00019 21.7 0.3 3.5 3 1 0 3 3 3 1 Tetratrico peptide repeat TPR_11 PF13414.6 EFO61943.1 - 0.00084 19.0 1.3 0.7 9.6 0.0 4.3 4 0 0 4 4 4 1 TPR repeat TPR_19 PF14559.6 EFO61943.1 - 0.002 18.6 16.5 0.17 12.4 1.2 6.4 6 2 1 7 7 7 1 Tetratricopeptide repeat TPR_4 PF07721.14 EFO61943.1 - 0.043 14.4 3.9 1.2e+02 3.8 0.0 5.8 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_21 PF09976.9 EFO61943.1 - 0.13 12.0 5.7 0.27 10.9 0.0 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain TPR_16 PF13432.6 EFO61943.1 - 0.37 11.5 18.7 13 6.5 0.0 6.6 6 2 0 6 6 5 0 Tetratricopeptide repeat Pkinase PF00069.25 EFO61944.1 - 8.7e-50 169.5 0.0 1.1e-49 169.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61944.1 - 2e-26 92.8 0.0 3.1e-26 92.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFO61944.1 - 0.073 12.4 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF603 PF04645.12 EFO61944.1 - 0.087 12.5 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF603 23ISL PF16620.5 EFO61946.1 - 0.11 12.6 5.8 0.22 11.7 5.8 1.5 1 0 0 1 1 1 0 Unstructured linker between I-set domains 2 and 3 on MYLCK Abi_C PF14355.6 EFO61947.1 - 0.11 12.6 0.3 0.39 10.9 0.2 1.9 2 0 0 2 2 2 0 Abortive infection C-terminus POR_N PF01855.19 EFO61948.1 - 2.6e-69 233.5 3.3 4.3e-69 232.8 3.3 1.3 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg POR PF01558.18 EFO61948.1 - 4e-22 79.1 0.0 9.2e-22 78.0 0.0 1.6 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase EKR PF10371.9 EFO61948.1 - 1.3e-15 56.9 0.7 3.5e-15 55.5 0.1 2.1 2 0 0 2 2 1 1 Domain of unknown function PFOR_II PF17147.4 EFO61948.1 - 1.2e-11 44.8 0.1 3.7e-11 43.2 0.1 1.9 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Fer4_7 PF12838.7 EFO61948.1 - 1.3e-08 35.2 6.1 1.3e-08 35.2 6.1 2.0 2 0 0 2 2 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 EFO61948.1 - 1.4e-07 32.3 8.8 1.5e-07 32.2 5.6 2.7 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain TPP_enzyme_C PF02775.21 EFO61948.1 - 5.3e-07 29.5 0.0 1.5e-06 28.1 0.0 1.8 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Fer4_6 PF12837.7 EFO61948.1 - 1.2e-06 28.3 2.2 1.2e-06 28.3 2.2 3.2 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_17 PF13534.6 EFO61948.1 - 2.2e-06 28.1 5.0 0.028 15.0 1.0 2.7 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.27 EFO61948.1 - 2.8e-06 26.9 18.2 3.7e-05 23.3 1.1 3.0 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_10 PF13237.6 EFO61948.1 - 1.3e-05 25.2 11.9 0.00029 20.9 11.4 2.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EFO61948.1 - 1.8e-05 24.8 14.0 7.1e-05 22.9 10.9 2.9 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_21 PF14697.6 EFO61948.1 - 2.1e-05 24.6 13.7 0.0018 18.4 13.7 2.9 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 EFO61948.1 - 5.1e-05 23.1 17.5 0.0095 16.0 3.2 3.3 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_18 PF13746.6 EFO61948.1 - 7.1e-05 23.0 2.5 0.18 12.0 0.3 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 EFO61948.1 - 8.4e-05 22.9 7.4 8.4e-05 22.9 7.4 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 EFO61948.1 - 0.03 14.8 1.3 0.03 14.8 1.3 3.6 4 0 0 4 4 3 0 4Fe-4S binding domain Fer4_13 PF13370.6 EFO61948.1 - 0.092 13.3 10.9 2.1 8.9 4.0 2.9 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_15 PF13459.6 EFO61948.1 - 1.4 9.7 7.1 12 6.7 0.3 2.7 2 0 0 2 2 2 0 4Fe-4S single cluster domain Fer4_20 PF14691.6 EFO61948.1 - 1.9 8.3 8.1 7.5 6.4 0.3 3.0 3 0 0 3 3 3 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster HTH_Crp_2 PF13545.6 EFO61949.1 - 0.0074 16.2 0.1 0.014 15.3 0.1 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Rrf2 PF02082.20 EFO61949.1 - 0.077 13.4 0.1 0.46 10.9 0.0 2.0 2 0 0 2 2 2 0 Transcriptional regulator Sec23_trunk PF04811.15 EFO61950.1 - 3.1e-08 33.5 0.0 6e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.15 EFO61950.1 - 6.3e-07 29.3 4.6 1.1e-06 28.6 3.8 2.0 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 EFO61950.1 - 0.00052 20.7 0.3 0.0011 19.7 0.3 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Helicase_C_3 PF13625.6 EFO61950.1 - 0.049 13.8 0.0 0.24 11.6 0.0 2.1 2 0 0 2 2 2 0 Helicase conserved C-terminal domain DUF1405 PF07187.11 EFO61951.1 - 0.03 14.3 2.1 0.074 13.1 2.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1405) Fumarate_red_C PF02300.17 EFO61951.1 - 0.59 10.2 5.3 2.3 8.3 0.2 2.7 1 1 1 2 2 2 0 Fumarate reductase subunit C Sdh_cyt PF01127.22 EFO61951.1 - 1.8 8.6 13.6 0.59 10.2 1.6 2.7 2 2 0 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Pkinase PF00069.25 EFO61953.1 - 1.7e-56 191.6 0.0 2.4e-56 191.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61953.1 - 5.1e-33 114.4 0.0 7.3e-33 113.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO61953.1 - 3.3e-23 82.1 0.2 5.8e-13 49.2 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61953.1 - 1.2e-14 54.1 1.6 3.8e-05 23.9 0.1 4.5 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61953.1 - 1.1e-13 51.3 0.5 5.7e-06 26.8 0.1 3.7 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO61953.1 - 2.1e-13 50.1 3.9 0.023 15.1 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EFO61953.1 - 6.5e-12 44.5 0.3 0.044 14.3 0.1 5.2 5 0 0 5 5 5 3 Ankyrin repeat Haspin_kinase PF12330.8 EFO61953.1 - 0.052 12.5 0.4 0.1 11.6 0.0 1.6 2 0 0 2 2 2 0 Haspin like kinase domain Kinase-like PF14531.6 EFO61953.1 - 0.15 11.3 0.0 0.52 9.6 0.0 1.9 2 0 0 2 2 2 0 Kinase-like Ank_2 PF12796.7 EFO61954.1 - 3.8e-19 69.0 1.7 7.3e-11 42.5 0.1 2.7 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61954.1 - 1.3e-11 44.5 7.4 0.0076 16.6 0.0 4.6 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61954.1 - 9.1e-11 41.0 2.0 0.0057 17.1 0.0 4.8 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EFO61954.1 - 1e-06 28.9 4.1 0.0029 18.0 0.0 3.7 3 1 1 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EFO61954.1 - 1.2e-06 28.9 1.0 0.058 14.0 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) SlyX PF04102.12 EFO61954.1 - 0.14 12.8 2.8 0.87 10.3 0.1 3.0 3 0 0 3 3 3 0 SlyX Ank_2 PF12796.7 EFO61956.1 - 3.5e-73 242.2 47.0 3.6e-11 43.5 3.2 10.4 4 2 6 10 10 10 10 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61956.1 - 2.9e-38 129.4 35.1 0.0012 19.1 0.1 15.8 9 3 8 17 17 17 14 Ankyrin repeats (many copies) Ank PF00023.30 EFO61956.1 - 2.5e-37 125.7 30.1 0.0018 18.6 0.1 17.3 15 4 2 17 17 17 9 Ankyrin repeat Ank_3 PF13606.6 EFO61956.1 - 1.5e-33 111.1 30.2 0.017 15.6 0.0 17.7 18 0 0 18 18 18 11 Ankyrin repeat Ank_4 PF13637.6 EFO61956.1 - 6.4e-27 93.6 28.4 3.8e-05 24.2 0.3 12.9 10 2 3 13 13 13 7 Ankyrin repeats (many copies) mono-CXXC PF15626.6 EFO61956.1 - 0.52 10.7 2.6 1.3 9.5 2.6 1.6 1 0 0 1 1 1 0 single CXXC unit SRP-alpha_N PF04086.13 EFO61956.1 - 2.1 8.2 5.9 3.8 7.4 5.9 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Tmemb_40 PF10160.9 EFO61957.1 - 0.2 11.1 2.7 0.45 9.9 0.4 2.3 2 0 0 2 2 2 0 Predicted membrane protein HAD_2 PF13419.6 EFO61958.1 - 0.00035 20.7 0.0 0.00093 19.3 0.0 1.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFO61958.1 - 0.001 19.4 0.0 0.011 16.1 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase NIF PF03031.18 EFO61958.1 - 0.17 11.7 0.0 0.57 9.9 0.0 1.8 2 0 0 2 2 2 0 NLI interacting factor-like phosphatase VSP PF03302.13 EFO61959.1 - 1e-65 222.2 165.3 2.3e-27 95.9 23.3 6.9 1 1 7 8 8 8 6 Giardia variant-specific surface protein Ephrin_rec_like PF07699.13 EFO61959.1 - 0.0053 16.5 1.7 0.0053 16.5 1.7 11.7 10 4 3 13 13 13 4 Putative ephrin-receptor like VSP PF03302.13 EFO61960.1 - 4.4e-45 154.2 181.6 6.7e-32 110.8 63.3 7.2 1 1 5 6 6 6 6 Giardia variant-specific surface protein TauE PF01925.19 EFO61961.1 - 2.7e-09 37.0 23.1 2.1e-06 27.6 3.0 2.5 2 1 0 2 2 2 2 Sulfite exporter TauE/SafE DNA_topoisoIV PF00521.20 EFO61962.1 - 1.5e-93 314.0 4.2 7.3e-77 259.1 0.0 3.3 3 1 1 4 4 4 2 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EFO61962.1 - 3.3e-38 130.8 1.0 1.2e-37 129.0 1.0 2.1 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EFO61962.1 - 1.7e-18 66.7 0.0 5.2e-18 65.1 0.0 1.8 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.22 EFO61962.1 - 8.3e-08 32.4 0.1 5.4e-07 29.8 0.0 2.4 2 0 0 2 2 2 1 Toprim domain NS3_envE PF02723.14 EFO61963.1 - 0.11 12.6 7.4 0.12 12.5 7.4 1.2 1 0 0 1 1 1 0 Non-structural protein NS3/Small envelope protein E Prominin PF05478.11 EFO61963.1 - 6.5 4.6 8.0 6.1 4.7 8.0 1.1 1 0 0 1 1 1 0 Prominin Mob1_phocein PF03637.17 EFO61964.1 - 0.08 13.0 0.0 0.08 13.0 0.0 1.2 1 0 0 1 1 1 0 Mob1/phocein family MatE PF01554.18 EFO61965.1 - 2.1e-07 30.8 21.8 0.00048 19.8 4.7 2.9 2 1 0 2 2 2 2 MatE DUF3082 PF11282.8 EFO61965.1 - 0.1 12.9 8.7 1.2 9.4 8.7 2.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3082) AlaE PF06610.13 EFO61965.1 - 0.3 11.1 4.0 3.1 7.8 0.2 2.9 1 1 1 2 2 2 0 L-alanine exporter OTU PF02338.19 EFO61966.1 - 3.7e-08 33.9 0.0 1.9e-07 31.6 0.0 2.1 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EFO61966.1 - 0.011 15.2 0.0 0.022 14.2 0.0 1.5 1 0 0 1 1 1 0 Peptidase C65 Otubain Pet100 PF09803.9 EFO61966.1 - 0.5 10.9 2.5 0.4 11.2 0.3 2.0 2 1 0 2 2 2 0 Pet100 WD40 PF00400.32 EFO61968.1 - 3.5e-09 37.1 9.4 0.00098 19.9 0.1 6.5 7 0 0 7 7 7 3 WD domain, G-beta repeat Nup160 PF11715.8 EFO61968.1 - 0.13 10.8 0.0 0.42 9.2 0.0 1.7 2 0 0 2 2 2 0 Nucleoporin Nup120/160 PQQ_3 PF13570.6 EFO61968.1 - 0.2 12.2 5.0 19 5.9 0.0 4.3 5 0 0 5 5 5 0 PQQ-like domain EFhand_Ca_insen PF08726.10 EFO61969.1 - 0.011 15.8 0.0 0.87 9.7 0.0 2.6 2 1 0 2 2 2 0 Ca2+ insensitive EF hand Lipase_GDSL_2 PF13472.6 EFO61970.1 - 3.9e-16 60.0 0.3 4.7e-16 59.7 0.3 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFO61970.1 - 9.4e-07 29.0 0.1 8.6e-06 25.9 0.1 1.9 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Pkinase PF00069.25 EFO61972.1 - 1.5e-33 116.3 0.0 6.2e-33 114.3 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO61972.1 - 1.4e-14 54.0 0.0 2.2e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase MEKHLA PF08670.11 EFO61972.1 - 0.14 12.0 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 MEKHLA domain Ras PF00071.22 EFO61973.1 - 3.9e-31 107.8 0.0 1.2e-18 67.2 0.0 2.3 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFO61973.1 - 4.3e-22 78.6 0.0 6.3e-11 42.6 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFO61973.1 - 1e-08 34.8 0.0 0.00013 21.5 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFO61973.1 - 0.01 15.2 0.0 1.3 8.3 0.0 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFO61973.1 - 0.014 15.5 0.0 0.09 12.9 0.0 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase SRPRB PF09439.10 EFO61973.1 - 0.11 11.9 1.4 0.41 10.1 0.0 2.3 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit FoP_duplication PF13865.6 EFO61974.1 - 0.1 13.2 0.2 0.23 12.0 0.2 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 ACP53EA PF06313.11 EFO61976.1 - 0.1 12.8 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Drosophila ACP53EA protein Peptidase_C39_2 PF13529.6 EFO61977.1 - 0.23 12.0 1.8 27 5.3 0.1 2.7 2 0 0 2 2 2 0 Peptidase_C39 like family PseudoU_synth_1 PF01416.20 EFO61978.1 - 3.9e-16 59.4 0.0 6.9e-15 55.4 0.0 2.4 2 0 0 2 2 2 1 tRNA pseudouridine synthase LisH PF08513.11 EFO61979.1 - 2.8e-09 36.6 0.5 5.8e-09 35.6 0.5 1.6 1 0 0 1 1 1 1 LisH Ank_2 PF12796.7 EFO61980.1 - 3.2e-74 245.5 21.9 1.1e-12 48.3 0.0 8.3 3 1 5 8 8 8 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61980.1 - 3.5e-40 135.5 26.3 0.00031 21.0 0.0 13.6 3 3 11 14 14 14 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO61980.1 - 6.7e-37 121.3 11.5 0.041 14.4 0.0 14.6 14 0 0 14 14 14 10 Ankyrin repeat Ank PF00023.30 EFO61980.1 - 3.2e-32 109.5 3.1 0.11 13.0 0.0 13.6 14 0 0 14 14 14 9 Ankyrin repeat Ank_4 PF13637.6 EFO61980.1 - 1.5e-31 108.4 15.5 5.6e-05 23.6 0.1 12.8 6 5 7 13 13 13 11 Ankyrin repeats (many copies) DNA_pol3_tau_5 PF12170.8 EFO61982.1 - 0.0026 17.8 1.3 0.007 16.4 1.3 1.7 1 0 0 1 1 1 1 DNA polymerase III tau subunit V interacting with alpha Ank_2 PF12796.7 EFO61983.1 - 3.8e-49 165.2 28.2 3.3e-11 43.6 1.0 7.2 2 2 4 7 7 7 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61983.1 - 3e-30 103.9 21.2 0.0029 17.9 0.0 11.6 5 3 7 12 12 12 11 Ankyrin repeats (many copies) Ank PF00023.30 EFO61983.1 - 4.9e-29 99.5 11.5 0.022 15.2 0.0 12.3 12 0 0 12 12 12 7 Ankyrin repeat Ank_3 PF13606.6 EFO61983.1 - 2.6e-28 94.9 14.5 0.059 14.0 0.0 12.9 13 0 0 13 13 13 7 Ankyrin repeat Ank_4 PF13637.6 EFO61983.1 - 2.1e-25 88.8 18.1 1.6e-06 28.6 0.6 9.9 7 3 1 8 8 8 6 Ankyrin repeats (many copies) Cyclin_N PF00134.23 EFO61983.1 - 0.82 9.4 3.2 15 5.3 0.5 3.7 3 2 0 4 4 4 0 Cyclin, N-terminal domain PAP1 PF08601.10 EFO61983.1 - 3.3 7.4 12.1 5 6.7 12.1 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 VSP PF03302.13 EFO61984.1 - 1.1e-22 80.5 45.6 3.6e-18 65.6 6.0 3.0 1 1 2 3 3 3 3 Giardia variant-specific surface protein BmKX PF09132.10 EFO61984.1 - 5e-16 58.4 17.7 5e-16 58.4 17.7 3.3 3 0 0 3 3 3 2 BmKX Ank_2 PF12796.7 EFO61985.1 - 5.7e-43 145.4 1.3 2.5e-13 50.4 0.0 3.1 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61985.1 - 1.6e-17 63.3 0.5 0.00023 21.4 0.1 4.2 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61985.1 - 8.1e-17 61.4 0.2 1.9e-06 28.3 0.0 3.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO61985.1 - 2.5e-16 59.3 0.1 0.016 15.6 0.0 5.0 4 1 1 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EFO61985.1 - 4e-15 54.4 0.1 0.00086 19.6 0.0 5.1 4 1 1 5 5 5 4 Ankyrin repeat DUF2840 PF11000.8 EFO61986.1 - 0.075 12.8 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2840) Dicty_REP PF05086.12 EFO61987.1 - 0.2 9.6 0.6 0.26 9.2 0.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Ras PF00071.22 EFO61990.1 - 8.1e-56 188.1 0.3 1.1e-55 187.7 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFO61990.1 - 5.7e-35 120.1 0.1 8.8e-35 119.5 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFO61990.1 - 7.9e-17 61.3 0.0 1.1e-16 60.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFO61990.1 - 1.7e-06 27.6 0.0 2.1e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFO61990.1 - 4.3e-06 26.8 0.1 7.5e-06 26.0 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFO61990.1 - 2.7e-05 23.8 0.0 4.4e-05 23.1 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFO61990.1 - 0.00011 22.2 0.6 0.19 11.6 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EFO61990.1 - 0.0012 19.1 0.0 0.0083 16.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EFO61990.1 - 0.012 15.1 0.1 0.018 14.5 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 EFO61990.1 - 0.018 14.5 0.0 0.038 13.4 0.0 1.5 2 0 0 2 2 2 0 Bacterial TniB protein FeoB_N PF02421.18 EFO61990.1 - 0.019 14.5 0.1 0.29 10.7 0.1 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B MCM PF00493.23 EFO61990.1 - 0.059 12.5 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain Spo0M PF07070.11 EFO61991.1 - 0.088 12.3 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 SpoOM protein SRX PF09201.10 EFO61991.1 - 0.19 11.6 0.4 0.38 10.6 0.4 1.4 1 0 0 1 1 1 0 SRX, signal recognition particle receptor alpha subunit WD40 PF00400.32 EFO61993.1 - 1.2e-11 44.9 10.0 0.019 15.8 0.1 6.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO61993.1 - 0.068 13.5 0.0 61 4.0 0.0 4.1 4 1 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFO61993.1 - 0.12 11.3 0.0 3.2 6.6 0.0 3.0 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein ARID PF01388.21 EFO61994.1 - 1.9e-14 54.1 0.0 4.6e-14 52.8 0.0 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain LRR_1 PF00560.33 EFO61995.1 - 9.4e-05 22.5 0.2 4.5 8.2 0.0 4.4 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_6 PF13516.6 EFO61995.1 - 0.0013 18.6 8.4 5 7.4 0.0 6.4 7 0 0 7 7 7 1 Leucine Rich repeat LRR_4 PF12799.7 EFO61995.1 - 0.043 14.2 5.8 2.2 8.8 0.1 3.7 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) Collagen PF01391.18 EFO61995.1 - 0.06 13.1 15.4 0.92 9.3 2.3 2.3 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) Ribosomal_L24e PF01246.20 EFO61996.1 - 2e-31 108.0 4.9 2e-31 108.0 4.9 2.0 2 0 0 2 2 2 1 Ribosomal protein L24e zf-FLZ PF04570.14 EFO61996.1 - 0.068 12.7 3.0 0.14 11.6 3.0 1.5 1 0 0 1 1 1 0 zinc-finger of the FCS-type, C2-C2 DUF2116 PF09889.9 EFO61996.1 - 3.7 7.6 9.7 7.7 6.6 0.5 2.8 3 0 0 3 3 3 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DEAD PF00270.29 EFO61997.1 - 2.5e-08 33.9 0.0 5e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO61997.1 - 1.9e-07 31.4 0.0 5.7e-07 29.9 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HA2 PF04408.23 EFO61997.1 - 5.5e-05 23.4 0.0 0.00011 22.4 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) AAA_22 PF13401.6 EFO61997.1 - 0.0048 17.2 0.0 0.013 15.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain Ank_2 PF12796.7 EFO61999.1 - 2.2e-70 233.3 15.7 8.3e-11 42.3 0.1 8.5 2 2 7 9 9 9 9 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO61999.1 - 9.1e-42 140.6 20.2 0.00014 22.0 0.0 12.2 3 3 8 12 12 12 11 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO61999.1 - 1.2e-35 121.4 8.6 1.8e-05 25.2 0.0 10.0 10 0 0 10 10 10 9 Ankyrin repeats (many copies) Ank PF00023.30 EFO61999.1 - 7.9e-32 108.3 13.7 0.011 16.2 0.0 13.2 12 1 1 13 13 13 9 Ankyrin repeat Ank_3 PF13606.6 EFO61999.1 - 1.2e-31 105.2 15.7 0.061 13.9 0.0 14.5 15 0 0 15 15 15 10 Ankyrin repeat PGI PF00342.19 EFO62000.1 - 1.6e-42 145.7 0.0 9.4e-33 113.5 0.0 3.0 1 1 0 2 2 2 2 Phosphoglucose isomerase Pkinase PF00069.25 EFO62001.1 - 2.8e-53 181.0 0.0 3.3e-53 180.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62001.1 - 1.4e-21 77.0 0.0 4.8e-21 75.2 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO62001.1 - 8.7e-05 22.0 0.0 0.011 15.0 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 EFO62001.1 - 0.0025 17.2 0.1 0.0041 16.5 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family cNMP_binding PF00027.29 EFO62002.1 - 1.2e-32 111.8 0.0 7e-18 64.5 0.0 3.1 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain CNOT1_CAF1_bind PF16415.5 EFO62003.1 - 0.035 13.5 1.3 1.8 7.9 0.2 2.2 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF2740 PF10872.8 EFO62003.1 - 0.036 14.0 0.7 0.1 12.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2740) DEAD PF00270.29 EFO62004.1 - 2.1e-44 151.4 0.0 3.3e-44 150.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO62004.1 - 1.3e-31 109.2 0.4 7.6e-30 103.5 0.1 2.8 2 1 0 3 3 3 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EFO62004.1 - 9.3e-08 31.6 0.0 1.4e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 EFO62004.1 - 5e-06 26.6 0.0 7.9e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EFO62004.1 - 0.061 13.0 0.0 0.2 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain Terminase_6 PF03237.15 EFO62004.1 - 0.12 12.0 0.0 1.3 8.6 0.0 2.1 1 1 0 1 1 1 0 Terminase-like family Pox_P35 PF03213.14 EFO62005.1 - 0.015 14.5 0.1 0.022 14.0 0.1 1.2 1 0 0 1 1 1 0 Poxvirus P35 protein SAS-6_N PF16531.5 EFO62006.1 - 9.1e-20 71.1 0.1 1.3e-19 70.5 0.1 1.2 1 0 0 1 1 1 1 Centriolar protein SAS N-terminal HALZ PF02183.18 EFO62006.1 - 0.039 14.2 0.5 0.095 12.9 0.1 1.9 2 0 0 2 2 2 0 Homeobox associated leucine zipper Pox_VP8_L4R PF04498.12 EFO62006.1 - 0.068 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Poxvirus nucleic acid binding protein VP8/L4R VDE PF07137.11 EFO62006.1 - 0.084 12.4 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 VDE lipocalin domain EF-hand_13 PF17958.1 EFO62007.1 - 3.2e-19 68.5 0.0 9.5e-18 63.8 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 EFO62007.1 - 9.5e-15 54.8 1.6 0.0002 21.8 0.0 4.5 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.32 EFO62007.1 - 7.3e-05 22.0 7.3 0.038 13.6 0.1 3.1 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EFO62007.1 - 0.00015 21.4 1.2 0.24 11.4 0.3 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 EFO62007.1 - 0.0014 18.5 5.4 0.074 12.9 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EFO62007.1 - 0.048 13.2 1.1 2.9 7.6 0.5 2.8 2 0 0 2 2 2 0 EF hand EcpB_C PF18649.1 EFO62007.1 - 0.053 13.5 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 EcpB C-terminal domain RNA_pol_Rpb1_5 PF04998.17 EFO62008.1 - 6.9e-76 255.2 0.2 1.2e-75 254.4 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EFO62008.1 - 1e-47 162.5 0.0 1.5e-44 152.1 0.0 3.4 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EFO62008.1 - 6e-24 84.8 0.0 4.5e-23 81.9 0.0 2.6 3 1 0 3 3 3 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 EFO62008.1 - 1.9e-20 73.4 0.5 9.3e-15 54.7 0.0 3.7 3 0 0 3 3 3 2 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 EFO62008.1 - 9.7e-15 54.4 0.1 9.7e-15 54.4 0.1 2.5 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 GAS PF13851.6 EFO62009.1 - 0.00015 21.1 42.4 0.15 11.4 12.2 4.2 2 1 0 3 3 3 3 Growth-arrest specific micro-tubule binding TPR_MLP1_2 PF07926.12 EFO62009.1 - 0.0079 16.3 55.1 0.021 14.9 18.3 4.2 3 2 1 4 4 4 2 TPR/MLP1/MLP2-like protein bZIP_1 PF00170.21 EFO62009.1 - 0.023 14.8 3.1 0.023 14.8 3.1 5.2 4 2 3 7 7 7 0 bZIP transcription factor Filament PF00038.21 EFO62009.1 - 0.073 12.6 41.4 0.6 9.6 10.0 3.8 1 1 3 4 4 4 0 Intermediate filament protein Fez1 PF06818.15 EFO62009.1 - 2.5 8.5 40.0 0.024 15.1 14.0 3.5 1 1 3 4 4 4 0 Fez1 ERM PF00769.19 EFO62009.1 - 5.2 6.8 47.1 1.7 8.4 16.9 2.8 1 1 1 2 2 2 0 Ezrin/radixin/moesin family MCM PF00493.23 EFO62010.1 - 9.8e-85 283.2 0.0 1.6e-84 282.5 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFO62010.1 - 6.3e-27 93.9 1.3 1.2e-26 93.1 1.3 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFO62010.1 - 2.8e-22 78.9 2.7 2.9e-22 78.9 0.8 2.0 2 0 0 2 2 2 1 MCM AAA-lid domain AAA_5 PF07728.14 EFO62010.1 - 5.2e-11 42.7 0.0 1.5e-10 41.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EFO62010.1 - 7.8e-08 31.9 0.0 1.9e-05 24.1 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EFO62010.1 - 4.3e-06 26.6 0.0 2.8e-05 24.0 0.0 2.4 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 EFO62010.1 - 0.0053 16.9 0.0 0.01 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RPA_C PF08784.11 EFO62010.1 - 0.017 15.8 0.2 0.045 14.4 0.2 1.8 1 0 0 1 1 1 0 Replication protein A C terminal tRNA-synt_1d PF00750.19 EFO62010.1 - 0.049 12.6 0.4 0.6 9.0 0.1 2.1 1 1 1 2 2 2 0 tRNA synthetases class I (R) AAA_16 PF13191.6 EFO62010.1 - 0.086 13.2 0.2 0.45 10.9 0.2 2.3 1 1 0 1 1 1 0 AAA ATPase domain Elf1 PF05129.13 EFO62010.1 - 0.092 12.8 3.9 0.2 11.7 3.9 1.5 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zf-CXXC PF02008.20 EFO62010.1 - 1.5 8.9 4.8 1 9.5 2.9 1.7 1 1 0 1 1 1 0 CXXC zinc finger domain WD40_alt PF14077.6 EFO62011.1 - 0.0043 16.9 1.3 0.017 14.9 0.1 2.7 2 0 0 2 2 2 1 Alternative WD40 repeat motif RTBV_P46 PF06216.11 EFO62011.1 - 0.0059 15.5 0.3 0.016 14.1 0.3 1.6 1 0 0 1 1 1 1 Rice tungro bacilliform virus P46 protein Syntaxin-18_N PF10496.9 EFO62011.1 - 0.052 13.8 2.2 0.15 12.3 0.6 2.6 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus Pox_A_type_inc PF04508.12 EFO62011.1 - 0.069 13.0 3.2 8.2 6.5 0.1 4.7 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat HOOK PF05622.12 EFO62011.1 - 0.3 9.2 53.8 0.18 9.9 39.9 2.7 2 1 0 2 2 2 0 HOOK protein bZIP_1 PF00170.21 EFO62011.1 - 0.34 11.0 0.1 0.34 11.0 0.1 7.6 7 2 2 9 9 9 0 bZIP transcription factor GAS PF13851.6 EFO62011.1 - 0.82 9.0 61.5 0.099 12.0 3.4 5.8 2 1 3 5 5 5 0 Growth-arrest specific micro-tubule binding HALZ PF02183.18 EFO62011.1 - 2.2 8.6 27.0 2.1 8.6 1.3 7.3 7 0 0 7 7 7 0 Homeobox associated leucine zipper Shugoshin_N PF07558.11 EFO62011.1 - 2.6 8.0 14.7 0.23 11.3 0.5 4.9 6 0 0 6 6 6 0 Shugoshin N-terminal coiled-coil region Plasmid_RAQPRD PF09686.10 EFO62011.1 - 4.9 7.4 10.7 3.6 7.9 0.9 3.7 2 1 1 3 3 3 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Pkinase PF00069.25 EFO62012.1 - 1.2e-43 149.4 0.0 1.5e-43 149.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62012.1 - 2.3e-22 79.6 0.0 3.2e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO62012.1 - 6e-06 25.8 0.0 0.00038 19.9 0.0 2.1 2 0 0 2 2 2 2 Kinase-like T2SSF PF00482.23 EFO62013.1 - 0.063 13.2 0.4 16 5.5 0.1 3.5 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F Herp-Cyclin PF09241.10 EFO62013.1 - 0.095 13.4 0.2 1.2 9.8 0.0 2.8 2 0 0 2 2 2 0 Herpesviridae viral cyclin Ank_2 PF12796.7 EFO62014.1 - 5.1e-90 296.2 17.2 9.1e-18 64.6 0.1 8.7 2 2 8 10 10 10 9 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62014.1 - 4.1e-47 157.6 21.3 0.00043 20.5 0.0 14.7 2 2 14 16 16 16 14 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62014.1 - 1.9e-45 147.6 5.6 0.034 14.7 0.0 15.5 16 0 0 16 16 16 11 Ankyrin repeat Ank PF00023.30 EFO62014.1 - 1.5e-44 148.6 13.4 0.0048 17.3 0.0 15.3 16 0 0 16 16 16 12 Ankyrin repeat Ank_4 PF13637.6 EFO62014.1 - 2.6e-40 136.3 11.1 0.00012 22.5 0.1 12.3 9 5 3 12 12 12 9 Ankyrin repeats (many copies) 3HCDH_RFF PF18321.1 EFO62014.1 - 0.04 14.3 0.7 8.2 7.0 0.0 4.8 6 0 0 6 6 6 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain Pkinase PF00069.25 EFO62015.1 - 8e-32 110.6 0.0 1.1e-31 110.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EFO62015.1 - 1.5e-16 60.7 4.4 9.7e-08 32.5 0.3 3.5 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EFO62015.1 - 1.3e-14 54.1 0.0 4.4e-14 52.4 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Ank_3 PF13606.6 EFO62015.1 - 9.6e-08 31.7 2.2 0.092 13.4 0.0 5.3 4 1 1 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 EFO62015.1 - 1.3e-05 25.4 0.8 0.0056 17.0 0.0 3.6 2 2 2 4 4 4 1 Ankyrin repeats (many copies) Ank PF00023.30 EFO62015.1 - 8.5e-05 22.8 0.1 3 8.5 0.0 4.6 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 EFO62015.1 - 0.0073 16.9 0.1 1.9 9.1 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeats (many copies) RFX5_N PF18326.1 EFO62015.1 - 0.12 12.1 0.3 0.31 10.8 0.3 1.6 1 0 0 1 1 1 0 RFX5 N-terminal domain VSP PF03302.13 EFO62016.1 - 7.1e-204 677.1 190.9 1.2e-190 633.5 116.8 3.5 2 1 2 4 4 4 3 Giardia variant-specific surface protein SKG6 PF08693.10 EFO62016.1 - 0.26 10.7 5.0 0.61 9.5 5.0 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Podoplanin PF05808.11 EFO62016.1 - 0.3 11.2 1.4 0.67 10.0 0.1 2.3 2 0 0 2 2 2 0 Podoplanin Bromodomain PF00439.25 EFO62017.1 - 0.00015 21.8 0.3 0.00037 20.5 0.1 1.8 2 0 0 2 2 2 1 Bromodomain AAA_6 PF12774.7 EFO62018.1 - 9.2e-144 478.4 0.0 2.1e-143 477.2 0.0 1.7 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFO62018.1 - 2.1e-106 356.4 11.9 3e-106 355.9 0.3 5.0 4 1 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 EFO62018.1 - 1.3e-77 261.1 0.7 6.5e-76 255.5 0.0 3.3 3 0 0 3 3 3 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 EFO62018.1 - 5.2e-70 235.0 0.5 5.4e-67 225.1 2.5 3.0 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_8 PF12780.7 EFO62018.1 - 1.1e-66 224.9 0.0 2.2e-66 223.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.7 EFO62018.1 - 1e-57 195.7 11.8 3.2e-57 194.1 11.8 1.8 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.7 EFO62018.1 - 1.6e-47 161.3 2.0 4.4e-36 124.1 0.0 4.5 5 0 0 5 5 5 2 P-loop containing dynein motor region Dynein_heavy PF03028.15 EFO62018.1 - 4.5e-37 126.8 0.0 8.7e-36 122.6 0.0 3.1 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 EFO62018.1 - 2.9e-33 115.0 0.0 7.5e-33 113.7 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 EFO62018.1 - 1.3e-14 54.2 0.1 4.3e-14 52.5 0.1 1.9 1 0 0 1 1 1 1 AAA+ lid domain Dynein_AAA_lid PF17852.1 EFO62018.1 - 1.4e-11 44.6 0.0 2.8e-06 27.4 0.0 3.0 2 0 0 2 2 2 2 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 EFO62018.1 - 1.1e-08 35.2 0.0 0.21 11.6 0.0 6.1 5 1 0 5 5 5 2 AAA domain (dynein-related subfamily) AAA PF00004.29 EFO62018.1 - 0.00064 20.2 0.5 0.84 10.1 0.1 4.0 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Borrelia_lipo_1 PF05714.11 EFO62018.1 - 0.089 12.6 1.4 0.45 10.3 1.4 2.2 1 0 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein AAA_18 PF13238.6 EFO62018.1 - 0.091 13.3 0.3 8.6 6.9 0.0 4.0 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 EFO62018.1 - 0.17 12.3 0.0 47 4.4 0.0 3.4 3 0 0 3 3 3 0 RNA helicase Vps62 PF06101.11 EFO62018.1 - 0.19 10.0 0.0 1.6 6.9 0.0 2.0 2 0 0 2 2 2 0 Vacuolar protein sorting-associated protein 62 ABC_tran PF00005.27 EFO62018.1 - 0.95 10.0 4.5 2.4 8.7 0.0 4.0 4 0 0 4 4 2 0 ABC transporter Ribosomal_S14 PF00253.21 EFO62019.1 - 2.2e-09 36.9 3.6 3.6e-09 36.2 3.6 1.3 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e Gb3_synth PF04572.12 EFO62019.1 - 0.054 13.7 0.0 0.072 13.3 0.0 1.2 1 0 0 1 1 1 0 Alpha 1,4-glycosyltransferase conserved region zf-RRN7 PF11781.8 EFO62019.1 - 0.42 10.3 5.9 0.34 10.6 4.1 1.8 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-FPG_IleRS PF06827.14 EFO62019.1 - 0.81 9.6 5.8 4.7 7.2 3.2 2.5 2 1 0 2 2 2 0 Zinc finger found in FPG and IleRS zf-CCHC_2 PF13696.6 EFO62019.1 - 1.6 8.6 5.8 5.1 7.0 0.4 2.6 2 0 0 2 2 2 0 Zinc knuckle Ribosomal_L4 PF00573.22 EFO62020.1 - 1.7e-37 129.0 0.0 2.2e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EFO62020.1 - 1.5e-10 41.0 0.1 3.7e-10 39.7 0.0 1.7 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Pkinase PF00069.25 EFO62021.1 - 6.2e-30 104.4 0.0 8.5e-30 104.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62021.1 - 1.1e-15 57.7 0.0 1.4e-15 57.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO62021.1 - 8.3e-07 28.6 0.0 1.4e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Ank_2 PF12796.7 EFO62022.1 - 1.6e-05 25.4 1.0 0.00058 20.4 0.3 2.8 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) RabGAP-TBC PF00566.18 EFO62024.1 - 1.4e-05 24.9 3.8 0.0077 15.9 0.0 2.8 3 0 0 3 3 3 2 Rab-GTPase-TBC domain DUF2163 PF09931.9 EFO62024.1 - 0.07 13.3 0.0 11 6.2 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2163) Med6 PF04934.14 EFO62026.1 - 4.5e-05 23.2 2.7 0.00021 21.1 2.7 1.8 1 1 0 1 1 1 1 MED6 mediator sub complex component Copine PF07002.16 EFO62027.1 - 2.9e-46 157.7 0.0 3.6e-46 157.4 0.0 1.1 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 EFO62027.1 - 7e-10 39.3 0.0 9.6e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 EFO62027.1 - 0.013 15.7 0.0 0.018 15.3 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain Ank_2 PF12796.7 EFO62028.1 - 1.3e-23 83.4 4.8 1.7e-09 38.1 0.1 6.3 2 2 5 7 7 7 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62028.1 - 5.5e-13 48.9 4.4 5.3e-05 23.4 0.1 6.0 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62028.1 - 3.6e-10 39.2 4.0 0.059 13.9 0.0 6.9 6 0 0 6 6 6 2 Ankyrin repeat Ank_4 PF13637.6 EFO62028.1 - 2e-08 34.6 4.9 0.0011 19.5 0.2 5.7 5 1 0 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO62028.1 - 3.8e-05 23.9 3.9 0.0077 16.6 0.0 5.4 7 0 0 7 7 7 1 Ankyrin repeat VSP PF03302.13 EFO62030.1 - 2.9 6.7 98.3 0.54 9.1 18.3 4.2 1 1 1 3 3 3 0 Giardia variant-specific surface protein VSP PF03302.13 EFO62031.1 - 9.7e-13 47.7 10.3 1.3e-12 47.4 10.3 1.2 1 0 0 1 1 1 1 Giardia variant-specific surface protein Ephrin_rec_like PF07699.13 EFO62031.1 - 0.013 15.3 2.1 0.013 15.3 2.1 3.9 1 1 3 4 4 4 0 Putative ephrin-receptor like PHO4 PF01384.20 EFO62031.1 - 0.088 11.8 0.0 0.1 11.6 0.0 1.1 1 0 0 1 1 1 0 Phosphate transporter family DUF2373 PF10180.9 EFO62032.1 - 1.2e-13 50.7 0.3 1.9e-13 50.0 0.3 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) LRR_4 PF12799.7 EFO62033.1 - 0.00022 21.5 18.3 0.16 12.5 0.2 5.6 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFO62033.1 - 0.042 13.9 4.7 67 3.9 0.0 5.1 4 0 0 4 4 4 0 Leucine Rich repeat Goodbye PF17109.5 EFO62033.1 - 0.42 11.1 1.8 0.96 9.9 0.1 2.6 3 1 1 4 4 4 0 fungal STAND N-terminal Goodbye domain LRR_8 PF13855.6 EFO62033.1 - 0.65 9.8 8.8 9.1 6.1 3.5 3.7 3 1 0 3 3 3 0 Leucine rich repeat Snf7 PF03357.21 EFO62034.1 - 2e-09 37.3 19.3 2.4e-09 37.1 19.3 1.1 1 0 0 1 1 1 1 Snf7 DUF1403 PF07183.11 EFO62034.1 - 0.02 14.5 1.2 0.02 14.5 1.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1403) BBP1_C PF15272.6 EFO62034.1 - 0.045 13.6 3.9 0.062 13.1 3.9 1.2 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal ApoO PF09769.9 EFO62034.1 - 0.08 12.9 0.2 0.17 11.9 0.2 1.5 1 0 0 1 1 1 0 Apolipoprotein O CLZ PF16526.5 EFO62034.1 - 0.13 12.7 12.4 0.26 11.6 1.4 3.1 2 1 2 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels YlqD PF11068.8 EFO62034.1 - 1.8 8.9 11.5 0.35 11.3 5.4 2.3 1 1 1 2 2 2 0 YlqD protein JIP_LZII PF16471.5 EFO62034.1 - 2.7 8.2 14.8 0.48 10.6 3.7 3.3 1 1 2 3 3 3 0 JNK-interacting protein leucine zipper II LRR_8 PF13855.6 EFO62035.1 - 0.0001 22.0 5.5 4.4 7.1 0.0 5.2 5 1 1 6 6 6 2 Leucine rich repeat Trypan_PARP PF05887.11 EFO62035.1 - 0.00056 19.9 3.9 0.0012 18.8 3.9 1.5 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) LRR_4 PF12799.7 EFO62035.1 - 0.0052 17.2 12.8 1.6 9.2 0.4 4.6 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFO62035.1 - 0.18 12.4 10.1 75 4.5 0.0 5.7 5 1 0 5 5 5 0 Leucine Rich Repeat Annexin PF00191.20 EFO62036.1 - 1.3e-11 44.3 0.8 0.024 14.7 0.0 3.6 4 0 0 4 4 4 3 Annexin DUF1122 PF06557.11 EFO62036.1 - 0.044 13.2 0.1 0.07 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1122) Ank_2 PF12796.7 EFO62037.1 - 2.6e-17 63.2 0.4 4.2e-08 33.7 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO62037.1 - 5.2e-10 38.7 0.9 1 10.2 0.0 4.8 3 1 1 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 EFO62037.1 - 4.2e-07 30.4 0.3 0.088 13.4 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62037.1 - 2.3e-06 27.8 0.9 0.55 10.6 0.1 4.2 1 1 3 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO62037.1 - 1.5e-05 25.2 0.4 0.28 11.7 0.0 4.1 3 1 1 4 4 4 2 Ankyrin repeat Lebercilin PF15619.6 EFO62037.1 - 0.0017 18.1 4.0 0.0017 18.1 4.0 5.9 5 2 0 6 6 6 1 Ciliary protein causing Leber congenital amaurosis disease Hrs_helical PF12210.8 EFO62037.1 - 0.058 13.9 12.2 0.1 13.2 1.9 3.5 3 0 0 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate DASH_Dam1 PF08653.10 EFO62037.1 - 3.1 7.6 4.4 13 5.7 0.1 3.5 3 0 0 3 3 3 0 DASH complex subunit Dam1 AAA PF00004.29 EFO62038.1 - 5.9e-35 120.6 0.0 1.3e-34 119.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EFO62038.1 - 9.4e-08 32.0 0.0 2.6e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_2 PF07724.14 EFO62038.1 - 4.8e-06 26.8 0.0 1.1e-05 25.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFO62038.1 - 3.6e-05 24.1 0.6 0.0068 16.7 0.1 2.7 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 EFO62038.1 - 0.00012 21.9 0.0 0.00026 20.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EFO62038.1 - 0.00019 21.5 0.0 0.00083 19.4 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 EFO62038.1 - 0.00024 20.8 0.0 0.0019 17.9 0.0 2.3 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 EFO62038.1 - 0.00038 20.9 0.6 0.0053 17.2 0.1 2.4 1 1 0 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 EFO62038.1 - 0.0012 18.9 0.4 0.68 9.8 0.0 2.4 1 1 1 2 2 2 2 ATPase domain predominantly from Archaea ATPase PF06745.13 EFO62038.1 - 0.0013 18.1 0.2 0.38 10.0 0.0 2.3 1 1 1 2 2 2 2 KaiC AAA_17 PF13207.6 EFO62038.1 - 0.0037 17.7 0.0 0.028 14.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EFO62038.1 - 0.0064 16.1 0.2 0.04 13.5 0.1 2.1 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 EFO62038.1 - 0.0089 15.3 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 EFO62038.1 - 0.011 15.8 0.0 0.039 14.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EFO62038.1 - 0.011 15.5 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 EFO62038.1 - 0.014 15.9 0.0 0.033 14.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFO62038.1 - 0.025 14.8 0.0 0.053 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 EFO62038.1 - 0.033 14.0 0.3 0.47 10.2 0.1 2.2 1 1 1 2 2 2 0 DEAD/DEAH box helicase TsaE PF02367.17 EFO62038.1 - 0.041 13.9 0.0 0.078 13.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 EFO62038.1 - 0.045 13.5 0.0 0.076 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EFO62038.1 - 0.07 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI SIR2 PF02146.17 EFO62040.1 - 5.8e-28 98.0 0.0 4.3e-26 91.9 0.0 2.4 1 1 0 1 1 1 1 Sir2 family Zn-ribbon_8 PF09723.10 EFO62040.1 - 0.045 13.9 0.3 0.095 12.8 0.3 1.5 1 0 0 1 1 1 0 Zinc ribbon domain zf-RING_7 PF02591.15 EFO62040.1 - 0.16 12.1 3.4 0.17 12.1 1.6 2.0 2 0 0 2 2 2 0 C4-type zinc ribbon domain Baculo_PEP_C PF04513.12 EFO62041.1 - 0.0083 16.2 5.1 0.021 14.8 3.4 2.6 1 1 2 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus Ig_J_chain PF15097.6 EFO62041.1 - 0.13 12.2 0.1 0.28 11.1 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin J chain FlgN PF05130.12 EFO62041.1 - 0.18 12.3 0.7 0.55 10.7 0.7 1.8 1 0 0 1 1 1 0 FlgN protein NPV_P10 PF05531.12 EFO62041.1 - 0.9 10.0 3.1 3.5 8.2 0.1 3.2 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein RRM_1 PF00076.22 EFO62042.1 - 3.6e-10 39.5 0.9 4.6e-10 39.2 0.2 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFO62042.1 - 6.5e-07 29.4 0.1 2.8e-06 27.4 0.1 2.1 1 1 0 1 1 1 1 RNA recognition motif TylF PF05711.11 EFO62042.1 - 0.013 14.8 0.0 0.019 14.2 0.0 1.2 1 0 0 1 1 1 0 Macrocin-O-methyltransferase (TylF) Nup35_RRM_2 PF14605.6 EFO62042.1 - 0.038 14.0 0.1 0.11 12.5 0.0 1.8 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Ank_2 PF12796.7 EFO62043.1 - 8.8e-69 228.1 23.5 3.8e-09 37.0 0.2 10.8 2 1 7 10 10 10 9 Ankyrin repeats (3 copies) Ank PF00023.30 EFO62043.1 - 7.4e-35 117.9 24.6 0.0063 16.9 0.0 16.7 16 0 0 16 16 16 11 Ankyrin repeat Ank_5 PF13857.6 EFO62043.1 - 1.7e-34 117.4 30.9 6e-07 29.6 0.1 16.5 7 3 11 18 18 18 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62043.1 - 3.1e-31 103.9 28.8 0.03 14.8 0.0 17.8 19 0 0 19 19 19 8 Ankyrin repeat Ank_4 PF13637.6 EFO62043.1 - 1.5e-30 105.2 19.3 0.0002 21.9 0.4 12.0 7 4 7 14 14 14 10 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO62043.1 - 4.6e-09 36.0 0.0 5.6e-05 22.6 0.0 2.6 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62043.1 - 0.00042 19.7 0.0 0.00098 18.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PPR_3 PF13812.6 EFO62043.1 - 0.23 11.6 0.6 3.1 7.9 0.0 3.0 2 0 0 2 2 2 0 Pentatricopeptide repeat domain WD40 PF00400.32 EFO62044.1 - 2.2e-08 34.6 2.1 0.0017 19.1 0.2 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat TPR_14 PF13428.6 EFO62045.1 - 6.2e-07 29.7 0.4 0.26 12.2 0.4 4.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFO62045.1 - 0.00032 21.1 0.5 4.1 8.0 0.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFO62045.1 - 0.0022 17.7 7.0 0.4 10.6 1.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFO62045.1 - 0.006 16.6 10.0 1.9 8.8 0.7 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFO62045.1 - 0.025 14.9 4.1 7.3 7.0 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFO62045.1 - 0.036 14.7 3.3 1.1 10.0 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Cytochrom_C552 PF02335.15 EFO62045.1 - 0.76 8.6 2.5 0.89 8.4 0.2 2.0 2 0 0 2 2 2 0 Cytochrome c552 Fez1 PF06818.15 EFO62046.1 - 9.2e-05 23.0 85.1 0.042 14.3 14.2 7.1 1 1 4 6 6 6 3 Fez1 TPR_MLP1_2 PF07926.12 EFO62046.1 - 0.0003 20.9 17.2 0.0003 20.9 17.2 9.5 5 4 1 7 7 7 1 TPR/MLP1/MLP2-like protein Atg14 PF10186.9 EFO62046.1 - 0.0012 18.0 7.2 0.0012 18.0 7.2 6.8 1 1 2 5 5 5 1 Vacuolar sorting 38 and autophagy-related subunit 14 APG6_N PF17675.1 EFO62046.1 - 0.0053 17.3 1.3 0.0053 17.3 1.3 9.8 2 2 7 9 9 9 3 Apg6 coiled-coil region ATG16 PF08614.11 EFO62046.1 - 0.01 16.1 114.8 0.033 14.4 13.0 8.8 2 2 4 7 7 7 0 Autophagy protein 16 (ATG16) ADIP PF11559.8 EFO62046.1 - 0.019 15.0 1.9 0.019 15.0 1.9 10.0 5 4 5 10 10 10 0 Afadin- and alpha -actinin-Binding GAS PF13851.6 EFO62046.1 - 0.24 10.7 101.1 0.08 12.3 13.2 9.4 4 3 2 8 8 8 0 Growth-arrest specific micro-tubule binding DUF1729 PF08354.10 EFO62046.1 - 0.24 10.2 2.0 1.3 7.8 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1729) DUF4407 PF14362.6 EFO62046.1 - 1 8.7 65.2 0.078 12.3 7.8 6.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) TMF_TATA_bd PF12325.8 EFO62046.1 - 5.1 7.3 101.2 1.1 9.5 3.4 10.9 3 3 6 10 10 10 0 TATA element modulatory factor 1 TATA binding IFT57 PF10498.9 EFO62047.1 - 0.0013 17.8 16.6 0.0013 17.8 16.6 2.1 1 1 0 2 2 2 1 Intra-flagellar transport protein 57 WD40_alt PF14077.6 EFO62047.1 - 0.019 14.8 0.1 0.084 12.8 0.1 2.1 1 0 0 1 1 1 0 Alternative WD40 repeat motif IF-2B PF01008.17 EFO62047.1 - 0.022 14.0 11.6 0.27 10.4 2.8 2.6 1 1 1 2 2 2 0 Initiation factor 2 subunit family DUF5082 PF16888.5 EFO62047.1 - 0.65 10.3 27.5 0.048 13.9 5.4 3.9 2 2 2 4 4 4 0 Domain of unknown function (DUF5082) DUF3573 PF12097.8 EFO62047.1 - 6 5.6 5.0 1.6 7.5 1.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3573) ATG16 PF08614.11 EFO62047.1 - 8.6 6.5 50.9 0.89 9.7 21.5 3.3 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) HrpB7 PF09486.10 EFO62047.1 - 9.2 6.6 45.2 2.3 8.6 10.5 3.3 1 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) FERM_M PF00373.18 EFO62048.1 - 0.0028 18.1 0.1 0.004 17.5 0.1 1.2 1 0 0 1 1 1 1 FERM central domain Myosin_TH1 PF06017.13 EFO62048.1 - 0.077 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding NADH_4Fe-4S PF10589.9 EFO62049.1 - 0.13 12.4 0.1 0.53 10.4 0.0 2.0 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Dpy-30 PF05186.13 EFO62050.1 - 1.7e-09 37.2 0.0 3.6e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Dpy-30 motif BUD22 PF09073.10 EFO62050.1 - 9.9 5.4 63.8 0.044 13.1 26.2 3.8 2 1 0 3 3 3 0 BUD22 TatD_DNase PF01026.21 EFO62051.1 - 5.5e-35 121.0 0.0 1.1e-34 120.0 0.0 1.5 1 1 0 1 1 1 1 TatD related DNase VSP PF03302.13 EFO62052.1 - 4.2e-28 98.3 144.7 2.3e-16 59.7 47.2 4.6 1 1 3 4 4 4 3 Giardia variant-specific surface protein Ank_2 PF12796.7 EFO62054.1 - 8.5e-63 208.9 0.3 1.5e-17 63.9 0.0 5.2 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 EFO62054.1 - 1.6e-44 148.5 2.4 0.00022 21.5 0.0 10.1 10 0 0 10 10 10 9 Ankyrin repeat Ank_4 PF13637.6 EFO62054.1 - 1e-41 140.8 0.4 6.5e-10 39.4 0.0 7.1 6 2 1 7 7 7 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62054.1 - 2.5e-40 136.0 6.0 5.6e-08 32.9 0.0 8.8 2 2 7 9 9 9 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62054.1 - 8.6e-39 127.1 0.1 0.0012 19.1 0.0 10.1 10 0 0 10 10 10 9 Ankyrin repeat HemY_N PF07219.13 EFO62054.1 - 0.12 12.6 2.0 0.38 11.0 0.8 2.5 2 0 0 2 2 2 0 HemY protein N-terminus 3HCDH_RFF PF18321.1 EFO62054.1 - 0.47 10.9 5.0 23 5.5 0.0 4.5 5 1 0 5 5 5 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain RVT_1 PF00078.27 EFO62056.1 - 6.5e-11 42.2 0.0 9.2e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-met PF12874.7 EFO62056.1 - 0.015 15.6 0.2 0.062 13.7 0.0 2.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_9 PF16293.5 EFO62056.1 - 0.015 15.1 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) zf-C2H2 PF00096.26 EFO62057.1 - 0.0024 18.2 14.9 0.3 11.6 0.5 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFO62057.1 - 0.018 15.8 12.6 2 9.5 0.4 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EFO62057.1 - 0.02 14.7 1.0 0.02 14.7 1.0 2.9 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf_C2H2_ZHX PF18387.1 EFO62057.1 - 0.18 11.5 2.0 16 5.2 0.2 2.5 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_2 PF12756.7 EFO62057.1 - 0.19 12.1 4.3 8.9 6.7 0.1 3.1 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) GAGA PF09237.11 EFO62057.1 - 0.33 10.8 3.7 0.48 10.3 0.4 2.4 2 0 0 2 2 2 0 GAGA factor zf-C2H2_11 PF16622.5 EFO62057.1 - 0.53 10.1 6.2 0.06 13.1 1.1 2.0 2 0 0 2 2 2 0 zinc-finger C2H2-type CelTOS PF18659.1 EFO62058.1 - 0.015 15.8 0.2 0.023 15.1 0.2 1.4 1 0 0 1 1 1 0 Cell-traversal protein for ookinetes and sporozoites WRKY PF03106.15 EFO62058.1 - 0.038 14.2 0.6 0.11 12.8 0.2 1.8 2 0 0 2 2 2 0 WRKY DNA -binding domain Arf PF00025.21 EFO62059.1 - 3.8e-58 195.8 0.0 4.2e-58 195.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFO62059.1 - 8.7e-13 48.6 0.0 1.2e-12 48.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFO62059.1 - 5.3e-12 45.5 0.0 6.6e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFO62059.1 - 7.8e-10 38.4 0.7 0.00083 18.6 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EFO62059.1 - 1.3e-09 37.9 0.0 1.6e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFO62059.1 - 1.4e-08 34.4 0.0 1.7e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFO62059.1 - 1e-06 28.8 0.0 1.4e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFO62059.1 - 0.012 15.2 0.2 0.57 9.7 0.0 2.3 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EFO62059.1 - 0.045 13.3 0.1 0.19 11.3 0.1 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_24 PF13479.6 EFO62059.1 - 0.054 13.2 0.1 0.069 12.9 0.1 1.2 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.18 EFO62059.1 - 0.067 12.5 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase NTPase_1 PF03266.15 EFO62059.1 - 0.13 12.2 0.1 0.17 11.8 0.1 1.4 1 1 0 1 1 1 0 NTPase AAA_18 PF13238.6 EFO62059.1 - 0.16 12.5 0.0 0.21 12.2 0.0 1.3 1 1 0 1 1 1 0 AAA domain Ank_2 PF12796.7 EFO62060.1 - 4.9e-21 75.1 0.2 1.5e-05 25.4 0.0 3.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62060.1 - 8.5e-13 48.3 0.2 0.0055 17.0 0.1 6.1 3 2 3 6 6 6 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO62060.1 - 1.8e-12 47.1 0.1 0.09 13.3 0.0 6.0 6 0 0 6 6 6 3 Ankyrin repeat Ank_3 PF13606.6 EFO62060.1 - 1.5e-10 40.3 0.1 0.16 12.6 0.0 6.6 6 0 0 6 6 6 2 Ankyrin repeat Ank_4 PF13637.6 EFO62060.1 - 1.5e-09 38.2 0.3 0.029 15.0 0.0 4.4 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO62060.1 - 3.7e-07 29.8 0.0 0.0024 17.3 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62060.1 - 0.00041 19.7 0.1 0.18 11.1 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase HsbA PF12296.8 EFO62061.1 - 0.2 12.1 2.2 4 7.9 0.2 2.8 2 0 0 2 2 2 0 Hydrophobic surface binding protein A VSP PF03302.13 EFO62062.1 - 2.4e-33 115.6 178.1 4.1e-16 58.8 9.1 8.1 1 1 5 7 7 7 6 Giardia variant-specific surface protein AAA_16 PF13191.6 EFO62063.1 - 0.0019 18.6 1.2 0.0076 16.6 0.2 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFO62063.1 - 0.0021 18.3 0.4 0.32 11.3 0.0 2.7 2 1 1 3 3 3 2 AAA domain TrmB PF01978.19 EFO62063.1 - 0.028 14.3 0.1 1.3 8.9 0.1 2.5 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB AAA PF00004.29 EFO62063.1 - 0.15 12.5 0.5 3.4 8.1 0.2 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) SET PF00856.28 EFO62064.1 - 1.9e-07 31.6 0.0 7.1e-07 29.8 0.0 2.0 1 1 0 1 1 1 1 SET domain RPN1_C PF18051.1 EFO62064.1 - 0.14 12.2 0.0 0.57 10.3 0.0 2.0 2 0 0 2 2 2 0 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal Dzip-like_N PF13815.6 EFO62065.1 - 1.2e-07 31.7 0.0 3.3e-07 30.3 0.0 1.7 1 1 0 1 1 1 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal zf-C2H2 PF00096.26 EFO62065.1 - 0.0011 19.3 4.0 0.0024 18.2 4.0 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFO62065.1 - 0.02 15.7 4.2 0.056 14.3 4.2 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger Ank_2 PF12796.7 EFO62066.1 - 2.1e-30 105.1 5.1 4.7e-12 46.3 0.7 4.0 2 1 2 4 4 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO62066.1 - 4e-17 60.5 0.2 0.046 14.3 0.0 5.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EFO62066.1 - 2.6e-15 56.3 2.4 8.3e-05 22.8 0.0 4.9 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62066.1 - 2.8e-12 46.9 1.3 0.0065 17.0 0.1 5.4 4 1 2 6 6 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO62066.1 - 1.2e-11 44.5 1.1 0.22 12.1 0.1 6.0 5 0 0 5 5 5 2 Ankyrin repeat Fez1 PF06818.15 EFO62066.1 - 5.8e-09 36.7 84.0 0.0014 19.1 16.8 7.0 1 1 4 6 6 6 3 Fez1 ATG16 PF08614.11 EFO62066.1 - 1.4e-08 35.2 109.8 0.052 13.8 6.8 9.4 1 1 7 8 8 8 3 Autophagy protein 16 (ATG16) Spc7 PF08317.11 EFO62066.1 - 3.1e-06 26.3 101.2 0.014 14.3 19.7 8.0 2 1 6 9 9 9 6 Spc7 kinetochore protein DUF641 PF04859.12 EFO62066.1 - 4.1e-06 27.1 78.4 0.5 10.7 6.1 12.8 4 1 8 12 12 12 2 Plant protein of unknown function (DUF641) HMMR_N PF15905.5 EFO62066.1 - 4e-05 23.2 95.7 0.03 13.8 16.8 8.4 1 1 5 7 7 7 3 Hyaluronan mediated motility receptor N-terminal Myosin_tail_1 PF01576.19 EFO62066.1 - 0.0005 18.0 101.0 0.021 12.6 57.5 3.8 1 1 0 2 2 2 2 Myosin tail Fib_alpha PF08702.10 EFO62066.1 - 0.00096 19.3 67.1 0.11 12.7 6.0 9.0 2 2 7 9 9 9 5 Fibrinogen alpha/beta chain family Golgin_A5 PF09787.9 EFO62066.1 - 0.0011 18.5 90.3 0.0012 18.4 13.6 6.6 2 1 6 8 8 8 4 Golgin subfamily A member 5 Atg14 PF10186.9 EFO62066.1 - 0.0019 17.3 9.2 0.0019 17.3 9.2 7.7 3 2 3 8 8 8 3 Vacuolar sorting 38 and autophagy-related subunit 14 Phage_GP20 PF06810.11 EFO62066.1 - 0.0021 17.9 5.1 0.0021 17.9 5.1 10.7 3 2 7 10 10 9 1 Phage minor structural protein GP20 ING PF12998.7 EFO62066.1 - 0.0031 18.1 2.1 0.0031 18.1 2.1 7.8 3 3 4 7 7 6 2 Inhibitor of growth proteins N-terminal histone-binding Lebercilin PF15619.6 EFO62066.1 - 0.0033 17.1 17.8 0.0033 17.1 17.8 8.5 3 2 5 9 9 8 4 Ciliary protein causing Leber congenital amaurosis disease DUF3972 PF13118.6 EFO62066.1 - 0.0043 17.5 1.7 0.0043 17.5 1.7 8.0 7 2 2 9 9 8 1 Protein of unknown function (DUF3972) AAA_13 PF13166.6 EFO62066.1 - 0.005 15.6 75.4 0.0054 15.5 12.2 5.1 2 2 0 4 4 4 3 AAA domain Tropomyosin_1 PF12718.7 EFO62066.1 - 0.0079 16.3 5.6 0.0079 16.3 5.6 9.3 3 2 5 9 9 8 3 Tropomyosin like PKcGMP_CC PF16808.5 EFO62066.1 - 0.0092 15.8 0.1 0.0092 15.8 0.1 16.4 15 2 2 17 17 16 5 Coiled-coil N-terminus of cGMP-dependent protein kinase bZIP_1 PF00170.21 EFO62066.1 - 0.013 15.6 0.7 0.013 15.6 0.7 11.8 11 3 3 14 14 12 0 bZIP transcription factor Terminase_6C PF17289.2 EFO62066.1 - 0.15 12.1 2.3 2.5 8.2 1.4 2.9 2 0 0 2 2 2 0 Terminase RNaseH-like domain HOOK PF05622.12 EFO62066.1 - 0.43 8.7 96.3 0.018 13.2 15.1 5.3 3 2 2 5 5 5 0 HOOK protein DUF4407 PF14362.6 EFO62066.1 - 0.45 9.8 83.2 0.22 10.8 16.4 6.4 1 1 3 4 4 2 0 Domain of unknown function (DUF4407) Pox_A_type_inc PF04508.12 EFO62066.1 - 0.48 10.4 0.0 0.48 10.4 0.0 11.3 11 0 0 11 11 9 0 Viral A-type inclusion protein repeat GAS PF13851.6 EFO62066.1 - 0.59 9.5 93.1 0.018 14.4 10.4 8.2 2 2 4 7 7 7 0 Growth-arrest specific micro-tubule binding FPP PF05911.11 EFO62066.1 - 0.68 8.1 80.4 0.013 13.8 12.3 5.2 1 1 4 5 5 5 0 Filament-like plant protein, long coiled-coil YojJ PF10372.9 EFO62066.1 - 0.74 9.9 0.0 0.74 9.9 0.0 6.3 6 1 0 6 6 5 0 Bacterial membrane-spanning protein N-terminus ADIP PF11559.8 EFO62066.1 - 1.8 8.6 92.3 0.063 13.4 5.0 10.2 4 2 4 10 10 10 0 Afadin- and alpha -actinin-Binding Filament PF00038.21 EFO62066.1 - 2.5 7.6 89.4 0.047 13.3 5.8 7.2 1 1 3 6 6 6 0 Intermediate filament protein Adap_comp_sub PF00928.21 EFO62067.1 - 4.3e-77 259.0 0.0 5.3e-77 258.7 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EFO62067.1 - 3.9e-05 23.6 0.1 0.00028 20.9 0.0 2.3 2 1 0 2 2 2 1 Clathrin adaptor complex small chain SRP68 PF16969.5 EFO62068.1 - 3.2e-18 66.0 0.3 5.3e-18 65.3 0.3 1.3 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 Di19_C PF14571.6 EFO62068.1 - 0.0066 16.9 0.4 0.83 10.2 0.1 2.6 2 0 0 2 2 2 2 Stress-induced protein Di19, C-terminal TP_methylase PF00590.20 EFO62069.1 - 4e-19 69.4 0.1 8.1e-19 68.4 0.1 1.5 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Pkinase PF00069.25 EFO62070.1 - 9.7e-59 198.9 0.0 3e-58 197.3 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Ank_2 PF12796.7 EFO62070.1 - 1.5e-52 176.1 18.3 9.8e-16 58.1 0.3 4.1 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EFO62070.1 - 7.3e-41 140.2 0.0 1.3e-40 139.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_3 PF13606.6 EFO62070.1 - 2.8e-17 61.0 3.9 0.004 17.5 0.0 6.6 7 0 0 7 7 6 4 Ankyrin repeat Ank PF00023.30 EFO62070.1 - 1.4e-15 56.9 0.0 0.042 14.3 0.0 6.1 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 EFO62070.1 - 2.8e-13 50.1 3.8 0.0032 18.0 0.3 5.6 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62070.1 - 1.7e-12 47.3 6.5 0.00013 22.2 0.1 5.9 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Kinase-like PF14531.6 EFO62070.1 - 4.5e-07 29.5 0.0 9.7e-05 21.8 0.0 2.8 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 EFO62070.1 - 0.0057 16.6 0.0 0.028 14.3 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFO62070.1 - 0.11 11.3 0.0 0.4 9.4 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase ERAP1_C PF11838.8 EFO62070.1 - 0.11 12.1 2.2 1.3 8.5 1.1 2.3 1 1 1 2 2 2 0 ERAP1-like C-terminal domain Lactamase_B PF00753.27 EFO62071.1 - 1.9e-20 73.7 0.3 1.1e-19 71.2 0.3 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFO62071.1 - 0.031 13.8 0.1 0.051 13.1 0.1 1.3 1 1 0 1 1 1 0 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 EFO62071.1 - 0.04 13.3 0.0 0.068 12.6 0.0 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Ank_2 PF12796.7 EFO62072.1 - 2.9e-45 152.7 3.7 1.1e-13 51.6 0.0 4.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62072.1 - 7.4e-29 99.4 0.7 2.7e-06 27.6 0.0 6.4 2 2 4 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO62072.1 - 1.7e-28 97.8 1.6 0.00048 20.4 0.0 7.6 7 1 1 8 8 8 6 Ankyrin repeat Ank_3 PF13606.6 EFO62072.1 - 4.6e-27 91.1 0.3 0.0026 18.1 0.0 8.4 8 0 0 8 8 8 6 Ankyrin repeat Ank_4 PF13637.6 EFO62072.1 - 1.3e-20 73.5 5.4 3.9e-06 27.3 0.1 5.7 5 2 2 7 7 7 4 Ankyrin repeats (many copies) zf-C3HC4_3 PF13920.6 EFO62072.1 - 0.0055 16.5 1.7 0.012 15.5 1.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) CCDC144C PF14915.6 EFO62072.1 - 0.044 12.9 0.3 0.067 12.3 0.3 1.2 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region zf-RING_2 PF13639.6 EFO62072.1 - 0.047 14.0 2.6 0.098 13.0 2.6 1.5 1 0 0 1 1 1 0 Ring finger domain 3HCDH_RFF PF18321.1 EFO62072.1 - 0.13 12.7 1.2 23 5.5 0.0 4.2 5 0 0 5 5 5 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain YdfA_immunity PF12127.8 EFO62073.1 - 0.19 10.7 0.5 0.34 9.9 0.5 1.3 1 0 0 1 1 1 0 SigmaW regulon antibacterial PIF1 PF05970.14 EFO62074.1 - 1.3e-40 139.7 2.9 3.5e-34 118.6 0.0 2.9 3 1 0 3 3 3 2 PIF1-like helicase AAA_30 PF13604.6 EFO62074.1 - 7e-19 68.3 0.0 1.2e-18 67.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFO62074.1 - 1.6e-11 44.7 0.0 3.4e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EFO62074.1 - 8.5e-07 28.9 0.4 0.07 12.9 0.3 4.1 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EFO62074.1 - 1e-06 29.1 0.0 3e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EFO62074.1 - 0.00012 22.0 3.8 0.19 11.5 0.0 3.5 2 1 1 3 3 3 2 AAA domain Helicase_RecD PF05127.14 EFO62074.1 - 0.00041 20.3 0.0 0.00098 19.0 0.0 1.6 1 0 0 1 1 1 1 Helicase UvrD_C_2 PF13538.6 EFO62074.1 - 0.0052 16.6 0.0 0.013 15.3 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain DUF2075 PF09848.9 EFO62074.1 - 0.0065 15.7 0.0 0.44 9.7 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Bac_DnaA PF00308.18 EFO62074.1 - 0.0077 16.1 0.0 0.1 12.4 0.0 2.3 2 0 0 2 2 2 1 Bacterial dnaA protein T2SSE PF00437.20 EFO62074.1 - 0.012 14.6 0.0 0.027 13.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.6 EFO62074.1 - 0.02 15.3 0.0 0.055 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 EFO62074.1 - 0.023 15.1 0.0 0.059 13.8 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EFO62074.1 - 0.027 14.0 0.0 0.055 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 EFO62074.1 - 0.029 13.8 0.0 0.092 12.2 0.0 1.9 1 1 0 1 1 1 0 PhoH-like protein NACHT PF05729.12 EFO62074.1 - 0.033 14.1 0.0 0.071 13.0 0.0 1.6 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 EFO62074.1 - 0.051 13.6 0.0 0.2 11.6 0.0 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 EFO62074.1 - 0.054 13.2 0.1 0.73 9.5 0.0 2.3 1 1 1 2 2 2 0 IstB-like ATP binding protein DUF87 PF01935.17 EFO62074.1 - 0.067 13.3 2.4 0.52 10.4 0.1 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain ABC_tran PF00005.27 EFO62074.1 - 0.13 12.8 1.7 2.1 8.9 0.1 2.9 2 1 0 3 3 3 0 ABC transporter AAA_24 PF13479.6 EFO62074.1 - 0.15 11.7 0.0 0.34 10.6 0.0 1.5 2 0 0 2 2 1 0 AAA domain Herpes_Helicase PF02689.14 EFO62074.1 - 0.27 9.1 3.2 3.2 5.6 0.0 3.1 3 1 1 4 4 4 0 Helicase EF-hand_6 PF13405.6 EFO62075.1 - 5e-09 35.4 9.3 0.016 15.1 0.0 6.0 6 0 0 6 6 6 3 EF-hand domain EF-hand_7 PF13499.6 EFO62075.1 - 4.9e-08 33.3 0.4 1.1 9.7 0.0 5.4 5 0 0 5 5 5 2 EF-hand domain pair EF-hand_1 PF00036.32 EFO62075.1 - 2.4e-07 29.8 1.7 0.25 11.0 0.0 5.2 5 0 0 5 5 5 2 EF hand EF-hand_11 PF08976.11 EFO62075.1 - 0.034 15.0 0.1 73 4.3 0.0 4.3 4 0 0 4 4 4 0 EF-hand domain HTH_Tnp_Mu_2 PF09039.11 EFO62075.1 - 0.035 14.2 0.0 0.095 12.8 0.0 1.6 1 0 0 1 1 1 0 Mu DNA binding, I gamma subdomain DUF1411 PF07199.11 EFO62075.1 - 0.055 13.1 0.1 0.14 11.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) Lactamase_B PF00753.27 EFO62076.1 - 4.8e-21 75.7 0.5 8.2e-21 74.9 0.5 1.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFO62076.1 - 0.0018 17.8 0.1 0.004 16.7 0.1 1.6 2 0 0 2 2 2 1 Beta-lactamase superfamily domain PDEase_II PF02112.15 EFO62076.1 - 0.056 12.6 0.1 0.084 12.0 0.1 1.3 1 0 0 1 1 1 0 cAMP phosphodiesterases class-II Pardaxin PF07425.11 EFO62077.1 - 0.094 12.3 0.1 0.28 10.8 0.1 1.8 1 0 0 1 1 1 0 Pardaxin RRM_1 PF00076.22 EFO62078.1 - 0.00021 21.0 0.5 0.0041 16.9 0.5 2.4 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EFO62078.1 - 0.00039 20.4 1.9 0.00059 19.8 1.9 1.4 1 0 0 1 1 1 1 RNA binding motif Limkain-b1 PF11608.8 EFO62078.1 - 0.012 15.7 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 Limkain b1 Guanylate_kin PF00625.21 EFO62079.1 - 6.2e-46 156.4 0.0 7.6e-46 156.1 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase ABC_tran PF00005.27 EFO62079.1 - 4.7e-06 27.2 0.0 7e-06 26.6 0.0 1.5 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 EFO62079.1 - 2.6e-05 23.9 0.0 5e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 EFO62079.1 - 6.6e-05 23.1 0.3 0.00049 20.3 0.3 2.0 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFO62079.1 - 0.00045 20.8 0.8 0.0026 18.3 0.8 2.2 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EFO62079.1 - 0.0018 18.2 0.0 0.0043 17.0 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 EFO62079.1 - 0.002 18.0 0.4 0.0055 16.6 0.2 1.8 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFO62079.1 - 0.0021 18.6 0.2 0.0021 18.6 0.2 2.1 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFO62079.1 - 0.0025 17.6 0.0 0.0042 16.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EFO62079.1 - 0.0034 17.1 0.1 0.15 11.8 0.0 2.1 2 0 0 2 2 2 1 Cytidylate kinase CPT PF07931.12 EFO62079.1 - 0.0037 17.1 0.0 0.0045 16.8 0.0 1.4 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein ATPase_2 PF01637.18 EFO62079.1 - 0.0049 16.8 0.3 0.019 14.9 0.0 1.9 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EFO62079.1 - 0.0049 17.2 0.1 0.015 15.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFO62079.1 - 0.0067 16.8 0.1 0.0099 16.3 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 EFO62079.1 - 0.01 16.1 0.1 0.34 11.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EFO62079.1 - 0.015 14.5 0.0 0.027 13.7 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain MMR_HSR1 PF01926.23 EFO62079.1 - 0.021 14.9 0.1 0.036 14.1 0.1 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase NACHT PF05729.12 EFO62079.1 - 0.028 14.3 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain dNK PF01712.19 EFO62079.1 - 0.032 14.1 0.3 4.4 7.1 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase SMC_N PF02463.19 EFO62079.1 - 0.034 13.6 0.0 0.059 12.8 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_17 PF13207.6 EFO62079.1 - 0.034 14.6 0.3 9.5 6.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EFO62079.1 - 0.037 13.9 0.1 0.072 13.0 0.0 1.6 1 1 0 1 1 1 0 Rad17 P-loop domain NTPase_1 PF03266.15 EFO62079.1 - 0.038 13.9 0.0 0.06 13.3 0.0 1.5 1 1 0 1 1 1 0 NTPase AAA PF00004.29 EFO62079.1 - 0.042 14.3 0.0 0.11 12.9 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SRPRB PF09439.10 EFO62079.1 - 0.043 13.2 0.1 0.11 12.0 0.0 1.7 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit Zeta_toxin PF06414.12 EFO62079.1 - 0.056 12.7 0.1 0.18 11.1 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin G-alpha PF00503.20 EFO62079.1 - 0.062 12.5 0.1 0.062 12.5 0.1 1.2 1 1 0 1 1 1 0 G-protein alpha subunit T2SSE PF00437.20 EFO62079.1 - 0.063 12.3 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.6 EFO62079.1 - 0.069 13.2 0.0 0.17 11.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.18 EFO62079.1 - 0.073 12.6 0.0 0.61 9.6 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B cobW PF02492.19 EFO62079.1 - 0.12 12.0 0.2 0.29 10.7 0.1 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TsaE PF02367.17 EFO62079.1 - 0.15 12.0 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ASH PF15780.5 EFO62080.1 - 5.7e-41 138.7 24.4 0.0004 20.5 0.0 21.5 22 2 0 23 23 22 8 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF1573 PF07610.11 EFO62080.1 - 5.5e-11 42.4 0.0 0.77 9.8 0.0 9.9 10 0 0 10 10 10 2 Protein of unknown function (DUF1573) Motile_Sperm PF00635.26 EFO62080.1 - 2e-09 37.2 6.1 1.4 8.8 0.0 11.0 12 1 0 12 12 12 1 MSP (Major sperm protein) domain PapD-like PF14874.6 EFO62080.1 - 2.2e-08 34.2 6.3 3.6 7.8 0.0 9.6 12 0 0 12 12 11 2 Flagellar-associated PapD-like NPCBM_assoc PF10633.9 EFO62080.1 - 0.0064 16.7 0.0 0.089 13.1 0.0 3.1 3 0 0 3 3 3 1 NPCBM-associated, NEW3 domain of alpha-galactosidase SNN_cytoplasm PF09051.10 EFO62080.1 - 0.013 15.3 0.0 0.044 13.6 0.0 1.9 1 0 0 1 1 1 0 Stannin cytoplasmic MYCBPAP PF14646.6 EFO62080.1 - 0.037 13.0 0.0 31 3.4 0.0 4.4 4 0 0 4 4 4 0 MYCBP-associated protein family Hydin_ADK PF17213.3 EFO62080.1 - 0.17 12.1 0.0 0.17 12.1 0.0 3.8 5 0 0 5 5 5 0 Hydin Adenylate kinase-like domain Sec8_exocyst PF04048.14 EFO62080.1 - 1.4 8.8 6.4 6.6 6.6 0.7 3.0 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain V-ATPase_G PF03179.15 EFO62080.1 - 2.6 8.6 6.1 7.3 7.2 6.1 1.8 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit HIP1_clath_bdg PF16515.5 EFO62080.1 - 5.1 7.8 12.1 2 9.1 1.6 2.9 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 MscS_porin PF12795.7 EFO62080.1 - 7.2 6.1 13.7 0.83 9.1 4.2 2.4 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Thiolase_N PF00108.23 EFO62081.1 - 1.2e-35 123.1 1.6 4.2e-34 118.1 1.6 2.2 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFO62081.1 - 8.1e-16 57.8 2.4 1.1e-15 57.3 0.1 2.3 2 1 1 3 3 3 1 Thiolase, C-terminal domain Peptidase_C1 PF00112.23 EFO62082.1 - 1e-57 195.8 1.3 1.2e-57 195.5 1.3 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFO62082.1 - 0.00013 20.9 2.0 0.00043 19.2 0.4 2.3 2 1 1 3 3 3 1 Peptidase C1-like family Ank_2 PF12796.7 EFO62083.1 - 9.4e-16 58.2 6.9 6e-08 33.2 1.6 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62083.1 - 6.1e-10 39.4 1.4 0.031 14.8 0.0 4.7 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62083.1 - 3.1e-09 36.9 0.9 0.056 13.8 0.0 3.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62083.1 - 9.6e-08 31.7 1.4 3.7 8.4 0.0 6.0 5 0 0 5 5 5 1 Ankyrin repeat Ank PF00023.30 EFO62083.1 - 0.00014 22.2 1.2 0.63 10.6 0.0 4.9 4 1 1 5 5 5 1 Ankyrin repeat Csm1_N PF18504.1 EFO62083.1 - 0.36 11.2 41.2 0.12 12.7 2.3 7.8 6 2 1 7 7 7 0 Csm1 N-terminal domain PolyA_pol PF01743.20 EFO62083.1 - 2.8 8.4 10.4 5.3 7.5 0.3 4.8 4 1 0 5 5 5 0 Poly A polymerase head domain Mod_r PF07200.13 EFO62083.1 - 8.9 6.4 41.2 0.22 11.6 0.5 5.4 3 1 2 5 5 5 0 Modifier of rudimentary (Mod(r)) protein SLAC1 PF03595.17 EFO62084.1 - 0.0023 17.3 0.4 0.0026 17.1 0.4 1.1 1 0 0 1 1 1 1 Voltage-dependent anion channel Promethin PF16015.5 EFO62084.1 - 0.0084 16.0 2.0 0.015 15.2 2.0 1.4 1 0 0 1 1 1 1 Promethin DUF2909 PF11137.8 EFO62084.1 - 0.016 15.2 0.7 0.038 13.9 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2909) FBPase PF00316.20 EFO62085.1 - 0.096 12.2 0.0 5.7 6.4 0.0 2.6 2 0 0 2 2 2 0 Fructose-1-6-bisphosphatase, N-terminal domain VSP PF03302.13 EFO62086.1 - 1.3e-105 353.5 276.0 3.4e-76 256.7 82.0 8.0 1 1 7 8 8 8 6 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO62086.1 - 0.00081 19.5 20.3 0.00081 19.5 20.3 18.7 3 2 15 19 19 19 10 Furin-like repeat, cysteine-rich Ephrin_rec_like PF07699.13 EFO62086.1 - 0.0099 15.6 7.5 0.0099 15.6 7.5 22.8 15 7 10 26 26 26 3 Putative ephrin-receptor like DENN PF02141.21 EFO62088.1 - 5.9e-15 55.7 1.5 1.5e-14 54.4 0.4 2.4 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.18 EFO62088.1 - 6.8e-06 26.7 0.3 5.3e-05 23.9 0.3 2.7 1 1 0 1 1 1 1 uDENN domain dDENN PF03455.19 EFO62088.1 - 0.0016 18.4 4.8 0.0016 18.4 4.8 2.3 2 0 0 2 2 2 1 dDENN domain DUF4461 PF14688.6 EFO62088.1 - 0.046 13.5 0.0 0.088 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4461) WD40 PF00400.32 EFO62089.1 - 7.4e-11 42.4 5.6 6.1e-07 30.0 0.7 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO62089.1 - 2.8e-08 33.9 0.0 0.00011 22.4 0.0 3.8 2 2 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Katanin_con80 PF13925.6 EFO62089.1 - 1.6e-06 28.2 0.5 4.5e-06 26.8 0.5 1.8 1 1 0 1 1 1 1 con80 domain of Katanin eIF2A PF08662.11 EFO62089.1 - 0.0015 18.5 0.1 0.068 13.1 0.0 2.8 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Carb_kinase PF01256.17 EFO62090.1 - 1.7e-38 132.5 0.0 1.1e-21 77.5 0.0 2.0 2 0 0 2 2 2 2 Carbohydrate kinase Phos_pyr_kin PF08543.12 EFO62090.1 - 0.021 14.2 0.1 1.6 8.0 0.0 2.4 2 1 0 2 2 2 0 Phosphomethylpyrimidine kinase CBF PF03914.17 EFO62092.1 - 1.4e-12 48.0 0.7 1.4e-12 48.0 0.7 1.9 2 0 0 2 2 2 1 CBF/Mak21 family AAA PF00004.29 EFO62094.1 - 6.9e-13 49.2 0.1 1e-11 45.4 0.1 2.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFO62094.1 - 0.00024 20.9 0.1 0.0015 18.3 0.0 2.4 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain IQ PF00612.27 EFO62094.1 - 0.026 14.3 3.8 0.24 11.3 0.3 2.9 2 0 0 2 2 2 0 IQ calmodulin-binding motif AAA_16 PF13191.6 EFO62094.1 - 0.052 13.9 0.0 0.2 12.0 0.0 2.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EFO62094.1 - 0.15 12.3 0.2 1.7 8.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain Collagen PF01391.18 EFO62094.1 - 0.21 11.4 24.3 0.021 14.6 8.8 3.2 3 0 0 3 3 3 0 Collagen triple helix repeat (20 copies) NUFIP2 PF15293.6 EFO62094.1 - 0.5 9.2 8.0 0.026 13.5 0.7 2.0 2 0 0 2 2 2 0 Nuclear fragile X mental retardation-interacting protein 2 AP3D1 PF06375.11 EFO62094.1 - 4.8 7.4 13.7 3.6 7.8 1.2 3.1 3 0 0 3 3 3 0 AP-3 complex subunit delta-1 ERCC4 PF02732.15 EFO62095.1 - 2.1e-11 44.3 0.2 4.8e-11 43.1 0.2 1.6 1 0 0 1 1 1 1 ERCC4 domain DUF1859 PF08948.10 EFO62095.1 - 0.028 14.4 0.0 0.073 13.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1859) Ank_2 PF12796.7 EFO62096.1 - 1.2e-53 179.6 19.8 3.5e-14 53.1 0.0 6.8 2 1 6 8 8 8 6 Ankyrin repeats (3 copies) Ank PF00023.30 EFO62096.1 - 2.2e-31 106.9 2.9 7e-05 23.1 0.0 9.6 9 1 0 9 9 9 7 Ankyrin repeat Ank_5 PF13857.6 EFO62096.1 - 1.9e-30 104.5 11.0 2.7e-07 30.7 0.0 7.8 4 2 4 8 8 8 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62096.1 - 1e-24 86.6 11.0 6.5e-05 23.4 0.3 7.1 4 2 2 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62096.1 - 5.8e-24 81.6 9.9 0.0051 17.2 0.0 10.5 11 0 0 11 11 11 6 Ankyrin repeat Pkinase_Tyr PF07714.17 EFO62096.1 - 0.0058 16.0 0.0 0.0094 15.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_A14 PF05767.12 EFO62096.1 - 0.02 15.1 0.9 0.05 13.8 0.9 1.6 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 Pkinase PF00069.25 EFO62096.1 - 0.16 11.3 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain DUF585 PF04522.12 EFO62096.1 - 0.17 11.5 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF585) SNARE PF05739.19 EFO62097.1 - 0.0019 18.1 0.7 0.0019 18.1 0.7 2.2 2 0 0 2 2 2 1 SNARE domain Laminin_II PF06009.12 EFO62097.1 - 0.0033 17.5 2.9 0.0033 17.5 2.9 2.4 2 0 0 2 2 2 1 Laminin Domain II EMP24_GP25L PF01105.24 EFO62097.1 - 0.021 14.8 0.2 0.021 14.8 0.2 1.8 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD AAA_13 PF13166.6 EFO62097.1 - 0.03 13.0 13.7 0.17 10.5 2.4 2.0 2 0 0 2 2 2 0 AAA domain Jnk-SapK_ap_N PF09744.9 EFO62097.1 - 0.042 14.1 1.4 0.042 14.1 1.4 2.7 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 V-ATPase_G_2 PF16999.5 EFO62097.1 - 0.051 14.0 0.2 0.051 14.0 0.2 3.0 3 1 0 3 3 3 0 Vacuolar (H+)-ATPase G subunit Spc7 PF08317.11 EFO62097.1 - 0.077 11.9 19.6 0.089 11.7 4.1 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein Baculo_PEP_C PF04513.12 EFO62097.1 - 0.079 13.0 2.2 0.31 11.1 0.1 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus HrpB2 PF09487.10 EFO62097.1 - 0.096 13.1 2.4 0.31 11.5 0.8 2.3 2 1 1 3 3 2 0 Bacterial type III secretion protein (HrpB2) Peptidase_S41_N PF11918.8 EFO62097.1 - 0.1 12.9 1.5 0.35 11.1 0.0 2.2 2 0 0 2 2 2 0 N-terminal domain of Peptidase_S41 in eukaryotic IRBP IFT57 PF10498.9 EFO62097.1 - 0.12 11.4 10.9 0.029 13.3 1.4 2.2 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 TMPIT PF07851.13 EFO62097.1 - 0.13 11.5 6.9 0.89 8.7 0.1 2.3 2 0 0 2 2 2 0 TMPIT-like protein GARP PF16731.5 EFO62097.1 - 0.15 11.8 7.5 0.12 12.0 4.1 2.2 2 0 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma DUF1664 PF07889.12 EFO62097.1 - 0.15 12.1 11.8 0.83 9.7 4.9 2.9 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) TMEM214 PF10151.9 EFO62097.1 - 0.19 10.2 3.0 0.076 11.5 0.2 1.6 2 0 0 2 2 2 0 TMEM214, C-terminal, caspase 4 activator DASH_Dam1 PF08653.10 EFO62097.1 - 0.26 11.1 0.9 13 5.7 0.1 3.4 2 1 1 3 3 3 0 DASH complex subunit Dam1 DASH_Duo1 PF08651.10 EFO62097.1 - 0.27 11.0 5.9 0.33 10.7 0.4 3.5 3 2 2 5 5 5 0 DASH complex subunit Duo1 Spectrin PF00435.21 EFO62097.1 - 0.27 11.7 15.0 0.33 11.5 2.5 2.6 3 0 0 3 3 2 0 Spectrin repeat Fib_alpha PF08702.10 EFO62097.1 - 0.3 11.3 10.4 0.62 10.2 0.9 2.7 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Syntaxin_2 PF14523.6 EFO62097.1 - 0.31 11.4 11.2 5.2 7.5 0.7 3.8 2 2 1 4 4 3 0 Syntaxin-like protein DUF948 PF06103.11 EFO62097.1 - 0.34 11.2 6.2 0.73 10.1 3.9 2.6 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF948) T3SSipB PF16535.5 EFO62097.1 - 0.38 11.2 5.1 0.26 11.7 1.1 2.3 2 1 1 3 3 3 0 Type III cell invasion protein SipB Sec34 PF04136.15 EFO62097.1 - 0.39 10.6 6.6 0.52 10.2 1.1 3.0 2 2 1 3 3 3 0 Sec34-like family Laminin_I PF06008.14 EFO62097.1 - 0.42 10.3 11.7 0.035 13.8 3.3 2.3 2 1 1 3 3 2 0 Laminin Domain I DUF573 PF04504.14 EFO62097.1 - 0.45 11.2 5.9 1.1 9.9 1.2 2.5 2 1 0 2 2 2 0 Protein of unknown function, DUF573 Fez1 PF06818.15 EFO62097.1 - 0.52 10.7 17.4 0.068 13.6 2.7 2.3 2 1 0 2 2 2 0 Fez1 DUF4407 PF14362.6 EFO62097.1 - 0.52 9.6 6.6 2.3 7.5 5.8 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Synaptobrevin PF00957.21 EFO62097.1 - 0.54 10.1 4.5 0.7 9.7 1.4 2.4 2 0 0 2 2 2 0 Synaptobrevin CheZ PF04344.13 EFO62097.1 - 0.55 10.1 6.0 0.43 10.5 1.2 2.4 2 1 0 2 2 2 0 Chemotaxis phosphatase, CheZ Borrelia_REV PF03978.13 EFO62097.1 - 0.62 10.0 8.4 0.17 11.9 1.0 2.7 2 2 0 2 2 2 0 Borrelia burgdorferi REV protein ArdA PF07275.11 EFO62097.1 - 0.7 10.5 4.0 3 8.4 0.1 2.4 1 1 1 2 2 2 0 Antirestriction protein (ArdA) NPV_P10 PF05531.12 EFO62097.1 - 0.77 10.3 6.4 7.7 7.1 2.5 3.6 3 2 1 4 4 3 0 Nucleopolyhedrovirus P10 protein DUF4208 PF13907.6 EFO62097.1 - 1.1 9.8 4.8 0.86 10.1 0.8 2.7 2 2 0 2 2 2 0 Domain of unknown function (DUF4208) DUF16 PF01519.16 EFO62097.1 - 1.5 9.4 11.0 0.072 13.6 1.0 2.8 2 1 0 2 2 2 0 Protein of unknown function DUF16 Cluap1 PF10234.9 EFO62097.1 - 2.3 7.6 12.1 0.84 9.0 3.1 2.2 2 0 0 2 2 2 0 Clusterin-associated protein-1 DUF724 PF05266.14 EFO62097.1 - 2.6 7.8 17.0 1.5 8.6 5.8 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF724) DUF1515 PF07439.11 EFO62097.1 - 4.3 7.4 6.0 0.66 10.0 0.6 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1515) UPF0242 PF06785.11 EFO62097.1 - 5 7.2 19.3 0.7 10.0 2.1 3.0 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus BLOC1_2 PF10046.9 EFO62097.1 - 8.8 6.7 14.5 2 8.8 3.1 3.9 2 2 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4573 PF15140.6 EFO62099.1 - 0.0067 16.2 0.3 0.038 13.8 0.0 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4573) HALZ PF02183.18 EFO62099.1 - 0.0079 16.4 17.3 4.7 7.5 0.2 4.7 4 0 0 4 4 4 2 Homeobox associated leucine zipper Spc7 PF08317.11 EFO62099.1 - 0.012 14.5 21.7 0.0081 15.1 15.5 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein RCS1 PF07326.11 EFO62099.1 - 0.016 15.2 0.6 0.035 14.1 0.0 1.8 2 0 0 2 2 2 0 Regulator of chromosome segregation 1 Seryl_tRNA_N PF02403.22 EFO62099.1 - 0.042 14.1 15.6 0.2 11.9 3.1 3.6 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Fez1 PF06818.15 EFO62099.1 - 0.1 13.0 18.1 0.31 11.5 10.0 2.3 1 1 1 2 2 2 0 Fez1 PI_PP_I PF18363.1 EFO62099.1 - 0.34 11.1 2.1 0.77 10.0 0.5 2.5 1 1 1 2 2 2 0 Phosphoinositide phosphatase insertion domain Jnk-SapK_ap_N PF09744.9 EFO62099.1 - 0.39 10.9 23.0 0.58 10.4 8.8 3.1 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 DUF5320 PF17253.2 EFO62099.1 - 0.56 11.3 6.4 4.3 8.5 0.0 3.5 3 1 0 4 4 3 0 Family of unknown function (DUF5320) DUF4407 PF14362.6 EFO62099.1 - 0.7 9.2 15.7 7.7 5.8 15.7 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Mto2_bdg PF12808.7 EFO62099.1 - 1.4 9.3 7.5 4 7.8 1.4 3.0 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region LMBR1 PF04791.16 EFO62099.1 - 2 7.2 7.1 4.2 6.2 7.1 1.5 1 0 0 1 1 1 0 LMBR1-like membrane protein Tup_N PF08581.10 EFO62099.1 - 2.5 8.5 19.2 2.3 8.6 1.9 3.3 3 0 0 3 3 3 0 Tup N-terminal ZapB PF06005.12 EFO62099.1 - 2.5 8.6 26.5 3.1 8.3 0.3 4.9 4 1 0 4 4 4 0 Cell division protein ZapB TACC_C PF05010.14 EFO62099.1 - 2.9 7.6 20.4 0.8 9.4 15.9 2.1 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal HrpB7 PF09486.10 EFO62099.1 - 3.1 8.2 6.9 0.86 10.0 2.6 2.2 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) LemA PF04011.12 EFO62099.1 - 4.6 7.1 12.1 3.2 7.6 1.6 2.7 1 1 1 2 2 2 0 LemA family Occludin_ELL PF07303.13 EFO62099.1 - 5 7.9 17.7 0.52 11.1 5.6 3.9 4 0 0 4 4 3 0 Occludin homology domain DUF2951 PF11166.8 EFO62099.1 - 5.7 7.2 6.0 18 5.7 6.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) DivIC PF04977.15 EFO62099.1 - 7 6.5 20.3 1.6 8.5 0.3 4.6 3 1 1 4 4 4 0 Septum formation initiator APG6_N PF17675.1 EFO62099.1 - 7.7 7.1 25.6 7.6 7.1 2.0 3.5 1 1 2 3 3 3 0 Apg6 coiled-coil region DUF4763 PF15960.5 EFO62099.1 - 9.3 5.5 16.3 9.9 5.4 3.5 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) TolA_bind_tri PF16331.5 EFO62099.1 - 9.5 6.4 20.1 0.13 12.3 4.8 3.8 3 1 1 4 4 4 0 TolA binding protein trimerisation DUF5059 PF16502.5 EFO62100.1 - 0.01 14.6 0.3 0.013 14.3 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5059) PGM_PMM_I PF02878.16 EFO62101.1 - 5.2e-24 84.5 0.0 1.4e-23 83.1 0.0 1.7 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EFO62101.1 - 1.6e-15 57.3 0.0 2.9e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EFO62101.1 - 2.8e-15 56.8 0.0 6.5e-15 55.6 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EFO62101.1 - 1.8e-05 24.8 0.0 5.1e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PSDC PF12588.8 EFO62101.1 - 0.13 12.2 0.1 0.3 11.0 0.1 1.6 1 0 0 1 1 1 0 Phophatidylserine decarboxylase CCDC106 PF15794.5 EFO62102.1 - 0.36 10.5 14.3 0.47 10.1 14.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF4662 PF15578.6 EFO62102.1 - 3.6 7.3 12.0 3.7 7.3 11.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4662) EOS1 PF12326.8 EFO62102.1 - 3.7 7.4 5.6 5.5 6.9 5.6 1.2 1 0 0 1 1 1 0 N-glycosylation protein Swi5 PF07061.11 EFO62103.1 - 0.0056 16.7 4.3 0.026 14.6 1.5 2.6 1 1 1 2 2 2 1 Swi5 Cytochrom_B562 PF07361.11 EFO62103.1 - 0.018 15.7 0.0 0.025 15.3 0.0 1.3 1 0 0 1 1 1 0 Cytochrome b562 SYF2 PF08231.12 EFO62103.1 - 0.059 13.8 0.1 0.074 13.4 0.1 1.1 1 0 0 1 1 1 0 SYF2 splicing factor DARPP-32 PF05395.12 EFO62104.1 - 0.084 13.1 0.2 0.11 12.7 0.2 1.2 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 PX PF00787.24 EFO62106.1 - 3.3e-13 49.6 0.0 4.6e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 PX domain RNA_pol_Rpb6 PF01192.22 EFO62107.1 - 4.9e-14 52.0 0.0 6.5e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb6 DUF4115 PF13464.6 EFO62107.1 - 0.18 12.0 0.0 0.22 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4115) WD40 PF00400.32 EFO62110.1 - 2.1e-11 44.2 15.0 0.00025 21.8 0.0 8.3 10 0 0 10 10 10 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO62110.1 - 0.00056 20.2 0.0 13 6.1 0.0 5.4 5 2 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain SGL PF08450.12 EFO62110.1 - 0.0038 16.9 0.3 4.3 6.9 0.0 4.2 3 1 1 4 4 4 1 SMP-30/Gluconolactonase/LRE-like region PQQ_2 PF13360.6 EFO62110.1 - 0.0049 16.5 0.0 1.2 8.7 0.0 2.5 1 1 0 2 2 2 2 PQQ-like domain Hira PF07569.11 EFO62110.1 - 0.0067 16.2 0.1 2.5 7.8 0.1 3.9 4 0 0 4 4 4 1 TUP1-like enhancer of split Nup160 PF11715.8 EFO62110.1 - 0.0073 15.0 0.0 0.026 13.2 0.0 1.8 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EFO62110.1 - 0.018 13.6 0.0 7.5 5.0 0.0 3.2 4 0 0 4 4 4 0 Cytochrome D1 heme domain GYF PF02213.16 EFO62111.1 - 1e-11 44.3 0.0 1.8e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 GYF domain NLPC_P60 PF00877.19 EFO62112.1 - 0.00076 19.5 0.0 0.0014 18.7 0.0 1.5 1 0 0 1 1 1 1 NlpC/P60 family KH_1 PF00013.29 EFO62116.1 - 2.9e-08 33.4 0.2 0.001 18.9 0.0 2.8 2 0 0 2 2 2 2 KH domain KH_2 PF07650.17 EFO62116.1 - 0.051 13.4 0.3 9.9 6.1 0.0 2.5 2 0 0 2 2 2 0 KH domain KH_5 PF13184.6 EFO62116.1 - 0.06 13.4 0.8 2.5 8.2 0.1 2.9 2 1 1 3 3 3 0 NusA-like KH domain DUF1730 PF08331.10 EFO62116.1 - 0.15 12.0 0.0 0.35 10.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1730) E2F_TDP PF02319.20 EFO62118.1 - 0.00012 22.0 0.0 0.00028 20.9 0.0 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain MORN PF02493.20 EFO62119.1 - 1e-06 28.3 8.4 0.0012 18.6 0.2 3.2 3 0 0 3 3 3 2 MORN repeat CBFD_NFYB_HMF PF00808.23 EFO62120.1 - 6e-05 23.2 1.7 7.1e-05 23.0 1.7 1.1 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone V-ATPase_H_C PF11698.8 EFO62121.1 - 1.7e-26 92.6 0.1 4.2e-26 91.3 0.1 1.7 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_N PF03224.14 EFO62121.1 - 4.5e-05 22.9 0.4 0.00012 21.5 0.0 1.9 2 0 0 2 2 2 1 V-ATPase subunit H Peptidase_M16 PF00675.20 EFO62122.1 - 5.3e-08 33.0 0.0 1.1e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Baculo_LEF-11 PF06385.12 EFO62123.1 - 0.003 18.0 4.9 0.0097 16.4 0.5 2.7 2 1 1 3 3 3 1 Baculovirus LEF-11 protein NUC130_3NT PF08158.12 EFO62123.1 - 0.0085 16.4 3.2 0.032 14.6 0.9 2.8 2 1 0 2 2 2 1 NUC130/3NT domain THP2 PF09432.10 EFO62123.1 - 0.095 12.8 2.1 0.36 10.9 0.2 2.3 1 1 1 2 2 2 0 Tho complex subunit THP2 Sld5 PF05916.11 EFO62123.1 - 0.17 12.3 1.6 0.58 10.6 0.8 2.1 1 1 1 2 2 2 0 GINS complex protein Rrp15p PF07890.12 EFO62124.1 - 6.9e-07 29.7 1.7 1e-06 29.1 1.7 1.2 1 0 0 1 1 1 1 Rrp15p F_actin_bind PF08919.10 EFO62124.1 - 0.072 13.2 0.1 0.16 12.1 0.1 1.5 1 1 0 1 1 1 0 F-actin binding VSP PF03302.13 EFO62126.1 - 3.4e-93 312.6 107.0 3.6e-49 167.7 29.4 5.9 1 1 5 6 6 6 6 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO62126.1 - 0.58 10.2 5.4 0.3 11.2 0.2 2.4 2 0 0 2 2 2 0 Podoplanin zf-C2H2_jaz PF12171.8 EFO62128.1 - 4.7e-05 23.6 1.3 0.048 14.0 0.5 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EFO62128.1 - 0.00053 20.6 7.2 0.42 11.6 0.6 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EFO62128.1 - 0.00081 19.7 0.8 0.97 10.0 0.0 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-met PF12874.7 EFO62128.1 - 0.004 17.5 1.3 0.4 11.1 0.0 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_9 PF16293.5 EFO62128.1 - 0.0049 16.7 1.5 0.035 14.0 0.1 2.3 2 0 0 2 2 2 1 C2H2 type zinc-finger (1 copy) zf-Di19 PF05605.12 EFO62128.1 - 0.0061 16.8 1.8 1.4 9.2 0.3 2.5 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding Zn-C2H2_12 PF18112.1 EFO62128.1 - 0.016 15.6 0.4 2.8 8.5 0.1 2.4 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_2 PF12756.7 EFO62128.1 - 0.092 13.1 0.8 9.7 6.6 0.3 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.6 EFO62128.1 - 0.94 10.0 3.4 7 7.3 0.8 2.8 2 0 0 2 2 2 0 Zinc-finger double domain VSP PF03302.13 EFO62130.1 - 1.2e-68 231.8 156.6 3e-36 125.1 30.1 5.3 1 1 4 5 5 5 4 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO62130.1 - 0.022 14.9 2.7 0.022 14.9 2.7 9.6 1 1 9 10 10 10 0 Furin-like repeat, cysteine-rich SKG6 PF08693.10 EFO62130.1 - 0.055 12.9 4.8 0.12 11.8 4.8 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Podoplanin PF05808.11 EFO62130.1 - 0.088 12.9 2.4 0.27 11.3 2.4 1.8 1 0 0 1 1 1 0 Podoplanin Pkinase PF00069.25 EFO62131.1 - 8.7e-30 104.0 0.0 2.1e-29 102.7 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62131.1 - 5.8e-21 74.9 0.0 7.9e-21 74.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase LPP PF04728.13 EFO62131.1 - 0.049 14.0 0.1 6.8 7.2 0.0 2.4 2 0 0 2 2 2 0 Lipoprotein leucine-zipper BLOC1_2 PF10046.9 EFO62131.1 - 0.077 13.3 0.1 0.13 12.6 0.1 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HOOK PF05622.12 EFO62131.1 - 0.11 10.6 0.1 0.15 10.2 0.1 1.1 1 0 0 1 1 1 0 HOOK protein Ank_2 PF12796.7 EFO62132.1 - 1.1e-107 352.8 21.8 2.4e-14 53.7 0.0 10.1 1 1 9 10 10 10 10 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO62132.1 - 3.4e-64 205.2 13.9 0.00025 21.2 0.0 19.1 19 0 0 19 19 19 16 Ankyrin repeat Ank_4 PF13637.6 EFO62132.1 - 1.5e-63 210.4 18.7 2.4e-08 34.4 0.1 13.2 9 4 5 14 14 14 13 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62132.1 - 1.2e-62 207.1 33.8 0.0002 21.6 0.0 16.6 4 4 10 16 16 16 16 Ankyrin repeats (many copies) Ank PF00023.30 EFO62132.1 - 8.6e-57 187.2 29.6 0.00021 21.6 0.0 18.8 17 2 2 19 19 19 14 Ankyrin repeat zf-RRN7 PF11781.8 EFO62136.1 - 4.9e-05 22.9 0.2 9.4e-05 22.0 0.2 1.4 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 TF_Zn_Ribbon PF08271.12 EFO62136.1 - 0.0017 17.8 1.7 0.0041 16.6 1.7 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding BRX_N PF13713.6 EFO62136.1 - 0.018 14.8 0.1 0.049 13.4 0.1 1.7 1 0 0 1 1 1 0 Transcription factor BRX N-terminal domain Cyclin_N PF00134.23 EFO62136.1 - 0.025 14.3 0.3 0.057 13.2 0.3 1.6 1 0 0 1 1 1 0 Cyclin, N-terminal domain Viral_helicase1 PF01443.18 EFO62136.1 - 0.028 14.1 0.0 0.068 12.9 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RB_B PF01857.20 EFO62136.1 - 0.07 13.2 0.1 0.2 11.7 0.1 1.8 1 0 0 1 1 1 0 Retinoblastoma-associated protein B domain Zn_Tnp_IS1595 PF12760.7 EFO62136.1 - 0.071 13.1 1.1 0.14 12.2 1.1 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain TFIIB PF00382.19 EFO62136.1 - 0.08 13.0 0.9 0.28 11.3 0.6 2.1 1 1 0 1 1 1 0 Transcription factor TFIIB repeat zf-TFIIB PF13453.6 EFO62136.1 - 1.3 8.5 3.9 2.6 7.5 3.9 1.5 1 0 0 1 1 1 0 Transcription factor zinc-finger PP2C PF00481.21 EFO62137.1 - 5.1e-38 131.2 0.0 2.6e-26 92.8 0.0 2.5 2 0 0 2 2 2 2 Protein phosphatase 2C LRR_6 PF13516.6 EFO62137.1 - 3.4e-06 26.7 8.9 0.00019 21.2 0.0 5.2 5 0 0 5 5 5 1 Leucine Rich repeat LRR_4 PF12799.7 EFO62137.1 - 0.0012 19.2 1.7 0.17 12.4 0.0 3.8 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO62137.1 - 0.0018 18.0 1.8 0.45 10.3 0.0 3.3 3 1 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 EFO62137.1 - 0.0097 16.3 1.1 6.5 7.7 0.1 4.3 4 0 0 4 4 4 1 Leucine Rich Repeat TSKS PF15358.6 EFO62138.1 - 0.027 12.9 0.3 0.051 12.0 0.3 1.3 1 0 0 1 1 1 0 Testis-specific serine kinase substrate Exotox-A_bind PF09101.10 EFO62138.1 - 0.13 11.6 0.0 16 4.8 0.0 2.3 2 0 0 2 2 2 0 Exotoxin A binding GTP-bdg_M PF16360.5 EFO62138.1 - 0.14 12.8 0.2 0.31 11.7 0.2 1.6 1 0 0 1 1 1 0 GTP-binding GTPase Middle Region SopA_C PF13979.6 EFO62139.1 - 0.065 13.0 0.2 0.2 11.4 0.0 1.8 3 0 0 3 3 3 0 SopA-like catalytic domain Pkinase PF00069.25 EFO62140.1 - 6e-61 206.1 0.0 9.8e-61 205.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62140.1 - 8.8e-34 117.0 0.0 2.3e-33 115.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO62140.1 - 2.8e-33 114.4 4.6 2.9e-15 56.6 1.0 4.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62140.1 - 5.3e-24 84.0 4.1 1.9e-05 24.8 0.2 6.1 2 2 4 6 6 6 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62140.1 - 2.7e-22 78.8 2.4 3.4e-07 30.7 0.0 5.4 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO62140.1 - 4e-22 77.6 2.4 0.013 15.9 0.0 7.0 5 1 1 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 EFO62140.1 - 5.7e-20 69.3 3.1 0.014 15.9 0.0 7.3 7 0 0 7 7 7 5 Ankyrin repeat AAA PF00004.29 EFO62141.1 - 1.2e-15 58.1 0.0 5.9e-15 55.9 0.0 2.0 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EFO62141.1 - 2.1e-10 40.6 0.1 1.1e-08 35.0 0.0 2.7 2 1 0 2 2 2 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 EFO62141.1 - 1.3e-07 32.1 0.1 4.4e-05 23.9 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EFO62141.1 - 8.8e-07 29.3 0.2 4.8e-05 23.7 0.2 2.8 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EFO62141.1 - 1.9e-05 25.0 0.0 5.8e-05 23.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFO62141.1 - 2.1e-05 24.3 0.0 0.00016 21.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFO62141.1 - 2.5e-05 24.1 0.0 7.6e-05 22.5 0.0 1.8 2 0 0 2 2 1 1 AAA domain RuvB_N PF05496.12 EFO62141.1 - 0.00035 20.4 0.1 0.0053 16.5 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EFO62141.1 - 0.00043 19.5 0.0 0.001 18.3 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 EFO62141.1 - 0.00045 19.7 0.0 0.01 15.2 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ResIII PF04851.15 EFO62141.1 - 0.00055 20.0 0.0 0.1 12.6 0.0 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_29 PF13555.6 EFO62141.1 - 0.0011 18.7 0.0 0.0023 17.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_5 PF07728.14 EFO62141.1 - 0.0011 19.0 0.0 0.0035 17.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EFO62141.1 - 0.002 17.7 0.0 0.0031 17.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_11 PF13086.6 EFO62141.1 - 0.0024 17.7 0.2 0.036 13.8 0.0 2.6 2 1 1 3 3 3 1 AAA domain ATPase_2 PF01637.18 EFO62141.1 - 0.0048 16.8 0.0 0.01 15.8 0.0 1.6 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea FtsK_SpoIIIE PF01580.18 EFO62141.1 - 0.0068 15.8 0.1 0.018 14.4 0.0 1.7 2 0 0 2 2 2 1 FtsK/SpoIIIE family TniB PF05621.11 EFO62141.1 - 0.007 15.8 0.0 0.13 11.6 0.0 2.4 2 0 0 2 2 2 1 Bacterial TniB protein NACHT PF05729.12 EFO62141.1 - 0.0073 16.2 0.0 0.04 13.8 0.0 2.3 1 1 0 1 1 1 1 NACHT domain AAA_14 PF13173.6 EFO62141.1 - 0.0073 16.3 0.0 0.018 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 EFO62141.1 - 0.0092 15.9 0.0 0.046 13.7 0.0 2.1 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 EFO62141.1 - 0.012 15.9 0.0 0.027 14.8 0.0 1.6 1 0 0 1 1 1 0 AAA C-terminal domain AAA_25 PF13481.6 EFO62141.1 - 0.014 15.0 0.0 0.038 13.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EFO62141.1 - 0.014 14.6 0.0 0.031 13.5 0.0 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TsaE PF02367.17 EFO62141.1 - 0.015 15.3 0.0 0.046 13.7 0.0 1.8 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 EFO62141.1 - 0.019 14.1 0.0 0.038 13.2 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain T2SSE PF00437.20 EFO62141.1 - 0.024 13.7 0.0 0.051 12.6 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein PIF1 PF05970.14 EFO62141.1 - 0.026 13.7 0.0 1.2 8.2 0.0 2.1 2 0 0 2 2 2 0 PIF1-like helicase Rep_fac_C PF08542.11 EFO62141.1 - 0.028 14.8 0.0 1.1 9.8 0.0 2.4 2 0 0 2 2 2 0 Replication factor C C-terminal domain DEAD PF00270.29 EFO62141.1 - 0.03 14.1 0.3 0.74 9.6 0.0 2.4 1 1 0 2 2 2 0 DEAD/DEAH box helicase Sigma54_activat PF00158.26 EFO62141.1 - 0.039 13.6 0.0 0.25 11.0 0.0 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain PhoH PF02562.16 EFO62141.1 - 0.04 13.4 0.1 1.1 8.7 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein AAA_23 PF13476.6 EFO62141.1 - 0.045 14.3 0.0 0.099 13.1 0.0 1.6 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 EFO62141.1 - 0.05 14.0 0.0 0.092 13.1 0.0 1.6 1 1 0 1 1 1 0 RNA helicase TrwB_AAD_bind PF10412.9 EFO62141.1 - 0.057 12.3 0.4 0.11 11.4 0.1 1.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain ATP_bind_1 PF03029.17 EFO62141.1 - 0.072 12.9 0.1 1.6 8.4 0.0 2.5 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Bac_DnaA PF00308.18 EFO62141.1 - 0.091 12.6 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial dnaA protein RsgA_GTPase PF03193.16 EFO62141.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase cobW PF02492.19 EFO62141.1 - 0.11 12.0 0.0 0.25 10.9 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 EFO62141.1 - 0.11 13.0 0.2 0.36 11.3 0.0 1.9 3 0 0 3 3 1 0 ABC transporter Parvo_NS1 PF01057.17 EFO62141.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 IstB_IS21 PF01695.17 EFO62141.1 - 0.12 12.1 2.6 1.8 8.3 0.0 2.9 4 0 0 4 4 3 0 IstB-like ATP binding protein AAA_33 PF13671.6 EFO62141.1 - 0.15 12.2 0.1 0.43 10.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain V-ATPase_H_C PF11698.8 EFO62141.1 - 0.15 12.1 0.0 0.68 10.1 0.0 2.0 1 1 0 1 1 1 0 V-ATPase subunit H CRT-like PF08627.10 EFO62143.1 - 0.31 9.9 15.7 0.0092 15.0 8.3 2.1 2 0 0 2 2 2 0 CRT-like, chloroquine-resistance transporter-like VSP PF03302.13 EFO62144.1 - 2.9e-79 266.8 109.9 1.2e-40 139.7 65.7 3.0 1 1 2 3 3 3 3 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO62144.1 - 0.004 17.3 0.2 0.0091 16.1 0.0 1.7 2 0 0 2 2 2 1 Podoplanin Furin-like_2 PF15913.5 EFO62144.1 - 0.019 15.1 80.5 0.022 14.9 13.0 6.5 1 1 5 6 6 6 0 Furin-like repeat, cysteine-rich Transglut_core PF01841.19 EFO62145.1 - 0.042 14.3 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 Transglutaminase-like superfamily DUF1652 PF07865.11 EFO62145.1 - 0.11 12.4 0.1 3.5 7.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1652) Pkinase PF00069.25 EFO62146.1 - 7.4e-54 182.9 0.0 1.4e-53 181.9 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62146.1 - 1.9e-31 109.3 0.0 2.5e-30 105.6 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO62146.1 - 1.9e-26 92.4 11.0 7.8e-09 36.0 0.6 3.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62146.1 - 1.1e-19 70.5 4.2 2.9e-05 24.5 0.0 4.7 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62146.1 - 1.7e-15 56.8 9.9 0.00056 20.2 0.1 5.4 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO62146.1 - 2e-14 53.3 8.6 0.013 16.0 0.0 6.4 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 EFO62146.1 - 3.3e-14 51.6 10.7 0.0035 17.7 0.0 6.5 7 0 0 7 7 7 4 Ankyrin repeat Pkinase_fungal PF17667.1 EFO62146.1 - 1e-05 24.5 0.6 3.4e-05 22.8 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EFO62146.1 - 9.1e-05 21.9 0.0 0.00061 19.2 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EFO62146.1 - 0.11 12.4 0.1 0.42 10.5 0.1 2.0 1 1 0 2 2 2 0 Phosphotransferase enzyme family LRR_6 PF13516.6 EFO62150.1 - 6e-07 29.0 8.7 2.2 8.5 0.0 7.2 8 0 0 8 8 8 3 Leucine Rich repeat LRR_8 PF13855.6 EFO62150.1 - 0.0017 18.0 5.7 9.7 6.0 0.1 5.6 6 1 0 6 6 6 1 Leucine rich repeat LRR_4 PF12799.7 EFO62150.1 - 0.12 12.8 12.5 15 6.1 0.2 5.6 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFO62150.1 - 0.28 11.9 11.8 53 4.9 0.1 6.3 5 2 1 6 6 6 0 Leucine Rich Repeat Proteasome PF00227.26 EFO62152.1 - 6.7e-40 136.6 0.0 8.4e-40 136.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFO62152.1 - 1.9e-09 37.0 0.1 3.3e-09 36.3 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature LRR_9 PF14580.6 EFO62153.1 - 2.8e-12 46.5 0.5 4.6e-12 45.8 0.5 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EFO62153.1 - 3.8e-11 43.0 6.9 8.9e-05 22.8 0.0 3.5 1 1 4 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO62153.1 - 1.5e-06 27.9 2.9 3.6e-05 23.4 0.6 3.0 1 1 2 3 3 3 2 Leucine rich repeat RNA_pol_A_bac PF01000.26 EFO62154.1 - 1.4e-18 67.3 0.0 4.5e-18 65.7 0.0 1.8 2 1 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EFO62154.1 - 2.8e-14 52.3 0.0 1.3e-13 50.1 0.0 2.0 1 1 0 2 2 2 1 RNA polymerase Rpb3/Rpb11 dimerisation domain CotE PF10628.9 EFO62154.1 - 0.054 13.1 0.1 1.4 8.5 0.1 2.2 2 0 0 2 2 2 0 Outer spore coat protein E (CotE) Fer4_9 PF13187.6 EFO62154.1 - 1.1 9.4 6.5 0.69 10.1 2.2 2.6 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4 PF00037.27 EFO62154.1 - 6.2 6.8 7.6 0.4 10.6 1.0 2.5 3 0 0 3 3 3 0 4Fe-4S binding domain Cpn60_TCP1 PF00118.24 EFO62155.1 - 1.9e-157 524.8 3.0 2.2e-157 524.6 3.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family UCH PF00443.29 EFO62156.1 - 1.5e-41 142.6 0.0 3.4e-41 141.5 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFO62156.1 - 1.5e-07 31.3 1.3 0.00096 18.8 0.1 2.8 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DAO PF01266.24 EFO62157.1 - 4.3e-57 194.3 6.6 2.9e-56 191.6 0.1 3.6 3 1 1 4 4 4 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFO62157.1 - 6.1e-24 84.8 0.7 5.9e-18 65.1 0.0 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Fer2_BFD PF04324.15 EFO62157.1 - 4.6e-12 46.1 3.9 4.6e-12 46.1 3.9 2.1 2 0 0 2 2 2 1 BFD-like [2Fe-2S] binding domain FAD_binding_2 PF00890.24 EFO62157.1 - 1.6e-07 30.8 9.8 0.00019 20.6 1.0 3.5 3 1 0 3 3 3 2 FAD binding domain HI0933_like PF03486.14 EFO62157.1 - 6.1e-07 28.5 1.9 0.064 12.0 0.2 3.4 3 0 0 3 3 3 3 HI0933-like protein NAD_binding_8 PF13450.6 EFO62157.1 - 1.5e-06 28.3 5.1 0.045 14.0 0.5 3.5 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EFO62157.1 - 2.4e-06 27.2 6.9 0.02 14.3 0.3 3.6 3 1 1 4 4 4 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EFO62157.1 - 7e-06 25.5 4.2 0.25 10.6 0.2 4.2 3 1 1 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFO62157.1 - 1.8e-05 24.1 4.0 0.57 9.4 0.1 4.1 4 0 0 4 4 4 2 Thi4 family DUF1667 PF07892.11 EFO62157.1 - 5e-05 23.3 0.1 0.00012 22.1 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1667) Pyr_redox PF00070.27 EFO62157.1 - 0.00022 21.7 2.2 0.88 10.2 0.0 4.6 5 0 0 5 5 5 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EFO62157.1 - 0.00028 20.1 10.4 0.0053 15.9 0.7 3.9 4 0 0 4 4 4 1 Glucose inhibited division protein A SO_alpha_A3 PF17806.1 EFO62157.1 - 0.00095 19.5 0.0 0.0026 18.1 0.0 1.7 1 0 0 1 1 1 1 Sarcosine oxidase A3 domain Lycopene_cycl PF05834.12 EFO62157.1 - 0.0051 15.9 1.4 2.7 6.9 0.0 3.1 3 0 0 3 3 3 2 Lycopene cyclase protein K_oxygenase PF13434.6 EFO62157.1 - 0.028 13.6 0.1 44 3.1 0.0 3.7 4 0 0 4 4 4 0 L-lysine 6-monooxygenase (NADPH-requiring) AlaDh_PNT_C PF01262.21 EFO62157.1 - 0.032 13.5 1.2 10 5.3 0.1 3.2 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain Ank_2 PF12796.7 EFO62158.1 - 8.8e-107 349.9 26.8 3.6e-14 53.1 0.2 10.8 2 2 7 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62158.1 - 1.3e-62 207.4 22.4 2.4e-07 31.2 0.0 13.3 8 4 7 15 15 15 14 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62158.1 - 7.4e-57 188.7 29.3 1.7e-06 28.2 0.0 16.8 4 4 11 17 17 17 14 Ankyrin repeats (many copies) Ank PF00023.30 EFO62158.1 - 1.3e-45 151.9 22.5 0.065 13.7 0.1 19.5 20 1 0 20 20 20 14 Ankyrin repeat Ank_3 PF13606.6 EFO62158.1 - 4.9e-43 140.2 27.6 0.095 13.3 0.0 19.7 22 0 0 22 22 22 13 Ankyrin repeat Sld5 PF05916.11 EFO62159.1 - 0.057 13.9 0.0 0.095 13.2 0.0 1.4 1 0 0 1 1 1 0 GINS complex protein Rep_fac_C PF08542.11 EFO62161.1 - 7.3e-14 52.0 0.1 1.7e-13 50.8 0.1 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EFO62161.1 - 6.4e-11 42.3 0.1 2.8e-10 40.2 0.0 2.0 2 1 0 2 2 2 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 EFO62161.1 - 0.0038 17.6 2.0 0.22 11.9 0.2 3.1 2 2 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFO62161.1 - 0.037 14.3 0.7 0.2 11.9 0.1 2.4 2 2 0 2 2 2 0 AAA domain AAA PF00004.29 EFO62161.1 - 0.05 14.0 0.0 0.18 12.2 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) HSP90 PF00183.18 EFO62162.1 - 3e-50 171.6 14.4 4.2e-50 171.1 14.4 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EFO62162.1 - 5.9e-13 49.3 0.0 1.1e-12 48.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EFO62162.1 - 1e-10 41.6 0.0 1e-10 41.6 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase NPR3 PF03666.13 EFO62162.1 - 0.0049 15.7 3.8 0.0072 15.2 3.8 1.2 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 RNA_polI_A34 PF08208.11 EFO62162.1 - 0.036 14.2 13.2 0.052 13.6 13.2 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 MDM10 PF12519.8 EFO62162.1 - 1.8 7.3 3.2 2.4 6.9 3.2 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Connexin PF00029.19 EFO62162.1 - 1.9 8.2 7.2 3.5 7.3 7.2 1.3 1 0 0 1 1 1 0 Connexin PTPRCAP PF15713.5 EFO62162.1 - 2.2 8.5 10.5 3.4 8.0 10.5 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RNA_pol_Rpc4 PF05132.14 EFO62162.1 - 2.8 8.4 6.1 4.6 7.7 6.1 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 V_ATPase_I PF01496.19 EFO62162.1 - 3 5.6 6.8 4.4 5.1 6.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 EFO62162.1 - 4.2 5.6 11.4 5.6 5.1 11.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Hexapep PF00132.24 EFO62163.1 - 1.5e-07 30.8 10.1 7.4e-06 25.5 5.9 3.2 2 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 EFO62163.1 - 0.00038 18.7 0.7 0.00062 18.0 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 EFO62163.1 - 0.0057 15.6 1.8 0.011 14.7 0.3 2.1 3 0 0 3 3 3 1 L-fucokinase Pentapeptide_3 PF13576.6 EFO62163.1 - 0.044 13.9 0.0 0.097 12.8 0.0 1.5 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) MHB PF16525.5 EFO62163.1 - 0.06 13.6 0.1 11 6.4 0.1 2.8 2 0 0 2 2 2 0 Haemophore, haem-binding Rcd1 PF04078.13 EFO62164.1 - 5.7e-06 25.8 0.0 1.2e-05 24.7 0.0 1.5 1 1 0 1 1 1 1 Cell differentiation family, Rcd1-like DRIM PF07539.12 EFO62164.1 - 0.083 11.2 0.4 0.13 10.5 0.4 1.4 1 1 0 1 1 1 0 Down-regulated in metastasis RICTOR_V PF14668.6 EFO62164.1 - 0.1 12.9 0.0 4.9 7.5 0.0 2.5 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 PRORP PF16953.5 EFO62165.1 - 0.03 13.9 0.1 0.032 13.8 0.1 1.1 1 0 0 1 1 1 0 Protein-only RNase P Prp19 PF08606.11 EFO62165.1 - 0.037 14.0 2.0 0.085 12.9 0.2 2.2 2 0 0 2 2 2 0 Prp19/Pso4-like Mce4_CUP1 PF11887.8 EFO62165.1 - 0.15 11.5 1.8 0.18 11.2 1.8 1.1 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative UPF0047 PF01894.17 EFO62166.1 - 2e-35 121.4 0.0 2.4e-35 121.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 TPR_11 PF13414.6 EFO62167.1 - 0.011 15.4 0.0 6.1 6.6 0.0 3.5 3 0 0 3 3 3 0 TPR repeat TPR_17 PF13431.6 EFO62167.1 - 0.15 12.5 0.1 7.6 7.2 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat NTF2 PF02136.20 EFO62169.1 - 7.3e-16 58.8 0.0 8.1e-16 58.7 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain SnoaL_2 PF12680.7 EFO62169.1 - 0.032 14.9 0.0 0.033 14.8 0.0 1.1 1 0 0 1 1 1 0 SnoaL-like domain Ank_2 PF12796.7 EFO62170.1 - 3.5e-39 133.3 0.8 3.7e-13 49.9 0.1 4.7 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62170.1 - 1e-24 86.6 3.5 1.5e-07 31.8 0.2 6.2 3 1 2 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO62170.1 - 6.4e-22 77.0 0.0 0.0011 19.3 0.0 8.1 5 2 3 8 8 8 4 Ankyrin repeat Ank_3 PF13606.6 EFO62170.1 - 6.2e-19 66.1 2.6 0.00056 20.1 0.0 7.8 8 1 1 9 9 9 4 Ankyrin repeat Ank_5 PF13857.6 EFO62170.1 - 1.8e-18 66.4 10.4 1e-06 28.9 0.2 6.5 2 2 5 7 7 7 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFO62171.1 - 1.4e-37 128.1 7.3 9e-09 35.8 0.0 5.9 3 2 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62171.1 - 2.3e-25 88.3 7.2 2.3e-05 24.6 0.0 7.9 6 2 3 9 9 9 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62171.1 - 8.4e-25 84.1 4.0 0.21 12.3 0.0 10.0 10 0 0 10 10 10 6 Ankyrin repeat Ank_4 PF13637.6 EFO62171.1 - 2.4e-22 79.0 3.9 0.0018 18.8 0.0 7.2 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO62171.1 - 1.3e-21 76.0 3.4 0.091 13.2 0.0 8.6 8 0 0 8 8 8 7 Ankyrin repeat YchF-GTPase_C PF06071.13 EFO62172.1 - 1.6e-35 121.2 0.2 3e-35 120.3 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EFO62172.1 - 1.8e-19 69.9 0.0 7.2e-19 68.0 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFO62172.1 - 3.6e-05 23.3 0.0 0.00019 21.0 0.0 2.2 2 1 1 3 3 3 1 Ferrous iron transport protein B Transglut_core PF01841.19 EFO62175.1 - 0.00012 22.5 0.0 0.0015 19.0 0.0 2.4 2 0 0 2 2 2 1 Transglutaminase-like superfamily Prefoldin PF02996.17 EFO62176.1 - 1.9e-19 69.8 0.1 2.7e-19 69.3 0.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit NECFESHC PF16621.5 EFO62176.1 - 0.036 14.0 0.3 0.061 13.3 0.3 1.4 1 0 0 1 1 1 0 SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1 Pkinase PF00069.25 EFO62177.1 - 6.8e-62 209.2 0.0 9.6e-62 208.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62177.1 - 9.5e-36 123.4 0.0 1.5e-35 122.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFO62177.1 - 1.3e-05 24.7 0.0 2.2e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFO62177.1 - 0.00046 19.1 0.0 0.0005 19.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFO62177.1 - 0.00052 19.4 0.1 0.31 10.3 0.0 2.6 3 0 0 3 3 3 2 Kinase-like Nop PF01798.18 EFO62178.1 - 1.2e-69 234.3 0.8 2.8e-69 233.1 0.8 1.6 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EFO62178.1 - 3e-12 46.7 0.2 3e-12 46.7 0.2 2.6 2 1 0 2 2 2 1 NOP5NT (NUC127) domain FtsJ PF01728.19 EFO62181.1 - 1.7e-53 181.4 0.0 6.4e-53 179.5 0.0 2.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Spb1_C PF07780.12 EFO62181.1 - 1.4e-48 165.4 15.0 1.4e-48 165.4 15.0 3.4 4 0 0 4 4 4 1 Spb1 C-terminal domain DUF3381 PF11861.8 EFO62181.1 - 8.9e-24 84.1 0.1 8.9e-24 84.1 0.1 4.7 5 1 1 6 6 6 1 Domain of unknown function (DUF3381) LRR_6 PF13516.6 EFO62182.1 - 8.2e-10 37.9 25.0 0.35 11.0 0.1 8.2 8 0 0 8 8 8 7 Leucine Rich repeat LRR_4 PF12799.7 EFO62182.1 - 0.0071 16.7 20.5 0.21 12.1 0.3 6.3 6 0 0 6 6 6 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO62182.1 - 3 7.7 21.4 0.89 9.4 5.4 5.3 4 1 1 5 5 5 0 Leucine rich repeat TCTP PF00838.17 EFO62183.1 - 1e-35 123.5 8.9 7.1e-35 120.8 8.9 1.8 1 1 0 1 1 1 1 Translationally controlled tumour protein WW PF00397.26 EFO62184.1 - 2.7e-08 33.7 1.7 5.6e-08 32.7 1.7 1.6 1 0 0 1 1 1 1 WW domain AIP3 PF03915.13 EFO62184.1 - 0.0027 16.9 8.7 0.0056 15.8 8.7 1.4 1 0 0 1 1 1 1 Actin interacting protein 3 Gp58 PF07902.11 EFO62184.1 - 0.0055 15.1 5.1 0.0088 14.4 5.1 1.2 1 0 0 1 1 1 1 gp58-like protein Sds3 PF08598.11 EFO62184.1 - 0.12 12.4 20.9 0.01 15.9 7.6 3.1 1 1 2 3 3 3 0 Sds3-like RRF PF01765.19 EFO62184.1 - 0.14 12.1 8.8 0.19 11.7 5.2 2.7 1 1 1 2 2 2 0 Ribosome recycling factor Head_binding PF09008.10 EFO62184.1 - 0.14 12.4 0.1 0.38 11.0 0.1 1.6 1 0 0 1 1 1 0 Head binding DUF3826 PF12875.7 EFO62184.1 - 0.21 11.7 7.7 0.68 10.0 7.7 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3826) Seryl_tRNA_N PF02403.22 EFO62184.1 - 0.51 10.6 20.3 0.088 13.0 2.0 3.8 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain IMD PF08397.11 EFO62184.1 - 0.54 9.6 9.7 1.5 8.2 9.7 1.7 1 0 0 1 1 1 0 IRSp53/MIM homology domain GCN5L1 PF06320.13 EFO62184.1 - 1.6 8.9 15.4 0.078 13.1 2.1 3.2 2 1 1 3 3 3 0 GCN5-like protein 1 (GCN5L1) Enkurin PF13864.6 EFO62185.1 - 3.5e-18 65.9 5.0 5.4e-18 65.2 5.0 1.3 1 0 0 1 1 1 1 Calmodulin-binding HlyD_D23 PF16576.5 EFO62185.1 - 0.12 11.6 0.7 0.18 11.0 0.7 1.2 1 0 0 1 1 1 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion P4Ha_N PF08336.11 EFO62185.1 - 0.2 11.7 1.9 0.34 10.9 1.9 1.4 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Acetyltransf_1 PF00583.25 EFO62187.1 - 1.3e-05 25.4 0.0 2.7e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFO62187.1 - 0.0011 19.0 0.1 0.0042 17.0 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Bromodomain PF00439.25 EFO62187.1 - 0.014 15.5 0.0 0.14 12.3 0.0 2.5 2 1 0 2 2 2 0 Bromodomain Ribosomal_S19 PF00203.21 EFO62188.1 - 3.4e-27 94.1 0.2 6e-27 93.3 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S19 Peptidase_C97 PF05903.14 EFO62189.1 - 4.4e-41 140.2 0.2 6.4e-41 139.7 0.2 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 EFO62189.1 - 0.013 15.8 0.1 0.027 14.8 0.1 1.5 1 0 0 1 1 1 0 Lecithin retinol acyltransferase NAPRTase_N PF17767.1 EFO62189.1 - 0.029 14.7 0.0 0.06 13.7 0.0 1.5 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain DUF4796 PF16044.5 EFO62189.1 - 0.032 13.8 0.0 0.055 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4796) PA28_beta PF02252.18 EFO62189.1 - 0.045 13.4 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 Proteasome activator pa28 beta subunit ThiF PF00899.21 EFO62190.1 - 5.3e-74 248.6 0.0 7.1e-54 182.7 0.0 2.5 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EFO62190.1 - 1.3e-51 176.0 0.1 1.7e-51 175.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 EFO62190.1 - 1e-08 35.8 0.0 2.5e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin fold domain Shikimate_DH PF01488.20 EFO62190.1 - 0.022 14.8 0.0 0.88 9.6 0.0 2.7 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase E1_4HB PF16191.5 EFO62190.1 - 0.028 14.6 0.0 0.071 13.3 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin-activating enzyme E1 four-helix bundle N_formyltrans_C PF18216.1 EFO62190.1 - 0.048 13.4 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 N-formyltransferase dimerization C-terminal domain VSP PF03302.13 EFO62191.1 - 3.5e-86 289.5 171.0 1.8e-45 155.5 29.6 5.2 1 1 4 5 5 5 4 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO62191.1 - 0.0027 17.8 0.9 0.0089 16.1 0.9 1.9 1 0 0 1 1 1 1 Podoplanin VSP PF03302.13 EFO62192.1 - 2.9e-28 98.8 120.5 1.2e-25 90.2 38.1 4.9 1 1 3 4 4 4 3 Giardia variant-specific surface protein VSP PF03302.13 EFO62193.1 - 4.2e-90 302.5 104.9 5.2e-50 170.4 23.5 4.0 1 1 3 4 4 4 4 Giardia variant-specific surface protein Reprolysin_3 PF13582.6 EFO62194.1 - 0.031 14.8 1.2 0.13 12.8 0.6 2.3 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Ephrin_rec_like PF07699.13 EFO62194.1 - 0.037 13.8 46.1 0.14 11.9 4.5 7.2 5 2 2 7 7 7 0 Putative ephrin-receptor like LRR_8 PF13855.6 EFO62195.1 - 6.9e-10 38.5 25.3 1.4e-05 24.7 5.2 4.5 2 1 5 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 EFO62195.1 - 8.6e-09 35.6 23.9 0.0027 18.1 1.1 5.4 1 1 6 7 7 7 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFO62195.1 - 0.0015 18.1 2.7 0.0015 18.1 2.7 3.0 2 1 1 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 EFO62195.1 - 0.82 10.5 14.9 31 5.7 0.5 6.6 4 1 0 4 4 4 0 Leucine Rich Repeat Proteasome PF00227.26 EFO62196.1 - 1.5e-48 164.8 0.0 1.9e-48 164.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFO62196.1 - 1.1e-10 40.9 0.0 2.2e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF1853 PF08907.11 EFO62198.1 - 0.07 12.8 0.3 0.074 12.7 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1853) TTL PF03133.15 EFO62199.1 - 3.4e-87 292.3 0.1 4.4e-87 291.9 0.1 1.0 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EFO62199.1 - 6.3e-07 28.9 0.0 0.00086 18.6 0.0 2.4 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EFO62199.1 - 1.8e-05 24.1 0.0 0.014 14.7 0.0 2.2 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp RimK PF08443.11 EFO62199.1 - 0.19 11.3 0.0 2.1 7.9 0.0 2.0 2 0 0 2 2 2 0 RimK-like ATP-grasp domain Topoisom_bac PF01131.20 EFO62200.1 - 3.1e-55 187.9 0.0 3.5e-39 135.0 0.0 2.7 2 1 0 2 2 2 2 DNA topoisomerase Toprim PF01751.22 EFO62200.1 - 1.1e-12 48.0 0.0 4.4e-12 46.1 0.0 2.0 2 0 0 2 2 2 1 Toprim domain Ank_2 PF12796.7 EFO62201.1 - 4.4e-37 126.5 9.9 1.2e-09 38.6 0.7 5.6 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62201.1 - 5.5e-18 65.1 3.8 6.1e-05 23.5 0.0 5.5 5 1 0 5 5 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62201.1 - 1.8e-14 52.4 7.3 0.15 12.7 0.0 8.3 8 0 0 8 8 8 4 Ankyrin repeat Ank PF00023.30 EFO62201.1 - 3.9e-14 52.4 11.8 0.0062 16.9 0.1 7.9 7 1 1 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 EFO62201.1 - 5.7e-14 52.0 12.4 0.05 13.9 0.1 7.1 3 2 4 7 7 7 5 Ankyrin repeats (many copies) QueH PF02677.14 EFO62201.1 - 0.0072 16.4 3.1 0.018 15.1 2.3 2.1 2 0 0 2 2 2 1 Epoxyqueuosine reductase QueH KASH_CCD PF14662.6 EFO62201.1 - 0.043 13.6 34.1 0.044 13.6 23.2 3.4 3 1 0 4 4 4 0 Coiled-coil region of CCDC155 or KASH DUF2353 PF09789.9 EFO62201.1 - 0.15 11.4 26.2 1.6 8.0 2.3 2.5 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) AATF-Che1 PF13339.6 EFO62201.1 - 1.7 9.3 22.2 0.26 12.0 12.0 3.3 1 1 1 2 2 1 0 Apoptosis antagonizing transcription factor APG6_N PF17675.1 EFO62201.1 - 5.6 7.5 31.1 17 5.9 0.2 3.3 2 1 0 2 2 2 0 Apg6 coiled-coil region DUF3450 PF11932.8 EFO62201.1 - 6.4 6.0 26.9 2.6 7.3 7.8 4.4 3 1 1 4 4 4 0 Protein of unknown function (DUF3450) Fez1 PF06818.15 EFO62201.1 - 9.6 6.6 25.9 2.3 8.6 8.8 2.9 1 1 1 2 2 2 0 Fez1 Ank_2 PF12796.7 EFO62202.1 - 1e-73 243.9 29.2 3.2e-13 50.1 1.3 8.3 2 2 5 8 8 8 8 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO62202.1 - 4.1e-41 134.3 27.5 0.0023 18.3 0.1 15.0 15 0 0 15 15 15 11 Ankyrin repeat Ank_4 PF13637.6 EFO62202.1 - 5.5e-40 135.2 21.2 1.5e-06 28.7 0.0 11.0 6 4 8 14 14 14 12 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62202.1 - 1.9e-36 123.6 36.2 0.0017 18.6 0.1 13.7 2 2 11 14 14 14 12 Ankyrin repeats (many copies) Ank PF00023.30 EFO62202.1 - 2.1e-34 116.4 29.4 0.0087 16.5 0.2 13.4 12 2 2 14 14 14 11 Ankyrin repeat Ank_2 PF12796.7 EFO62203.1 - 1.7e-62 208.0 8.5 1.1e-15 58.0 0.1 6.2 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62203.1 - 1.2e-36 124.3 7.5 9.4e-07 29.0 0.0 8.9 2 2 7 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62203.1 - 1.6e-36 120.2 2.6 0.0027 18.1 0.1 10.3 10 0 0 10 10 10 8 Ankyrin repeat Ank PF00023.30 EFO62203.1 - 4.8e-36 121.7 2.9 0.00057 20.2 0.1 10.1 9 1 1 10 10 10 7 Ankyrin repeat Ank_4 PF13637.6 EFO62203.1 - 1.4e-32 111.6 5.8 3e-06 27.7 0.0 8.5 7 2 3 10 10 10 7 Ankyrin repeats (many copies) Chordopox_A20R PF05941.13 EFO62203.1 - 0.0034 16.4 0.1 0.0054 15.8 0.1 1.3 1 0 0 1 1 1 1 Chordopoxvirus A20R protein Homez PF11569.8 EFO62203.1 - 0.074 12.5 0.0 1.8 8.1 0.0 2.5 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez EIAV_GP90 PF00971.18 EFO62204.1 - 0.074 11.7 0.3 0.13 10.9 0.1 1.4 1 1 0 1 1 1 0 EIAV coat protein, gp90 DUF4821 PF16092.5 EFO62205.1 - 5.1e-23 82.0 0.0 9.8e-20 71.3 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4821) RRN3 PF05327.11 EFO62205.1 - 0.033 12.8 4.5 0.057 12.0 4.5 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 EFO62205.1 - 0.13 10.6 1.2 0.19 10.0 1.2 1.2 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 EFO62205.1 - 0.67 8.0 17.4 0.18 9.9 13.8 1.8 2 0 0 2 2 2 0 DNA polymerase phi Sigma70_ner PF04546.13 EFO62205.1 - 3.5 7.5 13.1 0.088 12.7 6.0 1.9 2 0 0 2 2 2 0 Sigma-70, non-essential region DUF1043 PF06295.12 EFO62206.1 - 0.073 13.1 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Ribosomal_S24e PF01282.19 EFO62207.1 - 1.5e-23 82.5 0.4 2.3e-23 81.9 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein S24e KASH_CCD PF14662.6 EFO62208.1 - 0.049 13.4 0.1 0.092 12.6 0.1 1.4 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Ank_2 PF12796.7 EFO62209.1 - 2.9e-35 120.7 5.3 5.8e-13 49.2 0.2 5.5 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62209.1 - 2.8e-18 65.8 7.5 0.001 19.3 0.1 8.0 4 2 4 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62209.1 - 1.5e-17 61.9 6.4 0.21 12.2 0.0 8.7 8 0 0 8 8 8 4 Ankyrin repeat Ank_4 PF13637.6 EFO62209.1 - 1.8e-16 60.3 1.0 2.2e-06 28.1 0.0 5.8 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO62209.1 - 9.2e-15 54.3 7.7 0.059 13.8 0.0 8.0 7 1 0 7 7 7 4 Ankyrin repeat OmpH PF03938.14 EFO62209.1 - 0.0016 18.8 8.2 0.0031 17.9 8.2 1.4 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) KASH_CCD PF14662.6 EFO62209.1 - 0.015 15.2 16.3 0.029 14.2 16.3 1.5 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH GAS PF13851.6 EFO62209.1 - 0.018 14.4 19.9 0.074 12.4 10.2 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Leu_zip PF15294.6 EFO62209.1 - 0.031 13.8 15.2 0.011 15.3 11.6 1.8 1 1 1 2 2 2 0 Leucine zipper HAP1_N PF04849.13 EFO62209.1 - 0.32 10.2 18.8 1.3 8.2 18.8 1.9 1 1 0 1 1 1 0 HAP1 N-terminal conserved region Tho2 PF11262.8 EFO62209.1 - 0.32 10.1 5.8 0.64 9.2 5.8 1.5 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF5082 PF16888.5 EFO62209.1 - 0.33 11.2 9.2 0.78 10.0 9.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) Exonuc_VII_L PF02601.15 EFO62209.1 - 0.39 10.2 5.7 0.55 9.8 5.7 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.12 EFO62209.1 - 0.45 10.6 4.2 1.2 9.1 4.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Atg14 PF10186.9 EFO62209.1 - 0.56 9.2 16.0 0.4 9.7 13.4 1.8 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Rootletin PF15035.6 EFO62209.1 - 0.65 10.0 19.7 0.67 9.9 16.3 2.1 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion FUSC PF04632.12 EFO62209.1 - 0.96 7.9 7.3 1.5 7.3 7.3 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family FTCD_C PF04961.12 EFO62209.1 - 1.4 8.6 4.0 4.4 7.0 3.3 2.0 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase LMBR1 PF04791.16 EFO62209.1 - 2 7.2 4.8 2.9 6.7 4.8 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein YabA PF06156.13 EFO62209.1 - 2.9 8.6 15.4 21 5.8 5.1 3.0 1 1 2 3 3 3 0 Initiation control protein YabA FapA PF03961.13 EFO62209.1 - 3 6.3 11.1 2.9 6.4 9.8 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A EMP24_GP25L PF01105.24 EFO62209.1 - 4.2 7.3 6.7 2.1 8.2 3.4 2.1 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF4192 PF13830.6 EFO62210.1 - 0.7 9.9 10.1 1.3 9.0 10.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) AAA_28 PF13521.6 EFO62211.1 - 0.0093 16.2 0.1 0.024 14.9 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFO62211.1 - 0.012 16.1 0.6 0.041 14.3 0.6 2.0 1 1 0 1 1 1 0 AAA ATPase domain Dynamin_N PF00350.23 EFO62211.1 - 0.014 15.4 0.3 0.031 14.3 0.3 1.9 1 1 0 1 1 1 0 Dynamin family MMR_HSR1_Xtn PF16897.5 EFO62211.1 - 0.084 12.9 0.3 3.3 7.7 0.0 2.8 3 0 0 3 3 3 0 C-terminal region of MMR_HSR1 domain zf-CHY PF05495.12 EFO62212.1 - 2.1e-13 50.6 10.4 2.1e-13 50.6 10.4 3.9 2 1 0 2 2 2 1 CHY zinc finger zf-RING_4 PF14570.6 EFO62212.1 - 0.015 15.0 2.7 0.015 15.0 2.7 5.6 3 2 3 6 6 6 0 RING/Ubox like zinc-binding domain DUF4808 PF16066.5 EFO62212.1 - 0.1 13.1 0.1 0.43 11.1 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4808) Ank_2 PF12796.7 EFO62213.1 - 5.7e-48 161.4 7.6 8.4e-14 51.9 0.1 6.2 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO62213.1 - 1.8e-27 92.3 5.9 0.017 15.6 0.0 11.0 11 0 0 11 11 11 8 Ankyrin repeat Ank PF00023.30 EFO62213.1 - 2.5e-24 84.6 8.9 0.24 11.9 0.1 11.1 11 0 0 11 11 11 9 Ankyrin repeat Ank_4 PF13637.6 EFO62213.1 - 7.9e-24 83.7 7.4 1.6e-05 25.3 0.2 9.2 8 1 1 9 9 9 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62213.1 - 1.7e-22 79.2 13.4 0.0033 17.7 0.1 9.5 4 3 5 9 9 9 9 Ankyrin repeats (many copies) VSP PF03302.13 EFO62215.1 - 3.1e-71 240.3 108.2 8.5e-37 126.9 30.2 4.0 1 1 3 4 4 4 3 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO62215.1 - 0.12 12.4 0.2 0.34 11.0 0.0 1.8 2 0 0 2 2 2 0 Podoplanin VSP PF03302.13 EFO62216.1 - 3e-43 148.2 183.2 1.2e-31 109.9 69.9 7.0 1 1 4 6 6 6 6 Giardia variant-specific surface protein SKG6 PF08693.10 EFO62216.1 - 0.19 11.1 0.5 0.37 10.2 0.5 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain VSP PF03302.13 EFO62217.1 - 0.00011 21.2 31.8 0.00011 21.2 31.8 6.9 1 1 4 5 5 5 2 Giardia variant-specific surface protein ABC_tran PF00005.27 EFO62218.1 - 1.1e-46 158.7 0.0 1e-23 84.4 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EFO62218.1 - 4.3e-10 39.9 0.0 0.026 14.3 0.0 3.4 3 0 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFO62218.1 - 8.5e-06 25.4 1.6 0.00013 21.6 0.1 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain SMC_N PF02463.19 EFO62218.1 - 0.0027 17.2 0.0 0.53 9.7 0.0 3.0 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 EFO62218.1 - 0.0034 17.1 2.6 1.6 8.4 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_23 PF13476.6 EFO62218.1 - 0.0057 17.2 0.2 0.013 16.0 0.0 1.6 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EFO62218.1 - 0.029 14.3 0.6 2 8.3 0.0 2.8 2 0 0 2 2 2 0 RsgA GTPase MukB PF04310.12 EFO62218.1 - 0.04 13.7 0.1 0.04 13.7 0.1 1.7 2 0 0 2 2 2 0 MukB N-terminal AAA_25 PF13481.6 EFO62218.1 - 0.044 13.3 0.1 9.3 5.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain FYRN PF05964.14 EFO62218.1 - 0.11 12.4 2.0 0.45 10.4 0.1 2.5 2 0 0 2 2 2 0 F/Y-rich N-terminus VSP PF03302.13 EFO62219.1 - 2.6e-91 306.4 162.9 5.1e-46 157.3 22.9 5.4 1 1 5 6 6 6 5 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO62219.1 - 0.038 14.1 0.2 0.1 12.7 0.2 1.7 1 0 0 1 1 1 0 Podoplanin ABC_tran PF00005.27 EFO62220.1 - 1.5e-43 148.6 0.0 4.8e-25 88.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EFO62220.1 - 8e-17 62.0 2.8 6.9e-07 29.4 0.0 4.4 3 1 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EFO62220.1 - 1.1e-07 31.3 71.3 2.2e-05 23.7 24.0 3.6 2 1 1 3 3 2 2 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EFO62220.1 - 2.5e-07 30.8 0.0 0.018 14.9 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EFO62220.1 - 2.1e-05 25.1 1.1 0.008 16.7 0.1 3.1 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 EFO62220.1 - 7.3e-05 22.4 2.8 0.0017 18.1 0.3 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EFO62220.1 - 0.0019 18.2 0.0 0.76 9.9 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase MukB PF04310.12 EFO62220.1 - 0.021 14.6 0.1 0.045 13.5 0.1 1.5 1 0 0 1 1 1 0 MukB N-terminal SMC_N PF02463.19 EFO62220.1 - 0.023 14.1 0.3 6.6 6.1 0.1 3.1 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 EFO62220.1 - 0.15 11.8 0.0 1.1 8.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EFO62220.1 - 0.17 12.1 1.8 1.4 9.1 0.3 2.4 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EFO62220.1 - 0.47 10.5 2.0 3.1 7.8 0.0 2.5 3 0 0 3 3 3 0 Dynamin family adh_short PF00106.25 EFO62221.1 - 1.4e-37 129.0 0.0 1.9e-37 128.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFO62221.1 - 3.1e-23 82.6 0.0 4e-23 82.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFO62221.1 - 8.4e-14 51.9 0.0 1.2e-13 51.4 0.0 1.1 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EFO62221.1 - 7.6e-07 28.8 0.3 3.6e-05 23.3 0.3 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFO62221.1 - 8.6e-07 28.6 0.1 1.8e-06 27.6 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFO62221.1 - 4.1e-05 22.9 0.0 5.4e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Glyco_tran_WecB PF03808.13 EFO62221.1 - 0.0016 18.4 0.0 0.0031 17.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase WecB/TagA/CpsF family Sacchrp_dh_NADP PF03435.18 EFO62221.1 - 0.0048 17.2 0.0 0.0084 16.4 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 EFO62221.1 - 0.0055 16.3 0.0 0.008 15.8 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFO62221.1 - 0.032 14.1 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding 3HCDH_N PF02737.18 EFO62221.1 - 0.032 14.1 0.0 0.05 13.5 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 EFO62221.1 - 0.045 12.8 0.0 0.067 12.3 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain F420_oxidored PF03807.17 EFO62221.1 - 0.049 14.2 0.0 0.086 13.4 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 EFO62221.1 - 0.1 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA betaPIX_CC PF16523.5 EFO62222.1 - 0.14 12.0 7.8 0.076 12.8 1.1 3.4 4 0 0 4 4 4 0 betaPIX coiled coil Ribosomal_L29 PF00831.23 EFO62222.1 - 2.4 8.2 6.8 0.51 10.4 0.8 3.3 2 0 0 2 2 2 0 Ribosomal L29 protein IZUMO PF15005.6 EFO62225.1 - 0.016 15.8 6.9 0.046 14.2 6.9 1.8 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated Ank_2 PF12796.7 EFO62226.1 - 1.6e-39 134.4 11.0 2.1e-08 34.6 0.1 5.2 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62226.1 - 3.1e-20 72.3 2.2 5.5e-05 23.6 0.1 6.6 4 3 2 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62226.1 - 4.1e-20 71.6 5.7 0.0013 18.9 0.1 7.0 3 3 4 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62226.1 - 4e-18 63.6 10.8 0.092 13.4 0.0 8.9 9 0 0 9 9 9 4 Ankyrin repeat Ank PF00023.30 EFO62226.1 - 2.9e-16 59.1 9.1 0.39 11.2 0.0 8.3 9 0 0 9 9 9 5 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO62226.1 - 2.4e-09 36.9 12.7 6.1e-09 35.6 12.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO62226.1 - 0.00017 21.4 10.6 0.00042 20.1 10.6 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFO62226.1 - 0.0066 16.7 9.1 0.021 15.2 9.1 2.0 1 0 0 1 1 1 1 Ring finger domain zf-RanBP PF00641.18 EFO62226.1 - 0.0082 15.4 2.8 0.0082 15.4 2.8 2.2 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others zf-C3HC4_2 PF13923.6 EFO62226.1 - 1.2 9.1 11.5 6.7 6.6 10.7 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFO62226.1 - 3.8 7.5 15.5 1.3 9.1 12.2 2.0 2 0 0 2 2 2 0 zinc-RING finger domain DEAD PF00270.29 EFO62227.1 - 1.7e-25 89.8 0.5 1e-22 80.8 0.1 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO62227.1 - 1.7e-22 79.9 0.3 5.4e-22 78.2 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFO62227.1 - 2.1e-11 44.1 1.5 3.7e-11 43.3 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EFO62227.1 - 1.4e-05 24.0 0.0 2.9e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain AAA_30 PF13604.6 EFO62227.1 - 0.00012 21.9 0.0 0.0003 20.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFO62227.1 - 0.0012 19.1 0.4 0.025 14.8 0.1 2.8 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EFO62227.1 - 0.0025 18.2 0.3 0.017 15.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_lid_1 PF17857.1 EFO62227.1 - 0.24 11.7 2.4 0.46 10.7 0.8 2.2 2 0 0 2 2 2 0 AAA+ lid domain DUF771 PF05595.11 EFO62228.1 - 0.1 12.6 0.3 0.3 11.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF771) PIN_6 PF17146.4 EFO62228.1 - 5.8 7.5 7.2 14 6.2 0.1 3.8 3 1 0 3 3 3 0 PIN domain of ribonuclease Ank_2 PF12796.7 EFO62229.1 - 4.1e-45 152.3 12.1 2.8e-10 40.7 0.0 6.4 2 2 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62229.1 - 2.1e-26 91.7 12.7 0.00021 21.5 0.1 9.4 4 3 6 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62229.1 - 5.9e-23 78.5 11.5 0.08 13.5 0.0 10.6 11 0 0 11 11 11 7 Ankyrin repeat Ank_4 PF13637.6 EFO62229.1 - 1.1e-22 80.1 6.4 0.0021 18.6 0.0 8.6 5 3 4 9 9 9 9 Ankyrin repeats (many copies) Ank PF00023.30 EFO62229.1 - 5.6e-18 64.5 16.6 0.043 14.3 0.9 10.6 8 2 2 10 10 10 7 Ankyrin repeat VSP PF03302.13 EFO62230.1 - 4.8e-93 312.1 150.7 4.5e-50 170.7 25.0 6.9 1 1 4 5 5 5 5 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO62230.1 - 0.035 14.2 0.3 0.035 14.2 0.3 2.5 2 0 0 2 2 2 0 Podoplanin zf-rbx1 PF12678.7 EFO62231.1 - 5e-16 58.7 16.6 5.9e-16 58.5 16.6 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EFO62231.1 - 7.2e-14 51.6 8.4 8.1e-14 51.5 8.4 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EFO62231.1 - 1.2e-07 31.9 19.0 1.6e-06 28.3 19.2 2.1 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFO62231.1 - 1.4e-07 31.2 11.5 1.4e-07 31.2 11.5 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFO62231.1 - 0.0011 18.7 3.2 0.0011 18.7 3.2 2.5 3 1 0 3 3 3 1 RING-like zinc finger TackOD1 PF18551.1 EFO62231.1 - 0.0011 18.6 7.8 0.0013 18.5 7.8 1.0 1 0 0 1 1 1 1 Thaumarchaeal output domain 1 zf-C3HC4 PF00097.25 EFO62231.1 - 0.0022 17.8 17.8 0.022 14.6 17.9 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFO62231.1 - 0.003 17.5 11.4 0.0048 16.9 10.5 1.9 1 1 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 EFO62231.1 - 0.0079 15.8 17.1 0.31 10.7 17.1 2.2 1 1 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 EFO62231.1 - 0.014 15.3 17.7 0.57 10.2 17.9 2.5 1 1 1 2 2 2 0 zinc-RING finger domain zf-C3H2C3 PF17122.5 EFO62231.1 - 0.018 15.1 5.3 0.018 15.1 5.3 2.8 2 2 0 2 2 2 0 Zinc-finger C1_1 PF00130.22 EFO62231.1 - 0.029 14.3 3.3 0.029 14.3 3.3 2.6 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-Nse PF11789.8 EFO62231.1 - 0.44 10.4 9.0 0.86 9.5 9.0 1.6 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Rtf2 PF04641.12 EFO62231.1 - 0.53 9.6 4.3 0.41 10.0 3.5 1.3 1 1 0 1 1 1 0 Rtf2 RING-finger FANCL_C PF11793.8 EFO62231.1 - 1.8 8.8 15.0 25 5.2 15.0 2.6 1 1 0 1 1 1 0 FANCL C-terminal domain LRR_4 PF12799.7 EFO62232.1 - 6.2e-12 45.5 3.6 1.2e-05 25.5 0.1 3.2 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO62232.1 - 4.4e-08 32.8 7.1 0.00051 19.7 0.2 2.7 1 1 0 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 EFO62232.1 - 7.4e-05 22.8 6.3 19 6.3 0.1 5.5 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_9 PF14580.6 EFO62232.1 - 0.0058 16.1 3.0 0.0071 15.9 0.9 2.2 2 0 0 2 2 2 1 Leucine-rich repeat ToxN_toxin PF13958.6 EFO62232.1 - 0.018 15.3 0.8 0.077 13.2 0.1 2.4 2 0 0 2 2 2 0 Toxin ToxN, type III toxin-antitoxin system LRR_6 PF13516.6 EFO62232.1 - 1.6 9.0 8.9 16 5.8 0.0 4.3 4 0 0 4 4 4 0 Leucine Rich repeat HR1 PF02185.16 EFO62233.1 - 0.017 15.3 6.1 0.017 15.3 6.1 2.0 2 0 0 2 2 2 0 Hr1 repeat Peptidase_A22B PF04258.13 EFO62234.1 - 2.4e-46 158.5 22.0 3.4e-46 158.0 22.0 1.1 1 0 0 1 1 1 1 Signal peptide peptidase DUF4131 PF13567.6 EFO62234.1 - 8.4 6.0 0.0 8.4 6.0 0.0 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4131) Ank_2 PF12796.7 EFO62235.1 - 2.5e-35 120.9 6.6 6.7e-12 45.8 0.6 3.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO62235.1 - 5.2e-27 94.9 0.0 1.4e-26 93.5 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Ank PF00023.30 EFO62235.1 - 3e-25 87.5 7.2 1.8e-05 24.9 0.1 6.6 5 1 1 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 EFO62235.1 - 3.1e-22 76.2 5.7 0.00071 19.8 0.1 6.9 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 EFO62235.1 - 3.5e-20 72.1 8.1 4.2e-08 33.6 0.5 4.7 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62235.1 - 8.2e-20 70.6 9.9 0.00042 20.5 0.3 6.5 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO62235.1 - 1.6e-15 57.1 0.0 3.7e-15 55.9 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase ABATE PF07336.11 EFO62235.1 - 0.00092 19.9 0.1 0.0022 18.7 0.1 1.7 1 0 0 1 1 1 1 Putative stress-induced transcription regulator zf-RING_4 PF14570.6 EFO62236.1 - 5e-12 45.4 15.1 1.2e-11 44.2 15.1 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 EFO62236.1 - 6.3e-05 22.7 0.0 0.00011 21.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Prok-RING_4 PF14447.6 EFO62236.1 - 0.013 15.3 13.4 0.27 11.1 5.4 2.6 1 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-UDP PF14569.6 EFO62236.1 - 0.79 9.9 7.7 1.8 8.7 7.7 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-RING_2 PF13639.6 EFO62236.1 - 6.1 7.3 20.5 0.23 11.8 14.2 1.9 2 0 0 2 2 2 0 Ring finger domain Radial_spoke PF04712.12 EFO62237.1 - 1.3e-28 100.2 50.3 4e-17 62.3 22.7 5.9 2 2 0 2 2 2 2 Radial spokehead-like protein Nop25 PF09805.9 EFO62237.1 - 0.00025 21.5 5.4 0.00025 21.5 5.4 5.4 6 1 0 6 6 6 1 Nucleolar protein 12 (25kDa) Med22 PF06179.12 EFO62237.1 - 0.19 12.0 0.0 0.19 12.0 0.0 2.9 3 0 0 3 3 3 0 Surfeit locus protein 5 subunit 22 of Mediator complex tRNA_U5-meth_tr PF05958.11 EFO62238.1 - 3e-08 33.0 0.1 6.6e-08 31.9 0.1 1.5 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 EFO62238.1 - 0.00053 19.8 0.1 0.001 18.9 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFO62238.1 - 0.011 15.3 0.0 0.021 14.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_25 PF13649.6 EFO62238.1 - 0.031 15.0 0.0 0.083 13.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 EFO62238.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Enkurin PF13864.6 EFO62239.1 - 3.1e-16 59.6 5.6 3.1e-16 59.6 5.6 3.1 3 1 0 3 3 3 1 Calmodulin-binding Jnk-SapK_ap_N PF09744.9 EFO62240.1 - 0.0073 16.5 3.2 0.0096 16.1 3.2 1.2 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 Matrix PF00661.21 EFO62240.1 - 0.015 14.0 0.4 0.12 11.1 0.3 1.9 2 0 0 2 2 2 0 Viral matrix protein DivIC PF04977.15 EFO62240.1 - 0.052 13.3 1.6 0.075 12.8 1.3 1.6 2 0 0 2 2 2 0 Septum formation initiator DUF1811 PF08838.10 EFO62240.1 - 0.19 12.0 1.2 0.31 11.3 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1811) Antistasin PF02822.14 EFO62241.1 - 0.05 14.2 1.7 1.5 9.5 0.1 2.5 2 0 0 2 2 2 0 Antistasin family HEAT_2 PF13646.6 EFO62241.1 - 0.14 12.6 0.5 0.41 11.1 0.5 1.8 1 0 0 1 1 1 0 HEAT repeats Pkinase PF00069.25 EFO62242.1 - 6.8e-40 137.1 0.0 1e-39 136.5 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62242.1 - 2.2e-16 60.0 0.0 1.6e-15 57.1 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO62242.1 - 0.00018 21.0 0.0 0.00096 18.5 0.0 2.2 2 1 0 2 2 2 1 Kinase-like XPG_N PF00752.17 EFO62244.1 - 4.7e-27 94.4 0.0 9.1e-27 93.5 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EFO62244.1 - 1e-25 89.9 0.1 1e-25 89.9 0.1 2.1 3 0 0 3 3 3 1 XPG I-region HHH_5 PF14520.6 EFO62244.1 - 0.00029 21.4 0.2 0.0011 19.5 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain 5_3_exonuc PF01367.20 EFO62244.1 - 0.0007 20.2 1.9 0.00084 19.9 0.0 2.1 3 1 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold XRN_N PF03159.18 EFO62244.1 - 0.0079 15.6 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus HSDR_N_2 PF13588.6 EFO62244.1 - 0.024 14.7 0.0 0.092 12.8 0.0 1.9 2 0 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) HHH PF00633.23 EFO62244.1 - 0.073 13.0 0.0 0.2 11.6 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif IPTL-CTERM PF18203.1 EFO62245.1 - 6.8 6.7 7.5 17 5.4 7.5 1.7 1 0 0 1 1 1 0 IPTL-CTERM motif RNA_pol_Rpc4 PF05132.14 EFO62246.1 - 3.8e-15 56.6 0.9 9.9e-15 55.3 0.1 2.0 2 1 0 2 2 2 1 RNA polymerase III RPC4 PRP4 PF08799.11 EFO62246.1 - 0.0021 17.5 0.0 0.0032 17.0 0.0 1.3 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like CAP59_mtransfer PF11735.8 EFO62247.1 - 0.16 11.6 2.9 5.5 6.6 0.2 2.4 2 0 0 2 2 2 0 Cryptococcal mannosyltransferase 1 POTRA_TamA_1 PF17243.2 EFO62247.1 - 0.44 10.7 3.2 0.53 10.4 0.2 2.6 2 0 0 2 2 2 0 POTRA domain TamA domain 1 Histone PF00125.24 EFO62248.1 - 5.1e-36 123.9 0.1 5.8e-36 123.8 0.1 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EFO62248.1 - 1.5e-05 25.0 0.0 2.6e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EFO62248.1 - 0.00089 19.5 0.1 0.0023 18.2 0.1 1.8 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PilO PF04350.13 EFO62248.1 - 0.029 14.5 0.0 0.032 14.4 0.0 1.1 1 0 0 1 1 1 0 Pilus assembly protein, PilO Bromo_TP PF07524.13 EFO62248.1 - 0.069 13.2 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 Bromodomain associated OST3_OST6 PF04756.13 EFO62250.1 - 6.2e-10 38.9 0.8 7.6e-10 38.6 0.8 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family AMP-binding PF00501.28 EFO62253.1 - 2.9e-79 266.6 0.0 5.8e-78 262.4 0.0 2.0 1 1 0 1 1 1 1 AMP-binding enzyme TIMELESS PF04821.14 EFO62254.1 - 0.095 12.0 0.1 0.15 11.3 0.1 1.2 1 0 0 1 1 1 0 Timeless protein TAF6_C PF07571.13 EFO62255.1 - 0.087 13.2 0.2 0.45 10.9 0.1 2.1 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain Ank_2 PF12796.7 EFO62257.1 - 5.3e-31 107.0 7.7 2.5e-09 37.6 1.2 4.5 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO62257.1 - 5.3e-22 75.5 8.4 0.0077 16.7 0.0 8.4 8 0 0 8 8 8 5 Ankyrin repeat Ank PF00023.30 EFO62257.1 - 9.2e-18 63.8 6.4 0.004 17.5 0.0 7.5 8 0 0 8 8 8 5 Ankyrin repeat Ank_5 PF13857.6 EFO62257.1 - 1.1e-17 63.8 10.4 0.00035 20.8 0.2 6.7 3 3 4 7 7 7 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62257.1 - 2.6e-14 53.4 8.5 0.013 16.1 0.1 5.5 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFO62258.1 - 2.4e-22 79.3 1.1 5.7e-12 46.1 0.1 3.9 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62258.1 - 9.3e-12 45.2 1.9 1e-05 26.0 0.0 5.5 5 1 1 6 6 6 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62258.1 - 1.3e-11 44.5 0.4 0.19 12.1 0.0 5.9 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62258.1 - 7.6e-09 35.1 1.7 0.082 13.5 0.0 6.9 7 0 0 7 7 6 1 Ankyrin repeat Ank PF00023.30 EFO62258.1 - 8.9e-08 32.2 0.3 0.0059 17.0 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat HMMR_N PF15905.5 EFO62258.1 - 0.022 14.2 27.8 0.31 10.5 7.0 3.4 3 0 0 3 3 3 0 Hyaluronan mediated motility receptor N-terminal DrrA_P4M PF14860.6 EFO62258.1 - 0.037 13.9 0.9 0.18 11.7 0.9 2.2 1 0 0 1 1 1 0 DrrA phosphatidylinositol 4-phosphate binding domain Spc42p PF11544.8 EFO62258.1 - 0.26 11.3 8.8 0.19 11.8 0.6 3.3 3 0 0 3 3 3 0 Spindle pole body component Spc42p DUF3461 PF11944.8 EFO62258.1 - 0.76 9.9 0.0 0.76 9.9 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3461) SlyX PF04102.12 EFO62258.1 - 1.7 9.3 21.3 0.22 12.2 3.1 5.2 3 2 1 4 4 4 0 SlyX TMF_DNA_bd PF12329.8 EFO62258.1 - 4.4 7.4 16.5 3.3 7.8 2.1 4.4 3 2 0 3 3 3 0 TATA element modulatory factor 1 DNA binding FliJ PF02050.16 EFO62258.1 - 6.4 7.0 16.7 2.4 8.4 5.0 3.6 3 0 0 3 3 3 0 Flagellar FliJ protein HPS3_N PF14761.6 EFO62260.1 - 0.14 11.6 0.0 2.3 7.7 0.0 2.3 2 0 0 2 2 2 0 Hermansky-Pudlak syndrome 3 Syja_N PF02383.18 EFO62261.1 - 4.4e-17 62.4 0.0 7.3e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain Elf1 PF05129.13 EFO62263.1 - 1.2e-10 41.3 3.7 1.7e-09 37.6 0.4 2.5 1 1 1 2 2 2 1 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.6 EFO62263.1 - 0.0015 18.4 1.4 0.14 12.1 0.5 2.5 2 0 0 2 2 2 2 zinc-ribbon domain DDE_Tnp_1_6 PF13751.6 EFO62263.1 - 0.019 15.2 1.1 0.019 15.2 1.1 1.8 2 0 0 2 2 2 0 Transposase DDE domain CpXC PF14353.6 EFO62263.1 - 0.024 14.7 1.3 2.2 8.4 0.0 2.7 2 1 1 3 3 3 0 CpXC protein Lar_restr_allev PF14354.6 EFO62263.1 - 0.21 12.0 3.8 0.84 10.1 0.1 2.6 2 1 0 2 2 2 0 Restriction alleviation protein Lar zf-DNL PF05180.12 EFO62263.1 - 0.33 10.9 2.7 0.33 10.9 0.4 2.1 2 0 0 2 2 2 0 DNL zinc finger Rad51 PF08423.11 EFO62265.1 - 1.4e-112 375.1 0.0 2.2e-112 374.5 0.0 1.3 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EFO62265.1 - 3.2e-12 46.5 0.1 5e-12 45.8 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 EFO62265.1 - 4.4e-07 29.5 0.5 1.9e-05 24.1 0.1 2.7 2 1 0 2 2 2 1 KaiC HHH_5 PF14520.6 EFO62265.1 - 7.3e-05 23.3 0.1 0.00078 20.0 0.6 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix domain DnaB_C PF03796.15 EFO62265.1 - 8.3e-05 22.0 0.1 0.029 13.7 0.0 2.5 3 0 0 3 3 3 2 DnaB-like helicase C terminal domain ATPase_2 PF01637.18 EFO62265.1 - 0.012 15.6 0.0 0.026 14.4 0.0 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EFO62265.1 - 0.015 15.5 0.0 0.028 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFO62265.1 - 0.021 14.5 0.0 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Elong_Iki1 PF10483.9 EFO62265.1 - 0.023 14.2 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 Elongator subunit Iki1 DUF4158 PF13700.6 EFO62265.1 - 0.056 13.3 0.1 0.13 12.1 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4158) Trm112p PF03966.16 EFO62266.1 - 1.6e-07 31.8 0.1 7.1e-07 29.7 0.1 1.8 1 1 0 1 1 1 1 Trm112p-like protein zinc_ribbon_4 PF13717.6 EFO62266.1 - 0.001 19.0 1.7 1.5 8.8 0.2 2.6 2 0 0 2 2 2 2 zinc-ribbon domain zf-RING_4 PF14570.6 EFO62266.1 - 0.027 14.3 1.2 5.3 6.9 0.1 3.1 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain zf-C2H2_4 PF13894.6 EFO62266.1 - 0.11 13.4 2.2 0.66 11.0 0.4 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger Prok-RING_1 PF14446.6 EFO62266.1 - 0.49 10.4 3.0 4.5 7.3 0.1 2.8 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Leu_zip PF15294.6 EFO62267.1 - 0.0055 16.3 2.1 0.0055 16.3 2.1 2.1 2 0 0 2 2 2 1 Leucine zipper MogR_DNAbind PF12181.8 EFO62267.1 - 0.029 14.3 0.2 0.058 13.3 0.2 1.5 1 0 0 1 1 1 0 DNA binding domain of the motility gene repressor (MogR) Fungal_TACC PF12709.7 EFO62267.1 - 0.035 14.5 1.5 0.035 14.5 1.5 1.9 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins bZIP_2 PF07716.15 EFO62267.1 - 0.076 13.1 0.9 0.076 13.1 0.9 3.1 5 0 0 5 5 5 0 Basic region leucine zipper DUF3153 PF11353.8 EFO62267.1 - 0.57 9.7 6.7 1 8.9 6.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3153) MCM3AP_GANP PF16769.5 EFO62267.1 - 0.66 8.2 13.2 0.38 8.9 11.3 1.3 1 1 0 1 1 1 0 MCM3AP domain of GANP DivIC PF04977.15 EFO62267.1 - 0.87 9.4 8.1 0.76 9.6 5.7 2.2 2 1 0 2 2 2 0 Septum formation initiator DUF5320 PF17253.2 EFO62267.1 - 1.1 10.3 2.6 2.3 9.3 1.1 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5320) M PF02370.16 EFO62267.1 - 5.6 7.9 10.2 1.8 9.4 0.1 3.8 2 1 1 3 3 3 0 M protein repeat Ank_2 PF12796.7 EFO62269.1 - 6.4e-15 55.5 2.1 1.8e-08 34.8 0.5 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62269.1 - 2.6e-06 27.9 0.2 0.27 11.9 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62269.1 - 5.5e-06 26.6 3.6 0.097 13.0 0.1 4.4 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62269.1 - 7.3e-06 26.0 2.7 1.4 9.7 0.0 4.9 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 EFO62269.1 - 1.8e-05 24.9 2.3 3.6 8.2 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeat MRVI1 PF05781.12 EFO62270.1 - 0.0097 14.6 1.8 0.012 14.4 1.8 1.1 1 0 0 1 1 1 1 MRVI1 protein Spectrin PF00435.21 EFO62270.1 - 0.037 14.5 4.1 0.078 13.5 3.9 1.7 1 1 0 1 1 1 0 Spectrin repeat Sec20 PF03908.13 EFO62270.1 - 0.088 12.7 2.2 0.21 11.5 2.2 1.6 1 0 0 1 1 1 0 Sec20 GAT PF03127.14 EFO62270.1 - 0.41 11.0 3.8 3.8 7.9 0.4 2.4 1 1 1 2 2 2 0 GAT domain ZapB PF06005.12 EFO62270.1 - 0.56 10.7 11.3 0.73 10.3 6.8 2.5 1 1 1 2 2 2 0 Cell division protein ZapB V-SNARE_C PF12352.8 EFO62271.1 - 0.00075 19.7 0.2 0.0026 18.0 0.2 1.9 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus SPICE PF15678.5 EFO62271.1 - 0.021 14.2 0.4 0.026 13.9 0.4 1.1 1 0 0 1 1 1 0 Centriole duplication and mitotic chromosome congression Amidohydro_1 PF01979.20 EFO62271.1 - 0.069 12.5 0.1 0.079 12.3 0.1 1.2 1 0 0 1 1 1 0 Amidohydrolase family FUSC PF04632.12 EFO62271.1 - 0.073 11.6 2.3 0.095 11.2 2.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family PA28_beta PF02252.18 EFO62272.1 - 0.00072 19.2 0.5 0.0015 18.2 0.5 1.6 1 1 0 1 1 1 1 Proteasome activator pa28 beta subunit DUF489 PF04356.12 EFO62272.1 - 0.013 15.5 0.4 3.7 7.5 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF489) ADSL_C PF10397.9 EFO62272.1 - 0.13 12.8 1.4 13 6.4 0.0 2.7 1 1 1 2 2 2 0 Adenylosuccinate lyase C-terminus MutS_V PF00488.21 EFO62273.1 - 3.8e-39 134.7 0.0 6.8e-39 133.8 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 EFO62273.1 - 9.9e-21 74.1 0.0 3.7e-20 72.3 0.0 2.0 2 0 0 2 2 2 1 MutS domain I MutS_III PF05192.18 EFO62273.1 - 4e-14 53.3 2.7 2.8e-13 50.5 2.7 2.3 1 1 0 1 1 1 1 MutS domain III SLED PF12140.8 EFO62273.1 - 0.083 13.4 0.3 0.26 11.8 0.3 1.9 1 0 0 1 1 1 0 SLED domain AAA_22 PF13401.6 EFO62273.1 - 0.12 12.6 0.2 0.74 10.1 0.2 2.3 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFO62273.1 - 0.15 12.1 0.0 0.9 9.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain Tfb4 PF03850.14 EFO62274.1 - 1.4e-09 37.9 12.9 3.2e-09 36.7 12.8 1.6 1 1 0 1 1 1 1 Transcription factor Tfb4 DUF5612 PF18462.1 EFO62274.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5612) Mob1_phocein PF03637.17 EFO62275.1 - 3e-31 108.7 1.6 5.7e-31 107.8 1.6 1.4 1 1 0 1 1 1 1 Mob1/phocein family Maf1 PF09174.10 EFO62276.1 - 4e-22 79.2 0.1 5.6e-22 78.7 0.1 1.2 1 0 0 1 1 1 1 Maf1 regulator AvrL567-A PF11529.8 EFO62276.1 - 0.11 12.7 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Melampsora lini avirulence protein AvrL567-A VSP PF03302.13 EFO62277.1 - 4e-24 85.2 48.6 2.3e-19 69.5 9.5 3.0 1 1 2 3 3 3 3 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO62277.1 - 0.00018 21.6 20.3 0.0011 19.1 2.1 3.2 1 1 2 3 3 3 3 Furin-like repeat, cysteine-rich Ank_2 PF12796.7 EFO62278.1 - 6e-14 52.4 1.6 2.3e-08 34.5 0.3 3.1 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62278.1 - 2.2e-09 37.4 0.1 0.00022 21.4 0.1 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62278.1 - 1.8e-05 24.8 2.1 0.57 10.9 0.1 4.7 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 EFO62278.1 - 4.1e-05 24.0 0.3 0.00032 21.2 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EFO62278.1 - 0.042 14.3 1.2 20 5.9 0.0 3.7 3 0 0 3 3 3 0 Ankyrin repeat CALCOCO1 PF07888.11 EFO62278.1 - 0.27 10.0 12.0 0.48 9.2 12.0 1.3 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF641 PF04859.12 EFO62278.1 - 0.43 10.9 13.8 0.16 12.3 1.4 3.5 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) SlyX PF04102.12 EFO62278.1 - 0.78 10.4 14.4 5.7 7.6 0.4 4.1 4 0 0 4 4 4 0 SlyX DUF724 PF05266.14 EFO62278.1 - 2.2 8.1 9.7 0.85 9.4 3.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Fib_alpha PF08702.10 EFO62278.1 - 4.9 7.3 7.0 3.8 7.7 1.8 2.9 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Cep57_MT_bd PF06657.13 EFO62278.1 - 6.3 7.3 9.6 9.6 6.7 0.1 3.8 4 0 0 4 4 4 0 Centrosome microtubule-binding domain of Cep57 CortBP2 PF09727.9 EFO62278.1 - 7.2 6.5 17.9 2.9 7.8 2.2 2.6 2 1 1 3 3 3 0 Cortactin-binding protein-2 PKcGMP_CC PF16808.5 EFO62278.1 - 8.6 6.3 10.7 0.25 11.2 1.5 2.9 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase HR1 PF02185.16 EFO62278.1 - 9.4 6.4 9.7 4.2 7.6 0.0 3.2 4 0 0 4 4 4 0 Hr1 repeat Metallophos PF00149.28 EFO62279.1 - 9e-11 42.7 0.0 1.3e-10 42.2 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase tRNA-synt_1 PF00133.22 EFO62280.1 - 2.6e-169 564.3 0.0 7.9e-103 344.8 0.0 3.0 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EFO62280.1 - 5.8e-47 159.5 0.0 1.3e-46 158.3 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EFO62280.1 - 1.9e-10 40.1 0.4 9e-05 21.4 0.0 4.1 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EFO62280.1 - 3e-08 33.4 0.0 2.1e-06 27.4 0.0 2.4 1 1 1 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EFO62280.1 - 0.015 14.6 0.0 5.5 6.2 0.0 2.9 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain DUF4349 PF14257.6 EFO62280.1 - 0.088 12.2 0.2 0.17 11.3 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) MmlI PF09448.10 EFO62280.1 - 0.098 13.1 0.1 2.3 8.7 0.0 2.5 2 0 0 2 2 2 0 Methylmuconolactone methyl-isomerase tRNA-synt_1d PF00750.19 EFO62280.1 - 0.14 11.0 0.0 0.28 10.1 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (R) MRP-S35 PF10246.9 EFO62280.1 - 0.15 12.1 0.2 0.5 10.3 0.0 1.9 2 0 0 2 2 2 0 Mitochondrial ribosomal protein MRP-S35 Val_tRNA-synt_C PF10458.9 EFO62280.1 - 0.16 12.3 1.2 0.4 11.0 1.2 1.7 1 0 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm PRKG1_interact PF15898.5 EFO62280.1 - 0.32 11.9 3.1 0.95 10.4 3.1 1.7 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain ABC_tran_CTD PF16326.5 EFO62281.1 - 0.0012 19.0 0.9 0.071 13.4 0.9 2.7 1 1 1 2 2 2 2 ABC transporter C-terminal domain FliJ PF02050.16 EFO62281.1 - 0.075 13.3 1.4 0.24 11.6 1.4 1.9 1 0 0 1 1 1 0 Flagellar FliJ protein VSP PF03302.13 EFO62282.1 - 4e-12 45.7 169.2 1.3e-05 24.2 31.2 5.5 1 1 4 5 5 5 4 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO62282.1 - 0.012 15.8 14.9 0.012 15.8 14.9 8.6 2 2 5 8 8 8 0 Furin-like repeat, cysteine-rich SKG6 PF08693.10 EFO62282.1 - 0.028 13.8 4.9 0.053 12.9 4.9 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain MLANA PF14991.6 EFO62282.1 - 0.036 14.3 0.0 0.087 13.1 0.0 1.6 1 0 0 1 1 1 0 Protein melan-A RIFIN PF02009.16 EFO62282.1 - 2.8 7.7 9.2 0.077 12.9 0.4 2.2 2 0 0 2 2 2 0 Rifin UDG PF03167.19 EFO62284.1 - 0.00089 19.3 0.0 0.0052 16.8 0.0 2.0 1 1 0 1 1 1 1 Uracil DNA glycosylase superfamily Cyclin PF08613.11 EFO62285.1 - 0.02 15.2 0.4 0.04 14.3 0.4 1.4 1 1 0 1 1 1 0 Cyclin Aa_trans PF01490.18 EFO62286.1 - 4.2e-34 118.0 37.5 9.4e-19 67.4 11.5 2.2 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein ATG27 PF09451.10 EFO62286.1 - 0.41 10.5 4.6 2.8 7.7 0.1 2.5 2 0 0 2 2 2 0 Autophagy-related protein 27 IBV_3C PF03620.13 EFO62286.1 - 1.8 9.1 7.8 0.34 11.4 2.2 2.7 2 0 0 2 2 2 0 IBV 3C protein Methyltr_RsmB-F PF01189.17 EFO62287.1 - 4.5e-59 199.5 0.0 6.3e-59 199.0 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EFO62287.1 - 7.8e-11 42.3 0.0 1.7e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Met_10 PF02475.16 EFO62287.1 - 0.0065 16.2 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein DUF2431 PF10354.9 EFO62287.1 - 0.013 15.8 0.0 0.023 14.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) FtsJ PF01728.19 EFO62287.1 - 0.056 13.5 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 EFO62287.1 - 0.11 11.9 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Baculo_PEP_C PF04513.12 EFO62289.1 - 0.00043 20.3 5.0 0.0053 16.8 0.2 2.4 1 1 1 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4795 PF16043.5 EFO62289.1 - 0.0071 16.0 1.5 0.028 14.0 1.5 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4795) IFT57 PF10498.9 EFO62289.1 - 0.026 13.5 2.8 0.03 13.3 1.9 1.4 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 YojJ PF10372.9 EFO62289.1 - 0.026 14.6 4.1 3.4 7.8 0.6 3.0 1 1 2 3 3 3 0 Bacterial membrane-spanning protein N-terminus LXG PF04740.12 EFO62289.1 - 0.034 13.9 5.2 0.22 11.2 0.7 2.4 1 1 1 2 2 2 0 LXG domain of WXG superfamily Prefoldin_2 PF01920.20 EFO62289.1 - 0.044 13.7 1.1 4.9 7.2 0.1 2.5 2 1 0 2 2 2 0 Prefoldin subunit Laminin_II PF06009.12 EFO62289.1 - 0.05 13.6 1.5 0.29 11.2 0.0 2.4 1 1 2 3 3 3 0 Laminin Domain II Apolipoprotein PF01442.18 EFO62289.1 - 0.076 12.9 3.7 0.92 9.4 3.3 2.2 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain Focal_AT PF03623.13 EFO62289.1 - 0.11 12.5 0.6 0.49 10.4 0.1 1.9 1 1 1 2 2 2 0 Focal adhesion targeting region HrpB7 PF09486.10 EFO62289.1 - 0.15 12.5 1.5 0.41 11.0 0.7 2.1 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) ImpA_N PF06812.12 EFO62289.1 - 0.15 12.1 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 ImpA, N-terminal, type VI secretion system DASH_Duo1 PF08651.10 EFO62289.1 - 0.19 11.5 3.6 0.51 10.1 0.1 2.6 3 0 0 3 3 3 0 DASH complex subunit Duo1 DUF16 PF01519.16 EFO62289.1 - 0.22 12.1 3.0 0.37 11.3 0.9 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 WXG100 PF06013.12 EFO62289.1 - 0.24 11.6 3.2 1.6 9.0 0.1 3.1 3 0 0 3 3 3 0 Proteins of 100 residues with WXG DUF1664 PF07889.12 EFO62289.1 - 0.28 11.2 4.5 0.33 11.0 1.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FliJ PF02050.16 EFO62289.1 - 9.6 6.5 7.8 1.5 9.0 0.7 2.5 3 0 0 3 3 3 0 Flagellar FliJ protein Yip1 PF04893.17 EFO62290.1 - 7.8e-11 42.0 20.3 1.2e-10 41.4 20.3 1.3 1 0 0 1 1 1 1 Yip1 domain HDV_ag PF01517.18 EFO62291.1 - 0.14 11.9 0.4 0.41 10.4 0.0 2.0 2 0 0 2 2 2 0 Hepatitis delta virus delta antigen PRKG1_interact PF15898.5 EFO62291.1 - 1.5 9.8 10.3 0.059 14.3 1.7 2.8 3 0 0 3 3 3 0 cGMP-dependent protein kinase interacting domain DUF842 PF05811.13 EFO62294.1 - 0.014 15.1 0.1 0.97 9.1 0.0 2.3 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) Carn_acyltransf PF00755.20 EFO62294.1 - 0.08 11.6 0.1 0.1 11.2 0.1 1.2 1 0 0 1 1 1 0 Choline/Carnitine o-acyltransferase VSP PF03302.13 EFO62295.1 - 5.9e-150 499.5 178.9 1.3e-136 455.6 99.2 4.0 1 1 3 4 4 4 3 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO62295.1 - 0.042 14.0 0.1 0.12 12.5 0.1 1.7 1 0 0 1 1 1 0 Podoplanin SKG6 PF08693.10 EFO62295.1 - 0.11 11.9 5.0 0.22 11.0 5.0 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Atg14 PF10186.9 EFO62296.1 - 2e-05 23.9 4.2 2e-05 23.9 4.2 2.8 1 1 2 3 3 3 2 Vacuolar sorting 38 and autophagy-related subunit 14 Fez1 PF06818.15 EFO62296.1 - 0.0015 19.0 22.4 0.14 12.6 12.8 3.6 1 1 2 3 3 3 3 Fez1 HeH PF12949.7 EFO62296.1 - 0.03 14.0 0.2 0.33 10.7 0.1 2.6 2 0 0 2 2 2 0 HeH/LEM domain DUF4279 PF14106.6 EFO62296.1 - 0.039 14.1 2.8 0.43 10.8 0.2 2.8 2 2 0 2 2 2 0 Domain of unknown function (DUF4279) HMMR_N PF15905.5 EFO62296.1 - 0.088 12.3 30.4 0.44 10.0 14.8 2.8 2 2 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF1192 PF06698.11 EFO62296.1 - 0.11 12.6 18.1 2.5 8.2 0.1 4.9 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) XPC-binding PF09280.11 EFO62296.1 - 0.28 10.9 4.5 0.27 11.0 2.5 2.0 2 0 0 2 2 2 0 XPC-binding domain Lebercilin PF15619.6 EFO62296.1 - 0.33 10.6 33.7 0.51 10.0 9.2 3.8 1 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease FAM76 PF16046.5 EFO62296.1 - 0.51 9.6 22.6 0.33 10.3 5.2 3.6 1 1 3 4 4 4 0 FAM76 protein Cnn_1N PF07989.11 EFO62296.1 - 0.92 9.7 27.2 0.2 11.9 0.5 5.6 3 1 3 6 6 6 0 Centrosomin N-terminal motif 1 DUF641 PF04859.12 EFO62296.1 - 1.1 9.6 24.0 5.6 7.3 0.7 5.0 2 1 2 5 5 5 0 Plant protein of unknown function (DUF641) PHM7_cyt PF14703.6 EFO62296.1 - 2 8.6 9.1 3.8 7.7 0.4 3.3 1 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter DUF1664 PF07889.12 EFO62296.1 - 2.7 8.0 18.0 0.28 11.2 0.7 4.1 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) SlyX PF04102.12 EFO62296.1 - 3 8.5 26.0 5.4 7.7 3.7 5.4 5 1 0 5 5 5 0 SlyX DUF5082 PF16888.5 EFO62296.1 - 3.3 8.0 25.3 52 4.1 14.2 3.8 2 2 0 2 2 2 0 Domain of unknown function (DUF5082) BST2 PF16716.5 EFO62296.1 - 5.1 7.8 24.3 1.2 9.8 3.2 4.8 2 2 3 5 5 5 0 Bone marrow stromal antigen 2 HrpB7 PF09486.10 EFO62296.1 - 7 7.0 19.3 3.5 8.0 0.1 4.2 3 1 0 4 4 4 0 Bacterial type III secretion protein (HrpB7) BLOC1_2 PF10046.9 EFO62298.1 - 0.00034 20.9 4.1 0.0065 16.8 0.5 3.2 2 1 2 4 4 4 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_PEP_C PF04513.12 EFO62298.1 - 0.0006 19.9 6.0 0.093 12.8 0.4 3.1 2 2 0 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF16 PF01519.16 EFO62298.1 - 0.02 15.4 8.6 9.8 6.7 7.6 3.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 FAM184 PF15665.5 EFO62298.1 - 0.034 13.9 3.4 1.6 8.4 0.4 2.3 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B DUF1664 PF07889.12 EFO62298.1 - 0.067 13.2 7.2 0.091 12.8 0.8 3.1 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) Synaptobrevin PF00957.21 EFO62298.1 - 0.1 12.4 1.2 0.2 11.5 0.3 2.0 2 0 0 2 2 2 0 Synaptobrevin TACC_C PF05010.14 EFO62298.1 - 0.11 12.3 5.2 0.6 9.9 3.4 2.5 1 1 2 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DASH_Dam1 PF08653.10 EFO62298.1 - 0.11 12.3 2.3 17 5.3 0.0 4.0 3 1 1 4 4 4 0 DASH complex subunit Dam1 DUF4446 PF14584.6 EFO62298.1 - 0.19 11.7 3.9 0.86 9.6 0.2 2.6 1 1 3 4 4 4 0 Protein of unknown function (DUF4446) FlaC_arch PF05377.11 EFO62298.1 - 0.21 12.0 4.0 9 6.8 0.0 3.6 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Exonuc_VII_L PF02601.15 EFO62298.1 - 0.23 11.0 6.2 0.64 9.5 6.1 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit Cep57_MT_bd PF06657.13 EFO62298.1 - 0.25 11.8 0.3 0.25 11.8 0.3 3.3 3 1 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 ABC_tran_CTD PF16326.5 EFO62298.1 - 0.31 11.3 10.3 0.65 10.3 1.0 3.6 2 2 0 3 3 3 0 ABC transporter C-terminal domain Fez1 PF06818.15 EFO62298.1 - 0.33 11.4 6.2 0.42 11.0 4.9 1.8 1 1 0 1 1 1 0 Fez1 Trimer_CC PF08954.11 EFO62298.1 - 0.34 10.5 0.1 0.34 10.5 0.1 2.9 4 0 0 4 4 3 0 Trimerisation motif UPF0449 PF15136.6 EFO62298.1 - 0.41 11.1 4.4 3.1 8.3 0.1 2.9 2 1 0 2 2 2 0 Uncharacterised protein family UPF0449 Tropomyosin PF00261.20 EFO62298.1 - 0.61 9.4 10.2 1.6 8.0 5.0 2.5 1 1 1 2 2 2 0 Tropomyosin Fib_alpha PF08702.10 EFO62298.1 - 0.81 9.9 8.2 30 4.8 4.7 3.1 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Prefoldin PF02996.17 EFO62298.1 - 1.4 8.9 6.9 1.8 8.5 0.2 3.4 2 2 0 2 2 2 0 Prefoldin subunit Fzo_mitofusin PF04799.13 EFO62298.1 - 1.6 8.2 6.0 2.7 7.5 0.2 3.0 2 1 1 3 3 3 0 fzo-like conserved region XhlA PF10779.9 EFO62298.1 - 2 8.7 10.7 2.2 8.5 0.1 4.1 3 1 0 3 3 3 0 Haemolysin XhlA DUF4164 PF13747.6 EFO62298.1 - 3 8.2 9.0 0.75 10.1 0.2 3.6 2 2 1 3 3 3 0 Domain of unknown function (DUF4164) Prefoldin_2 PF01920.20 EFO62298.1 - 3.8 7.5 9.2 4.8 7.2 0.2 3.8 2 2 0 2 2 2 0 Prefoldin subunit CLZ PF16526.5 EFO62298.1 - 5.1 7.5 11.0 1.3 9.5 0.6 4.1 3 2 2 5 5 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels SlyX PF04102.12 EFO62298.1 - 5.2 7.8 7.9 6 7.6 0.9 3.6 3 1 0 3 3 3 0 SlyX DUF4094 PF13334.6 EFO62298.1 - 5.6 7.4 7.0 8.2 6.9 0.3 3.1 2 2 0 2 2 2 0 Domain of unknown function (DUF4094) Pkinase PF00069.25 EFO62299.1 - 1.8e-07 30.8 0.0 5e-07 29.3 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62299.1 - 0.00029 20.2 0.0 0.00058 19.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase FAM76 PF16046.5 EFO62299.1 - 0.0079 15.6 7.5 0.0079 15.6 7.5 2.0 1 1 1 2 2 2 1 FAM76 protein PKcGMP_CC PF16808.5 EFO62299.1 - 0.009 15.9 0.8 0.03 14.2 0.8 1.9 1 0 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Malate_synthase PF01274.22 EFO62299.1 - 0.085 11.1 0.2 0.13 10.5 0.2 1.2 1 0 0 1 1 1 0 Malate synthase KELK PF15796.5 EFO62299.1 - 0.14 12.7 3.7 4.3 7.9 0.4 2.6 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Fib_alpha PF08702.10 EFO62299.1 - 0.73 10.0 4.0 2.3 8.4 0.1 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF641 PF04859.12 EFO62299.1 - 1.2 9.5 5.9 6 7.2 0.5 2.5 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) SlyX PF04102.12 EFO62299.1 - 1.8 9.3 5.0 5.2 7.8 0.4 2.4 2 0 0 2 2 2 0 SlyX DUF4407 PF14362.6 EFO62299.1 - 3.2 7.0 6.3 5.8 6.2 6.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GAS PF13851.6 EFO62299.1 - 3.3 7.0 9.2 1.1 8.6 2.9 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 EFO62299.1 - 5.7 7.3 10.5 6.4 7.2 1.0 2.2 1 1 0 2 2 2 0 Fez1 Ank_2 PF12796.7 EFO62300.1 - 1.4e-25 89.7 4.6 1.1e-07 32.4 0.3 4.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EFO62300.1 - 1.5e-13 50.5 2.7 0.0016 18.8 0.0 6.3 6 0 0 6 6 6 3 Ankyrin repeat Ank_3 PF13606.6 EFO62300.1 - 2.9e-12 45.6 0.5 0.15 12.7 0.0 5.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EFO62300.1 - 7.3e-12 45.3 7.5 0.0036 17.6 0.1 5.4 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62300.1 - 2.2e-07 31.3 1.5 0.25 12.0 0.0 4.6 3 1 0 4 4 4 2 Ankyrin repeats (many copies) 3HCDH_RFF PF18321.1 EFO62300.1 - 1.2 9.6 5.9 89 3.6 0.0 4.1 3 1 0 3 3 3 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain Raptor_N PF14538.6 EFO62301.1 - 8.3e-12 45.3 0.0 3.9e-11 43.1 0.0 2.3 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain Cucumo_coat PF00760.18 EFO62301.1 - 0.03 14.0 0.0 0.1 12.3 0.0 1.9 1 0 0 1 1 1 0 Cucumovirus coat protein DUF1548 PF07579.11 EFO62302.1 - 0.075 13.4 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1548) Ank_2 PF12796.7 EFO62303.1 - 1.6e-34 118.3 8.3 1.7e-10 41.4 0.0 5.7 3 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62303.1 - 1.8e-17 63.5 3.3 1.5e-05 25.5 0.0 6.3 5 1 1 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62303.1 - 5e-14 52.2 6.9 0.016 15.5 0.0 6.7 4 3 3 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62303.1 - 1.5e-11 43.5 8.8 0.14 12.8 0.0 7.5 8 0 0 8 8 8 4 Ankyrin repeat Ank PF00023.30 EFO62303.1 - 1.4e-10 41.1 3.9 0.05 14.1 0.0 6.8 6 0 0 6 6 6 4 Ankyrin repeat Spc42p PF11544.8 EFO62303.1 - 0.24 11.4 18.9 0.86 9.6 0.0 7.4 7 0 0 7 7 7 0 Spindle pole body component Spc42p HALZ PF02183.18 EFO62303.1 - 3.2 8.0 32.7 1.9 8.8 0.2 7.3 6 0 0 6 6 6 0 Homeobox associated leucine zipper Ank_2 PF12796.7 EFO62304.1 - 1.1e-13 51.6 0.3 1.3e-10 41.7 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62304.1 - 4.9e-08 33.3 0.1 0.026 15.1 0.0 4.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62304.1 - 0.00018 21.7 0.8 0.012 15.9 0.0 3.2 1 1 3 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO62304.1 - 0.00096 19.5 0.1 3.4 8.3 0.1 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EFO62304.1 - 0.0025 18.1 0.1 8.9 7.3 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat GCP_C_terminal PF04130.13 EFO62304.1 - 0.028 13.9 0.5 0.073 12.5 0.5 1.7 1 0 0 1 1 1 0 Gamma tubulin complex component C-terminal DEAD PF00270.29 EFO62305.1 - 1e-29 103.6 0.0 1.7e-29 102.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO62305.1 - 3e-24 85.5 0.0 3.7e-23 82.0 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFO62305.1 - 0.0031 17.5 0.0 0.0055 16.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Methyltransf_11 PF08241.12 EFO62307.1 - 2e-15 57.2 0.0 3.5e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFO62307.1 - 3.1e-12 47.0 0.0 6.4e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFO62307.1 - 8.7e-10 38.6 0.0 1.2e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFO62307.1 - 1.7e-08 35.1 0.0 3.2e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFO62307.1 - 9.4e-08 32.1 0.0 1.3e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFO62307.1 - 0.0018 17.6 0.0 0.0025 17.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EFO62307.1 - 0.039 13.3 0.0 0.068 12.5 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 EFO62307.1 - 0.063 13.1 0.1 0.2 11.5 0.1 1.8 1 1 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_9 PF08003.11 EFO62307.1 - 0.074 12.0 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) TehB PF03848.14 EFO62307.1 - 0.12 11.7 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB N2227 PF07942.12 EFO62308.1 - 0.18 11.0 0.0 0.32 10.1 0.0 1.3 1 0 0 1 1 1 0 N2227-like protein Ank_2 PF12796.7 EFO62309.1 - 2.1e-21 76.3 0.8 3.4e-10 40.4 0.1 2.8 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFO62309.1 - 2e-14 53.3 0.4 0.00063 20.1 0.0 5.0 5 1 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EFO62309.1 - 1.4e-12 47.6 1.9 0.00021 21.5 0.1 4.3 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62309.1 - 2.8e-12 45.6 0.4 0.0063 16.9 0.0 4.9 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EFO62309.1 - 3.5e-08 33.8 0.6 4.4e-05 23.9 0.1 3.2 1 1 3 4 4 4 3 Ankyrin repeats (many copies) CLCA PF08434.11 EFO62309.1 - 0.062 12.6 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Calcium-activated chloride channel N terminal Shugoshin_N PF07558.11 EFO62309.1 - 0.16 11.8 8.4 0.17 11.8 3.0 2.8 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Peptidase_M24 PF00557.24 EFO62312.1 - 9.6e-38 130.0 0.0 1.6e-37 129.2 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 DUF410 PF04190.13 EFO62313.1 - 0.071 12.9 0.1 1.1 9.0 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF410) S-AdoMet_synt_C PF02773.16 EFO62315.1 - 4.5e-53 179.0 0.0 9.1e-53 178.0 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_N PF00438.20 EFO62315.1 - 7.4e-39 132.4 1.0 2.5e-38 130.7 0.9 1.9 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_M PF02772.16 EFO62315.1 - 7.3e-31 106.9 0.0 6e-30 104.0 0.0 2.4 3 0 0 3 3 3 1 S-adenosylmethionine synthetase, central domain AdoMet_Synthase PF01941.19 EFO62315.1 - 0.13 11.0 1.2 0.51 9.1 0.1 2.2 2 1 1 3 3 3 0 S-adenosylmethionine synthetase (AdoMet synthetase) DUF1284 PF06935.11 EFO62315.1 - 0.14 12.6 1.1 0.58 10.6 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1284) Ribosomal_L28e PF01778.17 EFO62317.1 - 7.6e-29 100.8 2.1 9.4e-29 100.5 0.1 2.0 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 EFO62317.1 - 1.7e-18 67.1 12.2 1.7e-18 67.1 12.2 1.7 2 0 0 2 2 2 1 Mak16 protein C-terminal region DUF1729 PF08354.10 EFO62317.1 - 0.032 13.1 0.7 0.046 12.6 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1729) Pkinase PF00069.25 EFO62319.1 - 2.3e-42 145.2 0.0 3.4e-42 144.6 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62319.1 - 2e-14 53.5 0.0 3.1e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO62320.1 - 6.8e-81 266.9 0.1 3e-15 56.6 0.1 5.2 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62320.1 - 6.3e-38 128.7 2.5 1.6e-08 34.9 0.2 6.9 5 1 2 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO62320.1 - 2e-33 113.3 2.2 8.3e-05 22.9 0.0 8.6 7 2 2 9 9 9 6 Ankyrin repeat Ank_3 PF13606.6 EFO62320.1 - 6.4e-30 99.9 0.6 0.0018 18.6 0.0 9.5 9 0 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 EFO62320.1 - 1.3e-29 101.9 10.6 1.4e-05 25.2 0.0 7.9 1 1 7 8 8 8 6 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO62320.1 - 5.3e-17 62.0 0.0 1.6e-16 60.5 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62320.1 - 8.9e-12 44.8 0.0 1.5e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase T3SSipB PF16535.5 EFO62320.1 - 1.2 9.6 4.9 2 8.9 4.9 1.3 1 0 0 1 1 1 0 Type III cell invasion protein SipB DUF2894 PF11445.8 EFO62320.1 - 1.9 8.9 5.4 3.3 8.2 5.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) SLIDE PF09111.10 EFO62322.1 - 0.082 12.9 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 SLIDE Skp1 PF01466.19 EFO62323.1 - 7.2e-06 26.0 0.0 1.2e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain DUF1380 PF07128.12 EFO62323.1 - 0.073 13.3 0.0 1.3 9.3 0.1 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF1380) AAA_16 PF13191.6 EFO62324.1 - 7.4e-06 26.5 0.5 0.00013 22.4 0.5 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFO62324.1 - 0.0042 17.4 0.0 0.0098 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain Ribosomal_L7Ae PF01248.26 EFO62325.1 - 2.3e-18 65.7 0.0 2.8e-18 65.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family THOC2_N PF16134.5 EFO62326.1 - 0.054 12.1 0.0 0.087 11.4 0.0 1.2 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus HEAT_2 PF13646.6 EFO62326.1 - 0.068 13.6 0.0 0.24 11.8 0.0 2.0 1 0 0 1 1 1 0 HEAT repeats TMEM18 PF14770.6 EFO62327.1 - 2.2e-10 40.6 4.5 3.2e-10 40.0 4.5 1.2 1 0 0 1 1 1 1 Transmembrane protein 18 MMU163 PF17119.5 EFO62327.1 - 0.057 12.6 0.0 0.078 12.1 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis DUF4834 PF16118.5 EFO62327.1 - 0.22 12.5 0.0 0.22 12.5 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) IMS PF00817.20 EFO62328.1 - 4.5e-26 91.7 0.0 8.6e-26 90.7 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family BRCT_2 PF16589.5 EFO62328.1 - 2.8e-08 34.1 0.0 1.5e-07 31.7 0.0 2.2 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFO62328.1 - 3e-08 33.9 0.0 1.1e-07 32.1 0.0 2.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF1805 PF08827.11 EFO62328.1 - 0.00012 22.3 0.1 0.00069 19.9 0.0 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF1805) PTCB-BRCT PF12738.7 EFO62328.1 - 0.0015 18.5 0.0 0.0031 17.4 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain LIG3_BRCT PF16759.5 EFO62328.1 - 0.004 17.4 0.1 0.012 15.9 0.1 1.8 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain Toxin_YhaV PF11663.8 EFO62328.1 - 0.019 15.0 0.7 0.038 14.0 0.7 1.4 1 0 0 1 1 1 0 Toxin with endonuclease activity, of toxin-antitoxin system IMS_HHH PF11798.8 EFO62328.1 - 0.063 13.6 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 IMS family HHH motif DctP PF03480.13 EFO62329.1 - 0.067 12.5 2.6 3.7 6.8 0.1 2.4 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein, family 7 U1snRNP70_N PF12220.8 EFO62329.1 - 1 10.0 7.1 0.87 10.3 2.3 3.2 2 1 1 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal HALZ PF02183.18 EFO62329.1 - 5.5 7.3 22.4 0.042 14.1 2.2 5.0 5 0 0 5 5 5 0 Homeobox associated leucine zipper Ank_2 PF12796.7 EFO62330.1 - 2.3e-18 66.6 0.1 1.4e-07 32.0 0.0 3.1 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFO62330.1 - 6e-10 39.1 1.4 0.19 12.2 0.0 5.8 6 0 0 6 6 6 3 Ankyrin repeat Ank_3 PF13606.6 EFO62330.1 - 7.4e-09 35.1 0.7 0.074 13.6 0.1 5.5 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 EFO62330.1 - 3.3e-07 30.5 3.6 0.0057 16.9 0.3 4.8 2 2 2 5 5 5 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62330.1 - 5e-07 30.2 0.7 0.032 14.8 0.0 3.9 2 2 1 3 3 3 3 Ankyrin repeats (many copies) DUF2746 PF10874.8 EFO62330.1 - 2.1 8.8 8.0 58 4.2 0.8 4.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2746) VSP PF03302.13 EFO62333.1 - 1.3e-172 574.2 618.7 7e-17 61.4 46.3 23.4 1 1 18 20 20 20 19 Giardia variant-specific surface protein Ank_2 PF12796.7 EFO62334.1 - 1.4e-23 83.3 7.1 1.3e-10 41.7 0.2 3.2 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO62334.1 - 1.1e-12 46.9 1.1 0.0021 18.4 0.0 4.9 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EFO62334.1 - 3.4e-12 46.3 3.9 6.3e-06 26.4 0.2 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO62334.1 - 2.2e-11 43.6 2.1 0.0003 21.1 0.0 4.6 3 1 1 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EFO62334.1 - 4.4e-11 43.1 1.8 0.0088 16.6 0.0 4.2 4 0 0 4 4 3 3 Ankyrin repeats (many copies) CCDC92 PF14916.6 EFO62334.1 - 0.024 14.4 1.2 10 6.0 0.2 3.4 2 0 0 2 2 2 0 Coiled-coil domain of unknown function AvrM_N PF18247.1 EFO62334.1 - 0.058 13.3 0.2 0.23 11.4 0.2 2.0 1 0 0 1 1 1 0 Flax-rust effector AvrM N-terminal domain S6PP_C PF08472.10 EFO62334.1 - 0.11 12.4 0.0 3.3 7.6 0.0 2.7 2 0 0 2 2 2 0 Sucrose-6-phosphate phosphohydrolase C-terminal Ribosomal_L36e PF01158.18 EFO62334.1 - 0.78 10.0 7.6 0.15 12.3 0.5 3.2 3 0 0 3 3 3 0 Ribosomal protein L36e Tup_N PF08581.10 EFO62334.1 - 0.96 9.8 17.5 3.5 8.0 0.7 5.1 4 2 1 5 5 5 0 Tup N-terminal PKcGMP_CC PF16808.5 EFO62334.1 - 1 9.3 19.0 1.1 9.2 0.9 5.2 5 0 0 5 5 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase FixO PF02433.15 EFO62334.1 - 1.1 8.6 4.0 0.71 9.3 0.1 2.6 2 1 1 3 3 3 0 Cytochrome C oxidase, mono-heme subunit/FixO VGPC1_C PF16799.5 EFO62334.1 - 2.3 8.2 8.5 11 6.1 0.4 3.2 3 0 0 3 3 3 0 C-terminal membrane-localisation domain of ion-channel, VCN1 DivIC PF04977.15 EFO62334.1 - 2.6 7.9 34.1 0.24 11.2 0.6 7.5 5 2 0 7 7 7 0 Septum formation initiator TMF_DNA_bd PF12329.8 EFO62334.1 - 2.6 8.1 37.7 0.3 11.1 1.6 6.2 6 2 1 7 7 7 0 TATA element modulatory factor 1 DNA binding FlaC_arch PF05377.11 EFO62334.1 - 5.7 7.4 11.3 8 6.9 0.2 4.5 5 0 0 5 5 4 0 Flagella accessory protein C (FlaC) Ank_2 PF12796.7 EFO62335.1 - 9.4e-36 122.3 11.9 6.8e-12 45.8 0.5 5.7 2 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62335.1 - 5.7e-22 77.5 8.1 0.00066 19.9 0.1 7.7 5 3 2 7 7 7 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62335.1 - 7e-19 67.9 4.7 0.011 16.3 0.7 6.5 4 1 2 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62335.1 - 4.2e-17 60.5 7.8 0.2 12.3 0.0 8.6 8 0 0 8 8 8 5 Ankyrin repeat Ank PF00023.30 EFO62335.1 - 1.1e-16 60.4 11.4 0.0058 17.0 0.0 8.5 8 2 0 8 8 8 5 Ankyrin repeat PKcGMP_CC PF16808.5 EFO62335.1 - 0.016 15.0 0.8 8.6 6.3 0.1 2.9 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase PH_18 PF18469.1 EFO62335.1 - 0.089 12.8 1.2 0.69 9.9 0.4 2.8 3 0 0 3 3 3 0 Pleckstrin homology domain DUF641 PF04859.12 EFO62335.1 - 0.62 10.4 6.5 0.33 11.3 0.8 3.0 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) Ank_2 PF12796.7 EFO62336.1 - 6.4e-36 122.8 0.1 2.1e-09 37.8 0.0 5.5 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62336.1 - 5.6e-22 77.5 2.9 0.0012 19.1 0.0 8.3 6 1 3 9 9 9 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62336.1 - 4e-19 68.7 0.6 0.00096 19.7 0.0 5.1 5 1 1 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62336.1 - 1.7e-17 61.7 0.1 0.044 14.3 0.0 8.9 9 0 0 9 9 9 3 Ankyrin repeat Ank PF00023.30 EFO62336.1 - 7.5e-13 48.3 1.3 0.08 13.4 0.0 8.0 8 1 0 8 8 8 3 Ankyrin repeat CAP_GLY PF01302.25 EFO62337.1 - 5.7e-20 71.1 0.6 1.1e-19 70.2 0.6 1.5 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 EFO62337.1 - 0.046 14.2 16.5 16 6.1 0.1 5.9 5 1 2 7 7 7 0 Leucine Rich repeats (2 copies) Cylicin_N PF15241.6 EFO62337.1 - 0.066 13.3 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Cylicin N-terminus LRR_8 PF13855.6 EFO62337.1 - 1.5 8.6 15.9 11 5.8 3.3 4.7 5 1 0 5 5 5 0 Leucine rich repeat Proteasome PF00227.26 EFO62339.1 - 4.9e-38 130.5 0.3 5.6e-38 130.3 0.3 1.0 1 0 0 1 1 1 1 Proteasome subunit DUF4294 PF14127.6 EFO62339.1 - 0.019 14.9 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4294) Fe-ADH PF00465.19 EFO62339.1 - 0.086 11.6 0.1 0.28 9.9 0.0 1.7 2 0 0 2 2 2 0 Iron-containing alcohol dehydrogenase Ank_2 PF12796.7 EFO62340.1 - 1.4e-22 80.0 4.0 3.2e-10 40.4 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62340.1 - 1.7e-09 37.7 2.1 0.2 12.0 0.0 4.7 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62340.1 - 2.5e-08 33.5 1.8 6.7 7.6 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EFO62340.1 - 5.1e-07 29.8 0.1 0.58 10.7 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EFO62340.1 - 1.3e-06 28.9 1.1 0.1 13.2 0.0 3.7 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Rotamase PF00639.21 EFO62340.1 - 0.31 12.0 2.5 0.97 10.4 0.1 2.8 2 1 0 2 2 2 0 PPIC-type PPIASE domain Exonuc_VII_L PF02601.15 EFO62340.1 - 2.9 7.4 15.1 12 5.4 7.9 3.0 3 0 0 3 3 3 0 Exonuclease VII, large subunit TMPIT PF07851.13 EFO62340.1 - 4.1 6.6 14.1 0.14 11.4 3.6 2.7 3 0 0 3 3 3 0 TMPIT-like protein CENP-F_leu_zip PF10473.9 EFO62340.1 - 4.5 7.3 12.6 1.2 9.1 6.9 2.5 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Ank_2 PF12796.7 EFO62342.1 - 1.7e-71 236.8 18.9 2.2e-13 50.6 0.0 8.1 2 2 7 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62342.1 - 4.3e-40 135.6 8.0 2.4e-05 24.8 0.2 11.9 9 2 4 13 13 13 11 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62342.1 - 1.4e-34 117.7 15.7 4.4e-06 26.9 0.2 12.3 5 4 8 13 13 13 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62342.1 - 6.8e-34 112.1 13.4 0.025 15.1 0.0 13.5 15 0 0 15 15 15 8 Ankyrin repeat Ank PF00023.30 EFO62342.1 - 1.6e-30 104.1 13.4 0.0024 18.3 0.0 13.2 13 2 2 15 15 15 7 Ankyrin repeat RICTOR_M PF14666.6 EFO62343.1 - 1.6e-13 50.3 0.7 0.00014 21.6 0.0 5.7 4 1 1 5 5 5 4 Rapamycin-insensitive companion of mTOR, middle domain RasGEF_N_2 PF14663.6 EFO62343.1 - 1.6e-08 34.9 6.0 3.3e-08 33.9 0.1 4.0 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.6 EFO62343.1 - 0.015 15.5 1.8 5.4 7.3 0.0 4.9 5 0 0 5 5 5 0 Rapamycin-insensitive companion of mTOR, domain 5 Nmad5 PF18757.1 EFO62343.1 - 0.045 14.0 2.7 0.38 10.9 0.2 2.7 2 0 0 2 2 2 0 Nucleotide modification associated domain 5 Mycoplasma_p37 PF06646.11 EFO62343.1 - 0.061 12.6 0.8 0.14 11.3 0.8 1.6 1 0 0 1 1 1 0 High affinity transport system protein p37 DUF4199 PF13858.6 EFO62343.1 - 0.13 12.6 0.9 0.58 10.5 0.9 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) NPV_P10 PF05531.12 EFO62343.1 - 0.37 11.3 4.3 22 5.6 1.1 3.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein MORN PF02493.20 EFO62344.1 - 3.7e-80 259.3 81.6 1.8e-07 30.6 0.0 18.1 18 0 0 18 18 18 16 MORN repeat DUF3048_C PF17479.2 EFO62344.1 - 0.29 11.5 11.9 5.1 7.5 0.1 5.5 2 2 3 5 5 5 0 Protein of unknown function (DUF3048) C-terminal domain MVL PF12151.8 EFO62344.1 - 0.58 10.1 8.5 0.2 11.6 0.5 4.1 4 0 0 4 4 4 0 Mannan-binding protein DHH PF01368.20 EFO62348.1 - 3.1e-23 81.9 0.0 6.2e-23 81.0 0.0 1.5 1 1 0 1 1 1 1 DHH family CBS PF00571.28 EFO62348.1 - 1.7e-14 54.0 0.0 1.1e-06 28.9 0.0 2.9 2 0 0 2 2 2 2 CBS domain DHHA2 PF02833.14 EFO62348.1 - 4.4e-08 33.4 0.0 1e-07 32.2 0.0 1.7 1 0 0 1 1 1 1 DHHA2 domain Orthopox_F6 PF06601.12 EFO62348.1 - 0.074 13.2 0.0 7.2 6.8 0.0 2.9 2 0 0 2 2 2 0 Orthopoxvirus F6 protein UbiA PF01040.18 EFO62349.1 - 0.032 13.5 0.2 0.032 13.5 0.2 2.1 2 0 0 2 2 2 0 UbiA prenyltransferase family zf-H2C2_5 PF13909.6 EFO62349.1 - 0.1 12.4 0.1 0.23 11.3 0.1 1.6 1 0 0 1 1 1 0 C2H2-type zinc-finger domain Ank_2 PF12796.7 EFO62351.1 - 1.5e-21 76.8 4.6 1.6e-10 41.4 0.1 2.9 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFO62351.1 - 1.9e-14 53.3 2.1 0.0062 16.9 0.0 4.6 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 EFO62351.1 - 1e-13 50.1 1.3 0.07 13.7 0.0 4.7 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 EFO62351.1 - 5.2e-13 48.9 0.8 7e-05 23.0 0.2 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62351.1 - 8e-12 45.4 0.3 5e-05 23.8 0.1 4.2 3 1 1 4 4 4 4 Ankyrin repeats (many copies) DUF3102 PF11300.8 EFO62351.1 - 0.1 12.9 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3102) FKS1_dom1 PF14288.6 EFO62351.1 - 0.12 12.7 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 1,3-beta-glucan synthase subunit FKS1, domain-1 Vps35 PF03635.17 EFO62352.1 - 4.5e-43 147.8 12.9 1e-28 100.3 0.7 3.0 3 0 0 3 3 3 3 Vacuolar protein sorting-associated protein 35 PABP PF00658.18 EFO62352.1 - 0.019 15.1 0.0 0.23 11.7 0.0 2.6 3 0 0 3 3 3 0 Poly-adenylate binding protein, unique domain DcpS PF05652.12 EFO62352.1 - 0.07 14.0 0.0 5.8 7.8 0.0 2.8 2 0 0 2 2 2 0 Scavenger mRNA decapping enzyme (DcpS) N-terminal TMF_TATA_bd PF12325.8 EFO62354.1 - 0.016 15.5 5.7 0.016 15.5 5.7 3.9 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Mto2_bdg PF12808.7 EFO62354.1 - 0.043 14.1 0.7 0.043 14.1 0.7 5.3 5 1 0 5 5 5 0 Micro-tubular organiser Mto1 C-term Mto2-binding region GAS PF13851.6 EFO62354.1 - 0.13 11.6 34.7 0.072 12.4 16.4 3.3 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 EFO62354.1 - 0.27 11.7 40.6 0.04 14.4 5.2 3.6 3 1 1 4 4 4 0 Apg6 coiled-coil region Hemerythrin PF01814.23 EFO62354.1 - 1.6 9.3 5.5 12 6.5 0.5 3.2 2 1 1 3 3 3 0 Hemerythrin HHE cation binding domain FUSC PF04632.12 EFO62354.1 - 3.4 6.1 10.6 0.53 8.8 7.0 1.4 2 0 0 2 2 2 0 Fusaric acid resistance protein family Macoilin PF09726.9 EFO62354.1 - 8.4 4.8 30.2 3.8 5.9 10.1 2.6 1 1 1 2 2 2 0 Macoilin family HALZ PF02183.18 EFO62355.1 - 1 9.6 16.8 0.92 9.8 1.6 4.0 4 0 0 4 4 4 0 Homeobox associated leucine zipper DUF919 PF06034.11 EFO62355.1 - 4.2 7.3 6.9 0.45 10.4 0.3 2.8 3 0 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF919) Cnn_1N PF07989.11 EFO62355.1 - 5.3 7.3 23.6 1.1 9.4 2.8 4.8 3 1 1 4 4 4 0 Centrosomin N-terminal motif 1 Ank_2 PF12796.7 EFO62356.1 - 8.3e-42 141.7 2.8 4.5e-13 49.6 0.1 4.8 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62356.1 - 9.6e-25 86.3 3.2 0.0016 18.7 0.0 7.3 1 1 6 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO62356.1 - 5.7e-21 74.0 4.5 0.018 15.5 0.0 7.5 7 0 0 7 7 7 6 Ankyrin repeat Ank_3 PF13606.6 EFO62356.1 - 1.5e-20 71.1 4.9 0.3 11.8 0.0 8.2 8 0 0 8 8 8 6 Ankyrin repeat Ank_4 PF13637.6 EFO62356.1 - 6.3e-18 64.9 1.5 0.0017 18.9 0.1 5.8 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO62356.1 - 7.7e-17 61.5 0.0 7.7e-16 58.2 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62356.1 - 3e-13 49.7 0.0 4e-09 36.1 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFO62356.1 - 0.00025 20.5 0.0 0.00066 19.1 0.0 1.7 1 0 0 1 1 1 1 Kinase-like CbiM PF01891.16 EFO62356.1 - 0.032 14.1 0.0 0.07 13.0 0.0 1.5 1 0 0 1 1 1 0 Cobalt uptake substrate-specific transmembrane region tRNA-synt_1g PF09334.11 EFO62356.1 - 0.061 12.1 0.0 0.12 11.1 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (M) DNA_primase_lrg PF04104.14 EFO62357.1 - 8e-75 251.7 0.2 1.1e-74 251.2 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Vps16_N PF04841.13 EFO62359.1 - 0.074 11.8 0.0 0.13 11.0 0.0 1.4 1 1 0 1 1 1 0 Vps16, N-terminal region RVT_1 PF00078.27 EFO62360.1 - 2.6e-05 23.8 0.0 4e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Clat_adaptor_s PF01217.20 EFO62361.1 - 1.7e-30 105.8 0.4 1.9e-30 105.7 0.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain VSP PF03302.13 EFO62362.1 - 1.5e-157 524.5 188.0 8.9e-153 508.8 106.5 3.1 1 1 2 3 3 3 3 Giardia variant-specific surface protein SKG6 PF08693.10 EFO62362.1 - 0.071 12.5 3.7 0.14 11.5 3.7 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Podoplanin PF05808.11 EFO62362.1 - 3.6 7.7 4.4 7.1 6.7 3.1 2.1 1 1 0 1 1 1 0 Podoplanin GTP_EFTU PF00009.27 EFO62364.1 - 2.5e-35 121.8 0.1 4e-35 121.1 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFO62364.1 - 2e-09 37.7 0.0 4.7e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 EFO62364.1 - 0.00098 19.2 0.0 0.0049 16.9 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EFO62364.1 - 0.027 13.6 0.0 0.041 13.0 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit AAA_29 PF13555.6 EFO62364.1 - 0.073 12.8 0.4 0.19 11.5 0.4 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain PBP1_TM PF14812.6 EFO62364.1 - 1 9.8 8.0 2.2 8.7 8.0 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NUDE_C PF04880.13 EFO62364.1 - 2.7 8.4 6.3 4.7 7.7 6.3 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Rit1_C PF17184.4 EFO62365.1 - 1.1e-51 175.9 0.0 1.9e-51 175.1 0.0 1.4 1 0 0 1 1 1 1 Rit1 N-terminal domain SMODS PF18144.1 EFO62365.1 - 0.014 15.6 0.0 0.035 14.3 0.0 1.6 2 0 0 2 2 2 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain DUF1772 PF08592.11 EFO62366.1 - 0.28 11.5 0.1 0.28 11.5 0.1 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF1772) Pyrid_ox_like PF16242.5 EFO62367.1 - 6.4e-05 22.6 0.0 8.3e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 EFO62367.1 - 0.00017 21.7 0.0 0.00022 21.4 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase RIO1 PF01163.22 EFO62368.1 - 2.4e-38 131.6 0.7 8e-38 129.9 0.1 2.1 2 1 0 2 2 2 1 RIO1 family Rio2_N PF09202.11 EFO62368.1 - 1.2e-28 99.1 0.0 3.6e-28 97.6 0.0 1.9 2 0 0 2 2 2 1 Rio2, N-terminal Kdo PF06293.14 EFO62368.1 - 1.2e-05 24.8 0.3 0.00061 19.2 0.0 2.5 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFO62368.1 - 0.0015 18.5 0.0 0.1 12.5 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family VSP PF03302.13 EFO62369.1 - 3e-78 263.4 171.8 2e-75 254.1 90.3 4.5 1 1 1 3 3 3 2 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO62369.1 - 0.00027 21.1 17.1 0.00027 21.1 17.1 13.2 1 1 11 14 14 14 4 Furin-like repeat, cysteine-rich Peptidase_C13 PF01650.18 EFO62371.1 - 3.7e-14 52.9 0.1 3.1e-13 49.8 0.1 2.0 1 1 0 1 1 1 1 Peptidase C13 family Peptidase_C14 PF00656.22 EFO62371.1 - 0.088 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Caspase domain MatE PF01554.18 EFO62373.1 - 4.7e-24 84.9 23.9 7.6e-15 54.9 9.5 2.5 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 EFO62373.1 - 1.4e-06 28.4 3.5 1.4e-06 28.4 3.5 4.1 5 1 0 5 5 5 1 Polysaccharide biosynthesis C-terminal domain SAPS PF04499.15 EFO62376.1 - 0.0065 15.3 1.6 0.024 13.4 1.2 2.0 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein ubiquitin PF00240.23 EFO62378.1 - 4.1e-09 36.1 0.0 7.3e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family STI1 PF17830.1 EFO62378.1 - 4.5e-08 32.9 19.5 1.4e-05 24.9 4.2 4.9 4 1 1 5 5 5 2 STI1 domain GlnE PF03710.15 EFO62378.1 - 0.0066 15.9 1.6 1.5 8.2 0.2 2.3 2 0 0 2 2 2 2 Glutamate-ammonia ligase adenylyltransferase XPC-binding PF09280.11 EFO62378.1 - 0.0083 15.8 10.3 0.15 11.8 0.7 4.4 3 0 0 3 3 3 2 XPC-binding domain HBM PF16591.5 EFO62378.1 - 0.038 13.4 4.5 1 8.7 0.5 2.5 2 1 0 2 2 2 0 Helical bimodular sensor domain partial_CstF PF15861.5 EFO62378.1 - 0.1 12.4 0.1 0.76 9.6 0.0 2.6 2 0 0 2 2 2 0 Partial cleavage stimulation factor domain Mod_r PF07200.13 EFO62378.1 - 0.19 11.8 4.5 1.5 8.9 0.2 2.8 2 1 1 3 3 2 0 Modifier of rudimentary (Mod(r)) protein DUF2203 PF09969.9 EFO62378.1 - 0.22 12.3 0.2 2.9 8.6 0.0 2.3 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Kelch_5 PF13854.6 EFO62379.1 - 5.8e-13 48.5 0.0 6.5e-07 29.2 0.0 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 EFO62379.1 - 6.8e-13 48.4 0.1 0.00029 20.8 0.1 3.7 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EFO62379.1 - 5.9e-09 36.0 0.9 0.0043 17.3 0.0 3.6 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EFO62379.1 - 1.3e-08 34.8 0.5 0.035 14.4 0.0 4.6 5 1 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 EFO62379.1 - 6.1e-06 26.0 0.4 0.0022 17.9 0.1 3.3 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 EFO62379.1 - 2.9e-05 23.6 0.4 0.00091 18.8 0.2 3.2 3 1 0 3 3 3 1 Kelch motif Ank_2 PF12796.7 EFO62380.1 - 1.5e-46 156.9 10.8 4.2e-11 43.3 0.1 5.1 2 2 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62380.1 - 1.2e-24 86.3 5.5 1.7e-05 25.3 0.0 5.6 5 1 0 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO62380.1 - 2.9e-24 84.4 4.2 0.015 15.8 0.0 9.1 9 0 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 EFO62380.1 - 3.2e-24 84.7 8.1 0.00015 22.0 0.1 7.8 2 2 6 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62380.1 - 4.2e-23 78.9 6.5 0.036 14.6 0.1 9.3 9 0 0 9 9 9 5 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO62380.1 - 2.5e-10 40.0 20.4 5e-10 39.1 20.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO62380.1 - 0.91 9.4 19.4 1.7 8.6 19.4 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Mito_fiss_reg PF05308.11 EFO62381.1 - 0.009 16.1 4.7 0.018 15.1 4.7 1.5 1 0 0 1 1 1 1 Mitochondrial fission regulator DUF1664 PF07889.12 EFO62381.1 - 0.14 12.2 27.0 0.36 10.9 2.0 5.5 3 2 2 5 5 5 0 Protein of unknown function (DUF1664) RasGAP_C PF03836.15 EFO62381.1 - 0.18 11.9 15.7 0.49 10.5 0.2 4.5 1 1 2 3 3 3 0 RasGAP C-terminus DUF3130 PF11328.8 EFO62381.1 - 0.25 11.6 3.9 2.2 8.6 0.1 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF3130 Golgin_A5 PF09787.9 EFO62381.1 - 0.34 10.3 27.5 0.024 14.1 12.1 3.1 1 1 3 4 4 4 0 Golgin subfamily A member 5 Baculo_PEP_C PF04513.12 EFO62381.1 - 0.75 9.8 22.7 1.4 9.0 3.4 4.5 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus YtxH PF12732.7 EFO62381.1 - 1.3 9.6 7.6 11 6.6 0.1 4.4 3 3 0 3 3 3 0 YtxH-like protein DUF4094 PF13334.6 EFO62381.1 - 2.7 8.5 10.7 9.3 6.7 1.7 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4094) YojJ PF10372.9 EFO62381.1 - 4 7.6 10.8 36 4.5 0.0 5.2 3 2 3 6 6 6 0 Bacterial membrane-spanning protein N-terminus DUF2433 PF10360.9 EFO62381.1 - 7.4 6.7 10.4 28 4.8 2.0 4.1 1 1 3 4 4 4 0 Protein of unknown function (DUF2433) KxDL PF10241.9 EFO62381.1 - 8.7 6.7 14.0 6.2 7.2 1.9 4.4 2 2 1 3 3 3 0 Uncharacterized conserved protein SIR2 PF02146.17 EFO62382.1 - 8.6e-50 169.1 0.0 2.5e-49 167.6 0.0 1.7 1 1 0 1 1 1 1 Sir2 family SIR2 PF02146.17 EFO62383.1 - 7.2e-43 146.6 0.0 1.4e-42 145.6 0.0 1.5 1 0 0 1 1 1 1 Sir2 family T6SS_VipA PF05591.12 EFO62383.1 - 0.038 13.8 0.1 0.087 12.6 0.1 1.5 1 0 0 1 1 1 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 SPT16 PF08644.11 EFO62384.1 - 1e-10 42.0 0.1 1e-10 42.0 0.1 2.4 2 1 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) Rtt106 PF08512.12 EFO62384.1 - 7.5e-05 23.1 0.1 0.00026 21.3 0.1 1.9 1 0 0 1 1 1 1 Histone chaperone Rttp106-like Peptidase_M24 PF00557.24 EFO62384.1 - 0.051 13.3 0.0 0.16 11.7 0.0 1.9 2 0 0 2 2 2 0 Metallopeptidase family M24 Metallophos PF00149.28 EFO62385.1 - 8.9e-27 94.9 0.1 1.2e-26 94.5 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFO62385.1 - 0.0019 18.4 0.0 0.0029 17.8 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain SopA PF13981.6 EFO62385.1 - 0.041 14.3 0.1 0.12 12.8 0.1 1.8 2 0 0 2 2 2 0 SopA-like central domain WD40 PF00400.32 EFO62386.1 - 0.00019 22.1 3.7 1.1 10.3 0.5 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat GCP_C_terminal PF04130.13 EFO62387.1 - 1.1e-27 97.4 0.4 2.8e-27 96.0 0.4 1.7 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EFO62387.1 - 3e-23 82.9 0.7 3e-23 82.9 0.7 1.7 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal LAMTOR PF15454.6 EFO62387.1 - 0.023 15.3 1.1 0.077 13.6 0.6 2.1 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator BES1_N PF05687.13 EFO62387.1 - 0.026 14.9 0.1 0.026 14.9 0.1 2.2 1 1 1 2 2 2 0 BES1/BZR1 plant transcription factor, N-terminal EGF_2 PF07974.13 EFO62388.1 - 1.8e-10 41.0 25.1 1.5e-07 31.7 6.7 8.7 7 1 1 8 8 8 4 EGF-like domain EGF PF00008.27 EFO62388.1 - 1.6e-06 28.3 66.9 0.0055 17.0 2.7 9.2 6 5 1 7 7 7 5 EGF-like domain hEGF PF12661.7 EFO62388.1 - 0.012 16.2 16.7 0.017 15.7 6.7 9.2 8 0 0 8 8 8 0 Human growth factor-like EGF EGF_Tenascin PF18720.1 EFO62388.1 - 0.03 14.4 4.0 0.03 14.4 4.0 9.6 11 3 0 11 11 11 0 Tenascin EGF domain Brix PF04427.18 EFO62389.1 - 2e-26 93.3 0.0 2.6e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Brix domain Ribonuc_L-PSP PF01042.21 EFO62390.1 - 1.4e-18 67.0 0.0 1.8e-18 66.7 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP Corona_NS4 PF03905.13 EFO62390.1 - 0.0047 16.9 0.0 0.0088 16.0 0.0 1.4 1 0 0 1 1 1 1 Coronavirus non-structural protein NS4 VSP PF03302.13 EFO62392.1 - 2.5e-33 115.5 45.3 1.7e-25 89.7 8.5 2.1 1 1 1 2 2 2 2 Giardia variant-specific surface protein SKG6 PF08693.10 EFO62392.1 - 0.057 12.8 4.4 0.22 10.9 4.4 2.0 1 0 0 1 1 1 0 Transmembrane alpha-helix domain stn_TNFRSF12A PF12191.8 EFO62392.1 - 0.07 13.4 0.1 0.07 13.4 0.1 2.0 2 1 1 3 3 3 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Podoplanin PF05808.11 EFO62392.1 - 8.4 6.5 8.3 1.9 8.6 4.1 2.1 1 1 1 2 2 2 0 Podoplanin Tctex-1 PF03645.13 EFO62393.1 - 3.3e-14 53.0 0.0 3.8e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family CDP-OH_P_transf PF01066.21 EFO62394.1 - 9.9e-08 32.7 0.2 9.9e-08 32.7 0.2 4.6 4 2 0 4 4 4 1 CDP-alcohol phosphatidyltransferase DUF997 PF06196.12 EFO62394.1 - 7.7 6.6 11.6 0.52 10.4 0.1 4.1 3 1 0 3 3 3 0 Protein of unknown function (DUF997) HALZ PF02183.18 EFO62395.1 - 0.0019 18.4 3.6 0.94 9.7 0.4 3.4 2 0 0 2 2 2 2 Homeobox associated leucine zipper Fungal_TACC PF12709.7 EFO62395.1 - 0.052 14.0 2.3 0.052 14.0 2.3 4.4 4 1 0 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins Spc7 PF08317.11 EFO62395.1 - 0.11 11.3 30.5 0.089 11.7 10.0 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein NuA4 PF09340.10 EFO62395.1 - 0.54 10.2 5.9 1.9 8.4 0.2 3.2 3 1 0 3 3 3 0 Histone acetyltransferase subunit NuA4 DUF2951 PF11166.8 EFO62395.1 - 1.6 9.0 7.0 12 6.2 0.5 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2951) Tli4_C PF18426.1 EFO62395.1 - 6.3 7.1 9.5 3.8 7.8 1.9 2.9 2 1 0 2 2 2 0 Tle cognate immunity protein 4 C-terminal domain PCIF1_WW PF12237.8 EFO62396.1 - 1.1e-59 200.9 1.2 1.8e-59 200.2 1.2 1.3 1 0 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain KxDL PF10241.9 EFO62396.1 - 0.032 14.5 0.7 0.55 10.6 0.3 2.7 2 0 0 2 2 2 0 Uncharacterized conserved protein Utp11 PF03998.13 EFO62397.1 - 8.1e-23 81.6 11.2 2e-20 73.8 11.2 2.3 1 1 0 1 1 1 1 Utp11 protein IQ PF00612.27 EFO62398.1 - 0.47 10.4 4.9 0.36 10.8 0.8 2.7 2 0 0 2 2 2 0 IQ calmodulin-binding motif DUF1325 PF07039.11 EFO62400.1 - 2.4e-12 47.1 0.1 2.7e-12 46.9 0.1 1.1 1 0 0 1 1 1 1 SGF29 tudor-like domain DUF4537 PF15057.6 EFO62400.1 - 0.028 14.4 0.1 0.032 14.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) Epimerase PF01370.21 EFO62402.1 - 9.6e-24 84.2 0.0 1.3e-23 83.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFO62402.1 - 6.2e-14 52.1 0.0 7.5e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EFO62402.1 - 9.3e-12 44.6 0.0 1.5e-11 43.9 0.0 1.3 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 EFO62402.1 - 6.2e-11 41.8 0.0 9.7e-11 41.2 0.0 1.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFO62402.1 - 2.1e-08 33.7 1.4 3.3e-07 29.7 1.4 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EFO62402.1 - 2.5e-08 34.0 0.0 3.6e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EFO62402.1 - 4.4e-08 33.3 0.1 7.4e-08 32.5 0.1 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFO62402.1 - 1.4e-07 31.0 0.0 9.4e-05 21.7 0.0 2.1 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein adh_short PF00106.25 EFO62402.1 - 1.5e-06 27.8 0.0 3.3e-06 26.7 0.0 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFO62402.1 - 0.014 14.9 0.0 0.023 14.3 0.0 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase NmrA PF05368.13 EFO62402.1 - 0.03 13.9 0.0 0.1 12.1 0.0 1.8 2 0 0 2 2 2 0 NmrA-like family Aminotran_4 PF01063.19 EFO62403.1 - 1.2e-31 110.4 0.0 1.4e-31 110.1 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV DeoC PF01791.9 EFO62404.1 - 4e-20 72.4 2.6 5e-20 72.1 2.6 1.0 1 0 0 1 1 1 1 DeoC/LacD family aldolase His_biosynth PF00977.21 EFO62404.1 - 0.014 14.9 0.2 0.026 14.0 0.2 1.4 1 0 0 1 1 1 0 Histidine biosynthesis protein DER1 PF04511.15 EFO62406.1 - 3.1e-36 125.1 14.4 3.7e-36 124.9 14.4 1.0 1 0 0 1 1 1 1 Der1-like family Peptidase_C50 PF03568.17 EFO62408.1 - 1.2e-17 64.2 0.0 4.1e-14 52.5 0.0 2.5 2 0 0 2 2 2 2 Peptidase family C50 MRG PF05712.13 EFO62409.1 - 7.8e-11 41.7 3.0 1.6e-10 40.7 3.0 1.5 1 1 0 1 1 1 1 MRG Robl_LC7 PF03259.17 EFO62410.1 - 1.1e-19 70.0 0.0 1.2e-19 69.9 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain Kinesin PF00225.23 EFO62413.1 - 2e-91 306.4 0.0 4e-91 305.4 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFO62413.1 - 1.2e-25 90.2 0.0 4.7e-25 88.3 0.0 2.0 1 0 0 1 1 1 1 Microtubule binding TSC22 PF01166.18 EFO62413.1 - 0.49 10.7 5.6 6.1 7.2 0.3 3.5 2 1 1 3 3 3 0 TSC-22/dip/bun family AATF-Che1 PF13339.6 EFO62414.1 - 1.4e-05 25.8 0.8 6.9e-05 23.6 0.8 2.2 1 1 0 1 1 1 1 Apoptosis antagonizing transcription factor TRAUB PF08164.12 EFO62414.1 - 0.02 15.4 0.5 0.02 15.4 0.5 1.9 2 0 0 2 2 2 0 Apoptosis-antagonizing transcription factor, C-terminal DUF1003 PF06210.11 EFO62414.1 - 0.18 11.9 0.0 0.4 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) VSP PF03302.13 EFO62415.1 - 1e-36 126.6 211.2 1.2e-18 67.2 10.8 6.6 1 1 5 6 6 6 5 Giardia variant-specific surface protein SKG6 PF08693.10 EFO62415.1 - 1.2 8.6 5.6 2.4 7.6 5.6 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Torus PF16131.5 EFO62417.1 - 5.2e-13 49.6 0.2 8.2e-13 49.0 0.2 1.3 1 0 0 1 1 1 1 Torus domain zf-CCCH PF00642.24 EFO62417.1 - 0.00021 21.1 1.4 0.00047 20.0 0.3 2.1 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFO62417.1 - 0.17 12.0 4.8 0.22 11.6 1.5 2.4 2 0 0 2 2 2 0 Zinc finger domain GDPD PF03009.17 EFO62418.1 - 1.1e-24 87.5 0.0 2.3e-24 86.6 0.0 1.4 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 EFO62419.1 - 2.9e-79 261.7 7.8 4.9e-10 39.9 0.0 9.1 2 1 6 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62419.1 - 4e-44 148.4 10.4 3.7e-09 36.9 0.4 12.1 7 4 8 15 15 15 11 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62419.1 - 2.6e-43 145.5 15.5 1.1e-06 28.7 0.2 12.3 6 4 8 14 14 14 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62419.1 - 5.7e-41 133.8 12.2 0.0038 17.6 0.2 16.1 18 0 0 18 18 18 11 Ankyrin repeat Ank PF00023.30 EFO62419.1 - 5.4e-33 112.0 14.3 0.019 15.4 0.2 15.9 14 2 1 15 15 15 8 Ankyrin repeat Prok-RING_4 PF14447.6 EFO62419.1 - 0.049 13.5 9.1 0.098 12.5 9.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFO62419.1 - 1.4 9.3 7.1 2.9 8.3 7.1 1.5 1 0 0 1 1 1 0 Ring finger domain Cadherin_C_2 PF16492.5 EFO62420.1 - 0.012 16.4 0.2 0.014 16.1 0.2 1.1 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal Pkinase PF00069.25 EFO62421.1 - 1.7e-38 132.5 0.0 5.5e-38 130.8 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62421.1 - 3.4e-25 88.8 0.0 4.2e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO62421.1 - 3.7e-07 29.8 0.0 2.6e-06 27.0 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Rad21_Rec8 PF04824.16 EFO62422.1 - 0.00088 18.5 0.1 0.0049 16.1 0.0 2.2 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein Ank_2 PF12796.7 EFO62423.1 - 6.3e-73 241.4 31.3 1.3e-09 38.4 0.3 11.2 4 3 7 11 11 11 11 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62423.1 - 7.5e-42 141.2 22.7 3.4e-06 27.5 0.3 13.4 11 3 4 15 15 15 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62423.1 - 2.2e-35 120.2 23.3 6.2e-06 26.4 0.0 12.7 6 2 7 14 14 14 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62423.1 - 4.8e-31 103.3 27.1 0.013 15.9 0.0 16.9 18 0 0 18 18 18 9 Ankyrin repeat Ank PF00023.30 EFO62423.1 - 5.4e-26 89.9 30.0 0.0088 16.4 0.0 16.1 14 3 0 14 14 14 6 Ankyrin repeat RNase_HII PF01351.18 EFO62424.1 - 1.4e-36 126.3 0.0 1.9e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease HII ApoO PF09769.9 EFO62425.1 - 0.0012 18.8 3.3 0.3 11.0 0.2 2.9 2 0 0 2 2 2 2 Apolipoprotein O Tup_N PF08581.10 EFO62425.1 - 0.032 14.5 0.3 0.032 14.5 0.3 4.6 3 1 1 4 4 4 0 Tup N-terminal Acyl-CoA_dh_2 PF08028.11 EFO62425.1 - 0.42 10.9 6.3 0.68 10.2 4.7 2.3 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain TPR_MLP1_2 PF07926.12 EFO62425.1 - 0.69 10.0 40.9 0.033 14.3 12.0 4.4 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.12 EFO62425.1 - 0.95 9.5 20.6 1.4 9.0 1.0 4.8 2 2 3 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.18 EFO62425.1 - 1.3 8.8 40.8 9.7 6.0 34.0 3.6 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF3584 PF12128.8 EFO62425.1 - 1.9 5.9 39.0 0.6 7.5 9.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) MRP-S31 PF15433.6 EFO62425.1 - 3.4 7.2 18.2 0.033 13.9 9.3 2.2 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S31 GAS PF13851.6 EFO62425.1 - 4.1 6.7 40.5 0.079 12.3 5.6 3.1 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Lebercilin PF15619.6 EFO62426.1 - 7e-06 25.8 0.9 1.4e-05 24.9 0.2 1.7 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease CdvA PF18822.1 EFO62426.1 - 0.00039 20.2 1.2 0.32 10.8 2.2 3.5 2 1 1 3 3 3 1 CdvA-like coiled-coil domain Baculo_PEP_C PF04513.12 EFO62426.1 - 0.0011 19.0 0.0 0.0017 18.4 0.0 1.2 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 EFO62426.1 - 0.0049 15.8 0.9 0.0063 15.4 0.9 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein eIF-3c_N PF05470.12 EFO62426.1 - 0.0051 15.2 0.5 0.0057 15.0 0.5 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Tup_N PF08581.10 EFO62426.1 - 0.019 15.2 1.1 0.048 14.0 1.1 1.6 1 0 0 1 1 1 0 Tup N-terminal SseC PF04888.12 EFO62426.1 - 0.019 14.5 0.4 0.067 12.8 0.1 1.7 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family EF-G-binding_N PF07299.11 EFO62426.1 - 0.02 15.4 1.4 0.12 12.9 0.8 2.1 1 1 1 2 2 2 0 Elongation factor G-binding protein, N-terminal Prefoldin_2 PF01920.20 EFO62426.1 - 0.02 14.8 1.7 0.22 11.5 0.6 2.2 2 0 0 2 2 2 0 Prefoldin subunit DHR10 PF18595.1 EFO62426.1 - 0.032 14.3 1.8 0.063 13.3 0.3 1.9 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Occludin_ELL PF07303.13 EFO62426.1 - 0.041 14.6 3.4 0.2 12.4 0.8 2.2 2 0 0 2 2 2 0 Occludin homology domain TMPIT PF07851.13 EFO62426.1 - 0.06 12.6 0.5 0.06 12.6 0.5 1.4 2 0 0 2 2 2 0 TMPIT-like protein SbsC_C PF18058.1 EFO62426.1 - 0.061 13.5 1.5 0.38 11.0 0.0 2.1 1 1 1 2 2 2 0 SbsC C-terminal domain LPD34 PF18852.1 EFO62426.1 - 0.062 12.9 2.0 0.21 11.2 0.1 2.0 1 1 1 2 2 2 0 Large polyvalent protein associated domain 34 CENP-F_leu_zip PF10473.9 EFO62426.1 - 0.065 13.3 2.0 0.11 12.5 2.0 1.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KxDL PF10241.9 EFO62426.1 - 0.081 13.2 1.0 13 6.1 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein Syntaxin PF00804.25 EFO62426.1 - 0.088 12.5 0.1 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 Syntaxin DUF2115 PF09888.9 EFO62426.1 - 0.11 13.0 2.1 0.15 12.5 2.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) CREPT PF16566.5 EFO62426.1 - 0.11 12.6 0.9 0.23 11.6 0.6 1.5 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour HsbA PF12296.8 EFO62426.1 - 0.17 12.3 0.1 0.28 11.6 0.1 1.5 1 1 0 1 1 1 0 Hydrophobic surface binding protein A BLOC1_2 PF10046.9 EFO62426.1 - 0.28 11.5 4.0 0.64 10.4 2.0 2.1 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ATG16 PF08614.11 EFO62426.1 - 0.38 10.9 4.7 1.7 8.8 4.7 1.8 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) HSCB_C PF07743.13 EFO62426.1 - 0.4 11.2 2.6 17 6.0 0.4 2.2 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain DSPc PF00782.20 EFO62427.1 - 4.6e-19 68.6 0.0 6.4e-19 68.1 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFO62427.1 - 0.1 12.1 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PI3_PI4_kinase PF00454.27 EFO62428.1 - 2.5e-40 138.9 0.4 7.7e-40 137.3 0.4 1.9 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFO62428.1 - 1.1e-17 64.0 2.3 2.2e-17 63.1 0.7 2.3 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 EFO62428.1 - 0.1 12.5 0.1 3.1 7.7 0.0 2.8 2 1 0 2 2 2 0 Phosphoinositide 3-kinase C2 SRP54 PF00448.22 EFO62429.1 - 5.6e-46 156.6 0.0 9e-46 156.0 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 EFO62429.1 - 4.8e-06 26.7 1.9 4.8e-06 26.7 1.9 2.0 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain CbiA PF01656.23 EFO62429.1 - 0.00021 21.3 0.0 0.0043 17.1 0.0 2.4 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain MeaB PF03308.16 EFO62429.1 - 0.00023 20.3 0.0 0.00055 19.0 0.0 1.6 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 EFO62429.1 - 0.0044 16.8 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFO62429.1 - 0.0069 16.7 0.0 0.029 14.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFO62429.1 - 0.017 15.5 0.0 0.052 13.9 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 EFO62429.1 - 0.025 14.3 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EFO62429.1 - 0.026 14.5 0.1 0.072 13.0 0.1 1.9 1 1 0 1 1 1 0 NTPase DUF4801 PF16059.5 EFO62429.1 - 0.036 14.0 0.1 0.07 13.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4801) MobB PF03205.14 EFO62429.1 - 0.057 13.3 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_31 PF13614.6 EFO62429.1 - 0.084 12.8 4.0 0.38 10.6 0.1 3.2 2 1 1 3 3 3 0 AAA domain AAA_22 PF13401.6 EFO62429.1 - 0.12 12.6 2.3 0.15 12.3 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFO62429.1 - 0.16 12.1 0.3 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Exo_endo_phos PF03372.23 EFO62430.1 - 7.4e-07 28.9 0.0 2.4e-06 27.2 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF1206 PF06724.11 EFO62431.1 - 0.34 11.0 2.8 1.2 9.3 0.1 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1206) EMP24_GP25L PF01105.24 EFO62432.1 - 3.3e-21 76.1 0.0 4.3e-21 75.7 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Ank_2 PF12796.7 EFO62434.1 - 5e-43 145.6 12.0 1.5e-12 47.9 0.2 5.6 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62434.1 - 4.3e-34 116.1 11.7 4.1e-07 30.2 0.0 7.0 5 1 2 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO62434.1 - 9.3e-25 85.9 6.0 0.00096 19.5 0.0 7.5 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.6 EFO62434.1 - 6.2e-20 69.2 3.6 0.0022 18.3 0.0 9.4 9 0 0 9 9 9 4 Ankyrin repeat Ank_4 PF13637.6 EFO62434.1 - 8.1e-17 61.4 5.5 1.2e-08 35.3 0.0 6.1 3 2 4 7 7 7 4 Ankyrin repeats (many copies) HAD_2 PF13419.6 EFO62434.1 - 0.36 10.9 9.3 0.4 10.7 7.3 2.1 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase HALZ PF02183.18 EFO62434.1 - 4.3 7.6 20.0 2.8 8.2 0.9 6.2 6 0 0 6 6 6 0 Homeobox associated leucine zipper Ank_2 PF12796.7 EFO62435.1 - 5.7e-14 52.5 0.1 5.3e-07 30.1 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62435.1 - 2.1e-06 27.9 0.1 0.0085 16.4 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO62435.1 - 0.00094 19.5 0.8 24 5.6 0.0 4.6 4 1 0 4 4 4 0 Ankyrin repeat Ank_3 PF13606.6 EFO62435.1 - 0.0032 17.8 1.6 12 6.9 0.0 4.9 5 0 0 5 5 5 0 Ankyrin repeat PriA_3primeBD PF17764.1 EFO62435.1 - 0.004 17.0 0.1 0.057 13.3 0.0 2.6 2 0 0 2 2 2 1 3′ DNA-binding domain (3′BD) DUF3450 PF11932.8 EFO62435.1 - 0.03 13.6 0.1 0.03 13.6 0.1 3.0 3 1 0 3 3 2 0 Protein of unknown function (DUF3450) Phage_GP20 PF06810.11 EFO62435.1 - 0.04 13.7 3.1 0.27 11.1 0.6 2.7 2 0 0 2 2 2 0 Phage minor structural protein GP20 DUF4600 PF15372.6 EFO62435.1 - 0.078 13.4 7.2 0.11 12.9 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) Ank_4 PF13637.6 EFO62435.1 - 0.14 12.8 0.5 26 5.5 0.0 3.5 3 1 1 4 4 4 0 Ankyrin repeats (many copies) Sec2p PF06428.11 EFO62435.1 - 0.15 12.1 12.2 10 6.2 0.4 3.9 2 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p DUF1664 PF07889.12 EFO62435.1 - 0.34 11.0 8.8 0.13 12.4 1.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 EFO62435.1 - 0.66 10.1 12.2 0.3 11.3 0.6 3.5 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Cnn_1N PF07989.11 EFO62435.1 - 0.76 10.0 11.2 0.2 11.8 0.3 3.5 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 BLOC1_2 PF10046.9 EFO62435.1 - 1.9 8.8 13.2 0.62 10.4 1.7 3.6 2 2 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CCDC-167 PF15188.6 EFO62435.1 - 3.5 8.0 10.8 50 4.3 7.3 3.7 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 Spc42p PF11544.8 EFO62435.1 - 5.5 7.1 7.7 3.4 7.7 0.1 3.2 3 0 0 3 3 3 0 Spindle pole body component Spc42p Laminin_II PF06009.12 EFO62435.1 - 5.8 6.9 9.4 0.84 9.6 1.1 3.2 2 1 1 3 3 3 0 Laminin Domain II DUF16 PF01519.16 EFO62435.1 - 6.3 7.3 7.9 9.7 6.7 0.3 3.4 2 1 0 2 2 2 0 Protein of unknown function DUF16 PNP_UDP_1 PF01048.20 EFO62436.1 - 2.6e-51 174.1 0.6 3.1e-51 173.9 0.6 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Endotoxin_mid PF09131.10 EFO62436.1 - 0.076 12.7 0.0 0.21 11.3 0.0 1.6 2 0 0 2 2 2 0 Bacillus thuringiensis delta-Endotoxin, middle domain ATG16 PF08614.11 EFO62437.1 - 0.0045 17.2 3.9 0.0073 16.6 3.9 1.3 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) Pox_F17 PF04767.12 EFO62437.1 - 0.0066 16.9 0.9 0.013 16.0 0.9 1.5 1 0 0 1 1 1 1 DNA-binding 11 kDa phosphoprotein DUF641 PF04859.12 EFO62437.1 - 0.032 14.6 0.1 0.047 14.0 0.1 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) MAGE_N PF12440.8 EFO62437.1 - 0.08 13.6 2.5 0.12 13.1 2.5 1.3 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal UPF0020 PF01170.18 EFO62439.1 - 7.4e-10 38.8 0.1 7.1e-08 32.4 0.1 2.2 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 EFO62439.1 - 0.0036 17.0 0.1 0.18 11.5 0.0 2.2 2 0 0 2 2 2 1 DNA methylase tify PF06200.14 EFO62439.1 - 0.021 14.1 0.0 0.049 13.0 0.0 1.6 1 0 0 1 1 1 0 tify domain MethyltransfD12 PF02086.15 EFO62439.1 - 0.15 11.7 0.1 2.1 8.0 0.0 2.2 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase Metallophos PF00149.28 EFO62440.1 - 2.2e-21 77.3 0.3 3.2e-21 76.8 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFO62440.1 - 0.0011 19.2 0.1 0.0033 17.6 0.0 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Phospholip_B PF04916.13 EFO62442.1 - 1.3e-104 350.7 3.5 1.6e-104 350.4 3.5 1.0 1 0 0 1 1 1 1 Phospholipase B Arf PF00025.21 EFO62443.1 - 8.4e-13 48.1 0.3 1.6e-12 47.3 0.1 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFO62443.1 - 2e-06 27.4 0.1 7.1e-06 25.6 0.1 1.9 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EFO62443.1 - 1.3e-05 25.4 0.0 3e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFO62443.1 - 3.5e-05 23.5 0.1 3.5e-05 23.5 0.1 1.5 2 0 0 2 2 2 1 Ras family FeoB_N PF02421.18 EFO62443.1 - 0.00094 18.7 1.1 0.0019 17.8 0.9 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EFO62443.1 - 0.0012 18.9 0.5 0.0023 18.0 0.2 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EFO62443.1 - 0.0048 16.1 6.6 0.006 15.8 0.0 3.0 2 2 1 3 3 3 1 G-protein alpha subunit 6PF2K PF01591.18 EFO62443.1 - 0.0076 15.6 0.1 0.015 14.6 0.1 1.5 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AIG1 PF04548.16 EFO62443.1 - 0.066 12.5 3.0 0.085 12.2 0.3 2.2 2 0 0 2 2 2 0 AIG1 family Radial_spoke PF04712.12 EFO62444.1 - 0.00014 21.0 6.7 0.1 11.5 5.8 2.7 2 1 0 2 2 2 2 Radial spokehead-like protein CobT PF06213.12 EFO62444.1 - 0.031 13.7 2.6 0.046 13.1 2.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pro-rich_19 PF15455.6 EFO62444.1 - 0.16 11.1 1.4 0.29 10.2 1.4 1.3 2 0 0 2 2 2 0 Proline-rich 19 GEN1_C PF18380.1 EFO62444.1 - 0.26 12.2 4.3 0.43 11.5 4.3 1.2 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain Cnd2 PF05786.14 EFO62444.1 - 0.27 9.8 3.1 0.36 9.4 3.1 1.0 1 0 0 1 1 1 0 Condensin complex subunit 2 Roughex PF06020.11 EFO62444.1 - 6.6 5.7 7.3 9.3 5.2 7.3 1.1 1 0 0 1 1 1 0 Drosophila roughex protein DUF61 PF01886.16 EFO62445.1 - 0.042 13.9 0.0 0.7 9.9 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF61 VSP PF03302.13 EFO62446.1 - 1.6e-85 287.4 167.7 1.6e-41 142.5 33.1 4.6 1 1 4 5 5 5 4 Giardia variant-specific surface protein SKG6 PF08693.10 EFO62446.1 - 0.44 10.0 4.5 0.77 9.2 4.5 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Podoplanin PF05808.11 EFO62446.1 - 0.46 10.6 5.4 0.32 11.1 1.4 2.5 3 0 0 3 3 3 0 Podoplanin Dus PF01207.17 EFO62447.1 - 6.8e-36 123.9 0.0 1.8e-29 102.8 0.0 2.1 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH PF00642.24 EFO62447.1 - 0.23 11.4 3.2 0.23 11.5 0.5 2.4 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) JCAD PF15351.6 EFO62448.1 - 0.36 8.5 1.1 0.49 8.1 1.1 1.1 1 0 0 1 1 1 0 Junctional protein associated with coronary artery disease zf-rbx1 PF12678.7 EFO62451.1 - 5.5e-09 36.2 0.2 1.7e-08 34.6 0.2 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EFO62451.1 - 2.7e-07 30.8 4.1 6e-07 29.7 0.4 3.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFO62451.1 - 1.1e-06 28.4 4.8 2.9e-06 27.0 0.9 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFO62451.1 - 4.4e-06 26.5 2.6 4.9e-05 23.1 0.2 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFO62451.1 - 0.00014 21.6 4.2 0.00092 18.9 0.1 2.7 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EFO62451.1 - 0.00033 20.6 5.5 0.0058 16.6 0.4 3.5 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFO62451.1 - 0.00041 20.3 0.8 0.0012 18.7 0.0 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EFO62451.1 - 0.00042 20.3 1.6 0.0016 18.4 0.1 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EFO62451.1 - 0.027 14.3 0.1 0.084 12.8 0.1 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EFO62451.1 - 0.033 14.1 2.8 0.068 13.0 0.1 2.7 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 EFO62451.1 - 0.14 12.3 0.7 0.52 10.5 0.7 2.0 1 0 0 1 1 1 0 RING-variant domain zf-MYST PF17772.1 EFO62451.1 - 0.28 10.8 1.7 0.36 10.5 0.1 2.0 2 0 0 2 2 2 0 MYST family zinc finger domain Zn_ribbon_17 PF17120.5 EFO62451.1 - 1.6 8.4 5.8 2.6 7.7 0.5 2.9 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type PhoLip_ATPase_C PF16212.5 EFO62452.1 - 5.3e-35 121.4 37.6 5.3e-35 121.4 37.6 2.5 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFO62452.1 - 2.5e-11 43.1 1.0 2.5e-11 43.1 1.0 2.4 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EFO62452.1 - 8.3e-09 35.2 0.0 8.3e-09 35.2 0.0 3.4 3 1 1 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 EFO62452.1 - 8.8e-07 29.4 0.1 0.0036 17.6 0.0 3.3 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFO62452.1 - 0.0015 18.3 1.0 0.049 13.4 0.1 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFO62452.1 - 0.085 13.3 0.0 7.7 6.9 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Fic_N PF13784.6 EFO62454.1 - 0.13 12.3 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 Fic/DOC family N-terminal Phage_holin_4_1 PF05105.12 EFO62454.1 - 1.1 9.4 7.9 27 5.0 3.9 3.2 2 1 1 3 3 3 0 Bacteriophage holin family Ank_2 PF12796.7 EFO62455.1 - 8.3e-51 170.5 6.6 1.5e-16 60.8 0.1 4.9 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62455.1 - 1e-28 99.3 7.7 0.0002 21.8 0.2 7.7 5 2 2 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62455.1 - 2.6e-24 85.0 11.1 0.011 16.0 0.0 8.7 2 2 6 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.30 EFO62455.1 - 4.3e-23 80.7 5.3 0.0015 18.8 0.0 9.2 8 1 1 9 9 9 6 Ankyrin repeat Ank_3 PF13606.6 EFO62455.1 - 8.8e-23 77.9 4.1 0.16 12.7 0.0 9.6 9 0 0 9 9 9 4 Ankyrin repeat Scaffolding_pro PF11418.8 EFO62455.1 - 0.0058 17.2 0.6 0.0058 17.2 0.6 2.9 2 0 0 2 2 2 1 Phi29 scaffolding protein Fez1 PF06818.15 EFO62455.1 - 2.5 8.5 52.2 2.6 8.5 8.0 4.0 1 1 3 4 4 4 0 Fez1 ATG16 PF08614.11 EFO62455.1 - 6 7.0 52.6 1.5 9.0 17.9 3.7 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) DUF501 PF04417.12 EFO62455.1 - 7.2 6.4 11.4 10 5.9 0.2 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF501) TMF_TATA_bd PF12325.8 EFO62455.1 - 8.2 6.7 57.4 0.11 12.7 11.4 5.6 1 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding Filament PF00038.21 EFO62455.1 - 9.8 5.7 54.6 17 4.9 52.4 2.2 1 1 1 2 2 2 0 Intermediate filament protein FGGY_N PF00370.21 EFO62456.1 - 3.8e-61 206.7 0.2 5.5e-61 206.2 0.2 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 EFO62456.1 - 5.8e-36 124.1 0.0 1.9e-35 122.4 0.0 1.9 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Dynein_C PF18199.1 EFO62457.1 - 3.4e-95 318.8 0.2 3.9e-95 318.6 0.2 1.0 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 EFO62457.1 - 8.3e-15 55.0 0.0 1.5e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Ribo_biogen_C PF04034.13 EFO62458.1 - 2.6e-45 153.3 0.0 4.5e-45 152.5 0.0 1.4 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EFO62458.1 - 3.1e-05 23.7 0.5 5.7e-05 22.8 0.5 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Ank_2 PF12796.7 EFO62459.1 - 2.1e-58 194.8 8.5 6.8e-12 45.8 0.0 5.3 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62459.1 - 1.5e-35 121.1 8.6 1.5e-09 38.2 0.0 8.0 4 1 5 9 9 9 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62459.1 - 7.9e-33 112.1 10.5 0.00027 21.2 0.0 8.9 3 2 6 9 9 9 9 Ankyrin repeats (many copies) Ank PF00023.30 EFO62459.1 - 2.2e-29 100.5 8.4 0.036 14.5 0.0 9.7 8 1 1 9 9 9 8 Ankyrin repeat Ank_3 PF13606.6 EFO62459.1 - 7.7e-24 81.2 3.6 0.36 11.5 0.0 10.3 10 0 0 10 10 10 5 Ankyrin repeat ABC_tran PF00005.27 EFO62460.1 - 5.3e-25 88.5 0.0 1.1e-24 87.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EFO62460.1 - 1.6e-15 57.1 14.9 1.6e-15 57.1 14.9 1.4 2 0 0 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.6 EFO62460.1 - 1.2e-08 35.2 0.1 9.7e-06 25.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 EFO62460.1 - 0.014 15.3 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain ECF_trnsprt PF12822.7 EFO62460.1 - 4.2 7.4 17.1 0.18 11.9 9.5 2.5 2 1 1 3 3 3 0 ECF transporter, substrate-specific component Ank_2 PF12796.7 EFO62461.1 - 6.6e-34 116.4 4.4 2.7e-08 34.3 0.2 6.0 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62461.1 - 4.1e-22 78.0 4.8 4.4e-05 23.7 0.0 7.2 5 1 2 7 7 7 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62461.1 - 1.7e-18 66.7 7.8 0.028 15.0 0.0 8.0 6 2 1 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62461.1 - 1.2e-16 59.0 10.0 0.13 12.9 0.1 10.1 10 0 0 10 10 10 5 Ankyrin repeat Ank PF00023.30 EFO62461.1 - 7.2e-12 45.2 8.6 0.048 14.1 0.0 7.8 6 2 1 7 7 7 3 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO62461.1 - 1.3e-10 40.9 10.1 1.3e-10 40.9 10.1 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO62461.1 - 0.014 15.2 10.5 0.014 15.2 10.5 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 CD225 PF04505.12 EFO62461.1 - 0.12 12.6 0.5 26 5.0 0.0 3.0 3 0 0 3 3 3 0 Interferon-induced transmembrane protein zf-RING_5 PF14634.6 EFO62461.1 - 0.16 12.0 10.1 0.38 10.8 10.1 1.6 1 0 0 1 1 1 0 zinc-RING finger domain DEAD PF00270.29 EFO62462.1 - 1.4e-41 142.2 0.0 6e-41 140.1 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO62462.1 - 4e-27 94.8 0.0 1e-26 93.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EFO62462.1 - 0.00016 21.0 0.0 0.00037 19.8 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 EFO62462.1 - 0.00027 21.0 0.0 0.00085 19.4 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DBP10CT PF08147.12 EFO62462.1 - 0.089 13.1 3.1 0.22 11.8 3.1 1.7 1 0 0 1 1 1 0 DBP10CT (NUC160) domain gpUL132 PF11359.8 EFO62464.1 - 0.59 9.6 7.4 2.4 7.6 0.1 2.3 1 1 0 2 2 2 0 Glycoprotein UL132 Fez1 PF06818.15 EFO62465.1 - 0.0075 16.7 11.7 0.0075 16.7 11.7 1.9 1 1 1 2 2 2 1 Fez1 RapA_C PF12137.8 EFO62465.1 - 0.0093 15.0 9.9 0.018 14.1 9.9 1.5 1 0 0 1 1 1 1 RNA polymerase recycling family C-terminal KASH_CCD PF14662.6 EFO62465.1 - 0.053 13.3 17.7 0.13 12.0 17.7 1.6 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH CENP-F_N PF10481.9 EFO62465.1 - 0.11 12.1 18.1 0.18 11.4 18.1 1.2 1 0 0 1 1 1 0 Cenp-F N-terminal domain ATG16 PF08614.11 EFO62465.1 - 0.65 10.2 24.2 1.7 8.8 23.2 1.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF745 PF05335.13 EFO62465.1 - 0.9 9.2 19.2 0.84 9.3 5.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Cortex-I_coil PF09304.10 EFO62465.1 - 2.4 8.4 18.2 0.69 10.2 13.6 2.5 2 1 1 3 3 3 0 Cortexillin I, coiled coil MAD PF05557.13 EFO62465.1 - 2.8 6.2 20.9 4.4 5.6 20.9 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein FPP PF05911.11 EFO62465.1 - 5.4 5.1 21.0 8.2 4.5 21.0 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil FapA PF03961.13 EFO62465.1 - 5.6 5.5 8.3 8.1 4.9 8.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A HSP90 PF00183.18 EFO62466.1 - 1e-116 390.9 6.7 1.1e-116 390.8 6.7 1.0 1 0 0 1 1 1 1 Hsp90 protein Vma12 PF11712.8 EFO62467.1 - 0.34 11.0 0.1 0.34 11.0 0.1 2.2 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase RRP36 PF06102.12 EFO62468.1 - 3.4e-17 62.9 11.9 4.7e-17 62.4 11.9 1.1 1 0 0 1 1 1 1 rRNA biogenesis protein RRP36 Dus PF01207.17 EFO62469.1 - 7.3e-41 140.3 0.0 9.8e-41 139.8 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) ABC_tran PF00005.27 EFO62471.1 - 2.1e-25 89.8 0.0 4.2e-25 88.9 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EFO62471.1 - 2.7e-13 49.8 31.3 2.9e-12 46.4 31.1 2.2 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 EFO62471.1 - 3.7e-06 27.0 0.1 0.00097 19.0 0.1 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFO62471.1 - 0.055 12.9 0.0 0.17 11.3 0.0 1.5 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain MDM31_MDM32 PF08118.11 EFO62471.1 - 0.16 10.6 0.0 0.26 9.9 0.0 1.2 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins DUF3533 PF12051.8 EFO62471.1 - 0.22 10.4 7.3 0.5 9.2 7.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) SHIPPO-rpt PF07004.12 EFO62472.1 - 3.1e-40 135.2 62.4 0.00014 22.6 0.3 12.2 12 0 0 12 12 12 11 Sperm-tail PG-rich repeat ECR1_N PF14382.6 EFO62472.1 - 0.013 15.3 12.2 15 5.5 0.0 7.3 8 0 0 8 8 8 0 Exosome complex exonuclease RRP4 N-terminal region EF-hand_1 PF00036.32 EFO62473.1 - 3.6e-29 98.1 15.3 6.3e-09 34.8 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EFO62473.1 - 1.3e-24 86.5 13.3 1.1e-12 48.2 3.3 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFO62473.1 - 4.4e-24 82.3 11.7 2e-08 33.5 0.2 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EFO62473.1 - 2.7e-19 68.7 10.5 1e-08 34.9 0.5 3.6 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.6 EFO62473.1 - 2.2e-12 47.1 0.4 3.6e-05 24.0 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EFO62473.1 - 6.9e-11 41.1 19.5 1.3e-05 24.5 0.2 5.0 4 1 1 5 5 5 3 EF hand EF-hand_4 PF12763.7 EFO62473.1 - 1.3e-05 25.0 4.9 0.0017 18.3 0.1 2.6 1 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand ERAP1_C PF11838.8 EFO62473.1 - 0.0048 16.5 0.1 0.0061 16.1 0.1 1.1 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Caleosin PF05042.13 EFO62473.1 - 0.016 15.1 4.6 3 7.7 0.0 3.4 1 1 3 4 4 4 0 Caleosin related protein EF-hand_11 PF08976.11 EFO62473.1 - 0.018 15.9 1.6 3.4 8.6 0.2 2.1 1 1 1 2 2 2 0 EF-hand domain SUB1_ProdP9 PF18213.1 EFO62473.1 - 0.033 14.0 0.3 0.056 13.3 0.3 1.5 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 SurA_N_2 PF13623.6 EFO62473.1 - 0.036 13.9 1.4 5.9 6.7 0.2 2.5 1 1 1 2 2 2 0 SurA N-terminal domain GPHH PF16905.5 EFO62473.1 - 0.18 11.6 0.0 5.2 6.9 0.0 2.9 3 0 0 3 3 3 0 Voltage-dependent L-type calcium channel, IQ-associated MgtE_N PF03448.17 EFO62473.1 - 1.6 9.4 6.1 2.1 9.0 1.1 2.8 1 1 1 2 2 2 0 MgtE intracellular N domain Kelch_3 PF13415.6 EFO62474.1 - 3.4e-31 106.9 3.8 6.5e-07 29.5 0.0 6.8 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.6 EFO62474.1 - 1.5e-30 105.0 2.7 1.7e-05 24.7 0.0 6.6 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 EFO62474.1 - 5.2e-26 90.1 1.6 2.7e-07 30.4 0.1 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 EFO62474.1 - 1.5e-18 66.1 11.2 2.6e-07 30.1 0.0 6.3 7 0 0 7 7 7 4 Kelch motif Kelch_6 PF13964.6 EFO62474.1 - 5.2e-18 64.6 7.1 6e-05 23.2 0.1 6.0 5 1 1 6 6 6 3 Kelch motif Kelch_2 PF07646.15 EFO62474.1 - 5.3e-13 48.4 6.5 0.00014 21.7 0.0 5.3 6 0 0 6 6 6 3 Kelch motif WD40 PF00400.32 EFO62474.1 - 6e-06 26.9 8.3 0.097 13.6 0.1 5.5 5 0 0 5 5 5 2 WD domain, G-beta repeat SlyX PF04102.12 EFO62474.1 - 0.019 15.6 0.4 0.019 15.6 0.4 5.8 6 0 0 6 6 6 0 SlyX XH PF03469.14 EFO62474.1 - 0.046 13.6 0.6 0.57 10.1 0.1 2.9 2 1 1 3 3 3 0 XH domain COG5 PF10392.9 EFO62474.1 - 0.71 10.0 7.9 1.5 9.0 1.9 3.8 3 0 0 3 3 3 0 Golgi transport complex subunit 5 Nbl1_Borealin_N PF10444.9 EFO62474.1 - 1 9.0 4.3 35 4.1 0.0 3.7 3 0 0 3 3 3 0 Nbl1 / Borealin N terminal V-SNARE PF05008.15 EFO62474.1 - 1.7 9.1 11.9 2.9 8.3 0.3 4.5 3 0 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus Syntaxin_2 PF14523.6 EFO62474.1 - 1.9 8.9 26.2 9.7 6.6 0.0 5.9 4 3 1 5 5 5 0 Syntaxin-like protein TRAF_BIRC3_bd PF16673.5 EFO62474.1 - 2.4 8.0 7.1 9.7 6.1 0.2 3.9 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain Ribosomal_S19e PF01090.19 EFO62475.1 - 2.9e-37 127.4 0.0 3.1e-37 127.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Ribosomal_L44 PF00935.19 EFO62476.1 - 6.9e-30 103.3 12.0 9.4e-30 102.9 12.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 Ribosomal_L33 PF00471.20 EFO62476.1 - 8 7.0 12.1 0.94 10.0 0.3 2.8 3 0 0 3 3 3 0 Ribosomal protein L33 DnaJ_C PF01556.18 EFO62477.1 - 3.3e-29 101.9 0.0 4.6e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFO62477.1 - 3e-23 81.7 0.6 5.5e-23 80.9 0.6 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EFO62477.1 - 1.5e-14 54.0 16.7 1.9e-14 53.8 15.2 2.0 2 0 0 2 2 2 1 DnaJ central domain Anti-TRAP PF15777.5 EFO62477.1 - 1e-08 35.0 13.5 7.3e-05 22.6 2.5 2.6 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EFO62477.1 - 0.0026 17.7 10.1 0.088 12.8 1.3 2.5 1 1 1 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3797 PF12677.7 EFO62477.1 - 0.029 14.3 1.1 4.3 7.3 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) Zn_Tnp_IS1595 PF12760.7 EFO62477.1 - 0.066 13.2 7.9 1.9 8.5 0.2 3.4 3 0 0 3 3 3 0 Transposase zinc-ribbon domain Lar_restr_allev PF14354.6 EFO62477.1 - 0.11 12.9 9.4 0.67 10.4 1.4 2.9 2 1 1 3 3 3 0 Restriction alleviation protein Lar HHH PF00633.23 EFO62477.1 - 0.17 11.8 0.0 0.43 10.5 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Cys_rich_KTR PF14205.6 EFO62477.1 - 0.33 10.8 2.0 3.3 7.6 0.8 2.5 1 1 1 2 2 2 0 Cysteine-rich KTR TackOD1 PF18551.1 EFO62477.1 - 0.66 9.6 8.1 4 7.1 8.1 2.2 1 1 0 1 1 1 0 Thaumarchaeal output domain 1 TF_Zn_Ribbon PF08271.12 EFO62477.1 - 4.2 7.0 8.5 6.9 6.3 0.1 3.4 2 1 0 2 2 2 0 TFIIB zinc-binding zf-TFIIB PF13453.6 EFO62477.1 - 5 6.5 10.3 12 5.3 0.1 3.8 4 0 0 4 4 4 0 Transcription factor zinc-finger DUF1451 PF07295.11 EFO62477.1 - 6.2 6.9 6.4 17 5.4 0.7 2.4 2 0 0 2 2 2 0 Zinc-ribbon containing domain zf-C3HC4_3 PF13920.6 EFO62478.1 - 7e-09 35.4 49.5 7.6e-06 25.7 9.6 3.6 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFO62478.1 - 1.3e-06 28.1 8.3 1.3e-06 28.1 8.3 3.7 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFO62478.1 - 2.6e-05 24.2 7.3 2.6e-05 24.2 7.3 4.2 3 2 1 4 4 4 2 RING-type zinc-finger zf-RING_5 PF14634.6 EFO62478.1 - 9.4e-05 22.3 10.0 9.4e-05 22.3 10.0 3.8 3 0 0 3 3 3 2 zinc-RING finger domain zf-RING_2 PF13639.6 EFO62478.1 - 0.00018 21.8 8.0 0.00018 21.8 8.0 4.2 3 1 0 3 3 3 2 Ring finger domain zf-C3HC4 PF00097.25 EFO62478.1 - 0.00049 19.9 8.0 0.00049 19.9 8.0 3.7 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFO62478.1 - 0.00058 20.0 10.8 0.00058 20.0 10.8 4.0 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING RRM_3 PF08777.11 EFO62480.1 - 1.7e-14 53.7 0.0 7e-14 51.7 0.0 2.0 2 0 0 2 2 2 1 RNA binding motif La PF05383.17 EFO62480.1 - 4.2e-10 39.5 0.1 8.5e-10 38.5 0.1 1.5 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EFO62480.1 - 8.9e-05 22.2 0.0 0.1 12.4 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ank_2 PF12796.7 EFO62481.1 - 5e-16 59.1 0.1 2.2e-10 41.0 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62481.1 - 3.4e-12 46.4 1.1 0.00024 21.3 0.1 3.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO62481.1 - 3.4e-09 36.7 0.3 0.006 17.0 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 EFO62481.1 - 1.3e-08 34.4 2.2 0.09 13.4 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EFO62481.1 - 6.8e-06 26.5 1.0 0.062 13.9 0.2 3.2 1 1 1 3 3 3 3 Ankyrin repeats (many copies) RanGAP1_C PF07834.11 EFO62482.1 - 0.022 14.4 0.0 0.022 14.4 0.0 1.0 1 0 0 1 1 1 0 RanGAP1 C-terminal domain Protocadherin PF08374.11 EFO62483.1 - 0.00011 22.2 0.8 0.00016 21.7 0.8 1.2 1 0 0 1 1 1 1 Protocadherin TMEM154 PF15102.6 EFO62483.1 - 0.00015 21.7 3.6 0.00015 21.7 3.6 2.3 1 1 2 3 3 3 1 TMEM154 protein family Orf78 PF06024.12 EFO62483.1 - 0.00021 21.5 1.1 0.00047 20.4 1.1 1.5 1 0 0 1 1 1 1 Orf78 (ac78) RIFIN PF02009.16 EFO62483.1 - 0.00023 21.2 1.7 0.00028 20.9 1.4 1.3 1 1 0 1 1 1 1 Rifin Herpes_gE PF02480.16 EFO62483.1 - 0.00029 19.7 0.1 0.00053 18.8 0.1 1.3 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E DUF5527 PF17665.1 EFO62483.1 - 0.00073 19.1 0.1 0.0013 18.3 0.1 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5527) Sigma_reg_N PF13800.6 EFO62483.1 - 0.00098 19.4 1.3 0.0032 17.7 1.3 1.8 1 0 0 1 1 1 1 Sigma factor regulator N-terminal Insulin_TMD PF17870.1 EFO62483.1 - 0.002 18.1 7.9 0.0061 16.6 7.9 1.8 1 0 0 1 1 1 1 Insulin receptor trans-membrane segment Syndecan PF01034.20 EFO62483.1 - 0.0042 17.0 0.4 0.0095 15.8 0.4 1.6 1 0 0 1 1 1 1 Syndecan domain Tmemb_9 PF05434.11 EFO62483.1 - 0.005 16.7 0.2 0.011 15.7 0.2 1.5 1 0 0 1 1 1 1 TMEM9 DUF2207 PF09972.9 EFO62483.1 - 0.0059 15.4 0.3 0.014 14.2 0.1 1.4 1 1 0 1 1 1 1 Predicted membrane protein (DUF2207) EphA2_TM PF14575.6 EFO62483.1 - 0.0081 17.0 2.9 0.011 16.6 1.2 2.0 2 1 0 2 2 1 1 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.6 EFO62483.1 - 0.012 15.9 2.2 0.012 15.9 2.2 2.0 1 1 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF5385 PF17359.2 EFO62483.1 - 0.014 15.0 0.6 0.025 14.1 0.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Mid2 PF04478.12 EFO62483.1 - 0.017 14.9 4.2 0.035 13.9 3.2 2.0 2 1 0 2 2 2 0 Mid2 like cell wall stress sensor DUF3827 PF12877.7 EFO62483.1 - 0.018 13.5 5.9 0.027 12.9 5.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3827) DUF4448 PF14610.6 EFO62483.1 - 0.029 14.2 0.1 0.05 13.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) TMEM52 PF14979.6 EFO62483.1 - 0.03 14.3 1.0 0.077 12.9 0.1 1.9 2 0 0 2 2 2 0 Transmembrane 52 Baculo_11_kDa PF06143.11 EFO62483.1 - 0.033 13.8 2.1 0.076 12.6 2.1 1.6 1 0 0 1 1 1 0 Baculovirus 11 kDa family Peptidase_M56 PF05569.11 EFO62483.1 - 0.041 13.1 0.3 0.062 12.5 0.3 1.3 1 0 0 1 1 1 0 BlaR1 peptidase M56 Comm PF15957.5 EFO62483.1 - 0.042 14.2 0.0 0.042 14.2 0.0 2.7 2 1 0 2 2 2 0 Commissureless DUF3139 PF11337.8 EFO62483.1 - 0.053 14.2 2.4 0.059 14.0 0.7 2.1 2 0 0 2 2 1 0 Protein of unknown function (DUF3139) DUF4834 PF16118.5 EFO62483.1 - 0.074 14.0 0.6 0.074 14.0 0.6 2.3 2 1 0 2 2 1 0 Domain of unknown function (DUF4834) Pilin_N PF07790.11 EFO62483.1 - 0.088 13.7 4.7 2.6 9.1 1.5 2.8 2 1 0 2 2 2 0 Archaeal Type IV pilin, N-terminal Glycophorin_A PF01102.18 EFO62483.1 - 0.092 13.0 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 Glycophorin A DUF4245 PF14030.6 EFO62483.1 - 0.1 12.6 1.0 0.17 11.8 0.1 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF4245) ODV-E18 PF10717.9 EFO62483.1 - 0.11 12.3 2.4 0.15 12.0 0.9 2.0 2 0 0 2 2 1 0 Occlusion-derived virus envelope protein ODV-E18 DUF4330 PF14221.6 EFO62483.1 - 0.13 12.4 6.8 0.13 12.5 2.9 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4330) DUF2500 PF10694.9 EFO62483.1 - 0.14 12.6 0.3 0.92 10.0 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2500) Chordopox_A13L PF05961.11 EFO62483.1 - 0.16 12.2 4.3 0.33 11.2 3.2 2.1 1 1 0 1 1 1 0 Chordopoxvirus A13L protein DUF5383 PF17355.2 EFO62483.1 - 0.4 11.1 3.8 0.17 12.2 1.0 1.8 2 0 0 2 2 1 0 Family of unknown function (DUF5383) MAP17 PF15807.5 EFO62483.1 - 0.45 10.8 2.9 0.3 11.3 0.6 1.9 1 1 1 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 RCR PF12273.8 EFO62483.1 - 0.48 11.1 2.4 1.4 9.6 2.4 1.9 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red FtsX PF02687.21 EFO62483.1 - 1.1 9.7 5.6 2.8 8.5 0.2 2.2 2 0 0 2 2 2 0 FtsX-like permease family Vpu PF00558.19 EFO62483.1 - 2.2 8.1 8.3 8.7 6.2 8.3 2.0 1 1 0 1 1 1 0 Vpu protein Phage_holin_6_1 PF09682.10 EFO62483.1 - 2.4 8.6 7.4 0.74 10.3 3.0 2.0 2 0 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) Pkinase PF00069.25 EFO62484.1 - 1.4e-59 201.7 0.5 2e-59 201.1 0.5 1.2 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EFO62484.1 - 8.3e-46 154.5 3.9 4.7e-11 43.1 0.0 5.3 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EFO62484.1 - 8.6e-33 113.7 0.1 1.5e-32 113.0 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_4 PF13637.6 EFO62484.1 - 6.1e-28 96.8 0.9 8.6e-05 23.0 0.0 5.9 5 0 0 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62484.1 - 6.7e-24 81.4 0.5 0.38 11.5 0.0 9.9 10 0 0 10 10 10 6 Ankyrin repeat Ank_5 PF13857.6 EFO62484.1 - 8.4e-21 73.8 4.1 0.01 16.1 0.0 7.7 3 1 6 9 9 9 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO62484.1 - 9.8e-20 70.1 0.2 0.17 12.4 0.0 9.4 9 0 0 9 9 9 4 Ankyrin repeat Kinase-like PF14531.6 EFO62484.1 - 1.7e-05 24.3 0.0 0.00059 19.2 0.0 2.7 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 EFO62484.1 - 0.024 14.6 0.0 0.068 13.1 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFO62484.1 - 0.031 13.2 0.0 0.14 11.1 0.0 2.0 1 1 0 1 1 1 0 Haspin like kinase domain DEAD PF00270.29 EFO62485.1 - 6.1e-43 146.6 0.0 6.1e-42 143.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO62485.1 - 2.1e-31 108.5 0.8 3.9e-31 107.7 0.2 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Thioredoxin_9 PF14595.6 EFO62485.1 - 0.053 13.3 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin ERCC3_RAD25_C PF16203.5 EFO62485.1 - 0.099 11.8 0.0 0.2 10.8 0.0 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase DUF2179 PF10035.9 EFO62486.1 - 0.15 11.8 0.0 0.44 10.3 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2179) Acetyltransf_10 PF13673.7 EFO62487.1 - 1.5e-10 41.1 0.1 1.9e-10 40.8 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFO62487.1 - 1.1e-07 32.0 0.0 1.6e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFO62487.1 - 5.9e-07 29.8 0.1 9e-07 29.2 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFO62487.1 - 1.2e-06 28.4 0.0 1.9e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EFO62487.1 - 0.0032 17.6 0.0 0.007 16.4 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EFO62487.1 - 0.0082 16.1 0.0 0.098 12.7 0.0 2.3 2 0 0 2 2 2 1 ESCO1/2 acetyl-transferase Acetyltransf_CG PF14542.6 EFO62487.1 - 0.057 13.6 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Pkinase PF00069.25 EFO62489.1 - 1e-24 87.4 0.1 1.5e-24 86.8 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EFO62489.1 - 1.5e-22 80.0 6.9 2.4e-10 40.9 0.1 3.5 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EFO62489.1 - 3.5e-15 56.0 0.1 6.3e-15 55.2 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_3 PF13606.6 EFO62489.1 - 1.3e-08 34.4 0.8 0.15 12.7 0.0 6.2 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 EFO62489.1 - 2e-08 34.3 2.0 0.022 15.1 0.0 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO62489.1 - 4.2e-08 33.3 0.7 0.08 13.4 0.0 5.3 6 0 0 6 6 6 2 Ankyrin repeat Ank_4 PF13637.6 EFO62489.1 - 8e-08 32.7 7.9 0.0088 16.6 0.7 5.4 4 2 2 6 6 6 3 Ankyrin repeats (many copies) Cyclin_N PF00134.23 EFO62491.1 - 0.018 14.8 0.6 0.022 14.5 0.6 1.1 1 0 0 1 1 1 0 Cyclin, N-terminal domain zf-C3HC4_3 PF13920.6 EFO62492.1 - 1.1e-11 44.3 49.4 6.4e-05 22.7 11.7 3.4 3 0 0 3 3 3 3 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFO62492.1 - 1.2e-10 41.3 44.9 5.6e-07 29.6 10.0 4.0 3 1 0 3 3 3 3 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EFO62492.1 - 1.5e-08 34.6 48.5 5e-06 26.4 7.6 4.6 4 0 0 4 4 4 3 RING-type zinc-finger zf-C3HC4 PF00097.25 EFO62492.1 - 1e-07 31.7 48.1 2.9e-05 23.8 14.0 3.6 3 0 0 3 3 3 3 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFO62492.1 - 4.9e-07 29.6 51.7 8e-06 25.7 14.3 4.0 3 1 1 4 4 4 2 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFO62492.1 - 3.1e-05 23.7 15.0 3.1e-05 23.7 15.0 3.6 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EFO62492.1 - 0.0049 16.7 33.5 0.54 10.2 7.5 3.6 3 0 0 3 3 3 3 zf-RING of BARD1-type protein zf-RING_2 PF13639.6 EFO62492.1 - 0.3 11.5 52.6 0.038 14.3 15.1 3.8 3 0 0 3 3 3 0 Ring finger domain Siva PF05458.12 EFO62492.1 - 1.1 8.9 12.6 0.19 11.4 2.2 2.5 2 0 0 2 2 2 0 Cd27 binding protein (Siva) UPRTase PF14681.6 EFO62493.1 - 3.1e-69 232.5 0.0 3.7e-69 232.3 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EFO62493.1 - 1.2e-07 31.4 0.1 2.1e-07 30.6 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PCNA_N PF00705.18 EFO62494.1 - 2.5e-26 91.9 0.1 6.1e-26 90.6 0.1 1.6 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EFO62494.1 - 1.5e-13 51.0 0.0 8.6e-13 48.6 0.0 2.2 1 1 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 EFO62494.1 - 0.00021 20.5 0.1 0.067 12.2 0.1 2.3 1 1 1 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 EFO62494.1 - 0.0039 16.7 0.0 0.0047 16.4 0.0 1.3 1 1 0 1 1 1 1 Rad9 DHC_N2 PF08393.13 EFO62495.1 - 1.1e-33 117.0 4.1 5.7e-20 71.8 0.5 3.3 2 0 0 2 2 2 2 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.7 EFO62495.1 - 7e-10 38.4 1.5 4.9e-07 29.0 0.0 3.6 3 0 0 3 3 3 2 Hydrolytic ATP binding site of dynein motor region AAA_7 PF12775.7 EFO62495.1 - 0.00011 21.8 0.7 0.004 16.7 0.1 3.1 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_22 PF13401.6 EFO62495.1 - 0.0014 19.0 0.0 4 7.7 0.0 3.8 3 0 0 3 3 3 1 AAA domain Dynein_heavy PF03028.15 EFO62495.1 - 0.0068 16.5 0.2 0.02 15.0 0.2 1.9 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 EFO62495.1 - 0.0081 16.0 0.3 0.043 13.6 0.0 2.5 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_16 PF13191.6 EFO62495.1 - 0.056 13.8 0.3 0.92 9.9 0.0 3.3 4 0 0 4 4 4 0 AAA ATPase domain WD40 PF00400.32 EFO62496.1 - 0.012 16.4 1.3 0.097 13.6 0.2 3.0 3 0 0 3 3 3 0 WD domain, G-beta repeat Glucokinase PF02685.16 EFO62497.1 - 6.8e-60 202.7 0.0 7.8e-60 202.5 0.0 1.0 1 0 0 1 1 1 1 Glucokinase ROK PF00480.20 EFO62497.1 - 1.8e-07 30.9 0.0 7.2e-06 25.7 0.1 2.7 2 1 0 2 2 2 1 ROK family Metalloenzyme PF01676.18 EFO62499.1 - 2.6e-70 236.6 0.0 3.5e-70 236.2 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.13 EFO62499.1 - 8.4e-55 185.5 0.0 1.2e-54 185.1 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Phosphodiest PF01663.22 EFO62499.1 - 0.00053 19.7 0.0 0.00078 19.1 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase FeS_assembly_P PF01883.19 EFO62502.1 - 2.7e-06 27.5 0.0 4.7e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein Ank_2 PF12796.7 EFO62503.1 - 1.9e-44 150.2 8.1 7.1e-11 42.5 0.1 7.2 5 2 2 7 7 7 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62503.1 - 9.6e-31 105.5 7.7 4.5e-07 30.0 0.1 8.8 5 3 4 9 9 9 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62503.1 - 7e-29 99.8 5.8 9.6e-10 38.8 0.1 7.6 4 2 3 7 7 7 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO62503.1 - 5.3e-19 67.8 6.1 0.00022 21.5 0.0 8.3 9 0 0 9 9 9 4 Ankyrin repeat Ank_3 PF13606.6 EFO62503.1 - 3.9e-16 57.5 14.7 0.03 14.8 0.0 10.2 10 0 0 10 10 10 4 Ankyrin repeat Pkinase PF00069.25 EFO62503.1 - 9e-07 28.5 0.0 2.5e-06 27.0 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Brix PF04427.18 EFO62505.1 - 8e-19 68.5 1.0 1.1e-18 68.1 0.1 1.6 2 0 0 2 2 2 1 Brix domain SUI1 PF01253.22 EFO62506.1 - 4.9e-11 43.0 0.0 6.3e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 Img2 PF05046.14 EFO62506.1 - 0.035 14.4 0.1 0.057 13.7 0.1 1.4 1 1 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) Pkinase PF00069.25 EFO62507.1 - 1.2e-57 195.3 0.0 2.2e-57 194.5 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62507.1 - 2.1e-32 112.4 0.0 2.8e-21 76.0 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 EFO62507.1 - 0.00052 19.4 0.1 0.00075 18.9 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF5053 PF16476.5 EFO62507.1 - 0.0022 17.6 0.0 0.0042 16.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5053) RIO1 PF01163.22 EFO62507.1 - 0.0086 15.7 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EFO62507.1 - 0.15 11.9 0.0 1.8 8.4 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Cse1 PF08506.10 EFO62509.1 - 6e-12 45.1 0.3 1.4e-11 43.9 0.3 1.5 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.19 EFO62509.1 - 0.00013 21.8 0.0 0.00058 19.7 0.0 2.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EFO62509.1 - 0.18 11.9 5.9 0.066 13.3 0.8 2.9 3 0 0 3 3 3 0 Exportin 1-like protein Pox_MCEL PF03291.16 EFO62510.1 - 5.1e-56 190.2 0.0 7.8e-56 189.6 0.0 1.3 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 EFO62510.1 - 4.5e-05 24.1 0.0 9.9e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFO62510.1 - 0.039 14.6 0.0 0.11 13.2 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain zf-RING_2 PF13639.6 EFO62512.1 - 0.013 15.8 6.0 0.039 14.3 6.0 1.9 1 0 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.7 EFO62512.1 - 0.026 14.8 4.9 0.08 13.2 4.9 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_6 PF14835.6 EFO62512.1 - 0.026 14.4 3.4 0.082 12.8 3.4 1.8 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3H2C3 PF17122.5 EFO62512.1 - 0.042 13.9 7.2 0.086 12.9 7.2 1.6 1 0 0 1 1 1 0 Zinc-finger zf-C3HC4_2 PF13923.6 EFO62512.1 - 0.17 11.7 11.2 0.017 14.9 6.1 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TPR_12 PF13424.6 EFO62512.1 - 0.22 11.8 0.4 6 7.2 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFO62512.1 - 0.32 10.7 0.0 0.32 10.7 0.0 3.2 4 0 0 4 4 4 0 TPR repeat zf-RING_UBOX PF13445.6 EFO62512.1 - 0.94 9.6 7.5 3.1 7.9 7.5 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_11 PF17123.5 EFO62512.1 - 0.96 9.2 5.3 0.41 10.4 1.8 2.3 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_5 PF14634.6 EFO62512.1 - 3.1 7.8 12.9 0.17 11.9 7.0 2.0 2 0 0 2 2 2 0 zinc-RING finger domain 14-3-3 PF00244.20 EFO62513.1 - 6.2e-97 323.4 1.8 7.1e-97 323.3 1.8 1.0 1 0 0 1 1 1 1 14-3-3 protein UPF0767 PF15990.5 EFO62513.1 - 0.19 11.9 0.5 0.62 10.2 0.2 1.9 2 0 0 2 2 2 0 UPF0767 family Aminotran_5 PF00266.19 EFO62514.1 - 1.2e-28 100.1 0.0 2.1e-19 69.7 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class-V MFS_1 PF07690.16 EFO62515.1 - 1.1e-30 106.8 29.9 5.3e-30 104.5 31.1 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFO62515.1 - 1.3e-08 34.2 32.2 1.8e-06 27.1 12.4 2.7 2 1 1 3 3 3 2 Sugar (and other) transporter AAA PF00004.29 EFO62517.1 - 2.1e-41 141.4 0.0 3.6e-41 140.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFO62517.1 - 9.4e-11 41.4 0.0 2.3e-10 40.1 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EFO62517.1 - 1.5e-06 28.0 0.4 3.5e-06 26.9 0.1 1.8 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 EFO62517.1 - 9.7e-06 26.1 0.0 2.6e-05 24.7 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EFO62517.1 - 0.00019 21.5 0.0 0.00083 19.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EFO62517.1 - 0.00052 20.6 0.0 0.0011 19.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 EFO62517.1 - 0.00059 19.1 0.0 0.0012 18.1 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain DUF815 PF05673.13 EFO62517.1 - 0.0019 17.4 0.0 0.0034 16.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EFO62517.1 - 0.0034 17.1 0.0 0.013 15.2 0.0 2.0 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EFO62517.1 - 0.0039 17.4 0.0 0.0084 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFO62517.1 - 0.0053 17.0 0.0 0.01 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EFO62517.1 - 0.0055 16.0 0.0 0.016 14.5 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin Viral_helicase1 PF01443.18 EFO62517.1 - 0.0063 16.3 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase ATG16 PF08614.11 EFO62517.1 - 0.0063 16.8 0.2 0.011 16.0 0.2 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) AAA_22 PF13401.6 EFO62517.1 - 0.0068 16.7 0.3 0.41 10.9 0.3 2.4 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 EFO62517.1 - 0.011 15.6 0.0 2.4 8.0 0.0 2.3 1 1 1 2 2 2 0 NACHT domain AAA_17 PF13207.6 EFO62517.1 - 0.011 16.1 0.0 0.023 15.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFO62517.1 - 0.029 14.8 0.0 0.062 13.7 0.0 1.6 1 1 0 1 1 1 0 RNA helicase KLRAQ PF10205.9 EFO62517.1 - 0.041 14.1 0.3 0.078 13.2 0.3 1.4 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein AAA_25 PF13481.6 EFO62517.1 - 0.058 13.0 0.2 0.19 11.3 0.1 1.7 1 1 0 2 2 2 0 AAA domain Prot_ATP_OB_N PF17758.1 EFO62517.1 - 0.063 12.9 0.1 0.16 11.6 0.1 1.6 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain SKI PF01202.22 EFO62517.1 - 0.08 13.1 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Shikimate kinase AAA_2 PF07724.14 EFO62517.1 - 0.087 12.9 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_3 PF07726.11 EFO62517.1 - 0.088 12.7 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RILP PF11461.8 EFO62517.1 - 3.4 8.0 6.9 0.17 12.1 0.7 2.0 2 0 0 2 2 1 0 Rab interacting lysosomal protein KOW PF00467.29 EFO62520.1 - 8.7e-05 22.3 2.6 0.0066 16.4 0.2 4.1 3 0 0 3 3 3 1 KOW motif ChuX_HutX PF06228.13 EFO62520.1 - 0.018 14.8 0.1 21 4.9 0.0 3.4 3 0 0 3 3 3 0 Haem utilisation ChuX/HutX BAF250_C PF12031.8 EFO62520.1 - 0.021 14.2 0.0 0.045 13.0 0.0 1.5 1 0 0 1 1 1 0 SWI/SNF-like complex subunit BAF250/Osa HAS-barrel PF09378.10 EFO62520.1 - 1.3 9.3 5.6 9.3 6.5 0.1 3.8 4 1 1 5 5 5 0 HAS barrel domain Clathrin PF00637.20 EFO62521.1 - 1.2e-06 28.5 4.8 0.0051 16.7 0.1 5.2 4 2 2 6 6 6 2 Region in Clathrin and VPS ANAPC4_WD40 PF12894.7 EFO62521.1 - 0.021 15.1 0.0 3.4 8.0 0.0 3.5 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain ANAPC3 PF12895.7 EFO62521.1 - 0.04 14.2 6.0 1.9 8.8 0.4 4.9 4 1 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Coatomer_WDAD PF04053.14 EFO62521.1 - 0.073 12.1 0.1 0.31 10.1 0.1 2.1 1 0 0 1 1 1 0 Coatomer WD associated region TPR_1 PF00515.28 EFO62521.1 - 0.11 12.3 5.7 35 4.4 0.1 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFO62521.1 - 1.8 8.6 7.7 51 3.9 0.0 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFO62521.1 - 2.1 8.6 22.5 2.9 8.2 0.1 8.2 9 1 1 10 10 10 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFO62521.1 - 3.5 8.0 12.1 1.9 8.8 0.1 5.8 7 1 1 8 8 8 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFO62521.1 - 4.5 8.0 5.7 27 5.5 0.1 4.6 6 0 0 6 6 6 0 Tetratricopeptide repeat EF-hand_7 PF13499.6 EFO62523.1 - 0.052 14.0 0.3 1.8 9.0 0.2 2.5 1 1 1 2 2 2 0 EF-hand domain pair AAA_16 PF13191.6 EFO62525.1 - 1.6e-10 41.7 1.1 2.4e-09 37.8 0.3 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFO62525.1 - 7.9e-10 39.1 0.0 1.5e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFO62525.1 - 1.1e-06 29.1 0.0 2.8e-06 27.8 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EFO62525.1 - 0.00017 21.6 0.0 0.00065 19.7 0.0 1.9 2 0 0 2 2 2 1 NACHT domain AAA_19 PF13245.6 EFO62525.1 - 0.00023 21.5 0.1 0.0023 18.3 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EFO62525.1 - 0.00088 19.3 0.0 0.0015 18.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EFO62525.1 - 0.0018 17.7 0.0 0.0029 17.0 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 EFO62525.1 - 0.0035 17.1 0.0 0.0062 16.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain Bac_DnaA PF00308.18 EFO62525.1 - 0.0074 16.2 0.1 0.047 13.5 0.1 2.0 1 1 0 1 1 1 1 Bacterial dnaA protein DUF2075 PF09848.9 EFO62525.1 - 0.017 14.4 0.0 0.023 14.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.22 EFO62525.1 - 0.033 13.4 0.0 0.054 12.7 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain NTPase_1 PF03266.15 EFO62525.1 - 0.049 13.5 0.0 9.7 6.1 0.0 2.3 2 0 0 2 2 2 0 NTPase Zot PF05707.12 EFO62525.1 - 0.087 12.5 0.0 0.27 10.9 0.0 1.7 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) DAP3 PF10236.9 EFO62525.1 - 0.13 11.4 0.1 1 8.4 0.0 2.1 1 1 1 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 PA28_beta PF02252.18 EFO62526.1 - 0.023 14.3 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 Proteasome activator pa28 beta subunit DUF5575 PF17738.1 EFO62526.1 - 0.061 12.3 0.0 0.081 12.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5575) Semenogelin PF05474.11 EFO62528.1 - 0.12 10.9 0.0 0.17 10.4 0.0 1.2 1 0 0 1 1 1 0 Semenogelin YwqJ-deaminase PF14431.6 EFO62529.1 - 0.032 14.4 6.8 1.7 8.8 2.3 2.6 2 0 0 2 2 2 0 YwqJ-like deaminase DUF3584 PF12128.8 EFO62529.1 - 0.39 8.2 26.6 0.59 7.6 26.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) HMMR_N PF15905.5 EFO62529.1 - 2.7 7.4 37.1 0.62 9.5 21.6 2.2 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Jnk-SapK_ap_N PF09744.9 EFO62529.1 - 4.2 7.6 34.2 27 4.9 15.4 2.9 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 MbeD_MobD PF04899.12 EFO62529.1 - 6.7 6.9 18.0 0.65 10.1 0.7 4.0 3 1 1 4 4 4 0 MbeD/MobD like DUF948 PF06103.11 EFO62529.1 - 6.9 7.0 10.0 2.5 8.4 2.0 3.3 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Phage_TAC_2 PF06894.11 EFO62530.1 - 0.073 12.9 0.1 2.2 8.1 0.0 2.5 2 0 0 2 2 2 0 Bacteriophage lambda tail assembly chaperone, TAC, protein G ubiquitin PF00240.23 EFO62531.1 - 1.4e-34 117.7 0.6 1.5e-34 117.6 0.6 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFO62531.1 - 4.8e-20 71.2 0.9 5.3e-20 71.0 0.9 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFO62531.1 - 7.7e-07 29.5 0.2 2.9e-06 27.7 0.2 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EFO62531.1 - 0.00013 21.8 0.1 0.00014 21.7 0.1 1.2 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFO62531.1 - 0.00015 21.9 0.1 0.00035 20.7 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EFO62531.1 - 0.00085 19.3 0.4 0.53 10.4 0.0 2.0 2 0 0 2 2 2 2 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EFO62531.1 - 0.0039 17.5 0.1 0.0042 17.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain DUF2407 PF10302.9 EFO62531.1 - 0.026 15.1 0.1 0.03 14.9 0.1 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EFO62531.1 - 0.079 12.8 0.0 0.092 12.6 0.0 1.1 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain TUG-UBL1 PF11470.8 EFO62531.1 - 0.12 12.6 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 TUG ubiquitin-like domain EGF_2 PF07974.13 EFO62532.1 - 0.0016 18.8 18.1 0.0083 16.5 2.6 7.6 7 2 0 7 7 7 4 EGF-like domain Laminin_EGF PF00053.24 EFO62532.1 - 0.0031 17.6 7.3 0.0031 17.6 7.3 6.5 4 1 2 6 6 6 1 Laminin EGF domain Tmemb_9 PF05434.11 EFO62532.1 - 0.028 14.3 0.3 0.091 12.7 0.3 1.8 1 0 0 1 1 1 0 TMEM9 Ninjurin PF04923.12 EFO62532.1 - 0.038 13.9 0.5 0.065 13.2 0.5 1.3 1 0 0 1 1 1 0 Ninjurin Afaf PF15339.6 EFO62532.1 - 0.11 12.2 0.8 0.17 11.6 0.8 1.2 1 0 0 1 1 1 0 Acrosome formation-associated factor Sigma_reg_N PF13800.6 EFO62532.1 - 0.2 11.9 2.0 0.36 11.1 2.0 1.3 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DUF2207 PF09972.9 EFO62532.1 - 0.21 10.3 0.3 0.28 9.9 0.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Vpu PF00558.19 EFO62532.1 - 0.26 11.1 1.0 0.43 10.4 1.0 1.2 1 0 0 1 1 1 0 Vpu protein BaffR-Tall_bind PF09256.10 EFO62532.1 - 3 7.7 10.8 10 6.0 0.3 4.6 4 0 0 4 4 4 0 BAFF-R, TALL-1 binding Ank_2 PF12796.7 EFO62533.1 - 7.5e-43 145.0 13.2 3.6e-14 53.1 0.5 3.1 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EFO62533.1 - 3.8e-22 77.7 0.5 2.6e-05 24.5 0.0 4.8 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 EFO62533.1 - 5.9e-18 65.0 9.8 7.1e-08 32.9 0.2 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62533.1 - 4.2e-13 48.2 2.1 0.056 14.0 0.1 4.8 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 EFO62533.1 - 2.9e-11 43.4 7.8 0.11 12.8 0.3 5.3 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO62533.1 - 9.3e-11 41.6 0.0 1.7e-10 40.7 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62533.1 - 3e-05 23.4 0.0 4.7e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.32 EFO62534.1 - 3.3e-08 34.0 0.2 0.22 12.5 0.0 5.7 5 0 0 5 5 5 2 WD domain, G-beta repeat TPR_19 PF14559.6 EFO62534.1 - 0.047 14.2 0.7 2 9.0 0.3 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 EFO62534.1 - 0.056 12.5 0.9 0.49 9.4 0.3 2.8 4 0 0 4 4 4 0 Coatomer WD associated region PQQ_2 PF13360.6 EFO62534.1 - 0.17 11.5 0.0 2 8.0 0.0 2.3 2 0 0 2 2 2 0 PQQ-like domain zf-ribbon_3 PF13248.6 EFO62534.1 - 3.1 7.3 6.2 40 3.8 0.4 3.4 3 0 0 3 3 3 0 zinc-ribbon domain Glycogen_syn PF05693.13 EFO62536.1 - 3e-133 445.7 1.9 1.9e-120 403.4 0.1 2.0 2 0 0 2 2 2 2 Glycogen synthase Glycos_transf_1 PF00534.20 EFO62536.1 - 1.9e-07 30.7 0.0 0.016 14.7 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EFO62536.1 - 0.00028 20.9 0.1 0.00083 19.4 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 EFO62536.1 - 0.012 16.1 0.0 2.1 8.8 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EFO62536.1 - 0.11 13.0 0.1 0.24 11.8 0.1 1.5 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain MTS PF05175.14 EFO62537.1 - 0.0002 21.0 0.0 0.00074 19.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 EFO62537.1 - 0.083 12.6 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EFO62538.1 - 3e-11 43.2 0.0 1.9e-10 40.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EFO62538.1 - 3.5e-05 24.4 0.0 7.1e-05 23.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFO62538.1 - 8.3e-05 22.1 0.0 0.00011 21.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EFO62538.1 - 0.00059 19.7 0.0 0.00078 19.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFO62538.1 - 0.0071 17.1 0.0 0.016 15.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EFO62538.1 - 0.13 11.6 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain Cons_hypoth95 PF03602.15 EFO62538.1 - 0.18 11.4 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 GST_N PF02798.20 EFO62539.1 - 0.0035 17.7 0.0 0.016 15.5 0.0 2.1 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFO62539.1 - 0.0065 16.9 0.0 0.015 15.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain FNIP_C PF14638.6 EFO62539.1 - 0.17 11.5 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Folliculin-interacting protein C-terminus PRK PF00485.18 EFO62540.1 - 0.052 13.3 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family OGG_N PF07934.12 EFO62540.1 - 0.13 12.3 0.7 0.37 10.9 0.2 2.0 2 0 0 2 2 2 0 8-oxoguanine DNA glycosylase, N-terminal domain AstE_AspA PF04952.14 EFO62541.1 - 0.00015 20.9 0.0 0.00036 19.7 0.0 1.5 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Peptidase_M14 PF00246.24 EFO62541.1 - 0.0034 17.2 0.0 0.0062 16.4 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase Pepdidase_M14_N PF18027.1 EFO62541.1 - 0.024 15.0 0.0 0.049 14.0 0.0 1.5 1 0 0 1 1 1 0 Cytosolic carboxypeptidase N-terminal domain Lactamase_B_6 PF16661.5 EFO62542.1 - 2.5e-11 43.4 0.0 4.6e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 EFO62542.1 - 2.2e-07 31.1 0.0 8.5e-07 29.2 0.0 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFO62542.1 - 1.4e-05 24.8 0.1 5.9e-05 22.7 0.0 2.0 2 1 0 2 2 2 1 Beta-lactamase superfamily domain RMMBL PF07521.12 EFO62542.1 - 2.7e-05 24.0 0.2 8.6e-05 22.4 0.1 1.9 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain TDH PF03347.13 EFO62542.1 - 0.12 11.9 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Vibrio thermostable direct hemolysin PI3_PI4_kinase PF00454.27 EFO62543.1 - 3.3e-55 187.6 0.3 5.7e-55 186.8 0.3 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 EFO62543.1 - 1.9e-28 99.7 0.3 9.5e-25 87.5 0.0 3.4 3 0 0 3 3 3 2 FAT domain DUF3385 PF11865.8 EFO62543.1 - 1.1e-25 90.4 17.9 6.7e-23 81.4 0.6 7.0 4 3 0 4 4 4 2 Domain of unknown function (DUF3385) FRB_dom PF08771.11 EFO62543.1 - 1.4e-20 73.5 0.8 1.6e-19 70.1 0.1 3.0 3 0 0 3 3 3 1 FKBP12-rapamycin binding domain FATC PF02260.20 EFO62543.1 - 1.8e-14 53.2 0.8 5e-14 51.8 0.8 1.9 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.6 EFO62543.1 - 1.8e-05 25.0 0.2 0.021 15.2 0.0 4.9 5 0 0 5 5 5 1 HEAT repeats HEAT PF02985.22 EFO62543.1 - 4.3e-05 23.4 0.2 3.6 8.1 0.0 5.9 6 0 0 6 6 6 1 HEAT repeat Nipped-B_C PF12830.7 EFO62543.1 - 2.6 7.9 5.6 6.7 6.6 0.3 3.6 4 0 0 4 4 4 0 Sister chromatid cohesion C-terminus Ank_2 PF12796.7 EFO62544.1 - 8.5e-91 298.7 39.4 9e-14 51.8 0.1 9.2 3 3 8 11 11 11 11 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62544.1 - 4.9e-50 166.9 23.4 3.7e-05 23.9 0.0 13.1 5 4 9 14 14 14 11 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62544.1 - 4.2e-43 145.2 20.0 3.9e-07 30.5 0.0 12.9 7 5 8 15 15 15 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62544.1 - 5.9e-37 121.5 19.5 0.0066 16.9 0.0 15.4 16 0 0 16 16 16 10 Ankyrin repeat Ank PF00023.30 EFO62544.1 - 9.2e-35 117.6 22.2 0.00089 19.6 0.0 13.6 13 2 1 14 14 14 9 Ankyrin repeat Pirin PF02678.16 EFO62544.1 - 0.033 14.2 0.3 5.1 7.1 0.0 3.6 3 1 1 4 4 4 0 Pirin Toprim_3 PF13362.6 EFO62544.1 - 0.22 11.9 1.0 14 6.1 0.1 3.7 3 0 0 3 3 3 0 Toprim domain DUF2870 PF11069.8 EFO62545.1 - 0.04 14.3 0.2 0.096 13.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2870) Herpes_capsid PF06112.11 EFO62545.1 - 0.12 12.4 7.5 0.18 11.8 7.5 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Ank_2 PF12796.7 EFO62547.1 - 4e-110 360.6 26.4 1.3e-16 61.0 0.0 7.7 2 2 9 11 11 11 11 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62547.1 - 9e-51 169.3 11.4 3e-05 24.2 0.0 10.7 3 2 8 11 11 11 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62547.1 - 6.9e-50 161.2 6.8 0.00015 21.9 0.0 12.4 13 0 0 13 13 13 10 Ankyrin repeat Ank PF00023.30 EFO62547.1 - 2.5e-44 147.8 9.5 0.00024 21.4 0.0 13.1 13 0 0 13 13 13 10 Ankyrin repeat Ank_4 PF13637.6 EFO62547.1 - 1.9e-43 146.3 10.2 2e-09 37.8 0.0 10.3 8 3 4 12 12 12 11 Ankyrin repeats (many copies) VWA_3_C PF18571.1 EFO62547.1 - 0.45 10.4 2.4 48 3.9 0.1 4.3 5 0 0 5 5 5 0 von Willebrand factor type A C-terminal domain RVT_1 PF00078.27 EFO62549.1 - 1.3e-13 51.0 0.0 2.1e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 EFO62550.1 - 0.084 12.4 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) VSP PF03302.13 EFO62552.1 - 1.7e-39 135.8 191.7 7e-09 35.0 32.8 8.3 1 1 7 8 8 8 8 Giardia variant-specific surface protein DUF4690 PF15756.5 EFO62552.1 - 0.00064 20.3 0.5 0.0016 19.0 0.5 1.6 1 0 0 1 1 1 1 Small Novel Rich in Cartilage VSP PF03302.13 EFO62553.1 - 2.2e-41 142.0 183.0 6.2e-32 110.9 51.7 7.2 2 2 4 6 6 6 6 Giardia variant-specific surface protein Kelch_4 PF13418.6 EFO62553.1 - 5.3 7.1 8.3 3.9 7.6 0.1 3.3 3 0 0 3 3 3 0 Galactose oxidase, central domain Prok-RING_1 PF14446.6 EFO62554.1 - 0.015 15.2 8.4 0.021 14.8 3.6 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Plant_tran PF04827.14 EFO62554.1 - 0.032 13.8 0.1 0.07 12.7 0.1 1.5 1 0 0 1 1 1 0 Plant transposon protein PHD PF00628.29 EFO62554.1 - 0.071 13.0 7.3 0.34 10.8 5.5 2.6 2 0 0 2 2 2 0 PHD-finger DZR PF12773.7 EFO62554.1 - 0.27 11.3 7.5 2.4 8.2 3.4 2.6 2 0 0 2 2 2 0 Double zinc ribbon C1_1 PF00130.22 EFO62554.1 - 0.85 9.5 9.3 0.087 12.7 3.8 2.1 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HAD_2 PF13419.6 EFO62555.1 - 8.3e-34 117.2 0.0 1e-33 116.9 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFO62555.1 - 2.1e-14 54.4 0.0 2.2e-13 51.0 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFO62555.1 - 1.5e-10 41.0 0.0 2.7e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 EFO62555.1 - 3.8e-09 37.2 0.1 8.5e-09 36.1 0.1 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EFO62555.1 - 0.00026 21.1 0.0 0.0021 18.1 0.0 2.2 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Acid_PPase PF12689.7 EFO62555.1 - 0.0019 18.1 0.0 0.39 10.6 0.0 2.2 2 0 0 2 2 2 2 Acid Phosphatase Hydrolase_3 PF08282.12 EFO62555.1 - 0.0079 16.0 0.2 12 5.5 0.2 3.0 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase PNK3P PF08645.11 EFO62555.1 - 0.036 13.8 0.0 4.9 6.8 0.0 3.0 1 1 0 1 1 1 0 Polynucleotide kinase 3 phosphatase Ank_2 PF12796.7 EFO62556.1 - 4e-39 133.1 1.9 1.3e-11 44.9 0.0 3.4 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO62556.1 - 3.2e-13 48.6 0.1 0.29 11.8 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EFO62556.1 - 2.9e-11 43.4 3.2 0.021 15.2 0.0 5.4 1 1 4 5 5 5 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62556.1 - 3.1e-11 43.6 0.5 0.001 19.6 0.0 4.0 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO62556.1 - 3.2e-11 43.2 0.0 0.14 12.6 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat Tropomyosin PF00261.20 EFO62556.1 - 0.0034 16.8 3.3 0.007 15.8 3.3 1.5 1 0 0 1 1 1 1 Tropomyosin CENP-F_leu_zip PF10473.9 EFO62556.1 - 0.22 11.5 3.8 0.34 10.9 2.7 1.9 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 RrnaAD PF00398.20 EFO62557.1 - 3e-58 197.0 0.0 3.9e-58 196.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EFO62557.1 - 2e-10 41.2 0.0 4e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFO62557.1 - 4.2e-07 29.9 0.0 9.5e-07 28.7 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFO62557.1 - 1.4e-06 28.9 0.0 3.2e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFO62557.1 - 2.3e-05 24.3 0.0 3.7e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFO62557.1 - 5.1e-05 23.9 0.0 0.0001 23.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 EFO62557.1 - 0.0022 17.7 0.0 0.0033 17.1 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 DREV PF05219.12 EFO62557.1 - 0.0039 16.3 0.0 0.0063 15.7 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase PCMT PF01135.19 EFO62557.1 - 0.0057 16.4 0.0 0.0086 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EFO62557.1 - 0.0059 16.2 0.0 0.0092 15.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EFO62557.1 - 0.017 15.1 0.0 0.03 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 EFO62557.1 - 0.027 13.9 0.0 0.045 13.2 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase CMAS PF02353.20 EFO62557.1 - 0.044 13.1 0.0 0.063 12.6 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EFO62557.1 - 0.052 12.9 0.0 0.073 12.4 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family tRNA_U5-meth_tr PF05958.11 EFO62557.1 - 0.056 12.4 0.0 0.093 11.7 0.0 1.3 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase PrmA PF06325.13 EFO62557.1 - 0.057 12.8 0.0 0.084 12.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Met_10 PF02475.16 EFO62557.1 - 0.059 13.1 0.0 0.092 12.5 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Pox_E8 PF03394.13 EFO62557.1 - 0.094 12.3 0.0 0.38 10.3 0.0 1.8 1 1 1 2 2 2 0 Poxvirus E8 protein DUF43 PF01861.16 EFO62557.1 - 0.15 11.3 0.0 0.24 10.6 0.0 1.3 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain DnaJ PF00226.31 EFO62558.1 - 4.5e-20 71.5 3.3 1.1e-19 70.4 1.7 2.6 2 0 0 2 2 2 1 DnaJ domain TPR_1 PF00515.28 EFO62558.1 - 0.0044 16.8 10.0 0.0087 15.9 0.8 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFO62558.1 - 0.0064 16.5 12.3 0.031 14.4 1.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFO62558.1 - 0.012 16.3 9.1 0.016 15.8 7.5 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFO62558.1 - 0.012 16.4 5.7 7.9 7.6 0.8 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFO62558.1 - 0.41 10.8 1.7 21 5.4 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFO62558.1 - 0.46 11.0 5.9 9.8 6.8 2.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat EamA PF00892.20 EFO62559.1 - 9.8e-10 38.7 20.2 5.9e-09 36.2 2.9 3.1 2 1 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 EFO62559.1 - 2.5e-08 33.3 4.0 2.5e-08 33.3 4.0 2.1 1 1 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like SLC35F PF06027.12 EFO62559.1 - 2.1e-07 30.8 19.3 1.4e-06 28.1 19.3 1.9 1 1 0 1 1 1 1 Solute carrier family 35 PUNUT PF16913.5 EFO62559.1 - 3.4e-07 29.8 4.8 3.4e-07 29.8 4.8 1.7 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport TPT PF03151.16 EFO62559.1 - 4.7e-07 29.4 5.9 1.1e-06 28.2 5.9 1.7 1 1 0 1 1 1 1 Triose-phosphate Transporter family Ilm1 PF10311.9 EFO62559.1 - 0.03 14.0 2.2 2 8.0 0.1 2.3 2 0 0 2 2 2 0 Increased loss of mitochondrial DNA protein 1 DUF3522 PF12036.8 EFO62559.1 - 0.69 10.2 12.5 0.072 13.4 2.3 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3522) DUF202 PF02656.15 EFO62559.1 - 3.3 8.2 10.3 39 4.8 0.1 3.5 2 2 0 2 2 2 0 Domain of unknown function (DUF202) DUF5367 PF17329.2 EFO62559.1 - 4 7.6 10.8 11 6.2 0.4 3.4 2 1 1 3 3 3 0 Family of unknown function (DUF5367) TrbC PF04956.13 EFO62559.1 - 7.5 6.9 10.8 0.47 10.7 4.0 2.6 2 1 0 2 2 2 0 TrbC/VIRB2 family eIF-5_eIF-2B PF01873.17 EFO62560.1 - 3.7e-28 97.7 0.9 7.5e-28 96.8 0.9 1.5 1 0 0 1 1 1 1 Domain found in IF2B/IF5 zinc_ribbon_6 PF14599.6 EFO62560.1 - 0.0031 17.5 1.9 0.67 10.0 0.5 2.6 2 0 0 2 2 2 2 Zinc-ribbon NAPRTase_N PF17767.1 EFO62561.1 - 2.7e-36 124.7 0.0 4.8e-36 123.9 0.0 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain NAPRTase_C PF17956.1 EFO62561.1 - 4.6e-30 104.3 1.3 7.9e-30 103.5 1.3 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase C-terminal domain NAPRTase PF04095.16 EFO62561.1 - 3.8e-07 30.0 0.0 0.00035 20.3 0.0 2.4 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family Prefoldin PF02996.17 EFO62562.1 - 0.0043 17.0 0.0 0.0055 16.6 0.0 1.2 1 0 0 1 1 1 1 Prefoldin subunit zf-RING_5 PF14634.6 EFO62563.1 - 0.00012 22.0 7.5 0.00012 22.0 7.5 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFO62563.1 - 0.0006 20.1 7.8 0.0006 20.1 7.8 2.0 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 EFO62563.1 - 0.0008 19.5 10.1 0.0008 19.5 10.1 2.3 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EFO62563.1 - 0.00082 19.2 8.2 0.00082 19.2 8.2 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFO62563.1 - 0.0014 18.4 10.7 0.0017 18.2 6.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFO62563.1 - 0.0021 17.9 12.2 0.0094 15.8 12.2 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFO62563.1 - 0.0079 16.2 8.6 0.0079 16.2 8.6 1.9 2 0 0 2 2 2 1 RING-type zinc-finger DisA-linker PF10635.9 EFO62563.1 - 0.034 13.9 0.3 0.054 13.3 0.3 1.3 1 0 0 1 1 1 0 DisA bacterial checkpoint controller linker region Baculo_PEP_C PF04513.12 EFO62563.1 - 0.043 13.9 2.6 0.075 13.1 2.6 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus HBB PF06777.11 EFO62563.1 - 0.11 12.1 0.2 0.25 11.0 0.2 1.6 1 1 0 1 1 1 0 Helical and beta-bridge domain Holin_BhlA PF10960.8 EFO62563.1 - 0.13 12.2 0.2 0.41 10.7 0.1 1.9 2 0 0 2 2 2 0 BhlA holin family CENP-F_leu_zip PF10473.9 EFO62563.1 - 0.15 12.1 3.4 0.22 11.5 3.4 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF948 PF06103.11 EFO62563.1 - 0.43 10.9 3.3 6.3 7.1 0.5 2.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Prok-RING_4 PF14447.6 EFO62563.1 - 1.8 8.5 12.0 0.56 10.1 8.0 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 DUF4912 PF16258.5 EFO62564.1 - 0.13 12.5 0.6 0.34 11.1 0.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4912) Mg_trans_NIPA PF05653.14 EFO62565.1 - 6.1e-33 114.2 17.7 9.7e-33 113.5 17.7 1.3 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EFO62565.1 - 2.4e-06 27.8 1.8 2.4e-06 27.8 1.8 2.7 3 1 0 3 3 3 1 EamA-like transporter family MFS_1_like PF12832.7 EFO62565.1 - 0.056 12.3 6.9 0.096 11.5 6.6 1.6 1 1 0 1 1 1 0 MFS_1 like family DHODB_Fe-S_bind PF10418.9 EFO62565.1 - 0.067 13.0 0.3 0.24 11.2 0.3 2.0 1 0 0 1 1 1 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B HeH PF12949.7 EFO62565.1 - 0.21 11.3 0.0 0.38 10.5 0.0 1.4 1 0 0 1 1 1 0 HeH/LEM domain Thioredoxin PF00085.20 EFO62566.1 - 1.8e-06 27.9 0.0 3.8e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EFO62566.1 - 8.4e-05 22.8 0.4 0.0009 19.5 0.0 2.7 3 0 0 3 3 3 1 Thioredoxin-like AhpC-TSA PF00578.21 EFO62566.1 - 0.00015 21.6 0.1 0.002 18.0 0.0 2.3 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 EFO62566.1 - 0.00033 20.4 0.0 0.0026 17.5 0.0 2.0 2 0 0 2 2 2 1 Redoxin Thioredoxin_6 PF13848.6 EFO62566.1 - 0.0027 17.6 0.1 0.014 15.4 0.0 2.1 1 1 1 2 2 2 1 Thioredoxin-like domain TraF PF13728.6 EFO62566.1 - 0.016 15.1 0.7 0.028 14.2 0.0 1.7 2 0 0 2 2 2 0 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 EFO62566.1 - 0.049 13.8 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like zf-H2C2 PF09337.10 EFO62566.1 - 0.057 13.7 0.6 0.15 12.3 0.0 2.0 3 0 0 3 3 3 0 H2C2 zinc finger T4_deiodinase PF00837.17 EFO62566.1 - 0.1 11.9 0.0 0.27 10.5 0.0 1.7 1 1 1 2 2 2 0 Iodothyronine deiodinase DUF2847 PF11009.8 EFO62566.1 - 0.12 12.3 0.0 0.28 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2847) MFS_1 PF07690.16 EFO62567.1 - 2.1e-29 102.5 39.6 2.1e-29 102.5 39.6 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFO62567.1 - 6.9e-05 21.9 34.7 0.0016 17.4 11.5 3.0 1 1 1 2 2 2 2 Sugar (and other) transporter DUF3336 PF11815.8 EFO62570.1 - 0.14 11.8 3.2 0.16 11.7 0.3 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3336) Vps26 PF03643.15 EFO62572.1 - 1.9e-28 99.3 0.0 2.4e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Cnn_1N PF07989.11 EFO62573.1 - 5.8e-06 26.4 3.5 5.8e-06 26.4 3.5 10.5 4 2 6 10 10 10 1 Centrosomin N-terminal motif 1 E2R135 PF11570.8 EFO62573.1 - 0.0017 18.6 1.6 0.0017 18.6 1.6 5.0 5 2 2 7 7 7 1 Coiled-coil receptor-binding R-domain of colicin E2 KASH_CCD PF14662.6 EFO62573.1 - 0.01 15.7 6.2 0.01 15.7 6.2 7.1 3 2 3 6 6 6 0 Coiled-coil region of CCDC155 or KASH DUF2255 PF10012.9 EFO62573.1 - 0.15 12.2 1.5 2.9 8.1 0.1 2.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2255) Ribosomal_L2_C PF03947.18 EFO62575.1 - 9.7e-47 158.3 1.8 9.7e-47 158.3 1.8 1.5 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EFO62575.1 - 3.7e-15 55.7 0.0 2.3e-14 53.1 0.0 2.3 2 1 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain ubiquitin PF00240.23 EFO62576.1 - 1.2e-05 24.9 0.0 2.2e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family TBK1_ULD PF18396.1 EFO62576.1 - 0.12 12.4 0.0 0.28 11.1 0.0 1.6 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD PF11976.8 EFO62576.1 - 0.2 11.5 0.0 0.39 10.6 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF4485 PF14846.6 EFO62577.1 - 2.5e-19 69.1 0.1 6.2e-19 67.8 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4485) DivIC PF04977.15 EFO62577.1 - 0.0024 17.6 1.1 0.0053 16.5 1.1 1.5 1 0 0 1 1 1 1 Septum formation initiator bZIP_2 PF07716.15 EFO62577.1 - 0.049 13.7 1.2 0.13 12.4 1.2 1.7 1 0 0 1 1 1 0 Basic region leucine zipper CASP_C PF08172.12 EFO62577.1 - 0.052 12.9 0.9 0.12 11.7 0.9 1.5 1 0 0 1 1 1 0 CASP C terminal GIT_CC PF16559.5 EFO62577.1 - 0.11 12.3 0.9 0.27 11.1 0.9 1.6 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Baculo_PEP_C PF04513.12 EFO62577.1 - 0.19 11.8 1.3 0.62 10.1 0.1 2.3 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus VSP PF03302.13 EFO62578.1 - 3.1e-23 82.3 38.3 7.9e-19 67.8 9.2 3.0 1 1 2 3 3 3 3 Giardia variant-specific surface protein DUF543 PF04418.12 EFO62578.1 - 0.04 13.9 0.3 0.069 13.1 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF543) Podoplanin PF05808.11 EFO62578.1 - 0.6 10.2 2.7 0.78 9.8 2.7 1.3 1 1 0 1 1 1 0 Podoplanin MMR_HSR1 PF01926.23 EFO62579.1 - 9.8e-14 51.4 0.1 5.6e-12 45.8 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFO62579.1 - 5.7e-06 25.9 0.2 8e-05 22.2 0.0 2.6 3 0 0 3 3 3 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFO62579.1 - 0.00062 19.7 0.2 0.046 13.6 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase RuvB_N PF05496.12 EFO62579.1 - 0.058 13.1 0.1 0.15 11.8 0.1 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain MeaB PF03308.16 EFO62579.1 - 0.091 11.7 0.7 0.22 10.5 0.1 1.9 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB zf-RING_2 PF13639.6 EFO62580.1 - 2.8e-05 24.3 6.6 2.8e-05 24.3 6.6 4.4 4 0 0 4 4 4 2 Ring finger domain zf-RING_UBOX PF13445.6 EFO62580.1 - 0.0073 16.3 10.2 0.086 12.9 1.0 4.3 3 1 1 4 4 4 2 RING-type zinc-finger PHD PF00628.29 EFO62580.1 - 0.019 14.9 5.4 0.019 14.9 5.4 3.8 5 0 0 5 5 5 0 PHD-finger zf-RING_11 PF17123.5 EFO62580.1 - 0.064 13.0 7.0 1.1 9.0 0.1 3.2 2 0 0 2 2 2 0 RING-like zinc finger Ras PF00071.22 EFO62581.1 - 1.6e-49 167.6 0.0 2e-49 167.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFO62581.1 - 1e-24 87.1 0.0 2.2e-24 86.0 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFO62581.1 - 3.3e-06 26.7 0.0 7e-06 25.6 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFO62581.1 - 0.011 15.3 0.2 0.075 12.6 0.2 2.4 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain DNA_pol_E_B PF04042.16 EFO62581.1 - 0.077 12.3 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B SRPRB PF09439.10 EFO62581.1 - 0.12 11.9 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Ank_2 PF12796.7 EFO62582.1 - 1.2e-28 99.5 8.2 3.3e-13 50.0 0.2 4.1 1 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62582.1 - 3.4e-22 78.2 6.9 8.9e-05 22.7 0.4 5.8 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62582.1 - 9.9e-19 67.5 7.4 7.9e-08 32.7 0.0 4.8 4 1 0 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO62582.1 - 4.7e-17 61.6 10.9 0.00017 21.9 0.0 7.2 7 0 0 7 7 7 4 Ankyrin repeat Ank_3 PF13606.6 EFO62582.1 - 4.2e-13 48.2 6.1 0.02 15.4 0.1 6.4 6 0 0 6 6 6 4 Ankyrin repeat Pkinase PF00069.25 EFO62583.1 - 1.3e-71 241.1 0.0 1.5e-71 240.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62583.1 - 3.6e-33 114.9 0.0 7.6e-33 113.9 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFO62583.1 - 6.5e-06 25.3 2.7 3.9e-05 22.8 2.7 2.0 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EFO62583.1 - 1.4e-05 24.6 0.1 6.8e-05 22.3 0.0 2.1 2 1 1 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 EFO62583.1 - 0.0002 20.3 0.0 0.00057 18.8 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EFO62583.1 - 0.0013 18.2 0.5 0.002 17.5 0.5 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFO62583.1 - 0.022 14.7 0.0 0.17 11.8 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family EF-G-binding_N PF07299.11 EFO62583.1 - 0.12 12.9 1.7 16 6.1 0.3 3.0 2 1 0 2 2 2 0 Elongation factor G-binding protein, N-terminal TPR_MLP1_2 PF07926.12 EFO62584.1 - 0.00033 20.7 3.5 0.00033 20.7 3.5 1.8 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein JIP_LZII PF16471.5 EFO62584.1 - 0.0046 17.1 2.1 0.0046 17.1 2.1 1.8 1 1 1 2 2 2 1 JNK-interacting protein leucine zipper II Blo-t-5 PF11642.8 EFO62584.1 - 0.0085 16.1 3.3 0.013 15.4 3.0 1.5 1 1 0 1 1 1 1 Mite allergen Blo t 5 Prefoldin_2 PF01920.20 EFO62584.1 - 0.013 15.5 8.6 0.017 15.1 2.7 2.1 1 1 1 2 2 2 0 Prefoldin subunit DUF3584 PF12128.8 EFO62584.1 - 0.017 12.7 5.8 0.018 12.6 5.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CENP-F_leu_zip PF10473.9 EFO62584.1 - 0.017 15.1 4.8 0.02 14.9 4.8 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.6 EFO62584.1 - 0.019 13.7 7.4 0.022 13.4 7.4 1.0 1 0 0 1 1 1 0 AAA domain Spc7 PF08317.11 EFO62584.1 - 0.022 13.7 9.3 0.025 13.5 9.3 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein Prefoldin PF02996.17 EFO62584.1 - 0.027 14.4 3.8 0.027 14.4 3.8 1.8 1 1 0 1 1 1 0 Prefoldin subunit SYCE1 PF15233.6 EFO62584.1 - 0.028 14.5 5.2 0.031 14.3 5.2 1.1 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 BST2 PF16716.5 EFO62584.1 - 0.028 15.0 1.9 0.028 15.0 1.9 1.7 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 PI3K_P85_iSH2 PF16454.5 EFO62584.1 - 0.039 13.6 5.9 0.064 12.9 2.9 2.0 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF724 PF05266.14 EFO62584.1 - 0.039 13.8 4.0 0.046 13.5 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF4164 PF13747.6 EFO62584.1 - 0.051 13.8 6.9 0.072 13.4 6.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) ADIP PF11559.8 EFO62584.1 - 0.054 13.6 9.0 0.12 12.5 9.0 1.4 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding OmpH PF03938.14 EFO62584.1 - 0.064 13.6 6.0 0.077 13.3 6.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) KELK PF15796.5 EFO62584.1 - 0.069 13.6 6.1 0.11 13.0 5.9 1.5 1 1 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase zf-C4H2 PF10146.9 EFO62584.1 - 0.084 13.2 3.3 0.11 12.8 3.3 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein APG6_N PF17675.1 EFO62584.1 - 0.088 13.3 9.3 0.11 13.0 9.3 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region rpo132 PF12415.8 EFO62584.1 - 0.092 12.1 0.5 0.28 10.5 0.1 1.9 2 0 0 2 2 2 0 Poxvirus DNA dependent RNA polymerase DUF1664 PF07889.12 EFO62584.1 - 0.097 12.7 1.0 0.13 12.3 0.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Peptidase_S46 PF10459.9 EFO62584.1 - 0.099 11.3 3.5 0.1 11.2 3.5 1.0 1 0 0 1 1 1 0 Peptidase S46 DUF5082 PF16888.5 EFO62584.1 - 0.11 12.7 7.3 0.32 11.3 7.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) FAM76 PF16046.5 EFO62584.1 - 0.11 11.8 5.1 0.12 11.7 5.1 1.0 1 0 0 1 1 1 0 FAM76 protein UPF0242 PF06785.11 EFO62584.1 - 0.14 12.3 5.8 0.15 12.1 5.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Seryl_tRNA_N PF02403.22 EFO62584.1 - 0.14 12.3 5.8 0.082 13.1 3.9 1.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain KxDL PF10241.9 EFO62584.1 - 0.17 12.2 4.3 0.19 12.0 3.6 1.5 1 1 1 2 2 2 0 Uncharacterized conserved protein TMF_DNA_bd PF12329.8 EFO62584.1 - 0.19 11.7 10.7 0.099 12.7 1.8 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding TMPIT PF07851.13 EFO62584.1 - 0.28 10.4 3.5 0.29 10.4 3.5 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF3450 PF11932.8 EFO62584.1 - 0.36 10.1 8.4 0.76 9.0 8.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Atg14 PF10186.9 EFO62584.1 - 0.36 9.9 6.5 0.37 9.8 6.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1366 PF07104.11 EFO62584.1 - 0.41 10.4 4.1 1.1 9.0 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1366) zf-ZPR1 PF03367.13 EFO62584.1 - 0.42 10.4 2.3 2.9 7.7 2.3 1.9 1 1 0 1 1 1 0 ZPR1 zinc-finger domain HAUS6_N PF14661.6 EFO62584.1 - 0.44 10.1 4.2 0.5 9.9 4.2 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus BRE1 PF08647.11 EFO62584.1 - 0.67 10.1 10.0 0.88 9.7 10.0 1.3 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase Swi5 PF07061.11 EFO62584.1 - 2 8.6 9.3 3.9 7.6 4.5 2.2 1 1 1 2 2 2 0 Swi5 ZapB PF06005.12 EFO62584.1 - 2.8 8.4 9.3 93 3.6 8.7 2.2 1 1 0 1 1 1 0 Cell division protein ZapB Proteasome PF00227.26 EFO62585.1 - 1e-40 139.2 0.1 1.4e-40 138.9 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit EF-hand_7 PF13499.6 EFO62586.1 - 0.011 16.2 0.1 0.045 14.2 0.1 2.1 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.6 EFO62586.1 - 0.012 15.5 0.1 0.05 13.5 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.32 EFO62586.1 - 0.054 13.1 0.0 0.14 11.8 0.0 1.8 1 0 0 1 1 1 0 EF hand UQ_con PF00179.26 EFO62587.1 - 1.7e-43 147.6 0.0 2.1e-43 147.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFO62587.1 - 0.0019 17.9 0.0 0.0032 17.2 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EFO62587.1 - 0.036 14.3 0.0 0.058 13.7 0.0 1.5 1 0 0 1 1 1 0 RWD domain WD40 PF00400.32 EFO62588.1 - 1.9e-20 72.8 20.9 0.0011 19.8 0.0 10.2 11 0 0 11 11 11 5 WD domain, G-beta repeat Nup160 PF11715.8 EFO62588.1 - 0.00012 20.9 3.1 0.58 8.7 0.0 4.5 4 1 1 5 5 5 2 Nucleoporin Nup120/160 Utp12 PF04003.12 EFO62588.1 - 0.00033 20.9 1.3 0.00033 20.9 1.3 1.8 2 0 0 2 2 2 1 Dip2/Utp12 Family Ge1_WD40 PF16529.5 EFO62588.1 - 0.0053 15.8 0.5 0.29 10.1 0.0 3.4 4 0 0 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 EFO62588.1 - 0.024 14.9 0.0 3 8.2 0.0 4.5 4 1 1 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_S3Ae PF01015.18 EFO62589.1 - 6.5e-59 198.9 0.1 7.8e-59 198.6 0.1 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Nop53 PF07767.11 EFO62590.1 - 8.7e-15 55.0 7.1 1.3e-14 54.4 7.1 1.2 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) FlgM PF04316.13 EFO62590.1 - 1.8 9.0 5.0 2.6 8.5 0.0 3.2 2 1 0 2 2 2 0 Anti-sigma-28 factor, FlgM DUF789 PF05623.12 EFO62591.1 - 4.3e-15 56.2 0.5 1.1e-06 28.6 0.2 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF789) DUF1600 PF07667.11 EFO62591.1 - 0.1 12.8 0.1 0.24 11.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1600) NRDE-2 PF08424.10 EFO62592.1 - 0.0006 19.0 0.1 0.071 12.2 0.0 2.3 2 0 0 2 2 2 2 NRDE-2, necessary for RNA interference EBV-NA3 PF05009.12 EFO62592.1 - 0.012 15.1 0.9 0.02 14.4 0.9 1.3 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) TPR_19 PF14559.6 EFO62592.1 - 0.095 13.2 0.1 0.3 11.6 0.1 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Lebercilin PF15619.6 EFO62593.1 - 0.00084 19.1 5.0 0.00084 19.1 5.0 2.3 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease THDPS_M PF14789.6 EFO62593.1 - 0.016 15.3 0.0 0.071 13.2 0.0 2.1 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase middle Hemerythrin PF01814.23 EFO62593.1 - 0.039 14.6 5.0 0.2 12.3 0.4 2.7 2 1 0 2 2 2 0 Hemerythrin HHE cation binding domain DUF5631 PF18645.1 EFO62593.1 - 0.076 13.4 2.2 0.51 10.7 0.2 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5631) MIS13 PF08202.11 EFO62593.1 - 0.18 11.1 7.3 0.35 10.1 3.5 2.0 2 0 0 2 2 2 0 Mis12-Mtw1 protein family RRT14 PF17075.5 EFO62593.1 - 0.39 10.8 6.6 0.07 13.2 1.7 1.9 2 0 0 2 2 2 0 Regular of rDNA transcription protein 14 YabA PF06156.13 EFO62593.1 - 0.78 10.4 14.1 15 6.3 2.0 3.4 2 2 1 3 3 3 0 Initiation control protein YabA TPR_MLP1_2 PF07926.12 EFO62593.1 - 0.79 9.8 16.7 1 9.4 6.3 2.7 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Allexi_40kDa PF05549.11 EFO62593.1 - 1.2 8.6 4.6 8.1 5.9 1.2 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein Spc7 PF08317.11 EFO62593.1 - 1.5 7.6 14.8 0.63 8.9 1.3 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF724 PF05266.14 EFO62593.1 - 2.5 7.9 13.9 4.9 6.9 5.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) APG6_N PF17675.1 EFO62593.1 - 2.6 8.6 17.1 4.2 7.9 0.9 3.1 2 1 0 2 2 2 0 Apg6 coiled-coil region Mei5 PF10376.9 EFO62593.1 - 3.3 7.5 9.9 0.2 11.5 0.4 2.4 2 1 0 2 2 2 0 Double-strand recombination repair protein zf-CpG_bind_C PF12269.8 EFO62593.1 - 5 6.8 7.7 7.6 6.2 1.3 2.3 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain TEX13 PF15186.6 EFO62593.1 - 5 6.8 9.6 0.76 9.4 4.2 2.2 2 0 0 2 2 2 0 Testis-expressed sequence 13 protein family Tup_N PF08581.10 EFO62593.1 - 5.8 7.3 9.6 7.6 6.9 0.8 2.8 3 0 0 3 3 3 0 Tup N-terminal DUF2203 PF09969.9 EFO62593.1 - 8.5 7.1 12.3 4 8.2 0.8 2.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Peptidase_M20 PF01546.28 EFO62595.1 - 1.4e-12 47.8 0.0 1.8e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFO62595.1 - 9.5e-06 25.5 0.0 2.9e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M42 PF05343.14 EFO62595.1 - 0.001 18.1 0.0 0.065 12.2 0.0 2.2 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase Peptidase_M28 PF04389.17 EFO62595.1 - 0.068 12.8 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 zf-C2HC_2 PF13913.6 EFO62597.1 - 5.6e-21 73.9 34.4 7.1e-10 38.6 2.4 4.5 4 0 0 4 4 4 3 zinc-finger of a C2HC-type zf-ribbon_3 PF13248.6 EFO62597.1 - 0.00019 20.7 1.0 0.00019 20.7 1.0 4.5 5 0 0 5 5 5 1 zinc-ribbon domain zf_UBZ PF18439.1 EFO62597.1 - 0.00054 19.5 16.5 2.2 8.0 0.2 5.1 4 1 1 5 5 5 4 Ubiquitin-Binding Zinc Finger DUF2318 PF10080.9 EFO62597.1 - 0.0016 18.5 17.5 0.41 10.8 0.2 4.5 5 0 0 5 5 5 3 Predicted membrane protein (DUF2318) DZR PF12773.7 EFO62597.1 - 0.0022 18.0 1.4 0.0022 18.0 1.4 4.8 4 1 0 4 4 4 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 EFO62597.1 - 0.012 15.4 4.9 0.012 15.4 4.9 5.7 5 1 1 6 6 6 0 zinc-ribbon domain TRAF6_Z2 PF18048.1 EFO62597.1 - 0.069 13.3 3.8 0.52 10.4 0.3 3.2 3 0 0 3 3 3 0 TNF receptor-associated factor 6 zinc finger 2 zf-C2H2_11 PF16622.5 EFO62597.1 - 0.46 10.3 17.1 3.1 7.7 0.0 5.1 4 1 1 5 5 5 0 zinc-finger C2H2-type HypA PF01155.19 EFO62597.1 - 0.48 10.5 20.3 6.3 6.9 2.2 4.6 4 1 1 5 5 5 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FYVE PF01363.21 EFO62597.1 - 1.8 8.8 20.9 14 5.9 0.0 5.0 5 0 0 5 5 5 0 FYVE zinc finger DUF951 PF06107.11 EFO62597.1 - 4.2 7.4 10.4 0.64 10.0 0.2 3.2 3 0 0 3 3 2 0 Bacterial protein of unknown function (DUF951) zf-dskA_traR PF01258.17 EFO62597.1 - 7 6.7 16.5 44 4.1 0.4 4.5 3 1 1 4 4 4 0 Prokaryotic dksA/traR C4-type zinc finger Ribosom_S12_S23 PF00164.25 EFO62598.1 - 7.6e-43 144.7 0.2 1e-42 144.3 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Peptidase_M6 PF05547.11 EFO62598.1 - 0.01 14.2 0.0 0.012 14.0 0.0 1.0 1 0 0 1 1 1 0 Immune inhibitor A peptidase M6 HTHP PF11534.8 EFO62598.1 - 0.13 12.7 0.0 0.21 12.0 0.0 1.3 1 0 0 1 1 1 0 Hexameric tyrosine-coordinated heme protein (HTHP) TPH PF13868.6 EFO62599.1 - 2e-30 105.5 138.8 2e-30 105.5 138.8 2.2 2 0 0 2 2 2 1 Trichohyalin-plectin-homology domain VSP PF03302.13 EFO62600.1 - 2.2e-70 237.5 140.3 1.9e-27 96.2 60.0 5.1 1 1 3 4 4 4 3 Giardia variant-specific surface protein Nrap PF03813.14 EFO62601.1 - 0.017 15.2 0.1 0.033 14.2 0.1 1.4 1 0 0 1 1 1 0 Nrap protein domain 1 PMC2NT PF08066.12 EFO62603.1 - 0.084 13.6 0.2 21 5.9 0.2 2.9 2 0 0 2 2 2 0 PMC2NT (NUC016) domain DUF3412 PF11892.8 EFO62603.1 - 0.13 12.3 0.0 0.37 10.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3412) GATase_4 PF13230.6 EFO62605.1 - 0.083 11.8 0.0 0.094 11.6 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferases class-II DEAD PF00270.29 EFO62606.1 - 2.8e-34 118.4 0.2 6.9e-34 117.1 0.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO62606.1 - 1.6e-26 92.8 0.2 8.9e-26 90.4 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFO62606.1 - 1.2e-06 28.6 0.1 3e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EFO62606.1 - 4.8e-06 26.1 0.0 9.2e-06 25.2 0.0 1.5 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit AAA_19 PF13245.6 EFO62606.1 - 0.037 14.4 0.0 0.08 13.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 EFO62607.1 - 1.3e-44 152.0 0.0 2.9e-44 150.9 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO62607.1 - 8.8e-31 106.5 0.1 3.4e-30 104.6 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain UTP25 PF06862.12 EFO62607.1 - 0.001 18.0 0.0 0.0056 15.5 0.0 2.1 3 0 0 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 ResIII PF04851.15 EFO62607.1 - 0.044 13.8 0.0 0.094 12.7 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Microtub_bd PF16796.5 EFO62607.1 - 0.058 13.3 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Microtubule binding DSPc PF00782.20 EFO62608.1 - 2.5e-30 105.0 0.1 4.9e-30 104.0 0.1 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFO62608.1 - 0.0016 18.0 0.0 0.0027 17.3 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Actin PF00022.19 EFO62610.1 - 8e-66 222.3 0.0 1.3e-65 221.6 0.0 1.3 1 1 0 1 1 1 1 Actin CsoSCA PF08936.10 EFO62610.1 - 0.086 11.5 0.0 0.14 10.8 0.0 1.2 1 0 0 1 1 1 0 Carboxysome Shell Carbonic Anhydrase MreB_Mbl PF06723.13 EFO62610.1 - 0.1 11.4 0.0 0.46 9.2 0.0 1.8 2 0 0 2 2 2 0 MreB/Mbl protein Ribosomal_L14 PF00238.19 EFO62611.1 - 1.6e-33 115.4 0.1 2.1e-33 115.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e TPR_19 PF14559.6 EFO62612.1 - 1.6e-17 63.8 19.9 0.00017 22.0 0.3 8.0 5 3 3 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.6 EFO62612.1 - 1.1e-16 61.2 8.2 1.5e-05 25.5 0.0 7.2 6 2 0 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFO62612.1 - 4.8e-16 58.8 28.0 4.1e-07 30.1 6.3 6.2 3 2 3 6 6 6 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EFO62612.1 - 4.8e-12 46.0 32.3 0.00019 21.6 1.8 8.3 4 4 2 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 EFO62612.1 - 4.2e-09 35.8 37.5 0.0014 18.6 0.1 9.8 11 0 0 11 11 9 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFO62612.1 - 7e-08 32.1 20.2 1.5 9.2 1.5 7.6 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFO62612.1 - 2e-07 30.5 28.8 0.0038 17.0 0.1 7.8 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFO62612.1 - 5.4e-07 29.9 21.2 1.1 10.2 0.1 7.6 7 2 1 8 8 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFO62612.1 - 5.8e-07 29.7 27.3 0.087 13.5 0.0 9.1 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_9 PF13371.6 EFO62612.1 - 1e-06 28.8 2.5 0.00013 22.0 0.2 3.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFO62612.1 - 6.8e-06 25.7 7.6 0.00071 19.2 0.0 5.3 5 0 0 5 5 5 1 TPR repeat TPR_7 PF13176.6 EFO62612.1 - 8.3e-06 25.5 11.9 0.11 12.5 0.1 6.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFO62612.1 - 8.7e-06 25.4 13.7 0.45 10.5 0.0 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_4 PF07721.14 EFO62612.1 - 1.1e-05 25.6 7.0 3.7 8.5 0.2 6.2 5 0 0 5 5 5 2 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EFO62612.1 - 0.0001 21.9 5.5 0.86 9.3 0.0 5.3 4 2 2 6 6 6 1 Bacterial type III secretion protein (HrpB1_HrpK) PPR_2 PF13041.6 EFO62612.1 - 0.00019 21.5 0.0 38 4.6 0.0 4.9 4 0 0 4 4 4 0 PPR repeat family DUF5588 PF17826.1 EFO62612.1 - 0.024 13.6 0.0 0.058 12.3 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5588) PPR PF01535.20 EFO62612.1 - 0.055 13.7 11.2 62 4.2 0.0 6.3 7 0 0 7 7 6 0 PPR repeat Fis1_TPR_C PF14853.6 EFO62612.1 - 0.3 11.2 7.5 15 5.7 0.3 4.7 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat EGF PF00008.27 EFO62613.1 - 0.0079 16.5 4.6 0.0079 16.5 4.6 12.0 10 3 1 11 11 11 3 EGF-like domain Ephrin_rec_like PF07699.13 EFO62614.1 - 0.074 12.8 34.4 0.14 11.9 1.5 7.3 6 1 1 7 7 7 0 Putative ephrin-receptor like Reprolysin_3 PF13582.6 EFO62614.1 - 1.7 9.2 4.4 1.1 9.7 0.8 2.3 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Lustrin_cystein PF14625.6 EFO62614.1 - 3.4 8.1 21.1 6.1 7.3 4.3 5.0 3 2 1 4 4 4 0 Lustrin, cysteine-rich repeated domain EGF_2 PF07974.13 EFO62615.1 - 3.8e-20 72.0 151.4 0.0017 18.7 7.0 14.3 12 3 2 14 14 14 11 EGF-like domain EGF PF00008.27 EFO62615.1 - 2.4e-05 24.5 25.5 0.00052 20.3 2.7 15.1 14 2 1 15 15 15 6 EGF-like domain FXa_inhibition PF14670.6 EFO62615.1 - 0.0054 17.0 4.4 0.0054 17.0 4.4 13.1 6 3 5 11 11 11 3 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 EFO62615.1 - 0.0089 16.2 7.6 0.0089 16.2 7.6 12.8 7 5 3 10 10 10 3 Calcium-binding EGF domain hEGF PF12661.7 EFO62615.1 - 0.013 16.1 3.5 0.013 16.1 3.5 16.4 18 3 1 19 19 19 0 Human growth factor-like EGF VSP PF03302.13 EFO62616.1 - 2.6e-15 56.2 45.6 4.9e-14 52.0 32.8 7.4 2 1 5 7 7 7 3 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO62616.1 - 1.2e-06 28.6 19.8 1.2e-06 28.6 19.8 11.8 3 2 9 12 12 12 6 Furin-like repeat, cysteine-rich TMEM132D_C PF15706.5 EFO62616.1 - 0.0044 16.7 0.0 0.037 13.8 0.0 2.2 2 0 0 2 2 2 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term YebO PF13974.6 EFO62616.1 - 0.2 11.8 0.5 0.35 11.0 0.5 1.4 1 0 0 1 1 1 0 YebO-like protein FOP_dimer PF09398.10 EFO62617.1 - 3.3e-08 33.7 0.0 5.4e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 FOP N terminal dimerisation domain Ank_2 PF12796.7 EFO62618.1 - 2.7e-33 114.4 7.5 4.4e-09 36.8 0.6 5.8 4 2 2 6 6 6 4 Ankyrin repeats (3 copies) Ank PF00023.30 EFO62618.1 - 2.8e-18 65.5 4.8 0.0036 17.7 0.0 8.1 7 1 1 8 8 8 4 Ankyrin repeat Ank_4 PF13637.6 EFO62618.1 - 3.7e-18 65.6 2.4 0.0041 17.7 0.0 6.1 5 1 0 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62618.1 - 3e-17 62.5 4.3 0.029 14.7 0.0 7.0 4 2 3 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62618.1 - 1.3e-16 59.0 5.9 0.011 16.2 0.0 7.8 8 0 0 8 8 8 4 Ankyrin repeat DUF3584 PF12128.8 EFO62618.1 - 0.081 10.4 26.8 0.019 12.5 15.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DUF5340 PF17275.2 EFO62618.1 - 0.15 12.2 6.9 0.21 11.7 0.9 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5340) Golgin_A5 PF09787.9 EFO62618.1 - 0.55 9.7 40.9 0.34 10.3 1.9 3.4 2 1 1 3 3 3 0 Golgin subfamily A member 5 RILP PF11461.8 EFO62618.1 - 1.6 9.0 12.6 2 8.7 0.7 4.5 4 0 0 4 4 4 0 Rab interacting lysosomal protein Peptidase_A3 PF02160.15 EFO62618.1 - 2.6 7.5 4.7 12 5.3 0.4 2.6 2 0 0 2 2 2 0 Cauliflower mosaic virus peptidase (A3) FliD_N PF02465.18 EFO62618.1 - 5.5 7.8 16.8 0.76 10.5 2.6 4.3 3 1 1 4 4 3 0 Flagellar hook-associated protein 2 N-terminus RSS_P20 PF11757.8 EFO62618.1 - 6.7 7.2 9.3 6.4 7.3 1.0 3.2 3 0 0 3 3 3 0 Suppressor of RNA silencing P21-like N-terminal domain DUF349 PF03993.12 EFO62618.1 - 8.3 6.8 9.1 18 5.7 2.0 3.6 2 1 1 3 3 3 0 Domain of Unknown Function (DUF349) Apq12 PF12716.7 EFO62619.1 - 2 8.4 9.0 0.31 11.0 2.2 2.5 3 0 0 3 3 3 0 Nuclear pore assembly and biogenesis Beta_helix PF13229.6 EFO62621.1 - 4.5e-08 33.1 5.0 0.0045 16.8 1.1 3.2 3 0 0 3 3 3 2 Right handed beta helix region NosD PF05048.13 EFO62621.1 - 7.7e-05 22.1 0.4 0.18 11.0 0.0 3.3 2 1 1 3 3 3 2 Periplasmic copper-binding protein (NosD) Adeno_E1B_55K PF01696.17 EFO62621.1 - 0.1 11.2 6.8 0.097 11.3 3.6 2.4 2 0 0 2 2 2 0 Adenovirus EB1 55K protein / large t-antigen Ank_2 PF12796.7 EFO62623.1 - 3.9e-12 46.6 0.0 1.5e-11 44.8 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62623.1 - 1.3e-07 32.0 0.1 0.00011 22.7 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62623.1 - 7.2e-05 22.9 0.0 0.04 14.4 0.0 3.7 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 EFO62623.1 - 0.0025 18.2 0.0 0.15 12.6 0.0 3.7 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EFO62623.1 - 0.0058 16.9 0.1 0.081 13.3 0.0 2.9 1 1 2 3 3 3 1 Ankyrin repeats (many copies) Lipoprotein_7 PF01540.16 EFO62623.1 - 0.078 12.3 2.2 0.22 10.8 0.6 2.3 2 0 0 2 2 2 0 Adhesin lipoprotein Goodbye PF17109.5 EFO62623.1 - 0.49 10.9 6.9 3.2 8.2 0.3 4.1 4 0 0 4 4 4 0 fungal STAND N-terminal Goodbye domain Vir_act_alpha_C PF10400.9 EFO62623.1 - 0.58 10.9 10.0 2.2 9.0 0.0 4.5 5 1 0 5 5 5 0 Virulence activator alpha C-term Spidroin_N PF16763.5 EFO62623.1 - 0.63 10.1 0.0 0.63 10.1 0.0 2.8 3 0 0 3 3 3 0 Major ampullate spidroin 1, spider silk protein 1, N-term Kinesin_assoc PF16183.5 EFO62623.1 - 1.4 9.1 9.0 9.1 6.4 0.1 4.5 4 2 0 5 5 5 0 Kinesin-associated Ank_2 PF12796.7 EFO62624.1 - 0.00044 20.8 0.8 0.0051 17.4 0.0 2.5 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) SlyX PF04102.12 EFO62624.1 - 0.73 10.5 6.2 12 6.5 0.7 3.6 2 1 1 3 3 3 0 SlyX Cnn_1N PF07989.11 EFO62624.1 - 1.1 9.5 7.1 1 9.5 1.0 2.7 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 CLZ PF16526.5 EFO62624.1 - 1.6 9.1 7.0 0.65 10.4 1.5 2.8 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Fib_alpha PF08702.10 EFO62624.1 - 1.9 8.6 7.6 1.5 9.0 5.1 2.1 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Ank_2 PF12796.7 EFO62625.1 - 3.1e-51 171.9 7.6 7.8e-12 45.6 0.1 6.4 3 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62625.1 - 3.4e-31 106.9 4.8 0.0002 21.5 0.0 7.6 5 2 2 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62625.1 - 5.6e-25 84.7 7.3 0.062 13.9 0.0 9.9 10 0 0 10 10 10 6 Ankyrin repeat Ank_4 PF13637.6 EFO62625.1 - 6.4e-23 80.8 8.4 2.6e-07 31.0 0.0 8.2 7 2 3 10 10 10 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO62625.1 - 5e-21 74.2 7.4 0.12 12.9 0.1 9.7 9 1 1 10 10 10 6 Ankyrin repeat PKcGMP_CC PF16808.5 EFO62625.1 - 2.4e-05 24.1 34.9 0.0082 16.0 0.8 7.2 6 0 0 6 6 6 3 Coiled-coil N-terminus of cGMP-dependent protein kinase Mto2_bdg PF12808.7 EFO62625.1 - 8 6.9 16.7 49 4.3 1.3 5.5 4 0 0 4 4 4 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Ank_2 PF12796.7 EFO62626.1 - 1.9e-56 188.6 13.3 1.3e-14 54.5 0.0 6.4 2 2 5 7 7 7 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62626.1 - 1.5e-30 104.9 8.1 2.7e-07 30.7 0.0 8.3 5 3 3 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO62626.1 - 1.5e-29 101.1 6.8 0.00061 20.1 0.1 10.8 10 0 0 10 10 10 7 Ankyrin repeat Ank_3 PF13606.6 EFO62626.1 - 3.1e-27 91.6 4.0 0.096 13.3 0.0 10.9 10 0 0 10 10 10 7 Ankyrin repeat Ank_4 PF13637.6 EFO62626.1 - 2.4e-25 88.6 7.2 1.1e-05 25.9 0.1 7.2 6 2 1 7 7 7 4 Ankyrin repeats (many copies) Spc29 PF17082.5 EFO62626.1 - 0.00051 20.0 5.6 0.00051 20.0 5.6 5.3 2 2 2 4 4 4 2 Spindle Pole Component 29 ZapB PF06005.12 EFO62626.1 - 0.001 19.5 0.8 0.001 19.5 0.8 8.4 4 2 4 8 8 7 1 Cell division protein ZapB betaPIX_CC PF16523.5 EFO62626.1 - 0.0069 16.2 0.3 0.0069 16.2 0.3 4.9 3 2 2 6 6 6 1 betaPIX coiled coil DUF1664 PF07889.12 EFO62626.1 - 0.029 14.4 43.5 0.11 12.5 5.1 5.7 4 1 1 5 5 5 0 Protein of unknown function (DUF1664) DNA_photolyase PF00875.18 EFO62626.1 - 1.3 9.0 7.5 0.34 10.9 0.3 3.2 2 1 0 3 3 3 0 DNA photolyase bZIP_1 PF00170.21 EFO62626.1 - 5.2 7.2 51.6 0.19 11.8 1.5 7.4 6 1 1 7 7 7 0 bZIP transcription factor APG6_N PF17675.1 EFO62626.1 - 8.3 6.9 93.2 0.038 14.5 11.1 5.6 2 2 3 5 5 5 0 Apg6 coiled-coil region Oxidored_FMN PF00724.20 EFO62627.1 - 3.5e-13 49.6 0.0 1.1e-07 31.5 0.0 2.5 2 1 0 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family Ribosomal_S3_C PF00189.20 EFO62627.1 - 0.012 16.1 0.1 0.054 14.0 0.0 2.1 2 0 0 2 2 2 0 Ribosomal protein S3, C-terminal domain NanE PF04131.14 EFO62627.1 - 0.18 11.0 0.0 0.38 9.9 0.0 1.4 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase Ras PF00071.22 EFO62628.1 - 1.2e-08 34.8 0.1 1e-07 31.7 0.1 2.0 1 1 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EFO62628.1 - 0.0019 18.2 0.0 0.0041 17.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EFO62628.1 - 0.011 15.9 0.1 0.037 14.2 0.1 2.0 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFO62628.1 - 0.024 14.1 0.1 1.7 8.1 0.0 2.1 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_18 PF13238.6 EFO62628.1 - 0.11 13.0 0.1 0.28 11.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain VSP PF03302.13 EFO62629.1 - 8.7e-89 298.1 107.5 1.1e-49 169.4 27.6 4.0 1 1 3 4 4 4 4 Giardia variant-specific surface protein VSP PF03302.13 EFO62630.1 - 8.1e-05 21.6 30.9 8.1e-05 21.6 30.9 6.8 1 1 3 5 5 5 2 Giardia variant-specific surface protein Ank_2 PF12796.7 EFO62631.1 - 2.1e-121 396.7 6.7 3.8e-15 56.2 0.0 9.3 1 1 8 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62631.1 - 5e-79 259.7 6.9 4.9e-08 33.4 0.0 12.9 10 2 3 13 13 13 12 Ankyrin repeats (many copies) Ank PF00023.30 EFO62631.1 - 1.4e-68 224.5 11.1 0.00037 20.8 0.0 16.7 16 1 1 17 17 17 15 Ankyrin repeat Ank_5 PF13857.6 EFO62631.1 - 8.2e-66 217.2 21.1 2.1e-06 27.9 0.1 16.4 3 1 14 17 17 17 14 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62631.1 - 7.2e-57 182.7 15.8 0.069 13.7 0.0 17.1 17 0 0 17 17 17 16 Ankyrin repeat Pkinase PF00069.25 EFO62631.1 - 1.6e-20 73.6 0.0 3.3e-20 72.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62631.1 - 1.3e-11 44.3 0.0 2.1e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase VSP PF03302.13 EFO62632.1 - 1.7e-94 316.9 105.0 9.6e-51 172.9 28.9 4.2 1 1 2 4 4 4 3 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO62632.1 - 0.025 14.7 0.4 0.061 13.4 0.4 1.6 1 0 0 1 1 1 0 Podoplanin Annexin PF00191.20 EFO62633.1 - 0.01 15.9 0.0 6.5 6.9 0.1 3.4 3 0 0 3 3 3 0 Annexin Annexin PF00191.20 EFO62634.1 - 7.8e-06 25.9 0.4 0.49 10.5 0.0 4.2 4 0 0 4 4 4 2 Annexin Ribosomal_L4 PF00573.22 EFO62634.1 - 0.072 12.8 0.1 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L4/L1 family Annexin PF00191.20 EFO62635.1 - 1.5e-09 37.8 0.0 6e-05 23.0 0.0 4.1 4 0 0 4 4 4 3 Annexin ASH PF15780.5 EFO62636.1 - 2.4e-10 40.5 3.0 0.0015 18.7 0.0 7.1 7 0 0 7 7 7 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Dzip-like_N PF13815.6 EFO62637.1 - 0.00016 21.6 0.6 0.00016 21.6 0.6 2.0 2 0 0 2 2 2 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal SseB_C PF14581.6 EFO62637.1 - 0.0028 17.7 0.0 0.66 10.1 0.1 2.3 2 0 0 2 2 2 1 SseB protein C-terminal domain Wtap PF17098.5 EFO62637.1 - 0.017 15.0 0.0 0.056 13.4 0.0 1.7 1 1 0 1 1 1 0 WTAP/Mum2p family RICH PF05062.12 EFO62637.1 - 0.02 15.2 1.8 0.047 14.0 0.2 2.1 2 0 0 2 2 2 0 RICH domain zf_C2H2_ZHX PF18387.1 EFO62637.1 - 0.041 13.5 0.2 0.11 12.2 0.2 1.6 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain DASH_Dam1 PF08653.10 EFO62637.1 - 0.051 13.4 0.1 2.2 8.1 0.0 2.4 2 0 0 2 2 2 0 DASH complex subunit Dam1 Snapin_Pallidin PF14712.6 EFO62637.1 - 0.066 13.6 1.1 0.066 13.6 1.1 1.8 2 0 0 2 2 2 0 Snapin/Pallidin DUF1192 PF06698.11 EFO62637.1 - 0.16 12.1 1.2 0.32 11.1 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) FlxA PF14282.6 EFO62637.1 - 0.21 11.6 4.2 0.11 12.5 0.8 2.0 2 0 0 2 2 2 0 FlxA-like protein zf-C2H2 PF00096.26 EFO62637.1 - 0.9 10.1 4.9 0.88 10.2 2.9 2.1 2 0 0 2 2 1 0 Zinc finger, C2H2 type DivIC PF04977.15 EFO62637.1 - 2.3 8.1 5.6 0.51 10.1 0.9 2.0 2 0 0 2 2 2 0 Septum formation initiator Proteasome PF00227.26 EFO62638.1 - 3.5e-49 166.9 0.1 4.5e-49 166.5 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFO62638.1 - 8e-12 44.6 0.0 1.4e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Csm1_N PF18504.1 EFO62639.1 - 0.66 10.3 10.3 1.4 9.3 0.7 3.0 3 0 0 3 3 3 0 Csm1 N-terminal domain DUF4164 PF13747.6 EFO62639.1 - 1.2 9.5 6.0 2.1 8.7 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) TelA PF05816.11 EFO62640.1 - 0.0035 16.4 17.1 0.0051 15.9 17.1 1.2 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) DUF724 PF05266.14 EFO62640.1 - 0.0052 16.6 23.1 0.024 14.5 9.6 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF724) SHE3 PF17078.5 EFO62640.1 - 0.0072 16.1 20.9 0.43 10.3 5.9 2.3 1 1 1 2 2 2 2 SWI5-dependent HO expression protein 3 DivIC PF04977.15 EFO62640.1 - 0.0095 15.7 3.5 0.0095 15.7 3.5 4.2 1 1 2 4 4 4 1 Septum formation initiator ERM PF00769.19 EFO62640.1 - 0.032 14.1 33.6 0.24 11.2 14.9 2.4 1 1 1 2 2 2 0 Ezrin/radixin/moesin family APG6_N PF17675.1 EFO62640.1 - 0.075 13.6 30.0 0.15 12.6 14.5 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region Prp19 PF08606.11 EFO62640.1 - 0.099 12.6 0.5 0.099 12.6 0.5 2.8 2 2 0 2 2 2 0 Prp19/Pso4-like MbeD_MobD PF04899.12 EFO62640.1 - 0.25 11.5 14.7 0.2 11.8 2.9 3.3 2 1 1 3 3 3 0 MbeD/MobD like DUF1664 PF07889.12 EFO62640.1 - 0.34 10.9 17.8 0.7 9.9 3.9 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Leu_zip PF15294.6 EFO62640.1 - 0.38 10.2 23.7 0.14 11.7 15.4 2.1 1 1 1 2 2 2 0 Leucine zipper Jnk-SapK_ap_N PF09744.9 EFO62640.1 - 0.46 10.7 28.4 0.71 10.1 12.9 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF3450 PF11932.8 EFO62640.1 - 0.57 9.4 27.2 0.91 8.8 10.4 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) BRE1 PF08647.11 EFO62640.1 - 0.81 9.8 27.0 0.96 9.6 9.3 2.7 1 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase DUF4472 PF14739.6 EFO62640.1 - 1 10.1 23.5 0.29 11.9 8.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) DUF4201 PF13870.6 EFO62640.1 - 1.5 8.5 28.9 4.1 7.1 3.7 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) WXG100 PF06013.12 EFO62640.1 - 2.5 8.4 12.7 13 6.1 1.7 4.1 1 1 2 3 3 3 0 Proteins of 100 residues with WXG NPV_P10 PF05531.12 EFO62640.1 - 2.5 8.6 12.2 8.8 6.9 4.4 2.9 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein AAA_13 PF13166.6 EFO62640.1 - 2.7 6.5 22.9 3.5 6.2 21.8 1.4 1 1 0 1 1 1 0 AAA domain BLOC1_2 PF10046.9 EFO62640.1 - 2.9 8.3 18.5 4.7 7.6 6.3 3.4 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TPR_MLP1_2 PF07926.12 EFO62640.1 - 2.9 7.9 34.5 0.52 10.4 8.5 2.7 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Mod_r PF07200.13 EFO62640.1 - 3.6 7.7 27.2 7.6 6.6 10.6 2.4 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF4763 PF15960.5 EFO62640.1 - 4.2 6.6 21.5 9.7 5.4 21.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) Spc7 PF08317.11 EFO62640.1 - 4.3 6.1 27.4 7.8 5.3 12.7 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein YabA PF06156.13 EFO62640.1 - 9.6 6.9 20.9 3.7 8.2 5.4 2.7 1 1 0 2 2 2 0 Initiation control protein YabA RRP7 PF12923.7 EFO62641.1 - 6.8e-18 64.9 2.5 8.7e-18 64.6 2.5 1.1 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_1 PF00076.22 EFO62641.1 - 0.021 14.6 0.1 0.061 13.2 0.0 1.8 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TRAF_BIRC3_bd PF16673.5 EFO62641.1 - 0.36 10.6 1.6 0.7 9.7 1.6 1.4 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain JHY PF15261.6 EFO62641.1 - 0.44 11.3 3.3 0.78 10.5 3.3 1.4 1 1 0 1 1 1 0 Jhy protein tRNA-synt_2b PF00587.25 EFO62643.1 - 9.6e-36 123.4 0.0 2.2e-35 122.2 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA_SAD PF07973.14 EFO62643.1 - 3.6e-13 49.4 0.0 7.4e-13 48.4 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain HGTP_anticodon PF03129.20 EFO62643.1 - 8.5e-12 45.1 0.1 1.6e-11 44.1 0.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 EFO62643.1 - 0.041 13.9 0.0 0.09 12.8 0.0 1.6 1 0 0 1 1 1 0 TGS domain Annexin PF00191.20 EFO62644.1 - 2.9e-07 30.5 0.9 0.15 12.2 0.0 3.3 3 0 0 3 3 3 3 Annexin PRO8NT PF08082.11 EFO62645.1 - 0.11 12.4 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 PRO8NT (NUC069), PrP8 N-terminal domain Annexin PF00191.20 EFO62646.1 - 3.2e-13 49.5 0.0 0.0045 17.0 0.0 3.6 4 0 0 4 4 4 3 Annexin YaaC PF14175.6 EFO62646.1 - 0.17 11.1 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 YaaC-like Protein BST2 PF16716.5 EFO62647.1 - 1.8 9.2 10.6 6.4 7.4 0.1 4.4 3 1 0 4 4 4 0 Bone marrow stromal antigen 2 Rrf2 PF02082.20 EFO62648.1 - 1.8e-05 25.0 0.0 4.4e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Transcriptional regulator Adhesin_P1_N PF18652.1 EFO62648.1 - 0.044 13.8 6.7 1.6 8.8 3.9 3.9 2 1 1 3 3 3 0 Adhesin P1 N-terminal domain Nup54_57_C PF18570.1 EFO62648.1 - 0.05 13.2 2.5 7.9 6.2 0.0 3.5 3 0 0 3 3 3 0 NUP57/Nup54 C-terminal domain DUF948 PF06103.11 EFO62648.1 - 0.23 11.7 6.7 2.1 8.7 1.3 3.9 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) MPS2 PF17060.5 EFO62648.1 - 0.48 9.6 9.4 3 7.0 5.1 2.5 2 0 0 2 2 2 0 Monopolar spindle protein 2 Cytochrom_B562 PF07361.11 EFO62648.1 - 1.1 10.0 9.6 14 6.4 0.1 3.2 2 0 0 2 2 2 0 Cytochrome b562 SKA2 PF16740.5 EFO62648.1 - 1.4 8.7 12.2 0.19 11.5 6.8 2.4 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 DUF3496 PF12001.8 EFO62648.1 - 2 8.8 13.5 0.29 11.5 8.1 2.5 2 0 0 2 2 1 0 Domain of unknown function (DUF3496) TMPIT PF07851.13 EFO62648.1 - 2.7 7.2 10.7 1.2 8.3 7.0 2.2 3 0 0 3 3 3 0 TMPIT-like protein UPF0242 PF06785.11 EFO62648.1 - 3.5 7.7 17.4 0.96 9.5 12.0 2.7 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus V-SNARE PF05008.15 EFO62648.1 - 4.1 7.8 15.5 20 5.6 0.0 3.5 3 1 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus SlyX PF04102.12 EFO62648.1 - 7 7.4 14.2 60 4.4 5.4 4.5 3 1 1 4 4 4 0 SlyX Tup_N PF08581.10 EFO62648.1 - 8.1 6.8 16.2 12 6.3 11.1 3.8 2 1 1 3 3 2 0 Tup N-terminal DUF1664 PF07889.12 EFO62648.1 - 9.5 6.3 11.8 19 5.3 3.0 3.5 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) Ank_2 PF12796.7 EFO62649.1 - 8.6e-22 77.5 3.3 2e-08 34.7 0.0 4.6 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62649.1 - 1.2e-14 54.2 3.3 3.5e-07 30.4 0.1 4.7 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62649.1 - 6.7e-12 44.5 0.8 0.39 11.4 0.0 7.2 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.30 EFO62649.1 - 6.3e-06 26.4 3.2 1.2 9.7 0.0 5.1 5 1 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.6 EFO62649.1 - 9.3e-06 26.1 2.4 0.0065 17.0 0.1 4.9 6 2 2 8 8 7 2 Ankyrin repeats (many copies) Flavodoxin_2 PF02525.17 EFO62650.1 - 4.3e-23 82.0 0.0 5.2e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 EFO62650.1 - 1.5e-06 28.0 0.0 1.8e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_4 PF12682.7 EFO62650.1 - 0.002 17.8 0.0 0.0026 17.5 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin DUF4965 PF16335.5 EFO62650.1 - 0.069 12.8 0.0 0.095 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4965) Flavodoxin_2 PF02525.17 EFO62651.1 - 1e-29 103.7 0.0 1.2e-29 103.4 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 EFO62651.1 - 1.4e-06 28.2 0.0 1.8e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_4 PF12682.7 EFO62651.1 - 0.047 13.4 0.0 0.06 13.1 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin Ank_2 PF12796.7 EFO62653.1 - 5.3e-08 33.4 3.5 7e-05 23.3 1.7 3.8 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62653.1 - 1.3e-05 25.4 0.3 0.02 15.2 0.0 4.2 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62653.1 - 9.4e-05 22.5 6.2 4.6 8.1 0.1 5.2 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 EFO62653.1 - 0.003 18.1 0.8 3.1 8.5 0.0 4.4 4 0 0 4 4 4 1 Ankyrin repeats (many copies) DHHC PF01529.20 EFO62653.1 - 0.0051 16.9 9.6 0.0051 16.9 9.6 3.2 3 0 0 3 3 3 1 DHHC palmitoyltransferase DUF3447 PF11929.8 EFO62653.1 - 0.12 12.4 3.0 1.8 8.6 0.1 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF3447) Ank PF00023.30 EFO62653.1 - 0.72 10.4 6.4 29 5.3 0.2 4.4 3 1 0 3 3 3 0 Ankyrin repeat Metallophos PF00149.28 EFO62654.1 - 5.2e-14 53.2 0.0 1e-13 52.3 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase CNDH2_C PF16858.5 EFO62654.1 - 0.0068 16.3 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term Cyclin_C PF02984.19 EFO62657.1 - 2.2e-13 50.3 0.5 5.7e-13 49.0 0.5 1.7 1 0 0 1 1 1 1 Cyclin, C-terminal domain Cyclin_N PF00134.23 EFO62657.1 - 3.9e-08 33.1 0.0 7.5e-07 28.9 0.0 2.2 1 1 1 2 2 2 2 Cyclin, N-terminal domain Pkinase PF00069.25 EFO62659.1 - 3.7e-18 65.8 0.0 1e-17 64.4 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62659.1 - 3.3e-10 39.7 0.0 7.4e-10 38.5 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 EFO62660.1 - 1.2e-11 43.3 0.3 0.0002 20.7 0.0 4.4 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 EFO62660.1 - 6.3e-10 39.4 0.4 1.1e-08 35.4 0.1 2.5 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EFO62660.1 - 6e-09 35.1 0.8 0.0021 17.8 0.0 3.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_9 PF14658.6 EFO62660.1 - 2e-06 28.0 0.1 1.1e-05 25.7 0.0 2.1 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.6 EFO62660.1 - 2.6e-06 27.2 0.9 0.0081 16.0 0.0 3.7 4 0 0 4 4 4 1 EF-hand domain pair EF-hand_5 PF13202.6 EFO62660.1 - 0.0025 17.2 2.6 0.033 13.7 0.0 3.5 4 0 0 4 4 4 1 EF hand EF-hand_4 PF12763.7 EFO62660.1 - 0.015 15.3 0.4 0.06 13.3 0.0 2.0 2 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 EFO62660.1 - 0.042 14.2 0.1 0.25 11.7 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain EF-hand_11 PF08976.11 EFO62660.1 - 0.047 14.6 0.1 0.097 13.6 0.0 1.5 2 0 0 2 2 2 0 EF-hand domain MMR_HSR1 PF01926.23 EFO62662.1 - 1.2e-11 44.7 0.0 1.6e-10 41.1 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFO62662.1 - 8.5e-05 22.5 1.1 0.026 14.4 1.1 2.5 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EFO62662.1 - 0.00012 21.7 0.1 0.045 13.3 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B Dynamin_N PF00350.23 EFO62662.1 - 0.016 15.3 0.4 0.016 15.3 0.4 2.0 2 1 0 2 2 2 0 Dynamin family Fibrillarin PF01269.17 EFO62662.1 - 0.054 12.6 0.0 0.4 9.8 0.0 2.3 3 0 0 3 3 3 0 Fibrillarin PduV-EutP PF10662.9 EFO62662.1 - 0.14 11.9 0.1 1 9.1 0.0 2.4 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 EFO62662.1 - 0.15 12.4 0.1 26 5.2 0.1 2.4 2 0 0 2 2 2 0 AAA ATPase domain Ank_2 PF12796.7 EFO62663.1 - 2.1e-160 521.7 50.6 2.1e-15 57.0 0.2 17.1 2 2 17 19 19 19 19 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62663.1 - 1.4e-81 267.9 30.7 1.6e-05 25.3 0.1 24.5 15 8 7 24 24 24 19 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62663.1 - 7.7e-79 258.7 44.7 0.00015 21.9 0.0 27.4 7 4 23 31 31 31 24 Ankyrin repeats (many copies) Ank PF00023.30 EFO62663.1 - 2.9e-74 242.5 42.8 0.001 19.4 0.0 32.0 29 3 2 31 31 31 21 Ankyrin repeat Ank_3 PF13606.6 EFO62663.1 - 8.3e-70 222.4 33.9 0.0022 18.3 0.0 32.7 35 0 0 35 35 35 15 Ankyrin repeat Cyclin_N PF00134.23 EFO62663.1 - 0.013 15.2 4.4 5.8 6.7 0.0 6.3 6 1 1 7 7 7 0 Cyclin, N-terminal domain Ank_2 PF12796.7 EFO62664.1 - 8.3e-54 180.1 5.7 4.8e-14 52.7 0.0 7.3 3 2 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62664.1 - 3.2e-36 123.3 5.7 5.7e-09 36.3 0.0 9.9 7 2 3 10 10 10 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62664.1 - 6.5e-30 102.8 10.9 3.5e-06 27.2 0.1 10.1 4 3 5 10 10 10 8 Ankyrin repeats (many copies) Ank PF00023.30 EFO62664.1 - 1.6e-26 91.5 13.0 0.0021 18.5 0.0 10.9 11 0 0 11 11 11 6 Ankyrin repeat Ank_3 PF13606.6 EFO62664.1 - 6.3e-26 87.6 12.6 0.0058 17.0 0.0 11.1 11 0 0 11 11 11 7 Ankyrin repeat TPR_14 PF13428.6 EFO62665.1 - 0.00084 20.0 1.2 12 7.0 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFO62665.1 - 0.02 15.3 1.3 0.62 10.6 0.1 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Cnd3 PF12719.7 EFO62665.1 - 0.14 11.3 1.3 15 4.7 0.8 2.3 2 0 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain NARP1 PF12569.8 EFO62665.1 - 0.48 9.3 2.5 0.29 10.0 0.1 1.8 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 RPN7 PF10602.9 EFO62665.1 - 1 9.0 3.2 16 5.1 0.0 3.5 3 1 1 4 4 4 0 26S proteasome subunit RPN7 HEAT PF02985.22 EFO62666.1 - 0.004 17.3 0.7 2.2 8.7 0.0 4.5 4 0 0 4 4 4 1 HEAT repeat CLASP_N PF12348.8 EFO62666.1 - 0.04 13.5 8.7 0.3 10.6 0.2 3.7 4 0 0 4 4 4 0 CLASP N terminal MEF2_binding PF09047.10 EFO62666.1 - 0.05 13.4 0.6 0.14 12.0 0.6 1.7 1 0 0 1 1 1 0 MEF2 binding GIT1_C PF12205.8 EFO62666.1 - 3.7 7.7 7.8 1.9 8.7 0.2 3.8 4 1 0 4 4 4 0 G protein-coupled receptor kinase-interacting protein 1 C term Ank_2 PF12796.7 EFO62668.1 - 4.6e-57 190.6 6.5 7.1e-20 71.4 0.1 5.4 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62668.1 - 3e-30 103.9 2.7 0.00011 22.4 0.0 8.3 3 2 6 9 9 9 8 Ankyrin repeats (many copies) Ank PF00023.30 EFO62668.1 - 4.4e-27 93.3 1.6 0.00041 20.7 0.0 8.4 8 0 0 8 8 8 6 Ankyrin repeat Ank_4 PF13637.6 EFO62668.1 - 1e-26 92.9 3.8 1.6e-11 44.4 0.1 7.0 6 2 3 9 9 9 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62668.1 - 1.9e-24 83.1 1.0 0.0023 18.3 0.0 9.3 10 0 0 10 10 10 5 Ankyrin repeat DUF737 PF05300.11 EFO62668.1 - 1.2 9.4 14.1 1.1 9.6 10.7 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF737) Ribosomal_L10 PF00466.20 EFO62669.1 - 8.6e-22 77.2 3.3 1.8e-21 76.1 3.3 1.5 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 EFO62669.1 - 2.1e-17 62.9 0.1 3.5e-17 62.2 0.1 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 EFO62669.1 - 8.7e-07 29.4 3.1 8.7e-07 29.4 3.1 2.2 2 0 0 2 2 2 1 60s Acidic ribosomal protein OAD_gamma PF04277.13 EFO62669.1 - 1.4 9.5 5.7 2.3 8.9 2.5 2.2 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain CD20 PF04103.15 EFO62670.1 - 0.028 14.5 0.1 0.08 13.0 0.1 1.8 1 0 0 1 1 1 0 CD20-like family YabA PF06156.13 EFO62670.1 - 0.029 15.0 23.5 1.6 9.5 0.8 4.7 2 1 1 3 3 3 0 Initiation control protein YabA DUF948 PF06103.11 EFO62670.1 - 0.36 11.1 3.7 3.4 8.0 0.4 3.3 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Alanine_zipper PF11839.8 EFO62670.1 - 1 9.7 19.9 7.9 6.9 12.3 3.4 3 0 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein DUF1664 PF07889.12 EFO62670.1 - 1.8 8.6 9.6 16 5.5 0.2 3.6 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 EFO62670.1 - 6.6 6.0 27.5 0.65 9.3 10.4 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) Ank_2 PF12796.7 EFO62672.1 - 5e-34 116.7 3.2 1.4e-09 38.4 0.0 3.9 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO62672.1 - 1e-14 54.5 0.0 8.8e-09 35.1 0.0 2.4 2 1 0 2 2 2 2 Protein kinase domain Ank PF00023.30 EFO62672.1 - 9.9e-11 41.6 0.2 1.9 9.0 0.0 6.5 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 EFO62672.1 - 2.3e-10 40.5 2.6 0.001 19.3 0.0 4.2 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO62672.1 - 1.2e-09 37.9 0.0 1.7e-08 34.1 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Ank_4 PF13637.6 EFO62672.1 - 1.1e-08 35.4 0.1 0.00015 22.3 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62672.1 - 6.6e-08 32.2 0.9 3.9 8.3 0.0 6.3 7 0 0 7 7 7 1 Ankyrin repeat SLATT_4 PF18186.1 EFO62673.1 - 8.6 6.0 6.3 0.59 9.8 0.1 2.3 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 4 DEAD PF00270.29 EFO62674.1 - 4e-44 150.5 0.0 6.7e-44 149.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO62674.1 - 8e-27 93.8 0.0 2.2e-26 92.4 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFO62674.1 - 5.1e-17 61.9 0.1 1.2e-16 60.6 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EFO62674.1 - 0.00032 20.7 0.1 0.0015 18.6 0.0 2.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 EFO62674.1 - 0.077 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 SWI2/SNF2 ATPase Kelch_4 PF13418.6 EFO62675.1 - 3.7e-17 62.0 9.3 5.1e-09 36.0 0.3 4.9 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EFO62675.1 - 4.2e-14 52.3 6.6 2.4e-08 34.0 0.3 5.0 5 1 1 6 6 6 2 Kelch motif Kelch_5 PF13854.6 EFO62675.1 - 5e-13 48.7 12.2 0.0001 22.2 0.1 5.6 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 EFO62675.1 - 2.1e-12 46.4 7.2 1.8e-08 33.8 0.2 4.2 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 EFO62675.1 - 4.4e-10 39.6 8.2 1.5e-07 31.5 0.1 5.7 6 0 0 6 6 6 1 Galactose oxidase, central domain Kelch_2 PF07646.15 EFO62675.1 - 8.7e-10 38.2 6.7 8.9e-07 28.7 0.2 3.9 4 0 0 4 4 4 2 Kelch motif RAG2 PF03089.14 EFO62675.1 - 0.027 13.4 0.0 0.72 8.8 0.0 2.6 3 0 0 3 3 3 0 Recombination activating protein 2 Sortase PF04203.13 EFO62676.1 - 0.025 14.4 0.0 0.041 13.7 0.0 1.4 1 0 0 1 1 1 0 Sortase domain RVT_1 PF00078.27 EFO62680.1 - 1.4e-10 41.1 0.0 2.3e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.6 EFO62680.1 - 1.4e-06 28.6 8.8 0.14 13.0 1.0 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFO62680.1 - 8e-06 26.0 2.5 0.013 15.8 0.9 3.1 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFO62680.1 - 7.9e-05 22.9 3.9 0.57 10.7 0.0 3.5 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_9 PF16293.5 EFO62680.1 - 0.00083 19.2 5.6 0.05 13.4 0.1 3.4 3 0 0 3 3 3 1 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 EFO62680.1 - 0.0017 18.7 5.3 1.3 9.4 1.0 3.3 2 1 1 3 3 3 1 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EFO62680.1 - 0.0032 17.9 11.7 1.4 9.5 0.0 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type Zn-C2H2_12 PF18112.1 EFO62680.1 - 0.025 15.1 4.2 0.87 10.1 0.4 3.1 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain zf-Di19 PF05605.12 EFO62680.1 - 0.047 14.0 8.4 1.6 9.1 0.3 3.4 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_6 PF18450.1 EFO62680.1 - 0.36 10.6 1.5 3.2 7.5 0.2 2.3 2 0 0 2 2 2 0 Zinc Finger domain zf-C2H2_11 PF16622.5 EFO62680.1 - 0.65 9.8 11.3 0.1 12.4 1.1 3.0 3 0 0 3 3 3 0 zinc-finger C2H2-type KptA_kDCL PF18176.1 EFO62681.1 - 0.043 13.7 0.0 0.062 13.2 0.0 1.2 1 0 0 1 1 1 0 KptA in kinetoplastid DICER domain VSP PF03302.13 EFO62682.1 - 4.6e-75 252.9 169.3 1.9e-72 244.4 88.6 4.6 1 1 2 4 4 4 3 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO62682.1 - 0.00083 19.5 34.5 0.0014 18.8 17.3 11.5 3 3 8 12 12 12 3 Furin-like repeat, cysteine-rich VSP PF03302.13 EFO62683.1 - 1.8e-130 435.4 160.7 3.9e-119 398.1 105.2 4.2 1 1 3 4 4 4 3 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO62683.1 - 0.0027 17.8 0.0 0.0069 16.5 0.0 1.7 2 0 0 2 2 2 1 Podoplanin Suppressor_APC PF11414.8 EFO62684.1 - 0.0069 16.4 0.1 0.021 14.9 0.1 1.8 1 0 0 1 1 1 1 Adenomatous polyposis coli tumour suppressor protein Speriolin_N PF15058.6 EFO62684.1 - 0.0077 16.3 0.2 0.019 15.1 0.2 1.6 1 0 0 1 1 1 1 Speriolin N terminus DivIVA PF05103.13 EFO62684.1 - 0.094 12.8 0.0 0.33 11.0 0.0 1.9 1 0 0 1 1 1 0 DivIVA protein Cep57_CLD_2 PF14197.6 EFO62684.1 - 3.5 7.8 9.1 1.7 8.8 0.1 3.9 5 0 0 5 5 5 0 Centrosome localisation domain of PPC89 Pkinase PF00069.25 EFO62685.1 - 1.2e-57 195.3 0.0 1.2e-57 195.3 0.0 2.0 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62685.1 - 6.2e-35 120.7 0.5 1.3e-34 119.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO62685.1 - 2.1e-26 92.3 2.7 6.5e-10 39.5 0.1 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62685.1 - 1.5e-18 66.9 0.3 4.9e-06 27.0 0.0 4.9 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62685.1 - 1.2e-16 60.5 3.1 2.5e-07 30.8 0.0 5.3 2 1 4 6 6 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO62685.1 - 1.4e-10 41.1 2.4 3.8 8.1 0.0 6.1 6 0 0 6 6 6 2 Ankyrin repeat Ank_3 PF13606.6 EFO62685.1 - 1e-07 31.7 0.5 15 6.6 0.0 5.7 5 0 0 5 5 5 0 Ankyrin repeat Kinase-like PF14531.6 EFO62685.1 - 0.00062 19.2 0.0 0.0017 17.8 0.0 1.7 1 0 0 1 1 1 1 Kinase-like Shugoshin_N PF07558.11 EFO62685.1 - 0.0011 18.8 3.6 0.0027 17.5 3.6 1.7 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region HAP1_N PF04849.13 EFO62685.1 - 0.0025 17.1 7.0 0.004 16.4 7.0 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region DUF3138 PF11336.8 EFO62685.1 - 0.0034 16.1 2.1 0.0034 16.1 2.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3138) Rootletin PF15035.6 EFO62685.1 - 0.0071 16.4 7.5 0.012 15.7 7.5 1.2 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion DUF737 PF05300.11 EFO62685.1 - 0.011 16.1 0.8 0.017 15.5 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF737) Spc7 PF08317.11 EFO62685.1 - 0.012 14.6 9.6 0.02 13.8 9.6 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Pkinase_fungal PF17667.1 EFO62685.1 - 0.012 14.4 1.2 0.043 12.6 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 EFO62685.1 - 0.044 13.7 0.3 0.099 12.6 0.0 1.7 2 0 0 2 2 1 0 Phosphotransferase enzyme family APG6_N PF17675.1 EFO62685.1 - 0.11 13.0 7.3 0.21 12.1 7.3 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Tropomyosin_1 PF12718.7 EFO62685.1 - 1 9.5 10.7 1.3 9.1 1.4 2.2 2 0 0 2 2 2 0 Tropomyosin like PRKG1_interact PF15898.5 EFO62685.1 - 1.5 9.8 9.1 3.3 8.7 9.1 1.6 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain bZIP_1 PF00170.21 EFO62685.1 - 2.6 8.2 9.7 0.42 10.7 2.6 3.1 2 1 1 3 3 3 0 bZIP transcription factor TolA_bind_tri PF16331.5 EFO62685.1 - 2.8 8.1 8.1 1.1 9.3 1.8 2.4 2 0 0 2 2 2 0 TolA binding protein trimerisation ADIP PF11559.8 EFO62685.1 - 3 7.9 11.3 0.28 11.3 4.0 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Spc29 PF17082.5 EFO62685.1 - 4.5 7.1 8.9 2.3 8.0 2.1 2.2 1 1 1 2 2 2 0 Spindle Pole Component 29 SlyX PF04102.12 EFO62685.1 - 4.7 7.9 5.3 58 4.4 0.1 2.7 2 0 0 2 2 2 0 SlyX Filament PF00038.21 EFO62685.1 - 5.8 6.4 14.5 27 4.2 12.6 2.4 2 1 0 2 2 2 0 Intermediate filament protein TMF_DNA_bd PF12329.8 EFO62685.1 - 7.1 6.7 14.2 4.9 7.2 5.2 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding MFS_1 PF07690.16 EFO62686.1 - 6e-31 107.6 51.0 6e-31 107.6 51.0 3.2 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_3 PF05977.13 EFO62686.1 - 6.5e-08 31.4 0.5 6.5e-08 31.4 0.5 2.0 3 0 0 3 3 3 1 Transmembrane secretion effector Spc7 PF08317.11 EFO62687.1 - 0.00069 18.6 18.9 0.00069 18.6 18.9 6.4 2 1 2 5 5 5 2 Spc7 kinetochore protein MscS_porin PF12795.7 EFO62687.1 - 0.0017 17.9 8.6 0.0017 17.9 8.6 6.2 2 1 3 6 6 6 2 Mechanosensitive ion channel porin domain SKA1 PF07160.12 EFO62687.1 - 0.0074 16.2 1.5 0.0074 16.2 1.5 7.4 2 2 2 7 7 7 2 Spindle and kinetochore-associated protein 1 DUF3461 PF11944.8 EFO62687.1 - 0.021 15.0 2.1 0.021 15.0 2.1 5.0 5 1 1 6 6 6 0 Protein of unknown function (DUF3461) PKcGMP_CC PF16808.5 EFO62687.1 - 0.19 11.6 7.2 14 5.6 0.4 4.7 2 1 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Peptidase_C10 PF01640.17 EFO62687.1 - 0.98 9.7 2.7 4 7.7 2.7 2.2 1 0 0 1 1 1 0 Peptidase C10 family Ank_2 PF12796.7 EFO62688.1 - 3.7e-31 107.5 2.1 3e-07 30.9 0.0 5.8 3 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62688.1 - 3.5e-19 68.6 6.1 0.0022 18.3 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62688.1 - 5.5e-17 60.1 7.8 0.023 15.2 0.0 9.0 8 1 0 8 8 8 6 Ankyrin repeat Ank_4 PF13637.6 EFO62688.1 - 7.9e-17 61.4 6.4 0.048 14.3 0.2 7.8 6 2 2 9 9 9 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO62688.1 - 1.1e-16 60.4 4.2 0.014 15.8 0.0 8.7 8 0 0 8 8 8 3 Ankyrin repeat Ank_2 PF12796.7 EFO62689.1 - 3.3e-33 114.1 1.1 5e-12 46.3 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62689.1 - 7.4e-22 77.1 3.9 7.3e-05 23.0 0.0 5.8 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO62689.1 - 6.2e-21 73.9 6.1 0.0044 17.4 0.0 6.1 5 1 1 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 EFO62689.1 - 3.4e-18 63.8 5.0 0.086 13.4 0.0 6.7 7 0 0 7 7 7 5 Ankyrin repeat Ank_4 PF13637.6 EFO62689.1 - 2.7e-16 59.7 4.2 0.0006 20.3 0.1 5.1 4 2 1 5 5 5 4 Ankyrin repeats (many copies) zf-C3HC4_3 PF13920.6 EFO62689.1 - 2.3e-05 24.2 6.0 4.6e-05 23.2 6.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO62689.1 - 0.11 12.4 8.3 0.25 11.2 8.3 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 TTL PF03133.15 EFO62691.1 - 6.4e-80 268.4 0.3 2e-79 266.8 0.3 1.7 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EFO62691.1 - 2.6e-05 23.6 0.0 0.001 18.4 0.0 2.6 2 0 0 2 2 2 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EFO62691.1 - 0.00031 20.1 0.0 0.18 11.0 0.0 2.3 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 EFO62691.1 - 0.0021 18.1 0.0 0.0096 16.0 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain Peptidase_M14 PF00246.24 EFO62692.1 - 6.2e-15 55.8 0.0 2.5e-14 53.8 0.0 1.9 2 0 0 2 2 2 1 Zinc carboxypeptidase Pepdidase_M14_N PF18027.1 EFO62692.1 - 5.7e-10 39.5 0.7 1.1e-09 38.5 0.7 1.5 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain AstE_AspA PF04952.14 EFO62692.1 - 0.029 13.5 0.0 4 6.4 0.0 2.2 2 0 0 2 2 2 0 Succinylglutamate desuccinylase / Aspartoacylase family GNAT_acetyltr_2 PF13718.6 EFO62693.1 - 1.9e-82 276.1 0.0 3.4e-82 275.3 0.0 1.4 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.14 EFO62693.1 - 3.5e-51 173.5 0.0 9.9e-51 172.1 0.0 1.8 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.11 EFO62693.1 - 6.8e-28 96.5 0.9 4.5e-27 93.8 0.1 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) tRNA_bind_2 PF13725.6 EFO62693.1 - 2.8e-21 76.3 4.6 2.3e-20 73.3 0.2 3.3 4 0 0 4 4 4 1 Possible tRNA binding domain Kin17_mid PF10357.9 EFO62693.1 - 0.061 13.2 0.7 0.16 11.9 0.0 2.1 2 0 0 2 2 2 0 Domain of Kin17 curved DNA-binding protein Tom37 PF10568.9 EFO62694.1 - 0.1 12.9 2.5 0.52 10.6 0.2 2.8 3 0 0 3 3 3 0 Outer mitochondrial membrane transport complex protein PKcGMP_CC PF16808.5 EFO62694.1 - 2 8.3 8.7 0.72 9.8 0.3 4.5 4 1 1 5 5 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Filament PF00038.21 EFO62694.1 - 8.5 5.9 41.5 25 4.3 41.5 1.9 1 1 0 1 1 1 0 Intermediate filament protein Pkinase PF00069.25 EFO62695.1 - 9.8e-69 231.6 0.0 1.3e-68 231.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62695.1 - 1.7e-37 129.1 0.0 2.8e-37 128.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFO62695.1 - 7.6e-05 21.7 0.1 0.00056 18.8 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EFO62695.1 - 0.0055 16.1 0.0 0.0093 15.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFO62695.1 - 0.035 13.1 0.7 0.071 12.0 0.7 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Kinase-PolyVal PF18762.1 EFO62695.1 - 0.068 13.1 0.4 0.36 10.8 0.1 2.1 1 1 1 2 2 2 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins APH PF01636.23 EFO62695.1 - 1 9.2 4.7 4.9 7.0 0.2 2.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family TruD PF01142.18 EFO62696.1 - 8.3e-40 136.9 0.0 2.1e-36 125.7 0.0 2.9 3 0 0 3 3 3 2 tRNA pseudouridine synthase D (TruD) VCPO_N PF17897.1 EFO62696.1 - 0.16 11.7 0.1 0.45 10.3 0.0 1.7 2 0 0 2 2 2 0 Vanadium chloroperoxidase N-terminal domain VSP PF03302.13 EFO62697.1 - 6.7e-42 143.8 184.0 6.4e-31 107.6 57.1 7.6 1 1 5 6 6 6 6 Giardia variant-specific surface protein Profilin PF00235.19 EFO62697.1 - 0.15 12.4 0.5 0.41 10.9 0.5 1.8 1 0 0 1 1 1 0 Profilin DUF389 PF04087.14 EFO62699.1 - 0.041 13.9 0.0 0.057 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF389) Ank_2 PF12796.7 EFO62700.1 - 2.7e-130 425.2 24.4 4.6e-13 49.6 0.4 13.5 1 1 13 14 14 14 14 Ankyrin repeats (3 copies) Ank PF00023.30 EFO62700.1 - 3.4e-73 239.1 17.9 0.00065 20.0 0.0 22.0 23 0 0 23 23 23 16 Ankyrin repeat Ank_4 PF13637.6 EFO62700.1 - 3.4e-68 225.2 17.5 3e-05 24.5 0.0 18.1 13 5 4 18 18 18 16 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62700.1 - 7.2e-68 223.8 28.5 2.4e-05 24.5 0.2 19.0 5 3 16 21 21 21 18 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62700.1 - 6.8e-61 195.0 17.7 0.017 15.6 0.0 22.3 24 0 0 24 24 24 15 Ankyrin repeat Pkinase PF00069.25 EFO62700.1 - 4.4e-17 62.3 0.0 1e-16 61.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62700.1 - 2.9e-07 30.1 0.0 6.9e-07 28.8 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase 3HCDH_RFF PF18321.1 EFO62700.1 - 0.011 16.2 10.4 1.4e+02 3.0 0.1 8.0 8 1 0 8 8 8 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain Pkinase PF00069.25 EFO62701.1 - 1e-43 149.6 0.0 2.3e-43 148.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62701.1 - 7.3e-14 51.7 0.0 1.4e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PIG-L PF02585.17 EFO62703.1 - 3e-19 70.0 0.1 7.5e-19 68.7 0.1 1.7 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Pkinase PF00069.25 EFO62704.1 - 1.4e-13 50.8 0.0 2.4e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EFO62704.1 - 1.5e-12 47.9 1.0 0.00023 21.7 0.0 4.1 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EFO62704.1 - 5.4e-06 25.9 0.0 8.2e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_3 PF13606.6 EFO62704.1 - 3.2e-05 24.0 4.4 2.8 8.8 0.0 6.2 7 0 0 7 7 7 2 Ankyrin repeat Ank_5 PF13857.6 EFO62704.1 - 5.6e-05 23.3 1.1 0.97 9.8 0.0 3.8 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62704.1 - 9.8e-05 22.8 1.7 1.4 9.6 0.0 5.0 5 1 1 6 6 6 1 Ankyrin repeats (many copies) Ank PF00023.30 EFO62704.1 - 1.8 9.2 4.2 13 6.4 0.0 4.3 4 1 0 4 4 4 0 Ankyrin repeat ArfGap PF01412.18 EFO62705.1 - 3.9e-36 123.7 1.4 3.9e-36 123.7 1.4 2.1 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf zf-B_box PF00643.24 EFO62705.1 - 0.00043 20.4 3.3 0.00071 19.7 3.3 1.3 1 0 0 1 1 1 1 B-box zinc finger MCD PF05292.11 EFO62705.1 - 0.26 10.8 4.8 0.43 10.1 4.8 1.3 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase C-terminal domain FapA PF03961.13 EFO62705.1 - 1.2 7.6 5.2 1.7 7.2 5.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A zf-C4H2 PF10146.9 EFO62705.1 - 3.3 8.0 20.6 0.15 12.3 0.5 2.3 2 0 0 2 2 2 0 Zinc finger-containing protein FliP PF00813.20 EFO62705.1 - 6.6 6.6 8.3 10 5.9 8.3 1.2 1 0 0 1 1 1 0 FliP family ThiF PF00899.21 EFO62706.1 - 2e-48 164.9 1.1 2.4e-48 164.6 1.1 1.0 1 0 0 1 1 1 1 ThiF family UDPG_MGDP_dh_N PF03721.14 EFO62706.1 - 0.0005 19.7 0.7 0.00085 18.9 0.7 1.4 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.20 EFO62706.1 - 0.00054 20.0 0.4 0.00085 19.4 0.4 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 EFO62706.1 - 0.00093 19.6 0.6 0.002 18.5 0.6 1.5 1 1 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox_2 PF07992.14 EFO62706.1 - 0.018 14.3 0.2 0.025 13.8 0.2 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EFO62706.1 - 0.029 14.7 1.5 0.11 12.8 1.5 2.0 1 1 0 1 1 1 0 TrkA-N domain TMEM223 PF14640.6 EFO62706.1 - 0.093 12.9 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 223 Pyr_redox PF00070.27 EFO62706.1 - 0.1 13.2 2.5 11 6.7 0.5 2.4 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFO62706.1 - 0.15 11.6 0.9 0.28 10.7 0.5 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase Ni_hydr_CYTB PF01292.20 EFO62707.1 - 0.08 12.5 0.0 0.099 12.2 0.0 1.1 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 OPA3 PF07047.12 EFO62707.1 - 0.12 12.1 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) DUF2207 PF09972.9 EFO62707.1 - 0.27 10.0 0.5 0.29 9.9 0.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ank_2 PF12796.7 EFO62708.1 - 2.6e-35 120.9 15.9 2.7e-10 40.7 0.0 4.9 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62708.1 - 5e-20 71.6 4.8 2.8e-05 24.6 0.2 6.5 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62708.1 - 7.7e-20 68.9 6.8 0.0021 18.4 0.0 8.4 8 0 0 8 8 8 5 Ankyrin repeat Ank PF00023.30 EFO62708.1 - 2.3e-19 68.9 10.1 0.00072 19.9 0.1 8.3 8 0 0 8 8 8 5 Ankyrin repeat Ank_5 PF13857.6 EFO62708.1 - 6.7e-18 64.5 8.7 0.0063 16.8 0.1 7.0 4 1 4 8 8 8 7 Ankyrin repeats (many copies) UBA_4 PF14555.6 EFO62709.1 - 1.7e-12 47.0 0.1 3e-12 46.1 0.1 1.4 1 0 0 1 1 1 1 UBA-like domain SEP PF08059.13 EFO62709.1 - 0.016 15.8 0.0 0.062 13.9 0.0 2.0 2 0 0 2 2 2 0 SEP domain DNA_pol_lambd_f PF10391.9 EFO62709.1 - 0.14 12.0 0.3 1.4 8.8 0.0 2.6 3 0 0 3 3 3 0 Fingers domain of DNA polymerase lambda Pkinase PF00069.25 EFO62710.1 - 2.6e-67 227.0 0.0 3.2e-67 226.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62710.1 - 7.3e-31 107.4 0.0 1.2e-30 106.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFO62710.1 - 0.026 13.5 0.7 0.061 12.3 0.7 1.7 1 1 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 EFO62710.1 - 0.055 13.1 0.6 0.09 12.4 0.6 1.4 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 EFO62710.1 - 0.11 11.9 0.8 0.16 11.3 0.4 1.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1128 PF06569.11 EFO62710.1 - 0.13 12.3 0.0 0.32 11.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1128) Pkinase_fungal PF17667.1 EFO62710.1 - 0.13 11.0 0.1 0.22 10.3 0.1 1.3 1 0 0 1 1 1 0 Fungal protein kinase zf-UBR PF02207.20 EFO62711.1 - 2e-09 37.4 12.5 2e-09 37.4 12.5 2.8 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) CCB1 PF12046.8 EFO62711.1 - 0.47 9.8 2.1 0.83 9.0 0.1 2.2 2 0 0 2 2 2 0 Cofactor assembly of complex C subunit B RRM_1 PF00076.22 EFO62713.1 - 5.3e-31 106.3 0.1 9.9e-11 41.3 0.0 6.2 6 0 0 6 6 6 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CHAD PF05235.14 EFO62713.1 - 0.045 13.7 3.1 0.067 13.2 0.2 2.5 3 0 0 3 3 3 0 CHAD domain Kelch_4 PF13418.6 EFO62714.1 - 9.7e-11 41.5 0.3 9.2e-06 25.6 0.0 3.8 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_3 PF13415.6 EFO62714.1 - 2.1e-07 31.1 0.9 0.0011 19.2 0.0 4.7 5 1 1 6 6 6 1 Galactose oxidase, central domain Kelch_6 PF13964.6 EFO62714.1 - 1.3e-06 28.5 0.2 1e-05 25.6 0.0 2.7 3 1 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 EFO62714.1 - 1.9e-06 27.7 0.6 0.001 19.0 0.0 2.9 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 EFO62714.1 - 2.1e-05 24.0 0.2 0.057 13.0 0.0 3.4 3 0 0 3 3 3 2 Kelch motif TIP49 PF06068.13 EFO62715.1 - 2.2e-136 454.7 0.9 3e-136 454.3 0.9 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EFO62715.1 - 8.2e-20 70.7 0.0 2.2e-19 69.4 0.0 1.8 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 EFO62715.1 - 2e-07 31.5 1.3 7.7e-05 23.1 0.4 2.7 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFO62715.1 - 4e-07 29.9 0.0 0.0011 18.8 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFO62715.1 - 2.8e-05 24.6 0.3 5.9e-05 23.5 0.3 1.8 1 1 0 1 1 1 1 AAA ATPase domain DnaB_C PF03796.15 EFO62715.1 - 6.9e-05 22.3 0.2 0.00011 21.6 0.2 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_18 PF13238.6 EFO62715.1 - 0.0082 16.7 0.1 0.042 14.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFO62715.1 - 0.009 16.3 0.1 3.8 7.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.6 EFO62715.1 - 0.015 15.8 0.5 0.023 15.2 0.5 1.4 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EFO62715.1 - 0.022 14.4 0.0 3.1 7.5 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 EFO62715.1 - 0.025 13.9 0.1 0.71 9.2 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 EFO62715.1 - 0.029 13.6 0.4 0.08 12.2 0.2 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_25 PF13481.6 EFO62715.1 - 0.051 13.2 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 EFO62716.1 - 5.6e-76 255.4 0.0 1.2e-75 254.3 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62716.1 - 9.8e-43 146.3 0.0 1.5e-42 145.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO62716.1 - 8.9e-08 31.8 0.0 1.3e-06 27.9 0.0 2.2 1 1 0 2 2 2 1 Kinase-like APH PF01636.23 EFO62716.1 - 2.4e-05 24.4 0.2 5.7e-05 23.2 0.2 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EFO62716.1 - 0.0011 18.6 0.3 0.0024 17.5 0.3 1.5 1 0 0 1 1 1 1 RIO1 family KA1 PF02149.19 EFO62716.1 - 0.0026 17.5 1.5 0.0062 16.3 0.0 2.5 3 0 0 3 3 3 1 Kinase associated domain 1 Kdo PF06293.14 EFO62716.1 - 0.015 14.7 0.1 0.027 13.8 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YukC PF10140.9 EFO62716.1 - 0.062 12.1 0.2 0.095 11.5 0.2 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Haspin_kinase PF12330.8 EFO62716.1 - 0.15 11.0 0.8 0.5 9.3 0.8 1.9 1 1 0 1 1 1 0 Haspin like kinase domain LRR_9 PF14580.6 EFO62717.1 - 6.2e-16 58.4 16.4 2.1e-15 56.7 4.9 3.6 2 1 1 3 3 3 3 Leucine-rich repeat LRR_4 PF12799.7 EFO62717.1 - 1.2e-13 51.0 17.4 1.7e-08 34.6 4.6 4.4 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO62717.1 - 1.3e-05 24.9 21.0 0.00017 21.3 7.1 4.8 3 2 2 5 5 5 4 Leucine rich repeat SIMPL PF04402.14 EFO62717.1 - 0.071 13.6 0.4 3.4 8.1 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF541) EcsC PF12787.7 EFO62717.1 - 0.085 12.5 0.1 0.19 11.4 0.1 1.6 1 0 0 1 1 1 0 EcsC protein family DUF760 PF05542.11 EFO62717.1 - 0.095 13.1 0.2 0.33 11.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF760) LRR_1 PF00560.33 EFO62717.1 - 1.2 9.9 18.7 13 6.8 1.9 5.4 4 1 0 4 4 4 0 Leucine Rich Repeat Med29 PF11568.8 EFO62718.1 - 0.0087 16.3 1.3 0.0087 16.3 1.3 2.6 2 2 0 2 2 2 1 Mediator complex subunit 29 DUF16 PF01519.16 EFO62718.1 - 0.039 14.5 2.6 0.039 14.5 2.6 3.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 ADIP PF11559.8 EFO62718.1 - 5.1 7.2 29.1 0.039 14.0 3.9 2.6 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Choline_kinase PF01633.20 EFO62719.1 - 3.4e-23 82.4 0.0 5.3e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EFO62719.1 - 6.1e-10 39.4 0.0 2.1e-09 37.7 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EFO62719.1 - 3.5e-05 23.3 0.0 5.1e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase FeThRed_B PF02943.15 EFO62719.1 - 0.11 12.6 0.1 0.21 11.6 0.1 1.4 1 0 0 1 1 1 0 Ferredoxin thioredoxin reductase catalytic beta chain DUF1679 PF07914.11 EFO62719.1 - 0.13 11.0 0.0 0.2 10.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Ank_2 PF12796.7 EFO62721.1 - 8.5e-62 205.7 23.2 1.4e-13 51.2 0.1 5.7 3 2 5 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62721.1 - 6.6e-32 109.5 6.2 4.6e-07 30.2 0.2 8.7 6 1 3 9 9 9 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62721.1 - 2.8e-29 97.9 1.8 0.065 13.8 0.0 9.6 9 0 0 9 9 9 7 Ankyrin repeat Ank PF00023.30 EFO62721.1 - 9.2e-29 98.6 4.6 0.014 15.8 0.0 8.7 8 0 0 8 8 8 7 Ankyrin repeat Ank_5 PF13857.6 EFO62721.1 - 1.3e-27 95.4 10.3 0.00012 22.3 0.0 8.3 3 2 6 9 9 9 6 Ankyrin repeats (many copies) EcoEI_R_C PF08463.10 EFO62721.1 - 0.0018 18.4 1.5 0.003 17.7 0.3 2.0 2 0 0 2 2 2 1 EcoEI R protein C-terminal CdAMP_rec PF06153.11 EFO62721.1 - 0.021 15.0 0.6 4.1 7.7 0.0 4.1 3 1 1 4 4 4 0 Cyclic-di-AMP receptor FAM76 PF16046.5 EFO62721.1 - 0.78 9.0 6.4 1.3 8.3 6.4 1.3 1 0 0 1 1 1 0 FAM76 protein UPF0242 PF06785.11 EFO62721.1 - 1.7 8.7 7.5 0.27 11.3 3.3 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TBCC_N PF16752.5 EFO62722.1 - 0.07 13.6 0.4 0.13 12.7 0.4 1.4 1 0 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain Asp23 PF03780.13 EFO62723.1 - 0.0048 17.3 0.0 0.01 16.3 0.0 1.5 1 0 0 1 1 1 1 Asp23 family, cell envelope-related function GTP_EFTU PF00009.27 EFO62725.1 - 6.3e-59 198.8 0.0 2.7e-58 196.7 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EFO62725.1 - 1.7e-24 85.9 1.7 2e-23 82.4 0.0 2.8 2 1 1 3 3 3 1 Elongation factor G, domain IV EFG_C PF00679.24 EFO62725.1 - 1.5e-20 73.0 0.0 3.8e-20 71.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EFO62725.1 - 1.7e-14 53.7 0.0 9.8e-14 51.2 0.0 2.2 2 0 0 2 2 2 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EFO62725.1 - 1.2e-10 41.7 0.9 4e-10 40.0 0.1 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFO62725.1 - 0.00076 19.5 0.5 0.0073 16.4 0.2 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFO62725.1 - 0.11 12.6 1.1 0.15 12.1 0.1 1.8 2 0 0 2 2 2 0 Dynamin family Thymidylate_kin PF02223.17 EFO62726.1 - 8e-32 110.4 0.0 1.4e-31 109.6 0.0 1.3 1 0 0 1 1 1 1 Thymidylate kinase PPK2 PF03976.14 EFO62726.1 - 0.046 13.2 0.0 0.071 12.6 0.0 1.2 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) MeaB PF03308.16 EFO62726.1 - 0.054 12.5 0.0 0.078 11.9 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB HEPN_SAV2148 PF18725.1 EFO62726.1 - 0.12 11.7 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 SAV2148-like HEPN DPCD PF14913.6 EFO62731.1 - 1.5e-49 168.0 0.0 1.7e-49 167.8 0.0 1.0 1 0 0 1 1 1 1 DPCD protein family Ribosomal_L13 PF00572.18 EFO62732.1 - 5.2e-07 29.9 0.1 8.6e-05 22.8 0.1 2.3 1 1 0 1 1 1 1 Ribosomal protein L13 NHL PF01436.21 EFO62734.1 - 5e-12 45.2 7.3 0.00021 21.1 0.1 5.6 6 0 0 6 6 6 4 NHL repeat AhpC-TSA PF00578.21 EFO62735.1 - 5e-31 107.2 0.0 7.2e-31 106.7 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFO62735.1 - 7.6e-14 51.7 0.0 1.1e-13 51.2 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EFO62735.1 - 1.1e-08 34.7 0.0 2.6e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin VSP PF03302.13 EFO62738.1 - 1.4e-38 132.8 216.3 2.5e-27 95.7 85.8 8.0 1 1 2 3 3 3 3 Giardia variant-specific surface protein UQ_con PF00179.26 EFO62739.1 - 3.8e-46 156.2 0.0 4.5e-46 156.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFO62739.1 - 0.0074 16.0 0.0 0.01 15.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EFO62739.1 - 0.084 13.2 0.2 0.12 12.6 0.1 1.4 1 1 0 1 1 1 0 RWD domain RSN1_7TM PF02714.15 EFO62740.1 - 8.4e-19 67.9 25.4 8.4e-19 67.9 25.4 3.3 3 2 1 4 4 4 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EFO62740.1 - 1e-08 35.1 8.9 1e-08 35.1 8.9 4.1 3 2 1 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EFO62740.1 - 2.3e-05 24.7 0.5 0.0057 16.9 0.0 2.4 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter TBCC_N PF16752.5 EFO62740.1 - 0.13 12.7 0.2 0.32 11.5 0.2 1.6 1 0 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain WD40 PF00400.32 EFO62741.1 - 9.4e-16 57.9 13.4 0.0082 17.0 0.2 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat Prefoldin_2 PF01920.20 EFO62742.1 - 8.3e-22 77.2 0.7 1e-21 76.9 0.7 1.1 1 0 0 1 1 1 1 Prefoldin subunit DUF2959 PF11172.8 EFO62742.1 - 0.0035 17.5 1.4 0.15 12.2 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2959) DUF503 PF04456.12 EFO62742.1 - 0.014 15.2 0.1 0.059 13.2 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF503) Spc24 PF08286.11 EFO62742.1 - 0.02 15.1 1.1 3.7 7.8 0.0 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Occludin_ELL PF07303.13 EFO62742.1 - 0.029 15.1 0.1 11 6.8 0.0 2.0 2 0 0 2 2 2 0 Occludin homology domain ZapB PF06005.12 EFO62742.1 - 0.034 14.6 0.3 0.11 12.9 0.3 1.8 1 1 0 1 1 1 0 Cell division protein ZapB Pou PF00157.17 EFO62742.1 - 0.089 12.8 0.1 0.64 10.0 0.1 2.1 2 0 0 2 2 2 0 Pou domain - N-terminal to homeobox domain APC_N_CC PF16689.5 EFO62742.1 - 0.42 10.7 3.2 1.6 8.8 0.1 2.4 2 1 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain CH_2 PF06294.11 EFO62743.1 - 5.8e-14 52.0 0.0 1.2e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 EFO62743.1 - 0.016 15.0 0.0 0.041 13.7 0.0 1.6 1 0 0 1 1 1 0 CAMSAP CH domain 4F5 PF04419.14 EFO62744.1 - 4.2e-08 33.9 6.4 4.2e-08 33.9 6.4 2.3 1 1 1 2 2 2 1 4F5 protein family NIF PF03031.18 EFO62746.1 - 2.1e-40 138.1 0.5 3.4e-40 137.4 0.5 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Tctex-1 PF03645.13 EFO62747.1 - 7.6e-31 106.4 0.8 8.5e-31 106.2 0.8 1.0 1 0 0 1 1 1 1 Tctex-1 family DUF1002 PF06207.11 EFO62747.1 - 0.014 14.9 0.2 0.015 14.8 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) Tctex-1 PF03645.13 EFO62748.1 - 1.1e-27 96.2 0.2 1.2e-27 96.1 0.2 1.0 1 0 0 1 1 1 1 Tctex-1 family Bac_rhamnosid_C PF17390.2 EFO62749.1 - 0.042 13.6 0.0 0.19 11.6 0.0 2.0 1 1 0 1 1 1 0 Bacterial alpha-L-rhamnosidase C-terminal domain NPBW PF15180.6 EFO62750.1 - 0.018 14.9 0.0 0.021 14.7 0.0 1.2 1 0 0 1 1 1 0 Neuropeptides B and W Pkinase PF00069.25 EFO62751.1 - 1e-65 221.8 0.1 2.3e-65 220.6 0.1 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62751.1 - 1.9e-43 148.6 0.6 4.1e-43 147.5 0.1 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFO62751.1 - 7e-05 21.8 0.0 7e-05 21.8 0.0 2.9 2 1 1 3 3 3 1 Fungal protein kinase EGF_2 PF07974.13 EFO62752.1 - 2e-27 95.2 296.5 0.00036 20.8 8.7 24.2 20 5 5 25 25 25 17 EGF-like domain EGF_Tenascin PF18720.1 EFO62752.1 - 0.01 15.9 2.8 0.01 15.9 2.8 22.2 24 4 1 25 25 25 0 Tenascin EGF domain Peptidase_C1 PF00112.23 EFO62754.1 - 1.6e-61 208.2 0.7 1.9e-61 208.0 0.7 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFO62754.1 - 1.8e-05 23.7 0.2 0.0012 17.7 0.3 2.0 2 0 0 2 2 2 2 Peptidase C1-like family Zn_protease PF05618.11 EFO62755.1 - 0.055 13.4 0.0 0.095 12.6 0.0 1.7 1 1 0 1 1 1 0 Putative ATP-dependant zinc protease DUF5367 PF17329.2 EFO62755.1 - 0.13 12.4 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5367) VSP PF03302.13 EFO62756.1 - 3.9e-122 407.9 156.4 7.6e-54 183.1 31.3 3.5 1 1 3 4 4 4 4 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO62756.1 - 7 6.7 7.7 0.34 11.0 0.1 2.5 3 0 0 3 3 3 0 Podoplanin Sec23_BS PF08033.12 EFO62757.1 - 5.2e-12 46.3 1.5 1.1e-10 42.1 0.1 2.5 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EFO62757.1 - 0.017 14.9 0.0 0.061 13.1 0.0 1.9 1 0 0 1 1 1 0 Sec23/Sec24 helical domain DUF4200 PF13863.6 EFO62758.1 - 2.1e-12 47.5 19.6 2.1e-12 47.5 19.6 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) RTBV_P46 PF06216.11 EFO62758.1 - 0.066 12.1 1.9 0.093 11.6 1.9 1.3 1 0 0 1 1 1 0 Rice tungro bacilliform virus P46 protein Tweety PF04906.13 EFO62758.1 - 0.14 10.8 2.3 0.1 11.2 0.5 1.6 1 1 0 1 1 1 0 Tweety SNAP PF14938.6 EFO62759.1 - 4.6e-37 128.0 13.1 6.4e-37 127.5 13.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EFO62759.1 - 0.00024 21.3 4.9 0.028 14.7 0.1 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat MIT PF04212.18 EFO62759.1 - 0.012 15.7 12.2 0.021 14.9 1.1 3.4 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Clathrin PF00637.20 EFO62759.1 - 0.02 14.8 3.0 1.3 8.8 0.2 2.8 1 1 0 2 2 2 0 Region in Clathrin and VPS EFG_II PF14492.6 EFO62759.1 - 0.11 12.6 0.3 1.9 8.6 0.0 2.6 3 0 0 3 3 3 0 Elongation Factor G, domain II NSF PF02071.20 EFO62759.1 - 0.25 12.2 0.1 0.25 12.2 0.1 5.1 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat TPR_14 PF13428.6 EFO62759.1 - 0.37 11.7 4.2 6.9 7.8 0.2 4.0 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFO62759.1 - 0.38 11.0 8.4 1.2 9.5 0.5 3.6 3 2 0 3 3 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFO62759.1 - 1.1 9.2 8.1 8.2 6.4 0.2 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFO62759.1 - 2.1 8.5 6.3 12 6.2 0.2 4.5 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFO62759.1 - 7.4 7.1 10.6 17 6.0 1.3 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat VSP PF03302.13 EFO62760.1 - 1.6e-49 168.9 78.6 1.6e-49 168.9 78.6 9.0 2 2 3 7 7 7 1 Giardia variant-specific surface protein EGF PF00008.27 EFO62760.1 - 3.8e-13 49.5 251.6 0.0056 17.0 5.4 25.1 24 0 0 24 24 24 16 EGF-like domain Laminin_EGF PF00053.24 EFO62760.1 - 0.0013 18.8 10.5 0.0013 18.8 10.5 22.4 13 8 8 22 22 22 5 Laminin EGF domain EGF_2 PF07974.13 EFO62760.1 - 0.0014 19.0 24.9 0.0026 18.1 13.2 28.6 26 4 4 30 30 30 15 EGF-like domain hEGF PF12661.7 EFO62760.1 - 0.0085 16.7 4.7 0.0085 16.7 4.7 27.0 28 1 0 28 28 28 8 Human growth factor-like EGF ATP-synt_DE_N PF02823.16 EFO62761.1 - 0.12 12.2 0.0 0.44 10.5 0.0 1.8 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Ribosomal_L30 PF00327.20 EFO62762.1 - 2.8e-17 62.3 0.9 5.1e-17 61.5 0.9 1.4 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 EFO62762.1 - 0.00036 20.7 7.5 0.00069 19.8 7.5 1.5 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Snf7 PF03357.21 EFO62764.1 - 5.4e-09 35.9 20.7 6.3e-09 35.7 20.7 1.1 1 0 0 1 1 1 1 Snf7 BBP1_C PF15272.6 EFO62764.1 - 0.008 16.0 2.1 0.011 15.6 2.1 1.2 1 0 0 1 1 1 1 Spindle pole body component BBP1, C-terminal Mt_ATP_synt PF15704.5 EFO62764.1 - 0.019 14.8 7.8 0.032 14.1 7.6 1.5 1 1 0 1 1 1 0 Mitochondrial ATP synthase subunit JIP_LZII PF16471.5 EFO62764.1 - 0.023 14.9 6.3 0.035 14.3 4.9 2.2 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II COG2 PF06148.11 EFO62764.1 - 0.029 14.4 5.2 0.047 13.8 4.4 1.8 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4407 PF14362.6 EFO62764.1 - 0.033 13.6 6.5 0.043 13.2 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ist1 PF03398.14 EFO62764.1 - 0.12 12.3 7.9 0.99 9.3 7.9 2.2 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway Syntaxin_2 PF14523.6 EFO62764.1 - 0.39 11.1 7.1 3.7 8.0 1.5 2.4 1 1 1 2 2 2 0 Syntaxin-like protein YabA PF06156.13 EFO62764.1 - 3.3 8.4 10.3 4 8.1 1.3 2.5 1 1 1 2 2 2 0 Initiation control protein YabA Ribosomal_L3 PF00297.22 EFO62765.1 - 1.2e-134 449.0 0.1 1.3e-134 448.8 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 Kelch_4 PF13418.6 EFO62766.1 - 6.4e-11 42.1 0.9 0.021 14.8 0.0 5.1 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.25 EFO62766.1 - 1.9e-10 40.1 0.4 0.00023 20.7 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 EFO62766.1 - 1e-09 38.3 4.9 0.00032 20.9 0.1 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 EFO62766.1 - 5.8e-08 32.5 7.5 0.00053 19.9 0.0 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 EFO62766.1 - 2.7e-06 27.5 0.6 0.029 14.7 0.0 5.3 5 2 0 5 5 5 1 Galactose oxidase, central domain Kelch_2 PF07646.15 EFO62766.1 - 0.0037 17.2 3.4 0.36 10.9 0.0 3.6 3 1 0 3 3 3 1 Kelch motif RAG2 PF03089.14 EFO62766.1 - 0.0071 15.4 0.1 0.017 14.1 0.1 1.7 1 1 0 1 1 1 1 Recombination activating protein 2 RSN1_7TM PF02714.15 EFO62767.1 - 4.6e-12 45.8 21.2 4.6e-12 45.8 21.2 2.5 3 1 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EFO62767.1 - 2.4e-08 33.9 6.8 2.4e-08 33.9 6.8 3.2 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport DUF2318 PF10080.9 EFO62768.1 - 0.0025 17.9 0.0 2.4 8.3 0.0 2.2 2 0 0 2 2 2 2 Predicted membrane protein (DUF2318) ADD_ATRX PF17981.1 EFO62768.1 - 0.0072 16.2 0.3 0.55 10.2 0.1 2.3 2 0 0 2 2 2 1 Cysteine Rich ADD domain A2L_zn_ribbon PF08792.10 EFO62768.1 - 0.012 15.3 0.7 0.48 10.2 0.1 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain DUF1451 PF07295.11 EFO62768.1 - 0.018 15.1 0.4 0.42 10.7 0.0 2.2 2 0 0 2 2 2 0 Zinc-ribbon containing domain zf-CpG_bind_C PF12269.8 EFO62768.1 - 0.1 12.4 0.1 0.95 9.2 0.0 2.0 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain Zn-ribbon_8 PF09723.10 EFO62768.1 - 0.13 12.4 0.2 7.7 6.7 0.1 2.3 2 0 0 2 2 2 0 Zinc ribbon domain DNA_RNApol_7kD PF03604.13 EFO62768.1 - 0.19 11.4 1.7 2.7 7.8 0.6 2.2 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Nudix_N_2 PF14803.6 EFO62768.1 - 0.23 11.4 1.6 9.8 6.2 0.4 2.5 2 0 0 2 2 2 0 Nudix N-terminal WD40 PF00400.32 EFO62770.1 - 1.8e-09 38.0 12.3 0.001 19.8 0.0 5.1 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO62770.1 - 1.2e-05 25.6 0.0 0.25 11.7 0.0 4.1 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EFO62770.1 - 0.2 10.2 0.1 0.58 8.6 0.1 1.7 1 1 0 1 1 1 0 Cytochrome D1 heme domain Ank_2 PF12796.7 EFO62771.1 - 7.3e-28 97.0 11.6 4.9e-08 33.4 0.2 4.3 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO62771.1 - 2.3e-12 45.9 0.5 0.22 12.2 0.0 7.1 7 0 0 7 7 7 3 Ankyrin repeat Ank_5 PF13857.6 EFO62771.1 - 1.2e-10 41.4 4.6 0.0029 17.9 0.0 5.5 2 1 4 6 6 6 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO62771.1 - 3.5e-08 33.5 2.0 0.94 10.0 0.0 6.0 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.6 EFO62771.1 - 5.4e-07 30.0 3.9 0.36 11.5 0.1 5.3 6 1 0 6 6 6 3 Ankyrin repeats (many copies) Kinesin PF00225.23 EFO62773.1 - 0.00041 19.4 0.1 0.00085 18.3 0.1 1.5 1 0 0 1 1 1 1 Kinesin motor domain KxDL PF10241.9 EFO62773.1 - 0.049 13.9 5.1 0.35 11.2 2.7 3.4 4 0 0 4 4 4 0 Uncharacterized conserved protein AAA_16 PF13191.6 EFO62773.1 - 0.064 13.6 0.0 0.064 13.6 0.0 3.8 2 1 0 2 2 2 0 AAA ATPase domain MarR_2 PF12802.7 EFO62773.1 - 0.14 12.1 0.4 0.46 10.4 0.4 1.9 1 0 0 1 1 1 0 MarR family MukB PF04310.12 EFO62773.1 - 0.69 9.7 2.9 1.5 8.5 2.9 1.5 1 0 0 1 1 1 0 MukB N-terminal BBIP10 PF14777.6 EFO62774.1 - 0.096 12.3 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 Cilia BBSome complex subunit 10 Med21 PF11221.8 EFO62775.1 - 0.001 19.3 3.1 0.003 17.8 3.1 1.7 1 1 0 1 1 1 1 Subunit 21 of Mediator complex tRNA-synt_1 PF00133.22 EFO62777.1 - 5.7e-194 645.8 0.0 7.2e-194 645.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EFO62777.1 - 3.6e-19 69.2 0.0 8.9e-19 68.0 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EFO62777.1 - 1.6e-15 56.8 0.4 0.00023 20.0 0.0 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EFO62777.1 - 0.0012 18.3 0.0 0.0022 17.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Fer4_12 PF13353.6 EFO62778.1 - 9.9e-08 32.3 0.1 4.3e-07 30.3 0.0 2.0 2 0 0 2 2 2 1 4Fe-4S single cluster domain Radical_SAM PF04055.21 EFO62778.1 - 4.6e-06 27.1 0.2 1e-05 25.9 0.2 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 EFO62778.1 - 0.0012 19.0 0.0 0.0023 18.1 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain CDC50 PF03381.15 EFO62778.1 - 0.039 13.5 0.1 0.057 12.9 0.1 1.2 1 0 0 1 1 1 0 LEM3 (ligand-effect modulator 3) family / CDC50 family S10_plectin PF03501.15 EFO62779.1 - 5.5e-18 64.8 0.0 1.2e-17 63.7 0.0 1.6 1 1 0 1 1 1 1 Plectin/S10 domain DUF2250 PF10007.9 EFO62779.1 - 0.051 13.7 0.4 0.14 12.3 0.4 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) DUF4364 PF14277.6 EFO62779.1 - 0.091 12.5 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) zf-Sec23_Sec24 PF04810.15 EFO62780.1 - 2.1e-08 34.0 5.4 2.1e-08 34.0 5.4 2.1 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Sec23_trunk PF04811.15 EFO62780.1 - 1.7e-06 27.8 0.0 2.8e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Lactamase_B_2 PF12706.7 EFO62782.1 - 1.9e-08 34.1 0.5 0.0005 19.6 0.1 3.1 3 0 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EFO62782.1 - 0.00074 19.6 1.2 0.019 15.0 0.4 2.6 3 0 0 3 3 3 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 EFO62782.1 - 0.005 16.5 0.0 0.021 14.5 0.0 2.1 2 0 0 2 2 2 1 tRNase Z endonuclease zf-RING_2 PF13639.6 EFO62783.1 - 2.6e-08 34.1 2.4 2.6e-08 34.1 2.4 2.9 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.7 EFO62783.1 - 4.8e-08 33.2 1.9 4.8e-08 33.2 1.9 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EFO62783.1 - 1.5e-07 31.1 1.9 1.5e-07 31.1 1.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO62783.1 - 6.4e-06 25.9 1.6 6.4e-06 25.9 1.6 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EFO62783.1 - 9.4e-06 25.6 0.4 9.4e-06 25.6 0.4 2.7 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EFO62783.1 - 3.8e-05 23.4 0.6 3.8e-05 23.4 0.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFO62783.1 - 4.9e-05 23.1 2.5 4.9e-05 23.1 2.5 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFO62783.1 - 0.00067 19.3 5.8 0.0018 18.0 0.2 2.7 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EFO62783.1 - 0.00072 19.5 2.9 0.00072 19.5 2.9 1.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFO62783.1 - 0.0025 17.7 1.3 0.0025 17.7 1.3 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_4 PF14570.6 EFO62783.1 - 0.036 13.9 0.3 0.036 13.9 0.3 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 EFO62783.1 - 0.11 12.7 0.7 0.11 12.7 0.7 2.2 2 0 0 2 2 2 0 RING-variant domain YEATS PF03366.16 EFO62783.1 - 0.16 12.0 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 YEATS family Zn_ribbon_17 PF17120.5 EFO62783.1 - 0.46 10.1 6.4 0.12 12.0 1.4 2.2 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Prok-RING_1 PF14446.6 EFO62783.1 - 0.52 10.3 6.1 29 4.7 0.0 3.5 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 FANCL_C PF11793.8 EFO62783.1 - 5.6 7.2 7.8 2.3 8.5 3.2 2.6 2 1 0 2 2 2 0 FANCL C-terminal domain Hist_deacetyl PF00850.19 EFO62784.1 - 5.6e-81 272.4 0.0 7.4e-81 272.0 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain DUF5491 PF17595.2 EFO62784.1 - 0.11 12.8 0.2 0.36 11.2 0.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5491) zf-UBR PF02207.20 EFO62786.1 - 0.00034 20.7 3.7 0.00034 20.7 3.7 2.9 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) zf-RING_5 PF14634.6 EFO62786.1 - 9.8 6.2 9.1 0.41 10.7 0.4 3.2 2 1 0 2 2 2 0 zinc-RING finger domain Myotub-related PF06602.14 EFO62787.1 - 1.2e-22 80.3 0.0 2.3e-18 66.3 0.0 2.1 2 0 0 2 2 2 2 Myotubularin-like phosphatase domain LRR_8 PF13855.6 EFO62788.1 - 1.5e-12 47.1 1.7 2.2e-06 27.3 0.1 2.6 2 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EFO62788.1 - 5.4e-08 33.0 9.6 7.3e-05 23.1 0.5 3.5 2 2 2 4 4 4 4 Leucine Rich repeats (2 copies) LRRNT_2 PF08263.12 EFO62788.1 - 1.5e-05 25.2 0.5 3.3e-05 24.1 0.5 1.6 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 EFO62788.1 - 6.6e-05 22.9 4.8 0.1 13.2 0.1 5.3 5 1 0 5 5 5 1 Leucine Rich Repeat LRR_6 PF13516.6 EFO62788.1 - 0.0011 18.9 9.1 2.3 8.5 0.1 5.7 6 0 0 6 6 6 2 Leucine Rich repeat LRR_2 PF07723.13 EFO62788.1 - 0.032 14.9 0.2 19 6.1 0.1 3.1 2 0 0 2 2 2 0 Leucine Rich Repeat Nodulin_late PF07127.11 EFO62788.1 - 0.52 10.7 7.7 0.52 10.7 0.2 2.8 2 0 0 2 2 2 0 Late nodulin protein Ank_2 PF12796.7 EFO62789.1 - 2.9e-42 143.1 4.8 2.4e-11 44.0 0.0 5.1 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 EFO62789.1 - 6.4e-26 89.6 0.4 0.0041 17.5 0.1 8.5 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 EFO62789.1 - 1.1e-23 82.9 5.1 1.8e-06 28.1 0.0 7.8 1 1 7 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62789.1 - 1.2e-22 77.6 0.3 0.48 11.1 0.0 8.6 8 0 0 8 8 8 7 Ankyrin repeat Ank_4 PF13637.6 EFO62789.1 - 5.7e-18 65.0 0.6 0.035 14.7 0.0 6.2 4 2 1 6 6 6 5 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO62789.1 - 4.9e-16 58.9 0.0 8.6e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62789.1 - 2.7e-08 33.4 0.0 5.2e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.32 EFO62790.1 - 7.4e-05 23.4 4.3 0.16 12.9 0.0 6.2 7 0 0 7 7 7 1 WD domain, G-beta repeat TMF_DNA_bd PF12329.8 EFO62790.1 - 0.00086 19.2 3.2 0.00086 19.2 3.2 7.0 4 3 3 7 7 7 1 TATA element modulatory factor 1 DNA binding Fez1 PF06818.15 EFO62790.1 - 0.0011 19.4 13.7 0.0011 19.4 13.7 4.4 1 1 2 3 3 3 1 Fez1 Baculo_PEP_C PF04513.12 EFO62790.1 - 0.01 15.8 18.9 0.38 10.8 10.3 3.6 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HPS3_N PF14761.6 EFO62790.1 - 0.031 13.8 0.4 0.22 11.0 0.1 2.5 2 1 0 2 2 2 0 Hermansky-Pudlak syndrome 3 Pox_A_type_inc PF04508.12 EFO62790.1 - 0.034 14.0 4.0 15 5.6 0.2 3.8 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat ANAPC4_WD40 PF12894.7 EFO62790.1 - 0.085 13.2 0.0 2.2 8.6 0.0 3.5 2 2 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Ank_2 PF12796.7 EFO62791.1 - 4.6e-50 168.1 6.6 1.2e-14 54.7 0.0 4.6 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO62791.1 - 2.3e-38 132.1 0.0 5.4e-38 130.9 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Ank_4 PF13637.6 EFO62791.1 - 2.9e-30 104.2 13.1 1.7e-07 31.7 0.0 9.1 6 2 3 9 9 9 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62791.1 - 2.4e-28 97.8 10.5 4.3e-05 23.7 0.0 9.4 4 2 6 10 10 10 8 Ankyrin repeats (many copies) Ank PF00023.30 EFO62791.1 - 3.7e-28 96.7 0.8 0.023 15.2 0.0 9.6 9 0 0 9 9 9 6 Ankyrin repeat Ank_3 PF13606.6 EFO62791.1 - 1.4e-24 83.4 3.3 0.0038 17.6 0.0 9.8 10 0 0 10 10 10 6 Ankyrin repeat Pkinase_Tyr PF07714.17 EFO62791.1 - 3.3e-23 82.3 0.0 5.1e-23 81.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFO62791.1 - 0.014 15.3 0.0 0.031 14.2 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Tcp10_C PF07202.13 EFO62793.1 - 2.2e-21 76.6 1.2 1.5e-20 73.9 0.2 2.8 2 1 0 2 2 2 1 T-complex protein 10 C-terminus MCC-bdg_PDZ PF10506.9 EFO62793.1 - 3.7 7.6 7.4 2.4 8.2 0.6 2.7 2 1 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Fe-ADH PF00465.19 EFO62795.1 - 4.4e-67 226.5 0.8 5.8e-67 226.1 0.8 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EFO62795.1 - 2e-12 47.3 3.1 1.2e-11 44.8 3.1 2.1 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.6 EFO62795.1 - 0.016 14.9 0.2 0.033 13.8 0.1 1.5 2 0 0 2 2 2 0 Periplasmic binding protein PFK PF00365.20 EFO62795.1 - 0.035 13.4 0.1 0.053 12.8 0.1 1.2 1 0 0 1 1 1 0 Phosphofructokinase VSP PF03302.13 EFO62796.1 - 7.8e-33 113.9 167.3 4.9e-19 68.5 16.6 6.8 2 2 5 7 7 7 4 Giardia variant-specific surface protein SKG6 PF08693.10 EFO62796.1 - 3 7.3 5.4 6.9 6.2 5.4 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Fe-ADH PF00465.19 EFO62797.1 - 6.7e-22 77.8 0.0 1.5e-21 76.6 0.0 1.5 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EFO62797.1 - 1.9e-06 27.8 0.0 3.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase CD52 PF15116.6 EFO62797.1 - 0.0024 17.9 1.3 0.0056 16.7 1.3 1.6 1 0 0 1 1 1 1 CAMPATH-1 antigen DHQ_synthase PF01761.20 EFO62797.1 - 0.036 13.2 0.0 0.065 12.4 0.0 1.4 1 0 0 1 1 1 0 3-dehydroquinate synthase EF-hand_6 PF13405.6 EFO62798.1 - 0.0039 17.0 0.0 4.8 7.4 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain DUF5580 PF17743.1 EFO62798.1 - 0.07 11.7 0.0 0.087 11.4 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) EF-hand_1 PF00036.32 EFO62798.1 - 0.077 12.6 0.1 27 4.6 0.0 3.0 3 0 0 3 3 3 0 EF hand Ank_2 PF12796.7 EFO62799.1 - 5.2e-103 337.8 36.5 6.1e-12 46.0 0.2 13.9 3 3 12 15 15 15 15 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62799.1 - 8.8e-60 198.4 21.5 4.4e-05 23.9 0.0 14.8 14 1 1 15 15 15 13 Ankyrin repeats (many copies) Ank PF00023.30 EFO62799.1 - 9e-58 190.3 36.3 0.00095 19.5 0.0 21.4 18 3 4 22 22 22 16 Ankyrin repeat Ank_5 PF13857.6 EFO62799.1 - 9.9e-51 169.2 40.3 0.0047 17.2 0.0 21.0 8 5 13 21 21 21 17 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62799.1 - 2.2e-48 156.6 33.0 0.062 13.9 0.0 22.8 24 0 0 24 24 24 14 Ankyrin repeat LXG PF04740.12 EFO62799.1 - 0.07 12.8 2.1 0.2 11.4 2.1 1.7 1 0 0 1 1 1 0 LXG domain of WXG superfamily Cript PF10235.9 EFO62801.1 - 1 10.0 9.4 0.42 11.2 0.2 3.2 3 0 0 3 3 3 0 Microtubule-associated protein CRIPT Trm112p PF03966.16 EFO62802.1 - 2.3e-12 47.3 0.0 3.1e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Trm112p-like protein PAP_central PF04928.17 EFO62803.1 - 2.9e-26 91.9 0.0 8e-23 80.7 0.0 2.1 2 0 0 2 2 2 2 Poly(A) polymerase central domain NTP_transf_2 PF01909.23 EFO62803.1 - 8.4e-05 22.8 0.0 0.00024 21.4 0.0 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EFO62803.1 - 0.1 12.7 0.0 0.3 11.2 0.0 1.7 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase ADK PF00406.22 EFO62804.1 - 1.3e-23 83.8 0.0 1.6e-23 83.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EFO62804.1 - 5.3e-15 56.0 0.0 9.3e-15 55.2 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFO62804.1 - 3.4e-11 43.5 0.0 4.8e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFO62804.1 - 1.3e-08 35.5 0.0 1.9e-08 34.9 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFO62804.1 - 0.0012 19.1 0.0 0.0019 18.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EFO62804.1 - 0.0072 16.8 0.0 0.011 16.3 0.0 1.5 1 1 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.23 EFO62804.1 - 0.0087 16.1 0.0 0.045 13.8 0.0 2.2 1 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EFO62804.1 - 0.014 15.8 0.2 0.025 15.0 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain Viral_helicase1 PF01443.18 EFO62804.1 - 0.015 15.0 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA PF00004.29 EFO62804.1 - 0.02 15.3 0.1 0.03 14.8 0.1 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 EFO62804.1 - 0.039 12.9 0.0 0.059 12.3 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Thymidylate_kin PF02223.17 EFO62804.1 - 0.044 13.5 0.0 4.5 6.9 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase Ploopntkinase3 PF18751.1 EFO62804.1 - 0.048 13.6 0.0 0.074 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_5 PF07728.14 EFO62804.1 - 0.16 12.0 0.1 0.57 10.2 0.0 1.9 1 1 0 2 2 2 0 AAA domain (dynein-related subfamily) PaRep2a PF07903.11 EFO62805.1 - 0.083 12.7 0.2 0.14 12.0 0.2 1.3 1 0 0 1 1 1 0 PaRep2a protein Ank_2 PF12796.7 EFO62806.1 - 1.8e-97 320.0 28.9 1.1e-15 57.9 0.2 8.8 1 1 8 10 10 10 10 Ankyrin repeats (3 copies) Ank PF00023.30 EFO62806.1 - 1.2e-54 180.5 16.7 0.00056 20.2 0.1 15.9 13 2 2 15 15 15 14 Ankyrin repeat Ank_3 PF13606.6 EFO62806.1 - 1.9e-52 169.1 14.1 0.00055 20.2 0.1 16.0 16 1 0 16 16 16 15 Ankyrin repeat Ank_4 PF13637.6 EFO62806.1 - 4.8e-45 151.4 16.0 2.8e-06 27.8 0.0 12.1 8 3 5 13 13 13 12 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62806.1 - 5.8e-45 150.8 22.7 7.5e-06 26.1 0.4 14.3 7 4 8 15 15 15 13 Ankyrin repeats (many copies) DUF2732 PF10809.8 EFO62806.1 - 0.8 9.6 4.0 1.1 9.1 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2732) DUF5450 PF17529.2 EFO62807.1 - 6.4e-100 331.9 3.3 8.5e-100 331.5 3.3 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5450) Ank_2 PF12796.7 EFO62808.1 - 4.3e-63 209.9 16.7 7e-13 49.0 0.1 7.2 1 1 7 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62808.1 - 8.6e-36 121.9 9.7 4.1e-07 30.4 0.0 7.4 6 2 1 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62808.1 - 5.8e-33 109.2 13.8 0.0067 16.8 0.0 11.9 11 0 0 11 11 11 6 Ankyrin repeat Ank_5 PF13857.6 EFO62808.1 - 1.1e-29 102.1 16.6 3.4e-05 24.1 0.0 10.0 2 2 9 11 11 11 8 Ankyrin repeats (many copies) Ank PF00023.30 EFO62808.1 - 4.1e-22 77.6 22.9 0.0042 17.5 0.0 11.7 11 2 1 12 12 12 6 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO62808.1 - 2.7e-07 30.3 20.7 6.2e-07 29.2 20.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) NinB PF05772.12 EFO62808.1 - 0.02 14.7 0.0 0.041 13.7 0.0 1.5 1 0 0 1 1 1 0 NinB protein Prok-RING_4 PF14447.6 EFO62808.1 - 0.044 13.6 18.2 0.097 12.6 18.2 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Phospholip_B PF04916.13 EFO62809.1 - 9.9e-125 417.1 9.2 1.2e-124 416.8 9.2 1.0 1 0 0 1 1 1 1 Phospholipase B Atx10homo_assoc PF09759.9 EFO62811.1 - 1.3e-07 31.5 0.0 2.3e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain HTH_7 PF02796.15 EFO62815.1 - 1.9e-07 31.0 3.1 6.9e-06 26.0 0.0 3.1 3 0 0 3 3 3 1 Helix-turn-helix domain of resolvase HTH_32 PF13565.6 EFO62815.1 - 1.6e-06 28.6 0.1 8.6e-05 23.1 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 EFO62815.1 - 9.2e-05 22.4 0.0 0.00018 21.5 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 EFO62815.1 - 0.00013 21.7 0.7 0.00092 18.9 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_38 PF13936.6 EFO62815.1 - 0.0031 17.2 3.9 0.029 14.1 0.1 3.0 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_28 PF13518.6 EFO62815.1 - 0.031 14.4 0.0 0.069 13.3 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain DUF3723 PF12520.8 EFO62815.1 - 0.056 12.1 0.0 0.077 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3723) Phage_AlpA PF05930.12 EFO62815.1 - 0.074 12.9 0.0 0.54 10.1 0.0 2.3 2 0 0 2 2 2 0 Prophage CP4-57 regulatory protein (AlpA) HTH_Tnp_4 PF13613.6 EFO62815.1 - 0.18 11.6 2.0 0.54 10.0 0.1 2.2 2 0 0 2 2 2 0 Helix-turn-helix of DDE superfamily endonuclease Radical_SAM_C PF16199.5 EFO62816.1 - 1.1e-21 76.6 0.2 2.1e-21 75.7 0.2 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EFO62816.1 - 4.9e-14 53.0 0.0 1.4e-13 51.6 0.0 1.7 1 0 0 1 1 1 1 Radical SAM superfamily Acetyltransf_10 PF13673.7 EFO62816.1 - 0.001 19.0 0.0 0.002 18.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFO62816.1 - 0.0022 18.2 0.3 0.0045 17.2 0.3 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFO62816.1 - 0.04 13.9 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 FR47-like protein CDC24_OB2 PF17245.2 EFO62816.1 - 0.093 13.3 0.1 0.19 12.3 0.1 1.4 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 2 Pkinase PF00069.25 EFO62818.1 - 1.4e-58 198.3 0.0 2.3e-58 197.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62818.1 - 2.4e-35 122.1 0.2 5.9e-35 120.8 0.2 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EFO62818.1 - 5.1e-15 55.6 0.0 4.9e-06 26.8 0.0 2.6 2 0 0 2 2 2 2 P21-Rho-binding domain Pkinase_fungal PF17667.1 EFO62818.1 - 0.00014 20.8 0.0 0.0002 20.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase KASH_CCD PF14662.6 EFO62819.1 - 1.6e-05 24.8 82.3 0.046 13.5 3.7 5.7 2 1 2 5 5 5 4 Coiled-coil region of CCDC155 or KASH Fez1 PF06818.15 EFO62819.1 - 0.00042 20.8 65.4 0.17 12.3 22.6 4.4 2 1 1 4 4 4 4 Fez1 ERM PF00769.19 EFO62819.1 - 0.0014 18.5 20.9 0.0014 18.5 20.9 4.3 2 1 2 4 4 4 1 Ezrin/radixin/moesin family DUF1664 PF07889.12 EFO62819.1 - 0.0038 17.3 4.2 0.0038 17.3 4.2 6.1 2 2 4 6 6 6 2 Protein of unknown function (DUF1664) Prefoldin PF02996.17 EFO62819.1 - 0.014 15.3 1.9 0.014 15.3 1.9 9.0 5 2 4 10 10 10 0 Prefoldin subunit TSC22 PF01166.18 EFO62819.1 - 0.05 13.9 0.4 0.05 13.9 0.4 9.3 7 3 4 11 11 10 0 TSC-22/dip/bun family DUF3450 PF11932.8 EFO62819.1 - 0.41 9.9 63.8 0.019 14.3 9.9 6.3 1 1 4 6 6 6 0 Protein of unknown function (DUF3450) ATG16 PF08614.11 EFO62819.1 - 0.67 10.1 87.0 1.5 9.0 8.8 6.2 2 1 2 5 5 5 0 Autophagy protein 16 (ATG16) Filament PF00038.21 EFO62819.1 - 2.3 7.7 68.9 2.4 7.7 14.0 3.5 1 1 2 3 3 3 0 Intermediate filament protein Spc7 PF08317.11 EFO62819.1 - 2.7 6.8 79.7 0.49 9.2 11.7 5.2 1 1 5 6 6 6 0 Spc7 kinetochore protein DUF1515 PF07439.11 EFO62819.1 - 2.9 7.9 26.0 0.47 10.5 1.9 5.2 3 2 2 5 5 5 0 Protein of unknown function (DUF1515) CENP-F_leu_zip PF10473.9 EFO62819.1 - 5.7 7.0 89.6 0.3 11.1 11.5 6.5 2 2 4 6 6 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 OmpH PF03938.14 EFO62819.1 - 5.7 7.3 63.4 0.12 12.8 6.3 6.2 2 1 3 5 5 4 0 Outer membrane protein (OmpH-like) UPF0242 PF06785.11 EFO62819.1 - 6.2 6.9 74.9 0.042 14.0 9.9 5.5 1 1 2 4 4 4 0 Uncharacterised protein family (UPF0242) N-terminus FPP PF05911.11 EFO62819.1 - 8.9 4.4 81.9 4.9 5.2 25.4 4.0 1 1 2 3 3 3 0 Filament-like plant protein, long coiled-coil Atg14 PF10186.9 EFO62820.1 - 0.0062 15.7 4.0 0.0096 15.0 4.0 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1843 PF08898.10 EFO62820.1 - 0.12 12.9 0.6 0.77 10.3 0.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1843) ATG16 PF08614.11 EFO62820.1 - 0.31 11.2 5.3 0.061 13.5 1.9 1.6 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 EFO62820.1 - 0.41 9.5 5.7 0.68 8.8 5.7 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Ras PF00071.22 EFO62821.1 - 1.5e-56 190.4 0.0 1.9e-56 190.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFO62821.1 - 9.1e-31 106.6 0.0 1.5e-30 105.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFO62821.1 - 2e-11 43.6 0.0 2.7e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFO62821.1 - 0.00037 20.6 0.0 0.00059 19.9 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFO62821.1 - 0.013 15.4 0.1 5.9 6.8 0.0 2.8 1 1 2 3 3 3 0 RsgA GTPase GTP_EFTU PF00009.27 EFO62821.1 - 0.038 13.5 0.0 0.15 11.5 0.0 2.0 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Big_4 PF07532.11 EFO62821.1 - 0.095 12.5 0.1 0.18 11.6 0.1 1.4 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 4) DNA_pol_E_B PF04042.16 EFO62821.1 - 0.21 10.9 0.0 0.31 10.4 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B Metallophos PF00149.28 EFO62825.1 - 3.2e-34 119.2 0.2 4.7e-34 118.7 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFO62825.1 - 0.05 14.1 0.0 0.1 13.1 0.0 1.6 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Metallophos PF00149.28 EFO62826.1 - 2.7e-35 122.7 0.1 3.8e-35 122.2 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Galanin PF01296.18 EFO62826.1 - 0.13 12.2 0.0 0.38 10.8 0.0 1.7 1 0 0 1 1 1 0 Galanin FKBP_C PF00254.28 EFO62827.1 - 1.9e-36 124.3 0.0 2.2e-36 124.1 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N_2 PF18023.1 EFO62827.1 - 0.06 13.4 0.0 0.39 10.8 0.0 1.9 1 1 0 1 1 1 0 BDBT FKBP like N-terminal Dynactin PF12455.8 EFO62828.1 - 0.086 12.1 0.1 5.5 6.1 0.1 2.1 1 1 1 2 2 2 0 Dynein associated protein CH_2 PF06294.11 EFO62829.1 - 3.2e-12 46.4 0.0 9.6e-12 44.9 0.0 1.9 1 0 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 EFO62829.1 - 0.027 14.3 0.0 0.12 12.2 0.0 2.1 2 0 0 2 2 2 0 CAMSAP CH domain UPF0515 PF15135.6 EFO62830.1 - 0.018 14.4 3.4 0.93 8.8 0.4 2.4 2 0 0 2 2 2 0 Uncharacterised protein UPF0515 TPR_19 PF14559.6 EFO62831.1 - 0.00081 19.8 0.0 5.9 7.5 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFO62831.1 - 0.013 15.5 0.2 0.22 11.7 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat WD40 PF00400.32 EFO62832.1 - 2.2e-12 47.3 5.6 0.0043 17.9 0.1 8.4 7 1 0 7 7 7 2 WD domain, G-beta repeat PQQ_3 PF13570.6 EFO62832.1 - 0.0058 17.1 3.1 57 4.4 0.1 5.5 6 0 0 6 6 6 1 PQQ-like domain PQQ_2 PF13360.6 EFO62832.1 - 0.11 12.1 1.0 0.79 9.3 0.1 2.5 1 1 1 3 3 3 0 PQQ-like domain Fcf1 PF04900.12 EFO62833.1 - 1.6e-28 99.0 0.1 2.3e-28 98.5 0.1 1.2 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 EFO62833.1 - 3.5e-12 46.7 0.0 5.8e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 PIN like domain Jnk-SapK_ap_N PF09744.9 EFO62834.1 - 0.0063 16.8 15.6 0.0091 16.2 3.5 3.2 2 1 0 3 3 3 1 JNK_SAPK-associated protein-1 DUF1664 PF07889.12 EFO62834.1 - 0.11 12.5 17.1 0.64 10.1 3.3 3.2 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) OmpH PF03938.14 EFO62834.1 - 0.56 10.5 7.6 5.1 7.4 2.3 2.7 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) LPP PF04728.13 EFO62834.1 - 1.1 9.7 5.0 15 6.1 0.2 3.4 3 0 0 3 3 3 0 Lipoprotein leucine-zipper Fez1 PF06818.15 EFO62834.1 - 3.1 8.2 14.3 4.5 7.7 0.8 2.7 2 1 0 2 2 2 0 Fez1 DUF4407 PF14362.6 EFO62834.1 - 3.4 6.9 13.5 0.28 10.5 2.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) Syntaxin-6_N PF09177.11 EFO62834.1 - 4 8.1 14.4 2.4 8.8 3.4 3.4 2 1 1 3 3 3 0 Syntaxin 6, N-terminal TPR_MLP1_2 PF07926.12 EFO62834.1 - 7.3 6.7 19.2 5.5 7.1 6.7 3.4 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein ZapB PF06005.12 EFO62835.1 - 0.0039 17.6 5.0 0.0039 17.6 5.0 4.6 1 1 4 5 5 5 2 Cell division protein ZapB Fungal_TACC PF12709.7 EFO62835.1 - 0.034 14.6 1.5 0.034 14.6 1.5 4.4 1 1 3 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins HALZ PF02183.18 EFO62835.1 - 0.063 13.5 1.4 0.063 13.5 1.4 5.4 7 0 0 7 7 7 0 Homeobox associated leucine zipper HMMR_C PF15908.5 EFO62835.1 - 0.42 10.9 21.1 0.15 12.3 4.4 3.0 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor C-terminal bZIP_1 PF00170.21 EFO62835.1 - 1.5 8.9 26.6 0.39 10.9 0.2 5.3 1 1 4 5 5 5 0 bZIP transcription factor TPR_MLP1_2 PF07926.12 EFO62835.1 - 3.3 7.8 36.0 8.2 6.5 14.5 3.2 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein FlaC_arch PF05377.11 EFO62835.1 - 3.9 7.9 18.6 9.2 6.8 0.4 4.7 2 2 1 4 4 4 0 Flagella accessory protein C (FlaC) THOC7 PF05615.13 EFO62835.1 - 4.3 7.6 35.0 2.9 8.2 4.3 4.1 1 1 2 3 3 3 0 Tho complex subunit 7 DUF1542 PF07564.11 EFO62835.1 - 5.1 7.3 9.4 1.4 9.0 2.8 2.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) CtIP_N PF10482.9 EFO62835.1 - 6.3 6.9 24.3 5 7.2 7.3 3.3 1 1 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain HOOK PF05622.12 EFO62835.1 - 8.4 4.4 37.2 2.3 6.3 5.3 2.1 1 1 1 2 2 2 0 HOOK protein Ank_2 PF12796.7 EFO62836.1 - 1.4e-12 48.0 2.4 8.6e-11 42.3 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO62836.1 - 1.4e-05 25.1 6.9 0.043 14.4 0.0 5.3 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 EFO62836.1 - 5.8e-05 23.3 4.7 0.0018 18.5 0.1 4.2 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62836.1 - 0.00011 22.6 4.0 0.0047 17.5 0.3 3.8 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 EFO62836.1 - 0.00017 21.8 4.0 4.8 7.8 0.1 5.2 5 0 0 5 5 5 2 Ankyrin repeat Pkinase PF00069.25 EFO62837.1 - 3.5e-24 85.6 0.0 2.7e-23 82.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62837.1 - 5.8e-15 55.3 0.1 1.1e-14 54.3 0.1 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFO62837.1 - 0.054 13.4 0.5 0.63 9.9 0.1 2.5 1 1 2 3 3 3 0 Phosphotransferase enzyme family DUF1679 PF07914.11 EFO62837.1 - 0.14 11.0 0.0 0.32 9.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) WzyE PF06899.11 EFO62837.1 - 0.26 10.2 0.0 0.37 9.7 0.0 1.1 1 0 0 1 1 1 0 WzyE protein, O-antigen assembly polymerase EGF PF00008.27 EFO62838.1 - 6.7e-09 35.9 112.8 0.0071 16.6 10.1 11.3 11 1 0 11 11 11 7 EGF-like domain EGF_2 PF07974.13 EFO62838.1 - 3.6e-08 33.6 119.6 0.041 14.3 7.7 10.6 9 2 1 10 10 10 8 EGF-like domain Plasmod_Pvs28 PF06247.11 EFO62838.1 - 1.2e-05 25.4 15.3 0.00012 22.3 3.5 9.5 7 1 1 8 8 8 2 Pvs28 EGF domain EGF_CA PF07645.15 EFO62838.1 - 0.0083 16.3 8.8 0.0083 16.3 8.8 10.5 8 3 2 10 10 10 4 Calcium-binding EGF domain hEGF PF12661.7 EFO62838.1 - 0.013 16.1 23.2 0.016 15.9 8.7 13.4 15 1 1 16 16 16 0 Human growth factor-like EGF VSP PF03302.13 EFO62839.1 - 1.5e-83 280.9 131.5 1.5e-45 155.7 31.2 4.1 1 1 3 4 4 4 4 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO62839.1 - 0.038 14.1 1.0 0.11 12.6 1.0 1.8 1 0 0 1 1 1 0 Podoplanin SKG6 PF08693.10 EFO62839.1 - 0.46 9.9 4.8 1.1 8.7 4.8 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Acetyltransf_10 PF13673.7 EFO62840.1 - 5.7e-16 58.6 0.0 6.9e-16 58.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFO62840.1 - 6.8e-12 45.7 0.1 1.2e-11 44.9 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFO62840.1 - 4e-09 36.7 0.0 5.3e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFO62840.1 - 0.00028 20.8 0.0 0.00053 19.9 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EFO62840.1 - 0.0032 17.5 0.0 0.013 15.6 0.0 1.8 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFO62840.1 - 0.0041 17.2 0.0 0.01 15.9 0.0 1.7 1 1 1 2 2 2 1 GCN5-related N-acetyl-transferase ACPS PF01648.20 EFO62840.1 - 0.031 14.4 0.0 0.037 14.1 0.0 1.1 1 0 0 1 1 1 0 4'-phosphopantetheinyl transferase superfamily Acetyltransf_13 PF13880.6 EFO62840.1 - 0.081 12.9 0.0 0.37 10.8 0.0 1.9 1 1 1 2 2 2 0 ESCO1/2 acetyl-transferase PanZ PF12568.8 EFO62840.1 - 0.087 12.6 0.1 0.93 9.2 0.0 2.2 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain, PanZ Ank_2 PF12796.7 EFO62841.1 - 6.4e-53 177.3 13.6 2.3e-13 50.5 0.3 5.7 1 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO62841.1 - 2.6e-31 104.2 5.0 0.004 17.5 0.0 10.4 9 1 1 10 10 10 8 Ankyrin repeat Ank_5 PF13857.6 EFO62841.1 - 4.3e-29 100.2 15.3 1.9e-05 24.8 0.0 8.9 1 1 7 9 9 9 8 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62841.1 - 4.3e-29 100.5 11.1 7.9e-06 26.3 0.1 7.2 7 1 0 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO62841.1 - 2.6e-24 84.5 12.5 0.0041 17.5 0.0 10.6 10 1 1 11 11 11 8 Ankyrin repeat Pkinase PF00069.25 EFO62841.1 - 3.5e-23 82.3 0.0 9e-23 81.0 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62841.1 - 3.1e-15 56.2 0.0 7.5e-15 54.9 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase Nucleoporin2 PF04096.14 EFO62843.1 - 5.8e-23 81.7 0.0 9.7e-23 80.9 0.0 1.3 1 1 0 1 1 1 1 Nucleoporin autopeptidase NYD-SP28_assoc PF14775.6 EFO62844.1 - 7e-19 67.7 3.1 7e-19 67.7 3.1 4.3 5 1 0 5 5 5 1 Sperm tail C-terminal domain NYD-SP28 PF14772.6 EFO62844.1 - 1.7e-15 56.9 2.0 1.7e-15 56.9 2.0 4.7 4 0 0 4 4 4 1 Sperm tail NPHI_C PF08469.10 EFO62844.1 - 0.15 12.0 1.3 1.2 9.0 0.1 2.6 2 0 0 2 2 2 0 Nucleoside triphosphatase I C-terminal YabA PF06156.13 EFO62844.1 - 0.57 10.9 0.1 0.57 10.9 0.1 4.3 3 1 0 3 3 3 0 Initiation control protein YabA Ribosomal_S17e PF00833.18 EFO62845.1 - 1.9e-49 166.6 1.4 2.2e-49 166.4 1.4 1.0 1 0 0 1 1 1 1 Ribosomal S17 SRI PF08236.11 EFO62845.1 - 0.043 14.0 0.3 0.079 13.1 0.3 1.3 1 0 0 1 1 1 0 SRI (Set2 Rpb1 interacting) domain Ribosomal_L29 PF00831.23 EFO62847.1 - 1.2e-16 60.4 1.9 1.3e-16 60.2 0.2 1.8 2 0 0 2 2 2 1 Ribosomal L29 protein DUF1192 PF06698.11 EFO62847.1 - 0.026 14.5 1.4 0.047 13.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) MFS_1 PF07690.16 EFO62848.1 - 3.8e-23 82.0 34.7 2.8e-16 59.4 11.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ECF-ribofla_trS PF07155.12 EFO62848.1 - 0.0035 17.4 5.5 0.0035 17.4 5.5 4.2 3 2 1 4 4 4 1 ECF-type riboflavin transporter, S component Plasmid_RAQPRD PF09686.10 EFO62849.1 - 0.0073 16.5 0.3 0.012 15.8 0.3 1.3 1 0 0 1 1 1 1 Plasmid protein of unknown function (Plasmid_RAQPRD) GOLGA2L5 PF15070.6 EFO62849.1 - 0.025 13.2 0.6 0.028 13.1 0.6 1.0 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 stn_TNFRSF12A PF12191.8 EFO62849.1 - 0.12 12.6 0.0 0.15 12.3 0.0 1.1 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain zf-HIT PF04438.16 EFO62850.1 - 2.2e-09 37.0 7.5 4.2e-09 36.1 7.5 1.5 1 0 0 1 1 1 1 HIT zinc finger zf-B_box PF00643.24 EFO62850.1 - 0.29 11.3 5.9 0.56 10.4 5.9 1.5 1 0 0 1 1 1 0 B-box zinc finger Ribosomal_L24e PF01246.20 EFO62851.1 - 1.6e-21 76.3 0.1 3.3e-21 75.3 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L24e TraC PF07820.12 EFO62851.1 - 0.044 14.1 0.4 0.058 13.7 0.4 1.2 1 0 0 1 1 1 0 TraC-like protein PHZA_PHZB PF03284.13 EFO62851.1 - 0.083 12.5 0.1 0.65 9.6 0.0 2.1 1 1 1 2 2 2 0 Phenazine biosynthesis protein A/B Pkinase PF00069.25 EFO62852.1 - 6.4e-63 212.6 0.0 8.3e-63 212.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62852.1 - 8.7e-39 133.4 0.1 5.9e-38 130.6 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO62852.1 - 3.7e-05 23.2 0.5 0.37 10.1 0.0 3.1 2 1 1 3 3 3 2 Kinase-like Haspin_kinase PF12330.8 EFO62852.1 - 0.00024 20.1 0.7 0.00038 19.5 0.7 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFO62852.1 - 0.02 14.2 0.1 0.03 13.7 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFO62852.1 - 0.16 11.8 0.0 1.1 9.2 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family LRIF1 PF15741.5 EFO62853.1 - 0.35 9.4 10.9 0.4 9.2 10.9 1.0 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 DUF3500 PF12006.8 EFO62853.1 - 2.1 7.8 8.5 2.7 7.4 8.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) TEX13 PF15186.6 EFO62853.1 - 3.3 7.4 17.9 0.27 10.9 11.8 2.1 1 1 1 2 2 2 0 Testis-expressed sequence 13 protein family RR_TM4-6 PF06459.12 EFO62853.1 - 3.7 7.3 15.2 5.1 6.8 15.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3660 PF12398.8 EFO62854.1 - 0.029 14.4 0.7 2.5 8.2 0.1 2.4 2 0 0 2 2 2 0 Receptor serine/threonine kinase Ax_dynein_light PF10211.9 EFO62855.1 - 1.6e-80 269.5 9.1 1.6e-80 269.5 9.1 1.5 2 0 0 2 2 2 1 Axonemal dynein light chain Lzipper-MIP1 PF14389.6 EFO62855.1 - 0.0061 16.8 8.2 0.098 13.0 0.1 3.5 3 0 0 3 3 3 1 Leucine-zipper of ternary complex factor MIP1 BST2 PF16716.5 EFO62855.1 - 0.0078 16.8 0.6 0.0078 16.8 0.6 3.4 4 0 0 4 4 4 1 Bone marrow stromal antigen 2 Zn_protease PF05618.11 EFO62855.1 - 0.0092 15.9 0.2 0.035 14.0 0.0 2.0 2 0 0 2 2 2 1 Putative ATP-dependant zinc protease End3 PF12761.7 EFO62855.1 - 0.021 15.0 4.4 0.021 15.0 4.4 2.1 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 MCC-bdg_PDZ PF10506.9 EFO62855.1 - 0.025 14.6 1.0 0.025 14.6 1.0 2.4 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Herpes_BLRF2 PF05812.12 EFO62855.1 - 0.026 14.7 3.1 0.026 14.7 3.1 1.9 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein DUF4164 PF13747.6 EFO62855.1 - 0.056 13.7 10.0 0.31 11.4 7.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Snapin_Pallidin PF14712.6 EFO62855.1 - 0.22 11.9 10.8 0.1 13.0 6.7 2.2 2 0 0 2 2 2 0 Snapin/Pallidin HALZ PF02183.18 EFO62855.1 - 0.28 11.4 7.7 0.29 11.4 2.4 2.7 2 0 0 2 2 2 0 Homeobox associated leucine zipper TSNAXIP1_N PF15739.5 EFO62855.1 - 2.1 8.8 15.4 0.15 12.4 3.3 2.7 2 1 1 3 3 3 0 Translin-associated factor X-interacting N-terminus CCDC-167 PF15188.6 EFO62855.1 - 2.7 8.4 9.3 7.4 7.0 9.3 1.7 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF4407 PF14362.6 EFO62855.1 - 4.2 6.6 12.7 7.8 5.8 5.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Striatin PF08232.12 EFO62855.1 - 6.7 7.3 14.4 4.8 7.8 8.8 2.3 2 0 0 2 2 2 0 Striatin family IU_nuc_hydro PF01156.19 EFO62856.1 - 1.4e-46 159.5 0.0 1.7e-46 159.2 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase zf-HC5HC2H PF13771.6 EFO62857.1 - 2.1e-10 40.7 8.6 1.7e-09 37.8 1.9 3.4 4 0 0 4 4 4 2 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EFO62857.1 - 9.9e-07 28.9 8.7 1.8e-05 24.9 2.8 3.2 3 0 0 3 3 3 2 PHD-zinc-finger like domain DNA_gyraseA_C PF03989.13 EFO62860.1 - 0.011 15.1 0.1 0.042 13.3 0.0 2.0 2 0 0 2 2 2 0 DNA gyrase C-terminal domain, beta-propeller Pecanex_C PF05041.15 EFO62861.1 - 5.7e-06 26.1 0.0 1.4e-05 24.8 0.0 1.6 1 1 0 1 1 1 1 Pecanex protein (C-terminus) DUF2870 PF11069.8 EFO62862.1 - 1.8e-08 34.7 0.0 3e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2870) LRR_8 PF13855.6 EFO62863.1 - 3.7e-15 55.4 16.4 6.9e-08 32.1 0.1 4.1 2 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFO62863.1 - 5.2e-11 42.6 29.9 0.00016 22.0 4.2 5.3 2 1 6 8 8 8 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFO62863.1 - 1.4e-09 37.6 6.6 8.6e-05 22.1 1.3 3.5 3 1 1 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 EFO62863.1 - 0.00044 20.1 13.5 4.7 7.5 0.3 5.9 5 0 0 5 5 5 3 Leucine Rich repeat LRR_1 PF00560.33 EFO62863.1 - 0.15 12.7 26.3 17 6.4 0.1 6.8 6 0 0 6 6 6 0 Leucine Rich Repeat VSP PF03302.13 EFO62864.1 - 7.1e-96 321.5 309.5 9.4e-42 143.3 27.5 9.8 1 1 7 9 9 9 8 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO62864.1 - 0.12 12.5 0.0 0.51 10.4 0.0 2.2 1 0 0 1 1 1 0 Podoplanin SKG6 PF08693.10 EFO62864.1 - 0.62 9.5 3.3 1.2 8.6 3.3 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain hEGF PF12661.7 EFO62865.1 - 0.00013 22.5 3.7 0.00013 22.5 3.7 12.3 12 3 0 12 12 12 3 Human growth factor-like EGF EGF_2 PF07974.13 EFO62865.1 - 0.0006 20.1 23.1 0.0016 18.8 8.8 12.5 11 3 1 12 12 12 4 EGF-like domain EGF PF00008.27 EFO62865.1 - 0.0031 17.8 2.9 0.0031 17.8 2.9 11.7 12 3 0 12 12 12 4 EGF-like domain DUF4748 PF15932.5 EFO62865.1 - 0.072 12.8 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) Ank_2 PF12796.7 EFO62866.1 - 1.1e-75 250.3 21.2 2.6e-14 53.5 0.2 6.9 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO62866.1 - 2.8e-47 161.3 0.1 9.4e-47 159.6 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Ank_4 PF13637.6 EFO62866.1 - 1.2e-46 156.5 13.1 8.2e-09 35.8 0.2 8.7 8 1 0 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62866.1 - 2e-45 152.3 17.1 3.3e-06 27.3 0.1 10.8 3 2 7 10 10 10 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62866.1 - 8.3e-41 133.3 12.8 0.00091 19.5 0.2 13.3 12 1 1 13 13 12 7 Ankyrin repeat Ank PF00023.30 EFO62866.1 - 1.1e-38 130.0 20.6 0.00022 21.6 0.1 13.5 15 0 0 15 15 13 8 Ankyrin repeat Pkinase_Tyr PF07714.17 EFO62866.1 - 3.1e-28 98.8 0.0 1.4e-27 96.6 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EFO62866.1 - 0.00075 19.5 0.0 0.0015 18.5 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFO62866.1 - 0.0015 18.2 0.9 0.0038 16.8 0.0 2.1 2 1 0 2 2 2 1 Choline/ethanolamine kinase DUF1664 PF07889.12 EFO62866.1 - 0.017 15.1 2.6 0.056 13.5 2.6 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DHquinase_I PF01487.15 EFO62866.1 - 0.023 14.9 8.9 0.14 12.4 1.4 3.3 2 1 1 3 3 3 0 Type I 3-dehydroquinase Lebercilin PF15619.6 EFO62866.1 - 0.028 14.1 9.2 0.089 12.4 9.2 1.9 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Cep57_CLD_2 PF14197.6 EFO62866.1 - 0.043 13.9 2.2 0.22 11.6 2.2 2.3 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 Baculo_gp64 PF03273.13 EFO62866.1 - 0.044 12.6 3.5 1.3 7.7 1.1 2.5 2 1 0 2 2 2 0 Baculovirus gp64 envelope glycoprotein family Cnd1 PF12717.7 EFO62866.1 - 0.05 13.7 0.5 3 7.9 0.0 3.8 3 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Spc24 PF08286.11 EFO62866.1 - 0.13 12.5 6.8 0.11 12.7 4.1 2.4 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Seryl_tRNA_N PF02403.22 EFO62866.1 - 0.14 12.4 2.3 0.62 10.3 2.3 2.1 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain FlaC_arch PF05377.11 EFO62866.1 - 0.18 12.2 2.7 0.29 11.5 0.6 2.6 2 0 0 2 2 1 0 Flagella accessory protein C (FlaC) Spc7 PF08317.11 EFO62866.1 - 0.2 10.5 9.6 0.44 9.4 9.6 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein PTS_IIA PF02255.16 EFO62866.1 - 1.1 9.3 6.0 0.61 10.2 1.0 3.2 2 1 1 3 3 3 0 PTS system, Lactose/Cellobiose specific IIA subunit Syntaxin-6_N PF09177.11 EFO62866.1 - 1.2 9.8 5.5 9.4 6.9 5.5 2.5 1 1 0 1 1 1 0 Syntaxin 6, N-terminal bZIP_1 PF00170.21 EFO62866.1 - 1.2 9.3 10.5 9.1 6.5 0.3 3.7 2 1 1 3 3 3 0 bZIP transcription factor DUF641 PF04859.12 EFO62866.1 - 1.5 9.2 5.5 0.7 10.2 2.6 2.0 2 0 0 2 2 1 0 Plant protein of unknown function (DUF641) Fez1 PF06818.15 EFO62866.1 - 1.7 9.1 13.2 0.28 11.6 8.9 1.9 2 0 0 2 2 1 0 Fez1 Med9 PF07544.13 EFO62866.1 - 4.1 7.6 6.7 3 8.0 2.7 2.4 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Phage_GP20 PF06810.11 EFO62866.1 - 4.6 7.0 10.0 0.4 10.5 4.1 2.3 2 1 0 2 2 2 0 Phage minor structural protein GP20 ATG16 PF08614.11 EFO62866.1 - 5.1 7.3 12.4 13 5.9 12.4 1.7 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) YabA PF06156.13 EFO62866.1 - 5.4 7.7 7.8 2.2 9.0 3.5 2.4 1 1 1 2 2 2 0 Initiation control protein YabA KELK PF15796.5 EFO62866.1 - 9.9 6.7 13.7 0.17 12.3 5.5 2.4 3 0 0 3 3 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase ATP-synt_D PF01813.17 EFO62867.1 - 7.6e-47 159.7 0.1 9.2e-47 159.4 0.1 1.1 1 0 0 1 1 1 1 ATP synthase subunit D DNA_repr_REX1B PF14966.6 EFO62867.1 - 0.051 14.2 0.8 0.34 11.6 0.1 2.2 2 0 0 2 2 2 0 DNA repair REX1-B NPV_P10 PF05531.12 EFO62867.1 - 0.07 13.6 0.2 5.9 7.4 0.0 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Pcc1 PF09341.10 EFO62868.1 - 3.3e-06 27.2 0.3 3.7e-06 27.0 0.3 1.1 1 0 0 1 1 1 1 Transcription factor Pcc1 Lsr2 PF11774.8 EFO62868.1 - 0.13 12.5 0.0 0.13 12.4 0.0 1.1 1 0 0 1 1 1 0 Lsr2 Aminotran_1_2 PF00155.21 EFO62869.1 - 0.08 12.1 0.0 0.097 11.8 0.0 1.1 1 0 0 1 1 1 0 Aminotransferase class I and II RRM_Rrp7 PF17799.1 EFO62873.1 - 0.035 13.9 0.2 0.077 12.8 0.2 1.5 1 0 0 1 1 1 0 Rrp7 RRM-like N-terminal domain WD40 PF00400.32 EFO62874.1 - 3.7e-15 56.0 4.5 0.00011 22.9 0.0 6.6 6 1 1 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO62874.1 - 1.6e-12 47.6 0.0 0.053 13.8 0.0 5.2 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EFO62874.1 - 0.00035 19.2 0.3 0.064 11.8 0.0 2.7 3 0 0 3 3 3 2 Cytochrome D1 heme domain PTPA PF03095.15 EFO62874.1 - 0.035 13.5 0.0 0.051 13.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotyrosyl phosphate activator (PTPA) protein Lactonase PF10282.9 EFO62874.1 - 0.043 13.1 0.2 1.2 8.4 0.1 2.4 2 1 1 3 3 3 0 Lactonase, 7-bladed beta-propeller Myosin_TH1 PF06017.13 EFO62874.1 - 0.05 13.3 0.1 0.12 12.0 0.0 1.6 2 0 0 2 2 2 0 Unconventional myosin tail, actin- and lipid-binding GMP_PDE_delta PF05351.11 EFO62875.1 - 1.5e-18 67.4 0.0 1.9e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 GMP-PDE, delta subunit AP3B1_C PF14796.6 EFO62875.1 - 0.014 15.7 0.0 0.021 15.1 0.0 1.3 1 0 0 1 1 1 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal TCR_zetazeta PF11628.8 EFO62875.1 - 0.23 11.2 1.2 3.5 7.4 0.0 2.5 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 zeta chain CAMSAP_CKK PF08683.11 EFO62876.1 - 1.4e-12 47.8 0.0 2.7e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated TMF_DNA_bd PF12329.8 EFO62876.1 - 0.0078 16.2 9.5 0.0078 16.2 9.5 3.0 3 0 0 3 3 3 1 TATA element modulatory factor 1 DNA binding HALZ PF02183.18 EFO62876.1 - 0.6 10.4 7.8 0.82 9.9 0.2 3.2 2 1 1 3 3 3 0 Homeobox associated leucine zipper Jnk-SapK_ap_N PF09744.9 EFO62876.1 - 1.5 9.0 21.4 0.26 11.5 11.6 2.9 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 Rootletin PF15035.6 EFO62876.1 - 4.5 7.3 18.6 4.5 7.3 10.0 2.8 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF1043 PF06295.12 EFO62876.1 - 8.3 6.4 17.2 0.067 13.2 6.4 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) UPF0242 PF06785.11 EFO62876.1 - 9.3 6.3 21.4 11 6.1 12.8 3.2 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus ICMT PF04140.14 EFO62877.1 - 5.2e-27 94.1 1.0 1.4e-26 92.8 0.1 1.9 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EFO62877.1 - 1.4e-08 35.0 0.5 2.6e-08 34.2 0.5 1.4 1 0 0 1 1 1 1 Phospholipid methyltransferase NnrU PF07298.11 EFO62877.1 - 0.068 12.7 1.9 0.099 12.1 0.4 1.9 1 1 1 2 2 2 0 NnrU protein Methyltransf_20 PF12147.8 EFO62877.1 - 0.12 11.5 0.0 0.16 11.1 0.0 1.1 1 0 0 1 1 1 0 Putative methyltransferase SPC25 PF06703.11 EFO62877.1 - 0.13 12.0 0.8 0.19 11.5 0.6 1.5 1 1 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) MutS_V PF00488.21 EFO62879.1 - 6.8e-58 195.8 0.1 1.2e-57 195.0 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFO62879.1 - 4.4e-17 62.9 0.1 8.7e-17 62.0 0.1 1.5 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 EFO62879.1 - 2.3e-07 31.1 0.0 6.6e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 MutS family domain IV AAA_23 PF13476.6 EFO62879.1 - 6.5e-06 26.8 1.6 1.2e-05 25.9 0.3 1.9 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFO62879.1 - 0.046 13.5 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF3060 PF11259.8 EFO62879.1 - 0.056 13.1 0.3 0.82 9.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3060) AAA_21 PF13304.6 EFO62879.1 - 0.059 13.2 0.6 0.14 12.0 0.2 1.8 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 EFO62879.1 - 0.57 10.1 2.2 2.7 7.9 0.1 2.8 3 0 0 3 3 3 0 Rad17 P-loop domain LSM PF01423.22 EFO62880.1 - 1.9e-11 43.5 0.1 2.1e-11 43.3 0.1 1.1 1 0 0 1 1 1 1 LSM domain UPF0113_N PF17833.1 EFO62881.1 - 7.1e-28 97.0 1.3 1.1e-27 96.4 1.3 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 EFO62881.1 - 1.9e-19 69.7 0.0 5.1e-19 68.3 0.0 1.7 2 1 1 3 3 3 1 UPF0113 PUA domain PUA PF01472.20 EFO62881.1 - 0.0045 16.9 0.0 0.0093 15.9 0.0 1.5 1 0 0 1 1 1 1 PUA domain Fer4 PF00037.27 EFO62883.1 - 6.6e-10 38.4 18.8 4e-05 23.2 9.0 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.6 EFO62883.1 - 2.8e-08 33.8 16.1 6.3e-08 32.6 16.1 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 EFO62883.1 - 7.2e-08 32.2 17.1 0.00069 19.6 7.3 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Nitroreductase PF00881.24 EFO62883.1 - 1.2e-07 32.0 0.0 1.8e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Nitroreductase family Fer4_9 PF13187.6 EFO62883.1 - 3e-07 30.5 14.7 5.4e-07 29.7 14.7 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EFO62883.1 - 3.5e-07 30.7 15.1 6.8e-07 29.8 15.1 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 EFO62883.1 - 3.7e-07 29.8 13.4 0.00031 20.7 3.3 2.6 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 EFO62883.1 - 2.2e-06 28.5 8.6 0.004 18.0 0.2 2.4 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 EFO62883.1 - 0.00012 22.2 15.5 0.00061 19.8 15.9 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_15 PF13459.6 EFO62883.1 - 0.0042 17.8 11.0 1.9 9.3 0.1 2.8 2 1 0 2 2 2 2 4Fe-4S single cluster domain Fer4_8 PF13183.6 EFO62883.1 - 0.0078 16.6 9.5 0.13 12.7 0.2 2.4 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_22 PF17179.4 EFO62883.1 - 0.016 16.0 8.9 0.4 11.6 0.4 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 EFO62883.1 - 0.14 12.7 20.2 0.49 11.0 4.6 3.2 3 1 1 4 4 4 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_4 PF12800.7 EFO62883.1 - 0.15 12.6 19.5 0.3 11.7 4.5 2.7 3 0 0 3 3 2 0 4Fe-4S binding domain Fer4_17 PF13534.6 EFO62883.1 - 0.22 12.1 15.0 5.3 7.7 3.3 2.5 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 EFO62883.1 - 2.4 8.4 14.3 15 5.9 14.4 2.1 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 EFO62883.1 - 9.5 7.4 23.6 10 7.3 8.3 2.8 3 0 0 3 3 2 0 4Fe-4S binding domain Peptidase_M14 PF00246.24 EFO62885.1 - 3.4e-17 63.2 0.1 1.5e-16 61.1 0.1 1.9 1 1 0 1 1 1 1 Zinc carboxypeptidase Pepdidase_M14_N PF18027.1 EFO62885.1 - 2.2e-06 27.9 0.1 4.4e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain AstE_AspA PF04952.14 EFO62885.1 - 0.00011 21.4 0.1 0.00071 18.7 0.0 2.0 2 0 0 2 2 2 1 Succinylglutamate desuccinylase / Aspartoacylase family Alginate_lyase PF05426.12 EFO62886.1 - 0.098 12.2 1.5 0.098 12.2 1.5 1.1 1 0 0 1 1 1 0 Alginate lyase Ank_2 PF12796.7 EFO62888.1 - 2.7e-34 117.6 2.7 6.1e-10 39.6 0.3 4.8 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62888.1 - 3.4e-33 113.2 7.1 3.1e-09 36.9 0.2 7.4 4 2 4 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62888.1 - 1.6e-32 107.9 7.3 5.3e-06 26.4 0.0 8.2 8 0 0 8 8 8 7 Ankyrin repeat Ank_4 PF13637.6 EFO62888.1 - 6.2e-31 106.4 7.8 8e-06 26.3 0.1 7.7 3 3 5 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO62888.1 - 7e-24 83.2 7.9 0.00012 22.4 0.0 7.7 8 0 0 8 8 8 6 Ankyrin repeat Peptidase_S37 PF05576.11 EFO62889.1 - 0.092 11.4 0.2 0.15 10.7 0.2 1.2 1 0 0 1 1 1 0 PS-10 peptidase S37 UL41A PF17591.2 EFO62890.1 - 0.11 12.6 0.5 0.19 11.8 0.5 1.3 1 0 0 1 1 1 0 Herpesvirus UL41A NB PF04159.13 EFO62890.1 - 0.18 11.9 0.2 1 9.5 0.0 2.0 1 1 1 2 2 2 0 NB glycoprotein FWWh PF14922.6 EFO62892.1 - 3.2e-07 30.4 0.1 5.8e-05 23.1 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function Fer4_20 PF14691.6 EFO62893.1 - 1.5e-40 137.5 4.0 3.3e-40 136.4 4.0 1.6 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.14 EFO62893.1 - 5.7e-33 114.4 0.4 8.2e-33 113.9 0.4 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFO62893.1 - 2e-13 50.3 0.4 2.9e-09 36.6 0.0 3.2 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFO62893.1 - 5.5e-11 42.9 0.0 5.1e-06 27.0 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFO62893.1 - 5.5e-08 32.9 0.6 1.1e-06 28.8 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFO62893.1 - 6.9e-07 28.7 2.6 0.0027 16.9 0.2 3.1 3 0 0 3 3 3 2 FAD binding domain AlaDh_PNT_C PF01262.21 EFO62893.1 - 1.5e-06 27.7 0.1 0.0014 18.0 0.0 2.4 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EFO62893.1 - 7.4e-06 24.9 1.2 0.00074 18.3 0.1 2.6 2 0 0 2 2 2 1 HI0933-like protein 2-Hacid_dh_C PF02826.19 EFO62893.1 - 4.8e-05 22.8 0.0 0.11 11.9 0.0 2.4 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EFO62893.1 - 6.9e-05 23.2 0.8 0.019 15.4 0.1 2.8 2 0 0 2 2 2 1 Putative NAD(P)-binding DAO PF01266.24 EFO62893.1 - 0.00011 22.0 1.0 0.00037 20.2 0.2 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase PALP PF00291.25 EFO62893.1 - 0.00011 21.8 0.0 0.017 14.5 0.0 2.2 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme FAD_oxidored PF12831.7 EFO62893.1 - 0.00022 20.7 2.2 0.026 13.9 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFO62893.1 - 0.0027 17.0 0.4 0.0087 15.3 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain F420_oxidored PF03807.17 EFO62893.1 - 0.0042 17.6 0.1 3.9 8.1 0.0 2.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent FMO-like PF00743.19 EFO62893.1 - 0.005 15.3 0.1 2.1 6.7 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like 3HCDH_N PF02737.18 EFO62893.1 - 0.0063 16.4 0.1 1 9.2 0.0 2.4 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 EFO62893.1 - 0.0083 16.2 1.7 0.19 11.8 0.1 2.8 3 0 0 3 3 3 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain XdhC_C PF13478.6 EFO62893.1 - 0.01 16.3 0.1 0.2 12.2 0.0 2.4 2 0 0 2 2 2 0 XdhC Rossmann domain Thi4 PF01946.17 EFO62893.1 - 0.011 15.0 0.3 0.029 13.6 0.1 1.7 2 0 0 2 2 2 0 Thi4 family IlvN PF07991.12 EFO62893.1 - 0.017 14.7 0.0 1.6 8.3 0.0 2.5 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Amino_oxidase PF01593.24 EFO62893.1 - 0.049 12.9 0.1 0.076 12.3 0.1 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase GIDA PF01134.22 EFO62893.1 - 0.059 12.4 2.4 4.5 6.2 0.1 3.0 3 0 0 3 3 3 0 Glucose inhibited division protein A Fer4_6 PF12837.7 EFO62893.1 - 0.11 12.6 2.8 0.48 10.6 2.8 2.1 1 0 0 1 1 1 0 4Fe-4S binding domain Mito_fiss_Elm1 PF06258.11 EFO62893.1 - 0.12 11.5 0.0 0.86 8.7 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial fission ELM1 EGF_CA PF07645.15 EFO62893.1 - 0.16 12.2 4.1 0.6 10.4 4.1 2.0 1 0 0 1 1 1 0 Calcium-binding EGF domain VSP PF03302.13 EFO62894.1 - 2.1e-24 86.1 84.0 2.3e-19 69.6 53.9 3.6 1 1 2 3 3 3 3 Giardia variant-specific surface protein VSP PF03302.13 EFO62895.1 - 2.3e-31 109.0 184.1 6.8e-21 74.6 72.1 7.3 1 1 4 5 5 5 5 Giardia variant-specific surface protein DUF4705 PF15788.5 EFO62895.1 - 0.31 11.3 3.6 0.88 9.9 3.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4705) VSP PF03302.13 EFO62896.1 - 1.6e-92 310.4 103.3 9.7e-52 176.1 26.8 4.0 1 1 3 4 4 4 4 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO62896.1 - 0.0095 16.1 2.0 0.025 14.7 0.2 2.2 2 0 0 2 2 2 1 Podoplanin zf-C2H2 PF00096.26 EFO62898.1 - 0.014 15.8 0.0 0.026 15.0 0.0 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_9 PF16293.5 EFO62898.1 - 0.047 13.5 0.1 0.08 12.8 0.1 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) zf-C2H2_4 PF13894.6 EFO62898.1 - 0.065 14.1 0.0 0.15 13.0 0.0 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger Nop14 PF04147.12 EFO62899.1 - 8.4e-15 54.1 11.5 3.5e-07 28.9 0.1 3.2 2 1 0 3 3 3 3 Nop14-like family DUF4047 PF13256.6 EFO62899.1 - 9.1 6.5 6.4 3.8 7.7 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) DUF5045 PF16464.5 EFO62900.1 - 0.048 14.0 0.0 0.15 12.4 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5045) Motile_Sperm PF00635.26 EFO62901.1 - 0.00039 20.2 0.0 0.00067 19.5 0.0 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain MYO10_CC PF16735.5 EFO62901.1 - 0.023 14.8 1.0 0.047 13.8 1.0 1.5 1 0 0 1 1 1 0 Unconventional myosin-X coiled coil domain IL17R_fnIII_D1 PF16556.5 EFO62901.1 - 0.11 12.2 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Interleukin-17 receptor, fibronectin-III-like domain 1 SlyX PF04102.12 EFO62901.1 - 0.13 12.9 0.9 0.26 11.9 0.9 1.4 1 0 0 1 1 1 0 SlyX UPF0029 PF01205.19 EFO62902.1 - 1.5e-28 99.2 0.0 2.4e-28 98.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 LCAT PF02450.15 EFO62903.1 - 9.5e-15 54.6 0.2 2.6e-14 53.2 0.0 1.7 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 EFO62903.1 - 0.00036 19.9 0.0 0.0007 18.9 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Lipase_2 PF01674.18 EFO62903.1 - 0.00037 20.1 0.0 0.00075 19.1 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 2) Abhydrolase_1 PF00561.20 EFO62903.1 - 0.0006 19.5 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.13 EFO62903.1 - 0.0007 19.4 0.0 0.0027 17.5 0.0 1.8 2 0 0 2 2 2 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EFO62903.1 - 0.00071 20.2 0.0 0.0017 19.0 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 EFO62903.1 - 0.0013 18.6 0.0 0.0022 17.9 0.0 1.4 1 0 0 1 1 1 1 Palmitoyl protein thioesterase tRNA-synt_2b PF00587.25 EFO62904.1 - 5.5e-44 150.3 0.0 1.1e-43 149.2 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFO62904.1 - 1.6e-11 44.2 0.2 3.3e-11 43.2 0.2 1.5 1 0 0 1 1 1 1 Anticodon binding domain ProRS-C_1 PF09180.11 EFO62904.1 - 1.9e-08 34.4 2.2 2.8e-08 33.8 0.3 2.3 2 0 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal SecY PF00344.20 EFO62905.1 - 1.1e-52 179.3 15.0 1.4e-52 178.8 15.0 1.2 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EFO62905.1 - 2.1e-12 46.7 1.9 3.1e-12 46.1 0.1 2.4 2 0 0 2 2 2 1 Plug domain of Sec61p Proton_antipo_N PF00662.20 EFO62905.1 - 0.0048 16.9 0.1 0.022 14.8 0.1 2.2 1 0 0 1 1 1 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus SHR3_chaperone PF08229.11 EFO62905.1 - 0.28 10.2 5.7 1.2 8.0 0.1 2.9 3 0 0 3 3 3 0 ER membrane protein SH3 VSP PF03302.13 EFO62908.1 - 6.1e-18 64.9 177.3 2.7e-06 26.5 19.8 8.4 1 1 6 7 7 7 6 Giardia variant-specific surface protein DUF4690 PF15756.5 EFO62908.1 - 0.45 11.2 1.6 1.4 9.6 1.6 1.8 1 0 0 1 1 1 0 Small Novel Rich in Cartilage START PF01852.19 EFO62909.1 - 4.9e-05 22.8 0.0 9.1e-05 22.0 0.0 1.4 1 1 0 1 1 1 1 START domain EF-hand_11 PF08976.11 EFO62910.1 - 0.2 12.5 0.9 2.3 9.1 0.2 2.7 3 0 0 3 3 3 0 EF-hand domain PHD PF00628.29 EFO62911.1 - 0.0013 18.5 7.3 0.0013 18.5 7.3 4.5 3 2 0 3 3 3 1 PHD-finger TM2 PF05154.16 EFO62912.1 - 7.2e-16 58.3 10.8 9.2e-16 57.9 10.8 1.2 1 0 0 1 1 1 1 TM2 domain VSP PF03302.13 EFO62913.1 - 0.5 9.2 67.9 0.075 11.9 10.4 5.0 2 1 2 4 4 4 0 Giardia variant-specific surface protein Glug PF07581.12 EFO62913.1 - 5.6 7.6 45.0 4.2 8.0 0.1 11.4 12 1 1 13 13 13 0 The GLUG motif HlyD_2 PF12700.7 EFO62914.1 - 0.043 12.5 4.1 0.073 11.8 4.1 1.2 1 0 0 1 1 1 0 HlyD family secretion protein ApoO PF09769.9 EFO62914.1 - 0.061 13.3 0.5 0.19 11.7 0.5 1.8 1 0 0 1 1 1 0 Apolipoprotein O DivIC PF04977.15 EFO62914.1 - 1.3 8.8 6.3 3.8 7.4 6.3 1.7 1 0 0 1 1 1 0 Septum formation initiator TMF_DNA_bd PF12329.8 EFO62914.1 - 2.3 8.3 17.8 0.19 11.8 10.6 2.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Ank_2 PF12796.7 EFO62915.1 - 3.8e-43 145.9 1.3 1.4e-14 54.4 0.1 3.6 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62915.1 - 6.1e-34 116.0 11.3 6.9e-09 36.1 0.5 5.7 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62915.1 - 1.1e-28 99.0 8.1 3.4e-06 27.2 0.0 8.1 2 1 6 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62915.1 - 2.8e-26 88.7 2.5 0.0053 17.2 0.1 7.6 7 0 0 7 7 7 6 Ankyrin repeat Ank PF00023.30 EFO62915.1 - 1.5e-23 82.1 2.6 0.00075 19.8 0.0 7.5 6 1 1 7 7 7 4 Ankyrin repeat Pkinase PF00069.25 EFO62915.1 - 9.3e-23 80.9 0.0 2e-22 79.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62915.1 - 9.9e-13 48.0 0.0 2.4e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFO62915.1 - 0.0043 17.0 0.0 0.01 15.8 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family VSP PF03302.13 EFO62916.1 - 6.9e-11 41.6 108.6 0.018 13.9 64.3 5.0 1 1 2 3 3 3 3 Giardia variant-specific surface protein NICE-3 PF07406.11 EFO62916.1 - 0.24 11.4 0.7 0.33 10.9 0.7 1.2 1 0 0 1 1 1 0 NICE-3 protein Ank_2 PF12796.7 EFO62917.1 - 9.1e-60 199.2 26.0 3.2e-13 50.1 0.1 8.6 2 2 8 11 11 11 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62917.1 - 7.7e-32 109.3 13.1 1.3e-06 28.8 0.0 11.6 9 6 5 14 14 14 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62917.1 - 8e-27 90.3 17.8 0.029 14.9 0.0 14.7 15 0 0 15 15 15 6 Ankyrin repeat Ank_5 PF13857.6 EFO62917.1 - 1e-26 92.6 15.1 8.9e-05 22.7 0.0 11.7 8 3 5 13 13 13 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO62917.1 - 2e-25 88.1 19.7 0.0019 18.6 0.0 12.7 13 1 0 13 13 13 7 Ankyrin repeat F_bP_aldolase PF01116.20 EFO62917.1 - 0.067 12.7 0.5 0.17 11.4 0.4 1.6 2 0 0 2 2 2 0 Fructose-bisphosphate aldolase class-II Maf PF02545.14 EFO62918.1 - 2.1e-38 131.8 0.0 2.4e-38 131.6 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein RIBIOP_C PF04950.12 EFO62919.1 - 3.1e-45 154.9 0.0 7.9e-45 153.5 0.0 1.7 1 1 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal Pkinase PF00069.25 EFO62920.1 - 6.4e-25 88.0 1.6 2.6e-10 40.1 0.5 4.2 4 0 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62920.1 - 2e-15 56.8 0.0 1e-12 47.9 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase SNF2_N PF00176.23 EFO62921.1 - 3.8e-44 150.8 1.1 3.8e-44 150.8 1.1 1.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFO62921.1 - 7.8e-24 84.2 0.2 3.4e-23 82.1 0.2 2.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EFO62921.1 - 9.2e-14 51.3 2.0 2.9e-13 49.6 2.0 1.8 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Chromo PF00385.24 EFO62921.1 - 6.4e-08 32.4 2.7 0.0035 17.2 0.0 3.2 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 EFO62921.1 - 6.4e-07 29.5 0.1 6.4e-06 26.3 0.0 2.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA PF00004.29 EFO62923.1 - 1.2e-14 54.9 0.2 3.1e-14 53.5 0.1 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EFO62923.1 - 1e-08 35.1 0.3 2e-06 27.7 0.0 2.6 2 1 1 3 3 3 1 DNA polymerase III, delta subunit DNA_pol3_delta PF06144.13 EFO62923.1 - 1.5e-07 31.4 0.1 2.3e-07 30.7 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit RuvB_N PF05496.12 EFO62923.1 - 3.5e-07 30.1 0.5 1.9e-06 27.7 0.1 2.3 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EFO62923.1 - 5.9e-07 29.6 0.0 9.7e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain Rep_fac_C PF08542.11 EFO62923.1 - 6.3e-07 29.7 0.0 1.7e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA_22 PF13401.6 EFO62923.1 - 1.5e-05 25.3 1.1 0.011 15.9 0.3 3.5 1 1 2 3 3 3 1 AAA domain AAA_16 PF13191.6 EFO62923.1 - 1.7e-05 25.2 0.3 0.0021 18.5 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 EFO62923.1 - 4.5e-05 23.3 0.0 0.0001 22.1 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_assoc_2 PF16193.5 EFO62923.1 - 0.00011 22.4 0.1 0.00028 21.1 0.1 1.7 1 0 0 1 1 1 1 AAA C-terminal domain AAA_5 PF07728.14 EFO62923.1 - 0.0003 20.8 0.1 0.0017 18.3 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 EFO62923.1 - 0.00056 20.3 1.8 0.014 15.7 0.3 2.3 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 EFO62923.1 - 0.00069 19.4 0.1 0.0064 16.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EFO62923.1 - 0.00089 18.7 0.4 0.034 13.5 0.1 2.3 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EFO62923.1 - 0.0034 17.9 0.2 0.045 14.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain DnaB_C PF03796.15 EFO62923.1 - 0.0037 16.6 0.0 0.0059 16.0 0.0 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain DUF815 PF05673.13 EFO62923.1 - 0.0065 15.7 0.0 0.015 14.5 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 EFO62923.1 - 0.0066 16.2 0.5 0.41 10.3 0.1 2.8 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_25 PF13481.6 EFO62923.1 - 0.0072 15.9 0.0 0.036 13.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EFO62923.1 - 0.0079 15.4 0.1 0.029 13.6 0.0 1.8 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_3 PF07726.11 EFO62923.1 - 0.018 14.9 0.1 0.045 13.6 0.0 1.7 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.6 EFO62923.1 - 0.019 15.1 0.4 0.17 12.0 0.1 2.4 2 1 0 2 2 2 0 Sigma-54 interaction domain Viral_helicase1 PF01443.18 EFO62923.1 - 0.022 14.5 0.0 0.045 13.5 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.27 EFO62923.1 - 0.025 15.1 0.0 0.051 14.1 0.0 1.7 1 1 0 1 1 1 0 ABC transporter CLP1_P PF16575.5 EFO62923.1 - 0.027 14.3 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_28 PF13521.6 EFO62923.1 - 0.028 14.7 0.0 0.055 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain CobA_CobO_BtuR PF02572.15 EFO62923.1 - 0.032 14.5 0.0 0.087 13.1 0.0 1.7 2 0 0 2 2 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP NTPase_1 PF03266.15 EFO62923.1 - 0.039 13.9 3.0 0.16 11.9 0.2 2.8 2 1 1 3 3 3 0 NTPase AAA_7 PF12775.7 EFO62923.1 - 0.04 13.4 0.0 0.11 12.1 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region KTI12 PF08433.10 EFO62923.1 - 0.071 12.5 0.3 0.55 9.6 0.0 2.3 1 1 2 3 3 3 0 Chromatin associated protein KTI12 AAA_26 PF13500.6 EFO62923.1 - 0.085 12.7 0.0 0.54 10.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EFO62923.1 - 0.1 11.6 0.0 0.24 10.4 0.0 1.6 2 0 0 2 2 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SR-25 PF10500.9 EFO62923.1 - 0.16 11.6 0.0 0.26 10.9 0.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TniB PF05621.11 EFO62923.1 - 0.17 11.3 0.7 2.8 7.3 0.0 2.7 3 0 0 3 3 3 0 Bacterial TniB protein DUF4359 PF14271.6 EFO62923.1 - 0.29 11.9 1.7 1.3 9.8 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4359) SapB_1 PF05184.15 EFO62923.1 - 0.33 11.0 2.1 0.69 10.0 0.0 2.7 3 0 0 3 3 3 0 Saposin-like type B, region 1 Ank_2 PF12796.7 EFO62924.1 - 5.6e-30 103.8 4.9 1.2e-13 51.5 0.9 2.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62924.1 - 2.8e-16 59.3 2.5 9.6e-07 29.0 0.0 3.7 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO62924.1 - 1.1e-14 54.1 0.6 0.00012 22.4 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 EFO62924.1 - 3.7e-12 46.5 1.2 2.2e-05 24.9 0.2 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62924.1 - 5.8e-09 35.5 4.4 0.018 15.5 0.1 3.8 4 0 0 4 4 4 3 Ankyrin repeat PK_C PF02887.16 EFO62924.1 - 0.16 12.2 0.0 2.6 8.3 0.0 2.5 1 1 0 1 1 1 0 Pyruvate kinase, alpha/beta domain AP3B1_C PF14796.6 EFO62925.1 - 0.024 14.9 1.0 0.058 13.7 0.2 2.1 2 0 0 2 2 2 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal YcgR_2 PF12945.7 EFO62926.1 - 0.053 13.7 0.1 0.46 10.7 0.1 2.4 2 0 0 2 2 2 0 Flagellar protein YcgR zf-C2H2 PF00096.26 EFO62927.1 - 8.2e-06 26.0 6.9 7.8e-05 22.9 0.3 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFO62927.1 - 3.5e-05 24.3 7.3 0.0042 17.8 0.3 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFO62927.1 - 0.017 15.4 0.1 0.47 10.8 0.0 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 EFO62927.1 - 0.035 13.7 0.9 0.46 10.2 0.2 2.2 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain CK_II_beta PF01214.18 EFO62928.1 - 1.3e-38 132.7 0.0 1.6e-38 132.3 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit EF-hand_7 PF13499.6 EFO62929.1 - 1.1e-08 35.4 2.3 9.9e-05 22.7 0.0 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EFO62929.1 - 3.9e-06 26.3 1.1 0.0079 16.0 0.1 4.0 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 EFO62929.1 - 6.4e-06 25.9 0.1 0.00031 20.5 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EFO62929.1 - 3.5e-05 23.1 0.1 0.00043 19.6 0.1 2.8 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 EFO62929.1 - 0.00022 20.6 0.0 0.00082 18.8 0.0 2.0 1 0 0 1 1 1 1 EF hand zf-C2H2_2 PF12756.7 EFO62938.1 - 3e-24 85.3 14.3 5.7e-20 71.5 2.5 3.3 2 1 1 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EFO62938.1 - 6.8e-11 42.2 16.3 1.3e-07 31.7 3.1 3.9 4 0 0 4 4 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EFO62938.1 - 1e-06 29.0 13.1 0.014 16.2 0.2 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.7 EFO62938.1 - 1.5e-06 28.4 1.9 1.5e-06 28.4 1.9 3.4 3 0 0 3 3 3 1 Zinc-finger of C2H2 type DUF2757 PF10955.8 EFO62938.1 - 0.0023 18.2 1.5 0.0042 17.3 0.0 2.3 2 2 0 2 2 2 1 Protein of unknown function (DUF2757) zf-3CxxC_2 PF17180.4 EFO62938.1 - 0.078 13.7 0.1 0.078 13.7 0.1 2.5 3 0 0 3 3 3 0 Zinc-binding domain zf-C2H2 PF00096.26 EFO62938.1 - 0.091 13.3 0.6 0.091 13.3 0.6 4.5 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_9 PF16293.5 EFO62938.1 - 0.22 11.4 3.7 22 5.0 0.0 3.6 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-LYAR PF08790.11 EFO62938.1 - 0.26 11.2 8.8 1.5 8.7 0.2 3.5 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-U1 PF06220.12 EFO62938.1 - 0.66 9.8 3.4 1 9.2 0.3 2.6 2 0 0 2 2 2 0 U1 zinc finger zf-C2H2_6 PF13912.6 EFO62938.1 - 2 8.5 12.5 0.59 10.2 1.5 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger AKAP95 PF04988.12 EFO62938.1 - 3.7 7.8 6.5 2.6 8.2 1.7 2.5 1 1 1 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_11 PF16622.5 EFO62938.1 - 4.3 7.2 5.5 8.8 6.2 0.1 3.1 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-H2C2_2 PF13465.6 EFO62938.1 - 7.6 7.2 9.3 12 6.5 0.1 4.0 4 0 0 4 4 4 0 Zinc-finger double domain Tctex-1 PF03645.13 EFO62940.1 - 1.2e-19 70.5 0.3 1.4e-19 70.2 0.3 1.1 1 0 0 1 1 1 1 Tctex-1 family RsgA_GTPase PF03193.16 EFO62942.1 - 0.0075 16.2 2.8 0.084 12.8 0.1 2.7 2 0 0 2 2 2 2 RsgA GTPase LepB_N PF18640.1 EFO62943.1 - 0.099 12.3 0.0 0.26 10.9 0.0 1.6 1 0 0 1 1 1 0 LepB N-terminal domain Vps51 PF08700.11 EFO62944.1 - 0.058 13.5 4.3 0.068 13.3 1.1 3.0 2 0 0 2 2 2 0 Vps51/Vps67 MPS2 PF17060.5 EFO62944.1 - 0.14 11.4 7.3 0.37 10.0 7.3 1.7 1 0 0 1 1 1 0 Monopolar spindle protein 2 FUSC PF04632.12 EFO62944.1 - 0.73 8.3 2.4 1.3 7.4 2.4 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family ATP-synt_D PF01813.17 EFO62944.1 - 1.2 8.9 16.5 0.31 10.9 3.4 4.0 5 0 0 5 5 5 0 ATP synthase subunit D Sec34 PF04136.15 EFO62944.1 - 1.3 8.9 10.7 1.3 8.9 4.6 3.0 2 0 0 2 2 2 0 Sec34-like family TSC22 PF01166.18 EFO62944.1 - 3.2 8.2 11.5 0.2 12.0 0.2 3.6 3 0 0 3 3 3 0 TSC-22/dip/bun family Occludin_ELL PF07303.13 EFO62944.1 - 3.5 8.4 8.7 1.2 9.9 3.6 3.0 2 0 0 2 2 2 0 Occludin homology domain DUF2935 PF11155.8 EFO62944.1 - 3.5 8.0 15.5 33 4.8 8.4 4.3 2 1 1 3 3 3 0 Domain of unknown function (DUF2935) SlyX PF04102.12 EFO62944.1 - 5.9 7.6 25.7 0.73 10.5 5.8 4.8 2 1 2 4 4 4 0 SlyX DUF1664 PF07889.12 EFO62944.1 - 7.7 6.6 8.6 1.5 8.9 2.8 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) ATP-synt_C PF00137.21 EFO62945.1 - 4.2e-23 81.5 24.7 1.2e-12 47.9 6.5 2.1 2 0 0 2 2 2 2 ATP synthase subunit C TMEM208_SND2 PF05620.11 EFO62947.1 - 8.5e-28 97.2 0.1 1e-27 96.9 0.1 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 7TMR-DISM_7TM PF07695.11 EFO62947.1 - 0.87 9.4 7.9 6.3 6.6 0.1 2.0 2 0 0 2 2 2 0 7TM diverse intracellular signalling Methyltransf_PK PF05891.12 EFO62948.1 - 4.5e-42 144.0 0.0 5.7e-42 143.7 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 EFO62948.1 - 0.0001 23.0 0.1 0.00017 22.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFO62948.1 - 0.00011 22.9 0.0 0.0002 22.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFO62948.1 - 0.00028 20.8 0.0 0.00084 19.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFO62948.1 - 0.0014 19.3 0.0 0.0023 18.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFO62948.1 - 0.0055 16.5 0.0 0.0092 15.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain ATP-synt_ab PF00006.25 EFO62949.1 - 1.6e-57 194.6 0.0 2.9e-57 193.8 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EFO62949.1 - 9.1e-11 42.1 0.5 1.6e-10 41.3 0.5 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Spc42p PF11544.8 EFO62950.1 - 0.087 12.8 7.4 1.2 9.2 0.3 4.4 3 0 0 3 3 3 0 Spindle pole body component Spc42p FlxA PF14282.6 EFO62951.1 - 1.1 9.3 4.4 2.2 8.3 4.4 1.5 1 0 0 1 1 1 0 FlxA-like protein HAD_2 PF13419.6 EFO62953.1 - 1.4e-25 90.4 0.0 1.6e-25 90.2 0.0 1.0 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFO62953.1 - 8e-11 42.6 0.1 2.8e-08 34.3 0.1 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFO62953.1 - 1.5e-06 28.1 0.0 3.6e-06 27.0 0.0 1.6 2 0 0 2 2 2 1 HAD-hyrolase-like HAD PF12710.7 EFO62953.1 - 0.0012 19.2 0.0 0.0017 18.8 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.14 EFO62953.1 - 0.051 13.2 0.1 0.082 12.5 0.1 1.4 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Hydrolase_3 PF08282.12 EFO62953.1 - 0.11 12.3 0.1 0.5 10.1 0.1 1.9 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Pkinase PF00069.25 EFO62954.1 - 7.3e-32 110.8 0.0 1.1e-31 110.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO62954.1 - 8.3e-17 61.3 0.0 8.6e-16 58.0 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO62954.1 - 0.022 14.1 0.0 0.13 11.6 0.0 2.0 2 0 0 2 2 2 0 Kinase-like PAR1 PF06521.11 EFO62954.1 - 0.19 11.4 0.1 0.44 10.2 0.1 1.6 1 0 0 1 1 1 0 PAR1 protein RTT107_BRCT_5 PF16770.5 EFO62955.1 - 0.58 10.1 6.6 0.16 11.8 1.3 2.7 2 2 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain Str_synth PF03088.16 EFO62956.1 - 0.056 13.6 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Strictosidine synthase DUF1375 PF07119.12 EFO62960.1 - 0.033 14.6 0.0 0.096 13.1 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1375) NHL PF01436.21 EFO62960.1 - 0.049 13.7 0.1 1 9.6 0.0 3.3 4 1 0 4 4 4 0 NHL repeat Vps54_N PF10475.9 EFO62961.1 - 0.038 13.3 0.4 0.074 12.3 0.3 1.5 1 1 1 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex Mito_fiss_reg PF05308.11 EFO62961.1 - 0.052 13.6 0.2 0.058 13.5 0.2 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator DUF1664 PF07889.12 EFO62962.1 - 0.0019 18.2 3.8 0.0019 18.2 3.8 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 EFO62962.1 - 0.019 15.0 8.9 0.2 11.7 7.8 2.5 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus SHE3 PF17078.5 EFO62962.1 - 0.02 14.6 20.5 0.047 13.4 20.5 1.6 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 AAA_13 PF13166.6 EFO62962.1 - 0.031 12.9 15.8 0.039 12.6 15.8 1.1 1 0 0 1 1 1 0 AAA domain CENP-K PF11802.8 EFO62962.1 - 0.039 13.5 17.5 0.053 13.1 17.5 1.2 1 0 0 1 1 1 0 Centromere-associated protein K WXG100 PF06013.12 EFO62962.1 - 0.044 14.0 9.3 0.49 10.7 1.2 3.8 2 1 2 4 4 4 0 Proteins of 100 residues with WXG MCPsignal PF00015.21 EFO62962.1 - 0.11 12.3 3.0 0.053 13.3 0.6 1.8 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain NPV_P10 PF05531.12 EFO62962.1 - 0.19 12.2 9.0 0.3 11.6 0.2 3.2 1 1 3 4 4 4 0 Nucleopolyhedrovirus P10 protein CHDCT2 PF08074.11 EFO62962.1 - 0.29 11.3 9.0 0.12 12.6 6.0 1.7 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain Exonuc_VII_L PF02601.15 EFO62962.1 - 0.38 10.3 14.4 1 8.9 14.4 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit UPF0242 PF06785.11 EFO62962.1 - 0.46 10.6 25.7 1.4 9.0 14.1 2.3 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Syntaxin-6_N PF09177.11 EFO62962.1 - 0.51 10.9 10.4 0.05 14.2 4.0 2.4 2 1 1 3 3 3 0 Syntaxin 6, N-terminal Occludin_ELL PF07303.13 EFO62962.1 - 1.3 9.7 14.7 2.6 8.8 1.1 3.4 1 1 0 2 2 2 0 Occludin homology domain DUF2203 PF09969.9 EFO62962.1 - 1.8 9.3 10.3 0.24 12.2 1.1 2.7 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF4407 PF14362.6 EFO62962.1 - 2 7.7 13.6 13 5.0 13.6 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF45 PF01863.17 EFO62962.1 - 2.2 8.2 9.6 2.1 8.3 6.5 2.0 1 1 1 2 2 2 0 Protein of unknown function DUF45 Allexi_40kDa PF05549.11 EFO62962.1 - 4 6.9 11.9 3.1 7.2 1.7 2.1 1 1 1 2 2 2 0 Allexivirus 40kDa protein DUF948 PF06103.11 EFO62962.1 - 4.7 7.5 6.9 89 3.4 6.8 2.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.10 EFO62962.1 - 7.4 6.7 16.1 0.28 11.4 6.9 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family TRM PF02005.16 EFO62963.1 - 7e-87 292.0 0.0 9.1e-87 291.7 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase TBPIP PF07106.13 EFO62963.1 - 0.014 15.3 0.0 2 8.4 0.0 2.4 2 0 0 2 2 2 0 TBPIP/Hop2 winged helix domain UIM PF02809.20 EFO62964.1 - 10 6.3 12.1 5.1 7.2 8.2 2.7 2 1 0 2 2 2 0 Ubiquitin interaction motif Ank_2 PF12796.7 EFO62966.1 - 3.1e-56 187.9 8.2 3.3e-16 59.6 0.1 4.1 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO62966.1 - 3.7e-32 111.8 0.0 9.9e-32 110.3 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Ank_5 PF13857.6 EFO62966.1 - 1.6e-24 85.6 0.3 1.6e-06 28.3 0.0 6.1 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62966.1 - 3.2e-23 81.8 0.0 5.1e-08 33.3 0.0 6.0 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62966.1 - 6.5e-21 72.2 0.1 0.0098 16.3 0.0 7.0 7 0 0 7 7 6 5 Ankyrin repeat Pkinase_Tyr PF07714.17 EFO62966.1 - 2.7e-20 72.8 0.0 6.3e-20 71.5 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Ank PF00023.30 EFO62966.1 - 2.5e-17 62.4 0.0 0.024 15.1 0.0 7.1 7 0 0 7 7 7 4 Ankyrin repeat TMF_DNA_bd PF12329.8 EFO62966.1 - 0.019 15.0 4.4 0.055 13.5 4.4 1.7 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding HTH_Tnp_Tc5 PF03221.16 EFO62966.1 - 0.044 13.8 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain Choline_kinase PF01633.20 EFO62966.1 - 0.083 12.5 0.2 0.23 11.0 0.0 1.8 2 1 0 2 2 2 0 Choline/ethanolamine kinase SlyX PF04102.12 EFO62966.1 - 0.1 13.2 0.1 0.25 12.0 0.1 1.6 1 0 0 1 1 1 0 SlyX APH PF01636.23 EFO62966.1 - 0.17 11.8 0.0 0.36 10.7 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Resolvase PF00239.21 EFO62966.1 - 3.5 7.7 6.2 8.5 6.5 0.6 3.0 1 1 0 2 2 2 0 Resolvase, N terminal domain Tctex-1 PF03645.13 EFO62967.1 - 1.3e-19 70.3 0.2 1.4e-19 70.2 0.2 1.0 1 0 0 1 1 1 1 Tctex-1 family Ank_2 PF12796.7 EFO62968.1 - 1.9e-33 114.9 4.6 2.5e-11 44.0 0.1 4.9 2 2 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62968.1 - 5.3e-25 87.1 9.8 0.0004 20.6 0.0 7.9 2 2 6 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62968.1 - 2.4e-18 64.3 9.1 0.049 14.2 0.0 7.9 8 0 0 8 8 8 6 Ankyrin repeat Ank_4 PF13637.6 EFO62968.1 - 1.2e-17 64.0 1.8 0.015 15.9 0.0 6.5 6 0 0 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO62968.1 - 7.1e-17 61.0 6.3 0.019 15.4 0.0 7.3 7 0 0 7 7 7 5 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO62969.1 - 2.1e-12 46.7 12.6 5.2e-12 45.4 12.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Ank_2 PF12796.7 EFO62969.1 - 1e-10 42.1 1.2 3e-06 27.7 0.1 4.2 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Prok-RING_4 PF14447.6 EFO62969.1 - 8.3e-09 35.2 12.3 1.9e-08 34.0 12.3 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFO62969.1 - 6.3e-07 29.6 12.6 1.6e-06 28.3 12.6 1.8 1 0 0 1 1 1 1 Ring finger domain Ank_5 PF13857.6 EFO62969.1 - 3.1e-06 27.3 0.4 0.17 12.3 0.0 4.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO62969.1 - 1.3e-05 25.4 5.1 0.83 10.2 0.0 6.4 7 0 0 7 7 6 2 Ankyrin repeat Ank_3 PF13606.6 EFO62969.1 - 1.5e-05 25.0 5.3 2.5 9.0 0.0 6.0 6 0 0 6 6 5 2 Ankyrin repeat zf-C3HC4_2 PF13923.6 EFO62969.1 - 0.00018 21.2 14.7 0.00033 20.4 13.7 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Ank_4 PF13637.6 EFO62969.1 - 0.0002 21.9 0.7 3 8.5 0.0 6.2 3 1 3 6 6 6 1 Ankyrin repeats (many copies) zf-RING_5 PF14634.6 EFO62969.1 - 0.00051 19.9 14.1 0.00051 19.9 14.1 1.8 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFO62969.1 - 0.66 10.0 8.7 1.9 8.6 8.7 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.7 EFO62969.1 - 1.1 9.6 7.4 2.8 8.3 7.4 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain Ank_2 PF12796.7 EFO62970.1 - 6.1e-105 344.0 33.3 9e-19 67.9 0.1 9.1 1 1 8 10 10 10 10 Ankyrin repeats (3 copies) Ank PF00023.30 EFO62970.1 - 1.6e-55 183.2 27.9 0.002 18.5 0.0 17.5 17 1 1 18 18 18 15 Ankyrin repeat Ank_4 PF13637.6 EFO62970.1 - 5.2e-54 180.0 22.9 1e-10 41.9 0.1 13.6 6 4 6 14 14 14 11 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO62970.1 - 1.1e-53 178.6 36.8 1.1e-06 28.8 0.0 15.2 4 4 11 16 16 16 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62970.1 - 2.2e-47 153.5 23.1 0.0027 18.0 0.0 16.8 18 0 0 18 18 18 11 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO62970.1 - 7.4e-09 35.3 19.8 7.4e-09 35.3 19.8 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) 3HCDH_RFF PF18321.1 EFO62970.1 - 0.032 14.7 5.3 9.7 6.7 0.0 5.2 5 0 0 5 5 5 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain Y_phosphatase3 PF13350.6 EFO62970.1 - 0.087 12.8 0.6 0.5 10.3 0.1 2.2 2 0 0 2 2 2 0 Tyrosine phosphatase family Peptidase_C74 PF12387.8 EFO62970.1 - 0.27 10.7 4.5 0.73 9.3 4.5 1.7 1 0 0 1 1 1 0 Pestivirus NS2 peptidase RuBisCO_large_N PF02788.16 EFO62971.1 - 0.021 15.0 0.1 0.024 14.8 0.1 1.2 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, N-terminal domain UPF0242 PF06785.11 EFO62972.1 - 0.011 15.8 2.5 0.011 15.8 2.5 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus SlyX PF04102.12 EFO62972.1 - 0.27 11.9 11.1 2.4 8.9 1.3 4.0 2 1 2 4 4 4 0 SlyX DUF16 PF01519.16 EFO62972.1 - 2.2 8.8 5.6 17 6.0 1.0 3.0 2 1 1 3 3 3 0 Protein of unknown function DUF16 Baculo_PEP_C PF04513.12 EFO62972.1 - 3.1 7.8 8.7 2 8.5 6.2 2.1 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Ank_2 PF12796.7 EFO62973.1 - 5.9e-36 122.9 9.0 9.6e-09 35.7 0.1 5.3 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62973.1 - 4.6e-20 71.4 8.7 9.3e-05 22.6 0.0 6.7 4 2 3 7 7 7 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62973.1 - 4.1e-14 52.7 7.4 0.002 18.6 0.0 7.7 7 1 1 8 8 8 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO62973.1 - 1.2e-13 50.8 8.9 0.0039 17.6 0.0 7.3 8 0 0 8 8 8 4 Ankyrin repeat Ank_3 PF13606.6 EFO62973.1 - 6.5e-12 44.5 9.5 0.32 11.7 0.0 9.0 9 0 0 9 9 9 3 Ankyrin repeat Ank_2 PF12796.7 EFO62974.1 - 8.7e-37 125.6 11.4 1.8e-16 60.5 0.2 4.6 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62974.1 - 4.9e-19 68.1 3.8 0.0027 18.0 0.1 6.1 2 2 4 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO62974.1 - 1.2e-17 63.5 4.8 0.0057 17.0 0.0 7.2 7 0 0 7 7 7 3 Ankyrin repeat Ank_3 PF13606.6 EFO62974.1 - 8.1e-14 50.4 3.7 0.023 15.2 0.0 8.1 8 0 0 8 8 8 3 Ankyrin repeat Ank_4 PF13637.6 EFO62974.1 - 1.8e-11 44.4 3.1 0.0088 16.6 0.0 5.8 2 2 5 7 7 7 6 Ankyrin repeats (many copies) SlyX PF04102.12 EFO62974.1 - 0.19 12.4 0.1 0.19 12.4 0.1 7.8 5 2 3 8 8 8 0 SlyX BRCA-2_helical PF09169.10 EFO62974.1 - 0.83 9.3 4.3 12 5.5 3.9 2.7 2 0 0 2 2 2 0 BRCA2, helical CSN7a_helixI PF18392.1 EFO62974.1 - 5.6 7.0 7.2 2.5 8.0 0.6 3.3 3 0 0 3 3 3 0 COP9 signalosome complex subunit 7a helix I domain Ank_2 PF12796.7 EFO62975.1 - 1.3e-40 137.9 5.7 2e-11 44.3 0.1 4.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62975.1 - 1.8e-28 98.5 6.9 1.2e-13 51.2 0.0 6.8 4 2 2 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO62975.1 - 3.1e-25 87.5 2.8 8.1e-06 26.1 0.0 8.0 7 1 1 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 EFO62975.1 - 7.6e-21 73.9 1.7 2.3e-06 27.8 0.0 6.3 3 2 2 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62975.1 - 5.8e-19 66.2 7.4 0.005 17.2 0.0 8.9 9 0 0 9 9 9 5 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO62975.1 - 1.8e-09 37.3 17.0 1.8e-09 37.3 17.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO62975.1 - 2.4 8.1 18.8 7.1 6.6 16.8 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Ank_2 PF12796.7 EFO62976.1 - 7.8e-44 148.2 8.0 5.6e-15 55.7 0.1 6.1 3 2 3 6 6 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62976.1 - 4.5e-27 93.8 8.7 0.00071 19.8 0.1 7.7 3 1 4 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62976.1 - 2.6e-24 82.6 5.2 0.00015 21.9 0.0 8.1 8 0 0 8 8 7 4 Ankyrin repeat Ank PF00023.30 EFO62976.1 - 1.1e-23 82.6 12.0 4e-05 23.9 0.0 8.4 8 1 0 8 8 7 4 Ankyrin repeat Ank_4 PF13637.6 EFO62976.1 - 6.4e-22 77.6 5.4 2.3e-08 34.4 0.1 6.7 4 1 3 7 7 7 5 Ankyrin repeats (many copies) PKcGMP_CC PF16808.5 EFO62976.1 - 2.7e-06 27.1 6.4 0.00094 19.0 0.6 2.9 2 0 0 2 2 2 2 Coiled-coil N-terminus of cGMP-dependent protein kinase ATG16 PF08614.11 EFO62976.1 - 7.7e-05 23.0 39.0 0.0015 18.8 26.1 2.2 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) bZIP_1 PF00170.21 EFO62976.1 - 0.00017 21.6 20.1 0.043 13.9 1.1 4.8 3 2 2 5 5 4 2 bZIP transcription factor Atg14 PF10186.9 EFO62976.1 - 0.0021 17.2 27.2 0.075 12.1 5.4 2.2 1 1 1 2 2 2 2 Vacuolar sorting 38 and autophagy-related subunit 14 SOGA PF11365.8 EFO62976.1 - 0.013 16.6 27.6 0.15 13.2 5.7 4.2 1 1 3 4 4 4 0 Protein SOGA DNA_Packaging PF11053.8 EFO62976.1 - 0.04 13.8 0.6 0.17 11.8 0.6 2.0 1 0 0 1 1 1 0 Terminase DNA packaging enzyme Leu_zip PF15294.6 EFO62976.1 - 0.076 12.5 32.4 0.15 11.5 12.6 2.2 1 1 1 2 2 2 0 Leucine zipper 3HCDH_RFF PF18321.1 EFO62976.1 - 0.082 13.4 0.8 10 6.6 0.0 3.7 3 0 0 3 3 3 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain CENP-F_leu_zip PF10473.9 EFO62976.1 - 0.15 12.1 38.0 0.17 11.9 10.8 3.3 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Myosin_tail_1 PF01576.19 EFO62976.1 - 0.15 9.8 28.3 0.22 9.3 28.3 1.1 1 0 0 1 1 1 0 Myosin tail DUF4201 PF13870.6 EFO62976.1 - 0.19 11.4 27.2 0.039 13.7 11.9 2.6 1 1 1 3 3 3 0 Domain of unknown function (DUF4201) Cep57_CLD PF14073.6 EFO62976.1 - 0.19 11.7 32.1 0.17 11.9 20.9 2.4 1 1 1 2 2 2 0 Centrosome localisation domain of Cep57 TMCO5 PF14992.6 EFO62976.1 - 0.22 11.1 28.8 1.7 8.2 22.6 3.1 1 1 1 2 2 2 0 TMCO5 family DUF641 PF04859.12 EFO62976.1 - 0.34 11.3 28.1 0.11 12.8 1.6 4.0 2 2 2 4 4 4 0 Plant protein of unknown function (DUF641) ZapB PF06005.12 EFO62976.1 - 0.52 10.8 34.2 5.1 7.6 8.9 5.0 1 1 3 4 4 4 0 Cell division protein ZapB DUF3450 PF11932.8 EFO62976.1 - 0.59 9.4 38.2 1.3 8.2 9.1 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) TPR_MLP1_2 PF07926.12 EFO62976.1 - 1.1 9.3 40.3 7.9 6.6 1.7 4.5 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 EFO62976.1 - 1.4 7.8 36.2 2.8 6.7 10.5 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein KH_9 PF17904.1 EFO62976.1 - 1.5 9.3 5.1 98 3.4 5.1 2.7 1 1 0 1 1 1 0 FMRP KH0 domain Jnk-SapK_ap_N PF09744.9 EFO62976.1 - 1.5 9.0 32.7 0.29 11.3 2.3 3.9 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 DUF2968 PF11180.8 EFO62976.1 - 1.5 8.4 27.3 1.7 8.2 4.8 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2968) CENP-H PF05837.12 EFO62976.1 - 2.1 8.8 39.5 0.048 14.1 9.2 3.9 1 1 3 4 4 4 0 Centromere protein H (CENP-H) ADIP PF11559.8 EFO62976.1 - 3.3 7.8 38.7 5.2 7.1 10.3 4.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding HAP1_N PF04849.13 EFO62976.1 - 3.3 6.8 35.1 1.8 7.7 22.7 2.7 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Tropomyosin PF00261.20 EFO62976.1 - 4.2 6.7 28.5 5.7 6.2 27.9 1.6 1 1 0 1 1 1 0 Tropomyosin FAM76 PF16046.5 EFO62976.1 - 4.4 6.6 29.0 4.9 6.4 17.8 2.5 1 1 0 2 2 2 0 FAM76 protein NAD_binding_2 PF03446.15 EFO62976.1 - 5.9 7.0 11.1 3.4 7.8 0.0 3.3 3 0 0 3 3 3 0 NAD binding domain of 6-phosphogluconate dehydrogenase KASH_CCD PF14662.6 EFO62976.1 - 7.9 6.3 39.0 4.1 7.2 11.3 3.3 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH TPR_14 PF13428.6 EFO62977.1 - 1.4e-09 38.0 6.5 0.2 12.6 0.0 6.2 2 2 5 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFO62977.1 - 3.7e-09 37.0 12.1 2.9e-05 24.5 0.6 4.6 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFO62977.1 - 3.8e-09 36.0 11.0 0.25 11.3 0.0 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFO62977.1 - 4.2e-09 36.6 10.7 0.00037 20.7 0.2 4.8 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFO62977.1 - 2.5e-08 33.7 0.5 3.1e-05 24.0 0.7 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFO62977.1 - 5.2e-06 26.2 12.8 0.32 11.2 0.0 6.2 7 0 0 7 7 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFO62977.1 - 9.4e-06 25.8 3.4 0.0032 17.7 0.2 3.8 3 2 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EFO62977.1 - 2.6e-05 24.1 10.5 0.63 10.4 0.4 5.7 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFO62977.1 - 5.5e-05 22.9 7.8 0.11 12.5 0.0 4.7 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFO62977.1 - 0.00047 19.9 6.1 2 8.4 0.2 4.2 5 0 0 5 5 3 2 Tetratricopeptide repeat TPR_20 PF14561.6 EFO62977.1 - 0.0019 18.5 4.1 0.0047 17.2 0.3 3.1 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 EFO62977.1 - 0.0022 17.3 0.9 0.84 8.8 0.2 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFO62977.1 - 0.0033 18.0 7.7 0.024 15.2 0.1 4.6 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFO62977.1 - 0.0069 17.0 15.0 0.6 10.8 0.3 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_4 PF07721.14 EFO62977.1 - 0.0091 16.5 9.6 0.2 12.4 0.2 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EFO62977.1 - 0.015 14.7 1.7 0.068 12.5 1.5 2.3 1 1 0 1 1 1 0 MalT-like TPR region Wzy_C_2 PF11846.8 EFO62977.1 - 0.041 13.8 0.2 0.88 9.5 0.0 2.7 3 0 0 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal TPR_11 PF13414.6 EFO62977.1 - 8.8 6.1 9.3 1.4 8.7 0.2 3.7 5 0 0 5 5 5 0 TPR repeat DHHC PF01529.20 EFO62979.1 - 9.7e-27 93.7 22.4 9.7e-27 93.7 22.4 2.8 2 2 0 2 2 2 1 DHHC palmitoyltransferase TA_inhibitor PF17574.2 EFO62979.1 - 0.067 13.2 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Inhibitor of toxin/antitoxin system (Gp4.5) LCM PF04072.14 EFO62980.1 - 9.6e-13 48.5 0.0 3.2e-12 46.8 0.0 1.7 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase Ribosomal_S8 PF00410.19 EFO62981.1 - 6.5e-21 74.6 0.2 9.4e-21 74.1 0.2 1.2 1 1 0 1 1 1 1 Ribosomal protein S8 ELFV_dehydrog_N PF02812.18 EFO62981.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain SMC_N PF02463.19 EFO62982.1 - 9.7e-34 116.7 0.0 2.1e-33 115.6 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFO62982.1 - 9e-13 48.7 0.2 3e-05 24.0 0.0 3.1 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFO62982.1 - 1.5e-10 41.9 0.1 1.5e-10 41.9 0.1 5.9 3 2 1 4 4 4 1 AAA domain SMC_hinge PF06470.13 EFO62982.1 - 3.6e-07 30.5 0.0 1.4e-06 28.6 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_29 PF13555.6 EFO62982.1 - 3.1e-05 23.6 0.0 6.3e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Proteasome PF00227.26 EFO62983.1 - 5.7e-43 146.6 0.0 6.4e-43 146.5 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit PYC_OADA PF02436.18 EFO62984.1 - 1.3e-50 171.9 0.0 2.2e-50 171.2 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Carboxyl_trans PF01039.22 EFO62984.1 - 1.6e-26 93.1 1.7 5.8e-26 91.2 1.7 1.8 1 1 0 1 1 1 1 Carboxyl transferase domain HMGL-like PF00682.19 EFO62984.1 - 1.4e-15 57.6 0.0 3.4e-15 56.3 0.0 1.7 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl_2 PF13533.6 EFO62984.1 - 1.8e-08 34.1 0.0 2.6e-07 30.3 0.2 2.3 1 1 1 2 2 2 1 Biotin-lipoyl like Biotin_lipoyl PF00364.22 EFO62984.1 - 6.8e-08 32.2 0.1 1.7e-07 31.0 0.1 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme HlyD_D23 PF16576.5 EFO62984.1 - 0.00017 20.8 0.1 0.0013 18.0 0.1 2.3 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion ACCA PF03255.14 EFO62984.1 - 0.076 12.9 1.2 0.17 11.8 0.0 2.2 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Sigma54_activ_2 PF14532.6 EFO62984.1 - 0.081 13.0 0.0 0.25 11.5 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_assoc_2 PF16193.5 EFO62984.1 - 0.1 13.0 0.0 0.32 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA C-terminal domain zf-C3HC4_2 PF13923.6 EFO62984.1 - 1.7 8.6 6.0 3.2 7.7 2.2 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Toprim_Crpt PF13342.6 EFO62985.1 - 0.083 12.9 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 C-terminal repeat of topoisomerase DUF4140 PF13600.6 EFO62985.1 - 0.2 12.1 2.5 0.23 11.9 0.3 2.1 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Na_H_Exchanger PF00999.21 EFO62986.1 - 1.2e-52 179.0 41.0 1.5e-52 178.6 41.0 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Tropomyosin PF00261.20 EFO62987.1 - 0.0017 17.7 6.8 0.0017 17.7 6.8 2.7 2 1 0 2 2 2 2 Tropomyosin Peptidase_S78_2 PF14550.6 EFO62987.1 - 0.021 14.9 0.7 0.021 14.9 0.7 2.0 2 0 0 2 2 2 0 Putative phage serine protease XkdF DUF3450 PF11932.8 EFO62987.1 - 0.049 12.9 18.9 0.26 10.6 6.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) bZIP_2 PF07716.15 EFO62987.1 - 0.28 11.3 0.2 0.28 11.3 0.2 4.0 4 1 1 5 5 5 0 Basic region leucine zipper DUF948 PF06103.11 EFO62987.1 - 0.63 10.3 4.5 0.83 9.9 0.2 2.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Spc7 PF08317.11 EFO62987.1 - 1 8.2 28.6 0.61 8.9 11.6 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein ADIP PF11559.8 EFO62987.1 - 3.1 7.9 27.6 0.56 10.3 8.1 3.4 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding DUF1664 PF07889.12 EFO62987.1 - 6.1 6.9 15.4 0.44 10.6 2.0 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF4200 PF13863.6 EFO62987.1 - 10 6.6 28.0 1.4 9.3 10.1 2.9 1 1 0 2 2 2 0 Domain of unknown function (DUF4200) WD40 PF00400.32 EFO62988.1 - 2.5e-22 78.8 14.1 0.0011 19.7 0.0 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO62988.1 - 6.8e-07 29.5 0.1 0.012 15.9 0.0 4.1 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 EFO62988.1 - 0.023 14.4 0.3 0.49 10.1 0.0 3.0 1 1 2 3 3 3 0 TUP1-like enhancer of split Nucleoporin_N PF08801.11 EFO62988.1 - 0.054 12.2 0.1 0.31 9.7 0.1 2.1 1 1 1 2 2 2 0 Nup133 N terminal like PQQ_3 PF13570.6 EFO62988.1 - 0.07 13.6 8.4 0.2 12.2 0.1 4.2 5 0 0 5 5 5 0 PQQ-like domain DUF3135 PF11333.8 EFO62989.1 - 0.02 15.1 0.0 0.041 14.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3135) FlaC_arch PF05377.11 EFO62990.1 - 0.0051 17.2 7.8 1.4 9.4 0.2 4.5 4 1 0 4 4 4 1 Flagella accessory protein C (FlaC) TSC22 PF01166.18 EFO62990.1 - 0.026 14.8 2.9 9.3 6.6 0.1 3.6 3 0 0 3 3 3 0 TSC-22/dip/bun family Vps23_core PF09454.10 EFO62990.1 - 0.11 12.5 3.5 3.4 7.7 0.1 3.1 3 0 0 3 3 3 0 Vps23 core domain DUF2681 PF10883.8 EFO62990.1 - 0.14 12.6 0.4 0.14 12.6 0.4 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) HALZ PF02183.18 EFO62990.1 - 0.16 12.3 7.1 13 6.1 0.1 3.7 4 0 0 4 4 3 0 Homeobox associated leucine zipper SYCE1 PF15233.6 EFO62990.1 - 0.26 11.3 10.5 0.096 12.7 6.4 2.3 1 1 0 2 2 2 0 Synaptonemal complex central element protein 1 Spc29 PF17082.5 EFO62990.1 - 0.3 10.9 7.0 0.13 12.1 1.7 2.6 1 1 1 3 3 3 0 Spindle Pole Component 29 DMPK_coil PF08826.10 EFO62990.1 - 0.8 9.9 8.2 7.3 6.8 0.1 3.7 3 0 0 3 3 3 0 DMPK coiled coil domain like Csm1_N PF18504.1 EFO62990.1 - 1 9.7 12.1 1.3 9.4 0.4 3.5 3 0 0 3 3 3 0 Csm1 N-terminal domain DUF16 PF01519.16 EFO62990.1 - 1.3 9.6 14.9 3.5 8.2 0.9 3.4 2 1 1 3 3 3 0 Protein of unknown function DUF16 DUF641 PF04859.12 EFO62990.1 - 2 8.8 13.8 1.5 9.1 1.8 3.2 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) ZapD PF07072.11 EFO62990.1 - 2.3 7.9 10.3 9.5 5.9 0.3 2.3 2 0 0 2 2 2 0 Cell division protein bZIP_2 PF07716.15 EFO62990.1 - 3.1 8.0 10.4 18 5.5 0.1 4.2 4 0 0 4 4 4 0 Basic region leucine zipper DivIC PF04977.15 EFO62990.1 - 8.2 6.3 15.4 1.8 8.4 2.4 3.4 3 0 0 3 3 3 0 Septum formation initiator KLRAQ PF10205.9 EFO62990.1 - 8.4 6.7 14.8 7 6.9 5.0 3.1 2 1 1 3 3 3 0 Predicted coiled-coil domain-containing protein TMF_DNA_bd PF12329.8 EFO62990.1 - 8.8 6.4 19.1 1.3 9.1 2.4 4.2 3 1 2 5 5 5 0 TATA element modulatory factor 1 DNA binding Ank_2 PF12796.7 EFO62991.1 - 3.3e-13 50.0 0.1 8e-13 48.8 0.2 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO62991.1 - 7.8e-08 32.7 0.1 0.00078 20.0 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62991.1 - 9.2e-06 25.6 0.2 0.027 15.0 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EFO62991.1 - 2.2e-05 24.6 0.1 0.0001 22.5 0.1 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EFO62991.1 - 0.00096 19.5 0.1 0.83 10.2 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat F5_F8_type_C PF00754.25 EFO62992.1 - 0.00022 21.3 0.0 0.00045 20.3 0.0 1.5 1 1 0 1 1 1 1 F5/8 type C domain DUF5000 PF16391.5 EFO62992.1 - 0.17 12.0 0.0 15 5.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function GIT_CC PF16559.5 EFO62993.1 - 0.067 13.1 1.1 0.14 12.1 1.1 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor ATP_bind_1 PF03029.17 EFO62994.1 - 5.2e-36 124.6 0.0 5.9e-36 124.5 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 EFO62994.1 - 0.00013 22.5 0.0 0.00019 21.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFO62994.1 - 0.00015 22.1 0.0 0.0068 16.7 0.0 2.6 1 1 1 2 2 2 1 AAA domain KTI12 PF08433.10 EFO62994.1 - 0.00035 20.1 0.0 0.00058 19.4 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 CbiA PF01656.23 EFO62994.1 - 0.00056 20.0 0.0 0.00068 19.7 0.0 1.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA PF00004.29 EFO62994.1 - 0.00074 19.9 0.0 0.0012 19.2 0.0 1.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EFO62994.1 - 0.00087 18.7 0.0 0.0014 18.1 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI CLP1_P PF16575.5 EFO62994.1 - 0.0019 18.0 0.0 0.011 15.6 0.0 1.9 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_31 PF13614.6 EFO62994.1 - 0.0046 16.9 0.0 0.026 14.5 0.0 2.0 1 1 1 3 3 3 1 AAA domain ArsA_ATPase PF02374.15 EFO62994.1 - 0.0052 16.0 0.0 0.0064 15.7 0.0 1.2 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_28 PF13521.6 EFO62994.1 - 0.0054 17.0 0.1 0.0093 16.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EFO62994.1 - 0.0058 17.1 0.0 0.012 16.1 0.0 2.0 1 1 0 1 1 1 1 ABC transporter FeoB_N PF02421.18 EFO62994.1 - 0.0077 15.8 0.0 0.079 12.5 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EFO62994.1 - 0.0082 16.2 0.0 0.082 13.0 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 EFO62994.1 - 0.0098 15.6 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EFO62994.1 - 0.011 15.5 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EFO62994.1 - 0.011 15.0 0.0 0.017 14.4 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.22 EFO62994.1 - 0.014 15.8 0.0 0.026 14.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 EFO62994.1 - 0.014 15.4 0.0 0.024 14.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain NTPase_1 PF03266.15 EFO62994.1 - 0.014 15.3 0.0 0.028 14.4 0.0 1.5 1 0 0 1 1 1 0 NTPase MeaB PF03308.16 EFO62994.1 - 0.016 14.2 0.0 0.023 13.7 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_29 PF13555.6 EFO62994.1 - 0.022 14.5 0.0 0.049 13.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 EFO62994.1 - 0.045 13.9 0.0 0.058 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EFO62994.1 - 0.053 13.1 0.0 0.12 11.9 0.0 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 EFO62994.1 - 0.063 13.7 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EFO62994.1 - 0.065 13.2 0.0 0.09 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Ploopntkinase3 PF18751.1 EFO62994.1 - 0.07 13.0 0.0 0.29 11.0 0.0 1.9 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_13 PF13166.6 EFO62994.1 - 0.081 11.6 0.0 0.1 11.2 0.0 1.1 1 0 0 1 1 1 0 AAA domain CBP_BcsQ PF06564.12 EFO62994.1 - 0.096 12.1 0.0 0.73 9.3 0.0 2.2 2 1 1 3 3 3 0 Cellulose biosynthesis protein BcsQ SRPRB PF09439.10 EFO62994.1 - 0.1 12.0 0.0 10 5.5 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 EFO62994.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EFO62994.1 - 0.15 12.1 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EFO62994.1 - 0.16 11.5 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region APS_kinase PF01583.20 EFO62994.1 - 0.16 11.9 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase ATPase_2 PF01637.18 EFO62994.1 - 0.16 11.8 0.0 4.3 7.2 0.0 2.1 1 1 0 2 2 2 0 ATPase domain predominantly from Archaea MobB PF03205.14 EFO62994.1 - 0.17 11.8 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B GTP_EFTU PF00009.27 EFO62994.1 - 0.2 11.2 0.0 1.4 8.5 0.0 2.2 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain SRP54 PF00448.22 EFO62994.1 - 0.2 11.3 0.0 0.36 10.4 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Ank_2 PF12796.7 EFO62995.1 - 2.2e-30 105.1 16.1 1.9e-12 47.6 0.4 5.3 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 EFO62995.1 - 1.8e-16 59.7 1.0 0.32 11.5 0.1 7.5 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.6 EFO62995.1 - 5.6e-15 55.5 8.8 6.9e-07 29.7 0.1 6.9 5 2 1 6 6 6 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62995.1 - 2.9e-14 51.7 6.6 0.42 11.3 0.0 7.8 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 EFO62995.1 - 2.7e-11 43.5 9.0 0.038 14.3 0.2 6.7 4 1 2 6 6 6 4 Ankyrin repeats (many copies) ATG16 PF08614.11 EFO62995.1 - 6.2e-08 33.1 385.8 0.0063 16.8 28.7 20.1 1 1 19 21 21 21 8 Autophagy protein 16 (ATG16) KASH_CCD PF14662.6 EFO62995.1 - 0.0011 18.9 29.5 0.0011 18.9 29.5 17.6 3 2 12 16 16 16 2 Coiled-coil region of CCDC155 or KASH Sec2p PF06428.11 EFO62995.1 - 0.0043 17.0 7.3 0.0043 17.0 7.3 24.2 9 6 13 26 26 26 1 GDP/GTP exchange factor Sec2p Ank_2 PF12796.7 EFO62996.1 - 3.4e-41 139.7 0.4 7.1e-10 39.3 0.0 5.5 1 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO62996.1 - 5.5e-21 72.4 3.1 0.079 13.5 0.0 8.8 7 1 1 8 8 8 5 Ankyrin repeat Ank_4 PF13637.6 EFO62996.1 - 1.5e-17 63.7 1.9 0.00031 21.2 0.0 5.7 4 2 3 7 7 7 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO62996.1 - 5.2e-16 58.3 8.0 0.31 11.6 0.1 9.2 8 1 0 8 8 8 3 Ankyrin repeat Ank_5 PF13857.6 EFO62996.1 - 9.5e-16 57.7 1.6 0.023 15.0 0.0 6.7 4 1 2 6 6 6 5 Ankyrin repeats (many copies) Cep57_CLD_2 PF14197.6 EFO62996.1 - 0.0028 17.7 2.3 0.0028 17.7 2.3 7.7 7 1 2 9 9 9 2 Centrosome localisation domain of PPC89 Ten1_2 PF15490.6 EFO62996.1 - 0.008 15.9 0.1 0.88 9.3 0.1 3.2 2 0 0 2 2 2 1 Telomere-capping, CST complex subunit TSC22 PF01166.18 EFO62996.1 - 0.58 10.5 0.0 0.58 10.5 0.0 8.2 11 1 1 12 12 12 0 TSC-22/dip/bun family IL1_propep PF02394.16 EFO62996.1 - 0.99 10.4 5.9 0.62 11.0 1.2 3.2 2 1 1 3 3 3 0 Interleukin-1 propeptide WD40 PF00400.32 EFO62997.1 - 0.00012 22.8 3.3 0.15 12.9 0.2 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO62997.1 - 0.0028 17.9 0.0 0.018 15.4 0.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain F5_F8_type_C PF00754.25 EFO62998.1 - 0.00024 21.2 0.0 0.0005 20.2 0.0 1.5 1 1 0 1 1 1 1 F5/8 type C domain DUF5000 PF16391.5 EFO62998.1 - 0.19 11.8 0.0 16 5.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function Ank_2 PF12796.7 EFO62999.1 - 3.7e-43 146.0 2.0 3.8e-11 43.4 0.0 5.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO62999.1 - 3.5e-25 87.7 6.5 0.00034 20.8 0.0 7.4 6 1 1 7 7 7 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO62999.1 - 3.2e-24 85.0 6.9 1.1e-05 25.9 0.1 6.1 4 2 1 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO62999.1 - 3.6e-24 82.2 1.2 0.0081 16.6 0.0 9.5 9 0 0 9 9 9 5 Ankyrin repeat Ank PF00023.30 EFO62999.1 - 4.9e-17 61.5 16.0 0.031 14.7 0.0 8.5 7 1 1 8 8 8 5 Ankyrin repeat Lebercilin PF15619.6 EFO62999.1 - 0.00027 20.6 28.6 0.0046 16.7 12.0 2.4 1 1 1 2 2 2 2 Ciliary protein causing Leber congenital amaurosis disease AAA_13 PF13166.6 EFO62999.1 - 0.00051 18.8 19.8 0.00076 18.3 12.1 2.0 1 1 1 2 2 2 1 AAA domain BRE1 PF08647.11 EFO62999.1 - 0.00077 19.5 22.1 0.0043 17.1 6.6 3.4 3 0 0 3 3 3 1 BRE1 E3 ubiquitin ligase CENP-F_leu_zip PF10473.9 EFO62999.1 - 0.00082 19.4 31.8 0.062 13.3 9.8 3.3 2 1 1 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tup_N PF08581.10 EFO62999.1 - 0.0062 16.8 2.5 0.0062 16.8 2.5 4.2 2 1 3 5 5 5 1 Tup N-terminal Takusan PF04822.13 EFO62999.1 - 0.0071 16.2 0.3 0.0071 16.2 0.3 2.6 2 0 0 2 2 2 1 Takusan DUF4201 PF13870.6 EFO62999.1 - 0.018 14.8 21.8 0.014 15.1 15.3 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) TMF_TATA_bd PF12325.8 EFO62999.1 - 0.021 15.1 34.3 0.31 11.3 13.1 3.3 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF4686 PF15742.5 EFO62999.1 - 0.023 13.9 19.7 0.038 13.1 19.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) TPR_MLP1_2 PF07926.12 EFO62999.1 - 0.024 14.7 31.3 0.042 13.9 3.2 3.7 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein Fez1 PF06818.15 EFO62999.1 - 0.043 14.3 26.4 0.31 11.5 12.6 2.3 1 1 1 2 2 2 0 Fez1 GAS PF13851.6 EFO62999.1 - 0.068 12.5 27.9 0.051 12.9 12.6 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Phage_GP20 PF06810.11 EFO62999.1 - 0.076 12.8 22.0 0.1 12.4 9.4 3.7 2 1 2 4 4 3 0 Phage minor structural protein GP20 MscS_porin PF12795.7 EFO62999.1 - 0.08 12.5 19.2 0.11 12.1 16.7 2.3 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain DUF5082 PF16888.5 EFO62999.1 - 0.12 12.7 13.0 0.6 10.4 1.8 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF5082) Spc7 PF08317.11 EFO62999.1 - 0.17 10.7 32.1 0.029 13.2 13.9 2.8 1 1 2 3 3 3 0 Spc7 kinetochore protein DUF1664 PF07889.12 EFO62999.1 - 0.54 10.3 16.0 0.12 12.4 3.3 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) Cep57_CLD_2 PF14197.6 EFO62999.1 - 0.95 9.6 23.2 8.6 6.5 1.1 4.4 3 1 1 4 4 4 0 Centrosome localisation domain of PPC89 Prominin PF05478.11 EFO62999.1 - 1 7.2 16.0 0.12 10.3 2.8 2.7 1 1 2 3 3 3 0 Prominin Fib_alpha PF08702.10 EFO62999.1 - 1.4 9.1 14.4 8.4 6.6 1.8 3.9 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.9 EFO62999.1 - 1.4 9.2 18.8 0.19 12.0 4.7 3.6 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ATG16 PF08614.11 EFO62999.1 - 1.8 8.8 33.0 1.2 9.4 7.2 2.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Bacillus_HBL PF05791.11 EFO62999.1 - 1.9 8.3 4.3 15 5.4 0.6 2.8 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) YabA PF06156.13 EFO62999.1 - 2.2 8.9 18.9 0.085 13.5 1.9 3.6 2 1 0 2 2 1 0 Initiation control protein YabA HCMV_UL139 PF12507.8 EFO62999.1 - 2.4 8.6 10.6 0.19 12.1 3.1 2.3 2 0 0 2 2 2 0 Human Cytomegalovirus UL139 protein DUF4407 PF14362.6 EFO62999.1 - 3.1 7.1 22.0 10 5.4 20.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) HOOK PF05622.12 EFO62999.1 - 4.1 5.4 34.1 2.4 6.2 16.6 2.3 1 1 1 2 2 2 0 HOOK protein KxDL PF10241.9 EFO62999.1 - 4.3 7.7 8.0 6.5 7.1 0.1 4.0 1 1 2 4 4 4 0 Uncharacterized conserved protein DUF3584 PF12128.8 EFO62999.1 - 5 4.5 28.3 0.049 11.2 15.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) FlaC_arch PF05377.11 EFO62999.1 - 6.1 7.3 17.2 5.4 7.5 0.2 5.1 3 2 2 5 5 5 0 Flagella accessory protein C (FlaC) Laminin_II PF06009.12 EFO62999.1 - 6.2 6.8 16.6 1.3 9.1 2.5 3.2 1 1 2 3 3 3 0 Laminin Domain II Med9 PF07544.13 EFO62999.1 - 9.1 6.5 14.5 0.53 10.4 1.0 3.4 1 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 ENOD93 PF03386.14 EFO63002.1 - 0.07 13.0 0.8 0.15 11.9 0.8 1.5 1 0 0 1 1 1 0 Early nodulin 93 ENOD93 protein WD40 PF00400.32 EFO63003.1 - 1.2e-20 73.4 11.3 9.2e-07 29.5 0.0 7.0 8 0 0 8 8 8 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EFO63003.1 - 0.00015 20.9 0.1 0.0071 15.3 0.0 3.3 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 EFO63003.1 - 0.0039 17.4 0.0 3.8 7.9 0.0 3.9 1 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nbas_N PF15492.6 EFO63003.1 - 0.026 13.9 0.0 2 7.6 0.0 2.5 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Str_synth PF03088.16 EFO63003.1 - 0.039 14.1 0.0 4.8 7.4 0.0 3.2 4 0 0 4 4 4 0 Strictosidine synthase zf-CHY PF05495.12 EFO63004.1 - 4.9e-12 46.2 11.5 4.9e-12 46.2 11.5 4.2 1 1 2 3 3 3 1 CHY zinc finger zinc_ribbon_6 PF14599.6 EFO63004.1 - 7.7e-05 22.6 0.1 7.7e-05 22.6 0.1 4.7 4 2 1 5 5 5 1 Zinc-ribbon HypA PF01155.19 EFO63004.1 - 0.023 14.7 1.7 0.023 14.7 1.7 4.6 2 2 1 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DNA_pol_B_exo1 PF03104.19 EFO63005.1 - 7.4e-56 189.7 0.0 4.3e-55 187.2 0.0 2.3 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 EFO63005.1 - 9e-13 47.7 1.5 9.2e-08 31.2 0.2 3.3 3 0 0 3 3 3 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 EFO63005.1 - 0.00026 20.8 0.7 0.0021 17.8 0.7 2.2 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 EFO63005.1 - 0.0063 16.5 0.0 0.0063 16.5 0.0 2.3 3 0 0 3 3 3 1 RNase_H superfamily VSP PF03302.13 EFO63006.1 - 2.7e-78 263.6 156.5 2.1e-45 155.3 28.2 5.1 1 1 4 5 5 5 4 Giardia variant-specific surface protein zf-C3HC4_3 PF13920.6 EFO63011.1 - 1.5e-07 31.1 10.1 3.6e-07 29.9 10.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFO63011.1 - 5.6e-06 26.6 8.3 5.6e-06 26.6 8.3 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFO63011.1 - 1.1e-05 25.1 7.9 2.3e-05 24.1 7.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFO63011.1 - 0.00022 21.1 8.6 0.00052 19.9 8.6 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFO63011.1 - 0.0011 18.8 8.0 0.0023 17.7 8.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFO63011.1 - 0.017 15.1 6.0 0.038 14.0 6.0 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.7 EFO63011.1 - 0.31 11.3 3.0 1 9.7 3.0 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EFO63011.1 - 1.1 9.5 7.9 3.1 8.0 7.9 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EFO63011.1 - 1.4 8.7 6.9 3.7 7.4 6.9 1.8 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_10 PF16685.5 EFO63011.1 - 6.9 6.9 11.8 11 6.3 9.9 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 SF-assemblin PF06705.11 EFO63012.1 - 4.8e-107 356.9 33.8 5.4e-107 356.7 33.8 1.0 1 0 0 1 1 1 1 SF-assemblin/beta giardin DUF713 PF05218.14 EFO63012.1 - 0.055 13.2 7.9 0.034 13.9 2.7 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF713) ApoLp-III PF07464.11 EFO63012.1 - 0.062 13.4 21.3 0.077 13.1 5.8 3.3 1 1 2 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Baculo_PEP_C PF04513.12 EFO63012.1 - 0.07 13.2 17.6 0.58 10.2 4.8 3.7 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus KfrA_N PF11740.8 EFO63012.1 - 0.097 13.4 16.5 0.28 11.9 1.7 2.7 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term DUF1657 PF07870.11 EFO63012.1 - 0.11 12.4 3.5 0.35 10.8 0.1 3.2 2 1 2 4 4 4 0 Protein of unknown function (DUF1657) PIN_8 PF18476.1 EFO63012.1 - 0.46 10.3 22.3 1.4 8.7 6.8 2.7 1 1 2 3 3 3 0 PIN like domain Tup_N PF08581.10 EFO63012.1 - 0.66 10.3 11.9 0.16 12.3 0.7 3.2 2 1 1 3 3 3 0 Tup N-terminal DUF4407 PF14362.6 EFO63012.1 - 1.1 8.6 24.2 4.1 6.7 10.7 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) YlqD PF11068.8 EFO63012.1 - 1.3 9.5 18.5 1.9 8.9 2.3 3.5 1 1 3 4 4 4 0 YlqD protein Exonuc_VII_L PF02601.15 EFO63012.1 - 1.4 8.4 18.9 1.7e+02 1.6 18.9 2.1 1 1 0 1 1 1 0 Exonuclease VII, large subunit Prominin PF05478.11 EFO63012.1 - 1.6 6.6 18.2 0.71 7.7 5.2 1.9 1 1 1 2 2 2 0 Prominin SKA2 PF16740.5 EFO63012.1 - 1.8 8.4 17.4 0.16 11.8 1.1 4.2 1 1 2 4 4 4 0 Spindle and kinetochore-associated protein 2 Phage_Mu_Gam PF07352.12 EFO63012.1 - 2.1 8.2 21.4 2.6 7.9 1.8 4.1 2 1 2 4 4 4 0 Bacteriophage Mu Gam like protein DUF1318 PF07027.12 EFO63012.1 - 2.5 8.6 10.3 11 6.6 3.8 3.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1318) Orbi_VP4 PF05059.12 EFO63014.1 - 0.029 12.4 0.0 0.037 12.1 0.0 1.1 1 0 0 1 1 1 0 Orbivirus VP4 core protein zinc_ribbon_6 PF14599.6 EFO63016.1 - 5e-06 26.4 0.1 6.8e-06 26.0 0.1 1.2 1 0 0 1 1 1 1 Zinc-ribbon HypA PF01155.19 EFO63016.1 - 0.00089 19.3 0.8 0.0011 19.0 0.8 1.2 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 EFO63016.1 - 0.006 16.6 2.1 0.0094 16.0 2.1 1.3 1 0 0 1 1 1 1 Double zinc ribbon Zn-ribbon_8 PF09723.10 EFO63016.1 - 0.015 15.4 5.9 0.036 14.2 5.9 1.6 1 1 0 1 1 1 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 EFO63016.1 - 0.016 14.6 3.4 0.065 12.7 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Zn_ribbon_SprT PF17283.2 EFO63016.1 - 0.046 13.6 1.4 0.046 13.6 1.4 1.9 1 1 1 2 2 2 0 SprT-like zinc ribbon domain zf-C2H2 PF00096.26 EFO63016.1 - 0.38 11.3 4.2 1.4 9.6 0.5 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type Ogr_Delta PF04606.12 EFO63016.1 - 1 9.4 6.0 10 6.2 0.4 2.4 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger NRDD PF13597.6 EFO63016.1 - 1.6 7.4 3.1 2.1 7.0 3.1 1.1 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase VSP PF03302.13 EFO63018.1 - 9.6e-37 126.8 173.9 8.2e-32 110.5 66.8 5.9 1 1 3 4 4 4 3 Giardia variant-specific surface protein LytR_C PF13399.6 EFO63019.1 - 0.042 14.8 0.7 0.1 13.6 0.7 1.7 1 1 0 1 1 1 0 LytR cell envelope-related transcriptional attenuator DUF3793 PF12672.7 EFO63019.1 - 0.045 13.8 0.0 0.074 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3793) Penicillinase_R PF03965.16 EFO63019.1 - 0.064 13.6 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Penicillinase repressor Pkinase PF00069.25 EFO63021.1 - 1.3e-66 224.6 0.2 5.4e-66 222.7 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63021.1 - 2.5e-42 145.0 0.0 5e-42 144.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO63021.1 - 0.00023 20.6 0.1 0.0045 16.3 0.0 2.7 3 0 0 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 EFO63021.1 - 0.046 12.5 0.0 0.078 11.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase CLAMP PF14769.6 EFO63022.1 - 2.7e-18 66.2 0.5 5e-18 65.4 0.5 1.5 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 BBIP10 PF14777.6 EFO63022.1 - 0.023 14.2 0.0 0.063 12.9 0.0 1.6 1 0 0 1 1 1 0 Cilia BBSome complex subunit 10 MIP-T3 PF10243.9 EFO63022.1 - 0.067 13.2 0.9 0.16 11.9 0.3 1.8 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 CH-like domain PAP2 PF01569.21 EFO63024.1 - 1e-22 80.4 9.8 1.4e-22 79.9 7.7 2.0 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EFO63024.1 - 0.0043 16.8 17.0 0.22 11.2 4.6 2.7 1 1 1 2 2 2 2 PAP2 superfamily Claudin_2 PF13903.6 EFO63024.1 - 0.015 15.1 12.5 0.048 13.4 3.1 2.8 2 1 0 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction Kinocilin PF15033.6 EFO63024.1 - 0.022 14.4 7.0 0.04 13.5 0.2 2.9 2 1 1 3 3 3 0 Kinocilin protein DUF2663 PF10864.8 EFO63024.1 - 0.65 10.4 3.8 0.73 10.3 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2663) YjeF_N PF03853.15 EFO63025.1 - 5.4e-38 130.6 0.0 6.5e-38 130.3 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus Ribosomal_S26e PF01283.19 EFO63026.1 - 3.8e-48 162.4 10.3 4.4e-48 162.2 10.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e WD40 PF00400.32 EFO63028.1 - 2.1e-15 56.8 3.0 0.0055 17.5 0.3 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO63028.1 - 3e-07 30.6 0.1 0.11 12.8 0.0 4.9 3 2 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Myotub-related PF06602.14 EFO63030.1 - 1.9e-105 352.7 0.0 1.7e-104 349.6 0.0 2.0 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain Cyclin PF08613.11 EFO63031.1 - 1.4e-06 28.8 0.0 1.7e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EFO63031.1 - 2.6e-05 24.0 0.0 3.6e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Acetyltransf_8 PF13523.6 EFO63031.1 - 0.077 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain LRR_4 PF12799.7 EFO63033.1 - 9.2e-14 51.3 17.2 8.3e-05 22.9 0.2 5.8 4 3 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO63033.1 - 6.8e-13 48.2 8.7 5.2e-06 26.1 0.1 4.0 4 1 0 4 4 4 3 Leucine rich repeat LRR_6 PF13516.6 EFO63033.1 - 1.9e-08 33.7 4.4 7.6 6.9 0.0 7.1 8 0 0 8 8 8 3 Leucine Rich repeat LRR_9 PF14580.6 EFO63033.1 - 2.5e-06 27.1 3.2 0.00027 20.5 0.0 2.8 1 1 1 2 2 2 2 Leucine-rich repeat Pentapeptide_4 PF13599.6 EFO63033.1 - 0.0019 18.3 0.7 3.4 7.9 0.1 3.3 2 1 0 2 2 2 2 Pentapeptide repeats (9 copies) LRR_1 PF00560.33 EFO63033.1 - 0.029 14.9 17.0 2.5 9.0 0.2 6.6 6 1 0 6 6 6 0 Leucine Rich Repeat Ribosomal_S7 PF00177.21 EFO63033.1 - 0.071 12.8 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S7p/S5e LRR_5 PF13306.6 EFO63033.1 - 0.28 11.2 4.1 0.87 9.5 0.4 2.5 2 1 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) Myb_DNA-binding PF00249.31 EFO63034.1 - 5.1e-15 55.4 1.0 1.5e-07 31.4 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFO63034.1 - 5.5e-09 36.1 0.9 1.9e-05 24.8 0.3 2.6 2 1 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFO63034.1 - 0.00016 21.5 0.0 0.00053 19.8 0.0 1.8 1 0 0 1 1 1 1 Myb DNA-binding like DFF-C PF09033.10 EFO63035.1 - 0.018 14.9 0.0 0.022 14.7 0.0 1.1 1 0 0 1 1 1 0 DNA Fragmentation factor 45kDa, C terminal domain Death PF00531.22 EFO63035.1 - 0.043 14.0 0.0 0.072 13.3 0.0 1.6 1 1 0 1 1 1 0 Death domain Ank_2 PF12796.7 EFO63039.1 - 3.4e-42 142.9 5.7 1.9e-10 41.2 0.5 5.7 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank PF00023.30 EFO63039.1 - 2.4e-22 78.3 5.6 0.0045 17.4 0.0 9.3 8 2 1 9 9 9 5 Ankyrin repeat Ank_5 PF13857.6 EFO63039.1 - 1.3e-20 73.2 3.8 0.041 14.2 0.1 8.5 5 3 3 8 8 8 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63039.1 - 3.3e-19 69.0 5.8 0.0013 19.3 0.1 7.9 6 2 2 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63039.1 - 1.5e-18 65.0 4.1 0.33 11.6 0.0 9.1 9 0 0 9 9 9 5 Ankyrin repeat Atg14 PF10186.9 EFO63039.1 - 0.0015 17.7 3.9 0.0043 16.2 3.9 1.7 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4200 PF13863.6 EFO63039.1 - 1.4 9.3 6.1 2.9 8.3 5.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) ParcG PF10274.9 EFO63040.1 - 3e-81 271.9 0.0 3.5e-81 271.7 0.0 1.0 1 0 0 1 1 1 1 Parkin co-regulated protein DCB PF16213.5 EFO63040.1 - 0.1 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 MMS19_C PF12460.8 EFO63040.1 - 0.14 11.2 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 RNAPII transcription regulator C-terminal DUF5382 PF17354.2 EFO63041.1 - 0.05 12.5 0.0 0.073 11.9 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5382) DUF4041 PF13250.6 EFO63042.1 - 0.091 12.6 0.1 0.53 10.2 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4041) G-gamma PF00631.22 EFO63042.1 - 0.11 12.5 0.0 0.4 10.7 0.0 2.0 1 0 0 1 1 1 0 GGL domain Sas10 PF09368.10 EFO63043.1 - 1.1e-13 51.4 4.1 1.1e-13 51.4 4.1 2.5 2 0 0 2 2 2 1 Sas10 C-terminal domain PAP2 PF01569.21 EFO63044.1 - 1.1e-21 77.1 7.5 1.1e-21 77.1 7.5 1.9 2 0 0 2 2 2 1 PAP2 superfamily 7tm_7 PF08395.12 EFO63044.1 - 0.95 8.6 14.9 0.35 10.0 4.3 2.1 2 0 0 2 2 2 0 7tm Chemosensory receptor EAP30 PF04157.16 EFO63045.1 - 4.9e-13 48.9 0.0 1.4e-12 47.4 0.0 1.6 1 1 1 2 2 2 1 EAP30/Vps36 family N2227 PF07942.12 EFO63045.1 - 0.03 13.5 0.1 0.052 12.7 0.1 1.4 1 0 0 1 1 1 0 N2227-like protein Mt_ATP-synt_B PF05405.14 EFO63045.1 - 0.047 13.3 0.3 1 8.9 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) AAA PF00004.29 EFO63046.1 - 2.2e-67 225.5 0.2 4e-39 134.0 0.0 3.3 3 0 0 3 3 3 3 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFO63046.1 - 1.2e-23 82.6 0.4 3.9e-11 42.6 0.0 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_2 PF07724.14 EFO63046.1 - 8.4e-08 32.5 0.0 0.0084 16.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EFO63046.1 - 3.7e-07 30.7 0.0 0.00033 21.1 0.0 3.2 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EFO63046.1 - 5.9e-06 26.6 0.5 0.039 14.2 0.0 4.1 2 1 2 4 4 4 1 AAA domain TIP49 PF06068.13 EFO63046.1 - 1.5e-05 24.4 0.2 0.00012 21.4 0.1 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain ResIII PF04851.15 EFO63046.1 - 9.1e-05 22.5 0.0 0.00076 19.5 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 EFO63046.1 - 0.00085 19.7 0.0 0.14 12.6 0.0 2.7 2 0 0 2 2 2 1 RNA helicase DEAD PF00270.29 EFO63046.1 - 0.007 16.1 0.9 0.062 13.1 0.1 2.9 4 1 0 4 4 3 1 DEAD/DEAH box helicase AAA_18 PF13238.6 EFO63046.1 - 0.018 15.6 0.1 13 6.3 0.1 3.0 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 EFO63046.1 - 0.02 14.9 0.0 1.5 8.9 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 EFO63046.1 - 0.025 14.3 0.0 13 5.5 0.0 3.0 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain DUF963 PF06131.11 EFO63046.1 - 0.026 13.9 0.3 0.053 13.0 0.3 1.5 1 0 0 1 1 1 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) AAA_26 PF13500.6 EFO63046.1 - 0.036 13.9 0.4 0.33 10.7 0.0 2.7 4 0 0 4 4 3 0 AAA domain Vps4_C PF09336.10 EFO63046.1 - 0.042 13.9 0.0 0.65 10.0 0.0 2.7 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain AAA_7 PF12775.7 EFO63046.1 - 0.049 13.1 0.0 0.23 11.0 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_19 PF13245.6 EFO63046.1 - 0.063 13.6 0.1 0.65 10.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EFO63046.1 - 0.1 12.5 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF4988 PF16378.5 EFO63047.1 - 0.018 14.7 4.7 2.1 8.0 0.7 2.8 2 0 0 2 2 2 0 Domain of unknown function FlaC_arch PF05377.11 EFO63047.1 - 0.13 12.7 12.8 0.021 15.2 1.0 4.8 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) YflT PF11181.8 EFO63047.1 - 0.51 10.9 4.7 0.24 11.9 1.1 2.6 2 0 0 2 2 2 0 Heat induced stress protein YflT Gin PF10764.9 EFO63047.1 - 1.3 9.0 4.1 0.59 10.1 0.5 2.2 2 0 0 2 2 2 0 Inhibitor of sigma-G Gin DUF1664 PF07889.12 EFO63047.1 - 7.7 6.6 11.2 5.7 7.0 0.8 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) CarbpepA_inh PF02977.15 EFO63048.1 - 0.0097 15.7 5.9 0.0097 15.7 5.9 6.6 8 1 0 8 8 8 1 Carboxypeptidase A inhibitor She2p PF11435.8 EFO63049.1 - 0.0018 18.0 2.7 0.004 16.8 2.7 1.5 1 0 0 1 1 1 1 RNA binding protein She2p FAST_2 PF08368.12 EFO63049.1 - 0.058 14.2 4.2 1.4 9.7 0.1 3.9 3 0 0 3 3 3 0 FAST kinase-like protein, subdomain 2 MbeD_MobD PF04899.12 EFO63049.1 - 1.2 9.3 12.9 6 7.1 3.6 4.6 4 0 0 4 4 4 0 MbeD/MobD like Glyco_transf_18 PF15024.6 EFO63051.1 - 0.013 14.1 0.2 0.034 12.7 0.2 1.6 1 0 0 1 1 1 0 Glycosyltransferase family 18 Rap1_C PF11626.8 EFO63051.1 - 0.064 13.3 0.3 0.29 11.3 0.3 2.2 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain HCMV_UL139 PF12507.8 EFO63051.1 - 0.082 13.3 6.5 0.032 14.6 2.6 2.5 2 0 0 2 2 2 0 Human Cytomegalovirus UL139 protein ACT_5 PF13710.6 EFO63051.1 - 2 8.3 4.1 7.5 6.5 0.2 3.1 3 0 0 3 3 3 0 ACT domain Chorismate_synt PF01264.21 EFO63056.1 - 0.0017 17.1 0.2 0.0025 16.6 0.2 1.3 1 0 0 1 1 1 1 Chorismate synthase AAA_13 PF13166.6 EFO63056.1 - 0.022 13.4 10.4 0.027 13.2 10.4 1.1 1 0 0 1 1 1 0 AAA domain PspA_IM30 PF04012.12 EFO63056.1 - 0.079 12.5 8.4 0.14 11.7 7.3 1.7 1 1 1 2 2 2 0 PspA/IM30 family Pneumo_M2 PF07380.11 EFO63056.1 - 0.092 13.0 0.2 0.26 11.6 0.2 1.8 1 0 0 1 1 1 0 Pneumovirus M2 protein LemA PF04011.12 EFO63056.1 - 0.21 11.4 5.1 0.35 10.7 5.1 1.4 1 0 0 1 1 1 0 LemA family DUF724 PF05266.14 EFO63056.1 - 0.22 11.4 9.7 0.76 9.6 10.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Phage_GPO PF05929.11 EFO63056.1 - 0.24 11.0 5.1 0.38 10.3 4.7 1.5 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF1323 PF07037.11 EFO63056.1 - 0.34 11.3 3.9 0.3 11.5 0.4 2.6 1 1 2 3 3 3 0 Putative transcription regulator (DUF1323) DUF3829 PF12889.7 EFO63056.1 - 0.38 10.2 6.4 0.63 9.5 6.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3829) DUF3450 PF11932.8 EFO63056.1 - 0.96 8.7 12.5 0.11 11.8 8.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 EFO63056.1 - 1.2 9.1 13.3 0.12 12.4 5.6 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.22 EFO63056.1 - 1.3 9.3 13.4 0.27 11.5 6.4 2.7 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DivIVA PF05103.13 EFO63056.1 - 2 8.5 11.6 2 8.5 5.3 2.7 2 1 1 3 3 3 0 DivIVA protein MCPsignal PF00015.21 EFO63056.1 - 4.4 7.1 9.6 0.75 9.6 5.1 2.0 2 1 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF2203 PF09969.9 EFO63056.1 - 4.5 8.0 7.2 2 9.1 3.9 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) MitMem_reg PF13012.6 EFO63056.1 - 7.7 7.0 7.9 11 6.5 3.4 2.9 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function DEAD PF00270.29 EFO63057.1 - 1.3e-33 116.2 0.3 3e-31 108.5 0.1 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO63057.1 - 3.7e-21 75.5 0.1 7.3e-21 74.6 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4478 PF14793.6 EFO63057.1 - 0.12 12.3 0.1 0.41 10.5 0.0 1.9 2 0 0 2 2 2 0 Pyrimidine/purine nucleotide 5'-monophosphate nucleosidases KBP_C PF12309.8 EFO63058.1 - 1e-97 327.9 13.0 1.4e-97 327.5 13.0 1.2 1 0 0 1 1 1 1 KIF-1 binding protein C terminal DUF2205 PF10224.9 EFO63058.1 - 0.05 13.6 0.0 0.28 11.2 0.0 2.3 1 0 0 1 1 1 0 Short coiled-coil protein His_Phos_2 PF00328.22 EFO63059.1 - 4.7e-12 45.9 0.0 2.2e-06 27.3 0.0 2.2 1 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) XRN_N PF03159.18 EFO63060.1 - 1.5e-85 286.5 0.0 2.4e-85 285.9 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EFO63060.1 - 4.1e-67 227.1 4.9 4.4e-66 223.7 4.9 2.1 1 1 0 1 1 1 1 Xrn1 helical domain ZapC PF07126.12 EFO63060.1 - 0.16 11.6 0.1 1.3 8.6 0.1 2.1 2 0 0 2 2 2 0 Cell-division protein ZapC Glyco_transf_8 PF01501.20 EFO63061.1 - 1.4e-09 37.9 2.2 7.9e-07 28.9 0.1 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 EFO63061.1 - 0.045 13.1 0.0 0.21 10.9 0.0 2.0 2 0 0 2 2 2 0 Mannosyltransferase putative Utp11 PF03998.13 EFO63063.1 - 0.00023 21.2 5.4 0.0043 17.0 4.6 2.3 2 0 0 2 2 2 1 Utp11 protein AAA_23 PF13476.6 EFO63063.1 - 0.59 10.6 13.0 1 9.8 12.6 1.5 1 1 0 1 1 1 0 AAA domain TauE PF01925.19 EFO63064.1 - 1.7e-24 86.8 25.0 5.7e-14 52.3 1.4 2.6 2 1 0 2 2 2 2 Sulfite exporter TauE/SafE Pkinase PF00069.25 EFO63066.1 - 3.2e-49 167.7 0.0 4.4e-49 167.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63066.1 - 6.4e-17 61.7 0.0 1e-16 61.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFO63066.1 - 0.02 14.8 0.0 0.041 13.8 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Glycos_transf_2 PF00535.26 EFO63066.1 - 0.021 14.7 0.0 0.042 13.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 Mcm10 PF09332.11 EFO63066.1 - 0.7 9.2 5.2 1.3 8.4 5.2 1.3 1 0 0 1 1 1 0 Mcm10 replication factor Ank_2 PF12796.7 EFO63067.1 - 2.3e-21 76.2 1.7 6.2e-07 29.9 0.2 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EFO63067.1 - 1.8e-13 50.2 2.0 0.013 15.9 0.0 5.0 4 1 1 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EFO63067.1 - 1.3e-11 44.5 2.9 0.0036 17.6 0.1 3.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63067.1 - 1.6e-09 38.1 2.7 0.03 14.9 0.1 3.4 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63067.1 - 1.5e-08 34.2 0.9 0.23 12.1 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat IQ PF00612.27 EFO63068.1 - 1.4e-05 24.5 0.6 2.6e-05 23.6 0.6 1.5 1 0 0 1 1 1 1 IQ calmodulin-binding motif VID27 PF08553.10 EFO63069.1 - 1.6e-20 73.5 0.0 1e-19 70.8 0.0 2.2 2 1 0 2 2 2 1 VID27 C-terminal WD40-like domain Leu_zip PF15294.6 EFO63069.1 - 0.24 10.9 0.1 0.4 10.1 0.1 1.2 1 0 0 1 1 1 0 Leucine zipper EF-hand_1 PF00036.32 EFO63070.1 - 1.5e-06 27.3 0.2 1.1e-05 24.7 0.0 2.6 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 EFO63070.1 - 1.4e-05 25.4 0.1 8.8e-05 22.9 0.0 2.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EFO63070.1 - 1.7e-05 24.4 0.0 0.00016 21.3 0.0 2.7 4 0 0 4 4 4 1 EF-hand domain EF-hand_5 PF13202.6 EFO63070.1 - 0.00034 20.0 0.1 0.0019 17.6 0.0 2.3 2 0 0 2 2 2 1 EF hand Glyco_trans_1_4 PF13692.6 EFO63070.1 - 0.004 17.6 0.0 0.0087 16.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 EF-hand_8 PF13833.6 EFO63070.1 - 0.012 15.4 0.9 1.4 8.8 0.0 3.8 4 0 0 4 4 4 0 EF-hand domain pair EF-hand_4 PF12763.7 EFO63070.1 - 0.071 13.1 0.0 0.46 10.5 0.0 2.1 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand Thioredoxin PF00085.20 EFO63071.1 - 3.9e-31 107.1 0.1 2.9e-30 104.3 0.1 2.2 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_6 PF13848.6 EFO63071.1 - 1.2e-22 80.7 0.6 8.8e-20 71.4 0.6 2.3 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFO63071.1 - 0.0011 19.2 0.5 3.9 7.9 0.0 3.5 2 1 1 3 3 3 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EFO63071.1 - 0.0016 18.8 0.3 0.02 15.4 0.1 2.7 2 1 0 2 2 2 1 Thioredoxin-like domain TMEM51 PF15345.6 EFO63071.1 - 0.01 15.7 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 Thioredoxin_7 PF13899.6 EFO63071.1 - 0.016 15.4 0.0 0.049 13.8 0.0 1.8 1 0 0 1 1 1 0 Thioredoxin-like Shisa PF13908.6 EFO63071.1 - 0.023 14.9 0.0 0.039 14.2 0.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator RNA_pol_Rpb5_C PF01191.19 EFO63071.1 - 0.14 12.0 0.0 0.41 10.6 0.0 1.7 1 0 0 1 1 1 0 RNA polymerase Rpb5, C-terminal domain Snapin_Pallidin PF14712.6 EFO63073.1 - 0.0026 18.2 4.7 0.11 12.9 3.4 2.5 2 0 0 2 2 2 2 Snapin/Pallidin DUF4140 PF13600.6 EFO63073.1 - 3.4 8.2 8.1 6.1 7.3 3.0 2.8 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF3712 PF12505.8 EFO63074.1 - 0.023 15.0 0.3 7 6.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3712) DUF16 PF01519.16 EFO63075.1 - 0.32 11.5 7.1 0.65 10.5 0.9 2.8 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF4446 PF14584.6 EFO63075.1 - 4.4 7.3 7.1 11 6.0 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Pkinase PF00069.25 EFO63076.1 - 7e-62 209.2 0.0 3.5e-61 206.9 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63076.1 - 1e-37 129.9 0.0 2e-37 128.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO63076.1 - 6.6e-25 87.5 0.2 2.8e-08 34.2 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63076.1 - 8.6e-16 58.1 0.0 0.0011 19.5 0.0 4.5 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63076.1 - 2.4e-13 49.0 0.0 0.41 11.4 0.0 6.0 6 0 0 6 6 5 4 Ankyrin repeat Ank_5 PF13857.6 EFO63076.1 - 9.6e-12 44.9 0.6 0.00075 19.8 0.0 4.4 1 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO63076.1 - 2.3e-10 40.4 0.6 0.6 10.7 0.0 6.3 5 1 1 6 6 6 3 Ankyrin repeat Kinase-like PF14531.6 EFO63076.1 - 3e-05 23.5 0.0 0.2 11.0 0.0 2.5 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EFO63076.1 - 0.0031 17.5 0.0 0.044 13.7 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family DUF536 PF04394.14 EFO63076.1 - 0.0055 16.5 1.8 0.014 15.2 1.8 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF536 Pkinase_fungal PF17667.1 EFO63076.1 - 0.018 13.9 0.0 0.038 12.8 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase ALMT PF11744.8 EFO63076.1 - 0.27 10.0 1.0 0.38 9.5 1.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Pkinase PF00069.25 EFO63077.1 - 3.8e-52 177.3 0.0 5e-52 176.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63077.1 - 4.7e-26 91.6 0.0 6.4e-26 91.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFO63077.1 - 0.0022 17.4 0.0 0.0038 16.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFO63077.1 - 0.013 14.8 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EFO63077.1 - 0.075 12.9 0.0 0.91 9.4 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EFO63077.1 - 0.13 11.2 0.1 0.19 10.6 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase VSP PF03302.13 EFO63078.1 - 7.8e-21 74.4 204.1 2.8e-08 33.0 8.7 7.8 1 1 4 5 5 5 5 Giardia variant-specific surface protein Ank_2 PF12796.7 EFO63079.1 - 1.1e-13 51.6 3.6 1.2e-06 29.0 0.2 4.0 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63079.1 - 1.5e-07 31.5 1.5 0.38 11.1 0.0 4.6 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO63079.1 - 2.3e-07 31.0 3.5 0.24 11.9 0.0 5.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EFO63079.1 - 1.3e-05 25.1 9.3 2.1 9.2 0.2 5.8 7 0 0 7 7 7 2 Ankyrin repeat Ank_4 PF13637.6 EFO63079.1 - 2.7e-05 24.6 2.2 0.0072 16.9 0.9 4.1 2 1 2 4 4 4 2 Ankyrin repeats (many copies) HMG_box PF00505.19 EFO63081.1 - 7.8e-08 32.6 4.3 7.8e-08 32.6 4.3 3.5 1 1 2 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFO63081.1 - 0.0064 17.1 1.9 0.0064 17.1 1.9 3.1 1 1 3 4 4 4 1 HMG-box domain Arg_decarbox_C PF17944.1 EFO63081.1 - 0.016 15.7 0.1 0.19 12.3 0.1 2.4 2 0 0 2 2 2 0 Arginine decarboxylase C-terminal helical extension DAHP_synth_2 PF01474.16 EFO63081.1 - 0.026 13.0 0.1 0.028 12.9 0.1 1.1 1 0 0 1 1 1 0 Class-II DAHP synthetase family DUF4711 PF15829.5 EFO63081.1 - 0.11 12.4 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4711) DUF3106 PF11304.8 EFO63081.1 - 0.27 11.7 9.3 1.3 9.6 0.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3106) DUF1289 PF06945.13 EFO63081.1 - 1.1 9.1 4.0 25 4.8 0.1 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF1289) HIP1_clath_bdg PF16515.5 EFO63083.1 - 0.0055 17.3 6.3 0.0076 16.8 6.3 1.2 1 0 0 1 1 1 1 Clathrin-binding domain of Huntingtin-interacting protein 1 AAA_13 PF13166.6 EFO63083.1 - 0.021 13.5 0.8 0.025 13.2 0.8 1.0 1 0 0 1 1 1 0 AAA domain DUF1160 PF06648.11 EFO63083.1 - 0.051 13.6 1.0 0.49 10.4 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1160) PsbP PF01789.16 EFO63083.1 - 0.064 13.4 0.1 0.078 13.1 0.1 1.1 1 0 0 1 1 1 0 PsbP BLOC1_2 PF10046.9 EFO63083.1 - 0.1 12.9 3.7 1.1 9.6 3.7 2.2 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SpoIIID PF12116.8 EFO63083.1 - 0.11 12.6 0.3 6.1 7.0 0.0 2.3 1 1 1 2 2 2 0 Stage III sporulation protein D Peptidase_M22 PF00814.25 EFO63084.1 - 2.5e-73 247.1 0.0 1.9e-48 165.5 0.1 2.0 2 0 0 2 2 2 2 Glycoprotease family Lactamase_B_2 PF12706.7 EFO63087.1 - 0.0013 18.3 0.1 0.005 16.4 0.0 1.8 1 1 0 2 2 2 1 Beta-lactamase superfamily domain Flavodoxin_1 PF00258.25 EFO63087.1 - 0.0019 18.5 0.0 0.003 17.8 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin Lactamase_B PF00753.27 EFO63087.1 - 0.015 15.3 0.0 0.027 14.5 0.0 1.4 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Corona_NS8 PF12093.8 EFO63087.1 - 0.13 12.9 0.3 0.33 11.5 0.3 1.7 1 0 0 1 1 1 0 Coronavirus NS8 protein AAA PF00004.29 EFO63088.1 - 1.3e-32 113.0 0.0 2.7e-32 112.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 EFO63088.1 - 0.00015 21.9 0.0 0.00057 20.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_lid_3 PF17862.1 EFO63088.1 - 0.00026 20.7 0.0 0.00061 19.5 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 EFO63088.1 - 0.0015 18.5 0.0 0.0041 17.1 0.0 1.8 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 EFO63088.1 - 0.0032 17.2 0.0 0.018 14.8 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFO63088.1 - 0.0043 17.3 0.0 0.013 15.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFO63088.1 - 0.0045 17.1 0.3 0.01 16.0 0.0 1.8 2 0 0 2 2 1 1 AAA domain TIP49 PF06068.13 EFO63088.1 - 0.0059 15.9 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 EFO63088.1 - 0.0074 16.7 0.6 0.035 14.5 0.6 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EFO63088.1 - 0.012 15.7 0.0 0.05 13.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFO63088.1 - 0.029 14.9 0.0 0.2 12.2 0.0 2.5 3 0 0 3 3 2 0 AAA domain NACHT PF05729.12 EFO63088.1 - 0.051 13.5 0.1 0.35 10.8 0.0 2.2 1 1 1 2 2 2 0 NACHT domain AAA_5 PF07728.14 EFO63088.1 - 0.091 12.8 0.0 0.36 10.8 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EFO63088.1 - 0.093 13.1 0.0 0.33 11.4 0.0 2.0 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 EFO63088.1 - 0.098 12.0 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EFO63088.1 - 0.1 12.3 0.1 0.24 11.1 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EFO63088.1 - 0.19 12.0 0.8 0.73 10.1 0.2 2.3 2 1 0 2 2 2 0 AAA domain DEAD PF00270.29 EFO63089.1 - 3.1e-45 154.1 0.0 7.5e-45 152.8 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO63089.1 - 3.2e-28 98.3 0.1 6.7e-27 94.0 0.1 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EFO63089.1 - 0.00041 19.6 0.0 0.0012 18.1 0.0 1.9 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Lact-deh-memb PF09330.11 EFO63089.1 - 0.0014 18.1 0.9 0.0022 17.4 0.9 1.3 1 0 0 1 1 1 1 D-lactate dehydrogenase, membrane binding ResIII PF04851.15 EFO63089.1 - 0.006 16.6 0.0 0.029 14.4 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SET PF00856.28 EFO63090.1 - 0.19 12.1 0.2 0.51 10.7 0.0 2.0 2 0 0 2 2 2 0 SET domain Methyltransf_23 PF13489.6 EFO63092.1 - 4.4e-20 72.2 0.0 1e-19 71.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFO63092.1 - 7.5e-12 45.7 0.0 1.6e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFO63092.1 - 2.5e-10 41.0 0.0 6.7e-10 39.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFO63092.1 - 3.6e-10 39.8 0.1 2e-08 34.2 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFO63092.1 - 3.6e-09 37.2 0.0 2.8e-08 34.3 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EFO63092.1 - 0.0014 18.3 0.0 0.0034 17.0 0.0 1.6 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Ubie_methyltran PF01209.18 EFO63092.1 - 0.0053 16.1 0.0 0.017 14.5 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family UVR PF02151.19 EFO63092.1 - 0.21 11.4 0.4 0.44 10.4 0.4 1.6 1 0 0 1 1 1 0 UvrB/uvrC motif DUF5531 PF17671.1 EFO63093.1 - 0.15 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5531) MORN PF02493.20 EFO63094.1 - 4.7e-27 92.2 36.1 1.6e-05 24.5 2.3 7.4 8 0 0 8 8 8 6 MORN repeat SDA1 PF05285.12 EFO63094.1 - 0.022 14.2 5.4 0.03 13.8 5.4 1.1 1 0 0 1 1 1 0 SDA1 NHL PF01436.21 EFO63094.1 - 0.18 11.9 0.0 0.38 10.9 0.0 1.5 1 0 0 1 1 1 0 NHL repeat CDC45 PF02724.14 EFO63094.1 - 0.66 8.2 7.1 0.82 7.9 7.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Merozoite_SPAM PF07133.11 EFO63094.1 - 0.95 9.4 18.6 1.3 9.0 18.6 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) RRN3 PF05327.11 EFO63094.1 - 8.7 4.7 6.8 11 4.4 6.8 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SR-25 PF10500.9 EFO63096.1 - 0.0032 17.1 4.8 0.0032 17.1 4.8 4.8 3 1 1 4 4 4 1 Nuclear RNA-splicing-associated protein FTCD_C PF04961.12 EFO63096.1 - 0.017 14.9 0.2 0.035 13.9 0.2 1.5 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase Thioredoxin_7 PF13899.6 EFO63097.1 - 0.0034 17.5 0.0 0.0064 16.7 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like Rab5ip PF07019.12 EFO63099.1 - 0.00014 22.3 8.3 0.00047 20.7 8.3 1.8 1 1 0 1 1 1 1 Rab5-interacting protein (Rab5ip) Acetyltransf_1 PF00583.25 EFO63100.1 - 1.2e-10 41.7 0.0 1.5e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFO63100.1 - 8.2e-05 23.0 0.0 0.00012 22.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFO63100.1 - 0.0017 18.3 0.0 0.0034 17.3 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFO63100.1 - 0.024 14.6 0.0 0.044 13.7 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein DnaJ PF00226.31 EFO63102.1 - 5.9e-17 61.5 0.3 5.9e-17 61.5 0.3 2.2 2 0 0 2 2 1 1 DnaJ domain zf-C2H2_2 PF12756.7 EFO63102.1 - 7e-07 29.5 8.5 0.0011 19.3 0.3 2.8 3 0 0 3 3 2 2 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 EFO63102.1 - 8.5e-07 29.2 10.4 1.6e-06 28.3 2.0 2.9 3 0 0 3 3 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EFO63102.1 - 0.00019 21.6 3.1 0.00019 21.6 3.1 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EFO63102.1 - 0.00021 21.8 6.5 0.03 15.2 0.8 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EFO63102.1 - 0.01 16.2 9.6 0.065 13.7 1.7 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EFO63102.1 - 0.025 14.6 7.5 0.14 12.2 0.6 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-DBF PF07535.12 EFO63102.1 - 0.041 14.0 6.1 0.064 13.4 0.6 2.6 2 0 0 2 2 2 0 DBF zinc finger DUF4574 PF15141.6 EFO63102.1 - 0.85 9.6 5.2 1.4 8.9 0.0 2.5 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 GvpL_GvpF PF06386.11 EFO63102.1 - 1.3 8.8 9.7 3.4 7.5 9.7 1.6 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Elf1 PF05129.13 EFO63102.1 - 4.6 7.4 8.0 4.3 7.5 0.0 3.1 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like zf-met2 PF12907.7 EFO63102.1 - 4.6 7.5 7.1 15 5.9 0.4 2.7 2 0 0 2 2 2 0 Zinc-binding HMG_box_2 PF09011.10 EFO63102.1 - 5 7.8 11.1 0.63 10.7 0.9 3.4 2 2 0 3 3 3 0 HMG-box domain LSM PF01423.22 EFO63103.1 - 4.9e-13 48.6 0.1 6.2e-13 48.2 0.1 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFO63103.1 - 0.023 14.9 0.1 0.031 14.4 0.1 1.3 1 1 0 1 1 1 0 Ataxin 2 SM domain FAM104 PF15434.6 EFO63103.1 - 0.081 13.5 1.1 0.11 13.0 1.1 1.2 1 0 0 1 1 1 0 Family 104 SET PF00856.28 EFO63104.1 - 0.00011 22.7 0.1 0.00021 21.7 0.0 1.6 2 0 0 2 2 2 1 SET domain Prok-RING_1 PF14446.6 EFO63104.1 - 0.4 10.7 7.8 1 9.3 7.8 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-MYND PF01753.18 EFO63104.1 - 0.45 10.7 15.3 0.033 14.3 9.0 2.1 2 0 0 2 2 2 0 MYND finger HypA PF01155.19 EFO63104.1 - 1.6 8.8 5.7 0.49 10.4 2.4 1.7 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA XRN_N PF03159.18 EFO63105.1 - 2.2e-64 217.2 0.0 3.8e-64 216.4 0.0 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EFO63105.1 - 2.3e-15 56.5 4.2 5.8e-09 35.4 0.1 2.2 2 0 0 2 2 2 2 Xrn1 helical domain Methyltransf_16 PF10294.9 EFO63106.1 - 3.7e-14 52.9 0.0 3.2e-13 49.8 0.0 2.2 2 1 0 2 2 2 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EFO63106.1 - 0.0009 19.1 0.0 0.0019 18.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFO63106.1 - 0.036 13.6 0.0 0.073 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_12 PF08242.12 EFO63106.1 - 0.049 14.4 0.0 0.49 11.2 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EFO63106.1 - 0.065 12.4 0.0 0.81 8.8 0.0 2.1 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family Methyltransf_25 PF13649.6 EFO63106.1 - 0.15 12.8 0.0 0.29 11.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Kinesin PF00225.23 EFO63107.1 - 1.6e-79 267.2 0.1 1.6e-79 267.2 0.1 1.6 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFO63107.1 - 2.1e-17 63.4 0.2 6.9e-17 61.8 0.0 2.0 2 1 0 2 2 2 1 Microtubule binding End3 PF12761.7 EFO63107.1 - 0.0046 17.2 8.3 0.011 15.9 8.3 1.6 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 DUF2508 PF10704.9 EFO63107.1 - 0.063 13.5 10.8 0.17 12.1 1.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) eIF3_N PF09440.10 EFO63107.1 - 0.17 12.3 4.2 0.47 10.9 4.2 1.8 1 0 0 1 1 1 0 eIF3 subunit 6 N terminal domain BLOC1_2 PF10046.9 EFO63107.1 - 0.85 10.0 10.0 4.8 7.5 2.6 3.3 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CLZ PF16526.5 EFO63107.1 - 1.5 9.2 8.8 0.76 10.2 1.3 3.1 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ACCA PF03255.14 EFO63107.1 - 2.1 8.2 6.2 3.5 7.5 0.7 2.5 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit TSC22 PF01166.18 EFO63107.1 - 2.4 8.5 5.6 11 6.4 0.3 3.5 4 0 0 4 4 4 0 TSC-22/dip/bun family DUF745 PF05335.13 EFO63107.1 - 3 7.5 11.2 8.8 6.0 11.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Ank_2 PF12796.7 EFO63108.1 - 3.6e-67 222.9 5.8 1.6e-15 57.5 0.1 5.3 1 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.30 EFO63108.1 - 4.4e-37 124.9 0.0 0.0028 18.0 0.0 10.2 10 0 0 10 10 10 9 Ankyrin repeat Ank_3 PF13606.6 EFO63108.1 - 1.2e-33 111.3 0.3 0.19 12.4 0.0 10.2 10 0 0 10 10 10 10 Ankyrin repeat Ank_4 PF13637.6 EFO63108.1 - 3.5e-31 107.2 2.1 0.00028 21.4 0.0 8.0 4 2 5 9 9 9 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO63108.1 - 1.9e-29 101.3 2.9 3.6e-05 24.0 0.0 8.9 2 1 7 9 9 9 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFO63109.1 - 1.3e-83 275.7 23.1 7.7e-12 45.6 0.0 9.7 4 3 4 9 9 9 9 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO63109.1 - 7.3e-55 186.2 0.0 1.1e-54 185.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ank_5 PF13857.6 EFO63109.1 - 1.6e-47 158.9 21.5 4.5e-05 23.7 0.0 13.6 7 3 7 15 15 15 11 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63109.1 - 3.1e-38 129.7 22.0 2.4e-06 28.0 0.0 12.8 8 4 7 15 15 15 11 Ankyrin repeats (many copies) Ank PF00023.30 EFO63109.1 - 1.6e-34 116.9 21.0 0.0093 16.4 0.0 14.6 15 1 1 16 16 16 10 Ankyrin repeat Pkinase_Tyr PF07714.17 EFO63109.1 - 6.5e-33 114.1 0.0 1e-32 113.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_3 PF13606.6 EFO63109.1 - 1.8e-31 104.6 16.9 0.033 14.7 0.0 14.4 16 0 0 16 16 16 9 Ankyrin repeat VWA_3_C PF18571.1 EFO63109.1 - 0.079 12.8 4.7 3.3 7.6 0.0 4.4 5 0 0 5 5 5 0 von Willebrand factor type A C-terminal domain APH PF01636.23 EFO63109.1 - 0.086 12.7 0.0 0.99 9.3 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family HORMA PF02301.18 EFO63110.1 - 1.5e-17 63.9 0.0 4.1e-17 62.5 0.0 1.6 1 1 0 1 1 1 1 HORMA domain Arcadin_1 PF18653.1 EFO63110.1 - 0.0046 17.0 0.0 0.0073 16.4 0.0 1.4 1 0 0 1 1 1 1 Arcadin 1 Methyltransf_16 PF10294.9 EFO63111.1 - 1e-19 70.9 0.1 1.3e-19 70.6 0.1 1.1 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EFO63111.1 - 2.9e-05 23.6 0.2 3.9e-05 23.2 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) GidB PF02527.15 EFO63111.1 - 0.0041 16.5 0.0 0.0063 15.9 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_12 PF08242.12 EFO63111.1 - 0.029 15.1 0.1 0.047 14.4 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain EF-hand_1 PF00036.32 EFO63112.1 - 4.9e-16 57.0 0.4 4.1e-07 29.1 0.0 3.8 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 EFO63112.1 - 2.2e-14 52.1 2.5 4.2e-06 26.3 0.0 4.2 4 1 1 5 5 5 2 EF-hand domain EF-hand_7 PF13499.6 EFO63112.1 - 3.5e-14 53.0 0.5 4.6e-06 27.0 0.0 2.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EFO63112.1 - 7.6e-11 41.0 0.1 0.00086 18.7 0.0 3.5 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 EFO63112.1 - 6.7e-10 38.7 0.2 0.0028 17.4 0.0 3.8 3 1 2 5 5 5 3 EF-hand domain pair EF-hand_9 PF14658.6 EFO63112.1 - 0.00035 20.8 0.1 0.45 10.9 0.0 3.0 2 2 0 2 2 2 2 EF-hand domain EF-hand_14 PF17959.1 EFO63112.1 - 0.0026 18.1 0.1 0.043 14.2 0.1 2.7 1 1 1 2 2 2 1 EF-hand domain Adeno_E3A PF05248.12 EFO63112.1 - 0.13 12.3 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Adenovirus E3A HSP70 PF00012.20 EFO63113.1 - 1.3e-54 185.5 5.1 7.6e-52 176.3 5.1 2.2 1 1 0 1 1 1 1 Hsp70 protein Ribosomal_L6 PF00347.23 EFO63113.1 - 0.068 13.8 1.1 0.22 12.2 1.1 1.8 1 0 0 1 1 1 0 Ribosomal protein L6 DUF1154 PF06631.11 EFO63113.1 - 0.12 12.4 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1154) Tox-HNH-EHHH PF15657.6 EFO63113.1 - 0.45 10.9 0.1 0.45 10.9 0.1 1.9 2 0 0 2 2 2 0 HNH/Endo VII superfamily nuclease toxins DUF3987 PF13148.6 EFO63113.1 - 2.5 7.0 9.6 0.46 9.4 5.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Phage_Mu_Gam PF07352.12 EFO63113.1 - 5 7.0 14.7 0.72 9.7 7.3 2.9 3 0 0 3 3 3 0 Bacteriophage Mu Gam like protein Laminin_I PF06008.14 EFO63113.1 - 7.6 6.2 18.7 0.47 10.1 7.0 3.1 1 1 0 2 2 2 0 Laminin Domain I LSM PF01423.22 EFO63114.1 - 1.4e-08 34.3 0.0 1.9e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 LSM domain DUF4444 PF14563.6 EFO63114.1 - 0.11 12.1 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4444) VSP PF03302.13 EFO63115.1 - 2.3e-42 145.3 196.0 5.9e-29 101.1 78.8 7.0 1 1 3 4 4 4 4 Giardia variant-specific surface protein DUF4705 PF15788.5 EFO63115.1 - 0.37 11.1 4.6 1.1 9.6 4.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4705) Peptidase_C1 PF00112.23 EFO63116.1 - 5.3e-30 105.1 0.4 2.4e-29 103.0 0.4 2.0 1 1 0 1 1 1 1 Papain family cysteine protease Peptidase_C39_2 PF13529.6 EFO63116.1 - 0.00041 20.9 0.3 0.00084 19.9 0.0 1.7 2 0 0 2 2 2 1 Peptidase_C39 like family Peptidase_C1_2 PF03051.15 EFO63116.1 - 0.00063 18.6 0.1 0.0013 17.6 0.1 1.4 1 0 0 1 1 1 1 Peptidase C1-like family DUF4448 PF14610.6 EFO63116.1 - 0.014 15.1 0.0 0.036 13.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) OAD_gamma PF04277.13 EFO63116.1 - 0.053 14.1 0.0 0.1 13.2 0.0 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Peptidase_C1 PF00112.23 EFO63117.1 - 6.9e-54 183.2 0.4 1.1e-53 182.6 0.4 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFO63117.1 - 0.018 13.8 1.6 0.45 9.2 0.4 2.1 2 0 0 2 2 2 0 Peptidase C1-like family Peptidase_C1 PF00112.23 EFO63118.1 - 3.4e-52 177.7 0.0 5e-52 177.1 0.0 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFO63118.1 - 0.11 11.3 0.7 1.2 7.8 0.1 2.1 2 0 0 2 2 2 0 Peptidase C1-like family Ras PF00071.22 EFO63119.1 - 8.3e-59 197.8 1.1 9.9e-59 197.6 1.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFO63119.1 - 1.3e-33 115.8 0.8 1.3e-33 115.8 0.8 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFO63119.1 - 5.4e-17 61.8 0.1 6.6e-17 61.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFO63119.1 - 7.3e-07 29.3 0.3 1.5e-06 28.2 0.2 1.6 1 1 1 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFO63119.1 - 7.3e-06 25.5 0.3 8.6e-06 25.3 0.3 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFO63119.1 - 0.0011 18.9 0.7 0.085 12.8 0.0 2.4 1 1 2 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 EFO63119.1 - 0.0015 18.1 1.2 0.017 14.7 1.2 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EFO63119.1 - 0.0019 17.7 0.1 0.0027 17.2 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Septin PF00735.18 EFO63119.1 - 0.0043 16.4 0.3 0.01 15.1 0.0 1.7 2 1 0 2 2 2 1 Septin AAA_16 PF13191.6 EFO63119.1 - 0.0045 17.4 0.0 0.0056 17.1 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain FeoB_N PF02421.18 EFO63119.1 - 0.0082 15.7 0.1 0.68 9.5 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_5 PF07728.14 EFO63119.1 - 0.025 14.6 0.0 0.047 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFO63119.1 - 0.026 14.8 0.0 0.061 13.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain MCM PF00493.23 EFO63119.1 - 0.029 13.5 0.0 0.066 12.3 0.0 1.5 1 1 0 1 1 1 0 MCM P-loop domain AAA_29 PF13555.6 EFO63119.1 - 0.059 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 EFO63119.1 - 0.068 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 EFO63119.1 - 0.082 13.3 0.1 0.16 12.4 0.1 1.7 1 1 0 1 1 1 0 RNA helicase NusB PF01029.18 EFO63121.1 - 0.043 14.0 0.0 0.058 13.6 0.0 1.2 1 0 0 1 1 1 0 NusB family Ligase_CoA PF00549.19 EFO63121.1 - 0.14 12.0 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 CoA-ligase Sec63 PF02889.16 EFO63122.1 - 1.6e-77 260.2 7.6 1.8e-46 158.4 0.3 2.9 2 1 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EFO63122.1 - 5.7e-44 150.0 1.1 1e-22 80.8 0.2 3.7 4 0 0 4 4 4 2 DEAD/DEAH box helicase ResIII PF04851.15 EFO63122.1 - 1.9e-18 67.0 0.0 5.1e-10 39.6 0.0 3.5 3 1 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFO63122.1 - 3.5e-15 56.3 1.2 2.1e-06 28.0 0.0 3.9 3 1 0 3 3 3 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 EFO63122.1 - 2e-05 24.9 0.3 1 9.6 0.1 4.4 3 1 0 3 3 3 2 AAA domain AAA_7 PF12775.7 EFO63122.1 - 0.0041 16.6 0.4 1.2 8.7 0.0 3.1 3 0 0 3 3 3 2 P-loop containing dynein motor region T2SSE PF00437.20 EFO63122.1 - 0.0058 15.7 0.0 1.1 8.2 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein PUF PF00806.19 EFO63123.1 - 0.06 13.1 0.2 0.44 10.3 0.0 2.6 2 0 0 2 2 2 0 Pumilio-family RNA binding repeat BBP1_N PF15271.6 EFO63125.1 - 3.4 8.5 10.3 1.2 9.9 3.5 3.2 3 0 0 3 3 3 0 Spindle pole body component BBP1, Mps2-binding protein pP_pnuc_1 PF18165.1 EFO63126.1 - 0.019 14.8 0.0 0.024 14.5 0.0 1.1 1 0 0 1 1 1 0 Predicted pPIWI-associating nuclease EptA_B_N PF08019.12 EFO63128.1 - 0.034 14.0 0.7 0.13 12.1 0.2 2.0 2 0 0 2 2 2 0 Phosphoethanolamine transferase EptA/EptB Lipase_chap PF03280.14 EFO63128.1 - 0.13 12.2 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Proteobacterial lipase chaperone protein Pam16 PF03656.13 EFO63130.1 - 0.062 13.3 0.1 0.13 12.3 0.1 1.5 1 1 0 1 1 1 0 Pam16 Glyco_hydro_108 PF05838.12 EFO63130.1 - 0.17 12.4 0.0 0.28 11.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase 108 G6PD_C PF02781.16 EFO63133.1 - 4.1e-68 229.7 0.0 6.2e-68 229.1 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 EFO63133.1 - 5.7e-45 154.1 0.0 1e-44 153.3 0.0 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Glucosamine_iso PF01182.20 EFO63133.1 - 2.3e-26 93.0 0.0 3.8e-26 92.4 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 6PGD PF00393.19 EFO63134.1 - 1.1e-83 280.9 0.1 1.8e-83 280.3 0.1 1.3 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EFO63134.1 - 1.3e-35 122.9 0.0 2.7e-35 121.9 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EFO63134.1 - 3.7e-08 33.8 0.3 7.4e-08 32.9 0.3 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EFO63134.1 - 4.4e-08 33.3 0.2 2.2e-07 31.0 0.3 2.1 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EFO63134.1 - 6.7e-05 22.3 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EFO63134.1 - 7.6e-05 22.7 0.1 0.00059 19.8 0.1 2.1 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EFO63134.1 - 0.00029 21.7 0.1 0.0025 18.6 0.1 2.2 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold IlvN PF07991.12 EFO63134.1 - 0.0003 20.4 0.7 0.0017 17.9 0.3 2.5 2 1 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_Gly3P_dh_N PF01210.23 EFO63134.1 - 0.00067 19.7 0.0 0.0015 18.5 0.0 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Sacchrp_dh_NADP PF03435.18 EFO63134.1 - 0.0017 18.6 0.1 0.0037 17.5 0.1 1.6 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 EFO63134.1 - 0.017 14.8 0.1 0.036 13.7 0.1 1.6 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA HHH_6 PF14579.6 EFO63134.1 - 0.071 13.4 0.0 0.22 11.8 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif CoA_binding PF02629.19 EFO63134.1 - 0.092 13.4 0.1 0.7 10.6 0.1 2.3 2 0 0 2 2 2 0 CoA binding domain EGF_2 PF07974.13 EFO63135.1 - 6.1e-24 84.1 161.6 0.00034 20.9 8.6 12.0 11 1 1 12 12 12 10 EGF-like domain EGF PF00008.27 EFO63135.1 - 1.7e-06 28.2 33.7 0.00024 21.3 7.4 13.0 11 4 1 12 12 12 6 EGF-like domain hEGF PF12661.7 EFO63135.1 - 0.00023 21.6 22.6 0.00028 21.4 8.2 14.3 16 0 0 16 16 16 5 Human growth factor-like EGF Laminin_EGF PF00053.24 EFO63135.1 - 0.011 15.8 12.4 0.011 15.8 12.4 10.2 4 3 5 9 9 9 0 Laminin EGF domain GCD14 PF08704.10 EFO63137.1 - 4.3e-51 174.0 0.0 7.5e-51 173.2 0.0 1.4 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 EFO63137.1 - 0.0018 18.1 0.0 0.0044 16.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain GCD14_N PF14801.6 EFO63137.1 - 0.0057 16.5 0.1 0.024 14.4 0.0 2.1 2 0 0 2 2 2 1 tRNA methyltransferase complex GCD14 subunit N-term Methyltransf_25 PF13649.6 EFO63137.1 - 0.02 15.6 0.0 0.061 14.0 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 EFO63137.1 - 0.03 15.0 0.0 0.073 13.7 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain CBS PF00571.28 EFO63138.1 - 6e-09 36.2 0.4 0.02 15.3 0.0 3.7 3 1 0 3 3 3 2 CBS domain DUF3541 PF12060.8 EFO63138.1 - 0.094 12.4 0.1 0.17 11.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3541) tRNA-synt_2c PF01411.19 EFO63139.1 - 1.4e-57 195.4 0.0 2.3e-25 89.1 0.0 3.1 2 1 1 3 3 3 3 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EFO63139.1 - 1.6e-11 44.1 1.5 3.6e-11 43.0 1.5 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain zf-UDP PF14569.6 EFO63139.1 - 0.3 11.2 2.2 7.9 6.7 0.0 2.5 2 0 0 2 2 2 0 Zinc-binding RING-finger zinc_ribbon_2 PF13240.6 EFO63139.1 - 2.2 8.1 4.2 23 4.9 0.3 2.9 3 0 0 3 3 3 0 zinc-ribbon domain Pyr_redox_2 PF07992.14 EFO63140.1 - 0.023 14.0 0.0 0.36 10.0 0.0 2.1 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DNA_processg_A PF02481.15 EFO63140.1 - 0.11 11.7 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 DNA recombination-mediator protein A RNA_pol_Rpb5_C PF01191.19 EFO63141.1 - 6.4e-26 90.0 0.1 1.2e-25 89.1 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EFO63141.1 - 4.1e-06 27.3 0.4 1.1e-05 25.9 0.4 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain VSP PF03302.13 EFO63142.1 - 8.4e-65 219.1 138.5 3.9e-47 161.0 25.4 4.2 1 1 3 4 4 4 2 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO63142.1 - 3.3 7.8 5.3 1.2 9.2 1.5 2.1 2 1 1 3 3 3 0 Podoplanin TPR_2 PF07719.17 EFO63143.1 - 3.8e-35 117.1 11.3 0.0015 18.5 0.1 12.3 13 0 0 13 13 13 7 Tetratricopeptide repeat TPR_1 PF00515.28 EFO63143.1 - 3.9e-31 105.6 12.0 0.0001 22.0 0.1 11.2 12 0 0 12 12 11 6 Tetratricopeptide repeat TPR_12 PF13424.6 EFO63143.1 - 8.3e-22 77.3 19.1 0.0001 22.5 0.2 9.1 7 2 1 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.6 EFO63143.1 - 1.4e-21 76.8 2.0 1.1e-05 25.8 0.1 7.1 7 1 0 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFO63143.1 - 1.3e-19 68.7 17.4 0.069 13.4 0.0 11.1 12 0 0 12 12 11 5 Tetratricopeptide repeat ANAPC3 PF12895.7 EFO63143.1 - 2.1e-16 59.9 11.3 1.9e-06 28.0 0.9 6.1 4 2 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EFO63143.1 - 2.6e-14 52.7 0.3 3.7 8.6 0.0 9.9 6 3 5 11 11 9 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFO63143.1 - 8.4e-14 50.9 8.2 0.025 14.9 0.0 8.3 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFO63143.1 - 1.6e-12 47.2 10.0 0.11 13.2 0.2 9.3 11 0 0 11 11 8 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFO63143.1 - 5.5e-12 45.2 5.7 0.011 15.5 0.0 6.8 7 1 1 8 8 6 3 TPR repeat TPR_16 PF13432.6 EFO63143.1 - 1.3e-11 45.0 0.0 1.2 9.9 0.0 7.1 3 1 4 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFO63143.1 - 1e-06 28.3 10.2 0.82 9.8 0.0 9.1 11 0 0 11 11 10 1 Tetratricopeptide repeat DUF4919 PF16266.5 EFO63143.1 - 0.00028 20.9 0.1 0.0012 18.8 0.2 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4919) DUF4810 PF16068.5 EFO63143.1 - 0.0029 18.1 2.8 0.29 11.7 0.0 4.3 4 1 1 5 5 4 1 Domain of unknown function (DUF4810) TPR_10 PF13374.6 EFO63143.1 - 0.0036 17.1 12.7 1.5 8.8 0.1 8.0 10 0 0 10 10 7 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFO63143.1 - 0.0052 16.9 0.0 25 5.1 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_15 PF13429.6 EFO63143.1 - 0.014 14.6 5.5 0.062 12.5 1.1 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat Ku_PK_bind PF08785.11 EFO63143.1 - 0.021 14.9 0.1 0.16 12.1 0.0 2.4 2 0 0 2 2 2 0 Ku C terminal domain like Foie-gras_1 PF11817.8 EFO63143.1 - 0.033 13.8 2.2 0.11 12.0 0.1 2.6 2 0 0 2 2 2 0 Foie gras liver health family 1 UBN_AB PF14075.6 EFO63143.1 - 0.044 13.5 0.5 0.41 10.3 0.1 2.3 2 0 0 2 2 2 0 Ubinuclein conserved middle domain ANAPC5 PF12862.7 EFO63143.1 - 0.085 12.9 0.4 20 5.4 0.0 3.5 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 5 TPR_3 PF07720.12 EFO63143.1 - 0.085 12.9 4.5 18 5.5 0.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3856 PF12968.7 EFO63143.1 - 0.12 12.4 0.4 2.1 8.4 0.0 3.3 3 0 0 3 3 3 0 Domain of Unknown Function (DUF3856) DUF3808 PF10300.9 EFO63143.1 - 0.33 9.6 8.9 0.35 9.5 0.1 2.9 2 2 1 3 3 3 0 Protein of unknown function (DUF3808) FliJ PF02050.16 EFO63143.1 - 2.7 8.3 8.6 21 5.3 0.1 4.0 4 1 1 5 5 4 0 Flagellar FliJ protein XPG_I PF00867.18 EFO63144.1 - 5e-15 55.6 0.0 1.2e-14 54.4 0.0 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EFO63144.1 - 1.3e-05 25.6 0.0 3.4e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 EFO63144.1 - 0.00082 18.9 0.0 0.0015 18.1 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing TPR_14 PF13428.6 EFO63144.1 - 0.0028 18.3 0.2 0.0085 16.8 0.2 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFO63144.1 - 0.0067 16.6 0.2 0.017 15.3 0.2 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFO63144.1 - 0.017 15.6 0.1 0.04 14.4 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFO63144.1 - 0.036 14.1 0.1 0.089 12.9 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFO63144.1 - 0.066 13.5 0.4 0.14 12.5 0.4 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFO63144.1 - 0.15 12.0 0.1 0.29 11.0 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFO63144.1 - 0.24 11.6 1.2 0.38 11.0 0.1 1.9 2 0 0 2 2 1 0 Tetratricopeptide repeat TPR_4 PF07721.14 EFO63144.1 - 1.9 9.3 3.6 0.89 10.4 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat PCI PF01399.27 EFO63147.1 - 2.9e-07 30.9 0.8 2e-06 28.2 0.1 2.6 3 0 0 3 3 3 1 PCI domain tRNA_SAD PF07973.14 EFO63149.1 - 1.5e-08 34.6 2.4 1.5e-08 34.6 2.4 1.9 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain RNB PF00773.19 EFO63151.1 - 1.6e-89 300.4 0.0 2.7e-89 299.7 0.0 1.3 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 EFO63151.1 - 0.0016 18.4 0.0 0.0047 16.9 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PEP-utilizers_C PF02896.18 EFO63152.1 - 5.3e-85 285.1 0.3 8.7e-85 284.4 0.3 1.3 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PPDK_N PF01326.19 EFO63152.1 - 5.2e-52 177.1 0.0 3.5e-38 131.7 0.0 3.2 1 1 1 2 2 2 2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain PEP-utilizers PF00391.23 EFO63152.1 - 2.3e-24 84.9 1.3 6.3e-24 83.5 0.4 2.3 2 0 0 2 2 2 1 PEP-utilising enzyme, mobile domain Indigoidine_A PF04227.12 EFO63153.1 - 2.2e-45 155.3 0.1 2.7e-45 155.0 0.1 1.0 1 0 0 1 1 1 1 Indigoidine synthase A like protein Annexin PF00191.20 EFO63154.1 - 3.3e-10 39.9 2.8 0.00013 22.0 0.0 3.9 3 1 2 5 5 5 3 Annexin Nop52 PF05997.12 EFO63156.1 - 2.6e-33 115.7 0.0 4.8e-33 114.8 0.0 1.5 1 0 0 1 1 1 1 Nucleolar protein,Nop52 eIF2A PF08662.11 EFO63158.1 - 1.7e-11 44.3 0.0 1.8e-09 37.8 0.0 2.5 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A EF-hand_13 PF17958.1 EFO63161.1 - 1.3e-19 69.8 1.4 5e-18 64.7 0.2 3.6 2 1 1 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 EFO63161.1 - 1.1e-12 48.2 4.8 1.5e-12 47.8 0.1 3.6 3 2 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 EFO63161.1 - 8.5e-08 31.2 1.4 0.00014 21.1 0.3 3.0 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFO63161.1 - 5.6e-07 29.0 3.0 0.00014 21.5 0.1 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 EFO63161.1 - 0.00069 19.0 0.4 0.018 14.5 0.2 2.5 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EFO63161.1 - 0.11 12.3 2.2 0.56 10.1 0.6 2.6 2 0 0 2 2 2 0 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFO63161.1 - 0.21 11.9 2.4 17 5.8 0.1 2.9 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region E2F_TDP PF02319.20 EFO63167.1 - 7.6e-23 80.4 0.0 7e-11 42.0 0.0 2.6 2 1 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain B-block_TFIIIC PF04182.12 EFO63167.1 - 0.011 15.8 0.0 0.097 12.8 0.0 2.3 2 0 0 2 2 2 0 B-block binding subunit of TFIIIC Cdc6_C PF09079.11 EFO63167.1 - 0.036 14.0 0.2 0.89 9.6 0.0 2.7 3 0 0 3 3 3 0 CDC6, C terminal winged helix domain MarR_2 PF12802.7 EFO63167.1 - 0.054 13.4 0.0 0.63 10.0 0.0 2.3 2 0 0 2 2 2 0 MarR family TrmB PF01978.19 EFO63167.1 - 0.086 12.7 0.0 0.56 10.1 0.0 2.1 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Synthase_beta PF11421.8 EFO63167.1 - 0.66 10.7 0.1 0.66 10.7 0.1 3.3 3 0 0 3 3 3 0 ATP synthase F1 beta subunit DUF2017 PF09438.10 EFO63168.1 - 0.14 12.0 7.7 0.24 11.3 0.1 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF2017) Metallophos PF00149.28 EFO63169.1 - 3.6e-24 86.4 0.0 7.2e-24 85.4 0.0 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase VSP PF03302.13 EFO63170.1 - 2.4e-75 253.8 178.2 7e-71 239.2 92.9 5.9 1 1 3 5 5 5 3 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO63170.1 - 2.1e-05 24.6 19.2 2.1e-05 24.6 19.2 13.0 2 2 10 12 12 12 7 Furin-like repeat, cysteine-rich DUF4215 PF13948.6 EFO63170.1 - 0.00021 21.7 9.7 0.00021 21.7 9.7 12.4 9 4 3 12 12 12 2 Domain of unknown function (DUF4215) Fructosamin_kin PF03881.14 EFO63171.1 - 2.5e-67 227.1 0.0 2.7e-67 227.0 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 EFO63171.1 - 0.00097 19.1 0.0 0.0014 18.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family GTP_EFTU PF00009.27 EFO63172.1 - 2.7e-25 89.1 1.6 1.7e-24 86.5 1.6 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.11 EFO63172.1 - 4.8e-24 84.4 1.3 1.2e-23 83.1 1.3 1.8 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.25 EFO63172.1 - 4.4e-06 27.0 0.1 1.2e-05 25.6 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFO63172.1 - 0.00014 22.0 0.0 0.00049 20.2 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EFO63172.1 - 0.0019 18.2 0.1 0.0053 16.8 0.1 1.8 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 EFO63172.1 - 0.0033 17.3 0.1 0.082 12.8 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Arf PF00025.21 EFO63172.1 - 0.017 14.5 0.1 0.041 13.3 0.1 1.7 1 0 0 1 1 1 0 ADP-ribosylation factor family cobW PF02492.19 EFO63172.1 - 0.068 12.8 0.1 0.068 12.8 0.1 2.2 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EFO63172.1 - 0.33 9.9 4.8 0.33 9.9 0.1 2.6 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Cation_efflux PF01545.21 EFO63173.1 - 2.5e-65 219.9 7.8 3.9e-65 219.3 7.8 1.3 1 0 0 1 1 1 1 Cation efflux family Mito_morph_reg PF14972.6 EFO63173.1 - 0.065 12.8 0.2 0.15 11.6 0.2 1.6 1 0 0 1 1 1 0 Mitochondrial morphogenesis regulator Trp_oprn_chp PF09534.10 EFO63173.1 - 0.26 11.1 0.8 14 5.5 0.0 3.0 1 1 1 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Cyt-b5 PF00173.28 EFO63174.1 - 1.5e-11 44.2 0.0 4.3e-11 42.8 0.0 1.7 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DUF2340 PF10209.9 EFO63175.1 - 2.3e-17 63.5 0.0 2.8e-17 63.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) TUG-UBL1 PF11470.8 EFO63175.1 - 0.0025 18.0 0.1 0.032 14.4 0.0 2.1 2 0 0 2 2 2 1 TUG ubiquitin-like domain HSP70 PF00012.20 EFO63176.1 - 5.8e-18 64.4 0.1 2.7e-16 58.9 0.1 4.9 4 1 1 5 5 5 2 Hsp70 protein BNIP2 PF12496.8 EFO63176.1 - 0.21 12.0 11.4 0.8 10.1 4.4 3.2 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 FtsA PF14450.6 EFO63176.1 - 0.23 11.9 0.8 1.7 9.1 0.0 2.9 3 0 0 3 3 3 0 Cell division protein FtsA DIL PF01843.19 EFO63176.1 - 0.48 10.7 2.4 3.4 8.0 0.1 2.8 2 0 0 2 2 2 0 DIL domain IL15 PF02372.15 EFO63176.1 - 9.6 6.2 10.4 2.2 8.3 5.2 2.7 2 0 0 2 2 2 0 Interleukin 15 HORMA PF02301.18 EFO63177.1 - 5.5e-30 104.5 0.1 3.4e-28 98.7 0.1 2.1 1 1 0 1 1 1 1 HORMA domain ThiF PF00899.21 EFO63178.1 - 8e-23 81.0 0.0 1.1e-22 80.6 0.0 1.2 1 0 0 1 1 1 1 ThiF family Tubulin_2 PF13809.6 EFO63178.1 - 0.0006 19.1 0.0 0.00085 18.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin like Ras PF00071.22 EFO63180.1 - 7e-10 38.7 0.0 8.2e-10 38.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFO63180.1 - 2.9e-05 24.3 0.0 4e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFO63180.1 - 6.4e-05 23.0 0.0 8.8e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFO63180.1 - 0.012 15.2 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_31 PF13614.6 EFO63180.1 - 0.022 14.7 0.0 0.03 14.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFO63180.1 - 0.06 13.3 0.0 8.3 6.3 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase Dynamin_N PF00350.23 EFO63180.1 - 0.071 13.2 0.0 0.52 10.3 0.0 2.2 2 1 0 2 2 2 0 Dynamin family ANAPC4_WD40 PF12894.7 EFO63181.1 - 8.5e-06 26.0 0.0 3.6 8.0 0.0 4.1 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFO63181.1 - 4.7e-05 24.1 2.6 2.8 8.9 0.0 5.7 6 0 0 6 6 6 1 WD domain, G-beta repeat BBS2_N PF14781.6 EFO63181.1 - 0.048 13.6 0.1 7.5 6.5 0.0 3.0 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, N-terminal DUF1269 PF06897.12 EFO63181.1 - 0.085 13.1 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1269) zf-CCCH PF00642.24 EFO63182.1 - 8.1e-07 28.8 3.6 1.2e-06 28.3 3.6 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFO63182.1 - 9.7e-07 28.6 4.0 1.4e-06 28.1 4.0 1.3 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 EFO63182.1 - 0.00061 19.5 2.6 0.00096 18.9 2.6 1.2 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EFO63182.1 - 0.33 11.5 2.3 0.64 10.6 2.3 1.5 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger DUF2298 PF10060.9 EFO63183.1 - 0.03 13.1 3.7 0.037 12.7 3.7 1.1 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) Pkinase PF00069.25 EFO63184.1 - 3.3e-56 190.6 0.0 6e-56 189.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63184.1 - 2.4e-27 95.8 0.0 6.1e-26 91.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO63184.1 - 0.0044 16.4 0.2 0.15 11.3 0.1 2.1 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EFO63184.1 - 0.019 13.9 0.1 0.031 13.2 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EFO63184.1 - 0.13 11.6 0.2 0.23 10.8 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family STIMATE PF12400.8 EFO63185.1 - 0.12 13.0 3.9 0.074 13.6 1.5 2.0 2 1 0 2 2 2 0 STIMATE family PDEase_I PF00233.19 EFO63186.1 - 3.8e-06 26.8 0.4 9e-06 25.6 0.4 1.7 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase SAM_Exu PF18609.1 EFO63189.1 - 0.095 12.8 1.1 1.6 8.9 0.2 3.8 2 0 0 2 2 2 0 Exuperantia SAM-like domain PI_PP_I PF18363.1 EFO63189.1 - 1.6 9.0 16.4 0.024 14.8 1.6 4.7 3 1 2 5 5 5 0 Phosphoinositide phosphatase insertion domain V-ATPase_H_C PF11698.8 EFO63190.1 - 0.023 14.8 0.1 0.048 13.8 0.1 1.6 1 0 0 1 1 1 0 V-ATPase subunit H DUF778 PF05608.12 EFO63191.1 - 1.3e-21 77.8 1.9 9.1e-13 49.0 0.2 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF778) Peptidase_C97 PF05903.14 EFO63191.1 - 5.4e-06 26.3 0.0 6.1e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF4796 PF16044.5 EFO63191.1 - 0.0001 21.9 0.5 0.00018 21.2 0.5 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4796) LRAT PF04970.13 EFO63191.1 - 0.074 13.4 0.0 0.097 13.0 0.0 1.4 1 0 0 1 1 1 0 Lecithin retinol acyltransferase Gar1 PF04410.14 EFO63192.1 - 8.4e-06 25.6 0.0 2e-05 24.4 0.0 1.6 1 1 0 1 1 1 1 Gar1/Naf1 RNA binding region RecA PF00154.21 EFO63192.1 - 0.12 11.9 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein Helicase_C PF00271.31 EFO63193.1 - 8.7e-11 42.1 0.0 4.7e-10 39.8 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFO63193.1 - 6.1e-10 39.1 0.1 2.4e-07 30.7 0.0 3.0 2 1 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EFO63193.1 - 0.024 14.6 0.0 0.079 13.0 0.0 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit VSP PF03302.13 EFO63194.1 - 1.1e-51 176.0 174.5 3.7e-29 101.8 35.7 7.0 1 1 6 7 7 7 5 Giardia variant-specific surface protein GF_recep_IV PF14843.6 EFO63194.1 - 0.00099 18.9 31.8 0.00099 18.9 31.8 5.8 1 1 4 5 5 5 1 Growth factor receptor domain IV NOG1_N PF17835.1 EFO63195.1 - 1.4e-52 177.9 0.5 2.6e-52 177.0 0.5 1.5 1 0 0 1 1 1 1 NOG1 N-terminal helical domain MMR_HSR1 PF01926.23 EFO63195.1 - 6.5e-18 64.9 0.0 1.3e-17 63.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase NOGCT PF08155.11 EFO63195.1 - 1.4e-17 63.4 1.5 3e-17 62.4 1.5 1.6 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 EFO63195.1 - 1.7e-16 59.7 0.2 3.7e-16 58.7 0.2 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) FeoB_N PF02421.18 EFO63195.1 - 1e-10 41.3 0.0 1.8e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFO63195.1 - 2.2e-05 24.6 0.0 0.027 14.5 0.0 2.7 1 1 1 2 2 2 2 Dynamin family AIG1 PF04548.16 EFO63195.1 - 7.8e-05 22.1 0.0 0.00016 21.1 0.0 1.5 1 0 0 1 1 1 1 AIG1 family AAA_16 PF13191.6 EFO63195.1 - 0.00026 21.4 0.3 0.001 19.5 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFO63195.1 - 0.022 14.6 0.1 0.63 9.9 0.0 2.7 2 1 0 2 2 2 0 RsgA GTPase SRPRB PF09439.10 EFO63195.1 - 0.024 14.1 0.0 0.058 12.8 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Sec34 PF04136.15 EFO63195.1 - 0.057 13.3 0.1 0.29 11.0 0.0 2.2 1 1 1 2 2 2 0 Sec34-like family AAA_29 PF13555.6 EFO63195.1 - 0.16 11.7 0.0 0.41 10.4 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.6 EFO63195.1 - 0.42 10.8 1.8 3.3 7.9 0.0 2.9 3 1 0 3 3 3 0 AAA domain Ank_2 PF12796.7 EFO63197.1 - 1.1e-46 157.3 7.9 2e-12 47.5 0.6 6.4 3 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63197.1 - 1.9e-26 91.8 14.5 0.0002 21.6 0.0 8.6 4 2 4 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO63197.1 - 3.5e-23 81.0 5.1 0.0037 17.7 0.0 9.1 9 1 0 9 9 9 5 Ankyrin repeat Ank_3 PF13606.6 EFO63197.1 - 2.4e-22 76.6 9.5 0.015 15.7 0.0 10.2 11 0 0 11 11 11 5 Ankyrin repeat Ank_4 PF13637.6 EFO63197.1 - 1.2e-18 67.2 6.1 0.00052 20.5 0.0 7.9 5 1 3 8 8 8 4 Ankyrin repeats (many copies) UPF0242 PF06785.11 EFO63197.1 - 0.0025 18.0 2.7 0.0025 18.0 2.7 4.1 2 1 1 3 3 3 1 Uncharacterised protein family (UPF0242) N-terminus DUF190 PF02641.15 EFO63197.1 - 0.012 16.0 0.1 0.033 14.5 0.1 1.8 1 0 0 1 1 1 0 Uncharacterized ACR, COG1993 SNF2_N PF00176.23 EFO63198.1 - 8.2e-58 195.8 0.3 8.2e-58 195.8 0.3 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFO63198.1 - 3.8e-17 62.6 0.0 1.2e-16 61.0 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DBINO PF13892.6 EFO63198.1 - 8.5e-07 29.4 5.4 2.3e-06 28.0 5.4 1.6 1 0 0 1 1 1 1 DNA-binding domain HDA2-3 PF11496.8 EFO63198.1 - 3.9e-05 23.0 0.2 0.00012 21.3 0.2 1.8 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 EFO63198.1 - 0.00055 20.0 0.0 0.0017 18.4 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Dcc1 PF09724.9 EFO63199.1 - 2.5e-06 27.0 0.0 0.038 13.3 0.0 2.2 2 0 0 2 2 2 2 Sister chromatid cohesion protein Dcc1 RGS PF00615.19 EFO63199.1 - 0.18 12.1 0.0 0.36 11.1 0.0 1.4 1 0 0 1 1 1 0 Regulator of G protein signaling domain EGF_2 PF07974.13 EFO63200.1 - 2.2e-17 63.1 159.8 2.8e-05 24.4 8.1 12.7 14 0 0 14 14 14 10 EGF-like domain EGF_CA PF07645.15 EFO63200.1 - 0.00039 20.6 7.8 0.00039 20.6 7.8 10.7 9 4 1 10 10 10 1 Calcium-binding EGF domain EGF PF00008.27 EFO63200.1 - 0.00048 20.4 15.3 0.0013 19.0 5.9 12.9 10 4 1 11 11 11 7 EGF-like domain EGF_MSP1_1 PF12946.7 EFO63200.1 - 0.00051 20.0 3.5 0.00051 20.0 3.5 7.6 10 0 0 10 10 10 1 MSP1 EGF domain 1 hEGF PF12661.7 EFO63200.1 - 0.0051 17.4 18.8 0.0071 16.9 6.6 14.5 14 1 1 15 15 15 4 Human growth factor-like EGF EGF_Tenascin PF18720.1 EFO63200.1 - 0.017 15.2 7.8 0.017 15.2 7.8 13.7 10 2 5 15 15 15 0 Tenascin EGF domain EGF_3 PF12947.7 EFO63200.1 - 0.029 14.6 3.1 0.029 14.6 3.1 10.6 10 1 1 11 11 11 0 EGF domain Asparaginase PF00710.20 EFO63201.1 - 2.9e-59 199.9 0.0 4.2e-59 199.3 0.0 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EFO63201.1 - 7.5e-19 68.0 0.1 1.1e-18 67.5 0.1 1.3 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ribosomal_L31e PF01198.19 EFO63202.1 - 3.4e-19 68.9 0.3 6.1e-19 68.0 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L31e Arm PF00514.23 EFO63203.1 - 3e-15 55.6 5.3 0.012 15.6 0.0 8.8 9 0 0 9 9 9 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EFO63203.1 - 7.7e-06 26.2 0.4 0.18 12.2 0.0 4.2 3 0 0 3 3 3 2 HEAT repeats V-ATPase_H_N PF03224.14 EFO63203.1 - 0.00011 21.7 0.0 0.01 15.1 0.0 3.2 3 1 0 3 3 3 1 V-ATPase subunit H HEAT PF02985.22 EFO63203.1 - 1.9 8.9 9.6 1.1e+02 3.4 0.1 6.1 6 0 0 6 6 6 0 HEAT repeat Ribosomal_L23eN PF03939.13 EFO63204.1 - 3.9e-15 55.8 5.3 6e-15 55.2 5.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 EFO63204.1 - 2.3e-12 47.1 2.0 2.3e-12 47.1 2.0 2.5 2 1 0 2 2 2 1 Ribosomal protein L23 Acylphosphatase PF00708.18 EFO63205.1 - 3.8e-26 91.3 0.0 4.2e-26 91.2 0.0 1.0 1 0 0 1 1 1 1 Acylphosphatase DUF2871 PF11070.8 EFO63205.1 - 0.076 13.3 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2871) YIF1 PF03878.15 EFO63206.1 - 7.2e-13 48.6 11.4 1.9e-11 44.0 11.4 2.0 1 1 0 1 1 1 1 YIF1 Kinesin PF00225.23 EFO63207.1 - 7.7e-111 370.2 1.0 7.7e-111 370.2 1.0 1.6 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFO63207.1 - 4.9e-26 91.5 1.3 1.7e-25 89.7 0.1 2.4 2 0 0 2 2 2 1 Microtubule binding AAA_25 PF13481.6 EFO63207.1 - 0.092 12.3 0.1 15 5.1 0.1 2.3 2 0 0 2 2 2 0 AAA domain DUF4559 PF15112.6 EFO63207.1 - 0.22 11.2 12.7 0.59 9.7 12.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) DUF1192 PF06698.11 EFO63207.1 - 0.45 10.6 6.1 11 6.2 1.7 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) ParcG PF10274.9 EFO63208.1 - 1.1e-77 260.3 0.1 1.4e-77 260.0 0.1 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein DCB PF16213.5 EFO63208.1 - 0.1 12.2 0.0 0.14 11.8 0.0 1.1 1 0 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 Ribosomal_S11 PF00411.19 EFO63211.1 - 3e-33 114.5 1.7 3.7e-33 114.2 1.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 MAT1 PF06391.13 EFO63213.1 - 0.033 14.0 0.3 0.035 13.9 0.3 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 NPA PF16469.5 EFO63213.1 - 0.056 14.0 0.5 0.072 13.7 0.5 1.2 1 0 0 1 1 1 0 Nematode polyprotein allergen ABA-1 Thiol_cytolysin PF01289.19 EFO63213.1 - 0.091 11.7 0.1 0.098 11.5 0.1 1.2 1 0 0 1 1 1 0 Thiol-activated cytolysin XPC-binding PF09280.11 EFO63213.1 - 0.12 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 XPC-binding domain VSP PF03302.13 EFO63214.1 - 4.4e-05 22.5 55.3 0.028 13.3 24.3 3.3 1 1 2 3 3 3 3 Giardia variant-specific surface protein DUF1450 PF07293.11 EFO63214.1 - 0.075 12.9 0.2 0.075 12.9 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1450) VSP PF03302.13 EFO63215.1 - 4.6e-79 266.1 157.9 9.2e-29 100.5 24.4 6.5 1 1 4 5 5 5 5 Giardia variant-specific surface protein Ephrin_rec_like PF07699.13 EFO63215.1 - 0.0031 17.2 5.0 0.0031 17.2 5.0 12.9 8 3 4 12 12 12 3 Putative ephrin-receptor like Furin-like_2 PF15913.5 EFO63215.1 - 0.012 15.8 3.1 0.012 15.8 3.1 9.7 1 1 8 9 9 9 0 Furin-like repeat, cysteine-rich PsiE PF06146.12 EFO63217.1 - 6.3e-14 52.1 5.2 6.3e-14 52.1 5.2 2.2 2 0 0 2 2 2 1 Phosphate-starvation-inducible E Ferlin_C PF16165.5 EFO63217.1 - 0.18 11.8 0.2 0.46 10.4 0.0 1.8 2 0 0 2 2 2 0 Ferlin C-terminus TraG_N PF07916.11 EFO63217.1 - 0.44 9.3 4.1 2 7.2 4.1 2.1 1 1 0 1 1 1 0 TraG-like protein, N-terminal region PsbN PF02468.15 EFO63217.1 - 4.8 7.1 7.6 0.8 9.6 0.4 2.7 3 0 0 3 3 3 0 Photosystem II reaction centre N protein (psbN) tRNA-synt_1e PF01406.19 EFO63218.1 - 1.3e-90 303.9 0.0 2.5e-90 302.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EFO63218.1 - 1.5e-08 33.8 1.2 0.0013 17.5 0.1 2.9 3 0 0 3 3 3 2 tRNA synthetases class I (M) SPDY PF03771.16 EFO63218.1 - 0.34 10.9 1.7 0.59 10.1 0.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF317) DUF2207 PF09972.9 EFO63219.1 - 0.0031 16.3 0.1 0.0035 16.2 0.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Phage_holin_3_6 PF07332.11 EFO63219.1 - 0.033 14.2 3.3 0.052 13.6 3.3 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III GPI2 PF06432.11 EFO63219.1 - 0.17 11.3 4.8 0.21 11.0 4.8 1.0 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase Orf78 PF06024.12 EFO63219.1 - 0.22 11.9 2.0 0.59 10.5 2.0 1.8 1 1 0 1 1 1 0 Orf78 (ac78) ERGIC_N PF13850.6 EFO63219.1 - 0.38 11.1 2.4 0.36 11.2 1.1 1.6 1 1 0 1 1 1 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Peptidase_M48_N PF16491.5 EFO63219.1 - 0.88 9.4 6.7 1.1 9.1 6.7 1.2 1 0 0 1 1 1 0 CAAX prenyl protease N-terminal, five membrane helices DUF2116 PF09889.9 EFO63219.1 - 3.7 7.6 5.9 0.59 10.2 0.8 2.1 1 1 1 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Laminin_EGF PF00053.24 EFO63220.1 - 0.0008 19.5 4.0 0.0008 19.5 4.0 6.7 4 1 0 4 4 4 1 Laminin EGF domain EGF_2 PF07974.13 EFO63220.1 - 0.0011 19.3 65.3 0.053 13.9 4.7 7.8 7 1 0 7 7 7 4 EGF-like domain hEGF PF12661.7 EFO63220.1 - 0.018 15.7 3.1 0.018 15.7 3.1 7.8 8 0 0 8 8 8 0 Human growth factor-like EGF EGF PF00008.27 EFO63220.1 - 0.043 14.1 2.3 0.043 14.1 2.3 7.5 7 2 0 7 7 7 0 EGF-like domain MMR_HSR1_Xtn PF16897.5 EFO63221.1 - 2.6e-34 117.4 1.9 4.9e-34 116.5 1.9 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EFO63221.1 - 6.2e-18 64.9 0.0 1.4e-17 63.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EFO63221.1 - 1.5e-16 60.2 0.0 2.9e-16 59.3 0.0 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EFO63221.1 - 5e-09 35.9 0.3 3e-08 33.3 0.0 2.3 3 0 0 3 3 3 1 Ferrous iron transport protein B Ras PF00071.22 EFO63221.1 - 0.0035 17.0 0.1 0.35 10.5 0.0 2.4 2 0 0 2 2 2 1 Ras family Dynamin_N PF00350.23 EFO63221.1 - 0.011 15.8 0.1 1.1 9.2 0.0 2.4 1 1 1 2 2 2 0 Dynamin family Roc PF08477.13 EFO63221.1 - 0.03 14.5 0.0 0.26 11.5 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 EFO63221.1 - 0.065 12.2 0.4 1.4 7.9 0.0 2.5 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB EB1 PF03271.17 EFO63222.1 - 8.7e-09 35.5 1.3 2.3e-08 34.1 1.3 1.8 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 EFO63222.1 - 1.2e-07 31.9 1.2 2.1e-07 31.1 0.3 1.7 2 0 0 2 2 2 1 Calponin homology (CH) domain CH_2 PF06294.11 EFO63222.1 - 0.0053 16.8 0.1 0.012 15.7 0.1 1.7 1 0 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 EFO63222.1 - 0.12 12.2 0.1 0.57 10.1 0.0 2.1 2 0 0 2 2 2 0 CAMSAP CH domain PUCC PF03209.15 EFO63224.1 - 0.017 14.1 0.1 0.032 13.3 0.1 1.3 1 0 0 1 1 1 0 PUCC protein DUF4393 PF14337.6 EFO63224.1 - 0.14 12.0 0.4 0.27 11.0 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4393) CM2 PF03021.14 EFO63224.1 - 0.37 10.6 4.2 3 7.7 0.3 3.1 3 0 0 3 3 3 0 Influenza C virus M2 protein Ribosomal_L32e PF01655.18 EFO63225.1 - 3.7e-43 146.3 0.7 4.6e-43 146.1 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 Pkinase PF00069.25 EFO63228.1 - 1.1e-67 228.1 0.2 1.4e-67 227.9 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63228.1 - 2.6e-46 158.0 0.0 3.7e-46 157.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO63228.1 - 1.6e-07 30.9 0.0 6.3e-07 29.0 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFO63228.1 - 9.9e-07 27.9 0.0 1.5e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFO63228.1 - 0.32 10.9 2.3 0.43 10.5 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF3552 PF12072.8 EFO63228.1 - 0.32 10.4 4.3 0.072 12.5 0.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) EXS PF03124.14 EFO63229.1 - 1.4e-36 126.5 17.8 2e-36 126.0 17.8 1.2 1 0 0 1 1 1 1 EXS family SPX PF03105.19 EFO63229.1 - 2.5e-22 80.3 7.3 5e-10 39.8 0.0 2.3 1 1 1 2 2 2 2 SPX domain VSP PF03302.13 EFO63230.1 - 3.3e-74 250.1 338.1 1.2e-41 143.0 77.1 8.7 1 1 8 9 9 9 5 Giardia variant-specific surface protein BRCT PF00533.26 EFO63231.1 - 1.1e-08 35.3 0.0 4.2e-08 33.5 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 EFO63231.1 - 5.2e-07 30.2 0.0 1.3e-06 28.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFO63231.1 - 0.0087 16.3 0.0 0.021 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFO63231.1 - 0.012 16.0 0.0 0.2 12.0 0.0 2.5 1 1 1 2 2 2 0 AAA ATPase domain DNA_pol3_delta2 PF13177.6 EFO63231.1 - 0.019 14.8 0.0 0.068 12.9 0.0 1.9 2 0 0 2 2 2 0 DNA polymerase III, delta subunit DNA_pol3_delta PF06144.13 EFO63231.1 - 0.021 14.6 0.0 0.062 13.1 0.0 1.8 1 0 0 1 1 1 0 DNA polymerase III, delta subunit Mcl1_mid PF12341.8 EFO63231.1 - 0.1 11.9 0.0 0.5 9.7 0.0 2.0 2 0 0 2 2 2 0 Minichromosome loss protein, Mcl1, middle region SURF6 PF04935.12 EFO63232.1 - 3.7e-06 26.9 10.7 5.2e-06 26.4 10.7 1.2 1 0 0 1 1 1 1 Surfeit locus protein 6 DUF3881 PF12997.7 EFO63232.1 - 0.017 14.4 0.4 0.022 14.0 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3881) HTH_16 PF12645.7 EFO63232.1 - 0.049 13.7 0.1 0.089 12.9 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HGTP_anticodon2 PF12745.7 EFO63232.1 - 0.35 10.3 3.5 0.52 9.8 3.5 1.3 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Ribosomal_L34e PF01199.18 EFO63233.1 - 7.4e-25 87.1 2.2 7.4e-25 87.1 2.2 1.5 2 0 0 2 2 2 1 Ribosomal protein L34e Thioredoxin PF00085.20 EFO63234.1 - 4.1e-24 84.5 0.1 2.2e-23 82.2 0.0 2.0 2 1 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 EFO63234.1 - 1.8e-05 25.1 0.0 5.8e-05 23.5 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_6 PF13848.6 EFO63234.1 - 0.00033 20.6 0.9 0.017 15.1 0.4 3.0 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EFO63234.1 - 0.075 13.2 0.0 0.22 11.7 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin-like Thioredoxin_5 PF13743.6 EFO63234.1 - 0.094 12.4 0.3 14 5.4 0.0 3.0 2 1 1 3 3 3 0 Thioredoxin RNase_PH PF01138.21 EFO63235.1 - 1.2 9.7 3.7 0.36 11.3 0.2 1.9 2 0 0 2 2 2 0 3' exoribonuclease family, domain 1 BofA PF07441.11 EFO63235.1 - 2 8.7 12.3 0.18 12.0 0.6 2.9 3 1 0 3 3 3 0 SigmaK-factor processing regulatory protein BofA DUF5423 PF17461.2 EFO63235.1 - 2.7 6.8 5.3 1.9 7.2 1.5 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5423) NDK PF00334.19 EFO63236.1 - 9.8e-57 190.7 0.0 1.1e-56 190.6 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase PSI_PsaJ PF01701.18 EFO63236.1 - 0.039 14.5 0.0 0.073 13.6 0.0 1.4 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IX / PsaJ Aa_trans PF01490.18 EFO63237.1 - 1.2e-08 34.1 42.0 5.2e-08 32.0 27.0 2.4 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein Pkinase PF00069.25 EFO63240.1 - 3.6e-54 183.9 0.0 1.6e-53 181.8 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63240.1 - 6.3e-28 97.8 0.0 1e-27 97.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO63240.1 - 0.0002 20.8 0.0 0.00037 19.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFO63240.1 - 0.00057 18.9 0.0 0.001 18.1 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFO63240.1 - 0.014 14.2 0.0 0.021 13.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase ERCC3_RAD25_C PF16203.5 EFO63241.1 - 3.1e-59 200.2 0.9 1e-56 191.9 0.3 2.8 2 1 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EFO63241.1 - 5.3e-18 65.4 0.0 1.3e-17 64.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFO63241.1 - 7.1e-17 61.9 0.1 2.1e-16 60.4 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFO63241.1 - 7.7e-12 45.5 0.0 5.6e-11 42.8 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EFO63241.1 - 6.9e-09 34.9 0.0 1.3e-08 34.0 0.0 1.4 1 1 0 1 1 1 1 SNF2 family N-terminal domain SWI2_SNF2 PF18766.1 EFO63241.1 - 2.5e-07 30.6 0.1 8.4e-07 28.9 0.0 1.9 2 0 0 2 2 2 1 SWI2/SNF2 ATPase Ribosomal_L7Ae PF01248.26 EFO63242.1 - 3.3e-23 81.2 0.3 4e-23 81.0 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Macro PF01661.21 EFO63244.1 - 6e-08 32.7 0.0 9.5e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Macro domain BACON PF13004.7 EFO63244.1 - 0.016 15.2 0.4 0.024 14.6 0.4 1.4 1 0 0 1 1 1 0 Putative binding domain, N-terminal Ank_2 PF12796.7 EFO63245.1 - 4.3e-42 142.6 14.7 8.2e-11 42.3 0.4 6.0 3 2 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63245.1 - 6.3e-23 80.9 10.3 4.1e-06 27.2 0.0 8.1 8 2 2 10 10 10 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63245.1 - 6.3e-23 78.4 10.8 0.0081 16.6 0.0 11.1 11 0 0 11 11 11 5 Ankyrin repeat Ank PF00023.30 EFO63245.1 - 3.6e-22 77.8 16.8 0.0012 19.2 0.0 9.8 11 0 0 11 11 11 7 Ankyrin repeat Ank_5 PF13857.6 EFO63245.1 - 3.9e-19 68.5 12.1 6.2e-09 36.0 0.1 8.9 6 3 4 10 10 10 5 Ankyrin repeats (many copies) OSCP PF00213.18 EFO63245.1 - 0.12 12.4 3.9 1.5 8.9 0.1 2.6 2 0 0 2 2 2 0 ATP synthase delta (OSCP) subunit Ank_2 PF12796.7 EFO63246.1 - 1.3e-33 115.5 12.0 3e-11 43.7 0.1 5.5 2 2 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63246.1 - 1.8e-23 82.3 6.0 0.00077 19.7 0.0 7.0 4 1 3 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO63246.1 - 6.2e-20 70.7 3.9 0.0028 18.0 0.0 8.1 8 0 0 8 8 8 6 Ankyrin repeat Ank_3 PF13606.6 EFO63246.1 - 1.5e-16 58.8 3.5 0.27 11.9 0.0 8.0 7 0 0 7 7 7 4 Ankyrin repeat Ank_4 PF13637.6 EFO63246.1 - 1.7e-16 60.4 6.3 0.00012 22.5 0.0 7.0 7 2 0 7 7 7 3 Ankyrin repeats (many copies) TPR_MLP1_2 PF07926.12 EFO63246.1 - 0.0038 17.3 12.6 0.0038 17.3 12.6 8.4 5 2 2 7 7 7 1 TPR/MLP1/MLP2-like protein Peptidase_C74 PF12387.8 EFO63246.1 - 0.084 12.3 0.0 0.39 10.2 0.0 2.0 2 0 0 2 2 2 0 Pestivirus NS2 peptidase DUF4060 PF13269.6 EFO63247.1 - 0.21 11.7 0.3 0.97 9.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4060) Pkinase PF00069.25 EFO63248.1 - 2.2e-55 187.9 0.0 3.4e-55 187.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63248.1 - 2e-42 145.3 0.0 5.1e-42 143.9 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFO63248.1 - 0.00094 18.1 0.0 0.0015 17.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase HIT PF01230.23 EFO63249.1 - 4.8e-26 91.4 0.0 6e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EFO63249.1 - 1.3e-14 54.7 0.0 1.5e-14 54.4 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding RNA_pol_Rpc82 PF05645.13 EFO63250.1 - 5e-25 88.7 0.0 2.4e-18 66.8 0.0 2.3 1 1 1 2 2 2 2 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 EFO63250.1 - 7.7e-18 64.4 0.1 1.9e-17 63.1 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 helix-turn-helix domain HTH_IclR PF09339.10 EFO63250.1 - 0.033 14.0 2.0 0.051 13.4 0.2 2.3 2 1 0 2 2 2 0 IclR helix-turn-helix domain RhoGAP PF00620.27 EFO63251.1 - 3.1e-17 62.8 0.0 4.1e-17 62.4 0.0 1.1 1 0 0 1 1 1 1 RhoGAP domain MICSWaP PF17018.5 EFO63251.1 - 0.019 14.5 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Spore wall protein FAP206 PF12018.8 EFO63252.1 - 0.025 14.1 0.2 0.032 13.7 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function GLE1 PF07817.13 EFO63252.1 - 0.035 13.3 0.1 0.04 13.1 0.1 1.0 1 0 0 1 1 1 0 GLE1-like protein MscS_porin PF12795.7 EFO63252.1 - 0.05 13.1 0.3 0.055 13.0 0.3 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain DUF5082 PF16888.5 EFO63253.1 - 0.066 13.5 0.3 0.095 13.0 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) Asr PF06392.11 EFO63255.1 - 0.12 12.8 0.9 0.3 11.5 0.9 1.7 1 0 0 1 1 1 0 Acid shock protein repeat Hom_end_hint PF05203.16 EFO63256.1 - 7.4e-09 35.9 0.0 3.7e-08 33.6 0.0 1.9 1 1 0 1 1 1 1 Hom_end-associated Hint Hom_end PF05204.14 EFO63256.1 - 0.17 12.1 0.0 0.41 10.8 0.0 1.6 1 0 0 1 1 1 0 Homing endonuclease RNase_PH PF01138.21 EFO63258.1 - 2.7e-05 24.7 1.7 0.00036 21.0 0.2 2.9 2 2 0 2 2 2 1 3' exoribonuclease family, domain 1 Ank_2 PF12796.7 EFO63260.1 - 9.3e-35 119.1 15.8 1.3e-08 35.3 0.1 6.6 1 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63260.1 - 3.7e-18 65.6 9.5 0.00061 20.3 0.1 8.8 8 2 1 9 9 8 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63260.1 - 3.9e-15 54.4 9.9 0.14 12.8 0.0 10.4 10 0 0 10 10 10 3 Ankyrin repeat Ank PF00023.30 EFO63260.1 - 7.9e-14 51.4 20.4 0.0028 18.0 0.0 10.2 10 1 1 11 11 11 3 Ankyrin repeat Ank_5 PF13857.6 EFO63260.1 - 2.1e-13 50.2 12.1 0.044 14.1 0.1 8.5 4 2 5 9 9 9 5 Ankyrin repeats (many copies) PK_C PF02887.16 EFO63260.1 - 0.044 14.0 0.2 3.8 7.8 0.0 3.0 3 0 0 3 3 3 0 Pyruvate kinase, alpha/beta domain Nse4_C PF08743.10 EFO63261.1 - 0.00013 22.2 0.1 0.00054 20.2 0.1 1.9 1 1 0 1 1 1 1 Nse4 C-terminal CS PF04969.16 EFO63262.1 - 1.2e-13 51.8 0.0 1.8e-13 51.3 0.0 1.2 1 0 0 1 1 1 1 CS domain Ribosomal_L16 PF00252.18 EFO63263.1 - 1.2e-40 138.6 0.0 1.5e-40 138.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e U83 PF17465.2 EFO63263.1 - 0.025 14.7 0.0 0.04 14.1 0.0 1.2 1 0 0 1 1 1 0 Chemokine-like protein, HHV-6 U83 gene product Cytochrome_P460 PF16694.5 EFO63263.1 - 0.14 12.5 0.0 0.25 11.7 0.0 1.4 1 0 0 1 1 1 0 Cytochrome P460 RRM_1 PF00076.22 EFO63264.1 - 0.00018 21.2 0.0 0.00021 21.0 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LapA_dom PF06305.11 EFO63265.1 - 0.35 10.7 0.0 0.35 10.7 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Aha1_N PF09229.11 EFO63266.1 - 1.9e-14 54.0 0.5 2.3e-14 53.8 0.5 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal DUF4100 PF13352.6 EFO63266.1 - 0.08 12.7 0.1 0.1 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4100) HU-CCDC81_euk_1 PF14908.6 EFO63267.1 - 0.00031 20.8 0.2 0.015 15.4 0.1 2.4 2 0 0 2 2 2 1 CCDC81 eukaryotic HU domain 1 HU-CCDC81_euk_2 PF18289.1 EFO63267.1 - 0.0018 18.4 0.0 0.0034 17.5 0.0 1.4 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 2 IP_trans PF02121.18 EFO63268.1 - 0.036 13.6 0.6 0.83 9.2 0.2 2.1 1 1 1 2 2 2 0 Phosphatidylinositol transfer protein EMP24_GP25L PF01105.24 EFO63269.1 - 7.3e-22 78.2 0.0 8.3e-22 78.0 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD TMEM191C PF15194.6 EFO63269.1 - 0.024 14.8 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 TMEM191C family Not1 PF04054.15 EFO63271.1 - 8.2e-11 41.4 6.4 5.6e-10 38.7 0.3 3.4 3 0 0 3 3 3 2 CCR4-Not complex component, Not1 CNOT1_HEAT PF16418.5 EFO63271.1 - 2e-09 37.7 0.0 8.3e-09 35.7 0.0 2.1 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat zf-rbx1 PF12678.7 EFO63273.1 - 2.4e-07 30.9 0.2 2.4e-07 30.9 0.2 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EFO63273.1 - 5.9e-07 29.7 0.2 5.9e-07 29.7 0.2 2.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFO63273.1 - 5.2e-06 26.2 0.2 5.2e-06 26.2 0.2 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFO63273.1 - 1.9e-05 24.6 2.2 7.9e-05 22.6 0.2 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFO63273.1 - 2.4e-05 24.1 0.4 0.00043 20.1 0.0 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFO63273.1 - 2.4e-05 24.2 0.0 2.4e-05 24.2 0.0 3.0 3 0 0 3 3 3 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EFO63273.1 - 0.00042 19.9 0.7 0.00042 19.9 0.7 1.9 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 EFO63273.1 - 0.005 16.6 0.1 0.005 16.6 0.1 3.0 3 0 0 3 3 3 1 RING-like zinc finger zf-ANAPC11 PF12861.7 EFO63273.1 - 0.0067 16.4 2.1 0.0079 16.2 0.0 2.2 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EFO63273.1 - 0.032 14.1 2.1 0.089 12.7 0.0 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO63273.1 - 0.11 12.3 3.3 0.13 12.2 0.0 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 FANCL_C PF11793.8 EFO63273.1 - 0.34 11.1 2.7 0.77 10.0 0.3 2.3 2 0 0 2 2 2 0 FANCL C-terminal domain NFACT-R_1 PF05670.13 EFO63274.1 - 2e-25 89.6 0.0 1.9e-24 86.4 0.0 2.7 2 0 0 2 2 2 1 NFACT protein RNA binding domain FbpA PF05833.11 EFO63274.1 - 9.2e-14 51.0 0.2 9.2e-14 51.0 0.2 3.1 2 1 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-C PF11923.8 EFO63274.1 - 0.0015 18.4 3.4 0.002 18.0 0.0 2.8 3 0 0 3 3 3 1 NFACT protein C-terminal domain zf-CCHC_4 PF14392.6 EFO63274.1 - 1.2 8.9 6.7 0.88 9.4 4.1 2.2 3 0 0 3 3 3 0 Zinc knuckle DUF1974 PF09317.11 EFO63274.1 - 7.5 6.0 8.2 12 5.3 4.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1974) Pkinase PF00069.25 EFO63275.1 - 8.1e-31 107.3 0.0 2.1e-30 106.0 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63275.1 - 5.7e-25 88.1 0.0 6.9e-25 87.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFO63275.1 - 0.038 13.9 0.0 0.085 12.8 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ank_2 PF12796.7 EFO63276.1 - 2.1e-42 143.6 0.9 1.5e-13 51.2 0.1 3.0 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63276.1 - 1.4e-18 66.7 1.0 4.3e-06 26.9 0.1 4.3 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO63276.1 - 1.9e-14 53.4 0.0 0.0016 18.8 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EFO63276.1 - 3.9e-14 52.8 0.0 0.00023 21.6 0.0 3.6 3 1 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63276.1 - 4.1e-14 51.3 0.0 0.00039 20.7 0.0 5.1 4 1 1 5 5 5 3 Ankyrin repeat Pkinase PF00069.25 EFO63278.1 - 4.9e-68 229.3 0.0 6.4e-68 229.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63278.1 - 2.8e-27 95.6 0.0 7.1e-27 94.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO63279.1 - 1.3e-21 77.0 0.7 2.8e-12 47.1 0.1 4.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63279.1 - 1.5e-12 47.5 6.5 0.039 14.3 0.0 6.1 3 1 3 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63279.1 - 4.7e-12 45.0 0.6 1.5 9.6 0.0 7.1 7 0 0 7 7 7 3 Ankyrin repeat Ank_4 PF13637.6 EFO63279.1 - 1.9e-11 44.2 0.1 0.00044 20.8 0.0 4.4 4 1 0 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO63279.1 - 1.2e-08 35.0 2.2 7.9 7.1 0.0 6.4 6 1 1 7 7 7 4 Ankyrin repeat EF-hand_7 PF13499.6 EFO63282.1 - 8.1e-12 45.4 1.8 3.5e-07 30.6 0.3 4.4 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 EFO63282.1 - 5.4e-06 25.9 2.8 0.0046 16.8 0.1 4.3 4 0 0 4 4 4 1 EF-hand domain EF-hand_13 PF17958.1 EFO63282.1 - 8.3e-06 25.5 0.2 0.01 15.6 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 EFO63282.1 - 1.2e-05 24.5 0.7 0.28 10.8 0.1 3.7 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EFO63282.1 - 4.3e-05 23.3 0.3 0.36 10.7 0.1 4.2 4 1 0 4 4 4 2 EF-hand domain pair DUF3855 PF12967.7 EFO63284.1 - 0.019 15.0 0.0 0.032 14.2 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3855) Brix PF04427.18 EFO63286.1 - 2.4e-23 83.2 0.4 3.4e-23 82.7 0.4 1.2 1 0 0 1 1 1 1 Brix domain Cpn60_TCP1 PF00118.24 EFO63287.1 - 7.3e-149 496.5 9.7 8.3e-149 496.4 9.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Vps39_2 PF10367.9 EFO63288.1 - 1.5 9.3 4.8 20 5.7 0.6 3.4 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 Pro_isomerase PF00160.21 EFO63289.1 - 6.1e-46 156.6 0.3 6.8e-46 156.4 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ribosomal_L5 PF00281.19 EFO63290.1 - 0.094 13.1 0.0 0.25 11.7 0.0 1.7 1 0 0 1 1 1 0 Ribosomal protein L5 CAP_N PF01213.19 EFO63290.1 - 0.11 12.0 0.1 0.16 11.4 0.1 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal CEP63 PF17045.5 EFO63290.1 - 0.13 12.1 1.4 0.2 11.6 1.4 1.2 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa HECT PF00632.25 EFO63291.1 - 1.4e-23 83.9 0.0 5.2e-23 82.0 0.0 1.8 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Autoind_synth PF00765.17 EFO63292.1 - 0.0084 15.7 0.1 0.051 13.1 0.1 2.1 2 0 0 2 2 2 1 Autoinducer synthase MBOAT_2 PF13813.6 EFO63292.1 - 0.14 12.5 0.1 0.66 10.3 0.1 2.2 2 0 0 2 2 2 0 Membrane bound O-acyl transferase family zf-C2H2 PF00096.26 EFO63293.1 - 3e-08 33.7 27.6 0.0023 18.3 0.6 6.1 7 0 0 7 7 7 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFO63293.1 - 6e-08 32.9 30.3 0.037 14.9 0.7 6.4 6 1 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFO63293.1 - 5.8e-06 26.4 9.8 0.024 14.9 0.1 4.6 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 EFO63293.1 - 0.00096 19.5 14.4 0.23 11.9 0.1 5.4 5 0 0 5 5 5 2 Zinc-finger double domain zf-Di19 PF05605.12 EFO63293.1 - 0.004 17.4 25.4 0.011 16.0 3.4 4.8 4 1 1 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_3rep PF18868.1 EFO63293.1 - 0.014 16.1 7.0 2.8 8.6 0.2 3.7 2 2 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats Rad50_zn_hook PF04423.14 EFO63293.1 - 0.035 13.9 6.5 0.25 11.2 0.1 3.3 3 0 0 3 3 3 0 Rad50 zinc hook motif zf_C2H2_ZHX PF18387.1 EFO63293.1 - 0.31 10.7 8.2 14 5.4 1.8 3.6 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_12 PF18658.1 EFO63293.1 - 0.67 9.6 7.1 0.89 9.2 0.2 3.6 4 0 0 4 4 4 0 Zinc-finger C2H2-type zf-C2H2_2 PF12756.7 EFO63293.1 - 2.3 8.6 15.1 14 6.1 0.0 5.2 3 2 2 5 5 5 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_15 PF17032.5 EFO63293.1 - 5.6 7.8 8.1 11 6.8 1.8 3.8 3 1 0 3 3 3 0 zinc-ribbon family Ank_2 PF12796.7 EFO63294.1 - 0.011 16.3 0.1 0.017 15.7 0.1 1.4 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) MSC PF09402.10 EFO63296.1 - 5e-11 42.7 0.8 3.1e-09 36.8 0.0 2.4 2 0 0 2 2 2 1 Man1-Src1p-C-terminal domain DUF4229 PF14012.6 EFO63296.1 - 0.075 13.1 1.2 0.15 12.2 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4229) Apq12 PF12716.7 EFO63296.1 - 9.1 6.3 7.7 0.93 9.5 0.9 2.3 2 0 0 2 2 2 0 Nuclear pore assembly and biogenesis Ank_2 PF12796.7 EFO63297.1 - 1e-20 74.1 0.4 6.3e-11 42.7 0.1 2.8 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO63297.1 - 3.1e-14 51.7 0.4 0.00092 19.5 0.0 4.7 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EFO63297.1 - 6.2e-13 48.6 0.2 0.001 19.4 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EFO63297.1 - 1.6e-12 47.3 0.1 1.4e-05 25.2 0.0 3.6 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63297.1 - 2.7e-12 46.9 1.7 0.00011 22.6 0.0 4.3 4 1 1 5 5 4 2 Ankyrin repeats (many copies) zf-C2H2_jaz PF12171.8 EFO63298.1 - 0.013 15.8 5.8 0.016 15.5 1.2 2.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Actin_micro PF17003.5 EFO63298.1 - 0.051 12.8 5.6 0.065 12.4 5.6 1.2 1 0 0 1 1 1 0 Putative actin-like family Ank_2 PF12796.7 EFO63299.1 - 1.6e-29 102.3 7.2 2.9e-12 47.0 0.1 3.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63299.1 - 1e-15 57.6 2.8 0.00011 22.4 0.0 4.4 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63299.1 - 5.8e-15 55.5 0.1 0.00011 22.7 0.0 4.7 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63299.1 - 2e-14 52.2 0.1 0.063 13.8 0.0 5.1 5 0 0 5 5 4 4 Ankyrin repeat Ank PF00023.30 EFO63299.1 - 1.4e-11 44.3 2.5 0.017 15.6 0.0 5.0 4 1 1 5 5 5 3 Ankyrin repeat aGPT-Pplase1 PF18723.1 EFO63299.1 - 0.031 13.7 0.5 0.057 12.9 0.5 1.3 1 0 0 1 1 1 0 alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 1 Csm1_N PF18504.1 EFO63299.1 - 0.12 12.7 18.1 1.2 9.5 0.2 4.3 3 1 1 4 4 4 0 Csm1 N-terminal domain Fez1 PF06818.15 EFO63299.1 - 0.21 12.0 20.7 1.5 9.2 1.7 2.6 1 1 1 2 2 2 0 Fez1 3HCDH_RFF PF18321.1 EFO63299.1 - 0.56 10.7 2.3 1.5e+02 2.9 0.1 4.4 5 0 0 5 5 4 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain TMF_TATA_bd PF12325.8 EFO63299.1 - 1.6 9.0 24.2 5.6 7.2 2.4 3.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF641 PF04859.12 EFO63299.1 - 3.2 8.1 16.3 2.7 8.4 1.9 3.3 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) DUF4061 PF13270.6 EFO63299.1 - 3.5 8.0 14.6 1.6 9.1 4.7 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4061) ADIP PF11559.8 EFO63299.1 - 3.9 7.5 29.2 1.7 8.7 4.8 3.5 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding AAA_13 PF13166.6 EFO63299.1 - 5 5.6 19.9 5.9 5.4 5.0 2.2 1 1 1 2 2 2 0 AAA domain TMF_DNA_bd PF12329.8 EFO63299.1 - 8.8 6.4 18.6 4.1 7.5 2.7 3.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Goodbye PF17109.5 EFO63300.1 - 0.0044 17.5 0.3 0.054 13.9 0.0 2.3 2 0 0 2 2 2 1 fungal STAND N-terminal Goodbye domain Fib_alpha PF08702.10 EFO63300.1 - 0.0098 16.1 13.4 0.068 13.4 3.3 2.3 1 1 1 2 2 2 2 Fibrinogen alpha/beta chain family DUF2203 PF09969.9 EFO63300.1 - 0.03 15.0 9.0 0.22 12.2 0.2 3.1 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF4201 PF13870.6 EFO63300.1 - 0.033 13.9 10.6 0.53 10.0 0.9 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) DUF4618 PF15397.6 EFO63300.1 - 0.042 13.3 12.0 1.6 8.1 12.0 2.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) DUF4957 PF16318.5 EFO63300.1 - 0.048 13.6 0.2 0.081 12.9 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4957) UPF0449 PF15136.6 EFO63300.1 - 0.08 13.4 6.8 1.1 9.7 0.1 3.4 3 0 0 3 3 3 0 Uncharacterised protein family UPF0449 TMPIT PF07851.13 EFO63300.1 - 0.38 9.9 8.8 0.98 8.6 0.6 2.5 2 1 1 3 3 3 0 TMPIT-like protein DivIVA PF05103.13 EFO63300.1 - 0.47 10.5 12.4 3.1 7.9 1.5 3.2 3 0 0 3 3 3 0 DivIVA protein Cluap1 PF10234.9 EFO63300.1 - 0.51 9.7 13.3 0.62 9.4 2.2 2.2 1 1 0 2 2 2 0 Clusterin-associated protein-1 Uso1_p115_C PF04871.13 EFO63300.1 - 0.53 10.7 12.7 0.62 10.4 2.0 2.3 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Spc7 PF08317.11 EFO63300.1 - 0.81 8.5 14.5 1.4 7.7 3.3 2.1 1 1 0 2 2 2 0 Spc7 kinetochore protein DUF4407 PF14362.6 EFO63300.1 - 0.97 8.7 10.7 0.6 9.4 0.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF3450 PF11932.8 EFO63300.1 - 0.98 8.7 11.1 2.5 7.3 0.4 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 EFO63300.1 - 1.9 8.5 10.5 3.3 7.8 0.9 3.0 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) DivIC PF04977.15 EFO63300.1 - 2.4 8.0 9.9 17 5.3 2.7 3.3 3 0 0 3 3 3 0 Septum formation initiator Syntaxin-6_N PF09177.11 EFO63300.1 - 2.6 8.7 11.4 0.87 10.2 0.9 3.2 1 1 0 2 2 2 0 Syntaxin 6, N-terminal CREPT PF16566.5 EFO63300.1 - 3.2 7.9 8.9 2.1 8.5 0.3 2.7 3 1 0 3 3 2 0 Cell-cycle alteration and expression-elevated protein in tumour HisKA_3 PF07730.13 EFO63300.1 - 3.8 8.1 12.0 6 7.5 2.1 3.2 3 0 0 3 3 3 0 Histidine kinase Ank_2 PF12796.7 EFO63301.1 - 2.4e-83 274.8 30.2 1.6e-15 57.5 0.9 7.3 1 1 6 8 8 8 8 Ankyrin repeats (3 copies) Ank PF00023.30 EFO63301.1 - 5.8e-48 159.3 10.4 0.00044 20.6 0.0 12.5 11 2 1 12 12 12 10 Ankyrin repeat Ank_4 PF13637.6 EFO63301.1 - 7.5e-43 144.4 8.4 1.2e-08 35.3 0.0 8.8 6 2 4 10 10 10 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63301.1 - 1.1e-37 123.7 7.2 0.00023 21.3 0.0 12.2 12 0 0 12 12 12 10 Ankyrin repeat Ank_5 PF13857.6 EFO63301.1 - 1.2e-36 124.3 11.2 6.9e-07 29.4 0.0 10.4 2 2 10 12 12 12 9 Ankyrin repeats (many copies) DUF1847 PF08901.11 EFO63301.1 - 0.028 14.1 0.1 0.058 13.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1847) PP2C PF00481.21 EFO63301.1 - 0.061 12.9 1.8 17 4.9 0.1 3.5 2 2 1 4 4 4 0 Protein phosphatase 2C NifU PF01106.17 EFO63302.1 - 1.1e-14 54.3 0.0 3.2e-14 52.8 0.0 1.8 2 0 0 2 2 2 1 NifU-like domain Nfu_N PF08712.11 EFO63302.1 - 0.0039 17.2 0.0 0.0095 16.0 0.0 1.6 1 1 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal Sfi1 PF08457.10 EFO63303.1 - 1.4e-07 30.4 95.4 3.6e-05 22.5 5.6 8.2 4 3 3 8 8 8 7 Sfi1 spindle body protein Pkinase PF00069.25 EFO63304.1 - 5.2e-66 222.7 0.4 6.8e-66 222.3 0.4 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63304.1 - 1.5e-45 155.5 0.1 2.2e-45 154.9 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFO63304.1 - 1.5e-06 27.2 0.0 2.6e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFO63304.1 - 4.2e-06 26.3 0.0 1.6e-05 24.4 0.0 1.9 2 0 0 2 2 2 1 Kinase-like DUF3552 PF12072.8 EFO63304.1 - 0.0098 15.3 1.6 0.0098 15.3 1.6 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3552) APH PF01636.23 EFO63304.1 - 0.19 11.6 2.6 0.74 9.7 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family FliG_N PF14842.6 EFO63304.1 - 1.1 9.8 3.9 2.9 8.5 0.2 2.4 2 0 0 2 2 2 0 FliG N-terminal domain CAP_GLY PF01302.25 EFO63305.1 - 1.8e-17 63.1 0.2 1.8e-17 63.1 0.2 2.2 3 0 0 3 3 3 1 CAP-Gly domain Ubiquitin_2 PF14560.6 EFO63305.1 - 5.8e-16 58.7 1.2 9.6e-16 58.0 0.1 1.8 2 0 0 2 2 2 1 Ubiquitin-like domain ubiquitin PF00240.23 EFO63305.1 - 0.0097 15.6 0.1 0.026 14.3 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin family DUF374 PF04028.13 EFO63305.1 - 0.031 13.8 0.1 0.054 13.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF374) Retrotran_gag_2 PF14223.6 EFO63305.1 - 0.041 13.5 0.1 0.092 12.4 0.1 1.5 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type VSP PF03302.13 EFO63306.1 - 3.6e-159 529.8 165.5 4e-146 486.9 112.5 4.2 1 1 3 4 4 4 2 Giardia variant-specific surface protein Exo_endo_phos PF03372.23 EFO63307.1 - 7.6e-08 32.2 0.0 1.1e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ephrin_rec_like PF07699.13 EFO63308.1 - 3.8e-19 68.2 23.0 9e-16 57.4 4.4 3.6 2 1 1 3 3 3 3 Putative ephrin-receptor like DUF2318 PF10080.9 EFO63308.1 - 0.75 9.9 12.8 0.057 13.5 1.2 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) DER1 PF04511.15 EFO63309.1 - 0.089 12.7 3.3 0.16 11.9 3.3 1.6 1 1 0 1 1 1 0 Der1-like family Dec-1 PF04624.14 EFO63309.1 - 2.9 7.8 5.6 4.7 7.1 5.6 1.2 1 0 0 1 1 1 0 Dec-1 repeat Pox_F15 PF04596.12 EFO63310.1 - 0.038 13.7 0.1 0.1 12.4 0.1 1.7 1 0 0 1 1 1 0 Poxvirus protein F15 Bromodomain PF00439.25 EFO63311.1 - 0.0082 16.2 0.0 0.024 14.7 0.0 1.8 1 0 0 1 1 1 1 Bromodomain WD40 PF00400.32 EFO63311.1 - 0.06 14.3 1.1 1.6 9.8 0.1 3.4 2 0 0 2 2 2 0 WD domain, G-beta repeat HECW_N PF16562.5 EFO63311.1 - 0.12 12.2 0.2 0.42 10.4 0.1 2.0 2 0 0 2 2 2 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 SspB PF04386.13 EFO63311.1 - 0.46 10.4 6.6 0.086 12.7 0.4 2.4 2 0 0 2 2 2 0 Stringent starvation protein B ANAPC4_WD40 PF12894.7 EFO63312.1 - 0.00038 20.7 0.0 1.9 8.8 0.0 3.1 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain TPR_1 PF00515.28 EFO63313.1 - 1e-12 47.3 0.1 0.0013 18.4 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFO63313.1 - 1.5e-10 40.3 0.1 0.032 14.3 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFO63313.1 - 1.3e-07 31.3 0.0 0.093 13.0 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFO63313.1 - 1.4e-07 31.1 0.3 0.0091 15.7 0.0 3.2 3 0 0 3 3 3 2 TPR repeat TPR_12 PF13424.6 EFO63313.1 - 4.7e-05 23.6 0.0 0.023 15.0 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFO63313.1 - 0.00065 20.3 0.0 0.008 16.8 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFO63313.1 - 0.00081 19.9 0.0 17 6.3 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFO63313.1 - 0.0014 19.2 0.0 9.4 7.4 0.0 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFO63313.1 - 0.0055 17.2 0.0 0.91 10.1 0.0 2.3 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EFO63313.1 - 0.015 14.7 0.0 0.016 14.6 0.0 1.1 1 0 0 1 1 1 0 MalT-like TPR region ANAPC3 PF12895.7 EFO63313.1 - 0.025 14.8 0.0 0.059 13.6 0.0 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Chal_sti_synt_C PF02797.15 EFO63313.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Chalcone and stilbene synthases, C-terminal domain U1snRNP70_N PF12220.8 EFO63314.1 - 7.8 7.2 8.5 1.6 9.4 0.1 3.2 4 0 0 4 4 4 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal PI3_PI4_kinase PF00454.27 EFO63315.1 - 8e-24 84.8 0.0 1.4e-21 77.4 0.0 2.9 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Sas10_Utp3 PF04000.15 EFO63315.1 - 1.2 9.8 5.1 4.5 8.0 0.1 3.7 3 0 0 3 3 3 0 Sas10/Utp3/C1D family Kinesin PF00225.23 EFO63316.1 - 1.9e-100 336.0 0.0 4.8e-100 334.7 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFO63316.1 - 1.3e-42 145.3 0.0 4.6e-42 143.5 0.0 2.0 1 0 0 1 1 1 1 Microtubule binding Leu_zip PF15294.6 EFO63316.1 - 0.012 15.1 4.2 0.012 15.1 4.2 2.9 2 1 1 3 3 3 0 Leucine zipper DivIC PF04977.15 EFO63316.1 - 0.013 15.2 1.4 0.013 15.2 1.4 3.6 2 1 1 4 4 4 0 Septum formation initiator TSC22 PF01166.18 EFO63316.1 - 0.052 13.9 4.9 0.085 13.2 0.9 3.1 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF1492 PF07374.11 EFO63316.1 - 0.11 12.7 1.5 0.31 11.2 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1492) Spc7 PF08317.11 EFO63316.1 - 0.12 11.3 15.8 0.0065 15.4 10.2 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein bZIP_1 PF00170.21 EFO63316.1 - 0.43 10.7 7.2 0.76 9.9 0.8 3.1 2 0 0 2 2 2 0 bZIP transcription factor GAS PF13851.6 EFO63316.1 - 0.6 9.4 18.7 2.4 7.5 6.2 2.7 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding YabA PF06156.13 EFO63316.1 - 2 9.1 16.6 24 5.6 6.0 4.4 3 1 2 5 5 5 0 Initiation control protein YabA GIT_CC PF16559.5 EFO63316.1 - 4.6 7.2 12.4 5.4 7.0 0.8 3.0 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF148 PF02520.17 EFO63316.1 - 7.5 6.7 14.1 7.6 6.7 0.7 3.6 2 1 1 3 3 3 0 Domain of unknown function DUF148 zf-RING_6 PF14835.6 EFO63317.1 - 4.2e-05 23.3 4.2 0.00012 21.9 4.2 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_2 PF13923.6 EFO63317.1 - 0.00024 20.9 7.4 0.00024 20.9 7.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO63317.1 - 0.00027 20.7 6.9 0.0009 19.1 6.9 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EFO63317.1 - 0.00033 20.5 8.6 0.00033 20.5 8.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFO63317.1 - 0.00041 20.2 6.8 0.00041 20.2 6.8 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFO63317.1 - 0.00098 19.1 5.9 0.00098 19.1 5.9 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFO63317.1 - 0.0032 17.3 6.3 0.0032 17.3 6.3 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) GAS PF13851.6 EFO63317.1 - 0.0053 16.1 10.1 0.0053 16.1 10.1 3.2 2 1 1 3 3 3 1 Growth-arrest specific micro-tubule binding zf-C3HC4_4 PF15227.6 EFO63317.1 - 0.011 15.9 9.7 0.011 15.9 9.7 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING ZapB PF06005.12 EFO63317.1 - 0.014 15.9 22.7 0.021 15.3 5.5 4.8 4 0 0 4 4 4 0 Cell division protein ZapB DUF2935 PF11155.8 EFO63317.1 - 0.014 15.7 1.0 12 6.3 0.0 4.1 2 2 1 3 3 3 0 Domain of unknown function (DUF2935) zf-RING_2 PF13639.6 EFO63317.1 - 0.42 11.0 11.2 0.14 12.5 7.6 2.2 2 0 0 2 2 1 0 Ring finger domain YabA PF06156.13 EFO63317.1 - 0.48 11.1 19.5 0.14 12.9 5.1 4.0 4 0 0 4 4 4 0 Initiation control protein YabA zf-C3H2C3 PF17122.5 EFO63317.1 - 1.4 9.0 5.1 4.3 7.5 5.1 1.9 1 1 0 1 1 1 0 Zinc-finger GIT_CC PF16559.5 EFO63317.1 - 3.3 7.7 7.3 2.8 7.9 1.8 3.7 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor HrpB7 PF09486.10 EFO63317.1 - 3.5 8.0 8.6 0.7 10.3 0.8 2.9 1 1 2 3 3 3 0 Bacterial type III secretion protein (HrpB7) HALZ PF02183.18 EFO63317.1 - 7.9 6.8 24.5 3.8 7.8 0.1 6.2 5 1 1 6 6 6 0 Homeobox associated leucine zipper EF-hand_6 PF13405.6 EFO63318.1 - 0.019 14.9 0.0 3.3 7.9 0.0 3.2 3 0 0 3 3 3 0 EF-hand domain EF-hand_7 PF13499.6 EFO63318.1 - 0.025 15.0 0.0 0.68 10.4 0.0 2.2 1 1 0 1 1 1 0 EF-hand domain pair DUF4600 PF15372.6 EFO63319.1 - 0.13 12.7 0.6 0.22 11.9 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) U3_assoc_6 PF08640.11 EFO63320.1 - 7.9e-13 48.3 0.6 1.7e-12 47.2 0.6 1.6 1 0 0 1 1 1 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.6 EFO63320.1 - 0.12 13.3 3.1 0.38 11.7 0.7 3.1 3 1 1 4 4 4 0 Tetratricopeptide repeat PrgI PF12666.7 EFO63321.1 - 0.026 15.3 8.0 1.6 9.5 0.0 3.6 3 1 1 4 4 4 0 PrgI family protein Pkinase PF00069.25 EFO63322.1 - 1.2e-34 119.9 0.0 2.4e-34 118.9 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63322.1 - 1.8e-20 73.3 0.0 2.4e-20 72.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFO63322.1 - 0.0011 18.9 0.1 0.0011 18.9 0.1 2.1 2 1 0 2 2 2 1 Phosphotransferase enzyme family HTH_20 PF12840.7 EFO63322.1 - 0.0081 16.2 0.8 0.022 14.8 0.8 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain Kinase-like PF14531.6 EFO63322.1 - 0.023 14.0 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like bZIP_1 PF00170.21 EFO63325.1 - 0.0048 17.0 10.8 0.082 13.0 0.7 3.1 2 1 1 3 3 3 2 bZIP transcription factor CC2-LZ PF16516.5 EFO63325.1 - 0.017 15.5 19.4 0.079 13.3 9.9 2.9 1 1 2 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DivIC PF04977.15 EFO63325.1 - 0.039 13.7 1.4 0.039 13.7 1.4 3.9 2 2 2 4 4 4 0 Septum formation initiator TACC_C PF05010.14 EFO63325.1 - 0.11 12.3 19.6 0.11 12.3 4.6 3.1 1 1 2 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Fez1 PF06818.15 EFO63325.1 - 0.29 11.6 19.1 0.63 10.5 3.9 2.1 1 1 1 2 2 2 0 Fez1 ADIP PF11559.8 EFO63325.1 - 0.49 10.5 22.4 1.9 8.5 7.0 2.3 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding YtxH PF12732.7 EFO63325.1 - 0.56 10.8 5.1 49 4.6 5.1 2.9 1 1 0 1 1 1 0 YtxH-like protein DUF948 PF06103.11 EFO63325.1 - 0.64 10.3 2.7 22 5.4 0.3 2.5 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) IZUMO PF15005.6 EFO63325.1 - 0.81 10.2 5.9 0.34 11.4 0.8 2.2 1 1 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated MtrG PF04210.13 EFO63325.1 - 0.82 9.6 4.8 2.4 8.1 0.1 2.8 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G Syntaxin-6_N PF09177.11 EFO63325.1 - 1.5 9.4 16.4 1.3 9.6 6.3 2.9 1 1 2 3 3 3 0 Syntaxin 6, N-terminal UPF0242 PF06785.11 EFO63325.1 - 1.6 8.8 23.8 2.2 8.4 8.4 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus SlyX PF04102.12 EFO63325.1 - 3 8.5 18.7 0.47 11.1 4.1 2.9 1 1 2 3 3 3 0 SlyX MPS2 PF17060.5 EFO63325.1 - 3.2 6.9 16.6 0.55 9.4 8.0 2.1 1 1 1 2 2 2 0 Monopolar spindle protein 2 Ly49 PF08391.10 EFO63325.1 - 3.4 8.1 10.5 0.61 10.5 2.7 2.3 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region Baculo_PEP_C PF04513.12 EFO63325.1 - 3.5 7.6 7.4 4.9 7.2 2.5 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FAM76 PF16046.5 EFO63325.1 - 5.3 6.3 15.1 9.7 5.4 15.1 1.4 1 1 0 1 1 1 0 FAM76 protein Cep57_CLD_2 PF14197.6 EFO63325.1 - 5.6 7.1 21.5 0.95 9.6 0.2 4.4 2 2 1 4 4 4 0 Centrosome localisation domain of PPC89 VSG_B PF13206.6 EFO63325.1 - 5.9 6.0 7.1 1.2 8.3 3.4 1.6 1 1 1 2 2 2 0 Trypanosomal VSG domain GrpE PF01025.19 EFO63325.1 - 8.9 5.9 20.8 18 4.9 9.5 2.9 1 1 0 2 2 2 0 GrpE DUF1664 PF07889.12 EFO63325.1 - 9.3 6.3 11.9 13 5.8 3.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Sld5 PF05916.11 EFO63326.1 - 1.6e-15 57.5 0.2 2.3e-15 57.0 0.2 1.2 1 0 0 1 1 1 1 GINS complex protein Mob1_phocein PF03637.17 EFO63327.1 - 2.3e-17 63.5 1.5 3.2e-17 63.1 1.5 1.2 1 0 0 1 1 1 1 Mob1/phocein family CxC6 PF18721.1 EFO63327.1 - 0.03 14.6 3.1 0.054 13.8 3.1 1.4 1 0 0 1 1 1 0 CxC6 like cysteine cluster associated with KDZ transposases IF-2B PF01008.17 EFO63328.1 - 2.8e-34 118.6 0.4 3.4e-34 118.4 0.4 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family Rabaptin PF03528.15 EFO63328.1 - 0.048 12.4 0.1 0.069 11.8 0.1 1.1 1 0 0 1 1 1 0 Rabaptin GrpE PF01025.19 EFO63329.1 - 3e-19 69.3 0.0 3.8e-19 69.0 0.0 1.1 1 0 0 1 1 1 1 GrpE ADIP PF11559.8 EFO63330.1 - 0.75 9.9 11.9 0.0078 16.3 1.9 2.5 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF724 PF05266.14 EFO63330.1 - 1.1 9.1 14.3 0.99 9.2 4.8 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF724) HAP1_N PF04849.13 EFO63330.1 - 3.8 6.6 12.2 0.0099 15.1 0.5 2.3 2 0 0 2 2 2 0 HAP1 N-terminal conserved region Proteasome PF00227.26 EFO63331.1 - 5e-33 114.2 0.0 6.2e-33 113.9 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit HTH_28 PF13518.6 EFO63333.1 - 0.023 14.8 0.6 8.7 6.6 0.1 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain CHASE3 PF05227.13 EFO63333.1 - 0.046 13.6 0.2 0.1 12.5 0.2 1.5 1 0 0 1 1 1 0 CHASE3 domain PC-Esterase PF13839.6 EFO63333.1 - 0.11 12.3 0.1 13 5.4 0.0 2.2 2 0 0 2 2 2 0 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Sec1 PF00995.23 EFO63334.1 - 7.4e-29 101.4 0.0 8.3e-28 97.9 0.0 1.9 1 1 0 1 1 1 1 Sec1 family dCMP_cyt_deam_1 PF00383.23 EFO63335.1 - 9.4e-21 73.6 0.8 1.3e-20 73.2 0.8 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFO63335.1 - 2.6e-16 59.6 0.0 3.1e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 EFO63335.1 - 3.8e-05 23.8 3.6 0.14 12.2 0.1 2.2 1 1 1 2 2 2 2 Bd3614-like deaminase SNAD4 PF18750.1 EFO63335.1 - 0.0082 16.3 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC4_like PF18774.1 EFO63335.1 - 0.014 15.4 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase DUF5479 PF17575.2 EFO63335.1 - 0.014 15.9 0.0 0.02 15.4 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5479) NAD2 PF18782.1 EFO63335.1 - 0.054 13.6 0.0 0.18 11.9 0.0 1.8 1 1 1 2 2 2 0 Novel AID APOBEC clade 2 APOBEC2 PF18772.1 EFO63335.1 - 0.055 13.5 0.0 0.085 12.9 0.0 1.3 1 0 0 1 1 1 0 APOBEC2 LAMTOR5 PF16672.5 EFO63335.1 - 0.1 12.5 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Ragulator complex protein LAMTOR5 APOBEC3 PF18771.1 EFO63335.1 - 0.11 12.6 0.0 0.16 12.1 0.0 1.2 1 0 0 1 1 1 0 APOBEC3 MAAL_N PF05034.13 EFO63336.1 - 0.38 10.4 3.0 0.32 10.6 0.1 2.3 3 0 0 3 3 3 0 Methylaspartate ammonia-lyase N-terminus Ribosomal_L7Ae PF01248.26 EFO63338.1 - 2e-24 85.1 0.1 2.5e-24 84.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EFO63338.1 - 0.0018 18.4 0.0 0.002 18.2 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 DUF3798 PF12683.7 EFO63338.1 - 0.062 12.7 0.0 0.08 12.4 0.0 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3798) YabA PF06156.13 EFO63340.1 - 0.025 15.2 6.5 0.03 15.0 4.7 1.9 2 0 0 2 2 2 0 Initiation control protein YabA Cep57_CLD_2 PF14197.6 EFO63340.1 - 0.093 12.8 7.2 0.45 10.6 7.2 2.1 1 1 0 1 1 1 0 Centrosome localisation domain of PPC89 PI3K_P85_iSH2 PF16454.5 EFO63340.1 - 0.14 11.7 5.6 0.14 11.8 1.4 2.2 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain FANCI_HD1 PF14679.6 EFO63341.1 - 0.11 12.5 0.0 13 5.8 0.0 2.7 2 0 0 2 2 2 0 FANCI helical domain 1 VacA PF02691.15 EFO63341.1 - 2.7 5.8 5.5 0.6 7.9 0.1 2.0 2 0 0 2 2 2 0 Vacuolating cyotoxin Rad52_Rad22 PF04098.15 EFO63342.1 - 6.5e-45 152.8 0.0 8.8e-45 152.4 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein P_proprotein PF01483.20 EFO63343.1 - 4.8e-15 55.3 0.0 9.9e-15 54.3 0.0 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain GPI-anchored PF10342.9 EFO63343.1 - 0.15 12.8 2.0 0.35 11.7 0.2 2.6 2 0 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Metallophos PF00149.28 EFO63344.1 - 2e-16 61.1 1.2 4.5e-15 56.7 1.2 2.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase SIR2 PF02146.17 EFO63345.1 - 3.8e-22 79.0 0.0 1.1e-21 77.6 0.0 1.7 1 1 0 1 1 1 1 Sir2 family Peptidase_C1 PF00112.23 EFO63346.1 - 4.8e-41 141.2 0.0 6.9e-41 140.7 0.0 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFO63346.1 - 0.0015 17.3 0.0 0.002 17.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase C1-like family SF3A2 PF16835.5 EFO63347.1 - 4.5e-16 59.0 0.2 1.2e-15 57.6 0.0 1.7 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EFO63347.1 - 0.00055 20.2 1.6 0.00055 20.2 1.6 1.9 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EFO63347.1 - 0.0061 16.9 0.8 0.0095 16.3 0.8 1.4 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) DUF3449 PF11931.8 EFO63347.1 - 0.018 14.9 0.4 0.026 14.3 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) DUF1178 PF06676.11 EFO63347.1 - 0.077 13.4 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) zf-C2H2_jaz PF12171.8 EFO63347.1 - 0.9 9.9 5.1 0.67 10.3 2.6 2.2 1 1 1 2 2 2 0 Zinc-finger double-stranded RNA-binding SLC35F PF06027.12 EFO63348.1 - 3.3e-28 99.1 24.4 4.1e-28 98.8 24.4 1.1 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 EFO63348.1 - 8.3e-06 25.0 10.7 8.3e-06 25.0 10.7 2.3 1 1 1 2 2 2 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 EFO63348.1 - 3.1e-05 24.2 43.9 0.019 15.1 17.7 2.6 2 1 0 2 2 2 2 EamA-like transporter family Transgly_assoc PF04226.13 EFO63348.1 - 0.0058 16.9 3.4 1.8 8.9 1.0 3.4 2 0 0 2 2 2 2 Transglycosylase associated protein TP6A_N PF04406.14 EFO63349.1 - 4.4e-09 36.2 0.0 9e-09 35.2 0.0 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase DUF2220 PF09983.9 EFO63349.1 - 0.0092 15.4 0.0 0.022 14.1 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria C-term(DUF2220) DUF2335 PF10097.9 EFO63349.1 - 0.054 13.5 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2335) tRNA_m1G_MT PF01746.21 EFO63352.1 - 6.2e-10 39.1 0.0 7.4e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase CENP-F_leu_zip PF10473.9 EFO63353.1 - 0.072 13.1 17.6 0.46 10.5 1.2 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DASH_Spc34 PF08657.10 EFO63353.1 - 0.38 10.5 9.1 0.31 10.8 0.3 2.5 2 0 0 2 2 2 0 DASH complex subunit Spc34 PI3K_P85_iSH2 PF16454.5 EFO63353.1 - 1.2 8.7 10.6 1.5 8.4 4.1 2.5 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain EMP24_GP25L PF01105.24 EFO63353.1 - 1.9 8.4 5.4 1.3 8.9 0.1 2.6 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD TPR_MLP1_2 PF07926.12 EFO63353.1 - 2 8.5 15.7 0.14 12.3 0.9 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF2730 PF10805.8 EFO63353.1 - 8.5 6.5 8.5 3.2 7.9 0.5 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) PRP1_N PF06424.12 EFO63354.1 - 0.035 14.5 0.0 0.078 13.4 0.0 1.6 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal MCM PF00493.23 EFO63355.1 - 5e-82 274.3 0.0 8.1e-82 273.7 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFO63355.1 - 1.6e-23 82.9 0.6 3e-23 82.1 0.6 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFO63355.1 - 4.3e-16 59.1 1.3 9.3e-16 58.0 1.3 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EFO63355.1 - 1e-07 31.5 0.0 6.1e-06 25.8 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_lid_2 PF17863.1 EFO63355.1 - 0.0051 16.6 1.0 0.017 15.0 1.0 1.8 1 0 0 1 1 1 1 AAA lid domain Sigma54_activat PF00158.26 EFO63355.1 - 0.012 15.3 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_5 PF07728.14 EFO63355.1 - 0.073 13.1 0.0 0.39 10.7 0.0 2.3 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF4423 PF14394.6 EFO63355.1 - 0.11 12.2 0.0 0.39 10.4 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) AAA_16 PF13191.6 EFO63355.1 - 0.33 11.3 2.1 4.5 7.6 0.0 2.9 2 1 0 3 3 3 0 AAA ATPase domain SNase PF00565.17 EFO63357.1 - 2.4e-21 76.3 0.0 9.6e-07 29.3 0.0 5.7 5 0 0 5 5 5 4 Staphylococcal nuclease homologue ATG16 PF08614.11 EFO63358.1 - 0.03 14.6 1.2 0.03 14.6 1.2 2.3 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) ZnuA PF01297.17 EFO63358.1 - 0.097 12.1 0.0 1.1 8.6 0.0 2.5 2 0 0 2 2 2 0 Zinc-uptake complex component A periplasmic PspA_IM30 PF04012.12 EFO63358.1 - 0.12 11.9 4.0 0.26 10.8 0.8 2.7 3 0 0 3 3 3 0 PspA/IM30 family TBCC_N PF16752.5 EFO63358.1 - 0.22 12.0 8.4 1.5 9.3 0.8 3.3 2 1 1 3 3 3 0 Tubulin-specific chaperone C N-terminal domain ApoLp-III PF07464.11 EFO63358.1 - 0.25 11.4 15.4 0.95 9.6 3.1 3.7 3 1 1 4 4 4 0 Apolipophorin-III precursor (apoLp-III) Ribosomal_L29 PF00831.23 EFO63358.1 - 0.27 11.2 2.4 0.47 10.4 0.4 2.5 2 0 0 2 2 2 0 Ribosomal L29 protein DUF5039 PF16442.5 EFO63358.1 - 0.46 10.0 3.1 3.5 7.1 0.4 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5039) ACOX PF01756.19 EFO63358.1 - 0.87 9.1 4.2 1.7 8.2 0.0 2.8 3 0 0 3 3 3 0 Acyl-CoA oxidase Laminin_II PF06009.12 EFO63358.1 - 0.95 9.5 6.3 7.7 6.5 0.0 3.2 3 0 0 3 3 3 0 Laminin Domain II DUF4795 PF16043.5 EFO63358.1 - 1.2 8.8 11.3 0.83 9.2 3.3 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4795) TMF_DNA_bd PF12329.8 EFO63358.1 - 3.4 7.7 13.7 0.67 10.0 3.3 3.6 4 0 0 4 4 4 0 TATA element modulatory factor 1 DNA binding UDPGP PF01704.18 EFO63359.1 - 5.3e-129 430.5 0.0 6.4e-129 430.2 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DNA_pol_E_B PF04042.16 EFO63360.1 - 1e-26 93.6 0.5 1.4e-26 93.1 0.5 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 EFO63360.1 - 3.3e-10 40.2 0.0 5.2e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain HEAT_2 PF13646.6 EFO63362.1 - 0.0071 16.7 7.4 1.1 9.7 0.1 5.2 4 1 0 5 5 5 1 HEAT repeats HEAT PF02985.22 EFO63362.1 - 0.034 14.4 8.6 81 3.9 0.0 7.3 7 0 0 7 7 7 0 HEAT repeat THP2 PF09432.10 EFO63362.1 - 0.039 14.0 0.0 0.2 11.7 0.0 2.2 3 0 0 3 3 3 0 Tho complex subunit THP2 DUF1039 PF06287.11 EFO63362.1 - 0.095 13.1 0.2 14 6.2 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1039) DUF2830 PF11125.8 EFO63362.1 - 0.11 12.5 0.2 0.58 10.2 0.2 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2830) HEAT_EZ PF13513.6 EFO63362.1 - 3.8 8.1 7.6 51 4.5 0.1 4.8 5 1 1 6 6 6 0 HEAT-like repeat Ribosomal_S27e PF01667.17 EFO63363.1 - 7.7e-17 60.7 1.8 9.4e-17 60.5 1.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 Methyltransf_4 PF02390.17 EFO63363.1 - 0.08 12.4 0.0 0.096 12.1 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase PsiE PF06146.12 EFO63364.1 - 8.2e-08 32.5 0.6 8.2e-08 32.5 0.6 2.4 2 1 1 3 3 3 1 Phosphate-starvation-inducible E Rhodanese PF00581.20 EFO63365.1 - 4.6e-13 49.6 0.0 1.7e-11 44.6 0.0 2.5 2 1 0 2 2 2 1 Rhodanese-like domain Leu_zip PF15294.6 EFO63367.1 - 0.0023 17.5 5.9 0.0023 17.5 5.9 6.7 4 1 1 6 6 6 4 Leucine zipper ATG16 PF08614.11 EFO63367.1 - 0.028 14.7 106.7 0.096 12.9 7.8 8.6 4 2 3 8 8 8 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 EFO63367.1 - 0.3 11.5 92.7 0.88 10.0 2.1 7.1 1 1 4 6 6 6 0 Fez1 Mto2_bdg PF12808.7 EFO63368.1 - 0.076 13.3 10.6 0.099 13.0 1.5 4.0 3 0 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region PKcGMP_CC PF16808.5 EFO63368.1 - 0.89 9.5 0.0 0.89 9.5 0.0 8.8 7 3 3 10 10 10 0 Coiled-coil N-terminus of cGMP-dependent protein kinase HAP1_N PF04849.13 EFO63370.1 - 0.0052 16.0 18.8 0.0052 16.0 18.8 7.8 2 2 4 7 7 7 2 HAP1 N-terminal conserved region ATG16 PF08614.11 EFO63370.1 - 0.0096 16.2 15.9 0.0096 16.2 15.9 11.3 1 1 7 10 10 10 5 Autophagy protein 16 (ATG16) ZapB PF06005.12 EFO63370.1 - 0.016 15.6 7.5 0.016 15.6 7.5 15.7 5 4 5 10 10 10 0 Cell division protein ZapB Fez1 PF06818.15 EFO63370.1 - 0.019 15.4 149.6 0.13 12.7 15.5 9.2 2 1 6 8 8 8 0 Fez1 DUF1902 PF08972.11 EFO63371.1 - 0.073 13.1 3.5 0.9 9.6 0.1 4.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1902) Tnp_22_trimer PF17489.2 EFO63371.1 - 0.12 12.4 7.7 4.7 7.3 0.6 5.1 4 0 0 4 4 4 0 L1 transposable element trimerization domain Aa_trans PF01490.18 EFO63372.1 - 2.3e-28 99.1 52.2 1.5e-17 63.4 20.9 2.5 3 0 0 3 3 3 2 Transmembrane amino acid transporter protein G0-G1_switch_2 PF15103.6 EFO63372.1 - 0.013 15.9 0.3 0.013 15.9 0.3 2.6 3 0 0 3 3 3 0 G0/G1 switch protein 2 COX7B PF05392.11 EFO63372.1 - 0.041 13.6 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 Cytochrome C oxidase chain VIIB Synaptobrevin PF00957.21 EFO63373.1 - 3.2e-13 49.3 2.1 5.1e-13 48.6 2.1 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EFO63373.1 - 8.7e-11 41.7 0.0 1.5e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Rpp20 PF12328.8 EFO63373.1 - 0.04 13.9 0.1 0.069 13.1 0.1 1.4 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P GP41 PF00517.17 EFO63373.1 - 0.05 13.5 0.2 0.082 12.8 0.2 1.4 1 0 0 1 1 1 0 Retroviral envelope protein Pro_dh PF01619.18 EFO63373.1 - 0.074 12.6 0.1 0.09 12.3 0.1 1.2 1 0 0 1 1 1 0 Proline dehydrogenase Lysozyme_like PF13702.6 EFO63373.1 - 0.26 11.0 1.7 0.4 10.4 0.9 1.7 1 1 0 1 1 1 0 Lysozyme-like Pkinase PF00069.25 EFO63374.1 - 4.9e-39 134.3 0.3 1.2e-38 133.0 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63374.1 - 2.6e-19 69.6 0.1 4.5e-19 68.8 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 EFO63374.1 - 5e-06 26.9 0.1 0.098 13.1 0.0 3.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFO63374.1 - 0.0071 15.8 0.0 0.13 11.8 0.0 2.9 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 EFO63374.1 - 0.018 14.9 0.0 1.6 8.9 0.0 3.5 3 0 0 3 3 3 0 EF-hand domain Kinase-like PF14531.6 EFO63374.1 - 0.043 13.1 0.0 0.091 12.1 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 EFO63374.1 - 0.06 12.7 0.2 0.2 11.0 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Alkyl_sulf_C PF14864.6 EFO63374.1 - 0.38 11.0 2.4 7.9 6.8 0.1 3.2 4 0 0 4 4 4 0 Alkyl sulfatase C-terminal Pkinase PF00069.25 EFO63375.1 - 1.1e-32 113.5 0.0 8.1e-26 91.0 0.0 3.2 3 2 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63375.1 - 3e-05 23.4 0.0 0.00015 21.1 0.0 2.0 2 1 0 2 2 2 1 Protein tyrosine kinase FTA2 PF13095.6 EFO63375.1 - 0.03 13.9 0.0 9.3 5.8 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 EFO63375.1 - 0.074 12.3 0.0 1.4 8.2 0.0 2.2 2 0 0 2 2 2 0 Kinase-like DUF4426 PF14467.6 EFO63376.1 - 1.1 9.2 3.8 10 6.1 0.0 3.0 3 1 1 4 4 4 0 Domain of unknown function (DUF4426) PKcGMP_CC PF16808.5 EFO63376.1 - 2.5 8.0 7.7 2 8.4 2.8 2.5 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase HOOK PF05622.12 EFO63377.1 - 0.00024 19.5 16.0 0.00024 19.5 16.0 5.1 3 1 2 5 5 5 3 HOOK protein Tropomyosin_1 PF12718.7 EFO63377.1 - 0.00083 19.5 12.2 0.00083 19.5 12.2 8.6 4 3 3 7 7 7 1 Tropomyosin like GAS PF13851.6 EFO63377.1 - 0.0039 16.6 8.1 0.0039 16.6 8.1 7.0 3 2 5 8 8 8 2 Growth-arrest specific micro-tubule binding DDE_Tnp_IS240 PF13610.6 EFO63377.1 - 0.084 13.1 3.8 7.9 6.7 0.5 3.1 2 0 0 2 2 2 0 DDE domain PTR PF12789.7 EFO63377.1 - 1.5 9.0 5.6 3.6 7.7 0.6 3.7 1 1 2 3 3 3 0 Phage tail repeat like SNARE PF05739.19 EFO63378.1 - 9.5e-14 51.1 0.0 1.8e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 EFO63378.1 - 0.0029 17.3 6.2 0.65 9.6 6.2 2.3 1 1 0 1 1 1 1 Syntaxin AAA_13 PF13166.6 EFO63378.1 - 0.021 13.5 3.8 0.027 13.1 3.8 1.1 1 0 0 1 1 1 0 AAA domain TMPIT PF07851.13 EFO63378.1 - 0.041 13.1 1.6 0.096 11.9 0.1 1.9 2 0 0 2 2 2 0 TMPIT-like protein Synaptobrevin PF00957.21 EFO63378.1 - 0.046 13.5 0.6 0.16 11.8 0.6 2.0 1 1 0 1 1 1 0 Synaptobrevin BssS PF13991.6 EFO63378.1 - 0.063 13.4 0.2 0.97 9.6 0.0 2.4 2 0 0 2 2 2 0 BssS protein family HBD PF18534.1 EFO63379.1 - 0.048 13.8 4.1 17 5.7 1.3 3.9 2 1 1 3 3 3 0 Helical bundle domain P22_AR_N PF10547.9 EFO63379.1 - 0.092 13.1 0.9 0.35 11.2 0.9 2.0 1 0 0 1 1 1 0 P22_AR N-terminal domain Aida_N PF08910.10 EFO63379.1 - 1.6 9.1 11.4 0.059 13.8 2.1 3.3 2 2 0 3 3 3 0 Aida N-terminus DUF4200 PF13863.6 EFO63380.1 - 6.8e-19 68.4 9.1 6.8e-19 68.4 9.1 3.7 4 0 0 4 4 4 1 Domain of unknown function (DUF4200) DivIC PF04977.15 EFO63380.1 - 7.5 6.4 9.8 0.35 10.7 0.3 3.3 3 0 0 3 3 3 0 Septum formation initiator Sec2p PF06428.11 EFO63381.1 - 0.055 13.5 0.4 0.055 13.5 0.4 4.2 5 0 0 5 5 5 0 GDP/GTP exchange factor Sec2p HMMR_N PF15905.5 EFO63382.1 - 0.00013 21.5 18.7 0.00013 21.5 18.7 3.3 1 1 2 3 3 3 1 Hyaluronan mediated motility receptor N-terminal Spc7 PF08317.11 EFO63382.1 - 0.00053 19.0 6.2 0.00053 19.0 6.2 5.2 1 1 5 6 6 6 3 Spc7 kinetochore protein DUF4201 PF13870.6 EFO63382.1 - 0.002 17.9 52.2 0.012 15.4 8.6 6.4 3 2 3 6 6 6 3 Domain of unknown function (DUF4201) bZIP_1 PF00170.21 EFO63382.1 - 0.0023 18.0 2.8 0.0023 18.0 2.8 6.4 5 3 4 9 9 9 1 bZIP transcription factor ATG16 PF08614.11 EFO63382.1 - 0.0059 16.9 58.4 0.016 15.4 5.8 5.5 1 1 3 5 5 5 3 Autophagy protein 16 (ATG16) SOGA PF11365.8 EFO63382.1 - 0.02 16.0 4.2 0.02 16.0 4.2 5.5 1 1 4 6 6 6 0 Protein SOGA CCDC92 PF14916.6 EFO63382.1 - 0.043 13.6 1.6 5 7.0 0.3 3.6 2 0 0 2 2 2 0 Coiled-coil domain of unknown function DUF1189 PF06691.11 EFO63382.1 - 0.092 12.3 6.7 0.19 11.3 6.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) DUF4639 PF15479.6 EFO63382.1 - 0.51 9.2 16.5 0.0043 16.1 8.4 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4639) Fez1 PF06818.15 EFO63382.1 - 1 9.8 53.0 0.054 13.9 16.4 4.5 1 1 3 4 4 4 0 Fez1 Bacillus_HBL PF05791.11 EFO63382.1 - 1.1 9.1 31.0 0.39 10.5 3.1 3.9 3 1 1 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) PolyA_pol_RNAbd PF12627.7 EFO63382.1 - 1.3 8.8 4.4 1.8 8.4 0.1 3.1 3 1 1 4 4 3 0 Probable RNA and SrmB- binding site of polymerase A Lebercilin PF15619.6 EFO63382.1 - 1.4 8.5 58.8 0.21 11.2 24.5 4.4 1 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease KLRAQ PF10205.9 EFO63382.1 - 2.4 8.5 37.4 0.17 12.1 0.5 6.5 2 2 5 7 7 7 0 Predicted coiled-coil domain-containing protein TolA_bind_tri PF16331.5 EFO63382.1 - 5.4 7.2 33.0 0.048 13.7 1.4 6.0 4 2 3 7 7 7 0 TolA binding protein trimerisation SlyX PF04102.12 EFO63382.1 - 6.6 7.4 40.0 11 6.7 0.3 9.2 3 2 6 9 9 9 0 SlyX Filament PF00038.21 EFO63382.1 - 8.1 5.9 58.1 0.32 10.5 6.0 5.8 1 1 1 3 3 3 0 Intermediate filament protein E1-E2_ATPase PF00122.20 EFO63383.1 - 2.5e-19 69.5 0.0 2.5e-19 69.5 0.0 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFO63383.1 - 4.1e-07 30.5 0.0 2.4e-06 28.0 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFO63383.1 - 3e-05 23.9 0.8 0.00039 20.2 0.0 2.7 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase YoqO PF14037.6 EFO63383.1 - 1.2 9.7 10.9 0.16 12.5 2.3 2.9 2 0 0 2 2 2 0 YoqO-like protein Ank_2 PF12796.7 EFO63389.1 - 8.4e-53 176.9 14.1 4.2e-14 52.9 0.1 5.5 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO63389.1 - 2.8e-30 101.0 3.3 0.00085 19.6 0.0 9.2 9 0 0 9 9 9 6 Ankyrin repeat Ank PF00023.30 EFO63389.1 - 2.4e-28 97.3 1.5 0.00092 19.6 0.0 9.2 8 1 1 9 9 9 6 Ankyrin repeat Ank_4 PF13637.6 EFO63389.1 - 9.6e-27 93.0 2.8 2.6e-05 24.7 0.0 6.9 3 2 3 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO63389.1 - 5e-26 90.4 7.2 1.4e-05 25.2 0.0 6.6 3 2 4 7 7 7 6 Ankyrin repeats (many copies) HMMR_N PF15905.5 EFO63389.1 - 0.0037 16.8 0.6 0.0064 16.0 0.6 1.3 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal Fez1 PF06818.15 EFO63389.1 - 0.0052 17.3 0.9 0.014 15.9 0.2 1.9 2 0 0 2 2 2 1 Fez1 FAM76 PF16046.5 EFO63389.1 - 0.0091 15.4 0.5 0.014 14.8 0.5 1.2 1 0 0 1 1 1 1 FAM76 protein Agglutinin PF07468.11 EFO63389.1 - 0.019 15.2 0.2 0.041 14.1 0.2 1.5 1 0 0 1 1 1 0 Agglutinin domain Bap31_Bap29_C PF18035.1 EFO63389.1 - 0.028 14.4 0.8 0.086 12.9 0.8 1.8 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain Vip3A_N PF12495.8 EFO63389.1 - 0.032 14.1 0.3 0.064 13.1 0.3 1.5 1 0 0 1 1 1 0 Vegetative insecticide protein 3A N terminal ORF_2_N PF18492.1 EFO63389.1 - 0.086 13.0 3.1 7.1 6.9 0.0 3.8 4 0 0 4 4 4 0 Open reading frame 2 N-terminal domain Lzipper-MIP1 PF14389.6 EFO63389.1 - 0.11 12.8 0.2 0.75 10.1 0.1 2.5 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Csm1_N PF18504.1 EFO63389.1 - 0.11 12.8 0.3 0.29 11.5 0.3 1.6 1 0 0 1 1 1 0 Csm1 N-terminal domain Spc7 PF08317.11 EFO63389.1 - 0.18 10.6 2.0 0.28 10.0 2.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Helicase_C PF00271.31 EFO63390.1 - 2.1e-11 44.1 0.0 4.6e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFO63390.1 - 0.0078 16.0 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Peptidase_C1 PF00112.23 EFO63391.1 - 2.6e-31 109.4 0.6 5.5e-19 69.1 0.9 3.3 3 0 0 3 3 3 3 Papain family cysteine protease EGF_2 PF07974.13 EFO63392.1 - 8.8e-27 93.2 314.7 0.0003 21.1 7.2 25.7 24 2 2 26 26 26 19 EGF-like domain EGF PF00008.27 EFO63392.1 - 9.8e-05 22.6 22.4 0.00045 20.5 1.2 27.0 27 0 0 27 27 27 12 EGF-like domain Plasmod_Pvs28 PF06247.11 EFO63392.1 - 0.0041 17.4 0.3 0.0041 17.4 0.3 21.2 23 1 0 23 23 23 6 Pvs28 EGF domain hEGF PF12661.7 EFO63392.1 - 0.008 16.8 6.4 0.008 16.8 6.4 27.7 27 1 1 28 28 28 7 Human growth factor-like EGF EGF_3 PF12947.7 EFO63392.1 - 0.027 14.7 0.7 0.027 14.7 0.7 24.3 24 0 0 24 24 24 0 EGF domain tRNA-synt_2 PF00152.20 EFO63393.1 - 5.1e-83 278.7 0.0 7.7e-83 278.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFO63393.1 - 5.5e-09 35.9 0.0 9.4e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Aminotran_1_2 PF00155.21 EFO63394.1 - 7.4e-45 153.7 0.0 1e-44 153.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EFO63394.1 - 0.0013 17.7 0.0 0.0021 17.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V CTP_transf_like PF01467.26 EFO63395.1 - 1.2e-07 32.0 0.0 2.2e-06 27.9 0.0 2.1 1 1 0 1 1 1 1 Cytidylyltransferase-like FAD_syn PF06574.12 EFO63395.1 - 0.029 14.3 0.3 0.076 12.9 0.2 1.6 2 0 0 2 2 2 0 FAD synthetase Dynamin_M PF01031.20 EFO63396.1 - 1.9e-84 283.3 0.4 3.5e-84 282.4 0.4 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EFO63396.1 - 4.7e-43 147.2 0.0 7.1e-43 146.6 0.0 1.3 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EFO63396.1 - 8.6e-22 77.1 0.3 2.1e-21 75.9 0.3 1.7 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EFO63396.1 - 2.2e-05 24.5 0.0 9.3e-05 22.5 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase DDDD PF10161.9 EFO63400.1 - 1.8 8.4 0.0 1.8 8.4 0.0 2.9 4 0 0 4 4 4 0 Putative mitochondrial precursor protein PhoLip_ATPase_C PF16212.5 EFO63401.1 - 7.4e-34 117.6 32.3 7.4e-34 117.6 32.3 3.1 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal E1-E2_ATPase PF00122.20 EFO63401.1 - 4.9e-13 49.0 0.6 5.5e-12 45.6 0.0 2.9 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EFO63401.1 - 6.5e-12 46.2 0.0 2.2e-09 37.9 0.0 3.1 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase PhoLip_ATPase_N PF16209.5 EFO63401.1 - 9.8e-08 31.6 2.5 9.8e-08 31.6 2.5 2.2 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFO63401.1 - 9.8e-07 28.8 0.0 2.5e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFO63401.1 - 0.0076 16.0 3.1 0.46 10.2 0.0 3.2 3 1 1 4 4 4 2 haloacid dehalogenase-like hydrolase HTH_20 PF12840.7 EFO63402.1 - 0.0043 17.1 0.5 0.043 13.9 0.0 2.7 2 1 0 2 2 2 1 Helix-turn-helix domain Syntaxin-6_N PF09177.11 EFO63402.1 - 0.031 14.8 0.9 1 10.0 1.1 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Rrf2 PF02082.20 EFO63402.1 - 0.07 13.5 0.1 0.66 10.4 0.0 2.4 1 1 1 2 2 2 0 Transcriptional regulator DUF5304 PF17230.2 EFO63402.1 - 0.079 13.2 0.3 0.15 12.3 0.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5304) KfrA_N PF11740.8 EFO63402.1 - 0.11 13.2 2.2 1.2 9.9 2.2 2.1 1 1 0 1 1 1 0 Plasmid replication region DNA-binding N-term ZNRF_3_ecto PF18212.1 EFO63404.1 - 0.014 15.4 0.0 0.016 15.2 0.0 1.1 1 0 0 1 1 1 0 ZNRF-3 Ectodomain Rnk_N PF14760.6 EFO63404.1 - 0.018 15.5 0.0 0.03 14.8 0.0 1.3 1 0 0 1 1 1 0 Rnk N-terminus SM-ATX PF14438.6 EFO63404.1 - 0.046 13.8 0.0 0.051 13.7 0.0 1.1 1 0 0 1 1 1 0 Ataxin 2 SM domain LSM PF01423.22 EFO63404.1 - 0.11 12.2 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 LSM domain WD40 PF00400.32 EFO63405.1 - 3.6e-08 33.9 2.5 0.061 14.2 0.0 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO63405.1 - 0.00034 20.8 0.0 0.83 10.0 0.0 3.8 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFO63405.1 - 0.00097 18.2 0.5 0.2 10.6 0.0 2.6 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein MBT PF02820.18 EFO63405.1 - 0.15 12.4 0.0 0.39 11.1 0.0 1.7 1 0 0 1 1 1 0 mbt repeat X PF00739.19 EFO63407.1 - 0.024 14.7 5.4 0.024 14.7 5.4 2.4 3 0 0 3 3 3 0 Trans-activation protein X VSP PF03302.13 EFO63408.1 - 2.3e-26 92.6 106.5 4.5e-18 65.3 46.6 3.9 1 1 1 2 2 2 2 Giardia variant-specific surface protein AAA_28 PF13521.6 EFO63409.1 - 0.00032 21.0 0.0 0.00074 19.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain PriCT_1 PF08708.11 EFO63409.1 - 0.14 11.9 0.0 0.36 10.6 0.0 1.7 1 0 0 1 1 1 0 Primase C terminal 1 (PriCT-1) NPV_P10 PF05531.12 EFO63409.1 - 6.3 7.3 6.8 1.5e+02 2.9 0.0 4.7 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein PNP_UDP_1 PF01048.20 EFO63410.1 - 7.8e-41 139.9 0.1 8.7e-41 139.7 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Gpi1 PF05024.15 EFO63411.1 - 0.045 13.8 1.3 0.065 13.3 1.3 1.4 1 0 0 1 1 1 0 N-acetylglucosaminyl transferase component (Gpi1) Clathrin PF00637.20 EFO63412.1 - 1.5e-82 274.5 2.0 5.3e-33 113.9 0.1 8.5 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 EFO63412.1 - 3.3e-13 49.3 0.1 4.2e-12 45.8 0.0 2.7 2 0 0 2 2 2 1 Clathrin-H-link TPR_14 PF13428.6 EFO63412.1 - 0.024 15.4 0.2 2.3e+02 3.0 0.0 5.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 EFO63412.1 - 0.028 13.5 0.3 0.068 12.2 0.2 1.6 2 0 0 2 2 2 0 Coatomer WD associated region Kinesin PF00225.23 EFO63414.1 - 8.5e-06 24.9 0.1 1.3e-05 24.3 0.1 1.3 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 EFO63414.1 - 0.004 17.3 4.0 0.13 12.4 1.0 2.5 1 1 1 2 2 2 2 Kinesin-associated FHA PF00498.26 EFO63414.1 - 0.0058 16.9 0.0 0.017 15.4 0.0 1.9 2 0 0 2 2 2 1 FHA domain LMP PF04778.12 EFO63414.1 - 0.042 13.8 0.7 0.091 12.7 0.7 1.6 1 0 0 1 1 1 0 LMP repeated region DUF87 PF01935.17 EFO63414.1 - 0.042 13.9 0.7 0.12 12.5 0.7 1.7 1 0 0 1 1 1 0 Helicase HerA, central domain DUF5051 PF16473.5 EFO63414.1 - 0.15 12.0 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 3' exoribonuclease, RNase T-like XhlA PF10779.9 EFO63414.1 - 7.8 6.8 9.7 5 7.4 2.8 2.6 2 0 0 2 2 2 0 Haemolysin XhlA ABC_tran_CTD PF16326.5 EFO63414.1 - 7.9 6.8 12.7 20 5.5 2.0 2.7 1 1 1 2 2 2 0 ABC transporter C-terminal domain Rpr2 PF04032.16 EFO63416.1 - 7.5e-14 51.8 4.0 9.6e-14 51.4 4.0 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain LBP_BPI_CETP PF01273.25 EFO63417.1 - 0.023 14.3 0.1 0.058 13.0 0.1 1.7 1 0 0 1 1 1 0 LBP / BPI / CETP family, N-terminal domain PSI_PsaE PF02427.17 EFO63417.1 - 0.097 12.4 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IV / PsaE DUF775 PF05603.12 EFO63418.1 - 3e-05 23.6 0.2 0.019 14.5 0.2 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF775) TPR_1 PF00515.28 EFO63419.1 - 3e-16 58.5 4.3 7.4e-08 31.9 0.3 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFO63419.1 - 6.8e-12 44.5 5.0 1.9e-05 24.4 0.3 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFO63419.1 - 3.2e-09 36.3 1.6 3.8e-05 23.6 0.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFO63419.1 - 2.1e-07 31.0 0.8 0.0009 19.4 0.5 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFO63419.1 - 3.5e-07 30.6 2.3 0.00015 22.2 0.4 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFO63419.1 - 4.9e-07 29.9 2.6 0.00018 21.7 0.3 3.1 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFO63419.1 - 7.2e-07 29.7 5.0 0.00037 21.1 0.7 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFO63419.1 - 1.8e-06 27.5 2.2 0.00014 21.5 0.1 3.1 2 1 1 3 3 3 1 TPR repeat TPR_17 PF13431.6 EFO63419.1 - 8.7e-05 22.6 0.0 0.00058 20.1 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFO63419.1 - 0.0033 17.9 1.8 0.064 13.9 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFO63419.1 - 0.028 15.2 0.5 0.36 11.8 0.1 3.0 2 1 1 3 3 2 0 Tetratricopeptide repeat RPAP3_C PF13877.6 EFO63419.1 - 0.031 14.8 0.1 0.06 13.9 0.1 1.5 1 0 0 1 1 1 0 Potential Monad-binding region of RPAP3 TPR_7 PF13176.6 EFO63419.1 - 0.064 13.3 0.6 29 5.0 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat SNAP PF14938.6 EFO63419.1 - 2 7.7 4.4 0.51 9.7 0.1 2.1 3 0 0 3 3 3 0 Soluble NSF attachment protein, SNAP HTH_32 PF13565.6 EFO63420.1 - 9.5e-05 22.9 0.0 0.012 16.2 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain PAX PF00292.18 EFO63420.1 - 0.00017 21.5 0.2 0.00031 20.7 0.2 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_29 PF13551.6 EFO63420.1 - 0.00086 19.3 0.0 0.0019 18.2 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix Pkinase PF00069.25 EFO63422.1 - 3.4e-34 118.4 0.0 4.4e-34 118.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63422.1 - 1.5e-13 50.6 0.0 4.9e-13 49.0 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO63422.1 - 0.0038 16.6 0.0 0.0071 15.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like AAA_16 PF13191.6 EFO63424.1 - 0.022 15.1 0.0 0.11 12.9 0.0 2.1 1 1 0 1 1 1 0 AAA ATPase domain DUF1515 PF07439.11 EFO63426.1 - 0.98 9.5 3.1 2.9 7.9 0.4 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1515) FAM76 PF16046.5 EFO63426.1 - 3.1 7.1 14.8 0.51 9.7 2.1 2.2 2 0 0 2 2 2 0 FAM76 protein DUF724 PF05266.14 EFO63426.1 - 3.6 7.4 7.6 2 8.2 0.3 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF724) Gp_dh_C PF02800.20 EFO63427.1 - 1.7e-66 222.7 0.0 4e-66 221.5 0.0 1.6 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EFO63427.1 - 4.6e-39 132.8 0.1 1.7e-38 131.0 0.1 2.0 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Ank_4 PF13637.6 EFO63428.1 - 2.2e-19 69.6 1.5 5.5e-10 39.6 0.3 2.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFO63428.1 - 2.6e-16 60.0 0.1 4.4e-16 59.2 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO63428.1 - 3.8e-15 54.5 0.9 9.1e-07 28.7 0.1 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EFO63428.1 - 3.5e-12 46.3 0.0 1.1e-08 35.2 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO63428.1 - 1.4e-09 38.0 1.1 6.1e-06 26.4 0.3 3.8 4 0 0 4 4 4 1 Ankyrin repeat Bromodomain PF00439.25 EFO63429.1 - 9.1e-18 64.1 0.0 3.5e-17 62.3 0.0 2.0 2 0 0 2 2 2 1 Bromodomain UcrQ PF02939.16 EFO63430.1 - 0.11 12.5 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 UcrQ family SPC12 PF06645.13 EFO63433.1 - 2.6e-20 72.3 0.5 3.2e-20 72.0 0.5 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF2784 PF10861.8 EFO63433.1 - 0.039 14.0 1.6 0.051 13.6 1.6 1.1 1 0 0 1 1 1 0 Protein of Unknown function (DUF2784) DUF3309 PF11752.8 EFO63433.1 - 0.24 11.5 4.4 10 6.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3309) Phage_holin_2_4 PF16082.5 EFO63433.1 - 0.31 10.8 1.5 2.5 7.9 0.3 2.0 1 1 1 2 2 2 0 Bacteriophage holin family, superfamily II-like Metallophos PF00149.28 EFO63434.1 - 0.0066 17.0 0.0 0.023 15.2 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 EFO63434.1 - 0.012 16.1 1.0 0.057 14.0 1.0 2.1 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain fn3 PF00041.21 EFO63434.1 - 0.041 14.2 1.8 0.15 12.4 0.7 2.2 2 0 0 2 2 2 0 Fibronectin type III domain ART PF01129.18 EFO63435.1 - 0.035 13.4 0.2 0.035 13.4 0.2 3.6 3 2 0 3 3 3 0 NAD:arginine ADP-ribosyltransferase JAB PF01398.21 EFO63436.1 - 3.1e-18 65.9 0.0 6.9e-18 64.7 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease FAP206 PF12018.8 EFO63436.1 - 0.051 13.1 0.0 0.063 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function TcdA_TcdB PF12919.7 EFO63436.1 - 0.058 12.7 0.1 0.076 12.3 0.1 1.1 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Csm1_N PF18504.1 EFO63439.1 - 0.026 14.9 0.0 0.026 14.9 0.0 4.0 3 1 0 4 4 4 0 Csm1 N-terminal domain Med9 PF07544.13 EFO63439.1 - 0.027 14.5 6.1 0.96 9.6 0.1 2.9 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 bZIP_2 PF07716.15 EFO63439.1 - 0.075 13.1 8.1 1.8 8.7 0.6 3.5 3 0 0 3 3 3 0 Basic region leucine zipper Pox_A3L PF05288.11 EFO63439.1 - 0.12 12.4 0.2 0.41 10.7 0.0 2.0 2 0 0 2 2 2 0 Poxvirus A3L Protein DUF5486 PF17588.2 EFO63439.1 - 0.14 12.0 0.0 0.41 10.6 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5486) SlyX PF04102.12 EFO63439.1 - 1.3 9.7 0.0 1.3 9.7 0.0 3.2 3 1 0 3 3 3 0 SlyX HALZ PF02183.18 EFO63439.1 - 1.3 9.3 4.5 5.7 7.2 0.2 3.5 3 0 0 3 3 3 0 Homeobox associated leucine zipper TMF_TATA_bd PF12325.8 EFO63439.1 - 6.7 7.0 14.2 5.5 7.2 4.0 3.8 3 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding SNF2_N PF00176.23 EFO63440.1 - 8.1e-37 126.7 2.4 4.9e-20 71.5 0.0 3.2 3 0 0 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EFO63440.1 - 3.3e-17 62.8 0.2 1.8e-15 57.2 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFO63440.1 - 0.003 17.3 0.0 0.016 14.9 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_RecD PF05127.14 EFO63440.1 - 0.0062 16.4 0.0 0.17 11.7 0.0 2.9 3 0 0 3 3 3 1 Helicase AAA_34 PF13872.6 EFO63440.1 - 0.019 13.9 0.0 0.038 12.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 Pkinase PF00069.25 EFO63441.1 - 7.9e-22 77.9 0.0 6.2e-20 71.7 0.0 3.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63441.1 - 8.2e-06 25.3 0.0 0.00024 20.5 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EFO63441.1 - 0.0032 16.9 0.0 0.006 16.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFO63441.1 - 0.014 14.2 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EFO63441.1 - 0.043 13.7 0.0 0.11 12.4 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EFO63441.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Ank_2 PF12796.7 EFO63442.1 - 6.4e-54 180.5 0.0 2.4e-20 72.9 0.1 4.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EFO63442.1 - 5.9e-37 124.5 0.0 5.4e-05 23.5 0.0 7.8 8 0 0 8 8 8 7 Ankyrin repeat Ank_4 PF13637.6 EFO63442.1 - 2.7e-36 123.5 0.1 5e-09 36.5 0.0 5.0 4 2 1 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO63442.1 - 3.1e-35 119.8 1.1 1.2e-06 28.6 0.0 7.1 2 1 5 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63442.1 - 5.3e-31 103.2 0.0 0.00023 21.3 0.0 7.9 8 0 0 8 8 8 6 Ankyrin repeat VWA_3_C PF18571.1 EFO63442.1 - 0.069 13.0 0.3 41 4.1 0.0 4.4 5 0 0 5 5 5 0 von Willebrand factor type A C-terminal domain Prp18 PF02840.15 EFO63443.1 - 7.5e-06 26.1 0.0 1e-05 25.6 0.0 1.2 1 0 0 1 1 1 1 Prp18 domain EGF PF00008.27 EFO63445.1 - 2.4e-26 91.7 136.6 3.3e-06 27.3 2.4 13.9 13 0 0 13 13 13 12 EGF-like domain EGF_2 PF07974.13 EFO63445.1 - 1.7e-21 76.2 164.1 0.00044 20.6 6.1 13.6 12 1 0 12 12 12 12 EGF-like domain hEGF PF12661.7 EFO63445.1 - 0.33 11.6 130.3 0.054 14.2 3.8 15.3 14 2 0 14 14 14 0 Human growth factor-like EGF DUF1192 PF06698.11 EFO63447.1 - 0.11 12.5 2.0 0.29 11.2 2.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) E2F_TDP PF02319.20 EFO63448.1 - 1.4e-06 28.2 0.0 3.6e-06 26.9 0.0 1.7 2 0 0 2 2 2 1 E2F/DP family winged-helix DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFO63449.1 - 0.0072 16.5 0.1 0.012 15.8 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Acyltransferase PF01553.21 EFO63451.1 - 2.4e-08 33.7 0.0 5.3e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Metallophos PF00149.28 EFO63452.1 - 1.3e-23 84.6 0.2 2.1e-23 83.9 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase WBS_methylT PF12589.8 EFO63453.1 - 1.4e-15 57.8 2.1 2.5e-15 57.0 2.1 1.4 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 EFO63453.1 - 1.8e-08 34.9 0.0 2.7e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFO63453.1 - 8.1e-08 32.9 0.0 1.7e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFO63453.1 - 2.3e-06 27.5 0.0 3.3e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFO63453.1 - 8.4e-05 22.4 0.1 0.00015 21.5 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFO63453.1 - 0.0002 22.0 0.0 0.00037 21.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFO63453.1 - 0.0075 16.0 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) AdoMet_MTase PF07757.13 EFO63453.1 - 0.025 14.9 0.0 0.059 13.7 0.0 1.7 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase TPMT PF05724.11 EFO63453.1 - 0.031 13.9 0.0 0.044 13.4 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_16 PF10294.9 EFO63453.1 - 0.078 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_32 PF13679.6 EFO63453.1 - 0.1 12.6 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 EFO63453.1 - 0.11 12.1 0.0 0.28 10.7 0.0 1.6 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW PrmA PF06325.13 EFO63453.1 - 0.13 11.6 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) N6_N4_Mtase PF01555.18 EFO63453.1 - 0.13 11.9 0.0 0.51 10.0 0.0 1.8 2 0 0 2 2 2 0 DNA methylase TehB PF03848.14 EFO63453.1 - 0.22 10.9 0.0 0.46 9.9 0.0 1.4 1 1 0 1 1 1 0 Tellurite resistance protein TehB AAA PF00004.29 EFO63454.1 - 1.3e-39 135.7 0.1 3.9e-39 134.1 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MIT PF04212.18 EFO63454.1 - 2.1e-15 56.5 0.8 2.1e-15 56.5 0.8 2.4 3 0 0 3 3 1 1 MIT (microtubule interacting and transport) domain Vps4_C PF09336.10 EFO63454.1 - 2.9e-11 43.2 0.1 9.5e-11 41.5 0.0 2.0 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EFO63454.1 - 9.7e-08 31.7 0.1 5.8e-07 29.2 0.0 2.4 2 0 0 2 2 2 1 AAA+ lid domain RuvB_N PF05496.12 EFO63454.1 - 7.2e-07 29.1 0.0 7.5e-06 25.8 0.0 2.4 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFO63454.1 - 1.1e-05 25.9 0.1 0.029 14.7 0.0 2.7 1 1 1 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EFO63454.1 - 1.4e-05 25.4 0.3 0.025 14.9 0.1 2.6 1 1 1 2 2 2 2 AAA domain AAA_2 PF07724.14 EFO63454.1 - 0.00034 20.8 0.0 0.00069 19.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 EFO63454.1 - 0.0006 19.9 0.0 0.0014 18.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 EFO63454.1 - 0.00069 18.8 0.0 0.0013 18.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EFO63454.1 - 0.0008 19.4 0.1 0.0095 15.9 0.1 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EFO63454.1 - 0.0011 19.1 0.0 0.0031 17.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 EFO63454.1 - 0.0014 17.9 0.0 0.0023 17.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 EFO63454.1 - 0.0015 19.1 0.0 0.0047 17.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EFO63454.1 - 0.0028 17.4 0.0 0.0062 16.3 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_17 PF13207.6 EFO63454.1 - 0.0035 17.8 1.4 0.057 13.9 0.0 3.2 4 0 0 4 4 4 1 AAA domain AAA_25 PF13481.6 EFO63454.1 - 0.014 15.0 0.7 0.72 9.4 0.1 2.4 1 1 1 2 2 2 0 AAA domain Torsin PF06309.11 EFO63454.1 - 0.026 14.6 0.0 0.058 13.5 0.0 1.5 1 0 0 1 1 1 0 Torsin AAA_28 PF13521.6 EFO63454.1 - 0.038 14.2 0.0 0.086 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain TelA PF05816.11 EFO63454.1 - 0.054 12.6 0.0 0.087 11.9 0.0 1.2 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) AAA_24 PF13479.6 EFO63454.1 - 0.073 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zot PF05707.12 EFO63454.1 - 0.085 12.5 0.0 0.28 10.8 0.0 1.8 1 1 1 2 2 2 0 Zonular occludens toxin (Zot) DUF2075 PF09848.9 EFO63454.1 - 0.12 11.6 0.0 0.24 10.6 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 EFO63454.1 - 0.13 12.7 0.0 0.36 11.2 0.0 1.9 1 1 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 EFO63454.1 - 0.13 11.7 0.0 0.84 9.1 0.0 2.3 2 1 0 2 2 2 0 P-loop containing dynein motor region ATPase PF06745.13 EFO63454.1 - 0.17 11.2 1.0 5.4 6.3 0.0 2.8 2 1 0 3 3 3 0 KaiC ATS PF15445.6 EFO63455.1 - 0.00071 19.1 0.0 0.001 18.6 0.0 1.2 1 0 0 1 1 1 1 acidic terminal segments, variant surface antigen of PfEMP1 Phi-29_GP16_7 PF06720.11 EFO63455.1 - 0.012 15.5 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage phi-29 early protein GP16.7 ABC_tran PF00005.27 EFO63456.1 - 7.9e-43 146.3 0.0 3.4e-26 92.4 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFO63456.1 - 3.1e-21 76.2 47.4 1.6e-10 41.1 23.1 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EFO63456.1 - 3.3e-10 39.8 6.5 0.00011 21.7 0.3 4.2 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFO63456.1 - 4.4e-06 26.3 0.5 0.0023 17.6 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EFO63456.1 - 1.9e-05 24.7 1.1 0.033 14.3 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFO63456.1 - 7.5e-05 22.9 3.0 0.091 12.8 0.2 2.6 2 0 0 2 2 2 2 Dynamin family AAA_21 PF13304.6 EFO63456.1 - 0.00011 22.2 5.3 1.6 8.5 0.1 4.3 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFO63456.1 - 0.00018 21.4 0.1 0.4 10.6 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EFO63456.1 - 0.00019 21.8 0.5 0.063 13.7 0.1 2.6 2 0 0 2 2 2 1 AAA ATPase domain AIG1 PF04548.16 EFO63456.1 - 0.00037 19.9 1.0 0.2 10.9 0.0 2.6 2 0 0 2 2 2 2 AIG1 family T2SSE PF00437.20 EFO63456.1 - 0.0028 16.8 0.2 0.55 9.2 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein IIGP PF05049.13 EFO63456.1 - 0.0093 15.1 0.0 0.02 14.0 0.0 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) TED PF08341.11 EFO63456.1 - 0.01 16.2 0.2 0.089 13.2 0.0 2.2 2 0 0 2 2 2 1 Thioester domain AAA_23 PF13476.6 EFO63456.1 - 0.022 15.2 0.5 0.78 10.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 EFO63456.1 - 0.029 14.5 0.1 0.029 14.5 0.1 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_7 PF12775.7 EFO63456.1 - 0.032 13.8 0.1 0.18 11.3 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 EFO63456.1 - 0.061 13.6 1.0 0.38 11.0 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EFO63456.1 - 0.067 12.8 0.3 5.4 6.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EFO63456.1 - 0.094 11.9 0.2 1.1 8.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) cobW PF02492.19 EFO63456.1 - 0.1 12.2 1.5 7 6.2 0.3 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 EFO63456.1 - 0.13 11.6 3.1 0.24 10.7 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family NACHT PF05729.12 EFO63456.1 - 0.14 12.1 0.3 4.9 7.0 0.0 2.8 2 0 0 2 2 2 0 NACHT domain Zeta_toxin PF06414.12 EFO63456.1 - 0.19 11.0 0.8 8.9 5.5 0.1 2.6 2 0 0 2 2 2 0 Zeta toxin DUF3951 PF13131.6 EFO63456.1 - 5 7.4 12.8 3.1 8.0 1.4 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3951) EF1G PF00647.19 EFO63458.1 - 0.079 13.0 0.1 0.099 12.7 0.1 1.2 1 0 0 1 1 1 0 Elongation factor 1 gamma, conserved domain RPN6_C_helix PF18503.1 EFO63460.1 - 0.05 13.4 0.2 0.11 12.3 0.2 1.6 1 0 0 1 1 1 0 26S proteasome subunit RPN6 C-terminal helix domain Ank_2 PF12796.7 EFO63462.1 - 6e-40 135.7 16.0 1.3e-15 57.7 0.8 2.9 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63462.1 - 8.8e-14 51.4 1.5 1.9e-05 24.8 0.1 3.4 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63462.1 - 9e-14 50.3 0.6 0.025 15.1 0.0 4.6 4 0 0 4 4 4 4 Ankyrin repeat Ank PF00023.30 EFO63462.1 - 2e-13 50.1 0.3 0.0023 18.3 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EFO63462.1 - 3.9e-10 40.1 2.4 0.0012 19.4 0.2 3.9 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Peptidase_C1 PF00112.23 EFO63463.1 - 1.9e-42 145.8 0.0 2.8e-42 145.3 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease CathepsinC_exc PF08773.11 EFO63463.1 - 4.2e-16 59.3 0.1 7.1e-16 58.6 0.1 1.3 1 0 0 1 1 1 1 Cathepsin C exclusion domain COG5 PF10392.9 EFO63464.1 - 0.066 13.4 11.6 2.4 8.3 0.6 3.1 1 1 2 3 3 3 0 Golgi transport complex subunit 5 DUF1690 PF07956.11 EFO63464.1 - 0.069 13.6 15.6 0.29 11.6 2.4 2.1 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) TMPIT PF07851.13 EFO63464.1 - 0.11 11.7 14.4 0.23 10.7 10.7 2.0 1 1 1 2 2 2 0 TMPIT-like protein SKA1 PF07160.12 EFO63464.1 - 0.24 11.2 14.3 2.2 8.1 9.7 2.0 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 IPPT PF01715.17 EFO63464.1 - 0.32 10.8 10.1 0.52 10.1 9.6 1.5 1 1 1 2 2 2 0 IPP transferase FANCI_S2 PF14676.6 EFO63464.1 - 0.33 11.3 4.3 0.73 10.1 4.0 1.6 1 1 1 2 2 2 0 FANCI solenoid 2 Exonuc_VII_L PF02601.15 EFO63464.1 - 0.68 9.4 10.7 0.88 9.1 10.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 EFO63464.1 - 0.74 9.1 19.5 1.8 7.9 19.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Snf7 PF03357.21 EFO63464.1 - 0.77 9.3 26.0 3.2 7.3 26.0 2.0 1 1 0 1 1 1 0 Snf7 TMEM215 PF15746.5 EFO63464.1 - 1.3 8.5 5.0 1.6 8.2 5.0 1.2 1 0 0 1 1 1 0 TMEM215 family DUF4200 PF13863.6 EFO63464.1 - 1.7 9.1 20.5 0.37 11.2 16.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) AAA_13 PF13166.6 EFO63464.1 - 2.3 6.7 20.0 2.2 6.8 5.3 2.0 1 1 1 2 2 2 0 AAA domain ADIP PF11559.8 EFO63464.1 - 2.4 8.2 20.1 0.6 10.2 11.8 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF948 PF06103.11 EFO63464.1 - 2.9 8.2 16.4 2.3 8.5 10.1 2.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Spectrin PF00435.21 EFO63464.1 - 3.5 8.2 13.4 1.1 9.8 7.4 2.5 1 1 2 3 3 3 0 Spectrin repeat COG2 PF06148.11 EFO63464.1 - 3.5 7.7 13.7 9.3 6.3 6.0 2.7 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 CorA PF01544.18 EFO63464.1 - 3.8 6.8 9.9 0.32 10.3 2.6 2.0 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Sec34 PF04136.15 EFO63464.1 - 4.6 7.1 13.3 5.2 6.9 4.3 2.8 1 1 1 2 2 2 0 Sec34-like family CRR7 PF12095.8 EFO63464.1 - 6.1 7.4 10.2 6.6 7.3 2.4 2.9 2 1 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 FAM76 PF16046.5 EFO63464.1 - 6.1 6.1 15.3 2 7.7 12.2 1.6 1 1 0 1 1 1 0 FAM76 protein Fib_alpha PF08702.10 EFO63464.1 - 6.2 7.0 15.5 1.8 8.7 3.6 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Mod_r PF07200.13 EFO63464.1 - 8.1 6.5 16.8 13 5.9 16.1 1.7 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DUF1664 PF07889.12 EFO63464.1 - 8.1 6.5 12.8 4.2 7.4 9.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF2203 PF09969.9 EFO63464.1 - 8.6 7.1 12.9 2.2 9.0 2.0 2.5 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) FAD-SLDH PF12318.8 EFO63464.1 - 8.7 6.4 8.3 1.2 9.2 3.1 2.0 1 1 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase ABC_tran_CTD PF16326.5 EFO63464.1 - 9.6 6.5 20.7 15 5.9 8.8 3.3 1 1 1 2 2 2 0 ABC transporter C-terminal domain SlyX PF04102.12 EFO63465.1 - 0.099 13.3 0.3 0.099 13.3 0.3 3.5 1 1 2 3 3 3 0 SlyX Allexi_40kDa PF05549.11 EFO63465.1 - 0.26 10.7 5.4 0.23 10.9 4.2 1.5 1 1 0 1 1 1 0 Allexivirus 40kDa protein SOGA PF11365.8 EFO63465.1 - 0.38 11.9 12.9 0.21 12.8 10.1 2.0 2 0 0 2 2 2 0 Protein SOGA Spore_III_AF PF09581.10 EFO63465.1 - 0.47 10.5 12.5 0.68 9.9 12.5 1.4 1 1 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) YabA PF06156.13 EFO63465.1 - 1.7 9.3 17.3 0.25 12.0 3.1 3.0 1 1 2 3 3 3 0 Initiation control protein YabA TipAS PF07739.13 EFO63465.1 - 3.2 8.3 10.0 1.6 9.3 6.8 2.1 2 1 0 2 2 2 0 TipAS antibiotic-recognition domain DUF1610 PF07754.11 EFO63466.1 - 1.2 9.2 4.5 4.2 7.4 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) Metallophos PF00149.28 EFO63467.1 - 2.1e-38 132.9 0.1 2.7e-38 132.5 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFO63467.1 - 1e-14 54.6 0.1 2.1e-14 53.7 0.1 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Ank_2 PF12796.7 EFO63468.1 - 0.00053 20.5 0.0 0.0017 18.9 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Tom22 PF04281.13 EFO63468.1 - 0.078 12.8 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 baeRF_family5 PF18846.1 EFO63468.1 - 0.097 12.9 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 5 SGS PF05002.15 EFO63469.1 - 1.2e-19 70.2 0.1 1.8e-19 69.6 0.1 1.3 1 0 0 1 1 1 1 SGS domain P22_AR_N PF10547.9 EFO63469.1 - 0.11 12.8 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 P22_AR N-terminal domain RuvB_C PF05491.13 EFO63470.1 - 0.13 12.1 0.3 9.8 6.1 0.0 2.7 3 0 0 3 3 3 0 RuvB C-terminal winged helix domain PIG-X PF08320.12 EFO63472.1 - 7.2e-06 26.1 0.0 1.5e-05 25.0 0.0 1.5 1 1 0 1 1 1 1 PIG-X / PBN1 Ank_2 PF12796.7 EFO63473.1 - 1.6e-31 108.7 2.5 9.4e-09 35.8 0.1 5.6 3 2 3 6 6 6 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63473.1 - 2.2e-21 75.6 2.5 4.8e-05 23.5 0.0 6.7 5 2 1 6 6 6 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63473.1 - 9.9e-14 51.5 2.5 0.0054 17.3 0.0 6.8 5 2 1 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63473.1 - 7.4e-11 41.3 2.3 1.7 9.4 0.0 8.7 8 0 0 8 8 8 2 Ankyrin repeat Ank PF00023.30 EFO63473.1 - 1.1e-07 31.9 0.8 2.3 8.8 0.1 7.0 6 1 0 6 6 6 1 Ankyrin repeat CR6_interact PF10147.9 EFO63473.1 - 0.047 13.4 4.1 0.11 12.2 4.1 1.6 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Peptidase_C1 PF00112.23 EFO63475.1 - 9.3e-33 114.2 0.4 3.1e-32 112.4 0.4 1.8 1 1 0 1 1 1 1 Papain family cysteine protease CathepsinC_exc PF08773.11 EFO63475.1 - 1.2e-15 57.9 0.4 2.2e-15 57.0 0.4 1.5 1 0 0 1 1 1 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.15 EFO63475.1 - 0.0043 15.9 0.0 0.01 14.6 0.0 1.5 2 0 0 2 2 2 1 Peptidase C1-like family Insulin_TMD PF17870.1 EFO63475.1 - 0.033 14.3 3.8 0.073 13.1 3.8 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Sh_2 PF17512.2 EFO63475.1 - 0.1 12.4 0.3 0.54 10.0 0.1 2.0 2 0 0 2 2 2 0 Metapneumovirus Small hydrophobic protein TRP PF06011.12 EFO63475.1 - 0.19 10.4 0.5 0.29 9.8 0.5 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel Sigma_reg_N PF13800.6 EFO63475.1 - 0.22 11.8 0.5 4.7 7.6 0.3 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Endonuclease_1 PF04231.13 EFO63476.1 - 1.1e-32 113.6 0.1 1.6e-32 113.1 0.1 1.2 1 0 0 1 1 1 1 Endonuclease I DUF1524 PF07510.11 EFO63476.1 - 0.15 12.0 0.0 0.4 10.6 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1524) Prefoldin_2 PF01920.20 EFO63477.1 - 3.6e-16 59.0 8.0 4.5e-16 58.7 8.0 1.0 1 0 0 1 1 1 1 Prefoldin subunit SKA2 PF16740.5 EFO63477.1 - 0.0086 15.9 6.3 0.45 10.3 0.9 2.3 2 1 0 2 2 2 2 Spindle and kinetochore-associated protein 2 Prefoldin PF02996.17 EFO63477.1 - 0.012 15.5 4.2 0.21 11.5 1.0 2.1 2 0 0 2 2 2 0 Prefoldin subunit Spc24 PF08286.11 EFO63477.1 - 0.016 15.4 4.2 0.33 11.2 0.7 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Spc7 PF08317.11 EFO63477.1 - 0.03 13.2 4.0 0.041 12.8 4.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein FlxA PF14282.6 EFO63477.1 - 0.051 13.6 1.2 0.051 13.6 1.2 2.2 2 0 0 2 2 2 0 FlxA-like protein APG6_N PF17675.1 EFO63477.1 - 0.056 14.0 7.8 0.2 12.2 7.9 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF4795 PF16043.5 EFO63477.1 - 0.059 13.0 2.9 0.08 12.5 2.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) DUF4988 PF16378.5 EFO63477.1 - 0.06 13.0 2.9 2.3 7.8 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF4201 PF13870.6 EFO63477.1 - 0.072 12.8 6.9 0.095 12.4 1.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) NPV_P10 PF05531.12 EFO63477.1 - 0.11 13.0 5.5 0.59 10.6 1.3 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Tropomyosin_1 PF12718.7 EFO63477.1 - 0.13 12.4 6.4 0.2 11.8 6.4 1.4 1 1 0 1 1 1 0 Tropomyosin like GAS PF13851.6 EFO63477.1 - 0.4 10.0 11.4 0.45 9.8 2.6 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Laminin_II PF06009.12 EFO63477.1 - 0.69 9.9 7.2 27 4.8 7.2 2.2 1 1 0 1 1 1 0 Laminin Domain II YabA PF06156.13 EFO63477.1 - 1.2 9.8 7.9 2.4 8.8 1.1 2.1 1 1 1 2 2 2 0 Initiation control protein YabA VSP PF03302.13 EFO63480.1 - 9.5e-107 357.3 136.9 2.5e-53 181.4 30.0 5.0 1 1 4 5 5 5 5 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO63480.1 - 0.0027 17.9 2.6 0.0027 17.9 2.6 8.7 2 1 6 8 8 8 5 Furin-like repeat, cysteine-rich Podoplanin PF05808.11 EFO63480.1 - 0.069 13.2 0.7 0.14 12.2 0.1 1.8 2 0 0 2 2 2 0 Podoplanin IQ PF00612.27 EFO63481.1 - 5.1e-07 28.9 40.6 0.037 13.8 0.2 7.9 7 0 0 7 7 7 5 IQ calmodulin-binding motif LRR_9 PF14580.6 EFO63481.1 - 0.00025 20.6 0.4 0.00064 19.3 0.4 1.6 1 0 0 1 1 1 1 Leucine-rich repeat Peptidase_S66 PF02016.15 EFO63481.1 - 0.081 13.0 0.0 7.9 6.6 0.0 2.7 2 0 0 2 2 2 0 LD-carboxypeptidase N-terminal domain DUF2340 PF10209.9 EFO63481.1 - 0.18 12.3 0.8 3 8.3 0.0 2.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2340) LRR_8 PF13855.6 EFO63481.1 - 2.3 8.0 14.4 1.1 9.1 5.1 3.7 2 1 1 3 3 3 0 Leucine rich repeat DUF5532 PF17673.1 EFO63482.1 - 0.023 14.7 0.7 0.052 13.6 0.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5532) Ank_2 PF12796.7 EFO63486.1 - 4.5e-30 104.1 2.3 2.4e-15 56.9 0.2 2.5 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63486.1 - 1.2e-18 66.9 1.2 4.2e-12 46.0 0.2 3.2 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63486.1 - 1.1e-17 64.1 0.5 1.5e-14 54.1 0.2 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63486.1 - 2.4e-15 55.1 0.0 0.00073 19.8 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 EFO63486.1 - 4.1e-09 36.5 1.5 0.011 16.2 0.1 4.0 5 0 0 5 5 5 2 Ankyrin repeat DUF3718 PF12514.8 EFO63486.1 - 0.17 12.1 1.2 11 6.3 0.0 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF3718) tRNA_int_endo PF01974.17 EFO63487.1 - 2.7e-10 40.2 0.0 4.3e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 EFO63487.1 - 0.017 14.8 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 tRNA intron endonuclease, N-terminal domain Kinesin PF00225.23 EFO63488.1 - 5.5e-108 360.8 1.6 8.8e-108 360.2 1.6 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFO63488.1 - 2.2e-21 76.4 0.0 5.5e-21 75.1 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding Kinesin_assoc PF16183.5 EFO63488.1 - 0.00056 20.1 6.6 0.00088 19.5 2.2 2.9 2 1 0 2 2 2 1 Kinesin-associated FHA PF00498.26 EFO63488.1 - 0.0007 19.9 0.2 0.0065 16.8 0.0 2.7 2 0 0 2 2 2 1 FHA domain GOLGA2L5 PF15070.6 EFO63488.1 - 0.0088 14.8 2.5 0.013 14.2 2.5 1.1 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 PP1_inhibitor PF05361.12 EFO63488.1 - 0.035 14.1 0.0 0.087 12.8 0.0 1.6 1 0 0 1 1 1 0 PKC-activated protein phosphatase-1 inhibitor Thioredoxin_14 PF18402.1 EFO63488.1 - 0.056 13.4 0.2 0.53 10.2 0.0 2.5 3 0 0 3 3 3 0 Thioredoxin-like domain PDGF_N PF04692.13 EFO63488.1 - 0.059 14.2 2.2 0.14 12.9 0.1 2.5 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region rRNA_processing PF08524.11 EFO63488.1 - 1.3 9.0 5.6 4 7.4 5.6 1.7 1 0 0 1 1 1 0 rRNA processing DUF87 PF01935.17 EFO63488.1 - 3.2 7.8 9.9 4.4 7.3 0.2 3.8 4 0 0 4 4 4 0 Helicase HerA, central domain RtcB PF01139.17 EFO63489.1 - 2.2e-57 195.1 0.0 9.4e-30 104.1 0.0 2.7 2 1 0 2 2 2 2 tRNA-splicing ligase RtcB VSP PF03302.13 EFO63490.1 - 4.4e-91 305.7 161.8 2.3e-48 165.0 31.3 4.7 1 1 4 5 5 5 5 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO63490.1 - 9.3 6.3 7.3 2 8.5 0.0 2.9 2 1 0 3 3 3 0 Podoplanin PseudoU_synth_1 PF01416.20 EFO63491.1 - 1.5e-21 76.9 0.0 2.9e-17 63.1 0.0 2.5 2 0 0 2 2 2 2 tRNA pseudouridine synthase Ank_2 PF12796.7 EFO63492.1 - 2.3e-69 230.0 31.4 1.8e-11 44.5 0.2 10.9 4 2 7 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63492.1 - 5.9e-32 109.6 20.7 3.1e-06 27.6 0.0 11.5 12 0 0 12 12 12 8 Ankyrin repeats (many copies) Ank PF00023.30 EFO63492.1 - 1.2e-31 107.7 22.5 0.0013 19.1 0.0 13.9 14 1 0 14 14 14 9 Ankyrin repeat Ank_3 PF13606.6 EFO63492.1 - 4.4e-27 91.2 24.6 0.099 13.2 0.0 17.2 19 0 0 19 19 19 8 Ankyrin repeat Ank_5 PF13857.6 EFO63492.1 - 6.1e-27 93.3 35.9 0.013 15.8 0.1 15.5 10 5 8 18 18 18 10 Ankyrin repeats (many copies) MRP-L47 PF06984.13 EFO63492.1 - 0.096 12.8 0.1 0.24 11.5 0.1 1.7 1 0 0 1 1 1 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) NAD_binding_5 PF07994.12 EFO63493.1 - 1.3e-102 343.5 0.0 1.6e-102 343.2 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 EFO63493.1 - 5e-41 139.4 0.2 8.1e-41 138.7 0.2 1.4 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase NMD3 PF04981.13 EFO63494.1 - 1.6e-62 211.1 2.8 2.2e-62 210.7 2.8 1.2 1 0 0 1 1 1 1 NMD3 family ENT PF03735.14 EFO63495.1 - 0.0098 15.9 0.3 0.053 13.6 0.0 2.1 2 0 0 2 2 2 1 ENT domain DUF5617 PF18493.1 EFO63499.1 - 0.026 14.6 0.1 4.1 7.6 0.0 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5617) Chlor_dismutase PF06778.12 EFO63500.1 - 0.031 13.9 0.1 0.039 13.5 0.1 1.2 1 0 0 1 1 1 0 Chlorite dismutase PTE PF02126.18 EFO63500.1 - 0.033 13.6 0.0 0.038 13.4 0.0 1.1 1 0 0 1 1 1 0 Phosphotriesterase family HK_sensor PF16750.5 EFO63500.1 - 0.081 13.2 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 Sensor domain of 2-component histidine kinase Sec2p PF06428.11 EFO63500.1 - 0.18 11.8 4.4 0.42 10.6 0.5 2.0 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p DUF454 PF04304.13 EFO63501.1 - 0.06 13.4 2.0 6.1 6.9 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF454) Mpv17_PMP22 PF04117.12 EFO63501.1 - 0.094 13.0 2.2 0.56 10.5 0.3 2.5 2 1 0 2 2 2 0 Mpv17 / PMP22 family Pkr1 PF08636.10 EFO63501.1 - 0.61 10.3 5.2 0.12 12.5 1.0 1.9 2 0 0 2 2 2 0 ER protein Pkr1 Ank_2 PF12796.7 EFO63502.1 - 4.2e-60 200.3 21.5 4.9e-14 52.7 0.1 6.1 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO63502.1 - 6.8e-41 133.6 12.0 0.017 15.6 0.1 11.1 11 0 0 11 11 11 10 Ankyrin repeat Ank_5 PF13857.6 EFO63502.1 - 5.3e-40 135.0 18.6 2.5e-05 24.5 0.7 10.1 1 1 9 10 10 10 10 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63502.1 - 1e-36 124.8 10.7 5.9e-07 29.9 0.1 9.0 6 3 3 9 9 9 8 Ankyrin repeats (many copies) Ank PF00023.30 EFO63502.1 - 5.8e-34 115.1 9.3 0.0066 16.9 0.0 11.0 11 0 0 11 11 11 9 Ankyrin repeat DUF5401 PF17380.2 EFO63503.1 - 0.029 12.4 3.3 0.061 11.4 3.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5401) MRP-S32 PF10210.9 EFO63503.1 - 0.072 13.6 0.3 0.26 11.9 0.3 1.9 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S32 Spo12 PF05032.12 EFO63503.1 - 0.16 11.9 1.7 0.45 10.5 1.7 1.7 1 0 0 1 1 1 0 Spo12 family Ank_2 PF12796.7 EFO63505.1 - 1.4e-75 249.9 19.4 5.6e-11 42.9 1.6 10.8 2 2 8 11 11 11 11 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO63505.1 - 1.5e-40 132.5 22.1 0.0061 17.0 0.0 18.1 18 0 0 18 18 18 11 Ankyrin repeat Ank PF00023.30 EFO63505.1 - 2.6e-39 132.0 26.0 0.00018 21.8 0.1 17.0 18 1 0 18 18 18 8 Ankyrin repeat Ank_5 PF13857.6 EFO63505.1 - 3.3e-37 126.1 26.9 7.9e-07 29.2 0.2 13.6 10 3 4 14 14 14 8 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63505.1 - 7.1e-35 118.9 15.6 1.3e-05 25.6 0.3 13.2 9 4 4 14 14 14 10 Ankyrin repeats (many copies) Hydrolase_6 PF13344.6 EFO63506.1 - 4.9e-20 71.5 0.0 1e-19 70.5 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFO63506.1 - 3.5e-15 55.8 0.0 6.6e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EFO63506.1 - 0.00039 20.8 0.0 0.92 9.8 0.0 2.5 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EFO63506.1 - 0.0054 16.8 0.0 0.38 10.8 0.0 2.5 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase FleQ PF06490.11 EFO63506.1 - 0.069 13.5 0.0 0.53 10.7 0.0 2.2 2 0 0 2 2 2 0 Flagellar regulatory protein FleQ VSP PF03302.13 EFO63507.1 - 3.5e-61 207.2 129.1 6.2e-41 140.6 22.0 4.2 1 1 3 4 4 4 4 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO63507.1 - 0.0035 17.5 9.7 0.0035 17.5 9.7 7.2 2 2 5 7 7 7 2 Furin-like repeat, cysteine-rich NLE PF08154.12 EFO63508.1 - 4.4e-15 55.9 0.0 1.5e-14 54.2 0.0 2.0 1 0 0 1 1 1 1 NLE (NUC135) domain WD40 PF00400.32 EFO63508.1 - 1.5e-10 41.4 1.1 0.029 15.3 0.5 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat Hydrolase_4 PF12146.8 EFO63509.1 - 1.2e-08 34.5 0.0 0.00043 19.6 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFO63509.1 - 2.7e-08 34.7 0.0 5.3e-08 33.7 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFO63509.1 - 0.00016 21.4 0.1 0.23 11.0 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold LIDHydrolase PF10230.9 EFO63509.1 - 0.0012 18.5 0.0 0.62 9.6 0.0 2.1 1 1 1 2 2 2 2 Lipid-droplet associated hydrolase Peptidase_S9 PF00326.21 EFO63509.1 - 0.0028 17.1 0.0 0.0046 16.4 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Palm_thioest PF02089.15 EFO63509.1 - 0.016 15.0 0.0 0.38 10.6 0.0 2.1 2 0 0 2 2 2 0 Palmitoyl protein thioesterase DUF2974 PF11187.8 EFO63509.1 - 0.038 13.5 0.0 0.088 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_2 PF02230.16 EFO63509.1 - 0.049 13.4 0.2 4.3 7.1 0.0 2.5 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase FSH1 PF03959.13 EFO63509.1 - 0.16 11.6 0.0 0.38 10.4 0.0 1.4 1 1 0 1 1 1 0 Serine hydrolase (FSH1) LSM PF01423.22 EFO63510.1 - 7.2e-16 57.6 0.1 9.2e-16 57.3 0.1 1.1 1 0 0 1 1 1 1 LSM domain CYTH PF01928.21 EFO63511.1 - 2.4e-15 56.9 0.2 2.9e-15 56.6 0.2 1.1 1 0 0 1 1 1 1 CYTH domain Met_10 PF02475.16 EFO63512.1 - 4e-39 134.4 0.0 5.8e-39 133.9 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 EFO63512.1 - 1.4e-05 24.7 0.0 2.4e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EFO63512.1 - 4.8e-05 24.0 0.0 0.00012 22.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain TRM PF02005.16 EFO63512.1 - 0.00017 20.9 0.0 0.00032 20.0 0.0 1.4 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_5 PF01795.19 EFO63512.1 - 0.00034 20.2 0.1 0.00074 19.1 0.0 1.5 2 0 0 2 2 2 1 MraW methylase family Methyltransf_15 PF09445.10 EFO63512.1 - 0.00062 19.4 0.0 0.0013 18.3 0.0 1.5 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 EFO63512.1 - 0.0041 16.5 0.0 0.0069 15.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 EFO63512.1 - 0.016 15.1 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain LRR_6 PF13516.6 EFO63513.1 - 1.3e-26 90.3 32.5 0.0017 18.2 0.2 11.8 11 0 0 11 11 11 9 Leucine Rich repeat LRR_4 PF12799.7 EFO63513.1 - 1.4e-07 31.7 11.8 0.11 13.0 0.1 6.8 5 2 2 7 7 7 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFO63513.1 - 0.00011 22.2 11.1 20 6.2 0.0 8.8 9 0 0 9 9 9 1 Leucine Rich Repeat LRR_8 PF13855.6 EFO63513.1 - 0.039 13.7 18.9 0.046 13.5 0.5 6.5 5 3 0 5 5 5 0 Leucine rich repeat SBP_bac_3 PF00497.20 EFO63513.1 - 0.2 11.1 2.6 0.38 10.2 2.6 1.4 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 TEX12 PF15219.6 EFO63513.1 - 2.2 8.7 5.7 3.2 8.1 0.1 3.3 3 1 1 4 4 4 0 Testis-expressed 12 TPR_MLP1_2 PF07926.12 EFO63513.1 - 4.8 7.3 25.0 0.22 11.6 4.9 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein RRM_1 PF00076.22 EFO63514.1 - 0.00036 20.3 0.0 0.00065 19.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ank_2 PF12796.7 EFO63515.1 - 2.3e-70 233.2 12.3 1.9e-13 50.8 0.1 6.5 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.30 EFO63515.1 - 6.8e-42 140.1 12.7 0.00033 21.0 0.0 12.0 12 0 0 12 12 12 10 Ankyrin repeat Ank_3 PF13606.6 EFO63515.1 - 5e-37 121.7 9.6 0.007 16.8 0.0 12.4 12 0 0 12 12 12 8 Ankyrin repeat Ank_4 PF13637.6 EFO63515.1 - 9.3e-36 121.8 13.0 3e-06 27.7 0.0 9.8 4 3 9 13 13 13 11 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO63515.1 - 4.7e-34 116.0 18.4 3.8e-06 27.1 0.0 10.4 3 2 9 12 12 12 9 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFO63516.1 - 9.5e-60 199.2 17.0 2.7e-13 50.3 0.1 6.3 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63516.1 - 1.4e-26 92.1 14.7 2.6e-05 24.4 0.0 9.2 4 3 6 10 10 10 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63516.1 - 5e-26 90.7 9.7 1.3e-05 25.7 0.1 7.7 5 2 4 9 9 9 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO63516.1 - 1.3e-25 88.6 12.8 0.016 15.7 0.1 9.8 9 1 0 9 9 9 7 Ankyrin repeat Ank_3 PF13606.6 EFO63516.1 - 2.7e-25 85.7 4.9 0.044 14.3 0.0 9.4 9 0 0 9 9 9 7 Ankyrin repeat FAD_binding_1 PF00667.20 EFO63517.1 - 1.7e-16 60.5 0.0 2.9e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EFO63517.1 - 1.8e-13 50.9 0.0 3.2e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 EFO63517.1 - 0.0053 17.0 0.0 0.0087 16.3 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin domain Flavodoxin_3 PF12641.7 EFO63517.1 - 0.15 11.7 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin domain CTP_synth_N PF06418.14 EFO63518.1 - 2.3e-107 358.3 0.1 3.5e-107 357.7 0.1 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EFO63518.1 - 4.8e-46 156.9 0.0 1.4e-45 155.5 0.0 1.8 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EFO63518.1 - 4.1e-08 33.2 0.0 0.0038 17.0 0.0 2.8 3 0 0 3 3 3 2 Peptidase C26 SNO PF01174.19 EFO63518.1 - 4.4e-05 23.4 0.1 0.0018 18.1 0.0 2.4 2 0 0 2 2 2 1 SNO glutamine amidotransferase family DJ-1_PfpI PF01965.24 EFO63518.1 - 0.00012 21.9 0.0 0.00022 21.1 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.14 EFO63518.1 - 0.0012 18.4 0.0 0.0025 17.4 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain CbiA PF01656.23 EFO63518.1 - 0.0046 17.0 0.0 0.0082 16.2 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF3446 PF11928.8 EFO63518.1 - 0.012 15.9 0.9 0.012 15.9 0.9 2.0 2 0 0 2 2 2 0 Early growth response N-terminal domain zf-RanBP PF00641.18 EFO63518.1 - 0.94 8.8 6.0 0.25 10.7 0.6 2.3 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others VSP PF03302.13 EFO63519.1 - 2e-87 293.7 174.7 5.4e-41 140.8 29.1 5.5 1 1 4 5 5 5 5 Giardia variant-specific surface protein zf-C2H2_4 PF13894.6 EFO63520.1 - 9.3e-06 26.1 9.1 0.041 14.7 1.0 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFO63520.1 - 6.1e-05 23.2 1.8 0.0038 17.5 0.9 3.0 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding Zn-C2H2_12 PF18112.1 EFO63520.1 - 0.0013 19.2 4.4 0.23 11.9 0.3 3.3 3 0 0 3 3 3 1 Autophagy receptor zinc finger-C2H2 domain zf-met PF12874.7 EFO63520.1 - 0.0023 18.3 4.3 1.8 9.1 0.9 3.3 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_9 PF16293.5 EFO63520.1 - 0.0073 16.1 5.9 5.6 6.9 0.1 3.4 3 0 0 3 3 3 1 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 EFO63520.1 - 0.01 16.2 7.3 0.31 11.4 1.0 2.8 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 EFO63520.1 - 0.017 14.9 3.0 0.17 11.7 0.9 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2 PF00096.26 EFO63520.1 - 0.041 14.3 12.1 6 7.5 1.2 3.9 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-Di19 PF05605.12 EFO63520.1 - 0.074 13.4 8.9 0.49 10.7 0.3 3.4 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-MYST PF17772.1 EFO63520.1 - 0.085 12.5 0.7 9 6.0 0.0 2.7 3 0 0 3 3 3 0 MYST family zinc finger domain GAGA PF09237.11 EFO63520.1 - 0.39 10.6 8.5 0.24 11.2 0.6 3.3 3 0 0 3 3 3 0 GAGA factor zf_C2H2_6 PF18450.1 EFO63520.1 - 0.41 10.4 4.6 1.2 8.9 0.3 2.4 2 0 0 2 2 2 0 Zinc Finger domain zinc_ribbon_9 PF14369.6 EFO63520.1 - 1.1 9.5 7.0 11 6.4 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon DUF3039 PF11238.8 EFO63520.1 - 2.4 8.0 5.6 23 4.8 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3039) DUF2256 PF10013.9 EFO63520.1 - 4.5 7.5 8.2 11 6.3 0.3 3.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-H2C2_2 PF13465.6 EFO63520.1 - 5.7 7.6 12.7 21 5.8 4.8 3.9 3 1 0 3 3 3 0 Zinc-finger double domain ATP_bind_3 PF01171.20 EFO63522.1 - 1.7e-06 27.9 0.0 2.3e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 PP-loop family Phosphodiest PF01663.22 EFO63525.1 - 5.5e-06 26.2 1.6 6.4e-05 22.7 0.1 2.1 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EFO63525.1 - 0.0002 20.8 0.9 0.0023 17.4 0.9 2.0 1 1 0 1 1 1 1 Sulfatase DUF229 PF02995.17 EFO63525.1 - 0.0029 16.3 0.1 0.0038 15.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) SSTK-IP PF15836.5 EFO63526.1 - 0.038 14.1 0.1 0.091 12.9 0.0 1.6 2 0 0 2 2 2 0 SSTK-interacting protein, TSSK6-activating co-chaperone protein DHHC PF01529.20 EFO63527.1 - 4.3e-28 98.1 5.8 4.3e-28 98.1 5.8 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase Methyltransf_31 PF13847.6 EFO63528.1 - 2.9e-12 46.6 0.0 4.7e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFO63528.1 - 3.9e-11 43.6 0.0 7.8e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFO63528.1 - 1.2e-08 35.6 0.0 3.2e-08 34.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFO63528.1 - 2.5e-07 30.7 0.0 4e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFO63528.1 - 6.6e-07 29.9 0.0 2.2e-06 28.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFO63528.1 - 1.6e-05 24.5 0.0 5.1e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EFO63528.1 - 0.00072 19.6 0.0 0.0017 18.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 EFO63528.1 - 0.0023 17.6 0.0 0.05 13.2 0.0 2.6 2 1 0 2 2 2 1 Nodulation protein S (NodS) Ubie_methyltran PF01209.18 EFO63528.1 - 0.043 13.1 0.0 0.065 12.6 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MetW PF07021.12 EFO63528.1 - 0.045 13.3 0.0 0.18 11.3 0.0 1.9 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW zf-Di19 PF05605.12 EFO63528.1 - 1.2 9.5 6.1 3 8.2 4.6 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Ank_2 PF12796.7 EFO63529.1 - 4e-69 229.2 21.7 4.3e-13 49.7 0.6 7.4 4 2 6 10 10 10 8 Ankyrin repeats (3 copies) Ank PF00023.30 EFO63529.1 - 2.1e-34 116.5 6.2 0.00021 21.6 0.0 10.7 10 0 0 10 10 10 9 Ankyrin repeat Ank_3 PF13606.6 EFO63529.1 - 1.1e-30 102.2 7.5 0.015 15.8 0.0 12.0 11 0 0 11 11 11 8 Ankyrin repeat Ank_5 PF13857.6 EFO63529.1 - 2.3e-29 101.1 21.2 0.00079 19.7 0.0 11.5 5 3 5 11 11 11 9 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63529.1 - 4.1e-29 100.6 9.7 1.6e-06 28.6 0.1 8.8 5 3 4 9 9 9 7 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO63529.1 - 2e-21 76.5 0.1 3.6e-21 75.7 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63529.1 - 7.1e-17 61.5 0.0 1.2e-16 60.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO63529.1 - 0.0049 16.2 0.0 0.013 14.8 0.0 1.7 2 0 0 2 2 2 1 Kinase-like pRN1_helical PF13010.6 EFO63530.1 - 0.0051 16.8 0.4 0.0072 16.3 0.4 1.2 1 0 0 1 1 1 1 Primase helical domain DUF2193 PF09959.9 EFO63530.1 - 0.027 12.9 0.1 0.031 12.7 0.1 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2193) KASH_CCD PF14662.6 EFO63530.1 - 0.05 13.4 7.6 0.045 13.6 4.2 1.9 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH FAM184 PF15665.5 EFO63530.1 - 0.06 13.1 4.9 0.071 12.9 4.9 1.1 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B TMPIT PF07851.13 EFO63530.1 - 0.08 12.2 0.9 0.092 12.0 0.9 1.1 1 0 0 1 1 1 0 TMPIT-like protein HLH PF00010.26 EFO63531.1 - 8.8e-05 22.4 1.6 0.15 12.1 0.2 2.8 2 1 0 2 2 2 2 Helix-loop-helix DNA-binding domain Sds3 PF08598.11 EFO63531.1 - 0.00015 21.9 6.5 0.00015 21.9 6.5 1.9 1 1 1 2 2 2 1 Sds3-like PepX_N PF09168.10 EFO63531.1 - 0.0021 18.5 0.7 0.0043 17.5 0.7 1.7 1 1 0 1 1 1 1 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal TLE_N PF03920.15 EFO63531.1 - 0.032 14.3 1.7 0.032 14.3 1.7 2.2 2 1 1 3 3 3 0 Groucho/TLE N-terminal Q-rich domain TraF_2 PF13729.6 EFO63531.1 - 0.33 10.3 2.4 0.81 9.0 2.5 1.6 1 1 0 1 1 1 0 F plasmid transfer operon, TraF, protein DUF16 PF01519.16 EFO63531.1 - 0.48 10.9 5.4 0.34 11.4 0.4 2.4 2 1 0 2 2 2 0 Protein of unknown function DUF16 DUF2203 PF09969.9 EFO63531.1 - 2.9 8.6 6.3 1.7 9.3 1.1 2.3 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) Ribosomal_L14e PF01929.17 EFO63532.1 - 1.1e-10 41.8 2.2 1.5e-10 41.4 2.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 EFO63532.1 - 0.092 12.7 0.0 0.2 11.7 0.0 1.7 1 0 0 1 1 1 0 KOW motif Phage_holin_4_1 PF05105.12 EFO63533.1 - 0.015 15.4 0.4 0.024 14.8 0.3 1.4 1 1 0 1 1 1 0 Bacteriophage holin family Ribosomal_S10 PF00338.22 EFO63534.1 - 1.1e-14 54.4 0.0 1.4e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e FAM150 PF15129.6 EFO63534.1 - 0.066 13.4 0.0 0.084 13.0 0.0 1.1 1 0 0 1 1 1 0 FAM150 family Ank_2 PF12796.7 EFO63535.1 - 7.9e-44 148.1 11.4 1.2e-10 41.8 0.6 6.2 3 3 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63535.1 - 2.9e-28 97.9 6.8 9.9e-05 22.8 0.0 7.8 6 1 1 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO63535.1 - 4.5e-25 87.4 12.1 0.0025 18.1 0.0 8.4 5 1 3 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63535.1 - 3.3e-21 73.1 10.0 0.1 13.2 0.0 10.0 10 0 0 10 10 10 6 Ankyrin repeat Ank PF00023.30 EFO63535.1 - 1.6e-18 66.2 11.5 0.0074 16.7 0.1 9.5 8 1 1 9 9 9 5 Ankyrin repeat DivIC PF04977.15 EFO63535.1 - 0.022 14.5 14.9 0.41 10.5 1.4 3.5 3 0 0 3 3 3 0 Septum formation initiator bZIP_1 PF00170.21 EFO63535.1 - 0.95 9.6 6.9 9.2 6.4 0.4 3.3 2 1 0 2 2 2 0 bZIP transcription factor TMF_DNA_bd PF12329.8 EFO63535.1 - 1.1 9.3 18.5 0.16 12.0 2.1 3.8 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding SlyX PF04102.12 EFO63535.1 - 2.9 8.6 22.0 1 10.0 3.9 3.7 2 1 2 4 4 4 0 SlyX NYD-SP28_assoc PF14775.6 EFO63535.1 - 6.5 7.0 5.4 41 4.4 1.0 3.3 3 0 0 3 3 3 0 Sperm tail C-terminal domain ZapB PF06005.12 EFO63535.1 - 9.5 6.7 21.4 7.3 7.1 1.9 3.8 2 1 1 3 3 3 0 Cell division protein ZapB USP8_interact PF08941.10 EFO63535.1 - 9.9 5.9 10.8 0.4 10.5 0.9 2.7 2 1 0 2 2 2 0 USP8 interacting zf-C2HC5 PF06221.13 EFO63536.1 - 5.5e-15 55.1 7.7 9.4e-15 54.4 7.7 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type WD40 PF00400.32 EFO63537.1 - 7.4e-06 26.6 1.1 0.34 11.9 0.0 4.8 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO63537.1 - 0.0035 17.6 0.0 0.53 10.6 0.0 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ank_2 PF12796.7 EFO63538.1 - 1.1e-22 80.4 0.0 2.7e-10 40.7 0.0 3.8 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO63538.1 - 6.2e-11 41.5 0.8 0.055 14.0 0.0 5.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EFO63538.1 - 7.4e-10 39.2 0.6 0.48 11.1 0.0 4.9 4 0 0 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO63538.1 - 1.5e-09 37.9 0.0 0.023 15.0 0.0 4.5 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO63538.1 - 1.6e-08 34.6 0.2 0.02 15.3 0.0 5.0 4 0 0 4 4 4 3 Ankyrin repeat MatE PF01554.18 EFO63540.1 - 0.0017 18.0 37.2 0.0045 16.6 14.1 3.3 2 1 1 3 3 3 2 MatE Pro_3_hydrox_C PF05373.11 EFO63542.1 - 0.14 12.2 0.0 0.4 10.8 0.0 1.7 2 0 0 2 2 2 0 L-proline 3-hydroxylase, C-terminal POP1 PF06978.11 EFO63547.1 - 1.3e-07 31.9 7.3 0.00051 20.1 5.2 2.3 1 1 1 2 2 2 2 Ribonucleases P/MRP protein subunit POP1 Ank_2 PF12796.7 EFO63548.1 - 1e-30 106.2 5.1 2.1e-08 34.6 0.8 5.8 3 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63548.1 - 2.8e-19 69.2 1.2 0.046 14.3 0.0 7.3 5 1 2 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO63548.1 - 6.6e-19 67.7 6.0 0.00051 20.3 0.0 6.8 5 2 3 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63548.1 - 3.8e-12 45.3 3.5 0.089 13.4 0.0 8.2 7 1 1 8 8 8 2 Ankyrin repeat Ank PF00023.30 EFO63548.1 - 2.7e-08 33.9 1.0 4.1 8.0 0.0 7.8 7 0 0 7 7 7 1 Ankyrin repeat PPC PF04151.15 EFO63548.1 - 0.05 14.7 0.3 1.7 9.8 0.0 3.3 3 0 0 3 3 3 0 Bacterial pre-peptidase C-terminal domain IQ PF00612.27 EFO63549.1 - 0.0025 17.5 0.4 0.0025 17.5 0.4 3.5 3 0 0 3 3 3 1 IQ calmodulin-binding motif ATP-grasp_5 PF13549.6 EFO63550.1 - 4.3e-63 212.7 0.0 7.1e-63 212.0 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 EFO63550.1 - 3.1e-27 95.0 0.3 8.2e-18 64.5 0.0 2.5 2 0 0 2 2 2 2 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EFO63550.1 - 5e-09 36.7 0.0 1.2e-08 35.5 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain CoA_binding PF02629.19 EFO63550.1 - 0.00014 22.4 0.1 0.0015 19.2 0.0 2.7 2 0 0 2 2 2 1 CoA binding domain ATP-grasp_2 PF08442.10 EFO63550.1 - 0.0025 17.4 0.0 0.0057 16.2 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain MutL_C PF08676.11 EFO63551.1 - 1.5e-16 60.5 0.0 3.3e-15 56.1 0.0 2.4 1 1 0 1 1 1 1 MutL C terminal dimerisation domain HATPase_c PF02518.26 EFO63551.1 - 9.8e-05 22.8 0.0 0.00021 21.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EFO63551.1 - 0.00015 21.6 0.0 0.00032 20.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_mis_repair PF01119.19 EFO63551.1 - 0.062 13.0 0.0 0.18 11.5 0.0 1.7 2 0 0 2 2 2 0 DNA mismatch repair protein, C-terminal domain Kinesin PF00225.23 EFO63552.1 - 1.4e-84 283.9 8.1 1.8e-68 230.9 1.5 2.7 3 0 0 3 3 3 2 Kinesin motor domain Microtub_bd PF16796.5 EFO63552.1 - 7.5e-21 74.6 0.7 4.3e-20 72.2 0.0 2.5 2 0 0 2 2 2 1 Microtubule binding DUF737 PF05300.11 EFO63552.1 - 0.0001 22.7 1.2 0.00029 21.3 1.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF737) PilJ PF13675.6 EFO63552.1 - 0.041 13.9 0.1 0.13 12.3 0.1 1.8 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term TMF_DNA_bd PF12329.8 EFO63552.1 - 0.14 12.2 3.9 0.45 10.5 3.9 1.9 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF1664 PF07889.12 EFO63552.1 - 0.91 9.6 3.1 1.9 8.5 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) BST2 PF16716.5 EFO63552.1 - 1 10.0 6.1 1.8 9.2 1.9 3.1 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 KIAA1430 PF13879.6 EFO63553.1 - 1.3e-15 58.0 12.1 1.3e-15 58.0 12.1 2.0 2 0 0 2 2 2 1 KIAA1430 homologue VSP PF03302.13 EFO63556.1 - 1.9e-42 145.5 190.6 9.3e-28 97.2 72.2 6.2 1 1 3 4 4 4 4 Giardia variant-specific surface protein SKG6 PF08693.10 EFO63556.1 - 0.76 9.2 5.7 1.7 8.1 5.7 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Furin-like_2 PF15913.5 EFO63556.1 - 5.9 7.1 119.9 0.057 13.6 9.6 9.8 2 1 6 9 9 9 0 Furin-like repeat, cysteine-rich VSP PF03302.13 EFO63557.1 - 2.1e-30 105.9 173.4 1.1e-08 34.4 35.8 7.5 1 1 5 6 6 6 6 Giardia variant-specific surface protein DUF4690 PF15756.5 EFO63557.1 - 0.00041 20.9 0.4 0.0012 19.4 0.4 1.7 1 0 0 1 1 1 1 Small Novel Rich in Cartilage LapA_dom PF06305.11 EFO63557.1 - 3.2 7.6 3.7 5.4 6.9 3.7 1.2 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Ank_2 PF12796.7 EFO63558.1 - 2.7e-70 233.0 28.0 1.3e-17 64.1 0.3 8.5 3 2 5 9 9 9 7 Ankyrin repeats (3 copies) Ank PF00023.30 EFO63558.1 - 1.2e-41 139.4 11.9 0.00058 20.2 0.0 13.3 10 3 3 13 13 13 9 Ankyrin repeat Ank_5 PF13857.6 EFO63558.1 - 1.4e-31 108.1 19.1 0.0006 20.1 0.1 12.8 5 3 9 14 14 14 10 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63558.1 - 2.5e-31 107.6 19.5 6.1e-05 23.5 0.1 10.4 9 3 3 12 12 12 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63558.1 - 1.4e-30 101.9 14.3 0.12 13.0 0.0 14.2 13 1 1 14 14 14 8 Ankyrin repeat AT_hook PF02178.19 EFO63559.1 - 0.051 13.5 0.8 0.1 12.5 0.8 1.5 1 0 0 1 1 1 0 AT hook motif SHIPPO-rpt PF07004.12 EFO63560.1 - 7.6 7.6 13.7 0.73 10.9 2.3 2.9 3 0 0 3 3 3 0 Sperm-tail PG-rich repeat EGF_2 PF07974.13 EFO63561.1 - 1.5e-06 28.5 49.2 0.00039 20.7 10.7 5.5 4 2 0 4 4 4 3 EGF-like domain EGF PF00008.27 EFO63561.1 - 2.4e-05 24.5 32.9 0.016 15.5 0.5 5.1 4 1 0 4 4 4 3 EGF-like domain Toxin_2 PF00451.19 EFO63561.1 - 0.015 15.6 4.8 0.015 15.6 4.8 3.9 4 0 0 4 4 4 0 Scorpion short toxin, BmKK2 Asp_protease PF09668.10 EFO63562.1 - 2.2e-27 95.3 0.4 8.4e-27 93.4 0.2 2.0 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 EFO63562.1 - 8e-11 42.4 0.1 2.6e-10 40.7 0.0 1.9 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EFO63562.1 - 3.7e-05 24.3 0.0 8.9e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 EFO63562.1 - 0.023 15.0 0.0 0.056 13.8 0.0 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease Ank_2 PF12796.7 EFO63563.1 - 5.5e-56 187.1 7.1 1.2e-16 61.0 0.1 4.8 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63563.1 - 1.5e-36 124.3 0.2 3.3e-08 33.9 0.0 6.2 5 1 1 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO63563.1 - 1.5e-31 108.0 1.8 2.3e-06 27.8 0.0 7.5 2 2 5 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO63563.1 - 1.7e-30 104.1 0.0 0.0029 18.0 0.0 8.4 8 0 0 8 8 8 6 Ankyrin repeat Ank_3 PF13606.6 EFO63563.1 - 3.2e-27 91.6 0.1 0.0016 18.8 0.0 9.3 10 0 0 10 10 9 6 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO63563.1 - 5e-13 48.7 11.1 8.6e-13 47.9 11.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO63563.1 - 7.1e-08 32.2 10.6 1.3e-07 31.4 10.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFO63563.1 - 6.7e-05 23.1 12.7 0.00012 22.3 12.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFO63563.1 - 0.0021 17.9 12.9 0.0042 16.9 12.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_14 PF17978.1 EFO63563.1 - 0.0055 17.1 5.2 0.033 14.6 6.1 1.9 2 0 0 2 2 1 1 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 EFO63563.1 - 0.0082 16.1 11.4 0.016 15.1 11.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Ndc80_HEC PF03801.13 EFO63563.1 - 0.085 12.5 1.5 0.16 11.6 0.5 1.9 2 1 0 2 2 2 0 HEC/Ndc80p family zf-RING_UBOX PF13445.6 EFO63563.1 - 1.1 9.3 10.3 2.7 8.1 10.3 1.7 1 0 0 1 1 1 0 RING-type zinc-finger TPR_1 PF00515.28 EFO63564.1 - 1.9e-06 27.4 5.1 0.025 14.4 0.6 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFO63564.1 - 2.3e-05 24.1 3.5 0.82 9.9 0.3 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFO63564.1 - 0.00045 20.1 1.3 0.41 10.8 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_15 PF13429.6 EFO63564.1 - 0.006 15.8 0.0 0.015 14.5 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat DUF3856 PF12968.7 EFO63564.1 - 0.025 14.7 0.1 0.054 13.6 0.1 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) LIP1 PF15904.5 EFO63564.1 - 0.037 14.4 0.3 0.088 13.2 0.3 1.6 1 0 0 1 1 1 0 LKB1 serine/threonine kinase interacting protein 1 DUF4844 PF16133.5 EFO63564.1 - 0.1 13.1 0.1 4.7 7.8 0.3 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4844) TPR_8 PF13181.6 EFO63564.1 - 0.2 11.9 2.6 24 5.4 0.4 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFO63564.1 - 0.42 10.9 6.2 2.4 8.5 0.9 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat RVT_1 PF00078.27 EFO63565.1 - 1.5e-05 24.6 0.1 0.0068 15.9 0.0 2.5 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Telomerase_RBD PF12009.8 EFO63565.1 - 6.8e-05 23.0 0.7 6.8e-05 23.0 0.7 2.3 2 0 0 2 2 2 1 Telomerase ribonucleoprotein complex - RNA binding domain Kinesin PF00225.23 EFO63566.1 - 6.7e-52 176.5 0.0 1.8e-51 175.0 0.0 1.7 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFO63566.1 - 1.4e-05 25.1 0.0 9.9e-05 22.3 0.0 2.4 2 0 0 2 2 2 1 Microtubule binding Gin PF10764.9 EFO63566.1 - 0.028 14.4 0.3 0.028 14.4 0.3 3.2 3 1 0 3 3 3 0 Inhibitor of sigma-G Gin UPF0114 PF03350.16 EFO63566.1 - 0.084 13.1 0.1 0.19 11.9 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein family, UPF0114 DUF4428 PF14471.6 EFO63566.1 - 0.084 12.8 4.0 0.93 9.5 0.2 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) RNA_pol_Rpb1_5 PF04998.17 EFO63568.1 - 2.2e-76 256.8 1.2 2.7e-76 256.5 0.1 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EFO63568.1 - 7.5e-53 179.2 0.4 1.3e-31 110.0 0.1 3.5 2 1 1 3 3 3 2 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.12 EFO63568.1 - 1.6e-52 178.8 0.5 5.3e-51 173.8 0.5 2.5 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_3 PF04983.18 EFO63568.1 - 9.1e-35 119.9 0.0 2.5e-34 118.5 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EFO63568.1 - 4.7e-29 100.5 0.0 1.9e-28 98.5 0.0 2.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Rhodanese_C PF12368.8 EFO63568.1 - 1.2 9.6 3.4 3.4 8.1 0.1 2.6 2 0 0 2 2 2 0 Rhodanase C-terminal Ank_2 PF12796.7 EFO63569.1 - 3.5e-36 123.6 14.8 9e-13 48.6 0.3 6.4 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63569.1 - 1.5e-19 70.1 15.8 0.0023 18.5 0.2 8.7 6 3 2 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO63569.1 - 4.9e-18 65.0 14.6 0.003 17.9 0.0 8.4 4 2 5 9 9 9 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63569.1 - 1.1e-15 56.1 12.3 1.3 9.9 0.0 10.3 10 0 0 10 10 10 6 Ankyrin repeat Ank PF00023.30 EFO63569.1 - 7.1e-15 54.7 13.4 0.058 13.9 0.1 8.5 9 0 0 9 9 9 6 Ankyrin repeat Ribosomal_S28e PF01200.18 EFO63570.1 - 3.1e-29 100.7 1.5 3.3e-29 100.7 1.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e Ank_2 PF12796.7 EFO63572.1 - 3.7e-78 258.1 19.4 2.8e-16 59.9 0.6 6.6 2 2 8 10 10 10 10 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63572.1 - 5.2e-37 125.4 10.6 9.6e-07 29.0 0.3 9.9 5 2 6 11 11 11 9 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63572.1 - 1.1e-31 108.7 13.1 3.3e-08 33.9 0.3 9.1 6 3 3 9 9 9 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63572.1 - 2.2e-27 92.1 11.7 0.054 14.1 0.0 12.0 11 1 1 12 12 12 9 Ankyrin repeat Ank PF00023.30 EFO63572.1 - 1.5e-24 85.3 10.3 0.0011 19.3 0.1 10.8 11 1 1 12 12 12 6 Ankyrin repeat Uds1 PF15456.6 EFO63573.1 - 0.00026 21.2 5.4 0.00026 21.2 5.4 3.1 2 1 0 2 2 2 1 Up-regulated During Septation Csm1_N PF18504.1 EFO63573.1 - 0.024 15.0 1.9 0.024 15.0 1.9 4.9 5 2 0 5 5 5 0 Csm1 N-terminal domain bZIP_1 PF00170.21 EFO63573.1 - 0.4 10.8 30.9 1.1 9.4 1.3 6.1 6 1 1 7 7 7 0 bZIP transcription factor HALZ PF02183.18 EFO63573.1 - 1.4 9.2 16.2 0.89 9.8 2.3 4.3 3 1 1 4 4 4 0 Homeobox associated leucine zipper DUF5320 PF17253.2 EFO63573.1 - 5.1 8.2 7.4 32 5.7 0.1 3.7 3 0 0 3 3 3 0 Family of unknown function (DUF5320) SOAR PF16533.5 EFO63573.1 - 5.2 7.1 10.0 11 6.0 0.1 3.7 4 0 0 4 4 4 0 STIM1 Orai1-activating region Dpy-30 PF05186.13 EFO63576.1 - 1.3e-15 56.8 0.0 1.3e-15 56.8 0.0 1.4 2 0 0 2 2 2 1 Dpy-30 motif RIIa PF02197.17 EFO63576.1 - 0.028 14.1 0.0 0.028 14.1 0.0 1.6 2 0 0 2 2 2 0 Regulatory subunit of type II PKA R-subunit HSP70 PF00012.20 EFO63577.1 - 1.8e-228 759.6 13.5 2.2e-228 759.3 13.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFO63577.1 - 3.8e-14 52.3 3.8 1.7e-12 46.8 1.7 2.3 2 0 0 2 2 2 2 MreB/Mbl protein DDR PF08841.10 EFO63577.1 - 0.0021 17.1 0.1 0.18 10.8 0.1 2.4 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain FGGY_C PF02782.16 EFO63577.1 - 0.016 14.9 0.0 0.05 13.3 0.0 1.8 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain DUF4635 PF15466.6 EFO63577.1 - 0.026 14.1 0.2 0.055 13.0 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) DUF2508 PF10704.9 EFO63577.1 - 0.032 14.4 2.0 7.6 6.8 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2508) BcrAD_BadFG PF01869.20 EFO63577.1 - 0.047 13.2 1.8 0.71 9.3 0.0 3.1 3 1 1 4 4 4 0 BadF/BadG/BcrA/BcrD ATPase family TINF2_N PF14973.6 EFO63577.1 - 0.14 12.5 0.0 0.4 11.0 0.0 1.8 1 0 0 1 1 1 0 TERF1-interacting nuclear factor 2 N-terminus FtsA PF14450.6 EFO63577.1 - 0.21 12.0 9.4 10 6.6 0.6 4.0 3 2 0 3 3 3 0 Cell division protein FtsA SpoIIAA-like PF11964.8 EFO63577.1 - 0.27 12.3 1.5 3.1 8.9 0.0 3.0 3 1 0 3 3 3 0 SpoIIAA-like CdiI_2 PF18593.1 EFO63577.1 - 0.75 10.5 3.7 9.8 6.9 0.3 3.3 2 1 1 3 3 3 0 CdiI immunity protein FIVAR PF07554.13 EFO63577.1 - 3.4 8.5 6.0 2.1 9.2 2.3 2.7 3 0 0 3 3 2 0 FIVAR domain polyprenyl_synt PF00348.17 EFO63579.1 - 6.6e-48 163.0 0.6 3.9e-47 160.5 0.6 1.9 1 1 0 1 1 1 1 Polyprenyl synthetase Questin_oxidase PF14027.6 EFO63580.1 - 0.098 12.2 0.8 0.19 11.2 0.8 1.4 1 0 0 1 1 1 0 Questin oxidase-like Ank_2 PF12796.7 EFO63581.1 - 7.2e-66 218.8 14.3 1.9e-14 54.0 0.1 8.3 4 3 5 9 9 9 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63581.1 - 7.4e-37 124.9 15.8 0.00012 22.3 0.0 11.7 5 3 7 12 12 12 10 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO63581.1 - 1.8e-35 122.6 0.1 2e-32 112.6 0.1 3.2 2 1 0 2 2 2 2 Protein kinase domain Ank_3 PF13606.6 EFO63581.1 - 3.1e-33 110.1 11.8 0.033 14.7 0.0 14.0 14 0 0 14 14 14 9 Ankyrin repeat Ank PF00023.30 EFO63581.1 - 2.3e-32 110.0 19.9 0.0017 18.7 0.0 12.7 13 1 0 13 13 13 8 Ankyrin repeat Ank_4 PF13637.6 EFO63581.1 - 1.9e-31 108.1 10.1 3.7e-10 40.1 0.0 10.1 9 1 0 9 9 9 5 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO63581.1 - 2.1e-24 86.2 0.0 1.9e-22 79.8 0.0 2.9 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO63581.1 - 0.00043 19.7 0.0 0.0013 18.1 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Ank_2 PF12796.7 EFO63582.1 - 1.3e-40 137.8 14.1 1.3e-16 60.9 0.3 5.0 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EFO63582.1 - 7.7e-22 76.7 10.7 0.00014 22.2 0.1 7.1 6 1 1 7 7 7 5 Ankyrin repeat Ank_4 PF13637.6 EFO63582.1 - 2.6e-19 69.3 9.4 0.0033 18.0 0.0 6.5 6 1 1 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO63582.1 - 3e-19 68.8 13.8 0.00034 20.9 0.1 7.3 2 2 5 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63582.1 - 4.5e-19 66.5 11.0 0.0052 17.2 0.0 8.0 7 1 1 8 8 7 5 Ankyrin repeat BRE1 PF08647.11 EFO63582.1 - 3.3e-05 23.9 4.8 3.3e-05 23.9 4.8 4.6 2 1 2 4 4 4 1 BRE1 E3 ubiquitin ligase KASH_CCD PF14662.6 EFO63582.1 - 0.00065 19.6 42.3 0.004 17.0 17.7 3.0 1 1 2 3 3 3 2 Coiled-coil region of CCDC155 or KASH Atg14 PF10186.9 EFO63582.1 - 0.074 12.1 33.8 0.084 12.0 19.7 2.7 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3322 PF11795.8 EFO63582.1 - 0.12 12.4 3.3 0.43 10.6 2.6 2.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) ERM PF00769.19 EFO63582.1 - 0.23 11.2 36.8 2.5 7.9 14.7 2.8 1 1 1 2 2 2 0 Ezrin/radixin/moesin family bZIP_1 PF00170.21 EFO63582.1 - 0.44 10.7 25.5 2.6 8.2 2.7 5.2 4 1 1 5 5 5 0 bZIP transcription factor HALZ PF02183.18 EFO63582.1 - 0.48 10.7 17.4 5.1 7.4 0.3 5.6 5 0 0 5 5 5 0 Homeobox associated leucine zipper DUF2034 PF10356.9 EFO63582.1 - 0.58 9.6 4.3 0.15 11.5 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2034) IFT20 PF14931.6 EFO63582.1 - 1 9.5 32.2 0.42 10.8 12.8 3.8 1 1 2 3 3 3 0 Intraflagellar transport complex B, subunit 20 Rubredoxin_C PF18267.1 EFO63584.1 - 0.014 15.3 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Rubredoxin NAD+ reductase C-terminal domain PSP PF04046.16 EFO63585.1 - 1.2e-12 47.4 0.5 2.1e-12 46.7 0.5 1.4 1 0 0 1 1 1 1 PSP DUF382 PF04037.13 EFO63585.1 - 0.00026 21.1 0.2 0.0021 18.2 0.0 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF382) Nas2_N PF18265.1 EFO63586.1 - 1.2e-14 53.9 0.1 2.5e-14 52.9 0.1 1.5 1 1 0 1 1 1 1 Nas2 N_terminal domain DUF2674 PF10879.8 EFO63586.1 - 0.17 11.5 0.6 1.7 8.3 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2674) Peptidase_M50 PF02163.22 EFO63587.1 - 0.0042 16.4 1.8 0.0043 16.4 0.5 2.1 2 1 0 2 2 2 1 Peptidase family M50 DUF4064 PF13273.6 EFO63587.1 - 0.092 13.0 0.3 0.092 13.0 0.3 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF4064) DUF202 PF02656.15 EFO63587.1 - 0.41 11.1 7.6 0.41 11.1 3.6 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF202) DUF2568 PF10823.8 EFO63587.1 - 0.54 10.6 3.6 0.33 11.3 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2568) Ion_trans_2 PF07885.16 EFO63588.1 - 2.8e-10 40.0 2.0 2.8e-10 40.0 2.0 2.3 2 0 0 2 2 2 1 Ion channel DUF4201 PF13870.6 EFO63589.1 - 6.3e-20 71.6 12.7 6.3e-20 71.6 12.7 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) Prefoldin_2 PF01920.20 EFO63589.1 - 0.034 14.1 13.3 0.61 10.1 0.7 4.0 4 0 0 4 4 4 0 Prefoldin subunit YscO-like PF16789.5 EFO63589.1 - 2.3 8.2 11.1 1.3 9.0 1.4 2.5 1 1 1 2 2 2 0 YscO-like protein DUF16 PF01519.16 EFO63589.1 - 2.9 8.4 13.2 0.55 10.8 3.3 3.0 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF724 PF05266.14 EFO63589.1 - 3.9 7.3 14.2 4.9 6.9 1.5 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF724) TPR_MLP1_2 PF07926.12 EFO63589.1 - 5.7 7.0 19.5 0.024 14.7 6.4 3.2 4 0 0 4 4 4 0 TPR/MLP1/MLP2-like protein TMPIT PF07851.13 EFO63589.1 - 9.2 5.4 11.4 9.3 5.4 1.6 2.8 1 1 2 3 3 3 0 TMPIT-like protein LisH PF08513.11 EFO63591.1 - 0.00075 19.4 0.1 0.0022 17.9 0.1 1.9 1 0 0 1 1 1 1 LisH LisH_2 PF16045.5 EFO63591.1 - 0.41 9.7 3.3 0.26 10.3 0.1 2.2 2 0 0 2 2 2 0 LisH XPG_N PF00752.17 EFO63593.1 - 9.8e-13 48.5 0.0 2.4e-12 47.2 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EFO63593.1 - 1e-09 38.6 0.0 2.4e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 EFO63593.1 - 0.002 17.7 0.0 0.0041 16.6 0.0 1.6 1 0 0 1 1 1 1 XPG domain containing Propep_M14 PF02244.16 EFO63596.1 - 0.16 12.4 0.0 0.66 10.4 0.0 1.9 2 0 0 2 2 2 0 Carboxypeptidase activation peptide Ank_2 PF12796.7 EFO63597.1 - 9.8e-85 279.2 42.1 4.5e-11 43.2 0.1 12.2 6 4 9 15 15 15 15 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63597.1 - 9.8e-42 140.5 39.1 0.0019 18.5 0.0 16.4 8 5 8 16 16 16 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63597.1 - 1.3e-34 114.3 36.8 0.15 12.7 0.2 20.1 21 0 0 21 21 21 9 Ankyrin repeat Ank_4 PF13637.6 EFO63597.1 - 2.4e-34 117.3 32.6 0.00056 20.4 0.7 15.0 13 3 3 16 16 16 9 Ankyrin repeats (many copies) Ank PF00023.30 EFO63597.1 - 1.7e-28 97.8 39.6 0.37 11.3 0.0 19.7 20 2 0 20 20 20 8 Ankyrin repeat ATG16 PF08614.11 EFO63597.1 - 0.00056 20.2 2.8 0.00056 20.2 2.8 3.4 3 0 0 3 3 3 1 Autophagy protein 16 (ATG16) DUF4201 PF13870.6 EFO63597.1 - 0.13 11.9 16.1 0.032 14.0 4.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Spc7 PF08317.11 EFO63597.1 - 3.1 6.6 13.6 0.048 12.5 5.3 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein CC2-LZ PF16516.5 EFO63598.1 - 0.0015 18.8 1.3 0.0015 18.8 1.3 7.8 8 2 2 10 10 10 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Bacillus_HBL PF05791.11 EFO63598.1 - 0.002 18.0 20.8 0.14 12.0 0.4 6.5 6 1 0 6 6 6 2 Bacillus haemolytic enterotoxin (HBL) DUF5082 PF16888.5 EFO63598.1 - 0.1 12.9 33.0 2.2 8.6 0.4 7.8 7 1 0 7 7 7 0 Domain of unknown function (DUF5082) DUF2316 PF10078.9 EFO63598.1 - 0.11 12.8 1.9 1 9.6 0.1 3.6 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2316) SlyX PF04102.12 EFO63598.1 - 1.4 9.6 48.7 2 9.1 0.4 10.0 11 0 0 11 11 11 0 SlyX VGPC1_C PF16799.5 EFO63598.1 - 6.5 6.8 26.2 13 5.8 0.1 7.5 8 0 0 8 8 8 0 C-terminal membrane-localisation domain of ion-channel, VCN1 XLF PF09302.11 EFO63598.1 - 7.5 6.7 22.9 33 4.6 0.6 7.0 6 1 1 7 7 7 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component Phasin PF05597.11 EFO63598.1 - 8.6 6.4 11.9 4.5 7.3 0.1 5.0 5 0 0 5 5 5 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Histone PF00125.24 EFO63600.1 - 9e-43 145.8 5.5 1e-42 145.6 5.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EFO63600.1 - 8.9e-05 22.8 0.0 0.00023 21.5 0.0 1.7 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 EFO63600.1 - 0.00022 21.8 2.9 0.00024 21.7 2.9 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 EFO63600.1 - 0.00027 21.0 2.2 0.0007 19.7 0.0 2.3 1 1 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 EFO63600.1 - 0.0013 18.6 0.0 0.0025 17.8 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 EFO63600.1 - 0.0043 17.1 0.0 0.0076 16.3 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 EFO63600.1 - 0.039 14.3 3.8 0.062 13.6 0.1 2.6 2 1 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Ank_2 PF12796.7 EFO63601.1 - 4.6e-22 78.4 3.0 4.1e-09 36.9 0.3 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EFO63601.1 - 5.7e-15 55.0 2.0 0.015 15.8 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EFO63601.1 - 6.2e-14 51.9 3.4 0.0014 18.9 0.1 5.1 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63601.1 - 1.9e-12 46.2 3.1 0.19 12.4 0.2 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 EFO63601.1 - 6.4e-08 33.0 4.0 0.47 11.1 0.0 5.0 3 2 1 4 4 4 2 Ankyrin repeats (many copies) Nucleoporin_N PF08801.11 EFO63602.1 - 6.9e-27 94.3 0.3 2.5e-26 92.4 0.3 1.9 1 1 0 1 1 1 1 Nup133 N terminal like ABC_tran PF00005.27 EFO63604.1 - 1.6e-48 164.7 0.0 1.7e-26 93.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFO63604.1 - 7.5e-29 101.2 43.0 5.3e-21 75.5 15.1 2.6 2 1 1 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EFO63604.1 - 1.3e-11 44.4 1.4 0.00046 19.7 0.0 4.3 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EFO63604.1 - 1.1e-05 25.4 0.5 0.23 11.6 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EFO63604.1 - 0.00019 21.1 0.1 0.89 9.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF87 PF01935.17 EFO63604.1 - 0.00028 21.0 1.1 0.089 12.9 0.0 2.6 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_21 PF13304.6 EFO63604.1 - 0.00043 20.2 1.1 14 5.4 0.0 4.4 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EFO63604.1 - 0.0023 18.3 0.2 1.7 9.0 0.0 3.2 3 0 0 3 3 3 1 AAA ATPase domain AAA_23 PF13476.6 EFO63604.1 - 0.0024 18.4 0.2 3.7 8.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain MeaB PF03308.16 EFO63604.1 - 0.0059 15.6 0.2 0.99 8.3 0.0 2.3 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 EFO63604.1 - 0.0096 15.8 0.0 1.4 8.8 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EFO63604.1 - 0.018 15.3 0.2 2.6 8.3 0.0 3.0 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.22 EFO63604.1 - 0.085 12.0 0.2 3.5 6.7 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain ATP-synt_ab PF00006.25 EFO63604.1 - 0.19 11.3 0.0 2.3 7.8 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Dynamin_N PF00350.23 EFO63604.1 - 0.22 11.6 1.1 4.3 7.4 0.1 2.6 3 0 0 3 3 3 0 Dynamin family NACHT PF05729.12 EFO63604.1 - 1.6 8.7 3.4 1.5 8.7 0.0 2.8 4 0 0 4 4 4 0 NACHT domain PHF5 PF03660.14 EFO63605.1 - 0.052 13.7 0.5 0.052 13.7 0.5 1.7 2 0 0 2 2 2 0 PHF5-like protein Zn_ribbon_SprT PF17283.2 EFO63605.1 - 0.74 9.8 0.0 0.74 9.8 0.0 3.0 4 0 0 4 4 4 0 SprT-like zinc ribbon domain zf-UBR PF02207.20 EFO63605.1 - 1.9 8.7 6.8 10 6.4 0.2 2.9 2 1 1 3 3 3 0 Putative zinc finger in N-recognin (UBR box) Ribosomal_L38e PF01781.18 EFO63606.1 - 4.9e-08 33.0 0.4 5.1e-08 32.9 0.4 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family Mt_ATP-synt_D PF05873.12 EFO63607.1 - 0.21 11.4 5.1 4.2 7.2 1.0 3.0 2 1 1 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) MIP-T3_C PF17749.1 EFO63607.1 - 0.93 9.4 25.7 2.7 7.9 1.5 4.0 4 1 0 4 4 4 0 Microtubule-binding protein MIP-T3 C-terminal region Syntaxin-6_N PF09177.11 EFO63607.1 - 1.8 9.2 22.4 1.1 9.8 2.8 4.6 3 2 1 4 4 4 0 Syntaxin 6, N-terminal SpoIISA_toxin PF14171.6 EFO63607.1 - 4.6 6.9 7.9 2 8.0 5.1 1.8 2 0 0 2 2 2 0 Toxin SpoIISA, type II toxin-antitoxin system LUC7 PF03194.15 EFO63607.1 - 4.9 6.7 18.9 6.4 6.4 0.3 3.4 3 1 0 3 3 3 0 LUC7 N_terminus SlyX PF04102.12 EFO63607.1 - 8.4 7.1 23.6 3.1 8.5 0.3 5.3 4 1 0 5 5 5 0 SlyX DUF948 PF06103.11 EFO63607.1 - 8.5 6.7 21.9 9.6 6.5 1.7 5.0 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) zf-CCHC_3 PF13917.6 EFO63608.1 - 0.00031 20.6 16.6 0.016 15.2 0.3 3.9 4 0 0 4 4 4 2 Zinc knuckle zf-CCHC PF00098.23 EFO63608.1 - 0.0034 17.4 11.7 0.0092 16.0 2.7 5.7 6 0 0 6 6 6 4 Zinc knuckle Ribosomal_S21e PF01249.18 EFO63609.1 - 2e-31 107.9 0.0 2.3e-31 107.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e DUF4934 PF16288.5 EFO63610.1 - 0.0083 16.0 0.0 0.026 14.4 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4934) IF4E PF01652.18 EFO63612.1 - 5.5e-13 49.0 0.0 1.2e-12 47.9 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic initiation factor 4E Calponin PF00402.18 EFO63612.1 - 0.045 13.4 0.3 0.084 12.5 0.3 1.4 1 0 0 1 1 1 0 Calponin family repeat RNase_PH PF01138.21 EFO63615.1 - 1.7e-09 38.3 0.1 3.8e-09 37.2 0.1 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EFO63615.1 - 0.11 12.6 0.0 0.26 11.3 0.0 1.7 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 Helicase_C_2 PF13307.6 EFO63616.1 - 1e-48 165.8 0.0 3.7e-48 163.9 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 EFO63616.1 - 4e-32 111.3 1.8 7.4e-32 110.4 1.0 1.9 2 0 0 2 2 2 1 DEAD_2 ResIII PF04851.15 EFO63616.1 - 2e-05 24.7 0.1 0.0033 17.4 0.0 3.5 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFO63616.1 - 4.1e-05 23.4 0.3 0.0002 21.2 0.0 2.3 3 0 0 3 3 3 1 DEAD/DEAH box helicase HBB PF06777.11 EFO63616.1 - 0.001 18.8 0.0 0.0024 17.6 0.0 1.6 1 0 0 1 1 1 1 Helical and beta-bridge domain VSP PF03302.13 EFO63617.1 - 2.4e-159 530.5 204.3 1.7e-148 494.7 112.4 4.5 1 1 3 4 4 4 2 Giardia variant-specific surface protein PK PF00224.21 EFO63618.1 - 2.3e-86 289.8 0.7 3e-86 289.5 0.7 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 EFO63618.1 - 3.8e-23 81.9 0.0 3.2e-22 78.9 0.0 2.3 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 EFO63618.1 - 0.02 14.1 0.1 0.048 12.8 0.1 1.7 1 1 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.25 EFO63618.1 - 0.021 13.9 0.1 0.072 12.1 0.0 1.8 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain DUF3861 PF12977.7 EFO63618.1 - 0.11 12.7 0.0 0.35 11.1 0.0 1.8 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) Lactamase_B_2 PF12706.7 EFO63619.1 - 1.6e-09 37.6 0.0 3.1e-07 30.1 0.0 2.3 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EFO63619.1 - 0.00034 20.7 0.1 0.00056 20.0 0.1 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 EFO63619.1 - 0.013 15.2 0.0 0.027 14.2 0.0 1.5 1 0 0 1 1 1 0 tRNase Z endonuclease Peptidase_M26_N PF05342.14 EFO63620.1 - 0.029 13.8 1.4 0.17 11.3 0.1 2.2 2 0 0 2 2 2 0 M26 IgA1-specific Metallo-endopeptidase N-terminal region DUF3149 PF11346.8 EFO63620.1 - 0.18 11.5 0.7 0.38 10.4 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) UQ_con PF00179.26 EFO63622.1 - 1.4e-42 144.6 0.0 1.7e-42 144.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFO63622.1 - 0.011 16.0 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 0 RWD domain UFC1 PF08694.11 EFO63622.1 - 0.074 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 WD40 PF00400.32 EFO63626.1 - 1.7e-13 50.8 9.2 0.011 16.6 0.0 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat PQQ_3 PF13570.6 EFO63626.1 - 0.23 12.0 1.2 0.47 11.0 0.0 2.1 2 0 0 2 2 2 0 PQQ-like domain ATP_bind_1 PF03029.17 EFO63627.1 - 5e-54 183.6 0.1 1.5e-52 178.8 0.1 2.4 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EFO63627.1 - 4.9e-06 26.6 0.0 7.5e-05 22.8 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EFO63627.1 - 2.3e-05 24.9 0.0 4.5e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.27 EFO63627.1 - 3.5e-05 23.4 0.0 0.1 12.1 0.0 2.6 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFO63627.1 - 5.8e-05 23.1 0.0 0.025 14.5 0.0 3.2 3 0 0 3 3 3 1 RsgA GTPase SRPRB PF09439.10 EFO63627.1 - 6.7e-05 22.4 0.0 0.31 10.4 0.0 2.3 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit AAA_33 PF13671.6 EFO63627.1 - 0.00015 22.0 0.2 0.0004 20.6 0.0 1.9 2 1 0 2 2 1 1 AAA domain AAA_22 PF13401.6 EFO63627.1 - 0.00042 20.6 0.0 0.0013 19.0 0.0 1.8 2 0 0 2 2 1 1 AAA domain FeoB_N PF02421.18 EFO63627.1 - 0.0005 19.6 0.0 0.021 14.4 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B cobW PF02492.19 EFO63627.1 - 0.00089 18.9 0.0 0.051 13.2 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EFO63627.1 - 0.0022 17.9 0.0 0.0044 17.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Ras PF00071.22 EFO63627.1 - 0.0046 16.6 0.0 1.1 8.9 0.0 2.3 2 0 0 2 2 2 1 Ras family G-alpha PF00503.20 EFO63627.1 - 0.0048 16.1 0.1 0.085 12.0 0.0 2.4 2 1 0 2 2 2 1 G-protein alpha subunit AAA_30 PF13604.6 EFO63627.1 - 0.0052 16.5 0.0 0.0095 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EFO63627.1 - 0.0085 16.0 0.0 0.23 11.3 0.0 2.5 2 0 0 2 2 2 1 NTPase SRP54 PF00448.22 EFO63627.1 - 0.01 15.5 0.0 0.033 13.8 0.0 1.9 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain NB-ARC PF00931.22 EFO63627.1 - 0.01 15.0 0.0 0.017 14.3 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain TsaE PF02367.17 EFO63627.1 - 0.011 15.7 0.0 0.023 14.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 EFO63627.1 - 0.012 14.7 0.0 0.019 14.0 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF87 PF01935.17 EFO63627.1 - 0.014 15.5 0.0 0.078 13.1 0.0 2.0 2 0 0 2 2 2 0 Helicase HerA, central domain MobB PF03205.14 EFO63627.1 - 0.018 15.0 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Arf PF00025.21 EFO63627.1 - 0.022 14.2 0.0 0.3 10.5 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family PduV-EutP PF10662.9 EFO63627.1 - 0.028 14.2 0.0 0.25 11.1 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation KAP_NTPase PF07693.14 EFO63627.1 - 0.029 13.6 0.0 0.029 13.6 0.0 1.3 1 1 0 1 1 1 0 KAP family P-loop domain AAA_18 PF13238.6 EFO63627.1 - 0.034 14.7 0.0 0.089 13.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EFO63627.1 - 0.035 13.4 0.0 0.061 12.6 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin GvpD PF07088.11 EFO63627.1 - 0.035 12.7 0.0 0.062 11.9 0.0 1.3 1 0 0 1 1 1 0 GvpD gas vesicle protein Septin PF00735.18 EFO63627.1 - 0.037 13.3 0.0 0.39 9.9 0.0 2.2 1 1 0 1 1 1 0 Septin AAA_19 PF13245.6 EFO63627.1 - 0.038 14.3 0.0 0.075 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EFO63627.1 - 0.042 13.8 0.0 0.11 12.5 0.0 1.8 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 EFO63627.1 - 0.047 14.2 0.0 2.7 8.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 EFO63627.1 - 0.048 13.9 0.0 0.49 10.6 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Herpes_Helicase PF02689.14 EFO63627.1 - 0.048 11.6 0.0 0.23 9.3 0.0 1.8 2 0 0 2 2 2 0 Helicase AAA_24 PF13479.6 EFO63627.1 - 0.06 13.1 0.2 0.19 11.4 0.1 1.9 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EFO63627.1 - 0.066 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region MeaB PF03308.16 EFO63627.1 - 0.074 12.0 0.0 0.26 10.2 0.0 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 EFO63627.1 - 0.089 13.2 0.4 1.1 9.6 0.1 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 EFO63627.1 - 0.12 12.0 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 EFO63627.1 - 0.14 11.9 0.3 0.27 11.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain CLP1_P PF16575.5 EFO63627.1 - 0.15 11.8 0.0 0.47 10.2 0.0 1.9 1 1 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_14 PF13173.6 EFO63627.1 - 0.16 12.0 0.4 1 9.4 0.0 2.3 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 EFO63627.1 - 0.16 12.4 0.0 0.51 10.8 0.0 1.9 2 0 0 2 2 1 0 RNA helicase Rad17 PF03215.15 EFO63627.1 - 0.16 11.9 0.0 0.57 10.1 0.0 1.9 2 0 0 2 2 1 0 Rad17 P-loop domain Snf7 PF03357.21 EFO63628.1 - 9.7e-06 25.3 14.0 1.6e-05 24.6 14.0 1.3 1 0 0 1 1 1 1 Snf7 DUF211 PF02680.14 EFO63628.1 - 0.026 14.7 0.8 0.063 13.4 0.8 1.7 1 0 0 1 1 1 0 Uncharacterized ArCR, COG1888 AKNA PF12443.8 EFO63628.1 - 0.06 14.0 4.1 0.15 12.8 0.4 2.6 2 1 0 2 2 2 0 AT-hook-containing transcription factor PhoU PF01895.19 EFO63628.1 - 0.17 12.3 0.2 0.17 12.3 0.2 2.7 1 1 1 2 2 2 0 PhoU domain YusW PF14039.6 EFO63628.1 - 0.27 11.8 5.6 0.6 10.7 1.9 2.6 1 1 1 2 2 2 0 YusW-like protein DUF948 PF06103.11 EFO63628.1 - 0.39 11.0 5.7 0.4 11.0 1.7 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TPR_MLP1_2 PF07926.12 EFO63628.1 - 0.91 9.6 14.3 1.5 8.9 1.6 2.8 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF5315 PF17242.2 EFO63628.1 - 1.5 8.7 6.7 3.6 7.5 0.4 3.2 2 1 0 2 2 2 0 Disordered region of unknown function (DUF5315) Prominin PF05478.11 EFO63628.1 - 1.8 6.4 10.6 0.11 10.5 3.5 1.7 1 1 1 2 2 2 0 Prominin FDF PF09532.10 EFO63628.1 - 3.1 8.7 10.8 3.4 8.6 1.9 2.6 2 1 0 2 2 2 0 FDF domain DUF1664 PF07889.12 EFO63628.1 - 5.1 7.2 8.1 2.8 8.0 5.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) LMBR1 PF04791.16 EFO63628.1 - 6.7 5.5 6.6 11 4.8 6.6 1.5 1 1 0 1 1 1 0 LMBR1-like membrane protein Pkinase PF00069.25 EFO63629.1 - 1e-28 100.4 0.0 3.9e-17 62.5 0.0 3.6 4 0 0 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63629.1 - 2e-10 40.4 0.1 2.2e-09 37.0 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFO63629.1 - 5.5e-05 22.3 0.0 9.9e-05 21.4 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFO63629.1 - 0.00053 19.4 0.0 0.0014 18.0 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFO63629.1 - 0.0034 17.4 0.1 0.024 14.6 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFO63629.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like HTH_28 PF13518.6 EFO63630.1 - 2.3e-09 37.2 0.2 1.9e-05 24.7 0.0 2.4 2 1 0 2 2 2 2 Helix-turn-helix domain HTH_23 PF13384.6 EFO63630.1 - 2.6e-08 33.4 0.0 0.00026 20.7 0.0 2.4 2 0 0 2 2 2 2 Homeodomain-like domain HTH_29 PF13551.6 EFO63630.1 - 6.6e-06 26.1 0.0 0.021 14.8 0.0 2.3 2 0 0 2 2 2 2 Winged helix-turn helix HTH_32 PF13565.6 EFO63630.1 - 8e-06 26.4 0.0 1.4e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_1 PF01527.20 EFO63630.1 - 1.2e-05 25.5 0.0 4.6e-05 23.7 0.0 1.9 1 1 1 2 2 2 1 Transposase HTH_33 PF13592.6 EFO63630.1 - 0.0011 18.6 0.0 0.0028 17.2 0.0 1.7 2 0 0 2 2 2 1 Winged helix-turn helix Terminase_5 PF06056.12 EFO63630.1 - 0.0036 17.2 0.0 1.5 8.8 0.0 2.3 2 0 0 2 2 2 2 Putative ATPase subunit of terminase (gpP-like) LZ_Tnp_IS481 PF13011.6 EFO63630.1 - 0.0037 17.8 0.0 1.2 9.7 0.0 2.1 2 0 0 2 2 2 1 leucine-zipper of insertion element IS481 HTH_17 PF12728.7 EFO63630.1 - 0.0071 16.5 0.0 0.51 10.6 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_8 PF02954.19 EFO63630.1 - 0.0095 15.7 0.0 0.12 12.2 0.0 2.1 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family HTH_Tnp_IS630 PF01710.16 EFO63630.1 - 0.02 14.9 0.0 0.78 9.8 0.0 2.2 1 1 0 2 2 2 0 Transposase MerR PF00376.23 EFO63630.1 - 0.057 13.2 0.0 0.27 11.1 0.0 1.9 2 0 0 2 2 2 0 MerR family regulatory protein Stork_head PF10264.9 EFO63630.1 - 0.085 13.0 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain DUF4200 PF13863.6 EFO63631.1 - 1.2e-06 29.0 5.5 1.2e-06 29.0 5.5 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) DUF1241 PF06840.11 EFO63631.1 - 0.01 15.5 0.7 0.01 15.5 0.7 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1241) HALZ PF02183.18 EFO63631.1 - 0.049 13.9 4.1 0.16 12.2 1.7 3.0 2 0 0 2 2 2 0 Homeobox associated leucine zipper CTP_transf_3 PF02348.19 EFO63631.1 - 0.068 13.1 1.7 0.17 11.8 1.7 1.6 1 0 0 1 1 1 0 Cytidylyltransferase Syntaxin_2 PF14523.6 EFO63631.1 - 0.099 13.0 0.2 0.099 13.0 0.2 2.5 2 1 0 2 2 2 0 Syntaxin-like protein Ldi PF18566.1 EFO63631.1 - 0.1 12.1 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 Linalool dehydratase/isomerase RNAse_A_bac PF18431.1 EFO63631.1 - 0.11 13.5 2.1 2.6 9.0 0.1 3.0 2 1 1 3 3 3 0 Bacterial CdiA-CT RNAse A domain DUF2205 PF10224.9 EFO63631.1 - 0.16 11.9 4.0 0.27 11.2 1.2 2.5 1 1 1 2 2 2 0 Short coiled-coil protein IFT57 PF10498.9 EFO63631.1 - 0.22 10.4 11.0 1.8 7.5 4.2 2.2 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 UPF0242 PF06785.11 EFO63631.1 - 1.3 9.1 15.4 0.51 10.4 1.9 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF3552 PF12072.8 EFO63631.1 - 2.4 7.5 18.7 0.25 10.8 7.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF3552) UPF0231 PF06062.11 EFO63631.1 - 2.4 8.4 4.9 0.96 9.7 1.3 2.2 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0231) NPV_P10 PF05531.12 EFO63631.1 - 3.1 8.3 5.9 15 6.1 1.7 3.2 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein CLZ PF16526.5 EFO63631.1 - 3.9 7.9 12.4 2.2 8.7 2.6 3.3 3 1 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Syntaxin-6_N PF09177.11 EFO63631.1 - 5.4 7.6 9.4 19 5.9 2.3 2.7 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Jnk-SapK_ap_N PF09744.9 EFO63631.1 - 7.5 6.8 17.7 13 6.0 0.2 2.8 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 PI31_Prot_C PF08577.11 EFO63633.1 - 0.03 15.5 3.5 0.073 14.3 3.5 1.9 1 1 0 1 1 1 0 PI31 proteasome regulator VSP PF03302.13 EFO63634.1 - 2.4e-15 56.3 199.3 0.0002 20.3 10.4 7.8 1 1 8 9 9 9 7 Giardia variant-specific surface protein Thioredoxin PF00085.20 EFO63635.1 - 5.3e-10 39.2 0.1 6.6e-10 38.9 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 EFO63635.1 - 2.9e-07 30.3 0.0 3.7e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EFO63635.1 - 0.00036 20.8 0.1 0.68 10.3 0.0 2.4 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EFO63635.1 - 0.0019 18.6 0.2 0.0041 17.6 0.2 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain HyaE PF07449.11 EFO63635.1 - 0.0047 16.9 0.0 0.0068 16.4 0.0 1.2 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_3 PF13192.6 EFO63635.1 - 0.0071 16.4 0.1 0.012 15.7 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin domain DUF953 PF06110.11 EFO63635.1 - 0.013 15.1 0.1 0.018 14.7 0.1 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Thioredoxin_7 PF13899.6 EFO63635.1 - 0.021 15.0 0.0 0.035 14.3 0.0 1.5 1 1 0 1 1 1 0 Thioredoxin-like AhpC-TSA PF00578.21 EFO63635.1 - 0.048 13.6 0.0 0.056 13.4 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family Herpes_heli_pri PF05774.11 EFO63635.1 - 0.13 12.4 0.0 0.17 12.1 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus helicase-primase complex component VSP PF03302.13 EFO63637.1 - 3.5e-29 101.9 52.2 3.6e-24 85.3 18.7 2.5 1 1 1 2 2 2 2 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO63637.1 - 0.0049 17.0 0.2 0.0092 16.1 0.2 1.4 1 0 0 1 1 1 1 Podoplanin Ank_2 PF12796.7 EFO63638.1 - 6e-31 106.9 0.7 1.8e-11 44.4 0.3 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63638.1 - 2.1e-22 78.9 4.1 4.5e-07 30.0 0.6 5.6 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO63638.1 - 3.3e-19 69.3 0.0 6.1e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ank PF00023.30 EFO63638.1 - 4.7e-17 61.6 0.5 0.0013 19.1 0.0 6.2 5 1 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 EFO63638.1 - 7.7e-17 61.4 0.4 4.6e-06 27.1 0.2 3.8 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63638.1 - 1.4e-14 52.7 1.8 0.0035 17.7 0.0 6.4 6 0 0 6 6 6 3 Ankyrin repeat Pkinase_Tyr PF07714.17 EFO63638.1 - 1.9e-12 47.0 0.0 3.3e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Fumble PF03630.14 EFO63639.1 - 1.2e-67 228.5 0.0 1.4e-67 228.2 0.0 1.0 1 0 0 1 1 1 1 Fumble DoxX_2 PF13564.6 EFO63639.1 - 0.038 14.1 0.0 0.91 9.7 0.0 2.3 2 0 0 2 2 2 0 DoxX-like family ubiquitin PF00240.23 EFO63640.1 - 3.8e-05 23.3 0.0 6.5e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_5 PF18037.1 EFO63640.1 - 0.073 13.4 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain DUF4922 PF16269.5 EFO63640.1 - 0.13 12.0 0.0 0.4 10.4 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4922) LRR_9 PF14580.6 EFO63642.1 - 6.5e-17 61.6 0.1 9.6e-17 61.0 0.1 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EFO63642.1 - 7.5e-12 45.3 5.8 2.2e-06 27.9 0.1 3.3 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO63642.1 - 2e-08 33.9 0.5 2e-06 27.5 0.0 2.7 2 1 0 3 3 3 1 Leucine rich repeat LRR_6 PF13516.6 EFO63642.1 - 0.024 14.7 1.2 4.7 7.5 0.0 3.2 3 0 0 3 3 3 0 Leucine Rich repeat NMT1 PF09084.11 EFO63642.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 NMT1/THI5 like LRR_1 PF00560.33 EFO63642.1 - 0.46 11.2 3.3 12 6.9 0.1 3.5 3 1 1 4 4 4 0 Leucine Rich Repeat Pkinase PF00069.25 EFO63643.1 - 2.3e-46 158.3 0.0 4.1e-25 88.6 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63643.1 - 1.3e-17 64.0 0.0 2.3e-05 23.8 0.0 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase zf-C2H2_jaz PF12171.8 EFO63644.1 - 1.3e-07 31.7 6.3 0.014 15.6 0.9 4.1 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EFO63644.1 - 5.4e-06 26.8 20.9 0.16 12.9 1.0 5.7 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2 PF00096.26 EFO63644.1 - 1.9e-05 24.8 21.2 0.23 12.0 0.7 5.7 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EFO63644.1 - 0.0034 17.7 12.0 1.2 9.5 0.7 4.8 3 2 2 5 5 5 1 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 EFO63644.1 - 0.0045 17.2 7.7 1.8 8.9 0.3 3.7 3 0 0 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_9 PF16293.5 EFO63644.1 - 0.0065 16.3 6.8 0.057 13.3 0.0 3.8 4 0 0 4 4 4 1 C2H2 type zinc-finger (1 copy) zf-H2C2_5 PF13909.6 EFO63644.1 - 0.022 14.5 0.8 0.022 14.5 0.8 3.3 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-met PF12874.7 EFO63644.1 - 0.15 12.5 13.9 0.47 10.9 0.0 4.2 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 EFO63644.1 - 1.1 9.1 8.0 0.69 9.7 0.5 3.0 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-H2C2_2 PF13465.6 EFO63644.1 - 6.4 7.4 19.1 1.9 9.1 0.1 4.6 4 1 0 4 4 4 0 Zinc-finger double domain zf_C2H2_ZHX PF18387.1 EFO63644.1 - 9.5 6.0 12.3 2.8 7.6 0.5 3.2 3 1 1 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain Acetyltransf_1 PF00583.25 EFO63645.1 - 3e-19 69.4 0.0 4.4e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFO63645.1 - 6.6e-11 42.2 0.1 1e-10 41.7 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFO63645.1 - 3.4e-09 37.0 0.0 5.3e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFO63645.1 - 1.5e-06 28.3 0.0 7.1e-06 26.1 0.1 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFO63645.1 - 4.8e-05 23.2 0.0 7.6e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EFO63645.1 - 0.00025 21.1 0.0 0.0005 20.2 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 EFO63645.1 - 0.027 15.2 0.0 0.038 14.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Sep15_SelM PF08806.11 EFO63645.1 - 0.13 12.5 0.0 1.2 9.3 0.0 2.2 2 0 0 2 2 2 0 Sep15/SelM redox domain Acetyltransf_15 PF17013.5 EFO63645.1 - 0.14 11.6 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase eIF-1a PF01176.19 EFO63646.1 - 5.9e-11 42.0 0.0 9.6e-11 41.3 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 RsgA_N PF16745.5 EFO63646.1 - 0.00045 19.9 0.1 0.00094 18.9 0.1 1.5 1 0 0 1 1 1 1 RsgA N-terminal domain OpcA PF07239.11 EFO63646.1 - 0.093 12.4 0.9 0.17 11.6 0.9 1.3 1 0 0 1 1 1 0 Outer membrane protein OpcA Thermopsin PF05317.11 EFO63647.1 - 0.27 10.6 0.0 0.4 10.1 0.0 1.2 1 0 0 1 1 1 0 Thermopsin DHHC PF01529.20 EFO63648.1 - 1e-17 64.5 2.9 2.5e-17 63.2 2.9 1.7 1 0 0 1 1 1 1 DHHC palmitoyltransferase RNase_T PF00929.24 EFO63649.1 - 3.5e-06 27.6 0.0 1.1e-05 26.0 0.0 1.8 1 1 0 1 1 1 1 Exonuclease PAXNEB PF05625.11 EFO63649.1 - 0.14 11.3 1.5 0.33 10.0 1.5 1.7 1 1 0 1 1 1 0 PAXNEB protein Lipase_3 PF01764.25 EFO63650.1 - 1.6e-17 63.7 0.0 7.4e-16 58.3 0.0 2.4 2 0 0 2 2 2 1 Lipase (class 3) Hydrolase_4 PF12146.8 EFO63650.1 - 0.072 12.3 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Ank_2 PF12796.7 EFO63651.1 - 1.8e-39 134.2 5.1 1.3e-09 38.5 0.1 4.2 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63651.1 - 9.2e-26 89.6 7.5 3.9e-07 30.2 0.0 7.0 3 2 4 7 7 7 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63651.1 - 1.1e-25 89.6 2.8 5e-05 23.8 0.0 7.7 7 1 1 8 8 8 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO63651.1 - 6.8e-24 83.2 7.4 0.00045 20.5 0.0 8.7 8 2 1 9 9 9 5 Ankyrin repeat Ank_3 PF13606.6 EFO63651.1 - 1.3e-18 65.2 9.9 0.044 14.3 0.0 8.8 9 0 0 9 9 9 5 Ankyrin repeat SurE PF01975.17 EFO63653.1 - 2e-40 138.7 0.0 2.6e-40 138.3 0.0 1.1 1 0 0 1 1 1 1 Survival protein SurE YscW PF09619.10 EFO63653.1 - 0.00093 19.5 0.0 0.0017 18.6 0.0 1.4 1 0 0 1 1 1 1 Type III secretion system lipoprotein chaperone (YscW) DUF948 PF06103.11 EFO63654.1 - 0.0053 17.0 1.7 0.0058 16.9 1.7 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) BLOC1_2 PF10046.9 EFO63654.1 - 0.0097 16.2 1.6 0.037 14.3 0.9 1.5 1 1 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cytochrom_B562 PF07361.11 EFO63654.1 - 0.037 14.7 0.2 0.039 14.6 0.2 1.1 1 0 0 1 1 1 0 Cytochrome b562 DUF16 PF01519.16 EFO63654.1 - 0.039 14.4 0.6 0.039 14.4 0.6 1.0 1 0 0 1 1 1 0 Protein of unknown function DUF16 DUF2461 PF09365.10 EFO63654.1 - 0.051 13.5 0.1 0.056 13.4 0.1 1.0 1 0 0 1 1 1 0 Conserved hypothetical protein (DUF2461) ABC_tran PF00005.27 EFO63655.1 - 1.7e-47 161.4 0.0 1.9e-24 86.7 0.0 2.3 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EFO63655.1 - 3e-10 40.4 0.0 0.02 14.7 0.0 3.5 3 0 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFO63655.1 - 5.1e-06 26.1 1.6 0.00011 21.9 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain SMC_N PF02463.19 EFO63655.1 - 0.0017 17.8 0.0 0.39 10.1 0.0 3.0 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFO63655.1 - 0.0045 17.5 0.2 0.0097 16.4 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFO63655.1 - 0.0065 16.2 0.9 1.2 8.8 0.1 2.7 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EFO63655.1 - 0.025 14.5 1.3 1.3 8.9 0.0 2.8 3 0 0 3 3 3 0 RsgA GTPase MukB PF04310.12 EFO63655.1 - 0.029 14.2 0.1 0.029 14.2 0.1 1.7 2 0 0 2 2 2 0 MukB N-terminal AAA_16 PF13191.6 EFO63655.1 - 0.087 13.2 1.1 4 7.8 0.0 3.0 3 1 0 3 3 3 0 AAA ATPase domain AAA_25 PF13481.6 EFO63655.1 - 0.14 11.7 2.5 17 5.0 0.0 2.6 2 1 0 2 2 2 0 AAA domain FYRN PF05964.14 EFO63655.1 - 0.17 11.7 0.1 0.45 10.4 0.1 1.6 1 0 0 1 1 1 0 F/Y-rich N-terminus AAA_27 PF13514.6 EFO63655.1 - 0.2 11.2 0.1 0.47 10.0 0.1 1.6 1 0 0 1 1 1 0 AAA domain zf-rbx1 PF12678.7 EFO63656.1 - 3.4e-18 65.7 13.2 4.8e-18 65.2 13.2 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EFO63656.1 - 1.2e-15 57.4 8.1 1.3e-15 57.2 8.1 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EFO63656.1 - 5.8e-08 32.9 17.1 1e-06 29.0 17.1 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFO63656.1 - 1.5e-06 27.9 10.3 1.5e-06 27.9 10.3 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFO63656.1 - 7.6e-06 25.7 13.1 3.9e-05 23.4 13.1 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFO63656.1 - 0.00052 20.0 11.2 0.0014 18.6 9.7 2.2 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFO63656.1 - 0.031 14.3 14.9 1.8 8.6 15.5 2.4 1 1 1 2 2 2 0 zinc-RING finger domain DZR PF12773.7 EFO63656.1 - 0.039 14.0 12.3 0.25 11.4 5.0 2.3 1 1 1 2 2 2 0 Double zinc ribbon zf-C3HC4_3 PF13920.6 EFO63656.1 - 0.042 13.7 15.1 0.11 12.4 8.9 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFO63656.1 - 0.36 11.0 13.6 0.18 12.0 9.1 2.5 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.11 EFO63656.1 - 0.67 10.3 15.1 0.14 12.5 10.4 2.1 1 1 1 2 2 2 0 RING-like domain zf-Nse PF11789.8 EFO63656.1 - 0.82 9.5 7.2 1.9 8.4 7.2 1.7 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Zn_ribbon_17 PF17120.5 EFO63656.1 - 1.2 8.8 16.4 21 4.8 15.1 2.5 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 EFO63656.1 - 1.6 8.9 15.5 15 5.8 14.6 3.0 1 1 1 2 2 2 0 FANCL C-terminal domain RINGv PF12906.7 EFO63656.1 - 3.2 7.9 15.3 2.6 8.3 8.6 2.4 2 1 0 2 2 2 0 RING-variant domain Nop10p PF04135.12 EFO63657.1 - 2e-21 75.8 1.1 2.2e-21 75.6 1.1 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family PolC_DP2 PF03833.13 EFO63657.1 - 0.0091 13.9 0.8 0.0091 13.9 0.8 1.0 1 0 0 1 1 1 1 DNA polymerase II large subunit DP2 zf-ribbon_3 PF13248.6 EFO63657.1 - 0.0096 15.3 3.9 0.058 12.8 4.0 2.1 1 1 0 1 1 1 1 zinc-ribbon domain zf-ISL3 PF14690.6 EFO63657.1 - 0.022 15.4 0.5 0.022 15.4 0.5 2.1 2 1 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 DUF35_N PF12172.8 EFO63657.1 - 0.089 12.7 5.7 0.21 11.5 5.7 1.6 1 1 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Utp14 PF04615.13 EFO63658.1 - 2.4e-22 79.3 25.5 2.6e-11 42.9 12.5 3.3 1 1 1 3 3 3 3 Utp14 protein betaPIX_CC PF16523.5 EFO63658.1 - 0.12 12.2 7.3 0.028 14.3 3.0 2.2 2 0 0 2 2 2 0 betaPIX coiled coil Glucosamine_iso PF01182.20 EFO63659.1 - 5.2e-29 101.7 0.0 9.3e-29 100.9 0.0 1.3 1 1 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Sugar-bind PF04198.13 EFO63659.1 - 0.12 11.4 0.1 1.1 8.3 0.1 2.2 2 1 0 2 2 2 0 Putative sugar-binding domain Kelch_4 PF13418.6 EFO63661.1 - 9.6e-06 25.5 2.1 0.2 11.7 0.2 3.6 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.6 EFO63661.1 - 0.0092 16.3 0.7 0.53 10.6 0.1 3.3 4 0 0 4 4 4 1 Galactose oxidase, central domain Thioredoxin PF00085.20 EFO63662.1 - 1.4e-29 102.1 0.1 1.7e-29 101.8 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 EFO63662.1 - 5.1e-05 23.4 0.0 8.8e-05 22.6 0.0 1.4 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EFO63662.1 - 0.00056 20.3 0.1 0.0049 17.3 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFO63662.1 - 0.0033 17.7 0.0 0.0059 16.9 0.0 1.4 1 1 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 EFO63662.1 - 0.0049 16.8 0.0 0.0058 16.6 0.0 1.3 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFO63662.1 - 0.082 12.6 0.0 0.083 12.6 0.0 1.2 1 0 0 1 1 1 0 Redoxin GN3L_Grn1 PF08701.11 EFO63664.1 - 0.0099 16.0 0.7 0.024 14.8 0.7 1.6 1 1 0 1 1 1 1 GNL3L/Grn1 putative GTPase tRNA-synt_His PF13393.6 EFO63665.1 - 5.2e-34 117.9 0.0 1.5e-33 116.4 0.0 1.8 1 1 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EFO63665.1 - 0.00055 20.0 0.0 0.0013 18.9 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.20 EFO63665.1 - 0.018 14.2 0.0 0.044 12.9 0.0 1.6 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 EFO63665.1 - 0.043 13.3 0.0 0.089 12.3 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) Exo70 PF03081.15 EFO63666.1 - 4.1e-05 22.8 0.5 0.00035 19.8 0.1 2.3 2 0 0 2 2 2 1 Exo70 exocyst complex subunit YajC PF02699.15 EFO63667.1 - 0.91 9.4 3.3 61 3.6 0.1 4.7 4 1 1 5 5 5 0 Preprotein translocase subunit DUF4201 PF13870.6 EFO63669.1 - 8.9e-48 162.3 19.4 8.9e-48 162.3 19.4 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF4201) Uds1 PF15456.6 EFO63669.1 - 5.8e-05 23.3 6.5 5.8e-05 23.3 6.5 3.2 2 1 0 2 2 2 1 Up-regulated During Septation Prefoldin_2 PF01920.20 EFO63669.1 - 0.0061 16.5 5.4 0.0061 16.5 5.4 4.2 4 1 1 5 5 5 1 Prefoldin subunit DUF4164 PF13747.6 EFO63669.1 - 0.0082 16.4 24.3 0.11 12.8 1.5 4.6 2 1 1 4 4 4 2 Domain of unknown function (DUF4164) DUF1664 PF07889.12 EFO63669.1 - 0.06 13.4 13.8 0.67 10.0 0.3 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) DASH_Hsk3 PF08227.11 EFO63669.1 - 0.11 12.9 1.1 1.4 9.4 0.1 3.4 4 0 0 4 4 3 0 DASH complex subunit Hsk3 like bZIP_1 PF00170.21 EFO63669.1 - 0.16 12.1 32.2 0.96 9.6 0.5 6.1 6 0 0 6 6 6 0 bZIP transcription factor Csm1_N PF18504.1 EFO63669.1 - 0.22 11.9 30.0 0.53 10.7 0.6 5.9 4 1 2 6 6 6 0 Csm1 N-terminal domain NPV_P10 PF05531.12 EFO63669.1 - 0.53 10.8 13.5 0.77 10.3 0.2 4.4 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.9 EFO63669.1 - 3 8.2 19.7 0.11 12.8 1.0 4.6 3 2 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 EFO63669.1 - 3.1 7.8 18.4 6.2 6.8 3.1 4.1 2 1 3 5 5 5 0 Laminin Domain II SKA2 PF16740.5 EFO63669.1 - 5.6 6.8 19.7 0.15 11.8 1.2 4.6 2 1 1 4 4 4 0 Spindle and kinetochore-associated protein 2 KxDL PF10241.9 EFO63669.1 - 6.5 7.1 24.5 4 7.8 6.4 4.4 4 1 0 4 4 4 0 Uncharacterized conserved protein COG5 PF10392.9 EFO63669.1 - 6.7 6.9 20.3 1.6 8.9 6.2 3.6 2 1 1 3 3 3 0 Golgi transport complex subunit 5 LPP PF04728.13 EFO63669.1 - 9.8 6.7 15.2 5.5 7.5 0.5 5.1 6 2 0 6 6 4 0 Lipoprotein leucine-zipper HALZ PF02183.18 EFO63669.1 - 9.9 6.5 28.6 0.36 11.1 0.9 6.2 6 0 0 6 6 6 0 Homeobox associated leucine zipper HECT PF00632.25 EFO63670.1 - 2.2e-10 40.5 0.0 1.4e-09 37.9 0.0 2.0 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) ATP-synt_G PF04718.15 EFO63671.1 - 0.037 14.8 2.1 0.11 13.4 1.0 2.0 1 1 1 2 2 2 0 Mitochondrial ATP synthase g subunit AAA_18 PF13238.6 EFO63671.1 - 0.054 14.0 0.4 0.075 13.6 0.4 1.3 1 0 0 1 1 1 0 AAA domain SNARE PF05739.19 EFO63671.1 - 0.12 12.3 0.5 0.41 10.7 0.1 2.2 2 0 0 2 2 2 0 SNARE domain FUSC PF04632.12 EFO63671.1 - 0.46 9.0 6.3 0.56 8.7 6.3 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family HIP1_clath_bdg PF16515.5 EFO63671.1 - 1.5 9.5 8.9 0.34 11.6 1.2 2.3 1 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 SBDS PF01172.18 EFO63673.1 - 4.1e-22 78.0 0.5 6.3e-22 77.5 0.5 1.3 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 EFO63673.1 - 1e-18 67.5 0.3 3.3e-18 65.8 0.1 1.9 2 0 0 2 2 2 1 SBDS protein C-terminal domain Cyclin_N PF00134.23 EFO63674.1 - 5.3e-07 29.4 0.0 8.3e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EFO63674.1 - 0.073 13.4 0.0 0.098 13.0 0.0 1.3 1 0 0 1 1 1 0 Cyclin VMA21 PF09446.10 EFO63675.1 - 4.8e-06 26.6 4.8 6.5e-06 26.2 4.8 1.1 1 0 0 1 1 1 1 VMA21-like domain PSD5 PF07637.11 EFO63677.1 - 0.16 12.3 0.1 14 6.1 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1595) RelB_N PF18506.1 EFO63677.1 - 0.18 11.6 1.4 0.34 10.7 0.2 2.1 2 0 0 2 2 2 0 RelB Antitoxin alpha helical domain zf-CCCH PF00642.24 EFO63678.1 - 1.2e-12 47.4 18.0 4.2e-06 26.5 2.6 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFO63678.1 - 1.3e-07 31.4 19.1 0.0014 18.6 4.2 2.3 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 EFO63678.1 - 7.5e-07 29.8 9.9 0.004 17.8 2.0 2.3 1 1 1 2 2 2 2 Torus domain zf-CCCH_4 PF18044.1 EFO63678.1 - 4.7e-06 26.3 19.0 0.00084 19.1 4.2 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EFO63678.1 - 7.9 7.1 19.5 5.7 7.6 5.3 2.9 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger Abhydrolase_6 PF12697.7 EFO63679.1 - 0.15 12.6 0.0 0.23 12.0 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family VSP PF03302.13 EFO63680.1 - 1.3e-41 142.8 180.8 2.2e-34 119.0 61.9 6.2 1 1 3 5 5 5 5 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO63680.1 - 0.0037 17.4 8.7 0.0037 17.4 8.7 9.8 3 3 6 10 10 10 5 Furin-like repeat, cysteine-rich SKG6 PF08693.10 EFO63680.1 - 0.92 9.0 5.6 2.6 7.5 5.6 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Ank_2 PF12796.7 EFO63681.1 - 7e-46 154.7 4.2 7.2e-13 48.9 0.2 4.9 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EFO63681.1 - 6.3e-31 105.5 2.8 0.0012 19.2 0.0 8.9 9 0 0 9 9 8 6 Ankyrin repeat Pkinase PF00069.25 EFO63681.1 - 2.1e-30 106.0 0.0 6e-29 101.2 0.0 2.4 2 0 0 2 2 2 1 Protein kinase domain Ank_4 PF13637.6 EFO63681.1 - 9.2e-28 96.3 2.7 4.3e-06 27.2 0.0 6.6 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO63681.1 - 1.1e-23 83.0 9.0 0.00072 19.8 0.1 7.6 3 1 4 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63681.1 - 8e-22 75.0 0.7 0.47 11.2 0.0 9.4 10 0 0 10 10 8 5 Ankyrin repeat Pkinase_Tyr PF07714.17 EFO63681.1 - 6.9e-18 64.8 0.0 2.1e-17 63.3 0.0 1.8 1 0 0 1 1 1 1 Protein tyrosine kinase Spc7 PF08317.11 EFO63681.1 - 0.00062 18.7 12.1 0.001 18.0 12.1 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein HMMR_N PF15905.5 EFO63681.1 - 0.011 15.2 10.0 0.018 14.5 10.0 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal YscO PF07321.12 EFO63681.1 - 0.012 15.6 11.4 0.027 14.4 11.4 1.5 1 0 0 1 1 1 0 Type III secretion protein YscO Lectin_N PF03954.14 EFO63681.1 - 0.019 14.7 8.0 0.53 10.0 8.0 2.4 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain Fez1 PF06818.15 EFO63681.1 - 0.025 15.0 9.8 0.047 14.1 9.8 1.4 1 0 0 1 1 1 0 Fez1 Kinase-like PF14531.6 EFO63681.1 - 0.044 13.1 0.2 0.21 10.9 0.0 2.0 1 1 1 2 2 2 0 Kinase-like CENP-F_leu_zip PF10473.9 EFO63681.1 - 0.067 13.2 13.0 0.14 12.2 13.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 EFO63681.1 - 0.11 12.6 14.7 0.33 11.0 2.9 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.9 EFO63681.1 - 0.23 10.5 10.3 0.42 9.7 10.3 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 EzrA PF06160.12 EFO63681.1 - 0.29 9.3 9.7 0.45 8.6 9.7 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA DUF16 PF01519.16 EFO63681.1 - 0.3 11.6 5.2 1.5 9.3 5.2 2.2 1 1 0 1 1 1 0 Protein of unknown function DUF16 Med9 PF07544.13 EFO63681.1 - 0.42 10.7 9.5 5 7.3 2.8 2.8 1 1 2 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 GrpE PF01025.19 EFO63681.1 - 0.76 9.4 5.1 4.4 6.9 0.2 2.6 1 1 2 3 3 3 0 GrpE DUF641 PF04859.12 EFO63681.1 - 0.79 10.1 6.0 10 6.5 0.6 2.7 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Fib_alpha PF08702.10 EFO63681.1 - 1.3 9.2 10.7 0.14 12.3 2.9 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF3552 PF12072.8 EFO63681.1 - 2.9 7.3 11.4 5.5 6.4 11.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) CENP-H PF05837.12 EFO63681.1 - 4.1 7.9 9.8 4.9 7.6 2.8 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) APG6_N PF17675.1 EFO63681.1 - 4.5 7.8 12.1 27 5.3 11.9 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region OmpH PF03938.14 EFO63681.1 - 4.7 7.6 11.5 33 4.8 11.5 2.3 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) YabA PF06156.13 EFO63681.1 - 7.4 7.3 7.2 3.1e+02 2.1 7.2 2.5 1 1 0 1 1 1 0 Initiation control protein YabA Ank_2 PF12796.7 EFO63683.1 - 3.9e-76 251.7 2.9 1.2e-14 54.6 0.1 5.5 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63683.1 - 1.8e-40 136.8 7.1 3.7e-10 40.1 0.5 7.3 5 2 3 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO63683.1 - 8.8e-38 127.1 0.8 0.0038 17.6 0.0 9.5 10 0 0 10 10 10 8 Ankyrin repeat Ank_5 PF13857.6 EFO63683.1 - 2.2e-35 120.2 9.9 8.5e-05 22.8 0.0 8.8 2 1 7 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63683.1 - 4.2e-31 103.5 0.8 0.0095 16.4 0.0 10.1 10 0 0 10 10 10 7 Ankyrin repeat Pkinase PF00069.25 EFO63683.1 - 8.6e-17 61.4 0.0 3.8e-16 59.2 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63683.1 - 7.2e-12 45.1 0.0 1.2e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SnoaL_2 PF12680.7 EFO63683.1 - 0.047 14.3 0.1 0.47 11.1 0.0 2.7 3 0 0 3 3 3 0 SnoaL-like domain T3SSipB PF16535.5 EFO63683.1 - 1.5 9.3 3.8 2.5 8.6 3.8 1.3 1 0 0 1 1 1 0 Type III cell invasion protein SipB EGF PF00008.27 EFO63684.1 - 6.3e-06 26.4 45.2 0.013 15.7 5.3 5.7 4 2 2 6 6 6 3 EGF-like domain Plasmod_Pvs28 PF06247.11 EFO63684.1 - 0.00012 22.3 5.3 0.00012 22.3 5.3 4.4 4 1 1 5 5 5 2 Pvs28 EGF domain EGF_2 PF07974.13 EFO63684.1 - 0.0064 16.8 46.7 0.066 13.6 8.1 4.3 4 1 0 4 4 4 3 EGF-like domain EGF_CA PF07645.15 EFO63684.1 - 0.035 14.3 8.1 0.035 14.3 8.1 5.0 4 2 0 4 4 4 0 Calcium-binding EGF domain hEGF PF12661.7 EFO63684.1 - 0.044 14.4 6.7 0.044 14.4 6.7 6.5 7 2 1 8 8 8 0 Human growth factor-like EGF EGF_3 PF12947.7 EFO63684.1 - 0.12 12.6 37.7 0.28 11.4 8.9 4.6 4 0 0 4 4 4 0 EGF domain Calcyon PF06387.11 EFO63684.1 - 0.43 10.5 1.1 0.77 9.7 1.1 1.3 1 0 0 1 1 1 0 D1 dopamine receptor-interacting protein (calcyon) Laminin_EGF PF00053.24 EFO63684.1 - 3.1 8.0 42.5 0.24 11.6 1.9 4.7 2 2 2 4 4 4 0 Laminin EGF domain VSP PF03302.13 EFO63685.1 - 6e-78 262.4 176.6 1.6e-35 122.8 29.7 6.0 1 1 5 6 6 6 4 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO63685.1 - 0.00054 20.1 0.0 0.0019 18.3 0.0 1.9 1 0 0 1 1 1 1 Podoplanin SKG6 PF08693.10 EFO63685.1 - 0.87 9.1 5.7 1.7 8.2 5.7 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain zf-RING_5 PF14634.6 EFO63686.1 - 0.0054 16.7 3.2 0.019 14.9 3.2 2.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFO63686.1 - 0.026 14.6 0.1 0.026 14.6 0.1 2.0 2 0 0 2 2 2 0 RING-type zinc-finger RasGEF_N_2 PF14663.6 EFO63686.1 - 0.17 12.3 0.8 0.56 10.6 0.8 1.8 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain zf-RING_2 PF13639.6 EFO63686.1 - 0.38 11.1 7.3 4 7.9 7.3 2.7 1 1 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 EFO63686.1 - 0.92 9.4 6.8 0.19 11.6 0.7 2.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFO63686.1 - 0.95 9.8 5.8 0.12 12.7 0.2 2.3 3 0 0 3 3 3 0 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EFO63686.1 - 1 9.1 6.4 0.31 10.8 2.8 2.1 2 0 0 2 2 2 0 RING-like zinc finger Yip1 PF04893.17 EFO63687.1 - 7.6e-09 35.5 16.8 7.6e-09 35.5 16.8 1.7 1 1 1 2 2 2 1 Yip1 domain Pkinase PF00069.25 EFO63688.1 - 7.3e-61 205.8 0.0 1.6e-60 204.7 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63688.1 - 1.1e-41 142.8 0.0 1.6e-41 142.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFO63688.1 - 3e-08 32.8 0.0 3.3e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Seadorna_VP7 PF07387.11 EFO63688.1 - 0.0037 16.4 0.1 0.008 15.3 0.1 1.5 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 EFO63688.1 - 0.005 16.2 0.1 0.049 13.0 0.0 2.3 2 1 0 2 2 2 1 Kinase-like RIO1 PF01163.22 EFO63688.1 - 0.037 13.6 0.1 0.074 12.6 0.0 1.5 2 0 0 2 2 2 0 RIO1 family Ribosomal_L27A PF00828.19 EFO63689.1 - 6e-19 69.0 0.0 8e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A TruB_C_2 PF16198.5 EFO63690.1 - 1.9e-19 69.6 0.1 3.6e-19 68.7 0.1 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 EFO63690.1 - 6.7e-16 58.0 0.3 1e-15 57.5 0.3 1.3 1 0 0 1 1 1 1 PUA domain TruB_N PF01509.18 EFO63690.1 - 0.00021 21.7 0.0 0.0051 17.2 0.0 2.3 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) UPF0113 PF03657.13 EFO63690.1 - 0.04 14.2 0.0 0.1 12.9 0.0 1.7 2 0 0 2 2 2 0 UPF0113 PUA domain OCD_Mu_crystall PF02423.15 EFO63691.1 - 3.8e-65 219.9 3.6 4.6e-65 219.7 3.6 1.0 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 EFO63691.1 - 0.00018 21.6 0.2 0.00034 20.7 0.2 1.5 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EFO63691.1 - 0.06 13.6 0.3 0.06 13.6 0.3 1.8 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain TPR_17 PF13431.6 EFO63692.1 - 0.0022 18.2 0.9 0.04 14.3 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFO63692.1 - 0.014 15.9 0.1 0.095 13.2 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFO63692.1 - 0.13 12.4 0.2 46 4.5 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat RhoGEF67_u2 PF16614.5 EFO63692.1 - 0.18 11.9 0.5 0.92 9.6 0.0 2.3 2 0 0 2 2 2 0 Unstructured region two on RhoGEF 6 and 7 eIF-5a PF01287.20 EFO63693.1 - 4.5e-16 58.7 0.1 6.3e-16 58.2 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EFO63693.1 - 0.024 14.7 0.0 0.04 14.0 0.0 1.4 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain GTP_EFTU_D2 PF03144.25 EFO63693.1 - 0.11 12.9 0.0 0.27 11.6 0.0 1.7 2 0 0 2 2 2 0 Elongation factor Tu domain 2 BOP1NT PF08145.12 EFO63694.1 - 5.8e-30 105.1 3.7 4.9e-29 102.1 3.7 2.0 1 1 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 EFO63694.1 - 3e-12 46.9 8.7 0.011 16.5 0.1 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO63694.1 - 2.7e-08 34.0 0.0 0.0011 19.3 0.0 4.5 3 3 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.25 EFO63696.1 - 3e-73 246.4 0.0 3.4e-73 246.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63696.1 - 2.6e-33 115.4 0.0 3.2e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFO63696.1 - 0.0083 15.5 0.2 0.022 14.1 0.2 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFO63696.1 - 0.12 12.3 0.1 1.2 9.1 0.0 2.2 2 1 0 3 3 3 0 Phosphotransferase enzyme family Nucleoporin2 PF04096.14 EFO63697.1 - 1.4e-30 106.4 0.0 2.1e-30 105.8 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase EGF_2 PF07974.13 EFO63698.1 - 5.3e-16 58.7 167.2 4.8e-05 23.6 9.4 14.3 13 2 2 15 15 15 8 EGF-like domain Plasmod_Pvs28 PF06247.11 EFO63698.1 - 0.00054 20.2 2.3 0.00054 20.2 2.3 12.1 8 4 2 11 11 11 3 Pvs28 EGF domain EGF_Tenascin PF18720.1 EFO63698.1 - 0.0036 17.3 5.0 0.0036 17.3 5.0 14.1 16 2 0 16 16 16 4 Tenascin EGF domain EB PF01683.18 EFO63698.1 - 0.0038 17.5 8.1 0.0038 17.5 8.1 12.9 5 4 5 10 10 10 3 EB module EGF PF00008.27 EFO63698.1 - 0.012 15.9 3.8 0.012 15.9 3.8 14.2 14 0 0 14 14 14 0 EGF-like domain Pescadillo_N PF06732.11 EFO63699.1 - 1.7e-81 273.8 0.4 1.7e-81 273.8 0.4 2.0 2 0 0 2 2 2 2 Pescadillo N-terminus PQ-loop PF04193.14 EFO63700.1 - 3.1e-23 81.3 10.4 2.5e-14 52.8 5.6 2.5 2 0 0 2 2 2 2 PQ loop repeat DUF2759 PF10958.8 EFO63700.1 - 0.021 14.6 0.7 0.074 12.8 0.7 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2759) ER_lumen_recept PF00810.18 EFO63700.1 - 0.026 15.3 4.1 0.091 13.6 0.4 2.6 3 0 0 3 3 3 0 ER lumen protein retaining receptor MARVEL PF01284.23 EFO63700.1 - 0.38 10.8 0.1 0.38 10.8 0.1 3.3 2 1 1 3 3 3 0 Membrane-associating domain DUF2627 PF11118.8 EFO63700.1 - 0.51 10.9 3.2 6.7 7.4 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2627) ANAPC4_WD40 PF12894.7 EFO63701.1 - 0.0039 17.4 0.1 3.8 7.9 0.0 4.1 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFO63701.1 - 0.012 16.5 0.1 4.6 8.3 0.0 3.7 3 0 0 3 3 3 0 WD domain, G-beta repeat Ank_2 PF12796.7 EFO63702.1 - 2.1e-78 258.9 10.2 4.8e-16 59.1 0.0 8.6 1 1 6 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63702.1 - 1.1e-51 172.6 1.1 3.2e-08 33.9 0.0 12.7 8 4 3 11 11 11 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63702.1 - 8.4e-44 142.5 1.9 0.0011 19.2 0.0 15.9 16 0 0 16 16 16 8 Ankyrin repeat Ank_5 PF13857.6 EFO63702.1 - 4.8e-42 141.5 11.4 3.3e-05 24.1 0.0 11.7 3 3 8 12 12 12 10 Ankyrin repeats (many copies) Ank PF00023.30 EFO63702.1 - 9e-40 133.4 12.6 0.0012 19.1 0.0 14.1 14 1 1 15 15 15 9 Ankyrin repeat Pkinase PF00069.25 EFO63702.1 - 4.8e-25 88.4 0.0 1.3e-24 87.0 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63702.1 - 5.3e-17 61.9 0.0 8.1e-17 61.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Phage_T7_Capsid PF05396.11 EFO63702.1 - 0.02 15.2 0.1 3.6 8.0 0.0 2.9 2 0 0 2 2 2 0 Phage T7 capsid assembly protein DUF848 PF05852.11 EFO63702.1 - 0.096 12.8 0.1 0.2 11.8 0.1 1.4 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) HemY_N PF07219.13 EFO63702.1 - 0.1 12.8 0.1 25 5.1 0.0 3.1 2 0 0 2 2 2 0 HemY protein N-terminus PIN_3 PF13470.6 EFO63702.1 - 0.12 13.1 2.0 5.1 7.9 0.2 3.1 3 0 0 3 3 3 0 PIN domain HOOK PF05622.12 EFO63702.1 - 0.16 10.1 0.3 0.26 9.4 0.3 1.3 1 0 0 1 1 1 0 HOOK protein DUF2968 PF11180.8 EFO63702.1 - 0.21 11.2 0.2 0.34 10.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) bMG3 PF11974.8 EFO63702.1 - 0.51 10.4 2.7 3.9 7.6 0.0 3.4 4 0 0 4 4 4 0 Bacterial alpha-2-macroglobulin MG3 domain PH_8 PF15409.6 EFO63703.1 - 0.088 13.1 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain SNAD4 PF18750.1 EFO63704.1 - 0.041 14.0 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 NAD2 PF18782.1 EFO63704.1 - 0.082 13.0 0.3 0.21 11.7 0.0 1.7 2 0 0 2 2 2 0 Novel AID APOBEC clade 2 Nup84_Nup100 PF04121.13 EFO63705.1 - 6.8e-13 47.6 0.0 5.1e-10 38.1 0.0 2.3 1 1 1 2 2 2 2 Nuclear pore protein 84 / 107 TPR_8 PF13181.6 EFO63705.1 - 0.056 13.7 3.9 0.15 12.4 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFO63705.1 - 0.063 13.3 0.9 3 8.1 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFO63705.1 - 0.13 12.4 0.1 0.13 12.4 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFO63705.1 - 0.24 12.1 4.5 2.3 9.1 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.20 EFO63705.1 - 0.25 11.7 1.0 34 5.0 0.1 2.7 2 0 0 2 2 2 0 PPR repeat Dus PF01207.17 EFO63708.1 - 2.1e-28 99.3 0.0 8.9e-28 97.3 0.0 1.8 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) PGM_PMM_I PF02878.16 EFO63709.1 - 6e-32 110.2 0.0 1.1e-31 109.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EFO63709.1 - 2.5e-10 40.9 0.0 2.3e-09 37.8 0.0 2.5 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EFO63709.1 - 1.2e-06 28.7 0.0 2.3e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EFO63709.1 - 1.7e-05 24.9 0.0 3.9e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain DUF92 PF01940.16 EFO63710.1 - 4.4e-41 140.9 4.2 4.4e-41 140.9 4.2 1.9 2 0 0 2 2 2 1 Integral membrane protein DUF92 TRAPP PF04051.16 EFO63711.1 - 2.1e-21 76.2 0.0 2.4e-21 76.0 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component ABC_tran PF00005.27 EFO63713.1 - 3e-37 128.2 0.0 2.6e-19 70.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 EFO63713.1 - 1e-18 67.6 45.3 9.2e-11 41.4 17.7 2.7 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 EFO63713.1 - 3e-13 50.3 6.6 0.00028 20.8 0.0 4.3 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFO63713.1 - 9.9e-06 25.2 1.1 0.022 14.5 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFO63713.1 - 2e-05 24.6 0.3 0.013 15.4 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase SMC_N PF02463.19 EFO63713.1 - 8.1e-05 22.1 0.1 0.44 9.9 0.2 3.8 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFO63713.1 - 0.0018 18.7 0.1 0.31 11.4 0.1 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 EFO63713.1 - 0.0036 17.8 0.3 0.49 10.9 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EFO63713.1 - 0.018 14.7 2.7 1.3 8.7 0.0 3.4 4 0 0 4 4 4 0 AAA ATPase domain AAA_22 PF13401.6 EFO63713.1 - 0.025 14.8 0.0 7.3 6.9 0.0 3.0 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EFO63713.1 - 0.026 14.6 1.3 1.5 8.9 0.2 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA PF00004.29 EFO63713.1 - 0.046 14.2 0.0 15 6.0 0.0 3.5 2 2 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.22 EFO63713.1 - 0.075 12.7 0.2 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain cobW PF02492.19 EFO63713.1 - 0.097 12.3 0.2 3.2 7.3 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 EFO63713.1 - 0.18 11.3 0.1 5.3 6.6 0.1 2.7 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 EFO63713.1 - 0.2 11.3 0.6 6 6.5 0.1 2.3 2 0 0 2 2 2 0 AAA domain Bromodomain PF00439.25 EFO63714.1 - 0.0013 18.8 1.0 0.0034 17.4 0.7 1.9 1 1 0 1 1 1 1 Bromodomain DUF4930 PF16284.5 EFO63714.1 - 0.0099 15.9 0.3 0.016 15.2 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4930) tRNA_bind PF01588.20 EFO63716.1 - 1.1e-16 60.7 0.0 1.6e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Putative tRNA binding domain Filament PF00038.21 EFO63717.1 - 0.00032 20.4 9.6 0.00032 20.4 9.6 2.6 1 1 1 2 2 2 1 Intermediate filament protein Jnk-SapK_ap_N PF09744.9 EFO63717.1 - 0.014 15.6 18.6 0.014 15.6 18.6 4.8 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 CCDC144C PF14915.6 EFO63717.1 - 0.022 13.9 60.1 0.096 11.8 17.7 3.7 2 1 2 4 4 4 0 CCDC144C protein coiled-coil region Bacillus_HBL PF05791.11 EFO63717.1 - 0.028 14.3 0.2 0.028 14.3 0.2 4.6 2 2 2 5 5 5 0 Bacillus haemolytic enterotoxin (HBL) DUF4407 PF14362.6 EFO63717.1 - 1.6 8.0 41.7 0.48 9.7 12.5 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) Laminin_II PF06009.12 EFO63717.1 - 1.8 8.6 30.6 14 5.7 0.8 4.8 2 2 3 5 5 5 0 Laminin Domain II Rab5-bind PF09311.11 EFO63717.1 - 1.8 7.9 45.4 3 7.1 12.6 3.8 2 1 1 3 3 3 0 Rabaptin-like protein DUF2353 PF09789.9 EFO63717.1 - 2 7.7 47.6 0.095 12.0 13.5 3.1 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) DUF2937 PF11157.8 EFO63717.1 - 4.8 6.9 7.7 0.49 10.1 2.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) DUF1664 PF07889.12 EFO63717.1 - 7 6.7 24.1 6.3 6.9 4.7 4.4 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 EFO63717.1 - 7.3 5.4 57.3 0.11 11.3 12.7 4.5 1 1 3 4 4 4 0 Spc7 kinetochore protein adh_short PF00106.25 EFO63720.1 - 2.9e-22 79.1 0.0 4e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFO63720.1 - 1e-09 38.4 0.0 1.4e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFO63720.1 - 0.00091 19.2 0.0 0.0022 17.9 0.0 1.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EFO63720.1 - 0.044 13.2 0.0 0.067 12.6 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family WD40 PF00400.32 EFO63721.1 - 2.2e-59 196.0 16.3 2.6e-11 43.9 0.0 8.9 8 2 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO63721.1 - 3.9e-18 65.5 0.1 0.042 14.2 0.0 5.5 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 EFO63721.1 - 9.2e-08 32.5 0.0 1.7e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain Ge1_WD40 PF16529.5 EFO63721.1 - 3.4e-07 29.6 0.0 0.66 8.9 0.0 4.3 3 1 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EFO63721.1 - 1e-06 28.8 0.0 0.01 15.7 0.0 3.2 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EFO63721.1 - 0.0001 21.7 0.3 5.9 6.1 0.1 3.9 2 1 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 EFO63721.1 - 0.00019 20.2 4.0 0.51 8.9 0.0 3.9 3 1 0 4 4 4 2 Nucleoporin Nup120/160 Nbas_N PF15492.6 EFO63721.1 - 0.0035 16.7 0.0 9.7 5.4 0.0 4.1 2 2 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 EFO63721.1 - 0.0087 14.6 0.1 0.24 9.9 0.1 2.3 2 0 0 2 2 2 1 Cytochrome D1 heme domain BBS2_Mid PF14783.6 EFO63721.1 - 0.12 12.4 0.1 18 5.4 0.0 3.6 3 1 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Mt_ATP-synt_B PF05405.14 EFO63722.1 - 0.0036 17.0 0.5 0.0081 15.8 0.5 1.5 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) HEAT PF02985.22 EFO63722.1 - 0.15 12.4 0.3 20 5.8 0.1 3.1 2 0 0 2 2 2 0 HEAT repeat AAA PF00004.29 EFO63723.1 - 1.4e-36 125.8 0.0 2.5e-36 125.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFO63723.1 - 3.7e-11 42.6 1.8 1.1e-10 41.1 0.2 2.5 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 EFO63723.1 - 6.7e-06 26.6 1.6 0.0003 21.2 0.1 2.5 2 1 1 3 3 2 1 AAA ATPase domain AAA_22 PF13401.6 EFO63723.1 - 8.7e-05 22.8 0.8 0.0095 16.2 0.1 2.5 1 1 1 2 2 2 1 AAA domain Prot_ATP_ID_OB PF16450.5 EFO63723.1 - 0.00088 19.2 0.0 0.0016 18.3 0.0 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_18 PF13238.6 EFO63723.1 - 0.0009 19.8 0.0 0.003 18.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EFO63723.1 - 0.006 16.3 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EFO63723.1 - 0.007 15.5 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 EFO63723.1 - 0.0082 16.5 0.0 0.034 14.5 0.0 2.0 2 0 0 2 2 2 1 RNA helicase AAA_2 PF07724.14 EFO63723.1 - 0.0087 16.2 0.0 0.028 14.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.6 EFO63723.1 - 0.0089 16.5 0.0 0.022 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFO63723.1 - 0.016 15.4 0.0 0.028 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EFO63723.1 - 0.023 14.7 0.0 0.076 13.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 EFO63723.1 - 0.03 13.6 0.5 0.17 11.2 0.0 2.3 3 0 0 3 3 3 0 KaiC Mg_chelatase PF01078.21 EFO63723.1 - 0.047 13.1 0.0 0.084 12.2 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EFO63723.1 - 0.051 13.6 0.0 0.097 12.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EFO63723.1 - 0.07 13.2 0.0 0.19 11.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EFO63723.1 - 0.078 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 EFO63723.1 - 0.12 12.3 0.5 6.1 6.7 0.1 2.2 1 1 1 2 2 2 0 NACHT domain Cytidylate_kin PF02224.18 EFO63723.1 - 0.13 12.0 0.1 0.22 11.2 0.1 1.4 1 0 0 1 1 1 0 Cytidylate kinase AAA_24 PF13479.6 EFO63723.1 - 0.13 12.0 0.1 0.3 10.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFO63723.1 - 0.16 11.5 0.0 0.28 10.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 EFO63723.1 - 0.2 11.2 0.2 0.86 9.1 0.1 2.0 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EFO63723.1 - 0.22 11.4 0.7 0.48 10.3 0.2 1.7 2 0 0 2 2 2 0 Rad17 P-loop domain Synaptobrevin PF00957.21 EFO63724.1 - 3.3e-11 42.8 0.6 5.1e-11 42.2 0.6 1.3 1 0 0 1 1 1 1 Synaptobrevin Topo-VIb_trans PF09239.11 EFO63724.1 - 0.016 15.1 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 Topoisomerase VI B subunit, transducer PsbK PF02533.15 EFO63725.1 - 0.14 12.3 0.1 0.35 11.1 0.1 1.6 1 0 0 1 1 1 0 Photosystem II 4 kDa reaction centre component SNARE PF05739.19 EFO63726.1 - 1.5e-10 40.9 1.6 5.2e-10 39.2 1.6 1.9 1 0 0 1 1 1 1 SNARE domain DUF4404 PF14357.6 EFO63726.1 - 0.02 15.5 2.3 0.02 15.5 2.3 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) GMP_synt_C PF00958.22 EFO63726.1 - 0.049 13.7 0.1 0.2 11.7 0.1 2.1 1 1 0 1 1 1 0 GMP synthase C terminal domain CtsR_C PF17727.1 EFO63726.1 - 0.064 13.4 4.1 0.45 10.7 1.1 3.1 3 0 0 3 3 3 0 CtsR C-terminal dimerization domain DASH_Dad3 PF08656.10 EFO63726.1 - 0.096 12.8 1.7 1.5 9.0 0.0 2.9 2 1 0 2 2 2 0 DASH complex subunit Dad3 DUF2390 PF09523.10 EFO63726.1 - 0.13 12.6 7.8 1.5 9.2 2.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2390) ParBc PF02195.18 EFO63726.1 - 0.13 12.6 2.0 0.3 11.4 0.5 2.4 2 1 0 2 2 2 0 ParB-like nuclease domain CwsA PF10814.8 EFO63726.1 - 0.18 12.0 0.2 0.18 12.0 0.2 2.4 2 1 2 4 4 4 0 Cell wall synthesis protein CwsA DUF4263 PF14082.6 EFO63726.1 - 0.18 12.1 2.5 0.93 9.7 0.8 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4263) UPF0258 PF06789.12 EFO63726.1 - 0.27 11.3 2.9 0.68 10.1 2.9 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) FUSC PF04632.12 EFO63726.1 - 0.28 9.6 0.5 0.31 9.5 0.5 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF5345 PF17280.2 EFO63726.1 - 1.1 9.3 4.2 5.6 7.0 0.0 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5345) Laminin_II PF06009.12 EFO63726.1 - 8.1 6.5 13.9 0.85 9.6 0.8 3.2 2 1 1 3 3 3 0 Laminin Domain II Glyco_tran_28_C PF04101.16 EFO63727.1 - 0.24 11.4 0.0 0.26 11.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain AAA_6 PF12774.7 EFO63728.1 - 1.2e-148 494.5 1.2 5.8e-147 488.9 0.0 3.3 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFO63728.1 - 5.1e-102 341.9 1.7 5.1e-102 341.9 1.7 3.6 2 1 0 2 2 1 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 EFO63728.1 - 1.8e-85 286.4 0.1 3e-84 282.4 0.0 3.0 2 1 0 2 2 2 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 EFO63728.1 - 2.4e-80 270.1 0.4 7.5e-80 268.4 0.0 2.2 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 EFO63728.1 - 9.5e-76 253.8 3.7 9.5e-76 253.8 3.7 4.3 5 1 0 5 5 4 2 ATP-binding dynein motor region DHC_N1 PF08385.12 EFO63728.1 - 6.6e-73 246.2 14.3 6e-35 120.9 0.1 4.9 4 0 0 4 4 4 3 Dynein heavy chain, N-terminal region 1 AAA_lid_11 PF18198.1 EFO63728.1 - 5.5e-56 188.9 0.2 1.3e-55 187.7 0.2 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 EFO63728.1 - 3.5e-47 161.1 9.1 3.5e-47 161.1 9.1 2.2 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.7 EFO63728.1 - 2.2e-44 151.1 1.4 2.1e-32 112.1 0.0 6.4 5 1 1 6 6 6 4 P-loop containing dynein motor region Dynein_heavy PF03028.15 EFO63728.1 - 1e-38 132.0 1.2 2.4e-37 127.6 0.0 3.7 4 0 0 4 4 2 1 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 EFO63728.1 - 6.7e-18 65.0 0.1 3.2e-17 62.8 0.1 2.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 EFO63728.1 - 9.6e-16 57.8 0.2 1.2e-14 54.3 0.0 3.2 2 0 0 2 2 1 1 AAA+ lid domain AAA_5 PF07728.14 EFO63728.1 - 4.1e-15 56.0 1.4 0.0085 16.1 0.0 7.7 7 1 0 7 7 7 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFO63728.1 - 8.4e-09 36.0 7.1 0.075 13.4 0.0 6.8 6 0 0 6 6 5 3 AAA ATPase domain AAA PF00004.29 EFO63728.1 - 9.6e-08 32.5 2.1 0.46 10.9 0.0 5.4 5 0 0 5 5 4 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFO63728.1 - 2.4e-07 31.1 2.4 0.52 10.6 0.0 5.5 4 0 0 4 4 4 1 AAA domain AAA_18 PF13238.6 EFO63728.1 - 0.00027 21.5 0.1 17 6.0 0.0 5.0 5 0 0 5 5 3 0 AAA domain RNA_helicase PF00910.22 EFO63728.1 - 0.00073 19.9 0.2 15 6.1 0.0 4.1 4 0 0 4 4 3 0 RNA helicase ABC_tran PF00005.27 EFO63728.1 - 0.0026 18.3 0.2 13 6.3 0.0 4.5 3 0 0 3 3 3 0 ABC transporter DUF4968 PF16338.5 EFO63728.1 - 0.0028 17.9 0.7 0.0096 16.2 0.2 2.2 2 0 0 2 2 1 1 Domain of unknown function (DUF4968) DUF815 PF05673.13 EFO63728.1 - 0.0033 16.6 0.2 7.9 5.6 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 EFO63728.1 - 0.0054 16.4 1.8 3 7.7 0.0 3.5 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_24 PF13479.6 EFO63728.1 - 0.0061 16.3 5.5 2.6 7.7 0.1 4.8 4 0 0 4 4 4 1 AAA domain AAA_33 PF13671.6 EFO63728.1 - 0.0067 16.6 0.2 1.7 8.8 0.0 3.9 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EFO63728.1 - 0.011 15.4 5.9 3.9 7.1 0.2 4.2 4 0 0 4 4 4 0 AAA domain TrwB_AAD_bind PF10412.9 EFO63728.1 - 0.062 12.2 1.4 2.4 6.9 0.0 3.4 4 0 0 4 4 4 0 Type IV secretion-system coupling protein DNA-binding domain Ish1 PF10281.9 EFO63728.1 - 0.077 13.3 1.4 0.29 11.5 0.0 2.8 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein NYD-SP28_assoc PF14775.6 EFO63728.1 - 0.087 12.9 0.9 3.4 7.8 0.0 4.0 4 0 0 4 4 3 0 Sperm tail C-terminal domain Sigma54_activat PF00158.26 EFO63728.1 - 0.091 12.5 0.9 3.4 7.3 0.1 3.2 4 0 0 4 4 4 0 Sigma-54 interaction domain Roc PF08477.13 EFO63728.1 - 0.092 13.0 0.1 23 5.2 0.0 3.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF745 PF05335.13 EFO63728.1 - 0.27 10.9 23.3 0.078 12.7 6.2 4.4 3 0 0 3 3 3 0 Protein of unknown function (DUF745) PduV-EutP PF10662.9 EFO63728.1 - 0.3 10.8 1.5 10 5.9 0.0 3.6 4 0 0 4 4 3 0 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.6 EFO63728.1 - 0.31 11.3 1.8 28 4.9 0.0 4.0 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 EFO63729.1 - 7.6e-35 120.2 0.0 2.3e-25 89.6 0.0 3.3 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFO63729.1 - 1.5e-08 34.3 1.6 3.5e-06 26.7 0.2 2.5 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 EFO63729.1 - 1e-07 32.5 0.5 0.0022 18.4 0.0 3.9 2 2 1 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 EFO63729.1 - 1.2e-05 25.7 0.1 0.71 10.1 0.0 4.4 3 2 1 4 4 4 1 AAA domain AAA_5 PF07728.14 EFO63729.1 - 1.2e-05 25.4 0.0 0.0025 17.8 0.0 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EFO63729.1 - 4.3e-05 23.8 0.0 0.041 14.3 0.0 2.8 2 1 0 2 2 2 1 RNA helicase AAA_18 PF13238.6 EFO63729.1 - 0.00016 22.2 0.0 0.028 15.0 0.0 2.7 2 1 0 2 2 2 1 AAA domain DUF815 PF05673.13 EFO63729.1 - 0.00017 20.9 0.0 0.031 13.4 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 EFO63729.1 - 0.0016 17.8 0.1 1.1 8.6 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EFO63729.1 - 0.0047 16.6 0.0 2.2 7.9 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain ATPase_2 PF01637.18 EFO63729.1 - 0.0062 16.5 0.0 0.31 10.9 0.0 2.7 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_33 PF13671.6 EFO63729.1 - 0.01 16.0 0.0 9.6 6.4 0.0 3.1 3 0 0 3 3 3 0 AAA domain TniB PF05621.11 EFO63729.1 - 0.01 15.2 0.0 3.2 7.1 0.0 2.5 2 0 0 2 2 2 0 Bacterial TniB protein DAP3 PF10236.9 EFO63729.1 - 0.02 14.1 0.1 2.6 7.2 0.0 2.4 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 RuvB_N PF05496.12 EFO63729.1 - 0.027 14.2 0.0 4.6 7.0 0.0 2.5 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 EFO63729.1 - 0.032 13.7 0.0 4.5 6.8 0.0 2.7 2 1 0 2 2 2 0 P-loop containing dynein motor region AAA_24 PF13479.6 EFO63729.1 - 0.04 13.6 0.0 4.8 6.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EFO63729.1 - 0.096 12.0 0.0 4 6.7 0.0 2.7 3 0 0 3 3 3 0 KaiC NACHT PF05729.12 EFO63729.1 - 0.1 12.5 0.1 49 3.8 0.0 3.6 3 1 1 4 4 4 0 NACHT domain SKI PF01202.22 EFO63729.1 - 0.15 12.2 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 Shikimate kinase AAA_10 PF12846.7 EFO63729.1 - 0.21 10.4 0.0 2.5 6.9 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain zf-CHY PF05495.12 EFO63732.1 - 1.8e-11 44.3 11.2 4.2e-11 43.2 11.2 1.6 1 1 0 1 1 1 1 CHY zinc finger ADK_lid PF05191.14 EFO63732.1 - 0.0021 18.0 0.7 0.0021 18.0 0.7 1.7 2 0 0 2 2 2 1 Adenylate kinase, active site lid zinc_ribbon_4 PF13717.6 EFO63732.1 - 0.005 16.7 4.1 0.005 16.7 4.1 2.8 2 2 0 2 2 2 1 zinc-ribbon domain Zn-ribbon_8 PF09723.10 EFO63732.1 - 0.036 14.2 4.9 0.053 13.6 1.2 2.5 2 0 0 2 2 2 0 Zinc ribbon domain tRNA-synt_1f PF01921.18 EFO63732.1 - 0.12 11.3 0.6 0.13 11.1 0.6 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) Elf1 PF05129.13 EFO63732.1 - 0.13 12.4 9.6 1.1 9.3 10.3 2.2 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like SIR2 PF02146.17 EFO63732.1 - 0.37 10.7 1.9 0.53 10.2 1.9 1.3 1 0 0 1 1 1 0 Sir2 family zinc-ribbons_6 PF07191.12 EFO63732.1 - 0.67 10.0 9.9 0.78 9.8 4.3 2.3 1 1 1 2 2 2 0 zinc-ribbons eIF-5_eIF-2B PF01873.17 EFO63732.1 - 5.4 6.9 8.9 9.2 6.2 8.9 1.4 1 0 0 1 1 1 0 Domain found in IF2B/IF5 VSP PF03302.13 EFO63733.1 - 6.2e-13 48.4 173.4 1.1e-07 31.1 57.9 5.8 1 1 2 3 3 3 3 Giardia variant-specific surface protein P_proprotein PF01483.20 EFO63734.1 - 0.00015 21.7 0.0 0.00062 19.7 0.0 2.0 2 0 0 2 2 2 1 Proprotein convertase P-domain PEHE PF15275.6 EFO63736.1 - 0.0043 17.7 1.0 0.013 16.2 1.0 1.8 1 0 0 1 1 1 1 PEHE domain Zn_ribbon_17 PF17120.5 EFO63737.1 - 0.27 10.9 11.7 0.49 10.0 11.7 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 EFO63737.1 - 0.54 10.6 15.6 0.076 13.3 11.3 1.8 2 0 0 2 2 2 0 RING-like domain zf-RING_2 PF13639.6 EFO63737.1 - 1.4 9.3 12.8 3 8.2 12.8 1.6 1 0 0 1 1 1 0 Ring finger domain Spc29 PF17082.5 EFO63738.1 - 0.0027 17.6 1.9 0.0027 17.6 1.9 2.1 1 1 2 3 3 3 1 Spindle Pole Component 29 Viral_env_E26 PF11050.8 EFO63738.1 - 0.02 14.3 1.4 2 7.8 0.1 2.8 2 1 0 3 3 3 0 Virus envelope protein E26 Flu_B_M2 PF04772.12 EFO63738.1 - 0.036 14.3 1.2 0.28 11.4 0.4 2.5 1 1 1 2 2 2 0 Influenza B matrix protein 2 (BM2) PARP_regulatory PF01358.18 EFO63738.1 - 0.038 12.9 3.4 0.13 11.1 0.1 2.1 2 0 0 2 2 2 0 Poly A polymerase regulatory subunit Lar_N PF09861.9 EFO63738.1 - 0.08 12.1 0.3 0.16 11.1 0.3 1.4 1 0 0 1 1 1 0 Lactate racemase N-terminal domain KLRAQ PF10205.9 EFO63738.1 - 0.095 12.9 0.4 0.095 12.9 0.4 3.4 3 0 0 3 3 3 0 Predicted coiled-coil domain-containing protein LOH1CR12 PF10158.9 EFO63738.1 - 0.1 12.6 7.8 0.5 10.4 1.1 3.2 2 1 1 3 3 3 0 Tumour suppressor protein NRBF2 PF08961.10 EFO63738.1 - 0.15 11.7 12.6 0.42 10.2 0.8 3.6 3 1 0 3 3 3 0 Nuclear receptor-binding factor 2, autophagy regulator DUF1664 PF07889.12 EFO63738.1 - 0.24 11.4 13.7 0.57 10.2 1.4 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) ZapB PF06005.12 EFO63738.1 - 0.38 11.2 26.8 0.12 12.8 1.4 5.3 3 2 1 5 5 5 0 Cell division protein ZapB DUF5082 PF16888.5 EFO63738.1 - 0.45 10.8 12.6 0.75 10.1 6.9 3.5 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) Syntaxin-6_N PF09177.11 EFO63738.1 - 0.96 10.0 15.1 12 6.5 5.5 3.7 1 1 2 3 3 3 0 Syntaxin 6, N-terminal Occludin_ELL PF07303.13 EFO63738.1 - 1.5 9.6 9.1 1.2 9.9 0.5 3.5 2 2 1 3 3 3 0 Occludin homology domain ING PF12998.7 EFO63738.1 - 1.7 9.3 12.1 0.74 10.4 0.3 3.4 3 1 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding YabA PF06156.13 EFO63738.1 - 1.8 9.3 21.8 0.23 12.1 1.2 4.3 2 2 2 4 4 4 0 Initiation control protein YabA TMF_TATA_bd PF12325.8 EFO63738.1 - 3 8.1 26.8 6.6 7.0 3.0 4.8 2 2 2 4 4 4 0 TATA element modulatory factor 1 TATA binding Spc42p PF11544.8 EFO63738.1 - 3.3 7.8 12.0 5.7 7.0 0.1 4.2 5 0 0 5 5 4 0 Spindle pole body component Spc42p FlaC_arch PF05377.11 EFO63738.1 - 7.2 7.1 15.0 37 4.8 0.2 5.7 3 2 3 6 6 6 0 Flagella accessory protein C (FlaC) CENP-H PF05837.12 EFO63738.1 - 8.6 6.8 20.6 0.22 11.9 2.6 3.9 2 1 2 4 4 4 0 Centromere protein H (CENP-H) FapA PF03961.13 EFO63738.1 - 8.8 4.8 15.6 2.3 6.7 3.7 2.8 1 1 2 3 3 3 0 Flagellar Assembly Protein A WD40 PF00400.32 EFO63739.1 - 3.5e-26 90.9 26.2 5e-07 30.3 0.0 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO63739.1 - 4.4e-10 39.7 0.6 0.019 15.3 0.0 5.1 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Spc7 PF08317.11 EFO63739.1 - 0.00093 18.2 2.2 0.0015 17.5 2.2 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Frtz PF11768.8 EFO63739.1 - 0.0023 16.3 2.3 0.89 7.8 0.2 3.0 2 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.5 EFO63739.1 - 0.017 14.1 0.8 0.37 9.7 0.0 2.6 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EFO63739.1 - 0.03 13.0 10.6 0.26 9.9 0.3 3.9 2 1 2 4 4 4 0 Nucleoporin Nup120/160 ZapB PF06005.12 EFO63739.1 - 0.045 14.2 2.3 3.5 8.1 1.0 2.4 2 0 0 2 2 2 0 Cell division protein ZapB DUF3053 PF11254.8 EFO63739.1 - 0.053 13.1 1.0 0.15 11.6 1.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3053) Prenylcys_lyase PF07156.14 EFO63739.1 - 0.13 11.4 0.1 0.23 10.5 0.1 1.3 1 0 0 1 1 1 0 Prenylcysteine lyase JAKMIP_CC3 PF16034.5 EFO63739.1 - 0.61 10.0 6.9 0.21 11.5 1.3 2.4 1 1 1 2 2 2 0 JAKMIP CC3 domain Suppressor_APC PF11414.8 EFO63739.1 - 0.67 10.1 4.4 0.57 10.3 0.8 2.6 3 0 0 3 3 3 0 Adenomatous polyposis coli tumour suppressor protein DivIC PF04977.15 EFO63739.1 - 2 8.3 5.7 2.6 7.9 1.4 2.4 2 0 0 2 2 2 0 Septum formation initiator Cep57_CLD_2 PF14197.6 EFO63739.1 - 8.3 6.6 10.3 1.1 9.4 2.8 2.6 1 1 2 3 3 3 0 Centrosome localisation domain of PPC89 Abhydrolase_6 PF12697.7 EFO63740.1 - 0.0035 18.0 0.0 0.0072 16.9 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFO63740.1 - 0.0098 15.6 0.0 0.019 14.6 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold PrpR_N PF06506.11 EFO63740.1 - 0.016 14.8 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 Propionate catabolism activator SDH_alpha PF03313.15 EFO63740.1 - 0.16 11.6 0.0 0.35 10.5 0.0 1.5 1 0 0 1 1 1 0 Serine dehydratase alpha chain MMR_HSR1 PF01926.23 EFO63741.1 - 8.6e-17 61.3 0.1 1.6e-12 47.5 0.0 2.6 3 0 0 3 3 3 2 50S ribosome-binding GTPase GN3L_Grn1 PF08701.11 EFO63741.1 - 8.3e-10 38.6 8.7 1.6e-09 37.7 7.7 2.0 2 0 0 2 2 2 1 GNL3L/Grn1 putative GTPase FeoB_N PF02421.18 EFO63741.1 - 9.6e-08 31.7 0.0 4.4e-05 23.0 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFO63741.1 - 0.00027 20.9 0.0 0.28 11.1 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFO63741.1 - 0.00046 19.8 0.1 0.0015 18.1 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EFO63741.1 - 0.085 12.9 4.6 0.11 12.5 0.3 2.8 2 2 1 3 3 3 0 Dynamin family Flg_bbr_C PF06429.13 EFO63741.1 - 0.11 12.6 0.0 0.31 11.2 0.0 1.8 1 0 0 1 1 1 0 Flagellar basal body rod FlgEFG protein C-terminal AAA_18 PF13238.6 EFO63741.1 - 0.19 12.3 0.0 0.19 12.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain CH PF00307.31 EFO63742.1 - 3.1e-05 24.1 0.0 0.057 13.6 0.0 4.1 5 0 0 5 5 5 2 Calponin homology (CH) domain Ank_2 PF12796.7 EFO63743.1 - 2.4e-61 204.3 11.0 7.6e-13 48.9 0.1 6.6 2 2 4 6 6 6 5 Ankyrin repeats (3 copies) Ank PF00023.30 EFO63743.1 - 2.4e-33 113.1 11.1 0.0034 17.7 0.0 11.1 10 1 1 11 11 11 8 Ankyrin repeat Ank_5 PF13857.6 EFO63743.1 - 6.2e-32 109.2 13.6 7e-06 26.2 0.1 10.0 3 2 7 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63743.1 - 3.2e-28 94.6 11.7 0.012 16.0 0.0 11.2 11 0 0 11 11 11 7 Ankyrin repeat Ank_4 PF13637.6 EFO63743.1 - 1.3e-27 95.8 15.2 0.00036 21.1 0.2 8.4 5 2 3 8 8 8 7 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO63743.1 - 1.8e-15 57.1 1.9 2.2e-07 30.5 0.1 3.4 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63743.1 - 1.1e-07 31.4 0.5 0.004 16.5 0.1 3.4 2 1 0 2 2 2 2 Protein tyrosine kinase CBS PF00571.28 EFO63744.1 - 0.0075 16.7 0.0 0.019 15.4 0.0 1.7 1 0 0 1 1 1 1 CBS domain DUF485 PF04341.12 EFO63744.1 - 0.046 13.7 1.0 0.51 10.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF485 TMEM95 PF15203.6 EFO63744.1 - 0.2 11.3 1.0 0.43 10.2 0.1 1.9 2 0 0 2 2 2 0 TMEM95 family Pkinase PF00069.25 EFO63745.1 - 3e-43 148.1 0.0 4.4e-43 147.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63745.1 - 6.1e-20 71.6 0.0 9.2e-20 71.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EFO63745.1 - 8.5e-05 22.2 0.7 0.009 15.6 0.0 2.6 3 0 0 3 3 3 1 RIO1 family Kinase-like PF14531.6 EFO63745.1 - 0.00017 21.0 0.0 0.00029 20.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFO63745.1 - 0.0028 16.5 0.0 0.0028 16.5 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EFO63745.1 - 0.031 14.2 0.0 0.095 12.6 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF4761 PF15958.5 EFO63745.1 - 0.1 12.7 0.1 4.1 7.6 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4761) Choline_kinase PF01633.20 EFO63745.1 - 0.14 11.7 0.0 0.32 10.5 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF4394 PF14339.6 EFO63746.1 - 0.0061 15.9 0.0 0.009 15.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4394) ANAPC4_WD40 PF12894.7 EFO63746.1 - 0.078 13.3 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain NOB1_Zn_bind PF08772.11 EFO63747.1 - 9e-15 54.6 1.4 2.5e-14 53.2 0.3 2.2 2 0 0 2 2 2 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 EFO63747.1 - 5.4e-14 52.4 0.0 8e-13 48.7 0.0 2.5 2 0 0 2 2 2 1 PIN domain of ribonuclease amfpi-1 PF12190.8 EFO63747.1 - 0.064 13.9 0.8 0.16 12.6 0.8 1.7 1 1 0 1 1 1 0 Fungal protease inhibitor SF-assemblin PF06705.11 EFO63748.1 - 5.5e-09 35.7 16.0 1.5e-07 31.1 12.7 2.0 1 1 1 2 2 2 2 SF-assemblin/beta giardin Apolipoprotein PF01442.18 EFO63748.1 - 2.9e-06 27.3 14.3 3.2e-05 23.9 13.4 2.4 1 1 1 2 2 2 1 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.11 EFO63748.1 - 0.00055 20.0 5.2 1.6 8.8 5.6 2.4 1 1 1 2 2 2 2 Apolipophorin-III precursor (apoLp-III) DUF885 PF05960.11 EFO63748.1 - 0.0013 18.5 7.4 0.0027 17.4 6.0 1.7 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF885) DUF4099 PF13351.6 EFO63748.1 - 0.0014 18.8 0.5 0.028 14.7 0.2 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF4099) FadA PF09403.10 EFO63748.1 - 0.0016 18.8 9.7 0.0016 18.8 9.7 3.6 1 1 3 4 4 4 1 Adhesion protein FadA CRISPR_Cas9_WED PF18061.1 EFO63748.1 - 0.033 14.3 1.4 4.8 7.3 0.4 2.3 1 1 1 2 2 2 0 CRISPR-Cas9 WED domain PRESAN PF09687.10 EFO63748.1 - 0.034 14.7 3.5 1.8 9.1 0.2 2.9 2 1 1 3 3 3 0 Plasmodium RESA N-terminal Baculo_PEP_C PF04513.12 EFO63748.1 - 0.036 14.1 8.2 7.5 6.6 0.1 3.3 1 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Noelin-1 PF12308.8 EFO63748.1 - 0.046 13.7 3.5 0.094 12.7 0.4 2.8 1 1 2 3 3 3 0 Neurogenesis glycoprotein DUF4407 PF14362.6 EFO63748.1 - 0.05 13.0 7.4 0.13 11.6 7.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Lipoprotein_3 PF00938.17 EFO63748.1 - 0.055 13.6 0.1 0.2 11.9 0.1 2.0 1 0 0 1 1 1 0 Lipoprotein PMC2NT PF08066.12 EFO63748.1 - 0.06 14.0 0.8 0.23 12.2 0.3 2.2 2 1 0 2 2 2 0 PMC2NT (NUC016) domain DUF725 PF05267.12 EFO63748.1 - 0.1 12.6 1.2 11 6.0 0.0 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF725) OmpH PF03938.14 EFO63748.1 - 0.11 12.8 11.3 3.3 8.0 10.3 2.6 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) ApoO PF09769.9 EFO63748.1 - 0.14 12.1 3.4 12 5.9 0.4 3.1 2 1 2 4 4 4 0 Apolipoprotein O PMEI PF04043.15 EFO63748.1 - 0.24 11.8 1.4 29 5.0 0.9 2.4 1 1 1 2 2 2 0 Plant invertase/pectin methylesterase inhibitor Cor1 PF04803.12 EFO63748.1 - 0.26 11.5 9.0 0.12 12.6 5.2 2.3 1 1 1 2 2 2 0 Cor1/Xlr/Xmr conserved region Prominin PF05478.11 EFO63748.1 - 0.38 8.7 10.8 0.83 7.5 10.8 1.5 1 1 0 1 1 1 0 Prominin TINF2_N PF14973.6 EFO63748.1 - 0.39 11.1 6.4 0.2 12.0 1.8 2.6 1 1 2 3 3 3 0 TERF1-interacting nuclear factor 2 N-terminus FAM184 PF15665.5 EFO63748.1 - 0.57 9.9 18.2 0.13 12.0 7.9 2.5 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B DUF1451 PF07295.11 EFO63748.1 - 0.77 9.8 7.6 0.86 9.6 0.0 2.9 2 1 1 3 3 3 0 Zinc-ribbon containing domain PIN_8 PF18476.1 EFO63748.1 - 1 9.2 10.2 2.1 8.2 1.6 2.2 1 1 1 2 2 2 0 PIN like domain YlqD PF11068.8 EFO63748.1 - 1.3 9.4 12.7 18 5.7 0.0 2.9 1 1 2 3 3 3 0 YlqD protein Phage_Mu_Gam PF07352.12 EFO63748.1 - 1.8 8.4 9.9 2.5 8.0 0.1 3.2 1 1 3 4 4 4 0 Bacteriophage Mu Gam like protein Exonuc_VII_L PF02601.15 EFO63748.1 - 2.1 7.8 12.4 19 4.7 12.4 2.0 1 1 0 1 1 1 0 Exonuclease VII, large subunit Arc_PepC_II PF06847.11 EFO63748.1 - 2.2 8.9 5.3 27 5.4 0.1 3.0 1 1 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II KxDL PF10241.9 EFO63748.1 - 2.5 8.4 14.8 8.5 6.7 6.4 3.6 2 1 1 4 4 3 0 Uncharacterized conserved protein FAP206 PF12018.8 EFO63748.1 - 3.3 7.1 10.9 1.6 8.2 6.9 2.0 1 1 0 2 2 2 0 Domain of unknown function Baculo_p24 PF05073.12 EFO63748.1 - 3.5 7.4 9.2 16 5.3 7.3 2.1 1 1 1 2 2 2 0 Baculovirus P24 capsid protein GrpE PF01025.19 EFO63748.1 - 3.7 7.2 15.0 10 5.7 10.8 3.2 1 1 1 2 2 2 0 GrpE DUF2205 PF10224.9 EFO63748.1 - 5.6 7.0 9.2 11 6.1 0.1 3.9 2 1 1 4 4 4 0 Short coiled-coil protein Ank_2 PF12796.7 EFO63752.1 - 3e-18 66.2 0.0 2.7e-08 34.3 0.0 2.8 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63752.1 - 1.6e-08 34.9 0.0 0.0066 17.0 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63752.1 - 1.1e-06 28.5 0.0 0.082 13.5 0.0 4.6 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 EFO63752.1 - 1.5e-06 28.3 0.0 0.17 12.4 0.0 4.6 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 EFO63752.1 - 1.4e-05 25.3 0.0 0.031 14.6 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) AAA_13 PF13166.6 EFO63752.1 - 0.036 12.7 0.2 0.036 12.7 0.2 3.9 1 1 2 4 4 4 0 AAA domain PKcGMP_CC PF16808.5 EFO63752.1 - 2.5 8.0 17.5 1.1 9.2 0.7 6.0 5 0 0 5 5 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase V-SNARE_C PF12352.8 EFO63752.1 - 4.5 7.6 7.5 3 8.2 0.1 3.4 3 0 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus Csm1_N PF18504.1 EFO63752.1 - 6.2 7.2 53.8 3.1 8.2 0.2 9.1 5 3 4 9 9 9 0 Csm1 N-terminal domain Fez1 PF06818.15 EFO63752.1 - 6.7 7.1 53.8 0.13 12.7 1.7 4.9 2 1 3 5 5 5 0 Fez1 PFU PF09070.11 EFO63753.1 - 5.5e-18 65.3 0.1 1.1e-17 64.4 0.1 1.5 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40_like PF17005.5 EFO63753.1 - 0.028 13.8 0.3 0.065 12.6 0.2 1.6 1 1 0 1 1 1 0 WD40-like domain PQQ_3 PF13570.6 EFO63753.1 - 0.039 14.5 0.3 3.9 8.1 0.0 3.1 2 0 0 2 2 2 0 PQQ-like domain Ank_2 PF12796.7 EFO63755.1 - 3.8e-127 415.2 46.5 4.2e-17 62.5 0.1 14.8 4 4 10 15 15 15 13 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63755.1 - 2.4e-82 270.3 29.0 3.2e-07 30.8 0.0 17.8 16 3 0 17 17 17 14 Ankyrin repeats (many copies) Ank PF00023.30 EFO63755.1 - 4.1e-72 235.7 33.0 8.6e-05 22.8 0.0 22.6 19 4 3 22 22 22 15 Ankyrin repeat Ank_5 PF13857.6 EFO63755.1 - 1.4e-71 235.6 39.8 2.9e-05 24.3 0.4 20.8 4 3 19 23 23 23 17 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63755.1 - 4.4e-58 186.4 33.8 0.099 13.3 0.0 24.2 25 0 0 25 25 25 17 Ankyrin repeat LytR_cpsA_psr PF03816.14 EFO63755.1 - 0.0022 18.2 1.5 0.94 9.6 0.0 4.3 5 0 0 5 5 5 1 Cell envelope-related transcriptional attenuator domain Ank_2 PF12796.7 EFO63756.1 - 1.8e-37 127.8 5.1 4.5e-12 46.4 0.0 5.2 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63756.1 - 1e-20 73.8 3.6 1.1e-06 29.0 0.0 5.7 7 0 0 7 7 7 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO63756.1 - 2.4e-18 66.0 4.1 0.00058 20.1 0.0 7.3 4 1 3 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63756.1 - 2.5e-18 64.2 5.4 0.031 14.8 0.0 8.1 9 0 0 9 9 9 6 Ankyrin repeat Ank PF00023.30 EFO63756.1 - 5.8e-17 61.3 2.2 0.00047 20.5 0.0 6.5 7 0 0 7 7 7 3 Ankyrin repeat CwfJ_C_1 PF04677.15 EFO63757.1 - 2.2 8.2 5.4 0.74 9.7 0.1 2.8 3 1 1 4 4 4 0 Protein similar to CwfJ C-terminus 1 Methyltr_RsmB-F PF01189.17 EFO63758.1 - 3.5e-13 49.7 0.0 1.9e-12 47.2 0.0 2.0 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EFO63758.1 - 0.034 14.3 0.1 0.061 13.4 0.1 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase PalH PF08733.10 EFO63759.1 - 0.025 13.6 0.1 0.041 12.9 0.1 1.4 1 0 0 1 1 1 0 PalH/RIM21 5_nucleotid_C PF02872.18 EFO63759.1 - 0.055 13.7 0.1 0.75 10.0 0.0 2.7 4 0 0 4 4 4 0 5'-nucleotidase, C-terminal domain Fe_hyd_lg_C PF02906.14 EFO63761.1 - 7.4e-18 65.1 0.0 1.8e-17 63.8 0.0 1.6 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Ank_2 PF12796.7 EFO63762.1 - 7.6e-82 270.0 33.3 1.7e-11 44.6 0.1 10.9 3 3 9 12 12 12 11 Ankyrin repeats (3 copies) Ank PF00023.30 EFO63762.1 - 1.8e-39 132.5 22.7 0.019 15.4 0.0 16.5 14 2 1 15 15 15 12 Ankyrin repeat Ank_5 PF13857.6 EFO63762.1 - 3.2e-38 129.3 33.4 0.0029 17.9 0.1 17.8 7 3 13 20 20 20 14 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63762.1 - 1.1e-36 124.7 26.5 1.8e-05 25.2 0.2 13.9 10 3 6 16 16 16 12 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63762.1 - 2.3e-35 116.6 23.8 1 10.2 0.0 19.3 21 0 0 21 21 21 9 Ankyrin repeat DUF2195 PF09961.9 EFO63762.1 - 0.0035 17.3 4.3 0.085 12.8 0.1 4.0 4 0 0 4 4 4 1 Uncharacterized protein conserved in bacteria (DUF2195) DUF3447 PF11929.8 EFO63762.1 - 0.011 15.7 1.8 13 5.8 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF3447) CdAMP_rec PF06153.11 EFO63762.1 - 0.34 11.1 1.8 56 4.0 0.0 4.2 5 0 0 5 5 5 0 Cyclic-di-AMP receptor EamA PF00892.20 EFO63763.1 - 8.3e-08 32.5 1.7 8.3e-08 32.5 1.7 4.2 4 1 0 4 4 4 1 EamA-like transporter family CRT-like PF08627.10 EFO63763.1 - 0.48 9.3 18.6 0.016 14.2 8.8 2.3 1 1 1 2 2 2 0 CRT-like, chloroquine-resistance transporter-like CPP1-like PF11833.8 EFO63763.1 - 2.7 7.6 11.4 0.035 13.8 1.8 2.7 3 1 0 3 3 3 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Acetyltransf_7 PF13508.7 EFO63764.1 - 0.00054 20.3 0.1 0.0085 16.5 0.1 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFO63764.1 - 0.0045 17.2 0.1 0.044 14.0 0.1 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Abhydrolase_6 PF12697.7 EFO63765.1 - 5.8e-17 63.0 0.0 8.7e-17 62.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFO63765.1 - 6.2e-10 38.8 0.0 9.4e-10 38.2 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EFO63765.1 - 0.00073 19.5 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.13 EFO63765.1 - 0.0024 17.6 0.0 0.0034 17.1 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Chlorophyllase2 PF12740.7 EFO63765.1 - 0.006 15.5 0.0 0.0091 14.9 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_1 PF00561.20 EFO63765.1 - 0.0064 16.2 0.5 0.1 12.2 0.5 2.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Lipase_3 PF01764.25 EFO63765.1 - 0.0086 15.9 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.7 EFO63765.1 - 0.15 11.8 0.0 0.62 9.8 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase family Thioesterase PF00975.20 EFO63765.1 - 0.2 11.7 0.1 1.2 9.2 0.1 2.2 1 1 0 1 1 1 0 Thioesterase domain BAAT_C PF08840.11 EFO63765.1 - 0.21 11.5 0.0 0.42 10.5 0.0 1.5 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Pkinase PF00069.25 EFO63766.1 - 7.2e-28 97.7 0.0 7.2e-25 87.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63766.1 - 1.7e-13 50.5 0.0 6.8e-13 48.5 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase ATP_bind_3 PF01171.20 EFO63767.1 - 7.3e-10 38.9 0.1 1.3e-05 25.0 0.0 2.3 2 0 0 2 2 2 2 PP-loop family VSP PF03302.13 EFO63768.1 - 1.1e-46 159.5 183.3 1.8e-10 40.2 32.6 8.3 1 1 7 8 8 8 8 Giardia variant-specific surface protein DUF4690 PF15756.5 EFO63768.1 - 0.0001 22.8 0.2 0.0003 21.3 0.2 1.7 1 0 0 1 1 1 1 Small Novel Rich in Cartilage zf-CCHC_3 PF13917.6 EFO63768.1 - 0.49 10.4 0.1 0.49 10.4 0.1 4.4 4 0 0 4 4 4 0 Zinc knuckle Phage_holin_2_4 PF16082.5 EFO63768.1 - 0.92 9.3 2.7 0.94 9.3 0.4 2.2 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like Glyco_transf_41 PF13844.6 EFO63770.1 - 7.4e-58 196.1 0.1 7.9e-35 120.2 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 41 TPR_1 PF00515.28 EFO63770.1 - 6.1e-28 95.5 26.4 8.8e-07 28.5 1.1 9.2 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_2 PF07719.17 EFO63770.1 - 2.3e-24 83.5 18.5 0.00027 20.8 0.6 9.6 9 1 0 9 9 9 5 Tetratricopeptide repeat TPR_12 PF13424.6 EFO63770.1 - 4.3e-18 65.4 5.3 0.00069 19.9 0.1 7.6 7 1 0 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFO63770.1 - 3.6e-15 54.8 20.0 0.003 17.6 0.0 9.1 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFO63770.1 - 1.3e-10 40.8 13.1 4.6e-05 23.0 0.7 7.6 6 1 1 7 7 7 2 TPR repeat TPR_7 PF13176.6 EFO63770.1 - 4.4e-08 32.6 5.7 1.9 8.7 0.1 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFO63770.1 - 9.1e-08 32.3 0.2 0.33 11.9 0.0 6.7 5 3 4 9 9 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFO63770.1 - 2.3e-07 30.9 0.0 2e-06 27.9 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFO63770.1 - 7.2e-07 29.2 21.3 0.087 13.2 0.2 7.8 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFO63770.1 - 4.1e-06 27.3 0.0 2.3 8.9 0.1 4.9 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFO63770.1 - 1.8e-05 24.4 14.8 0.17 11.8 0.1 7.3 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFO63770.1 - 0.0003 21.2 6.3 0.7 10.5 0.1 5.6 6 0 0 6 6 5 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFO63770.1 - 0.00034 20.0 1.0 24 4.5 0.0 5.0 5 0 0 5 5 5 0 SHNi-TPR TPR_6 PF13174.6 EFO63770.1 - 0.0018 18.8 9.9 52 4.8 0.1 7.2 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EFO63770.1 - 0.0022 17.4 0.5 0.019 14.4 0.4 2.5 3 0 0 3 3 3 1 MalT-like TPR region ANAPC3 PF12895.7 EFO63770.1 - 0.0048 17.1 2.5 3.5 7.9 0.1 4.2 5 0 0 5 5 3 1 Anaphase-promoting complex, cyclosome, subunit 3 SNAP PF14938.6 EFO63770.1 - 0.018 14.5 0.6 0.79 9.1 0.1 3.2 3 1 0 3 3 3 0 Soluble NSF attachment protein, SNAP NARP1 PF12569.8 EFO63770.1 - 0.022 13.7 0.3 5.5 5.8 0.1 2.4 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 SLR1-BP PF07333.12 EFO63770.1 - 0.24 11.9 4.0 0.61 10.6 4.0 1.7 1 0 0 1 1 1 0 S locus-related glycoprotein 1 binding pollen coat protein (SLR1-BP) BPL_LplA_LipB PF03099.19 EFO63771.1 - 3.8e-05 23.6 0.0 7.2e-05 22.7 0.0 1.5 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family DEAD PF00270.29 EFO63772.1 - 1.1e-33 116.5 0.0 6.5e-33 113.9 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO63772.1 - 9.8e-27 93.5 0.0 3.9e-26 91.6 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFO63772.1 - 0.16 11.9 0.0 0.67 9.9 0.0 2.0 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit FlxA PF14282.6 EFO63773.1 - 0.025 14.5 1.4 0.079 12.9 1.4 1.8 1 0 0 1 1 1 0 FlxA-like protein DUF1664 PF07889.12 EFO63773.1 - 0.034 14.2 4.1 0.04 13.9 2.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Neural_ProG_Cyt PF06567.11 EFO63773.1 - 0.11 12.7 0.1 0.11 12.7 0.1 2.6 3 0 0 3 3 3 0 Neural chondroitin sulphate proteoglycan cytoplasmic domain ZapB PF06005.12 EFO63773.1 - 0.16 12.4 2.6 0.76 10.3 0.6 2.6 2 0 0 2 2 2 0 Cell division protein ZapB FliJ PF02050.16 EFO63773.1 - 0.19 12.0 2.8 0.45 10.7 2.8 1.6 1 0 0 1 1 1 0 Flagellar FliJ protein Pkinase PF00069.25 EFO63774.1 - 6.4e-34 117.5 1.8 6.4e-24 84.7 0.0 3.0 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63774.1 - 5.3e-23 81.6 0.0 3.5e-19 69.1 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFO63774.1 - 5.7e-05 22.6 0.0 0.00045 19.6 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Peptidase_S9 PF00326.21 EFO63775.1 - 3.1e-47 160.8 0.5 4.8e-47 160.2 0.5 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family PD40 PF07676.12 EFO63775.1 - 9.8e-05 22.2 1.3 0.15 12.1 0.2 3.4 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Hydrolase_4 PF12146.8 EFO63775.1 - 0.00078 18.8 0.0 0.052 12.8 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFO63775.1 - 0.0035 17.0 1.1 0.5 10.0 0.5 2.6 1 1 1 2 2 2 2 alpha/beta hydrolase fold Kelch_6 PF13964.6 EFO63775.1 - 0.051 13.9 0.3 3.8 8.0 0.0 3.6 4 0 0 4 4 4 0 Kelch motif DLH PF01738.18 EFO63775.1 - 0.18 11.3 0.0 0.5 9.9 0.0 1.6 1 1 0 1 1 1 0 Dienelactone hydrolase family MIF PF01187.18 EFO63776.1 - 1.9e-17 63.6 0.0 2e-17 63.5 0.0 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Tautomerase PF01361.21 EFO63776.1 - 0.0033 17.3 0.0 0.0051 16.7 0.0 1.3 1 0 0 1 1 1 1 Tautomerase enzyme Tautomerase_2 PF14552.6 EFO63776.1 - 0.0074 16.4 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Tautomerase enzyme TPR_1 PF00515.28 EFO63777.1 - 1.5e-14 53.1 10.6 0.00042 20.0 0.0 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFO63777.1 - 2.7e-13 48.9 15.9 0.00019 21.3 0.0 6.1 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFO63777.1 - 3.2e-13 49.8 16.1 0.0014 18.8 0.2 4.5 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFO63777.1 - 4.7e-05 23.3 11.2 13 6.3 0.1 6.0 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFO63777.1 - 0.00019 21.2 11.3 0.21 11.7 0.0 5.5 6 2 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFO63777.1 - 0.00096 19.8 6.4 0.25 12.2 0.0 5.2 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EFO63777.1 - 0.0044 16.4 3.0 1.2 8.5 0.2 3.0 3 0 0 3 3 3 2 MalT-like TPR region TPR_10 PF13374.6 EFO63777.1 - 0.014 15.3 8.9 0.092 12.7 0.2 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFO63777.1 - 0.066 13.4 2.9 29 4.9 0.2 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Caskin-tail PF16632.5 EFO63777.1 - 0.13 12.7 1.5 2.1 8.8 0.0 2.8 3 0 0 3 3 3 0 C-terminal region of Caskin GCV_T_C PF08669.11 EFO63777.1 - 0.18 11.8 0.0 2.5 8.1 0.0 2.3 2 0 0 2 2 2 0 Glycine cleavage T-protein C-terminal barrel domain Fis1_TPR_C PF14853.6 EFO63777.1 - 0.28 11.3 1.8 1.2 9.3 0.1 2.8 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_11 PF13414.6 EFO63777.1 - 0.41 10.4 5.2 2.2 8.0 0.2 4.0 4 0 0 4 4 4 0 TPR repeat TPR_16 PF13432.6 EFO63777.1 - 0.57 10.9 14.0 2.9 8.6 0.0 4.6 4 1 2 6 6 6 0 Tetratricopeptide repeat Pkinase PF00069.25 EFO63780.1 - 3.1e-19 69.4 0.0 6.3e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63780.1 - 1.4e-16 60.5 0.0 2.2e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO63780.1 - 3.6e-07 30.7 0.2 1.7e-06 28.5 0.1 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63780.1 - 6.7e-07 29.5 0.1 0.0003 21.0 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63780.1 - 0.00018 22.0 0.2 0.0012 19.3 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EFO63780.1 - 0.00082 19.7 0.3 0.0098 16.3 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 EFO63780.1 - 0.0068 16.8 2.7 0.26 12.0 0.0 4.0 5 0 0 5 5 5 1 Ankyrin repeat Ank_2 PF12796.7 EFO63781.1 - 8.9e-74 244.1 14.2 1.1e-12 48.3 0.0 11.3 1 1 11 12 12 12 12 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63781.1 - 7.6e-44 147.2 12.4 2.6e-06 27.6 0.0 13.4 11 2 3 14 14 14 9 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63781.1 - 1.7e-43 146.4 14.5 0.004 17.7 0.1 16.1 12 5 5 17 17 17 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63781.1 - 6.1e-34 112.2 16.1 0.41 11.4 0.0 19.4 19 1 1 20 20 20 6 Ankyrin repeat Ank PF00023.30 EFO63781.1 - 3.2e-30 103.2 15.9 0.011 16.2 0.0 18.1 18 2 2 20 20 20 7 Ankyrin repeat DUF3447 PF11929.8 EFO63781.1 - 0.0028 17.6 0.0 2.1 8.4 0.0 3.7 2 1 2 4 4 4 1 Domain of unknown function (DUF3447) HEXIM PF15313.6 EFO63782.1 - 0.013 15.7 1.0 0.013 15.7 1.0 2.8 2 0 0 2 2 2 0 Hexamethylene bis-acetamide-inducible protein DUF641 PF04859.12 EFO63782.1 - 0.07 13.5 1.8 0.2 12.0 1.8 1.8 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) DHR10 PF18595.1 EFO63782.1 - 0.071 13.2 2.1 0.18 11.8 2.1 1.7 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain U3snoRNP10 PF12397.8 EFO63782.1 - 0.09 13.1 0.7 4 7.8 0.1 3.0 2 0 0 2 2 2 0 U3 small nucleolar RNA-associated protein 10 ACDC PF14733.6 EFO63782.1 - 0.14 12.5 4.2 0.63 10.4 0.2 3.3 4 0 0 4 4 4 0 AP2-coincident C-terminal Spc7 PF08317.11 EFO63782.1 - 0.16 10.8 15.1 0.1 11.5 2.6 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein APG6_N PF17675.1 EFO63783.1 - 0.0014 19.2 15.1 0.0014 19.2 15.1 3.6 2 1 1 3 3 3 1 Apg6 coiled-coil region KASH_CCD PF14662.6 EFO63783.1 - 0.0035 17.2 22.9 0.0059 16.4 9.2 3.7 1 1 1 4 4 4 1 Coiled-coil region of CCDC155 or KASH HALZ PF02183.18 EFO63783.1 - 0.0063 16.7 1.0 0.0063 16.7 1.0 3.5 5 0 0 5 5 2 1 Homeobox associated leucine zipper LOB PF03195.14 EFO63783.1 - 0.033 14.7 0.0 0.11 13.0 0.0 1.9 1 0 0 1 1 1 0 Lateral organ boundaries (LOB) domain SQHop_cyclase_N PF13249.6 EFO63783.1 - 0.046 12.8 0.1 0.07 12.2 0.1 1.3 1 0 0 1 1 1 0 Squalene-hopene cyclase N-terminal domain TolA_bind_tri PF16331.5 EFO63783.1 - 0.054 13.6 0.2 0.054 13.6 0.2 3.9 3 1 1 4 4 4 0 TolA binding protein trimerisation AAA_13 PF13166.6 EFO63783.1 - 0.067 11.8 11.8 0.32 9.6 11.8 1.7 1 1 1 2 2 2 0 AAA domain FH2 PF02181.23 EFO63783.1 - 0.14 11.2 7.7 0.041 13.0 2.0 2.3 2 1 1 3 3 3 0 Formin Homology 2 Domain CobD_Cbib PF03186.13 EFO63783.1 - 0.14 11.3 0.9 0.21 10.8 0.9 1.3 1 0 0 1 1 1 0 CobD/Cbib protein Med9 PF07544.13 EFO63783.1 - 0.17 12.0 8.9 0.33 11.1 0.2 4.1 3 1 1 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 bZIP_1 PF00170.21 EFO63783.1 - 0.2 11.8 10.1 0.24 11.5 0.6 3.9 5 0 0 5 5 3 0 bZIP transcription factor MPS2 PF17060.5 EFO63783.1 - 0.36 10.1 4.0 0.12 11.6 0.7 1.9 2 0 0 2 2 2 0 Monopolar spindle protein 2 Spectrin PF00435.21 EFO63783.1 - 0.43 11.1 16.8 2.6 8.6 0.1 3.9 2 1 1 4 4 4 0 Spectrin repeat BRE1 PF08647.11 EFO63783.1 - 0.5 10.5 12.1 0.27 11.4 7.8 2.5 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase DUF3819 PF12842.7 EFO63783.1 - 0.55 10.2 12.0 1.1 9.2 3.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3819) TMF_TATA_bd PF12325.8 EFO63783.1 - 0.58 10.4 20.5 0.15 12.2 8.6 3.5 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding CENP-Q PF13094.6 EFO63783.1 - 0.84 9.8 18.2 1.6 8.9 8.9 3.2 1 1 2 4 4 4 0 CENP-Q, a CENPA-CAD centromere complex subunit SKA1 PF07160.12 EFO63783.1 - 0.86 9.4 13.2 1.1 9.0 2.6 3.1 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 1 DUF3450 PF11932.8 EFO63783.1 - 1 8.6 16.3 0.08 12.2 4.9 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) Ly49 PF08391.10 EFO63783.1 - 1.4 9.3 7.0 1.5 9.2 3.6 2.5 2 1 1 3 3 3 0 Ly49-like protein, N-terminal region Mod_r PF07200.13 EFO63783.1 - 1.4 9.0 17.9 2.5 8.2 12.6 3.0 1 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF1664 PF07889.12 EFO63783.1 - 1.4 9.0 11.8 9.5 6.3 2.5 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Macoilin PF09726.9 EFO63783.1 - 1.5 7.3 9.8 1.1 7.7 8.1 1.2 1 1 0 1 1 1 0 Macoilin family DUF3037 PF11236.8 EFO63783.1 - 2 8.9 5.1 15 6.0 5.1 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3037) Syntaxin-6_N PF09177.11 EFO63783.1 - 2.8 8.6 9.1 25 5.5 4.7 3.6 2 1 0 2 2 2 0 Syntaxin 6, N-terminal GrpE PF01025.19 EFO63783.1 - 3.2 7.4 11.5 1.8 8.2 1.6 3.3 2 1 1 3 3 3 0 GrpE DUF4200 PF13863.6 EFO63783.1 - 3.2 8.2 13.9 0.22 11.9 3.7 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) Bcr-Abl_Oligo PF09036.10 EFO63783.1 - 3.4 7.7 5.4 7.8 6.6 0.2 3.4 3 0 0 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain ATG16 PF08614.11 EFO63783.1 - 4.7 7.4 19.7 20 5.3 18.6 2.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) V_ATPase_I PF01496.19 EFO63783.1 - 5.3 4.8 9.4 0.78 7.6 5.0 1.6 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Cnn_1N PF07989.11 EFO63783.1 - 5.4 7.2 17.6 0.72 10.0 1.1 4.6 3 2 2 5 5 5 0 Centrosomin N-terminal motif 1 DUF615 PF04751.14 EFO63783.1 - 8.3 6.4 12.2 3.8 7.5 0.3 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF615) EF1G PF00647.19 EFO63784.1 - 1e-24 86.6 0.5 2e-24 85.7 0.5 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 EFO63784.1 - 3.1e-06 27.3 0.0 7.7e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFO63784.1 - 0.00036 20.3 0.4 0.00074 19.3 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFO63784.1 - 0.00047 20.1 0.0 0.0012 18.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFO63784.1 - 0.0092 16.2 0.0 0.025 14.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain UPF0524 PF15823.5 EFO63784.1 - 0.082 12.3 0.1 0.17 11.3 0.1 1.4 1 0 0 1 1 1 0 UPF0524 of C3orf70 PALP PF00291.25 EFO63786.1 - 7.6e-66 222.5 0.4 9.3e-65 218.9 0.7 2.0 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme aGPT-Pplase2 PF18724.1 EFO63786.1 - 0.027 14.3 0.2 0.087 12.6 0.2 1.8 1 1 0 1 1 1 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 2 aGPT-Pplase3 PF18746.1 EFO63786.1 - 0.11 11.9 0.4 0.43 9.9 0.0 2.0 2 0 0 2 2 2 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3 Acyltransferase PF01553.21 EFO63787.1 - 8.8e-12 44.8 0.0 1.7e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Ank_2 PF12796.7 EFO63788.1 - 1.2e-57 192.4 5.1 4.3e-11 43.3 0.1 8.6 2 1 6 8 8 8 8 Ankyrin repeats (3 copies) Ank PF00023.30 EFO63788.1 - 5.7e-26 89.8 13.6 0.00071 19.9 0.0 11.4 12 1 0 12 12 12 7 Ankyrin repeat Ank_4 PF13637.6 EFO63788.1 - 3.1e-25 88.2 6.6 4.9e-05 23.8 0.0 10.2 9 3 4 13 13 13 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO63788.1 - 2e-24 85.3 15.0 1.5e-05 25.1 0.1 11.3 8 3 6 14 14 14 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63788.1 - 2.8e-22 76.4 14.1 0.5 11.1 0.0 14.2 15 0 0 15 15 15 5 Ankyrin repeat ATP_bind_1 PF03029.17 EFO63788.1 - 0.014 15.2 0.1 0.055 13.2 0.0 1.9 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein adh_short PF00106.25 EFO63789.1 - 1.4e-16 60.6 0.0 1.8e-16 60.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFO63789.1 - 5.9e-08 32.8 0.0 8e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EFO63789.1 - 2.7e-06 27.1 0.0 3.5e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF4235 PF14019.6 EFO63789.1 - 0.13 12.4 0.1 0.25 11.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4235) AAA_6 PF12774.7 EFO63790.1 - 2.6e-154 513.1 0.0 1.4e-153 510.6 0.0 2.3 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFO63790.1 - 1.2e-100 337.4 0.7 1.2e-100 337.4 0.7 2.4 2 1 0 2 2 1 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 EFO63790.1 - 3.5e-90 301.8 0.0 2e-89 299.4 0.0 2.3 1 1 0 1 1 1 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 EFO63790.1 - 3e-83 279.6 0.0 9.7e-82 274.6 0.0 3.1 3 0 0 3 3 3 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 EFO63790.1 - 2.1e-74 249.4 0.3 2.1e-74 249.4 0.3 3.2 3 0 0 3 3 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 EFO63790.1 - 4.7e-62 208.7 0.1 5e-59 198.8 0.0 3.5 3 0 0 3 3 3 1 P-loop containing dynein motor region MT PF12777.7 EFO63790.1 - 5.9e-59 199.8 13.8 1.2e-58 198.8 13.8 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 EFO63790.1 - 2.8e-37 127.4 2.5 1.4e-35 122.0 0.1 3.4 3 0 0 3 3 2 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 EFO63790.1 - 5.5e-37 127.1 0.1 1.4e-36 125.8 0.1 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 EFO63790.1 - 5.9e-15 55.3 0.3 3.1e-14 53.0 0.1 2.4 2 0 0 2 2 1 1 AAA+ lid domain AAA_5 PF07728.14 EFO63790.1 - 3.6e-13 49.7 0.1 0.014 15.4 0.0 5.9 5 1 0 5 5 4 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 EFO63790.1 - 2.1e-12 47.2 0.3 1.1e-09 38.5 0.3 3.1 1 1 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA PF00004.29 EFO63790.1 - 7.4e-09 36.1 0.1 0.038 14.4 0.0 4.3 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFO63790.1 - 3.5e-07 30.6 0.4 0.013 15.8 0.1 5.3 4 1 0 4 4 4 1 AAA domain AAA_16 PF13191.6 EFO63790.1 - 1e-06 29.2 0.4 0.0021 18.5 0.0 4.6 3 1 1 4 4 4 1 AAA ATPase domain AAA_14 PF13173.6 EFO63790.1 - 2.2e-05 24.5 0.1 0.0016 18.5 0.0 3.6 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 EFO63790.1 - 3.1e-05 23.2 0.0 3.1e-05 23.2 0.0 2.8 4 0 0 4 4 3 1 Type II/IV secretion system protein AAA_18 PF13238.6 EFO63790.1 - 0.00037 21.0 0.0 0.47 11.0 0.0 4.1 3 0 0 3 3 3 1 AAA domain Sigma54_activat PF00158.26 EFO63790.1 - 0.001 18.8 0.0 0.0054 16.4 0.0 2.2 2 0 0 2 2 2 1 Sigma-54 interaction domain NACHT PF05729.12 EFO63790.1 - 0.0046 16.9 0.0 0.12 12.3 0.0 2.8 2 0 0 2 2 2 1 NACHT domain FtsK_SpoIIIE PF01580.18 EFO63790.1 - 0.0059 16.0 0.2 0.44 9.8 0.0 2.8 2 0 0 2 2 2 1 FtsK/SpoIIIE family RNA_helicase PF00910.22 EFO63790.1 - 0.0078 16.6 0.0 8.1 6.9 0.0 3.4 3 0 0 3 3 3 0 RNA helicase AAA_30 PF13604.6 EFO63790.1 - 0.016 14.9 2.6 9.3 5.9 0.0 3.8 4 0 0 4 4 4 0 AAA domain DUF2075 PF09848.9 EFO63790.1 - 0.018 14.3 0.3 0.058 12.6 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 EFO63790.1 - 0.027 14.4 0.2 0.24 11.3 0.0 2.8 2 0 0 2 2 1 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 EFO63790.1 - 0.081 12.7 1.0 0.24 11.2 0.1 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_lid_7 PF17867.1 EFO63790.1 - 0.088 13.0 0.0 0.37 11.0 0.0 2.2 1 0 0 1 1 1 0 Midasin AAA lid domain AAA_19 PF13245.6 EFO63790.1 - 0.12 12.7 0.1 5.5 7.3 0.0 2.9 2 0 0 2 2 2 0 AAA domain Ins134_P3_kin_N PF17927.1 EFO63791.1 - 0.14 12.5 0.0 0.42 11.0 0.0 1.7 1 0 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain Kinesin PF00225.23 EFO63792.1 - 9.9e-07 28.0 0.0 9.9e-07 28.0 0.0 2.7 4 0 0 4 4 4 1 Kinesin motor domain HALZ PF02183.18 EFO63792.1 - 0.0036 17.5 0.5 0.0036 17.5 0.5 3.6 3 0 0 3 3 3 1 Homeobox associated leucine zipper Microtub_bd PF16796.5 EFO63792.1 - 0.0053 16.7 0.0 0.014 15.4 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Golgin_A5 PF09787.9 EFO63792.1 - 0.025 14.1 40.5 0.48 9.8 9.0 3.2 1 1 0 2 2 2 0 Golgin subfamily A member 5 IL2 PF00715.17 EFO63792.1 - 0.036 14.0 1.5 2.3 8.2 0.2 2.7 2 1 0 2 2 2 0 Interleukin 2 ACR_tran PF00873.19 EFO63792.1 - 0.17 9.5 2.3 0.26 8.9 2.3 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Scaffolding_pro PF11418.8 EFO63792.1 - 0.23 12.0 2.6 4.3 7.9 0.1 3.6 2 1 1 3 3 3 0 Phi29 scaffolding protein DUF812 PF05667.11 EFO63792.1 - 0.24 10.2 30.9 0.54 9.1 5.8 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF812) GAS PF13851.6 EFO63792.1 - 0.64 9.3 30.0 0.76 9.1 8.6 2.6 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding YabA PF06156.13 EFO63792.1 - 3.4 8.4 25.1 0.069 13.8 2.7 4.4 2 1 2 4 4 4 0 Initiation control protein YabA DUF4472 PF14739.6 EFO63792.1 - 4.3 8.1 29.8 0.61 10.8 4.4 3.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4472) Fib_alpha PF08702.10 EFO63792.1 - 4.4 7.5 24.3 0.8 9.9 1.8 3.8 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.9 EFO63792.1 - 5.6 7.3 19.6 2.5 8.4 1.9 5.0 4 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Mod_r PF07200.13 EFO63792.1 - 6.4 6.9 31.4 0.21 11.7 5.8 4.2 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Prefoldin PF02996.17 EFO63792.1 - 6.5 6.7 15.3 1.1 9.2 1.7 4.9 4 2 1 5 5 5 0 Prefoldin subunit Laminin_II PF06009.12 EFO63792.1 - 7.2 6.6 19.2 0.039 14.0 1.0 3.9 3 1 1 4 4 4 0 Laminin Domain II Phage_GP20 PF06810.11 EFO63792.1 - 8.9 6.1 26.8 2.7 7.8 0.2 4.9 1 1 4 5 5 5 0 Phage minor structural protein GP20 Ribosomal_L26 PF16906.5 EFO63794.1 - 1.1e-27 96.2 0.7 1.4e-27 95.9 0.7 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal HAS-barrel PF09378.10 EFO63794.1 - 0.0038 17.3 0.0 0.0052 16.9 0.0 1.3 1 0 0 1 1 1 1 HAS barrel domain DUF4602 PF15375.6 EFO63796.1 - 3.4 8.0 12.3 1.5 9.1 9.1 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4602) COXG PF06240.13 EFO63797.1 - 0.0012 18.6 0.1 0.0026 17.5 0.1 1.6 1 1 0 1 1 1 1 Carbon monoxide dehydrogenase subunit G (CoxG) DUF2460 PF09343.10 EFO63797.1 - 0.017 14.6 0.1 0.025 14.1 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 2217 (DUF2460) PNP_UDP_1 PF01048.20 EFO63798.1 - 8.8e-45 152.8 0.0 1e-44 152.5 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Photo_RC PF00124.19 EFO63798.1 - 0.00023 20.5 0.1 0.00034 19.9 0.1 1.1 1 0 0 1 1 1 1 Photosynthetic reaction centre protein Ras PF00071.22 EFO63799.1 - 3.1e-31 108.2 0.0 3.7e-31 107.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFO63799.1 - 6e-23 81.3 0.0 8.1e-23 80.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFO63799.1 - 6.7e-07 28.9 0.0 8e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFO63799.1 - 4.3e-06 26.3 0.0 5.8e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFO63799.1 - 0.0015 18.1 0.0 0.056 13.0 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Dfp1_Him1_M PF08630.10 EFO63799.1 - 0.088 13.0 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Dfp1/Him1, central region AAA_22 PF13401.6 EFO63799.1 - 0.17 12.2 0.0 0.51 10.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain EF-hand_1 PF00036.32 EFO63800.1 - 0.02 14.4 0.1 0.086 12.4 0.1 2.2 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 EFO63800.1 - 0.054 14.0 0.7 0.14 12.6 0.0 2.0 2 1 0 2 2 2 0 EF-hand domain pair WD40 PF00400.32 EFO63802.1 - 3.5e-13 49.8 4.2 3.5e-06 27.6 0.0 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO63802.1 - 6.2e-06 26.4 0.0 0.1 12.9 0.0 3.7 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain CSTF1_dimer PF16699.5 EFO63802.1 - 0.037 13.8 0.1 0.071 12.9 0.1 1.5 1 0 0 1 1 1 0 Cleavage stimulation factor subunit 1, dimerisation domain Ala_racemase_N PF01168.20 EFO63803.1 - 2.8e-26 92.5 0.1 3.2e-26 92.3 0.1 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain DUF2655 PF10848.8 EFO63804.1 - 0.047 14.0 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2655) Sec34 PF04136.15 EFO63804.1 - 0.091 12.6 0.9 12 5.7 0.1 2.2 2 0 0 2 2 2 0 Sec34-like family Sas10_Utp3 PF04000.15 EFO63805.1 - 2.8e-10 40.7 0.0 2.8e-10 40.7 0.0 3.0 4 0 0 4 4 4 1 Sas10/Utp3/C1D family PurS PF02700.14 EFO63805.1 - 0.0039 17.3 0.0 0.012 15.8 0.0 1.8 1 0 0 1 1 1 1 Phosphoribosylformylglycinamidine (FGAM) synthase DUF1664 PF07889.12 EFO63805.1 - 0.15 12.1 2.2 4.8 7.2 0.5 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Ank_2 PF12796.7 EFO63806.1 - 1.2e-14 54.7 2.9 2.4e-14 53.7 0.1 2.7 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO63806.1 - 1.8e-12 47.2 0.0 3.6e-12 46.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 EFO63806.1 - 1.1e-08 35.4 0.6 0.0062 17.1 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO63806.1 - 1.9e-08 33.9 0.0 3.8e-08 32.9 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Ank_3 PF13606.6 EFO63806.1 - 2.6e-06 27.3 2.2 0.25 12.0 0.1 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EFO63806.1 - 8.3e-06 26.0 5.6 0.00043 20.5 0.2 3.9 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO63806.1 - 1.3e-05 25.4 3.4 0.029 14.8 0.1 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.7 EFO63807.1 - 3.4e-73 242.3 21.1 3.5e-17 62.8 0.6 6.6 1 1 6 8 8 8 8 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO63807.1 - 9.4e-38 130.1 0.0 2.2e-37 128.9 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Ank PF00023.30 EFO63807.1 - 1.8e-37 126.1 7.0 0.001 19.4 0.1 12.4 11 1 2 13 13 13 10 Ankyrin repeat Ank_5 PF13857.6 EFO63807.1 - 5.5e-36 122.1 19.0 0.00078 19.7 0.1 10.6 3 2 8 11 11 11 9 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63807.1 - 1e-32 112.1 12.3 3.2e-09 37.1 0.1 8.4 8 1 0 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63807.1 - 9.4e-28 93.2 11.1 0.038 14.5 0.1 12.1 12 1 1 13 13 13 8 Ankyrin repeat Pkinase_Tyr PF07714.17 EFO63807.1 - 6.7e-23 81.3 0.0 4.9e-22 78.5 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO63807.1 - 1.1e-08 34.7 0.0 3.3e-08 33.2 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Myticin-prepro PF10690.9 EFO63807.1 - 0.36 11.1 2.6 0.42 10.9 0.8 2.1 1 1 0 1 1 1 0 Myticin pre-proprotein from the mussel Ank_2 PF12796.7 EFO63808.1 - 9.7e-42 141.5 2.4 1.1e-12 48.4 0.1 3.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63808.1 - 1.9e-15 56.7 4.7 0.0027 18.0 0.0 5.4 1 1 4 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO63808.1 - 1.3e-13 50.7 0.0 0.0011 19.3 0.1 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EFO63808.1 - 1.7e-12 46.3 0.3 0.033 14.7 0.2 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EFO63808.1 - 1.9e-09 37.9 0.1 0.054 14.1 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO63808.1 - 6.5e-09 35.5 0.0 3.6e-08 33.1 0.0 2.1 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63808.1 - 6.9e-06 25.5 0.0 1.7e-05 24.3 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase FhuF PF06276.12 EFO63808.1 - 0.044 14.2 0.1 5.8 7.3 0.0 2.5 2 0 0 2 2 2 0 Ferric iron reductase FhuF-like transporter JAB PF01398.21 EFO63809.1 - 8.1e-28 96.8 0.3 1.2e-27 96.2 0.3 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EFO63809.1 - 0.00036 20.3 0.0 0.00059 19.6 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 EFO63809.1 - 0.034 14.2 0.0 0.053 13.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) zf-C3Hc3H PF13891.6 EFO63810.1 - 0.002 18.5 0.4 0.002 18.5 0.4 1.8 2 1 0 2 2 2 1 Potential DNA-binding domain RPAP2_Rtr1 PF04181.13 EFO63810.1 - 0.073 13.4 0.0 2.4 8.6 0.0 2.4 1 1 1 2 2 2 0 Rtr1/RPAP2 family YchF-GTPase_C PF06071.13 EFO63811.1 - 6.6e-35 119.2 0.0 1.3e-34 118.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF933) Ank_2 PF12796.7 EFO63812.1 - 2.6e-23 82.4 1.1 1e-10 42.1 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO63812.1 - 1.2e-15 56.0 0.1 0.094 13.3 0.0 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EFO63812.1 - 3.3e-13 49.4 0.1 0.44 11.1 0.0 5.4 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 EFO63812.1 - 1.1e-11 44.7 0.1 0.0012 19.2 0.0 4.9 2 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63812.1 - 1.7e-10 41.2 0.0 0.0093 16.5 0.0 4.0 3 1 1 4 4 4 3 Ankyrin repeats (many copies) zf-C2H2_6 PF13912.6 EFO63813.1 - 0.15 12.1 0.3 0.15 12.1 0.3 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger RVT_1 PF00078.27 EFO63814.1 - 5.4e-13 49.0 0.0 8.8e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 EFO63815.1 - 0.011 15.3 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Brix PF04427.18 EFO63816.1 - 3.3e-32 112.2 0.0 4.2e-32 111.8 0.0 1.1 1 0 0 1 1 1 1 Brix domain Prok_Ub PF14454.6 EFO63816.1 - 0.0023 17.6 0.4 0.77 9.5 0.0 3.1 2 1 1 3 3 3 2 Prokaryotic Ubiquitin PA28_beta PF02252.18 EFO63817.1 - 6.7e-11 42.1 1.3 1.3e-10 41.2 0.4 1.8 2 1 0 2 2 2 1 Proteasome activator pa28 beta subunit VSP PF03302.13 EFO63818.1 - 2.9e-09 36.3 93.9 0.00025 20.0 29.9 4.0 1 1 1 2 2 2 2 Giardia variant-specific surface protein cEGF PF12662.7 EFO63818.1 - 0.0019 18.1 0.9 0.0019 18.1 0.9 8.1 9 1 0 9 9 9 2 Complement Clr-like EGF-like Ras PF00071.22 EFO63819.1 - 3.5e-59 199.0 0.6 4.3e-59 198.7 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFO63819.1 - 1e-31 109.6 0.1 2e-31 108.7 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFO63819.1 - 6.5e-11 42.0 0.0 8.9e-11 41.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFO63819.1 - 8.2e-05 22.7 0.0 0.00014 21.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFO63819.1 - 0.039 13.5 0.1 0.55 9.8 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B Cellulase PF00150.18 EFO63820.1 - 1.1e-09 38.1 0.0 1e-08 35.0 0.0 2.0 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) SMC_N PF02463.19 EFO63822.1 - 2.1e-23 82.9 0.0 1.5e-11 44.1 0.0 2.5 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFO63822.1 - 2.5e-17 64.0 0.0 2.5e-17 64.0 0.0 4.6 3 1 1 4 4 3 1 AAA domain AAA_21 PF13304.6 EFO63822.1 - 7.9e-14 52.2 0.0 1.8e-06 28.0 0.1 2.8 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFO63822.1 - 3.2e-11 43.5 33.3 6.8e-09 35.9 0.0 4.7 3 1 1 4 4 4 2 AAA ATPase domain AAA_29 PF13555.6 EFO63822.1 - 4e-07 29.7 0.0 9.5e-07 28.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFO63822.1 - 1.3e-05 25.6 0.1 0.00039 20.9 0.0 3.0 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 EFO63822.1 - 1.6e-05 25.4 0.8 0.0012 19.4 0.0 3.4 3 1 0 3 3 3 1 ABC transporter AAA_27 PF13514.6 EFO63822.1 - 0.00068 19.3 0.0 0.0022 17.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFO63822.1 - 0.0012 19.1 6.1 0.035 14.4 0.0 4.1 3 1 1 4 4 4 1 AAA domain AAA_33 PF13671.6 EFO63822.1 - 0.0091 16.2 0.2 0.44 10.7 0.0 3.2 3 0 0 3 3 3 1 AAA domain SbcCD_C PF13558.6 EFO63822.1 - 0.0093 16.2 0.0 0.026 14.7 0.0 1.8 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 EFO63822.1 - 0.024 14.5 0.3 0.18 11.7 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase NACHT PF05729.12 EFO63822.1 - 0.031 14.2 0.1 0.16 11.9 0.0 2.3 2 0 0 2 2 2 0 NACHT domain GTP_EFTU PF00009.27 EFO63822.1 - 0.04 13.5 0.0 0.17 11.4 0.0 2.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain cobW PF02492.19 EFO63822.1 - 0.098 12.2 1.3 0.16 11.5 0.0 2.1 2 0 0 2 2 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EFO63822.1 - 0.12 12.1 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Shugoshin_N PF07558.11 EFO63823.1 - 0.015 15.2 9.6 0.044 13.7 0.9 3.4 4 0 0 4 4 4 0 Shugoshin N-terminal coiled-coil region Cnn_1N PF07989.11 EFO63823.1 - 0.069 13.3 11.9 7.4 6.8 0.0 4.6 3 1 0 3 3 3 0 Centrosomin N-terminal motif 1 TSC22 PF01166.18 EFO63823.1 - 0.12 12.7 14.2 5.5 7.4 1.0 4.9 4 1 0 4 4 4 0 TSC-22/dip/bun family Alph_Pro_TM PF09608.10 EFO63823.1 - 0.18 11.6 1.2 1.4 8.7 0.0 2.4 3 0 0 3 3 3 0 Putative transmembrane protein (Alph_Pro_TM) Osmo_CC PF08946.10 EFO63823.1 - 0.48 10.7 2.9 18 5.7 0.8 3.8 3 0 0 3 3 3 0 Osmosensory transporter coiled coil Mito_fiss_reg PF05308.11 EFO63823.1 - 0.64 10.1 15.3 0.73 9.9 1.1 2.8 3 1 0 3 3 3 0 Mitochondrial fission regulator TPR_MLP1_2 PF07926.12 EFO63823.1 - 0.86 9.7 26.5 0.27 11.3 2.5 4.3 3 1 0 4 4 4 0 TPR/MLP1/MLP2-like protein FAM76 PF16046.5 EFO63823.1 - 1.8 7.9 7.0 0.42 9.9 3.7 1.7 2 0 0 2 2 2 0 FAM76 protein ZapB PF06005.12 EFO63823.1 - 5.3 7.5 20.3 6 7.4 1.1 4.6 3 1 2 5 5 5 0 Cell division protein ZapB BicD PF09730.9 EFO63825.1 - 0.00075 18.1 11.9 0.0012 17.4 11.9 1.2 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D KASH_CCD PF14662.6 EFO63825.1 - 0.084 12.7 13.8 0.61 9.9 13.7 2.2 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH FAM76 PF16046.5 EFO63825.1 - 0.11 11.8 2.1 0.19 11.1 2.1 1.4 1 0 0 1 1 1 0 FAM76 protein Occludin_ELL PF07303.13 EFO63825.1 - 0.12 13.1 10.0 0.054 14.2 6.7 2.0 2 0 0 2 2 2 0 Occludin homology domain YabA PF06156.13 EFO63825.1 - 2.4 8.8 11.0 1.2 9.8 7.2 2.5 2 1 0 2 2 2 0 Initiation control protein YabA Sec2p PF06428.11 EFO63825.1 - 2.5 8.2 12.8 1.7 8.7 3.4 2.7 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p HALZ PF02183.18 EFO63825.1 - 3.4 8.0 13.4 0.58 10.4 2.9 3.3 2 1 1 3 3 3 0 Homeobox associated leucine zipper Prp19 PF08606.11 EFO63825.1 - 4.4 7.4 11.0 18 5.4 0.6 3.6 3 0 0 3 3 3 0 Prp19/Pso4-like Ank_2 PF12796.7 EFO63826.1 - 4.2e-61 203.5 1.4 2e-16 60.4 0.0 6.0 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63826.1 - 2.3e-40 136.4 3.7 9.8e-11 42.0 0.1 8.4 7 3 2 9 9 9 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO63826.1 - 1.4e-36 123.3 0.3 6.2e-05 23.3 0.0 9.3 9 1 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 EFO63826.1 - 3.2e-31 107.0 6.9 7.4e-06 26.2 0.0 8.1 4 2 5 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63826.1 - 2.2e-29 98.2 0.6 8.6e-05 22.7 0.0 8.9 8 2 1 9 9 9 6 Ankyrin repeat DUF2125 PF09898.9 EFO63826.1 - 0.0041 16.8 1.5 0.0041 16.8 1.5 1.8 2 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2125) Ank_2 PF12796.7 EFO63827.1 - 4.5e-18 65.6 0.3 5.6e-10 39.7 0.0 3.2 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO63827.1 - 5.9e-13 47.7 0.0 0.096 13.3 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 EFO63827.1 - 1.5e-11 44.1 0.0 4.7 7.8 0.0 5.4 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 EFO63827.1 - 2.1e-11 43.8 0.1 0.15 12.4 0.0 5.2 3 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63827.1 - 4.1e-09 36.8 0.0 0.14 12.8 0.0 4.5 2 2 2 4 4 4 4 Ankyrin repeats (many copies) YchF-GTPase_C PF06071.13 EFO63828.1 - 1.1e-32 112.0 0.1 2.1e-32 111.1 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF933) Stomoxyn PF11585.8 EFO63828.1 - 0.028 14.4 0.5 0.059 13.4 0.5 1.5 1 0 0 1 1 1 0 Insect antimicrobial peptide, stomoxyn GTP_EFTU PF00009.27 EFO63829.1 - 6.2e-46 156.4 0.0 1.1e-45 155.6 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EFO63829.1 - 0.0024 17.9 0.0 0.0052 16.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EFO63829.1 - 0.0049 16.9 0.0 0.012 15.7 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II DUF531 PF04407.12 EFO63830.1 - 0.025 14.7 0.1 0.065 13.3 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF531) GCP_N_terminal PF17681.1 EFO63831.1 - 3.9e-35 121.9 3.3 5.2e-35 121.5 1.5 2.0 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EFO63831.1 - 2.8e-17 63.1 0.6 5.7e-17 62.1 0.6 1.6 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal BRCA-2_OB1 PF09103.10 EFO63833.1 - 2.4e-07 30.7 0.0 6.2e-07 29.4 0.0 1.8 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 Brix PF04427.18 EFO63834.1 - 8.9e-09 35.7 0.0 1.4e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Brix domain Tho2 PF11262.8 EFO63834.1 - 0.56 9.4 4.8 0.73 9.0 4.8 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 VSP PF03302.13 EFO63835.1 - 1.6e-53 182.0 133.0 4.9e-36 124.4 57.0 4.9 1 1 3 4 4 4 4 Giardia variant-specific surface protein zf-C2H2_4 PF13894.6 EFO63837.1 - 1.6e-06 28.4 1.4 0.1 13.5 0.6 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFO63837.1 - 3.1e-06 27.3 1.3 0.012 15.9 0.5 2.3 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EFO63837.1 - 5.6e-05 23.4 0.8 0.23 12.0 0.0 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-met PF12874.7 EFO63837.1 - 0.00023 21.4 1.2 0.098 13.1 0.0 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_9 PF16293.5 EFO63837.1 - 0.00035 20.3 1.5 0.0079 16.0 0.1 2.3 2 0 0 2 2 2 1 C2H2 type zinc-finger (1 copy) zf-Di19 PF05605.12 EFO63837.1 - 0.00041 20.6 1.6 0.35 11.2 0.3 2.3 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 EFO63837.1 - 0.0025 18.1 0.2 1.8 9.0 0.2 2.2 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) Zn-C2H2_12 PF18112.1 EFO63837.1 - 0.0026 18.2 1.4 0.95 10.0 0.6 2.4 2 0 0 2 2 2 2 Autophagy receptor zinc finger-C2H2 domain zf_C2H2_6 PF18450.1 EFO63837.1 - 0.11 12.2 3.0 0.62 9.8 0.2 2.4 2 0 0 2 2 2 0 Zinc Finger domain zf-H2C2_2 PF13465.6 EFO63837.1 - 0.12 12.9 3.6 2 9.0 0.8 2.5 2 0 0 2 2 2 0 Zinc-finger double domain Peptidase_M26_N PF05342.14 EFO63838.1 - 0.0036 16.7 0.0 0.0051 16.2 0.0 1.2 1 0 0 1 1 1 1 M26 IgA1-specific Metallo-endopeptidase N-terminal region Glug PF07581.12 EFO63838.1 - 0.15 12.5 8.4 7.4 7.2 0.2 3.8 3 0 0 3 3 3 0 The GLUG motif FHA PF00498.26 EFO63841.1 - 2.4e-05 24.6 0.0 4.6e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 FHA domain BRCT PF00533.26 EFO63841.1 - 0.00016 22.0 0.5 0.00043 20.6 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Ndc1_Nup PF09531.10 EFO63841.1 - 0.0058 15.4 2.1 0.0075 15.0 2.1 1.1 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup RTT107_BRCT_5 PF16770.5 EFO63841.1 - 0.033 14.1 1.8 0.046 13.6 0.0 2.1 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain DUF2138 PF09909.9 EFO63841.1 - 0.07 11.4 0.0 0.11 10.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2138) DUF966 PF06136.13 EFO63841.1 - 0.34 10.6 11.3 0.47 10.1 11.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Histone PF00125.24 EFO63842.1 - 9e-43 145.8 5.5 1e-42 145.6 5.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EFO63842.1 - 8.9e-05 22.8 0.0 0.00023 21.5 0.0 1.7 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 EFO63842.1 - 0.00022 21.8 2.9 0.00024 21.7 2.9 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 EFO63842.1 - 0.00027 21.0 2.2 0.0007 19.7 0.0 2.3 1 1 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 EFO63842.1 - 0.0013 18.6 0.0 0.0025 17.8 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 EFO63842.1 - 0.0043 17.1 0.0 0.0076 16.3 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 EFO63842.1 - 0.039 14.3 3.8 0.062 13.6 0.1 2.6 2 1 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone zf_CCCH_4 PF18345.1 EFO63843.1 - 5e-08 32.8 26.8 3.1e-05 23.9 2.1 5.2 5 0 0 5 5 5 3 Zinc finger domain zf-CCCH_4 PF18044.1 EFO63843.1 - 1.6e-06 27.7 25.8 0.00086 19.1 0.8 4.3 5 0 0 5 5 5 3 CCCH-type zinc finger Torus PF16131.5 EFO63843.1 - 7.6e-06 26.6 19.4 0.0021 18.7 1.4 3.9 2 1 1 4 4 4 3 Torus domain zf-CCCH PF00642.24 EFO63843.1 - 0.002 18.0 7.9 0.019 14.9 0.8 4.9 5 0 0 5 5 5 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EFO63843.1 - 0.053 14.0 6.4 0.053 14.0 6.4 4.2 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 EFO63843.1 - 0.057 13.6 19.2 0.15 12.2 7.8 3.5 1 1 3 4 4 4 0 Zinc-finger containing family DUF1972 PF09314.11 EFO63844.1 - 0.073 12.7 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1972) zf-C2H2_4 PF13894.6 EFO63845.1 - 1.8e-07 31.4 23.2 0.17 12.8 1.0 5.7 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFO63845.1 - 2.2e-07 31.0 13.1 0.015 15.5 0.9 4.6 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EFO63845.1 - 3.9e-06 27.0 26.7 0.6 10.7 0.5 5.7 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-met PF12874.7 EFO63845.1 - 4.8e-06 26.8 12.2 0.68 10.4 0.0 5.0 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EFO63845.1 - 0.0007 19.9 14.2 1.8 8.9 1.3 4.9 4 1 1 5 5 5 2 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 EFO63845.1 - 0.01 15.7 15.9 0.06 13.2 0.1 5.0 5 0 0 5 5 5 0 C2H2 type zinc-finger (1 copy) zf-C2H2_11 PF16622.5 EFO63845.1 - 0.094 12.5 8.1 0.12 12.2 1.1 3.0 3 0 0 3 3 3 0 zinc-finger C2H2-type DUF4187 PF13821.6 EFO63845.1 - 0.35 10.7 4.4 17 5.3 0.2 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4187) VSP PF03302.13 EFO63846.1 - 1.2e-16 60.6 167.4 1.3e-06 27.6 48.1 7.4 1 1 7 8 8 8 6 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO63846.1 - 0.0087 16.2 17.5 0.0087 16.2 17.5 10.4 1 1 11 12 12 12 5 Furin-like repeat, cysteine-rich SKG6 PF08693.10 EFO63846.1 - 4.3 6.8 16.6 8.1 6.0 16.6 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Pkinase PF00069.25 EFO63847.1 - 3.8e-65 219.9 0.0 5.9e-65 219.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63847.1 - 4.3e-30 104.9 0.0 6.7e-30 104.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO63847.1 - 3.4e-08 33.2 0.1 0.00013 21.4 0.0 2.3 2 1 0 2 2 2 2 Kinase-like Pkinase_C PF00433.24 EFO63847.1 - 0.0015 19.2 0.9 0.0047 17.6 0.9 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Myosin_TH1 PF06017.13 EFO63847.1 - 0.0017 18.1 1.1 0.0025 17.5 0.1 1.8 2 0 0 2 2 2 1 Unconventional myosin tail, actin- and lipid-binding Haspin_kinase PF12330.8 EFO63847.1 - 0.0044 16.0 0.1 0.0065 15.5 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain YrbL-PhoP_reg PF10707.9 EFO63847.1 - 0.41 10.1 2.4 18 4.8 0.1 2.8 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL Ydc2-catalyt PF09159.10 EFO63848.1 - 0.0051 16.6 0.0 0.0066 16.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 MAGUK_N_PEST PF10608.9 EFO63848.1 - 0.031 14.7 0.0 0.041 14.3 0.0 1.3 1 0 0 1 1 1 0 Polyubiquitination (PEST) N-terminal domain of MAGUK TraE PF05309.11 EFO63848.1 - 0.068 12.6 0.1 0.15 11.5 0.1 1.6 1 0 0 1 1 1 0 TraE protein Sarcoglycan_1 PF04790.13 EFO63848.1 - 0.15 11.4 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 Sarcoglycan complex subunit protein DUF3681 PF12442.8 EFO63848.1 - 1.1 9.7 7.4 9.2 6.8 0.5 3.4 3 1 0 4 4 4 0 Protein of unknown function (DUF3681) Orn_Arg_deC_N PF02784.16 EFO63849.1 - 2.7e-54 184.1 0.0 4.2e-54 183.5 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EFO63849.1 - 2e-10 40.8 0.0 3.3e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.24 EFO63849.1 - 0.0088 15.5 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel EAGR_box PF16713.5 EFO63849.1 - 1.5 8.5 4.3 3.4 7.4 4.3 1.5 1 0 0 1 1 1 0 Enriched in aromatic and glycine Residues box TLE_N PF03920.15 EFO63850.1 - 0.0026 17.8 4.7 0.75 9.9 0.1 3.8 3 0 0 3 3 3 2 Groucho/TLE N-terminal Q-rich domain CASP_C PF08172.12 EFO63850.1 - 0.016 14.5 0.2 0.016 14.5 0.2 4.3 5 0 0 5 5 5 0 CASP C terminal YabA PF06156.13 EFO63850.1 - 0.077 13.6 50.0 0.35 11.5 2.9 8.9 6 3 3 9 9 9 0 Initiation control protein YabA Scaffolding_pro PF11418.8 EFO63850.1 - 0.11 13.1 0.1 0.11 13.1 0.1 5.2 6 0 0 6 6 6 0 Phi29 scaffolding protein Bap31_Bap29_C PF18035.1 EFO63850.1 - 0.13 12.2 1.7 1.7 8.7 0.1 3.5 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Cnn_1N PF07989.11 EFO63850.1 - 0.16 12.2 0.1 0.16 12.2 0.1 7.9 7 3 0 7 7 7 0 Centrosomin N-terminal motif 1 IF-2B PF01008.17 EFO63850.1 - 0.16 11.1 2.4 0.3 10.3 0.3 2.5 2 0 0 2 2 2 0 Initiation factor 2 subunit family Phage_GP20 PF06810.11 EFO63850.1 - 0.89 9.3 21.2 1.3 8.9 0.4 5.8 6 0 0 6 6 6 0 Phage minor structural protein GP20 Ribosomal_S4e PF00900.20 EFO63851.1 - 1.1e-31 108.6 0.2 2.4e-31 107.4 0.2 1.6 2 0 0 2 2 2 1 Ribosomal family S4e RS4NT PF08071.12 EFO63851.1 - 1.8e-18 66.4 4.4 3.4e-18 65.5 4.4 1.5 1 0 0 1 1 1 1 RS4NT (NUC023) domain 40S_S4_C PF16121.5 EFO63851.1 - 3e-11 42.8 0.0 6.3e-11 41.8 0.0 1.6 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus KOW PF00467.29 EFO63851.1 - 0.00026 20.8 0.1 0.00073 19.4 0.1 1.8 1 0 0 1 1 1 1 KOW motif S4 PF01479.25 EFO63851.1 - 0.00059 19.5 0.0 0.00092 18.9 0.0 1.3 1 0 0 1 1 1 1 S4 domain Ank_2 PF12796.7 EFO63853.1 - 1e-57 192.7 30.8 1.4e-13 51.2 0.0 10.0 6 2 3 10 10 10 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63853.1 - 6.7e-29 99.6 28.7 0.00081 19.6 0.1 13.5 6 4 8 14 14 14 12 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63853.1 - 2.9e-28 97.9 27.4 4.9e-05 23.8 0.1 13.0 7 3 8 15 15 15 12 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63853.1 - 4.8e-21 72.6 30.1 0.34 11.6 0.0 15.2 17 0 0 17 17 17 7 Ankyrin repeat Ank PF00023.30 EFO63853.1 - 1e-18 66.9 21.7 0.23 12.0 0.0 12.5 12 2 0 12 12 12 6 Ankyrin repeat Pkinase PF00069.25 EFO63853.1 - 0.00011 21.7 0.0 0.097 12.0 0.0 3.0 1 1 0 1 1 1 1 Protein kinase domain AMP_N PF05195.16 EFO63854.1 - 0.062 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Aminopeptidase P, N-terminal domain Bowman-Birk_leg PF00228.20 EFO63854.1 - 0.46 11.0 2.4 0.99 9.9 2.4 1.6 1 0 0 1 1 1 0 Bowman-Birk serine protease inhibitor family AAA_6 PF12774.7 EFO63855.1 - 4.2e-54 183.7 4.9 3e-47 161.2 0.1 4.6 3 1 1 4 4 4 2 Hydrolytic ATP binding site of dynein motor region MT PF12777.7 EFO63855.1 - 2.3e-32 112.4 4.7 4.3e-32 111.5 4.7 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.7 EFO63855.1 - 6.3e-25 87.7 1.6 1.1e-21 77.1 0.0 4.6 5 0 0 5 5 5 1 P-loop containing dynein motor region DHC_N2 PF08393.13 EFO63855.1 - 4.4e-19 68.9 3.0 2e-18 66.7 1.2 5.1 6 0 0 6 6 6 2 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 EFO63855.1 - 1.3e-16 60.5 0.1 9.3e-16 57.6 0.0 2.6 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_8 PF12780.7 EFO63855.1 - 1.7e-13 50.5 0.7 6e-12 45.4 0.1 2.9 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_5 PF07728.14 EFO63855.1 - 2.2e-13 50.4 0.0 0.0013 18.7 0.0 5.4 6 0 0 6 6 5 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFO63855.1 - 1.6e-09 38.2 0.0 4.1e-05 23.9 0.0 4.3 4 0 0 4 4 2 2 AAA domain AAA_16 PF13191.6 EFO63855.1 - 9.1e-08 32.7 0.0 0.0041 17.5 0.0 5.0 3 0 0 3 3 3 1 AAA ATPase domain AAA_lid_11 PF18198.1 EFO63855.1 - 1.4e-07 31.4 0.1 4.5e-07 29.8 0.1 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA PF00004.29 EFO63855.1 - 2e-06 28.2 0.0 0.041 14.3 0.0 3.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EFO63855.1 - 6.8e-05 22.9 0.0 0.0014 18.7 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_lid_7 PF17867.1 EFO63855.1 - 0.001 19.3 2.8 0.0022 18.2 0.1 3.1 3 0 0 3 3 2 1 Midasin AAA lid domain AAA_18 PF13238.6 EFO63855.1 - 0.0021 18.6 0.0 5.4 7.6 0.0 3.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFO63855.1 - 0.0033 17.6 0.2 2.5 8.3 0.0 3.7 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EFO63855.1 - 0.0037 17.0 0.1 1.1 8.9 0.0 3.0 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EFO63855.1 - 0.0068 16.2 0.0 0.036 13.8 0.0 2.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 EFO63855.1 - 0.016 14.9 0.0 9 6.0 0.0 2.8 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EFO63855.1 - 0.017 15.1 0.1 0.71 9.9 0.0 3.3 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 EFO63855.1 - 0.019 15.3 0.2 1.3 9.3 0.1 3.3 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 EFO63855.1 - 0.024 14.5 0.1 0.26 11.2 0.0 3.0 3 0 0 3 3 2 0 NACHT domain NB-ARC PF00931.22 EFO63855.1 - 0.025 13.8 0.0 0.16 11.1 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain ABC_tran PF00005.27 EFO63855.1 - 0.039 14.5 0.0 0.24 11.9 0.0 2.4 1 0 0 1 1 1 0 ABC transporter cobW PF02492.19 EFO63855.1 - 0.087 12.4 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain YlaC PF10777.9 EFO63855.1 - 0.088 12.6 0.2 0.25 11.2 0.2 1.8 1 0 0 1 1 1 0 Inner membrane protein YlaC AAA_28 PF13521.6 EFO63855.1 - 0.16 12.2 1.6 6.7 6.9 0.0 3.6 3 0 0 3 3 3 0 AAA domain Med4 PF10018.9 EFO63855.1 - 0.93 9.1 2.8 4.3 7.0 2.8 2.1 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF4229 PF14012.6 EFO63856.1 - 0.2 11.8 0.1 0.2 11.8 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4229) ELFV_dehydrog PF00208.21 EFO63857.1 - 2e-80 270.0 0.2 2.7e-80 269.6 0.2 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EFO63857.1 - 3e-51 172.7 0.0 5.1e-51 171.9 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NAD_binding_7 PF13241.6 EFO63857.1 - 0.0028 18.1 0.0 0.0056 17.1 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding VID27 PF08553.10 EFO63858.1 - 4e-29 101.8 0.0 6.6e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain IPPT PF01715.17 EFO63859.1 - 6e-20 72.0 0.2 9.5e-09 35.4 0.2 2.8 1 1 1 2 2 2 2 IPP transferase AAA_33 PF13671.6 EFO63859.1 - 5.2e-06 26.7 0.4 0.0073 16.5 0.0 2.9 3 1 0 3 3 3 2 AAA domain zf-C2H2_jaz PF12171.8 EFO63859.1 - 2e-05 24.7 0.0 4.4e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFO63859.1 - 2.1e-05 24.7 0.1 2.1e-05 24.7 0.1 2.2 2 0 0 2 2 2 1 Zinc-finger of C2H2 type IPT PF01745.16 EFO63859.1 - 6.3e-05 22.5 0.0 0.00065 19.2 0.0 2.2 2 0 0 2 2 2 1 Isopentenyl transferase zf-C2H2_2 PF12756.7 EFO63859.1 - 0.049 14.0 0.5 0.14 12.5 0.5 1.8 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) KTI12 PF08433.10 EFO63859.1 - 0.051 13.0 0.0 0.089 12.2 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 zf-DBF PF07535.12 EFO63859.1 - 0.097 12.8 0.3 0.22 11.7 0.3 1.6 1 0 0 1 1 1 0 DBF zinc finger NRBF2 PF08961.10 EFO63860.1 - 1e-06 28.5 4.8 6.7e-05 22.6 2.0 2.1 1 1 1 2 2 2 2 Nuclear receptor-binding factor 2, autophagy regulator YabA PF06156.13 EFO63860.1 - 0.011 16.3 0.3 0.02 15.5 0.3 1.3 1 0 0 1 1 1 0 Initiation control protein YabA DivIC PF04977.15 EFO63860.1 - 0.02 14.7 1.8 0.073 12.8 1.7 1.9 1 1 0 1 1 1 0 Septum formation initiator bZIP_1 PF00170.21 EFO63860.1 - 0.029 14.4 0.4 0.057 13.5 0.4 1.6 1 0 0 1 1 1 0 bZIP transcription factor ZapB PF06005.12 EFO63860.1 - 0.03 14.8 1.5 0.044 14.2 1.5 1.2 1 0 0 1 1 1 0 Cell division protein ZapB HSBP1 PF06825.12 EFO63860.1 - 0.042 13.7 0.5 0.064 13.1 0.5 1.3 1 0 0 1 1 1 0 Heat shock factor binding protein 1 DUF5101 PF17031.5 EFO63860.1 - 0.1 12.7 0.5 0.16 12.1 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5101) HALZ PF02183.18 EFO63860.1 - 0.39 11.0 1.8 0.95 9.7 0.2 2.0 2 1 0 2 2 2 0 Homeobox associated leucine zipper TSC22 PF01166.18 EFO63860.1 - 1.8 8.9 4.1 8 6.9 0.5 2.5 2 1 1 3 3 3 0 TSC-22/dip/bun family Cpn60_TCP1 PF00118.24 EFO63861.1 - 3.7e-139 464.5 5.4 4.2e-139 464.4 5.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family KTI12 PF08433.10 EFO63862.1 - 4.5e-57 193.6 0.0 5.1e-57 193.4 0.0 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 EFO63862.1 - 5.1e-06 26.7 0.1 8.7e-06 26.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFO63862.1 - 0.082 13.3 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFO63862.1 - 0.098 13.0 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 EFO63862.1 - 0.12 11.6 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin DnaJ_C PF01556.18 EFO63863.1 - 7.2e-37 126.7 0.0 9.2e-37 126.4 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFO63863.1 - 2.3e-26 91.7 0.7 3.9e-26 91.0 0.7 1.4 1 0 0 1 1 1 1 DnaJ domain Pkinase PF00069.25 EFO63864.1 - 1.4e-40 139.3 0.0 2.4e-40 138.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EFO63864.1 - 5.2e-34 116.7 1.1 1.4e-10 41.6 0.4 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EFO63864.1 - 5.6e-25 88.1 0.0 9.7e-25 87.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_3 PF13606.6 EFO63864.1 - 3.4e-21 73.0 0.1 0.0099 16.3 0.1 6.7 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.6 EFO63864.1 - 3.6e-21 74.9 2.1 5.3e-07 29.8 0.6 6.0 1 1 5 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO63864.1 - 2.3e-18 65.7 0.3 0.0044 17.4 0.1 6.5 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 EFO63864.1 - 4e-18 65.5 0.1 0.00017 22.1 0.0 6.1 3 2 3 6 6 6 5 Ankyrin repeats (many copies) APH PF01636.23 EFO63864.1 - 0.0011 19.0 0.0 0.0022 18.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFO63864.1 - 0.075 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase SHIPPO-rpt PF07004.12 EFO63866.1 - 9.8e-09 35.7 8.7 11 7.2 0.0 8.4 8 0 0 8 8 8 5 Sperm-tail PG-rich repeat Ank_2 PF12796.7 EFO63867.1 - 6.4e-56 186.9 11.3 1.3e-13 51.3 0.4 5.4 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63867.1 - 1.7e-37 126.9 10.9 6.6e-05 23.1 0.0 8.5 2 2 6 8 8 8 8 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63867.1 - 4.5e-37 126.0 7.1 4e-08 33.6 0.1 7.0 6 0 0 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO63867.1 - 1.5e-32 110.6 11.6 0.00087 19.6 0.0 9.9 10 0 0 10 10 9 8 Ankyrin repeat Ank_3 PF13606.6 EFO63867.1 - 2.2e-29 98.2 9.7 0.02 15.4 0.1 10.6 11 0 0 11 11 10 7 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO63867.1 - 6.4e-11 41.9 5.8 1.7e-10 40.6 5.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO63867.1 - 7.5e-05 22.5 10.0 0.00019 21.2 10.0 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFO63867.1 - 0.00028 21.1 9.2 0.00091 19.5 9.2 2.0 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFO63867.1 - 0.017 14.9 10.0 0.017 14.9 10.0 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) PHF5 PF03660.14 EFO63867.1 - 0.15 12.3 0.9 0.38 11.0 0.9 1.6 1 0 0 1 1 1 0 PHF5-like protein zf-RING_11 PF17123.5 EFO63867.1 - 1.8 8.4 5.3 0.49 10.2 1.5 2.1 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_UBOX PF13445.6 EFO63867.1 - 4.9 7.3 9.3 5.3 7.2 6.8 2.5 2 1 0 2 2 2 0 RING-type zinc-finger SMC_N PF02463.19 EFO63868.1 - 8.4e-13 48.3 0.0 4.6e-12 45.8 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Synaptonemal_3 PF15191.6 EFO63868.1 - 0.036 13.8 2.0 0.11 12.2 0.5 2.6 2 0 0 2 2 2 0 Synaptonemal complex central element protein 3 Spc7 PF08317.11 EFO63868.1 - 0.39 9.6 28.4 0.15 10.9 4.6 3.5 2 1 0 2 2 2 0 Spc7 kinetochore protein HCMV_UL139 PF12507.8 EFO63868.1 - 3.3 8.1 7.7 3.5 8.0 1.0 3.3 2 1 1 3 3 3 0 Human Cytomegalovirus UL139 protein DUF948 PF06103.11 EFO63868.1 - 3.9 7.8 9.7 1.7 9.0 0.2 3.9 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Seryl_tRNA_N PF02403.22 EFO63868.1 - 4.8 7.5 19.8 0.93 9.8 6.2 3.8 3 1 1 4 4 4 0 Seryl-tRNA synthetase N-terminal domain UN_NPL4 PF11543.8 EFO63869.1 - 3.3e-08 33.9 1.9 5.7e-08 33.1 0.2 2.3 2 0 0 2 2 2 1 Nuclear pore localisation protein NPL4 NPL4 PF05021.15 EFO63869.1 - 3.8e-07 29.8 0.0 0.00013 21.5 0.0 2.9 2 1 0 2 2 2 2 NPL4 family YliH PF10799.8 EFO63869.1 - 0.12 12.3 1.6 0.17 11.8 0.2 2.0 2 1 0 2 2 2 0 Biofilm formation protein (YliH/bssR) DEAD PF00270.29 EFO63871.1 - 1.4e-32 112.9 0.4 2.9e-32 111.9 0.4 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO63871.1 - 2.8e-22 79.1 0.4 7.4e-22 77.8 0.1 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFO63871.1 - 0.00032 20.7 0.0 0.0011 19.0 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EFO63871.1 - 0.066 13.5 0.5 0.21 11.9 0.5 1.8 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFO63871.1 - 0.1 12.9 1.1 2.1 8.6 1.1 2.9 1 1 0 1 1 1 0 AAA domain WD40 PF00400.32 EFO63873.1 - 2.3e-16 59.9 19.7 7.9e-06 26.5 0.1 9.9 12 0 0 12 12 12 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO63873.1 - 9.1e-13 48.3 0.0 0.45 10.9 0.0 6.6 3 3 1 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain AAA_12 PF13087.6 EFO63875.1 - 7.6e-53 179.1 0.0 3.2e-52 177.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EFO63875.1 - 2.2e-34 119.4 0.1 5e-34 118.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain UPF1_Zn_bind PF09416.10 EFO63875.1 - 1.4e-15 57.6 3.6 6e-15 55.5 3.6 2.2 1 0 0 1 1 1 1 RNA helicase (UPF2 interacting domain) AAA_30 PF13604.6 EFO63875.1 - 6.2e-08 32.6 0.0 0.00021 21.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EFO63875.1 - 6.8e-05 23.2 0.1 0.00036 20.9 0.0 2.3 3 0 0 3 3 3 1 AAA domain Viral_helicase1 PF01443.18 EFO63875.1 - 0.00014 21.7 1.5 0.13 12.0 0.0 3.4 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 EFO63875.1 - 0.0096 15.4 0.0 0.031 13.7 0.0 1.8 2 0 0 2 2 2 1 PhoH-like protein AAA_22 PF13401.6 EFO63875.1 - 0.073 13.4 0.1 0.9 9.8 0.0 2.7 3 0 0 3 3 3 0 AAA domain DEAD PF00270.29 EFO63875.1 - 0.08 12.7 0.0 0.97 9.2 0.0 2.4 1 1 0 1 1 1 0 DEAD/DEAH box helicase zf-UBP PF02148.19 EFO63875.1 - 0.56 10.6 4.9 2.2 8.7 4.9 2.1 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein AAA_23 PF13476.6 EFO63875.1 - 0.76 10.2 6.6 0.088 13.3 0.4 2.6 2 1 0 2 2 2 0 AAA domain zf-MYND PF01753.18 EFO63876.1 - 1.7e-06 28.0 15.2 1.7e-06 28.0 15.2 2.1 2 0 0 2 2 2 1 MYND finger VSP PF03302.13 EFO63877.1 - 2e-46 158.6 103.7 4.4e-41 141.0 73.9 3.3 1 1 1 2 2 2 2 Giardia variant-specific surface protein MHYT PF03707.16 EFO63877.1 - 0.15 12.3 1.1 0.29 11.3 1.1 1.4 1 0 0 1 1 1 0 Bacterial signalling protein N terminal repeat Ank_2 PF12796.7 EFO63878.1 - 4.5e-57 190.6 9.0 2.4e-15 56.9 0.1 5.3 2 1 5 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63878.1 - 1.9e-30 104.8 0.7 7.2e-08 32.8 0.0 7.0 4 3 3 7 7 7 7 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO63878.1 - 1.8e-29 102.9 0.0 3.8e-29 101.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ank_5 PF13857.6 EFO63878.1 - 3.4e-28 97.3 2.5 2.4e-05 24.5 0.0 7.3 1 1 7 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63878.1 - 1.3e-25 86.7 0.5 0.0067 16.9 0.0 8.7 8 0 0 8 8 8 6 Ankyrin repeat Ank PF00023.30 EFO63878.1 - 4.7e-23 80.6 1.5 0.02 15.4 0.0 8.6 8 0 0 8 8 8 6 Ankyrin repeat Pkinase_Tyr PF07714.17 EFO63878.1 - 1.7e-17 63.6 0.0 2.8e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase pXO2-72 PF17443.2 EFO63878.1 - 0.022 15.0 0.4 5 7.5 0.0 3.2 3 0 0 3 3 3 0 Uncharacterized protein pXO2-72 cNMP_binding PF00027.29 EFO63878.1 - 0.13 12.3 0.1 0.78 9.9 0.0 2.3 1 1 1 2 2 2 0 Cyclic nucleotide-binding domain DUF848 PF05852.11 EFO63878.1 - 0.2 11.8 0.1 0.98 9.5 0.0 2.1 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Ank_2 PF12796.7 EFO63879.1 - 8.4e-32 109.6 0.5 8.9e-15 55.1 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63879.1 - 6.6e-16 58.5 0.2 7.4e-06 26.4 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63879.1 - 8.4e-16 56.5 0.1 0.0028 18.0 0.0 4.9 4 1 1 5 5 5 3 Ankyrin repeat Ank PF00023.30 EFO63879.1 - 1.8e-15 56.6 0.1 0.00078 19.8 0.0 4.6 4 1 1 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EFO63879.1 - 4e-15 55.7 1.9 0.00035 20.8 0.0 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) HTH_Tnp_1_2 PF13022.6 EFO63879.1 - 0.014 15.6 0.1 0.033 14.4 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix of insertion element transposase CENP-T_C PF15511.6 EFO63880.1 - 1.2e-09 38.2 0.1 1.5e-09 38.0 0.1 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EFO63880.1 - 1.9e-05 25.1 0.2 2.4e-05 24.7 0.2 1.2 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EFO63880.1 - 6e-05 23.1 0.0 7.3e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit TAF PF02969.17 EFO63880.1 - 0.00014 21.9 0.0 0.00022 21.3 0.0 1.3 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EFO63880.1 - 0.00032 20.9 0.0 0.00045 20.5 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EFO63880.1 - 0.00059 20.2 0.1 0.00089 19.6 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein Bromo_TP PF07524.13 EFO63880.1 - 0.14 12.1 0.0 0.24 11.4 0.0 1.4 1 1 0 1 1 1 0 Bromodomain associated Mannosyl_trans2 PF04188.13 EFO63881.1 - 3.8e-21 75.9 17.8 3.8e-21 75.9 17.8 1.9 2 1 0 2 2 2 1 Mannosyltransferase (PIG-V) Ank_2 PF12796.7 EFO63882.1 - 6e-29 100.5 4.2 7e-10 39.4 0.0 3.9 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO63882.1 - 5.1e-16 58.8 0.0 2.3e-15 56.7 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Ank_5 PF13857.6 EFO63882.1 - 2.9e-12 46.6 11.4 0.0026 18.1 0.0 6.6 2 1 5 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO63882.1 - 2.1e-11 43.7 2.0 0.093 13.2 0.0 5.8 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.6 EFO63882.1 - 3.7e-11 42.2 2.8 1.5 9.6 0.0 6.4 6 0 0 6 6 6 3 Ankyrin repeat Ank_4 PF13637.6 EFO63882.1 - 4.7e-11 43.0 1.7 0.081 13.5 0.2 4.6 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO63882.1 - 1.1e-09 38.0 0.0 1.9e-08 33.9 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase AAA_6 PF12774.7 EFO63884.1 - 1.2e-127 425.5 0.0 9.7e-125 415.9 0.0 2.7 1 1 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFO63884.1 - 2.3e-118 395.8 2.6 2.3e-118 395.8 2.6 4.5 7 0 0 7 7 6 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 EFO63884.1 - 3.5e-94 316.5 9.6 1.8e-55 188.7 0.0 3.9 4 0 0 4 4 4 2 Dynein heavy chain, N-terminal region 1 AAA_8 PF12780.7 EFO63884.1 - 1.7e-89 299.6 0.0 4.3e-89 298.3 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 EFO63884.1 - 5e-78 261.2 0.9 5e-78 261.2 0.9 4.2 5 1 0 5 5 3 1 ATP-binding dynein motor region Dynein_C PF18199.1 EFO63884.1 - 2.4e-77 260.2 0.1 8.9e-77 258.3 0.1 2.1 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 EFO63884.1 - 5.8e-60 201.9 0.2 4.8e-55 185.9 0.0 3.6 3 0 0 3 3 3 2 P-loop containing dynein motor region MT PF12777.7 EFO63884.1 - 2.8e-49 168.0 15.6 7.1e-49 166.7 15.6 1.7 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 EFO63884.1 - 2.1e-44 151.2 0.7 3.7e-43 147.2 0.7 2.8 1 1 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 EFO63884.1 - 1.1e-39 135.2 0.3 2.1e-36 124.6 0.3 4.4 4 1 0 4 4 3 1 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 EFO63884.1 - 1.3e-20 73.8 0.0 1.3e-19 70.6 0.0 2.9 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 EFO63884.1 - 5.1e-16 58.9 0.0 0.00065 19.7 0.0 5.6 5 1 0 5 5 4 3 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 EFO63884.1 - 5.6e-15 55.4 0.0 2.1e-14 53.5 0.0 2.1 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EFO63884.1 - 4.9e-07 30.3 5.9 0.17 12.3 0.0 6.7 6 0 0 6 6 5 1 AAA ATPase domain AAA PF00004.29 EFO63884.1 - 1.9e-06 28.4 0.7 0.1 13.1 0.0 4.9 5 0 0 5 5 4 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFO63884.1 - 7.9e-06 26.2 2.6 1.4 9.2 0.0 5.8 6 0 0 6 6 4 1 AAA domain TniB PF05621.11 EFO63884.1 - 2.1e-05 24.0 0.0 0.1 12.0 0.0 3.6 4 0 0 4 4 4 2 Bacterial TniB protein TolA_bind_tri PF16331.5 EFO63884.1 - 0.0021 18.1 8.3 0.0021 18.1 8.3 4.0 3 0 0 3 3 3 1 TolA binding protein trimerisation Roc PF08477.13 EFO63884.1 - 0.014 15.6 0.0 1.7 8.9 0.0 3.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 EFO63884.1 - 0.021 14.6 0.0 2.3 7.9 0.0 3.5 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_33 PF13671.6 EFO63884.1 - 0.028 14.6 0.1 17 5.5 0.0 4.1 3 0 0 3 3 3 0 AAA domain ATPase PF06745.13 EFO63884.1 - 0.044 13.1 0.3 7.3 5.9 0.0 3.4 3 0 0 3 3 2 0 KaiC Spo7_2_N PF15407.6 EFO63884.1 - 0.077 12.6 0.0 0.69 9.6 0.0 2.5 2 0 0 2 2 2 0 Sporulation protein family 7 RNA_helicase PF00910.22 EFO63884.1 - 0.14 12.5 0.1 1.4e+02 2.9 0.0 3.9 3 0 0 3 3 3 0 RNA helicase AAA_18 PF13238.6 EFO63884.1 - 0.4 11.2 1.5 14 6.3 0.0 4.2 4 0 0 4 4 4 0 AAA domain DUF16 PF01519.16 EFO63884.1 - 0.72 10.4 20.4 0.12 12.9 3.3 4.3 3 1 0 3 3 2 0 Protein of unknown function DUF16 Spc7 PF08317.11 EFO63884.1 - 2.9 6.7 31.0 1.8 7.4 9.1 4.4 4 0 0 4 4 4 0 Spc7 kinetochore protein GTP_EFTU PF00009.27 EFO63885.1 - 2.6e-30 105.4 0.0 2.5e-29 102.2 0.0 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EFO63885.1 - 1.4e-15 57.3 0.1 3.6e-15 56.0 0.1 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 EFO63885.1 - 8.6e-12 44.8 0.0 3.5e-11 42.8 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.25 EFO63885.1 - 3.5e-10 40.1 0.4 1.2e-07 32.0 0.1 3.2 3 0 0 3 3 3 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFO63885.1 - 3.2e-07 30.4 0.8 2.2e-06 27.7 0.0 2.8 3 0 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 EFO63885.1 - 2.5e-05 24.5 0.0 8.6e-05 22.7 0.0 2.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EFO63885.1 - 0.00023 21.1 0.8 0.0062 16.5 0.3 3.1 1 1 1 2 2 2 1 RsgA GTPase ATP_bind_1 PF03029.17 EFO63885.1 - 0.002 17.9 0.0 0.022 14.6 0.0 2.9 1 1 0 2 2 2 1 Conserved hypothetical ATP binding protein Ras PF00071.22 EFO63885.1 - 0.033 13.8 0.0 0.2 11.3 0.0 2.4 1 1 0 1 1 1 0 Ras family SRPRB PF09439.10 EFO63885.1 - 0.17 11.3 0.0 0.17 11.3 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Histone PF00125.24 EFO63886.1 - 3.8e-12 46.7 0.1 5.9e-12 46.1 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFO63886.1 - 2.1e-10 40.7 0.0 3.2e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone_H2A_C PF16211.5 EFO63886.1 - 0.075 12.8 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 C-terminus of histone H2A TFIID-18kDa PF02269.16 EFO63886.1 - 0.12 12.4 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit AAA_29 PF13555.6 EFO63887.1 - 0.0029 17.3 0.1 0.0083 15.8 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFO63887.1 - 0.0085 16.5 0.1 0.063 13.7 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain NTP_transf_2 PF01909.23 EFO63888.1 - 0.012 15.9 0.1 0.027 14.8 0.1 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase domain Polbeta PF18765.1 EFO63888.1 - 0.07 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase HhH-GPD PF00730.25 EFO63889.1 - 9.6e-12 45.3 0.0 2.5e-11 44.0 0.0 1.8 1 1 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EFO63889.1 - 0.036 13.9 0.0 0.16 11.9 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix motif DUF3342 PF11822.8 EFO63890.1 - 4.6e-13 49.2 0.1 1e-12 48.1 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Myb_DNA-binding PF00249.31 EFO63890.1 - 5.7e-06 26.4 0.0 1.7e-05 24.9 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFO63890.1 - 0.0053 17.0 0.0 0.022 15.0 0.0 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EFO63890.1 - 0.059 13.7 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain Fe-ADH PF00465.19 EFO63891.1 - 2.7e-70 237.0 0.0 3.2e-70 236.8 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EFO63891.1 - 9e-05 22.3 0.0 0.0079 15.9 0.0 2.2 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase DUF667 PF05018.13 EFO63892.1 - 2.8e-11 43.5 0.0 7.7e-11 42.1 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF667) DUF3472 PF11958.8 EFO63892.1 - 0.03 14.8 0.0 0.074 13.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3472) WD40_3 PF15911.5 EFO63893.1 - 0.0074 16.3 0.3 0.69 10.0 0.1 2.8 2 1 0 2 2 2 2 WD domain, G-beta repeat Ras PF00071.22 EFO63894.1 - 3.3e-35 121.1 0.1 4.6e-35 120.6 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFO63894.1 - 5.3e-25 88.0 0.3 8.5e-25 87.3 0.3 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFO63894.1 - 3.7e-12 46.0 0.0 5.4e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFO63894.1 - 1.8e-06 27.5 0.2 2.5e-06 27.0 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFO63894.1 - 0.00083 19.4 0.2 0.0021 18.1 0.1 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase G-alpha PF00503.20 EFO63894.1 - 0.00088 18.5 1.2 0.033 13.4 0.4 2.1 1 1 1 2 2 2 2 G-protein alpha subunit TniB PF05621.11 EFO63894.1 - 0.089 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Ras PF00071.22 EFO63895.1 - 1.2e-52 177.8 0.0 1.4e-52 177.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFO63895.1 - 3.4e-24 85.4 0.0 5.9e-24 84.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFO63895.1 - 0.00019 20.9 0.0 0.00027 20.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFO63895.1 - 0.004 16.5 0.0 0.01 15.2 0.0 1.7 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFO63895.1 - 0.0073 15.9 0.2 0.016 14.7 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SAM_1 PF00536.30 EFO63897.1 - 5e-17 62.1 1.1 7.5e-17 61.5 1.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFO63897.1 - 2.1e-16 59.8 0.3 3.4e-16 59.1 0.3 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EFO63897.1 - 0.098 12.6 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Pkinase PF00069.25 EFO63898.1 - 8.3e-63 212.2 0.0 1.3e-44 152.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO63898.1 - 4.2e-29 101.6 0.0 5.4e-23 81.6 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase POLO_box PF00659.18 EFO63898.1 - 1.6e-17 63.5 0.0 2.6e-09 37.1 0.0 2.7 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 EFO63898.1 - 2.9e-06 26.8 0.0 0.001 18.4 0.0 2.6 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EFO63898.1 - 0.005 15.7 0.0 0.0088 14.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Ldl_recept_b PF00058.17 EFO63898.1 - 0.13 12.7 0.0 0.31 11.6 0.0 1.7 1 0 0 1 1 1 0 Low-density lipoprotein receptor repeat class B Kinesin PF00225.23 EFO63899.1 - 1.7e-06 27.2 0.4 2.3e-05 23.5 0.0 2.5 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EFO63899.1 - 0.0013 18.7 0.0 0.003 17.5 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding 6PF2K PF01591.18 EFO63899.1 - 0.021 14.1 0.2 0.049 12.9 0.2 1.5 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Fmp27_WPPW PF10359.9 EFO63899.1 - 0.051 12.4 0.1 0.075 11.9 0.1 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain ZapB PF06005.12 EFO63899.1 - 2.5 8.6 8.7 1.7 9.2 0.5 3.0 2 1 1 3 3 3 0 Cell division protein ZapB FPP PF05911.11 EFO63900.1 - 0.00085 17.6 14.2 0.00085 17.6 14.2 5.1 2 1 3 5 5 5 2 Filament-like plant protein, long coiled-coil Fibritin_C PF07921.12 EFO63900.1 - 0.03 14.5 0.8 0.15 12.2 0.1 2.6 2 0 0 2 2 2 0 Fibritin C-terminal region DMPK_coil PF08826.10 EFO63900.1 - 0.056 13.6 0.4 0.056 13.6 0.4 8.2 9 3 1 10 10 10 0 DMPK coiled coil domain like Tubulin_C PF03953.17 EFO63901.1 - 6.3e-52 175.0 0.1 1.1e-51 174.3 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 EFO63901.1 - 2.4e-10 41.0 0.0 3.9e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Sec2p PF06428.11 EFO63901.1 - 0.095 12.7 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p vATP-synt_E PF01991.18 EFO63902.1 - 3.8e-10 39.5 0.5 5e-10 39.1 0.5 1.1 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit tRNA-synt_2 PF00152.20 EFO63904.1 - 2.2e-79 266.8 0.0 3e-79 266.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFO63904.1 - 1.1e-08 34.9 0.0 2e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EFO63904.1 - 0.0038 16.7 0.1 0.2 11.1 0.0 2.6 3 0 0 3 3 3 1 tRNA synthetases class II core domain (F) Kelch_6 PF13964.6 EFO63905.1 - 0.00011 22.4 0.5 13 6.3 0.1 4.5 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 EFO63905.1 - 0.0073 16.3 0.1 6.4 6.9 0.1 3.6 3 1 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 EFO63905.1 - 0.021 14.8 0.7 6.7 6.8 0.1 3.7 5 0 0 5 5 5 0 Kelch motif Kelch_2 PF07646.15 EFO63905.1 - 0.024 14.6 0.7 7.5 6.7 0.1 2.9 3 0 0 3 3 3 0 Kelch motif Kelch_1 PF01344.25 EFO63905.1 - 0.046 13.3 3.5 0.59 9.8 0.8 3.4 4 0 0 4 4 4 0 Kelch motif AAA_31 PF13614.6 EFO63906.1 - 0.014 15.3 0.3 0.077 12.9 0.1 2.3 2 1 0 2 2 2 0 AAA domain NAGLU PF05089.12 EFO63906.1 - 0.2 10.6 0.0 0.32 9.9 0.0 1.2 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain FAP206 PF12018.8 EFO63907.1 - 3.7e-06 26.7 2.2 2.7e-05 23.8 0.0 2.6 3 0 0 3 3 3 2 Domain of unknown function Proteasome PF00227.26 EFO63909.1 - 5.6e-29 101.0 0.0 7.9e-29 100.5 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFO63909.1 - 1.2e-11 44.0 0.1 3.3e-11 42.7 0.1 1.8 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature IQ PF00612.27 EFO63910.1 - 0.00077 19.0 0.6 0.002 17.8 0.6 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif DUF3022 PF11226.8 EFO63910.1 - 0.16 12.4 1.0 0.85 10.1 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3022) DUF3139 PF11337.8 EFO63911.1 - 0.02 15.5 2.3 0.02 15.5 2.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) Peptidase_M56 PF05569.11 EFO63911.1 - 0.021 14.1 1.1 1.6 7.9 0.0 2.2 2 0 0 2 2 2 0 BlaR1 peptidase M56 AdoMet_Synthase PF01941.19 EFO63911.1 - 0.043 12.6 0.0 0.062 12.1 0.0 1.2 1 0 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) Ferlin_C PF16165.5 EFO63911.1 - 0.31 11.0 1.8 0.71 9.8 1.8 1.5 1 0 0 1 1 1 0 Ferlin C-terminus WD40 PF00400.32 EFO63912.1 - 0.12 13.3 2.5 0.85 10.6 0.3 3.3 2 0 0 2 2 2 0 WD domain, G-beta repeat TPR_1 PF00515.28 EFO63914.1 - 0.0053 16.5 7.5 0.21 11.5 0.2 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFO63914.1 - 0.012 15.8 0.9 13 6.3 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFO63914.1 - 0.26 12.2 5.7 0.36 11.8 0.4 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFO63914.1 - 2.4 8.5 10.0 1.6 9.0 0.3 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat hDGE_amylase PF14701.6 EFO63915.1 - 1.4e-65 222.2 0.0 7.8e-32 110.9 0.0 2.7 2 1 0 2 2 2 2 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 EFO63915.1 - 3.1e-51 174.5 0.3 2.9e-37 128.5 0.0 2.3 2 0 0 2 2 2 2 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 EFO63915.1 - 2.3e-18 66.8 0.6 2.8e-16 59.9 0.0 2.8 2 1 0 2 2 2 1 Central domain of human glycogen debranching enzyme Alpha-amylase PF00128.24 EFO63915.1 - 0.069 12.7 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Alpha amylase, catalytic domain TetR_C_11 PF16859.5 EFO63915.1 - 0.11 12.8 0.1 0.44 10.9 0.0 2.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Peptidase_M24 PF00557.24 EFO63918.1 - 6e-35 120.8 0.0 9.3e-35 120.2 0.0 1.4 1 1 0 1 1 1 1 Metallopeptidase family M24 P-II PF00543.22 EFO63919.1 - 0.0052 17.4 0.0 0.01 16.4 0.0 1.5 1 1 0 1 1 1 1 Nitrogen regulatory protein P-II TolA_bind_tri PF16331.5 EFO63920.1 - 0.0023 18.0 4.8 0.0039 17.2 3.6 2.0 1 1 1 2 2 2 1 TolA binding protein trimerisation HrpB7 PF09486.10 EFO63920.1 - 0.0071 16.7 2.3 0.011 16.1 2.3 1.4 1 1 0 1 1 1 1 Bacterial type III secretion protein (HrpB7) KxDL PF10241.9 EFO63920.1 - 0.19 12.0 3.1 4.4 7.6 1.1 2.5 1 1 1 2 2 2 0 Uncharacterized conserved protein DSPc PF00782.20 EFO63921.1 - 1.5e-13 50.8 0.0 2.8e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DUF4758 PF15950.5 EFO63921.1 - 5.1 7.4 6.6 6.9 7.0 0.0 2.8 3 0 0 3 3 3 0 Putative sperm flagellar membrane protein ATP-grasp_5 PF13549.6 EFO63922.1 - 3.5e-68 229.4 0.3 5.2e-68 228.8 0.3 1.3 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 EFO63922.1 - 3.4e-53 179.2 0.9 5.3e-52 175.3 0.0 2.3 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EFO63922.1 - 4.6e-26 91.6 1.9 8.3e-26 90.8 0.8 2.1 2 0 0 2 2 2 1 CoA binding domain CoA_binding PF02629.19 EFO63922.1 - 1.1e-13 51.7 5.0 1.3e-13 51.4 3.0 2.3 2 0 0 2 2 2 1 CoA binding domain ATP-grasp_2 PF08442.10 EFO63922.1 - 1e-06 28.5 0.7 1.8e-06 27.6 0.7 1.4 1 0 0 1 1 1 1 ATP-grasp domain DapB_N PF01113.20 EFO63922.1 - 0.019 15.1 1.4 0.12 12.5 1.4 2.4 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_2 PF03446.15 EFO63922.1 - 0.022 15.0 0.3 0.12 12.6 0.1 2.3 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase DUF4849 PF16141.5 EFO63922.1 - 0.031 13.6 0.1 0.061 12.6 0.1 1.4 1 0 0 1 1 1 0 Putative glycoside hydrolase Family 18, chitinase_18 FrhB_FdhB_N PF04422.13 EFO63922.1 - 1.2 9.4 3.2 1.3 9.2 0.0 2.8 4 0 0 4 4 4 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term Beach PF02138.18 EFO63923.1 - 1.3e-27 96.9 0.0 1.2e-26 93.8 0.0 2.3 1 1 0 1 1 1 1 Beige/BEACH domain ApoLp-III PF07464.11 EFO63924.1 - 0.029 14.5 0.4 0.029 14.5 0.4 3.3 3 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) ApoO PF09769.9 EFO63924.1 - 0.16 11.9 3.0 11 5.9 0.1 3.1 3 0 0 3 3 3 0 Apolipoprotein O AKNA PF12443.8 EFO63924.1 - 0.33 11.6 4.3 0.34 11.6 0.1 2.9 2 1 1 3 3 3 0 AT-hook-containing transcription factor Cnn_1N PF07989.11 EFO63924.1 - 0.65 10.2 27.5 0.045 13.9 7.4 4.6 2 1 0 3 3 3 0 Centrosomin N-terminal motif 1 LPP PF04728.13 EFO63924.1 - 2.3 8.7 6.7 18 5.8 0.0 3.5 3 0 0 3 3 3 0 Lipoprotein leucine-zipper DUF4407 PF14362.6 EFO63924.1 - 2.9 7.1 20.8 2.4 7.4 10.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 EFO63924.1 - 5.4 7.1 15.3 1.4 9.0 0.4 3.7 3 1 0 4 4 4 0 Protein of unknown function (DUF1664) bZIP_1 PF00170.21 EFO63924.1 - 6.6 6.9 22.8 0.18 12.0 0.9 5.0 3 2 3 6 6 6 0 bZIP transcription factor COPI_assoc PF08507.10 EFO63925.1 - 0.24 11.4 7.4 0.57 10.2 7.4 1.7 1 1 0 1 1 1 0 COPI associated protein Ank_2 PF12796.7 EFO63927.1 - 3.8e-111 363.9 40.0 9.8e-15 54.9 0.0 11.4 2 2 13 15 15 15 14 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO63927.1 - 3.4e-52 168.3 14.5 0.0067 16.9 0.0 18.9 19 0 0 19 19 19 14 Ankyrin repeat Ank PF00023.30 EFO63927.1 - 3.1e-51 169.7 15.5 0.0045 17.4 0.0 17.1 17 1 1 18 18 18 11 Ankyrin repeat Ank_5 PF13857.6 EFO63927.1 - 5.5e-50 166.8 31.1 2.2e-05 24.6 0.0 16.0 6 4 11 17 17 17 14 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63927.1 - 3e-45 152.0 23.2 1.4e-06 28.7 0.0 15.0 5 3 9 16 16 16 12 Ankyrin repeats (many copies) IFT20 PF14931.6 EFO63927.1 - 0.35 11.0 0.0 0.35 11.0 0.0 6.0 3 3 4 7 7 7 0 Intraflagellar transport complex B, subunit 20 DUF1192 PF06698.11 EFO63927.1 - 0.5 10.5 14.1 0.37 10.9 0.5 5.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) DUF724 PF05266.14 EFO63927.1 - 1 9.2 27.4 3.5 7.4 1.1 4.7 4 0 0 4 4 4 0 Protein of unknown function (DUF724) Ank_2 PF12796.7 EFO63928.1 - 2e-14 53.9 1.1 3.4e-07 30.8 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63928.1 - 2.7e-09 37.1 0.3 0.0025 18.1 0.0 3.6 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63928.1 - 0.00034 20.8 0.2 17 6.4 0.0 4.3 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 EFO63928.1 - 0.023 15.2 0.5 53 4.5 0.1 3.9 3 1 1 4 4 4 0 Ankyrin repeat CRISPR_Cas2 PF09827.9 EFO63928.1 - 0.16 12.1 1.1 0.43 10.8 0.4 2.1 2 1 0 2 2 2 0 CRISPR associated protein Cas2 Ank_4 PF13637.6 EFO63928.1 - 0.17 12.5 0.4 58 4.4 0.0 3.1 2 1 1 3 3 3 0 Ankyrin repeats (many copies) TMCO5 PF14992.6 EFO63928.1 - 0.19 11.2 8.4 0.4 10.2 8.4 1.4 1 0 0 1 1 1 0 TMCO5 family Tsc35 PF15079.6 EFO63928.1 - 0.35 10.4 6.3 2.3 7.7 0.1 2.3 2 0 0 2 2 2 0 Testis-specific protein 35 APG6_N PF17675.1 EFO63928.1 - 3.5 8.2 14.0 6.7 7.2 2.3 3.3 2 1 0 2 2 2 0 Apg6 coiled-coil region GCN5L1 PF06320.13 EFO63928.1 - 4.9 7.3 7.3 0.37 10.9 0.6 2.4 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) Amidinotransf PF02274.17 EFO63929.1 - 2.3e-98 329.4 0.0 2.8e-98 329.2 0.0 1.0 1 0 0 1 1 1 1 Amidinotransferase ATG16 PF08614.11 EFO63931.1 - 0.00019 21.7 14.4 0.00019 21.7 14.4 2.8 1 1 2 3 3 2 2 Autophagy protein 16 (ATG16) CCDC144C PF14915.6 EFO63931.1 - 0.00027 20.2 7.9 0.00027 20.2 7.9 2.7 1 1 1 2 2 2 1 CCDC144C protein coiled-coil region ZapB PF06005.12 EFO63931.1 - 0.00028 21.3 40.3 0.0062 17.0 3.7 5.1 2 1 1 3 3 2 2 Cell division protein ZapB KASH_CCD PF14662.6 EFO63931.1 - 0.00067 19.5 34.4 0.027 14.3 19.1 3.1 1 1 2 3 3 3 2 Coiled-coil region of CCDC155 or KASH Leu_zip PF15294.6 EFO63931.1 - 0.0012 18.4 6.7 0.0012 18.4 6.7 3.0 1 1 2 3 3 3 1 Leucine zipper SlyX PF04102.12 EFO63931.1 - 0.0017 18.9 4.3 0.0017 18.9 4.3 5.2 2 2 2 4 4 4 2 SlyX GAT PF03127.14 EFO63931.1 - 0.002 18.4 1.2 0.002 18.4 1.2 3.0 3 2 1 4 4 2 1 GAT domain Wtap PF17098.5 EFO63931.1 - 0.0033 17.4 31.1 0.015 15.2 2.9 3.6 1 1 2 3 3 3 1 WTAP/Mum2p family Med9 PF07544.13 EFO63931.1 - 0.0053 16.8 4.9 0.0053 16.8 4.9 3.4 2 1 2 4 4 3 1 RNA polymerase II transcription mediator complex subunit 9 Mononeg_mRNAcap PF14318.6 EFO63931.1 - 0.011 15.0 0.6 0.02 14.2 0.6 1.4 1 0 0 1 1 1 0 Mononegavirales mRNA-capping region V TolA_bind_tri PF16331.5 EFO63931.1 - 0.012 15.7 5.3 0.012 15.7 5.3 4.4 2 2 1 4 4 4 0 TolA binding protein trimerisation FlxA PF14282.6 EFO63931.1 - 0.018 15.0 13.3 0.018 15.0 13.3 4.0 2 2 1 3 3 3 0 FlxA-like protein DUF4201 PF13870.6 EFO63931.1 - 0.022 14.5 28.5 0.37 10.5 8.2 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) RPW8 PF05659.11 EFO63931.1 - 0.026 14.2 9.8 0.043 13.5 0.3 3.1 1 1 2 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 CENP-F_leu_zip PF10473.9 EFO63931.1 - 0.078 13.0 35.6 0.17 11.9 2.0 3.3 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SPATA24 PF15175.6 EFO63931.1 - 0.14 12.0 19.5 0.33 10.8 10.7 2.7 1 1 1 2 2 2 0 Spermatogenesis-associated protein 24 MAD PF05557.13 EFO63931.1 - 0.2 10.0 28.4 0.32 9.3 14.0 2.9 1 1 1 2 2 2 0 Mitotic checkpoint protein SHE3 PF17078.5 EFO63931.1 - 0.24 11.1 25.0 1.5 8.4 11.1 2.9 1 1 1 3 3 3 0 SWI5-dependent HO expression protein 3 DUF4686 PF15742.5 EFO63931.1 - 0.27 10.3 38.2 0.016 14.4 8.5 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4686) ADIP PF11559.8 EFO63931.1 - 0.34 11.0 40.7 0.14 12.2 6.7 4.0 1 1 4 5 5 5 0 Afadin- and alpha -actinin-Binding HAP1_N PF04849.13 EFO63931.1 - 0.4 9.8 34.7 3.4 6.8 33.5 2.9 1 1 1 2 2 2 0 HAP1 N-terminal conserved region DUF724 PF05266.14 EFO63931.1 - 0.44 10.4 22.4 0.09 12.6 6.1 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF724) FlaC_arch PF05377.11 EFO63931.1 - 0.49 10.8 14.9 2.6 8.5 0.7 5.3 3 2 1 4 4 4 0 Flagella accessory protein C (FlaC) Spc7 PF08317.11 EFO63931.1 - 0.56 9.0 33.2 0.076 11.9 10.0 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein JAKMIP_CC3 PF16034.5 EFO63931.1 - 0.65 9.9 28.5 3.9 7.4 18.2 3.3 1 1 1 2 2 2 0 JAKMIP CC3 domain DUF641 PF04859.12 EFO63931.1 - 0.74 10.2 26.0 0.093 13.1 1.6 4.5 1 1 2 4 4 4 0 Plant protein of unknown function (DUF641) TMF_TATA_bd PF12325.8 EFO63931.1 - 0.76 10.0 33.4 1.6 9.0 2.4 3.7 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF4472 PF14739.6 EFO63931.1 - 0.8 10.5 31.5 3.2 8.5 3.7 4.1 1 1 3 4 4 4 0 Domain of unknown function (DUF4472) LRRFIP PF09738.9 EFO63931.1 - 1 8.8 27.8 0.53 9.7 14.4 2.6 1 1 1 2 2 2 0 LRRFIP family DUF1664 PF07889.12 EFO63931.1 - 1 9.4 18.2 2.3 8.3 0.8 3.4 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) bZIP_1 PF00170.21 EFO63931.1 - 2.6 8.2 22.3 1.3 9.2 0.1 5.4 3 3 2 5 5 5 0 bZIP transcription factor Atg14 PF10186.9 EFO63931.1 - 2.6 7.0 31.3 0.095 11.8 9.3 2.3 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fez1 PF06818.15 EFO63931.1 - 2.8 8.3 29.5 0.51 10.8 13.1 2.2 1 1 1 2 2 2 0 Fez1 G-gamma PF00631.22 EFO63931.1 - 3 7.9 7.4 4.8 7.3 0.8 3.2 1 1 2 3 3 3 0 GGL domain TSC22 PF01166.18 EFO63931.1 - 3.1 8.2 17.1 8.2 6.8 0.4 5.4 2 2 2 5 5 5 0 TSC-22/dip/bun family LapA_dom PF06305.11 EFO63931.1 - 3.5 7.5 5.3 37 4.2 0.4 3.1 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Peptidase_M61 PF05299.12 EFO63931.1 - 3.5 8.0 12.3 10 6.6 0.7 3.5 2 1 2 4 4 3 0 M61 glycyl aminopeptidase Filament PF00038.21 EFO63931.1 - 3.6 7.1 33.0 0.46 10.0 12.2 3.7 1 1 3 4 4 4 0 Intermediate filament protein DUF2046 PF09755.9 EFO63931.1 - 4 6.6 28.6 0.17 11.0 12.0 3.0 1 1 1 3 3 3 0 Uncharacterized conserved protein H4 (DUF2046) Syntaxin-6_N PF09177.11 EFO63931.1 - 4 8.0 19.9 3.8 8.1 1.6 3.4 1 1 2 3 3 3 0 Syntaxin 6, N-terminal DUF4407 PF14362.6 EFO63931.1 - 4.3 6.6 24.9 0.61 9.4 12.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) YabA PF06156.13 EFO63931.1 - 5.2 7.8 26.4 6.4 7.5 6.1 4.3 1 1 2 3 3 3 0 Initiation control protein YabA Fib_alpha PF08702.10 EFO63931.1 - 6.1 7.0 21.1 4 7.6 4.7 3.0 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family Nsp1_C PF05064.13 EFO63931.1 - 6.5 6.6 19.0 0.66 9.8 1.0 4.1 1 1 2 5 5 5 0 Nsp1-like C-terminal region Cnn_1N PF07989.11 EFO63931.1 - 6.7 7.0 21.2 0.2 11.9 0.7 4.5 1 1 3 4 4 4 0 Centrosomin N-terminal motif 1 DUF3450 PF11932.8 EFO63931.1 - 7.6 5.8 35.2 0.22 10.8 3.8 3.4 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) CH_2 PF06294.11 EFO63934.1 - 3.4e-30 104.0 0.0 6.6e-30 103.1 0.0 1.5 1 0 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 EFO63934.1 - 4.7e-12 45.6 0.0 9.2e-12 44.6 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain FAM76 PF16046.5 EFO63934.1 - 0.0012 18.3 0.0 0.0012 18.3 0.0 1.4 2 0 0 2 2 2 1 FAM76 protein CH PF00307.31 EFO63934.1 - 0.0061 16.7 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain DUF730 PF05325.11 EFO63934.1 - 0.24 11.5 0.7 0.42 10.6 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF730) Chibby PF14645.6 EFO63934.1 - 0.43 11.0 4.0 0.39 11.1 1.7 2.0 2 0 0 2 2 2 0 Chibby family Sfi1 PF08457.10 EFO63936.1 - 6.9e-07 28.2 85.8 0.0069 15.0 2.6 7.0 3 2 2 6 6 6 6 Sfi1 spindle body protein DUF1501 PF07394.12 EFO63936.1 - 0.088 11.9 0.4 0.21 10.6 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) PHD_2 PF13831.6 EFO63937.1 - 1.6e-11 43.6 7.5 1.6e-11 43.6 7.5 2.5 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 EFO63937.1 - 1.6e-07 31.1 14.2 1.6e-07 31.1 14.2 3.0 3 0 0 3 3 3 2 PHD-finger zf-PHD-like PF15446.6 EFO63937.1 - 8.7 5.9 19.3 6.6 6.3 9.9 2.4 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain DUF846 PF05832.12 EFO63938.1 - 2.3e-22 79.5 9.2 2.9e-22 79.2 9.2 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) EBP PF05241.12 EFO63938.1 - 0.012 15.0 4.1 0.024 14.1 4.1 1.6 1 1 0 1 1 1 0 Emopamil binding protein LMBR1 PF04791.16 EFO63939.1 - 0.37 9.6 4.4 0.68 8.8 4.4 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein KASH_CCD PF14662.6 EFO63939.1 - 0.38 10.6 31.7 0.011 15.5 7.5 3.3 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH Fungal_trans_2 PF11951.8 EFO63939.1 - 0.46 9.2 5.6 0.57 8.9 4.1 1.8 1 1 0 1 1 1 0 Fungal specific transcription factor domain STAT_alpha PF01017.20 EFO63939.1 - 0.47 10.3 16.8 1.4 8.8 2.9 3.7 4 0 0 4 4 4 0 STAT protein, all-alpha domain Bap31_Bap29_C PF18035.1 EFO63939.1 - 0.53 10.3 8.8 0.77 9.8 4.8 2.7 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF5101 PF17031.5 EFO63939.1 - 1.4 9.1 5.7 0.38 10.9 1.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5101) Tho2 PF11262.8 EFO63939.1 - 2.7 7.1 8.1 2 7.5 2.7 2.6 2 1 1 3 3 3 0 Transcription factor/nuclear export subunit protein 2 ZapA PF05164.13 EFO63939.1 - 3.4 8.2 8.4 8.4 6.9 0.1 3.7 3 0 0 3 3 3 0 Cell division protein ZapA Rootletin PF15035.6 EFO63939.1 - 5.8 6.9 19.3 0.09 12.8 10.0 2.4 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Fez1 PF06818.15 EFO63939.1 - 7.4 7.0 26.8 1.2 9.6 7.9 3.3 2 1 0 3 3 3 0 Fez1 DEAD PF00270.29 EFO63941.1 - 4e-31 108.1 2.8 1.7e-30 106.1 0.0 2.6 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO63941.1 - 6.9e-18 65.0 0.6 2.7e-17 63.1 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFO63941.1 - 4.4e-11 42.9 0.0 1.4e-10 41.2 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) SYF2 PF08231.12 EFO63941.1 - 0.0046 17.4 0.9 0.0046 17.4 0.9 2.5 2 1 0 2 2 2 1 SYF2 splicing factor Ku_PK_bind PF08785.11 EFO63941.1 - 0.01 16.0 4.5 0.018 15.2 1.3 2.6 2 1 0 2 2 2 0 Ku C terminal domain like ResIII PF04851.15 EFO63941.1 - 0.019 14.9 0.1 0.094 12.7 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit UPF0175 PF03683.13 EFO63941.1 - 0.085 12.6 0.2 2 8.2 0.0 2.9 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0175) OsmC PF02566.19 EFO63941.1 - 0.15 12.6 2.0 20 5.8 0.0 3.1 2 1 1 3 3 3 0 OsmC-like protein KORA PF16509.5 EFO63941.1 - 0.18 12.1 1.5 0.52 10.6 1.5 1.8 1 0 0 1 1 1 0 TrfB plasmid transcriptional repressor Ank_2 PF12796.7 EFO63942.1 - 1.2e-56 189.2 13.6 1.4e-13 51.2 0.4 7.1 4 2 3 7 7 7 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63942.1 - 4.6e-36 122.4 12.3 0.00027 21.2 0.0 10.8 5 3 6 11 11 11 9 Ankyrin repeats (many copies) Ank PF00023.30 EFO63942.1 - 1.7e-35 119.9 3.8 0.0026 18.1 0.0 11.3 10 1 1 11 11 11 7 Ankyrin repeat Ank_3 PF13606.6 EFO63942.1 - 6.9e-32 105.9 5.5 0.2 12.3 0.0 11.9 12 0 0 12 12 12 9 Ankyrin repeat Ank_4 PF13637.6 EFO63942.1 - 3.2e-30 104.1 10.3 1.3e-06 28.8 0.1 8.6 9 1 0 9 9 9 6 Ankyrin repeats (many copies) GIT1_C PF12205.8 EFO63942.1 - 0.39 10.9 2.7 23 5.1 0.0 2.6 2 0 0 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term DUF305 PF03713.13 EFO63942.1 - 1.2 9.3 5.2 1.1 9.4 0.3 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF305) GPI-anchored PF10342.9 EFO63943.1 - 1.6e-10 41.6 0.1 1.8e-08 35.0 0.2 2.6 3 0 0 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Trypan_PARP PF05887.11 EFO63943.1 - 0.0013 18.7 8.8 0.0023 17.9 8.8 1.3 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) TonB_N PF16031.5 EFO63943.1 - 0.82 10.2 12.9 1.5 9.3 12.9 1.4 1 0 0 1 1 1 0 TonB polyproline region VSP PF03302.13 EFO63944.1 - 9.1e-88 294.8 173.0 5.8e-43 147.2 33.7 5.1 2 2 3 5 5 5 5 Giardia variant-specific surface protein ANAPC4_WD40 PF12894.7 EFO63945.1 - 0.00082 19.6 0.0 1.1 9.5 0.0 3.8 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFO63945.1 - 0.058 14.3 8.3 0.41 11.6 0.0 5.0 5 1 0 5 5 5 0 WD domain, G-beta repeat Peptidase_C1 PF00112.23 EFO63946.1 - 4.2e-57 193.7 3.4 5.2e-57 193.4 3.4 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFO63946.1 - 8.8e-07 28.0 0.5 0.0011 17.8 0.5 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Arteri_Gl PF00951.18 EFO63948.1 - 0.62 9.9 5.2 0.7 9.7 1.5 2.7 3 0 0 3 3 3 0 Arterivirus GL envelope glycoprotein Chromo PF00385.24 EFO63949.1 - 0.083 12.8 0.3 0.39 10.6 0.0 2.2 2 0 0 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain DUF1246 PF06849.12 EFO63949.1 - 0.088 12.8 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1246) Use1 PF09753.9 EFO63951.1 - 0.00011 22.0 0.5 0.00012 21.9 0.5 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 MCU PF04678.13 EFO63951.1 - 0.13 12.3 1.7 0.16 12.1 1.7 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Ank_2 PF12796.7 EFO63952.1 - 4e-19 69.0 2.9 1.2e-11 45.1 0.3 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO63952.1 - 8.9e-06 25.7 0.4 4.1 8.3 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EFO63952.1 - 5.9e-05 23.3 5.4 0.16 12.5 0.2 4.1 3 1 1 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EFO63952.1 - 0.00044 20.8 0.2 0.097 13.3 0.1 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO63952.1 - 0.0085 16.4 2.1 0.14 12.5 0.4 3.1 2 1 1 3 3 3 1 Ankyrin repeats (many copies) STI1 PF17830.1 EFO63953.1 - 1.3e-29 101.9 19.7 6.7e-16 58.0 1.9 4.5 3 1 1 4 4 4 2 STI1 domain TPR_1 PF00515.28 EFO63953.1 - 8.5e-26 88.7 44.0 6.8e-08 32.0 0.3 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 EFO63953.1 - 3.7e-24 82.8 39.5 7.1e-05 22.6 0.2 9.5 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_12 PF13424.6 EFO63953.1 - 1.7e-16 60.2 24.1 7.2e-05 23.0 0.5 7.5 5 2 2 7 7 7 6 Tetratricopeptide repeat TPR_11 PF13414.6 EFO63953.1 - 3.9e-14 52.0 32.7 7.3e-06 25.6 1.2 8.6 7 2 1 8 8 8 5 TPR repeat TPR_8 PF13181.6 EFO63953.1 - 5.3e-14 51.2 37.3 8.6e-07 28.7 0.2 9.3 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_7 PF13176.6 EFO63953.1 - 3.3e-10 39.3 19.9 0.31 11.2 0.0 8.4 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFO63953.1 - 4.1e-10 40.1 15.8 0.07 13.8 0.2 6.5 6 2 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFO63953.1 - 2.2e-09 37.4 13.5 0.88 10.6 0.1 7.9 6 1 2 8 8 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFO63953.1 - 4.5e-09 36.7 19.4 0.0024 18.3 0.2 6.8 3 3 3 6 6 6 4 Tetratricopeptide repeat TPR_10 PF13374.6 EFO63953.1 - 4.3e-06 26.4 30.0 0.00094 19.0 0.2 9.1 9 1 0 9 9 9 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFO63953.1 - 2.2e-05 24.6 18.7 0.13 12.5 0.3 5.7 5 1 1 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EFO63953.1 - 3.3e-05 24.0 17.9 0.0033 17.7 0.6 6.8 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFO63953.1 - 0.00013 22.1 0.1 0.0035 17.4 0.0 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.18 EFO63953.1 - 0.019 15.0 29.8 0.15 12.2 0.2 6.3 6 1 1 7 7 7 0 MIT (microtubule interacting and transport) domain TPM_phosphatase PF04536.14 EFO63953.1 - 0.037 14.2 1.7 3.1 8.0 0.3 3.3 2 1 0 2 2 2 0 TPM domain HTH_24 PF13412.6 EFO63953.1 - 0.045 13.3 0.5 0.22 11.1 0.0 2.5 3 0 0 3 3 2 0 Winged helix-turn-helix DNA-binding XPC-binding PF09280.11 EFO63953.1 - 0.05 13.3 1.1 2 8.2 0.1 3.0 2 0 0 2 2 2 0 XPC-binding domain malic PF00390.19 EFO63953.1 - 0.08 12.7 0.0 0.32 10.8 0.0 2.0 1 0 0 1 1 1 0 Malic enzyme, N-terminal domain TPR_6 PF13174.6 EFO63953.1 - 0.13 12.9 29.1 3 8.7 0.6 8.5 9 0 0 9 9 8 0 Tetratricopeptide repeat BTAD PF03704.17 EFO63953.1 - 0.4 11.1 11.5 20 5.6 0.1 5.2 4 1 1 5 5 5 0 Bacterial transcriptional activator domain VWA_2 PF13519.6 EFO63953.1 - 0.57 10.9 2.8 1.8 9.2 0.2 2.8 2 1 0 2 2 2 0 von Willebrand factor type A domain GLTP PF08718.11 EFO63953.1 - 4.8 7.4 8.0 15 5.9 0.2 3.0 3 0 0 3 3 3 0 Glycolipid transfer protein (GLTP) Fis1_TPR_C PF14853.6 EFO63953.1 - 5.9 7.0 9.8 7.5 6.7 0.4 3.9 4 0 0 4 4 3 0 Fis1 C-terminal tetratricopeptide repeat APG6_N PF17675.1 EFO63954.1 - 0.054 14.0 2.1 0.085 13.4 2.1 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region bZIP_2 PF07716.15 EFO63954.1 - 0.062 13.4 0.5 0.062 13.4 0.5 3.1 3 1 1 4 4 4 0 Basic region leucine zipper NYD-SP28_assoc PF14775.6 EFO63954.1 - 0.092 12.9 1.2 0.092 12.9 1.2 2.3 1 1 1 2 2 2 0 Sperm tail C-terminal domain Fib_alpha PF08702.10 EFO63954.1 - 0.15 12.2 1.8 0.32 11.2 1.8 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family TSC22 PF01166.18 EFO63954.1 - 0.2 12.0 5.0 0.37 11.1 0.2 3.0 1 1 2 3 3 3 0 TSC-22/dip/bun family ILVD_EDD PF00920.21 EFO63955.1 - 0.012 14.2 0.1 0.018 13.7 0.1 1.2 1 0 0 1 1 1 0 Dehydratase family zf-RING_UBOX PF13445.6 EFO63956.1 - 8.1e-06 25.8 5.8 8.1e-06 25.8 5.8 2.1 1 1 0 1 1 1 1 RING-type zinc-finger TBCA PF02970.16 EFO63956.1 - 0.0088 16.3 9.4 0.01 16.2 3.6 3.2 1 1 1 2 2 2 1 Tubulin binding cofactor A Rootletin PF15035.6 EFO63956.1 - 0.0093 16.0 10.7 0.0093 16.0 10.7 2.3 3 0 0 3 3 3 1 Ciliary rootlet component, centrosome cohesion LCCL PF03815.19 EFO63956.1 - 0.013 15.6 0.1 0.041 14.0 0.1 1.8 1 0 0 1 1 1 0 LCCL domain zf-RING_5 PF14634.6 EFO63956.1 - 0.043 13.8 10.6 0.82 9.7 10.6 2.9 1 1 1 2 2 2 0 zinc-RING finger domain zf-C3HC4 PF00097.25 EFO63956.1 - 0.06 13.2 9.3 0.1 12.5 7.5 2.4 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) YabA PF06156.13 EFO63956.1 - 0.26 11.9 17.3 3.5 8.3 2.7 4.5 3 1 2 5 5 5 0 Initiation control protein YabA Prok-RING_4 PF14447.6 EFO63956.1 - 0.33 10.9 10.3 3.1 7.8 10.6 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 LMBR1 PF04791.16 EFO63956.1 - 0.85 8.5 3.8 1.4 7.8 3.8 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Gin PF10764.9 EFO63956.1 - 1.2 9.1 5.8 26 4.8 0.4 3.5 3 0 0 3 3 3 0 Inhibitor of sigma-G Gin DUF2564 PF10819.8 EFO63956.1 - 1.3 9.5 4.6 11 6.5 1.4 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2564) zf-RING_6 PF14835.6 EFO63956.1 - 3.5 7.6 7.5 1.1 9.2 2.6 2.4 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_2 PF13639.6 EFO63956.1 - 3.7 7.9 15.0 0.43 11.0 4.7 3.0 2 0 0 2 2 2 0 Ring finger domain CREPT PF16566.5 EFO63956.1 - 5.8 7.1 13.6 2.3 8.4 5.6 2.8 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour zf-C3HC4_3 PF13920.6 EFO63956.1 - 8 6.4 17.3 0.025 14.4 5.0 2.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Fzo_mitofusin PF04799.13 EFO63956.1 - 9 5.8 9.0 2.9 7.4 4.5 2.3 1 1 1 2 2 2 0 fzo-like conserved region DUF1664 PF07889.12 EFO63956.1 - 9.4 6.3 8.6 2.7 8.1 1.4 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Ank_2 PF12796.7 EFO63957.1 - 2.8e-10 40.7 0.3 3.6e-06 27.5 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO63957.1 - 5.3e-05 23.7 0.1 0.0022 18.5 0.0 2.5 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO63957.1 - 0.0022 18.3 0.4 0.13 12.6 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) VSP PF03302.13 EFO63958.1 - 6.9e-108 361.0 181.6 2.1e-51 175.0 23.1 6.9 1 1 5 6 6 6 5 Giardia variant-specific surface protein zn-ribbon_14 PF16503.5 EFO63958.1 - 0.0037 16.7 2.6 0.0037 16.7 2.6 9.9 15 1 0 15 15 15 1 Zinc-ribbon Podoplanin PF05808.11 EFO63958.1 - 0.072 13.2 3.1 0.37 10.9 3.1 2.3 1 1 0 1 1 1 0 Podoplanin VSP PF03302.13 EFO63959.1 - 1.3e-39 136.3 179.1 1.6e-30 106.2 60.9 7.6 1 1 4 6 6 6 5 Giardia variant-specific surface protein Kelch_4 PF13418.6 EFO63959.1 - 6.8 6.8 10.9 15 5.7 0.6 3.9 4 0 0 4 4 4 0 Galactose oxidase, central domain VSP PF03302.13 EFO63960.1 - 2.8e-68 230.6 104.4 2.4e-36 125.5 31.4 4.6 1 1 3 4 4 4 3 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO63960.1 - 0.0024 18.0 0.5 0.005 17.0 0.1 1.7 2 0 0 2 2 2 1 Podoplanin Rieske_2 PF13806.6 EFO63960.1 - 0.013 15.5 0.1 5.7 6.9 0.0 2.5 1 1 1 2 2 2 0 Rieske-like [2Fe-2S] domain DUF3449 PF11931.8 EFO63961.1 - 1.7e-19 70.3 2.0 1.9e-19 70.2 0.1 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF3449) zf-C2H2_jaz PF12171.8 EFO63961.1 - 1.7e-05 25.0 2.8 0.0028 17.9 0.3 3.0 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EFO63961.1 - 0.00028 21.1 6.6 0.012 15.9 4.2 2.8 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 EFO63961.1 - 0.0015 18.9 3.2 0.05 14.0 0.7 2.9 2 0 0 2 2 2 1 Zinc-finger of C2H2 type GFA PF04828.14 EFO63961.1 - 0.038 14.3 0.1 2.1 8.7 0.0 2.7 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme UPF1_Zn_bind PF09416.10 EFO63961.1 - 0.04 13.9 4.1 1.9 8.5 1.6 3.1 2 1 1 3 3 3 0 RNA helicase (UPF2 interacting domain) DisA_N PF02457.16 EFO63961.1 - 0.12 12.0 0.8 0.36 10.4 0.6 1.8 1 1 1 2 2 2 0 DisA bacterial checkpoint controller nucleotide-binding SF3A3 PF16837.5 EFO63961.1 - 0.15 12.6 13.9 0.44 11.1 6.3 3.8 3 1 0 3 3 3 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 Ank_2 PF12796.7 EFO63962.1 - 2.4e-40 137.0 2.5 2.2e-10 41.0 0.4 5.7 2 2 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO63962.1 - 7.9e-18 62.7 4.3 0.0083 16.6 0.0 7.8 9 0 0 9 9 7 5 Ankyrin repeat Ank_5 PF13857.6 EFO63962.1 - 3.8e-17 62.1 4.9 0.0022 18.2 0.1 7.2 3 2 4 7 7 7 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO63962.1 - 7.6e-17 61.5 2.1 0.05 14.2 0.0 7.0 5 2 1 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO63962.1 - 5.6e-15 55.0 4.3 0.04 14.4 0.0 7.3 8 1 0 8 8 8 4 Ankyrin repeat IL22 PF14565.6 EFO63962.1 - 0.014 15.7 0.0 0.039 14.2 0.0 1.7 1 0 0 1 1 1 0 Interleukin 22 IL-10-related T-cell-derived-inducible factor Peptidase_C34 PF05413.11 EFO63962.1 - 0.052 13.8 0.1 4.4 7.6 0.0 3.2 3 0 0 3 3 3 0 Putative closterovirus papain-like endopeptidase HIP1_clath_bdg PF16515.5 EFO63962.1 - 2.7 8.7 25.6 2.2 8.9 4.0 4.1 2 1 2 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2508 PF10704.9 EFO63962.1 - 4.3 7.6 10.1 3.5 7.9 1.9 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2508) MPS2 PF17060.5 EFO63962.1 - 8.6 5.5 9.8 6 6.0 5.6 2.2 2 0 0 2 2 2 0 Monopolar spindle protein 2 DUF16 PF01519.16 EFO63962.1 - 9.8 6.7 8.8 26 5.4 5.7 2.7 2 1 0 2 2 2 0 Protein of unknown function DUF16 VSP PF03302.13 EFO63963.1 - 2e-84 283.8 134.8 5e-45 154.0 24.3 3.5 1 1 2 3 3 3 3 Giardia variant-specific surface protein SM-ATX PF14438.6 EFO63963.1 - 0.019 15.1 0.1 0.12 12.5 0.0 2.1 2 0 0 2 2 2 0 Ataxin 2 SM domain Podoplanin PF05808.11 EFO63963.1 - 0.075 13.1 0.2 0.075 13.1 0.2 2.5 2 1 0 2 2 2 0 Podoplanin Ank_2 PF12796.7 EFO63964.1 - 5.4e-32 110.2 0.0 6.9e-15 55.4 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO63964.1 - 2.4e-14 53.2 0.1 0.00061 20.0 0.0 4.3 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63964.1 - 2e-13 49.2 0.0 0.0053 17.2 0.0 5.0 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EFO63964.1 - 5.6e-12 45.9 0.1 5.7e-05 23.6 0.0 3.9 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO63964.1 - 6.4e-12 45.4 0.5 0.061 13.8 0.0 4.7 4 1 1 5 5 5 3 Ankyrin repeat Ank_2 PF12796.7 EFO63965.1 - 8.5e-52 173.7 19.0 4e-10 40.1 0.1 9.1 3 3 6 9 9 9 9 Ankyrin repeats (3 copies) Ank PF00023.30 EFO63965.1 - 5e-27 93.1 15.2 0.00053 20.3 0.1 10.8 10 1 1 11 11 11 6 Ankyrin repeat Ank_4 PF13637.6 EFO63965.1 - 9e-26 89.9 18.0 0.0034 17.9 0.0 10.7 10 2 1 11 11 11 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO63965.1 - 4.3e-25 87.4 19.6 0.021 15.1 0.0 11.2 5 4 7 12 12 12 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO63965.1 - 1.4e-19 68.1 13.3 0.11 13.1 0.0 11.8 14 0 0 14 14 14 4 Ankyrin repeat RC-P840_PscD PF10657.9 EFO63965.1 - 0.028 14.5 0.0 0.057 13.5 0.0 1.4 1 0 0 1 1 1 0 Photosystem P840 reaction centre protein PscD ArfGap PF01412.18 EFO63966.1 - 2.5e-23 82.4 0.2 3.2e-23 82.0 0.2 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf zf-B_box PF00643.24 EFO63966.1 - 0.0014 18.7 1.5 0.0023 18.0 1.5 1.3 1 0 0 1 1 1 1 B-box zinc finger zf-UBP PF02148.19 EFO63966.1 - 0.041 14.2 0.7 0.064 13.6 0.7 1.3 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein Spindle_Spc25 PF08234.12 EFO63967.1 - 1.8e-07 31.3 0.0 4.3e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 GAS PF13851.6 EFO63967.1 - 0.0051 16.2 11.3 0.014 14.7 11.3 1.7 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding Tobravirus_2B PF05271.11 EFO63967.1 - 0.069 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Tobravirus 2B protein DUF4375 PF14300.6 EFO63967.1 - 0.19 12.0 3.6 0.84 9.9 3.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4375) DUF745 PF05335.13 EFO63967.1 - 0.4 10.4 8.3 6.4 6.5 8.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Spc24 PF08286.11 EFO63967.1 - 1.7 8.9 6.9 1.7 8.9 5.8 1.7 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 GrpE PF01025.19 EFO63967.1 - 2.5 7.8 12.2 1.6 8.3 8.8 2.2 1 1 0 2 2 2 0 GrpE SDA1 PF05285.12 EFO63969.1 - 2.8e-18 66.5 48.5 4.1e-17 62.6 38.7 3.1 2 1 0 2 2 2 1 SDA1 DUF2481 PF10654.9 EFO63969.1 - 0.0036 17.3 0.2 0.011 15.7 0.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2481) NUC130_3NT PF08158.12 EFO63969.1 - 0.022 15.1 0.1 0.07 13.5 0.1 1.9 1 0 0 1 1 1 0 NUC130/3NT domain Ndc80_HEC PF03801.13 EFO63969.1 - 0.033 13.8 0.3 0.084 12.5 0.3 1.7 1 0 0 1 1 1 0 HEC/Ndc80p family EF-hand_7 PF13499.6 EFO63970.1 - 7.6e-33 112.8 2.3 5.1e-16 58.9 1.0 2.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFO63970.1 - 1.1e-32 109.1 5.2 9.2e-09 34.2 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EFO63970.1 - 3.4e-28 97.2 8.0 9.1e-11 41.4 0.1 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 EFO63970.1 - 2.6e-26 89.3 5.3 1.8e-08 33.7 0.1 4.6 3 1 1 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EFO63970.1 - 6.4e-21 72.8 5.8 4.2e-06 26.0 0.0 4.5 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 EFO63970.1 - 2.1e-13 50.4 0.1 1.6e-05 25.1 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EFO63970.1 - 5.7e-07 29.8 0.0 0.028 14.7 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 EFO63970.1 - 9.3e-05 22.5 6.3 0.035 14.3 0.6 2.8 1 1 2 3 3 3 3 Dockerin type I domain EF-hand_4 PF12763.7 EFO63970.1 - 0.00011 22.1 0.1 0.11 12.5 0.1 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EFhand_Ca_insen PF08726.10 EFO63970.1 - 0.00023 21.2 0.1 0.0015 18.6 0.0 2.1 2 0 0 2 2 2 1 Ca2+ insensitive EF hand DUF5580 PF17743.1 EFO63970.1 - 0.0019 16.8 0.0 0.002 16.7 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) Caleosin PF05042.13 EFO63970.1 - 0.0034 17.3 0.1 0.81 9.6 0.0 2.8 1 1 1 3 3 3 1 Caleosin related protein UPF0154 PF03672.13 EFO63970.1 - 0.02 14.9 0.0 0.12 12.5 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) TerB PF05099.13 EFO63970.1 - 0.025 14.5 0.0 2.7 7.9 0.0 2.2 2 0 0 2 2 2 0 Tellurite resistance protein TerB EF-hand_11 PF08976.11 EFO63970.1 - 0.03 15.2 0.0 0.062 14.2 0.0 1.6 1 1 0 1 1 1 0 EF-hand domain Ribosomal_S27 PF01599.19 EFO63971.1 - 3.1e-12 46.5 6.3 5.4e-12 45.7 6.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S27a OrfB_Zn_ribbon PF07282.11 EFO63971.1 - 0.041 13.8 1.3 0.072 13.0 1.3 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Auto_anti-p27 PF06677.12 EFO63971.1 - 0.59 10.3 4.2 1 9.6 4.2 1.4 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-Paramyx-P PF13008.7 EFO63971.1 - 3.5 7.2 7.2 0.3 10.6 2.6 1.6 2 0 0 2 2 2 0 Zinc-binding domain of Paramyxoviridae V protein FadA PF09403.10 EFO63972.1 - 0.0054 17.2 7.6 0.0093 16.4 5.1 2.1 1 1 1 2 2 2 1 Adhesion protein FadA BshC PF10079.9 EFO63972.1 - 0.018 13.8 3.5 0.024 13.4 3.5 1.1 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC Med30 PF11315.8 EFO63972.1 - 0.055 13.7 4.4 0.078 13.2 4.4 1.2 1 0 0 1 1 1 0 Mediator complex subunit 30 Seryl_tRNA_N PF02403.22 EFO63972.1 - 0.41 10.9 7.0 0.86 9.9 7.1 1.6 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain FAM76 PF16046.5 EFO63972.1 - 0.6 9.4 5.1 0.79 9.0 5.1 1.1 1 0 0 1 1 1 0 FAM76 protein Hydrolase_4 PF12146.8 EFO63973.1 - 9e-13 48.0 0.1 1.5e-09 37.5 0.2 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFO63973.1 - 0.00011 21.9 0.1 0.00026 20.7 0.1 1.6 1 1 1 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFO63973.1 - 0.00012 21.6 0.1 0.0063 16.0 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family FSH1 PF03959.13 EFO63973.1 - 0.0058 16.3 0.0 0.009 15.7 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DUF818 PF05677.12 EFO63973.1 - 0.007 15.4 0.1 0.011 14.7 0.1 1.3 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Cutinase PF01083.22 EFO63973.1 - 0.011 15.7 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 0 Cutinase DUF1749 PF08538.10 EFO63973.1 - 0.023 13.8 0.0 0.033 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) LIP PF03583.14 EFO63973.1 - 0.025 13.9 0.7 2 7.7 0.0 2.3 1 1 1 2 2 2 0 Secretory lipase DUF4422 PF14393.6 EFO63973.1 - 0.038 13.8 1.5 0.14 12.0 0.5 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4422) Abhydrolase_2 PF02230.16 EFO63973.1 - 0.11 12.3 0.3 0.36 10.6 0.3 1.9 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase Clat_adaptor_s PF01217.20 EFO63974.1 - 6.1e-50 168.8 5.5 6.8e-50 168.7 5.5 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Steroid_dh PF02544.16 EFO63975.1 - 3e-22 79.2 1.2 3e-22 79.2 1.2 2.9 2 1 1 3 3 3 1 3-oxo-5-alpha-steroid 4-dehydrogenase VSP PF03302.13 EFO63977.1 - 3e-98 329.3 101.1 1.6e-49 168.9 48.7 3.2 1 1 2 3 3 3 3 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO63977.1 - 0.018 15.2 1.9 0.018 15.2 1.9 6.9 1 1 6 7 7 7 0 Furin-like repeat, cysteine-rich Podoplanin PF05808.11 EFO63977.1 - 0.022 14.8 0.5 0.041 14.0 0.1 1.6 2 0 0 2 2 2 0 Podoplanin SecE PF00584.20 EFO63978.1 - 0.00051 19.9 0.0 0.00061 19.7 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex CENP-F_leu_zip PF10473.9 EFO63980.1 - 0.0016 18.5 6.1 0.0016 18.5 6.1 3.1 3 0 0 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HALZ PF02183.18 EFO63980.1 - 0.012 15.8 2.5 0.055 13.7 2.5 2.2 1 0 0 1 1 1 0 Homeobox associated leucine zipper Tup_N PF08581.10 EFO63980.1 - 0.027 14.7 5.2 0.24 11.7 5.0 2.8 2 0 0 2 2 2 0 Tup N-terminal Adaptin_N PF01602.20 EFO63983.1 - 2e-37 129.0 10.8 2.9e-37 128.5 10.8 1.2 1 0 0 1 1 1 1 Adaptin N terminal region HHH_2 PF12826.7 EFO63984.1 - 0.029 14.4 0.0 0.058 13.5 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif HHH PF00633.23 EFO63984.1 - 0.045 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif 5_3_exonuc PF01367.20 EFO63984.1 - 0.16 12.6 0.0 0.46 11.1 0.0 1.7 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold Flu_NS2 PF00601.19 EFO63986.1 - 0.1 12.9 0.7 0.17 12.2 0.7 1.3 1 0 0 1 1 1 0 Influenza non-structural protein (NS2) Peptidase_C1 PF00112.23 EFO63987.1 - 2.3e-40 139.0 3.6 3.6e-40 138.4 3.6 1.2 1 0 0 1 1 1 1 Papain family cysteine protease GPI-anchored PF10342.9 EFO63987.1 - 4.4e-12 46.6 0.2 6e-08 33.3 0.2 3.8 3 0 0 3 3 3 2 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Trypan_PARP PF05887.11 EFO63987.1 - 0.006 16.6 8.8 0.006 16.6 8.8 2.9 3 0 0 3 3 3 1 Procyclic acidic repetitive protein (PARP) TonB_N PF16031.5 EFO63987.1 - 9.9 6.7 16.3 1.4 9.4 11.3 2.1 2 0 0 2 2 2 0 TonB polyproline region VSP PF03302.13 EFO63988.1 - 9.4e-71 238.7 132.9 1.4e-47 162.4 26.5 3.9 1 1 2 3 3 3 2 Giardia variant-specific surface protein Spc7 PF08317.11 EFO63990.1 - 3.8e-07 29.3 23.2 3.8e-06 26.0 6.5 9.8 7 2 3 10 10 10 6 Spc7 kinetochore protein KASH_CCD PF14662.6 EFO63990.1 - 9.3e-05 22.3 10.5 9.3e-05 22.3 10.5 10.3 6 4 3 10 10 10 3 Coiled-coil region of CCDC155 or KASH ERM PF00769.19 EFO63990.1 - 0.00045 20.1 9.7 0.00045 20.1 9.7 9.2 4 3 4 9 9 9 3 Ezrin/radixin/moesin family Fez1 PF06818.15 EFO63990.1 - 0.00052 20.5 107.3 0.25 11.8 6.2 8.7 2 2 5 8 8 8 7 Fez1 Atg14 PF10186.9 EFO63990.1 - 0.00069 18.8 3.3 0.00069 18.8 3.3 8.1 6 2 1 7 7 7 3 Vacuolar sorting 38 and autophagy-related subunit 14 ADIP PF11559.8 EFO63990.1 - 0.0057 16.7 9.2 0.0057 16.7 9.2 12.7 7 3 8 15 15 15 2 Afadin- and alpha -actinin-Binding TMF_DNA_bd PF12329.8 EFO63990.1 - 0.016 15.2 1.2 0.016 15.2 1.2 17.4 14 5 3 17 17 17 0 TATA element modulatory factor 1 DNA binding SlyX PF04102.12 EFO63990.1 - 0.17 12.5 0.1 0.17 12.5 0.1 17.2 14 4 4 18 18 18 0 SlyX Spidroin_N PF16763.5 EFO63990.1 - 1.5 8.8 15.2 0.13 12.3 0.8 4.2 4 0 0 4 4 4 0 Major ampullate spidroin 1, spider silk protein 1, N-term RdRP PF05183.12 EFO63991.1 - 4.6e-86 289.8 0.0 9.8e-86 288.6 0.0 1.5 1 0 0 1 1 1 1 RNA dependent RNA polymerase Annexin_like PF18411.1 EFO63991.1 - 0.084 13.1 1.4 15 5.9 0.2 3.0 2 0 0 2 2 2 0 Annexin-like domain GLTP PF08718.11 EFO63992.1 - 0.12 12.6 0.1 0.45 10.8 0.0 1.9 2 0 0 2 2 2 0 Glycolipid transfer protein (GLTP) ATP-grasp_5 PF13549.6 EFO63993.1 - 4.6e-62 209.4 0.0 7.2e-62 208.7 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 EFO63993.1 - 1e-21 77.2 0.0 9.7e-21 74.0 0.0 2.3 1 1 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EFO63993.1 - 2.8e-06 27.8 0.0 7.2e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain ATP-grasp_2 PF08442.10 EFO63993.1 - 0.0048 16.5 0.0 0.0086 15.6 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain CoA_binding PF02629.19 EFO63993.1 - 0.1 13.3 0.1 0.77 10.5 0.1 2.6 1 1 1 2 2 2 0 CoA binding domain Kinesin PF00225.23 EFO63996.1 - 5.7e-84 281.9 0.3 5.7e-84 281.9 0.3 2.2 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EFO63996.1 - 7.6e-24 84.3 0.0 2.4e-23 82.7 0.0 1.9 1 0 0 1 1 1 1 Microtubule binding PAC3 PF10178.9 EFO63997.1 - 0.023 14.8 0.0 0.043 14.0 0.0 1.5 1 0 0 1 1 1 0 Proteasome assembly chaperone 3 Peptidase_M49 PF03571.15 EFO63998.1 - 6.8e-142 473.7 0.0 8.8e-142 473.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M49 AhpC-TSA PF00578.21 EFO64000.1 - 3.9e-12 46.2 0.0 6.5e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin PF00085.20 EFO64000.1 - 1.2e-10 41.2 0.1 1.1e-08 35.0 0.1 2.2 1 1 1 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.6 EFO64000.1 - 3e-09 37.1 0.0 5.5e-09 36.2 0.0 1.5 2 0 0 2 2 2 1 Thioredoxin-like Redoxin PF08534.10 EFO64000.1 - 3.5e-07 30.0 0.0 5e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Redoxin Thioredoxin_2 PF13098.6 EFO64000.1 - 0.00045 20.6 0.0 0.0007 20.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 EFO64000.1 - 0.014 15.2 0.1 0.024 14.4 0.1 1.5 1 1 0 1 1 1 0 Thioredoxin Exo84_C PF16528.5 EFO64001.1 - 0.023 14.5 1.7 2.2 8.0 0.1 2.1 2 0 0 2 2 2 0 Exocyst component 84 C-terminal ProRS-C_2 PF09181.10 EFO64001.1 - 0.14 12.3 0.2 0.27 11.4 0.2 1.5 1 0 0 1 1 1 0 Prolyl-tRNA synthetase, C-terminal Lipase_3 PF01764.25 EFO64002.1 - 1.4e-09 37.9 0.0 1.1e-08 35.0 0.0 2.4 1 1 0 1 1 1 1 Lipase (class 3) FANCL_C PF11793.8 EFO64002.1 - 0.043 14.0 0.9 0.12 12.6 0.9 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain VSP PF03302.13 EFO64003.1 - 8.3e-13 47.9 58.7 3.1e-09 36.2 8.4 3.0 1 1 2 3 3 3 3 Giardia variant-specific surface protein DIM PF08194.12 EFO64003.1 - 0.068 13.4 0.7 0.068 13.4 0.7 4.3 4 0 0 4 4 4 0 DIM protein Ank_2 PF12796.7 EFO64004.1 - 9.6e-84 276.1 3.9 4.9e-19 68.7 0.1 6.5 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64004.1 - 1.4e-52 175.4 11.3 4e-10 40.0 0.5 8.8 5 2 4 10 10 10 8 Ankyrin repeats (many copies) Ank PF00023.30 EFO64004.1 - 3.1e-47 157.0 0.8 0.0043 17.4 0.0 11.7 11 0 0 11 11 11 10 Ankyrin repeat Ank_5 PF13857.6 EFO64004.1 - 1.4e-46 155.9 13.6 6.3e-06 26.4 0.0 10.4 1 1 9 10 10 10 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64004.1 - 1.6e-41 135.5 0.8 0.01 16.3 0.0 11.9 12 0 0 12 12 12 9 Ankyrin repeat Pkinase PF00069.25 EFO64004.1 - 4.6e-17 62.2 0.0 2.1e-16 60.1 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64004.1 - 3.6e-12 46.1 0.0 6.2e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SinI PF08671.10 EFO64004.1 - 0.0078 16.0 0.5 39 4.2 0.0 5.1 5 0 0 5 5 5 0 Anti-repressor SinI T3SSipB PF16535.5 EFO64004.1 - 0.98 9.9 3.6 1.7 9.1 3.6 1.3 1 0 0 1 1 1 0 Type III cell invasion protein SipB Ank_2 PF12796.7 EFO64006.1 - 5.5e-60 199.9 1.0 2.4e-13 50.5 0.0 6.6 1 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64006.1 - 9.6e-33 111.2 6.9 0.00024 21.4 0.0 11.0 11 1 1 12 12 11 7 Ankyrin repeat Ank_4 PF13637.6 EFO64006.1 - 7.6e-32 109.3 9.4 0.00048 20.6 0.0 10.8 8 3 4 12 12 11 7 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO64006.1 - 5.8e-30 104.5 0.0 1.2e-29 103.6 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Ank_3 PF13606.6 EFO64006.1 - 1.1e-29 99.2 4.1 0.009 16.5 0.0 11.6 11 0 0 11 11 11 5 Ankyrin repeat Ank_5 PF13857.6 EFO64006.1 - 2.5e-27 94.6 16.8 0.00019 21.6 0.1 10.9 4 3 9 13 13 13 9 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO64006.1 - 2.1e-17 63.3 0.0 3e-17 62.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Tropomyosin PF00261.20 EFO64006.1 - 0.00036 20.0 2.8 0.00066 19.1 2.8 1.3 1 0 0 1 1 1 1 Tropomyosin SlyX PF04102.12 EFO64006.1 - 0.0013 19.3 1.3 1.3 9.7 0.1 2.6 1 1 1 2 2 2 2 SlyX Tropomyosin_1 PF12718.7 EFO64006.1 - 0.0021 18.2 0.5 0.0039 17.3 0.5 1.4 1 0 0 1 1 1 1 Tropomyosin like Sugarporin_N PF11471.8 EFO64006.1 - 0.0032 17.4 4.5 0.0032 17.4 4.5 2.9 2 1 0 2 2 2 1 Maltoporin periplasmic N-terminal extension APH PF01636.23 EFO64006.1 - 0.0034 17.4 0.1 0.0034 17.4 0.1 2.7 3 0 0 3 3 3 1 Phosphotransferase enzyme family MscS_porin PF12795.7 EFO64006.1 - 0.0039 16.8 3.6 0.0048 16.5 1.2 2.0 1 1 1 2 2 2 1 Mechanosensitive ion channel porin domain CENP-F_leu_zip PF10473.9 EFO64006.1 - 0.0062 16.6 1.2 0.012 15.6 1.2 1.4 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Kinase-like PF14531.6 EFO64006.1 - 0.0077 15.6 0.0 0.12 11.7 0.0 2.6 3 0 0 3 3 3 1 Kinase-like JIP_LZII PF16471.5 EFO64006.1 - 0.048 13.8 0.3 0.14 12.3 0.3 1.8 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II ABC_tran_CTD PF16326.5 EFO64006.1 - 0.053 13.8 4.4 0.65 10.3 0.2 2.8 1 1 1 2 2 2 0 ABC transporter C-terminal domain DUF4763 PF15960.5 EFO64006.1 - 0.096 12.0 0.1 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Spc7 PF08317.11 EFO64006.1 - 0.14 11.0 0.6 0.24 10.3 0.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4140 PF13600.6 EFO64006.1 - 0.41 11.1 2.1 29 5.2 0.5 2.8 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) RVT_1 PF00078.27 EFO64007.1 - 3.7e-11 43.0 0.0 6.9e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.6 EFO64007.1 - 2.2e-05 24.9 7.7 0.83 10.7 0.0 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFO64007.1 - 7e-05 23.0 1.9 0.11 12.8 0.1 3.1 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFO64007.1 - 9.5e-05 22.7 3.5 0.57 10.7 0.0 3.4 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_9 PF16293.5 EFO64007.1 - 0.011 15.5 6.6 0.038 13.8 0.1 3.2 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-C2H2 PF00096.26 EFO64007.1 - 0.013 15.9 10.3 1.4 9.5 0.0 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EFO64007.1 - 0.022 15.1 4.0 15 6.0 0.1 3.4 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 EFO64007.1 - 0.038 13.8 6.8 0.1 12.4 1.1 2.7 3 0 0 3 3 3 0 zinc-finger C2H2-type Zn-C2H2_12 PF18112.1 EFO64007.1 - 0.06 13.8 1.9 9.3 6.8 0.1 3.1 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain GAGA PF09237.11 EFO64007.1 - 0.71 9.7 10.6 1.5 8.7 1.0 3.2 3 0 0 3 3 3 0 GAGA factor zf-Di19 PF05605.12 EFO64007.1 - 1.5 9.2 8.8 18 5.8 0.1 3.4 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Ank_2 PF12796.7 EFO64008.1 - 1.2e-49 166.8 0.0 3.6e-13 49.9 0.0 5.5 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64008.1 - 1.6e-32 111.5 0.3 1.1e-05 25.9 0.0 8.5 6 3 2 8 8 8 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO64008.1 - 2.9e-30 103.4 0.5 0.00098 19.5 0.0 9.2 9 0 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 EFO64008.1 - 4.8e-24 84.1 8.2 0.00077 19.7 0.1 8.4 3 2 4 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64008.1 - 1.7e-21 74.0 1.4 0.053 14.1 0.0 8.7 8 2 1 9 9 9 5 Ankyrin repeat Phage_T7_Capsid PF05396.11 EFO64008.1 - 0.19 12.1 0.0 0.41 11.0 0.0 1.5 1 0 0 1 1 1 0 Phage T7 capsid assembly protein HemY_N PF07219.13 EFO64008.1 - 0.33 11.1 2.9 0.21 11.8 0.4 1.9 2 0 0 2 2 2 0 HemY protein N-terminus RVT_1 PF00078.27 EFO64009.1 - 1.3e-13 51.0 0.0 2.1e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GATase PF00117.28 EFO64011.1 - 2.3e-33 115.6 0.0 5.3e-33 114.4 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CTP_synth_N PF06418.14 EFO64011.1 - 1.1e-11 44.6 0.0 2e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 CTP synthase N-terminus Peptidase_C26 PF07722.13 EFO64011.1 - 1.4e-06 28.2 0.3 0.00016 21.5 0.2 3.1 1 1 1 2 2 2 1 Peptidase C26 RecR PF02132.15 EFO64011.1 - 0.33 10.5 1.9 1.1 8.9 1.9 1.9 1 0 0 1 1 1 0 RecR protein EMP24_GP25L PF01105.24 EFO64012.1 - 5.1e-19 68.9 0.0 6.4e-19 68.6 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD UCH PF00443.29 EFO64013.1 - 6.7e-42 143.7 1.2 8e-42 143.5 1.2 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFO64013.1 - 4.2e-07 29.9 4.7 6.5e-06 26.0 4.7 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ATG16 PF08614.11 EFO64017.1 - 0.028 14.6 6.9 0.069 13.4 6.9 1.6 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF4391 PF14335.6 EFO64017.1 - 0.044 13.5 1.0 0.098 12.3 1.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) MetOD2 PF18548.1 EFO64017.1 - 0.14 12.3 2.0 0.6 10.3 2.0 2.2 1 0 0 1 1 1 0 Metanogen output domain 2 DUF4140 PF13600.6 EFO64017.1 - 0.29 11.6 3.5 0.72 10.3 3.5 1.7 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Pox_A_type_inc PF04508.12 EFO64017.1 - 1.3 9.0 4.4 23 5.1 0.3 2.9 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat DUF1644 PF07800.12 EFO64018.1 - 0.045 13.8 0.3 0.07 13.2 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1644) Plasmo_rep PF12135.8 EFO64020.1 - 0.88 9.2 7.8 8.1 6.1 0.4 4.8 4 1 0 4 4 4 0 Plasmodium repeat family Ank_2 PF12796.7 EFO64021.1 - 4.6e-58 193.8 19.8 3.7e-11 43.5 0.5 7.5 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO64021.1 - 1.3e-35 117.4 5.2 0.0029 18.0 0.0 12.4 12 0 0 12 12 12 8 Ankyrin repeat Ank_4 PF13637.6 EFO64021.1 - 2.3e-34 117.3 6.3 2.1e-07 31.3 0.0 9.8 8 2 1 10 10 9 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO64021.1 - 2.8e-28 97.1 6.8 0.0003 21.1 0.0 11.1 10 1 1 11 11 11 6 Ankyrin repeat Ank_5 PF13857.6 EFO64021.1 - 1.1e-26 92.5 12.8 0.00039 20.7 0.0 8.8 2 2 7 10 10 10 8 Ankyrin repeats (many copies) T6SS_VipA PF05591.12 EFO64021.1 - 0.017 15.0 0.6 0.065 13.0 0.6 2.1 1 0 0 1 1 1 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 Unpaired PF15972.5 EFO64021.1 - 0.027 14.0 0.2 0.077 12.5 0.2 1.7 1 0 0 1 1 1 0 Unpaired protein Spheroidin PF05541.12 EFO64021.1 - 0.12 10.2 0.3 0.17 9.7 0.3 1.1 1 0 0 1 1 1 0 Entomopoxvirus spheroidin protein SlyX PF04102.12 EFO64021.1 - 0.14 12.8 4.0 2.1 9.0 0.0 3.5 3 0 0 3 3 3 0 SlyX Sec20 PF03908.13 EFO64021.1 - 1.5 8.8 4.1 3.2 7.7 0.1 3.7 4 0 0 4 4 4 0 Sec20 DUF4200 PF13863.6 EFO64021.1 - 2.7 8.4 8.6 2.5 8.5 1.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) LRR_6 PF13516.6 EFO64022.1 - 8.4e-06 25.4 11.1 0.23 11.6 0.0 5.1 5 0 0 5 5 5 4 Leucine Rich repeat LRR_1 PF00560.33 EFO64022.1 - 0.00025 21.2 9.1 1.3 9.9 0.2 5.4 4 1 0 4 4 4 2 Leucine Rich Repeat LRR_4 PF12799.7 EFO64022.1 - 0.001 19.4 5.2 0.5 10.9 0.1 3.7 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) NTP_transf_2 PF01909.23 EFO64023.1 - 0.0025 18.1 0.0 0.0044 17.3 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain PUB_1 PF18486.1 EFO64025.1 - 0.0043 16.9 0.1 0.014 15.2 0.1 1.9 1 0 0 1 1 1 1 PNGase/UBA- or UBX-containing domain OST-HTH PF12872.7 EFO64025.1 - 0.023 14.5 0.0 0.051 13.4 0.0 1.5 1 0 0 1 1 1 0 OST-HTH/LOTUS domain DUF4974 PF16344.5 EFO64025.1 - 0.097 12.7 0.0 0.32 11.0 0.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4974) Thioredoxin_6 PF13848.6 EFO64027.1 - 1e-33 116.8 2.1 2.4e-31 109.1 1.2 2.5 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin PF00085.20 EFO64027.1 - 1.1e-31 108.8 0.2 2.6e-31 107.7 0.2 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EFO64027.1 - 0.0013 19.0 0.1 0.37 11.1 0.0 3.2 2 2 1 3 3 3 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EFO64027.1 - 0.0016 18.8 0.8 0.017 15.5 0.2 2.8 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EFO64027.1 - 0.0018 18.4 0.0 0.013 15.7 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin-like TraF PF13728.6 EFO64027.1 - 0.08 12.7 0.1 0.17 11.7 0.0 1.5 2 0 0 2 2 2 0 F plasmid transfer operon protein Redoxin PF08534.10 EFO64027.1 - 0.096 12.4 0.1 0.31 10.7 0.1 1.8 2 0 0 2 2 2 0 Redoxin Thioredoxin_9 PF14595.6 EFO64027.1 - 0.13 12.1 0.0 0.3 10.8 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin PseudoU_synth_1 PF01416.20 EFO64028.1 - 3.6e-09 37.1 0.0 2.3e-07 31.2 0.0 2.4 2 0 0 2 2 2 1 tRNA pseudouridine synthase NAPRTase_C PF17956.1 EFO64028.1 - 0.059 13.8 0.3 0.38 11.2 0.0 2.2 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase C-terminal domain CAF1 PF04857.20 EFO64029.1 - 8.4e-27 94.2 0.0 2e-26 92.9 0.0 1.5 1 1 0 1 1 1 1 CAF1 family ribonuclease MORN PF02493.20 EFO64031.1 - 1.3e-07 31.1 18.1 0.0062 16.4 0.2 6.0 6 0 0 6 6 6 4 MORN repeat Peptidase_S3 PF00944.19 EFO64031.1 - 0.022 14.6 0.1 0.1 12.4 0.1 1.9 2 0 0 2 2 2 0 Alphavirus core protein 53-BP1_Tudor PF09038.10 EFO64031.1 - 0.2 11.6 2.4 6.4 6.8 0.5 2.6 1 1 2 3 3 3 0 Tumour suppressor p53-binding protein-1 Tudor MT PF12777.7 EFO64032.1 - 0.022 13.8 5.9 1.9 7.4 2.2 2.4 2 0 0 2 2 2 0 Microtubule-binding stalk of dynein motor HBD PF18534.1 EFO64032.1 - 0.058 13.5 0.0 0.27 11.4 0.0 2.2 1 0 0 1 1 1 0 Helical bundle domain Fe-ADH PF00465.19 EFO64033.1 - 1.4e-103 346.5 0.2 2.3e-103 345.8 0.2 1.3 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Aldedh PF00171.22 EFO64033.1 - 2.7e-27 95.4 2.3 6.2e-27 94.2 2.3 1.5 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Fe-ADH_2 PF13685.6 EFO64033.1 - 1.3e-12 48.0 3.5 2.6e-06 27.4 0.0 2.7 3 0 0 3 3 3 2 Iron-containing alcohol dehydrogenase Lactamase_B_6 PF16661.5 EFO64035.1 - 3.6e-06 26.6 0.1 7.7e-06 25.5 0.1 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 EFO64035.1 - 0.0025 17.8 0.2 0.0058 16.7 0.1 1.6 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily LRRNT_2 PF08263.12 EFO64036.1 - 1.2e-06 28.7 1.5 2.4e-06 27.7 1.5 1.6 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_8 PF13855.6 EFO64036.1 - 9.7e-06 25.3 0.4 0.19 11.5 0.1 3.0 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 EFO64036.1 - 0.00078 19.8 4.0 0.2 12.1 0.5 3.6 2 1 1 4 4 4 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFO64036.1 - 0.011 16.2 3.0 2.5 9.0 0.2 3.9 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_6 PF13516.6 EFO64036.1 - 0.24 11.6 1.7 6.7 7.0 0.1 3.4 3 0 0 3 3 3 0 Leucine Rich repeat SNF2_N PF00176.23 EFO64037.1 - 3.5e-48 164.1 0.0 1.8e-37 128.9 0.0 2.4 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EFO64037.1 - 1.7e-16 60.5 0.1 7.3e-16 58.5 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 EFO64037.1 - 2.1e-10 40.5 0.2 5.7e-10 39.1 0.2 1.7 1 0 0 1 1 1 1 Bromodomain ResIII PF04851.15 EFO64037.1 - 4.9e-05 23.4 0.0 0.00017 21.6 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EFO64037.1 - 0.0033 16.6 0.4 0.0093 15.2 0.4 1.7 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 AAA_11 PF13086.6 EFO64037.1 - 0.0094 15.8 0.0 0.032 14.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain VESA1_N PF12785.7 EFO64037.1 - 0.11 11.4 0.5 0.19 10.6 0.5 1.3 1 0 0 1 1 1 0 Variant erythrocyte surface antigen-1 TB2_DP1_HVA22 PF03134.19 EFO64038.1 - 6.2e-12 45.3 3.0 9.5e-12 44.7 3.0 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Cullin_Nedd8 PF10557.9 EFO64039.1 - 0.0016 18.5 1.5 0.005 16.9 0.4 2.4 2 0 0 2 2 2 1 Cullin protein neddylation domain DUF4490 PF14892.6 EFO64041.1 - 1.5e-11 44.3 3.0 2.6e-09 37.1 0.6 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4490) NepR PF18557.1 EFO64041.1 - 0.04 13.6 0.0 0.055 13.1 0.0 1.2 1 0 0 1 1 1 0 Anti-sigma factor NepR bZIP_1 PF00170.21 EFO64043.1 - 0.00042 20.3 0.2 0.00042 20.3 0.2 2.9 3 1 1 4 4 4 1 bZIP transcription factor NBP1 PF08537.10 EFO64043.1 - 0.035 13.5 2.3 0.046 13.2 2.0 1.5 1 1 0 1 1 1 0 Fungal Nap binding protein NBP1 PspA_IM30 PF04012.12 EFO64043.1 - 0.04 13.5 0.6 0.06 12.9 0.6 1.2 1 0 0 1 1 1 0 PspA/IM30 family ATG16 PF08614.11 EFO64043.1 - 0.05 13.8 1.5 0.05 13.8 1.5 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Tropomyosin PF00261.20 EFO64043.1 - 0.05 13.0 1.9 0.1 11.9 1.9 1.4 1 1 0 1 1 1 0 Tropomyosin CENP-F_leu_zip PF10473.9 EFO64043.1 - 0.077 13.0 2.4 0.13 12.3 2.4 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMPIT PF07851.13 EFO64043.1 - 0.11 11.7 1.4 0.16 11.2 1.4 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF3450 PF11932.8 EFO64043.1 - 0.19 11.0 2.0 0.5 9.6 1.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) NPV_P10 PF05531.12 EFO64043.1 - 0.59 10.6 6.7 1.2 9.7 1.5 3.0 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.12 EFO64043.1 - 7.4 7.3 8.5 18 6.1 1.3 2.8 2 1 1 3 3 3 0 SlyX Prenyltransf PF01255.19 EFO64044.1 - 7.8e-09 35.4 0.0 1.1e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase DUF5079 PF16882.5 EFO64044.1 - 0.0062 16.4 0.1 0.0062 16.4 0.1 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF5079) Pkinase PF00069.25 EFO64046.1 - 8.1e-05 22.1 0.0 9.8e-05 21.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64046.1 - 0.00011 21.7 0.0 0.00012 21.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO64048.1 - 1e-58 195.8 3.2 1.7e-14 54.2 0.0 4.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64048.1 - 7.3e-35 117.9 3.4 0.00035 20.9 0.0 9.0 9 0 0 9 9 9 6 Ankyrin repeat Ank_4 PF13637.6 EFO64048.1 - 1.2e-34 118.2 2.9 1.7e-07 31.6 0.0 6.4 5 1 2 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64048.1 - 4.4e-33 109.6 1.1 0.011 16.2 0.0 9.5 9 0 0 9 9 9 7 Ankyrin repeat Ank_5 PF13857.6 EFO64048.1 - 3.9e-29 100.3 8.8 1.3e-05 25.3 0.0 8.0 1 1 7 8 8 8 7 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO64048.1 - 2.8e-21 76.0 0.0 9.5e-21 74.3 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64048.1 - 2.8e-15 56.3 0.0 4.2e-15 55.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2894 PF11445.8 EFO64048.1 - 1.5 9.3 6.0 2.8 8.4 6.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) DUF4129 PF13559.6 EFO64048.1 - 3.4 8.0 10.0 8.5e+02 0.3 9.7 4.7 4 2 1 5 5 5 0 Domain of unknown function (DUF4129) PX PF00787.24 EFO64050.1 - 8.7e-14 51.5 1.2 1.5e-13 50.7 1.2 1.3 1 0 0 1 1 1 1 PX domain PRK PF00485.18 EFO64051.1 - 5e-16 59.0 0.1 5.3e-15 55.7 0.1 2.2 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family SRP54 PF00448.22 EFO64051.1 - 0.0013 18.4 0.0 0.0027 17.4 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_14 PF13173.6 EFO64051.1 - 0.003 17.6 0.0 0.012 15.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EFO64051.1 - 0.004 16.9 0.0 0.0076 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFO64051.1 - 0.0046 17.1 0.0 0.0091 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EFO64051.1 - 0.012 15.5 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea APS_kinase PF01583.20 EFO64051.1 - 0.017 15.0 0.0 0.039 13.9 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase KTI12 PF08433.10 EFO64051.1 - 0.018 14.5 0.1 0.074 12.5 0.0 1.9 2 0 0 2 2 2 0 Chromatin associated protein KTI12 ATPase PF06745.13 EFO64051.1 - 0.022 14.1 0.1 0.056 12.8 0.0 1.6 2 0 0 2 2 2 0 KaiC NTPase_1 PF03266.15 EFO64051.1 - 0.046 13.6 0.1 0.23 11.3 0.0 2.1 2 0 0 2 2 2 0 NTPase CbiA PF01656.23 EFO64051.1 - 0.048 13.7 0.0 0.12 12.4 0.0 1.8 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain NACHT PF05729.12 EFO64051.1 - 0.051 13.5 0.0 0.34 10.8 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.6 EFO64051.1 - 0.07 13.7 0.0 0.16 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EFO64051.1 - 0.084 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein ArsA_ATPase PF02374.15 EFO64051.1 - 0.11 11.7 0.3 0.29 10.3 0.0 1.9 2 0 0 2 2 2 0 Anion-transporting ATPase AAA_28 PF13521.6 EFO64051.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EFO64051.1 - 0.13 11.3 0.1 0.54 9.3 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 EFO64051.1 - 0.14 11.4 0.0 0.3 10.4 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.6 EFO64051.1 - 0.15 12.4 0.0 0.34 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Pkinase PF00069.25 EFO64052.1 - 5.4e-71 239.0 0.0 7.9e-71 238.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64052.1 - 3.7e-40 137.9 0.0 7.1e-40 136.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFO64052.1 - 1.5e-06 27.4 1.1 2.2e-06 26.9 1.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EFO64052.1 - 0.0017 18.0 0.7 0.0028 17.3 0.7 1.2 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 EFO64052.1 - 0.0088 15.4 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFO64052.1 - 0.049 13.0 0.0 0.086 12.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EFO64052.1 - 0.069 12.7 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase SprA-related PF12118.8 EFO64053.1 - 3.5 6.7 6.5 5.3 6.1 6.5 1.2 1 0 0 1 1 1 0 SprA-related family ATG16 PF08614.11 EFO64054.1 - 0.0046 17.2 13.4 0.0046 17.2 13.4 4.7 3 1 1 4 4 4 1 Autophagy protein 16 (ATG16) Imm7 PF15585.6 EFO64054.1 - 0.12 12.7 6.7 5.6 7.3 0.5 4.0 4 0 0 4 4 4 0 Immunity protein 7 Striatin PF08232.12 EFO64054.1 - 0.49 11.0 0.0 0.49 11.0 0.0 4.7 4 1 1 5 5 5 0 Striatin family DUF5638 PF18688.1 EFO64054.1 - 0.65 10.3 6.8 0.4 11.0 0.8 3.8 3 1 0 3 3 3 0 Family of unknown function (DUF5638) DUF2935 PF11155.8 EFO64054.1 - 5.3 7.4 7.8 14 6.1 0.5 4.1 2 2 1 3 3 3 0 Domain of unknown function (DUF2935) EVE PF01878.18 EFO64055.1 - 7.6e-06 26.0 0.0 1.1e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 EVE domain GHMP_kinases_N PF00288.26 EFO64056.1 - 2.5e-05 24.4 0.3 8.7e-05 22.7 0.3 2.0 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EFO64056.1 - 5.7e-05 23.4 0.0 0.00013 22.3 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal Uso1_p115_C PF04871.13 EFO64056.1 - 0.53 10.7 1.7 0.82 10.0 1.7 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region zf-CCCH PF00642.24 EFO64057.1 - 0.0031 17.4 16.7 0.12 12.4 7.4 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EFO64057.1 - 0.058 14.1 6.9 2.3 9.0 1.4 2.4 2 1 0 2 2 2 0 Torus domain RRM_1 PF00076.22 EFO64057.1 - 0.089 12.6 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 EFO64057.1 - 1.7 8.8 18.5 1.5 9.0 10.3 2.6 2 0 0 2 2 2 0 Zinc finger domain CD24 PF14984.6 EFO64058.1 - 0.11 12.7 3.4 0.34 11.2 3.4 1.9 1 0 0 1 1 1 0 CD24 protein MORN PF02493.20 EFO64059.1 - 0.0023 17.7 2.6 5.4 7.1 0.8 5.4 5 0 0 5 5 5 1 MORN repeat Ank_2 PF12796.7 EFO64060.1 - 7.9e-109 356.5 42.6 1.5e-14 54.3 0.3 11.0 2 2 10 12 12 12 12 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64060.1 - 3.2e-59 196.2 30.0 2.8e-05 24.3 0.1 16.5 4 2 12 16 16 16 15 Ankyrin repeats (many copies) Ank PF00023.30 EFO64060.1 - 8.3e-57 187.3 28.3 4e-06 27.0 0.0 19.6 17 2 3 20 20 20 14 Ankyrin repeat Ank_4 PF13637.6 EFO64060.1 - 3e-53 177.5 29.5 1.3e-08 35.2 0.1 14.9 7 5 11 18 18 18 15 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64060.1 - 1.1e-52 169.8 26.5 3.5e-05 23.9 0.0 20.9 20 1 1 21 21 21 10 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO64060.1 - 5.6e-08 32.5 10.9 1e-07 31.7 10.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO64060.1 - 0.0013 18.5 12.2 0.0029 17.4 12.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFO64060.1 - 0.25 11.7 15.7 0.16 12.3 13.5 1.9 2 0 0 2 2 2 0 Ring finger domain zf-RING_5 PF14634.6 EFO64060.1 - 1 9.3 11.5 2.2 8.3 11.5 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFO64061.1 - 6.7e-07 29.1 50.7 3.4e-06 26.8 9.1 3.7 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFO64061.1 - 4.6e-05 23.3 9.0 4.6e-05 23.3 9.0 3.8 3 0 0 3 3 3 2 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFO64061.1 - 0.00016 21.4 11.0 0.00016 21.4 11.0 3.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EFO64061.1 - 0.00029 20.6 35.9 0.0011 18.8 3.5 3.8 3 0 0 3 3 3 3 zf-RING of BARD1-type protein zf-C3HC4 PF00097.25 EFO64061.1 - 0.00046 20.0 10.0 0.00046 20.0 10.0 3.7 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFO64061.1 - 0.00054 19.9 8.6 0.00054 19.9 8.6 4.4 3 1 1 4 4 4 2 RING-type zinc-finger zf-RING_2 PF13639.6 EFO64061.1 - 0.002 18.5 11.6 0.002 18.5 11.6 3.8 3 0 0 3 3 3 1 Ring finger domain zf-MIZ PF02891.20 EFO64061.1 - 0.0042 16.8 9.9 0.0042 16.8 9.9 3.6 3 0 0 3 3 3 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EFO64061.1 - 0.59 10.0 7.6 1.6 8.6 7.6 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.6 EFO64061.1 - 5.5 7.2 50.8 0.24 11.6 9.5 3.8 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING EGF_2 PF07974.13 EFO64062.1 - 6.6e-05 23.2 359.5 0.0003 21.1 8.5 29.3 28 1 0 28 28 28 20 EGF-like domain Laminin_EGF PF00053.24 EFO64062.1 - 0.0012 19.0 16.5 0.0012 19.0 16.5 22.0 20 5 6 26 26 26 5 Laminin EGF domain VSP PF03302.13 EFO64063.1 - 1.1e-65 222.1 126.7 5e-44 150.8 28.2 3.6 1 1 2 3 3 3 3 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO64063.1 - 0.12 12.5 1.8 0.3 11.2 1.8 1.6 1 0 0 1 1 1 0 Podoplanin Furin-like_2 PF15913.5 EFO64063.1 - 0.23 11.6 88.5 0.1 12.8 10.8 7.2 1 1 5 7 7 7 0 Furin-like repeat, cysteine-rich SKG6 PF08693.10 EFO64063.1 - 0.34 10.4 4.5 0.56 9.7 4.5 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain RIBIOP_C PF04950.12 EFO64064.1 - 4.9e-67 226.4 0.1 4.9e-67 226.4 0.1 2.2 3 0 0 3 3 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EFO64064.1 - 6.8e-18 64.6 0.0 2.4e-17 62.8 0.0 2.0 1 0 0 1 1 1 1 AARP2CN (NUC121) domain AAA_28 PF13521.6 EFO64064.1 - 0.0065 16.7 5.1 0.096 12.9 0.5 3.6 3 0 0 3 3 3 1 AAA domain GTP_EFTU PF00009.27 EFO64064.1 - 0.0071 15.9 1.2 2.3 7.7 0.0 3.0 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 EFO64064.1 - 0.0088 16.2 0.0 0.025 14.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFO64064.1 - 0.016 15.6 0.1 0.09 13.2 0.1 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EFO64064.1 - 0.025 14.6 0.0 0.063 13.3 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 EFO64064.1 - 0.032 14.5 0.0 0.085 13.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFO64064.1 - 0.04 14.4 0.0 0.04 14.4 0.0 3.3 3 0 0 3 3 3 0 ABC transporter MMR_HSR1 PF01926.23 EFO64064.1 - 0.042 13.9 2.1 0.046 13.8 0.2 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_16 PF13191.6 EFO64064.1 - 0.075 13.4 0.1 0.34 11.3 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 EFO64064.1 - 0.14 12.5 0.0 0.5 10.8 0.0 2.0 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 EFO64064.1 - 0.81 9.7 3.2 0.71 9.9 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFO64064.1 - 2.1 8.9 7.9 0.1 13.1 0.7 2.7 3 0 0 3 3 1 0 AAA domain Ank_2 PF12796.7 EFO64065.1 - 4.7e-54 180.9 14.7 2.8e-15 56.7 0.2 5.6 2 1 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64065.1 - 2.5e-31 107.3 17.3 3.2e-07 30.5 0.1 10.3 4 2 7 11 11 11 10 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64065.1 - 4.3e-28 97.3 5.9 2.1e-07 31.3 0.2 7.3 5 2 3 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64065.1 - 7.7e-28 93.5 14.4 0.026 15.1 0.0 11.6 11 0 0 11 11 11 6 Ankyrin repeat Ank PF00023.30 EFO64065.1 - 8.1e-27 92.5 22.3 0.00051 20.4 0.2 11.4 8 3 2 10 10 10 8 Ankyrin repeat Pkinase PF00069.25 EFO64065.1 - 1.4e-17 63.9 0.0 6.5e-17 61.8 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64065.1 - 2.4e-06 27.1 0.0 1.1e-05 24.8 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase CdAMP_rec PF06153.11 EFO64065.1 - 0.0061 16.8 0.1 0.6 10.3 0.0 3.0 2 1 0 2 2 2 1 Cyclic-di-AMP receptor mRNA_cap_enzyme PF01331.19 EFO64066.1 - 1.8e-22 80.1 0.0 3.6e-14 53.1 0.0 2.5 2 1 0 2 2 2 2 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EFO64066.1 - 1.1e-07 32.4 0.1 4.2e-07 30.6 0.1 2.1 1 1 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 EFO64066.1 - 0.00063 19.5 0.0 0.0019 17.9 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase domain cNMP_binding PF00027.29 EFO64068.1 - 5.1e-10 39.3 0.1 0.00031 20.7 0.0 3.3 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain NMT PF01233.19 EFO64070.1 - 8e-46 155.8 0.0 6e-44 149.7 0.0 2.2 2 0 0 2 2 2 2 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.15 EFO64070.1 - 6.6e-25 87.9 0.8 1.2e-24 87.1 0.8 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_1 PF00583.25 EFO64070.1 - 0.038 14.2 0.0 0.25 11.6 0.0 2.2 2 1 0 2 2 2 0 Acetyltransferase (GNAT) family Pro-kuma_activ PF09286.11 EFO64071.1 - 0.038 14.3 0.2 0.077 13.3 0.2 1.4 1 0 0 1 1 1 0 Pro-kumamolisin, activation domain Cnd1 PF12717.7 EFO64072.1 - 0.014 15.5 3.5 2.2 8.3 0.2 3.2 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFO64072.1 - 0.68 10.4 5.4 6.2 7.4 0.1 4.6 4 0 0 4 4 4 0 HEAT repeat Dus PF01207.17 EFO64073.1 - 2.2e-12 46.7 0.0 1.1e-11 44.4 0.0 2.2 2 1 1 3 3 3 1 Dihydrouridine synthase (Dus) Ank_2 PF12796.7 EFO64074.1 - 2.2e-68 226.8 32.9 2e-09 37.9 0.5 14.3 8 4 6 14 14 14 14 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO64074.1 - 7.6e-33 108.8 30.1 0.13 12.9 0.5 21.7 22 0 0 22 22 22 6 Ankyrin repeat Ank_5 PF13857.6 EFO64074.1 - 1.9e-29 101.3 32.2 7.6e-06 26.1 0.1 16.8 14 5 4 18 18 18 9 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64074.1 - 1.7e-24 85.9 18.5 2.1e-05 25.0 0.4 12.7 10 4 1 11 11 11 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO64074.1 - 5.5e-23 80.3 32.2 0.34 11.4 0.0 18.7 20 0 0 20 20 20 7 Ankyrin repeat DnaGprimase_HBD PF16730.5 EFO64075.1 - 0.095 12.8 1.5 6.1 7.0 0.1 3.0 3 1 0 3 3 3 0 DnaG-primase C-terminal, helicase-binding domain Wtap PF17098.5 EFO64076.1 - 0.0055 16.6 0.5 0.0067 16.4 0.5 1.2 1 0 0 1 1 1 1 WTAP/Mum2p family Cortex-I_coil PF09304.10 EFO64077.1 - 0.0061 16.8 0.8 0.0086 16.3 0.8 1.2 1 0 0 1 1 1 1 Cortexillin I, coiled coil Snf7 PF03357.21 EFO64077.1 - 0.0066 16.1 0.7 0.0083 15.7 0.7 1.1 1 0 0 1 1 1 1 Snf7 CAMSAP_CC1 PF17095.5 EFO64077.1 - 0.16 11.9 3.1 0.26 11.2 3.1 1.3 1 0 0 1 1 1 0 Spectrin-binding region of Ca2+-Calmodulin Biopterin_H PF00351.21 EFO64078.1 - 0.02 14.0 0.0 0.035 13.2 0.0 1.3 1 0 0 1 1 1 0 Biopterin-dependent aromatic amino acid hydroxylase Synaptobrevin PF00957.21 EFO64080.1 - 0.022 14.6 3.4 1.4 8.8 0.0 3.1 3 0 0 3 3 3 0 Synaptobrevin TSNAXIP1_N PF15739.5 EFO64080.1 - 0.2 12.0 1.8 16 5.9 0.2 2.9 2 1 0 2 2 2 0 Translin-associated factor X-interacting N-terminus EzrA PF06160.12 EFO64080.1 - 0.27 9.4 6.0 0.13 10.4 1.0 2.2 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA JIP_LZII PF16471.5 EFO64080.1 - 0.27 11.4 1.7 0.77 10.0 0.5 2.4 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II APG6_N PF17675.1 EFO64080.1 - 1.1 9.7 7.4 0.94 10.0 0.8 2.4 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF4164 PF13747.6 EFO64080.1 - 7 7.0 6.9 4.9 7.5 0.4 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4164) ABC_tran PF00005.27 EFO64081.1 - 3.9e-24 85.7 0.0 7.9e-24 84.7 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFO64081.1 - 4.3e-06 26.3 0.0 0.00033 20.1 0.0 2.0 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EFO64081.1 - 0.00012 22.2 0.3 0.0004 20.4 0.1 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFO64081.1 - 0.00014 21.9 0.4 0.00036 20.5 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EFO64081.1 - 0.00032 21.1 0.1 0.00086 19.7 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFO64081.1 - 0.0023 18.2 0.2 0.028 14.7 0.2 2.5 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EFO64081.1 - 0.0041 16.8 0.1 0.0091 15.7 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_24 PF13479.6 EFO64081.1 - 0.016 14.9 0.1 1.1 8.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EFO64081.1 - 0.018 15.5 0.1 1 9.8 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 EFO64081.1 - 0.026 14.4 0.0 0.8 9.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system ATP-synt_ab PF00006.25 EFO64081.1 - 0.032 13.9 0.3 0.41 10.3 0.1 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain GBP PF02263.19 EFO64081.1 - 0.033 13.5 0.3 0.21 10.8 0.1 2.3 3 0 0 3 3 3 0 Guanylate-binding protein, N-terminal domain Roc PF08477.13 EFO64081.1 - 0.039 14.2 0.0 0.12 12.6 0.0 1.9 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 EFO64081.1 - 0.041 14.4 0.0 0.097 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EFO64081.1 - 0.05 13.3 0.2 1.2 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EFO64081.1 - 0.14 12.2 0.0 3.2 7.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) FeoB_N PF02421.18 EFO64081.1 - 0.16 11.5 0.4 0.56 9.7 0.1 1.9 2 0 0 2 2 2 0 Ferrous iron transport protein B Ins134_P3_kin PF05770.11 EFO64082.1 - 0.17 11.4 0.0 0.2 11.1 0.0 1.1 1 0 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain Sulfatase PF00884.23 EFO64083.1 - 8.6e-15 54.9 0.0 1.3e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EFO64083.1 - 0.0033 17.1 0.0 0.028 14.0 0.0 2.0 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Collectrin PF16959.5 EFO64083.1 - 0.021 14.6 5.4 0.026 14.3 2.8 2.2 2 0 0 2 2 2 0 Renal amino acid transporter DUF1678 PF07913.11 EFO64083.1 - 0.087 12.6 0.1 0.16 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1678) LapA_dom PF06305.11 EFO64083.1 - 0.5 10.2 7.9 1.9 8.4 0.1 3.6 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain DUF676 PF05057.14 EFO64084.1 - 8.6e-08 31.9 0.0 1.6e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EFO64084.1 - 0.0022 17.9 0.0 0.0039 17.1 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 EFO64084.1 - 0.017 14.9 0.0 0.038 13.7 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_1 PF00561.20 EFO64084.1 - 0.018 14.7 0.0 0.07 12.8 0.0 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 EFO64084.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) DUF3437 PF11919.8 EFO64086.1 - 0.00012 21.9 0.1 0.00037 20.3 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) FtsJ PF01728.19 EFO64088.1 - 1.9e-65 220.3 0.0 2.3e-65 220.0 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase RRM_1 PF00076.22 EFO64089.1 - 5.1e-13 48.6 0.0 8.1e-13 48.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFO64089.1 - 0.0023 17.9 0.1 0.0039 17.2 0.1 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Snurportin1 PF11538.8 EFO64089.1 - 0.047 13.9 0.2 0.12 12.6 0.2 1.6 1 0 0 1 1 1 0 Snurportin1 NAD_kinase PF01513.21 EFO64090.1 - 2.1e-47 161.7 0.0 4e-47 160.8 0.0 1.4 1 1 0 1 1 1 1 ATP-NAD kinase Ank_2 PF12796.7 EFO64091.1 - 1.4e-09 38.4 0.0 0.00052 20.5 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO64091.1 - 1.3e-07 31.3 0.2 0.0057 17.1 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 EFO64091.1 - 5.9e-06 26.7 0.1 0.03 14.9 0.1 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO64091.1 - 6.7e-06 26.3 0.6 0.015 15.7 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EFO64091.1 - 2.9e-05 24.3 0.1 0.063 13.6 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) RRXRR PF14239.6 EFO64091.1 - 0.21 11.5 0.0 0.29 11.0 0.0 1.1 1 0 0 1 1 1 0 RRXRR protein Kinesin PF00225.23 EFO64092.1 - 7.4e-105 350.5 2.5 7.4e-105 350.5 2.5 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFO64092.1 - 2.8e-26 92.2 0.0 1.4e-25 90.0 0.0 2.2 2 0 0 2 2 2 1 Microtubule binding bZIP_1 PF00170.21 EFO64092.1 - 0.0056 16.7 0.9 0.023 14.8 0.1 2.4 2 0 0 2 2 2 1 bZIP transcription factor Occludin_ELL PF07303.13 EFO64092.1 - 0.018 15.8 0.9 0.2 12.4 0.1 2.8 2 0 0 2 2 2 0 Occludin homology domain bZIP_2 PF07716.15 EFO64092.1 - 0.024 14.7 2.0 0.038 14.1 0.6 2.2 2 0 0 2 2 2 0 Basic region leucine zipper TPALS PF18178.1 EFO64092.1 - 0.079 12.4 0.1 0.15 11.5 0.1 1.4 1 0 0 1 1 1 0 TIR- and PNP-associating SLOG family DUF1192 PF06698.11 EFO64092.1 - 0.27 11.3 2.9 0.54 10.4 0.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) JIP_LZII PF16471.5 EFO64092.1 - 2.2 8.5 9.2 0.41 10.8 0.1 3.5 4 0 0 4 4 4 0 JNK-interacting protein leucine zipper II HALZ PF02183.18 EFO64092.1 - 2.5 8.4 5.9 0.32 11.2 0.2 2.6 4 0 0 4 4 4 0 Homeobox associated leucine zipper TSC22 PF01166.18 EFO64092.1 - 2.8 8.3 7.8 5.7 7.3 0.3 3.9 4 0 0 4 4 4 0 TSC-22/dip/bun family FlaC_arch PF05377.11 EFO64092.1 - 3.2 8.2 7.3 58 4.2 0.3 4.2 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Med9 PF07544.13 EFO64092.1 - 4.5 7.4 8.5 14 5.9 0.5 3.7 4 0 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 Atg14 PF10186.9 EFO64092.1 - 7.9 5.5 19.7 0.095 11.8 6.9 3.0 2 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA PF00004.29 EFO64093.1 - 1.5e-14 54.6 0.0 2.3e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EFO64093.1 - 2.4e-12 46.9 0.0 1.3e-10 41.3 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 EFO64093.1 - 5.1e-08 33.2 0.1 1.4e-06 28.6 0.0 2.7 3 0 0 3 3 2 1 Replication factor C C-terminal domain AAA_22 PF13401.6 EFO64093.1 - 9.7e-07 29.1 0.2 2.6e-05 24.5 0.2 2.7 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFO64093.1 - 3.3e-06 27.6 0.2 1.5e-05 25.5 0.2 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 EFO64093.1 - 1.4e-05 24.9 0.0 2.2e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFO64093.1 - 3.5e-05 23.6 0.1 8.5e-05 22.4 0.1 1.8 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 EFO64093.1 - 6.7e-05 22.9 0.0 0.0002 21.3 0.0 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain Viral_helicase1 PF01443.18 EFO64093.1 - 8.8e-05 22.4 0.0 0.00013 21.8 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.14 EFO64093.1 - 9.8e-05 22.4 0.0 0.00038 20.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EFO64093.1 - 0.00012 21.9 0.0 0.00051 19.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFO64093.1 - 0.00019 21.6 0.0 0.00033 20.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EFO64093.1 - 0.00022 20.8 0.0 0.00051 19.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_14 PF13173.6 EFO64093.1 - 0.0004 20.4 0.0 0.0011 19.0 0.0 1.6 2 0 0 2 2 1 1 AAA domain DUF815 PF05673.13 EFO64093.1 - 0.00052 19.2 0.0 0.00092 18.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 EFO64093.1 - 0.00068 19.1 0.1 0.016 14.6 0.1 2.1 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EFO64093.1 - 0.00081 19.9 0.0 0.0013 19.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EFO64093.1 - 0.001 19.5 0.0 0.0018 18.7 0.0 1.4 1 0 0 1 1 1 1 RNA helicase AAA_11 PF13086.6 EFO64093.1 - 0.0016 18.3 0.5 0.071 12.9 0.0 2.1 1 1 1 2 2 2 1 AAA domain ResIII PF04851.15 EFO64093.1 - 0.0039 17.2 0.2 1.6 8.7 0.0 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EFO64093.1 - 0.0045 17.3 0.4 0.099 13.0 0.4 2.4 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 EFO64093.1 - 0.0051 16.7 0.0 0.034 14.1 0.0 2.1 1 1 0 1 1 1 1 NACHT domain ATPase_2 PF01637.18 EFO64093.1 - 0.0059 16.5 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea TniB PF05621.11 EFO64093.1 - 0.0077 15.7 0.1 0.52 9.7 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein NTPase_1 PF03266.15 EFO64093.1 - 0.0085 16.0 0.0 0.19 11.7 0.1 2.2 2 0 0 2 2 2 1 NTPase AAA_3 PF07726.11 EFO64093.1 - 0.0093 15.8 0.0 0.025 14.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_assoc_2 PF16193.5 EFO64093.1 - 0.012 15.9 0.2 0.037 14.4 0.1 1.9 2 0 0 2 2 1 0 AAA C-terminal domain MMR_HSR1 PF01926.23 EFO64093.1 - 0.016 15.3 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase KTI12 PF08433.10 EFO64093.1 - 0.019 14.5 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 MCM PF00493.23 EFO64093.1 - 0.025 13.7 0.0 0.048 12.7 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain DEAD PF00270.29 EFO64093.1 - 0.026 14.3 0.7 0.13 12.0 0.1 2.1 1 1 1 2 2 2 0 DEAD/DEAH box helicase DUF2075 PF09848.9 EFO64093.1 - 0.029 13.6 0.4 0.18 11.0 0.2 2.1 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_2 PF07724.14 EFO64093.1 - 0.029 14.5 0.0 0.066 13.3 0.0 1.6 2 0 0 2 2 1 0 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 EFO64093.1 - 0.031 14.5 0.0 0.062 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFO64093.1 - 0.032 14.7 0.1 0.065 13.8 0.1 1.6 1 1 0 1 1 1 0 ABC transporter MeaB PF03308.16 EFO64093.1 - 0.035 13.1 0.1 0.11 11.5 0.0 1.9 2 1 1 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 EFO64093.1 - 0.039 13.9 0.0 0.064 13.2 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 EFO64093.1 - 0.04 13.7 0.0 0.073 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 EFO64093.1 - 0.041 13.1 0.0 0.065 12.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain TsaE PF02367.17 EFO64093.1 - 0.057 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 EFO64093.1 - 0.065 13.7 0.0 0.093 13.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EFO64093.1 - 0.068 12.5 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Bac_DnaA PF00308.18 EFO64093.1 - 0.068 13.0 0.0 0.24 11.2 0.0 1.8 2 0 0 2 2 2 0 Bacterial dnaA protein AAA_6 PF12774.7 EFO64093.1 - 0.07 12.1 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region Torsin PF06309.11 EFO64093.1 - 0.079 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Torsin MobB PF03205.14 EFO64093.1 - 0.08 12.8 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B TrwB_AAD_bind PF10412.9 EFO64093.1 - 0.092 11.6 0.0 0.17 10.7 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Roc PF08477.13 EFO64093.1 - 0.095 12.9 0.1 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EFO64093.1 - 0.17 11.6 0.1 0.41 10.4 0.1 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_10 PF12846.7 EFO64093.1 - 0.23 10.3 0.9 14 4.5 0.0 2.6 2 1 0 3 3 3 0 AAA-like domain Pkinase PF00069.25 EFO64094.1 - 6e-31 107.8 0.0 1.1e-30 107.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EFO64094.1 - 6.3e-26 90.8 3.3 7e-10 39.4 0.1 4.8 3 1 2 5 5 5 4 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EFO64094.1 - 1.5e-20 73.6 0.0 8.8e-20 71.1 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Ank_5 PF13857.6 EFO64094.1 - 9.5e-16 57.7 2.4 0.00018 21.7 0.0 6.4 4 2 2 7 7 7 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO64094.1 - 5.6e-15 55.0 1.9 0.16 12.4 0.0 6.7 5 1 1 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 EFO64094.1 - 9.2e-15 53.3 3.8 0.46 11.2 0.1 6.7 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 EFO64094.1 - 8.3e-13 48.6 0.2 0.00093 19.7 0.0 5.6 3 1 3 6 6 6 3 Ankyrin repeats (many copies) Kinase-like PF14531.6 EFO64094.1 - 2.3e-05 23.9 0.0 3.8e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Ank_2 PF12796.7 EFO64095.1 - 8e-52 173.8 5.5 3.8e-15 56.2 0.1 5.6 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64095.1 - 2.1e-31 107.0 8.8 0.0014 19.0 0.0 8.2 8 0 0 8 8 8 6 Ankyrin repeat Ank_3 PF13606.6 EFO64095.1 - 2.5e-30 101.1 6.8 0.02 15.4 0.0 9.6 9 0 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 EFO64095.1 - 7.5e-27 93.1 10.4 3e-05 24.2 0.2 7.4 2 2 5 7 7 7 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64095.1 - 6.6e-25 87.2 9.3 1.6e-05 25.3 0.1 6.6 6 0 0 6 6 6 5 Ankyrin repeats (many copies) zf-C3HC4_3 PF13920.6 EFO64095.1 - 1.3e-11 44.2 9.7 1.3e-11 44.2 9.7 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO64095.1 - 2.6e-07 30.4 6.5 5.2e-07 29.4 6.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Spc7 PF08317.11 EFO64095.1 - 0.00054 18.9 2.5 0.00085 18.3 2.5 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein zf-C3HC4_2 PF13923.6 EFO64095.1 - 0.0013 18.5 8.7 0.0031 17.3 8.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) LRS4 PF10422.9 EFO64095.1 - 0.0014 18.3 1.7 0.0029 17.2 1.7 1.4 1 0 0 1 1 1 1 Monopolin complex subunit LRS4 zf-RING_2 PF13639.6 EFO64095.1 - 0.0019 18.5 10.1 0.0019 18.5 10.1 2.1 2 0 0 2 2 2 1 Ring finger domain FPP PF05911.11 EFO64095.1 - 0.0026 16.0 3.7 0.0033 15.7 3.7 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil ROS_MUCR PF05443.11 EFO64095.1 - 0.0056 16.7 0.9 0.012 15.6 0.9 1.5 1 0 0 1 1 1 1 ROS/MUCR transcriptional regulator protein TACC_C PF05010.14 EFO64095.1 - 0.007 16.2 1.1 0.015 15.1 1.1 1.4 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ATG16 PF08614.11 EFO64095.1 - 0.0091 16.2 6.9 0.017 15.3 6.9 1.4 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF724 PF05266.14 EFO64095.1 - 0.041 13.7 2.7 0.068 13.0 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) BST2 PF16716.5 EFO64095.1 - 0.044 14.4 7.6 0.12 12.9 7.6 1.8 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 DUF2009 PF09418.10 EFO64095.1 - 0.055 12.5 0.4 0.093 11.8 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) Mt_ATP_synt PF15704.5 EFO64095.1 - 0.11 12.4 3.2 14 5.6 0.0 3.5 4 0 0 4 4 3 0 Mitochondrial ATP synthase subunit ADIP PF11559.8 EFO64095.1 - 0.14 12.2 7.8 0.28 11.2 7.8 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding zf-RING_5 PF14634.6 EFO64095.1 - 0.14 12.1 8.9 0.32 11.0 8.9 1.6 1 0 0 1 1 1 0 zinc-RING finger domain Lzipper-MIP1 PF14389.6 EFO64095.1 - 0.32 11.3 6.2 0.4 11.0 1.3 2.5 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 DUF641 PF04859.12 EFO64095.1 - 0.33 11.3 5.8 2.3 8.6 1.6 2.6 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Exonuc_VII_L PF02601.15 EFO64095.1 - 0.42 10.1 5.0 0.71 9.4 5.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit XkdW PF09636.10 EFO64095.1 - 0.45 10.6 2.8 3.3 7.8 1.2 2.3 2 0 0 2 2 2 0 XkdW protein DUF1043 PF06295.12 EFO64095.1 - 0.46 10.5 4.2 1 9.4 4.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Rad50_zn_hook PF04423.14 EFO64095.1 - 0.64 9.9 3.6 9.8 6.1 0.7 2.6 2 0 0 2 2 2 0 Rad50 zinc hook motif APG6_N PF17675.1 EFO64095.1 - 0.67 10.5 7.6 0.27 11.8 4.9 1.7 2 0 0 2 2 1 0 Apg6 coiled-coil region DUF4404 PF14357.6 EFO64095.1 - 1.4 9.6 7.6 3.5 8.3 3.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) mCpol PF18182.1 EFO64095.1 - 2.3 8.6 6.0 29 5.1 0.1 3.9 5 1 0 5 5 3 0 minimal CRISPR polymerase domain DivIC PF04977.15 EFO64095.1 - 2.7 7.8 8.6 0.32 10.8 1.9 2.2 1 1 1 2 2 2 0 Septum formation initiator Fungal_TACC PF12709.7 EFO64095.1 - 2.9 8.4 6.8 18 5.9 6.9 2.2 1 1 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins Csm1_N PF18504.1 EFO64095.1 - 5.1 7.5 8.6 2.6 8.4 2.8 2.4 1 1 1 2 2 2 0 Csm1 N-terminal domain Pribosyltran PF00156.27 EFO64096.1 - 8.9e-08 31.8 0.0 1.3e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain AAA_19 PF13245.6 EFO64096.1 - 0.025 14.9 0.1 0.034 14.5 0.1 1.2 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 EFO64096.1 - 0.029 13.9 0.0 0.033 13.7 0.0 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain PRTase_2 PF15609.6 EFO64096.1 - 0.051 13.1 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosyl transferase LRR_9 PF14580.6 EFO64097.1 - 4.9e-09 35.9 9.2 9.1e-09 35.1 3.7 3.1 2 1 1 3 3 3 1 Leucine-rich repeat LRR_4 PF12799.7 EFO64097.1 - 4.5e-07 30.1 19.6 0.0016 18.8 1.0 4.5 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO64097.1 - 0.00018 21.2 15.2 0.0042 16.8 1.6 3.7 1 1 3 4 4 4 4 Leucine rich repeat LRR_6 PF13516.6 EFO64097.1 - 0.0079 16.2 2.3 7.5 6.9 0.1 3.8 3 0 0 3 3 3 2 Leucine Rich repeat T3SS_HrpK1 PF16937.5 EFO64097.1 - 0.032 13.9 2.5 1.2 8.8 0.2 2.5 2 0 0 2 2 2 0 Type III secretion system translocator protein, HrpF BRE1 PF08647.11 EFO64097.1 - 1.8 8.7 26.4 0.6 10.2 2.5 4.8 4 0 0 4 4 4 0 BRE1 E3 ubiquitin ligase LRR_1 PF00560.33 EFO64097.1 - 3 8.7 13.0 6.1 7.8 2.3 5.2 3 2 0 3 3 3 0 Leucine Rich Repeat EF-hand_6 PF13405.6 EFO64098.1 - 7.2e-12 44.2 0.0 0.0006 19.5 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 EFO64098.1 - 7.9e-12 43.8 0.0 0.00027 20.3 0.0 4.0 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 EFO64098.1 - 1.8e-09 37.9 0.1 4.4e-05 23.8 0.0 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EFO64098.1 - 1.5e-07 30.6 0.1 0.00067 19.0 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EFO64098.1 - 6.4e-07 29.1 0.3 0.0074 16.1 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain pair Metallophos PF00149.28 EFO64099.1 - 7.3e-19 69.1 0.2 1.4e-16 61.6 0.2 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_12 PF13424.6 EFO64099.1 - 0.0058 16.9 0.3 0.022 15.0 0.3 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFO64099.1 - 0.074 13.2 0.2 0.24 11.6 0.2 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFO64099.1 - 0.077 13.7 1.2 0.17 12.6 1.2 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat HGD-D PF06050.13 EFO64099.1 - 0.15 11.8 0.0 18 5.0 0.0 2.4 2 0 0 2 2 2 0 2-hydroxyglutaryl-CoA dehydratase, D-component Ank_2 PF12796.7 EFO64100.1 - 2.1e-79 262.2 29.9 4.1e-10 40.1 0.3 13.8 3 3 10 14 14 14 14 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64100.1 - 6e-49 163.5 31.7 0.002 18.4 0.0 18.2 11 5 8 20 20 20 12 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64100.1 - 7.8e-35 115.0 32.8 0.33 11.6 0.0 22.3 23 0 0 23 23 23 8 Ankyrin repeat Ank_4 PF13637.6 EFO64100.1 - 2.2e-34 117.4 20.4 0.0017 18.8 0.1 16.9 10 3 11 21 21 21 11 Ankyrin repeats (many copies) Ank PF00023.30 EFO64100.1 - 1.7e-33 113.6 38.0 0.022 15.2 0.0 20.6 20 3 1 21 21 21 10 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO64100.1 - 1e-11 44.5 11.0 2e-11 43.6 11.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO64100.1 - 5.1e-05 23.1 9.6 0.00011 22.0 9.6 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFO64100.1 - 0.092 13.1 12.2 0.2 12.0 12.2 1.6 1 0 0 1 1 1 0 Ring finger domain Gemini_AL1_M PF08283.11 EFO64100.1 - 0.11 12.6 0.0 0.43 10.7 0.0 1.9 1 0 0 1 1 1 0 Geminivirus rep protein central domain zf-RING_5 PF14634.6 EFO64100.1 - 0.41 10.6 11.1 1 9.4 11.1 1.7 1 0 0 1 1 1 0 zinc-RING finger domain Paramyxo_PNT PF14320.6 EFO64101.1 - 0.11 11.6 0.0 0.14 11.3 0.0 1.1 1 0 0 1 1 1 0 Phosphoprotein P region PNT disordered ProRS-C_1 PF09180.11 EFO64102.1 - 0.014 15.5 0.9 0.014 15.5 0.9 1.8 2 1 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal LapA_dom PF06305.11 EFO64102.1 - 0.019 14.7 0.6 0.029 14.2 0.6 1.2 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain WTF PF03303.13 EFO64102.1 - 0.064 13.0 0.1 0.098 12.4 0.1 1.3 1 0 0 1 1 1 0 WTF protein CcmD PF04995.14 EFO64102.1 - 0.52 10.4 6.2 0.27 11.3 4.3 1.5 1 1 1 2 2 2 0 Heme exporter protein D (CcmD) PolC_DP2 PF03833.13 EFO64102.1 - 0.66 7.8 3.4 0.71 7.7 3.4 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 AAA PF00004.29 EFO64104.1 - 5.1e-36 124.0 0.0 9.8e-36 123.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFO64104.1 - 6.4e-08 32.3 0.2 1.2e-07 31.4 0.2 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EFO64104.1 - 1.4e-07 31.4 0.0 2.7e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 EFO64104.1 - 3.9e-05 24.1 0.1 0.0035 17.7 0.0 2.5 2 1 0 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 EFO64104.1 - 0.00097 19.3 0.0 0.002 18.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EFO64104.1 - 0.0024 17.9 0.1 0.015 15.3 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EFO64104.1 - 0.0075 15.5 0.0 0.013 14.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TsaE PF02367.17 EFO64104.1 - 0.014 15.4 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 EFO64104.1 - 0.028 14.8 0.0 0.31 11.4 0.0 2.4 2 0 0 2 2 2 0 RNA helicase WEMBL PF05701.11 EFO64104.1 - 0.059 12.1 0.0 0.087 11.5 0.0 1.2 1 0 0 1 1 1 0 Weak chloroplast movement under blue light RuvB_N PF05496.12 EFO64104.1 - 0.069 12.9 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFO64104.1 - 0.088 13.1 0.2 5.9 7.2 0.0 2.7 1 1 1 2 2 2 0 AAA domain AAA_7 PF12775.7 EFO64104.1 - 0.098 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Rad17 PF03215.15 EFO64104.1 - 0.1 12.5 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Rad17 P-loop domain EF-hand_7 PF13499.6 EFO64105.1 - 1.3e-06 28.7 2.2 3.8e-05 24.0 2.2 2.3 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EFO64105.1 - 1.3e-05 24.5 0.5 3.6e-05 23.0 0.5 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EFO64105.1 - 0.00012 21.7 4.0 0.00037 20.2 0.2 3.1 3 1 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 EFO64105.1 - 0.0013 18.1 3.3 0.0015 18.0 0.1 2.7 4 0 0 4 4 4 1 EF hand CtsR_C PF17727.1 EFO64105.1 - 0.011 15.8 0.1 1.1 9.4 0.0 2.4 2 0 0 2 2 2 0 CtsR C-terminal dimerization domain ArsA_ATPase PF02374.15 EFO64106.1 - 2.4e-94 316.0 0.1 5.9e-94 314.7 0.1 1.5 1 1 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 EFO64106.1 - 3.6e-09 36.8 0.0 1e-08 35.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 EFO64106.1 - 7.9e-07 29.2 0.0 4.5e-06 26.7 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 EFO64106.1 - 0.0059 16.1 0.0 0.0096 15.4 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 EFO64106.1 - 0.017 14.6 0.0 0.081 12.4 0.0 2.0 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase SRP54 PF00448.22 EFO64106.1 - 0.074 12.7 0.0 0.3 10.7 0.0 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain FERM_N PF09379.10 EFO64106.1 - 0.14 12.2 0.0 0.38 10.7 0.0 1.8 1 1 0 1 1 1 0 FERM N-terminal domain ABC_tran PF00005.27 EFO64106.1 - 0.15 12.6 0.0 0.23 11.9 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 EFO64106.1 - 0.18 11.5 0.5 0.83 9.3 0.5 2.1 1 1 0 1 1 1 0 AAA domain PSI PF01437.25 EFO64107.1 - 3.1e-07 30.8 73.3 7.7e-05 23.2 13.4 5.5 4 1 1 5 5 5 3 Plexin repeat RIFIN PF02009.16 EFO64107.1 - 0.036 14.0 0.4 0.055 13.4 0.4 1.3 1 0 0 1 1 1 0 Rifin TMEM154 PF15102.6 EFO64107.1 - 0.051 13.5 0.4 0.086 12.7 0.4 1.3 1 0 0 1 1 1 0 TMEM154 protein family OAD_gamma PF04277.13 EFO64107.1 - 0.055 14.1 0.3 0.087 13.4 0.3 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Vpu PF00558.19 EFO64107.1 - 0.28 11.0 5.0 0.18 11.6 2.7 1.7 2 0 0 2 2 2 0 Vpu protein LRR_9 PF14580.6 EFO64108.1 - 1.8e-07 30.8 6.3 0.00045 19.8 0.3 3.0 2 1 1 3 3 3 2 Leucine-rich repeat LRR_8 PF13855.6 EFO64108.1 - 4.6e-07 29.5 19.0 0.0014 18.3 3.2 3.7 2 1 3 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 EFO64108.1 - 1.3e-06 28.6 19.0 0.057 13.9 0.6 4.0 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) FtsL PF04999.13 EFO64108.1 - 0.036 14.0 0.5 0.21 11.6 0.5 2.4 1 0 0 1 1 1 0 Cell division protein FtsL LRR_6 PF13516.6 EFO64108.1 - 0.2 11.8 11.4 29 5.1 0.1 5.7 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.33 EFO64108.1 - 1.1 10.1 11.4 24 6.0 0.0 5.3 3 2 0 3 3 3 0 Leucine Rich Repeat Filament PF00038.21 EFO64108.1 - 1.7 8.2 21.9 0.25 10.9 3.5 3.1 4 0 0 4 4 4 0 Intermediate filament protein Tropomyosin_1 PF12718.7 EFO64110.1 - 0.55 10.4 101.2 1.2 9.3 8.9 6.7 4 2 2 6 6 6 0 Tropomyosin like DUF599 PF04654.12 EFO64111.1 - 1.9 7.9 8.9 0.028 13.9 1.7 1.6 2 0 0 2 2 2 0 Protein of unknown function, DUF599 Sigma_reg_N PF13800.6 EFO64111.1 - 3.8 7.9 12.0 1.1 9.6 3.4 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Tubulin_3 PF14881.6 EFO64113.1 - 0.061 13.0 0.0 0.096 12.4 0.0 1.3 1 0 0 1 1 1 0 Tubulin domain Cas_APE2256 PF09651.10 EFO64113.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_APE2256) RIIa PF02197.17 EFO64114.1 - 2.1e-09 36.9 0.1 2.8e-09 36.5 0.1 1.2 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit EGF_2 PF07974.13 EFO64115.1 - 5.1e-31 106.7 173.7 7.3e-06 26.2 7.2 14.1 12 3 1 13 13 13 12 EGF-like domain Laminin_EGF PF00053.24 EFO64115.1 - 0.00058 19.9 10.1 0.00058 19.9 10.1 11.3 3 3 6 9 9 9 1 Laminin EGF domain EGF_Tenascin PF18720.1 EFO64115.1 - 0.0038 17.2 5.5 0.0038 17.2 5.5 16.7 13 5 4 17 17 17 4 Tenascin EGF domain EGF PF00008.27 EFO64115.1 - 0.0042 17.4 156.3 0.023 15.0 7.1 15.3 13 3 1 14 14 14 8 EGF-like domain EGF_CA PF07645.15 EFO64115.1 - 0.0067 16.6 8.2 0.0067 16.6 8.2 14.4 8 6 4 12 12 12 2 Calcium-binding EGF domain HSP70 PF00012.20 EFO64116.1 - 1.1e-161 539.1 0.9 5.8e-160 533.4 0.9 2.0 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFO64116.1 - 8.8e-11 41.2 0.9 7.4e-08 31.6 0.0 3.8 3 2 0 4 4 4 2 MreB/Mbl protein FGGY_C PF02782.16 EFO64116.1 - 0.038 13.7 0.0 0.075 12.8 0.0 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain SF3b1 PF08920.10 EFO64116.1 - 0.11 13.0 0.0 12 6.5 0.0 3.1 3 0 0 3 3 3 0 Splicing factor 3B subunit 1 FtsA PF14450.6 EFO64116.1 - 0.21 12.0 4.4 0.44 11.0 0.7 3.0 3 2 0 3 3 3 0 Cell division protein FtsA MFS_1 PF07690.16 EFO64117.1 - 2.7e-18 66.0 55.9 2.7e-18 66.0 55.9 3.1 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 EFO64117.1 - 1.1 7.7 49.2 0.21 10.1 27.9 3.0 1 1 1 3 3 3 0 MFS/sugar transport protein CARMIL_C PF16000.5 EFO64118.1 - 0.0059 16.3 0.3 0.0095 15.6 0.3 1.4 1 0 0 1 1 1 1 CARMIL C-terminus LEM PF03020.15 EFO64118.1 - 0.17 11.5 0.4 0.39 10.3 0.4 1.6 1 0 0 1 1 1 0 LEM domain JIP_LZII PF16471.5 EFO64119.1 - 1.1 9.5 15.5 0.78 10.0 0.6 3.5 3 0 0 3 3 3 0 JNK-interacting protein leucine zipper II bZIP_1 PF00170.21 EFO64119.1 - 6.2 7.0 23.0 0.15 12.1 1.4 4.9 4 1 1 5 5 5 0 bZIP transcription factor LPP PF04728.13 EFO64119.1 - 6.7 7.2 8.4 10 6.6 0.1 3.9 3 0 0 3 3 3 0 Lipoprotein leucine-zipper Kelch_4 PF13418.6 EFO64121.1 - 2e-14 53.3 0.9 1.4e-06 28.2 0.0 4.5 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EFO64121.1 - 3.4e-08 33.5 1.7 0.0022 18.2 0.0 3.6 2 1 1 3 3 3 2 Kelch motif Kelch_5 PF13854.6 EFO64121.1 - 5.7e-07 29.4 0.1 0.00025 21.0 0.1 2.8 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 EFO64121.1 - 2.2e-05 24.0 0.0 0.017 14.7 0.0 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 EFO64121.1 - 2.8e-05 24.3 1.5 0.0051 17.1 0.0 4.0 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.15 EFO64121.1 - 0.0001 22.1 0.2 0.61 10.2 0.1 3.1 3 0 0 3 3 3 2 Kelch motif KLRAQ PF10205.9 EFO64121.1 - 0.03 14.6 2.0 0.11 12.8 2.0 1.9 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein GIT_CC PF16559.5 EFO64121.1 - 0.033 14.1 0.7 0.074 12.9 0.7 1.6 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor JIP_LZII PF16471.5 EFO64121.1 - 0.056 13.6 2.5 0.13 12.5 2.5 1.6 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II DUF1664 PF07889.12 EFO64121.1 - 0.12 12.5 0.3 0.22 11.5 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) bZIP_1 PF00170.21 EFO64121.1 - 0.36 10.9 1.2 0.72 10.0 1.2 1.5 1 0 0 1 1 1 0 bZIP transcription factor YabA PF06156.13 EFO64121.1 - 6.3 7.5 7.3 0.76 10.5 1.8 2.3 2 0 0 2 2 2 0 Initiation control protein YabA Aa_trans PF01490.18 EFO64122.1 - 5.9e-26 91.1 35.8 1.1e-25 90.3 35.8 1.3 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EFO64122.1 - 0.069 12.2 37.7 0.023 13.7 33.9 2.1 2 1 0 2 2 2 0 Tryptophan/tyrosine permease family OAD_gamma PF04277.13 EFO64122.1 - 0.083 13.5 0.1 0.083 13.5 0.1 2.9 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain DUF4710 PF15828.5 EFO64122.1 - 0.13 12.4 0.7 0.26 11.4 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) HD_3 PF13023.6 EFO64126.1 - 2.1e-24 86.3 0.0 2.5e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 EFO64126.1 - 3.9e-06 26.8 0.1 6.2e-06 26.1 0.1 1.3 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 EFO64126.1 - 0.00093 19.4 0.2 0.0015 18.7 0.2 1.4 1 0 0 1 1 1 1 HD domain HDOD PF08668.12 EFO64126.1 - 0.045 13.2 0.1 0.097 12.1 0.0 1.5 1 1 0 1 1 1 0 HDOD domain PX PF00787.24 EFO64127.1 - 1.2e-09 38.1 0.0 5.6e-09 36.0 0.0 2.2 1 0 0 1 1 1 1 PX domain Ank_2 PF12796.7 EFO64128.1 - 1.6e-17 63.9 0.7 1.3e-12 48.1 0.5 3.4 1 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64128.1 - 8.8e-13 48.2 2.2 9.6e-06 25.8 0.4 5.2 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64128.1 - 2.8e-10 40.5 0.6 0.013 16.0 0.2 4.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO64128.1 - 1.4e-08 34.8 1.3 0.045 14.2 0.1 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EFO64128.1 - 2.2e-08 33.7 0.7 0.088 13.4 0.1 4.2 2 1 1 3 3 3 2 Ankyrin repeat Pkinase PF00069.25 EFO64128.1 - 0.0083 15.5 0.4 1.8 7.8 0.2 2.5 2 0 0 2 2 2 2 Protein kinase domain Aminotran_5 PF00266.19 EFO64129.1 - 1.7e-72 244.5 0.0 1.3e-68 231.7 0.0 2.1 1 1 1 2 2 2 2 Aminotransferase class-V Beta_elim_lyase PF01212.21 EFO64129.1 - 5.8e-06 25.8 0.0 7.8e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Pyridoxal_deC PF00282.19 EFO64129.1 - 0.014 14.1 0.0 0.028 13.1 0.0 1.4 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain DegT_DnrJ_EryC1 PF01041.17 EFO64129.1 - 0.067 12.5 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family VSP PF03302.13 EFO64131.1 - 5.5e-16 58.4 149.8 1.2e-06 27.7 17.8 6.2 1 1 5 6 6 6 5 Giardia variant-specific surface protein MLANA PF14991.6 EFO64131.1 - 0.0057 16.9 0.1 0.013 15.7 0.1 1.6 1 0 0 1 1 1 1 Protein melan-A DcuC PF03606.15 EFO64131.1 - 0.006 15.1 0.2 0.0086 14.6 0.2 1.1 1 0 0 1 1 1 1 C4-dicarboxylate anaerobic carrier ECSCR PF15820.5 EFO64131.1 - 0.014 15.2 1.6 0.036 13.9 1.6 1.7 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Phage_holin_3_6 PF07332.11 EFO64131.1 - 0.19 11.8 0.5 0.3 11.2 0.5 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Spt4 PF06093.13 EFO64132.1 - 9.8e-08 32.0 0.0 1.5e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger DUF1376 PF07120.11 EFO64132.1 - 0.05 13.9 0.0 0.59 10.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1376) HypA PF01155.19 EFO64132.1 - 0.057 13.4 0.1 0.072 13.1 0.1 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF1451 PF07295.11 EFO64132.1 - 0.065 13.3 1.3 0.094 12.7 1.3 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain RNA_POL_M_15KD PF02150.16 EFO64132.1 - 0.1 12.5 2.6 0.12 12.3 0.1 2.1 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit DUF2072 PF09845.9 EFO64132.1 - 0.16 12.3 1.2 0.28 11.4 0.9 1.6 1 1 1 2 2 2 0 Zn-ribbon containing protein Asp_protease PF09668.10 EFO64133.1 - 1.4e-25 89.5 0.1 3.5e-25 88.2 0.0 1.6 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 EFO64133.1 - 5e-13 49.4 0.0 1.1e-12 48.4 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EFO64133.1 - 2.1e-08 34.7 0.0 1.4e-07 32.0 0.0 2.1 2 0 0 2 2 2 1 Aspartyl protease RVP_2 PF08284.11 EFO64133.1 - 0.083 12.7 0.1 0.24 11.1 0.1 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease AhpC-TSA PF00578.21 EFO64134.1 - 5.6e-29 100.6 0.0 7.3e-29 100.2 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFO64134.1 - 3.9e-13 49.3 0.0 5.3e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EFO64134.1 - 1.7e-08 34.2 0.1 3.6e-08 33.1 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin DUF563 PF04577.14 EFO64134.1 - 0.15 12.2 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF563) Spc42p PF11544.8 EFO64135.1 - 0.38 10.8 2.9 9 6.4 0.6 2.5 2 0 0 2 2 2 0 Spindle pole body component Spc42p CENP-F_leu_zip PF10473.9 EFO64135.1 - 0.67 10.0 7.1 2.9 7.9 5.5 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PX PF00787.24 EFO64136.1 - 4.2e-12 46.1 0.0 1.2e-11 44.6 0.0 1.8 1 0 0 1 1 1 1 PX domain zf-C3HC4_3 PF13920.6 EFO64136.1 - 1.5e-07 31.1 13.7 1.3e-06 28.1 6.1 2.8 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFO64136.1 - 8.3e-06 25.7 8.5 8.3e-06 25.7 8.5 2.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFO64136.1 - 0.01 15.7 8.7 0.01 15.7 8.7 3.1 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO64136.1 - 0.18 11.7 19.2 0.072 13.0 6.6 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 zf-P11 PF03854.14 EFO64136.1 - 0.74 9.5 14.5 1.4 8.6 1.5 2.7 2 0 0 2 2 2 0 P-11 zinc finger zf-RING_2 PF13639.6 EFO64136.1 - 0.91 9.9 16.3 0.43 11.0 8.0 3.0 2 0 0 2 2 2 0 Ring finger domain PRIMA1 PF16101.5 EFO64136.1 - 0.98 9.5 9.0 2.6 8.1 9.0 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 zf-RING_4 PF14570.6 EFO64136.1 - 3.9 7.3 12.4 0.26 11.1 4.6 2.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 EFO64136.1 - 6.3 6.8 9.6 0.52 10.2 3.9 2.2 2 0 0 2 2 2 0 zf-RING of BARD1-type protein PX PF00787.24 EFO64137.1 - 4.2e-09 36.4 0.5 4.2e-09 36.4 0.5 2.4 2 1 0 2 2 2 1 PX domain GNAT_acetyltran PF12746.7 EFO64137.1 - 0.05 13.2 1.6 0.11 12.1 1.6 1.6 1 0 0 1 1 1 0 GNAT acetyltransferase PX PF00787.24 EFO64138.1 - 1.1e-13 51.1 2.9 1.4e-12 47.6 0.5 2.8 2 0 0 2 2 2 2 PX domain KIAA1430 PF13879.6 EFO64139.1 - 2.8e-07 31.2 1.1 8.2e-07 29.7 1.1 1.9 1 1 0 1 1 1 1 KIAA1430 homologue Smoa_sbd PF17885.1 EFO64139.1 - 0.0098 16.0 0.0 0.29 11.2 0.0 2.8 3 0 0 3 3 3 1 Styrene monooxygenase A putative substrate binding domain DUF3545 PF12065.8 EFO64139.1 - 9.1 6.4 7.5 3.9 7.6 1.9 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3545) Ank_2 PF12796.7 EFO64140.1 - 1.4e-10 41.6 0.1 8.1e-09 36.0 0.2 2.9 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64140.1 - 1.5e-07 31.5 0.8 0.0047 17.2 0.0 3.4 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64140.1 - 4.7e-07 30.2 0.5 0.0011 19.5 0.1 3.7 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64140.1 - 6.2e-06 26.2 0.1 0.015 15.8 0.0 3.5 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 EFO64140.1 - 7.4e-05 23.0 0.1 0.09 13.3 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat hDGE_amylase PF14701.6 EFO64140.1 - 1.1 8.3 6.3 0.18 10.9 0.6 2.1 1 1 1 2 2 2 0 Glycogen debranching enzyme, glucanotransferase domain LRR_4 PF12799.7 EFO64141.1 - 0.011 16.2 2.4 0.011 16.2 2.4 3.3 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO64141.1 - 0.074 12.8 7.8 0.058 13.2 2.1 2.6 1 1 0 2 2 2 0 Leucine rich repeat Pkinase PF00069.25 EFO64142.1 - 2.2e-67 227.2 0.0 2.7e-67 226.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64142.1 - 4.6e-45 153.9 0.0 6.3e-45 153.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO64142.1 - 6.9e-05 22.3 0.0 0.00023 20.6 0.0 1.6 1 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFO64142.1 - 0.11 11.2 0.0 0.21 10.3 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Terminase_3 PF04466.13 EFO64142.1 - 0.13 11.8 0.3 0.19 11.3 0.3 1.2 1 0 0 1 1 1 0 Phage terminase large subunit Elf4 PF07011.11 EFO64142.1 - 0.21 11.5 0.5 0.4 10.6 0.4 1.5 1 1 0 1 1 1 0 Early Flowering 4 domain UCH PF00443.29 EFO64143.1 - 6.8e-23 81.5 0.0 1.8e-22 80.1 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EFO64143.1 - 6.1e-15 55.3 12.4 6.1e-15 55.3 12.4 3.0 3 0 0 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 EFO64143.1 - 6.6e-09 35.4 8.9 6.6e-09 35.4 8.9 2.5 2 0 0 2 2 2 1 Variant UBP zinc finger UCH_1 PF13423.6 EFO64143.1 - 8.7e-07 28.8 2.5 1.1e-05 25.2 0.0 2.7 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 EFO64143.1 - 0.023 14.6 0.0 0.068 13.1 0.0 1.8 1 0 0 1 1 1 0 UBA/TS-N domain DUF3263 PF11662.8 EFO64143.1 - 0.023 14.5 0.0 0.064 13.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3263) UBA_4 PF14555.6 EFO64143.1 - 0.11 12.4 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 UBA-like domain Ank_2 PF12796.7 EFO64144.1 - 4.6e-29 100.8 4.2 6e-14 52.4 0.8 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64144.1 - 1.7e-13 50.7 2.7 5.7e-06 26.8 0.4 4.7 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO64144.1 - 3.2e-13 49.5 3.0 0.0033 17.8 0.4 5.8 4 1 1 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EFO64144.1 - 1.2e-12 47.7 6.5 0.035 14.4 0.5 5.5 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64144.1 - 8.4e-12 44.2 3.3 0.045 14.3 0.0 5.6 5 0 0 5 5 5 4 Ankyrin repeat Pkinase PF00069.25 EFO64144.1 - 4.2e-11 42.7 0.0 9.8e-10 38.2 0.0 2.6 2 1 0 2 2 2 1 Protein kinase domain Mpp10 PF04006.12 EFO64145.1 - 0.25 9.8 44.8 0.29 9.5 44.8 1.0 1 0 0 1 1 1 0 Mpp10 protein Nop14 PF04147.12 EFO64145.1 - 0.5 8.5 46.5 0.55 8.4 46.5 1.0 1 0 0 1 1 1 0 Nop14-like family RR_TM4-6 PF06459.12 EFO64145.1 - 1 9.2 29.2 1.4 8.7 29.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SDA1 PF05285.12 EFO64145.1 - 1.2 8.5 49.1 1.5 8.2 49.1 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 EFO64145.1 - 1.4 7.1 34.7 1.9 6.6 34.7 1.2 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 EFO64145.1 - 1.9 7.2 21.3 2.9 6.6 21.3 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4045 PF13254.6 EFO64145.1 - 3.9 7.0 23.7 4.3 6.9 23.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF2722 PF10846.8 EFO64145.1 - 4.6 6.1 20.4 5.6 5.8 20.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Presenilin PF01080.17 EFO64145.1 - 4.9 5.8 27.8 6.1 5.5 27.8 1.0 1 0 0 1 1 1 0 Presenilin Raftlin PF15250.6 EFO64145.1 - 5 5.8 20.4 5.7 5.6 20.4 1.0 1 0 0 1 1 1 0 Raftlin CCSAP PF15748.5 EFO64145.1 - 5.1 7.2 26.4 6.1 6.9 26.4 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF853 PF05872.12 EFO64145.1 - 6.1 5.3 9.5 6.9 5.1 9.5 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DUF5427 PF10310.9 EFO64145.1 - 6.5 5.6 26.4 9.1 5.1 26.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SLC12 PF03522.15 EFO64145.1 - 6.7 5.6 16.6 7.6 5.4 16.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Paramyxo_ncap PF00973.19 EFO64145.1 - 8.5 5.2 14.7 9.9 4.9 14.7 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein ALMT PF11744.8 EFO64145.1 - 9.5 4.9 14.4 11 4.8 14.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter ABC_tran PF00005.27 EFO64146.1 - 3.5e-45 153.9 0.0 9.7e-22 78.0 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 EFO64146.1 - 3.5e-19 69.1 57.9 9.8e-14 51.2 15.8 3.2 3 0 0 3 3 3 2 ABC-2 family transporter protein AAA_23 PF13476.6 EFO64146.1 - 6.4e-07 30.1 1.0 0.015 15.8 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 EFO64146.1 - 1.4e-05 24.7 0.3 0.19 11.5 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC2_membrane PF01061.24 EFO64146.1 - 1.9e-05 24.2 14.5 1.9e-05 24.2 14.5 4.9 5 1 0 6 6 6 2 ABC-2 type transporter RsgA_GTPase PF03193.16 EFO64146.1 - 0.00088 19.2 0.0 0.61 10.0 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase MukB PF04310.12 EFO64146.1 - 0.0096 15.7 0.1 1.8 8.3 0.0 2.6 2 0 0 2 2 2 1 MukB N-terminal Zeta_toxin PF06414.12 EFO64146.1 - 0.01 15.1 0.0 0.74 9.1 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin DUF87 PF01935.17 EFO64146.1 - 0.076 13.1 0.5 5.7 7.0 0.3 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain SRP54 PF00448.22 EFO64146.1 - 0.079 12.6 0.3 0.55 9.8 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Borrelia_lipo_1 PF05714.11 EFO64146.1 - 0.1 12.4 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein MMR_HSR1 PF01926.23 EFO64146.1 - 0.24 11.5 1.5 15 5.7 0.1 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase Ank_2 PF12796.7 EFO64147.1 - 1.7e-09 38.1 1.1 0.00042 20.9 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) UPF0242 PF06785.11 EFO64147.1 - 0.00011 22.4 11.8 0.0051 16.9 5.4 2.6 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0242) N-terminus FAM76 PF16046.5 EFO64147.1 - 0.046 13.1 8.3 0.025 14.0 4.7 1.9 2 0 0 2 2 2 0 FAM76 protein Spc42p PF11544.8 EFO64147.1 - 0.076 13.0 0.2 0.076 13.0 0.2 3.1 3 1 1 4 4 4 0 Spindle pole body component Spc42p BST2 PF16716.5 EFO64147.1 - 0.16 12.6 9.2 6.5 7.4 0.0 3.5 3 1 1 4 4 4 0 Bone marrow stromal antigen 2 DUF1824 PF08854.10 EFO64147.1 - 0.19 11.6 0.8 0.59 10.1 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1824) Med9 PF07544.13 EFO64147.1 - 0.23 11.6 12.2 0.07 13.2 3.7 3.1 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Fez1 PF06818.15 EFO64147.1 - 0.23 11.9 11.8 3.1 8.2 2.5 2.7 1 1 1 2 2 2 0 Fez1 Ank_3 PF13606.6 EFO64147.1 - 0.46 11.2 2.1 57 4.8 0.1 4.1 4 0 0 4 4 4 0 Ankyrin repeat CENP-F_leu_zip PF10473.9 EFO64147.1 - 0.53 10.3 18.6 2.1 8.3 0.3 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prominin PF05478.11 EFO64147.1 - 0.62 8.0 4.9 0.96 7.3 3.6 1.7 2 0 0 2 2 2 0 Prominin TMF_TATA_bd PF12325.8 EFO64147.1 - 1.1 9.5 14.8 28 5.0 0.0 2.9 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding CC2-LZ PF16516.5 EFO64147.1 - 1.1 9.6 12.6 3.7 8.0 0.1 3.2 2 1 1 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator THOC7 PF05615.13 EFO64147.1 - 1.2 9.4 13.9 0.51 10.6 8.3 2.4 2 0 0 2 2 2 0 Tho complex subunit 7 DUF4200 PF13863.6 EFO64147.1 - 1.2 9.5 17.3 1.2 9.5 0.2 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) TolA_bind_tri PF16331.5 EFO64147.1 - 1.5 9.0 7.0 7.2 6.8 2.6 2.8 2 1 1 3 3 3 0 TolA binding protein trimerisation Cep57_MT_bd PF06657.13 EFO64147.1 - 4.4 7.8 10.3 22 5.6 5.9 2.7 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Csm1_N PF18504.1 EFO64147.1 - 4.6 7.7 10.7 3 8.2 1.6 3.0 2 1 0 3 3 3 0 Csm1 N-terminal domain Cnn_1N PF07989.11 EFO64147.1 - 5.4 7.2 12.2 36 4.6 0.2 3.4 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 bZIP_1 PF00170.21 EFO64147.1 - 5.8 7.1 10.0 6.5 6.9 1.0 3.5 3 1 0 3 3 3 0 bZIP transcription factor Sec2p PF06428.11 EFO64147.1 - 9.9 6.2 16.2 4.9 7.2 11.1 2.7 2 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p Ank_2 PF12796.7 EFO64148.1 - 6e-51 171.0 22.5 1.3e-17 64.1 0.5 6.1 3 2 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64148.1 - 2.4e-32 110.6 3.3 7.7e-05 22.9 0.1 8.1 3 1 5 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64148.1 - 2.7e-28 94.9 1.1 0.0057 17.1 0.0 9.7 9 0 0 9 9 9 6 Ankyrin repeat Ank PF00023.30 EFO64148.1 - 5.2e-27 93.1 6.6 0.0018 18.6 0.0 9.1 7 2 2 9 9 9 7 Ankyrin repeat Ank_4 PF13637.6 EFO64148.1 - 2.4e-25 88.5 3.9 4.3e-06 27.2 0.0 7.5 7 1 0 8 8 8 4 Ankyrin repeats (many copies) DUF3447 PF11929.8 EFO64148.1 - 0.075 13.0 0.0 0.31 11.0 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3447) DUF4599 PF15371.6 EFO64148.1 - 2.4 8.7 6.8 8.6 7.0 0.3 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4599) GCP_N_terminal PF17681.1 EFO64149.1 - 1.8e-09 37.6 1.3 4.4e-09 36.4 0.1 2.2 3 0 0 3 3 3 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EFO64149.1 - 3.9e-08 33.1 0.5 5.8e-07 29.3 0.5 2.4 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal Thioredoxin_8 PF13905.6 EFO64150.1 - 0.00052 20.3 0.0 0.00084 19.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 EFO64150.1 - 0.0045 16.9 0.0 0.0062 16.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family DUF1405 PF07187.11 EFO64150.1 - 0.012 15.6 0.1 0.016 15.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1405) Thioredoxin_2 PF13098.6 EFO64150.1 - 0.017 15.6 0.0 0.026 14.9 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain Caa3_CtaG PF09678.10 EFO64152.1 - 0.13 11.7 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) Rhodanese PF00581.20 EFO64153.1 - 8.1e-07 29.5 0.0 1e-06 29.2 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain AAA_lid_9 PF17871.1 EFO64156.1 - 0.029 14.3 0.1 0.044 13.7 0.1 1.4 1 0 0 1 1 1 0 AAA lid domain MSP1a PF11670.8 EFO64157.1 - 0.053 12.8 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) Dynein_AAA_lid PF17852.1 EFO64157.1 - 0.12 12.5 0.8 0.93 9.6 0.0 2.7 2 1 0 3 3 3 0 Dynein heavy chain AAA lid domain FDF PF09532.10 EFO64157.1 - 6.9 7.6 7.4 2.3 9.2 3.8 2.1 2 1 0 2 2 2 0 FDF domain Ank_2 PF12796.7 EFO64159.1 - 8.4e-36 122.4 4.3 2.7e-10 40.7 0.1 5.3 3 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64159.1 - 2.2e-20 72.5 7.1 0.0026 18.0 0.0 7.4 3 3 4 7 7 7 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64159.1 - 7.4e-18 64.7 0.7 0.00042 20.8 0.0 5.9 5 1 1 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64159.1 - 8.5e-18 62.6 1.3 0.27 11.9 0.0 8.2 8 0 0 8 8 8 5 Ankyrin repeat Ank PF00023.30 EFO64159.1 - 6.5e-15 54.8 5.3 0.026 15.0 0.0 7.9 7 2 2 9 9 9 3 Ankyrin repeat Pkinase PF00069.25 EFO64159.1 - 6.1e-05 22.5 0.0 0.034 13.5 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64159.1 - 0.00013 21.4 0.0 0.071 12.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase VSP PF03302.13 EFO64161.1 - 3.9e-143 477.1 163.5 1.8e-132 442.0 96.4 3.5 1 1 2 3 3 3 2 Giardia variant-specific surface protein Toxin_10 PF05431.11 EFO64161.1 - 0.094 12.2 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 Insecticidal Crystal Toxin, P42 SNARE PF05739.19 EFO64162.1 - 6.9e-05 22.8 0.5 0.0002 21.3 0.1 2.0 2 0 0 2 2 2 1 SNARE domain Baculo_PEP_C PF04513.12 EFO64162.1 - 0.0019 18.3 11.3 0.022 14.8 3.3 3.1 2 1 1 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus Peripla_BP_2 PF01497.18 EFO64162.1 - 0.013 15.0 1.0 0.58 9.7 0.8 2.1 1 1 1 2 2 2 0 Periplasmic binding protein APG17 PF04108.12 EFO64162.1 - 0.018 14.2 5.1 0.031 13.4 0.5 2.2 1 1 0 2 2 2 0 Autophagy protein Apg17 NPV_P10 PF05531.12 EFO64162.1 - 0.044 14.2 10.9 0.4 11.2 0.5 3.3 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein RmuC PF02646.16 EFO64162.1 - 0.062 12.4 4.1 0.049 12.8 0.6 2.1 2 1 1 3 3 3 0 RmuC family bZIP_1 PF00170.21 EFO64162.1 - 0.11 12.6 6.7 0.73 10.0 0.2 3.6 4 0 0 4 4 4 0 bZIP transcription factor EzrA PF06160.12 EFO64162.1 - 0.17 10.0 4.7 0.21 9.8 0.9 2.0 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA DUF724 PF05266.14 EFO64162.1 - 0.25 11.1 1.5 7.2 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Apolipoprotein PF01442.18 EFO64162.1 - 0.26 11.2 3.8 0.61 9.9 0.3 2.2 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF1664 PF07889.12 EFO64162.1 - 0.26 11.3 6.5 3.5 7.7 1.7 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Snapin_Pallidin PF14712.6 EFO64162.1 - 0.3 11.5 6.6 1 9.8 0.1 2.7 3 1 0 3 3 2 0 Snapin/Pallidin Peptidase_M75 PF09375.10 EFO64162.1 - 0.34 10.3 2.6 0.3 10.5 0.4 1.9 2 0 0 2 2 2 0 Imelysin CREPT PF16566.5 EFO64162.1 - 0.44 10.7 3.5 2 8.6 0.6 2.2 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Spc7 PF08317.11 EFO64162.1 - 0.53 9.1 6.6 0.43 9.4 0.3 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Spc24 PF08286.11 EFO64162.1 - 0.9 9.8 7.9 6.1 7.1 1.0 3.1 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 CorA PF01544.18 EFO64162.1 - 1.6 8.0 6.5 0.74 9.1 0.8 2.2 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein DegS PF05384.11 EFO64162.1 - 1.9 8.0 7.3 1 8.9 0.1 2.9 2 1 1 3 3 3 0 Sensor protein DegS HR1 PF02185.16 EFO64162.1 - 3.4 7.8 7.7 9.8 6.4 0.3 3.6 3 1 0 3 3 3 0 Hr1 repeat Fib_alpha PF08702.10 EFO64162.1 - 6.5 6.9 7.2 22 5.2 2.1 3.2 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family TPR_MLP1_2 PF07926.12 EFO64162.1 - 7.9 6.5 7.5 11 6.0 0.3 2.9 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Kringle PF00051.18 EFO64163.1 - 0.11 12.8 0.1 0.32 11.4 0.1 1.7 1 0 0 1 1 1 0 Kringle domain Cyclin_N PF00134.23 EFO64164.1 - 0.066 13.0 0.0 0.098 12.4 0.0 1.4 1 1 0 1 1 1 0 Cyclin, N-terminal domain Thioredoxin PF00085.20 EFO64165.1 - 2.6e-05 24.2 0.0 0.0016 18.4 0.0 2.6 2 0 0 2 2 2 1 Thioredoxin Avl9 PF09794.9 EFO64165.1 - 0.00054 18.8 0.0 0.00084 18.1 0.0 1.2 1 0 0 1 1 1 1 Transport protein Avl9 Sugarporin_N PF11471.8 EFO64165.1 - 0.0082 16.1 0.2 0.019 14.9 0.2 1.7 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension PilJ PF13675.6 EFO64165.1 - 0.023 14.7 0.9 0.037 14.1 0.9 1.3 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term FlxA PF14282.6 EFO64165.1 - 0.051 13.6 1.5 0.051 13.6 1.5 2.3 1 1 0 1 1 1 0 FlxA-like protein Nup54 PF13874.6 EFO64165.1 - 0.26 11.4 5.1 0.45 10.6 5.1 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 CCDC32 PF14989.6 EFO64165.1 - 0.89 9.5 6.5 1.4 8.9 6.5 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing 32 Csm1_N PF18504.1 EFO64165.1 - 1.3 9.4 11.1 7.7 6.9 2.0 2.5 2 0 0 2 2 2 0 Csm1 N-terminal domain Prefoldin_2 PF01920.20 EFO64165.1 - 8 6.5 16.0 9.2 6.3 4.0 2.3 2 0 0 2 2 2 0 Prefoldin subunit EamA PF00892.20 EFO64166.1 - 3.5e-09 36.9 20.8 2.2e-06 27.9 4.0 4.1 3 1 0 3 3 3 2 EamA-like transporter family SLC35F PF06027.12 EFO64166.1 - 2.6e-05 23.9 12.4 2.6e-05 23.9 12.4 2.1 1 1 1 2 2 2 1 Solute carrier family 35 Peptidase_S49_N PF08496.10 EFO64167.1 - 0.34 11.0 1.6 0.5 10.4 1.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PhoLip_ATPase_C PF16212.5 EFO64168.1 - 7.3e-57 193.0 25.5 7.3e-57 193.0 25.5 2.0 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFO64168.1 - 3.2e-13 49.1 3.5 3.2e-13 49.1 3.5 2.3 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EFO64168.1 - 4.8e-11 43.4 0.0 0.0014 19.0 0.0 4.0 4 0 0 4 4 4 3 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EFO64168.1 - 3.1e-08 33.4 6.1 3.3e-08 33.3 0.0 3.0 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EFO64168.1 - 0.0051 16.6 0.2 0.02 14.6 0.1 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFO64168.1 - 0.0073 16.4 0.0 0.076 13.1 0.0 2.7 2 1 0 2 2 2 1 Cation transport ATPase (P-type) GIY-YIG PF01541.24 EFO64169.1 - 2.7e-12 46.8 0.0 5.9e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 GIY-YIG catalytic domain zf-C3HC4_3 PF13920.6 EFO64169.1 - 1.7e-05 24.6 7.4 3.5e-05 23.6 7.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFO64169.1 - 0.00014 22.1 9.3 0.00014 22.1 9.3 1.9 2 0 0 2 2 1 1 Ring finger domain Tmpp129 PF10272.9 EFO64169.1 - 0.019 14.3 1.2 0.026 13.9 1.2 1.3 1 0 0 1 1 1 0 Putative transmembrane protein precursor zf-C3HC4 PF00097.25 EFO64169.1 - 0.027 14.3 6.2 0.3 11.0 7.1 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EFO64169.1 - 0.043 13.6 6.5 0.15 11.8 6.7 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain DZR PF12773.7 EFO64169.1 - 0.08 13.0 6.1 6.1 7.0 1.9 2.4 1 1 1 2 2 2 0 Double zinc ribbon Rad50_zn_hook PF04423.14 EFO64169.1 - 0.097 12.5 0.9 0.45 10.4 0.1 2.3 2 0 0 2 2 2 0 Rad50 zinc hook motif T5orf172 PF10544.9 EFO64169.1 - 0.11 13.1 0.3 0.25 11.9 0.0 1.8 2 0 0 2 2 1 0 T5orf172 domain IBR PF01485.21 EFO64169.1 - 0.24 11.7 6.5 0.21 11.9 3.4 2.3 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain zf-TFIIIC PF12660.7 EFO64169.1 - 0.41 10.6 4.6 18 5.3 0.0 2.5 1 1 0 2 2 2 0 Putative zinc-finger of transcription factor IIIC complex zf-RING_5 PF14634.6 EFO64169.1 - 1 9.3 10.0 3.8 7.5 10.1 2.0 1 1 0 1 1 1 0 zinc-RING finger domain FYDLN_acid PF09538.10 EFO64169.1 - 1.3 9.7 4.1 1.4 9.7 1.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) YacG PF03884.14 EFO64169.1 - 1.9 8.3 7.5 0.43 10.4 0.1 2.6 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG Zn-C2H2_12 PF18112.1 EFO64169.1 - 2.4 8.7 4.4 12 6.5 0.2 2.7 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain Prok-RING_4 PF14447.6 EFO64169.1 - 3.3 7.6 8.7 20 5.2 0.3 2.7 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C2H2_4 PF13894.6 EFO64169.1 - 4 8.5 9.4 10 7.2 0.1 4.0 3 0 0 3 3 3 0 C2H2-type zinc finger zf-AN1 PF01428.16 EFO64169.1 - 5.1 7.3 8.6 11 6.3 3.7 2.4 1 1 1 2 2 2 0 AN1-like Zinc finger Prok-RING_1 PF14446.6 EFO64169.1 - 6.9 6.7 8.9 37 4.4 0.1 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-B_box PF00643.24 EFO64169.1 - 7.9 6.7 7.6 5.4 7.3 4.3 2.1 2 0 0 2 2 2 0 B-box zinc finger RmuC PF02646.16 EFO64170.1 - 0.0095 15.1 0.0 0.077 12.1 0.0 1.9 2 0 0 2 2 2 1 RmuC family Misat_Tub_SegII PF10644.9 EFO64170.1 - 0.014 15.7 0.0 0.03 14.6 0.0 1.6 1 1 0 1 1 1 0 Misato Segment II tubulin-like domain Tubulin PF00091.25 EFO64170.1 - 0.032 14.4 0.0 3.1 7.9 0.0 2.3 2 0 0 2 2 2 0 Tubulin/FtsZ family, GTPase domain DUF2569 PF10754.9 EFO64171.1 - 0.077 13.4 0.2 0.077 13.4 0.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2569) SPC12 PF06645.13 EFO64171.1 - 1.4 9.1 14.9 1.6 8.9 1.2 3.7 3 1 0 3 3 3 0 Microsomal signal peptidase 12 kDa subunit (SPC12) PIP5K PF01504.18 EFO64172.1 - 6.7e-60 202.6 0.0 1.4e-59 201.5 0.0 1.5 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF2284 PF10050.9 EFO64173.1 - 0.069 12.9 0.0 0.086 12.6 0.0 1.2 1 0 0 1 1 1 0 Predicted metal-binding protein (DUF2284) ACT_5 PF13710.6 EFO64173.1 - 0.072 12.9 0.2 0.46 10.4 0.1 2.1 1 1 0 2 2 2 0 ACT domain AATF-Che1 PF13339.6 EFO64173.1 - 0.077 13.7 0.3 0.1 13.3 0.3 1.1 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor DUF2294 PF10057.9 EFO64173.1 - 0.084 13.0 1.2 0.32 11.1 0.0 2.3 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2294) DHR10 PF18595.1 EFO64173.1 - 0.11 12.6 2.9 0.25 11.4 0.2 2.0 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain PHTB1_N PF14727.6 EFO64174.1 - 1.4e-91 307.9 0.0 1.8e-91 307.6 0.0 1.1 1 0 0 1 1 1 1 PTHB1 N-terminus Ribosomal_L21e PF01157.18 EFO64175.1 - 9.3e-41 137.8 4.2 1.3e-40 137.3 4.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L21e Gemini_coat PF00844.18 EFO64175.1 - 0.056 12.9 0.6 0.066 12.7 0.6 1.1 1 0 0 1 1 1 0 Geminivirus coat protein/nuclear export factor BR1 family RPW8 PF05659.11 EFO64177.1 - 2.9 7.6 7.5 1.1 9.0 0.7 3.0 2 2 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 APG6_N PF17675.1 EFO64177.1 - 6.8 7.2 12.7 3.2 8.3 4.5 2.9 2 0 0 2 2 2 0 Apg6 coiled-coil region LRR_9 PF14580.6 EFO64178.1 - 3.3e-14 52.8 5.4 1.2e-07 31.4 0.1 2.6 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 EFO64178.1 - 1.1e-12 47.9 20.5 1.2e-05 25.6 1.8 4.5 3 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO64178.1 - 3.8e-11 42.6 11.6 2.3e-05 24.1 1.4 3.7 2 1 1 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 EFO64178.1 - 3.4e-05 23.5 10.0 0.63 10.2 0.0 5.3 5 0 0 5 5 5 3 Leucine Rich repeat LRR_1 PF00560.33 EFO64178.1 - 0.046 14.3 8.3 3.5 8.5 0.2 4.8 5 0 0 5 5 5 0 Leucine Rich Repeat Urm1 PF09138.11 EFO64179.1 - 1.9e-24 85.8 0.1 2.1e-24 85.7 0.1 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 EFO64179.1 - 4.9e-06 27.1 0.0 5.8e-06 26.9 0.0 1.3 1 1 0 1 1 1 1 ThiS family TrkA_C PF02080.21 EFO64179.1 - 0.013 15.3 0.1 0.024 14.5 0.1 1.4 1 0 0 1 1 1 0 TrkA-C domain Glug PF07581.12 EFO64181.1 - 0.0055 17.0 0.8 0.0055 17.0 0.8 12.3 11 1 1 12 12 12 3 The GLUG motif LD_cluster3 PF18180.1 EFO64181.1 - 0.16 11.6 0.0 0.31 10.6 0.0 1.4 1 0 0 1 1 1 0 SLOG cluster3 family Pkinase PF00069.25 EFO64183.1 - 2.2e-62 210.8 0.0 4.1e-62 209.9 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64183.1 - 1.7e-43 148.8 0.0 2.7e-43 148.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFO64183.1 - 2.6e-05 23.2 0.0 0.00017 20.5 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EFO64183.1 - 0.027 13.8 0.2 0.1 11.9 0.0 2.0 3 0 0 3 3 3 0 Kinase-like PSD4 PF07631.11 EFO64184.1 - 0.38 11.3 6.5 1.5 9.4 6.5 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1592) BING4CT PF08149.11 EFO64185.1 - 1.4e-18 66.4 0.0 4.8e-18 64.7 0.0 1.9 1 0 0 1 1 1 1 BING4CT (NUC141) domain Thioredoxin PF00085.20 EFO64187.1 - 3.9e-05 23.6 0.0 7.9e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Ank_2 PF12796.7 EFO64189.1 - 5.8e-25 87.7 10.3 2.4e-09 37.6 0.4 5.4 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO64189.1 - 1.5e-11 43.5 11.3 0.9 10.3 0.1 8.1 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 EFO64189.1 - 2.6e-11 43.6 7.8 0.001 19.3 0.1 6.2 6 1 1 7 7 7 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64189.1 - 3.1e-08 34.0 6.2 0.24 12.0 0.7 6.2 5 0 0 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO64189.1 - 3.2e-08 33.6 16.3 1.6 9.3 0.4 7.8 6 2 1 7 7 7 4 Ankyrin repeat Pkinase PF00069.25 EFO64190.1 - 3.6e-33 115.0 0.0 4.2e-33 114.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64190.1 - 1.1e-19 70.8 0.0 1.3e-19 70.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO64190.1 - 4.1e-05 23.0 0.0 6.9e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Kinase-like CENP-F_leu_zip PF10473.9 EFO64193.1 - 0.00066 19.7 2.0 0.00066 19.7 2.0 4.6 4 2 0 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Baculo_PEP_C PF04513.12 EFO64193.1 - 0.046 13.8 0.2 0.046 13.8 0.2 6.2 5 1 1 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1843 PF08898.10 EFO64193.1 - 0.17 12.4 0.7 1.4 9.5 0.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) NPV_P10 PF05531.12 EFO64193.1 - 1.3 9.5 15.6 0.24 11.9 0.2 5.0 3 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein T7SS_ESX_EspC PF10824.8 EFO64193.1 - 9.3 6.8 14.6 0.63 10.5 0.6 4.2 5 0 0 5 5 5 0 Excreted virulence factor EspC, type VII ESX diderm Pkinase PF00069.25 EFO64196.1 - 7.5e-17 61.6 0.0 2e-16 60.2 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64196.1 - 1.4e-10 40.9 0.0 3.9e-10 39.5 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO64196.1 - 2.9e-05 23.5 0.0 6e-05 22.5 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Pkinase PF00069.25 EFO64197.1 - 3.3e-37 128.3 0.0 6.6e-37 127.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64197.1 - 3.1e-23 82.4 0.0 2.2e-22 79.6 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO64197.1 - 0.018 14.4 0.0 0.028 13.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Pox_ser-thr_kin PF05445.11 EFO64197.1 - 0.091 11.7 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Mob1_phocein PF03637.17 EFO64198.1 - 1.7e-58 197.4 0.2 2.1e-58 197.1 0.2 1.0 1 0 0 1 1 1 1 Mob1/phocein family Fur_reg_FbpA PF13076.6 EFO64198.1 - 0.12 12.1 0.1 0.31 10.8 0.1 1.7 1 0 0 1 1 1 0 Fur-regulated basic protein A F_bP_aldolase PF01116.20 EFO64199.1 - 2.3e-98 329.1 0.1 2.7e-98 328.9 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II YcgR PF07317.12 EFO64199.1 - 0.011 15.6 0.1 0.99 9.3 0.0 2.2 2 0 0 2 2 2 0 Flagellar regulator YcgR AIP3 PF03915.13 EFO64200.1 - 0.014 14.5 0.2 0.014 14.5 0.2 2.5 3 0 0 3 3 3 0 Actin interacting protein 3 TMF_TATA_bd PF12325.8 EFO64200.1 - 0.018 15.3 2.3 0.31 11.3 0.4 2.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Golgin_A5 PF09787.9 EFO64200.1 - 1.5 8.2 5.2 0.31 10.5 0.1 2.3 3 0 0 3 3 3 0 Golgin subfamily A member 5 Actin PF00022.19 EFO64201.1 - 9.7e-09 34.3 0.0 3.1e-08 32.6 0.0 1.8 2 0 0 2 2 2 1 Actin DUF498 PF04430.14 EFO64201.1 - 0.0079 16.2 0.0 0.02 14.9 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Trypan_PARP PF05887.11 EFO64201.1 - 2.3 8.2 4.1 4.2 7.4 4.1 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Pkinase PF00069.25 EFO64203.1 - 2.7e-153 508.8 0.0 1.1e-38 133.2 0.0 7.6 7 0 0 7 7 7 7 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64203.1 - 6.5e-79 264.9 3.2 1.9e-27 96.2 0.2 7.5 8 1 0 8 8 8 6 Protein tyrosine kinase Kinase-like PF14531.6 EFO64203.1 - 1.8e-12 47.2 0.0 0.004 16.5 0.0 6.3 6 0 0 6 6 6 4 Kinase-like Ank_2 PF12796.7 EFO64204.1 - 9.5e-31 106.2 8.7 2.5e-08 34.4 0.1 5.8 3 2 3 6 6 6 5 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64204.1 - 1.5e-17 63.2 1.3 0.0075 16.7 0.0 9.1 9 0 0 9 9 9 2 Ankyrin repeat Ank_5 PF13857.6 EFO64204.1 - 5.2e-15 55.3 5.5 2.7e-07 30.7 0.1 6.2 3 2 1 5 5 5 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64204.1 - 3.1e-13 49.9 0.5 1.6e-09 38.1 0.1 5.0 3 3 3 6 6 6 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64204.1 - 2e-12 46.1 2.5 0.084 13.5 0.0 7.2 6 0 0 6 6 6 2 Ankyrin repeat KLRAQ PF10205.9 EFO64204.1 - 7.5 6.9 8.2 25 5.2 0.4 3.8 3 0 0 3 3 3 0 Predicted coiled-coil domain-containing protein Transposase_24 PF03004.14 EFO64206.1 - 0.063 13.4 0.6 0.13 12.4 0.1 1.9 2 0 0 2 2 2 0 Plant transposase (Ptta/En/Spm family) Cyclin_N PF00134.23 EFO64207.1 - 0.0028 17.4 0.0 0.0079 15.9 0.0 1.8 1 0 0 1 1 1 1 Cyclin, N-terminal domain Pkinase PF00069.25 EFO64209.1 - 2.4e-60 204.2 0.0 3.6e-60 203.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64209.1 - 2.1e-36 125.6 0.0 3.1e-36 125.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO64209.1 - 5.2e-24 84.6 1.0 6.7e-10 39.4 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO64209.1 - 9.8e-16 56.3 0.8 0.0012 19.1 0.0 6.0 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EFO64209.1 - 1.6e-11 44.2 1.9 0.00015 22.0 0.0 5.1 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO64209.1 - 3e-11 43.2 0.6 0.038 14.4 0.0 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EFO64209.1 - 2.1e-10 40.9 0.3 0.0023 18.5 0.0 4.3 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Kinase-like PF14531.6 EFO64209.1 - 0.0007 19.0 0.1 0.0027 17.1 0.0 2.1 3 0 0 3 3 3 1 Kinase-like Haspin_kinase PF12330.8 EFO64209.1 - 0.0027 16.7 0.1 0.016 14.2 0.1 2.1 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFO64209.1 - 0.009 15.9 0.1 0.031 14.2 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family DUF1611 PF07755.11 EFO64209.1 - 0.11 11.7 0.1 0.39 9.9 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1611_C) P-loop domain Nrap_D5 PF17406.2 EFO64210.1 - 2.3e-07 30.7 0.6 0.026 14.3 0.0 3.5 3 0 0 3 3 3 3 Nrap protein PAP/OAS1-like domain 5 Nrap_D4 PF17405.2 EFO64210.1 - 0.08 12.3 0.0 0.34 10.2 0.0 1.9 2 0 0 2 2 2 0 Nrap protein nucleotidyltransferase domain 4 Cdc6_C PF09079.11 EFO64210.1 - 0.12 12.4 0.0 0.37 10.8 0.0 1.8 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain Fes1 PF08609.10 EFO64211.1 - 1.4e-05 25.8 0.3 4.1e-05 24.4 0.1 1.9 2 0 0 2 2 2 1 Nucleotide exchange factor Fes1 V-ATPase_H_C PF11698.8 EFO64211.1 - 0.0018 18.4 0.0 0.0033 17.5 0.0 1.4 1 0 0 1 1 1 1 V-ATPase subunit H Gcn1_N PF12074.8 EFO64211.1 - 0.035 13.4 0.0 0.048 13.0 0.0 1.1 1 0 0 1 1 1 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal DRIM PF07539.12 EFO64211.1 - 0.049 11.9 0.4 0.059 11.7 0.4 1.1 1 0 0 1 1 1 0 Down-regulated in metastasis Phage_tail_NK PF16532.5 EFO64211.1 - 0.056 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Sf6-type phage tail needle knob or tip of some Caudovirales HEAT PF02985.22 EFO64211.1 - 0.059 13.7 0.1 0.24 11.8 0.0 2.1 2 0 0 2 2 2 0 HEAT repeat HEAT_2 PF13646.6 EFO64211.1 - 0.087 13.2 0.5 1.1 9.6 0.0 2.5 2 1 0 3 3 3 0 HEAT repeats DnaB PF00772.21 EFO64211.1 - 0.17 12.0 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase N terminal domain tRNA-synt_2b PF00587.25 EFO64212.1 - 8.6e-29 100.8 0.1 3.8e-27 95.4 0.1 2.4 1 1 1 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EFO64212.1 - 5.6e-21 74.8 3.3 1e-20 73.9 3.3 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain PIN_9 PF18477.1 EFO64212.1 - 0.00055 20.2 0.5 0.0028 18.0 1.1 1.9 2 0 0 2 2 2 1 PIN like domain CAP59_mtransfer PF11735.8 EFO64212.1 - 0.0053 16.5 0.3 0.044 13.5 0.4 2.0 2 0 0 2 2 2 1 Cryptococcal mannosyltransferase 1 GAS PF13851.6 EFO64212.1 - 0.009 15.4 2.5 0.017 14.5 2.5 1.4 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding End3 PF12761.7 EFO64212.1 - 0.019 15.1 2.0 0.019 15.1 2.0 1.6 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 DUF1966 PF09260.11 EFO64212.1 - 0.086 13.1 0.0 0.21 11.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1966) Packaging_FI PF14000.6 EFO64212.1 - 0.18 12.2 1.0 0.38 11.2 1.0 1.4 1 0 0 1 1 1 0 DNA packaging protein FI DUF948 PF06103.11 EFO64212.1 - 1.4 9.2 4.1 0.61 10.4 0.5 2.2 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) SDH_alpha PF03313.15 EFO64213.1 - 2.8e-53 181.2 0.4 2.2e-52 178.3 0.4 1.9 1 1 0 1 1 1 1 Serine dehydratase alpha chain SDH_beta PF03315.15 EFO64213.1 - 4.4e-26 92.1 0.3 5.8e-15 56.0 0.2 2.6 1 1 1 2 2 2 2 Serine dehydratase beta chain BRE1 PF08647.11 EFO64214.1 - 0.00023 21.2 9.5 0.00023 21.2 9.5 9.7 3 3 5 9 9 9 3 BRE1 E3 ubiquitin ligase DUF641 PF04859.12 EFO64214.1 - 0.0065 16.8 7.0 0.0065 16.8 7.0 7.8 3 2 4 7 7 7 2 Plant protein of unknown function (DUF641) Laminin_II PF06009.12 EFO64214.1 - 0.014 15.4 4.5 0.014 15.4 4.5 8.7 2 1 5 9 9 9 0 Laminin Domain II CENP-F_leu_zip PF10473.9 EFO64214.1 - 0.014 15.4 2.0 0.014 15.4 2.0 8.6 4 3 4 8 8 8 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.11 EFO64214.1 - 0.55 10.7 52.6 0.24 11.8 0.9 10.7 8 3 4 12 12 12 0 Flagella accessory protein C (FlaC) APG6_N PF17675.1 EFO64214.1 - 5.2 7.6 119.7 0.22 12.0 18.7 8.5 2 1 6 8 8 8 0 Apg6 coiled-coil region VSP PF03302.13 EFO64215.1 - 1e-75 255.1 176.7 1.3e-69 235.0 87.7 4.7 1 1 4 5 5 5 4 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO64215.1 - 0.00013 22.1 16.7 0.00013 22.1 16.7 12.2 2 2 9 12 12 12 3 Furin-like repeat, cysteine-rich Peptidase_C27 PF05407.12 EFO64215.1 - 0.022 14.9 0.6 0.022 14.9 0.6 1.9 2 0 0 2 2 2 0 Rubella virus endopeptidase T4SS_CagC PF16943.5 EFO64215.1 - 0.11 12.7 0.5 0.27 11.4 0.5 1.6 1 0 0 1 1 1 0 Cag pathogenicity island, type IV secretory system zf-RING_5 PF14634.6 EFO64216.1 - 0.096 12.7 12.0 0.44 10.5 12.0 2.3 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 EFO64216.1 - 0.15 12.0 8.2 0.45 10.4 8.2 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EFO64216.1 - 0.81 9.6 13.7 0.9 9.5 10.7 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EFO64216.1 - 1.4 8.8 15.3 1.3 8.9 10.7 2.7 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4_2 PF13923.6 EFO64216.1 - 8.6 6.3 14.8 5.1 7.0 9.8 2.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) IF-2B PF01008.17 EFO64217.1 - 7.7e-28 97.5 0.1 1.3e-27 96.8 0.1 1.3 1 0 0 1 1 1 1 Initiation factor 2 subunit family IQ PF00612.27 EFO64218.1 - 0.0014 18.3 17.4 0.062 13.1 1.6 4.0 3 0 0 3 3 3 2 IQ calmodulin-binding motif DUF5591 PF17884.1 EFO64218.1 - 0.087 12.7 0.0 1.3 8.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5591) EMG1 PF03587.14 EFO64219.1 - 2.2e-70 236.3 0.0 2.5e-70 236.1 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase V-SNARE_C PF12352.8 EFO64220.1 - 5.7e-05 23.3 3.2 8.6e-05 22.7 0.3 2.4 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus DUF5089 PF17002.5 EFO64220.1 - 0.003 17.5 0.9 0.003 17.5 0.9 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF5089) PTN13_u3 PF16599.5 EFO64220.1 - 0.0031 17.6 3.5 0.0048 17.0 3.5 1.3 1 0 0 1 1 1 1 Unstructured linker region on PTN13 protein between PDZ Herpes_UL6 PF01763.16 EFO64220.1 - 0.014 14.0 5.2 0.016 13.7 5.2 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like Uds1 PF15456.6 EFO64220.1 - 0.065 13.4 11.5 0.053 13.7 9.7 1.8 1 1 1 2 2 2 0 Up-regulated During Septation DHR10 PF18595.1 EFO64220.1 - 0.2 11.7 17.4 0.21 11.6 9.2 2.7 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain FlxA PF14282.6 EFO64220.1 - 0.25 11.4 10.8 0.55 10.3 10.8 1.6 1 0 0 1 1 1 0 FlxA-like protein AAA_13 PF13166.6 EFO64220.1 - 0.49 9.0 11.5 0.56 8.8 11.5 1.0 1 0 0 1 1 1 0 AAA domain CENP-O PF09496.10 EFO64220.1 - 0.59 10.1 4.7 0.76 9.7 4.7 1.1 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component Uso1_p115_C PF04871.13 EFO64220.1 - 5.6 7.3 12.7 9 6.7 12.4 1.7 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region XhlA PF10779.9 EFO64220.1 - 6.6 7.0 8.2 46 4.3 0.1 3.4 3 1 0 3 3 3 0 Haemolysin XhlA Arm PF00514.23 EFO64221.1 - 0.00015 21.7 11.9 0.13 12.4 0.1 5.9 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EFO64221.1 - 0.075 13.4 1.0 41 4.7 0.0 4.3 4 1 0 4 4 4 0 HEAT repeats HEAT PF02985.22 EFO64221.1 - 0.11 12.8 6.1 2.7 8.5 0.2 5.4 5 0 0 5 5 5 0 HEAT repeat RTP1_C1 PF10363.9 EFO64221.1 - 0.17 12.1 0.5 0.58 10.4 0.1 2.1 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 RICTOR_V PF14668.6 EFO64221.1 - 0.18 12.1 1.8 1.2 9.4 0.1 3.1 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 LacAB_rpiB PF02502.18 EFO64223.1 - 2.3e-51 173.5 0.1 2.5e-51 173.3 0.1 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase TPR_2 PF07719.17 EFO64226.1 - 0.12 12.6 0.1 14 6.1 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat PqiA PF04403.13 EFO64226.1 - 0.25 11.2 0.0 0.34 10.7 0.0 1.1 1 0 0 1 1 1 0 Paraquat-inducible protein A Antimicrobial14 PF08109.11 EFO64227.1 - 0.12 12.5 0.2 0.23 11.5 0.2 1.4 1 0 0 1 1 1 0 Lactocin 705 family Baculo_PEP_C PF04513.12 EFO64227.1 - 0.49 10.4 4.8 0.27 11.3 1.4 2.3 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_2 PF07719.17 EFO64228.1 - 2.3e-39 130.3 44.5 7e-05 22.7 0.0 17.3 18 0 0 18 18 17 7 Tetratricopeptide repeat TPR_1 PF00515.28 EFO64228.1 - 4.9e-39 130.6 37.8 8.6e-06 25.4 0.0 16.0 17 0 0 17 17 16 9 Tetratricopeptide repeat TPR_11 PF13414.6 EFO64228.1 - 4.8e-19 67.8 5.8 0.00029 20.5 0.0 8.6 7 2 2 9 9 9 3 TPR repeat TPR_8 PF13181.6 EFO64228.1 - 9e-19 66.1 32.6 0.1 12.9 0.7 14.3 16 0 0 16 16 16 7 Tetratricopeptide repeat TPR_17 PF13431.6 EFO64228.1 - 6.3e-16 57.5 8.0 0.073 13.5 0.0 11.1 12 0 0 12 12 12 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFO64228.1 - 9.7e-11 42.1 25.2 0.014 16.0 0.0 10.1 8 3 2 11 11 11 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFO64228.1 - 6.1e-08 32.8 36.2 0.017 15.4 0.8 11.5 10 4 2 12 12 12 3 Tetratricopeptide repeat TPR_9 PF13371.6 EFO64228.1 - 1.4e-07 31.6 16.2 0.0078 16.3 0.1 8.6 6 3 3 9 9 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFO64228.1 - 1.8e-06 28.3 16.1 14 6.2 0.0 8.8 7 3 3 10 10 9 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFO64228.1 - 2.7e-05 24.5 22.1 1.3 9.9 0.2 9.5 12 0 0 12 12 10 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFO64228.1 - 3.9e-05 23.8 18.4 0.0051 17.0 2.2 6.6 5 2 3 8 8 8 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EFO64228.1 - 0.00024 20.9 6.6 1.8 8.8 0.1 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat Paf67 PF10255.9 EFO64228.1 - 0.012 14.6 0.2 2.5 7.0 0.0 2.7 2 0 0 2 2 2 0 RNA polymerase I-associated factor PAF67 UVR PF02151.19 EFO64228.1 - 0.05 13.4 1.4 6.5 6.6 0.0 3.2 2 0 0 2 2 2 0 UvrB/uvrC motif BTAD PF03704.17 EFO64228.1 - 0.26 11.7 2.2 5.4 7.4 0.0 3.8 5 0 0 5 5 3 0 Bacterial transcriptional activator domain TPR_14 PF13428.6 EFO64228.1 - 0.5 11.3 27.5 37 5.5 0.0 9.6 10 1 1 11 11 11 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFO64228.1 - 1.1 9.4 10.3 0.39 10.8 0.1 5.0 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat Pkinase PF00069.25 EFO64229.1 - 3.9e-53 180.5 0.0 1.1e-50 172.5 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Ank_2 PF12796.7 EFO64229.1 - 1.9e-51 172.6 12.0 1e-14 54.9 0.1 6.1 1 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64229.1 - 1e-28 99.3 6.5 4.1e-06 27.2 0.1 7.9 5 1 3 8 8 8 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO64229.1 - 3.4e-28 97.3 9.3 0.00012 22.3 0.1 9.5 3 2 7 10 10 10 7 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO64229.1 - 2e-27 96.1 0.0 2.2e-26 92.7 0.0 2.6 2 1 0 2 2 2 1 Protein tyrosine kinase Ank PF00023.30 EFO64229.1 - 1.4e-23 82.2 7.3 0.0046 17.4 0.0 10.4 8 2 2 10 10 10 7 Ankyrin repeat Ank_3 PF13606.6 EFO64229.1 - 6.9e-22 75.2 1.3 0.31 11.7 0.0 10.3 10 0 0 10 10 10 5 Ankyrin repeat Kinase-like PF14531.6 EFO64229.1 - 4.6e-06 26.1 0.0 9.8e-06 25.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFO64229.1 - 0.09 11.7 0.0 3.7 6.4 0.0 2.4 2 0 0 2 2 2 0 Haspin like kinase domain Myb_DNA-binding PF00249.31 EFO64230.1 - 0.00015 21.9 0.0 0.00032 20.8 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFO64230.1 - 0.0002 21.2 0.0 0.0005 19.9 0.0 1.6 1 0 0 1 1 1 1 Myb DNA-binding like SANT_DAMP1_like PF16282.5 EFO64230.1 - 0.012 15.8 0.1 0.036 14.3 0.0 1.9 2 0 0 2 2 2 0 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_6 PF13921.6 EFO64230.1 - 0.063 13.5 0.0 0.18 12.0 0.0 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain eRF1_2 PF03464.15 EFO64231.1 - 5.3e-38 130.3 0.0 9.3e-38 129.6 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EFO64231.1 - 3e-36 124.3 0.0 2.3e-34 118.3 0.0 2.4 2 0 0 2 2 2 1 eRF1 domain 3 eRF1_1 PF03463.15 EFO64231.1 - 1.2e-11 44.7 0.0 2.1e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 EFO64231.1 - 4.2e-09 36.8 0.0 6.3e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 EFO64231.1 - 2.4e-05 24.6 0.0 4.3e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 7TM_GPCR_Sra PF02117.16 EFO64231.1 - 0.052 12.4 0.1 0.077 11.8 0.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sra Rad51 PF08423.11 EFO64232.1 - 2.7e-114 380.7 0.0 3.6e-114 380.3 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EFO64232.1 - 3.4e-12 46.4 0.1 5.3e-12 45.8 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 EFO64232.1 - 5.9e-05 22.5 0.0 0.00016 21.1 0.0 1.9 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 EFO64232.1 - 8e-05 22.3 0.2 0.0007 19.2 0.0 2.2 1 1 1 2 2 2 1 AAA domain HHH_5 PF14520.6 EFO64232.1 - 0.00057 20.4 0.3 0.0057 17.2 0.7 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix domain AAA_24 PF13479.6 EFO64232.1 - 0.0084 15.8 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_pol_A_CTD PF03118.15 EFO64232.1 - 0.014 15.2 0.1 0.03 14.1 0.1 1.5 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain DnaB_C PF03796.15 EFO64232.1 - 0.066 12.5 0.0 0.23 10.7 0.0 1.9 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain CBS PF00571.28 EFO64233.1 - 1.2e-28 99.3 1.7 7.3e-07 29.5 0.0 4.4 4 0 0 4 4 4 4 CBS domain Filament PF00038.21 EFO64234.1 - 0.0018 17.9 33.7 0.0018 17.9 33.7 12.0 4 2 5 11 11 11 5 Intermediate filament protein Ank_2 PF12796.7 EFO64236.1 - 1.8e-50 169.4 17.6 5e-14 52.6 0.4 5.3 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO64236.1 - 1.7e-32 112.8 0.0 1.6e-31 109.6 0.0 2.5 3 1 0 3 3 3 1 Protein kinase domain Ank_3 PF13606.6 EFO64236.1 - 5e-26 87.9 0.8 0.0015 18.9 0.0 8.8 9 1 0 9 9 8 5 Ankyrin repeat Ank_5 PF13857.6 EFO64236.1 - 3.9e-25 87.6 1.6 0.00045 20.5 0.0 8.5 4 2 5 9 9 9 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64236.1 - 1.6e-24 85.9 2.3 4.2e-05 24.0 0.0 7.6 4 2 5 9 9 8 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO64236.1 - 1.6e-22 78.9 3.6 0.0007 19.9 0.0 8.5 9 0 0 9 9 9 5 Ankyrin repeat Pkinase_Tyr PF07714.17 EFO64236.1 - 3.6e-21 75.6 0.0 1e-20 74.1 0.0 1.8 1 0 0 1 1 1 1 Protein tyrosine kinase Phage_T7_Capsid PF05396.11 EFO64236.1 - 0.00083 19.7 5.6 0.17 12.2 0.0 3.9 4 0 0 4 4 4 1 Phage T7 capsid assembly protein SlyX PF04102.12 EFO64236.1 - 0.012 16.3 0.1 0.03 14.9 0.1 1.6 1 0 0 1 1 1 0 SlyX Phage_Mu_Gam PF07352.12 EFO64236.1 - 0.015 15.2 0.2 0.049 13.6 0.2 1.9 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein Mod_r PF07200.13 EFO64236.1 - 0.019 15.1 0.3 0.052 13.6 0.3 1.8 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein SKA1 PF07160.12 EFO64236.1 - 0.051 13.4 0.3 0.092 12.6 0.3 1.5 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF3447 PF11929.8 EFO64236.1 - 0.057 13.4 0.1 0.54 10.3 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3447) SPACA9 PF15120.6 EFO64236.1 - 0.067 13.0 0.1 0.18 11.5 0.1 1.7 1 0 0 1 1 1 0 Sperm acrosome-associated protein 9 TSC22 PF01166.18 EFO64236.1 - 0.11 12.9 1.7 0.88 9.9 0.9 2.9 2 1 0 2 2 2 0 TSC-22/dip/bun family Kinase-like PF14531.6 EFO64236.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Sec2p PF06428.11 EFO64236.1 - 0.17 11.9 1.1 0.42 10.6 0.3 2.1 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p bZIP_1 PF00170.21 EFO64236.1 - 0.22 11.6 2.3 0.92 9.7 2.1 2.3 1 1 0 1 1 1 0 bZIP transcription factor XhlA PF10779.9 EFO64236.1 - 3.9 7.7 5.1 3.7 7.8 0.9 2.6 2 0 0 2 2 2 0 Haemolysin XhlA WD40 PF00400.32 EFO64238.1 - 0.023 15.5 6.0 1.7 9.6 0.0 5.9 6 0 0 6 6 6 0 WD domain, G-beta repeat KcnmB2_inactiv PF09303.10 EFO64239.1 - 0.033 14.0 0.1 0.093 12.5 0.1 1.7 1 0 0 1 1 1 0 KCNMB2, ball and chain domain RNA_pol_Rpb2_6 PF00562.28 EFO64240.1 - 5.5e-114 381.3 0.0 8.1e-114 380.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EFO64240.1 - 1.1e-39 136.0 0.0 1.6e-39 135.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EFO64240.1 - 2.9e-27 94.9 0.2 7.4e-27 93.6 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 EFO64240.1 - 2.4e-18 66.2 0.1 5.4e-18 65.0 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EFO64240.1 - 5.3e-17 61.8 0.0 1.2e-16 60.7 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 EFO64240.1 - 2.7e-14 53.2 0.1 9.2e-11 41.7 0.1 2.6 2 0 0 2 2 2 2 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_5 PF04567.17 EFO64240.1 - 6e-08 33.1 0.3 1.7e-07 31.7 0.3 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Ank_2 PF12796.7 EFO64242.1 - 2.3e-19 69.7 0.1 8.4e-11 42.3 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64242.1 - 4.8e-14 52.1 1.0 0.0032 17.8 0.0 4.9 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EFO64242.1 - 2e-13 49.2 0.5 0.017 15.6 0.0 5.1 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 EFO64242.1 - 1.1e-12 47.9 3.3 0.0027 18.0 0.1 5.1 3 1 3 6 6 6 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64242.1 - 3.2e-08 33.9 2.6 0.0015 19.1 0.1 4.7 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO64242.1 - 0.24 10.8 0.0 6.5 6.0 0.0 2.3 2 0 0 2 2 2 0 Protein kinase domain VSP PF03302.13 EFO64243.1 - 5.3e-37 127.6 73.7 5.3e-37 127.6 73.7 2.1 2 0 0 2 2 2 2 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO64243.1 - 3.6e-07 30.3 98.2 0.0039 17.3 13.2 7.6 1 1 6 7 7 7 5 Furin-like repeat, cysteine-rich TMEM154 PF15102.6 EFO64243.1 - 0.001 19.0 0.1 0.0017 18.3 0.1 1.2 1 0 0 1 1 1 1 TMEM154 protein family DUF4448 PF14610.6 EFO64243.1 - 0.066 13.0 0.2 0.12 12.1 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) MCR PF18509.1 EFO64243.1 - 0.11 12.1 0.1 0.11 12.1 0.1 5.5 7 0 0 7 7 7 0 Magnetochrome domain DUF2569 PF10754.9 EFO64244.1 - 0.02 15.3 1.8 0.041 14.3 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) DUF1700 PF08006.11 EFO64244.1 - 1.2 8.6 4.4 0.63 9.5 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) SPC12 PF06645.13 EFO64244.1 - 6.2 7.0 17.7 0.98 9.6 1.1 3.6 3 1 0 3 3 3 0 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF998 PF06197.13 EFO64244.1 - 7.2 6.2 17.7 2.8 7.5 12.7 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF998) DUF2569 PF10754.9 EFO64245.1 - 0.0061 17.0 2.1 0.14 12.6 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2569) Tim17 PF02466.19 EFO64245.1 - 0.46 10.9 5.1 1.1 9.7 2.6 2.8 2 2 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family CytB6-F_Fe-S PF08802.10 EFO64245.1 - 2 8.5 4.0 2 8.5 0.2 2.5 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit SNARE PF05739.19 EFO64247.1 - 0.0064 16.5 2.8 0.0064 16.5 2.8 1.8 2 0 0 2 2 2 1 SNARE domain Synaptobrevin PF00957.21 EFO64247.1 - 0.01 15.6 3.8 0.026 14.3 3.8 1.7 1 0 0 1 1 1 1 Synaptobrevin DUF720 PF05302.11 EFO64247.1 - 0.17 11.7 0.1 0.17 11.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF720) EMP24_GP25L PF01105.24 EFO64247.1 - 0.37 10.7 2.9 0.95 9.4 2.9 1.7 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Pkinase PF00069.25 EFO64249.1 - 3.6e-21 75.7 0.0 4.8e-21 75.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64249.1 - 4e-14 52.5 0.0 5.2e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.16 EFO64249.1 - 0.064 13.4 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 ABC1 family OTCace PF00185.24 EFO64250.1 - 1.3e-51 174.8 0.0 2.4e-51 173.9 0.0 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 EFO64250.1 - 3e-40 137.7 0.1 4.1e-40 137.2 0.1 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain SMC_N PF02463.19 EFO64251.1 - 2.5e-40 138.3 0.0 5.4e-40 137.2 0.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EFO64251.1 - 5.6e-14 52.6 23.2 2.7e-11 43.8 11.6 3.5 2 1 0 2 2 2 2 AAA ATPase domain SMC_hinge PF06470.13 EFO64251.1 - 4.2e-13 49.6 0.0 1.9e-12 47.5 0.0 2.2 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EFO64251.1 - 1.3e-09 38.3 3.1 0.00076 19.4 0.0 3.0 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFO64251.1 - 0.0032 18.0 60.9 0.016 15.7 30.2 5.6 3 2 0 3 3 3 1 AAA domain APG6_N PF17675.1 EFO64251.1 - 0.049 14.2 0.6 0.049 14.2 0.6 8.3 3 2 3 7 7 7 0 Apg6 coiled-coil region ABC_tran PF00005.27 EFO64251.1 - 0.17 12.4 0.0 0.17 12.4 0.0 5.6 4 1 0 4 4 4 0 ABC transporter Vps23_core PF09454.10 EFO64251.1 - 4.1 7.4 6.4 5.9 6.9 0.0 4.2 5 0 0 5 5 5 0 Vps23 core domain EGF_2 PF07974.13 EFO64252.1 - 1.4e-12 47.8 254.1 0.0017 18.7 11.3 20.0 18 2 1 19 19 19 11 EGF-like domain EGF PF00008.27 EFO64252.1 - 0.0001 22.6 219.1 0.087 13.2 3.1 19.1 17 2 0 17 17 17 13 EGF-like domain EGF_Tenascin PF18720.1 EFO64252.1 - 0.006 16.6 9.8 0.006 16.6 9.8 19.9 16 5 3 19 19 19 6 Tenascin EGF domain EphA2_TM PF14575.6 EFO64252.1 - 0.072 14.0 0.0 0.18 12.7 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ank_2 PF12796.7 EFO64254.1 - 5.7e-85 280.0 3.8 2.9e-17 63.0 0.1 5.3 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64254.1 - 3.4e-43 145.5 7.5 1.1e-10 41.8 0.3 7.8 6 3 2 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO64254.1 - 6.3e-40 133.9 0.1 0.00027 21.2 0.0 9.8 10 0 0 10 10 10 8 Ankyrin repeat Ank_5 PF13857.6 EFO64254.1 - 3.4e-38 129.2 10.4 1.4e-05 25.2 0.0 8.5 1 1 7 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64254.1 - 1.8e-33 110.8 0.3 0.0016 18.8 0.0 9.8 10 0 0 10 10 10 7 Ankyrin repeat T3SSipB PF16535.5 EFO64254.1 - 0.55 10.7 4.5 0.87 10.1 4.5 1.2 1 0 0 1 1 1 0 Type III cell invasion protein SipB DUF2894 PF11445.8 EFO64254.1 - 1.5 9.2 5.1 2.3 8.7 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) Ank_2 PF12796.7 EFO64255.1 - 3.4e-94 309.6 34.3 1.4e-11 44.8 0.1 13.5 4 3 11 15 15 15 15 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64255.1 - 1.9e-50 168.3 37.6 0.00014 22.1 0.0 20.7 8 6 14 22 22 22 17 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64255.1 - 5e-49 164.1 25.0 9.1e-05 22.9 0.1 16.0 14 4 4 18 18 18 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64255.1 - 1.7e-45 147.7 30.9 0.048 14.2 0.0 21.5 22 0 0 22 22 22 15 Ankyrin repeat Ank PF00023.30 EFO64255.1 - 3.7e-42 141.0 38.1 0.035 14.5 0.0 19.8 17 4 4 21 21 21 12 Ankyrin repeat Coatamer_beta_C PF07718.12 EFO64256.1 - 6.1e-17 61.8 0.1 1.2e-16 60.9 0.1 1.4 1 0 0 1 1 1 1 Coatomer beta C-terminal region Adaptin_N PF01602.20 EFO64256.1 - 6.3e-16 58.0 0.2 6.3e-16 58.0 0.2 2.0 2 0 0 2 2 2 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 EFO64256.1 - 1e-11 44.9 0.0 2e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform HEAT PF02985.22 EFO64256.1 - 0.019 15.2 1.1 0.83 10.1 0.0 3.8 4 0 0 4 4 4 0 HEAT repeat Arm PF00514.23 EFO64256.1 - 0.088 12.9 0.1 9.2 6.5 0.0 3.8 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFO64256.1 - 0.17 12.5 0.1 1.3 9.6 0.0 2.6 2 0 0 2 2 2 0 HEAT-like repeat LRR_6 PF13516.6 EFO64257.1 - 0.051 13.6 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 Leucine Rich repeat WD40 PF00400.32 EFO64258.1 - 5.5e-12 46.0 6.6 0.099 13.6 0.0 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat ELYS-bb PF16687.5 EFO64258.1 - 0.13 10.9 0.0 0.18 10.3 0.0 1.2 1 0 0 1 1 1 0 beta-propeller of ELYS nucleoporin Prenyltransf PF01255.19 EFO64259.1 - 3.5e-72 242.6 0.0 4.1e-72 242.4 0.0 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase PEPCK_GTP PF00821.18 EFO64260.1 - 4.9e-99 331.6 0.0 6.1e-99 331.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain PEPCK_N PF17297.2 EFO64260.1 - 1.9e-55 187.9 0.0 2.8e-55 187.3 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase N-terminal domain PEPCK_ATP PF01293.20 EFO64260.1 - 0.00025 19.9 0.0 0.00041 19.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase CCT PF06203.14 EFO64261.1 - 1.3e-06 28.3 1.0 2.1e-06 27.7 1.0 1.3 1 0 0 1 1 1 1 CCT motif Ank_2 PF12796.7 EFO64262.1 - 1.5e-117 384.4 57.3 2.4e-11 44.0 0.1 17.4 5 4 12 18 18 18 18 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64262.1 - 8.7e-57 188.5 40.0 0.0006 20.1 0.0 23.8 16 6 11 27 27 27 15 Ankyrin repeats (many copies) Ank PF00023.30 EFO64262.1 - 6.9e-53 174.9 27.4 0.02 15.4 0.1 24.3 26 0 0 26 26 26 12 Ankyrin repeat Ank_4 PF13637.6 EFO64262.1 - 5.8e-51 170.3 30.6 2.8e-08 34.2 0.1 20.7 13 8 9 23 23 23 12 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64262.1 - 6.5e-51 164.4 35.8 0.0067 16.8 0.0 26.5 29 0 0 29 29 29 12 Ankyrin repeat Nop25 PF09805.9 EFO64263.1 - 2.7e-10 40.9 16.6 3.5e-10 40.5 16.6 1.1 1 0 0 1 1 1 1 Nucleolar protein 12 (25kDa) TIP49_C PF17856.1 EFO64263.1 - 0.046 13.8 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 TIP49 AAA-lid domain Peptidase_C58 PF03543.14 EFO64263.1 - 0.071 12.8 2.9 0.088 12.5 2.9 1.2 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen Atg14 PF10186.9 EFO64263.1 - 0.92 8.5 13.3 1.1 8.2 13.3 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 EFO64263.1 - 1.1 8.6 6.6 1.3 8.4 6.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2040 PF09745.9 EFO64263.1 - 2.1 8.4 17.7 1.4 8.9 11.5 2.3 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 55 (DUF2040) Ank_2 PF12796.7 EFO64265.1 - 7.6e-89 292.4 34.7 3.4e-16 59.6 0.4 11.0 3 2 9 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64265.1 - 1.9e-47 159.0 31.1 3.4e-06 27.5 0.1 15.7 11 4 4 15 15 15 14 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64265.1 - 1.5e-39 129.4 28.4 0.00022 21.4 0.0 19.1 20 0 0 20 20 20 11 Ankyrin repeat Ank PF00023.30 EFO64265.1 - 2.9e-39 131.8 31.1 0.0022 18.4 0.0 18.7 18 2 2 20 20 20 13 Ankyrin repeat Ank_5 PF13857.6 EFO64265.1 - 6.5e-38 128.3 41.6 0.00015 22.0 0.1 17.8 7 4 11 19 19 19 13 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFO64266.1 - 6.1e-73 241.4 12.2 7.3e-15 55.3 0.1 10.2 2 2 6 9 9 9 8 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64266.1 - 5.5e-36 121.5 24.4 0.0058 17.0 0.0 15.6 14 1 2 16 16 16 10 Ankyrin repeat Ank_3 PF13606.6 EFO64266.1 - 8.6e-34 111.8 20.1 0.066 13.8 0.0 17.2 19 0 0 19 19 19 8 Ankyrin repeat Ank_4 PF13637.6 EFO64266.1 - 5.1e-30 103.5 18.2 0.0001 22.8 0.1 12.0 9 2 4 13 13 13 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO64266.1 - 8.5e-27 92.9 23.0 0.0026 18.0 0.0 14.4 8 3 8 16 16 16 8 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO64266.1 - 0.1 11.9 0.1 1.3 8.3 0.0 2.5 2 0 0 2 2 2 0 Protein kinase domain Ank_2 PF12796.7 EFO64267.1 - 1.6e-22 79.9 0.2 1.7e-10 41.3 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64267.1 - 1.3e-13 50.7 4.7 0.0026 18.1 0.0 4.6 4 1 1 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EFO64267.1 - 5.3e-12 45.7 1.5 0.00029 21.1 0.0 4.5 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64267.1 - 1.4e-11 44.6 1.1 4.7e-05 23.9 0.0 4.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64267.1 - 2.3e-11 42.9 0.2 0.0024 18.2 0.0 5.1 5 0 0 5 5 5 2 Ankyrin repeat DEK_C PF08766.11 EFO64267.1 - 0.64 10.0 2.8 0.47 10.4 0.6 2.0 2 0 0 2 2 2 0 DEK C terminal domain KxDL PF10241.9 EFO64268.1 - 0.051 13.9 4.3 1.2 9.5 2.6 2.7 1 1 1 2 2 2 0 Uncharacterized conserved protein FlhC PF05280.11 EFO64268.1 - 0.058 13.1 2.2 0.14 11.9 0.1 2.1 2 0 0 2 2 2 0 Flagellar transcriptional activator (FlhC) Spectrin PF00435.21 EFO64268.1 - 0.087 13.3 0.6 0.087 13.3 0.6 2.3 2 0 0 2 2 2 0 Spectrin repeat tRNA-synt_1e PF01406.19 EFO64268.1 - 0.18 11.1 0.3 0.27 10.5 0.3 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain FlaC_arch PF05377.11 EFO64268.1 - 0.23 11.8 2.1 1.4 9.4 0.2 2.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) LIF_OSM PF01291.17 EFO64268.1 - 1.1 9.3 4.1 3.1 7.9 0.3 2.3 1 1 0 2 2 2 0 LIF / OSM family Snapin_Pallidin PF14712.6 EFO64268.1 - 2 8.9 6.9 1.9 8.9 1.9 2.9 1 1 1 2 2 2 0 Snapin/Pallidin Fib_alpha PF08702.10 EFO64268.1 - 2.8 8.1 5.0 6.9 6.9 3.5 2.4 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF16 PF01519.16 EFO64268.1 - 3.9 8.0 6.4 2.9 8.4 1.9 2.5 1 1 1 2 2 2 0 Protein of unknown function DUF16 Pkinase PF00069.25 EFO64269.1 - 2.8e-37 128.5 0.0 3.7e-37 128.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64269.1 - 1.2e-20 73.9 0.0 1.8e-20 73.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFO64269.1 - 0.074 11.8 0.0 0.13 11.0 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Myb_DNA-binding PF00249.31 EFO64271.1 - 1.1e-05 25.5 0.0 1.6e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Ank_2 PF12796.7 EFO64274.1 - 6.1e-47 158.1 7.1 1.5e-08 35.1 0.1 6.9 2 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64274.1 - 4.5e-29 100.1 8.3 0.002 18.4 0.0 8.4 4 3 3 8 8 8 8 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64274.1 - 3.8e-25 87.9 5.5 0.00054 20.5 0.1 10.2 6 2 4 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64274.1 - 6.1e-23 78.4 2.3 0.17 12.5 0.0 10.0 10 0 0 10 10 9 5 Ankyrin repeat Ank PF00023.30 EFO64274.1 - 1.2e-21 76.1 3.4 0.0088 16.5 0.0 10.5 11 0 0 11 11 11 4 Ankyrin repeat YabA PF06156.13 EFO64274.1 - 0.02 15.5 17.2 0.49 11.0 2.4 3.8 3 0 0 3 3 3 0 Initiation control protein YabA PKcGMP_CC PF16808.5 EFO64274.1 - 0.042 13.7 5.4 0.1 12.5 0.1 3.3 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase SpoOE-like PF09388.10 EFO64274.1 - 0.17 11.8 8.1 5 7.1 0.3 4.0 3 0 0 3 3 3 0 Spo0E like sporulation regulatory protein ADIP PF11559.8 EFO64274.1 - 0.18 11.9 22.7 0.15 12.2 6.5 3.7 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding Shugoshin_N PF07558.11 EFO64274.1 - 0.21 11.5 4.1 0.2 11.6 1.6 2.4 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region DUF573 PF04504.14 EFO64274.1 - 0.51 11.0 3.1 0.66 10.7 1.0 2.4 2 0 0 2 2 1 0 Protein of unknown function, DUF573 Cnn_1N PF07989.11 EFO64274.1 - 2.8 8.2 19.8 0.72 10.1 4.2 4.1 3 1 0 3 3 3 0 Centrosomin N-terminal motif 1 CH_2 PF06294.11 EFO64275.1 - 0.088 12.9 0.0 0.49 10.5 0.0 2.4 2 0 0 2 2 2 0 CH-like domain in sperm protein DUF4032 PF13224.6 EFO64275.1 - 0.096 12.6 0.1 0.24 11.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4032) bZIP_1 PF00170.21 EFO64275.1 - 0.38 10.9 6.1 13 6.0 0.1 3.9 3 0 0 3 3 3 0 bZIP transcription factor KASH_CCD PF14662.6 EFO64275.1 - 1.1 9.1 7.5 0.17 11.7 2.6 2.2 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH HIP1_clath_bdg PF16515.5 EFO64275.1 - 1.3 9.6 7.5 2 9.1 0.3 4.2 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fimbrial PF00419.20 EFO64275.1 - 2.1 8.6 12.8 3.4 7.9 1.4 3.3 3 0 0 3 3 3 0 Fimbrial protein RasGAP_C PF03836.15 EFO64275.1 - 6.8 6.8 15.2 0.69 10.1 2.4 4.7 2 1 2 4 4 4 0 RasGAP C-terminus Ank_2 PF12796.7 EFO64276.1 - 4.4e-49 165.0 6.4 9.6e-13 48.5 0.2 6.7 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO64276.1 - 1.9e-23 80.0 13.9 0.043 14.4 0.0 11.6 12 0 0 12 12 12 6 Ankyrin repeat Ank_5 PF13857.6 EFO64276.1 - 2.2e-23 82.0 14.2 9e-05 22.7 0.0 10.4 3 3 8 11 11 11 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64276.1 - 1.1e-18 67.3 10.1 0.0026 18.3 0.0 8.4 7 2 1 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO64276.1 - 6e-15 54.9 13.8 0.002 18.5 0.0 9.4 10 1 0 10 10 10 3 Ankyrin repeat IQ PF00612.27 EFO64279.1 - 1.6e-08 33.6 12.7 0.003 17.2 0.8 4.2 4 0 0 4 4 4 3 IQ calmodulin-binding motif Ank_2 PF12796.7 EFO64282.1 - 2.1e-47 159.6 24.5 5.1e-11 43.0 0.3 9.6 3 2 8 11 11 11 11 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64282.1 - 4.3e-29 100.5 12.0 1.4e-05 25.5 0.2 11.5 8 4 4 12 12 12 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64282.1 - 4.6e-22 75.7 25.0 0.0026 18.1 0.0 14.9 16 0 0 16 16 16 6 Ankyrin repeat Ank PF00023.30 EFO64282.1 - 1.6e-21 75.7 24.1 0.0024 18.3 0.0 14.5 16 1 0 16 16 16 4 Ankyrin repeat Ank_5 PF13857.6 EFO64282.1 - 8e-21 73.8 23.3 6.7e-05 23.1 0.2 14.9 8 5 9 17 17 17 5 Ankyrin repeats (many copies) zf-C3HC4_3 PF13920.6 EFO64282.1 - 9.9e-11 41.3 13.8 9.9e-11 41.3 13.8 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO64282.1 - 0.00033 20.5 13.9 0.00081 19.2 13.9 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 AbbA_antirepres PF14156.6 EFO64282.1 - 1.1 9.2 5.6 21 5.1 0.1 3.8 4 0 0 4 4 4 0 Antirepressor AbbA zf-RING_5 PF14634.6 EFO64282.1 - 3.3 7.7 15.1 8.7 6.4 15.1 1.8 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFO64282.1 - 5.3 7.0 16.8 17 5.4 16.8 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RTC PF01137.21 EFO64283.1 - 3e-30 105.1 0.0 3.6e-30 104.8 0.0 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 EFO64283.1 - 1.4e-17 64.1 0.0 3.1e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain MFS_1 PF07690.16 EFO64284.1 - 9.8e-23 80.6 60.8 2e-21 76.3 59.9 3.0 2 1 0 2 2 2 2 Major Facilitator Superfamily TMEM169 PF15052.6 EFO64285.1 - 0.64 10.1 5.7 0.83 9.8 4.1 1.9 1 1 1 2 2 2 0 TMEM169 protein family Fzo_mitofusin PF04799.13 EFO64286.1 - 0.019 14.5 2.5 3.9 7.0 1.2 2.2 2 0 0 2 2 2 0 fzo-like conserved region bZIP_2 PF07716.15 EFO64286.1 - 0.45 10.6 2.9 0.99 9.5 2.9 1.6 1 0 0 1 1 1 0 Basic region leucine zipper bZIP_1 PF00170.21 EFO64286.1 - 0.93 9.6 4.7 0.78 9.9 1.4 2.6 3 1 0 3 3 3 0 bZIP transcription factor Ank_2 PF12796.7 EFO64287.1 - 2.5e-84 277.9 37.3 1.5e-14 54.3 0.5 8.6 2 2 9 11 11 11 11 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO64287.1 - 2.8e-40 131.7 14.7 0.036 14.6 0.0 13.6 13 0 0 13 13 13 12 Ankyrin repeat Ank PF00023.30 EFO64287.1 - 3.8e-40 134.6 21.7 0.012 16.1 0.0 13.4 13 1 0 13 13 13 12 Ankyrin repeat Ank_4 PF13637.6 EFO64287.1 - 4.6e-40 135.5 16.3 3.3e-06 27.5 0.1 10.5 9 4 2 11 11 11 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO64287.1 - 6e-40 134.8 23.6 0.00012 22.3 0.0 12.7 4 3 9 13 13 13 10 Ankyrin repeats (many copies) COE1_DBD PF16422.5 EFO64287.1 - 0.0033 16.9 0.7 0.74 9.2 0.0 3.0 4 0 0 4 4 4 2 Transcription factor COE1 DNA-binding domain Talin_middle PF09141.10 EFO64287.1 - 0.22 11.5 3.6 2.9 7.9 0.1 3.4 2 1 1 3 3 3 0 Talin, middle domain Paramecium_SA PF01508.16 EFO64287.1 - 0.22 11.9 1.5 0.3 11.6 0.2 1.8 2 0 0 2 2 2 0 Paramecium surface antigen domain Peptidase_C1 PF00112.23 EFO64288.1 - 4.3e-31 108.7 1.1 1.9e-30 106.6 1.1 2.0 1 1 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFO64288.1 - 8.3e-05 21.5 0.1 0.0014 17.5 0.1 2.1 2 0 0 2 2 2 1 Peptidase C1-like family LapA_dom PF06305.11 EFO64288.1 - 0.016 15.0 2.3 0.042 13.6 2.3 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain EpmC PF04315.12 EFO64288.1 - 0.061 13.0 0.4 1.8 8.3 1.4 2.2 2 0 0 2 2 2 0 Elongation factor P hydroxylase Glycophorin_A PF01102.18 EFO64288.1 - 0.078 13.2 0.2 0.14 12.4 0.2 1.3 1 0 0 1 1 1 0 Glycophorin A Insulin_TMD PF17870.1 EFO64288.1 - 0.57 10.3 4.5 0.78 9.9 2.7 2.1 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment Syndecan PF01034.20 EFO64288.1 - 3.7 7.5 4.7 7.8 6.5 4.7 1.5 1 0 0 1 1 1 0 Syndecan domain Ribosomal_S8e PF01201.22 EFO64289.1 - 4.2e-43 146.8 0.8 4.8e-43 146.6 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e DUF2334 PF10096.9 EFO64290.1 - 0.11 12.2 0.1 0.26 10.9 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) DUF4029 PF13221.6 EFO64291.1 - 5.6 7.7 11.2 0.12 13.0 1.5 2.7 2 2 0 2 2 2 0 Protein of unknown function (DUF4029) TP53IP5 PF15331.6 EFO64292.1 - 0.49 10.5 10.0 1.3 9.2 10.0 1.7 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 HAD_2 PF13419.6 EFO64293.1 - 1.7e-28 99.9 0.0 2.4e-28 99.4 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFO64293.1 - 2.4e-12 47.6 0.0 7.7e-10 39.4 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase NIF PF03031.18 EFO64293.1 - 0.0014 18.5 0.0 0.0075 16.0 0.0 2.0 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 EFO64293.1 - 0.0023 18.4 0.1 0.004 17.6 0.1 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EFO64293.1 - 0.017 15.3 0.1 9 6.5 0.0 2.9 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFO64293.1 - 0.039 14.0 0.0 0.068 13.2 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like VSP PF03302.13 EFO64295.1 - 1.7e-39 135.8 176.8 8.9e-31 107.1 67.7 8.1 1 1 7 8 8 8 6 Giardia variant-specific surface protein Profilin PF00235.19 EFO64295.1 - 0.017 15.4 0.2 0.065 13.5 0.2 2.0 1 0 0 1 1 1 0 Profilin VSP PF03302.13 EFO64296.1 - 1.5e-41 142.6 196.4 2.7e-28 99.0 75.1 5.7 1 1 2 3 3 3 3 Giardia variant-specific surface protein MFS_1 PF07690.16 EFO64298.1 - 3.9e-08 32.6 49.3 0.00032 19.8 38.4 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TIG_plexin PF17960.1 EFO64298.1 - 0.058 13.4 0.1 0.16 12.0 0.1 1.7 1 0 0 1 1 1 0 TIG domain Fe_hyd_lg_C PF02906.14 EFO64299.1 - 3.8e-63 213.4 0.1 5.1e-63 213.0 0.1 1.1 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Fer4_21 PF14697.6 EFO64299.1 - 9e-11 41.7 9.5 2.7e-10 40.2 9.5 1.8 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4 PF00037.27 EFO64299.1 - 3.5e-10 39.2 22.3 2.9e-07 30.0 3.4 3.0 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_7 PF12838.7 EFO64299.1 - 4.7e-09 36.7 6.8 4.7e-09 36.7 6.8 2.3 2 0 0 2 2 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 EFO64299.1 - 3.9e-08 33.3 8.2 3.9e-08 33.3 8.2 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 EFO64299.1 - 8.3e-08 32.0 15.7 0.00063 19.7 4.0 2.8 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 EFO64299.1 - 2.6e-07 31.5 8.7 4.5e-05 24.3 0.3 3.0 3 0 0 3 3 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 EFO64299.1 - 6.3e-06 26.2 6.3 0.00069 19.7 0.4 3.0 4 0 0 4 4 3 2 4Fe-4S dicluster domain Fer4_22 PF17179.4 EFO64299.1 - 2.8e-05 24.9 2.5 0.11 13.3 0.4 2.7 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 EFO64299.1 - 0.00023 21.1 18.3 0.011 15.8 2.8 3.2 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4_8 PF13183.6 EFO64299.1 - 0.00063 20.1 10.0 0.01 16.3 10.5 2.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 EFO64299.1 - 0.00072 20.0 10.6 0.0088 16.6 10.6 2.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fe_hyd_SSU PF02256.17 EFO64299.1 - 0.0066 16.5 4.1 0.0066 16.5 4.1 2.3 2 1 0 2 2 2 1 Iron hydrogenase small subunit Fer4_4 PF12800.7 EFO64299.1 - 0.0076 16.7 2.7 0.0076 16.7 2.7 3.5 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4_3 PF12798.7 EFO64299.1 - 0.039 14.9 5.3 0.039 14.9 5.3 3.4 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_15 PF13459.6 EFO64299.1 - 0.066 14.0 12.9 0.6 10.9 0.4 3.0 3 0 0 3 3 2 0 4Fe-4S single cluster domain Fer4_13 PF13370.6 EFO64299.1 - 0.15 12.7 11.9 2.9 8.5 1.3 2.6 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.6 EFO64299.1 - 0.98 9.6 14.4 2.4 8.4 2.8 2.6 1 1 1 2 2 2 0 4Fe-4S dicluster domain Ank_2 PF12796.7 EFO64300.1 - 1.1e-07 32.3 0.2 0.0021 18.6 0.0 4.2 1 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO64300.1 - 0.00014 22.0 0.1 4 8.3 0.0 4.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 EFO64301.1 - 1.7e-46 156.7 5.8 1.5e-10 41.6 0.3 6.3 3 3 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO64301.1 - 1.9e-23 80.0 8.8 0.0063 16.9 0.0 12.0 12 0 0 12 12 12 5 Ankyrin repeat Ank_4 PF13637.6 EFO64301.1 - 2.3e-22 79.1 6.8 0.0015 19.0 0.0 9.5 7 3 3 10 10 10 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO64301.1 - 3.1e-18 65.3 14.2 0.0094 16.4 0.0 11.6 12 1 0 12 12 12 5 Ankyrin repeat Ank_5 PF13857.6 EFO64301.1 - 6.6e-18 64.5 11.6 0.0041 17.4 0.0 9.9 7 1 4 11 11 11 6 Ankyrin repeats (many copies) TPR_12 PF13424.6 EFO64302.1 - 0.052 13.8 0.0 11 6.4 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Hema_stalk PF08720.10 EFO64304.1 - 0.005 16.6 0.1 0.0079 15.9 0.1 1.3 1 0 0 1 1 1 1 Influenza C hemagglutinin stalk WASH_WAHD PF11945.8 EFO64304.1 - 0.008 15.7 1.7 0.015 14.9 1.7 1.5 1 0 0 1 1 1 1 WAHD domain of WASH complex Snapin_Pallidin PF14712.6 EFO64304.1 - 0.14 12.6 2.1 2.6 8.5 0.1 2.7 1 1 1 2 2 2 0 Snapin/Pallidin Ribosomal_L17 PF01196.19 EFO64304.1 - 0.15 13.0 3.7 0.95 10.4 0.6 2.4 1 1 1 2 2 2 0 Ribosomal protein L17 DUF2278 PF10042.9 EFO64304.1 - 0.15 12.0 0.2 0.26 11.3 0.2 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2278) PI3K_P85_iSH2 PF16454.5 EFO64304.1 - 0.2 11.2 2.0 0.69 9.5 0.1 2.2 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain RMMBL PF07521.12 EFO64305.1 - 0.042 13.8 0.0 6.3 6.8 0.0 2.4 2 0 0 2 2 2 0 Zn-dependent metallo-hydrolase RNA specificity domain Fe-ADH PF00465.19 EFO64305.1 - 0.12 11.2 0.0 0.38 9.5 0.0 1.7 2 0 0 2 2 2 0 Iron-containing alcohol dehydrogenase IFT81_CH PF18383.1 EFO64306.1 - 6.6e-09 36.1 0.9 7.1e-08 32.7 0.0 2.8 2 0 0 2 2 2 1 Intraflagellar transport 81 calponin homology domain APG6_N PF17675.1 EFO64306.1 - 0.0027 18.2 5.4 0.0027 18.2 5.4 5.5 3 2 1 4 4 4 2 Apg6 coiled-coil region FlxA PF14282.6 EFO64306.1 - 0.0093 15.9 2.8 0.0093 15.9 2.8 5.4 3 2 1 4 4 4 2 FlxA-like protein COMMD1_N PF17221.3 EFO64306.1 - 0.092 13.1 2.8 0.59 10.4 0.2 3.0 2 0 0 2 2 2 0 COMMD1 N-terminal domain Bap31_Bap29_C PF18035.1 EFO64306.1 - 2.7 8.0 17.3 0.63 10.1 0.8 5.7 4 1 0 4 4 4 0 Bap31/Bap29 cytoplasmic coiled-coil domain Sugar_tr PF00083.24 EFO64307.1 - 1.3e-81 274.8 27.2 1.7e-81 274.4 27.2 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFO64307.1 - 2.6e-24 85.8 35.0 4.6e-23 81.7 31.0 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFO64307.1 - 0.0059 15.2 49.2 0.0057 15.3 13.0 4.2 3 2 2 5 5 5 4 MFS/sugar transport protein Herpes_LMP1 PF05297.11 EFO64307.1 - 0.05 12.8 12.1 0.12 11.6 12.1 1.6 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) GSH_synth_ATP PF03917.17 EFO64308.1 - 2e-26 92.7 0.0 1.3e-25 90.0 0.0 1.8 1 1 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 EFO64308.1 - 2.1e-12 47.4 0.0 4.4e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Pkinase PF00069.25 EFO64309.1 - 1.2e-75 254.3 0.0 1.4e-75 254.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64309.1 - 4.1e-34 118.0 0.0 9.2e-34 116.9 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO64309.1 - 0.0068 15.8 0.1 3 7.1 0.1 2.2 1 1 1 2 2 2 2 Kinase-like RIO1 PF01163.22 EFO64309.1 - 0.0088 15.7 0.1 0.014 15.0 0.1 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EFO64309.1 - 0.024 14.5 0.0 0.13 12.2 0.0 1.9 1 1 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFO64309.1 - 0.089 11.7 0.0 0.85 8.5 0.0 2.1 1 1 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 EFO64309.1 - 0.093 11.8 0.0 0.22 10.5 0.0 1.6 2 0 0 2 2 2 0 Seadornavirus VP7 Shugoshin_N PF07558.11 EFO64311.1 - 0.04 13.8 0.3 0.19 11.7 0.3 2.2 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region YjbH PF06082.11 EFO64311.1 - 0.36 9.6 5.8 0.47 9.2 5.8 1.2 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH NusB PF01029.18 EFO64311.1 - 0.37 11.0 4.3 2.3 8.5 0.3 2.6 1 1 1 2 2 2 0 NusB family FlaC_arch PF05377.11 EFO64311.1 - 0.63 10.5 4.0 2.6 8.5 0.2 3.4 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF21 PF01595.20 EFO64313.1 - 8.2e-31 107.0 4.0 1.2e-30 106.5 4.0 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EFO64313.1 - 4.6e-07 30.2 0.0 0.084 13.3 0.0 3.1 2 1 0 2 2 2 2 CBS domain YrhC PF14143.6 EFO64313.1 - 0.079 13.1 1.7 0.2 11.8 1.7 1.7 1 0 0 1 1 1 0 YrhC-like protein Pkinase PF00069.25 EFO64314.1 - 4.8e-37 127.7 0.0 7.1e-37 127.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64314.1 - 2.3e-27 95.9 0.0 3.3e-27 95.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4051 PF13260.6 EFO64314.1 - 0.1 12.3 0.1 0.19 11.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) DHC_N2 PF08393.13 EFO64315.1 - 9.8e-122 406.9 9.6 9.8e-122 406.9 9.6 4.7 6 1 0 6 6 6 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 EFO64315.1 - 6.8e-118 394.7 23.4 7.6e-84 282.3 5.8 3.6 3 0 0 3 3 3 2 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 EFO64315.1 - 3.4e-81 272.8 0.2 7.9e-81 271.6 0.2 1.6 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region AAA PF00004.29 EFO64315.1 - 0.00094 19.6 0.1 0.0094 16.4 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFO64315.1 - 0.084 12.9 0.1 2.2 8.3 0.0 3.3 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EFO64315.1 - 0.11 13.1 0.4 0.98 10.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain YkyA PF10368.9 EFO64315.1 - 9.2 5.9 9.5 4.1 7.0 4.3 3.1 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Ufm1 PF03671.14 EFO64319.1 - 4.8e-26 90.6 0.1 6.2e-26 90.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein VPS28 PF03997.12 EFO64320.1 - 0.13 12.0 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 VPS28 protein TPR_12 PF13424.6 EFO64320.1 - 0.19 12.0 5.8 0.55 10.6 1.3 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF4770 PF15994.5 EFO64321.1 - 0.11 12.7 0.1 0.17 12.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) T3SS_LEE_assoc PF13327.6 EFO64323.1 - 0.15 12.1 0.0 0.54 10.3 0.0 1.8 2 0 0 2 2 2 0 Type III secretion system subunit Ysc84 PF04366.12 EFO64323.1 - 0.15 11.8 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Las17-binding protein actin regulator Ank_2 PF12796.7 EFO64324.1 - 4.4e-61 203.5 15.0 2.1e-13 50.7 0.4 7.1 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64324.1 - 1.1e-39 134.3 8.3 6.5e-07 29.8 0.0 8.9 8 3 3 11 11 11 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64324.1 - 1.5e-35 117.1 4.6 0.0027 18.1 0.0 11.3 11 0 0 11 11 11 9 Ankyrin repeat Pkinase PF00069.25 EFO64324.1 - 1.1e-33 116.8 0.0 1.1e-32 113.5 0.0 2.5 3 0 0 3 3 3 1 Protein kinase domain Ank_5 PF13857.6 EFO64324.1 - 3.2e-31 107.0 12.7 4.6e-05 23.6 0.0 9.5 5 3 4 9 9 9 8 Ankyrin repeats (many copies) Ank PF00023.30 EFO64324.1 - 4.1e-28 96.6 3.9 0.015 15.7 0.0 10.7 11 0 0 11 11 11 7 Ankyrin repeat Pkinase_Tyr PF07714.17 EFO64324.1 - 2e-23 83.0 0.0 1.5e-22 80.1 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase Sigma70_ner PF04546.13 EFO64324.1 - 0.067 13.1 0.2 0.15 11.9 0.2 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF3704 PF12488.8 EFO64325.1 - 0.056 13.1 0.0 0.095 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) DUF2802 PF10975.8 EFO64325.1 - 0.11 12.7 0.2 0.25 11.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) Kinesin PF00225.23 EFO64327.1 - 3.6e-95 318.7 0.7 4.8e-95 318.3 0.7 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFO64327.1 - 3.9e-18 65.8 0.2 9.6e-18 64.6 0.2 1.7 1 0 0 1 1 1 1 Microtubule binding SAM_1 PF00536.30 EFO64327.1 - 1.8e-07 31.5 0.1 5.5e-07 29.9 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFO64327.1 - 2.5e-06 27.5 0.0 5.5e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RTP1_C2 PF10304.9 EFO64327.1 - 0.0054 16.4 1.4 0.015 14.9 1.4 1.9 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 Ribosomal_L1 PF00687.21 EFO64328.1 - 6.5e-11 42.4 0.1 2e-10 40.8 0.1 1.7 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family Pox_TAA1 PF03295.14 EFO64330.1 - 0.021 14.7 0.1 0.14 12.1 0.0 2.1 1 1 1 2 2 2 0 Poxvirus trans-activator protein A1 C-terminal SYCP2_ARLD PF18581.1 EFO64331.1 - 0.031 14.3 0.4 0.1 12.6 0.4 1.8 1 0 0 1 1 1 0 Synaptonemal complex 2 armadillo-repeat-like domain Methyltransf_4 PF02390.17 EFO64332.1 - 1.3e-29 102.8 0.0 2e-29 102.2 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 EFO64332.1 - 0.059 14.1 0.0 0.27 12.0 0.0 2.2 3 1 0 3 3 3 0 Methyltransferase domain Methyltransf_2 PF00891.18 EFO64332.1 - 0.1 11.9 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain Ank_2 PF12796.7 EFO64333.1 - 2.1e-70 233.3 29.9 1.3e-11 44.9 0.0 9.0 2 2 8 10 10 10 10 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64333.1 - 2.8e-40 135.1 24.5 0.0016 18.8 0.1 15.6 14 2 0 14 14 14 10 Ankyrin repeat Ank_5 PF13857.6 EFO64333.1 - 4.4e-40 135.2 27.8 0.0019 18.4 0.1 14.2 6 3 8 14 14 14 10 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64333.1 - 1.1e-38 131.1 17.7 3.5e-06 27.4 0.1 10.4 7 4 4 12 12 12 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64333.1 - 7.9e-33 108.8 13.9 0.045 14.3 0.0 14.9 15 0 0 15 15 15 10 Ankyrin repeat Pkinase PF00069.25 EFO64333.1 - 3.7e-20 72.4 0.0 7.7e-20 71.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64333.1 - 2.9e-10 39.9 0.0 4.6e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EGF_2 PF07974.13 EFO64334.1 - 4.2e-11 43.0 66.4 7.1e-05 23.1 9.7 6.8 5 1 1 6 6 6 4 EGF-like domain EB PF01683.18 EFO64334.1 - 0.00011 22.4 4.7 0.00011 22.4 4.7 6.7 2 2 2 4 4 4 3 EB module EGF PF00008.27 EFO64334.1 - 0.2 12.0 62.2 0.16 12.3 6.2 7.5 4 4 3 7 7 7 0 EGF-like domain Fer4_9 PF13187.6 EFO64335.1 - 4.2e-09 36.4 8.6 4.9e-09 36.2 8.6 1.1 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EFO64335.1 - 1.7e-07 31.7 10.1 3.2e-07 30.8 10.2 1.4 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4 PF00037.27 EFO64335.1 - 1.4e-06 27.9 15.9 0.00095 18.9 3.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 EFO64335.1 - 6.1e-06 27.1 8.0 0.0083 17.0 1.2 2.1 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 EFO64335.1 - 7.2e-06 26.0 10.7 8.6e-06 25.8 10.7 1.1 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 EFO64335.1 - 7.5e-06 25.8 14.1 0.00032 20.6 2.2 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 EFO64335.1 - 6.3e-05 22.8 12.4 0.0033 17.4 2.1 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 EFO64335.1 - 8.6e-05 22.6 9.9 0.00017 21.6 10.1 1.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 EFO64335.1 - 0.00038 20.9 10.7 0.16 12.5 10.7 2.1 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_4 PF12800.7 EFO64335.1 - 0.0055 17.1 12.3 0.36 11.4 3.5 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_22 PF17179.4 EFO64335.1 - 0.0058 17.4 9.0 0.29 12.0 0.5 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.7 EFO64335.1 - 0.064 14.2 17.9 1.1 10.3 4.4 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_8 PF13183.6 EFO64335.1 - 0.11 13.0 12.2 6 7.4 12.3 2.0 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 EFO64335.1 - 6.6 7.0 11.0 18 5.6 11.0 1.7 1 1 0 1 1 1 0 4Fe-4S dicluster domain Syntaxin PF00804.25 EFO64336.1 - 3e-13 49.9 14.3 3e-13 49.9 14.3 1.6 2 1 0 2 2 2 1 Syntaxin SNARE PF05739.19 EFO64336.1 - 1.7e-10 40.8 2.1 1.9e-10 40.6 0.3 2.1 2 0 0 2 2 2 1 SNARE domain baeRF_family2 PF18844.1 EFO64336.1 - 0.012 15.7 0.4 0.023 14.8 0.4 1.6 1 1 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 2 INTS5_N PF14837.6 EFO64336.1 - 0.012 15.2 1.7 0.026 14.1 1.7 1.6 1 0 0 1 1 1 0 Integrator complex subunit 5 N-terminus Syntaxin-6_N PF09177.11 EFO64336.1 - 0.08 13.5 11.6 0.94 10.1 0.7 3.1 1 1 2 3 3 3 0 Syntaxin 6, N-terminal Retrotrans_gag PF03732.17 EFO64336.1 - 0.082 13.2 4.4 4.4 7.6 0.3 3.3 2 1 1 3 3 3 0 Retrotransposon gag protein FOXP-CC PF16159.5 EFO64336.1 - 0.14 12.8 6.1 1.1 9.9 2.6 2.8 2 0 0 2 2 2 0 FOXP coiled-coil domain Laminin_II PF06009.12 EFO64336.1 - 0.18 11.8 12.5 0.9 9.5 1.9 3.0 2 1 1 3 3 3 0 Laminin Domain II Vir_act_alpha_C PF10400.9 EFO64336.1 - 0.19 12.4 3.1 0.28 11.9 0.5 2.4 1 1 1 2 2 2 0 Virulence activator alpha C-term CreD PF06123.12 EFO64336.1 - 0.43 9.3 3.3 0.63 8.8 3.3 1.2 1 0 0 1 1 1 0 Inner membrane protein CreD RP-C_C PF11800.8 EFO64336.1 - 1.2 9.1 11.8 3.3 7.7 2.5 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region OmpH PF03938.14 EFO64336.1 - 1.8 8.9 20.6 2.5 8.5 6.6 2.6 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) HsbA PF12296.8 EFO64336.1 - 3.8 8.0 10.3 13 6.2 3.6 3.8 2 1 0 3 3 3 0 Hydrophobic surface binding protein A MCPsignal PF00015.21 EFO64336.1 - 9.6 6.0 13.8 0.87 9.4 2.3 2.7 1 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Ost5 PF05251.12 EFO64337.1 - 0.1 12.9 0.2 0.18 12.1 0.2 1.3 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit 5 Ribul_P_3_epim PF00834.19 EFO64338.1 - 8e-62 208.2 0.0 4.3e-30 104.6 0.0 2.0 2 0 0 2 2 2 2 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 EFO64338.1 - 0.0016 18.2 0.0 0.0084 15.9 0.0 1.9 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, C-terminal domain His_Phos_2 PF00328.22 EFO64340.1 - 3.7e-40 138.4 0.0 2.2e-29 103.0 0.0 4.1 3 1 0 3 3 3 3 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EFO64340.1 - 7.5e-26 90.1 0.0 2.1e-25 88.7 0.0 1.8 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EFO64340.1 - 0.034 13.7 0.0 0.081 12.5 0.0 1.6 1 0 0 1 1 1 0 RimK-like ATP-grasp domain YppG PF14179.6 EFO64340.1 - 0.1 13.3 0.0 7.6 7.3 0.0 3.0 2 0 0 2 2 2 0 YppG-like protein Pkinase PF00069.25 EFO64341.1 - 1.2e-50 172.3 0.0 7.8e-33 113.9 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64341.1 - 4.2e-26 91.8 0.0 2e-18 66.6 0.0 3.0 3 0 0 3 3 3 2 Protein tyrosine kinase PH_3 PF14593.6 EFO64341.1 - 4.2e-12 46.1 0.1 1.1e-11 44.8 0.1 1.7 1 0 0 1 1 1 1 PH domain Kdo PF06293.14 EFO64341.1 - 0.0012 18.2 0.0 0.0057 16.0 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFO64341.1 - 0.016 14.0 0.3 0.097 11.4 0.0 2.3 3 0 0 3 3 3 0 Fungal protein kinase APH PF01636.23 EFO64341.1 - 0.023 14.6 0.0 0.064 13.2 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family zinc-ribbons_6 PF07191.12 EFO64341.1 - 0.054 13.5 0.2 0.054 13.5 0.2 3.0 3 0 0 3 3 3 0 zinc-ribbons FYVE PF01363.21 EFO64341.1 - 0.93 9.7 6.0 5.1 7.3 2.8 2.7 2 0 0 2 2 2 0 FYVE zinc finger Ank_2 PF12796.7 EFO64342.1 - 2e-62 207.7 10.4 1.7e-10 41.3 0.0 7.3 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64342.1 - 2e-34 117.2 6.2 0.00013 22.1 0.1 9.7 4 3 6 10 10 10 8 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64342.1 - 6e-32 109.6 11.2 5.1e-06 26.9 0.0 8.6 4 2 8 12 12 12 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64342.1 - 1.8e-29 98.5 11.5 0.0023 18.3 0.0 12.2 12 0 0 12 12 12 8 Ankyrin repeat Ank PF00023.30 EFO64342.1 - 7.6e-29 98.9 14.9 0.00091 19.6 0.0 12.2 11 2 0 11 11 11 7 Ankyrin repeat Ribosomal_L27e PF01777.18 EFO64344.1 - 6e-23 81.0 0.5 8.3e-23 80.6 0.5 1.1 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 EFO64344.1 - 2e-05 24.4 0.0 4.2e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 KOW motif HALZ PF02183.18 EFO64345.1 - 0.018 15.3 28.4 0.067 13.4 1.4 5.7 5 1 0 5 5 5 0 Homeobox associated leucine zipper Spc7 PF08317.11 EFO64345.1 - 0.045 12.6 36.4 0.034 13.0 15.2 2.7 2 1 1 3 3 3 0 Spc7 kinetochore protein FlaC_arch PF05377.11 EFO64345.1 - 0.27 11.7 15.4 0.46 10.9 0.2 4.9 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) Snapin_Pallidin PF14712.6 EFO64345.1 - 0.29 11.6 25.3 0.069 13.6 6.3 4.6 4 1 1 5 5 5 0 Snapin/Pallidin TolA_bind_tri PF16331.5 EFO64345.1 - 0.38 10.8 17.2 4.5 7.4 5.2 4.4 3 1 0 3 3 3 0 TolA binding protein trimerisation HMMR_C PF15908.5 EFO64345.1 - 0.74 10.1 21.0 1.3 9.3 4.0 4.7 3 2 1 4 4 4 0 Hyaluronan mediated motility receptor C-terminal DUF2681 PF10883.8 EFO64345.1 - 1.1 9.7 12.5 1.9 9.0 0.4 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) CCDC92 PF14916.6 EFO64345.1 - 1.7 8.5 7.4 0.13 12.1 0.2 2.9 3 0 0 3 3 3 0 Coiled-coil domain of unknown function WD40_alt PF14077.6 EFO64345.1 - 3.8 7.4 7.8 1.4 8.8 0.4 3.3 3 0 0 3 3 3 0 Alternative WD40 repeat motif GAS PF13851.6 EFO64345.1 - 5.6 6.2 40.7 3.8 6.8 14.1 4.0 2 2 1 3 3 3 0 Growth-arrest specific micro-tubule binding FUSC PF04632.12 EFO64345.1 - 8.2 4.8 8.0 4.8 5.6 4.4 2.0 1 1 1 2 2 2 0 Fusaric acid resistance protein family Ank_2 PF12796.7 EFO64346.1 - 9.3e-54 180.0 13.7 1.3e-14 54.5 0.2 5.4 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64346.1 - 3.6e-26 91.2 1.9 9.6e-08 32.4 0.0 5.7 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO64346.1 - 5.2e-21 74.4 8.7 2.4e-06 27.7 0.0 7.7 2 2 5 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO64346.1 - 1.2e-20 73.0 1.5 0.02 15.3 0.0 8.4 8 0 0 8 8 8 6 Ankyrin repeat Ank_3 PF13606.6 EFO64346.1 - 1.9e-12 46.2 12.7 0.023 15.2 0.0 8.2 10 0 0 10 10 10 4 Ankyrin repeat Herpes_LMP1 PF05297.11 EFO64346.1 - 5.7 6.0 6.4 13 4.8 1.9 2.5 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) IFT57 PF10498.9 EFO64347.1 - 7.7e-70 235.7 0.0 8.8e-70 235.5 0.0 1.0 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 DUF1664 PF07889.12 EFO64347.1 - 0.001 19.1 0.3 0.0028 17.7 0.2 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1664) Laminin_II PF06009.12 EFO64347.1 - 0.0098 15.9 0.8 0.022 14.7 0.8 1.7 1 0 0 1 1 1 1 Laminin Domain II ATG16 PF08614.11 EFO64347.1 - 0.013 15.8 1.4 0.019 15.2 1.4 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Seryl_tRNA_N PF02403.22 EFO64347.1 - 0.024 14.9 0.4 0.059 13.6 0.4 1.7 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain TMF_DNA_bd PF12329.8 EFO64347.1 - 0.031 14.3 0.2 0.11 12.6 0.2 1.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding MAD PF05557.13 EFO64347.1 - 0.049 12.0 0.5 0.067 11.6 0.5 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein Myosin_tail_1 PF01576.19 EFO64347.1 - 0.054 11.3 1.4 0.067 11.0 1.4 1.0 1 0 0 1 1 1 0 Myosin tail MscS_porin PF12795.7 EFO64347.1 - 0.065 12.8 3.3 0.1 12.1 3.3 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Bacillus_HBL PF05791.11 EFO64347.1 - 0.07 13.0 1.3 8.1 6.2 0.7 2.5 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Spc7 PF08317.11 EFO64347.1 - 0.075 11.9 0.5 0.11 11.3 0.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Snapin_Pallidin PF14712.6 EFO64347.1 - 0.088 13.2 0.4 0.21 12.0 0.1 1.8 2 0 0 2 2 1 0 Snapin/Pallidin Fmp27_WPPW PF10359.9 EFO64347.1 - 0.16 10.8 0.7 0.22 10.3 0.7 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain TPR_MLP1_2 PF07926.12 EFO64347.1 - 0.19 11.8 2.1 1.5 8.9 1.4 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein TTL PF03133.15 EFO64348.1 - 5.6e-51 173.4 0.1 9.6e-50 169.4 0.1 2.2 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EFO64348.1 - 2.9e-06 26.7 0.2 0.0011 18.3 0.1 2.5 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EFO64348.1 - 0.005 16.1 0.0 0.049 12.9 0.1 2.3 2 1 0 2 2 2 1 Sugar-transfer associated ATP-grasp GARS_A PF01071.19 EFO64348.1 - 0.0096 15.7 0.0 0.043 13.6 0.0 2.0 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain AFT PF08731.11 EFO64348.1 - 0.43 11.0 2.2 0.4 11.1 0.1 2.0 2 0 0 2 2 2 0 Transcription factor AFT WD40 PF00400.32 EFO64349.1 - 0.00013 22.7 0.3 0.31 12.0 0.0 3.7 3 0 0 3 3 3 1 WD domain, G-beta repeat Elicitin PF00964.17 EFO64349.1 - 0.051 13.7 0.1 0.11 12.6 0.1 1.6 1 0 0 1 1 1 0 Elicitin DUF2935 PF11155.8 EFO64350.1 - 1 9.7 8.6 13 6.2 3.4 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF2935) Baculo_PEP_C PF04513.12 EFO64350.1 - 2.3 8.2 12.9 2.1 8.4 0.4 2.7 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Kelch_4 PF13418.6 EFO64352.1 - 3.9e-22 78.0 4.2 5.3e-09 35.9 0.0 6.1 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EFO64352.1 - 7.2e-11 41.8 5.7 0.014 15.4 0.4 5.0 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 EFO64352.1 - 1.6e-09 37.7 8.1 0.0036 17.5 0.1 4.6 4 1 1 5 5 5 3 Kelch motif Kelch_1 PF01344.25 EFO64352.1 - 4.2e-05 23.0 6.9 0.16 11.6 0.1 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 EFO64352.1 - 9.7e-05 22.6 5.5 1.7 9.0 0.0 5.2 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EFO64352.1 - 0.07 13.1 5.7 17 5.6 0.1 4.4 5 0 0 5 5 5 0 Kelch motif Herpes_BMRF2 PF04633.12 EFO64352.1 - 0.15 11.3 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus BMRF2 protein Aminotran_1_2 PF00155.21 EFO64353.1 - 1.6e-68 231.6 0.0 1.8e-68 231.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II zf-C3HC4_2 PF13923.6 EFO64354.1 - 0.00027 20.7 4.5 0.00027 20.7 4.5 5.4 7 0 0 7 7 7 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFO64354.1 - 0.00041 20.1 8.9 0.00041 20.1 8.9 4.9 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFO64354.1 - 0.0036 17.1 10.0 0.0036 17.1 10.0 3.9 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFO64354.1 - 0.014 15.7 9.6 0.014 15.7 9.6 4.2 3 2 1 4 4 4 0 Ring finger domain SUIM_assoc PF16619.5 EFO64354.1 - 0.014 15.4 1.9 0.063 13.4 1.9 2.1 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 zf-RING_5 PF14634.6 EFO64354.1 - 0.015 15.2 10.6 0.015 15.2 10.6 3.9 3 1 1 4 4 4 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFO64354.1 - 0.017 15.2 8.9 0.017 15.2 8.9 4.0 5 0 0 5 5 5 0 RING-type zinc-finger PapB PF03333.13 EFO64354.1 - 0.12 12.4 0.2 0.27 11.3 0.2 1.5 1 0 0 1 1 1 0 Adhesin biosynthesis transcription regulatory protein zf-C2H2_3rep PF18868.1 EFO64354.1 - 0.57 10.9 15.4 0.72 10.5 0.9 3.2 2 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats Prok-RING_4 PF14447.6 EFO64354.1 - 8.4 6.3 21.3 1.2 9.1 7.3 4.1 4 0 0 4 4 4 0 Prokaryotic RING finger family 4 Proteasome PF00227.26 EFO64356.1 - 4e-46 156.9 0.8 4.7e-46 156.7 0.8 1.1 1 0 0 1 1 1 1 Proteasome subunit MORN PF02493.20 EFO64357.1 - 7.6e-17 60.1 32.5 2.2e-05 24.0 1.7 6.1 6 0 0 6 6 6 5 MORN repeat Methyltransf_31 PF13847.6 EFO64358.1 - 5.9e-13 48.9 0.0 7.6e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFO64358.1 - 3.6e-12 46.8 0.0 1.2e-11 45.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFO64358.1 - 4.7e-11 43.2 0.0 2.7e-10 40.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFO64358.1 - 1.2e-07 31.3 0.1 2e-07 30.6 0.1 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EFO64358.1 - 1.4e-06 28.2 0.0 1.9e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFO64358.1 - 1.9e-06 28.6 0.0 4.9e-06 27.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_29 PF03141.16 EFO64358.1 - 0.077 11.5 0.0 0.097 11.2 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase AlbA_2 PF04326.14 EFO64359.1 - 9.3e-12 45.4 0.0 1.5e-11 44.7 0.0 1.3 1 0 0 1 1 1 1 Putative DNA-binding domain Ins_P5_2-kin PF06090.12 EFO64360.1 - 0.06 12.8 0.1 0.079 12.4 0.1 1.2 1 0 0 1 1 1 0 Inositol-pentakisphosphate 2-kinase DUF1360 PF07098.11 EFO64361.1 - 0.09 12.7 1.0 0.19 11.7 0.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1360) DUF3021 PF11457.8 EFO64361.1 - 0.17 12.2 8.2 0.52 10.6 8.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3021) NYD-SP28 PF14772.6 EFO64362.1 - 2.2e-08 34.1 4.3 2.2e-08 34.1 4.3 4.9 3 1 1 5 5 5 1 Sperm tail RcsC PF09456.10 EFO64362.1 - 0.0039 17.1 2.9 1.4 8.9 0.0 3.2 3 0 0 3 3 3 2 RcsC Alpha-Beta-Loop (ABL) DUF268 PF03269.14 EFO64362.1 - 0.0044 16.9 0.3 0.36 10.7 0.0 2.5 2 0 0 2 2 2 1 Caenorhabditis protein of unknown function, DUF268 TNF PF00229.18 EFO64362.1 - 0.066 13.2 4.4 0.044 13.7 1.3 2.2 2 2 1 3 3 3 0 TNF(Tumour Necrosis Factor) family Octopine_DH PF02317.17 EFO64362.1 - 0.11 12.5 1.2 0.4 10.8 1.1 2.0 1 1 0 1 1 1 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain AI-2E_transport PF01594.16 EFO64362.1 - 0.46 9.6 3.8 0.54 9.3 2.3 1.9 2 0 0 2 2 2 0 AI-2E family transporter UT PF03253.14 EFO64363.1 - 0.21 10.7 0.0 0.28 10.3 0.0 1.1 1 0 0 1 1 1 0 Urea transporter Tir_receptor_N PF07490.11 EFO64364.1 - 0.093 12.6 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) N-terminus zf-C2H2_4 PF13894.6 EFO64365.1 - 8.2e-07 29.3 8.8 0.12 13.3 1.0 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFO64365.1 - 4.9e-06 26.7 2.5 0.011 16.0 0.9 3.2 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFO64365.1 - 4.9e-05 23.6 3.9 0.48 10.9 0.0 3.4 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_9 PF16293.5 EFO64365.1 - 0.00051 19.8 5.6 0.042 13.7 0.1 3.3 3 0 0 3 3 3 1 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 EFO64365.1 - 0.00053 20.3 4.8 1.3 9.4 1.3 3.4 2 1 1 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EFO64365.1 - 0.0018 18.6 11.7 1.2 9.8 0.0 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type Zn-C2H2_12 PF18112.1 EFO64365.1 - 0.013 15.9 3.9 0.73 10.3 0.4 3.2 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain zf-Di19 PF05605.12 EFO64365.1 - 0.027 14.7 8.4 1.4 9.3 0.3 3.4 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_6 PF18450.1 EFO64365.1 - 0.25 11.1 1.5 2.7 7.8 0.2 2.4 2 0 0 2 2 2 0 Zinc Finger domain zf-C2H2_11 PF16622.5 EFO64365.1 - 0.42 10.4 11.3 0.084 12.7 1.1 3.0 3 0 0 3 3 3 0 zinc-finger C2H2-type AAA_6 PF12774.7 EFO64367.1 - 1.8e-47 161.9 4.7 1.1e-33 116.6 0.1 4.1 4 1 0 4 4 4 2 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFO64367.1 - 3.2e-34 118.7 0.7 3.2e-34 118.7 0.7 3.3 4 0 0 4 4 3 1 Dynein heavy chain, N-terminal region 2 MT PF12777.7 EFO64367.1 - 4.4e-25 88.4 12.9 7.9e-25 87.6 12.9 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_9 PF12781.7 EFO64367.1 - 2.7e-15 56.1 16.4 2e-08 33.6 0.0 4.2 4 0 0 4 4 4 2 ATP-binding dynein motor region AAA_5 PF07728.14 EFO64367.1 - 7.7e-08 32.4 1.2 0.0027 17.7 0.0 4.9 4 1 0 4 4 4 2 AAA domain (dynein-related subfamily) Dynein_C PF18199.1 EFO64367.1 - 0.00021 20.6 0.0 0.00021 20.6 0.0 3.7 5 0 0 5 5 4 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 EFO64367.1 - 0.00091 19.1 0.1 0.0024 17.7 0.1 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 EFO64367.1 - 0.001 19.1 0.0 0.0054 16.8 0.0 2.3 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain AAA PF00004.29 EFO64367.1 - 0.003 18.0 0.0 0.012 16.0 0.0 2.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Dynein_AAA_lid PF17852.1 EFO64367.1 - 0.037 14.1 0.0 0.2 11.7 0.0 2.3 1 0 0 1 1 1 0 Dynein heavy chain AAA lid domain AAA_7 PF12775.7 EFO64367.1 - 0.046 13.2 0.0 0.38 10.2 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region Exonuc_VII_L PF02601.15 EFO64367.1 - 6.6 6.2 15.6 1.7 8.2 6.9 3.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit EGF_2 PF07974.13 EFO64369.1 - 3.2e-20 72.2 163.3 2.7e-05 24.4 5.7 11.6 11 1 0 11 11 11 10 EGF-like domain EGF PF00008.27 EFO64369.1 - 1.2e-06 28.6 12.5 0.00015 22.0 2.1 12.2 12 2 0 12 12 12 8 EGF-like domain PG_binding_4 PF12229.8 EFO64370.1 - 0.099 12.9 0.1 0.17 12.2 0.1 1.3 1 0 0 1 1 1 0 Putative peptidoglycan binding domain HMMR_N PF15905.5 EFO64371.1 - 0.067 12.7 36.7 0.25 10.8 18.0 2.5 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal FlxA PF14282.6 EFO64371.1 - 0.13 12.2 25.1 0.33 11.0 0.5 4.9 3 1 1 4 4 4 0 FlxA-like protein Golgin_A5 PF09787.9 EFO64371.1 - 0.13 11.7 34.4 2.2 7.7 17.8 2.6 1 1 1 2 2 2 0 Golgin subfamily A member 5 Vps5 PF09325.10 EFO64371.1 - 0.16 11.5 20.9 2.1 7.9 17.0 3.4 1 1 0 2 2 2 0 Vps5 C terminal like Baculo_PEP_C PF04513.12 EFO64371.1 - 0.3 11.1 18.0 3.2 7.8 7.0 3.9 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlaC_arch PF05377.11 EFO64371.1 - 0.32 11.4 0.1 0.32 11.4 0.1 5.6 4 1 2 6 6 6 0 Flagella accessory protein C (FlaC) CALCOCO1 PF07888.11 EFO64371.1 - 0.52 9.1 35.9 0.56 9.0 34.3 1.8 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF812 PF05667.11 EFO64371.1 - 0.62 8.9 34.8 0.39 9.6 30.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Csm1_N PF18504.1 EFO64371.1 - 1.4 9.3 37.6 3.9 7.9 2.2 7.0 4 2 2 7 7 7 0 Csm1 N-terminal domain Yuri_gagarin PF15934.5 EFO64371.1 - 1.6 8.6 21.1 0.37 10.6 17.5 1.8 2 0 0 2 2 2 0 Yuri gagarin APC_N_CC PF16689.5 EFO64371.1 - 1.6 8.9 7.8 4.7 7.3 0.1 4.1 3 1 1 4 4 3 0 Coiled-coil N-terminus of APC, dimerisation domain Filament PF00038.21 EFO64371.1 - 2.8 7.4 38.5 35 3.8 30.4 3.6 2 1 1 3 3 3 0 Intermediate filament protein Laminin_II PF06009.12 EFO64371.1 - 2.8 7.9 23.2 0.81 9.7 5.2 2.9 1 1 0 2 2 2 0 Laminin Domain II DUF4618 PF15397.6 EFO64371.1 - 3 7.2 32.7 7.2 6.0 27.9 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) NPV_P10 PF05531.12 EFO64371.1 - 3.1 8.3 16.7 34 5.0 0.5 5.3 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein Atg14 PF10186.9 EFO64371.1 - 3.3 6.7 25.7 1.8 7.5 7.6 2.9 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fez1 PF06818.15 EFO64371.1 - 5.9 7.3 33.8 1.6 9.2 16.2 2.6 1 1 1 2 2 2 0 Fez1 DUF4407 PF14362.6 EFO64371.1 - 6.2 6.1 29.9 1.2e+04 -4.7 29.8 3.0 1 1 0 1 1 0 0 Domain of unknown function (DUF4407) ADIP PF11559.8 EFO64371.1 - 8.8 6.4 33.7 6 6.9 8.1 4.9 3 1 2 5 5 5 0 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.9 EFO64371.1 - 9.4 6.3 43.2 0.25 11.4 12.1 4.0 1 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TBK1_ULD PF18396.1 EFO64373.1 - 0.034 14.1 0.0 0.06 13.3 0.0 1.5 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain DUF1764 PF08576.10 EFO64374.1 - 3.3e-20 72.8 2.6 4.1e-20 72.5 2.6 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF1764) Auxin_repressed PF05564.12 EFO64376.1 - 0.98 10.1 6.8 0.34 11.6 1.3 2.5 1 1 1 2 2 2 0 Dormancy/auxin associated protein Helicase_C PF00271.31 EFO64377.1 - 7.9e-12 45.5 0.0 1.9e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFO64377.1 - 9.6e-12 45.0 0.0 1.1e-06 28.6 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 EFO64377.1 - 2.3e-05 24.5 0.0 4.7e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 EFO64377.1 - 0.013 14.8 0.0 0.35 10.1 0.0 2.1 2 0 0 2 2 2 0 SecA DEAD-like domain Peptidase_C1 PF00112.23 EFO64378.1 - 1.1e-31 110.6 1.0 4.6e-19 69.4 1.5 3.3 2 1 1 3 3 3 3 Papain family cysteine protease Pkinase PF00069.25 EFO64379.1 - 3.1e-29 102.1 0.1 4.7e-29 101.5 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64379.1 - 2.8e-14 53.0 0.1 5.6e-14 52.0 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFO64380.1 - 1.3e-23 83.7 0.0 2.1e-23 83.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64380.1 - 3.3e-16 59.4 0.0 5.1e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3854 PF12965.7 EFO64380.1 - 0.12 12.4 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3854) Pkinase PF00069.25 EFO64381.1 - 1.8e-18 66.8 0.0 2.5e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64381.1 - 7.2e-09 35.3 0.0 2.1e-08 33.8 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFO64382.1 - 3.1e-17 62.8 0.0 5e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64382.1 - 9.1e-05 21.9 0.0 0.00031 20.1 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO64382.1 - 0.0012 18.2 0.1 0.21 10.9 0.0 2.2 2 0 0 2 2 2 2 Kinase-like FPV060 PF17614.2 EFO64382.1 - 0.078 12.4 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Viral CC-type chemokine Pkinase PF00069.25 EFO64383.1 - 7.2e-20 71.4 0.0 1e-19 70.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64383.1 - 8.1e-12 45.0 0.0 1.4e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HMG_CoA_synt_N PF01154.17 EFO64384.1 - 6e-34 117.4 0.2 9.8e-34 116.7 0.2 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 EFO64384.1 - 7.2e-23 81.6 0.2 4.9e-22 78.9 0.2 2.3 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal ACP_syn_III PF08545.10 EFO64384.1 - 0.068 13.0 0.2 0.24 11.3 0.2 1.9 1 1 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PhoQ_Sensor PF08918.10 EFO64385.1 - 0.084 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 PhoQ Sensor DUF373 PF04123.13 EFO64386.1 - 2.4 7.5 5.6 3 7.2 5.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF373) PMP22_Claudin PF00822.20 EFO64387.1 - 0.063 13.2 0.2 0.12 12.2 0.0 1.6 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin family DUF5406 PF17400.2 EFO64387.1 - 0.11 12.9 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5406) Histone PF00125.24 EFO64388.1 - 3.4e-36 124.5 3.9 4.2e-36 124.2 3.9 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EFO64388.1 - 4.8e-09 36.3 0.4 1.4e-07 31.6 0.0 2.2 1 1 1 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EFO64388.1 - 8e-05 23.0 0.5 0.00048 20.5 0.0 2.1 2 0 0 2 2 2 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EFO64388.1 - 0.024 14.9 2.2 0.1 12.9 0.2 2.7 2 2 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PHP_C PF13263.6 EFO64389.1 - 0.13 12.1 0.0 0.33 10.7 0.0 1.7 1 0 0 1 1 1 0 PHP-associated Asn_synthase PF00733.21 EFO64390.1 - 1.9e-10 41.0 0.0 1.4e-05 25.0 0.0 2.2 1 1 1 2 2 2 2 Asparagine synthase zf-RING_UBOX PF13445.6 EFO64391.1 - 3.3e-09 36.6 8.6 6.4e-09 35.7 8.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFO64391.1 - 1.3e-08 34.6 7.0 2.4e-08 33.7 7.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFO64391.1 - 5.8e-08 32.8 9.7 1e-07 32.0 9.7 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EFO64391.1 - 9.2e-08 32.3 8.0 1.9e-07 31.3 8.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFO64391.1 - 1.7e-07 30.9 7.7 4.4e-07 29.6 7.7 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFO64391.1 - 5.5e-07 29.3 10.3 9.6e-07 28.6 10.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFO64391.1 - 3e-06 27.1 8.3 7.2e-06 25.9 8.3 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EFO64391.1 - 1.4e-05 24.9 8.6 2.5e-05 24.0 8.1 1.7 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 EFO64391.1 - 0.0003 20.6 4.6 0.00068 19.5 4.6 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein DUF3450 PF11932.8 EFO64391.1 - 0.023 14.0 1.0 0.039 13.3 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 EFO64391.1 - 0.05 13.7 4.7 0.34 11.0 2.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Rtf2 PF04641.12 EFO64391.1 - 0.054 12.8 4.8 0.12 11.7 4.8 1.7 1 1 0 1 1 1 0 Rtf2 RING-finger Meth_synt_2 PF01717.18 EFO64391.1 - 0.062 12.6 0.1 0.093 12.0 0.1 1.2 1 0 0 1 1 1 0 Cobalamin-independent synthase, Catalytic domain CtIP_N PF10482.9 EFO64391.1 - 0.096 12.7 3.3 0.066 13.3 1.1 1.8 2 0 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain DUF724 PF05266.14 EFO64391.1 - 0.13 12.1 2.4 0.26 11.1 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) zf-rbx1 PF12678.7 EFO64391.1 - 0.21 11.9 6.8 0.83 10.0 6.8 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain Lge1 PF11488.8 EFO64391.1 - 1.1 9.5 5.8 0.35 11.1 1.2 2.3 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 YabA PF06156.13 EFO64391.1 - 2.8 8.6 6.6 23 5.7 2.5 2.8 2 1 1 3 3 3 0 Initiation control protein YabA FYVE PF01363.21 EFO64391.1 - 9.1 6.5 10.7 77 3.5 10.8 2.5 1 1 0 1 1 1 0 FYVE zinc finger dCMP_cyt_deam_1 PF00383.23 EFO64392.1 - 0.00044 20.1 0.1 0.00044 20.1 0.1 2.0 2 1 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFO64392.1 - 0.01 15.6 0.7 0.019 14.7 0.0 1.8 3 0 0 3 3 3 0 MafB19-like deaminase CAF1 PF04857.20 EFO64393.1 - 5.3e-20 71.8 0.3 5.8e-11 42.1 0.0 3.0 1 1 1 2 2 2 2 CAF1 family ribonuclease Myotub-related PF06602.14 EFO64394.1 - 2.7e-81 273.3 0.0 2.7e-55 187.7 0.2 3.0 2 1 0 2 2 2 2 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 EFO64394.1 - 0.018 15.0 0.1 0.042 13.8 0.0 1.6 2 0 0 2 2 2 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 EFO64394.1 - 0.025 14.2 0.1 0.044 13.3 0.1 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DSPc PF00782.20 EFO64394.1 - 0.063 13.1 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain VSP PF03302.13 EFO64395.1 - 5.2e-71 239.6 61.1 9.9e-47 159.6 22.6 2.0 1 1 1 2 2 2 2 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO64395.1 - 0.00052 20.1 0.2 0.00098 19.3 0.2 1.5 1 0 0 1 1 1 1 Podoplanin SKG6 PF08693.10 EFO64395.1 - 0.00068 19.0 3.3 0.0012 18.2 3.3 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 EFO64395.1 - 0.065 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Rax2 PF12768.7 EFO64395.1 - 0.1 12.0 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Ank_2 PF12796.7 EFO64396.1 - 1.6e-39 134.4 6.9 2.2e-11 44.2 0.1 5.3 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64396.1 - 1.2e-18 66.9 7.3 1.6e-06 28.3 0.1 5.7 2 2 4 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO64396.1 - 3.3e-15 55.8 8.1 0.042 14.3 0.0 7.0 7 0 0 7 7 7 4 Ankyrin repeat Ank_3 PF13606.6 EFO64396.1 - 4.3e-15 54.3 8.2 0.11 13.1 0.0 8.5 9 0 0 9 9 9 3 Ankyrin repeat Ank_4 PF13637.6 EFO64396.1 - 6.8e-13 48.9 3.6 1.8e-05 25.2 0.2 5.4 6 0 0 6 6 6 3 Ankyrin repeats (many copies) zf-MYND PF01753.18 EFO64396.1 - 0.45 10.7 1.8 0.39 10.8 0.1 1.7 2 0 0 2 2 2 0 MYND finger LRR_4 PF12799.7 EFO64398.1 - 4.2e-08 33.4 4.1 0.015 15.7 0.0 4.5 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO64398.1 - 1.4e-07 31.2 2.5 0.29 10.9 0.0 5.0 4 1 0 4 4 4 3 Leucine rich repeat LRR_1 PF00560.33 EFO64398.1 - 1.5e-05 24.9 5.7 7.9 7.5 0.0 6.7 5 1 0 5 5 5 1 Leucine Rich Repeat GILT PF03227.16 EFO64398.1 - 8.4e-05 22.8 0.0 0.00017 21.8 0.0 1.6 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) LRR_6 PF13516.6 EFO64398.1 - 0.53 10.5 5.6 40 4.6 0.0 4.9 6 0 0 6 6 6 0 Leucine Rich repeat Transglut_core PF01841.19 EFO64399.1 - 2e-10 41.1 0.0 4.3e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily AAA_8 PF12780.7 EFO64400.1 - 2.4e-96 322.1 0.0 1.2e-94 316.5 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 MT PF12777.7 EFO64400.1 - 6.8e-69 232.5 14.6 1.1e-68 231.8 14.6 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.7 EFO64400.1 - 1.1e-64 217.3 0.0 1.2e-61 207.4 0.0 3.1 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_lid_1 PF17857.1 EFO64400.1 - 2.4e-27 95.0 0.3 1.5e-26 92.5 0.1 2.5 2 0 0 2 2 2 1 AAA+ lid domain Dynein_AAA_lid PF17852.1 EFO64400.1 - 8.5e-25 87.3 0.0 8.2e-24 84.1 0.0 2.5 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_6 PF12774.7 EFO64400.1 - 4.6e-24 85.0 0.1 1.9e-22 79.7 0.0 3.0 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region AAA_5 PF07728.14 EFO64400.1 - 6.2e-19 68.4 0.0 2.7e-09 37.1 0.0 3.8 4 0 0 4 4 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFO64400.1 - 1.3e-06 28.9 0.3 0.0038 17.6 0.0 5.0 4 1 1 5 5 4 1 AAA ATPase domain ABC_tran PF00005.27 EFO64400.1 - 7.3e-05 23.3 3.1 0.024 15.2 0.0 4.1 4 0 0 4 4 4 1 ABC transporter IstB_IS21 PF01695.17 EFO64400.1 - 0.00017 21.4 0.0 0.0071 16.1 0.0 3.1 3 0 0 3 3 2 1 IstB-like ATP binding protein AAA PF00004.29 EFO64400.1 - 0.00042 20.7 0.0 0.21 12.0 0.0 3.4 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EFO64400.1 - 0.00084 19.3 0.0 0.097 12.6 0.0 3.4 3 0 0 3 3 3 1 RsgA GTPase AAA_22 PF13401.6 EFO64400.1 - 0.0015 18.8 1.6 0.32 11.3 0.0 4.4 5 0 0 5 5 4 1 AAA domain DivIVA PF05103.13 EFO64400.1 - 0.0033 17.5 17.9 0.016 15.3 10.6 2.6 2 0 0 2 2 2 1 DivIVA protein ATPase_2 PF01637.18 EFO64400.1 - 0.0044 17.0 4.1 0.025 14.5 0.0 3.3 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_30 PF13604.6 EFO64400.1 - 0.0048 16.6 1.4 0.33 10.7 0.0 3.6 4 0 0 4 4 3 1 AAA domain Roc PF08477.13 EFO64400.1 - 0.0051 17.0 0.2 0.49 10.6 0.0 3.2 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Mg_chelatase PF01078.21 EFO64400.1 - 0.006 16.0 0.0 0.13 11.6 0.0 2.7 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 EFO64400.1 - 0.0083 15.2 0.0 0.032 13.3 0.0 2.0 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_14 PF13173.6 EFO64400.1 - 0.0084 16.1 0.2 2.4 8.2 0.0 3.7 4 0 0 4 4 3 1 AAA domain AAA_35 PF14516.6 EFO64400.1 - 0.013 14.4 0.0 0.025 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_18 PF13238.6 EFO64400.1 - 0.015 15.8 0.1 9.3 6.8 0.0 4.0 4 0 0 4 4 3 0 AAA domain AAA_lid_7 PF17867.1 EFO64400.1 - 0.024 14.8 0.0 0.087 13.0 0.0 2.0 2 0 0 2 2 1 0 Midasin AAA lid domain TsaE PF02367.17 EFO64400.1 - 0.024 14.6 0.1 1 9.3 0.0 3.0 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SRP54 PF00448.22 EFO64400.1 - 0.029 14.0 7.6 3 7.4 0.0 3.8 4 0 0 4 4 3 0 SRP54-type protein, GTPase domain DUF815 PF05673.13 EFO64400.1 - 0.035 13.3 0.0 3 6.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) PduV-EutP PF10662.9 EFO64400.1 - 0.039 13.7 0.1 12 5.6 0.0 3.5 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 EFO64400.1 - 0.041 14.0 2.4 0.16 12.2 0.0 3.0 4 0 0 4 4 2 0 AAA domain AAA_29 PF13555.6 EFO64400.1 - 0.042 13.6 0.1 1.6 8.5 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain PIF1 PF05970.14 EFO64400.1 - 0.051 12.7 0.0 0.8 8.8 0.0 2.4 2 0 0 2 2 2 0 PIF1-like helicase ATP_bind_1 PF03029.17 EFO64400.1 - 0.072 12.9 0.1 1.4 8.6 0.0 3.0 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein NACHT PF05729.12 EFO64400.1 - 0.075 13.0 0.6 0.2 11.5 0.0 2.1 2 0 0 2 2 1 0 NACHT domain RNA_helicase PF00910.22 EFO64400.1 - 0.076 13.4 0.2 1.9 8.9 0.0 2.9 2 0 0 2 2 2 0 RNA helicase AAA_19 PF13245.6 EFO64400.1 - 0.099 13.0 0.5 1.1 9.6 0.0 2.8 3 0 0 3 3 2 0 AAA domain Rad17 PF03215.15 EFO64400.1 - 0.11 12.4 0.0 0.43 10.5 0.0 2.0 1 0 0 1 1 1 0 Rad17 P-loop domain TPR_20 PF14561.6 EFO64400.1 - 0.51 10.7 6.1 0.5 10.7 3.7 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat ALIX_LYPXL_bnd PF13949.6 EFO64400.1 - 0.67 9.2 10.5 0.46 9.7 7.4 2.0 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV G-alpha PF00503.20 EFO64400.1 - 0.68 9.0 2.9 1.3 8.1 0.0 2.8 4 0 0 4 4 3 0 G-protein alpha subunit AAA_23 PF13476.6 EFO64400.1 - 0.75 10.3 12.3 3.6 8.1 0.0 3.1 3 0 0 3 3 3 0 AAA domain FliD_N PF02465.18 EFO64400.1 - 1.5 9.6 8.9 6.1 7.6 0.1 3.6 3 1 1 4 4 3 0 Flagellar hook-associated protein 2 N-terminus Spc7 PF08317.11 EFO64400.1 - 2.5 6.9 17.3 3.8 6.3 11.4 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein CCDC-167 PF15188.6 EFO64400.1 - 5.4 7.4 7.8 11 6.5 0.0 2.8 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Prismane PF03063.20 EFO64401.1 - 4.8e-97 325.8 0.0 5.6e-97 325.6 0.0 1.0 1 0 0 1 1 1 1 Prismane/CO dehydrogenase family Ribosomal_L7Ae PF01248.26 EFO64402.1 - 1e-18 66.9 0.1 1.9e-18 66.0 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF758 PF05527.11 EFO64402.1 - 0.15 12.0 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF758) ELMO_CED12 PF04727.13 EFO64403.1 - 7.3e-14 52.3 0.0 3.1e-13 50.2 0.0 1.8 1 1 0 1 1 1 1 ELMO/CED-12 family EF-hand_1 PF00036.32 EFO64404.1 - 8.3e-18 62.5 0.3 2.3e-06 26.8 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EFO64404.1 - 6.5e-17 60.0 0.1 1.5e-05 24.6 0.0 3.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EFO64404.1 - 6.8e-16 57.0 0.0 0.00091 18.6 0.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EFO64404.1 - 7.5e-14 51.9 0.1 1.1e-08 35.4 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EFO64404.1 - 1.3e-11 44.1 0.4 0.0056 16.5 0.0 3.8 3 1 0 4 4 4 3 EF-hand domain pair EF-hand_14 PF17959.1 EFO64404.1 - 4.1e-05 23.9 0.1 0.0038 17.5 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_9 PF14658.6 EFO64404.1 - 0.0041 17.4 0.1 3.2 8.2 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain Toprim_2 PF13155.6 EFO64404.1 - 0.023 15.1 0.0 3.7 8.1 0.0 2.2 1 1 0 2 2 2 0 Toprim-like Peptidase_C62 PF12380.8 EFO64404.1 - 0.14 11.2 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Gill-associated viral 3C-like peptidase EF-hand_13 PF17958.1 EFO64404.1 - 0.15 11.9 0.0 32 4.4 0.0 2.9 3 1 0 3 3 3 0 EF-hand domain Ank_2 PF12796.7 EFO64405.1 - 1.8e-62 207.9 13.0 4.7e-16 59.1 0.2 4.8 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64405.1 - 2.8e-24 84.4 1.8 0.00015 22.0 0.2 8.0 8 0 0 8 8 8 5 Ankyrin repeat Ank_3 PF13606.6 EFO64405.1 - 1.7e-22 77.1 0.3 0.019 15.5 0.1 8.7 9 0 0 9 9 9 5 Ankyrin repeat Ank_4 PF13637.6 EFO64405.1 - 4.3e-22 78.2 1.0 7.3e-08 32.8 0.1 6.3 6 1 0 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO64405.1 - 1.7e-19 69.6 6.3 0.00014 22.1 0.2 8.1 2 2 6 8 8 8 5 Ankyrin repeats (many copies) DUF5358 PF17311.2 EFO64406.1 - 8 6.4 11.7 0.42 10.6 2.5 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5358) Lipase_GDSL_2 PF13472.6 EFO64408.1 - 7.6e-15 55.8 0.0 9.5e-15 55.4 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFO64408.1 - 8.4e-14 52.0 0.0 1.4e-13 51.3 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF2774 PF11242.8 EFO64408.1 - 0.014 15.6 0.0 0.058 13.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2774) Pkinase PF00069.25 EFO64409.1 - 1.4e-25 90.2 0.0 2.1e-25 89.6 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64409.1 - 8.3e-18 64.6 0.0 1.4e-17 63.9 0.0 1.4 1 1 1 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO64409.1 - 8.5e-06 25.3 0.0 2.6e-05 23.7 0.0 1.7 2 0 0 2 2 2 1 Kinase-like MFS_1 PF07690.16 EFO64410.1 - 1.6e-19 70.1 29.9 1.6e-19 70.1 29.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1772 PF08592.11 EFO64410.1 - 1.4 9.2 11.1 0.12 12.7 2.6 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF1772) Ank_2 PF12796.7 EFO64411.1 - 5.8e-19 68.5 0.0 3.8e-08 33.8 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64411.1 - 7.6e-09 35.7 0.0 4.9e-05 23.5 0.0 3.7 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64411.1 - 6.9e-07 29.1 0.0 3.2 8.6 0.0 4.7 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EFO64411.1 - 1.8e-05 25.2 0.0 2.1 9.0 0.0 4.1 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO64411.1 - 0.00013 22.2 0.2 3.2 8.4 0.0 4.1 4 0 0 4 4 4 1 Ankyrin repeat HAP1_N PF04849.13 EFO64411.1 - 0.0044 16.3 15.3 0.0044 16.3 15.3 3.6 2 1 1 3 3 3 2 HAP1 N-terminal conserved region DUF724 PF05266.14 EFO64411.1 - 0.44 10.4 36.8 0.37 10.6 3.8 4.2 3 1 1 4 4 4 0 Protein of unknown function (DUF724) Tektin PF03148.14 EFO64411.1 - 2.6 6.7 40.9 0.06 12.1 0.9 3.3 2 1 1 3 3 3 0 Tektin family V_ATPase_I PF01496.19 EFO64411.1 - 3.5 5.4 16.4 0.94 7.3 6.6 2.5 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Sec34 PF04136.15 EFO64411.1 - 3.7 7.4 21.4 1.3 8.9 3.8 4.8 3 2 1 4 4 4 0 Sec34-like family GIT_CC PF16559.5 EFO64411.1 - 6.2 6.8 18.4 7.8 6.5 0.9 5.8 5 0 0 5 5 5 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4686 PF15742.5 EFO64411.1 - 6.7 5.7 39.4 0.093 11.9 17.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4686) MscS_porin PF12795.7 EFO64411.1 - 8.7 5.8 50.2 0.21 11.1 22.4 3.6 2 1 1 3 3 3 0 Mechanosensitive ion channel porin domain Pkinase PF00069.25 EFO64412.1 - 5.3e-09 35.8 0.0 9.6e-09 35.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64412.1 - 0.00013 21.4 0.0 0.0009 18.6 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Mad3_BUB1_I PF08311.12 EFO64412.1 - 0.0026 17.8 0.2 0.0058 16.6 0.2 1.5 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 DUF4448 PF14610.6 EFO64413.1 - 0.1 12.4 0.1 0.1 12.4 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) VSP PF03302.13 EFO64415.1 - 1.4e-35 122.9 203.4 1.4e-15 57.1 43.3 6.3 1 1 4 5 5 5 5 Giardia variant-specific surface protein zf-C2H2_4 PF13894.6 EFO64416.1 - 1.7e-07 31.5 8.8 0.072 14.0 1.0 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFO64416.1 - 4.6e-06 26.8 4.3 0.0066 16.7 0.9 3.3 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFO64416.1 - 1.1e-05 25.7 3.9 0.29 11.6 0.0 3.5 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EFO64416.1 - 9.3e-05 22.7 5.4 0.67 10.3 1.4 3.5 2 1 1 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 EFO64416.1 - 0.00012 21.8 5.6 0.026 14.4 0.1 3.3 3 0 0 3 3 3 1 C2H2 type zinc-finger (1 copy) zf-C2H2 PF00096.26 EFO64416.1 - 0.00032 21.0 11.7 0.71 10.4 0.0 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type Zn-C2H2_12 PF18112.1 EFO64416.1 - 0.0033 17.8 3.9 0.46 11.0 0.4 3.3 3 0 0 3 3 3 1 Autophagy receptor zinc finger-C2H2 domain zf-Di19 PF05605.12 EFO64416.1 - 0.0058 16.9 8.4 0.84 10.0 0.3 3.5 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 EFO64416.1 - 0.052 13.3 1.1 0.052 13.3 1.1 3.0 3 0 0 3 3 3 0 zinc-finger C2H2-type zf_C2H2_6 PF18450.1 EFO64416.1 - 0.096 12.4 1.5 1.7 8.4 0.2 2.5 2 0 0 2 2 2 0 Zinc Finger domain GAGA PF09237.11 EFO64416.1 - 1.2 9.0 8.1 0.75 9.6 1.0 3.2 3 0 0 3 3 3 0 GAGA factor zf-C2H2_6 PF13912.6 EFO64416.1 - 2.8 8.0 6.2 19 5.4 0.1 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger zinc_ribbon_9 PF14369.6 EFO64416.1 - 5.9 7.2 7.3 19 5.6 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon zf-H2C2_2 PF13465.6 EFO64416.1 - 7.8 7.1 11.2 19 5.9 3.8 3.8 3 1 0 3 3 3 0 Zinc-finger double domain KH_6 PF15985.5 EFO64417.1 - 0.00016 22.0 0.3 0.00046 20.5 0.1 1.9 2 0 0 2 2 2 1 KH domain EXOSC1 PF10447.9 EFO64417.1 - 0.065 13.8 0.0 0.15 12.6 0.0 1.6 1 0 0 1 1 1 0 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 EFO64417.1 - 0.14 12.0 0.1 0.5 10.2 0.1 1.9 2 0 0 2 2 2 0 Exosome complex exonuclease RRP4 N-terminal region Strep_SA_rep PF06696.11 EFO64419.1 - 2.6e-06 27.2 2.6 2.6e-06 27.2 2.6 4.1 3 0 0 3 3 3 1 Streptococcal surface antigen repeat TFIIS_C PF01096.18 EFO64420.1 - 4.8e-15 55.1 5.0 1e-14 54.1 5.0 1.6 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) TFIIS_M PF07500.14 EFO64420.1 - 5.1e-09 36.6 0.0 1.1e-08 35.5 0.0 1.7 1 1 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain Baculo_LEF5_C PF11792.8 EFO64420.1 - 0.00012 21.7 2.5 0.00026 20.6 2.5 1.6 1 0 0 1 1 1 1 Baculoviridae late expression factor 5 C-terminal domain Cys_rich_KTR PF14205.6 EFO64420.1 - 0.0078 16.0 0.7 0.018 14.8 0.7 1.6 1 0 0 1 1 1 1 Cysteine-rich KTR Zn-ribbon_8 PF09723.10 EFO64420.1 - 0.03 14.4 0.7 3.8 7.7 0.1 2.8 2 0 0 2 2 2 0 Zinc ribbon domain TF_Zn_Ribbon PF08271.12 EFO64420.1 - 0.23 11.0 3.5 0.27 10.8 0.7 2.4 2 1 0 2 2 2 0 TFIIB zinc-binding zinc_ribbon_4 PF13717.6 EFO64420.1 - 2.3 8.2 7.6 43 4.1 7.6 2.5 1 1 1 2 2 2 0 zinc-ribbon domain LRR_4 PF12799.7 EFO64421.1 - 3.2e-11 43.3 4.5 2.3e-06 27.8 0.3 3.0 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO64421.1 - 1.2e-05 24.9 0.4 0.0028 17.4 0.0 2.7 2 0 0 2 2 2 2 Leucine rich repeat LRR_9 PF14580.6 EFO64421.1 - 0.00021 20.8 0.3 0.00094 18.7 0.2 1.9 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 EFO64421.1 - 0.0048 16.9 1.5 76 3.7 0.1 4.7 3 1 1 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 EFO64421.1 - 0.028 14.9 1.3 94 4.2 0.0 4.2 3 1 1 4 4 4 0 Leucine Rich Repeat Pkinase PF00069.25 EFO64422.1 - 1.1e-42 146.3 0.0 4.3e-42 144.3 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64422.1 - 1.8e-30 106.1 0.0 8.5e-30 103.9 0.0 2.2 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFO64422.1 - 2.2e-06 26.7 0.1 5.3e-06 25.5 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Cytokin_check_N PF10407.9 EFO64422.1 - 0.14 12.1 0.1 0.59 10.1 0.1 2.1 1 0 0 1 1 1 0 Cdc14 phosphatase binding protein N-terminus Sec20 PF03908.13 EFO64423.1 - 1.5e-08 34.4 0.2 1.5e-08 34.4 0.2 1.9 3 0 0 3 3 3 1 Sec20 CCDC154 PF15450.6 EFO64423.1 - 0.0013 17.4 2.8 0.0016 17.1 2.8 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 154 TF_AP-2 PF03299.14 EFO64423.1 - 0.037 14.0 0.5 0.056 13.4 0.5 1.3 1 0 0 1 1 1 0 Transcription factor AP-2 Glyco_hydro_42 PF02449.15 EFO64423.1 - 0.21 10.9 0.0 0.26 10.6 0.0 1.1 1 0 0 1 1 1 0 Beta-galactosidase Sugar_tr PF00083.24 EFO64424.1 - 2.8e-36 125.4 14.3 4.9e-36 124.6 14.3 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFO64424.1 - 4.3e-09 35.8 15.0 1.5e-07 30.7 7.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5389 PF17364.2 EFO64424.1 - 0.71 9.9 10.1 1.2 9.3 7.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5389) zf-C4H2 PF10146.9 EFO64425.1 - 0.88 9.8 8.9 1.7 8.9 8.9 1.6 1 1 0 1 1 1 0 Zinc finger-containing protein Csm1_N PF18504.1 EFO64426.1 - 0.054 13.8 0.1 0.054 13.8 0.1 11.9 11 3 3 14 14 14 0 Csm1 N-terminal domain Inhibitor_I9 PF05922.16 EFO64426.1 - 2 9.2 4.6 4.5 8.0 0.4 3.7 3 0 0 3 3 3 0 Peptidase inhibitor I9 CBFD_NFYB_HMF PF00808.23 EFO64429.1 - 4.4e-10 39.7 0.0 5.7e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFO64429.1 - 2.5e-06 27.9 0.2 3.5e-06 27.4 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 MlaE PF02405.16 EFO64429.1 - 0.023 14.4 0.1 0.028 14.1 0.1 1.1 1 0 0 1 1 1 0 Permease MlaE WD40 PF00400.32 EFO64430.1 - 4.9e-13 49.3 1.9 0.0048 17.7 0.2 5.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO64430.1 - 2.9e-08 33.9 0.0 0.00011 22.4 0.0 4.0 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFO64430.1 - 0.00061 18.8 0.0 0.4 9.6 0.0 2.3 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein EF-1_beta_acid PF10587.9 EFO64430.1 - 5.9 7.4 10.4 0.89 10.1 1.9 2.4 2 0 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region ATP_transf PF09830.9 EFO64432.1 - 3.6e-05 23.8 0.0 8.4e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 ATP adenylyltransferase Annexin PF00191.20 EFO64433.1 - 3e-08 33.6 0.0 0.0014 18.7 0.0 3.6 3 1 0 3 3 3 3 Annexin Annexin PF00191.20 EFO64434.1 - 3.4e-11 43.0 1.1 0.0033 17.5 0.0 4.2 4 0 0 4 4 4 2 Annexin TipAS PF07739.13 EFO64434.1 - 0.001 19.6 0.8 0.013 16.0 0.1 2.7 3 0 0 3 3 3 1 TipAS antibiotic-recognition domain UreF PF01730.16 EFO64434.1 - 0.066 13.8 0.8 4.4 7.9 0.1 2.3 2 0 0 2 2 2 0 UreF RuvA_C PF07499.13 EFO64434.1 - 0.076 13.5 2.3 0.17 12.3 0.3 2.7 3 0 0 3 3 3 0 RuvA, C-terminal domain GUN4_N PF16416.5 EFO64434.1 - 0.099 12.6 0.1 0.43 10.6 0.1 1.9 2 0 0 2 2 2 0 ARM-like repeat domain, GUN4-N terminal Annexin PF00191.20 EFO64435.1 - 5.3e-14 52.1 0.5 5.3e-06 26.4 0.0 4.1 4 0 0 4 4 4 3 Annexin Annexin PF00191.20 EFO64436.1 - 6.9e-14 51.7 0.1 7.6e-09 35.5 0.1 3.3 3 0 0 3 3 3 2 Annexin Glyco_transf_29 PF00777.18 EFO64436.1 - 0.048 13.0 0.0 0.072 12.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 29 (sialyltransferase) DUF3888 PF13027.6 EFO64438.1 - 0.23 11.9 1.0 0.98 9.9 1.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3888) SHS2_Rpb7-N PF03876.17 EFO64440.1 - 0.004 17.5 0.0 0.009 16.4 0.0 1.6 1 1 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Fez1 PF06818.15 EFO64441.1 - 0.00067 20.2 48.8 0.055 13.9 9.2 3.8 2 1 1 3 3 3 3 Fez1 DUF3584 PF12128.8 EFO64441.1 - 0.00069 17.3 0.6 0.00069 17.3 0.6 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF3584) UPF0242 PF06785.11 EFO64441.1 - 0.0041 17.2 51.9 0.93 9.6 19.2 4.5 2 1 3 5 5 5 3 Uncharacterised protein family (UPF0242) N-terminus DUF4407 PF14362.6 EFO64441.1 - 0.0061 16.0 41.2 0.18 11.1 0.3 3.6 2 1 1 3 3 3 2 Domain of unknown function (DUF4407) BBP1_C PF15272.6 EFO64441.1 - 0.0062 16.4 8.5 0.0062 16.4 8.5 4.0 2 1 0 3 3 2 1 Spindle pole body component BBP1, C-terminal OmpH PF03938.14 EFO64441.1 - 0.014 15.7 40.8 0.35 11.2 1.3 4.4 2 1 2 4 4 4 0 Outer membrane protein (OmpH-like) BRE1 PF08647.11 EFO64441.1 - 0.016 15.3 4.0 0.016 15.3 4.0 5.9 2 1 3 5 5 4 0 BRE1 E3 ubiquitin ligase ZapB PF06005.12 EFO64441.1 - 0.018 15.4 4.6 0.018 15.4 4.6 6.7 2 1 2 4 4 2 0 Cell division protein ZapB TolA_bind_tri PF16331.5 EFO64441.1 - 0.038 14.1 0.2 0.038 14.1 0.2 6.4 2 1 4 6 6 6 0 TolA binding protein trimerisation CEP63 PF17045.5 EFO64441.1 - 0.066 13.1 47.2 0.38 10.6 1.7 5.2 2 1 1 4 4 4 0 Centrosomal protein of 63 kDa ERM PF00769.19 EFO64441.1 - 0.091 12.6 61.0 0.015 15.1 5.0 4.1 1 1 3 4 4 4 0 Ezrin/radixin/moesin family Spc7 PF08317.11 EFO64441.1 - 0.11 11.3 59.1 0.74 8.6 14.4 4.1 2 1 2 4 4 4 0 Spc7 kinetochore protein Cir_Bir_Yir PF06022.11 EFO64441.1 - 0.13 11.8 8.3 0.2 11.1 0.4 2.6 2 1 0 2 2 2 0 Plasmodium variant antigen protein Cir/Yir/Bir HIP1_clath_bdg PF16515.5 EFO64441.1 - 0.14 12.8 48.2 1.7 9.3 2.9 5.9 2 1 3 5 5 5 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF641 PF04859.12 EFO64441.1 - 0.18 12.1 38.2 0.43 10.9 2.0 5.5 3 1 2 5 5 5 0 Plant protein of unknown function (DUF641) kleA_kleC PF17383.2 EFO64441.1 - 0.25 11.7 0.2 0.25 11.7 0.2 3.7 3 1 2 5 5 5 0 Uncharacterized KorC regulated protein A GAS PF13851.6 EFO64441.1 - 0.49 9.7 58.8 0.099 12.0 2.1 4.9 2 2 3 5 5 5 0 Growth-arrest specific micro-tubule binding HMMR_N PF15905.5 EFO64441.1 - 0.63 9.5 52.6 0.04 13.4 19.9 4.1 2 1 2 4 4 4 0 Hyaluronan mediated motility receptor N-terminal DUF812 PF05667.11 EFO64441.1 - 0.89 8.4 46.7 0.13 11.1 23.0 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF812) Golgin_A5 PF09787.9 EFO64441.1 - 1.2 8.6 50.9 0.49 9.8 13.7 4.2 2 1 2 4 4 4 0 Golgin subfamily A member 5 YojJ PF10372.9 EFO64441.1 - 1.6 8.9 9.6 11 6.2 0.1 4.9 3 1 1 4 4 4 0 Bacterial membrane-spanning protein N-terminus DUF4200 PF13863.6 EFO64441.1 - 1.9 8.9 54.1 0.33 11.4 8.8 5.8 2 1 2 5 5 5 0 Domain of unknown function (DUF4200) NYD-SP28 PF14772.6 EFO64441.1 - 2 8.5 42.6 0.23 11.5 3.4 5.2 2 1 3 5 5 5 0 Sperm tail zf-ZPR1 PF03367.13 EFO64441.1 - 3.1 7.7 16.6 5.7 6.8 1.3 3.6 3 1 1 4 4 4 0 ZPR1 zinc-finger domain CALCOCO1 PF07888.11 EFO64441.1 - 7 5.4 53.9 0.51 9.1 0.6 3.2 2 1 1 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like TMF_TATA_bd PF12325.8 EFO64441.1 - 7.6 6.8 55.4 0.88 9.8 6.9 5.9 2 2 4 6 6 6 0 TATA element modulatory factor 1 TATA binding VSP PF03302.13 EFO64442.1 - 4.9e-74 249.6 154.5 9.1e-72 242.1 93.1 4.0 1 1 3 4 4 4 4 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO64442.1 - 0.00018 21.6 17.2 0.00018 21.6 17.2 10.1 2 2 7 9 9 9 3 Furin-like repeat, cysteine-rich VSP PF03302.13 EFO64443.1 - 8.7e-88 294.8 170.0 4.8e-48 164.0 30.7 4.6 1 1 4 5 5 5 4 Giardia variant-specific surface protein SKG6 PF08693.10 EFO64443.1 - 0.16 11.4 4.6 0.3 10.5 4.6 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Pkinase PF00069.25 EFO64444.1 - 1.5e-26 93.4 0.0 3.2e-26 92.3 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64444.1 - 2e-18 66.6 0.0 3.3e-18 65.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase UPF0242 PF06785.11 EFO64445.1 - 0.52 10.4 24.3 1.8 8.6 2.0 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus FlaC_arch PF05377.11 EFO64445.1 - 0.64 10.5 9.7 4.2 7.8 0.2 3.9 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) TolA_bind_tri PF16331.5 EFO64445.1 - 2.8 8.1 12.0 0.059 13.4 2.7 3.0 2 1 1 3 3 3 0 TolA binding protein trimerisation DUF1664 PF07889.12 EFO64445.1 - 7 6.7 12.0 3 7.9 6.4 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 EFO64445.1 - 7.3 7.1 10.2 2.5 8.6 1.6 3.2 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF2203 PF09969.9 EFO64445.1 - 9.8 6.9 8.7 6.1 7.6 4.3 2.6 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) D123 PF07065.14 EFO64446.1 - 4.2e-15 55.7 1.1 7.4e-15 54.9 0.8 1.4 1 1 1 2 2 2 1 D123 ArsR PF09824.9 EFO64448.1 - 0.097 12.3 0.5 2.8 7.5 0.0 3.0 3 0 0 3 3 3 0 ArsR transcriptional regulator DUF4600 PF15372.6 EFO64448.1 - 0.11 12.9 0.6 0.28 11.6 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) Pre-PUA PF17832.1 EFO64448.1 - 0.13 12.9 0.2 1.1 10.0 0.0 2.6 2 0 0 2 2 2 0 Pre-PUA-like domain Ferritin PF00210.24 EFO64449.1 - 0.011 15.7 0.1 0.022 14.7 0.1 1.5 1 0 0 1 1 1 0 Ferritin-like domain PutA_N PF18083.1 EFO64449.1 - 0.13 12.2 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Proline utilization A N-terminal domain GLTP PF08718.11 EFO64450.1 - 2.7e-19 69.9 0.0 4.8e-17 62.6 0.0 2.1 1 1 0 1 1 1 1 Glycolipid transfer protein (GLTP) DUF4041 PF13250.6 EFO64450.1 - 0.14 12.0 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4041) TSC22 PF01166.18 EFO64451.1 - 0.021 15.1 1.3 0.28 11.5 0.4 3.3 2 0 0 2 2 2 0 TSC-22/dip/bun family PAXX PF15384.6 EFO64452.1 - 0.03 14.0 0.1 0.1 12.3 0.0 1.8 2 1 0 2 2 2 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 Metallophos PF00149.28 EFO64453.1 - 2.7e-08 34.6 0.0 5.2e-08 33.6 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFO64453.1 - 4.1e-08 33.6 0.0 1.7e-07 31.5 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain TatD_DNase PF01026.21 EFO64453.1 - 0.11 11.9 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 TatD related DNase PUF PF00806.19 EFO64456.1 - 1.7e-11 43.1 0.0 0.00071 19.1 0.0 6.0 5 0 0 5 5 5 4 Pumilio-family RNA binding repeat Cnd1 PF12717.7 EFO64457.1 - 1.9e-08 34.6 5.1 5.4e-07 29.8 0.3 4.0 2 2 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFO64457.1 - 0.0053 16.9 5.0 0.22 11.9 0.1 4.6 5 0 0 5 5 5 1 HEAT repeat Gag_p17 PF00540.18 EFO64457.1 - 0.015 15.3 0.1 0.055 13.4 0.1 1.9 1 0 0 1 1 1 0 gag gene protein p17 (matrix protein) Rtt106_N PF18215.1 EFO64457.1 - 0.09 12.5 0.1 0.48 10.2 0.1 2.3 1 0 0 1 1 1 0 Histone chaperone Rtt106 N-terminal domain HEAT_EZ PF13513.6 EFO64457.1 - 0.34 11.5 2.3 3.3 8.3 0.2 3.5 2 1 1 3 3 3 0 HEAT-like repeat RRM_1 PF00076.22 EFO64460.1 - 0.00024 20.9 0.0 0.0011 18.7 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) XK-related PF09815.9 EFO64460.1 - 0.16 11.0 0.0 0.19 10.7 0.0 1.1 1 0 0 1 1 1 0 XK-related protein DUF727 PF05303.12 EFO64461.1 - 5.1e-05 23.3 0.0 0.00021 21.3 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF727) Sybindin PF04099.12 EFO64462.1 - 0.052 13.5 0.1 0.15 12.0 0.1 1.7 1 0 0 1 1 1 0 Sybindin-like family Orai-1 PF07856.12 EFO64462.1 - 0.25 11.0 1.8 16 5.2 0.2 2.6 2 0 0 2 2 2 0 Mediator of CRAC channel activity Phage_holin_2_3 PF16080.5 EFO64463.1 - 1.2 8.9 5.2 1.4 8.8 0.5 2.6 2 0 0 2 2 2 0 Bacteriophage holin family HP1 Pkinase PF00069.25 EFO64464.1 - 8.6e-65 218.7 0.0 1.1e-64 218.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64464.1 - 4.4e-40 137.6 0.0 6.8e-40 137.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFO64464.1 - 2.1e-06 27.0 0.1 3.4e-06 26.3 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EFO64464.1 - 0.0011 18.3 0.0 0.0031 16.9 0.0 1.8 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 EFO64464.1 - 0.0098 15.8 0.4 0.024 14.6 0.4 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFO64464.1 - 0.014 14.7 0.1 0.023 14.0 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFO64464.1 - 0.021 14.4 0.2 0.047 13.3 0.1 1.4 1 1 0 1 1 1 0 RIO1 family TrmO PF01980.16 EFO64466.1 - 2.5e-18 66.4 0.0 9.1e-18 64.6 0.0 1.9 2 0 0 2 2 2 1 tRNA-methyltransferase O V-ATPase_G PF03179.15 EFO64467.1 - 2.7e-12 47.1 13.3 3.3e-12 46.9 13.3 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit V-ATPase_G_2 PF16999.5 EFO64467.1 - 2.1e-07 31.3 15.2 2.4e-07 31.1 15.2 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit ATP-synt_B PF00430.18 EFO64467.1 - 0.0072 16.4 13.6 0.0092 16.1 13.6 1.2 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) HIGH_NTase1 PF05636.11 EFO64467.1 - 0.021 14.1 2.7 0.024 13.9 2.7 1.0 1 0 0 1 1 1 0 HIGH Nucleotidyl Transferase PAD PF03068.15 EFO64467.1 - 0.06 12.3 1.1 0.067 12.2 1.1 1.0 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) RRT14 PF17075.5 EFO64467.1 - 0.15 12.2 8.5 0.16 12.1 8.5 1.1 1 0 0 1 1 1 0 Regular of rDNA transcription protein 14 ZYG-11_interact PF05884.12 EFO64467.1 - 0.53 9.6 2.0 0.57 9.5 2.0 1.0 1 0 0 1 1 1 0 Interactor of ZYG-11 DUF3395 PF11875.8 EFO64467.1 - 1.5 8.7 8.3 1.6 8.6 7.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3395) HSCB_C PF07743.13 EFO64467.1 - 1.6 9.2 11.5 30 5.2 11.5 2.3 1 1 0 1 1 1 0 HSCB C-terminal oligomerisation domain UCH PF00443.29 EFO64468.1 - 3.2e-40 138.3 0.1 4.1e-40 137.9 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFO64468.1 - 4.3e-07 29.8 1.1 8.3e-06 25.6 1.1 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF4408 PF14364.6 EFO64468.1 - 0.16 11.7 0.4 0.33 10.7 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4408) Glycophorin_A PF01102.18 EFO64470.1 - 0.0018 18.5 1.7 1.9 8.8 0.0 3.2 3 0 0 3 3 3 2 Glycophorin A DUF1624 PF07786.12 EFO64470.1 - 0.12 12.0 26.5 0.62 9.6 14.2 3.6 4 1 0 4 4 4 0 Protein of unknown function (DUF1624) Metallophos PF00149.28 EFO64471.1 - 1.1e-22 81.6 0.0 1.7e-22 81.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_1 PF00515.28 EFO64471.1 - 2.4e-15 55.6 3.3 0.00017 21.3 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFO64471.1 - 2e-14 52.5 6.8 0.00042 20.2 0.1 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFO64471.1 - 3.5e-11 43.6 5.0 3.8e-07 30.7 2.5 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFO64471.1 - 1.6e-09 37.2 0.6 0.0034 17.5 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFO64471.1 - 5.6e-08 33.0 2.1 0.1 13.5 0.0 3.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFO64471.1 - 5.1e-07 29.3 0.6 0.051 13.3 0.1 3.3 3 0 0 3 3 3 2 TPR repeat TPR_12 PF13424.6 EFO64471.1 - 3.9e-06 27.1 5.5 0.069 13.5 0.1 4.1 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFO64471.1 - 1.6e-05 24.6 0.7 0.13 12.3 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFO64471.1 - 0.00019 21.8 0.2 0.021 15.3 0.0 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFO64471.1 - 0.00039 20.9 0.6 7.6 7.4 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFO64471.1 - 0.0082 16.5 0.3 21 5.8 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFO64471.1 - 0.01 15.9 0.6 0.036 14.2 0.3 2.1 3 0 0 3 3 2 0 Tetratricopeptide repeat MIT PF04212.18 EFO64471.1 - 0.013 15.5 0.5 0.083 13.0 0.1 2.2 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain DUF5618 PF18498.1 EFO64471.1 - 0.045 14.0 0.0 0.51 10.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5618) TPR_10 PF13374.6 EFO64471.1 - 0.085 12.7 3.9 6.2 6.8 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat HDPD PF02924.14 EFO64472.1 - 0.082 13.0 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage lambda head decoration protein D Ank_2 PF12796.7 EFO64473.1 - 3.1e-65 216.7 10.9 2.4e-15 56.9 0.0 6.6 1 1 4 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64473.1 - 1e-46 156.7 0.6 6.2e-07 29.8 0.0 10.2 7 2 4 11 11 10 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64473.1 - 2.8e-38 125.5 4.0 0.0076 16.7 0.0 12.8 12 1 1 13 13 12 8 Ankyrin repeat Ank_5 PF13857.6 EFO64473.1 - 1.2e-37 127.5 8.8 3.1e-05 24.1 0.0 9.5 3 3 5 9 9 9 8 Ankyrin repeats (many copies) Ank PF00023.30 EFO64473.1 - 3.2e-34 115.9 8.9 0.018 15.5 0.0 12.0 12 1 1 13 13 11 8 Ankyrin repeat Pkinase PF00069.25 EFO64473.1 - 3.4e-32 111.8 0.0 7.7e-32 110.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64473.1 - 3.6e-21 75.6 0.0 5.9e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase IFT57 PF10498.9 EFO64473.1 - 0.0053 15.8 1.1 0.01 14.8 1.1 1.4 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 DUF4200 PF13863.6 EFO64473.1 - 0.011 16.1 2.8 0.011 16.1 2.8 2.0 2 0 0 2 2 1 0 Domain of unknown function (DUF4200) CENP-F_leu_zip PF10473.9 EFO64473.1 - 0.014 15.4 11.7 0.024 14.7 3.2 3.2 3 1 1 4 4 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HMMR_N PF15905.5 EFO64473.1 - 0.023 14.2 4.3 0.043 13.3 4.3 1.4 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF641 PF04859.12 EFO64473.1 - 0.024 15.0 6.7 0.16 12.3 2.0 2.9 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) Spc7 PF08317.11 EFO64473.1 - 0.024 13.5 7.5 0.11 11.4 7.4 2.0 1 1 0 1 1 1 0 Spc7 kinetochore protein AAA_13 PF13166.6 EFO64473.1 - 0.026 13.2 2.3 0.047 12.3 2.3 1.3 1 0 0 1 1 1 0 AAA domain HOOK PF05622.12 EFO64473.1 - 0.031 12.4 3.1 0.054 11.7 3.1 1.3 1 0 0 1 1 1 0 HOOK protein CEP63 PF17045.5 EFO64473.1 - 0.032 14.1 0.4 0.059 13.3 0.4 1.4 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa ATG16 PF08614.11 EFO64473.1 - 0.038 14.2 8.7 0.12 12.6 8.7 1.9 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) ADIP PF11559.8 EFO64473.1 - 0.057 13.5 7.0 0.09 12.9 2.7 2.6 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF3552 PF12072.8 EFO64473.1 - 0.06 12.8 6.6 0.12 11.8 6.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Filament PF00038.21 EFO64473.1 - 0.075 12.6 2.8 0.14 11.7 2.8 1.4 1 0 0 1 1 1 0 Intermediate filament protein DUF4407 PF14362.6 EFO64473.1 - 0.075 12.4 4.1 0.16 11.3 4.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 EFO64473.1 - 0.088 12.9 1.1 0.22 11.6 1.1 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Fib_alpha PF08702.10 EFO64473.1 - 0.093 12.9 0.8 0.26 11.5 0.6 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Nsp1_C PF05064.13 EFO64473.1 - 0.095 12.5 0.6 1.5 8.7 0.1 3.1 4 0 0 4 4 3 0 Nsp1-like C-terminal region DUF16 PF01519.16 EFO64473.1 - 0.13 12.8 0.4 0.33 11.5 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function DUF16 Lzipper-MIP1 PF14389.6 EFO64473.1 - 0.14 12.4 3.0 1.9 8.8 0.2 2.9 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 BLOC1_2 PF10046.9 EFO64473.1 - 0.15 12.4 3.4 0.4 11.0 1.9 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HIP1_clath_bdg PF16515.5 EFO64473.1 - 0.15 12.6 6.2 3.2 8.4 2.5 2.9 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4201 PF13870.6 EFO64473.1 - 0.19 11.5 3.2 0.4 10.4 3.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) HAP1_N PF04849.13 EFO64473.1 - 0.21 10.7 5.5 0.053 12.7 2.0 1.8 2 0 0 2 2 1 0 HAP1 N-terminal conserved region Atg14 PF10186.9 EFO64473.1 - 0.22 10.6 3.1 0.42 9.7 3.1 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 NPV_P10 PF05531.12 EFO64473.1 - 0.32 11.5 3.5 6.6 7.3 0.7 4.0 3 1 0 3 3 2 0 Nucleopolyhedrovirus P10 protein Jnk-SapK_ap_N PF09744.9 EFO64473.1 - 0.59 10.3 5.3 2.4 8.4 5.2 2.0 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 BRE1 PF08647.11 EFO64473.1 - 0.77 9.9 9.3 0.12 12.4 3.9 2.6 2 1 0 2 2 1 0 BRE1 E3 ubiquitin ligase Fez1 PF06818.15 EFO64473.1 - 0.84 10.1 8.4 15 6.0 8.3 2.6 1 1 0 1 1 1 0 Fez1 GAS PF13851.6 EFO64473.1 - 0.95 8.8 5.1 2.5 7.4 3.6 2.1 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding FAM76 PF16046.5 EFO64473.1 - 1 8.6 4.2 3 7.1 4.1 1.8 1 1 0 1 1 1 0 FAM76 protein TRAF_BIRC3_bd PF16673.5 EFO64473.1 - 1.3 8.9 3.9 8.8 6.2 0.1 2.9 2 1 1 3 3 2 0 TNF receptor-associated factor BIRC3 binding domain KxDL PF10241.9 EFO64473.1 - 1.6 9.1 5.5 0.38 11.1 0.4 2.5 3 0 0 3 3 2 0 Uncharacterized conserved protein TMF_DNA_bd PF12329.8 EFO64473.1 - 2.2 8.4 14.5 3 7.9 4.9 4.1 3 1 2 5 5 4 0 TATA element modulatory factor 1 DNA binding Spectrin PF00435.21 EFO64473.1 - 2.4 8.7 5.0 10 6.7 3.4 2.9 2 1 1 3 3 2 0 Spectrin repeat ABC_tran_CTD PF16326.5 EFO64473.1 - 2.5 8.4 10.6 2.8 8.2 1.3 3.4 2 1 1 3 3 2 0 ABC transporter C-terminal domain Striatin PF08232.12 EFO64473.1 - 2.9 8.4 7.1 16 6.1 0.2 2.5 1 1 1 2 2 2 0 Striatin family Prefoldin_2 PF01920.20 EFO64473.1 - 3.3 7.7 6.1 44 4.1 0.4 3.4 1 1 2 3 3 3 0 Prefoldin subunit HrpB7 PF09486.10 EFO64473.1 - 5.6 7.3 10.2 4.2 7.7 5.7 2.6 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Lebercilin PF15619.6 EFO64473.1 - 8 6.1 12.4 1.7 8.2 4.4 3.2 3 1 1 4 4 3 0 Ciliary protein causing Leber congenital amaurosis disease Aa_trans PF01490.18 EFO64474.1 - 2.8e-26 92.2 41.2 5e-14 51.8 19.6 2.2 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein DUF3446 PF11928.8 EFO64474.1 - 0.066 13.5 3.9 0.2 12.0 3.9 1.8 1 0 0 1 1 1 0 Early growth response N-terminal domain Ank_2 PF12796.7 EFO64475.1 - 4.4e-33 113.7 8.0 3.1e-15 56.5 0.3 3.8 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64475.1 - 6.8e-16 58.1 9.6 0.00015 21.9 0.5 5.2 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64475.1 - 1.3e-13 51.1 4.2 0.0028 18.2 0.1 4.4 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO64475.1 - 5.5e-11 42.4 9.2 0.27 11.8 0.1 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EFO64475.1 - 8.4e-08 31.9 7.1 1.8 9.4 0.0 4.7 5 0 0 5 5 5 4 Ankyrin repeat AAA_28 PF13521.6 EFO64476.1 - 2.3e-10 41.0 0.0 3.6e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFO64476.1 - 9.6e-09 35.9 0.0 1.6e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain dNK PF01712.19 EFO64476.1 - 0.0029 17.5 0.1 0.029 14.2 0.1 2.0 1 1 0 1 1 1 1 Deoxynucleoside kinase EcoEI_R_C PF08463.10 EFO64476.1 - 0.0046 17.1 0.0 0.0071 16.5 0.0 1.3 1 0 0 1 1 1 1 EcoEI R protein C-terminal NB-ARC PF00931.22 EFO64476.1 - 0.087 12.0 0.0 1.2 8.3 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain Aminotran_4 PF01063.19 EFO64477.1 - 2.5e-23 83.1 0.0 3.1e-23 82.8 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV LCAT PF02450.15 EFO64478.1 - 1.2e-16 61.0 0.0 2.1e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase PGAP1 PF07819.13 EFO64478.1 - 1.6e-05 24.8 0.2 5.9e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 PGAP1-like protein Hydrolase_4 PF12146.8 EFO64478.1 - 0.00014 21.2 0.0 0.00029 20.2 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Palm_thioest PF02089.15 EFO64478.1 - 0.00016 21.6 0.0 0.0003 20.7 0.0 1.4 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF676 PF05057.14 EFO64478.1 - 0.0026 17.3 0.0 0.0048 16.4 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_2 PF01674.18 EFO64478.1 - 0.0038 16.8 0.0 0.008 15.7 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 2) Abhydrolase_1 PF00561.20 EFO64478.1 - 0.0043 16.7 0.0 0.01 15.5 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Geminin PF07412.12 EFO64478.1 - 0.17 11.6 0.9 0.37 10.5 0.1 2.0 2 0 0 2 2 2 0 Geminin NTP_transf_2 PF01909.23 EFO64479.1 - 2.8e-07 30.7 0.0 6.9e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EFO64479.1 - 0.012 15.7 0.0 0.03 14.4 0.0 1.6 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Pkinase PF00069.25 EFO64480.1 - 1.5e-64 218.0 0.0 2.2e-64 217.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64480.1 - 4.3e-42 144.2 0.0 6.9e-42 143.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO64480.1 - 2e-34 118.0 0.2 2.1e-16 60.3 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64480.1 - 4.1e-15 55.6 0.1 0.0055 17.0 0.0 4.8 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO64480.1 - 1e-14 54.2 0.0 0.072 13.6 0.0 6.1 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 EFO64480.1 - 5.7e-14 52.3 0.1 1.1e-05 25.8 0.0 4.2 2 2 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64480.1 - 3.1e-11 42.5 0.0 0.4 11.4 0.0 5.9 5 0 0 5 5 5 2 Ankyrin repeat Kinase-like PF14531.6 EFO64480.1 - 0.00073 18.9 0.0 0.0017 17.7 0.0 1.7 1 0 0 1 1 1 1 Kinase-like SlyX PF04102.12 EFO64480.1 - 0.01 16.4 0.1 1.7 9.3 0.0 2.6 2 0 0 2 2 2 0 SlyX APH PF01636.23 EFO64480.1 - 0.019 14.9 0.1 0.064 13.2 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family TACC_C PF05010.14 EFO64480.1 - 0.051 13.4 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Pkinase_fungal PF17667.1 EFO64480.1 - 0.13 11.0 0.0 0.21 10.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase DivIC PF04977.15 EFO64480.1 - 0.17 11.7 2.2 8 6.3 0.0 2.9 1 1 1 2 2 2 0 Septum formation initiator Cyclin_N PF00134.23 EFO64481.1 - 4.9e-09 36.0 1.7 6.3e-09 35.7 1.7 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain MIF4G_like PF09088.11 EFO64481.1 - 0.02 14.7 0.3 0.037 13.8 0.3 1.4 1 0 0 1 1 1 0 MIF4G like Cyclin PF08613.11 EFO64481.1 - 0.069 13.5 0.4 0.093 13.1 0.4 1.3 1 0 0 1 1 1 0 Cyclin AAA PF00004.29 EFO64482.1 - 1.4e-37 129.1 0.1 3.5e-37 127.8 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFO64482.1 - 7.2e-07 28.9 0.2 1.8e-06 27.6 0.2 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EFO64482.1 - 1.1e-06 28.9 0.5 0.011 16.1 0.0 3.3 2 1 1 3 3 3 2 AAA domain AAA_16 PF13191.6 EFO64482.1 - 1.1e-06 29.1 0.4 0.001 19.5 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 EFO64482.1 - 1.9e-05 24.9 0.0 9.8e-05 22.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EFO64482.1 - 0.00011 22.3 0.0 0.00034 20.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EFO64482.1 - 0.00084 19.4 0.1 0.0026 17.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EFO64482.1 - 0.0027 17.2 0.1 0.098 12.2 0.0 2.8 3 0 0 3 3 3 1 P-loop containing dynein motor region RNA_helicase PF00910.22 EFO64482.1 - 0.0036 17.7 0.0 0.012 16.0 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.6 EFO64482.1 - 0.0077 16.8 0.0 0.066 13.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFO64482.1 - 0.0088 16.2 0.1 0.061 13.5 0.0 2.3 3 0 0 3 3 2 1 AAA domain Prot_ATP_ID_OB PF16450.5 EFO64482.1 - 0.011 15.7 0.0 0.025 14.5 0.0 1.6 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain IstB_IS21 PF01695.17 EFO64482.1 - 0.016 14.9 0.0 0.037 13.8 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein RuvB_N PF05496.12 EFO64482.1 - 0.024 14.4 0.0 0.15 11.8 0.0 2.3 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 EFO64482.1 - 0.024 14.0 0.1 7.1 5.9 0.0 2.7 2 1 1 3 3 3 0 KaiC DUF815 PF05673.13 EFO64482.1 - 0.027 13.7 0.0 0.049 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) CPT PF07931.12 EFO64482.1 - 0.03 14.2 0.0 0.1 12.5 0.0 1.8 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_25 PF13481.6 EFO64482.1 - 0.056 13.0 0.1 1.4 8.4 0.0 2.3 1 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EFO64482.1 - 0.062 13.0 0.0 0.22 11.2 0.0 2.0 3 0 0 3 3 3 0 Sigma-54 interaction domain ABC_tran PF00005.27 EFO64482.1 - 0.063 13.8 0.0 0.25 11.9 0.0 1.9 1 1 1 2 2 2 0 ABC transporter AAA_24 PF13479.6 EFO64482.1 - 0.11 12.2 0.1 1.8 8.3 0.0 2.6 3 1 0 3 3 3 0 AAA domain DrrA_P4M PF14860.6 EFO64482.1 - 0.21 11.4 1.7 0.44 10.4 1.7 1.5 1 0 0 1 1 1 0 DrrA phosphatidylinositol 4-phosphate binding domain IFRD PF05004.13 EFO64483.1 - 1.3e-12 47.4 0.8 1.9e-12 46.9 0.8 1.2 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) PAS_8 PF13188.7 EFO64483.1 - 0.035 14.1 0.1 0.31 11.1 0.0 2.3 2 0 0 2 2 2 0 PAS domain Peptidase_C1 PF00112.23 EFO64484.1 - 5.7e-31 108.3 3.2 4e-30 105.5 3.2 2.0 1 1 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFO64484.1 - 0.0012 17.7 0.0 1.1 7.9 0.0 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Phage_Mu_Gam PF07352.12 EFO64485.1 - 0.00054 19.9 6.1 0.11 12.4 0.8 2.7 1 1 1 2 2 2 2 Bacteriophage Mu Gam like protein Apolipoprotein PF01442.18 EFO64485.1 - 0.0007 19.5 5.3 0.0034 17.3 5.3 1.9 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain OmpH PF03938.14 EFO64485.1 - 0.002 18.5 4.2 0.02 15.2 3.8 2.3 1 1 1 2 2 2 1 Outer membrane protein (OmpH-like) DUF5082 PF16888.5 EFO64485.1 - 0.0067 16.7 1.1 0.11 12.8 0.1 2.6 1 1 1 2 2 2 1 Domain of unknown function (DUF5082) DUF1664 PF07889.12 EFO64485.1 - 0.013 15.6 0.8 0.013 15.6 0.8 2.4 2 1 1 3 3 2 0 Protein of unknown function (DUF1664) Prominin PF05478.11 EFO64485.1 - 0.02 12.9 7.1 0.068 11.1 1.2 2.0 1 1 1 2 2 2 0 Prominin HR1 PF02185.16 EFO64485.1 - 0.028 14.5 0.1 0.14 12.3 0.1 2.3 1 0 0 1 1 1 0 Hr1 repeat PSII_Pbs27 PF13326.6 EFO64485.1 - 0.046 14.0 0.4 0.42 10.9 0.1 2.2 1 1 0 2 2 2 0 Photosystem II Pbs27 TRAF_BIRC3_bd PF16673.5 EFO64485.1 - 0.073 12.9 0.5 0.34 10.7 0.5 2.2 1 1 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain DASH_Dam1 PF08653.10 EFO64485.1 - 0.078 12.8 2.8 1.2 9.0 0.0 3.4 4 0 0 4 4 4 0 DASH complex subunit Dam1 DUF4407 PF14362.6 EFO64485.1 - 0.12 11.7 3.5 0.22 10.9 3.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) GCN5L1 PF06320.13 EFO64485.1 - 0.15 12.2 2.8 0.3 11.2 0.1 2.4 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) SF-assemblin PF06705.11 EFO64485.1 - 0.28 10.5 14.5 0.058 12.7 7.8 2.2 1 1 0 2 2 2 0 SF-assemblin/beta giardin FUSC PF04632.12 EFO64485.1 - 0.44 9.0 0.9 0.58 8.6 0.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Csm2_III-A PF03750.13 EFO64485.1 - 0.59 11.0 5.5 21 6.0 0.1 2.7 2 1 0 2 2 2 0 Csm2 Type III-A Fzo_mitofusin PF04799.13 EFO64485.1 - 1.1 8.8 5.2 2.3 7.7 0.5 2.5 1 1 1 2 2 2 0 fzo-like conserved region Cor1 PF04803.12 EFO64485.1 - 1.3 9.3 8.8 1.3 9.2 7.1 1.9 1 1 1 2 2 2 0 Cor1/Xlr/Xmr conserved region DUF2203 PF09969.9 EFO64485.1 - 1.3 9.8 6.5 2.4 8.9 0.3 2.7 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Baculo_PEP_C PF04513.12 EFO64485.1 - 1.3 9.0 4.9 0.83 9.7 0.3 2.6 2 2 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Uso1_p115_C PF04871.13 EFO64485.1 - 1.4 9.3 6.2 4.2 7.8 1.7 2.6 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF1640 PF07798.11 EFO64485.1 - 1.7 8.7 10.7 0.64 10.0 3.6 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1640) Exonuc_VII_L PF02601.15 EFO64485.1 - 2 7.9 9.7 1.9 8.0 8.3 1.6 1 1 1 2 2 2 0 Exonuclease VII, large subunit Ank_2 PF12796.7 EFO64486.1 - 1.8e-63 211.1 5.0 1.8e-11 44.5 0.0 6.4 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64486.1 - 1.5e-41 139.9 10.1 1e-07 32.1 0.0 11.5 2 1 10 12 12 12 10 Ankyrin repeats (many copies) Ank PF00023.30 EFO64486.1 - 5.4e-37 124.6 3.1 0.007 16.8 0.0 11.6 9 2 2 11 11 11 9 Ankyrin repeat Ank_3 PF13606.6 EFO64486.1 - 1.1e-31 105.3 2.6 0.044 14.3 0.0 11.4 11 0 0 11 11 11 8 Ankyrin repeat Ank_4 PF13637.6 EFO64486.1 - 5.6e-31 106.5 3.9 3.3e-06 27.5 0.0 8.5 5 3 4 9 9 9 8 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO64486.1 - 4.9e-21 75.3 0.0 7.7e-21 74.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64486.1 - 1.9e-12 47.0 0.0 3.5e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Metallophos_2 PF12850.7 EFO64487.1 - 1e-08 35.5 0.0 6.3e-08 33.0 0.0 2.2 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EFO64487.1 - 5.5e-08 33.6 0.0 1.1e-07 32.5 0.0 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase MatE PF01554.18 EFO64489.1 - 5.3e-28 97.7 38.9 5e-20 71.8 13.9 3.1 3 1 0 3 3 3 2 MatE DUF2909 PF11137.8 EFO64489.1 - 0.18 11.8 3.2 0.15 12.1 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2909) Prominin PF05478.11 EFO64490.1 - 0.00083 17.5 9.8 0.00083 17.5 9.8 1.0 1 0 0 1 1 1 1 Prominin Tweety PF04906.13 EFO64490.1 - 1.3 7.6 9.6 1.4 7.5 9.6 1.1 1 0 0 1 1 1 0 Tweety Ank_2 PF12796.7 EFO64491.1 - 1.5e-43 147.3 4.2 1.6e-13 51.0 0.0 4.8 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO64491.1 - 1.2e-41 142.9 0.0 2e-41 142.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ank PF00023.30 EFO64491.1 - 2.2e-25 87.9 2.2 0.003 17.9 0.0 8.1 7 0 0 7 7 7 6 Ankyrin repeat Ank_3 PF13606.6 EFO64491.1 - 3.6e-25 85.3 1.3 0.045 14.3 0.0 8.8 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 EFO64491.1 - 1.8e-21 75.9 5.3 2.2e-05 24.6 0.0 6.8 3 2 4 7 7 7 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64491.1 - 3e-21 75.5 1.8 6.1e-05 23.5 0.0 6.2 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO64491.1 - 1.8e-19 70.0 0.0 3.2e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO64491.1 - 9.1e-06 25.2 0.0 0.00014 21.3 0.0 2.7 2 1 1 3 3 3 1 Kinase-like Glyco_transf_56 PF07429.11 EFO64491.1 - 0.12 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 4-alpha-L-fucosyltransferase glycosyl transferase group 56 SAM_1 PF00536.30 EFO64491.1 - 0.15 12.5 0.0 0.36 11.3 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Cyclin_N PF00134.23 EFO64492.1 - 0.00038 20.2 0.0 0.00044 20.0 0.0 1.1 1 0 0 1 1 1 1 Cyclin, N-terminal domain HAUS-augmin3 PF14932.6 EFO64493.1 - 0.0012 18.5 0.7 0.0013 18.4 0.7 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 Zwint PF15556.6 EFO64493.1 - 0.0013 18.2 0.5 0.0017 17.9 0.5 1.1 1 0 0 1 1 1 1 ZW10 interactor GOLGA2L5 PF15070.6 EFO64493.1 - 0.0057 15.4 0.9 0.0062 15.3 0.9 1.0 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 KLRAQ PF10205.9 EFO64493.1 - 0.0065 16.7 1.0 0.0093 16.2 1.0 1.4 1 1 0 1 1 1 1 Predicted coiled-coil domain-containing protein YabA PF06156.13 EFO64493.1 - 0.018 15.7 0.2 0.025 15.2 0.2 1.2 1 0 0 1 1 1 0 Initiation control protein YabA CENP-H PF05837.12 EFO64493.1 - 0.032 14.6 1.5 0.044 14.2 1.5 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF4763 PF15960.5 EFO64493.1 - 0.035 13.4 0.4 0.042 13.2 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) CUTL PF16557.5 EFO64493.1 - 0.21 11.8 1.4 0.52 10.5 0.1 2.0 2 0 0 2 2 2 0 CUT1-like DNA-binding domain of SATB GIT_CC PF16559.5 EFO64493.1 - 2.2 8.2 8.1 1.5 8.8 0.9 2.4 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor VSP PF03302.13 EFO64494.1 - 9.1e-57 192.7 78.0 1.4e-33 116.4 23.3 2.0 1 1 1 2 2 2 2 Giardia variant-specific surface protein PRK PF00485.18 EFO64495.1 - 1e-11 45.0 0.0 8.1e-11 42.0 0.0 2.1 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 EFO64495.1 - 0.11 12.7 0.0 0.73 10.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain Pkinase PF00069.25 EFO64496.1 - 1.3e-32 113.2 0.0 1.9e-32 112.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64496.1 - 1.5e-17 63.8 0.0 3.4e-17 62.6 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO64496.1 - 0.0062 15.9 0.0 3.4 6.9 0.0 3.1 3 0 0 3 3 3 2 Kinase-like Pkinase PF00069.25 EFO64497.1 - 1.7e-26 93.2 0.0 4.3e-26 91.8 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64497.1 - 4.2e-14 52.5 0.0 3e-13 49.7 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase SBBP PF06739.11 EFO64497.1 - 1.9 8.6 5.2 3.7 7.6 0.4 2.6 2 0 0 2 2 2 0 Beta-propeller repeat DUF4498 PF14926.6 EFO64499.1 - 0.092 12.1 0.2 4.2 6.6 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4498) COX6C PF02937.15 EFO64502.1 - 0.0022 18.1 0.1 0.064 13.4 0.0 2.5 2 0 0 2 2 2 1 Cytochrome c oxidase subunit VIc DUF2694 PF10904.8 EFO64502.1 - 0.073 13.1 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2694) TPR_9 PF13371.6 EFO64503.1 - 1.8e-10 40.8 0.6 1.4e-06 28.4 0.4 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFO64503.1 - 2.4e-07 30.9 8.6 0.24 11.7 0.1 4.8 3 1 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFO64503.1 - 1.3e-06 27.9 20.4 0.051 13.4 0.1 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFO64503.1 - 4e-06 26.5 17.5 0.99 9.7 0.1 6.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFO64503.1 - 0.00011 22.3 2.0 0.045 14.2 0.0 4.5 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFO64503.1 - 0.00065 19.7 12.8 4.4 7.8 0.1 5.8 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFO64503.1 - 0.0081 15.8 2.5 0.051 13.3 0.0 3.2 3 0 0 3 3 3 1 TPR repeat TPR_19 PF14559.6 EFO64503.1 - 0.016 15.7 5.7 0.044 14.3 0.4 4.1 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFO64503.1 - 0.042 14.7 1.5 4.1 8.5 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_20 PF14561.6 EFO64503.1 - 0.046 14.1 0.2 1 9.7 0.1 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFO64503.1 - 0.05 14.3 2.8 0.13 13.0 0.2 2.8 2 1 1 3 3 2 0 Tetratricopeptide repeat NARP1 PF12569.8 EFO64503.1 - 0.068 12.1 0.0 0.13 11.1 0.0 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TPR_10 PF13374.6 EFO64503.1 - 1.4 8.9 3.6 1.2 9.1 0.1 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFO64503.1 - 8.7 7.2 10.5 60 4.6 0.0 5.7 7 0 0 7 7 5 0 Tetratricopeptide repeat Pkinase PF00069.25 EFO64504.1 - 6.7e-32 110.9 0.1 1.2e-31 110.0 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64504.1 - 3.6e-17 62.5 0.0 7.6e-17 61.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO64504.1 - 0.034 13.4 0.0 0.11 11.8 0.0 1.8 1 1 0 1 1 1 0 Kinase-like NDK PF00334.19 EFO64505.1 - 1.5e-49 167.5 0.0 6.4e-37 126.6 0.0 2.1 2 0 0 2 2 2 2 Nucleoside diphosphate kinase DUF1126 PF06565.12 EFO64505.1 - 0.0005 19.9 0.3 0.00088 19.1 0.3 1.4 1 0 0 1 1 1 1 DUF1126 PH-like domain Ank_2 PF12796.7 EFO64507.1 - 8.2e-70 231.4 21.5 2.2e-13 50.6 0.1 6.8 2 2 6 8 8 8 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64507.1 - 9.5e-40 134.2 8.0 6.5e-05 23.1 0.0 11.5 3 3 9 12 12 12 12 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64507.1 - 1.6e-32 107.9 7.3 0.067 13.8 0.0 12.5 13 0 0 13 13 13 10 Ankyrin repeat Ank PF00023.30 EFO64507.1 - 4.1e-32 109.2 9.7 0.054 14.0 0.0 12.1 11 1 1 12 12 12 9 Ankyrin repeat Ank_4 PF13637.6 EFO64507.1 - 2e-28 98.4 6.5 3.1e-05 24.4 0.0 9.1 4 4 7 11 11 11 9 Ankyrin repeats (many copies) PP2C PF00481.21 EFO64508.1 - 5e-32 111.5 0.0 2e-31 109.6 0.0 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C Aconitase_B_N PF11791.8 EFO64509.1 - 0.034 14.2 0.1 0.044 13.9 0.1 1.1 1 0 0 1 1 1 0 Aconitate B N-terminal domain VSP PF03302.13 EFO64512.1 - 9.3e-91 304.6 102.4 1e-51 176.0 24.8 4.0 1 1 3 4 4 4 4 Giardia variant-specific surface protein Pkinase PF00069.25 EFO64514.1 - 5e-16 58.9 0.3 1.9e-15 56.9 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain YfmQ PF10787.9 EFO64514.1 - 0.00088 19.1 0.4 0.3 10.8 0.3 2.5 2 0 0 2 2 2 2 Uncharacterised protein from bacillus cereus group TPR_MLP1_2 PF07926.12 EFO64514.1 - 1.5 8.9 30.0 3.9 7.5 10.2 3.6 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein HALZ PF02183.18 EFO64514.1 - 1.8 8.9 10.0 1.5 9.1 2.1 3.7 3 0 0 3 3 3 0 Homeobox associated leucine zipper Fez1 PF06818.15 EFO64514.1 - 6.2 7.2 21.6 0.38 11.2 4.0 2.5 1 1 1 2 2 2 0 Fez1 TPR_2 PF07719.17 EFO64515.1 - 0.019 15.0 2.4 1.4 9.2 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat LAGLIDADG_WhiA PF14527.6 EFO64515.1 - 0.6 10.2 4.0 0.48 10.5 0.2 2.9 3 0 0 3 3 3 0 WhiA LAGLIDADG-like domain TPR_6 PF13174.6 EFO64515.1 - 3.9 8.3 6.5 33 5.4 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Flavokinase PF01687.17 EFO64516.1 - 1.2e-27 96.4 0.0 1.6e-27 96.0 0.0 1.0 1 0 0 1 1 1 1 Riboflavin kinase HD PF01966.22 EFO64517.1 - 5.4e-08 33.1 1.9 7.2e-08 32.7 0.5 1.9 2 0 0 2 2 2 1 HD domain PDEase_I PF00233.19 EFO64517.1 - 0.023 14.4 0.7 0.048 13.4 0.7 1.5 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase GAS PF13851.6 EFO64518.1 - 0.00022 20.7 2.8 0.00022 20.7 2.8 4.2 2 1 2 4 4 4 2 Growth-arrest specific micro-tubule binding OmpH PF03938.14 EFO64518.1 - 0.0035 17.7 48.6 0.0036 17.7 0.2 4.1 3 1 1 4 4 4 2 Outer membrane protein (OmpH-like) Transferrin PF00405.17 EFO64518.1 - 0.064 12.4 0.5 0.11 11.7 0.5 1.3 1 0 0 1 1 1 0 Transferrin Spc7 PF08317.11 EFO64518.1 - 0.16 10.8 47.2 0.14 11.0 1.4 3.3 2 1 0 3 3 3 0 Spc7 kinetochore protein NPV_P10 PF05531.12 EFO64518.1 - 0.56 10.7 6.9 21 5.7 0.2 4.6 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Bacillus_HBL PF05791.11 EFO64518.1 - 3.5 7.4 18.9 1.8 8.4 3.9 3.7 3 1 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Transketolase_N PF00456.21 EFO64519.1 - 2.1e-120 401.7 0.0 3.3e-120 401.1 0.0 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EFO64519.1 - 9.5e-26 90.5 0.7 3.2e-25 88.8 0.2 2.1 3 0 0 3 3 3 1 Transketolase, pyrimidine binding domain DXP_synthase_N PF13292.6 EFO64519.1 - 4.8e-08 32.5 0.0 9.3e-08 31.6 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Transketolase_C PF02780.20 EFO64519.1 - 5.2e-07 29.6 0.0 2.3e-06 27.5 0.0 2.1 1 0 0 1 1 1 1 Transketolase, C-terminal domain TPP_enzyme_C PF02775.21 EFO64519.1 - 2.1e-06 27.6 0.2 5.6e-06 26.2 0.2 1.7 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DUF3015 PF11220.8 EFO64519.1 - 0.043 13.7 0.2 0.45 10.4 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3015) YEATS PF03366.16 EFO64520.1 - 4e-10 39.5 0.6 1.4e-09 37.8 0.1 1.9 2 0 0 2 2 2 1 YEATS family Pentapeptide PF00805.22 EFO64521.1 - 0.061 13.0 0.0 0.22 11.2 0.0 1.9 1 0 0 1 1 1 0 Pentapeptide repeats (8 copies) Ank_2 PF12796.7 EFO64523.1 - 4.2e-09 36.9 0.4 1.2e-05 25.8 0.0 4.2 4 0 0 4 4 4 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64523.1 - 1.4e-05 25.3 1.8 0.0085 16.5 0.0 4.4 3 1 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 EFO64523.1 - 5.9e-05 23.2 0.8 5.6 7.9 0.0 5.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EFO64523.1 - 0.0001 22.7 0.0 1.5 9.5 0.0 4.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO64523.1 - 0.044 14.1 0.0 2.9 8.3 0.0 2.8 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFO64524.1 - 3.6e-55 184.5 20.0 1.3e-13 51.3 0.4 5.8 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64524.1 - 2.4e-35 120.5 7.2 6.2e-07 29.8 0.0 8.7 5 2 4 9 9 9 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO64524.1 - 3.2e-34 116.6 11.8 9.1e-06 25.9 0.1 8.7 2 2 6 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64524.1 - 5.9e-32 106.1 8.8 0.0026 18.1 0.0 11.5 11 0 0 11 11 11 8 Ankyrin repeat Ank PF00023.30 EFO64524.1 - 1.2e-27 95.1 13.8 0.00049 20.4 0.0 11.2 10 2 2 12 12 12 7 Ankyrin repeat Pkinase PF00069.25 EFO64524.1 - 3.3e-25 88.9 0.0 1.2e-24 87.1 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64524.1 - 6.1e-16 58.5 0.0 1.5e-15 57.2 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO64525.1 - 2.7e-44 149.6 6.4 2e-13 50.7 0.0 3.5 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64525.1 - 8.3e-22 77.0 6.8 1.6e-05 25.1 0.0 6.1 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64525.1 - 7.8e-17 61.4 3.8 0.00094 19.7 0.1 5.2 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64525.1 - 6e-16 56.9 2.8 0.0023 18.3 0.0 6.0 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 EFO64525.1 - 2e-15 56.4 3.5 0.0031 17.9 0.0 5.9 4 2 1 5 5 5 3 Ankyrin repeat Ank_2 PF12796.7 EFO64526.1 - 5.4e-42 142.3 13.7 2e-11 44.3 0.1 6.7 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64526.1 - 2.1e-29 101.2 4.3 3.4e-05 24.0 0.0 8.2 6 2 2 8 8 8 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO64526.1 - 1.4e-19 69.6 13.8 0.16 12.5 0.0 10.6 10 1 1 11 11 11 7 Ankyrin repeat Ank_3 PF13606.6 EFO64526.1 - 5.6e-19 66.3 14.7 0.099 13.3 0.0 11.4 12 0 0 12 12 12 4 Ankyrin repeat Pkinase PF00069.25 EFO64526.1 - 1.9e-18 66.8 0.0 8.2e-18 64.7 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 EFO64526.1 - 3.1e-14 53.1 7.5 0.013 16.1 0.0 6.4 5 2 1 6 6 6 5 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO64526.1 - 4.4e-10 39.3 0.0 7.9e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO64526.1 - 0.058 12.7 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Kinase-like EGF_2 PF07974.13 EFO64527.1 - 4.6e-05 23.7 358.7 0.001 19.4 6.1 29.7 28 1 0 28 28 28 19 EGF-like domain Plasmod_Pvs28 PF06247.11 EFO64527.1 - 0.00035 20.8 4.3 0.00035 20.8 4.3 24.5 24 3 3 27 27 27 4 Pvs28 EGF domain hEGF PF12661.7 EFO64527.1 - 0.0047 17.5 7.3 0.0047 17.5 7.3 30.5 31 1 0 31 31 31 9 Human growth factor-like EGF EGF PF00008.27 EFO64527.1 - 0.0071 16.6 4.0 0.0071 16.6 4.0 30.6 29 1 1 30 30 30 15 EGF-like domain Ank_2 PF12796.7 EFO64531.1 - 2.6e-67 223.4 10.0 9.7e-12 45.3 0.0 7.3 2 2 7 9 9 9 9 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64531.1 - 2.9e-41 139.0 14.3 2.2e-07 31.0 0.3 8.6 4 2 5 9 9 9 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64531.1 - 9.5e-35 118.5 9.6 1.2e-07 32.1 0.0 9.6 6 3 3 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64531.1 - 5.9e-32 106.1 4.2 0.0059 17.0 0.0 10.8 11 0 0 11 11 10 6 Ankyrin repeat Ank PF00023.30 EFO64531.1 - 6.7e-31 105.4 5.9 0.01 16.3 0.0 11.0 12 0 0 12 12 10 6 Ankyrin repeat Spc7 PF08317.11 EFO64531.1 - 0.0018 17.3 5.2 0.0018 17.3 5.2 2.3 3 0 0 3 3 3 1 Spc7 kinetochore protein UBD PF16455.5 EFO64531.1 - 0.1 12.8 0.1 4.9 7.4 0.0 3.3 3 0 0 3 3 3 0 Ubiquitin-binding domain NBP1 PF08537.10 EFO64531.1 - 0.12 11.8 2.0 0.24 10.8 2.0 1.5 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 Filament PF00038.21 EFO64531.1 - 0.32 10.5 13.7 0.014 15.0 6.6 2.2 2 1 0 2 2 2 0 Intermediate filament protein TolA_bind_tri PF16331.5 EFO64531.1 - 0.38 10.9 11.9 0.046 13.8 2.7 3.4 3 0 0 3 3 2 0 TolA binding protein trimerisation Cnn_1N PF07989.11 EFO64531.1 - 0.43 10.8 3.7 9.4 6.5 0.1 3.0 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 V_ATPase_I PF01496.19 EFO64531.1 - 0.87 7.4 7.3 0.056 11.4 2.1 1.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family PKcGMP_CC PF16808.5 EFO64531.1 - 1.4 8.9 6.3 0.64 9.9 0.9 3.0 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase YabA PF06156.13 EFO64531.1 - 1.6 9.4 5.1 1.5 9.5 0.9 2.9 2 0 0 2 2 2 0 Initiation control protein YabA FapA PF03961.13 EFO64531.1 - 4.5 5.8 9.9 9.2 4.7 9.9 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A Ank_2 PF12796.7 EFO64532.1 - 6.1e-46 154.9 23.8 2.1e-10 41.0 1.6 6.9 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64532.1 - 3.8e-27 94.0 21.1 1.5e-05 25.2 0.0 9.5 5 4 5 10 10 10 8 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64532.1 - 9.5e-25 86.7 14.9 1.6e-05 25.4 0.1 9.4 8 1 1 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64532.1 - 6.2e-19 66.1 21.5 0.017 15.6 0.0 11.5 12 0 0 12 12 12 5 Ankyrin repeat Ank PF00023.30 EFO64532.1 - 2.7e-18 65.5 25.6 0.0066 16.9 0.0 12.4 11 2 1 12 12 12 4 Ankyrin repeat DUF4709 PF15821.5 EFO64532.1 - 0.06 13.6 0.3 0.06 13.6 0.3 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4709) FapA PF03961.13 EFO64532.1 - 7 5.1 10.9 0.55 8.8 0.1 2.9 3 0 0 3 3 3 0 Flagellar Assembly Protein A ZapB PF06005.12 EFO64532.1 - 8.8 6.8 33.9 4.4 7.8 8.8 5.5 5 0 0 5 5 5 0 Cell division protein ZapB Ank_2 PF12796.7 EFO64533.1 - 1.9e-96 316.8 37.2 2.3e-10 40.9 0.3 13.4 4 3 9 13 13 13 13 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64533.1 - 1.4e-50 168.6 44.1 1.2e-07 31.8 0.0 16.5 11 4 6 17 17 17 14 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO64533.1 - 6.9e-48 163.3 0.0 2.5e-47 161.5 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Ank PF00023.30 EFO64533.1 - 4.7e-45 150.1 42.6 0.0011 19.3 0.0 22.2 22 2 2 24 24 23 9 Ankyrin repeat Ank_3 PF13606.6 EFO64533.1 - 2e-42 138.3 45.6 0.043 14.4 0.1 23.3 25 0 0 25 25 24 10 Ankyrin repeat Ank_4 PF13637.6 EFO64533.1 - 1.1e-40 137.5 38.0 4.7e-05 23.9 0.0 16.9 12 4 5 17 17 17 12 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO64533.1 - 1.3e-30 106.6 0.0 2.6e-30 105.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO64533.1 - 2.5e-06 27.0 0.0 6.1e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFO64533.1 - 0.0017 17.2 0.0 0.003 16.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFO64533.1 - 0.0029 17.5 0.0 0.0063 16.5 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF3447 PF11929.8 EFO64533.1 - 0.057 13.4 0.0 0.71 9.9 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3447) Ank_2 PF12796.7 EFO64534.1 - 2.4e-34 117.8 3.9 2.2e-12 47.4 0.1 4.8 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO64534.1 - 1.5e-18 64.9 1.3 0.09 13.4 0.0 7.6 7 0 0 7 7 7 5 Ankyrin repeat Ank_4 PF13637.6 EFO64534.1 - 1.7e-13 50.7 3.1 0.017 15.7 0.1 6.3 5 1 1 6 6 6 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO64534.1 - 2.2e-13 50.0 0.4 0.36 11.4 0.1 7.2 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 EFO64534.1 - 2.4e-11 43.6 2.5 0.04 14.3 0.3 5.0 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Phage_HK97_TLTM PF06120.11 EFO64534.1 - 0.00066 19.0 3.4 0.00066 19.0 3.4 3.1 3 1 0 3 3 3 1 Tail length tape measure protein Cep57_CLD_2 PF14197.6 EFO64534.1 - 0.011 15.8 2.8 0.011 15.8 2.8 4.9 6 0 0 6 6 6 0 Centrosome localisation domain of PPC89 VASP_tetra PF08776.11 EFO64534.1 - 0.019 14.6 0.8 0.019 14.6 0.8 2.7 2 0 0 2 2 2 0 VASP tetramerisation domain DUF4407 PF14362.6 EFO64534.1 - 0.026 13.9 10.3 1.3 8.3 0.5 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4407) DUF4164 PF13747.6 EFO64534.1 - 0.29 11.4 16.9 1.1 9.6 1.4 4.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4164) Fez1 PF06818.15 EFO64534.1 - 1 9.8 19.4 0.23 11.9 0.4 4.0 2 1 1 4 4 4 0 Fez1 YabA PF06156.13 EFO64534.1 - 1.1 10.0 16.9 0.57 10.8 0.8 5.0 4 1 0 4 4 4 0 Initiation control protein YabA Cnn_1N PF07989.11 EFO64534.1 - 1.7 8.8 19.7 5.6 7.2 0.2 5.8 5 0 0 5 5 5 0 Centrosomin N-terminal motif 1 ING PF12998.7 EFO64534.1 - 3 8.5 17.0 4.7 7.9 0.3 4.6 4 1 0 4 4 4 0 Inhibitor of growth proteins N-terminal histone-binding TMF_TATA_bd PF12325.8 EFO64534.1 - 4.7 7.5 27.8 11 6.3 0.9 5.8 5 0 0 5 5 5 0 TATA element modulatory factor 1 TATA binding PE PF00934.20 EFO64534.1 - 5 7.5 7.4 22 5.5 0.5 3.1 3 0 0 3 3 2 0 PE family Ank_2 PF12796.7 EFO64535.1 - 5.8e-49 164.6 14.8 4.4e-11 43.2 0.0 6.5 3 3 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64535.1 - 6.9e-29 99.5 21.8 3.9e-06 27.0 0.1 9.1 3 3 6 9 9 9 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64535.1 - 1.9e-27 95.2 12.2 0.00019 21.9 0.1 8.3 7 1 1 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64535.1 - 4.6e-20 69.6 18.7 0.1 13.2 0.1 10.8 11 0 0 11 11 11 6 Ankyrin repeat Ank PF00023.30 EFO64535.1 - 4.7e-19 67.9 14.7 0.016 15.7 0.0 9.5 9 0 0 9 9 9 6 Ankyrin repeat Lzipper-MIP1 PF14389.6 EFO64535.1 - 1.3 9.3 14.3 3.5 8.0 2.3 4.6 4 0 0 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 Tyr_Deacylase PF02580.16 EFO64536.1 - 1.1e-45 155.7 0.0 1.2e-45 155.5 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase VSP PF03302.13 EFO64538.1 - 5.8e-77 259.2 145.6 2.8e-72 243.8 91.7 4.8 1 1 4 5 5 5 4 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO64538.1 - 6.8e-06 26.2 36.1 2.9e-05 24.2 16.1 9.8 1 1 6 9 9 9 4 Furin-like repeat, cysteine-rich DUF4215 PF13948.6 EFO64538.1 - 0.026 14.9 8.9 0.026 14.9 8.9 10.7 9 4 1 10 10 10 0 Domain of unknown function (DUF4215) Filament PF00038.21 EFO64539.1 - 0.002 17.8 19.8 0.002 17.8 19.8 10.0 4 3 5 10 10 10 3 Intermediate filament protein DUF3800 PF12686.7 EFO64539.1 - 0.014 16.0 0.0 3.2e+02 2.0 0.0 5.9 4 3 0 4 4 4 0 Protein of unknown function (DUF3800) Peptidase_M3_N PF08439.10 EFO64539.1 - 4.3 7.7 12.3 0.19 12.1 2.0 3.8 3 0 0 3 3 3 0 Oligopeptidase F Fe-ADH PF00465.19 EFO64540.1 - 2.4e-70 237.2 0.0 2.7e-70 237.0 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EFO64540.1 - 1.1e-06 28.5 0.0 3.1e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 Iron-containing alcohol dehydrogenase Pkinase PF00069.25 EFO64541.1 - 1.6e-77 260.5 0.2 2.9e-77 259.6 0.1 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64541.1 - 7e-43 146.8 0.0 1.1e-42 146.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO64541.1 - 2.9e-09 36.7 0.0 9.9e-09 34.9 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EFO64541.1 - 9.1e-07 28.1 0.3 1.4e-06 27.5 0.3 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFO64541.1 - 2.4e-06 27.1 0.8 1.2e-05 24.8 0.3 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFO64541.1 - 0.0001 22.0 0.5 0.00018 21.2 0.5 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EFO64541.1 - 0.0081 16.1 0.2 0.094 12.6 0.0 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFO64541.1 - 0.058 13.0 3.7 0.11 12.0 0.7 2.6 2 1 1 3 3 3 0 Choline/ethanolamine kinase TACC_C PF05010.14 EFO64542.1 - 5.8 6.6 8.1 0.41 10.4 2.4 1.9 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Snf7 PF03357.21 EFO64543.1 - 3.7e-07 29.9 2.1 5.4e-07 29.4 2.1 1.3 1 1 0 1 1 1 1 Snf7 CEP63 PF17045.5 EFO64543.1 - 0.0037 17.2 2.3 0.0047 16.9 2.3 1.1 1 0 0 1 1 1 1 Centrosomal protein of 63 kDa Aminotran_4 PF01063.19 EFO64543.1 - 0.0095 15.8 0.2 0.015 15.2 0.2 1.5 1 1 0 1 1 1 1 Amino-transferase class IV BAR_3 PF16746.5 EFO64543.1 - 0.017 14.8 2.1 0.67 9.6 0.3 2.4 1 1 1 2 2 2 0 BAR domain of APPL family BLOC1_2 PF10046.9 EFO64543.1 - 0.049 13.9 2.3 2.7 8.3 0.5 2.7 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4478 PF14793.6 EFO64543.1 - 0.055 13.3 0.4 0.14 12.1 0.4 1.6 1 1 0 1 1 1 0 Pyrimidine/purine nucleotide 5'-monophosphate nucleosidases SKA1 PF07160.12 EFO64543.1 - 0.085 12.7 4.1 0.12 12.2 4.0 1.4 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF2730 PF10805.8 EFO64543.1 - 0.12 12.5 0.9 6.4 6.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) SlyX PF04102.12 EFO64543.1 - 0.15 12.7 3.3 1.1 10.0 0.2 3.1 3 2 0 3 3 3 0 SlyX ING PF12998.7 EFO64543.1 - 0.5 11.0 5.9 6.3 7.4 4.2 2.8 2 1 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding PhoU PF01895.19 EFO64543.1 - 0.9 10.0 6.9 8 7.0 3.8 2.7 2 1 0 2 2 2 0 PhoU domain HR1 PF02185.16 EFO64543.1 - 1.3 9.2 8.7 5.6 7.2 2.4 2.7 3 0 0 3 3 3 0 Hr1 repeat DNTTIP1_dimer PF18192.1 EFO64543.1 - 1.5 9.2 8.2 1.2 9.5 2.2 3.1 2 2 0 2 2 2 0 DNTTIP1 dimerisation domain DEAD PF00270.29 EFO64544.1 - 1.7e-40 138.6 0.0 3.4e-40 137.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO64544.1 - 1.7e-24 86.3 0.0 5e-24 84.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFO64544.1 - 7.7e-06 26.0 0.0 1.5e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EFO64544.1 - 0.001 19.4 0.0 1.1 9.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain CTP_transf_1 PF01148.20 EFO64545.1 - 2.6e-43 148.7 21.0 1.5e-42 146.2 21.0 1.9 1 1 0 1 1 1 1 Cytidylyltransferase family ING PF12998.7 EFO64547.1 - 0.037 14.6 1.5 0.037 14.6 1.5 4.6 3 2 2 5 5 5 0 Inhibitor of growth proteins N-terminal histone-binding TSC22 PF01166.18 EFO64547.1 - 0.4 11.0 18.9 3.1 8.2 0.7 6.6 6 1 1 7 7 7 0 TSC-22/dip/bun family CC2-LZ PF16516.5 EFO64547.1 - 0.52 10.7 23.0 0.067 13.6 1.0 5.5 4 1 1 5 5 5 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Pox_A_type_inc PF04508.12 EFO64547.1 - 0.56 10.2 4.2 1.1 9.2 0.4 3.3 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat T3SchapCesA PF11439.8 EFO64547.1 - 0.58 10.3 11.6 5 7.3 2.2 3.1 2 1 1 3 3 3 0 Type III secretion system filament chaperone CesA ZapB PF06005.12 EFO64547.1 - 0.8 10.2 33.5 0.065 13.7 1.5 6.0 4 3 1 5 5 5 0 Cell division protein ZapB Rnk_N PF14760.6 EFO64547.1 - 2 9.0 4.9 2 8.9 0.8 3.1 3 0 0 3 3 3 0 Rnk N-terminus CPSase_L_D3 PF02787.19 EFO64547.1 - 2.1 8.7 5.5 13 6.1 0.8 3.5 2 1 0 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Occludin_ELL PF07303.13 EFO64547.1 - 6.1 7.6 17.1 0.5 11.1 0.8 4.9 4 2 2 6 6 6 0 Occludin homology domain Ank_2 PF12796.7 EFO64548.1 - 5.4e-73 241.6 27.3 3.3e-14 53.2 0.3 8.3 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64548.1 - 7.5e-48 160.3 14.9 3.4e-06 27.5 0.1 11.1 7 3 2 11 11 11 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO64548.1 - 2.6e-46 155.0 22.4 6.4e-06 26.4 0.0 12.6 3 2 8 12 12 12 11 Ankyrin repeats (many copies) Ank PF00023.30 EFO64548.1 - 1.7e-42 142.0 28.3 0.0023 18.3 0.8 14.8 14 1 1 15 15 15 11 Ankyrin repeat Ank_3 PF13606.6 EFO64548.1 - 1.8e-35 116.9 17.8 0.069 13.7 0.0 15.2 15 0 0 15 15 15 8 Ankyrin repeat Pkinase PF00069.25 EFO64548.1 - 2.2e-22 79.7 0.0 1.9e-21 76.6 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64548.1 - 1.7e-13 50.4 0.0 3.3e-06 26.6 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFO64548.1 - 0.083 12.2 0.0 0.23 10.7 0.0 1.7 2 0 0 2 2 2 0 Kinase-like Histone PF00125.24 EFO64550.1 - 4.6e-12 46.4 0.4 5.9e-12 46.1 0.1 1.3 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFO64550.1 - 2.1e-10 40.7 0.0 3.2e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone_H2A_C PF16211.5 EFO64550.1 - 0.069 12.9 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 C-terminus of histone H2A TFIID-18kDa PF02269.16 EFO64550.1 - 0.12 12.4 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit DUF1347 PF07079.11 EFO64551.1 - 0.0024 16.6 0.3 0.0027 16.3 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1347) LRR_9 PF14580.6 EFO64551.1 - 0.027 14.0 1.1 0.042 13.4 1.1 1.2 1 0 0 1 1 1 0 Leucine-rich repeat DUF717 PF05338.12 EFO64551.1 - 0.21 11.7 0.8 0.76 9.9 0.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF717) KAP PF05804.12 EFO64552.1 - 5.6e-36 124.0 10.2 3.2e-33 114.9 5.9 2.3 2 0 0 2 2 2 2 Kinesin-associated protein (KAP) RloB PF13707.6 EFO64552.1 - 0.026 14.7 1.5 0.043 14.0 1.5 1.3 1 0 0 1 1 1 0 RloB-like protein zf-C3HC4_3 PF13920.6 EFO64553.1 - 1.6e-09 37.5 7.3 1.6e-09 37.5 7.3 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFO64553.1 - 4.4e-07 29.8 4.9 4.6e-07 29.8 1.8 2.7 2 1 1 3 3 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFO64553.1 - 2.3e-06 27.4 8.2 2.3e-06 27.4 8.2 2.2 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EFO64553.1 - 3.8e-06 26.7 6.2 1.2e-05 25.0 6.2 2.0 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EFO64553.1 - 1e-05 25.3 7.9 1e-05 25.3 7.9 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFO64553.1 - 5.3e-05 23.0 12.4 0.00021 21.1 8.0 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 EFO64553.1 - 8.2e-05 22.1 2.0 8.2e-05 22.1 2.0 1.9 2 0 0 2 2 2 1 Rtf2 RING-finger zf-RING_2 PF13639.6 EFO64553.1 - 0.00014 22.1 7.1 0.00014 22.1 7.1 2.5 2 0 0 2 2 2 1 Ring finger domain zf-RING_6 PF14835.6 EFO64553.1 - 0.0015 18.3 1.7 0.004 17.0 1.7 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 EFO64553.1 - 0.0015 18.2 11.7 0.18 11.6 13.0 2.7 1 1 1 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EFO64553.1 - 0.0028 17.8 7.7 0.0028 17.8 7.7 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Fer2_BFD PF04324.15 EFO64553.1 - 0.069 13.5 0.8 2 8.8 0.1 3.0 3 0 0 3 3 2 0 BFD-like [2Fe-2S] binding domain DUF4600 PF15372.6 EFO64553.1 - 0.59 10.6 12.5 3.2 8.2 2.2 3.1 3 1 0 3 3 2 0 Domain of unknown function (DUF4600) zf-P11 PF03854.14 EFO64553.1 - 0.61 9.8 5.0 2.4 7.9 5.0 2.1 1 0 0 1 1 1 0 P-11 zinc finger zinc-ribbons_6 PF07191.12 EFO64553.1 - 0.65 10.0 6.2 12 6.0 1.4 2.5 1 1 1 2 2 2 0 zinc-ribbons zf-Di19 PF05605.12 EFO64553.1 - 5.6 7.3 10.0 0.91 9.9 5.2 2.2 2 1 0 2 2 1 0 Drought induced 19 protein (Di19), zinc-binding zf-CRD PF17979.1 EFO64553.1 - 7.6 6.6 15.3 2 8.5 1.9 3.1 2 1 1 3 3 3 0 Cysteine rich domain with multizinc binding regions zf-CHY PF05495.12 EFO64554.1 - 4.3e-13 49.5 20.7 4.3e-13 49.5 20.7 3.6 2 1 0 2 2 2 1 CHY zinc finger zf-RING_4 PF14570.6 EFO64554.1 - 0.0022 17.8 5.4 0.0022 17.8 5.4 3.8 2 1 0 2 2 2 1 RING/Ubox like zinc-binding domain DUF3788 PF12663.7 EFO64554.1 - 0.079 12.9 0.3 0.16 12.0 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3788) Rap1_C PF11626.8 EFO64554.1 - 0.18 11.9 0.0 0.43 10.7 0.0 1.7 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain zf-C2HC_2 PF13913.6 EFO64554.1 - 5.5 7.0 10.4 8.4 6.4 0.2 4.1 3 0 0 3 3 3 0 zinc-finger of a C2HC-type DUF2569 PF10754.9 EFO64555.1 - 0.017 15.6 0.1 0.058 13.8 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) DUF667 PF05018.13 EFO64557.1 - 7.2e-47 159.5 0.0 1.7e-46 158.3 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF667) Aa_trans PF01490.18 EFO64559.1 - 3.7e-55 187.3 37.2 3.7e-55 187.3 37.2 1.4 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Pox_A14 PF05767.12 EFO64559.1 - 0.38 10.9 0.0 0.38 10.9 0.0 4.5 4 2 1 5 5 5 0 Poxvirus virion envelope protein A14 Aminotran_4 PF01063.19 EFO64560.1 - 0.0045 16.9 0.3 0.0054 16.6 0.3 1.4 1 1 0 1 1 1 1 Amino-transferase class IV BAR_3 PF16746.5 EFO64560.1 - 0.0077 16.0 0.8 0.27 10.9 0.4 2.1 1 1 1 2 2 2 1 BAR domain of APPL family SKA1 PF07160.12 EFO64560.1 - 0.0096 15.8 2.0 0.012 15.5 2.0 1.1 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 DUF4795 PF16043.5 EFO64560.1 - 0.022 14.4 1.2 0.029 14.0 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) BLOC1_2 PF10046.9 EFO64560.1 - 0.026 14.8 2.7 1.3 9.4 0.5 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4478 PF14793.6 EFO64560.1 - 0.029 14.2 0.7 0.043 13.7 0.7 1.4 1 1 0 1 1 1 0 Pyrimidine/purine nucleotide 5'-monophosphate nucleosidases DUF2730 PF10805.8 EFO64560.1 - 0.032 14.3 0.9 2.6 8.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) HlyD_2 PF12700.7 EFO64560.1 - 0.034 12.9 0.6 0.04 12.7 0.6 1.2 1 0 0 1 1 1 0 HlyD family secretion protein DUF3987 PF13148.6 EFO64560.1 - 0.047 12.7 0.1 0.053 12.5 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) SlyX PF04102.12 EFO64560.1 - 0.11 13.2 3.7 0.46 11.1 0.3 2.6 1 1 0 2 2 2 0 SlyX ING PF12998.7 EFO64560.1 - 0.11 13.1 4.5 2.7 8.6 4.5 2.1 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding WXG100 PF06013.12 EFO64560.1 - 0.13 12.5 1.9 0.82 9.9 0.4 2.6 2 1 0 2 2 2 0 Proteins of 100 residues with WXG NPV_P10 PF05531.12 EFO64560.1 - 0.44 11.0 3.2 11 6.5 3.2 2.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein HisKA_3 PF07730.13 EFO64560.1 - 0.7 10.5 4.2 0.41 11.2 0.8 2.1 2 1 0 2 2 2 0 Histidine kinase EGF_2 PF07974.13 EFO64561.1 - 1.9e-08 34.5 351.6 0.019 15.3 0.9 28.8 29 0 0 29 29 29 21 EGF-like domain Plasmod_Pvs28 PF06247.11 EFO64561.1 - 0.00052 20.3 3.5 0.00052 20.3 3.5 25.4 23 3 3 26 26 26 7 Pvs28 EGF domain EGF PF00008.27 EFO64561.1 - 0.004 17.4 7.3 0.004 17.4 7.3 29.9 30 0 0 30 30 30 14 EGF-like domain HemY_N PF07219.13 EFO64561.1 - 8.7 6.6 5.2 10 6.4 4.2 1.5 1 1 1 2 2 2 0 HemY protein N-terminus Ank_2 PF12796.7 EFO64562.1 - 4e-37 126.7 11.2 2.4e-11 44.1 0.5 5.1 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64562.1 - 5.9e-24 83.4 8.3 0.00059 20.2 0.0 9.1 9 0 0 9 9 9 5 Ankyrin repeat Ank_4 PF13637.6 EFO64562.1 - 5.7e-20 71.4 5.2 2.9e-05 24.5 0.0 5.5 4 1 1 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64562.1 - 2.8e-17 61.0 5.4 0.052 14.1 0.0 7.6 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 EFO64562.1 - 3.1e-15 56.0 8.6 0.0018 18.6 0.1 6.4 2 2 4 6 6 6 5 Ankyrin repeats (many copies) ATG16 PF08614.11 EFO64562.1 - 0.0028 17.9 8.9 0.0028 17.9 8.9 3.0 2 1 1 3 3 3 1 Autophagy protein 16 (ATG16) ZapB PF06005.12 EFO64562.1 - 0.039 14.4 0.5 0.039 14.4 0.5 3.4 3 1 0 3 3 3 0 Cell division protein ZapB DUF1154 PF06631.11 EFO64562.1 - 0.18 11.8 1.2 0.54 10.3 1.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1154) SPATA1_C PF15743.5 EFO64562.1 - 0.32 11.0 13.0 0.29 11.2 5.1 2.8 1 1 1 2 2 2 0 Spermatogenesis-associated C-terminus EzrA PF06160.12 EFO64562.1 - 0.36 9.0 12.1 4.5 5.3 12.6 2.0 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA DUF4164 PF13747.6 EFO64562.1 - 0.41 10.9 6.0 0.14 12.4 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) YscO PF07321.12 EFO64562.1 - 0.84 9.6 12.2 0.074 13.0 1.4 2.6 2 0 0 2 2 2 0 Type III secretion protein YscO HMMR_C PF15908.5 EFO64562.1 - 1.2 9.4 7.9 7.7 6.8 0.2 3.4 3 0 0 3 3 3 0 Hyaluronan mediated motility receptor C-terminal GAS PF13851.6 EFO64562.1 - 1.2 8.4 12.3 3.1 7.1 12.3 1.6 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Tropomyosin_1 PF12718.7 EFO64562.1 - 5.7 7.1 14.4 1.6 8.8 1.7 2.5 2 0 0 2 2 2 0 Tropomyosin like DUF4200 PF13863.6 EFO64562.1 - 6 7.3 10.5 20 5.6 2.4 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) DUF641 PF04859.12 EFO64562.1 - 6.4 7.1 12.1 0.62 10.4 0.9 3.1 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) TPR_2 PF07719.17 EFO64564.1 - 0.0049 16.9 0.5 0.49 10.6 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFO64564.1 - 0.079 12.8 0.0 0.72 9.8 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat MCM PF00493.23 EFO64566.1 - 3.3e-81 271.7 0.0 6.4e-81 270.7 0.0 1.5 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFO64566.1 - 6.5e-18 64.8 0.0 2.9e-17 62.7 0.0 2.0 1 1 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFO64566.1 - 8.1e-15 55.0 0.1 2.5e-14 53.5 0.1 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EFO64566.1 - 2.7e-12 46.5 0.0 7.8e-09 35.2 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFO64566.1 - 4.7e-06 26.7 0.0 1.1e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFO64566.1 - 0.00054 19.8 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFO64566.1 - 0.035 13.8 0.0 0.33 10.7 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_30 PF13604.6 EFO64566.1 - 0.041 13.6 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFO64566.1 - 0.072 13.5 2.4 12 6.2 1.0 2.9 1 1 0 2 2 2 0 AAA ATPase domain MCM_N PF14551.6 EFO64566.1 - 0.15 12.6 0.0 0.57 10.8 0.0 2.0 2 0 0 2 2 2 0 MCM N-terminal domain Ank_2 PF12796.7 EFO64567.1 - 6.1e-09 36.4 0.1 3.5e-07 30.7 0.0 3.0 2 1 1 3 3 3 1 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO64567.1 - 2.8e-06 26.9 0.8 6e-06 25.8 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Ank_3 PF13606.6 EFO64567.1 - 0.0032 17.8 0.0 1.9 9.3 0.0 3.9 3 0 0 3 3 3 1 Ankyrin repeat Pkinase_Tyr PF07714.17 EFO64567.1 - 0.033 13.5 0.0 0.16 11.2 0.0 2.1 1 1 0 1 1 1 0 Protein tyrosine kinase Ank_4 PF13637.6 EFO64567.1 - 0.042 14.5 0.0 0.27 11.9 0.0 2.3 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO64567.1 - 0.088 13.1 0.1 1.4 9.3 0.0 2.9 2 1 1 3 3 3 0 Ankyrin repeats (many copies) DNA_binding_2 PF13724.6 EFO64567.1 - 0.26 11.7 0.6 2.8 8.4 0.1 2.4 2 0 0 2 2 2 0 DNA-binding domain APG6_N PF17675.1 EFO64567.1 - 0.6 10.6 12.7 9.4 6.8 6.6 2.9 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF724 PF05266.14 EFO64567.1 - 0.6 9.9 13.0 0.21 11.4 9.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Pkinase PF00069.25 EFO64568.1 - 2.8e-54 184.2 0.0 4.4e-54 183.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EFO64568.1 - 6.1e-43 145.3 14.7 3e-14 53.3 0.2 4.5 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EFO64568.1 - 2.5e-33 115.5 0.0 3.8e-33 114.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank PF00023.30 EFO64568.1 - 2.2e-20 72.1 9.2 0.0011 19.3 0.0 8.0 6 1 1 7 7 7 6 Ankyrin repeat Ank_4 PF13637.6 EFO64568.1 - 3.4e-17 62.6 0.5 4.1e-07 30.4 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO64568.1 - 9.1e-17 60.9 6.9 2e-05 24.8 0.1 7.4 3 2 4 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64568.1 - 2.6e-15 55.0 1.6 0.73 10.6 0.0 7.7 7 0 0 7 7 7 4 Ankyrin repeat Pkinase_fungal PF17667.1 EFO64568.1 - 9.3e-06 24.7 0.0 1.5e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFO64568.1 - 0.023 14.0 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Phage_cap_P2 PF05125.12 EFO64569.1 - 0.11 11.4 0.0 0.65 8.9 0.0 1.9 1 1 0 1 1 1 0 Phage major capsid protein, P2 family Ank_2 PF12796.7 EFO64571.1 - 1.9e-36 124.5 0.1 6.9e-11 42.6 0.0 4.7 3 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64571.1 - 2e-19 69.6 0.8 0.0048 17.5 0.1 6.6 4 1 2 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO64571.1 - 6.1e-19 67.8 0.8 0.01 16.2 0.0 6.4 5 2 2 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64571.1 - 5.6e-17 60.1 0.1 0.085 13.5 0.0 8.6 8 0 0 8 8 8 3 Ankyrin repeat Ank PF00023.30 EFO64571.1 - 5.7e-16 58.2 0.4 0.05 14.1 0.0 7.9 8 0 0 8 8 8 4 Ankyrin repeat Peptidase_C48 PF02902.19 EFO64572.1 - 9.1e-18 64.9 0.9 4.3e-09 36.5 0.5 2.5 2 0 0 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain HpuA PF16960.5 EFO64572.1 - 0.049 12.8 0.4 0.081 12.1 0.4 1.2 1 0 0 1 1 1 0 Haemoglobin-haptoglobin utilisation, porphyrin transporter VSP PF03302.13 EFO64573.1 - 3.9e-16 58.9 59.5 1.2e-12 47.5 17.4 4.0 1 1 1 3 3 3 3 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO64573.1 - 4.6 7.4 35.7 0.025 14.7 14.8 3.7 3 1 0 3 3 3 0 Furin-like repeat, cysteine-rich VSP PF03302.13 EFO64574.1 - 4.6e-12 45.5 108.0 1e-05 24.6 22.1 4.4 1 1 3 4 4 4 4 Giardia variant-specific surface protein Pkinase PF00069.25 EFO64575.1 - 4.1e-21 75.5 0.0 7.3e-21 74.7 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64575.1 - 1.2e-10 41.1 0.0 2.2e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFO64575.1 - 0.00099 19.1 0.0 0.0023 17.9 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Ank_5 PF13857.6 EFO64575.1 - 0.0059 16.9 0.0 0.066 13.6 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) AAA_6 PF12774.7 EFO64576.1 - 6.5e-74 248.8 0.0 3.8e-73 246.3 0.0 2.3 1 1 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFO64576.1 - 1.2e-36 126.8 0.0 1.2e-36 126.8 0.0 4.3 4 1 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 MT PF12777.7 EFO64576.1 - 7.9e-29 100.8 17.6 1.5e-28 99.8 13.9 2.4 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 EFO64576.1 - 1.2e-14 54.4 0.0 4.9e-08 33.1 0.0 3.4 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_9 PF12781.7 EFO64576.1 - 2.9e-07 29.9 0.3 1.6e-06 27.4 0.3 2.3 1 1 0 1 1 1 1 ATP-binding dynein motor region AAA_7 PF12775.7 EFO64576.1 - 3.3e-07 30.0 0.2 0.002 17.7 0.0 4.2 4 0 0 4 4 4 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 EFO64576.1 - 0.00045 20.1 0.0 0.0011 18.8 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 EFO64576.1 - 0.00062 20.0 3.9 1.1 9.6 0.0 4.7 4 0 0 4 4 4 1 AAA domain AAA PF00004.29 EFO64576.1 - 0.059 13.8 0.1 1.2 9.5 0.0 3.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Atg14 PF10186.9 EFO64576.1 - 0.14 11.3 18.2 0.099 11.7 2.8 2.8 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3552 PF12072.8 EFO64576.1 - 0.75 9.2 25.5 3.4 7.0 4.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) DUF87 PF01935.17 EFO64576.1 - 1.3 9.1 6.7 0.3 11.1 0.5 2.9 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_30 PF13604.6 EFO64576.1 - 1.5 8.5 5.8 13 5.4 1.3 3.3 3 0 0 3 3 3 0 AAA domain DUF948 PF06103.11 EFO64576.1 - 1.8 8.9 16.3 0.55 10.5 1.0 4.8 4 0 0 4 4 3 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 EFO64576.1 - 3.8 7.6 19.3 0.28 11.2 1.1 5.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) TolA_bind_tri PF16331.5 EFO64576.1 - 5.8 7.1 20.8 1 9.5 0.1 3.8 3 0 0 3 3 3 0 TolA binding protein trimerisation ABC_tran PF00005.27 EFO64576.1 - 9.3 6.8 6.9 0.9 10.1 0.0 2.9 3 0 0 3 3 2 0 ABC transporter Shugoshin_N PF07558.11 EFO64577.1 - 0.0031 17.3 2.6 0.0055 16.5 2.6 1.4 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region NYD-SP28_assoc PF14775.6 EFO64577.1 - 0.043 13.9 0.7 0.092 12.9 0.7 1.5 1 0 0 1 1 1 0 Sperm tail C-terminal domain AAA_18 PF13238.6 EFO64578.1 - 1.9e-08 35.0 0.1 3e-07 31.0 0.1 2.2 1 1 0 1 1 1 1 AAA domain ADK PF00406.22 EFO64578.1 - 2.3e-06 27.8 0.2 0.0034 17.5 0.0 2.3 1 1 1 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 EFO64578.1 - 0.00012 22.5 0.2 0.013 15.9 0.2 2.3 1 1 0 1 1 1 1 AAA domain Dpy-30 PF05186.13 EFO64578.1 - 0.00045 19.8 0.0 0.00085 19.0 0.0 1.4 1 0 0 1 1 1 1 Dpy-30 motif AAA_28 PF13521.6 EFO64578.1 - 0.0011 19.3 0.0 0.0017 18.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFO64578.1 - 0.0032 17.9 0.0 0.0064 16.9 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain Thymidylate_kin PF02223.17 EFO64578.1 - 0.0035 17.0 0.3 2.3 7.9 0.1 2.2 1 1 1 2 2 2 2 Thymidylate kinase Rad17 PF03215.15 EFO64578.1 - 0.0037 17.2 0.0 0.0059 16.5 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain ABC_tran PF00005.27 EFO64578.1 - 0.0037 17.8 0.0 0.0053 17.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter RIIa PF02197.17 EFO64578.1 - 0.0054 16.4 0.1 0.012 15.3 0.1 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit MMR_HSR1 PF01926.23 EFO64578.1 - 0.019 15.1 0.0 0.028 14.5 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase RuvB_N PF05496.12 EFO64578.1 - 0.021 14.6 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Cytidylate_kin PF02224.18 EFO64578.1 - 0.021 14.6 0.1 0.049 13.4 0.0 1.7 2 0 0 2 2 2 0 Cytidylate kinase KTI12 PF08433.10 EFO64578.1 - 0.024 14.1 0.0 0.047 13.1 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 SRPRB PF09439.10 EFO64578.1 - 0.029 13.8 0.0 0.045 13.2 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PPV_E1_C PF00519.17 EFO64578.1 - 0.031 13.1 0.0 0.04 12.8 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase AAA_33 PF13671.6 EFO64578.1 - 0.037 14.2 0.0 0.077 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EFO64578.1 - 0.048 13.7 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EFO64578.1 - 0.061 13.7 0.0 0.16 12.4 0.0 1.7 2 0 0 2 2 1 0 RNA helicase Mg_chelatase PF01078.21 EFO64578.1 - 0.063 12.7 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_PrkA PF08298.11 EFO64578.1 - 0.063 12.2 0.0 0.73 8.7 0.0 2.1 2 1 0 2 2 2 0 PrkA AAA domain G-alpha PF00503.20 EFO64578.1 - 0.13 11.4 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit DUF2781 PF10914.8 EFO64578.1 - 0.14 12.5 0.0 0.24 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2781) AAA PF00004.29 EFO64578.1 - 0.16 12.4 0.0 0.31 11.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATG16 PF08614.11 EFO64579.1 - 0.0017 18.6 10.9 0.0017 18.6 10.9 18.5 4 3 10 17 17 17 4 Autophagy protein 16 (ATG16) Lebercilin PF15619.6 EFO64579.1 - 0.042 13.5 0.2 0.042 13.5 0.2 17.9 7 5 10 17 17 17 0 Ciliary protein causing Leber congenital amaurosis disease Axin_b-cat_bind PF08833.10 EFO64579.1 - 0.073 13.2 0.0 0.27 11.4 0.0 1.9 1 0 0 1 1 1 0 Axin beta-catenin binding domain Fez1 PF06818.15 EFO64579.1 - 0.14 12.6 202.7 0.046 14.2 11.5 14.2 2 1 8 12 12 12 0 Fez1 Pox_A3L PF05288.11 EFO64579.1 - 0.31 11.1 3.3 1.3 9.0 0.2 4.0 3 0 0 3 3 3 0 Poxvirus A3L Protein Gag_p17 PF00540.18 EFO64579.1 - 0.5 10.3 12.7 3 7.8 0.2 4.7 4 0 0 4 4 4 0 gag gene protein p17 (matrix protein) tRNA-synt_2c PF01411.19 EFO64580.1 - 0.0084 14.7 1.9 0.014 13.9 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class II (A) SMAP PF15477.6 EFO64580.1 - 6.7 7.8 7.1 15 6.6 7.1 1.7 1 1 0 1 1 1 0 Small acidic protein family SUIM_assoc PF16619.5 EFO64580.1 - 9.9 6.3 11.9 6.8 6.8 4.0 2.6 1 1 1 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 AAA_16 PF13191.6 EFO64581.1 - 0.0018 18.6 0.0 0.0032 17.9 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 EFO64581.1 - 0.011 14.9 0.0 0.017 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_28 PF13521.6 EFO64581.1 - 0.06 13.6 0.6 0.23 11.7 0.4 2.0 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.6 EFO64581.1 - 0.32 11.1 1.9 0.52 10.5 0.2 2.2 2 2 1 3 3 3 0 AAA domain TAP42 PF04177.12 EFO64582.1 - 1.1e-16 60.9 10.1 1.1e-16 60.9 10.1 1.9 2 0 0 2 2 2 1 TAP42-like family Motile_Sperm PF00635.26 EFO64583.1 - 0.00028 20.7 0.1 0.00052 19.8 0.1 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Cyclin_N PF00134.23 EFO64584.1 - 1.3e-12 47.5 0.4 2e-12 47.0 0.4 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EFO64584.1 - 1.7e-09 38.3 0.2 2.4e-09 37.7 0.2 1.2 1 0 0 1 1 1 1 Cyclin AMP-binding PF00501.28 EFO64585.1 - 6.5e-86 288.6 0.1 4.7e-61 206.7 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 EFO64585.1 - 0.00022 22.1 0.0 0.00062 20.7 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain tRNA-synt_1b PF00579.25 EFO64586.1 - 3.4e-44 151.3 0.0 4.1e-44 151.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) ABC_tran PF00005.27 EFO64588.1 - 4e-47 160.2 0.0 3.5e-24 85.9 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EFO64588.1 - 4.3e-09 36.6 0.0 0.034 14.0 0.0 3.5 3 0 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFO64588.1 - 8.4e-06 25.4 1.6 0.00013 21.6 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain SMC_N PF02463.19 EFO64588.1 - 0.0011 18.5 0.0 0.54 9.6 0.0 3.1 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 EFO64588.1 - 0.0033 17.2 2.5 1.6 8.4 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_23 PF13476.6 EFO64588.1 - 0.0059 17.1 0.2 0.013 16.0 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EFO64588.1 - 0.039 13.5 0.1 9.4 5.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain MukB PF04310.12 EFO64588.1 - 0.04 13.7 0.1 0.04 13.7 0.1 1.7 2 0 0 2 2 2 0 MukB N-terminal RsgA_GTPase PF03193.16 EFO64588.1 - 0.052 13.4 1.2 2 8.3 0.0 2.7 3 0 0 3 3 3 0 RsgA GTPase FYRN PF05964.14 EFO64588.1 - 0.3 10.9 2.6 0.45 10.4 0.1 2.3 2 0 0 2 2 2 0 F/Y-rich N-terminus RNA_pol_I_A49 PF06870.12 EFO64590.1 - 0.0099 14.8 0.0 0.2 10.5 0.0 2.5 2 1 0 2 2 2 2 A49-like RNA polymerase I associated factor AAA_12 PF13087.6 EFO64591.1 - 1.1e-49 168.8 0.0 1.5e-49 168.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EFO64591.1 - 5e-40 137.9 0.0 7.8e-40 137.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFO64591.1 - 1.6e-14 54.1 0.0 1.5e-12 47.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFO64591.1 - 1.8e-11 44.6 0.0 7.1e-11 42.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 EFO64591.1 - 3.6e-05 23.7 0.0 0.0018 18.2 0.0 2.4 1 1 0 1 1 1 1 Helicase PhoH PF02562.16 EFO64591.1 - 0.00024 20.6 0.0 0.0023 17.4 0.0 2.2 2 0 0 2 2 2 1 PhoH-like protein UvrD-helicase PF00580.21 EFO64591.1 - 0.00092 18.8 0.0 0.15 11.6 0.0 2.3 1 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain ResIII PF04851.15 EFO64591.1 - 0.0075 16.3 0.0 0.018 15.0 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EFO64591.1 - 0.026 14.8 0.1 0.084 13.2 0.1 2.0 1 1 0 1 1 1 0 AAA domain UvrD_C_2 PF13538.6 EFO64591.1 - 0.05 13.4 0.0 0.13 12.1 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain T2SSE PF00437.20 EFO64591.1 - 0.16 11.0 0.0 0.28 10.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein ATP-synt_DE PF00401.20 EFO64591.1 - 1.5 9.1 3.3 4.7 7.6 0.1 2.6 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain SeqA_N PF17206.3 EFO64592.1 - 0.18 11.1 0.8 36 3.8 0.5 3.2 3 0 0 3 3 3 0 SeqA protein N-terminal domain Ank_2 PF12796.7 EFO64593.1 - 2.1e-14 53.9 0.1 1.7e-10 41.3 0.0 1.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64593.1 - 2.6e-06 27.6 0.0 0.024 15.1 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 EFO64593.1 - 2.8e-06 27.2 1.7 0.017 15.6 0.0 3.5 4 0 0 4 4 3 2 Ankyrin repeat Ank_5 PF13857.6 EFO64593.1 - 5.8e-05 23.3 0.0 0.14 12.5 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64593.1 - 0.00021 21.8 0.2 1.1 9.9 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeats (many copies) APG6_N PF17675.1 EFO64593.1 - 0.018 15.5 9.1 0.15 12.6 3.6 3.1 2 2 1 3 3 3 0 Apg6 coiled-coil region HMMR_C PF15908.5 EFO64593.1 - 0.037 14.3 0.5 0.16 12.2 0.3 1.9 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor C-terminal Mto2_bdg PF12808.7 EFO64593.1 - 0.059 13.7 2.8 0.53 10.6 1.2 3.1 3 1 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region GIT_CC PF16559.5 EFO64593.1 - 0.21 11.5 2.7 6.6 6.7 0.3 2.6 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor HALZ PF02183.18 EFO64593.1 - 0.28 11.4 10.6 9.3 6.6 0.2 3.1 2 1 0 2 2 2 0 Homeobox associated leucine zipper ZapB PF06005.12 EFO64593.1 - 0.46 11.0 5.9 0.9 10.0 1.6 2.7 2 1 0 2 2 2 0 Cell division protein ZapB YabA PF06156.13 EFO64593.1 - 0.82 10.3 5.5 9.7 6.9 0.8 2.7 1 1 0 2 2 2 0 Initiation control protein YabA CENP-F_leu_zip PF10473.9 EFO64593.1 - 0.99 9.4 7.0 0.86 9.6 2.1 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cep57_CLD_2 PF14197.6 EFO64593.1 - 1.7 8.8 8.2 7.9 6.7 5.8 3.0 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 MOZART1 PF12554.8 EFO64594.1 - 2.2e-14 52.9 0.3 2.9e-14 52.6 0.3 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated zf-C4H2 PF10146.9 EFO64595.1 - 9.1e-05 22.9 3.5 9.1e-05 22.9 3.5 4.0 2 1 2 4 4 4 1 Zinc finger-containing protein ATG16 PF08614.11 EFO64595.1 - 0.0069 16.6 21.8 0.0069 16.6 21.8 4.5 2 1 2 4 4 4 1 Autophagy protein 16 (ATG16) DUF2046 PF09755.9 EFO64595.1 - 0.044 13.0 36.7 4.5 6.4 33.3 3.6 1 1 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) Golgin_A5 PF09787.9 EFO64595.1 - 0.1 12.0 41.9 0.019 14.5 7.7 3.5 2 1 2 4 4 4 0 Golgin subfamily A member 5 Rab5-bind PF09311.11 EFO64595.1 - 0.14 11.5 32.4 0.17 11.3 13.2 3.2 2 1 1 3 3 3 0 Rabaptin-like protein Spc7 PF08317.11 EFO64595.1 - 0.57 9.0 45.3 0.063 12.1 12.2 3.8 2 1 1 3 3 3 0 Spc7 kinetochore protein YbfN PF13982.6 EFO64595.1 - 1.3 9.3 3.9 10 6.5 0.7 2.5 2 0 0 2 2 2 0 YbfN-like lipoprotein Mei5_like PF17021.5 EFO64595.1 - 3.1 7.9 7.4 15 5.7 0.1 3.1 3 0 0 3 3 3 0 Putative double-strand recombination repair-like FapA PF03961.13 EFO64595.1 - 7.3 5.1 32.2 0.2 10.2 9.6 3.4 2 1 2 4 4 4 0 Flagellar Assembly Protein A Phage_GP20 PF06810.11 EFO64595.1 - 9.2 6.1 39.7 0.28 11.0 7.5 4.9 2 2 3 5 5 5 0 Phage minor structural protein GP20 DUF4989 PF16379.5 EFO64596.1 - 0.028 13.7 0.1 0.033 13.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4989) CCM2_C PF16545.5 EFO64596.1 - 0.11 13.1 0.0 0.13 12.8 0.0 1.2 1 0 0 1 1 1 0 Cerebral cavernous malformation protein, harmonin-homology PseudoU_synth_2 PF00849.22 EFO64597.1 - 4.5e-37 127.6 0.0 7.6e-37 126.9 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase Ank_2 PF12796.7 EFO64598.1 - 1.7e-10 41.3 0.1 0.0003 21.3 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64598.1 - 1e-05 25.7 0.2 0.014 15.7 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO64598.1 - 0.00046 20.5 0.1 8.8 7.0 0.0 4.1 3 1 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 EFO64598.1 - 0.014 15.8 0.1 42 5.2 0.0 4.6 4 0 0 4 4 4 0 Ankyrin repeat PLAC9 PF15205.6 EFO64598.1 - 0.02 15.3 0.3 0.13 12.7 0.0 2.5 2 0 0 2 2 2 0 Placenta-specific protein 9 Ank_4 PF13637.6 EFO64598.1 - 0.033 14.8 0.1 0.73 10.5 0.1 2.9 2 1 1 3 3 3 0 Ankyrin repeats (many copies) TMF_DNA_bd PF12329.8 EFO64598.1 - 0.56 10.2 83.2 0.17 11.9 4.7 11.2 7 5 3 10 10 10 0 TATA element modulatory factor 1 DNA binding PKcGMP_CC PF16808.5 EFO64598.1 - 1.9 8.4 53.1 0.7 9.8 0.1 10.2 10 1 1 11 11 11 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DASH_Dad1 PF08649.10 EFO64598.1 - 4 7.7 11.2 0.17 12.1 1.2 3.4 3 0 0 3 3 3 0 DASH complex subunit Dad1 FAM76 PF16046.5 EFO64600.1 - 0.012 15.0 3.4 0.014 14.8 3.4 1.2 1 0 0 1 1 1 0 FAM76 protein Osmo_CC PF08946.10 EFO64600.1 - 0.037 14.3 0.1 0.037 14.3 0.1 2.0 2 0 0 2 2 2 0 Osmosensory transporter coiled coil Uds1 PF15456.6 EFO64600.1 - 0.078 13.1 7.6 0.24 11.6 5.7 2.0 1 1 1 2 2 2 0 Up-regulated During Septation CENP-R PF06729.12 EFO64600.1 - 0.16 11.9 6.0 0.24 11.3 5.1 1.6 1 1 0 1 1 1 0 Kinetochore component, CENP-R Tropomyosin_1 PF12718.7 EFO64600.1 - 0.28 11.3 8.1 0.53 10.4 7.8 1.6 1 1 1 2 2 2 0 Tropomyosin like DUF776 PF05604.11 EFO64600.1 - 0.48 10.8 6.6 0.78 10.1 6.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF776) TMF_DNA_bd PF12329.8 EFO64600.1 - 0.94 9.5 6.9 1.6 8.8 6.9 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DNA_RNApol_7kD PF03604.13 EFO64601.1 - 0.00064 19.3 2.9 0.0016 18.1 2.9 1.7 1 1 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit Ank_2 PF12796.7 EFO64602.1 - 1.8e-79 262.4 16.5 1.2e-14 54.7 0.3 8.4 3 3 6 9 9 9 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64602.1 - 2.6e-50 168.2 7.8 4.1e-10 40.0 0.0 11.1 10 2 1 11 11 11 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO64602.1 - 3.7e-44 148.2 16.6 0.00026 21.2 0.1 12.2 4 4 7 11 11 11 11 Ankyrin repeats (many copies) Ank PF00023.30 EFO64602.1 - 2.2e-41 138.5 15.5 0.00044 20.6 0.0 14.5 13 2 1 14 14 14 10 Ankyrin repeat Ank_3 PF13606.6 EFO64602.1 - 4.1e-40 131.2 5.7 0.022 15.3 0.0 14.4 15 0 0 15 15 15 8 Ankyrin repeat Pirin PF02678.16 EFO64602.1 - 0.08 12.9 0.2 6.3 6.8 0.1 3.3 3 0 0 3 3 3 0 Pirin TMF_DNA_bd PF12329.8 EFO64602.1 - 0.87 9.6 7.4 2.4 8.2 7.4 1.8 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Csm1_N PF18504.1 EFO64602.1 - 2 8.8 8.8 12 6.4 0.7 2.9 2 1 1 3 3 3 0 Csm1 N-terminal domain Phage_GP20 PF06810.11 EFO64602.1 - 2.1 8.2 9.7 0.093 12.5 2.7 2.4 3 0 0 3 3 3 0 Phage minor structural protein GP20 M16C_assoc PF08367.11 EFO64603.1 - 6.8e-13 48.3 0.0 1.3e-12 47.4 0.0 1.5 1 1 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EFO64603.1 - 7.7e-10 39.1 0.0 1.2e-08 35.1 0.0 2.8 2 2 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFO64603.1 - 4.2e-05 23.6 0.0 8.5e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) zf-ribbon_3 PF13248.6 EFO64605.1 - 0.071 12.5 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 zinc-ribbon domain Dpy-30 PF05186.13 EFO64606.1 - 5.4e-06 26.0 0.0 6.3e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Dpy-30 motif Abhydrolase_6 PF12697.7 EFO64608.1 - 2.4e-16 61.0 0.0 3e-16 60.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFO64608.1 - 3.5e-16 59.2 0.0 4.7e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFO64608.1 - 9e-13 48.4 0.1 1.8e-12 47.5 0.0 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF1057 PF06342.12 EFO64608.1 - 1.1e-08 34.5 0.0 4.6e-08 32.4 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) LIDHydrolase PF10230.9 EFO64608.1 - 1.8e-06 27.7 0.0 2.5e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Thioesterase PF00975.20 EFO64608.1 - 1.3e-05 25.4 0.0 2.4e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain Esterase PF00756.20 EFO64608.1 - 2.7e-05 23.9 0.0 7.8e-05 22.4 0.0 1.8 2 0 0 2 2 2 1 Putative esterase PGAP1 PF07819.13 EFO64608.1 - 0.0085 15.8 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein BAAT_C PF08840.11 EFO64608.1 - 0.01 15.8 0.0 0.019 14.9 0.0 1.6 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Chlorophyllase2 PF12740.7 EFO64608.1 - 0.013 14.4 0.1 0.035 13.0 0.1 1.6 1 1 0 1 1 1 0 Chlorophyllase enzyme DUF676 PF05057.14 EFO64608.1 - 0.026 14.0 0.1 0.047 13.2 0.1 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) UPF0227 PF05728.12 EFO64608.1 - 0.031 14.2 0.0 0.067 13.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Lipase_3 PF01764.25 EFO64608.1 - 0.037 13.9 0.0 0.075 12.9 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_3 PF07859.13 EFO64608.1 - 0.1 12.4 0.1 0.36 10.7 0.1 1.9 1 1 0 1 1 1 0 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 EFO64608.1 - 0.17 11.7 0.0 0.45 10.4 0.0 1.7 2 0 0 2 2 2 0 Serine hydrolase PGBA_C PF15437.6 EFO64609.1 - 0.087 13.2 14.4 0.16 12.4 14.4 1.4 1 0 0 1 1 1 0 Plasminogen-binding protein pgbA C-terminal LMBR1 PF04791.16 EFO64609.1 - 0.55 9.1 5.3 0.73 8.7 5.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Presenilin PF01080.17 EFO64609.1 - 0.61 8.8 3.7 0.83 8.4 3.7 1.1 1 0 0 1 1 1 0 Presenilin Spt5_N PF11942.8 EFO64609.1 - 1.2 10.2 11.7 2.2 9.3 11.7 1.5 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Exonuc_VII_L PF02601.15 EFO64609.1 - 1.8 8.0 6.7 2.4 7.7 6.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4554 PF15091.6 EFO64609.1 - 2 7.2 4.9 2.8 6.7 4.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Abhydrolase_6 PF12697.7 EFO64610.1 - 3e-16 60.7 0.0 4.3e-16 60.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFO64610.1 - 7.8e-10 38.8 0.0 1.8e-09 37.6 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFO64610.1 - 1.7e-09 37.3 0.0 2.6e-06 26.9 0.0 2.3 2 1 0 2 2 2 2 Serine aminopeptidase, S33 Thioesterase PF00975.20 EFO64610.1 - 6.3e-05 23.2 0.0 0.00014 22.0 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain Chlorophyllase2 PF12740.7 EFO64610.1 - 0.00016 20.7 0.0 0.00051 19.0 0.0 1.8 1 1 0 1 1 1 1 Chlorophyllase enzyme LIDHydrolase PF10230.9 EFO64610.1 - 0.00092 18.8 0.0 0.0015 18.1 0.0 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 EFO64610.1 - 0.0016 18.4 0.0 0.0025 17.7 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase UPF0227 PF05728.12 EFO64610.1 - 0.012 15.6 0.0 0.13 12.2 0.0 2.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0227) DUF900 PF05990.12 EFO64610.1 - 0.026 14.1 0.0 0.051 13.1 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Lipase_3 PF01764.25 EFO64610.1 - 0.066 13.1 0.0 0.25 11.2 0.0 1.9 2 0 0 2 2 2 0 Lipase (class 3) SWIRM-assoc_1 PF16495.5 EFO64610.1 - 0.072 13.1 0.3 0.3 11.1 0.1 2.1 2 0 0 2 2 2 0 SWIRM-associated region 1 Bromodomain PF00439.25 EFO64611.1 - 9.7e-07 28.8 0.2 2.3e-06 27.6 0.2 1.6 1 0 0 1 1 1 1 Bromodomain Cortex-I_coil PF09304.10 EFO64611.1 - 0.09 13.0 0.4 0.22 11.8 0.1 1.8 2 0 0 2 2 2 0 Cortexillin I, coiled coil Abhydrolase_1 PF00561.20 EFO64612.1 - 2.3e-14 53.7 0.0 7.2e-14 52.0 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFO64612.1 - 4.9e-12 46.9 0.0 2e-11 44.9 0.0 2.0 2 1 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFO64612.1 - 1.1e-06 28.2 0.0 3e-05 23.4 0.0 2.4 2 0 0 2 2 2 1 Serine aminopeptidase, S33 BAAT_C PF08840.11 EFO64612.1 - 0.00021 21.3 0.0 0.00041 20.3 0.0 1.4 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal LIDHydrolase PF10230.9 EFO64612.1 - 0.0023 17.5 0.0 0.0036 16.9 0.0 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 EFO64612.1 - 0.0043 16.9 0.1 0.066 13.1 0.1 2.4 2 0 0 2 2 2 1 Serine hydrolase Abhydrolase_3 PF07859.13 EFO64612.1 - 0.0058 16.5 0.1 0.028 14.3 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold PGAP1 PF07819.13 EFO64612.1 - 0.013 15.3 0.1 0.023 14.4 0.1 1.3 1 0 0 1 1 1 0 PGAP1-like protein Chlorophyllase2 PF12740.7 EFO64612.1 - 0.018 14.0 0.0 1.9 7.4 0.0 2.2 2 0 0 2 2 2 0 Chlorophyllase enzyme Abhydrolase_8 PF06259.12 EFO64612.1 - 0.026 14.2 0.0 0.051 13.2 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase FSH1 PF03959.13 EFO64612.1 - 0.045 13.4 0.2 5.5 6.6 0.2 3.1 2 1 0 2 2 2 0 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.7 EFO64612.1 - 0.081 12.7 0.0 0.28 11.0 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase family DUF1057 PF06342.12 EFO64612.1 - 0.082 11.9 0.1 0.45 9.5 0.1 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) RMMBL PF07521.12 EFO64613.1 - 3.5e-24 84.5 0.0 7.8e-24 83.4 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Beta-Casp PF10996.8 EFO64613.1 - 1.3e-20 73.7 0.0 5.1e-20 71.8 0.0 2.0 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B_6 PF16661.5 EFO64613.1 - 2.3e-13 50.0 0.0 3.8e-12 46.0 0.0 2.5 1 1 1 2 2 2 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 EFO64613.1 - 5.7e-07 29.7 0.3 3.5e-06 27.2 0.1 2.4 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFO64613.1 - 5.7e-06 26.0 0.1 0.00041 19.9 0.1 2.5 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Ank_2 PF12796.7 EFO64614.1 - 6.8e-23 81.1 3.5 4.5e-10 40.0 0.3 5.4 3 2 2 5 5 5 5 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EFO64614.1 - 9.9e-17 61.1 0.0 2.8e-16 59.6 0.0 1.8 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EFO64614.1 - 3.5e-16 59.3 0.0 8.2e-16 58.1 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Ank_5 PF13857.6 EFO64614.1 - 6e-11 42.4 0.6 3.5e-05 24.0 0.1 5.5 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64614.1 - 4.8e-09 36.6 5.8 1.4e-06 28.7 0.0 5.6 6 2 1 7 7 7 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64614.1 - 2.7e-07 30.4 6.7 15 6.6 0.0 7.6 8 0 0 8 8 8 1 Ankyrin repeat Ank PF00023.30 EFO64614.1 - 2.6e-06 27.6 13.4 1.6 9.3 0.0 7.3 8 2 0 8 8 8 3 Ankyrin repeat Radical_SAM PF04055.21 EFO64615.1 - 1.7e-15 57.8 0.0 1.4e-14 54.8 0.0 2.4 2 1 0 2 2 2 1 Radical SAM superfamily UPF0004 PF00919.20 EFO64615.1 - 8.2e-11 41.8 0.0 7.5e-10 38.7 0.1 2.6 3 1 0 3 3 3 1 Uncharacterized protein family UPF0004 NT5C PF06941.12 EFO64616.1 - 1.7e-13 50.9 0.0 2.6e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Nucleoside_tran PF01733.18 EFO64617.1 - 3.1e-31 108.9 2.6 3.1e-31 108.9 2.6 2.2 1 1 1 2 2 2 1 Nucleoside transporter SEP PF08059.13 EFO64618.1 - 1.8e-08 34.8 0.1 5.5e-08 33.3 0.0 1.9 2 0 0 2 2 2 1 SEP domain zf-ZPR1 PF03367.13 EFO64619.1 - 5.2e-94 312.4 0.3 4.1e-46 156.7 0.4 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain Cript PF10235.9 EFO64619.1 - 0.0088 16.6 2.1 0.25 12.0 0.0 2.4 2 0 0 2 2 2 1 Microtubule-associated protein CRIPT zf-ACC PF17848.1 EFO64619.1 - 0.075 13.1 0.2 0.075 13.1 0.2 3.4 4 0 0 4 4 4 0 Acetyl-coA carboxylase zinc finger domain IMUP PF15761.5 EFO64619.1 - 0.3 11.8 4.2 0.53 11.0 4.2 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein OrfB_Zn_ribbon PF07282.11 EFO64619.1 - 7 6.7 8.2 1.2 9.1 0.4 3.1 3 0 0 3 3 3 0 Putative transposase DNA-binding domain ubiquitin PF00240.23 EFO64620.1 - 8.5e-16 57.5 0.7 9.7e-16 57.3 0.7 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFO64620.1 - 7.2e-06 25.8 0.4 7.5e-06 25.7 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EFO64620.1 - 0.0011 18.8 0.4 0.0013 18.7 0.4 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 EFO64620.1 - 0.011 16.1 0.2 0.016 15.6 0.1 1.4 1 1 0 1 1 1 0 Ubiquitin-like domain Ank_2 PF12796.7 EFO64621.1 - 2.5e-36 124.1 13.2 3.1e-19 69.3 1.3 5.4 3 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64621.1 - 9.9e-22 76.7 8.2 0.00012 22.3 0.1 6.6 4 1 2 6 6 6 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64621.1 - 2.3e-18 66.3 8.6 1.7e-06 28.5 0.1 6.2 6 1 0 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO64621.1 - 6.7e-16 57.9 15.5 0.00084 19.7 0.2 7.8 7 1 1 8 8 8 4 Ankyrin repeat Ank_3 PF13606.6 EFO64621.1 - 1.1e-11 43.8 14.6 0.032 14.8 0.1 8.1 8 0 0 8 8 8 3 Ankyrin repeat Pkinase PF00069.25 EFO64621.1 - 1.4e-07 31.2 0.6 2.1e-05 24.1 0.1 3.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64621.1 - 0.0021 17.4 0.2 0.063 12.6 0.0 2.6 2 1 0 2 2 2 1 Protein tyrosine kinase Thioredoxin_6 PF13848.6 EFO64623.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain RRM_1 PF00076.22 EFO64624.1 - 1.1e-07 31.5 0.3 3.6e-07 29.9 0.1 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFO64624.1 - 0.046 13.3 0.0 0.069 12.8 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Exo_endo_phos PF03372.23 EFO64625.1 - 1.4e-06 28.0 0.0 5.2e-06 26.1 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Cation_ATPase_N PF00690.26 EFO64626.1 - 1.3e-20 72.9 0.0 2e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_efflux PF01545.21 EFO64626.1 - 0.02 14.6 0.5 0.028 14.2 0.5 1.1 1 0 0 1 1 1 0 Cation efflux family UPF0220 PF05255.11 EFO64626.1 - 0.077 12.5 0.7 0.13 11.8 0.7 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0220) PKD_channel PF08016.12 EFO64626.1 - 0.093 11.4 1.4 0.13 10.9 1.4 1.1 1 0 0 1 1 1 0 Polycystin cation channel Ank_2 PF12796.7 EFO64627.1 - 3.3e-44 149.4 12.2 1.9e-14 54.0 0.0 7.9 3 2 4 8 8 8 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64627.1 - 3.1e-25 87.9 16.6 7.7e-06 26.1 0.0 11.0 5 3 6 12 12 12 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO64627.1 - 6.3e-18 64.3 13.7 0.0016 18.8 0.0 10.4 11 0 0 11 11 11 6 Ankyrin repeat Ank_3 PF13606.6 EFO64627.1 - 5.1e-16 57.1 18.8 0.0057 17.1 0.0 12.6 14 0 0 14 14 14 4 Ankyrin repeat Ank_4 PF13637.6 EFO64627.1 - 2.2e-13 50.4 9.3 0.0042 17.6 0.0 7.6 7 2 1 8 8 8 4 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO64627.1 - 0.058 12.7 0.0 0.59 9.4 0.0 2.2 1 1 0 1 1 1 0 Protein kinase domain WD40 PF00400.32 EFO64629.1 - 1.2e-06 29.1 7.2 0.026 15.4 0.0 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat SHIPPO-rpt PF07004.12 EFO64630.1 - 6.3e-08 33.2 20.2 0.095 13.7 0.0 6.8 6 0 0 6 6 6 4 Sperm-tail PG-rich repeat PAS_6 PF08348.11 EFO64630.1 - 0.041 13.7 0.0 0.085 12.7 0.0 1.5 1 0 0 1 1 1 0 YheO-like PAS domain Unpaired PF15972.5 EFO64630.1 - 0.06 12.9 0.1 0.091 12.3 0.1 1.2 1 0 0 1 1 1 0 Unpaired protein ParD PF09386.10 EFO64630.1 - 0.076 13.4 0.0 0.2 12.1 0.0 1.7 1 0 0 1 1 1 0 Antitoxin ParD EF-hand_6 PF13405.6 EFO64631.1 - 5.4e-16 57.1 0.0 2.9e-06 26.7 0.0 3.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 EFO64631.1 - 1.8e-15 57.1 0.0 1.6e-07 31.7 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EFO64631.1 - 1.5e-14 52.3 0.0 9.4e-06 24.8 0.0 3.9 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.6 EFO64631.1 - 4.6e-11 41.7 0.1 6.1e-05 22.3 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EFO64631.1 - 2.1e-08 33.8 0.0 0.016 15.1 0.0 4.1 4 1 1 5 5 5 2 EF-hand domain pair EF-hand_9 PF14658.6 EFO64631.1 - 0.02 15.2 0.0 17 5.8 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain Caleosin PF05042.13 EFO64631.1 - 0.033 14.1 0.0 3.1 7.7 0.0 2.2 1 1 1 2 2 2 0 Caleosin related protein UQ_con PF00179.26 EFO64632.1 - 2.8e-38 130.7 0.0 3.8e-38 130.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFO64632.1 - 0.0037 17.0 0.0 0.0048 16.6 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EFO64632.1 - 0.041 14.2 0.1 0.15 12.3 0.1 1.9 1 1 0 1 1 1 0 RWD domain UEV PF05743.13 EFO64632.1 - 0.1 12.5 0.1 0.15 12.0 0.1 1.2 1 0 0 1 1 1 0 UEV domain WD40 PF00400.32 EFO64633.1 - 1.1e-47 159.0 19.2 3.2e-08 34.1 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO64633.1 - 2e-21 76.1 0.0 6.6e-05 23.1 0.0 5.3 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFO64633.1 - 2.8e-09 36.4 3.2 0.55 9.1 0.1 5.4 1 1 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EFO64633.1 - 5.6e-06 26.1 0.3 3.6 7.6 0.0 5.2 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat eIF2A PF08662.11 EFO64633.1 - 5.7e-06 26.3 0.0 0.0092 15.9 0.0 2.8 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 EFO64633.1 - 0.00032 19.4 0.1 0.062 11.8 0.0 2.6 2 1 1 3 3 3 2 Cytochrome D1 heme domain Nbas_N PF15492.6 EFO64633.1 - 0.0024 17.3 0.4 0.19 11.0 0.1 3.2 1 1 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 EFO64633.1 - 0.032 12.9 4.0 0.1 11.2 1.7 2.5 1 1 2 3 3 3 0 Nucleoporin Nup120/160 DUF1242 PF06842.12 EFO64634.1 - 1.5e-07 31.1 1.4 2.6e-07 30.3 1.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) TMIE PF16038.5 EFO64634.1 - 0.31 10.9 3.7 0.17 11.7 1.2 1.7 2 0 0 2 2 2 0 TMIE protein Actin PF00022.19 EFO64637.1 - 3.3e-135 450.8 0.0 2.9e-134 447.7 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFO64637.1 - 0.21 10.4 0.0 0.98 8.2 0.0 1.9 2 0 0 2 2 2 0 MreB/Mbl protein Mem_trans PF03547.18 EFO64638.1 - 3.2e-17 62.0 7.5 4.7e-17 61.5 7.5 1.2 1 0 0 1 1 1 1 Membrane transport protein Tetraspanin PF00335.20 EFO64638.1 - 0.55 9.9 8.9 2 8.0 6.5 2.8 1 1 1 2 2 2 0 Tetraspanin family Acyltransferase PF01553.21 EFO64639.1 - 9.2e-12 44.7 0.0 2e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Guanylate_cyc PF00211.20 EFO64640.1 - 2.8e-21 76.0 0.0 6e-13 48.8 0.0 2.4 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain Ank_2 PF12796.7 EFO64641.1 - 3e-88 290.5 36.3 1.3e-06 28.9 0.4 14.3 4 2 9 14 14 14 14 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64641.1 - 1.4e-48 162.3 35.7 3.9e-07 30.2 0.0 16.7 11 4 9 20 20 20 12 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64641.1 - 8e-39 131.5 31.8 0.0033 18.0 0.1 17.3 13 3 4 17 17 17 9 Ankyrin repeats (many copies) Ank PF00023.30 EFO64641.1 - 3.2e-35 119.1 26.3 1.6e-05 25.2 0.0 17.0 16 3 1 17 17 17 9 Ankyrin repeat Ank_3 PF13606.6 EFO64641.1 - 1.7e-32 107.8 32.7 0.0076 16.7 0.0 19.6 21 1 1 22 22 22 7 Ankyrin repeat Pkinase PF00069.25 EFO64641.1 - 1.9e-23 83.2 0.0 4.3e-23 82.0 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64641.1 - 9.4e-14 51.3 0.0 1.8e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Auts2 PF15336.6 EFO64641.1 - 0.023 14.8 2.2 0.044 13.9 2.2 1.4 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein ORC6 PF05460.13 EFO64641.1 - 0.19 11.0 6.0 0.32 10.2 6.0 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) PGBA_C PF15437.6 EFO64641.1 - 1.2 9.6 15.5 2.6 8.5 15.5 1.5 1 0 0 1 1 1 0 Plasminogen-binding protein pgbA C-terminal BTV_NS2 PF04514.12 EFO64642.1 - 0.056 12.3 0.0 0.088 11.6 0.0 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Pkinase PF00069.25 EFO64643.1 - 9.2e-21 74.4 0.0 1.8e-20 73.4 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64643.1 - 4.4e-14 52.4 0.0 6.8e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase VSP PF03302.13 EFO64644.1 - 1.1e-23 83.7 9.7 1.2e-23 83.7 9.7 1.0 1 0 0 1 1 1 1 Giardia variant-specific surface protein SKG6 PF08693.10 EFO64644.1 - 0.0016 17.8 4.6 0.0021 17.4 4.6 1.1 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Podoplanin PF05808.11 EFO64644.1 - 0.024 14.8 1.6 0.024 14.8 1.6 1.0 1 0 0 1 1 1 0 Podoplanin PARM PF17061.5 EFO64644.1 - 0.24 11.5 1.4 0.25 11.5 1.4 1.0 1 0 0 1 1 1 0 PARM YebO PF13974.6 EFO64644.1 - 0.47 10.6 0.9 0.52 10.4 0.9 1.1 1 0 0 1 1 1 0 YebO-like protein Y_phosphatase PF00102.27 EFO64645.1 - 5e-26 91.7 6.8 8.8e-13 48.4 0.1 3.3 3 0 0 3 3 3 2 Protein-tyrosine phosphatase DSPc PF00782.20 EFO64645.1 - 0.0029 17.4 0.0 0.0091 15.8 0.0 1.9 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EFO64645.1 - 0.022 14.9 0.5 0.33 11.1 0.0 2.6 3 0 0 3 3 3 0 Inositol hexakisphosphate Ran_BP1 PF00638.18 EFO64647.1 - 3e-23 82.4 0.2 4e-23 82.0 0.2 1.1 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 EFO64647.1 - 0.011 15.6 0.1 0.03 14.3 0.1 1.7 1 1 0 1 1 1 0 WH1 domain Pkinase PF00069.25 EFO64648.1 - 9.4e-56 189.1 0.1 1.7e-28 99.7 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64648.1 - 2.3e-31 109.0 0.3 6.9e-16 58.3 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFO64648.1 - 0.045 12.5 0.0 0.076 11.8 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EFO64648.1 - 0.12 11.9 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Metallophos_2 PF12850.7 EFO64649.1 - 1.7e-07 31.5 0.0 2.9e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Ank_2 PF12796.7 EFO64650.1 - 4.3e-68 225.9 15.2 4.2e-19 68.9 0.3 5.7 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64650.1 - 2.5e-42 141.5 1.8 2.2e-05 24.7 0.0 10.4 7 2 3 10 10 10 9 Ankyrin repeat Ank_4 PF13637.6 EFO64650.1 - 1.8e-39 133.6 9.0 3.7e-10 40.1 0.0 7.8 7 2 2 9 9 9 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO64650.1 - 4.8e-36 122.4 12.5 5.1e-06 26.7 0.0 10.0 1 1 9 10 10 10 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64650.1 - 3.6e-34 112.9 3.4 0.0026 18.1 0.0 10.4 10 0 0 10 10 10 8 Ankyrin repeat CARD PF00619.21 EFO64650.1 - 0.062 13.3 0.0 0.23 11.5 0.0 1.9 1 0 0 1 1 1 0 Caspase recruitment domain DUF2516 PF10724.9 EFO64650.1 - 0.34 11.2 1.3 3.6 7.9 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2516) HEAT_2 PF13646.6 EFO64650.1 - 0.53 10.7 3.4 4.2 7.8 0.1 3.3 2 1 1 3 3 3 0 HEAT repeats Ank_2 PF12796.7 EFO64651.1 - 1.5e-31 108.8 2.5 9.7e-12 45.3 0.1 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64651.1 - 3.5e-19 68.6 1.5 8.2e-06 26.0 0.0 4.8 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64651.1 - 6.6e-19 68.0 0.2 1.8e-05 25.1 0.0 5.4 5 1 1 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO64651.1 - 5.5e-17 61.4 0.1 0.01 16.2 0.0 6.2 4 2 1 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EFO64651.1 - 7.9e-17 59.6 0.2 0.042 14.4 0.0 6.0 5 0 0 5 5 5 5 Ankyrin repeat RRM_Rrp7 PF17799.1 EFO64651.1 - 0.011 15.5 0.1 0.04 13.7 0.1 1.9 1 0 0 1 1 1 0 Rrp7 RRM-like N-terminal domain SlyX PF04102.12 EFO64651.1 - 0.027 15.1 4.6 0.027 15.1 4.6 5.1 7 0 0 7 7 6 0 SlyX PKcGMP_CC PF16808.5 EFO64651.1 - 0.032 14.1 2.5 0.15 11.9 0.4 2.9 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF3881 PF12997.7 EFO64651.1 - 0.034 13.4 0.2 0.24 10.6 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3881) YkyA PF10368.9 EFO64651.1 - 0.036 13.7 0.3 0.036 13.7 0.3 2.9 3 0 0 3 3 3 0 Putative cell-wall binding lipoprotein IFT20 PF14931.6 EFO64651.1 - 0.053 13.7 7.2 0.86 9.8 0.1 3.3 3 0 0 3 3 3 0 Intraflagellar transport complex B, subunit 20 CENP-K PF11802.8 EFO64651.1 - 0.066 12.8 4.6 4.3 6.8 0.2 2.6 1 1 1 2 2 2 0 Centromere-associated protein K Spc7 PF08317.11 EFO64651.1 - 1.3 7.8 21.9 1.5 7.7 1.0 3.4 3 1 0 3 3 3 0 Spc7 kinetochore protein DUF1664 PF07889.12 EFO64651.1 - 4.9 7.2 20.9 0.37 10.8 0.5 5.8 3 2 2 6 6 6 0 Protein of unknown function (DUF1664) Prefoldin_2 PF01920.20 EFO64651.1 - 7.5 6.6 16.4 0.18 11.8 0.4 4.8 5 0 0 5 5 5 0 Prefoldin subunit Occludin_ELL PF07303.13 EFO64651.1 - 9.4 7.0 6.8 29 5.5 0.0 4.0 4 1 0 4 4 4 0 Occludin homology domain ANTAR PF03861.14 EFO64653.1 - 0.07 13.0 0.3 17 5.3 0.0 2.7 3 0 0 3 3 3 0 ANTAR domain DUF4205 PF13898.6 EFO64655.1 - 2.8e-30 105.5 0.0 1e-22 80.6 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4205) LisH PF08513.11 EFO64655.1 - 0.057 13.4 0.8 0.057 13.4 0.8 2.1 2 0 0 2 2 2 0 LisH BTK PF00779.19 EFO64656.1 - 0.015 15.1 5.0 0.064 13.1 5.0 2.2 1 1 0 1 1 1 0 BTK motif Ank_2 PF12796.7 EFO64657.1 - 1.5e-90 297.8 29.4 1.9e-09 38.0 0.1 11.6 5 3 7 12 12 12 11 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64657.1 - 2.9e-46 154.9 25.8 7.5e-05 22.9 0.0 16.8 9 6 8 17 17 17 14 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64657.1 - 3.3e-45 151.9 19.8 0.0015 19.1 0.0 13.7 9 4 3 14 14 14 12 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64657.1 - 2e-43 141.4 19.6 0.073 13.7 0.0 18.8 19 0 0 19 19 19 10 Ankyrin repeat Ank PF00023.30 EFO64657.1 - 3e-40 134.9 20.9 0.034 14.6 0.1 17.2 16 1 0 16 16 16 13 Ankyrin repeat Pkinase PF00069.25 EFO64657.1 - 3.7e-23 82.2 0.1 3.1e-18 66.1 0.1 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64657.1 - 6.6e-14 51.8 0.0 9.5e-11 41.5 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase EGF_2 PF07974.13 EFO64659.1 - 3.7e-07 30.4 284.7 0.0013 19.1 3.6 23.2 24 1 0 24 24 24 14 EGF-like domain EGF PF00008.27 EFO64659.1 - 0.00076 19.7 13.6 0.0024 18.1 5.0 22.8 23 0 0 23 23 23 13 EGF-like domain UQ_con PF00179.26 EFO64660.1 - 1.3e-34 118.8 0.0 1.5e-34 118.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.11 EFO64660.1 - 0.019 14.6 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 UEV PF05743.13 EFO64660.1 - 0.12 12.2 0.1 0.25 11.2 0.1 1.5 1 1 0 1 1 1 0 UEV domain Cyclin_N PF00134.23 EFO64661.1 - 3.1e-29 101.3 0.3 4.5e-28 97.5 0.0 2.3 2 1 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFO64661.1 - 2.7e-23 82.3 0.5 8.7e-23 80.7 0.1 2.0 2 0 0 2 2 2 1 Cyclin, C-terminal domain CPL PF08144.11 EFO64662.1 - 0.00045 20.6 0.7 0.094 13.1 0.4 3.5 2 1 0 2 2 2 1 CPL (NUC119) domain PUF PF00806.19 EFO64662.1 - 0.0071 16.0 0.0 1 9.2 0.0 3.5 3 0 0 3 3 3 1 Pumilio-family RNA binding repeat DUF2335 PF10097.9 EFO64662.1 - 0.0072 16.3 1.9 0.024 14.6 1.9 1.9 1 0 0 1 1 1 1 Predicted membrane protein (DUF2335) DUF4637 PF15470.6 EFO64662.1 - 0.12 12.1 2.2 0.2 11.3 2.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Lipid_DES PF08557.10 EFO64662.1 - 0.24 10.9 1.0 0.66 9.5 0.5 2.0 2 0 0 2 2 2 0 Sphingolipid Delta4-desaturase (DES) RNA_pol_Rbc25 PF08292.12 EFO64663.1 - 1e-27 96.9 0.0 2.4e-27 95.7 0.0 1.5 2 0 0 2 2 2 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EFO64663.1 - 5.3e-14 52.3 0.0 2.2e-13 50.3 0.0 1.9 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Guanylate_cyc PF00211.20 EFO64666.1 - 2.7e-31 108.6 0.7 8.1e-21 74.5 0.0 3.2 3 0 0 3 3 3 2 Adenylate and Guanylate cyclase catalytic domain Noc2 PF03715.13 EFO64667.1 - 5.6e-16 58.7 1.9 1.3e-15 57.5 0.6 2.1 2 0 0 2 2 2 1 Noc2p family DUF4200 PF13863.6 EFO64668.1 - 0.0012 19.3 11.7 0.0012 19.3 11.7 5.6 6 1 0 6 6 6 1 Domain of unknown function (DUF4200) PKcGMP_CC PF16808.5 EFO64668.1 - 0.58 10.1 10.3 0.097 12.5 1.7 3.6 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase HHH_5 PF14520.6 EFO64669.1 - 1.6e-06 28.7 0.0 3e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain Rad10 PF03834.14 EFO64669.1 - 0.00017 21.5 0.0 0.00066 19.7 0.0 2.0 2 1 0 2 2 2 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_2 PF12826.7 EFO64669.1 - 0.032 14.3 0.0 0.062 13.4 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif Sigma70_r4_2 PF08281.12 EFO64669.1 - 0.063 13.0 0.0 0.16 11.7 0.0 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 LSM PF01423.22 EFO64670.1 - 2.9e-07 30.1 0.0 3.2e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EFO64670.1 - 0.026 14.2 0.0 0.041 13.5 0.0 1.4 1 0 0 1 1 1 0 Hfq protein dsDNA_bind PF01984.20 EFO64671.1 - 2.1e-19 69.8 0.4 3.1e-19 69.3 0.4 1.2 1 0 0 1 1 1 1 Double-stranded DNA-binding domain adh_short PF00106.25 EFO64673.1 - 0.00036 20.0 0.0 0.051 13.0 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase NmrA PF05368.13 EFO64673.1 - 0.0039 16.8 0.2 0.0073 15.9 0.1 1.5 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EFO64673.1 - 0.084 12.8 0.2 0.12 12.2 0.2 1.3 1 0 0 1 1 1 0 NAD(P)H-binding NTP_transferase PF00483.23 EFO64674.1 - 3.5e-10 39.9 0.0 6.7e-05 22.6 0.0 2.2 2 0 0 2 2 2 2 Nucleotidyl transferase Ank_2 PF12796.7 EFO64675.1 - 6.5e-42 142.0 0.5 6.3e-16 58.7 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64675.1 - 9.7e-22 76.4 0.1 0.0061 17.0 0.0 5.3 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 EFO64675.1 - 1.1e-21 76.9 0.2 5.4e-07 30.0 0.0 4.7 4 3 1 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64675.1 - 1.7e-21 74.0 0.4 0.0022 18.3 0.0 5.5 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 EFO64675.1 - 1e-19 70.3 2.1 0.0038 17.5 0.0 5.1 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO64676.1 - 8.3e-39 133.5 0.0 1.5e-38 132.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64676.1 - 7e-30 104.2 0.0 1.1e-29 103.5 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFO64676.1 - 0.0035 17.3 0.0 0.005 16.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFO64676.1 - 0.015 14.6 0.0 0.022 14.1 0.0 1.4 1 1 0 1 1 1 0 Kinase-like Phi29_Phage_SSB PF17427.2 EFO64677.1 - 0.034 14.4 0.1 0.13 12.4 0.1 2.0 1 0 0 1 1 1 0 Phage Single-stranded DNA-binding protein DUF3452 PF11934.8 EFO64677.1 - 0.072 12.6 0.0 0.61 9.6 0.0 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3452) Ank_2 PF12796.7 EFO64678.1 - 1.3e-50 169.8 19.1 6.2e-13 49.2 0.2 4.8 2 1 5 7 7 7 6 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO64678.1 - 2.7e-24 86.0 0.0 5.7e-24 84.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 EFO64678.1 - 4e-23 81.5 3.7 0.00015 22.2 0.0 7.2 6 3 2 8 8 8 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO64678.1 - 4.5e-22 77.8 7.1 0.00016 21.9 0.0 6.9 2 2 5 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64678.1 - 2e-20 70.7 1.7 0.47 11.2 0.0 9.2 9 0 0 9 9 9 6 Ankyrin repeat Pkinase_Tyr PF07714.17 EFO64678.1 - 2.2e-17 63.2 0.0 3.8e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank PF00023.30 EFO64678.1 - 1.5e-15 56.8 7.2 0.052 14.0 0.0 8.8 8 1 0 8 8 8 5 Ankyrin repeat TPR_12 PF13424.6 EFO64679.1 - 1.7e-16 60.2 5.8 2.5e-07 30.9 0.0 4.4 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFO64679.1 - 2.7e-12 45.9 6.5 0.003 17.3 0.0 5.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFO64679.1 - 5.8e-09 35.4 8.5 0.027 14.6 0.0 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFO64679.1 - 1.3e-06 28.2 12.5 1.1 9.6 0.0 6.3 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_MalT PF17874.1 EFO64679.1 - 2.8e-06 27.0 0.7 0.0042 16.5 0.0 2.2 1 1 1 2 2 2 2 MalT-like TPR region TPR_10 PF13374.6 EFO64679.1 - 3.8e-05 23.4 6.8 0.3 11.0 0.0 5.5 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFO64679.1 - 0.0005 20.5 7.9 7.6 7.4 0.4 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFO64679.1 - 0.00058 20.5 5.2 48 5.2 0.5 5.4 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFO64679.1 - 0.0013 19.3 4.8 5.4 7.8 0.0 4.5 4 1 0 4 4 4 1 Tetratricopeptide repeat SPO22 PF08631.10 EFO64679.1 - 0.0014 18.2 2.9 0.21 11.1 0.0 2.9 1 1 1 3 3 3 2 Meiosis protein SPO22/ZIP4 like TPR_7 PF13176.6 EFO64679.1 - 0.0017 18.3 3.2 2 8.6 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat 14-3-3 PF00244.20 EFO64679.1 - 0.016 14.7 0.1 0.016 14.7 0.1 2.4 2 1 1 3 3 3 0 14-3-3 protein TPR_17 PF13431.6 EFO64679.1 - 0.021 15.2 1.2 32 5.2 0.0 4.5 5 1 0 5 5 5 0 Tetratricopeptide repeat DUF2225 PF09986.9 EFO64679.1 - 0.11 12.3 4.3 0.23 11.2 0.4 2.3 1 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) Acyltransferase PF01553.21 EFO64681.1 - 2.3e-10 40.2 0.0 4.4e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase VSP PF03302.13 EFO64682.1 - 1e-44 153.0 183.1 8.8e-30 103.8 68.6 6.7 1 1 3 4 4 4 4 Giardia variant-specific surface protein ASH PF15780.5 EFO64683.1 - 0.018 15.3 0.0 0.82 9.9 0.0 2.9 2 0 0 2 2 2 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin rve PF00665.26 EFO64687.1 - 0.073 13.3 0.2 0.18 12.0 0.2 1.7 1 1 0 1 1 1 0 Integrase core domain LCAT PF02450.15 EFO64690.1 - 8e-13 48.3 0.0 1.9e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 EFO64690.1 - 1e-05 24.9 0.0 2e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EFO64690.1 - 0.00089 19.0 0.0 0.0065 16.2 0.0 2.4 2 1 0 2 2 2 1 PGAP1-like protein DUF676 PF05057.14 EFO64690.1 - 0.0012 18.4 0.0 0.0025 17.3 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_1 PF00561.20 EFO64690.1 - 0.0027 17.4 0.0 0.0082 15.8 0.0 1.8 1 0 0 1 1 1 1 alpha/beta hydrolase fold Palm_thioest PF02089.15 EFO64690.1 - 0.014 15.3 0.0 0.032 14.1 0.0 1.6 1 0 0 1 1 1 0 Palmitoyl protein thioesterase NS3_envE PF02723.14 EFO64690.1 - 3.2 7.9 8.2 7.7 6.7 8.2 1.6 1 0 0 1 1 1 0 Non-structural protein NS3/Small envelope protein E FKBP_C PF00254.28 EFO64691.1 - 1.7e-05 25.0 0.0 2.7e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Calcipressin PF04847.12 EFO64692.1 - 0.073 12.8 1.9 0.11 12.3 0.7 1.8 2 0 0 2 2 2 0 Calcipressin WD40 PF00400.32 EFO64693.1 - 0.00069 20.4 0.0 8.7 7.4 0.0 4.9 5 0 0 5 5 5 1 WD domain, G-beta repeat PQQ_3 PF13570.6 EFO64693.1 - 0.042 14.4 0.0 0.51 10.9 0.0 2.5 2 0 0 2 2 2 0 PQQ-like domain DUF2415 PF10313.9 EFO64693.1 - 0.17 11.8 0.0 5.2 7.1 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised protein domain (DUF2415) Ist1 PF03398.14 EFO64694.1 - 7.5e-06 26.0 0.0 1.1e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway AAA PF00004.29 EFO64695.1 - 4.1e-88 292.6 0.0 7.5e-44 149.4 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFO64695.1 - 6.7e-25 86.6 7.1 4.3e-13 48.8 0.3 3.5 3 0 0 3 3 3 2 AAA+ lid domain CDC48_N PF02359.18 EFO64695.1 - 1.1e-12 47.9 0.0 2.7e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 EFO64695.1 - 1.3e-10 41.2 0.0 0.00054 19.7 0.0 3.3 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EFO64695.1 - 3.9e-10 40.4 0.1 0.00011 22.8 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_2 PF07724.14 EFO64695.1 - 4.4e-10 39.9 0.0 2.2e-05 24.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EFO64695.1 - 1.4e-09 38.6 0.1 0.0026 18.1 0.0 3.5 2 1 1 3 3 3 2 AAA ATPase domain TIP49 PF06068.13 EFO64695.1 - 7.2e-09 35.3 0.0 0.00052 19.3 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 EFO64695.1 - 9.2e-09 35.6 0.0 0.0053 16.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 EFO64695.1 - 2e-08 34.8 0.0 0.027 15.0 0.0 3.5 3 0 0 3 3 3 2 ABC transporter AAA_14 PF13173.6 EFO64695.1 - 2.2e-08 34.2 0.0 0.0042 17.1 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_5 PF07728.14 EFO64695.1 - 3.3e-08 33.6 0.1 0.0091 16.0 0.0 3.4 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFO64695.1 - 1.1e-07 32.2 0.9 0.043 14.1 0.2 4.0 2 2 0 2 2 2 2 AAA domain AAA_17 PF13207.6 EFO64695.1 - 3.2e-07 30.9 0.2 0.026 15.0 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_28 PF13521.6 EFO64695.1 - 6.8e-07 29.7 0.1 0.0054 17.0 0.0 2.7 3 0 0 3 3 2 2 AAA domain Rad17 PF03215.15 EFO64695.1 - 7.8e-07 29.2 0.0 0.0053 16.7 0.0 2.7 2 0 0 2 2 2 2 Rad17 P-loop domain Viral_helicase1 PF01443.18 EFO64695.1 - 1.7e-06 28.0 0.0 0.057 13.1 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase DUF815 PF05673.13 EFO64695.1 - 2e-06 27.2 0.0 0.0022 17.2 0.0 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 EFO64695.1 - 4.3e-06 27.1 0.0 0.12 12.8 0.0 2.9 3 0 0 3 3 2 2 RNA helicase IstB_IS21 PF01695.17 EFO64695.1 - 4.7e-06 26.5 0.2 0.064 13.0 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein SKI PF01202.22 EFO64695.1 - 1e-05 25.7 0.7 0.053 13.6 0.0 3.1 3 0 0 3 3 2 2 Shikimate kinase AAA_24 PF13479.6 EFO64695.1 - 3e-05 23.8 0.0 0.059 13.1 0.0 2.9 2 0 0 2 2 2 2 AAA domain NTPase_1 PF03266.15 EFO64695.1 - 4.5e-05 23.4 0.1 0.085 12.8 0.0 4.0 4 0 0 4 4 4 1 NTPase Mg_chelatase PF01078.21 EFO64695.1 - 4.6e-05 22.9 0.3 0.24 10.7 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 EFO64695.1 - 8.2e-05 22.3 0.0 0.75 9.6 0.0 3.1 3 0 0 3 3 3 2 P-loop containing region of AAA domain CDC48_2 PF02933.17 EFO64695.1 - 0.00017 21.3 0.0 0.00062 19.5 0.0 2.0 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), domain 2 Parvo_NS1 PF01057.17 EFO64695.1 - 0.00038 19.6 0.1 0.26 10.3 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Vps4_C PF09336.10 EFO64695.1 - 0.00046 20.1 1.0 0.0094 15.9 0.1 2.8 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_7 PF12775.7 EFO64695.1 - 0.0007 19.2 0.0 1.4 8.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region Zeta_toxin PF06414.12 EFO64695.1 - 0.00071 18.9 0.0 0.33 10.2 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin TsaE PF02367.17 EFO64695.1 - 0.00073 19.5 0.0 1.2 9.2 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 EFO64695.1 - 0.00079 18.8 0.2 1 8.6 0.3 2.9 2 1 0 2 2 2 1 KaiC Cytidylate_kin PF02224.18 EFO64695.1 - 0.0008 19.2 0.2 0.84 9.3 0.0 2.5 2 0 0 2 2 2 2 Cytidylate kinase Sigma54_activat PF00158.26 EFO64695.1 - 0.00089 19.0 0.0 3.2 7.4 0.0 3.1 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_30 PF13604.6 EFO64695.1 - 0.00099 18.9 0.0 0.54 10.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EFO64695.1 - 0.0011 18.5 0.1 2.2 7.8 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.6 EFO64695.1 - 0.0021 18.4 0.0 0.33 11.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EFO64695.1 - 0.0025 17.7 3.3 2.7 7.7 0.0 3.6 4 0 0 4 4 4 1 AAA domain NACHT PF05729.12 EFO64695.1 - 0.0028 17.6 0.5 2.2 8.2 0.1 2.9 3 0 0 3 3 2 1 NACHT domain DUF2075 PF09848.9 EFO64695.1 - 0.0034 16.7 0.0 2.2 7.4 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 EFO64695.1 - 0.0052 16.7 0.1 0.41 10.5 0.0 3.1 2 2 1 3 3 2 1 ATPase domain predominantly from Archaea Sigma54_activ_2 PF14532.6 EFO64695.1 - 0.0068 16.5 0.0 3.3 7.8 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain NB-ARC PF00931.22 EFO64695.1 - 0.013 14.7 0.0 1.5 8.0 0.0 2.6 2 0 0 2 2 2 0 NB-ARC domain Cytidylate_kin2 PF13189.6 EFO64695.1 - 0.013 15.6 1.0 2 8.5 0.0 2.7 3 0 0 3 3 2 0 Cytidylate kinase-like family AAA_3 PF07726.11 EFO64695.1 - 0.03 14.2 0.0 10 6.0 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 EFO64695.1 - 0.043 14.3 0.3 2.1 8.8 0.0 2.9 3 0 0 3 3 2 0 AAA domain ADK PF00406.22 EFO64695.1 - 0.068 13.3 0.5 14 5.8 0.1 2.9 3 0 0 3 3 2 0 Adenylate kinase TniB PF05621.11 EFO64695.1 - 0.088 12.2 0.0 6.9 6.0 0.0 3.2 4 0 0 4 4 4 0 Bacterial TniB protein T2SSE PF00437.20 EFO64695.1 - 0.13 11.3 0.0 3.6 6.6 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein PhoH PF02562.16 EFO64695.1 - 0.18 11.2 0.3 6.8 6.1 0.0 2.6 2 0 0 2 2 2 0 PhoH-like protein Hydin_ADK PF17213.3 EFO64695.1 - 3.8 7.7 7.2 1.6 8.9 0.0 3.3 4 0 0 4 4 4 0 Hydin Adenylate kinase-like domain Lyase_8 PF02278.18 EFO64696.1 - 8.3e-10 38.6 0.9 1.8e-09 37.4 0.9 1.6 1 0 0 1 1 1 1 Polysaccharide lyase family 8, super-sandwich domain Peptidase_S49_N PF08496.10 EFO64696.1 - 0.031 14.3 1.2 0.067 13.3 1.2 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal EphA2_TM PF14575.6 EFO64696.1 - 0.2 12.6 0.5 0.58 11.1 0.5 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Chs7 PF12271.8 EFO64697.1 - 0.057 12.8 0.3 0.093 12.1 0.3 1.2 1 0 0 1 1 1 0 Chitin synthase export chaperone Ank_2 PF12796.7 EFO64698.1 - 6.5e-88 289.4 45.2 6.3e-14 52.3 1.0 9.4 2 2 9 11 11 11 11 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64698.1 - 2.9e-55 182.4 33.2 2.9e-05 24.3 0.1 16.6 15 1 1 16 16 16 13 Ankyrin repeat Ank_5 PF13857.6 EFO64698.1 - 1e-48 162.7 30.9 3.9e-07 30.2 0.0 15.4 4 3 14 18 18 18 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64698.1 - 3.5e-45 146.7 24.2 0.0094 16.4 0.0 17.7 18 0 0 18 18 18 12 Ankyrin repeat Ank_4 PF13637.6 EFO64698.1 - 1.3e-42 143.6 23.9 5.4e-06 26.8 0.1 12.9 8 4 5 13 13 13 12 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO64698.1 - 1.9e-14 53.7 0.0 3.1e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64698.1 - 7.7e-06 25.4 0.1 1.9e-05 24.1 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase CdAMP_rec PF06153.11 EFO64698.1 - 0.047 13.9 0.2 0.4 10.9 0.0 2.6 3 0 0 3 3 3 0 Cyclic-di-AMP receptor UQ_con PF00179.26 EFO64699.1 - 2.5e-27 95.3 0.0 2.7e-27 95.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFO64699.1 - 0.077 13.3 0.0 0.091 13.1 0.0 1.2 1 0 0 1 1 1 0 RWD domain Ank_2 PF12796.7 EFO64700.1 - 3e-23 82.2 3.0 1.9e-12 47.6 0.2 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64700.1 - 1.2e-11 44.4 5.5 0.11 13.0 0.0 6.8 7 1 0 7 7 6 3 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO64700.1 - 7.6e-11 41.7 7.1 1.3e-10 41.0 7.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Ank_5 PF13857.6 EFO64700.1 - 3.6e-10 39.9 4.8 0.28 11.5 0.3 5.9 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64700.1 - 4.6e-09 35.8 3.0 1.3 9.8 0.0 6.5 7 0 0 7 7 6 1 Ankyrin repeat Ank_4 PF13637.6 EFO64700.1 - 4.1e-08 33.6 3.4 0.00025 21.6 0.0 4.7 2 2 3 5 5 5 2 Ankyrin repeats (many copies) zf-RING_2 PF13639.6 EFO64700.1 - 1.4e-06 28.5 9.7 2.9e-06 27.5 9.7 1.6 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EFO64700.1 - 0.0001 22.1 6.7 0.00018 21.3 6.7 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFO64700.1 - 0.00016 21.5 7.9 0.00033 20.6 7.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFO64700.1 - 0.00026 20.8 8.8 0.00026 20.8 8.8 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFO64700.1 - 0.021 14.6 5.2 0.039 13.7 2.2 2.5 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_2 PF13923.6 EFO64700.1 - 0.024 14.5 9.8 0.024 14.5 9.8 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-P11 PF03854.14 EFO64700.1 - 0.032 13.9 2.9 0.032 13.9 2.9 2.8 2 1 1 3 3 3 0 P-11 zinc finger Mltc_N PF11873.8 EFO64700.1 - 0.13 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Membrane-bound lytic murein transglycosylase C, N-terminal domain RecR PF02132.15 EFO64700.1 - 0.55 9.8 9.3 9.1 5.9 0.1 2.5 2 0 0 2 2 2 0 RecR protein zf-MIZ PF02891.20 EFO64700.1 - 1.6 8.5 9.3 7.2 6.4 8.0 2.3 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger zf-RING_UBOX PF13445.6 EFO64700.1 - 2.1 8.4 7.0 0.9 9.6 1.8 2.4 2 0 0 2 2 2 0 RING-type zinc-finger TMEM154 PF15102.6 EFO64701.1 - 0.16 11.9 0.4 0.23 11.4 0.0 1.5 2 0 0 2 2 2 0 TMEM154 protein family Ank_2 PF12796.7 EFO64702.1 - 1.7e-32 111.8 6.8 2e-08 34.7 0.1 5.1 3 1 3 6 6 6 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64702.1 - 5.3e-19 68.0 3.7 0.00041 20.6 0.0 7.2 2 1 5 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO64702.1 - 7.9e-19 67.2 2.1 0.04 14.4 0.0 7.8 7 0 0 7 7 7 5 Ankyrin repeat Pkinase PF00069.25 EFO64702.1 - 3.4e-18 66.0 0.0 6.7e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 EFO64702.1 - 2e-17 63.3 4.0 0.00075 20.0 0.0 5.9 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64702.1 - 5.4e-17 60.2 6.1 0.29 11.8 0.0 8.1 7 0 0 7 7 7 5 Ankyrin repeat Pkinase_Tyr PF07714.17 EFO64702.1 - 1.1e-10 41.2 0.0 9.8e-10 38.1 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase RIIa PF02197.17 EFO64703.1 - 0.017 14.8 0.0 0.085 12.5 0.0 2.2 2 0 0 2 2 2 0 Regulatory subunit of type II PKA R-subunit Cren7 PF11520.8 EFO64705.1 - 0.17 11.8 0.0 0.42 10.6 0.0 1.6 1 0 0 1 1 1 0 Chromatin protein Cren7 zf-CHY PF05495.12 EFO64706.1 - 9.3e-13 48.5 13.8 9.3e-13 48.5 13.8 4.4 2 1 1 3 3 3 1 CHY zinc finger Csm1 PF12539.8 EFO64706.1 - 0.084 13.5 0.0 0.21 12.2 0.0 1.6 1 0 0 1 1 1 0 Chromosome segregation protein Csm1/Pcs1 Ank_2 PF12796.7 EFO64707.1 - 6.6e-136 443.2 29.6 7.5e-16 58.5 0.1 13.5 1 1 13 14 14 14 14 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64707.1 - 1.8e-86 283.4 22.3 1.9e-09 37.8 0.0 18.7 10 6 10 20 20 20 16 Ankyrin repeats (many copies) Ank PF00023.30 EFO64707.1 - 5.8e-82 266.8 31.7 9.9e-05 22.6 0.0 24.7 23 1 2 25 25 25 16 Ankyrin repeat Ank_5 PF13857.6 EFO64707.1 - 3.6e-78 256.6 29.8 3.7e-05 23.9 0.1 19.3 7 5 12 20 20 20 17 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64707.1 - 1e-75 240.6 20.2 0.00085 19.6 0.0 24.6 23 2 2 25 25 25 15 Ankyrin repeat Pkinase PF00069.25 EFO64707.1 - 2.1e-37 128.9 0.0 7.1e-37 127.2 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64707.1 - 2.2e-26 92.7 0.0 4.9e-26 91.6 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFO64707.1 - 0.0016 18.4 0.0 0.0037 17.2 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fez1 PF06818.15 EFO64707.1 - 0.0081 16.6 0.6 0.019 15.4 0.6 1.6 1 0 0 1 1 1 1 Fez1 HOOK PF05622.12 EFO64707.1 - 0.019 13.1 0.5 0.031 12.4 0.5 1.2 1 0 0 1 1 1 0 HOOK protein APG6_N PF17675.1 EFO64707.1 - 0.087 13.4 1.4 0.25 11.9 1.4 1.8 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF641 PF04859.12 EFO64707.1 - 0.26 11.6 1.0 1 9.7 1.0 2.0 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) TMF_DNA_bd PF12329.8 EFO64707.1 - 0.42 10.7 5.4 0.4 10.7 2.2 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding HemY_N PF07219.13 EFO64707.1 - 0.5 10.6 9.9 1.2 9.4 0.0 4.7 4 0 0 4 4 4 0 HemY protein N-terminus DUF3881 PF12997.7 EFO64707.1 - 1.5 8.0 8.4 12 5.1 0.0 4.1 4 1 0 4 4 4 0 Domain of unknown function, E. rectale Gene description (DUF3881) Phage_T7_Capsid PF05396.11 EFO64707.1 - 2 8.8 5.4 1.8 8.9 0.0 3.6 4 0 0 4 4 4 0 Phage T7 capsid assembly protein ABC_tran_CTD PF16326.5 EFO64707.1 - 3.8 7.8 6.6 24 5.2 4.3 2.6 2 0 0 2 2 2 0 ABC transporter C-terminal domain Peptidase_M16_M PF16187.5 EFO64708.1 - 0.013 14.8 0.1 0.02 14.2 0.1 1.2 1 0 0 1 1 1 0 Middle or third domain of peptidase_M16 Na_Ala_symp PF01235.17 EFO64709.1 - 0.0056 16.0 3.7 0.0068 15.8 3.7 1.0 1 0 0 1 1 1 1 Sodium:alanine symporter family POR_N PF01855.19 EFO64710.1 - 1.8e-72 243.8 1.4 7.3e-72 241.9 2.1 1.6 2 0 0 2 2 2 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg POR PF01558.18 EFO64710.1 - 8.1e-33 114.0 0.3 2.2e-32 112.5 0.3 1.8 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase PFOR_II PF17147.4 EFO64710.1 - 5.3e-10 39.5 0.1 1.9e-09 37.8 0.1 2.0 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Fer4_7 PF12838.7 EFO64710.1 - 1e-09 38.9 6.3 3.5e-09 37.1 6.3 2.1 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4 PF00037.27 EFO64710.1 - 8.1e-09 34.9 17.8 1.6e-05 24.5 3.3 3.3 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_6 PF12837.7 EFO64710.1 - 6.9e-07 29.1 17.2 0.00018 21.4 2.1 3.6 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_16 PF13484.6 EFO64710.1 - 2.4e-06 28.4 5.3 0.0066 17.3 0.4 2.7 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 EFO64710.1 - 2.5e-06 27.5 9.9 0.00012 22.2 10.8 2.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 EFO64710.1 - 4e-06 26.8 12.7 0.0018 18.4 1.3 3.3 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 EFO64710.1 - 9.7e-06 25.9 7.8 3.4e-05 24.2 7.8 2.0 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 EFO64710.1 - 1.1e-05 25.9 6.5 3.9e-05 24.1 6.5 2.1 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EFO64710.1 - 1.6e-05 24.9 7.1 1.6e-05 24.9 7.1 2.3 2 1 0 2 2 2 1 4Fe-4S dicluster domain TPP_enzyme_C PF02775.21 EFO64710.1 - 3.9e-05 23.5 0.1 0.00016 21.5 0.1 2.1 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Fer4_2 PF12797.7 EFO64710.1 - 4.9e-05 23.2 16.3 0.0094 16.0 3.1 3.5 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_4 PF12800.7 EFO64710.1 - 0.0005 20.4 11.7 0.02 15.4 0.8 3.0 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_3 PF12798.7 EFO64710.1 - 0.84 10.7 20.0 0.24 12.4 6.2 3.1 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_18 PF13746.6 EFO64710.1 - 1.2 9.3 7.1 1.7 8.8 5.6 2.0 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 EFO64710.1 - 3.6 8.2 11.3 14 6.3 2.2 2.8 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_15 PF13459.6 EFO64710.1 - 5.2 7.9 7.5 6.7 7.5 1.0 2.9 2 0 0 2 2 2 0 4Fe-4S single cluster domain Annexin PF00191.20 EFO64711.1 - 1.8e-22 79.1 1.4 4.2e-08 33.1 0.0 4.4 4 1 0 4 4 4 4 Annexin MOR2-PAG1_C PF14225.6 EFO64711.1 - 0.17 11.7 0.1 0.27 11.1 0.1 1.3 1 0 0 1 1 1 0 Cell morphogenesis C-terminal AAA_14 PF13173.6 EFO64712.1 - 0.08 13.0 0.1 0.27 11.3 0.0 1.8 1 1 1 2 2 2 0 AAA domain SMC_N PF02463.19 EFO64713.1 - 1.5e-61 207.6 0.0 3.2e-61 206.6 0.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFO64713.1 - 8.7e-11 42.2 3.9 6.1e-05 23.0 0.1 2.7 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFO64713.1 - 1.1e-08 35.8 9.5 1.1e-08 35.8 9.5 4.7 3 1 0 3 3 3 1 AAA domain AAA_15 PF13175.6 EFO64713.1 - 4.4e-07 29.9 0.3 4.4e-07 29.9 0.3 3.6 2 2 0 3 3 2 2 AAA ATPase domain SMC_hinge PF06470.13 EFO64713.1 - 6.3e-07 29.7 0.1 1.8e-06 28.2 0.1 1.8 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_29 PF13555.6 EFO64713.1 - 0.00017 21.3 0.1 0.00051 19.7 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF4164 PF13747.6 EFO64713.1 - 0.0076 16.5 6.5 0.0076 16.5 6.5 4.6 3 1 0 3 3 3 1 Domain of unknown function (DUF4164) LuxT_C PF18285.1 EFO64713.1 - 0.14 12.7 1.9 5.4 7.6 0.0 3.9 3 0 0 3 3 3 0 Tetracycline repressor LuxT C-terminal domain SLATT_1 PF18181.1 EFO64713.1 - 0.36 10.8 3.0 4.2 7.3 0.7 4.0 3 1 1 4 4 4 0 SMODS and SLOG-associating 2TM effector domain 1 ABC_tran PF00005.27 EFO64713.1 - 0.43 11.1 9.9 2.5 8.6 0.1 4.1 4 1 0 4 4 4 0 ABC transporter DUF1664 PF07889.12 EFO64713.1 - 2.3 8.3 27.5 0.45 10.5 4.7 5.1 3 2 1 4 4 4 0 Protein of unknown function (DUF1664) DUF3158 PF11358.8 EFO64713.1 - 2.8 7.7 9.7 1.7 8.4 0.2 4.4 3 1 1 4 4 4 0 Protein of unknown function (DUF3158) Ank_2 PF12796.7 EFO64715.1 - 1e-25 90.1 2.2 2.2e-13 50.6 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64715.1 - 6.4e-14 51.9 3.0 1.9e-05 24.9 0.1 4.8 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64715.1 - 9.2e-14 50.2 2.8 0.011 16.2 0.0 4.8 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 EFO64715.1 - 2.2e-13 50.0 2.8 0.0056 17.1 0.1 4.4 3 1 1 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EFO64715.1 - 9.6e-12 45.2 0.1 1.6e-06 28.5 0.2 3.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) DUF327 PF03885.13 EFO64715.1 - 0.025 14.5 0.3 0.025 14.5 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF327) AAA PF00004.29 EFO64716.1 - 1.7e-31 109.4 0.0 5.6e-31 107.7 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFO64716.1 - 8.8e-05 22.2 0.2 0.00025 20.8 0.2 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFO64716.1 - 0.00058 19.9 0.0 0.0018 18.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFO64716.1 - 0.00065 20.0 1.0 0.24 11.7 0.2 2.9 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFO64716.1 - 0.0009 19.7 0.1 0.0037 17.7 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 EFO64716.1 - 0.0046 16.7 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RuvB_N PF05496.12 EFO64716.1 - 0.014 15.2 0.0 0.028 14.2 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain PhoH PF02562.16 EFO64716.1 - 0.022 14.2 0.2 0.045 13.2 0.2 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.6 EFO64716.1 - 0.038 13.6 0.0 0.34 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EFO64716.1 - 0.094 12.1 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 EFO64716.1 - 0.1 12.1 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EFO64716.1 - 0.12 12.0 0.2 0.3 10.8 0.2 1.6 1 1 0 1 1 1 0 AAA domain Rdx PF10262.9 EFO64719.1 - 1.4e-11 44.4 0.0 1.5e-11 44.3 0.0 1.0 1 0 0 1 1 1 1 Rdx family ALMT PF11744.8 EFO64720.1 - 0.67 8.7 4.4 0.85 8.4 4.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Fez1 PF06818.15 EFO64721.1 - 1 9.8 19.6 0.049 14.1 4.6 2.5 2 0 0 2 2 2 0 Fez1 Pkinase PF00069.25 EFO64722.1 - 5e-24 85.1 0.0 1e-23 84.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64722.1 - 7.8e-13 48.3 0.0 1.4e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PUFD PF16553.5 EFO64723.1 - 0.0066 16.6 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 BCORL-PCGF1-binding domain DUF1335 PF07056.11 EFO64723.1 - 0.031 14.4 0.1 0.068 13.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1335) Tap-RNA_bind PF09162.10 EFO64723.1 - 0.15 11.9 0.0 0.35 10.7 0.0 1.6 1 0 0 1 1 1 0 Tap, RNA-binding Radical_SAM PF04055.21 EFO64724.1 - 6.4e-19 68.9 0.0 1.3e-18 67.9 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 EFO64724.1 - 0.025 14.7 0.8 0.17 12.0 0.3 2.5 2 0 0 2 2 2 0 4Fe-4S single cluster domain Ank_2 PF12796.7 EFO64725.1 - 7.2e-65 215.6 13.7 2.3e-13 50.5 0.1 9.2 3 3 7 10 10 10 10 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO64725.1 - 5.7e-42 143.9 0.0 9.9e-42 143.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ank PF00023.30 EFO64725.1 - 8.9e-32 108.1 6.5 5.2e-05 23.5 0.0 11.9 12 1 1 13 13 11 5 Ankyrin repeat Ank_5 PF13857.6 EFO64725.1 - 2.4e-31 107.4 13.5 8.8e-05 22.7 0.1 12.1 10 3 5 15 15 14 8 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64725.1 - 6.7e-28 96.7 8.7 8e-06 26.3 0.1 11.1 9 3 3 12 12 12 6 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO64725.1 - 3.3e-26 92.1 0.0 6.5e-26 91.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_3 PF13606.6 EFO64725.1 - 2.9e-22 76.4 12.0 0.021 15.3 0.1 14.1 15 0 0 15 15 15 3 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO64725.1 - 4e-09 36.2 12.3 1e-08 34.9 12.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFO64725.1 - 8.9e-05 22.8 13.6 0.00026 21.3 13.6 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFO64725.1 - 0.00023 20.9 13.6 0.00072 19.4 13.6 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFO64725.1 - 0.028 14.3 13.0 0.13 12.1 13.1 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO64725.1 - 0.12 12.3 11.7 0.38 10.6 11.7 2.0 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Kinesin PF00225.23 EFO64726.1 - 1.8e-105 352.6 0.0 2.5e-105 352.1 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFO64726.1 - 1.3e-18 67.4 0.0 3.1e-18 66.2 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Med3 PF11593.8 EFO64726.1 - 0.064 12.4 0.1 0.12 11.6 0.1 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Kinesin_assoc PF16183.5 EFO64726.1 - 0.091 12.9 5.4 6.5 6.9 0.0 3.4 3 1 0 4 4 4 0 Kinesin-associated DUF87 PF01935.17 EFO64726.1 - 1.4 9.0 6.2 8.6 6.4 0.6 2.9 3 0 0 3 3 3 0 Helicase HerA, central domain SIKE PF05769.11 EFO64726.1 - 7 6.5 8.2 23 4.9 6.7 2.6 2 1 0 2 2 2 0 SIKE family Cpn60_TCP1 PF00118.24 EFO64727.1 - 4.6e-144 480.7 5.4 6e-144 480.3 5.4 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Peripla_BP_2 PF01497.18 EFO64727.1 - 0.13 11.8 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Periplasmic binding protein CDC50 PF03381.15 EFO64728.1 - 3e-33 115.6 5.0 7e-33 114.3 2.5 2.6 1 1 1 2 2 2 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF2721 PF11026.8 EFO64728.1 - 8.9 6.2 8.5 4.1 7.3 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Fez1 PF06818.15 EFO64729.1 - 0.00069 20.1 61.7 0.23 11.9 20.5 4.3 2 2 2 4 4 4 3 Fez1 DASH_Dam1 PF08653.10 EFO64729.1 - 0.017 14.9 0.2 2.6 7.9 0.0 3.6 2 0 0 2 2 2 0 DASH complex subunit Dam1 TolA_bind_tri PF16331.5 EFO64729.1 - 0.36 10.9 0.1 0.36 10.9 0.1 6.3 5 1 1 6 6 6 0 TolA binding protein trimerisation DUF1664 PF07889.12 EFO64729.1 - 4.2 7.4 38.6 0.29 11.2 3.9 5.8 5 1 2 7 7 7 0 Protein of unknown function (DUF1664) Ank_2 PF12796.7 EFO64730.1 - 1.9e-89 294.3 40.7 3.7e-15 56.3 0.1 13.4 8 2 4 14 14 14 14 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64730.1 - 2.3e-37 126.6 32.4 5.7e-05 23.3 0.0 18.4 15 5 7 22 22 22 11 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64730.1 - 1.9e-33 114.4 31.9 0.00011 22.7 0.4 18.5 11 6 10 22 22 22 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64730.1 - 2.6e-31 104.2 36.9 0.02 15.4 0.0 20.3 22 0 0 22 22 22 8 Ankyrin repeat Ank PF00023.30 EFO64730.1 - 4.3e-31 106.0 32.1 0.1 13.1 0.0 19.3 20 2 0 20 20 20 10 Ankyrin repeat Pkinase PF00069.25 EFO64730.1 - 5.4e-08 32.5 0.0 3.3e-07 30.0 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64730.1 - 0.065 12.5 0.0 0.42 9.9 0.0 2.2 2 0 0 2 2 2 0 Protein tyrosine kinase DIM1 PF02966.16 EFO64731.1 - 4.3e-46 156.0 0.0 4.8e-46 155.8 0.0 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 ATG16 PF08614.11 EFO64732.1 - 0.0005 20.4 11.7 0.0005 20.4 11.7 3.5 2 1 1 3 3 3 1 Autophagy protein 16 (ATG16) Flavodoxin_4 PF12682.7 EFO64732.1 - 0.074 12.8 0.3 0.15 11.8 0.3 1.4 1 0 0 1 1 1 0 Flavodoxin FlaC_arch PF05377.11 EFO64732.1 - 1.1 9.7 5.4 33 5.0 0.0 4.5 4 1 2 6 6 6 0 Flagella accessory protein C (FlaC) Arg_decarbox_C PF17944.1 EFO64732.1 - 3.6 8.2 7.2 15 6.2 0.9 4.0 4 0 0 4 4 4 0 Arginine decarboxylase C-terminal helical extension PSI PF01437.25 EFO64733.1 - 1.5e-07 31.8 72.2 0.0016 19.0 9.9 5.5 4 1 1 5 5 5 4 Plexin repeat PSI_integrin PF17205.3 EFO64733.1 - 0.0098 15.6 11.6 0.0098 15.6 11.6 6.0 5 1 0 5 5 5 3 Integrin plexin domain FAM176 PF14851.6 EFO64733.1 - 0.014 15.0 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 FAM176 family OAD_gamma PF04277.13 EFO64733.1 - 0.23 12.1 0.1 0.23 12.1 0.1 1.8 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF3285 PF11688.8 EFO64733.1 - 0.64 10.0 2.7 0.66 9.9 1.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3285) Annexin_like PF18411.1 EFO64735.1 - 0.16 12.3 0.1 3.1 8.1 0.0 3.0 4 0 0 4 4 4 0 Annexin-like domain Ank_2 PF12796.7 EFO64736.1 - 1.2e-30 105.9 4.3 2.1e-10 41.1 0.0 3.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64736.1 - 4.4e-14 52.4 2.2 0.0017 18.6 0.0 4.7 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO64736.1 - 7.3e-10 38.8 0.2 0.39 11.2 0.1 4.8 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 EFO64736.1 - 1.8e-09 37.9 1.9 0.00069 20.1 0.1 4.8 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64736.1 - 1.2e-08 34.5 1.2 0.043 14.4 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat TPK_catalytic PF04263.16 EFO64737.1 - 4.8e-18 65.3 0.0 9.1e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 EFO64737.1 - 0.00056 19.6 0.0 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain DUF3654 PF12376.8 EFO64740.1 - 0.029 14.6 0.9 0.29 11.3 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3654) 5TM-5TMR_LYT PF07694.12 EFO64740.1 - 0.13 11.8 2.1 0.15 11.5 0.7 1.9 2 0 0 2 2 2 0 5TMR of 5TMR-LYT DUF5615 PF18480.1 EFO64741.1 - 0.085 12.6 0.0 5.5 6.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5615) RRM_1 PF00076.22 EFO64742.1 - 9.3e-05 22.2 0.0 0.00028 20.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ComGF PF15980.5 EFO64742.1 - 0.35 11.2 5.0 9.7 6.6 0.0 3.2 3 0 0 3 3 3 0 Putative Competence protein ComGF Prefoldin_2 PF01920.20 EFO64743.1 - 4.5e-08 33.0 2.9 7.8e-08 32.2 2.9 1.4 1 1 0 1 1 1 1 Prefoldin subunit ETC_C1_NDUFA5 PF04716.14 EFO64743.1 - 0.01 15.6 0.7 0.035 13.9 0.7 2.2 1 1 0 1 1 1 0 ETC complex I subunit conserved region RasGAP_C PF03836.15 EFO64743.1 - 0.12 12.6 3.7 0.8 9.9 3.7 1.9 1 1 0 1 1 1 0 RasGAP C-terminus Seryl_tRNA_N PF02403.22 EFO64743.1 - 0.36 11.1 8.0 4.8 7.5 0.2 2.0 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Spc24 PF08286.11 EFO64743.1 - 1.2 9.4 4.8 1.4 9.2 0.3 2.0 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Ribosomal_S8e PF01201.22 EFO64744.1 - 1.2e-39 135.6 3.3 1.2e-39 135.6 3.3 1.4 1 1 0 1 1 1 1 Ribosomal protein S8e DUF2839 PF10999.8 EFO64744.1 - 0.19 12.1 2.0 0.49 10.8 0.2 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2839) GD_AH_C PF04295.13 EFO64746.1 - 0.15 10.8 0.0 0.21 10.3 0.0 1.2 1 0 0 1 1 1 0 D-galactarate dehydratase / Altronate hydrolase, C terminus Pkinase PF00069.25 EFO64747.1 - 3.4e-31 108.6 0.0 6.3e-22 78.2 0.0 3.1 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64747.1 - 2.1e-15 56.8 0.1 1.1e-14 54.4 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase DUF4476 PF14771.6 EFO64749.1 - 0.0014 18.9 0.7 0.0029 17.9 0.0 1.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4476) CDC45 PF02724.14 EFO64750.1 - 1.4e-15 56.7 0.2 1.4e-15 56.7 0.2 3.1 2 1 0 2 2 2 1 CDC45-like protein DUF667 PF05018.13 EFO64751.1 - 1.1e-87 292.6 0.5 1.2e-87 292.4 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF667) Zn_protease PF05618.11 EFO64751.1 - 0.07 13.0 0.0 0.099 12.5 0.0 1.2 1 0 0 1 1 1 0 Putative ATP-dependant zinc protease DUF4407 PF14362.6 EFO64752.1 - 0.32 10.3 18.8 0.42 9.9 12.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) GIT_CC PF16559.5 EFO64752.1 - 0.4 10.6 13.8 1.3 9.0 0.1 4.3 4 1 1 5 5 5 0 GIT coiled-coil Rho guanine nucleotide exchange factor UPF0242 PF06785.11 EFO64752.1 - 0.86 9.7 28.8 0.28 11.3 8.5 3.3 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Filament PF00038.21 EFO64752.1 - 1 8.8 27.3 0.24 10.9 3.5 3.5 2 1 1 3 3 3 0 Intermediate filament protein DUF948 PF06103.11 EFO64752.1 - 1.5 9.1 4.5 19 5.6 0.2 3.2 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) PilO PF04350.13 EFO64752.1 - 1.8 8.7 0.0 1.8 8.7 0.0 3.7 3 1 1 4 4 4 0 Pilus assembly protein, PilO CENP-F_leu_zip PF10473.9 EFO64752.1 - 4.2 7.4 29.8 1.5 8.8 6.1 3.5 2 2 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Baculo_PEP_C PF04513.12 EFO64752.1 - 7 6.7 12.4 30 4.6 0.6 3.4 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TBCA PF02970.16 EFO64752.1 - 7.1 7.0 18.9 0.48 10.8 6.0 3.5 4 1 0 4 4 4 0 Tubulin binding cofactor A RRN3 PF05327.11 EFO64753.1 - 1.2e-24 86.8 0.0 7.6e-24 84.2 0.0 2.0 1 1 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Ank_2 PF12796.7 EFO64754.1 - 1.7e-29 102.2 4.3 3e-10 40.5 0.1 3.8 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO64754.1 - 3.1e-17 60.9 4.0 0.0035 17.7 0.0 7.5 8 0 0 8 8 8 5 Ankyrin repeat Ank_5 PF13857.6 EFO64754.1 - 1e-15 57.6 2.5 0.0093 16.3 0.0 6.2 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64754.1 - 1.7e-12 47.6 1.7 0.009 16.6 0.0 6.2 4 2 2 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO64754.1 - 2.4e-11 43.5 2.7 0.06 13.8 0.0 6.4 7 0 0 7 7 7 3 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO64754.1 - 3.5e-06 26.8 19.1 9.5e-06 25.4 19.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PP2C PF00481.21 EFO64755.1 - 5.9e-70 235.8 0.0 1e-60 205.6 0.0 2.0 1 1 1 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 EFO64755.1 - 6.4e-05 22.7 0.0 0.00021 21.0 0.0 2.2 1 1 0 1 1 1 1 Protein phosphatase 2C RVT_1 PF00078.27 EFO64757.1 - 5.2e-28 98.1 0.0 7.7e-28 97.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_9 PF16293.5 EFO64757.1 - 0.0021 17.8 0.7 0.0053 16.6 0.7 1.6 1 0 0 1 1 1 1 C2H2 type zinc-finger (1 copy) PAPS_reduct PF01507.19 EFO64757.1 - 0.025 14.6 0.1 0.95 9.5 0.1 2.3 2 0 0 2 2 2 0 Phosphoadenosine phosphosulfate reductase family zf-met PF12874.7 EFO64757.1 - 0.09 13.2 0.1 0.24 11.9 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger of C2H2 type MCM_OB PF17207.3 EFO64757.1 - 0.099 12.5 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 MCM OB domain Ank_2 PF12796.7 EFO64759.1 - 4.9e-25 87.9 2.2 9.4e-11 42.2 0.1 2.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64759.1 - 6.4e-14 51.8 0.0 2.7e-05 24.4 0.0 3.3 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64759.1 - 6.5e-12 44.5 0.0 0.15 12.7 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 EFO64759.1 - 1.2e-10 41.4 0.0 0.1 13.1 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EFO64759.1 - 3e-07 30.9 0.2 0.0034 17.9 0.0 3.7 2 1 3 5 5 5 4 Ankyrin repeats (many copies) YchF-GTPase_C PF06071.13 EFO64760.1 - 5.7e-32 109.8 0.1 9.1e-32 109.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF933) Nnf1 PF03980.14 EFO64761.1 - 0.35 11.3 4.0 4.6 7.7 0.6 3.3 2 0 0 2 2 2 0 Nnf1 Ank_2 PF12796.7 EFO64762.1 - 1.7e-76 252.8 24.3 1.1e-11 45.2 0.1 9.2 2 2 8 10 10 10 10 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64762.1 - 7e-42 140.9 19.9 0.00068 19.9 0.0 14.2 5 3 8 14 14 14 10 Ankyrin repeats (many copies) Ank PF00023.30 EFO64762.1 - 3.8e-37 125.1 11.1 0.0064 16.9 0.0 14.1 14 1 0 14 14 14 8 Ankyrin repeat Ank_3 PF13606.6 EFO64762.1 - 9.4e-37 120.9 12.4 0.079 13.6 0.0 15.5 16 0 0 16 16 16 9 Ankyrin repeat Ank_4 PF13637.6 EFO64762.1 - 5.2e-36 122.6 17.7 1e-07 32.3 0.0 13.2 8 4 7 15 15 15 9 Ankyrin repeats (many copies) DivIVA PF05103.13 EFO64762.1 - 0.0018 18.3 2.0 0.0018 18.3 2.0 3.0 3 1 0 3 3 3 1 DivIVA protein SlyX PF04102.12 EFO64762.1 - 0.69 10.6 4.1 15 6.3 1.5 3.0 2 0 0 2 2 2 0 SlyX COG5 PF10392.9 EFO64762.1 - 1.6 8.9 7.9 0.58 10.3 2.2 2.8 1 1 2 3 3 3 0 Golgi transport complex subunit 5 Golgin_A5 PF09787.9 EFO64762.1 - 4.8 6.6 14.1 6.2 6.2 2.8 2.4 1 1 0 2 2 2 0 Golgin subfamily A member 5 Spc7 PF08317.11 EFO64763.1 - 0.0013 17.7 104.0 0.0058 15.5 17.9 7.8 4 1 4 8 8 8 6 Spc7 kinetochore protein Fez1 PF06818.15 EFO64763.1 - 0.063 13.7 83.9 0.18 12.2 15.3 6.9 4 1 3 7 7 7 0 Fez1 TPR_MLP1_2 PF07926.12 EFO64763.1 - 0.42 10.7 101.8 0.073 13.1 14.3 7.4 5 1 4 9 9 9 0 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 EFO64764.1 - 0.04 14.4 2.6 0.05 14.1 2.6 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region CENP-H PF05837.12 EFO64764.1 - 0.044 14.2 0.8 0.054 13.9 0.8 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Cpn10 PF00166.21 EFO64766.1 - 0.0067 16.5 0.0 0.0082 16.2 0.0 1.2 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Lyase_8 PF02278.18 EFO64767.1 - 3e-17 62.9 0.1 5.4e-17 62.1 0.1 1.4 1 0 0 1 1 1 1 Polysaccharide lyase family 8, super-sandwich domain Lyase_8_N PF08124.11 EFO64767.1 - 3.2e-09 36.2 1.9 2.1e-08 33.5 1.9 2.0 1 1 0 1 1 1 1 Polysaccharide lyase family 8, N terminal alpha-helical domain Lyase_8_C PF02884.17 EFO64767.1 - 5.1e-06 26.9 0.3 1.3e-05 25.5 0.3 1.7 1 0 0 1 1 1 1 Polysaccharide lyase family 8, C-terminal beta-sandwich domain DUF2173 PF09941.9 EFO64767.1 - 0.13 12.5 0.0 0.39 11.0 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2173) Shisa PF13908.6 EFO64768.1 - 0.00095 19.5 0.6 0.0018 18.5 0.6 1.5 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator FliP PF00813.20 EFO64768.1 - 0.021 14.7 0.2 0.036 13.9 0.2 1.3 1 0 0 1 1 1 0 FliP family HEAT PF02985.22 EFO64769.1 - 0.36 11.2 6.2 1.8 9.0 0.1 4.5 5 0 0 5 5 5 0 HEAT repeat MatE PF01554.18 EFO64771.1 - 0.0092 15.6 7.1 0.0092 15.6 7.1 4.2 2 2 1 4 4 4 2 MatE DUF3847 PF12958.7 EFO64771.1 - 0.05 13.7 3.2 0.096 12.8 3.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) Ank_2 PF12796.7 EFO64772.1 - 8.4e-52 173.7 10.7 7.6e-19 68.1 1.9 5.0 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64772.1 - 3.4e-30 104.0 12.5 2.4e-05 24.8 0.4 7.5 6 2 2 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO64772.1 - 5.2e-24 84.0 12.9 3.2e-05 24.1 0.6 8.4 3 2 6 9 9 9 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO64772.1 - 5.4e-24 83.5 18.4 0.00013 22.3 0.2 9.5 9 1 1 10 10 10 6 Ankyrin repeat Ank_3 PF13606.6 EFO64772.1 - 5.8e-24 81.6 16.8 0.001 19.4 0.1 10.2 8 2 2 10 10 9 5 Ankyrin repeat AIG1 PF04548.16 EFO64772.1 - 1.6e-10 40.7 0.6 0.0025 17.2 0.0 3.5 3 0 0 3 3 3 3 AIG1 family MMR_HSR1 PF01926.23 EFO64772.1 - 4.1e-07 30.1 0.4 1.5e-05 25.1 0.2 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase Septin PF00735.18 EFO64772.1 - 0.00068 19.0 0.1 0.0044 16.4 0.1 2.3 1 1 0 1 1 1 1 Septin RsgA_GTPase PF03193.16 EFO64772.1 - 0.00083 19.3 0.0 0.0029 17.5 0.0 1.9 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EFO64772.1 - 0.013 15.0 0.1 1.3 8.5 0.0 2.7 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_29 PF13555.6 EFO64772.1 - 0.017 14.8 0.0 0.064 13.0 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF3570 PF12094.8 EFO64772.1 - 0.052 12.3 0.0 0.15 10.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3570) Sigma54_activat PF00158.26 EFO64772.1 - 0.08 12.6 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF87 PF01935.17 EFO64772.1 - 0.094 12.8 3.9 0.6 10.2 0.0 3.4 3 1 1 4 4 4 0 Helicase HerA, central domain ABC_tran PF00005.27 EFO64772.1 - 0.11 13.0 0.1 0.54 10.8 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_23 PF13476.6 EFO64772.1 - 0.27 11.7 2.4 2.3 8.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EFO64772.1 - 0.4 9.8 3.2 0.95 8.6 0.0 2.8 4 0 0 4 4 4 0 NB-ARC domain Dynamin_N PF00350.23 EFO64772.1 - 0.45 10.5 4.1 4.8 7.2 0.6 3.1 2 1 0 2 2 2 0 Dynamin family AIG1 PF04548.16 EFO64773.1 - 3.1e-06 26.7 0.9 0.04 13.2 0.0 2.9 3 0 0 3 3 3 2 AIG1 family MMR_HSR1 PF01926.23 EFO64773.1 - 8.5e-06 25.8 0.0 4.1e-05 23.6 0.0 2.2 2 1 0 2 2 1 1 50S ribosome-binding GTPase Septin PF00735.18 EFO64773.1 - 0.00023 20.5 0.0 0.00067 19.0 0.0 1.7 1 1 0 1 1 1 1 Septin AAA_10 PF12846.7 EFO64773.1 - 0.00031 19.8 0.1 0.19 10.6 0.0 2.3 2 0 0 2 2 2 2 AAA-like domain RsgA_GTPase PF03193.16 EFO64773.1 - 0.00086 19.2 0.1 0.0053 16.7 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EFO64773.1 - 0.0012 19.3 0.1 0.033 14.6 0.0 2.8 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EFO64773.1 - 0.0021 18.3 0.2 0.047 14.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.20 EFO64773.1 - 0.0033 16.6 2.8 0.017 14.3 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit AAA_29 PF13555.6 EFO64773.1 - 0.0054 16.5 0.1 0.014 15.2 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EFO64773.1 - 0.0067 16.9 0.1 0.036 14.6 0.0 2.2 2 0 0 2 2 2 1 ABC transporter AAA_24 PF13479.6 EFO64773.1 - 0.027 14.2 0.0 0.42 10.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain Ras PF00071.22 EFO64773.1 - 0.027 14.1 0.1 0.11 12.1 0.0 2.1 3 0 0 3 3 2 0 Ras family Roc PF08477.13 EFO64773.1 - 0.029 14.6 0.0 0.076 13.2 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EFO64773.1 - 0.065 13.3 2.1 8.6 6.4 0.0 3.8 3 1 0 3 3 3 0 Dynamin family GTP_EFTU PF00009.27 EFO64773.1 - 0.068 12.7 0.1 0.21 11.1 0.1 1.8 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain PhoU PF01895.19 EFO64773.1 - 0.085 13.3 0.2 0.47 10.9 0.1 2.4 2 0 0 2 2 1 0 PhoU domain AAA_23 PF13476.6 EFO64773.1 - 0.09 13.3 5.4 0.43 11.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EFO64773.1 - 0.09 12.3 0.0 0.24 10.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 EFO64773.1 - 0.13 12.0 0.0 0.48 10.1 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 EFO64774.1 - 0.12 12.9 0.3 3.6 8.1 0.0 3.0 2 1 0 2 2 2 0 ABC transporter Sigma_reg_N PF13800.6 EFO64774.1 - 0.69 10.2 4.2 1.3 9.3 1.7 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal HECT PF00632.25 EFO64775.1 - 2e-54 185.2 0.1 1.4e-53 182.4 0.0 2.2 2 1 0 2 2 2 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 EFO64775.1 - 2.4e-05 24.5 0.0 5.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A Se-cys_synth_N PF12390.8 EFO64776.1 - 0.1 12.8 0.2 0.17 12.1 0.2 1.4 1 0 0 1 1 1 0 Selenocysteine synthase N terminal Helicase_C PF00271.31 EFO64777.1 - 1.7e-08 34.8 0.3 1.4e-07 31.9 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFO64777.1 - 5.6e-07 29.5 0.0 0.00036 20.3 0.0 2.9 2 0 0 2 2 2 2 DEAD/DEAH box helicase HA2 PF04408.23 EFO64777.1 - 0.0086 16.3 1.0 0.026 14.8 0.0 2.4 2 0 0 2 2 2 1 Helicase associated domain (HA2) AAA_22 PF13401.6 EFO64777.1 - 0.11 12.8 0.1 50 4.1 0.0 3.5 3 0 0 3 3 3 0 AAA domain LRS4 PF10422.9 EFO64777.1 - 2.3 7.7 6.4 0.99 8.9 0.2 2.5 1 1 1 2 2 2 0 Monopolin complex subunit LRS4 Fez1 PF06818.15 EFO64778.1 - 1.4e-06 28.9 25.9 0.0012 19.3 9.0 2.2 2 0 0 2 2 2 2 Fez1 BRE1 PF08647.11 EFO64778.1 - 0.0054 16.8 32.6 0.0065 16.5 18.3 3.4 2 1 1 3 3 3 2 BRE1 E3 ubiquitin ligase Phage_GP20 PF06810.11 EFO64778.1 - 0.053 13.3 0.7 0.053 13.3 0.7 3.8 2 2 1 3 3 3 0 Phage minor structural protein GP20 GAS PF13851.6 EFO64778.1 - 0.1 12.0 37.7 0.075 12.4 10.5 3.6 2 2 1 3 3 3 0 Growth-arrest specific micro-tubule binding V-SNARE_C PF12352.8 EFO64778.1 - 0.57 10.5 9.4 0.14 12.5 0.7 3.3 3 0 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus TMF_TATA_bd PF12325.8 EFO64778.1 - 1.3 9.3 31.3 1.1 9.5 11.6 3.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding PspA_IM30 PF04012.12 EFO64778.1 - 1.8 8.1 36.3 1.6 8.3 10.6 4.1 1 1 3 4 4 4 0 PspA/IM30 family FlaC_arch PF05377.11 EFO64778.1 - 1.8 9.0 18.2 4.4 7.8 0.4 5.1 2 2 1 4 4 4 0 Flagella accessory protein C (FlaC) Lebercilin PF15619.6 EFO64778.1 - 1.8 8.1 38.9 0.82 9.3 0.5 3.4 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease TMPIT PF07851.13 EFO64778.1 - 2.2 7.4 19.4 0.4 9.9 5.1 2.8 2 1 1 3 3 3 0 TMPIT-like protein 5_nucleotid PF05761.14 EFO64778.1 - 3 6.6 18.8 0.1 11.5 4.5 2.4 2 1 0 2 2 2 0 5' nucleotidase family DUF4618 PF15397.6 EFO64778.1 - 4 6.8 32.4 0.29 10.5 14.9 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) TolA_bind_tri PF16331.5 EFO64778.1 - 4.2 7.5 22.5 1.8 8.7 0.7 4.5 2 2 1 4 4 4 0 TolA binding protein trimerisation Csm1_N PF18504.1 EFO64778.1 - 5.9 7.3 29.1 0.31 11.4 5.4 5.6 2 2 3 5 5 5 0 Csm1 N-terminal domain DASH_Dam1 PF08653.10 EFO64778.1 - 6 6.7 9.1 49 3.8 0.1 4.3 4 1 1 5 5 5 0 DASH complex subunit Dam1 USP8_interact PF08941.10 EFO64778.1 - 6.5 6.5 21.8 0.42 10.4 2.8 3.9 2 2 3 5 5 5 0 USP8 interacting Golgin_A5 PF09787.9 EFO64778.1 - 6.7 6.1 36.5 7 6.0 15.2 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 CEP63 PF17045.5 EFO64778.1 - 8.4 6.2 33.7 15 5.4 27.1 2.5 1 1 2 3 3 3 0 Centrosomal protein of 63 kDa YafO_toxin PF13957.6 EFO64780.1 - 0.092 12.8 0.2 0.3 11.1 0.0 1.9 2 0 0 2 2 2 0 Toxin YafO, type II toxin-antitoxin system SIKE PF05769.11 EFO64781.1 - 0.0017 18.4 13.4 0.0017 18.4 13.4 3.1 2 1 1 3 3 3 1 SIKE family TolA_bind_tri PF16331.5 EFO64781.1 - 0.018 15.1 3.7 0.018 15.1 3.7 4.2 3 2 1 4 4 4 0 TolA binding protein trimerisation Shugoshin_N PF07558.11 EFO64781.1 - 0.031 14.1 0.7 0.031 14.1 0.7 2.3 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region IFT57 PF10498.9 EFO64781.1 - 3.2 6.6 25.0 0.015 14.3 12.8 2.3 2 1 0 2 2 2 0 Intra-flagellar transport protein 57 DUF4201 PF13870.6 EFO64781.1 - 3.7 7.3 23.9 0.23 11.2 13.4 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) Leu_zip PF15294.6 EFO64781.1 - 4.6 6.7 26.8 6.7 6.1 2.2 3.1 2 1 0 2 2 2 0 Leucine zipper FTA4 PF13093.6 EFO64781.1 - 7.6 6.4 16.3 0.078 12.9 1.7 2.5 2 1 0 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 COG2 PF06148.11 EFO64781.1 - 7.9 6.6 13.8 0.14 12.3 3.5 2.9 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Metallophos PF00149.28 EFO64782.1 - 1e-28 101.3 0.0 1.5e-28 100.8 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF5378 PF17349.2 EFO64782.1 - 0.061 12.6 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5378) RNA_pol_Rpb4 PF03874.16 EFO64783.1 - 0.0014 19.0 0.1 0.0042 17.4 0.1 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb4 Cgr1 PF03879.14 EFO64784.1 - 4.4e-06 27.0 18.2 5.4e-06 26.7 18.2 1.1 1 0 0 1 1 1 1 Cgr1 family WGG PF10273.9 EFO64785.1 - 5.3e-13 49.4 0.1 8.2e-13 48.8 0.1 1.3 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 PCC_BT PF18140.1 EFO64785.1 - 0.12 12.8 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 Propionyl-coenzyme A carboxylase BT domain XET_C PF06955.12 EFO64787.1 - 0.0045 16.8 0.3 1.3 8.9 0.5 2.9 2 0 0 2 2 2 1 Xyloglucan endo-transglycosylase (XET) C-terminus HWE_HK PF07536.14 EFO64787.1 - 0.059 14.1 3.6 0.42 11.3 0.1 3.9 4 1 0 4 4 4 0 HWE histidine kinase MutS_IV PF05190.18 EFO64787.1 - 0.79 10.1 5.2 1.9 8.9 0.3 3.5 2 1 0 2 2 2 0 MutS family domain IV GrpE PF01025.19 EFO64787.1 - 1.9 8.1 26.2 9.5 5.8 14.6 5.1 2 1 2 5 5 5 0 GrpE NPV_P10 PF05531.12 EFO64787.1 - 1.9 9.0 17.9 20 5.7 0.0 5.3 6 1 0 6 6 6 0 Nucleopolyhedrovirus P10 protein APG6_N PF17675.1 EFO64787.1 - 2.8 8.5 33.0 1.3 9.5 1.7 5.0 4 2 1 5 5 5 0 Apg6 coiled-coil region VirDNA-topo-I_N PF09266.10 EFO64790.1 - 0.06 13.5 0.7 4.3 7.6 0.1 4.1 5 0 0 5 5 5 0 Viral DNA topoisomerase I, N-terminal Ribosomal_L37e PF01907.19 EFO64791.1 - 1.6e-25 89.0 12.0 1.6e-25 89.0 12.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L37e EFG_C PF00679.24 EFO64791.1 - 0.022 14.8 0.2 0.037 14.1 0.1 1.5 1 1 1 2 2 2 0 Elongation factor G C-terminus Rubredoxin_2 PF18073.1 EFO64791.1 - 0.048 13.4 4.7 2.6 7.9 0.2 2.4 2 0 0 2 2 2 0 Rubredoxin metal binding domain HypA PF01155.19 EFO64791.1 - 0.065 13.3 0.6 0.11 12.6 0.6 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ribosomal_S14 PF00253.21 EFO64791.1 - 0.34 10.7 8.8 1.7 8.5 0.3 2.5 1 1 1 2 2 2 0 Ribosomal protein S14p/S29e zn-ribbon_14 PF16503.5 EFO64791.1 - 0.48 10.0 4.5 3.6 7.2 0.2 2.3 2 0 0 2 2 2 0 Zinc-ribbon DUF2688 PF10892.8 EFO64791.1 - 2 8.0 5.4 3.9 7.0 1.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2688) Pkinase PF00069.25 EFO64792.1 - 1.1e-63 215.1 0.0 1.4e-63 214.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64792.1 - 2.5e-34 118.7 0.0 7.1e-33 114.0 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFO64792.1 - 0.0034 16.4 0.0 0.0041 16.1 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFO64792.1 - 0.029 14.3 0.8 0.12 12.3 0.0 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family Sua5_yciO_yrdC PF01300.18 EFO64793.1 - 4.1e-50 169.7 0.1 5.9e-50 169.2 0.1 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EFO64793.1 - 6.3e-15 55.9 0.0 1.2e-14 55.0 0.0 1.5 1 1 0 1 1 1 1 Putative GTP-binding controlling metal-binding WD40 PF00400.32 EFO64794.1 - 3.5e-07 30.8 5.5 0.00015 22.5 0.0 4.1 4 0 0 4 4 4 1 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 EFO64794.1 - 4.1e-07 30.1 0.0 9.6e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex DUF3584 PF12128.8 EFO64797.1 - 7.2 4.0 20.1 10 3.5 20.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) NUDIX PF00293.28 EFO64799.1 - 2.1e-07 31.0 0.0 3.6e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain CUB PF00431.20 EFO64799.1 - 0.1 12.9 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 CUB domain Tubulin PF00091.25 EFO64800.1 - 2.7e-48 164.8 0.0 4.2e-48 164.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFO64800.1 - 0.00049 20.3 0.0 0.00086 19.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EFO64800.1 - 0.12 12.7 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain MCM PF00493.23 EFO64801.1 - 3.1e-90 301.2 0.2 5.2e-90 300.5 0.2 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFO64801.1 - 4.7e-24 84.6 0.1 1e-23 83.6 0.1 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFO64801.1 - 4.6e-23 81.4 2.3 7.5e-23 80.8 0.6 2.2 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 EFO64801.1 - 8.1e-10 39.2 0.5 2.3e-09 37.8 0.1 1.9 2 0 0 2 2 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EFO64801.1 - 3.3e-08 33.2 0.0 2.2e-07 30.5 0.0 2.3 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFO64801.1 - 3.8e-06 26.9 0.0 7.5e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFO64801.1 - 0.00015 21.7 0.0 0.00037 20.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFO64801.1 - 0.00073 19.3 0.4 0.003 17.3 0.0 2.1 2 1 0 2 2 2 1 Sigma-54 interaction domain Swm2 PF17083.5 EFO64801.1 - 0.026 14.5 0.4 0.077 13.0 0.4 1.8 1 0 0 1 1 1 0 Nucleolar protein Swm2 DUF3834 PF12916.7 EFO64801.1 - 0.057 12.7 0.0 0.14 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) Zn-ribbon_8 PF09723.10 EFO64801.1 - 0.069 13.3 1.4 0.17 12.0 1.4 1.7 1 0 0 1 1 1 0 Zinc ribbon domain HypA PF01155.19 EFO64801.1 - 0.088 12.8 0.1 0.26 11.3 0.1 1.8 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TF_Zn_Ribbon PF08271.12 EFO64801.1 - 0.95 9.0 4.4 1 8.9 0.1 3.0 2 1 1 3 3 3 0 TFIIB zinc-binding LSM PF01423.22 EFO64802.1 - 1.9e-15 56.3 0.0 2.4e-15 56.0 0.0 1.1 1 0 0 1 1 1 1 LSM domain Glyco_hyd_65N_2 PF14498.6 EFO64802.1 - 0.0071 16.2 0.0 0.0078 16.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain SM-ATX PF14438.6 EFO64802.1 - 0.049 13.8 0.0 0.062 13.4 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain DUF4457 PF14652.6 EFO64803.1 - 2.3e-21 76.4 0.3 8.5e-13 48.2 0.0 3.9 3 1 1 4 4 4 3 Domain of unknown function (DUF4457) ABC_tran PF00005.27 EFO64804.1 - 1.8e-35 122.4 0.4 6.8e-18 65.5 0.0 2.9 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFO64804.1 - 2.8e-16 59.6 1.5 4.6e-06 26.2 0.2 3.7 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFO64804.1 - 3.9e-14 53.2 7.4 0.00082 19.3 0.3 4.3 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system RLI PF04068.15 EFO64804.1 - 1.7e-13 50.1 6.3 4.9e-13 48.6 6.3 1.9 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_29 PF13555.6 EFO64804.1 - 2.8e-08 33.4 0.1 0.0006 19.5 0.0 2.9 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 EFO64804.1 - 2.4e-07 30.8 0.2 0.034 13.9 0.1 3.8 4 0 0 4 4 4 2 AAA ATPase domain Fer4 PF00037.27 EFO64804.1 - 1.3e-06 28.0 3.3 1.3e-06 28.0 3.3 2.6 3 0 0 3 3 3 1 4Fe-4S binding domain AAA_23 PF13476.6 EFO64804.1 - 4.1e-06 27.4 3.3 0.00094 19.7 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFO64804.1 - 4.4e-05 23.9 0.0 0.1 13.0 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EFO64804.1 - 5.5e-05 23.1 3.5 0.027 14.4 0.0 3.4 4 1 0 4 4 2 2 RsgA GTPase AAA_22 PF13401.6 EFO64804.1 - 6.1e-05 23.3 1.5 0.01 16.1 0.0 3.1 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 EFO64804.1 - 0.00029 20.8 0.4 0.066 13.1 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA PF00004.29 EFO64804.1 - 0.0004 20.8 0.7 0.36 11.3 0.1 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Fer4_21 PF14697.6 EFO64804.1 - 0.00062 19.8 12.5 0.0014 18.7 12.5 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain MMR_HSR1 PF01926.23 EFO64804.1 - 0.0013 18.8 1.0 0.17 12.0 0.0 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase Fer4_6 PF12837.7 EFO64804.1 - 0.002 18.1 3.4 0.002 18.1 3.4 3.2 3 0 0 3 3 3 1 4Fe-4S binding domain DUF815 PF05673.13 EFO64804.1 - 0.0025 17.0 0.2 0.013 14.6 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 EFO64804.1 - 0.0031 17.9 0.1 2.2 8.7 0.0 2.8 2 0 0 2 2 2 1 RNA helicase SbcCD_C PF13558.6 EFO64804.1 - 0.0065 16.7 0.0 5.9 7.2 0.0 2.7 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 EFO64804.1 - 0.0065 16.2 1.5 0.26 11.0 0.0 2.8 2 1 0 2 2 2 1 AAA domain Fer4_10 PF13237.6 EFO64804.1 - 0.0071 16.4 1.4 0.0071 16.4 1.4 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain MukB PF04310.12 EFO64804.1 - 0.011 15.6 0.4 0.9 9.3 0.0 3.2 3 0 0 3 3 3 0 MukB N-terminal Fer4_9 PF13187.6 EFO64804.1 - 0.016 15.4 12.7 0.038 14.1 12.7 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_7 PF12838.7 EFO64804.1 - 0.017 15.7 1.6 0.017 15.7 1.6 2.4 1 1 2 3 3 3 0 4Fe-4S dicluster domain AAA_7 PF12775.7 EFO64804.1 - 0.02 14.4 0.2 0.2 11.1 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 EFO64804.1 - 0.022 14.8 1.8 0.81 9.7 0.1 3.0 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EFO64804.1 - 0.023 14.4 0.7 2.4 7.8 0.1 2.5 2 0 0 2 2 2 0 AAA domain VirE PF05272.11 EFO64804.1 - 0.079 12.7 0.1 5.4 6.7 0.0 2.4 2 0 0 2 2 2 0 Virulence-associated protein E Rad17 PF03215.15 EFO64804.1 - 0.08 12.9 0.0 19 5.1 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain NTPase_1 PF03266.15 EFO64804.1 - 0.082 12.8 1.2 1.5 8.7 0.2 2.9 2 0 0 2 2 2 0 NTPase AAA_25 PF13481.6 EFO64804.1 - 0.14 11.8 0.2 1.4 8.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF2813 PF11398.8 EFO64804.1 - 0.17 11.1 0.4 1 8.6 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2813) SRP54 PF00448.22 EFO64804.1 - 0.18 11.4 2.4 8.6 5.9 0.1 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 EFO64804.1 - 0.72 10.0 2.5 3.3 7.9 0.1 2.7 2 1 0 2 2 2 0 AAA domain Fer4_16 PF13484.6 EFO64804.1 - 2.3 9.2 13.0 0.15 13.0 1.7 2.7 1 1 2 3 3 3 0 4Fe-4S double cluster binding domain CLP1_P PF16575.5 EFO64805.1 - 1.4e-05 25.0 0.0 4.1e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop IFT46_B_C PF12317.8 EFO64806.1 - 3e-53 180.7 1.3 7.1e-53 179.5 1.3 1.6 1 1 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal OpuAC PF04069.12 EFO64806.1 - 0.12 11.9 0.5 0.29 10.7 0.1 1.8 2 0 0 2 2 2 0 Substrate binding domain of ABC-type glycine betaine transport system Pkinase PF00069.25 EFO64808.1 - 1.5e-16 60.6 0.5 4.8e-11 42.5 0.4 3.3 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64808.1 - 3.7e-08 33.0 0.3 1.7e-06 27.5 0.2 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFO64808.1 - 0.0087 14.9 0.5 0.035 12.9 0.0 2.3 2 0 0 2 2 2 1 Fungal protein kinase TFIIB PF00382.19 EFO64809.1 - 4.4e-14 52.3 0.0 1.1e-09 38.2 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EFO64809.1 - 1.7e-09 37.0 0.2 3.4e-09 36.1 0.2 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding Lar_restr_allev PF14354.6 EFO64809.1 - 0.017 15.5 0.1 0.055 13.9 0.1 1.8 1 0 0 1 1 1 0 Restriction alleviation protein Lar Ribosomal_S27e PF01667.17 EFO64809.1 - 0.026 14.2 1.0 0.026 14.2 1.0 1.5 2 0 0 2 2 2 0 Ribosomal protein S27 BRF1 PF07741.13 EFO64809.1 - 0.079 13.3 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain zinc_ribbon_4 PF13717.6 EFO64809.1 - 0.093 12.7 0.4 0.18 11.8 0.4 1.5 1 0 0 1 1 1 0 zinc-ribbon domain RepA1_leader PF08048.12 EFO64810.1 - 3 8.2 7.2 0.86 9.9 0.2 2.6 2 0 0 2 2 2 0 Tap RepA1 leader peptide WD40 PF00400.32 EFO64811.1 - 3e-25 88.0 12.0 0.00022 22.0 0.3 8.6 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO64811.1 - 1.3e-07 31.8 2.0 0.33 11.3 0.1 6.0 4 3 4 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain Utp13 PF08625.11 EFO64811.1 - 7.7e-06 25.9 0.1 1.6e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain Ge1_WD40 PF16529.5 EFO64811.1 - 7.9e-05 21.8 2.3 1.7 7.5 0.0 5.0 5 1 2 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EFO64811.1 - 0.0001 21.1 2.7 0.36 9.4 0.1 3.9 4 0 0 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EFO64811.1 - 0.04 13.2 1.8 0.094 12.0 0.5 2.2 2 0 0 2 2 2 0 WD40-like domain WD40_like PF17005.5 EFO64812.1 - 0.12 11.7 0.6 2 7.7 0.0 3.0 3 1 1 4 4 4 0 WD40-like domain Fip1 PF05182.13 EFO64813.1 - 3.4e-15 55.3 0.5 5.2e-15 54.7 0.5 1.3 1 0 0 1 1 1 1 Fip1 motif c-SKI_SMAD_bind PF08782.10 EFO64813.1 - 0.025 14.8 0.0 0.033 14.4 0.0 1.2 1 0 0 1 1 1 0 c-SKI Smad4 binding domain Ank_2 PF12796.7 EFO64814.1 - 8.8e-47 157.6 7.1 1e-15 58.1 0.0 5.0 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO64814.1 - 1.1e-41 143.0 0.0 2.6e-41 141.7 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 EFO64814.1 - 5.7e-29 100.1 3.1 4.7e-06 27.0 0.1 6.9 5 2 2 7 7 7 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO64814.1 - 2.9e-28 97.0 6.1 4.4e-05 23.7 0.0 9.5 7 2 2 9 9 9 5 Ankyrin repeat Ank_5 PF13857.6 EFO64814.1 - 1.4e-26 92.2 8.6 0.009 16.3 0.0 9.0 1 1 8 9 9 9 7 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO64814.1 - 1.9e-24 86.4 0.0 4e-24 85.3 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_3 PF13606.6 EFO64814.1 - 1.9e-24 83.0 0.9 0.044 14.3 0.0 10.2 10 0 0 10 10 9 3 Ankyrin repeat DUF16 PF01519.16 EFO64814.1 - 0.0017 18.8 0.7 0.0058 17.1 0.7 1.9 1 0 0 1 1 1 1 Protein of unknown function DUF16 SlyX PF04102.12 EFO64814.1 - 0.0021 18.6 4.7 0.0083 16.7 4.1 2.4 2 0 0 2 2 1 1 SlyX Kinase-like PF14531.6 EFO64814.1 - 0.0022 17.4 0.0 0.0046 16.3 0.0 1.5 1 0 0 1 1 1 1 Kinase-like DUF641 PF04859.12 EFO64814.1 - 0.0095 16.3 1.7 0.036 14.4 1.7 1.9 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) NPV_P10 PF05531.12 EFO64814.1 - 0.012 16.1 3.2 0.039 14.4 3.2 1.9 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein End3 PF12761.7 EFO64814.1 - 0.016 15.4 2.1 0.03 14.5 2.1 1.4 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Spc7 PF08317.11 EFO64814.1 - 0.025 13.5 2.8 0.044 12.6 2.8 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Atg14 PF10186.9 EFO64814.1 - 0.029 13.5 3.2 0.048 12.8 3.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TolA_bind_tri PF16331.5 EFO64814.1 - 0.029 14.4 9.2 0.079 13.0 9.2 1.8 1 0 0 1 1 1 0 TolA binding protein trimerisation HMMR_N PF15905.5 EFO64814.1 - 0.034 13.6 4.8 0.059 12.8 4.8 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Cnn_1N PF07989.11 EFO64814.1 - 0.037 14.2 2.9 0.19 11.9 2.9 2.2 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 APH PF01636.23 EFO64814.1 - 0.039 13.9 0.0 0.099 12.5 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF4407 PF14362.6 EFO64814.1 - 0.047 13.0 1.9 0.099 12.0 1.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ADIP PF11559.8 EFO64814.1 - 0.063 13.4 5.7 0.18 11.9 5.7 1.8 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding GrpE PF01025.19 EFO64814.1 - 0.068 12.8 1.5 0.24 11.1 1.5 1.9 2 0 0 2 2 1 0 GrpE ABC_tran_CTD PF16326.5 EFO64814.1 - 0.079 13.2 6.5 0.29 11.4 6.5 2.0 1 0 0 1 1 1 0 ABC transporter C-terminal domain Exonuc_VII_L PF02601.15 EFO64814.1 - 0.12 12.0 4.1 0.22 11.1 4.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DASH_Spc19 PF08287.11 EFO64814.1 - 0.12 12.2 5.7 0.31 10.9 5.7 1.8 1 0 0 1 1 1 0 Spc19 HrpB7 PF09486.10 EFO64814.1 - 0.15 12.4 5.5 0.038 14.4 1.8 1.9 2 0 0 2 2 1 0 Bacterial type III secretion protein (HrpB7) Snapin_Pallidin PF14712.6 EFO64814.1 - 0.15 12.5 6.5 0.59 10.6 6.5 2.0 1 0 0 1 1 1 0 Snapin/Pallidin Spc24 PF08286.11 EFO64814.1 - 0.16 12.2 3.3 0.38 11.0 3.3 1.7 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DUF4140 PF13600.6 EFO64814.1 - 0.16 12.4 1.2 0.53 10.8 1.2 1.9 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DHR10 PF18595.1 EFO64814.1 - 0.28 11.3 11.2 0.096 12.7 8.2 1.8 2 0 0 2 2 1 0 Designed helical repeat protein 10 domain Fez1 PF06818.15 EFO64814.1 - 0.3 11.5 6.9 0.13 12.7 3.3 2.0 2 0 0 2 2 2 0 Fez1 Med9 PF07544.13 EFO64814.1 - 0.41 10.8 5.0 1.1 9.4 5.0 1.7 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF5082 PF16888.5 EFO64814.1 - 0.48 10.7 8.8 5.4 7.3 6.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) EMP24_GP25L PF01105.24 EFO64814.1 - 0.48 10.3 2.2 1.2 9.1 2.2 1.6 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Csm1_N PF18504.1 EFO64814.1 - 0.52 10.7 6.2 1.1 9.7 3.2 2.5 2 0 0 2 2 2 0 Csm1 N-terminal domain CLZ PF16526.5 EFO64814.1 - 0.61 10.5 5.3 1.8 8.9 5.3 1.9 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels CC2-LZ PF16516.5 EFO64814.1 - 1.2 9.5 8.3 19 5.7 4.4 2.7 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator ZapB PF06005.12 EFO64814.1 - 1.5 9.3 8.9 6.2 7.3 6.6 2.6 2 0 0 2 2 2 0 Cell division protein ZapB Cep57_CLD_2 PF14197.6 EFO64814.1 - 2.9 8.0 7.8 0.3 11.2 2.0 2.4 3 0 0 3 3 2 0 Centrosome localisation domain of PPC89 TMF_DNA_bd PF12329.8 EFO64814.1 - 3.9 7.5 9.9 1.2 9.2 3.2 3.2 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.15 EFO64814.1 - 4.1 7.2 7.6 30 4.5 7.8 2.5 2 1 0 2 2 1 0 Septum formation initiator vATP-synt_AC39 PF01992.16 EFO64815.1 - 7e-51 173.7 4.0 7.9e-51 173.5 4.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Bcl-2 PF00452.19 EFO64816.1 - 0.1 13.3 0.2 0.27 12.0 0.2 1.7 1 1 1 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family Hum_adeno_E3A PF05393.11 EFO64817.1 - 0.14 12.1 0.7 0.3 11.1 0.1 1.8 2 0 0 2 2 2 0 Human adenovirus early E3A glycoprotein TetR_C_8 PF14278.6 EFO64818.1 - 0.16 12.1 0.5 5.9 7.1 0.1 2.4 1 1 1 2 2 2 0 Transcriptional regulator C-terminal region UPF0086 PF01868.16 EFO64819.1 - 1.7e-14 53.5 0.0 3e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Lzipper-MIP1 PF14389.6 EFO64820.1 - 0.0032 17.7 10.5 0.18 12.1 0.1 3.3 3 0 0 3 3 3 2 Leucine-zipper of ternary complex factor MIP1 Fez1 PF06818.15 EFO64820.1 - 0.0033 17.9 15.9 0.0033 17.9 15.9 2.2 1 1 1 2 2 2 1 Fez1 GAS PF13851.6 EFO64820.1 - 0.0054 16.1 20.5 0.0054 16.1 20.5 2.8 2 2 1 3 3 3 1 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 EFO64820.1 - 0.0075 16.3 4.6 0.0075 16.3 4.6 2.8 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF812 PF05667.11 EFO64820.1 - 0.0083 15.1 24.9 0.01 14.8 24.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) IFT57 PF10498.9 EFO64820.1 - 0.017 14.1 21.2 0.025 13.5 21.2 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Nrf1_DNA-bind PF10491.9 EFO64820.1 - 0.026 14.2 2.9 0.042 13.5 2.9 1.3 1 0 0 1 1 1 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 NosL PF05573.12 EFO64820.1 - 0.1 13.0 0.1 0.22 11.9 0.1 1.5 1 0 0 1 1 1 0 NosL RFX5_DNA_bdg PF14621.6 EFO64820.1 - 0.25 11.1 3.0 0.21 11.3 1.0 1.7 1 1 1 2 2 2 0 RFX5 DNA-binding domain ApoC-I PF04691.12 EFO64820.1 - 0.25 11.3 4.9 0.93 9.5 0.5 2.9 2 1 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) DUF5644 PF18712.1 EFO64820.1 - 0.41 10.7 3.0 0.51 10.4 0.2 2.5 2 1 1 3 3 3 0 Family of unknown function (DUF5644) DUF2400 PF09674.10 EFO64820.1 - 0.49 10.4 10.7 0.36 10.8 4.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2400) DUF3479 PF11965.8 EFO64820.1 - 0.87 9.7 9.6 0.29 11.2 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3479) Peptidase_M15_2 PF05951.13 EFO64820.1 - 0.94 9.1 3.2 0.61 9.7 0.1 2.1 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF882) DUF724 PF05266.14 EFO64820.1 - 3.4 7.5 27.3 0.89 9.4 12.2 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Cytochrom_B562 PF07361.11 EFO64820.1 - 4.2 8.1 21.9 4.3 8.0 3.7 3.2 2 1 1 3 3 3 0 Cytochrome b562 Fib_alpha PF08702.10 EFO64820.1 - 4.3 7.5 24.9 15 5.8 13.0 2.8 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family SPATA24 PF15175.6 EFO64820.1 - 4.7 7.1 24.9 8.8 6.2 0.5 2.2 1 1 1 2 2 2 0 Spermatogenesis-associated protein 24 KIP1 PF07765.12 EFO64820.1 - 7.1 6.8 15.1 0.66 10.1 0.6 3.5 2 1 3 5 5 5 0 KIP1-like protein DUF3450 PF11932.8 EFO64820.1 - 7.2 5.8 31.8 4.3 6.6 15.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 EFO64820.1 - 8.7 6.4 20.8 2.5 8.1 7.5 3.3 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) zf-CHY PF05495.12 EFO64822.1 - 2.3e-07 31.2 20.3 2.3e-07 31.2 20.3 3.5 2 1 0 2 2 2 1 CHY zinc finger FHA PF00498.26 EFO64823.1 - 6e-14 52.1 0.0 1.5e-13 50.9 0.0 1.7 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EFO64823.1 - 1.8e-06 28.2 0.0 4.7e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Aminotran_1_2 PF00155.21 EFO64824.1 - 7.3e-13 48.4 0.0 3.6e-06 26.4 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class I and II Pkinase PF00069.25 EFO64825.1 - 0.0034 16.8 0.0 0.018 14.4 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain DUF3391 PF11871.8 EFO64825.1 - 0.16 12.5 2.0 0.33 11.5 2.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) TFIIA PF03153.13 EFO64825.1 - 3.4 7.6 19.1 0.24 11.3 14.0 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Ndc1_Nup PF09531.10 EFO64825.1 - 3.6 6.2 7.4 1.1 7.9 3.9 1.8 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Ank_2 PF12796.7 EFO64827.1 - 5.7e-76 251.2 24.6 1.4e-15 57.7 0.1 7.2 1 1 8 9 9 9 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64827.1 - 1.1e-38 130.8 17.7 7.1e-06 26.2 0.0 10.6 3 1 8 11 11 11 10 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64827.1 - 4.2e-37 126.0 15.4 2.6e-09 37.4 0.0 9.7 8 2 2 10 10 10 8 Ankyrin repeats (many copies) Ank PF00023.30 EFO64827.1 - 3.8e-33 112.5 15.1 0.00094 19.5 0.0 12.6 11 1 1 12 12 12 9 Ankyrin repeat Ank_3 PF13606.6 EFO64827.1 - 2e-28 95.3 15.7 0.011 16.2 0.0 13.0 13 0 0 13 13 13 7 Ankyrin repeat Pkinase PF00069.25 EFO64827.1 - 0.0022 17.4 1.5 0.0052 16.2 0.1 2.2 3 0 0 3 3 3 1 Protein kinase domain Mss4 PF04421.13 EFO64827.1 - 0.07 13.3 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Mss4 protein Pkinase_Tyr PF07714.17 EFO64827.1 - 0.1 11.9 0.0 0.36 10.1 0.0 1.9 1 0 0 1 1 1 0 Protein tyrosine kinase GIT_CC PF16559.5 EFO64829.1 - 0.032 14.1 7.2 1.8 8.5 4.6 3.0 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Macoilin PF09726.9 EFO64830.1 - 0.0015 17.2 3.9 0.0023 16.6 3.9 1.3 1 0 0 1 1 1 1 Macoilin family DHR10 PF18595.1 EFO64830.1 - 0.0022 18.1 11.1 0.43 10.6 4.5 2.7 2 1 0 2 2 2 2 Designed helical repeat protein 10 domain Tropomyosin_1 PF12718.7 EFO64830.1 - 0.0031 17.7 7.0 0.0076 16.4 7.0 1.7 1 0 0 1 1 1 1 Tropomyosin like DUF4407 PF14362.6 EFO64830.1 - 0.0033 16.8 1.7 0.0033 16.8 1.7 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4407) NBD94 PF16830.5 EFO64830.1 - 0.0034 17.7 1.7 0.0034 17.7 1.7 3.1 3 1 1 4 4 3 1 Nucleotide-Binding Domain 94 of RH DUF948 PF06103.11 EFO64830.1 - 0.014 15.7 5.1 0.016 15.5 2.0 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) BLOC1_2 PF10046.9 EFO64830.1 - 0.015 15.6 10.8 0.07 13.4 1.4 2.9 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RPW8 PF05659.11 EFO64830.1 - 0.031 14.0 0.9 0.097 12.4 0.3 2.2 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 ZapB PF06005.12 EFO64830.1 - 0.055 13.9 20.7 2.8 8.5 10.6 3.9 2 1 1 3 3 2 0 Cell division protein ZapB Spc29 PF17082.5 EFO64830.1 - 0.071 12.9 4.2 0.2 11.4 4.1 1.8 1 1 0 1 1 1 0 Spindle Pole Component 29 UPF0242 PF06785.11 EFO64830.1 - 0.089 12.9 12.1 0.025 14.7 8.9 1.8 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4515 PF14988.6 EFO64830.1 - 0.1 12.4 11.2 0.041 13.7 6.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4515) PHM7_cyt PF14703.6 EFO64830.1 - 0.11 12.8 3.5 6.1 7.0 3.5 2.3 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter DUF3450 PF11932.8 EFO64830.1 - 0.12 11.7 8.1 0.38 10.0 6.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) SCA7 PF08313.12 EFO64830.1 - 0.15 12.0 0.2 0.83 9.6 0.1 2.1 2 0 0 2 2 2 0 SCA7, zinc-binding domain DUF4200 PF13863.6 EFO64830.1 - 0.15 12.4 10.9 0.11 13.0 7.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) TMF_TATA_bd PF12325.8 EFO64830.1 - 0.22 11.8 14.2 0.11 12.7 2.5 3.5 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding DivIC PF04977.15 EFO64830.1 - 0.24 11.2 18.1 0.86 9.4 2.5 3.7 2 1 2 4 4 3 0 Septum formation initiator UPF0184 PF03670.13 EFO64830.1 - 0.27 11.7 7.3 4.1 7.9 1.7 2.9 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0184) PspA_IM30 PF04012.12 EFO64830.1 - 0.41 10.2 7.0 0.95 9.0 6.8 1.8 1 1 0 1 1 1 0 PspA/IM30 family PRKG1_interact PF15898.5 EFO64830.1 - 0.41 11.6 9.4 4.9 8.1 6.7 2.8 2 1 1 3 3 2 0 cGMP-dependent protein kinase interacting domain KLRAQ PF10205.9 EFO64830.1 - 0.71 10.1 8.8 12 6.2 8.7 2.6 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein DUF2203 PF09969.9 EFO64830.1 - 0.78 10.5 5.7 0.58 10.9 1.2 2.5 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF4763 PF15960.5 EFO64830.1 - 0.92 8.8 12.0 1.9 7.7 4.1 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) Spc7 PF08317.11 EFO64830.1 - 0.95 8.3 11.1 0.43 9.4 4.5 2.2 1 1 2 3 3 3 0 Spc7 kinetochore protein bZIP_2 PF07716.15 EFO64830.1 - 0.97 9.6 12.3 2.6 8.2 1.4 3.4 2 1 0 3 3 3 0 Basic region leucine zipper Laminin_II PF06009.12 EFO64830.1 - 1 9.3 8.4 0.58 10.2 3.0 2.3 1 1 1 2 2 2 0 Laminin Domain II CENP-F_leu_zip PF10473.9 EFO64830.1 - 1.5 8.9 14.3 1.6 8.8 5.0 2.7 2 1 1 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FapA PF03961.13 EFO64830.1 - 1.8 7.1 8.3 0.75 8.3 4.4 1.8 1 1 1 2 2 2 0 Flagellar Assembly Protein A YscO PF07321.12 EFO64830.1 - 2.2 8.2 9.7 9.7 6.1 1.8 2.6 1 1 1 2 2 2 0 Type III secretion protein YscO Death PF00531.22 EFO64830.1 - 2.3 8.4 5.9 2.2 8.5 0.3 3.0 3 1 1 4 4 2 0 Death domain DUF4140 PF13600.6 EFO64830.1 - 2.4 8.6 5.0 9.7 6.7 0.2 3.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) TPR_MLP1_2 PF07926.12 EFO64830.1 - 2.6 8.1 12.7 4.1 7.5 3.5 2.5 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein HalX PF08663.10 EFO64830.1 - 2.7 8.4 5.1 23 5.4 0.2 3.3 3 0 0 3 3 3 0 HalX domain THOC7 PF05615.13 EFO64830.1 - 3 8.1 8.8 3.3 8.0 4.8 2.6 1 1 1 2 2 2 0 Tho complex subunit 7 DUF1664 PF07889.12 EFO64830.1 - 3.7 7.6 6.5 20 5.3 4.7 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 EFO64830.1 - 3.8 8.0 15.4 0.63 10.6 5.9 3.0 2 1 1 3 3 3 0 Apg6 coiled-coil region Spc24 PF08286.11 EFO64830.1 - 3.9 7.8 12.4 11 6.3 4.9 3.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 FlaC_arch PF05377.11 EFO64830.1 - 4 7.9 10.8 15 6.0 1.2 3.7 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) ADIP PF11559.8 EFO64830.1 - 4.1 7.5 16.8 0.42 10.7 5.9 2.8 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding NPV_P10 PF05531.12 EFO64830.1 - 4.8 7.7 9.7 0.79 10.2 1.2 3.2 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein TMPIT PF07851.13 EFO64830.1 - 6.8 5.8 8.1 0.95 8.7 2.5 1.8 1 1 2 3 3 3 0 TMPIT-like protein Fib_alpha PF08702.10 EFO64830.1 - 7.8 6.7 10.6 10 6.3 4.5 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Seryl_tRNA_N PF02403.22 EFO64830.1 - 8.3 6.7 10.5 1.5 9.1 3.3 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain KELK PF15796.5 EFO64830.1 - 8.6 6.9 12.1 0.18 12.3 3.9 2.3 3 0 0 3 3 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase SlyX PF04102.12 EFO64830.1 - 9.9 6.9 13.8 17 6.1 2.9 4.0 1 1 1 3 3 3 0 SlyX UDPGP PF01704.18 EFO64831.1 - 7.4e-22 77.6 0.0 4.6e-21 74.9 0.0 1.8 2 0 0 2 2 2 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 EFO64831.1 - 0.01 16.2 0.0 0.025 14.9 0.0 1.7 1 1 0 1 1 1 1 MobA-like NTP transferase domain HpaB PF03241.13 EFO64831.1 - 0.041 13.0 0.0 0.069 12.2 0.0 1.3 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase C terminal NTP_transferase PF00483.23 EFO64831.1 - 0.11 12.1 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Nucleotidyl transferase Gar1 PF04410.14 EFO64832.1 - 8.7e-19 67.8 0.0 9.8e-19 67.6 0.0 1.1 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Kelch_1 PF01344.25 EFO64833.1 - 2.6e-20 71.7 1.6 9.2e-06 25.2 0.1 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EFO64833.1 - 6.2e-18 64.4 5.6 1.5e-05 25.1 0.0 6.2 2 1 4 6 6 6 4 Kelch motif Kelch_4 PF13418.6 EFO64833.1 - 7.2e-14 51.5 9.8 9.5e-05 22.3 0.0 5.7 5 2 1 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EFO64833.1 - 4.1e-11 42.6 5.6 0.0016 18.4 0.0 6.0 5 1 1 6 6 6 4 Kelch motif Kelch_3 PF13415.6 EFO64833.1 - 3.5e-08 33.6 8.5 0.014 15.7 0.0 6.4 6 1 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EFO64833.1 - 1.7e-06 27.7 4.0 2.2 8.4 0.0 5.1 5 0 0 5 5 5 2 Kelch motif RWD PF05773.22 EFO64834.1 - 3.3e-08 33.8 0.2 7.6e-08 32.6 0.1 1.7 2 0 0 2 2 2 1 RWD domain CBF PF03914.17 EFO64835.1 - 2.9e-11 43.7 0.0 9.6e-11 42.0 0.0 1.9 1 0 0 1 1 1 1 CBF/Mak21 family DUF2768 PF10966.8 EFO64835.1 - 0.23 11.9 3.0 0.15 12.5 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2768) Imm5 PF14423.6 EFO64835.1 - 0.53 10.5 2.7 1.5 9.1 2.7 1.7 1 0 0 1 1 1 0 Immunity protein Imm5 DUF3472 PF11958.8 EFO64836.1 - 0.05 14.1 0.2 0.067 13.7 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3472) Ank_2 PF12796.7 EFO64837.1 - 3.4e-94 309.6 27.9 1.7e-15 57.3 0.1 6.2 1 1 8 9 9 9 9 Ankyrin repeats (3 copies) Ank PF00023.30 EFO64837.1 - 6.8e-41 137.0 6.2 0.00023 21.5 0.0 11.3 11 0 0 11 11 11 9 Ankyrin repeat Ank_3 PF13606.6 EFO64837.1 - 8.8e-38 124.0 6.8 0.016 15.7 0.1 11.7 11 0 0 11 11 11 9 Ankyrin repeat Ank_5 PF13857.6 EFO64837.1 - 1.6e-37 127.1 17.2 2e-07 31.1 0.1 11.2 1 1 10 11 11 11 10 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO64837.1 - 4e-34 116.5 6.7 5.3e-06 26.9 0.2 7.6 4 3 3 7 7 7 7 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO64837.1 - 4.1e-19 69.0 0.0 1.1e-18 67.6 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64837.1 - 7.9e-08 31.9 0.0 1.9e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase PQQ PF01011.21 EFO64838.1 - 0.00017 21.4 0.0 0.048 13.6 0.0 3.4 3 0 0 3 3 3 1 PQQ enzyme repeat PQQ_2 PF13360.6 EFO64838.1 - 0.0019 17.8 0.0 0.062 12.9 0.0 2.6 3 0 0 3 3 3 1 PQQ-like domain LRR_6 PF13516.6 EFO64839.1 - 2.2e-10 39.7 33.4 0.063 13.4 0.0 10.5 12 0 0 12 12 12 5 Leucine Rich repeat LRR_1 PF00560.33 EFO64839.1 - 0.0097 16.3 11.1 65 4.7 0.0 8.5 10 0 0 10 10 10 0 Leucine Rich Repeat LRR_4 PF12799.7 EFO64839.1 - 0.012 16.0 23.5 3.7 8.1 0.1 8.3 6 2 2 8 8 8 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO64839.1 - 0.028 14.2 15.9 6.9 6.5 0.1 7.1 6 2 1 7 7 7 0 Leucine rich repeat AAA PF00004.29 EFO64839.1 - 0.27 11.7 5.2 1.4 9.4 5.2 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF3843 PF12954.7 EFO64839.1 - 0.31 10.0 6.4 0.48 9.3 6.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3843) Tannase PF07519.11 EFO64839.1 - 0.63 8.9 1.9 0.97 8.3 1.9 1.2 1 0 0 1 1 1 0 Tannase and feruloyl esterase Cob_adeno_trans PF01923.18 EFO64839.1 - 2.6 8.2 8.6 1.5 9.0 2.4 2.6 1 1 0 2 2 2 0 Cobalamin adenosyltransferase DUF866 PF05907.13 EFO64840.1 - 1.6e-28 99.6 0.1 1.8e-28 99.4 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) zinc-ribbons_6 PF07191.12 EFO64840.1 - 0.2 11.7 3.5 0.66 10.0 3.5 1.9 1 1 0 1 1 1 0 zinc-ribbons TF_Zn_Ribbon PF08271.12 EFO64840.1 - 0.3 10.6 6.2 0.44 10.1 0.8 2.6 2 0 0 2 2 2 0 TFIIB zinc-binding PAPS_reduct PF01507.19 EFO64841.1 - 1.5e-17 64.2 0.0 2.5e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family ANAPC4_WD40 PF12894.7 EFO64842.1 - 1.7e-06 28.2 1.2 0.15 12.3 0.2 5.4 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain FYVE_2 PF02318.16 EFO64842.1 - 0.0027 17.9 1.1 0.0064 16.7 1.1 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger TPR_2 PF07719.17 EFO64842.1 - 0.049 13.8 0.8 14 6.1 0.2 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFO64844.1 - 1.7e-06 27.7 9.6 0.041 14.0 0.0 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFO64844.1 - 8.3e-05 22.8 20.5 0.00018 21.7 1.9 5.8 4 1 1 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFO64844.1 - 0.0065 16.7 0.4 0.0065 16.7 0.4 4.5 3 2 2 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EFO64844.1 - 0.33 11.6 7.2 42 4.9 0.3 4.9 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFO64844.1 - 0.36 10.7 0.1 0.36 10.7 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFO64844.1 - 0.46 10.2 4.4 38 4.1 0.0 3.9 4 0 0 4 4 4 0 TPR repeat TPR_6 PF13174.6 EFO64844.1 - 1.2 9.9 4.9 1e+02 3.9 0.6 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat GDE_N_bis PF14742.6 EFO64845.1 - 0.077 12.5 0.1 0.11 12.0 0.1 1.2 1 0 0 1 1 1 0 N-terminal domain of (some) glycogen debranching enzymes Ank_2 PF12796.7 EFO64846.1 - 2.9e-67 223.2 32.8 2e-12 47.5 0.2 9.5 2 2 11 13 13 13 12 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO64846.1 - 3e-34 118.6 0.0 8.5e-33 113.8 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Ank_5 PF13857.6 EFO64846.1 - 2.8e-31 107.2 21.3 7.4e-06 26.1 0.1 13.7 10 4 7 17 17 17 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64846.1 - 1.4e-29 98.9 12.9 0.029 14.9 0.0 14.1 14 0 0 14 14 14 9 Ankyrin repeat Ank PF00023.30 EFO64846.1 - 8.7e-27 92.4 11.5 0.0011 19.4 0.0 12.3 12 0 0 12 12 12 7 Ankyrin repeat Ank_4 PF13637.6 EFO64846.1 - 1.4e-25 89.3 17.4 0.00018 22.0 0.1 11.1 10 2 1 11 11 11 5 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO64846.1 - 3.8e-16 59.1 0.0 1.4e-15 57.3 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO64846.1 - 0.013 14.8 0.0 0.15 11.4 0.0 2.3 2 0 0 2 2 2 0 Kinase-like DUF948 PF06103.11 EFO64847.1 - 5.5 7.3 7.1 3.3 8.0 3.1 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) OB_NTP_bind PF07717.16 EFO64849.1 - 4.3e-13 49.4 0.0 1.1e-12 48.1 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFO64849.1 - 2.8e-12 46.9 0.0 9.5e-12 45.2 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.23 EFO64849.1 - 6.7e-10 39.2 0.0 1.6e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) AAA_30 PF13604.6 EFO64849.1 - 3.8e-06 26.8 0.0 6.4e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 EFO64849.1 - 6.2e-05 22.8 0.2 0.00016 21.5 0.2 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFO64849.1 - 0.0016 18.7 0.1 0.0061 16.8 0.0 2.0 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 EFO64849.1 - 0.0023 17.0 0.0 0.0049 16.0 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 EFO64849.1 - 0.025 14.9 0.0 0.055 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 EFO64849.1 - 0.039 13.9 0.0 0.41 10.6 0.0 2.5 4 0 0 4 4 4 0 Type III restriction enzyme, res subunit AAA_14 PF13173.6 EFO64849.1 - 0.042 13.9 0.0 0.42 10.7 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFO64849.1 - 0.16 11.7 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 EFO64850.1 - 6.9e-06 26.1 0.0 1.7e-05 24.8 0.0 1.6 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Ala_racemase_N PF01168.20 EFO64850.1 - 0.06 13.0 0.0 0.081 12.6 0.0 1.1 1 0 0 1 1 1 0 Alanine racemase, N-terminal domain V_ATPase_I PF01496.19 EFO64851.1 - 1.2e-204 681.8 4.3 5.5e-204 679.5 4.3 1.8 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family RNase_P_Rpp14 PF01900.19 EFO64852.1 - 0.018 15.3 0.1 0.025 14.8 0.1 1.2 1 0 0 1 1 1 0 Rpp14/Pop5 family Pkinase PF00069.25 EFO64854.1 - 1.1e-56 192.1 2.0 1.3e-33 116.5 0.0 3.2 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64854.1 - 2.8e-36 125.1 0.0 2.6e-24 85.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Ank_2 PF12796.7 EFO64854.1 - 6.8e-09 36.2 0.2 2.7e-08 34.3 0.2 2.0 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Kinase-like PF14531.6 EFO64854.1 - 3.3e-06 26.6 0.0 8.3e-06 25.3 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFO64854.1 - 0.0021 16.9 0.0 0.0049 15.7 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Ank_3 PF13606.6 EFO64854.1 - 0.0068 16.8 0.3 1.7 9.4 0.1 3.1 2 0 0 2 2 2 1 Ankyrin repeat Choline_kinase PF01633.20 EFO64854.1 - 0.021 14.4 0.0 7.4 6.1 0.0 2.5 2 0 0 2 2 2 0 Choline/ethanolamine kinase APH PF01636.23 EFO64854.1 - 0.025 14.5 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ank_5 PF13857.6 EFO64854.1 - 0.03 14.7 0.4 2.6 8.5 0.3 2.6 1 1 1 2 2 2 0 Ankyrin repeats (many copies) FAM76 PF16046.5 EFO64854.1 - 0.47 9.8 4.5 0.76 9.1 1.6 2.1 2 0 0 2 2 2 0 FAM76 protein TMF_DNA_bd PF12329.8 EFO64854.1 - 0.58 10.2 7.6 0.22 11.6 4.1 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Proteasome PF00227.26 EFO64857.1 - 2.6e-33 115.1 0.1 2.9e-33 115.0 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit PHD_like PF12910.7 EFO64858.1 - 0.1 12.6 0.1 0.13 12.3 0.1 1.1 1 0 0 1 1 1 0 Antitoxin of toxin-antitoxin, RelE / RelB, TA system Pyr_redox_2 PF07992.14 EFO64859.1 - 8.3e-50 169.7 4.8 9.4e-50 169.5 4.8 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFO64859.1 - 3.2e-23 82.5 2.2 2.2e-18 66.5 0.2 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFO64859.1 - 1.6e-17 63.9 4.1 5.3e-16 59.0 1.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EFO64859.1 - 1.1e-06 28.1 4.8 0.0031 16.7 0.5 3.4 2 2 1 3 3 3 3 Glucose inhibited division protein A K_oxygenase PF13434.6 EFO64859.1 - 9.3e-05 21.7 0.2 0.0079 15.4 0.0 2.4 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 EFO64859.1 - 0.00032 20.2 2.6 0.025 14.0 0.1 2.4 2 1 1 3 3 3 2 FAD dependent oxidoreductase HI0933_like PF03486.14 EFO64859.1 - 0.00081 18.2 4.5 0.07 11.8 0.6 2.9 2 2 1 3 3 3 2 HI0933-like protein NAD_binding_7 PF13241.6 EFO64859.1 - 0.0018 18.7 2.0 0.004 17.6 0.1 2.3 2 1 0 2 2 2 1 Putative NAD(P)-binding FAD_binding_2 PF00890.24 EFO64859.1 - 0.0031 16.7 6.5 0.0095 15.1 0.4 3.7 2 1 3 5 5 5 1 FAD binding domain Thi4 PF01946.17 EFO64859.1 - 0.0095 15.2 2.2 0.038 13.2 0.1 2.4 2 1 0 2 2 2 1 Thi4 family DAO PF01266.24 EFO64859.1 - 0.0098 15.5 9.1 0.11 12.1 0.0 3.5 3 1 1 4 4 4 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFO64859.1 - 0.021 15.0 0.3 0.082 13.2 0.0 2.2 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.20 EFO64859.1 - 0.058 13.4 1.2 0.24 11.5 0.4 2.4 2 1 1 3 3 3 0 Shikimate / quinate 5-dehydrogenase CDP-OH_P_transf PF01066.21 EFO64860.1 - 1.1e-12 48.5 1.1 1.1e-12 48.5 1.1 2.7 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase RIIa PF02197.17 EFO64861.1 - 0.001 18.7 0.1 0.015 14.9 0.0 2.3 2 0 0 2 2 2 1 Regulatory subunit of type II PKA R-subunit Exo_endo_phos PF03372.23 EFO64862.1 - 1e-09 38.2 0.0 1.9e-09 37.4 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EFO64862.1 - 0.011 15.6 0.1 0.029 14.2 0.1 1.7 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase Ist1 PF03398.14 EFO64863.1 - 0.018 14.9 0.8 0.21 11.5 0.2 2.2 1 1 1 2 2 2 0 Regulator of Vps4 activity in the MVB pathway Ribosomal_TL5_C PF14693.6 EFO64864.1 - 0.2 12.0 0.2 0.75 10.2 0.2 2.0 1 0 0 1 1 1 0 Ribosomal protein TL5, C-terminal domain TORC_M PF12885.7 EFO64864.1 - 0.23 11.4 3.1 0.31 11.0 0.4 2.6 2 0 0 2 2 2 0 Transducer of regulated CREB activity middle domain IFT20 PF14931.6 EFO64864.1 - 4.1 7.6 12.1 0.06 13.5 2.9 2.8 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 ABC_tran PF00005.27 EFO64865.1 - 1.4e-26 93.7 0.0 2.9e-26 92.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFO64865.1 - 2.6e-11 43.9 0.1 0.00015 21.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFO64865.1 - 4.1e-07 29.6 0.0 2.2e-06 27.3 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFO64865.1 - 2.8e-05 24.7 0.2 7e-05 23.4 0.2 1.6 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 EFO64865.1 - 0.00011 22.0 0.4 0.005 16.6 0.1 2.2 2 0 0 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 EFO64865.1 - 0.0014 18.6 0.0 0.0034 17.3 0.0 1.6 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EFO64865.1 - 0.0016 18.7 0.1 0.007 16.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFO64865.1 - 0.0046 16.7 0.0 0.013 15.2 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain Rad17 PF03215.15 EFO64865.1 - 0.005 16.8 0.0 0.0092 15.9 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain NB-ARC PF00931.22 EFO64865.1 - 0.012 14.8 0.0 0.022 13.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 EFO64865.1 - 0.034 14.1 0.0 0.067 13.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 EFO64865.1 - 0.052 13.3 0.0 0.13 11.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EFO64865.1 - 0.055 13.4 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase RNA_helicase PF00910.22 EFO64865.1 - 0.059 13.8 0.1 0.18 12.2 0.1 1.9 1 0 0 1 1 1 0 RNA helicase AAA_13 PF13166.6 EFO64865.1 - 0.081 11.6 0.0 3.3 6.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EFO64865.1 - 0.088 12.8 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EFO64865.1 - 0.099 13.1 0.1 0.25 11.7 0.1 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EFO64865.1 - 0.11 12.0 0.1 0.33 10.5 0.1 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 EFO64865.1 - 0.14 12.6 0.0 0.33 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain MCM PF00493.23 EFO64865.1 - 0.14 11.3 0.1 0.24 10.5 0.1 1.3 1 0 0 1 1 1 0 MCM P-loop domain AAA_18 PF13238.6 EFO64865.1 - 0.17 12.5 0.0 0.37 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF3341 PF11821.8 EFO64865.1 - 0.99 9.0 5.8 3.7 7.2 4.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3341) Ank_2 PF12796.7 EFO64866.1 - 3.4e-21 75.6 2.6 7.3e-10 39.3 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64866.1 - 4.5e-13 49.1 2.2 0.00036 20.7 0.1 4.6 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64866.1 - 1.1e-10 40.8 0.4 0.099 13.3 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EFO64866.1 - 5.1e-10 39.7 0.8 0.0037 17.8 0.0 4.7 2 2 4 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO64866.1 - 6e-09 35.9 0.9 0.014 15.8 0.1 5.4 4 1 0 4 4 4 2 Ankyrin repeat PAGK PF15284.6 EFO64866.1 - 0.085 12.8 0.4 5.3 7.0 0.0 3.4 4 0 0 4 4 4 0 Phage-encoded virulence factor zf-CCCH_2 PF14608.6 EFO64867.1 - 0.00045 20.6 1.7 0.00091 19.6 1.7 1.5 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger zf-CCCH PF00642.24 EFO64867.1 - 0.0005 19.9 0.5 0.001 18.9 0.5 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EFO64867.1 - 0.015 15.1 4.6 0.019 14.7 2.6 2.3 2 1 0 2 2 2 0 CCCH-type zinc finger HCV_NS5a_C PF12941.7 EFO64867.1 - 0.026 14.4 0.0 0.03 14.2 0.0 1.1 1 0 0 1 1 1 0 HCV NS5a protein C-terminal region zf_CCCH_4 PF18345.1 EFO64867.1 - 0.029 14.4 8.2 0.033 14.2 1.1 2.9 3 0 0 3 3 3 0 Zinc finger domain START PF01852.19 EFO64869.1 - 3.9e-10 39.5 0.0 6e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 START domain GILT PF03227.16 EFO64871.1 - 9.1e-05 22.7 0.0 0.00021 21.5 0.0 1.6 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) LRRNT_2 PF08263.12 EFO64871.1 - 0.01 16.2 0.3 0.019 15.3 0.3 1.5 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain HTH_32 PF13565.6 EFO64873.1 - 0.00022 21.8 3.2 0.0033 18.0 1.2 2.2 2 0 0 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.6 EFO64873.1 - 0.012 15.4 0.2 0.068 13.0 0.0 2.1 2 0 0 2 2 2 0 Homeodomain-like domain PAPS_reduct PF01507.19 EFO64874.1 - 9.2e-09 35.6 0.0 1.1e-05 25.5 0.0 2.2 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Cullin_binding PF03556.15 EFO64875.1 - 1.9e-08 34.8 0.2 3.6e-08 33.9 0.2 1.4 1 0 0 1 1 1 1 Cullin binding ArfGap PF01412.18 EFO64876.1 - 9.1e-31 106.4 0.0 1.1e-30 106.0 0.0 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Pkinase PF00069.25 EFO64877.1 - 3.1e-16 59.5 0.1 5.5e-11 42.3 0.1 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64877.1 - 6.6e-10 38.7 0.1 3.2e-07 29.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase GTP_EFTU_D3 PF03143.17 EFO64877.1 - 0.079 13.3 0.2 0.24 11.7 0.0 1.8 2 0 0 2 2 2 0 Elongation factor Tu C-terminal domain DEAD PF00270.29 EFO64878.1 - 1.8e-40 138.6 0.1 2.4e-40 138.1 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO64878.1 - 1.4e-24 86.6 0.2 6.4e-24 84.4 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain GerD PF17898.1 EFO64878.1 - 0.042 13.8 0.1 0.12 12.4 0.0 1.7 2 0 0 2 2 2 0 Spore germination GerD central core domain Metallophos PF00149.28 EFO64879.1 - 1e-11 45.7 0.4 4.2e-08 33.9 0.1 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFO64879.1 - 0.00011 22.4 0.0 0.001 19.3 0.0 2.2 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Kelch_5 PF13854.6 EFO64880.1 - 1.4e-28 98.3 11.9 3e-08 33.5 0.1 7.3 7 0 0 7 7 7 4 Kelch motif Kelch_4 PF13418.6 EFO64880.1 - 2.4e-25 88.3 5.6 8.7e-05 22.4 0.0 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 EFO64880.1 - 2.4e-18 65.9 14.3 1.3e-06 28.6 0.1 7.8 7 1 0 7 7 7 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EFO64880.1 - 2.5e-17 62.5 6.1 0.00025 21.2 0.2 5.8 4 1 1 5 5 5 4 Kelch motif Kelch_2 PF07646.15 EFO64880.1 - 1.7e-16 59.5 11.0 2.2e-05 24.3 0.1 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 EFO64880.1 - 2.3e-14 52.7 2.5 0.00041 19.9 0.1 5.3 5 0 0 5 5 5 3 Kelch motif Acyl_transf_1 PF00698.21 EFO64880.1 - 0.012 15.1 0.1 0.025 14.1 0.1 1.4 1 0 0 1 1 1 0 Acyl transferase domain AAA_11 PF13086.6 EFO64882.1 - 2.7e-18 66.7 1.0 3.3e-08 33.6 0.1 3.1 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 EFO64882.1 - 1.4e-08 34.7 0.0 4.2e-08 33.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain DUF2439 PF10382.9 EFO64882.1 - 4.9e-07 30.0 0.2 1.5e-06 28.4 0.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) AAA_19 PF13245.6 EFO64882.1 - 3.7e-05 24.1 0.0 0.0001 22.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain TFIIS_C PF01096.18 EFO64883.1 - 3.3e-16 58.8 5.2 3.3e-16 58.8 5.2 2.9 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EFO64883.1 - 8.3e-05 22.4 4.1 8.3e-05 22.4 4.1 2.3 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 EFO64883.1 - 0.0039 17.1 1.2 0.0039 17.1 1.2 2.3 2 1 0 2 2 2 1 Transposase zinc-ribbon domain DpnI PF06044.12 EFO64883.1 - 0.018 14.6 0.7 0.018 14.6 0.7 1.8 1 1 1 2 2 2 0 Dam-replacing family Cys_rich_CPCC PF14206.6 EFO64883.1 - 0.083 12.7 0.7 0.083 12.7 0.7 2.5 2 1 0 2 2 2 0 Cysteine-rich CPCC Baculo_LEF5_C PF11792.8 EFO64883.1 - 0.086 12.5 0.4 0.086 12.5 0.4 2.0 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain Lar_restr_allev PF14354.6 EFO64883.1 - 0.16 12.4 7.2 0.67 10.4 0.2 2.3 2 0 0 2 2 2 0 Restriction alleviation protein Lar Ldh_1_N PF00056.23 EFO64885.1 - 1.7e-30 105.9 0.0 2.7e-30 105.3 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EFO64885.1 - 7.1e-22 78.1 0.0 1.1e-21 77.5 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain SWIM PF04434.17 EFO64887.1 - 0.0015 18.1 1.4 0.15 11.8 0.1 2.4 2 0 0 2 2 2 2 SWIM zinc finger Diphthamide_syn PF01866.17 EFO64888.1 - 2.2e-56 191.5 0.0 2.6e-56 191.3 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Methyltransf_15 PF09445.10 EFO64889.1 - 1.3e-52 177.7 0.1 1.9e-52 177.2 0.1 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.15 EFO64889.1 - 0.0056 16.3 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Met_10 PF02475.16 EFO64889.1 - 0.059 13.1 0.0 0.081 12.7 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein DUF4927 PF16279.5 EFO64890.1 - 0.13 13.3 3.5 1.2 10.2 0.5 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4927) FlaC_arch PF05377.11 EFO64890.1 - 0.16 12.4 8.5 1.6 9.2 0.0 4.7 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) SlyX PF04102.12 EFO64890.1 - 0.42 11.3 0.0 0.42 11.3 0.0 6.0 3 1 3 7 7 7 0 SlyX ADIP PF11559.8 EFO64890.1 - 0.44 10.6 36.3 0.46 10.6 0.5 4.4 1 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding TPR_MLP1_2 PF07926.12 EFO64890.1 - 0.95 9.5 41.7 1.2 9.2 12.4 4.3 1 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein LPP PF04728.13 EFO64890.1 - 1.2 9.5 11.8 12 6.4 0.1 5.5 5 0 0 5 5 5 0 Lipoprotein leucine-zipper NPV_P10 PF05531.12 EFO64890.1 - 1.6 9.3 12.1 15 6.1 0.1 4.8 4 2 0 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF3584 PF12128.8 EFO64890.1 - 4.4 4.7 36.2 1.4 6.4 11.0 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF3584) INCENP_ARK-bind PF03941.15 EFO64892.1 - 0.0036 17.2 0.1 0.0036 17.2 0.1 2.5 3 0 0 3 3 3 1 Inner centromere protein, ARK binding region RBM39linker PF15519.6 EFO64892.1 - 0.12 13.4 0.3 0.12 13.4 0.3 3.3 2 1 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein HMMR_N PF15905.5 EFO64892.1 - 5.5 6.4 52.8 2.9e+02 0.7 51.6 2.8 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal ATP_bind_1 PF03029.17 EFO64893.1 - 1.5e-51 175.5 0.0 1.6e-51 175.4 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 EFO64893.1 - 0.0036 17.7 0.0 0.0081 16.5 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain CLP1_P PF16575.5 EFO64893.1 - 0.0062 16.3 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_22 PF13401.6 EFO64893.1 - 0.0078 16.5 0.0 0.031 14.5 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 EFO64893.1 - 0.0081 16.7 0.0 0.012 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFO64893.1 - 0.024 14.3 0.0 0.045 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EFO64893.1 - 0.058 13.8 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.12 EFO64893.1 - 0.062 12.6 0.0 0.46 9.8 0.0 1.9 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Zeta_toxin PF06414.12 EFO64893.1 - 0.07 12.4 0.0 5.8 6.1 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin AAA_24 PF13479.6 EFO64893.1 - 0.084 12.6 0.0 0.28 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 EFO64893.1 - 0.13 12.0 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase RsgA_GTPase PF03193.16 EFO64893.1 - 0.18 11.7 0.1 6.6 6.6 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase RNA_helicase PF00910.22 EFO64893.1 - 0.19 12.1 0.0 0.36 11.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Sybindin PF04099.12 EFO64894.1 - 5.8e-12 45.7 0.0 8.5e-12 45.2 0.0 1.2 1 1 0 1 1 1 1 Sybindin-like family Uricase PF01014.18 EFO64895.1 - 0.25 11.6 1.4 0.58 10.4 0.8 2.0 2 0 0 2 2 2 0 Uricase Cornichon PF03311.14 EFO64897.1 - 1.9e-06 28.2 10.1 2.3e-06 27.9 10.1 1.1 1 0 0 1 1 1 1 Cornichon protein 7TM_GPCR_Srh PF10318.9 EFO64897.1 - 0.031 13.3 8.5 0.78 8.7 2.9 2.0 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srh DHHC PF01529.20 EFO64897.1 - 3.8 7.6 8.1 1.8 8.7 5.5 1.7 1 1 1 2 2 2 0 DHHC palmitoyltransferase TFIIS_C PF01096.18 EFO64898.1 - 4e-18 65.0 4.8 4e-18 65.0 4.8 2.6 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) PADR1 PF08063.12 EFO64898.1 - 0.084 12.7 0.1 0.084 12.7 0.1 3.1 3 1 0 3 3 3 0 PADR1 (NUC008) domain Cytochrom_C550 PF14495.6 EFO64898.1 - 0.16 11.7 0.2 0.16 11.7 0.2 1.9 1 1 1 2 2 2 0 Cytochrome c-550 domain DUF2387 PF09526.10 EFO64898.1 - 0.37 11.0 5.4 0.1 12.8 1.5 2.0 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) Auto_anti-p27 PF06677.12 EFO64898.1 - 1.1 9.5 11.2 5.7 7.2 2.5 2.7 2 1 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Ogr_Delta PF04606.12 EFO64898.1 - 1.7 8.7 10.6 0.45 10.5 6.6 2.1 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger DUF4379 PF14311.6 EFO64898.1 - 1.8 9.0 9.0 13 6.3 0.8 3.1 2 1 1 3 3 3 0 Probable Zinc-ribbon domain zf-met PF12874.7 EFO64898.1 - 2 8.9 10.0 4.3 7.9 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger of C2H2 type DZR PF12773.7 EFO64898.1 - 4.7 7.3 18.8 0.42 10.7 2.8 2.9 1 1 1 2 2 2 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 EFO64898.1 - 8.4 6.6 19.4 4.3 7.5 0.1 4.1 3 1 1 4 4 4 0 Zinc ribbon domain Aa_trans PF01490.18 EFO64900.1 - 5.4e-30 104.4 41.8 1.9e-16 59.8 16.8 2.4 3 0 0 3 3 3 2 Transmembrane amino acid transporter protein DJ-1_PfpI PF01965.24 EFO64900.1 - 0.0023 17.8 0.0 0.0041 16.9 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family Halogen_Hydrol PF10112.9 EFO64900.1 - 0.34 10.9 0.0 0.34 10.9 0.0 3.3 4 0 0 4 4 4 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein AAA PF00004.29 EFO64901.1 - 2.9e-28 98.9 0.0 5.2e-28 98.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFO64901.1 - 0.00019 21.8 0.1 0.00058 20.3 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain Viral_helicase1 PF01443.18 EFO64901.1 - 0.00019 21.2 0.0 0.00045 20.0 0.0 1.6 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase RuvB_N PF05496.12 EFO64901.1 - 0.0018 18.0 0.1 0.0048 16.7 0.1 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFO64901.1 - 0.0062 16.8 0.1 0.057 13.7 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFO64901.1 - 0.012 15.7 0.0 0.027 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EFO64901.1 - 0.02 14.4 0.1 2.5 7.6 0.0 2.9 2 1 1 3 3 3 0 AAA domain AAA_18 PF13238.6 EFO64901.1 - 0.074 13.6 0.0 0.22 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 EFO64901.1 - 0.11 12.5 0.0 0.23 11.4 0.0 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_2 PF07724.14 EFO64901.1 - 0.12 12.5 0.0 0.36 10.9 0.0 1.8 1 1 1 2 2 2 0 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 EFO64901.1 - 0.12 12.7 0.0 1.3 9.4 0.0 2.4 2 0 0 2 2 2 0 RNA helicase TIP49 PF06068.13 EFO64901.1 - 0.16 11.2 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain vATP-synt_E PF01991.18 EFO64903.1 - 4.4e-17 62.2 2.9 7.2e-17 61.5 2.9 1.3 1 1 0 1 1 1 1 ATP synthase (E/31 kDa) subunit NHL PF01436.21 EFO64904.1 - 1.7 8.8 4.3 10 6.4 0.0 3.5 4 0 0 4 4 4 0 NHL repeat Prok-RING_4 PF14447.6 EFO64905.1 - 0.0032 17.3 3.2 0.011 15.5 3.2 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Apolipoprotein PF01442.18 EFO64905.1 - 0.0034 17.3 2.1 0.0069 16.3 2.1 1.5 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain SF1-HH PF16275.5 EFO64905.1 - 0.26 11.6 1.8 0.76 10.1 0.1 2.6 2 0 0 2 2 2 0 Splicing factor 1 helix-hairpin domain DUF4094 PF13334.6 EFO64905.1 - 0.35 11.3 4.2 7 7.1 0.1 3.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4094) zf-RING_5 PF14634.6 EFO64905.1 - 0.88 9.6 6.8 2.2 8.3 6.8 1.7 1 0 0 1 1 1 0 zinc-RING finger domain DUF1664 PF07889.12 EFO64905.1 - 3.3 7.8 5.8 12 6.0 1.3 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.11 EFO64905.1 - 5.3 7.7 10.3 13 6.4 0.0 4.2 3 1 0 3 3 3 0 Syntaxin 6, N-terminal SDH_alpha PF03313.15 EFO64906.1 - 2.3e-57 194.7 0.4 3.4e-56 190.8 0.5 2.0 1 1 0 1 1 1 1 Serine dehydratase alpha chain SDH_beta PF03315.15 EFO64906.1 - 9.9e-22 78.0 0.0 5.3e-13 49.6 0.1 2.6 1 1 1 2 2 2 2 Serine dehydratase beta chain CPSF_A PF03178.15 EFO64908.1 - 6e-11 42.2 0.1 1.4e-10 41.0 0.1 1.5 1 0 0 1 1 1 1 CPSF A subunit region FAE1_CUT1_RppA PF08392.12 EFO64908.1 - 0.055 12.8 0.1 0.1 11.9 0.1 1.3 1 0 0 1 1 1 0 FAE1/Type III polyketide synthase-like protein ParA PF10609.9 EFO64909.1 - 4e-81 272.1 0.6 5.1e-81 271.7 0.6 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EFO64909.1 - 1.1e-13 51.4 0.0 4.8e-12 46.1 0.0 2.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EFO64909.1 - 4.3e-07 30.0 1.0 3.8e-06 26.9 0.8 2.4 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EFO64909.1 - 9.9e-07 28.2 2.6 2.8e-05 23.5 0.1 2.6 2 1 1 3 3 3 1 Anion-transporting ATPase AAA_26 PF13500.6 EFO64909.1 - 0.001 18.9 0.1 0.0091 15.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EFO64909.1 - 0.0057 15.9 0.1 0.0096 15.1 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain Fer4_NifH PF00142.18 EFO64909.1 - 0.012 15.1 0.3 0.32 10.4 0.1 2.2 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CLP1_P PF16575.5 EFO64909.1 - 0.025 14.4 0.1 0.36 10.6 0.0 2.2 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop RsgA_GTPase PF03193.16 EFO64909.1 - 0.1 12.5 0.9 0.18 11.7 0.2 1.7 2 0 0 2 2 2 0 RsgA GTPase MipZ PF09140.11 EFO64909.1 - 0.15 11.4 0.1 0.36 10.1 0.1 1.6 2 0 0 2 2 2 0 ATPase MipZ Sipho_Gp157 PF05565.11 EFO64910.1 - 0.33 10.9 2.3 5.9 6.9 0.1 2.3 2 0 0 2 2 2 0 Siphovirus Gp157 DZR PF12773.7 EFO64910.1 - 0.39 10.8 7.7 0.72 9.9 7.7 1.5 1 0 0 1 1 1 0 Double zinc ribbon PolC_DP2 PF03833.13 EFO64910.1 - 0.71 7.7 3.4 1.1 7.0 3.4 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Fib_alpha PF08702.10 EFO64910.1 - 0.98 9.6 8.4 0.57 10.4 1.6 2.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family ParA PF10609.9 EFO64911.1 - 6.8e-76 255.0 0.1 8.5e-76 254.6 0.1 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EFO64911.1 - 1.9e-11 44.1 0.0 5.6e-10 39.4 0.0 2.2 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EFO64911.1 - 1.2e-05 25.3 0.1 3.4e-05 23.8 0.1 1.8 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EFO64911.1 - 0.0021 17.3 0.8 0.0045 16.2 0.1 1.8 2 1 0 2 2 2 1 Anion-transporting ATPase AAA_25 PF13481.6 EFO64911.1 - 0.0026 17.3 0.0 0.0049 16.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EFO64911.1 - 0.0036 16.5 0.0 0.0054 15.9 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain MipZ PF09140.11 EFO64911.1 - 0.0059 15.9 0.0 0.012 14.9 0.0 1.5 2 0 0 2 2 2 1 ATPase MipZ AAA_26 PF13500.6 EFO64911.1 - 0.013 15.3 0.2 0.14 12.0 0.0 2.3 2 1 0 3 3 3 0 AAA domain AAA_16 PF13191.6 EFO64911.1 - 0.03 14.7 0.0 0.046 14.1 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain A2L_zn_ribbon PF08792.10 EFO64911.1 - 0.06 13.1 0.5 0.29 10.9 0.0 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain RsgA_GTPase PF03193.16 EFO64911.1 - 0.063 13.2 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase MeaB PF03308.16 EFO64911.1 - 0.15 11.0 0.1 0.23 10.4 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 EFO64911.1 - 0.2 11.6 0.4 0.36 10.7 0.4 1.4 1 0 0 1 1 1 0 NACHT domain RhlB PF12300.8 EFO64911.1 - 0.43 10.7 2.7 0.88 9.7 2.7 1.5 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB Ank_2 PF12796.7 EFO64912.1 - 2.5e-41 140.1 2.2 1.9e-12 47.6 0.2 3.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO64912.1 - 1.9e-24 86.5 0.2 4e-24 85.4 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 EFO64912.1 - 2e-22 79.3 0.6 1.4e-06 28.7 0.1 4.9 3 1 0 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO64912.1 - 3.1e-20 71.7 4.0 4.9e-05 23.6 0.0 6.9 6 1 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EFO64912.1 - 6.1e-20 71.0 1.4 8.1e-06 26.0 0.1 5.5 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO64912.1 - 3.6e-18 65.8 0.1 7.6e-18 64.7 0.1 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Ank_3 PF13606.6 EFO64912.1 - 2.3e-14 52.1 0.6 0.0021 18.4 0.0 6.6 6 0 0 6 6 6 3 Ankyrin repeat HTH_52 PF18576.1 EFO64912.1 - 0.21 11.8 2.1 2.7 8.3 0.0 3.1 2 1 1 3 3 3 0 Helix-turn-helix domain Pepdidase_M14_N PF18027.1 EFO64913.1 - 2.7e-09 37.3 0.0 7.1e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain Peptidase_M14 PF00246.24 EFO64913.1 - 9.3e-06 25.6 0.1 0.19 11.5 0.0 2.7 2 0 0 2 2 2 2 Zinc carboxypeptidase Tox-PLDMTX PF15645.6 EFO64913.1 - 0.28 11.5 1.4 6.3 7.1 0.0 2.5 2 0 0 2 2 2 0 Dermonecrotoxin of the Papain-like fold TMF_DNA_bd PF12329.8 EFO64915.1 - 0.0099 15.9 1.6 0.0099 15.9 1.6 2.8 1 1 2 3 3 3 1 TATA element modulatory factor 1 DNA binding GAS PF13851.6 EFO64915.1 - 0.079 12.3 8.0 0.21 10.9 8.0 1.7 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Cep57_CLD_2 PF14197.6 EFO64915.1 - 0.08 13.0 4.8 0.5 10.5 0.6 2.7 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Phage_GP20 PF06810.11 EFO64915.1 - 0.13 12.1 4.4 1.8 8.3 1.1 2.2 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF4200 PF13863.6 EFO64915.1 - 0.46 10.9 5.6 0.29 11.6 1.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF1664 PF07889.12 EFO64915.1 - 0.54 10.3 5.1 0.91 9.6 0.8 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF3450 PF11932.8 EFO64915.1 - 0.84 8.9 6.6 6.5 6.0 6.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Cnn_1N PF07989.11 EFO64915.1 - 0.9 9.7 6.4 1.2 9.4 3.8 2.3 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 DUF724 PF05266.14 EFO64915.1 - 1.5 8.6 5.3 1.3 8.8 2.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DHR10 PF18595.1 EFO64915.1 - 8 6.6 10.8 2.2 8.4 0.8 2.8 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain P4Ha_N PF08336.11 EFO64916.1 - 0.023 14.7 0.2 0.041 13.9 0.2 1.4 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Terminase_5 PF06056.12 EFO64916.1 - 0.15 12.0 1.2 0.31 11.0 1.2 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Myb_DNA-bind_6 PF13921.6 EFO64916.1 - 0.16 12.3 0.7 0.55 10.5 0.3 2.0 2 0 0 2 2 2 0 Myb-like DNA-binding domain GST_N PF02798.20 EFO64917.1 - 0.004 17.5 0.0 0.016 15.5 0.0 2.0 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFO64917.1 - 0.0065 16.9 0.0 0.015 15.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain FNIP_C PF14638.6 EFO64917.1 - 0.15 11.6 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 Folliculin-interacting protein C-terminus Radial_spoke_3 PF06098.11 EFO64921.1 - 2.9e-80 269.6 0.1 3.3e-80 269.4 0.1 1.0 1 0 0 1 1 1 1 Radial spoke protein 3 Macoilin PF09726.9 EFO64921.1 - 3.9 5.9 8.5 5 5.6 8.5 1.1 1 0 0 1 1 1 0 Macoilin family Baculo_PEP_C PF04513.12 EFO64923.1 - 0.016 15.3 11.7 0.78 9.8 0.4 4.6 3 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.18 EFO64923.1 - 0.16 11.9 10.7 1.9 8.3 0.9 3.4 4 0 0 4 4 4 0 Apolipoprotein A1/A4/E domain CorA PF01544.18 EFO64923.1 - 0.27 10.5 10.6 2.3 7.5 0.1 4.0 2 1 1 4 4 4 0 CorA-like Mg2+ transporter protein SAM_KSR1 PF13543.6 EFO64923.1 - 3.9 7.6 12.4 22 5.2 0.2 4.4 4 1 1 5 5 5 0 SAM like domain present in kinase suppressor RAS 1 ATP-synt_F PF01990.17 EFO64924.1 - 1.2e-13 51.1 0.0 1.5e-13 50.9 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit Rhomboid PF01694.22 EFO64925.1 - 0.0015 18.5 6.4 0.0015 18.5 6.4 2.0 1 1 1 2 2 2 1 Rhomboid family DUF1751 PF08551.10 EFO64925.1 - 0.015 15.9 2.5 0.015 15.9 2.5 2.5 3 0 0 3 3 3 0 Eukaryotic integral membrane protein (DUF1751) TK PF00265.18 EFO64926.1 - 5.1e-44 150.2 0.0 5.8e-43 146.8 0.0 2.0 2 0 0 2 2 2 1 Thymidine kinase HEAT PF02985.22 EFO64927.1 - 0.00069 19.7 0.7 0.52 10.7 0.0 3.4 3 0 0 3 3 3 2 HEAT repeat WD40 PF00400.32 EFO64928.1 - 2e-22 79.0 4.6 1.2e-05 25.9 0.0 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat Sof1 PF04158.14 EFO64928.1 - 2.2e-14 53.5 4.9 2.2e-14 53.5 4.9 1.6 2 0 0 2 2 2 1 Sof1-like domain ANAPC4_WD40 PF12894.7 EFO64928.1 - 1.1e-12 48.1 0.0 0.098 13.0 0.0 5.9 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFO64928.1 - 5.1e-06 25.7 0.0 0.014 14.4 0.0 3.2 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EFO64928.1 - 0.012 15.0 0.0 32 3.7 0.0 3.7 4 0 0 4 4 4 0 WD40-like domain Cyclin_N PF00134.23 EFO64930.1 - 0.0014 18.4 0.3 0.002 17.9 0.3 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain TGF_beta_GS PF08515.12 EFO64932.1 - 0.093 12.2 1.5 0.2 11.2 1.5 1.5 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif SF1-HH PF16275.5 EFO64933.1 - 0.041 14.2 0.0 0.25 11.7 0.0 2.4 2 0 0 2 2 2 0 Splicing factor 1 helix-hairpin domain DUF4370 PF14290.6 EFO64933.1 - 0.082 12.8 0.0 0.33 10.8 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4370) Osmo_CC PF08946.10 EFO64933.1 - 0.94 9.8 3.8 0.72 10.1 0.4 2.7 2 0 0 2 2 2 0 Osmosensory transporter coiled coil Pkinase PF00069.25 EFO64934.1 - 2.9e-61 207.2 0.1 3.4e-61 206.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64934.1 - 1.5e-41 142.4 0.1 2.1e-41 142.0 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO64934.1 - 1.4e-05 24.6 0.0 0.0001 21.7 0.0 2.2 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 EFO64934.1 - 8.1e-05 22.1 0.2 0.00018 21.0 0.2 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFO64934.1 - 0.001 19.0 0.0 0.11 12.4 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFO64934.1 - 0.004 16.1 0.1 0.0089 15.0 0.1 1.6 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFO64934.1 - 0.028 13.2 0.0 0.04 12.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Choline_kinase PF01633.20 EFO64934.1 - 0.051 13.2 0.5 0.39 10.3 0.5 1.9 1 1 1 2 2 2 0 Choline/ethanolamine kinase EGF PF00008.27 EFO64935.1 - 0.37 11.1 24.1 0.21 11.9 1.4 3.5 3 1 1 4 4 4 0 EGF-like domain EB PF01683.18 EFO64935.1 - 4.4 7.7 28.5 8.9 6.7 5.1 2.8 1 1 1 2 2 2 0 EB module Ank_2 PF12796.7 EFO64936.1 - 1.2e-73 243.7 3.9 1.1e-16 61.2 0.1 4.7 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64936.1 - 5.8e-43 144.7 2.0 3.8e-09 36.9 0.1 7.6 7 1 0 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO64936.1 - 1.5e-37 126.4 1.5 0.00011 22.5 0.0 8.2 7 1 1 8 8 8 7 Ankyrin repeat Ank_3 PF13606.6 EFO64936.1 - 6e-32 106.1 0.9 0.0011 19.2 0.0 8.5 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 EFO64936.1 - 1.3e-30 105.0 8.9 0.00086 19.6 0.0 7.9 1 1 7 8 8 8 7 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO64936.1 - 1.5e-23 83.6 0.0 7e-23 81.3 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64936.1 - 3.8e-18 65.7 0.0 6.5e-18 65.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase T3SSipB PF16535.5 EFO64936.1 - 3.5 8.1 5.7 6.1 7.3 5.7 1.3 1 0 0 1 1 1 0 Type III cell invasion protein SipB VSP PF03302.13 EFO64937.1 - 2.5e-65 220.9 173.8 4.5e-61 206.9 95.9 4.3 1 1 1 3 3 3 2 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO64937.1 - 2.8e-05 24.2 18.3 2.8e-05 24.2 18.3 12.6 2 2 10 13 13 13 4 Furin-like repeat, cysteine-rich VSP PF03302.13 EFO64938.1 - 1.8e-37 129.2 97.5 3.4e-18 65.7 33.7 3.6 1 1 2 3 3 3 3 Giardia variant-specific surface protein cEGF PF12662.7 EFO64938.1 - 0.016 15.1 1.3 0.016 15.1 1.3 6.1 4 2 0 4 4 4 0 Complement Clr-like EGF-like stn_TNFRSF12A PF12191.8 EFO64938.1 - 3.4 7.9 7.2 60 3.9 3.2 3.8 2 1 1 3 3 3 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain TTL PF03133.15 EFO64939.1 - 6.7e-64 215.8 0.0 1.1e-45 156.0 0.0 2.2 2 0 0 2 2 2 2 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EFO64939.1 - 8.1e-06 25.3 0.0 0.0034 16.7 0.0 2.9 2 1 1 3 3 3 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EFO64939.1 - 0.00076 18.8 0.0 0.051 12.8 0.0 2.2 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp RimK PF08443.11 EFO64939.1 - 0.0028 17.3 0.0 0.059 13.0 0.0 2.4 2 0 0 2 2 2 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 EFO64939.1 - 0.0055 16.8 0.0 3.3 7.7 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain GSH-S_ATP PF02955.16 EFO64939.1 - 0.057 12.8 0.0 1.7 8.0 0.1 2.6 2 0 0 2 2 2 0 Prokaryotic glutathione synthetase, ATP-grasp domain DDHD PF02862.17 EFO64939.1 - 0.077 13.1 2.0 0.39 10.8 0.8 2.1 2 0 0 2 2 2 0 DDHD domain Bystin PF05291.11 EFO64940.1 - 5.1e-74 249.2 0.5 7.6e-74 248.6 0.5 1.2 1 0 0 1 1 1 1 Bystin Syja_N PF02383.18 EFO64941.1 - 1.8e-38 132.6 0.0 9.2e-38 130.3 0.0 2.0 1 1 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 EFO64941.1 - 0.00089 18.8 0.0 0.011 15.3 0.0 2.1 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family INPP5B_PH PF16776.5 EFO64941.1 - 0.023 14.4 0.0 0.066 12.9 0.0 1.8 2 0 0 2 2 2 0 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain DUF2207 PF09972.9 EFO64941.1 - 0.78 8.4 3.1 1.2 7.9 3.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4131 PF13567.6 EFO64941.1 - 3 7.4 8.4 4.9 6.8 8.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Pkinase PF00069.25 EFO64942.1 - 7.2e-57 192.7 0.0 1.7e-35 122.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64942.1 - 9.6e-22 77.5 0.0 1.7e-15 57.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Sipho_Gp157 PF05565.11 EFO64943.1 - 0.03 14.3 1.1 0.11 12.5 1.1 1.9 1 0 0 1 1 1 0 Siphovirus Gp157 HSBP1 PF06825.12 EFO64943.1 - 0.61 10.0 3.8 0.46 10.4 1.0 2.4 2 0 0 2 2 2 0 Heat shock factor binding protein 1 bZIP_2 PF07716.15 EFO64943.1 - 1.3 9.1 7.6 0.26 11.4 0.4 3.1 2 1 1 3 3 3 0 Basic region leucine zipper TMF_TATA_bd PF12325.8 EFO64943.1 - 2.2 8.5 9.4 3.9 7.7 6.6 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Ephrin_rec_like PF07699.13 EFO64945.1 - 0.022 14.5 0.1 0.022 14.5 0.1 5.6 6 0 0 6 6 6 0 Putative ephrin-receptor like Pkinase PF00069.25 EFO64946.1 - 5.5e-11 42.3 0.0 1.4e-10 41.0 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64946.1 - 3.3e-05 23.3 0.0 8.2e-05 22.0 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3136 PF11334.8 EFO64946.1 - 0.12 12.2 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3136) Pil1 PF13805.6 EFO64946.1 - 0.34 10.4 2.2 0.58 9.6 2.2 1.3 1 0 0 1 1 1 0 Eisosome component PIL1 Ank_2 PF12796.7 EFO64948.1 - 4.9e-69 228.9 16.9 1.7e-11 44.5 0.1 8.9 4 2 5 9 9 9 9 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64948.1 - 4.1e-36 122.6 21.0 0.0016 18.7 0.1 13.1 6 5 9 15 15 15 10 Ankyrin repeats (many copies) Ank PF00023.30 EFO64948.1 - 2.7e-32 109.8 17.0 0.06 13.8 0.0 14.1 14 0 0 14 14 14 8 Ankyrin repeat Ank_4 PF13637.6 EFO64948.1 - 5e-30 103.5 14.9 0.00017 22.1 0.1 11.2 8 3 4 12 12 12 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64948.1 - 1.4e-29 98.8 12.1 0.8 10.5 0.0 16.0 17 0 0 17 17 17 9 Ankyrin repeat Herpes_U44 PF04533.13 EFO64948.1 - 0.024 14.3 0.0 0.069 12.8 0.0 1.7 1 0 0 1 1 1 0 Herpes virus U44 protein DUF5301 PF17225.3 EFO64948.1 - 1.1 9.7 3.5 3.8 8.0 3.5 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5300) MFS_1 PF07690.16 EFO64949.1 - 2.4e-25 89.2 46.5 2.4e-25 89.2 46.5 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily Gram_pos_anchor PF00746.21 EFO64949.1 - 0.84 9.6 2.7 27 4.8 0.3 3.0 2 0 0 2 2 2 0 LPXTG cell wall anchor motif LRR_9 PF14580.6 EFO64950.1 - 2.2e-06 27.3 0.1 2.9e-06 26.9 0.1 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EFO64950.1 - 1.8e-05 25.0 5.2 0.013 15.9 0.2 3.2 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO64950.1 - 0.012 15.3 5.7 0.95 9.3 3.1 3.1 1 1 1 2 2 2 0 Leucine rich repeat LRR_1 PF00560.33 EFO64950.1 - 0.92 10.3 3.8 36 5.5 0.6 3.8 3 2 0 3 3 3 0 Leucine Rich Repeat LRR_6 PF13516.6 EFO64950.1 - 7.3 6.9 8.5 1.5 9.1 0.1 3.5 4 0 0 4 4 4 0 Leucine Rich repeat Roc PF08477.13 EFO64951.1 - 0.00013 22.1 0.0 0.00021 21.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFO64951.1 - 0.0004 20.0 0.0 0.00059 19.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Ras PF00071.22 EFO64951.1 - 0.0048 16.5 0.0 0.0072 15.9 0.0 1.3 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EFO64951.1 - 0.038 13.5 0.0 0.057 12.9 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family DUF4498 PF14926.6 EFO64952.1 - 6.1e-53 179.7 0.0 6.9e-53 179.5 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4498) Ank_2 PF12796.7 EFO64955.1 - 1.2e-51 173.2 13.2 4e-15 56.2 0.6 6.1 1 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64955.1 - 2.3e-27 94.7 11.7 8.1e-06 26.0 0.0 8.6 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO64955.1 - 2.2e-26 91.1 15.6 0.0028 18.0 0.0 11.7 11 1 1 12 12 12 7 Ankyrin repeat Ank_3 PF13606.6 EFO64955.1 - 1.9e-24 83.0 11.7 0.062 13.9 0.0 11.8 12 0 0 12 12 12 7 Ankyrin repeat Ank_4 PF13637.6 EFO64955.1 - 4.9e-24 84.4 1.1 8.7e-07 29.4 0.0 7.3 2 2 4 7 7 7 7 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO64955.1 - 9.8e-17 61.2 0.0 1.9e-16 60.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64955.1 - 3.2e-11 43.0 0.2 5.2e-11 42.3 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Sec7 PF01369.20 EFO64956.1 - 7.7e-06 25.7 0.1 3e-05 23.8 0.0 1.9 2 0 0 2 2 2 1 Sec7 domain SYCP2_ARLD PF18581.1 EFO64957.1 - 0.028 14.4 0.0 0.053 13.5 0.0 1.5 1 0 0 1 1 1 0 Synaptonemal complex 2 armadillo-repeat-like domain IPU_b_solenoid PF18783.1 EFO64957.1 - 0.1 12.6 0.4 0.21 11.6 0.4 1.5 1 0 0 1 1 1 0 Isopullulanase beta-solenoid repeat zf-C2H2_jaz PF12171.8 EFO64958.1 - 2e-08 34.3 0.2 3.1e-08 33.7 0.2 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFO64958.1 - 0.029 14.8 0.2 0.044 14.2 0.2 1.3 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EFO64958.1 - 0.079 13.3 0.1 0.11 12.9 0.1 1.4 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) PHP PF02811.19 EFO64959.1 - 3.2e-05 24.3 0.1 5.1e-05 23.6 0.1 1.6 1 1 0 1 1 1 1 PHP domain AP_endonuc_2 PF01261.24 EFO64959.1 - 0.08 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel LisH PF08513.11 EFO64959.1 - 0.1 12.6 0.2 0.51 10.4 0.0 2.2 2 0 0 2 2 2 0 LisH Ank_2 PF12796.7 EFO64960.1 - 9.1e-58 192.8 13.8 1.6e-12 47.8 0.0 7.1 2 2 6 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64960.1 - 4.4e-37 126.0 10.2 1e-06 29.1 0.0 8.9 6 3 3 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64960.1 - 3.3e-31 103.8 15.4 0.00028 21.1 0.0 12.4 12 1 1 13 13 13 7 Ankyrin repeat Ank_5 PF13857.6 EFO64960.1 - 4.3e-31 106.6 14.1 3.8e-05 23.9 0.1 8.9 5 2 4 9 9 9 8 Ankyrin repeats (many copies) Ank PF00023.30 EFO64960.1 - 8.2e-30 101.9 26.6 0.00086 19.7 0.0 12.3 11 2 1 12 12 12 8 Ankyrin repeat V-ATPase_C PF03223.15 EFO64963.1 - 4.7e-54 184.2 0.2 5.9e-54 183.9 0.2 1.1 1 0 0 1 1 1 1 V-ATPase subunit C AftA_C PF12249.8 EFO64963.1 - 0.018 14.7 0.1 0.03 14.0 0.1 1.3 1 0 0 1 1 1 0 Arabinofuranosyltransferase A C terminal Dopey_N PF04118.14 EFO64964.1 - 1.6e-15 57.0 2.7 1.6e-15 57.0 2.7 2.6 3 0 0 3 3 3 1 Dopey, N-terminal VSP PF03302.13 EFO64966.1 - 3.2e-179 595.9 664.8 6.4e-23 81.2 68.3 22.8 1 1 18 20 20 20 19 Giardia variant-specific surface protein AIP3 PF03915.13 EFO64968.1 - 0.079 12.0 0.6 0.11 11.6 0.6 1.3 1 0 0 1 1 1 0 Actin interacting protein 3 GlutR_dimer PF00745.20 EFO64968.1 - 0.14 12.6 1.3 0.34 11.4 0.7 1.9 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain Ank_2 PF12796.7 EFO64969.1 - 5.5e-83 273.6 23.6 3.7e-13 49.9 0.0 9.1 2 2 8 10 10 10 10 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO64969.1 - 1.4e-42 143.2 18.0 0.0001 22.5 0.1 14.3 7 4 8 15 15 15 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64969.1 - 5.3e-41 133.9 8.5 0.11 13.1 0.0 15.9 16 0 0 16 16 16 11 Ankyrin repeat Ank PF00023.30 EFO64969.1 - 3.1e-40 134.9 8.2 0.0025 18.2 0.0 15.3 16 1 0 16 16 16 9 Ankyrin repeat Ank_4 PF13637.6 EFO64969.1 - 1.5e-39 133.8 8.6 0.00058 20.4 0.1 12.4 8 5 5 13 13 13 10 Ankyrin repeats (many copies) Tup_N PF08581.10 EFO64970.1 - 0.012 15.9 4.1 1.1 9.6 0.0 3.8 3 1 0 3 3 3 0 Tup N-terminal VGPC1_C PF16799.5 EFO64970.1 - 0.044 13.8 0.2 17 5.5 0.1 3.2 2 0 0 2 2 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 DUF641 PF04859.12 EFO64970.1 - 0.19 12.1 10.0 0.63 10.4 1.0 4.3 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) DUF836 PF05768.14 EFO64970.1 - 0.27 11.7 2.8 0.75 10.2 0.1 2.9 3 0 0 3 3 3 0 Glutaredoxin-like domain (DUF836) zf-RING_4 PF14570.6 EFO64970.1 - 2 8.3 14.4 0.16 11.8 8.6 2.1 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_2 PF13923.6 EFO64970.1 - 3.7 7.5 17.7 13 5.7 17.7 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PKcGMP_CC PF16808.5 EFO64970.1 - 4.5 7.2 10.6 2.2 8.2 0.3 4.7 5 0 0 5 5 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase AA_kinase PF00696.28 EFO64971.1 - 1.4e-26 93.6 0.1 7.1e-26 91.3 0.1 1.8 1 1 0 1 1 1 1 Amino acid kinase family Kinesin PF00225.23 EFO64973.1 - 1.4e-116 389.1 0.3 1.4e-116 389.1 0.3 2.1 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFO64973.1 - 2e-31 109.0 2.0 2.2e-31 108.8 0.1 2.1 2 0 0 2 2 2 1 Microtubule binding Nsp1_C PF05064.13 EFO64973.1 - 0.038 13.8 21.7 0.15 11.8 8.8 3.7 3 0 0 3 3 3 0 Nsp1-like C-terminal region DUF4441 PF14536.6 EFO64973.1 - 2.2 8.5 8.7 3.9 7.7 7.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4441) zf-RING_UBOX PF13445.6 EFO64974.1 - 0.0044 17.0 3.2 0.0044 17.0 3.2 2.7 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFO64974.1 - 0.006 16.4 9.9 0.017 14.9 9.9 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFO64974.1 - 0.015 15.2 10.8 0.047 13.6 10.8 1.9 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 EFO64974.1 - 0.029 14.2 11.0 0.099 12.5 11.0 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFO64974.1 - 0.058 13.6 16.6 0.11 12.7 11.8 3.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 EFO64974.1 - 0.072 13.0 5.6 0.22 11.4 5.6 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 EFO64974.1 - 0.16 11.9 8.9 0.39 10.6 8.9 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EFO64974.1 - 0.18 12.1 8.7 0.31 11.4 5.7 2.5 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EFO64974.1 - 3.4 7.6 17.1 0.048 13.5 9.7 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TM2 PF05154.16 EFO64976.1 - 7.7e-20 71.0 11.8 1e-19 70.6 11.8 1.1 1 0 0 1 1 1 1 TM2 domain TPR_1 PF00515.28 EFO64977.1 - 5.1e-18 64.1 7.5 0.023 14.5 0.0 6.6 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFO64977.1 - 1.9e-16 58.7 5.8 0.0042 17.1 0.0 6.6 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.6 EFO64977.1 - 6.8e-15 54.3 1.3 0.06 13.8 0.0 6.9 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFO64977.1 - 1.4e-11 43.7 0.1 1.9 8.9 0.0 7.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFO64977.1 - 1.9e-11 44.3 0.0 0.015 15.8 0.0 5.4 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFO64977.1 - 5.7e-07 29.7 8.4 0.074 13.4 0.1 6.4 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFO64977.1 - 5.5e-06 26.9 0.1 3.5 8.3 0.0 5.1 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFO64977.1 - 1.7e-05 25.2 2.6 1.4 9.9 0.0 6.1 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFO64977.1 - 0.00025 20.6 3.2 6.8 6.5 0.0 5.3 4 1 1 5 5 5 1 TPR repeat TPR_9 PF13371.6 EFO64977.1 - 0.00035 20.7 0.0 2.5 8.3 0.0 4.3 3 1 1 4 4 4 1 Tetratricopeptide repeat Coatomer_E PF04733.14 EFO64977.1 - 0.0012 18.3 0.2 2.5 7.4 0.0 3.7 3 1 1 4 4 4 1 Coatomer epsilon subunit TPR_7 PF13176.6 EFO64977.1 - 0.0019 18.1 1.2 1.7e+02 2.6 0.0 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFO64977.1 - 0.045 14.4 0.0 1.1e+02 3.7 0.0 4.9 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_20 PF14561.6 EFO64977.1 - 0.1 12.9 0.0 31 5.0 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFO64977.1 - 5.1 7.4 11.5 8.4 6.7 0.3 4.5 5 1 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 PyrI_C PF02748.15 EFO64978.1 - 0.016 15.1 0.1 0.036 14.0 0.1 1.6 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain HypA PF01155.19 EFO64978.1 - 0.018 15.0 0.4 0.036 14.1 0.4 1.6 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 EFO64978.1 - 0.057 13.5 1.1 0.13 12.4 1.1 1.5 1 0 0 1 1 1 0 Zinc ribbon domain zf-C2H2 PF00096.26 EFO64978.1 - 0.4 11.2 3.9 0.86 10.2 0.5 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type Ank_2 PF12796.7 EFO64980.1 - 7.2e-62 206.0 1.0 1.4e-15 57.6 0.1 4.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO64980.1 - 3.9e-40 135.7 7.6 3.5e-11 43.4 0.6 7.0 5 2 3 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO64980.1 - 9.8e-38 127.0 1.1 0.00035 20.9 0.0 8.3 8 1 0 8 8 8 7 Ankyrin repeat Ank_5 PF13857.6 EFO64980.1 - 5.2e-37 125.4 8.0 1.9e-06 28.0 0.1 7.8 2 1 6 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO64980.1 - 6e-33 109.2 1.7 0.0061 17.0 0.0 8.8 9 0 0 9 9 9 7 Ankyrin repeat Pkinase PF00069.25 EFO64980.1 - 1.9e-23 83.2 0.0 5.6e-23 81.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64980.1 - 4.3e-19 68.8 0.0 6.7e-19 68.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SporV_AA PF12164.8 EFO64982.1 - 0.057 13.8 0.0 0.24 11.8 0.0 2.1 2 0 0 2 2 2 0 Stage V sporulation protein AA MFS_1 PF07690.16 EFO64983.1 - 5.5e-24 84.7 49.9 5.5e-24 84.7 49.9 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFO64983.1 - 1.7e-07 30.5 5.1 1.7e-07 30.5 5.1 4.3 2 1 2 4 4 4 2 Sugar (and other) transporter MFS_3 PF05977.13 EFO64983.1 - 0.21 9.9 11.8 0.022 13.1 3.0 2.2 2 0 0 2 2 2 0 Transmembrane secretion effector DUF131 PF01998.17 EFO64985.1 - 0.083 12.5 2.8 1.2 8.8 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function DUF131 VSP PF03302.13 EFO64986.1 - 1.5e-07 30.7 243.4 0.00012 21.1 20.1 9.7 1 1 6 8 8 8 5 Giardia variant-specific surface protein LRR_8 PF13855.6 EFO64987.1 - 6e-28 96.4 51.4 1.9e-09 37.1 1.8 8.7 5 2 3 9 9 9 7 Leucine rich repeat LRR_4 PF12799.7 EFO64987.1 - 5.5e-27 93.4 70.2 3.6e-08 33.6 1.4 11.2 6 3 5 12 12 12 10 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 EFO64987.1 - 0.00045 20.2 12.4 0.45 10.5 0.3 4.5 4 1 1 5 5 5 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EFO64987.1 - 0.0013 18.2 21.3 0.16 11.4 1.7 4.8 2 1 2 4 4 4 2 Leucine-rich repeat LRR_1 PF00560.33 EFO64987.1 - 0.2 12.3 53.7 7.1 7.6 0.1 13.4 13 3 1 14 14 14 0 Leucine Rich Repeat LRR_6 PF13516.6 EFO64987.1 - 0.55 10.4 42.6 0.34 11.1 0.1 12.7 14 0 0 14 14 14 0 Leucine Rich repeat Adaptin_N PF01602.20 EFO64988.1 - 1e-40 139.8 6.8 1e-40 139.8 6.8 1.4 2 0 0 2 2 2 1 Adaptin N terminal region HEAT_2 PF13646.6 EFO64988.1 - 0.0019 18.5 0.4 4.8 7.7 0.1 3.4 3 0 0 3 3 3 2 HEAT repeats HEAT PF02985.22 EFO64988.1 - 0.017 15.3 0.7 1.9 9.0 0.0 3.7 3 0 0 3 3 3 0 HEAT repeat Ssl1 PF04056.14 EFO64989.1 - 3.1e-07 30.4 0.0 6.7e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.6 EFO64989.1 - 0.0026 18.4 0.0 0.007 17.0 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain C1_2 PF03107.16 EFO64989.1 - 0.017 15.4 3.3 0.017 15.4 3.3 3.5 3 1 1 4 4 4 0 C1 domain Tfb4 PF03850.14 EFO64989.1 - 0.065 12.7 0.0 0.065 12.7 0.0 3.0 3 0 0 3 3 3 0 Transcription factor Tfb4 VWA PF00092.28 EFO64989.1 - 0.16 12.2 0.7 0.34 11.1 0.1 1.8 2 0 0 2 2 2 0 von Willebrand factor type A domain Fcf2 PF08698.11 EFO64991.1 - 1.3e-21 76.7 0.0 3.3e-21 75.5 0.0 1.6 1 1 1 2 2 2 1 Fcf2 pre-rRNA processing Tau95 PF09734.9 EFO64992.1 - 1.5e-10 42.0 0.4 4.8e-08 33.9 0.2 2.3 1 1 1 2 2 2 2 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Guanylate_cyc_2 PF09778.9 EFO64992.1 - 0.043 13.2 0.4 0.07 12.5 0.4 1.2 1 0 0 1 1 1 0 Guanylylate cyclase TSC22 PF01166.18 EFO64993.1 - 0.00048 20.4 1.7 0.0013 19.0 1.3 1.8 2 0 0 2 2 2 1 TSC-22/dip/bun family Shugoshin_N PF07558.11 EFO64993.1 - 0.013 15.3 3.5 0.013 15.3 3.5 1.8 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region WD40_alt PF14077.6 EFO64993.1 - 0.034 14.0 2.2 0.046 13.6 1.2 1.6 2 0 0 2 2 2 0 Alternative WD40 repeat motif bZIP_1 PF00170.21 EFO64993.1 - 0.12 12.5 1.0 0.32 11.1 1.0 1.7 1 0 0 1 1 1 0 bZIP transcription factor YabA PF06156.13 EFO64993.1 - 0.12 13.0 0.1 0.28 11.8 0.1 1.5 1 0 0 1 1 1 0 Initiation control protein YabA bZIP_2 PF07716.15 EFO64993.1 - 0.14 12.2 2.8 0.32 11.1 2.8 1.5 1 0 0 1 1 1 0 Basic region leucine zipper MMR_HSR1 PF01926.23 EFO64994.1 - 8.3e-07 29.1 0.1 4.1e-05 23.6 0.1 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EFO64994.1 - 1.4e-06 27.8 0.0 0.035 13.4 0.0 2.7 2 0 0 2 2 2 2 AIG1 family AAA_23 PF13476.6 EFO64994.1 - 1.5e-06 28.9 6.5 0.017 15.6 2.3 2.8 2 1 0 2 2 2 2 AAA domain Septin PF00735.18 EFO64994.1 - 5e-05 22.7 0.1 0.0006 19.2 0.1 2.2 1 1 0 1 1 1 1 Septin FtsK_SpoIIIE PF01580.18 EFO64994.1 - 0.0016 17.9 0.0 0.0037 16.6 0.0 1.6 1 0 0 1 1 1 1 FtsK/SpoIIIE family RsgA_GTPase PF03193.16 EFO64994.1 - 0.0075 16.2 0.4 0.055 13.4 0.4 2.2 1 1 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 EFO64994.1 - 0.011 15.4 0.0 0.026 14.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.20 EFO64994.1 - 0.014 14.6 3.1 0.043 13.0 0.0 2.3 2 1 0 2 2 2 0 G-protein alpha subunit DUF1972 PF09314.11 EFO64994.1 - 0.03 13.9 0.0 0.062 12.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1972) Vps5 PF09325.10 EFO64994.1 - 0.036 13.6 6.0 0.032 13.8 4.0 1.9 1 1 1 2 2 2 0 Vps5 C terminal like DUF87 PF01935.17 EFO64994.1 - 0.036 14.2 5.3 0.63 10.1 0.0 3.5 2 1 0 2 2 2 0 Helicase HerA, central domain AAA_24 PF13479.6 EFO64994.1 - 0.042 13.6 0.0 0.26 11.0 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 EFO64994.1 - 0.049 13.1 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Roc PF08477.13 EFO64994.1 - 0.049 13.8 0.0 0.2 11.9 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 EFO64994.1 - 0.062 13.7 0.0 0.25 11.8 0.0 2.1 2 0 0 2 2 1 0 RNA helicase TsaE PF02367.17 EFO64994.1 - 0.062 13.3 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EFO64994.1 - 0.071 13.6 0.3 0.68 10.5 0.0 2.6 2 1 0 2 2 2 0 ABC transporter GTP_EFTU PF00009.27 EFO64994.1 - 0.076 12.6 0.1 0.21 11.1 0.0 1.7 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain NACHT PF05729.12 EFO64994.1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 EFO64994.1 - 0.1 13.0 0.1 0.55 10.6 0.0 2.1 3 0 0 3 3 2 0 AAA ATPase domain FeoB_N PF02421.18 EFO64994.1 - 0.13 11.8 0.9 2.5 7.6 0.0 2.6 3 0 0 3 3 2 0 Ferrous iron transport protein B Terminase_4 PF05119.12 EFO64994.1 - 0.21 12.1 1.5 1.6 9.2 0.1 2.7 2 0 0 2 2 2 0 Phage terminase, small subunit APG6_N PF17675.1 EFO64994.1 - 0.26 11.8 8.5 8.3 6.9 0.0 3.4 3 1 0 3 3 3 0 Apg6 coiled-coil region E1-E2_ATPase PF00122.20 EFO64995.1 - 6.7e-24 84.4 0.7 7.9e-22 77.6 0.5 3.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFO64995.1 - 1.1e-10 42.1 0.0 0.0013 19.1 0.0 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFO64995.1 - 0.0013 18.4 0.0 0.0033 17.1 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EFO64995.1 - 0.0022 18.0 0.0 0.021 14.9 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) zf-RING_12 PF17976.1 EFO64995.1 - 0.016 15.5 1.1 0.032 14.5 1.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Hydrolase_3 PF08282.12 EFO64995.1 - 0.065 13.0 0.1 0.23 11.2 0.0 1.9 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Sa_NUDIX PF18167.1 EFO64996.1 - 0.075 12.8 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 SMODS-associated NUDIX domain PAP2 PF01569.21 EFO64997.1 - 2.3e-08 33.9 12.7 3.5e-08 33.3 7.5 2.5 2 1 0 2 2 2 1 PAP2 superfamily DUF212 PF02681.14 EFO64997.1 - 0.063 13.4 1.2 2.6 8.2 0.1 2.4 1 1 1 2 2 2 0 Divergent PAP2 family MFS_MOT1 PF16983.5 EFO64997.1 - 0.31 11.5 5.4 0.6 10.5 2.7 2.1 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily Fcf1 PF04900.12 EFO64998.1 - 1.2e-06 28.8 0.0 1.8e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Fcf1 PIN_6 PF17146.4 EFO64998.1 - 0.082 13.4 0.0 0.18 12.3 0.0 1.6 1 0 0 1 1 1 0 PIN domain of ribonuclease Pkinase PF00069.25 EFO64999.1 - 6.5e-15 55.2 0.0 1.3e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO64999.1 - 2.5e-07 30.3 0.0 6.6e-07 28.9 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO64999.1 - 3.1e-06 26.7 0.1 8.6e-06 25.3 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EFO64999.1 - 0.21 10.9 0.1 0.4 10.0 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Cpn60_TCP1 PF00118.24 EFO65000.1 - 3.2e-135 451.5 6.4 3.6e-135 451.4 6.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF892 PF05974.12 EFO65000.1 - 0.0017 18.4 0.0 0.0044 17.0 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF892) TetR_C_14 PF17754.1 EFO65000.1 - 0.0083 16.1 0.3 0.053 13.5 0.1 2.3 2 1 0 2 2 2 1 MftR C-terminal domain DUF2148 PF09918.9 EFO65000.1 - 1 9.5 4.1 0.39 10.8 0.6 2.2 2 0 0 2 2 2 0 Uncharacterized protein containing a ferredoxin domain (DUF2148) Methyltransf_11 PF08241.12 EFO65001.1 - 4.7e-12 46.4 0.0 6.5e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFO65001.1 - 2.1e-10 40.6 0.0 2.3e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFO65001.1 - 5.5e-10 39.8 0.0 8.1e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFO65001.1 - 5.2e-06 27.1 0.0 7.7e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFO65001.1 - 0.00026 20.6 0.0 0.00045 19.8 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase small domain NodS PF05401.11 EFO65001.1 - 0.0018 17.9 0.0 0.0024 17.5 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_23 PF13489.6 EFO65001.1 - 0.011 15.6 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Lipase_3 PF01764.25 EFO65002.1 - 1.4e-17 63.8 0.0 2.9e-17 62.9 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) IF-2B PF01008.17 EFO65004.1 - 0.034 13.4 0.0 0.1 11.8 0.0 1.8 1 0 0 1 1 1 0 Initiation factor 2 subunit family Ank_2 PF12796.7 EFO65005.1 - 4.9e-79 261.0 22.7 1.6e-12 47.8 0.1 8.8 2 2 6 9 9 9 9 Ankyrin repeats (3 copies) Ank PF00023.30 EFO65005.1 - 2.8e-40 135.0 25.7 0.00017 21.9 0.0 14.9 14 1 1 15 15 15 9 Ankyrin repeat Ank_4 PF13637.6 EFO65005.1 - 1.7e-39 133.7 22.8 1.1e-06 29.1 0.1 11.5 7 4 4 12 12 12 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65005.1 - 4.5e-33 109.6 23.1 0.052 14.1 0.0 15.5 15 0 0 15 15 15 10 Ankyrin repeat Ank_5 PF13857.6 EFO65005.1 - 1.1e-32 111.7 27.2 0.00019 21.7 0.1 13.4 3 3 11 15 15 15 9 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO65005.1 - 5.9e-17 61.9 0.0 2.6e-16 59.8 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65005.1 - 3.5e-09 36.3 0.1 2.3e-05 23.8 0.0 3.8 4 1 0 4 4 4 2 Protein tyrosine kinase Tubulin PF00091.25 EFO65008.1 - 1.3e-64 218.0 0.0 2.3e-64 217.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFO65008.1 - 1.2e-34 119.2 0.1 7.7e-29 100.4 0.0 2.3 2 0 0 2 2 2 2 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EFO65008.1 - 2.8e-05 24.4 0.0 6.3e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Eclosion PF04736.12 EFO65008.1 - 0.14 11.9 0.1 0.35 10.6 0.1 1.6 1 0 0 1 1 1 0 Eclosion hormone FAM184 PF15665.5 EFO65011.1 - 3.9e-08 33.3 31.9 3.9e-08 33.3 31.9 8.2 1 1 8 9 9 7 1 Family with sequence similarity 184, A and B TPR_MLP1_2 PF07926.12 EFO65011.1 - 1.2e-06 28.6 39.9 3.1e-05 24.0 12.1 12.0 4 3 8 12 12 12 3 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 EFO65011.1 - 7e-05 21.9 14.9 7e-05 21.9 14.9 8.9 2 2 6 9 9 9 3 Spc7 kinetochore protein GAS PF13851.6 EFO65011.1 - 0.00097 18.5 14.5 0.00097 18.5 14.5 9.3 1 1 8 9 9 8 3 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 EFO65011.1 - 0.0011 19.4 15.6 0.0011 19.4 15.6 8.4 1 1 5 6 6 4 2 Fez1 Golgin_A5 PF09787.9 EFO65011.1 - 0.0019 17.7 24.2 0.0019 17.7 24.2 7.9 1 1 6 8 8 7 3 Golgin subfamily A member 5 DUF4200 PF13863.6 EFO65011.1 - 0.0023 18.3 8.6 0.0023 18.3 8.6 12.3 2 2 12 14 14 12 3 Domain of unknown function (DUF4200) CCDC144C PF14915.6 EFO65011.1 - 0.0026 16.9 16.0 0.0026 16.9 16.0 7.3 1 1 5 6 6 5 2 CCDC144C protein coiled-coil region TolA_bind_tri PF16331.5 EFO65011.1 - 0.0034 17.4 6.3 0.0034 17.4 6.3 13.8 6 5 7 15 15 14 3 TolA binding protein trimerisation DUF724 PF05266.14 EFO65011.1 - 0.0042 16.9 10.5 0.0042 16.9 10.5 10.6 2 2 10 12 12 10 4 Protein of unknown function (DUF724) HMMR_N PF15905.5 EFO65011.1 - 0.0049 16.4 13.6 0.0049 16.4 13.6 7.2 1 1 4 7 7 7 3 Hyaluronan mediated motility receptor N-terminal Baculo_PEP_C PF04513.12 EFO65011.1 - 0.006 16.6 9.0 0.006 16.6 9.0 10.6 2 1 5 9 9 9 3 Baculovirus polyhedron envelope protein, PEP, C terminus SlyX PF04102.12 EFO65011.1 - 0.016 15.8 3.6 0.016 15.8 3.6 16.6 5 4 12 19 19 19 0 SlyX Filament PF00038.21 EFO65011.1 - 0.021 14.4 158.8 0.02 14.5 14.1 7.6 1 1 4 6 6 5 0 Intermediate filament protein DUF5409 PF17421.2 EFO65011.1 - 0.34 11.7 0.8 0.8 10.5 0.8 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5409) AAA_13 PF13166.6 EFO65011.1 - 0.7 8.5 134.9 0.055 12.1 13.7 6.7 1 1 5 6 6 6 0 AAA domain DUF3584 PF12128.8 EFO65011.1 - 1.1 6.7 157.6 0.032 11.8 39.9 4.7 1 1 3 4 4 4 0 Protein of unknown function (DUF3584) MMR_HSR1_Xtn PF16897.5 EFO65014.1 - 3.8e-38 129.7 0.1 7e-38 128.9 0.1 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EFO65014.1 - 6.6e-22 77.7 0.1 1.7e-21 76.4 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EFO65014.1 - 5.5e-15 55.2 0.1 1e-14 54.3 0.1 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EFO65014.1 - 9.1e-13 48.0 0.1 5.2e-12 45.6 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFO65014.1 - 1.9e-05 24.8 0.4 0.0042 17.1 0.0 2.6 1 1 1 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 EFO65014.1 - 0.00048 19.7 0.1 0.076 12.5 0.0 3.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 EFO65014.1 - 0.0024 16.9 0.3 0.0078 15.2 0.1 1.8 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB SRPRB PF09439.10 EFO65014.1 - 0.003 17.0 0.1 0.0058 16.1 0.1 1.6 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit cobW PF02492.19 EFO65014.1 - 0.76 9.3 3.2 4.1 7.0 0.2 2.9 2 1 1 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain VSP PF03302.13 EFO65015.1 - 3e-13 49.4 110.0 0.00013 21.0 31.6 5.8 1 1 3 4 4 4 4 Giardia variant-specific surface protein cEGF PF12662.7 EFO65015.1 - 0.018 15.0 15.3 0.033 14.1 1.0 4.9 4 0 0 4 4 4 0 Complement Clr-like EGF-like Insulin_TMD PF17870.1 EFO65015.1 - 0.46 10.6 1.9 0.96 9.6 1.9 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment HTH_23 PF13384.6 EFO65016.1 - 0.033 14.0 0.2 0.059 13.2 0.2 1.3 1 0 0 1 1 1 0 Homeodomain-like domain Pkinase PF00069.25 EFO65017.1 - 1.7e-40 139.1 0.0 2.4e-33 115.6 0.0 2.8 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65017.1 - 2.1e-22 79.7 0.0 2.6e-17 63.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFO65017.1 - 2e-07 30.6 0.0 3.8e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like S6PP PF05116.13 EFO65017.1 - 0.015 14.8 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase Kdo PF06293.14 EFO65017.1 - 0.08 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Arf PF00025.21 EFO65018.1 - 1.3e-59 200.6 0.0 1.5e-59 200.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EFO65018.1 - 3.3e-14 52.8 0.0 3.9e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFO65018.1 - 2.9e-12 46.9 0.0 3.9e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFO65018.1 - 3.7e-11 42.8 0.0 5.1e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFO65018.1 - 1.3e-08 34.5 0.0 1.7e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EFO65018.1 - 4.5e-08 32.7 0.1 4.5e-05 22.8 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 EFO65018.1 - 5.2e-05 23.3 0.0 7.6e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFO65018.1 - 0.002 17.7 0.0 0.023 14.3 0.0 2.0 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 EFO65018.1 - 0.059 13.5 0.1 0.093 12.9 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFO65018.1 - 0.12 12.9 0.1 0.17 12.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EFO65018.1 - 0.16 12.2 0.1 1.7 8.9 0.1 2.0 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 EFO65018.1 - 0.19 11.3 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Arm PF00514.23 EFO65019.1 - 2.9e-35 119.2 18.1 1.4e-06 28.1 0.1 8.8 9 0 0 9 9 9 7 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EFO65019.1 - 1.2e-13 51.2 11.7 0.002 18.5 1.0 5.8 2 2 5 7 7 7 6 HEAT repeats HEAT PF02985.22 EFO65019.1 - 1e-11 44.0 9.9 0.037 14.3 0.0 7.0 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 EFO65019.1 - 1.1e-11 45.0 19.6 0.0047 17.4 0.9 6.9 6 2 2 8 8 8 4 HEAT-like repeat Cnd1 PF12717.7 EFO65019.1 - 3.3e-08 33.7 0.1 0.53 10.3 0.0 3.4 1 1 2 3 3 3 3 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EFO65019.1 - 6.7e-06 24.9 4.5 0.011 14.3 1.8 3.3 2 1 0 3 3 3 3 Adaptin N terminal region RICTOR_V PF14668.6 EFO65019.1 - 7.6e-05 22.9 0.1 0.2 11.9 0.0 3.9 3 1 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 Arm_2 PF04826.13 EFO65019.1 - 0.00043 19.8 0.0 1.3 8.4 0.0 4.0 3 2 1 4 4 4 1 Armadillo-like Proteasom_PSMB PF10508.9 EFO65019.1 - 0.00052 18.6 1.5 0.37 9.3 0.2 2.2 1 1 1 2 2 2 2 Proteasome non-ATPase 26S subunit DNA_alkylation PF08713.11 EFO65019.1 - 0.0034 17.1 0.0 29 4.3 0.0 4.2 2 1 2 4 4 4 0 DNA alkylation repair enzyme V-ATPase_H_C PF11698.8 EFO65019.1 - 0.0086 16.2 0.1 1.6 8.9 0.0 3.2 2 1 2 4 4 4 1 V-ATPase subunit H HEAT_PBS PF03130.16 EFO65019.1 - 0.013 16.2 10.2 3.3 8.7 0.9 5.6 7 0 0 7 7 5 0 PBS lyase HEAT-like repeat RICTOR_N PF14664.6 EFO65019.1 - 0.032 13.2 1.2 0.11 11.4 0.1 2.5 2 2 1 3 3 3 0 Rapamycin-insensitive companion of mTOR, N-term GatB_Yqey PF02637.18 EFO65019.1 - 0.057 13.3 0.2 1.9 8.4 0.0 2.8 2 1 0 2 2 2 0 GatB domain IP_trans PF02121.18 EFO65020.1 - 3e-46 158.0 6.7 9.4e-45 153.1 6.7 2.1 1 1 0 1 1 1 1 Phosphatidylinositol transfer protein MORN PF02493.20 EFO65021.1 - 0.094 12.7 1.5 0.2 11.6 0.3 2.3 2 0 0 2 2 2 0 MORN repeat ECSCR PF15820.5 EFO65021.1 - 0.13 12.1 0.4 0.38 10.6 0.4 1.7 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Glug PF07581.12 EFO65021.1 - 5.1 7.7 62.5 0.64 10.5 1.0 12.6 13 0 0 13 13 13 0 The GLUG motif DHR-2 PF06920.13 EFO65022.1 - 8.8e-24 84.0 12.5 4.5e-11 42.1 7.3 4.0 3 1 0 3 3 3 2 Dock homology region 2 DOCK-C2 PF14429.6 EFO65022.1 - 1.1e-11 45.0 2.0 8.8e-10 38.7 2.0 3.0 1 1 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins Got1 PF04178.12 EFO65022.1 - 0.092 13.2 0.1 0.33 11.4 0.1 1.9 1 0 0 1 1 1 0 Got1/Sft2-like family Fer2 PF00111.27 EFO65023.1 - 2.8e-10 40.0 0.2 3.9e-10 39.5 0.2 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Cpn60_TCP1 PF00118.24 EFO65024.1 - 5.3e-63 213.3 6.8 8.9e-63 212.6 6.8 1.3 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family SET PF00856.28 EFO65026.1 - 5.1e-10 40.0 0.3 9.5e-10 39.1 0.3 1.8 1 1 0 1 1 1 1 SET domain Dicer_N PF17895.1 EFO65028.1 - 5e-79 263.2 0.2 9.6e-79 262.3 0.2 1.5 1 0 0 1 1 1 1 Giardia Dicer N-terminal domain Ribonuclease_3 PF00636.26 EFO65028.1 - 4e-26 91.7 0.1 6.6e-12 46.0 0.0 2.7 2 1 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EFO65028.1 - 5.3e-17 62.2 0.0 3e-09 37.1 0.0 2.4 2 0 0 2 2 2 2 Ribonuclease-III-like PAZ PF02170.22 EFO65028.1 - 5.6e-07 29.4 0.0 9.2e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 PAZ domain MORN PF02493.20 EFO65029.1 - 1.5e-88 285.7 120.7 1.1e-06 28.1 1.3 30.8 32 0 0 32 32 32 24 MORN repeat p25-alpha PF05517.12 EFO65030.1 - 8.1e-16 58.6 3.1 1.7e-11 44.6 0.7 2.1 1 1 1 2 2 2 2 p25-alpha FAM110_N PF14161.6 EFO65030.1 - 0.017 15.3 0.5 0.068 13.4 0.5 1.8 1 1 1 2 2 2 0 Centrosome-associated N terminus DNA_pol3_tau_4 PF12168.8 EFO65030.1 - 0.019 15.5 0.5 3.2 8.4 0.5 2.7 1 1 1 2 2 2 0 DNA polymerase III subunits tau domain IV DnaB-binding SET PF00856.28 EFO65031.1 - 4.4e-13 50.0 0.0 1.3e-12 48.4 0.0 1.9 1 0 0 1 1 1 1 SET domain Pre-SET PF05033.16 EFO65031.1 - 0.017 15.7 0.1 0.017 15.7 0.1 3.7 4 1 0 4 4 4 0 Pre-SET motif DHR-2 PF06920.13 EFO65033.1 - 2.2e-20 72.8 4.4 3.4e-11 42.5 1.4 2.5 2 0 0 2 2 2 2 Dock homology region 2 DOCK-C2 PF14429.6 EFO65033.1 - 5.2e-11 42.7 0.0 7.7e-09 35.6 0.0 2.8 1 1 1 2 2 2 2 C2 domain in Dock180 and Zizimin proteins UQ_con PF00179.26 EFO65035.1 - 2.5e-12 46.6 0.0 3.6e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme GAS PF13851.6 EFO65036.1 - 0.077 12.3 0.1 0.077 12.3 0.1 4.0 2 2 0 3 3 3 0 Growth-arrest specific micro-tubule binding DUF883 PF05957.13 EFO65036.1 - 2.4 8.8 20.2 1.1 9.9 5.5 3.7 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF883) Fez1 PF06818.15 EFO65036.1 - 2.8 8.3 24.8 3.1 8.2 1.8 3.3 2 1 1 3 3 3 0 Fez1 PspB PF06667.12 EFO65036.1 - 4.7 7.3 5.4 45 4.2 0.4 3.2 2 0 0 2 2 2 0 Phage shock protein B KIAA1430 PF13879.6 EFO65036.1 - 7.9 7.3 20.2 0.91 10.3 4.1 3.5 2 2 0 2 2 2 0 KIAA1430 homologue Ank_4 PF13637.6 EFO65037.1 - 4.9e-10 39.7 0.0 1.2e-09 38.4 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFO65037.1 - 0.00018 22.0 0.0 0.00045 20.7 0.0 1.6 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO65037.1 - 0.0002 21.6 0.0 0.36 11.2 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65037.1 - 0.0049 17.3 0.1 0.54 11.0 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 EFO65037.1 - 0.061 13.8 0.0 0.62 10.6 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeat Keratin_assoc PF09775.9 EFO65038.1 - 0.21 11.2 2.8 0.38 10.4 0.1 2.6 2 0 0 2 2 2 0 Keratinocyte-associated protein 2 SAPS PF04499.15 EFO65038.1 - 0.54 9.0 3.9 11 4.7 1.6 2.4 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein RR_TM4-6 PF06459.12 EFO65038.1 - 0.82 9.4 7.4 1.5 8.6 7.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spore_coat_CotO PF14153.6 EFO65038.1 - 7.2 6.5 10.4 13 5.6 10.4 1.3 1 0 0 1 1 1 0 Spore coat protein CotO HSCB_C PF07743.13 EFO65039.1 - 5.7e-10 39.5 2.5 6.6e-10 39.3 0.2 2.1 3 0 0 3 3 3 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 EFO65039.1 - 4.6e-06 26.7 0.2 1.3e-05 25.2 0.2 1.7 1 1 0 1 1 1 1 DnaJ domain zinc_ribbon_2 PF13240.6 EFO65039.1 - 0.023 14.4 0.3 0.047 13.4 0.3 1.5 1 0 0 1 1 1 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 EFO65039.1 - 0.036 13.5 2.9 0.068 12.6 2.9 1.5 1 0 0 1 1 1 0 zinc-ribbon domain HscB_4_cys PF18256.1 EFO65039.1 - 4.5 7.2 7.5 42 4.1 7.5 2.1 1 1 0 1 1 1 0 Co-chaperone HscB tetracysteine metal binding motif MRP-S26 PF14943.6 EFO65040.1 - 0.04 13.8 0.3 0.064 13.2 0.3 1.2 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Sad1_UNC PF07738.13 EFO65041.1 - 9.3e-15 54.8 0.0 2.5e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal RTX_C PF08339.10 EFO65041.1 - 0.11 12.6 9.6 0.036 14.1 5.7 2.2 2 0 0 2 2 2 0 RTX C-terminal domain TCTP PF00838.17 EFO65041.1 - 0.41 11.0 11.1 17 5.7 0.0 3.9 2 2 2 4 4 4 0 Translationally controlled tumour protein TNFR_16_TM PF18422.1 EFO65041.1 - 0.68 9.9 2.4 1.3 9.0 2.4 1.4 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain DUF4061 PF13270.6 EFO65041.1 - 0.84 10.0 5.3 1.8 8.9 0.0 3.8 3 1 0 4 4 4 0 Domain of unknown function (DUF4061) AMPK1_CBM PF16561.5 EFO65042.1 - 5e-27 93.9 0.1 7.8e-27 93.3 0.1 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 EFO65042.1 - 4.9e-15 55.5 1.6 9.6e-15 54.6 1.6 1.5 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain CBM_48 PF02922.18 EFO65042.1 - 9.4e-05 22.7 0.0 0.00038 20.7 0.0 2.0 2 0 0 2 2 2 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) CBM53 PF16760.5 EFO65042.1 - 0.095 13.3 0.1 0.29 11.8 0.1 1.8 1 0 0 1 1 1 0 Starch/carbohydrate-binding module (family 53) PAZ PF02170.22 EFO65043.1 - 0.14 11.9 0.1 0.32 10.8 0.1 1.5 1 1 0 2 2 2 0 PAZ domain VSP PF03302.13 EFO65045.1 - 1.1e-23 83.8 45.4 3.8e-20 72.1 13.5 2.1 1 1 1 2 2 2 2 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO65045.1 - 0.0099 16.0 2.9 0.0099 16.0 2.9 3.1 2 2 1 3 3 3 1 Furin-like repeat, cysteine-rich DZR PF12773.7 EFO65045.1 - 0.014 15.4 3.6 0.014 15.4 3.6 3.3 2 1 0 2 2 2 0 Double zinc ribbon stn_TNFRSF12A PF12191.8 EFO65045.1 - 0.096 12.9 1.3 0.14 12.3 0.0 1.9 2 1 1 3 3 3 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain GTP_EFTU PF00009.27 EFO65046.1 - 3.7e-44 150.6 0.9 4.2e-44 150.4 0.9 1.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFO65046.1 - 1.8e-05 24.8 0.1 0.00043 20.3 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFO65046.1 - 0.0036 17.4 0.0 1.7 8.7 0.0 2.2 2 0 0 2 2 2 2 Dynamin family SRPRB PF09439.10 EFO65046.1 - 0.045 13.2 0.1 0.49 9.8 0.0 2.0 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit Septin PF00735.18 EFO65046.1 - 0.056 12.7 0.1 0.16 11.2 0.1 1.6 1 1 0 1 1 1 0 Septin PduV-EutP PF10662.9 EFO65046.1 - 0.06 13.1 0.2 8.3 6.2 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 EFO65046.1 - 0.07 13.3 0.4 5.9 7.1 0.1 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFO65046.1 - 0.14 11.8 0.5 3.1 7.4 0.0 2.1 1 1 1 2 2 2 0 Ras family HATPase_c_3 PF13589.6 EFO65047.1 - 2.3e-07 30.7 0.0 7.2e-07 29.1 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase EloA-BP1 PF15870.5 EFO65047.1 - 0.088 13.1 0.2 0.22 11.7 0.2 1.6 1 0 0 1 1 1 0 ElonginA binding-protein 1 DHC_N1 PF08385.12 EFO65048.1 - 2.6e-122 409.3 11.5 9.6e-79 265.5 0.1 4.0 4 0 0 4 4 4 2 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 EFO65048.1 - 7.6e-120 400.7 12.9 7.6e-120 400.7 12.9 3.3 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.7 EFO65048.1 - 3.8e-116 387.6 0.0 8.6e-116 386.5 0.0 1.6 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region DUF789 PF05623.12 EFO65048.1 - 0.55 9.9 4.3 2.4 7.7 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF789) DUF3502 PF12010.8 EFO65048.1 - 0.75 10.4 4.1 1.7 9.3 0.2 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF3502) FtsJ PF01728.19 EFO65049.1 - 7.4e-23 81.6 0.0 1e-22 81.1 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 EFO65049.1 - 0.045 13.0 0.0 0.087 12.1 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain DUF5524 PF17662.1 EFO65049.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5524) VSP PF03302.13 EFO65050.1 - 8.5e-76 255.4 172.8 2.2e-32 112.4 26.3 6.1 1 1 5 6 6 6 4 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO65050.1 - 0.0089 16.1 2.8 0.014 15.5 0.1 2.4 2 0 0 2 2 2 1 Podoplanin SKG6 PF08693.10 EFO65050.1 - 0.043 13.2 3.7 0.074 12.5 3.7 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Flavodoxin_2 PF02525.17 EFO65051.1 - 2.2e-30 105.9 0.0 2.5e-30 105.7 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 EFO65051.1 - 8.8e-06 25.5 0.0 1e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_4 PF12682.7 EFO65051.1 - 0.052 13.3 0.0 0.075 12.7 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin PAP_assoc PF03828.19 EFO65052.1 - 3.4e-17 62.4 2.6 7.5e-15 54.9 0.7 3.0 2 1 0 2 2 2 1 Cid1 family poly A polymerase FSH1 PF03959.13 EFO65053.1 - 4.3e-21 75.5 0.0 5.3e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 EFO65053.1 - 0.013 15.2 0.0 0.064 12.9 0.0 2.0 2 1 1 3 3 3 0 alpha/beta hydrolase fold Ribosomal_S17_N PF16205.5 EFO65054.1 - 1.2e-28 99.3 0.3 1.2e-28 99.3 0.3 1.8 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EFO65054.1 - 3.2e-27 94.4 1.4 5.1e-27 93.8 1.4 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 Cyclin_N PF00134.23 EFO65055.1 - 8.9e-09 35.2 1.6 8.9e-09 35.2 1.6 2.2 2 1 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFO65055.1 - 6e-06 26.3 0.2 1.4e-05 25.2 0.2 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain U71 PF17474.2 EFO65055.1 - 0.041 13.8 0.0 0.11 12.5 0.0 1.7 2 0 0 2 2 2 0 Tegument protein UL11 homolog AAA_5 PF07728.14 EFO65056.1 - 4.9e-107 353.8 0.1 3.4e-22 78.9 0.0 10.4 10 1 0 10 10 8 8 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFO65056.1 - 7e-25 87.4 0.0 2.5e-07 30.6 0.0 7.5 7 0 0 7 7 7 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFO65056.1 - 2.9e-24 86.4 5.1 8.8e-06 26.2 0.0 7.7 6 0 0 6 6 6 5 AAA ATPase domain AAA_7 PF12775.7 EFO65056.1 - 4.4e-24 85.0 0.0 2.2e-06 27.3 0.0 6.5 6 0 0 6 6 6 5 P-loop containing dynein motor region AAA_lid_7 PF17867.1 EFO65056.1 - 8.5e-23 80.6 3.5 9.5e-10 38.6 0.1 6.1 7 0 0 7 7 5 3 Midasin AAA lid domain AAA PF00004.29 EFO65056.1 - 1.3e-22 80.6 0.4 0.0002 21.8 0.0 7.2 7 0 0 7 7 6 4 ATPase family associated with various cellular activities (AAA) AAA_lid_5 PF17865.1 EFO65056.1 - 4.1e-22 78.3 0.1 5.9e-21 74.5 0.1 2.9 2 0 0 2 2 2 1 Midasin AAA lid domain AAA_6 PF12774.7 EFO65056.1 - 3.3e-18 65.7 1.0 0.0028 16.7 0.1 7.0 6 1 0 6 6 6 4 Hydrolytic ATP binding site of dynein motor region Dynein_heavy PF03028.15 EFO65056.1 - 1.5e-16 60.5 0.0 5.7e-05 23.2 0.0 8.0 7 0 0 7 7 7 2 Dynein heavy chain region D6 P-loop domain AAA_30 PF13604.6 EFO65056.1 - 2.3e-14 53.6 2.3 0.0012 18.6 0.1 6.9 7 0 0 7 7 7 2 AAA domain TsaE PF02367.17 EFO65056.1 - 3.5e-13 49.7 2.5 0.11 12.5 0.0 7.3 8 0 0 8 8 6 3 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 EFO65056.1 - 7.8e-13 48.9 2.2 0.05 13.9 0.0 7.5 6 1 0 6 6 6 2 AAA domain T2SSE PF00437.20 EFO65056.1 - 9.9e-12 44.5 4.8 0.0028 16.7 0.0 6.1 6 0 0 6 6 6 2 Type II/IV secretion system protein AAA_14 PF13173.6 EFO65056.1 - 1.9e-11 44.1 0.0 0.04 13.9 0.0 7.5 8 1 0 8 8 7 2 AAA domain AAA_18 PF13238.6 EFO65056.1 - 1.3e-09 38.7 8.7 0.015 15.9 0.0 7.4 7 0 0 7 7 5 2 AAA domain RsgA_GTPase PF03193.16 EFO65056.1 - 1.5e-09 38.0 4.4 1.4 8.8 0.0 6.5 6 0 0 6 6 6 1 RsgA GTPase Sigma54_activat PF00158.26 EFO65056.1 - 2.1e-09 37.3 0.0 1.3 8.7 0.0 5.8 6 0 0 6 6 5 3 Sigma-54 interaction domain ABC_tran PF00005.27 EFO65056.1 - 3.4e-09 37.3 17.6 0.0086 16.6 0.0 7.7 8 0 0 8 8 6 2 ABC transporter Mg_chelatase PF01078.21 EFO65056.1 - 4.2e-09 36.1 5.8 5.5 6.3 0.0 8.3 8 1 0 8 8 7 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 EFO65056.1 - 7.8e-09 35.2 3.4 3.6 7.4 0.0 6.4 6 0 0 6 6 6 0 P-loop containing region of AAA domain AAA_33 PF13671.6 EFO65056.1 - 1.9e-08 34.6 0.0 4.4 7.5 0.0 6.4 6 0 0 6 6 6 0 AAA domain NACHT PF05729.12 EFO65056.1 - 6.8e-08 32.6 1.6 0.75 9.7 0.1 6.2 6 0 0 6 6 6 2 NACHT domain AAA_8 PF12780.7 EFO65056.1 - 7.2e-08 32.1 0.9 0.0091 15.3 0.0 6.3 7 0 0 7 7 7 1 P-loop containing dynein motor region D4 CPT PF07931.12 EFO65056.1 - 9.8e-08 32.0 1.0 0.9 9.4 0.0 6.3 6 0 0 6 6 6 2 Chloramphenicol phosphotransferase-like protein RNA_helicase PF00910.22 EFO65056.1 - 2.1e-07 31.3 0.1 0.77 10.2 0.0 6.6 6 0 0 6 6 6 1 RNA helicase RuvB_N PF05496.12 EFO65056.1 - 2.5e-07 30.6 3.4 0.015 15.0 0.0 6.2 5 1 1 6 6 6 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EFO65056.1 - 6.3e-06 25.6 1.0 4.2 6.5 0.0 4.4 4 0 0 4 4 4 0 TIP49 P-loop domain Rad17 PF03215.15 EFO65056.1 - 8.3e-06 25.8 2.2 0.056 13.4 0.0 5.1 5 0 0 5 5 5 1 Rad17 P-loop domain DUF815 PF05673.13 EFO65056.1 - 2.6e-05 23.5 0.4 1.7 7.7 0.0 5.3 5 0 0 5 5 5 1 Protein of unknown function (DUF815) MCM PF00493.23 EFO65056.1 - 2.9e-05 23.3 0.1 1 8.4 0.0 4.4 4 0 0 4 4 4 1 MCM P-loop domain IstB_IS21 PF01695.17 EFO65056.1 - 5.7e-05 22.9 0.1 1.4 8.7 0.0 4.8 4 0 0 4 4 4 1 IstB-like ATP binding protein SRP54 PF00448.22 EFO65056.1 - 9.6e-05 22.1 1.6 0.4 10.3 0.0 3.7 5 0 0 5 5 3 2 SRP54-type protein, GTPase domain Sigma54_activ_2 PF14532.6 EFO65056.1 - 0.00011 22.3 0.0 0.007 16.5 0.0 3.6 3 0 0 3 3 3 1 Sigma-54 interaction domain Zeta_toxin PF06414.12 EFO65056.1 - 0.00022 20.6 2.7 19 4.5 0.1 5.9 6 0 0 6 6 6 0 Zeta toxin AAA_28 PF13521.6 EFO65056.1 - 0.0012 19.1 4.6 2.9 8.1 0.0 5.9 6 0 0 6 6 5 1 AAA domain MMR_HSR1 PF01926.23 EFO65056.1 - 0.0013 18.8 0.2 48 4.1 0.0 5.1 5 0 0 5 5 4 0 50S ribosome-binding GTPase AAA_19 PF13245.6 EFO65056.1 - 0.0017 18.7 14.4 1.9 8.8 0.1 7.6 9 0 0 9 9 7 1 AAA domain AAA_25 PF13481.6 EFO65056.1 - 0.0035 16.9 4.4 10 5.7 0.0 5.3 6 0 0 6 6 4 0 AAA domain AAA_24 PF13479.6 EFO65056.1 - 0.0079 15.9 0.1 24 4.6 0.0 4.9 6 0 0 6 6 5 0 AAA domain NTPase_1 PF03266.15 EFO65056.1 - 0.01 15.8 3.5 5.5 6.9 0.1 4.4 4 0 0 4 4 3 0 NTPase dNK PF01712.19 EFO65056.1 - 0.025 14.4 0.2 16 5.2 0.0 4.1 4 0 0 4 4 3 0 Deoxynucleoside kinase Thymidylate_kin PF02223.17 EFO65056.1 - 0.025 14.2 3.2 0.63 9.7 0.0 4.0 4 0 0 4 4 3 0 Thymidylate kinase SRPRB PF09439.10 EFO65056.1 - 0.033 13.6 1.7 9.2 5.7 0.0 4.3 5 0 0 5 5 4 0 Signal recognition particle receptor beta subunit VWA_CoxE PF05762.14 EFO65056.1 - 0.035 13.5 0.1 0.11 11.9 0.1 1.8 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein Bac_DnaA PF00308.18 EFO65056.1 - 0.095 12.5 0.0 3 7.6 0.0 3.1 3 0 0 3 3 2 0 Bacterial dnaA protein AAA_17 PF13207.6 EFO65056.1 - 0.12 12.8 1.4 89 3.5 0.1 4.8 4 0 0 4 4 3 0 AAA domain PRK PF00485.18 EFO65056.1 - 0.2 11.4 3.6 4.4 7.0 0.1 4.6 6 0 0 6 6 6 0 Phosphoribulokinase / Uridine kinase family ATP_bind_1 PF03029.17 EFO65056.1 - 0.25 11.1 6.3 21 4.8 0.1 4.7 6 0 0 6 6 3 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 EFO65056.1 - 0.41 10.4 2.1 73 3.1 0.0 4.5 5 0 0 5 5 5 0 Ethanolamine utilisation - propanediol utilisation MobB PF03205.14 EFO65056.1 - 0.6 10.0 4.9 2.2 8.2 0.1 3.8 4 0 0 4 4 4 0 Molybdopterin guanine dinucleotide synthesis protein B Pkinase PF00069.25 EFO65058.1 - 5.9e-27 94.7 0.0 1.2e-26 93.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65058.1 - 2e-09 37.1 0.0 9.6e-09 34.9 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO65058.1 - 1.1e-06 28.1 0.0 2e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like NAC PF01849.18 EFO65061.1 - 6.9e-06 25.9 0.1 1.1e-05 25.2 0.1 1.4 1 0 0 1 1 1 1 NAC domain CPSF100_C PF13299.6 EFO65061.1 - 0.078 13.2 0.0 0.083 13.1 0.0 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Coatomer_g_Cpla PF16381.5 EFO65062.1 - 0.00043 20.4 0.0 0.0012 18.9 0.0 1.8 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform Synaptonemal_3 PF15191.6 EFO65063.1 - 0.024 14.4 0.1 0.077 12.8 0.1 1.9 1 0 0 1 1 1 0 Synaptonemal complex central element protein 3 TPR_12 PF13424.6 EFO65063.1 - 0.038 14.3 5.1 0.22 11.8 0.5 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat GTP_EFTU PF00009.27 EFO65064.1 - 4.5e-54 183.0 0.1 5.6e-54 182.6 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFO65064.1 - 4.2e-34 117.2 0.0 1.1e-33 115.9 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFO65064.1 - 1.6e-14 54.1 0.2 3.7e-14 52.8 0.2 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFO65064.1 - 6.3e-05 23.0 0.3 0.00088 19.3 0.3 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EFO65064.1 - 0.00021 21.1 0.2 0.00065 19.5 0.2 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Dynamin_N PF00350.23 EFO65064.1 - 0.072 13.1 0.1 15 5.6 0.0 2.4 2 1 0 2 2 2 0 Dynamin family Gtr1_RagA PF04670.12 EFO65064.1 - 0.094 12.1 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Amelogenin PF02948.15 EFO65064.1 - 0.12 13.0 0.6 0.28 11.8 0.0 1.7 2 0 0 2 2 2 0 Amelogenin VSP PF03302.13 EFO65065.1 - 1.7e-85 287.3 164.1 9.8e-45 153.1 25.5 4.5 1 1 3 4 4 4 4 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO65065.1 - 0.00024 21.2 0.2 0.036 14.2 0.0 2.9 2 0 0 2 2 2 2 Podoplanin VSP PF03302.13 EFO65066.1 - 3.4e-99 332.4 252.4 2.2e-72 244.1 82.6 7.3 1 1 6 7 7 7 6 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO65066.1 - 0.0018 18.4 21.9 0.0018 18.4 21.9 16.7 3 2 14 17 17 17 5 Furin-like repeat, cysteine-rich Ephrin_rec_like PF07699.13 EFO65066.1 - 0.0072 16.1 7.0 0.0072 16.1 7.0 21.3 14 7 7 22 22 22 4 Putative ephrin-receptor like DUF4476 PF14771.6 EFO65067.1 - 0.0036 17.6 0.0 0.0049 17.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4476) Lactamase_B PF00753.27 EFO65068.1 - 5.3e-25 88.6 0.0 1.3e-24 87.3 0.0 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFO65068.1 - 0.00076 19.0 0.0 0.0011 18.5 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Ank_2 PF12796.7 EFO65069.1 - 1.3e-87 288.4 22.2 2.3e-12 47.3 0.0 10.1 3 3 6 10 10 10 10 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO65069.1 - 3.7e-44 148.2 25.1 1.8e-05 24.9 0.0 14.7 5 4 10 15 15 15 13 Ankyrin repeats (many copies) Ank PF00023.30 EFO65069.1 - 2.9e-36 122.3 24.7 0.00044 20.6 0.0 15.4 16 1 0 16 16 16 9 Ankyrin repeat Ank_4 PF13637.6 EFO65069.1 - 8.1e-33 112.4 19.9 5.4e-08 33.2 0.0 13.4 8 4 8 16 16 16 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65069.1 - 1.1e-32 108.3 29.1 0.013 15.9 0.0 17.5 18 0 0 18 18 18 9 Ankyrin repeat Golgin_A5 PF09787.9 EFO65069.1 - 0.49 9.8 2.9 0.28 10.6 0.2 1.8 2 0 0 2 2 2 0 Golgin subfamily A member 5 BCIP PF13862.6 EFO65070.1 - 2.9e-17 63.2 0.0 3.8e-17 62.8 0.0 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein Peptidase_S28 PF05577.12 EFO65071.1 - 9e-96 321.3 2.9 1.8e-95 320.3 2.9 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S9 PF00326.21 EFO65071.1 - 0.0017 17.9 0.1 0.0045 16.5 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EFO65071.1 - 0.0056 16.4 0.6 0.07 12.8 0.1 2.4 2 1 1 3 3 3 1 alpha/beta hydrolase fold Snf7 PF03357.21 EFO65072.1 - 2.3e-13 50.1 21.4 3e-13 49.7 21.4 1.1 1 0 0 1 1 1 1 Snf7 YlqD PF11068.8 EFO65072.1 - 0.0014 19.0 15.3 0.0059 17.0 3.8 2.1 2 0 0 2 2 2 2 YlqD protein tRNA-synt_1e PF01406.19 EFO65072.1 - 0.089 12.1 2.4 0.11 11.8 2.4 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain Herpes_U44 PF04533.13 EFO65072.1 - 0.39 10.3 5.5 0.66 9.5 5.4 1.4 1 1 0 1 1 1 0 Herpes virus U44 protein DUF3585 PF12130.8 EFO65072.1 - 0.65 10.1 14.1 2.9 8.0 5.5 2.2 1 1 1 2 2 2 0 Bivalent Mical/EHBP Rab binding domain DUF1633 PF07794.11 EFO65072.1 - 1.9 6.6 8.6 0.14 10.3 2.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1633) Cep57_MT_bd PF06657.13 EFO65072.1 - 1.9 9.0 10.3 1.5 9.3 2.7 2.5 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Cluap1 PF10234.9 EFO65072.1 - 2.4 7.5 16.6 2 7.8 5.3 2.1 1 1 1 2 2 2 0 Clusterin-associated protein-1 RNA_pol_L_2 PF13656.6 EFO65073.1 - 4.9e-24 83.9 0.0 5.8e-24 83.7 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EFO65073.1 - 2.3e-08 33.3 0.0 4.6e-08 32.4 0.0 1.5 1 1 1 2 2 2 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Pkinase PF00069.25 EFO65074.1 - 5.1e-69 232.6 0.0 9.7e-69 231.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65074.1 - 1.2e-49 169.0 0.0 1.9e-49 168.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase NTF-like PF14540.6 EFO65074.1 - 0.00083 19.1 0.5 0.0027 17.5 0.1 2.0 2 0 0 2 2 2 1 Nucleotidyltransferase-like Kinase-like PF14531.6 EFO65074.1 - 0.0011 18.3 0.0 0.0033 16.8 0.0 1.8 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFO65074.1 - 0.01 15.2 0.1 0.022 14.1 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFO65074.1 - 0.013 14.3 0.0 0.027 13.2 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase dCMP_cyt_deam_1 PF00383.23 EFO65075.1 - 4.3e-17 61.8 0.5 5e-17 61.6 0.5 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 EFO65075.1 - 6.6e-13 49.0 1.0 4.6e-12 46.3 0.0 2.0 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region DXP_redisom_C PF08436.12 EFO65075.1 - 0.097 12.8 0.0 3.9 7.7 0.0 2.1 1 1 1 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain LmjF365940-deam PF14421.6 EFO65075.1 - 0.12 12.0 2.1 0.8 9.3 0.1 2.0 1 1 1 2 2 2 0 A distinct subfamily of CDD/CDA-like deaminases EGF_2 PF07974.13 EFO65076.1 - 7.8e-19 67.7 153.9 4e-06 27.1 11.6 14.0 12 2 1 13 13 13 8 EGF-like domain EGF PF00008.27 EFO65076.1 - 0.00024 21.3 140.4 0.018 15.4 4.4 13.3 12 0 0 12 12 12 9 EGF-like domain Glutaredoxin PF00462.24 EFO65078.1 - 3.9e-16 59.0 0.0 8.8e-16 57.9 0.0 1.6 2 0 0 2 2 2 1 Glutaredoxin FAD-oxidase_C PF02913.19 EFO65079.1 - 0.024 14.3 0.0 0.032 13.8 0.0 1.1 1 0 0 1 1 1 0 FAD linked oxidases, C-terminal domain SUI1 PF01253.22 EFO65081.1 - 1.4e-13 51.2 0.0 2.5e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor SUI1 FAM176 PF14851.6 EFO65081.1 - 0.066 12.9 1.5 0.1 12.3 1.5 1.2 1 0 0 1 1 1 0 FAM176 family DUF4788 PF16032.5 EFO65081.1 - 0.086 11.8 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4788) DUF4746 PF15928.5 EFO65081.1 - 0.17 11.3 5.9 0.23 10.9 5.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RRN3 PF05327.11 EFO65081.1 - 0.68 8.4 2.9 0.91 8.0 2.9 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 EFO65081.1 - 5.5 5.2 6.8 7 4.8 6.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Cytomega_UL84 PF06284.11 EFO65081.1 - 8.6 4.7 5.4 12 4.2 5.4 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Pox_RNA_pol_35 PF03396.15 EFO65082.1 - 0.065 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase, 35 kD subunit Baculo_PEP_C PF04513.12 EFO65084.1 - 0.16 12.0 9.3 4.5 7.3 4.8 2.7 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FAM184 PF15665.5 EFO65084.1 - 0.29 10.9 28.6 0.009 15.8 18.5 2.6 2 1 0 2 2 2 0 Family with sequence similarity 184, A and B PIN_8 PF18476.1 EFO65084.1 - 0.86 9.4 18.8 0.3 10.9 6.9 2.4 1 1 1 2 2 2 0 PIN like domain NUDIX_2 PF13869.6 EFO65084.1 - 3.6 7.1 8.9 2 7.9 2.2 3.4 1 1 0 2 2 2 0 Nucleotide hydrolase Y_phosphatase3 PF13350.6 EFO65085.1 - 0.0021 18.1 0.0 0.0042 17.1 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EFO65085.1 - 0.0075 15.9 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EFO65085.1 - 0.065 13.1 0.1 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Las1 PF04031.13 EFO65087.1 - 3.7e-33 114.8 0.1 8e-33 113.7 0.1 1.5 1 0 0 1 1 1 1 Las1-like Dynein_C PF18199.1 EFO65088.1 - 3.2e-81 272.9 0.2 3.6e-81 272.8 0.2 1.0 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain PTPA PF03095.15 EFO65090.1 - 8.7e-90 301.2 0.0 9.8e-90 301.0 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein DUF4531 PF15041.6 EFO65090.1 - 0.1 12.7 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4531) UQ_con PF00179.26 EFO65091.1 - 2e-51 173.3 0.0 2.2e-51 173.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFO65091.1 - 0.0011 19.3 0.1 0.0013 19.0 0.1 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 EFO65091.1 - 0.095 12.4 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Pkinase PF00069.25 EFO65093.1 - 1.2e-51 175.6 0.0 1.9e-51 175.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65093.1 - 9.7e-44 149.6 0.0 1.6e-43 148.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFO65093.1 - 1.6e-05 23.9 0.0 3e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase PRKG1_interact PF15898.5 EFO65093.1 - 0.0032 18.4 1.6 0.0047 17.8 0.3 1.9 2 0 0 2 2 2 1 cGMP-dependent protein kinase interacting domain Haspin_kinase PF12330.8 EFO65093.1 - 0.045 12.7 0.1 0.072 12.0 0.1 1.4 1 0 0 1 1 1 0 Haspin like kinase domain DivIC PF04977.15 EFO65093.1 - 0.13 12.1 0.2 0.43 10.4 0.2 1.9 1 0 0 1 1 1 0 Septum formation initiator ZapB PF06005.12 EFO65093.1 - 0.51 10.8 5.6 0.13 12.7 1.4 2.0 2 0 0 2 2 2 0 Cell division protein ZapB CAF1 PF04857.20 EFO65095.1 - 2.2e-15 56.6 0.2 2.1e-09 37.0 0.0 2.9 1 1 1 2 2 2 2 CAF1 family ribonuclease Ank_2 PF12796.7 EFO65096.1 - 3.1e-27 95.0 1.1 8.4e-13 48.7 0.3 4.4 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EFO65096.1 - 4.2e-17 61.8 3.5 0.0011 19.4 0.0 5.2 5 1 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EFO65096.1 - 3.4e-15 55.9 2.3 0.0015 18.8 0.0 5.5 6 0 0 6 6 6 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO65096.1 - 8.8e-15 54.9 4.4 1.1e-05 25.9 0.2 6.0 5 1 1 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65096.1 - 1.1e-13 50.0 6.1 0.011 16.2 0.0 7.1 8 0 0 8 8 8 3 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO65096.1 - 2.4e-07 30.5 15.8 2.4e-07 30.5 15.8 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO65096.1 - 0.01 15.7 13.9 0.025 14.4 13.9 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 IFT57 PF10498.9 EFO65098.1 - 0.0064 15.5 0.9 0.0091 15.0 0.9 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 DUF3552 PF12072.8 EFO65098.1 - 0.01 15.3 3.8 0.015 14.8 3.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) eIF3_N PF09440.10 EFO65098.1 - 0.06 13.8 0.1 0.14 12.6 0.0 1.6 1 1 0 1 1 1 0 eIF3 subunit 6 N terminal domain DUF2333 PF10095.9 EFO65098.1 - 0.11 11.4 0.1 0.16 11.0 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) Spc7 PF08317.11 EFO65098.1 - 0.7 8.7 6.0 0.99 8.2 6.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Ank_2 PF12796.7 EFO65099.1 - 3.4e-47 158.9 13.9 3.7e-11 43.4 0.0 6.4 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO65099.1 - 9.6e-20 68.6 13.3 0.059 13.9 0.0 11.0 12 0 0 12 12 12 6 Ankyrin repeat Ank_5 PF13857.6 EFO65099.1 - 2.2e-19 69.3 7.6 0.0033 17.7 0.0 8.4 5 3 2 9 9 9 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO65099.1 - 1.3e-18 67.1 9.0 0.0015 19.0 0.1 8.3 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO65099.1 - 4.3e-14 52.2 12.9 0.0044 17.4 0.0 10.2 10 1 0 10 10 10 3 Ankyrin repeat Ephrin_rec_like PF07699.13 EFO65100.1 - 0.00063 19.5 2.6 0.00063 19.5 2.6 14.1 9 6 3 12 12 12 3 Putative ephrin-receptor like VSP PF03302.13 EFO65100.1 - 0.00088 18.2 163.7 0.019 13.8 26.6 6.9 1 1 1 3 3 3 2 Giardia variant-specific surface protein GAPT PF11770.8 EFO65100.1 - 0.15 11.9 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) cEGF PF12662.7 EFO65100.1 - 0.2 11.6 0.1 0.2 11.6 0.1 10.5 8 1 0 8 8 8 0 Complement Clr-like EGF-like Mnd1 PF03962.15 EFO65101.1 - 2.3e-17 63.0 0.0 3.9e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 Mnd1 HTH domain LZ3wCH PF18517.1 EFO65101.1 - 9.9e-14 51.2 0.1 2.6e-13 49.9 0.1 1.8 1 0 0 1 1 1 1 Leucine zipper with capping helix domain Penicillinase_R PF03965.16 EFO65101.1 - 0.00058 20.2 0.4 0.0011 19.3 0.3 1.6 1 1 0 1 1 1 1 Penicillinase repressor TrmB PF01978.19 EFO65101.1 - 0.001 18.9 0.0 0.036 13.9 0.0 2.5 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB GntR PF00392.21 EFO65101.1 - 0.026 14.2 0.0 0.067 12.9 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family eIF3_N PF09440.10 EFO65101.1 - 0.19 12.2 5.2 0.16 12.4 3.1 1.8 2 0 0 2 2 2 0 eIF3 subunit 6 N terminal domain DUF4407 PF14362.6 EFO65101.1 - 0.94 8.8 6.4 2.6 7.3 6.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 EFO65101.1 - 2.7 7.8 8.7 0.53 10.1 3.1 2.4 1 1 2 3 3 3 0 Septum formation initiator AAA_23 PF13476.6 EFO65101.1 - 5.8 7.4 11.1 16 5.9 11.1 1.8 1 1 0 1 1 1 0 AAA domain Pkinase PF00069.25 EFO65103.1 - 2.7e-13 49.9 0.2 2.7e-08 33.5 0.1 3.7 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65103.1 - 2.8e-06 26.8 0.1 0.00029 20.2 0.1 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase Acetyltransf_1 PF00583.25 EFO65104.1 - 3.4e-16 59.5 0.0 4.5e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFO65104.1 - 8.7e-10 38.6 0.0 1.5e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFO65104.1 - 1.2e-09 38.4 0.1 2.4e-09 37.5 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFO65104.1 - 0.0039 17.3 0.0 0.0069 16.5 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase UPF0113 PF03657.13 EFO65104.1 - 0.033 14.4 0.1 1.7 8.9 0.0 2.4 1 1 1 2 2 2 0 UPF0113 PUA domain HHV-5_US34A PF17087.5 EFO65106.1 - 0.062 13.5 2.8 1.2 9.3 0.4 2.5 2 0 0 2 2 2 0 Herpesvirus US34A protein family VSP PF03302.13 EFO65107.1 - 2e-40 138.9 203.1 6.7e-29 100.9 65.2 6.3 1 1 3 4 4 4 4 Giardia variant-specific surface protein SMAP PF15477.6 EFO65108.1 - 0.028 15.3 2.5 0.87 10.6 0.7 2.9 2 0 0 2 2 2 0 Small acidic protein family YebO PF13974.6 EFO65108.1 - 0.62 10.2 6.0 2.3 8.3 0.1 3.1 3 1 0 3 3 3 0 YebO-like protein FUSC PF04632.12 EFO65108.1 - 0.81 8.1 13.7 1.1 7.7 13.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family TMPIT PF07851.13 EFO65108.1 - 8.1 5.6 12.9 0.5 9.6 6.6 2.1 2 1 0 2 2 2 0 TMPIT-like protein Pribosyltran_N PF13793.6 EFO65110.1 - 2.2e-36 124.3 0.1 6.8e-36 122.7 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EFO65110.1 - 2.9e-24 86.1 0.3 3.6e-22 79.3 0.1 2.4 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EFO65110.1 - 3.9e-15 55.7 0.2 7.2e-15 54.9 0.2 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain WhiA_N PF10298.9 EFO65110.1 - 0.026 14.5 0.1 0.062 13.4 0.1 1.6 1 0 0 1 1 1 0 WhiA N-terminal LAGLIDADG-like domain PC_rep PF01851.22 EFO65111.1 - 2.5e-18 65.5 7.1 8.3e-05 22.8 0.0 5.9 5 0 0 5 5 5 4 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EFO65111.1 - 9.7e-05 22.7 0.5 0.0041 17.5 0.3 2.6 2 0 0 2 2 2 1 HEAT repeats RPN2_C PF18004.1 EFO65111.1 - 0.018 15.0 0.0 0.018 15.0 0.0 2.2 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain APG6_N PF17675.1 EFO65112.1 - 0.006 17.1 10.1 0.006 17.1 10.1 5.7 4 2 1 6 6 6 3 Apg6 coiled-coil region MSG PF02349.15 EFO65112.1 - 0.21 11.8 4.9 1.4 9.2 4.9 2.5 1 0 0 1 1 1 0 Major surface glycoprotein Mt_ATP-synt_D PF05873.12 EFO65112.1 - 2.6 7.9 8.1 8 6.3 0.7 3.9 3 0 0 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) G-gamma PF00631.22 EFO65112.1 - 8.9 6.4 6.7 2.9 7.9 0.1 3.3 3 0 0 3 3 3 0 GGL domain FKBP_C PF00254.28 EFO65113.1 - 1.1e-24 86.5 0.0 1.3e-24 86.4 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase ANAPC4_WD40 PF12894.7 EFO65115.1 - 0.031 14.5 0.0 0.077 13.3 0.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain EI24 PF07264.11 EFO65116.1 - 0.00033 21.0 4.1 0.011 16.0 5.6 2.1 1 1 1 2 2 2 2 Etoposide-induced protein 2.4 (EI24) VirB3 PF05101.13 EFO65116.1 - 3 8.1 8.0 1.1 9.5 0.9 2.2 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein Nup54 PF13874.6 EFO65118.1 - 1.8e-11 44.3 0.4 5.3e-11 42.8 0.0 1.9 2 1 0 3 3 3 1 Nucleoporin complex subunit 54 DUF948 PF06103.11 EFO65118.1 - 0.0074 16.5 0.3 0.016 15.5 0.3 1.5 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) KxDL PF10241.9 EFO65118.1 - 0.018 15.3 0.4 0.018 15.3 0.4 2.4 3 0 0 3 3 3 0 Uncharacterized conserved protein DUF1952 PF09189.10 EFO65119.1 - 0.19 11.6 0.0 1.6 8.6 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1952) VSP PF03302.13 EFO65120.1 - 1.5e-47 162.4 193.0 9.8e-38 130.0 70.7 5.8 1 1 3 4 4 4 3 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO65120.1 - 0.0029 17.7 8.5 0.0029 17.7 8.5 9.4 2 2 6 9 9 9 3 Furin-like repeat, cysteine-rich SKG6 PF08693.10 EFO65120.1 - 1.1 8.7 5.6 2.3 7.7 5.6 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain SF1-HH PF16275.5 EFO65121.1 - 0.052 13.9 0.0 0.098 13.0 0.0 1.3 1 0 0 1 1 1 0 Splicing factor 1 helix-hairpin domain Lipase_3 PF01764.25 EFO65123.1 - 5.7e-09 36.0 0.0 9.5e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) SRP54 PF00448.22 EFO65124.1 - 1.2e-70 237.2 0.0 2.1e-70 236.3 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EFO65124.1 - 1.5e-24 86.5 0.9 1.5e-24 86.5 0.9 3.6 2 1 1 3 3 3 1 Signal peptide binding domain MeaB PF03308.16 EFO65124.1 - 4.9e-05 22.5 0.1 0.0035 16.4 0.0 2.3 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 EFO65124.1 - 0.0023 18.0 0.0 0.0077 16.3 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain SRP54_N PF02881.19 EFO65124.1 - 0.015 15.5 0.1 0.043 14.0 0.1 1.9 1 0 0 1 1 1 0 SRP54-type protein, helical bundle domain cobW PF02492.19 EFO65124.1 - 0.041 13.5 0.7 0.45 10.1 0.2 2.5 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain APS_kinase PF01583.20 EFO65124.1 - 0.046 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase MobB PF03205.14 EFO65124.1 - 0.05 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.6 EFO65124.1 - 0.052 13.9 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EFO65124.1 - 0.085 13.0 0.1 0.19 11.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain DUF3450 PF11932.8 EFO65126.1 - 0.0019 17.6 3.7 0.0019 17.6 3.7 5.2 3 2 3 6 6 6 2 Protein of unknown function (DUF3450) Tup_N PF08581.10 EFO65126.1 - 0.0083 16.4 4.7 0.0083 16.4 4.7 7.4 8 1 2 10 10 10 1 Tup N-terminal DUF4250 PF14056.6 EFO65126.1 - 0.075 13.0 0.2 0.075 13.0 0.2 4.3 5 0 0 5 5 5 0 Domain of unknown function (DUF4250) TSC22 PF01166.18 EFO65126.1 - 0.079 13.3 17.6 7.7 6.9 0.1 6.2 3 2 1 5 5 5 0 TSC-22/dip/bun family DUF3800 PF12686.7 EFO65126.1 - 0.089 13.4 0.6 15 6.3 0.6 3.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) Mito_fiss_reg PF05308.11 EFO65126.1 - 0.21 11.7 16.0 0.94 9.5 6.1 2.8 2 1 0 2 2 2 0 Mitochondrial fission regulator XhlA PF10779.9 EFO65126.1 - 2.2 8.6 14.6 0.066 13.4 0.8 4.8 3 1 1 4 4 4 0 Haemolysin XhlA DUF3037 PF11236.8 EFO65126.1 - 9.1 6.7 12.7 0.73 10.3 0.2 4.1 4 1 0 4 4 4 0 Protein of unknown function (DUF3037) Filament PF00038.21 EFO65126.1 - 9.4 5.7 50.2 0.02 14.5 7.1 5.0 3 2 2 5 5 5 0 Intermediate filament protein zf-MIZ PF02891.20 EFO65127.1 - 2.2e-11 43.3 0.4 5.6e-11 42.0 0.4 1.8 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EFO65127.1 - 0.00043 20.0 0.2 0.00085 19.1 0.2 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit YfhO PF09586.10 EFO65129.1 - 0.21 9.8 0.0 0.27 9.4 0.0 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO TetR_C_19 PF17924.1 EFO65130.1 - 0.13 12.9 0.2 1.6 9.3 0.0 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DWNN PF08783.11 EFO65131.1 - 1.8 8.9 10.2 0.12 12.7 1.0 3.8 3 1 1 4 4 4 0 DWNN domain Pox_A_type_inc PF04508.12 EFO65131.1 - 1.8 8.5 10.0 17 5.5 0.0 5.8 6 0 0 6 6 6 0 Viral A-type inclusion protein repeat TSC22 PF01166.18 EFO65132.1 - 0.00012 22.3 14.5 0.08 13.3 1.0 4.7 3 2 2 5 5 5 4 TSC-22/dip/bun family CdiI_3 PF18616.1 EFO65132.1 - 0.032 14.1 3.2 0.96 9.4 0.1 2.9 2 1 1 3 3 3 0 CDI immunity proteins T3SS_LEE_assoc PF13327.6 EFO65132.1 - 0.1 12.6 0.7 0.26 11.3 0.7 1.7 1 1 0 1 1 1 0 Type III secretion system subunit bZIP_2 PF07716.15 EFO65132.1 - 0.24 11.5 0.3 0.24 11.5 0.3 3.9 4 0 0 4 4 4 0 Basic region leucine zipper Shugoshin_N PF07558.11 EFO65132.1 - 0.48 10.3 10.6 0.85 9.5 0.1 3.8 4 0 0 4 4 4 0 Shugoshin N-terminal coiled-coil region DEAD PF00270.29 EFO65133.1 - 3.1e-41 141.1 2.4 3.1e-41 141.1 2.4 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO65133.1 - 4.3e-30 104.3 0.6 2.6e-29 101.8 0.2 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFO65133.1 - 6.7e-05 23.0 0.0 0.00012 22.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EFO65133.1 - 0.0011 18.8 1.1 0.0021 17.8 1.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFO65133.1 - 0.0061 16.8 1.3 0.035 14.4 1.3 2.1 1 1 0 1 1 1 1 AAA domain Ribosomal_L10 PF00466.20 EFO65133.1 - 0.019 15.1 0.1 8.6 6.6 0.0 2.6 1 1 1 2 2 2 0 Ribosomal protein L10 TniB PF05621.11 EFO65133.1 - 0.043 13.2 0.1 0.089 12.2 0.1 1.5 1 0 0 1 1 1 0 Bacterial TniB protein CMS1 PF14617.6 EFO65133.1 - 0.078 12.3 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF4476 PF14771.6 EFO65133.1 - 0.15 12.4 1.1 2 8.8 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4476) AAA_19 PF13245.6 EFO65133.1 - 0.15 12.4 0.6 0.9 9.9 0.4 2.0 2 0 0 2 2 2 0 AAA domain WD40 PF00400.32 EFO65134.1 - 3.4e-08 34.0 8.0 0.00066 20.4 0.0 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO65134.1 - 0.02 15.2 0.0 6.2 7.2 0.0 3.7 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain XLF PF09302.11 EFO65135.1 - 0.082 13.1 6.8 1.1 9.4 0.1 3.7 3 1 0 3 3 3 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component Sin3_corepress PF08295.12 EFO65135.1 - 0.084 12.9 0.4 0.32 11.1 0.1 2.1 2 0 0 2 2 2 0 Sin3 family co-repressor DASH_Hsk3 PF08227.11 EFO65135.1 - 4 7.9 9.4 0.47 10.8 1.9 2.9 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like Csm1_N PF18504.1 EFO65135.1 - 4.8 7.6 13.0 0.9 9.9 0.6 3.9 4 0 0 4 4 4 0 Csm1 N-terminal domain LRR_6 PF13516.6 EFO65136.1 - 4.9e-07 29.3 8.4 0.53 10.5 0.2 5.4 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.7 EFO65136.1 - 0.47 10.9 4.2 1.5e+02 3.0 0.3 5.0 5 1 0 5 5 5 0 Leucine Rich repeats (2 copies) Cyclin_N PF00134.23 EFO65137.1 - 1.1e-13 51.0 0.3 2.8e-13 49.7 0.1 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFO65137.1 - 1.9e-05 24.7 1.8 0.0003 20.9 1.8 2.4 1 1 0 1 1 1 1 Cyclin, C-terminal domain Leu_zip PF15294.6 EFO65138.1 - 1.6e-07 31.1 11.7 2.4e-05 24.0 5.5 2.1 1 1 1 2 2 2 2 Leucine zipper ABC_tran_CTD PF16326.5 EFO65138.1 - 0.015 15.5 7.5 0.015 15.5 7.5 2.7 3 0 0 3 3 3 0 ABC transporter C-terminal domain DUF3734 PF12536.8 EFO65138.1 - 0.12 12.8 5.1 0.13 12.6 1.4 2.6 2 1 0 3 3 3 0 Patatin phospholipase FAM76 PF16046.5 EFO65138.1 - 0.13 11.6 8.8 0.14 11.5 8.8 1.1 1 0 0 1 1 1 0 FAM76 protein TMF_TATA_bd PF12325.8 EFO65138.1 - 0.16 12.2 17.1 0.51 10.6 11.1 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding NPV_P10 PF05531.12 EFO65138.1 - 0.38 11.3 13.0 2.6 8.6 5.6 3.1 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DivIC PF04977.15 EFO65138.1 - 0.61 9.9 9.0 0.89 9.4 4.7 2.5 1 1 1 2 2 2 0 Septum formation initiator Fib_alpha PF08702.10 EFO65138.1 - 1.6 8.9 11.6 4.5 7.5 8.7 2.2 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF2203 PF09969.9 EFO65138.1 - 1.6 9.5 10.5 1.2 9.9 3.2 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) PKcGMP_CC PF16808.5 EFO65138.1 - 2.7 7.9 8.8 1.1 9.2 0.3 3.6 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase FlxA PF14282.6 EFO65138.1 - 7.4 6.6 18.0 0.68 10.0 11.9 2.3 2 1 0 2 2 2 0 FlxA-like protein Csm1_N PF18504.1 EFO65138.1 - 8.5 6.8 15.7 2.1 8.8 3.3 3.4 1 1 2 3 3 3 0 Csm1 N-terminal domain Beach PF02138.18 EFO65139.1 - 2.7e-46 158.2 0.0 8.2e-46 156.6 0.0 1.8 2 0 0 2 2 2 1 Beige/BEACH domain EamA PF00892.20 EFO65141.1 - 0.00025 21.2 2.1 0.00025 21.2 2.1 3.6 3 2 1 4 4 4 1 EamA-like transporter family TPT PF03151.16 EFO65141.1 - 0.0003 20.3 0.4 0.0013 18.1 0.3 2.0 2 0 0 2 2 2 1 Triose-phosphate Transporter family SLC35F PF06027.12 EFO65141.1 - 0.0008 19.0 10.0 0.045 13.2 0.1 2.6 2 1 0 2 2 2 2 Solute carrier family 35 Nuc_sug_transp PF04142.15 EFO65141.1 - 0.021 14.0 0.6 0.021 14.0 0.6 1.8 2 0 0 2 2 2 0 Nucleotide-sugar transporter DUF423 PF04241.15 EFO65141.1 - 0.2 11.9 4.0 2 8.7 0.1 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF423) Glucosamine_iso PF01182.20 EFO65142.1 - 5.1e-27 95.2 0.0 9.1e-27 94.4 0.0 1.3 1 1 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Sugar-bind PF04198.13 EFO65142.1 - 0.008 15.3 0.1 0.45 9.6 0.1 2.6 2 1 0 2 2 2 2 Putative sugar-binding domain PfkB PF00294.24 EFO65143.1 - 5.7e-43 147.4 0.0 6.5e-43 147.1 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase NPV_P10 PF05531.12 EFO65145.1 - 3.2e-05 24.3 20.8 0.083 13.4 0.1 6.7 3 2 3 6 6 6 3 Nucleopolyhedrovirus P10 protein TMF_TATA_bd PF12325.8 EFO65145.1 - 0.00093 19.4 2.6 0.00093 19.4 2.6 5.3 2 2 2 5 5 5 2 TATA element modulatory factor 1 TATA binding T3SS_HrpK1 PF16937.5 EFO65145.1 - 0.022 14.4 1.6 1.7 8.2 0.1 3.2 3 0 0 3 3 3 0 Type III secretion system translocator protein, HrpF Phage_GP20 PF06810.11 EFO65145.1 - 0.085 12.7 24.5 1.1 9.0 0.1 5.3 2 1 3 5 5 5 0 Phage minor structural protein GP20 GIT_CC PF16559.5 EFO65145.1 - 1.2 9.1 13.2 4.6 7.2 0.2 5.8 5 1 1 6 6 6 0 GIT coiled-coil Rho guanine nucleotide exchange factor DHR10 PF18595.1 EFO65145.1 - 5.3 7.1 31.7 11 6.1 1.4 6.0 2 2 4 6 6 6 0 Designed helical repeat protein 10 domain PHM7_cyt PF14703.6 EFO65145.1 - 8.8 6.5 7.9 1.6 8.9 0.6 3.0 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter FUSC PF04632.12 EFO65145.1 - 9 4.7 12.4 1.9 6.9 1.2 2.5 2 1 0 2 2 2 0 Fusaric acid resistance protein family WD40 PF00400.32 EFO65148.1 - 2.3e-06 28.2 0.8 0.0038 18.0 0.0 3.9 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO65148.1 - 5.9e-06 26.5 0.0 0.098 13.0 0.0 3.5 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PSII_BNR PF14870.6 EFO65148.1 - 0.024 13.9 0.1 0.062 12.6 0.1 1.6 1 1 0 1 1 1 0 Photosynthesis system II assembly factor YCF48 WD40_like PF17005.5 EFO65148.1 - 0.024 13.9 0.6 0.47 9.7 0.1 2.7 2 1 0 3 3 3 0 WD40-like domain HmuY PF14064.6 EFO65148.1 - 0.074 13.3 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 HmuY protein PD40 PF07676.12 EFO65148.1 - 0.11 12.5 0.1 0.75 9.8 0.0 2.2 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 EFO65151.1 - 5.7e-06 27.0 2.7 10 7.2 0.3 5.1 4 0 0 4 4 4 4 WD domain, G-beta repeat ADK PF00406.22 EFO65152.1 - 6.5e-14 52.3 0.0 7.7e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EFO65152.1 - 2.2e-06 28.1 0.0 1.1e-05 25.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFO65152.1 - 0.0017 18.6 0.0 0.0026 17.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain ARPC4 PF05856.12 EFO65152.1 - 0.037 13.6 0.1 0.047 13.3 0.1 1.3 1 0 0 1 1 1 0 ARP2/3 complex 20 kDa subunit (ARPC4) AAA_18 PF13238.6 EFO65152.1 - 0.048 14.2 0.1 0.15 12.6 0.0 1.9 1 1 1 2 2 2 0 AAA domain NMDAR2_C PF10565.9 EFO65152.1 - 0.084 11.7 0.0 0.11 11.4 0.0 1.0 1 0 0 1 1 1 0 N-methyl D-aspartate receptor 2B3 C-terminus ResIII PF04851.15 EFO65154.1 - 1.2e-14 54.7 0.0 2.3e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFO65154.1 - 2.2e-06 28.0 0.2 6.3e-06 26.5 0.2 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFO65154.1 - 0.00018 21.3 0.0 0.00038 20.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C_2 PF13307.6 EFO65154.1 - 0.061 13.5 2.0 0.28 11.3 0.1 2.6 2 1 1 3 3 3 0 Helicase C-terminal domain YolD PF08863.10 EFO65155.1 - 0.073 13.1 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 YolD-like protein Mannosyl_trans PF05007.13 EFO65156.1 - 4.1e-25 89.1 11.5 1.1e-18 68.1 2.1 2.2 2 0 0 2 2 2 2 Mannosyltransferase (PIG-M) PIG-U PF06728.13 EFO65156.1 - 3.4e-09 36.2 8.4 3.4e-09 36.2 8.4 2.2 1 1 1 2 2 2 1 GPI transamidase subunit PIG-U GT87 PF09594.10 EFO65156.1 - 1.1e-07 31.8 6.9 1.1e-07 31.8 6.9 1.8 2 0 0 2 2 2 1 Glycosyltransferase family 87 Cation_efflux PF01545.21 EFO65157.1 - 1.5e-23 83.6 5.3 2e-23 83.2 5.3 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EFO65157.1 - 2.9e-06 27.3 0.5 6.6e-06 26.2 0.5 1.6 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter HMG_box PF00505.19 EFO65158.1 - 5.5e-07 29.9 4.2 5.5e-07 29.9 4.2 4.0 2 2 2 4 4 4 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFO65158.1 - 0.0043 17.6 2.8 0.0043 17.6 2.8 3.6 1 1 1 3 3 3 1 HMG-box domain Cnd1_N PF12922.7 EFO65158.1 - 0.0071 16.2 2.8 0.011 15.6 2.8 1.3 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term RR_TM4-6 PF06459.12 EFO65158.1 - 0.55 10.0 9.7 0.75 9.6 9.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Med19 PF10278.9 EFO65158.1 - 0.89 9.5 11.9 1.3 8.9 11.9 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Presenilin PF01080.17 EFO65158.1 - 3.2 6.4 5.4 3.5 6.3 5.4 1.1 1 0 0 1 1 1 0 Presenilin UQ_con PF00179.26 EFO65159.1 - 2.2e-14 53.3 0.0 4.4e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFO65159.1 - 0.08 13.2 0.5 0.22 11.8 0.0 2.0 2 0 0 2 2 2 0 RWD domain Alpha-E PF04168.12 EFO65159.1 - 0.3 10.8 0.1 0.3 10.8 0.1 1.9 3 0 0 3 3 3 0 A predicted alpha-helical domain with a conserved ER motif. Aminotran_5 PF00266.19 EFO65161.1 - 1.3e-26 93.5 0.0 1.7e-26 93.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V RCC_reductase PF06405.11 EFO65161.1 - 0.13 11.4 0.2 0.78 8.9 0.1 2.0 2 0 0 2 2 2 0 Red chlorophyll catabolite reductase (RCC reductase) MAP65_ASE1 PF03999.12 EFO65163.1 - 1.8e-10 40.2 19.9 4.2e-10 39.0 19.9 1.6 1 1 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) RSS_P20 PF11757.8 EFO65163.1 - 0.039 14.4 3.2 2.3 8.7 0.9 3.4 4 0 0 4 4 4 0 Suppressor of RNA silencing P21-like N-terminal domain Retro_M PF02813.14 EFO65163.1 - 0.067 13.6 0.0 0.19 12.2 0.0 1.8 1 0 0 1 1 1 0 Retroviral M domain AbiH PF14253.6 EFO65163.1 - 8.8 6.1 8.0 4.9 6.9 0.8 3.0 2 2 1 3 3 3 0 Bacteriophage abortive infection AbiH Sigma70_ner PF04546.13 EFO65163.1 - 9.4 6.1 10.6 0.53 10.1 0.1 3.0 2 2 1 3 3 3 0 Sigma-70, non-essential region DUF676 PF05057.14 EFO65165.1 - 5e-17 62.2 0.2 9.9e-17 61.2 0.2 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF915 PF06028.11 EFO65165.1 - 4.7e-05 22.8 0.0 0.00033 20.1 0.0 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Thioesterase PF00975.20 EFO65165.1 - 0.046 13.8 0.0 3.7 7.6 0.0 2.6 2 0 0 2 2 2 0 Thioesterase domain DUF900 PF05990.12 EFO65165.1 - 0.057 12.9 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.13 EFO65165.1 - 0.096 12.4 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein DUF726 PF05277.12 EFO65165.1 - 0.11 11.4 0.2 0.34 9.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF726) Herpes_UL55 PF04537.12 EFO65166.1 - 9.1e-05 22.5 0.1 0.00015 21.8 0.1 1.3 1 0 0 1 1 1 1 Herpesvirus UL55 protein PX PF00787.24 EFO65166.1 - 0.14 12.1 0.1 0.32 11.0 0.1 1.7 1 1 0 1 1 1 0 PX domain VSP PF03302.13 EFO65167.1 - 2.3e-75 253.9 163.6 3.2e-43 148.1 28.5 4.1 1 1 3 4 4 4 3 Giardia variant-specific surface protein BmKX PF09132.10 EFO65167.1 - 0.011 15.7 7.7 0.011 15.7 7.7 13.0 14 0 0 14 14 14 0 BmKX Ank_2 PF12796.7 EFO65168.1 - 4.1e-107 351.0 25.3 4.4e-16 59.3 0.2 9.0 1 1 8 9 9 9 8 Ankyrin repeats (3 copies) Ank PF00023.30 EFO65168.1 - 9e-67 218.8 22.2 3.4e-06 27.2 0.1 15.0 15 0 0 15 15 15 13 Ankyrin repeat Ank_4 PF13637.6 EFO65168.1 - 4e-66 218.6 22.5 2.3e-10 40.8 0.1 12.2 7 4 5 12 12 12 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65168.1 - 1.7e-63 203.0 15.1 0.00014 22.0 0.0 14.6 14 0 0 14 14 14 12 Ankyrin repeat Ank_5 PF13857.6 EFO65168.1 - 1e-59 197.8 32.6 5.2e-07 29.8 0.1 15.1 3 2 12 15 15 15 14 Ankyrin repeats (many copies) ERAP1_C PF11838.8 EFO65168.1 - 0.018 14.6 1.4 0.044 13.3 0.0 2.3 4 0 0 4 4 4 0 ERAP1-like C-terminal domain VSP PF03302.13 EFO65169.1 - 3.1e-197 655.2 194.6 8.1e-184 611.0 116.9 3.0 2 1 1 3 3 3 3 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO65169.1 - 0.025 14.7 0.8 0.3 11.2 0.1 2.7 2 0 0 2 2 2 0 Podoplanin Las1 PF04031.13 EFO65171.1 - 4.1e-33 114.7 0.1 8.1e-33 113.7 0.1 1.4 1 0 0 1 1 1 1 Las1-like AAA_6 PF12774.7 EFO65172.1 - 3.2e-138 460.2 0.2 3.4e-130 433.8 0.0 3.3 3 0 0 3 3 3 2 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFO65172.1 - 1e-106 357.4 4.2 1e-106 357.4 4.2 2.1 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 EFO65172.1 - 7.7e-87 291.4 0.0 1.4e-85 287.2 0.0 2.5 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 EFO65172.1 - 3.9e-46 157.5 1.1 2.7e-44 151.4 0.0 3.8 4 0 0 4 4 4 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 EFO65172.1 - 2.9e-44 150.8 1.7 1.4e-42 145.3 0.5 2.8 2 0 0 2 2 2 1 ATP-binding dynein motor region MT PF12777.7 EFO65172.1 - 5.1e-44 150.7 11.7 1.1e-43 149.7 11.7 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.7 EFO65172.1 - 1.6e-43 148.4 0.1 3.2e-41 140.8 0.0 3.6 3 0 0 3 3 3 1 P-loop containing dynein motor region Dynein_heavy PF03028.15 EFO65172.1 - 2.8e-33 114.5 0.0 1.2e-32 112.5 0.0 2.2 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 EFO65172.1 - 1.5e-28 99.7 0.2 1.4e-27 96.5 0.0 2.9 3 0 0 3 3 3 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 EFO65172.1 - 1.3e-12 47.8 0.0 4.5e-12 46.1 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFO65172.1 - 2.7e-12 46.9 0.0 0.0028 17.7 0.0 5.2 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 EFO65172.1 - 8.2e-10 38.9 0.0 6.5e-09 36.0 0.0 2.5 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_18 PF13238.6 EFO65172.1 - 1.6e-07 31.9 0.0 1.4 9.5 0.0 5.6 5 0 0 5 5 4 2 AAA domain AAA PF00004.29 EFO65172.1 - 1.1e-06 29.1 0.0 0.13 12.7 0.0 4.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFO65172.1 - 5.6e-06 26.8 5.2 0.34 11.3 0.1 5.7 4 1 1 5 5 5 1 AAA ATPase domain AAA_22 PF13401.6 EFO65172.1 - 2.6e-05 24.5 0.5 0.052 13.8 0.0 4.7 4 0 0 4 4 4 1 AAA domain AAA_29 PF13555.6 EFO65172.1 - 0.00053 19.7 3.1 0.47 10.2 0.5 3.7 3 0 0 3 3 3 1 P-loop containing region of AAA domain DHR10 PF18595.1 EFO65172.1 - 0.0011 19.0 6.8 0.0046 17.0 5.8 2.7 2 0 0 2 2 1 1 Designed helical repeat protein 10 domain APG6_N PF17675.1 EFO65172.1 - 0.0024 18.4 2.3 0.0024 18.4 2.3 4.2 4 0 0 4 4 2 1 Apg6 coiled-coil region AAA_30 PF13604.6 EFO65172.1 - 0.0054 16.5 0.5 1.9 8.1 0.0 3.0 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 EFO65172.1 - 0.016 14.9 0.1 0.68 9.6 0.1 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Cytidylate_kin PF02224.18 EFO65172.1 - 0.017 14.8 0.1 2.6 7.7 0.0 2.9 2 0 0 2 2 2 0 Cytidylate kinase RNA_helicase PF00910.22 EFO65172.1 - 0.09 13.2 0.1 45 4.5 0.0 3.8 3 0 0 3 3 3 0 RNA helicase RuvA_N PF01330.21 EFO65172.1 - 0.18 11.9 0.9 0.63 10.2 0.1 2.5 2 0 0 2 2 1 0 RuvA N terminal domain DUF3450 PF11932.8 EFO65172.1 - 0.28 10.5 8.3 17 4.6 5.9 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) UPF0242 PF06785.11 EFO65172.1 - 0.37 10.9 5.7 0.32 11.1 1.7 3.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus AAA_33 PF13671.6 EFO65172.1 - 0.63 10.2 2.5 4.2 7.5 0.1 3.3 3 0 0 3 3 2 0 AAA domain HrpB7 PF09486.10 EFO65172.1 - 0.82 10.0 21.5 0.21 12.0 3.7 4.0 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) TMF_DNA_bd PF12329.8 EFO65172.1 - 2 8.4 10.9 9.3 6.3 10.9 2.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF4201 PF13870.6 EFO65172.1 - 8.3 6.1 15.6 0.046 13.4 3.7 3.3 4 0 0 4 4 3 0 Domain of unknown function (DUF4201) Sin_N PF04801.13 EFO65173.1 - 7.5e-21 74.8 1.4 2.3e-14 53.5 0.1 2.2 2 0 0 2 2 2 2 Sin-like protein conserved region Pkinase PF00069.25 EFO65174.1 - 7.5e-29 100.9 0.0 2.5e-28 99.2 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EFO65174.1 - 5.6e-17 62.1 1.8 3.2e-13 50.0 0.1 2.8 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EFO65174.1 - 1.3e-15 57.4 0.0 1e-06 28.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Ank PF00023.30 EFO65174.1 - 2.1e-11 43.7 1.4 0.0028 18.0 0.0 3.9 3 1 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EFO65174.1 - 6.9e-10 39.3 0.6 4e-06 27.3 0.1 3.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65174.1 - 2.8e-09 36.4 2.9 0.023 15.2 0.1 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EFO65174.1 - 4.9e-08 33.1 1.1 2.1e-05 24.7 0.1 3.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) DUF2098 PF09871.9 EFO65174.1 - 0.026 14.8 0.0 0.062 13.6 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) Aa_trans PF01490.18 EFO65175.1 - 3e-27 95.4 37.5 2.8e-26 92.2 37.5 2.0 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Pribosyltran PF00156.27 EFO65176.1 - 1.1e-14 54.2 0.1 1.5e-14 53.8 0.1 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EFO65176.1 - 4.8e-05 22.9 0.0 6.9e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase CK_II_beta PF01214.18 EFO65179.1 - 5.8e-50 169.6 0.0 7.3e-50 169.3 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Ank_2 PF12796.7 EFO65180.1 - 2.2e-25 89.0 2.5 3.7e-08 33.8 0.1 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO65180.1 - 6.2e-13 48.7 4.7 0.0013 19.0 0.0 4.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO65180.1 - 1.3e-11 44.3 4.9 0.32 11.5 0.2 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 EFO65180.1 - 1.7e-11 44.4 3.6 0.0064 17.0 0.1 4.4 3 2 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65180.1 - 1e-08 34.7 4.3 5.3 7.9 0.0 5.7 5 0 0 5 5 5 3 Ankyrin repeat Pkinase PF00069.25 EFO65180.1 - 7e-07 28.9 0.0 2.8e-06 26.9 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65180.1 - 2e-05 24.0 0.0 3.6e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase VSP PF03302.13 EFO65181.1 - 5.8e-36 124.2 193.5 2.2e-21 76.2 70.2 7.3 1 1 3 4 4 4 3 Giardia variant-specific surface protein Ank_2 PF12796.7 EFO65183.1 - 3.7e-31 107.5 0.1 1.1e-12 48.4 0.0 5.1 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank PF00023.30 EFO65183.1 - 3.5e-20 71.5 0.1 0.00018 21.8 0.0 6.8 7 0 0 7 7 7 4 Ankyrin repeat Ank_4 PF13637.6 EFO65183.1 - 5.3e-17 61.9 0.1 6.6e-05 23.4 0.0 6.1 4 2 2 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO65183.1 - 1.9e-16 59.9 0.1 2.7e-06 27.5 0.0 5.3 3 1 2 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65183.1 - 1e-14 53.2 0.1 0.045 14.3 0.0 6.9 7 0 0 7 7 7 4 Ankyrin repeat Pkinase PF00069.25 EFO65183.1 - 0.0062 15.9 0.0 0.054 12.9 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Tma16 PF11176.8 EFO65185.1 - 5.2e-16 58.8 0.1 7.2e-16 58.4 0.1 1.2 1 0 0 1 1 1 1 Translation machinery-associated protein 16 zf-C3HC4_3 PF13920.6 EFO65186.1 - 1.7e-10 40.6 4.3 3.3e-10 39.7 4.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO65186.1 - 3.1e-08 33.3 3.6 6.2e-08 32.4 3.6 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFO65186.1 - 1.1e-05 25.7 6.0 1.1e-05 25.7 6.0 1.9 2 0 0 2 2 2 1 Ring finger domain Ank_2 PF12796.7 EFO65186.1 - 4.2e-05 24.0 0.4 0.00012 22.6 0.1 1.9 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO65186.1 - 0.00035 21.1 0.2 0.0013 19.3 0.1 2.0 2 0 0 2 2 1 1 Ankyrin repeats (many copies) zf-C3HC4_2 PF13923.6 EFO65186.1 - 0.00062 19.6 4.5 0.0016 18.3 4.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFO65186.1 - 0.0036 17.2 4.7 0.0081 16.1 4.7 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Ank_3 PF13606.6 EFO65186.1 - 0.0045 17.4 0.0 0.55 11.0 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EFO65186.1 - 0.012 15.9 0.3 0.045 14.1 0.0 2.1 2 0 0 2 2 2 0 Ankyrin repeats (many copies) zf-C3HC4 PF00097.25 EFO65186.1 - 0.023 14.6 4.7 0.023 14.6 4.7 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) RecR PF02132.15 EFO65186.1 - 0.058 13.0 3.8 3.4 7.3 0.3 2.6 2 0 0 2 2 2 0 RecR protein Ank PF00023.30 EFO65186.1 - 0.073 13.6 0.0 0.16 12.4 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeat zf-RING_11 PF17123.5 EFO65186.1 - 0.26 11.0 3.9 0.23 11.2 0.7 2.5 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_6 PF14835.6 EFO65186.1 - 0.28 11.1 6.8 0.067 13.1 3.1 1.8 2 0 0 2 2 2 0 zf-RING of BARD1-type protein ESCRT-II PF05871.12 EFO65187.1 - 9.9e-22 77.7 0.1 1.3e-21 77.4 0.1 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit Ribosomal_L19e PF01280.20 EFO65188.1 - 2.5e-55 186.5 11.1 2.5e-55 186.5 11.1 1.8 1 1 1 2 2 2 1 Ribosomal protein L19e Tup_N PF08581.10 EFO65191.1 - 0.0042 17.3 2.9 0.0042 17.3 2.9 2.6 1 1 1 2 2 2 1 Tup N-terminal TPR_MLP1_2 PF07926.12 EFO65191.1 - 0.0048 17.0 17.4 0.27 11.3 7.9 2.4 1 1 1 2 2 2 2 TPR/MLP1/MLP2-like protein SAS-6_N PF16531.5 EFO65191.1 - 0.0048 17.4 0.2 0.015 15.9 0.0 2.0 2 0 0 2 2 2 1 Centriolar protein SAS N-terminal ADIP PF11559.8 EFO65191.1 - 0.058 13.5 15.1 0.077 13.1 6.2 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.6 EFO65191.1 - 0.1 12.0 9.9 0.17 11.2 9.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 EFO65191.1 - 0.13 11.1 9.4 0.25 10.2 9.4 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Flagellin_N PF00669.20 EFO65191.1 - 0.75 9.9 14.1 0.03 14.4 6.4 2.5 2 1 1 3 3 3 0 Bacterial flagellin N-terminal helical region BBP1_C PF15272.6 EFO65191.1 - 1.8 8.3 10.0 7.7 6.3 9.6 2.1 1 1 1 2 2 2 0 Spindle pole body component BBP1, C-terminal Cortex-I_coil PF09304.10 EFO65191.1 - 3.6 7.9 17.8 0.76 10.0 8.2 2.5 1 1 1 2 2 2 0 Cortexillin I, coiled coil ABC_tran_CTD PF16326.5 EFO65191.1 - 6.7 7.0 18.7 1.8e+04 -6.3 18.7 3.7 1 1 0 1 1 1 0 ABC transporter C-terminal domain SET PF00856.28 EFO65192.1 - 1.1e-21 78.0 0.1 3.6e-21 76.3 0.1 1.8 1 1 0 1 1 1 1 SET domain YrzK PF17449.2 EFO65193.1 - 0.13 12.6 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized YrzK-like ABC_tran PF00005.27 EFO65194.1 - 1.7e-21 77.2 0.0 3e-21 76.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFO65194.1 - 1e-06 28.4 0.1 4.1e-06 26.4 0.1 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFO65194.1 - 1.1e-06 28.7 1.0 0.00043 20.2 0.2 2.7 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFO65194.1 - 0.00063 19.6 0.0 0.36 10.5 0.1 2.2 1 1 0 2 2 2 2 AAA ATPase domain G-alpha PF00503.20 EFO65194.1 - 0.026 13.7 0.0 0.049 12.8 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit AAA_29 PF13555.6 EFO65194.1 - 0.029 14.1 0.1 0.068 12.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSL PF05134.13 EFO65194.1 - 0.031 13.6 0.0 0.053 12.9 0.0 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein L AAA_23 PF13476.6 EFO65194.1 - 0.051 14.1 0.0 0.1 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFO65194.1 - 0.11 12.4 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase ASH PF15780.5 EFO65195.1 - 3.7e-08 33.5 2.1 5.3 7.3 0.0 7.6 7 1 0 7 7 7 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF1573 PF07610.11 EFO65195.1 - 0.00048 20.1 0.0 0.91 9.6 0.0 4.0 3 0 0 3 3 3 1 Protein of unknown function (DUF1573) Motile_Sperm PF00635.26 EFO65195.1 - 0.00091 19.1 6.4 5.2 7.0 0.0 7.5 9 0 0 9 9 9 1 MSP (Major sperm protein) domain VSP PF03302.13 EFO65196.1 - 1.8e-102 343.2 275.3 6.3e-75 252.5 83.4 8.0 1 1 6 7 7 7 6 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EFO65196.1 - 0.011 15.8 22.0 0.011 15.8 22.0 16.8 3 2 13 16 16 16 0 Furin-like repeat, cysteine-rich Acetyltransf_16 PF05301.11 EFO65197.1 - 3.2e-40 137.7 0.0 8.9e-40 136.3 0.0 1.6 2 0 0 2 2 2 1 GNAT acetyltransferase, Mec-17 Acetyltransf_7 PF13508.7 EFO65197.1 - 0.0021 18.4 0.0 0.0041 17.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFO65197.1 - 0.011 15.9 0.0 0.023 14.9 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Casein_kappa PF00997.18 EFO65197.1 - 0.032 14.3 0.6 0.05 13.7 0.1 1.6 2 0 0 2 2 2 0 Kappa casein FR47 PF08445.10 EFO65197.1 - 0.1 12.6 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_10 PF13673.7 EFO65197.1 - 0.11 12.5 0.0 0.56 10.1 0.0 2.1 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Pkinase PF00069.25 EFO65198.1 - 1.4e-25 90.1 0.0 2.2e-25 89.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65198.1 - 6e-20 71.6 0.0 3.1e-19 69.3 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO65198.1 - 0.036 13.4 0.0 0.098 12.0 0.0 1.6 1 1 0 1 1 1 0 Kinase-like Ank_2 PF12796.7 EFO65199.1 - 1.6e-23 83.1 0.1 1.1e-10 41.9 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO65199.1 - 8.5e-17 61.0 0.2 2e-06 27.9 0.0 4.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO65199.1 - 1.1e-14 54.5 0.0 2.1e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 EFO65199.1 - 8.5e-11 42.2 0.4 0.001 19.6 0.1 4.0 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFO65199.1 - 5.3e-10 39.3 0.0 0.021 15.3 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EFO65199.1 - 2.6e-09 36.5 0.1 1.2 9.9 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat Colicin_Pyocin PF01320.18 EFO65199.1 - 0.037 14.1 0.0 0.16 12.1 0.0 1.9 2 0 0 2 2 2 0 Colicin immunity protein / pyocin immunity protein DUF4883 PF16224.5 EFO65199.1 - 0.21 11.8 0.0 0.42 10.9 0.0 1.4 1 0 0 1 1 1 0 DOmain of unknown function (DUF4883) Ank_2 PF12796.7 EFO65200.1 - 1.4e-29 102.5 0.2 1.3e-10 41.7 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO65200.1 - 2.1e-18 66.4 2.2 3.5e-06 27.5 0.0 4.1 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO65200.1 - 5.7e-17 61.3 0.0 0.028 14.8 0.0 5.3 4 1 1 5 5 5 5 Ankyrin repeat Ank_3 PF13606.6 EFO65200.1 - 8.7e-15 53.4 0.4 0.015 15.8 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EFO65200.1 - 2.1e-13 50.2 0.3 0.0026 18.0 0.0 4.7 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFO65201.1 - 1.1e-24 86.8 0.0 8.8e-09 35.8 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO65201.1 - 4.7e-21 75.3 0.0 7.8e-21 74.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ank_5 PF13857.6 EFO65201.1 - 9.4e-21 73.6 0.1 1.8e-06 28.1 0.0 4.7 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO65201.1 - 1.7e-14 53.8 0.1 2.7e-13 49.8 0.1 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Ank_4 PF13637.6 EFO65201.1 - 1.3e-13 51.1 0.0 3.3e-05 24.4 0.0 4.9 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65201.1 - 5.2e-13 47.9 0.0 0.98 10.2 0.0 5.8 5 0 0 5 5 5 5 Ankyrin repeat Ank PF00023.30 EFO65201.1 - 2.9e-10 40.1 0.0 4.3 8.0 0.0 5.9 6 0 0 6 6 6 3 Ankyrin repeat Kinase-like PF14531.6 EFO65201.1 - 0.00015 21.2 0.0 0.00031 20.2 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Ank_2 PF12796.7 EFO65202.1 - 8.8e-49 164.0 10.2 1.2e-13 51.5 0.5 6.4 2 2 5 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO65202.1 - 3.8e-27 94.3 10.8 2.8e-06 27.8 0.2 7.7 7 2 3 10 10 10 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO65202.1 - 1.5e-26 91.6 16.7 0.0022 18.3 0.2 10.5 10 1 0 10 10 10 6 Ankyrin repeat Ank_5 PF13857.6 EFO65202.1 - 1e-25 89.4 15.2 5.1e-06 26.7 0.2 9.5 4 3 6 10 10 10 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65202.1 - 9.2e-24 80.9 13.9 0.035 14.6 0.0 11.1 12 0 0 12 12 12 6 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO65202.1 - 1.5e-09 37.6 15.6 3.7e-09 36.3 15.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO65202.1 - 2.6e-05 24.0 16.1 7.4e-05 22.5 16.1 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFO65202.1 - 0.2 11.7 15.0 0.52 10.3 15.0 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFO65202.1 - 0.23 11.5 13.2 0.23 11.5 10.4 2.3 1 1 1 2 2 2 0 RING-type zinc-finger Rer1 PF03248.13 EFO65203.1 - 7.3e-30 103.9 12.1 1.1e-29 103.3 11.8 1.5 1 1 0 1 1 1 1 Rer1 family Cpn60_TCP1 PF00118.24 EFO65204.1 - 4.5e-140 467.5 16.2 5.2e-140 467.3 16.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family HEPN_SAV2148 PF18725.1 EFO65204.1 - 0.24 10.8 2.1 1 8.7 0.2 2.3 2 0 0 2 2 2 0 SAV2148-like HEPN Mlf1IP PF10248.9 EFO65205.1 - 3.1e-08 33.8 13.1 9.5e-06 25.7 13.1 2.2 1 1 0 1 1 1 1 Myelodysplasia-myeloid leukemia factor 1-interacting protein Phage_Orf51 PF06194.11 EFO65205.1 - 0.056 13.5 0.0 1.5 8.9 0.0 2.3 2 0 0 2 2 2 0 Phage Conserved Open Reading Frame 51 Kinesin PF00225.23 EFO65206.1 - 2.1e-104 349.0 9.4 2.1e-104 349.0 9.4 2.7 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFO65206.1 - 1.5e-23 83.4 2.0 5.5e-23 81.6 0.9 2.5 2 1 0 2 2 2 1 Microtubule binding CENP-F_leu_zip PF10473.9 EFO65206.1 - 0.011 15.7 4.8 0.011 15.7 4.8 3.8 4 1 0 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GST_C_3 PF14497.6 EFO65206.1 - 0.021 15.0 0.0 0.15 12.3 0.0 2.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain STALD PF18185.1 EFO65206.1 - 0.025 14.0 0.4 0.5 9.7 0.1 2.5 2 0 0 2 2 2 0 Sir2- and TIR-associating SLOG family ArsR PF09824.9 EFO65206.1 - 0.13 11.8 1.5 0.83 9.2 1.5 2.4 1 0 0 1 1 1 0 ArsR transcriptional regulator Sipho_Gp157 PF05565.11 EFO65206.1 - 0.2 11.7 17.6 2.7 8.0 0.5 3.6 3 0 0 3 3 3 0 Siphovirus Gp157 DUF1192 PF06698.11 EFO65206.1 - 0.26 11.4 1.5 2.2 8.4 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Tup_N PF08581.10 EFO65206.1 - 2.1 8.7 10.8 2.3 8.6 4.1 4.0 4 0 0 4 4 4 0 Tup N-terminal Fib_alpha PF08702.10 EFO65206.1 - 2.5 8.3 16.8 2.5 8.3 4.8 4.9 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family Mt_ATP-synt_D PF05873.12 EFO65206.1 - 2.6 7.9 5.0 7.2 6.4 1.0 3.4 3 0 0 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) Kinesin_assoc PF16183.5 EFO65206.1 - 4.3 7.4 12.8 0.92 9.6 5.6 3.3 2 2 0 2 2 2 0 Kinesin-associated ADIP PF11559.8 EFO65206.1 - 4.6 7.3 13.2 3.3 7.8 4.8 4.1 4 1 0 4 4 4 0 Afadin- and alpha -actinin-Binding DUF4349 PF14257.6 EFO65206.1 - 4.8 6.6 12.2 0.18 11.2 0.9 3.8 5 0 0 5 5 5 0 Domain of unknown function (DUF4349) Laminin_II PF06009.12 EFO65206.1 - 8.1 6.5 21.4 6.1 6.9 5.2 5.1 3 2 0 4 4 4 0 Laminin Domain II ANAPC4_WD40 PF12894.7 EFO65208.1 - 4e-07 30.2 0.0 1.7e-05 25.0 0.0 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain TPR_19 PF14559.6 EFO65208.1 - 0.00037 21.0 7.6 2.4 8.7 0.1 5.1 5 1 1 6 6 6 3 Tetratricopeptide repeat Clathrin PF00637.20 EFO65208.1 - 0.14 12.0 0.3 6.4 6.7 0.1 2.9 3 0 0 3 3 3 0 Region in Clathrin and VPS TPR_12 PF13424.6 EFO65208.1 - 4.8 7.6 10.0 65 3.9 0.0 5.6 6 1 0 6 6 6 0 Tetratricopeptide repeat DUF1451 PF07295.11 EFO65208.1 - 6.5 6.8 9.6 69 3.4 0.1 3.4 3 0 0 3 3 3 0 Zinc-ribbon containing domain Ank_2 PF12796.7 EFO65209.1 - 4e-42 142.7 1.1 1.4e-13 51.2 0.3 3.8 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO65209.1 - 6.5e-30 103.1 1.5 4.1e-08 33.6 0.0 4.2 4 2 1 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO65209.1 - 1.1e-28 98.4 0.3 0.0003 21.1 0.0 7.2 7 0 0 7 7 7 6 Ankyrin repeat Ank_3 PF13606.6 EFO65209.1 - 9.3e-28 93.2 0.3 0.026 15.1 0.0 7.2 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 EFO65209.1 - 8.3e-23 80.2 7.0 2.2e-05 24.6 0.5 6.8 1 1 6 7 7 7 6 Ankyrin repeats (many copies) ASFV_360 PF01671.16 EFO65209.1 - 0.076 12.5 0.2 1.1 8.7 0.0 2.1 2 0 0 2 2 2 0 African swine fever virus multigene family 360 protein GDI PF00996.18 EFO65211.1 - 1.4e-150 501.7 0.0 2.4e-150 500.8 0.0 1.3 1 1 0 1 1 1 1 GDP dissociation inhibitor Ank_2 PF12796.7 EFO65212.1 - 6.7e-43 145.2 13.9 5e-14 52.6 0.7 6.5 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO65212.1 - 5.2e-22 77.9 7.0 3.6e-06 27.4 0.2 7.2 4 1 1 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO65212.1 - 1.1e-19 70.2 16.8 0.001 19.3 0.1 8.3 5 2 4 9 9 9 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65212.1 - 1.5e-16 58.8 12.9 0.3 11.8 0.1 9.8 9 1 0 9 9 9 4 Ankyrin repeat Ank PF00023.30 EFO65212.1 - 6.3e-13 48.5 16.7 0.031 14.7 0.7 9.1 8 2 0 8 8 8 4 Ankyrin repeat MSG PF02349.15 EFO65212.1 - 0.21 11.8 5.7 0.081 13.1 0.9 2.8 2 0 0 2 2 2 0 Major surface glycoprotein TolA_bind_tri PF16331.5 EFO65212.1 - 0.46 10.6 0.0 0.46 10.6 0.0 3.3 3 0 0 3 3 3 0 TolA binding protein trimerisation Cnn_1N PF07989.11 EFO65212.1 - 4.6 7.5 17.5 8.1 6.7 5.3 5.2 4 1 0 4 4 4 0 Centrosomin N-terminal motif 1 Sec7_N PF12783.7 EFO65214.1 - 0.026 14.4 0.3 0.14 12.1 0.1 2.3 2 0 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF3802 PF12290.8 EFO65215.1 - 0.008 16.7 5.3 0.21 12.1 1.9 2.8 2 1 0 2 2 2 1 Protein of unknown function (DUF3802) Cu PF17563.2 EFO65215.1 - 0.036 14.2 1.3 0.066 13.4 1.3 1.4 1 0 0 1 1 1 0 Cupiennin CelTOS PF18659.1 EFO65215.1 - 0.15 12.5 7.8 1.1 9.7 1.4 3.4 2 1 1 3 3 3 0 Cell-traversal protein for ookinetes and sporozoites DUF3552 PF12072.8 EFO65215.1 - 1.6 8.1 16.7 0.73 9.2 6.3 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF3552) DinB_2 PF12867.7 EFO65215.1 - 3.9 8.0 6.2 20 5.7 1.5 3.7 3 2 1 4 4 4 0 DinB superfamily RRP36 PF06102.12 EFO65215.1 - 8.2 6.4 10.1 8.5 6.3 1.6 2.8 2 1 0 2 2 2 0 rRNA biogenesis protein RRP36 Proteasome PF00227.26 EFO65216.1 - 1e-29 103.4 0.0 2e-29 102.4 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFO65216.1 - 1.8e-09 37.1 0.0 4.7e-09 35.7 0.0 1.8 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Cluap1 PF10234.9 EFO65217.1 - 2e-65 220.8 5.4 2e-65 220.8 5.4 1.5 2 0 0 2 2 2 1 Clusterin-associated protein-1 DUF3450 PF11932.8 EFO65217.1 - 0.002 17.5 5.1 0.0049 16.2 5.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) ZapB PF06005.12 EFO65217.1 - 0.011 16.2 3.5 0.011 16.2 3.5 2.9 3 0 0 3 3 2 0 Cell division protein ZapB DUF4407 PF14362.6 EFO65217.1 - 0.013 14.8 5.5 0.026 13.9 5.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3730 PF12530.8 EFO65217.1 - 0.077 12.5 2.7 0.12 11.9 2.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3730) Baculo_PEP_C PF04513.12 EFO65217.1 - 0.11 12.5 10.8 0.17 12.0 7.5 2.7 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus AKNA PF12443.8 EFO65217.1 - 0.14 12.8 7.4 0.12 13.0 2.7 2.4 2 0 0 2 2 2 0 AT-hook-containing transcription factor Ald_Xan_dh_C2 PF02738.18 EFO65217.1 - 0.29 9.5 3.0 0.42 9.0 3.0 1.1 1 0 0 1 1 1 0 Molybdopterin-binding domain of aldehyde dehydrogenase LOH1CR12 PF10158.9 EFO65217.1 - 1.3 9.1 7.0 1.4 9.0 4.0 2.3 2 1 0 2 2 2 0 Tumour suppressor protein ApoLp-III PF07464.11 EFO65217.1 - 1.9 8.6 13.5 0.75 9.9 7.9 2.8 2 1 1 3 3 2 0 Apolipophorin-III precursor (apoLp-III) DUF641 PF04859.12 EFO65217.1 - 1.9 8.8 15.4 2.5 8.5 7.8 3.2 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) DivIC PF04977.15 EFO65217.1 - 3.9 7.3 8.8 8.9 6.2 2.5 3.0 2 0 0 2 2 2 0 Septum formation initiator DUF1664 PF07889.12 EFO65217.1 - 4.9 7.2 7.0 6.9 6.7 3.9 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) FapA PF03961.13 EFO65217.1 - 5.3 5.5 7.3 7.9 5.0 4.5 1.6 1 1 1 2 2 2 0 Flagellar Assembly Protein A Phage_GPO PF05929.11 EFO65217.1 - 7.3 6.1 12.3 3.4 7.2 8.7 2.2 1 1 2 3 3 3 0 Phage capsid scaffolding protein (GPO) serine peptidase Atg14 PF10186.9 EFO65217.1 - 7.5 5.5 15.0 0.27 10.3 8.8 1.8 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 OmpH PF03938.14 EFO65217.1 - 7.5 6.9 21.0 4 7.8 8.5 2.9 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) Exonuc_VII_L PF02601.15 EFO65217.1 - 7.6 6.0 16.4 22 4.5 16.4 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit HAUS6_N PF14661.6 EFO65217.1 - 8.2 5.9 14.3 0.038 13.6 4.9 1.9 3 0 0 3 3 3 0 HAUS augmin-like complex subunit 6 N-terminus PGK PF00162.19 EFO65218.1 - 6.6e-145 482.8 0.0 7.5e-145 482.6 0.0 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase VSP PF03302.13 EFO65219.1 - 4.7e-76 256.2 112.9 2.7e-37 128.6 29.3 4.0 1 1 3 4 4 4 3 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO65219.1 - 0.024 14.8 0.0 0.054 13.6 0.0 1.6 1 0 0 1 1 1 0 Podoplanin SKG6 PF08693.10 EFO65219.1 - 0.28 10.6 4.5 0.47 9.9 4.5 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Acyltransferase PF01553.21 EFO65220.1 - 4.7e-10 39.2 0.0 9.3e-10 38.2 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase PP2C PF00481.21 EFO65221.1 - 1.4e-50 172.3 0.0 2.9e-50 171.3 0.0 1.4 2 0 0 2 2 2 1 Protein phosphatase 2C PP2C_2 PF13672.6 EFO65221.1 - 0.00014 21.6 0.0 0.00026 20.7 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C CDP-OH_P_transf PF01066.21 EFO65222.1 - 1.7e-12 47.9 0.6 1.7e-12 47.9 0.6 2.9 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Poty_PP PF08440.10 EFO65222.1 - 0.023 13.8 0.1 0.032 13.3 0.1 1.1 1 0 0 1 1 1 0 Potyviridae polyprotein DUF5549 PF17703.1 EFO65222.1 - 0.047 13.3 0.2 0.07 12.8 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5549) Aldo_ket_red PF00248.21 EFO65223.1 - 6.4e-51 173.3 0.0 7.6e-51 173.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family MORN PF02493.20 EFO65224.1 - 8.6e-70 226.7 83.5 6.3e-07 28.9 0.3 14.9 15 0 0 15 15 15 12 MORN repeat DUF3048_C PF17479.2 EFO65224.1 - 0.14 12.6 24.3 3.9 7.9 1.0 6.7 1 1 5 7 7 7 0 Protein of unknown function (DUF3048) C-terminal domain Peptidase_S55 PF05580.12 EFO65224.1 - 0.76 9.7 6.7 2.1 8.3 0.1 3.7 3 1 1 4 4 4 0 SpoIVB peptidase S55 CRM1_repeat_2 PF18784.1 EFO65225.1 - 6.7e-09 35.3 0.2 2.1e-08 33.7 0.2 1.8 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 IBN_N PF03810.19 EFO65225.1 - 1.1e-07 31.6 0.1 3.8e-07 29.9 0.1 2.0 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EFO65225.1 - 6e-06 26.4 2.2 6e-06 26.4 2.2 3.4 3 0 0 3 3 3 1 Exportin 1-like protein CLASP_N PF12348.8 EFO65226.1 - 0.012 15.1 7.4 3.2 7.3 0.2 5.6 6 1 1 7 7 7 0 CLASP N terminal RasGEF PF00617.19 EFO65226.1 - 0.19 11.9 5.4 4.1 7.6 0.2 3.2 2 1 0 3 3 3 0 RasGEF domain FGF PF00167.18 EFO65228.1 - 6.6e-05 23.0 0.0 9.7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.13 EFO65228.1 - 0.0019 18.4 0.0 0.23 11.7 0.0 2.1 1 1 1 2 2 2 2 Fascin domain Golgin_A5 PF09787.9 EFO65229.1 - 0.093 12.2 0.3 0.093 12.2 0.3 2.8 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF3584 PF12128.8 EFO65229.1 - 0.18 9.3 24.1 0.29 8.6 24.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ApoO PF09769.9 EFO65229.1 - 0.41 10.6 6.7 1.2 9.1 0.2 2.8 1 1 1 3 3 3 0 Apolipoprotein O Hormone_1 PF00103.20 EFO65229.1 - 3.2 7.4 7.5 5 6.8 6.3 1.9 1 1 1 2 2 2 0 Somatotropin hormone family DUF4407 PF14362.6 EFO65229.1 - 4.2 6.6 28.2 2.8e+02 0.6 28.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 EFO65229.1 - 7.7 6.6 29.5 6.1 6.9 8.4 3.8 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Ribonuc_L-PSP PF01042.21 EFO65233.1 - 1.3e-40 138.1 0.0 1.5e-40 137.9 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP E2F_TDP PF02319.20 EFO65234.1 - 1.3e-06 28.4 0.1 2.7e-06 27.3 0.1 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain Osmo_CC PF08946.10 EFO65234.1 - 0.048 13.9 0.2 0.11 12.8 0.2 1.5 1 0 0 1 1 1 0 Osmosensory transporter coiled coil Ribosomal_L29 PF00831.23 EFO65234.1 - 0.048 13.6 0.9 0.075 13.0 0.1 1.7 2 0 0 2 2 2 0 Ribosomal L29 protein TSC22 PF01166.18 EFO65234.1 - 0.058 13.7 0.1 0.25 11.7 0.0 1.9 2 0 0 2 2 2 0 TSC-22/dip/bun family ABC_tran_CTD PF16326.5 EFO65234.1 - 0.11 12.7 2.2 0.15 12.3 0.1 2.3 3 0 0 3 3 3 0 ABC transporter C-terminal domain DEAD PF00270.29 EFO65235.1 - 1.1e-13 51.4 0.0 1.6e-12 47.6 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFO65235.1 - 1e-10 42.0 0.0 3.5e-10 40.2 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HHH_5 PF14520.6 EFO65235.1 - 1.5e-07 31.9 0.0 4.7e-07 30.3 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain HemN_C PF06969.16 EFO65235.1 - 7.6e-05 22.7 0.0 0.0071 16.4 0.0 3.6 4 0 0 4 4 4 1 HemN C-terminal domain HHH PF00633.23 EFO65235.1 - 8.7e-05 22.2 0.0 0.00029 20.6 0.0 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix motif ResIII PF04851.15 EFO65235.1 - 0.00048 20.2 0.0 0.00082 19.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DNA_pol_lambd_f PF10391.9 EFO65235.1 - 0.002 17.9 0.0 0.0049 16.7 0.0 1.6 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda AAA_assoc_C PF09821.9 EFO65235.1 - 0.0021 18.6 0.0 0.026 15.1 0.0 2.4 2 0 0 2 2 2 1 C-terminal AAA-associated domain DUF4332 PF14229.6 EFO65235.1 - 0.1 12.8 0.2 0.53 10.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4332) HHH_2 PF12826.7 EFO65235.1 - 0.13 12.4 0.0 0.36 11.0 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Cdd1 PF11731.8 EFO65235.1 - 0.2 11.9 0.0 0.43 10.8 0.0 1.5 1 0 0 1 1 1 0 Pathogenicity locus Ank_2 PF12796.7 EFO65236.1 - 5.5e-108 353.8 27.8 4e-11 43.3 0.1 11.3 2 2 9 11 11 11 11 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO65236.1 - 6.7e-57 189.2 22.6 2.9e-05 24.5 0.0 16.0 9 4 8 17 17 17 16 Ankyrin repeats (many copies) Ank PF00023.30 EFO65236.1 - 5.9e-55 181.4 19.9 0.019 15.4 0.0 19.8 19 2 1 20 20 20 14 Ankyrin repeat Ank_3 PF13606.6 EFO65236.1 - 9.6e-55 176.1 22.7 0.036 14.6 0.0 20.3 20 0 0 20 20 20 14 Ankyrin repeat Ank_5 PF13857.6 EFO65236.1 - 2.6e-49 164.6 32.7 0.00015 22.0 0.0 17.8 4 4 16 20 20 20 14 Ankyrin repeats (many copies) zf-C3HC4_3 PF13920.6 EFO65236.1 - 1.5e-10 40.7 15.1 3.3e-10 39.7 15.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO65236.1 - 7.8e-06 25.7 13.3 1.7e-05 24.6 13.3 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFO65236.1 - 0.0021 18.3 11.5 0.0054 17.0 11.5 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EFO65236.1 - 0.025 14.6 9.8 0.057 13.4 9.8 1.7 1 0 0 1 1 1 0 zinc-RING finger domain ATG16 PF08614.11 EFO65237.1 - 4e-09 37.0 268.2 0.062 13.5 29.8 14.8 1 1 13 14 14 14 8 Autophagy protein 16 (ATG16) Fez1 PF06818.15 EFO65237.1 - 3e-06 27.8 198.9 0.00085 19.8 11.9 13.1 2 2 9 11 11 11 8 Fez1 Lebercilin PF15619.6 EFO65237.1 - 0.0013 18.4 6.2 0.0013 18.4 6.2 13.8 2 2 12 15 15 15 5 Ciliary protein causing Leber congenital amaurosis disease Spc7 PF08317.11 EFO65237.1 - 0.0033 16.4 12.8 0.0033 16.4 12.8 13.4 2 2 10 13 13 13 8 Spc7 kinetochore protein BST2 PF16716.5 EFO65237.1 - 0.0077 16.8 7.4 0.0077 16.8 7.4 19.3 7 5 13 22 22 22 4 Bone marrow stromal antigen 2 DUF5082 PF16888.5 EFO65237.1 - 0.01 16.1 6.2 0.01 16.1 6.2 16.2 4 4 10 17 17 17 0 Domain of unknown function (DUF5082) HMMR_N PF15905.5 EFO65237.1 - 0.59 9.6 191.1 0.044 13.2 19.0 10.5 2 2 6 10 10 10 0 Hyaluronan mediated motility receptor N-terminal GST_N_4 PF17172.4 EFO65237.1 - 0.88 10.4 5.8 32 5.4 0.3 4.3 3 0 0 3 3 3 0 Glutathione S-transferase N-terminal domain CLP1_P PF16575.5 EFO65239.1 - 3.1e-13 50.0 0.0 6.6e-13 48.9 0.0 1.5 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_16 PF13191.6 EFO65239.1 - 0.0085 16.5 0.0 0.017 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFO65239.1 - 0.013 15.8 0.0 0.03 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EFO65239.1 - 0.014 15.1 0.0 0.054 13.2 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 EFO65239.1 - 0.019 15.1 0.0 0.043 13.9 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_18 PF13238.6 EFO65239.1 - 0.041 14.4 0.0 0.08 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EFO65239.1 - 0.15 11.9 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_10 PF12846.7 EFO65239.1 - 0.2 10.5 0.0 0.3 9.9 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain PTH2 PF01981.16 EFO65240.1 - 2.1e-19 70.0 0.0 2.3e-19 69.8 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 APG6_N PF17675.1 EFO65241.1 - 1.4e-06 28.9 27.9 0.00015 22.3 8.6 3.1 2 1 1 3 3 3 2 Apg6 coiled-coil region Filament PF00038.21 EFO65241.1 - 0.00012 21.8 25.8 0.028 14.0 5.5 3.2 2 1 1 3 3 3 2 Intermediate filament protein Cep57_MT_bd PF06657.13 EFO65241.1 - 0.00019 21.8 1.8 0.00019 21.8 1.8 3.5 2 2 1 3 3 3 1 Centrosome microtubule-binding domain of Cep57 Spc7 PF08317.11 EFO65241.1 - 0.00098 18.1 25.3 0.0052 15.7 9.6 2.3 2 0 0 2 2 2 2 Spc7 kinetochore protein SOGA PF11365.8 EFO65241.1 - 0.0021 19.1 20.4 0.0091 17.1 5.4 3.5 2 2 1 3 3 3 1 Protein SOGA ATG16 PF08614.11 EFO65241.1 - 0.0038 17.5 30.9 0.078 13.2 5.4 3.2 2 1 0 2 2 2 1 Autophagy protein 16 (ATG16) KASH_CCD PF14662.6 EFO65241.1 - 0.0049 16.7 25.2 0.37 10.6 4.7 3.5 2 1 0 2 2 2 2 Coiled-coil region of CCDC155 or KASH YabA PF06156.13 EFO65241.1 - 0.0056 17.3 19.7 0.92 10.2 7.1 4.4 2 2 1 4 4 4 2 Initiation control protein YabA XLF PF09302.11 EFO65241.1 - 0.0059 16.8 1.1 0.0059 16.8 1.1 2.5 2 1 0 2 2 2 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component zf-C4H2 PF10146.9 EFO65241.1 - 0.0069 16.7 5.9 0.0069 16.7 5.9 2.1 2 0 0 2 2 2 1 Zinc finger-containing protein AAA_13 PF13166.6 EFO65241.1 - 0.0071 15.0 13.4 0.02 13.5 13.4 1.6 1 1 0 1 1 1 1 AAA domain Cnn_1N PF07989.11 EFO65241.1 - 0.0079 16.3 1.9 0.0079 16.3 1.9 4.6 2 2 2 4 4 4 1 Centrosomin N-terminal motif 1 bZIP_1 PF00170.21 EFO65241.1 - 0.0093 16.0 19.7 0.15 12.2 0.3 5.1 3 2 2 5 5 5 2 bZIP transcription factor Tropomyosin_1 PF12718.7 EFO65241.1 - 0.011 15.8 6.3 0.011 15.8 6.3 3.0 2 2 0 2 2 2 0 Tropomyosin like Fib_alpha PF08702.10 EFO65241.1 - 0.012 15.8 16.5 0.021 15.0 2.3 3.4 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Fez1 PF06818.15 EFO65241.1 - 0.013 16.0 21.9 0.074 13.5 4.3 3.1 1 1 1 2 2 2 0 Fez1 SlyX PF04102.12 EFO65241.1 - 0.014 16.0 0.2 0.014 16.0 0.2 5.5 2 2 3 5 5 5 0 SlyX ADIP PF11559.8 EFO65241.1 - 0.016 15.3 29.7 0.21 11.6 6.9 3.5 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding HAUS-augmin3 PF14932.6 EFO65241.1 - 0.044 13.4 24.3 0.019 14.5 4.3 3.3 2 1 1 3 3 3 0 HAUS augmin-like complex subunit 3 ABC_tran_CTD PF16326.5 EFO65241.1 - 0.051 13.8 0.8 0.051 13.8 0.8 4.8 3 2 2 5 5 4 0 ABC transporter C-terminal domain GAS PF13851.6 EFO65241.1 - 0.083 12.2 22.7 0.33 10.3 3.8 2.8 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding MAD PF05557.13 EFO65241.1 - 0.19 10.1 22.3 0.35 9.2 3.0 2.2 2 0 0 2 2 2 0 Mitotic checkpoint protein Cep57_CLD PF14073.6 EFO65241.1 - 0.2 11.6 27.2 0.046 13.7 13.6 2.5 2 1 0 2 2 2 0 Centrosome localisation domain of Cep57 Peptidase_U4 PF03419.13 EFO65241.1 - 0.21 10.8 0.0 0.47 9.7 0.0 1.5 1 0 0 1 1 1 0 Sporulation factor SpoIIGA TSC22 PF01166.18 EFO65241.1 - 0.23 11.8 17.8 0.69 10.3 1.6 4.8 2 1 1 3 3 3 0 TSC-22/dip/bun family UPF0242 PF06785.11 EFO65241.1 - 0.24 11.5 18.1 0.1 12.7 7.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TMF_TATA_bd PF12325.8 EFO65241.1 - 0.26 11.5 29.3 0.28 11.4 7.1 4.0 2 2 2 4 4 4 0 TATA element modulatory factor 1 TATA binding Effector_1 PF04518.12 EFO65241.1 - 0.29 10.2 9.9 0.038 13.1 2.8 2.7 2 2 0 2 2 2 0 Effector from type III secretion system ZapB PF06005.12 EFO65241.1 - 0.29 11.6 30.6 0.55 10.7 1.4 4.8 2 2 2 4 4 4 0 Cell division protein ZapB Laminin_I PF06008.14 EFO65241.1 - 0.32 10.7 25.4 1.1 8.9 3.0 3.1 2 1 1 3 3 3 0 Laminin Domain I DUF4472 PF14739.6 EFO65241.1 - 0.41 11.4 22.8 3.6 8.4 1.3 4.5 2 2 1 3 3 3 0 Domain of unknown function (DUF4472) DUF4201 PF13870.6 EFO65241.1 - 0.43 10.3 21.7 0.075 12.8 4.6 3.9 2 2 1 3 3 3 0 Domain of unknown function (DUF4201) Uso1_p115_C PF04871.13 EFO65241.1 - 0.49 10.8 25.0 0.24 11.8 5.7 3.6 2 1 2 4 4 4 0 Uso1 / p115 like vesicle tethering protein, C terminal region Jnk-SapK_ap_N PF09744.9 EFO65241.1 - 0.62 10.3 28.9 0.4 10.9 11.3 3.4 2 2 0 2 2 2 0 JNK_SAPK-associated protein-1 TPR_MLP1_2 PF07926.12 EFO65241.1 - 0.63 10.1 27.7 2.4 8.3 8.4 3.8 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein SPATA24 PF15175.6 EFO65241.1 - 0.71 9.7 9.4 0.11 12.4 1.2 2.7 2 1 0 2 2 2 0 Spermatogenesis-associated protein 24 Phlebovirus_NSM PF07246.11 EFO65241.1 - 0.8 9.0 9.5 0.091 12.1 3.3 2.2 2 0 0 2 2 2 0 Phlebovirus nonstructural protein NS-M DUF4315 PF14193.6 EFO65241.1 - 0.81 9.7 0.0 0.81 9.7 0.0 3.9 4 1 0 4 4 2 0 Domain of unknown function (DUF4315) CENP-F_leu_zip PF10473.9 EFO65241.1 - 0.98 9.4 31.3 1.5 8.9 5.4 3.4 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TEX13 PF15186.6 EFO65241.1 - 1 9.0 22.2 0.99 9.1 3.7 3.6 3 1 1 4 4 3 0 Testis-expressed sequence 13 protein family DUF5082 PF16888.5 EFO65241.1 - 1.6 9.0 17.0 3.4 7.9 0.6 4.3 2 2 1 3 3 3 0 Domain of unknown function (DUF5082) Atg14 PF10186.9 EFO65241.1 - 1.7 7.7 23.6 0.24 10.4 7.6 3.1 2 2 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 EFO65241.1 - 1.7 7.9 16.4 1 8.7 7.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF724 PF05266.14 EFO65241.1 - 2.1 8.1 18.4 0.094 12.5 2.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF724) Prominin PF05478.11 EFO65241.1 - 2.6 5.9 15.2 0.35 8.8 6.9 2.1 2 0 0 2 2 2 0 Prominin IL2 PF00715.17 EFO65241.1 - 2.6 8.0 7.8 0.83 9.6 3.0 2.6 2 1 0 2 2 2 0 Interleukin 2 SOAR PF16533.5 EFO65241.1 - 5.1 7.1 13.1 0.39 10.7 0.7 3.2 2 1 1 3 3 3 0 STIM1 Orai1-activating region HALZ PF02183.18 EFO65241.1 - 6.3 7.1 23.4 0.67 10.2 1.2 5.7 6 0 0 6 6 5 0 Homeobox associated leucine zipper Sec2p PF06428.11 EFO65241.1 - 6.5 6.8 22.3 6.8 6.7 3.1 4.8 2 2 2 4 4 4 0 GDP/GTP exchange factor Sec2p BLOC1_2 PF10046.9 EFO65241.1 - 6.5 7.1 12.4 0.42 10.9 3.3 3.3 3 2 1 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1635 PF07795.11 EFO65241.1 - 6.5 6.5 13.9 0.089 12.6 2.2 2.8 2 1 1 3 3 2 0 Protein of unknown function (DUF1635) Bacillus_HBL PF05791.11 EFO65241.1 - 7.1 6.4 12.2 4.2 7.1 1.4 3.2 2 2 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) PRKG1_interact PF15898.5 EFO65241.1 - 9.9 7.1 25.8 13 6.8 6.8 4.1 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain W2 PF02020.18 EFO65243.1 - 2.5e-12 46.8 0.6 1.3e-11 44.4 0.0 2.6 4 0 0 4 4 4 1 eIF4-gamma/eIF5/eIF2-epsilon Fib_alpha PF08702.10 EFO65243.1 - 0.046 13.9 3.3 0.11 12.7 3.3 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Sulphotransf PF09037.10 EFO65243.1 - 0.058 12.9 0.0 0.091 12.3 0.0 1.2 1 0 0 1 1 1 0 Stf0 sulphotransferase TraQ PF09679.10 EFO65243.1 - 0.092 12.7 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin chaperone (TraQ) zinc_ribbon_15 PF17032.5 EFO65243.1 - 0.31 11.8 2.5 12 6.8 0.0 2.8 1 1 1 2 2 2 0 zinc-ribbon family ERM PF00769.19 EFO65244.1 - 0.00031 20.6 0.5 0.00031 20.6 0.5 3.9 2 1 1 3 3 3 1 Ezrin/radixin/moesin family DUF5082 PF16888.5 EFO65244.1 - 0.0016 18.7 0.6 0.0016 18.7 0.6 6.5 3 2 2 5 5 5 2 Domain of unknown function (DUF5082) Fib_alpha PF08702.10 EFO65244.1 - 0.0069 16.6 10.3 0.0069 16.6 10.3 4.6 3 2 0 4 4 4 1 Fibrinogen alpha/beta chain family DUF1043 PF06295.12 EFO65244.1 - 0.022 14.8 1.5 0.022 14.8 1.5 4.0 4 1 0 4 4 4 0 Protein of unknown function (DUF1043) FlaC_arch PF05377.11 EFO65244.1 - 0.044 14.2 31.9 4.1 7.9 0.0 8.0 7 2 1 8 8 8 0 Flagella accessory protein C (FlaC) Fez1 PF06818.15 EFO65244.1 - 0.65 10.4 53.4 0.31 11.5 5.4 4.2 1 1 3 4 4 4 0 Fez1 Spc7 PF08317.11 EFO65244.1 - 0.66 8.8 56.0 1.1 8.0 11.1 4.2 3 1 1 4 4 4 0 Spc7 kinetochore protein DUF1664 PF07889.12 EFO65244.1 - 0.82 9.7 30.6 0.12 12.4 4.0 5.0 4 1 1 5 5 5 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 EFO65244.1 - 1.5 9.4 19.6 8.5 6.9 0.1 5.9 3 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein HMMR_N PF15905.5 EFO65244.1 - 2.9 7.3 51.8 3.9 6.9 15.5 4.1 3 1 1 4 4 4 0 Hyaluronan mediated motility receptor N-terminal PRKG1_interact PF15898.5 EFO65244.1 - 9.1 7.2 52.0 6.5 7.7 3.7 5.5 4 1 1 5 5 5 0 cGMP-dependent protein kinase interacting domain Ank_2 PF12796.7 EFO65246.1 - 8.9e-47 157.6 0.0 9.7e-18 64.6 0.0 4.6 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO65246.1 - 1.1e-34 118.3 1.6 2e-05 25.0 0.0 7.0 5 1 2 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 EFO65246.1 - 3.5e-33 112.6 0.0 0.00021 21.6 0.0 7.5 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 EFO65246.1 - 1.3e-30 105.0 3.7 1e-06 28.9 0.0 6.6 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65246.1 - 2.6e-22 76.5 0.3 0.047 14.2 0.0 7.9 7 0 0 7 7 7 4 Ankyrin repeat DUF1451 PF07295.11 EFO65246.1 - 0.0034 17.4 1.1 0.0034 17.4 1.1 2.6 3 0 0 3 3 2 1 Zinc-ribbon containing domain SPATA24 PF15175.6 EFO65246.1 - 0.0097 15.8 9.8 0.023 14.6 9.8 1.5 1 0 0 1 1 1 1 Spermatogenesis-associated protein 24 UPF0242 PF06785.11 EFO65246.1 - 0.024 14.7 13.7 1.1 9.3 10.3 2.5 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF1192 PF06698.11 EFO65246.1 - 0.034 14.2 6.5 0.25 11.4 0.5 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) Tropomyosin PF00261.20 EFO65246.1 - 0.055 12.8 13.4 0.082 12.3 9.8 2.3 1 1 1 2 2 2 0 Tropomyosin Zn-ribbon_8 PF09723.10 EFO65246.1 - 0.063 13.4 1.4 0.15 12.2 1.4 1.6 1 0 0 1 1 1 0 Zinc ribbon domain GAS PF13851.6 EFO65246.1 - 0.088 12.1 16.2 7.6 5.8 0.0 3.2 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding DZR PF12773.7 EFO65246.1 - 0.1 12.7 2.2 0.22 11.6 2.2 1.5 1 0 0 1 1 1 0 Double zinc ribbon DUF5401 PF17380.2 EFO65246.1 - 0.18 9.9 10.2 0.32 9.0 10.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5401) OrfB_Zn_ribbon PF07282.11 EFO65246.1 - 0.19 11.7 0.6 0.41 10.6 0.6 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-ribbon_3 PF13248.6 EFO65246.1 - 0.28 10.7 1.6 3.8 7.1 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain KASH_CCD PF14662.6 EFO65246.1 - 0.45 10.3 14.1 0.064 13.1 9.5 1.9 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH ZapB PF06005.12 EFO65246.1 - 0.49 10.9 18.6 0.47 10.9 7.0 4.8 3 1 1 4 4 4 0 Cell division protein ZapB DASH_Spc34 PF08657.10 EFO65246.1 - 0.62 9.8 12.3 1.1 9.0 7.3 2.7 3 0 0 3 3 3 0 DASH complex subunit Spc34 DUF4407 PF14362.6 EFO65246.1 - 0.7 9.2 12.6 0.096 12.0 5.8 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) Cytochrom_B562 PF07361.11 EFO65246.1 - 0.74 10.5 0.1 0.74 10.5 0.1 2.9 3 1 0 3 3 2 0 Cytochrome b562 DNA_RNApol_7kD PF03604.13 EFO65246.1 - 0.97 9.2 2.7 3.1 7.6 0.1 2.4 1 1 1 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit eIF-4B PF06273.11 EFO65246.1 - 1.4 7.9 4.8 2.3 7.2 4.8 1.3 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B DUF4061 PF13270.6 EFO65246.1 - 2 8.8 5.3 6.9 7.1 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4061) DUF3450 PF11932.8 EFO65246.1 - 2.2 7.5 9.2 1.9 7.8 5.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) TMF_TATA_bd PF12325.8 EFO65246.1 - 2.4 8.4 17.4 6.7 7.0 0.2 3.4 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding V_ATPase_I PF01496.19 EFO65246.1 - 3.6 5.4 6.6 0.48 8.3 2.6 1.4 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family IFT57 PF10498.9 EFO65246.1 - 4.7 6.1 12.5 2.9 6.8 7.6 2.6 2 1 1 3 3 3 0 Intra-flagellar transport protein 57 AAA_13 PF13166.6 EFO65246.1 - 4.8 5.7 10.5 0.4 9.3 5.6 1.6 2 0 0 2 2 2 0 AAA domain Spc7 PF08317.11 EFO65246.1 - 5.6 5.8 17.8 3.9 6.2 12.9 2.7 2 1 1 3 3 3 0 Spc7 kinetochore protein SlyX PF04102.12 EFO65246.1 - 6.8 7.4 18.0 1 10.1 0.2 4.6 4 1 1 5 5 4 0 SlyX Occludin_ELL PF07303.13 EFO65246.1 - 7.4 7.4 8.9 23 5.8 4.8 3.2 2 1 1 3 3 3 0 Occludin homology domain Pkinase PF00069.25 EFO65247.1 - 6.3e-17 61.8 0.0 8.1e-16 58.2 0.0 2.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65247.1 - 1.2e-06 28.0 0.0 2.2e-05 23.9 0.0 2.6 1 1 0 1 1 1 1 Protein tyrosine kinase DSPc PF00782.20 EFO65247.1 - 0.00026 20.8 0.0 0.00076 19.3 0.0 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Nup35_RRM PF05172.13 EFO65248.1 - 5.7e-06 26.2 0.0 1.6e-05 24.8 0.0 1.7 1 1 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 EFO65248.1 - 0.00024 21.0 0.0 0.00036 20.5 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Ank_2 PF12796.7 EFO65249.1 - 5.3e-15 55.8 0.4 1.2e-07 32.2 0.0 3.1 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFO65249.1 - 3.9e-07 30.2 1.8 0.59 10.7 0.0 5.0 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 EFO65249.1 - 2.3e-06 27.5 0.1 0.79 10.5 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EFO65249.1 - 2.9e-06 27.5 0.1 0.044 14.1 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO65249.1 - 0.00058 20.4 3.4 1.7 9.3 0.0 4.7 4 1 1 5 5 5 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFO65250.1 - 1.7e-89 294.5 6.7 2.3e-15 57.0 0.0 6.1 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank PF00023.30 EFO65250.1 - 1.3e-53 177.2 4.2 0.00017 21.9 0.0 11.8 12 0 0 12 12 12 9 Ankyrin repeat Ank_4 PF13637.6 EFO65250.1 - 7.4e-47 157.1 13.1 1.8e-07 31.6 0.1 9.8 4 3 6 10 10 10 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65250.1 - 2.8e-46 150.1 1.4 0.003 17.9 0.0 10.5 10 0 0 10 10 10 10 Ankyrin repeat Ank_5 PF13857.6 EFO65250.1 - 4.9e-39 131.9 22.6 8.7e-05 22.7 0.1 11.1 3 2 9 12 12 12 11 Ankyrin repeats (many copies) 3HCDH_RFF PF18321.1 EFO65250.1 - 0.011 16.1 0.5 97 3.5 0.0 4.9 5 0 0 5 5 5 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain KorB PF08535.10 EFO65250.1 - 0.13 12.3 0.0 0.32 11.1 0.0 1.7 1 0 0 1 1 1 0 KorB domain HCV_capsid PF01543.17 EFO65250.1 - 0.73 10.1 3.3 0.73 10.1 1.4 2.0 2 0 0 2 2 2 0 Hepatitis C virus capsid protein ARID PF01388.21 EFO65252.1 - 2.5e-05 24.8 0.1 9.5e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain GRIN_C PF15235.6 EFO65252.1 - 0.0043 17.3 0.0 0.0073 16.5 0.0 1.3 1 0 0 1 1 1 1 G protein-regulated inducer of neurite outgrowth C-terminus AAA_18 PF13238.6 EFO65253.1 - 3.3e-25 89.1 0.0 5.7e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EFO65253.1 - 4.7e-07 30.3 0.0 1.4e-06 28.7 0.0 1.7 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 EFO65253.1 - 5.9e-07 29.8 0.0 8e-06 26.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFO65253.1 - 0.00014 22.3 0.0 0.00026 21.4 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.15 EFO65253.1 - 0.00016 21.6 0.1 0.0017 18.3 0.0 2.1 2 0 0 2 2 2 1 NTPase AAA_24 PF13479.6 EFO65253.1 - 0.00031 20.5 0.0 0.0015 18.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EFO65253.1 - 0.00039 20.9 0.0 0.0022 18.4 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EFO65253.1 - 0.00087 19.6 0.0 0.002 18.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFO65253.1 - 0.0011 19.1 0.0 0.0023 18.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain Pneumo_M2 PF07380.11 EFO65253.1 - 0.0014 18.8 0.1 0.014 15.6 0.0 2.2 2 0 0 2 2 2 1 Pneumovirus M2 protein Mg_chelatase PF01078.21 EFO65253.1 - 0.0023 17.3 0.0 0.0037 16.7 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFO65253.1 - 0.0046 17.0 0.0 0.01 15.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ATPase PF06745.13 EFO65253.1 - 0.005 16.2 0.0 0.013 14.9 0.0 1.7 2 0 0 2 2 2 1 KaiC NACHT PF05729.12 EFO65253.1 - 0.0071 16.3 0.0 0.022 14.7 0.0 1.9 2 0 0 2 2 2 1 NACHT domain TniB PF05621.11 EFO65253.1 - 0.0094 15.4 0.0 0.029 13.8 0.0 1.8 2 0 0 2 2 2 1 Bacterial TniB protein AAA_14 PF13173.6 EFO65253.1 - 0.01 15.9 0.0 0.02 14.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain dNK PF01712.19 EFO65253.1 - 0.017 15.0 0.3 2.5 7.9 0.0 2.7 1 1 2 3 3 3 0 Deoxynucleoside kinase ATPase_2 PF01637.18 EFO65253.1 - 0.024 14.5 0.0 0.036 14.0 0.0 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Viral_helicase1 PF01443.18 EFO65253.1 - 0.033 13.9 0.1 0.13 11.9 0.0 1.9 1 1 1 2 2 2 0 Viral (Superfamily 1) RNA helicase Roc PF08477.13 EFO65253.1 - 0.035 14.3 0.0 0.07 13.4 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 EFO65253.1 - 0.055 12.6 0.0 0.15 11.2 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain GvpD PF07088.11 EFO65253.1 - 0.066 11.8 0.0 0.066 11.8 0.0 1.1 1 0 0 1 1 1 0 GvpD gas vesicle protein cobW PF02492.19 EFO65253.1 - 0.072 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain tRNA_lig_kinase PF08303.11 EFO65253.1 - 0.092 12.8 0.0 1.8 8.6 0.0 2.2 2 0 0 2 2 2 0 tRNA ligase kinase domain MeaB PF03308.16 EFO65253.1 - 0.11 11.5 0.0 0.19 10.7 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_7 PF12775.7 EFO65253.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_19 PF13245.6 EFO65253.1 - 0.13 12.6 0.1 0.51 10.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EFO65253.1 - 0.14 12.2 0.1 0.19 11.8 0.1 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase Parvo_NS1 PF01057.17 EFO65253.1 - 0.15 11.2 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Ank_2 PF12796.7 EFO65254.1 - 1e-67 224.7 8.0 3.9e-15 56.2 0.2 7.1 1 1 6 8 8 8 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO65254.1 - 2.3e-46 155.2 10.9 1.2e-09 38.3 0.1 10.7 4 3 7 11 11 11 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65254.1 - 1.1e-41 136.0 11.3 0.00095 19.5 0.0 13.6 15 0 0 15 15 15 8 Ankyrin repeat Ank PF00023.30 EFO65254.1 - 2.2e-41 138.6 7.3 9e-05 22.8 0.1 11.8 12 0 0 12 12 12 9 Ankyrin repeat Ank_4 PF13637.6 EFO65254.1 - 3.2e-37 126.4 2.4 9.8e-08 32.4 0.0 9.0 7 2 2 9 9 9 8 Ankyrin repeats (many copies) Cyclin_N PF00134.23 EFO65254.1 - 0.0075 16.0 0.7 13 5.6 0.0 4.9 4 1 1 5 5 5 1 Cyclin, N-terminal domain Pkinase PF00069.25 EFO65254.1 - 0.01 15.3 0.0 0.03 13.7 0.1 1.6 2 0 0 2 2 2 1 Protein kinase domain ANAPC4_WD40 PF12894.7 EFO65257.1 - 0.0063 16.8 0.0 0.47 10.8 0.0 3.3 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain IF4E PF01652.18 EFO65259.1 - 4.8e-13 49.2 0.0 7.3e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E PUF PF00806.19 EFO65260.1 - 6.5e-14 50.7 7.5 0.003 17.2 0.6 5.7 4 1 1 5 5 5 5 Pumilio-family RNA binding repeat MOZ_SAS PF01853.18 EFO65261.1 - 3.7e-51 173.3 0.1 2e-50 171.0 0.1 2.1 2 1 0 2 2 2 1 MOZ/SAS family zf-MYST PF17772.1 EFO65261.1 - 2.4e-18 65.5 3.6 5.2e-17 61.2 2.7 2.5 2 0 0 2 2 2 1 MYST family zinc finger domain Sgf11 PF08209.11 EFO65261.1 - 0.025 14.1 0.5 0.062 12.9 0.5 1.6 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) DUF2768 PF10966.8 EFO65261.1 - 0.17 12.3 0.0 0.42 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2768) Fez1 PF06818.15 EFO65262.1 - 2.4e-06 28.1 17.1 2.4e-06 28.1 17.1 8.9 2 2 6 8 8 8 2 Fez1 CALCOCO1 PF07888.11 EFO65262.1 - 7.3e-05 21.8 16.3 7.3e-05 21.8 16.3 6.9 3 3 3 6 6 6 2 Calcium binding and coiled-coil domain (CALCOCO1) like TACC_C PF05010.14 EFO65262.1 - 0.00026 20.8 3.0 0.00026 20.8 3.0 9.5 4 3 4 8 8 8 2 Transforming acidic coiled-coil-containing protein (TACC), C-terminal TPR_MLP1_2 PF07926.12 EFO65262.1 - 0.0037 17.3 9.0 0.0037 17.3 9.0 10.7 3 2 6 9 9 9 2 TPR/MLP1/MLP2-like protein TolA_bind_tri PF16331.5 EFO65262.1 - 0.0066 16.5 6.8 0.0066 16.5 6.8 11.6 9 3 3 13 13 13 2 TolA binding protein trimerisation HALZ PF02183.18 EFO65262.1 - 0.62 10.3 66.4 0.056 13.7 1.0 10.6 12 1 1 13 13 13 0 Homeobox associated leucine zipper Pox_A_type_inc PF04508.12 EFO65262.1 - 4.7 7.2 20.9 16 5.5 0.1 7.7 8 0 0 8 8 8 0 Viral A-type inclusion protein repeat Kinesin PF00225.23 EFO65264.1 - 1.7e-87 293.5 0.0 2.9e-87 292.7 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain DUF3972 PF13118.6 EFO65264.1 - 2.9e-22 79.4 0.5 6.1e-22 78.4 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3972) Microtub_bd PF16796.5 EFO65264.1 - 1.4e-17 64.0 0.0 4.2e-17 62.5 0.0 1.7 1 1 0 1 1 1 1 Microtubule binding Imm3 PF14425.6 EFO65264.1 - 0.028 14.5 0.0 0.16 12.0 0.0 2.2 2 0 0 2 2 2 0 Immunity protein Imm3 TSC22 PF01166.18 EFO65264.1 - 0.049 14.0 0.8 0.67 10.3 0.4 2.5 2 0 0 2 2 2 0 TSC-22/dip/bun family Lar_restr_allev PF14354.6 EFO65265.1 - 0.013 15.9 0.4 0.028 14.8 0.1 1.7 2 0 0 2 2 2 0 Restriction alleviation protein Lar Ogr_Delta PF04606.12 EFO65265.1 - 0.019 15.0 0.8 5.3 7.1 0.1 2.2 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger AMP-binding PF00501.28 EFO65266.1 - 9.2e-72 241.9 0.0 1.2e-71 241.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Pkinase PF00069.25 EFO65267.1 - 2.2e-22 79.7 0.0 4.1e-22 78.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65267.1 - 2.1e-12 46.9 0.0 4.5e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase 2OG-Fe_Oxy_2 PF10014.9 EFO65267.1 - 0.081 12.7 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe dioxygenase Lzipper-MIP1 PF14389.6 EFO65267.1 - 0.19 12.1 2.4 6.9 7.0 0.2 2.8 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 CENP-F_leu_zip PF10473.9 EFO65267.1 - 0.49 10.4 3.4 1.6 8.7 0.4 2.5 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EAV_GP5 PF15981.5 EFO65268.1 - 0.02 15.3 0.0 0.059 13.8 0.0 1.9 1 0 0 1 1 1 0 Envelope glycoprotein GP 5 of equine arteritis virus zf-HC3 PF16827.5 EFO65269.1 - 0.024 14.8 0.4 7.7 6.8 0.0 2.5 2 0 0 2 2 2 0 zinc-finger Dynein_light PF01221.18 EFO65270.1 - 4e-40 136.0 1.3 4.4e-40 135.9 1.3 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Phage_Gp111 PF07410.11 EFO65270.1 - 0.063 13.8 0.2 0.067 13.7 0.2 1.1 1 0 0 1 1 1 0 Streptococcus thermophilus bacteriophage Gp111 protein Ectatomin PF06457.11 EFO65270.1 - 0.15 12.0 0.2 0.26 11.2 0.2 1.4 1 0 0 1 1 1 0 Ectatomin Sigma70_r2 PF04542.14 EFO65270.1 - 0.16 11.8 0.0 0.69 9.7 0.0 1.9 2 0 0 2 2 2 0 Sigma-70 region 2 zf-RING_6 PF14835.6 EFO65271.1 - 2.7e-08 33.6 4.9 8.4e-08 32.0 4.9 1.8 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 EFO65271.1 - 7e-08 32.5 7.7 1.3e-07 31.7 7.7 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EFO65271.1 - 4.3e-07 29.7 5.2 9.3e-07 28.6 5.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFO65271.1 - 4.1e-06 26.6 6.7 8e-06 25.6 6.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO65271.1 - 4.4e-06 26.4 6.9 8e-06 25.6 6.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFO65271.1 - 5.4e-06 26.3 5.3 1.1e-05 25.3 5.3 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFO65271.1 - 2.9e-05 24.0 3.6 2.9e-05 24.0 3.6 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EFO65271.1 - 0.00033 20.9 7.8 0.00072 19.8 7.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFO65271.1 - 0.0065 16.3 10.1 0.0065 16.3 10.1 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_14 PF17978.1 EFO65271.1 - 0.025 15.0 1.9 0.045 14.2 1.9 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DZR PF12773.7 EFO65271.1 - 0.26 11.3 3.7 1.3 9.2 3.9 2.1 1 1 1 2 2 2 0 Double zinc ribbon zf-rbx1 PF12678.7 EFO65271.1 - 0.29 11.5 5.0 0.78 10.1 5.0 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_10 PF16685.5 EFO65271.1 - 0.46 10.7 5.7 1 9.5 5.7 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 AbbA_antirepres PF14156.6 EFO65272.1 - 0.095 12.6 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Antirepressor AbbA AAA_8 PF12780.7 EFO65273.1 - 1e-99 333.1 0.0 6.3e-98 327.2 0.0 3.4 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 EFO65273.1 - 2.9e-92 309.2 0.0 2.9e-92 309.2 0.0 2.5 3 0 0 3 3 3 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 EFO65273.1 - 7e-82 273.8 1.5 7e-82 273.8 1.5 2.9 3 0 0 3 3 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 EFO65273.1 - 5.6e-55 185.7 0.2 9.3e-54 181.7 0.0 2.8 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_6 PF12774.7 EFO65273.1 - 8.1e-54 182.8 0.0 3.9e-53 180.5 0.0 2.2 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region MT PF12777.7 EFO65273.1 - 3.7e-52 177.5 8.5 7.7e-52 176.4 8.5 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 EFO65273.1 - 1.3e-48 164.9 0.0 2.6e-48 163.9 0.0 1.5 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 EFO65273.1 - 8.5e-33 113.0 0.3 1.7e-30 105.5 0.0 3.7 3 1 0 3 3 2 1 Dynein heavy chain region D6 P-loop domain AAA_lid_1 PF17857.1 EFO65273.1 - 4.4e-17 62.1 0.0 1.8e-16 60.2 0.0 2.1 1 0 0 1 1 1 1 AAA+ lid domain Dynein_AAA_lid PF17852.1 EFO65273.1 - 7.3e-11 42.3 0.2 3.3e-10 40.1 0.2 2.3 1 1 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 EFO65273.1 - 2.2e-10 40.7 0.0 0.00015 21.8 0.0 3.8 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFO65273.1 - 3.7e-05 24.0 0.0 0.24 11.7 0.0 4.0 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 EFO65273.1 - 0.0018 18.7 0.2 3.6 8.0 0.0 4.2 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) Septin PF00735.18 EFO65273.1 - 0.014 14.7 0.0 0.058 12.7 0.0 2.0 1 0 0 1 1 1 0 Septin AAA_14 PF13173.6 EFO65273.1 - 0.027 14.5 0.0 0.13 12.3 0.0 2.2 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EFO65273.1 - 0.038 13.7 0.2 0.31 10.7 0.0 2.6 3 0 0 3 3 2 0 Sigma-54 interaction domain Pox_A32 PF04665.12 EFO65273.1 - 0.043 13.3 0.0 0.13 11.7 0.0 1.8 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_16 PF13191.6 EFO65273.1 - 0.047 14.1 2.7 3.5 8.0 0.0 4.4 5 0 0 5 5 4 0 AAA ATPase domain Sigma54_activ_2 PF14532.6 EFO65273.1 - 0.07 13.2 0.5 1 9.5 0.0 3.0 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_29 PF13555.6 EFO65273.1 - 0.099 12.4 0.3 8.4 6.2 0.0 3.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain Roc PF08477.13 EFO65273.1 - 0.11 12.7 0.0 0.92 9.7 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 EFO65273.1 - 0.19 11.4 0.8 1.4 8.6 0.0 2.8 3 0 0 3 3 3 0 AAA domain Myosin_tail_1 PF01576.19 EFO65273.1 - 3.3 5.4 37.9 0.0036 15.2 10.9 3.1 3 0 0 3 3 3 0 Myosin tail DUF4407 PF14362.6 EFO65273.1 - 5.9 6.2 23.4 0.66 9.3 2.4 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) SOAR PF16533.5 EFO65273.1 - 6.7 6.7 14.9 0.043 13.8 4.5 2.9 2 1 0 2 2 1 0 STIM1 Orai1-activating region ERM PF00769.19 EFO65273.1 - 8.3 6.1 41.6 2.2 8.0 15.0 3.3 3 0 0 3 3 3 0 Ezrin/radixin/moesin family DUF4618 PF15397.6 EFO65274.1 - 0.00064 19.2 9.9 0.0011 18.4 1.9 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF4618) TMF_DNA_bd PF12329.8 EFO65274.1 - 0.00095 19.1 11.0 0.2 11.7 1.8 3.0 1 1 0 2 2 2 2 TATA element modulatory factor 1 DNA binding DUF641 PF04859.12 EFO65274.1 - 0.0011 19.3 9.9 0.086 13.2 0.8 2.3 1 1 1 2 2 2 2 Plant protein of unknown function (DUF641) TMF_TATA_bd PF12325.8 EFO65274.1 - 0.0015 18.8 14.2 0.079 13.2 0.9 2.1 1 1 1 2 2 2 2 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 EFO65274.1 - 0.0019 17.2 9.4 0.0024 16.8 9.4 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein PKcGMP_CC PF16808.5 EFO65274.1 - 0.002 17.9 1.5 0.002 17.9 1.5 2.9 3 0 0 3 3 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase APG6_N PF17675.1 EFO65274.1 - 0.0043 17.6 7.8 0.0043 17.6 7.8 1.6 1 1 1 2 2 2 1 Apg6 coiled-coil region Csm1_N PF18504.1 EFO65274.1 - 0.0047 17.2 11.9 0.0079 16.5 2.6 2.9 1 1 2 3 3 3 1 Csm1 N-terminal domain HrpB2 PF09487.10 EFO65274.1 - 0.0062 16.9 2.1 0.0086 16.5 2.1 1.3 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB2) CREPT PF16566.5 EFO65274.1 - 0.0066 16.6 8.6 0.0079 16.4 8.6 1.1 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour Fez1 PF06818.15 EFO65274.1 - 0.0069 16.9 7.4 0.0088 16.5 7.4 1.1 1 0 0 1 1 1 1 Fez1 CEP63 PF17045.5 EFO65274.1 - 0.012 15.6 11.5 0.11 12.3 2.1 2.1 1 1 1 2 2 2 0 Centrosomal protein of 63 kDa DIT1_PvcA PF05141.12 EFO65274.1 - 0.012 15.1 0.5 0.016 14.7 0.5 1.2 1 1 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein HMMR_N PF15905.5 EFO65274.1 - 0.016 14.7 10.7 0.099 12.1 10.7 1.8 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Syntaxin_2 PF14523.6 EFO65274.1 - 0.019 15.3 5.4 0.05 14.0 5.4 1.7 1 1 0 1 1 1 0 Syntaxin-like protein TPR_MLP1_2 PF07926.12 EFO65274.1 - 0.027 14.6 10.6 0.024 14.7 9.6 1.5 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.10 EFO65274.1 - 0.027 14.7 7.5 0.06 13.5 7.4 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family BST2 PF16716.5 EFO65274.1 - 0.032 14.8 7.2 2.6 8.7 3.4 2.5 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF3972 PF13118.6 EFO65274.1 - 0.038 14.4 7.9 0.86 10.1 1.1 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3972) CC2-LZ PF16516.5 EFO65274.1 - 0.042 14.2 9.1 0.21 12.0 1.9 2.4 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF4407 PF14362.6 EFO65274.1 - 0.052 12.9 4.9 0.06 12.7 4.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SPATA6 PF14909.6 EFO65274.1 - 0.059 13.5 0.4 0.1 12.7 0.2 1.5 1 1 0 1 1 1 0 Spermatogenesis-assoc protein 6 DivIC PF04977.15 EFO65274.1 - 0.068 12.9 11.3 0.5 10.2 1.9 2.9 1 1 2 3 3 3 0 Septum formation initiator YkyA PF10368.9 EFO65274.1 - 0.071 12.8 7.4 0.1 12.3 7.4 1.3 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein HIP1_clath_bdg PF16515.5 EFO65274.1 - 0.075 13.7 11.7 0.12 13.0 9.9 1.9 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Sec8_exocyst PF04048.14 EFO65274.1 - 0.077 12.9 3.9 0.1 12.5 0.3 2.1 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain Lectin_N PF03954.14 EFO65274.1 - 0.093 12.5 3.7 0.37 10.5 3.7 1.9 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain DUF3251 PF11622.8 EFO65274.1 - 0.11 12.2 6.1 1.6 8.3 0.2 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF3251) Prefoldin_2 PF01920.20 EFO65274.1 - 0.12 12.4 12.2 6.2 6.8 12.2 2.5 1 1 0 1 1 1 0 Prefoldin subunit UPF0242 PF06785.11 EFO65274.1 - 0.13 12.4 10.1 0.38 10.8 10.1 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Seryl_tRNA_N PF02403.22 EFO65274.1 - 0.13 12.5 8.5 0.61 10.3 0.6 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FAM76 PF16046.5 EFO65274.1 - 0.14 11.5 7.8 1.4 8.2 1.6 2.0 1 1 1 2 2 2 0 FAM76 protein Bacillus_HBL PF05791.11 EFO65274.1 - 0.15 11.9 4.4 0.67 9.8 4.4 1.9 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) ADIP PF11559.8 EFO65274.1 - 0.18 11.9 9.9 0.43 10.7 9.0 1.9 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding Atg14 PF10186.9 EFO65274.1 - 0.19 10.8 7.4 0.21 10.6 7.4 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 XLF PF09302.11 EFO65274.1 - 0.2 11.8 3.7 0.17 12.0 1.4 1.8 1 1 1 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component HR1 PF02185.16 EFO65274.1 - 0.22 11.6 14.4 8.7 6.5 6.3 3.7 1 1 2 3 3 3 0 Hr1 repeat MPS2 PF17060.5 EFO65274.1 - 0.22 10.7 5.0 0.28 10.4 5.0 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 NPV_P10 PF05531.12 EFO65274.1 - 0.23 12.0 6.2 0.72 10.4 2.8 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein FliD_N PF02465.18 EFO65274.1 - 0.25 12.1 6.4 0.72 10.6 2.1 2.1 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Pil1 PF13805.6 EFO65274.1 - 0.32 10.4 9.1 0.4 10.1 9.1 1.3 1 1 0 1 1 1 0 Eisosome component PIL1 FlaC_arch PF05377.11 EFO65274.1 - 0.45 11.0 6.4 4.9 7.6 0.2 2.5 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Exonuc_VII_L PF02601.15 EFO65274.1 - 0.55 9.7 7.0 0.64 9.5 7.0 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spc24 PF08286.11 EFO65274.1 - 0.58 10.4 10.5 1.1 9.6 1.5 2.7 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 SlyX PF04102.12 EFO65274.1 - 0.61 10.7 12.1 2.2 9.0 2.0 3.1 1 1 2 3 3 3 0 SlyX AAA_13 PF13166.6 EFO65274.1 - 0.81 8.3 8.5 0.45 9.1 1.6 1.6 1 1 1 2 2 2 0 AAA domain DivIVA PF05103.13 EFO65274.1 - 0.93 9.6 11.5 1.9 8.5 11.5 1.4 1 1 0 1 1 1 0 DivIVA protein YabA PF06156.13 EFO65274.1 - 1.2 9.9 8.4 3.3 8.4 2.1 2.3 1 1 1 2 2 2 0 Initiation control protein YabA CENP-H PF05837.12 EFO65274.1 - 1.4 9.4 11.7 2 8.8 5.0 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Cnn_1N PF07989.11 EFO65274.1 - 1.4 9.2 10.6 28 5.0 2.8 3.0 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 DUF1664 PF07889.12 EFO65274.1 - 1.4 8.9 7.1 1 9.4 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) LMBR1 PF04791.16 EFO65274.1 - 1.6 7.5 3.9 1.7 7.4 3.9 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein HAUS6_N PF14661.6 EFO65274.1 - 1.6 8.2 7.4 2.8 7.4 7.4 1.4 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF724 PF05266.14 EFO65274.1 - 1.7 8.4 9.0 8.6 6.1 9.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF724) COG2 PF06148.11 EFO65274.1 - 2 8.5 8.1 1.5 8.9 2.5 2.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4094 PF13334.6 EFO65274.1 - 2.7 8.5 8.1 9.5 6.7 1.8 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) DUF4140 PF13600.6 EFO65274.1 - 4.3 7.9 9.4 6.6 7.2 3.7 2.3 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) zf-C4H2 PF10146.9 EFO65274.1 - 9.1 6.5 9.2 11 6.3 9.2 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein Mcm10 PF09332.11 EFO65276.1 - 3.4e-05 23.4 4.5 4.8e-05 22.9 4.5 1.3 1 0 0 1 1 1 1 Mcm10 replication factor zf-primase PF09329.11 EFO65276.1 - 5.1e-05 23.0 0.0 0.00017 21.3 0.0 1.9 1 0 0 1 1 1 1 Primase zinc finger DnaJ_CXXCXGXG PF00684.19 EFO65276.1 - 0.21 12.0 6.0 0.49 10.8 6.0 1.6 1 0 0 1 1 1 0 DnaJ central domain CCDC-167 PF15188.6 EFO65277.1 - 0.033 14.5 1.4 0.033 14.5 1.4 3.8 3 1 0 3 3 3 0 Coiled-coil domain-containing protein 167 Mating_N PF12731.7 EFO65277.1 - 0.11 12.6 1.1 0.33 11.1 0.4 2.2 2 1 0 2 2 2 0 Mating-type protein beta 1 DivIC PF04977.15 EFO65277.1 - 0.24 11.2 21.4 0.93 9.3 3.2 4.4 4 2 0 4 4 4 0 Septum formation initiator PI3K_P85_iSH2 PF16454.5 EFO65277.1 - 1 8.9 12.4 26 4.3 11.3 3.0 2 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF1269 PF06897.12 EFO65277.1 - 1.5 9.2 3.0 1.5 9.2 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) DUF1319 PF07028.11 EFO65277.1 - 4.2 7.6 13.6 0.71 10.1 1.8 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1319) DUF5320 PF17253.2 EFO65277.1 - 4.8 8.3 10.7 35 5.6 0.0 4.4 4 1 0 4 4 4 0 Family of unknown function (DUF5320) SlyX PF04102.12 EFO65277.1 - 6.9 7.4 21.7 2.6 8.7 0.7 5.5 4 2 2 6 6 6 0 SlyX DUF4407 PF14362.6 EFO65277.1 - 7.5 5.8 17.8 7 5.9 8.6 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Cas_Cmr5 PF09701.10 EFO65278.1 - 0.0014 18.9 0.6 0.0029 17.9 0.2 1.7 2 0 0 2 2 2 1 CRISPR-associated protein (Cas_Cmr5) Ank_2 PF12796.7 EFO65279.1 - 7e-121 395.1 30.2 6.1e-17 62.0 0.0 7.6 1 1 9 10 10 10 10 Ankyrin repeats (3 copies) Ank PF00023.30 EFO65279.1 - 1.4e-66 218.2 14.4 0.00029 21.1 0.0 14.2 15 0 0 15 15 15 13 Ankyrin repeat Ank_3 PF13606.6 EFO65279.1 - 1.5e-55 178.6 14.2 0.0036 17.7 0.0 13.5 13 0 0 13 13 13 13 Ankyrin repeat Ank_4 PF13637.6 EFO65279.1 - 9.1e-55 182.4 20.9 1.9e-07 31.5 0.2 11.2 6 4 8 14 14 14 13 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO65279.1 - 4.4e-51 170.3 34.2 1.9e-07 31.2 0.5 13.5 2 1 13 15 15 15 13 Ankyrin repeats (many copies) Tox-PL-2 PF15643.6 EFO65279.1 - 0.062 13.4 0.1 7.4 6.8 0.0 2.8 1 1 1 2 2 2 0 Papain fold toxin 2 PP2C PF00481.21 EFO65279.1 - 0.12 12.0 0.1 8.7 5.9 0.0 2.8 3 0 0 3 3 3 0 Protein phosphatase 2C DUF3568 PF12092.8 EFO65279.1 - 0.14 12.2 0.0 0.45 10.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3568) Ank_2 PF12796.7 EFO65280.1 - 8.2e-59 196.2 0.5 1.3e-15 57.7 0.1 4.1 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EFO65280.1 - 2.6e-42 141.4 0.3 0.00011 22.4 0.0 7.7 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 EFO65280.1 - 6.2e-38 128.4 8.1 1.3e-05 25.3 0.0 7.6 2 1 6 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65280.1 - 2.5e-35 116.5 0.1 0.00029 21.0 0.0 7.6 8 0 0 8 8 8 6 Ankyrin repeat Ank_4 PF13637.6 EFO65280.1 - 3.7e-35 119.8 0.6 2.1e-08 34.5 0.0 5.4 5 1 0 5 5 5 4 Ankyrin repeats (many copies) PHD PF00628.29 EFO65280.1 - 0.019 14.8 0.2 22 5.0 0.0 3.7 4 0 0 4 4 4 0 PHD-finger 3HCDH_RFF PF18321.1 EFO65280.1 - 0.021 15.3 1.3 2e+02 2.5 0.0 5.4 6 1 0 6 6 6 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain ERAP1_C PF11838.8 EFO65280.1 - 0.2 11.2 0.6 14 5.1 0.0 3.4 1 1 1 3 3 3 0 ERAP1-like C-terminal domain SprT-like PF10263.9 EFO65281.1 - 3.8e-25 87.9 0.3 5.8e-25 87.4 0.2 1.3 2 0 0 2 2 2 1 SprT-like family DA1-like PF12315.8 EFO65281.1 - 0.019 14.3 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein DA1 Peptidase_M48 PF01435.18 EFO65281.1 - 0.063 13.0 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 Peptidase family M48 Peptidase_M76 PF09768.9 EFO65281.1 - 0.1 12.4 0.3 0.19 11.5 0.3 1.4 1 1 0 1 1 1 0 Peptidase M76 family H2TH PF06831.14 EFO65282.1 - 1.4e-05 25.0 0.0 3.8e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Neil1-DNA_bind PF09292.10 EFO65282.1 - 0.00063 19.6 0.2 0.0011 18.9 0.2 1.4 1 0 0 1 1 1 1 Endonuclease VIII-like 1, DNA bind Fapy_DNA_glyco PF01149.24 EFO65282.1 - 0.0082 16.8 0.0 0.018 15.7 0.0 1.5 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain DUF4215 PF13948.6 EFO65282.1 - 0.12 12.9 0.3 6 7.4 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4215) WD40 PF00400.32 EFO65283.1 - 6e-09 36.4 8.7 0.0036 18.1 0.8 3.6 3 0 0 3 3 3 3 WD domain, G-beta repeat PUF PF00806.19 EFO65284.1 - 8.7e-19 66.1 9.2 3.6e-07 29.5 0.2 5.8 5 0 0 5 5 5 5 Pumilio-family RNA binding repeat S4 PF01479.25 EFO65285.1 - 5.1e-13 48.5 1.7 8.1e-13 47.9 0.3 2.0 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 EFO65285.1 - 2.7e-05 25.0 0.2 4.8e-05 24.2 0.2 1.7 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain GAS PF13851.6 EFO65286.1 - 0.0019 17.6 2.2 0.0019 17.6 2.2 4.3 3 1 1 4 4 4 2 Growth-arrest specific micro-tubule binding Prominin PF05478.11 EFO65286.1 - 0.0038 15.3 14.0 0.0071 14.4 6.1 2.3 2 0 0 2 2 2 2 Prominin DUF4376 PF14301.6 EFO65286.1 - 0.085 13.2 3.4 0.68 10.3 0.4 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4376) APG6_N PF17675.1 EFO65286.1 - 0.12 12.9 23.2 2.8 8.5 0.6 4.6 4 1 0 4 4 4 0 Apg6 coiled-coil region SlyX PF04102.12 EFO65286.1 - 1.2 9.8 0.0 1.2 9.8 0.0 6.7 5 2 1 7 7 7 0 SlyX TPR_MLP1_2 PF07926.12 EFO65286.1 - 1.4 9.0 29.5 0.24 11.5 1.1 4.7 4 0 0 4 4 4 0 TPR/MLP1/MLP2-like protein CLZ PF16526.5 EFO65286.1 - 2.1 8.8 14.6 31 5.0 0.2 5.2 4 1 1 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels HALZ PF02183.18 EFO65286.1 - 2.2 8.6 8.8 5.2 7.4 0.0 4.4 5 0 0 5 5 5 0 Homeobox associated leucine zipper DUF1664 PF07889.12 EFO65286.1 - 2.5 8.2 15.8 9.9 6.2 0.1 4.6 4 1 0 4 4 4 0 Protein of unknown function (DUF1664) Occludin_ELL PF07303.13 EFO65286.1 - 4.1 8.2 16.5 2.3 9.0 1.1 5.0 3 1 2 5 5 5 0 Occludin homology domain Nmad5 PF18757.1 EFO65286.1 - 4.3 7.5 9.7 3 8.0 0.3 3.1 3 1 0 3 3 3 0 Nucleotide modification associated domain 5 ParB PF08775.10 EFO65286.1 - 5.4 7.5 8.5 2.1 8.8 0.1 3.5 4 1 1 5 5 5 0 ParB family Fez1 PF06818.15 EFO65286.1 - 5.5 7.4 27.2 1.6 9.1 8.5 3.7 2 2 2 4 4 4 0 Fez1 DUF2802 PF10975.8 EFO65286.1 - 5.8 7.1 8.0 42 4.3 0.1 4.3 3 1 0 3 3 3 0 Protein of unknown function (DUF2802) DUF5082 PF16888.5 EFO65286.1 - 6 7.2 23.8 25 5.2 3.1 5.5 4 2 1 5 5 5 0 Domain of unknown function (DUF5082) Rootletin PF15035.6 EFO65286.1 - 6.9 6.7 23.5 0.077 13.0 3.3 4.2 3 2 1 4 4 4 0 Ciliary rootlet component, centrosome cohesion Ank_2 PF12796.7 EFO65287.1 - 1.3e-20 73.8 2.4 2.8e-09 37.5 0.1 3.4 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO65287.1 - 4.5e-10 39.6 4.4 0.0036 17.6 0.6 3.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65287.1 - 1e-09 37.8 0.5 0.12 12.9 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EFO65287.1 - 1e-06 29.1 0.6 0.0061 17.1 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO65287.1 - 1.4e-06 28.5 7.0 0.01 16.3 0.0 4.4 3 1 1 4 4 4 2 Ankyrin repeat Pox_A_type_inc PF04508.12 EFO65287.1 - 0.017 15.0 2.1 2.5 8.1 0.0 4.4 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat PDEase_I PF00233.19 EFO65288.1 - 1.1e-51 175.8 0.6 1.6e-50 172.1 0.6 2.4 1 1 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase eRF1_1 PF03463.15 EFO65289.1 - 3e-32 111.3 0.5 5e-32 110.6 0.5 1.4 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 EFO65289.1 - 2.4e-06 27.9 0.1 5.1e-06 26.8 0.1 1.6 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EFO65289.1 - 0.0018 18.7 0.1 0.0055 17.2 0.1 1.9 1 1 0 1 1 1 1 eRF1 domain 3 DUF2294 PF10057.9 EFO65289.1 - 0.039 14.1 0.1 0.13 12.4 0.1 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) Phage_T7_Capsid PF05396.11 EFO65289.1 - 0.067 13.6 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 Phage T7 capsid assembly protein Sec2p PF06428.11 EFO65290.1 - 0.00045 20.1 2.0 0.00045 20.1 2.0 2.1 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p Phage_GP20 PF06810.11 EFO65290.1 - 0.0074 16.1 4.9 0.01 15.6 0.7 2.0 1 1 1 2 2 2 1 Phage minor structural protein GP20 Syntaxin-6_N PF09177.11 EFO65290.1 - 0.034 14.7 5.5 1.1 9.9 5.5 2.1 1 1 0 1 1 1 0 Syntaxin 6, N-terminal SbsC_C PF18058.1 EFO65290.1 - 0.046 13.9 2.8 0.053 13.8 2.8 1.1 1 0 0 1 1 1 0 SbsC C-terminal domain Snapin_Pallidin PF14712.6 EFO65290.1 - 0.047 14.1 3.6 0.23 11.9 1.8 2.5 1 1 1 2 2 2 0 Snapin/Pallidin SlyX PF04102.12 EFO65290.1 - 0.099 13.3 3.1 0.62 10.7 0.8 2.2 1 1 1 2 2 2 0 SlyX DUF2175 PF09943.9 EFO65290.1 - 0.13 12.6 4.9 0.096 13.0 3.4 1.6 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) Tropomyosin_1 PF12718.7 EFO65290.1 - 0.13 12.4 9.9 0.052 13.7 3.2 2.1 1 1 1 2 2 2 0 Tropomyosin like DUF16 PF01519.16 EFO65290.1 - 0.21 12.1 3.8 4.6 7.8 3.8 2.0 1 1 0 1 1 1 0 Protein of unknown function DUF16 FAP206 PF12018.8 EFO65290.1 - 0.26 10.8 4.9 0.27 10.7 4.9 1.0 1 0 0 1 1 1 0 Domain of unknown function DUF4795 PF16043.5 EFO65290.1 - 0.26 10.9 7.5 0.12 12.0 3.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) APG6_N PF17675.1 EFO65290.1 - 0.29 11.6 8.3 0.36 11.4 8.3 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region XhlA PF10779.9 EFO65290.1 - 1.3 9.3 8.6 6.6 7.0 0.4 2.2 1 1 1 2 2 2 0 Haemolysin XhlA GIT_CC PF16559.5 EFO65291.1 - 0.0004 20.2 1.1 0.0004 20.2 1.1 2.6 3 0 0 3 3 2 1 GIT coiled-coil Rho guanine nucleotide exchange factor HALZ PF02183.18 EFO65291.1 - 0.0014 18.8 0.4 0.0041 17.3 0.4 1.8 1 0 0 1 1 1 1 Homeobox associated leucine zipper DUF4201 PF13870.6 EFO65291.1 - 0.0038 17.0 12.7 0.0053 16.5 7.3 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) Fungal_TACC PF12709.7 EFO65291.1 - 0.0046 17.4 3.1 0.0046 17.4 3.1 2.3 3 0 0 3 3 3 1 Fungal Transforming acidic coiled-coil (TACC) proteins CAAX_1 PF15895.5 EFO65291.1 - 0.19 11.6 3.7 0.066 13.1 1.0 1.5 2 0 0 2 2 1 0 CAAX box cerebral protein 1 DUF465 PF04325.13 EFO65291.1 - 0.2 11.7 3.4 0.22 11.6 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF465) CENP-Q PF13094.6 EFO65291.1 - 0.21 11.8 10.6 0.1 12.8 7.2 2.0 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit SCP-1 PF05483.12 EFO65291.1 - 0.21 9.5 11.5 0.016 13.2 6.6 1.5 2 0 0 2 2 2 0 Synaptonemal complex protein 1 (SCP-1) 2CSK_N PF08521.10 EFO65291.1 - 0.24 11.5 3.5 1.5 8.9 0.1 3.1 3 0 0 3 3 3 0 Two-component sensor kinase N-terminal Atg14 PF10186.9 EFO65291.1 - 0.33 10.0 11.1 0.26 10.4 6.9 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Lectin_N PF03954.14 EFO65291.1 - 0.37 10.5 4.6 1.1 9.1 2.8 2.4 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain FapA PF03961.13 EFO65291.1 - 0.38 9.3 7.4 0.042 12.4 3.0 1.6 2 0 0 2 2 2 0 Flagellar Assembly Protein A DUF4407 PF14362.6 EFO65291.1 - 0.53 9.6 13.6 0.047 13.0 7.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Lzipper-MIP1 PF14389.6 EFO65291.1 - 1.1 9.6 6.5 2.5 8.5 3.9 2.7 3 1 0 3 3 2 0 Leucine-zipper of ternary complex factor MIP1 HalX PF08663.10 EFO65291.1 - 1.3 9.4 8.2 0.42 11.0 4.5 2.2 2 0 0 2 2 2 0 HalX domain DUF5595 PF18077.1 EFO65291.1 - 1.9 8.6 5.7 0.24 11.5 0.5 2.3 3 0 0 3 3 1 0 Domain of unknown function (DUF5595) UPF0242 PF06785.11 EFO65291.1 - 2 8.5 7.6 0.84 9.7 3.4 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TMF_TATA_bd PF12325.8 EFO65291.1 - 4.3 7.6 15.0 3.3 8.0 11.2 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding OmpH PF03938.14 EFO65291.1 - 5.7 7.3 13.5 6 7.2 8.5 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) LMBR1 PF04791.16 EFO65291.1 - 7.3 5.4 6.2 1.6 7.5 2.3 1.8 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF4140 PF13600.6 EFO65291.1 - 8.7 6.9 10.6 9.5 6.7 2.7 2.8 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Filament PF00038.21 EFO65294.1 - 8.4e-06 25.6 18.4 0.0043 16.7 0.6 2.7 2 1 0 2 2 2 2 Intermediate filament protein ATG16 PF08614.11 EFO65294.1 - 2.3e-05 24.7 23.5 0.00016 22.0 13.0 3.0 3 0 0 3 3 3 2 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 EFO65294.1 - 3.2e-05 24.0 25.5 0.00016 21.7 0.5 3.3 2 1 1 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TSC22 PF01166.18 EFO65294.1 - 0.0012 19.1 12.6 0.0091 16.3 2.0 3.8 4 0 0 4 4 4 2 TSC-22/dip/bun family Lebercilin PF15619.6 EFO65294.1 - 0.0012 18.5 24.6 0.0054 16.4 0.7 2.7 2 1 0 2 2 2 2 Ciliary protein causing Leber congenital amaurosis disease FlaC_arch PF05377.11 EFO65294.1 - 0.01 16.2 10.0 0.042 14.2 0.1 4.0 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Spc7 PF08317.11 EFO65294.1 - 0.017 14.1 23.3 0.3 9.9 5.9 2.9 1 1 1 2 2 2 0 Spc7 kinetochore protein TMF_DNA_bd PF12329.8 EFO65294.1 - 0.019 15.0 23.3 0.068 13.2 1.3 4.0 3 2 1 4 4 4 0 TATA element modulatory factor 1 DNA binding TPR_MLP1_2 PF07926.12 EFO65294.1 - 0.043 13.9 20.7 0.14 12.2 0.4 3.3 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Fez1 PF06818.15 EFO65294.1 - 0.065 13.7 20.3 0.32 11.4 15.0 3.2 1 1 2 3 3 3 0 Fez1 Secretin_N PF03958.17 EFO65294.1 - 0.088 13.2 1.5 0.17 12.3 0.1 2.3 2 0 0 2 2 2 0 Bacterial type II/III secretion system short domain Jnk-SapK_ap_N PF09744.9 EFO65294.1 - 0.58 10.4 19.7 0.94 9.7 0.1 2.7 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 Bacillus_HBL PF05791.11 EFO65294.1 - 1.1 9.1 9.5 7.9 6.3 5.0 2.5 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) V_ATPase_I PF01496.19 EFO65294.1 - 1.6 6.6 13.2 0.34 8.8 0.4 2.2 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family Glyco_transf_4 PF13439.6 EFO65295.1 - 9.7e-21 74.5 2.5 1.2e-20 74.3 0.5 2.1 3 0 0 3 3 3 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EFO65295.1 - 9.1e-14 52.2 0.1 7e-13 49.3 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glycos_transf_1 PF00534.20 EFO65295.1 - 9.2e-13 48.1 0.0 1.9e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFO65295.1 - 2.4e-09 37.7 0.0 6e-09 36.4 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 EFO65295.1 - 1.9e-08 34.4 0.1 4.1e-08 33.4 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like PIGA PF08288.12 EFO65295.1 - 3.5e-06 27.5 0.6 1.6e-05 25.4 0.6 2.1 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_5 PF08323.11 EFO65295.1 - 0.0008 19.2 0.4 1.1 8.9 0.0 2.4 2 0 0 2 2 2 2 Starch synthase catalytic domain DHHC PF01529.20 EFO65297.1 - 3.3e-30 104.9 15.2 3.3e-30 104.9 15.2 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase TMEM252 PF15664.5 EFO65297.1 - 0.24 11.1 0.5 17 5.1 0.1 2.4 2 0 0 2 2 2 0 Transmembrane protein 252 family DUF2207 PF09972.9 EFO65297.1 - 2.2 6.9 9.9 7.1 5.3 4.9 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) PKcGMP_CC PF16808.5 EFO65298.1 - 0.022 14.6 0.3 0.057 13.3 0.3 1.7 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Cnn_1N PF07989.11 EFO65298.1 - 0.11 12.7 0.4 0.11 12.7 0.4 2.6 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 SlyX PF04102.12 EFO65298.1 - 0.13 12.8 3.9 4.9 7.8 0.0 2.8 3 0 0 3 3 3 0 SlyX End3 PF12761.7 EFO65298.1 - 0.14 12.3 1.8 9 6.4 0.0 2.5 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 Spc24 PF08286.11 EFO65298.1 - 0.27 11.5 4.9 0.12 12.6 1.3 2.3 2 2 1 3 3 3 0 Spc24 subunit of Ndc80 ZapB PF06005.12 EFO65298.1 - 0.69 10.4 3.5 0.38 11.2 0.6 2.0 2 1 0 2 2 2 0 Cell division protein ZapB TM1586_NiRdase PF14512.6 EFO65299.1 - 7.2e-16 58.4 0.0 8.8e-16 58.1 0.0 1.1 1 0 0 1 1 1 1 Putative TM nitroreductase Nitroreductase PF00881.24 EFO65299.1 - 9.5e-06 25.8 0.0 0.00029 20.9 0.0 2.4 2 1 1 3 3 3 1 Nitroreductase family PCI PF01399.27 EFO65300.1 - 0.027 15.0 1.4 0.36 11.4 0.0 3.3 2 2 0 2 2 2 0 PCI domain RRM_1 PF00076.22 EFO65301.1 - 3.1e-05 23.7 0.1 6.4e-05 22.7 0.1 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFO65301.1 - 0.025 14.7 0.0 0.046 13.8 0.0 1.5 1 1 0 1 1 1 0 RNA recognition motif PHD PF00628.29 EFO65302.1 - 3.2e-06 26.9 10.5 5.6e-06 26.1 10.5 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EFO65302.1 - 0.069 12.7 4.9 0.18 11.4 4.9 1.7 1 0 0 1 1 1 0 PHD-finger zf-RING_9 PF13901.6 EFO65302.1 - 0.11 12.4 6.3 0.19 11.7 6.3 1.3 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon C1_1 PF00130.22 EFO65302.1 - 5.3 7.0 13.2 0.61 10.0 8.4 1.8 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) adh_short PF00106.25 EFO65303.1 - 1e-25 90.3 0.0 1.7e-25 89.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFO65303.1 - 9.4e-12 45.0 0.2 1.4e-11 44.5 0.2 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFO65303.1 - 6.1e-08 32.8 0.0 1e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFO65303.1 - 4.5e-05 23.0 0.1 0.00011 21.8 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF2024 PF09630.10 EFO65304.1 - 0.074 12.9 0.3 2.4 8.1 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF2024) Atg14 PF10186.9 EFO65305.1 - 0.02 14.0 5.8 0.048 12.7 5.7 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 SKA2 PF16740.5 EFO65305.1 - 0.023 14.5 10.7 0.033 14.0 4.9 2.7 1 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Tropomyosin_1 PF12718.7 EFO65305.1 - 0.14 12.3 8.8 0.26 11.4 8.8 1.3 1 0 0 1 1 1 0 Tropomyosin like Allexi_40kDa PF05549.11 EFO65305.1 - 0.29 10.6 6.5 0.085 12.4 0.9 2.2 1 1 1 2 2 2 0 Allexivirus 40kDa protein HMMR_N PF15905.5 EFO65305.1 - 0.32 10.4 11.1 2.2 7.6 4.8 2.3 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal SPATA24 PF15175.6 EFO65305.1 - 0.89 9.4 7.9 0.32 10.9 1.1 2.4 1 1 1 2 2 2 0 Spermatogenesis-associated protein 24 TMPIT PF07851.13 EFO65305.1 - 1.1 8.4 4.6 1.8 7.7 3.9 1.6 1 1 1 2 2 2 0 TMPIT-like protein TMF_TATA_bd PF12325.8 EFO65305.1 - 1.3 9.3 10.1 3 8.1 1.4 2.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding FAM76 PF16046.5 EFO65305.1 - 2.3 7.5 8.3 12 5.1 1.3 2.0 1 1 1 2 2 2 0 FAM76 protein Fez1 PF06818.15 EFO65305.1 - 3.3 8.1 11.8 60 4.0 11.6 2.4 1 1 1 2 2 2 0 Fez1 ATG16 PF08614.11 EFO65305.1 - 4.1 7.6 10.4 5.9 7.1 5.0 2.5 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) VSP PF03302.13 EFO65306.1 - 6e-69 232.8 145.9 1.7e-40 139.2 26.3 4.7 1 1 2 3 3 3 3 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO65306.1 - 0.017 15.3 0.2 0.048 13.8 0.0 1.9 2 0 0 2 2 2 0 Podoplanin Peptidase_C1 PF00112.23 EFO65307.1 - 2.9e-59 200.8 2.2 3.4e-59 200.6 2.2 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFO65307.1 - 3.6e-07 29.3 0.1 0.00083 18.2 0.2 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Propeptide_C1 PF08127.13 EFO65307.1 - 0.039 13.9 0.0 0.064 13.2 0.0 1.4 1 0 0 1 1 1 0 Peptidase family C1 propeptide Peptidase_C12 PF01088.21 EFO65308.1 - 0.0001 22.2 0.0 0.00029 20.6 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Ank_2 PF12796.7 EFO65309.1 - 4.3e-47 158.6 6.1 8.1e-11 42.4 0.0 5.8 4 1 1 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO65309.1 - 2.3e-28 97.9 10.9 4.5e-05 23.6 0.0 9.0 5 4 5 10 10 10 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65309.1 - 3.6e-21 73.0 3.6 0.0067 16.9 0.0 10.8 10 0 0 10 10 10 3 Ankyrin repeat Ank PF00023.30 EFO65309.1 - 1.4e-19 69.6 12.2 0.0014 19.0 0.0 10.0 10 1 0 10 10 10 4 Ankyrin repeat Ank_4 PF13637.6 EFO65309.1 - 3.7e-19 68.8 8.6 0.0025 18.3 0.1 8.3 6 2 2 8 8 8 6 Ankyrin repeats (many copies) IL6 PF00489.17 EFO65309.1 - 0.0038 16.8 3.6 0.0058 16.2 0.2 3.1 3 0 0 3 3 3 1 Interleukin-6/G-CSF/MGF family GAS PF13851.6 EFO65309.1 - 0.016 14.5 0.5 0.016 14.5 0.5 6.6 4 3 1 5 5 5 0 Growth-arrest specific micro-tubule binding PKcGMP_CC PF16808.5 EFO65309.1 - 0.28 11.1 21.7 5.7 6.9 0.6 6.2 5 0 0 5 5 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4407 PF14362.6 EFO65309.1 - 0.46 9.8 52.3 1.3 8.3 7.1 5.2 2 2 2 4 4 4 0 Domain of unknown function (DUF4407) TMF_DNA_bd PF12329.8 EFO65309.1 - 6.5 6.8 51.8 0.11 12.4 0.2 9.4 8 1 1 9 9 9 0 TATA element modulatory factor 1 DNA binding RNA_pol_Rpb8 PF03870.15 EFO65310.1 - 9e-22 77.8 0.0 1e-21 77.6 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 EFO65310.1 - 0.0022 18.0 0.0 0.003 17.6 0.0 1.4 1 0 0 1 1 1 1 DNA-directed RNA polymerase, subunit G Orthopox_A43R PF06517.11 EFO65310.1 - 0.07 12.9 0.4 0.086 12.6 0.4 1.1 1 0 0 1 1 1 0 Orthopoxvirus A43R protein AAA PF00004.29 EFO65313.1 - 2.5e-09 37.6 0.0 5.3e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFO65313.1 - 4e-06 27.1 0.1 2.2e-05 24.7 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFO65313.1 - 0.00011 22.6 0.3 0.00094 19.6 0.3 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 EFO65313.1 - 0.0018 18.1 0.0 0.0033 17.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EFO65313.1 - 0.0022 17.7 0.0 0.0046 16.7 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_18 PF13238.6 EFO65313.1 - 0.008 16.7 0.0 0.019 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EFO65313.1 - 0.0092 15.9 0.9 0.76 9.7 0.5 2.7 2 1 0 2 2 2 1 NACHT domain AAA_5 PF07728.14 EFO65313.1 - 0.011 15.7 0.0 0.027 14.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EFO65313.1 - 0.018 15.1 0.0 0.05 13.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 EFO65313.1 - 0.023 14.5 0.0 1.6 8.4 0.0 2.5 2 0 0 2 2 2 0 DEAD/DEAH box helicase ATPase PF06745.13 EFO65313.1 - 0.023 14.0 0.0 0.094 12.1 0.0 1.9 1 1 1 2 2 2 0 KaiC AAA_33 PF13671.6 EFO65313.1 - 0.036 14.2 0.0 0.087 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EFO65313.1 - 0.037 13.9 0.2 0.13 12.1 0.0 2.0 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EFO65313.1 - 0.041 13.6 0.0 0.19 11.4 0.0 2.0 1 1 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 EFO65313.1 - 0.061 13.7 0.0 0.18 12.2 0.0 1.9 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 EFO65313.1 - 0.11 12.5 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EFO65313.1 - 0.11 12.0 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region NB-ARC PF00931.22 EFO65313.1 - 0.12 11.5 0.0 0.31 10.2 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain Ank_2 PF12796.7 EFO65314.1 - 6.9e-40 135.5 11.7 9.9e-11 42.1 0.1 6.6 3 3 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO65314.1 - 5.2e-22 77.6 16.2 0.0003 21.0 0.0 9.4 5 2 5 10 10 10 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO65314.1 - 4.2e-16 58.6 12.2 0.17 12.4 0.0 9.8 11 0 0 11 11 11 5 Ankyrin repeat Ank_4 PF13637.6 EFO65314.1 - 2.5e-15 56.6 4.3 0.0032 18.0 0.0 8.2 8 0 0 8 8 8 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65314.1 - 8.6e-13 47.2 14.6 1.4 9.7 0.0 10.0 11 0 0 11 11 11 3 Ankyrin repeat CCDC144C PF14915.6 EFO65314.1 - 0.0008 18.6 10.6 0.0008 18.6 10.6 4.4 4 1 1 5 5 5 1 CCDC144C protein coiled-coil region Shugoshin_N PF07558.11 EFO65314.1 - 0.12 12.3 4.2 2.1 8.3 0.0 3.3 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region IFP_35_N PF07334.13 EFO65314.1 - 0.84 9.7 7.0 7.4 6.7 0.7 3.5 3 0 0 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DUF1319 PF07028.11 EFO65314.1 - 2 8.7 6.6 4.8 7.4 0.3 4.4 3 1 1 4 4 4 0 Protein of unknown function (DUF1319) Ank_2 PF12796.7 EFO65315.1 - 2.9e-11 43.8 5.0 1.4e-10 41.6 0.8 2.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFO65315.1 - 9.7e-07 29.0 0.3 0.0086 16.5 0.1 3.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EFO65315.1 - 0.00019 22.0 0.6 0.0095 16.5 0.2 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO65315.1 - 0.0011 19.3 0.4 0.24 11.8 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65315.1 - 0.0022 18.3 0.2 0.26 12.0 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat KASH_CCD PF14662.6 EFO65315.1 - 0.0026 17.6 7.8 0.0026 17.6 7.8 10.9 6 1 3 10 10 10 2 Coiled-coil region of CCDC155 or KASH DUF148 PF02520.17 EFO65315.1 - 0.0065 16.6 0.3 0.0065 16.6 0.3 9.8 10 3 2 12 12 12 2 Domain of unknown function DUF148 Syntaxin-18_N PF10496.9 EFO65315.1 - 0.47 10.7 8.1 0.85 9.9 1.9 3.8 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus AA_permease_2 PF13520.6 EFO65316.1 - 8.5e-27 94.0 31.8 8.3e-26 90.8 26.3 2.1 2 0 0 2 2 2 2 Amino acid permease AA_permease PF00324.21 EFO65316.1 - 8.2e-07 28.0 27.3 8.8e-07 27.9 22.6 2.6 2 1 0 2 2 2 1 Amino acid permease CobD_Cbib PF03186.13 EFO65316.1 - 0.031 13.5 0.7 0.13 11.4 0.1 2.3 2 0 0 2 2 2 0 CobD/Cbib protein Synaptobrevin PF00957.21 EFO65317.1 - 3.2e-17 62.1 2.1 4.9e-17 61.5 2.1 1.3 1 0 0 1 1 1 1 Synaptobrevin T2SSF PF00482.23 EFO65317.1 - 0.0094 15.9 1.8 0.03 14.3 0.7 2.2 2 1 0 2 2 2 1 Type II secretion system (T2SS), protein F Prominin PF05478.11 EFO65317.1 - 0.035 12.1 0.2 0.046 11.7 0.2 1.3 1 0 0 1 1 1 0 Prominin Sec20 PF03908.13 EFO65317.1 - 0.044 13.7 0.1 0.1 12.5 0.1 1.6 1 0 0 1 1 1 0 Sec20 SNARE PF05739.19 EFO65317.1 - 0.072 13.1 4.7 0.27 11.2 4.7 2.1 1 1 0 1 1 1 0 SNARE domain UPF0258 PF06789.12 EFO65317.1 - 0.089 12.9 0.5 0.13 12.4 0.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) DUF5383 PF17355.2 EFO65317.1 - 0.1 13.0 0.2 0.21 11.9 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5383) DUF2970 PF11174.8 EFO65317.1 - 6.2 6.8 8.3 1.7 8.5 1.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) Ham1p_like PF01725.16 EFO65318.1 - 4.4e-46 157.2 0.0 5e-46 157.0 0.0 1.0 1 0 0 1 1 1 1 Ham1 family PTPLA PF04387.14 EFO65319.1 - 3.3e-36 124.5 9.6 7.5e-36 123.3 9.6 1.5 1 1 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA AGTRAP PF06396.11 EFO65319.1 - 0.0022 17.8 11.9 0.009 15.8 0.7 3.1 2 1 1 3 3 3 3 Angiotensin II, type I receptor-associated protein (AGTRAP) NUDIX PF00293.28 EFO65320.1 - 0.00036 20.6 0.0 0.00041 20.4 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Pkinase PF00069.25 EFO65321.1 - 1.4e-30 106.5 0.0 2.7e-30 105.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65321.1 - 3.9e-20 72.2 0.0 8.8e-20 71.1 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO65321.1 - 2.9e-14 53.4 0.0 9.8e-14 51.7 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO65321.1 - 2e-07 31.2 0.0 4.9e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO65321.1 - 4.1e-06 27.2 0.0 0.011 16.3 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO65321.1 - 2.1e-05 24.8 0.0 0.024 15.1 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EFO65321.1 - 0.00075 19.8 0.0 0.52 11.1 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeat Kinase-like PF14531.6 EFO65321.1 - 0.0041 16.5 0.2 0.18 11.1 0.0 2.5 3 0 0 3 3 3 1 Kinase-like DUF4572 PF15139.6 EFO65321.1 - 0.056 13.4 4.8 0.9 9.4 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4572) CdvA PF18822.1 EFO65321.1 - 0.2 11.5 5.0 3.3 7.5 0.5 2.5 2 0 0 2 2 2 0 CdvA-like coiled-coil domain DUF917 PF06032.12 EFO65322.1 - 0.046 12.6 0.0 0.061 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF917) RVT_1 PF00078.27 EFO65323.1 - 1.8e-26 93.1 0.0 2.5e-26 92.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transglut_core PF01841.19 EFO65324.1 - 0.043 14.3 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 Transglutaminase-like superfamily Cnd1 PF12717.7 EFO65325.1 - 0.0015 18.6 0.5 0.012 15.7 0.1 2.8 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFO65325.1 - 0.049 13.9 0.2 1.6 9.2 0.0 3.4 3 0 0 3 3 3 0 HEAT repeat Rab_bind PF16704.5 EFO65325.1 - 0.083 12.9 0.1 0.23 11.5 0.1 1.7 1 0 0 1 1 1 0 Rab binding domain DUF420 PF04238.12 EFO65325.1 - 0.47 10.7 3.5 11 6.2 0.9 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF420) EGF_2 PF07974.13 EFO65328.1 - 6.9e-23 80.7 270.0 0.00013 22.3 5.0 19.7 18 1 0 18 18 18 14 EGF-like domain EGF PF00008.27 EFO65328.1 - 9e-09 35.5 52.1 0.00043 20.5 2.0 20.5 20 2 1 21 21 21 10 EGF-like domain hEGF PF12661.7 EFO65328.1 - 0.014 16.0 2.6 0.014 16.0 2.6 20.9 20 3 1 21 21 21 0 Human growth factor-like EGF Vpu PF00558.19 EFO65328.1 - 0.27 11.0 0.1 0.48 10.2 0.1 1.3 1 0 0 1 1 1 0 Vpu protein SKG6 PF08693.10 EFO65328.1 - 4.9 6.6 6.6 10 5.6 6.6 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Adap_comp_sub PF00928.21 EFO65329.1 - 2.7e-46 158.1 2.1 3.6e-46 157.7 2.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EFO65329.1 - 0.0007 19.5 0.1 0.0012 18.8 0.1 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Dpy-30 PF05186.13 EFO65330.1 - 2.1e-06 27.3 0.0 3.2e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Dpy-30 motif Fib_alpha PF08702.10 EFO65332.1 - 0.0067 16.6 3.2 0.0067 16.6 3.2 5.5 4 1 1 5 5 5 3 Fibrinogen alpha/beta chain family Bcr-Abl_Oligo PF09036.10 EFO65333.1 - 0.039 13.9 0.1 0.17 11.9 0.1 2.1 1 0 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain DUF2634 PF10934.8 EFO65333.1 - 0.085 13.0 0.1 0.28 11.3 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2634) TMF_DNA_bd PF12329.8 EFO65333.1 - 0.13 12.3 0.4 0.13 12.3 0.4 3.1 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding SKA2 PF16740.5 EFO65333.1 - 0.48 10.2 5.5 1.7 8.4 0.4 3.1 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 Takusan PF04822.13 EFO65333.1 - 1.5 8.8 8.0 14 5.6 0.2 2.5 2 0 0 2 2 2 0 Takusan RNase_H PF00075.24 EFO65334.1 - 1.9e-24 86.5 0.0 3.1e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 RNase H MIP-T3 PF10243.9 EFO65336.1 - 4.7e-23 81.3 0.0 1.3e-22 79.9 0.0 1.8 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 CH-like domain MIP-T3_C PF17749.1 EFO65336.1 - 6.1e-06 26.3 0.4 6.1e-06 26.3 0.4 3.1 2 1 0 2 2 1 1 Microtubule-binding protein MIP-T3 C-terminal region MetallophosC PF16370.5 EFO65336.1 - 0.37 11.0 1.3 1.9 8.7 0.0 2.3 1 1 1 2 2 2 0 C terminal of Calcineurin-like phosphoesterase SpoIIP PF07454.11 EFO65336.1 - 0.42 10.0 11.4 0.89 9.0 11.4 1.8 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DDRGK PF09756.9 EFO65336.1 - 1.1 8.9 35.0 2.3 7.8 35.0 1.5 1 0 0 1 1 1 0 DDRGK domain Borrelia_P83 PF05262.11 EFO65336.1 - 1.2 7.5 17.1 1.6 7.1 17.1 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein Rrn6 PF10214.9 EFO65336.1 - 1.3 7.5 24.0 0.12 10.9 19.7 1.5 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor DUF4746 PF15928.5 EFO65336.1 - 3.1 7.1 18.8 4.9 6.5 18.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) HAUS6_N PF14661.6 EFO65336.1 - 3.8 7.0 21.2 5.4 6.5 1.6 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Peptidase_U57 PF05582.12 EFO65336.1 - 6.2 6.0 10.5 14 4.8 10.5 1.6 1 0 0 1 1 1 0 YabG peptidase U57 Zip PF02535.22 EFO65336.1 - 6.6 5.9 7.4 14 4.8 7.4 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 EFO65336.1 - 7 4.8 20.1 11 4.2 20.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Merozoite_SPAM PF07133.11 EFO65336.1 - 7.7 6.5 28.5 2.1 8.3 24.0 2.1 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) Asp-B-Hydro_N PF05279.11 EFO65336.1 - 8.7 6.3 21.8 18 5.3 21.8 1.6 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region AAA_28 PF13521.6 EFO65337.1 - 0.052 13.8 0.0 0.098 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain TetR_C_24 PF17932.1 EFO65338.1 - 0.13 12.5 0.6 0.6 10.4 0.1 2.4 1 1 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain ATG16 PF08614.11 EFO65338.1 - 0.42 10.8 49.2 0.13 12.5 19.3 5.6 4 2 1 5 5 5 0 Autophagy protein 16 (ATG16) EntA_Immun PF08951.10 EFO65338.1 - 0.74 10.2 8.4 1.2 9.6 4.4 3.5 2 0 0 2 2 2 0 Enterocin A Immunity CENP-O PF09496.10 EFO65338.1 - 0.81 9.6 10.7 0.23 11.4 6.2 2.4 2 1 0 2 2 2 0 Cenp-O kinetochore centromere component DUF948 PF06103.11 EFO65338.1 - 1.5 9.1 21.4 0.17 12.2 2.7 5.2 5 1 0 5 5 5 0 Bacterial protein of unknown function (DUF948) MAD PF05557.13 EFO65338.1 - 3.1 6.1 44.3 0.021 13.2 28.5 3.1 3 0 0 3 3 3 0 Mitotic checkpoint protein NPV_P10 PF05531.12 EFO65338.1 - 7.2 7.2 14.1 2.8 8.5 0.4 4.3 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Ank_2 PF12796.7 EFO65339.1 - 9e-17 61.4 9.6 1.1e-07 32.4 0.0 5.1 2 2 4 6 6 6 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO65339.1 - 7e-09 35.2 4.2 3.1 8.7 0.0 7.1 7 0 0 7 7 7 3 Ankyrin repeat Ank PF00023.30 EFO65339.1 - 3.4e-06 27.2 9.6 0.39 11.2 0.5 6.6 6 1 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 EFO65339.1 - 1.5e-05 25.2 2.0 0.15 12.4 0.0 5.0 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO65340.1 - 3.7e-17 62.6 0.0 3.7e-08 33.1 0.0 2.3 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65340.1 - 2e-12 47.0 0.0 3e-11 43.1 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase DUF3071 PF11268.8 EFO65340.1 - 0.22 11.6 0.0 0.33 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) Cyt-b5 PF00173.28 EFO65342.1 - 1.9e-18 66.4 0.0 2.8e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DJ-1_PfpI PF01965.24 EFO65343.1 - 1.6e-40 138.7 0.1 1.8e-40 138.4 0.1 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 EFO65343.1 - 0.13 12.1 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferase class-I Polysacc_synt_4 PF04669.13 EFO65344.1 - 1.4e-20 73.7 0.0 1.2e-18 67.3 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis SHIPPO-rpt PF07004.12 EFO65345.1 - 3.2e-09 37.2 9.8 0.31 12.0 0.8 6.1 6 0 0 6 6 6 4 Sperm-tail PG-rich repeat SHIPPO-rpt PF07004.12 EFO65346.1 - 5e-14 52.5 28.2 0.024 15.5 0.2 8.8 9 0 0 9 9 9 6 Sperm-tail PG-rich repeat ECR1_N PF14382.6 EFO65346.1 - 2.2 8.2 11.8 19 5.2 0.0 5.3 4 2 1 5 5 5 0 Exosome complex exonuclease RRP4 N-terminal region Pkinase PF00069.25 EFO65347.1 - 2.3e-42 145.2 0.0 4.2e-42 144.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65347.1 - 2.8e-22 79.2 0.0 4.9e-22 78.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF713 PF05218.14 EFO65347.1 - 0.072 12.8 0.5 0.34 10.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF713) Ank_2 PF12796.7 EFO65349.1 - 2.1e-42 143.6 0.0 1.7e-18 67.0 0.0 4.1 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO65349.1 - 3.5e-38 131.5 0.0 1.6e-37 129.3 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Ank_4 PF13637.6 EFO65349.1 - 9.7e-33 112.1 0.0 3.5e-10 40.2 0.0 6.7 4 2 2 6 6 6 5 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFO65349.1 - 1.3e-28 100.0 0.0 2.2e-28 99.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ank PF00023.30 EFO65349.1 - 2.2e-28 97.4 0.2 8.8e-05 22.8 0.0 6.6 6 0 0 6 6 6 6 Ankyrin repeat Ank_3 PF13606.6 EFO65349.1 - 6.1e-28 93.8 0.2 0.00017 21.7 0.0 7.7 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.6 EFO65349.1 - 5.9e-27 93.4 3.4 1.5e-06 28.4 0.0 6.5 1 1 5 6 6 6 6 Ankyrin repeats (many copies) APH PF01636.23 EFO65349.1 - 0.0085 16.0 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family GAS PF13851.6 EFO65349.1 - 0.011 15.1 0.4 0.018 14.4 0.4 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF3450 PF11932.8 EFO65349.1 - 0.056 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF3584 PF12128.8 EFO65349.1 - 0.078 10.5 0.4 0.11 10.1 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF3323 PF11796.8 EFO65349.1 - 0.084 12.8 3.3 0.36 10.7 2.6 2.4 2 2 1 3 3 3 0 Protein of unknown function N-terminus (DUF3323) Bclx_interact PF08945.10 EFO65349.1 - 5.3 6.9 5.1 0.94 9.3 0.2 2.4 4 0 0 4 4 4 0 Bcl-x interacting, BH3 domain UCH PF00443.29 EFO65350.1 - 3.4e-17 62.8 0.0 7.9e-13 48.5 0.0 2.7 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EFO65350.1 - 1.8e-12 47.4 18.9 1.8e-12 47.4 18.9 2.9 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EFO65350.1 - 9.1e-10 38.6 16.7 4.3e-07 29.8 5.4 4.1 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EFO65350.1 - 5.6e-09 36.5 0.0 1.9e-08 34.8 0.0 1.9 1 0 0 1 1 1 1 DUSP domain Aa_trans PF01490.18 EFO65352.1 - 2.9e-54 184.3 38.4 4e-54 183.9 38.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 EFO65352.1 - 8.3e-06 24.9 32.2 8.3e-06 24.9 32.2 2.3 1 1 1 2 2 2 1 Amino acid permease Urb2 PF10441.9 EFO65353.1 - 7.1 6.5 10.0 16 5.4 1.2 3.5 3 1 1 4 4 4 0 Urb2/Npa2 family MDD_C PF18376.1 EFO65354.1 - 2.2e-12 47.1 0.0 3.3e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 EFO65354.1 - 4.2e-08 33.3 1.1 1.2e-07 31.9 1.1 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain DUF5470 PF17564.2 EFO65354.1 - 0.18 12.0 0.1 0.46 10.7 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5470) AAA_16 PF13191.6 EFO65355.1 - 0.015 15.7 0.0 0.085 13.2 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 EFO65355.1 - 0.039 14.5 0.0 0.13 12.8 0.0 2.0 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 EFO65355.1 - 0.04 13.4 0.7 0.14 11.5 0.0 2.3 3 0 0 3 3 3 0 Chromatin associated protein KTI12 AAA_lid_5 PF17865.1 EFO65355.1 - 0.065 13.3 0.8 0.32 11.1 0.1 2.6 3 0 0 3 3 3 0 Midasin AAA lid domain IL3Ra_N PF18611.1 EFO65356.1 - 0.12 12.3 0.2 6.3 6.9 0.0 2.4 2 0 0 2 2 2 0 IL-3 receptor alpha chain N-terminal domain Wzz PF02706.15 EFO65357.1 - 0.13 12.5 0.7 0.23 11.8 0.0 1.8 2 0 0 2 2 2 0 Chain length determinant protein Pkinase PF00069.25 EFO65358.1 - 5.3e-21 75.2 0.0 9.2e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65358.1 - 9.2e-11 41.5 0.0 1.4e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase zf-DBF PF07535.12 EFO65360.1 - 0.0039 17.3 0.3 0.0039 17.3 0.3 2.8 3 0 0 3 3 3 1 DBF zinc finger BRCT PF00533.26 EFO65361.1 - 0.04 14.3 0.0 0.1 13.0 0.0 1.8 1 1 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Ribosomal_L12 PF00542.19 EFO65361.1 - 0.17 12.2 3.2 1.4 9.3 0.1 3.0 2 0 0 2 2 2 0 Ribosomal protein L7/L12 C-terminal domain Sybindin PF04099.12 EFO65362.1 - 2.5e-26 92.3 0.0 2.8e-26 92.1 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EFO65362.1 - 3.6e-06 27.1 0.0 3.8e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Myb_DNA-binding PF00249.31 EFO65363.1 - 7.3e-13 48.5 0.4 1e-10 41.6 0.5 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFO65363.1 - 1.7e-11 44.2 0.1 5.4e-09 36.2 0.1 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain TRAM_LAG1_CLN8 PF03798.16 EFO65364.1 - 1.9e-27 96.3 13.5 3.1e-27 95.6 13.5 1.3 1 0 0 1 1 1 1 TLC domain CD20 PF04103.15 EFO65364.1 - 0.0031 17.6 0.2 0.0086 16.2 0.2 1.8 1 0 0 1 1 1 1 CD20-like family CRPA PF05745.11 EFO65364.1 - 0.39 10.7 1.7 1.1 9.2 0.1 2.3 2 1 0 2 2 2 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) zf-C2HC_2 PF13913.6 EFO65365.1 - 6.5e-08 32.3 3.0 6.5e-08 32.3 3.0 3.9 3 2 1 4 4 4 1 zinc-finger of a C2HC-type zf-Di19 PF05605.12 EFO65365.1 - 0.00013 22.2 13.9 0.0021 18.3 0.5 3.4 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding TRAF6_Z2 PF18048.1 EFO65365.1 - 0.0011 19.0 3.3 0.36 10.9 1.9 2.8 2 0 0 2 2 2 2 TNF receptor-associated factor 6 zinc finger 2 FYVE PF01363.21 EFO65365.1 - 0.0023 18.1 10.3 0.013 15.6 0.3 3.4 3 0 0 3 3 3 2 FYVE zinc finger Prok-RING_1 PF14446.6 EFO65365.1 - 0.0026 17.6 13.4 0.049 13.6 0.5 3.3 3 0 0 3 3 3 2 Prokaryotic RING finger family 1 DZR PF12773.7 EFO65365.1 - 0.0048 16.9 0.5 0.0048 16.9 0.5 3.3 2 1 0 2 2 2 1 Double zinc ribbon zf-ribbon_3 PF13248.6 EFO65365.1 - 0.032 13.6 18.2 0.73 9.3 4.8 4.1 3 1 1 4 4 4 0 zinc-ribbon domain Prok-RING_4 PF14447.6 EFO65365.1 - 0.26 11.2 4.4 0.49 10.3 0.1 3.0 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 Rad50_zn_hook PF04423.14 EFO65365.1 - 0.39 10.6 3.2 11 6.0 0.3 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif HypA PF01155.19 EFO65365.1 - 1.1 9.3 9.8 11 6.1 0.2 3.2 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_jaz PF12171.8 EFO65365.1 - 2.2 8.7 6.9 10 6.5 0.0 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zinc-ribbons_6 PF07191.12 EFO65365.1 - 4 7.5 13.9 1.2 9.2 1.8 3.2 3 0 0 3 3 3 0 zinc-ribbons zinc_ribbon_4 PF13717.6 EFO65365.1 - 4.3 7.3 7.6 11 6.0 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain zf_C2H2_6 PF18450.1 EFO65365.1 - 7.6 6.3 10.9 0.89 9.3 0.7 3.2 3 0 0 3 3 3 0 Zinc Finger domain zinc_ribbon_2 PF13240.6 EFO65365.1 - 7.9 6.3 23.7 2.3 8.0 8.4 4.0 3 1 0 3 3 3 0 zinc-ribbon domain RRM_1 PF00076.22 EFO65366.1 - 5.4e-19 67.8 0.2 2.2e-05 24.2 0.0 5.2 5 0 0 5 5 5 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4866 PF16160.5 EFO65366.1 - 0.039 13.3 0.1 0.46 9.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4866) Kinesin PF00225.23 EFO65367.1 - 3.1e-75 253.2 0.1 4.2e-37 127.8 0.0 2.2 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 EFO65367.1 - 3.1e-13 49.9 0.0 8.1e-13 48.6 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding BsuBI_PstI_RE PF06616.11 EFO65367.1 - 0.089 12.1 0.2 6.7 6.0 0.2 2.3 2 0 0 2 2 2 0 BsuBI/PstI restriction endonuclease domain HSBP1 PF06825.12 EFO65368.1 - 0.0015 18.3 0.2 2.1 8.2 0.0 3.8 2 0 0 2 2 2 2 Heat shock factor binding protein 1 HOOK PF05622.12 EFO65368.1 - 0.0016 16.7 0.2 0.0016 16.7 0.2 2.4 2 1 0 2 2 2 1 HOOK protein FlaC_arch PF05377.11 EFO65368.1 - 0.034 14.5 8.4 26 5.3 0.0 5.7 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) YojJ PF10372.9 EFO65368.1 - 0.049 13.7 2.8 1 9.5 0.2 4.1 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus Phage_GP20 PF06810.11 EFO65368.1 - 0.051 13.4 0.1 0.051 13.4 0.1 3.2 3 0 0 3 3 3 0 Phage minor structural protein GP20 Baculo_p24 PF05073.12 EFO65368.1 - 0.11 12.3 14.5 0.081 12.7 0.6 5.0 5 0 0 5 5 5 0 Baculovirus P24 capsid protein Cep57_CLD_2 PF14197.6 EFO65368.1 - 2.2 8.4 6.3 0.71 10.0 0.4 3.1 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 PIN_8 PF18476.1 EFO65368.1 - 7.6 6.3 13.7 0.27 11.1 3.1 3.6 3 1 0 4 4 4 0 PIN like domain Clat_adaptor_s PF01217.20 EFO65369.1 - 0.00011 22.2 0.0 0.00012 22.0 0.0 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ribosomal_L35Ae PF01247.18 EFO65370.1 - 1.9e-27 95.3 0.1 2.4e-27 94.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 EFO65370.1 - 9e-05 22.6 0.0 0.037 14.3 0.0 2.1 2 0 0 2 2 2 2 RimM N-terminal domain TPR_2 PF07719.17 EFO65371.1 - 4.2e-12 45.2 3.4 3.4e-05 23.6 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFO65371.1 - 6.4e-12 45.6 0.6 1.1e-11 44.8 0.6 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFO65371.1 - 1.1e-10 40.8 2.6 0.00021 21.0 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFO65371.1 - 8.5e-10 38.6 1.5 1.3e-05 25.6 0.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFO65371.1 - 8.7e-10 39.1 0.3 1.8e-09 38.1 0.3 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFO65371.1 - 5.1e-09 35.7 1.9 0.0014 18.3 0.8 2.4 2 0 0 2 2 2 2 TPR repeat TPR_19 PF14559.6 EFO65371.1 - 3.1e-08 34.0 0.4 5.7e-08 33.2 0.4 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFO65371.1 - 9e-08 31.7 4.7 0.00076 19.5 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFO65371.1 - 2.6e-06 27.1 5.3 0.0025 17.6 1.2 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFO65371.1 - 9.5e-06 25.3 0.4 0.19 11.8 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_4 PF07721.14 EFO65371.1 - 2.5e-05 24.5 0.3 0.00067 20.1 0.2 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFO65371.1 - 0.00012 22.2 0.7 0.00058 20.0 0.7 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Coatomer_E PF04733.14 EFO65371.1 - 0.00088 18.8 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_MalT PF17874.1 EFO65371.1 - 0.0014 18.1 0.1 0.002 17.6 0.1 1.1 1 0 0 1 1 1 1 MalT-like TPR region BTAD PF03704.17 EFO65371.1 - 0.0015 18.9 1.2 0.016 15.7 1.2 2.0 1 1 1 2 2 2 1 Bacterial transcriptional activator domain TPR_6 PF13174.6 EFO65371.1 - 0.0021 18.6 0.2 4.8 8.0 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFO65371.1 - 0.0093 16.0 1.3 0.042 13.9 0.1 2.2 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 EFO65371.1 - 0.014 15.5 2.0 0.023 14.7 0.5 2.1 1 1 0 1 1 1 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 EFO65371.1 - 0.015 14.8 0.7 0.26 10.8 0.0 3.0 3 1 0 3 3 3 0 SHNi-TPR YfiO PF13525.6 EFO65371.1 - 0.016 15.0 0.1 0.025 14.3 0.1 1.4 1 1 0 1 1 1 0 Outer membrane lipoprotein TPR_5 PF12688.7 EFO65371.1 - 0.016 15.4 0.2 0.032 14.5 0.2 1.4 1 0 0 1 1 1 0 Tetratrico peptide repeat PPR PF01535.20 EFO65371.1 - 0.016 15.4 0.1 2.5 8.5 0.0 2.7 2 0 0 2 2 2 0 PPR repeat TPR_15 PF13429.6 EFO65371.1 - 0.028 13.6 0.3 1.2 8.2 0.0 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat SNAP PF14938.6 EFO65371.1 - 0.031 13.7 1.4 0.061 12.7 1.4 1.5 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPPII_N PF12583.8 EFO65371.1 - 0.034 14.7 0.0 0.059 14.0 0.0 1.4 1 1 0 1 1 1 0 Tripeptidyl peptidase II N terminal TPR_21 PF09976.9 EFO65371.1 - 0.036 13.8 1.8 0.78 9.4 0.1 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain TPR_17 PF13431.6 EFO65371.1 - 0.04 14.3 0.6 14 6.3 0.1 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 EFO65371.1 - 0.065 13.2 0.3 0.25 11.2 0.3 1.8 1 1 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal DUF3856 PF12968.7 EFO65371.1 - 0.074 13.1 2.1 0.18 11.9 0.5 2.2 2 1 0 2 2 2 0 Domain of Unknown Function (DUF3856) cobW PF02492.19 EFO65372.1 - 0.023 14.3 0.0 0.023 14.3 0.0 1.1 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain T6PP_N PF18572.1 EFO65372.1 - 0.057 13.3 0.0 0.09 12.6 0.0 1.4 1 0 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain Peptidase_U57 PF05582.12 EFO65372.1 - 0.1 11.8 0.1 0.12 11.6 0.1 1.1 1 0 0 1 1 1 0 YabG peptidase U57 LeuA_dimer PF08502.10 EFO65374.1 - 0.033 14.1 0.0 0.051 13.5 0.0 1.3 1 0 0 1 1 1 0 LeuA allosteric (dimerisation) domain NIF PF03031.18 EFO65375.1 - 1.1e-49 168.2 0.4 1.9e-49 167.4 0.4 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase FXR_C1 PF16096.5 EFO65375.1 - 2.3 8.5 7.9 0.74 10.1 1.9 2.4 1 1 1 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 RIIa PF02197.17 EFO65376.1 - 0.002 17.8 1.0 0.0034 17.0 1.0 1.4 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit MHB PF16525.5 EFO65376.1 - 0.018 15.3 0.0 0.03 14.6 0.0 1.5 1 1 0 1 1 1 0 Haemophore, haem-binding Microvir_H PF04687.12 EFO65376.1 - 0.13 11.6 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Microvirus H protein (pilot protein) Sec1 PF00995.23 EFO65377.1 - 2.3e-50 172.4 0.0 2.6e-50 172.2 0.0 1.0 1 0 0 1 1 1 1 Sec1 family APG6_N PF17675.1 EFO65377.1 - 1 9.9 5.1 3.2 8.3 5.1 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region FlgN PF05130.12 EFO65377.1 - 1.1 9.7 5.7 9.9 6.7 1.0 2.7 2 0 0 2 2 2 0 FlgN protein CLASP_N PF12348.8 EFO65378.1 - 4.7e-12 46.0 0.1 8.2e-12 45.2 0.1 1.3 1 0 0 1 1 1 1 CLASP N terminal RIIa PF02197.17 EFO65379.1 - 7.6e-07 28.7 0.0 1.6e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Filament PF00038.21 EFO65380.1 - 0.0013 18.4 20.3 0.0092 15.6 6.0 3.2 2 1 0 3 3 3 2 Intermediate filament protein Baculo_PEP_C PF04513.12 EFO65380.1 - 0.014 15.4 8.8 0.72 9.9 1.9 3.8 1 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus CdvA PF18822.1 EFO65380.1 - 0.022 14.6 12.6 0.18 11.6 4.5 4.3 2 2 1 4 4 4 0 CdvA-like coiled-coil domain SF-assemblin PF06705.11 EFO65380.1 - 0.049 13.0 11.4 0.98 8.7 6.1 3.5 1 1 1 3 3 3 0 SF-assemblin/beta giardin DUF16 PF01519.16 EFO65380.1 - 0.057 13.9 12.1 0.67 10.5 4.7 3.1 3 0 0 3 3 3 0 Protein of unknown function DUF16 DUF5309 PF17236.2 EFO65380.1 - 0.08 12.3 2.4 0.2 11.0 2.4 1.7 1 1 0 1 1 1 0 Family of unknown function (DUF5309) ZnuA PF01297.17 EFO65380.1 - 0.26 10.7 4.5 0.25 10.7 1.5 2.2 1 1 1 2 2 2 0 Zinc-uptake complex component A periplasmic Serine_rich PF08824.10 EFO65380.1 - 0.3 11.1 4.8 0.4 10.7 0.8 3.0 3 1 1 4 4 4 0 Serine rich protein interaction domain ApoO PF09769.9 EFO65380.1 - 0.3 11.0 2.1 66 3.5 0.1 3.3 2 1 1 3 3 3 0 Apolipoprotein O DUF1664 PF07889.12 EFO65380.1 - 0.6 10.1 10.9 4.5 7.3 3.7 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) FliD_C PF07195.12 EFO65380.1 - 0.79 9.1 11.6 4.1 6.8 5.1 2.9 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus ADIP PF11559.8 EFO65380.1 - 1.3 9.1 14.0 0.26 11.4 4.3 3.1 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Prominin PF05478.11 EFO65380.1 - 1.4 6.8 10.3 0.33 8.8 1.1 2.9 2 1 2 4 4 4 0 Prominin Exonuc_VII_L PF02601.15 EFO65380.1 - 1.6 8.3 12.9 42 3.6 12.9 2.2 1 1 0 1 1 1 0 Exonuclease VII, large subunit COG2 PF06148.11 EFO65380.1 - 1.8 8.6 10.9 7.5 6.6 0.1 3.9 2 2 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Fib_alpha PF08702.10 EFO65380.1 - 2 8.6 17.6 3.5 7.8 6.6 3.7 2 2 2 4 4 4 0 Fibrinogen alpha/beta chain family CHDCT2 PF08074.11 EFO65380.1 - 3.4 7.8 8.0 2.4 8.3 0.1 3.3 2 2 0 3 3 3 0 CHDCT2 (NUC038) domain Cut12 PF11500.8 EFO65380.1 - 4.8 7.1 9.4 0.82 9.6 0.2 3.0 3 0 0 3 3 3 0 Spindle pole body formation-associated protein Apolipoprotein PF01442.18 EFO65380.1 - 6.7 6.5 16.7 2.3 8.1 3.9 3.2 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain FlaC_arch PF05377.11 EFO65381.1 - 0.088 13.2 0.3 0.62 10.5 0.0 2.3 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF4558 PF15104.6 EFO65381.1 - 0.35 10.9 7.9 31 4.7 7.8 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4558) Sec7 PF01369.20 EFO65383.1 - 1.2e-31 109.8 2.3 4.5e-31 107.9 1.0 2.8 2 1 0 2 2 2 1 Sec7 domain N-glycanase_N PF09112.10 EFO65383.1 - 0.014 15.2 0.0 0.047 13.5 0.0 1.9 1 1 0 1 1 1 0 Peptide-N-glycosidase F, N terminal BCS1_N PF08740.11 EFO65383.1 - 0.02 14.9 0.0 11 5.9 0.0 2.8 2 0 0 2 2 2 0 BCS1 N terminal PUF PF00806.19 EFO65384.1 - 7.2e-38 126.2 11.6 1e-06 28.0 0.0 7.6 7 0 0 7 7 7 7 Pumilio-family RNA binding repeat MatE PF01554.18 EFO65385.1 - 3.1e-21 75.7 40.8 2e-16 60.0 19.4 2.6 2 0 0 2 2 2 2 MatE Peptidase_M24 PF00557.24 EFO65386.1 - 5.5e-54 183.0 0.1 7.1e-54 182.7 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EFO65386.1 - 2.7e-26 91.7 0.0 5.1e-26 90.8 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain VSP PF03302.13 EFO65387.1 - 2e-10 40.1 86.5 2e-10 40.1 86.5 12.3 2 2 6 10 10 10 7 Giardia variant-specific surface protein zf-RING_UBOX PF13445.6 EFO65388.1 - 1.6e-08 34.4 3.4 1.6e-08 34.4 3.4 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EFO65388.1 - 2.3e-07 30.8 7.0 5.2e-07 29.7 7.0 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EFO65388.1 - 5.5e-06 26.1 7.7 1e-05 25.3 7.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFO65388.1 - 9.8e-06 25.4 5.0 9.8e-06 25.4 5.0 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFO65388.1 - 1.7e-05 24.7 10.0 3.1e-05 23.8 10.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EFO65388.1 - 6.6e-05 22.7 7.2 0.00015 21.6 7.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EFO65388.1 - 0.00014 21.6 10.3 0.00064 19.5 8.5 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFO65388.1 - 0.0009 19.5 10.5 0.0013 19.0 9.5 1.8 2 0 0 2 2 2 1 Ring finger domain zf-RING_6 PF14835.6 EFO65388.1 - 0.051 13.5 3.9 0.089 12.7 3.9 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein DUF4634 PF15465.6 EFO65388.1 - 0.17 12.2 0.2 0.36 11.1 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4634) zf-RING_10 PF16685.5 EFO65388.1 - 0.69 10.1 9.7 1.8 8.7 9.8 1.7 1 1 0 1 1 1 0 zinc RING finger of MSL2 zf-rbx1 PF12678.7 EFO65388.1 - 0.84 10.0 5.9 2.4 8.5 5.9 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain PPI_Ypi1 PF07491.11 EFO65388.1 - 5.9 6.8 8.5 0.19 11.6 1.4 2.2 2 0 0 2 2 2 0 Protein phosphatase inhibitor ANAPC4_WD40 PF12894.7 EFO65391.1 - 5.6e-06 26.6 0.0 0.082 13.2 0.0 3.7 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFO65391.1 - 0.00012 22.7 0.3 0.053 14.4 0.0 4.6 4 0 0 4 4 4 1 WD domain, G-beta repeat DUF1668 PF07893.13 EFO65391.1 - 0.13 11.6 0.0 40 3.4 0.0 3.1 2 1 0 3 3 3 0 Protein of unknown function (DUF1668) NIF PF03031.18 EFO65392.1 - 8.1e-08 32.2 0.1 1.1e-06 28.6 0.1 2.5 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 EFO65392.1 - 0.043 14.2 0.2 0.47 10.9 0.0 2.7 4 0 0 4 4 4 0 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EFO65392.1 - 0.17 11.9 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 twin BRCT domain TAF1_subA PF14929.6 EFO65395.1 - 0.037 13.4 0.1 0.073 12.5 0.1 1.4 1 0 0 1 1 1 0 TAF RNA Polymerase I subunit A DUF4235 PF14019.6 EFO65396.1 - 0.042 13.9 2.8 0.082 13.0 2.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4235) Ribosomal_S9 PF00380.19 EFO65401.1 - 3.4e-29 101.8 0.6 3.4e-29 101.8 0.6 1.3 2 0 0 2 2 2 1 Ribosomal protein S9/S16 Serpin PF00079.20 EFO65402.1 - 1.8e-60 205.2 0.1 2.3e-60 204.9 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Kinesin PF00225.23 EFO65403.1 - 1.4e-113 379.2 0.2 1.4e-113 379.2 0.2 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFO65403.1 - 8.3e-26 90.7 0.5 2e-25 89.5 0.0 1.9 2 0 0 2 2 2 1 Microtubule binding Kinesin_assoc PF16183.5 EFO65403.1 - 0.00081 19.6 3.8 0.00081 19.6 3.8 2.6 1 1 1 2 2 2 1 Kinesin-associated DUF2730 PF10805.8 EFO65403.1 - 0.31 11.1 14.1 0.039 14.0 6.7 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF2730) DUF4200 PF13863.6 EFO65403.1 - 0.82 10.1 40.0 0.056 13.9 16.6 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) zf-C4H2 PF10146.9 EFO65403.1 - 6.4 7.0 21.1 0.13 12.5 10.8 2.6 2 1 0 2 2 2 0 Zinc finger-containing protein DUF4804 PF16062.5 EFO65405.1 - 2.5e-116 389.2 0.0 3.5e-116 388.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4804) CMS1 PF14617.6 EFO65406.1 - 7.2e-15 55.0 0.0 1.3e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit CENP-Q PF13094.6 EFO65406.1 - 0.055 13.7 0.0 0.089 13.0 0.0 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Kri1_C PF12936.7 EFO65407.1 - 3.3e-12 46.4 0.0 3.3e-12 46.4 0.0 2.5 2 1 0 2 2 2 1 KRI1-like family C-terminal Kri1 PF05178.12 EFO65407.1 - 2.8e-09 37.5 8.0 2.8e-09 37.5 8.0 3.2 2 1 2 4 4 4 1 KRI1-like family BCS1_N PF08740.11 EFO65407.1 - 0.048 13.6 6.1 0.68 9.9 0.1 2.5 2 0 0 2 2 2 0 BCS1 N terminal HemY_N PF07219.13 EFO65407.1 - 0.3 11.3 2.8 0.68 10.2 2.8 1.5 1 0 0 1 1 1 0 HemY protein N-terminus TOPRIM_C PF16898.5 EFO65407.1 - 0.68 10.2 6.1 0.14 12.4 0.3 2.6 1 1 1 2 2 2 0 C-terminal associated domain of TOPRIM FKBP_C PF00254.28 EFO65408.1 - 2.1e-25 88.8 0.0 4.4e-25 87.8 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Ank_2 PF12796.7 EFO65411.1 - 1.4e-16 60.9 0.0 9.1e-09 35.8 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO65411.1 - 7.4e-10 39.2 0.1 0.024 15.2 0.0 4.0 3 1 0 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO65411.1 - 2.9e-09 37.0 0.0 0.004 17.4 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65411.1 - 7.6e-06 25.9 0.2 0.49 11.1 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EFO65411.1 - 0.0018 18.7 1.7 0.29 11.6 0.1 3.7 4 0 0 4 4 4 1 Ankyrin repeat Poty_PP PF08440.10 EFO65411.1 - 0.0018 17.4 3.1 0.0026 16.9 3.1 1.2 1 0 0 1 1 1 1 Potyviridae polyprotein Prefoldin PF02996.17 EFO65411.1 - 1.7 8.6 5.7 4.6 7.2 0.2 3.0 1 1 2 3 3 3 0 Prefoldin subunit HSP90 PF00183.18 EFO65412.1 - 1.1e-71 242.3 22.8 1.3e-69 235.4 22.8 3.5 1 1 0 1 1 1 1 Hsp90 protein HATPase_c_3 PF13589.6 EFO65412.1 - 1.8e-10 40.8 0.0 5e-10 39.3 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFO65412.1 - 4.4e-08 33.6 0.0 9.1e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RabGAP-TBC PF00566.18 EFO65413.1 - 9.3e-31 107.1 0.0 1.2e-30 106.8 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Nop PF01798.18 EFO65414.1 - 1.2e-61 208.1 0.1 2.2e-61 207.3 0.1 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EFO65414.1 - 1.2e-12 48.1 0.6 3e-12 46.7 0.6 1.8 1 0 0 1 1 1 1 NOP5NT (NUC127) domain PhageMin_Tail PF10145.9 EFO65414.1 - 0.045 13.6 1.1 0.16 11.8 1.0 1.9 2 0 0 2 2 2 0 Phage-related minor tail protein Cytomega_UL84 PF06284.11 EFO65414.1 - 1.5 7.2 8.8 2.4 6.5 8.8 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Coilin_N PF15862.5 EFO65414.1 - 2.9 7.7 13.9 4.8 7.0 13.9 1.3 1 0 0 1 1 1 0 Coilin N-terminus SelP_N PF04592.14 EFO65414.1 - 5.2 6.4 13.7 7.5 5.9 13.7 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region TM2 PF05154.16 EFO65415.1 - 2.3e-19 69.5 13.7 2.9e-19 69.1 13.7 1.1 1 0 0 1 1 1 1 TM2 domain zf-LITAF-like PF10601.9 EFO65415.1 - 3.9 7.8 6.4 9.9 6.5 0.5 2.1 1 1 1 2 2 2 0 LITAF-like zinc ribbon domain PEP-CTERM PF07589.11 EFO65415.1 - 7.8 6.7 5.7 7 6.9 2.5 2.1 2 0 0 2 2 2 0 PEP-CTERM motif Spc7 PF08317.11 EFO65416.1 - 4.7e-06 25.7 8.3 4.7e-06 25.7 8.3 2.3 1 1 1 2 2 2 1 Spc7 kinetochore protein Myosin_tail_1 PF01576.19 EFO65416.1 - 0.0027 15.6 16.4 0.0037 15.2 16.4 1.0 1 0 0 1 1 1 1 Myosin tail IFT57 PF10498.9 EFO65416.1 - 0.022 13.7 16.9 0.012 14.6 5.2 2.4 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Prominin PF05478.11 EFO65416.1 - 0.04 11.9 7.3 0.068 11.1 7.3 1.3 1 0 0 1 1 1 0 Prominin Talin_middle PF09141.10 EFO65416.1 - 0.049 13.7 1.5 0.099 12.7 1.5 1.5 1 0 0 1 1 1 0 Talin, middle domain APG6_N PF17675.1 EFO65416.1 - 0.11 13.1 27.5 0.047 14.2 17.5 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF4201 PF13870.6 EFO65416.1 - 0.22 11.3 19.2 2 8.1 7.5 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Golgin_A5 PF09787.9 EFO65416.1 - 0.26 10.7 21.1 2.6 7.4 10.8 2.3 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF724 PF05266.14 EFO65416.1 - 0.26 11.1 17.1 0.045 13.6 3.7 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF724) PRKG1_interact PF15898.5 EFO65416.1 - 0.6 11.0 19.1 0.28 12.1 7.6 2.6 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain TPR_MLP1_2 PF07926.12 EFO65416.1 - 0.61 10.1 23.5 0.18 11.9 9.0 2.7 2 1 1 3 3 2 0 TPR/MLP1/MLP2-like protein THOC7 PF05615.13 EFO65416.1 - 0.81 10.0 16.2 0.43 10.9 13.4 1.9 1 1 1 2 2 2 0 Tho complex subunit 7 TMF_TATA_bd PF12325.8 EFO65416.1 - 1.2 9.4 21.6 0.44 10.8 0.4 4.1 1 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding GAS PF13851.6 EFO65416.1 - 1.3 8.4 24.8 2.6 7.3 7.1 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ERM PF00769.19 EFO65416.1 - 1.4 8.7 21.8 1.7 8.4 19.5 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family CENP-F_leu_zip PF10473.9 EFO65416.1 - 1.7 8.7 20.4 4.8 7.2 19.1 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CENP-H PF05837.12 EFO65416.1 - 2.2 8.7 18.0 0.92 9.9 7.9 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) OmpH PF03938.14 EFO65416.1 - 2.3 8.5 23.4 0.87 9.9 5.5 2.9 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) Fez1 PF06818.15 EFO65416.1 - 4 7.9 18.8 11 6.4 18.5 1.9 1 1 1 2 2 2 0 Fez1 KfrA_N PF11740.8 EFO65416.1 - 4.4 8.0 12.6 2.7 8.7 0.6 2.9 3 0 0 3 3 2 0 Plasmid replication region DNA-binding N-term ATG16 PF08614.11 EFO65416.1 - 4.6 7.4 22.5 2.7 8.2 10.7 2.5 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) HAUS-augmin3 PF14932.6 EFO65416.1 - 5.3 6.5 20.2 7.8 6.0 5.8 2.4 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Occludin_ELL PF07303.13 EFO65416.1 - 7.3 7.4 13.5 3.6 8.4 0.5 3.0 2 1 1 3 3 3 0 Occludin homology domain DUF848 PF05852.11 EFO65416.1 - 7.3 6.7 15.4 1 9.4 7.2 2.6 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) UPF0242 PF06785.11 EFO65416.1 - 8 6.5 24.0 6.7 6.8 5.4 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TMF_DNA_bd PF12329.8 EFO65418.1 - 0.0042 17.1 11.2 0.26 11.3 0.2 3.8 3 0 0 3 3 3 2 TATA element modulatory factor 1 DNA binding MscS_porin PF12795.7 EFO65418.1 - 0.026 14.1 0.5 0.026 14.1 0.5 3.7 4 0 0 4 4 4 0 Mechanosensitive ion channel porin domain AAA-ATPase_like PF09820.9 EFO65418.1 - 0.05 13.0 0.0 0.087 12.2 0.0 1.3 1 0 0 1 1 1 0 Predicted AAA-ATPase TMF_TATA_bd PF12325.8 EFO65418.1 - 0.092 13.0 10.4 1.3 9.2 0.2 3.4 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding SurA_N PF09312.11 EFO65418.1 - 0.36 10.9 3.3 0.55 10.3 0.3 2.6 2 1 0 2 2 2 0 SurA N-terminal domain SlyX PF04102.12 EFO65418.1 - 1.3 9.7 13.1 0.51 11.0 0.5 4.5 4 1 0 4 4 4 0 SlyX Baculo_PEP_C PF04513.12 EFO65418.1 - 3.1 7.8 19.0 0.5 10.4 4.4 3.9 2 2 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus USP8_interact PF08941.10 EFO65418.1 - 9.3 6.0 8.6 2.4 7.9 0.1 3.0 4 0 0 4 4 4 0 USP8 interacting TRAPPC-Trs85 PF12739.7 EFO65419.1 - 0.012 14.6 0.3 0.022 13.7 0.3 1.3 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TPR_7 PF13176.6 EFO65419.1 - 0.05 13.7 0.2 20 5.5 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Apolipoprotein PF01442.18 EFO65421.1 - 6.4 6.6 22.0 1.6 8.5 8.7 3.8 3 2 0 3 3 3 0 Apolipoprotein A1/A4/E domain DASH_Dad3 PF08656.10 EFO65421.1 - 9.7 6.4 11.1 4.4 7.5 0.1 4.9 4 0 0 4 4 4 0 DASH complex subunit Dad3 ORF11CD3 PF10549.9 EFO65422.1 - 0.44 10.7 8.2 0.78 9.9 0.0 4.6 4 0 0 4 4 4 0 ORF11CD3 domain TPR_14 PF13428.6 EFO65424.1 - 1.2e-12 47.5 8.1 0.0033 18.1 0.0 5.5 5 1 1 6 6 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFO65424.1 - 1.1e-11 45.1 5.8 2.7e-05 24.7 0.1 5.0 5 1 1 6 6 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFO65424.1 - 1.4e-11 43.6 17.3 0.0005 20.0 0.7 6.8 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFO65424.1 - 5.7e-10 39.6 19.5 2.1e-07 31.3 2.7 5.1 5 1 1 6 6 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFO65424.1 - 1.9e-09 37.6 12.1 2.7e-05 24.3 1.0 4.1 3 0 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EFO65424.1 - 2.2e-09 36.9 19.1 1.8e-06 27.5 2.0 4.4 4 1 0 4 4 4 2 TPR repeat TPR_12 PF13424.6 EFO65424.1 - 1.4e-06 28.5 12.8 0.0019 18.5 0.3 5.6 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFO65424.1 - 3.1e-06 26.8 7.0 2.1 8.6 0.0 5.7 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFO65424.1 - 4.4e-06 26.3 5.0 1.4e-05 24.7 1.0 6.4 6 1 1 7 7 6 2 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EFO65424.1 - 2e-05 24.6 1.3 0.17 11.9 0.0 3.9 3 1 1 4 4 4 1 Putative TPR-like repeat TPR_6 PF13174.6 EFO65424.1 - 2.4e-05 24.7 7.9 0.00098 19.6 0.0 5.6 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFO65424.1 - 0.00044 20.2 8.8 0.0096 16.1 0.6 5.5 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_20 PF14561.6 EFO65424.1 - 0.00066 20.0 2.3 0.029 14.7 0.1 3.6 2 2 1 3 3 3 1 Tetratricopeptide repeat NARP1 PF12569.8 EFO65424.1 - 0.0033 16.4 3.4 0.58 9.0 0.6 2.9 2 1 1 3 3 3 2 NMDA receptor-regulated protein 1 TPR_15 PF13429.6 EFO65424.1 - 0.0036 16.5 5.1 0.15 11.2 0.7 3.5 3 1 1 4 4 4 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EFO65424.1 - 0.0046 16.6 0.6 0.037 13.7 0.0 2.7 2 1 1 3 3 3 1 Bacterial type III secretion protein (HrpB1_HrpK) Fis1_TPR_C PF14853.6 EFO65424.1 - 0.006 16.6 12.7 2.9 8.0 0.1 6.1 4 1 2 6 6 6 1 Fis1 C-terminal tetratricopeptide repeat BTAD PF03704.17 EFO65424.1 - 0.0062 17.0 5.6 0.063 13.7 1.4 3.3 2 1 1 3 3 3 2 Bacterial transcriptional activator domain YfiO PF13525.6 EFO65424.1 - 0.0067 16.2 2.3 0.79 9.4 0.2 3.6 3 1 0 4 4 3 1 Outer membrane lipoprotein SHNi-TPR PF10516.9 EFO65424.1 - 0.016 14.6 1.1 0.36 10.3 0.0 3.2 3 0 0 3 3 3 0 SHNi-TPR PPR PF01535.20 EFO65424.1 - 0.028 14.7 0.2 49 4.5 0.0 4.9 5 0 0 5 5 4 0 PPR repeat TPR_21 PF09976.9 EFO65424.1 - 0.063 13.0 2.6 14 5.3 0.0 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat-like domain TPR_3 PF07720.12 EFO65424.1 - 0.11 12.6 2.0 2.6 8.1 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 EFO65424.1 - 0.27 11.3 4.9 11 6.2 0.2 3.1 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain SNAP PF14938.6 EFO65424.1 - 0.59 9.5 10.0 2.4 7.5 0.7 3.5 4 1 0 4 4 4 0 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 EFO65424.1 - 1.6 9.3 9.8 30 5.3 0.0 5.1 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFO65424.1 - 6.1 6.9 9.1 7.1 6.6 0.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat SNF2_N PF00176.23 EFO65427.1 - 5.4e-43 147.1 1.0 9.3e-43 146.3 0.0 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFO65427.1 - 1.7e-14 54.1 0.0 5e-14 52.6 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFO65427.1 - 5e-10 39.6 0.1 2.4e-09 37.4 0.0 2.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit zf-Mss51 PF13824.6 EFO65429.1 - 0.1 12.7 0.3 0.3 11.2 0.3 1.8 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 VSP PF03302.13 EFO65430.1 - 4.4e-68 229.9 100.3 3.3e-37 128.3 30.1 5.0 1 1 3 4 4 4 3 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO65430.1 - 0.0047 17.0 0.4 0.015 15.4 0.0 2.0 2 0 0 2 2 2 1 Podoplanin SKG6 PF08693.10 EFO65430.1 - 0.53 9.7 4.1 0.91 9.0 4.1 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain VSP PF03302.13 EFO65431.1 - 8.6e-51 173.0 154.6 3.5e-37 128.2 90.4 6.1 1 1 4 5 5 5 5 Giardia variant-specific surface protein SKG6 PF08693.10 EFO65431.1 - 0.096 12.1 0.6 0.17 11.3 0.6 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Peptidase_C1 PF00112.23 EFO65432.1 - 2.4e-26 93.2 0.2 2.6e-26 93.1 0.2 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFO65432.1 - 0.0012 17.7 0.0 0.0015 17.4 0.0 1.0 1 0 0 1 1 1 1 Peptidase C1-like family GntR PF00392.21 EFO65433.1 - 0.013 15.1 0.1 0.025 14.2 0.1 1.6 1 1 0 1 1 1 0 Bacterial regulatory proteins, gntR family Ribosomal_60s PF00428.19 EFO65436.1 - 2.5e-11 44.0 11.3 3.4e-11 43.6 11.3 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein Peptidase_C12 PF01088.21 EFO65436.1 - 0.06 13.1 0.0 0.078 12.7 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase, family 1 DFRP_C PF16543.5 EFO65437.1 - 5.9e-10 39.5 7.6 5.9e-10 39.5 7.6 3.7 3 2 1 4 4 4 1 DRG Family Regulatory Proteins, Tma46 Torus PF16131.5 EFO65437.1 - 0.0065 17.2 7.7 0.0065 17.2 7.7 3.7 3 2 0 3 3 3 1 Torus domain zf-CCCH_4 PF18044.1 EFO65437.1 - 0.011 15.5 7.7 0.011 15.5 7.7 2.9 4 0 0 4 4 4 0 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EFO65437.1 - 0.03 14.6 1.6 0.03 14.6 1.6 2.9 3 0 0 3 3 3 0 Zinc-finger containing family Sec16 PF12932.7 EFO65437.1 - 0.22 12.1 6.1 3.6 8.2 2.6 2.7 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region zf_CCCH_4 PF18345.1 EFO65437.1 - 1 9.5 13.0 0.16 12.1 7.9 2.3 2 0 0 2 2 2 0 Zinc finger domain PPTA PF01239.22 EFO65438.1 - 6.9e-19 66.9 7.7 7.4e-05 22.3 0.1 4.5 4 0 0 4 4 4 4 Protein prenyltransferase alpha subunit repeat Retrotran_gag_3 PF14244.6 EFO65438.1 - 0.12 12.2 0.1 1.1 9.1 0.1 2.5 3 0 0 3 3 3 0 gag-polypeptide of LTR copia-type PhoLip_ATPase_C PF16212.5 EFO65439.1 - 7.1e-45 153.7 12.5 7.1e-45 153.7 12.5 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFO65439.1 - 2.6e-13 49.5 7.0 6e-13 48.3 7.0 1.6 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFO65439.1 - 5.5e-09 36.0 0.0 1.6e-08 34.5 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EFO65439.1 - 6.6e-09 35.5 0.0 5.9e-07 29.2 0.0 3.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFO65439.1 - 1.5e-08 35.2 0.7 0.0004 20.7 0.0 3.6 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFO65439.1 - 0.0057 16.4 0.0 0.031 14.0 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF5470 PF17564.2 EFO65439.1 - 0.26 11.5 1.2 1 9.6 1.2 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5470) Actin PF00022.19 EFO65440.1 - 8.6e-24 83.9 0.2 5.6e-17 61.4 0.2 3.5 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.13 EFO65440.1 - 0.00018 20.5 0.4 0.24 10.2 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein zf-RING_UBOX PF13445.6 EFO65440.1 - 0.03 14.3 2.6 2.2 8.4 0.0 3.3 3 0 0 3 3 3 0 RING-type zinc-finger NUC202 PF08166.12 EFO65440.1 - 0.12 12.5 0.5 14 5.8 0.1 2.8 2 1 0 2 2 2 0 NUC202 domain Ribophorin_I PF04597.14 EFO65441.1 - 1.7e-21 76.9 0.3 5.1e-20 72.1 0.4 2.0 2 0 0 2 2 2 2 Ribophorin I N_NLPC_P60 PF12912.7 EFO65443.1 - 0.039 14.3 0.1 0.068 13.5 0.1 1.3 1 0 0 1 1 1 0 NLPC_P60 stabilising domain, N term SF-assemblin PF06705.11 EFO65444.1 - 2.6e-08 33.5 25.3 5.4e-08 32.5 21.7 2.1 1 1 1 2 2 2 1 SF-assemblin/beta giardin Cor1 PF04803.12 EFO65444.1 - 0.013 15.8 4.9 0.013 15.8 4.9 2.5 1 1 1 2 2 2 0 Cor1/Xlr/Xmr conserved region Baculo_PEP_C PF04513.12 EFO65444.1 - 0.84 9.7 13.5 0.94 9.5 6.3 3.4 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus RNA_pol_Rbc25 PF08292.12 EFO65444.1 - 6.4 7.0 6.5 0.85 9.9 1.6 2.0 1 1 1 2 2 2 0 RNA polymerase III subunit Rpc25 Ank_2 PF12796.7 EFO65445.1 - 2.2e-24 85.8 0.1 4.9e-12 46.3 0.1 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) zf-C3HC4_3 PF13920.6 EFO65445.1 - 6.4e-13 48.3 12.5 1.3e-12 47.3 12.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Ank PF00023.30 EFO65445.1 - 2.1e-12 46.9 0.2 0.081 13.4 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EFO65445.1 - 1.2e-11 43.7 0.2 0.5 11.1 0.0 5.9 5 1 0 6 6 6 3 Ankyrin repeat Ank_4 PF13637.6 EFO65445.1 - 1.3e-11 44.7 0.7 0.12 13.0 0.0 4.8 4 1 0 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO65445.1 - 4.2e-11 42.9 0.7 0.0017 18.6 0.0 4.7 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Prok-RING_4 PF14447.6 EFO65445.1 - 9.6e-08 31.8 11.7 2e-07 30.8 11.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFO65445.1 - 7.4e-07 29.4 14.4 1.7e-06 28.3 14.4 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFO65445.1 - 1.1e-06 28.3 14.2 1.1e-06 28.3 14.2 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFO65445.1 - 5.7e-06 26.2 11.8 1.6e-05 24.7 11.8 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFO65445.1 - 0.0021 17.9 14.0 0.0021 17.9 14.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFO65445.1 - 0.016 15.2 9.4 0.018 15.0 6.1 2.5 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EFO65445.1 - 0.056 13.6 10.3 0.33 11.1 10.6 2.2 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EFO65445.1 - 3.4 8.0 12.4 2.6 8.4 10.6 1.7 2 0 0 2 2 1 0 RING-H2 zinc finger domain DUF1644 PF07800.12 EFO65445.1 - 7.8 6.5 8.7 2.5 8.1 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) Brix PF04427.18 EFO65446.1 - 7.4e-29 101.2 0.1 1e-28 100.8 0.1 1.2 1 0 0 1 1 1 1 Brix domain PRTP PF01366.18 EFO65446.1 - 0.13 10.3 0.1 0.17 9.9 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein HSP70 PF00012.20 EFO65449.1 - 1.8e-241 802.6 3.3 2.2e-241 802.3 3.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFO65449.1 - 1.3e-16 60.4 0.0 5.1e-15 55.1 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 EFO65449.1 - 0.0077 16.6 0.5 15 6.1 0.0 3.5 3 1 0 3 3 3 2 Cell division protein FtsA CPBP PF02517.16 EFO65450.1 - 1.2e-07 32.0 3.5 1.7e-07 31.5 3.5 1.3 1 0 0 1 1 1 1 CPBP intramembrane metalloprotease Cytadhesin_P30 PF07271.11 EFO65450.1 - 0.027 14.0 0.3 0.033 13.7 0.3 1.1 1 0 0 1 1 1 0 Cytadhesin P30/P32 LRR_9 PF14580.6 EFO65451.1 - 3.9e-19 68.8 4.0 6.4e-19 68.1 4.0 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EFO65451.1 - 4.6e-11 42.8 11.2 8.4e-06 26.0 6.9 3.8 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO65451.1 - 5.6e-07 29.2 12.1 0.0008 19.1 0.5 2.7 1 1 1 2 2 2 2 Leucine rich repeat PIH1_CS PF18201.1 EFO65451.1 - 0.074 13.5 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 PIH1 CS-like domain AAA_13 PF13166.6 EFO65452.1 - 0.00041 19.2 34.7 0.00041 19.2 34.7 4.9 1 1 4 5 5 5 2 AAA domain Cep57_CLD_2 PF14197.6 EFO65452.1 - 0.0029 17.7 4.0 0.0029 17.7 4.0 11.5 8 2 3 11 11 11 1 Centrosome localisation domain of PPC89 ATG16 PF08614.11 EFO65452.1 - 0.014 15.6 146.4 0.057 13.6 31.3 8.3 4 1 4 8 8 8 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 EFO65452.1 - 1.4 9.3 119.4 0.84 10.1 3.0 6.9 1 1 5 7 7 7 0 Fez1 NTS PF15447.6 EFO65452.1 - 5.1 7.7 7.1 12 6.5 0.1 3.6 3 0 0 3 3 3 0 N-terminal segments of PfEMP1 Piwi PF02171.17 EFO65454.1 - 6.7e-39 133.9 0.0 1.3e-38 133.0 0.0 1.4 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 EFO65454.1 - 4.4e-07 29.8 0.1 8.9e-07 28.8 0.1 1.4 1 0 0 1 1 1 1 PAZ domain Peptidase_S9 PF00326.21 EFO65456.1 - 1.6e-37 129.1 1.1 2.5e-37 128.4 1.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EFO65456.1 - 0.0011 18.7 0.6 0.37 10.3 0.0 2.3 1 1 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.20 EFO65456.1 - 0.0012 18.6 0.9 0.4 10.3 0.3 2.4 1 1 1 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.18 EFO65456.1 - 0.0035 16.9 0.0 0.019 14.6 0.0 2.1 1 1 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 EFO65456.1 - 0.0097 15.9 0.1 0.042 13.8 0.1 1.9 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Nitroreductase PF00881.24 EFO65459.1 - 1.4e-28 100.1 0.0 1.7e-28 99.8 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family Fer4 PF00037.27 EFO65459.1 - 9.7e-12 44.2 12.1 1.8e-06 27.5 2.3 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 EFO65459.1 - 1.3e-09 38.1 10.5 2.2e-09 37.3 10.5 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EFO65459.1 - 2.5e-09 37.6 13.0 4.8e-09 36.7 13.0 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 EFO65459.1 - 9.2e-09 35.0 11.8 2.1e-05 24.4 1.9 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 EFO65459.1 - 3.6e-08 33.4 22.2 4.2e-07 30.0 12.4 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 EFO65459.1 - 1.5e-07 31.4 14.0 0.0004 20.4 5.0 2.5 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_16 PF13484.6 EFO65459.1 - 1.6e-07 32.2 8.9 0.00034 21.5 1.7 2.4 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_2 PF12797.7 EFO65459.1 - 2.8e-06 27.1 14.6 4.3e-05 23.4 3.5 2.6 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.6 EFO65459.1 - 0.00014 22.4 12.6 0.036 14.6 2.7 2.5 1 1 1 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_8 PF13183.6 EFO65459.1 - 0.00016 22.1 9.0 0.083 13.4 3.3 2.4 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.7 EFO65459.1 - 0.0035 18.2 19.3 0.13 13.3 7.1 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 EFO65459.1 - 0.0053 17.2 12.5 0.018 15.5 2.2 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_17 PF13534.6 EFO65459.1 - 0.0061 17.1 12.5 0.91 10.1 12.3 2.4 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_22 PF17179.4 EFO65459.1 - 0.0079 17.0 7.9 0.72 10.7 0.7 2.4 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_15 PF13459.6 EFO65459.1 - 0.015 16.0 12.2 0.15 12.8 2.5 2.6 1 1 1 2 2 2 0 4Fe-4S single cluster domain Fer4_18 PF13746.6 EFO65459.1 - 0.02 15.1 12.9 0.58 10.4 4.5 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain ETF_QO PF05187.13 EFO65459.1 - 0.64 10.2 3.0 1.2 9.3 3.0 1.4 1 0 0 1 1 1 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Chorein_N PF12624.7 EFO65460.1 - 4.2e-18 65.6 1.0 1.4e-17 63.9 0.3 2.4 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 VPS13_C PF16909.5 EFO65460.1 - 8.6e-06 25.6 2.7 8.6e-06 25.6 2.7 5.8 5 1 0 5 5 5 2 Vacuolar-sorting-associated 13 protein C-terminal VSP PF03302.13 EFO65462.1 - 6e-145 483.0 163.2 3.6e-139 464.0 107.9 2.7 1 1 0 2 2 2 2 Giardia variant-specific surface protein AAA_11 PF13086.6 EFO65463.1 - 5.1e-11 42.9 0.0 1.1e-09 38.5 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.6 EFO65463.1 - 4.7e-09 36.2 0.0 3.5e-08 33.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFO65463.1 - 1.3e-07 31.5 0.0 0.044 13.5 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EFO65463.1 - 9.3e-07 29.3 0.0 1.4e-05 25.5 0.0 2.5 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EFO65463.1 - 1.4e-06 28.2 0.4 0.033 13.9 0.0 3.7 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EFO65463.1 - 0.0025 18.1 0.3 0.83 9.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain Hemerythrin PF01814.23 EFO65464.1 - 0.016 15.8 0.3 1.2 9.8 0.1 2.6 2 1 0 2 2 2 0 Hemerythrin HHE cation binding domain DUF5344 PF17279.2 EFO65464.1 - 0.032 14.8 4.6 0.11 13.1 3.8 2.2 3 0 0 3 3 3 0 Family of unknown function (DUF5344) MazG_C PF18722.1 EFO65464.1 - 0.067 12.7 0.3 0.096 12.2 0.3 1.2 1 0 0 1 1 1 0 MazG C-terminal domain DUF4242 PF14026.6 EFO65464.1 - 0.083 13.1 0.1 0.15 12.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4242) Acetyltransf_7 PF13508.7 EFO65465.1 - 6.3e-07 29.7 0.0 1e-06 29.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFO65465.1 - 1.2e-06 28.5 0.0 1.5e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFO65465.1 - 0.00073 19.8 0.0 0.001 19.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family RIB43A PF05914.12 EFO65466.1 - 6e-49 166.8 48.4 1.6e-46 158.8 48.4 2.0 1 1 0 1 1 1 1 RIB43A Porin_3 PF01459.22 EFO65467.1 - 4.7e-06 26.3 0.1 0.00023 20.8 0.0 3.3 1 1 0 1 1 1 1 Eukaryotic porin WD40 PF00400.32 EFO65468.1 - 1.2e-07 32.2 11.9 2.4e-05 25.0 0.0 5.4 6 0 0 6 6 6 2 WD domain, G-beta repeat RAB3GAP2_N PF14655.6 EFO65468.1 - 3e-05 23.5 0.1 9.1e-05 21.9 0.0 1.8 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus ANAPC4_WD40 PF12894.7 EFO65468.1 - 0.004 17.4 0.0 12 6.3 0.0 3.8 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF5047 PF16466.5 EFO65468.1 - 0.082 13.3 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5047) Pro_isomerase PF00160.21 EFO65469.1 - 2.6e-50 170.8 0.3 2.9e-50 170.6 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Sec23_trunk PF04811.15 EFO65470.1 - 3.5e-25 89.0 0.0 3.9e-21 75.7 0.0 3.1 2 1 1 3 3 3 2 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EFO65470.1 - 9.3e-13 48.7 0.0 2.9e-12 47.2 0.0 1.9 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EFO65470.1 - 8.4e-08 32.1 8.5 2.4e-07 30.7 8.5 1.9 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 EFO65470.1 - 3.1e-07 30.1 1.6 7.9e-07 28.8 0.5 2.4 2 1 0 2 2 2 1 Sec23/Sec24 helical domain ABC_tran PF00005.27 EFO65471.1 - 3.1e-18 66.6 0.0 5.8e-18 65.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 EFO65471.1 - 0.00074 19.5 0.2 0.0017 18.3 0.2 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_23 PF13476.6 EFO65471.1 - 0.075 13.5 0.1 0.18 12.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFO65471.1 - 0.095 13.1 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EFO65471.1 - 0.15 11.8 0.1 0.33 10.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain CKS PF01111.19 EFO65474.1 - 2e-33 114.4 4.7 2.3e-33 114.3 4.7 1.0 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Methuselah_N PF06652.12 EFO65474.1 - 0.0083 16.1 0.5 0.011 15.7 0.5 1.1 1 0 0 1 1 1 1 Methuselah N-terminus DUF1965 PF09248.10 EFO65474.1 - 0.028 14.2 1.6 0.072 12.9 0.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1965) ATP_bind_3 PF01171.20 EFO65476.1 - 1.2e-14 54.5 0.0 1.7e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 PP-loop family Diphthami_syn_2 PF01902.17 EFO65476.1 - 0.16 11.5 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Diphthamide synthase Spec3 PF15795.5 EFO65479.1 - 2.5e-08 34.4 7.8 4.8e-07 30.2 7.8 2.1 1 1 0 1 1 1 1 Ectodermal ciliogenesis protein Ank_2 PF12796.7 EFO65480.1 - 4.5e-87 286.7 36.4 1.5e-10 41.5 1.2 14.0 7 4 5 14 14 14 14 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO65480.1 - 9.9e-44 147.2 32.2 0.00012 22.6 0.0 19.4 15 4 6 21 21 21 13 Ankyrin repeats (many copies) Ank PF00023.30 EFO65480.1 - 1.5e-39 132.7 40.1 0.0028 18.0 0.0 20.5 19 2 1 20 20 20 12 Ankyrin repeat Ank_5 PF13857.6 EFO65480.1 - 7.6e-38 128.1 38.6 0.0026 18.0 0.1 17.8 14 3 4 18 18 18 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65480.1 - 1.5e-34 114.1 30.5 0.087 13.4 0.0 21.1 22 0 0 22 22 22 8 Ankyrin repeat Spec3 PF15795.5 EFO65481.1 - 2.1e-07 31.3 16.2 3.2e-06 27.6 16.2 2.0 1 1 0 1 1 1 1 Ectodermal ciliogenesis protein DUF3169 PF11368.8 EFO65481.1 - 0.0084 15.7 0.7 0.0092 15.5 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3169) PsaX PF08078.12 EFO65481.1 - 0.072 13.1 0.8 0.14 12.1 0.0 1.9 2 0 0 2 2 2 0 PsaX family DctM PF06808.12 EFO65481.1 - 0.25 10.1 3.8 0.32 9.8 3.8 1.0 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporter, DctM component Ank_2 PF12796.7 EFO65482.1 - 4.8e-65 216.2 16.2 2.3e-15 57.0 1.1 6.9 1 1 6 7 7 7 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO65482.1 - 1.1e-38 130.8 18.0 0.00019 21.6 0.0 10.7 5 4 6 11 11 11 9 Ankyrin repeats (many copies) Ank PF00023.30 EFO65482.1 - 1.9e-30 103.9 9.4 0.0018 18.6 0.0 11.2 10 1 0 10 10 10 7 Ankyrin repeat Ank_3 PF13606.6 EFO65482.1 - 2.8e-30 100.9 12.6 0.037 14.6 0.1 12.7 13 0 0 13 13 13 7 Ankyrin repeat Ank_4 PF13637.6 EFO65482.1 - 3.8e-30 103.9 7.3 2.2e-07 31.3 0.2 8.5 5 3 5 10 10 10 9 Ankyrin repeats (many copies) AMP-binding PF00501.28 EFO65483.1 - 5.6e-38 130.6 0.0 9.2e-20 70.6 0.0 3.9 3 1 0 3 3 3 3 AMP-binding enzyme Cyclin_C_2 PF16899.5 EFO65486.1 - 0.063 13.7 0.1 0.22 11.9 0.1 2.1 1 0 0 1 1 1 0 Cyclin C-terminal domain EF-hand_2 PF09068.11 EFO65486.1 - 0.14 12.3 0.4 0.46 10.6 0.2 2.0 2 0 0 2 2 2 0 EF hand AMP-binding PF00501.28 EFO65487.1 - 3.5e-25 88.5 0.5 1.7e-13 50.0 0.0 4.8 4 1 0 4 4 4 4 AMP-binding enzyme RuvB_C PF05491.13 EFO65487.1 - 0.081 12.8 0.3 2.2 8.2 0.0 3.0 3 0 0 3 3 3 0 RuvB C-terminal winged helix domain DUF1736 PF08409.11 EFO65489.1 - 0.28 11.2 1.6 3.4 7.7 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1736) Metallophos PF00149.28 EFO65490.1 - 8.4e-15 55.8 0.5 2.9e-14 54.1 0.5 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFO65490.1 - 0.00034 20.8 0.1 0.0051 17.0 0.0 2.1 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Pur_ac_phosph_N PF16656.5 EFO65490.1 - 0.018 15.6 0.0 0.048 14.2 0.0 1.7 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain PhoD_N PF16655.5 EFO65490.1 - 0.033 14.7 0.1 0.076 13.6 0.1 1.5 1 0 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain Diphthamide_syn PF01866.17 EFO65491.1 - 1.4e-07 31.3 0.0 2.4e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Putative diphthamide synthesis protein SET PF00856.28 EFO65492.1 - 1.4e-18 67.9 0.7 6.8e-18 65.6 0.7 2.1 1 1 0 1 1 1 1 SET domain DUF4326 PF14216.6 EFO65492.1 - 0.69 10.7 3.0 0.94 10.2 1.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4326) VSP PF03302.13 EFO65495.1 - 4e-32 111.6 36.8 2.8e-26 92.3 10.0 2.1 1 1 1 2 2 2 2 Giardia variant-specific surface protein NinF PF05810.12 EFO65495.1 - 0.44 10.4 7.0 1.4 8.9 0.3 3.1 3 0 0 3 3 3 0 NinF protein Podoplanin PF05808.11 EFO65495.1 - 0.47 10.6 3.6 1.5 8.9 3.7 1.8 1 1 0 1 1 1 0 Podoplanin DUF4804 PF16062.5 EFO65496.1 - 1.9e-138 462.0 0.0 2.6e-138 461.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4804) ABC_tran PF00005.27 EFO65497.1 - 8.7e-24 84.6 0.0 1.5e-23 83.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFO65497.1 - 2.6e-10 40.6 0.0 2.8e-06 27.4 0.0 2.5 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFO65497.1 - 0.0001 21.8 0.1 0.16 11.4 0.1 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain NB-ARC PF00931.22 EFO65497.1 - 0.013 14.7 0.0 0.077 12.2 0.0 2.0 1 1 0 1 1 1 0 NB-ARC domain AAA_29 PF13555.6 EFO65497.1 - 0.021 14.6 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EFO65497.1 - 0.034 14.7 0.1 0.061 13.8 0.1 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EFO65497.1 - 0.061 13.2 0.0 0.17 11.8 0.0 1.8 2 0 0 2 2 2 0 NACHT domain AAA_15 PF13175.6 EFO65497.1 - 0.086 12.5 0.1 0.14 11.8 0.1 1.2 1 0 0 1 1 1 0 AAA ATPase domain Ribosomal_L7Ae PF01248.26 EFO65499.1 - 5.1e-23 80.6 0.1 8.6e-23 79.9 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family CorA PF01544.18 EFO65500.1 - 0.0012 18.3 0.5 0.0021 17.4 0.5 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF2207 PF09972.9 EFO65500.1 - 0.0054 15.6 0.4 0.007 15.2 0.4 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Baseplate PF16774.5 EFO65500.1 - 0.015 15.2 2.4 1.5 8.7 0.1 3.0 3 0 0 3 3 3 0 Baseplate protein TMEM252 PF15664.5 EFO65500.1 - 0.065 12.9 0.1 0.18 11.5 0.1 1.8 1 0 0 1 1 1 0 Transmembrane protein 252 family Tubulin PF00091.25 EFO65501.1 - 2e-39 135.9 0.0 3.7e-39 135.0 0.0 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 EFO65501.1 - 0.019 14.2 0.1 0.048 12.8 0.0 1.6 2 0 0 2 2 2 0 Tubulin like Arf PF00025.21 EFO65502.1 - 9.9e-54 181.4 0.1 1.1e-53 181.3 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFO65502.1 - 2.6e-14 53.5 0.0 4e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFO65502.1 - 1.7e-13 50.5 0.0 1.9e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFO65502.1 - 7.4e-12 45.1 0.0 6.8e-09 35.3 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EFO65502.1 - 2.1e-10 40.3 0.0 2.5e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFO65502.1 - 4.4e-06 26.2 0.0 5.2e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFO65502.1 - 2.7e-05 24.2 0.1 0.00011 22.3 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EFO65502.1 - 0.00024 20.5 0.0 0.00038 19.8 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase TsaE PF02367.17 EFO65502.1 - 0.00047 20.1 0.0 0.00071 19.6 0.0 1.2 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EFO65502.1 - 0.034 14.1 0.0 1.2 9.0 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 EFO65502.1 - 0.042 14.0 0.2 0.15 12.3 0.1 1.8 1 1 0 2 2 2 0 AAA domain DUF872 PF05915.12 EFO65504.1 - 0.062 13.5 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) DUF3626 PF12294.8 EFO65505.1 - 0.00051 19.2 0.2 0.0008 18.6 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3626) DUF4527 PF15030.6 EFO65505.1 - 0.12 11.7 0.1 0.2 11.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) CENP-F_leu_zip PF10473.9 EFO65505.1 - 0.14 12.2 0.4 0.82 9.7 0.3 2.0 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fzo_mitofusin PF04799.13 EFO65505.1 - 1.4 8.4 4.9 0.17 11.4 0.1 2.0 3 0 0 3 3 3 0 fzo-like conserved region DUF2205 PF10224.9 EFO65506.1 - 2.7 8.1 12.1 0.067 13.2 3.9 2.7 2 0 0 2 2 2 0 Short coiled-coil protein Terminase_3C PF17288.2 EFO65506.1 - 3.3 8.1 9.9 2 8.8 5.1 2.5 2 1 0 2 2 2 0 Terminase RNAseH like domain DUF4248 PF14053.6 EFO65506.1 - 3.8 7.6 5.4 9.1 6.4 0.1 3.5 3 2 1 4 4 4 0 Domain of unknown function (DUF4248) Med9 PF07544.13 EFO65506.1 - 4.6 7.4 14.5 0.21 11.7 6.4 3.0 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF948 PF06103.11 EFO65506.1 - 7 7.0 11.3 0.85 9.9 2.3 3.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) HAP1_N PF04849.13 EFO65507.1 - 0.0013 18.0 10.1 0.0018 17.6 10.1 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region DUF724 PF05266.14 EFO65507.1 - 0.016 15.0 4.0 0.059 13.2 3.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF1664 PF07889.12 EFO65507.1 - 0.083 12.9 1.9 0.15 12.1 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 EFO65507.1 - 0.089 12.3 0.6 0.11 12.0 0.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FapA PF03961.13 EFO65507.1 - 0.14 10.8 0.3 0.18 10.4 0.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4201 PF13870.6 EFO65507.1 - 1 9.1 10.2 1.9 8.2 10.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) Nup54 PF13874.6 EFO65507.1 - 2.8 8.1 9.5 12 6.0 0.1 2.4 1 1 0 2 2 2 0 Nucleoporin complex subunit 54 ADIP PF11559.8 EFO65507.1 - 4.2 7.4 12.8 1 9.4 8.2 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Ank_2 PF12796.7 EFO65510.1 - 1.8e-64 214.3 12.1 7.9e-18 64.8 0.2 6.9 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO65510.1 - 4.3e-37 126.0 6.9 3.6e-07 30.6 0.0 10.1 5 2 6 11 11 11 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO65510.1 - 1.2e-32 111.5 16.4 3.1e-05 24.2 0.0 11.5 2 2 11 13 13 13 9 Ankyrin repeats (many copies) Ank PF00023.30 EFO65510.1 - 4.4e-32 109.1 12.3 0.0062 16.9 0.0 11.8 12 0 0 12 12 12 9 Ankyrin repeat Ank_3 PF13606.6 EFO65510.1 - 3.5e-31 103.7 10.1 0.0032 17.8 0.0 13.0 12 1 1 13 13 13 6 Ankyrin repeat Pkinase PF00069.25 EFO65510.1 - 1.6e-18 67.1 0.0 2.9e-17 62.9 0.0 2.3 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65510.1 - 9.2e-11 41.5 0.0 2.5e-10 40.1 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase DivIC PF04977.15 EFO65510.1 - 0.012 15.4 0.1 0.034 13.9 0.1 1.7 1 0 0 1 1 1 0 Septum formation initiator PK_C PF02887.16 EFO65510.1 - 0.13 12.5 0.1 2 8.7 0.0 3.0 2 1 0 2 2 2 0 Pyruvate kinase, alpha/beta domain Urocanase PF01175.18 EFO65511.1 - 0.053 13.2 0.1 0.094 12.4 0.1 1.4 1 0 0 1 1 1 0 Urocanase Rossmann-like domain Peptidase_C1 PF00112.23 EFO65512.1 - 4.7e-15 56.3 0.0 1.1e-14 55.0 0.0 1.5 1 1 0 1 1 1 1 Papain family cysteine protease CathepsinC_exc PF08773.11 EFO65512.1 - 2.1e-10 40.9 0.0 3.4e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Cathepsin C exclusion domain Ank_2 PF12796.7 EFO65513.1 - 7.8e-34 116.1 3.1 6.7e-16 58.7 0.1 2.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO65513.1 - 1.7e-28 99.7 0.0 2.5e-28 99.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65513.1 - 3.6e-21 75.6 0.0 6e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_5 PF13857.6 EFO65513.1 - 8.7e-14 51.4 0.2 0.00028 21.1 0.0 5.0 3 1 3 6 6 6 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO65513.1 - 1.9e-12 47.4 0.1 6.9e-06 26.5 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO65513.1 - 6.4e-09 35.9 0.2 0.0032 17.8 0.0 3.9 2 1 1 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 EFO65513.1 - 0.00018 21.7 0.2 1 10.1 0.0 3.8 3 0 0 3 3 3 1 Ankyrin repeat Haspin_kinase PF12330.8 EFO65513.1 - 0.029 13.3 0.0 0.049 12.6 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Nup88 PF10168.9 EFO65514.1 - 0.00085 17.3 17.8 0.00096 17.1 17.0 1.4 2 0 0 2 2 2 1 Nuclear pore component Fib_alpha PF08702.10 EFO65514.1 - 0.026 14.7 17.2 0.19 11.9 4.4 2.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 EFO65514.1 - 0.092 12.8 18.2 0.35 10.9 3.0 3.8 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) TSC22 PF01166.18 EFO65514.1 - 0.19 12.0 8.1 0.43 10.9 0.1 3.7 3 0 0 3 3 3 0 TSC-22/dip/bun family Spc7 PF08317.11 EFO65514.1 - 0.4 9.5 27.4 1.2 7.9 7.4 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4795 PF16043.5 EFO65514.1 - 0.76 9.3 19.7 1.5 8.3 19.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) PspA_IM30 PF04012.12 EFO65514.1 - 0.97 9.0 25.5 0.6 9.6 16.6 2.4 1 1 1 2 2 2 0 PspA/IM30 family RmuC PF02646.16 EFO65514.1 - 1.1 8.4 18.5 1 8.5 0.2 3.5 2 2 1 3 3 3 0 RmuC family Fez1 PF06818.15 EFO65514.1 - 2.8 8.4 21.4 14 6.1 0.1 2.3 1 1 1 2 2 2 0 Fez1 DUF1759 PF03564.15 EFO65514.1 - 2.8 7.9 8.2 0.54 10.2 2.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) AAA_13 PF13166.6 EFO65514.1 - 2.9 6.4 23.0 0.55 8.8 18.1 1.9 1 1 1 2 2 2 0 AAA domain Sec34 PF04136.15 EFO65514.1 - 3.4 7.5 13.4 11 5.9 0.9 3.5 2 1 1 3 3 3 0 Sec34-like family DUF848 PF05852.11 EFO65514.1 - 3.8 7.6 21.2 0.32 11.1 3.6 3.3 3 0 0 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) HAUS5 PF14817.6 EFO65514.1 - 4.6 5.9 20.3 0.21 10.3 4.0 3.1 2 1 1 3 3 3 0 HAUS augmin-like complex subunit 5 Pox_F11 PF04943.12 EFO65514.1 - 7.2 5.6 7.9 12 4.9 7.9 1.3 1 0 0 1 1 1 0 Poxvirus F11 protein EzrA PF06160.12 EFO65515.1 - 0.0023 16.2 6.4 0.0032 15.7 6.4 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF16 PF01519.16 EFO65515.1 - 0.012 16.1 6.5 0.013 16.0 2.3 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF16 NPV_P10 PF05531.12 EFO65515.1 - 0.014 15.8 11.3 0.17 12.4 0.5 2.8 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4407 PF14362.6 EFO65515.1 - 0.041 13.2 3.2 0.068 12.5 3.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Kri1 PF05178.12 EFO65515.1 - 0.042 14.4 5.7 2.5 8.7 3.9 2.3 2 0 0 2 2 2 0 KRI1-like family Mit_KHE1 PF10173.9 EFO65515.1 - 0.08 13.0 1.0 0.14 12.2 1.0 1.3 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related DUF1664 PF07889.12 EFO65515.1 - 0.087 12.9 7.2 0.074 13.1 2.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Matrilin_ccoil PF10393.9 EFO65515.1 - 0.09 12.6 6.9 5.4 6.9 0.5 3.9 4 0 0 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin PSI_PsaF PF02507.15 EFO65515.1 - 0.1 12.4 0.1 0.18 11.6 0.1 1.4 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III Glyco_hydro_30C PF17189.4 EFO65515.1 - 0.12 12.6 0.2 1.7 8.9 0.0 2.4 2 0 0 2 2 2 0 Glycosyl hydrolase family 30 beta sandwich domain DUF4665 PF15679.5 EFO65515.1 - 0.18 12.5 2.3 0.24 12.0 0.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4665) HSBP1 PF06825.12 EFO65515.1 - 0.21 11.5 6.6 10 6.1 0.1 3.7 4 0 0 4 4 4 0 Heat shock factor binding protein 1 Exonuc_VII_L PF02601.15 EFO65515.1 - 0.5 9.9 5.1 0.8 9.2 5.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Hemagglutinin PF00509.18 EFO65515.1 - 0.73 8.2 3.3 1.1 7.5 3.3 1.2 1 0 0 1 1 1 0 Haemagglutinin MerR-DNA-bind PF09278.11 EFO65515.1 - 0.83 10.2 4.8 31 5.2 0.1 3.3 2 1 1 3 3 3 0 MerR, DNA binding DUF948 PF06103.11 EFO65515.1 - 1.4 9.3 5.6 0.47 10.7 1.1 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.10 EFO65515.1 - 1.7 8.8 12.8 0.8 9.9 4.8 2.4 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family UPF0242 PF06785.11 EFO65515.1 - 2 8.5 10.7 6.5 6.8 10.0 1.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Spectrin PF00435.21 EFO65515.1 - 2.4 8.7 8.3 2.9 8.4 3.5 2.4 2 0 0 2 2 2 0 Spectrin repeat CENP-F_leu_zip PF10473.9 EFO65515.1 - 4.5 7.3 16.0 0.4 10.7 8.3 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ABC_tran_CTD PF16326.5 EFO65515.1 - 5.6 7.3 12.5 26 5.1 6.7 2.7 2 0 0 2 2 2 0 ABC transporter C-terminal domain Peptidase_C1 PF00112.23 EFO65517.1 - 1.4e-16 61.2 0.1 4.1e-14 53.2 0.1 2.2 1 1 0 1 1 1 1 Papain family cysteine protease CathepsinC_exc PF08773.11 EFO65517.1 - 1.1e-11 45.0 0.2 2e-11 44.2 0.2 1.4 1 0 0 1 1 1 1 Cathepsin C exclusion domain Baculo_11_kDa PF06143.11 EFO65517.1 - 0.51 10.0 2.2 1.1 8.8 2.2 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family Med18 PF09637.10 EFO65518.1 - 0.00047 20.1 0.0 0.0012 18.7 0.0 1.7 1 1 1 2 2 2 1 Med18 protein DNA_pol_B PF00136.21 EFO65519.1 - 6.8e-120 400.9 1.7 4e-95 319.2 0.5 2.6 2 1 0 2 2 2 2 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EFO65519.1 - 3.3e-49 167.8 0.0 7e-49 166.8 0.0 1.6 1 1 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EFO65519.1 - 1.3e-07 32.0 3.4 3.2e-07 30.7 3.4 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta PPTA PF01239.22 EFO65520.1 - 8.1e-18 63.5 11.3 1.2e-05 24.9 0.3 5.3 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat Copine PF07002.16 EFO65522.1 - 1.4e-47 162.0 0.0 1.8e-47 161.6 0.0 1.1 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 EFO65522.1 - 3.5e-09 37.1 0.1 5.3e-09 36.5 0.1 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 EFO65522.1 - 0.13 12.5 0.0 0.22 11.8 0.0 1.6 1 1 0 1 1 1 0 von Willebrand factor type A domain Ank_2 PF12796.7 EFO65524.1 - 1.5e-18 67.2 0.3 4.3e-10 40.0 0.2 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO65524.1 - 4e-13 49.6 0.1 0.0061 17.1 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO65524.1 - 5.9e-10 39.2 0.3 0.033 14.5 0.0 3.9 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65524.1 - 9.5e-09 34.8 0.6 0.079 13.6 0.0 4.3 5 0 0 5 5 3 2 Ankyrin repeat Ank PF00023.30 EFO65524.1 - 1.2e-07 31.9 0.5 0.3 11.6 0.0 4.4 4 0 0 4 4 4 1 Ankyrin repeat bZIP_1 PF00170.21 EFO65524.1 - 1.9e-05 24.7 4.6 4.3e-05 23.5 0.9 2.9 2 0 0 2 2 2 1 bZIP transcription factor DivIC PF04977.15 EFO65524.1 - 3.3e-05 23.6 0.8 0.00012 21.8 0.3 2.0 2 0 0 2 2 2 1 Septum formation initiator NRBF2 PF08961.10 EFO65524.1 - 3.6e-05 23.4 0.3 3.6e-05 23.4 0.3 2.1 2 0 0 2 2 2 1 Nuclear receptor-binding factor 2, autophagy regulator ZapB PF06005.12 EFO65524.1 - 0.00034 21.0 5.0 0.0017 18.8 5.0 2.1 1 1 0 1 1 1 1 Cell division protein ZapB HAP1_N PF04849.13 EFO65524.1 - 0.0013 18.0 0.7 0.0013 18.0 0.7 1.8 3 0 0 3 3 2 1 HAP1 N-terminal conserved region TSC22 PF01166.18 EFO65524.1 - 0.0015 18.8 2.7 0.0094 16.2 0.5 3.0 2 0 0 2 2 2 1 TSC-22/dip/bun family MAD PF05557.13 EFO65524.1 - 0.0037 15.7 0.2 0.0056 15.1 0.2 1.3 1 0 0 1 1 1 1 Mitotic checkpoint protein DUF1192 PF06698.11 EFO65524.1 - 0.0046 17.0 0.3 0.01 15.9 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1192) Shugoshin_N PF07558.11 EFO65524.1 - 0.0064 16.3 0.6 0.015 15.1 0.6 1.7 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region CtIP_N PF10482.9 EFO65524.1 - 0.014 15.4 1.4 0.032 14.3 0.2 2.2 2 0 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain HOOK PF05622.12 EFO65524.1 - 0.018 13.2 0.7 0.026 12.7 0.7 1.2 1 0 0 1 1 1 0 HOOK protein SKA2 PF16740.5 EFO65524.1 - 0.029 14.2 3.1 0.045 13.5 1.3 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 TMF_TATA_bd PF12325.8 EFO65524.1 - 0.03 14.5 3.8 0.075 13.3 3.8 1.7 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF2381 PF09544.10 EFO65524.1 - 0.04 13.4 0.3 0.06 12.9 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2381) bZIP_2 PF07716.15 EFO65524.1 - 0.043 13.9 2.4 0.043 13.9 2.4 2.4 2 0 0 2 2 2 0 Basic region leucine zipper YabA PF06156.13 EFO65524.1 - 0.044 14.4 3.2 0.17 12.5 2.9 2.1 1 1 1 2 2 2 0 Initiation control protein YabA CENP-H PF05837.12 EFO65524.1 - 0.054 13.9 1.9 0.18 12.2 1.9 1.9 1 0 0 1 1 1 0 Centromere protein H (CENP-H) PRKG1_interact PF15898.5 EFO65524.1 - 0.063 14.2 0.4 0.063 14.2 0.4 3.0 3 1 0 3 3 2 0 cGMP-dependent protein kinase interacting domain APG6_N PF17675.1 EFO65524.1 - 0.1 13.1 1.1 1.1 9.8 0.4 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region Cnn_1N PF07989.11 EFO65524.1 - 0.13 12.5 0.4 0.13 12.5 0.4 2.3 3 0 0 3 3 1 0 Centrosomin N-terminal motif 1 GAT PF03127.14 EFO65524.1 - 0.16 12.3 3.4 7.2 7.0 0.2 3.3 3 0 0 3 3 3 0 GAT domain ADIP PF11559.8 EFO65524.1 - 0.17 12.0 3.6 0.59 10.2 3.5 1.8 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding FAM76 PF16046.5 EFO65524.1 - 0.23 10.8 3.1 0.47 9.8 3.1 1.4 1 1 0 1 1 1 0 FAM76 protein HALZ PF02183.18 EFO65524.1 - 0.32 11.3 3.8 0.43 10.8 1.0 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper DivIVA PF05103.13 EFO65524.1 - 0.9 9.6 3.7 2.9 8.0 1.0 2.5 2 1 0 2 2 2 0 DivIVA protein Mod_r PF07200.13 EFO65524.1 - 1.1 9.4 5.0 0.34 11.0 1.2 2.1 3 0 0 3 3 2 0 Modifier of rudimentary (Mod(r)) protein CCDC85 PF10226.9 EFO65524.1 - 5.7 6.6 7.5 0.27 10.9 0.3 2.3 3 0 0 3 3 2 0 CCDC85 family VSP PF03302.13 EFO65527.1 - 1.9e-06 27.0 310.8 0.03 13.2 20.4 13.0 1 1 11 12 12 12 8 Giardia variant-specific surface protein Med14 PF08638.11 EFO65528.1 - 0.096 12.1 0.1 0.22 10.9 0.1 1.5 1 0 0 1 1 1 0 Mediator complex subunit MED14 Guanylate_cyc PF00211.20 EFO65528.1 - 0.11 12.1 0.0 0.48 10.0 0.0 2.1 2 0 0 2 2 2 0 Adenylate and Guanylate cyclase catalytic domain Peptidase_C48 PF02902.19 EFO65529.1 - 9.8e-05 22.3 2.5 0.00033 20.5 0.9 2.3 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain DUF1664 PF07889.12 EFO65530.1 - 0.00045 20.3 3.5 0.00045 20.3 3.5 2.4 1 1 2 3 3 3 1 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.9 EFO65530.1 - 0.0008 19.4 18.7 0.006 16.6 7.4 2.3 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.8 EFO65530.1 - 0.00093 18.6 18.6 0.058 12.7 8.2 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3450) APG6_N PF17675.1 EFO65530.1 - 0.0015 19.1 20.4 0.059 13.9 11.3 2.1 1 1 1 2 2 2 2 Apg6 coiled-coil region Laminin_II PF06009.12 EFO65530.1 - 0.0021 18.1 11.4 0.097 12.7 2.4 2.2 1 1 1 2 2 2 2 Laminin Domain II ADIP PF11559.8 EFO65530.1 - 0.0022 18.1 22.6 0.074 13.1 7.9 2.3 1 1 1 2 2 2 2 Afadin- and alpha -actinin-Binding TMF_DNA_bd PF12329.8 EFO65530.1 - 0.0038 17.2 16.9 0.57 10.2 3.6 3.1 2 1 1 3 3 3 2 TATA element modulatory factor 1 DNA binding Fez1 PF06818.15 EFO65530.1 - 0.0054 17.2 9.3 0.0054 17.2 9.3 1.9 1 1 0 1 1 1 1 Fez1 CALCOCO1 PF07888.11 EFO65530.1 - 0.011 14.7 19.4 0.015 14.2 19.4 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like HAP1_N PF04849.13 EFO65530.1 - 0.015 14.5 18.7 0.1 11.8 8.6 2.8 1 1 2 3 3 3 0 HAP1 N-terminal conserved region DivIC PF04977.15 EFO65530.1 - 0.018 14.8 21.8 1.5 8.6 3.4 3.7 1 1 2 3 3 3 0 Septum formation initiator DUF4407 PF14362.6 EFO65530.1 - 0.03 13.7 17.5 0.083 12.2 17.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF16 PF01519.16 EFO65530.1 - 0.052 14.0 18.1 0.49 10.9 5.5 2.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 SKA1 PF07160.12 EFO65530.1 - 0.076 12.9 14.1 0.25 11.2 14.1 1.7 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 ERM PF00769.19 EFO65530.1 - 0.084 12.7 21.6 0.24 11.2 6.9 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family LPP PF04728.13 EFO65530.1 - 0.1 13.0 9.5 2.7 8.4 2.3 3.7 1 1 1 3 3 3 0 Lipoprotein leucine-zipper FapA PF03961.13 EFO65530.1 - 0.19 10.3 16.9 0.053 12.1 6.4 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A Fib_alpha PF08702.10 EFO65530.1 - 0.2 11.8 14.8 0.026 14.7 7.3 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family TPR_MLP1_2 PF07926.12 EFO65530.1 - 0.21 11.7 19.9 0.46 10.5 11.9 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein AAA_24 PF13479.6 EFO65530.1 - 0.21 11.3 7.3 0.095 12.4 4.4 1.7 1 1 1 2 2 2 0 AAA domain DUF948 PF06103.11 EFO65530.1 - 0.25 11.6 5.3 0.37 11.1 0.8 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TMF_TATA_bd PF12325.8 EFO65530.1 - 0.28 11.4 19.4 0.81 9.9 4.2 2.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Lectin_N PF03954.14 EFO65530.1 - 0.29 10.9 5.9 0.25 11.1 0.5 2.3 1 1 0 2 2 2 0 Hepatic lectin, N-terminal domain Occludin_ELL PF07303.13 EFO65530.1 - 0.29 11.9 14.5 0.046 14.4 5.5 2.5 1 1 1 2 2 2 0 Occludin homology domain YabA PF06156.13 EFO65530.1 - 0.33 11.6 15.4 10 6.8 3.5 2.9 1 1 1 2 2 2 0 Initiation control protein YabA ZapB PF06005.12 EFO65530.1 - 0.44 11.0 21.4 2.2 8.8 5.3 3.2 1 1 1 3 3 3 0 Cell division protein ZapB MqsA_antitoxin PF15731.5 EFO65530.1 - 0.48 10.5 3.8 0.3 11.2 0.8 1.9 1 1 1 2 2 2 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA WXG100 PF06013.12 EFO65530.1 - 0.5 10.6 7.9 0.86 9.9 1.3 3.2 2 1 0 3 3 3 0 Proteins of 100 residues with WXG FUSC PF04632.12 EFO65530.1 - 0.58 8.6 3.0 3 6.3 0.6 1.9 1 1 1 2 2 2 0 Fusaric acid resistance protein family ECH_2 PF16113.5 EFO65530.1 - 0.67 9.4 6.2 0.81 9.1 6.2 1.1 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase DUF4200 PF13863.6 EFO65530.1 - 0.82 10.1 24.8 0.32 11.4 4.3 3.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4200) DUF4094 PF13334.6 EFO65530.1 - 0.83 10.1 11.2 0.3 11.5 0.7 3.1 2 2 1 3 3 3 0 Domain of unknown function (DUF4094) BRE1 PF08647.11 EFO65530.1 - 1.1 9.4 19.6 2.5 8.2 8.7 2.5 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase ATG16 PF08614.11 EFO65530.1 - 1.4 9.1 22.3 2.9 8.1 10.2 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) YscO PF07321.12 EFO65530.1 - 1.9 8.4 18.2 4.7 7.2 17.0 2.0 1 1 0 1 1 1 0 Type III secretion protein YscO KELK PF15796.5 EFO65530.1 - 2 8.9 20.5 1.4 9.5 6.9 2.9 1 1 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase PspB PF06667.12 EFO65530.1 - 2.2 8.4 4.7 1.1 9.3 0.6 2.4 2 2 0 2 2 2 0 Phage shock protein B CENP-H PF05837.12 EFO65530.1 - 2.2 8.7 16.6 6.6 7.2 1.3 2.5 1 1 2 3 3 3 0 Centromere protein H (CENP-H) DUF4239 PF14023.6 EFO65530.1 - 2.5 7.8 6.3 3 7.5 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) FliD_N PF02465.18 EFO65530.1 - 2.6 8.8 7.7 33 5.2 7.7 2.6 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus UPF0242 PF06785.11 EFO65530.1 - 2.8 8.0 21.4 0.35 11.0 5.2 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF2203 PF09969.9 EFO65530.1 - 2.8 8.7 14.6 0.67 10.7 3.1 2.7 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) TSKS PF15358.6 EFO65530.1 - 3 6.1 10.2 0.23 9.8 3.6 1.9 1 1 1 2 2 2 0 Testis-specific serine kinase substrate XhlA PF10779.9 EFO65530.1 - 3.3 8.0 13.0 20 5.5 1.3 3.6 1 1 2 4 4 3 0 Haemolysin XhlA Atg14 PF10186.9 EFO65530.1 - 4.4 6.3 18.2 62 2.5 18.2 2.0 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 bZIP_1 PF00170.21 EFO65530.1 - 4.4 7.5 12.7 0.67 10.1 3.4 3.1 1 1 1 3 3 3 0 bZIP transcription factor I_LWEQ PF01608.17 EFO65530.1 - 5.2 7.3 13.8 0.31 11.3 6.1 2.0 1 1 1 2 2 2 0 I/LWEQ domain HemX PF04375.14 EFO65530.1 - 5.6 6.2 14.9 1e+02 2.0 14.9 2.0 1 1 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Phage_GP20 PF06810.11 EFO65530.1 - 5.7 6.7 18.3 2.7 7.8 5.5 2.3 1 1 1 2 2 2 0 Phage minor structural protein GP20 OmpH PF03938.14 EFO65530.1 - 5.9 7.2 21.2 13 6.1 6.8 2.6 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Csm1_N PF18504.1 EFO65530.1 - 6.9 7.1 20.3 1.8 8.9 3.6 3.5 1 1 0 3 3 3 0 Csm1 N-terminal domain Fe-S_biosyn PF01521.20 EFO65532.1 - 1.1e-12 48.1 0.0 1.3e-12 47.9 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis PS_Dcarbxylase PF02666.15 EFO65534.1 - 1.7e-39 135.4 0.0 2.7e-39 134.8 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Ank_2 PF12796.7 EFO65536.1 - 5.8e-85 280.0 21.5 3.9e-13 49.8 0.1 8.7 3 2 5 8 8 8 8 Ankyrin repeats (3 copies) Ank PF00023.30 EFO65536.1 - 1.7e-45 151.6 23.4 0.0033 17.8 0.0 16.3 15 1 1 16 16 16 11 Ankyrin repeat Ank_4 PF13637.6 EFO65536.1 - 1.8e-45 152.8 20.1 6.6e-06 26.6 0.0 13.2 8 4 5 13 13 13 12 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO65536.1 - 3.4e-45 151.5 22.6 1.2e-07 31.9 0.0 13.8 4 2 10 14 14 14 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65536.1 - 8.9e-40 130.2 21.6 0.0099 16.3 0.0 16.5 15 1 1 16 16 16 13 Ankyrin repeat Pkinase PF00069.25 EFO65536.1 - 4.3e-05 23.0 0.2 0.00037 20.0 0.2 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65536.1 - 0.0016 17.8 0.0 0.0035 16.7 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Abhydrolase_6 PF12697.7 EFO65537.1 - 4e-15 57.0 0.0 4.8e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFO65537.1 - 5e-15 55.8 0.0 3.9e-14 52.9 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFO65537.1 - 1.1e-12 47.8 0.0 2.4e-12 46.7 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EFO65537.1 - 0.00024 21.3 0.0 0.00037 20.7 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain LIDHydrolase PF10230.9 EFO65537.1 - 0.001 18.7 0.0 0.0015 18.2 0.0 1.4 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Chlorophyllase2 PF12740.7 EFO65537.1 - 0.0016 17.4 0.0 0.0025 16.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.21 EFO65537.1 - 0.0084 15.6 0.0 0.017 14.6 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family PGAP1 PF07819.13 EFO65537.1 - 0.012 15.3 0.0 0.029 14.1 0.0 1.6 2 0 0 2 2 2 0 PGAP1-like protein DUF900 PF05990.12 EFO65537.1 - 0.039 13.4 0.2 3.1 7.3 0.3 2.8 2 1 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) LCAT PF02450.15 EFO65537.1 - 0.045 12.9 0.0 0.15 11.2 0.0 1.7 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase Palm_thioest PF02089.15 EFO65537.1 - 0.05 13.4 0.0 0.065 13.1 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Chlorophyllase PF07224.11 EFO65537.1 - 0.082 11.9 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase LSM PF01423.22 EFO65538.1 - 8.7e-09 35.0 0.0 1.2e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 LSM domain RHS_repeat PF05593.14 EFO65538.1 - 0.14 12.7 0.5 0.24 12.0 0.5 1.5 1 0 0 1 1 1 0 RHS Repeat Rubredoxin PF00301.20 EFO65538.1 - 0.15 12.1 0.2 0.39 10.8 0.0 1.7 2 0 0 2 2 2 0 Rubredoxin Spec3 PF15795.5 EFO65541.1 - 8.1e-07 29.5 17.7 1.7e-05 25.3 17.7 2.1 1 1 0 1 1 1 1 Ectodermal ciliogenesis protein bacHORMA_1 PF18138.1 EFO65543.1 - 0.016 15.1 2.4 0.11 12.4 0.1 2.7 2 0 0 2 2 2 0 Bacterial HORMA domain family 1 ELF PF03317.13 EFO65544.1 - 0.022 14.7 0.0 0.48 10.4 0.0 2.7 2 0 0 2 2 2 0 ELF protein AF-4 PF05110.13 EFO65544.1 - 0.29 9.2 6.1 0.52 8.3 6.1 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Sigma70_ner PF04546.13 EFO65544.1 - 3.7 7.4 9.5 0.18 11.6 1.8 2.7 3 0 0 3 3 3 0 Sigma-70, non-essential region Glycos_transf_2 PF00535.26 EFO65545.1 - 5.9e-17 62.0 0.0 1e-16 61.2 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EFO65545.1 - 3.6e-05 23.8 0.0 4.1e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EFO65545.1 - 0.1 12.0 0.0 0.42 10.1 0.0 1.9 1 1 1 2 2 2 0 Glycosyl transferase family 21 zf-B_box PF00643.24 EFO65547.1 - 4.6e-08 33.1 14.1 1.1e-05 25.5 1.4 3.7 4 0 0 4 4 4 2 B-box zinc finger TolA_bind_tri PF16331.5 EFO65547.1 - 0.016 15.3 0.8 0.037 14.1 0.8 1.6 1 0 0 1 1 1 0 TolA binding protein trimerisation zinc_ribbon_15 PF17032.5 EFO65547.1 - 0.039 14.7 11.4 0.12 13.1 0.7 3.4 3 0 0 3 3 3 0 zinc-ribbon family Cript PF10235.9 EFO65547.1 - 0.42 11.2 14.1 1.8 9.2 2.7 3.3 2 1 1 3 3 3 0 Microtubule-associated protein CRIPT DUF4106 PF13388.6 EFO65547.1 - 0.63 9.2 3.1 0.71 9.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4106) DUF3450 PF11932.8 EFO65548.1 - 0.041 13.2 1.3 0.057 12.7 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) CCDC144C PF14915.6 EFO65548.1 - 0.046 12.8 3.8 0.061 12.4 3.8 1.1 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region DUF4423 PF14394.6 EFO65548.1 - 0.074 12.8 1.4 8.3 6.1 1.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4423) DUF2203 PF09969.9 EFO65548.1 - 0.094 13.4 1.1 0.15 12.8 1.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) TMPIT PF07851.13 EFO65548.1 - 0.42 9.8 1.9 0.56 9.4 1.9 1.1 1 0 0 1 1 1 0 TMPIT-like protein Glyco_tranf_2_3 PF13641.6 EFO65549.1 - 2.8e-09 37.2 0.0 6.8e-09 35.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EFO65549.1 - 8e-06 25.9 1.4 8e-06 25.9 1.4 2.3 2 0 0 2 2 2 1 Glycosyl transferase family group 2 TctA PF01970.16 EFO65549.1 - 5.2 5.7 10.9 0.14 10.9 2.4 2.1 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctA family Desulfoferrodox PF01880.18 EFO65550.1 - 2.8e-14 53.5 0.0 3.7e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Desulfoferrodoxin SSURE PF11966.8 EFO65550.1 - 0.091 12.5 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Fibronectin-binding repeat Ank_2 PF12796.7 EFO65551.1 - 1.1e-73 243.8 25.9 1.5e-13 51.1 0.1 8.9 1 1 9 10 10 10 10 Ankyrin repeats (3 copies) Ank PF00023.30 EFO65551.1 - 7.7e-43 143.1 26.0 0.00092 19.6 0.0 14.7 14 1 1 15 15 15 10 Ankyrin repeat Ank_4 PF13637.6 EFO65551.1 - 1.2e-41 140.5 19.3 4.7e-09 36.6 0.0 12.4 7 4 7 14 14 14 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO65551.1 - 3.2e-41 138.8 23.6 1.1e-06 28.8 0.0 12.3 3 3 9 13 13 13 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65551.1 - 1.1e-28 96.1 20.7 0.026 15.0 0.0 14.2 13 1 1 14 14 14 9 Ankyrin repeat Ank_2 PF12796.7 EFO65552.1 - 8.4e-09 35.9 4.1 1.1e-05 25.9 0.1 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO65552.1 - 6.1e-06 26.4 0.0 0.00011 22.4 0.0 2.7 1 1 2 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO65552.1 - 0.00015 22.3 1.8 0.028 15.0 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65552.1 - 0.012 16.1 0.4 0.87 10.3 0.0 3.6 4 0 0 4 4 4 0 Ankyrin repeat DivIC PF04977.15 EFO65552.1 - 0.057 13.2 0.1 0.057 13.2 0.1 3.5 4 0 0 4 4 4 0 Septum formation initiator Csm1_N PF18504.1 EFO65552.1 - 0.15 12.5 0.3 0.15 12.5 0.3 4.0 4 1 0 4 4 4 0 Csm1 N-terminal domain ZapB PF06005.12 EFO65552.1 - 0.18 12.3 18.6 3.9 8.0 5.4 4.2 4 1 0 4 4 4 0 Cell division protein ZapB LPP PF04728.13 EFO65552.1 - 0.23 11.9 0.1 0.23 11.9 0.1 3.5 3 1 1 4 4 4 0 Lipoprotein leucine-zipper LRRFIP PF09738.9 EFO65552.1 - 1.5 8.2 16.9 0.5 9.8 13.7 1.9 1 1 0 1 1 1 0 LRRFIP family Cep57_CLD_2 PF14197.6 EFO65552.1 - 3.2 7.9 9.2 2.9 8.1 0.1 3.9 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 CENP-H PF05837.12 EFO65552.1 - 4.8 7.6 19.9 0.45 10.9 6.8 3.2 3 1 0 3 3 3 0 Centromere protein H (CENP-H) Ank_2 PF12796.7 EFO65553.1 - 1.1e-20 73.9 1.7 9e-09 35.8 0.0 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO65553.1 - 9e-08 32.5 0.1 0.031 14.9 0.0 4.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65553.1 - 1.3e-06 28.2 0.1 5.8 7.8 0.0 5.2 5 0 0 5 5 5 1 Ankyrin repeat Ank PF00023.30 EFO65553.1 - 3.1e-06 27.4 0.1 11 6.6 0.0 4.8 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 EFO65553.1 - 0.0023 18.2 0.0 2.7 8.4 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Trimer_CC PF08954.11 EFO65553.1 - 0.03 13.9 0.5 1.7 8.2 0.2 2.9 2 0 0 2 2 2 0 Trimerisation motif DUF812 PF05667.11 EFO65553.1 - 0.031 13.2 20.2 0.0031 16.5 15.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF812) DivIC PF04977.15 EFO65553.1 - 0.037 13.8 0.1 0.037 13.8 0.1 5.5 5 2 0 6 6 6 0 Septum formation initiator Peptidase_C101 PF16218.5 EFO65553.1 - 0.6 9.3 5.6 0.81 8.9 3.3 1.9 1 1 1 2 2 2 0 Peptidase family C101 Mga PF05043.13 EFO65553.1 - 1.5 9.5 3.8 1.7 9.2 0.3 2.8 3 0 0 3 3 3 0 Mga helix-turn-helix domain DUF3461 PF11944.8 EFO65553.1 - 1.9 8.6 8.6 2.1 8.5 2.3 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3461) Fib_alpha PF08702.10 EFO65553.1 - 2.5 8.3 19.6 0.1 12.8 6.0 3.9 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family Fez1 PF06818.15 EFO65553.1 - 3.6 8.0 27.3 22 5.4 1.2 3.6 2 1 1 3 3 3 0 Fez1 Lebercilin PF15619.6 EFO65553.1 - 5.2 6.7 29.6 0.13 11.9 13.7 3.4 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF1664 PF07889.12 EFO65553.1 - 8 6.5 8.9 41 4.2 6.5 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DELLA PF12041.8 EFO65555.1 - 0.11 12.4 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator DELLA protein N terminal DHHC PF01529.20 EFO65556.1 - 1.2e-27 96.7 12.1 1.2e-27 96.7 12.1 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase PI3K_1B_p101 PF10486.9 EFO65556.1 - 0.69 7.6 13.6 0.94 7.2 13.6 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CDC45 PF02724.14 EFO65556.1 - 1.3 7.3 9.8 1.8 6.7 9.8 1.2 1 0 0 1 1 1 0 CDC45-like protein TBD PF12845.7 EFO65557.1 - 0.028 14.3 0.3 3.7 7.5 0.0 3.4 3 0 0 3 3 3 0 TBD domain DUF2092 PF09865.9 EFO65557.1 - 0.051 12.9 0.3 0.087 12.2 0.3 1.3 1 0 0 1 1 1 0 Predicted periplasmic protein (DUF2092) tRNA-synt_1 PF00133.22 EFO65558.1 - 7.5e-40 136.8 0.3 2.2e-21 75.8 0.0 4.3 3 1 0 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EFO65558.1 - 8.4e-19 67.6 1.7 1.6e-09 37.1 0.0 3.8 4 0 0 4 4 4 2 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EFO65558.1 - 3.8e-07 29.8 0.0 6.6e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 EFO65558.1 - 3.3e-05 23.9 0.0 7.9e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA RNA_pol_Rpb1_5 PF04998.17 EFO65559.1 - 3.3e-57 193.9 0.0 9.5e-57 192.4 0.0 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EFO65559.1 - 6.1e-56 189.2 0.0 1.5e-55 187.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EFO65559.1 - 2.7e-34 118.4 0.0 8.7e-34 116.7 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 EFO65559.1 - 6.5e-18 65.1 4.9 8.4e-18 64.7 0.6 2.9 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 EFO65559.1 - 6.5e-15 55.0 0.1 2e-14 53.5 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_6 PF04992.14 EFO65559.1 - 8.7e-12 45.3 0.2 2.9e-11 43.5 0.2 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.12 EFO65559.1 - 0.025 14.6 0.3 0.063 13.3 0.3 1.7 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 7 DUF4611 PF15387.6 EFO65559.1 - 1.5 9.1 3.7 0.45 10.8 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) MCC-bdg_PDZ PF10506.9 EFO65560.1 - 0.032 14.2 0.9 0.032 14.2 0.9 4.8 3 1 1 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome MPS2 PF17060.5 EFO65560.1 - 0.6 9.3 12.7 0.084 12.1 1.5 2.7 2 1 0 2 2 2 0 Monopolar spindle protein 2 DLP_helical PF18709.1 EFO65560.1 - 2.1 7.5 17.2 0.15 11.2 2.3 3.1 2 1 1 3 3 3 0 Dynamin-like helical domain Bcr-Abl_Oligo PF09036.10 EFO65560.1 - 4.3 7.4 6.3 1.6 8.8 0.5 2.9 1 1 1 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain PhaP_Bmeg PF09602.10 EFO65560.1 - 5.6 6.9 16.1 0.3 11.0 0.6 3.2 4 0 0 4 4 4 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) BLOC1_2 PF10046.9 EFO65562.1 - 0.43 10.9 18.0 0.37 11.1 2.5 4.1 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spc7 PF08317.11 EFO65562.1 - 6.8 5.5 36.0 5.1 5.9 12.3 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein FlaC_arch PF05377.11 EFO65562.1 - 7.8 7.0 12.3 5.9 7.4 0.1 4.5 3 1 0 5 5 5 0 Flagella accessory protein C (FlaC) SRP40_C PF05022.12 EFO65563.1 - 0.00034 21.4 0.1 0.00068 20.4 0.1 1.5 1 0 0 1 1 1 1 SRP40, C-terminal domain tRNA-synt_1g PF09334.11 EFO65564.1 - 1.6e-86 290.5 0.0 7.3e-86 288.4 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EFO65564.1 - 1.2e-18 66.7 0.9 1.6e-10 39.9 0.5 3.3 1 1 2 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EFO65564.1 - 9.3e-08 31.8 0.0 0.0019 17.6 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 EFO65564.1 - 0.022 14.7 0.0 0.054 13.5 0.0 1.6 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA DNA_primase_S PF01896.19 EFO65565.1 - 3.8e-33 115.0 0.0 7.3e-33 114.1 0.0 1.4 1 0 0 1 1 1 1 DNA primase small subunit LRR_RI_capping PF18779.1 EFO65565.1 - 0.014 15.1 0.1 0.03 14.0 0.1 1.5 1 0 0 1 1 1 0 Capping Ribonuclease inhibitor Leucine Rich Repeat VSP PF03302.13 EFO65566.1 - 1.4e-87 294.1 103.1 1.2e-48 166.0 23.1 4.0 1 1 3 4 4 4 4 Giardia variant-specific surface protein VSP PF03302.13 EFO65567.1 - 7.3e-47 160.1 185.7 1.8e-32 112.7 74.3 7.4 1 1 5 6 6 6 6 Giardia variant-specific surface protein LCIB_C_CA PF18599.1 EFO65568.1 - 0.44 9.8 2.4 0.41 9.9 0.2 2.0 2 0 0 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases Annexin PF00191.20 EFO65569.1 - 3.5e-15 55.8 3.1 5e-05 23.3 0.2 4.3 4 0 0 4 4 4 3 Annexin DUF807 PF05660.11 EFO65569.1 - 0.057 13.4 0.0 0.098 12.6 0.0 1.3 1 0 0 1 1 1 0 Coxiella burnetii protein of unknown function (DUF807) ATP_synt_H PF05493.13 EFO65571.1 - 1.3e-15 57.6 2.4 1.6e-15 57.3 2.4 1.1 1 0 0 1 1 1 1 ATP synthase subunit H DUF4131 PF13567.6 EFO65571.1 - 0.035 13.8 1.1 0.039 13.6 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) SLATT_fungal PF18142.1 EFO65571.1 - 0.11 12.5 0.4 0.13 12.2 0.4 1.1 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain Smr PF01713.21 EFO65572.1 - 7e-07 29.5 0.0 1.6e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Smr domain Helicase_PWI PF18149.1 EFO65572.1 - 0.00084 19.5 0.0 0.0022 18.2 0.0 1.7 1 0 0 1 1 1 1 N-terminal helicase PWI domain TAP_C PF03943.13 EFO65572.1 - 0.038 13.6 0.6 0.076 12.7 0.1 1.8 1 1 1 2 2 2 0 TAP C-terminal domain Pkinase PF00069.25 EFO65573.1 - 1.9e-41 142.2 0.0 5.3e-41 140.7 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65573.1 - 3.9e-14 52.6 0.0 3.9e-13 49.3 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EFO65573.1 - 0.15 11.4 0.3 0.28 10.5 0.3 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WD40 PF00400.32 EFO65574.1 - 1.5e-10 41.5 11.8 2.6e-06 28.0 0.3 5.5 5 1 0 5 5 5 3 WD domain, G-beta repeat DUF1668 PF07893.13 EFO65574.1 - 0.0023 17.4 0.0 2.3 7.5 0.0 2.5 3 0 0 3 3 3 2 Protein of unknown function (DUF1668) ANAPC4_WD40 PF12894.7 EFO65574.1 - 0.0024 18.1 0.0 1.4 9.3 0.1 3.9 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_M49 PF03571.15 EFO65576.1 - 4.1e-145 484.3 0.0 5.3e-145 483.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M49 DUF3072 PF11272.8 EFO65577.1 - 0.016 15.1 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3072) TBCC PF07986.12 EFO65578.1 - 1.1e-11 44.5 10.4 2.3e-11 43.5 10.4 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 EFO65578.1 - 2.9e-05 23.7 0.6 4.7e-05 23.1 0.6 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TPH PF13868.6 EFO65579.1 - 1.3e-35 122.5 143.4 1.3e-35 122.5 143.4 2.0 1 1 1 2 2 2 1 Trichohyalin-plectin-homology domain DUF2760 PF10816.8 EFO65579.1 - 0.064 13.1 4.5 0.06 13.2 1.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF2760) Ank_2 PF12796.7 EFO65581.1 - 1.5e-61 204.9 16.5 1.5e-12 48.0 1.1 6.7 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO65581.1 - 5e-35 119.1 22.9 0.00024 21.3 0.1 11.1 2 2 10 12 12 12 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65581.1 - 2.6e-33 110.3 9.6 0.0083 16.6 0.0 10.9 11 0 0 11 11 11 9 Ankyrin repeat Ank_4 PF13637.6 EFO65581.1 - 1.7e-31 108.2 14.0 8.6e-06 26.2 0.4 9.2 6 3 4 10 10 10 8 Ankyrin repeats (many copies) Ank PF00023.30 EFO65581.1 - 9.7e-31 104.9 10.7 0.018 15.5 0.0 11.2 10 1 1 11 11 11 9 Ankyrin repeat Pkinase PF00069.25 EFO65581.1 - 7e-09 35.4 0.1 1.6e-08 34.3 0.1 1.6 1 0 0 1 1 1 1 Protein kinase domain DUF2634 PF10934.8 EFO65581.1 - 0.055 13.6 3.1 0.077 13.1 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2634) Bromodomain PF00439.25 EFO65583.1 - 5.5e-17 61.6 0.1 2e-16 59.8 0.0 1.9 2 0 0 2 2 2 1 Bromodomain CAML PF14963.6 EFO65583.1 - 0.0037 17.4 0.0 0.0056 16.8 0.0 1.2 1 0 0 1 1 1 1 Calcium signal-modulating cyclophilin ligand BET PF17035.5 EFO65583.1 - 0.014 15.5 0.0 0.048 13.8 0.0 1.9 2 0 0 2 2 2 0 Bromodomain extra-terminal - transcription regulation Memo PF01875.17 EFO65584.1 - 1.1e-46 159.2 0.0 1.5e-46 158.8 0.0 1.1 1 0 0 1 1 1 1 Memo-like protein Pkinase PF00069.25 EFO65585.1 - 2.4e-58 197.6 0.0 3e-58 197.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EFO65585.1 - 1.1e-41 141.2 7.8 2.6e-10 40.7 0.2 5.8 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EFO65585.1 - 9.5e-38 129.9 0.0 1.3e-37 129.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_5 PF13857.6 EFO65585.1 - 7.8e-25 86.6 7.8 3.6e-07 30.3 0.0 7.2 4 2 4 8 8 8 5 Ankyrin repeats (many copies) Ank PF00023.30 EFO65585.1 - 7.7e-23 79.9 10.4 0.077 13.5 0.1 9.8 9 1 1 10 10 10 5 Ankyrin repeat Ank_3 PF13606.6 EFO65585.1 - 1.4e-22 77.4 5.6 0.099 13.2 0.0 10.1 10 0 0 10 10 10 6 Ankyrin repeat Ank_4 PF13637.6 EFO65585.1 - 1.2e-20 73.6 8.0 2.5e-06 27.9 0.1 7.4 6 2 1 7 7 7 4 Ankyrin repeats (many copies) Kinase-like PF14531.6 EFO65585.1 - 1e-08 34.9 0.1 3.4e-07 29.9 0.0 2.9 2 1 1 3 3 3 2 Kinase-like APH PF01636.23 EFO65585.1 - 0.01 15.8 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFO65585.1 - 0.022 13.7 1.3 0.12 11.2 1.3 1.9 1 1 0 1 1 1 0 Haspin like kinase domain ATP-synt_E_2 PF08112.11 EFO65587.1 - 0.035 14.4 0.2 0.087 13.1 0.2 1.7 1 0 0 1 1 1 0 ATP synthase epsilon subunit DNA_mis_repair PF01119.19 EFO65588.1 - 6.8e-12 45.1 0.5 2.2e-11 43.4 0.0 2.0 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EFO65588.1 - 1.5e-06 28.1 0.1 4.3e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFO65588.1 - 0.012 16.1 0.0 0.036 14.6 0.0 1.8 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SMC_N PF02463.19 EFO65589.1 - 1.3e-19 70.5 0.0 5.6e-11 42.3 0.0 2.8 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFO65589.1 - 9.7e-12 45.8 55.7 5.4e-11 43.4 23.9 5.1 3 1 0 3 3 3 1 AAA domain AAA_15 PF13175.6 EFO65589.1 - 5.1e-11 42.9 15.3 1.6e-09 38.0 0.0 4.4 2 2 1 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 EFO65589.1 - 1.9e-05 24.3 0.0 4.6e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_27 PF13514.6 EFO65589.1 - 0.00014 21.5 0.0 0.00014 21.5 0.0 3.9 4 1 1 5 5 5 1 AAA domain AAA_21 PF13304.6 EFO65589.1 - 0.00028 20.8 1.7 0.0017 18.2 0.1 2.9 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system ADIP PF11559.8 EFO65589.1 - 0.0028 17.8 4.3 0.0028 17.8 4.3 7.2 4 2 3 7 7 7 1 Afadin- and alpha -actinin-Binding AAA_16 PF13191.6 EFO65589.1 - 0.072 13.5 0.0 0.072 13.5 0.0 3.5 3 1 0 3 3 3 0 AAA ATPase domain ABC_tran PF00005.27 EFO65589.1 - 0.092 13.3 0.0 0.092 13.3 0.0 5.0 4 3 0 5 5 5 0 ABC transporter DNA_ligase_A_M PF01068.21 EFO65590.1 - 1.8e-40 138.8 0.9 4.6e-40 137.4 0.9 1.7 1 1 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EFO65590.1 - 2.2e-27 96.5 0.1 5.1e-27 95.3 0.1 1.7 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EFO65590.1 - 1.2e-19 70.8 0.0 3.7e-19 69.2 0.0 1.9 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region GTP_EFTU PF00009.27 EFO65591.1 - 8.2e-05 22.2 0.0 0.00014 21.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFO65591.1 - 0.0032 17.6 0.0 0.0089 16.1 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Virul_Fac PF10139.9 EFO65591.1 - 0.023 12.9 0.1 0.033 12.4 0.1 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor SRPRB PF09439.10 EFO65591.1 - 0.025 14.0 0.1 0.082 12.3 0.1 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 EFO65591.1 - 0.067 13.7 0.1 0.19 12.3 0.1 1.7 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 EFO65591.1 - 0.099 13.1 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFO65591.1 - 0.13 12.8 0.0 0.3 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_13 PF13166.6 EFO65591.1 - 0.18 10.4 0.1 0.27 9.8 0.1 1.2 1 0 0 1 1 1 0 AAA domain IF-2B PF01008.17 EFO65592.1 - 5.8e-24 84.8 0.0 1.7e-23 83.3 0.0 1.6 1 1 0 1 1 1 1 Initiation factor 2 subunit family Ank_2 PF12796.7 EFO65593.1 - 7.3e-27 93.8 12.7 3.1e-12 46.9 0.5 3.5 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO65593.1 - 5e-23 81.8 0.0 1.1e-22 80.7 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65593.1 - 1.4e-13 50.8 0.0 2.5e-12 46.6 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Ank_5 PF13857.6 EFO65593.1 - 1.9e-08 34.4 3.3 1.7e-05 25.0 0.1 4.2 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EFO65593.1 - 2.6e-08 33.9 0.6 0.1 13.1 0.0 4.8 4 1 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EFO65593.1 - 2.6e-07 31.0 0.6 0.0088 16.6 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65593.1 - 5.5e-07 29.4 1.3 2.2 9.1 0.0 5.5 5 0 0 5 5 5 2 Ankyrin repeat TBCC PF07986.12 EFO65595.1 - 1.3e-28 99.1 4.0 2.2e-28 98.4 4.0 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 EFO65595.1 - 0.004 16.8 0.2 0.0065 16.1 0.2 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal SRP19 PF01922.17 EFO65597.1 - 2.3e-10 41.3 0.0 2.9e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 SRP19 protein Yae1_N PF09811.9 EFO65597.1 - 0.1 12.3 0.0 8.7 6.1 0.0 2.3 2 0 0 2 2 2 0 Essential protein Yae1, N terminal bZIP_2 PF07716.15 EFO65598.1 - 3e-10 40.0 8.8 4.4e-10 39.5 8.8 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EFO65598.1 - 2.5e-06 27.5 5.1 4.6e-06 26.6 5.1 1.3 1 0 0 1 1 1 1 bZIP transcription factor IATP PF04568.12 EFO65598.1 - 1 9.8 4.1 2.2 8.8 4.1 1.5 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP RVT_1 PF00078.27 EFO65599.1 - 2.9e-14 53.1 0.0 4.1e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_9 PF16293.5 EFO65599.1 - 0.041 13.7 0.1 0.071 13.0 0.1 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) VSP PF03302.13 EFO65600.1 - 1.1e-25 90.3 98.9 2e-18 66.4 40.6 4.0 1 1 2 3 3 3 3 Giardia variant-specific surface protein Ank_2 PF12796.7 EFO65601.1 - 5.5e-18 65.3 0.4 3.7e-07 30.6 0.0 4.3 1 1 2 4 4 4 3 Ankyrin repeats (3 copies) zf-C3HC4_3 PF13920.6 EFO65601.1 - 1.9e-10 40.4 19.0 1.2e-09 37.9 15.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Ank_3 PF13606.6 EFO65601.1 - 3.9e-10 39.1 4.6 0.18 12.4 0.0 7.0 6 1 1 7 7 7 2 Ankyrin repeat Ank PF00023.30 EFO65601.1 - 3.8e-09 36.6 5.2 0.19 12.2 0.0 6.5 5 1 1 6 6 6 2 Ankyrin repeat Ank_4 PF13637.6 EFO65601.1 - 9.9e-08 32.4 1.8 0.22 12.1 0.0 5.7 4 1 2 6 6 6 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO65601.1 - 1.5e-05 25.2 3.2 1.4 9.4 0.0 5.4 4 2 1 5 5 5 1 Ankyrin repeats (many copies) zf-C3HC4 PF00097.25 EFO65601.1 - 0.00013 21.7 19.3 0.001 18.9 18.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFO65601.1 - 0.0014 18.9 17.8 0.0014 18.9 17.8 2.2 2 0 0 2 2 2 1 Ring finger domain DUF1815 PF08844.10 EFO65601.1 - 0.062 13.3 1.4 9.8 6.2 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1815) Prok-RING_4 PF14447.6 EFO65601.1 - 1.3 8.9 19.9 0.11 12.4 15.0 1.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Ribosomal_S7 PF00177.21 EFO65602.1 - 2.3e-34 118.2 0.4 2.9e-34 117.8 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Ank_2 PF12796.7 EFO65604.1 - 2.7e-41 140.0 11.0 4.2e-14 52.9 0.0 4.8 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO65604.1 - 2.8e-24 84.9 11.2 4.9e-05 23.5 0.0 8.7 5 2 4 9 9 9 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO65604.1 - 4.7e-22 78.0 7.4 5.5e-07 30.0 0.3 6.5 5 2 2 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO65604.1 - 1.2e-20 73.0 8.8 0.0042 17.5 0.0 7.7 7 1 1 8 8 8 6 Ankyrin repeat Ank_3 PF13606.6 EFO65604.1 - 1.1e-16 59.2 9.2 0.022 15.3 0.0 9.0 9 0 0 9 9 9 4 Ankyrin repeat FUSC PF04632.12 EFO65606.1 - 0.29 9.6 0.2 0.46 9.0 0.2 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family TBPIP PF07106.13 EFO65608.1 - 4.5e-23 81.0 0.6 1.1e-22 79.8 0.6 1.7 1 0 0 1 1 1 1 TBPIP/Hop2 winged helix domain LZ3wCH PF18517.1 EFO65608.1 - 4.4e-05 23.5 0.0 0.00016 21.7 0.0 2.0 2 0 0 2 2 2 1 Leucine zipper with capping helix domain Creatinase_N PF01321.18 EFO65608.1 - 0.011 16.3 0.1 3.4 8.3 0.0 2.5 2 1 0 2 2 2 0 Creatinase/Prolidase N-terminal domain Transcrip_act PF04949.13 EFO65608.1 - 0.018 14.9 1.0 0.033 14.1 0.1 1.9 2 0 0 2 2 2 0 Transcriptional activator Helicase_C_3 PF13625.6 EFO65608.1 - 0.043 14.0 0.1 0.36 11.0 0.0 2.2 2 1 0 2 2 2 0 Helicase conserved C-terminal domain Syntaxin_2 PF14523.6 EFO65608.1 - 0.093 13.1 4.7 0.074 13.4 1.8 2.1 2 0 0 2 2 2 0 Syntaxin-like protein FAM76 PF16046.5 EFO65608.1 - 0.32 10.3 2.9 0.44 9.9 2.9 1.3 1 0 0 1 1 1 0 FAM76 protein DUF16 PF01519.16 EFO65608.1 - 1.1 9.7 5.7 9.8 6.7 5.5 2.4 1 1 0 1 1 1 0 Protein of unknown function DUF16 FliT PF05400.13 EFO65608.1 - 2 9.3 8.5 1.1 10.1 2.8 3.0 3 0 0 3 3 3 0 Flagellar protein FliT FlxA PF14282.6 EFO65608.1 - 2.6 8.1 12.1 0.19 11.7 6.7 1.9 2 0 0 2 2 2 0 FlxA-like protein YabA PF06156.13 EFO65608.1 - 2.7 8.7 6.2 3.2 8.4 3.9 2.3 1 1 1 2 2 2 0 Initiation control protein YabA TolA_bind_tri PF16331.5 EFO65608.1 - 6.4 6.9 12.0 7.9 6.6 3.1 2.5 1 1 1 2 2 2 0 TolA binding protein trimerisation Uso1_p115_C PF04871.13 EFO65608.1 - 9.9 6.5 9.0 0.46 10.9 2.6 2.0 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Gp_dh_C PF02800.20 EFO65609.1 - 6.4e-60 201.3 0.0 9.3e-60 200.8 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EFO65609.1 - 2.7e-20 72.6 0.0 4.2e-19 68.8 0.0 2.4 1 1 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Transketolase_N PF00456.21 EFO65610.1 - 0.088 11.7 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Transketolase, thiamine diphosphate binding domain FHA PF00498.26 EFO65612.1 - 9.2e-17 61.2 0.1 1.7e-16 60.3 0.1 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EFO65612.1 - 2.7e-09 37.2 0.0 6e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Pheromone PF08015.11 EFO65612.1 - 0.021 15.9 0.4 0.021 15.9 0.4 2.7 3 0 0 3 3 3 0 Fungal mating-type pheromone T2SSF PF00482.23 EFO65612.1 - 0.12 12.3 0.5 5.9 6.9 0.0 2.4 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F Cyt-b5 PF00173.28 EFO65615.1 - 3.8e-15 55.8 0.0 7.7e-15 54.8 0.0 1.5 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Phage_GP20 PF06810.11 EFO65616.1 - 0.0078 16.0 6.2 0.61 9.9 1.1 2.4 2 0 0 2 2 2 2 Phage minor structural protein GP20 Ald_deCOase PF11266.8 EFO65616.1 - 0.0094 15.7 0.6 0.052 13.3 0.0 2.0 2 0 0 2 2 2 1 Long-chain fatty aldehyde decarbonylase DUF4242 PF14026.6 EFO65616.1 - 0.038 14.2 0.6 0.43 10.8 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4242) DUF5344 PF17279.2 EFO65616.1 - 0.13 12.9 3.8 0.33 11.5 3.8 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5344) PTB PF08416.13 EFO65617.1 - 0.011 15.9 0.0 0.025 14.7 0.0 1.7 2 0 0 2 2 2 0 Phosphotyrosine-binding domain RA PF00788.23 EFO65617.1 - 0.023 15.3 0.0 0.047 14.3 0.0 1.6 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain FERM_M PF00373.18 EFO65617.1 - 0.037 14.4 0.0 0.086 13.3 0.0 1.5 1 0 0 1 1 1 0 FERM central domain Fn3-like PF14310.6 EFO65617.1 - 0.045 13.9 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 Fibronectin type III-like domain PID PF00640.23 EFO65617.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 2 0 0 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) SpoU_methylase PF00588.19 EFO65618.1 - 1.1e-29 103.4 0.0 1.5e-29 103.0 0.0 1.1 1 0 0 1 1 1 1 SpoU rRNA Methylase family UPF0242 PF06785.11 EFO65619.1 - 0.00011 22.3 50.7 0.00069 19.8 9.7 5.4 4 1 2 6 6 5 4 Uncharacterised protein family (UPF0242) N-terminus PH_TFIIH PF08567.11 EFO65619.1 - 0.23 11.8 2.8 2.3 8.6 0.4 2.8 2 0 0 2 2 2 0 TFIIH p62 subunit, N-terminal domain Pox_A_type_inc PF04508.12 EFO65619.1 - 0.38 10.7 4.8 14 5.7 0.3 3.6 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat TSC22 PF01166.18 EFO65619.1 - 0.7 10.3 29.8 13 6.2 0.2 7.5 6 2 0 6 6 6 0 TSC-22/dip/bun family Tox-URI2 PF15653.6 EFO65619.1 - 1.5 9.1 5.2 5.7 7.3 0.5 3.1 2 0 0 2 2 2 0 URI fold toxin 2 TMF_TATA_bd PF12325.8 EFO65619.1 - 1.6 9.0 50.7 0.62 10.3 7.8 6.3 3 2 3 6 6 6 0 TATA element modulatory factor 1 TATA binding HMMR_N PF15905.5 EFO65619.1 - 2.2 7.7 48.0 0.06 12.8 3.3 3.6 3 1 0 3 3 3 0 Hyaluronan mediated motility receptor N-terminal ATG16 PF08614.11 EFO65619.1 - 2.4 8.3 57.9 4.1 7.6 18.4 5.5 2 2 3 5 5 5 0 Autophagy protein 16 (ATG16) RTBV_P46 PF06216.11 EFO65619.1 - 2.5 6.9 4.6 4.4 6.1 4.3 1.5 1 1 0 1 1 1 0 Rice tungro bacilliform virus P46 protein FAM76 PF16046.5 EFO65619.1 - 2.7 7.3 40.2 0.055 12.8 5.4 4.2 3 1 1 4 4 4 0 FAM76 protein DUF4407 PF14362.6 EFO65619.1 - 2.7 7.3 35.8 5.6 6.2 3.2 4.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4407) PRKG1_interact PF15898.5 EFO65619.1 - 3.3 8.6 45.3 0.86 10.5 0.1 4.8 3 1 0 4 4 4 0 cGMP-dependent protein kinase interacting domain Fib_alpha PF08702.10 EFO65619.1 - 3.5 7.8 39.9 0.32 11.2 4.0 4.7 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family HALZ PF02183.18 EFO65619.1 - 3.7 7.8 26.9 9 6.6 0.2 6.5 6 0 0 6 6 6 0 Homeobox associated leucine zipper Spc7 PF08317.11 EFO65619.1 - 5.3 5.8 50.0 0.084 11.7 5.8 4.3 3 1 1 4 4 4 0 Spc7 kinetochore protein YabA PF06156.13 EFO65619.1 - 6.1 7.5 50.7 1.1 9.9 1.1 7.1 3 2 3 6 6 6 0 Initiation control protein YabA DivIC PF04977.15 EFO65619.1 - 7.3 6.4 50.1 0.059 13.2 2.0 7.8 4 2 2 7 7 7 0 Septum formation initiator ELMO_CED12 PF04727.13 EFO65620.1 - 5.7e-09 36.3 0.0 1.8e-08 34.7 0.0 1.8 1 1 0 1 1 1 1 ELMO/CED-12 family Pkinase PF00069.25 EFO65621.1 - 2.4e-49 168.1 0.0 3.4e-49 167.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65621.1 - 6.3e-16 58.4 0.0 1e-15 57.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PAP_assoc PF03828.19 EFO65622.1 - 0.0003 20.9 0.0 0.00054 20.1 0.0 1.4 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EFO65622.1 - 0.012 15.9 0.0 0.042 14.1 0.0 1.9 2 0 0 2 2 2 0 Nucleotidyltransferase domain LRR_4 PF12799.7 EFO65623.1 - 6.8e-25 86.7 69.1 0.0025 18.2 0.7 13.9 8 4 5 15 15 15 11 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFO65623.1 - 1.3e-21 76.1 53.1 7e-07 28.9 0.0 10.9 7 3 4 11 11 11 10 Leucine rich repeat LRR_9 PF14580.6 EFO65623.1 - 7.7e-06 25.5 17.2 0.18 11.3 0.3 6.0 4 1 1 5 5 5 3 Leucine-rich repeat LRR_6 PF13516.6 EFO65623.1 - 5.9e-05 22.8 48.4 2 8.7 0.0 13.5 14 1 1 15 15 15 5 Leucine Rich repeat LRR_1 PF00560.33 EFO65623.1 - 0.045 14.3 46.0 4.8 8.1 0.0 14.2 14 2 1 15 15 15 0 Leucine Rich Repeat Histone PF00125.24 EFO65624.1 - 4.6e-12 46.4 0.4 5.9e-12 46.1 0.1 1.3 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFO65624.1 - 2.1e-10 40.7 0.0 3.2e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone_H2A_C PF16211.5 EFO65624.1 - 0.069 12.9 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 C-terminus of histone H2A TFIID-18kDa PF02269.16 EFO65624.1 - 0.12 12.4 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit Helicase_C PF00271.31 EFO65626.1 - 1.8e-09 37.9 0.0 4.9e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFO65626.1 - 3.1e-09 36.8 0.1 7e-09 35.7 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 EFO65626.1 - 6.9e-06 25.3 0.0 1.7e-05 24.1 0.0 1.6 2 0 0 2 2 2 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 EFO65626.1 - 0.00051 19.5 0.0 0.065 12.6 0.0 3.0 3 0 0 3 3 3 1 FtsK/SpoIIIE family AAA_29 PF13555.6 EFO65626.1 - 0.002 17.8 0.0 0.0048 16.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 EFO65626.1 - 0.011 15.4 0.0 0.024 14.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 EFO65626.1 - 0.022 14.8 0.0 6.6 6.7 0.0 2.3 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EFO65626.1 - 0.042 14.2 0.0 0.099 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain HA2 PF04408.23 EFO65626.1 - 0.043 14.1 0.0 0.097 13.0 0.0 1.6 1 0 0 1 1 1 0 Helicase associated domain (HA2) AAA_22 PF13401.6 EFO65626.1 - 0.084 13.1 0.2 0.34 11.2 0.2 2.1 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EFO65626.1 - 0.2 10.9 0.1 0.38 10.0 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin Kinesin PF00225.23 EFO65629.1 - 1.4e-103 346.4 0.0 2.5e-103 345.5 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFO65629.1 - 6.2e-22 78.1 0.3 6.2e-22 78.1 0.3 2.3 2 0 0 2 2 2 1 Microtubule binding HALZ PF02183.18 EFO65629.1 - 0.0023 18.1 4.3 0.0028 17.8 1.0 2.6 2 0 0 2 2 2 1 Homeobox associated leucine zipper AAA_7 PF12775.7 EFO65629.1 - 0.062 12.8 0.0 0.17 11.4 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region HIP1_clath_bdg PF16515.5 EFO65629.1 - 0.088 13.4 22.0 0.57 10.8 0.8 4.4 3 2 1 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF3496 PF12001.8 EFO65629.1 - 0.13 12.6 3.3 8 6.9 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3496) Cbl_N PF02262.16 EFO65629.1 - 0.16 11.9 4.4 0.32 11.0 0.8 3.1 3 0 0 3 3 3 0 CBL proto-oncogene N-terminal domain 1 Fez1 PF06818.15 EFO65629.1 - 3.8 7.9 16.8 0.11 13.0 5.9 2.9 2 1 1 3 3 3 0 Fez1 HrpB7 PF09486.10 EFO65629.1 - 5.6 7.3 12.3 2.2 8.6 1.4 3.5 3 1 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) Tfb2 PF03849.14 EFO65631.1 - 1.9e-11 43.6 0.3 3.8e-11 42.6 0.3 1.4 1 0 0 1 1 1 1 Transcription factor Tfb2 PAN_2 PF08276.11 EFO65631.1 - 0.12 12.5 0.1 0.32 11.2 0.1 1.7 1 0 0 1 1 1 0 PAN-like domain Spc7 PF08317.11 EFO65632.1 - 0.00077 18.4 103.2 0.008 15.1 19.2 6.2 1 1 4 6 6 6 6 Spc7 kinetochore protein YabA PF06156.13 EFO65632.1 - 0.012 16.3 7.0 0.012 16.3 7.0 10.0 3 1 5 8 8 8 0 Initiation control protein YabA KASH_CCD PF14662.6 EFO65632.1 - 0.042 13.7 109.0 0.27 11.0 18.2 5.8 1 1 3 5 5 5 0 Coiled-coil region of CCDC155 or KASH CENP-F_leu_zip PF10473.9 EFO65632.1 - 0.52 10.3 113.1 0.58 10.2 7.5 8.2 2 1 4 7 7 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 YnfE PF17452.2 EFO65632.1 - 2.7 8.4 10.1 0.67 10.3 1.9 3.8 2 1 0 2 2 2 0 Uncharacterized YnfE-like APG6_N PF17675.1 EFO65632.1 - 3.8 8.1 108.5 0.93 10.0 21.1 7.9 1 1 5 6 6 6 0 Apg6 coiled-coil region Cpn60_TCP1 PF00118.24 EFO65634.1 - 7.4e-158 526.2 4.9 8.4e-158 526.0 4.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Fez1 PF06818.15 EFO65635.1 - 0.016 15.7 12.5 0.027 14.9 4.8 2.4 2 0 0 2 2 2 0 Fez1 YabA PF06156.13 EFO65635.1 - 0.23 12.1 17.5 0.82 10.3 1.5 3.6 3 1 1 4 4 3 0 Initiation control protein YabA DUF4201 PF13870.6 EFO65635.1 - 0.29 10.9 20.5 3.2 7.4 9.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) SHE3 PF17078.5 EFO65635.1 - 0.29 10.8 13.3 0.31 10.7 4.0 2.6 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 Filament PF00038.21 EFO65635.1 - 0.29 10.7 16.6 0.25 10.9 0.9 2.5 2 1 0 2 2 2 0 Intermediate filament protein Atg14 PF10186.9 EFO65635.1 - 0.37 9.8 16.7 0.065 12.3 5.5 3.1 3 0 0 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 SOGA PF11365.8 EFO65635.1 - 0.49 11.6 9.0 0.22 12.7 2.8 3.1 3 0 0 3 3 2 0 Protein SOGA CENP-F_leu_zip PF10473.9 EFO65635.1 - 0.82 9.7 20.7 1.7 8.7 11.5 2.7 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ZapB PF06005.12 EFO65635.1 - 0.9 10.0 21.7 1.4 9.4 3.0 3.3 3 0 0 3 3 3 0 Cell division protein ZapB Spc7 PF08317.11 EFO65635.1 - 0.94 8.3 15.1 0.51 9.2 6.7 2.5 3 0 0 3 3 3 0 Spc7 kinetochore protein DUF4407 PF14362.6 EFO65635.1 - 1.3 8.3 11.7 0.97 8.7 6.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DivIC PF04977.15 EFO65635.1 - 1.8 8.4 20.2 6.7 6.6 0.1 4.3 3 1 1 4 4 4 0 Septum formation initiator YscO PF07321.12 EFO65635.1 - 1.9 8.4 18.5 0.074 13.0 10.5 2.1 2 0 0 2 2 2 0 Type III secretion protein YscO APG6_N PF17675.1 EFO65635.1 - 2.5 8.6 20.5 14 6.2 0.4 3.1 2 1 0 2 2 2 0 Apg6 coiled-coil region TolA_bind_tri PF16331.5 EFO65635.1 - 2.8 8.1 13.8 2.5 8.3 1.7 4.3 3 2 0 3 3 3 0 TolA binding protein trimerisation GAS PF13851.6 EFO65635.1 - 3.5 6.9 18.9 0.3 10.4 8.8 2.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding UPF0242 PF06785.11 EFO65635.1 - 3.6 7.7 17.3 12 5.9 0.9 3.0 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Cnn_1N PF07989.11 EFO65635.1 - 4 7.7 15.9 12 6.1 6.0 3.4 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 Spectrin PF00435.21 EFO65635.1 - 4.1 8.0 12.3 0.34 11.4 0.6 2.5 2 0 0 2 2 2 0 Spectrin repeat HALZ PF02183.18 EFO65635.1 - 6.3 7.1 13.2 6.8 7.0 0.5 4.4 4 0 0 4 4 4 0 Homeobox associated leucine zipper DUF2968 PF11180.8 EFO65635.1 - 7 6.2 13.5 1.8 8.2 6.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) DUF4763 PF15960.5 EFO65635.1 - 7.3 5.8 11.8 0.22 10.8 3.2 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4763) PRKG1_interact PF15898.5 EFO65635.1 - 7.6 7.5 21.6 24 5.9 11.3 3.5 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain ADIP PF11559.8 EFO65635.1 - 8.2 6.5 20.6 2.2 8.4 9.6 2.6 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DnaJ PF00226.31 EFO65636.1 - 1.9e-15 56.7 1.7 1.9e-15 56.7 1.7 1.9 2 0 0 2 2 1 1 DnaJ domain TPR_1 PF00515.28 EFO65636.1 - 1.8e-13 49.7 9.0 9e-06 25.3 0.1 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFO65636.1 - 7.1e-12 44.5 9.1 0.00013 21.8 0.0 6.4 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFO65636.1 - 3.9e-07 30.5 6.1 0.07 13.7 0.2 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFO65636.1 - 2.9e-05 24.3 10.9 2.7 8.3 0.1 5.0 3 1 1 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFO65636.1 - 7.5e-05 23.3 5.9 0.00025 21.6 0.0 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFO65636.1 - 0.00079 19.3 0.4 1.6 8.9 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat NYD-SP12_N PF15015.6 EFO65636.1 - 0.0022 16.5 0.1 0.84 7.9 0.0 2.2 2 0 0 2 2 2 2 Spermatogenesis-associated, N-terminal TPR_8 PF13181.6 EFO65636.1 - 0.012 15.8 8.6 1.5 9.2 0.0 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFO65636.1 - 0.013 15.2 1.4 0.013 15.2 1.4 3.9 3 1 0 3 3 3 0 TPR repeat TPR_14 PF13428.6 EFO65636.1 - 0.019 15.7 5.2 26 6.0 0.0 5.4 6 1 0 6 6 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFO65636.1 - 0.42 10.5 5.4 27 4.8 0.2 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFO65636.1 - 8.1 6.8 17.0 0.47 10.7 0.8 4.4 4 2 2 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 Lyase_8 PF02278.18 EFO65638.1 - 5.1e-19 68.8 1.7 3.1e-18 66.2 0.4 2.2 2 0 0 2 2 2 1 Polysaccharide lyase family 8, super-sandwich domain Lyase_8_N PF08124.11 EFO65638.1 - 1.1e-11 44.2 3.3 6.2e-11 41.8 3.3 2.0 1 1 0 1 1 1 1 Polysaccharide lyase family 8, N terminal alpha-helical domain Lyase_8_C PF02884.17 EFO65638.1 - 4.6e-06 27.0 1.7 1.3e-05 25.6 0.3 2.4 2 0 0 2 2 2 1 Polysaccharide lyase family 8, C-terminal beta-sandwich domain Euplotes_phero PF05842.11 EFO65640.1 - 5.9 7.5 10.5 0.071 13.7 0.7 2.8 4 0 0 4 4 4 0 Euplotes octocarinatus mating pheromone protein Ank_2 PF12796.7 EFO65641.1 - 1.4e-88 291.6 32.4 5.1e-10 39.8 0.0 15.4 6 4 14 20 20 20 17 Ankyrin repeats (3 copies) Ank PF00023.30 EFO65641.1 - 6.9e-44 146.4 27.5 0.00019 21.7 0.0 21.6 21 2 1 22 22 22 12 Ankyrin repeat Ank_4 PF13637.6 EFO65641.1 - 5.1e-41 138.5 21.7 0.00062 20.3 0.0 15.7 12 4 4 16 16 16 11 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO65641.1 - 4.6e-40 135.2 21.9 0.00068 19.9 0.0 15.5 12 4 5 17 17 17 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65641.1 - 7.7e-35 115.0 29.8 0.085 13.5 0.1 20.6 23 0 0 23 23 23 12 Ankyrin repeat PI3_PI4_kinase PF00454.27 EFO65642.1 - 6.1e-28 98.3 0.0 1.8e-17 64.0 0.0 2.5 2 0 0 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFO65642.1 - 8.2e-10 38.4 1.1 0.0012 18.3 0.4 2.5 2 0 0 2 2 2 2 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 EFO65642.1 - 1.4e-06 28.3 0.0 3.9e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 tRNA-synt_1b PF00579.25 EFO65644.1 - 2e-28 99.5 0.0 9.1e-17 61.3 0.0 2.4 2 1 1 3 3 3 2 tRNA synthetases class I (W and Y) PP2C PF00481.21 EFO65645.1 - 6.1e-18 65.4 0.2 6.2e-07 29.3 0.0 3.2 3 0 0 3 3 3 3 Protein phosphatase 2C OST_IS PF18246.1 EFO65645.1 - 0.026 14.8 0.0 8.4 6.8 0.0 2.5 2 0 0 2 2 2 0 Oligosaccharyltransferase Insert domain RNA_pol_L_2 PF13656.6 EFO65646.1 - 1.2e-18 66.6 0.1 1.6e-18 66.2 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EFO65646.1 - 1.2e-09 37.5 0.0 1.8e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain s48_45 PF07422.13 EFO65646.1 - 0.073 13.6 0.0 0.082 13.5 0.0 1.2 1 0 0 1 1 1 0 Sexual stage antigen s48/45 domain Myb_DNA-binding PF00249.31 EFO65647.1 - 6.4e-06 26.3 0.0 1.2e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFO65647.1 - 0.011 15.9 0.1 0.039 14.2 0.1 2.0 1 1 1 2 2 2 0 Myb-like DNA-binding domain DUF4635 PF15466.6 EFO65647.1 - 0.016 14.7 1.4 0.035 13.6 0.1 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4635) Myb_DNA-bind_7 PF15963.5 EFO65647.1 - 0.09 12.7 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 Myb DNA-binding like HMG-CoA_red PF00368.18 EFO65648.1 - 5.2e-62 210.0 0.3 7.5e-62 209.4 0.3 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase DUF2095 PF09868.9 EFO65648.1 - 0.022 14.7 0.0 0.7 9.9 0.0 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2095) tRNA_edit PF04073.15 EFO65649.1 - 0.00055 20.0 0.0 0.0017 18.4 0.0 2.0 1 1 0 1 1 1 1 Aminoacyl-tRNA editing domain TUDOR_5 PF18359.1 EFO65650.1 - 0.085 12.6 0.1 0.18 11.5 0.1 1.6 1 0 0 1 1 1 0 Histone methyltransferase Tudor domain 1 Arf PF00025.21 EFO65651.1 - 1.5e-52 177.5 0.0 1.7e-52 177.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFO65651.1 - 1.3e-10 41.0 0.1 1.6e-10 40.7 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFO65651.1 - 2.9e-10 39.8 0.4 8.8e-08 31.7 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EFO65651.1 - 1.2e-09 38.0 0.0 1.4e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EFO65651.1 - 2.1e-09 37.5 0.0 2.8e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EFO65651.1 - 1.2e-08 35.2 0.0 2.5e-08 34.1 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EFO65651.1 - 0.00019 21.4 0.1 0.075 12.9 0.1 2.1 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EFO65651.1 - 0.0012 18.3 0.0 0.0013 18.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Dynamin_N PF00350.23 EFO65651.1 - 0.0089 16.1 0.1 3.7 7.6 0.0 2.2 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 EFO65651.1 - 0.018 14.6 0.0 0.95 9.0 0.0 2.0 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EFO65651.1 - 0.021 15.1 0.1 0.046 14.0 0.1 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFO65651.1 - 0.061 13.8 0.1 0.097 13.2 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 EFO65651.1 - 0.097 13.0 0.4 0.39 11.1 0.4 1.8 1 1 0 1 1 1 0 AAA ATPase domain Ank_2 PF12796.7 EFO65653.1 - 2e-49 166.1 5.9 4.4e-14 52.8 0.0 5.1 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EFO65653.1 - 1.8e-28 97.7 9.4 3.3e-05 24.1 0.4 8.6 8 1 1 9 9 9 7 Ankyrin repeat Ank_3 PF13606.6 EFO65653.1 - 2.1e-27 92.1 2.5 0.022 15.2 0.0 8.5 9 0 0 9 9 9 6 Ankyrin repeat Ank_4 PF13637.6 EFO65653.1 - 2.2e-22 79.1 5.9 0.00017 22.1 0.1 6.2 4 2 3 7 7 7 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO65653.1 - 8.5e-22 76.9 7.0 0.0011 19.2 0.0 6.6 2 2 5 7 7 7 6 Ankyrin repeats (many copies) NMT1_2 PF13379.6 EFO65653.1 - 0.003 17.3 5.9 3 7.5 0.2 3.9 1 1 3 4 4 4 3 NMT1-like family Phage_T7_Capsid PF05396.11 EFO65653.1 - 0.017 15.5 0.1 0.047 14.1 0.1 1.7 1 0 0 1 1 1 0 Phage T7 capsid assembly protein YlzJ PF14035.6 EFO65653.1 - 0.15 12.3 0.0 2.4 8.4 0.0 2.6 3 0 0 3 3 3 0 YlzJ-like protein APC_rep PF18797.1 EFO65654.1 - 0.0079 17.1 0.1 0.91 10.5 0.1 2.5 2 0 0 2 2 2 1 Adenomatous polyposis coli (APC) repeat EVC2_like PF12297.8 EFO65654.1 - 0.33 9.6 6.0 0.44 9.2 6.0 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein MMS19_N PF14500.6 EFO65655.1 - 0.0001 22.0 4.7 0.00015 21.4 0.2 3.1 3 0 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II AlbA_2 PF04326.14 EFO65656.1 - 1.9e-17 63.7 1.2 1.5e-16 60.9 0.0 2.5 3 0 0 3 3 3 1 Putative DNA-binding domain zf-C2H2_4 PF13894.6 EFO65657.1 - 0.00014 22.4 9.9 0.088 13.7 1.0 3.9 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFO65657.1 - 0.00015 21.9 1.3 0.008 16.4 0.9 3.2 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFO65657.1 - 0.0017 18.6 2.3 3.7 8.1 0.9 3.5 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 EFO65657.1 - 0.0049 16.6 2.8 0.02 14.6 0.7 2.6 2 0 0 2 2 2 1 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 EFO65657.1 - 0.021 15.1 5.0 0.88 9.9 1.2 3.0 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 EFO65657.1 - 0.1 12.5 4.8 6.5 6.7 0.1 3.2 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-C2H2 PF00096.26 EFO65657.1 - 0.29 11.7 12.7 12 6.5 1.2 3.8 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-Di19 PF05605.12 EFO65657.1 - 0.98 9.8 7.8 1 9.7 0.3 3.1 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Zn-C2H2_12 PF18112.1 EFO65657.1 - 0.99 9.9 4.4 0.55 10.7 0.4 2.5 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain Peptidase_C1 PF00112.23 EFO65659.1 - 4e-48 164.4 1.4 4.7e-48 164.1 1.4 1.0 1 0 0 1 1 1 1 Papain family cysteine protease FANC_SAP PF18081.1 EFO65659.1 - 0.15 12.2 0.6 0.26 11.5 0.6 1.3 1 0 0 1 1 1 0 Fanconi anemia-associated nuclease SAP domain Peptidase_C1_2 PF03051.15 EFO65659.1 - 0.21 10.3 0.3 0.31 9.8 0.3 1.1 1 0 0 1 1 1 0 Peptidase C1-like family SNF2_N PF00176.23 EFO65660.1 - 5.7e-60 202.9 0.9 2.2e-59 201.0 0.9 2.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 EFO65660.1 - 5.7e-28 97.2 0.2 1.5e-27 95.9 0.2 1.8 1 0 0 1 1 1 1 SLIDE Helicase_C PF00271.31 EFO65660.1 - 2.2e-15 57.0 0.1 9.7e-15 54.9 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFO65660.1 - 5.9e-05 23.1 0.5 0.00016 21.7 0.1 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ABC_tran PF00005.27 EFO65661.1 - 1.9e-26 93.2 0.0 3.7e-26 92.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFO65661.1 - 8.2e-12 45.5 0.1 3.7e-07 30.3 0.0 3.1 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EFO65661.1 - 5.4e-10 38.9 15.4 8.9e-10 38.2 15.4 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane PF01061.24 EFO65661.1 - 8.2e-06 25.4 19.3 0.004 16.6 16.3 2.5 2 0 0 2 2 2 2 ABC-2 type transporter AAA_27 PF13514.6 EFO65661.1 - 0.013 15.1 0.0 1.3 8.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 EFO65661.1 - 0.043 13.6 1.9 0.29 10.9 0.1 2.9 3 0 0 3 3 3 0 P-loop containing region of AAA domain SMC_N PF02463.19 EFO65661.1 - 0.046 13.2 0.0 5.2 6.4 0.0 2.3 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFO65661.1 - 0.074 13.5 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF4162 PF13732.6 EFO65661.1 - 0.12 13.1 0.0 0.23 12.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4162) AAA_16 PF13191.6 EFO65661.1 - 0.18 12.2 0.0 0.38 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Ank_2 PF12796.7 EFO65662.1 - 1.4e-116 381.3 30.5 1.6e-14 54.3 0.1 13.2 3 1 7 12 12 12 11 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO65662.1 - 8.9e-61 201.5 28.0 2.9e-06 27.7 0.1 16.3 11 4 7 18 18 18 15 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO65662.1 - 1e-53 178.7 37.7 0.0001 22.5 0.1 19.9 8 7 13 21 21 21 16 Ankyrin repeats (many copies) Ank PF00023.30 EFO65662.1 - 2.6e-49 163.6 28.3 0.011 16.1 0.0 23.0 23 1 1 24 24 24 13 Ankyrin repeat Ank_3 PF13606.6 EFO65662.1 - 5.7e-45 146.1 28.2 0.29 11.8 0.0 24.3 26 0 0 26 26 26 12 Ankyrin repeat Pkinase PF00069.25 EFO65662.1 - 2.4e-27 95.9 0.0 4.9e-27 95.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65662.1 - 5.9e-12 45.4 0.0 1.2e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase DapB_C PF05173.14 EFO65662.1 - 0.11 12.5 0.1 1.8 8.6 0.0 2.8 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, C-terminus ER_lumen_recept PF00810.18 EFO65663.1 - 3.9e-44 151.0 13.2 5.3e-44 150.6 13.2 1.2 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EFO65663.1 - 0.019 14.7 13.6 0.074 12.8 0.4 3.6 3 1 1 4 4 4 0 PQ loop repeat WD40 PF00400.32 EFO65664.1 - 8.6e-09 35.9 19.3 0.0008 20.2 0.5 6.6 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO65664.1 - 8.3e-05 22.8 0.8 0.52 10.7 0.1 4.3 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Thioredoxin PF00085.20 EFO65665.1 - 1.2e-31 108.7 0.0 1.5e-31 108.5 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 EFO65665.1 - 2.4e-05 24.4 0.0 3.4e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EFO65665.1 - 2.6e-05 24.6 0.1 0.00014 22.3 0.1 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 EFO65665.1 - 0.0057 16.6 0.0 0.0068 16.3 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 EFO65665.1 - 0.0086 16.4 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 EFO65665.1 - 0.035 13.8 0.0 0.037 13.7 0.0 1.2 1 0 0 1 1 1 0 Redoxin Not3 PF04065.15 EFO65667.1 - 7.1e-45 153.2 13.3 1.3e-44 152.4 13.3 1.4 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component IL11 PF07400.11 EFO65667.1 - 0.018 14.7 1.0 0.076 12.7 1.0 2.0 1 1 0 1 1 1 0 Interleukin 11 YlqD PF11068.8 EFO65667.1 - 1.2 9.6 12.0 10 6.5 0.6 2.9 2 0 0 2 2 2 0 YlqD protein Ribosomal_L13e PF01294.18 EFO65668.1 - 7.5e-46 156.2 3.0 7.5e-46 156.2 3.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L13e BRCA2 PF00634.18 EFO65668.1 - 0.39 10.4 1.7 0.67 9.7 0.3 2.2 2 0 0 2 2 2 0 BRCA2 repeat Auto_anti-p27 PF06677.12 EFO65670.1 - 2.1e-12 47.0 9.0 1.7e-10 40.9 0.9 2.6 2 0 0 2 2 2 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DZR PF12773.7 EFO65670.1 - 0.0068 16.4 6.3 0.035 14.1 0.8 2.6 2 0 0 2 2 2 1 Double zinc ribbon Lar_restr_allev PF14354.6 EFO65670.1 - 0.06 13.7 6.2 3.8 8.0 1.5 2.7 3 0 0 3 3 3 0 Restriction alleviation protein Lar DUF1451 PF07295.11 EFO65670.1 - 0.36 10.9 5.6 6.1 6.9 0.2 2.6 3 0 0 3 3 3 0 Zinc-ribbon containing domain zf-dskA_traR PF01258.17 EFO65670.1 - 1.3 9.0 5.5 3.9 7.5 0.1 3.2 3 0 0 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger zf-ribbon_3 PF13248.6 EFO65670.1 - 2.2 7.8 6.0 22 4.6 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain C1_1 PF00130.22 EFO65670.1 - 3.2 7.7 6.0 0.75 9.7 0.7 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Ribosomal_S6e PF01092.19 EFO65672.1 - 2.5e-45 153.5 0.1 6e-45 152.2 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein S6e FliT PF05400.13 EFO65672.1 - 0.085 13.7 2.3 0.21 12.4 2.0 1.7 1 1 0 2 2 2 0 Flagellar protein FliT LAGLIDADG_3 PF14528.6 EFO65672.1 - 0.4 11.0 1.6 5.4 7.4 0.2 2.7 2 1 1 3 3 3 0 LAGLIDADG-like domain RTTN_N PF14726.6 EFO65674.1 - 0.043 14.6 0.0 0.11 13.3 0.0 1.7 1 0 0 1 1 1 0 Rotatin, an armadillo repeat protein, centriole functioning Med26 PF08711.11 EFO65677.1 - 1.2e-07 31.6 0.0 2.7e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain DUF4519 PF15012.6 EFO65677.1 - 0.38 10.9 2.9 0.69 10.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) OmpA PF00691.20 EFO65678.1 - 0.11 12.9 0.0 0.11 12.8 0.0 1.1 1 0 0 1 1 1 0 OmpA family AAA_2 PF07724.14 EFO65679.1 - 2.9e-48 164.2 0.0 1.3e-45 155.6 0.0 3.0 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EFO65679.1 - 1e-28 99.3 0.3 1e-28 99.3 0.3 2.9 1 1 2 3 3 3 1 AAA lid domain AAA PF00004.29 EFO65679.1 - 4.8e-25 88.5 0.1 1.9e-13 51.0 0.0 3.0 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EFO65679.1 - 4.4e-15 55.5 3.7 8.4e-15 54.6 0.3 3.3 3 0 0 3 3 2 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EFO65679.1 - 6.8e-15 55.3 0.7 4e-10 39.8 0.0 4.1 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFO65679.1 - 7.7e-12 45.9 8.2 9.8e-07 29.3 0.0 5.2 3 3 0 3 3 2 2 AAA ATPase domain Sigma54_activat PF00158.26 EFO65679.1 - 3.7e-11 43.0 0.0 3e-07 30.3 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_14 PF13173.6 EFO65679.1 - 7.2e-11 42.2 0.0 0.00032 20.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EFO65679.1 - 2e-10 41.0 0.3 0.002 18.4 0.0 3.9 3 2 0 3 3 2 2 AAA domain Clp_N PF02861.20 EFO65679.1 - 4.7e-09 36.2 0.8 0.0006 19.9 0.0 3.2 3 0 0 3 3 2 2 Clp amino terminal domain, pathogenicity island component ATPase_2 PF01637.18 EFO65679.1 - 1.5e-08 34.9 5.9 0.00035 20.6 0.0 4.2 3 2 1 4 4 3 2 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EFO65679.1 - 4.8e-08 32.9 0.0 0.0017 18.1 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein TniB PF05621.11 EFO65679.1 - 5.5e-08 32.4 0.0 2.3e-05 23.9 0.0 3.8 3 1 0 3 3 3 1 Bacterial TniB protein AAA_18 PF13238.6 EFO65679.1 - 3.5e-07 30.8 0.3 0.025 15.1 0.0 3.7 3 0 0 3 3 3 2 AAA domain AAA_7 PF12775.7 EFO65679.1 - 1.9e-06 27.5 0.0 0.0052 16.3 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region RuvB_N PF05496.12 EFO65679.1 - 2.6e-06 27.3 1.8 0.14 11.9 0.0 4.0 3 1 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 EFO65679.1 - 5.7e-06 26.4 0.0 0.19 11.6 0.0 2.8 3 0 0 3 3 2 2 NACHT domain RsgA_GTPase PF03193.16 EFO65679.1 - 6.4e-06 26.2 0.0 0.049 13.5 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase RNA_helicase PF00910.22 EFO65679.1 - 4.9e-05 23.7 0.0 0.26 11.7 0.0 3.3 3 0 0 3 3 2 2 RNA helicase Torsin PF06309.11 EFO65679.1 - 7.4e-05 22.9 0.0 0.00026 21.1 0.0 1.9 2 0 0 2 2 1 1 Torsin AAA_33 PF13671.6 EFO65679.1 - 0.00012 22.3 0.2 0.21 11.8 0.0 3.5 2 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EFO65679.1 - 0.00015 21.2 0.1 1.2 8.5 0.0 3.5 2 2 0 2 2 2 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EFO65679.1 - 0.00022 21.2 0.0 1 9.3 0.0 2.6 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 EFO65679.1 - 0.00024 21.6 0.7 2.2 8.7 1.1 3.6 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 EFO65679.1 - 0.00027 20.2 0.0 0.085 12.0 0.0 2.8 2 1 0 2 2 2 1 NB-ARC domain ABC_tran PF00005.27 EFO65679.1 - 0.00029 21.3 0.5 0.15 12.6 0.0 3.6 3 1 0 3 3 3 1 ABC transporter AAA_28 PF13521.6 EFO65679.1 - 0.00043 20.6 5.5 0.4 10.9 0.1 4.2 3 2 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EFO65679.1 - 0.0005 19.8 0.3 0.02 14.6 0.0 3.1 3 0 0 3 3 2 1 AAA domain DUF87 PF01935.17 EFO65679.1 - 0.00072 19.7 0.8 0.038 14.1 0.0 3.0 3 0 0 3 3 2 1 Helicase HerA, central domain AAA_3 PF07726.11 EFO65679.1 - 0.0011 18.9 0.1 0.045 13.6 0.0 3.3 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EFO65679.1 - 0.0012 18.1 0.1 0.044 13.1 0.0 3.0 3 0 0 3 3 2 1 Zeta toxin LUC7 PF03194.15 EFO65679.1 - 0.0022 17.7 2.8 0.0051 16.5 2.8 1.6 1 0 0 1 1 1 1 LUC7 N_terminus NTPase_1 PF03266.15 EFO65679.1 - 0.0026 17.7 0.0 0.89 9.5 0.0 3.4 3 0 0 3 3 3 1 NTPase AAA_24 PF13479.6 EFO65679.1 - 0.0028 17.4 0.0 0.97 9.1 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_19 PF13245.6 EFO65679.1 - 0.0029 18.0 0.0 0.52 10.6 0.0 3.1 3 0 0 3 3 2 1 AAA domain Roc PF08477.13 EFO65679.1 - 0.0055 16.9 0.0 1.2 9.4 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase T2SSE PF00437.20 EFO65679.1 - 0.007 15.5 0.0 1.4 7.9 0.0 2.8 3 0 0 3 3 2 1 Type II/IV secretion system protein AAA_21 PF13304.6 EFO65679.1 - 0.0082 16.0 2.3 6.4 6.5 0.0 3.9 4 1 1 5 5 5 0 AAA domain, putative AbiEii toxin, Type IV TA system NPV_P10 PF05531.12 EFO65679.1 - 0.01 16.3 1.4 0.23 12.0 0.2 3.0 2 0 0 2 2 2 1 Nucleopolyhedrovirus P10 protein Bac_DnaA PF00308.18 EFO65679.1 - 0.012 15.4 0.1 8.7 6.1 0.0 2.9 3 0 0 3 3 2 0 Bacterial dnaA protein AAA_29 PF13555.6 EFO65679.1 - 0.013 15.2 0.1 2.6 7.9 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.18 EFO65679.1 - 0.016 14.9 0.0 5.3 6.7 0.0 2.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 EFO65679.1 - 0.021 14.3 0.0 6.1 6.2 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein ResIII PF04851.15 EFO65679.1 - 0.025 14.6 0.0 41 4.1 0.0 3.7 4 0 0 4 4 3 0 Type III restriction enzyme, res subunit TIP49 PF06068.13 EFO65679.1 - 0.028 13.7 2.6 4.7 6.3 0.0 3.3 3 1 1 4 4 4 0 TIP49 P-loop domain BLOC1_2 PF10046.9 EFO65679.1 - 0.032 14.5 2.6 0.047 14.0 0.7 2.3 2 0 0 2 2 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ABC_tran_CTD PF16326.5 EFO65679.1 - 0.07 13.4 5.8 0.093 13.0 0.6 3.2 2 0 0 2 2 2 0 ABC transporter C-terminal domain Parvo_NS1 PF01057.17 EFO65679.1 - 0.14 11.2 0.0 13 4.8 0.0 2.3 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 FliT PF05400.13 EFO65679.1 - 0.25 12.2 9.5 2.6 8.9 0.0 4.1 3 1 0 3 3 2 0 Flagellar protein FliT RPW8 PF05659.11 EFO65679.1 - 0.36 10.5 5.5 0.37 10.5 0.8 3.0 3 0 0 3 3 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF2508 PF10704.9 EFO65679.1 - 2.4 8.4 5.5 11 6.3 0.0 3.1 3 0 0 3 3 2 0 Protein of unknown function (DUF2508) Pkinase PF00069.25 EFO65680.1 - 4.7e-58 196.6 0.0 8.8e-58 195.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65680.1 - 3.1e-38 131.6 0.0 5.2e-38 130.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFO65680.1 - 6.8e-31 106.7 4.8 1.8e-18 66.9 0.7 3.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFO65680.1 - 4.6e-18 64.8 1.4 1.7e-06 28.2 0.1 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EFO65680.1 - 3.2e-15 56.0 3.2 4.2e-05 23.7 0.1 3.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO65680.1 - 1.1e-14 54.6 2.3 1.3e-09 38.3 0.1 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65680.1 - 3e-09 36.3 1.7 0.051 14.1 0.0 4.6 3 1 1 4 4 4 3 Ankyrin repeat Pkinase_fungal PF17667.1 EFO65680.1 - 0.01 14.6 0.0 0.019 13.7 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 EFO65680.1 - 0.013 14.8 0.0 0.026 13.9 0.0 1.5 1 0 0 1 1 1 0 Kinase-like ABC1 PF03109.16 EFO65680.1 - 0.022 14.9 0.0 0.69 10.1 0.0 2.5 2 0 0 2 2 2 0 ABC1 family Ank_2 PF12796.7 EFO65682.1 - 6.8e-26 90.7 4.0 9.2e-09 35.8 0.1 4.0 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO65682.1 - 1.7e-16 60.1 3.0 2.3e-05 24.6 0.1 5.7 2 2 5 7 7 7 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO65682.1 - 5.7e-14 51.8 2.9 0.0068 16.8 0.0 6.1 5 1 1 6 6 6 3 Ankyrin repeat Ank_4 PF13637.6 EFO65682.1 - 5.7e-13 49.1 0.6 7.5e-05 23.2 0.0 4.6 3 1 2 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65682.1 - 2.2e-10 39.8 2.3 0.0087 16.5 0.0 5.5 6 0 0 6 6 6 3 Ankyrin repeat VSP PF03302.13 EFO65684.1 - 1.3e-83 281.1 226.6 1.2e-44 152.8 27.1 7.5 1 1 5 6 6 6 5 Giardia variant-specific surface protein Ank_2 PF12796.7 EFO65685.1 - 2.9e-132 431.6 22.8 7e-20 71.4 0.0 13.0 1 1 11 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO65685.1 - 2.1e-78 257.7 20.0 6.2e-10 39.4 0.0 18.2 13 4 4 17 17 17 14 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO65685.1 - 4.7e-72 237.1 33.9 2e-07 31.1 0.0 19.0 5 4 13 20 20 20 16 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65685.1 - 1.7e-70 224.5 25.3 0.00077 19.7 0.0 25.0 25 1 1 26 26 25 14 Ankyrin repeat Ank PF00023.30 EFO65685.1 - 8.3e-65 212.6 29.3 0.00014 22.1 0.0 23.3 23 1 1 24 24 24 12 Ankyrin repeat Pkinase PF00069.25 EFO65685.1 - 7.6e-23 81.2 0.0 1.4e-22 80.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65685.1 - 1.1e-16 60.9 0.0 1.8e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase TolA_bind_tri PF16331.5 EFO65685.1 - 8.4e-05 22.6 0.2 0.0002 21.4 0.2 1.7 1 0 0 1 1 1 1 TolA binding protein trimerisation HrpB7 PF09486.10 EFO65685.1 - 0.0014 19.1 1.8 0.0051 17.2 1.8 2.0 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB7) Spc7 PF08317.11 EFO65685.1 - 0.0024 16.8 0.3 0.004 16.1 0.3 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein BRE1 PF08647.11 EFO65685.1 - 0.0034 17.4 0.2 0.0093 16.0 0.2 1.7 1 0 0 1 1 1 1 BRE1 E3 ubiquitin ligase Fez1 PF06818.15 EFO65685.1 - 0.025 15.0 0.3 0.048 14.1 0.3 1.4 1 0 0 1 1 1 0 Fez1 XhlA PF10779.9 EFO65685.1 - 0.032 14.5 0.9 0.47 10.7 0.6 2.4 1 1 0 2 2 2 0 Haemolysin XhlA CEP63 PF17045.5 EFO65685.1 - 0.062 13.2 0.2 0.11 12.4 0.2 1.3 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa CENP-F_leu_zip PF10473.9 EFO65685.1 - 0.1 12.6 0.5 0.21 11.6 0.5 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Striatin PF08232.12 EFO65685.1 - 0.15 12.6 0.4 0.32 11.6 0.4 1.5 1 0 0 1 1 1 0 Striatin family DivIC PF04977.15 EFO65685.1 - 0.69 9.7 2.2 1.4 8.7 2.2 1.4 1 0 0 1 1 1 0 Septum formation initiator RVT_1 PF00078.27 EFO65686.1 - 4.5e-25 88.5 0.0 6.7e-25 87.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.6 EFO65686.1 - 4.7e-06 27.0 0.4 0.012 16.4 0.2 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EFO65686.1 - 0.013 16.0 2.3 0.094 13.2 1.1 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EFO65686.1 - 0.044 14.1 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 EFO65686.1 - 0.12 12.7 0.2 0.36 11.2 0.2 1.8 1 0 0 1 1 1 0 C2H2-type zinc ribbon GAGA PF09237.11 EFO65686.1 - 0.24 11.2 2.2 0.25 11.2 0.2 2.1 2 0 0 2 2 2 0 GAGA factor zf-C2H2_2 PF12756.7 EFO65686.1 - 0.3 11.4 1.7 0.51 10.7 0.0 2.1 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) RVT_1 PF00078.27 EFO65687.1 - 3.6e-22 79.0 0.0 4.8e-22 78.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.6 EFO65687.1 - 0.00041 21.0 5.8 0.41 11.6 0.4 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EFO65687.1 - 0.03 14.3 3.8 0.089 12.8 0.9 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_12 PF18658.1 EFO65687.1 - 0.044 13.4 0.5 0.17 11.5 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger C2H2-type zf-C2H2 PF00096.26 EFO65687.1 - 0.045 14.2 3.4 1.8 9.2 1.6 3.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EFO65687.1 - 0.12 12.6 0.0 0.72 10.2 0.0 2.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 EFO65687.1 - 0.18 11.5 0.0 0.38 10.4 0.0 1.5 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain RVT_1 PF00078.27 EFO65688.1 - 8.1e-24 84.4 0.0 1.1e-23 84.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.6 EFO65688.1 - 0.00041 21.0 5.8 0.41 11.6 0.4 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EFO65688.1 - 0.03 14.3 3.8 0.089 12.8 0.9 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_12 PF18658.1 EFO65688.1 - 0.044 13.4 0.5 0.17 11.5 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger C2H2-type zf-C2H2 PF00096.26 EFO65688.1 - 0.045 14.2 3.4 1.8 9.2 1.6 3.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EFO65688.1 - 0.12 12.6 0.0 0.72 10.2 0.0 2.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 EFO65688.1 - 0.18 11.5 0.0 0.38 10.4 0.0 1.5 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain VSP PF03302.13 EFO65689.1 - 1.2e-70 238.4 153.8 1.6e-32 112.9 26.1 5.6 1 1 3 5 5 5 5 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO65689.1 - 0.19 11.8 0.1 0.96 9.5 0.0 2.2 3 0 0 3 3 3 0 Podoplanin LRR_6 PF13516.6 EFO65690.1 - 0.019 15.0 0.7 25 5.3 0.0 4.4 4 0 0 4 4 4 0 Leucine Rich repeat Jnk-SapK_ap_N PF09744.9 EFO65690.1 - 0.02 15.1 7.2 0.026 14.7 5.8 1.9 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 FANCI_S2 PF14676.6 EFO65690.1 - 0.063 13.6 1.0 0.33 11.3 0.1 2.4 3 0 0 3 3 3 0 FANCI solenoid 2 Pentapeptide_4 PF13599.6 EFO65690.1 - 0.074 13.2 5.1 0.24 11.6 0.4 3.3 3 0 0 3 3 3 0 Pentapeptide repeats (9 copies) Topoisom_I_N PF02919.15 EFO65690.1 - 0.09 12.3 0.0 0.22 11.0 0.0 1.7 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment DUF4094 PF13334.6 EFO65690.1 - 0.12 12.8 0.5 0.57 10.6 0.5 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) TMF_DNA_bd PF12329.8 EFO65690.1 - 0.14 12.2 7.4 22 5.1 1.6 3.6 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Csm2_III-A PF03750.13 EFO65690.1 - 0.27 12.1 2.7 0.73 10.7 0.2 2.8 1 1 2 3 3 3 0 Csm2 Type III-A DivIC PF04977.15 EFO65690.1 - 0.5 10.2 5.4 2.4 8.0 0.6 2.7 2 0 0 2 2 2 0 Septum formation initiator GNVR PF13807.6 EFO65690.1 - 0.56 10.2 3.5 13 5.8 0.9 3.4 3 0 0 3 3 3 0 G-rich domain on putative tyrosine kinase FlaC_arch PF05377.11 EFO65690.1 - 1.1 9.7 4.6 9 6.8 0.5 3.0 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) YabA PF06156.13 EFO65690.1 - 1.9 9.2 4.5 2.3 8.9 2.9 2.0 2 0 0 2 2 1 0 Initiation control protein YabA FAM76 PF16046.5 EFO65690.1 - 3.1 7.1 9.0 0.24 10.7 2.7 2.0 2 0 0 2 2 2 0 FAM76 protein TolA_bind_tri PF16331.5 EFO65690.1 - 5.4 7.2 9.9 5 7.3 1.5 2.9 3 0 0 3 3 3 0 TolA binding protein trimerisation EF-hand_6 PF13405.6 EFO65691.1 - 1.1e-11 43.7 0.1 1.5e-05 24.6 0.1 3.0 2 1 1 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 EFO65691.1 - 3e-10 38.9 0.0 0.00037 19.8 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFO65691.1 - 1.1e-07 32.2 0.0 0.009 16.4 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 EFO65691.1 - 1.3e-06 28.7 0.1 0.00015 22.0 0.0 2.4 2 1 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 EFO65691.1 - 0.0089 15.9 0.1 4.8 7.1 0.2 3.1 2 2 1 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 EFO65691.1 - 0.014 14.9 0.3 0.044 13.3 0.2 1.9 2 0 0 2 2 2 0 EF hand EF-hand_14 PF17959.1 EFO65691.1 - 0.066 13.6 0.0 0.17 12.3 0.0 1.7 2 0 0 2 2 2 0 EF-hand domain ERCC4 PF02732.15 EFO65692.1 - 1e-05 25.8 0.0 2.3e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain dNK PF01712.19 EFO65693.1 - 9.5e-46 156.2 0.0 1.2e-45 155.9 0.0 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_28 PF13521.6 EFO65693.1 - 4.6e-05 23.7 0.0 6.6e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EFO65693.1 - 0.0003 20.5 0.1 0.00095 18.9 0.1 1.9 1 1 0 1 1 1 1 Thymidylate kinase AAA_33 PF13671.6 EFO65693.1 - 0.00054 20.1 0.0 0.00093 19.4 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EFO65693.1 - 0.0014 19.0 0.0 2.1 8.8 0.0 2.3 2 1 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EFO65693.1 - 0.0065 17.0 0.0 0.017 15.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain CoaE PF01121.20 EFO65693.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Dephospho-CoA kinase TsaE PF02367.17 EFO65693.1 - 0.14 12.2 0.0 0.26 11.3 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SKI PF01202.22 EFO65693.1 - 0.19 11.9 0.1 6.9 6.8 0.1 2.2 2 0 0 2 2 2 0 Shikimate kinase DUF5435 PF17503.2 EFO65694.1 - 0.039 13.7 0.0 0.087 12.5 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5435) Urb2 PF10441.9 EFO65695.1 - 0.82 9.6 4.6 0.88 9.5 1.0 2.9 3 0 0 3 3 3 0 Urb2/Npa2 family Pkinase PF00069.25 EFO65696.1 - 2.8e-35 122.0 0.0 3.6e-35 121.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65696.1 - 5.1e-22 78.4 0.0 6.3e-22 78.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO65696.1 - 0.00011 21.6 0.0 0.00017 21.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like DUF1059 PF06348.11 EFO65697.1 - 9 6.6 7.9 1.7 8.9 0.3 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1059) ChW PF07538.11 EFO65698.1 - 0.4 10.6 1.4 0.6 10.1 1.4 1.3 1 0 0 1 1 1 0 Clostridial hydrophobic W Fer4_9 PF13187.6 EFO65699.1 - 3.3e-06 27.1 14.2 3.9e-06 26.9 14.2 1.1 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EFO65699.1 - 1.5e-05 25.0 15.0 1.8e-05 24.7 15.0 1.1 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 EFO65699.1 - 2.2e-05 24.3 4.1 2.2e-05 24.3 4.1 2.4 2 1 0 2 2 2 1 4Fe-4S binding domain Fer4 PF00037.27 EFO65699.1 - 3e-05 23.6 3.3 3e-05 23.6 3.3 2.5 2 1 0 2 2 2 1 4Fe-4S binding domain Fer4_2 PF12797.7 EFO65699.1 - 0.00027 20.8 4.3 0.00027 20.8 4.3 2.5 2 1 0 2 2 2 1 4Fe-4S binding domain Fer4_7 PF12838.7 EFO65699.1 - 0.00033 21.2 19.4 0.0012 19.4 4.0 2.0 1 1 0 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 EFO65699.1 - 0.00062 20.1 3.7 0.00062 20.1 3.7 2.3 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_21 PF14697.6 EFO65699.1 - 0.0022 18.1 1.8 0.0022 18.1 1.8 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 EFO65699.1 - 0.0045 17.9 14.6 0.015 16.2 3.4 2.1 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_17 PF13534.6 EFO65699.1 - 0.0083 16.7 12.7 0.018 15.6 1.0 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EFO65699.1 - 0.016 15.6 2.9 0.016 15.6 2.9 2.1 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 EFO65699.1 - 0.023 15.6 5.9 0.023 15.6 5.9 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_18 PF13746.6 EFO65699.1 - 0.28 11.4 13.2 0.55 10.5 13.2 1.4 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 EFO65699.1 - 1.6 9.3 21.6 2 9.0 6.1 2.1 1 1 1 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Ank_2 PF12796.7 EFO65701.1 - 6.6e-27 93.9 7.5 8.8e-16 58.3 1.4 4.0 2 1 2 4 4 4 2 Ankyrin repeats (3 copies) Pkinase PF00069.25 EFO65701.1 - 5.4e-25 88.2 0.0 9.8e-25 87.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65701.1 - 1.5e-16 60.4 0.0 2.7e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ank PF00023.30 EFO65701.1 - 5.5e-16 58.2 0.4 0.032 14.7 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EFO65701.1 - 1.6e-14 52.5 1.5 0.028 14.9 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EFO65701.1 - 2.3e-13 50.0 2.9 0.00024 21.3 0.1 5.5 4 1 2 6 6 6 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO65701.1 - 1.2e-11 44.9 0.1 2.3e-07 31.2 0.1 4.4 4 1 0 4 4 4 1 Ankyrin repeats (many copies) Pkinase PF00069.25 EFO65702.1 - 6.1e-60 202.8 0.0 8.8e-60 202.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65702.1 - 5.3e-41 140.6 0.0 7.3e-41 140.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO65702.1 - 1.8e-07 30.7 0.0 0.0038 16.6 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EFO65702.1 - 0.001 17.9 0.0 0.002 17.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFO65702.1 - 0.029 13.7 0.0 0.054 12.8 0.0 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-C4H2 PF10146.9 EFO65704.1 - 0.027 14.8 2.4 0.033 14.5 2.4 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein Peptidase_S49 PF01343.18 EFO65704.1 - 0.055 13.4 0.2 0.075 13.0 0.2 1.3 1 0 0 1 1 1 0 Peptidase family S49 U5_2-snRNA_bdg PF10597.9 EFO65704.1 - 0.059 13.5 0.4 0.16 12.1 0.2 1.8 1 1 1 2 2 2 0 U5-snRNA binding site 2 of PrP8 DUF724 PF05266.14 EFO65704.1 - 0.1 12.4 4.2 0.16 11.7 4.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) COG5 PF10392.9 EFO65704.1 - 0.12 12.6 4.0 0.14 12.4 3.3 1.5 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Snf7 PF03357.21 EFO65704.1 - 0.16 11.6 8.9 0.21 11.2 8.9 1.1 1 0 0 1 1 1 0 Snf7 EF-hand_6 PF13405.6 EFO65705.1 - 0.0047 16.8 0.1 3.4 7.8 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EFO65705.1 - 0.0067 16.9 0.1 4.3 7.9 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair DUF3130 PF11328.8 EFO65705.1 - 0.12 12.7 1.4 44 4.4 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3130 VSP PF03302.13 EFO65706.1 - 3.3e-90 302.8 113.2 1e-51 176.1 29.9 4.0 1 1 3 4 4 4 3 Giardia variant-specific surface protein Ank_2 PF12796.7 EFO65709.1 - 6e-39 132.5 16.6 6.9e-10 39.4 0.2 6.1 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFO65709.1 - 3.6e-25 87.7 17.4 0.0046 17.2 0.2 9.0 1 1 8 9 9 9 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65709.1 - 6.4e-20 69.2 10.6 0.19 12.4 0.0 9.5 10 0 0 10 10 10 5 Ankyrin repeat Ank PF00023.30 EFO65709.1 - 3.5e-18 65.2 9.9 0.097 13.2 0.0 9.5 9 1 0 9 9 9 5 Ankyrin repeat Ank_4 PF13637.6 EFO65709.1 - 7.6e-14 51.9 9.4 0.076 13.6 0.0 6.9 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Big_9 PF17963.1 EFO65709.1 - 0.15 12.8 1.5 1.2 10.0 0.0 2.6 2 0 0 2 2 2 0 Bacterial Ig domain DUF2706 PF10913.8 EFO65709.1 - 0.66 9.9 2.1 17 5.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2706) NUDIX PF00293.28 EFO65711.1 - 4.7e-07 29.9 0.0 1.3e-06 28.5 0.0 1.7 2 0 0 2 2 2 1 NUDIX domain EF1_GNE PF00736.19 EFO65712.1 - 3.8e-26 91.1 1.0 7.8e-26 90.1 1.0 1.5 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EFO65712.1 - 0.00015 22.1 5.4 0.00015 22.1 5.4 2.6 3 0 0 3 3 3 1 Eukaryotic elongation factor 1 beta central acidic region Pkinase PF00069.25 EFO65713.1 - 1.6e-48 165.4 0.4 3.8e-48 164.2 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65713.1 - 1.4e-30 106.4 0.1 5e-30 104.6 0.0 2.0 3 0 0 3 3 3 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO65713.1 - 0.00027 20.4 0.1 0.00053 19.4 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EFO65713.1 - 0.0065 16.4 0.0 0.035 14.0 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family ADIP PF11559.8 EFO65713.1 - 0.0082 16.2 0.3 0.0082 16.2 0.3 2.7 3 0 0 3 3 3 1 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 EFO65713.1 - 0.01 16.1 14.7 0.018 15.2 1.6 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) YabA PF06156.13 EFO65713.1 - 0.016 15.8 6.8 0.21 12.2 1.3 2.6 1 1 1 2 2 2 0 Initiation control protein YabA DUF3450 PF11932.8 EFO65713.1 - 0.093 12.0 6.0 1.1 8.5 0.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF4763 PF15960.5 EFO65713.1 - 0.19 11.0 11.2 1.8 7.8 2.9 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4763) Fib_alpha PF08702.10 EFO65713.1 - 0.38 10.9 9.3 0.74 10.0 8.2 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family TSC22 PF01166.18 EFO65713.1 - 0.51 10.7 4.5 3.7 7.9 0.3 2.9 2 0 0 2 2 2 0 TSC-22/dip/bun family Syntaxin-6_N PF09177.11 EFO65713.1 - 0.83 10.3 8.3 8 7.1 1.1 2.8 2 1 1 3 3 2 0 Syntaxin 6, N-terminal Nup54 PF13874.6 EFO65713.1 - 1.4 9.0 8.5 1.8 8.7 5.6 2.1 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Cep57_CLD_2 PF14197.6 EFO65713.1 - 2 8.6 8.1 1 9.5 2.2 2.7 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 ZapB PF06005.12 EFO65713.1 - 8.3 6.9 8.7 13 6.3 1.3 2.7 2 0 0 2 2 2 0 Cell division protein ZapB GIT_CC PF16559.5 EFO65713.1 - 9.5 6.2 7.4 2.8 7.9 1.3 3.0 4 0 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor tRNA_synthFbeta PF17759.1 EFO65714.1 - 1.9e-28 99.4 0.0 3.8e-28 98.4 0.0 1.4 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain B3_4 PF03483.17 EFO65714.1 - 1.3e-20 73.8 0.0 3.3e-20 72.5 0.0 1.7 1 1 1 2 2 2 1 B3/4 domain PhetRS_B1 PF18262.1 EFO65714.1 - 7.2e-20 71.0 0.1 8e-19 67.6 0.0 2.3 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B5 PF03484.15 EFO65714.1 - 2.2e-12 47.1 0.0 1.3e-07 31.8 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetase B5 domain DUF2740 PF10872.8 EFO65714.1 - 0.11 12.4 0.7 2 8.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2740) Yuri_gagarin PF15934.5 EFO65715.1 - 0.012 15.5 4.7 0.024 14.5 4.7 1.5 1 0 0 1 1 1 0 Yuri gagarin JIP_LZII PF16471.5 EFO65715.1 - 0.19 11.9 15.4 0.27 11.4 5.1 3.3 2 1 0 3 3 3 0 JNK-interacting protein leucine zipper II HMMR_C PF15908.5 EFO65715.1 - 0.47 10.7 7.3 0.54 10.5 5.5 2.0 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor C-terminal DUF4407 PF14362.6 EFO65715.1 - 0.6 9.4 14.3 0.017 14.5 6.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 EFO65715.1 - 6 5.7 18.5 0.66 8.8 13.6 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein Peptidase_C1 PF00112.23 EFO65716.1 - 1.7e-31 110.0 0.1 2.2e-31 109.7 0.1 1.1 1 0 0 1 1 1 1 Papain family cysteine protease KASH_CCD PF14662.6 EFO65717.1 - 0.0031 17.4 12.7 0.0031 17.4 12.7 4.1 1 1 3 4 4 4 1 Coiled-coil region of CCDC155 or KASH HMMR_N PF15905.5 EFO65717.1 - 0.0051 16.3 5.9 0.0051 16.3 5.9 2.9 1 1 2 3 3 3 1 Hyaluronan mediated motility receptor N-terminal ZapB PF06005.12 EFO65717.1 - 0.0072 16.8 3.3 0.0072 16.8 3.3 5.6 2 1 2 4 4 3 2 Cell division protein ZapB BLOC1_2 PF10046.9 EFO65717.1 - 0.04 14.2 34.1 0.19 12.1 7.7 5.2 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SAS-6_N PF16531.5 EFO65717.1 - 0.09 13.4 5.7 0.043 14.4 2.2 2.3 2 0 0 2 2 2 0 Centriolar protein SAS N-terminal Spc7 PF08317.11 EFO65717.1 - 0.15 10.9 44.8 0.016 14.1 12.6 3.2 1 1 3 4 4 4 0 Spc7 kinetochore protein DivIC PF04977.15 EFO65717.1 - 0.29 10.9 32.9 0.24 11.2 2.3 6.1 4 3 1 5 5 5 0 Septum formation initiator Golgin_A5 PF09787.9 EFO65717.1 - 0.31 10.5 36.5 2.5 7.5 9.7 2.8 1 1 2 3 3 3 0 Golgin subfamily A member 5 MbeD_MobD PF04899.12 EFO65717.1 - 0.45 10.7 21.4 0.1 12.7 1.3 5.3 3 3 1 4 4 4 0 MbeD/MobD like HALZ PF02183.18 EFO65717.1 - 0.84 9.9 46.7 0.36 11.1 8.7 8.0 8 1 1 9 9 8 0 Homeobox associated leucine zipper FlaC_arch PF05377.11 EFO65717.1 - 2.6 8.5 18.4 8.4 6.9 0.3 5.2 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) GAS PF13851.6 EFO65717.1 - 2.8 7.2 42.7 0.87 8.9 16.9 3.9 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Filament PF00038.21 EFO65717.1 - 5.6 6.5 38.5 4.2 6.9 2.0 2.5 1 1 1 2 2 2 0 Intermediate filament protein DUF724 PF05266.14 EFO65717.1 - 7 6.4 26.5 0.61 9.9 2.5 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF724) DUF5383 PF17355.2 EFO65717.1 - 7.4 7.0 21.6 1.3 9.4 6.0 3.2 1 1 2 3 3 3 0 Family of unknown function (DUF5383) Tup_N PF08581.10 EFO65717.1 - 8.2 6.8 19.1 1.3 9.4 0.2 4.7 2 1 2 6 6 6 0 Tup N-terminal eIF3_subunit PF08597.10 EFO65719.1 - 3.7e-10 40.1 14.2 1.1e-09 38.6 14.2 1.6 1 1 0 1 1 1 1 Translation initiation factor eIF3 subunit RRS1 PF04939.12 EFO65720.1 - 9e-47 158.9 0.1 1.1e-46 158.7 0.1 1.0 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) Transp_Tc5_C PF04236.15 EFO65721.1 - 0.0068 16.7 0.8 0.015 15.6 0.8 1.6 1 0 0 1 1 1 1 Tc5 transposase C-terminal domain TPR_12 PF13424.6 EFO65721.1 - 0.14 12.4 0.2 1.8 8.9 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.25 EFO65722.1 - 1.7e-18 67.0 0.0 1.2e-17 64.2 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65722.1 - 3.2e-09 36.5 0.0 6.6e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase TPR_2 PF07719.17 EFO65723.1 - 3.1e-14 51.9 4.9 0.018 15.1 0.0 7.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFO65723.1 - 4.8e-12 45.2 9.0 0.00032 20.4 2.8 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFO65723.1 - 6.3e-12 44.7 5.3 0.19 12.0 0.0 6.5 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFO65723.1 - 2.5e-09 37.3 7.8 0.00069 19.9 0.0 4.6 5 1 0 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFO65723.1 - 4.8e-08 32.5 4.1 0.0037 17.2 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFO65723.1 - 8.1e-08 32.8 7.9 0.0022 18.6 1.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFO65723.1 - 5.8e-06 26.7 7.2 0.01 16.6 0.5 5.0 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFO65723.1 - 0.00028 20.6 3.7 0.98 9.4 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_4 PF07721.14 EFO65723.1 - 0.0073 16.8 2.1 11 7.0 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat RPN7 PF10602.9 EFO65723.1 - 0.015 15.0 0.2 0.45 10.2 0.1 3.0 3 0 0 3 3 3 0 26S proteasome subunit RPN7 HisKA_3 PF07730.13 EFO65723.1 - 0.45 11.1 3.4 1.5 9.4 0.3 2.8 3 0 0 3 3 2 0 Histidine kinase TPR_11 PF13414.6 EFO65723.1 - 0.72 9.6 0.0 0.72 9.6 0.0 4.6 6 1 1 7 7 7 0 TPR repeat Myb_DNA-binding PF00249.31 EFO65724.1 - 3.1e-06 27.3 0.0 5.4e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFO65724.1 - 0.00037 20.3 0.2 0.0008 19.3 0.0 1.6 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 EFO65724.1 - 0.012 15.9 0.0 0.019 15.2 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain SlyX PF04102.12 EFO65725.1 - 0.00044 20.8 12.1 0.076 13.6 0.2 3.7 4 0 0 4 4 4 2 SlyX TetR_C_11 PF16859.5 EFO65725.1 - 0.12 12.7 2.0 0.16 12.3 0.7 1.8 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain ThiS PF02597.20 EFO65725.1 - 0.12 13.0 0.3 0.59 10.8 0.1 2.3 3 0 0 3 3 3 0 ThiS family HR1 PF02185.16 EFO65725.1 - 0.16 12.1 0.2 0.16 12.1 0.2 3.3 3 1 0 3 3 3 0 Hr1 repeat Cpn60_TCP1 PF00118.24 EFO65726.1 - 6.4e-147 490.1 4.7 7.3e-147 489.9 4.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ribosomal_S13 PF00416.22 EFO65727.1 - 5.2e-38 130.3 0.8 6.1e-38 130.1 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 CLZ PF16526.5 EFO65728.1 - 0.036 14.4 0.1 24 5.4 0.0 2.9 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels LRR_6 PF13516.6 EFO65729.1 - 2.7 8.2 16.0 4.9 7.5 0.0 6.1 6 0 0 6 6 6 0 Leucine Rich repeat EzrA PF06160.12 EFO65730.1 - 0.0003 19.1 9.8 0.00047 18.5 9.8 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF1978 PF09321.10 EFO65730.1 - 0.009 15.3 8.1 0.0095 15.3 1.4 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1978) DUF4349 PF14257.6 EFO65730.1 - 0.05 13.0 2.5 0.073 12.5 2.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) TolA_bind_tri PF16331.5 EFO65730.1 - 0.053 13.6 2.0 2.9 8.1 0.1 2.7 2 1 0 2 2 2 0 TolA binding protein trimerisation VPS38 PF17649.1 EFO65730.1 - 0.061 12.2 6.2 0.078 11.8 6.2 1.1 1 0 0 1 1 1 0 Vacuolar protein sorting 38 Med30 PF11315.8 EFO65730.1 - 0.084 13.1 5.1 0.15 12.2 4.8 1.7 1 1 0 1 1 1 0 Mediator complex subunit 30 DUF1664 PF07889.12 EFO65730.1 - 0.15 12.1 9.6 0.33 11.0 1.2 2.8 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) Synaptonemal_3 PF15191.6 EFO65730.1 - 0.16 11.8 4.8 8.5 6.2 0.1 3.3 3 1 1 4 4 4 0 Synaptonemal complex central element protein 3 KxDL PF10241.9 EFO65730.1 - 0.2 12.0 9.3 5.5 7.4 0.7 3.6 3 1 0 3 3 3 0 Uncharacterized conserved protein Prefoldin_2 PF01920.20 EFO65730.1 - 0.54 10.2 12.8 2 8.4 1.9 2.9 2 1 0 2 2 2 0 Prefoldin subunit YabA PF06156.13 EFO65730.1 - 0.63 10.7 7.9 2.1 9.1 1.1 2.7 1 1 1 2 2 2 0 Initiation control protein YabA Fib_alpha PF08702.10 EFO65730.1 - 0.82 9.8 7.6 0.67 10.1 1.0 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family TRPM_tetra PF16519.5 EFO65730.1 - 0.83 9.8 4.4 1.3 9.2 1.4 2.4 2 1 1 3 3 3 0 Tetramerisation domain of TRPM Occludin_ELL PF07303.13 EFO65730.1 - 1.1 10.1 9.4 10 6.9 0.2 3.1 2 2 1 3 3 3 0 Occludin homology domain DUF4407 PF14362.6 EFO65730.1 - 1.1 8.5 10.0 1.5 8.1 9.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) FlxA PF14282.6 EFO65730.1 - 1.9 8.5 9.5 3.5 7.7 1.5 2.7 2 1 0 2 2 2 0 FlxA-like protein FapA PF03961.13 EFO65730.1 - 2 7.0 13.1 0.23 10.0 3.8 2.1 1 1 1 2 2 2 0 Flagellar Assembly Protein A ParB PF08775.10 EFO65730.1 - 4 7.9 9.8 1.2 9.7 2.7 2.5 1 1 1 2 2 2 0 ParB family DivIC PF04977.15 EFO65730.1 - 6.1 6.7 7.9 4.2 7.2 0.9 2.6 2 1 0 2 2 2 0 Septum formation initiator HTH_3 PF01381.22 EFO65731.1 - 3.4e-09 36.6 0.2 5.1e-09 36.1 0.2 1.2 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 EFO65731.1 - 1.1e-06 28.9 0.0 1.5e-06 28.5 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 EFO65731.1 - 2.5e-05 24.2 0.0 3.5e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_25 PF13413.6 EFO65731.1 - 0.0015 18.3 0.1 0.0021 17.9 0.1 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 EFO65731.1 - 0.01 16.2 0.0 0.014 15.8 0.0 1.2 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain YdaS_antitoxin PF15943.5 EFO65731.1 - 0.021 14.7 0.1 0.033 14.1 0.1 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT DUF1870 PF08965.10 EFO65731.1 - 0.11 12.6 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1870) IQ PF00612.27 EFO65732.1 - 5.1e-35 116.0 123.2 0.0018 17.9 0.1 26.2 28 0 0 28 28 28 18 IQ calmodulin-binding motif Herpes_IE1 PF07340.11 EFO65732.1 - 0.042 12.8 0.2 0.11 11.3 0.0 1.7 2 0 0 2 2 2 0 Cytomegalovirus IE1 protein Ank_2 PF12796.7 EFO65733.1 - 9.4e-47 157.5 18.0 8.2e-16 58.4 1.5 6.3 2 2 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO65733.1 - 2.2e-29 101.4 13.8 1.4e-09 38.3 0.1 8.4 6 2 4 10 10 10 7 Ankyrin repeats (many copies) Ank PF00023.30 EFO65733.1 - 4.3e-27 93.3 11.9 0.00031 21.0 0.1 9.7 9 0 0 9 9 9 8 Ankyrin repeat Ank_3 PF13606.6 EFO65733.1 - 7.2e-27 90.5 11.4 0.007 16.8 0.1 9.5 8 0 0 8 8 8 7 Ankyrin repeat Ank_5 PF13857.6 EFO65733.1 - 9.3e-27 92.8 14.7 3.5e-05 24.0 0.1 8.6 4 2 5 9 9 9 7 Ankyrin repeats (many copies) PKcGMP_CC PF16808.5 EFO65733.1 - 0.29 11.0 3.2 2.6 8.0 0.0 3.4 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase RecG_N PF17190.4 EFO65733.1 - 1.1 10.0 0.0 1.1 10.0 0.0 3.1 4 0 0 4 4 4 0 RecG N-terminal helical domain HTH_32 PF13565.6 EFO65733.1 - 1.9 9.2 4.2 1.4 9.5 1.1 2.4 2 0 0 2 2 2 0 Homeodomain-like domain VSP PF03302.13 EFO65737.1 - 8.2e-146 485.9 183.8 1.5e-130 435.6 96.7 4.4 1 1 2 4 4 4 3 Giardia variant-specific surface protein DUF724 PF05266.14 EFO65738.1 - 0.0058 16.5 2.9 0.0058 16.5 2.9 4.6 1 1 3 4 4 4 1 Protein of unknown function (DUF724) ATG16 PF08614.11 EFO65738.1 - 0.012 15.9 21.7 0.012 15.9 21.7 3.7 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) YqfQ PF14181.6 EFO65738.1 - 0.021 15.1 1.8 0.021 15.1 1.8 2.4 2 1 1 3 3 3 0 YqfQ-like protein YabA PF06156.13 EFO65738.1 - 0.027 15.1 5.9 0.027 15.1 5.9 5.8 1 1 4 5 5 5 0 Initiation control protein YabA Fez1 PF06818.15 EFO65738.1 - 1.9 8.9 46.5 0.038 14.4 18.1 2.9 1 1 2 3 3 3 0 Fez1 Filament PF00038.21 EFO65738.1 - 3.6 7.1 44.2 6.2 6.3 16.2 3.2 1 1 0 2 2 2 0 Intermediate filament protein APG6_N PF17675.1 EFO65739.1 - 0.0022 18.5 10.8 0.0022 18.5 10.8 10.6 2 1 8 11 11 11 4 Apg6 coiled-coil region Jnk-SapK_ap_N PF09744.9 EFO65739.1 - 0.0064 16.7 13.7 0.0064 16.7 13.7 9.3 3 2 6 9 9 9 3 JNK_SAPK-associated protein-1 EGF_2 PF07974.13 EFO65742.1 - 0.00051 20.3 375.5 0.0077 16.6 9.8 29.7 28 0 0 28 28 28 20 EGF-like domain EGF PF00008.27 EFO65742.1 - 0.0016 18.7 2.7 0.0016 18.7 2.7 30.3 29 2 0 29 29 29 17 EGF-like domain Plasmod_Pvs28 PF06247.11 EFO65742.1 - 0.0047 17.2 2.1 0.0047 17.2 2.1 26.4 24 4 4 28 28 28 6 Pvs28 EGF domain LMWPc PF01451.21 EFO65743.1 - 1.9e-36 125.5 0.0 2.2e-36 125.4 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Ssu72 PF04722.13 EFO65743.1 - 0.0083 15.7 0.8 0.22 11.1 0.0 2.3 3 0 0 3 3 3 2 Ssu72-like protein Ribosomal_L29e PF01779.17 EFO65744.1 - 3.8e-20 71.9 11.2 5e-20 71.5 11.2 1.2 1 0 0 1 1 1 1 Ribosomal L29e protein family HEAT PF02985.22 EFO65745.1 - 6.6e-34 113.0 33.2 0.0015 18.6 0.0 12.7 14 0 0 14 14 13 8 HEAT repeat HEAT_2 PF13646.6 EFO65745.1 - 4.4e-30 103.9 13.3 5.8e-07 29.8 0.0 7.6 5 2 3 8 8 8 6 HEAT repeats Cnd1 PF12717.7 EFO65745.1 - 5e-14 52.7 5.7 0.0092 16.0 0.1 5.7 3 1 3 6 6 6 5 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EFO65745.1 - 3e-10 40.5 2.5 0.32 11.6 0.0 7.0 4 2 3 7 7 7 3 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 EFO65745.1 - 2.9e-08 32.8 10.3 0.00069 18.3 0.8 4.9 3 2 1 4 4 4 3 Adaptin N terminal region HEAT_EZ PF13513.6 EFO65745.1 - 4.3e-07 30.3 16.8 0.5 10.9 0.0 8.8 9 2 2 11 11 11 2 HEAT-like repeat RTP1_C1 PF10363.9 EFO65745.1 - 3.6e-05 23.9 0.1 0.25 11.5 0.0 4.6 4 1 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 EFO65745.1 - 0.0039 16.8 3.9 3.3 7.2 0.0 4.7 3 1 2 6 6 6 1 CLASP N terminal Arm PF00514.23 EFO65745.1 - 0.033 14.2 0.2 14 5.9 0.0 4.0 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat SUB1_ProdP9 PF18213.1 EFO65745.1 - 0.12 12.2 0.4 4.8 7.1 0.0 3.0 3 0 0 3 3 3 0 SUB1 protease Prodomain ProdP9 Cohesin_HEAT PF12765.7 EFO65745.1 - 0.59 10.5 11.7 21 5.5 0.0 5.3 6 0 0 6 6 6 0 HEAT repeat associated with sister chromatid cohesion Roc PF08477.13 EFO65746.1 - 0.039 14.2 0.0 0.065 13.5 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFO65746.1 - 0.073 12.5 0.1 0.14 11.6 0.0 1.5 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit UVR PF02151.19 EFO65747.1 - 1.5e-09 37.3 3.8 1.5e-09 37.2 0.5 2.6 2 0 0 2 2 2 1 UvrB/uvrC motif Ribosomal_L16 PF00252.18 EFO65747.1 - 0.04 13.9 0.2 0.094 12.7 0.2 1.7 1 1 0 1 1 1 0 Ribosomal protein L16p/L10e Syntaxin-18_N PF10496.9 EFO65747.1 - 0.085 13.1 1.9 1.7 9.0 0.2 3.1 2 1 1 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus DUF2756 PF10956.8 EFO65747.1 - 2.2 8.8 8.2 0.61 10.6 3.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2756) CSD PF00313.22 EFO65748.1 - 0.022 14.6 0.1 0.39 10.6 0.1 3.0 3 0 0 3 3 3 0 'Cold-shock' DNA-binding domain Ras PF00071.22 EFO65749.1 - 8.5e-22 77.5 0.0 1e-21 77.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFO65749.1 - 6.2e-11 42.6 0.0 8.6e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EFO65749.1 - 0.00014 21.7 0.0 0.00031 20.5 0.0 1.6 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 EFO65749.1 - 0.0002 21.5 0.0 0.00048 20.3 0.0 1.6 2 1 0 2 2 1 1 AAA domain GTP_EFTU PF00009.27 EFO65749.1 - 0.0014 18.2 0.0 0.5 9.9 0.0 2.1 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EFO65749.1 - 0.0021 18.5 0.0 0.015 15.7 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EFO65749.1 - 0.0043 17.0 0.0 0.0087 16.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 EFO65749.1 - 0.0051 16.0 0.0 0.0098 15.1 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain ABC_tran PF00005.27 EFO65749.1 - 0.0055 17.2 0.0 0.012 16.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA PF00004.29 EFO65749.1 - 0.012 16.1 0.0 0.033 14.6 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 EFO65749.1 - 0.016 15.0 0.0 0.027 14.2 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Arf PF00025.21 EFO65749.1 - 0.018 14.5 0.0 0.025 14.0 0.0 1.4 1 1 0 1 1 1 0 ADP-ribosylation factor family AAA_22 PF13401.6 EFO65749.1 - 0.019 15.3 0.2 0.049 13.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain Gtr1_RagA PF04670.12 EFO65749.1 - 0.021 14.2 0.0 0.036 13.4 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 EFO65749.1 - 0.023 14.5 0.1 0.28 10.9 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_28 PF13521.6 EFO65749.1 - 0.023 14.9 0.0 0.041 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EFO65749.1 - 0.024 14.3 0.0 0.31 10.6 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Ploopntkinase3 PF18751.1 EFO65749.1 - 0.026 14.4 0.1 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Rad17 PF03215.15 EFO65749.1 - 0.03 14.3 0.2 2.4 8.1 0.0 2.7 2 1 1 3 3 3 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 EFO65749.1 - 0.032 14.1 0.0 0.73 9.7 0.0 2.3 2 1 0 2 2 2 0 RsgA GTPase dNK PF01712.19 EFO65749.1 - 0.053 13.4 0.0 0.076 12.9 0.0 1.3 1 0 0 1 1 1 0 Deoxynucleoside kinase RNA_helicase PF00910.22 EFO65749.1 - 0.057 13.8 0.0 0.42 11.0 0.0 2.2 2 0 0 2 2 2 0 RNA helicase AAA_7 PF12775.7 EFO65749.1 - 0.076 12.5 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 EFO65749.1 - 0.085 12.2 0.0 0.18 11.2 0.0 1.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EFO65749.1 - 0.091 12.5 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 EFO65749.1 - 0.1 11.8 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Septin SRP54 PF00448.22 EFO65749.1 - 0.14 11.8 0.1 1.4 8.5 0.0 2.1 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 EFO65749.1 - 0.14 12.2 0.0 0.24 11.5 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase SRPRB PF09439.10 EFO65749.1 - 0.17 11.3 0.0 2 7.8 0.0 2.1 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 EFO65749.1 - 0.18 11.8 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 EFO65749.1 - 0.19 11.4 0.5 2.1 8.0 0.0 2.3 2 1 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family ADK PF00406.22 EFO65751.1 - 7.6e-39 133.2 0.0 1.1e-38 132.7 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EFO65751.1 - 2.4e-25 89.5 0.0 7.2e-25 88.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFO65751.1 - 1.6e-05 25.4 0.0 5.4e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFO65751.1 - 0.00019 21.6 0.1 0.0059 16.8 0.0 2.5 1 1 1 2 2 2 1 AAA domain Dpy-30 PF05186.13 EFO65751.1 - 0.0013 18.4 0.0 0.002 17.8 0.0 1.4 1 0 0 1 1 1 1 Dpy-30 motif Thymidylate_kin PF02223.17 EFO65751.1 - 0.0041 16.8 0.0 0.017 14.8 0.0 2.0 2 1 1 3 3 3 1 Thymidylate kinase TPP_enzyme_C PF02775.21 EFO65752.1 - 0.084 12.7 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain ATP-synt_ab PF00006.25 EFO65753.1 - 4.8e-87 291.1 0.0 8.9e-87 290.2 0.0 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EFO65753.1 - 3.1e-36 123.9 0.0 6.3e-36 122.9 0.0 1.6 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EFO65753.1 - 7.7e-12 45.6 0.4 3.1e-11 43.6 0.4 2.1 1 1 1 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain WD40 PF00400.32 EFO65754.1 - 3e-13 50.0 10.7 0.00022 21.9 0.0 6.7 6 1 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFO65754.1 - 7.1e-11 42.3 0.0 0.0023 18.2 0.0 4.4 2 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EFO65754.1 - 0.00035 19.2 0.0 0.015 13.9 0.0 2.8 2 1 1 3 3 3 1 Cytochrome D1 heme domain PQQ_3 PF13570.6 EFO65754.1 - 0.00062 20.2 7.5 3.1 8.4 0.1 5.8 6 0 0 6 6 6 2 PQQ-like domain Ge1_WD40 PF16529.5 EFO65754.1 - 0.028 13.4 0.1 2.8 6.8 0.0 2.3 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 EFO65754.1 - 0.23 9.7 0.0 5.2 5.3 0.0 2.6 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz zf-C3HC4_2 PF13923.6 EFO65755.1 - 0.03 14.2 7.6 0.03 14.2 7.6 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.25 EFO65757.1 - 1.1e-23 83.9 0.0 1.5e-23 83.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65757.1 - 1.4e-12 47.5 0.0 1.6e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFO65757.1 - 3.1e-09 36.1 0.1 3.1e-09 36.1 0.1 1.6 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EFO65757.1 - 0.0041 17.1 0.0 0.0078 16.2 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EFO65757.1 - 0.015 14.3 0.1 0.023 13.7 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 EFO65757.1 - 0.059 12.7 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Nop14 PF04147.12 EFO65757.1 - 5.5 5.1 19.3 7.8 4.6 19.3 1.1 1 0 0 1 1 1 0 Nop14-like family Apt1 PF10351.9 EFO65757.1 - 6.3 5.5 10.2 8.7 5.1 10.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF3920 PF13058.6 EFO65758.1 - 0.033 14.4 0.1 0.85 9.8 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3920) Ank_2 PF12796.7 EFO65759.1 - 9.7e-32 109.4 1.3 1.1e-11 45.2 0.2 3.8 1 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFO65759.1 - 8.4e-18 64.5 0.8 4e-06 27.3 0.3 3.8 3 1 0 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFO65759.1 - 6.6e-16 58.2 0.4 0.00047 20.4 0.0 4.7 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFO65759.1 - 2.1e-15 55.3 2.0 0.039 14.5 0.0 6.8 6 0 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 EFO65759.1 - 4.8e-14 52.1 0.3 0.38 11.3 0.0 6.5 6 0 0 6 6 6 3 Ankyrin repeat zf-C3HC4_3 PF13920.6 EFO65759.1 - 8.8e-11 41.5 15.7 1.5e-10 40.7 15.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFO65759.1 - 0.011 15.6 14.2 0.023 14.6 14.2 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 RPN7 PF10602.9 EFO65761.1 - 4e-53 179.7 0.3 6.5e-53 179.0 0.3 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EFO65761.1 - 2.8e-07 31.0 1.1 6.5e-07 29.8 0.5 1.9 2 0 0 2 2 2 1 PCI domain Mitoc_L55 PF09776.9 EFO65761.1 - 0.11 12.3 0.2 0.19 11.5 0.2 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L55 RuvB_C PF05491.13 EFO65761.1 - 0.34 10.8 1.6 1.1 9.2 0.1 2.6 3 0 0 3 3 3 0 RuvB C-terminal winged helix domain Dynein_heavy PF03028.15 EFO65762.1 - 0.097 12.8 0.1 0.22 11.6 0.1 1.6 2 0 0 2 2 2 0 Dynein heavy chain region D6 P-loop domain EMP24_GP25L PF01105.24 EFO65764.1 - 1.3e-14 54.6 0.2 1.5e-14 54.4 0.2 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF1612 PF07756.12 EFO65764.1 - 0.029 14.6 0.3 0.043 14.1 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1612) Cadherin_C_2 PF16492.5 EFO65764.1 - 0.062 14.1 0.0 0.18 12.5 0.0 1.8 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal Metallophos PF00149.28 EFO65765.1 - 8.7e-32 111.3 0.0 1.1e-31 111.0 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFO65765.1 - 0.1 13.1 0.4 0.21 12.0 0.4 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain HECT PF00632.25 EFO65766.1 - 8.9e-79 265.1 0.9 1.2e-78 264.8 0.1 1.6 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 EFO65766.1 - 2.3e-07 30.9 0.1 1.3e-06 28.5 0.1 2.2 2 0 0 2 2 2 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A Pkinase PF00069.25 EFO65767.1 - 5.8e-72 242.2 0.0 7.4e-72 241.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFO65767.1 - 9.9e-40 136.5 0.0 1.3e-39 136.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFO65767.1 - 1.2e-05 24.8 0.0 2.7e-05 23.6 0.0 1.7 1 1 1 2 2 2 1 Kinase-like YrbL-PhoP_reg PF10707.9 EFO65767.1 - 0.0012 18.4 0.0 0.0019 17.7 0.0 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL FTA2 PF13095.6 EFO65767.1 - 0.0013 18.4 0.0 0.042 13.5 0.0 2.3 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EFO65767.1 - 0.1 11.9 0.0 1 8.7 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_C PF00433.24 EFO65767.1 - 0.94 10.2 5.5 2 9.2 4.5 2.2 2 1 0 2 2 2 0 Protein kinase C terminal domain TBP PF00352.21 EFO65768.1 - 1.5e-27 95.3 0.1 8.4e-14 51.3 0.0 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF2407_C PF13373.6 EFO65769.1 - 1.9e-06 28.1 0.0 6e-05 23.2 0.0 2.5 2 1 0 2 2 2 1 DUF2407 C-terminal domain ubiquitin PF00240.23 EFO65769.1 - 0.00039 20.1 0.0 0.00074 19.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFO65769.1 - 0.00044 20.0 0.0 0.00086 19.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 EFO65769.1 - 0.034 14.8 0.1 0.063 14.0 0.1 1.5 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD PTH2 PF01981.16 EFO65770.1 - 5.1e-35 120.3 0.4 6.1e-35 120.0 0.4 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 MgsA_C PF12002.8 EFO65771.1 - 1.5e-39 135.6 0.4 2.3e-39 135.0 0.4 1.2 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA PF00004.29 EFO65771.1 - 1.1e-09 38.8 0.0 2e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFO65771.1 - 6.6e-08 32.5 0.0 1.3e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFO65771.1 - 6e-07 29.8 0.1 4e-05 23.9 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EFO65771.1 - 6.8e-06 26.1 0.0 2e-05 24.6 0.0 1.8 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_assoc_2 PF16193.5 EFO65771.1 - 5.1e-05 23.5 0.0 0.00017 21.8 0.0 1.9 1 1 0 1 1 1 1 AAA C-terminal domain Sigma54_activat PF00158.26 EFO65771.1 - 0.00013 21.7 0.0 0.18 11.5 0.0 2.2 2 0 0 2 2 2 2 Sigma-54 interaction domain DNA_pol3_delta2 PF13177.6 EFO65771.1 - 0.00017 21.4 0.0 0.062 13.1 0.1 2.2 1 1 1 2 2 2 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 EFO65771.1 - 0.00021 21.7 0.0 0.0023 18.3 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 EFO65771.1 - 0.00022 21.3 0.0 0.00039 20.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFO65771.1 - 0.001 19.6 0.0 0.0018 18.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFO65771.1 - 0.0017 18.1 0.0 0.0046 16.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFO65771.1 - 0.0018 18.6 0.5 0.92 9.8 0.3 2.4 1 1 1 2 2 2 1 AAA domain AAA_7 PF12775.7 EFO65771.1 - 0.0041 16.6 0.0 0.007 15.9 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_3 PF07726.11 EFO65771.1 - 0.0049 16.7 0.0 0.012 15.5 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.6 EFO65771.1 - 0.006 16.7 0.1 0.014 15.5 0.0 1.6 2 0 0 2 2 1 1 Sigma-54 interaction domain AAA_24 PF13479.6 EFO65771.1 - 0.013 15.2 0.0 0.02 14.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFO65771.1 - 0.021 15.2 0.0 0.039 14.3 0.0 1.5 1 1 0 1 1 1 0 RNA helicase DUF2075 PF09848.9 EFO65771.1 - 0.026 13.8 0.6 5.6 6.1 0.0 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 EFO65771.1 - 0.044 13.5 0.0 0.094 12.4 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein ResIII PF04851.15 EFO65771.1 - 0.058 13.4 0.1 1.5 8.8 0.0 2.1 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit PhoH PF02562.16 EFO65771.1 - 0.061 12.8 0.2 2.2 7.7 0.1 2.7 2 1 1 3 3 3 0 PhoH-like protein AAA_33 PF13671.6 EFO65771.1 - 0.067 13.3 0.0 0.12 12.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EFO65771.1 - 0.096 12.0 0.3 0.36 10.2 0.0 1.9 2 0 0 2 2 2 0 KaiC AAA_11 PF13086.6 EFO65771.1 - 0.16 11.8 0.3 0.39 10.5 0.2 1.6 1 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EFO65771.1 - 0.2 11.9 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Helicase_C_2 PF13307.6 EFO65772.1 - 4.4e-36 124.6 0.0 1.4e-35 122.9 0.0 1.9 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 EFO65772.1 - 5.4e-26 91.3 0.0 1e-25 90.4 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 EFO65772.1 - 2.3e-07 31.0 0.0 9.1e-06 25.8 0.0 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFO65772.1 - 1.9e-05 24.5 0.0 0.33 10.7 0.0 3.0 3 0 0 3 3 3 2 DEAD/DEAH box helicase VSP PF03302.13 EFO65773.1 - 9.9e-107 357.2 83.9 2.1e-55 188.2 28.4 2.0 1 1 1 2 2 2 2 Giardia variant-specific surface protein Podoplanin PF05808.11 EFO65773.1 - 0.0036 17.4 1.5 0.0079 16.3 1.5 1.6 1 1 0 1 1 1 1 Podoplanin CPSF_A PF03178.15 EFO65774.1 - 1.6e-07 31.0 0.0 0.0046 16.3 0.0 2.3 2 0 0 2 2 2 2 CPSF A subunit region Ank_2 PF12796.7 EFO65775.1 - 1.8e-34 118.2 11.2 7.3e-15 55.3 0.2 3.8 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) ATG16 PF08614.11 EFO65775.1 - 1e-16 61.8 210.5 0.011 16.0 5.2 16.4 3 3 10 15 15 15 10 Autophagy protein 16 (ATG16) DUF4407 PF14362.6 EFO65775.1 - 6.1e-16 58.6 152.3 9.1e-05 21.9 11.6 11.6 1 1 9 10 10 9 7 Domain of unknown function (DUF4407) Ank_3 PF13606.6 EFO65775.1 - 1.9e-15 55.4 0.1 0.041 14.4 0.0 5.9 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EFO65775.1 - 6.3e-15 55.1 3.6 0.041 14.2 0.1 5.7 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Fez1 PF06818.15 EFO65775.1 - 5.9e-14 53.0 145.6 0.00057 20.4 7.3 12.4 1 1 10 11 11 11 7 Fez1 Spc7 PF08317.11 EFO65775.1 - 9.1e-14 51.0 182.9 0.00085 18.3 17.2 14.0 2 2 12 14 14 14 11 Spc7 kinetochore protein Ank_4 PF13637.6 EFO65775.1 - 1.1e-13 51.4 0.1 0.00012 22.5 0.1 5.0 3 1 3 6 6 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EFO65775.1 - 3e-13 49.6 1.1 0.0051 17.2 0.1 5.8 4 1 1 5 5 5 2 Ankyrin repeat HMMR_N PF15905.5 EFO65775.1 - 4.2e-10 39.6 152.4 0.014 14.9 6.5 11.3 4 3 4 10 10 10 8 Hyaluronan mediated motility receptor N-terminal AAA_13 PF13166.6 EFO65775.1 - 1.2e-09 37.5 116.1 0.029 13.0 6.3 9.3 1 1 8 9 9 9 8 AAA domain Atg14 PF10186.9 EFO65775.1 - 1.6e-09 37.3 117.4 0.00063 18.9 5.1 12.2 3 2 7 10 10 9 5 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4201 PF13870.6 EFO65775.1 - 2.1e-08 34.1 122.3 7.2e-05 22.6 3.1 13.9 9 4 5 14 14 13 7 Domain of unknown function (DUF4201) Filament PF00038.21 EFO65775.1 - 6.2e-08 32.6 158.6 0.15 11.7 29.8 12.3 3 3 2 6 6 6 3 Intermediate filament protein Fib_alpha PF08702.10 EFO65775.1 - 1.2e-07 32.0 92.6 0.0012 19.1 2.8 14.3 7 6 7 16 16 16 5 Fibrinogen alpha/beta chain family Lebercilin PF15619.6 EFO65775.1 - 6.6e-07 29.2 173.1 0.022 14.4 14.0 13.0 5 4 4 9 9 9 7 Ciliary protein causing Leber congenital amaurosis disease CALCOCO1 PF07888.11 EFO65775.1 - 2.7e-06 26.6 172.6 0.00013 20.9 39.7 8.5 1 1 6 8 8 8 2 Calcium binding and coiled-coil domain (CALCOCO1) like MscS_porin PF12795.7 EFO65775.1 - 9.8e-06 25.3 196.2 7.5e-05 22.4 21.4 12.8 2 2 5 10 10 10 4 Mechanosensitive ion channel porin domain UPF0242 PF06785.11 EFO65775.1 - 0.00025 21.2 35.4 0.0016 18.6 9.5 14.0 2 2 9 11 11 9 3 Uncharacterised protein family (UPF0242) N-terminus Baculo_PEP_C PF04513.12 EFO65775.1 - 0.00065 19.8 81.9 0.021 14.9 1.0 14.9 4 4 11 16 16 16 1 Baculovirus polyhedron envelope protein, PEP, C terminus ABC_tran_CTD PF16326.5 EFO65775.1 - 0.0012 19.0 3.1 0.0012 19.0 3.1 24.3 13 6 12 26 26 25 6 ABC transporter C-terminal domain DUF3450 PF11932.8 EFO65775.1 - 0.0019 17.6 4.3 0.0019 17.6 4.3 15.7 5 2 10 16 16 16 3 Protein of unknown function (DUF3450) Golgin_A5 PF09787.9 EFO65775.1 - 0.002 17.7 6.1 0.002 17.7 6.1 10.8 3 3 7 11 11 11 7 Golgin subfamily A member 5 Cast PF10174.9 EFO65775.1 - 0.0044 15.3 160.1 0.22 9.7 32.9 7.6 3 2 2 6 6 6 3 RIM-binding protein of the cytomatrix active zone MAD PF05557.13 EFO65775.1 - 0.0076 14.7 152.8 0.085 11.2 4.7 9.9 2 2 5 9 9 9 6 Mitotic checkpoint protein L31 PF09784.9 EFO65775.1 - 0.027 14.9 3.1 5.3 7.5 0.1 4.9 3 1 0 3 3 2 0 Mitochondrial ribosomal protein L31 DUF2730 PF10805.8 EFO65775.1 - 0.14 12.3 0.1 0.14 12.3 0.1 16.4 10 6 8 18 18 18 0 Protein of unknown function (DUF2730) KASH_CCD PF14662.6 EFO65775.1 - 0.15 11.8 167.1 0.022 14.6 19.2 13.4 2 2 9 12 12 10 0 Coiled-coil region of CCDC155 or KASH HOOK PF05622.12 EFO65775.1 - 0.28 9.3 170.2 0.044 11.9 6.9 9.5 1 1 2 6 6 6 0 HOOK protein EzrA PF06160.12 EFO65775.1 - 0.28 9.3 120.2 0.019 13.2 8.0 10.0 4 4 2 9 9 9 0 Septation ring formation regulator, EzrA DUF641 PF04859.12 EFO65775.1 - 0.58 10.5 135.3 0.33 11.3 1.1 19.5 6 4 13 20 20 19 0 Plant protein of unknown function (DUF641) TMPIT PF07851.13 EFO65775.1 - 0.62 9.3 79.6 0.15 11.2 3.1 11.6 7 5 5 13 13 13 0 TMPIT-like protein GAS PF13851.6 EFO65775.1 - 0.68 9.3 157.3 0.006 15.9 14.1 14.6 4 4 8 14 14 14 0 Growth-arrest specific micro-tubule binding DUF3584 PF12128.8 EFO65775.1 - 1.2 6.6 166.4 0.15 9.6 41.7 6.9 1 1 3 5 5 5 0 Protein of unknown function (DUF3584) Leu_zip PF15294.6 EFO65775.1 - 2.2 7.7 122.8 0.024 14.2 1.5 11.0 2 1 8 12 12 12 0 Leucine zipper LIF_OSM PF01291.17 EFO65775.1 - 2.2 8.4 4.4 44 4.2 0.1 4.3 4 0 0 4 4 2 0 LIF / OSM family NPV_P10 PF05531.12 EFO65775.1 - 7.2 7.2 104.5 10 6.7 0.0 20.9 10 7 8 19 19 17 0 Nucleopolyhedrovirus P10 protein Nup54_57_C PF18570.1 EFO65775.1 - 9.9 5.9 15.5 11 5.7 0.0 6.7 6 0 0 6 6 5 0 NUP57/Nup54 C-terminal domain Ank_2 PF12796.7 EFO65776.1 - 1.1e-27 96.4 2.4 1.3e-09 38.5 0.1 3.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFO65776.1 - 1.9e-16 58.5 0.8 0.006 17.0 0.0 6.0 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EFO65776.1 - 3.4e-16 58.9 2.9 0.035 14.5 0.0 6.2 6 0 0 6 6 5 4 Ankyrin repeat Ank_5 PF13857.6 EFO65776.1 - 8.3e-15 54.7 4.3 0.0012 19.1 0.0 5.2 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFO65776.1 - 3.3e-13 49.8 1.0 0.00026 21.5 0.0 5.2 2 1 3 5 5 5 4 Ankyrin repeats (many copies) GIT_CC PF16559.5 EFO65776.1 - 1.6e-06 27.9 5.5 0.00024 20.9 0.5 15.4 14 2 2 16 16 16 4 GIT coiled-coil Rho guanine nucleotide exchange factor Spc7 PF08317.11 EFO65776.1 - 2.2e-05 23.5 194.2 0.016 14.1 21.4 14.4 6 4 8 15 15 15 9 Spc7 kinetochore protein V_ATPase_I PF01496.19 EFO65776.1 - 0.00025 19.2 6.2 0.00025 19.2 6.2 9.5 2 1 8 11 11 9 1 V-type ATPase 116kDa subunit family ATG16 PF08614.11 EFO65776.1 - 0.0013 19.0 7.3 0.0013 19.0 7.3 16.4 4 3 9 15 15 14 6 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 EFO65776.1 - 0.0021 18.1 38.5 0.0031 17.6 22.7 15.4 7 6 4 13 13 13 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fez1 PF06818.15 EFO65776.1 - 0.0081 16.6 172.6 0.056 13.9 14.6 12.4 2 1 6 10 10 9 3 Fez1 BST2 PF16716.5 EFO65776.1 - 0.018 15.6 1.8 0.018 15.6 1.8 18.0 12 5 7 20 20 19 0 Bone marrow stromal antigen 2 KNTase_C PF07827.11 EFO65776.1 - 0.13 12.1 0.7 1.3 8.9 0.0 3.2 4 0 0 4 4 4 0 KNTase C-terminal domain MtrB PF05440.12 EFO65776.1 - 0.9 10.0 4.5 19 5.7 0.2 5.3 5 1 1 6 6 5 0 Tetrahydromethanopterin S-methyltransferase subunit B # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Diplomonada/Giardia_lamblia_P15-ASM18266v1/GCA_000182665.1_ASM18266v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Diplomonada/Giardia_lamblia_P15-ASM18266v1/GCA_000182665.1_ASM18266v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Diplomonada/Giardia_lamblia_P15-ASM18266v1/GCA_000182665.1_ASM18266v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Diplomonada/Giardia_lamblia_P15-ASM18266v1/GCA_000182665.1_ASM18266v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 09:14:43 2019 # [ok]